A multi-connector apparatus with connection-sequence interlocking, comprising: at least one make-first/break-last connector; at least one make-last/break-first connector; a connector header having at least first and second connector bays (14, 18) configured to receive said make-first/break-last and make-last/break-first connectors (16, 20), respectively; an interlock plate movably affixed to said connector header for covering selected portions of said first and second connector bays (14, 18) to prevent or allow insertion and removal of said make-first/break-last and make-last/break-first connectors (16, 20), said interlock plate having a base position that allows insertion of said make-first/break-last connector into said first connector bay while preventing insertion of said make-last/break-first connector into said second connector bay, and a shifted position that prevents removal of an inserted make-first/break-last connector from said first connector bay while allowing insertion of said make-last/break-first connector into said second connector bay; a locking mechanism (40, 42, 44) for holding said interlock plate in said base position prior to insertion of said make-first/break-last connector into said first connector bay; and said locking mechanism comprises a tab depending from a frame of said interlock plate; characterized in that said locking mechanism further comprises a slot formed in a sidewall of said connector header in which said depending tab seats; and in that said make-first/break-last connector includes an outwardly depending projection that engages said depending tab when said make-first/break-last connector is inserted into said first connector bay to release said locking mechanism (40, 42, 44) and allow movement of said interlock plate to said shifted position. at least one make-first/break-last connector; at least one make-last/break-first connector; a connector header having at least first and second connector bays (14, 18) configured to receive said make-first/break-last and make-last/break-first connectors (16, 20), respectively; an interlock plate movably affixed to said connector header for covering selected portions of said first and second connector bays (14, 18) to prevent or allow insertion and removal of said make-first/break-last and make-last/break-first connectors (16, 20), said interlock plate having a base position that allows insertion of said make-first/break-last connector into said first connector bay while preventing insertion of said make-last/break-first connector into said second connector bay, and a shifted position that prevents removal of an inserted make-first/break-last connector from said first connector bay while allowing insertion of said make-last/break-first connector into said second connector bay; a locking mechanism (40, 42, 44) for holding said interlock plate in said base position prior to insertion of said make-first/break-last connector into said first connector bay; and said locking mechanism comprises a tab depending from a frame of said interlock plate; characterized in that said locking mechanism further comprises a slot formed in a sidewall of said connector header in which said depending tab seats; and in that said make-first/break-last connector includes an outwardly depending projection that engages said depending tab when said make-first/break-last connector is inserted into said first connector bay to release said locking mechanism (40, 42, 44) and allow movement of said interlock plate to said shifted position.