Compounds of the formula: with NR 1 R 2 is Z is R representing cyanoalkyl; monohalogenocyanoalkyl; polyhalogenocyanoalkyl; hydroxyalkyl; monohalogenoalkyl (with halogen being Cl, Br or I); polyhalogenoalkyl; alkoxyalkyl; monohalogeno-alkoxyalkyl; polyhalogenoalkoxyalkyl; alkoxyalkoxyalkyl; monohalogeno-alkoxyalkoxyalkyl; polyhalogenoalkoxyalkoxyalkyl; aryloxyalkyl; mono- or polyhalogenoaryloxyalkyl; cycloalkenylalkyl; dialkylaminoalkyl; halodialkylaminoalkyl; polyhalogenodialkylaminoalkyl; where is a non aromatic heterocycle optionally fused with aryl or optionally substituted with one or more acyl, alkyl or halogen; arylaminoalkyl; alkylcarbonylalkyl; acylaminoalkyl; aminocarbonylalkyl; alkylsulfanylalkyl; alkylsulfinylalkyl; alkylsulfonylalkyl; m being 2 or 4; Ar representing an aryl; an heteroaryl or an aryl fused with a cycloalkyl or an heterocycle; Ar being optionally substituted with one or more alkyl; alkenyl; alkynyl; cyano; halogeno; alkoxy; monohalogenoalkoxy; polyhalogenoalkoxy; alkoxyalkyl; dialkylamino; non aromatic heterocyclyl attached by a nitrogen; alkylsulfanyl; alkylsulfinyl; alkylsulfonyl; monohalogenoalkylsulfanyl; monohalogenoalkylsulfinyl; monohalogenoalkylsulfonyl; polyhalogenoalkylsulfanyl; polyhalogenoalkylsulfinyl; polyhalogenoalkylsulfonyl; heteroaryl; aryl; aralkyl; aryloxy; alkoxy-carbonylamino; acyl; acylamino; aminocarbonyl; monoalkylaminocarbonyl; dialkylaminocarbonyl; alkylsulfonylamino; monohalogenoalkyl; polyhalogenoalkyl; hydroxyl; hydroxyalkyl; oxoalkyl; or their pharmaceutically acceptable salts, hydrates, or hydrated salts, or the polymorphic, cristalline structures of these compounds or their optical isomers, racemates, diastereomers or enantiomers; wherein: "Alkyl" means an aliphatic hydrocarbon group which may be straight or branched having 1 to 12 carbon atoms in the chain; "Alkenyl" means an aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be straight or branched having 2 to 4 carbon atoms in the chain; "Alkynyl" means an aliphatic hydrocarbon group containing a carbon-carbon triple bond and which may be straight or branched having 2 to 4 carbon atoms in the chain; "Aryl" means an aromatic monocyclic or multicyclic hydrocarbon ring system of 6 to 10 carbon atoms; "Cycloalkyl" means a non-aromatic mono- or multicyclic hydrocarbon ring system of 5 to 6 carbon atoms; "Cycloalkenyl" means a non-aromatic mono- or multicyclic ring system of about 5 to about 10 carbon atoms, and which contains at least one carbon-carbon double bond; "Heteroaryl" or aromatic heterocycles refers to a 5 to 10 membered aromatic hetero, mono-, bi- or multicyclic ring; "Heterocycle" or "Heterocyclic" refer to a saturated, partially unsaturated or unsaturated, non aromatic stable 5 to 10 membered mono, bi or multicyclic rings wherein at least one member of the ring is a hetero atom. "Alkyl" means an aliphatic hydrocarbon group which may be straight or branched having 1 to 12 carbon atoms in the chain; "Alkenyl" means an aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be straight or branched having 2 to 4 carbon atoms in the chain; "Alkynyl" means an aliphatic hydrocarbon group containing a carbon-carbon triple bond and which may be straight or branched having 2 to 4 carbon atoms in the chain; "Aryl" means an aromatic monocyclic or multicyclic hydrocarbon ring system of 6 to 10 carbon atoms; "Cycloalkyl" means a non-aromatic mono- or multicyclic hydrocarbon ring system of 5 to 6 carbon atoms; "Cycloalkenyl" means a non-aromatic mono- or multicyclic ring system of about 5 to about 10 carbon atoms, and which contains at least one carbon-carbon double bond; "Heteroaryl" or aromatic heterocycles refers to a 5 to 10 membered aromatic hetero, mono-, bi- or multicyclic ring; "Heterocycle" or "Heterocyclic" refer to a saturated, partially unsaturated or unsaturated, non aromatic stable 5 to 10 membered mono, bi or multicyclic rings wherein at least one member of the ring is a hetero atom.