A system for treating benign prostatic hypertrophy, comprising: an anchor assembly; and a delivery device housing the anchor assembly, the delivery device including: (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip, the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip; and wherein either: (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments, thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source, alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element, the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element. an anchor assembly; and a delivery device housing the anchor assembly, the delivery device including: (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip, the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip; and wherein either: (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments, thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source, alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element, the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element. (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip, the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip; and (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments, thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source, alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element, the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element.