mhurhangee/ep-ind-claims huggingface dataset:
A method for determining fraction of molecules comprising a methylated sequence in a sample of analyte DNA molecules comprising the sequence, comprising: treating a sample of analyte DNA molecules from plasma or stool with bisulfite ions to selectively modify unmethylated cytosine residues, without degrading the majority of the analyte DNA molecules, wherein the sample is from a human who is being screened for or suspected of having a colon adenoma or colon cancer; forming microemulsions comprising the treated analyte DNA molecules; amplifying a portion of a treated analyte DNA molecule in the microemulsions in the presence of beads, wherein said portion comprises one or more 5 '-CpG methylation sites that are hypermethylated in cancer cells, wherein the beads are bound to a plurality of molecules of a primer for amplifying the analyte DNA molecules, whereby a plurality of copies of analyte DNA molecule are formed covalently attached to the plurality of molecules of the primer which are bound to beads; determining nucleotide sequences at the one or more 5 '-CpG methylation sites of analyte DNA molecules which are bound to beads and quantitating beads that have modified 5'-CpG methylation sites and beads that have unmodified 5'-CpG methylation sites. treating a sample of analyte DNA molecules from plasma or stool with bisulfite ions to selectively modify unmethylated cytosine residues, without degrading the majority of the analyte DNA molecules, wherein the sample is from a human who is being screened for or suspected of having a colon adenoma or colon cancer; forming microemulsions comprising the treated analyte DNA molecules; amplifying a portion of a treated analyte DNA molecule in the microemulsions in the presence of beads, wherein said portion comprises one or more 5 '-CpG methylation sites that are hypermethylated in cancer cells, wherein the beads are bound to a plurality of molecules of a primer for amplifying the analyte DNA molecules, whereby a plurality of copies of analyte DNA molecule are formed covalently attached to the plurality of molecules of the primer which are bound to beads; determining nucleotide sequences at the one or more 5 '-CpG methylation sites of analyte DNA molecules which are bound to beads and quantitating beads that have modified 5'-CpG methylation sites and beads that have unmodified 5'-CpG methylation sites.
A method for the preparation of a non-toxic composition comprising 40-60% by weight of an aqueous solution of hydroxymethylaminoacetate in the form of its alkali metal salt which comprises reacting a salt of glycine with formaldehyde in an aqueous medium at a pH of 10.5 - 12.5, at a temperature of 15-25°C and at a molar ratio of glycine to formaldehyde of 1.005 - 1.1: 1, whereby the amount of free formaldehyde in the composition is less than 90 ppm.
A method for producing N-acylamino triol represented by the following formula: wherein R 1 represents a saturated or unsaturated aliphatic hydrocarbon group having from 8 to 20 carbon atoms and R 2 represents a saturated or unsaturated aliphatic hydrocarbon group having from 7 to 27 carbon atoms which may have a hydroxyl group, the method comprising reacting amino triol represented by the following formula: wherein R 1 has the same meaning as above, with a fatty acid ester represented by the following formula: R 2 COOR 3 wherein R 2 has the same meaning as above and R 3 represents an alkyl group having from 1 to 6 carbon atoms, in ethanol and/or methanol in the presence of a basic catalyst, wherein the amount of the ethanol and/or methanol is 2 to 15 times (mass) the theoretical yield of N-acylamino triol.
Apparatus for applying current to a nerve having a longitudinal central axis, comprising: a housing, adapted to be placed in a vicinity of the nerve, and shaped so as to define first and second end walls; first and second electrodes, fixed within the housing between the end walls; and an insulating element, fixed to the housing between the first and second electrodes so as to define a characteristic closest insulating element perpendicular distance to the central axis, wherein the first and second electrodes are fixed within the housing so as to define respective first and second closest electrode perpendicular distances to the axis, when the housing is placed in the vicinity of the nerve, and wherein the first and second closest electrode perpendicular distances are both greater than: (a) the closest insulating element perpendicular distance, (b) a closest perpendicular distance between the first end wall and the axis, and (c) a closest perpendicular distance between the second end wall and the axis. a housing, adapted to be placed in a vicinity of the nerve, and shaped so as to define first and second end walls; first and second electrodes, fixed within the housing between the end walls; and an insulating element, fixed to the housing between the first and second electrodes so as to define a characteristic closest insulating element perpendicular distance to the central axis, wherein the first and second electrodes are fixed within the housing so as to define respective first and second closest electrode perpendicular distances to the axis, when the housing is placed in the vicinity of the nerve, and wherein the first and second closest electrode perpendicular distances are both greater than: (a) the closest insulating element perpendicular distance, (b) a closest perpendicular distance between the first end wall and the axis, and (c) a closest perpendicular distance between the second end wall and the axis.
A clock recovery apparatus, comprising: an analog-to-digital converter configured to sample an analog input signal by using a sampling clock to output a digital input signal; a multi-phase clock generating circuit coupled to the analog-to-digital converter and configured to output the sampling clock to the analog-to-digital converter and to control a phase of the sampling clock according to a phase selection signal; and a clock recovery circuit coupled to the analog-to-digital converter and the multi-phase clock generating circuit and configured to receive the digital input signal, wherein the clock recovery circuit is configured to output the phase selection signal to the multi-phase clock generating circuit, wherein in a first period, the clock recovery circuit is configured to detect a phase shift of the digital input signal to generate the phase selection signal and is further configure to estimate a phase-offset parameter by detecting the phase shift of the digital input signal generating a phase control signal (P_c) and counting a pulse number of the phase control signal (P_c), and in a second period after the first period, the clock recovery circuit is configured to generate the phase selection signal according to the phase-offset parameter generated in the first period and the phase shift of the digital input signal. an analog-to-digital converter configured to sample an analog input signal by using a sampling clock to output a digital input signal; a multi-phase clock generating circuit coupled to the analog-to-digital converter and configured to output the sampling clock to the analog-to-digital converter and to control a phase of the sampling clock according to a phase selection signal; and a clock recovery circuit coupled to the analog-to-digital converter and the multi-phase clock generating circuit and configured to receive the digital input signal, wherein the clock recovery circuit is configured to output the phase selection signal to the multi-phase clock generating circuit, wherein in a first period, the clock recovery circuit is configured to detect a phase shift of the digital input signal to generate the phase selection signal and is further configure to estimate a phase-offset parameter by detecting the phase shift of the digital input signal generating a phase control signal (P_c) and counting a pulse number of the phase control signal (P_c), and in a second period after the first period, the clock recovery circuit is configured to generate the phase selection signal according to the phase-offset parameter generated in the first period and the phase shift of the digital input signal.
A reconstructive breast prosthesis suitable for implantation into a void in a breast following a lumpectomy procedure in which a body of tissue is excised from the breast, the reconstructive breast prosthesis comprising: a compressible implant body with a sealed non-liquid filled interior at least generally configured to assume an implant shape corresponding to the shape of the body of tissue excised from the breast and having a general egg shape; and an implant shape retaining structure adapted to maintain said implant body in said implant shape, said implant shape retaining structure comprises a coil spring configured to resist collapse, and a mesh configured to prevent undesired expansion by defining a fixed surface area of the implant body; said reconstructive breast prosthesis having an overall density which is less than the density of the body of tissue excised from the breast. a compressible implant body with a sealed non-liquid filled interior at least generally configured to assume an implant shape corresponding to the shape of the body of tissue excised from the breast and having a general egg shape; and an implant shape retaining structure adapted to maintain said implant body in said implant shape, said implant shape retaining structure comprises a coil spring configured to resist collapse, and a mesh configured to prevent undesired expansion by defining a fixed surface area of the implant body; said reconstructive breast prosthesis having an overall density which is less than the density of the body of tissue excised from the breast.
A propeller shaft assembly with a fall-off preventing structure having a first propeller shaft and a second propeller shaft, the first propeller shaft comprising a spline shaft on which a companion flange is spline fitted; the second propeller shaft comprising a spline shaft and a spline yoke, said spline shaft of the second propeller shaft being spline fitted in the spline yoke, said spline yoke being coupled to the companion flange via an universal joint, a nut being screwed on a front end side of the spline shaft of the first propeller shaft, thereby fastening and fixing the companion flange in an axial direction of the spline shaft of the first propeller shaft; a round shaft part is provided on the front end of the spline shaft of the first propeller shaft on which the nut is screwed, characterized by a spline engagement length of the companion flange and the spline shaft of the first propeller shaft being shorter than a slide amount of the spline yoke and the spline shaft of the second propeller shaft, wherein a length of a threaded part of the spline shaft front end side on which the nut is screwed and the round shaft part is set longer than a length from a front end portion of the companion flange to a seat surface of the nut; and a total length of the length of the threaded part and the round shaft part and a length from the front end portion of the companion flange to the seat surface of the nut is set longer than the slide amount.
Method for coating micromechanical components of a micromechanical system, in particular a watch movement, comprising: - providing a substrate component to be coated; - providing said component with a diamond coating; - wherein said diamond coating conductivity is increased in order to reduce particle (debris/dust) attraction by the coated component when used in said micromechanical system, and wherein the diamond coating surface is further doped with an element or material rendering the surface hydrophobic said element or material being selected from the list including fluorine, wax, oils and wherein the diamond coating is deposited so as to be H-terminated or F-terminated -, and wherein said diamond layer is formed of diamond grains having a size less than 30 nanometers and preferably less than 10 nanometers and most preferably less than 8 nanometers;. - providing a substrate component to be coated; - providing said component with a diamond coating; - wherein said diamond coating conductivity is increased in order to reduce particle (debris/dust) attraction by the coated component when used in said micromechanical system, and wherein the diamond coating surface is further doped with an element or material rendering the surface hydrophobic said element or material being selected from the list including fluorine, wax, oils and wherein the diamond coating is deposited so as to be H-terminated or F-terminated -, and wherein said diamond layer is formed of diamond grains having a size less than 30 nanometers and preferably less than 10 nanometers and most preferably less than 8 nanometers;.
A signal acquisition system comprising: a signal acquisition probe having probe tip circuitry coupled to a resistive center conductor signal cable; and a signal processing instrument having an input node coupled to the resistive center conductor signal cable of the signal acquisition probe and coupled to a compensation system disposed in the signal processing instrument via input circuitry; wherein the signal acquisition probe and the signal processing instrument have mismatched time constants at the input node with the compensation system providing pole-zero pairs for maintaining flatness over the signal acquisition system frequency bandwidth. a signal acquisition probe having probe tip circuitry coupled to a resistive center conductor signal cable; and a signal processing instrument having an input node coupled to the resistive center conductor signal cable of the signal acquisition probe and coupled to a compensation system disposed in the signal processing instrument via input circuitry; wherein the signal acquisition probe and the signal processing instrument have mismatched time constants at the input node with the compensation system providing pole-zero pairs for maintaining flatness over the signal acquisition system frequency bandwidth.
The compound represented by: for use in a method of treating a tenosynovial giant cell tumor in a patient in need thereof, comprising orally administering to the patient a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof.
A composite plate comprising a laminate including a zirconia sintered body, an adhesive layer, and a base material having an elastic modulus of 100 GPa or less, and the composite plate has a thickness of 2 mm or less and an apparent density of 4.3 g/cm 3 or less.
A method for assembling a razor handle, the method comprising: installing a rod into a first shell of a body of a razor handle, installing an attachment end of a head onto a front end of the first shell; installing a clip member onto a rear end of the first shell; positioning a second shell adjacent to the first shell; compressing the first shell and the second shell together; and covering the first and second shells (30, 32) with a cover layer. installing a rod into a first shell of a body of a razor handle, installing an attachment end of a head onto a front end of the first shell; installing a clip member onto a rear end of the first shell; positioning a second shell adjacent to the first shell; compressing the first shell and the second shell together; and covering the first and second shells (30, 32) with a cover layer.
Synergistic fungicidal and/or insecticidal and/or acaricidal and/or nematicidal active ingredient combinations comprising N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide (I-1) and the N-oxides thereof; and at least one insecticidal or nematicidal active ingredient selected from the group consisting of Bacillus firmus, Bacillus firmus 1-1582 (II-20a). N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide (I-1) and the N-oxides thereof; and at least one insecticidal or nematicidal active ingredient selected from the group consisting of Bacillus firmus, Bacillus firmus 1-1582 (II-20a).
An autofocus method for determining an optimized focal plane for at least one object recorded by digital holography, said focal plane being defined by a focal depth parameter, the method comprising: - reconstructing a holographic image of said at least one object such as to provide a reconstructed image at a plurality of different focal depths, the reconstructed image comprising a real component and an imaginary component for jointly encoding phase and amplitude information; - performing a first edge detection on said real component for at least two depths of said plurality of different focal depths and a second edge detection on said imaginary component for said at least two depths; - obtaining a first measure of clearness of the edge or boundary of the at least one object for each of said at least two depths based on a first measure of statistical dispersion with respect to the first edge detection and a second measure of clearness for each of said at least two depths based on a second measure of statistical dispersion with respect to the second edge detection; and - determining the optimized focal plane among the images reconstructed at said at least two depths for the at least one object based on a comparison of a scalar measure of clearness for said at least two depths, wherein said scalar measure is based on the first measure of clearness and the second measure of clearness. - reconstructing a holographic image of said at least one object such as to provide a reconstructed image at a plurality of different focal depths, the reconstructed image comprising a real component and an imaginary component for jointly encoding phase and amplitude information; - performing a first edge detection on said real component for at least two depths of said plurality of different focal depths and a second edge detection on said imaginary component for said at least two depths; - obtaining a first measure of clearness of the edge or boundary of the at least one object for each of said at least two depths based on a first measure of statistical dispersion with respect to the first edge detection and a second measure of clearness for each of said at least two depths based on a second measure of statistical dispersion with respect to the second edge detection; and - determining the optimized focal plane among the images reconstructed at said at least two depths for the at least one object based on a comparison of a scalar measure of clearness for said at least two depths, wherein said scalar measure is based on the first measure of clearness and the second measure of clearness.
A smoking article comprising a tobacco substrate and a filter, the filter comprising: a filter segment comprising filter material, the filter segment having a cross sectional area measured perpendicular to the longitudinal direction of the filter; and a flavour delivery member embedded in the filter segment and surrounded on all sides by the filter material, the flavour delivery member comprising structural material enclosing liquid flavourant for flavouring smoke during smoking, wherein the flavour delivery member releases at least a portion of the liquid flavourant when the filter is subjected to external force; wherein a cross sectional area of the flavour delivery member measured perpendicular to the longitudinal direction of the filter is about 30%, or greater, of the cross sectional area of the filter segment, and wherein the filter material of the filter segment comprises fibres of between about 5.0 and about 12.0 denier per filament and between about 10000 and about 30000 total denier; wherein the filter segment and the flavour delivery member are circular in cross section, the diameter of the filter segment is between 3.6 mm and 6.5 mm and the diameter of the flavour delivery member is between 2.5 mm and 4.5 mm; wherein the resistance to draw of the smoking article, before the liquid flavourant is released, is greater than 130 mm H2O; and wherein the flavour delivery member comprises a capsule and the capsule has a burst strength of between about 5 N and about 24 N. a filter segment comprising filter material, the filter segment having a cross sectional area measured perpendicular to the longitudinal direction of the filter; and a flavour delivery member embedded in the filter segment and surrounded on all sides by the filter material, the flavour delivery member comprising structural material enclosing liquid flavourant for flavouring smoke during smoking, wherein the flavour delivery member releases at least a portion of the liquid flavourant when the filter is subjected to external force; wherein a cross sectional area of the flavour delivery member measured perpendicular to the longitudinal direction of the filter is about 30%, or greater, of the cross sectional area of the filter segment, and wherein the filter material of the filter segment comprises fibres of between about 5.0 and about 12.0 denier per filament and between about 10000 and about 30000 total denier; wherein the filter segment and the flavour delivery member are circular in cross section, the diameter of the filter segment is between 3.6 mm and 6.5 mm and the diameter of the flavour delivery member is between 2.5 mm and 4.5 mm; wherein the resistance to draw of the smoking article, before the liquid flavourant is released, is greater than 130 mm H2O; and wherein the flavour delivery member comprises a capsule and the capsule has a burst strength of between about 5 N and about 24 N.
An aqueous coating composition comprising an aqueous base component and a water-dispersible curing agent, wherein the aqueous base component comprises an aqueous acrylic resin dispersion and an aqueous polyolefin wax dispersion, wherein the water-dispersible curing agent comprises a water-dispersible polyisocyanate, wherein at least one of the aqueous base component and the water-dispersible curing agent comprises an organic solvent having a solubility in water at 20°C of 0.1 to 14 g/100gH 2 O and a boiling point in the range of 150 to 230°C, wherein the aqueous acrylic resin dispersion has a hydroxyl value in the range of 5 to 200 mgKOH/g, an acid value in the range of 5 to 100 mgKOH/g, and a number-average molecular weight in the range of 1,000 to 100,000, wherein the aqueous polyolefin wax dispersion has an average particle diameter in the range of 50 to 1,000 nm, wherein the hydroxyl value and the acid value of the aqueous acrylic resin dispersion are both measured by the methods in accordance with JIS K 0070, wherein the number average molecular weight of the aqueous acrylic resin dispersion is measured by gel permeation chromatography using polystyrene standards, and wherein the average particle diameter of the aqueous polyolefin wax dispersion is measured by electrophoretic light scattering photometer. wherein the aqueous base component comprises an aqueous acrylic resin dispersion and an aqueous polyolefin wax dispersion, wherein the water-dispersible curing agent comprises a water-dispersible polyisocyanate, wherein at least one of the aqueous base component and the water-dispersible curing agent comprises an organic solvent having a solubility in water at 20°C of 0.1 to 14 g/100gH 2 O and a boiling point in the range of 150 to 230°C, wherein the aqueous acrylic resin dispersion has a hydroxyl value in the range of 5 to 200 mgKOH/g, an acid value in the range of 5 to 100 mgKOH/g, and a number-average molecular weight in the range of 1,000 to 100,000, wherein the aqueous polyolefin wax dispersion has an average particle diameter in the range of 50 to 1,000 nm, wherein the hydroxyl value and the acid value of the aqueous acrylic resin dispersion are both measured by the methods in accordance with JIS K 0070, wherein the number average molecular weight of the aqueous acrylic resin dispersion is measured by gel permeation chromatography using polystyrene standards, and wherein the average particle diameter of the aqueous polyolefin wax dispersion is measured by electrophoretic light scattering photometer.