A first imaging agent having the structure: wherein J is O; Q is halo or haloalkyl; n is 0, 1, 2, or 3; R 21, R 22 and R 27 are independently selected from hydrogen, C 1 -C 6 alkyl optionally substituted with an imaging moiety, and an imaging moiety; R 23, R 24, R 25, and R 26 are independently selected from hydrogen, halogen, hydroxyl, alkyloxy, C 1 -C 6 alkyl optionally substituted with an imaging moiety, and an imaging moiety; R 29 is C 1 -C 6 alkyl optionally substituted with an imaging moiety; Y is carbon; K and L are hydrogen; and M is selected from the group consisting of alkoxyalkyl optionally substituted with an imaging moiety, alkyloxy optionally substituted with an imaging moiety, aryl optionally substituted with an imaging moiety, C 1 -C 6 alkyl optionally substituted an imaging moiety, heteroaryl optionally substituted with an imaging moiety, and an imaging moiety; provided that at least one imaging moiety is present, or a salt thereof; or/and a second imaging agent having the structure: wherein R 9 and R 10 are independently selected from the group consisting of H, -OR 11, F, Cl, Br, I, -CF 3, alkyl(C 1 -C 4), and imaging moiety (I m); R 11, R 12 and R 13 are selected from the group consisting of H, alkyl, and aryl; and W and X are independently selected from the group consisting of H, -OR 4, -N(R 11) 2, F, Cl, Br, -CF 3, I m, aryl, and heteroaryl; wherein A) Y and Z are independently selected from the group consisting of -CH-, - CH 2 -, -O-, -N-, -NR 11 -, and -CH=CH- when a linking group Q between Y and Z is present or absent, wherein Q is selected from the group consisting of -CH-, -CH 2 -, -CR 11 -, -N-, -NH-, - NR 11 -, -O-, and -S-; or B) Y and Z are independently selected from the group consisting of H, -OR 4, - N(R 11) 2, F, Cl, Br, -CF 3, I m, aryl, and heteroaryl when linking group Q is absent; wherein I m is selected from the group consisting of 18 F, 76 Br, 124 I, and 131 I, and is present in either W-Z or R 9 -R 13; or a salt thereof, for use in a method of determining perfusion and innervation mismatch in a portion of a human subject, wherein said method comprises: administering to the subject a first imaging agent and acquiring at least one first image of a portion of the subject, wherein the first imaging agent is employed to image perfusion; administering to the subject a second imaging agent and acquiring at least one second image of the portion of the subject, wherein the second imaging agent is employed to image innervation; and determining regional mismatch of innervation and perfusion areas in the portion of the subject based at least in part on the at least one first image and the at least one second image. J is O; Q is halo or haloalkyl; n is 0, 1, 2, or 3; R 21, R 22 and R 27 are independently selected from hydrogen, C 1 -C 6 alkyl optionally substituted with an imaging moiety, and an imaging moiety; R 23, R 24, R 25, and R 26 are independently selected from hydrogen, halogen, hydroxyl, alkyloxy, C 1 -C 6 alkyl optionally substituted with an imaging moiety, and an imaging moiety; R 29 is C 1 -C 6 alkyl optionally substituted with an imaging moiety; R 9 and R 10 are independently selected from the group consisting of H, -OR 11, F, Cl, Br, I, -CF 3, alkyl(C 1 -C 4), and imaging moiety (I m); R 11, R 12 and R 13 are selected from the group consisting of H, alkyl, and aryl; and W and X are independently selected from the group consisting of H, -OR 4, -N(R 11) 2, F, Cl, Br, -CF 3, I m, aryl, and heteroaryl; wherein A) Y and Z are independently selected from the group consisting of -CH-, - CH 2 -, -O-, -N-, -NR 11 -, and -CH=CH- when a linking group Q between Y and Z is present or absent, wherein Q is selected from the group consisting of -CH-, -CH 2 -, -CR 11 -, -N-, -NH-, - NR 11 -, -O-, and -S-; or B) Y and Z are independently selected from the group consisting of H, -OR 4, - N(R 11) 2, F, Cl, Br, -CF 3, I m, aryl, and heteroaryl when linking group Q is absent; wherein I m is selected from the group consisting of 18 F, 76 Br, 124 I, and 131 I, and is present in either W-Z or R 9 -R 13; or a salt thereof, administering to the subject a first imaging agent and acquiring at least one first image of a portion of the subject, wherein the first imaging agent is employed to image perfusion; administering to the subject a second imaging agent and acquiring at least one second image of the portion of the subject, wherein the second imaging agent is employed to image innervation; and determining regional mismatch of innervation and perfusion areas in the portion of the subject based at least in part on the at least one first image and the at least one second image.