A computer implemented method, comprising the steps of: receiving one or more patient parameters before the start of a current peritoneal dialysis session, the one or more received patient parameters comprising intersession history, wherein the intersession history comprises patient well-being including whether the patient experienced edema during or after a previous dialysis session; receiving a prior dialysis prescription from a prior peritoneal dialysis session; and storing the one or more received patient parameters before the start of the current peritoneal dialysis session and the prior dialysis prescription into a machine-readable storage medium with stored instructions, which when executed by a dialysis machine perform the steps of: determining a new peritoneal dialysis prescription based on adjustments of the prior peritoneal dialysis prescription based on the one or more received patient parameters before the start of the current peritoneal dialysis session, wherein the step of adjusting the peritoneal dialysis prescription comprises increasing an osmotic agent concentration, increasing a dwell time, and/or increasing a number of cycles if the patient experienced edema during or after the previous dialysis session; and delivering the new peritoneal dialysis prescription for the current peritoneal dialysis therapy to a patient in need thereof. receiving one or more patient parameters before the start of a current peritoneal dialysis session, the one or more received patient parameters comprising intersession history, wherein the intersession history comprises patient well-being including whether the patient experienced edema during or after a previous dialysis session; receiving a prior dialysis prescription from a prior peritoneal dialysis session; and storing the one or more received patient parameters before the start of the current peritoneal dialysis session and the prior dialysis prescription into a machine-readable storage medium with stored instructions, which when executed by a dialysis machine perform the steps of: determining a new peritoneal dialysis prescription based on adjustments of the prior peritoneal dialysis prescription based on the one or more received patient parameters before the start of the current peritoneal dialysis session, wherein the step of adjusting the peritoneal dialysis prescription comprises increasing an osmotic agent concentration, increasing a dwell time, and/or increasing a number of cycles if the patient experienced edema during or after the previous dialysis session; and delivering the new peritoneal dialysis prescription for the current peritoneal dialysis therapy to a patient in need thereof. determining a new peritoneal dialysis prescription based on adjustments of the prior peritoneal dialysis prescription based on the one or more received patient parameters before the start of the current peritoneal dialysis session, wherein the step of adjusting the peritoneal dialysis prescription comprises increasing an osmotic agent concentration, increasing a dwell time, and/or increasing a number of cycles if the patient experienced edema during or after the previous dialysis session; and delivering the new peritoneal dialysis prescription for the current peritoneal dialysis therapy to a patient in need thereof.