An on-body device, comprising: a glucose sensor assembly (3702, 4702) comprising: a proximal section comprising a connector support (3604, 4706) coupled with a proximal portion of a glucose sensor (3300, 4704); a distal tail section comprising a distal portion of the glucose sensor (3300, 4704) configured to be positioned under a skin surface and in contact with a bodily fluid of a subject; an enclosure comprising: a top portion; and a base portion configured to be adhered to the skin surface of the subject by an adhesive patch (3802, 5104); and sensor electronics positioned within the enclosure, the sensor electronics comprising a processor, and a communications facility, wherein the base portion of the enclosure comprises a recess (3704, 4710) in a bottom exterior surface, the recess (3704, 4710) comprising a distal-facing opening, wherein the connector support (3604, 4706) is received through the distal-facing opening and into the recess (3704, 4710), and wherein the glucose sensor (3300, 4704) is electrically coupled with the sensor electronics by the connector support when the connector support is received into the recess (3704, 4710). a glucose sensor assembly (3702, 4702) comprising: a proximal section comprising a connector support (3604, 4706) coupled with a proximal portion of a glucose sensor (3300, 4704); a distal tail section comprising a distal portion of the glucose sensor (3300, 4704) configured to be positioned under a skin surface and in contact with a bodily fluid of a subject; a proximal section comprising a connector support (3604, 4706) coupled with a proximal portion of a glucose sensor (3300, 4704); a distal tail section comprising a distal portion of the glucose sensor (3300, 4704) configured to be positioned under a skin surface and in contact with a bodily fluid of a subject; an enclosure comprising: a top portion; and a base portion configured to be adhered to the skin surface of the subject by an adhesive patch (3802, 5104); and a top portion; and a base portion configured to be adhered to the skin surface of the subject by an adhesive patch (3802, 5104); and sensor electronics positioned within the enclosure, the sensor electronics comprising a processor, and a communications facility, wherein the base portion of the enclosure comprises a recess (3704, 4710) in a bottom exterior surface, the recess (3704, 4710) comprising a distal-facing opening, wherein the connector support (3604, 4706) is received through the distal-facing opening and into the recess (3704, 4710), and wherein the glucose sensor (3300, 4704) is electrically coupled with the sensor electronics by the connector support when the connector support is received into the recess (3704, 4710). wherein the base portion of the enclosure comprises a recess (3704, 4710) in a bottom exterior surface, the recess (3704, 4710) comprising a distal-facing opening, wherein the connector support (3604, 4706) is received through the distal-facing opening and into the recess (3704, 4710), and wherein the glucose sensor (3300, 4704) is electrically coupled with the sensor electronics by the connector support when the connector support is received into the recess (3704, 4710).