Compound of formula or a stereoisomer, a solvate or a pharmaceutically acceptable salt, or an isotope-substituted form thereof: wherein, R x is selected from amino, R b is selected from methyl, halomethyl, -YR a; R a is selected from methyl and cyclopropyl; Y is selected from NH or O; Rv and Rw are independently selected from the group consisting of H, halogen, and methyl; R 1 is selected from H, F, and CH 3; R 2 is selected from H, F, and CH 3; R 3 is H; or, R 1 and R 2 are both CH 2 and linked to form three-membered ring; or, R 2 is CH 2, R 3 is H, and linked to form three-membered ring; A is O or S; R 6 and R 7 are linked to form heterocyclic ring or substituted heterocyclic ring; said heterocyclic ring and substituted heterocyclic ring are a 4 to 6 membered ring, the heterocyclic ring or substituted heterocyclic ring formed by R 6 and R 7 is selected from substituted or unsubstituted bridged ring, substituted or unsubstituted fused ring, and substituted or unsubstituted parallel ring, wherein X is CH 2, NH, O, S, or SO 2; each of m, n, and s is independently selected from an integer of 1 to 5; each of R c, R d, and R e is independently selected from the group consisting of H, halogen, cyano, carboxyl, nitro, alkyl, substituted alkyl, alkoxyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, bridged ring, fused ring and parallel ring; R f and R g are halogen; each of the substituents in said bridged ring, fused ring or parallel ring is independently selected from Boc group, fluorinated C 1-6 alkyl, substituted or unsubstituted heterocyclyl, and alkanoyl, preferably selected from Boc group, fluoromethyl, and - COCH 3; each of the substituents in said R c, R d, and R e is independently selected from the group consisting of halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, C 1-6 alkoxyl, halogenated C 1-6 alkoxyl and hydroxyl. wherein, R x is selected from amino, R b is selected from methyl, halomethyl, -YR a; R a is selected from methyl and cyclopropyl; Y is selected from NH or O; Rv and Rw are independently selected from the group consisting of H, halogen, and methyl; R 1 is selected from H, F, and CH 3; R 2 is selected from H, F, and CH 3; R 3 is H; or, R 1 and R 2 are both CH 2 and linked to form three-membered ring; or, R 2 is CH 2, R 3 is H, and linked to form three-membered ring; A is O or S; R 6 and R 7 are linked to form heterocyclic ring or substituted heterocyclic ring; said heterocyclic ring and substituted heterocyclic ring are a 4 to 6 membered ring, the heterocyclic ring or substituted heterocyclic ring formed by R 6 and R 7 is selected from substituted or unsubstituted bridged ring, substituted or unsubstituted fused ring, and substituted or unsubstituted parallel ring, wherein X is CH 2, NH, O, S, or SO 2; each of m, n, and s is independently selected from an integer of 1 to 5; each of R c, R d, and R e is independently selected from the group consisting of H, halogen, cyano, carboxyl, nitro, alkyl, substituted alkyl, alkoxyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, bridged ring, fused ring and parallel ring; R f and R g are halogen; each of the substituents in said bridged ring, fused ring or parallel ring is independently selected from Boc group, fluorinated C 1-6 alkyl, substituted or unsubstituted heterocyclyl, and alkanoyl, preferably selected from Boc group, fluoromethyl, and - COCH 3;