A surgical system comprising: (a) an ultrasonic surgical instrument comprising: (i) an ultrasonic transducer, the transducer having a distal end and a proximal end, wherein the transducer defines a bore extending from the proximal end to the distal end, wherein the transducer is operable to convert electrical power into ultrasonic vibrations, (ii) a waveguide disposed in the bore of the transducer, wherein the waveguide has a proximal end located proximal to the proximal end of the transducer, wherein the waveguide has a distal end located distal to the distal end of the transducer, wherein the waveguide defines a lumen extending from the proximal end of the waveguide to the distal end of the waveguide, and (iii) an end effector in acoustic communication with the waveguide, wherein the waveguide is operable to transmit ultrasonic vibrations from the transducer to the end effector; (b) a horn coaxially disposed about the waveguide, wherein the horn is distal to the transducer, wherein the horn is configured to be brought in contact with the waveguide; (c) a compression nut coaxially disposed about the waveguide, wherein the compression nut is proximal to the transducer, wherein the compression nut is operable to urge the transducer toward the horn and thereby urge the horn into engagement with the waveguide so that the horn transmits ultrasonic vibrations generated by the transducer to the waveguide; and (d) a conduit coupled with the lumen of the waveguide, wherein the conduit is operable to communicate with one or both of a vacuum source or a fluid source to transmit one or both of suction or fluid through the lumen. (a) an ultrasonic surgical instrument comprising: (i) an ultrasonic transducer, the transducer having a distal end and a proximal end, wherein the transducer defines a bore extending from the proximal end to the distal end, wherein the transducer is operable to convert electrical power into ultrasonic vibrations, (ii) a waveguide disposed in the bore of the transducer, wherein the waveguide has a proximal end located proximal to the proximal end of the transducer, wherein the waveguide has a distal end located distal to the distal end of the transducer, wherein the waveguide defines a lumen extending from the proximal end of the waveguide to the distal end of the waveguide, and (iii) an end effector in acoustic communication with the waveguide, wherein the waveguide is operable to transmit ultrasonic vibrations from the transducer to the end effector; (i) an ultrasonic transducer, the transducer having a distal end and a proximal end, wherein the transducer defines a bore extending from the proximal end to the distal end, wherein the transducer is operable to convert electrical power into ultrasonic vibrations, (ii) a waveguide disposed in the bore of the transducer, wherein the waveguide has a proximal end located proximal to the proximal end of the transducer, wherein the waveguide has a distal end located distal to the distal end of the transducer, wherein the waveguide defines a lumen extending from the proximal end of the waveguide to the distal end of the waveguide, and (iii) an end effector in acoustic communication with the waveguide, wherein the waveguide is operable to transmit ultrasonic vibrations from the transducer to the end effector; (b) a horn coaxially disposed about the waveguide, wherein the horn is distal to the transducer, wherein the horn is configured to be brought in contact with the waveguide; (c) a compression nut coaxially disposed about the waveguide, wherein the compression nut is proximal to the transducer, wherein the compression nut is operable to urge the transducer toward the horn and thereby urge the horn into engagement with the waveguide so that the horn transmits ultrasonic vibrations generated by the transducer to the waveguide; and (d) a conduit coupled with the lumen of the waveguide, wherein the conduit is operable to communicate with one or both of a vacuum source or a fluid source to transmit one or both of suction or fluid through the lumen.