A medical fluid management assembly (110b, 110c) comprising: a pneumatic manifold (120b, 120c) including a plurality of plates (122b, 124b, 126b, 130b, 122c, 124c, 126c, 130c) sealed together to form a plurality of pneumatic passageways (132b, 134b, 135b, 132c, 134c, 135c), a pneumatic valve chamber (136b, 138b, 136c, 138c) and a pneumatic pump chamber (140b, 140c) formed by at least one of the plates, the pneumatic valve chamber in pneumatic communication with at least one of the pneumatic passageways, and the pneumatic pump chamber in pneumatic communication with at least one of the pneumatic passageways; and a fluid manifold (200b, 200c) including a plurality of fluid pathways (204b, 206b, 204c, 206c), a fluid valve chamber (182b, 184b, 224c, 226c) and a fluid pump chamber (186b, 228c) formed by the fluid manifold, the fluid valve chamber in selective fluid communication with the fluid pump chamber and at least one of the fluid pathways, wherein (a) the pneumatic valve chamber (136b, 138b, 136c, 138c) and the fluid valve chamber (182b, 184b, 224c, 226c) are mated together to compress at least one flexible valve chamber membrane or a valve chamber area of at least one common flexible membrane (190, 192) and (b) the pneumatic pump chamber (140b, 140c) and the fluid pump chamber (186b, 228c) are mated together to compress at least one flexible pump membrane or a pump chamber area of the at least one common flexible membrane (190, 192), wherein at least one of (i) the pneumatic valve chamber (136b, 138b, 136c, 138c) extends outwardly from the at least one plate (126b, 126c), (ii) the pneumatic pump chamber (140b, 140c) extends outwardly from the at least one plate (126b, 126c), (iii) the fluid valve chamber (182b, 184b, 224c, 226c) extends outwardly from the fluid manifold (200b, 200c), or (iv) the fluid pump chamber (186b, 228c) extends outwardly from the fluid manifold (200b, 200c) so as to aid in compressing their respective at least one flexible membrane or at least one flexible membrane area (190, 192). a pneumatic manifold (120b, 120c) including a plurality of plates (122b, 124b, 126b, 130b, 122c, 124c, 126c, 130c) sealed together to form a plurality of pneumatic passageways (132b, 134b, 135b, 132c, 134c, 135c), a pneumatic valve chamber (136b, 138b, 136c, 138c) and a pneumatic pump chamber (140b, 140c) formed by at least one of the plates, the pneumatic valve chamber in pneumatic communication with at least one of the pneumatic passageways, and the pneumatic pump chamber in pneumatic communication with at least one of the pneumatic passageways; and a fluid manifold (200b, 200c) including a plurality of fluid pathways (204b, 206b, 204c, 206c), a fluid valve chamber (182b, 184b, 224c, 226c) and a fluid pump chamber (186b, 228c) formed by the fluid manifold, the fluid valve chamber in selective fluid communication with the fluid pump chamber and at least one of the fluid pathways, wherein (a) the pneumatic valve chamber (136b, 138b, 136c, 138c) and the fluid valve chamber (182b, 184b, 224c, 226c) are mated together to compress at least one flexible valve chamber membrane or a valve chamber area of at least one common flexible membrane (190, 192) and (b) the pneumatic pump chamber (140b, 140c) and the fluid pump chamber (186b, 228c) are mated together to compress at least one flexible pump membrane or a pump chamber area of the at least one common flexible membrane (190, 192), wherein at least one of (i) the pneumatic valve chamber (136b, 138b, 136c, 138c) extends outwardly from the at least one plate (126b, 126c), (ii) the pneumatic pump chamber (140b, 140c) extends outwardly from the at least one plate (126b, 126c), (iii) the fluid valve chamber (182b, 184b, 224c, 226c) extends outwardly from the fluid manifold (200b, 200c), or (iv) the fluid pump chamber (186b, 228c) extends outwardly from the fluid manifold (200b, 200c) so as to aid in compressing their respective at least one flexible membrane or at least one flexible membrane area (190, 192).