A compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R 2 and R 3 are each independently chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-member or 6-member heteroaryl ring, wherein at least one ring atom is a heteroatom chosen from nitrogen, oxygen, and sulfur; or R 2 and R 3 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms; R 4 is a unit chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-member or 6-member heteroaryl ring, wherein at least one ring atom is a heteroatom chosen from nitrogen, oxygen, and sulfur; said substitutions for R, R 2, R 3, and R 4 are independently chosen from one or more C 1 -C 6 linear, branched, or cyclic alkyl, -N(R 16) 2, -OR 16, halogen, or cyano units; each R 16 is independently hydrogen, C 1 -C 4 linear, branched, or cyclic alkyl; Z is a unit having the formula: R 1 is chosen from: i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted C 6 aryl, wherein each substitution is independently chosen from halogen, C 1 -C 4 linear, branched, or cyclic alkyl, -OR 11, -CN, -N(R 11) 2, -CO 2 R 11, -C N(R 11) 2, -NR 11 C R 11, -NO 2, and -SO 2 R 11, each R 11 is independently hydrogen, substituted or unsubstituted C 1 -C 4 linear, branched, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted phenyl or benzyl; or two R 11 units can be taken together to form a ring comprising from 3-7 atoms; iv) substituted or unsubstituted C1-C 9 heterocyclic rings, wherein the heteroatoms are chosen from nitrogen, oxygen, and sulfur; or v) substituted or unsubstituted C 1 -C 9 heteroaryl rings, wherein at least one ring atom is a heteroatom selected from nitrogen, oxygen or sulfur; L is a linking unit chosen from: i) -C NH[C(R 5a R 5b)] w -; ii) -C [C(R 6a R 6b)]) x -; iii) -C [C(R 7a R 7b)] y C -; iv) -SO 2 [C(R 8a R 8b)] z -; R 5a, R 5b, R 6a, R 6b, R 7a, R 7b, R 8a, and R 8b are each independently: i) hydrogen; ii) substituted or unsubstituted C 1 -C 4 linear or branched alkyl; iii) substituted or unsubstituted aryl; iv) substituted or unsubstituted heterocyclic rings; or v) substituted or unsubstituted C 1 -C 9 heteroaryl; said substitutions for R 1, R 5a, R 5b, R 6a, R 6b, R 7a, R 7b, R 8a, and R 8b are independently chosen from C 1 -C 6 linear, branched, or cyclic alkyl, phenyl and benzyl, C 1 -C 9 heteroaryl, -C R 9, and -NHC R 9; R 9 is C 1 -C 6 linear and branched alkyl; C 1 -C 6 linear and branched alkoxy; or -NHCH 2 C R 10; R 10 is chosen from hydrogen, methyl, ethyl, and tert -butyl; the index n is 0 or 1; the indices w, x, y, and z are each independently from 1 to 4; or a pharmaceutically acceptable salt thereof. i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-member or 6-member heteroaryl ring, wherein at least one ring atom is a heteroatom chosen from nitrogen, oxygen, and sulfur; i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-member or 6-member heteroaryl ring, wherein at least one ring atom is a heteroatom chosen from nitrogen, oxygen, and sulfur; i) hydrogen; ii) substituted or unsubstituted C 1 -C 6 linear, branched, or cyclic alkyl; iii) substituted or unsubstituted C 6 aryl, wherein each substitution is independently chosen from halogen, C 1 -C 4 linear, branched, or cyclic alkyl, -OR 11, -CN, -N(R 11) 2, -CO 2 R 11, -C N(R 11) 2, -NR 11 C R 11, -NO 2, and -SO 2 R 11, each R 11 is independently hydrogen, substituted or unsubstituted C 1 -C 4 linear, branched, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted phenyl or benzyl; or two R 11 units can be taken together to form a ring comprising from 3-7 atoms; iv) substituted or unsubstituted C1-C 9 heterocyclic rings, wherein the heteroatoms are chosen from nitrogen, oxygen, and sulfur; or v) substituted or unsubstituted C 1 -C 9 heteroaryl rings, wherein at least one ring atom is a heteroatom selected from nitrogen, oxygen or sulfur; i) -C NH[C(R 5a R 5b)] w -; ii) -C [C(R 6a R 6b)]) x -; iii) -C [C(R 7a R 7b)] y C -; iv) -SO 2 [C(R 8a R 8b)] z -; i) hydrogen; ii) substituted or unsubstituted C 1 -C 4 linear or branched alkyl; iii) substituted or unsubstituted aryl; iv) substituted or unsubstituted heterocyclic rings; or v) substituted or unsubstituted C 1 -C 9 heteroaryl;