An embolic protection system for isolating the cerebral vasculature, the system comprising: a first protection device having a proximal portion configured to remain outside the body and a distal portion, the distal portion comprising: a proximal sheath; a proximal self-expanding filter assembly radially within the proximal sheath; a distal sheath; and a distal self-expanding filter assembly radially within the distal sheath; a second protection device (100, 200, 300, 700, 800, 900) having a proximal portion configured to remain outside the body and a distal portion (102, 202, 302, 702, 802, 902), the distal portion (102, 202, 302, 702, 802, 902) comprising: an outer sheath (110, 204, 304, 704, 804, 904); an inner member radially within the outer sheath (110, 204, 304, 704, 804, 904), wherein the inner member comprises a wire (120, 212, 312, 712, 812, 912); and a third filter assembly (122, 210, 310, 710, 810, 910) radially within the outer sheath (110, 204, 304, 704, 804, 904) and coupled to the wire (120, 212, 312, 712, 812, 912), wherein the wire (120, 212, 312, 712, 812, 912) is woven into the third self-expanding filter assembly (122, 210, 310, 710, 810, 910) adjacent a distal end of the third filter assembly (122, 210, 310, 710, 810, 910). a first protection device having a proximal portion configured to remain outside the body and a distal portion, the distal portion comprising: a proximal sheath; a proximal self-expanding filter assembly radially within the proximal sheath; a distal sheath; and a distal self-expanding filter assembly radially within the distal sheath; a proximal sheath; a proximal self-expanding filter assembly radially within the proximal sheath; a distal sheath; and a distal self-expanding filter assembly radially within the distal sheath; a second protection device (100, 200, 300, 700, 800, 900) having a proximal portion configured to remain outside the body and a distal portion (102, 202, 302, 702, 802, 902), the distal portion (102, 202, 302, 702, 802, 902) comprising: an outer sheath (110, 204, 304, 704, 804, 904); an inner member radially within the outer sheath (110, 204, 304, 704, 804, 904), wherein the inner member comprises a wire (120, 212, 312, 712, 812, 912); and a third filter assembly (122, 210, 310, 710, 810, 910) radially within the outer sheath (110, 204, 304, 704, 804, 904) and coupled to the wire (120, 212, 312, 712, 812, 912), wherein the wire (120, 212, 312, 712, 812, 912) is woven into the third self-expanding filter assembly (122, 210, 310, 710, 810, 910) adjacent a distal end of the third filter assembly (122, 210, 310, 710, 810, 910). an outer sheath (110, 204, 304, 704, 804, 904); an inner member radially within the outer sheath (110, 204, 304, 704, 804, 904), wherein the inner member comprises a wire (120, 212, 312, 712, 812, 912); and a third filter assembly (122, 210, 310, 710, 810, 910) radially within the outer sheath (110, 204, 304, 704, 804, 904) and coupled to the wire (120, 212, 312, 712, 812, 912), wherein the wire (120, 212, 312, 712, 812, 912) is woven into the third self-expanding filter assembly (122, 210, 310, 710, 810, 910) adjacent a distal end of the third filter assembly (122, 210, 310, 710, 810, 910).