A stress prediction device for predicting mechanical stress exerted to a deformable object due to mechanical contact between the object and an external device that is to be inserted into the object and to be positioned at a pre-determined intended insertion position, comprising: a segmentation unit, which is configured - to access generic model data (104, 200), which represents a three-dimensional generic reference object comprising predefined secondary landmark features at predefined landmark positions, which are not identifiable using a predefined imaging technique, and which comprises spatially resolved mechanical reference data representing at least one mechanical property of the generic reference object, and to access pre-insertion object image data acquired using the imaging technique and representing a three-dimensional image of the object prior to insertion of the external device; - using the pre-insertion object image data and the generic model data, to provide segmented object model data (106, 214) which represents the object and its spatially resolved mechanical property and comprises associated mapped landmark position data indicative of mapped landmark positions of the secondary landmark features within the object; and comprising: a stress determination unit, which is configured - to receive insertion position data indicative of the intended insertion position, and device model data, which represents the external device, and - to calculate and provide, using the segmented object model data, the device model data and the intended insertion position data predictive stress information indicative of mechanical stress exerted to at least one of the secondary landmark features at the associated mapped landmark position due to mechanical contact between the object and the external device when inserted into the object at the intended insertion position. a segmentation unit, which is configured - to access generic model data (104, 200), which represents a three-dimensional generic reference object comprising predefined secondary landmark features at predefined landmark positions, which are not identifiable using a predefined imaging technique, and which comprises spatially resolved mechanical reference data representing at least one mechanical property of the generic reference object, and to access pre-insertion object image data acquired using the imaging technique and representing a three-dimensional image of the object prior to insertion of the external device; - using the pre-insertion object image data and the generic model data, to provide segmented object model data (106, 214) which represents the object and its spatially resolved mechanical property and comprises associated mapped landmark position data indicative of mapped landmark positions of the secondary landmark features within the object; and comprising: - to access generic model data (104, 200), which represents a three-dimensional generic reference object comprising predefined secondary landmark features at predefined landmark positions, which are not identifiable using a predefined imaging technique, and which comprises spatially resolved mechanical reference data representing at least one mechanical property of the generic reference object, and to access pre-insertion object image data acquired using the imaging technique and representing a three-dimensional image of the object prior to insertion of the external device; - using the pre-insertion object image data and the generic model data, to provide segmented object model data (106, 214) which represents the object and its spatially resolved mechanical property and comprises associated mapped landmark position data indicative of mapped landmark positions of the secondary landmark features within the object; and comprising: a stress determination unit, which is configured - to receive insertion position data indicative of the intended insertion position, and device model data, which represents the external device, and - to calculate and provide, using the segmented object model data, the device model data and the intended insertion position data predictive stress information indicative of mechanical stress exerted to at least one of the secondary landmark features at the associated mapped landmark position due to mechanical contact between the object and the external device when inserted into the object at the intended insertion position. - to receive insertion position data indicative of the intended insertion position, and device model data, which represents the external device, and - to calculate and provide, using the segmented object model data, the device model data and the intended insertion position data predictive stress information indicative of mechanical stress exerted to at least one of the secondary landmark features at the associated mapped landmark position due to mechanical contact between the object and the external device when inserted into the object at the intended insertion position.