An imaging system for imaging individual wells of a microplate, the imaging system comprising: - a camera comprising magnification optics to establish a field of view encompassing a well when the well is positioned within the field of view of the camera; - a camera interface configured to provide control data to the camera to control the imaging by the camera, and to receive image data acquired by the camera; - a light source for illuminating the well; - a memory comprising instruction data representing a set of instructions; and - a processor configured to communicate with the camera interface and the memory and to execute the set of instructions, wherein the set of instructions, when executed by the processor, cause the processor to: - control the camera to acquire a series of images (200, 210) of the well with different exposures, the series of images comprising a base image with a base exposure and at least one further image with a larger exposure than the base exposure, and - merge the series of images into an output image which comprises in a center region of the well image content from the base image and at a peripheral region of the well image content from the at least one further image, wherein the merging comprises selecting a different set of frequency components from each of the series of images for inclusion in the output image, wherein the selecting the different set of frequency components comprises: - selecting at least lower frequency components from the base image; and - selecting higher frequency components, while omitting selecting the lower frequency components, from the further image. - a camera comprising magnification optics to establish a field of view encompassing a well when the well is positioned within the field of view of the camera; - a camera interface configured to provide control data to the camera to control the imaging by the camera, and to receive image data acquired by the camera; - a light source for illuminating the well; - a memory comprising instruction data representing a set of instructions; and - a processor configured to communicate with the camera interface and the memory and to execute the set of instructions, wherein the set of instructions, when executed by the processor, cause the processor to: - control the camera to acquire a series of images (200, 210) of the well with different exposures, the series of images comprising a base image with a base exposure and at least one further image with a larger exposure than the base exposure, and - merge the series of images into an output image which comprises in a center region of the well image content from the base image and at a peripheral region of the well image content from the at least one further image, wherein the merging comprises selecting a different set of frequency components from each of the series of images for inclusion in the output image, wherein the selecting the different set of frequency components comprises: - selecting at least lower frequency components from the base image; and - selecting higher frequency components, while omitting selecting the lower frequency components, from the further image. - control the camera to acquire a series of images (200, 210) of the well with different exposures, the series of images comprising a base image with a base exposure and at least one further image with a larger exposure than the base exposure, and - merge the series of images into an output image which comprises in a center region of the well image content from the base image and at a peripheral region of the well image content from the at least one further image, wherein the merging comprises selecting a different set of frequency components from each of the series of images for inclusion in the output image, wherein the selecting the different set of frequency components comprises: - selecting at least lower frequency components from the base image; and - selecting higher frequency components, while omitting selecting the lower frequency components, from the further image.