. A catheter site insertion plug comprising: a base that includes: a top surface and a bottom surface, and a body integrated with the base, the body having an upper surface, a lower, body-contacting surface, and a protruding portion extending from the lower surface, the protruding portion forming a frustum having a terminus, the body defining a passageway extending from an opening at the upper surface to an exit orifice at the terminus of the frustum, the passageway configured to receive a catheter therethrough, characterised in that: the protruding portion is formed of an elastomeric material, and the protruding portion further comprises an end section that extends radially outward to provide an inflection point generally adjacent the terminus of the frustum, the passageway defines a beveled or curved opening to the passageway at the upper surface to facilitate insertion of a catheter into the passageway, and the body further includes a second protruding portion extending from the bottom surface of the base, the second protruding portion being in the form of an annular ring around the first protruding portion. a base that includes: a top surface and a bottom surface, and a body integrated with the base, the body having an upper surface, a lower, body-contacting surface, and a protruding portion extending from the lower surface, the protruding portion forming a frustum having a terminus, the body defining a passageway extending from an opening at the upper surface to an exit orifice at the terminus of the frustum, the passageway configured to receive a catheter therethrough, a top surface and a bottom surface, and a body integrated with the base, the body having an upper surface, a lower, body-contacting surface, and a protruding portion extending from the lower surface, the protruding portion forming a frustum having a terminus, the body defining a passageway extending from an opening at the upper surface to an exit orifice at the terminus of the frustum, the passageway configured to receive a catheter therethrough, characterised in that: the protruding portion is formed of an elastomeric material, and the protruding portion further comprises an end section that extends radially outward to provide an inflection point generally adjacent the terminus of the frustum, the passageway defines a beveled or curved opening to the passageway at the upper surface to facilitate insertion of a catheter into the passageway, and the body further includes a second protruding portion extending from the bottom surface of the base, the second protruding portion being in the form of an annular ring around the first protruding portion. the protruding portion is formed of an elastomeric material, and the protruding portion further comprises an end section that extends radially outward to provide an inflection point generally adjacent the terminus of the frustum, the passageway defines a beveled or curved opening to the passageway at the upper surface to facilitate insertion of a catheter into the passageway, and the body further includes a second protruding portion extending from the bottom surface of the base, the second protruding portion being in the form of an annular ring around the first protruding portion.