mhurhangee/ep-ind-claims huggingface dataset:
A syringe arrangement - comprising a syringe having a syringe needle and a measuring system for finding a suitable puncture point for a needle into a body, with - at least one measurement probe as a first electrode, - with at least one counter-electrode and - with at least one voltage detector with which it can be determined whether the voltage in effect between the measurement probe and the counter-electrode is below a pre-defined limit, and - comprising a clamping device, wherein the measurement probe is attached to the syringe by means of the clamping device, - wherein the measurement probe is slideably mounted relative to the syringe needle. - comprising a syringe having a syringe needle and a measuring system for finding a suitable puncture point for a needle into a body, with - at least one measurement probe as a first electrode, - with at least one counter-electrode and - with at least one voltage detector with which it can be determined whether the voltage in effect between the measurement probe and the counter-electrode is below a pre-defined limit, and - comprising a clamping device, wherein the measurement probe is attached to the syringe by means of the clamping device, - wherein the measurement probe is slideably mounted relative to the syringe needle.
A universal joint jaw (12A, 12B) made in a single piece and comprising: - a base (12.1) having a cavity (12.2) for housing a shaft end, the cavity (12.2) defining a geometric insertion axis (100A, 100B) for a shaft end, the cavity (12.2) having a constant section between two open axial ends, a geometric envelope of the cavity being defined by a generatrix parallel to the geometric insertion axis and describing the constant section of the cavity (12.2) of the base, and - two side wings (12.5) connected to the base (12.1), the two wings (12.5) facing one another and delimiting a volume (24A, 24B) between them for receiving a universal joint journal cross (20A, 20B), the two wings (12.5) each being provided with a guide bearing housing (12.6) for the universal joint journal cross (20A, 20B), the two housings (12.6) defining a pivot axis of the journal cross, perpendicular to the geometric insertion axis, - a connecting bridge (12.7) connecting the two side wings (12.5), the two bearing housings (12.6) being situated between the base (12.1) and the connecting bridge (12.7) in reference to the insertion axis, characterized in that the connecting bridge (12.7) comprises a through hole (12.8) coaxial with the insertion axis, the through hole (12.8) having a section situated in all points radially outside, or coinciding with, the geometric envelope of the cavity of the base. - a base (12.1) having a cavity (12.2) for housing a shaft end, the cavity (12.2) defining a geometric insertion axis (100A, 100B) for a shaft end, the cavity (12.2) having a constant section between two open axial ends, a geometric envelope of the cavity being defined by a generatrix parallel to the geometric insertion axis and describing the constant section of the cavity (12.2) of the base, and - two side wings (12.5) connected to the base (12.1), the two wings (12.5) facing one another and delimiting a volume (24A, 24B) between them for receiving a universal joint journal cross (20A, 20B), the two wings (12.5) each being provided with a guide bearing housing (12.6) for the universal joint journal cross (20A, 20B), the two housings (12.6) defining a pivot axis of the journal cross, perpendicular to the geometric insertion axis, - a connecting bridge (12.7) connecting the two side wings (12.5), the two bearing housings (12.6) being situated between the base (12.1) and the connecting bridge (12.7) in reference to the insertion axis,
Water-conducting household appliance, with: - a water container with a treatment chamber therein, the water container having a drain at the bottom, - a pump, - a filter between the drain and the pump, - a water supply with water pipes (52, 54, 58), valves (35, 66), the pump and the filter, whereby - a flexible or bendable flexible line connects to the drain and runs downwards from the drain at an angle between 15° and 0° to the vertical, characterized in that - a length-adjustable telescopic line connects to the flexible line and leads to the filter, the telescopic line running at an angle of between 0° and 20° to the horizontal, - a drain valve is arranged between the telescopic line and the filter, - the filter is arranged downstream of the drain valve, - the telescopic line is designed to comprise a plurality of individual lines (62, 64), - the individual lines (62, 64) are designed to be rigid in themselves and have different diameters in order to form the telescopic line when inserted into one another, for the purpose of changing its length. - a water container with a treatment chamber therein, the water container having a drain at the bottom, - a pump, - a filter between the drain and the pump, - a water supply with water pipes (52, 54, 58), valves (35, 66), the pump and the filter, - a flexible or bendable flexible line connects to the drain and runs downwards from the drain at an angle between 15° and 0° to the vertical, - a length-adjustable telescopic line connects to the flexible line and leads to the filter, the telescopic line running at an angle of between 0° and 20° to the horizontal, - a drain valve is arranged between the telescopic line and the filter, - the filter is arranged downstream of the drain valve, - the telescopic line is designed to comprise a plurality of individual lines (62, 64), - the individual lines (62, 64) are designed to be rigid in themselves and have different diameters in order to form the telescopic line when inserted into one another, for the purpose of changing its length.
A process for the start-up of a hydrodesulfurization section, comprising the steps of - providing a natural gas feed, - passing the natural gas feed through the waste heat section of a reformer, thereby heating the natural gas feed, - passing the heated natural gas feed through a hydrodesulfurization section comprising a hydrogenation part, thereby heating the hydrodesulfurization section while producing a desulfurized natural gas stream, and - providing a part of the desulfurized natural gas stream as fuel for the reformer, wherein sulfur-containing NG is constantly sent to the hydrogenator and recycling the remainder of the desulfurized natural gas to at least one point upstream the waste heat section. - providing a natural gas feed, - passing the natural gas feed through the waste heat section of a reformer, thereby heating the natural gas feed, - passing the heated natural gas feed through a hydrodesulfurization section comprising a hydrogenation part, thereby heating the hydrodesulfurization section while producing a desulfurized natural gas stream, and - providing a part of the desulfurized natural gas stream as fuel for the reformer,
A compound of formula or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein R 1A is hydrogen, R 1B is an acyl, or acyloxy group, R 2 is C 1-6 alkyl, arylalkyl or heteroarylalkyl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, di-(C 1-6)alkylamino, C 1-6 alkylamino, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, bicyclic heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl, or nitrile and R 3 is a C 1-8 alkyl, or arylalkyl each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C 1-6 alkyl, di-(C 1-6)alkylamino, C 1-6 alkylamino, C 1-6 alkoxy, C 3-6 cycloalkyl, carboxylic acid, aromatic or aliphatic carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl, or nitrile, R 1A is hydrogen, R 1B is an acyl, or acyloxy group, R 2 is C 1-6 alkyl, arylalkyl or heteroarylalkyl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, di-(C 1-6)alkylamino, C 1-6 alkylamino, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, bicyclic heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl, or nitrile and R 3 is a C 1-8 alkyl, or arylalkyl each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C 1-6 alkyl, di-(C 1-6)alkylamino, C 1-6 alkylamino, C 1-6 alkoxy, C 3-6 cycloalkyl, carboxylic acid, aromatic or aliphatic carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl, or nitrile,
A method of identifying an inhibitor of a protein modifying enzyme suitable for treating a patient, comprising: (i) calculating the value K for each protein modifying enzyme in a sample obtained from said patient using a method of quantifying the activity of a protein modifying enzyme in a sample, comprising inputting quantitative Mass Spectrometry phosphoproteomics data and calculating the value K for said protein-modifying enzyme as follows: K = ∑ i = 1 m α i ∑ j = 1 l β j wherein m = the number of modified peptides in the sample that are substrates of said protein modifying enzyme; α = the intensity of the modified peptides i; i = each modified peptide in the sample that is a substrate of said protein modifying enzyme; l = the total number of modified peptides in the sample; β = the intensity of the modified peptides j; and j = all of the modified peptides in the sample; (ii) identifying the protein modifying enzyme with the highest value K; and (iii) selecting an inhibitor that targets the protein modifying enzyme with the highest value K, wherein the protein modifying enzyme is a protein kinase and the patient is suffering from or suspected of suffering from cancer. (i) calculating the value K for each protein modifying enzyme in a sample obtained from said patient using a method of quantifying the activity of a protein modifying enzyme in a sample, comprising inputting quantitative Mass Spectrometry phosphoproteomics data and calculating the value K for said protein-modifying enzyme as follows: K = ∑ i = 1 m α i ∑ j = 1 l β j wherein m = the number of modified peptides in the sample that are substrates of said protein modifying enzyme; α = the intensity of the modified peptides i; i = each modified peptide in the sample that is a substrate of said protein modifying enzyme; l = the total number of modified peptides in the sample; β = the intensity of the modified peptides j; and j = all of the modified peptides in the sample; m = the number of modified peptides in the sample that are substrates of said protein modifying enzyme; α = the intensity of the modified peptides i; i = each modified peptide in the sample that is a substrate of said protein modifying enzyme; l = the total number of modified peptides in the sample; β = the intensity of the modified peptides j; and j = all of the modified peptides in the sample; (ii) identifying the protein modifying enzyme with the highest value K; and (iii) selecting an inhibitor that targets the protein modifying enzyme with the highest value K,
An extracellular-targeted drug conjugate comprising a targeting moiety linked by a stable or non-cleavable linker to an agent, wherein the targeting moiety binds to CD38, wherein the agent binds to or modifies the activity of a Na,K-ATPase.
A hair dye comprising 0.1 to 3.0 % by weight of at least one of aqueous acid dyes and a resin comprising a terpolymer constituted from vinyl pyrrolidone, dimethylaminopropylacrylamide and a quaternary derivative of dimethylaminopropylacrylamide represented by following Formula, wherein a content of the resin is 0.1 to 2.5 % by weight in terms of a solid content; and the hair dye further comprises 1.0 to 20 % by weight of a hair dyeing auxiliary agent which is at least one selected from benzyl alcohol, phenetyl alcohol, furfuryl alcohol, cyclohexanol, etylene glycol, propylene glycol, 1,3 - butylene glycol, glycerin, diglycerin, dipropylene glycol, methyl cellosolve, ethyl cellosolve, butyl cellosolve, methyl carbitol, ethyl carbitol, propyl carbitol, butyl carbitol, ethylene carbonate, propylene carbonate, butylene carbonate, N-methylpyrrolidone, N-ethylpyrrolidone, N-octylpyrrolidone and γ-butyrolactone, 20 to 60 % by weight of at least one lower alcohol selected from ethanol, propanol, butanol, isopropanol and isobutanol and 20 to 60 % by weight of water and has a pH of 2 to 4: (in Formula, P is NH; R 1 is a hydrogen atom, R 3 and R 4 each are a methyl group, R 5 represents propylene group; R 6 is an alkyl group having 12 to 18 carbon atoms; and M represents a halide, tosylate or phosphoric acid anion).
An apparatus for plasma etching, comprising: a process chamber; a support pedestal disposed in the process chamber and configured to receive a photomask thereon; an RF power source for forming a plasma within the chamber; and a shield disposed in the chamber above the pedestal, the shield comprising a substantially flat plate having a plurality of apertures and configured to control the distribution of charged and neutral species passing through the plate, wherein the plate comprises two adjacent zones (172A-172F), each zone having apertures and having at least one characteristic different from each other, the at least one characteristic being the material, wherein each of the two separate zones comprises a material with a dielectric constant different from each other, the material being selected from the group consisting of anodized aluminum, ceramics, alumina, yttria, materials having a dielectric constant higher than about 4. a process chamber; a support pedestal disposed in the process chamber and configured to receive a photomask thereon; an RF power source for forming a plasma within the chamber; and a shield disposed in the chamber above the pedestal, the shield comprising a substantially flat plate having a plurality of apertures and configured to control the distribution of charged and neutral species passing through the plate, wherein the plate comprises two adjacent zones (172A-172F), each zone having apertures and having at least one characteristic different from each other, the at least one characteristic being the material, wherein each of the two separate zones comprises a material with a dielectric constant different from each other, the material being selected from the group consisting of anodized aluminum, ceramics, alumina, yttria, materials having a dielectric constant higher than about 4.
Rear spoiler device for a vehicle having at least one rear door, wherein the rear spoiler device has an air guiding element for fitting to a lateral rear region of a vehicle: wherein the air guiding element can be pivoted between a travel position for contour extension and aerodynamic air guiding when the rear door is closed and a folded-in position when the rear door is open, wherein the air guiding element can be received in a hinge of the rear door, and characterized in that the rear spoiler device has a resilient device which presses the air guiding element in the travel position thereof against a counter-stop which is formed on the hinge, wherein the air guiding element has a bearing receiving member for pivotable bearing in a bearing pin of the hinge, which pin forms the pivot axis of the hinge, wherein the resilient device is constructed as a rotary spring for bearing in the bearing pin of the hinge. wherein the air guiding element can be pivoted between a travel position for contour extension and aerodynamic air guiding when the rear door is closed and a folded-in position when the rear door is open, wherein the air guiding element can be received in a hinge of the rear door, and characterized in that the rear spoiler device has a resilient device which presses the air guiding element in the travel position thereof against a counter-stop which is formed on the hinge, wherein the air guiding element has a bearing receiving member for pivotable bearing in a bearing pin of the hinge, which pin forms the pivot axis of the hinge, wherein the resilient device is constructed as a rotary spring for bearing in the bearing pin of the hinge.
Implantation device for a valve comprising: (a) a carrier element configured to carry artificial valves and configured to be able to be deployed from a collapsed configuration to a deployed configuration; and (b) a catheter assembly (3, 41, 42, 60) configured to hold the implantation device in a collapsed configuration when moving to a position upstream of the final targeted position; characterised in that the implantation device further comprises: (c) at least one feeler element (30, 31) extending from the carrier element, the carrier element and the feeler elements (30, 31) being disposed so that natural valves can be pinched between the carrier element and the feeler elements (30, 31); while said at least one feeler element (30, 31) is deformable and is arranged to change from a collapsed form to an operational deployed form in order to detect a cavity (50, 52) and to position itself therein with reference to the position thereof. (a) a carrier element configured to carry artificial valves and configured to be able to be deployed from a collapsed configuration to a deployed configuration; and (b) a catheter assembly (3, 41, 42, 60) configured to hold the implantation device in a collapsed configuration when moving to a position upstream of the final targeted position; (c) at least one feeler element (30, 31) extending from the carrier element, the carrier element and the feeler elements (30, 31) being disposed so that natural valves can be pinched between the carrier element and the feeler elements (30, 31); while said at least one feeler element (30, 31) is deformable and is arranged to change from a collapsed form to an operational deployed form in order to detect a cavity (50, 52) and to position itself therein with reference to the position thereof.
Printed circuit board for an LED module, comprising a plug connector which has four terminals (13.1-13.4); wherein a first LED light source can be connected between a first anode-cathode pair (13.1, 13.4) of the four terminals (13.1-13.4); wherein a second LED light source can be connected between a second anode-cathode pair (13.2, 13.3) of the four terminals (13.1-13.4); characterized by mechanical weakenings in a substrate of the printed circuit board which form at least one at least electrically interruptible substrate bridge (12A, 12B); wherein a pair of anodes (13.1, 13.2) of the four terminals (13.1-13.4) is galvanically interconnected via a first of the at least one substrate bridge (12A, 12B); wherein the printed circuit board can be connected by means of the plug connector to at least one LED driver for the LED module via two or three separate galvanic connections depending on the state of the at least one substrate bridge (12A, 12B). a plug connector which has four terminals (13.1-13.4); wherein a first LED light source can be connected between a first anode-cathode pair (13.1, 13.4) of the four terminals (13.1-13.4); wherein a second LED light source can be connected between a second anode-cathode pair (13.2, 13.3) of the four terminals (13.1-13.4); characterized by mechanical weakenings in a substrate of the printed circuit board which form at least one at least electrically interruptible substrate bridge (12A, 12B); wherein a pair of anodes (13.1, 13.2) of the four terminals (13.1-13.4) is galvanically interconnected via a first of the at least one substrate bridge (12A, 12B); wherein the printed circuit board can be connected by means of the plug connector to at least one LED driver for the LED module via two or three separate galvanic connections depending on the state of the at least one substrate bridge (12A, 12B).
A bone fastener assembly for connecting a bone to a stabilizing construct, comprising: a connecting member having a connecting member axis extending from a proximal end to a distal end, a first opening adjacent the proximal end and a second opening adjacent the distal end; a single piece fastener seat having a first end, a second end, a seat axis extending therebetween, a passageway communicating from the first end to the second end parallel to the seat axis, and a notch extending radially outward from the passageway; and a bone fastener having a bone engaging portion, a head, and a fastener axis extending therebetween, characterized in that the single piece fastener seat comprises an outer edge bisected by the notch and the notch includes a width sized to receive a portion of a shank of the fastener into the passageway as the fastener seat is moved from a first position to a second position, wherein the fastener seat being insertable through the first opening and the bone fastener being insertable through the second opening, the fastener seat insertable through the first opening in the first position in which the seat axis is transverse to the connecting member axis when the fastener seat and bone fastener are inserted into the connecting member and the fastener seat engages the head in the second position in which the seat axis is parallel to the connecting member axis and retains the fastener in the connecting member. a connecting member having a connecting member axis extending from a proximal end to a distal end, a first opening adjacent the proximal end and a second opening adjacent the distal end; a single piece fastener seat having a first end, a second end, a seat axis extending therebetween, a passageway communicating from the first end to the second end parallel to the seat axis, and a notch extending radially outward from the passageway; and a bone fastener having a bone engaging portion, a head, and a fastener axis extending therebetween, characterized in that the single piece fastener seat comprises an outer edge bisected by the notch and the notch includes a width sized to receive a portion of a shank of the fastener into the passageway as the fastener seat is moved from a first position to a second position, wherein the fastener seat being insertable through the first opening and the bone fastener being insertable through the second opening, the fastener seat insertable through the first opening in the first position in which the seat axis is transverse to the connecting member axis when the fastener seat and bone fastener are inserted into the connecting member and the fastener seat engages the head in the second position in which the seat axis is parallel to the connecting member axis and retains the fastener in the connecting member.
A body for an acoustic resonance fluid flow speed sensor comprising a reflector with a surface with at least one section which extends radially from a centre to an edge of the reflector surface, wherein the at least one section (22, 26) is more hydrophilic than a surrounding section of the reflector surface which extends to the edge of the reflector surface, the at least one more hydrophilic section being configured to provide movement of water in a radial direction via the more hydrophilic section (22, 26) from the centre to the edge of the reflector surface.
A needleless injection device comprising a chamber containing a pyrotechnic material, the chamber having a fixed double membrane (13, 15) at a discharge opening, the fixed double membrane consisting of a skin-side membrane and a combustion-chamber-side membrane wherein the skin-side membrane of the double membrane (13, 15) is provided with a substance application to the skin side of the skin-side membrane, characterized in that the combustion-chamber-side membrane and the skin-side membrane are wholly or partially curved towards the chamber.