mhurhangee/ep-ind-claims huggingface dataset:
A polypeptide comprising: (a) a first peptide portion consisting of an α-helix-forming amino acid sequence of myelin basic protein having the sequence PSQGKGRGLSLSRFSWGA [SEQ ID NO: 2], or a sequence having one conservative amino acid substitution or analog amino acid substitution, or deletion or addition of an amino acid relative to [SEQ ID NO: 2] that does not significantly affect or alter the function of the peptide; and (b) at least one second peptide portion comprising a tumour associated antigen epitope of survivin at least 8 amino acids in length, wherein the at least one second peptide portion comprises one or more of: STFKNWPFL [SEQ ID NO:7], LTLGEFLKL [SEQ ID NO:8]; and LRRKCAVPS [SEQ ID NO:9]; or a sequence having one conservative amino acid substitution or analog amino acid substitution, or deletion or addition of an amino acid relative to [SEQ ID NO: 7], [SEQ ID NO: 8] or [SEQ ID NO: 9] that does not significantly affect or alter the function of the peptide. (a) a first peptide portion consisting of an α-helix-forming amino acid sequence of myelin basic protein having the sequence PSQGKGRGLSLSRFSWGA [SEQ ID NO: 2], or a sequence having one conservative amino acid substitution or analog amino acid substitution, or deletion or addition of an amino acid relative to [SEQ ID NO: 2] that does not significantly affect or alter the function of the peptide; and (b) at least one second peptide portion comprising a tumour associated antigen epitope of survivin at least 8 amino acids in length, wherein the at least one second peptide portion comprises one or more of: STFKNWPFL [SEQ ID NO:7], LTLGEFLKL [SEQ ID NO:8]; and LRRKCAVPS [SEQ ID NO:9]; or a sequence having one conservative amino acid substitution or analog amino acid substitution, or deletion or addition of an amino acid relative to [SEQ ID NO: 7], [SEQ ID NO: 8] or [SEQ ID NO: 9] that does not significantly affect or alter the function of the peptide. STFKNWPFL [SEQ ID NO:7], LTLGEFLKL [SEQ ID NO:8]; and LRRKCAVPS [SEQ ID NO:9];
Expanding rivet with a rivet body, comprising a number of expanding arms formed on an insert section, expanding away from the insert section and ending in a free end, and with a rivet pin, longitudinally displaceably mounted in the rivet body, with which the expanding arms can be moved radially outwards in a pushed-in final assembly position of the rivet pin, wherein the rivet pin comprises a rear arresting step facing the handling end in the area of an insertion end facing away from a handling end, the free ends of the expanding arms lying opposite each other in a pre-assembly position of the rivet pin, wherein the rivet pin comprises a number of foot bridges (21, 22) projecting at the side, which extend from the rear arresting step in the direction of the handling end, characterised in that the footbridges (21, 22) project radially outwards further than the expanding arms in the pre-assembly position in an end section neighbouring the rear arresting step.
A mold which is adapted for forming a product that includes an overflow resin to be removed by a deburring device, the mold comprising a fixed mold and a movable mold forming a cavity that has a predetermined draft angle and having respective matching surfaces in wall sections at the periphery of the cavity, and a storing portion formed at a site corresponding to an entire periphery of the product, wherein the respective matching surfaces extend toward the cavity in a mold opening direction and have a predetermined inclination with respect to the mold opening direction, the inclination being provided continuously over an entire surface of the matching surfaces, wherein the storing portion being formed in a recessed shape on a surface of the movable mold, at a position between the matching surface of the movable mold and the cavity, the storing portion communicates with the cavity in a clamped condition of the mold and is configured to store the overflow resin extending along the matching surface of the fixed mold in a plate-like shape, an angle of the predetermined inclination is a same as the predetermined draft angle of the cavity. the mold comprising a fixed mold and a movable mold forming a cavity that has a predetermined draft angle and having respective matching surfaces in wall sections at the periphery of the cavity, and a storing portion formed at a site corresponding to an entire periphery of the product, wherein the respective matching surfaces extend toward the cavity in a mold opening direction and have a predetermined inclination with respect to the mold opening direction, the inclination being provided continuously over an entire surface of the matching surfaces, wherein the storing portion being formed in a recessed shape on a surface of the movable mold, at a position between the matching surface of the movable mold and the cavity, the storing portion communicates with the cavity in a clamped condition of the mold and is configured to store the overflow resin extending along the matching surface of the fixed mold in a plate-like shape, an angle of the predetermined inclination is a same as the predetermined draft angle of the cavity.
A robotic surgical instrument comprising: a shaft extending between an instrument interface at one end and an articulation at the other end, the articulation connecting an end effector element to the shaft, the articulation comprising: a first joint driveable by a first pair of driving elements (A1, A2), the first joint permitting the end effector element to rotate about a first axis transverse to a longitudinal axis of the shaft, the rotation of the end effector element about the first axis bounded by a maximum rotation angle relative to the longitudinal axis, the maximum rotation angle being the angle at the maximum travel of the first pair of driving elements about the first joint, and a second joint driveable by a second pair of driving elements (B1, B2); and a pulley arrangement around which the second pair of driving elements is constrained to move, the pulley arrangement comprising: a first set of pulleys rotatable about the first axis, and characterised by: a second set of pulleys (602, 701, 702), wherein each pulley of the second set of pulleys is rotatable about an offset axis offset from the first axis in the longitudinal direction of the shaft and in a direction transverse to the longitudinal direction of the shaft, and the second set of pulleys is located between the first set of pulleys and the instrument interface end of the shaft and relative to the first set of pulleys such that at the maximum rotation angle the second pair of driving elements is retained in contact with both the first and second sets of pulleys. a shaft extending between an instrument interface at one end and an articulation at the other end, the articulation connecting an end effector element to the shaft, the articulation comprising: a first joint driveable by a first pair of driving elements (A1, A2), the first joint permitting the end effector element to rotate about a first axis transverse to a longitudinal axis of the shaft, the rotation of the end effector element about the first axis bounded by a maximum rotation angle relative to the longitudinal axis, the maximum rotation angle being the angle at the maximum travel of the first pair of driving elements about the first joint, and a second joint driveable by a second pair of driving elements (B1, B2); and a first joint driveable by a first pair of driving elements (A1, A2), the first joint permitting the end effector element to rotate about a first axis transverse to a longitudinal axis of the shaft, the rotation of the end effector element about the first axis bounded by a maximum rotation angle relative to the longitudinal axis, the maximum rotation angle being the angle at the maximum travel of the first pair of driving elements about the first joint, and a second joint driveable by a second pair of driving elements (B1, B2); and a pulley arrangement around which the second pair of driving elements is constrained to move, the pulley arrangement comprising: a first set of pulleys rotatable about the first axis,
A non-therapeutic method for enhancing learning or memory in a subject, which comprises administering to the subject an effective amount of Compound: or a pharmaceutically acceptable salt thereof, wherein the subject is not afflicted with a neurodegenerative condition or disease.
A method for providing at least one through-substrate-via interconnect structure surrounded by at least one isolating trench-like structure, said trench-like structure having at least one airgap and said method comprising at least the steps of: - providing a substrate made of a substrate material having a first main surface, - producing simultaneously at least one through-substrate-via hole and a trench-like structure, the trench-like structure surrounding said through-substrate-via hole and being separated from the through-substrate-via hole by remaining substrate material, - thereafter, depositing a dielectric liner (2a, 2b, 2c) in order to smoothen the sidewalls of the etched through-substrate-via hole and at the same time to pinch-off the opening of the trench-like structure at the first main surface of the substrate in order to create a hollow trench-like structure with at least one airgap in said trench-like structure, and then - depositing a conductive material in said through-substrate-via hole in order to create a through-substrate-via interconnect, wherein the at least one through-substrate-via hole has a diameter between 2μm and 20μm and the trench-like structure has a trench width smaller than 1000nm. - providing a substrate made of a substrate material having a first main surface, - producing simultaneously at least one through-substrate-via hole and a trench-like structure, the trench-like structure surrounding said through-substrate-via hole and being separated from the through-substrate-via hole by remaining substrate material, - thereafter, depositing a dielectric liner (2a, 2b, 2c) in order to smoothen the sidewalls of the etched through-substrate-via hole and at the same time to pinch-off the opening of the trench-like structure at the first main surface of the substrate in order to create a hollow trench-like structure with at least one airgap in said trench-like structure, and then - depositing a conductive material in said through-substrate-via hole in order to create a through-substrate-via interconnect,
A refrigeration system, comprising: a negative pressure liquid chiller including a compressor, a condenser, an expansion device, and an evaporator fluidly connected to form a refrigeration circuit; a purge; and a refrigerant composition including an environmentally-suitable chiller refrigerant that has a 100 year direct global warming potential of less than 150, the refrigerant composition including a mixture including R-1336mzz- and R-1130-, wherein an amount of R-1336mzz- in the mixture is in a range from at or about 69% to at or about 81%, and an amount of R-1130- in the mixture is in a range from at or about 31% to at or about 19%, wherein the refrigerant composition is a low-pressure refrigerant. a negative pressure liquid chiller including a compressor, a condenser, an expansion device, and an evaporator fluidly connected to form a refrigeration circuit; a purge; and a refrigerant composition including an environmentally-suitable chiller refrigerant that has a 100 year direct global warming potential of less than 150, the refrigerant composition including a mixture including R-1336mzz- and R-1130-, wherein an amount of R-1336mzz- in the mixture is in a range from at or about 69% to at or about 81%, and an amount of R-1130- in the mixture is in a range from at or about 31% to at or about 19%, wherein the refrigerant composition is a low-pressure refrigerant.
Filter system, in particular particulate filter system, for a vacuum cleaner having - a filter element for filtering out particles of dust and/or dirt from dust-laden air, - a cleaning device for the filter element which applies at least one jet of cleaning air to an air outlet side of the filter element during a cleaning process, wherein the cleaning device is configured such that the at least one jet of cleaning air hits the filter element in an essentially punctiform manner and during a cleaning process the entire surface of the filter element is traversed by the at least one jet of cleaning air, characterised in that the cleaning device comprises a first hollow cylindrical sleeve with at least one first slot and a second hollow cylindrical sleeve which is arranged concentrically inside the first sleeve and has at least one second slot, wherein the first or second slot runs spirally over the sleeve (3; 4) and the second or first slot runs in the axial direction of the sleeve (3; 4) and at least one of the sleeves (3; 4) is rotatably mounted. - a filter element for filtering out particles of dust and/or dirt from dust-laden air, - a cleaning device for the filter element which applies at least one jet of cleaning air to an air outlet side of the filter element during a cleaning process,
Cell contacting arrangement for an energy storage module having multiple electrochemical cells, wherein each storage cell comprises at least two electrical connection terminals (3, 4), said cell contacting arrangement comprising: - a carrier plate that can be placed on the energy storage module, and - at least one cell connector that can be inserted into the carrier plate so as to connect at least two of the connection terminals (3, 4) of different storage cells, - wherein the carrier plate comprises at least one catch spring having a latching lug for fixing the cell connector in the carrier plate, characterized in that the catch spring is embodied as bow-shaped, wherein a first end of the bow is connected to the carrier plate and the latching lug is arranged on the second end of the bow. - a carrier plate that can be placed on the energy storage module, and - at least one cell connector that can be inserted into the carrier plate so as to connect at least two of the connection terminals (3, 4) of different storage cells, - wherein the carrier plate comprises at least one catch spring having a latching lug for fixing the cell connector in the carrier plate,
Layer arrangement for a gravure cylinder, which in at least a first region - has nickel in mass fraction of at least 0.80 over its entire thickness (d), - has a solid lubricant constituent at least in its radially outer region, - has a hardness of at least 400 HV 0.05 in its radially outer region, - is configured to permit the production thereon of an image by means of a laser, - has an image produced thereon by means of a laser, and - is configured to serve as the outermost layer of the gravure cylinder in gravure printing, wherein the radially outer region has poorer wettability for printing ink than does pure nickel. - has nickel in mass fraction of at least 0.80 over its entire thickness (d), - has a solid lubricant constituent at least in its radially outer region, - has a hardness of at least 400 HV 0.05 in its radially outer region, - is configured to permit the production thereon of an image by means of a laser, - has an image produced thereon by means of a laser, and - is configured to serve as the outermost layer of the gravure cylinder in gravure printing,
Adaptor for mounting a prosthesis, comprising: a male part configured to be coupled to a prosthetic pin that protrudes from a user's body; a female part that is configured to be coupled to the prosthesis and to the male part, said female part comprising an elongated cavity; and a locking ring for locking a rotation of the male part relative to the female part; characterized in that the female part further comprises an at least partially resilient ring assembly (27, 127) arranged in the cavity and being configured to expand in a radial direction when the ring assembly (27, 127) is compressed in an axial direction, wherein the male part can be arranged in or through the ring assembly (27, 127), and in that the locking ring is configured to compress the ring assembly (27, 127) in the axial direction such that the ring assembly (27, 127) expands in the radial direction to thereby lock a rotation of the male part relative to the female part; wherein the ring assembly (27, 127) comprising a plurality of first and second rings, wherein the first rings are made from essentially rigid material, wherein the second rings are made from essentially resilient material. a male part configured to be coupled to a prosthetic pin that protrudes from a user's body; a female part that is configured to be coupled to the prosthesis and to the male part, said female part comprising an elongated cavity; and a locking ring for locking a rotation of the male part relative to the female part; characterized in that the female part further comprises an at least partially resilient ring assembly (27, 127) arranged in the cavity and being configured to expand in a radial direction when the ring assembly (27, 127) is compressed in an axial direction, wherein the male part can be arranged in or through the ring assembly (27, 127), and in that the locking ring is configured to compress the ring assembly (27, 127) in the axial direction such that the ring assembly (27, 127) expands in the radial direction to thereby lock a rotation of the male part relative to the female part; wherein the ring assembly (27, 127) comprising a plurality of first and second rings, wherein the first rings are made from essentially rigid material, wherein the second rings are made from essentially resilient material.
A webbing take-up device comprising: a frame that is equipped with leg plates (14, 16); a spool that is provided in the frame and on which a webbing is taken up, and to which rotational force in a pull-out direction is applied due to the webbing being pulled; a rotating portion that is rotated by rotation of the spool; and an engaging portion that is formed on an outer peripheral portion of the rotating portion; wherein one of the leg plates (14, 16) of the frame opposes the engaging portion in a radial direction of the rotating portion, rotation of the rotating portion being suppressed by the engaging portion being engaged with the one of the leg plates (14, 16) as a result of the rotating portion being moved closer to the one of the leg plates (14, 16) in the radial direction; characterized in that an abutting portion is provided at the rotating portion, the abutting portion extends outward in the radial direction of the rotating portion, and opposes the one of the leg plates (14, 16)on one side along an axial direction of the rotating portion, movement of the rotating portion toward another side along the axial direction of the rotating portion is blocked by the abutting portion being abutted with the one of the leg plates (14, 16). a frame that is equipped with leg plates (14, 16); a spool that is provided in the frame and on which a webbing is taken up, and to which rotational force in a pull-out direction is applied due to the webbing being pulled; a rotating portion that is rotated by rotation of the spool; and an engaging portion that is formed on an outer peripheral portion of the rotating portion; wherein one of the leg plates (14, 16) of the frame opposes the engaging portion in a radial direction of the rotating portion, rotation of the rotating portion being suppressed by the engaging portion being engaged with the one of the leg plates (14, 16) as a result of the rotating portion being moved closer to the one of the leg plates (14, 16) in the radial direction; characterized in that an abutting portion is provided at the rotating portion, the abutting portion extends outward in the radial direction of the rotating portion, and opposes the one of the leg plates (14, 16)on one side along an axial direction of the rotating portion, movement of the rotating portion toward another side along the axial direction of the rotating portion is blocked by the abutting portion being abutted with the one of the leg plates (14, 16).
Method for distributing fertilizer with a centrifugal spreader, wherein, when normally passing over field tramlines in the field interior, a normal spreading pattern of a predetermined working width is used, wherein furthermore a border travel along a headland is carried out, and wherein use is made during the border travel of a border spray pattern which, in an inner border spray flank facing the field interior, differs from the normal spreading pattern in respect of the transverse distribution of the fertilizer, characterized in that a spreading flank of the normal spreading pattern is distorted trapezoidally in order to produce the inner border spreading flank.
Use of a formulation comprising: a lithium salt at a concentration of at least about 1M; at least one surfactant; and a buffer in combination with a DNA spiking solution either comprising a lithium salt at a concentration of from 10 to 15 M or an alcohol, selected from isopropanol, ethanol and / or methanol for isolating and purifying DNA. a lithium salt at a concentration of at least about 1M; at least one surfactant; and a buffer
A material comprising a transparent conductive coating and a substrate on which the coating is supported, the coating comprising a fused metal nanowire network comprising fused metal nanowires, wherein the coating has a transmittance for visible light of at least 85% and a sheet resistance of no more than 100 Ohms/square or a transmittance for visible light of at least 90% and a sheet resistance of no more than 250 Ohms/square, wherein the metal nanowires have an average diameter of no more than 250 nm.
A transmitter (110, 110a, 200, 300, 400) for radio transmission to one or more receivers (120, 120a) over a channel described at least in part by a channel matrix H, the transmitter comprising a pre-coder (210, 210a, 210b) connected to an antenna array (130, 130a, 230) via a transmit unit (220, 220a, 220b), the antenna array (130, 130a, 230) comprising a number M of antenna elements a m, m=1,2,...,M, each antenna element a m being configured to receive a respective transmit signal component x m from the pre-coder (210, 210a, 210b) via the transmit unit (220, 220a, 220b), the pre-coder being configured to receive a number K<M of data streams s k, k=1,2,...,K, and to generate the M transmit signal components, wherein the generating comprises adding M shaping components e m, m=1,2,...,M, to respective transmit signal components x m, characterized in that the shaping components e m being determined based on a null-space of the channel matrix H and on one or more properties of the transmit unit.
A rail fastening system for fastening a rail to a support comprising: a base plate configured to sit on a portion of the support and having a first recess for receiving a length of a rail; and a plurality of spring clips each arranged to clamp the base plate between the rail and the support; wherein each clip has a first arm and a second arm; the first arm of the clip is arranged to contact the rail at one location; characterised in that the second arm of the clip is configured to contact the support on a side opposite the base plate at two spaced apart locations; and each of the locations lie in different but mutually parallel planes. a base plate configured to sit on a portion of the support and having a first recess for receiving a length of a rail; and a plurality of spring clips each arranged to clamp the base plate between the rail and the support; wherein each clip has a first arm and a second arm; the first arm of the clip is arranged to contact the rail at one location; characterised in that the second arm of the clip is configured to contact the support on a side opposite the base plate at two spaced apart locations; and each of the locations lie in different but mutually parallel planes.