A method of in-line inspection of integrity of a pipeline the method comprising: accessing, via a processor, data from a tool that was run in a pipeline that indicates one or more features at different locations in the pipeline; identifying, via the processor, a first prospective metal loss cluster related to at least a first feature of the pipeline and a second prospective metal loss cluster related to at least a second feature of the pipeline, the clusters being clusters of interacting boxes clustered, via the processor, based on the application of clustering rules, the boxes having attributes which correspond to attributes of features of the pipeline and are determined to interact when a distance between the boxes is less than a multiple of the pipe wall thickness or less than a multiple of the length of the shortest box; characterized by calculating, via the processor, an effective area (42, 76, 78, 80) using an interaction technique, wherein the interaction technique comprises a Length Adaptive Pressure Assessment (LAPA) technique, a Remaining Strength (RStreng) technique, or any combination thereof, wherein the effective area (42, 76, 78, 80) corresponds to a lower calculated burst pressure than surrounding areas of the pipeline, wherein the interaction technique is used to determine if the first prospective cluster and the second prospective cluster both fall within the effective area; combining, via the processor, the first and the second prospective clusters (66, 68) when the effective area (42, 76, 78, 80) includes the first and the second prospective clusters (66, 68) to form a resultant cluster; and generating, via the processor, an indication of an attribute of the resultant cluster comprising at least one of a minimum burst pressure and a pipeline location. accessing, via a processor, data from a tool that was run in a pipeline that indicates one or more features at different locations in the pipeline; identifying, via the processor, a first prospective metal loss cluster related to at least a first feature of the pipeline and a second prospective metal loss cluster related to at least a second feature of the pipeline, the clusters being clusters of interacting boxes clustered, via the processor, based on the application of clustering rules, the boxes having attributes which correspond to attributes of features of the pipeline and are determined to interact when a distance between the boxes is less than a multiple of the pipe wall thickness or less than a multiple of the length of the shortest box; characterized by calculating, via the processor, an effective area (42, 76, 78, 80) using an interaction technique, wherein the interaction technique comprises a Length Adaptive Pressure Assessment (LAPA) technique, a Remaining Strength (RStreng) technique, or any combination thereof, wherein the effective area (42, 76, 78, 80) corresponds to a lower calculated burst pressure than surrounding areas of the pipeline, wherein the interaction technique is used to determine if the first prospective cluster and the second prospective cluster both fall within the effective area; combining, via the processor, the first and the second prospective clusters (66, 68) when the effective area (42, 76, 78, 80) includes the first and the second prospective clusters (66, 68) to form a resultant cluster; and generating, via the processor, an indication of an attribute of the resultant cluster comprising at least one of a minimum burst pressure and a pipeline location.