mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing tadalafil which comprises the following steps: (i) suspending D-tryptophan or a salt thereof or an ester of D-tryptophan with R-OH or a salt thereof and piperonal under acidic conditions in an organic solvent and heating the suspension in a closed reaction vessel above the reflux temperature and at pressure of at least 0.1MPa, or heating the suspension in a closed reaction vessel at an increased pressure at a temperature above the boiling point of the employed organic solvent at normal atmospheric pressure, (ii) chloroacylation of the "in situ" formed intermediate, preferably intermediate A which is a mixture of cis and trans isomer, with formula, where R is C 1 -C 6 alkyl, preferably Me, Et, Pr, i Pr, t Bu, cyclohexyl, more preferably Me, and HX is organic or inorganic acid, preferably HCl in the presence of a base, (iii) isolation of the obtained intermediate, preferably intermediate B, with formula where R is C 1 -C 6 alkyl, preferably Me, Et, Pr, i Pr, t Bu, cyclohexyl, more preferably Me and converting it to tadalafil via cyclisation with methylamine in the mixture of organic solvent with water, in a closed reaction vessel at temperature above the reflux temperature and at pressure of at least 0.1MPa, or in a closed vessel at an increased internal pressure and at a temperature above the boiling point of the employed solvent at normal atmospheric pressure, (iv) precipitation and isolation of the product, (v) optionally performing re-crystallization under increased pressure. (i) suspending D-tryptophan or a salt thereof or an ester of D-tryptophan with R-OH or a salt thereof and piperonal under acidic conditions in an organic solvent and heating the suspension in a closed reaction vessel above the reflux temperature and at pressure of at least 0.1MPa, or heating the suspension in a closed reaction vessel at an increased pressure at a temperature above the boiling point of the employed organic solvent at normal atmospheric pressure, (ii) chloroacylation of the "in situ" formed intermediate, preferably intermediate A which is a mixture of cis and trans isomer, with formula, where R is C 1 -C 6 alkyl, preferably Me, Et, Pr, i Pr, t Bu, cyclohexyl, more preferably Me, and HX is organic or inorganic acid, preferably HCl in the presence of a base, (iii) isolation of the obtained intermediate, preferably intermediate B, with formula where R is C 1 -C 6 alkyl, preferably Me, Et, Pr, i Pr, t Bu, cyclohexyl, more preferably Me and converting it to tadalafil via cyclisation with methylamine in the mixture of organic solvent with water, in a closed reaction vessel at temperature above the reflux temperature and at pressure of at least 0.1MPa, or in a closed vessel at an increased internal pressure and at a temperature above the boiling point of the employed solvent at normal atmospheric pressure, (iv) precipitation and isolation of the product, (v) optionally performing re-crystallization under increased pressure.
A hinge, comprising N sleeves that are jointed, wherein any two adjacent sleeves of the N sleeves are may sheathed together, and N is a positive integer greater than or equal to 2; wherein a first side wall of a first sleeve (201, 301, 1031) is provided with a first metal plate, a second side wall of a second sleeve (202, 303, 1032) is provided with a second metal plate, and the first sleeve and the second sleeve are two adjacent sleeves; wherein the first side wall is opposite to the second side wall and the first metal plate is opposite to the second metal plate, and the first metal plate and the second metal plate have overlapped orthogonal projection areas; and wherein when an electrical signal is applied to at least one of the first metal plate and the second metal plate, and the first sleeve and the second sleeve move relative to each other, the electrical signal between the first metal plate and the second metal plate changes. wherein a first side wall of a first sleeve (201, 301, 1031) is provided with a first metal plate, a second side wall of a second sleeve (202, 303, 1032) is provided with a second metal plate, and the first sleeve and the second sleeve are two adjacent sleeves; wherein the first side wall is opposite to the second side wall and the first metal plate is opposite to the second metal plate, and the first metal plate and the second metal plate have overlapped orthogonal projection areas; and wherein when an electrical signal is applied to at least one of the first metal plate and the second metal plate, and the first sleeve and the second sleeve move relative to each other, the electrical signal between the first metal plate and the second metal plate changes.
An automatic machine for producing reinforcement blanks, in particular of the type of reinforcement chairs, from reinforcement sections, consisting of moulding mechanisms, each comprising a stationary mandrel and a movable mandrel, actuated by a power mechanism, wherein the automatic machine comprises a moulding module comprising two outer moulding units (A, A') as well as a reinforcement section locking mechanism mounted on a support beam, wherein each of the outer moulding units (A, A') comprises a pair of mandrels with parallel longitudinal axes - an outer stationary mandrel and an outer movable mandrel, which are arranged relative to each other in such a way that they are capable of bending the ends of the reinforcement section in two mutually opposite directions, characterized in that the moulding module further comprises two inner moulding units (B, B'), wherein the reinforcement section locking mechanism is positioned between the two inner moulding units (B, B'), wherein each of the outer movable mandrels is fixed at one end to an arm and each of the outer stationary mandrel is fixed at the other end of the arm and connected by a shaft to a power mechanism to rotate the stationary mandrel around its axis, the power mechanism is mounted immovably on a mounting platform, which is fixed to the support beam, whereas each of the two inner moulding units (B, B') comprises a pair of mandrels with parallel longitudinal axes - a stationary mandrel and a movable mandrel, and the plane passing through the longitudinal axes of the two mandrels (6, 5) being perpendicular to the plane passing through the longitudinal axes of the outer mandrels (7, 8), each of the movable mandrels is fixed at one end to a second arm and the stationary mandrel is fixed at the other end of the arm and connected by a second shaft to a second power mechanism to rotate the stationary mandrel around its axis, the second power mechanism is attached immovably to a second mounting platform, which in turn is attached immovably to the support beam, wherein the mandrels of the inner and the outer moulding units (A, A' and B, B') are positioned in such a way that slits are formed between the stationary mandrels (7, 6) and the respective movable mandrels (8, 5) of the two moulding units (A, A' and B, B') to insert the reinforcement section; the automatic machine is provided with a controller and sensors for controlling the angle of bending of the reinforcement section are installed on each of the outer and the inner moulding units (A, A' and B, B') and on the reinforcement section locking mechanism, said sensors are connected to the controller of the automatic machine.
A shaver comprising: a handle with an elongated handgrip portion and a mounting portion, a shaver head, the shaver head being pivotally attached to the mounting portion, a removable cartridge, the cartridge comprising at least one blade, the cartridge being adapted to be attached to the shaver head and removed from the shaver head, a spring provided on the shaver head, the spring being adapted to attach the cartridge to the shaver head, and characterized in that the shaver further comprises a pusher, adapted to encounter the cartridge to release the cartridge from the shaver head, wherein the spring comprises at least one part which forms a loop. a handle with an elongated handgrip portion and a mounting portion, a shaver head, the shaver head being pivotally attached to the mounting portion, a removable cartridge, the cartridge comprising at least one blade, the cartridge being adapted to be attached to the shaver head and removed from the shaver head, a spring provided on the shaver head, the spring being adapted to attach the cartridge to the shaver head, and characterized in that the shaver further comprises a pusher, adapted to encounter the cartridge to release the cartridge from the shaver head, wherein the spring comprises at least one part which forms a loop.
A gripping device for securing a polymer tubing member to the skin of a medical patient, the gripping device comprising: an elongated base having a bottom and a top, the bottom comprising an interface member, and the top having a sloped apron surrounding a central table; a locking assembly comprising: an anchor block attached to the base, the anchor block having a first side and a second side; a locking strap having a root, a spine, a tip, and a plurality of fins, the root anchored to the first side of the anchor block such that a creased groove is defined by an interface between the first side and the locking strap, the creased groove disposed for seating a polymer tubing member, the fins disposed in pairs symmetrically about the spine, each fin having a trailing edge disposed substantially perpendicular to the spine, and a leading edge disposed at about a 40° angle in relation to the trailing edge; and a buckle having a root and a distal end, the root attached to the second side of the anchor block, and the root having a yoke such that an aperture is defined by the second side of the anchor block and the yoke. an elongated base having a bottom and a top, the bottom comprising an interface member, and the top having a sloped apron surrounding a central table; a locking assembly comprising: an anchor block attached to the base, the anchor block having a first side and a second side; a locking strap having a root, a spine, a tip, and a plurality of fins, the root anchored to the first side of the anchor block such that a creased groove is defined by an interface between the first side and the locking strap, the creased groove disposed for seating a polymer tubing member, the fins disposed in pairs symmetrically about the spine, each fin having a trailing edge disposed substantially perpendicular to the spine, and a leading edge disposed at about a 40° angle in relation to the trailing edge; and a buckle having a root and a distal end, the root attached to the second side of the anchor block, and the root having a yoke such that an aperture is defined by the second side of the anchor block and the yoke. an anchor block attached to the base, the anchor block having a first side and a second side; a locking strap having a root, a spine, a tip, and a plurality of fins, the root anchored to the first side of the anchor block such that a creased groove is defined by an interface between the first side and the locking strap, the creased groove disposed for seating a polymer tubing member, the fins disposed in pairs symmetrically about the spine, each fin having a trailing edge disposed substantially perpendicular to the spine, and a leading edge disposed at about a 40° angle in relation to the trailing edge; and a buckle having a root and a distal end, the root attached to the second side of the anchor block, and the root having a yoke such that an aperture is defined by the second side of the anchor block and the yoke.
A computer-implemented method for transmitting data blocks formed by multiple data fragments, in a wireless network comprising a plurality of nodes, the network having at least one routing path defined between a source node and a destination node and composed of a plurality of nodes such that three nodes at positions n/n+1/n+2 on the routing path define a child/parent/grandparent triad, the method comprising at least the following steps performed on a triad of child, parent and grandparent nodes: sending, from a child node, a child/parent probing message, referred to as a "ping" message, to a parent node; sending, from the parent node having received the "ping" message, a parent/grandparent probing message, referred to as a "yin" message, to a grandparent node if the parent node is available in a wait state; sending, from said grandparent node having received the "yin" message, a parent/grandparent probing response message, referred to as a "yang" message, to said parent node if the grandparent node is available; sending, from said parent node having received the "yang" message, a child/parent probing response message, referred to as a "pong" message, to said child node if the parent node is still available; and upon reception of the "pong" message by the child node, transmitting a data fragment from the child node to said parent node. sending, from a child node, a child/parent probing message, referred to as a "ping" message, to a parent node; sending, from the parent node having received the "ping" message, a parent/grandparent probing message, referred to as a "yin" message, to a grandparent node if the parent node is available in a wait state; sending, from said grandparent node having received the "yin" message, a parent/grandparent probing response message, referred to as a "yang" message, to said parent node if the grandparent node is available; sending, from said parent node having received the "yang" message, a child/parent probing response message, referred to as a "pong" message, to said child node if the parent node is still available; and upon reception of the "pong" message by the child node, transmitting a data fragment from the child node to said parent node.
A blind blade assembly for solar photovoltaic power generation, comprising: a blade frame provided with a mounting groove; a plurality of solar cell panels disposed in a longitudinal direction in the mounting groove; and fixing members for connecting electrodes between the solar cell panels and for fixing seams, wherein each of the fixing members is provided with fitting protrusions configured to be fitted into fitting holes provided at both sides of the mounting groove, characterized in that one side of the fixing member is further provided with a pressurization protrusion for pressurizing a connection point of the electrodes between the solar cell panels to connect the electrodes. a blade frame provided with a mounting groove; a plurality of solar cell panels disposed in a longitudinal direction in the mounting groove; and fixing members for connecting electrodes between the solar cell panels and for fixing seams, wherein each of the fixing members is provided with fitting protrusions configured to be fitted into fitting holes provided at both sides of the mounting groove, characterized in that one side of the fixing member is further provided with a pressurization protrusion for pressurizing a connection point of the electrodes between the solar cell panels to connect the electrodes.
An apparatus, comprising: a transmitter amplifier having an output terminal communicatively coupled to a transmission line to output a first set of radio frequency signals to an antenna; a receiver amplifier having an input terminal communicatively coupled to the transmission line to receive a second set of RF signals from the antenna; a passive network coupled between the transmitter amplifier and the receiver amplifier and comprising a series inductor, the passive network being configurable to cancel either a first reactance of a parasitic capacitance of the transmitter amplifier or second reactance of a parasitic capacitance of the receiver amplifier in the series inductor being configured to cancel said first and second reactances by impedance matching; and a switch coupled between the input terminal and a voltage reference to selectively configure the passive network to cancel either the first reactance or the second reactance. a transmitter amplifier having an output terminal communicatively coupled to a transmission line to output a first set of radio frequency signals to an antenna; a receiver amplifier having an input terminal communicatively coupled to the transmission line to receive a second set of RF signals from the antenna; a passive network coupled between the transmitter amplifier and the receiver amplifier and comprising a series inductor, the passive network being configurable to cancel either a first reactance of a parasitic capacitance of the transmitter amplifier or second reactance of a parasitic capacitance of the receiver amplifier in the series inductor being configured to cancel said first and second reactances by impedance matching; and a switch coupled between the input terminal and a voltage reference to selectively configure the passive network to cancel either the first reactance or the second reactance.
A secondary electrochemical battery sealing body with a charging indicator, the sealing body is configured to seal an opening portion of a battery case of a secondary electrochemical battery, and the sealing body comprises a negative electrode cap, a circuit board module and insulating washer, the negative electrode cap is located on an outermost side of the battery sealing body, and the circuit board module is located on an inner side of the negative electrode cap, and connected to the negative electrode cap via a connector; a charging indicator is disposed on a place, which corresponds to an edge of the negative electrode cap, on the circuit board module; a portion where the negative electrode cap and the circuit board module are connected is of a "C"-shaped annular structure, that is, a notch is formed on the edge of the negative electrode cap, the notch is a light transmission port of the charging indicator, the notch has a certain height but is not higher than the negative electrode cap, so that the charging indicator is exposed, and a position of the notch corresponds to a position of the charging indicator on the circuit board module; and the insulating washer is a flexible and elastic annular insulating washer, and the insulating washer is adapted to be arranged in gaps between the battery case and the circuit board module and between the battery case and the negative electrode cap, one segment of the insulating washer is adapted to press and fix the circuit board module, and an other segment is adapted to isolate the battery case from the negative electrode cap, the insulating washer further completely covers the light transmission port of the charging indicator, to be adapted for sealing the negative electrode cap the battery case and the circuit board module, and the insulating washer is made of a transparent light guiding material, so that light emitted by the charging indicator passes through the insulating washer, and the entire insulating washer is enabled to transmit the light.
A method for screening for an antagonist of a DNA-binding protein, the method comprising: i) providing a cell, wherein the cell comprises a test compound, a DNA-binding protein, and a reporter expression cassette that encodes a reporter expression product, wherein the reporter expression cassette comprises at least one binding site for the DNA-binding protein such that binding of the DNA-binding protein to the binding site inhibits expression of the reporter expression product; and ii) determining expression of the reporter expression product in the presence of the test compound; wherein an increase in expression of the reporter expression product in the presence of the test compound indicates that the test compound is capable of inhibiting DNA-binding activity of the DNA-binding protein, and wherein some or all of the binding site(s) are located in the transcribed sequence of the reporter expression cassette. i) providing a cell, wherein the cell comprises a test compound, a DNA-binding protein, and a reporter expression cassette that encodes a reporter expression product, wherein the reporter expression cassette comprises at least one binding site for the DNA-binding protein such that binding of the DNA-binding protein to the binding site inhibits expression of the reporter expression product; and ii) determining expression of the reporter expression product in the presence of the test compound; wherein an increase in expression of the reporter expression product in the presence of the test compound indicates that the test compound is capable of inhibiting DNA-binding activity of the DNA-binding protein, and wherein some or all of the binding site(s) are located in the transcribed sequence of the reporter expression cassette.
A power train for a high impedance load, comprising: an input EMC filter configured to be connected to a power supply; a converter connected to an output of the input EMC filter; and an output filter connected to the output of the converter, the output filter comprising three piezoelectric transformers (11a, 11b, 11c), one for each phase line (10a, 10b, 10c) of the converter, and respective inductors (13a, 13b, 13c), the respective inductors (13a, 13b, 13c) of the phase lines (10a, 10b, 10c) being connected at the inputs of the piezoelectric transformers (11a, 11b, 11c), wherein all three piezoelectric transformers (11a, 11b, 11c) share the same load (12"); and the load (12") is a power converter configured to regenerate switching energy. an input EMC filter configured to be connected to a power supply; a converter connected to an output of the input EMC filter; and an output filter connected to the output of the converter, the output filter comprising three piezoelectric transformers (11a, 11b, 11c), one for each phase line (10a, 10b, 10c) of the converter, and respective inductors (13a, 13b, 13c), the respective inductors (13a, 13b, 13c) of the phase lines (10a, 10b, 10c) being connected at the inputs of the piezoelectric transformers (11a, 11b, 11c), wherein all three piezoelectric transformers (11a, 11b, 11c) share the same load (12"); and the load (12") is a power converter configured to regenerate switching energy.
A positively-fitting, releasable component connection, with - a first component, - a male fixing element ∘ which has at least two spheres (3a, 3b) connected together and arranged coaxially with each other, and ∘ which projects from the first component, - a blocking element and - a second component which is arranged such that the male fixing element protrudes into a cutout in the second component, wherein the second component has at least one through-hole (5a, 5b) through which or into which the blocking element extends, which bears from the outside against the male fixing element and engages in a positive fit between the spheres (3a, 3b) and thereby opposes removal of the second component from the male fixing element, characterised in that the second component has a frame, with the at least one through-hole (5a, 5b) being provided in a first wall of the frame, through which through-hole the blocking element extends, and one through-hole (5a, 5b) in each case is provided in two opposing walls (4a, 4b) of the frame, through which or into which through-holes the blocking element extends. - a first component, - a male fixing element ∘ which has at least two spheres (3a, 3b) connected together and arranged coaxially with each other, and ∘ which projects from the first component, ∘ which has at least two spheres (3a, 3b) connected together and arranged coaxially with each other, and ∘ which projects from the first component, - a blocking element and - a second component which is arranged such that the male fixing element protrudes into a cutout in the second component,