A compound which is of Formula: where R 1 is -NR 5 R 5a; R 2a is halo or C 1 -C 6 alkyl; R 2 is -S-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or halo; X 1 is C 1 -C 6 alkyl; R 3, R 3a, and R 3b are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -S-C 1 -C 6 alkyl, halo, C 1 -C 6 alkoxy, C 3 -C 8 -cycloalkyloxy, -O(heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), - O(heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), or phenoxy where each phenyl and heteroaryl is independently optionally substituted with 1, 2, or 3 R 6; R 5 is -OR 5b; R 5a is hydrogen; R 5b is C 3 -C 8 cycloalkyl-C 1 -C 6 -alkyl, or unbranched C 1 -C 6 hydroxyalkyl, where the C 1 -C 6 alkyl in the C 1 -C 6 hydroxyalkyl is substituted with one hydroxy; each R 6 is independently selected from the group consisting of carboxy, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, -OC R 7, -OS 2 R 7, -O-C 1 -C 6 -haloalkyl, C 3 -C 8 cycloalkyloxy, -O(heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), -O(6 to 14-membered aryl), -O(heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, - NR 8a S 2 R 8, -NR 8a C R 8, -S 2 R 8, -S 2 NR 8a R 8, -C R 8, -C NR 8a R 8, and - C 1 -C 6 -alkylene-R 6a; each R 6a is independently selected from the group consisting of C 3 -C 8 cycloalkyl, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, -NH 2, -NH(C 1 -C 6 -alkyl), -N(C 1 -C 6 -alkyl) 2, -NR 9a S 2 R 9, -NR 9a C R 9, -S 2 R 9, -S 2 NR 9a R 9, -C R 9, and -C NR 9a R 9; each R 7 is independently selected from the group consisting of amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 -alkoxy, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, 6 to 14-membered aryl, and heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N; each R 8a and R 9a is independently H or C 1-6 alkyl; each R 8 and R 9 is independently C 1 -C 6 alkyl, 6 to 14-membered aryl, heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, C 3 -C 8 cycloalkyl, or heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N; or is an N-oxide, a stereoisomer, mixture of stereoisomers, and/or a pharmaceutically acceptable salt thereof. R 1 is -NR 5 R 5a; R 2a is halo or C 1 -C 6 alkyl; R 2 is -S-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or halo; X 1 is C 1 -C 6 alkyl; R 3, R 3a, and R 3b are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -S-C 1 -C 6 alkyl, halo, C 1 -C 6 alkoxy, C 3 -C 8 -cycloalkyloxy, -O(heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), - O(heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), or phenoxy where each phenyl and heteroaryl is independently optionally substituted with 1, 2, or 3 R 6; R 5 is -OR 5b; R 5a is hydrogen; R 5b is C 3 -C 8 cycloalkyl-C 1 -C 6 -alkyl, or unbranched C 1 -C 6 hydroxyalkyl, where the C 1 -C 6 alkyl in the C 1 -C 6 hydroxyalkyl is substituted with one hydroxy; each R 6 is independently selected from the group consisting of carboxy, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, -OC R 7, -OS 2 R 7, -O-C 1 -C 6 -haloalkyl, C 3 -C 8 cycloalkyloxy, -O(heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), -O(6 to 14-membered aryl), -O(heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N), amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, - NR 8a S 2 R 8, -NR 8a C R 8, -S 2 R 8, -S 2 NR 8a R 8, -C R 8, -C NR 8a R 8, and - C 1 -C 6 -alkylene-R 6a; each R 6a is independently selected from the group consisting of C 3 -C 8 cycloalkyl, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, -NH 2, -NH(C 1 -C 6 -alkyl), -N(C 1 -C 6 -alkyl) 2, -NR 9a S 2 R 9, -NR 9a C R 9, -S 2 R 9, -S 2 NR 9a R 9, -C R 9, and -C NR 9a R 9; each R 7 is independently selected from the group consisting of amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 -alkoxy, heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, 6 to 14-membered aryl, and heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N; each R 8a and R 9a is independently H or C 1-6 alkyl; each R 8 and R 9 is independently C 1 -C 6 alkyl, 6 to 14-membered aryl, heteroaryl having 5 or 6 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N, C 3 -C 8 cycloalkyl, or heterocycloalkyl having 3 to 20 ring atoms and 1 to 4 heteroatoms selected from O, S 0-2 and N; or is an N-oxide, a stereoisomer, mixture of stereoisomers, and/or a pharmaceutically acceptable salt thereof.