Process for the manufacturing of compound of formula comprising the step of reacting compound of formula (II-A) and compound of formula (II-B) in the presence of at least one chiral compound of formula (II-C) and of at least one urea compound of formula (X-A) or at least one thiourea compound of formula (X-B) wherein R 1, R 3 and R 4 are independently from each other hydrogen or methyl groups; R 2 and R 2' represents hydrogen or a phenol protection group; R 5 represents either a linear or branched completely saturated C 6-25 -alkyl group or a linear or branched C 6-25 -alkyl group comprising at least one carbon-carbon double bond; Y 1 represents either CH 2 Y 2 or wherein R 6 represents a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group; Y 2 represents either OH or OR 7 or NHR 7 or NHCOOR 7 or wherein R 7 represents either a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group and the dotted line(s) represents the bond(s) by which the corresponding substituent is bound to the rest of formula (II-C); and wherein * represents the chiral centre of the chiral isomer of formula; and wherein Z 1 represents either H or a group CH 2 Z 4 or an aryl group; Z 2 represents either H or a group CH 2 Z 4 or an aryl group; Z 3 represents either H or a group CH 2 Z 4 or an aryl group; wherein Z 4 represents H or an C 1 -C 6 alkyl group; with the proviso that if Z 1 is different from H, that Z 2 represents H. wherein R 1, R 3 and R 4 are independently from each other hydrogen or methyl groups; R 2 and R 2' represents hydrogen or a phenol protection group; R 5 represents either a linear or branched completely saturated C 6-25 -alkyl group or a linear or branched C 6-25 -alkyl group comprising at least one carbon-carbon double bond; Y 1 represents either CH 2 Y 2 or wherein R 6 represents a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group; Y 2 represents either OH or OR 7 or NHR 7 or NHCOOR 7 or wherein R 7 represents either a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group wherein R 6 represents a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group; Y 2 represents either OH or OR 7 or NHR 7 or NHCOOR 7 or wherein R 7 represents either a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group wherein R 7 represents either a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group a linear or branched C 1-12 -alkyl group which optionally further comprises at least one aromatic group and/or C=O and/or NH and/or NH 2 group or an aryl group or a substituted aryl group or a heteroaryl group or a substituted heteroaryl group and the dotted line(s) represents the bond(s) by which the corresponding substituent is bound to the rest of formula (II-C); and wherein * represents the chiral centre of the chiral isomer of formula; and wherein Z 1 represents either H or a group CH 2 Z 4 or an aryl group; Z 2 represents either H or a group CH 2 Z 4 or an aryl group; Z 3 represents either H or a group CH 2 Z 4 or an aryl group; wherein Z 4 represents H or an C 1 -C 6 alkyl group; wherein Z 4 represents H or an C 1 -C 6 alkyl group; with the proviso that if Z 1 is different from H, that Z 2 represents H.