A compound of Formula: wherein: R 1 and R 2 are each independently -(C 1 -C 6)alkyl-NR 21 R 22; R 6, R 7, and R 8 are each independently H, or -(C 1 -C 6)alkyl; R 9 is H, -(C 1 -C 6)alkyl, -(C 1 -C 6)haloalkyl, or -(C 3 -C 6)cycloalkyl; R 10 is H, or -(C 1 -C 6)alkyl; R 11 and R 12 are each independently H, -NH 2, -(C 1 -C 6)alkyl, -(C 1 -C 6)alkyl-OR 23, -(C 1 -C 6)alkyl-SR 23, -(C 1 -C 6)alkyl-C OR 23, -(C 1 -C 6)alkyl-NR 21 R 22, -(C 1 -C 6)alkyl-CN, -(C 1 -C 6)alkyl-C NR 25 R 26, -(C 1 -C 6)alkyl-S -(C 1 -C 6)alkyl, -(C 1 -C 6)alkyl-N CH=NH, -(C 1 -C 6)alkyl-N C NH 2, -(C 1 -C 6)alkyl-heterocycloalkyl, -(C 1 -C 6)alkyl-N heterocycloalkyl, or -(C 1 -C 6)alkyl-heteroaryl; or R 11 and R 18 are combined to form a heterocycloalkyl ring, and R 12 is H; R 15, R 16, R 17, and R 18 are each independently H, -(C 1 -C 6)alkyl, -(C 3 -C 6)cycloalkyl, -(C 1 -C 6)alkyl-OR 23, -(C 1 -C 6)alkyl-C OR 23, or -(C 1 -C 6)alkyl-NR 21 R 22; A is -CN, -CH 2 CN, -CH=CHCN, -CH 2 N C CH 2 CN, - CH 2 N C N R 24, -C N R 34, -C N C(R 23) 2 C OR 29, -C N C(R 23) 2 C NR 32 R 33, -C N C(R 23) 2 C=NR 30, -C N SO 3 H, -C N SO 2 CH=CH 2, -C N N(R 24)C CH=CH 2, -C N N(R 24)C CH 2 Cl, X is aryl or heteroaryl; Y is a bond, -(C 1 -C 6)alkyl-, -O-(C 1 -C 6)alkyl-, aryl, or heteroaryl; Z is halogen, -(C 1 -C 12)alkyl, -(C 3 -C 7)cycloalkyl, aryl, or heteroaryl; or, wherein X-Y-Z is each R 21 and R 22 is independently H, -(C 1 -C 6)alkyl, -(C 1 -C 6)heteroalkyl, -(C 1 -C 6)alkyl-CO 2 H, -C (C 1 -C 6)alkyl, -C N(R 31) 2, -SO 2 N(R 31) 2; or R 21 and R 22 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 31 is independently H or -(C 1 -C 6)alkyl; or two R 31 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 23 is independently H or -(C 1 -C 6)alkyl; each R 24 is independently H or -(C 1 -C 6)alkyl; each R 25 and R 26 is independently H or -(C 1 -C 6)alkyl; or R 25 and R 26 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 27 is independently halogen, -(C 1 -C 6)alkyl, or -(C 1 -C 6)heteroalkyl; each R 28 is independently halogen, -(C 1 -C 6)alkyl, or -(C 1 -C 6)heteroalkyl; R 29 is -CH 2 C NH 2 or aryl; R 30 is R 32 is H or -(C 1 -C 6)alkyl; R 33 is -CH 2 CN, -OC (C 1 -C 6)alkyl, or -SO 2 NH 2; R 34 is -OH, -NH 2, -CN, -CH 2 CH 2 CN, -O(C 1 -C 6)alkyl, -C (C 1 -C 6)alkyl, - SO 2 NH 2, p is 0, 1, or 2; and q is 0, 1, or 2; or a pharmaceutically acceptable salt or solvate thereof. R 1 and R 2 are each independently -(C 1 -C 6)alkyl-NR 21 R 22; R 6, R 7, and R 8 are each independently H, or -(C 1 -C 6)alkyl; R 9 is H, -(C 1 -C 6)alkyl, -(C 1 -C 6)haloalkyl, or -(C 3 -C 6)cycloalkyl; R 10 is H, or -(C 1 -C 6)alkyl; R 11 and R 12 are each independently H, -NH 2, -(C 1 -C 6)alkyl, -(C 1 -C 6)alkyl-OR 23, -(C 1 -C 6)alkyl-SR 23, -(C 1 -C 6)alkyl-C OR 23, -(C 1 -C 6)alkyl-NR 21 R 22, -(C 1 -C 6)alkyl-CN, -(C 1 -C 6)alkyl-C NR 25 R 26, -(C 1 -C 6)alkyl-S -(C 1 -C 6)alkyl, -(C 1 -C 6)alkyl-N CH=NH, -(C 1 -C 6)alkyl-N C NH 2, -(C 1 -C 6)alkyl-heterocycloalkyl, -(C 1 -C 6)alkyl-N heterocycloalkyl, or -(C 1 -C 6)alkyl-heteroaryl; or R 11 and R 18 are combined to form a heterocycloalkyl ring, and R 12 is H; R 15, R 16, R 17, and R 18 are each independently H, -(C 1 -C 6)alkyl, -(C 3 -C 6)cycloalkyl, -(C 1 -C 6)alkyl-OR 23, -(C 1 -C 6)alkyl-C OR 23, or -(C 1 -C 6)alkyl-NR 21 R 22; A is -CN, -CH 2 CN, -CH=CHCN, -CH 2 N C CH 2 CN, - CH 2 N C N R 24, -C N R 34, -C N C(R 23) 2 C OR 29, -C N C(R 23) 2 C NR 32 R 33, -C N C(R 23) 2 C=NR 30, -C N SO 3 H, -C N SO 2 CH=CH 2, -C N N(R 24)C CH=CH 2, -C N N(R 24)C CH 2 Cl, X is aryl or heteroaryl; Y is a bond, -(C 1 -C 6)alkyl-, -O-(C 1 -C 6)alkyl-, aryl, or heteroaryl; Z is halogen, -(C 1 -C 12)alkyl, -(C 3 -C 7)cycloalkyl, aryl, or heteroaryl; -(C 3 -C 7)cycloalkyl, aryl, or heteroaryl; or, wherein X-Y-Z is each R 21 and R 22 is independently H, -(C 1 -C 6)alkyl, -(C 1 -C 6)heteroalkyl, -(C 1 -C 6)alkyl-CO 2 H, -C (C 1 -C 6)alkyl, -C N(R 31) 2, -SO 2 N(R 31) 2; or R 21 and R 22 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 31 is independently H or -(C 1 -C 6)alkyl; or two R 31 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 23 is independently H or -(C 1 -C 6)alkyl; each R 24 is independently H or -(C 1 -C 6)alkyl; each R 25 and R 26 is independently H or -(C 1 -C 6)alkyl; or R 25 and R 26 and the nitrogen atom to which they are attached form a heterocycloalkyl ring; each R 27 is independently halogen, -(C 1 -C 6)alkyl, or -(C 1 -C 6)heteroalkyl; each R 28 is independently halogen, -(C 1 -C 6)alkyl, or -(C 1 -C 6)heteroalkyl; R 29 is -CH 2 C NH 2 or aryl; R 30 is R 32 is H or -(C 1 -C 6)alkyl; R 33 is -CH 2 CN, -OC (C 1 -C 6)alkyl, or -SO 2 NH 2; R 34 is -OH, -NH 2, -CN, -CH 2 CH 2 CN, -O(C 1 -C 6)alkyl, -C (C 1 -C 6)alkyl, - SO 2 NH 2, p is 0, 1, or 2; and q is 0, 1, or 2; or a pharmaceutically acceptable salt or solvate thereof.