A device useful for delivering drugs to the respiratory system of a user, said device comprising: a. an air controlling mechanism comprising a shutter (14, 163) for interrupting the passage of air during inhalation or exhalation of said air; b. at least one container for storing said drugs; c. a drug releasing mechanism for delivering said drugs from said container to said user; wherein said air controlling mechanism is adapted to generate pressure pulses of Negative Pressure or Positive Pressure into said respiratory system during inspiration or expiration, wherein said drug releasing mechanism is adapted for entraining said drugs into said pressure pulses, such that uptake of said drugs by the tissues of said respiratory system is facilitated; wherein said pressure pulses are selected from the group consisting of: inspiratory Negative Pressure pulses, inspiratory Positive Pressure pulses, expiratory Negative Pressure pulses, expiratory Positive Pressure pulses into said respiratory system, and any combination thereof, characterized in that the shutter (14, 163) comprises a perforated rotating disc adapted to allow passage of the air through the perforation within the disc and to block and unblock the passage of the air, wherein i) the rotating disc is configured to be driven by the rotation of a wheel which is adapted to be rotated when the user is inhaling air or exhaling air, or ii) the rotating disc is configured to be driven by rotation of a switch which is adapted to provide potential energy to a spring so as to control the closing/opening of the shutter (14, 163) when the potential energy of the spring is released, or in that the air controlling mechanism comprises a rotating cogwheel, configured to be rotationally actuated by the passage of air within a tubule, wherein each rotation of the cogwheel is translated into opening and closing of shutter (14, 163). a. an air controlling mechanism comprising a shutter (14, 163) for interrupting the passage of air during inhalation or exhalation of said air; b. at least one container for storing said drugs; c. a drug releasing mechanism for delivering said drugs from said container to said user; wherein said air controlling mechanism is adapted to generate pressure pulses of Negative Pressure or Positive Pressure into said respiratory system during inspiration or expiration, wherein said drug releasing mechanism is adapted for entraining said drugs into said pressure pulses, such that uptake of said drugs by the tissues of said respiratory system is facilitated; wherein said pressure pulses are selected from the group consisting of: inspiratory Negative Pressure pulses, inspiratory Positive Pressure pulses, expiratory Negative Pressure pulses, expiratory Positive Pressure pulses into said respiratory system, and any combination thereof, characterized in that the shutter (14, 163) comprises a perforated rotating disc adapted to allow passage of the air through the perforation within the disc and to block and unblock the passage of the air, wherein i) the rotating disc is configured to be driven by the rotation of a wheel which is adapted to be rotated when the user is inhaling air or exhaling air, or ii) the rotating disc is configured to be driven by rotation of a switch which is adapted to provide potential energy to a spring so as to control the closing/opening of the shutter (14, 163) when the potential energy of the spring is released, or in that the air controlling mechanism comprises a rotating cogwheel, configured to be rotationally actuated by the passage of air within a tubule, wherein each rotation of the cogwheel is translated into opening and closing of shutter (14, 163). i) the rotating disc is configured to be driven by the rotation of a wheel which is adapted to be rotated when the user is inhaling air or exhaling air, or ii) the rotating disc is configured to be driven by rotation of a switch which is adapted to provide potential energy to a spring so as to control the closing/opening of the shutter (14, 163) when the potential energy of the spring is released,