mhurhangee/ep-ind-claims huggingface dataset:
Method for the surveillance, diagnosis and screening of a bladder cancer, or a risk of developing a bladder cancer in a subject, wherein said method comprises: a) a step of detecting a mutation in the FGFR3 gene in a first biological sample; and b) a step of measuring the degree of methylation of at least two genes selected from the group consisting of SEPTIN 9, SLIT 2, TWIST 1, HS3ST2 and fragments thereof in a second biological sample obtained from said subject, wherein said first and second biological samples are the same biological sample; and said step a) is performed by: - detecting a mutation selected from the group consisting of 742C→T, 746C→G, 1114G→T, and 1124A→G by reference to the nucleotide numbers of SEQ ID N°1; or - detecting a mutation in the group consisting of mutations Arg248Cys, Ser249Cys, Gly372Cys, and Tyr375Cys, by reference to the aminoacid numbers of SEQ ID N°2. a) a step of detecting a mutation in the FGFR3 gene in a first biological sample; and b) a step of measuring the degree of methylation of at least two genes selected from the group consisting of SEPTIN 9, SLIT 2, TWIST 1, HS3ST2 and fragments thereof in a second biological sample obtained from said subject, - detecting a mutation selected from the group consisting of 742C→T, 746C→G, 1114G→T, and 1124A→G by reference to the nucleotide numbers of SEQ ID N°1; or - detecting a mutation in the group consisting of mutations Arg248Cys, Ser249Cys, Gly372Cys, and Tyr375Cys, by reference to the aminoacid numbers of SEQ ID N°2.
A flexible pipe body comprising apparatus for providing a thermal insulation layer in a flexible pipe, characterised in that the apparatus comprises: one or more encapsulated regions (301, 1201, 1501) of aerogel material disposed in a layer of the flexible pipe body, said one or more regions comprising an encapsulated channel region in a cross section of a tape (300, 490, 590) forming a helically wound tape layer, said channel region being at least partially filled with said aerogel material, adjacent windings and respective encapsulated channel regions extending as a layer along the flexible pipe body, the cross section of said tape further comprising a valley region and a hook region that interlock adjacent windings in said tape layer. one or more encapsulated regions (301, 1201, 1501) of aerogel material disposed in a layer of the flexible pipe body, said one or more regions comprising an encapsulated channel region in a cross section of a tape (300, 490, 590) forming a helically wound tape layer, said channel region being at least partially filled with said aerogel material, adjacent windings and respective encapsulated channel regions extending as a layer along the flexible pipe body, the cross section of said tape further comprising a valley region and a hook region that interlock adjacent windings in said tape layer.
A scrubbing accessory comprising a base portion capable of being connected to a cleaning device on the one hand and to a handle on the other hand, the base portion having a main axis collinear with the axis of the handle, a scrubbing portion provided with a scrubbing device, and a hinge pivotally connecting the scrubbing portion to the base portion, the scrubbing portion being freely maneuverable with respect to the base portion between a stable working position, in which the scrubbing device is directed toward the lower half-space (Ea) defined by a plane transverse to the main axis and passing through the base portion, and a stable withdrawn position, in which the scrubbing device is directed toward the upper half-space (Eb) defined by said plane, characterized in that the pivoting of the scrubbing portion occurs in a plane which does not include the main axis.
A control system for a vehicle, comprising: a steering angle detector configured to detect a steering angle of a steering wheel, the steering wheel mounted on the vehicle; a speed detector configured to detect a traveling speed of the vehicle; a reaction-force generator configured to generate a reaction force of the steering wheel; and a controller electrically connected with the steering angle detector, the speed detector, and the reaction-force generator, the controller is configured to calculate a lateral acceleration based on the traveling speed and the steering angle, characterized in that the controller is configured to: set the reaction force, wherein a ratio of the reaction force to the steering angle increases as the calculated lateral acceleration increases; and control the reaction-force generator so that the reaction force generated by the reaction-force generator becomes the set reaction-force. a steering angle detector configured to detect a steering angle of a steering wheel, the steering wheel mounted on the vehicle; a speed detector configured to detect a traveling speed of the vehicle; a reaction-force generator configured to generate a reaction force of the steering wheel; and a controller electrically connected with the steering angle detector, the speed detector, and the reaction-force generator, the controller is configured to calculate a lateral acceleration based on the traveling speed and the steering angle, characterized in that the controller is configured to: set the reaction force, wherein a ratio of the reaction force to the steering angle increases as the calculated lateral acceleration increases; and control the reaction-force generator so that the reaction force generated by the reaction-force generator becomes the set reaction-force. set the reaction force, wherein a ratio of the reaction force to the steering angle increases as the calculated lateral acceleration increases; and control the reaction-force generator so that the reaction force generated by the reaction-force generator becomes the set reaction-force.
An immunogenic composition comprising: (i) 0.004 ng/mL Koch's tuberculin (ii) 0.004 g/mL purified protein derivative of Koch's bacillus (iii) 6.94 μg/mL inactivated Staphylococcus lysate consisting of Staphylococcus aureus and Staphylococcus epidermidis in equal parts (iv) 6.94 μg/mL inactivated Streptococcus lysate consisting of Streptococcus pyogenes, Streptococcus pneumoniae and Enterococcus faecalis in equal parts (v) 0.444 μg/mL streptokinase derived from inactivated beta-hemolytic Streptococcus lysate purification (vi) 0.111 μg/mL dornase derived from inactivated beta-hemolytic Streptococcus lysate purification (vii) 6.94 μg/mL inactivated Candida lysate consisting of Candida albicans and Candida glabrata in equal parts (viii) 6.94 μg/mL inactivated dermatophytes lysate consisting of Epidermophyton floccosum, Microsporum cannis and Trichophyton mentagrophytes of the interdigitale variety in equal parts (ix) 6.94 μg/mL inactivated enteropathogenic Escherichia coli lysate (x) 6.94 μg/mL inactivated Salmonella lysate consisting of Salmonella bongori, Salmonella enterica and Salmonella subterranea in equal parts (xi) 7.5 mg/mL sodium chloride (xii) 0.48 mg/mL sodium phosphate dibasic heptahydrate (xiii) 0.06 mg/mL potassium phosphate monobasic (xiv) 2.5 mg/mL phenol; (xv) water; and IL-2 for use in therapy. (i) 0.004 ng/mL Koch's tuberculin (ii) 0.004 g/mL purified protein derivative of Koch's bacillus (iii) 6.94 μg/mL inactivated Staphylococcus lysate consisting of Staphylococcus aureus and Staphylococcus epidermidis in equal parts (iv) 6.94 μg/mL inactivated Streptococcus lysate consisting of Streptococcus pyogenes, Streptococcus pneumoniae and Enterococcus faecalis in equal parts (v) 0.444 μg/mL streptokinase derived from inactivated beta-hemolytic Streptococcus lysate purification (vi) 0.111 μg/mL dornase derived from inactivated beta-hemolytic Streptococcus lysate purification (vii) 6.94 μg/mL inactivated Candida lysate consisting of Candida albicans and Candida glabrata in equal parts (viii) 6.94 μg/mL inactivated dermatophytes lysate consisting of Epidermophyton floccosum, Microsporum cannis and Trichophyton mentagrophytes of the interdigitale variety in equal parts (ix) 6.94 μg/mL inactivated enteropathogenic Escherichia coli lysate (x) 6.94 μg/mL inactivated Salmonella lysate consisting of Salmonella bongori, Salmonella enterica and Salmonella subterranea in equal parts (xi) 7.5 mg/mL sodium chloride (xii) 0.48 mg/mL sodium phosphate dibasic heptahydrate (xiii) 0.06 mg/mL potassium phosphate monobasic (xiv) 2.5 mg/mL phenol; (xv) water; and IL-2 for use in therapy.
A nasal formulation comprising as an active ingredient a centrally-acting peptide derivative, said peptide derivative comprising a portion that acts on a central nervous system, a cell-penetrating sequence portion in which half or more of the total amino acid residues are basic amino acid residues, and an endosomal-escape portion selected from the group consisting of FFLIPKG, LILIG, FFG, FFFFG and FFFFFFG for use in therapy, wherein the formulation is administered nasally.
A porous metallic body comprising a three-dimensional network structure composed of an alloy containing at least Ni and Cr, wherein the porous metallic body has a skeleton formed of a hollow core and a shell, and wherein when a cross section of the shell is evenly divided in the thickness direction into three portions, i.e., an outer portion, a central portion, and an inner portion, and when concentrations in percent by weight of Cr in the outer portion, the central portion, and the inner portions are defined as symbols a, b, and c, the symbols a, b, and c satisfy the relation given by expression: a + c / 2 − b / a + b + c / 3 < 0.20 wherein a>b and c>b.
Method for determining the geographical position and orientation of a vehicle, in which - an image of the vehicle environment is captured with at least one camera of the vehicle, wherein the captured image at least partially comprises regions of the vehicle environment at the ground level; - an item of classification information is generated for the individual pixels of the captured image, which item of classification information indicates an assignment to one of a plurality of predetermined object classes, and a semantic segmentation of the image is carried out on the basis of this assignment; ground texture transitions, i.e., transitions to other object classes on the ground plane, are detected on the basis of the semantic segmentation of the image; - only the pixels of the detected ground texture transitions are projected onto the ground level of the vehicle environment; the deviation between the ground texture transitions projected onto the ground level of the vehicle environment and ground texture transitions in a global reference map is minimized (7, 8, 9); and - the current position and orientation of the vehicle in space is output on the basis of the minimized deviation. - an image of the vehicle environment is captured with at least one camera of the vehicle, wherein the captured image at least partially comprises regions of the vehicle environment at the ground level; - an item of classification information is generated for the individual pixels of the captured image, which item of classification information indicates an assignment to one of a plurality of predetermined object classes, and a semantic segmentation of the image is carried out on the basis of this assignment; ground texture transitions, i.e., transitions to other object classes on the ground plane, are detected on the basis of the semantic segmentation of the image; - only the pixels of the detected ground texture transitions are projected onto the ground level of the vehicle environment; the deviation between the ground texture transitions projected onto the ground level of the vehicle environment and ground texture transitions in a global reference map is minimized (7, 8, 9); and - the current position and orientation of the vehicle in space is output on the basis of the minimized deviation.
A dosimetry device that is connectable to a phototherapy apparatus to apply targeted phototherapy to a treatment area, the dosimetry device comprising: a housing including an optical matrix having a plurality of at least one of absorptive, reflective and partially transmissive regions that are at least one of connected to the housing and formed within the housing, wherein each of the plurality of absorptive, reflective and partially transmissive regions each permits a different transmission of light to pass therethrough simultaneously when a single dose of UVB light in a narrow band, monochromatic wavelength at approximately 308 nm is transmitted by the phototherapy apparatus and supplied to the dosimetry device that is releasably connected to the optical matrix to produce a plurality of doses of varying levels of UVB light through the optical matrix, so as to determine a minimum blistering dose of the treatment area to allow treatment of the treatment area at a maximum tolerable dose. a housing including an optical matrix having a plurality of at least one of absorptive, reflective and partially transmissive regions that are at least one of connected to the housing and formed within the housing, wherein each of the plurality of absorptive, reflective and partially transmissive regions each permits a different transmission of light to pass therethrough simultaneously when a single dose of UVB light in a narrow band, monochromatic wavelength at approximately 308 nm is transmitted by the phototherapy apparatus and supplied to the dosimetry device that is releasably connected to the optical matrix to produce a plurality of doses of varying levels of UVB light through the optical matrix, so as to determine a minimum blistering dose of the treatment area to allow treatment of the treatment area at a maximum tolerable dose.
A compound represented by the following general formula, or an N-oxide or agrochemically acceptable salt thereof: wherein: A is N; D is a hydrogen; E is a phenyl group; Y is an oxygen atom which bonds to any sites of E; R 1 is a hydrogen; R 2 is -OR 7, wherein R 7 is a C 1 -C 6 -alkyl group; Z is a phenyl group; R 3 is a halogen group, a cyano group, a C 1 -C 4 -alkyl group, a C 1 -C 4 -haloalkyl group, or a C 1 -C 4 -alkoxy group; R 4 is a halogen group, a cyano group, a C 1 -C 4 -alkyl group, a C 1 -C 4 -haloalkyl group, a C 1 -C 4 -alkoxy group, or a C 1 -C 4 -haloalkoxy group; m R 4 are bonded to any substitution sites, wherein m is 1, 2, 3, 4, or 5; n R 3 are bonded to any substitution sites, wherein n is 0, 1, 2, 3, or 4. A is N; D is a hydrogen; E is a phenyl group; Y is an oxygen atom which bonds to any sites of E; R 1 is a hydrogen; R 2 is -OR 7, wherein R 7 is a C 1 -C 6 -alkyl group; Z is a phenyl group; R 3 is a halogen group, a cyano group, a C 1 -C 4 -alkyl group, a C 1 -C 4 -haloalkyl group, or a C 1 -C 4 -alkoxy group; R 4 is a halogen group, a cyano group, a C 1 -C 4 -alkyl group, a C 1 -C 4 -haloalkyl group, a C 1 -C 4 -alkoxy group, or a C 1 -C 4 -haloalkoxy group; m R 4 are bonded to any substitution sites, wherein m is 1, 2, 3, 4, or 5; n R 3 are bonded to any substitution sites, wherein n is 0, 1, 2, 3, or 4.
A composition comprising tafluprost and isopropyl myristate, wherein the composition comprises between 1 percent and 20 percent isopropyl myristate, by weight of the total weight of the composition.
Shower device, comprising - a shower head housing which comprises a jet disk having a multiplicity of jet outlet openings (8, 8a), which form a plurality of groups of jet outlet openings (8, 8a), - a water conduit (5, 14, 23) from a water inlet into the shower head housing, and - at least two chambers (12, 21) formed in the shower head housing which are arranged consecutively behind the jet disk in the shower head housing and are fluidly coupled in parallel to the water inlet via the water conduit and of which chambers at least one chamber is exclusively for the water supply to one of the plurality of groups of jet outlet openings and each chamber (12, 21) is for the water supply to at least one of the plurality of groups of jet outlet openings, characterized in that - the jet outlet openings of at least one of the plurality of groups of jet outlet openings lead through channels that pass through the front chamber as viewed relative to the jet disk into the rear chamber as viewed relative to the jet disk, and/or - the rear chamber as viewed relative to the jet disk comprises distinct jet outlet openings which lead into the front chamber as viewed relative to the jet disk, are aligned relative to the jet outlet openings leading out of the front chamber, and have a smaller diameter than the latter openings. - a shower head housing which comprises a jet disk having a multiplicity of jet outlet openings (8, 8a), which form a plurality of groups of jet outlet openings (8, 8a), - a water conduit (5, 14, 23) from a water inlet into the shower head housing, and - at least two chambers (12, 21) formed in the shower head housing which are arranged consecutively behind the jet disk in the shower head housing and are fluidly coupled in parallel to the water inlet via the water conduit and of which chambers at least one chamber is exclusively for the water supply to one of the plurality of groups of jet outlet openings and each chamber (12, 21) is for the water supply to at least one of the plurality of groups of jet outlet openings, - the jet outlet openings of at least one of the plurality of groups of jet outlet openings lead through channels that pass through the front chamber as viewed relative to the jet disk into the rear chamber as viewed relative to the jet disk, and/or - the rear chamber as viewed relative to the jet disk comprises distinct jet outlet openings which lead into the front chamber as viewed relative to the jet disk, are aligned relative to the jet outlet openings leading out of the front chamber, and have a smaller diameter than the latter openings.
A method for improving quality of poultry meat, comprising administration to poultry birds of a phytogenic feed supplement provided in the form of an aqueous ethanol extract and comprising, as a functional ingredient, a substance extracted from dry, fresh or ensilaged phytomass of Amaranthus L., in particular of Amaranthus cruentus L., wherein said phytogenic feed supplement is administered, via drinking water, to newly hatched broiler chickens during the first days of life in an effective daily amount comprising 0,2-6 g per kg of live weight; or wherein said phytogenic feed supplement is administered, via feed formula, to broiler chickens during rearing period, in particular, from the first day of life and/or later until slaughtering in an effective daily amount comprising 0,3-60 mg, preferably 0,3-5,4 mg, per kg of live weight, wherein the effective daily amount corresponds to an amount of dry substance extracted from phytomass of Amaranthus.
A method implemented in a network apparatus to map virtual networks over a wavelength division multiplexing, WDM, optical network, the method comprising: (a) selecting unconsidered virtual link ( i,j) with a maximum cost, a cost being requested line rate r ij on VL( i,j) × shortest distance between nodes i and j; (b) selecting unconsidered route k out of K -shortest routes between nodes i and j of VL( i, j); (c) determining a bit map of unconsidered route k, wherein a bit map indicates whether a wavelength slot of the spectrum of a route is available or not; (d) finding a modulation format that supports requested line rate r ij with minimum spectrum ⌈ r ij s z ⌉, where S z is spectral efficiency when a channel is transmitted using the modulation format; (e) finding ⌈ r ij s z ⌉ consecutive spectrum slots at M lowest wavelengths in the bit map of selected route k; and (f) determining fragmentation factor F k m after provisioning a channel at each wavelength m on selected route k, where 1 ≤ m ≤ M, wherein the fragmentation factor is determined according to the following formula: FF = 1 − 1 T ∑ ∀ s d 1 K ∑ k = 1 k = K ∑ l ∈ L Q l × α l s, d, k, where T is granularity at which a spectrum is slotted, ( s, d) ( s, d ∈ V and | V | ≤ K, where V is a set of reconfigurable optical add-drop multiplexer nodes) denotes a node pair, L is an offered set of line rates, l denotes a line rate, α l s,d,k denotes the probability of provisioning a connection with a line rate l on a route k between an (s, d) node pair, and Q l denotes the probability of requesting a line rate l. (a) selecting unconsidered virtual link ( i,j) with a maximum cost, a cost being requested line rate r ij on VL( i,j) × shortest distance between nodes i and j; (b) selecting unconsidered route k out of K -shortest routes between nodes i and j of VL( i, j); (c) determining a bit map of unconsidered route k, wherein a bit map indicates whether a wavelength slot of the spectrum of a route is available or not; (d) finding a modulation format that supports requested line rate r ij with minimum spectrum ⌈ r ij s z ⌉, where S z is spectral efficiency when a channel is transmitted using the modulation format; (e) finding ⌈ r ij s z ⌉ consecutive spectrum slots at M lowest wavelengths in the bit map of selected route k; and (f) determining fragmentation factor F k m after provisioning a channel at each wavelength m on selected route k, where 1 ≤ m ≤ M, wherein the fragmentation factor is determined according to the following formula: FF = 1 − 1 T ∑ ∀ s d 1 K ∑ k = 1 k = K ∑ l ∈ L Q l × α l s, d, k, where T is granularity at which a spectrum is slotted, ( s, d) ( s, d ∈ V and | V | ≤ K, where V is a set of reconfigurable optical add-drop multiplexer nodes) denotes a node pair, L is an offered set of line rates, l denotes a line rate, α l s,d,k denotes the probability of provisioning a connection with a line rate l on a route k between an (s, d) node pair, and Q l denotes the probability of requesting a line rate l.