A multi-serving cartridge assembly for granulated nutritional supplements, said cartridge assembly comprising: a generally annular frame centered about a central axis, said frame including an interior hole centered about the central axis, and a plurality of serving chambers, each serving chamber having a chamber opening, a volume of granulated nutritional supplement sealed in each of said serving chambers, a plurality of marker zones spaced apart from said serving chambers, each said serving chamber being associated with one said marker zones, wherein each said marker zone is radially aligned with a respective one of said serving chambers, a marker cavity behind each said marker zone, wherein each marker cavity is in the form of a well of cup-like formation, each of said serving chambers including a fracturable element configured to be forcefully ruptured in order to extract the volume of granulated nutritional supplement therefrom, and wherein said fracturable element comprises a punctureable membrane covering the chamber openings of said serving chambers, and a spline cup affixed to the frame and centered over said interior hole, wherein an outer surface of said spline cup is configured as a graspable handle, wherein said marker zones are covered by the punctureable membrane and are configured to be physically altered concurrently with the forceful rupturing of said fracturable element to indicate that its associated serving chamber has been opened, said multi-serving cartridge being characterized in that: said spline cup includes a plurality of axially extending female splines in the spline cup that are accessible via the interior hole. a generally annular frame centered about a central axis, said frame including an interior hole centered about the central axis, and a plurality of serving chambers, each serving chamber having a chamber opening, a volume of granulated nutritional supplement sealed in each of said serving chambers, a plurality of marker zones spaced apart from said serving chambers, each said serving chamber being associated with one said marker zones, wherein each said marker zone is radially aligned with a respective one of said serving chambers, a marker cavity behind each said marker zone, wherein each marker cavity is in the form of a well of cup-like formation, each of said serving chambers including a fracturable element configured to be forcefully ruptured in order to extract the volume of granulated nutritional supplement therefrom, and wherein said fracturable element comprises a punctureable membrane covering the chamber openings of said serving chambers, and a spline cup affixed to the frame and centered over said interior hole, wherein an outer surface of said spline cup is configured as a graspable handle, wherein said marker zones are covered by the punctureable membrane and are configured to be physically altered concurrently with the forceful rupturing of said fracturable element to indicate that its associated serving chamber has been opened, said multi-serving cartridge being characterized in that: said spline cup includes a plurality of axially extending female splines in the spline cup that are accessible via the interior hole.