A compound of formula I, or a pharmaceutically acceptable salt, a solvate thereof, or a mixture thereof, wherein the compound of formula I is formed by linking the following fragment A and fragment B, wherein, R 1, R 2 and R 3 are each independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, and substituted heterocyclyl; or R 2, R 3 and attached N together form 3-7 membered saturated or unsaturated heterocycle containing 1-3 N, 0-2 O and/or 0-2 S atoms, wherein the "heterocycle" is unsubstituted, monosubstituted or polysubstituted by the following group(s): H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, alkanoyl, and substituted alkanoyl; R 4a and R 4b are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, and substituted alkyl; or R 4a, R 4b and attached C together form 3-7 membered saturated or unsaturated heterocycle containing 1-3 N, 0-2 O and/or 0-2 S atoms, wherein the "heterocycle" is unsubstituted, monosubstituted or polysubstituted by the following group(s): hydrogen, hydroxy, alkyl, and substituted alkyl; X 1 is O, S or NR 5, R 5 is selected from the group consisting of hydrogen, alkyl, cyano, hydroxy, and alkoxy; X 2 is O or NH; R 6a, R 6b, R 6c, R 6d, R 6e, R 6f, R 7a, R 7b, R 8a, R 8b, R 9a, R 9b, R 10a, and R 10b are each independently selected from the group consisting of absent, hydrogen, and hydroxy; " - - - "represents a single bond; each * independently represents a racemic, S or R configuration; which is a 5.beta-compound. wherein the compound of formula I is formed by linking the following fragment A and fragment B, wherein, R 1, R 2 and R 3 are each independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, and substituted heterocyclyl; or R 2, R 3 and attached N together form 3-7 membered saturated or unsaturated heterocycle containing 1-3 N, 0-2 O and/or 0-2 S atoms, wherein the "heterocycle" is unsubstituted, monosubstituted or polysubstituted by the following group(s): H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, alkanoyl, and substituted alkanoyl; R 4a and R 4b are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, and substituted alkyl; or R 4a, R 4b and attached C together form 3-7 membered saturated or unsaturated heterocycle containing 1-3 N, 0-2 O and/or 0-2 S atoms, wherein the "heterocycle" is unsubstituted, monosubstituted or polysubstituted by the following group(s): hydrogen, hydroxy, alkyl, and substituted alkyl; X 1 is O, S or NR 5, R 5 is selected from the group consisting of hydrogen, alkyl, cyano, hydroxy, and alkoxy; X 2 is O or NH; R 6a, R 6b, R 6c, R 6d, R 6e, R 6f, R 7a, R 7b, R 8a, R 8b, R 9a, R 9b, R 10a, and R 10b are each independently selected from the group consisting of absent, hydrogen, and hydroxy; " - - - "represents a single bond; each * independently represents a racemic, S or R configuration; which is a 5.beta-compound.