A compound for use in the treatment of ocular inflammatory disorders or skin inflammatory diseases having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, wherein: R 1 is H or substituted or unsubstituted C 1-6 alkyl; R 2 is H or substituted or unsubstituted C 1-6 alkyl; R 3 is N or C-R 7; R 4 is N or C-R 8; R 5 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or is substituted or unsubstituted C 6-10 aryl; R 6 is 2-benzofuran, 2 -thienyl, 5-chloro-2-thienyl, 4,5-dichloro-2-thienyl, 4-chloro-3-methylphenyl, or 4-chloro-3-trifluoromethylphenyl; R 15 is N or C-R 16; R 17 is N or C-R 18; R 7 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 9, NR 10 R 11 or hydroxyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; R 16 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 19, NR 20 R 21 or hydroxyl; R 18 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 22, NR 23 R 24 or hydroxyl; R 9 is H or substituted or unsubstituted C 1-6 alkyl; R 10 is H or substituted or unsubstituted C 1-6 alkyl; R 11 is H or substituted or unsubstituted C 1-6 alkyl; R 12 is H or substituted or unsubstituted C 1-6 alkyl; R 13 is H or substituted or unsubstituted C 1-6 alkyl; R 14 is H or substituted or unsubstituted C 1-6 alkyl; R 19 is H or substituted or unsubstituted C 1-6 alkyl; R 20 is H or substituted or unsubstituted C 1-6 alkyl; R 21 is H or substituted or unsubstituted C 1-6 alkyl; R 22 is H or substituted or unsubstituted C 1-6 alkyl; R 23 is H or substituted or unsubstituted C 1-6 alkyl; R 24 is H or substituted or unsubstituted C 1-6 alkyl; wherein alkyl, heterocycle and aryl may be substituted with halogens, -OH, C 3-8 cycloalkyl, non-aromatic heterocycles, aromatic heterocycles, -OC 1-6 alkyl, -NH 2, -NO 2, amides, ethers, esters, aldehydes, ketones, sulfonamides groups, aryl, carboxylic acid, phosphonic acid groups, sulphonic acid groups, and phosphoric acid; and cycloalkyl, cycloalkenyl, and alkenyl may be substituted with halogens, -OH, C 3-8 cycloalkyl, non-aromatic heterocycles, aromatic heterocycles, -OC 1-6 alkyl, -NH 2, - NO 2, amides, ethers, esters, aldehydes, sulfonamides groups, aryl, carboxylic acid, phosphonic acid groups, sulphonic acid groups, and phosphoric acid; and with the provisos: a). R 6 is not the same as R 5; b). when R 5 is a substituted heterocycle then it is not c). when R 6 is 2-thienyl then R 7, R 8, R 16 and R 18 are not all hydrogen in same time; d). the compound is not of the following structures: R 1 is H or substituted or unsubstituted C 1-6 alkyl; R 2 is H or substituted or unsubstituted C 1-6 alkyl; R 3 is N or C-R 7; R 4 is N or C-R 8; R 5 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or is substituted or unsubstituted C 6-10 aryl; R 6 is 2-benzofuran, 2 -thienyl, 5-chloro-2-thienyl, 4,5-dichloro-2-thienyl, 4-chloro-3-methylphenyl, or 4-chloro-3-trifluoromethylphenyl; R 15 is N or C-R 16; R 17 is N or C-R 18; R 7 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 9, NR 10 R 11 or hydroxyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; R 16 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 19, NR 20 R 21 or hydroxyl; R 18 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-3 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 22, NR 23 R 24 or hydroxyl; R 9 is H or substituted or unsubstituted C 1-6 alkyl; R 10 is H or substituted or unsubstituted C 1-6 alkyl; R 11 is H or substituted or unsubstituted C 1-6 alkyl; R 12 is H or substituted or unsubstituted C 1-6 alkyl; R 13 is H or substituted or unsubstituted C 1-6 alkyl; R 14 is H or substituted or unsubstituted C 1-6 alkyl; R 19 is H or substituted or unsubstituted C 1-6 alkyl; R 20 is H or substituted or unsubstituted C 1-6 alkyl; R 21 is H or substituted or unsubstituted C 1-6 alkyl; R 22 is H or substituted or unsubstituted C 1-6 alkyl; R 23 is H or substituted or unsubstituted C 1-6 alkyl; R 24 is H or substituted or unsubstituted C 1-6 alkyl; a). R 6 is not the same as R 5; b). when R 5 is a substituted heterocycle then it is not c). when R 6 is 2-thienyl then R 7, R 8, R 16 and R 18 are not all hydrogen in same time; d). the compound is not of the following structures: