mhurhangee/ep-ind-claims huggingface dataset:
A bispecific antibody comprising a) a first antibody that binds to a first antigen comprising a VH 1 domain and a VL 1 domain, wherein the VH 1 domain and the VL 1 domain are stabilized by a disulfide bridge, and b) a second antibody that binds to a second antigen, wherein the second antibody is a whole antibody, wherein the antibody comprises from C-to N-terminus the following polypeptide chains: - one VH 1 -peptide linker-CH3-CH2-CH1-VH 2 chain, - two CL-VL 2 chains, and - one VL 1 -peptide linker-CH3-CH2-CH1-VH 2 chain; wherein the first CH3 domain of the heavy chain of the whole antibody and the second CH3 domain of the whole antibody each meet at an interface which comprises an alteration in the original interface between the antibody CH3 domains; wherein i) in the CH3 domain of one heavy chain, an amino acid residue is replaced with an amino acid residue selected from the group consisting of arginine, phenylalanine, tyrosine, and tryptophan, thereby generating a protuberance within the interface of the CH3 domain of one heavy chain which is positionable in a cavity within the interface of the CH3 domain of the other heavy chain and ii) in the CH3 domain of the other heavy chain, an amino acid residue is replaced with an amino acid residue selected from the group consisting of alanine, serine, threonine, and valine, thereby generating a cavity within the interface of the second CH3 domain within which a protuberance within the interface of the first CH3 domain is positionable and characterized in that one of the linkers comprises a tumor- or inflammation-specific protease cleavage site, and the other linker does not comprise a protease cleavage site; and the binding affinity of the bispecific antibody to the first antigen is reduced 5 times or more compared to the corresponding bispecific antibody in which the protease cleavage site is cleaved. a) a first antibody that binds to a first antigen comprising a VH 1 domain and a VL 1 domain, wherein the VH 1 domain and the VL 1 domain are stabilized by a disulfide bridge, and b) a second antibody that binds to a second antigen, wherein the second antibody is a whole antibody, - one VH 1 -peptide linker-CH3-CH2-CH1-VH 2 chain, - two CL-VL 2 chains, and - one VL 1 -peptide linker-CH3-CH2-CH1-VH 2 chain; ii) in the CH3 domain of the other heavy chain, one of the linkers comprises a tumor- or inflammation-specific protease cleavage site, and the other linker does not comprise a protease cleavage site; and the binding affinity of the bispecific antibody to the first antigen is reduced 5 times or more compared to the corresponding bispecific antibody in which the protease cleavage site is cleaved.
A plastic article formed from a thermoplastic composition comprising a polycarbonate having repeating structural carbonate units according to the formula in which at least 60 percent of the total number of R 1 groups contain aromatic moieties and the balance thereof are aliphatic, alicyclic, or aromatic; the polycarbonate having been prepared through an interfacial polymerization process from BPA monomer having an organic purity higher than 99.70 % by weight and having a hydroxyl content lower than 150 ppm by weight; 0.01 wt.% to 0.30 wt.%, based on the total weight of the thermoplastic composition, of an epoxy additive having at least two epoxy groups per molecule; and 0.01 wt.% to 0.30 wt.%, based on the total weight of the thermoplastic composition, of a phenolic diphosphite derived from pentaerythritol; wherein the thermoplastic composition has a sulfur content lower than 2 ppm, and wherein the thermoplastic composition exhibits a dE (2000hrs.) value of less than 2.0 after 2000 hours of heat aging at 130°C, measured according ISO 11664-4:2008 /CIE S 014-4/E:2007 using CIE illuminant D65 and a 2.5 mm thick molded plaque of the thermoplastic composition.
A process of synthesizing an amide linked oligonucleotide conjugate comprising the step of reacting a conjugate group to a reactive amino group of an oligonucleotide, wherein said reaction step is performed in a solvent composition comprising at least about 85% (v/v) polar aprotic solvent, wherein the molar ratio of the conjugate group / oligonucleotide used in the solvent composition is between about 0.5 and about 2, and wherein the solvent composition comprises a lipophilic cation.
A method for uplink, UL, transmission in an unlicensed band, the method comprising: receiving, by a wireless device, an UL grant for the UL transmission in the unlicensed band from a base station, BS, wherein the UL grant comprises resource allocation of a physical uplink shared channel, PUSCH, and information on whether a PUSCH type is a truncated PUSCH whose last orthogonal frequency division multiplexing, OFDM, symbol is empty; and transmitting, by the wireless device, a PUSCH in a subframe in the unlicensed band based on the UL grant, wherein the subframe comprises a plurality of OFDM symbols. receiving, by a wireless device, an UL grant for the UL transmission in the unlicensed band from a base station, BS, wherein the UL grant comprises resource allocation of a physical uplink shared channel, PUSCH, and information on whether a PUSCH type is a truncated PUSCH whose last orthogonal frequency division multiplexing, OFDM, symbol is empty; and transmitting, by the wireless device, a PUSCH in a subframe in the unlicensed band based on the UL grant, wherein the subframe comprises a plurality of OFDM symbols.
Building element comprising of a block made of a fibrous material, and forming elements which are disposed on the surfaces of the block and comprise a pair of frames interconnected by at least one transverse brace to form a single structure, the building element also comprising a forming mesh, which is disposed between the fibrous material block and the frames on top of the transverse braces that connect the frames, outer and inner walls, which are fastened from the outer sides of the frames; and membranes, which are disposed above the frames between the walls and the frames characterized in that the mesh is also disposed above the fibrous material block in use, and the outer contour of the frames comprising curvilinear jigsaw-like locking elements.
A NAO friction material which is a non-asbestos-organic friction material utilized for a disc brake pad, which is manufactured by forming a non-asbestos organic friction material composition comprising a copper component of less than 5 weight % in total relative to the total amount of the friction material composition, characterized in that said friction material composition comprises 0.5 - 10 weight % of a graphitic carbon particle having a graphitization degree of 80-95 % according to the X-ray analysis relative to the total amount of the friction material composition as a carbon type lubricant, and 1-15 weight % of ferrous sulfide relative to the total amount of the friction material composition as a metal sulfide type lubricant.
A method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with a hydroperoxide in the presence of a catalytic effective amount of a crystalline MWW-type titanosilicate catalyst.
- A method for ensuring Mandatory Access Control in a virtual machine adapted for running object oriented programs and based on strongly typed language, by means of a mandatory access control module (Instr_module), said method comprising: - configuring the mandatory access control module (Instr_module) with an access policy (Acc_pol); - upon event reception indicating a method invocation (Meth_entry) or an access request to a variable member, adding an access control label (LabE, LabR) to the object calling the method (Meth) or requesting the access, named "caller" (CalR), and the object called by the method (Meth) or whose access is requested, named "callee" (CalE), according to the caller and callee language types (Typ_CalR, Typ_CalE); - making a decision (Dec) of blocking the execution of the method (Meth) or the access to the variable member, named "negative decision", or a decision (Dec) of letting the virtual machine run the method (Meth) or access the variable member, named "positive decision", according to said access control labels (LabE, LabR), the instance numbers of the caller and the callee (Inst_Num), the access policy (Acc_pol), and the access permissions; - transmitting said decision (Dec) to the virtual machine for blocking or granting the corresponding access attempt. - configuring the mandatory access control module (Instr_module) with an access policy (Acc_pol); - upon event reception indicating a method invocation (Meth_entry) or an access request to a variable member, adding an access control label (LabE, LabR) to the object calling the method (Meth) or requesting the access, named "caller" (CalR), and the object called by the method (Meth) or whose access is requested, named "callee" (CalE), according to the caller and callee language types (Typ_CalR, Typ_CalE); - making a decision (Dec) of blocking the execution of the method (Meth) or the access to the variable member, named "negative decision", or a decision (Dec) of letting the virtual machine run the method (Meth) or access the variable member, named "positive decision", according to said access control labels (LabE, LabR), the instance numbers of the caller and the callee (Inst_Num), the access policy (Acc_pol), and the access permissions; - transmitting said decision (Dec) to the virtual machine for blocking or granting the corresponding access attempt.
A file storage method, applied to a terminal, characterized by comprising: obtaining a to-be-stored file, and performing splitting processing on the to-be-stored file to obtain N sub-files corresponding to the to-be-stored file, wherein N is an integer greater than 1; sending the N sub-files to an InterPlanetary File System, IPFS, and receiving M pieces of address information corresponding to the N sub-files returned by the IPFS, wherein M is an integer greater than 1 and less than or equal to N; generating an address set corresponding to the to-be-stored file according to the M pieces of address information, and encrypting the address set to obtain an address set ciphertext; and sending the address set ciphertext to a blockchain network and receiving a target index value returned by the blockchain network, wherein the target index value is used to identify the address set ciphertext. obtaining a to-be-stored file, and performing splitting processing on the to-be-stored file to obtain N sub-files corresponding to the to-be-stored file, wherein N is an integer greater than 1; sending the N sub-files to an InterPlanetary File System, IPFS, and receiving M pieces of address information corresponding to the N sub-files returned by the IPFS, wherein M is an integer greater than 1 and less than or equal to N; generating an address set corresponding to the to-be-stored file according to the M pieces of address information, and encrypting the address set to obtain an address set ciphertext; and sending the address set ciphertext to a blockchain network and receiving a target index value returned by the blockchain network, wherein the target index value is used to identify the address set ciphertext.
A subsea apparatus for scanning a subsea structure to detect changes in density between different parts of the structure, the apparatus comprising: a source of radiation; and a plurality of detectors, each of the detectors comprising: a scintillator comprising a scintillating material for emitting light in response to incident radiation from the source, and a photodetector for receiving light emitted by the scintillating material and outputting an electrical signal in response to light received from the scintillating material, characterized in that the photodetector of each detector comprises a plurality of silicon photomultipliers and wherein the apparatus is configured such that current output signals of said plurality of silicon photomultipliers are combined in parallel prior to amplification. a source of radiation; and a plurality of detectors, each of the detectors comprising: a scintillator comprising a scintillating material for emitting light in response to incident radiation from the source, and a photodetector for receiving light emitted by the scintillating material and outputting an electrical signal in response to light received from the scintillating material, a scintillator comprising a scintillating material for emitting light in response to incident radiation from the source, and a photodetector for receiving light emitted by the scintillating material and outputting an electrical signal in response to light received from the scintillating material, characterized in that the photodetector of each detector comprises a plurality of silicon photomultipliers and wherein the apparatus is configured such that current output signals of said plurality of silicon photomultipliers are combined in parallel prior to amplification.
Apparatus for winding up web-like materials into rolls (42, 48), comprising two frame arrangements (10, 11) movably arranged at a framework and each comprising a pair (2, 3) of carrier rollers (4, 5; 6, 7) arranged adjacent to each other, characterised in that holding elements are provided at the framework with which the arrangement (10, 11) is fixed at the framework before the web-like material is separated by means of a cross cutting device.
A drive connection (20; 120) configured to be interconnected between a main driving unit and a main gear unit (40; 140) of a driving device (14, 16) configured to drive a chain of a conveyor (4, 12) of a longwall device, the drive connection (20; 120) comprising: a housing (22; 122) configured to be connected to the main driving unit and to the main gear unit (40; 140); and a drive shaft (24; 124) disposed within the housing (22; 122) and configured to transmit torque from the main driving unit to the main gear unit (40; 140); characterized in that a chain tensioning apparatus (60; 160) is disposed within the housing (22; 122) and including a worm drive interacting with the drive shaft (24; 124), the chain tensioning apparatus (60; 160) being configured to, when the main driving unit is in a non-operative state, drive the drive shaft (24; 124) for tensioning the chain of the conveyor (4, 12). a housing (22; 122) configured to be connected to the main driving unit and to the main gear unit (40; 140); and a drive shaft (24; 124) disposed within the housing (22; 122) and configured to transmit torque from the main driving unit to the main gear unit (40; 140); characterized in that a chain tensioning apparatus (60; 160) is disposed within the housing (22; 122) and including a worm drive interacting with the drive shaft (24; 124), the chain tensioning apparatus (60; 160) being configured to, when the main driving unit is in a non-operative state, drive the drive shaft (24; 124) for tensioning the chain of the conveyor (4, 12).
A user equipment, UE, for wireless communication, comprising: a memory; and one or more processors, coupled to the memory, configured to: detect an occurrence of a triggering event associated with power headroom reporting, the triggering event corresponding to one or more uplink component carriers of the UE that are associated with one or more control resource set, CORESET, pool index values, wherein the one or more CORESET pool index values are each associated with a different transmit receive point, TRP; and transmit, from the UE to a base station, a power headroom report, PHR, medium access control, MAC, control element, CE, based at least in part on the occurrence of the triggering event, wherein the PHR MAC-CE is for one or more uplink component carriers of the UE, and wherein a maximum size of the PHR MAC-CE is based at least in part on a number of uplink component carriers that are configured with two CORESET pool index values. a memory; and one or more processors, coupled to the memory, configured to: detect an occurrence of a triggering event associated with power headroom reporting, the triggering event corresponding to one or more uplink component carriers of the UE that are associated with one or more control resource set, CORESET, pool index values, wherein the one or more CORESET pool index values are each associated with a different transmit receive point, TRP; and transmit, from the UE to a base station, a power headroom report, PHR, medium access control, MAC, control element, CE, based at least in part on the occurrence of the triggering event, wherein the PHR MAC-CE is for one or more uplink component carriers of the UE, and wherein a maximum size of the PHR MAC-CE is based at least in part on a number of uplink component carriers that are configured with two CORESET pool index values. detect an occurrence of a triggering event associated with power headroom reporting, the triggering event corresponding to one or more uplink component carriers of the UE that are associated with one or more control resource set, CORESET, pool index values, wherein the one or more CORESET pool index values are each associated with a different transmit receive point, TRP; and transmit, from the UE to a base station, a power headroom report, PHR, medium access control, MAC, control element, CE, based at least in part on the occurrence of the triggering event, wherein the PHR MAC-CE is for one or more uplink component carriers of the UE, and wherein a maximum size of the PHR MAC-CE is based at least in part on a number of uplink component carriers that are configured with two CORESET pool index values.
A clothes airer comprising two connecting members and four frame elements (41, 42, 46, 47) connected by the connecting members, wherein each connecting member comprises a core section having a width and two supporting members (43, 49) for supporting the frame elements (41, 47) extending in different directions from the connecting member, wherein each connecting member has two additional supporting members (44, 48) for supporting the frame elements (42, 46), each additional supporting member (44, 48) being pivotally connected to the core section and independently moveable between a first position and a second position in which the frame elements (42, 46) supported by the additional supporting members (44, 48) extend in a direction generally perpendicular to the frame elements (41, 47) supported by the supporting members (43, 49) of the core section, characterized in that in the first position the additional supporting members lie within the width of the core section and wherein two of the frame elements (41, 42) are fixed to supporting members (43, 44) at the same end of each connecting member and the other two frame elements (46, 47) are releasably attached to supporting members (48, 49) at the opposite end of each connecting member.
A capability matching method, performed by a user equipment, UE, comprising: before initiating a random access process, determining that the network side device is a network side device that does not support low cost machine type communication, LC-MTC, if any one of the following is met in received scheduling information: a resource block scheduled by the scheduling information is greater than 1000 bits; a downlink resource scheduled by the scheduling information is greater than a 1.4 MHz bandwidth; and a quantity of layers scheduled by the scheduling information is greater than 1; and reselecting to access another network side device. a resource block scheduled by the scheduling information is greater than 1000 bits; a downlink resource scheduled by the scheduling information is greater than a 1.4 MHz bandwidth; and a quantity of layers scheduled by the scheduling information is greater than 1; and reselecting to access another network side device.
An agricultural seeding implement having: a mobile frame that includes a main section, a left wing section and a right wing section, wherein the wing sections (25, 26) are hingedly attached to the main section, whereby the main section includes ground-engaging main section wheels (18a-18f) and the wing sections (25, 26) include ground-engageable wing section wheels (18g-18i, 18j-18l); a hydraulic operating circuit including a pair of hydraulic cylinders (158, 160) configured for applying adjustable down-pressure against the wing sections (25, 26); a seed hopper located on the main section for dispensing seeds as the frame is advanced; and characterized by the hydraulic cylinders (158, 160) connected to and between the wing sections (25, 26), a pressure transducer connected to the hydraulic cylinders (158, 160) configured to determine the down-pressure in the hydraulic cylinders (158, 160), a set of load cells (120, 122, 124) mounting the hopper on the main section of the frame configured to determine the weight of the hopper during field operations, an electrical control circuit connected to the pressure transducer and to the load cells (120, 122, 124) configured to perform a control function on the implement of adjusting hydraulic down pressure on the wing section (25, 26) based on a comparison of a value for the weight of the hopper with a value for the hydraulic down pressure on the wing section (25, 26). a mobile frame that includes a main section, a left wing section and a right wing section, wherein the wing sections (25, 26) are hingedly attached to the main section, whereby the main section includes ground-engaging main section wheels (18a-18f) and the wing sections (25, 26) include ground-engageable wing section wheels (18g-18i, 18j-18l); a hydraulic operating circuit including a pair of hydraulic cylinders (158, 160) configured for applying adjustable down-pressure against the wing sections (25, 26); a seed hopper located on the main section for dispensing seeds as the frame is advanced; and the hydraulic cylinders (158, 160) connected to and between the wing sections (25, 26), a pressure transducer connected to the hydraulic cylinders (158, 160) configured to determine the down-pressure in the hydraulic cylinders (158, 160), a set of load cells (120, 122, 124) mounting the hopper on the main section of the frame configured to determine the weight of the hopper during field operations, an electrical control circuit connected to the pressure transducer and to the load cells (120, 122, 124) configured to perform a control function on the implement of adjusting hydraulic down pressure on the wing section (25, 26) based on a comparison of a value for the weight of the hopper with a value for the hydraulic down pressure on the wing section (25, 26).
A method, comprising: computing an activity map for an input image, wherein the activity map indicates an amount of spatial activity in the input image and wherein computing the activity map comprises computing weighted entropy values on a pixel-by-pixel basis; producing an output image based on the activity map, said output image containing a plurality of color pixels, each color pixel represented by at least one of cyan, magenta, yellow, and black in a color space, wherein producing the output image comprises determining target black values for each pixel based on default black values of the input image for the pixel and the computed entropy value for the pixel so as to augment black levels in areas of high activity; and controlling a printhead to cause the output image to be printed. computing an activity map for an input image, wherein the activity map indicates an amount of spatial activity in the input image and wherein computing the activity map comprises computing weighted entropy values on a pixel-by-pixel basis; producing an output image based on the activity map, said output image containing a plurality of color pixels, each color pixel represented by at least one of cyan, magenta, yellow, and black in a color space, wherein producing the output image comprises determining target black values for each pixel based on default black values of the input image for the pixel and the computed entropy value for the pixel so as to augment black levels in areas of high activity; and controlling a printhead to cause the output image to be printed.