A bone plating system for fixation of fractures of bones including the humerus, femur, tibia or radius comprising: a bone plate; a drill block removably attachable to the bone plate; a first locking element (300, 330, 340) configured to be removably attached to the drill block and the bone plate by extending through a non-threaded drill block hole of the drill block and into an aligned receiving hole of the bone plate, the non-threaded drill block hole extending along a first axis, the first locking element (300,330,340) including a threaded surface configured to engage a threaded surface of the aligned receiving hole; and a second locking element formed as part of the drill block and configured to extend along a second axis from the drill block and into an opening in the bone plate in order to constrain movement of the bone plate and the drill block with respect to each other when the first locking element (300, 330, 340) is attached to the drill block and the bone plate; wherein the first and second axes are not parallel, thereby preventing removal of the drill block from the bone plate unless the first locking element (300, 320, 340) is removed from the aligned receiving hole of the bone plate, wherein the opening in the bone plate comprises an indentation in a side surface of the bone plate, characterised in that, the second locking element has a rectangular-shaped or square-shaped cross-section and the indentation is correspondingly-shaped, wherein the rectangular-shaped or square-shaped cross-section of the second locking element is adapted to fit in the indentation, and wherein the corresponding rectangular or square shapes of the second locking element and the indentation allow at least two flat portions or sides of the rectangles or squares to contact each other and constrain movement of the drill block relative to the bone plate. a bone plate; a drill block removably attachable to the bone plate; a first locking element (300, 330, 340) configured to be removably attached to the drill block and the bone plate by extending through a non-threaded drill block hole of the drill block and into an aligned receiving hole of the bone plate, the non-threaded drill block hole extending along a first axis, the first locking element (300,330,340) including a threaded surface configured to engage a threaded surface of the aligned receiving hole; and a second locking element formed as part of the drill block and configured to extend along a second axis from the drill block and into an opening in the bone plate in order to constrain movement of the bone plate and the drill block with respect to each other when the first locking element (300, 330, 340) is attached to the drill block and the bone plate; wherein the first and second axes are not parallel, thereby preventing removal of the drill block from the bone plate unless the first locking element (300, 320, 340) is removed from the aligned receiving hole of the bone plate, wherein the opening in the bone plate comprises an indentation in a side surface of the bone plate, characterised in that, the second locking element has a rectangular-shaped or square-shaped cross-section and the indentation is correspondingly-shaped, wherein the rectangular-shaped or square-shaped cross-section of the second locking element is adapted to fit in the indentation, and wherein the corresponding rectangular or square shapes of the second locking element and the indentation allow at least two flat portions or sides of the rectangles or squares to contact each other and constrain movement of the drill block relative to the bone plate.