A process for producing a pharmaceutical composition comprising the steps: (a) forming a feed solution comprising a drug, a concentration-enhancing polymer and a solvent in which said drug and said polymer are soluble; (b) directing said feed solution to a spray-drying apparatus comprising (i) a drying chamber having a volume Vdryer and a height H, (ii) a pressure nozzle for atomizing said feed solution into droplets, (iii) a source of heated drying gas for drying said droplets, said source delivering said drying gas to said drying chamber at a flow rate of G, and (iv) gas-dispersing means for dispersing said drying gas into said drying chamber, so that its flow through the upper portion of the spray-dryer can be described as an organized plug flow away from the top of the apparatus, wherein V dryer is measured in m 3, H is at least 1 m, G is measured in m 3 /sec, and wherein the following mathematical relationship is satisfied Vdryer G ≥ 10 seconds; (c) atomizing said feed solution into droplets in said drying chamber by said pressure nozzle, said droplets having an average diameter of at least 50 μm and a D 10 of at least 10 μm; (d) contacting said droplets with said heated drying gas to form particulates of a solid amorphous dispersion of said drug and said concentration-enhancing polymer; and (e) collecting said particulates wherein said concentration-enhancing polymer is selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, carboxymethyl ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl methyl cellulose phthalate, cellulose acetate phthalate, cellulose acetate trimellitate, polyvinyl alcohols that have at least a portion of their repeat units in hydrolyzed form, polyvinyl pyrrolidone, poloxamers and blends thereof. (a) forming a feed solution comprising a drug, a concentration-enhancing polymer and a solvent in which said drug and said polymer are soluble; (b) directing said feed solution to a spray-drying apparatus comprising (i) a drying chamber having a volume Vdryer and a height H, (ii) a pressure nozzle for atomizing said feed solution into droplets, (iii) a source of heated drying gas for drying said droplets, said source delivering said drying gas to said drying chamber at a flow rate of G, and (iv) gas-dispersing means for dispersing said drying gas into said drying chamber, so that its flow through the upper portion of the spray-dryer can be described as an organized plug flow away from the top of the apparatus, wherein V dryer is measured in m 3, H is at least 1 m, G is measured in m 3 /sec, and wherein the following mathematical relationship is satisfied Vdryer G ≥ 10 seconds; (i) a drying chamber having a volume Vdryer and a height H, (ii) a pressure nozzle for atomizing said feed solution into droplets, (iii) a source of heated drying gas for drying said droplets, said source delivering said drying gas to said drying chamber at a flow rate of G, and (iv) gas-dispersing means for dispersing said drying gas into said drying chamber, so that its flow through the upper portion of the spray-dryer can be described as an organized plug flow away from the top of the apparatus, wherein V dryer is measured in m 3, H is at least 1 m, G is measured in m 3 /sec, and wherein the following mathematical relationship is satisfied Vdryer G ≥ 10 seconds; (c) atomizing said feed solution into droplets in said drying chamber by said pressure nozzle, said droplets having an average diameter of at least 50 μm and a D 10 of at least 10 μm; (d) contacting said droplets with said heated drying gas to form particulates of a solid amorphous dispersion of said drug and said concentration-enhancing polymer; and (e) collecting said particulates