mhurhangee/ep-ind-claims huggingface dataset:
A construct which, when expressed in a host cell, is capable of producing empty picornaviral capsids, the construct comprising: (i) a nucleotide sequence encoding a P1 capsid precursor protein; (ii) a nucleotide sequence encoding a 3C protease, capable of cleaving the picornavirus capsid precursor protein, wherein the protease includes a mutation at Cys142 which reduces its capsid precursor protein cleaving activity; and (iii) a control element which controls the expression of the protease such that, when the construct is present in the host cell, the control element causes the protease to be expressed at a level sufficient to cleave the capsid precursor protein, but not sufficient to induce significant toxicity in the host cell, wherein the control element is a retrovirus frameshift site. (i) a nucleotide sequence encoding a P1 capsid precursor protein; (ii) a nucleotide sequence encoding a 3C protease, capable of cleaving the picornavirus capsid precursor protein, wherein the protease includes a mutation at Cys142 which reduces its capsid precursor protein cleaving activity; and (iii) a control element which controls the expression of the protease
A method performed by a mobile terminal of requesting authorization to use a proximity service, comprising: submitting a request to establish a Packet Data Network, PDN, connection in order to obtain authorization for accessing a proximity service (103, 104); receiving a response indicating to which proximity service function (103, 104) an authorization request should be submitted; and submitting (S303, S304) the proximity service authorization request to the proximity service function (103, 104) indicated in the response, characterized in that said response comprises a destination address of a visiting network proximity service function in a Protocol Configuration Options, PCO, field in case the mobile terminal is roaming and a Packet Data Network Gateway, PGW, from the visiting network is allocated to the connection. submitting a request to establish a Packet Data Network, PDN, connection in order to obtain authorization for accessing a proximity service (103, 104); receiving a response indicating to which proximity service function (103, 104) an authorization request should be submitted; and submitting (S303, S304) the proximity service authorization request to the proximity service function (103, 104) indicated in the response, characterized in that said response comprises a destination address of a visiting network proximity service function in a Protocol Configuration Options, PCO, field in case the mobile terminal is roaming and a Packet Data Network Gateway, PGW, from the visiting network is allocated to the connection.
A computer-implemented method, comprising: receiving a number of occupants on an aircraft; monitoring, by a processing device, ambient conditions on the aircraft; determining an occupant threshold limit for the aircraft based on the ambient conditions; reducing cabin pressure in the aircraft responsive to the number of occupants exceeding the occupant threshold limit; and resetting the cabin pressure in the aircraft responsive to the occupant threshold limit increasing due to changing ambient conditions. receiving a number of occupants on an aircraft; monitoring, by a processing device, ambient conditions on the aircraft; determining an occupant threshold limit for the aircraft based on the ambient conditions; reducing cabin pressure in the aircraft responsive to the number of occupants exceeding the occupant threshold limit; and resetting the cabin pressure in the aircraft responsive to the occupant threshold limit increasing due to changing ambient conditions.
An article of footwear having a footbed, the footbed comprising: a body having a lateral edge, a medial edge, a toe edge, and a heel edge, wherein the lateral edge is located opposite the medial edge and the toe edge is located opposite the heel edge, the body further having a bottom surface and a foot-contacting surface opposite the bottom surface, the foot-contacting surface comprising a layer of cork, portions of the layer of cork having a first thickness and portions of the layer of cork having a second thickness that is less than the first thickness, the first thickness and the second thickness are measured from the bottom surface, wherein the portions having a second thickness form channels traversing the foot-contacting surface such that the portions having a first thickness are surrounded by the channels to form a network of channels covering the foot-contacting surface, wherein the channels traverse the foot-contacting surface from a toe region to a heel region and from a medial region to a lateral region, wherein the network of channels formed by the second thickness portions is non-uniform in distribution across the foot-contacting surface and wherein the portions of the layer of the cork having the second thickness have a lower carbon molecule content than the portions of the layer of cork having the first thickness.
A travel control method for a vehicle, comprising: specifying a pedestrian crosswalk through which a subject vehicle is expected to pass as a first pedestrian crosswalk; estimating a position on the first pedestrian crosswalk through which the subject vehicle passes as a crossing position in a length direction of the first pedestrian crosswalk; characterized by determining (S107, S108) whether or not a second pedestrian crosswalk located within a predetermined first distance from the crossing position and located close to the first pedestrian crosswalk is specified; when the second pedestrian crosswalk is specified, setting an area combining the first pedestrian crosswalk and the second pedestrian crosswalk as an interpolation area; setting an area including the first pedestrian crosswalk, the second pedestrian crosswalk, and the interpolation area as a detection area of a detector detecting an object around the subject vehicle; and controlling travel of the subject vehicle on a basis of a detection result of the detector. specifying a pedestrian crosswalk through which a subject vehicle is expected to pass as a first pedestrian crosswalk; estimating a position on the first pedestrian crosswalk through which the subject vehicle passes as a crossing position in a length direction of the first pedestrian crosswalk; characterized by determining (S107, S108) whether or not a second pedestrian crosswalk located within a predetermined first distance from the crossing position and located close to the first pedestrian crosswalk is specified; when the second pedestrian crosswalk is specified, setting an area combining the first pedestrian crosswalk and the second pedestrian crosswalk as an interpolation area; setting an area including the first pedestrian crosswalk, the second pedestrian crosswalk, and the interpolation area as a detection area of a detector detecting an object around the subject vehicle; and controlling travel of the subject vehicle on a basis of a detection result of the detector.
A method for producing cooling comprising evaporating a liquid refrigerant comprising (a) E -CF 3 CH=CHF and (b) at least one tetrafluoroethane of the formula C 2 H 2 F 4; provided that the weight ratio of E -CF 3 CH=CHF to the total amount of E -CF 3 CH=CHF and C 2 H 2 F 4 is from about 0.05 to 0.82, in an evaporator, thereby producing a refrigerant vapor; wherein the cooling is produced in a chiller comprising said evaporator, further comprising passing a cooling medium through the evaporator, whereby said evaporation of refrigerant cools the cooling medium, and passing the cooled cooling medium from the evaporator to a body to be cooled; and wherein said chiller further comprises a centrifugal compressor; provided that 1. the refrigerant is not a refrigerant comprising from 2 to 20% by weight R-152a, from 5 to 60% by weight R-134a, and from 5 to 85% by weight E -CF 3 CH=CHF; 2. the refrigerant is not a refrigerant comprising E -CF 3 CH=CHF, R-134a and R-32, and 3. the refrigerant is not a refrigerant comprising E -CF 3 CH=CHF, R-134a and R-161. 1. the refrigerant is not a refrigerant comprising from 2 to 20% by weight R-152a, from 5 to 60% by weight R-134a, and from 5 to 85% by weight E -CF 3 CH=CHF; 2. the refrigerant is not a refrigerant comprising E -CF 3 CH=CHF, R-134a and R-32, and 3. the refrigerant is not a refrigerant comprising E -CF 3 CH=CHF, R-134a and R-161.
A method for making a tampon, the method comprising steps of: advancing primary absorbent members in a machine direction, wherein each primary absorbent member comprises a first surface and an opposing second surface extending in the machine direction between a leading edge and a trailing edge, wherein the leading edges of advancing the primary absorbent members are separated from each other in the machine direction by a pitch distance; advancing discrete secondary absorbent members, wherein each discrete secondary absorbent member comprises a first surface and an opposing second surface extending in the machine direction between a leading edge and a trailing edge; separating the leading edges of the advancing discrete secondary absorbent members from each other in the machine direction by the pitch distance; advancing a continuous cord in the machine direction; positioning the continuous cord on the first surface of a first discrete secondary absorbent member; positioning the second surface of the first discrete secondary absorbent member in contact with and in a facing relationship with the first surface of a first primary absorbent member; sewing a thread through the continuous cord, the first discrete secondary absorbent member, and the first primary absorbent member. advancing primary absorbent members in a machine direction, wherein each primary absorbent member comprises a first surface and an opposing second surface extending in the machine direction between a leading edge and a trailing edge, wherein the leading edges of advancing the primary absorbent members are separated from each other in the machine direction by a pitch distance; advancing discrete secondary absorbent members, wherein each discrete secondary absorbent member comprises a first surface and an opposing second surface extending in the machine direction between a leading edge and a trailing edge; separating the leading edges of the advancing discrete secondary absorbent members from each other in the machine direction by the pitch distance; advancing a continuous cord in the machine direction; positioning the continuous cord on the first surface of a first discrete secondary absorbent member; positioning the second surface of the first discrete secondary absorbent member in contact with and in a facing relationship with the first surface of a first primary absorbent member; sewing a thread through the continuous cord, the first discrete secondary absorbent member, and the first primary absorbent member.
A temperature sensor comprising: a sensor element (2, 4, 5) comprising a temperature sensing element whose electrical resistance changes according to temperature; a pair of lead wires electrically connected to the temperature sensing element; and a covering material which seals the temperature sensing element and the lead wires; wherein the lead wires are led out of sealed ends of the covering material; a metallic protective tube which houses the sensor element (2, 4, 5) except part of the lead wires; and a shield (7, 8; 26; 36; 38) made of ceramic comprising a sealed end closing section, the sealed end closing section being present between the temperature sensing element and the metallic protective tube and enclosing the sealed ends, and a lead wire protective section having through holes; the lead wires taken out of the sealed ends being configured to pierce through said through holes, characterized in that the shield (26, 36, 38) is loosely fitted inside the metallic protective tube. a sensor element (2, 4, 5) comprising a temperature sensing element whose electrical resistance changes according to temperature; a pair of lead wires electrically connected to the temperature sensing element; and a covering material which seals the temperature sensing element and the lead wires; wherein the lead wires are led out of sealed ends of the covering material; a metallic protective tube which houses the sensor element (2, 4, 5) except part of the lead wires; and a shield (7, 8; 26; 36; 38) made of ceramic comprising a sealed end closing section, the sealed end closing section being present between the temperature sensing element and the metallic protective tube and enclosing the sealed ends, and a lead wire protective section having through holes; the lead wires taken out of the sealed ends being configured to pierce through said through holes, characterized in that the shield (26, 36, 38) is loosely fitted inside the metallic protective tube.
A process for the preparation of lactic acid and 2-hydroxy-3-butenoic acid or esters thereof from a sugar in the presence of a metallo-silicate material, a metal ion and a solvent, said process comprising contacting the sugar with a metallo-silicate material, wherein the metal ion is selected from one or more of the group consisting of potassium ions, sodium ions, lithium ions, rubidium ions and caesium ions.
A collimator (4, 5, 6) comprising a base (40, 50, 60) and a plurality of side walls (41, 42, 43, 51, 52, 53, 61, 62) arranged to enclose a light source, whereby at least one side wall (41, 51, 61) of the collimator (4, 5, 6) is joined to the base by an integral hinge and is realized to be tiltable within a range of motion (M 4, M 5, M 6), and wherein the base (40, 50, 60) and the side walls (41, 42, 43, 51, 52, 53, 61, 62) of the collimator (4, 5, 6) are realized so that light emitted by the light source enters the collimator (4, 5, 6) through a light entry opening and exits essentially only through a light exit opening for any position of the hinged side wall (41, 51, 61) over its range of motion (M 4, M 5, M 6), characterized in that, the at least one side wall (41, 51, 61) and the base (40, 50, 60) are made of one piece, and the integral hinge preferably comprises a region of reduced material thickness between the hinged side wall (41, 51, 61) and the base (40, 50, 60) of the collimator (4, 5, 6).
A medicament comprising an antagonist of a Programmed Death 1 protein (PD-1) in combination with a dinaciclib compound for use in treating a cancer in an individual, wherein the dinaciclib compound is the compound of Formula I or a pharmaceutically acceptable salt of the compound of Formula I wherein the PD-1 antagonist is an anti-PD-1 monoclonal antibody which comprises a heavy chain and a light chain, wherein the heavy and light chains comprise SEQ ID NO:21 and SEQ ID NO:22, respectively.
A fly-by-wire flight control system, comprising: a pilot control assembly having a beep switch; a rotorcraft flight control computer having a control law, the control law operable, in response to deflection of the beep switch by a pilot, to engage a rated turn of the rotorcraft which corresponds to a roll maneuver when the rotorcraft is operating at a forward airspeed greater than about 35-40 knots, and to a yaw maneuver when the rotorcraft is operating at a forward airspeed less than about 35-40 knots. a pilot control assembly having a beep switch; a rotorcraft flight control computer having a control law, the control law operable, in response to deflection of the beep switch by a pilot, to engage a rated turn of the rotorcraft which corresponds to a roll maneuver when the rotorcraft is operating at a forward airspeed greater than about 35-40 knots, and to a yaw maneuver when the rotorcraft is operating at a forward airspeed less than about 35-40 knots.
A low sulfur marine distillate fuel trunk piston diesel engine lubricating oil composition comprising: (a) a major amount of a Group I base oil or a Group II base oil or mixtures thereof; (b) at least one or more detergents comprising at least one overbased salt of an alkyl-substituted hydroxybenzoic acid; and (c) a succinimide dispersant derived from polyalkylene having a number average molecular weight (Mn) of 1400-3000; wherein the alkyl groups of the overbased salt of an alkyl-substituted hydroxybenzoic acid, are at least 90 mole % C 20 or greater; and wherein the succinimide dispersant is present at greater than 1.2 wt. % on an actives basis; and the total base number of the low sulfur marine distillate fuel trunk piston diesel engine lubrication oil composition is less than 30 mg KOH/g, measured in accordance with ASTM Standard No. D2896. (a) a major amount of a Group I base oil or a Group II base oil or mixtures thereof; (b) at least one or more detergents comprising at least one overbased salt of an alkyl-substituted hydroxybenzoic acid; and (c) a succinimide dispersant derived from polyalkylene having a number average molecular weight (Mn) of 1400-3000; wherein the alkyl groups of the overbased salt of an alkyl-substituted hydroxybenzoic acid, are at least 90 mole % C 20 or greater; and wherein the succinimide dispersant is present at greater than 1.2 wt. % on an actives basis; and the total base number of the low sulfur marine distillate fuel trunk piston diesel engine lubrication oil composition is less than 30 mg KOH/g, measured in accordance with ASTM Standard No. D2896.
An impregnated drill bit comprising: a shank having a first end and an opposing second end, said first end being adapted to be secured to a drill string component; a crown extending from said second end of said shank, said crown including a matrix of hard particulate material a cutting face, and a crown body between said cutting face and said shank; a first plurality of abrasive cutting media having at least one dimension between about 2.5 millimeters and about 5 millimeters, said first plurality of abrasive cutting media being positioned in an unorganized arrangement throughout a first portion of said crown body adjacent said cutting face; and a second plurality of abrasive cutting media having a largest dimension less than about 2 millimeters, said second plurality of abrasive cutting media being dispersed throughout a second portion of said crown body between said first portion of said crown body and said shank. a shank having a first end and an opposing second end, said first end being adapted to be secured to a drill string component; a crown extending from said second end of said shank, said crown including a matrix of hard particulate material a cutting face, and a crown body between said cutting face and said shank; a first plurality of abrasive cutting media having at least one dimension between about 2.5 millimeters and about 5 millimeters, said first plurality of abrasive cutting media being positioned in an unorganized arrangement throughout a first portion of said crown body adjacent said cutting face; and a second plurality of abrasive cutting media having a largest dimension less than about 2 millimeters, said second plurality of abrasive cutting media being dispersed throughout a second portion of said crown body between said first portion of said crown body and said shank.
Exercise device comprising at least one curved track comprising a first section with curvature of a first sign, a carriage mounted movably on the at least one track and adapted to support the body of a user, characterised in that the curved track comprises a second section with a curvature of opposite sign to the first sign, the second section following the first section, wherein the dual curvature is "S" or "reverse-S" shaped, and has an inclination, and a magnitude of the curvature of the second section is greater than a magnitude of the curvature of the first section, wherein, when the exercise device is in its position of use, the first section is at a lower end of the track, nearest the ground, and the second section is at an upper end of the track, whereby a resistance to an exercise movement depends on a carriage position along the track, and the weight of the user.
A hemostatic powder comprising a chitosan salt of an organic acid together with at least one inert material, wherein the at least one inert material comprises one or more of the group consisting of: cellulose, fumed silica, sand, clay, alginate, micro crystalline cellulose, oxidised regenerated cellulose, polyethylglycol, guar gum, xanthan gum, chitosan, chitosan derivatives, chitin, sucrose, lactose, pectin, carboxymethylcellulose, ground corn meal, collagen, gelataine, polyvinylalcohol, acrylic acid, crosslinked acrylic acid-based polymers, barium sulphate, starch.
A refrigeration system that includes a free cooling system with a first circuit configured to transfer heat from a first cooling fluid to a second cooling fluid circulating within an independent loop of the free cooling system, wherein the independent loop is configured to transfer heat from the second cooling fluid to ambient air, the refrigeration system comprising a compressor configured to compress a refrigerant, a condenser configured to receive and to condense the compressed refrigerant, an expansion device configured to reduce pressure of the condensed refrigerant, and an evaporator configured to evaporate the refrigerant by absorbing heat from the first cooling fluid prior to returning the refrigerant to the compressor, the refrigeration system and a heat exchanger configured to receive the refrigerant and to transfer heat from the refrigerant to the second cooling fluid, characterized in that the heat exchanger comprises a three-fluid heat exchanger configured to transfer heat from the first cooling fluid to the second cooling fluid and to transfer heat from the refrigerant to the second cooling fluid.
A rotor for an electric machine having: an active part and at least a shaft with a chamber containing a conductor, at least a hole connected to the chamber and opening to the outside of the rotor, the at least a hole housing a conductive stalk having a part connected to the conductor and another part protruding from the rotor, two seals being provided between the conductive stalk and the rotor to prevent gas from entering the at least a hole, wherein the two seals act upon directions perpendicular to a hole longitudinal axis and are defined each by an O-ring (27, 28), the rotor defines a seat at the outlet of the at least a hole, and characterised in that an insulating element is provided between the conductive stalk and the rotor; the insulating element being housed in the seat, an O-ring is provided between the insulating element and surfaces of the seat parallel to the hole longitudinal axis, the other O-ring is provided between the insulating element and surfaces of the conductive stalk parallel to the hole longitudinal axis. an active part and at least a shaft with a chamber containing a conductor, at least a hole connected to the chamber and opening to the outside of the rotor, the at least a hole housing a conductive stalk having a part connected to the conductor and another part protruding from the rotor, two seals being provided between the conductive stalk and the rotor to prevent gas from entering the at least a hole, wherein the two seals act upon directions perpendicular to a hole longitudinal axis and are defined each by an O-ring (27, 28), the rotor defines a seat at the outlet of the at least a hole, and characterised in that an insulating element is provided between the conductive stalk and the rotor; the insulating element being housed in the seat, an O-ring is provided between the insulating element and surfaces of the seat parallel to the hole longitudinal axis, the other O-ring is provided between the insulating element and surfaces of the conductive stalk parallel to the hole longitudinal axis.