A compound of Formula: or a pharmaceutical salt thereof, wherein: R 1 is selected from a group consisting of H, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are optionally substituted with one to five R 1a; R 1a is selected from a group consisting of H, deuterium, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are optionally substituted with halogen, cyano, OR a, SR a, NR b R c, alkyl, alkenyl, alkynyl, cycloalkyl, or heterocycloalkyl; R 2 is selected from a group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein R 2 is optionally substituted with one to five R 2a; R 2a is selected from a group consisting of H, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R C, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, and alkynyl; R 3 is selected from a group consisting of H, deuterium, alkyl, alkenyl, alkynyl, deuterated alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, cycloalkyl, and cycloalkylalkyl; R 4 is selected from a group consisting of H, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, and cycloalkylalkyl; R 5 is selected from a group consisting of H, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are substituted with one to three R 5a; R 5a is selected from a group consisting of H, deuterium, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R c, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; R 6 and R 7 are each selected from a group consisting of H, amino, and alkyl; R a, R b, R c, and R d are independently selected from a group consisting of H, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; or R b and R c, together with nitrogen atom(s) to which they are attached, form a four- to seven-membered heterocycloalkyl, and optionally substituted with one to three R e; and R e is selected from a group consisting of H, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R c, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and wherein, any hydrogen atom in the compound of Formula may be deuterium. R 1 is selected from a group consisting of H, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are optionally substituted with one to five R 1a; R 1a is selected from a group consisting of H, deuterium, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are optionally substituted with halogen, cyano, OR a, SR a, NR b R c, alkyl, alkenyl, alkynyl, cycloalkyl, or heterocycloalkyl; R 2 is selected from a group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein R 2 is optionally substituted with one to five R 2a; R 2a is selected from a group consisting of H, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R C, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, and alkynyl; R 3 is selected from a group consisting of H, deuterium, alkyl, alkenyl, alkynyl, deuterated alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, cycloalkyl, and cycloalkylalkyl; R 4 is selected from a group consisting of H, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, and cycloalkylalkyl; R 5 is selected from a group consisting of H, halogen, cyano, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, wherein alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl are substituted with one to three R 5a; R 5a is selected from a group consisting of H, deuterium, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R c, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; R 6 and R 7 are each selected from a group consisting of H, amino, and alkyl; R a, R b, R c, and R d are independently selected from a group consisting of H, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; or R b and R c, together with nitrogen atom(s) to which they are attached, form a four- to seven-membered heterocycloalkyl, and optionally substituted with one to three R e; and R e is selected from a group consisting of H, halogen, cyano, OR a, SR a, NR b R c, NR b C R d, NR b C OR d, NR b C NR b R c, NR b S 2 R d, NR b S 2 NR b R c, C NR b R c, C OR d, S 2 NR b R c, C R d, S 2 R d, P R b R c, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and wherein, any hydrogen atom in the compound of Formula may be deuterium.