A bi-directional gas flow generation system, the system comprising: (a) a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject, the pressure generator comprising: an inlet configured to receive breathable gas into the pressure generator; and an outlet configured to output the pressurized flow of breathable gas from the pressure generator; (b) a flow member configured to communicate with the pressure generator and a respiratory circuit, the flow member comprising: an outlet port coupled with the pressure generator inlet; an inlet port coupled with the pressure generator outlet; a respiratory circuit port coupled with the respiratory circuit; and a flow path that places the respiratory circuit in fluid communication with the pressure generator by connecting the flow member outlet port and the flow member inlet port to the respiratory circuit port; (c) a first valve configured to selectively control flow through the flow path between the respiratory circuit port and the flow member outlet port; (d) a second valve that is mechanically separate and discrete from the first valve, and is configured to selectively control flow through the flow path between the flow member inlet port and the respiratory circuit port; (e) a processor configured to selectively control the first valve and the second valve to operate in (i) a first mode in which gas flows from the flow member inlet port to the respiratory circuit port, thereby creating a positive pressure at the respiratory circuit port to insufflate the subject; and (ii) a second mode in which gas flows from the respiratory circuit port to the flow member outlet port, thereby creating a negative pressure at the respiratory circuit port facilitating gas flow out from the airway of the subject to exsufflate the subject, wherein the processor is configured to control the pressure generator, the first valve, and/or the second valve to generate the flow of gas in accordance with a ventilator regime, and a mechanical inexsufflation regime. (a) a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject, the pressure generator comprising: an inlet configured to receive breathable gas into the pressure generator; and an outlet configured to output the pressurized flow of breathable gas from the pressure generator; an inlet configured to receive breathable gas into the pressure generator; and an outlet configured to output the pressurized flow of breathable gas from the pressure generator; (b) a flow member configured to communicate with the pressure generator and a respiratory circuit, the flow member comprising: an outlet port coupled with the pressure generator inlet; an inlet port coupled with the pressure generator outlet; a respiratory circuit port coupled with the respiratory circuit; and a flow path that places the respiratory circuit in fluid communication with the pressure generator by connecting the flow member outlet port and the flow member inlet port to the respiratory circuit port; an outlet port coupled with the pressure generator inlet; an inlet port coupled with the pressure generator outlet; a respiratory circuit port coupled with the respiratory circuit; and a flow path that places the respiratory circuit in fluid communication with the pressure generator by connecting the flow member outlet port and the flow member inlet port to the respiratory circuit port; (c) a first valve configured to selectively control flow through the flow path between the respiratory circuit port and the flow member outlet port; (d) a second valve that is mechanically separate and discrete from the first valve, and is configured to selectively control flow through the flow path between the flow member inlet port and the respiratory circuit port; (e) a processor configured to selectively control the first valve and the second valve to operate in (i) a first mode in which gas flows from the flow member inlet port to the respiratory circuit port, thereby creating a positive pressure at the respiratory circuit port to insufflate the subject; and (ii) a second mode in which gas flows from the respiratory circuit port to the flow member outlet port, thereby creating a negative pressure at the respiratory circuit port facilitating gas flow out from the airway of the subject to exsufflate the subject, wherein the processor is configured to control the pressure generator, the first valve, and/or the second valve to generate the flow of gas in accordance with a ventilator regime, and a mechanical inexsufflation regime.