A device for thermoacoustic sensing, in particular thermoacoustic imaging, the device comprising a) an irradiation unit configured to - generate electromagnetic or particle radiation, - modulate an intensity and/or frequency of the electromagnetic or particle radiation, respectively, with a first modulation, the first modulation comprising at least two modulation components at distinct frequencies, and - continuously emit the modulated electromagnetic or particle radiation, respectively, towards a target, whereby acoustic waves are continuously generated in the target, the acoustic waves exhibiting a second modulation, the second modulation comprising acoustic wave components at the distinct frequencies of the at least two modulation components and/or at harmonic frequencies of the distinct frequencies of the at least two modulation components, b) a detection unit configured to simultaneously detect the acoustic waves exhibiting the second modulation while the modulated electromagnetic or particle radiation, respectively, is being continuously emitted towards the target, whereby the acoustic wave components at the distinct frequencies and/or at the harmonic frequencies are detected, and c) a processing unit configured to determine thermoacoustic values of an amplitude and/or a phase of each of the acoustic wave components at the distinct frequencies of the at least two modulation components and/or the harmonic frequencies of the distinct frequencies of the at least two modulation components. a) an irradiation unit configured to - generate electromagnetic or particle radiation, - modulate an intensity and/or frequency of the electromagnetic or particle radiation, respectively, with a first modulation, the first modulation comprising at least two modulation components at distinct frequencies, and - continuously emit the modulated electromagnetic or particle radiation, respectively, towards a target, whereby acoustic waves are continuously generated in the target, the acoustic waves exhibiting a second modulation, the second modulation comprising acoustic wave components at the distinct frequencies of the at least two modulation components and/or at harmonic frequencies of the distinct frequencies of the at least two modulation components, - generate electromagnetic or particle radiation, - modulate an intensity and/or frequency of the electromagnetic or particle radiation, respectively, with a first modulation, the first modulation comprising at least two modulation components at distinct frequencies, and - continuously emit the modulated electromagnetic or particle radiation, respectively, towards a target, whereby acoustic waves are continuously generated in the target, the acoustic waves exhibiting a second modulation, the second modulation comprising acoustic wave components at the distinct frequencies of the at least two modulation components and/or at harmonic frequencies of the distinct frequencies of the at least two modulation components, b) a detection unit configured to simultaneously detect the acoustic waves exhibiting the second modulation while the modulated electromagnetic or particle radiation, respectively, is being continuously emitted towards the target, whereby the acoustic wave components at the distinct frequencies and/or at the harmonic frequencies are detected, and c) a processing unit configured to determine thermoacoustic values of an amplitude and/or a phase of each of the acoustic wave components at the distinct frequencies of the at least two modulation components and/or the harmonic frequencies of the distinct frequencies of the at least two modulation components.