mhurhangee/ep-ind-claims huggingface dataset:
An antibody-antibiotic conjugate compound comprising an anti-wall teichoic acid monoclonal antibody, wherein the anti-wall teichoic acid monoclonal antibody binds to Staphylococcus aureus, and covalently attached to a rifamycin-type antibiotic by a S. aureus endopeptidase or cysteine protease cleavable, peptide linker, the antibody-antibiotic conjugate compound is selected from the formulas: wherein R 5 is independently selected from H and C 1 -C 12 alkyl; and n is 0 or 1; and wherein R 3 is independently selected from H and C 1 -C 12 alkyl; and n is 1 or 2; wherein R is H, C 1 -C 12 alkyl, or C CH 3; L is the peptide linker having the formula: -Str-Pep-Y- where Str is a stretcher unit; Pep is a peptide of two to twelve amino acid residues, and Y is a spacer unit; Ab is the anti-wall teichoic acid monoclonal antibody; and p is an integer from 1 to 8; wherein the VL of the anti-WTA monoclonal_antibody comprises-CDR L1 comprising the sequence of KSSQSIFRTSRNKNLLN (SEQ ID NO:99), CDR L2 comprising the sequence of WASTRKS (SEQ ID NO:100), and CDR L3 comprising the sequence of QQYFSPPYT (SEQ ID NO:101); and the VH of the anti-WTA monoclonal antibody comprises CDR H1 comprising the sequence of SFWMH (SEQ ID NO:102), CDR H2 comprising the sequence of FTNNEGTTTAYADSVRG (SEQ ID NO: 103), and CDR H3 comprising the sequence of GEGGLDD (SEQ ID NO:118) or GDGGLDD (SEQ ID NO:104). R 5 is independently selected from H and C 1 -C 12 alkyl; and n is 0 or 1; and R 3 is independently selected from H and C 1 -C 12 alkyl; and n is 1 or 2; wherein R is H, C 1 -C 12 alkyl, or C CH 3; L is the peptide linker having the formula: where Str is a stretcher unit; Pep is a peptide of two to twelve amino acid residues, and Y is a spacer unit; Ab is the anti-wall teichoic acid monoclonal antibody; and p is an integer from 1 to 8; wherein the VL of the anti-WTA monoclonal_antibody comprises-CDR L1 comprising the sequence of KSSQSIFRTSRNKNLLN (SEQ ID NO:99), CDR L2 comprising the sequence of WASTRKS (SEQ ID NO:100), and CDR L3 comprising the sequence of QQYFSPPYT (SEQ ID NO:101); and the VH of the anti-WTA monoclonal antibody comprises CDR H1 comprising the sequence of SFWMH (SEQ ID NO:102), CDR H2 comprising the sequence of FTNNEGTTTAYADSVRG (SEQ ID NO: 103), and CDR H3 comprising the sequence of GEGGLDD (SEQ ID NO:118) or GDGGLDD (SEQ ID NO:104).
A computer-implemented method for providing output data comprising an indication regarding the affliction of a patient with an infectious respiratory disease, comprising the following steps: - receiving magnetic resonance imaging data acquired using a magnetic resonance imaging system, wherein the magnetic resonance imaging data comprise a lung region of the patient, - applying a trained function to the magnetic resonance imaging data, wherein output data are generated, wherein the trained function is based on an artificial neural network and the output data comprise the indication regarding the affliction of the patient with the infectious respiratory disease, - providing the output data, characterized in that the indication regarding the affliction of the patient with the infectious respiratory disease comprises an indication whether the patient is afflicted with post-acute condition following the acute infection with the infectious respiratory disease. - receiving magnetic resonance imaging data acquired using a magnetic resonance imaging system, wherein the magnetic resonance imaging data comprise a lung region of the patient, - applying a trained function to the magnetic resonance imaging data, wherein output data are generated, wherein the trained function is based on an artificial neural network and the output data comprise the indication regarding the affliction of the patient with the infectious respiratory disease, - providing the output data,
A server comprising: a communication interface; a processor operatively connected to the communication interface; and a memory operatively connected to the processor and configured to store a plurality of natural language understanding, NLU, models and instructions that, when executed by the processor, cause the processor to: receive first information associated with a user from an external electronic device associated with a user account using the communication interface, wherein the first information includes a voice input of the user; determine an intent corresponding to the voice input; identify at least one of the plurality of NLU models based on at least part of the first information; when the intent corresponding to the voice input is recognized more than a specified number of times, select at least one of the plurality of NLU models based on at least one voice input corresponding to the intent corresponding to the voice input; and transmit the selected at least one of the plurality of NLU models to the external electronic device using the communication interface. a communication interface; a processor operatively connected to the communication interface; and a memory operatively connected to the processor and configured to store a plurality of natural language understanding, NLU, models and instructions that, when executed by the processor, cause the processor to: receive first information associated with a user from an external electronic device associated with a user account using the communication interface, wherein the first information includes a voice input of the user; determine an intent corresponding to the voice input; identify at least one of the plurality of NLU models based on at least part of the first information; when the intent corresponding to the voice input is recognized more than a specified number of times, select at least one of the plurality of NLU models based on at least one voice input corresponding to the intent corresponding to the voice input; and transmit the selected at least one of the plurality of NLU models to the external electronic device using the communication interface. receive first information associated with a user from an external electronic device associated with a user account using the communication interface, wherein the first information includes a voice input of the user; determine an intent corresponding to the voice input; identify at least one of the plurality of NLU models based on at least part of the first information; when the intent corresponding to the voice input is recognized more than a specified number of times, select at least one of the plurality of NLU models based on at least one voice input corresponding to the intent corresponding to the voice input; and transmit the selected at least one of the plurality of NLU models to the external electronic device using the communication interface.
Discharge device for a nasal dispenser for nasal administration of a liquid medium, comprising - a housing with a coupling geometry for mounting on a liquid storage unit, and - an applicator tip in the form of a nosepiece with a discharge opening arranged at a distal end, wherein an external thread is provided on an outer circumferential face of the nosepiece in order to permit mounting of a protective cap provided with an internal thread, and the discharge device comprises an actuation unit which is displaceable in an axial direction in relation to the housing and has a finger support surface to which the nosepiece is connected in a positionally fixed manner, wherein liquid originating from the liquid storage unit can be dispensed through the discharge opening into a surrounding atmosphere by means of the actuation unit, characterized in that at least one counter-tooth is provided on the applicator tip above a finger support surface and serves to interact with a locking tooth on the protective cap, wherein this interaction entails that, during a rotation of the protective cap relative to the applicator tip in a first direction for screwing on the protective cap, the at least one locking tooth overruns the at least one counter-tooth and, after it has overrun the latter, the at least one locking tooth and the at least one counter-tooth prevent a rotation in the direction, opposite to the first direction, for unscrewing the protective cap. - a housing with a coupling geometry for mounting on a liquid storage unit, and - an applicator tip in the form of a nosepiece with a discharge opening arranged at a distal end,
A process for coagulating a sulfonated block copolymer from a solution comprising the block copolymer and one or more organic solvents, the process comprising (a) an ejection stage which comprises ejecting the copolymer solution into or onto moderately stirred water to form a coagulation mixture, wherein the ejected copolymer solution is substantially free of steam as no extraneous steam is added to the copolymer solution prior to ejection; and the water is at an operating pressure and is at an operating temperature below its boiling point; and (b) a holding stage which comprises subjecting the coagulation mixture formed in stage (a) to moderate stirring at a holding pressure and at a holding temperature below the boiling point of water for a period sufficient to substantially completely evaporate the one or more organic solvents, whereby at most residual amounts of solvent(s), i.e. at most 1 wt%, are present in the coagulation mixture, wherein the copolymer solution is ejected through one or more nozzles. (a) an ejection stage which comprises ejecting the copolymer solution into or onto moderately stirred water to form a coagulation mixture, wherein the ejected copolymer solution is substantially free of steam as no extraneous steam is added to the copolymer solution prior to ejection; and the water is at an operating pressure and is at an operating temperature below its boiling point; and (b) a holding stage which comprises subjecting the coagulation mixture formed in stage (a) to moderate stirring at a holding pressure and at a holding temperature below the boiling point of water for a period sufficient to substantially completely evaporate the one or more organic solvents, whereby at most residual amounts of solvent(s), i.e. at most 1 wt%, are present in the coagulation mixture,
Thermal differential machine with eight changes of thermodynamic cycle, comprising first and second chambers (5, 6) of thermodynamic transformations each with three sections (8, 9, 10; 11, 12, 13), where one section (8, 11) is heated, one section (9, 12) is isolated, and one section (10, 13) is cooled, said sections (8, 9, 10; 11, 12, 13) being connected in differential configuration through ducts (20, 21), a driving force element, a mass transfer element of gas, a valve selectively allowing the continuity of crankshaft rotation of the driving force element to release the inertial operation of said driving force element, and a pair of control valves (14, 15) selectively allowing the passage of working gas to the driving force element, characterized by having a first isothermal phase where gas in the first chamber is in the heated section and gas in the second chamber is in the refrigerated section, a second adiabatic phase where gas in both chambers (5, 6) is in the respective isolated sections (9, 12), a third isothermal phase where gas in the first chamber is in the cooled section and gas in the second chamber is in the heated section, and a fourth adiabatic phase where gas in both sections (5, 6) is again in the respective isolated sections (9, 12), thus providing the eight differential thermodynamic transformations.
A piece of furniture for fitting to a vehicle, the piece of furniture comprising a tray and a plurality of items of foodservice equipment (34, 36) disposed on the tray, the tray extending in a substantially horizontal plane and bounded by at least one access edge to the tray, each item of equipment (34, 36) having a front face disposed adjacent the access edge, the access edge defining a plurality of recessed regions, the front face of each piece of equipment (34, 36) facing one of the recessed regions, characterised in that each item of equipment (34, 36) is selected from a microwave oven or a coffee machine.
Method for the production of a root canal instrument, the method comprising the following method steps: - producing a sub-millimetre thick base plate from a titanium-nickel alloy or from a plastics material, such as a carbon-fibre-reinforced plastics material; - coating the base plate with a coating comprising abrasive particles; - dividing the base plate into longitudinally extending strips having a four-sided or three-sided cross-section in such a manner that at least one side (19, 20) of the four-sided or three-sided cross-section has the coating; and - twisting the strips to form a root canal drill bit having a cutting edge (22, 23) occupied by abrasive particles. - producing a sub-millimetre thick base plate from a titanium-nickel alloy or from a plastics material, such as a carbon-fibre-reinforced plastics material; - coating the base plate with a coating comprising abrasive particles; - dividing the base plate into longitudinally extending strips having a four-sided or three-sided cross-section in such a manner that at least one side (19, 20) of the four-sided or three-sided cross-section has the coating; and - twisting the strips to form a root canal drill bit having a cutting edge (22, 23) occupied by abrasive particles.
A method for preparing a beverage component, the method comprising the steps of: (a) Providing an aqueous suspension comprising at least 1.5 g/l, preferably at least 3g/l, most preferably at least 5 g/l hops or hop products; and, fermentable carbohydrates; (b) Fermenting the aqueous suspension with a yeast to obtain the beverage component, characterized in that the aqueous suspension comprises an amount of free amino nitrogen of less than 11ppm FAN/°Pl, preferably less than 6ppm FAN/°Pl, most preferably less than 4.5ppm FAN/°Pl, at the start of fermentation and/or that aqueous suspension comprises an amount of free amino nitrogen of less than 180ppm, preferably less than 100ppm, most preferably less than 85ppm. (a) Providing an aqueous suspension comprising at least 1.5 g/l, preferably at least 3g/l, most preferably at least 5 g/l hops or hop products; and, fermentable carbohydrates; (b) Fermenting the aqueous suspension with a yeast to obtain the beverage component,
A system for remote monitoring and command and control of one or more offshore aquafarms, the system comprising: at least one offshore aquafarm comprising husbandry equipment and at least one aquaculture cage; computing and networking equipment comprising network enabled devices that facilitate reliable monitoring and command and control of the husbandry equipment installed on the at least one offshore aquafarm; cloud services; and at least one uplink configured to provide connectivity between the computing and networking equipment and the cloud services; wherein the cloud services are configured to be accessed by a remote operator to monitor and control the at least one offshore aquafarm, and wherein the monitoring and controlling of the at least one offshore aquafarm comprises monitoring and controlling the husbandry equipment to schedule and execute husbandry functions, said system being characterized in that the husbandry functions comprise at least one of harvesting fish, cleaning the at least one aquaculture cage, and removing mortalities from the at least one aquaculture cage. at least one offshore aquafarm comprising husbandry equipment and at least one aquaculture cage; computing and networking equipment comprising network enabled devices that facilitate reliable monitoring and command and control of the husbandry equipment installed on the at least one offshore aquafarm; cloud services; and at least one uplink configured to provide connectivity between the computing and networking equipment and the cloud services; wherein the cloud services are configured to be accessed by a remote operator to monitor and control the at least one offshore aquafarm, and wherein the monitoring and controlling of the at least one offshore aquafarm comprises monitoring and controlling the husbandry equipment to schedule and execute husbandry functions,
A composition adapted to be applied to a surface to form a road marking, wherein the composition comprises a base composition, and coated glass beads, wherein the coated glass beads are mixed with the base composition, wherein the coated glass beads are coated with a coating material which coating material, when the composition has been applied to a surface to form a marking, is adapted to be worn off at any exposed portion of the glass bead thereby allowing light to enter into the glass bead at said exposed worn off portion and which coating material is adapted to form a retro-reflective coating reflecting light which has passed into the glass bead to be reflected back through the glass bead and out through said exposed portion where the coating has been worn off, wherein the coating material is provided in such an amount that before it is worn off, the coating is non-translucent, wherein the coating material is provided in such an amount that, when coated on premix glass beads according to EN 1424 class A having a size within 180 and 600 μm and with the coated glass beads being provided in an amount of 30% by weight in a non-pigmented reference composition, light which enters the glass bead will be retro-reflected in the area of the interface of the glass and the coating, or in the coating, to produce a reflectivity of at least 100 mcd/lux/m2 measured at a wear simulator turntable according to EN 13197 at traffic class P4.
A single crystal silicon wafer comprising: two major, parallel surfaces, one of which is a front surface of the single crystal silicon wafer and the other of which is a back surface of the single crystal silicon wafer, a circumferential edge joining the front and back surfaces of the single crystal silicon wafer, a bulk region between the front and back surfaces, and a central plane of the single crystal silicon wafer between the front and back surfaces of the single crystal silicon wafer, wherein the bulk region comprises nitrogen at a concentration of at least about 5×10 14 atoms/cm 3 and less than about 1×10 16 atoms/cm 3, germanium at a concentration of at least about 1×10 19 atoms/cm 3 and less than about 1×10 22 atoms/cm 3, or a combination of nitrogen at a concentration of at least about 5×10 14 atoms/cm 3 and less than about 1×10 16 atoms/cm 3 and germanium at a concentration of at least about 1×10 19 atoms/cm 3 and less than about 1×10 22 atoms/cm 3, and interstitial oxygen at a concentration of less than about 6 ppma (New ASTM: ASTM F 121, 1980-1983; DIN 50438/1, 1978), and further wherein the bulk region of the single crystal silicon wafer has a resistivity of at least about 10000 ohm cm.
An end effector assembly for an ultrasonic surgical instrument, the end effector assembly comprising: an ultrasonic blade mechanically coupled to an ultrasonic transducer configured to transmit ultrasonic vibration energy to the ultrasonic blade; and a jaw member movable relative to the ultrasonic blade from a spaced-apart position to an approximated position for clamping tissue therebetween, wherein the jaw member includes: a structural body; and a jaw liner engaged with the structural body, the jaw liner defining a tissue contacting surface positioned to oppose the ultrasonic blade in the approximated position and characterised by the jaw liner including a wear indicator configured to send an alert indicating that the jaw liner is worn beyond a pre-determined threshold. an ultrasonic blade mechanically coupled to an ultrasonic transducer configured to transmit ultrasonic vibration energy to the ultrasonic blade; and a jaw member movable relative to the ultrasonic blade from a spaced-apart position to an approximated position for clamping tissue therebetween, wherein the jaw member includes: a structural body; and a jaw liner engaged with the structural body, the jaw liner defining a tissue contacting surface positioned to oppose the ultrasonic blade in the approximated position and characterised by the jaw liner including a wear indicator configured to send an alert indicating that the jaw liner is worn beyond a pre-determined threshold. a structural body; and a jaw liner engaged with the structural body, the jaw liner defining a tissue contacting surface positioned to oppose the ultrasonic blade in the approximated position and characterised by the jaw liner including a wear indicator configured to send an alert indicating that the jaw liner is worn beyond a pre-determined threshold.
A display device comprising: a first substrate comprising a display area comprising a pixel area and a non-display area adjacent to the display area, the first substrate comprising a connection pad in the non-display area; and a second substrate facing the first substrate, the second substrate comprising a base substrate comprising a sensing area corresponding to the display area and a non-sensing area corresponding to the non-display area, and a touch sensor on the base substrate, wherein the touch sensor comprises a touch sensing electrode in the sensing area, a touch pad in the non-sensing area, and a sensing line electrically connecting the touch sensing electrode and the touch pad, and wherein the non-sensing area of the second substrate is bent characterized in that the first substrate is not bent such that the connection pad and the touch pad face each other, wherein the connection pad and the touch pad are electrically connected with each other, the display device further comprising an elastic member having adhesion, wherein the elastic member is disposed between areas of the second substrate, which face each other as the second substrate is bent, to maintain the bent shape of the second substrate. a first substrate comprising a display area comprising a pixel area and a non-display area adjacent to the display area, the first substrate comprising a connection pad in the non-display area; and a second substrate facing the first substrate, the second substrate comprising a base substrate comprising a sensing area corresponding to the display area and a non-sensing area corresponding to the non-display area, and a touch sensor on the base substrate, wherein the touch sensor comprises a touch sensing electrode in the sensing area, a touch pad in the non-sensing area, and a sensing line electrically connecting the touch sensing electrode and the touch pad, and wherein the non-sensing area of the second substrate is bent characterized in that the first substrate is not bent such that the connection pad and the touch pad face each other, wherein the connection pad and the touch pad are electrically connected with each other, the display device further comprising an elastic member having adhesion, wherein the elastic member is disposed between areas of the second substrate, which face each other as the second substrate is bent, to maintain the bent shape of the second substrate.