An endoscopic surgical system comprising: an endoscope including an insertion portion, wherein position/attitude operation of the insertion portion including an insertion operation and a rotation operation of the insertion portion is performable; a surgical instrument configured to be inserted into a channel of the endoscope and configured to treat an analyte; surgical instrument powering means configured to actively actuate the surgical instrument to perform position/attitude operation of the surgical instrument including an insertion operation and a rotation operation of the surgical instrument; control means which controls the surgical instrument powering means; and surgical instrument instruction input means which transmits an instruction input signal to the control means, surgical instrument position/attitude information acquisition means for acquiring position/attitude information of the surgical instrument and for transmitting the position/attitude information of the surgical instrument to the control means; and endoscope position/attitude information acquisition means configured to acquire position/attitude information of the endoscope and configured to transmit the position/attitude information of the insertion portion to the control means, wherein the position/attitude information of the insertion portion includes an insertion amount and a rotation amount of the insertion portion, characterized in that the control means includes control signal adjusting means configured to adjust a control signal of the surgical instrument powering means by utilizing the position/attitude information of the endoscope acquired by the endoscope position/attitude information acquisition means when the surgical instrument is inserted into the channel such that the surgical instrument can be operated independently from the endoscope and the position/attitude of the endoscope can be operated without changing a relative position/attitude of the surgical instrument with respect to an affected area. an endoscope including an insertion portion, wherein position/attitude operation of the insertion portion including an insertion operation and a rotation operation of the insertion portion is performable; a surgical instrument configured to be inserted into a channel of the endoscope and configured to treat an analyte; surgical instrument powering means configured to actively actuate the surgical instrument to perform position/attitude operation of the surgical instrument including an insertion operation and a rotation operation of the surgical instrument; control means which controls the surgical instrument powering means; and surgical instrument instruction input means which transmits an instruction input signal to the control means, surgical instrument position/attitude information acquisition means for acquiring position/attitude information of the surgical instrument and for transmitting the position/attitude information of the surgical instrument to the control means; and endoscope position/attitude information acquisition means configured to acquire position/attitude information of the endoscope and configured to transmit the position/attitude information of the insertion portion to the control means, wherein the position/attitude information of the insertion portion includes an insertion amount and a rotation amount of the insertion portion, characterized in that the control means includes control signal adjusting means configured to adjust a control signal of the surgical instrument powering means by utilizing the position/attitude information of the endoscope acquired by the endoscope position/attitude information acquisition means when the surgical instrument is inserted into the channel such that the surgical instrument can be operated independently from the endoscope and the position/attitude of the endoscope can be operated without changing a relative position/attitude of the surgical instrument with respect to an affected area.