A selection method for separating target cells from non-target cells in a sample comprising target cells, secondary targets and non-target cells, the method comprising: a) contacting the sample with a first antibody composition comprising (a) at least one antibody that binds to the target cells wherein the at least one antibody is linked, either directly or indirectly, to (b) at least one antibody that binds to the secondary targets, under conditions to allow immunorosettes of the target cells and the secondary targets to form; b) contacting the sample with a second antibody composition comprising: (i) (a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody that binds to the secondary targets linked, either directly or indirectly, to (b) at least one antibody that binds to a particle, or (ii)(a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody directly bound to a particle using conventional techniques, under conditions to allow binding of the particle to the immunorosettes and/or the secondary targets; and c) separating the immunorosette-particle complexes and/or the secondary target-particle complexes from the sample to separate the target cells from the non-target cells wherein (i) the particle is a magnetic particle, and the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes are separated from the sample in step c) by density separation, by sedimentation, or by placing the sample in a magnetic field gradient of sufficient strength to separate the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes from the sample, or (ii) the particle is a non-magnetic particle optionally non-magnetic buoyant particles, and the immunorosette-particle complexes and/or the secondary target-particle complexes are separated from the sample in step c) by density separation or by sedimentation. a) contacting the sample with a first antibody composition comprising (a) at least one antibody that binds to the target cells wherein the at least one antibody is linked, either directly or indirectly, to (b) at least one antibody that binds to the secondary targets, under conditions to allow immunorosettes of the target cells and the secondary targets to form; b) contacting the sample with a second antibody composition comprising: (i) (a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody that binds to the secondary targets linked, either directly or indirectly, to (b) at least one antibody that binds to a particle, or (ii)(a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody directly bound to a particle using conventional techniques, under conditions to allow binding of the particle to the immunorosettes and/or the secondary targets; and (i) (a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody that binds to the secondary targets linked, either directly or indirectly, to (b) at least one antibody that binds to a particle, or (ii)(a) at least one antibody that binds to the secondary targets either singly or within the immunorosettes, the at least one antibody directly bound to a particle using conventional techniques, c) separating the immunorosette-particle complexes and/or the secondary target-particle complexes from the sample to separate the target cells from the non-target cells wherein (i) the particle is a magnetic particle, and the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes are separated from the sample in step c) by density separation, by sedimentation, or by placing the sample in a magnetic field gradient of sufficient strength to separate the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes from the sample, or (ii) the particle is a non-magnetic particle optionally non-magnetic buoyant particles, and the immunorosette-particle complexes and/or the secondary target-particle complexes are separated from the sample in step c) by density separation or by sedimentation. (i) the particle is a magnetic particle, and the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes are separated from the sample in step c) by density separation, by sedimentation, or by placing the sample in a magnetic field gradient of sufficient strength to separate the immunorosette-magnetic particle complexes and/or the secondary target-magnetic particle complexes from the sample, or (ii) the particle is a non-magnetic particle optionally non-magnetic buoyant particles, and the immunorosette-particle complexes and/or the secondary target-particle complexes are separated from the sample in step c) by density separation or by sedimentation.