A compound of formula or a pharmaceutically acceptable salt or solvate thereof, wherein Ar is selected from the group consisting of phenyl and heteroaryl, each of which is optionally substituted by one or more independently selected substituents R Ar; R Ar is selected from the group consisting of halogen, -OH, -CN, alkoxy, haloalkoxy, alkyl, haloalkyl, mono- or dialkylamino-alkyl, mono- or di-alkylamino-alkoxy, -COOR', -CONHR', -CO-R', -SO 2 NHR', -NH-CO-R', -NO 2, -NH-SO 2 -R', -SO 2 -R', benzyloxy, -CO-heterocyclyl, -CO-cycloalkyl, -CONH-cycloalkyl, -CONH-heterocyclyl, -O-alkyl-heterocyclyl, -O-alkyl-cycloalkyl, (2-oxa-6-azaspiro[3.3]hept-6-yl)-C 1-4 -alkoxy, amino, aralkyl, cycloalkyl, heterocyclyl, phenyl and heteroaryl, wherein each of said alkoxy, aralkyl, alkyl, cycloalkyl, heterocyclyl, phenyl and heteroaryl groups is optionally substituted be one or more substituents independently selected from alkyl, haloalkyl, halogen and OH, and wherein R' is independently selected from the group consisting of independently represents H, OH, alkyl and haloalkyl; Z is selected from the group consisting of H, halogen, -CO-R Z, -CH 2 -O-R Z, -CO-CH 2 -R Z, -CO-CH 2 -O-R Z, -COOR Z, -NHCO-R Z, -CO-NHR Z, -N(R Z) 2, -CN,-NHCOOR Z, -SO 2 -R Z, -SO 2 NHR Z, -alkyl-O-R Z, -alkyl-O-alkyl-O-R Z, amino, alkyl, phenyl, heteroaryl, heterocyclyl and cycloalkyl, wherein each of said alkyl, phenyl, heteroaryl, heterocyclyl and cycloalkyl groups is optionally substituted be one or more substituents independently selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, -COO-alkyl, OH and cycloalkyl; R Z is selected from the group consisting of H, halogen, -OH, alkyl, haloalkyl, cycloalkyl, heterocyclyl, heterocyclyl, phenyl and heteroaryl, Y is H, halogen, haloalkyl, alkyl or an alkylester; R1 is a group of the structure wherein n is 0 or 1; and R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked ∗. Ar is selected from the group consisting of phenyl and heteroaryl, each of which is optionally substituted by one or more independently selected substituents R Ar; R Ar is selected from the group consisting of halogen, -OH, -CN, alkoxy, haloalkoxy, alkyl, haloalkyl, mono- or dialkylamino-alkyl, mono- or di-alkylamino-alkoxy, -COOR', -CONHR', -CO-R', -SO 2 NHR', -NH-CO-R', -NO 2, -NH-SO 2 -R', -SO 2 -R', benzyloxy, -CO-heterocyclyl, -CO-cycloalkyl, -CONH-cycloalkyl, -CONH-heterocyclyl, -O-alkyl-heterocyclyl, -O-alkyl-cycloalkyl, (2-oxa-6-azaspiro[3.3]hept-6-yl)-C 1-4 -alkoxy, amino, aralkyl, cycloalkyl, heterocyclyl, phenyl and heteroaryl, wherein each of said alkoxy, aralkyl, alkyl, cycloalkyl, heterocyclyl, phenyl and heteroaryl groups is optionally substituted be one or more substituents independently selected from alkyl, haloalkyl, halogen and OH, and wherein R' is independently selected from the group consisting of independently represents H, OH, alkyl and haloalkyl; Z is selected from the group consisting of H, halogen, -CO-R Z, -CH 2 -O-R Z, -CO-CH 2 -R Z, -CO-CH 2 -O-R Z, -COOR Z, -NHCO-R Z, -CO-NHR Z, -N(R Z) 2, -CN,-NHCOOR Z, -SO 2 -R Z, -SO 2 NHR Z, -alkyl-O-R Z, -alkyl-O-alkyl-O-R Z, amino, alkyl, phenyl, heteroaryl, heterocyclyl and cycloalkyl, wherein each of said alkyl, phenyl, heteroaryl, heterocyclyl and cycloalkyl groups is optionally substituted be one or more substituents independently selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, -COO-alkyl, OH and cycloalkyl; R Z is selected from the group consisting of H, halogen, -OH, alkyl, haloalkyl, cycloalkyl, heterocyclyl, heterocyclyl, phenyl and heteroaryl, Y is H, halogen, haloalkyl, alkyl or an alkylester; R1 is a group of the structure n is 0 or 1; and R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked ∗.