An optical fiber comprising: a glass core extending from a centerline to a radius R 1 wherein R 1 is greater than 5 μm; a glass cladding surrounding and in contact with the core, wherein the core and the cladding provide a fiber with cable cutoff less than 1500 nm, an effective area at 1550 nm greater than 110 μm 2 and bend loss of ≤0.7 dB/turn on a 20 mm diameter mandrel and, wherein (i) the cladding comprises: a first annular region extending from the radius R 1 to a radius R 2, the first annular region comprising a radial width, W 2 = R 2 - R 1, a second annular region extending from the radius R 2 to a radius R 3, and comprising a radial width, W 3 = R 3 - R 2, wherein W 3 is between 2μm and 10μm, and a third annular region surrounding the second annular region and extending from the radius R 3 to an outermost glass radius R 4; and (ii) the core comprises a maximum relative refractive index, Δ 1MAX, relative to the third annular region, wherein the first annular region has a refractive index delta Δ 1 (r), with Δ 1 (r), less than 0.025%, a minimum refractive index Δ 2MIN and a maximum refractive index Δ 2MAX; wherein the second annular region comprises: a minimum relative refractive index, Δ 3 MIN, relative to the third annular region; wherein Δ 1MAX > Δ 2MAX, Δ 2MAX > A 3MIN, and A 3MIN <0 and Δ 2MIN > Δ 3MIN. and said second annular region comprises silica based glass with at least 50 closed randomly dispersed holes situated therein, and (i) mean distance between the holes is less than 5000 nm, and (ii) at least 80% of the holes have a maximum cross-sectional dimension Di of less than 1000 nm; characterized in that Δ 1MAX is greater than 0.1 % and less than 0.25 %, R 2 >15 μm, and R 1 /R 2 is between 0.3 and 0.4. a glass core extending from a centerline to a radius R 1 wherein R 1 is greater than 5 μm; a glass cladding surrounding and in contact with the core, wherein the core and the cladding provide a fiber with cable cutoff less than 1500 nm, an effective area at 1550 nm greater than 110 μm 2 and bend loss of ≤0.7 dB/turn on a 20 mm diameter mandrel and, wherein (i) the cladding comprises: a first annular region extending from the radius R 1 to a radius R 2, the first annular region comprising a radial width, W 2 = R 2 - R 1, a second annular region extending from the radius R 2 to a radius R 3, and comprising a radial width, W 3 = R 3 - R 2, wherein W 3 is between 2μm and 10μm, and a third annular region surrounding the second annular region and extending from the radius R 3 to an outermost glass radius R 4; and (ii) the core comprises a maximum relative refractive index, Δ 1MAX, relative to the third annular region, (i) the cladding comprises: a first annular region extending from the radius R 1 to a radius R 2, the first annular region comprising a radial width, W 2 = R 2 - R 1, a second annular region extending from the radius R 2 to a radius R 3, and comprising a radial width, W 3 = R 3 - R 2, wherein W 3 is between 2μm and 10μm, and a third annular region surrounding the second annular region and extending from the radius R 3 to an outermost glass radius R 4; and a first annular region extending from the radius R 1 to a radius R 2, the first annular region comprising a radial width, W 2 = R 2 - R 1, a second annular region extending from the radius R 2 to a radius R 3, and comprising a radial width, W 3 = R 3 - R 2, wherein W 3 is between 2μm and 10μm, and a third annular region surrounding the second annular region and extending from the radius R 3 to an outermost glass radius R 4; and (ii) the core comprises a maximum relative refractive index, Δ 1MAX, relative to the third annular region, wherein the first annular region has a refractive index delta Δ 1 (r), with Δ 1 (r), less than 0.025%, a minimum refractive index Δ 2MIN and a maximum refractive index Δ 2MAX; wherein the second annular region comprises: a minimum relative refractive index, Δ 3 MIN, relative to the third annular region; wherein Δ 1MAX > Δ 2MAX, Δ 2MAX > A 3MIN, and A 3MIN <0 and Δ 2MIN > Δ 3MIN. and said second annular region comprises silica based glass with at least 50 closed randomly dispersed holes situated therein, and (i) mean distance between the holes is less than 5000 nm, and (ii) at least 80% of the holes have a maximum cross-sectional dimension Di of less than 1000 nm;