mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a therapeutically effective amount of pemafibrate or a pharmaceutically acceptable salt thereof, and optionally pharmaceutically acceptable carrier or excipient, for use in a method of preventing the occurrence of cardiovascular events in a patient with one or more cardiovascular risk factors, wherein: a) the patient has type 2 diabetes mellitus; b) the patient has a fasting TG concentration ≥ 200 mg/dL and < 500 mg/dL; c) the patient has an HDL-C concentration ≤ 40 mg/dL; d) the patient is: i) on concomitant moderate to high intensity statin therapy; ii) on concomitant lipid-lowering therapy other than the concomitant moderate to high intensity statin therapy and has an LDL-C concentration ≤ 70 mg/dL; or iii) statin-intolerant and has an LDL-C concentration ≤ 100 mg/dL; e) the patient has an age greater than or equal to 50 years if male or 55 years if female without systemic atherosclerosis, or systemic atherosclerosis; f) the therapeutically effective amount of pemafibrate or pharmaceutically acceptable salt thereof is 0.4 mg, administered orally per day; and g) the cardiovascular events are selected from nonfatal myocardial infarction, nonfatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization, cardiovascular death, or a combination thereof. a) the patient has type 2 diabetes mellitus; b) the patient has a fasting TG concentration ≥ 200 mg/dL and < 500 mg/dL; c) the patient has an HDL-C concentration ≤ 40 mg/dL; d) the patient is: i) on concomitant moderate to high intensity statin therapy; ii) on concomitant lipid-lowering therapy other than the concomitant moderate to high intensity statin therapy and has an LDL-C concentration ≤ 70 mg/dL; or iii) statin-intolerant and has an LDL-C concentration ≤ 100 mg/dL; i) on concomitant moderate to high intensity statin therapy; ii) on concomitant lipid-lowering therapy other than the concomitant moderate to high intensity statin therapy and has an LDL-C concentration ≤ 70 mg/dL; or iii) statin-intolerant and has an LDL-C concentration ≤ 100 mg/dL; e) the patient has an age greater than or equal to 50 years if male or 55 years if female without systemic atherosclerosis, or systemic atherosclerosis; f) the therapeutically effective amount of pemafibrate or pharmaceutically acceptable salt thereof is 0.4 mg, administered orally per day; and g) the cardiovascular events are selected from nonfatal myocardial infarction, nonfatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization, cardiovascular death, or a combination thereof.
A computer program comprising instructions which, when executed on at least one processor of a computer device for use in material processing of a two dimensional sheet like material, cause the at least one processor to carry out: obtaining information related to a desired design of a three dimensional obj ect; obtaining information related to material characteristics of the two dimensional sheet like material; defining a primary surface and a secondary surface of the desired design of the three dimensional object; and defining a geometrical relationship between said primary surface and secondary surface; wherein the secondary surface is a reflection of the primary surface in a two dimensional plane, and wherein when said primary surface is concave said secondary surface is convex, or when said primary surface is convex said secondary surface is concave; and providing, or otherwise creating, a digital instruction for a fully developed spreading and subsequent folding of a two dimensional sheet into the obtained desired design of the three dimensional object, wherein said digital instruction is based on the defined primary and secondary surfaces, respectively, and said obtained material characteristics. obtaining information related to a desired design of a three dimensional obj ect; obtaining information related to material characteristics of the two dimensional sheet like material; defining a primary surface and a secondary surface of the desired design of the three dimensional object; and defining a geometrical relationship between said primary surface and secondary surface; wherein the secondary surface is a reflection of the primary surface in a two dimensional plane, and wherein when said primary surface is concave said secondary surface is convex, or when said primary surface is convex said secondary surface is concave; and the secondary surface is a reflection of the primary surface in a two dimensional plane, and wherein when said primary surface is concave said secondary surface is convex, or when said primary surface is convex said secondary surface is concave; and providing, or otherwise creating, a digital instruction for a fully developed spreading and subsequent folding of a two dimensional sheet into the obtained desired design of the three dimensional object, wherein said digital instruction is based on the defined primary and secondary surfaces, respectively, and said obtained material characteristics.
An apparatus (100; 150; 903; 2100) comprising: a plurality of processor cores (102a-N; 902a-f) to execute a plurality of processes; a register (200; 300; 400) to store an indicator (120; 124) that is to indicate a preference for either performance or energy efficiency; a first circuitry to determine an effective utilization of a first processor core, based at least in part on the indicator (120; 124), wherein the first circuitry is to: select, as the effective utilization of the first processor core, a utilization of a first process, in response to the indicator (120; 124) having an indication for a preference for performance, wherein the first processor core is to at least in part execute the first process, and wherein the utilization of the first process is the utilization or active state residency time of the first process, and select, as the effective utilization of the first processor core, a utilization of the first processor core, in response to the indicator having an indication for a preference for energy efficiency; and a second circuitry (110; 119) to select at least one of an operating voltage or an operating frequency for the first processor core, based at least in part on the effective utilization of the first processor core. a plurality of processor cores (102a-N; 902a-f) to execute a plurality of processes; a register (200; 300; 400) to store an indicator (120; 124) that is to indicate a preference for either performance or energy efficiency; a first circuitry to determine an effective utilization of a first processor core, based at least in part on the indicator (120; 124), wherein the first circuitry is to: select, as the effective utilization of the first processor core, a utilization of a first process, in response to the indicator (120; 124) having an indication for a preference for performance, wherein the first processor core is to at least in part execute the first process, and wherein the utilization of the first process is the utilization or active state residency time of the first process, and select, as the effective utilization of the first processor core, a utilization of the first processor core, in response to the indicator having an indication for a preference for energy efficiency; and select, as the effective utilization of the first processor core, a utilization of a first process, in response to the indicator (120; 124) having an indication for a preference for performance, wherein the first processor core is to at least in part execute the first process, and wherein the utilization of the first process is the utilization or active state residency time of the first process, and select, as the effective utilization of the first processor core, a utilization of the first processor core, in response to the indicator having an indication for a preference for energy efficiency; and a second circuitry (110; 119) to select at least one of an operating voltage or an operating frequency for the first processor core, based at least in part on the effective utilization of the first processor core.
An FGF-18 compound for use in the treatment of a cartilage disorder wherein the FGF-18 compound is to be administered intra-articularly at least three times per treatment cycle, said administrations being separated by about 3, 4 or 5 weeks.
An internal combustion engine body comprising: a cylinder block including a first water jacket and a second water jacket that are provided around a plurality of cylinders; and a cylinder head including an in-head water jacket, wherein the in-head water jacket includes an intake-side flow passage that communicates with the first water jacket and the second water jacket and that is provided around an intake port, at least part of the first water jacket is provided on intake sides of the plurality of the cylinders, at least part of the second water jacket is provided on exhaust sides of the plurality of the cylinders, the first water jacket has an inflow port into which coolant flows from an outside of the internal combustion engine body, the cylinder block and the cylinder head are provided such that a flow rate of the coolant that directly flows into the intake-side flow passage after flowing into the first water jacket is higher than a flow rate of the coolant directly flows into any region other than the intake-side flow passage after flowing into the first water jacket, and each of the intake sides is a side where the intake port is provided with respect to a plane containing axes of the plurality of the cylinders in a direction perpendicular to the plane, and each of the exhaust sides is a side where an exhaust port is provided with respect to the plane, characterised in that the first water jacket and the second water jacket are provided in such a manner as not to directly communicate with each other. a cylinder block including a first water jacket and a second water jacket that are provided around a plurality of cylinders; and a cylinder head including an in-head water jacket, wherein the in-head water jacket includes an intake-side flow passage that communicates with the first water jacket and the second water jacket and that is provided around an intake port, at least part of the first water jacket is provided on intake sides of the plurality of the cylinders, at least part of the second water jacket is provided on exhaust sides of the plurality of the cylinders, the first water jacket has an inflow port into which coolant flows from an outside of the internal combustion engine body, the cylinder block and the cylinder head are provided such that a flow rate of the coolant that directly flows into the intake-side flow passage after flowing into the first water jacket is higher than a flow rate of the coolant directly flows into any region other than the intake-side flow passage after flowing into the first water jacket, and each of the intake sides is a side where the intake port is provided with respect to a plane containing axes of the plurality of the cylinders in a direction perpendicular to the plane, and each of the exhaust sides is a side where an exhaust port is provided with respect to the plane, characterised in that the first water jacket and the second water jacket are provided in such a manner as not to directly communicate with each other.
A variant of a LovD polypeptide having at least 85% sequence identity with the amino acid sequence shown in SEQ ID NO:1 and having LovD acyltransferase activity, the variant LovD polypeptide comprising amino acid substitutions C40A; C60N; and A86V.
A biocompatible synthetic macromer composition comprising a first polymer of formula H 2 N-[R 1 -Q-R 2]-NH 2 where R 1 and R 2 are the same or different and can be alkoxy or alkoxy with bioabsorbable groups, and Q is selected from the group consisting of phthalic, bisphenol A, biphenyl, diglycidyl ethers of bisphenol A, ethoxylated bisphenol A, terephthalic acid, phenylene diamines, toluene diamine, imides; and, characterised by a second component having amine-reactive groups is of the formula R 3 n wherein n>1, X is selected from the group consisting of succinimidyl groups, isocyanate groups, and combinations thereof, and R 3 is selected from the group consisting of sorbitol, mannitol, dextran, cyclodextrin, polyalkylene oxides, polyethylene glycols with lactide linkages, and polyethylene oxide copolymers with polypropylene oxide where R 1 and R 2 are the same or different and can be alkoxy or alkoxy with bioabsorbable groups, and Q is selected from the group consisting of phthalic, bisphenol A, biphenyl, diglycidyl ethers of bisphenol A, ethoxylated bisphenol A, terephthalic acid, phenylene diamines, toluene diamine, imides; wherein n>1, X is selected from the group consisting of succinimidyl groups, isocyanate groups, and combinations thereof, and R 3 is selected from the group consisting of sorbitol, mannitol, dextran, cyclodextrin, polyalkylene oxides, polyethylene glycols with lactide linkages, and polyethylene oxide copolymers with polypropylene oxide
Window with a casement pivotable about a frame, with a connecting rod fitting for bolting the casement in the frame, with two pivot bearings supporting the casement, wherein one of the pivot bearings is arranged on an upper horizontal beam of the casement and the pivot bearing respectively has a frame-side fitting part and a casement-side fitting part and two control levers connecting the fitting parts, wherein the upper horizontal beam of the casement is hinged via a folding bearing arranged at a distance from the upper pivot bearing with a horizontal bearing axis on the frame and the upper pivot bearing also has a folding bearing with a horizontal axis, characterized in that the lower pivot bearing has an extension arm for supporting the casement in a position folded away around the horizontal bearing axis of the folding bearings (11, 12), in that the folding bearing has a support element with a support rack, and in that the support rack has a ramp in the direction of rotation of the casement, and in that a pin connected with the casement rests in locking position and in folding position on the ramp, in that a second support element is arranged below the upper pivot bearing, and in that the second support element has a rod, and in that the rod supports itself with its ends on a casement-side fitting part and a support rack arranged on the frame.
Combination of electric machine and cooling system of said electric machine comprising a stator and a rotor, said cooling system comprising: - a cooling circuit able to bring an oil-type cooling liquid into contact with active parts of said electric machine, - a tank able to collect the cooling liquid that has cooled said active parts, - a pump able to reinject said cooling liquid upstream of said active parts, - and a heat exchanger, combination in which said cooling circuit comprises a bypass branch able to deviate some of the cooling liquid circulating upstream of said active parts and to cause it to pass directly into the tank without passing through said active parts, said cooling system comprising means for opening and for closing said bypass branch as a function of a temperature threshold of the cooling liquid or a temperature threshold of the rotor and/or a temperature threshold of the stator, said opening and closing means being a solenoid valve controlled by an electronic control unit or a thermostat, able to allow cooling liquid to pass into said bypass branch as soon as the temperature of the cooling liquid becomes greater than said temperature threshold and able to prevent the cooling liquid from passing into said bypass branch as soon as the temperature is lower than said threshold, said threshold being between 30 and 50°C. - a cooling circuit able to bring an oil-type cooling liquid into contact with active parts of said electric machine, - a tank able to collect the cooling liquid that has cooled said active parts, - a pump able to reinject said cooling liquid upstream of said active parts, - and a heat exchanger,
A nacelle assembly for a gas turbine engine comprising: a core nacelle defined about an engine centerline axis; a fan nacelle mounted at least partially around said core nacelle to define a fan bypass flow path; a variable area fan nozzle in communication with said fan bypass flow path, said variable area fan nozzle having a first fan nacelle section and a second fan nacelle section; and an actuator assembly operable to move said second fan nacelle section relative to said first fan nacelle section to vary a fan nozzle exit area and adjust fan bypass airflow; characterised in that said actuator assembly extends at least partially into said fan bypass flow path. a core nacelle defined about an engine centerline axis; a fan nacelle mounted at least partially around said core nacelle to define a fan bypass flow path; a variable area fan nozzle in communication with said fan bypass flow path, said variable area fan nozzle having a first fan nacelle section and a second fan nacelle section; and an actuator assembly operable to move said second fan nacelle section relative to said first fan nacelle section to vary a fan nozzle exit area and adjust fan bypass airflow; characterised in that said actuator assembly extends at least partially into said fan bypass flow path.
A solder paste for use with a reducing gas during soldering, essentially consisting of: a solder powder; a thixotropic agent that is solid at normal temperature, wherein the thixotropic agent is one or more of: a compound containing an amide bond, a compound containing a polyamide obtained by condensation polymerization of a diamine with a dicarboxylic acid, sorbitol, a benzylidene sorbitol, hardened castor oil, beeswax and carnauba wax; and a solvent for dispersing the solder powder and thixotropic agent, imparting a structural viscosity to gelate the solder paste, and allowing viscosity adjustment, wherein percentage compositions of the solder powder, the thixotropic agent and the solvent are 80 to 99% by mass of the solder powder, 0.1 to 2% by mass of the thixotropic agent and 0.9 to 18% by mass of the solvent, the solder paste is free of reducing agents for removal of oxide films and free of activators for improvement of reducibility, and the solvent shows a weight loss of 25% or more at a rate of temperature increase of 10°C/min in thermogravimetry under normal pressure at 180°C. a solder powder; a thixotropic agent that is solid at normal temperature, wherein the thixotropic agent is one or more of: a compound containing an amide bond, a compound containing a polyamide obtained by condensation polymerization of a diamine with a dicarboxylic acid, sorbitol, a benzylidene sorbitol, hardened castor oil, beeswax and carnauba wax; and a solvent for dispersing the solder powder and thixotropic agent, imparting a structural viscosity to gelate the solder paste, and allowing viscosity adjustment, wherein percentage compositions of the solder powder, the thixotropic agent and the solvent are 80 to 99% by mass of the solder powder, 0.1 to 2% by mass of the thixotropic agent and 0.9 to 18% by mass of the solvent, the solder paste is free of reducing agents for removal of oxide films and free of activators for improvement of reducibility, and the solvent shows a weight loss of 25% or more at a rate of temperature increase of 10°C/min in thermogravimetry under normal pressure at 180°C.
A fuel injection system for a piston engine, the fuel injection system comprising - at least one low-pressure pump (7, 7a, 7b, 7c) for raising the pressure of fuel to a first pressure level, - at least one high-pressure pump (5, 5a, 5b, 5c) for raising the pressure of the fuel from the first pressure level to a second pressure level that is higher than the first pressure level, - a fuel accumulator (4, 4a, 4b, 4c) that is connected to the high-pressure pump(s) (5, 5a, 5b, 5c) for receiving fuel at the second pressure level, - a fuel injector that is connected to the fuel accumulator (4, 4a, 4b, 4c) for receiving pressurized fuel from the fuel accumulator (4, 4a, 4b, 4c) and for injecting the fuel into a cylinder of the engine, and - at least two flow control valves (6a, 6b, 6c, 6d, 6e, 6f), each of the flow control valves (6a, 6b, 6c, 6d, 6e, 6f) being arranged between the at least one low-pressure pump (7, 7a, 7b, 7c) and the at least one high-pressure pump (5, 5a, 5b, 5c) for controlling the amount of the fuel supplied from the low-pressure pump (7, 7a, 7b, 7c) to the high-pressure pump (5, 5a, 5b, 5c), characterized in that at least one of the flow control valves (6a, 6b, 6c, 6d, 6e, 6f) is a normally open valve and at least one of the flow control valves (6a, 6b, 6c, 6d, 6e, 6f) is a normally closed valve. - at least one low-pressure pump (7, 7a, 7b, 7c) for raising the pressure of fuel to a first pressure level, - at least one high-pressure pump (5, 5a, 5b, 5c) for raising the pressure of the fuel from the first pressure level to a second pressure level that is higher than the first pressure level, - a fuel accumulator (4, 4a, 4b, 4c) that is connected to the high-pressure pump(s) (5, 5a, 5b, 5c) for receiving fuel at the second pressure level, - a fuel injector that is connected to the fuel accumulator (4, 4a, 4b, 4c) for receiving pressurized fuel from the fuel accumulator (4, 4a, 4b, 4c) and for injecting the fuel into a cylinder of the engine, and - at least two flow control valves (6a, 6b, 6c, 6d, 6e, 6f), each of the flow control valves (6a, 6b, 6c, 6d, 6e, 6f) being arranged between the at least one low-pressure pump (7, 7a, 7b, 7c) and the at least one high-pressure pump (5, 5a, 5b, 5c) for controlling the amount of the fuel supplied from the low-pressure pump (7, 7a, 7b, 7c) to the high-pressure pump (5, 5a, 5b, 5c),
Lock for a wing, in particular a sliding wing, with a lock case, which is closed on one side by a faceplate, and with a locking arrangement which is arranged in the lock case and has an opposed bolt combination with a hook-shaped first lock bolt and a hook-shaped second lock bolt which are arranged pivotably in relation to each other and are movable through an opening (5.1) in the faceplate between a retracted open position and a locking position which is extended out of the lock case and in which the lock bolts (12A, 12B) each engage in a recess (7.1) in a striker plate, wherein an actuating element, upon corresponding actuation, transfers the opposed lock bolts (12A, 12B) out of the retracted open position into the extended locking position or from the extended locking position into the retracted open position, and wherein a locking catch blocks the pivoting movement of the lock bolts (12A, 12B) in the extended locking position and releases said pivoting movement in the retracted open position, wherein the actuating element and the locking catch are combined in a slidably mounted blocking slider which is displaceable between a release position in the retracted open position and a blocking position in the extended locking position, wherein the blocking slider blocks the lock bolts (12A, 12B) in the blocking position, characterized in that the blocking slider in its blocking position protrudes out of the lock case and engages in the recess (7.1) in the striker plate, and in that the actuating element comprises an oblique guide slot and an actuating pin which is guided in the guide slot and can be acted upon by an actuating means.
Intraocular lens comprising an optical part and an adjoining haptic part, wherein the optical part comprises an optically imaging element and a telescope, the entire telescope has an integral embodiment and is integrated into the optically imaging element, wherein the telescope is a convex-concave telescope embodied as a single lens system, and a front side facing the incident light in the case of light incident on the intraocular lens has convex curvature and a rear side facing away from the incident light has concave curvature, characterized in that the telescope also has an integral embodiment with the optically imaging element.