Filling device for metered filling of liquid or fine powdery filling material from a filling material storage container into filling material dose receiving containers provided in a contamination-protected manner in a single-use isolator, comprising - the single-use isolator having the filling material dose receiving containers provided therein, - means for holding the filling material storage container with content outside the single-use isolator, - a controllable filling material removal device for removal, by dose, of filling material from the filling material storage container outside of the single-use isolator, - a filling material dispensing device within the single-use isolator for dispensing, by dose, filling material to relevant filling material dose receiving containers in the single-use isolator, - a line arrangement which interconnects the filling material storage container and the filling material dispensing device and is intended for conducting filling material removed from the filling material storage container, by the filling material removal device, to the filling material dispensing device, characterised in that the filling device further comprises - at least one ultrasound flowmeter, of the clamp-on type, which is provided outside of the single-use isolator, on the line arrangement, and which is fixed on the outside of the line arrangement in a manner surrounding it at least in regions, for acquiring the respective flow amount, - a controller for measuring the respective filling material dose to be removed from the filling material storage container, on the basis of information of the flow meter relating to the flow amount, and for controlling the filling material removal device. comprising - the single-use isolator having the filling material dose receiving containers provided therein, - means for holding the filling material storage container with content outside the single-use isolator, - a controllable filling material removal device for removal, by dose, of filling material from the filling material storage container outside of the single-use isolator, - a filling material dispensing device within the single-use isolator for dispensing, by dose, filling material to relevant filling material dose receiving containers in the single-use isolator, - a line arrangement which interconnects the filling material storage container and the filling material dispensing device and is intended for conducting filling material removed from the filling material storage container, by the filling material removal device, to the filling material dispensing device, - the single-use isolator having the filling material dose receiving containers provided therein, - means for holding the filling material storage container with content outside the single-use isolator, - a controllable filling material removal device for removal, by dose, of filling material from the filling material storage container outside of the single-use isolator, - a filling material dispensing device within the single-use isolator for dispensing, by dose, filling material to relevant filling material dose receiving containers in the single-use isolator, - a line arrangement which interconnects the filling material storage container and the filling material dispensing device and is intended for conducting filling material removed from the filling material storage container, by the filling material removal device, to the filling material dispensing device, characterised in that the filling device further comprises - at least one ultrasound flowmeter, of the clamp-on type, which is provided outside of the single-use isolator, on the line arrangement, and which is fixed on the outside of the line arrangement in a manner surrounding it at least in regions, for acquiring the respective flow amount, - a controller for measuring the respective filling material dose to be removed from the filling material storage container, on the basis of information of the flow meter relating to the flow amount, and for controlling the filling material removal device. - at least one ultrasound flowmeter, of the clamp-on type, which is provided outside of the single-use isolator, on the line arrangement, and which is fixed on the outside of the line arrangement in a manner surrounding it at least in regions, for acquiring the respective flow amount, - a controller for measuring the respective filling material dose to be removed from the filling material storage container, on the basis of information of the flow meter relating to the flow amount, and for controlling the filling material removal device.