mhurhangee/ep-ind-claims huggingface dataset:
A skin treatment device for generating a multiphoton ionization process in a target position in skin tissue, the skin treatment device comprising: a laser source configured and constructed for generating a treatment laser beam, an optical system (109, 112) configured and constructed such that the treatment laser beam is focusable into a focal spot in the target position in the skin tissue, a plasma unit configured and constructed for generating a plasma such that, in use, at least a portion of the plasma penetrates the skin tissue and generates at least one free electron in the target position in the skin tissue, and a control unit configured and constructed for controlling the laser source and the plasma unit, characterized in that the laser source and the optical system (109, 112) are configured and constructed such that, in use, the power density (W/cm 2) of the treatment laser beam in the focal spot in the skin tissue is below a first power density threshold (I th1) for the skin tissue, above which a free electron is generated in the skin tissue by absorption of photons present in the treatment laser beam, and the power density (W/cm 2) of the treatment laser beam in the focal spot is above a second power density threshold (I th2) for the skin tissue, above which an avalanche ionization process is generated in the skin tissue by Inverse Bremsstrahlung absorption by a free electron of photons present in the treatment laser beam. a laser source configured and constructed for generating a treatment laser beam, an optical system (109, 112) configured and constructed such that the treatment laser beam is focusable into a focal spot in the target position in the skin tissue, a plasma unit configured and constructed for generating a plasma such that, in use, at least a portion of the plasma penetrates the skin tissue and generates at least one free electron in the target position in the skin tissue, and a control unit configured and constructed for controlling the laser source and the plasma unit, characterized in that the laser source and the optical system (109, 112) are configured and constructed such that, in use, the power density (W/cm 2) of the treatment laser beam in the focal spot in the skin tissue is below a first power density threshold (I th1) for the skin tissue, above which a free electron is generated in the skin tissue by absorption of photons present in the treatment laser beam, and the power density (W/cm 2) of the treatment laser beam in the focal spot is above a second power density threshold (I th2) for the skin tissue, above which an avalanche ionization process is generated in the skin tissue by Inverse Bremsstrahlung absorption by a free electron of photons present in the treatment laser beam.
Pump arrangement for delivering fuel, having a high-pressure pump for providing highly pressurized fuel and having a low-pressure pump for supplying fuel to the high-pressure pump, wherein the low-pressure pump is configured to withdraw fuel from a tank and to feed the fuel at a supply pressure to the high-pressure pump, and wherein the high-pressure pump has a pump chamber with a low-pressure valve on a low-pressure side and with a high-pressure valve on the high-pressure side, wherein the low-pressure valve has an electrically activatable magnetic valve drive and is open when electrically deenergized, closed when electrically energized and closed when electrically deenergized if a pressure difference between the pump chamber and the low-pressure side is higher than a threshold value, wherein the low-pressure valve has a state sensor by means of which an opening state of the low-pressure valve can be monitored, wherein the state sensor and the low-pressure pump are connected to one another by means of a pump control unit, and the pump control unit is configured to adapt the supply pressure in a manner dependent on the opening state of the low-pressure valve, wherein the pump control unit is configured to attain a conveying rate of the pump arrangement by means of a shift of a closing time of the low-pressure valve, wherein the closing time is shifted to an earlier time in order to increase the conveying rate and wherein the closing time is shifted to a later time in order to reduce the conveying rate, characterized in that the pump control unit is configured to detect gas in the pump chamber of the high-pressure pump on the basis of the opening state of the low-pressure valve and to increase the supply pressure if gas is present in the pump chamber, wherein, if the low-pressure valve opens at times at which it is not normally expected to open, this is a sign that it has not been possible to build up the required pressures in the pump chamber.
A substance which down-regulates the activity of a MAST4 gene for use in the prevention and/or treatment of an inflammatory skin condition in a mammalian subject wherein the substance acts at the nucleic acid level, down-regulating the transcription of a MAST4 gene and/or the translation of a MAST4 gene transcript.
A lyophilized degarelix drug substance consisting of degarelix, 4.5 to 10.0 % (w/w) acetic acid, a residual amount of water, and impurities due to the production process, if any, which shows, upon dissolution in water in an amount of 20 mg degarelix free base/ml of water containing 2.5 wt.% mannitol, a viscosity of up to 3.2 mPas, wherein the viscosity is measured using a rotating viscometer equipped with a cone-plate measuring system with D=60 mm and 1°, the shear rate being increased from 0 to 500 s-1 in 20 steps, using a controlled rate rotation step program at a constant temperature of 20+ -0.2°C.
An image forming apparatus, comprising: a main body; and a cover body which is openably/closably disposed in the main body, and exposes an inside of the main body when the cover body is in an open state; the cover body comprising: a first cover member which covers a part of one surface of the main body when the cover body is in a closed state; a second cover member having at least a rib or an opening portion; an engagement member which is engaged with the main body when the cover body is in the closed state; an elastic body which energizes the engagement member in a direction so that the engagement member is engaged with the body; and a support member which is fitted on the first cover member separately from the second cover member, rotatably supports the engagement member, and collides with the engagement member that is energized by the elastic body and is rotated when the cover body becomes in the closed state, to stop rotation of the engagement member characterized in that the support member and the second cover member are fitted on the first cover member in a state to be separated from each other. a main body; and a cover body which is openably/closably disposed in the main body, and exposes an inside of the main body when the cover body is in an open state; the cover body comprising: a first cover member which covers a part of one surface of the main body when the cover body is in a closed state; a second cover member having at least a rib or an opening portion; an engagement member which is engaged with the main body when the cover body is in the closed state; an elastic body which energizes the engagement member in a direction so that the engagement member is engaged with the body; and a support member which is fitted on the first cover member separately from the second cover member, rotatably supports the engagement member, and collides with the engagement member that is energized by the elastic body and is rotated when the cover body becomes in the closed state, to stop rotation of the engagement member characterized in that the support member and the second cover member are fitted on the first cover member in a state to be separated from each other. a first cover member which covers a part of one surface of the main body when the cover body is in a closed state; a second cover member having at least a rib or an opening portion; an engagement member which is engaged with the main body when the cover body is in the closed state; an elastic body which energizes the engagement member in a direction so that the engagement member is engaged with the body; and a support member which is fitted on the first cover member separately from the second cover member, rotatably supports the engagement member, and collides with the engagement member that is energized by the elastic body and is rotated when the cover body becomes in the closed state, to stop rotation of the engagement member characterized in that the support member and the second cover member are fitted on the first cover member in a state to be separated from each other.
Susceptor for the processing chamber of a protective-gas and vacuum high-temperature processing unit, comprising a circular segment greater than 180° as a body of a tunnel and comprising a base element (3, 7) which completes the circular segment to form a closed cross section, the tunnel being composed of at least two modules which are mounted on one another by their end faces and each consist of a circular segment and a base element (3, 7), characterised in that at least one end module is in the form of a monolithic body having a self-contained cross section consisting of a circular segment and a base surface.
A medical instrument, comprising: a shaft for insertion into a body of a patient; an inflatable balloon coupled to a distal end of the shaft; and a Radiofrequency ablation electrode, which is disposed on an external surface of the balloon and which has a distal edge configured to reduce electric field angular gradients of an RF electric field emitted from the distal edge, characterised in that the electrode comprises: an elongate main section that progressively narrows towards the distal edge; and a distal-end section, which is connected to a distal-most end of the main section and is wider than the main section at the distal-most end. a shaft for insertion into a body of a patient; an inflatable balloon coupled to a distal end of the shaft; and a Radiofrequency ablation electrode, which is disposed on an external surface of the balloon and which has a distal edge configured to reduce electric field angular gradients of an RF electric field emitted from the distal edge, characterised in that the electrode comprises: an elongate main section that progressively narrows towards the distal edge; and a distal-end section, which is connected to a distal-most end of the main section and is wider than the main section at the distal-most end. an elongate main section that progressively narrows towards the distal edge; and a distal-end section, which is connected to a distal-most end of the main section and is wider than the main section at the distal-most end.
A glass frit including SiO 2, B 2 O 3, ZnO, an I-group oxide, and further including NaF, wherein the SiO 2 is included by 15 wt% to 50 wt% of the entire glass frit, the B 2 O 3 is included by 10 wt% to 30 wt% of the entire glass frit, the ZnO is included by 5 wt% to 35 wt% of the entire glass frit, the I-group oxide is included by 10 wt% to 30 wt% of the entire glass frit, and includes Li 2 O, Na 2 O and K 2 O, the NaF is included by 1 wt% to 5 wt% of the entire glass frit, wherein the glass frit further includes Al 2 O 3, ZrO 2, and TiO 2, and wherein the Al 2 O 3, ZrO 2, and TiO 2 is included by 0.1 wt% to 5 wt% of the entire glass frit. wherein the SiO 2 is included by 15 wt% to 50 wt% of the entire glass frit, the B 2 O 3 is included by 10 wt% to 30 wt% of the entire glass frit, the ZnO is included by 5 wt% to 35 wt% of the entire glass frit, the I-group oxide is included by 10 wt% to 30 wt% of the entire glass frit, and includes Li 2 O, Na 2 O and K 2 O, the NaF is included by 1 wt% to 5 wt% of the entire glass frit, wherein the glass frit further includes Al 2 O 3, ZrO 2, and TiO 2, and wherein the Al 2 O 3, ZrO 2, and TiO 2 is included by 0.1 wt% to 5 wt% of the entire glass frit.
A method for forming a spiral particle separation device for separating particles within a fluid, the method comprising: forming a substrate (200, 300) having at least one channel (202, 302) formed therein; providing a first structure (208, 304) to a first end of the substrate; providing a second structure (212, 310) to a second end of the substrate, the second structure being operative as an outlet for the device; the at least one channel extending between the first and the second structure and, rolling the substrate around the first structure; wherein the second structure comprises a first outflow and a second outflow to provide two separate outflows of fluid from the second end of the substrate. forming a substrate (200, 300) having at least one channel (202, 302) formed therein; providing a first structure (208, 304) to a first end of the substrate; providing a second structure (212, 310) to a second end of the substrate, the second structure being operative as an outlet for the device; the at least one channel extending between the first and the second structure and, rolling the substrate around the first structure; wherein the second structure comprises a first outflow and a second outflow to provide two separate outflows of fluid from the second end of the substrate.
A force sensor, comprising: a first end portion; a second end portion; a parallel-guiding mechanism, the parallel-guiding mechanism being used for connecting the first end portion to the second end portion; a beam, the beam comprising a main beam, provided with a cavity arranged between an upper wall, a lower wall, a flexible left wall and a rigid right wall of the main beam; a first connecting part, for connecting the main beam to the first end portion, being a rigid beam; and a second connecting part, for connecting the main beam to the second end portion, being a flexible beam; wherein the flexible left wall is connected to the first connecting part, and the rigid right wall is connected to the second connecting part; and a strain gauge, the strain gauge being fixed to the flexible left wall. a first end portion; a second end portion; a parallel-guiding mechanism, the parallel-guiding mechanism being used for connecting the first end portion to the second end portion; a beam, the beam comprising a main beam, provided with a cavity arranged between an upper wall, a lower wall, a flexible left wall and a rigid right wall of the main beam; a first connecting part, for connecting the main beam to the first end portion, being a rigid beam; and a second connecting part, for connecting the main beam to the second end portion, being a flexible beam; wherein the flexible left wall is connected to the first connecting part, and the rigid right wall is connected to the second connecting part; and a main beam, provided with a cavity arranged between an upper wall, a lower wall, a flexible left wall and a rigid right wall of the main beam; a first connecting part, for connecting the main beam to the first end portion, being a rigid beam; and a second connecting part, for connecting the main beam to the second end portion, being a flexible beam; wherein the flexible left wall is connected to the first connecting part, and the rigid right wall is connected to the second connecting part; and a strain gauge, the strain gauge being fixed to the flexible left wall.
A carbon filler dispersant for dispersing a carbon filler in a liquid medium comprised of an aqueous solvent, comprising a hydroxyalkyl chitosan as a principal component, wherein the hydroxyalkyl chitosan has a weight average molecular weight of from 2,000 to 350,000, and wherein the hydroxyalkyl chitosan has a hydroxyalkylation degree of 0.5 or higher but 4 or lower.
An antibody that binds ENO1, or an scFv or Fab fragment thereof, comprising a heavy chain that comprises the sequences of HCDR1: GYTFTS CVMN; (SEQ ID NO:3), HCDR2:YINPYNDGTKYNEKFKG (SEQ ID NO:4), and HCDR3: EGFYYGNFDN (SEQ ID NO:5) and a light chain that comprises the sequences of LCDR1:RASENIYSYLT (SEQ ID NO:6), LCDR2: NAKTLPE (SEQ ID NO:7), and LCDR3:OHHYGTPYT (SEQ ID NO:8).
A micromechanical positioning device, comprising: - a micromechanical positioning actuator for causing movement of a probe with respect to a target, - a positioning controller, said positioning controller having an output, said output coupled to said actuator for controlling said movement, - said positioning controller having a steering input, said steering input arranged to be coupled to at least one other device over a local communication connection to receive one or more steering signals from said other device, said other device being a micromechanical positioning device, a measurement device or a stimulus device operating on said target, said local communication connection comprising a local communication network for carrying communication messages, and the local communication connection is an Ethernet connection, - said steering input comprises a communications controller operatively connectable to said communication network, and - said positioning controller arranged to control said movement based on said steering signals from said other device. - a micromechanical positioning actuator for causing movement of a probe with respect to a target, - a positioning controller, said positioning controller having an output, said output coupled to said actuator for controlling said movement, - said positioning controller having a steering input, said steering input arranged to be coupled to at least one other device over a local communication connection to receive one or more steering signals from said other device, said other device being a micromechanical positioning device, a measurement device or a stimulus device operating on said target, said local communication connection comprising a local communication network for carrying communication messages, and the local communication connection is an Ethernet connection, - said steering input comprises a communications controller operatively connectable to said communication network, and - said positioning controller arranged to control said movement based on said steering signals from said other device.
Process for oxidative cleavage of vegetable oils containing monounsaturated fatty acid triglycerides comprising: 1) a first step of hydroxylation of the double bond present in the monounsaturated fatty acid triglycerides in the presence of a catalyst comprising tungstic acid and/or its derivatives, to yield a vicinal diol, 2) a subsequent second step of oxidation of the vicinal diol in the presence of catalysts comprising cobalt salts, thereby obtaining a mixture comprising saturated monocarboxylic acids and saturated carboxylic acid triglycerides having more than one acid group, 3) a step of separation of an aqueous solution containing cobalt ions and tungstic acid and/or their derivatives from said mixture of step 2) and 4) a step of separation of cobalt ions from said aqueous solution of step 3) comprising the operations of: a) removing the cobalt ions by placing said aqueous solution in contact with a cation-exchange resin; b) separating said aqueous solution from said cation-exchange resin; c) concentrating said aqueous solution obtained from stage b, thereby obtaining a concentrated aqueous solution containing tungstic acid and/or its derivatives; d) eluting cobalt ions from the cation-exchange resin in stage b, using an acid aqueous solution. 1) a first step of hydroxylation of the double bond present in the monounsaturated fatty acid triglycerides in the presence of a catalyst comprising tungstic acid and/or its derivatives, to yield a vicinal diol, 2) a subsequent second step of oxidation of the vicinal diol in the presence of catalysts comprising cobalt salts, thereby obtaining a mixture comprising saturated monocarboxylic acids and saturated carboxylic acid triglycerides having more than one acid group, 3) a step of separation of an aqueous solution containing cobalt ions and tungstic acid and/or their derivatives from said mixture of step 2) and 4) a step of separation of cobalt ions from said aqueous solution of step 3) comprising the operations of: a) removing the cobalt ions by placing said aqueous solution in contact with a cation-exchange resin; b) separating said aqueous solution from said cation-exchange resin; c) concentrating said aqueous solution obtained from stage b, thereby obtaining a concentrated aqueous solution containing tungstic acid and/or its derivatives; d) eluting cobalt ions from the cation-exchange resin in stage b, using an acid aqueous solution. a) removing the cobalt ions by placing said aqueous solution in contact with a cation-exchange resin; b) separating said aqueous solution from said cation-exchange resin; c) concentrating said aqueous solution obtained from stage b, thereby obtaining a concentrated aqueous solution containing tungstic acid and/or its derivatives; d) eluting cobalt ions from the cation-exchange resin in stage b, using an acid aqueous solution.
Apparatus for unlocking a RAT actuator, the apparatus comprising: a first member mounted in a housing for rotation about an axis and having a circumferentially extending surface; and a second member for operative connection to a lock release element of the RAT actuator, arranged for movement in a direction generally transverse to the axis of rotation of the first member and having a follower element resiliently biased into contact with the circumferentially extending surface of the first member; characterised in that: a recess being formed in a section of the circumferentially extending surface of the first member; and by furher comprising: a rotary actuator for rotating the first member about the axis between a first, locking position in which the follower element engages on the circumferentially extending surface and a second, unlocking position in which the follower element is at least partially received within the recess. a first member mounted in a housing for rotation about an axis and having a circumferentially extending surface; and a second member for operative connection to a lock release element of the RAT actuator, arranged for movement in a direction generally transverse to the axis of rotation of the first member and having a follower element resiliently biased into contact with the circumferentially extending surface of the first member; characterised in that: a recess being formed in a section of the circumferentially extending surface of the first member; and by furher comprising: a rotary actuator for rotating the first member about the axis between a first, locking position in which the follower element engages on the circumferentially extending surface and a second, unlocking position in which the follower element is at least partially received within the recess.
Control valve arrangement of a fuel injector said arrangement comprising a valve body provided with a filling chamber in which, in use, pressurized fuel enters via a filling hole, a filling valve being arranged in said filling chamber for opening or closing a first fluid communication controlling, in use, the filling with pressurized fuel of a first control chamber, the filling valve having a filling valve member moving along a valve axis, said member having a head provided with a moving valve seat and, a stem slidably guided in a bore provided in the valve body, the filling valve member being normally biased open by a first spring; the valve arrangement being further provided with a control valve having a control valve member cooperating with an actuator for opening or closing a second fluid communication for controlling, in use, the emptying of the first control chamber, said control valve member being normally biased closed by a second spring, characterized in that a seat plug is arranged in the valve body for closing the filling chamber, said seat plug being provided with an opening provided with a fixed valve seat adapted to cooperate with said moving valve seat, said opening defining the first fluid communication between the filling chamber and the first control chamber.