A genomic analysis stream management system comprising: a plurality of sequencing device interfaces configured to acquire sequence data from a plurality of sequencing devices, where the sequence data is from a plurality of patients; an analysis network; and a plurality of analysis nodes interconnected via the analysis network forming a genomic analysis engine coupled with the sequencing device interfaces, and configured to process the sequence data from the patients in parallel into genome data, the analysis nodes comprising network switches; the system further comprising a genomic stream management node configured to manage the analysis engine according to at least one stream management functionality with respect to at least one analysis stream object; wherein each of the analysis stream objects comprises an analysis data stream of the sequence data through processing to the genome data; wherein the analysis data stream is a stream of data from a sequencing device through the sequencing device interface and through the analysis engine to a point of notification having an output device, such that the analysis stream is represented as a distinct manageable object which can be controlled, manipulated, or otherwise managed; wherein the stream objects include stream attributes that describe the nature of the stream and/or include information related to the stream, and the manager node leverages the stream attributes to manage the stream with respect to analysis, routing, reporting, alerting, or other management functions; wherein the analysis engine is configured to establish processing routes among the analysis nodes according to which at least one of the sequenced data and genome data is routed; wherein the analysis stream object comprises at least one analysis route applied to the sequence data; and wherein the manager node manages the analysis engine by managing at least one manageable analysis stream object including the analysis route applied to the sequence data according to one or more management functionalities including establishing a processing route or modifying an analysis route. a plurality of sequencing device interfaces configured to acquire sequence data from a plurality of sequencing devices, where the sequence data is from a plurality of patients; an analysis network; and a plurality of analysis nodes interconnected via the analysis network forming a genomic analysis engine coupled with the sequencing device interfaces, and configured to process the sequence data from the patients in parallel into genome data, the analysis nodes comprising network switches; the system further comprising a genomic stream management node configured to manage the analysis engine according to at least one stream management functionality with respect to at least one analysis stream object; wherein each of the analysis stream objects comprises an analysis data stream of the sequence data through processing to the genome data; wherein the analysis data stream is a stream of data from a sequencing device through the sequencing device interface and through the analysis engine to a point of notification having an output device, such that the analysis stream is represented as a distinct manageable object which can be controlled, manipulated, or otherwise managed; wherein the stream objects include stream attributes that describe the nature of the stream and/or include information related to the stream, and the manager node leverages the stream attributes to manage the stream with respect to analysis, routing, reporting, alerting, or other management functions; wherein the analysis engine is configured to establish processing routes among the analysis nodes according to which at least one of the sequenced data and genome data is routed; wherein the analysis stream object comprises at least one analysis route applied to the sequence data; and wherein the manager node manages the analysis engine by managing at least one manageable analysis stream object including the analysis route applied to the sequence data according to one or more management functionalities including establishing a processing route or modifying an analysis route.