A deuterium-enriched compound of formula I, formula II, or a stereoisomer or pharmaceutically acceptable salt thereof: i) where formula I is represented by: wherein: R 8 is selected from H and D; R 8a is -OR 12a one of X and Y is C=O and the other is selected from CH 2, CHD, CD 2, and C=O; Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 -R 7 are independently selected from H and D; R 12a is CH 2 -R a - R b - R c; R a is a bond, alternatively, R a is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, wherein R a is optionally substituted with 1-3 halogen; R b is selected from (CH 2) m, O(CH 2) m, and (CH 2) m O; m is selected from 0-3; R c is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, and R c is substituted with 0-2 groups selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, =O, NR 20 2, CO 2 R 20, -CN, OH, halogen, S 2 (C 1 -C 8) alkyl, aryl substituted with 0-2 R d, and (C 2 -C 9)heteroaryl substituted with 0-2 R d; R d is selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, halogen, CONR 20 2, CO 2 (C 1 -C 6)alkyl, and CO 2 (C 1 -C 6)haloalkyl; R 20 is selected from H and (C 1 -C 8 alkyl) wherein a hydrogen atom present in any of the substituents is optionally replaced by deuterium; and (ii) where formula II is represented by: wherein: Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 - R 7 and R 9 - R 10 are independently selected from H and D; R 8 is selected from H and D; R 11 is selected from H, D and CH 3; and R 12a - R 12e are independently selected from H and D. i) where formula I is represented by: wherein: R 8 is selected from H and D; R 8a is -OR 12a one of X and Y is C=O and the other is selected from CH 2, CHD, CD 2, and C=O; Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 -R 7 are independently selected from H and D; R 12a is CH 2 -R a - R b - R c; R a is a bond, alternatively, R a is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, wherein R a is optionally substituted with 1-3 halogen; R b is selected from (CH 2) m, O(CH 2) m, and (CH 2) m O; m is selected from 0-3; R c is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, and R c is substituted with 0-2 groups selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, =O, NR 20 2, CO 2 R 20, -CN, OH, halogen, S 2 (C 1 -C 8) alkyl, aryl substituted with 0-2 R d, and (C 2 -C 9)heteroaryl substituted with 0-2 R d; R d is selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, halogen, CONR 20 2, CO 2 (C 1 -C 6)alkyl, and CO 2 (C 1 -C 6)haloalkyl; R 20 is selected from H and (C 1 -C 8 alkyl) wherein a hydrogen atom present in any of the substituents is optionally replaced by deuterium; and R 8 is selected from H and D; R 8a is -OR 12a one of X and Y is C=O and the other is selected from CH 2, CHD, CD 2, and C=O; Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 -R 7 are independently selected from H and D; R 12a is CH 2 -R a - R b - R c; R a is a bond, alternatively, R a is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, wherein R a is optionally substituted with 1-3 halogen; R b is selected from (CH 2) m, O(CH 2) m, and (CH 2) m O; m is selected from 0-3; R c is selected from aryl, (C 1 -C 6)heterocycloalkyl, and (C 2 -C 9)heteroaryl, and R c is substituted with 0-2 groups selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, =O, NR 20 2, CO 2 R 20, -CN, OH, halogen, S 2 (C 1 -C 8) alkyl, aryl substituted with 0-2 R d, and (C 2 -C 9)heteroaryl substituted with 0-2 R d; R d is selected from (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)haloalkoxy, halogen, CONR 20 2, CO 2 (C 1 -C 6)alkyl, and CO 2 (C 1 -C 6)haloalkyl; R 20 is selected from H and (C 1 -C 8 alkyl) wherein a hydrogen atom present in any of the substituents is optionally replaced by deuterium; and (ii) where formula II is represented by: wherein: Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 - R 7 and R 9 - R 10 are independently selected from H and D; R 8 is selected from H and D; R 11 is selected from H, D and CH 3; and R 12a - R 12e are independently selected from H and D. Z is H or D, provided that the abundance of deuterium in Z is at least 30%; R 1 - R 7 and R 9 - R 10 are independently selected from H and D; R 8 is selected from H and D; R 11 is selected from H, D and CH 3; and R 12a - R 12e are independently selected from H and D.