An infusion system comprising: a sensing arrangement to obtain measurement values for a physiological condition from a body of a user; an infusion device including: an actuation arrangement operable to deliver fluid influencing the physiological condition to the body of the user; a user interface; and a control system coupled to the actuation arrangement and the sensing arrangement to: autonomously operate the actuation arrangement to deliver the fluid based on the measurement values; obtain one or more reference measurements (802, 902) of the physiological condition in the body of the user; determine a lag (808, 906) associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the measurement values; automatically identify a current site location (806, 908) on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag; determine one or more performance metrics (814, 914) associated with the current site location based on the measurement values; and provide a sensor site rotation recommendation via the user interface in a manner that is influenced by the one or more performance metrics. a sensing arrangement to obtain measurement values for a physiological condition from a body of a user; an infusion device including: an actuation arrangement operable to deliver fluid influencing the physiological condition to the body of the user; a user interface; and a control system coupled to the actuation arrangement and the sensing arrangement to: autonomously operate the actuation arrangement to deliver the fluid based on the measurement values; obtain one or more reference measurements (802, 902) of the physiological condition in the body of the user; determine a lag (808, 906) associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the measurement values; automatically identify a current site location (806, 908) on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag; determine one or more performance metrics (814, 914) associated with the current site location based on the measurement values; and provide a sensor site rotation recommendation via the user interface in a manner that is influenced by the one or more performance metrics. an actuation arrangement operable to deliver fluid influencing the physiological condition to the body of the user; a user interface; and a control system coupled to the actuation arrangement and the sensing arrangement to: autonomously operate the actuation arrangement to deliver the fluid based on the measurement values; obtain one or more reference measurements (802, 902) of the physiological condition in the body of the user; determine a lag (808, 906) associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the measurement values; automatically identify a current site location (806, 908) on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag; determine one or more performance metrics (814, 914) associated with the current site location based on the measurement values; and provide a sensor site rotation recommendation via the user interface in a manner that is influenced by the one or more performance metrics. autonomously operate the actuation arrangement to deliver the fluid based on the measurement values; obtain one or more reference measurements (802, 902) of the physiological condition in the body of the user; determine a lag (808, 906) associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the measurement values; automatically identify a current site location (806, 908) on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag; determine one or more performance metrics (814, 914) associated with the current site location based on the measurement values; and provide a sensor site rotation recommendation via the user interface in a manner that is influenced by the one or more performance metrics.