mhurhangee/ep-ind-claims huggingface dataset:
A composition for use in treating cancer in a patient comprising administering to the patient in need thereof: (i) an effective amount of an ActRIIB antagonist, wherein the ActRIIB antagonist is an ActRIIB-Fc fusion protein comprising an amino acid sequence of SEQ ID NO: 58; and (ii) an effective amount of a TGFβ antagonist, wherein the TGFβ antagonist comprises a pan-specific antibody that binds TGFβ1, TGFβ2, and TGFβ3, and wherein the cancer is leukemia. (i) an effective amount of an ActRIIB antagonist, wherein the ActRIIB antagonist is an ActRIIB-Fc fusion protein comprising an amino acid sequence of SEQ ID NO: 58; and (ii) an effective amount of a TGFβ antagonist, wherein the TGFβ antagonist comprises a pan-specific antibody that binds TGFβ1, TGFβ2, and TGFβ3, and wherein the cancer is leukemia.
A rotor for use with a stator having end-windings, the rotor comprising: a hollow cylindrical body having an inner wall, an outer wall, a first distal end, and a second distal end; a first shaft portion coupled to the first distal end of the hollow cylindrical body; a second shaft portion coupled to the second distal end of the hollow cylindrical body, the second shaft portion including a fluid feed tube formed therewith having a fluid receive end and a fluid feed end, the fluid feed end extending to a central inner portion of the hollow cylindrical body; and a plurality of fluid exit ports adjacent the first distal end and the second distal end of the hollow cylindrical body, wherein the fluid feed end of the fluid feed tube comprises a plurality of fluid spray ports formed in the second shaft portion and configured to spray fluid onto the inner wall of the hollow cylindrical body, the fluid further flowing along the inner wall of the hollow cylindrical body from a central portion towards the plurality of fluid exit ports when the rotor is rotating, said fluid exit ports being configured to spray fluid onto at least the end-windings of the stator when the rotor is rotating, characterized in that a distance towards an axis of rotation of the rotor from the inner wall of the hollow cylindrical body to the plurality of fluid exit ports is based upon a specified fluid film thickness to support rotor cooling. a hollow cylindrical body having an inner wall, an outer wall, a first distal end, and a second distal end; a first shaft portion coupled to the first distal end of the hollow cylindrical body; a second shaft portion coupled to the second distal end of the hollow cylindrical body, the second shaft portion including a fluid feed tube formed therewith having a fluid receive end and a fluid feed end, the fluid feed end extending to a central inner portion of the hollow cylindrical body; and a plurality of fluid exit ports adjacent the first distal end and the second distal end of the hollow cylindrical body, wherein the fluid feed end of the fluid feed tube comprises a plurality of fluid spray ports formed in the second shaft portion and configured to spray fluid onto the inner wall of the hollow cylindrical body, the fluid further flowing along the inner wall of the hollow cylindrical body from a central portion towards the plurality of fluid exit ports when the rotor is rotating, said fluid exit ports being configured to spray fluid onto at least the end-windings of the stator when the rotor is rotating, characterized in that a distance towards an axis of rotation of the rotor from the inner wall of the hollow cylindrical body to the plurality of fluid exit ports is based upon a specified fluid film thickness to support rotor cooling.
A liquid detergent composition having a surfactant concentration of ≥30% by weight based on the total weight of the composition, preferably in the range of 30-45% by weight, more preferably 32-38% by weight, and a polymeric constituent concentration of ≥2% by weight based on the total weight of the composition, preferably 2-10% by weight, more preferably 3-5% by weight, characterized in that the composition contains a surfactant system comprising nonionic surfactants in an amount of 5-20% by weight based on the total weight of the composition, preferably 8-15% by weight.% by weight based on the total weight of the composition, preferably 8-15% by weight, wherein the nonionic surfactants comprise at least one alkyl ether and at least one alkyl (poly)glycoside, wherein the weight ratio of alkyl ether to alkyl (poly)glycoside is 1:2 to 5:1, preferably 1:1 to 3:1, wherein the at least one alkyl ether is a fatty alcohol alkoxylate.
A combination backpack and medical fluid bag support (10, 10', 10"), comprising: a medical fluid bag support (10, 10', 10") comprising a base assembly (18, 18', 18") having at least one selectively adjustable foot (28, 28', 28"), and means for attaching a medical device comprising a medical pump to the base assembly (18, 18', 18"), a pole assembly (20, 20', 20") coupled to the base assembly (18, 18', 18"), the pole assembly (20, 20', 20") having a medical fluid bag attachment portion configured to support a feeding bag thereunto and means for disposing the medical fluid bag attachment portion at at least one predetermined head height above said means for attaching the medical device; and a backpack portion configured to be supported on a wearer's shoulder and defining an internal storage compartment sized to receive therein the medical fluid bag support (10, 10', 10"); characterized in that the medical fluid bag support (10, 10', 10") is in an upright position such that the backpack portion allows the wearer to be mobile while using the medical fluid bag support (10, 10', 10") and the medical pump mounted on the medical fluid bag support (10, 10', 10") for fluid infusion. a medical fluid bag support (10, 10', 10") comprising a base assembly (18, 18', 18") having at least one selectively adjustable foot (28, 28', 28"), and means for attaching a medical device comprising a medical pump to the base assembly (18, 18', 18"), a pole assembly (20, 20', 20") coupled to the base assembly (18, 18', 18"), the pole assembly (20, 20', 20") having a medical fluid bag attachment portion configured to support a feeding bag thereunto and means for disposing the medical fluid bag attachment portion at at least one predetermined head height above said means for attaching the medical device; and a backpack portion configured to be supported on a wearer's shoulder and defining an internal storage compartment sized to receive therein the medical fluid bag support (10, 10', 10"); characterized in that the medical fluid bag support (10, 10', 10") is in an upright position such that the backpack portion allows the wearer to be mobile while using the medical fluid bag support (10, 10', 10") and the medical pump mounted on the medical fluid bag support (10, 10', 10") for fluid infusion.
A method of synthesizing n-mer oligonucleotides on a substrate, comprising: (a) providing a substrate with individual resolved loci in the form of microstructures that are functionalized with a chemical moiety suitable for nucleotide coupling; and (b) coupling at least two nucleotide building blocks to a plurality of growing individual oligonucleotide chains each residing on one of the individual resolved loci at a rate of at least 10 nucleotides per hour according to a locus specific predetermined sequence, thereby synthesizing a plurality of oligonucleotides that are n base pairs long, and wherein the plurality of oligonucleotides on the substrate deviate from respective locus specific predetermined sequences at an error rate of less than 1/1000 bp, wherein the building blocks comprise a nucleotide, a dinucleotide or a trinucleotide and (c) cleaving the synthesized oligonucleotides from the substrate, wherein n is at least 100. (a) providing a substrate with individual resolved loci in the form of microstructures that are functionalized with a chemical moiety suitable for nucleotide coupling; and (b) coupling at least two nucleotide building blocks to a plurality of growing individual oligonucleotide chains each residing on one of the individual resolved loci at a rate of at least 10 nucleotides per hour according to a locus specific predetermined sequence, thereby synthesizing a plurality of oligonucleotides that are n base pairs long, and wherein the plurality of oligonucleotides on the substrate deviate from respective locus specific predetermined sequences at an error rate of less than 1/1000 bp, wherein the building blocks comprise a nucleotide, a dinucleotide or a trinucleotide and (c) cleaving the synthesized oligonucleotides from the substrate,
Method for verifying the centration of spectacles worn by a spectacle wearer, comprising the steps of: a) measuring spectacle lenses (12R, 12L) mounted in a frame of the spectacles, wherein a position of permanent markings (14R1, 14R2, 14L1, 14L2) on the spectacle lenses (12R, 12L) is captured by means of an image recognition system relative to a coordinate system defined by rims (22R, 22L); b) ascertaining positions of intended centration points (16R, 16L, 18R, 18L), specified in a file, of the spectacle lenses (12R, 12L) on the basis of data of the spectacle lenses containing the position of the permanent markings (14R1, 14R2, 14L1, 14L2); c) measuring physiological data of a spectacle wearer wearing the spectacles and ascertaining positions of actual centration points of the spectacle lenses (12R, 12L) from the physiological data by means of a video centration device, wherein the physiological data are a position of the pupil centres and an interpupillary distance, and wherein a refraction of the spectacle lenses (12R, 12L) is removed by calculation; d) ascertaining the difference between the positions of the intended centration points (16R, 16L, 18R, 18L) and the actual centration points; and e) comparing the difference to a specified difference threshold. a) measuring spectacle lenses (12R, 12L) mounted in a frame of the spectacles, wherein a position of permanent markings (14R1, 14R2, 14L1, 14L2) on the spectacle lenses (12R, 12L) is captured by means of an image recognition system relative to a coordinate system defined by rims (22R, 22L); b) ascertaining positions of intended centration points (16R, 16L, 18R, 18L), specified in a file, of the spectacle lenses (12R, 12L) on the basis of data of the spectacle lenses containing the position of the permanent markings (14R1, 14R2, 14L1, 14L2); c) measuring physiological data of a spectacle wearer wearing the spectacles and ascertaining positions of actual centration points of the spectacle lenses (12R, 12L) from the physiological data by means of a video centration device, wherein the physiological data are a position of the pupil centres and an interpupillary distance, and wherein a refraction of the spectacle lenses (12R, 12L) is removed by calculation; d) ascertaining the difference between the positions of the intended centration points (16R, 16L, 18R, 18L) and the actual centration points; and e) comparing the difference to a specified difference threshold.
An embolisation device for promoting clot formation in a bodily lumen and having a collapsed delivery configuration for delivery of the embolisation device into, and retrieval of the embolisation device from, the bodily lumen and an expanded deployed configuration for anchoring the embolisation device in the bodily lumen, the embolisation device comprising: a tubular cage having a collapsed delivery configuration and an expanded deployed configuration; and an embolisation member disposed in the tubular cage, the embolisation member comprising a stem and a plurality of flexible bristles extending outwardly from the stem, the plurality of flexible bristles having a collapsed delivery configuration and an expanded deployed configuration, wherein the embolisation device is configured such that as the tubular cage is transitioned from its expanded deployed configuration to its collapsed delivery configuration the plurality of flexible bristles is urged by the tubular cage from the expanded deployed configuration of the flexible bristles to the collapsed delivery configuration of the flexible bristles, wherein in the expanded deployed configuration of the embolisation device a first segment of the plurality of flexible bristles points in one direction along the longitudinal axis of the tubular cage, and wherein in the collapsed delivery configuration of the embolisation device the first segment of the plurality of flexible bristles points in the same direction. a tubular cage having a collapsed delivery configuration and an expanded deployed configuration; and an embolisation member disposed in the tubular cage, the embolisation member comprising a stem and a plurality of flexible bristles extending outwardly from the stem, the plurality of flexible bristles having a collapsed delivery configuration and an expanded deployed configuration, wherein the embolisation device is configured such that as the tubular cage is transitioned from its expanded deployed configuration to its collapsed delivery configuration the plurality of flexible bristles is urged by the tubular cage from the expanded deployed configuration of the flexible bristles to the collapsed delivery configuration of the flexible bristles, wherein in the expanded deployed configuration of the embolisation device a first segment of the plurality of flexible bristles points in one direction along the longitudinal axis of the tubular cage, and wherein in the collapsed delivery configuration of the embolisation device the first segment of the plurality of flexible bristles points in the same direction.
A freeze-dried, aerated product comprising: a fruit or vegetable ingredient in an amount of from 60 to 98%, and a lactylated mono and diglyceride in an amount of from 0.001 to 1%, wherein the product has a hardness value of from 2.2 to 35.6 N, wherein hardness is defined as the peak stress prior to fracturing a material, a dissolvability in the range of from 0.44 and 35.6 N peak load, wherein the dissolvability is measured as the change in hardness in going from a dry to a wet state, and a viscosity of from 1000 to 100,000cp. a fruit or vegetable ingredient in an amount of from 60 to 98%, and a lactylated mono and diglyceride in an amount of from 0.001 to 1%, wherein the product has a hardness value of from 2.2 to 35.6 N, wherein hardness is defined as the peak stress prior to fracturing a material, a dissolvability in the range of from 0.44 and 35.6 N peak load, wherein the dissolvability is measured as the change in hardness in going from a dry to a wet state, and a viscosity of from 1000 to 100,000cp.
Multilayer stack, of use in forming a photovoltaic device, of NIP or PIN structure, said stack having a planar architecture and comprising at least: - a semiconductor layer, referred to as lower semiconductor layer, of N type in the case of an NIP structure, or of P type in the case of a PIN structure; and - a composite layer, superposed on said lower conductive layer, comprising at least one perovskite material and at least one P-type material in the case of an NIP structure or of N type in the case of a PIN structure, and having a gradient of the P material/perovskite material weight ratio in the case of an NIP structure or N material/perovskite material weight ratio in the case of a PIN structure, in the direction from the interface between said composite layer and said lower semiconductor layer towards the opposite face of said composite layer; said perovskite material and said P-type or N-type material forming within said composite layer, over a thickness of at least 10 nm, an interpenetrated structure, said interpenetrated structure being formed of a matrix based on said P-type or N-type material, in which crystalline perovskite domains are incorporated, and said composite layer being formed by successive wet deposition of said perovskite and P-type or N-type materials, before crystallization of the perovskite, said stack having a planar architecture. - a semiconductor layer, referred to as lower semiconductor layer, of N type in the case of an NIP structure, or of P type in the case of a PIN structure; and - a composite layer, superposed on said lower conductive layer, comprising at least one perovskite material and at least one P-type material in the case of an NIP structure or of N type in the case of a PIN structure, and having a gradient of the P material/perovskite material weight ratio in the case of an NIP structure or N material/perovskite material weight ratio in the case of a PIN structure, in the direction from the interface between said composite layer and said lower semiconductor layer towards the opposite face of said composite layer; said perovskite material and said P-type or N-type material forming within said composite layer, over a thickness of at least 10 nm, an interpenetrated structure, said interpenetrated structure being formed of a matrix based on said P-type or N-type material, in which crystalline perovskite domains are incorporated, and said composite layer being formed by successive wet deposition of said perovskite and P-type or N-type materials, before crystallization of the perovskite, said stack having a planar architecture.
A substituted cyclodextrin of formula: wherein n is an integer from 3 to 7 and R is selected from the group consisting of-COOH, -OH and -COO alkyl, and wherein p + q is 6, 7 or 8, whereby p is 5 and q is 1, or p is 6 and q is 1, or p is 7 and q is 1, or p is 0 and q is 6, or p is 0 and q is 7, or p is 0 and q is 8, or a pharmaceutically acceptable salt or ester thereof, for use as a procoagulant in a subject.
A bracket to hold a radiator with a minimum of one plate element that features webs and web dells located between two webs and, whereby, the radiator can be designed with or without convector plates, with a stand part shaped like a tube which can be installed in a hollow in the radiator, whereby, the stand part features a minimum of one aperture, at least in sectors, with a swivelling vane that is preferably arranged on a retaining device that can be adjustable in relation to the stand part, whereby, the vane has two conditions, namely, an initial condition (30.1), in which it can be moved in and out of the radiator, together with the stand part and an assembly condition (30.2), in which it has a clamping surface with which it is clamped in the radiator by utilization of the contact surface, characterized in that, the stand part features a contact surface that can be attached to the radiator of the system, that is only provided as a single vane on the stand part and that the vane in the initial condition (30.1) can be swivelled through or arranged in the aperture in the stand part.
A method by a mobile station, said method comprising: transmitting to a base station a preamble; said method being characterized in that: when an Acquisition Indicator, AI, received from the base station in response to said preamble is a negative acknowledgement and no dedicated resource allocation information is received from the base station within a predetermined period of time since the transmission of the preamble, checking a retransmission counter and, unless the retransmission counter shows 0, retransmitting the preamble to the base station after a lapse of time and decrementing the retransmission counter by one, or otherwise, terminating the transmission; and when the AI received from the base station in response to said preamble is a negative acknowledgement and dedicated resource allocation information is received from the base station within a predetermined period of time since the transmission of the preamble, transmitting data to the base station using a resource indicated by the dedicated resource allocation information. when an Acquisition Indicator, AI, received from the base station in response to said preamble is a negative acknowledgement and no dedicated resource allocation information is received from the base station within a predetermined period of time since the transmission of the preamble, checking a retransmission counter and, unless the retransmission counter shows 0, retransmitting the preamble to the base station after a lapse of time and decrementing the retransmission counter by one, or otherwise, terminating the transmission; and when the AI received from the base station in response to said preamble is a negative acknowledgement and dedicated resource allocation information is received from the base station within a predetermined period of time since the transmission of the preamble, transmitting data to the base station using a resource indicated by the dedicated resource allocation information.
A method for making a cement composition for orthopedic or dental applications comprising: mixing a powder component with a liquid component and a metal to form a gaseous solution, wherein the metal comprises magnesium and reacts with water in the liquid component to produce hydrogen gas bubbles in the gaseous solution; and allowing the gaseous solution to set into a hardened porous mass, wherein the hydrogen gas bubbles create pores in the hardened mass; wherein the liquid component comprises silica; and wherein the powder component is a post-microwaved powder prepared by mixing a powder with a setting solution to form a paste, and irradiating the paste with microwaves to form the post-microwaved powder. mixing a powder component with a liquid component and a metal to form a gaseous solution, wherein the metal comprises magnesium and reacts with water in the liquid component to produce hydrogen gas bubbles in the gaseous solution; and allowing the gaseous solution to set into a hardened porous mass, wherein the hydrogen gas bubbles create pores in the hardened mass; wherein the liquid component comprises silica; and wherein the powder component is a post-microwaved powder prepared by mixing a powder with a setting solution to form a paste, and irradiating the paste with microwaves to form the post-microwaved powder.
A device for clamping a tool or a workpiece, the device comprising: a mounting portion fastenable to a spindle of a machine tool; a clamping portion extending from the mounting portion, the clamping portion and the mounting portion defining a bore extending therethrough; a collet attached via the device to a spindle nose of the machine tool, a guide bushing located within a portion of the bore defined by the clamping portion, and a plurality of differential screws positioned circumferentially around the clamping portion in communication with the guide bushing; wherein the collet is drawn into the bore of the clamping portion and clamped therein, characterised in that a sleeve is located at least partially in the guide bushing and in the bore, and is configured to receive the collet, and in that the plurality of differential screws are positioned equidistant circumferentially around the clamping portion. a mounting portion fastenable to a spindle of a machine tool; a clamping portion extending from the mounting portion, the clamping portion and the mounting portion defining a bore extending therethrough; a collet attached via the device to a spindle nose of the machine tool, a guide bushing located within a portion of the bore defined by the clamping portion, and a plurality of differential screws positioned circumferentially around the clamping portion in communication with the guide bushing; wherein the collet is drawn into the bore of the clamping portion and clamped therein,