A neuromodulation/evaluation system, comprising: a neuromodulation catheter comprising an elongated shaft defining a lumen therethrough, a proximal portion, and a distal portion, wherein the distal portion is configured to deliver therapeutic neuromodulation at a target site in a renal blood vessel of a human patient; a guidewire configured to be slidably positioned within the lumen of the elongated shaft, the guidewire having a distal portion and a sensing element positioned along the distal portion, wherein the sensing element is configured to detect physiological measurements at the target site; and a controller configured to be communicatively coupled to the sensing element, wherein the controller is further configured to obtain the physiological measurements via the sensing element; determine a physiological parameter based on the physiological measurements, wherein the physiological parameter is renal wave speed, and wherein the sensing element is configured to take measurements used to determine renal wave speed; compare the physiological parameter to a predetermined threshold; and based on the comparison, provide an indication to an operator regarding whether the patient has physiological characteristics indicative of a therapeutic response to renal neuromodulation therapy at the target site, wherein the sensing element is configured to detect physiological measurements indicative of renal artery wave speed, and wherein the controller is configured to determine renal artery wave speed c based on the physiological measurements using the following equation: c = 1 ρ ∑ dP 2 ∑ dU 2 wherein P is pressure, U is velocity, and ρ is density of blood. a neuromodulation catheter comprising an elongated shaft defining a lumen therethrough, a proximal portion, and a distal portion, wherein the distal portion is configured to deliver therapeutic neuromodulation at a target site in a renal blood vessel of a human patient; a guidewire configured to be slidably positioned within the lumen of the elongated shaft, the guidewire having a distal portion and a sensing element positioned along the distal portion, wherein the sensing element is configured to detect physiological measurements at the target site; and a controller configured to be communicatively coupled to the sensing element, wherein the controller is further configured to obtain the physiological measurements via the sensing element; determine a physiological parameter based on the physiological measurements, wherein the physiological parameter is renal wave speed, and wherein the sensing element is configured to take measurements used to determine renal wave speed; compare the physiological parameter to a predetermined threshold; and based on the comparison, provide an indication to an operator regarding whether the patient has physiological characteristics indicative of a therapeutic response to renal neuromodulation therapy at the target site, wherein the sensing element is configured to detect physiological measurements indicative of renal artery wave speed, and wherein the controller is configured to determine renal artery wave speed c based on the physiological measurements using the following equation: c = 1 ρ ∑ dP 2 ∑ dU 2 wherein P is pressure, U is velocity, and ρ is density of blood. wherein the controller is further configured to obtain the physiological measurements via the sensing element; determine a physiological parameter based on the physiological measurements, wherein the physiological parameter is renal wave speed, and wherein the sensing element is configured to take measurements used to determine renal wave speed; compare the physiological parameter to a predetermined threshold; and based on the comparison, provide an indication to an operator regarding whether the patient has physiological characteristics indicative of a therapeutic response to renal neuromodulation therapy at the target site, wherein the sensing element is configured to detect physiological measurements indicative of renal artery wave speed, and wherein the controller is configured to determine renal artery wave speed c based on the physiological measurements using the following equation: c = 1 ρ ∑ dP 2 ∑ dU 2 wherein P is pressure, U is velocity, and ρ is density of blood.