An apparatus (100, 200, 1000), comprising: a housing (130, 230, 1030), a proximal end portion of the housing defining an opening configured to receive a portion of a medicament cartridge (140, 240, 1040) therein, a distal end portion of the housing (130, 230, 1030) including a base surface configured to contact a surface of a target tissue; and a microneedle (110, 210, 1010) having a distal end portion including a beveled surface and a proximal end portion, and defining a lumen, wherein the microneedle is coupled to the distal end portion of the housing (130, 230, 1030), the proximal end portion of the microneedle (110, 210, 1010) configured to be in fluid communication with the medicament cartridge (140, 240, 1040) when the portion of the medicament cartridge is disposed within the opening, the base surface circumscribing the proximal end portion of the microneedle (110, 210, 1010); characterized in that the apparatus comprises: a pressure sensor and a pressure feedback control system operably coupled to the housing (130, 230, 1030) and configured to provide an indication of a pressure applied at the housing during an injection procedure; and wherein the beveled surface defines a first segment arranged at a first angle relative to a centerline of the lumen defined by the microneedle (110, 210, 1010) and a second segment arranged at a second angle relative to the centerline of the lumen. a housing (130, 230, 1030), a proximal end portion of the housing defining an opening configured to receive a portion of a medicament cartridge (140, 240, 1040) therein, a distal end portion of the housing (130, 230, 1030) including a base surface configured to contact a surface of a target tissue; and a microneedle (110, 210, 1010) having a distal end portion including a beveled surface and a proximal end portion, and defining a lumen, wherein the microneedle is coupled to the distal end portion of the housing (130, 230, 1030), the proximal end portion of the microneedle (110, 210, 1010) configured to be in fluid communication with the medicament cartridge (140, 240, 1040) when the portion of the medicament cartridge is disposed within the opening, the base surface circumscribing the proximal end portion of the microneedle (110, 210, 1010); characterized in that the apparatus comprises: a pressure sensor and a pressure feedback control system operably coupled to the housing (130, 230, 1030) and configured to provide an indication of a pressure applied at the housing during an injection procedure; and wherein the beveled surface defines a first segment arranged at a first angle relative to a centerline of the lumen defined by the microneedle (110, 210, 1010) and a second segment arranged at a second angle relative to the centerline of the lumen. a pressure sensor and a pressure feedback control system operably coupled to the housing (130, 230, 1030) and configured to provide an indication of a pressure applied at the housing during an injection procedure; and wherein the beveled surface defines a first segment arranged at a first angle relative to a centerline of the lumen defined by the microneedle (110, 210, 1010) and a second segment arranged at a second angle relative to the centerline of the lumen.