mhurhangee/ep-ind-claims huggingface dataset:
A wavefront aberration measuring apparatus which is adapted to measure a wavefront aberration of an optical system to be inspected (20, 21, 22), the wavefront aberration measuring apparatus comprising: a point light source which is adapted to supply a measuring light; a photodetector which has a detection surface arranged at a position optically conjugate with the point light source, the photodetector being configured to measure a light intensity of a spot light formed on the detection surface; and a wavefront change applying section which is arranged in an optical path between the point light source and the photodetector and which applies a wavefront change to the light outcome from the optical system (20, 21, 22); characterized by further comprising: a controller adopted to control the wavefront change applying section so that the light intensity of the spot light which is measured by the photodetector is maximized; and a measuring section which is adapted to measure the wavefront aberration of the optical system (20, 21, 22) based on the output of the photodetector and the wavefront change applied by the wavefront change applying section in a state that the light intensity of the spot light measured by the photodetector is maximized. a point light source which is adapted to supply a measuring light; a photodetector which has a detection surface arranged at a position optically conjugate with the point light source, the photodetector being configured to measure a light intensity of a spot light formed on the detection surface; and a wavefront change applying section which is arranged in an optical path between the point light source and the photodetector and which applies a wavefront change to the light outcome from the optical system (20, 21, 22); a controller adopted to control the wavefront change applying section so that the light intensity of the spot light which is measured by the photodetector is maximized; and a measuring section which is adapted to measure the wavefront aberration of the optical system (20, 21, 22) based on the output of the photodetector and the wavefront change applied by the wavefront change applying section in a state that the light intensity of the spot light measured by the photodetector is maximized.
A pressure sensor apparatus comprising: a sensor housing main body including a mounting surface, the mounting surface defining a first plane; a pressure detection chamber located within the sensor housing main body; and a protective wall protruding from an inner peripheral side wall the sensor housing main body into the pressure detection chamber; wherein the protective wall has a first inclined surface located in a second plane that intersects the first plane, and a second inclined surface is formed on an inner peripheral side wall of the pressure detection chamber, wherein the second inclined surface lies in a third plane that intersects both the first plane and the second plane the intersection with the second plane being at a location within the pressure detection chamber, characterized in that the location within the pressure detection chamber at which the third plane intersects the second plane is on the second inclined surface. a sensor housing main body including a mounting surface, the mounting surface defining a first plane; a pressure detection chamber located within the sensor housing main body; and a protective wall protruding from an inner peripheral side wall the sensor housing main body into the pressure detection chamber;
A transglutaminase-mediated site-specific antibody-drug conjugate comprising the formula: antibody-(T-(X-Y-Z a) b) c, wherein: T is 1) a glutamine-containing tag engineered at a specific site, 2) an endogenous glutamine, and/or 3) an endogenous glutamine made reactive by antibody engineering or an engineered transglutaminase; X is an amine donor unit; Y is a linker; and Z is an agent moiety; X-Y-Z is an amine donor agent site-specifically conjugated to a glutamine of T via gamma-carboxamide; a is an integer from 1 to 6; b is an integer from 1 to 6; c is an integer from 1 to 20; and wherein the product (drug-antibody ratio) of a, b, and c is at least 5 comprising a) amino acid substitutions at positions N297Q and K222R, wherein the amine donor agent is site-specifically conjugated to the endogenous glutamine at position 295 and the substituted glutamine at position 297; and b) one or more glutamine-containing tags, wherein the amine donor agent is site-specifically conjugated to the glutamine-containing tag(s) at a carboxyl terminus of a light chain of the antibody, wherein wherein the drug-antibody ratio is 5-7. T is 1) a glutamine-containing tag engineered at a specific site, 2) an endogenous glutamine, and/or 3) an endogenous glutamine made reactive by antibody engineering or an engineered transglutaminase; X is an amine donor unit; Y is a linker; and Z is an agent moiety; X-Y-Z is an amine donor agent site-specifically conjugated to a glutamine of T via gamma-carboxamide; a is an integer from 1 to 6; b is an integer from 1 to 6; c is an integer from 1 to 20; and wherein the product (drug-antibody ratio) of a, b, and c is at least 5 comprising a) amino acid substitutions at positions N297Q and K222R, wherein the amine donor agent is site-specifically conjugated to the endogenous glutamine at position 295 and the substituted glutamine at position 297; and b) one or more glutamine-containing tags, wherein the amine donor agent is site-specifically conjugated to the glutamine-containing tag(s) at a carboxyl terminus of a light chain of the antibody, wherein a) amino acid substitutions at positions N297Q and K222R, wherein the amine donor agent is site-specifically conjugated to the endogenous glutamine at position 295 and the substituted glutamine at position 297; and b) one or more glutamine-containing tags, wherein the amine donor agent is site-specifically conjugated to the glutamine-containing tag(s) at a carboxyl terminus of a light chain of the antibody, wherein the drug-antibody ratio is 5-7.
A guidewire device comprising: a micro-fabricated elongated outer member having a proximal end, a distal end, and a plurality of fenestrations, characterized in that said plurality of fenestrations define a plurality of resultant beams along a length of said elongated outer member, said elongated outer member having an outer surface and an interior surface forming a lumen extending from said proximal end to said distal end; an elastomeric matrix filling said plurality of fenestrations and covering both the interior and exterior surface of said elongated outer member such that the elastomeric matrix is formed around the structure defined by said plurality of beams; a distal tip with a curved shape, wherein both an inside of the curved shape and an outside of the curved shape include at least some of the plurality of fenestrations, said fenestrations on said inside of said curved shape being filled with less elastomeric matrix than said fenestrations on said outside of said curved shape, causing said distal section to hold said curved shape; and an inner member disposed within a substantial portion of said lumen, wherein said elastomeric matrix filling said fenestrations extends through said fenestrations to cover said interior surface of said elongated outer member that forms said lumen at least partially extending along an axis of said elongated outer member from said proximal end to said distal end of said elongated outer member. a micro-fabricated elongated outer member having a proximal end, a distal end, and a plurality of fenestrations, characterized in that said plurality of fenestrations define a plurality of resultant beams along a length of said elongated outer member, said elongated outer member having an outer surface and an interior surface forming a lumen extending from said proximal end to said distal end; an elastomeric matrix filling said plurality of fenestrations and covering both the interior and exterior surface of said elongated outer member such that the elastomeric matrix is formed around the structure defined by said plurality of beams; a distal tip with a curved shape, wherein both an inside of the curved shape and an outside of the curved shape include at least some of the plurality of fenestrations, said fenestrations on said inside of said curved shape being filled with less elastomeric matrix than said fenestrations on said outside of said curved shape, causing said distal section to hold said curved shape; and an inner member disposed within a substantial portion of said lumen, wherein said elastomeric matrix filling said fenestrations extends through said fenestrations to cover said interior surface of said elongated outer member that forms said lumen at least partially extending along an axis of said elongated outer member from said proximal end to said distal end of said elongated outer member.
A cleaning assembly, comprising: a fixing mechanism; a lifting shaft penetrating through the fixing mechanism and configured to slide along an axial direction of the lifting shaft relative to the fixing mechanism, and the lifting shaft comprising a first end and a second end; a moving member connected to the first end of the lifting shaft and configured to cause the lifting shaft to slide along the axial direction of the lifting shaft; a cleaning module connected to the second end of the lifting shaft; and a first drive mechanism connected to the moving member through a transmission device and configured to cause the moving member to move in a reciprocating motion, characterized in that, the cleaning assembly further comprises a shaft sleeve and a second drive mechanism, the shaft sleeve is coupled to the lifting shaft through a splined connection or a keyed connection and configured to cause the lifting shaft to rotate, and the second drive mechanism is connected to the shaft sleeve and configured to cause the shaft sleeve to rotate. a fixing mechanism; a lifting shaft penetrating through the fixing mechanism and configured to slide along an axial direction of the lifting shaft relative to the fixing mechanism, and the lifting shaft comprising a first end and a second end; a moving member connected to the first end of the lifting shaft and configured to cause the lifting shaft to slide along the axial direction of the lifting shaft; a cleaning module connected to the second end of the lifting shaft; and a first drive mechanism connected to the moving member through a transmission device and configured to cause the moving member to move in a reciprocating motion, characterized in that, the cleaning assembly further comprises a shaft sleeve and a second drive mechanism, the shaft sleeve is coupled to the lifting shaft through a splined connection or a keyed connection and configured to cause the lifting shaft to rotate, and the second drive mechanism is connected to the shaft sleeve and configured to cause the shaft sleeve to rotate.
A method of forming a carbon-carbon composite component, the method comprising: depositing an initial carbon material into a porous carbon fiber preform using chemical vapor deposition or chemical vapor infiltration to form a rigidized porous carbon fiber preform; infusing the rigidized porous carbon fiber preform with an isotropic resin; pyrolyzing the infused isotropic resin to form carbon within pores of the rigidized porous carbon fiber preform such that the carbon formed within the pores includes at least 80% isotropic carbon; and after the infusing and the pyrolyzing, densifying the rigidized porous carbon fiber preform such that the isotropic carbon within the rigidized porous carbon fiber preform is encapsulated with a graphitizable carbon to form the carbon-carbon composite component. depositing an initial carbon material into a porous carbon fiber preform using chemical vapor deposition or chemical vapor infiltration to form a rigidized porous carbon fiber preform; infusing the rigidized porous carbon fiber preform with an isotropic resin; pyrolyzing the infused isotropic resin to form carbon within pores of the rigidized porous carbon fiber preform such that the carbon formed within the pores includes at least 80% isotropic carbon; and after the infusing and the pyrolyzing, densifying the rigidized porous carbon fiber preform such that the isotropic carbon within the rigidized porous carbon fiber preform is encapsulated with a graphitizable carbon to form the carbon-carbon composite component.
A tire comprising: a tread portion provided with a first middle main groove extending continuously in a tire circumferential direction, a second middle main groove extending continuously in the tire circumferential direction, a crown longitudinal groove extending continuously in the tire circumferential direction and disposed between the first middle main groove and the second middle main groove, a plurality of first crown lateral grooves connecting between the crown longitudinal groove and the first middle main groove, and a plurality of second crown lateral grooves connecting between the crown longitudinal groove and the second middle main groove, wherein the first crown lateral grooves and the second crown lateral grooves are arranged so as to be misaligned with each other in the tire circumferential direction, and the crown longitudinal groove is provided with at least one crown tie bar formed by raising a groove bottom of the crown longitudinal groove, characterized in that a groove width of the first middle main groove and of the second middle main groove is larger than a groove width of the crown longitudinal groove, wherein the groove width of the crown longitudinal groove is in a range of from 0.5 to 2.0 mm. a tread portion provided with a first middle main groove extending continuously in a tire circumferential direction, a second middle main groove extending continuously in the tire circumferential direction, a crown longitudinal groove extending continuously in the tire circumferential direction and disposed between the first middle main groove and the second middle main groove, a plurality of first crown lateral grooves connecting between the crown longitudinal groove and the first middle main groove, and a plurality of second crown lateral grooves connecting between the crown longitudinal groove and the second middle main groove, wherein the first crown lateral grooves and the second crown lateral grooves are arranged so as to be misaligned with each other in the tire circumferential direction, and the crown longitudinal groove is provided with at least one crown tie bar formed by raising a groove bottom of the crown longitudinal groove, characterized in that a groove width of the first middle main groove and of the second middle main groove is larger than a groove width of the crown longitudinal groove, wherein the groove width of the crown longitudinal groove is in a range of from 0.5 to 2.0 mm.
Process for building a tyre for vehicle wheels, comprising: making a carcass sleeve on a building drum comprising at least one carcass ply having axially outer edges engaged with respective annular reinforcing structures, and at least one self-sealing layer applied on a radially inner surface of the carcass sleeve, wherein said self-sealing layer is made as a band circumferentially extending along said radially inner surface and having end flaps mutually joined along a junction line extending axially with respect to the radially inner surface; by means of a transfer device, removing the carcass sleeve from the building drum; applying a piece of adhesive tape along said junction line, wherein the application of said piece comprises: arranging the piece on a support; by means of a manipulator, picking up the piece from the support and transferring it to the carcass sleeve to apply it on the junction line; wherein during the application of the piece the carcass sleeve is retained by the transfer device used to remove the carcass sleeve from the building drum. making a carcass sleeve on a building drum comprising at least one carcass ply having axially outer edges engaged with respective annular reinforcing structures, and at least one self-sealing layer applied on a radially inner surface of the carcass sleeve, wherein said self-sealing layer is made as a band circumferentially extending along said radially inner surface and having end flaps mutually joined along a junction line extending axially with respect to the radially inner surface; by means of a transfer device, removing the carcass sleeve from the building drum; applying a piece of adhesive tape along said junction line, wherein the application of said piece comprises: arranging the piece on a support; by means of a manipulator, picking up the piece from the support and transferring it to the carcass sleeve to apply it on the junction line; wherein during the application of the piece the carcass sleeve is retained by the transfer device used to remove the carcass sleeve from the building drum. arranging the piece on a support; by means of a manipulator, picking up the piece from the support and transferring it to the carcass sleeve to apply it on the junction line; wherein during the application of the piece the carcass sleeve is retained by the transfer device used to remove the carcass sleeve from the building drum.
A hemadynamometer comprising: a first pulse wave sensor and a second pulse wave sensor disposed apart from each other, each of the first pulse wave sensor and the second pulse wave sensor being configured to convert a pulse wave signal corresponding to a blood pressure into an electric signal; a pressurization unit disposed between the first pulse wave sensor and the second pulse wave sensor and configured to apply a pressure to a wrist to change a diameter of a blood vessel; and a controller configured to measure the blood pressure based on first and second pulse wave signals detected respectively by the first pulse wave sensor and the second pulse wave sensor before a predetermined pressure is applied to the wrist by the pressurization unit, and third and fourth pulse wave signals detected respectively by the first pulse wave sensor and the second pulse wave sensor after the predetermined pressure is applied to the wrist by the pressurization unit, characterized in that the controller is configured to separate first to fourth forward wave signals and first to fourth backward wave signals from the first to fourth pulse wave signals, and measure the blood pressure based on at least one of a difference in pulse width or a difference in peak value between the first and third backward wave signals and a difference in pulse width or a difference in peak value between the second and fourth forward wave signals. a first pulse wave sensor and a second pulse wave sensor disposed apart from each other, each of the first pulse wave sensor and the second pulse wave sensor being configured to convert a pulse wave signal corresponding to a blood pressure into an electric signal; a pressurization unit disposed between the first pulse wave sensor and the second pulse wave sensor and configured to apply a pressure to a wrist to change a diameter of a blood vessel; and a controller configured to measure the blood pressure based on first and second pulse wave signals detected respectively by the first pulse wave sensor and the second pulse wave sensor before a predetermined pressure is applied to the wrist by the pressurization unit, and third and fourth pulse wave signals detected respectively by the first pulse wave sensor and the second pulse wave sensor after the predetermined pressure is applied to the wrist by the pressurization unit, characterized in that the controller is configured to separate first to fourth forward wave signals and first to fourth backward wave signals from the first to fourth pulse wave signals, and measure the blood pressure based on at least one of a difference in pulse width or a difference in peak value between the first and third backward wave signals and a difference in pulse width or a difference in peak value between the second and fourth forward wave signals.
Method for checking an assembly wrench with integrated angle measuring device, wherein the method is characterized by the following steps: fixing the assembly wrench in a rotatable fixing device; activating the angle measuring device integrated in the assembly wrench; rotating the fixing device by at least a defined angle; reading the rotational angle measured by the angle measuring device integrated in the assembly wrench; and comparing the rotational angle measured by the angle measuring device integrated in the assembly wrench with the defined angle by which the fixing device has been rotated. fixing the assembly wrench in a rotatable fixing device; activating the angle measuring device integrated in the assembly wrench; rotating the fixing device by at least a defined angle; reading the rotational angle measured by the angle measuring device integrated in the assembly wrench; and comparing the rotational angle measured by the angle measuring device integrated in the assembly wrench with the defined angle by which the fixing device has been rotated.
A fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a G-protein coupled receptor (GPCR), wherein said first portion comprises TM1, TM2, TM3, TM4 and TM5 regions of said GPCR; b) a stable, folded protein insertion comprising a T4 lysozyme; c) a second portion of said GPCR, wherein said second portion comprises TM6 and TM7 regions of said GPCR. a) a first portion of a G-protein coupled receptor (GPCR), wherein said first portion comprises TM1, TM2, TM3, TM4 and TM5 regions of said GPCR; b) a stable, folded protein insertion comprising a T4 lysozyme; c) a second portion of said GPCR, wherein said second portion comprises TM6 and TM7 regions of said GPCR.
Step profile for a rescue vehicle, in particular for a fire fighting vehicle, comprising an extruded profile body with a mainly rectangular cross section and a mainly flat upper step surface,said profile body comprising a first groove opening towards the upper side of the profile body in which a first band-shaped lighting device is arranged and a second groove opening towards the bottom side of the profile body in which a second band-shaped lighting device is arranged, said profile body characterized in that it comprises a cross section portion as a third groove having dove tails ridges as engaging means for fixing the step profile to fixing means of a vehicle body.
A method for operating a crossing predictor, the method comprising: detecting at a first crossing predictor the presence of a train in an approach, the first crossing predictor being located at a first crossing; receiving at the first crossing predictor a first signal indicating whether a second crossing predictor spaced apart from the first crossing predictor has detected the presence of a train; determining at the first crossing predictor whether to transmit a constant warning time signal to a device located at a second crossing based at least in part on the first signal. detecting at a first crossing predictor the presence of a train in an approach, the first crossing predictor being located at a first crossing; receiving at the first crossing predictor a first signal indicating whether a second crossing predictor spaced apart from the first crossing predictor has detected the presence of a train; determining at the first crossing predictor whether to transmit a constant warning time signal to a device located at a second crossing based at least in part on the first signal.