A knot placement device for applying a knot to a suture, the device comprising: an elongate body having a proximal end and a distal end, the elongate body further having a lumen extending from the proximal end to the distal end; a pusher rod slidably disposed within the elongate body; a cutting surface; and a handle coupled to the proximal end of the elongate body, the handle comprising: an elongate outer housing having a longitudinal axis, an actuator shaft, the pusher rod extending distally from the elongate outer housing and connected to the actuator shaft within the elongate outer housing, a first actuator with at least a portion extending outside the outer housing, wherein activating the first actuator is configured to advance the pusher rod of the knot placement device distally, a second actuator operably coupled to the actuator shaft, the second actuator configured to be translated to further advance the actuator shaft and push rod distally and to retract the actuator shaft and pusher rod proximally, a knob configured to be rotatable about the longitudinal axis, wherein rotating the knob causes rotation of the cutting surface, the outer housing having an aperture configured to allow a user to rotate the knob to cut the suture by rotating the cutting surface of the knot placement device, the knob having a resting position, and a friction mechanism operably coupled to the knob and imparting a force against the knob returning to the resting position when a user rotates the knob about the longitudinal axis in a first direction, wherein the friction mechanism prevents motion other than in the first direction, wherein advancing the pusher rod distally is configured to form a knot by advancing a plug into a knot body positioned within the elongate body to secure the suture therebetween and to eject the knot from the elongate body, and wherein retracting the pusher rod proximally is configured to release the cut suture. an elongate body having a proximal end and a distal end, the elongate body further having a lumen extending from the proximal end to the distal end; a pusher rod slidably disposed within the elongate body; a cutting surface; and a handle coupled to the proximal end of the elongate body, the handle comprising: an elongate outer housing having a longitudinal axis, an actuator shaft, the pusher rod extending distally from the elongate outer housing and connected to the actuator shaft within the elongate outer housing, a first actuator with at least a portion extending outside the outer housing, wherein activating the first actuator is configured to advance the pusher rod of the knot placement device distally, a second actuator operably coupled to the actuator shaft, the second actuator configured to be translated to further advance the actuator shaft and push rod distally and to retract the actuator shaft and pusher rod proximally, a knob configured to be rotatable about the longitudinal axis, wherein rotating the knob causes rotation of the cutting surface, the outer housing having an aperture configured to allow a user to rotate the knob to cut the suture by rotating the cutting surface of the knot placement device, the knob having a resting position, and a friction mechanism operably coupled to the knob and imparting a force against the knob returning to the resting position when a user rotates the knob about the longitudinal axis in a first direction, wherein the friction mechanism prevents motion other than in the first direction, an elongate outer housing having a longitudinal axis, an actuator shaft, the pusher rod extending distally from the elongate outer housing and connected to the actuator shaft within the elongate outer housing, a first actuator with at least a portion extending outside the outer housing, wherein activating the first actuator is configured to advance the pusher rod of the knot placement device distally, a second actuator operably coupled to the actuator shaft, the second actuator configured to be translated to further advance the actuator shaft and push rod distally and to retract the actuator shaft and pusher rod proximally, a knob configured to be rotatable about the longitudinal axis, wherein rotating the knob causes rotation of the cutting surface, the outer housing having an aperture configured to allow a user to rotate the knob to cut the suture by rotating the cutting surface of the knot placement device, the knob having a resting position, and a friction mechanism operably coupled to the knob and imparting a force against the knob returning to the resting position when a user rotates the knob about the longitudinal axis in a first direction, wherein the friction mechanism prevents motion other than in the first direction, wherein advancing the pusher rod distally is configured to form a knot by advancing a plug into a knot body positioned within the elongate body to secure the suture therebetween and to eject the knot from the elongate body, and wherein retracting the pusher rod proximally is configured to release the cut suture.