A microscope system comprising an imaging system and a microscope, the imaging system comprising: a controller configured to control the imaging system to: capture a first image of a sample comprising a group of cells, the first image being one of a bright field image, a phase difference image, and a differential interference image; calculate a global motion vector, GMV, from the first image and a stored image of the same type as the first image, the GMV being a drift amount of the entire group of cells of the sample in the first image; capture a second image of the sample, the second image being a different type of image than the first image, wherein the microscope comprises a movable stage, wherein the sample is disposed on the movable stage, and wherein the controller is configured to control the microscope to capture the second image by: focusing the microscope, by moving the movable stage by an amount determined based on the calculated GMV, to capture the second image; and after the focusing, causing the microscope to capture the second image; and calculating a motion vector from the second image, the motion vector corresponding to individual movement of each of the cells of the sample in the second image; further focusing the microscope by moving the movable stage by an amount determined based on the calculated motion vector; and re-capturing the first image of the sample using the microscope which has been focused by moving the movable stage by the amount determined based on the calculated GMV and by the amount determined based on the calculated motion vector. a controller configured to control the imaging system to: capture a first image of a sample comprising a group of cells, the first image being one of a bright field image, a phase difference image, and a differential interference image; calculate a global motion vector, GMV, from the first image and a stored image of the same type as the first image, the GMV being a drift amount of the entire group of cells of the sample in the first image; capture a second image of the sample, the second image being a different type of image than the first image, wherein the microscope comprises a movable stage, wherein the sample is disposed on the movable stage, and wherein the controller is configured to control the microscope to capture the second image by: focusing the microscope, by moving the movable stage by an amount determined based on the calculated GMV, to capture the second image; and after the focusing, causing the microscope to capture the second image; and capture a first image of a sample comprising a group of cells, the first image being one of a bright field image, a phase difference image, and a differential interference image; calculate a global motion vector, GMV, from the first image and a stored image of the same type as the first image, the GMV being a drift amount of the entire group of cells of the sample in the first image; capture a second image of the sample, the second image being a different type of image than the first image, wherein the microscope comprises a movable stage, wherein the sample is disposed on the movable stage, and wherein the controller is configured to control the microscope to capture the second image by: focusing the microscope, by moving the movable stage by an amount determined based on the calculated GMV, to capture the second image; and after the focusing, causing the microscope to capture the second image; and focusing the microscope, by moving the movable stage by an amount determined based on the calculated GMV, to capture the second image; and after the focusing, causing the microscope to capture the second image; and calculating a motion vector from the second image, the motion vector corresponding to individual movement of each of the cells of the sample in the second image; further focusing the microscope by moving the movable stage by an amount determined based on the calculated motion vector; and re-capturing the first image of the sample using the microscope which has been focused by moving the movable stage by the amount determined based on the calculated GMV and by the amount determined based on the calculated motion vector.