mhurhangee/ep-ind-claims huggingface dataset:
A recombinant molecule for use in treatment of cancer comprising increased RAS activity in cells compared to a corresponding healthy state, the recombinant molecule comprising a cargo polypeptide, a diphtheria toxin enzymatic fragment, and a diphtheria toxin translocation fragment, having a general structure: x-C-y-DTA-DTB wherein: x is a polypeptide or absent, C comprises a Ras/Rap1-specific endopeptidase (RRSP) from Vibrio vulnificus having the sequence set forth in SEQ ID No: 30, y comprises a linker comprising (G 4 S) 2 (SEQ ID No: 11), DTA consists of amino acids having the sequence set forth in SEQ ID No: 26, and DTB comprises amino acids having the sequence set forth in SEQ ID No: 3, wherein the DTA is linked to the DTB by way of a disulphide linkage. x is a polypeptide or absent, C comprises a Ras/Rap1-specific endopeptidase (RRSP) from Vibrio vulnificus having the sequence set forth in SEQ ID No: 30, y comprises a linker comprising (G 4 S) 2 (SEQ ID No: 11), DTA consists of amino acids having the sequence set forth in SEQ ID No: 26, and DTB comprises amino acids having the sequence set forth in SEQ ID No: 3, wherein the DTA is linked to the DTB by way of a disulphide linkage.
A securing device of a preferably strut-shaped sterile product mounting for securing it in a medical container, in particular a sterilization mesh basket, comprising: a supporting/receiving base which is provided for supporting/receiving the sterile product mounting and has an undercut portion as a fixed bearing acting in a first direction and designed to come into latching engagement with a corresponding undercut on the medical container, an undercut element as a floating bearing and movably retained in a direct or indirect fashion on the supporting/receiving base, said floating bearing acting in a second direction opposite the operating direction of the undercut portion and being designed to be brought into a latching engagement with a corresponding undercut on the medical container, and a spring element or a spring portion provided on the undercut element or on the supporting/receiving base, which is designed to preload the undercut element in the second direction while being directly or indirectly supported on the supporting/receiving base, characterized in that the undercut portion is U-shaped or hook-shaped and is designed to engage around an edge of a first recess provided on the base of the container in a form-fitting manner, and the undercut element is designed to engage around an edge of the first recess and/or of at least one second recess in a form-fitting manner from an opposite direction, wherein at least one of said securing portions (13, 14) is designed to be spring-elastic. a supporting/receiving base which is provided for supporting/receiving the sterile product mounting and has an undercut portion as a fixed bearing acting in a first direction and designed to come into latching engagement with a corresponding undercut on the medical container, an undercut element as a floating bearing and movably retained in a direct or indirect fashion on the supporting/receiving base, said floating bearing acting in a second direction opposite the operating direction of the undercut portion and being designed to be brought into a latching engagement with a corresponding undercut on the medical container, and a spring element or a spring portion provided on the undercut element or on the supporting/receiving base, which is designed to preload the undercut element in the second direction while being directly or indirectly supported on the supporting/receiving base, characterized in that the undercut portion is U-shaped or hook-shaped and is designed to engage around an edge of a first recess provided on the base of the container in a form-fitting manner, and the undercut element is designed to engage around an edge of the first recess and/or of at least one second recess in a form-fitting manner from an opposite direction, wherein at least one of said securing portions (13, 14) is designed to be spring-elastic.
Device for admitting air to and removing air from an oil tank, having a housing, the interior of which is connectable to the oil tank by way of a first housing opening and is in flow connection with the exterior space surrounding the housing by way of a second housing opening, a valve body being held between the first and second housing openings (32, 38) so as be axially movable in the interior, the valve body comprising a first passage which can be closed by a first closing member and can be released by being acted upon with a first differential pressure, and the valve body being movable from a closing position in which it closes in cooperation with a second closing member a second passage by being acted upon with a second differential pressure directed opposite to the first differential pressure into a releasing position releasing the second passage, characterized in that the first closing member comprises a dome-shaped valve diaphragm which has a sealing region which can be lifted off the first sealing surface by the valve diaphragm being acted upon with the first differential pressure and can be pressed against the first sealing surface by the valve diaphragm being acted upon with the second differential pressure.
A heating device for protecting a bearing of a wind power generator, wherein the heating device is configured to be applied to a main shaft of a wind power generator with a bearing sleeved on the main shaft, the heating device is configured to be arranged inside the main shaft at a position corresponding to the bearing, characterized in that the heating device comprises: a plurality of circular arc sections, a flexible heat source configured to be arranged between an inner wall of the main shaft and the plurality of circular arc sections, and a support device configured to support inner surfaces of the plurality of circular arc sections for closely fitting the flexible heat source against the inner wall of the main shaft; and wherein each of the plurality of circular arc sections have the same size and the number of the plurality of circular arc sections is an even number, each two radially opposed circular arc sections form a group, the support device comprises a plurality of groups of left-spiral support bars, right-spiral support bars and bi-directional-spiral sleeves, with the number of the groups the same as the number of groups of the circular arc sections, two ends of a bi-directional-spiral sleeve are respectively connected to an end of a corresponding left-spiral support bar and an end of a corresponding right-spiral support bar, and another end of the left-spiral support bar and another end of the right-spiral support bar are respectively supported in the middle of inner surfaces of the two circular arc sections in the same group. a plurality of circular arc sections, a flexible heat source configured to be arranged between an inner wall of the main shaft and the plurality of circular arc sections, and a support device configured to support inner surfaces of the plurality of circular arc sections for closely fitting the flexible heat source against the inner wall of the main shaft; and wherein each of the plurality of circular arc sections have the same size and the number of the plurality of circular arc sections is an even number, each two radially opposed circular arc sections form a group, the support device comprises a plurality of groups of left-spiral support bars, right-spiral support bars and bi-directional-spiral sleeves, with the number of the groups the same as the number of groups of the circular arc sections, two ends of a bi-directional-spiral sleeve are respectively connected to an end of a corresponding left-spiral support bar and an end of a corresponding right-spiral support bar, and another end of the left-spiral support bar and another end of the right-spiral support bar are respectively supported in the middle of inner surfaces of the two circular arc sections in the same group.
Use of a maltodextrin or a glucose syrup obtained, by acid or enzymatic hydrolysis, from a pea starch having an amylose content between 25% and 50%, expressed as dry weight relative to the dry weight of starch, for the encapsulation of hydrophobic organic compounds.
A bleeding device (1, 100) for bleeding air from a hydraulic system, the device (1, 100) comprising a valve member (2, 102) and a bleed connector (3, 103), the valve member (2, 102) comprising a socket (28, 128), a sealing face and a fluid passageway (21, 24) between the sealing face and the socket (28, 128), the bleed connector (3, 103) comprising a plug (34, 134) for releasable engaging receipt within the socket (28, 128) of the valve member (2, 102) and a fluid passageway which is in fluid communication with the fluid passageway (21, 24) of the valve member (2, 102) when the plug (34, 134) is received within the socket (28, 128), characterised in that the valve member (2, 102) is movable, in use, between a sealed position in which the sealing face seats against the sealing face of a bleed port and a bleeding position in which the sealing face is unseated to open fluid communication between the bleed port and the fluid passageways (21, 24, 31).
Method for the manufacture of an ammonium salt with formula I wherein X is selected from ammonia, melamine and guanidine, by reacting 9,10-dihydro-10-hydroxy-9-oxa-10-phosphaphenanthrene-10-one or -10-oxide (DOPO-OH) with the correspond amine or a salt thereof, characterized in that the reaction is carried out in a heterogeneous reaction mixture in which DOPO-OH and/or the corresponding amine is/are provided or added in the solid form.
Method of charging a coke oven with coal, said method comprising the following steps: a) charging coal into a coke oven chamber, whereby a heap of coal forms in said chamber; b) leveling said heap of coal; characterized in that said leveling step b) comprises: - introducing a blasting end of a blasting pipe into said heap of coal, the blasting pipe being in communication with a pressurized gas storage vessel configured to release gas blasts; - releasing at least one gas blast through said blasting end in said heap of coal in order to collapse said heap under the blast impact force and cause a leveling thereof; - removing the blasting pipe from said chamber. a) charging coal into a coke oven chamber, whereby a heap of coal forms in said chamber; b) leveling said heap of coal; characterized in that said leveling step b) comprises: - introducing a blasting end of a blasting pipe into said heap of coal, the blasting pipe being in communication with a pressurized gas storage vessel configured to release gas blasts; - releasing at least one gas blast through said blasting end in said heap of coal in order to collapse said heap under the blast impact force and cause a leveling thereof; - removing the blasting pipe from said chamber. - introducing a blasting end of a blasting pipe into said heap of coal, the blasting pipe being in communication with a pressurized gas storage vessel configured to release gas blasts; - releasing at least one gas blast through said blasting end in said heap of coal in order to collapse said heap under the blast impact force and cause a leveling thereof; - removing the blasting pipe from said chamber.
A network switching method, comprising: obtaining, by a terminal device, a network switching instruction, wherein the network switching instruction is used to instruct the terminal device to be handed over to a target network, and a priority of the target network is greater than a priority of a first-priority network in which the terminal device is currently located; and releasing, by the terminal device, a network link between the terminal device and a currently accessed first base station; intercepting and caching, by the terminal device, to-be-sent application-layer data of the terminal device; discarding, by the terminal device, a paging message in a packet switched, PS, domain that is sent by the first-priority network to the terminal device; and handing over, by the terminal device, to the target network, wherein before the releasing a network link between the terminal device and a currently accessed first base station, the method further comprises: obtaining, by the terminal device, an uplink data volume and a downlink data volume that correspond to the terminal device in a preset time period; and determining, by the terminal device, that the uplink data volume is less than a first threshold and the downlink data volume is less than a second threshold. obtaining, by a terminal device, a network switching instruction, wherein the network switching instruction is used to instruct the terminal device to be handed over to a target network, and a priority of the target network is greater than a priority of a first-priority network in which the terminal device is currently located; and releasing, by the terminal device, a network link between the terminal device and a currently accessed first base station; intercepting and caching, by the terminal device, to-be-sent application-layer data of the terminal device; discarding, by the terminal device, a paging message in a packet switched, PS, domain that is sent by the first-priority network to the terminal device; and handing over, by the terminal device, to the target network, wherein before the releasing a network link between the terminal device and a currently accessed first base station, the method further comprises: obtaining, by the terminal device, an uplink data volume and a downlink data volume that correspond to the terminal device in a preset time period; and determining, by the terminal device, that the uplink data volume is less than a first threshold and the downlink data volume is less than a second threshold. obtaining, by the terminal device, an uplink data volume and a downlink data volume that correspond to the terminal device in a preset time period; and determining, by the terminal device, that the uplink data volume is less than a first threshold and the downlink data volume is less than a second threshold.
A straddle type vehicle, like a motorcycle or a motor tricycle or a four-wheeled vehicle, comprising a head box which includes an inserted head pipe into which a handle steering shaft is inserted and an air cleaner box which sucks and filters the traveling wind from the front direction of the vehicle, wherein a main frame is provided as a separate body from said head box so as to support a power unit and a front wheel suspension device which axially supports a front wheel, and said air cleaner box is fixed on said main frame through a fixing member, which allows said head box to be supported on the main frame, and characterised in that said air cleaner box is disposed in front of a seat on which the rider is seated, a radiator for cooling said power unit in front of said air cleaner box, and a guide portion guiding the exhaust air from said radiator to the lower direction is formed on said air cleaner box.
A portable tester for fluid monitoring controllers, comprising: an electrical connector configured to be removably connected to a cable; a plurality of selector switches (1 - 8) electrically coupled to the electrical connector; and an electronic circuit coupled to the electrical connector and the selector switches, the electronic circuit configured to simulate, via the electrical connector, an output signal of at least one of a 2-wire fuel tanker trailer fluid overfill sensor and a 5-wire fuel tanker trailer fluid overfill sensor based on a selected state of the selector switches. an electrical connector configured to be removably connected to a cable; a plurality of selector switches (1 - 8) electrically coupled to the electrical connector; and an electronic circuit coupled to the electrical connector and the selector switches, the electronic circuit configured to simulate, via the electrical connector, an output signal of at least one of a 2-wire fuel tanker trailer fluid overfill sensor and a 5-wire fuel tanker trailer fluid overfill sensor based on a selected state of the selector switches.
An embedded Universal Integrated Circuit Card, eUICC, (120, 320) comprising processing circuitry and a storage device storing instructions that when executed by the processing circuitry causes the eUICC to perform a method comprising: establishing an electronic Subscriber Identity Module, eSIM, provisioning session with a provisioning server; receiving an eSIM package comprising: an eSIM encrypted with: i) a symmetric key prior to establishment of the eSIM provisioning session, the symmetric key encrypted with a key encryption key, KEK, and ii) a public key associated with the provisioning server; deriving, using a key agreement protocol, the KEK based at least in part on the public key associated with the provisioning server and a private key associated with the eUICC; using the KEK to decrypt the symmetric key; using the symmetric key to decrypt the eSIM; and installing the eSIM on the eUICC. establishing an electronic Subscriber Identity Module, eSIM, provisioning session with a provisioning server; receiving an eSIM package comprising: an eSIM encrypted with: i) a symmetric key prior to establishment of the eSIM provisioning session, the symmetric key encrypted with a key encryption key, KEK, and ii) a public key associated with the provisioning server; i) a symmetric key prior to establishment of the eSIM provisioning session, the symmetric key encrypted with a key encryption key, KEK, and ii) a public key associated with the provisioning server; deriving, using a key agreement protocol, the KEK based at least in part on the public key associated with the provisioning server and a private key associated with the eUICC; using the KEK to decrypt the symmetric key; using the symmetric key to decrypt the eSIM; and installing the eSIM on the eUICC.
A method for optical examination of eye tissue, comprising: generating a first sample beam; propagating the first sample beam to a biological tissue sample to a focus position at the biological tissue sample; detecting a first signal beam comprising first photons backscattered by the first sample beam from the focus position, wherein the first signal beam is detected using a Brillouin scattering detector, characterized in that the method further comprises: generating a second sample beam, wherein the first and second sample beams share an optical start point; propagating the second sample beam in a confocal manner with the first sample beam to the focus position; and detecting a second signal beam comprising second photons backscattered by the second sample beam from the focus position, wherein the second signal beam is detected using a second harmonic generation, SHG, detector. generating a first sample beam; propagating the first sample beam to a biological tissue sample to a focus position at the biological tissue sample; detecting a first signal beam comprising first photons backscattered by the first sample beam from the focus position, wherein the first signal beam is detected using a Brillouin scattering detector, generating a second sample beam, wherein the first and second sample beams share an optical start point; propagating the second sample beam in a confocal manner with the first sample beam to the focus position; and detecting a second signal beam comprising second photons backscattered by the second sample beam from the focus position, wherein the second signal beam is detected using a second harmonic generation, SHG, detector.
A cooking oven comprising a cooking chamber and a water intake that feeds water to a steam generator, that provides water steam to the inside of said cooking chamber, wherein the cooking oven also comprises a sterilizer located between the water intake and the steam generator, which sterilizes the water that reaches said steam generator, characterized in that the cooking oven also comprises an electrovalve located between the water intake and the sterilizer, and a control unit connected to the electrovalve, the sterilizer and the steam generator, wherein said sterilizer is an ultraviolet radiation emitter, a gamma radiation emitter, or a chemical disinfectant product injector.
A slim profile magnetically sensed user interface device, comprising: a slim profile housing assembly having a front face and a back face; a movable actuator assembly disposed in the housing assembly, the movable actuator assembly including: a front contact element having a front contact surface disposed on the front face; a back contact element having a back contact surface disposed on the back face; an actuator support assembly (440, 450); and a magnet; characterised in that the user interface device further comprises a multi-axis magnetic sensor positioned to sense a position or motion of the movable actuator assembly and generate a magnetic sensor signal associated with the position or motion of the magnet; and a processing element coupled to the multi-axis magnetic sensor, wherein the processing element is configured to receive the magnetic sensor signal and generate, based at least in part on the magnetic sensor signal, an output signal usable by an electronic computing system. a slim profile housing assembly having a front face and a back face; a movable actuator assembly disposed in the housing assembly, the movable actuator assembly including: a front contact element having a front contact surface disposed on the front face; a back contact element having a back contact surface disposed on the back face; an actuator support assembly (440, 450); and a magnet; characterised in that the user interface device further comprises a front contact element having a front contact surface disposed on the front face; a back contact element having a back contact surface disposed on the back face; an actuator support assembly (440, 450); and a magnet; characterised in that the user interface device further comprises a multi-axis magnetic sensor positioned to sense a position or motion of the movable actuator assembly and generate a magnetic sensor signal associated with the position or motion of the magnet; and a processing element coupled to the multi-axis magnetic sensor, wherein the processing element is configured to receive the magnetic sensor signal and generate, based at least in part on the magnetic sensor signal, an output signal usable by an electronic computing system.
Composition comprising an oxidized polyethylene wax, wherein the composition has an acid value of 11 to 15 mgKOH/g, preferably 12 to 15 mgKOH/g, even more preferred 12 to 14 mgKOH/g according to ASTM D1386 with respect to the total weight of the oxidized polyethylene wax, a weight average molecular weight from 4,000 to 12,000 g/mol, preferably 4,000 to 9,000 g/mol, even more preferred 5,000 to 8,000 g/mol determined according to gel permeation chromatography; and a density from 0.92 to 0.99 g/cm 3, preferably 0.93 to 0.97 g/cm 3, even more preferred 0.93 to 0.95 g/cm 3 according to ASTM D1505.