Apparatus for facilitating delivery of a substance through skin of a subject, comprising: a handle comprising an eject button; and a cartridge, removably coupled to the handle, the cartridge comprising one or more electrodes in an electrode-containing portion and a patch comprising the substance, the electrodes adapted to be applied to a region of the skin; and characterized in that the apparatus further comprises: a control unit, adapted to apply a current between two or more of the electrodes when the electrodes are in contact with the region of the skin, and adapted to configure the current to cause ablation of stratum corneum in the region, so as to facilitate passage of the substance from the patch through the ablated stratum corneum; the patch further comprising: a substance-containing portion or pad, and a protective cover; the protective cover comprising a tab adapted to be coupled to the cartridge; and an adhesive strip coupled to an edge of the patch, and adapted to adhere to the skin of the subject at a time when the one or more electrodes are applied to the skin; and an adhesive border; and wherein the patch is adapted such that moving the handle away from the treated region of the skin pulls on the tab of the protective cover separating the cover from the patch, while simultaneously causing the patch to be folded over the treated region of the skin, because one side of the patch is held to the skin by the adhesive strip, so that the cover eventually completely separates from the patch and the substance-containing portion is held in place on the treated region of the skin by the adhesive border on the patch; and wherein slight pressure applied to the patch by the user causes the patch on the skin to be securely seated and when the pressure is applied using a finger there is no contamination of the treated region of skin, as only the backside of the patch is touched; and wherein the electrode-containing portion and cover are ejected from the handle by activation of the eject button and are subsequently discarded. a handle comprising an eject button; and a cartridge, removably coupled to the handle, the cartridge comprising one or more electrodes in an electrode-containing portion and a patch comprising the substance, the electrodes adapted to be applied to a region of the skin; and characterized in that the apparatus further comprises: a control unit, adapted to apply a current between two or more of the electrodes when the electrodes are in contact with the region of the skin, and adapted to configure the current to cause ablation of stratum corneum in the region, so as to facilitate passage of the substance from the patch through the ablated stratum corneum; the patch further comprising: a substance-containing portion or pad, and a protective cover; the protective cover comprising a tab adapted to be coupled to the cartridge; and an adhesive strip coupled to an edge of the patch, and adapted to adhere to the skin of the subject at a time when the one or more electrodes are applied to the skin; and a control unit, adapted to apply a current between two or more of the electrodes when the electrodes are in contact with the region of the skin, and adapted to configure the current to cause ablation of stratum corneum in the region, so as to facilitate passage of the substance from the patch through the ablated stratum corneum; the patch further comprising: a substance-containing portion or pad, and a protective cover; the protective cover comprising a tab adapted to be coupled to the cartridge; and an adhesive strip coupled to an edge of the patch, and adapted to adhere to the skin of the subject at a time when the one or more electrodes are applied to the skin; and a substance-containing portion or pad, and a protective cover; the protective cover comprising a tab adapted to be coupled to the cartridge; and an adhesive strip coupled to an edge of the patch, and adapted to adhere to the skin of the subject at a time when the one or more electrodes are applied to the skin; and an adhesive border; and wherein the patch is adapted such that moving the handle away from the treated region of the skin pulls on the tab of the protective cover separating the cover from the patch, while simultaneously causing the patch to be folded over the treated region of the skin, because one side of the patch is held to the skin by the adhesive strip, so that the cover eventually completely separates from the patch and the substance-containing portion is held in place on the treated region of the skin by the adhesive border on the patch; and wherein slight pressure applied to the patch by the user causes the patch on the skin to be securely seated and when the pressure is applied using a finger there is no contamination of the treated region of skin, as only the backside of the patch is touched; and wherein the electrode-containing portion and cover are ejected from the handle by activation of the eject button and are subsequently discarded.