mhurhangee/ep-ind-claims huggingface dataset:
An oligonucleotide comprising one or more nucleoside analogues each independently of the general formula II: wherein R 1 and R 4 each independently is selected from H, halogen, -CN, -SCN, -NO 2, -O-hydrocarbyl, -S-hydrocarbyl, -CO-H, -CO-hydrocarbyl, -NR 8 R 9, heteroaryl, or hydrocarbyl optionally substituted by one or more groups each independently is halogen, -CN, -SCN, or -NO 2, wherein R 8 and R 9 are each independently H or hydrocarbyl; or R 8 and R 9 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen or sulfur; R 2 is H or absent; R 3 is O or -NR 10 R 10', wherein wherein R 10 and R 10' are each independently H, hydrocarbyl, or -CO-hydrocarbyl; R 5 is halogen, -O -, or -OR 11; R 6 is -O -, or -OR 11; R 7 is -OR 11, a monophosphate moiety, or a phosphate linking moiety; R 11 each independently is (C 1 -C 8)alkyl, (C 1 -C 8)alkylene-OR 12, (C 1 -C 8)alkylene-SR 12, or (C 1 -C 8)alkylene-NR 12 R 13, wherein R 12 and R 13 each independently is H or (C 1 -C 8)alkyl; and the dotted line represents a potential double bond between the carbon atom at position 4 and either the nitrogen atom at position 3 or the radical R 3, provided that, when R 2 is H, there is a double bond between the carbon atom at position 4 and R 3, and when R 2 is absent, there is a double bond between the carbon atom at position 4 and the nitrogen atom at position 3. wherein R 1 and R 4 each independently is selected from H, halogen, -CN, -SCN, -NO 2, -O-hydrocarbyl, -S-hydrocarbyl, -CO-H, -CO-hydrocarbyl, -NR 8 R 9, heteroaryl, or hydrocarbyl optionally substituted by one or more groups each independently is halogen, -CN, -SCN, or -NO 2, wherein R 8 and R 9 are each independently H or hydrocarbyl; or R 8 and R 9 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen or sulfur; R 2 is H or absent; R 3 is O or -NR 10 R 10', wherein wherein R 10 and R 10' are each independently H, hydrocarbyl, or -CO-hydrocarbyl; R 5 is halogen, -O -, or -OR 11; R 6 is -O -, or -OR 11; R 7 is -OR 11, a monophosphate moiety, or a phosphate linking moiety; R 11 each independently is (C 1 -C 8)alkyl, (C 1 -C 8)alkylene-OR 12, (C 1 -C 8)alkylene-SR 12, or (C 1 -C 8)alkylene-NR 12 R 13, wherein R 12 and R 13 each independently is H or (C 1 -C 8)alkyl; and the dotted line represents a potential double bond between the carbon atom at position 4 and either the nitrogen atom at position 3 or the radical R 3, provided that, when R 2 is H, there is a double bond between the carbon atom at position 4 and R 3, and when R 2 is absent, there is a double bond between the carbon atom at position 4 and the nitrogen atom at position 3.
Closure (10, 20) with two profiled strips (11, 12; 21, 22) for an at least partially flexible container for environment-proof connection of a first container to a second container and for conducting a flow in an environment-proof way through the closure (10, 20) from the first container into the second container in an opened docking position, wherein the second container facing the first container has an identical closure (10, 20) which, in the opened docking position, is in engagement with the closure of the first container and together with the closure (10, 20) of the first container defines a throughflow channel for flow in the throughflow direction, wherein the profiled strips (11, 12; 21, 22), when arranged in relation to one another close the respective container (1, 2), and wherein, in the docked position of the closures (10, 20), a channel-inwards directed, projecting closure element (14, 24) engages a channel-outwards directed closure element (13, 23) of the complementary closure (10, 20), joining the closures (10, 20) together, characterised in that, in the separated state of the closures (10, 20), a channel-inwards directed, projecting and pivotable closure element (14, 24) is in engagement with a channel-outwards directed closure element (13, 23) of the same closure (10, 20) and thus closes the respective closure (10, 20).
Method for monitoring an ignition system of an aircraft turbine engine, the ignition system including at least one combustion chamber, at least one spark plug in the at least one combustion chamber, an ignition exciter box to excite the at least one spark plug, the turbine engine including at least one accelerometer and at least one acoustic sensor, the method being characterised in that it includes steps of: - acquiring (E2, E3, E6, E7) accelerometric and acoustic data representative of breakdown noises of the at least one spark plug, on the basis of signals produced by the at least one accelerometer and the at least one acoustic sensor, - detecting (E4, E8) times of breakdown peaks of the at least one spark plug on the basis of the accelerometric data and times of breakdown peaks of the at least one spark plug on the basis of the acoustic data representative of breakdown noises of the at least one spark plug, - correlating the times of the breakdown peaks of the at least one spark plug detected on the basis of the accelerometric data and the times of the breakdown peaks of the at least one spark plug detected on the basis of the acoustic data representative of breakdown noises of the at least one spark plug, and - establishing (E10, E12) a diagnosis of health of the ignition exciter box and a diagnosis of the at least one spark plug, according to the results of the correlation step. - acquiring (E2, E3, E6, E7) accelerometric and acoustic data representative of breakdown noises of the at least one spark plug, on the basis of signals produced by the at least one accelerometer and the at least one acoustic sensor, - detecting (E4, E8) times of breakdown peaks of the at least one spark plug on the basis of the accelerometric data and times of breakdown peaks of the at least one spark plug on the basis of the acoustic data representative of breakdown noises of the at least one spark plug, - correlating the times of the breakdown peaks of the at least one spark plug detected on the basis of the accelerometric data and the times of the breakdown peaks of the at least one spark plug detected on the basis of the acoustic data representative of breakdown noises of the at least one spark plug, and - establishing (E10, E12) a diagnosis of health of the ignition exciter box and a diagnosis of the at least one spark plug, according to the results of the correlation step.
Ventilation induction device for venting and/or air conditioning a room of a building or the like, comprising an induction device supplied with primary air, a heat exchanger through which secondary air flows due to the induction effect of the induction device, and an injector device designed as an air guide element and guiding at least a portion of the secondary air coming from the heat exchanger to the effective range of the induction device, wherein the air guide element is displaceably arranged for narrowing or widening the cross-section of an air guide zone located downstream of the induction device, wherein an air discharge duct serving to discharge primary air and/or mixed air formed from primary air and secondary air is arranged downstream of the induction device and the heat exchanger, whose inlet having the cross-section can be narrowed or widened by means of the displaceably arranged air guide element, and wherein the air guide element is displaceable from a basic position via any number of intermediate positions into a maximum position, characterized in that, by building up a counterpressure which increases from intermediate position to intermediate position and acts on the secondary air, no secondary air flows through the heat exchanger any more in the maximum position and only the entire primary air passes through the air discharge duct, wherein the air guide element lies at a distance from the heat exchanger forming a flow path for the portion of secondary air and in its basic position lies in an at least partial, lateral overlapping position with a region of the heat exchanger, wherein in the basic position of the air guide element a secondary air volume flow through the heat exchanger has a value of 100%, in an intermediate position has a value of 50% and in the maximum position has a value of 0.
A system for conditioning air within an air handling system of a building, which building has a hot water source and a cold water source, the conditioning system comprising: at least one heating-cooling unit connected to the air handling system, which unit is operable to transfer heat into or out of air passing within the air handling system of the building, and which unit includes at least one chilled beam; a primary water storage device operable to store a volume of water within a predetermined temperature range, which primary water storage device is in communication with the hot water source and the cold water source; at least one first heat pump connected to the primary water storage device and the at least one chilled beam of the heating-cooling unit; and characterised by comprising a controller adapted to selectively drive the first heat pump to transfer heat between the primary water storage device and the chilled beam of the heating-cooling unit, and adapted to selectively control the system to transfer heat into or out of the primary water storage device to maintain the water within the primary storage device within the predetermined temperature range. at least one heating-cooling unit connected to the air handling system, which unit is operable to transfer heat into or out of air passing within the air handling system of the building, and which unit includes at least one chilled beam; a primary water storage device operable to store a volume of water within a predetermined temperature range, which primary water storage device is in communication with the hot water source and the cold water source; at least one first heat pump connected to the primary water storage device and the at least one chilled beam of the heating-cooling unit; and characterised by comprising a controller adapted to selectively drive the first heat pump to transfer heat between the primary water storage device and the chilled beam of the heating-cooling unit, and adapted to selectively control the system to transfer heat into or out of the primary water storage device to maintain the water within the primary storage device within the predetermined temperature range.
A spreading machine, in particular a precision seed sowing machine, comprising - at least one seed hopper, - at least one fertilizer hopper, - a plurality of spreading units, wherein each of the spreading units has at least one separating device which is operated pneumatically using overpressure and to which a separating air flow under overpressure can be supplied, and a fertilizer application device, - a conveying air-operated seed feed device for providing seed from the seed hopper to the spreading units, wherein the separation air flow and a conveying air flow of the seed feed device can be combined in the separating device, - an energy-operated fertilizer supply device for providing fertilizer to the fertilizer application devices, - separate fans (8a, 8b, 8c) for providing the separating air flows to the separating devices, the conveying air to the seed feed device and the energy to the fertilizer supply device, respectively; - a seed dispensing channel for dispensing seeds individually; and - a press wheel which is arranged in the dispensing region out of the seed dispensing channel and is designed to transfer the seed grain after exiting the seed dispensing channel and thus to brake it. - at least one seed hopper, - at least one fertilizer hopper, - a plurality of spreading units, wherein each of the spreading units has at least one separating device which is operated pneumatically using overpressure and to which a separating air flow under overpressure can be supplied, and a fertilizer application device, - a conveying air-operated seed feed device for providing seed from the seed hopper to the spreading units, wherein the separation air flow and a conveying air flow of the seed feed device can be combined in the separating device, - an energy-operated fertilizer supply device for providing fertilizer to the fertilizer application devices, - separate fans (8a, 8b, 8c) for providing the separating air flows to the separating devices, the conveying air to the seed feed device and the energy to the fertilizer supply device, respectively; - a seed dispensing channel for dispensing seeds individually; and - a press wheel which is arranged in the dispensing region out of the seed dispensing channel and is designed to transfer the seed grain after exiting the seed dispensing channel and thus to brake it.
An electro-microneedle integrated body, comprising: an electrode for electroporation which is to be contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part; and a set of microneedles, one microneedle adhered to each electrode part and insertable into the skin of a human body each microneedle, comprising a biocompatible and biodegradable material and a genetic material, wherein each microneedle is to degrade within the skin, and an electric field pulse is to be applied through the electrode for electroporation in a site in which the microneedles are to be inserted to enable a smooth introduction of the genetic material contained in the microneedles into cells, whereby the microneedles are preparable by mixing a biocompatible and biodegradable viscous material and the genetic material into a mixed composition characterized in that the microneedles are formable by supplying the mixed composition in a liquid state onto each of the plurality of electrode parts the documents US 2002/082543 A and US 2009/131905 A disclose microneedle devices 2 for transport of molecules across the skin and methods for the preparation of such devices characterized in that protruding from the base part and congulating the mixed composition. an electrode for electroporation which is to be contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part; and a set of microneedles, one microneedle adhered to each electrode part and insertable into the skin of a human body each microneedle, comprising a biocompatible and biodegradable material and a genetic material,
Method for execution in network element of a radio communications system, comprising: receiving (302, 302a) a measurement report from a user equipment, making a decision (24, 26) to make a serving high-speed downlink shared channel cell change and to make an active set update, preparing a radio link at a target high-speed downlink shared channel cell to operate as a serving high-speed downlink shared channel radio link, sending an active set update message to the user equipment, said active set update message including information relating to the serving high-speed downlink shared channel cell change from a radio link at a source high-speed downlink shared channel cell to the radio link at the target high-speed downlink shared channel cell. receiving (302, 302a) a measurement report from a user equipment, making a decision (24, 26) to make a serving high-speed downlink shared channel cell change and to make an active set update, preparing a radio link at a target high-speed downlink shared channel cell to operate as a serving high-speed downlink shared channel radio link, sending an active set update message to the user equipment, said active set update message including information relating to the serving high-speed downlink shared channel cell change from a radio link at a source high-speed downlink shared channel cell to the radio link at the target high-speed downlink shared channel cell.
A rolling assembly, the rolling assembly including: a body; one or more surface rollers rotatable with respect to the body; and at least one rotatable sweeping device including: an elongate member rotatable with respect to the body; and a sweeping head located over the elongate member, wherein the sweeping head is configured to engage with the one or more surface rollers such that the rotation of the one or more surface rollers rotates the sweeping head, characterized in that the sweeping head is rotatable with respect to the elongate member. a body; one or more surface rollers rotatable with respect to the body; and at least one rotatable sweeping device including: an elongate member rotatable with respect to the body; and a sweeping head located over the elongate member, wherein the sweeping head is configured to engage with the one or more surface rollers such that the rotation of the one or more surface rollers rotates the sweeping head, characterized in that the sweeping head is rotatable with respect to the elongate member. an elongate member rotatable with respect to the body; and a sweeping head located over the elongate member, wherein the sweeping head is configured to engage with the one or more surface rollers such that the rotation of the one or more surface rollers rotates the sweeping head, characterized in that the sweeping head is rotatable with respect to the elongate member.
Method for manufacturing optical elements that are formable from blanks, comprising the following steps: - providing a blank for the manufacture of the optical element, - working at least one surface of the blank to approximate a desired surface contour by coarse removal of material by means of high-energy radiation, - polishing at least the worked surface with high-energy radiation, wherein polishing is carried out without material removal, - measuring a surface contour and surface roughness of the surface before and/or after polishing, and comparing it with the desired surface contour and a desired surface roughness, and - if the deviation of the measured surface contour or surface roughness from the desired surface contour and desired surface roughness is outside a respectively predetermined tolerance limit, carrying out extremely fine material removal by means of high-energy radiation, optionally alternating with polishing of the surface until the deviation of the surface contour or surface roughness from the desired surface contour and the desired surface roughness is within the predetermined tolerance limit. - providing a blank for the manufacture of the optical element, - working at least one surface of the blank to approximate a desired surface contour by coarse removal of material by means of high-energy radiation, - polishing at least the worked surface with high-energy radiation, wherein polishing is carried out without material removal, - measuring a surface contour and surface roughness of the surface before and/or after polishing, and comparing it with the desired surface contour and a desired surface roughness, and - if the deviation of the measured surface contour or surface roughness from the desired surface contour and desired surface roughness is outside a respectively predetermined tolerance limit, carrying out extremely fine material removal by means of high-energy radiation, optionally alternating with polishing of the surface until the deviation of the surface contour or surface roughness from the desired surface contour and the desired surface roughness is within the predetermined tolerance limit.
A method for mass-producing electronic devices comprising an antenna and at least one microcircuit connected to said antenna allowing wireless communication, said method comprising a step of producing a plurality of planar antennae on the same support using wired technology, where at least two antennae on said support are formed following a continuous uninterrupted process of dispensing the same wire, characterised in that said method comprises, for a first antenna, fixing said wire in said support at a first point, passing the wire onto the location of a first contact pad of said microcircuit, dispensing the wire so as to form one or more loops in said surface, passing the wire onto the location of a second contact pad of said microcircuit, fixing said wire in said support at a second point downstream of said location of said second contact, then dispensing said wire up to the first fixing point of a subsequent antenna on said support.
A vehicle parking payment system, comprising: a digital license plate (11, 602) attached to an exterior of a vehicle, the digital license plate having a display, and being wirelessly connectable to send and receive data; wherein the digital license plate comprises a processing device programmed to: detect (702, 704) parking of the vehicle; wirelessly search for information or data provided by at least one of a parking related facility, meter, and fine system; request authorization to pay parking related payments to a payment authority; send the authorization to pay parking related payments to a payment authority, with the authorization at least partially incorporating information stored in the digital license plate; and present on the display a visual indicator of authorized parking of the vehicle. a digital license plate (11, 602) attached to an exterior of a vehicle, the digital license plate having a display, and being wirelessly connectable to send and receive data; wherein the digital license plate comprises a processing device programmed to: detect (702, 704) parking of the vehicle; wirelessly search for information or data provided by at least one of a parking related facility, meter, and fine system; request authorization to pay parking related payments to a payment authority; send the authorization to pay parking related payments to a payment authority, with the authorization at least partially incorporating information stored in the digital license plate; and present on the display a visual indicator of authorized parking of the vehicle. detect (702, 704) parking of the vehicle; wirelessly search for information or data provided by at least one of a parking related facility, meter, and fine system; request authorization to pay parking related payments to a payment authority; send the authorization to pay parking related payments to a payment authority, with the authorization at least partially incorporating information stored in the digital license plate; and present on the display a visual indicator of authorized parking of the vehicle.
An aerosol generating article (10, 100) comprising: an aerosol generating substrate (12, 124) comprising nicotine and at least about 10% aerosol former comprising glycerine; and a first paper layer (50, 500) disposed about the aerosol generating substrate, the first paper layer having a first thickness/grammage value; and a second paper layer (20, 110) disposed about the first paper layer, the second paper layer having a second thickness/grammage value, the first thickness/grammage value being less that than the second thickness/grammage value. an aerosol generating substrate (12, 124) comprising nicotine and at least about 10% aerosol former comprising glycerine; and a first paper layer (50, 500) disposed about the aerosol generating substrate, the first paper layer having a first thickness/grammage value; and a second paper layer (20, 110) disposed about the first paper layer, the second paper layer having a second thickness/grammage value, the first thickness/grammage value being less that than the second thickness/grammage value.