A system, comprising: a signal input circuit, including a sense amplifier circuit to sense at least one physiological signal from a patient; a memory circuit; a reference value generator circuit coupled to the signal input circuit and the memory circuit, the reference value generator circuit including: a filter circuit to transform one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values; a comparator circuit to transform one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values; and a blending circuit to generate one or more reference values of a physiologic parameter stored in the memory circuit using a combination of the respective one or more baseline statistical values and the respective one or more historical extreme values; a short-term value generator circuit, coupled to the signal input circuit and the memory circuit to transform one or more third signal portions of the received at least one physiological signal during respective one or more third time windows into respective one or more short-term values stored in the memory circuit, the one or more third time windows shorter than the respective first and second time windows; a cardiac condition detector circuit, coupled to the memory circuit or to the reference value generator circuit and short-term value generator circuits to determine a cardiac condition indicator indicative of a heart failure status using the one or more short-term values and the one or more reference values; and an output unit, configured to generate a human-perceptible presentation of an indication of a progression over time of the cardiac condition indicator. a signal input circuit, including a sense amplifier circuit to sense at least one physiological signal from a patient; a memory circuit; a reference value generator circuit coupled to the signal input circuit and the memory circuit, the reference value generator circuit including: a filter circuit to transform one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values; a comparator circuit to transform one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values; and a blending circuit to generate one or more reference values of a physiologic parameter stored in the memory circuit using a combination of the respective one or more baseline statistical values and the respective one or more historical extreme values; a filter circuit to transform one or more first signal portions of the received at least one physiological signal during respective one or more first time windows into respective one or more baseline statistical values; a comparator circuit to transform one or more second signal portions of the received at least one physiological signal during respective one or more second time windows into respective one or more historical extreme values; and a blending circuit to generate one or more reference values of a physiologic parameter stored in the memory circuit using a combination of the respective one or more baseline statistical values and the respective one or more historical extreme values; a short-term value generator circuit, coupled to the signal input circuit and the memory circuit to transform one or more third signal portions of the received at least one physiological signal during respective one or more third time windows into respective one or more short-term values stored in the memory circuit, the one or more third time windows shorter than the respective first and second time windows; a cardiac condition detector circuit, coupled to the memory circuit or to the reference value generator circuit and short-term value generator circuits to determine a cardiac condition indicator indicative of a heart failure status using the one or more short-term values and the one or more reference values; and an output unit, configured to generate a human-perceptible presentation of an indication of a progression over time of the cardiac condition indicator.