A compound of Formula or a stereoisomeric form thereof, wherein R 1 is phenyl or 2-pyridinyl, each optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -C 1-4 alkyl-OH, -CN, -C 1-4 alkyl-O-C 1-4 alkyl, C 3-7 cycloalkyl, -O-C 1-4 alkyl, monohalo-C 1-4 alkyloxy, polyhalo-C 1-4 alkyloxy, SF 5, C 1-4 alkylthio, monohalo-C 1-4 alkylthio and polyhalo-C 1-4 alkylthio; R 2 is selected from the group consisting of C 1-4 alkyl; C 3-7 cycloalkyl; Het 1; Aryl; Het 2; and C 1-4 alkyl substituted with one or more substituents each independently selected from the group consisting of halo, C 3-7 cycloalkyl, Aryl, Het 1 and Het 2; wherein Aryl is phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; Het 1 is selected from the group consisting of oxetanyl, tetrahydrofuranyl and tetrahydropyranyl; Het 2 is (a) a 6-membered aromatic heterocyclyl substituent selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, each of which may be optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; or (b) a 5-membered aromatic heterocyclyl selected from the group consisting of thiazolyl, oxazolyl, 1H -pyrazolyl and 1H -imidazolyl, each of which may be optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; R' and R" are each independently selected from the group consisting of hydrogen, C 1-4 alkyl and -C 2-4 alkyl-OH; R 3 is selected from hydrogen and C 1-4 alkyl; and R 4 is selected from the group consisting of hydrogen, C 1-4 alkyl, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -C 1-4 alkyl-O-C 1-4 alkyl and -C 1-4 alkyl-OH; or a N-oxide, or a pharmaceutically acceptable salt or a solvate thereof. R 1 is phenyl or 2-pyridinyl, each optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -C 1-4 alkyl-OH, -CN, -C 1-4 alkyl-O-C 1-4 alkyl, C 3-7 cycloalkyl, -O-C 1-4 alkyl, monohalo-C 1-4 alkyloxy, polyhalo-C 1-4 alkyloxy, SF 5, C 1-4 alkylthio, monohalo-C 1-4 alkylthio and polyhalo-C 1-4 alkylthio; R 2 is selected from the group consisting of C 1-4 alkyl; C 3-7 cycloalkyl; Het 1; Aryl; Het 2; and C 1-4 alkyl substituted with one or more substituents each independently selected from the group consisting of halo, C 3-7 cycloalkyl, Aryl, Het 1 and Het 2; wherein Aryl is phenyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; Het 1 is selected from the group consisting of oxetanyl, tetrahydrofuranyl and tetrahydropyranyl; Het 2 is (a) a 6-membered aromatic heterocyclyl substituent selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl, each of which may be optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; or (b) a 5-membered aromatic heterocyclyl selected from the group consisting of thiazolyl, oxazolyl, 1H -pyrazolyl and 1H -imidazolyl, each of which may be optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, -C 1-4 alkyl-OH, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -CN, -O-C 1-4 alkyl, -OH, -C 1-4 alkyl-O-C 1-4 alkyl, -NR'R", -NHC C 1-4 alkyl, -C NR'R", -C NH[C C 1-4 alkyl], -S 2 NR'R", -S 2 NH[C C 1-4 alkyl] and -SO 2 -C 1-4 alkyl; R' and R" are each independently selected from the group consisting of hydrogen, C 1-4 alkyl and -C 2-4 alkyl-OH; R 3 is selected from hydrogen and C 1-4 alkyl; and R 4 is selected from the group consisting of hydrogen, C 1-4 alkyl, monohalo-C 1-4 alkyl, polyhalo-C 1-4 alkyl, -C 1-4 alkyl-O-C 1-4 alkyl and -C 1-4 alkyl-OH;