An electro-chemical surgical instrument for use in surgery for cutting, cauterizing, and/or chemically removing a target tissue in an operating site, said electro-chemical surgical instrument comprising: a chemically assisted mechanical dissector for removing a target tissue, comprising: (a) a conductive mechanical instrument coupled to a distal end of, (b) a tube (It) which is non-conductive and extends over a length, L1, measured parallel to a longitudinal axis, Z, from a proximal end to the distal end; (c) a source of a cleavage solution able to break disulphide bonds of polypeptide chains and proteins, which is fluidly coupled through a pump to an inlet of, (d) a channel extending from an inlet to one or more channel outlets, having a housed portion of length, L2, which is housed in the tube with said one or more channel outlets being located at or adjacent to the distal end, such as to allow the wetting of a lateral surface of the conductive mechanical instrument with the cleavage solution when the pump is activated; (e) a flow controller configured for activating the pump and thus feeding the cleavage solution to the channel outlet; and an electric knife for cutting and/or cauterizing a target tissue, comprising: (f) an electric conductor extending from a connection end comprising a connector for connecting the electric conductor to a source of high frequency AC electrical power, for feeding electric power to an electrode end comprising an electrode formed by the conductive mechanical instrument, wherein a portion of said electric conductor is housed in the tube; (g) an electric controller configured for controlling the feeding of current to the electrode. a chemically assisted mechanical dissector for removing a target tissue, comprising: (a) a conductive mechanical instrument coupled to a distal end of, (b) a tube (It) which is non-conductive and extends over a length, L1, measured parallel to a longitudinal axis, Z, from a proximal end to the distal end; (c) a source of a cleavage solution able to break disulphide bonds of polypeptide chains and proteins, which is fluidly coupled through a pump to an inlet of, (d) a channel extending from an inlet to one or more channel outlets, having a housed portion of length, L2, which is housed in the tube with said one or more channel outlets being located at or adjacent to the distal end, such as to allow the wetting of a lateral surface of the conductive mechanical instrument with the cleavage solution when the pump is activated; (e) a flow controller configured for activating the pump and thus feeding the cleavage solution to the channel outlet; and (a) a conductive mechanical instrument coupled to a distal end of, (b) a tube (It) which is non-conductive and extends over a length, L1, measured parallel to a longitudinal axis, Z, from a proximal end to the distal end; (c) a source of a cleavage solution able to break disulphide bonds of polypeptide chains and proteins, which is fluidly coupled through a pump to an inlet of, (d) a channel extending from an inlet to one or more channel outlets, having a housed portion of length, L2, which is housed in the tube with said one or more channel outlets being located at or adjacent to the distal end, such as to allow the wetting of a lateral surface of the conductive mechanical instrument with the cleavage solution when the pump is activated; (e) a flow controller configured for activating the pump and thus feeding the cleavage solution to the channel outlet; and an electric knife for cutting and/or cauterizing a target tissue, comprising: (f) an electric conductor extending from a connection end comprising a connector for connecting the electric conductor to a source of high frequency AC electrical power, for feeding electric power to an electrode end comprising an electrode formed by the conductive mechanical instrument, wherein a portion of said electric conductor is housed in the tube; (g) an electric controller configured for controlling the feeding of current to the electrode. (f) an electric conductor extending from a connection end comprising a connector for connecting the electric conductor to a source of high frequency AC electrical power, for feeding electric power to an electrode end comprising an electrode formed by the conductive mechanical instrument, wherein a portion of said electric conductor is housed in the tube; (g) an electric controller configured for controlling the feeding of current to the electrode.