A vascular closure device comprising: a release tube (46, 48) having a release tube (46, 48) body that is elongate along a longitudinal direction, the release tube (46, 48) defining a distal end, a proximal end, and a release tube (46, 48) channel that extends from the distal end toward the proximal end along the longitudinal direction; a delivery tube disposed within the release tube (46, 48) channel such that at least one of the release tube (46, 48) and delivery tube is movable relative to the other, the delivery tube including a delivery tube body and defining a delivery channel that extends into the delivery tube body along the longitudinal direction; a drag member; a tensioner that contains the drag member; and a sealing assembly having a toggle that is at least partially disposed within the release tube (46, 48), a suture that is attached to the toggle and extends through the delivery channel and into the drag member such that the drag member applies a frictional force against the suture, the suture extending into the tensioner and through the drag member, and a plug that is attached to the suture relative to the toggle in a proximal direction that extends from the distal end toward the proximal end; characterized in that the vascular closure device further comprises: at least one actuator, wherein the at least one of the release tube (46, 48) and delivery tube is movable relative to the other upon actuation of the at least one actuator, wherein actuation of the at least one actuator moves at least one of the delivery tube and release tube (46, 48) relative to the other to thereby release the toggle and apply a tensional force to the suture, wherein the at least one actuator is coupled to the release tube (46, 48) and is in communication with the suture such that actuation of the at least one actuator causes (i) the release tube (46, 48) to move in the proximal direction relative to the delivery tube so as to release the toggle from the release tube (46, 48), and (ii) the suture to be pulled in the proximal direction to thereby urge the toggle against a distal end of the delivery tube such that the toggle is oriented in a sealing position.. a release tube (46, 48) having a release tube (46, 48) body that is elongate along a longitudinal direction, the release tube (46, 48) defining a distal end, a proximal end, and a release tube (46, 48) channel that extends from the distal end toward the proximal end along the longitudinal direction; a delivery tube disposed within the release tube (46, 48) channel such that at least one of the release tube (46, 48) and delivery tube is movable relative to the other, the delivery tube including a delivery tube body and defining a delivery channel that extends into the delivery tube body along the longitudinal direction; a drag member; a tensioner that contains the drag member; and a sealing assembly having a toggle that is at least partially disposed within the release tube (46, 48), a suture that is attached to the toggle and extends through the delivery channel and into the drag member such that the drag member applies a frictional force against the suture, the suture extending into the tensioner and through the drag member, and a plug that is attached to the suture relative to the toggle in a proximal direction that extends from the distal end toward the proximal end; characterized in that the vascular closure device further comprises: at least one actuator, wherein the at least one of the release tube (46, 48) and delivery tube is movable relative to the other upon actuation of the at least one actuator, wherein actuation of the at least one actuator moves at least one of the delivery tube and release tube (46, 48) relative to the other to thereby release the toggle and apply a tensional force to the suture, wherein the at least one actuator is coupled to the release tube (46, 48) and is in communication with the suture such that actuation of the at least one actuator causes (i) the release tube (46, 48) to move in the proximal direction relative to the delivery tube so as to release the toggle from the release tube (46, 48), and (ii) the suture to be pulled in the proximal direction to thereby urge the toggle against a distal end of the delivery tube such that the toggle is oriented in a sealing position.. at least one actuator, wherein the at least one of the release tube (46, 48) and delivery tube is movable relative to the other upon actuation of the at least one actuator, wherein actuation of the at least one actuator moves at least one of the delivery tube and release tube (46, 48) relative to the other to thereby release the toggle and apply a tensional force to the suture, wherein the at least one actuator is coupled to the release tube (46, 48) and is in communication with the suture such that actuation of the at least one actuator causes (i) the release tube (46, 48) to move in the proximal direction relative to the delivery tube so as to release the toggle from the release tube (46, 48), and (ii) the suture to be pulled in the proximal direction to thereby urge the toggle against a distal end of the delivery tube such that the toggle is oriented in a sealing position..