mhurhangee/ep-ind-claims huggingface dataset:
A method of determining whether an individual eligible to receive an IL-2-based therapy may experience an adverse event associated with the IL-2-based therapy, the method comprising: (a) measuring the expression levels of at least two biomarkers selected from a panel of biomarkers in a blood, plasma or serum sample obtained from the individual, wherein the sample is combined with IL-2 in vitro before IL-2-based therapy, and wherein the panel of biomarkers consists of TGFβ1, PLEKHA6, CTSB, FERMT1, CRMP1, VEGFB, VEGFA, and PLEKHA1; and (b) comparing the levels of the biomarkers to reference levels, wherein an increase in the levels above the reference levels indicates that the individual may experience an adverse event associated with the IL-2-based therapy, and wherein a decrease or no change in the levels compared to the references levels indicates that the individual may not experience an adverse event associated with the IL-2-based therapy. (a) measuring the expression levels of at least two biomarkers selected from a panel of biomarkers in a blood, plasma or serum sample obtained from the individual, wherein the sample is combined with IL-2 in vitro before IL-2-based therapy, and wherein the panel of biomarkers consists of TGFβ1, PLEKHA6, CTSB, FERMT1, CRMP1, VEGFB, VEGFA, and PLEKHA1; and (b) comparing the levels of the biomarkers to reference levels, wherein an increase in the levels above the reference levels indicates that the individual may experience an adverse event associated with the IL-2-based therapy, and wherein a decrease or no change in the levels compared to the references levels indicates that the individual may not experience an adverse event associated with the IL-2-based therapy.
An anti-cancer bioactive peptide comprising the amino acid sequence as shown in SEQ No. 1 or SEQ No. 2 or SEQ No. 3 or SEQ No. 4, or an anti-cancer bioactive peptide consisting of the amino acid sequence of SEQ No. 5.
A terminal apparatus comprising: a transmitter configured to map a PUSCH to a SC-FDMA symbol of a special subframe, based on an RRC layer parameter number of data symbols for PUSCH in UpPTS, symPUSCH_UpPTS, to transmit the PUSCH, wherein the special subframe includes at least a Guard Period, GP, field and an Uplink Pilot Time Slot, UpPTS, field; and a transmit power control unit configured to determine the power control adjustment for the current PUSCH transmission parameter f c (i), based on at least whether the RRC layer parameter symPUSCH UpPTS is configured for the terminal apparatus, and calculate transmit power for PUSCH transmission in a subframe i, based on at least the parameter f c (i), wherein the parameter f c (i) is given based on the equation: f c i = f c i − 1 + δ PUSCH, c i − K PUSCH, wherein δ PUSCH,c is a correction value received in a DCI format and is referred to as a TPC command, and wherein: in a case that the RRC layer parameter symPUSCH_UpPTS is not configured for the terminal apparatus, and the subframe i is not an uplink subframe, δ PUSCH,c is set to 0, and in a case that the RRC layer parameter symPUSCH_UpPTS is configured for the terminal apparatus, and the subframe i is a downlink subframe, δ PUSCH,c is set to 0. a transmitter configured to map a PUSCH to a SC-FDMA symbol of a special subframe, based on an RRC layer parameter number of data symbols for PUSCH in UpPTS, symPUSCH_UpPTS, to transmit the PUSCH, wherein the special subframe includes at least a Guard Period, GP, field and an Uplink Pilot Time Slot, UpPTS, field; and a transmit power control unit configured to determine the power control adjustment for the current PUSCH transmission parameter f c (i), based on at least whether the RRC layer parameter symPUSCH UpPTS is configured for the terminal apparatus, and calculate transmit power for PUSCH transmission in a subframe i, based on at least the parameter f c (i), wherein the parameter f c (i) is given based on the equation: f c i = f c i − 1 + δ PUSCH, c i − K PUSCH, wherein δ PUSCH,c is a correction value received in a DCI format and is referred to as a TPC command, and wherein: in a case that the RRC layer parameter symPUSCH_UpPTS is not configured for the terminal apparatus, and the subframe i is not an uplink subframe, δ PUSCH,c is set to 0, and in a case that the RRC layer parameter symPUSCH_UpPTS is configured for the terminal apparatus, and the subframe i is a downlink subframe, δ PUSCH,c is set to 0. in a case that the RRC layer parameter symPUSCH_UpPTS is not configured for the terminal apparatus, and the subframe i is not an uplink subframe, δ PUSCH,c is set to 0, and in a case that the RRC layer parameter symPUSCH_UpPTS is configured for the terminal apparatus, and the subframe i is a downlink subframe, δ PUSCH,c is set to 0.
A light-emitting device (10, 10A through 10D) comprising: a board holding an end of a connection terminal (20a, 20b, 120a, 120b) and on which an electronic component is mounted; a light-emitting element mounted on a surface of the board; a support member (22, 122) on which the board is placed; and a cover (24, 78, 100, 110) positioning and holding the board by being mounted in the support member (22, 122) while in abutment against the surface of the board; wherein the cover (24, 78, 100, 110) has a main cover body covering the surface of the board; and a light guide (66, 79, 102, 112) for passing therethrough light emitted from the light-emitting element is disposed on the main cover body while being prevented from moving along a direction to sandwich the board, characterized in that the cover (24, 78, 100, 110) has a pair of protrusions (62a, 62b) positioned such that the light-emitting element is interposed between the protrusions (62a, 62b), the protrusions (62a, 62b) being integrally formed with the main cover body; the protrusions (62a, 62b) include ridges (68a, 68b) abutting against the surface of the board, and first engaging portions (70a through 70d); and the support member (22, 122) has a chamber defined therein by a wall for accommodating the board and the cover (24, 78, 100, 110), and also has second engaging portions (52a through 52d) for engaging with the first engaging portions (70a through 70d), and the first engaging portions (70a through 70d) engage with the second engaging portions (52a through 52d) to thereby position and hold the board with the cover (24, 78, 100, 110), and the wall includes: a bottom surface; and a pair of steps (42a, 42b) rising from the bottom surface; and the board has another surface spaced from the bottom surface and placed on upper surfaces of the steps (42a, 42b). a board holding an end of a connection terminal (20a, 20b, 120a, 120b) and on which an electronic component is mounted; a light-emitting element mounted on a surface of the board; a support member (22, 122) on which the board is placed; and a cover (24, 78, 100, 110) positioning and holding the board by being mounted in the support member (22, 122) while in abutment against the surface of the board; wherein the cover (24, 78, 100, 110) has a main cover body covering the surface of the board; and a light guide (66, 79, 102, 112) for passing therethrough light emitted from the light-emitting element is disposed on the main cover body while being prevented from moving along a direction to sandwich the board, a bottom surface; and a pair of steps (42a, 42b) rising from the bottom surface; and the board has another surface spaced from the bottom surface and placed on upper surfaces of the steps (42a, 42b).
Stage light fixture comprising: a casing; a frame coupled to the casing; a light source, which is arranged inside the casing at a closed end of the casing, is supported by the frame, and emits a light beam substantially along an optical axis; the light source comprising a short arc lamp extending along the optical axis and comprising an attachment basis, a front tubular portion, a rear tubular portion, axially opposite to the front tubular portion and coupled to the basis, and a central bulb arranged between the front tubular portion and the rear tubular portion; a reflector, which is coupled to the light source and has an outer edge and a central hole housing the rear tubular portion of the light source;and a cooling assembly for cooling the light source; the stage light fixture being characterized in that the cooling assembly comprises at least one cooling device (22; 24) configured to produce a cooling air flow through an outlet opening (23; 25); the outlet opening (23; 25) having an elongated shape along a main axis (C1; C2) and a further cooling device (24; 22) configured to produce a further cooling air flow through a further outlet opening (25; 23); the further outlet opening (25; 23) having an elongated shape along a further main axis (C2; C1); wherein the first cooling device is supported by the frame so that the outlet opening is close to the hole of the reflector and the further cooling device is supported by the frame so that the further outlet opening is close to the outer edge of the reflector. a casing; a frame coupled to the casing; a light source, which is arranged inside the casing at a closed end of the casing, is supported by the frame, and emits a light beam substantially along an optical axis; the light source comprising a short arc lamp extending along the optical axis and comprising an attachment basis, a front tubular portion, a rear tubular portion, axially opposite to the front tubular portion and coupled to the basis, and a central bulb arranged between the front tubular portion and the rear tubular portion; a reflector, which is coupled to the light source and has an outer edge and a central hole housing the rear tubular portion of the light source;and a cooling assembly for cooling the light source; the stage light fixture being characterized in that the cooling assembly comprises at least one cooling device (22; 24) configured to produce a cooling air flow through an outlet opening (23; 25); the outlet opening (23; 25) having an elongated shape along a main axis (C1; C2) and a further cooling device (24; 22) configured to produce a further cooling air flow through a further outlet opening (25; 23); the further outlet opening (25; 23) having an elongated shape along a further main axis (C2; C1); wherein the first cooling device is supported by the frame so that the outlet opening is close to the hole of the reflector and the further cooling device is supported by the frame so that the further outlet opening is close to the outer edge of the reflector.
A foldable outer packaging for a medical product with: - a base plate, which is divided into three segments (6a, 6b, 6c) via two parallel spaced folding fold lines (10, 11), - a pivot plate, which - is coupled to the base plate via a pivoting fold line aligned perpendicular to the folding fold lines (10, 11), - is also subdivided into three segments (5a, 5b, 5c) via the folding fold lines (10, 11) extending in a straight line into the pivot plate, and - has a window-like cut-out (or aperture) in the middle of the three segments (5a, 5b, 5c), and - a side plate, which - is coupled to the pivot plate via a turn-over fold line aligned parallel to the pivoting fold line, and - is also divided into three segments (7a, 7b, 7c) via the folding fold lines (10, 11) that continue to extend in a straight line into the side plate, wherein the pivoting fold line extends over the entire length of the base plate and of the pivot plate, characterized in that the middle one of the three segments (6a, 6b, 6c) of the base plate has a cutting pattern in the form of a plurality of individual longitudinal cuts. - a base plate, which is divided into three segments (6a, 6b, 6c) via two parallel spaced folding fold lines (10, 11), - a pivot plate, which - is coupled to the base plate via a pivoting fold line aligned perpendicular to the folding fold lines (10, 11), - is also subdivided into three segments (5a, 5b, 5c) via the folding fold lines (10, 11) extending in a straight line into the pivot plate, and - has a window-like cut-out (or aperture) in the middle of the three segments (5a, 5b, 5c), and - is coupled to the base plate via a pivoting fold line aligned perpendicular to the folding fold lines (10, 11), - is also subdivided into three segments (5a, 5b, 5c) via the folding fold lines (10, 11) extending in a straight line into the pivot plate, and - has a window-like cut-out (or aperture) in the middle of the three segments (5a, 5b, 5c), and - a side plate, which - is coupled to the pivot plate via a turn-over fold line aligned parallel to the pivoting fold line, and - is also divided into three segments (7a, 7b, 7c) via the folding fold lines (10, 11) that continue to extend in a straight line into the side plate, wherein the pivoting fold line extends over the entire length of the base plate and of the pivot plate, characterized in that the middle one of the three segments (6a, 6b, 6c) of the base plate has a cutting pattern in the form of a plurality of individual longitudinal cuts. - is coupled to the pivot plate via a turn-over fold line aligned parallel to the pivoting fold line, and - is also divided into three segments (7a, 7b, 7c) via the folding fold lines (10, 11) that continue to extend in a straight line into the side plate, wherein the pivoting fold line extends over the entire length of the base plate and of the pivot plate, characterized in that the middle one of the three segments (6a, 6b, 6c) of the base plate has a cutting pattern in the form of a plurality of individual longitudinal cuts.
A method for both the detection of the occurrence of initiation of replication events in genomic DNA, which is mitochondrial genomic DNA, and the detection of mitochondrial DNA transcription in a eukaryotic cell, comprising the steps of: - contacting said eukaryotic cell comprising mitochondrial genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the mitochondrial DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said mitochondrial DNA genome, said first nucleotide probe being specific for a segment of non transcribed mitochondrial gDNA and comprises or consists of: i. the nucleic acid having the sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, or, ii. a nucleic acid that has at least 80% identity with the nucleic acid sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, said nucleic acid molecule being either a single stand molecule or a double strand molecule, and, - contacting said eukaryotic cell with at least a second nucleotide probe targeting at least one mitochondrial RNA molecule corresponding to a transcribed region of a mitochondrial DNA molecule in the cell, and - detecting said first nucleotide probe hybridized to said mitochondrial DNA and said second nucleotide probe hybridized to said mitochondrial RNA molecule. - contacting said eukaryotic cell comprising mitochondrial genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the mitochondrial DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said mitochondrial DNA genome, said first nucleotide probe being specific for a segment of non transcribed mitochondrial gDNA and comprises or consists of: i. the nucleic acid having the sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, or, ii. a nucleic acid that has at least 80% identity with the nucleic acid sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, said nucleic acid molecule being either a single stand molecule or a double strand molecule, and, i. the nucleic acid having the sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, or, ii. a nucleic acid that has at least 80% identity with the nucleic acid sequence of any one of SEQ ID N°1 to SEQ ID N°16 or a complement thereof, - contacting said eukaryotic cell with at least a second nucleotide probe targeting at least one mitochondrial RNA molecule corresponding to a transcribed region of a mitochondrial DNA molecule in the cell, and - detecting said first nucleotide probe hybridized to said mitochondrial DNA and said second nucleotide probe hybridized to said mitochondrial RNA molecule.
A plough, in particular reversible plough, for the partial topsoil deepening having a plough frame and a pivoting device for pivoting the plough frame, wherein on the plough frame at same distances, in particular at least four plough bodies (5, 6) are pivotably arranged on swing pockets (21, 23) by means of stalks (32, 33), wherein the plough bodies (5, 6) on the plough frame are each configured as a shaft-forming first plough body and a conventional second plough body, wherein a working width of the conventional second plough body is greater than that of a shaft-forming first plough body, and a working depth of a shaft-forming first plough body is greater than the working depth of a conventional second plough body, characterised in that the swing pockets (21, 23) comprise bearing plates (22, 24), with which the swing pockets (21, 23) are, in particular releasably, arranged on the plough frame, wherein first bearing plates of the first plough body have a greater width than second bearing plates of the second plough body.
A joint driving apparatus comprising: a housing unit provided to a first link; a driving unit housed in the housing unit and adapted to rotationally drive a second link, an output end of the driving unit being connected to the second link; a bearing provided in the housing unit, the bearing being adapted to rotatably support the second link and configured to couple the second link to the housing unit; and a supporting unit comprising a holding member, being configured to couple the driving unit to the housing unit and configured to support the driving unit on the housing unit, the supporting unit comprising a torque detection apparatus comprising an elastic body configured to deform to a rotating direction of the second link and a sensor configured to detect torque generated on the supporting unit, wherein the driving unit further comprises a driving source and a reduction mechanism, characterized in that the holding member is provided between the driving source and the reduction mechanism, and the supporting unit is provided within the housing unit and between the driving unit and the housing unit, and the supporting unit couples the driving unit to the housing unit via the torque detection apparatus being joined at one end to the holding member and at the other end to the housing unit. a housing unit provided to a first link; a driving unit housed in the housing unit and adapted to rotationally drive a second link, an output end of the driving unit being connected to the second link; a bearing provided in the housing unit, the bearing being adapted to rotatably support the second link and configured to couple the second link to the housing unit; and a supporting unit comprising a holding member, being configured to couple the driving unit to the housing unit and configured to support the driving unit on the housing unit, the supporting unit comprising a torque detection apparatus comprising an elastic body configured to deform to a rotating direction of the second link and a sensor configured to detect torque generated on the supporting unit, wherein the driving unit further comprises a driving source and a reduction mechanism, characterized in that the holding member is provided between the driving source and the reduction mechanism, and the supporting unit is provided within the housing unit and between the driving unit and the housing unit, and the supporting unit couples the driving unit to the housing unit via the torque detection apparatus being joined at one end to the holding member and at the other end to the housing unit.
A method of detecting a genomic fusion event, comprising: a. contacting a sample comprising DNA molecules of interest (DMOIs) with a pool of at least 20 region-specific forward primers and a pool of at least 20 region-specific reverse primers, wherein: i. each of the forward primers in the forward primer pool comprises a sequence specific for a first region of interest and a first primer binding site; ii. each of the reverse primers in the reverse primer pool comprises a sequence specific for a second, different, region of interest and a second primer binding site; and iii. wherein the forward and reserve primers tile their respective regions at intervals of up to about 100 base pairs; b. amplifying the DMOIs using the region-specific primers; c. conducting PCR using forward primers that target the first primer binding site and reverse primers that target the second primer binding site; d. sequencing the PCR amplification product to provide a library of sequence reads, wherein the sequence reads comprise the sequence of a forward and/or reverse primer used in step (a); e. using the sequence reads provided in step (d) to determine the sequence of the genomic fusion between the first and second regions of interest. a. contacting a sample comprising DNA molecules of interest (DMOIs) with a pool of at least 20 region-specific forward primers and a pool of at least 20 region-specific reverse primers, wherein: i. each of the forward primers in the forward primer pool comprises a sequence specific for a first region of interest and a first primer binding site; ii. each of the reverse primers in the reverse primer pool comprises a sequence specific for a second, different, region of interest and a second primer binding site; and iii. wherein the forward and reserve primers tile their respective regions at intervals of up to about 100 base pairs; i. each of the forward primers in the forward primer pool comprises a sequence specific for a first region of interest and a first primer binding site; ii. each of the reverse primers in the reverse primer pool comprises a sequence specific for a second, different, region of interest and a second primer binding site; and iii. wherein the forward and reserve primers tile their respective regions at intervals of up to about 100 base pairs; b. amplifying the DMOIs using the region-specific primers; c. conducting PCR using forward primers that target the first primer binding site and reverse primers that target the second primer binding site; d. sequencing the PCR amplification product to provide a library of sequence reads, wherein the sequence reads comprise the sequence of a forward and/or reverse primer used in step (a); e. using the sequence reads provided in step (d) to determine the sequence of the genomic fusion between the first and second regions of interest.
A surface-coated cutting tool comprising a tool substrate, and a single-component coating layer composed of a composite nitride of Cr, Al, and V and disposed on the surface of the tool substrate, wherein the composite nitride being represented by a compositional formula: Cr a Al b V c N satisfying the following relations: 0.11 ≤ a ≤ 0.26; 0.73 ≤ b ≤ 0.85; 0 < c ≤ 0.04; and a + b + c = 1 (wherein a, b, and c each represent an atomic proportion), wherein the single-component coating layer has both a hexagonal phase and a cubic phase.