A method for preparing macrolide particulates, wherein the method is for preparing macrolide particulates having a size of 10 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) dissolving and/or dispersing macrolide in a liquid to form a composition; (b) forming a supersaturated composition; (c) providing sonication in the composition; (d) evaporating the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake, (e) ceasing mechanical stirring prior to complete evaporation of the solvent from the composition; and (f) after step (e), removing remaining solvent from the composition to provide the macrolide particulates; or wherein the method is for preparing macrolide particulates having a size of 20 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) preparing a composition comprising macrolide, a first, optionally aromatic, solvent, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile, wherein the composition is characterized as providing a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates; or wherein the method is for preparing macrolide particulates having a size of 20 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) preparing a composition comprising macrolide, a first solvent that is aromatic, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates. wherein the method is for preparing macrolide particulates having a size of 10 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) dissolving and/or dispersing macrolide in a liquid to form a composition; (b) forming a supersaturated composition; (c) providing sonication in the composition; (d) evaporating the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake, (e) ceasing mechanical stirring prior to complete evaporation of the solvent from the composition; and (f) after step (e), removing remaining solvent from the composition to provide the macrolide particulates; or (a) dissolving and/or dispersing macrolide in a liquid to form a composition; (b) forming a supersaturated composition; (c) providing sonication in the composition; (d) evaporating the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake, (e) ceasing mechanical stirring prior to complete evaporation of the solvent from the composition; and (f) after step (e), removing remaining solvent from the composition to provide the macrolide particulates; wherein the method is for preparing macrolide particulates having a size of 20 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) preparing a composition comprising macrolide, a first, optionally aromatic, solvent, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile, wherein the composition is characterized as providing a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates; or (a) preparing a composition comprising macrolide, a first, optionally aromatic, solvent, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile, wherein the composition is characterized as providing a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates; wherein the method is for preparing macrolide particulates having a size of 20 μm or less, wherein the macrolide is in crystalline form, comprising steps of: (a) preparing a composition comprising macrolide, a first solvent that is aromatic, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates. (a) preparing a composition comprising macrolide, a first solvent that is aromatic, and a second solvent selected from the group consisting of an alcohol, acetone, and acetonitrile; and (b) evaporating the first and second solvents from the composition to form a slurry or a wet cake and mechanically stirring the slurry or wet cake to provide the macrolide particulates.