Method to manufacture a component suitable to be installed inside a protected chamber of a machine for the production and/or packaging of pharmaceutical products, wherein said chamber is a controlled atmosphere chamber, separated from the external environment in a sealed manner, and configured to receive one or more pieces of equipment, or devices, or elements, each formed by one or more of said components, wherein the interior of said chamber, that is to say, said components that form the equipment, or the devices, or the elements, is/are intended to be subjected to suitable decontamination and sterilization treatments, for example CIP (Clean-In-Place) treatments and/or SIP (Sterilizing-In-Place) treatments, which provide to use hydrogen peroxide vapors (VPHP, Vapor Phase Hydrogen Peroxide), said method being characterized in that it comprises the steps of: - making available a component made of a first material chosen from a group comprising aluminum (Al), magnesium (Mg), titanium (Ti), steel, or their alloys, composite materials with a polymer matrix, carbon fibers, or combinations thereof, wherein said component is intended to be installed inside said chamber, and is provided with at least one coupling portion configured to be coupled with a corresponding and mating coupling portion provided on another component or on an internal wall of the chamber, and comprises at least one external surface which, in an assembled and installed condition of the component, faces toward the outside, that is, being directly exposed to the atmosphere of the chamber; - before assembling or installing the component in said chamber, that is, before its coupling portion is stably joined to the corresponding mating coupling portion or to internal walls of the chamber, subjecting said component to a thermal spray treatment using solid powders of a second material, accelerated in a supersonic gaseous jet, wherein said second material is chosen from a group comprising one or more of either stainless steel, cobalt-chromium metal alloy, nickel alloy, a material with a polymer matrix, a metal-ceramic composite material, in order to deposit a coating of said second material at least on said external surface to make it suitable to withstand said decontamination or sterilization treatments. - making available a component made of a first material chosen from a group comprising aluminum (Al), magnesium (Mg), titanium (Ti), steel, or their alloys, composite materials with a polymer matrix, carbon fibers, or combinations thereof, wherein said component is intended to be installed inside said chamber, and is provided with at least one coupling portion configured to be coupled with a corresponding and mating coupling portion provided on another component or on an internal wall of the chamber, and comprises at least one external surface which, in an assembled and installed condition of the component, faces toward the outside, that is, being directly exposed to the atmosphere of the chamber; - before assembling or installing the component in said chamber, that is, before its coupling portion is stably joined to the corresponding mating coupling portion or to internal walls of the chamber, subjecting said component to a thermal spray treatment using solid powders of a second material, accelerated in a supersonic gaseous jet, wherein said second material is chosen from a group comprising one or more of either stainless steel, cobalt-chromium metal alloy, nickel alloy, a material with a polymer matrix, a metal-ceramic composite material, in order to deposit a coating of said second material at least on said external surface to make it suitable to withstand said decontamination or sterilization treatments.