mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula I: or a pharmaceutically acceptable salt thereof, for use in therapy by subcutaneous or intramuscular injection to deliver a parent drug compound of Formula II, wherein: each of X 1 to X 4 is independently N or CR, provided that at least one of X 1 -X 4 is CR; each R is independently hydrogen, or optionally substituted aliphatic, aromatic or heteroaromatic; or any 2 R groups can also be taken together with the carbon atoms to which they are attached to form a fused ring; R 5 is selected from -C(R 8)(R 9)-OC OR 10 and -C(R 8)(R 9)-OC R 10; R 8 and R 9 are each independently hydrogen or aliphatic; or R 8 is -C H or - CH CH 2 OH and R 9 is hydrogen; and R 10 is C 7 -C 24 -alkyl, C 7 -C 24 -alkenyl or C 7 -C 24 -alkynyl; and/or wherein X 1 to X 4 are such that the parent drug compound of formula II is mepiprazole, dexmedetomidine, albendazole, carbendazole, cyclobendazole, mebendazole, thiabendazole, almotriptan, dolasetron, eletriptan, lisuride, naratriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, ergotamine, alosetron, delavirdine, atevirdine, bopindolol, bucindolol, candesartan, deserpidine, mibefradil, ergoloid mesylate, indoramin, irbesartan, mepindolol, olmesartan, reserpine, rescinnamine, losartan, tasosartan, valsartan, raubasine, syrosingopine, carmoxirole, rescimetol, cabergoline, pergolide, bromocriptine, terguride, ambuphylline, cimetidine, lansoprazole, omeprazole, pantaprozole, rabeprazole, cefatrizine, daptomycin, ergonovine, methylergonovine, etodolac, liarozole, pemetrexed, thiamiprine, vinblastine, vincristine, vindesine, vinorelbine, voacamine, venflunine, oxypertine, indalpine, roxindole, pemirolast, tazanolast, traxanox, pimobendan, sulmazole, pranlukast, ramosetron, tropisetron, alizapride, bendazole, tadalafil, allopurinol, azathioprine, yohimbine, conivaptan, adrenoglomerulotropin, octreotide, somatostatin, exenatide, teriparatide, leuprorelin or goserelin. each of X 1 to X 4 is independently N or CR, provided that at least one of X 1 -X 4 is CR; each R is independently hydrogen, or optionally substituted aliphatic, aromatic or heteroaromatic; or any 2 R groups can also be taken together with the carbon atoms to which they are attached to form a fused ring; R 5 is selected from -C(R 8)(R 9)-OC OR 10 and -C(R 8)(R 9)-OC R 10; R 8 and R 9 are each independently hydrogen or aliphatic; or R 8 is -C H or - CH CH 2 OH and R 9 is hydrogen; and R 10 is C 7 -C 24 -alkyl, C 7 -C 24 -alkenyl or C 7 -C 24 -alkynyl; and/or
Chair, in particular office chair, with - a seat element, - a backrest, - a supporting framework on which the seat element and the backrest are placed, whereby the backrest and/or the seat element are formed by a backrest frame or a seat frame and a surface element stretched on the backrest frame and/or the seat frame and - a multitude of fixing elements worked out of the full edge all around for fixing to the backrest frame and/or the seat frame that are molded on the edge of the surface element and that form with the surface element a one-piece injection molded part, characterized in that the backrest frame or the seat frame comprises a tenter frame for stretching the surface element and a holding frame with which the tenter frame is connected. - a seat element, - a backrest, - a supporting framework on which the seat element and the backrest are placed, whereby the backrest and/or the seat element are formed by a backrest frame or a seat frame and a surface element stretched on the backrest frame and/or the seat frame and - a multitude of fixing elements worked out of the full edge all around for fixing to the backrest frame and/or the seat frame that are molded on the edge of the surface element and that form with the surface element a one-piece injection molded part,
A method for providing access to a service, comprising: receiving, by the service supported by a tenant of a multi-tenant system and from a client, an access request for accessing the service, the client configured with a digital certificate chain associated with the tenant; transmitting, by the service to the client, a first redirection response that indicates a mutual transport layer security service based at least in part on failing to receive a valid indication that the client is authenticated to access the service; receiving, from the client, an indication of a digitally signed version of the digital certificate chain, wherein the digital certificate chain is signed using a root key associated with the mutual transport layer security service that is trusted by the tenant; validating the digitally signed version of the digital certificate chain; and transmitting, to the client, an indication that the client is authenticated to access the service based at least in part on validating the digitally signed version of the digital certificate chain. receiving, by the service supported by a tenant of a multi-tenant system and from a client, an access request for accessing the service, the client configured with a digital certificate chain associated with the tenant; transmitting, by the service to the client, a first redirection response that indicates a mutual transport layer security service based at least in part on failing to receive a valid indication that the client is authenticated to access the service; receiving, from the client, an indication of a digitally signed version of the digital certificate chain, wherein the digital certificate chain is signed using a root key associated with the mutual transport layer security service that is trusted by the tenant; validating the digitally signed version of the digital certificate chain; and transmitting, to the client, an indication that the client is authenticated to access the service based at least in part on validating the digitally signed version of the digital certificate chain.
A method, comprising: controlling injection of a plurality of electrons to a correlated electron material of a correlated electron switch device (402, 502) such that the correlated electron material enters a first impedance state and to dynamically establish a threshold current density level for a subsequent operation to transition the correlated electron material to a second impedance state; and controlling injection of a plurality of holes to the correlated electron material to achieve the dynamically established threshold current density level such that the correlated electron material enters the second impedance state, the first and second impedance states respectively including resistance and capacitance characteristics, wherein the resistance and capacitance of the second impedance state exceeds the resistance and capacitance of the first impedance state. controlling injection of a plurality of electrons to a correlated electron material of a correlated electron switch device (402, 502) such that the correlated electron material enters a first impedance state and to dynamically establish a threshold current density level for a subsequent operation to transition the correlated electron material to a second impedance state; and controlling injection of a plurality of holes to the correlated electron material to achieve the dynamically established threshold current density level such that the correlated electron material enters the second impedance state, the first and second impedance states respectively including resistance and capacitance characteristics, wherein the resistance and capacitance of the second impedance state exceeds the resistance and capacitance of the first impedance state.
A screw vacuum pump, in particular for compression against atmospheric pressure, comprising a pump housing defining a suction chamber, two meshing screw rotors arranged in the suction chamber, a plurality of overpressure openings arranged in a side wall of the suction chamber and each connected with an overpressure outlet, at least two overpressure openings being arranged on different pressure levels, and overpressure valves arranged in the overpressure outlets, characterized in that the overpressure valves are configured as weight-loaded valves.
A molding apparatus that molds a metal pipe, comprising: an electrode (17, 18) which supplies electric power to a metal pipe material, thereby heating the metal pipe material; a gas supply unit which supplies gas into the heated metal pipe material, thereby expanding the metal pipe material; a mold which molds the metal pipe by bringing the expanded metal pipe material into contact therewith; and a drive unit which generates a driving force for moving the mold, characterised in that a replacement unit is replaceably provided with respect to a main body unit having at least the drive unit, and the replacement unit is configured of at least the electrode (17, 18), the gas supply unit and the mold. an electrode (17, 18) which supplies electric power to a metal pipe material, thereby heating the metal pipe material; a gas supply unit which supplies gas into the heated metal pipe material, thereby expanding the metal pipe material; a mold which molds the metal pipe by bringing the expanded metal pipe material into contact therewith; and a drive unit which generates a driving force for moving the mold, characterised in that a replacement unit is replaceably provided with respect to a main body unit having at least the drive unit, and the replacement unit is configured of at least the electrode (17, 18), the gas supply unit and the mold.
An injection molding machine comprising: a stationary platen; a toggle mechanism which connects a movable platen and a rear platen; and a tie bar which connects the stationary platen and the rear platen in mold opening and closing directions, characterized in that the toggle mechanism includes a plurality of links (151, 152, 153, 154), a first connection portion which connects the movable platen and the link, a second connection portion which connects the links (152, 153) to each other, and a third connection portion which connects the rear platen and the link, at least one of the first to third connection portions includes a height position changing mechanism which changes a height position of a connection pin of the connection portion, at least one of a bearing portion (60, 60A to 60D) of the movable platen, a bearing portion (60, 60A to 60D) of the rear platen, and a bearing portion (60, 60A to 60D) of the link (151, 152, 153, 154) has a main body-side bearing portion and a division bearing portion which is removable from the main body-side bearing portion, the main body-side bearing portion and the division bearing portion support the connection pin with a gap between the main body-side bearing portion and the division bearing portion, and a height position of the connection pin inserted into the bearing portion interferes with a height position of the tie bar. a stationary platen; a toggle mechanism which connects a movable platen and a rear platen; and a tie bar which connects the stationary platen and the rear platen in mold opening and closing directions, characterized in that the toggle mechanism includes a plurality of links (151, 152, 153, 154), a first connection portion which connects the movable platen and the link, a second connection portion which connects the links (152, 153) to each other, and a third connection portion which connects the rear platen and the link, a plurality of links (151, 152, 153, 154), a first connection portion which connects the movable platen and the link, a second connection portion which connects the links (152, 153) to each other, and a third connection portion which connects the rear platen and the link, at least one of the first to third connection portions includes a height position changing mechanism which changes a height position of a connection pin of the connection portion, at least one of a bearing portion (60, 60A to 60D) of the movable platen, a bearing portion (60, 60A to 60D) of the rear platen, and a bearing portion (60, 60A to 60D) of the link (151, 152, 153, 154) has a main body-side bearing portion and a division bearing portion which is removable from the main body-side bearing portion, the main body-side bearing portion and the division bearing portion support the connection pin with a gap between the main body-side bearing portion and the division bearing portion, and a height position of the connection pin inserted into the bearing portion interferes with a height position of the tie bar.
An armchair comprising an armchair frame having a side support (20A, 20B) on both sides with respect to a vertical longitudinal center plane of the armchair and on which a seat cushion and a backrest are mounted, characterized in that an armrest (28A, 28B) is pivotably mounted on each of the laterally arranged side supports (20A, 20B) via at least one joint, said armrests being adjustable between a lowered rest position and at least one raised position of use.
Method for wear monitoring of a hydraulic clutch of a vehicular driveline (PSH, SSH) comprising in succession (i) a first step of acquiring, at engagement and/or disengagement of the hydraulic clutch, a derivative of a signal representative of a pressure in a corresponding actuation circuit of the hydraulic clutch, (ii) a second step of measurement of a time interval (TH2, TH3, etc..) elapsing between a first instant, corresponding to the activation of the engagement command of the clutch, and a second instant (FS1, FS2, FS3) wherein the derivative of said signal assumes a second divergent trend and (iii) a third step of comparing said time interval (TH2, TH3, etc..) with a predetermined threshold, the method is characterized in that it further comprises a preliminary step of setting as a predetermined threshold said time interval obtained by means of a first preliminary execution of the first and second steps, namely when the clutch is new.
Sub-structure clamping device, in particular for use in bodywork construction in the automotive industry, having a housing, a toggle-lever arrangement located in the housing which can be driven via a rod-shaped adjusting element in opposing directions (X-Y) by a mechanical drive (1, 7) (piston-cylinder unit, or linear motor or electric motor) as required into the dead-centre or upper dead-centre position, and in the opposite direction, into the release position, a clamping element emerging with a longitudinal section from the housing in a lifting movement for clamping components against a rigid support element assigned to the housing, where the toggle-lever arrangement is connected via a gear to a multi-armed lever element arranged in the housing moving around a swivelling axis fixed to the housing, and this lever element with one lever arm is coupled via a travelling swivelling axis by means of a gear to an end section of the clamping element which is located permanently in the housing, characterised in that this swivelling axis is arranged to slide in an oblong hole extending in the longitudinal direction of the end section of the clamping element arranged in the housing, and this lever arm, when in clamping position, presses via a pressure lever (if necessary indirectly) against a spring element the opposite end of which is supported against an extension or other thrust element of the end section of the clamping element located in the housing, or is supported against a thrust element assigned to a shaft extension of the clamping element, e.g. in an interchangeable spring housing (if necessary indirectly) under continuous tension, where the swivelling axis is actuated forcibly with low friction at one end area (preferably at both opposing end areas) in slot-shaped, reniform, or arc-shaped slotted guide systems where these slotted guide systems are assigned to the housing.
A computer-implemented method for calibrating a pose relationship between a vehicle sensor and a vehicle, the method comprising: acquiring, by a field-end sensor pre-deployed in a calibration environment, a first image of the calibration environment, and acquiring a second image of the calibration environment by a vehicle sensor, the field-end sensor being mounted in a side edge area of the calibration environment, different identifier units arranged in a preset mode being laid on a spatial plane of the calibration environment, and each identifier unit corresponding to a feature corner point; determining a first pose transformation relationship between a vehicle coordinate system and a world coordinate system using a first feature corner point identified from the first image and a contact point between the vehicle and ground; determining a second pose transformation relationship between a vehicle sensor coordinate system and the world coordinate system using a second feature corner point identified from the second image; and calibrating the pose relationship between the vehicle sensor and the vehicle using the first pose transformation relationship and the second pose transformation relationship. acquiring, by a field-end sensor pre-deployed in a calibration environment, a first image of the calibration environment, and acquiring a second image of the calibration environment by a vehicle sensor, the field-end sensor being mounted in a side edge area of the calibration environment, different identifier units arranged in a preset mode being laid on a spatial plane of the calibration environment, and each identifier unit corresponding to a feature corner point; determining a first pose transformation relationship between a vehicle coordinate system and a world coordinate system using a first feature corner point identified from the first image and a contact point between the vehicle and ground; determining a second pose transformation relationship between a vehicle sensor coordinate system and the world coordinate system using a second feature corner point identified from the second image; and calibrating the pose relationship between the vehicle sensor and the vehicle using the first pose transformation relationship and the second pose transformation relationship.
Fire protection closure comprising a plurality of layers of elastic fire-resistant material, wherein the fire protection closure has two supporting layers, between which there is an intermediate layer and to which two upper layers adhere from the outside, wherein the supporting layer of fire-resistant material, to which strip-shaped slats of fire-resistant material are attached, each of the slats being attached with one of its longitudinal edges, wherein at least one surface of the slat has a swelling coating of material that becomes thicker after heating, and wherein each slat in the swollen state of its swelling coating inclines transversely away from the supporting layer and rests with its free edge on the surface of the adjacent upper layers or intermediate layer, wherein the slats are arranged opposite one another on both sides of the supporting layers.
System for crystallization of a substance to be crystallized that is solved in a solvent, with a solution to be concentrated, which contains the solvent with the substance to be crystallized solved in it and a crystallization apparatus with hot vapor or hot liquid flowing through it, wherein the crystallization apparatus has at least one flow channel transporting the solution to be concentrated, at least one flow channel transporting the hot vapor or the hot liquid, and at least one flow channel transporting the vaporous solvent, wherein a respective flow channel transporting the solution to be concentrated is at least partially separated by a vapor-proof and liquid- proof wall from a respective flow channel transporting the hot vapor or the hot liquid, and the respective flow channel transporting the solution to be concentrated is separated at least partially by a membrane wall, which is permeable for the vaporous solvent but not for the liquid solvent, from a respective flow channel transporting the vaporous solvent, wherein the crystallization apparatus is so designed that the solution to be concentrated is boiling in the respective flow channel transporting the solution to be concentrated and that the vaporous solvent generated during the boiling reaches through the membrane wall to the adjacent flow channel transporting the vaporous solvent, characterized in that the respective flow channel transporting the solution to be concentrated has a width of at least 3 mm, and a sediment collecting tank below connects to a respective flow channel transporting the solution to be concentrated.
A method for increasing the temperature of a film before and/or during application of the film to a perishable product in a reduced temperature environment, the method comprising: providing a film (102; 202; 302; 402; 502) to at least one roller (104; 204; 304; 404; 504); providing a film preheater system (100; 200) comprising a heat source (112; 212; 300; 400; 500) that is configured to only provide heat to the film (102; 202; 302; 402; 502), wherein the film preheater system (100; 200) is positioned so as to provide heat directly to the film (102; 202; 302; 402; 502) and across a width of the film on the at least one roller (104; 204; 304; 404; 504); warming the film (102; 202; 302; 402; 502) from an ambient temperature of the reduced temperature environment to a temperature from about 2° C to about 40° C above the ambient temperature of the reduced temperature environment; stretching the film (102; 202; 302; 402; 502) on the at least one roller (104; 204; 304; 404; 504); and wrapping the film (102; 202; 302; 402; 502) around the perishable product; wherein the ambient temperature of the reduced temperature environment to which the film is exposed is below 15° C. providing a film (102; 202; 302; 402; 502) to at least one roller (104; 204; 304; 404; 504); providing a film preheater system (100; 200) comprising a heat source (112; 212; 300; 400; 500) that is configured to only provide heat to the film (102; 202; 302; 402; 502), wherein the film preheater system (100; 200) is positioned so as to provide heat directly to the film (102; 202; 302; 402; 502) and across a width of the film on the at least one roller (104; 204; 304; 404; 504); warming the film (102; 202; 302; 402; 502) from an ambient temperature of the reduced temperature environment to a temperature from about 2° C to about 40° C above the ambient temperature of the reduced temperature environment; stretching the film (102; 202; 302; 402; 502) on the at least one roller (104; 204; 304; 404; 504); and wrapping the film (102; 202; 302; 402; 502) around the perishable product; wherein the ambient temperature of the reduced temperature environment to which the film is exposed is below 15° C.
Dispensing device provided with an additive for dispensing a dose of an additive to a liquid that is flowing in a pipe, and this device primarily consists of a headpiece with an inlet and an outlet to connect the device to the pipe, a housing with an opening that connects to the headpiece and is provided with fastening means to fasten the housing to the headpiece with a volume in which the additive is contained, characterised in that the dispensing device is provided with audio means that are blocked by the presence of the additive itself and are unblocked when the additive is entirely or almost entirely consumed whereby the audio means generate sound in the unblocked state in a mechanical way under the influence of the liquid flow and whereby the audio means take on the form of a ram with a head movably connected to a tubular body connected with anchoring means whereby the audio means have a combined specific gravity lower than water and whereby the anchoring means are located in that section of the dispensing device where the additive that is used last is located, where the audio means are blocked by the additive gripping or enclosing the anchoring means until the additive is consumed, and the audio means are unblocked whereby the ram with its head comes up and either touches the wall of a passage that is located outside the volume of the housing that is defined by a first wall in case the head itself produces a mechanical sound or engages with concentric spinning blades that sweep over a fixed toothed ring in case the head is equipped with means to engage them thereby generating a ratchet sound.