A method of making a compound of Formula (I-F), or a salt thereof, comprising the steps of: (a) decomplexing and protecting of a compound of Formula: to form a compound of Formula (I-B): (b) protecting a compound of Formula (I-B) to form a compound of Formula (I-C): (c) halomethylating a compound of Formula (I-C) to form a compound of Formula (I-D): (d) aminating a compound of Formula (I-D) and reacting with a compound of formula: to form a compound of Formula (I-E): (e) deprotecting a compound of Formula (I-E) to form a compound of Formula (I-F): wherein the deprotection comprises de-esterification and de-complexation; wherein: PG is a hydroxyl protecting group; n is 0 or 1; Y 1 is O or N + R 5 R 6; Y 2 is O or NR 10; R 1 and R 2 are independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 2, together with the atoms to which they are attached, form =O; R 3 is selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 3, together with the atoms to which they are attached, form a carbocyclic ring; or R 3 and R 5, together with the atoms to which they are attached, form a heteroaryl ring; or R 3 and R 4, together with the atoms to which they are attached, form =O; R 4, R 5, R 6, and R 10 are each independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; R 9 is selected from the group consisting of optionally substituted C 1 -C 12 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted aryl, and optionally substituted heteroaryl; R 13 is selected from the group consisting of C 1-9 alkyl and C 1-9 alkyl-R 14; and R 14 is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl. (a) decomplexing and protecting of a compound of Formula: to form a compound of Formula (I-B): (b) protecting a compound of Formula (I-B) to form a compound of Formula (I-C): (c) halomethylating a compound of Formula (I-C) to form a compound of Formula (I-D): (d) aminating a compound of Formula (I-D) and reacting with a compound of formula: to form a compound of Formula (I-E): (e) deprotecting a compound of Formula (I-E) to form a compound of Formula (I-F): wherein the deprotection comprises de-esterification and de-complexation; wherein: PG is a hydroxyl protecting group; n is 0 or 1; Y 1 is O or N + R 5 R 6; Y 2 is O or NR 10; R 1 and R 2 are independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 2, together with the atoms to which they are attached, form =O; R 3 is selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 3, together with the atoms to which they are attached, form a carbocyclic ring; or R 3 and R 5, together with the atoms to which they are attached, form a heteroaryl ring; or R 3 and R 4, together with the atoms to which they are attached, form =O; R 4, R 5, R 6, and R 10 are each independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; R 9 is selected from the group consisting of optionally substituted C 1 -C 12 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted aryl, and optionally substituted heteroaryl; R 13 is selected from the group consisting of C 1-9 alkyl and C 1-9 alkyl-R 14; and R 14 is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl. PG is a hydroxyl protecting group; n is 0 or 1; Y 1 is O or N + R 5 R 6; Y 2 is O or NR 10; R 1 and R 2 are independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 2, together with the atoms to which they are attached, form =O; R 3 is selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; or R 1 and R 3, together with the atoms to which they are attached, form a carbocyclic ring; or R 3 and R 5, together with the atoms to which they are attached, form a heteroaryl ring; or R 3 and R 4, together with the atoms to which they are attached, form =O; R 4, R 5, R 6, and R 10 are each independently selected from the group consisting of H, optionally substituted phenyl, and optionally substituted C 1-4 alkyl; R 9 is selected from the group consisting of optionally substituted C 1 -C 12 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted aryl, and optionally substituted heteroaryl; R 13 is selected from the group consisting of C 1-9 alkyl and C 1-9 alkyl-R 14; and R 14 is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl.