A valve opening and closing system for remotely controlling opening and closing operations of a manual valve arranged on site, from a center control side, the valve opening and closing system comprising: a site/center switching manual valve that is configured to switch between a site side or a center control side to perform operation of the manual valve; a manual valve for opening and closing operation that is configured to perform opening and closing operation of the manual valve on site; an opening/closing switching electric driving valve that is configured to enable the opening and closing operations of the manual valve based on a driving signal, and that is configured to nullify the manual valve for opening and closing operation during a closing operation; a center wireless transmitter that is configured to wirelessly accept and transmit an operation instruction including an opening and closing operation instruction instructing an opening operation or a closing operation, and a forced closing operation instruction instructing a forced closing operation; and a site side valve control device that includes a receiving unit which is configured to receive the operation instruction wirelessly, and a converting unit which is configured to output a driving signal to the opening/closing switching electric driving valve based on the operation instruction, wherein the site side valve control device includes an interlock unit that is configured to: acquire a switching state of the site/center switching manual valve, transmit both of the opening and closing operation instruction and the forced closing operation instruction received by the receiving unit to the converting unit in a case where the site/center switching manual valve is switched to the center control side, and interrupt the opening and closing operation instruction received by the receiving unit and transmit the forced closing operation instruction to the converting unit in a case where the site/center switching manual valve is switched to on site. a site/center switching manual valve that is configured to switch between a site side or a center control side to perform operation of the manual valve; a manual valve for opening and closing operation that is configured to perform opening and closing operation of the manual valve on site; an opening/closing switching electric driving valve that is configured to enable the opening and closing operations of the manual valve based on a driving signal, and that is configured to nullify the manual valve for opening and closing operation during a closing operation; a center wireless transmitter that is configured to wirelessly accept and transmit an operation instruction including an opening and closing operation instruction instructing an opening operation or a closing operation, and a forced closing operation instruction instructing a forced closing operation; and a site side valve control device that includes a receiving unit which is configured to receive the operation instruction wirelessly, and a converting unit which is configured to output a driving signal to the opening/closing switching electric driving valve based on the operation instruction, wherein the site side valve control device includes an interlock unit that is configured to: acquire a switching state of the site/center switching manual valve, transmit both of the opening and closing operation instruction and the forced closing operation instruction received by the receiving unit to the converting unit in a case where the site/center switching manual valve is switched to the center control side, and interrupt the opening and closing operation instruction received by the receiving unit and transmit the forced closing operation instruction to the converting unit in a case where the site/center switching manual valve is switched to on site. acquire a switching state of the site/center switching manual valve, transmit both of the opening and closing operation instruction and the forced closing operation instruction received by the receiving unit to the converting unit in a case where the site/center switching manual valve is switched to the center control side, and interrupt the opening and closing operation instruction received by the receiving unit and transmit the forced closing operation instruction to the converting unit in a case where the site/center switching manual valve is switched to on site.