A thrombectomy device, characterized in that the thrombectomy device comprises: a thrombus removal head having at least one opening configured to allow thrombus to enter the thrombus removal head, and the thrombus removal head being connected to a sheath; a thrombus fragmentation system comprising an operating assembly, a gear assembly, a transmission tube and a thrombus fragmentation cutter, wherein the operating assembly drives the transmission tube to rotate through the gear assembly, and a distal end of the transmission tube is connected to the thrombus fragmentation cutter; and a thrombus aspiration system comprising a connecting member, an aspiration assembly, a drainage tube and a liquid inlet tube, wherein one end of the connecting member is connected to the operating assembly, and a further end of the connecting member is connected to the aspiration assembly; when driven by the operating assembly, the connecting member drives the aspiration assembly to form a pressure chamber; the pressure chamber is connected to the drainage tube and the liquid inlet tube; and the liquid inlet tube is connected to the sheath, wherein the aspiration assembly comprises an aspiration chamber, a piston, and a piston rod; the piston sleeves over the piston rod and is tangential with an inner surface of the aspiration chamber; one end of the piston rod away from the piston is connected to the connecting member, and wherein a negative pressure is generated in the pressure chamber when an acting force is applied to the operating assembly, and a positive pressure is generated in the pressure chamber when no acting force is applied to the operating assembly. a thrombus removal head having at least one opening configured to allow thrombus to enter the thrombus removal head, and the thrombus removal head being connected to a sheath; a thrombus fragmentation system comprising an operating assembly, a gear assembly, a transmission tube and a thrombus fragmentation cutter, wherein the operating assembly drives the transmission tube to rotate through the gear assembly, and a distal end of the transmission tube is connected to the thrombus fragmentation cutter; and a thrombus aspiration system comprising a connecting member, an aspiration assembly, a drainage tube and a liquid inlet tube, wherein one end of the connecting member is connected to the operating assembly, and a further end of the connecting member is connected to the aspiration assembly; when driven by the operating assembly, the connecting member drives the aspiration assembly to form a pressure chamber; the pressure chamber is connected to the drainage tube and the liquid inlet tube; and the liquid inlet tube is connected to the sheath, wherein the aspiration assembly comprises an aspiration chamber, a piston, and a piston rod; the piston sleeves over the piston rod and is tangential with an inner surface of the aspiration chamber; one end of the piston rod away from the piston is connected to the connecting member, and wherein a negative pressure is generated in the pressure chamber when an acting force is applied to the operating assembly, and a positive pressure is generated in the pressure chamber when no acting force is applied to the operating assembly.