mhurhangee/ep-ind-claims huggingface dataset:
A compound having the following formula I: wherein: R 1 is hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl; R 2 is C 5-8 aryl or C 5-8 heteroaryl, substituted with 0-4 R 2a; R 2a is independently, at each occurrence, hydrogen, C 1-6 alkyl, C 1-6 alkoxy, -S 2 R 2b, C NR 2c R 2d or a 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S substituted with 0-2 R b; R 2b is hydrogen or C 1-4 alkyl; R 2c is hydrogen or C 1-4 alkyl; R 2d is hydrogen or C 1-4 alkyl; R b is hydrogen or C 1-4 alkyl; R 3 is C -C 3-10 cycloalkyl, C 6-10 aryl or a 5-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, each group substituted with 0-4 R 3a; R 3a is independently, at each occurrence, hydrogen, halo, OH, OCF 3, CF 3, CHF 2, CN, C 1-6 alkyl, C 1-6 alkoxy, -C NR 3b R 3c, 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S, or C - 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S; R 3b is hydrogen or C 1-4 alkyl; R 3c is hydrogen or C 1-4 alkyl; or a stereoisomer or pharmaceutically-acceptable salt thereof. R 1 is hydrogen, C 1-6 alkyl or C 3-8 cycloalkyl; R 2 is C 5-8 aryl or C 5-8 heteroaryl, substituted with 0-4 R 2a; R 2a is independently, at each occurrence, hydrogen, C 1-6 alkyl, C 1-6 alkoxy, -S 2 R 2b, C NR 2c R 2d or a 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S substituted with 0-2 R b; R 2b is hydrogen or C 1-4 alkyl; R 2c is hydrogen or C 1-4 alkyl; R 2d is hydrogen or C 1-4 alkyl; R b is hydrogen or C 1-4 alkyl; R 3 is C -C 3-10 cycloalkyl, C 6-10 aryl or a 5-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, each group substituted with 0-4 R 3a; R 3a is independently, at each occurrence, hydrogen, halo, OH, OCF 3, CF 3, CHF 2, CN, C 1-6 alkyl, C 1-6 alkoxy, -C NR 3b R 3c, 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S, or C - 5-7 membered heterocycle containing 1-4 heteroatoms selected from N, O, and S; R 3b is hydrogen or C 1-4 alkyl; R 3c is hydrogen or C 1-4 alkyl; or a stereoisomer or pharmaceutically-acceptable salt thereof.
Tray sealing machine comprising a sealing tool lower part and a gripper system for transporting n trays, wherein the sealing tool lower part comprises n vertically moveable support plates and a tray receptacle with n openings for one tray each, characterized in that each support plate comprises a checking device for detecting a misalignment of the tray on the respective support plate.
A tissue closure device (12, 2212, 1800) comprising: a compressible body comprising a pair of parallel legs having two opposed compliant tissue-engaging surfaces (36, 38), wherein the legs (32, 24) are each comprised of a soft biologically compatible polymer that provides a three-dimensional compliance so the tissue-engaging surfaces (36, 38) conform to a three-dimensional topography of tissue upon compression; and a plurality of tissue-penetrating fasteners (50, 54; 1824, 1834) spaced-apart along the legs and disposed to extend from a first one of the tissue-engaging surfaces, through the tissue at a puncture site, to a second one of the tissue-engaging surface to close the tissue there between, characterised in that the tissue-penetrating fasteners comprise male and female fasteners (50, 54; 1824, 1834) a compressible body comprising a pair of parallel legs having two opposed compliant tissue-engaging surfaces (36, 38), wherein the legs (32, 24) are each comprised of a soft biologically compatible polymer that provides a three-dimensional compliance so the tissue-engaging surfaces (36, 38) conform to a three-dimensional topography of tissue upon compression; and a plurality of tissue-penetrating fasteners (50, 54; 1824, 1834) spaced-apart along the legs and disposed to extend from a first one of the tissue-engaging surfaces, through the tissue at a puncture site, to a second one of the tissue-engaging surface to close the tissue there between, characterised in that the tissue-penetrating fasteners comprise male and female fasteners (50, 54; 1824, 1834)
A method, executed by a mobile terminal, for signaling capability information in a wireless communication network, the method comprising sending a band capability information element to a network node in the wireless communication network, the band capability information element indicating one or more frequency band combinations supported by the mobile terminal for carrier aggregation, the method further comprising: sending additional information corresponding to at least one of the frequency band combinations, the additional information indicating limited support for the at least one frequency band combination, relative to a predetermined full level of support for frequency band combinations where no combination of resource allocations across the indicated frequency bands cause any desensitization or other performance degradation at a receiver of the terminal, wherein the additional information indicates a performance reduction amount, relative to a predetermined performance level, for at least one of the frequency band combinations, the performance reduction amount indicating a level of perceived mobile terminal receiver desensitization in dB. sending additional information corresponding to at least one of the frequency band combinations, the additional information indicating limited support for the at least one frequency band combination, relative to a predetermined full level of support for frequency band combinations where no combination of resource allocations across the indicated frequency bands cause any desensitization or other performance degradation at a receiver of the terminal, wherein the additional information indicates a performance reduction amount, relative to a predetermined performance level, for at least one of the frequency band combinations, the performance reduction amount indicating a level of perceived mobile terminal receiver desensitization in dB.
A tabletop napkin dispenser including a front member and an open ended housing defining an interior space for housing a stack of napkins, wherein the front member includes a dispensing opening, and wherein the front member is moveable from an open position for providing access to refill napkins in the interior space and a closed position to close the open end of the housing; wherein the front member is provided by a lid member pivotably connected to the open ended housing that is rotatable about the pivot (91, 92) between the closed and open positions, characterised in that: the front member includes at least one tab and the housing includes a through opening into which a projection of the tab resiliently snaps to hold the front member in the closed position, wherein the projection can be pushed on from outside of the napkin dispenser and moved through the opening to resiliently deflect the tab interiorly to disengage the projection and the opening to allow the front member to be opened with respect to the housing, the napkin dispenser includes a stop member obstructing a path of inward deflection of the tab to define a stop position for limiting inward deflection of the tab, the tab member is attached at one end to the front member and includes an arm portion freely projecting from the attached end, wherein a projection portion at a distal end of the arm defines the projection for engaging the opening. the front member includes at least one tab and the housing includes a through opening into which a projection of the tab resiliently snaps to hold the front member in the closed position, wherein the projection can be pushed on from outside of the napkin dispenser and moved through the opening to resiliently deflect the tab interiorly to disengage the projection and the opening to allow the front member to be opened with respect to the housing, the napkin dispenser includes a stop member obstructing a path of inward deflection of the tab to define a stop position for limiting inward deflection of the tab, the tab member is attached at one end to the front member and includes an arm portion freely projecting from the attached end, wherein a projection portion at a distal end of the arm defines the projection for engaging the opening.
A computer implemented method for monitoring processor characteristic information of a processor (106, 106a) using run-time-instrumentation, wherein the monitoring characteristic information comprises processor speed, processor version, and model-dependent limits of the processor, characterised by the method comprising: executing an instruction stream on a processor; detecting a run-time instrumentation sample point of the executing instruction stream on the processor; and storing a unit of information in a run-time instrumentation program buffer based on the run-time instrumentation sample point, the unit of information including processor characteristic information associated with the processor. executing an instruction stream on a processor; detecting a run-time instrumentation sample point of the executing instruction stream on the processor; and storing a unit of information in a run-time instrumentation program buffer based on the run-time instrumentation sample point, the unit of information including processor characteristic information associated with the processor.
Window handle fitting with a window gear installed in a window part, the gear comprising a gear element, in particular a gear nut rotatable around an axial direction for opening and closing a window, with a latch element and with a moment transmission element, in particular a square element which is detachably connected with the gear element in an installed state of the window handle fitting to transmit a pivoting motion of the lash element in a rotation of the gear element around the axial direction, and wherein in the installed state the latch element is put on the moment transmission element and connected thereto in a detachable manner secured against loss, characterized in that the moment transmission element is attached in the installed state in a positive fit and in axial direction engaging at the rear with respect to the gear element in such a manner that the latch element is detachable from the moment transmission element without having to detach the positive fit engagement at the rear of the moment transmission element with the gear element, wherein the positive fit engagement at the rear in axial direction of the moment transmission element comprises a screw extending in the installed state in axial direction through the moment transmission element and being screwed into a counterpart on the side of the window gear.
A peptide consisting of the sequence: wherein Xaa 1 at position 22 is Nal or Phe; Xaa 2 at position 43 is Cys or absent; Xaa 3 at position 44 is Cys or absent; the C-terminal amino acid is optionally amidated; and provided that where Xaa 2 at position 43 or Xaa 3 at position 44 is Cys, then either or both are optionally PEGylated.
A device for hemostasis of a puncture site in a body lumen or tract, the device comprising: a catheter body having a proximal end and a distal end, and at least one axial lumen therethrough; an expansible member capable of being radially expanded and contracted on the distal end of the body; an external clip characterized in that it further comprises a helical coil spring having a central passage which receives the catheter body and having a distal end fixedly attached to the distal end of the catheter body and a proximal end connected to a tubular grip element slidable over the catheter body to allow the user to pull proximally on the coil spring to tension the expansible member against the puncture site, wherein the coil spring is long enough to extend outside the puncture site so that the coil spring may be adequately pulled via the grip element to achieve hemostasis; an axial member slidably disposed in the axial lumen of the catheter body to selectively radially expand and contract the expansible member, wherein the axial member has a distal end connected to a distal end of the expansible member, the expansible member having a proximal end connected to the distal end of the catheter body; and the external clip being coupleable to an exposed portion of the coil spring to engage a skin surface in order to hold the expansible member in tension against the puncture site. a catheter body having a proximal end and a distal end, and at least one axial lumen therethrough; an expansible member capable of being radially expanded and contracted on the distal end of the body; an external clip characterized in that it further comprises a helical coil spring having a central passage which receives the catheter body and having a distal end fixedly attached to the distal end of the catheter body and a proximal end connected to a tubular grip element slidable over the catheter body to allow the user to pull proximally on the coil spring to tension the expansible member against the puncture site, wherein the coil spring is long enough to extend outside the puncture site so that the coil spring may be adequately pulled via the grip element to achieve hemostasis; an axial member slidably disposed in the axial lumen of the catheter body to selectively radially expand and contract the expansible member, wherein the axial member has a distal end connected to a distal end of the expansible member, the expansible member having a proximal end connected to the distal end of the catheter body; and the external clip being coupleable to an exposed portion of the coil spring to engage a skin surface in order to hold the expansible member in tension against the puncture site.
A method for increasing the tactile feel of a glass-ceramic article, the method comprising: performing a first etching of a surface of the glass-ceramic article with a first etchant to create a plurality of features on the surface, wherein: the first etchant comprises hydrofluoric acid and an inorganic fluoride salt, and the plurality of features comprises protrusions and recesses; and performing a second etching of the surface with a second etchant different from the first etchant to polish the plurality of features and enlarge a distance between adjacent features of a same type, wherein: the second etching occurs after the first etching, and after the second etching an average distance between adjacent features of a same type is in a range from 0.5 μm to 25 μm and a density of features of the same type is in a range from 9,000 to 25,000 features/mm 2. performing a first etching of a surface of the glass-ceramic article with a first etchant to create a plurality of features on the surface, wherein: the first etchant comprises hydrofluoric acid and an inorganic fluoride salt, and the plurality of features comprises protrusions and recesses; and the first etchant comprises hydrofluoric acid and an inorganic fluoride salt, and the plurality of features comprises protrusions and recesses; and performing a second etching of the surface with a second etchant different from the first etchant to polish the plurality of features and enlarge a distance between adjacent features of a same type, wherein: the second etching occurs after the first etching, and after the second etching an average distance between adjacent features of a same type is in a range from 0.5 μm to 25 μm and a density of features of the same type is in a range from 9,000 to 25,000 features/mm 2. the second etching occurs after the first etching, and after the second etching an average distance between adjacent features of a same type is in a range from 0.5 μm to 25 μm and a density of features of the same type is in a range from 9,000 to 25,000 features/mm 2.
An electric tool comprising a motor comprising an output shaft, a housing that accommodates the motor, an operational member for turning on and turning off a drive switch of the motor, and a brake device including a brake plate fixed to the output shaft of the motor, a brake member capable of performing an operation of moving toward and away from the brake plate, and an urging unit that urges the brake member toward an abutment position where the brake member abuts on the brake plate, wherein the brake member is held in the housing, and the operational member is provided with a press member adapted to come into abutment on the brake member through an operation of turning on the drive switch of the motor, characterized in that the brake member is adapted to perform the operation of moving toward and away from the brake plate (3 1) by being rotated, and the press member is adapted to rotate the brake member in a rotational direction to move the brake member away from the brake plate against urging of the urging unit when coming into abutment with the brake member through the operation of turning on the drive switch.
A packaged prosthetic heart valve, the packaged prosthetic heart valve comprising: a prosthetic heart valve; and a container (102, 202, 302, 402, 502, 602, 702, 802, 902, 1002, 1102, 1202, 1302) including a first compartment (104, 204, 304, 403) housing the prosthetic heart valve and a second compartment (114, 214, 314, 414) housing a hydrogel (116, 216, 316, 416); wherein a semi-permeable membrane (112, 212, 312, 412 permeable to gas and/or moisture separates the first and second compartments (104, 114). a prosthetic heart valve; and a container (102, 202, 302, 402, 502, 602, 702, 802, 902, 1002, 1102, 1202, 1302) including a first compartment (104, 204, 304, 403) housing the prosthetic heart valve and a second compartment (114, 214, 314, 414) housing a hydrogel (116, 216, 316, 416); wherein a semi-permeable membrane (112, 212, 312, 412 permeable to gas and/or moisture separates the first and second compartments (104, 114).
An information processing device comprising: an action possibility analysis unit configured to acquire data of a three-dimensional shape of an environment surrounding a user by obtaining depth data from at least one depth sensor, and to analyze a body motion that a user may perform by considering physical limitations in the environment; an action execution feasibility database in which execution feasibilities of user body motions are recorded for individual three-dimensional environment shapes; and a picture generation unit configured to use an analysis result of the action possibility analysis unit to generate a picture according to the body motion the user may perform to be projected onto the environment by at least one projector, wherein the action possibility analysis unit is configured to analyze a body motion that the user may perform in the environment at a predetermined position in the environment by deciding the feasibility of the body motion of the user with respect to the data of the three-dimensional shape in a predetermined range including the predetermined position by cross-referencing, using machine learning or a probabilistic algorithm, the data of the three-dimensional shape and the data stored in the action execution feasibility database. an action possibility analysis unit configured to acquire data of a three-dimensional shape of an environment surrounding a user by obtaining depth data from at least one depth sensor, and to analyze a body motion that a user may perform by considering physical limitations in the environment; an action execution feasibility database in which execution feasibilities of user body motions are recorded for individual three-dimensional environment shapes; and a picture generation unit configured to use an analysis result of the action possibility analysis unit to generate a picture according to the body motion the user may perform to be projected onto the environment by at least one projector, wherein the action possibility analysis unit is configured to analyze a body motion that the user may perform in the environment at a predetermined position in the environment by deciding the feasibility of the body motion of the user with respect to the data of the three-dimensional shape in a predetermined range including the predetermined position by cross-referencing, using machine learning or a probabilistic algorithm, the data of the three-dimensional shape and the data stored in the action execution feasibility database.
A gyratory crusher comprising a frame and a crushing head, which is arranged rotatably about a substantially vertical shaft, the frame comprising an upper frame portion, and a lower frame portion, which lower frame portion comprises a hub, which hub comprises a centrally arranged through hole with a centre axis extending through said hole and the hub, which hole is arranged to cooperate with the shaft being turnably arranged in said hole, which hub is connected by arms to the lower frame portion and comprises a drive ring pocket bounded by a radially inner wall element, a radially outer wall element and a bottom wall element; characterised in that: the hub comprises a waist portion separated from the drive ring pocket by a thickness of the bottom wall element in a direction of the centre axis that is larger than a radial thickness of the inner wall element; and the waist portion comprises a thickness in a radial direction from the centre axis being larger than the width of the drive ring pocket. the hub comprises a waist portion separated from the drive ring pocket by a thickness of the bottom wall element in a direction of the centre axis that is larger than a radial thickness of the inner wall element; and the waist portion comprises a thickness in a radial direction from the centre axis being larger than the width of the drive ring pocket.
A surgical bur for removing or excising tissue from a surgical site, said surgical bur including: an elongated shaft lying along a longitudinal axis A and having opposed proximal and distal ends (24, 26), the proximal end of the shaft shaped for coupling to a surgical tool capable of rotating the shaft; a bur head (32, 92, 112, 132) attached to the distal end of the shaft, the bur head having a plurality of flutes (46, 94, 114, 134), each flute having: a rake surface (45, 116, 137) that extends outwardly from a center of the bur head and that has an outer end that defines a flute cutting edge (38, 148); and a cam surface (60, 118, 154) that extends arcuately away from the flute cutting edge to an adjacent flute; wherein at least one flute (46, 94, 114, 134) is further formed to have at least one rib (70, 96, 102, 124, 170, 172), said at least one rib extending arcuately over a portion of the cam surface and, relative to the longitudinal axis A, projecting radially outwardly from the cam surface, wherein the rib does not extend over the whole of the cam surface, characterized in that the bur head (32, 92, 112, 132) has a diameter that varies along the length of the bur head (32, 92, 112, 132); and said at least one flute is formed so that said rib (70, 124, 170, 172) extends outwardly from the cam surface at a location wherein the bur head has a maximum diameter. an elongated shaft lying along a longitudinal axis A and having opposed proximal and distal ends (24, 26), the proximal end of the shaft shaped for coupling to a surgical tool capable of rotating the shaft; a bur head (32, 92, 112, 132) attached to the distal end of the shaft, the bur head having a plurality of flutes (46, 94, 114, 134), each flute having: a rake surface (45, 116, 137) that extends outwardly from a center of the bur head and that has an outer end that defines a flute cutting edge (38, 148); and a cam surface (60, 118, 154) that extends arcuately away from the flute cutting edge to an adjacent flute; wherein at least one flute (46, 94, 114, 134) is further formed to have at least one rib (70, 96, 102, 124, 170, 172), said at least one rib extending arcuately over a portion of the cam surface and, relative to the longitudinal axis A, projecting radially outwardly from the cam surface, wherein the rib does not extend over the whole of the cam surface, characterized in that the bur head (32, 92, 112, 132) has a diameter that varies along the length of the bur head (32, 92, 112, 132); and said at least one flute is formed so that said rib (70, 124, 170, 172) extends outwardly from the cam surface at a location wherein the bur head has a maximum diameter.