A system for the iontophoretic transdermal delivery of a therapeutic agent to reduce nicotine cravings in a user from an inhaled form of tobacco use, the system comprising: a conformable patch for the iontophoretic transdermal delivery of the therapeutic agent (51, 51p), the patch having a tissue contacting side, a non tissue contacting side, a therapeutic agent reservoir and an electrode assembly (14, 20, 30, 510, 512) comprising at least a first electrode, the electrode assembly electrically coupled to the therapeutic agent reservoir (51, 51p); the patch configured to be electrically coupled to a current source; an inhalation sensing device positionable in the user's mouth, the inhalation sensing device mimicking an inhaled form of tobacco and configured to sense an inhalation characteristic by the user during tobacco inhalation and wirelessly signal an output corresponding to the inhalation characteristic; a controller (93, 290, 530) coupled to the patch for controlling the iontophoretic delivery of the therapeutic agent (51, 51p); the controller (93, 290, 530) configured to receive the output corresponding to the sensed inhalation characteristic and in response to the inhalation characteristic, deliver a dose of therapeutic agent (51, 51p) from the electrode assembly (14, 20, 30, 510, 512) into the skin during a first period using a first current having a polarity and voltage to repel the therapeutic agent (51, 51p) out of the electrode assembly (14, 20, 30, 510, 512) and a therapeutic agent delivery profile configured to mimic a nicotine delivery profile (350, 350a) for the inhaled form of tobacco use based on the sensed inhalation characteristic; and retain the therapeutic agent in the electrode assembly (14, 20, 30, 510, 512) during a second period using a second current having a polarity and voltage to retain the therapeutic agent (51, 51p) in the electrode assembly (14, 20, 30, 510, 512) such that delivery of the therapeutic agent (51, 51p) into the skin during the second period is minimized, wherein the first period comprises a delivery period and the second period comprises a non-delivery period which together comprise a delivery cycle period. a conformable patch for the iontophoretic transdermal delivery of the therapeutic agent (51, 51p), the patch having a tissue contacting side, a non tissue contacting side, a therapeutic agent reservoir and an electrode assembly (14, 20, 30, 510, 512) comprising at least a first electrode, the electrode assembly electrically coupled to the therapeutic agent reservoir (51, 51p); the patch configured to be electrically coupled to a current source; an inhalation sensing device positionable in the user's mouth, the inhalation sensing device mimicking an inhaled form of tobacco and configured to sense an inhalation characteristic by the user during tobacco inhalation and wirelessly signal an output corresponding to the inhalation characteristic; a controller (93, 290, 530) coupled to the patch for controlling the iontophoretic delivery of the therapeutic agent (51, 51p); the controller (93, 290, 530) configured to receive the output corresponding to the sensed inhalation characteristic and in response to the inhalation characteristic, deliver a dose of therapeutic agent (51, 51p) from the electrode assembly (14, 20, 30, 510, 512) into the skin during a first period using a first current having a polarity and voltage to repel the therapeutic agent (51, 51p) out of the electrode assembly (14, 20, 30, 510, 512) and a therapeutic agent delivery profile configured to mimic a nicotine delivery profile (350, 350a) for the inhaled form of tobacco use based on the sensed inhalation characteristic; and retain the therapeutic agent in the electrode assembly (14, 20, 30, 510, 512) during a second period using a second current having a polarity and voltage to retain the therapeutic agent (51, 51p) in the electrode assembly (14, 20, 30, 510, 512) such that delivery of the therapeutic agent (51, 51p) into the skin during the second period is minimized, wherein the first period comprises a delivery period and the second period comprises a non-delivery period which together comprise a delivery cycle period.