mhurhangee/ep-ind-claims huggingface dataset:
A genome editing system, comprising at least one nuclease that generates blunt-ended DNA breaks in a sequence-specific manner, wherein the genome editing system is configured to form a first and a second blunt-ended double strand break in an intron of a gene, wherein the intron comprises a splice donor site mutation that alters splice site recognition, thereby excising a segment of the intron at a mutation-eliminating cut site of the intron and at a splice site-generating cut site of the intron of the gene and simultaneously joining DNA ends flanking the excised segment of the intron through non-homologous end joining to constitute a functional donor splice site; wherein the at least one nuclease is: a) a nuclease that recognizes a Protospacer Adjacent Motif and wherein the system further comprises a mutation-eliminating single guide RNA (sgRNA) and a splice site-generating sgRNA or b) a fusion polypeptide comprising a catalytically inactive nuclease that recognizes a PAM and a nuclease that generates blunt-ended DNA breaks. wherein the genome editing system is configured to form a first and a second blunt-ended double strand break in an intron of a gene, wherein the intron comprises a splice donor site mutation that alters splice site recognition, thereby excising a segment of the intron at a mutation-eliminating cut site of the intron and at a splice site-generating cut site of the intron of the gene and simultaneously joining DNA ends flanking the excised segment of the intron through non-homologous end joining to constitute a functional donor splice site; wherein the at least one nuclease is: a) a nuclease that recognizes a Protospacer Adjacent Motif and wherein the system further comprises a mutation-eliminating single guide RNA (sgRNA) and a splice site-generating sgRNA or b) a fusion polypeptide comprising a catalytically inactive nuclease that recognizes a PAM and a nuclease that generates blunt-ended DNA breaks. a) a nuclease that recognizes a Protospacer Adjacent Motif and wherein the system further comprises a mutation-eliminating single guide RNA (sgRNA) and a splice site-generating sgRNA or b) a fusion polypeptide comprising a catalytically inactive nuclease that recognizes a PAM and a nuclease that generates blunt-ended DNA breaks.
An aerosol-generating system comprising: an acid source; and a nicotine source, wherein the nicotine source is an encapsulated nicotine source, and wherein the acid source is an encapsulated volatile liquid source comprising: a sorption element; a volatile liquid having a vapour pressure of at least about 20 Pa at 25°C sorbed on the sorption element, wherein the volatile liquid comprises a 2-oxo acid; and a sealant having a melting point of between about 40°C and about 120°C encapsulating the sorption element. an acid source; and a nicotine source, wherein the nicotine source is an encapsulated nicotine source, and wherein the acid source is an encapsulated volatile liquid source comprising: a sorption element; a volatile liquid having a vapour pressure of at least about 20 Pa at 25°C sorbed on the sorption element, wherein the volatile liquid comprises a 2-oxo acid; and a sealant having a melting point of between about 40°C and about 120°C encapsulating the sorption element. a sorption element; a volatile liquid having a vapour pressure of at least about 20 Pa at 25°C sorbed on the sorption element, wherein the volatile liquid comprises a 2-oxo acid; and a sealant having a melting point of between about 40°C and about 120°C encapsulating the sorption element.
A control device of a vehicle including an engine, an electric motor, and a first clutch connecting/disconnecting a power transmission path between the engine and the electric motor, and a second clutch (38, C, B) configured to achieve a mechanically directly-coupled state of a power transmission path between the engine/the electric motor and drive wheels, the control device increasing a torque of the electric motor by an increase torque (Tmup) and causing the second clutch to slip-engage when the engine is started by controlling the first clutch toward engagement during motor running using only the electric motor as a drive force source for running with the first clutch released and the second clutch engaged, the control device determining the increase torque (Tmup) that corresponds to an engine start torque (Tms) which is to be transmitted to the engine through the first clutch and which is required for starting the engine, such that the determined increase torque is made larger in a first case where the engine is to be started with the engine start torque (Tms) being larger as compared to a second case where the engine is to be started with the engine start torque (Tms) being smaller, the control device being characterized in that: the control device determines, based on the determined increase torque (Tmup), a target value (Nstgt) of a slip amount (Ns) of the second clutch in the slip engagement upon starting of the engine, such that the target value of the slip amount is made larger in the first case where the increase torque is larger as compared to the second case where the increase torque is smaller; and the control device controls the second clutch in accordance with the determined target value (Nstgt), such that the slip amount of the second clutch is made larger in the first case where the increase torque (Tmup) is larger as compared to the second case where the increase torque is smaller.
Apparatus, comprising: fabric formed from fibers; and an electrical component having a plastic package with opposing first and second surfaces, a first fiber receiving and holding structure in the first surface, and a second fiber receiving and holding structure in the second surface, wherein the second fiber receiving and holding structure is perpendicular to the first fiber receiving and holding structure (96, 96', 96-1, 96-2), wherein a first of the fibers is soldered to a first contact in the first fiber receiving and holding structure and a second of the fibers is soldered to a second contact in the second fiber receiving and holding structure. fabric formed from fibers; and an electrical component having a plastic package with opposing first and second surfaces, a first fiber receiving and holding structure in the first surface, and a second fiber receiving and holding structure in the second surface, wherein the second fiber receiving and holding structure is perpendicular to the first fiber receiving and holding structure (96, 96', 96-1, 96-2), wherein a first of the fibers is soldered to a first contact in the first fiber receiving and holding structure and a second of the fibers is soldered to a second contact in the second fiber receiving and holding structure.
An aerosol delivery system, the aerosol delivery system comprising: an aerosol delivery unit, the aerosol delivery unit comprising: a cartridge receiver, which is configured to receive a cartridge assembly; and an inductor configured to receive the cartridge assembly and heat a liquid formulation within a capillary tube to produce an aerosol by induction heating; and a pump, the pump comprising: a container holder configured to receive a container containing the liquid formulation, and wherein the container holder is configured to pivot about an axis to expose an opening on a bottom of the container holder; a plunger for applying a force to push the liquid formulation out of a distal end of the container into a proximal end of the capillary tube; and a pressure jacket configured to support the container within the container holder. an aerosol delivery unit, the aerosol delivery unit comprising: a cartridge receiver, which is configured to receive a cartridge assembly; and an inductor configured to receive the cartridge assembly and heat a liquid formulation within a capillary tube to produce an aerosol by induction heating; and a cartridge receiver, which is configured to receive a cartridge assembly; and an inductor configured to receive the cartridge assembly and heat a liquid formulation within a capillary tube to produce an aerosol by induction heating; and a pump, the pump comprising: a container holder configured to receive a container containing the liquid formulation, and wherein the container holder is configured to pivot about an axis to expose an opening on a bottom of the container holder; a plunger for applying a force to push the liquid formulation out of a distal end of the container into a proximal end of the capillary tube; and a pressure jacket configured to support the container within the container holder. a container holder configured to receive a container containing the liquid formulation, and wherein the container holder is configured to pivot about an axis to expose an opening on a bottom of the container holder; a plunger for applying a force to push the liquid formulation out of a distal end of the container into a proximal end of the capillary tube; and a pressure jacket configured to support the container within the container holder.
A cooling system for cooling of a combustion engine, wherein the cooling system comprises a radiator inlet line configure to direct coolant to a radiator, a radiator outlet line configured to receive coolant from the radiator, a radiator bypass line configured to direct coolant past the radiator, a cylinder block inlet line configured to direct coolant at a first temperature (T 1) to the cylinder block of the combustion engine and a cylinder block outlet line configured to receive coolant from the cylinder block, a cylinder head inlet line configured to direct coolant at a second temperature (T 2) to the cylinder head of the combustion engine and a cylinder head outlet line configured to receive coolant from the cylinder head, and wherin the cylinder head outlet line is configured to direct coolant to the cylinder block inlet line such that the coolant at the first temperature (T 1) directed to the cylinder block has a higher temperature than the coolant at the second temperature (T 2) directed to the cylinder head, wherein the cooling system comprises a first valve device configured to receive coolant from the cylinder block outlet line and to direct coolant to the radiator inlet line and/or the radiator bypass line and a second valve device configured to receive coolant from the radiator outlet line and/or the radiator bypass line and to direct the coolant to the cylinder block inlet line and the cylinder head inlet line, characterised in that the first valve device is a three way valve.
A method for generating a moiré-corrected image file, comprising the following steps: - capturing a raw image file using an image sensor; - inputting the captured raw image file into a pre-trained artificial neural network, ANN, wherein the ANN is configured to output a computed raw image file representing an image with a blurred region based on the input raw image file; - inputting the computed raw image file into an image processing unit, IPU; and - calculating, by the IPU, an RGB image file based on the computed raw image file; further providing the pre-trained ANN by performing the following steps: - training the ANN by using training data, wherein the training data comprises pairs of training images, and each pair of training images comprises a first training raw image file representing a training image without any blurred region, and a second training raw image file representing a training image with a blurred region; - wherein the first training raw image file is generated by applying a color filter array, CFA, on a training RGB image file; - wherein the second training raw image file is generated by applying an anti-aliasing filter on the training RGB image file and by applying a CFA on the anti-aliasing filtered training RGB image file. - capturing a raw image file using an image sensor; - inputting the captured raw image file into a pre-trained artificial neural network, ANN, wherein the ANN is configured to output a computed raw image file representing an image with a blurred region based on the input raw image file; - inputting the computed raw image file into an image processing unit, IPU; and - calculating, by the IPU, an RGB image file based on the computed raw image file; - training the ANN by using training data, wherein the training data comprises pairs of training images, and each pair of training images comprises a first training raw image file representing a training image without any blurred region, and a second training raw image file representing a training image with a blurred region; - wherein the first training raw image file is generated by applying a color filter array, CFA, on a training RGB image file; - wherein the second training raw image file is generated by applying an anti-aliasing filter on the training RGB image file and by applying a CFA on the anti-aliasing filtered training RGB image file.
A spark plug, comprising: a shaft-shaped center electrode; a ceramic insulator holding an outer circumference of the center electrode; a metal shell holding an outer circumference of the ceramic insulator; and a ground electrode joined to the metal shell. so as to define a spark gap between the center electrode and the ground electrode, the ground electrode having an opposing surface facing a front end of the center electrode, a back surface located opposite from the front end of the center electrode, a protruding portion formed on the opposing surface by extrusion pressing and protruding from the opposing surface toward the front end of the center electrode and a press recessed portion made in the back surface due to the formation of the protruding portion by extrusion pressing and recessed from the back surface toward the front end of the center electrode, wherein a protrusion amount A of the protruding portion from the opposing surface satisfies a relationship of 0.4 mm ≤ A ≤ 1.0 mm; and wherein a width C from a side end (34, 35) of the ground electrode to the press recessed portion satisfies a relationship of 0.4 mm ≤ C ≤ 0.8 mm. a shaft-shaped center electrode; a ceramic insulator holding an outer circumference of the center electrode; a metal shell holding an outer circumference of the ceramic insulator; and a ground electrode joined to the metal shell. so as to define a spark gap between the center electrode and the ground electrode, the ground electrode having an opposing surface facing a front end of the center electrode, a back surface located opposite from the front end of the center electrode, a protruding portion formed on the opposing surface by extrusion pressing and protruding from the opposing surface toward the front end of the center electrode and a press recessed portion made in the back surface due to the formation of the protruding portion by extrusion pressing and recessed from the back surface toward the front end of the center electrode, wherein a protrusion amount A of the protruding portion from the opposing surface satisfies a relationship of 0.4 mm ≤ A ≤ 1.0 mm; and wherein a width C from a side end (34, 35) of the ground electrode to the press recessed portion satisfies a relationship of 0.4 mm ≤ C ≤ 0.8 mm.
Non-destructive testing system including by way of constituent elements an electronic non-destructive measuring device able to be connected to a non-destructive measuring sensor of the type intended to be held in the hand in order to carry out test measurements, an electronic board, an electrical power source, and a control and display screen, said electronic non-destructive measuring device being connected to the electronic board which itself is connected to the electrical power source and to the control and display screen, and cables for electrically and electronically linking said constituent elements to one another, characterized in that said non-destructive testing system includes a jacket-type garment and said constituent elements and said linking cables are integrated into said jacket-type garment, and in that a cable linking the electronic measuring device and a measuring sensor includes, at an end for connecting to said sensor, a connector placed on the exterior of the jacket, on a sleeve of said jacket.
A coated article, in particular a cutting insert for use in a chipforming material removal operation, the article comprising: a substrate and a wear-resistant coating scheme wherein the wear-resistant coating scheme comprising: a mediate multi-periodicity nanolayer coating scheme containing titanium, aluminum, chromium and nitrogen; and the mediate multi-periodicity nanolayer coating scheme comprising a plurality of sets of alternating layer arrangements, wherein each one of the alternating layer arrangements comprises a base layer comprising titanium, aluminum and nitrogen and a nanolayer region comprising a plurality of sets of alternating nanolayers (68, 70, 72) wherein each set of alternating nanolayers comprises one nanolayer comprising aluminum, chromium, titanium and nitrogen and another nanolayer comprising aluminum, chromium, titanium and nitrogen, characterized in that the base layer has a base layer thickness and the nanolayer region has a nanolayer region thickness, the base layer thickness being smaller than the nanolayer region thickness, and wherein the base layer comprises (Ti y Al 1-y)N, wherein 0.2 ≤ y ≤ 0.65 and the one nanolayer of the set of alternating nanolayers in the nanolayer region comprises (Ti y Cr x Al 1-(x+y))N, wherein 0 < x ≤ 0.15 and 0.2 ≤ y ≤ 0.65, and other nanolayer of the set of alternating nanolayers in the nanolayer region comprises (Ti p Al q Cr 1-(p+q))N, wherein 0.2 ≤ p ≤ 0.65 and 0.01 ≤ q ≤ 0.65 and (p + q) < 1. a substrate and a wear-resistant coating scheme wherein the wear-resistant coating scheme comprising: a mediate multi-periodicity nanolayer coating scheme containing titanium, aluminum, chromium and nitrogen; and the mediate multi-periodicity nanolayer coating scheme comprising a plurality of sets of alternating layer arrangements, wherein each one of the alternating layer arrangements comprises a base layer comprising titanium, aluminum and nitrogen and a nanolayer region comprising a plurality of sets of alternating nanolayers (68, 70, 72) wherein each set of alternating nanolayers comprises one nanolayer comprising aluminum, chromium, titanium and nitrogen and another nanolayer comprising aluminum, chromium, titanium and nitrogen, a mediate multi-periodicity nanolayer coating scheme containing titanium, aluminum, chromium and nitrogen; and the mediate multi-periodicity nanolayer coating scheme comprising a plurality of sets of alternating layer arrangements, wherein each one of the alternating layer arrangements comprises a base layer comprising titanium, aluminum and nitrogen and a nanolayer region comprising a plurality of sets of alternating nanolayers (68, 70, 72) wherein each set of alternating nanolayers comprises one nanolayer comprising aluminum, chromium, titanium and nitrogen and another nanolayer comprising aluminum, chromium, titanium and nitrogen,
A coil assembly for a valve control unit, consisting of - a coil body which has a cylindrical cavity on the inside and is surrounded by a wire assembly on the outside, - a valve or valve dome arranged in the cylindrical cavity, and - a coil yoke, characterized in that between the coil body and the valve or valve dome, a perforated disc is arranged which is supported so as to be radially movable and the opening of which has a smaller diameter than the cylindrical cavity. - a coil body which has a cylindrical cavity on the inside and is surrounded by a wire assembly on the outside, - a valve or valve dome arranged in the cylindrical cavity, and - a coil yoke, characterized in that between the coil body and the valve or valve dome, a perforated disc is arranged which is supported so as to be radially movable and the opening of which has a smaller diameter than the cylindrical cavity.
Vehicle door drive for a bus, with an actuator, which is able to be coupled with a vehicle door via a coupling mechanism of the drive, where the coupling mechanism is realized with a traction means drive, wherein a) the actuator is coupled with the rotational axis of a roller of the drive in such a way that an actuation displacement of the actuator induces a shift of the rotational axis of the roller, b) a traction means of the traction means drive wraps around the roller, c) the traction means forms a traction strand, which on one side of the roller extends from the roller to a linking means connected to the vehicle door, and d) the roller on its other side has an instant centre of rotation, e) the linking means for the vehicle door moved with the traction means drive undergoes a translational motion and with the translational motion of the linking means a further hinging point of the vehicle door moves along a curved guide of the drive, in which way the vehicle door undergoes a swinging-sliding motion along with the translational motion of the linking means and/or the motion of the traction means drive at least over a partial stroke is coupled to a rotary column via a coupling rod and an actuation lever. a) the actuator is coupled with the rotational axis of a roller of the drive in such a way that an actuation displacement of the actuator induces a shift of the rotational axis of the roller, b) a traction means of the traction means drive wraps around the roller, c) the traction means forms a traction strand, which on one side of the roller extends from the roller to a linking means connected to the vehicle door, and d) the roller on its other side has an instant centre of rotation, e) the linking means for the vehicle door moved with the traction means drive undergoes a translational motion and with the translational motion of the linking means a further hinging point of the vehicle door moves along a curved guide of the drive, in which way the vehicle door undergoes a swinging-sliding motion along with the translational motion of the linking means and/or the motion of the traction means drive at least over a partial stroke is coupled to a rotary column via a coupling rod and an actuation lever.