A blocking mechanism for a skin incision device, particularly for a disposable incision device, comprising a blocking means for controlling of a firing of the blocking mechanism, and a trigger means for controlling of an actuation of the incision device, which is mounted by a locating means (3a, 3b, 1a) in the housing of the device, and is movable from an initial position to a final position, and is configured to cooperate with a lever assembly driving a blade with a cutting edge of the incision device, which lever assembly is affixed to the housing of the device, wherein the blocking mechanism is for preventing an inadvertent firing of the blocking mechanism and for preventing an inadvertent actuation of the incision device, and characterized in that, the blocking means is mounted by a fixing means (4a, 4b, 2a, 2b) in a housing of the device and is movable from a locking position to a non-locking position, and wherein the blocking mechanism is, for preventing against a re-use of the incision device and for ensuring of an unambiguous indication of a state of use of the device, the blocking means and the trigger means are provided with an engaging means (19, 18, 20) configured to mutually cooperate with each other so that the blocking means and the trigger means, before the actuation of the device, are in their respective positions mutually fixed and, after the actuation of the device, are in their respective positions mutually fixed and stationary in permanent non-reversible mutual engagement with each other. is mounted by a locating means (3a, 3b, 1a) in the housing of the device, and is movable from an initial position to a final position, and is configured to cooperate with a lever assembly driving a blade with a cutting edge of the incision device, which lever assembly is affixed to the housing of the device, wherein the blocking mechanism is for preventing an inadvertent firing of the blocking mechanism and for preventing an inadvertent actuation of the incision device, and characterized in that, the blocking means is mounted by a fixing means (4a, 4b, 2a, 2b) in a housing of the device and is movable from a locking position to a non-locking position, and wherein the blocking mechanism is, for preventing against a re-use of the incision device and for ensuring of an unambiguous indication of a state of use of the device, the blocking means and the trigger means are provided with an engaging means (19, 18, 20) configured to mutually cooperate with each other so that the blocking means and the trigger means, before the actuation of the device, are in their respective positions mutually fixed and, after the actuation of the device, are in their respective positions mutually fixed and stationary in permanent non-reversible mutual engagement with each other. the blocking means and the trigger means are provided with an engaging means (19, 18, 20) configured to mutually cooperate with each other so that the blocking means and the trigger means, before the actuation of the device, are in their respective positions mutually fixed and, after the actuation of the device, are in their respective positions mutually fixed and stationary in permanent non-reversible mutual engagement with each other.