A compound of formula wherein A is CR 7 or N; U is CH or N; V is CR 8 or N; W is CR 9 or N; X is CH, CC 1-6 alkyl, COC 1-6 alkyl, or N; Yis CH or N; Z is CH, COH, COC 1-6 alkyl or N; R 1 is selected from the group consisting of H and halogen; R 2 is selected from the group consisting of H, C 1-6 alkyl, -CN, -CF 3, -OCF 3, C 3-6 cycloalkyl, OC 1-6 alkyl, and OC 3-6 cycloalkyl; when Z is COH, R 1 may join with the hydroxyl group attached to the Z ring atom to form a central furanyl ring; R 3 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with one to three groups independently selected from the group consisting of halogen, hydroxy or methoxy, and C 3-6 cycloalkyl; R 4 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with hydroxyl, C 3-6 cycloalkyl; R 5 is H or C 1-6 alkyl; R 3 and R 5 can together form a bicyclic ring; R 6 is selected from the group consisting of H, C 1-6 alkyl, -CN, -CF 3, -OCF 3, C 3-6 cycloalkyl, and OC 1-6 alkyl optionally substituted one to three halogen; R 7 is selected from the group consisting of H, C 1-6 alkyl, and OC 1-6 alkyl optionally substituted with one to three halogen; R 8 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, halogen, -CN, -CF 3, -NH 2, phenyl, C 3-6 cycloalkyl, OC 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with one to three halogen or C 3-6 cycloalkyl optionally substituted with one to three halogen; and 1-fluoromethyl-cyclopropylmethoxy; R 9 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with one to three halogen, halogen, -CN, -CF 3, OH, C 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, and OC 3-6 cycloalkyl; when V is CR 8 and W is CR 9, R 8 and R 9 can together form a 5- to 6-membered fused heterocyclic ring; or or a pharmaceutically acceptable salt thereof. A is CR 7 or N; U is CH or N; V is CR 8 or N; W is CR 9 or N; X is CH, CC 1-6 alkyl, COC 1-6 alkyl, or N; Yis CH or N; Z is CH, COH, COC 1-6 alkyl or N; R 1 is selected from the group consisting of H and halogen; R 2 is selected from the group consisting of H, C 1-6 alkyl, -CN, -CF 3, -OCF 3, C 3-6 cycloalkyl, OC 1-6 alkyl, and OC 3-6 cycloalkyl; when Z is COH, R 1 may join with the hydroxyl group attached to the Z ring atom to form a central furanyl ring; R 3 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with one to three groups independently selected from the group consisting of halogen, hydroxy or methoxy, and C 3-6 cycloalkyl; H, C 1-6 alkyl optionally substituted with one to three groups independently selected from the group consisting of halogen, hydroxy or methoxy, and C 3-6 cycloalkyl; R 4 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with hydroxyl, C 3-6 cycloalkyl; R 5 is H or C 1-6 alkyl; R 3 and R 5 can together form a bicyclic ring; R 6 is selected from the group consisting of H, C 1-6 alkyl, -CN, -CF 3, -OCF 3, C 3-6 cycloalkyl, and OC 1-6 alkyl optionally substituted one to three halogen; H, C 1-6 alkyl, -CN, -CF 3, -OCF 3, C 3-6 cycloalkyl, and OC 1-6 alkyl optionally substituted one to three halogen; R 7 is selected from the group consisting of H, C 1-6 alkyl, and OC 1-6 alkyl optionally substituted with one to three halogen; R 8 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, halogen, -CN, -CF 3, -NH 2, phenyl, C 3-6 cycloalkyl, OC 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with one to three halogen or C 3-6 cycloalkyl optionally substituted with one to three halogen; and 1-fluoromethyl-cyclopropylmethoxy; H, C 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, halogen, -CN, -CF 3, -NH 2, phenyl, C 3-6 cycloalkyl, OC 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with one to three halogen or C 3-6 cycloalkyl optionally substituted with one to three halogen; and 1-fluoromethyl-cyclopropylmethoxy; R 9 is selected from the group consisting of H, C 1-6 alkyl optionally substituted with one to three halogen, halogen, -CN, -CF 3, OH, C 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, and OC 3-6 cycloalkyl; H, C 1-6 alkyl optionally substituted with one to three halogen, halogen, -CN, -CF 3, OH, C 3-6 cycloalkyl, OC 1-6 alkyl optionally substituted with C 3-6 cycloalkyl or one to three halogen, and OC 3-6 cycloalkyl; when V is CR 8 and W is CR 9, R 8 and R 9 can together form a 5- to 6-membered fused heterocyclic ring; or or a pharmaceutically acceptable salt thereof.