A method of manufacturing a two-piece food can, wherein the method comprises: (i) a can body forming process of punching a metal sheet that has a thermoplastic resin coated at least on one side into an approximately circular shape, drawing and ironing the metal sheet such that the resin-coated surface becomes the inner surface, and forming a bottomed cylindrical can body that has the body part and the bottom part formed integrally, (ii) a heating process of heating the can body formed by the above-described process and holding the surface temperature of the can body at the melting temperature of the thermoplastic resin or higher for at least 20 seconds, (iii) a quenching process, after the heating process, of cooling the can body such that the surface temperature of the can body is Y °C or lower at least within X seconds represented by the formula shown below, X second s = T peak ° C − Y ° C / 5 T peak (°C): the highest temperature of the can body surface at the heating process, and Y (°C): the crystallization ending temperature of the thermoplastic resin, (iv) a bead forming process of forming at least one annular uneven bead around its whole circumference of the side surface of the body part of the can body after the heating process and the quenching process, and/or a bottom rim forming process of forming a bottom rim around its whole circumference that projects outwards to the outer peripheral side surface of the bottom part of the can body after the above-described processes, (v) a filling and hermetic sealing process of filling food having chloride ion concentration of 4000 ppm or higher into the can body having the bead(s) and/or the bottom rim formed by the above-described processes and hermetically sealing the can body by mounting a lid part onto the upper end surface of the can body and seaming it. (i) a can body forming process of punching a metal sheet that has a thermoplastic resin coated at least on one side into an approximately circular shape, drawing and ironing the metal sheet such that the resin-coated surface becomes the inner surface, and forming a bottomed cylindrical can body that has the body part and the bottom part formed integrally, (ii) a heating process of heating the can body formed by the above-described process and holding the surface temperature of the can body at the melting temperature of the thermoplastic resin or higher for at least 20 seconds, (iii) a quenching process, after the heating process, of cooling the can body such that the surface temperature of the can body is Y °C or lower at least within X seconds represented by the formula shown below, X second s = T peak ° C − Y ° C / 5 T peak (°C): the highest temperature of the can body surface at the heating process, and Y (°C): the crystallization ending temperature of the thermoplastic resin, T peak (°C): the highest temperature of the can body surface at the heating process, and Y (°C): the crystallization ending temperature of the thermoplastic resin, (iv) a bead forming process of forming at least one annular uneven bead around its whole circumference of the side surface of the body part of the can body after the heating process and the quenching process, and/or a bottom rim forming process of forming a bottom rim around its whole circumference that projects outwards to the outer peripheral side surface of the bottom part of the can body after the above-described processes, (v) a filling and hermetic sealing process of filling food having chloride ion concentration of 4000 ppm or higher into the can body having the bead(s) and/or the bottom rim formed by the above-described processes and hermetically sealing the can body by mounting a lid part onto the upper end surface of the can body and seaming it.