A method of specifically releasing one or more members of a sub-group of objects from solid support, the method comprising a) providing a heterogeneous group of objects comprising a homogeneous subgroup of objects, each member of the group of objects being bound to the solid support via a linker; b) contacting the group of objects with an identifier, being capable of specifically binding the subgroup of objects, under conditions allowing the binding of the identifier to the subgroup of objects, wherein the identifier is coupled to a releaser being capable of releasing a member of the subgroup from the solid support by interacting with the linker; c) binding the identifier to the subgroup, thereby bringing the releaser in proximity to the linker; and d) specifically releasing one or more members of the subgroup from the solid support by allowing interaction between releaser and linker;. thereby specifically releasing the one or more members of the subgroup of objects from the solid support, wherein the objects of heterogeneous group of objects are either chemical, biochemical or biological compounds or wherein the heterogeneous group of objects comprising a homogeneous subgroup of objects is a heterogeneous population of cells comprising a homogeneous sub-population of cells, wherein the solid support is (i) a bead, a vessel, a slide, a disk such as a compact disk or an array such as a microarray, and/or (ii) glass, polystyrene, polyacrylamide, poly carbonate, polyethylene glycol, PEG-based or cellulose, optionally having a functionalized surface or being a chemically modified support, and/or (iii) a petri dish, a microwell plate, a chromatography column, a chromatography matrix, a cell culture flask, a tube, a mesh or a membrane, wherein the identifier is selected from the group consisting of a nucleic acid, an antibody or functionally active derivative thereof, a receptor or a binding site thereof, an enzyme or a binding site thereof, a substrate to an enzyme, a tag-binding site, a ligand to a receptor, and a tag, and wherein the releaser is selected from the group consisting of an enzyme, an apoenyzme, or a portion of a split enzyme, a photo sensitizer, an electronically controllable charged group targeting an opposite pole in the linker and a metal complex. a) providing a heterogeneous group of objects comprising a homogeneous subgroup of objects, each member of the group of objects being bound to the solid support via a linker; b) contacting the group of objects with an identifier, being capable of specifically binding the subgroup of objects, under conditions allowing the binding of the identifier to the subgroup of objects, wherein the identifier is coupled to a releaser being capable of releasing a member of the subgroup from the solid support by interacting with the linker; c) binding the identifier to the subgroup, thereby bringing the releaser in proximity to the linker; and d) specifically releasing one or more members of the subgroup from the solid support by allowing interaction between releaser and linker;. (i) a bead, a vessel, a slide, a disk such as a compact disk or an array such as a microarray, and/or (ii) glass, polystyrene, polyacrylamide, poly carbonate, polyethylene glycol, PEG-based or cellulose, optionally having a functionalized surface or being a chemically modified support, and/or (iii) a petri dish, a microwell plate, a chromatography column, a chromatography matrix, a cell culture flask, a tube, a mesh or a membrane,