A minimally invasive electroporation device comprising: a voltage generator; and an array having a plurality of electrodes in electrical communication with the voltage generator, wherein: the electroporation device is capable of delivering to a subject an electrical potential to layers of epidermal tissue between stratum corneum and basal layers that results in electroporation of cells in the layers of epidermal tissue between stratum corneum and basal layers; each one of the plurality of electrodes are spaced apart from each adjacent electrode at a distance of about 0.5 mm to about 2.5 mm; the voltage generator delivers via the electrodes an electrical potential of about 0.01 volts to about 70 volts to the layers of epidermal tissue between stratum corneum and basal layers; and the electrodes have a tip on the distal end that is blunt with a sharp point allowing the electrode to penetrate the layers of epidermis tissue between stratum corneum and basal layers while preventing the penetration depth from exceeding 0.1 mm, said electrodes being adapted to deliver the electrical potential from the voltage generator to the layers of epidermis tissue between stratum corneum and basal layers.; a voltage generator; and an array having a plurality of electrodes in electrical communication with the voltage generator, wherein: the electroporation device is capable of delivering to a subject an electrical potential to layers of epidermal tissue between stratum corneum and basal layers that results in electroporation of cells in the layers of epidermal tissue between stratum corneum and basal layers; each one of the plurality of electrodes are spaced apart from each adjacent electrode at a distance of about 0.5 mm to about 2.5 mm; the voltage generator delivers via the electrodes an electrical potential of about 0.01 volts to about 70 volts to the layers of epidermal tissue between stratum corneum and basal layers; and the electrodes have a tip on the distal end that is blunt with a sharp point allowing the electrode to penetrate the layers of epidermis tissue between stratum corneum and basal layers while preventing the penetration depth from exceeding 0.1 mm, said electrodes being adapted to deliver the electrical potential from the voltage generator to the layers of epidermis tissue between stratum corneum and basal layers.; the electroporation device is capable of delivering to a subject an electrical potential to layers of epidermal tissue between stratum corneum and basal layers that results in electroporation of cells in the layers of epidermal tissue between stratum corneum and basal layers; each one of the plurality of electrodes are spaced apart from each adjacent electrode at a distance of about 0.5 mm to about 2.5 mm; the voltage generator delivers via the electrodes an electrical potential of about 0.01 volts to about 70 volts to the layers of epidermal tissue between stratum corneum and basal layers; and the electrodes have a tip on the distal end that is blunt with a sharp point allowing the electrode to penetrate the layers of epidermis tissue between stratum corneum and basal layers while preventing the penetration depth from exceeding 0.1 mm, said electrodes being adapted to deliver the electrical potential from the voltage generator to the layers of epidermis tissue between stratum corneum and basal layers.;