Microtome for sectioning specimens of biological material, comprising a blade-holder device on which a cutting blade is supported, a cassette-holder device for supporting a cassette containing a block for the embedding of a specimen of biological material and means (6, 9, 20, 21, 22, 23, 24) for adjusting at least one cutting parameter (d, α, τ, v, Ω, r, w), further comprising means for acquiring an identification code associated with said cassette and means for associating to said identification code of said cassette at least one value of at least one cutting parameter adapted for the sectioning of said at least one specimen of biological material, the microtome being configured such that said at least one value of at least one cutting parameter (d, α, τ, v, Ω, r, w) adapted for the sectioning of said specimen of biological material is associated with said identification code in a roughing procedure of said specimen of biological material, or in a first sectioning procedure of said specimen of biological material and is used in a successive sectioning procedure of a plurality of sections of the specimen of biological material, wherein the microtome is configured in such a way that the cassette is removed from the cassette-holder device after a roughing procedure, or a first sectioning procedure of said specimen of biological material have been carried out and then reinserted in the cassette holder device for a successive sectioning procedure, wherein said adjusting means (6, 9, 20, 21, 22, 23, 24) are connected to a control unit so that said adjusting means (6, 9, 20, 21, 22, 23, 24) of at least one cutting parameter (d, α, τ, v, Ω, r, w) are configured to be automatically set again during the successive sectioning procedure depending on the at least one value of at least one cutting parameter adapted for the sectioning associated with said identification code during the roughing procedure, or during the first sectioning procedure, wherein said at least one value of at least one cutting parameter (d, α, τ, v, Ω, r, w) adapted for the sectioning corresponds to the value set, or attained, by the adjusting means (6, 9, 20, 21, 22, 23, 24) of at least one cutting parameter (d, α, τ, v, Ω, r, w) at the end of the roughing procedure, or at the end of said first sectioning procedure, wherein said at least one value of at least one cutting parameter (d, α, τ, v, Ω, r, w) adapted for the sectioning comprises the value of the distance (d) between said blade holder device and said cassette holder device used at the end of the roughing procedure, or at the end of a first sectioning procedure of said specimen of biological material. wherein the microtome is configured in such a way that the cassette is removed from the cassette-holder device after a roughing procedure, or a first sectioning procedure of said specimen of biological material have been carried out and then reinserted in the cassette holder device for a successive sectioning procedure, wherein said adjusting means (6, 9, 20, 21, 22, 23, 24) are connected to a control unit so that said adjusting means (6, 9, 20, 21, 22, 23, 24) of at least one cutting parameter (d, α, τ, v, Ω, r, w) are configured to be automatically set again during the successive sectioning procedure depending on the at least one value of at least one cutting parameter adapted for the sectioning associated with said identification code during the roughing procedure, or during the first sectioning procedure, wherein said at least one value of at least one cutting parameter (d, α, τ, v, Ω, r, w) adapted for the sectioning corresponds to the value set, or attained, by the adjusting means (6, 9, 20, 21, 22, 23, 24) of at least one cutting parameter (d, α, τ, v, Ω, r, w) at the end of the roughing procedure, or at the end of said first sectioning procedure, wherein said at least one value of at least one cutting parameter (d, α, τ, v, Ω, r, w) adapted for the sectioning comprises the value of the distance (d) between said blade holder device and said cassette holder device used at the end of the roughing procedure, or at the end of a first sectioning procedure of said specimen of biological material.