A compound selected from the group consisting of a thieno[3,2-d]pyrimidine derivative of formula, and a pharmaceutically acceptable salt, hydrate and solvate thereof: wherein, Y is -CH=CR 1 -, -CC-, or -C(=O)NR 1 -; L is -C(=O)NR 2 -, -NR 2 C(=O)-, or -NR 2 C(=O)NR 2 -; R 1 and R 2 are each independently H, C 1-6 alkyl, or C 3-8 cycloalkyl; R is H, halogen, methyl, or methoxy; E is aryl of up to 14 C atoms, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO 2, -CN, -NH 2, -OH, -CF 3, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 3-8 cycloalkyl, -(CH 2) n -C 1-6 alkylamino, -(CH 2) n -diC 1-6 alkylamino, -(CH 2) n C 1-6 alkoxy, -(CH 2) n -OS(=O) 2 -C 1-6 alkyl, -(CH 2) n -Q, where Q is aryl of up to 14 C atoms and -(CH 2) n -C 2-13 heterocycloalkyl, wherein n is an integer number of 0 to 3, and the aryl and heterocycloalkyl are each independently unsubstituted or substituted by a substituent selected from the group consisting of C 1-6 alkyl, hydroxy-C 1-6 alkyl, halogen, diC 1-6 alkylamino, and C 1-6 alkoxy; or E is phenyl, pyridinyl, quinolinyl, isoquinolinyl, indolyl, isoxazlyl, or pyrazolyl, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO 2, -CN, -NH 2, -OH, -CF 3, C 1-6 alkyl, C 3-8 cycloalkyl, -(CH 2) n -C 1-6 alkylamino, -(CH 2) n -diC 1-6 alkylamino, -(CH 2) n C 1-6 alkoxy, -(CH 2) n -OS(=O) 2 -C 1-6 alkyl, -(CH 2) n -Q, where Q is aryl of up to 14 C atoms and -(CH 2) n -C 2-13 heterocycloalkyl, wherein n is an integer number of 0 to 3; and Z is H, -C(=O)R 3, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 3-8 cycloalkyl, C 2-7 heterocycloalkyl, aryl of up to 14 C atoms, wherein the aryl and heterocycloalkyl are each independently unsubstituted or substituted by C 1 - 6 alkyl, C 1-6 alkoxy, C 3-8 cycloalkyl, R 3 -C 2-7 heterocycloalkyl or C 2-7 heterocycloalkyl, and R 3 is C 1-6 alkyl, C 3-6 cycloalkyl, or phenyl. Y is -CH=CR 1 -, -CC-, or -C(=O)NR 1 -; L is -C(=O)NR 2 -, -NR 2 C(=O)-, or -NR 2 C(=O)NR 2 -; R 1 and R 2 are each independently H, C 1-6 alkyl, or C 3-8 cycloalkyl; R is H, halogen, methyl, or methoxy; E is aryl of up to 14 C atoms, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO 2, -CN, -NH 2, -OH, -CF 3, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 3-8 cycloalkyl, -(CH 2) n -C 1-6 alkylamino, -(CH 2) n -diC 1-6 alkylamino, -(CH 2) n C 1-6 alkoxy, -(CH 2) n -OS(=O) 2 -C 1-6 alkyl, -(CH 2) n -Q, where Q is aryl of up to 14 C atoms and -(CH 2) n -C 2-13 heterocycloalkyl, wherein n is an integer number of 0 to 3, and the aryl and heterocycloalkyl are each independently unsubstituted or substituted by a substituent selected from the group consisting of C 1-6 alkyl, hydroxy-C 1-6 alkyl, halogen, diC 1-6 alkylamino, and C 1-6 alkoxy; or E is phenyl, pyridinyl, quinolinyl, isoquinolinyl, indolyl, isoxazlyl, or pyrazolyl, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO 2, -CN, -NH 2, -OH, -CF 3, C 1-6 alkyl, C 3-8 cycloalkyl, -(CH 2) n -C 1-6 alkylamino, -(CH 2) n -diC 1-6 alkylamino, -(CH 2) n C 1-6 alkoxy, -(CH 2) n -OS(=O) 2 -C 1-6 alkyl, -(CH 2) n -Q, where Q is aryl of up to 14 C atoms and -(CH 2) n -C 2-13 heterocycloalkyl, wherein n is an integer number of 0 to 3; and Z is H, -C(=O)R 3, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 3-8 cycloalkyl, C 2-7 heterocycloalkyl, aryl of up to 14 C atoms, wherein the aryl and heterocycloalkyl are each independently unsubstituted or substituted by C 1 - 6 alkyl, C 1-6 alkoxy, C 3-8 cycloalkyl, R 3 -C 2-7 heterocycloalkyl or C 2-7 heterocycloalkyl, and R 3 is C 1-6 alkyl, C 3-6 cycloalkyl, or phenyl.