mhurhangee/ep-ind-claims huggingface dataset:
A method of quantifying chimeric cfDNA in a sample from a patient, the method comprising: (a) providing a cell-free DNA (cfDNA) sample from a blood, serum or plasma sample obtained from a patient; (b) performing a multiplex digital PCR comprising at least a first amplification and a second amplification, wherein the first amplification targets a first single copy genomic locus and results in production of a first amplicon and a second amplification targets a second single copy genomic locus and results in production of a second amplicon, wherein the first and second amplicon differ in length by at least 50 base pairs; (c) determining the proportion of the first or second amplicon in the total amplified product from the digital PCR of step (b) to provide a correction factor for the amplifiable fraction of the cfDNA sample, and (d) correcting a diagnostic digital PCR performed on the cfDNA sample to evaluate the level of chimeric DNA present in the sample using the correction factor determined in step (c). (a) providing a cell-free DNA (cfDNA) sample from a blood, serum or plasma sample obtained from a patient; (b) performing a multiplex digital PCR comprising at least a first amplification and a second amplification, wherein the first amplification targets a first single copy genomic locus and results in production of a first amplicon and a second amplification targets a second single copy genomic locus and results in production of a second amplicon, wherein the first and second amplicon differ in length by at least 50 base pairs; (c) determining the proportion of the first or second amplicon in the total amplified product from the digital PCR of step (b) to provide a correction factor for the amplifiable fraction of the cfDNA sample, and (d) correcting a diagnostic digital PCR performed on the cfDNA sample to evaluate the level of chimeric DNA present in the sample using the correction factor determined in step (c).
A packaging member (10; 10') for a hernia repair device including a surgical mesh and at least one grasping member (140a, 140b), the packaging member comprising: a central portion configured to receive the surgical mesh; at least one recessed track section configured to receive the at least one grasping member; and a knob (63, 65) extending into the at least one recessed track section, the knob configured to retain the at least one grasping member within the at least one recessed track section, characterized in that, the hernia repair device defining a folding axis (F-F), the packaging member further includes a pair of indicia indicating a location of the folding axis. a central portion configured to receive the surgical mesh; at least one recessed track section configured to receive the at least one grasping member; and a knob (63, 65) extending into the at least one recessed track section, the knob configured to retain the at least one grasping member within the at least one recessed track section,
A printer-implemented method for printing a forensic-encoded 2D barcode, comprising: storing, in a storage module of a printer, one or more fonts including glyphs that can be printed within or adjacent to an area of the forensic-encoded 2D barcode; receiving, from a computer, instructions to print the forensic-encoded 2D barcode including one or more glyphs of the glyphs included in the one or more fonts, said instructions not including the one or more glyphs to be printed; accessing, from the storage module of the printer and using a processor, the one or more fonts including the glyphs; selecting, using a processor and based on said instructions, the one or more glyphs from the glyphs included in the one or more fonts to be added to the forensic-encoded 2D barcode; generating, from said instructions and using a processor, the forensic-encoded 2D barcode including the one or more selected glyphs; and printing the forensic-encoded 2D barcode. storing, in a storage module of a printer, one or more fonts including glyphs that can be printed within or adjacent to an area of the forensic-encoded 2D barcode; receiving, from a computer, instructions to print the forensic-encoded 2D barcode including one or more glyphs of the glyphs included in the one or more fonts, said instructions not including the one or more glyphs to be printed; accessing, from the storage module of the printer and using a processor, the one or more fonts including the glyphs; selecting, using a processor and based on said instructions, the one or more glyphs from the glyphs included in the one or more fonts to be added to the forensic-encoded 2D barcode; generating, from said instructions and using a processor, the forensic-encoded 2D barcode including the one or more selected glyphs; and printing the forensic-encoded 2D barcode.
System for counting corrugations in a flexible material, the system is provided with a carrier with a surface for positioning the flexible material, a light source for illuminating the flexible material on the carrier, receiving means for receiving light originating from the flexible material, counting means for determining the number of corrugations in the flexible material based on data from the receiving means, wherein the carrier is provided with a measuring area and with aligning means for aligning the flexible material in the measuring area, characterized in that the receiving means comprise a camera for making one or more image recordings of the measuring area and in that the counting means comprise a processor, which is arranged for counting the number of corrugations in one or more of the image recordings, wherein the system is further provided with means for displaying the number of counted corrugations in the flexible material in the measuring area.
A method of making an equipment cover (200, 400, 45, 55), the method comprising: moulding a cover (210, 410) from a substantially transparent or translucent polymer to form a cover having a textured outer surface (220, 420) and a generally smoother inner surface (230, 430); applying a coating (240, 440) having reflective components to the inner surface (230, 430), wherein the coating (240, 440) having reflective components comprises reflective components dispersed within a substantially transparent or translucent coating, and wherein the reflective components comprise at least one of: metallic components; and mica powder, flakes or scrap; and after applying the coating having reflective components to the inner surface (230, 430), applying a further coating (250, 450) to the inner surface, wherein the further coating is substantially opaque. moulding a cover (210, 410) from a substantially transparent or translucent polymer to form a cover having a textured outer surface (220, 420) and a generally smoother inner surface (230, 430); applying a coating (240, 440) having reflective components to the inner surface (230, 430), wherein the coating (240, 440) having reflective components comprises reflective components dispersed within a substantially transparent or translucent coating, and wherein the reflective components comprise at least one of: metallic components; and mica powder, flakes or scrap; and metallic components; and mica powder, flakes or scrap; and after applying the coating having reflective components to the inner surface (230, 430), applying a further coating (250, 450) to the inner surface, wherein the further coating is substantially opaque.
An image forming apparatus comprising: an image forming unit which forms an image on a paper in an image forming position, wherein the unit is configured to form an image on both sides of the paper; a transportation path which transports the paper to the image forming position; an acquisition unit arranged in upstream side of the image forming position in a paper transportation direction, and which acquires a shift amount from an edge reference position to an edge of the paper in a paper width direction perpendicular to the paper transportation direction; a pair of transport rollers arranged in the upstream side of the acquisition unit in the paper transportation direction, and being capable of swinging in the paper width direction; and a control unit configured to determine an instruction value based on a state of the paper and the shift amount before the pair of transport rollers moves, and to move the pair of transport rollers in accordance with the instruction value in the paper width direction, wherein the instruction value is used to control the movement of paper by the transport rollers to align an image to be formed on the paper, and wherein the state of the paper is the frictional force of the paper between the paper and the transportation path, and wherein the control unit is configured to determine the instruction value according to whether image formation is carried out only on a first side of the paper P in one side printing or image formation is carried out on a second side, which is a back side of the first side of the paper P, in cases of both-side printing. an image forming unit which forms an image on a paper in an image forming position, wherein the unit is configured to form an image on both sides of the paper; a transportation path which transports the paper to the image forming position; an acquisition unit arranged in upstream side of the image forming position in a paper transportation direction, and which acquires a shift amount from an edge reference position to an edge of the paper in a paper width direction perpendicular to the paper transportation direction; a pair of transport rollers arranged in the upstream side of the acquisition unit in the paper transportation direction, and being capable of swinging in the paper width direction; and a control unit configured to determine an instruction value based on a state of the paper and the shift amount before the pair of transport rollers moves, and to move the pair of transport rollers in accordance with the instruction value in the paper width direction, wherein the instruction value is used to control the movement of paper by the transport rollers to align an image to be formed on the paper, and wherein the state of the paper is the frictional force of the paper between the paper and the transportation path, and
Evaluation method for a number of X-ray images of a human examination object acquired by means of X-ray equipment, - wherein the X-ray images are each spatially resolved in exactly two dimensions and include the arms (6a, 6b) of the examination object, - wherein, based on the examination object, in each case one dimension extends in the head-foot direction and a further dimension extends from left to right, - wherein in each case the respective body region is detected in the X-ray images in steps that are equidistant in the head-foot direction and, based on this, the water-equivalent diameter of the examination object is determined in a plane orthogonal to the head-foot direction, - wherein the water-equivalent diameters determined for the respective position (z) are stored with allocation to the X-ray images and the respective position (z) in the head-foot direction, characterised in that the arms (6a, 6b) of the examination object are removed from the X-ray image before determination of the water-equivalent diameters. - wherein the X-ray images are each spatially resolved in exactly two dimensions and include the arms (6a, 6b) of the examination object, - wherein, based on the examination object, in each case one dimension extends in the head-foot direction and a further dimension extends from left to right, - wherein in each case the respective body region is detected in the X-ray images in steps that are equidistant in the head-foot direction and, based on this, the water-equivalent diameter of the examination object is determined in a plane orthogonal to the head-foot direction, - wherein the water-equivalent diameters determined for the respective position (z) are stored with allocation to the X-ray images and the respective position (z) in the head-foot direction, characterised in that the arms (6a, 6b) of the examination object are removed from the X-ray image before determination of the water-equivalent diameters.
A fusion antibody for use in the treatment of an arylsulfatase A deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion antibody having arylsulfatase A activity, wherein the fusion antibody comprises: (a) a fusion protein comprising the amino acid sequences of an immunoglobulin heavy chain and an arylsulfatase A, wherein the immunoglobulin heavy chain comprises a CDR1 corresponding to the amino acid sequence of SEQ ID NO:1, a CDR2 corresponding to the amino acid sequence of SEQ ID NO:2, or a CDR3 corresponding to the amino acid sequence of SEQ ID NO:3; and (b) an immunoglobulin light chain, wherein the immunoglobulin light chain is an immunoglobulin light chain of kappa or lambda class and comprises a CDR1 corresponding to the amino acid sequence of SEQ ID NO:4, a CDR2 corresponding to the amino acid sequence of SEQ ID NO:5, or a CDR3 corresponding to the amino acid sequence of SEQ ID NO:6; wherein the fusion antibody crosses the blood brain barrier and the ASA retains at least 20% of its activity, on a molar basis, compared to its activity as a separate entity. (a) a fusion protein comprising the amino acid sequences of an immunoglobulin heavy chain and an arylsulfatase A, wherein the immunoglobulin heavy chain comprises a CDR1 corresponding to the amino acid sequence of SEQ ID NO:1, a CDR2 corresponding to the amino acid sequence of SEQ ID NO:2, or a CDR3 corresponding to the amino acid sequence of SEQ ID NO:3; and (b) an immunoglobulin light chain, wherein the immunoglobulin light chain is an immunoglobulin light chain of kappa or lambda class and comprises a CDR1 corresponding to the amino acid sequence of SEQ ID NO:4, a CDR2 corresponding to the amino acid sequence of SEQ ID NO:5, or a CDR3 corresponding to the amino acid sequence of SEQ ID NO:6;
A wind turbine blade pitch system for rotating rotor blades of a wind turbine relative to a hub, the wind turbine pitch system comprising: an actuating stem moveable in an axial direction; a traverse holder; a traverse rotatably mounted on the actuating stem, wherein the traverse comprises a traverse arm radially extending from the traverse holder; a connection plate rotationally coupling the traverse and the traverse holder; and, a crank arm connected at one end to the traverse arm and at another end to a rotatable pitch bearing coupled to the rotor blade, the crank arm being configured to convert the axial movement of the actuating stem into a rotational movement of the rotor blade, characterized in that the connection plate comprises: an inner annular flange region secured to the traverse holder; an outer annular flange region secured to the traverse; and, a central annular region radially positioned between and connecting the inner and outer annular flange regions (78, 76), wherein the central annular region is configured to flex relative to the inner and outer annular flange portions (78, 76) to reduce the stiffness of the connection plate between inner and outer annular flange portions (78, 76). an actuating stem moveable in an axial direction; a traverse holder; a traverse rotatably mounted on the actuating stem, wherein the traverse comprises a traverse arm radially extending from the traverse holder; a connection plate rotationally coupling the traverse and the traverse holder; and, a crank arm connected at one end to the traverse arm and at another end to a rotatable pitch bearing coupled to the rotor blade, the crank arm being configured to convert the axial movement of the actuating stem into a rotational movement of the rotor blade, characterized in that the connection plate comprises: an inner annular flange region secured to the traverse holder; an outer annular flange region secured to the traverse; and, a central annular region radially positioned between and connecting the inner and outer annular flange regions (78, 76), wherein the central annular region is configured to flex relative to the inner and outer annular flange portions (78, 76) to reduce the stiffness of the connection plate between inner and outer annular flange portions (78, 76). an inner annular flange region secured to the traverse holder; an outer annular flange region secured to the traverse; and, a central annular region radially positioned between and connecting the inner and outer annular flange regions (78, 76), wherein the central annular region is configured to flex relative to the inner and outer annular flange portions (78, 76) to reduce the stiffness of the connection plate between inner and outer annular flange portions (78, 76).
Compound according to the structure: where R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, R 11 are selected from: -H, -(C 1 -C 12)-alkyl, -O-(C 1 -C 12) -alkyl, -(C 6 -C 20)-aryl, -O-(C 6 -C 20)-aryl, -NO 2, NH 2, -N[((C 1 -C 12) -alkyl)] 2.
A covering system (100; 1002) for covering an architectural opening, comprising: a movable covering (112; 1016); a first shaft (118; 1022) operatively connected to said covering; a second shaft operatively connected to said covering; a housing (128, 130; 128', 130'; 128", 130"; 128*; 130*); and a spring (124, 126; 124', 126S,L; 124", 126", 124**, 126*) within said housing; with said first shaft operatively engaging said spring, and said second shaft not operatively engaging said spring, characterized in that said first and second shafts extend completely through said housing. a movable covering (112; 1016); a first shaft (118; 1022) operatively connected to said covering; a second shaft operatively connected to said covering; a housing (128, 130; 128', 130'; 128", 130"; 128*; 130*); and a spring (124, 126; 124', 126S,L; 124", 126", 124**, 126*) within said housing; with said first shaft operatively engaging said spring, and said second shaft not operatively engaging said spring,
A method for processing a control channel at a user agent to identify at least one of an uplink and a downlink resource allocated by a resource grant within a multi-carrier communication system wherein resource grants are specified by control channel element subsets, wherein each control channel element subset is a control channel candidate, the method comprising the steps of: associating a first subset of control channel candidates on a first carrier with the first carrier, wherein the first subset associated with the first carrier includes first carrier candidates; associating a second subset of control channel candidates on a first carrier with a second carrier, wherein the second subset associated with the second carrier includes second carrier candidates; receiving a control channel candidate on the first carrier; and attempting to decode the received control channel candidate to identify a resource grant for the second carrier, wherein there are first, second, fourth and eighth aggregation levels of control channel candidates, and wherein control channel elements of a second control channel candidate corresponding to the second carrier at each aggregation level are shifted from control channel elements of a first control channel candidate corresponding to the first carrier at each aggregation level by a number of control channel elements. associating a first subset of control channel candidates on a first carrier with the first carrier, wherein the first subset associated with the first carrier includes first carrier candidates; associating a second subset of control channel candidates on a first carrier with a second carrier, wherein the second subset associated with the second carrier includes second carrier candidates; receiving a control channel candidate on the first carrier; and attempting to decode the received control channel candidate to identify a resource grant for the second carrier, wherein there are first, second, fourth and eighth aggregation levels of control channel candidates, and wherein control channel elements of a second control channel candidate corresponding to the second carrier at each aggregation level are shifted from control channel elements of a first control channel candidate corresponding to the first carrier at each aggregation level by a number of control channel elements.
A pharmaceutical formulation comprising an active ingredient in an amount of 0.01 w/v% to 5 w/v%, wherein the active ingredient is a compound of general formula, or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are each independently selected from a C 1-4 alkyl or a C 3-6 cycloalkyl; and n is 1 or 2; wherein, a) the pharmaceutical formulation is a fat emulsion and further comprises an oily component in an amount of 5 w/v% to 30 w/v%, an emulsifying agent in an amount of 0.5 w/v% to 5 w/v%, and an co-emulsifying agent in an amount of 0 to 0.2 w/v%; or b) the pharmaceutical formulation is an aqueous solution and further comprises: a solubilizing agent, in an amount of 0.1 w/v% to 20 w/v%; and a co-solvent, in an amount of 0 w/v% to 30 w/v%; preferably, R 1 is selected from methyl, ethyl or isopropyl; and R 2 is selected from methyl, ethyl, isopropyl or cyclopropyl; more preferably, the compound of general formula is selected from further preferably, the compound of general formula is selected from wherein R 1 and R 2 are each independently selected from a C 1-4 alkyl or a C 3-6 cycloalkyl; and n is 1 or 2; wherein, a) the pharmaceutical formulation is a fat emulsion and further comprises an oily component in an amount of 5 w/v% to 30 w/v%, an emulsifying agent in an amount of 0.5 w/v% to 5 w/v%, and an co-emulsifying agent in an amount of 0 to 0.2 w/v%; or b) the pharmaceutical formulation is an aqueous solution and further comprises: a solubilizing agent, in an amount of 0.1 w/v% to 20 w/v%; and a co-solvent, in an amount of 0 w/v% to 30 w/v%; a) the pharmaceutical formulation is a fat emulsion and further comprises an oily component in an amount of 5 w/v% to 30 w/v%, an emulsifying agent in an amount of 0.5 w/v% to 5 w/v%, and an co-emulsifying agent in an amount of 0 to 0.2 w/v%; or an oily component in an amount of 5 w/v% to 30 w/v%, an emulsifying agent in an amount of 0.5 w/v% to 5 w/v%, and an co-emulsifying agent in an amount of 0 to 0.2 w/v%; or b) the pharmaceutical formulation is an aqueous solution and further comprises: a solubilizing agent, in an amount of 0.1 w/v% to 20 w/v%; and a co-solvent, in an amount of 0 w/v% to 30 w/v%; preferably, R 1 is selected from methyl, ethyl or isopropyl; and R 2 is selected from methyl, ethyl, isopropyl or cyclopropyl; more preferably, the compound of general formula is selected from further preferably, the compound of general formula is selected from