mhurhangee/ep-ind-claims huggingface dataset:
A bispecific antibody or antigen-binding fragment thereof comprising: a first heavy chain variable region, a second heavy chain variable region, a first light chain variable region, and a second light chain variable region, wherein the VH1 and the VL1 associate with each other, forming a first antigen binding region that specifically binds to CD20, and the VH2 and the VL2 associate with each other, forming a second antigen binding region that specifically binds to CD3, wherein the VL1 and the VL2 are identical, and wherein the VH1 comprises an amino acid sequence that is identical to SEQ ID NO: 1; the VH2 comprises an amino acid sequence that is identical to SEQ ID NO: 2; the VL1 comprises an amino acid sequence that is identical to SEQ ID NO: 3; and the VL2 comprises an amino acid sequence that is identical to SEQ ID NO: 3. a first heavy chain variable region, a second heavy chain variable region, a first light chain variable region, and a second light chain variable region, wherein the VH1 and the VL1 associate with each other, forming a first antigen binding region that specifically binds to CD20, and the VH2 and the VL2 associate with each other, forming a second antigen binding region that specifically binds to CD3, wherein the VL1 and the VL2 are identical, and wherein the VH1 comprises an amino acid sequence that is identical to SEQ ID NO: 1; the VH2 comprises an amino acid sequence that is identical to SEQ ID NO: 2; the VL1 comprises an amino acid sequence that is identical to SEQ ID NO: 3; and the VL2 comprises an amino acid sequence that is identical to SEQ ID NO: 3.
A suds removal method of a washing machine, the method comprising: i) sensing generation of suds during a washing cycle; and ii) removing the suds by adjusting an activity of the suds depending on the supply amount of water and an operation rate of the motor if the generation of suds is sensed, characterized in that the sensing of generation of suds comprises the following substeps: a) primarily sensing the generation of suds by detecting a torque variation of a motor during the washing cycle, and b) secondarily sensing the generation of suds by performing a drainage operation after ending the washing cycle when the generation of suds is primarily sensed wherein the secondary sensing of the generation of suds is performed by determining whether water reaches a drainage ending level within a predetermined drainage time during the drainage operation, thereby sensing the generation of suds if the water does not reach the drainage ending level within the predetermined drainage time. i) sensing generation of suds during a washing cycle; and ii) removing the suds by adjusting an activity of the suds depending on the supply amount of water and an operation rate of the motor if the generation of suds is sensed, characterized in that a) primarily sensing the generation of suds by detecting a torque variation of a motor during the washing cycle, and b) secondarily sensing the generation of suds by performing a drainage operation after ending the washing cycle when the generation of suds is primarily sensed
A method for nucleic acid sequencing comprising: providing a substrate comprising an array of nanoFETs, each comprising a source, a drain, and a gate, wherein a plurality of the nanoFETs comprise a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid, the complex attached to the gate of the nanoFET, wherein the polymerase enzyme is attached to the gate in an orientation whereby the nucleotide exit region of the polymerase enzyme is toward the gate of the nanoFET; exposing the substrate to a plurality of types of nucleotide analogs, each comprising a different conductivity label attached to the phosphate portion of the nucleotide analog through a linker under conditions whereby polymerase mediated nucleic acid synthesis occurs, resulting in cleavage of the conductivity label and the growth of a nascent nucleic acid strand; applying a voltage between the source and drain, whereby when a nucleotide analog resides in the active site of the enzyme, the conductivity label on the nucleotide analog produces a measurable change in the electrical signal at the gate; monitoring an electrical signal at the gate over time, whereby the electrical signal indicates an incorporation event for a type of nucleotide analog having a specific conductivity label; and using the electrical signal to determine a sequence of the template nucleic acid. providing a substrate comprising an array of nanoFETs, each comprising a source, a drain, and a gate, wherein a plurality of the nanoFETs comprise a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid, the complex attached to the gate of the nanoFET, wherein the polymerase enzyme is attached to the gate in an orientation whereby the nucleotide exit region of the polymerase enzyme is toward the gate of the nanoFET; exposing the substrate to a plurality of types of nucleotide analogs, each comprising a different conductivity label attached to the phosphate portion of the nucleotide analog through a linker under conditions whereby polymerase mediated nucleic acid synthesis occurs, resulting in cleavage of the conductivity label and the growth of a nascent nucleic acid strand; applying a voltage between the source and drain, whereby when a nucleotide analog resides in the active site of the enzyme, the conductivity label on the nucleotide analog produces a measurable change in the electrical signal at the gate; monitoring an electrical signal at the gate over time, whereby the electrical signal indicates an incorporation event for a type of nucleotide analog having a specific conductivity label; and using the electrical signal to determine a sequence of the template nucleic acid.
A compound with the general formula: where: R1 denotes a linear or branched C1-C8 alkyl, phenyl, benzyl; R2 denotes a hydrogen, an alkyl 2-formamidoacetate group wherein the alkyl group is a linear or branched C1-C8 chain; and R3 denotes a carboxylic acid acyl group selected from among 2,6-dichlorobenzoic or 2,6-di(trifluoromethyl)benzoic acid groups; or its pharmaceutically permissible salt. R1 denotes a linear or branched C1-C8 alkyl, phenyl, benzyl; R2 denotes a hydrogen, an alkyl 2-formamidoacetate group wherein the alkyl group is a linear or branched C1-C8 chain; and R3 denotes a carboxylic acid acyl group selected from among 2,6-dichlorobenzoic or 2,6-di(trifluoromethyl)benzoic acid groups; or its pharmaceutically permissible salt.
An injection device comprising: a cartridge configured to hold a volume of fluid, the cartridge having a proximal end and a distal end (104a, 104b) through which the fluid is dispensed; a first stopper disposed in the cartridge and configured to move from the proximal end toward the distal end (104a, 104b) to cause the fluid to be dispensed through the distal end (104a, 104b) of the cartridge; a second stopper disposed at the distal end (104a, 104b) of the cartridge, the second stopper including an aperture through which the fluid is dispensed; a reflector (120a, 120b) disposed at the distal end (104a, 104b) of the cartridge; and a transmitter and a receiver disposed in the first stopper, the transmitter configured to transmit one or more waves toward the reflector (120a, 120b) and the receiver configured to receive reflections of the one or more waves from at least the reflector (120a, 120b), wherein the cartridge comprises a material that allows the one or more waves and the reflections of the one or more waves to pass therethrough, characterized in that the reflector (120a, 120b) comprises a ceramic material or a biaxially-oriented polyethylene terephthalate material. a cartridge configured to hold a volume of fluid, the cartridge having a proximal end and a distal end (104a, 104b) through which the fluid is dispensed; a first stopper disposed in the cartridge and configured to move from the proximal end toward the distal end (104a, 104b) to cause the fluid to be dispensed through the distal end (104a, 104b) of the cartridge; a second stopper disposed at the distal end (104a, 104b) of the cartridge, the second stopper including an aperture through which the fluid is dispensed; a reflector (120a, 120b) disposed at the distal end (104a, 104b) of the cartridge; and a transmitter and a receiver disposed in the first stopper, the transmitter configured to transmit one or more waves toward the reflector (120a, 120b) and the receiver configured to receive reflections of the one or more waves from at least the reflector (120a, 120b), wherein the cartridge comprises a material that allows the one or more waves and the reflections of the one or more waves to pass therethrough, characterized in that the reflector (120a, 120b) comprises a ceramic material or a biaxially-oriented polyethylene terephthalate material.
A resource scheduling method, wherein the method comprises: receiving, by user equipment over a first control channel, said channel being a physical downlink control channel, first indication information corresponding to a transport block, wherein time-frequency resources used for transmission of the transport block divide into a first resource set and a second resource set, where each set corresponds to different, non-overlapping portions of a system bandwidth in a time slot in which the first control channel and a second control channel are transmitted, and the first indication information is used to indicate the first resource set and a time-frequency resource of the second control channel; receiving, by the user equipment, second indication information over the second control channel, wherein the second indication information is used to indicate the second resource set; and determining, by the user equipment, the transport block based on the first resource set and the second resource set. receiving, by user equipment over a first control channel, said channel being a physical downlink control channel, first indication information corresponding to a transport block, wherein time-frequency resources used for transmission of the transport block divide into a first resource set and a second resource set, where each set corresponds to different, non-overlapping portions of a system bandwidth in a time slot in which the first control channel and a second control channel are transmitted, and the first indication information is used to indicate the first resource set and a time-frequency resource of the second control channel; receiving, by the user equipment, second indication information over the second control channel, wherein the second indication information is used to indicate the second resource set; and determining, by the user equipment, the transport block based on the first resource set and the second resource set.
A phosphate based oligomeric compound, comprising a repeating unit represented by the structure of formula: and a linker represented by the structure of formula, derived from the monomeric splitting precursor of claim 18: which links between phosphate groups of the repeating units represented by structure formula, and serves as a splitting point from where two oligomeric branches comprising the structure of formula depart, wherein Y is a delivery group or a pro-delivery group; wherein said delivery group is amine, histidine, guanidine, polyguanidine, imidazole, polyimidazole or any combination thereof; wherein said pro-delivery group is a functional group that can be chemically converted to the delivery group; w, w' and w" are each independently an integer between 0 and 10; and p is an integer between 0 and 10. which links between phosphate groups of the repeating units represented by structure formula, and serves as a splitting point from where two oligomeric branches comprising the structure of formula depart, wherein Y is a delivery group or a pro-delivery group; wherein said delivery group is amine, histidine, guanidine, polyguanidine, imidazole, polyimidazole or any combination thereof; wherein said pro-delivery group is a functional group that can be chemically converted to the delivery group; w, w' and w" are each independently an integer between 0 and 10; and p is an integer between 0 and 10.
A method for producing unique instances of a host image from a host image design file, each unique instance having a unique digital payload, the method comprising: embedding a reference digital watermark in the image from the host image design file to produce a marked base image, the embedding determining embedding parameters, wherein the embedding parameters determine positive or negative adjustments of ink coverage within an allowable adjustment range according to visibility and robustness metrics; from the embedding parameters, computing allowable adjustments for producing final marked images with unique digital payloads, wherein each of the final marked images is a unique instance of the host image from the host image design file, and wherein the allowable adjustments provide an adjustment for embedding locations within plural tiles of the host image, each unique payload corresponding to particular payload adjustments that are a subset of the allowable adjustments; forming a database of the allowable adjustments, the database being configured to provide the particular payload adjustments from the allowable adjustments for the embedding locations according to values within a watermark signal tile of a unique payload; and receiving, from the database, adjustment quantities and locations of the particular payload adjustments for a unique digital payload, and making the particular payload adjustments to pixels of the host image to encode the unique digital payload. embedding a reference digital watermark in the image from the host image design file to produce a marked base image, the embedding determining embedding parameters, wherein the embedding parameters determine positive or negative adjustments of ink coverage within an allowable adjustment range according to visibility and robustness metrics; from the embedding parameters, computing allowable adjustments for producing final marked images with unique digital payloads, wherein each of the final marked images is a unique instance of the host image from the host image design file, and wherein the allowable adjustments provide an adjustment for embedding locations within plural tiles of the host image, each unique payload corresponding to particular payload adjustments that are a subset of the allowable adjustments; forming a database of the allowable adjustments, the database being configured to provide the particular payload adjustments from the allowable adjustments for the embedding locations according to values within a watermark signal tile of a unique payload; and receiving, from the database, adjustment quantities and locations of the particular payload adjustments for a unique digital payload, and making the particular payload adjustments to pixels of the host image to encode the unique digital payload.
A puncture closure device, comprising: an anchor support including a coupling feature, the anchor support having a first end and a second end; an anchor connected to the anchor support, wherein the anchor is configured for insertion through a puncture; a removable placement rod positioned adjacent the first end of the anchor support; a movable, ring-shaped compression element configured to be movable between a first position and a second position, wherein movement of the compression element to the second position causes coupling of the compression element to the coupling feature of the anchor support; a sealing plug positioned generally between the compression element and the anchor, the sealing plug having a bore; wherein the compression element is configured to cause compression of the sealing plug generally between the compression element and the anchor upon movement of the compression element from the first position to the second position, with the removable placement rod being separable from the anchor support when the compression element is in the second position, characterized in that, when the compression element is in the first position, the compression element is positioned about a portion of the circumference of the removable placement rod and the bore of the sealing plug is positioned generally about a portion of the circumference of the removable placement rod. an anchor support including a coupling feature, the anchor support having a first end and a second end; an anchor connected to the anchor support, wherein the anchor is configured for insertion through a puncture; a removable placement rod positioned adjacent the first end of the anchor support; a movable, ring-shaped compression element configured to be movable between a first position and a second position, wherein movement of the compression element to the second position causes coupling of the compression element to the coupling feature of the anchor support; a sealing plug positioned generally between the compression element and the anchor, the sealing plug having a bore; wherein the compression element is configured to cause compression of the sealing plug generally between the compression element and the anchor upon movement of the compression element from the first position to the second position, with the removable placement rod being separable from the anchor support when the compression element is in the second position, characterized in that, when the compression element is in the first position, the compression element is positioned about a portion of the circumference of the removable placement rod and the bore of the sealing plug is positioned generally about a portion of the circumference of the removable placement rod.
A device for treating regurgitation through a gap in a valve in a heart, the heart having an atrium fluidically coupled to a ventricle by the valve, the valve defining a valve plane including at least two leaflets extending from an annulus defining an anterior and posterior annulus, the at least two leaflets coapting along a line of coaptation, the device comprising: a frame sized to fit within a heart chamber, the frame including: an upper portion, a lower portion, and a middle portion, a pair of arms (4035, 4040) moveably coupled to the frame; and a compliant membrane covering the frame and at least a portion of the pair of arms (4035, 4040), the upper portion of the frame being configured, in use, to rest above the valve plane such that upper portion contacts or rests upon the anterior and posterior annulus, and the lower portion of the frame being configured to capture the leaflets and close the gap between the leaflets as well as to keep the device in position within the valve. a frame sized to fit within a heart chamber, the frame including: an upper portion, a lower portion, and a middle portion, an upper portion, a lower portion, and a middle portion, a pair of arms (4035, 4040) moveably coupled to the frame; and a compliant membrane covering the frame and at least a portion of the pair of arms (4035, 4040), the upper portion of the frame being configured, in use, to rest above the valve plane such that upper portion contacts or rests upon the anterior and posterior annulus, and the lower portion of the frame being configured to capture the leaflets and close the gap between the leaflets as well as to keep the device in position within the valve.
An absorbent article comprising: a chassis comprising an outer cover having an interior surface and an exterior surface and an absorbent structure positioned adjacent the interior surface of the outer cover; a non-contact electronic sensor array, the non-contact electronic sensor array comprising a plurality of gas sensors, where each gas sensor separately monitors the level of gas associated with a particular volatile compound and wherein the non-contact electronic sensor array monitors gas concentration levels of gases emitted after an insult by two or more volatile compounds within the absorbent article; a controller configured to detect changes above a threshold level in the gas concentration levels of the plurality of gas sensors within the non-contact electronic sensor array as the result of an insult within the absorbent article, wherein the insult is urine, bowel movement, or combinations thereof; and a signaling device that alerts a user of changes in the gas concentration levels detected by the controller. a chassis comprising an outer cover having an interior surface and an exterior surface and an absorbent structure positioned adjacent the interior surface of the outer cover; a non-contact electronic sensor array, the non-contact electronic sensor array comprising a plurality of gas sensors, where each gas sensor separately monitors the level of gas associated with a particular volatile compound and wherein the non-contact electronic sensor array monitors gas concentration levels of gases emitted after an insult by two or more volatile compounds within the absorbent article; a controller configured to detect changes above a threshold level in the gas concentration levels of the plurality of gas sensors within the non-contact electronic sensor array as the result of an insult within the absorbent article, wherein the insult is urine, bowel movement, or combinations thereof; and a signaling device that alerts a user of changes in the gas concentration levels detected by the controller.
A meter bypass adapter comprising: a body having: a first port; a second port; a third port; and a fourth port; and at least one valve element (92/94) held by the body and moveable between: a first position wherein a flowpath is open from the first port to the second port and a flowpath is open from the third port to the fourth port without a direct flowpath from the first port to the fourth port; and a second position wherein a flowpath extends from the first port to the fourth port bypassing the second port and the third port; and a single rotary actuator held by the body to rotate about an axis and, in turn, shift the least one valve element (92/94) between the first position and the second position wherein the at least one valve element (92/94) comprises a first valve element and a second valve element wherein movement of the first valve element between its first position and its second position is linearly opposite movement of the second valve element between its first position and its second position. a body having: a first port; a second port; a third port; and a fourth port; and a first port; a second port; a third port; and a fourth port; and at least one valve element (92/94) held by the body and moveable between: a first position wherein a flowpath is open from the first port to the second port and a flowpath is open from the third port to the fourth port without a direct flowpath from the first port to the fourth port; and a second position wherein a flowpath extends from the first port to the fourth port bypassing the second port and the third port; and a first position wherein a flowpath is open from the first port to the second port and a flowpath is open from the third port to the fourth port without a direct flowpath from the first port to the fourth port; and a second position wherein a flowpath extends from the first port to the fourth port bypassing the second port and the third port; and a single rotary actuator held by the body to rotate about an axis and, in turn, shift the least one valve element (92/94) between the first position and the second position wherein the at least one valve element (92/94) comprises a first valve element and a second valve element wherein movement of the first valve element between its first position and its second position is linearly opposite movement of the second valve element between its first position and its second position.