A preamplifier circuit for amplification of a signal, the preamplifier circuit comprising: an amplifier arranged in a first current path between an input node (In) and an output node (Out) of the preamplifier circuit; a feedback capacitor (Cf) arranged in a second current path between said input node (In) and said output node (Out); a feedback circuit having an adjustable transfer function arranged in a third current path between said input node (In) and said output node (Out); a reset switch ( S 2) arranged in said third current path to enable selectively coupling the output of the feedback circuit to the input of the amplifier and decoupling the output of the feedback circuit from the input of the amplifier; and a loop controller arranged to selectively one of open or close the reset switch ( S 2) to, respectively, set the preamplifier circuit in one of a normal operating mode or in a reset mode in dependence of an external reset signal, in accordance with a voltage at said output node (Out) or in accordance with a voltage at the output of the feedback circuit, wherein the loop controller is arranged to select a first predefined transfer function ( F 1) for the feedback circuit in response to the preamplifier circuit operating in the normal operating mode and select a second predefined transfer function ( F 2) in response to the preamplifier circuit operating in the reset mode, wherein the first transfer function ( F 1) and the second transfer function ( F 2) differ from each other in amplitude response and/or in frequency response, and wherein the loop controller is arranged to set the gain of the amplifier during the reset mode to a value that is smaller than that applied in the normal operating mode of the preamplifier circuit. an amplifier arranged in a first current path between an input node (In) and an output node (Out) of the preamplifier circuit; a feedback capacitor (Cf) arranged in a second current path between said input node (In) and said output node (Out); a feedback circuit having an adjustable transfer function arranged in a third current path between said input node (In) and said output node (Out); a reset switch ( S 2) arranged in said third current path to enable selectively coupling the output of the feedback circuit to the input of the amplifier and decoupling the output of the feedback circuit from the input of the amplifier; and a loop controller arranged to selectively one of open or close the reset switch ( S 2) to, respectively, set the preamplifier circuit in one of a normal operating mode or in a reset mode in dependence of an external reset signal, in accordance with a voltage at said output node (Out) or in accordance with a voltage at the output of the feedback circuit, wherein the loop controller is arranged to select a first predefined transfer function ( F 1) for the feedback circuit in response to the preamplifier circuit operating in the normal operating mode and select a second predefined transfer function ( F 2) in response to the preamplifier circuit operating in the reset mode, wherein the first transfer function ( F 1) and the second transfer function ( F 2) differ from each other in amplitude response and/or in frequency response, and wherein the loop controller is arranged to set the gain of the amplifier during the reset mode to a value that is smaller than that applied in the normal operating mode of the preamplifier circuit.