A tube pump system comprising: a tube pump comprising: a housing unit which has an inner peripheral surface formed into a circular-arc shape around an axis line; a tube having flexibility which is arranged along the inner peripheral surface; a pair of roller units (10, 20) which are housed in the housing unit, and are rotated around the axis line from a contact position (Pol) to a separate position around the axis line in a state where the pair of roller units (10, 20) compress the tube; a pair of drive units (50, 60) which are configured to rotate the pair of roller units (10, 20) respectively around the axis line in a same direction; and a control unit which is configured to control each of the pair of drive units (50, 60) such that a liquid which flows into the tube from one end of the tube is discharged from the other end of the tube, characterized in that the tube pump further comprising: a pipe having flexibility and being connected to the other end of the tube, the pipe maintaining a pressure of the liquid flowing through the inside of the pipe at a first predetermined pressure higher than an atmospheric pressure; a pressure sensor that detects a pressure of the liquid flowing through the pipe; a needle valve or an orifice that adjusts a pressure of the liquid flowing through the pipe arranged on the upstream side of the needle valve; and the control unit is configured to control each of the pair of drive units (50, 60) such that a pressure of the liquid in the tube which is closed due to a contact of the pair of roller units (10, 20) is increased to a second predetermined pressure having a predetermined pressure difference with respect to the first predetermined pressure when one of the pair of roller units (10, 20) passes the separate position. a housing unit which has an inner peripheral surface formed into a circular-arc shape around an axis line; a tube having flexibility which is arranged along the inner peripheral surface; a pair of roller units (10, 20) which are housed in the housing unit, and are rotated around the axis line from a contact position (Pol) to a separate position around the axis line in a state where the pair of roller units (10, 20) compress the tube; a pair of drive units (50, 60) which are configured to rotate the pair of roller units (10, 20) respectively around the axis line in a same direction; and a control unit which is configured to control each of the pair of drive units (50, 60) such that a liquid which flows into the tube from one end of the tube is discharged from the other end of the tube, characterized in that the tube pump further comprising: a pipe having flexibility and being connected to the other end of the tube, the pipe maintaining a pressure of the liquid flowing through the inside of the pipe at a first predetermined pressure higher than an atmospheric pressure; a pressure sensor that detects a pressure of the liquid flowing through the pipe; a needle valve or an orifice that adjusts a pressure of the liquid flowing through the pipe arranged on the upstream side of the needle valve; and the control unit is configured to control each of the pair of drive units (50, 60) such that a pressure of the liquid in the tube which is closed due to a contact of the pair of roller units (10, 20) is increased to a second predetermined pressure having a predetermined pressure difference with respect to the first predetermined pressure when one of the pair of roller units (10, 20) passes the separate position. a pipe having flexibility and being connected to the other end of the tube, the pipe maintaining a pressure of the liquid flowing through the inside of the pipe at a first predetermined pressure higher than an atmospheric pressure; a pressure sensor that detects a pressure of the liquid flowing through the pipe; a needle valve or an orifice that adjusts a pressure of the liquid flowing through the pipe arranged on the upstream side of the needle valve; and the control unit is configured to control each of the pair of drive units (50, 60) such that a pressure of the liquid in the tube which is closed due to a contact of the pair of roller units (10, 20) is increased to a second predetermined pressure having a predetermined pressure difference with respect to the first predetermined pressure when one of the pair of roller units (10, 20) passes the separate position.