A medical tube comprising: a tube wall defining a passageway for transportation of gas, and having a first end and a second end, the passageway providing for fluid communication between the ends, wherein at least one end of the medical tube comprises: a cuff over-moulded about and attaching of one or more first pre-formed component(s), one or more second pre-formed component(s), and at least a portion of the at least one tube end, such that in use, the first pre-formed component or components is in fluid communication with the passageway, the, or each, first pre-formed component configured for fluid connection with a further component(s) of a breathing circuit, and the second pre-formed component or components is receivable of at least one auxiliary medical tube appliance, wherein: the second pre-formed component is located longitudinally intermediate of the at least one end of the tube and the first pre-formed component and wherein the cuff: forms a pneumatic seal about the at least one tube end and between the first pre-formed component(s) and the second pre-formed component(s), whilst maintaining fluid connection between the first pre-formed component(s) and the at least one end of the tube and passageway therein; and is directly attached by over-moulding to an exterior surface of the at least one end of the tube and the or each of the first pre-formed component(s) and the or each of the second pre-formed component(s). a tube wall defining a passageway for transportation of gas, and having a first end and a second end, the passageway providing for fluid communication between the ends, wherein at least one end of the medical tube comprises: a cuff over-moulded about and attaching of one or more first pre-formed component(s), one or more second pre-formed component(s), and at least a portion of the at least one tube end, such that in use, the first pre-formed component or components is in fluid communication with the passageway, the, or each, first pre-formed component configured for fluid connection with a further component(s) of a breathing circuit, and the second pre-formed component or components is receivable of at least one auxiliary medical tube appliance, wherein: the second pre-formed component is located longitudinally intermediate of the at least one end of the tube and the first pre-formed component and wherein the cuff: forms a pneumatic seal about the at least one tube end and between the first pre-formed component(s) and the second pre-formed component(s), whilst maintaining fluid connection between the first pre-formed component(s) and the at least one end of the tube and passageway therein; and is directly attached by over-moulding to an exterior surface of the at least one end of the tube and the or each of the first pre-formed component(s) and the or each of the second pre-formed component(s). a cuff over-moulded about and attaching of one or more first pre-formed component(s), one or more second pre-formed component(s), and at least a portion of the at least one tube end, such that in use, the first pre-formed component or components is in fluid communication with the passageway, the, or each, first pre-formed component configured for fluid connection with a further component(s) of a breathing circuit, and the second pre-formed component or components is receivable of at least one auxiliary medical tube appliance, wherein: the second pre-formed component is located longitudinally intermediate of the at least one end of the tube and the first pre-formed component and wherein the cuff: forms a pneumatic seal about the at least one tube end and between the first pre-formed component(s) and the second pre-formed component(s), whilst maintaining fluid connection between the first pre-formed component(s) and the at least one end of the tube and passageway therein; and is directly attached by over-moulding to an exterior surface of the at least one end of the tube and the or each of the first pre-formed component(s) and the or each of the second pre-formed component(s). forms a pneumatic seal about the at least one tube end and between the first pre-formed component(s) and the second pre-formed component(s), whilst maintaining fluid connection between the first pre-formed component(s) and the at least one end of the tube and passageway therein; and is directly attached by over-moulding to an exterior surface of the at least one end of the tube and the or each of the first pre-formed component(s) and the or each of the second pre-formed component(s).