mhurhangee/ep-ind-claims huggingface dataset:
An agent that selectively reduces cystatin C (CysC) levels and/or activity in a cell or tissue for use in a method of treating Alzheimer's disease, cerebral angiopathy, cerebral hemorrhage or immunotherapy-induced microhemorrhage in a subject by reducing the level of amyloid beta protein in a cell or a tissue in the subject, wherein reduction of CysC levels and/or activity results in a reduced level of amyloid beta protein in the cell or tissue, wherein the agent is an interfering nucleic acid that reduces the level of CysC expression in the cell or tissue, a dominant negative mutant of CysC, a nucleic acid comprising a nucleotide sequence encoding a dominant negative mutant of CysC, an antibody that specifically binds CysC or a peptide fragment of cystatin C that inhibits binding of cystatin C to cathepsin B.
A process for preparing a thermoplastic polymer by reacting at least components (i) to (ii) i) a polyisocyanate composition comprising at least one diisocyanate; ii) an epoxide composition comprising at least one diepoxide; in the presence of a catalyst composition (iii); wherein a) epoxide composition (ii) and catalyst composition (iii) are initially charged as a mixture at a temperature in a first temperature range (T 1); b) the polyisocyanate composition (i) is at least partially added while maintaining a temperature in the first temperature range T 1; c) the temperature is raised to a temperature in a final temperature range (T f); d) the remaining polyisocyanate composition (i) is added in the final temperature range. i) a polyisocyanate composition comprising at least one diisocyanate; ii) an epoxide composition comprising at least one diepoxide; a) epoxide composition (ii) and catalyst composition (iii) are initially charged as a mixture at a temperature in a first temperature range (T 1); b) the polyisocyanate composition (i) is at least partially added while maintaining a temperature in the first temperature range T 1; c) the temperature is raised to a temperature in a final temperature range (T f); d) the remaining polyisocyanate composition (i) is added in the final temperature range.
A method performed by a base station in a wireless communication system, the method comprising: receiving, from a first core network entity (903, 904), information indicating that the first core network entity (903, 904) is unavailable; transmitting to a terminal, information indicating that the first core network entity is unavailable; receiving (935, 940), from the terminal, a first message for requesting a registration, wherein the first message does not include information for identifying a core network entity; selecting a second core network entity (903, 904) as the first message does not include the information for identifying a core network entity; and transmitting, to the second core network entity, a second message including the first message. receiving, from a first core network entity (903, 904), information indicating that the first core network entity (903, 904) is unavailable; transmitting to a terminal, information indicating that the first core network entity is unavailable; receiving (935, 940), from the terminal, a first message for requesting a registration, wherein the first message does not include information for identifying a core network entity; selecting a second core network entity (903, 904) as the first message does not include the information for identifying a core network entity; and transmitting, to the second core network entity, a second message including the first message.
A process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound to the tie layer wherein the bifunctional compound comprises an ethylenically unsaturated double bond; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bonds, wherein the covalent bonding between the tie layer and the bifunctional compound comprising an ethylenically unsaturated double bond occurs via reaction of a hydroxy, amino, alkylamine, thiol or carboxy group, of the tie layer with an isocyanato, azlactone, epoxy, carboxy anhydride, carboxy or hydroxy group, of the ethylenically unsaturated compound. (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound to the tie layer wherein the bifunctional compound comprises an ethylenically unsaturated double bond; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bonds,
A disc wheel with variable thickness for agricultural tractor application comprising: an axle mounting area having a thickness T; an axle mounting radius area connecting to a wheel weight mounting area; a connection bracket mounting area having a thickness T3 same as the thickness T of the axle mounting area; characterized in that, said thickness of the disc wheel includes maximum thicknessT at the axle mounting area and at the connection bracket mounting area; wherein said thickness T from the axle mounting area gradually decreases up to the end of the wheel weight mounting area and matches the thickness T3 at the connection bracket mounting area; wherein the thickness T2 of the wheel weight mounting area is less than the thickness T1 of the axle mounting radius area and the thickness T1 of the axle mounting radius area is less than the thickness T of the axle mounting area; and wherein the connection bracket mounting area is parallel to the axle mounting area an axle mounting area having a thickness T; an axle mounting radius area connecting to a wheel weight mounting area; a connection bracket mounting area having a thickness T3 same as the thickness T of the axle mounting area; characterized in that, said thickness of the disc wheel includes maximum thicknessT at the axle mounting area and at the connection bracket mounting area; wherein said thickness T from the axle mounting area gradually decreases up to the end of the wheel weight mounting area and matches the thickness T3 at the connection bracket mounting area; wherein the thickness T2 of the wheel weight mounting area is less than the thickness T1 of the axle mounting radius area and the thickness T1 of the axle mounting radius area is less than the thickness T of the axle mounting area; and wherein the connection bracket mounting area is parallel to the axle mounting area
A walker, comprising: a walker body; a handle unit, connected to the walker body; a first wheel unit, connected to the walker body; a second wheel unit, connected to the walker body, wherein in an auxiliary mode, a first gap is formed between the first wheel unit and the second wheel unit, and in a driving mode, a second gap is formed between the first wheel unit and the second wheel unit, and the first gap is smaller than the second gap; and a gear set, wherein the gear set is connected to the walker body, the handle unit is directly connected to the gear set, and the second wheel unit is connected to the gear set, wherein the handle unit drives the gear set, wherein the gear set comprises a first gear, a second gear and a third gear, the handle unit comprises a handle linkage, the second wheel unit comprises a wheel linkage, the handle linkage is affixed to the first gear, the wheel linkage is affixed to the third gear, the first gear is meshed to the second gear, and the second gear is meshed to the third gear, wherein in the auxiliary mode, when a pressing force is applied to the handle unit, the pressing force is transmitted to the gear set and pushes the second wheel unit, and the second wheel unit tends to move toward the first wheel unit. a walker body; a handle unit, connected to the walker body; a first wheel unit, connected to the walker body; a second wheel unit, connected to the walker body, wherein in an auxiliary mode, a first gap is formed between the first wheel unit and the second wheel unit, and in a driving mode, a second gap is formed between the first wheel unit and the second wheel unit, and the first gap is smaller than the second gap; and a gear set, wherein the gear set is connected to the walker body, the handle unit is directly connected to the gear set, and the second wheel unit is connected to the gear set, wherein the handle unit drives the gear set, wherein the gear set comprises a first gear, a second gear and a third gear, the handle unit comprises a handle linkage, the second wheel unit comprises a wheel linkage, the handle linkage is affixed to the first gear, the wheel linkage is affixed to the third gear, the first gear is meshed to the second gear, and the second gear is meshed to the third gear,
A measurement control method for minimization of drive test, MDT, in a user equipment, the method comprising the steps of: receiving measurement frequency information for cell reselection and measurement frequencies for MDT MDT Frequencies measuring a quality of a serving cell; performing a first quality measurement for a neighboring cell; performing a second quality measurement for the neighboring cell; and storing results of the first and second quality measurements, wherein the step of performing the first quality measurement includes performing intra-frequency measurement for the MDT for the neighboring cell when the frequency of the serving cell is included in the MDT frequencies, and performing the intra-frequency measurement for the neighboring cell only in the case where the quality of the serving cell is less than a first threshold value when the frequency of the serving cell is not included in the MDT frequencies, and the step of performing the second quality measurement includes performing intra-frequency measurement for the MDT for the neighboring cell when an inter-frequency in the measured frequency information for the cell reselection corresponds to the MDT frequencies, and performing inter-frequency measurement for the neighboring cell only in the case where the quality of the serving cell is less than a second threshold value when the inter-frequency in the measured frequency information for the cell reselection does not correspond to the MDT frequencies. receiving measurement frequency information for cell reselection and measurement frequencies for MDT MDT Frequencies measuring a quality of a serving cell; performing a first quality measurement for a neighboring cell; performing a second quality measurement for the neighboring cell; and storing results of the first and second quality measurements, wherein the step of performing the first quality measurement includes performing intra-frequency measurement for the MDT for the neighboring cell when the frequency of the serving cell is included in the MDT frequencies, and performing the intra-frequency measurement for the neighboring cell only in the case where the quality of the serving cell is less than a first threshold value when the frequency of the serving cell is not included in the MDT frequencies, and the step of performing the second quality measurement includes performing intra-frequency measurement for the MDT for the neighboring cell when an inter-frequency in the measured frequency information for the cell reselection corresponds to the MDT frequencies, and performing inter-frequency measurement for the neighboring cell only in the case where the quality of the serving cell is less than a second threshold value when the inter-frequency in the measured frequency information for the cell reselection does not correspond to the MDT frequencies.
Motor vehicle having an operator control device for controlling at least two different components (18, 20, 22) of the motor vehicle, wherein the operator control device to this end has a display device and is designed to display a graphical user interface (18', 20', 22') for each of the components (18, 20, 22) on the display device for the purpose of selecting and activating functions of the components (18, 20, 22), only one of the user interfaces (18', 20', 22') being active at a time, and wherein the operator control device has a detection device designed to optically capture a control gesture made by a user with one hand and to detect whether the user makes a single, predetermined change gesture with his hand, and, on detection of the change gesture, to transmit a change signal to the operator control device, characterized in that the operator control device is designed so as, on receiving the change signal, to cyclically change, in a predetermined order of change, from a currently active user interface to the next user interface in the order of change and to activate the latter user interface, and, before changing, to store a current menu position in a menu structure with menu entries and submenus of the currently active user interface, which is skipped to directly on fresh activation of the user interface.
A signaling system comprising: a printed circuit board; a first integrated circuit package disposed on the printed circuit board; a second integrated circuit package disposed on the printed circuit board; and a plurality of electric signal conductors suspended above the printed circuit board and extending between the first and second integrated circuit packages; characterised in that the electric signal conductors make up a direct connect cable which is an integral component of only one of the integrated circuit packages (501A,501B) or the electric signal conductors make up first and second direct connect cables that are integral components of the first and the second integrated circuit packages (501A,501B) correspondingly and which terminate in mid-span connectors directly connected to each other. a printed circuit board; a first integrated circuit package disposed on the printed circuit board; a second integrated circuit package disposed on the printed circuit board; and a plurality of electric signal conductors suspended above the printed circuit board and extending between the first and second integrated circuit packages; characterised in that the electric signal conductors make up a direct connect cable which is an integral component of only one of the integrated circuit packages (501A,501B) or the electric signal conductors make up first and second direct connect cables that are integral components of the first and the second integrated circuit packages (501A,501B) correspondingly and which terminate in mid-span connectors directly connected to each other.
An optical probe for medical applications designed to be able to be held in one hand, said probe comprising at least: - a first lighting source, called excitation lighting source, adapted to cause fluorescence radiation of predetermined substances; - a second visible lighting source, the first and the second source being designed to illuminate a common zone, called intervention zone; - a first photosensitive matrix sensor; - a second photosensitive matrix sensor; the first and second photosensitive matrix sensors being designed so that, when the probe is disposed at a predetermined distance from the intervention zone, the image in the fluorescence spectrum of said zone forms on the photosensitive surface of the first matrix sensor and the image in the visible spectrum of said zone forms on the photosensitive surface of the second matrix sensor, the second visible lighting source comprises a polarising filter, with an analyser then being disposed upstream of the second photosensitive matrix sensor, the polarisation direction of the analyser then being perpendicular to the polarisation direction of the polarising filter, characterised in that the first lighting source, called excitation lighting source, is a laser source, the spectral emission of which corresponds to the excitation spectrum, and in that the probe comprises means (80, 81) for measuring the incline of the optical probe and means for cutting off the laser source when the incline of the optical probe exceeds a predetermined value. - a first lighting source, called excitation lighting source, adapted to cause fluorescence radiation of predetermined substances; - a second visible lighting source, the first and the second source being designed to illuminate a common zone, called intervention zone; - a first photosensitive matrix sensor; - a second photosensitive matrix sensor;
A method of processing video data, the method comprising: receiving a bitstream representing a plurality of pictures including one or more clean random access pictures having a NAL unit type indicating a CRA picture with associated tagged for discard pictures, or one or more broken link access pictures having a NAL unit type indicating a BLA picture with associated TFD pictures, wherein the TFD pictures are non-decodable leading pictures; receiving, from an external means, a message which indicates whether the TFD pictures of at least one of the one or more CRA pictures or the one or more BLA pictures were discarded by the external means, and thus whether to use an alternative set of coded picture buffer parameters for the at least one of the one or more CRA pictures or the one or more the BLA pictures; setting a variable defined to indicate a set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures, based on the received message, such that the variable indicates the alternative set of CPB parameters when the TFD pictures were discarded by the external means; and selecting the alternative set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures when the variable indicates the alternative set of CPB parameters, or selecting a default set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures when the variable does not indicate the alternative set of CPB parameters. receiving a bitstream representing a plurality of pictures including one or more clean random access pictures having a NAL unit type indicating a CRA picture with associated tagged for discard pictures, or one or more broken link access pictures having a NAL unit type indicating a BLA picture with associated TFD pictures, wherein the TFD pictures are non-decodable leading pictures; receiving, from an external means, a message which indicates whether the TFD pictures of at least one of the one or more CRA pictures or the one or more BLA pictures were discarded by the external means, and thus whether to use an alternative set of coded picture buffer parameters for the at least one of the one or more CRA pictures or the one or more the BLA pictures; setting a variable defined to indicate a set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures, based on the received message, such that the variable indicates the alternative set of CPB parameters when the TFD pictures were discarded by the external means; and selecting the alternative set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures when the variable indicates the alternative set of CPB parameters, or selecting a default set of CPB parameters for the at least one of the one or more CRA pictures or the one or more BLA pictures when the variable does not indicate the alternative set of CPB parameters.
A waterborne base coat having a special-effect color and which contains aqueous microgel as binder, 0.5 to 2 wt.-% of poly(meth)acrylic acid thickener and 2 to 7 wt.-% of non-ionically emulsified EVA copolymer wax with a drop point of the wax portion of 80 to 100°C, to form an aqueous coating composition having a solids content of 15-25%, the wt.-% in each case calculated as solids and relative to the solids content of the waterborne base coat. 0.5 to 2 wt.-% of poly(meth)acrylic acid thickener and 2 to 7 wt.-% of non-ionically emulsified EVA copolymer wax with a drop point of the wax portion of 80 to 100°C,
An inverter-integrated electric compressor which incorporates a motor, an inverter section having a motor drive circuit to drive said motor and being provided with a control circuit board and electric component parts, wherein said control circuit board and said electric component parts are fixed in a housing space surrounded by a compressor housing, wherein said control circuit board is fixed through a board-fixing section in said housing space, wherein a board vibration-isolating member for board vibration-isolating, which is made of an electrically insulative elastic material, is provided so as to interpose between said control circuit board and said board-fixing section, and wherein said control circuit board is provided with an insertion hole in the form of a through-hole through which a part of said board vibration-isolating member is inserted so as to fix said board vibration-isolating member onto said control circuit board, characterized in that said board vibration-isolating member is provided with a neck part having a smaller diameter than the diameter of said insertion hole, a locking part having a greater diameter than the diameter of said insertion hole and a conical stopper part having a greater maximum diameter than the diameter of said insertion hole and a smaller minimum diameter than the diameter of said insertion hole, wherein the conical stopper part is elastically deformable and insertable into said insertion hole, and elastically restorable at the opposite side of the locking part as viewed from the control circuit board.
A method of rapidly constructing a high throughput sequencing library for detecting chromosome copy number variation, characterized in that, the method comprises the following steps: subjecting DNAs to be tested to random fragmentation by a double-strand DNA fragmentation enzyme; end-filling and adding poly-adenine at the 3' end of the fragmented DNAs; connecting the end-filled DNAs having a 3' end poly-adenine with sequencing linkers to obtain connected products; purifying the connected products to obtain the sequencing library; wherein steps - are performed in a single reaction tube; wherein the DNAs are as less as lOng; and wherein the method does not comprise a step of PCR amplification. subjecting DNAs to be tested to random fragmentation by a double-strand DNA fragmentation enzyme; end-filling and adding poly-adenine at the 3' end of the fragmented DNAs; connecting the end-filled DNAs having a 3' end poly-adenine with sequencing linkers to obtain connected products; purifying the connected products to obtain the sequencing library; wherein steps - are performed in a single reaction tube; wherein the DNAs are as less as lOng; and wherein the method does not comprise a step of PCR amplification. wherein steps - are performed in a single reaction tube; wherein the DNAs are as less as lOng; and wherein the method does not comprise a step of PCR amplification.