mhurhangee/ep-ind-claims huggingface dataset:
A flexible endoscope shaft with a shaft body that, viewed in the longitudinal direction of the endoscope shaft, consists of at least two shaft sections (4, 5, 6) with different degrees of flexibility, wherein at least one shaft section (5, 6) consists of at least one spring element, and wherein all spring elements of the shaft sections (5, 6), viewed in the longitudinal direction of the shaft body, are arranged on the proximal side from the outer, distal shaft section and are constructed as reversible, deformable spring rods running in the longitudinal direction of the shaft body, characterized in that viewed in the longitudinal direction of the shaft body from distal to proximal, each of the shaft sections (5, 6) comprising at least one spring rod comprises at least one additional spring rod opposite the previous shaft section comprising at least one spring rod, which shaft section is connected to and has the same substance as the other spring rods of the particular shaft section (5, 6), wherein the at least one additional spring rod is arranged running in the longitudinal direction of the shaft body and at the side of the other spring rods of the particular shaft section (5, 6).
An azide of formula I wherein: V and W represent, independently of one another, a nitrogenous or sulfur-containing heterocycle comprising a copper-complexing heteroatom, said heterocycle being saturated or unsaturated, X and Y bonded to the central nitrogen represent, independently of one another, a spacer group; -(CH 2) 2 -O-(CH 2)-, - (CH 2) -O-(CH 2) 2 -, -(CH 2) -O-(CH 2)-, -(CH 2) 2 -S-(CH 2) -, - (CH 2) -S-(CH 2) 2 -, -(CH 2)-S-(CH 2)-, -(CH 2) 2 -NH-(CH 2)-, -(CH 2)-NH-(CH 2) 2 --(CH 2) -NH-(CH 2) -, ou -(CH 2) m -, wherein m can take the values 1, 2, 3 or 4; Z represents a spacer group -(CH 2) 2 -O-(CH 2) -, -(CH 2) -O-(CH 2) 2 -, -(CH 2) 2 -S-(CH 2)-, -(CH 2) -S-(CH 2) 2 -, -(CH 2) 2 -NH-(CH 2)--(CH 2) -NH-(CH 2) 2 - ou, -(CH 2) n -, wherein n can take the values 1, 2, 3 or 4; F1 and F2 represent, independently of one another, a hydrogen atom, or a tertiary alkyl group having at most 7 carbon atoms, or a functional group which allows the coupling of the azide of formula I to a chemical molecule, to a biomolecule, to a nanoparticle or to a polymer, said functional group being an isocyanate, isothiocyanate, carboxyl, amino, maleimide or thiol group, indirectly grafted onto the heterocycles, it being understood that at least one of F1 and F2 represents a functional group. V and W represent, independently of one another, a nitrogenous or sulfur-containing heterocycle comprising a copper-complexing heteroatom, said heterocycle being saturated or unsaturated, X and Y bonded to the central nitrogen represent, independently of one another, a spacer group; -(CH 2) 2 -O-(CH 2)-, - (CH 2) -O-(CH 2) 2 -, -(CH 2) -O-(CH 2)-, -(CH 2) 2 -S-(CH 2) -, - (CH 2) -S-(CH 2) 2 -, -(CH 2)-S-(CH 2)-, -(CH 2) 2 -NH-(CH 2)-, -(CH 2)-NH-(CH 2) 2 --(CH 2) -NH-(CH 2) -, ou -(CH 2) m -, wherein m can take the values 1, 2, 3 or 4; Z represents a spacer group -(CH 2) 2 -O-(CH 2) -, -(CH 2) -O-(CH 2) 2 -, -(CH 2) 2 -S-(CH 2)-, -(CH 2) -S-(CH 2) 2 -, -(CH 2) 2 -NH-(CH 2)--(CH 2) -NH-(CH 2) 2 - ou, -(CH 2) n -, wherein n can take the values 1, 2, 3 or 4; F1 and F2 represent, independently of one another, a hydrogen atom, or a tertiary alkyl group having at most 7 carbon atoms, or a functional group which allows the coupling of the azide of formula I to a chemical molecule, to a biomolecule, to a nanoparticle or to a polymer, said functional group being an isocyanate, isothiocyanate, carboxyl, amino, maleimide or thiol group, indirectly grafted onto the heterocycles, it being understood that at least one of F1 and F2 represents a functional group.
A method, comprising: a cellular module responding to a cellular communication signal by providing a trigger pulse derived from the data component of the cellular communication signal and directing the trigger pulse along a special hardware path leading from the cellular module to a user module, wherein the special hardware path conducts the trigger pulse in such a way that the trigger pulse is provided to the user module substantially free of any significant random delays; and wherein the user module generates a frequency reference based on at least two trigger pulses based on the identification of a new cellular data frame or time slot or data bit. a cellular module responding to a cellular communication signal by providing a trigger pulse derived from the data component of the cellular communication signal and directing the trigger pulse along a special hardware path leading from the cellular module to a user module, wherein the special hardware path conducts the trigger pulse in such a way that the trigger pulse is provided to the user module substantially free of any significant random delays; and wherein the user module generates a frequency reference based on at least two trigger pulses based on the identification of a new cellular data frame or time slot or data bit.
Tool or wearing part coated with a layer arrangement with layers are largely in an amorphous state for the formation of a coating on a surface of the substrate, wherein the layer arrangement is deposited by means of PVD, and on the surface of the substrate at least one connecting layer is provided, wherein at least a first hard layer is provided having the composition Si a B b Me c N u C v with a,b > 0 and 33 at% > c ≥0, and u,v > 0, and Me being a metal, characterized in, that on the first hard layer a oxygen hard layer as a protective hard layer is provided, having the composition Si a B b C v N u O w, with a,b > 0 und u,v, w > 0.
A refrigerator comprising - a vacuum compartment wherein foodstuffs are placed for being stored without spoiling, - a pump that enables the air inside the vacuum compartment to be evacuated, - at least one ultraviolet lamp that is situated on the vacuum compartment and that provides sterilization, - at least one lid disposed on the vacuum compartment and that allows the foodstuffs to be placed into the vacuum compartment, a control unit that operates the pump during a pump operation time (t p) predetermined by the producer and operates the ultraviolet lamp during a sterilization time (t s) predetermined by the producer according to the pump operation time (t p), characterized by - at least one fresh food compartment wherein foodstuffs to be cooled are placed and in which the vacuum compartment is situated, - the pump operation time (t p) that is predetermined by the producer for each type of food, - the control unit that activates the ultraviolet lamp while the pump is not operated such that the ultraviolet lamp and the pump are never operated simultaneously. - a vacuum compartment wherein foodstuffs are placed for being stored without spoiling, - a pump that enables the air inside the vacuum compartment to be evacuated, - at least one ultraviolet lamp that is situated on the vacuum compartment and that provides sterilization, - at least one lid disposed on the vacuum compartment and that allows the foodstuffs to be placed into the vacuum compartment, a control unit that operates the pump during a pump operation time (t p) predetermined by the producer and operates the ultraviolet lamp during a sterilization time (t s) predetermined by the producer according to the pump operation time (t p), characterized by - at least one fresh food compartment wherein foodstuffs to be cooled are placed and in which the vacuum compartment is situated, - the pump operation time (t p) that is predetermined by the producer for each type of food, - the control unit that activates the ultraviolet lamp while the pump is not operated such that the ultraviolet lamp and the pump are never operated simultaneously.
An instrument for biological analysis, comprising: an excitation source; an optical sensor configured to receive emissions from biological samples in response to the excitation source; an excitation optical system disposed along an excitation optical path; an emission optical system disposed along an emission optical path; a plurality of emission filters which are moveable into and out of the emission optical path; a rotatable filter wheel to which the plurality of emission filters are mounted and configured to move each of the filters into and out of the emission beam path by rotation of the rotatable filter wheel; a position source configured to emit radiation and a corresponding position sensor configured to receive radiation from the position source, the position source and the position sensor together arranged at a radial position with respect to the filter wheel beyond the rotatable filter wheel and configured to produce a position signal indicative of a position of an emission filter of the rotatable filter wheel; a housing enclosing a peripheral portion of the filter wheel, at which portion the emission filters are mounted, the position source and the position sensor being provided to the housing; and radiation shields extending from the housing of the rotatable filter wheel towards the rotatable filter wheel at spaced positions between the position source and the emission beam path so as to block at least some radiation from the position source from reaching the emission beam path. an excitation source; an optical sensor configured to receive emissions from biological samples in response to the excitation source; an excitation optical system disposed along an excitation optical path; an emission optical system disposed along an emission optical path; a plurality of emission filters which are moveable into and out of the emission optical path; a rotatable filter wheel to which the plurality of emission filters are mounted and configured to move each of the filters into and out of the emission beam path by rotation of the rotatable filter wheel; a position source configured to emit radiation and a corresponding position sensor configured to receive radiation from the position source, the position source and the position sensor together arranged at a radial position with respect to the filter wheel beyond the rotatable filter wheel and configured to produce a position signal indicative of a position of an emission filter of the rotatable filter wheel; a housing enclosing a peripheral portion of the filter wheel, at which portion the emission filters are mounted, the position source and the position sensor being provided to the housing; and radiation shields extending from the housing of the rotatable filter wheel towards the rotatable filter wheel at spaced positions between the position source and the emission beam path so as to block at least some radiation from the position source from reaching the emission beam path.
A three-dimensional printing method, comprising: receiving print data defining patterns of a fusing agent to be applied to a layer of powder build material, wherein the patterns are at least partially based on a 3D model of at least one object to be generated; processing the print data to determine regions which are distant from said patterns, including: evaluating an open space around the at least one object to be printed to find vacant volumes in the 3D model data; generating at least one fracture volume within the vacant volumes in the 3D model data, which is spaced apart from the at least one object to be printed, wherein the cross section of the fracture volume is to contain a detailing agent which reduces or prevents fusing of the powder build material when exposed to radiation thereby generating at least one detailing portion of the build material; and modifying the print data to add a further pattern of the detailing agent to be selectively applied to the layer of powder build material, wherein said further pattern comprises the at least one detailing portion of the build material, to generate fracture regions in a processed volume of powder build material. receiving print data defining patterns of a fusing agent to be applied to a layer of powder build material, wherein the patterns are at least partially based on a 3D model of at least one object to be generated; processing the print data to determine regions which are distant from said patterns, including: evaluating an open space around the at least one object to be printed to find vacant volumes in the 3D model data; generating at least one fracture volume within the vacant volumes in the 3D model data, which is spaced apart from the at least one object to be printed, wherein the cross section of the fracture volume is to contain a detailing agent which reduces or prevents fusing of the powder build material when exposed to radiation thereby generating at least one detailing portion of the build material; and modifying the print data to add a further pattern of the detailing agent to be selectively applied to the layer of powder build material, wherein said further pattern comprises the at least one detailing portion of the build material, to generate fracture regions in a processed volume of powder build material. evaluating an open space around the at least one object to be printed to find vacant volumes in the 3D model data; generating at least one fracture volume within the vacant volumes in the 3D model data, which is spaced apart from the at least one object to be printed, wherein the cross section of the fracture volume is to contain a detailing agent which reduces or prevents fusing of the powder build material when exposed to radiation thereby generating at least one detailing portion of the build material; and modifying the print data to add a further pattern of the detailing agent to be selectively applied to the layer of powder build material, wherein said further pattern comprises the at least one detailing portion of the build material, to generate fracture regions in a processed volume of powder build material.
A lysis solution for the extraction of a nucleic acid from a cell or tissue sample, said lysis solution comprising: NaCl at a concentration of greater than 300 mM; a buffer sufficient to maintain the pH of said solution at a pH ranging from pH 6.8 to pH 7.3; a chelating agent; MgCl 2 at a concentration at least 2 mM, but less than 50 mM; and a detergent. NaCl at a concentration of greater than 300 mM; a buffer sufficient to maintain the pH of said solution at a pH ranging from pH 6.8 to pH 7.3; a chelating agent; MgCl 2 at a concentration at least 2 mM, but less than 50 mM; and a detergent.
A system of formwork elements (1, 2) for the manufacture of a ceiling, comprising at least one formwork element which is only suitable for the manufacture of a ceiling as well as at least one formwork element which is suitable for the manufacture of a ceiling and a wall, in which the formwork element only meant for the manufacture of the ceiling has a large surface area in comparison to the formwork element meant for the manufacture of the ceiling and the wall, wherein the formwork element only meant for the manufacture of the ceiling comprises a length of more than 2.70 m, in particular a length of more than four meters, and the formwork element which is suitable for the manufacture of a ceiling and a wall is no longer than 2.70 m, wherein the formwork element having a large surface area is not sufficiently stable for being used for the manufacture of walls having a height of 2.70 m, and the formwork element having a small surface area is sufficiently stable for being used for the manufacture of walls having a height of 2.70 m.
A medical device comprising: an elongate body having opposing proximal and distal end portions with an axially extending center cavity; an internal drive shaft residing in the center cavity, the drive shaft having a proximal end portion with a rotatable spline residing in the proximal end portion of the elongate body; and an extendable member held in the distal end portion of the elongate body, the extendable member in communication with the drive shaft, whereby rotation of the drive shaft causes the extendable member to extend out of the elongate body, characterised by at least one conductor extending along the elongate body, each of the at least one conductor comprising at least one current suppression module, each of the at least one current suppression module comprising the conductor turning back on itself twice in a lengthwise direction to from a conductor configuration of a reverse or backward section in one lengthwise direction and proximately located forward sections that extend in an opposing lengthwise direction. an elongate body having opposing proximal and distal end portions with an axially extending center cavity; an internal drive shaft residing in the center cavity, the drive shaft having a proximal end portion with a rotatable spline residing in the proximal end portion of the elongate body; and an extendable member held in the distal end portion of the elongate body, the extendable member in communication with the drive shaft, whereby rotation of the drive shaft causes the extendable member to extend out of the elongate body, characterised by at least one conductor extending along the elongate body, each of the at least one conductor comprising at least one current suppression module, each of the at least one current suppression module comprising the conductor turning back on itself twice in a lengthwise direction to from a conductor configuration of a reverse or backward section in one lengthwise direction and proximately located forward sections that extend in an opposing lengthwise direction.
Laundry care appliance having an appliance housing, wherein the appliance housing defines an interior of the appliance and has a housing opening, and having a closure panel for closing the housing opening, wherein the laundry care appliance has an adapter with a panel hinge for holding the closure panel on the appliance housing, wherein a gap can be released between the adapter and the appliance housing when opening the closure panel, wherein - the laundry care appliance has a discharge element for discharging liquid, wherein the discharge element is movably arranged on the adapter, - wherein the discharge element can be transferred from a first position, in which the discharge element abuts the adapter, to a second position in which the discharge element is positioned at the gap, - wherein the discharge element is designed in the second position to discharge liquid from the interior of the appliance through the housing opening to an outer region of the laundry care appliance, in order to prevent liquid from being able to penetrate into the gap when a closure panel is open, characterised in that the discharge element has a spring element, wherein the spring element can be actuated by opening the closure panel in order to position the discharge element in the second position at the gap between the adapter and the appliance housing when a closure panel is open. - the laundry care appliance has a discharge element for discharging liquid, wherein the discharge element is movably arranged on the adapter, - wherein the discharge element can be transferred from a first position, in which the discharge element abuts the adapter, to a second position in which the discharge element is positioned at the gap, - wherein the discharge element is designed in the second position to discharge liquid from the interior of the appliance through the housing opening to an outer region of the laundry care appliance, in order to prevent liquid from being able to penetrate into the gap when a closure panel is open,
A polynucleotide construct comprising a promoter operatively linked to a coding sequence for a selectable marker operatively linked to a transcriptional terminator, wherein the promoter is derived from a fungal species selected from a species of the Rhodotorula genus, wherein the promoter derived from a species of the Rhodotorula genus is SEQ ID NO: 51 or 56, wherein the polynucleotide construct provides dominant selection of a transformed fungal cell of the Pucciniomycotina and Ustilaginomycotina subphyla when transformed into a fungal cell of said subphyla.
1-(5-ethyl-2-{[(2 R)-1-methoxypropan-2-yl]oxylphenyl)- N -(2-methylquinoline-5-sulfonyl)cyclopropane-1-carboxamide, or a pharmaceutically acceptable salt thereof.
A compound that inhibits the activity of TGFβ for use in a method of treating, preventing or delaying the onset of bone marrow failure in a patient having Fanconi Anemia, wherein the compound is an antibody specific for TGFβ or TGFβR1.
A method performed by a network device for facilitating handover of a terminal device served by the network device to a target beam and/or network device, the method comprising: transmitting information on configurations for a set of candidate target beams and/or network devices to the terminal device before the handover of the terminal device is triggered; and transmitting a handover command to the terminal device to trigger the handover of the terminal device, wherein the handover command contains an identifier for identifying, from the transmitted information on the configurations for the candidate target beams and/or network devices, the information on the configuration for the target beam and/or network device; characterised in that the method further comprises: stopping Mobile Reference Signal, MRS, transmissions from the serving beam and/or network device and from all the set of candidate target beams and/or network devices except the target beam and/or network device after the handover command is transmitted and requiring only the target beam and/or network device to transmit a MRS for a predetermined time period after the handover command is transmitted, whereby the identifier for identifying the information on the configuration for the target beam and/or network device is derivable at the terminal device from the MRS transmitted via the target beam and/or network device and received by the terminal device. transmitting information on configurations for a set of candidate target beams and/or network devices to the terminal device before the handover of the terminal device is triggered; and transmitting a handover command to the terminal device to trigger the handover of the terminal device, wherein the handover command contains an identifier for identifying, from the transmitted information on the configurations for the candidate target beams and/or network devices, the information on the configuration for the target beam and/or network device; characterised in that the method further comprises: stopping Mobile Reference Signal, MRS, transmissions from the serving beam and/or network device and from all the set of candidate target beams and/or network devices except the target beam and/or network device after the handover command is transmitted and requiring only the target beam and/or network device to transmit a MRS for a predetermined time period after the handover command is transmitted, whereby the identifier for identifying the information on the configuration for the target beam and/or network device is derivable at the terminal device from the MRS transmitted via the target beam and/or network device and received by the terminal device.