A method of manufacturing a grain-oriented electrical steel sheet, comprising: a heating process of heating a slab, which contains, in terms of mass%, C: 0.030% to 0.150%, Si: 2.50% to 4.00%, Mn: 0.02% to 0.30%, one or two of S and Se: 0.005% to 0.040% in a total amount, an acid-soluble Al: 0.015% to 0.040%, N: 0.0030% to 0.0150%, Bi: 0.0003% to 0.0100%, Sn: 0% to 0.50%, Cu: 0% to 0.20%, one or two of Sb and Mo: 0% to 0.30% in a total amount, and the remainder including Fe and impurities, to T1°C of 1150°C to 1300°C, retaining the slab for 5 minutes to 30 hours, lowering the temperature of the slab to T2°C of T1-50°C or lower, heating the slab at T3°C of 1280°C to 1450°C, and retaining the slab for 5 minutes to 60 minutes; a hot-rolling process of hot-rolling the slab that is heated to obtain a hot-rolled steel sheet; a cold-rolling process of performing a cold-rolling including a plurality of passes with respect to the hot-rolled steel sheet to obtain a cold-rolled steel sheet having a sheet thickness of 0.30 mm or less; an intermediate annealing process of performing an intermediate annealing with respect to the hot-rolled steel sheet at least one time before the cold-rolling process or before a final pass of the cold-rolling process after interrupting the cold-rolling; a decarburization annealing process of decarburization annealing with respect to the cold-rolled steel sheet; an annealing separating agent applying process of applying an annealing separating agent to the cold-rolled steel sheet after the decarburization annealing; a final annealing process of performing a final annealing with respect to the cold-rolled steel sheet after the annealing separating agent applying process; and a secondary film applying process of applying an insulating film onto the cold-rolled steel sheet after the final annealing, wherein in the intermediate annealing process, the intermediate annealing, in which a retention is performed at a temperature of 1000°C to 1200°C for 5 seconds to 180 seconds, is performed, in the cold-rolling process, a retention treatment, in which the hot-rolled steel sheet is retained one or more times at a temperature of 130°C to 300°C for 3 minutes to 120 minutes, is performed during the plurality of passes, in the retention treatment, a retention at a temperature T°C satisfying the following Expression is performed one time to four times, and a heating rate in the decarburization annealing process is 50 °C/second or faster, 170 + Bi × 5000 ≤ T ≤ 300 here, [Bi] in Expression represents the amount of Bi in terms of mass% in the slab. a heating process of heating a slab, which contains, in terms of mass%, C: 0.030% to 0.150%, Si: 2.50% to 4.00%, Mn: 0.02% to 0.30%, one or two of S and Se: 0.005% to 0.040% in a total amount, an acid-soluble Al: 0.015% to 0.040%, N: 0.0030% to 0.0150%, Bi: 0.0003% to 0.0100%, Sn: 0% to 0.50%, Cu: 0% to 0.20%, one or two of Sb and Mo: 0% to 0.30% in a total amount, and the remainder including Fe and impurities, to T1°C of 1150°C to 1300°C, retaining the slab for 5 minutes to 30 hours, lowering the temperature of the slab to T2°C of T1-50°C or lower, heating the slab at T3°C of 1280°C to 1450°C, and retaining the slab for 5 minutes to 60 minutes; a hot-rolling process of hot-rolling the slab that is heated to obtain a hot-rolled steel sheet; a cold-rolling process of performing a cold-rolling including a plurality of passes with respect to the hot-rolled steel sheet to obtain a cold-rolled steel sheet having a sheet thickness of 0.30 mm or less; an intermediate annealing process of performing an intermediate annealing with respect to the hot-rolled steel sheet at least one time before the cold-rolling process or before a final pass of the cold-rolling process after interrupting the cold-rolling; a decarburization annealing process of decarburization annealing with respect to the cold-rolled steel sheet; an annealing separating agent applying process of applying an annealing separating agent to the cold-rolled steel sheet after the decarburization annealing; a final annealing process of performing a final annealing with respect to the cold-rolled steel sheet after the annealing separating agent applying process; and a secondary film applying process of applying an insulating film onto the cold-rolled steel sheet after the final annealing, wherein in the intermediate annealing process, the intermediate annealing, in which a retention is performed at a temperature of 1000°C to 1200°C for 5 seconds to 180 seconds, is performed, in the cold-rolling process, a retention treatment, in which the hot-rolled steel sheet is retained one or more times at a temperature of 130°C to 300°C for 3 minutes to 120 minutes, is performed during the plurality of passes, in the retention treatment, a retention at a temperature T°C satisfying the following Expression is performed one time to four times, and a heating rate in the decarburization annealing process is 50 °C/second or faster, 170 + Bi × 5000 ≤ T ≤ 300 here, [Bi] in Expression represents the amount of Bi in terms of mass% in the slab.