mhurhangee/ep-ind-claims huggingface dataset:
A method of excising a modified nucleotide from a polynucleotide characterized in that it comprises: (a) combining: (i) a nicking agent formed by mixing a DNA glycosylase and a single-strand cleaving enzyme, with (ii) a polynucleotide containing a modified nucleotide; and (b) excising the modified nucleotide from the polynucleotide. (a) combining: (i) a nicking agent formed by mixing a DNA glycosylase and a single-strand cleaving enzyme, with (ii) a polynucleotide containing a modified nucleotide; and (b) excising the modified nucleotide from the polynucleotide.
An subtilisin variant comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 1 or 34 and comprising an amino acid substitution X120R wherein the amino acid positions of the variant are numbered by correspondence with the amino acid sequence of SEQ ID NO: 1, and wherein said variant has protease activity, wherein said variant has improved cleaning performance when compared to a reference subtilisin comprising an amino acid sequence of SEQ ID NO: 1 or 34, wherein said variant has a BMI (blood/milk/ink on cotton), POM (pigment/oil/milk) and/or egg yolk with pigment swatch cleaning PI >1, optionally wherein cleaning performance in detergent is measured in accordance the cleaning performance in detergent assay of Example 1.
An apparatus for collecting blood in a container, comprising: a main body (21.1) including a collection cavity (21.2) adapted and configured to receive therein an end of a separable container; a sliding member guided to slide along a path within the collection cavity (21.2) from a first position to a second position and including a cover defining an aperture; a first retractable hollow needle coupled to said main body (21.1) and having a first sharp tip, wherein in the first position the first tip is extended for insertion into a blood vessel and in the second position the first tip is protected within said main body (21.1); a second hollow needle attached to said main body (21.1) and having a second sharp tip extending through the aperture in the first position into the collection cavity (21.2); and a catheter having a hollow lumen and receiving said first needle within the lumen when said first needle is in the first position; wherein said first needle is separated from said lumen in the second position, and said cover shields said second needle within the collection cavity (21.2) in the second position. a main body (21.1) including a collection cavity (21.2) adapted and configured to receive therein an end of a separable container; a sliding member guided to slide along a path within the collection cavity (21.2) from a first position to a second position and including a cover defining an aperture; a first retractable hollow needle coupled to said main body (21.1) and having a first sharp tip, wherein in the first position the first tip is extended for insertion into a blood vessel and in the second position the first tip is protected within said main body (21.1); a second hollow needle attached to said main body (21.1) and having a second sharp tip extending through the aperture in the first position into the collection cavity (21.2); and a catheter having a hollow lumen and receiving said first needle within the lumen when said first needle is in the first position; wherein said first needle is separated from said lumen in the second position, and said cover shields said second needle within the collection cavity (21.2) in the second position.
A tool for thermoforming a container having a base and an upstanding sidewall or walls, the tool including a mould having a profile shaped to form the exterior shape of the container, a plug adapted to be inserted in the mould to define the interior of the container, the plug having a lower face adapted to define the profile of the base of the container, wherein the profile of the lower face of the plug has a plurality of grooves adapted to form a plurality of ribs upstanding in the interior of the base of the container, wherein the lower face of the plug has a peripheral groove or rib extending around the periphery of the base adjacent the sidewall of the container, the peripheral groove or rib mating with a corresponding peripheral rib or groove, as the case may be, on or in the mould to securely clamp the material of the container between the mould and the plug so that the wall of the container and the base of the container can be subjected to different pressures.
An unbalance detection method for a front-loading washing machine, comprising the following steps of: A. during an accelerative operation of a drum according to a constant acceleration: - detecting a torque of the drum and acquiring a torque average value in a period of per rotation that the drum completes; - once the drum completes one rotation at the beginning of the accelerative operation, setting the acquired torque average value of that rotation as a minimum torque average value; - when the drum completes another one rotation and another torque average value is acquired, comparing the another acquired torque average value with the minimum torque average value, and updating the minimum torque average value according to the comparison; and B. judging whether a difference value between the torque average value and the minimum torque average value is greater than a preset unbalance threshold value, and if the difference value is greater than the preset unbalance threshold value, determining that dynamic unbalance appears in the drum, otherwise determining that no dynamic unbalance appears in the drum. A. during an accelerative operation of a drum according to a constant acceleration: - detecting a torque of the drum and acquiring a torque average value in a period of per rotation that the drum completes; - once the drum completes one rotation at the beginning of the accelerative operation, setting the acquired torque average value of that rotation as a minimum torque average value; - when the drum completes another one rotation and another torque average value is acquired, comparing the another acquired torque average value with the minimum torque average value, and updating the minimum torque average value according to the comparison; and B. judging whether a difference value between the torque average value and the minimum torque average value is greater than a preset unbalance threshold value, and - detecting a torque of the drum and acquiring a torque average value in a period of per rotation that the drum completes; - once the drum completes one rotation at the beginning of the accelerative operation, setting the acquired torque average value of that rotation as a minimum torque average value; - when the drum completes another one rotation and another torque average value is acquired, comparing the another acquired torque average value with the minimum torque average value, and updating the minimum torque average value according to the comparison; and B. judging whether a difference value between the torque average value and the minimum torque average value is greater than a preset unbalance threshold value, and
An adjustable foot for an electric household appliance, in particular a rear foot for a washing machine, comprising a body integrally fastenable to a casing of the electric household appliance, a stem carried by the body so as to vertically slide, floor resting means associated with a lower end of the stem, first screw means operatively associated with the stem and provided with anti-rotation means cooperating with the body, a toothed wheel carried by the body so as to be coaxial to the stem and idle about a substantially vertical symmetry axis of the latter, second screw means operatively associated with the toothed wheel and cooperating with the first screw means for vertically translating the stem in response to a rotation of the toothed wheel, and control means for the toothed wheel; characterized in that the toothed wheel is axially mounted with a clearance between opposite first and second abutting means of the body, which is provided with elastic axial biasing means cooperating with the toothed wheel and arranged at the first abutting means, the latter facing towards an end length of the first screw means having a thread height gradually decreasing towards the elastic axial biasing means.
A process for the production of a copolymer, preferably a poly(acrylic acid-co-acrylate ester) or a poly(methacrylic acid-co-methacrylate ester), or a terpolymer, preferably a poly(acrylic acid-co-acrylate ester -co-acrylate ester) or a poly(methacrylic acid-co-methacrylate ester -co-methacrylate ester) comprising: (a) esterifying a polyacrylic or polymethacrylic acid with one or two alcohols in the presence of a least amount of an acid as a catalyst; and (b) extracting water produced in (a) through a membrane. (a) esterifying a polyacrylic or polymethacrylic acid with one or two alcohols in the presence of a least amount of an acid as a catalyst; and (b) extracting water produced in (a) through a membrane.
A biopsy device comprising an outer sleeve, a hollow main shaft, the main shaft having a distal end portion, wherein a sideward facing notch is formed in the main shaft in the distal end portion of the main shaft, wherein the main shaft is accommodated within the outer sleeve, wherein the outer sleeve is movable relative to the main shaft between a first position in which the notch is not covered by the outer sleeve, and a second position in which the notch is covered by the outer sleeve, a tube shaft movably accommodated within the hollow main shaft, and characterised by: a biopsy tube for receiving tissue to be resected, wherein a proximal end of the biopsy tube is releasably attachable to a distal end of the tube shaft so that the biopsy tube is movable together with the tube shaft within the hollow main shaft between a proximal position in which the biopsy tube is not located in the notch, and a distal position in which the biopsy tube is located in the notch. a biopsy tube for receiving tissue to be resected, wherein a proximal end of the biopsy tube is releasably attachable to a distal end of the tube shaft so that the biopsy tube is movable together with the tube shaft within the hollow main shaft between a proximal position in which the biopsy tube is not located in the notch, and a distal position in which the biopsy tube is located in the notch.
A computer-implemented method of determining blood pressure of a subject, the method comprising: receiving an envelope data set for the subject, the envelope data set comprising measurements of blood flow in a body part of the subject for respective different degrees of restriction applied to the body part; using a set of probability density functions, PDFs, to determine respective likelihoods for obtaining the measurements in the envelope data set for different pairs of values of the systolic blood pressure and diastolic blood pressure; and determining the systolic blood pressure and the diastolic blood pressure for the subject as the pair of values of the systolic blood pressure and diastolic blood pressure that provides the highest likelihood for the envelope data set. receiving an envelope data set for the subject, the envelope data set comprising measurements of blood flow in a body part of the subject for respective different degrees of restriction applied to the body part; using a set of probability density functions, PDFs, to determine respective likelihoods for obtaining the measurements in the envelope data set for different pairs of values of the systolic blood pressure and diastolic blood pressure; and determining the systolic blood pressure and the diastolic blood pressure for the subject as the pair of values of the systolic blood pressure and diastolic blood pressure that provides the highest likelihood for the envelope data set.
Nanoparticles of disintegratable mesoporous organometaloxide material having a particle diameter from 1 to 500 nm and comprising a mesoporous three-dimensional Si-, Ti- or Zr-based metaloxide framework of metal-oxygen bonds, wherein at least a subset of metal atoms in the material's framework are connected to at least another metal atom in the framework through a linker having one of the following structures: *-R 1 -L-R 2 -*, wherein: each occurrence of * denotes a point of attachment to a metal atom in the material's framework; L represents a responsively cleavable covalent bond selected from disulfide, and R 1 and R 2 independently represent an optionally substituted Cl-20alkylenyl moiety, an optionally substituted Cl-20heteroalkylenyl moiety, an optionally substituted ethylenyl moiety, -C≡C- or an optionally substituted phenyl moiety, wherein the C1-20alkylenyl, C1-20heteroalkylenyl or ethylenyl moiety may bear one or more substituents selected from halogen or -OR where R may represent H or C1-6alkyl, and the phenyl moiety may bear one or more substituents independently selected from halogen, Cl-6alkyl, -NO 2, -CN, isocyano, -OR p, -N(R p) 2 wherein each occurrence of R p independently represents H or C1-6alkyl, wherein the disintegratable mesoporous organometaloxide material comprises in its pores or at its surface at least one marker and/or cosmetically or pharmaceutically active principle. each occurrence of * denotes a point of attachment to a metal atom in the material's framework; L represents a responsively cleavable covalent bond selected from disulfide, and R 1 and R 2 independently represent an optionally substituted Cl-20alkylenyl moiety, an optionally substituted Cl-20heteroalkylenyl moiety, an optionally substituted ethylenyl moiety, -C≡C- or an optionally substituted phenyl moiety, wherein the C1-20alkylenyl, C1-20heteroalkylenyl or ethylenyl moiety may bear one or more substituents selected from halogen or -OR where R may represent H or C1-6alkyl, and the phenyl moiety may bear one or more substituents independently selected from halogen, Cl-6alkyl, -NO 2, -CN, isocyano, -OR p, -N(R p) 2 wherein each occurrence of R p independently represents H or C1-6alkyl, wherein the disintegratable mesoporous organometaloxide material comprises in its pores or at its surface at least one marker and/or cosmetically or pharmaceutically active principle.
A liquid ink writing instrument comprising: a pen body for containing ink and constituting the principal part of the writing instrument; a writing element mounted on the head of the pen body; an ink absorber mounted on the rear end of the writing element; an ink feeder mounted in the pen body and penetrating through said ink absorber, wherein the front end of said ink feeder is contacted with the writing element, and the rear end of said ink feeder is communicated with an ink cartridge formed by the inner cavity of the pen body; wherein, an air-liquid balancer is set in the pen body along the axial direction, the air-liquid balancer is installed between the ink feeder and the pen body; there is one or more air-liquid exchange grooves penetrating the outer circumferential surface of the air-liquid balancer and having a capillary attraction effect on the ink; there is an overflow groove on a radial surface of the air-liquid balancer, one end of which is in contact with the ink feeder, and the other end of which is communicated with the air-liquid exchange groove; a transition fit or an interference fit is adopted between the outer circumferential surface of the ink feeder and the inner wall of the air-liquid balancer characterized in that the ink feeder is a fiber ink feeder and there is provided a plurality of air-liquid balancers partitioning the inner cavity of the pen body into a plurality of ink cartridges, and the volume relationship between two consecutive ink cartridges (6, 7, 8) partitioned by the independent air-liquid balancers is: along the writing element end to the farthest end, the volume of ink cartridge at the far end is greater than that of ink cartridge at the near end.
A method for operating a heat pump system, the heat pump system comprising: a compression device, a heat rejecting heat exchanger, an expansion device and a heat absorbing heat exchanger; wherein the expansion device provides a controllable degree of expansion; the method comprising: determining a temperature indicative of frosting conditions on an exterior surface of the heat absorbing heat exchanger; operating the heat pump system in a first mode if the temperature indicative of frosting conditions is above a threshold value; and operating the heat pump system in a second mode if the temperature indicative of frosting conditions is within a range of temperatures that is below the threshold value; wherein in the second mode the heat pump system is arranged to adjust the degree of expansion at the expansion device to increase the superheat at the outlet of the heat absorbing heat exchanger compared to the superheat when operating in the first mode to thereby increase an external temperature of the heat absorbing heat exchanger; characterised in that the range of temperatures below the threshold value is a range having a lower bound, wherein, when the temperature indicative of frosting conditions is below the lower bound, the heat pump system is switched back to the first mode of operation. determining a temperature indicative of frosting conditions on an exterior surface of the heat absorbing heat exchanger; operating the heat pump system in a first mode if the temperature indicative of frosting conditions is above a threshold value; and operating the heat pump system in a second mode if the temperature indicative of frosting conditions is within a range of temperatures that is below the threshold value; wherein in the second mode the heat pump system is arranged to adjust the degree of expansion at the expansion device to increase the superheat at the outlet of the heat absorbing heat exchanger compared to the superheat when operating in the first mode to thereby increase an external temperature of the heat absorbing heat exchanger; characterised in that the range of temperatures below the threshold value is a range having a lower bound, wherein, when the temperature indicative of frosting conditions is below the lower bound, the heat pump system is switched back to the first mode of operation.
A connector converter, comprising a shell, a digital signal board and a connecting wire, wherein the digital signal board is integrated with a digital circuit, the digital signal board is provided in the shell, an inner end of the connecting wire is electrically connected to the digital signal board, an outer end of the connecting wire extends out to the shell and is provided with an input interface, the digital signal board is provided with a plurality of output interfaces, and the shell is provided with an outer pocket positioned corresponding to the output interface such that the output interface is exposed; characterized in that the connector converter comprises further a power source board, the power source board is integrated with a power source circuit, the power source board is also provided in the shell and electrically connected to digital signal board, and the digital signal board and the power source board are provided at a distance from each other so that signal interference between the digital circuit and power source circuit can be effectively avoided during operation of the connector converter. characterized in that the connector converter comprises further a power source board, the power source board is integrated with a power source circuit, the power source board is also provided in the shell and electrically connected to digital signal board, and the digital signal board and the power source board are provided at a distance from each other so that signal interference between the digital circuit and power source circuit can be effectively avoided during operation of the connector converter.
A dry water treatment membrane comprising: a porous support; a polyamide active layer provided on the porous support; and a coating layer including a glycerin compound and polyvinyl alcohol provided on the polyamide active layer, wherein moisture content is from 2% to 4% wherein the moisture content is determined as set out in the description, wherein the glycerin compound is a compound represented by the following Chemical Formula 1: wherein, in Chemical Formula 1, n is an integer of 0 to 12, wherein the coating layer is formed by coating only top of the polyamide active layer with a composition including a glycerin compound and polyvinyl alcohol, wherein the glycerin compound content is from 2% by weight to 4% by weight with respect to the content of the whole composition, wherein polyvinyl alcohol content is from 1% by weight to 5% by weight with respect to the content of the whole composition, and wherein the composition further includes alcohol in 0.1% by weight to 20% by weight based on the content of the whole composition wherein the alcohol used as the solvent is one or more selected from the group consisting of methanol, ethanol, propanol and isopropanol. a porous support; a polyamide active layer provided on the porous support; and a coating layer including a glycerin compound and polyvinyl alcohol provided on the polyamide active layer, wherein moisture content is from 2% to 4% wherein the moisture content is determined as set out in the description, wherein the glycerin compound is a compound represented by the following Chemical Formula 1: wherein, in Chemical Formula 1, n is an integer of 0 to 12, wherein the coating layer is formed by coating only top of the polyamide active layer with a composition including a glycerin compound and polyvinyl alcohol, wherein the glycerin compound content is from 2% by weight to 4% by weight with respect to the content of the whole composition, wherein polyvinyl alcohol content is from 1% by weight to 5% by weight with respect to the content of the whole composition, and wherein the composition further includes alcohol in 0.1% by weight to 20% by weight based on the content of the whole composition wherein the alcohol used as the solvent is one or more selected from the group consisting of methanol, ethanol, propanol and isopropanol.
A nanographitic composite for use as an anode in a lithium ion battery, comprising: a plurality of composite particles comprising, each composite particle comprising: a particle core comprising an electroactive material; a coating layer comprising an inner layer of graphene nanoplatelets that is bound by covalent or interdiffusion bonding to the electroactive particle and an outer layer of graphene nanoplatelets disposed over the inner layer of graphene that interact loosely with the inner layer of graphene nanoplatelets, wherein graphene nanoplatelets in the outer layer comprise graphene nanoplatelets having a longest lateral dimension that is less than a longest lateral dimension in the electroactive particle. a particle core comprising an electroactive material; a coating layer comprising an inner layer of graphene nanoplatelets that is bound by covalent or interdiffusion bonding to the electroactive particle and an outer layer of graphene nanoplatelets disposed over the inner layer of graphene that interact loosely with the inner layer of graphene nanoplatelets, wherein graphene nanoplatelets in the outer layer comprise graphene nanoplatelets having a longest lateral dimension that is less than a longest lateral dimension in the electroactive particle.