A dehumidifier system, comprising a main enclosure that has an air inlet opening and an air outlet opening, comprising a compressor based dehumidification assembly, a rotary wheel based humidification assembly, and an air blower that are arranged in an interior of the main enclosure, wherein the compressor based dehumidification assembly comprises an evaporator, a condenser, a compressor, and a throttle element; wherein the rotary wheel based humidification assembly comprises a dehumidification roller, a regeneration air blower, a heating element and a heat exchanger that includes a first heat exchange passage and a second heat exchange passage that are not in communication with each other; wherein the first heat exchange passage, the regeneration air blower, the heating element, and the dehumidification roller are arranged, in a circulative and communicating configuration, to form a regeneration circulation airflow channel, in which air moves in a closed loop as being driven by the regeneration air blower through the heating element, the dehumidification roller to further pass through the first heat exchange passage of the heat exchanger to return to the regeneration air blower; and wherein the air inlet opening, the second heat exchange passage, the evaporator, the air blower, and the air outlet opening, are arranged, in a circulative and communicating configuration, to form a first airflow channel, in which air moves in an open loop by first moving from the air inlet opening through the second heat exchange passage of the heat exchanger and the evaporator to be driven by the air blower to discharge through the air outlet opening, and wherein a second airflow channel is formed of the air inlet opening, the condenser, the dehumidification roller, the air blower, and the air outlet opening that are arranged to communicate with each other. wherein the compressor based dehumidification assembly comprises an evaporator, a condenser, a compressor, and a throttle element; wherein the rotary wheel based humidification assembly comprises a dehumidification roller, a regeneration air blower, a heating element and a heat exchanger that includes a first heat exchange passage and a second heat exchange passage that are not in communication with each other; wherein the first heat exchange passage, the regeneration air blower, the heating element, and the dehumidification roller are arranged, in a circulative and communicating configuration, to form a regeneration circulation airflow channel, in which air moves in a closed loop as being driven by the regeneration air blower through the heating element, the dehumidification roller to further pass through the first heat exchange passage of the heat exchanger to return to the regeneration air blower; and wherein the air inlet opening, the second heat exchange passage, the evaporator, the air blower, and the air outlet opening, are arranged, in a circulative and communicating configuration, to form a first airflow channel, in which air moves in an open loop by first moving from the air inlet opening through the second heat exchange passage of the heat exchanger and the evaporator to be driven by the air blower to discharge through the air outlet opening, and wherein a second airflow channel is formed of the air inlet opening, the condenser, the dehumidification roller, the air blower, and the air outlet opening that are arranged to communicate with each other.