An apparatus for rotating a cell growth chamber of a cell expansion system, the cell growth chamber including a longitudinal axis (LA-LA), the apparatus comprising: a shaft assembly including: an outer shaft member; an inner shaft member, wherein at least a portion of the inner shaft member is located radially to an interior of the outer shaft member, wherein the outer shaft member and the inner shaft member are substantially coaxial and share a shaft rotation axis, the inner shaft member including a beveled pinion at a distal end of the inner shaft member, wherein the beveled pinion is translatable longitudinally along the shaft rotation axis, the beveled pinion including a beveled surface; a first motor for rotating the outer shaft member; and a second motor for rotating the inner shaft member; a chamber coupling connected to the cell growth chamber, the chamber coupling including a shaft fitting for detachably engaging the outer shaft member, the chamber coupling including a roll collar located around at least a portion of the cell growth chamber, the roll collar including a sloped surface for engaging the beveled pinion; wherein when the first motor rotates the outer shaft member the cell growth chamber rotates around the shaft rotation axis, and wherein when the second motor rotates the inner shaft member the cell growth chamber rotates around the longitudinal axis of the cell growth chamber. a shaft assembly including: an outer shaft member; an inner shaft member, wherein at least a portion of the inner shaft member is located radially to an interior of the outer shaft member, wherein the outer shaft member and the inner shaft member are substantially coaxial and share a shaft rotation axis, the inner shaft member including a beveled pinion at a distal end of the inner shaft member, wherein the beveled pinion is translatable longitudinally along the shaft rotation axis, the beveled pinion including a beveled surface; a first motor for rotating the outer shaft member; and a second motor for rotating the inner shaft member; an outer shaft member; an inner shaft member, wherein at least a portion of the inner shaft member is located radially to an interior of the outer shaft member, wherein the outer shaft member and the inner shaft member are substantially coaxial and share a shaft rotation axis, the inner shaft member including a beveled pinion at a distal end of the inner shaft member, wherein the beveled pinion is translatable longitudinally along the shaft rotation axis, the beveled pinion including a beveled surface; a first motor for rotating the outer shaft member; and a second motor for rotating the inner shaft member; a chamber coupling connected to the cell growth chamber, the chamber coupling including a shaft fitting for detachably engaging the outer shaft member, the chamber coupling including a roll collar located around at least a portion of the cell growth chamber, the roll collar including a sloped surface for engaging the beveled pinion; wherein when the first motor rotates the outer shaft member the cell growth chamber rotates around the shaft rotation axis, and wherein when the second motor rotates the inner shaft member the cell growth chamber rotates around the longitudinal axis of the cell growth chamber.