A compound represented by formula or wherein R 1 is (C 1 -C 5 alkyl)O, (C 1 -C 2 alkyl)O(CH 2) 2-3 O, (C 1 -C 5 alkyl)C(=O)O, (C 1 -C 5 alkyl)NH, (C 1 -C 2 alkyl)O(CH 2) 2-3 NH, or (C 1 -C 5 alkyl)C(=O)NH; R 2 is, independently for each occurrence thereof, H, C 1 -C 3 alkyl, halo, O(C 1 -C 3 alkyl), CN, or NO 2; X is, independently for each occurrence thereof, CR 2 or N; R 3 is O, S, NH, or N(C 1 -C 3 alkyl); Ar is where one of Y, Y' and Y" is selected from -O-, -S-, -NH- and -N(C 1 -C 3 alkyl)-and the other two of Y, Y', and Y" are selected from =N- and =CR 2 -; R 4 is H, C 1 -C 3 alkyl, halo, O(C 1 -C 3 alkyl), CN, NO 2, or (CH 2) x R 5, where the subscript x is 1, 2, 3, or 4; and R 5 is H, halo, OH, CN, NH 2, NH(C 1 -C 5 alkyl), N(C 1 -C 5 alkyl) 2, NH(C 3 -C 6 cycloalkyl), NH(C 4 -C 8 bicycloalkyl), NH(C 6 -C 10 spirocycloalkyl), N(C 3 -C 6 cycloalkyl) 2, NH(CH 2) 1-3 (aryl), N((CH 2) 1-3 (aryl)) 2, a cyclic amine moiety having the structure a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety; wherein an alkyl, cycloalkyl, bicycloalkyl, spriocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C 1 -C 3 alkyl), O(C 1 -C 3 alkyl), C(=O)(Me), SO 2 (C 1 -C 3 alkyl), C(=O)(Et), NH 2, NH(Me), N(Me) 2, NH(Et), N(Et) 2, and N(C 1 -C 3 alkyl) 2; and a cycloalkyl, bicycloalkyl, sprioalkyl, or cyclic amine moiety may have a CH 2 group replaced by O, S, NH, N(C 1 -C 3 alkyl), or N(Boc). R 1 is (C 1 -C 5 alkyl)O, (C 1 -C 2 alkyl)O(CH 2) 2-3 O, (C 1 -C 5 alkyl)C(=O)O, (C 1 -C 5 alkyl)NH, (C 1 -C 2 alkyl)O(CH 2) 2-3 NH, or (C 1 -C 5 alkyl)C(=O)NH; R 2 is, independently for each occurrence thereof, H, C 1 -C 3 alkyl, halo, O(C 1 -C 3 alkyl), CN, or NO 2; X is, independently for each occurrence thereof, CR 2 or N; R 3 is O, S, NH, or N(C 1 -C 3 alkyl); Ar is where one of Y, Y' and Y" is selected from -O-, -S-, -NH- and -N(C 1 -C 3 alkyl)-and the other two of Y, Y', and Y" are selected from =N- and =CR 2 -; R 4 is H, C 1 -C 3 alkyl, halo, O(C 1 -C 3 alkyl), CN, NO 2, or (CH 2) x R 5, where the subscript x is 1, 2, 3, or 4; and R 5 is H, halo, OH, CN, NH 2, NH(C 1 -C 5 alkyl), N(C 1 -C 5 alkyl) 2, NH(C 3 -C 6 cycloalkyl), NH(C 4 -C 8 bicycloalkyl), NH(C 6 -C 10 spirocycloalkyl), N(C 3 -C 6 cycloalkyl) 2, NH(CH 2) 1-3 (aryl), N((CH 2) 1-3 (aryl)) 2, a cyclic amine moiety having the structure a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety; wherein an alkyl, cycloalkyl, bicycloalkyl, spriocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C 1 -C 3 alkyl), O(C 1 -C 3 alkyl), C(=O)(Me), SO 2 (C 1 -C 3 alkyl), C(=O)(Et), NH 2, NH(Me), N(Me) 2, NH(Et), N(Et) 2, and N(C 1 -C 3 alkyl) 2; and a cycloalkyl, bicycloalkyl, sprioalkyl, or cyclic amine moiety may have a CH 2 group replaced by O, S, NH, N(C 1 -C 3 alkyl), or N(Boc). an alkyl, cycloalkyl, bicycloalkyl, spriocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C 1 -C 3 alkyl), O(C 1 -C 3 alkyl), C(=O)(Me), SO 2 (C 1 -C 3 alkyl), C(=O)(Et), NH 2, NH(Me), N(Me) 2, NH(Et), N(Et) 2, and N(C 1 -C 3 alkyl) 2; and a cycloalkyl, bicycloalkyl, sprioalkyl, or cyclic amine moiety may have a CH 2 group replaced by O, S, NH, N(C 1 -C 3 alkyl), or N(Boc).