System for automatically manipulating flexible primary packaging in open dimensionally stable secondary packaging, together called a package, having the following system components: - flexible primary packaging with a closed and twisted upper segment in open dimensionally stable secondary packaging; - a robot module comprising a two-armed robot with a clamping gripper installed in each case at a tool centre point of the robot arm, wherein each tool centre point comprises a force-torque sensor which can provide at least measurements of the force and torque direction in degrees of freedom; - an image recording module for recording images of at least the upper segment of the primary packaging, comprising at least two stereo cameras for recording 3D images, wherein at least one of the stereo cameras is placed to the side of an air line between the package and the robot; - one or more processors for controlling the system modules, configured to carry out the following steps: - recording images by means of the image recording module; - processing images and providing a three-dimensional point cloud from the received images; - reconstructing the surface of at least the primary packaging from the three-dimensional point cloud; - calculating a highest point of the primary packaging from the surface reconstruction of the primary packaging as a gripping point for one of the clamping grippers, and - calculating a movement sequence for one of the robot arms, comprising a collision-free approach path to the calculated gripping point for the clamping gripper; - forwarding the calculated movement sequence to the robot module; - receiving the measurements from the force-torque sensors; - controlling the gripping of the primary packaging at the gripping point and the movement of the gripper, wherein the primary packaging is opened by virtue of the gripper being pulled upwards in an unscrewing manner in a movement or a rotational movement, taking into account measurements from the force-torque sensor at its tool centre point, until the stress of the primary packaging measured by the force-torque sensor reaches a predefined upper limit and/or until one of the cameras provides an image in which it can be seen that the primary packaging is sufficiently open; the system also comprising interfaces between the robot module and the processors and between the image recording module and the processors. - flexible primary packaging with a closed and twisted upper segment in open dimensionally stable secondary packaging; - a robot module comprising a two-armed robot with a clamping gripper installed in each case at a tool centre point of the robot arm, wherein each tool centre point comprises a force-torque sensor which can provide at least measurements of the force and torque direction in degrees of freedom; - an image recording module for recording images of at least the upper segment of the primary packaging, comprising at least two stereo cameras for recording 3D images, wherein at least one of the stereo cameras is placed to the side of an air line between the package and the robot; - one or more processors for controlling the system modules, configured to carry out the following steps: - recording images by means of the image recording module; - processing images and providing a three-dimensional point cloud from the received images; - reconstructing the surface of at least the primary packaging from the three-dimensional point cloud; - calculating a highest point of the primary packaging from the surface reconstruction of the primary packaging as a gripping point for one of the clamping grippers, and - calculating a movement sequence for one of the robot arms, comprising a collision-free approach path to the calculated gripping point for the clamping gripper; - forwarding the calculated movement sequence to the robot module; - receiving the measurements from the force-torque sensors; - controlling the gripping of the primary packaging at the gripping point and the movement of the gripper, wherein the primary packaging is opened by virtue of the gripper being pulled upwards in an unscrewing manner in a movement or a rotational movement, taking into account measurements from the force-torque sensor at its tool centre point, until the stress of the primary packaging measured by the force-torque sensor reaches a predefined upper limit and/or until one of the cameras provides an image in which it can be seen that the primary packaging is sufficiently open;