A base station for handling parameter configurations for a communication device to perform an interference cancellation, wherein the base station is either a Node-B, NB, in a Universal Terrestrial Radio Access Network, UTRAN, or an evolved NB, eNB, or a relay in an evolved UTRAN, E-UTRAN, the base station comprising: a storage unit for storing instructions that when executed cause said base station to perform the steps of: determining (302, 802) a subset of parameter configuration sets; transmitting (304, 804) information of the subset of parameter configuration sets to the communication device via a higher layer signaling; selecting (306, 806) at least one parameter configuration set from the subset of parameter configuration sets, wherein at least one parameter configuration of the at least one parameter configuration set corresponds to at least one co-scheduled communication device, respectively; transmitting (308, 808) information of the at least one parameter configuration set to the communication device via a physical layer signalling; transmitting (310, 810) a signal to the communication device via a radio resource, wherein the transmission is performed according to a transmission scheme and a parameter configuration of the communication device; and transmitting (312, 812) at least one signal to the at least one co-scheduled communication device via the radio resource, wherein the transmission is performed according to the transmission scheme and the at least one parameter configuration, and wherein the signal transmitted to the communication device is subject to interference from the at least one signal transmitted to the at least one co-scheduled communication device; wherein the size of each of the at least one parameter configuration set is equal to or greater than one; wherein each parameter configuration of the subset of parameter configuration sets comprises a modulation and coding scheme, called MCS hereinafter, or a precoding matrix index, called PMI hereinafter; wherein the transmission scheme is a non-orthogonal multiple access, called NOMA hereinafter, scheme or a multi-user multi-input multi-output, called MU-MIMO hereinafter, scheme; wherein the information of the at least one parameter configuration set is represented by a bitmap; wherein a length of the bitmap is determined according to a size of the subset of parameter configuration sets; and a processing means, coupled to the storage unit, configured to execute the instructions stored in the storage unit. determining (302, 802) a subset of parameter configuration sets; transmitting (304, 804) information of the subset of parameter configuration sets to the communication device via a higher layer signaling; selecting (306, 806) at least one parameter configuration set from the subset of parameter configuration sets, wherein at least one parameter configuration of the at least one parameter configuration set corresponds to at least one co-scheduled communication device, respectively; transmitting (308, 808) information of the at least one parameter configuration set to the communication device via a physical layer signalling; transmitting (310, 810) a signal to the communication device via a radio resource, wherein the transmission is performed according to a transmission scheme and a parameter configuration of the communication device; and transmitting (312, 812) at least one signal to the at least one co-scheduled communication device via the radio resource, wherein the transmission is performed according to the transmission scheme and the at least one parameter configuration, and wherein the signal transmitted to the communication device is subject to interference from the at least one signal transmitted to the at least one co-scheduled communication device; wherein the size of each of the at least one parameter configuration set is equal to or greater than one; wherein each parameter configuration of the subset of parameter configuration sets comprises a modulation and coding scheme, called MCS hereinafter, or a precoding matrix index, called PMI hereinafter; wherein the transmission scheme is a non-orthogonal multiple access, called NOMA hereinafter, scheme or a multi-user multi-input multi-output, called MU-MIMO hereinafter, scheme; wherein the information of the at least one parameter configuration set is represented by a bitmap; wherein a length of the bitmap is determined according to a size of the subset of parameter configuration sets; and a processing means, coupled to the storage unit, configured to execute the instructions stored in the storage unit.