A system for providing respiratory therapy to a subject having an airway, the system comprising: a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of the subject; one or more sensors configured to generated output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; one or more processors configured to execute processing modules, the processing modules comprising: a therapy amount module configured to determine an amount of time the subject received respiratory therapy during a first therapy session, wherein a therapy session is defined as a period of substantially uninterrupted therapeutic usage of the system, a compliance module configured to determine whether said determined amount of time meets and/or passes a threshold amount of time of respiratory therapy; a target module configured to determine a target pressure for the pressurized flow of breathable gas during therapy sessions based on a prescribed therapy regimen and determinations by the compliance module pertaining to prior therapy sessions such that, for a second therapy session subsequent to the first therapy session, the target module determines the target pressure for the pressurized flow of breathable gas based on a determination by the compliance module pertaining to the first therapy session; and a control module configured to adjust levels of one or more gas parameters of the pressurized flow of breathable gas based on the determined target pressure, characterized in that the one or more processors further comprising: a randomness module configured to determine a measure of randomness in a breathing pattern of the subject during the first therapy session through statistical analysis of durations of inhalations, wherein determinations by the compliance module are based on the measure of randomness determined by the randomness module. a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of the subject; one or more sensors configured to generated output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; one or more processors configured to execute processing modules, the processing modules comprising: a therapy amount module configured to determine an amount of time the subject received respiratory therapy during a first therapy session, wherein a therapy session is defined as a period of substantially uninterrupted therapeutic usage of the system, a compliance module configured to determine whether said determined amount of time meets and/or passes a threshold amount of time of respiratory therapy; a target module configured to determine a target pressure for the pressurized flow of breathable gas during therapy sessions based on a prescribed therapy regimen and determinations by the compliance module pertaining to prior therapy sessions such that, for a second therapy session subsequent to the first therapy session, the target module determines the target pressure for the pressurized flow of breathable gas based on a determination by the compliance module pertaining to the first therapy session; and a control module configured to adjust levels of one or more gas parameters of the pressurized flow of breathable gas based on the determined target pressure, a therapy amount module configured to determine an amount of time the subject received respiratory therapy during a first therapy session, wherein a therapy session is defined as a period of substantially uninterrupted therapeutic usage of the system, a compliance module configured to determine whether said determined amount of time meets and/or passes a threshold amount of time of respiratory therapy; a target module configured to determine a target pressure for the pressurized flow of breathable gas during therapy sessions based on a prescribed therapy regimen and determinations by the compliance module pertaining to prior therapy sessions such that, for a second therapy session subsequent to the first therapy session, the target module determines the target pressure for the pressurized flow of breathable gas based on a determination by the compliance module pertaining to the first therapy session; and a control module configured to adjust levels of one or more gas parameters of the pressurized flow of breathable gas based on the determined target pressure, characterized in that the one or more processors further comprising: a randomness module configured to determine a measure of randomness in a breathing pattern of the subject during the first therapy session through statistical analysis of durations of inhalations, wherein determinations by the compliance module are based on the measure of randomness determined by the randomness module.