A portable cooler container system, comprising: a container body having a chamber configured to receive one or more temperature sensitive products; a sleeve disposed about the chamber and housing a phase change material or thermal mass; a conduit extending through the sleeve, an outer surface of the conduit in thermal communication with the phase change material or thermal mass; a lid hingedly coupleable or removably coupleable to the container body to access the chamber; a temperature control system comprising a cold side heat sink in thermal communication with at least a portion of the conduit, a hot side heat sink, a thermoelectric module interposed between and in thermal communication with the cold side heat sink and hot side heat sink, a pump operable to flow a fluid relative to the cold side heat sink to cool the fluid and to flow the cooled fluid through the conduit in the sleeve to cool the phase change material or thermal mass so that the phase change material or thermal mass is configured to cool at least a portion of the chamber, and circuitry configured to control an operation of one or both of the thermoelectric module and the pump; characterised in that the portable cooler container system comprises: a display screen configured to selectively display shipping information for the portable cooler container; and a button or touch screen manually actuatable by a user to automatically switch sender and recipient information on the display screen to facilitate return of the portable cooler container to a sender. a container body having a chamber configured to receive one or more temperature sensitive products; a sleeve disposed about the chamber and housing a phase change material or thermal mass; a conduit extending through the sleeve, an outer surface of the conduit in thermal communication with the phase change material or thermal mass; a lid hingedly coupleable or removably coupleable to the container body to access the chamber; a temperature control system comprising a cold side heat sink in thermal communication with at least a portion of the conduit, a hot side heat sink, a thermoelectric module interposed between and in thermal communication with the cold side heat sink and hot side heat sink, a pump operable to flow a fluid relative to the cold side heat sink to cool the fluid and to flow the cooled fluid through the conduit in the sleeve to cool the phase change material or thermal mass so that the phase change material or thermal mass is configured to cool at least a portion of the chamber, and circuitry configured to control an operation of one or both of the thermoelectric module and the pump; characterised in that the portable cooler container system comprises: a cold side heat sink in thermal communication with at least a portion of the conduit, a hot side heat sink, a thermoelectric module interposed between and in thermal communication with the cold side heat sink and hot side heat sink, a pump operable to flow a fluid relative to the cold side heat sink to cool the fluid and to flow the cooled fluid through the conduit in the sleeve to cool the phase change material or thermal mass so that the phase change material or thermal mass is configured to cool at least a portion of the chamber, and circuitry configured to control an operation of one or both of the thermoelectric module and the pump; characterised in that the portable cooler container system comprises: a display screen configured to selectively display shipping information for the portable cooler container; and a button or touch screen manually actuatable by a user to automatically switch sender and recipient information on the display screen to facilitate return of the portable cooler container to a sender.