A peptidomimetic macrocycle of the formula: or a pharmaceutically acceptable salt thereof, wherein: each of Xaa 3, Xaa 5, Xaa 6, Xaa 7, Xaa 8, Xaa 9, and Xaa 10 is independently an amino acid, wherein at least three of Xaa 3, Xaa 5, Xaa 6, Xaa 7, Xaa 8, Xaa 9, and Xaa 10 are the same amino acids as the amino acid at the corresponding position of the sequence Phe 3 -X 4 -His 5 -Tyr 6 -Trp 7 -Ala 8 -Gln 9 -Leu 10 -X 11 -Ser 12 (SEQ ID NO: 8), wherein each X 4 and X 11 is independently an amino acid; each D is independently an amino acid; each E is independently an amino acid selected from the group consisting of Ala (alanine), D-Ala (D-alanine), Aib (a-aminoisobutyric acid), Sar (N-methyl glycine), and Ser (serine); R 1 and R 2 are independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, or heterocycloalkyl, unsubstituted or substituted with halo-; or forms a macrocycle-forming linker L' connected to the alpha position of one of said D or E amino acids; each R 3 is independently -H, alkyl, alkenyl, alkynyl, arylalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, aryl, or heteroaryl, optionally substituted with R 5; L and L' are independently a macrocycle-forming linker of the formula L 1 -L 2 -; each L 1 and L 2 is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, or [-R 4 -K-R 4 -] n, each being optionally substituted with R 5; each R 4 is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene; each K is independently O, S, SO, SO 2, CO, CO 2, or CONR 3; each R 5 is independently halogen, alkyl, -OR 6, -N(R 6) 2, -SR 6, -SOR 6, -SO 2 R 6, -CO 2 R 6, a fluorescent moiety, a radioisotope or a therapeutic agent; each R 6 is independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent; R 7 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R 5, or part of a cyclic structure with a D residue; R 8 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R 5, or part of a cyclic structure with an E residue; v is an integer from 1-1000; w is an integer from 3-1000; and n is an integer from 1-5. each of Xaa 3, Xaa 5, Xaa 6, Xaa 7, Xaa 8, Xaa 9, and Xaa 10 is independently an amino acid, wherein at least three of Xaa 3, Xaa 5, Xaa 6, Xaa 7, Xaa 8, Xaa 9, and Xaa 10 are the same amino acids as the amino acid at the corresponding position of the sequence Phe 3 -X 4 -His 5 -Tyr 6 -Trp 7 -Ala 8 -Gln 9 -Leu 10 -X 11 -Ser 12 (SEQ ID NO: 8), wherein each X 4 and X 11 is independently an amino acid; each D is independently an amino acid; each E is independently an amino acid selected from the group consisting of Ala (alanine), D-Ala (D-alanine), Aib (a-aminoisobutyric acid), Sar (N-methyl glycine), and Ser (serine); R 1 and R 2 are independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, or heterocycloalkyl, unsubstituted or substituted with halo-; or forms a macrocycle-forming linker L' connected to the alpha position of one of said D or E amino acids; each R 3 is independently -H, alkyl, alkenyl, alkynyl, arylalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, aryl, or heteroaryl, optionally substituted with R 5; L and L' are independently a macrocycle-forming linker of the formula L 1 -L 2 -; each L 1 and L 2 is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, or [-R 4 -K-R 4 -] n, each being optionally substituted with R 5; each R 4 is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene; each K is independently O, S, SO, SO 2, CO, CO 2, or CONR 3; each R 4 is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene; each K is independently O, S, SO, SO 2, CO, CO 2, or CONR 3; each R 5 is independently halogen, alkyl, -OR 6, -N(R 6) 2, -SR 6, -SOR 6, -SO 2 R 6, -CO 2 R 6, a fluorescent moiety, a radioisotope or a therapeutic agent; each R 6 is independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent; R 7 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R 5, or part of a cyclic structure with a D residue; R 8 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R 5, or part of a cyclic structure with an E residue; v is an integer from 1-1000; w is an integer from 3-1000; and n is an integer from 1-5.