mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing a powder formulation for inhalation for use in a dry powder inhaler, said powder formulation comprising: a carrier, comprising: (a) a fraction of coarse particles of a physiologically acceptable carrier having a particle size of at least 60 micron; and optionally (b) a fraction of fine particles comprising a physiologically acceptable excipient, wherein at least 90% of all said fine particles has a volume diameter lower than 15 micron, micronized particles of glycopyrronium bromide, an inhaled corticosteroid, and optionally a long-acting β 2 -agonist (LABA), as active ingredients, wherein said process comprises: (i) preparing by co-milling microparticles consisting of glycopyrronium bromide and a first part of the ICS in a ratio ranging from 80:20 to 70:30 by weight, wherein the volume diameter of said microparticles is not higher than 15 micron; (ii) mixing the carrier, the remaining part of said ICS, and optionally the long-acting β 2 -agonist, to obtain a first mixture; and (iii) adding the co-milled microparticles obtained in step (i) to the first mixture obtained in step (ii), to obtain a second, final, mixture. a carrier, comprising: (a) a fraction of coarse particles of a physiologically acceptable carrier having a particle size of at least 60 micron; and optionally (b) a fraction of fine particles comprising a physiologically acceptable excipient, wherein at least 90% of all said fine particles has a volume diameter lower than 15 micron, (a) a fraction of coarse particles of a physiologically acceptable carrier having a particle size of at least 60 micron; and optionally (b) a fraction of fine particles comprising a physiologically acceptable excipient, wherein at least 90% of all said fine particles has a volume diameter lower than 15 micron, micronized particles of glycopyrronium bromide, an inhaled corticosteroid, and optionally a long-acting β 2 -agonist (LABA), as active ingredients, (i) preparing by co-milling microparticles consisting of glycopyrronium bromide and a first part of the ICS in a ratio ranging from 80:20 to 70:30 by weight, wherein the volume diameter of said microparticles is not higher than 15 micron; (ii) mixing the carrier, the remaining part of said ICS, and optionally the long-acting β 2 -agonist, to obtain a first mixture; and (iii) adding the co-milled microparticles obtained in step (i) to the first mixture obtained in step (ii), to obtain a second, final, mixture.
A suspension aerosol pharmaceutical composition comprising fluticasone or a pharmaceutically acceptable derivative thereof, HFA-134a and polyvinylpyrrolidone; wherein the concentration of the polyvinylpyrrolidone is from 0.00001 to 10% w/w; and wherein the fluticasone or a pharmaceutically acceptable derivative thereof is a compound of formula: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein R is hydrogen or -COR x, and wherein R x is an optionally substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl group.
Locking device for locking at least one machine on a transport vehicle, wherein the machine comprises at least one locking stop and wherein the machine to be locked is designed as a vehicle comprising at least one front axle and one rear axle, characterized in that the locking device comprises at least one carrier unit connected to the transport vehicle, a securing element which can be connected to the carrier unit, and the at least one locking stop connected to the machine, and wherein the at least one locking stop can be coupled in form-locking manner with the securing element, wherein, for each vehicle axle (8, 9) of the vehicle to be locked, a carrier unit is positioned in each case on the transport vehicle, and each carrier unit has in each case in its external areas one or more recesses (16, 20).
A power system, comprising: a turbocharger; an oil sump; a supply passage positioned fluidly between the turbocharger and the oil sump, the supply passage configured to supply oil to the turbocharger; a return passage positioned fluidly between the turbocharger and oil sump, the return passage being configured to return oil from the turbocharger to the oil sump; characterized by a turbocharger bypass passage positioned fluidly between the supply passage and the return passage, the turbocharger bypass passage comprising a valve, the valve being configured to be in a closed position when the turbocharger is in a normal operating mode, and the valve being configured to be in an open position when the turbocharger is in a failure mode. a turbocharger; an oil sump; a supply passage positioned fluidly between the turbocharger and the oil sump, the supply passage configured to supply oil to the turbocharger; a return passage positioned fluidly between the turbocharger and oil sump, the return passage being configured to return oil from the turbocharger to the oil sump; characterized by a turbocharger bypass passage positioned fluidly between the supply passage and the return passage, the turbocharger bypass passage comprising a valve, the valve being configured to be in a closed position when the turbocharger is in a normal operating mode, and the valve being configured to be in an open position when the turbocharger is in a failure mode.
Refrigeration appliance, in particular a household refrigeration appliance, having at least two appliance doors (1,3), which are disposed one above the other in the appliance height direction (z) and can each be used to close cooling compartments of the refrigeration appliance, and having operating and display elements (16, 18) for actuating the refrigeration appliance, wherein the operating and display elements (16, 18) of the refrigeration appliance are disposed on the lower end of the upper appliance door, in particular on its appliance front, and the upper appliance door terminates at its lower end with a lower narrow door face that runs horizontally, on which a lower door termination strip is provided, wherein the lower door termination strip of the upper appliance door has a downwardly exposed visible surface, characterised in that the lower door termination strip has a mounting recess set back therefrom, into which mounting recess an electronic control system housing is inserted and that the door termination strip is approximately stepped in the cross section and that the mounting recess opens forwards in the depth direction.
Structural unit having a first structural element, having a second structural element and having a connecting unit which is intended for transmitting torque from the first structural element to the second structural element during an operating process, wherein the first structural element is a shaft or a hub or a gearwheel, wherein the first structural element has at least one groove into which at least a component of the connecting unit engages, wherein the connecting unit has two, three, four, five or more integrally formed components, characterized in that the connecting unit consists of at least 90 percent technical ceramic by mass, and the connecting unit fastens the second structural element to the first structural element in a form-fitting manner in relation to a circumferential direction of the first structural element, and the first and second structural elements are displaceable relative to one another in a longitudinal direction of the first structural element, and at least one of the components is of roller-like form.
Device for holding an added part against a carrying part in a fitted position, and in a position for withdrawal in which the added part is spaced further away from the carrying part than in the fitted position, having a U-shaped insertable clip which, when used as intended, is arranged in an opening made in the carrying part, and having a plug-on part which, when positioned as intended, is so connected to the insertable clip and to the added part as to be displaceable, the plug-on part, when the added part is in the fitted position, being arranged in a supporting arrangement (16, 19, 20) formed on the insertable clip and being secured against removal from the supporting arrangement (16, 19, 20) in the direction away from the carrying part, the supporting arrangement (16, 19, 20), when the added part is in the position for withdrawal, setting up a resistance to the plug-on part being shifted out of engagement with the supporting arrangement (16, 19, 20) in the direction of the carrying part, the plug-on part being out of engagement with the insertable clip and able to be removed therefrom once the resistance has been overcome, and the insertable clip having two clip arms (2, 3), characterised in that the plug-on part has two mutually parallel side-walls (23, 24) which are connected together by two connecting cross-pieces (25, 26) which define an entry opening, in that the supporting arrangement (16, 19, 20) has two support tongues which are formed on respective ones of the clip arms (2, 3) of the insertable clip, which are arranged in apertures and which are positioned to point towards one another and in the direction of the free ends of the clip arms (2, 3), and in that the plug-on part has, formed on its side-walls (23, 24), fixing tongues which, in the fitted position, while the clip arms (2, 3) are enclosed by means of the connecting cross-pieces (25, 26), rest on supporting portions of the supporting tongues in a position between the supporting tongues and top lips of edge portions (19, 20) of the insertable clip, and which are sized to slide out of the apertures.
A scanning apparatus (110, 600) comprising: a fold mirror (650, 1050) to reflect light; a first scan mirror positioned to receive light from the fold mirror (650, 1050) and provide a light beam scanned in a first dimension, wherein the first scan mirror is a MEMS scan mirror; a second scan mirror (630, 1032, 1132, 1332); and a micro-electromechanical system - MEMS - device formed out of a common substrate (610, 1000), the MEMS device comprising a scanning platform (1030, 1130, 1330) and flexures that couple the scanning platform (1030, 1130, 1330) to an outer portion of the common substrate (610, 1000), characterized in that the second scan mirror (630, 1032, 1132, 1332) is positioned to receive the light beam from the first scan mirror and to provide a light beam scanned in a second dimension, the second scan mirror (630, 1032, 1132, 1332) is formed by a reflective face of the scanning platform (1030, 1130, 1330), or is affixed or bonded to the scanning platform (1030, 1130, 1330), and the fold mirror (650, 1050) is formed by a reflective portion of or coating on the outer portion of the common substrate (610, 1000), or is a reflective element affixed or bonded to the outer portion of the common substrate (610, 1000). a fold mirror (650, 1050) to reflect light; a first scan mirror positioned to receive light from the fold mirror (650, 1050) and provide a light beam scanned in a first dimension, wherein the first scan mirror is a MEMS scan mirror; a second scan mirror (630, 1032, 1132, 1332); and a micro-electromechanical system - MEMS - device formed out of a common substrate (610, 1000), the MEMS device comprising a scanning platform (1030, 1130, 1330) and flexures that couple the scanning platform (1030, 1130, 1330) to an outer portion of the common substrate (610, 1000), characterized in that the second scan mirror (630, 1032, 1132, 1332) is positioned to receive the light beam from the first scan mirror and to provide a light beam scanned in a second dimension, the second scan mirror (630, 1032, 1132, 1332) is formed by a reflective face of the scanning platform (1030, 1130, 1330), or is affixed or bonded to the scanning platform (1030, 1130, 1330), and the fold mirror (650, 1050) is formed by a reflective portion of or coating on the outer portion of the common substrate (610, 1000), or is a reflective element affixed or bonded to the outer portion of the common substrate (610, 1000).
A process for producing an electrolyte polymer for polymer electrolyte fuel cells made of a perfluorinated polymer having sulfonic groups, characterized in that a perfluorinated polymer having precursor groups for sulfonic groups, is subjected to heat treatment for at least 0.1 hour at a temperature of from 200 to 300°C under a reduced pressure of at most 0.02 MPa and then contacted with fluorine gas at a temperature of from 150 to 200°C and further subjected to hydrolysis and treatment for conversion to an acid form, to convert the precursor groups to sulfonic groups.
Hand-held power tool, in particular drill, hammer drill or screwdriver, having a drive means, disposed in a housing, for driving a tool received in a tool receiving region, wherein the hand-held power tool has a sensor device (8, 9), by means of which a user-generated actuating motion of at least a part of the hand-held power tool can be determined, and an actuating quantity can be generated from the determined actuating motion, in a closed-loop or open-loop control device in the hand power tool device, for the purpose of setting the drive means, characterized in that the user-generated actuating motion is a rotational motion and an axial motion of at least a part of the hand-held power tool.
Electric power supply system for a motor vehicle of the type including firstly an electric power network having a first nominal voltage electrically linking first devices comprising an electric motor/generator, an inverter/rectifier and a first electrical energy store and secondly an electrical service network having a second nominal voltage lower than said first nominal voltage and electrically linking second devices comprising a second electrical energy store, an electronic control unit controlling transfers of energy between said power network and said service network by way of a reversible DC-to-DC converter, said electronic control unit including a first electronic module supplied with power by said power network and exchanging information with said first devices, and a second electronic module supplied with power by said service network and exchanging said information with said second devices and isolated electrically from said first module, characterized in that said first electronic module is intended to be supplied with power at a first nominal voltage and is formed on a first planar substrate and said second electronic module is intended to be supplied with power at a second nominal voltage lower than said first nominal voltage and is formed on a second planar substrate isolated electrically from said first substrate, said first substrate being arranged opposite and parallel to said second substrate and separated by an intermediate layer formed of an electrically insulating material.
Rubber composition for the manufacture of tyres, based on one or more diene elastomers, on one or more reinforcing fillers and on a vulcanization system, characterized in that the said vulcanization system comprises one or more thiazole compounds of formula: where R 1 and R 2 independently represent H or a C 1 -C 25 -hydrocarbon group chosen from linear, branched or cyclic alkyl groups and aryl groups, optionally interrupted by one or more heteroatoms, it being possible for R 1 and R 2 to together form a nonaromatic ring, R 3 represents: - a linear or branched C 1 -C 25 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more cyclic C 3 -C 10 alkyl or C 6 -C 12 aryl groups, or - a cyclic C 3 -C 10 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more linear, branched or cyclic C 1 -C 25 alkyl or C 6 -C 12 aryl groups which are optionally interrupted by one or more heteroatoms. R 1 and R 2 independently represent H or a C 1 -C 25 -hydrocarbon group chosen from linear, branched or cyclic alkyl groups and aryl groups, optionally interrupted by one or more heteroatoms, it being possible for R 1 and R 2 to together form a nonaromatic ring, R 3 represents: - a linear or branched C 1 -C 25 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more cyclic C 3 -C 10 alkyl or C 6 -C 12 aryl groups, or - a cyclic C 3 -C 10 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more linear, branched or cyclic C 1 -C 25 alkyl or C 6 -C 12 aryl groups which are optionally interrupted by one or more heteroatoms. - a linear or branched C 1 -C 25 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more cyclic C 3 -C 10 alkyl or C 6 -C 12 aryl groups, or - a cyclic C 3 -C 10 alkyl group which is optionally interrupted by one or more heteroatoms and which is optionally substituted by one or more linear, branched or cyclic C 1 -C 25 alkyl or C 6 -C 12 aryl groups which are optionally interrupted by one or more heteroatoms.
A composition comprising: an isolated polypeptide having at least 92% sequence similarity to the amino acid sequence of SEQ ID NO:397, with the proviso that if the isolated polypeptide includes additional amino acids at the amino terminal, the additional amino acids include at least 8 amino acid sequence modifications compared to amino acids 1-26 of SEQ ID NO:399, wherein the isolated polypeptide is immunologically active, optionally wherein the composition further comprises a pharmaceutically acceptable carrier. an isolated polypeptide having at least 92% sequence similarity to the amino acid sequence of SEQ ID NO:397, with the proviso that if the isolated polypeptide includes additional amino acids at the amino terminal, the additional amino acids include at least 8 amino acid sequence modifications compared to amino acids 1-26 of SEQ ID NO:399, wherein the isolated polypeptide is immunologically active, optionally wherein the composition further comprises a pharmaceutically acceptable carrier.
An apparatus for handling twistlocks configured to lock a container onto a vehicle, the apparatus comprising: a robot comprising a gripper configured to grip one of the twistlocks to be mounted onto or dismounted from a corner fitting of the container; a visual sensor arranged on the robot and configured to capture a first image of the corner fitting when the vehicle is moving in a twistlock handling station; and a control unit configured to: obtain, from the visual sensor, the first image of the corner fitting; determine, based on the first image, a first position of the corner fitting at the moment when the first image is captured by the visual sensor; determine a handling position of the gripper for the one of the twistlocks, at which the gripper is to be aligned with the corner fitting, based on the first position of the corner fitting and a position correction parameter representative of a predictive displacement of the corner fitting within a predetermined response time of the robot; and send the handling position to the robot such that the gripper moves to the handling position to handle the one of the twistlocks during the moving of the vehicle. a robot comprising a gripper configured to grip one of the twistlocks to be mounted onto or dismounted from a corner fitting of the container; a visual sensor arranged on the robot and configured to capture a first image of the corner fitting when the vehicle is moving in a twistlock handling station; and a control unit configured to: obtain, from the visual sensor, the first image of the corner fitting; determine, based on the first image, a first position of the corner fitting at the moment when the first image is captured by the visual sensor; determine a handling position of the gripper for the one of the twistlocks, at which the gripper is to be aligned with the corner fitting, based on the first position of the corner fitting and a position correction parameter representative of a predictive displacement of the corner fitting within a predetermined response time of the robot; and send the handling position to the robot such that the gripper moves to the handling position to handle the one of the twistlocks during the moving of the vehicle. obtain, from the visual sensor, the first image of the corner fitting; determine, based on the first image, a first position of the corner fitting at the moment when the first image is captured by the visual sensor; determine a handling position of the gripper for the one of the twistlocks, at which the gripper is to be aligned with the corner fitting, based on the first position of the corner fitting and a position correction parameter representative of a predictive displacement of the corner fitting within a predetermined response time of the robot; and send the handling position to the robot such that the gripper moves to the handling position to handle the one of the twistlocks during the moving of the vehicle.
A method of estimating an arrival state of a radio wave, comprising (a) a non-diffracted wave estimation step of estimating an arrival state of a radio wave other than a diffracted wave out of the radio waves transmitted from a transmission source by employing a first technique of estimating a radio wave propagation state, in which a diffracted wave is not considered; (b) a diffracted wave arrival point estimation step of estimating one or a plurality of diffraction-considering reception points that is estimated to be a point, at which the diffracted wave arrives, from the arrival state of the radio wave estimated in said non-diffracted wave estimation step; (c) a diffracted wave arrival state estimation step of estimating an arrival state of the diffracted wave at the diffraction-considering reception point estimated in said diffracted wave arrival point estimation step by employing a second technique of estimating a radio wave propagation state in which the diffracted wave is considered and which is different from said first technique of estimating a radio wave propagation state, and (d) estimating an arrival state of the radio wave from the arrival state of the radio wave estimated in said non-diffracted wave estimation step and the arrival state of the radio wave estimated in said diffracted wave arrival state estimation step. (a) a non-diffracted wave estimation step of estimating an arrival state of a radio wave other than a diffracted wave out of the radio waves transmitted from a transmission source by employing a first technique of estimating a radio wave propagation state, in which a diffracted wave is not considered; (b) a diffracted wave arrival point estimation step of estimating one or a plurality of diffraction-considering reception points that is estimated to be a point, at which the diffracted wave arrives, from the arrival state of the radio wave estimated in said non-diffracted wave estimation step; (c) a diffracted wave arrival state estimation step of estimating an arrival state of the diffracted wave at the diffraction-considering reception point estimated in said diffracted wave arrival point estimation step by employing a second technique of estimating a radio wave propagation state in which the diffracted wave is considered and which is different from said first technique of estimating a radio wave propagation state, and (d) estimating an arrival state of the radio wave from the arrival state of the radio wave estimated in said non-diffracted wave estimation step and the arrival state of the radio wave estimated in said diffracted wave arrival state estimation step.