A diffusion-based, continuous-monitoring system for analyzing the effect of at least one allergen on a patient, the diffusion-based, continuous-monitoring system comprising: means for creating at least one diffusion channel in an area of skin of the patient for diffusing at least one of an antibody, a histamine, a leukotriene, and prostaglandins from the skin, wherein the means for creating at least one diffusion channel include at least one of the following: means for performing skin abrasion, means for performing microporation, means for performing microneedle-diffusion enhancement, pressure members, lancets, means for performing ultrasound, and means for performing laser ablation; means for maintaining the at least one diffusion channel for a desired continuous duration of time, wherein the means for maintaining the at least one diffusion channel includes chemical agents or physical agents, or both, that increase and maintain porosity of the area of skin; means for applying at least one selected allergen to the area of skin, wherein the means for applying at least one selected allergen to the area of skin are means for contacting the skin with at least one allergen at or near the at least one diffusion channel; means for continuously monitoring information relating to at least one of an antibody, a histamine, a leukotriene, and prostaglandins at the area of skin for the desired continuous duration of time wherein the means for continuously monitoring information is a diffusion-based, continuous-monitoring device, comprising an analysis component for analyzing at least one of an antibody, a histamine, a leukotriene, and prostaglandins that is diffused from the skin through the at least one diffusion channel, the analysis component being adapted to continuously monitor at least one of amounts, relative concentrations, absolute concentrations, and ratios for at least one of an antibody, a histamine, a leukotriene, and prostaglandins for the desired continuous duration of time to identify a quantity of the at least one allergen at which the at least one allergen causes an allergic effect, the analysis component including at least one of the following: an electrochemical-monitoring system, an optical-monitoring system, an osmotic-monitoring system, and a pressure-monitoring system; and means for analyzing the information relating to the at least one of an antibody, a histamine, a leukotriene, and prostaglandins at the area of skin to identify a quantify of the at least one selected allergen at which the at least one selected allergen causes an allergic effect, the means for analyzing the information comprising a processor for processing the at least one of amounts, relative concentrations, absolute concentrations, and ratios for the at least one of an antibody, a histamine, a leukotriene, and prostaglandins. means for creating at least one diffusion channel in an area of skin of the patient for diffusing at least one of an antibody, a histamine, a leukotriene, and prostaglandins from the skin, wherein the means for creating at least one diffusion channel include at least one of the following: means for performing skin abrasion, means for performing microporation, means for performing microneedle-diffusion enhancement, pressure members, lancets, means for performing ultrasound, and means for performing laser ablation; means for maintaining the at least one diffusion channel for a desired continuous duration of time, wherein the means for maintaining the at least one diffusion channel includes chemical agents or physical agents, or both, that increase and maintain porosity of the area of skin; means for applying at least one selected allergen to the area of skin, wherein the means for applying at least one selected allergen to the area of skin are means for contacting the skin with at least one allergen at or near the at least one diffusion channel; means for continuously monitoring information relating to at least one of an antibody, a histamine, a leukotriene, and prostaglandins at the area of skin for the desired continuous duration of time wherein the means for continuously monitoring information is a diffusion-based, continuous-monitoring device, comprising an analysis component for analyzing at least one of an antibody, a histamine, a leukotriene, and prostaglandins that is diffused from the skin through the at least one diffusion channel, the analysis component being adapted to continuously monitor at least one of amounts, relative concentrations, absolute concentrations, and ratios for at least one of an antibody, a histamine, a leukotriene, and prostaglandins for the desired continuous duration of time to identify a quantity of the at least one allergen at which the at least one allergen causes an allergic effect, the analysis component including at least one of the following: an electrochemical-monitoring system, an optical-monitoring system, an osmotic-monitoring system, and a pressure-monitoring system; and means for analyzing the information relating to the at least one of an antibody, a histamine, a leukotriene, and prostaglandins at the area of skin to identify a quantify of the at least one selected allergen at which the at least one selected allergen causes an allergic effect, the means for analyzing the information comprising a processor for processing the at least one of amounts, relative concentrations, absolute concentrations, and ratios for the at least one of an antibody, a histamine, a leukotriene, and prostaglandins.