A fluid control and processing system comprising: - a cartridge; - an instrument being designed for operating the cartridge; - at least a cylinder body being received in the cartridge, said at least a cylinder body comprising a cylinder and at least a fluid port in fluid communication with said cylinder; - a piston being movable in translation along an axis A in the cylinder to modulate a fluid volume inside said cylinder; the instrument comprising a piston driver, said piston driver being designed for driving the piston in rotation and in translation around and along the axis A; the fluid control and processing system further comprising: - dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with the at least a fluid port of the cylinder port by rotation of the cylinder body; - reversible fastening means for fastening the piston to the piston driver when the piston driver is rotated with respect to the piston in a first direction around the axis A which extends along the piston driver; and said reversible fastening means being designed for unfastening the piston from the piston driver when the piston driver is rotated with respect to the piston in a second direction opposite to the first direction, so that the movement of the piston is controlled by the piston driver; - rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A, and thereby the fluid port, in order to place the fluid port in fluid communication with at least one of the dispensing ports; - interlocking means (24, 25) for interlocking the piston driver and the cylinder driver, so that the rotation of the cylinder body is controllable by the piston driver, when the piston driver and the piston are fastened by the fastening means. - a cartridge; - an instrument being designed for operating the cartridge; - at least a cylinder body being received in the cartridge, said at least a cylinder body comprising a cylinder and at least a fluid port in fluid communication with said cylinder; - a piston being movable in translation along an axis A in the cylinder to modulate a fluid volume inside said cylinder; - dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge, with the at least a fluid port of the cylinder port by rotation of the cylinder body; - reversible fastening means for fastening the piston to the piston driver when the piston driver is rotated with respect to the piston in a first direction around the axis A which extends along the piston driver; and said reversible fastening means being designed for unfastening the piston from the piston driver when the piston driver is rotated with respect to the piston in a second direction opposite to the first direction, so that the movement of the piston is controlled by the piston driver; - rotating means comprising a cylinder driver constitutive of the instrument for rotating the cylinder body around the axis A, and thereby the fluid port, in order to place the fluid port in fluid communication with at least one of the dispensing ports; - interlocking means (24, 25) for interlocking the piston driver and the cylinder driver, so that the rotation of the cylinder body is controllable by the piston driver, when the piston driver and the piston are fastened by the fastening means.