A device for determining positioning data for an X-ray image acquisition device on a mobile patient support unit, the device comprising: - a processing unit; and - a status detector; wherein the status detector is configured to acquire geometry data and type data of the mobile patient support unit and of the X-ray image acquisition device on the mobile patient support unit, wherein the geometry data comprises position, angular orientation and alignment data of the components of the X-ray image acquisition device in relation to the mobile patient support unit, wherein the mobile patient unit comprises at least two support devices and the at least two support devices comprise a joint connector; and/or a rotational bearing element, wherein the rotational bearing element is connected to the mobile patient support unit, wherein at least one of the at least two support devices is movably attached to the mobile patient support unit, wherein the X-ray image acquisition device comprises an X-ray tube and an X-ray detector, and wherein at least one of the at least two support devices is attached to the X-ray tube and the at least one of the remaining support devices is attached to the X-ray detector; wherein the status detector is configured to transmit a status signal comprising the geometry data and the type data; wherein the processing unit is configured to receive the status signal and data about region of interest position on the patient; and wherein, based on the status signal and the region of interest position, the processing unit is configured to determine corrected spatial position, angular orientation and alignment data for the components of the X-ray image acquisition device in relation to the mobile patient support unit, and to provide an image acquisition protocol for the X-ray image acquisition device. - a processing unit; and - a status detector; wherein the status detector is configured to acquire geometry data and type data of the mobile patient support unit and of the X-ray image acquisition device on the mobile patient support unit, wherein the geometry data comprises position, angular orientation and alignment data of the components of the X-ray image acquisition device in relation to the mobile patient support unit, wherein the mobile patient unit comprises at least two support devices and the at least two support devices comprise a joint connector; and/or a rotational bearing element, wherein the rotational bearing element is connected to the mobile patient support unit, wherein at least one of the at least two support devices is movably attached to the mobile patient support unit, wherein the X-ray image acquisition device comprises an X-ray tube and an X-ray detector, and wherein at least one of the at least two support devices is attached to the X-ray tube and the at least one of the remaining support devices is attached to the X-ray detector; wherein the status detector is configured to transmit a status signal comprising the geometry data and the type data; wherein the processing unit is configured to receive the status signal and data about region of interest position on the patient; and wherein, based on the status signal and the region of interest position, the processing unit is configured to determine corrected spatial position, angular orientation and alignment data for the components of the X-ray image acquisition device in relation to the mobile patient support unit, and to provide an image acquisition protocol for the X-ray image acquisition device. wherein the status detector is configured to acquire geometry data and type data of the mobile patient support unit and of the X-ray image acquisition device on the mobile patient support unit, wherein the geometry data comprises position, angular orientation and alignment data of the components of the X-ray image acquisition device in relation to the mobile patient support unit, wherein the mobile patient unit comprises at least two support devices and the at least two support devices comprise a joint connector; and/or a rotational bearing element, wherein the rotational bearing element is connected to the mobile patient support unit, wherein at least one of the at least two support devices is movably attached to the mobile patient support unit, wherein the X-ray image acquisition device comprises an X-ray tube and an X-ray detector, and wherein at least one of the at least two support devices is attached to the X-ray tube and the at least one of the remaining support devices is attached to the X-ray detector; wherein the status detector is configured to transmit a status signal comprising the geometry data and the type data; wherein the processing unit is configured to receive the status signal and data about region of interest position on the patient; and wherein, based on the status signal and the region of interest position, the processing unit is configured to determine corrected spatial position, angular orientation and alignment data for the components of the X-ray image acquisition device in relation to the mobile patient support unit, and to provide an image acquisition protocol for the X-ray image acquisition device.