An ultrasonic diagnosis apparatus for acquiring an ultrasonic image by scanning a subject administered with bubbles of a contrast medium by an ultrasonic wave, said ultrasonic diagnosis apparatus characterized by comprising: an ultrasonic probe for transmitting the ultrasonic wave to the subject and receiving an echo signal from the subject; and a signal generating unit for generating a drive signal for driving the ultrasonic probe characterized in that the apparatus further comprises: a controller for setting a region of irradiating a first ultrasonic wave having a first sound pressure to a degree of destructing the bubbles of the contrast medium based on an instruction of an operator, the region corresponding to a part of an interest region such that the first ultrasonic wave is adapted to destructing the bubbles of the contrast medium in the said region corresponding to a part of an interest region and not substantially destructing the bubbles in the remainder of the interest region and thus restraining bubbles of the contrast medium from flowing into the desired blood vessel associated with the region, and for controlling the drive signal generating unit to execute a scan of the interest region by switching between a first transmission for transmitting the first ultrasonic wave having the first sound pressure to the region, a second transmission for transmitting a second ultrasonic wave having a second sound pressure to a degree of destructing the bubbles of the contrast medium to almost whole region of the interest region and a third transmission for transmitting a third ultrasonic wave having a third sound pressure to a degree of not substantially destructing the bubbles of the contrast medium to the almost whole region of the interest region, and a display for displaying an image which is generated based on a reflected wave of the third ultrasonic of the third transmission, wherein the probe executes the first to third transmissions in the order of the second transmission, the first transmission and the third transmission. an ultrasonic probe for transmitting the ultrasonic wave to the subject and receiving an echo signal from the subject; and a signal generating unit for generating a drive signal for driving the ultrasonic probe characterized in that the apparatus further comprises: a controller for setting a region of irradiating a first ultrasonic wave having a first sound pressure to a degree of destructing the bubbles of the contrast medium based on an instruction of an operator, the region corresponding to a part of an interest region such that the first ultrasonic wave is adapted to destructing the bubbles of the contrast medium in the said region corresponding to a part of an interest region and not substantially destructing the bubbles in the remainder of the interest region and thus restraining bubbles of the contrast medium from flowing into the desired blood vessel associated with the region, and for controlling the drive signal generating unit to execute a scan of the interest region by switching between a first transmission for transmitting the first ultrasonic wave having the first sound pressure to the region, a second transmission for transmitting a second ultrasonic wave having a second sound pressure to a degree of destructing the bubbles of the contrast medium to almost whole region of the interest region and a third transmission for transmitting a third ultrasonic wave having a third sound pressure to a degree of not substantially destructing the bubbles of the contrast medium to the almost whole region of the interest region, and a display for displaying an image which is generated based on a reflected wave of the third ultrasonic of the third transmission, a controller for setting a region of irradiating a first ultrasonic wave having a first sound pressure to a degree of destructing the bubbles of the contrast medium based on an instruction of an operator, the region corresponding to a part of an interest region such that the first ultrasonic wave is adapted to destructing the bubbles of the contrast medium in the said region corresponding to a part of an interest region and not substantially destructing the bubbles in the remainder of the interest region and thus restraining bubbles of the contrast medium from flowing into the desired blood vessel associated with the region, and for controlling the drive signal generating unit to execute a scan of the interest region by switching between a first transmission for transmitting the first ultrasonic wave having the first sound pressure to the region, a second transmission for transmitting a second ultrasonic wave having a second sound pressure to a degree of destructing the bubbles of the contrast medium to almost whole region of the interest region and a third transmission for transmitting a third ultrasonic wave having a third sound pressure to a degree of not substantially destructing the bubbles of the contrast medium to the almost whole region of the interest region, and a display for displaying an image which is generated based on a reflected wave of the third ultrasonic of the third transmission, wherein the probe executes the first to third transmissions in the order of the second transmission, the first transmission and the third transmission.