A compound that has the following structure of Formula (IIa): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 and Z 2 are independently selected from -O-, -(CH 2)-, -C -, or a bond; Cy is C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, C 2 -C 20 heterocyclyl, or C 1 -C 20 heteroaryl; X is -(CH 2)-; R 1 is selected from H, F, Cl, -CN, -CH 2 OH, -CH(CH 3)OH, -C(CH 3) 2 OH,-CH(CF 3)OH, -CH 2 F, -CHF 2, -CH 2 CHF 2, -CF 3, -CH 3, -C NH 2, -C NHCH 3, and-C N(CH 3) 2; each R 2 and each R 3 are independently selected from halogen, -CN, -OR 10, -NR 13 R 14, C 1 -C 4 alkyl, -C 1 -C 4 alkyl-OH, -OC 2 -C 4 alkyl-OH, C 1 -C 4 fluoroalkyl, -C(=O)OR 12,-NHC(=O)R 11, -C(=O)NHR 12, -SO 2 R 11, -NHSO 2 R 11, and -SO 2 NHR 12; R 6 is selected from H, halogen, C 1 -C 6 alkyl and C 1 -C 6 fluoroalkyl; each R 10 is independently selected from H, C 1 -C 4 alkyl, and C 1 -C 4 fluoroalkyl; each R 11 is independently selected from C 1 -C 4 alkyl and C 1 -C 4 fluoroalkyl; each R 12 is independently selected from H, C 1 -C 4 alkyl, and C 1 -C 4 fluoroalkyl; each R 13 and each R 14 are independently selected from H and C 1 -C 4 alkyl; m is 0, 1, 2 or 3; and n is 0, 1, 2 or 3; where carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CH 3, -CH 2 CH 3,-CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH,-CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F, -CHF 2,-CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN, -CH 2 CN, -CO 2 H, -COCH 3,-CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2,-C(CH 3) 2 CONH 2, -NH 2, -NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3,-OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OCF 3, -OCHF 2, -OP 2,-S 2 N(CH 3) 2, -SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, pyrrolidin-1-yl, and morpholino. Z 1 and Z 2 are independently selected from -O-, -(CH 2)-, -C -, or a bond; Cy is C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, C 2 -C 20 heterocyclyl, or C 1 -C 20 heteroaryl; X is -(CH 2)-; R 1 is selected from H, F, Cl, -CN, -CH 2 OH, -CH(CH 3)OH, -C(CH 3) 2 OH,-CH(CF 3)OH, -CH 2 F, -CHF 2, -CH 2 CHF 2, -CF 3, -CH 3, -C NH 2, -C NHCH 3, and-C N(CH 3) 2; each R 2 and each R 3 are independently selected from halogen, -CN, -OR 10, -NR 13 R 14, C 1 -C 4 alkyl, -C 1 -C 4 alkyl-OH, -OC 2 -C 4 alkyl-OH, C 1 -C 4 fluoroalkyl, -C(=O)OR 12,-NHC(=O)R 11, -C(=O)NHR 12, -SO 2 R 11, -NHSO 2 R 11, and -SO 2 NHR 12; R 6 is selected from H, halogen, C 1 -C 6 alkyl and C 1 -C 6 fluoroalkyl; each R 10 is independently selected from H, C 1 -C 4 alkyl, and C 1 -C 4 fluoroalkyl; each R 11 is independently selected from C 1 -C 4 alkyl and C 1 -C 4 fluoroalkyl; each R 12 is independently selected from H, C 1 -C 4 alkyl, and C 1 -C 4 fluoroalkyl; each R 13 and each R 14 are independently selected from H and C 1 -C 4 alkyl; m is 0, 1, 2 or 3; and n is 0, 1, 2 or 3; where carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CH 3, -CH 2 CH 3,-CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH,-CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F, -CHF 2,-CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN, -CH 2 CN, -CO 2 H, -COCH 3,-CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2,-C(CH 3) 2 CONH 2, -NH 2, -NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3,-OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OCF 3, -OCHF 2, -OP 2,-S 2 N(CH 3) 2, -SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, pyrrolidin-1-yl, and morpholino.