A body worn patient monitoring device comprising: at least one disposable electrode module including a flexible printed circuit board layer and an insulating/adhesive member providing a bottom cover for the flexible printed circuit board layer and augmenting adhesion to a human body, the disposable electrode module having a plurality of electrical connections, the electrical connections couplable to a skin surface at a bottom side of the disposable electrode module to measure physiological signals of a patient, the at least one disposable electrode module including a disposable module connector affixed to a top surface of the flexible circuit board layer; at least one internal or external power source to power the body worn patient monitoring device; and at least one removable and reusable communication-computation module having a communication-computation module connector to receive physiological signals from the at least one disposable electrode module via said disposable module connector, the removable and reusable communication-computation module including: a cover and a base; at least one microprocessor to actively monitor the patient and to perform a real-time physiological analysis of the physiological signals, and a radio circuit to communicate an unprocessed physiological signal or a result of the physiological analysis at a predetermined time or on the occurrence of a predetermined event, via a radio transmission to a remote radio receiver, wherein the at least one disposable electrode module is removably mechanically and electrically coupled directly to the at least one removable and reusable communication-computation module using the disposable module connector; and the body worn patient monitoring device including the at least one disposable electrode module and the at least one removable and reusable communication-computation module is directly non-permanently affixed to the skin surface of the patient. at least one disposable electrode module including a flexible printed circuit board layer and an insulating/adhesive member providing a bottom cover for the flexible printed circuit board layer and augmenting adhesion to a human body, the disposable electrode module having a plurality of electrical connections, the electrical connections couplable to a skin surface at a bottom side of the disposable electrode module to measure physiological signals of a patient, the at least one disposable electrode module including a disposable module connector affixed to a top surface of the flexible circuit board layer; at least one internal or external power source to power the body worn patient monitoring device; and at least one removable and reusable communication-computation module having a communication-computation module connector to receive physiological signals from the at least one disposable electrode module via said disposable module connector, the removable and reusable communication-computation module including: a cover and a base; at least one microprocessor to actively monitor the patient and to perform a real-time physiological analysis of the physiological signals, and a radio circuit to communicate an unprocessed physiological signal or a result of the physiological analysis at a predetermined time or on the occurrence of a predetermined event, via a radio transmission to a remote radio receiver, wherein the at least one disposable electrode module is removably mechanically and electrically coupled directly to the at least one removable and reusable communication-computation module using the disposable module connector; and the body worn patient monitoring device including the at least one disposable electrode module and the at least one removable and reusable communication-computation module is directly non-permanently affixed to the skin surface of the patient. a cover and a base; at least one microprocessor to actively monitor the patient and to perform a real-time physiological analysis of the physiological signals, and a radio circuit to communicate an unprocessed physiological signal or a result of the physiological analysis at a predetermined time or on the occurrence of a predetermined event, via a radio transmission to a remote radio receiver, wherein the at least one disposable electrode module is removably mechanically and electrically coupled directly to the at least one removable and reusable communication-computation module using the disposable module connector; and the body worn patient monitoring device including the at least one disposable electrode module and the at least one removable and reusable communication-computation module is directly non-permanently affixed to the skin surface of the patient.