A photobiomodulation system, comprising: a control module comprising a housing, an electronic subassembly disposed in the housing, a connector configured to be coupled to the housing and defining a lead coupling end, a catheter coupling end, and a connector lumen extending from the lead coupling end to the catheter coupling end, and at least one light source electrically coupled to the electronic subassembly and configured to produce light in response to signals from the electronic subassembly; a lead configured to be coupled to the control module and having a distal portion spaced apart from the control module, the lead comprising a lead body defining a lead lumen that is configured for positioning in fluid communication with the connector lumen of the connector of the control module, the lead body further defining at least one opening along the distal portion of the lead and in fluid communication with the lead lumen, a plurality of light emitters arranged along the distal portion of the lead, and a plurality of optical fibers extending along the lead body and coupled to the light emitters and configured to receive light from the at least one light source and deliver the light to the light emitters; and a catheter assembly, comprising a tube coupleable to a catheter pump, and a distal connector attached to an end of the tube and configured to be coupled to the catheter coupling end of the connector of the control module, the distal connector comprising an assembly lumen extending from the tube and configured for fluid communication with the connector lumen of the connector of the connector of the control module. a control module comprising a housing, an electronic subassembly disposed in the housing, a connector configured to be coupled to the housing and defining a lead coupling end, a catheter coupling end, and a connector lumen extending from the lead coupling end to the catheter coupling end, and at least one light source electrically coupled to the electronic subassembly and configured to produce light in response to signals from the electronic subassembly; a housing, an electronic subassembly disposed in the housing, a connector configured to be coupled to the housing and defining a lead coupling end, a catheter coupling end, and a connector lumen extending from the lead coupling end to the catheter coupling end, and at least one light source electrically coupled to the electronic subassembly and configured to produce light in response to signals from the electronic subassembly; a lead configured to be coupled to the control module and having a distal portion spaced apart from the control module, the lead comprising a lead body defining a lead lumen that is configured for positioning in fluid communication with the connector lumen of the connector of the control module, the lead body further defining at least one opening along the distal portion of the lead and in fluid communication with the lead lumen, a plurality of light emitters arranged along the distal portion of the lead, and a plurality of optical fibers extending along the lead body and coupled to the light emitters and configured to receive light from the at least one light source and deliver the light to the light emitters; and a lead body defining a lead lumen that is configured for positioning in fluid communication with the connector lumen of the connector of the control module, the lead body further defining at least one opening along the distal portion of the lead and in fluid communication with the lead lumen, a plurality of light emitters arranged along the distal portion of the lead, and a plurality of optical fibers extending along the lead body and coupled to the light emitters and configured to receive light from the at least one light source and deliver the light to the light emitters; and a catheter assembly, comprising a tube coupleable to a catheter pump, and a distal connector attached to an end of the tube and configured to be coupled to the catheter coupling end of the connector of the control module, the distal connector comprising an assembly lumen extending from the tube and configured for fluid communication with the connector lumen of the connector of the connector of the control module. a tube coupleable to a catheter pump, and a distal connector attached to an end of the tube and configured to be coupled to the catheter coupling end of the connector of the control module, the distal connector comprising an assembly lumen extending from the tube and configured for fluid communication with the connector lumen of the connector of the connector of the control module.