mhurhangee/ep-ind-claims huggingface dataset:
An apparatus for detecting and responding to changes in a subject in applying tumor treating fields to a region of interest of the subject's body corresponding to a tumor of the subject's body, the apparatus comprising one or more processors and memory accessible by the one or more processors and providing stored instructions that, when executed by the one or more processors, cause the apparatus to: alternately apply to the region of interest a first electric field between a first pair of locations (501, 504) of the subject's body and a second electric field between a second pair of locations (502, 503) of the subject's body; detect a change in the region of interest; record changes in the region of interest based on at least one of a posture change of the subject's body, a change in vital signs of the subject's body, a physiological change of the subject's body, a change in the voltage and/or current of the tumor treating fields or a change in the impedance of the subject's body over time; generate a habit model of the subject's body based on the recorded changes in the region of interest; cease applying the first and second electric fields; select, based on the habit model, a third pair of locations (505, 508) of the subject's body and a fourth pair of locations (506, 507) of the subject's body, the third and fourth pairs of locations (505, 508; 506, 507) being different than the first and second pairs of locations (501, 504; 502, 503); and alternately apply to the region of interest a third electric field between the third pair of locations (505, 508) and a fourth electric field between the fourth pair of locations (506, 507). alternately apply to the region of interest a first electric field between a first pair of locations (501, 504) of the subject's body and a second electric field between a second pair of locations (502, 503) of the subject's body; detect a change in the region of interest; record changes in the region of interest based on at least one of a posture change of the subject's body, a change in vital signs of the subject's body, a physiological change of the subject's body, a change in the voltage and/or current of the tumor treating fields or a change in the impedance of the subject's body over time; generate a habit model of the subject's body based on the recorded changes in the region of interest; cease applying the first and second electric fields; select, based on the habit model, a third pair of locations (505, 508) of the subject's body and a fourth pair of locations (506, 507) of the subject's body, the third and fourth pairs of locations (505, 508; 506, 507) being different than the first and second pairs of locations (501, 504; 502, 503); and alternately apply to the region of interest a third electric field between the third pair of locations (505, 508) and a fourth electric field between the fourth pair of locations (506, 507).
A method of transmitting an acknowledgement, ACK/non-acknowledgement, NACK, bit for transmit diversity in a wireless communication system, comprising steps of: generating a modulated symbol by modulating the ACK/NACK bit based on a binary phase shift keying, BPSK, scheme; generating code division multiplexed symbols by code division multiplexing the modulated symbol based on an orthogonal code having a spreading length of 4 and a cell-specific scrambling code; mapping the code division multiplexed symbols to each of a plurality of resource units spread in the frequency domain and two antennas based on a space frequency block coding, SFBC, scheme; and transmitting repeatedly in the frequency domain, for predetermined number of times, the mapped symbols through the two antennas based on a result of the mapping, wherein each of the plurality of resource units comprises a pair of neighboring subcarriers and two subsequent orthogonal frequency division multiplexing, OFDM, symbols, wherein the code division multiplexed symbols are divided into a first pair consisting of leading two symbols of the code division multiplexed symbols and a second pair of two ending symbols of the code division multiplexed symbols, and wherein the first pair and the second pair are mapped alternately to the two subsequent OFDM symbols in different transmissions in the frequency domain. generating a modulated symbol by modulating the ACK/NACK bit based on a binary phase shift keying, BPSK, scheme; generating code division multiplexed symbols by code division multiplexing the modulated symbol based on an orthogonal code having a spreading length of 4 and a cell-specific scrambling code; mapping the code division multiplexed symbols to each of a plurality of resource units spread in the frequency domain and two antennas based on a space frequency block coding, SFBC, scheme; and transmitting repeatedly in the frequency domain, for predetermined number of times, the mapped symbols through the two antennas based on a result of the mapping, wherein each of the plurality of resource units comprises a pair of neighboring subcarriers and two subsequent orthogonal frequency division multiplexing, OFDM, symbols, wherein the code division multiplexed symbols are divided into a first pair consisting of leading two symbols of the code division multiplexed symbols and a second pair of two ending symbols of the code division multiplexed symbols, and wherein the first pair and the second pair are mapped alternately to the two subsequent OFDM symbols in different transmissions in the frequency domain.
A wearable drug delivery device comprising: a housing; an adhesive layer disposed on an outer surface of the housing for attaching the drug delivery device to a patient's skin; a reservoir; a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF); a blunt cannula (54, 100) having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula (54, 100), the second end of the cannula (54, 100) is connected in fluid communication with the reservoir; and an introducer needle disposed in the cannula (54, 100) adapted for introducing the cannula (54, 100) into the patient's skin and subsequently withdrawing from the cannula (54, 100) prior to delivery of the drug product to the patient, characterized in that the cannula (54, 100) has at least one side port formed in the wall of the cannula (54, 100) at the first end, and wherein the cannula is initially within the housing and subsequently at least partially deployed from the housing in an operative state. a housing; an adhesive layer disposed on an outer surface of the housing for attaching the drug delivery device to a patient's skin; a reservoir; a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF); a blunt cannula (54, 100) having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula (54, 100), the second end of the cannula (54, 100) is connected in fluid communication with the reservoir; and an introducer needle disposed in the cannula (54, 100) adapted for introducing the cannula (54, 100) into the patient's skin and subsequently withdrawing from the cannula (54, 100) prior to delivery of the drug product to the patient, characterized in that the cannula (54, 100) has at least one side port formed in the wall of the cannula (54, 100) at the first end, and wherein the cannula is initially within the housing and subsequently at least partially deployed from the housing in an operative state.
A GNSS receiver for calculating a position from positioning signals transmitted with a first polarization by a plurality of GNSS transmitters, said receiver comprising a first signal acquisition element polarized according to said first polarization, the receiver being configured to process the signals received on said first signal acquisition element to calculate first pseudo range measurements, the receiver further comprising a second signal acquisition element polarized according to a second polarization different from the first polarization, the receiver being configured to process the signals received on said second signal acquisition element to calculate second pseudo range measurements and associated quality indicators, said receiver comprising a calculation circuit configured to: - select at least one of the second pseudo range measurements depending on the quality indicators, and compare said at least one second pseudo range measurement selected with the first pseudo range measurement acquired from a same GNSS transmitter, and - select at least three pseudo range measurements from the first pseudo range measurements based on the comparison results to calculate a position the receiver being characterised in that: - said quality indicators are computed only from said second pseudo range measurements, without considering the first pseudo range measurement acquired from a same GNSS transmitter, - the comparison is performed only between said at least one second pseudo range measurement selected and the first pseudo range measurement acquired from a same GNSS transmitter, and - selecting at least one of the second pseudo range measurements is done by selecting a defined number of second pseudo range measurements in a descending order of their quality indicators. - select at least one of the second pseudo range measurements depending on the quality indicators, and compare said at least one second pseudo range measurement selected with the first pseudo range measurement acquired from a same GNSS transmitter, and - select at least three pseudo range measurements from the first pseudo range measurements based on the comparison results to calculate a position - said quality indicators are computed only from said second pseudo range measurements, without considering the first pseudo range measurement acquired from a same GNSS transmitter, - the comparison is performed only between said at least one second pseudo range measurement selected and the first pseudo range measurement acquired from a same GNSS transmitter, and - selecting at least one of the second pseudo range measurements is done by selecting a defined number of second pseudo range measurements in a descending order of their quality indicators.
An oral care system comprising: a toothbrush defining a longitudinal axis (A-A) and including a head and a handle coupled to the head; a reservoir disposed in the toothbrush, the reservoir containing an oral care material; an applicator (300, 340) disposed in the toothbrush in fluid communication with the reservoir, the applicator (300, 340) operable to dispense the oral care material from the reservoir; a cover movably mounted on the toothbrush; wherein the cover is movable from a closed position in which the cover covers the applicator (300, 340) to an open position in which the applicator (300, 340) is exposed; wherein the cover is slidably movable on the toothbrush between the open and closed positions; and wherein the cover remains attached to the toothbrush between the closed and open positions; characterized in that the cover is axially movable along the longitudinal axis (A-A) between the closed and open positions. a toothbrush defining a longitudinal axis (A-A) and including a head and a handle coupled to the head; a reservoir disposed in the toothbrush, the reservoir containing an oral care material; an applicator (300, 340) disposed in the toothbrush in fluid communication with the reservoir, the applicator (300, 340) operable to dispense the oral care material from the reservoir; a cover movably mounted on the toothbrush; wherein the cover is movable from a closed position in which the cover covers the applicator (300, 340) to an open position in which the applicator (300, 340) is exposed; wherein the cover is slidably movable on the toothbrush between the open and closed positions; and wherein the cover remains attached to the toothbrush between the closed and open positions; characterized in that the cover is axially movable along the longitudinal axis (A-A) between the closed and open positions.
A power takeoff unit for taking off torque from a transmission of an automobile, comprising: a casing dividable into a first part (31,35) and a second part combined together; an inner shaft formed to be hollow to allow insertion of a shaft of the transmission and coupled with the transmission to rotate about an axis; an outer shaft independently rotatable and coaxial with the inner shaft; a clutch interposed between the inner shaft and the outer shaft and configured to drivingly connect the inner shaft with the outer shaft when the clutch is connected; an actuator configured to connect the clutch; an output shaft being so disposed as to intersect with, or be not parallel and not intersect with, the outer shaft and rotatable; and a gear set drivingly coupling the outer shaft with the output shaft, characterized in that the outer shaft and the output shaft are rotatably supported only by the first part (31,35), the clutch is rotatably supported by the second part, and the actuator is fixed to the second part, whereby the clutch and the actuator along with the second part are separable from the first part (31,35). a casing dividable into a first part (31,35) and a second part combined together; an inner shaft formed to be hollow to allow insertion of a shaft of the transmission and coupled with the transmission to rotate about an axis; an outer shaft independently rotatable and coaxial with the inner shaft; a clutch interposed between the inner shaft and the outer shaft and configured to drivingly connect the inner shaft with the outer shaft when the clutch is connected; an actuator configured to connect the clutch; an output shaft being so disposed as to intersect with, or be not parallel and not intersect with, the outer shaft and rotatable; and a gear set drivingly coupling the outer shaft with the output shaft, characterized in that the outer shaft and the output shaft are rotatably supported only by the first part (31,35), the clutch is rotatably supported by the second part, and the actuator is fixed to the second part, whereby the clutch and the actuator along with the second part are separable from the first part (31,35).
Press with an electric drive, in which the primary and secondary part are embodied as segments, wherein the drive includes: - a rotor connected to a shaft, said rotor comprising radial drive segments on its periphery and axial drive segments on at least one of its front faces, - a first stator, the drive segments of which form a radial segment motor with the radial drive segments of the rotor and - at least one second stator, the drive segments of which form at least one axial segment motor with the axial drive segments on the at least one front face of the rotor, characterised in that the radial segment motor or the at least one axial segment motor (21, 22) is partially equipped such that it is only wound in a subregion and is provided with magnets, and that the segment motor (20; 21, 22) of the drive, which is fully equipped, is used as a press motor to accelerate and brake the plunger between the forming regions and the partially equipped segment motor (20; 21, 22) for applying the additional forces for generating the required press force. - a rotor connected to a shaft, said rotor comprising radial drive segments on its periphery and axial drive segments on at least one of its front faces, - a first stator, the drive segments of which form a radial segment motor with the radial drive segments of the rotor and - at least one second stator, the drive segments of which form at least one axial segment motor with the axial drive segments on the at least one front face of the rotor, characterised in that the radial segment motor or the at least one axial segment motor (21, 22) is partially equipped such that it is only wound in a subregion and is provided with magnets, and that the segment motor (20; 21, 22) of the drive, which is fully equipped, is used as a press motor to accelerate and brake the plunger between the forming regions and the partially equipped segment motor (20; 21, 22) for applying the additional forces for generating the required press force.
An Alphabody polypeptide comprising an Alphabody having the general formula HRS1-L1-HRS2-L2-HRS3, wherein - each of HRS1, HRS2 and HRS3 is independently a heptad repeat sequence consisting of 2 to 7 consecutive heptad repeat units, at least 50% of all heptad a- and d-positions are occupied by isoleucine residues, each HRS starts and ends with an aliphatic or aromatic amino acid residue located at either a heptad a- or d-position, and HRS1, HRS2 and HRS3 together form a triple-stranded, alpha-helical, coiled coil structure; and - each of L1 and L2 is independently a linker fragment, which covalently connects HRS1 to HRS2 and HRS2 to HRS3, respectively; wherein said Alphabody specifically binds to a member of a cytokine - cytokine receptor or growth factor - growth factor receptor complex. - each of HRS1, HRS2 and HRS3 is independently a heptad repeat sequence consisting of 2 to 7 consecutive heptad repeat units, at least 50% of all heptad a- and d-positions are occupied by isoleucine residues, each HRS starts and ends with an aliphatic or aromatic amino acid residue located at either a heptad a- or d-position, and HRS1, HRS2 and HRS3 together form a triple-stranded, alpha-helical, coiled coil structure; and - each of L1 and L2 is independently a linker fragment, which covalently connects HRS1 to HRS2 and HRS2 to HRS3, respectively;
A pharmaceutical formulation which comprises from about 0.1 mg to about 100 mg of 4-{[(2R, 3S, 5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3- methoxy -benzoic Acid 1-[2-(2-methoxy-ethoxy)-ethoxycarbonyloxy]-ethyl ester of Compound A from about 10mM to about 100mM of a buffering agent, from about 25 mg to about 125 mg of a lyophilization bulking agent and an isotonicity builder having a pH of from about 5 to about 7, in a final reconstitution volume of 1ml.
A snowboard binding for securing a boot to a snowboard, the snowboard binding comprising a base configured to be mounted to the snowboard, the base having a base plate and a pair of side rails (26,28) that extend upwardly from the base plate along lateral sides of the base plate; and a high-back support pivotally secured to the pair of side rails (26, 28), the high-back support being pivotable between a stowed position in which the high-back support is disposed against the base and a use position in which the high-back support extends away from the base in an upright position, the high-back support having a leg engagement portion and is characterised in that the high-back support further comprises a pair of descending arms (64,66), each arm including a surface configured to engage the base plate of the base adjacent the side rails (26,28) to transfer a load from the leg engagement portion directly to the base plate 18 when the high-back support is in its use position.
Driving device, comprising a hand-held housing with a piston element for transferring energy to a fastening element to be driven accommodated in it, a preferably changeable propellant, a combustion chamber arranged between the propellant and the piston element, which extends preferably around a central axis, and a control element (8, 9, 10, 11, 12), by means of which a starting position of the piston element may be changed for changing the energy transferred from the propellant to the piston element in an adjustable way, in which the control element (8, 9, 10, 11, 12) has an operating part that may be swivelled around the central axis, characterised in that disassembly of the piston element may be locked through the operating part so that it may be released, in that a locking element locking the piston element may be unlocked in only one of several positions of the operating part.
A formulation for use in generating an adhesion barrier, which is a biodegradable film, wherein the formulation comprises: a plurality of dry particles comprising a polymer combination, wherein the polymer combination comprises at least one non-water soluble biodegradable polymer selected from the group consisting of 50/50 PLGA, and 70/30 PLGA, and at least one water soluble polymer selected from the group consisting of PEG, PEG block copolymers, sucrose, starch, alginate, PVP, PVA and any combination thereof; wherein the formulation is capable of absorbing moisture of a tissue, thus forming, by swelling and overlapping of the particles, a film over a surface of an internal body tissue when deposited on the surface, the film being capable of reducing or preventing adhesion of the surface to other body tissue(s). a plurality of dry particles comprising a polymer combination, wherein the polymer combination comprises at least one non-water soluble biodegradable polymer selected from the group consisting of 50/50 PLGA, and 70/30 PLGA, and at least one water soluble polymer selected from the group consisting of PEG, PEG block copolymers, sucrose, starch, alginate, PVP, PVA and any combination thereof;
Compound of formula wherein R is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted; R' is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted; R" is a group of formula -CH 2 OH or n is 0, 1, 2, 3, 4 or 5; Y is independently optionally substituted alkyl, heteroalkyl, halogen, CN, NO 2 or OH; or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof. R is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted; R' is H or an alkyl, alkenyl, alkynyl, CO-alkyl or heteroalkyl group, all of which may optionally be substituted; R" is a group of formula -CH 2 OH or n is 0, 1, 2, 3, 4 or 5; Y is independently optionally substituted alkyl, heteroalkyl, halogen, CN, NO 2 or OH; or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof.
A switching device for a motor vehicle with a gear lever and an electrical drive element for limiting an actuation path of the gear lever by means of a limiting element driven by the drive element, wherein a driven position change of the gear lever is provided, wherein, for the driven position change of the gear lever, a drive element is provided that is different from the electrical drive element of the limiting element, characterised in that a retaining element is provided for retaining a gear lever position against the force of the drive element for the position change of the gear lever, and in that the retaining element for retaining the gear lever position against the force of the drive element for the position change of the gear lever is electrically releasable when actuated.
An anti-angiogenesis agent for use in treating glioma or breast cancer, wherein the anti-angiogenesis agent is tetraiodothyroacetic acid (TETRAC) or triiodothyroacetic acid (TRIAC), or combinations thereof, and wherein the anti-angiogenesis agent acts at the cell surface to inhibit a pro-angiogenesis agent and wherein the anti-angiogenesis agent is conjugated to a polymer via a covalent bond.