An expandable support device configured for delivering an operative member through a working channel to a target treatment area, the device comprising: an elastomeric body configured to support the operative member and promote expansion of the expandable support device between a collapsed configuration and an expanded configuration, the elastomeric body comprising: a proximal portion configured for coupling the elastomeric body with a guide assembly; a distal portion opposite the proximal portion; and a central axis extending between the distal portion and the proximal portion of the elastomeric body; and expandable support device further comprises: a central support (155-c-2) coupled with the elastomeric body and aligned parallel to the central axis and extending along at least a portion of the central axis of the elastomeric body; a first peripheral support (155-c-1) coupled with the elastomeric body and arranged parallel to the central support and at a first periphery of the elastomeric body; and a second peripheral support (155-c-3) coupled with the elastomeric body and arranged parallel to the central support and at a second periphery of the elastomeric body opposite the first periphery, wherein at least one of the supports (155-c-1,155-c-2,155-c-3) comprises at least a highly elastic or superelastic material, characterized in that an operative member is an ablation device and is disposed on the elastomeric body and wherein at least two of the supports (155-c-1, 155-c-2,155-c-3) are formed of different materials. an elastomeric body configured to support the operative member and promote expansion of the expandable support device between a collapsed configuration and an expanded configuration, the elastomeric body comprising: a proximal portion configured for coupling the elastomeric body with a guide assembly; a distal portion opposite the proximal portion; and a central axis extending between the distal portion and the proximal portion of the elastomeric body; and expandable support device further comprises: a central support (155-c-2) coupled with the elastomeric body and aligned parallel to the central axis and extending along at least a portion of the central axis of the elastomeric body; a first peripheral support (155-c-1) coupled with the elastomeric body and arranged parallel to the central support and at a first periphery of the elastomeric body; and a second peripheral support (155-c-3) coupled with the elastomeric body and arranged parallel to the central support and at a second periphery of the elastomeric body opposite the first periphery, a proximal portion configured for coupling the elastomeric body with a guide assembly; a distal portion opposite the proximal portion; and a central axis extending between the distal portion and the proximal portion of the elastomeric body; and expandable support device further comprises: a central support (155-c-2) coupled with the elastomeric body and aligned parallel to the central axis and extending along at least a portion of the central axis of the elastomeric body; a first peripheral support (155-c-1) coupled with the elastomeric body and arranged parallel to the central support and at a first periphery of the elastomeric body; and a second peripheral support (155-c-3) coupled with the elastomeric body and arranged parallel to the central support and at a second periphery of the elastomeric body opposite the first periphery, a central support (155-c-2) coupled with the elastomeric body and aligned parallel to the central axis and extending along at least a portion of the central axis of the elastomeric body; a first peripheral support (155-c-1) coupled with the elastomeric body and arranged parallel to the central support and at a first periphery of the elastomeric body; and a second peripheral support (155-c-3) coupled with the elastomeric body and arranged parallel to the central support and at a second periphery of the elastomeric body opposite the first periphery,