A hair regrowth composition, comprising: a) a safe and effective amount of at least one hair growth active selected from the group consisting of minoxidil; and b) from 0.1% to 99% by weight of an admixture, comprising: i. from 0.01% to 99.98% by weight of the admixture of a pyruvic acid selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, methyl pyruvate, salts thereof, and mixtures thereof; ii. from 0.01 % to 99.98% by weight of the admixture of an antioxidant; and iii. from 0.01 % to 99.98% by weight of the admixture of a fatty acid mixture comprising at least 7 unsaturated or saturated fatty acids selected from the group consisting of butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, pentadecanoic acid, margaric acid, margaroleic acid, behenic acid, dihomolinoleic acid, arachidonic acid and lignoceric acid; for use in a therapeutic method of reducing hair loss and/or facilitating hair growth or hair regrowth, wherein the composition is applied to the skin of a mammal. a) a safe and effective amount of at least one hair growth active selected from the group consisting of minoxidil; and b) from 0.1% to 99% by weight of an admixture, comprising: i. from 0.01% to 99.98% by weight of the admixture of a pyruvic acid selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, methyl pyruvate, salts thereof, and mixtures thereof; ii. from 0.01 % to 99.98% by weight of the admixture of an antioxidant; and iii. from 0.01 % to 99.98% by weight of the admixture of a fatty acid mixture comprising at least 7 unsaturated or saturated fatty acids selected from the group consisting of butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, pentadecanoic acid, margaric acid, margaroleic acid, behenic acid, dihomolinoleic acid, arachidonic acid and lignoceric acid; i. from 0.01% to 99.98% by weight of the admixture of a pyruvic acid selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, methyl pyruvate, salts thereof, and mixtures thereof; ii. from 0.01 % to 99.98% by weight of the admixture of an antioxidant; and iii. from 0.01 % to 99.98% by weight of the admixture of a fatty acid mixture comprising at least 7 unsaturated or saturated fatty acids selected from the group consisting of butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, pentadecanoic acid, margaric acid, margaroleic acid, behenic acid, dihomolinoleic acid, arachidonic acid and lignoceric acid;