mhurhangee/ep-ind-claims huggingface dataset:
A method for producing an active-form mutant enzyme comprising: expressing, in a heterologous expression system, a gene that codes for an amino acid sequence in which at least one hydrophilic amino acid that is present in a hydrophobic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophobicity or lower hydrophilicity; and selecting a protein (hereinafter "an active-form mutant enzyme") that exhibits the same sort of activity as that obtained in the native form; or expressing, in a heterologous expression system, a gene that codes for an amino acid sequence in which at least one hydrophobic amino acid that is present in a hydrophilic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophilicity or lower hydrophobicity, and at least one hydrophilic amino acid that is present in a hydrophobic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophobicity or lower hydrophilicity; and selecting an active-form mutant enzyme; wherein the α-helix structure region is in a protein of which native form exhibits an enzyme activity but which exhibits no enzyme activity or a feeble enzyme activity when expressing a gene of the protein in a heterologous expression system (hereinafter "an inactive-form enzyme"). expressing, in a heterologous expression system, a gene that codes for an amino acid sequence in which at least one hydrophilic amino acid that is present in a hydrophobic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophobicity or lower hydrophilicity; and selecting a protein (hereinafter "an active-form mutant enzyme") that exhibits the same sort of activity as that obtained in the native form; or expressing, in a heterologous expression system, a gene that codes for an amino acid sequence in which at least one hydrophobic amino acid that is present in a hydrophilic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophilicity or lower hydrophobicity, and at least one hydrophilic amino acid that is present in a hydrophobic domain of an α-helix structure region is substituted, wherein the amino acid to be substituted is substituted to an amino acid with higher hydrophobicity or lower hydrophilicity; and selecting an active-form mutant enzyme; wherein the α-helix structure region is in a protein of which native form exhibits an enzyme activity but which exhibits no enzyme activity or a feeble enzyme activity when expressing a gene of the protein in a heterologous expression system (hereinafter "an inactive-form enzyme").
An axial piston engine with internal continuous combustion (ikV), having compressor cylinders, having working cylinders, having a ring channel, combining outlets of the compressor cylinder, or ring-channel section and having at least one pressure line connected to the ring channel or the ring-channel section, by means of which pressure line compressed fuel is conducted from the compressor cylinders to the working cylinders, characterized by a fuel reservoir, in which compressed medium can be buffer-stored, wherein a shut-off valve is arranged between the ring channel or ring-channel section and the fuel reservoir and wherein a shut-off valve is arranged in the pressure line.
A liquid oral pharmaceutical dosage form, comprising a) pharmacologically effective amounts of at least one histamine H2-receptor antagonist in a hydrophobic/lipophilic liquid being an oil substantially free from water comprising at least one viscosity enhancing agent, wherein the viscosity enhancing agent is selected from the group consisting of ethyl cellulose polymers, Lauroylpolyoxyl glycerides, glycerol dibehenate, cellulose ethyl ether, glyceryl distearate, fumed silica, or mixtures thereof and b) pharmacologically effective amounts of one or more antacid in a liquid comprising at least one viscosity enhancing agent selected from the group consisting of vegetable gums, such as alginate, guar gum, locust bean gum, xanthan gum, carrageenan, gellan gum or poly vinyl pyrrolidone, hydroxy ethyl cellulose, hydroxy propyl cellulose, microcrystalline cellulose and cellulose powders or mixtures thereof, and at least one flavor, wherein a) and b) are physically separated from each other, wherein a) and b) have matching rheological profiles, and wherein substantially free from water means that the content of water present in the composition is less than 2 wt.% based on the total wt.% of the composition. a) pharmacologically effective amounts of at least one histamine H2-receptor antagonist in a hydrophobic/lipophilic liquid being an oil substantially free from water comprising at least one viscosity enhancing agent, wherein the viscosity enhancing agent is selected from the group consisting of ethyl cellulose polymers, Lauroylpolyoxyl glycerides, glycerol dibehenate, cellulose ethyl ether, glyceryl distearate, fumed silica, or mixtures thereof and b) pharmacologically effective amounts of one or more antacid in a liquid comprising at least one viscosity enhancing agent selected from the group consisting of vegetable gums, such as alginate, guar gum, locust bean gum, xanthan gum, carrageenan, gellan gum or poly vinyl pyrrolidone, hydroxy ethyl cellulose, hydroxy propyl cellulose, microcrystalline cellulose and cellulose powders or mixtures thereof,
Use of a composition comprising paraffin, at least one alcohol, preferably selected from ethyl alcohol and isopropyl alcohol, and at least one hydrocarbon selected from naphtha, octane, isoparaffin and limonene, for the analytical preparation of biological, cytological, histological and autopsical samples, characterized in that it does not comprise ketones.
A radiant heat protection device comprising: a radiant heat reflector having a reflective surface that reflects radiant heat; a coolant retainer disposed on a back surface of the reflective surface of the radiant heat reflector and capable of retaining coolant; and a coolant feed device configured to feed the coolant to the coolant retainer, wherein the coolant feed device includes a spray nozzle configured to spray the coolant on the coolant retainer. a radiant heat reflector having a reflective surface that reflects radiant heat; a coolant retainer disposed on a back surface of the reflective surface of the radiant heat reflector and capable of retaining coolant; and a coolant feed device configured to feed the coolant to the coolant retainer, wherein the coolant feed device includes a spray nozzle configured to spray the coolant on the coolant retainer.
Poly pocket for inserting sheets of paper with a front cover and a back cover, connected by a spine stretching between a first edge and a second edge, approximately positioned opposite to the first one, characterised in that at least one of the two edges (5, 6)is only partially closed, where the closed area (7, 8) reaches to the spine, stretching over less than half the length of the edge (5, 6) on this edge (5, 6) and a clamping area for clamping the sheets of paper.
An engine control system, comprising: a first control lever configured to be coupled to an electronic engine control subsystem for one or more turbine engines, the electronic engine control subsystem configured to regulate fuel flow to the one or more turbine engines; a second control lever configured to be coupled to a backup engine control subsystem for the one or more turbine engines, the backup engine control subsystem configured to regulate fuel flow to the one or more turbine engines in the event of a failure of the electronic engine control subsystem; and a coupling device configured to selectively couple the first control lever to the second control lever with at least one angular offset, the coupling device including a support member (540, 542) having a fixed connection to the second control lever, the coupling device including a selective coupling mechanism having a fixed connection to the first control lever and a selective connection to the support member (540, 542). a first control lever configured to be coupled to an electronic engine control subsystem for one or more turbine engines, the electronic engine control subsystem configured to regulate fuel flow to the one or more turbine engines; a second control lever configured to be coupled to a backup engine control subsystem for the one or more turbine engines, the backup engine control subsystem configured to regulate fuel flow to the one or more turbine engines in the event of a failure of the electronic engine control subsystem; and a coupling device configured to selectively couple the first control lever to the second control lever with at least one angular offset, the coupling device including a support member (540, 542) having a fixed connection to the second control lever, the coupling device including a selective coupling mechanism having a fixed connection to the first control lever and a selective connection to the support member (540, 542).
A light-emitting element comprising: n, wherein n is a natural number of two or more, EL layers between an anode and a cathode; a first layer provided between an m-th, wherein m is a natural number and 1 ≤ m ≤ n -1, EL layer and an ( m + 1)-th EL layer, wherein the first layer contains a substance having electron-transport properties higher than hole-transport properties and a donor substance; a second layer provided over and in contact with the first layer and between the m- th EL layer and the ( m + 1)-th EL layer wherein the second layer contains a substance having electron-transport properties higher than hole-transport properties; and a charge-generation layer provided over and in contact with the second layer and between the m-th EL layer and the ( m + 1)-th EL layer wherein the charge-generation layer contains a substance having hole-transport properties higher than electron-transport properties and an acceptor substance, wherein the first layer, the second layer, and the charge-generation layer are provided in this order, and wherein the acceptor substance is molybdenum oxide, characterized in that the charge-generation layer does not have a peak of an absorption spectrum in a visible light region in a wavelength range of 420 nm to 720 nm, and wherein the substance having hole-transport properties higher than electron-transport properties does not contain an amine skeleton. n, wherein n is a natural number of two or more, EL layers between an anode and a cathode; a first layer provided between an m-th, wherein m is a natural number and 1 ≤ m ≤ n -1, EL layer and an ( m + 1)-th EL layer, wherein the first layer contains a substance having electron-transport properties higher than hole-transport properties and a donor substance; a second layer provided over and in contact with the first layer and between the m- th EL layer and the ( m + 1)-th EL layer wherein the second layer contains a substance having electron-transport properties higher than hole-transport properties; and a charge-generation layer provided over and in contact with the second layer and between the m-th EL layer and the ( m + 1)-th EL layer wherein the charge-generation layer contains a substance having hole-transport properties higher than electron-transport properties and an acceptor substance, wherein the first layer, the second layer, and the charge-generation layer are provided in this order, and wherein the acceptor substance is molybdenum oxide, characterized in that the charge-generation layer does not have a peak of an absorption spectrum in a visible light region in a wavelength range of 420 nm to 720 nm, and wherein the substance having hole-transport properties higher than electron-transport properties does not contain an amine skeleton.
A cable winch with automatically controlled regulation of speed of unwinding of a haulage cable, where a remotely controlled operation of the cable winch is possible and is based on the speed of a carriage at which a brake force of the cable winch can be controlled, the speed of the haulage cable being wound on a drum and led through a pulley and attached to a carriage is regulated by way of a hydraulically operated brake via braking cylinder, controlled by a hydraulic proportional valve, wherein an electronic circuit controls the proportional valve and consists of a comparator, a proportional regulator and an adder, wherein in the comparator, the desired speed of the hauling cable and the actual speed of the carriage which is detected by the sensor are compared, characterized in that the output of the comparator is connected to the input of the proportional regulator, which compares the output signal of the comparator with the signal of the function of the weighing of the load, and wherein the output signal of the proportional regulator and the input signal of a pre-controller are connected to the adder, wherein an additional function of weighing of the load is also involved in the signal of the pre-controller, which is determined on the basis of counting the pulses of the moving sensor, monitored while changing the ramp function, and where the output of the additional function of weighing of the load is also the function of changing of the proportional parameter of the regulator.
Method for supporting the discovery of synchronized clusters of mobile stations in a wireless communication network, wherein a synchronized cluster includes a number of mobile stations that periodically wake up according to a common duty cycle, characterized in that at least one mobile station of a synchronized cluster - announcement master - transmits advertising messages announcing the existence of said cluster to potential scanning devices that try to discover said cluster, wherein an independent Wi-Fi infrastructure including a plurality of Wi-Fi access points transmitting beacon frames on a regular basis, which said mobile stations are able to hear without being connected to said Wi-Fi access points, is employed as external synchronization source in that said announcement master as well as potential scanning devices apply predefined rules to derive from passively observed information contained in the beacon frames transmitted unencrypted by Wi-Fi access points of said independent Wi-Fi infrastructure time slots of said advertising messages, which are used as common rendezvous points, wherein the Timing Synchronization Function, TSF, that each Wi-Fi access point embeds into its beacon frames is used as a time coordinate system for deriving the time slots of said advertising messages, and wherein the role of said announcement master is alternated among the mobile stations of a synchronized cluster.
A vehicle comprising a refrigerator arrangement and a hybrid electric propulsion system having a control unit, a main power unit, an electrical motor-generator and an electrical storage system, and where said control unit is arranged to, upon registering a vehicle braking demand, and upon registering that said electrical storage system exhibits an upper state of charge (U SOC), or has the potential to reach said upper state of charge (U SOC) by means of regenerative braking during a predicted braking period, use at least part of the energy recovered by means of regenerative braking during a braking period following said braking demand to directly power said refrigerator arrangement, characterized in that said electrical storage system is estimated to reach said upper state of charge (U SOC) by means of regenerative braking during said predicted braking period, if a predicted amount of electrical energy converted from vehicle kinetic and/or potential energy during said predicted braking period by means of at least said electrical motor-generator equals or exceeds the predicted amount of electrical energy necessary to charge said electrical storage system to exhibit said upper state of charge (U SOC) at the end of said predicted braking period.
A method in a first network node for radio communication with a wireless device, the method comprising: - determining (2:1, 300) a first numerology for communication of a reference signal with the wireless device, the first numerology defining a first combination of subcarrier spacing and time between two successive Orthogonal Frequency-Division Multiplexing, OFDM, symbols, - determining (2:3, 302) a second numerology for communication of data between the first network node and the wireless device, the second numerology defining a second combination of subcarrier spacing and time between two successive OFDM symbols, - configuring (2:4, 304) the wireless device with the first and second numerologies where the reference signal is associated with the first numerology, and - transmitting (2:5, 306) an assignment of data in the second numerology to the wireless device, the assignment comprising a trigger for the reference signal, wherein the second numerology is signalled from the first network node to the wireless device in Downlink Control Information, DCI, and wherein the DCI comprises an indicator indicating whether the reference signal is useful for inter-node measurements or not. - determining (2:1, 300) a first numerology for communication of a reference signal with the wireless device, the first numerology defining a first combination of subcarrier spacing and time between two successive Orthogonal Frequency-Division Multiplexing, OFDM, symbols, - determining (2:3, 302) a second numerology for communication of data between the first network node and the wireless device, the second numerology defining a second combination of subcarrier spacing and time between two successive OFDM symbols, - configuring (2:4, 304) the wireless device with the first and second numerologies where the reference signal is associated with the first numerology, and - transmitting (2:5, 306) an assignment of data in the second numerology to the wireless device, the assignment comprising a trigger for the reference signal,
A refrigerator comprising a cabinet forming a storage space, a main door opening and closing the storage space and having an opening part communicated with the storage space, and a sub-door rotatably mounted on the main door and opening and closing the opening part, the refrigerator comprising: a knock detection device provided in the sub-door and detecting a user's knocking operation; wherein there is a panel assembly of a half mirror material provided in the sub-door, and allowing selectively viewing an inside of the refrigerator by a user; a lighting unit being provided inside the refrigerator, and turned on according to the verified detection of a knocking user input by the knock detection device while the door is closed to make the panel assembly appear transparent and in this way allowing viewing an inside of the refrigerator by a user; and a display unit being provided inside the refrigerator main door corresponding to the panel assembly and being visible when the lighting unit is turned on to display an operation state of the refrigerator, wherein the panel assembly comprises a front panel which forms an exterior of a front surface thereof, an insulation panel which is formed to be spaced apart from a rear surface of the front panel, and a spacer bar provided between the front panel and the insulation panel. a knock detection device provided in the sub-door and detecting a user's knocking operation; wherein there is a panel assembly of a half mirror material provided in the sub-door, and allowing selectively viewing an inside of the refrigerator by a user; a lighting unit being provided inside the refrigerator, and turned on according to the verified detection of a knocking user input by the knock detection device while the door is closed to make the panel assembly appear transparent and in this way allowing viewing an inside of the refrigerator by a user; and a display unit being provided inside the refrigerator main door corresponding to the panel assembly and being visible when the lighting unit is turned on to display an operation state of the refrigerator, wherein the panel assembly comprises a front panel which forms an exterior of a front surface thereof, an insulation panel which is formed to be spaced apart from a rear surface of the front panel, and a spacer bar provided between the front panel and the insulation panel.
A coated cutting tool comprising a substrate and a coating layer formed on a surface of the substrate, wherein: the coating layer comprises at least one α-type aluminum oxide layer, wherein an average thickness of the α-type aluminum oxide layer is from 1.0 μm or more to 15.0 μm or less, and wherein a residual stress value in a (1,1,6) plane of the α-type aluminum oxide layer is, in at least part thereof, from -300 MPa or higher to 300 MPa or lower; and in the α-type aluminum oxide layer, a texture coefficient TC (0,0,12) of a (0,0,12) plane represented by formula TC 0,0 12 = I 0,0 12 I 0 0,0 12 1 9 ∑ I h k l I 0 h k l − 1 is from 4.0 or more to 8.4 or less, and a texture coefficient TC (0,1,8) of a (0,1,8) plane represented by formula TC 0 1,8 = I 0 1,8 I 0 0 1,8 1 9 ∑ I h k l I 0 h k l − 1 is from 1.0 or more to 2.5 or less, wherein, in formulae and, I (h,k,l) denotes a peak intensity for an (h,k,l) plane in X-ray diffraction of the α-type aluminum oxide layer, I 0 (h,k,l) denotes a standard diffraction intensity for an (h,k,l) plane which is indicated on JCPDS Card No. 10-0173 for α-type aluminum oxide, and (h,k,l) refers to the nine crystal planes of (0,1,2), (1,0,4), (1,1,0), (1,1,3), (1,1,6), (0,1,8), (2,1,4), (3,0,0) and (0,0,12). the coating layer comprises at least one α-type aluminum oxide layer, wherein an average thickness of the α-type aluminum oxide layer is from 1.0 μm or more to 15.0 μm or less, and wherein a residual stress value in a (1,1,6) plane of the α-type aluminum oxide layer is, in at least part thereof, from -300 MPa or higher to 300 MPa or lower; and in the α-type aluminum oxide layer, a texture coefficient TC (0,0,12) of a (0,0,12) plane represented by formula TC 0,0 12 = I 0,0 12 I 0 0,0 12 1 9 ∑ I h k l I 0 h k l − 1 is from 4.0 or more to 8.4 or less, and a texture coefficient TC (0,1,8) of a (0,1,8) plane represented by formula TC 0 1,8 = I 0 1,8 I 0 0 1,8 1 9 ∑ I h k l I 0 h k l − 1 is from 1.0 or more to 2.5 or less, wherein, in formulae and, I (h,k,l) denotes a peak intensity for an (h,k,l) plane in X-ray diffraction of the α-type aluminum oxide layer, I 0 (h,k,l) denotes a standard diffraction intensity for an (h,k,l) plane which is indicated on JCPDS Card No. 10-0173 for α-type aluminum oxide, and (h,k,l) refers to the nine crystal planes of (0,1,2), (1,0,4), (1,1,0), (1,1,3), (1,1,6), (0,1,8), (2,1,4), (3,0,0) and (0,0,12). is from 4.0 or more to 8.4 or less, and a texture coefficient TC (0,1,8) of a (0,1,8) plane represented by formula TC 0 1,8 = I 0 1,8 I 0 0 1,8 1 9 ∑ I h k l I 0 h k l − 1 is from 1.0 or more to 2.5 or less, wherein, in formulae and, I (h,k,l) denotes a peak intensity for an (h,k,l) plane in X-ray diffraction of the α-type aluminum oxide layer, I 0 (h,k,l) denotes a standard diffraction intensity for an (h,k,l) plane which is indicated on JCPDS Card No. 10-0173 for α-type aluminum oxide, and (h,k,l) refers to the nine crystal planes of (0,1,2), (1,0,4), (1,1,0), (1,1,3), (1,1,6), (0,1,8), (2,1,4), (3,0,0) and (0,0,12).
A non-aqueous electrolyte solution for a lithium secondary battery comprising: a lithium salt; an organic solvent; and a first additive which is a compound represented by Formula 1 below: wherein in Formula 1, R1, and R2 are each independently hydrogen; or an alkyl group having 1 to 5 carbon atoms. a lithium salt; an organic solvent; and a first additive which is a compound represented by Formula 1 below: wherein in Formula 1, R1, and R2 are each independently hydrogen; or an alkyl group having 1 to 5 carbon atoms.