A compound represented by Formula I: wherein X is NH or S; R 1 is selected from the group consisting of C (CR 5 R 6) d N(R 4) 2, C N=S R 5 R 6, (CR 5 R 6) d C (CR 5 R 6) d R 4, (CR 5 R 6) d C (CR 5 R 6) d OR 4, and (CR 5 R 6) d C (CR 5 R 6) d N(R 4) 2, wherein each R 4 is independently selected from the group consisting of hydrogen, hydroxyl, C 1 -C 8 alkyl, C 1 -C 8 hydroxyalkyl, (CR 5 R 6) d and N(R 4) 2 may form a 3-7 membered heterocyclic ring, comprising of aziridine, azetidine, pyrrolidine, 5-fluoropyrrolidine, piperidine, 6-fluoropiperidine, N-methylpiperazine, morpholine, 2,6-dimethylmorpholine, thiomorpholine, and wherein said heterocyclic ring may be optionally substituted with up to three of R 5; wherein R 5 and R 6 are independently selected from the group consisting of hydrogen, halo, hydroxyl, C 1 -C 8 alkyl, C 1 -C 8 hydroxyalkyl, C 1 -C 8 alkoxyalkyl, alkoxycarbonylalkyl, and alkoxycarbonyl; a is 0 or an integer of from 1 to 3; d is 0; b is 0; Y is selected from the group consisting of: -(CH 2) g -O-(CH 2) h -; -(CH 2) g -NR 1 -(CH 2) h -; -(CH 2) g -S n -(CH 2) h -; and a single bond; wherein g is 0; h is 0; n is 0; R 1 is independently selected from the group consisting of hydrogen, CF 3, alkyl, and hydroxyalkyl; Ring A is (i) Phenyl; R III represents optionally 1-3 substituents independently selected from the group consisting of C 1 -C 5 linear or branched alkyl, halogen, cyano, and nitro; Z is selected from the group consisting of (CH 2) i N(R 7)C N(R 8)(CH 2) j (CH 2) i N(R 7)C; and C N(R 8)(CH 2) j; wherein: i is 0; j is 0; R 7 and R 8 are independently selected from the group consisting of hydrogen and alkyl; Ring B is which is selected from the group consisting of: wherein n is 0; R IV represents optionally 1-3 substituents, independently selected from the group consisting of alkoxy, alkyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, and nitro; and including any pharmaceutically acceptable salt. X is NH or S; R 1 is selected from the group consisting of C (CR 5 R 6) d N(R 4) 2, C N=S R 5 R 6, (CR 5 R 6) d C (CR 5 R 6) d R 4, (CR 5 R 6) d C (CR 5 R 6) d OR 4, and (CR 5 R 6) d C (CR 5 R 6) d N(R 4) 2, wherein each R 4 is independently selected from the group consisting of hydrogen, hydroxyl, C 1 -C 8 alkyl, C 1 -C 8 hydroxyalkyl, (CR 5 R 6) d and N(R 4) 2 may form a 3-7 membered heterocyclic ring, comprising of aziridine, azetidine, pyrrolidine, 5-fluoropyrrolidine, piperidine, 6-fluoropiperidine, N-methylpiperazine, morpholine, 2,6-dimethylmorpholine, thiomorpholine, and wherein said heterocyclic ring may be optionally substituted with up to three of R 5; wherein R 5 and R 6 are independently selected from the group consisting of hydrogen, halo, hydroxyl, C 1 -C 8 alkyl, C 1 -C 8 hydroxyalkyl, C 1 -C 8 alkoxyalkyl, alkoxycarbonylalkyl, and alkoxycarbonyl; a is 0 or an integer of from 1 to 3; d is 0; b is 0; Y is selected from the group consisting of: -(CH 2) g -O-(CH 2) h -; -(CH 2) g -NR 1 -(CH 2) h -; -(CH 2) g -S n -(CH 2) h -; and a single bond; -(CH 2) g -O-(CH 2) h -; -(CH 2) g -NR 1 -(CH 2) h -; -(CH 2) g -S n -(CH 2) h -; and a single bond; g is 0; h is 0; n is 0; R 1 is independently selected from the group consisting of hydrogen, CF 3, alkyl, and hydroxyalkyl; (i) Phenyl; R III represents optionally 1-3 substituents independently selected from the group consisting of C 1 -C 5 linear or branched alkyl, halogen, cyano, and nitro; Z is selected from the group consisting of (CH 2) i N(R 7)C N(R 8)(CH 2) j (CH 2) i N(R 7)C; and C N(R 8)(CH 2) j; wherein: i is 0; j is 0; R 7 and R 8 are independently selected from the group consisting of hydrogen and alkyl; Ring B is which is selected from the group consisting of: wherein n is 0; R IV represents optionally 1-3 substituents, independently selected from the group consisting of alkoxy, alkyl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, hydroxyalkyl, and nitro; and including any pharmaceutically acceptable salt. (CH 2) i N(R 7)C N(R 8)(CH 2) j (CH 2) i N(R 7)C; and C N(R 8)(CH 2) j; i is 0; j is 0; R 7 and R 8 are independently selected from the group consisting of hydrogen and alkyl;