An antimicrobial composition comprising: 0.01 wt-% to 20 wt-% of an antimicrobial lipid component comprising a (C8-C22)unsaturated fatty acid ester of a polyhydric alcohol, an alkoxylated derivative thereof, or combinations thereof, wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of polyhydric alcohol; with the proviso that for polyhydric alcohols other than sucrose, the esters comprise monoesters, and for sucrose the esters comprise monoesters, diesters, or combinations thereof; 0.01 wt-% to 20 wt-% of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, or combinations thereof; 0.1 wt-% to 10 wt-% of a surfactant distinct from the antimicrobial lipid component, wherein the surfactant comprises a sulfonate, a sulfate, a phosphonate, a phosphate, a poloxamer, a cationic surfactant, an amphoteric surfactant, an alkyl or alkylamidoalkyldialkylamine oxide of the following formula: (R 14) 3 -N→O wherein R 14 is a (C1-C30)alkyl group or a (C6-C18)aralklyl or alkaryl group, wherein any of these groups can be optionally substituted in or on the chain by N-, O-, or S-containing groups, or mixtures thereof; 1 wt-% to 40 wt-% of a hydrophilic component including a polyhydric alcohol; 50 wt-% to 95 wt-% of a hydrophobic component selected from the group consisting of petrolatum USP; (C1-C6) alkyl or (C6-C12) aryl esters of (C8-C36) straight or branched chain alkyl or alkenyl alcohols or acids and polyethoxylated derivatives of the alcohols; (C1-C6) alkyl or (C6-C12) aryl esters of (C4-C12) diacids or (C4-C12) diols optionally substituted in available positions by -OH; (C1-C9) alkyl or (C6-C12) aryl esters of glycerol, pentaerythritol, ethylene glycol, and propylene glycol; and mixtures thereof; and less than 10 wt-% water. 0.01 wt-% to 20 wt-% of an antimicrobial lipid component comprising a (C8-C22)unsaturated fatty acid ester of a polyhydric alcohol, an alkoxylated derivative thereof, or combinations thereof, wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of polyhydric alcohol; with the proviso that for polyhydric alcohols other than sucrose, the esters comprise monoesters, and for sucrose the esters comprise monoesters, diesters, or combinations thereof; 0.01 wt-% to 20 wt-% of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, or combinations thereof; 0.1 wt-% to 10 wt-% of a surfactant distinct from the antimicrobial lipid component, wherein the surfactant comprises a sulfonate, a sulfate, a phosphonate, a phosphate, a poloxamer, a cationic surfactant, an amphoteric surfactant, an alkyl or alkylamidoalkyldialkylamine oxide of the following formula: (R 14) 3 -N→O wherein R 14 is a (C1-C30)alkyl group or a (C6-C18)aralklyl or alkaryl group, wherein any of these groups can be optionally substituted in or on the chain by N-, O-, or S-containing groups, or mixtures thereof; 1 wt-% to 40 wt-% of a hydrophilic component including a polyhydric alcohol; 50 wt-% to 95 wt-% of a hydrophobic component selected from the group consisting of petrolatum USP; (C1-C6) alkyl or (C6-C12) aryl esters of (C8-C36) straight or branched chain alkyl or alkenyl alcohols or acids and polyethoxylated derivatives of the alcohols; (C1-C6) alkyl or (C6-C12) aryl esters of (C4-C12) diacids or (C4-C12) diols optionally substituted in available positions by -OH; (C1-C9) alkyl or (C6-C12) aryl esters of glycerol, pentaerythritol, ethylene glycol, and propylene glycol; and mixtures thereof; and less than 10 wt-% water.