A bioactive botanical cosmetic composition comprising: a cell serum fraction filtrate derived from cell juice extracted from a fresh plant biomass, said cell serum fraction filtrate having antioxidant activity, cell growth stimulation activity, and/or both antioxidant and cell growth stimulation activities, wherein said fresh plant biomass is from a plant source selected from the group consisting of lotus ( Nelumbo nucifera) and red clover ( Trifolium pratense); and a stabilizing agent, wherein said cell growth stimulation activity is due to stimulation of proliferation of at least one type of cell, wherein said cell serum fraction filtrate is derived from the cell juice according to the following steps: providing the plant cell juice, said plant cell juice having been extracted from the fresh plant biomass; treating the plant cell juice under conditions effective to separate the plant cell juice into a membrane fraction and a cell juice supernatant; processing the cell juice supernatant under conditions effective to separate the cell juice supernatant into a cytoplasmic fraction and a cell serum fraction; and refining the cell serum fraction under conditions effective to yield the cell serum fraction filtrate, wherein said refining comprises subjecting the cell serum fraction to a temperature treatment step to yield a coagulated cell serum fraction, and clarifying the coagulated cell serum fraction to yield the cell serum fraction filtrate. a cell serum fraction filtrate derived from cell juice extracted from a fresh plant biomass, said cell serum fraction filtrate having antioxidant activity, cell growth stimulation activity, and/or both antioxidant and cell growth stimulation activities, wherein said fresh plant biomass is from a plant source selected from the group consisting of lotus ( Nelumbo nucifera) and red clover ( Trifolium pratense); and a stabilizing agent, wherein said cell growth stimulation activity is due to stimulation of proliferation of at least one type of cell, wherein said cell serum fraction filtrate is derived from the cell juice according to the following steps: providing the plant cell juice, said plant cell juice having been extracted from the fresh plant biomass; treating the plant cell juice under conditions effective to separate the plant cell juice into a membrane fraction and a cell juice supernatant; processing the cell juice supernatant under conditions effective to separate the cell juice supernatant into a cytoplasmic fraction and a cell serum fraction; and refining the cell serum fraction under conditions effective to yield the cell serum fraction filtrate, wherein said refining comprises subjecting the cell serum fraction to a temperature treatment step to yield a coagulated cell serum fraction, and clarifying the coagulated cell serum fraction to yield the cell serum fraction filtrate. providing the plant cell juice, said plant cell juice having been extracted from the fresh plant biomass; treating the plant cell juice under conditions effective to separate the plant cell juice into a membrane fraction and a cell juice supernatant; processing the cell juice supernatant under conditions effective to separate the cell juice supernatant into a cytoplasmic fraction and a cell serum fraction; and refining the cell serum fraction under conditions effective to yield the cell serum fraction filtrate, wherein said refining comprises subjecting the cell serum fraction to a temperature treatment step to yield a coagulated cell serum fraction, and clarifying the coagulated cell serum fraction to yield the cell serum fraction filtrate.