A shoe sole comprising an outsole having a tread surface to be in contact with a road surface, and a midsole arranged on the outsole, wherein: the midsole includes a lower midsole of a lower layer formed by a foamed body of a resin, and an upper midsole of an upper layer formed by a foamed body of a resin and arranged on the lower midsole; the upper midsole of the upper layer includes: a lateral portion that covers a lower surface of a metatarsal bone of a fifth toe from a head to a bottom thereof; and a medial portion that covers a lower surface of a metatarsal bone of a first toe from a head to a bottom thereof and a lower surface of a proximal phalanx (B3 1); a lateral roll-up portion for supporting a lateral side of a foot from a side of the foot and a base portion, which has a large thickness, of the lateral roll-up portion of the lower midsole are formed integrally with the lower midsole; a hardness of a lateral portion of the lower midsole including the lateral roll-up portion and the base portion that has a large thickness is a first hardness; a hardness of a medial portion of the lower midsole is a second hardness lower than the first hardness; a hardness of the lateral portion of the upper midsole is a third hardness lower than the first hardness; the lateral portion of the upper midsole is hollowed out and narrowed in the area of the head of the metatarsal bone of the fifth toe; in the area of the head of the metatarsal bone of the fifth toe, an outer edge line of the lateral portion of the upper midsole is curved so as to protrude toward the medial side, and the lateral portion of the upper midsole does not cover at least one portion of an MP joint (MP 5) of the fifth toe; in the area of the head of the metatarsal bone of the fifth toe, an outer edge line of the lateral portion of the lower midsole is curved so as to protrude toward the lateral side, and the lateral portion of the lower midsole covers at least one portion of the MP joint (MP 5) of the fifth toe; and a part or a whole of the high-hardness lateral roll-up portion is protruding in an upward direction in the narrowed area of the upper midsole past the upper midsole on a lateral side of the upper midsole so that the lateral side of the foot is supported by the lateral roll-up portion from the side of the foot without being supported by the upper midsole from the side of the foot. the midsole includes a lower midsole of a lower layer formed by a foamed body of a resin, and an upper midsole of an upper layer formed by a foamed body of a resin and arranged on the lower midsole; the upper midsole of the upper layer includes: a lateral portion that covers a lower surface of a metatarsal bone of a fifth toe from a head to a bottom thereof; and a medial portion that covers a lower surface of a metatarsal bone of a first toe from a head to a bottom thereof and a lower surface of a proximal phalanx (B3 1); a lateral roll-up portion for supporting a lateral side of a foot from a side of the foot and a base portion, which has a large thickness, of the lateral roll-up portion of the lower midsole are formed integrally with the lower midsole; a hardness of a lateral portion of the lower midsole including the lateral roll-up portion and the base portion that has a large thickness is a first hardness; a hardness of a medial portion of the lower midsole is a second hardness lower than the first hardness; a hardness of the lateral portion of the upper midsole is a third hardness lower than the first hardness; the lateral portion of the upper midsole is hollowed out and narrowed in the area of the head of the metatarsal bone of the fifth toe; in the area of the head of the metatarsal bone of the fifth toe, an outer edge line of the lateral portion of the upper midsole is curved so as to protrude toward the medial side, and the lateral portion of the upper midsole does not cover at least one portion of an MP joint (MP 5) of the fifth toe; in the area of the head of the metatarsal bone of the fifth toe, an outer edge line of the lateral portion of the lower midsole is curved so as to protrude toward the lateral side, and the lateral portion of the lower midsole covers at least one portion of the MP joint (MP 5) of the fifth toe; and a part or a whole of the high-hardness lateral roll-up portion is protruding in an upward direction in the narrowed area of the upper midsole past the upper midsole on a lateral side of the upper midsole so that the lateral side of the foot is supported by the lateral roll-up portion from the side of the foot without being supported by the upper midsole from the side of the foot.