mhurhangee/ep-ind-claims huggingface dataset:
A production method of a difluoroacetic acid ester, comprising at least: a reaction step of obtaining a reaction liquid by reaction of an alcohol represented by ROH (where R is a C 1 -C 4 alkyl group) with difluoroacetic acid fluoride (CHF 2 COF) in the presence of an amide compound of the following formula or a sulfone compound of the following formula as a hydrogen fluoride trapping agent where A can be the same or different and each independently represents a C 1 -C 3 alkyl group; and B represents a hydrogen atom or a C 1 -C 3 alkyl group; where D can be the same or different and each independently represents a C 1 -C 3 alkyl group; and a distillation step of extracting a difluoroacetic acid ester represented by CHF 2 COOR (where R is the same as defined above) by distillation of the reaction liquid obtained in the first step. a reaction step of obtaining a reaction liquid by reaction of an alcohol represented by ROH (where R is a C 1 -C 4 alkyl group) with difluoroacetic acid fluoride (CHF 2 COF) in the presence of an amide compound of the following formula or a sulfone compound of the following formula as a hydrogen fluoride trapping agent where A can be the same or different and each independently represents a C 1 -C 3 alkyl group; and B represents a hydrogen atom or a C 1 -C 3 alkyl group; where D can be the same or different and each independently represents a C 1 -C 3 alkyl group; and a distillation step of extracting a difluoroacetic acid ester represented by CHF 2 COOR (where R is the same as defined above) by distillation of the reaction liquid obtained in the first step.
Coke oven operating machines, with a coke oven transfer machine and a coke oven pushing machine, which comprise a door tool, characterised in that the door tool is designed as a detachable module, such that it can be used as a replacement part for the coke oven transfer machine and the coke oven pushing machine, wherein the detachable module can be connected by a quick-action coupling to the coke oven transfer machine and the coke oven pushing machine and the coke oven transfer machine and the coke pushing machine comprise a chassis, wherein a door tool is arranged with a quick-action connection on the chassis and the quick-action connection comprises a positioning device and a locking device, so that it can be exchanged within the six hours required by the machine technology.
System with an electrical apparatus and a connecting device, wherein the electrical apparatus comprises a control unit, a first interface device and a second interface device, and wherein a wire-bound first communication path is provided between the control unit and the connecting device via the first interface device and a second communication path is provided between the control unit and the second interface device, and wherein the system has a coupling device, the coupling device can be set into a first coupling state and into a second coupling state, the first communication path is led through the coupling device in the first coupling state and is interrupted in the coupling device in the second coupling state, and the control unit is designed to detect an attack on the system via the second interface device and, in the event of a detected attack, to set the coupling device from the first coupling state into the second coupling state.
An optical lens obtained by molding a polycarbonate resin comprising a structural unit represented by general formula below: wherein R represents H, CH 3 or C 2 H 5.
A compound of Formula (Ip), or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof: wherein: R 1' is hydrogen; Z is CR Z; R Z is hydrogen, deuterium, halogen, or C 1 -C 6 alkyl; R 2 is hydrogen, deuterium, or C 1 -C 6 alkyl; R 3 is hydrogen, deuterium, or C 1 -C 6 alkyl; each R 4 is independently deuterium, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 deuteroalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 heteroalkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; or two R 4 on the same carbon are taken together to form an oxo; m is 0-2; R 5 is hydrogen, halogen, or C 1 -C 6 alkyl; R 6 is hydrogen, halogen, or C 1 -C 6 alkyl; R 7 is hydrogen, halogen, or C 1 -C 6 alkyl; R 8 is C 1 -C 6 alkyl or cycloalkyl, wherein the alkyl and cycloalkyl is optionally substituted with one or more R; and each R is independently halogen, -CN, -OH, -OC 1 -C 3 alkyl, -OC 1 -C 3 haloalkyl, -SC 1 -C 3 alkyl, -S(=O)C 1 -C 3 alkyl, -S(=O) 2 C 1 -C 3 alkyl, -S(=O) 2 NH 2, -S(=O) 2 NHC 1 -C 3 alkyl, -S(=O) 2 N(C 1 -C 3 alkyl) 2, -NH 2, -NHC 1 -C 3 alkyl, -N(C 1 -C 3 alkyl) 2, -C(=O)C 1 -C 3 alkyl, -C(=O)OH, -C(=O)OC 1 -C 3 alkyl, -C(=O)NH 2, -C(=O)NHC 1 -C 3 alkyl, -C(=O)N(C 1 -C 3 alkyl) 2, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 deuteroalkyl, C 1 -C 3 hydroxyalkyl, C 1 -C 3 aminoalkyl, C 1 -C 3 heteroalkyl, or C 3 -C 6 cycloalkyl; or two R on the same atom are taken together to form an oxo. R 1' is hydrogen; Z is CR Z; R Z is hydrogen, deuterium, halogen, or C 1 -C 6 alkyl; R 2 is hydrogen, deuterium, or C 1 -C 6 alkyl; R 3 is hydrogen, deuterium, or C 1 -C 6 alkyl; each R 4 is independently deuterium, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 deuteroalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 heteroalkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; or two R 4 on the same carbon are taken together to form an oxo; m is 0-2; R 5 is hydrogen, halogen, or C 1 -C 6 alkyl; R 6 is hydrogen, halogen, or C 1 -C 6 alkyl; R 7 is hydrogen, halogen, or C 1 -C 6 alkyl; R 8 is C 1 -C 6 alkyl or cycloalkyl, wherein the alkyl and cycloalkyl is optionally substituted with one or more R; and each R is independently halogen, -CN, -OH, -OC 1 -C 3 alkyl, -OC 1 -C 3 haloalkyl, -SC 1 -C 3 alkyl, -S(=O)C 1 -C 3 alkyl, -S(=O) 2 C 1 -C 3 alkyl, -S(=O) 2 NH 2, -S(=O) 2 NHC 1 -C 3 alkyl, -S(=O) 2 N(C 1 -C 3 alkyl) 2, -NH 2, -NHC 1 -C 3 alkyl, -N(C 1 -C 3 alkyl) 2, -C(=O)C 1 -C 3 alkyl, -C(=O)OH, -C(=O)OC 1 -C 3 alkyl, -C(=O)NH 2, -C(=O)NHC 1 -C 3 alkyl, -C(=O)N(C 1 -C 3 alkyl) 2, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 deuteroalkyl, C 1 -C 3 hydroxyalkyl, C 1 -C 3 aminoalkyl, C 1 -C 3 heteroalkyl, or C 3 -C 6 cycloalkyl; or two R on the same atom are taken together to form an oxo.
A pump stopper (E, F) configured to be inserted detachably to a dispenser including: an attachment cap that is fitted to a mouth tubular portion of a container main body and that has a top wall; a pump that is fitted to the attachment cap; and a nozzle head that is fitted to an upper end of the pump and that has a tubular body extending vertically downward, wherein the pump stopper (E, F) comprises a substantially cylindrical-shaped stopper main body provided with a side opening in a manner such that the stopper main body is C-shaped in an upper view thereof, and the stopper main body includes, on one of an upper end side and a lower end side thereof, a regulating portion that prevents the tubular body of the nozzle head from being displaced downward, and, on another one of the upper end side and the lower end side thereof, a space portion that allows the tubular body of the nozzle head to be displaced downward when the pump stopper (E, F) is inserted between the top wall of the attachment cap and the tubular body of the nozzle head, characterized in that the stopper main body further includes: an inner tubular wall, which is formed in a cylindrical shape a portion of which is cut away circumferentially along side end surfaces thereof; and an outer tubular wall, which is connected to an outer circumferential side of the inner tubular wall with a predetermined distance therebetween and which is formed in a cylindrical shape a portion of which is cut away circumferentially along side end surfaces thereof, and wherein the space portion is defined between the inner tubular wall and the outer tubular wall, and one of an upper end side and a lower end side of each of the inner tubular wall and the outer tubular wall is connected each other as the regulating portion.
Alignment tool for mounting a flexible tube between a first pipe end and a second pipe end, where the alignment tool is adapted to be used to align the first pipe end to the second pipe end, characterized in that the alignment tool is provided with a single semi-circular body having a diameter corresponding to the diameter of the flexible tube, where the length of the alignment tool corresponds to the length of the flexible tube, and that the alignment tool is adapted to bear on the flexible tube during the mounting of the flexible tube between the first pipe end and the second pipe end.
A method of making a bioengineered tissue graft, comprising combining functional subunits, wherein the first functional subunits are obtained by microencapsulating pluripotent or multipotent cells and treating them to induce osteogenic differentiation, and wherein the second functional subunits are obtained by microencapsulating pluripotent or multipotent cells and treating them to induce chondrogenic differentiation, and wherein the first and second functional subunits are separated by undifferentiated microencapsulated pluripotent or multipotent cells; and culturing the combined functional subunits to form a bioengineered tissue graft that mimics the structural and functional characteristics of an osteochondral tissue.
Device (10; 300; 400; 500; 600; 700) for adjusting an actuator (344; 444; 544; 644; 744), in particular a clutch actuator of a vehicle, comprising a first valve means (14, 16; 314, 316; 414, 416; 514, 516; 614, 616; 714, 714), via which pressure can be applied on said actuator, and comprising a second valve means (24; 124; 324; 414; 524; 624; 724) via which the pressure on said actuator can be relieved, wherein said first valve means includes a first and a second solenoid valve, which are connected in parallel, with said first solenoid valve (14; 314; 414; 514; 614; 714) presenting a first flow area for the passage of a first volume flow and said second solenoid valve (16; 316; 416; 516; 716) presenting a second flow area for the passage of a second volume flow, with said second flow area being smaller than said first flow area so that said second volume flow is smaller than said first volume flow, wherein said first solenoid valve and said second solenoid valve are suitable for flow passage therethrough for pressure application on said actuator, characterised in that said second valve means comprises merely one solenoid valve via which the pressure on said actuator can be relieved so that there is no redundancy for relief of the pressure on said actuator.
A variant of factor IX (F.IX) or activated factor IX (F.IXa), which is characterized in that it has increased clotting activity in presence of its cofactor compared to wildtype, wherein the cofactor is factor VIII (F.VIII) or activated factor VIII (F.VIIIa), comprising at least one amino acid substitution in position 338 selected from R338A and R338L and further comprising the amino acid substitution S377W.
Bipolar plate for an electrochemical device, comprising at least one first bipolar plate layer and one second bipolar plate layer which are composed of a metallic material or of a material based on plastics and are joined to each other by a weld seam arrangement, wherein a first flow field for a first fluid medium is formed on the first bipolar plate layer, a second flow field for a second fluid medium is formed on the second bipolar plate layer, and a flow field for a third fluid medium is formed between the first bipolar plate layer and the second bipolar plate layer, and wherein the first bipolar plate layer has a first medium passage opening for the first fluid medium, a fluid connecting channel between the first medium passage opening and the first flow field, a second medium passage opening for the second fluid medium and a third medium passage opening for the third fluid medium, characterized in that the weld seam arrangement comprises a first medium channel weld seam which surrounds the first medium passage opening, a second medium channel weld seam which surrounds the second medium passage opening, and a connecting weld seam which crosses the first medium channel weld seam and the second medium channel weld seam, wherein a) the connecting weld seam is produced by means of a welding energy source which the first bipolar plate layer faced during the welding process, and the weld seam end of the connecting weld seam lies within the medium-conducting region of the bipolar plate which is surrounded by the first medium channel weld seam, and/or b) the connecting weld seam crosses the first medium channel weld seam and/or the second medium channel weld seam at least twice in each case. a) the connecting weld seam is produced by means of a welding energy source which the first bipolar plate layer faced during the welding process, and the weld seam end of the connecting weld seam lies within the medium-conducting region of the bipolar plate which is surrounded by the first medium channel weld seam, and/or b) the connecting weld seam crosses the first medium channel weld seam and/or the second medium channel weld seam at least twice in each case.
A layered heater including a substrate, characterized in that a plurality of resistive layers and a corresponding plurality of dielectric layers are formed on the substrate, the plurality of resistive layers being formed on and separated by the corresponding plurality of dielectric layers, at least one of the plurality of resistive layers being formed by a first layered process and the corresponding one of the plurality dielectric layers being formed by a second layered process, the first layered process being one of thick film, thin film, thermal spray and sol-gel processes and the second layered process being the other one of the thick film, thin film, thermal spray and sol-gel processes.
An adapter comprising: a first connector adapted for connection to a syringe; a second connector independent of the first connector adapted for connection to a catheter hub; a bridging piece disposed between and connecting the first connector and the second connector; the first connector being a proximal connector, the second connector being a distal connector; characterized by a tube connected to and extending from the proximal connector through and past the distal connector; wherein said bridging piece is configured to allow adjustment of a position of the distal connector relative to and over the tube and between the proximal connector and the distal connector. a first connector adapted for connection to a syringe; a second connector independent of the first connector adapted for connection to a catheter hub; a bridging piece disposed between and connecting the first connector and the second connector; the first connector being a proximal connector, the second connector being a distal connector; characterized by a tube connected to and extending from the proximal connector through and past the distal connector; wherein said bridging piece is configured to allow adjustment of a position of the distal connector relative to and over the tube and between the proximal connector and the distal connector.
A turbine airfoil comprising an airfoil body comprising a leading edge; a trailing edge; an exterior surface including a suction side extending from the leading edge to the trailing edge, a pressure side extending from the leading edge to a trailing end, the pressure side being located opposite to the suction side on the airfoil body, and an air gap located between the trailing end and the trailing edge and extending from the trailing end, characterised in that the complete pressure side of the exterior surface is coated by a thermal barrier coating with a thickness decreasing towards the trailing end.
A mobile terminal comprising: a flexible display; a first body configured to support a first region of the flexible display; a second body configured to support a second region of the flexible display; and a hinge rotatably coupling the first body with the second body, wherein the flexible display attached on one surface of the first body is changed from an unfolded state, in which the flexible display is configured to be flat, to a folded state, in which the flexible display is exposed on the outside of the mobile terminal, by a rotation of the first body relative to the second body, characterized in that the first body comprises a receiving space formed to be recessed on one side of the first body, wherein the receiving space is sized to receive the second body and the second region of the flexible display when the flexible display is in the folded state. a flexible display; a first body configured to support a first region of the flexible display; a second body configured to support a second region of the flexible display; and a hinge rotatably coupling the first body with the second body, wherein the flexible display attached on one surface of the first body is changed from an unfolded state, in which the flexible display is configured to be flat, to a folded state, in which the flexible display is exposed on the outside of the mobile terminal, by a rotation of the first body relative to the second body, characterized in that the first body comprises a receiving space formed to be recessed on one side of the first body, wherein the receiving space is sized to receive the second body and the second region of the flexible display when the flexible display is in the folded state.
An arrangement having a vacuum chamber and a vacuum pump which has a housing, a fast-rotating rotor arranged therein and a flange connected to the housing; and having a screw for connecting the flange to the vacuum chamber which has a chamber flange, wherein the arrangement has a holding element which has a plurality of ring segments (222a, 222b, 222c, 222d, 224a, 224b, 224c, 224d) connected to one another to form a closed ring and which is configured such that it connects the flange and the chamber flange in a form fitted manner, allows a rotation about the symmetry axis and the flange is secured by a form fit against a movement perpendicular to the flange plane, characterized in that a first share of the ring segments (222a, 222b, 222c, 222d) is in touching contact with the chamber flange and a second share of the ring segments (224a, 224b, 224c, 224d) is in touching contact with the flange, with the ring segments (222a, 222b, 222c, 222d) of the first share being arranged offset from the ring segments (224a, 224b, 224c, 224d) of the second share in the peripheral direction such that each ring segment (222a, 222b, 222c, 222d) of the first share is connected to two of the ring segments (224a, 224b, 224c, 224d) of the second share and each ring segment (224a, 224b, 224c, 224d) of the second share is connected to two of the ring segments (222a, 222b, 222c, 222d) of the first share.
A method of determining if a mesenchymal stem cell exosome comprises therapeutic activity, such that the exosome may be used to enhance tissue repair or inhibit disease progression in an autoimmune disease, the method comprising detecting immunodulatory activity of the exosome, the immunomodulatory activity being detected by detecting activity of a protein selected from the group consisting of: Biglycan (GenBank Accession Number AK092954), Endoplasmin (GenBank Accession Number AY040226), HSP60 (GenBank Accession Number M34664.1, AAA36022.1), HSP70 (GenBank Accession Number AB023420.1, BAA75062.1), β-defensin 2 (GenBank Accession Number AJ000152), Fibrinogen alpha (NCBI Reference Sequence Number NM_021871), Fibrinogen beta (NCBI Reference Sequence Number NM_001184741), Fibrinogen gamma (NCBI Reference Sequence Number NM_000509), Fibronectin (NCBI Reference Sequence Number NM_212482), Tenascin-C (NCBI Reference Sequence Number NM_002160), S100 protein S100A11 (GenBank Accession Number D38583), S100 protein S100A13 (GenBank Accession Number AK097132), S100 protein S100A8 (GenBank Accession Number BC005928), S100 protein S100A9 (GenBank Accession Number BC047681) and S100 protein S100P (GenBank Accession Number X65614) in or of the exosome, and determining that the exosome comprises therapeutic activity where such activity of a protein is detected.
Drug delivery device comprising: a cartridge with a movable bung, a drive mechanism including a bearing for driving the bung in a distal direction and a lead screw for actuating the bearing; wherein the lead screw is in threaded engagement with a body surrounding at least a proximal part of the drive mechanism and at least partly said lead screw, an electric conductor on the drive mechanism for transmitting an electrical signal, wherein the electric conductor extends through a proximal opening of said body and is configured such that a conductive connection is established or interrupted when the lead screw contacts the bearing or when the bearing contacts the bung so that the drive mechanism is in contact with the bung and actuation of the drive mechanism displaces the bung in a distal direction. a cartridge with a movable bung, a drive mechanism including a bearing for driving the bung in a distal direction and a lead screw for actuating the bearing; wherein the lead screw is in threaded engagement with a body surrounding at least a proximal part of the drive mechanism and at least partly said lead screw, an electric conductor on the drive mechanism for transmitting an electrical signal, wherein the electric conductor extends through a proximal opening of said body and is configured such that a conductive connection is established or interrupted when the lead screw contacts the bearing or when the bearing contacts the bung so that the drive mechanism is in contact with the bung and actuation of the drive mechanism displaces the bung in a distal direction.
A liquid ejection apparatus, comprising: a channel unit (20, 21) including a liquid channel including a plurality of nozzles, and a plurality of pressure chambers configured to communicate with respective nozzles; a vibration plate provided on the channel unit (20, 21) to cover the plurality of pressure chambers in a first direction from the pressure chambers, the vibration plate comprising a plate surface extending along a second direction perpendicular to the first direction; a plurality of drive elements arranged over the vibration plate in correspondence with the plurality of the pressure chambers; a plurality of wires extending along the plate surface from respective drive elements; a plurality of contact terminals (46, 48) electrically connected in correspondence with respective wires; and a flexible wiring board configured to be electrically connected to the plurality of contact terminals (46, 48), characterised in that the plurality of contact terminals (46, 48) are provided at a terminal placement surface which comprises an inclined surface inclined with respect to the plate surface. a channel unit (20, 21) including a liquid channel including a plurality of nozzles, and a plurality of pressure chambers configured to communicate with respective nozzles; a vibration plate provided on the channel unit (20, 21) to cover the plurality of pressure chambers in a first direction from the pressure chambers, the vibration plate comprising a plate surface extending along a second direction perpendicular to the first direction; a plurality of drive elements arranged over the vibration plate in correspondence with the plurality of the pressure chambers; a plurality of wires extending along the plate surface from respective drive elements; a plurality of contact terminals (46, 48) electrically connected in correspondence with respective wires; and a flexible wiring board configured to be electrically connected to the plurality of contact terminals (46, 48), characterised in that the plurality of contact terminals (46, 48) are provided at a terminal placement surface which comprises an inclined surface inclined with respect to the plate surface.