Compounds of the formula I in which R denotes Ar, Het, -C=C-Ar or -C≡C-Het, W denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, CH 2 Cyc, Ar, CH 2 Ar, (C(R 3) 2] m NR 6 COA or (C(R 3) 2] m CR 3 (COOA)NR 6 COA, R 1 denotes A, R 2, R 2' each, independently of one another, denote H, A or [C(R 3) 2] n Cyc, R 3 denotes H or unbranched or branched alkyl with 1-6 C-atoms, R 4 denotes H, OA', Hal or A', X 1, X 2, X 3, X 4 each, independently of one another, denote CH or N, A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N- and/or O-atoms and wherein 1-7 H-atoms may be replaced by R 5, Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by A', A' denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F, R 5 denotes F or Cl, R 6 denotes H or A', Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, CN, CON(R 3) 2, [C(R 3) 2] p OA, [C(R 3) 2] p COOR 3, A, Cyc and/or OCH 2 Cyc, Het denotes furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzotriazolyl, indolyl, benzo-1,3-dioxolyl, benzodioxanyl, benzothiadiazolyl, indazolyl, benzofuranyl, quinolyl, isoquinolyl, oxazolo[5,4-b]pyridyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-a]pyridyl, oxazolo[5,4-c]pyridyl, 2,3-dihydro-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, tetrahydropyranyl, 2,3-dihydro-benzimidazolyl, pyrrolo[2,3-c]pyridyl, oxazolo[4,5-b]pyridyl, furo[3,2-b]pyridyl or pyrrolo[3,2-b]pyridyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, [C(R 3) 2] n OA', [C(R 3) 2] n N(R 3) 2, CON(R 3) 2, Het 1, A, [C(R 3) 2] n CN and/or =O, Het 1 denotes furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl or morpholinyl, each of which is unsubstituted or mono- or disubstituted by Hal, A and/or =O, Hal denotes F, Cl, Br or I, m denotes 1, 2 or 3, n denotes 0, 1 or 2, p denotes 0, 1, 2, 3 or 4, q denotes 0, 1, 2 or 3, with the proviso that only one or two of X 1, X 2, X 3, X 4 denote N, and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. R denotes Ar, Het, -C=C-Ar or -C≡C-Het, W denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, CH 2 Cyc, Ar, CH 2 Ar, (C(R 3) 2] m NR 6 COA or (C(R 3) 2] m CR 3 (COOA)NR 6 COA, R 1 denotes A, R 2, R 2' each, independently of one another, denote H, A or [C(R 3) 2] n Cyc, R 3 denotes H or unbranched or branched alkyl with 1-6 C-atoms, R 4 denotes H, OA', Hal or A', X 1, X 2, X 3, X 4 each, independently of one another, denote CH or N, A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N- and/or O-atoms and wherein 1-7 H-atoms may be replaced by R 5, Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by A', A' denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F, R 5 denotes F or Cl, R 6 denotes H or A', Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, CN, CON(R 3) 2, [C(R 3) 2] p OA, [C(R 3) 2] p COOR 3, A, Cyc and/or OCH 2 Cyc, Het denotes furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzotriazolyl, indolyl, benzo-1,3-dioxolyl, benzodioxanyl, benzothiadiazolyl, indazolyl, benzofuranyl, quinolyl, isoquinolyl, oxazolo[5,4-b]pyridyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-a]pyridyl, oxazolo[5,4-c]pyridyl, 2,3-dihydro-indolyl, 2,3-dihydro-benzo[1,4]dioxinyl, tetrahydropyranyl, 2,3-dihydro-benzimidazolyl, pyrrolo[2,3-c]pyridyl, oxazolo[4,5-b]pyridyl, furo[3,2-b]pyridyl or pyrrolo[3,2-b]pyridyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, [C(R 3) 2] n OA', [C(R 3) 2] n N(R 3) 2, CON(R 3) 2, Het 1, A, [C(R 3) 2] n CN and/or =O, Het 1 denotes furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl or morpholinyl, each of which is unsubstituted or mono- or disubstituted by Hal, A and/or =O, Hal denotes F, Cl, Br or I, m denotes 1, 2 or 3, n denotes 0, 1 or 2, p denotes 0, 1, 2, 3 or 4, q denotes 0, 1, 2 or 3,