A compound of Formula: wherein R 1 is -NR 3a R 3, -NR 4 C R 4a, heteroaryl, -CH 2 NH 2, -CH 2 CH 2 NH 2, -CH 2 NH 3 +, -CH 2 CH 2 NH 3 +, -NR 5 S 2 R 5a, -NR 6 C NR 6a R 6b, or -NR 8 C OR 8a; R 2 is -NR 7 C R 7a; R 3 is hydrogen or C 1-6 alkyl; R 3a is hydrogen or C 1-6 alkyl; R 4 is hydrogen or C 1-6 alkyl; R 4a is hydrogen; C 1-6 alkyl; halo-C 1-6 alkyl; amino-C 1-6 alkyl; C 1-6 alkylaminoC 1-6 alkyl; di-C 1-6 alkylaminoC 1-6 alkyl; C 1-6 alkoxyC 1-6 alkyl; cycloalkyl; cycloalkylalkyl; aryl optionally substituted with 1,2, 3, or 4 R 4b groups; aralkyl where the aryl portion is optionally substituted with 1, 2, 3, or 4 R 4b groups; heterocycloalkyl optionally substituted with 1, 2, 3, or 4 R 4b groups; heteroaryl optionally substituted with 1, 2, 3, or 4 R 4b groups;-heteroaralkyl where the heteroaryl portion is optionally substituted with 1, 2, 3, or 4 R 4b groups; heterocyclic optionally substituted with 1, 2, 3, or 4 R 4b groups; or heterocyclicalkyl optionally substituted with 1, 2, 3, or 4 R 4b groups; each R 4b, when present, is independently C 1-6 alkyl, hydroxy, halo, halo-C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 1-6 alkoxy, cyano, phenyl, or -O-(C 1-6 alkylene)-OZ, wherein Z is hydrogen or wherein Y is hydrogen or Boc group, and represents the point of attachment; R 5 is hydrogen or C 1-6 alkyl; R 5a is heterocycloalkyl, amino, C 1-6 alkylamino, or di- C 1-6 alkylamino; R 6 is hydrogen or C 1-6 alkyl; R 6a is hydrogen, or C 1-6 alkyl; R 6b is hydrogen, C 1-6 alkyl, C 1-6 alkoxy or cycloalkyl; R 8 is hydrogen or C 1-6 alkyl; R 8a is hydrogen, C 1-6 alkyl, cycloalkyl or phenyl; R 7 is hydrogen; R 7a is and each R 7b, when present, is independently halo, C 1-6 alkyl, halo-C 1-6 alkyl, hydroxy, C 1-6 alkoxy, halo-C 1-6 alkoxy, nitro, C 1-6 alkylthio, halo-C 1-6 alkylthio, C 1-6 alkylsulfinyl, halo-C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, halo-C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, or cyano; or a) one R 7b is methyl or ethyl and the other R 7b is hydrogen or b) the two R 7b are both hydrogen; or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, mixture of stereoisomers, tautomer, or combinations thereof. R 1 is -NR 3a R 3, -NR 4 C R 4a, heteroaryl, -CH 2 NH 2, -CH 2 CH 2 NH 2, -CH 2 NH 3 +, -CH 2 CH 2 NH 3 +, -NR 5 S 2 R 5a, -NR 6 C NR 6a R 6b, or -NR 8 C OR 8a; R 2 is -NR 7 C R 7a; R 3 is hydrogen or C 1-6 alkyl; R 3a is hydrogen or C 1-6 alkyl; R 4 is hydrogen or C 1-6 alkyl; R 4a is hydrogen; C 1-6 alkyl; halo-C 1-6 alkyl; amino-C 1-6 alkyl; C 1-6 alkylaminoC 1-6 alkyl; di-C 1-6 alkylaminoC 1-6 alkyl; C 1-6 alkoxyC 1-6 alkyl; cycloalkyl; cycloalkylalkyl; aryl optionally substituted with 1,2, 3, or 4 R 4b groups; aralkyl where the aryl portion is optionally substituted with 1, 2, 3, or 4 R 4b groups; heterocycloalkyl optionally substituted with 1, 2, 3, or 4 R 4b groups; heteroaryl optionally substituted with 1, 2, 3, or 4 R 4b groups;-heteroaralkyl where the heteroaryl portion is optionally substituted with 1, 2, 3, or 4 R 4b groups; heterocyclic optionally substituted with 1, 2, 3, or 4 R 4b groups; or heterocyclicalkyl optionally substituted with 1, 2, 3, or 4 R 4b groups; each R 4b, when present, is independently C 1-6 alkyl, hydroxy, halo, halo-C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 1-6 alkoxy, cyano, phenyl, or -O-(C 1-6 alkylene)-OZ, wherein Z is hydrogen or wherein Y is hydrogen or Boc group, and represents the point of attachment; R 5 is hydrogen or C 1-6 alkyl; R 5a is heterocycloalkyl, amino, C 1-6 alkylamino, or di- C 1-6 alkylamino; R 6 is hydrogen or C 1-6 alkyl; R 6a is hydrogen, or C 1-6 alkyl; R 6b is hydrogen, C 1-6 alkyl, C 1-6 alkoxy or cycloalkyl; R 8 is hydrogen or C 1-6 alkyl; R 8a is hydrogen, C 1-6 alkyl, cycloalkyl or phenyl; R 7 is hydrogen; R 7a is and each R 7b, when present, is independently halo, C 1-6 alkyl, halo-C 1-6 alkyl, hydroxy, C 1-6 alkoxy, halo-C 1-6 alkoxy, nitro, C 1-6 alkylthio, halo-C 1-6 alkylthio, C 1-6 alkylsulfinyl, halo-C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, halo-C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, or cyano; or a) one R 7b is methyl or ethyl and the other R 7b is hydrogen or b) the two R 7b are both hydrogen; or halo-C 1-6 alkoxy, nitro, C 1-6 alkylthio, halo-C 1-6 alkylthio, C 1-6 alkylsulfinyl, halo-C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, halo-C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di-C 1-6 alkylamino, or cyano; or a) one R 7b is methyl or ethyl and the other R 7b is hydrogen or b) the two R 7b are both hydrogen; or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, mixture of stereoisomers, tautomer, or combinations thereof.