A compound having a structure of Formula 4b: or a pharmaceutically acceptable salt thereof, wherein: each of R 1, R 2, R 3, R 4, R 5, R 6, R 7, and R 8 is independently H, alkyl, straight-chain alkyl, branched alkyl, cycloalkyl, branched cyclic alkyl, substituted alkyl, halogen-substituted alkyl, alkoxy, (CH 2) 0-10 -OH, amine, -NH 2, -NH-alkyl, -(CH 2) 1-6 -NH 2, thioalkyl, substituted cycloalkyl, halogen-substituted cycloalkyl, cycloalkoxy, cycloalkylamine, halogen, amide, alkylamide, cyano, methyl carbonitrile, -S 2 CH 3, sulfonyl, carbocyclic ring, aromatic ring, substituted aromatic ring, substituted or non-substituted heterocyclic aromatic ring, substituted or non-substituted heterocyclic non-aromatic ring, carbocyclic or heterocyclic aromatic ring comprising carbon atoms and one or more nitrogen, oxygen and/or sulfur members fused to another aromatic ring, or a multi-ring system comprising a combination of elements selected from aromatic rings, cycloalkyl, heterocyclic rings, alkyl chains, and suitable C-, N-, O-, S-, and/or halogen-containing substituents; each of E and G is independently C or N, wherein each of E and G is independently optionally substituted with R 6; L is absent, alkylene, -O-, or oxyalkylene; and Y is N or C, wherein when Y is C the Y position may be substituted with R a, wherein R a is alkyl, branched alkyl, straight chain alkyl, cycloalkyl, heteroalkyl, alkyl-substituted aryl, substituted alkyl, halo-substituted alkyl, (CH 2) 0-10 -OH, alkoxy, substituted or non-substituted aryl, aromatic or non-aromatic heterocycle, amino, -NH-alkyl, -(CH 2) 1-6 -NH 2, cyano, or sulfonyl, wherein each substituted group is independently substituted with one or more groups selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, hydroxyl, alkoxy, mercaptyl, cyano, halo, isocyanato, thiocyanato, isothiocyanato, nitro, -C R, -OC R,-C OR, -OC NHR, -C N 2, -SR, -S(=O)R, -S(=O) 2 R, -NHR, -N 2, -S(=O) 2 NHR,-S 2 N 2, -NHS 2 R, halo-substituted C 1-6 alkyl, and halo-substituted C 1-6 alkoxy, wherein each R is independently selected from H, halo, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo-substituted C 1-6 alkyl, and halo-substituted C 1-6 alkoxy. each of R 1, R 2, R 3, R 4, R 5, R 6, R 7, and R 8 is independently H, alkyl, straight-chain alkyl, branched alkyl, cycloalkyl, branched cyclic alkyl, substituted alkyl, halogen-substituted alkyl, alkoxy, (CH 2) 0-10 -OH, amine, -NH 2, -NH-alkyl, -(CH 2) 1-6 -NH 2, thioalkyl, substituted cycloalkyl, halogen-substituted cycloalkyl, cycloalkoxy, cycloalkylamine, halogen, amide, alkylamide, cyano, methyl carbonitrile, -S 2 CH 3, sulfonyl, carbocyclic ring, aromatic ring, substituted aromatic ring, substituted or non-substituted heterocyclic aromatic ring, substituted or non-substituted heterocyclic non-aromatic ring, carbocyclic or heterocyclic aromatic ring comprising carbon atoms and one or more nitrogen, oxygen and/or sulfur members fused to another aromatic ring, or a multi-ring system comprising a combination of elements selected from aromatic rings, cycloalkyl, heterocyclic rings, alkyl chains, and suitable C-, N-, O-, S-, and/or halogen-containing substituents; each of E and G is independently C or N, wherein each of E and G is independently optionally substituted with R 6; L is absent, alkylene, -O-, or oxyalkylene; and Y is N or C, wherein when Y is C the Y position may be substituted with R a, wherein R a is alkyl, branched alkyl, straight chain alkyl, cycloalkyl, heteroalkyl, alkyl-substituted aryl, substituted alkyl, halo-substituted alkyl, (CH 2) 0-10 -OH, alkoxy, substituted or non-substituted aryl, aromatic or non-aromatic heterocycle, amino, -NH-alkyl, -(CH 2) 1-6 -NH 2, cyano, or sulfonyl, wherein each substituted group is independently substituted with one or more groups selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, hydroxyl, alkoxy, mercaptyl, cyano, halo, isocyanato, thiocyanato, isothiocyanato, nitro, -C R, -OC R,-C OR, -OC NHR, -C N 2, -SR, -S(=O)R, -S(=O) 2 R, -NHR, -N 2, -S(=O) 2 NHR,-S 2 N 2, -NHS 2 R, halo-substituted C 1-6 alkyl, and halo-substituted C 1-6 alkoxy, wherein each R is independently selected from H, halo, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo-substituted C 1-6 alkyl, and halo-substituted C 1-6 alkoxy.