A telescopic female drug vial adapter for use with a drug vial including a drug vial bottle containing a medicament and a drug vial rim defining a drug vial opening stopped by a drug vial stopper, the drug vial adapter having a longitudinal drug vial adapter axis and comprising: (a) a spike component including a transversely directed spike component top wall having i) a downward depending puncturing member with a puncturing tip for puncturing the drug vial stopper and an opposite upright female connector in flow communication with said puncturing member, and ii) at least two spaced apart downward depending spike component legs lateral to said puncturing member, said at least two spike component legs terminating at leg tips inwardly protruding toward said puncturing tip; and (b) a skirt component including a transversely directed skirt component top wall having a central aperture, a downward depending substantially cylindrical skirt of a multitude of drug vial flex members and a skirt component margin remote from said skirt component top wall, said multitude of drug vial flex members defining a drug vial rim cavity for snugly receiving the drug vial rim therein, at least two of said drug vial flex members having leg tip apertures for initially receiving said leg tips in a set-up position of the telescopic female drug vial adapter for initially spacing said spike component top wall from said skirt component top wall with said puncturing member protruding through said central aperture, the arrangement being such that on urging the drug vial adapter towards a drug vial positioned below said drug vial adapter and manual sliding displacement of said spike component towards said skirt component for stopping thereagainst in an actuated position of the telescopic female drug vial adapter, said drug vial flex members snugly receive the drug vial rim in said drug vial rim cavity, said puncturing member punctures the drug vial stopper and said leg tips are urged radial outward from their corresponding leg tip apertures to slide downward along their corresponding drug vial flex members towards said skirt component margin. (a) a spike component including a transversely directed spike component top wall having i) a downward depending puncturing member with a puncturing tip for puncturing the drug vial stopper and an opposite upright female connector in flow communication with said puncturing member, and ii) at least two spaced apart downward depending spike component legs lateral to said puncturing member, said at least two spike component legs terminating at leg tips inwardly protruding toward said puncturing tip; and i) a downward depending puncturing member with a puncturing tip for puncturing the drug vial stopper and an opposite upright female connector in flow communication with said puncturing member, and ii) at least two spaced apart downward depending spike component legs lateral to said puncturing member, said at least two spike component legs terminating at leg tips inwardly protruding toward said puncturing tip; and (b) a skirt component including a transversely directed skirt component top wall having a central aperture, a downward depending substantially cylindrical skirt of a multitude of drug vial flex members and a skirt component margin remote from said skirt component top wall,