An intravenous device adapter for efficient prevention of contamination of an access port, the intravenous device adapter comprising: a body having a proximal end and a distal end, the proximal end having a first coupling surface for receiving a first intravenous device, and the distal end having a second coupling surface for receiving a second intravenous device, the body further including a channel having a proximal end and a distal end; a cap having an inner surface configured to contact the proximal end of the body; an antimicrobial agent disposed within the inner surface of the cap, the antimicrobial agent being selected from the group of chlorhexidine gluconate, chlorhexidine acetate, PCMX, Triclosan, silver sulfadiazine, or comprises a topical antibiotic, such as Mupirocin, bacitracine, characterized by a tether (80, 130) connecting the cap to the body, the tether (80, 130) having a loop (82, 132) at a distal end, the loop (82, 132) extending around the channel to secure the tether (80, 130) to the body, the loop (82, 132) having a width that is less than a width of the channel such that the loop (82, 132) is slidable within the channel between the proximal end and the distal end of the channel, wherein the tether (80, 130) has a length such that, when the loop (82, 132) is at the proximal end of the channel, the cap can be coupled to or removed from the proximal end of the body, and when the loop (82, 132) is at the distal end of the channel, the cap, when not coupled to the proximal end of the body, cannot be coupled to the proximal end of the body or, when coupled to the proximal end of the body, cannot be removed from the proximal end of the body. a body having a proximal end and a distal end, the proximal end having a first coupling surface for receiving a first intravenous device, and the distal end having a second coupling surface for receiving a second intravenous device, the body further including a channel having a proximal end and a distal end; a cap having an inner surface configured to contact the proximal end of the body; an antimicrobial agent disposed within the inner surface of the cap, the antimicrobial agent being selected from the group of chlorhexidine gluconate, chlorhexidine acetate, PCMX, Triclosan, silver sulfadiazine, or comprises a topical antibiotic, such as Mupirocin, bacitracine, characterized by a tether (80, 130) connecting the cap to the body, the tether (80, 130) having a loop (82, 132) at a distal end, the loop (82, 132) extending around the channel to secure the tether (80, 130) to the body, the loop (82, 132) having a width that is less than a width of the channel such that the loop (82, 132) is slidable within the channel between the proximal end and the distal end of the channel, wherein the tether (80, 130) has a length such that, when the loop (82, 132) is at the proximal end of the channel, the cap can be coupled to or removed from the proximal end of the body, and when the loop (82, 132) is at the distal end of the channel, the cap, when not coupled to the proximal end of the body, cannot be coupled to the proximal end of the body or, when coupled to the proximal end of the body, cannot be removed from the proximal end of the body.