An article of footwear comprising: an upper; and a sole structure secured to the upper and including a heel area and a forefoot area, the sole structure having a sealed chamber located in the forefoot area and formed from a polymer material enclosing a fluid, the sealed chamber comprising: a first subchamber (41a") located in a lateral portion of the sole structure having at least two first lobes extending outward toward a lateral side of the sole structure, the first subchamber having a first volume; a second subchamber (41b") located in a medial portion of the sole structure having at least two second lobes extending outward toward a medial side of the sole structure, the second subchamber having a second volume that is less than the first volume; and a third subchamber (41c") having a third volume that is less than the second volume, each of the first subchamber, the second subchamber, and the third subchamber having a first surface and an opposite second surface devoid of internal connections that secure interior portions of the first surface to interior portions of the second surface, and a pressure of the fluid being substantially equal to an ambient pressure of air surrounding the chamber, wherein the second subchamber is in fluid communication with the first subchamber via a conduit (44a") that limits fluid flow between the first subchamber and the second subchamber by means of a valve and the second subchamber is in fluid communication with the third subchamber via a conduit (44b") that limits fluid flow between the second subchamber and third subchamber by means of a valve. an upper; and a sole structure secured to the upper and including a heel area and a forefoot area, the sole structure having a sealed chamber located in the forefoot area and formed from a polymer material enclosing a fluid, the sealed chamber comprising: a first subchamber (41a") located in a lateral portion of the sole structure having at least two first lobes extending outward toward a lateral side of the sole structure, the first subchamber having a first volume; a second subchamber (41b") located in a medial portion of the sole structure having at least two second lobes extending outward toward a medial side of the sole structure, the second subchamber having a second volume that is less than the first volume; and a third subchamber (41c") having a third volume that is less than the second volume, each of the first subchamber, the second subchamber, and the third subchamber having a first surface and an opposite second surface devoid of internal connections that secure interior portions of the first surface to interior portions of the second surface, and a pressure of the fluid being substantially equal to an ambient pressure of air surrounding the chamber, wherein the second subchamber is in fluid communication with the first subchamber via a conduit (44a") that limits fluid flow between the first subchamber and the second subchamber by means of a valve and the second subchamber is in fluid communication with the third subchamber via a conduit (44b") that limits fluid flow between the second subchamber and third subchamber by means of a valve. a first subchamber (41a") located in a lateral portion of the sole structure having at least two first lobes extending outward toward a lateral side of the sole structure, the first subchamber having a first volume; a second subchamber (41b") located in a medial portion of the sole structure having at least two second lobes extending outward toward a medial side of the sole structure, the second subchamber having a second volume that is less than the first volume; and a third subchamber (41c") having a third volume that is less than the second volume, each of the first subchamber, the second subchamber, and the third subchamber having a first surface and an opposite second surface devoid of internal connections that secure interior portions of the first surface to interior portions of the second surface, and a pressure of the fluid being substantially equal to an ambient pressure of air surrounding the chamber, wherein the second subchamber is in fluid communication with the first subchamber via a conduit (44a") that limits fluid flow between the first subchamber and the second subchamber by means of a valve and the second subchamber is in fluid communication with the third subchamber via a conduit (44b") that limits fluid flow between the second subchamber and third subchamber by means of a valve.