A computer-implemented method for identifying somatic variants in a plurality of variants, comprising: (a) obtaining sequence data corresponding to a plurality of variants comprising somatic variants and germline variants; (b) using a computer processor to apply a database filter to the sequence data of the plurality of variants, comprising: determining first germline variants in the plurality of variants, wherein the first germline variants each have an allele count in a first reference set of variants greater than or equal to a threshold allele count, wherein the threshold allele count is 5, or wherein the threshold allele count is 10; (c) applying a proximity filter to the plurality of variants, comprising: (i) binning variants of the plurality of variants into a plurality of bins, wherein variants located in the same region of a genome are binned into the same bin, (ii) determining variants that are present in a second reference set of variants, and (iii) determining second germline variants in the plurality of variants, wherein the second germline variants each have an allele frequency within a proximate range of an allele frequency of at least one database variant in the same bin as the second germline variant; and (d) determining somatic variants in the plurality of variants by removing the identified first and second germline variants from the plurality of variants. (a) obtaining sequence data corresponding to a plurality of variants comprising somatic variants and germline variants; (b) using a computer processor to apply a database filter to the sequence data of the plurality of variants, comprising: determining first germline variants in the plurality of variants, wherein the first germline variants each have an allele count in a first reference set of variants greater than or equal to a threshold allele count, wherein the threshold allele count is 5, or wherein the threshold allele count is 10; (c) applying a proximity filter to the plurality of variants, comprising: (i) binning variants of the plurality of variants into a plurality of bins, wherein variants located in the same region of a genome are binned into the same bin, (ii) determining variants that are present in a second reference set of variants, and (iii) determining second germline variants in the plurality of variants, wherein the second germline variants each have an allele frequency within a proximate range of an allele frequency of at least one database variant in the same bin as the second germline variant; and (i) binning variants of the plurality of variants into a plurality of bins, wherein variants located in the same region of a genome are binned into the same bin, (ii) determining variants that are present in a second reference set of variants, and (iii) determining second germline variants in the plurality of variants, wherein the second germline variants each have an allele frequency within a proximate range of an allele frequency of at least one database variant in the same bin as the second germline variant; and (d) determining somatic variants in the plurality of variants by removing the identified first and second germline variants from the plurality of variants.