A compound of Formula: wherein: R 1 is selected from the group consisting of hydrogen; R 2 is selected from the group consisting of hydrogen, C 2 -C 12 alkyl, substituted C 2 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 3 -C 12 cycloatkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxy, hydroxyalkyl, halo, haloalkyl, amino,-OR 3, -N(R 3)(R 4), -NR 3 C(=O)R 4, -NR 3 S(=O)PR 4,-NR 3 C(=O)NR 4 R 5, -NR 3 S(=O)PNR 4 R 5, -C(=O)R 4, -S(=O) p R 4, -C(=O)NR 3 R 4,- S(=O) p NR 3 R 4 and -C(=O)OR 4; R 3, R 4 and R 5 are each independently selected from the group consisting of hydrogen, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxy, hydroxyalkyl, halo and haloalkyl; R 6 is selected from the group consisting of hydrogen, halogen, hydroxy, -O-C 1 - 3 alkyl, C 1-3 haloalkyl, -O-C 1-3 haloalkyl, C 1-3 perhaloalkyl, -O-C 1-3 perhaloakyl, C 1-3 hydroxyakyl, -O-C 1-3 hydroxyalkyl, CN, -(CH 2) q C(=O)R 7, -O-(CH 2) q C(=O)R 7,-(CH 2) q N(R 8)(R 9), -S-C 1-3 alkyl, -S(=O) 2 -R 10 and -S(=O) 2 N(R 8)(R 9); q is 0, 1, 2 or 3; R 7 is selected from hydrogen, hydroxy, C 1-3 alkyl or C 1-3 alkoxy; and R 8, R 9 and R 10 are each independently hydrogen or C 1-3 alkyl; provided that R 1, R 2 and R 6 are not simultaneously hydrogen; and if R 1 and R 6 are both H, R 2 is not butyl; or a pharmaceutically acceptable salt thereof; a tautomer thereof; or a pharmaceutically acceptable salt of the tautomer; and wherein: substituted refers to the replacement of one or more hydrogen atoms with a monovalent or divalent radical selected from hydroxy, nitro, amino, imino, cyano, halo, thio, thioamido, amidino, imidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, alkyl, heterocyclyl, haloalkyl, alkoxy, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkylthio, aminoalkyl, and alkylamino, cyanoalkyl. R 1 is selected from the group consisting of hydrogen; R 2 is selected from the group consisting of hydrogen, C 2 -C 12 alkyl, substituted C 2 -C 12 alkyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 3 -C 12 cycloatkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxy, hydroxyalkyl, halo, haloalkyl, amino,-OR 3, -N(R 3)(R 4), -NR 3 C(=O)R 4, -NR 3 S(=O)PR 4,-NR 3 C(=O)NR 4 R 5, -NR 3 S(=O)PNR 4 R 5, -C(=O)R 4, -S(=O) p R 4, -C(=O)NR 3 R 4,- S(=O) p NR 3 R 4 and -C(=O)OR 4; R 3, R 4 and R 5 are each independently selected from the group consisting of hydrogen, C 1 -C 12 alkyl, substituted C 1 -C 12 alkyl, C 2 -C 12 alkynyl, substituted C 2 -C 12 alkynyl, C 2 -C 12 alkenyl, substituted C 2 -C 12 alkenyl, C 3 -C 12 cycloalkyl, substituted C 3 -C 12 cycloalkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heteroaryl, substituted heteroaryl, hydroxy, hydroxyalkyl, halo and haloalkyl; R 6 is selected from the group consisting of hydrogen, halogen, hydroxy, -O-C 1 - 3 alkyl, C 1-3 haloalkyl, -O-C 1-3 haloalkyl, C 1-3 perhaloalkyl, -O-C 1-3 perhaloakyl, C 1-3 hydroxyakyl, -O-C 1-3 hydroxyalkyl, CN, -(CH 2) q C(=O)R 7, -O-(CH 2) q C(=O)R 7,-(CH 2) q N(R 8)(R 9), -S-C 1-3 alkyl, -S(=O) 2 -R 10 and -S(=O) 2 N(R 8)(R 9); q is 0, 1, 2 or 3; R 7 is selected from hydrogen, hydroxy, C 1-3 alkyl or C 1-3 alkoxy; and R 8, R 9 and R 10 are each independently hydrogen or C 1-3 alkyl; provided that R 1, R 2 and R 6 are not simultaneously hydrogen; and if R 1 and R 6 are both H, R 2 is not butyl; or a pharmaceutically acceptable salt thereof; a tautomer thereof; or a pharmaceutically acceptable salt of the tautomer; and wherein: substituted refers to the replacement of one or more hydrogen atoms with a monovalent or divalent radical selected from hydroxy, nitro, amino, imino, cyano, halo, thio, thioamido, amidino, imidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, alkyl, heterocyclyl, haloalkyl, alkoxy, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkylthio, aminoalkyl, and alkylamino, cyanoalkyl. substituted refers to the replacement of one or more hydrogen atoms with a monovalent or divalent radical selected from hydroxy, nitro, amino, imino, cyano, halo, thio, thioamido, amidino, imidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, alkyl, heterocyclyl, haloalkyl, alkoxy, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkylthio, aminoalkyl, and alkylamino, cyanoalkyl.