mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula: wherein, Y is C-F, C-H or N; R 1 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, or HC NH-; R 2 is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkylC 1 -C 2 alkyl (wherein the cycloalkyl groups are optionally substituted with 1 to 3 groups represented by R 3), phenyl, phenylC 1 -C 2 alkyl (wherein the phenyl rings are optionally substituted with 1 to 3 groups represented by R 3), heteroaryl, heteroarylC 1 -C 2 alkyl, wherein the heteroaryl is a 5- or 6-membered aromatic monocyclic ring comprising 1, 2, 3 or 4 heteroatoms individually selected from nitrogen, oxygen and sulfur, heterocyclyl, heterocyclylC 1 -C 2 alkyl, wherein the heterocyclyl is a 4-, 5- or 6-membered non-aromatic monocyclic ring comprising 1, 2 or 3 heteroatoms individually selected from nitrogen, oxygen and sulfur, or a 5- to 12-membered non-aromatic annulated or spirocyclic carbobi- or carbotri-cyclyl ring system optionally comprising 1, 2, 3, 4 or 5 heteroatoms individually selected from nitrogen, oxygen and sulfur, and wherein the spirocyclic carbobi- or carbotri-cyclyl ring systems are each optionally bonded to the rest of the molecule through a C 1 -C 2 alkylene linker; R 3 is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 3 -C 8 cycloalkyl or C 3 -C 8 cycloalkylC 1 -C2alkyl; X is N or C-H; or a salt or an N-oxide thereof. Y is C-F, C-H or N; R 1 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, or HC NH-; R 2 is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkylC 1 -C 2 alkyl (wherein the cycloalkyl groups are optionally substituted with 1 to 3 groups represented by R 3), phenyl, phenylC 1 -C 2 alkyl (wherein the phenyl rings are optionally substituted with 1 to 3 groups represented by R 3), heteroaryl, heteroarylC 1 -C 2 alkyl, wherein the heteroaryl is a 5- or 6-membered aromatic monocyclic ring comprising 1, 2, 3 or 4 heteroatoms individually selected from nitrogen, oxygen and sulfur, heterocyclyl, heterocyclylC 1 -C 2 alkyl, wherein the heterocyclyl is a 4-, 5- or 6-membered non-aromatic monocyclic ring comprising 1, 2 or 3 heteroatoms individually selected from nitrogen, oxygen and sulfur, or a 5- to 12-membered non-aromatic annulated or spirocyclic carbobi- or carbotri-cyclyl ring system optionally comprising 1, 2, 3, 4 or 5 heteroatoms individually selected from nitrogen, oxygen and sulfur, and wherein the spirocyclic carbobi- or carbotri-cyclyl ring systems are each optionally bonded to the rest of the molecule through a C 1 -C 2 alkylene linker; R 3 is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 3 -C 8 cycloalkyl or C 3 -C 8 cycloalkylC 1 -C2alkyl; X is N or C-H; or a salt or an N-oxide thereof.
A plurality of vehicle control devices, each vehicle control device comprising: a verification section containing a start-up program (30, 32), an integrity verification program, a higher-importance region key, and a verification signature of a program within a higher-importance region, a lower-importance region key, and a verification signature of a program within a lower-importance region: wherein the start-up program (30, 32) is configured to verify the integrity of the program within the higher-importance region using the higher-importance region key, and the verification signature of the program within a higher-importance region and start up the program, wherein the program within the higher-importance region is related to vehicle travel or safety; and the start-up program (30, 32) is further configured to verify the integrity of the program within the lower-importance region using the lower-importance region key, and the verification signature of the program within a lower-importance region after the program within the higher-importance region has been started up by the start-up program (30, 32), wherein the program within the lower-importance region is not related to vehicle travel or safety; characterised in that the higher-importance region key is a different key for each vehicle control device of the plurality of vehicle control devices; and the lower-importance region key is an identical key for each vehicle control device of the plurality of vehicle control devices of the same type. a verification section containing a start-up program (30, 32), an integrity verification program, a higher-importance region key, and a verification signature of a program within a higher-importance region, a lower-importance region key, and a verification signature of a program within a lower-importance region: wherein the start-up program (30, 32) is configured to verify the integrity of the program within the higher-importance region using the higher-importance region key, and the verification signature of the program within a higher-importance region and start up the program, wherein the program within the higher-importance region is related to vehicle travel or safety; and the start-up program (30, 32) is further configured to verify the integrity of the program within the lower-importance region using the lower-importance region key, and the verification signature of the program within a lower-importance region after the program within the higher-importance region has been started up by the start-up program (30, 32), wherein the program within the lower-importance region is not related to vehicle travel or safety; characterised in that the higher-importance region key is a different key for each vehicle control device of the plurality of vehicle control devices; and the lower-importance region key is an identical key for each vehicle control device of the plurality of vehicle control devices of the same type.
A gas-generating pyrotechnic solid object, the composition of which, expressed as weight percentages, contains: - from 35 to 50%, advantageously from 40 to 50%, of guanidine nitrate, - from 35 to 50% of basic copper nitrate, - from 0.5 to 6% of at least one compound chosen from alumina and inorganic titanates, the melting point of which is above 2100 K, and - from 5 to 18%, advantageously from 5 to 13%, of at least one inorganic oxalate chosen from sodium oxalate, tin oxalate, strontium oxalate, iron oxalate, copper oxalate and mixtures thereof; said composition being free of binder and of explosive ingredient. - from 35 to 50%, advantageously from 40 to 50%, of guanidine nitrate, - from 35 to 50% of basic copper nitrate, - from 0.5 to 6% of at least one compound chosen from alumina and inorganic titanates, the melting point of which is above 2100 K, and - from 5 to 18%, advantageously from 5 to 13%, of at least one inorganic oxalate chosen from sodium oxalate, tin oxalate, strontium oxalate, iron oxalate, copper oxalate and mixtures thereof;
A self-inflating tire comprising a tire cavity; first and second sidewalls (30, 32) extending respectively from first and second tire bead regions (34, 36) to a tire tread region; a first and a second air tube connected to the tire, wherein each air tube defines an air passageway; and an air passageway operative to allow a portion of the air passageway near a tire footprint to substantially open and close the air passageway; an inlet regulator device mounted in the tire and comprising a regulator body, the regulator body having an internal chamber and an outer duct having a distal end located within the tire cavity, wherein the duct has an internal bore therethrough in fluid communication with the tire cavity and said internal chamber, wherein the inlet regulator device is connected to an inlet end of the air passageway; wherein a pressure membrane is mounted within the internal chamber of the regulator body; wherein the pressure membrane has a first side in fluid communication with the tire cavity and a second side in fluid communication with an outside air pressure; wherein the inlet regulator device further includes two opposed passageways in the regulator body that are connected to an inlet end of the first and second air tubes, and wherein the inlet regulator device comprises an insert at least partially mounted within the internal chamber of the regulator body, the insert having a flanged end that surrounds an internal cavity or having a portion, wherein the flanged end or the portion is engageable with the pressure membrane; and wherein the pressure membrane is responsive to a cavity tire pressure and an outside air pressure and wherein the pressure membrane is positioned for engagement with the distal end of the regulator body when the tire pressure reaches a set value for opening and closing the inlet regulator device to allow or prevent air flow from entering the inlet regulator device.
A composition for use in a method of treating, or reducing risk of, obesity or a disorder associated with obesity, or improving glycemic control, in a mammalian subject, the method comprising administering a therapeutically effective amount of said composition, wherein the composition comprises a Chromosome 20 Open Reading Frame 27 (C20orf27) polypeptide or a nucleic acid encoding a C20orf27 polypeptide, to a subject in need thereof.
A method for making magnolol (5,5'-diallyl-biphenyl-2,2'-diol) or tetrahydromagnolol (5,5'-dipropyl-biphenyl-2,2'-diol), comprising i) methylating biphenyl-2,2'-diol using dimethyl sulfate, to obtain 2,2'-dimethoxy-biphenyl; ii) brominating the 2,2'-dimethoxy-biphenyl to obtain 2,2'-dimethoxy-5,5'-dibromo-biphenyl; iii) alkylating the 2,2'-dimethoxy-5,5'-dibromo-biphenyl with allyl bromide to obtain 2,2'-dimethoxy-5,5'-diallyl-biphenyl; iv) demethylating the 2,2'-dimethoxy-5,5'-diallyl-biphenyl by reaction with aluminium chloride and thiourea; v) recovering the 5,5'-diallyl-biphenyl-2,2'-diol thus obtained; and vi) optionally hydrogenating the 5,5'-diallyl-biphenyl-2,2'-diol in the presence of a metal catalyst and recovering the 5,5'-dipropyl-biphenyl-2,2'-diol thus obtained. i) methylating biphenyl-2,2'-diol using dimethyl sulfate, to obtain 2,2'-dimethoxy-biphenyl; ii) brominating the 2,2'-dimethoxy-biphenyl to obtain 2,2'-dimethoxy-5,5'-dibromo-biphenyl; iii) alkylating the 2,2'-dimethoxy-5,5'-dibromo-biphenyl with allyl bromide to obtain 2,2'-dimethoxy-5,5'-diallyl-biphenyl; iv) demethylating the 2,2'-dimethoxy-5,5'-diallyl-biphenyl by reaction with aluminium chloride and thiourea; v) recovering the 5,5'-diallyl-biphenyl-2,2'-diol thus obtained; and vi) optionally hydrogenating the 5,5'-diallyl-biphenyl-2,2'-diol in the presence of a metal catalyst and recovering the 5,5'-dipropyl-biphenyl-2,2'-diol thus obtained.
A system operatively connected to a waveform generator linked to a patient-implantable electrode suitable for use in a method for reversibly blocking an action potential in a nerve of a patient to effect pain relief in the patient, the waveform generator having an electrode connector which is connected with the electrode, characterized by the electrode comprising strips of conductive material in a sandwich configuration with two opposing sheets of a non-conductive, self-curling material, wherein one surface of the non-conductive material comprises apertures at periodic intervals forming an implantable expandable spiral cuff and the waveform generator is configured to provide a waveform at one of a voltage ranging from 4 Vpp to 20 Vpp, or a current ranging from 4 mApp to 26 mApp for an interval sufficient to effect substantially immediate pain relief in a patient.
Micro or nanosystems constituted of an inorganic oxide-based matrix with regular porosity controlled through the use of a generic surfactant or through the use of a mechanism of molecular imprinting, said micro or nanosystems being suitable for active targeting of molecules, atoms or ions with biological activity and being aimed at the local release in biological compartments of therapeutic interest, characterized in that the pores contain a biologically active substance, that a substance devoted to targeting and molecular recognition selected from folic acid, a peptide, an antibody, a glycoside, a carbohydrate or a protein is selectively coupled onto the external surface of said micro or nanosystem, and that the substance selectively coupled onto the external surface is not the biologically active substance contained within the pores.
Process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment; b) optionally, washing; c) enzymatic hydrolysis; d) fermentation; and e) optionally, recovery of a fermentation product; wherein in step (c) an enzyme composition is used that has a temperature optimum of 60°C or higher, the hydrolysis time is 40 hours or more, the hydrolysis temperature is 60°C or more and wherein the dry matter content in the hydrolysis step (c) is 14% w/dry matter weight or more and wherein in step (d) the fermentation is conducted with a microorganism that is able to ferment at least one C5 sugar. a) optionally, pretreatment; b) optionally, washing; c) enzymatic hydrolysis; d) fermentation; and e) optionally, recovery of a fermentation product; wherein in step (c) an enzyme composition is used that has a temperature optimum of 60°C or higher, the hydrolysis time is 40 hours or more, the hydrolysis temperature is 60°C or more and wherein the dry matter content in the hydrolysis step (c) is 14% w/dry matter weight or more and wherein in step (d) the fermentation is conducted with a microorganism that is able to ferment at least one C5 sugar.
A method for controlling traffic between a mobile communication terminal and a plurality of hosts (15, 15a-c), the method being performed in a TCP, Transport Control Protocol, proxy of a cellular network, the TCP proxy comprising a radio side towards the mobile communication terminal, and a network side towards the plurality of hosts, the method comprising the steps of: obtaining a communication distance indicator for each TCP connection between the TCP proxy and each one of the hosts (15, 15a-c), wherein the communication distance indicator indicates a time it takes to communicate between a respective host of the plurality of hosts (15, 15a-c) and the TCP proxy; detecting a constrained traffic situation on the radio side for traffic towards the mobile communication terminal; and reducing incoming traffic on the network side based on the respective communication distance indicators, wherein the incoming traffic is reduced more for a TCP connection with a large communication distance indicator compared to a TCP connection with a small communication distance indicator. obtaining a communication distance indicator for each TCP connection between the TCP proxy and each one of the hosts (15, 15a-c), wherein the communication distance indicator indicates a time it takes to communicate between a respective host of the plurality of hosts (15, 15a-c) and the TCP proxy; detecting a constrained traffic situation on the radio side for traffic towards the mobile communication terminal; and reducing incoming traffic on the network side based on the respective communication distance indicators, wherein the incoming traffic is reduced more for a TCP connection with a large communication distance indicator compared to a TCP connection with a small communication distance indicator.
A composition for seed treatment comprising a plant seed binding protein, wherein said plant seed binding protein is an antigen binding protein, wherein said antigen binding protein comprises a VHH sequence, wherein said VHH binds pectin comprising low esterified homogalacturonan, wherein said plant seed binding protein is capable of binding a plant enhancing agent to the plant seed.
A straddled vehicle comprising: a frame; a storage box including an annular opening end that defines an opening opened upward; a seat arranged over the opening of the storage box; a hinge including a movable bracket that is a separate member from the seat, the movable bracket being attached to the seat, the movable bracket being rotatable together with the seat with respect to the frame between a closed position where the opening of the storage box is closed with the seat and an open position where the opening of the storage box is opened, the movable bracket being configured to overlap the opening of the storage box in a plan view of the straddled vehicle when the seat is arranged in the closed position; an annular first sealing member configured to be sandwiched between the seat and the storage box to seal a clearance gap between the seat and the storage box when the seat is arranged in the closed position; characterized by a second sealing member sandwiched between the seat and the movable bracket to seal a clearance gap between the seat and the movable bracket. a frame; a storage box including an annular opening end that defines an opening opened upward; a seat arranged over the opening of the storage box; a hinge including a movable bracket that is a separate member from the seat, the movable bracket being attached to the seat, the movable bracket being rotatable together with the seat with respect to the frame between a closed position where the opening of the storage box is closed with the seat and an open position where the opening of the storage box is opened, the movable bracket being configured to overlap the opening of the storage box in a plan view of the straddled vehicle when the seat is arranged in the closed position; an annular first sealing member configured to be sandwiched between the seat and the storage box to seal a clearance gap between the seat and the storage box when the seat is arranged in the closed position; characterized by a second sealing member sandwiched between the seat and the movable bracket to seal a clearance gap between the seat and the movable bracket.
A cleaning composition comprising: at least two anionic surfactants, wherein the at least two anionic surfactants comprise a linear alkylbenzene sulfonate and a sodium lauryl ether sulfate (SLES), wherein the LAS and the SLES are present in the cleaning composition in a total amount combined of 1%-2% by weight and wherein a weight ratio of LAS:SLES is 3:1 to 1:1 or 6:1 to 4:1; an ionic agent in an amount of 0.01% to 0.125% by weight; a nonionic surfactant in an amount of at least 0.45% by weight, and a fragrance, wherein the ionic agent is selected from metal chlorides, hydroxides, phosphates, iminodisuccinates and citrates. at least two anionic surfactants, wherein the at least two anionic surfactants comprise a linear alkylbenzene sulfonate and a sodium lauryl ether sulfate (SLES), wherein the LAS and the SLES are present in the cleaning composition in a total amount combined of 1%-2% by weight and wherein a weight ratio of LAS:SLES is 3:1 to 1:1 or 6:1 to 4:1; an ionic agent in an amount of 0.01% to 0.125% by weight; a nonionic surfactant in an amount of at least 0.45% by weight, and a fragrance, wherein the ionic agent is selected from metal chlorides, hydroxides, phosphates, iminodisuccinates and citrates.
An esterase which (i) has at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identity to the full length amino acid sequence set forth in SEQ ID N°1, (ii) contains at least the combination of substitutions N207C + S256C, and (iii) has an increased polyester degrading activity and/or an increased thermostability as compared to the esterase of SEQ ID N°1.
A rotational intravascular ultrasound (IVUS) device, comprising: a flexible elongate member; an elongate housing coupled to a distal portion of the flexible elongate member, the elongate housing defining a circular outer profile; a piezoelectric micromachined ultrasound transducer (PMUT) mounted within the elongate housing at an oblique angle with respect to a central longitudinal axis of the elongate housing such that the PMUT is configured to facilitate Doppler ultrasound velocity measurements of blood flow through a vessel in which the IVUS device is positioned, wherein the PMUT is formed on a microelectromechanical system (MEMS) component sized and shaped such that the MEMS component does not extend beyond the circular outer profile of the elongate housing; and an application-specific integrated circuit (ASIC) electrically coupled to the PMUT adjacent to the distal portion of the flexible elongate member. a flexible elongate member; an elongate housing coupled to a distal portion of the flexible elongate member, the elongate housing defining a circular outer profile; a piezoelectric micromachined ultrasound transducer (PMUT) mounted within the elongate housing at an oblique angle with respect to a central longitudinal axis of the elongate housing such that the PMUT is configured to facilitate Doppler ultrasound velocity measurements of blood flow through a vessel in which the IVUS device is positioned, wherein the PMUT is formed on a microelectromechanical system (MEMS) component sized and shaped such that the MEMS component does not extend beyond the circular outer profile of the elongate housing; and an application-specific integrated circuit (ASIC) electrically coupled to the PMUT adjacent to the distal portion of the flexible elongate member.
A compound selected from the group consisting of: or a pharmaceutically acceptable salt or ester thereof; and a DPP IV inhibitor, for use in a method of (i) treating diabetes, (ii) lowering blood levels of glucose, (iii) lowering blood levels of insulin, (iv) increasing blood levels of incretins, (v) lowering blood levels of triglycerides, or (vi) increasing glucose dependent insulin production. (i) treating diabetes, (ii) lowering blood levels of glucose, (iii) lowering blood levels of insulin, (iv) increasing blood levels of incretins, (v) lowering blood levels of triglycerides, or (vi) increasing glucose dependent insulin production.