A compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is hydrogen, hydroxy, halo, cyano, or alkoxy, which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; R 2 is a) hydrogen; or b) C 1-6 alkyl, C 3-8 cycloalkyl, or C 3-8 (cycloalkyl)(C 1-6)alkyl, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, C 1-6 alkyl, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; R 3 is hydrogen, hydroxy, or halo; or C 1-6 alkoxy, which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; ------ is a single bond or a double bond; R 4 is absent, hydrogen or C 1-6 alkyl; Y is C(=O) or COR 4a; R 4a is hydrogen or C 1-6 alkyl; provided that 1) when R 4 is hydrogen or C 1-6 alkyl, then ------ is a single bond and Y is C(=O); and 2) when R 4 is absent, then ------ is a double bond and Y is COR 4a; Z is (SO 2)R 5; R 5 is selected from the group consisting of: a) optionally substituted C 1-6 alkyl; b) optionally substituted C 1-6 alkoxy; c) optionally substituted C 6-14 aryl; d) optionally substituted 5- to 10-membered heteroaryl; e) optionally substituted C 3-8 cycloalkyl; and wherein the optionally substituted groups are optionally substituted by 1, 2, or 3 groups, independently selected from the group consisting of halo, halo(C 1-6)alkyl, hydroxy(C 1-6)alkyl, amino(C 1-6)alkyl, hydroxy, nitro, C 1-6 alkyl, C 1-6 alkoxy, halo(C 1-6)alkoxy, and amino. R 1 is hydrogen, hydroxy, halo, cyano, or alkoxy, which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; R 2 is a) hydrogen; or b) C 1-6 alkyl, C 3-8 cycloalkyl, or C 3-8 (cycloalkyl)(C 1-6)alkyl, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, C 1-6 alkyl, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; a) hydrogen; or b) C 1-6 alkyl, C 3-8 cycloalkyl, or C 3-8 (cycloalkyl)(C 1-6)alkyl, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, C 1-6 alkyl, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; R 3 is hydrogen, hydroxy, or halo; or C 1-6 alkoxy, which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo, halo(C 1-6)alkyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, carboxy, C 1-6 alkoxy, and C 1-6 alkoxycarbonyl; ------ is a single bond or a double bond; R 4 is absent, hydrogen or C 1-6 alkyl; Y is C(=O) or COR 4a; R 4a is hydrogen or C 1-6 alkyl; provided that 1) when R 4 is hydrogen or C 1-6 alkyl, then ------ is a single bond and Y is C(=O); and 2) when R 4 is absent, then ------ is a double bond and Y is COR 4a; 1) when R 4 is hydrogen or C 1-6 alkyl, then ------ is a single bond and Y is C(=O); and 2) when R 4 is absent, then ------ is a double bond and Y is COR 4a; Z is (SO 2)R 5; R 5 is selected from the group consisting of: a) optionally substituted C 1-6 alkyl; b) optionally substituted C 1-6 alkoxy; c) optionally substituted C 6-14 aryl; d) optionally substituted 5- to 10-membered heteroaryl; e) optionally substituted C 3-8 cycloalkyl; and a) optionally substituted C 1-6 alkyl; b) optionally substituted C 1-6 alkoxy; c) optionally substituted C 6-14 aryl; d) optionally substituted 5- to 10-membered heteroaryl; e) optionally substituted C 3-8 cycloalkyl;