A computer-implemented method for distinguishing within at least one set of diagnostic signatures for clinical diagnosis of disease, disease staging and/or therapy choice, determined (S1, 101) from clinical data collected from a group of samples, the signatures being obtained by detecting characteristics in the clinical data from the group of samples, where each of the signatures generates a first set of stratification values that stratify the group of samples, the method comprising: providing at least one additional stratification source, parallel to the signatures obtained from said group of samples (S2, 103), the at least one parallel stratification source being independent from the signatures and generating a second set of stratification values for the group of samples, comparing for each respective sample (S3, 105): the first set of stratification values with true reference stratification values, the second stratification values with said true reference stratification values, assigning the signatures and the parallel stratification source with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values (S4, 107), and using the similarity measure indicators as input in determining an alignment indicator by comparing results from similarity measures between pairs of stratifications of the first and second sets of stratifications (S5, 109), the alignment indicator indicating how aligned the stratification values of the at least one set of signatures are with the stratification values of the at least one parallel stratification source, the alignment indicator being used to distinguish at least one more reliable signature from the at least one set of signatures. providing at least one additional stratification source, parallel to the signatures obtained from said group of samples (S2, 103), the at least one parallel stratification source being independent from the signatures and generating a second set of stratification values for the group of samples, comparing for each respective sample (S3, 105): the first set of stratification values with true reference stratification values, the second stratification values with said true reference stratification values, assigning the signatures and the parallel stratification source with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values (S4, 107), and using the similarity measure indicators as input in determining an alignment indicator by comparing results from similarity measures between pairs of stratifications of the first and second sets of stratifications (S5, 109), the alignment indicator indicating how aligned the stratification values of the at least one set of signatures are with the stratification values of the at least one parallel stratification source, the alignment indicator being used to distinguish at least one more reliable signature from the at least one set of signatures. the first set of stratification values with true reference stratification values, the second stratification values with said true reference stratification values, assigning the signatures and the parallel stratification source with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values (S4, 107), and using the similarity measure indicators as input in determining an alignment indicator by comparing results from similarity measures between pairs of stratifications of the first and second sets of stratifications (S5, 109), the alignment indicator indicating how aligned the stratification values of the at least one set of signatures are with the stratification values of the at least one parallel stratification source, the alignment indicator being used to distinguish at least one more reliable signature from the at least one set of signatures.