A medical device, comprising: an actuator configured to be manipulated by an operator of the medical device; an outer cannula extending from the actuator along an axis, and the outer cannula comprises a hub mounted to the actuator, and a primary lumen extending through the outer cannula to a tissue reception port formed in the outer cannula, and the outer cannula comprises a variable axial shape along the axis, the variable axial shape comprises a proximal portion that is circular in radial sectional shape between the hub and a distal portion of the outer cannula, and the distal portion is non-circular in radial sectional shape; an inner cannula located inside the outer cannula and extending in an axial direction, the inner cannula having an inner lumen extending through the inner cannula that is configured to be actuated to collect a tissue sample via the tissue reception port and transport the tissue sample; characterized in that the medical device further comprises a marker placement device having a secondary lumen separated from the primary lumen of the outer cannula by a wall, wherein the marker placement device is configured to be actuated to deploy a marker at a biopsy site via a marker deployment port; and wherein the tissue sampling and marker placement functions are integrated within the medical device such that the medical device operates as a single apparatus configured to perform both tissue sampling and marker placement functions, and wherein the wall separating the primary lumen from the secondary lumen serves to independently seal and separate the marker placement function from the tissue sampling function. an actuator configured to be manipulated by an operator of the medical device; an outer cannula extending from the actuator along an axis, and the outer cannula comprises a hub mounted to the actuator, and a primary lumen extending through the outer cannula to a tissue reception port formed in the outer cannula, and the outer cannula comprises a variable axial shape along the axis, the variable axial shape comprises a proximal portion that is circular in radial sectional shape between the hub and a distal portion of the outer cannula, and the distal portion is non-circular in radial sectional shape; an inner cannula located inside the outer cannula and extending in an axial direction, the inner cannula having an inner lumen extending through the inner cannula that is configured to be actuated to collect a tissue sample via the tissue reception port and transport the tissue sample; characterized in that the medical device further comprises a marker placement device having a secondary lumen separated from the primary lumen of the outer cannula by a wall, wherein the marker placement device is configured to be actuated to deploy a marker at a biopsy site via a marker deployment port; and wherein the tissue sampling and marker placement functions are integrated within the medical device such that the medical device operates as a single apparatus configured to perform both tissue sampling and marker placement functions, and wherein the wall separating the primary lumen from the secondary lumen serves to independently seal and separate the marker placement function from the tissue sampling function.