A filtration assembly comprising: i) a hyperfiltration assembly comprising: a) a high pressure vessel comprising a feed port, concentrate port and permeate port; b) a plurality of serially arranged spiral wound hyperfiltration membrane modules located within the high pressure vessel and each comprising at least one membrane envelop wound around a permeate tube forming a permeate pathway to the permeate port; ii) a bioreactor assembly comprising: a) a low pressure vessel comprising a first and second port, b) a plurality of spiral wound bioreactors located within the low pressure vessel with each bioreactor comprising a flat sheet having two opposing bio-growth surfaces (56, 56') and a feed spacer spirally wound about an axis to form a cylindrical outer periphery extending along axis from a first end to a second end with an inlet scroll face located near the first end and an outlet scroll face located near the second end and a center conduit, wherein the center conduits of the bioreactors are in fluid communication with each other and the second port; and iii) a fluid flow pathway adapted for fluid connection with a fluid feed source and passing: a) into the first port of the low pressure vessel, through the inlets of the scroll faces and out of the outlet scroll faces of the bioreactors, through the center conduits and out the second port of the low pressure vessel, and b) into the feed port of the high pressure vessel, through the spiral wound hyperfiltration membrane modules and out of the concentrate port and permeate port. i) a hyperfiltration assembly comprising: a) a high pressure vessel comprising a feed port, concentrate port and permeate port; b) a plurality of serially arranged spiral wound hyperfiltration membrane modules located within the high pressure vessel and each comprising at least one membrane envelop wound around a permeate tube forming a permeate pathway to the permeate port; a) a high pressure vessel comprising a feed port, concentrate port and permeate port; b) a plurality of serially arranged spiral wound hyperfiltration membrane modules located within the high pressure vessel and each comprising at least one membrane envelop wound around a permeate tube forming a permeate pathway to the permeate port; ii) a bioreactor assembly comprising: a) a low pressure vessel comprising a first and second port, b) a plurality of spiral wound bioreactors located within the low pressure vessel with each bioreactor comprising a flat sheet having two opposing bio-growth surfaces (56, 56') and a feed spacer spirally wound about an axis to form a cylindrical outer periphery extending along axis from a first end to a second end with an inlet scroll face located near the first end and an outlet scroll face located near the second end and a center conduit, wherein the center conduits of the bioreactors are in fluid communication with each other and the second port; and a) a low pressure vessel comprising a first and second port, b) a plurality of spiral wound bioreactors located within the low pressure vessel with each bioreactor comprising a flat sheet having two opposing bio-growth surfaces (56, 56') and a feed spacer spirally wound about an axis to form a cylindrical outer periphery extending along axis from a first end to a second end with an inlet scroll face located near the first end and an outlet scroll face located near the second end and a center conduit, wherein the center conduits of the bioreactors are in fluid communication with each other and the second port; and iii) a fluid flow pathway adapted for fluid connection with a fluid feed source and passing: a) into the first port of the low pressure vessel, through the inlets of the scroll faces and out of the outlet scroll faces of the bioreactors, through the center conduits and out the second port of the low pressure vessel, and b) into the feed port of the high pressure vessel, through the spiral wound hyperfiltration membrane modules and out of the concentrate port and permeate port. a) into the first port of the low pressure vessel, through the inlets of the scroll faces and out of the outlet scroll faces of the bioreactors, through the center conduits and out the second port of the low pressure vessel, and b) into the feed port of the high pressure vessel, through the spiral wound hyperfiltration membrane modules and out of the concentrate port and permeate port.