A process for the pre-treatment of a crude tall oil for removal of impurities, said process comprising a first pre-treatment step involving a CTO wash, wherein the CTO is contacted with water in an amount of below 5 wt.% on incoming CTO for the CTO wash, and a separation of a first oil phase comprising refined CTO and an aqueous phase holding impurities, wherein the separation of the first pre-treatment step is performed in a separator unit where the separation is driven by centrifugal force, and a second step involving a separation of a second oil phase from the aqueous phase, wherein the recovered second oil phase is fed into the first oil phase comprising refined CTO or the recovered second oil phase is fed into the CTO, wherein the refined CTO is fed into a process system providing separation of volatile components having boiling points below 170°C present in the refined CTO to provide a volatile depleted tall oil stream, wherein the refined CTO is further treated in a process comprising fractionation under vacuum of the refined CTO into at least one stream of refined tall diesel or tall oil fatty acids (TOFA), said RTD or TOFA comprising from 2 - 40 % by volume of resin acids and from 20 - 90 % by volume of fatty acids, and at least one stream of resin acid(s) comprising less than 5 % by volume of fatty acids, and wherein before fractioning under vacuum into at least one stream of refined tall diesel or tall oil fatty acid (TOFA) and at least one stream of resin acid(s), the volatile depleted tall oil stream is treated under vacuum to separate high-boiling point CTO components as a liquid stream, tall oil pitch, from a gaseous stream comprising fatty and resin acids. a first pre-treatment step involving a CTO wash, wherein the CTO is contacted with water in an amount of below 5 wt.% on incoming CTO for the CTO wash, and a separation of a first oil phase comprising refined CTO and an aqueous phase holding impurities, wherein the separation of the first pre-treatment step is performed in a separator unit where the separation is driven by centrifugal force, and a second step involving a separation of a second oil phase from the aqueous phase, wherein the recovered second oil phase is fed into the first oil phase comprising refined CTO or the recovered second oil phase is fed into the CTO, wherein the refined CTO is fed into a process system providing separation of volatile components having boiling points below 170°C present in the refined CTO to provide a volatile depleted tall oil stream, wherein the refined CTO is further treated in a process comprising fractionation under vacuum of the refined CTO into at least one stream of refined tall diesel or tall oil fatty acids (TOFA), said RTD or TOFA comprising from 2 - 40 % by volume of resin acids and from 20 - 90 % by volume of fatty acids, and at least one stream of resin acid(s) comprising less than 5 % by volume of fatty acids, and wherein before fractioning under vacuum into at least one stream of refined tall diesel or tall oil fatty acid (TOFA) and at least one stream of resin acid(s), the volatile depleted tall oil stream is treated under vacuum to separate high-boiling point CTO components as a liquid stream, tall oil pitch, from a gaseous stream comprising fatty and resin acids.