A lipstick tube with a replaceable mechanism, comprising a base and the replaceable mechanism, wherein the replaceable mechanism comprises a barrel, a fork, a spiral component and an aluminum shell, wherein the barrel, the fork, the spiral component and the aluminum shell are coaxially sleeved sequentially from inside out, a barrel engaging member integrally protrudes from an outer side wall of the barrel, a hollow guide groove extending in an axial direction of the fork is formed in the fork, a spiral guide groove extending in an axial direction of the spiral component and spiraling upward is formed in an inner side wall of the spiral component, the barrel engaging member is configured for passing through the hollow guide groove and then being embedded into and sliding in the spiral guide groove, the spiral component is configured for axially stopping and circumferentially rotating relative to the fork, and the aluminum shell is configured for being fixed in position relative to the spiral component; and a bottom of the fork is configured for being detachably engaged on the base, and the fork is configured for circumferentially stopping relative to the base; characterized in that the base comprises: a base casing in a hollow cylindrical shape and with an open upper shaft end, a base inner column integrally formed on an inner surface of a lower shaft end of the base casing and extending in an axial direction of the base casing, and a receiving cavity formed between the base casing and the base inner column; wherein a circle of barb ribs are formed in an inner side wall of the base casing, and a circle of first anti-rotation teeth are formed at an upper part of an outer side wall of the base inner column; the fork comprises a fork body, the fork body is of a first hollow cylindrical structure with an open upper shaft end and an open lower shaft end, a plurality of separation grooves extending in an axial direction of the fork body and opening at the open lower shaft end of the fork body are formed at a bottom of the fork body, and the plurality of separation grooves are arranged in a first ring row to separate the bottom of the fork body into a plurality of elastic members; the plurality of elastic members comprise a plurality of first elastic members and a plurality of second elastic members, wherein the plurality of first elastic members and the plurality of second elastic members are alternately distributed in sequence, a plurality of elastic hooks are respectively integrally formed on outer side walls of the plurality of first elastic members, and a convex rib is integrally formed on an outer side wall of each of the plurality of second elastic members; and an inner side wall of the fork body extends radially inward at a position adjacent to the plurality of separation grooves to form a convex ring, and a circle of second anti-rotation teeth are formed on an inner wall of the convex ring; and when the bottom of the fork body is inserted into the receiving cavity, the plurality of elastic hooks are configured for being respectively engaged with the barb ribs, and the second anti-rotation teeth are configured for being connected to the first anti-rotation teeth in an anti-rotation fit. a base casing in a hollow cylindrical shape and with an open upper shaft end, a base inner column integrally formed on an inner surface of a lower shaft end of the base casing and extending in an axial direction of the base casing, and a receiving cavity formed between the base casing and the base inner column; wherein a circle of barb ribs are formed in an inner side wall of the base casing, and a circle of first anti-rotation teeth are formed at an upper part of an outer side wall of the base inner column; the fork comprises a fork body, the fork body is of a first hollow cylindrical structure with an open upper shaft end and an open lower shaft end, a plurality of separation grooves extending in an axial direction of the fork body and opening at the open lower shaft end of the fork body are formed at a bottom of the fork body, and the plurality of separation grooves are arranged in a first ring row to separate the bottom of the fork body into a plurality of elastic members; the plurality of elastic members comprise a plurality of first elastic members and a plurality of second elastic members, wherein the plurality of first elastic members and the plurality of second elastic members are alternately distributed in sequence, a plurality of elastic hooks are respectively integrally formed on outer side walls of the plurality of first elastic members, and a convex rib is integrally formed on an outer side wall of each of the plurality of second elastic members; and an inner side wall of the fork body extends radially inward at a position adjacent to the plurality of separation grooves to form a convex ring, and a circle of second anti-rotation teeth are formed on an inner wall of the convex ring; and when the bottom of the fork body is inserted into the receiving cavity, the plurality of elastic hooks are configured for being respectively engaged with the barb ribs, and the second anti-rotation teeth are configured for being connected to the first anti-rotation teeth in an anti-rotation fit.