An endoscopic clipping system for treating tissue, comprising: an applicator including a catheter and a control member extending therethrough, the catheter extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough, the control member longitudinally movable relative to the catheter and including an abutment structure proximate a distal end thereof; and a clip assembly releasably coupleable to a distal end of the applicator, the clip assembly including a pair of clip arms, each of the clip arms extending from a proximal end to a distal end, the proximal end of each of the clip arms slidably received within a channel of a capsule and configured to be releasably coupled to the distal end of the control member so that the clip arms are movable relative to the capsule between a tissue receiving configuration, in which distal ends of the clip arms are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another, the capsule including proximal tabs movable between a biased non-engaging configuration, in which the proximal tabs extend into the channel, and an engaging configuration, in which the proximal tabs extend laterally outward relative to a longitudinal axis of the capsule to engage an engaging portion of the lumen of the catheter, characterised in that the endoscopic clipping system is a reloadable endoscopic clipping system and in that the proximal tabs are configured to move from the non-engaging configuration to the engaging configuration when the abutment structure is moved into the capsule. an applicator including a catheter and a control member extending therethrough, the catheter extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough, the control member longitudinally movable relative to the catheter and including an abutment structure proximate a distal end thereof; and a clip assembly releasably coupleable to a distal end of the applicator, the clip assembly including a pair of clip arms, each of the clip arms extending from a proximal end to a distal end, the proximal end of each of the clip arms slidably received within a channel of a capsule and configured to be releasably coupled to the distal end of the control member so that the clip arms are movable relative to the capsule between a tissue receiving configuration, in which distal ends of the clip arms are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another, the capsule including proximal tabs movable between a biased non-engaging configuration, in which the proximal tabs extend into the channel, and an engaging configuration, in which the proximal tabs extend laterally outward relative to a longitudinal axis of the capsule to engage an engaging portion of the lumen of the catheter, characterised in that the endoscopic clipping system is a reloadable endoscopic clipping system and in that the proximal tabs are configured to move from the non-engaging configuration to the engaging configuration when the abutment structure is moved into the capsule.