mhurhangee/ep-ind-claims huggingface dataset:
A method for testing sensitivity of tumor cells to antineoplastic drugs, comprising the steps of: dissolving an antineoplastic drug in a cell culture fluid comprising the tumor cells, wherein the antineoplastic drug is comprised in a sterile and instantly dissolvable drug membrane, and wherein said membrane is fully dissolved in the cell culture fluid, and wherein the thickness of the sterile and instantly dissolvable drug membrane is 0.01 mm - 1 mm and the area thereof is 0.2 cm 2 -25 cm 2, and wherein 1 cm 2 of the sterile and instantly dissolvable drug membrane is dissolved in 1 ml of the cell culture fluid within 5 min, preferably within 3 min and more preferably within 100 sec, and assessing the inhibition rate of the drug on the tumor cells, wherein an inhibition rate > 50% means that the tumor cells are sensitive to the drug, and wherein said inhibition rate is defined as [(active cells of blank drug membrane control group - active cells of experimental group) / active cells of blank drug membrane control group] × 100%.
A bioprocess system comprising a rupture disk, a first component, and optionally a second component; wherein the first component comprises a bioprocessing unit and the optional second component is a reservoir, a vessel, a tank, or a pipe; characterised in that the rupture disk comprises: a body including an internal wall extending from a first end of the body to a second end of the body, the internal wall defining an opening extending through the body, the body further including an internal flange formed on the internal wall, the internal flange having a stepped surface; a rupture membrane positioned within the body having a first surface facing the first end of the body and a second surface facing the second end of the body, wherein the first surface is a clean surface configured for engaging a biological product during a biological process, and wherein the second surface of the rupture membrane is secured to the stepped surface to form a hermetic seal, the stepped surface and the rupture membrane being positioned within the body such that the rupture membrane does not extend beyond the first end of the body; and a metal-to-metal bond between a first metal of the internal flange and a second metal of the rupture membrane wherein the metal-to-metal bond joins the stepped surface of the internal flange and the rupture membrane surface of the rupture membrane; wherein the stepped surface of the internal flange and the second surface of the rupture membrane are joined together by a cold weld. a body including an internal wall extending from a first end of the body to a second end of the body, the internal wall defining an opening extending through the body, the body further including an internal flange formed on the internal wall, the internal flange having a stepped surface; a rupture membrane positioned within the body having a first surface facing the first end of the body and a second surface facing the second end of the body, wherein the first surface is a clean surface configured for engaging a biological product during a biological process, and wherein the second surface of the rupture membrane is secured to the stepped surface to form a hermetic seal, the stepped surface and the rupture membrane being positioned within the body such that the rupture membrane does not extend beyond the first end of the body; and a metal-to-metal bond between a first metal of the internal flange and a second metal of the rupture membrane wherein the metal-to-metal bond joins the stepped surface of the internal flange and the rupture membrane surface of the rupture membrane; wherein the stepped surface of the internal flange and the second surface of the rupture membrane are joined together by a cold weld.
A motor, comprising: a first rotatable member; an anchor, spaced apart from the first rotatable member; a belt, in tension about the first rotatable member and the anchor, the belt being co-rotatably engaged with the first rotatable member, wherein the belt is made from a shape-memory alloy; and a thermal regulation device, the motor being characterised in that the thermal regulation device is positioned between spaced-apart first and second portions (134, 136) of the belt, wherein the thermal regulation device comprises a first surface directly adjacent the first portion of the belt and the thermal regulation device comprises a second surface directly adjacent the second portion of the belt, and wherein the thermal regulation device is configured to concurrently cool the first portion of the belt to contract the first portion of the belt and heat the second portion of the belt to expand the second portion of the belt, wherein concurrent contraction and expansion of the first and second portions (134, 136) of the belt cause rotation of the belt. a first rotatable member; an anchor, spaced apart from the first rotatable member; a belt, in tension about the first rotatable member and the anchor, the belt being co-rotatably engaged with the first rotatable member, wherein the belt is made from a shape-memory alloy; and a thermal regulation device, the motor being characterised in that the thermal regulation device is positioned between spaced-apart first and second portions (134, 136) of the belt, wherein the thermal regulation device comprises a first surface directly adjacent the first portion of the belt and the thermal regulation device comprises a second surface directly adjacent the second portion of the belt, and wherein the thermal regulation device is configured to concurrently cool the first portion of the belt to contract the first portion of the belt and heat the second portion of the belt to expand the second portion of the belt, wherein concurrent contraction and expansion of the first and second portions (134, 136) of the belt cause rotation of the belt.
A method of crosslinking a paper based material selected from printing paper, gypsum grade paper, kraft sack paper, paperboard, liquid packaging board, corrugated board, fine paper, thin paper, and specialty paper, wherein the method comprises the steps of: a) preparing an aqueous crosslinking solution consisting of; - a crosslinking polysaccharide containing at least two carboxylic acid functionalities selected from pectines, carboxymethyl starch, carboxymethyl cellulose and mixtures thereof; and - an organic acid crosslinking catalyst selected from formic acid, acetic acid, propionic acid, butanoic acid, and pentanoic acid, mandelic acid, amino acid, maleic acid, tartaric acid, citric acid and mixtures thereof in the amount of 0.1-100 weight parts, calculated on 100 weight parts of said crosslinking polysaccharide, b) adding said aqueous crosslinking solution by coating, spraying on said paper based material or dipping said paper based material in said aqueous crosslinking solution and c) removing the water from said paper based material by heating at a temperature ranging from 50-200°C in between 1 minute to 8 hours. a) preparing an aqueous crosslinking solution consisting of; - a crosslinking polysaccharide containing at least two carboxylic acid functionalities selected from pectines, carboxymethyl starch, carboxymethyl cellulose and mixtures thereof; and - an organic acid crosslinking catalyst selected from formic acid, acetic acid, propionic acid, butanoic acid, and pentanoic acid, mandelic acid, amino acid, maleic acid, tartaric acid, citric acid and mixtures thereof in the amount of 0.1-100 weight parts, calculated on 100 weight parts of said crosslinking polysaccharide, - a crosslinking polysaccharide containing at least two carboxylic acid functionalities selected from pectines, carboxymethyl starch, carboxymethyl cellulose and mixtures thereof; and - an organic acid crosslinking catalyst selected from formic acid, acetic acid, propionic acid, butanoic acid, and pentanoic acid, mandelic acid, amino acid, maleic acid, tartaric acid, citric acid and mixtures thereof in the amount of 0.1-100 weight parts, calculated on 100 weight parts of said crosslinking polysaccharide, b) adding said aqueous crosslinking solution by coating, spraying on said paper based material or dipping said paper based material in said aqueous crosslinking solution and c) removing the water from said paper based material by heating at a temperature ranging from 50-200°C in between 1 minute to 8 hours.
An engine cooling device comprising: a water pump that controls a flow rate of cooling water for cooling an engine; a radiator; a first cooling water channel that passes the cooling water to the engine through the radiator; a second cooling water channel that passes the cooling water to the engine without going through the radiator; a solenoid valve provided in the second cooling water channel, the solenoid valve including a valve body, the valve body being moved by electric suction force to open and close the solenoid valve; and a control unit configured to execute control, at a time of closing the solenoid valve in the second cooling water channel, to close the solenoid valve so as to cut off passage of the cooling water in the second cooling water channel by moving the valve body in a valve closing direction with at least electric suction force while the cooling water is passing at a decreased flow rate, the decreased flow rate being achieved by driving the water pump so as to decrease the flow rate of the cooling water, characterised in that the control unit is configured to execute control to close the solenoid valve in the second cooling water channel by acquiring a valve-closable maximum speed of the water pump based on at least flow resistance of the cooling water and by moving the valve body while the water pump is driven at a speed equal to or less than the valve-closable maximum speed. a water pump that controls a flow rate of cooling water for cooling an engine; a radiator; a first cooling water channel that passes the cooling water to the engine through the radiator; a second cooling water channel that passes the cooling water to the engine without going through the radiator; a solenoid valve provided in the second cooling water channel, the solenoid valve including a valve body, the valve body being moved by electric suction force to open and close the solenoid valve; and a control unit configured to execute control, at a time of closing the solenoid valve in the second cooling water channel, to close the solenoid valve so as to cut off passage of the cooling water in the second cooling water channel by moving the valve body in a valve closing direction with at least electric suction force while the cooling water is passing at a decreased flow rate, the decreased flow rate being achieved by driving the water pump so as to decrease the flow rate of the cooling water, characterised in that the control unit is configured to execute control to close the solenoid valve in the second cooling water channel by acquiring a valve-closable maximum speed of the water pump based on at least flow resistance of the cooling water and by moving the valve body while the water pump is driven at a speed equal to or less than the valve-closable maximum speed.
An imaging system comprising: a registration component configured to register a first image of a region of interest, representing a first time, to a second image of a region of interest, representing a second time; a difference component configured to generate a difference image from the first image and the second image; and a pattern recognition component configured to assign a clinical parameter to each of a plurality of subregions within the region of interest for each of the difference image and at least one of the first image and the second image using a windowing approach in which each subregion of the image is analyzed individually according to at least one stored rule set and assign a global clinical parameter to the region of interest from the clinical parameters assigned to the plurality of subregions of each of the difference image and at least one of the first image and the second image. a registration component configured to register a first image of a region of interest, representing a first time, to a second image of a region of interest, representing a second time; a difference component configured to generate a difference image from the first image and the second image; and a pattern recognition component configured to assign a clinical parameter to each of a plurality of subregions within the region of interest for each of the difference image and at least one of the first image and the second image using a windowing approach in which each subregion of the image is analyzed individually according to at least one stored rule set and assign a global clinical parameter to the region of interest from the clinical parameters assigned to the plurality of subregions of each of the difference image and at least one of the first image and the second image.
An isolated cell in which expression of a T-cell receptor gene is modulated by modification within exon c2 of the T-cell receptor alpha (TCRA) gene, wherein the modification is an insertion and/or deletion within TTGAAA of exon c2 of the TCRA gene, and wherein the isolated cell comprises a pair of zinc finger nucleases (ZFNs) that cleave the TCRA gene, the pair of ZFNs comprising first and second ZFNs, wherein the first ZFN comprises a first cleavage domain or cleavage half-domain, and a zinc finger protein comprising six zinc fingers designated and ordered F1 to F6, each zinc finger comprising a recognition helix region as follows: F1: QSSDLSR (SEQ ID NO:57); F2: QSGNRTT (SEQ ID NO:58); F3: RSANLAR (SEQ ID NO:59); F4: DRSALAR (SEQ ID NO:33); F5: RSDVLSE (SEQ ID NO:60); and F6: KHSTRRV (SEQ ID NO:61); and the second ZFN comprises a second cleavage domain or cleavage half-domain, and a ZFP comprising six zinc fingers designated and ordered F1 to F6, each zinc finger comprising a recognition helix region as follows: F1: TMHQRVE (SEQ ID NO:62); F2: TSGHLSR (SEQ ID NO:63); F3: RSDHLTQ (SEQ ID NO:64); F4: DSANLSR (SEQ ID NO:65); F5: QSGSLTR (SEQ ID NO:66); and F6: AKWNLDA (SEQ ID NO:67) and further wherein the insertion and/or deletion in the TRAC gene is made by the pair of ZFNs and expression of TRAC gene is modulated by the insertion and/or deletion. F1: QSSDLSR (SEQ ID NO:57); F2: QSGNRTT (SEQ ID NO:58); F3: RSANLAR (SEQ ID NO:59); F4: DRSALAR (SEQ ID NO:33); F5: RSDVLSE (SEQ ID NO:60); and F6: KHSTRRV (SEQ ID NO:61); and the second ZFN comprises a second cleavage domain or cleavage half-domain, and a ZFP comprising six zinc fingers designated and ordered F1 to F6, each zinc finger comprising a recognition helix region as follows: F1: TMHQRVE (SEQ ID NO:62); F2: TSGHLSR (SEQ ID NO:63); F3: RSDHLTQ (SEQ ID NO:64); F4: DSANLSR (SEQ ID NO:65); F5: QSGSLTR (SEQ ID NO:66); and F6: AKWNLDA (SEQ ID NO:67) F1: TMHQRVE (SEQ ID NO:62); F2: TSGHLSR (SEQ ID NO:63); F3: RSDHLTQ (SEQ ID NO:64); F4: DSANLSR (SEQ ID NO:65); F5: QSGSLTR (SEQ ID NO:66); and F6: AKWNLDA (SEQ ID NO:67)
Electrical plug socket having a housing which comprises a plug compartment for the insertion of a connection plug, wherein arranged in the housing is a contact module having a pressed multi-layer circuit board arrangement (26, 76), fixed to which are contact elements that are contactable by associated plug contacts of the connection plug, and wherein the pressed multi-layer circuit board arrangement (26, 76) comprises a dielectric stabilization layer (32, 82) and arranged above and/or below the stabilization layer (32, 82) is a layer arrangement (38, 40, 88, 90) having a dielectric carrier layer (42, 58, 92, 104) which is positioned between an outer conductor track layer (46, 62, 96, 108) and an inner conductor track layer (54, 70, 98, 112), wherein the layer arrangement (38, 40, 88, 90) forms at least one plate capacitor (73, 74, 103, 118), characterized in that the carrier layer (42, 58, 92, 104) of the layer arrangement (38, 40, 88, 90) comprises a fiber-reinforced resin that has already been cured before the pressing of the multi-layer circuit board arrangement (26, 76) and arranged between the layer arrangement (38, 40, 88, 90) and the stabilization layer (32, 82) is at least one prepreg layer (50, 66, 102, 116) for fixing the layer arrangement (38, 40, 88, 90) to the stabilization layer (32, 82).
A valve device constituting a part of an airflow passage of a fuel tank, and including a float constituting a lower valve body, and a case accommodating the float, wherein the valve device further comprises: a top portion of the case formed with a first penetration hole, and an upper valve body, characterized in that a cylindrical seal body with a part that is fit in the first penetration hole and is sandwiched between the top portion and a sandwich member having a second penetration hole and combined with the top portion from above the top portion, an inside of the cylindrical seal body communicating with the second penetration hole of the sandwich member, and the upper valve body is located above the sandwich member and configured to open and close the second penetration hole. a top portion of the case formed with a first penetration hole, and an upper valve body, characterized in that a cylindrical seal body with a part that is fit in the first penetration hole and is sandwiched between the top portion and a sandwich member having a second penetration hole and combined with the top portion from above the top portion, an inside of the cylindrical seal body communicating with the second penetration hole of the sandwich member, and the upper valve body is located above the sandwich member and configured to open and close the second penetration hole.
A heat exchanger, comprising - at least one electrical resistance heating element, in particular at least one PTC element, - at least two flat conductors which are connected to the at least one electrical resistance heating element in an electrically conductive manner, in particular conductor plates (6, 7), wherein the conductors are arranged on both sides of the resistance heating elements in order to guide electric current through the at least one electrical resistance heating element and thereby heat the electrical resistance heating element, - at least one heat-conducting element for the transfer of heat from the at least one electrical resistance heating element to a fluid to be heated, - at least one electrically insulating element which electrically insulates the at least two conductors, preferably from the at least one heat-conducting element, wherein - the at least two conductors and the at least one electrical resistance heating element are arranged in at least one hollow space limited by at least one wall of the hollow space and the at least one electrically insulating element is at least one moulded seal, wherein the at least one wall of the hollow space is formed as at least one closed flat tube, characterised in that the closed flat tube is formed without a joint in the cross section and the at least one moulded seal in the hollow space is formed as a hose, in particular a shrinking hose. - at least one electrical resistance heating element, in particular at least one PTC element, - at least two flat conductors which are connected to the at least one electrical resistance heating element in an electrically conductive manner, in particular conductor plates (6, 7), wherein the conductors are arranged on both sides of the resistance heating elements in order to guide electric current through the at least one electrical resistance heating element and thereby heat the electrical resistance heating element, - at least one heat-conducting element for the transfer of heat from the at least one electrical resistance heating element to a fluid to be heated, - at least one electrically insulating element which electrically insulates the at least two conductors, preferably from the at least one heat-conducting element, wherein - the at least two conductors and the at least one electrical resistance heating element are arranged in at least one hollow space limited by at least one wall of the hollow space and the at least one electrically insulating element is at least one moulded seal, wherein
Rotating projector for a coating product comprising - a spraying device of the coating product having at least one circular spraying edge, - means for driving the spraying device around a rotational axis (X 30), - a body that defines the rotational axis and which comprises primary openings arranged on a primary contour (C 30) surrounding the rotational axis, with each primary opening intended for injecting a primary air jet (J 34) in a primary direction (Δ 34) having, with respect to the rotational axis, an axial component (A 34) and an orthoradial component (O 34) which are not equal to zero, the primary direction (Δ 34) having a radial component (R 34) which is not equal to zero and centrifugal with respect to the rotational axis (X 30) and a primary jet (J 34) extending, at the spraying edge along the rotational axis, at a distance (d 34) from the rotational axis (X 30) that is strictly greater than the radius (R 20) of the spraying edge, characterised in that: - the body comprises secondary openings arranged on a secondary contour (C 30) surrounding the rotational axis (X 30), each secondary opening being intended for ejecting a secondary air jet (J 36) in a secondary direction (Δ 36) having, with respect to the rotational axis, an axial component (A 36) and a centripetal radial component (R 36) which are not equal to zero, such that the secondary jet hits an external surface of the spraying device, - the primary and secondary contours of the primary and secondary openings coincide with a circle (C 30) centred about the rotational axis (X 30), and - the primary direction (Δ 34) forms, in a radial plane and with respect to the rotational axis (X 30), an angle (α) between 3 and 12°. - a spraying device of the coating product having at least one circular spraying edge, - means for driving the spraying device around a rotational axis (X 30), - a body that defines the rotational axis and which comprises primary openings arranged on a primary contour (C 30) surrounding the rotational axis, - the body comprises secondary openings arranged on a secondary contour (C 30) surrounding the rotational axis (X 30), each secondary opening being intended for ejecting a secondary air jet (J 36) in a secondary direction (Δ 36) having, with respect to the rotational axis, an axial component (A 36) and a centripetal radial component (R 36) which are not equal to zero, such that the secondary jet hits an external surface of the spraying device, - the primary and secondary contours of the primary and secondary openings coincide with a circle (C 30) centred about the rotational axis (X 30), and - the primary direction (Δ 34) forms, in a radial plane and with respect to the rotational axis (X 30), an angle (α) between 3 and 12°.
A hygiene article comprising an odour control composition for urine, menses, including blood and blood components, vaginal secretions and sweat, the hygiene article comprising a liquid permeable topsheet, a liquid impermeable backsheet and a liquid absorbent core disposed between said liquid permeable topsheet and said liquid impermeable backsheet, said odour control composition comprising an organic zinc salt, characterized in that said odour control composition comprises an anti-microbial agent selected from the group comprising essential oils and/or active components of essential oils, said anti-microbial agent comprising essential oil of thyme or thymol.