A dispensing system for use in cryogenic skin treatment, said system comprising: • a container having an internal volume of 10-200 ml, said container comprising a liquid phase in direct contact and in equilibrium with a gas phase at a pressure of 2.5-8 bar, said liquid phase comprising at least 50 wt.% liquefied dimethyl ether; • an actuatable valve attached to the container, said valve comprising ∘ a mixing chamber having an operational internal volume of 10-600 μl and comprising an inlet and an outlet, wherein the inlet comprises a Venturi tube having an entry cone for receiving gas phase from the container, an exit cone and a constricted section that connects the entry cone with the exit cone, said constricted section or said exit cone comprising a liquid inlet for receiving liquid phase from the container, the liquid inlet having a cross-sectional opening area of 8x10 -3 to 100x10 -3 mm 2 and the constricted section having a cross-sectional opening area that is at least 150% larger than the cross-sectional area of the liquid inlet ∘ a nozzle connected to the outlet of the mixing chamber, said nozzle comprising an orifice with a cross-sectional opening area in the range of 8x10 -3 to 100x10 -3 mm 2; • a spacer attached to the container or to the valve, said spacer being adapted for defining a predetermined distance between the orifice of the nozzle and a skin surface to be treated; the distal end of the spacer being provided with a spray opening, the distance between said spray opening and the orifice of the nozzle being in the range of 2 to 25 mm; wherein the dispensing system is arranged to be used in a top-down position with the distal end of the spacer being in placed in direct contact with skin around a skin surface to be treated and the nozzle being located below the container; and wherein, upon actuation of the valve during such top-down use: • the gas phase enters the mixing chamber through the Venturi tube thereby creating a Venturi effect that (i) draws the liquid phase into the Venturi tube via the liquid inlet and (ii) causes dispersal of the liquid phase into the gas phase; and • the resulting cryogenic liquid-in-gas dispersion is expelled through the orifice of the nozzle and through the spray opening of the spacer to deliver the cryogenic dispersion to the skin surface to be treated at a rate of 30-200 mg/s. • a container having an internal volume of 10-200 ml, said container comprising a liquid phase in direct contact and in equilibrium with a gas phase at a pressure of 2.5-8 bar, said liquid phase comprising at least 50 wt.% liquefied dimethyl ether; • an actuatable valve attached to the container, said valve comprising ∘ a mixing chamber having an operational internal volume of 10-600 μl and comprising an inlet and an outlet, wherein the inlet comprises a Venturi tube having an entry cone for receiving gas phase from the container, an exit cone and a constricted section that connects the entry cone with the exit cone, said constricted section or said exit cone comprising a liquid inlet for receiving liquid phase from the container, the liquid inlet having a cross-sectional opening area of 8x10 -3 to 100x10 -3 mm 2 and the constricted section having a cross-sectional opening area that is at least 150% larger than the cross-sectional area of the liquid inlet ∘ a nozzle connected to the outlet of the mixing chamber, said nozzle comprising an orifice with a cross-sectional opening area in the range of 8x10 -3 to 100x10 -3 mm 2; ∘ a mixing chamber having an operational internal volume of 10-600 μl and comprising an inlet and an outlet, wherein the inlet comprises a Venturi tube having an entry cone for receiving gas phase from the container, an exit cone and a constricted section that connects the entry cone with the exit cone, said constricted section or said exit cone comprising a liquid inlet for receiving liquid phase from the container, the liquid inlet having a cross-sectional opening area of 8x10 -3 to 100x10 -3 mm 2 and the constricted section having a cross-sectional opening area that is at least 150% larger than the cross-sectional area of the liquid inlet ∘ a nozzle connected to the outlet of the mixing chamber, said nozzle comprising an orifice with a cross-sectional opening area in the range of 8x10 -3 to 100x10 -3 mm 2; • a spacer attached to the container or to the valve, said spacer being adapted for defining a predetermined distance between the orifice of the nozzle and a skin surface to be treated; the distal end of the spacer being provided with a spray opening, the distance between said spray opening and the orifice of the nozzle being in the range of 2 to 25 mm; • the gas phase enters the mixing chamber through the Venturi tube thereby creating a Venturi effect that (i) draws the liquid phase into the Venturi tube via the liquid inlet and (ii) causes dispersal of the liquid phase into the gas phase; and • the resulting cryogenic liquid-in-gas dispersion is expelled through the orifice of the nozzle and through the spray opening of the spacer to deliver the cryogenic dispersion to the skin surface to be treated at a rate of 30-200 mg/s.