A compound having the following Formula: wherein R 1 is halogen; R 3 is H; R 4 is H; R 5 is OH; C 3-8 cycloalkyl; pyridinyl; phenyl substituted by one to three of NH 2, halogen, OH, CN or C 1-4 alkylpiperazinyl; pyrimidinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; pyrazinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; thiazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; benzimidazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; pyrazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; quinolinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; azaindazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; deazapurinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indanyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; or morpholinoyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; and R a and R b are the same or different, independently representing H; OH; alkyl; alkenyl; alkynyl; alkyloxy; cycloalkyl; heterocylyl; alkyleneamino; alkylene-N-(alkyl) 2; aryl unsubstituted or substituted with OH, halogen, CN, NH 2, NO 2, alkyl, alkenyl, alkynyl, alkyloxy or heteroaryl; heteroaryl unsubstituted or substituted with OH, halogen, CN, NH 2, NO 2, alkyl, alkenyl, alkynyl or alkyloxy; alkylene-heteroaryl; or alkylene-heterocylyl unsubstituted or substituted with alkyl; X is -C; Y is-N-; m is 0; and n is an integer of 1-2; or a tautomer, enantiomer, stereoisomer thereof, or a solvate or a pharmaceutically acceptable salt thereof. R 1 is halogen; R 3 is H; R 4 is H; R 5 is OH; C 3-8 cycloalkyl; pyridinyl; phenyl substituted by one to three of NH 2, halogen, OH, CN or C 1-4 alkylpiperazinyl; pyrimidinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; pyrazinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; thiazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; benzimidazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; pyrazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; quinolinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; azaindazolyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; deazapurinyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; indanyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; or morpholinoyl unsubstituted or substituted with NO 2, NH 2 or C 1-4 alkyl; and R a and R b are the same or different, independently representing H; OH; alkyl; alkenyl; alkynyl; alkyloxy; cycloalkyl; heterocylyl; alkyleneamino; alkylene-N-(alkyl) 2; aryl unsubstituted or substituted with OH, halogen, CN, NH 2, NO 2, alkyl, alkenyl, alkynyl, alkyloxy or heteroaryl; heteroaryl unsubstituted or substituted with OH, halogen, CN, NH 2, NO 2, alkyl, alkenyl, alkynyl or alkyloxy; alkylene-heteroaryl; or alkylene-heterocylyl unsubstituted or substituted with alkyl; X is -C; Y is-N-; m is 0; and n is an integer of 1-2; or a tautomer, enantiomer, stereoisomer thereof, or a solvate or a pharmaceutically acceptable salt thereof.