A compound of Formula III, or a physiological salt thereof for use in therapy, wherein: R 8 is -H, a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl; R 9 is -H, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted heteroaryl or a substituted or unsubstituted heteroaralkyl; R 10 is substituted or unsubstituted phenyl, C 1 -C 12 -alkyl substituted with heteroaryl group, C 1 -C 12 -alkyl substituted a heterocycloalkyl group, or C 1 -C 12 -alkyl substituted with -NR 13 R 14; R 11 is a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted C 3 -C 8 -cycloalkyl-C 1 -C 12 - alkyl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heteroaralkyl, or a substituted or unsubstituted benzophenone; R 12 is H; wherein one or more substituents of C 1 -C 12 -alkyl, cycloalkyl, the C 1 -C 12 -alkyl portion of an aralkyl, the C 1 -C 12 -alkyl portion of an heteroaralkyl and C 3 -C 8 -cycloalkylC 1 -C 12 -alkyl are independently selected from halo, C 1 -C 6 -alkyl, nitro, hydroxyl, cyano, aryl, C 3 -C 8 cycloalkyl, heteroaryl, -NR 13 R 14 and -C R 15, wherein R 15 is -H, C 1 -C 6 -alkyl, an aryl or an aralkyl; wherein one or more substituents of aryl, heteroaryl, benzophenone, aromatic portion of aralkyl and aromatic portion of heteroaralkyl are independently selected from halo, C 1 -C 3 -alkyl, halogenated C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy, aromatic ether, C 1 -C 3 -alkyl_substituted with an aromatic ether, a hydroxy substituted C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy substituted aromatic ether, -S-C 1 -C 3 -alkyl, cyano, azide, nitro, -C R 15,-NR 13 R 14, -C NR 13 R 14, -C OR 16, wherein R 16 is-H, an C 1 -C 3 -alkyl, an aryl or an aralkyl; benzyl, 4-(4-benzylpiperazin-1-yl) methyl, 4-4- (2-fluorophenyl) piperazin-1-yl) methyl, a halogenated aryl, methylenedioxo, an aryl, a heteroaralkyl, a heterocycloalkyl-C 1 -C 3 alkyl, and a heteroaryl group; and R 13 and R 14 are each, independently, -H, a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted C 3 -C 8 -cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl; or R 13 and R 14 together with the nitrogen to which they are attached are a heterocycloalkyl; R 8 is -H, a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl; R 9 is -H, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted heteroaryl or a substituted or unsubstituted heteroaralkyl; R 10 is substituted or unsubstituted phenyl, C 1 -C 12 -alkyl substituted with heteroaryl group, C 1 -C 12 -alkyl substituted a heterocycloalkyl group, or C 1 -C 12 -alkyl substituted with -NR 13 R 14; R 11 is a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted C 3 -C 8 -cycloalkyl-C 1 -C 12 - alkyl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heteroaralkyl, or a substituted or unsubstituted benzophenone; R 12 is H; wherein one or more substituents of C 1 -C 12 -alkyl, cycloalkyl, the C 1 -C 12 -alkyl portion of an aralkyl, the C 1 -C 12 -alkyl portion of an heteroaralkyl and C 3 -C 8 -cycloalkylC 1 -C 12 -alkyl are independently selected from halo, C 1 -C 6 -alkyl, nitro, hydroxyl, cyano, aryl, C 3 -C 8 cycloalkyl, heteroaryl, -NR 13 R 14 and -C R 15, wherein R 15 is -H, C 1 -C 6 -alkyl, an aryl or an aralkyl; wherein one or more substituents of aryl, heteroaryl, benzophenone, aromatic portion of aralkyl and aromatic portion of heteroaralkyl are independently selected from halo, C 1 -C 3 -alkyl, halogenated C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy, aromatic ether, C 1 -C 3 -alkyl_substituted with an aromatic ether, a hydroxy substituted C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy substituted aromatic ether, -S-C 1 -C 3 -alkyl, cyano, azide, nitro, -C R 15,-NR 13 R 14, -C NR 13 R 14, -C OR 16, wherein R 16 is-H, an C 1 -C 3 -alkyl, an aryl or an aralkyl; benzyl, 4-(4-benzylpiperazin-1-yl) methyl, 4-4- (2-fluorophenyl) piperazin-1-yl) methyl, a halogenated aryl, methylenedioxo, an aryl, a heteroaralkyl, a heterocycloalkyl-C 1 -C 3 alkyl, and a heteroaryl group; and R 13 and R 14 are each, independently, -H, a substituted or unsubstituted C 1 -C 12 -alkyl, a substituted or unsubstituted C 3 -C 8 -cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aralkyl; or R 13 and R 14 together with the nitrogen to which they are attached are a heterocycloalkyl;