A compound of Formula II: wherein: R 2q is hydrogen or halogen; R 3q is hydrogen, halogen, or cyano; R 5q is hydrogen, alkyl, or cyano; R 7q is alkoxy, -OSO 2 -heterocy -O-arylalkyl, -NR'-SO 2 -alkyl -NR'-C -alkyl, -NR'-C -NR'-alkyl, -NR'-C -O-alkyl, haloalkyl, or alkyl optionally substituted with heterocyclyl, -NR'-SO 2 -alkyl, -NR'-SO 2 -haloalkyl, NR'-C -alkyl, NR'-C -heterocyclyl, -NR'-C -NR'-alkyl, or-NR'-C -O-alkyl; R 8q is hydrogen, alkyl, hydroxyalkyl, -alkyl-OC -alkyl, carboxylate, alkoxycarbonyl, or arylalkyl substituted with alkyl, or aroyl substituted with cyano and/or alkyl, or -alkyl-O-aryl substituted with alkoxycarbonyl; each R' is independently hydrogen, C 1 -C 4 -alkyl, or C 3 -C 6 -cycloalkyl; and pharmaceutically acceptable salts thereof; with the proviso that when R 5q is cyano, then at least one of R 2q, R 3q, and R 8q is other than hydrogen; and wherein: the term "alkyl" represents C 1 -C 4 -alkyl; the term "alkoxy" represents alkyl, alkenyl, and alkynyl groups covalently linked to an oxygen atom; the term "alkenyl" represents C 2 -C 4 -alkenyl; the term "alkynyl" represents C 2 -C 4 -alkynyl; the term "heterocyclyl" represents an optionally substituted, saturated or unsaturated non-aromatic ring or ring system, which is a 4-, 5-, 6-, or 7-membered monocyclic, 7-, 8-, 9-, 10-, 11-, or 12-membered bicyclic or 10-, 11-, 12-, 13-, 14- or 15-membered tricyclic ring system and contains at least one heteroatom selected from O, S and N, where the N and S can also optionally be oxidized to various oxidation states; the term "aryl" represents optionally substituted 5- and 6-membered single-ring aromatic groups that may include from zero to four heteroatoms; and the term "aroyl" represents an aryl bound to a carbonyl group. R 2q is hydrogen or halogen; R 3q is hydrogen, halogen, or cyano; R 5q is hydrogen, alkyl, or cyano; R 7q is alkoxy, -OSO 2 -heterocy -O-arylalkyl, -NR'-SO 2 -alkyl -NR'-C -alkyl, -NR'-C -NR'-alkyl, -NR'-C -O-alkyl, haloalkyl, or alkyl optionally substituted with heterocyclyl, -NR'-SO 2 -alkyl, -NR'-SO 2 -haloalkyl, NR'-C -alkyl, NR'-C -heterocyclyl, -NR'-C -NR'-alkyl, or-NR'-C -O-alkyl; R 8q is hydrogen, alkyl, hydroxyalkyl, -alkyl-OC -alkyl, carboxylate, alkoxycarbonyl, or arylalkyl substituted with alkyl, or aroyl substituted with cyano and/or alkyl, or -alkyl-O-aryl substituted with alkoxycarbonyl; each R' is independently hydrogen, C 1 -C 4 -alkyl, or C 3 -C 6 -cycloalkyl; and pharmaceutically acceptable salts thereof; with the proviso that when R 5q is cyano, then at least one of R 2q, R 3q, and R 8q is other than hydrogen; and wherein: the term "alkyl" represents C 1 -C 4 -alkyl; the term "alkoxy" represents alkyl, alkenyl, and alkynyl groups covalently linked to an oxygen atom; the term "alkenyl" represents C 2 -C 4 -alkenyl; the term "alkynyl" represents C 2 -C 4 -alkynyl; the term "heterocyclyl" represents an optionally substituted, saturated or unsaturated non-aromatic ring or ring system, which is a 4-, 5-, 6-, or 7-membered monocyclic, 7-, 8-, 9-, 10-, 11-, or 12-membered bicyclic or 10-, 11-, 12-, 13-, 14- or 15-membered tricyclic ring system and contains at least one heteroatom selected from O, S and N, where the N and S can also optionally be oxidized to various oxidation states; the term "aryl" represents optionally substituted 5- and 6-membered single-ring aromatic groups that may include from zero to four heteroatoms; and the term "aroyl" represents an aryl bound to a carbonyl group. the term "alkyl" represents C 1 -C 4 -alkyl; the term "alkoxy" represents alkyl, alkenyl, and alkynyl groups covalently linked to an oxygen atom; the term "alkenyl" represents C 2 -C 4 -alkenyl; the term "alkynyl" represents C 2 -C 4 -alkynyl; the term "heterocyclyl" represents an optionally substituted, saturated or unsaturated non-aromatic ring or ring system, which is a 4-, 5-, 6-, or 7-membered monocyclic, 7-, 8-, 9-, 10-, 11-, or 12-membered bicyclic or 10-, 11-, 12-, 13-, 14- or 15-membered tricyclic ring system and contains at least one heteroatom selected from O, S and N, where the N and S can also optionally be oxidized to various oxidation states; the term "aryl" represents optionally substituted 5- and 6-membered single-ring aromatic groups that may include from zero to four heteroatoms; and the term "aroyl" represents an aryl bound to a carbonyl group.