A tissue resection device, comprising: a handle portion; a clamping mechanism extending from the handle portion and which defines a confined region sized to receive a tissue region of interest therebetween, wherein the clamping mechanism comprises at least two distally extending members (2204A, 2204B) each defining a curvature or angle extending away relative to one another and which define the confined region, and wherein each of the at least two distally extending members (2204A, 2204B) terminate in a piercing tip (2206A, 2206B) which extends distally in a direction of the extending members (2204A, 2204B) for insertion directly into the tissue region of interest; and an elongate coring needle defining a lumen and having a distal end which defines a cutting mechanism, wherein the coring needle is translatable along the distally extending members (2204A, 2204B) such that the coring needle envelops the confined region, wherein the curvature or angle of the extending members (2204A, 2204B) extends radially such that the extending members (2204A, 2204B) are urged towards one another when the coring needle is translated distally over the extending members (2204A, 2204B), and wherein the elongate coring needle is rotatable about the at least two distally extending members (2204A, 2204B) as the coring needle is translated distally relative to the at least two distally extending members (2204A, 2204B) such that advancement of the coring needle actuates the extending members (2204A, 2204B) to clamp upon the tissue region between the distally extending members (2204A, 2204B) and envelop the confined region while cutting tissue via the cutting mechanism. a handle portion; a clamping mechanism extending from the handle portion and which defines a confined region sized to receive a tissue region of interest therebetween, wherein the clamping mechanism comprises at least two distally extending members (2204A, 2204B) each defining a curvature or angle extending away relative to one another and which define the confined region, and wherein each of the at least two distally extending members (2204A, 2204B) terminate in a piercing tip (2206A, 2206B) which extends distally in a direction of the extending members (2204A, 2204B) for insertion directly into the tissue region of interest; and an elongate coring needle defining a lumen and having a distal end which defines a cutting mechanism, wherein the coring needle is translatable along the distally extending members (2204A, 2204B) such that the coring needle envelops the confined region, wherein the curvature or angle of the extending members (2204A, 2204B) extends radially such that the extending members (2204A, 2204B) are urged towards one another when the coring needle is translated distally over the extending members (2204A, 2204B), and wherein the elongate coring needle is rotatable about the at least two distally extending members (2204A, 2204B) as the coring needle is translated distally relative to the at least two distally extending members (2204A, 2204B) such that advancement of the coring needle actuates the extending members (2204A, 2204B) to clamp upon the tissue region between the distally extending members (2204A, 2204B) and envelop the confined region while cutting tissue via the cutting mechanism.