mhurhangee/ep-ind-claims huggingface dataset:
A Dry Powder Inhaler, DPI, arrangement comprising a DPI arranged in fluid communication with a spacer device, the spacer device comprising: a body in the form of a generally V-shaped mounting formed by opposing inlet and outlet passages intersecting at an angle of between 30 and 170 degrees along their respective longitudinal axes; and a demountable, flexible bag attached below the body, the bag and body together defining a chamber, such that the inlet and outlet passages are in fluid flow communication with an interior of the chamber; wherein the inlet is configured for operative connection to the DPI containing a drug to be inhaled; wherein the outlet is configured to be operatively received by a user's mouth; and characterized in that the V-shaped mounting includes a V-shaped interior surface, and has a lower perimeter formed by the merging of the inferior and lateral aspects of the merging inlet and outlet, said perimeter being generally oval in shape; wherein the DPI includes expulsion means for expelling a powdered drug from the DPI into the spacer device, said drug encapsulated in the form of a capsule, caplet, or gel covering, said expulsion means including piercing means for piercing said capsule, caplet or gel covering to liberate the powder prior to expulsion from the DPI; and wherein the flexible bag serves as reservoir to allow for the formation of a vapour or particle cloud of the drug to be inhaled therewithin following activation of the DPI, the flexible bag being configured to be at least partially inflatable and at least partially deflatable commensurate with breathing and/or rebreathing of said user. a body in the form of a generally V-shaped mounting formed by opposing inlet and outlet passages intersecting at an angle of between 30 and 170 degrees along their respective longitudinal axes; and a demountable, flexible bag attached below the body, the bag and body together defining a chamber, such that the inlet and outlet passages are in fluid flow communication with an interior of the chamber; wherein the inlet is configured for operative connection to the DPI containing a drug to be inhaled; wherein the outlet is configured to be operatively received by a user's mouth; and characterized in that the V-shaped mounting includes a V-shaped interior surface, and has a lower perimeter formed by the merging of the inferior and lateral aspects of the merging inlet and outlet, said perimeter being generally oval in shape; wherein the DPI includes expulsion means for expelling a powdered drug from the DPI into the spacer device, said drug encapsulated in the form of a capsule, caplet, or gel covering, said expulsion means including piercing means for piercing said capsule, caplet or gel covering to liberate the powder prior to expulsion from the DPI; and wherein the flexible bag serves as reservoir to allow for the formation of a vapour or particle cloud of the drug to be inhaled therewithin following activation of the DPI, the flexible bag being configured to be at least partially inflatable and at least partially deflatable commensurate with breathing and/or rebreathing of said user.
A program which, when running on a computer, causes the computer to perform a method for positioning a patient's body part including a target to be depicted by means of an x-ray imaging device relative to a trajectory of a radiation beam generated by the x-ray imaging device and directed towards the target, the method comprising the following steps: - receiving, at the processor, geometry data describing the geometry of an elongated instrument introduced into the patient's body part, located in the field of view of the x-ray imaging device, and having a shape alteration in one spatial direction; - receiving, at the processor, tracking data describing the spatial orientation of the elongated instrument within the field of view of the x-ray imaging device; - determining, with the processor, position data incorporating the geometry data and the tracking data, describing whether the orientation of the at least one elongated instrument with respect to the radiation beam trajectory through the target is desirable; - determining, with the processor, repositioning data describing a desired orientation of the elongated instrument with respect to the radiation beam trajectory through the target for which the spatial direction of the shape alteration of the elongated instrument is perpendicular to the radiation beam trajectory; - outputting, from the processor, the repositioning data allowing for repositioning of the patient's body part and the x-ray imaging device with respect to each other so as to have the elongated instrument oriented with the desired orientation with respect to the radiation beam trajectory. - receiving, at the processor, geometry data describing the geometry of an elongated instrument introduced into the patient's body part, located in the field of view of the x-ray imaging device, and having a shape alteration in one spatial direction; - receiving, at the processor, tracking data describing the spatial orientation of the elongated instrument within the field of view of the x-ray imaging device; - determining, with the processor, position data incorporating the geometry data and the tracking data, describing whether the orientation of the at least one elongated instrument with respect to the radiation beam trajectory through the target is desirable; - determining, with the processor, repositioning data describing a desired orientation of the elongated instrument with respect to the radiation beam trajectory through the target for which the spatial direction of the shape alteration of the elongated instrument is perpendicular to the radiation beam trajectory; - outputting, from the processor, the repositioning data allowing for repositioning of the patient's body part and the x-ray imaging device with respect to each other so as to have the elongated instrument oriented with the desired orientation with respect to the radiation beam trajectory.
A valve arrangement comprising a valve housing, a valve inlet, a valve outlet, a flow valve element and a flow valve seat, the flow valve seat being arranged in a flow path connecting the valve inlet to the valve outlet and the flow valve element cooperating with the flow valve seat, the valve arrangement comprising a pressure valve element for determining a predetermined flow at a predetermined opening position of the flow valve element, wherein the valve arrangement comprises an insert, the pressure valve element being mounted to the insert, characterized in that the insert comprises one or more elongated grooves, the grooves reducing velocity of a fluid flow through the insert.
A tufting machine, comprising: at least one needle bar having a series of needles mounted therealong; backing feed rolls feeding a backing material along a path of travel through the tufting machine; a yarn feed mechanism feeding a series of yarns to the needles; gauge parts reciprocated into engagement with at least some of the needles as the needles are engaged with the backing material to form tufts of yarns in the backing material; a shift mechanism coupled to the at least one needle bar and operable for shifting the needles in a direction substantially transverse to the path of travel of the backing material, the shift mechanism comprising: a rack linked to the at least one needle bar and having a series of spaced teeth; characterized by further comprising: a pair of roller pinions, each having a series of rollers, and each being engaged by multiple teeth of the rack to provide multiple points of contact between the rack and the pinions; and a pair of motors, each engaging one of the pair of roller pinions, whereby as the pinion is rotated, the rack is moved linearly so as to cause the transverse shifting movement of the needles across the backing material. at least one needle bar having a series of needles mounted therealong; backing feed rolls feeding a backing material along a path of travel through the tufting machine; a yarn feed mechanism feeding a series of yarns to the needles; gauge parts reciprocated into engagement with at least some of the needles as the needles are engaged with the backing material to form tufts of yarns in the backing material; a shift mechanism coupled to the at least one needle bar and operable for shifting the needles in a direction substantially transverse to the path of travel of the backing material, the shift mechanism comprising: a rack linked to the at least one needle bar and having a series of spaced teeth; characterized by further comprising: a pair of roller pinions, each having a series of rollers, and each being engaged by multiple teeth of the rack to provide multiple points of contact between the rack and the pinions; and a pair of motors, each engaging one of the pair of roller pinions, whereby as the pinion is rotated, the rack is moved linearly so as to cause the transverse shifting movement of the needles across the backing material. a pair of roller pinions, each having a series of rollers, and each being engaged by multiple teeth of the rack to provide multiple points of contact between the rack and the pinions; and a pair of motors, each engaging one of the pair of roller pinions, whereby as the pinion is rotated, the rack is moved linearly so as to cause the transverse shifting movement of the needles across the backing material.
A park lock for a motor vehicle, wherein the park lock has: - a locking pawl, which is pivotably arranged about an axis of rotation (a) and has a pawl tooth, which is designed for positive engagement in a park lock gear, wherein the locking pawl has a pawl recess, into which an engaging means engages, characterised in that the locking pawl is actuated by a roller (13, 14, 15), wherein the locking pawl is prestressed by a prestressing means against the roller (13, 14, 15). - a locking pawl, which is pivotably arranged about an axis of rotation (a) and has a pawl tooth, which is designed for positive engagement in a park lock gear, wherein
Broadcast radio receiver having - a broadcast radio reception portion (2, 22), - a decoder for data received using a broadcast radio frequency that contain an identifier, - at least one memory element (8, 28), - a multiplicity of stored identifiers that are stored in the at least one memory element (8, 28), - graphical elements that are stored in the at least one memory element (8, 28), wherein at least some of the stored identifiers each have one of the graphical elements associated with them, - a graphics-compatible display (7, 27), - means for extracting the identifier from the received data and for comparing the extracted identifier with the multiplicity of identifiers stored in the memory element (8, 28) and for selecting the graphical element associated with a stored identifier that matches the extracted identifier, - means for presenting the selected graphical element on the graphics-compatible display (7, 27). - a broadcast radio reception portion (2, 22), - a decoder for data received using a broadcast radio frequency that contain an identifier, - at least one memory element (8, 28), - a multiplicity of stored identifiers that are stored in the at least one memory element (8, 28), - graphical elements that are stored in the at least one memory element (8, 28), wherein at least some of the stored identifiers each have one of the graphical elements associated with them, - a graphics-compatible display (7, 27), - means for extracting the identifier from the received data and for comparing the extracted identifier with the multiplicity of identifiers stored in the memory element (8, 28) and for selecting the graphical element associated with a stored identifier that matches the extracted identifier, - means for presenting the selected graphical element on the graphics-compatible display (7, 27).
A humanized antibody that specifically binds αvβ8 integrin, wherein the antibody inhibits release of active, mature TGFβ peptide, but does not significantly inhibit adhesion of latent TGFβ to αvβ8 integrin on a αvβ8-expressing cell, and wherein the antibody has a heavy chain variable region of SEQ ID NO:8 and a light chain variable region of SEQ ID NO:9.
Device for the production of drops from a flowable material, comprising - a reservoir for the flowable material, and - a distribution chamber having an inlet opening for supplying the flowable material and having a plurality of outlet openings for discharge of the flowable material in the form of individual material discharge strands, - wherein each outlet opening is formed by an outlet connection piece and - wherein, internally of the outlet connection piece, an outlet channel is arranged which terminates in the outlet opening, characterized in - that the outlet connection piece for fluid connection of the outlet channel to the distribution chamber is further provided with a restrictor bore which, starting from the distribution chamber, opens into the outlet channel. - a reservoir for the flowable material, and - a distribution chamber having an inlet opening for supplying the flowable material and having a plurality of outlet openings for discharge of the flowable material in the form of individual material discharge strands, - wherein each outlet opening is formed by an outlet connection piece and - wherein, internally of the outlet connection piece, an outlet channel is arranged which terminates in the outlet opening, characterized in - that the outlet connection piece for fluid connection of the outlet channel to the distribution chamber is further provided with a restrictor bore which, starting from the distribution chamber, opens into the outlet channel.
A radio-frequency apparatus, comprising: an integrated circuit (214, 407, 610, 710, 801), comprising: receiver analog circuitry (824, 409, 833, 418), the receiver analog circuitry configured to receive radio-frequency signals and to provide a first digital signal; receiver digital circuitry (212, 426, 851), the receiver digital circuitry configured to receive the first digital signal and to provide a second digital signal; a digital-to-analog converter, the digital-to-analog converter configured to convert the second digital signal into a first analog signal; and being characterised by a signal selector, the signal selector configured to receive the second digital signal and the first analog signal, the signal selector further configured to selectively provide one of the second digital signal and the first analog signal as an output signal of the integrated circuit (214, 407, 610, 710, 801). an integrated circuit (214, 407, 610, 710, 801), comprising: receiver analog circuitry (824, 409, 833, 418), the receiver analog circuitry configured to receive radio-frequency signals and to provide a first digital signal; receiver digital circuitry (212, 426, 851), the receiver digital circuitry configured to receive the first digital signal and to provide a second digital signal; a digital-to-analog converter, the digital-to-analog converter configured to convert the second digital signal into a first analog signal; and receiver analog circuitry (824, 409, 833, 418), the receiver analog circuitry configured to receive radio-frequency signals and to provide a first digital signal; receiver digital circuitry (212, 426, 851), the receiver digital circuitry configured to receive the first digital signal and to provide a second digital signal; a digital-to-analog converter, the digital-to-analog converter configured to convert the second digital signal into a first analog signal; and being characterised by a signal selector, the signal selector configured to receive the second digital signal and the first analog signal, the signal selector further configured to selectively provide one of the second digital signal and the first analog signal as an output signal of the integrated circuit (214, 407, 610, 710, 801). a signal selector, the signal selector configured to receive the second digital signal and the first analog signal, the signal selector further configured to selectively provide one of the second digital signal and the first analog signal as an output signal of the integrated circuit (214, 407, 610, 710, 801).
A pouch-shaped secondary battery comprising: an electrode assembly; and a pouch-shaped case configured to receive the electrode assembly, wherein the pouch-shaped case has therein a gas pocket configured such that at least a portion of the gas pocket is maintained in a folded state and such that, when gas is generated in the pouch-shaped case, the gas pocket is unfolded to form a space configured to collect the gas, the pouch-shaped case is configured to have a quadrangular planar structure in which a perimetric surface of this quadrangular plane comprises a single surface that is folded and three surfaces (24, 25) that are attached by sealing, the gas pocket is formed at the single surface that is folded, the pouch-shaped case comprises a case main body, in which the electrode assembly is mounted, and the gas pocket formed at one side of the case main body, and the gas pocket is configured to have a structure in which the gas pocket is bent from the case main body and is then in tight contact with the case main body. an electrode assembly; and a pouch-shaped case configured to receive the electrode assembly, wherein the pouch-shaped case has therein a gas pocket configured such that at least a portion of the gas pocket is maintained in a folded state and such that, when gas is generated in the pouch-shaped case, the gas pocket is unfolded to form a space configured to collect the gas, the pouch-shaped case is configured to have a quadrangular planar structure in which a perimetric surface of this quadrangular plane comprises a single surface that is folded and three surfaces (24, 25) that are attached by sealing, the gas pocket is formed at the single surface that is folded, the pouch-shaped case comprises a case main body, in which the electrode assembly is mounted, and the gas pocket formed at one side of the case main body, and the gas pocket is configured to have a structure in which the gas pocket is bent from the case main body and is then in tight contact with the case main body.
A host-expression system comprising a host cell that has been genetically engineered to express a first vector encoding a transcript comprising a first nucleic acid sequence encoding a first immunoglobulin heavy chain or immunoglobulin light chain, wherein transcription of said first nucleic acid sequence is induced simultaneously with transcription of a second nucleic acid sequence encoding a first subunit of a selectable marker, and a second vector encoding a transcript comprising a third nucleic acid sequence encoding a second immunoglobulin heavy chain or immunoglobulin light chain that is capable of associating with the first immunoglobulin heavy chain or immunoglobulin light chain to form a heteromeric complex, wherein transcription of said third nucleic acid sequence is induced simultaneously with transcription of a fourth nucleic acid sequence encoding a second subunit of a selectable marker, and wherein said first and second selectable marker subunits associate to provide a selectable activity, wherein an internal ribosomal entry site occurs between the first nucleic acid sequence and the second nucleic acid sequence, wherein an internal ribosomal entry site occurs between the third nucleic acid sequence and the fourth nucleic acid sequence, and the heteromeric complex is an antibody.
A non-therapeutic method of treatment comprising: placing a piezoelectric transducer at a first location above the skin; transmitting focused acoustic waves from the piezoelectric transducer into the skin to create a point of treatment wherein the focused acoustic waves have a 6 dB focal zone with a focal diameter of 1.5 mm or less and a depth of focus of 3 mm or less, wherein a piezoelectric element of the piezoelectric transducer is operated at a third, or higher, harmonic resonance frequency; and moving the piezoelectric transducer along the surface of the skin to a second location 5 mm or less from the first location and repeating the transmitting step. placing a piezoelectric transducer at a first location above the skin; transmitting focused acoustic waves from the piezoelectric transducer into the skin to create a point of treatment wherein the focused acoustic waves have a 6 dB focal zone with a focal diameter of 1.5 mm or less and a depth of focus of 3 mm or less, wherein a piezoelectric element of the piezoelectric transducer is operated at a third, or higher, harmonic resonance frequency; and moving the piezoelectric transducer along the surface of the skin to a second location 5 mm or less from the first location and repeating the transmitting step.
A process for obtaining aluminum methyl methylphosphonate comprising reacting aluminum hydroxide with dimethyl methylphosphonate in the presence of an efficient catalyst, wherein the catalyst is selected from the group consisting of a phase transfer catalyst, a thermally stable tertiary amine having a boiling point higher than 140°C, a thermally stable phosphine having a boiling point higher than 140°C and combinations thereof.
A modified conjugated diene-based polymer comprising a first polymer chain and a second polymer chain, comprising a repeating unit derived from a conjugated diene-based monomer and a derived unit from a nitrogen-containing modification initiator in each, wherein the first polymer chain comprises a derived unit from an aminoalkoxysilane-based modifier in at least one terminal, the second polymer chain comprises a derived unit from an aminoepoxy-based modifier in at least one terminal, and the aminoalkoxysilane-based modifier comprises 6 or more alkoxy groups in a molecule. wherein the first polymer chain comprises a derived unit from an aminoalkoxysilane-based modifier in at least one terminal, the second polymer chain comprises a derived unit from an aminoepoxy-based modifier in at least one terminal, and the aminoalkoxysilane-based modifier comprises 6 or more alkoxy groups in a molecule.
A radiation-curable ink composition comprising: a polymerizable compound as Component A; a photopolymerization initiator as Component B; and two or more types of surfactants as Component C, wherein Component A comprises a urethane oligomer having a polymerizable group and a partial structure represented by Formula a-1 below, Component C comprises at least a surfactant that has a polymerizable group and a surfactant that does not have a polymerizable group, and the mass ratio of a content C 1 of the surfactant that has a polymerizable group and a content C 2 of the surfactant that does not have a polymerizable group is C 1:C 2 =35:1 to 1:10, wherein the Xs independently denote a urethane bond (-NH-CO-), an ester bond (-CO-O-), an ethyleneoxy group, a propyleneoxy group, or an alkylene group, and * denotes the position of bonding. a polymerizable compound as Component A; a photopolymerization initiator as Component B; and two or more types of surfactants as Component C, wherein Component A comprises a urethane oligomer having a polymerizable group and a partial structure represented by Formula a-1 below, Component C comprises at least a surfactant that has a polymerizable group and a surfactant that does not have a polymerizable group, and the mass ratio of a content C 1 of the surfactant that has a polymerizable group and a content C 2 of the surfactant that does not have a polymerizable group is C 1:C 2 =35:1 to 1:10, wherein the Xs independently denote a urethane bond (-NH-CO-), an ester bond (-CO-O-), an ethyleneoxy group, a propyleneoxy group, or an alkylene group, and * denotes the position of bonding.