A compound of Formula I, or a pharmaceutically acceptable salt thereof, for use in treating tendinopathy in a subject, wherein the subject is human wherein: R 1, R 2 and R 4 are independently selected from the group consisting of H, C 1-9 alkyl, halide, -N(R 10) 2, -XR 10, CN, -OCF 3 and -CF 3; R 3 is selected from the group consisting of carbocyclylR 6, heterocyclylR 6, arylR 6 and heteroarylR 6; R 5 is selected from the group consisting of -(C 1-9 alkyl) n carbocyclylR 7, -(C 1-9 alkyl) n heterocyclylR 7, -(C 1-9 alkyl) n arylR 7 and -(C 1-9 alkyl) n heteroarylR 7; each R 6 is 1-5 substituents each selected from the group consisting of H, C 1-9 alkyl, halide, amino, -OCF 3, -CF 3, -CN, -XR 10, -(C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8, -(C 1-9 alkyl) n heteroarylR 8, -C(=O)R 11, - N(R 10)C(=O)R 11, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)SO 2 R 11 and -SO 2 R 11; each R 7 is 1-5 substituents each selected from the group consisting of H, C 1-9 alkyl, halide, amino, -OCF 3, -CF 3, -CN, -XR 10, -(C 1-9 alkyl) n carbocyclylR 9, -(C 1-9 alkyl) n heterocyclylR 9, -(C 1-9 alkyl) n arylR 9, -(C 1-9 alkyl) n heteroarylR 9, -C(=O)R 11, - N(R 10)C(=O)R 11, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)SO 2 R 11 and -SO 2 R 11; each R 8 is 1-5 substituents each selected from the group consisting of H, C 1-3 alkyl, halide, amino, OCF 3, -CF 3 -CN, -XR 12, -C(=O)R 13, -N(R 12)C(=O)R 13, -(C 1-9 alkyl) n N(R 12) 2, - (C 1-9 alkyl) n N(R 12)SO 2 R 13 and -SO 2 R 13; each R 9 is 1-5 substituents each selected from the group consisting of H, C 1-3 alkyl, halide, amino, -OCF 3, -CF 3 -CN, -XR 12, -C(=O)R 13, -N(R 12)C(=O)R 13, -(C 1-9 alkyl) n N(R 12) 2, - (C 1-9 alkyl) n N(R 12)SO 2 R 13 and -SO 2 R 13; each R 10 is independently selected from the group consisting of H, C 1-9 alkyl, -(C 1-9 alkyl) n N(R 14) 2, -(C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8 and -(C 1-9 alkyl) n heteroarylR 8; each R 11 is independently selected from the group consisting of C 1-9 alkyl, -N(R 14) 2, - (C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8 and -(C 1-9 alkyl) n heteroarylR 8; each R 12 is independently selected from the group consisting of H, C 1-9 alkyl, -(C 1-9 alkyl) n N(R 14) 2, -(C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; each R 13 is independently selected from the group consisting of C 1-9 alkyl, -N(R 14) 2, - (C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; each R 14 is independently selected from the group consisting of H, C 1-3 alkyl, carbocyclyl and aryl; each X is selected from the group consisting of a bond, -O- and -S-; and each n is 0 or 1. R 1, R 2 and R 4 are independently selected from the group consisting of H, C 1-9 alkyl, halide, -N(R 10) 2, -XR 10, CN, -OCF 3 and -CF 3; R 3 is selected from the group consisting of carbocyclylR 6, heterocyclylR 6, arylR 6 and heteroarylR 6; R 5 is selected from the group consisting of -(C 1-9 alkyl) n carbocyclylR 7, -(C 1-9 alkyl) n heterocyclylR 7, -(C 1-9 alkyl) n arylR 7 and -(C 1-9 alkyl) n heteroarylR 7; each R 6 is 1-5 substituents each selected from the group consisting of H, C 1-9 alkyl, halide, amino, -OCF 3, -CF 3, -CN, -XR 10, -(C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8, -(C 1-9 alkyl) n heteroarylR 8, -C(=O)R 11, - N(R 10)C(=O)R 11, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)SO 2 R 11 and -SO 2 R 11; each R 7 is 1-5 substituents each selected from the group consisting of H, C 1-9 alkyl, halide, amino, -OCF 3, -CF 3, -CN, -XR 10, -(C 1-9 alkyl) n carbocyclylR 9, -(C 1-9 alkyl) n heterocyclylR 9, -(C 1-9 alkyl) n arylR 9, -(C 1-9 alkyl) n heteroarylR 9, -C(=O)R 11, - N(R 10)C(=O)R 11, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)SO 2 R 11 and -SO 2 R 11; each R 8 is 1-5 substituents each selected from the group consisting of H, C 1-3 alkyl, halide, amino, OCF 3, -CF 3 -CN, -XR 12, -C(=O)R 13, -N(R 12)C(=O)R 13, -(C 1-9 alkyl) n N(R 12) 2, - (C 1-9 alkyl) n N(R 12)SO 2 R 13 and -SO 2 R 13; each R 9 is 1-5 substituents each selected from the group consisting of H, C 1-3 alkyl, halide, amino, -OCF 3, -CF 3 -CN, -XR 12, -C(=O)R 13, -N(R 12)C(=O)R 13, -(C 1-9 alkyl) n N(R 12) 2, - (C 1-9 alkyl) n N(R 12)SO 2 R 13 and -SO 2 R 13; each R 10 is independently selected from the group consisting of H, C 1-9 alkyl, -(C 1-9 alkyl) n N(R 14) 2, -(C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8 and -(C 1-9 alkyl) n heteroarylR 8; each R 11 is independently selected from the group consisting of C 1-9 alkyl, -N(R 14) 2, - (C 1-9 alkyl) n carbocyclylR 8, -(C 1-9 alkyl) n heterocyclylR 8, -(C 1-9 alkyl) n arylR 8 and -(C 1-9 alkyl) n heteroarylR 8; each R 12 is independently selected from the group consisting of H, C 1-9 alkyl, -(C 1-9 alkyl) n N(R 14) 2, -(C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; each R 13 is independently selected from the group consisting of C 1-9 alkyl, -N(R 14) 2, - (C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; each R 14 is independently selected from the group consisting of H, C 1-3 alkyl, carbocyclyl and aryl; each X is selected from the group consisting of a bond, -O- and -S-; and each n is 0 or 1.