mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing a divinylarene dioxide comprising the steps of: (a) feeding one or more feed streams of the following reactants into a reactor system: (i) at least one divinylarene, (ii) at least one oxidizing agent, and (iii) at least one solvent to form a reaction mixture in the reactor system; (b) continuously reacting together the one or more feed streams of the reactants of step (a) in the reaction mixture to form a divinylarene dioxide product; and (c) controlling heat removal of the reaction mixture as the reactants of step (b) react together via a reactor of the reactor system in step (b) having a surface area to volume ratio of greater than about 100 m 2 /m 3; wherein the residence time of the reactants in the reaction mixture in step (b) is less than about 180 minutes. (a) feeding one or more feed streams of the following reactants into a reactor system: (i) at least one divinylarene, (ii) at least one oxidizing agent, and (iii) at least one solvent to form a reaction mixture in the reactor system; (b) continuously reacting together the one or more feed streams of the reactants of step (a) in the reaction mixture to form a divinylarene dioxide product; and (c) controlling heat removal of the reaction mixture as the reactants of step (b) react together via a reactor of the reactor system in step (b) having a surface area to volume ratio of greater than about 100 m 2 /m 3; wherein the residence time of the reactants in the reaction mixture in step (b) is less than about 180 minutes.
A 2-alkyl- or 2-aromatic-substituted tanshinone I derivative of formula, which, when Z=R, represents 2-alkyl-substituted tanshinone I of formula I-1; when Z=Ar, represents 2-aryl-substituted tanshinone I of formula I-2; and when Z=Het, represents 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I of formula I-3, wherein R is selected from unsubstituted C 1 -C 18 alkyl, unsubstituted C 2 -C 18 alkenyl or alkynyl, and unsubstituted C 3 -C 7 cycloalkyl or cycloalkenyl; Ar is selected from substituted or unsubstituted aryl; and Het is selected from substituted or unsubstituted heteroaryl or heterocyclyl; each of the aforementioned substituted group is substituted by one or more substituents selected from the group consisting of halogen, amino, C 1 -C 6 substituted amino, nitro, cyano, C 1 -C 6 alkoxy, thiol, C 1 -C 6 alkylthio, or a water soluble functional group; wherein the water soluble functional group is selected from hydroxyl, polyhydroxy alkoxy, saccharide residue, carboxyl, sulfonic acid group, phosphate group, polyhydroxy alkoxy carbonyl, carboxyl alkoxy, and carboxyl alkyl formyloxy, wherein the alkoxy and alkyl in the aforementioned groups have 1-8 carbon atoms, respectively; and Ar may further be substituted with C 1 -C 6 alkyl; or a pharmaceutically acceptable salt thereof. when Z=R, represents 2-alkyl-substituted tanshinone I of formula I-1; when Z=Ar, represents 2-aryl-substituted tanshinone I of formula I-2; and when Z=Het, represents 2-heteroaryl- or 2-heterocyclyl-substituted tanshinone I of formula I-3, R is selected from unsubstituted C 1 -C 18 alkyl, unsubstituted C 2 -C 18 alkenyl or alkynyl, and unsubstituted C 3 -C 7 cycloalkyl or cycloalkenyl; Ar is selected from substituted or unsubstituted aryl; and Het is selected from substituted or unsubstituted heteroaryl or heterocyclyl; each of the aforementioned substituted group is substituted by one or more substituents selected from the group consisting of halogen, amino, C 1 -C 6 substituted amino, nitro, cyano, C 1 -C 6 alkoxy, thiol, C 1 -C 6 alkylthio, or a water soluble functional group; wherein the water soluble functional group is selected from hydroxyl, polyhydroxy alkoxy, saccharide residue, carboxyl, sulfonic acid group, phosphate group, polyhydroxy alkoxy carbonyl, carboxyl alkoxy, and carboxyl alkyl formyloxy, wherein the alkoxy and alkyl in the aforementioned groups have 1-8 carbon atoms, respectively; and Ar may further be substituted with C 1 -C 6 alkyl;
Pressure indication device for indicating a pressure in a first fluidic system, which pressure indication device has a first connection for fluidically connecting it to the first system, the pressure indication device further comprises a cylinder that houses a piston which latter is biased in the axial direction and can be moved within the cylinder, with a fluid contained in the first fluidic system being capable of acting on the piston surface, which piston has an opening in its piston surface which opening can be connected to a second system for communication therewith, by means of a second connection, characterized in that the piston comprises a diaphragm which is impermeable to a first fluid but permeable to a second fluid, which diaphragm separates the first connection from the second connection, which diaphragm is impermeable to a liquid and permeable to a gas or a gaseous mixture.
A method comprising: (a) forming a molten liquid from silicon; (b) forming a solidified silicon at a top portion of the molten liquid; (c) placing a glass on top of the solidified silicon; (d) heating the solidified silicon and the glass, sufficient to melt the solidified silicon back into the molten liquid and to melt the glass so that the glass forms a molten glass layer on top of the molten liquid; and (e) allowing the molten liquid to directionally solidify, from the bottom portion of the molten liquid toward the molten glass layer, to provide solid silicon. (a) forming a molten liquid from silicon; (b) forming a solidified silicon at a top portion of the molten liquid; (c) placing a glass on top of the solidified silicon; (d) heating the solidified silicon and the glass, sufficient to melt the solidified silicon back into the molten liquid and to melt the glass so that the glass forms a molten glass layer on top of the molten liquid; and (e) allowing the molten liquid to directionally solidify, from the bottom portion of the molten liquid toward the molten glass layer, to provide solid silicon.
An in vitro method for preparing a circular double-stranded nucleic acid vector, the method comprising: contacting a parent nucleic acid comprising: (a) an expression cassette comprising a promoter operably linked to a sequence encoding a protein and flanked by attB and attP sites recognised by a unidirectional site-specific φC31 integrase; and (b) a coding sequence for the unidirectional site-specific φC31 integrase under the control of an inducible promoter; with an inducer of the inducible promoter under conditions sufficient to produce the circular double-stranded nucleic acid vector. contacting a parent nucleic acid comprising: (a) an expression cassette comprising a promoter operably linked to a sequence encoding a protein and flanked by attB and attP sites recognised by a unidirectional site-specific φC31 integrase; and (b) a coding sequence for the unidirectional site-specific φC31 integrase under the control of an inducible promoter; (a) an expression cassette comprising a promoter operably linked to a sequence encoding a protein and flanked by attB and attP sites recognised by a unidirectional site-specific φC31 integrase; and (b) a coding sequence for the unidirectional site-specific φC31 integrase under the control of an inducible promoter; with an inducer of the inducible promoter under conditions sufficient to produce the circular double-stranded nucleic acid vector.
A method for determining a likely effect of a treatment to improve male fertility, the method comprising • determining the level of OPG in a blood serum sample, which has been obtained from a male subject; • comparing said determined OPG level to a reference level; and • determining that said subject will ∘ likely not benefit from treatment with an antagonist or inhibitor of RANKL, if said level is lower than said reference level, or ∘ likely benefit from treatment with an antagonist or inhibitor of RANKL, if said level is equal to higher than said reference level; wherein said reference level is above 3 pmol/l OPG in blood serum. • determining the level of OPG in a blood serum sample, which has been obtained from a male subject; • comparing said determined OPG level to a reference level; and • determining that said subject will ∘ likely not benefit from treatment with an antagonist or inhibitor of RANKL, if said level is lower than said reference level, or ∘ likely benefit from treatment with an antagonist or inhibitor of RANKL, if said level is equal to higher than said reference level; ∘ likely not benefit from treatment with an antagonist or inhibitor of RANKL, if said level is lower than said reference level, or ∘ likely benefit from treatment with an antagonist or inhibitor of RANKL, if said level is equal to higher than said reference level;
A chain connector for use with a tailgate chain linkage of a machine, the chain connector comprising: a first flange, a second flange and a web extending between the first flange and the second flange; the first flange and the second flange each having a first end and a second end; the first flange and the second flange comprising pairs of apertures (26, 27), wherein each pair of apertures (26, 27) comprises a first aperture in the first flange and a second aperture in the second flange with the first aperture and second aperture of each pair of apertures (26, 27) being aligned with each other; the pairs of apertures (26, 27) comprising a first pair of apertures disposed in the first ends of the first flange and the second flange for coupling the chain connector to an attachment plate of the machine, and a plurality of second pairs of apertures disposed in the second ends of the first flange and the second flange for coupling the chain connector to a chain of the chain linkage; wherein the plurality of second pairs of apertures are disposed at a plurality of distances (d 1 -d 7) from the first pair of apertures whereby an effective length of the tailgate chain linkage may be adjusted by coupling the chain of the chain linkage with a selected second pair of apertures of the plurality of second pairs of apertures. a first flange, a second flange and a web extending between the first flange and the second flange; the first flange and the second flange each having a first end and a second end; the first flange and the second flange comprising pairs of apertures (26, 27), wherein each pair of apertures (26, 27) comprises a first aperture in the first flange and a second aperture in the second flange with the first aperture and second aperture of each pair of apertures (26, 27) being aligned with each other; the pairs of apertures (26, 27) comprising a first pair of apertures disposed in the first ends of the first flange and the second flange for coupling the chain connector to an attachment plate of the machine, and a plurality of second pairs of apertures disposed in the second ends of the first flange and the second flange for coupling the chain connector to a chain of the chain linkage; wherein the plurality of second pairs of apertures are disposed at a plurality of distances (d 1 -d 7) from the first pair of apertures whereby an effective length of the tailgate chain linkage may be adjusted by coupling the chain of the chain linkage with a selected second pair of apertures of the plurality of second pairs of apertures.
A cyclosporin conjugate which is a compound of formula or a pharmaceutically acceptable salt thereof: in which: - A represents - B represents methyl or ethyl, - R 2 represents ethyl or isopropyl, - R 4 represents -CH 2 CH(CH 3)CH 3, -CH 2 CH(CH 3)CH 2 CH 3, -CH(CH 3)CH 3 or - CH(CH 3)CH 2 CH 3, - either (a) one of R 1 and R 1 * represents -L 1 Z 1 and the other represents hydrogen, and R 3 represents hydrogen, C 1 -C 3 alkyl or C 2 -C 4 alkenyl, or (b) one of R 1 and R 1 * represents methyl and the other represents hydrogen, and R 3 represents -L 3 Z 3, or (c) one of R 1 and R 1 * represents -L 1 Z 1 and the other represents hydrogen, and R 3 represents -L 3 Z 3, - L 1 and L 3 independently represent a C 1 -C 6 alkylene moiety, a C 2 -C 6 alkenylene moiety or a -(CH 2 CH 2 O) n (CH 2) m - moiety in which n represents 1 to 3 and m represents 0 to 2, and - Z 1 and Z 3 independently represent a moiety of formula (II*): in which Q 1 * to Q 7 * independently represent a hydrogen atom, a C 1 -C 6 haloalkyl group, a -OR' group, or a -NR'R" group, wherein R' and R" are the same or different and represent hydrogen or a C 1 -C 6 alkyl group, and wherein four to seven of Q 1 * to Q 7 * represent hydrogen. - A represents - B represents methyl or ethyl, - R 2 represents ethyl or isopropyl, - R 4 represents -CH 2 CH(CH 3)CH 3, -CH 2 CH(CH 3)CH 2 CH 3, -CH(CH 3)CH 3 or - CH(CH 3)CH 2 CH 3, - either (a) one of R 1 and R 1 * represents -L 1 Z 1 and the other represents hydrogen, and R 3 represents hydrogen, C 1 -C 3 alkyl or C 2 -C 4 alkenyl, or (b) one of R 1 and R 1 * represents methyl and the other represents hydrogen, and R 3 represents -L 3 Z 3, or (c) one of R 1 and R 1 * represents -L 1 Z 1 and the other represents hydrogen, and R 3 represents -L 3 Z 3, - L 1 and L 3 independently represent a C 1 -C 6 alkylene moiety, a C 2 -C 6 alkenylene moiety or a -(CH 2 CH 2 O) n (CH 2) m - moiety in which n represents 1 to 3 and m represents 0 to 2, and - Z 1 and Z 3 independently represent a moiety of formula (II*): in which Q 1 * to Q 7 * independently represent a hydrogen atom, a C 1 -C 6 haloalkyl group, a -OR' group, or a -NR'R" group, wherein R' and R" are the same or different and represent hydrogen or a C 1 -C 6 alkyl group, and wherein four to seven of Q 1 * to Q 7 * represent hydrogen.
A packaging apparatus, at least comprising: - a transport section or staging location for articles, - a packaging station for packaging articles by transferring a plurality of articles into outer packagings, which can each accommodate at least one article group composed of a plurality of articles, - at least one manipulator that is movable between the transport section or staging location and the packaging station, the manipulator being configured to seize an article group and insert or place it into an outer packaging staged at the packaging station, and - at least one direct-printing station situated between the transport section or staging location and the packaging station and being within reach of the at least one manipulator together with the article group, the direct-printing station having a stationary direct printhead within reach of the manipulator, which direct printhead is configured to apply printing ink at least on one location of the particular outsides of the articles that are seized, held, and being moved past the direct printhead by the manipulator in order to be printed on, or at least of one article that is seized, held, and being moved past the direct printhead by the manipulator in order to be printed on. - a transport section or staging location for articles, - a packaging station for packaging articles by transferring a plurality of articles into outer packagings, which can each accommodate at least one article group composed of a plurality of articles, - at least one manipulator that is movable between the transport section or staging location and the packaging station, the manipulator being configured to seize an article group and insert or place it into an outer packaging staged at the packaging station, and - at least one direct-printing station situated between the transport section or staging location and the packaging station and being within reach of the at least one manipulator together with the article group, the direct-printing station having a stationary direct printhead within reach of the manipulator, which direct printhead is configured to apply printing ink at least on one location of the particular outsides of the articles that are seized, held, and being moved past the direct printhead by the manipulator in order to be printed on, or at least of one article that is seized, held, and being moved past the direct printhead by the manipulator in order to be printed on.
A downhole cleaning tool for removing residues or precipitation solids on an inner face of a casing or a liner, comprising: - a tool body having a bore and a wall, - at least one inlet in the wall of the tool body, said inlet being fluidly connected with the bore, - a solid removing element connected with the tool body for releasing solids of the inner face of the casing or the liner, and - a fluid cleaner section comprising: - a chamber, - a filter within the chamber for separation of the solids from the fluid, and - a pump fluidly connected with the bore for sucking fluid with released solids in through the inlet into the chamber, wherein the solid removing element comprises at least one projecting part projecting from the tool body and a spring arranged between the tool body and the projecting part, and wherein the at least one inlet is arranged adjacent the at least one projecting part for suction of released solids. - a tool body having a bore and a wall, - at least one inlet in the wall of the tool body, said inlet being fluidly connected with the bore, - a solid removing element connected with the tool body for releasing solids of the inner face of the casing or the liner, and - a fluid cleaner section comprising: - a chamber, - a filter within the chamber for separation of the solids from the fluid, and - a pump fluidly connected with the bore for sucking fluid with released solids in through the inlet into the chamber, - a chamber, - a filter within the chamber for separation of the solids from the fluid, and - a pump fluidly connected with the bore for sucking fluid with released solids in through the inlet into the chamber,
Adjusting member to compensate a gap between a support and a part to be fixed on the support, comprising a hollow body provided with an external thread in a first thread direction, characterized in that the hollow body comprises an internal thread having a second thread direction opposite to the first one, the internal thread comprising at least two threads (13, 14), and at least one thread (13, 14) is deformed to supply a higher friction torque than that supplied by the other threads of the internal thread.
A process for continuously preparing nitrated aromatics by reacting at least one aromatic with a mixture comprising nitric acid, sulfuric acid and water, comprising the steps of (a) feeding the at least one aromatic and the mixture comprising nitric acid, sulfuric acid and water in any sequence into a tubular reactor, said tubular reactor having a plurality of vertical tube bends with a deflection angle in the range from 160° to 200°, which are arranged over the total length of the reactor at a distance which corresponds to 30 to 70 times the diameter of the reactor, and a number of static mixing elements which are arranged such that conditions under which the Bodenstein number assumes a value or values greater than 5 exist that in a first part of the tubular reactor and conditions under which the Bodenstein number assumes a value or values greater than 5 exist in a second part of the reactor, (b) converting the reaction mixture in the reactor under adiabatic conditions in order to obtain a reaction mixture, and (c) separating the reaction mixture obtained in step (b) after performance of the reaction into an organic phase and an aqueous phase. (a) feeding the at least one aromatic and the mixture comprising nitric acid, sulfuric acid and water in any sequence into a tubular reactor, said tubular reactor having a plurality of vertical tube bends with a deflection angle in the range from 160° to 200°, which are arranged over the total length of the reactor at a distance which corresponds to 30 to 70 times the diameter of the reactor, and a number of static mixing elements which are arranged such that conditions under which the Bodenstein number assumes a value or values greater than 5 exist that in a first part of the tubular reactor and conditions under which the Bodenstein number assumes a value or values greater than 5 exist in a second part of the reactor, (b) converting the reaction mixture in the reactor under adiabatic conditions in order to obtain a reaction mixture, and (c) separating the reaction mixture obtained in step (b) after performance of the reaction into an organic phase and an aqueous phase.
A tire in which a plurality of land portions are defined in a tread surface by a plurality of circumferential grooves extending in a tire circumferential direction, and each of the plurality of land portions has a plurality of lateral grooves crossing the land portion, wherein the plurality of lateral grooves are arranged so that, when the plurality of lateral grooves are projected onto a tire equatorial plane, lateral grooves adjacent in the tire circumferential direction do not overlap each other, each of the plurality of lateral grooves is made up of a center region extending at an angle of inclination relative to a tread width direction and side regions extending from both ends of the center region toward respective circumferential grooves at a smaller angle of inclination relative to the tread width direction than the center region, the side regions increasing in groove width toward the respective circumferential grooves, and each of the plurality of lateral grooves has a sipe leading inward in a tire radial direction from a groove bottom of the lateral groove, and the sipe has, only in the center region, a shallow portion (p) with a smaller depth, characterized in that the shallow portion (p) is located at least near a boundary part (f) between the center region and each of the side regions with a starting point (pst) of the shallow portion (p) being apart from the boundary part (f).
A composition comprising: a polycarbonate component comprising a repeating unit comprising an electrophilic side chain the repeating unit having a structure wherein R 1 has the structure: wherein each R 2 is independently chosen from: and -H, wherein at least one R 2 is an ester, and wherein R 3 is (C 1 -C 10) alkyl; a carbon fiber component comprising an activated surface wherein the activated surface comprises a nucleophilic group selected from the group consisting of, a hydroxy group, a carboxyl group, an amino group, and a combination thereof; and an interface between the polycarbonate component and the carbon fiber component. a polycarbonate component comprising a repeating unit comprising an electrophilic side chain the repeating unit having a structure wherein R 1 has the structure: wherein each R 2 is independently chosen from: and -H, wherein at least one R 2 is an ester, and wherein R 3 is (C 1 -C 10) alkyl; a carbon fiber component comprising an activated surface wherein the activated surface comprises a nucleophilic group selected from the group consisting of, a hydroxy group, a carboxyl group, an amino group, and a combination thereof; and an interface between the polycarbonate component and the carbon fiber component.
Moulding element of a mould for moulding and vulcanizing a tyre tread, this tread comprising a tread surface intended to come into contact with the ground when the said tyre is rolling, this moulding element comprising a moulding surface intended to mould part of the tyre tread surface and a blade intended to mould a sipe or a groove in the tread, characterized in that the moulding element comprises two lamella positioned on either side of the blade at a certain distance from this blade, each lamella comprising a bulge at one extremity far away from the moulding surface and in that each lamella comprises cutting means extending from the bulge.