mhurhangee/ep-ind-claims huggingface dataset:
A polypeptide, comprising a binding domain consisting of three peptide TNF homology domains of TNF-ligand family member proteins that specifically bind to the extracellular part of TNFR2, wherein the C-terminus of the first and second THD, respectively, which is in each case defined by the C-terminal sequence V-Y-F-G-I-I (SEQ ID NO: 3), is linked to the N-terminus of the second and third THD, respectively, which is in each case defined by the N-terminal sequence P-V-A-H-V (SEQ ID NO: 4) through a peptide X a, which is in each case independently selected and has a length of 9 to 10 amino acids, wherein the peptide X a consists of X C -X L -X N wherein X C is A-L; X L is absent or is selected from the group consisting of G, G-G, G-G-G, G-G-G-G (SEQ ID NO: 16); X N is selected from the group consisting of P-S-D-K (SEQ ID NO: 6), T-P-S-D-K (SEQ ID NO: 7), R-T-P-S-D-K (SEQ ID NO: 8), S-R-T-P-S-D-K (SEQ ID NO: 9), wherein the THD comprises a contiguous amino acid sequence consisting of amino acids 88 to 231 of full length human TNF alpha with SEQ ID NO: 5, comprising the mutations D143N and A145R of the ectodomain of human TNF alpha corresponding to D219N and A221R, respectively, relative to SEQ ID NO:5. is linked to the N-terminus of the second and third THD, respectively, which is in each case defined by the N-terminal sequence P-V-A-H-V (SEQ ID NO: 4) through a peptide X a, which is in each case independently selected and has a length of 9 to 10 amino acids, wherein the peptide X a consists of X C -X L -X N wherein X C is A-L; X L is absent or is selected from the group consisting of G, G-G, G-G-G, G-G-G-G (SEQ ID NO: 16); X N is selected from the group consisting of P-S-D-K (SEQ ID NO: 6), T-P-S-D-K (SEQ ID NO: 7), R-T-P-S-D-K (SEQ ID NO: 8), S-R-T-P-S-D-K (SEQ ID NO: 9), wherein the THD comprises a contiguous amino acid sequence consisting of amino acids 88 to 231 of full length human TNF alpha with SEQ ID NO: 5, comprising the mutations D143N and A145R of the ectodomain of human TNF alpha corresponding to D219N and A221R, respectively, relative to SEQ ID NO:5.
An assembled battery (1, 1', 1 ") comprising a plurality of air cells (10, 10'), the air cells each including: a positive electrode layer, an electrolyte layer stacked on the positive electrode layer; a negative electrode layer stacked on the electrolyte layer; and characterized by an electrically-conductive liquid-tight ventilation layer stacked on the positive electrode layer on an opposite side of the electrolyte layer, wherein a flow path through which oxygen-containing gas flows is interposed between the electrically-conductive liquid-tight ventilation layer of a first air cell and the negative electrode layer of a second air cell adjacent to the first air cell, and the first air cell is electrically connected to the negative electrode layer of the second air cell via the electrically-conductive liquid-tight ventilation layer. positive electrode layer, an electrolyte layer stacked on the positive electrode layer; a negative electrode layer stacked on the electrolyte layer; and characterized by an electrically-conductive liquid-tight ventilation layer stacked on the positive electrode layer on an opposite side of the electrolyte layer, wherein a flow path through which oxygen-containing gas flows is interposed between the electrically-conductive liquid-tight ventilation layer of a first air cell and the negative electrode layer of a second air cell adjacent to the first air cell, and the first air cell is electrically connected to the negative electrode layer of the second air cell via the electrically-conductive liquid-tight ventilation layer. wherein a flow path through which oxygen-containing gas flows is interposed between the electrically-conductive liquid-tight ventilation layer of a first air cell and the negative electrode layer of a second air cell adjacent to the first air cell, and the first air cell is electrically connected to the negative electrode layer of the second air cell via the electrically-conductive liquid-tight ventilation layer.
A print substrate transport assembly for transporting a print substrate in a printing apparatus, comprising a feed roller for transporting the print substrate, a platen for supporting said print substrate, a feed roller support for supporting said feed roller and a platen support for supporting said platen; wherein the platen comprises a print surface to support the print substrate; wherein the feed roller comprises an axle which is arranged for transporting the print substrate in a transport direction along the print surface; wherein the feed roller support extends in a first support direction (S 1), which is directed along the axle of the feed roller, the feed roller support being adapted for adjustably positioning the feed roller in a first adjusting direction (A 1), which first adjusting direction is substantially perpendicular to the print surface; wherein the platen support extends in a second support direction (S 2), the platen support being adapted for adjustably positioning said platen in a second adjusting direction (A 2), which second adjusting direction is substantially perpendicular to the print surface; wherein the print substrate transport assembly comprises an inner support (30; 40) which is at least partly enclosed by an outer support (30;40), wherein said inner support is one selected from the feed roller support and the platen support and wherein said outer support is an other selected from the feed roller support and the platen support; and wherein said outer support defines an enclosed volume, and wherein a suspension structure of the inner support, which connects the inner support to the corresponding feed roller or platen, extends outside of the enclosed volume.
A dental mirror suction device for suctioning liquids and particles from an oral cavity of a patient, with a tubular hollow basic body having an inner surface, an outer surface, a longitudinal axis (X-X), a connection port for a hose, and a suction port, wherein - the inner surface has a mirror viewable through the suction port, with a mirror surface and a back of the mirror, - the basic body is formed from a first basic body part and a second basic body part, - the two basic body parts (32, 34) are connected to each other in a gap-free manner in such a way that, together, they integrally form the basic body, so that the two basic body parts (32, 34) can only be separated from each other destructively, characterized in that - the mirror is retained in a mirror-accommodating portion of the first basic body part in an opening whose inner wall forms an upper retaining shoulder abutting against an outer wall of the mirror, wherein the upper retaining shoulder is formed by the first basic body part and surrounds the entire outer circumference of the mirror, - the first basic body part forms almost the entire basic body of the mirror suction device, and the second body part is disposed in the area of the back of the mirror, i.e. at the underside of the mirror suction device, and seals the opening, - the opening of the first basic body part tapers from an underside of the basic body in the direction towards the suction port and has a diameter, on its side facing towards the underside of the basic body, which is greater than the diameter of the mirror. - the inner surface has a mirror viewable through the suction port, with a mirror surface and a back of the mirror, - the basic body is formed from a first basic body part and a second basic body part, - the two basic body parts (32, 34) are connected to each other in a gap-free manner in such a way that, together, they integrally form the basic body, so that the two basic body parts (32, 34) can only be separated from each other destructively, - the mirror is retained in a mirror-accommodating portion of the first basic body part in an opening whose inner wall forms an upper retaining shoulder abutting against an outer wall of the mirror, wherein the upper retaining shoulder is formed by the first basic body part and surrounds the entire outer circumference of the mirror, - the first basic body part forms almost the entire basic body of the mirror suction device, and the second body part is disposed in the area of the back of the mirror, i.e. at the underside of the mirror suction device, and seals the opening, - the opening of the first basic body part tapers from an underside of the basic body in the direction towards the suction port and has a diameter, on its side facing towards the underside of the basic body, which is greater than the diameter of the mirror.
A computing system comprising: a central processing unit; and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan, the operations comprising: accessing a minimum prescribed dose to be delivered into and across a target; determining a number of beams and directions of the beams, wherein the directions are determined such that the beams do not overlap outside the target; and determining a beam energy for each of the beams; wherein: the beams comprise a beam comprising a plurality of beam segments (721, 722, 723, 724), wherein the operations further comprise: determining a maximum beam energy for the beam; and determining a beam segment energy for each of the beam segments as a percentage of the maximum beam energy; wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose; and wherein the system is configured so that the energy of each of the beam segments is individually defined and independently controlled. a central processing unit; and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan, the operations comprising: accessing a minimum prescribed dose to be delivered into and across a target; determining a number of beams and directions of the beams, wherein the directions are determined such that the beams do not overlap outside the target; and determining a beam energy for each of the beams; accessing a minimum prescribed dose to be delivered into and across a target; determining a number of beams and directions of the beams, wherein the directions are determined such that the beams do not overlap outside the target; and determining a beam energy for each of the beams; wherein: the beams comprise a beam comprising a plurality of beam segments (721, 722, 723, 724), wherein the operations further comprise: determining a maximum beam energy for the beam; and determining a beam segment energy for each of the beam segments as a percentage of the maximum beam energy; wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose; and wherein the system is configured so that the energy of each of the beam segments is individually defined and independently controlled. determining a maximum beam energy for the beam; and determining a beam segment energy for each of the beam segments as a percentage of the maximum beam energy; wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose; and wherein the system is configured so that the energy of each of the beam segments is individually defined and independently controlled.
An agent for lightening keratin fibers, in particular human hair, containing at least one encased particle and an oxidizing agent solution, preferably a hydrogen peroxide solution, the particles having a solid particle core selected from alkali metal silicates and containing a shell surrounding this core, characterized in that the shell consists of a modified cellulose having monomer units corresponding to formula in a proportion of at least 50 wt.% of its weight, where R1 to R8, independently of one another, represent hydrogen, a linear or branched C1 to C6 alkyl functional group, a linear or branched C1 to C6 hydroxyalkyl functional group containing one or more hydroxyl groups, a linear or branched C1 to C6 alkoxyalkyl functional group containing one or more C1 to C4 alkoxy groups, a linear or branched C1 to C6 acyl functional group or an optionally substituted benzoyl functional group, providing that - at least one of the functional groups R1 to R6 is not hydrogen, - R1 to R6, independently of one another, represent hydrogen, an acetyl functional group or a phthalate functional group, - at least one of the functional groups R1 to R6 represents an acetyl functional group and at least one of the functional groups R1 to R6 represents a phthalate functional group, - and n represents an integer of between and 10 and 1,000,000. - at least one of the functional groups R1 to R6 is not hydrogen, - R1 to R6, independently of one another, represent hydrogen, an acetyl functional group or a phthalate functional group, - at least one of the functional groups R1 to R6 represents an acetyl functional group and at least one of the functional groups R1 to R6 represents a phthalate functional group, - and n represents an integer of between and 10 and 1,000,000.
A method for production of botulinum toxin, the method comprising the steps of: (a) treating a culture of a botulinum toxin-producing strain with acid to precipitate a botulinum toxin; (b) adding buffer to the precipitated botulinum toxin, followed by treatment with a protease inhibitor and nuclease, thereby extracting the botulinum toxin; (c) treating the extracted botulinum toxin with acid to precipitate the botulinum toxin and dissolving the precipitate in buffer; and (d) purifying the botulinum toxin by anion exchange chromatography, wherein the acid precipitation of step (c) is performed by adding sulfuric acid or hydrochloric acid, to the extracted botulinum toxin, so that the extracted botulinum toxin reaches a pH of 2.5-4.5. (a) treating a culture of a botulinum toxin-producing strain with acid to precipitate a botulinum toxin; (b) adding buffer to the precipitated botulinum toxin, followed by treatment with a protease inhibitor and nuclease, thereby extracting the botulinum toxin; (c) treating the extracted botulinum toxin with acid to precipitate the botulinum toxin and dissolving the precipitate in buffer; and (d) purifying the botulinum toxin by anion exchange chromatography,
An aircraft control system comprising: a powerplant control system configured for controlling operation of a powerplant comprising an engine and a propeller; an engine controller configured to regulate a fuel flow to the engine in order to generate a desired engine output power; a propeller controller configured to a set blade pitch angle and/or a propeller rotational speed of the propeller, so as to convert the engine output power from the engine into thrust; a power throttle comprising a single throttle lever to regulate both: the engine output power; and the thrust produced by the propeller; an autothrottle controller operatively connected to the powerplant control system and the power throttle, and configured to modulate engine power without pilot input and to output a command to cause a setting change of the power throttle, wherein the setting change corresponds to a power lever angle of the power throttle; and a throttle quadrant controller comprising a servo-motor configured to physically move the power throttle in accordance with the command from the autothrottle controller. a powerplant control system configured for controlling operation of a powerplant comprising an engine and a propeller; an engine controller configured to regulate a fuel flow to the engine in order to generate a desired engine output power; a propeller controller configured to a set blade pitch angle and/or a propeller rotational speed of the propeller, so as to convert the engine output power from the engine into thrust; a power throttle comprising a single throttle lever to regulate both: the engine output power; and the thrust produced by the propeller; an autothrottle controller operatively connected to the powerplant control system and the power throttle, and configured to modulate engine power without pilot input and to output a command to cause a setting change of the power throttle, wherein the setting change corresponds to a power lever angle of the power throttle; and a throttle quadrant controller comprising a servo-motor configured to physically move the power throttle in accordance with the command from the autothrottle controller. a propeller controller configured to a set blade pitch angle and/or a propeller rotational speed of the propeller, so as to convert the engine output power from the engine into thrust; a power throttle comprising a single throttle lever to regulate both: the engine output power; and the thrust produced by the propeller; an autothrottle controller operatively connected to the powerplant control system and the power throttle, and configured to modulate engine power without pilot input and to output a command to cause a setting change of the power throttle, wherein the setting change corresponds to a power lever angle of the power throttle; and a throttle quadrant controller comprising a servo-motor configured to physically move the power throttle in accordance with the command from the autothrottle controller.
A turbine rotor disk, comprising: a radially inner portion (212, 312) comprising a wrought nickel alloy having a yield strength of at least 126 ksi (869 MPa) at 1,000°F (540 °C); and a radially outer portion (214, 314) bonded to the radially inner portion, said radially outer portion comprising a cast nickel alloy configured as a single crystal or with a grain size of ASTM 2 (grain diameter of 0.18 mm) or larger. a radially inner portion (212, 312) comprising a wrought nickel alloy having a yield strength of at least 126 ksi (869 MPa) at 1,000°F (540 °C); and a radially outer portion (214, 314) bonded to the radially inner portion, said radially outer portion comprising a cast nickel alloy configured as a single crystal or with a grain size of ASTM 2 (grain diameter of 0.18 mm) or larger.
A self-compensating resistance trainer for use with a driving mechanism having a driving wheel, said driving wheel rotatable with respect to said driving mechanism about a first rotational axis, said first rotational axis fixed with respect to said driving mechanism, said trainer comprising: a frame having a mounting portion adapted to releasably affix said first rotational axis of said driving mechanism with respect to said frame; a pivot arm being pivotably affixed to said frame about a pivot point; a resistance device being rotatable about said pivot point, said resistance device resisting rotation with respect to said pivot point, a driven cylinder being rotatable about a central axis affixed to said pivot arm, said central axis being spaced from said pivot point and substantially parallel to said pivot point, said driven cylinder imparting rotation to said resistance device; a biased contact point located where said driven cylinder contacts said driving wheel when said driving mechanism is affixed to said mounting portion of said frame, said driven cylinder contacting and being urged toward said driving wheel by a spring; and a normal force when said driving wheel is at rest, an applied force when said driving wheel rotates said driven cylinder, said applied force splitting into said normal force and a tangent force, said normal force increases when said applied force increases; and said normal force being sufficient to prevent slippage between said driven cylinder and said driving wheel. a frame having a mounting portion adapted to releasably affix said first rotational axis of said driving mechanism with respect to said frame; a pivot arm being pivotably affixed to said frame about a pivot point; a resistance device being rotatable about said pivot point, said resistance device resisting rotation with respect to said pivot point, a driven cylinder being rotatable about a central axis affixed to said pivot arm, said central axis being spaced from said pivot point and substantially parallel to said pivot point, said driven cylinder imparting rotation to said resistance device; a biased contact point located where said driven cylinder contacts said driving wheel when said driving mechanism is affixed to said mounting portion of said frame, said driven cylinder contacting and being urged toward said driving wheel by a spring; and a normal force when said driving wheel is at rest, an applied force when said driving wheel rotates said driven cylinder, said applied force splitting into said normal force and a tangent force, said normal force increases when said applied force increases; and said normal force being sufficient to prevent slippage between said driven cylinder and said driving wheel.
A method comprising: determining a level of a first signal received via a first channel of a wireless transmission system characterised by; obtaining a moving average of a plurality of determined levels of said first signal; subtracting said moving average from said determined level, and using the subtraction result for estimating a noise variance of a second signal received via a second channel of said wireless transmission system. determining a level of a first signal received via a first channel of a wireless transmission system characterised by; obtaining a moving average of a plurality of determined levels of said first signal; subtracting said moving average from said determined level, and using the subtraction result for estimating a noise variance of a second signal received via a second channel of said wireless transmission system.
A liquid-phase process for the production of H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 of formula, in the form of the acetic acid salt, which comprises the following steps: - coupling compound H-Phe-NH 2: with compound Boc-Lys -OH: to obtain a compound of formula, Boc-Lys -Phe-NH 2: - reacting compound with methanesulfonic acid MeSO 3 H to obtain the free amine salt MeSO 3 H.H-Lys -Phe-NH 2: - reacting the salt with the protected amino acid Boc-Dmt(Bzl)-OH to obtain the protected tripeptide (VIII): - treating the compound (VIII) with methanesulfonic acid to obtain the corresponding salt, MeSO 3.H-Dmt(Bzl)-Lys -Phe-NH 2: - coupling the acid salt with Z-D-Arg-ONa to form the protected tetrapeptide, Z-D-Arg-Dmt(Bzl)-Lys -Phe-NH 2: and - deprotecting compound by hydrogenolysis to obtain the tetrapetide H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 and further salifying it with acetic acid to form the corresponding salt. - coupling compound H-Phe-NH 2: with compound Boc-Lys -OH: to obtain a compound of formula, Boc-Lys -Phe-NH 2: - reacting compound with methanesulfonic acid MeSO 3 H to obtain the free amine salt MeSO 3 H.H-Lys -Phe-NH 2: - reacting the salt with the protected amino acid Boc-Dmt(Bzl)-OH to obtain the protected tripeptide (VIII): - treating the compound (VIII) with methanesulfonic acid to obtain the corresponding salt, MeSO 3.H-Dmt(Bzl)-Lys -Phe-NH 2: - coupling the acid salt with Z-D-Arg-ONa to form the protected tetrapeptide, Z-D-Arg-Dmt(Bzl)-Lys -Phe-NH 2: and - deprotecting compound by hydrogenolysis to obtain the tetrapetide H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 and further salifying it with acetic acid to form the corresponding salt.