mhurhangee/ep-ind-claims huggingface dataset:
A roughing end mill comprising: a plurality of cutting edges that are undulated in wave forms in a direction of an axis and are formed on an outer periphery of a front end portion of an end mill body rotating about the axis so that phases of the wave forms are displaced from each other in a path of rotation about the axis, wherein flank faces of the cutting edges are covered with a coating film, characterized in that rough surface regions and smooth surface regions are alternately formed on the surface of at least portions of the coating film, which are close to the cutting edges, in the direction of the axis, and the number per unit area of fine particles or fine protrusions, which have a size in the range of 0.3 μm to 5.0 μm and protrude from the rough surface region, is larger than the number per unit area of fine particles or fine protrusions, which have a size in the range of 0.3 μm to 5.0 μm and protrude from the smooth surface region. a plurality of cutting edges that are undulated in wave forms in a direction of an axis and are formed on an outer periphery of a front end portion of an end mill body rotating about the axis so that phases of the wave forms are displaced from each other in a path of rotation about the axis, wherein flank faces of the cutting edges are covered with a coating film, characterized in that rough surface regions and smooth surface regions are alternately formed on the surface of at least portions of the coating film, which are close to the cutting edges, in the direction of the axis, and the number per unit area of fine particles or fine protrusions, which have a size in the range of 0.3 μm to 5.0 μm and protrude from the rough surface region, is larger than the number per unit area of fine particles or fine protrusions, which have a size in the range of 0.3 μm to 5.0 μm and protrude from the smooth surface region.
A use of a sanitary napkin for preventing irritation, pressure points and wounds, which is attached in the crotch and placed on the inside of the upper thigh with leg cuffs, wherein the leg cuffs are elastically stretched by moving the legs and the sanitary napkin comprises: • a liquid-absorbing core, • a rear covering of the core, • a liquid-permeable front covering of the core and elastic film strips (9, 10) on the two longitudinal sides (5, 6) of the core that are connected in the stretched state along their longitudinal direction to at least one of the aforementioned components and contract in the relaxed state, wherein • the elastic film strips (9, 10) are activated film strips that have obtained their elasticity after an overstretching before their connection to the at least one component, and • the force/elongation curve of the elastic film strips (9, 10) has a hysteresis at which the leg cuffs quickly yield to a load but only gradually assume their original position again in that, when the leg cuffs stretch, they pass through a first path of a hysteresis curve that describes the dependency between force and stretching of the leg cuffs and, upon relaxing, follow a second path of the hysteresis curve, wherein, on the first path, the stretching of the leg cuffs at a specific load is smaller than at the same load on the second path. • a liquid-absorbing core, • a rear covering of the core, • a liquid-permeable front covering of the core and elastic film strips (9, 10) on the two longitudinal sides (5, 6) of the core that are connected in the stretched state along their longitudinal direction to at least one of the aforementioned components and contract in the relaxed state, • the elastic film strips (9, 10) are activated film strips that have obtained their elasticity after an overstretching before their connection to the at least one component, and • the force/elongation curve of the elastic film strips (9, 10) has a hysteresis at which the leg cuffs quickly yield to a load but only gradually assume their original position again in that, when the leg cuffs stretch, they pass through a first path of a hysteresis curve that describes the dependency between force and stretching of the leg cuffs and, upon relaxing, follow a second path of the hysteresis curve, wherein, on the first path, the stretching of the leg cuffs at a specific load is smaller than at the same load on the second path.
A multispecific antibody or fragment thereof that specifically binds: a. a first target epitope, wherein the first target epitope is an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor; and b. a second target epitope, wherein the second epitope is selected from the group consisting of an epitope of CD19, Her2, EGFR, FAPα, mesothelin, PD-1, 4-1 BB, OX40 and TIGIT. a. a first target epitope, wherein the first target epitope is an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor; and b. a second target epitope, wherein the second epitope is selected from the group consisting of an epitope of CD19, Her2, EGFR, FAPα, mesothelin, PD-1, 4-1 BB, OX40 and TIGIT.
Support for carrying a sensor system like a thermal imaging system, the support being adapted to be detachably connected to a headpiece, in particular a helmet like a fireman's helmet, the support comprising: a securing unit adapted to be fastened to the headpiece, the securing unit comprising means for detachably fastening the securing unit to the headpiece, in particular without modifying the headpiece; a base unit connected to the securing unit or being part of the same; arms (6, 7) comprising first ends (61, 71) and second ends (62, 72) and extending laterally from the base unit in a generally u-shaped form so that the second ends (62, 72) are positioned around a wearer's ears characterized in that the arms (6, 7) comprise a mounting adapter (63, 73) for pivotably mounting components (13, 14) of the sensor system. a securing unit adapted to be fastened to the headpiece, the securing unit comprising means for detachably fastening the securing unit to the headpiece, in particular without modifying the headpiece; a base unit connected to the securing unit or being part of the same; arms (6, 7) comprising first ends (61, 71) and second ends (62, 72) and extending laterally from the base unit in a generally u-shaped form so that the second ends (62, 72) are positioned around a wearer's ears characterized in that the arms (6, 7) comprise a mounting adapter (63, 73) for pivotably mounting components (13, 14) of the sensor system.
A compound that is 3-([[(4 R)-7-[methyl[4-propan-2-yl)phenyl]amino]-3,4-dihydro-2H-1-benzopyran-4-yl]methyl]amino)pyridine-4-carboxylic acid, represented by the structure: or a pharmaceutically acceptable salt thereof, for use in a method of treating a cancer associated with lysine demethylase 4 activity (a KDM4-associated cancer), the method comprising administering to a patient in need thereof a pharmaceutical composition comprising the compound or salt, and a pharmaceutically acceptable excipient, wherein the KDM4-associated cancer is selected from triple-negative breast cancer, colon cancer, Burkitt's lymphoma, or acute myeloid leukemia. or a pharmaceutically acceptable salt thereof, for use in a method of treating a cancer associated with lysine demethylase 4 activity (a KDM4-associated cancer), the method comprising administering to a patient in need thereof a pharmaceutical composition comprising the compound or salt, and a pharmaceutically acceptable excipient, wherein the KDM4-associated cancer is selected from triple-negative breast cancer, colon cancer, Burkitt's lymphoma, or acute myeloid leukemia.
An adapter (10; 40; 50; 60; 70; 100; 101; 102; 103; 104; 105; 106) for a medical device, the medical device being a catheter, said adapter (10; 50; 100; 101; 105) comprising: a proximal portion and a distal portion; and an attachment mechanism positioned at the proximal portion of the adapter (10; 50; 100; 101; 105), said attachment mechanism adapted to couple said adapter (10; 50; 100; 101; 105) to a distal end of an inner lumen of the medical device, wherein the distal portion of the adapter (10; 50; 100; 101; 105) extends beyond the distal end of the inner lumen of the medical device, characterised in that the attachment mechanism comprises a coil (12; 130; 257; 264) and a tube co-axial with the coil (12; 130; 257; 264), wherein the coil (12; 130; 257; 264) comprises a wire, a portion of the coil (12; 130; 257; 264) is attached to a portion of the tube and a portion of the coil (12; 130; 257; 264) interfaces with a portion of the inner lumen of the medical device, and the tube is coupled to the distal portion of the adapter (10; 50; 100; 101; 105), and wherein said attachment mechanism is adapted to be coupled to said medical device by an interference fit of said coil (12; 130; 257; 264) with said inner lumen. a proximal portion and a distal portion; and an attachment mechanism positioned at the proximal portion of the adapter (10; 50; 100; 101; 105), said attachment mechanism adapted to couple said adapter (10; 50; 100; 101; 105) to a distal end of an inner lumen of the medical device, wherein the distal portion of the adapter (10; 50; 100; 101; 105) extends beyond the distal end of the inner lumen of the medical device, characterised in that the attachment mechanism comprises a coil (12; 130; 257; 264) and a tube co-axial with the coil (12; 130; 257; 264), wherein the coil (12; 130; 257; 264) comprises a wire, a portion of the coil (12; 130; 257; 264) is attached to a portion of the tube and a portion of the coil (12; 130; 257; 264) interfaces with a portion of the inner lumen of the medical device, and the tube is coupled to the distal portion of the adapter (10; 50; 100; 101; 105), and wherein said attachment mechanism is adapted to be coupled to said medical device by an interference fit of said coil (12; 130; 257; 264) with said inner lumen.
A lancet (20, 50, 120, 220) to be attached to a main body portion including a biasing member configured to cause a tip of a puncture needle (21, 221) to protrude in a predetermined puncturing direction, comprising: a puncture body (23, 123, 223) including a puncture needle (21, 221) and a connection portion (23d, 123d) which is formed on an end opposite to the puncture needle (21, 221) and is to be connected to the main body portion; a case portion (22, 122, 222) including a tubular portion (22a, 122a, 222a) which accommodates the puncture body (23, 123, 223) so as to be movable back and forth in the puncturing direction, and an opening formed on a front end of the tubular portion at which the puncture needle (21, 221) is caused to protrude; a first fitting portion (22b, 23c, 23g, 222b, 223c) configured to hold the puncture body (23, 123, 223) in the case portion (22, 122, 222) so as to be immovable back and forth in the puncturing direction when the connection portion (23d, 123d) of the puncture body (23, 123, 223) is separated from the main body portion, characterized in that the lancet further comprises a second fitting portion (22c, 24a, 222c, 224a) configured to hold the puncture body (23, 123, 223) in the case portion so as to be immovable back and forth in the puncturing direction before use, wherein the second fitting portion (22c, 24a, 222c, 224a) is formed by combining a convex portion and a recessed portion formed on a cap portion (24, 224) attached to a front end side of the puncture body (23, 123, 223) so as to cover a tip of the puncture needle (21, 221) and an inner surface of the tubular portion (22a, 122a, 222a). a puncture body (23, 123, 223) including a puncture needle (21, 221) and a connection portion (23d, 123d) which is formed on an end opposite to the puncture needle (21, 221) and is to be connected to the main body portion; a case portion (22, 122, 222) including a tubular portion (22a, 122a, 222a) which accommodates the puncture body (23, 123, 223) so as to be movable back and forth in the puncturing direction, and an opening formed on a front end of the tubular portion at which the puncture needle (21, 221) is caused to protrude; a first fitting portion (22b, 23c, 23g, 222b, 223c) configured to hold the puncture body (23, 123, 223) in the case portion (22, 122, 222) so as to be immovable back and forth in the puncturing direction when the connection portion (23d, 123d) of the puncture body (23, 123, 223) is separated from the main body portion, characterized in that the lancet further comprises a second fitting portion (22c, 24a, 222c, 224a) configured to hold the puncture body (23, 123, 223) in the case portion so as to be immovable back and forth in the puncturing direction before use, wherein the second fitting portion (22c, 24a, 222c, 224a) is formed by combining a convex portion and a recessed portion formed on a cap portion (24, 224) attached to a front end side of the puncture body (23, 123, 223) so as to cover a tip of the puncture needle (21, 221) and an inner surface of the tubular portion (22a, 122a, 222a).
Polycrystalline material comprising grains of cubic boron nitride, silicon nitride or diamond, grains of carbide material, a plurality of nano-grains of a crystalline phase of an iron group element and a plurality of crystalline grains of material including carbon or nitrogen; the iron group element being iron, the polycrystalline material further comprising at least 1 weight per cent Si, at least 5 weight per cent Cr and at least 40 weight per cent W, the balance of the polycrystalline material consisting essentially of the iron group metal and carbon, each nano-grain comprising any of austenite and ferrite, and having a mean size less than 10 nanometres; the density of the polycrystalline material being at least 98 per cent of the maximum theoretical value, the polycrystalline material comprising a contiguous aggregation of the nano-grains embedded in a binder matrix comprising a crystalline phase, the nano-grains comprised in the aggregation having respective grain boundaries between them.
Filter element with a preferably multilayer structure of a pleated filter medium with a plurality of individual filter pleats (5, 7), wherein, due to an alternating sequence of filter pleats with a first pleat height and filter pleats with a second pleat height, a more effective filter surface is available than with filter pleats with a uniform pleat height, with the result that, when a fluid to be filtered flows through said filter element, there is a lower surface load overall for the filter medium and a lower passage speed of the fluid during filtration, with the consequence that static loading of the filter medium is reduced during operation of the filter, and wherein the pleated filter medium is designed to be tubular in shape, characterised in that the straight portions of the filter pleats (5, 7) each run in a plane in which a middle longitudinal axis of the filter medium also lies and in that the second pleat height is 85% to 95%, preferably 90%, of the first pleat height.
A contraceptive kit comprising one or more packaging units wherein each packaging unit comprises 21 to 28 daily active dosage units and wherein (a) the amount of drospirenone in each daily active dosage unit is at least 2 mg, without any estrogen, and (b) each daily active dosage unit consists of a contraceptive composition suitable for oral administration which comprises drospirenone, wherein drospirenone has a d50 particle size ranging from 10 μm to 60 μm, such that: (i) no more than 50% of the drospirenone initially present in the said daily active dosage unit is dissolved within 30 minutes and (ii) at least 50% of the said drospirenone is dissolved in a time range from 3 hours to 4 hours, when the daily active dosage unit is subjected to an in vitro dissolution test according to the USP XXIII Paddle Method, the percentages of drospirenone being related to the amount of drospirenone initially present in the said daily active dosage unit (a) the amount of drospirenone in each daily active dosage unit is at least 2 mg, without any estrogen, and (b) each daily active dosage unit consists of a contraceptive composition suitable for oral administration which comprises drospirenone, wherein drospirenone has a d50 particle size ranging from 10 μm to 60 μm, such that: (i) no more than 50% of the drospirenone initially present in the said daily active dosage unit is dissolved within 30 minutes and (ii) at least 50% of the said drospirenone is dissolved in a time range from 3 hours to 4 hours, when the daily active dosage unit is subjected to an in vitro dissolution test according to the USP XXIII Paddle Method, the percentages of drospirenone being related to the amount of drospirenone initially present in the said daily active dosage unit (i) no more than 50% of the drospirenone initially present in the said daily active dosage unit is dissolved within 30 minutes and (ii) at least 50% of the said drospirenone is dissolved in a time range from 3 hours to 4 hours,
A method for evaluating immunogenicity of a test substance, the method comprising the steps of: (a) culturing a blood-derived cell population with a test substance, wherein the blood-derived cell population comprises antigen-presenting cells (APCs) and CD4 + T cells and does not substantially comprise CD8 + T cells nor CD25 + T cells; (b) detecting IL-2-secreting T cells in the cell population cultured in step (a) at a time point during the early stage of IL-2 secretion, wherein the time point during the early stage of IL-2 secretion is before proliferation of the T cells becomes active; and (c) calculating the proportion of the IL-2-secreting T cells detected in step (b). (a) culturing a blood-derived cell population with a test substance, wherein the blood-derived cell population comprises antigen-presenting cells (APCs) and CD4 + T cells and does not substantially comprise CD8 + T cells nor CD25 + T cells; (b) detecting IL-2-secreting T cells in the cell population cultured in step (a) at a time point during the early stage of IL-2 secretion, wherein the time point during the early stage of IL-2 secretion is before proliferation of the T cells becomes active; and (c) calculating the proportion of the IL-2-secreting T cells detected in step (b).
A composition comprising a solution of platelet derived growth factor (PDGF) and a biocompatible matrix, wherein the biocompatible matrix comprises particles of porous β-tricalcium phosphate, wherein the biocompatible matrix has a porosity greater than 50%, and further wherein the PDGF is present in the solution at a concentration ranging from 0.1 mg/mL to 1.0 mg/mL and the solution is incorporated in the biocompatible matrix, for use in fusing bones in a joint in an arthrodetic procedure.
Actuator unit comprising - a piezoactuator having a first end face and a second end face, - a sleeve for receiving the piezoactuator, the sleeve having a first end face and a second end face, formed differently from the first end face, - a casting compound, which surrounds the piezoactuator, the piezoactuator and the casting compound having been introduced into the sleeve, and the casting compound reaching up to flush with the first end face of the piezoactuator and the first end face of the sleeve, - two connection elements, which consist in each case of a first partial region and a second partial region, directly adjoining the first partial region, the complete respective second partial region of the connection elements protruding out of the first end face of the piezoactuator and being free of casting compound, - the first end face of the sleeve having an opening, which is suitable for introducing the piezoactuator into the sleeve, - the second end face of the sleeve having an aperture, and the second end face of the piezoactuator being inserted in the aperture, - the complete respective first partial region of the two connection elements being surrounded by the casting compound. - a piezoactuator having a first end face and a second end face, - a sleeve for receiving the piezoactuator, the sleeve having a first end face and a second end face, formed differently from the first end face, - a casting compound, which surrounds the piezoactuator, the piezoactuator and the casting compound having been introduced into the sleeve, and the casting compound reaching up to flush with the first end face of the piezoactuator and the first end face of the sleeve, - two connection elements, which consist in each case of a first partial region and a second partial region, directly adjoining the first partial region, the complete respective second partial region of the connection elements protruding out of the first end face of the piezoactuator and being free of casting compound, - the first end face of the sleeve having an opening, which is suitable for introducing the piezoactuator into the sleeve, - the second end face of the sleeve having an aperture, and the second end face of the piezoactuator being inserted in the aperture, - the complete respective first partial region of the two connection elements being surrounded by the casting compound.
Protection method for protecting an electrical generator or power station unit connected to a power distribution network or to a power transmission line, wherein, in the method, - a short circuit near the generator in the power distribution network or on the power transmission line is detected, and a short-circuit detection signal is generated, when a set of predetermined trigger conditions (B1-B4) is satisfied, and - the generator is disconnected from the power distribution network or the power transmission line if, after generation of the short-circuit detection signal, the trigger conditions (B1-B4) are satisfied at the instant when a predetermined delay time (Tva) elapses, characterized in that - the delay time (Tva) is a variable duration which is reestablished regularly or irregularly before it elapses, as a function of the operating profile after the short-circuit occurrence, the delay time (Tva) is established as a function of the respective power difference between the power before detection of the short circuit and the power at the respective current instant; and - the generator is disconnected from the power distribution network or the power transmission line if the trigger conditions (B1-B4) are satisfied at the instant when the respectively currently established delay time (Tva) elapses. - a short circuit near the generator in the power distribution network or on the power transmission line is detected, and a short-circuit detection signal is generated, when a set of predetermined trigger conditions (B1-B4) is satisfied, and - the generator is disconnected from the power distribution network or the power transmission line if, after generation of the short-circuit detection signal, the trigger conditions (B1-B4) are satisfied at the instant when a predetermined delay time (Tva) elapses, - the delay time (Tva) is a variable duration which is reestablished regularly or irregularly before it elapses, as a function of the operating profile after the short-circuit occurrence, the delay time (Tva) is established as a function of the respective power difference between the power before detection of the short circuit and the power at the respective current instant; and - the generator is disconnected from the power distribution network or the power transmission line if the trigger conditions (B1-B4) are satisfied at the instant when the respectively currently established delay time (Tva) elapses.