mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method of generating a multipotent induced neural stem cell, the method comprising: a) introducing an exogenous Sox2 polypeptide into a somatic cell, to generate an exogenous Sox2-modified somatic cell that comprises exogenous Sox polypeptide, wherein said Sox2 is introduced as the single exogenous induction factor, or said introducing does not comprise introduction of exogenous Oct-3/4, exogenous c-myc, exogenous Klf4, exogenous Nanog, or exogenous Lin28 into the somatic cell, wherein said introducing comprises: i) genetically modifying the somatic cell with a nucleic acid comprising a nucleotide sequence encoding a Sox2 polypeptide; or ii) introducing an exogenous Sox2 polypeptide into the somatic cell; and b) culturing the exogenous Sox2-modified somatic cell on a protein-coated solid substrate, wherein said solid substrate comprises a material other than a plastic; wherein said introducing and said culturing results in generation of a multipotent induced neural stem cell (iNSC). a) introducing an exogenous Sox2 polypeptide into a somatic cell, to generate an exogenous Sox2-modified somatic cell that comprises exogenous Sox polypeptide, wherein said Sox2 is introduced as the single exogenous induction factor, or said introducing does not comprise introduction of exogenous Oct-3/4, exogenous c-myc, exogenous Klf4, exogenous Nanog, or exogenous Lin28 into the somatic cell, wherein said introducing comprises: i) genetically modifying the somatic cell with a nucleic acid comprising a nucleotide sequence encoding a Sox2 polypeptide; or ii) introducing an exogenous Sox2 polypeptide into the somatic cell; and i) genetically modifying the somatic cell with a nucleic acid comprising a nucleotide sequence encoding a Sox2 polypeptide; or ii) introducing an exogenous Sox2 polypeptide into the somatic cell; and b) culturing the exogenous Sox2-modified somatic cell on a protein-coated solid substrate, wherein said solid substrate comprises a material other than a plastic;
A formulation comprising fenfluramine or a pharmaceutically acceptable salt thereof for use in the treatment of Dravet syndrome, wherein said treatment comprises administration of fenfluramine as a monotherapy.
Hemodialysis device for performing a single-needle hemodialysis treatment, comprising a dialysate circuit, a blood circuit and a dialyzer between the dialysate circuit and the blood circuit, wherein the dialyzer has a dialysate chamber and a blood chamber, wherein the dialysate circuit comprises: a dialysate source which supplies a dialysis liquid, a feed pump between the dialysate source and the dialyzer for feeding the dialysis liquid form the dialysate source to a dialysate chamber of the dialyzer, and a waste pump downstream of the dialysate chamber of the dialyzer, wherein the dialysate chamber and the waste pump are in fluid connection through an outflow line, wherein the blood circuit comprises: a single vessel connection line which is adjoined by a line branching from which a suction line leads to an inlet of the dialyzer blood chamber and a return line leads to an outlet of the dialyzer blood chamber, a blood pump along the suction line, and a line valve along the return line, wherein a separate oscillation volume branched from the outflow line is arranged in the dialysate circuit and fluidically between the feed pump and the waste pump, and wherein a device control is provided which coordinates the switching of the line valve and the oscillation of the oscillation volume. a dialysate source which supplies a dialysis liquid, a feed pump between the dialysate source and the dialyzer for feeding the dialysis liquid form the dialysate source to a dialysate chamber of the dialyzer, and a waste pump downstream of the dialysate chamber of the dialyzer, wherein the dialysate chamber and the waste pump are in fluid connection through an outflow line, a single vessel connection line which is adjoined by a line branching from which a suction line leads to an inlet of the dialyzer blood chamber and a return line leads to an outlet of the dialyzer blood chamber, a blood pump along the suction line, and a line valve along the return line,
Housing, comprising three housing parts for a switchgear cabinet, having three wall elements arranged in a U-shape to one another, connected to one another as one part in housing corner regions by means of bending edges, wherein each housing part comprises a wall element comprising in turn on at least one of its edges an integrally profiled frame profile, wherein the frame profile has, on its housing inner face, profile sides (33, 34) with attachment mounts (35, 36), wherein the frame profile comprises two first profile sides (31, 33) which are oriented parallel to the wall element and two second profile sides (31, 34) which in each case stand perpendicular to the wall element, characterized in that the first and the second profile sides (31, 33, 34) comprise in each case a series of attachment mounts (35, 36), and the frame profile forms a closed profile section, connected to which, indirectly or directly, is an open profile section, wherein two of the profile sides (31, 33, 34) are arranged at right angles to one another, and in each case delimit the closed profile section on the inner face, and two more of the profile sides (31, 33, 34) are arranged at right angles to one another, and delimit the open profile section on the inner face, wherein the wall element is formed onto the frame profile by way of a transition section, and the transition section merges into an edge, of which one contact section is edged and oriented at right angles to the wall element, wherein the contact section, together with a further contact section and an attachment mount, forms a V-shaped rainwater gully, wherein the rainwater gullies of the frame profiles merge into one another in the abutment regions of the frame profiles; and wherein the vertical wall elements delimiting the open U-side are connected to one another by means of a switchgear cabinet base.
A method for degumming an oil comprising: a. mixing oil containing phospholipids with an acid to form a pre-treated oil mixture; b. passing the pre-treated oil mixture through a local constriction of a hydrodynamic cavitation device to form a field of hydrodynamic cavitation bubbles in the pre-treated oil mixture for reacting the phospholipids in the oil with the acid, the pre-treated oil mixture being subjected to the field of hydrodynamic cavitation bubbles for residence time of less than 10×10 -5 seconds; wherein the reacted phospholipids remain in the oil of the pre-treated oil mixture such that the reacted phospholipids are not transferred to a water phase portion of the pre-treated oil mixture; c. collapsing the hydrodynamic cavitation bubbles to form a processed oil mixture; and d. directing the processed oil mixture to a mass transfer, non-cavitational reactor, the processed oil mixture being held in the mass transfer, non-cavitational reactor for at least 0.4 seconds, the reacted phospholipids being transferred from an oil phase in the processed oil mixture to a water phase in the processed oil mixture, e. separating the water phase from the oil phase in the processed oil mixture to form a purified oil, wherein the purified oil contains less than 2 ppm of phosphorous or has a phosphorous content of at least 98.5 percent by weight less than the oil used in step a) to form the pre-treated oil mixture. a. mixing oil containing phospholipids with an acid to form a pre-treated oil mixture; b. passing the pre-treated oil mixture through a local constriction of a hydrodynamic cavitation device to form a field of hydrodynamic cavitation bubbles in the pre-treated oil mixture for reacting the phospholipids in the oil with the acid, the pre-treated oil mixture being subjected to the field of hydrodynamic cavitation bubbles for residence time of less than 10×10 -5 seconds; wherein the reacted phospholipids remain in the oil of the pre-treated oil mixture such that the reacted phospholipids are not transferred to a water phase portion of the pre-treated oil mixture; c. collapsing the hydrodynamic cavitation bubbles to form a processed oil mixture; and d. directing the processed oil mixture to a mass transfer, non-cavitational reactor, the processed oil mixture being held in the mass transfer, non-cavitational reactor for at least 0.4 seconds, the reacted phospholipids being transferred from an oil phase in the processed oil mixture to a water phase in the processed oil mixture, e. separating the water phase from the oil phase in the processed oil mixture to form a purified oil, wherein the purified oil contains less than 2 ppm of phosphorous or has a phosphorous content of at least 98.5 percent by weight less than the oil used in step a) to form the pre-treated oil mixture.
A shape-memory alloy, comprising a base alloy formed from manganese, silicon, chromium and nickel and a remaining mass fraction of at least 50 % by weight iron, wherein the shape-memory alloy contains 17 to 20 % by weight manganese 4 to 6 % by weight silicon 8 to 10 % by weight chromium 4 to 7 % by weight nickel 0.2 to 1.0 % by weight vanadium 0.2 to 1.0 % by weight carbon and/or 0.2 to 1.0 % by weight nitrogen, characterised in that the shape-memory alloy contains precipitated vanadium carbide sediments and/or vanadium nitride sediments, which are present in the form of a precipitate formed from nanoparticles dimensioned within the nanometre range, finely distributed in the shape-memory alloy. 17 to 20 % by weight manganese 4 to 6 % by weight silicon 8 to 10 % by weight chromium 4 to 7 % by weight nickel 0.2 to 1.0 % by weight vanadium 0.2 to 1.0 % by weight carbon and/or 0.2 to 1.0 % by weight nitrogen,
A method of controlling a mobile IP with which a mobile terminal and a partner terminal communicates via a home agent which manages a foreign address of the mobile terminal, including: a radio connection establishment step in which the mobile terminal establishes a radio connection at a visited location and a foreign address is assigned to the mobile terminal by a foreign agent which relays the communication between the mobile terminal and the home agent; a communication band detection step in which the foreign agent detects a value of the communication band of the established radio connection; a foreign address notification step in which the foreign agent notifies the home agent of the value of the detected communication band and the foreign address; and a transmission rate control step in which the home agent controls a packet transmission rate based on the notified value of the communication band when the home agent forwards a packet received from the partner terminal to the notified foreign address. a radio connection establishment step in which the mobile terminal establishes a radio connection at a visited location and a foreign address is assigned to the mobile terminal by a foreign agent which relays the communication between the mobile terminal and the home agent; a communication band detection step in which the foreign agent detects a value of the communication band of the established radio connection; a foreign address notification step in which the foreign agent notifies the home agent of the value of the detected communication band and the foreign address; and a transmission rate control step in which the home agent controls a packet transmission rate based on the notified value of the communication band when the home agent forwards a packet received from the partner terminal to the notified foreign address.
A new and distinct variety of higher Basidiomycetes mushroom Cyathus striatus HAI-1302, deposited under The Budapest Treaty with the Centralbureau voor Schimmelcultures under Accession No. CBS 126585 (hereinafter Cyathus striatus CBS 126585).
Suction handpiece for a dental treatment unit comprising a negative pressure connection which is adapted to be connected with a negative pressure source of the treatment unit, a saliva connection which is adapted to be connected with a saliva suction cannula, an atomized spray connection which is adapted to be connected with an atomized spray suction cannula, a branched flow path which connects the negative pressure connection not only with the saliva connection but also with the atomized spray connection, wherein the flow path includes branching section on which a negative pressure channel ending on the negative pressure connection divides into a saliva channel ending on the saliva connection, and an atomized spray channel ending on the atomized spray connection, and wherein the atomized spray channel at its narrowest point (d 4) has a first cross sectional area A1 which is at least twice as large as a second cross sectional area A2 at the narrowest point (d 5) of the saliva channel. a negative pressure connection which is adapted to be connected with a negative pressure source of the treatment unit, a saliva connection which is adapted to be connected with a saliva suction cannula, an atomized spray connection which is adapted to be connected with an atomized spray suction cannula, a branched flow path which connects the negative pressure connection not only with the saliva connection but also with the atomized spray connection, wherein the flow path includes branching section on which a negative pressure channel ending on the negative pressure connection divides into a saliva channel ending on the saliva connection, and an atomized spray channel ending on the atomized spray connection, and wherein the atomized spray channel at its narrowest point (d 4) has a first cross sectional area A1 which is at least twice as large as a second cross sectional area A2 at the narrowest point (d 5) of the saliva channel. the flow path includes branching section on which a negative pressure channel ending on the negative pressure connection divides into a saliva channel ending on the saliva connection, and an atomized spray channel ending on the atomized spray connection, and wherein the atomized spray channel at its narrowest point (d 4) has a first cross sectional area A1 which is at least twice as large as a second cross sectional area A2 at the narrowest point (d 5) of the saliva channel.
An epoxy resin, comprising an epoxy compound, the epoxy compound comprising two or more structures represented by the following Formula and at least one divalent biphenyl group: wherein, in Formula, each of R 1 to R 4 independently represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, and wherein the epoxy compound comprises at least one selected from the group consisting of a structure represented by the following Formula (II-A) and a structure represented by the following Formula (II-B): wherein, in Formula (II-A) and Formula (II-B), each of R 1 to R 4 independently represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, each of R 5 and R 6 independently represents an alkyl group having from 1 to 8 carbon atoms, each of n and m independently represents an integer from 0 to 4, and each X independently represents -O- or -NH-. wherein, in Formula, each of R 1 to R 4 independently represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, and wherein the epoxy compound comprises at least one selected from the group consisting of a structure represented by the following Formula (II-A) and a structure represented by the following Formula (II-B): wherein, in Formula (II-A) and Formula (II-B), each of R 1 to R 4 independently represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, each of R 5 and R 6 independently represents an alkyl group having from 1 to 8 carbon atoms, each of n and m independently represents an integer from 0 to 4, and each X independently represents -O- or -NH-.
A fuel injection control device for a fuel supply system that injects fuel to an inside of a cylinder as a part of a target engine for performing fuel combustion, an intake passage of the engine or an exhaust passage of the engine with a predetermined injector, characterized by: a fuel pressure sensing means provided in a fuel inlet of the injector or inside the injector for sequentially sensing fuel pressure fluctuating with the injection of the injector; an injection centroid detecting means (S72, S82) for detecting an injection centroid as a geometric centroid of a diagram as a profile of a transition of an injection rate at a present time based on injection timing and a maximum injection rate detected from a transition of the fuel pressure sequentially sensed by the fuel pressure sensing means, the injection rate being equivalent to a fuel quantity injected from the injector per unit time; and an injection varying means for varying an injection command to the injector or an injection condition of the injector based on the injection centroid detected by the injection centroid detecting means (S72, S82) and an injection centroid of a predetermined basic diagram such that a relative positional relationship between the injection centroid of the diagram as the actual profile of the injection rate transition and the injection centroid of the basic diagram becomes a predetermined relationship where timings of the injection centroids of the both diagrams coincide with each other, wherein the basic diagram includes one of a triangle, a trapezoid and a rectangle or a diagram made by combining multiple pieces of at least one kind of the triangle, the trapezoid and the rectangle. a fuel pressure sensing means provided in a fuel inlet of the injector or inside the injector for sequentially sensing fuel pressure fluctuating with the injection of the injector; an injection centroid detecting means (S72, S82) for detecting an injection centroid as a geometric centroid of a diagram as a profile of a transition of an injection rate at a present time based on injection timing and a maximum injection rate detected from a transition of the fuel pressure sequentially sensed by the fuel pressure sensing means, the injection rate being equivalent to a fuel quantity injected from the injector per unit time; and an injection varying means for varying an injection command to the injector or an injection condition of the injector based on the injection centroid detected by the injection centroid detecting means (S72, S82) and an injection centroid of a predetermined basic diagram such that a relative positional relationship between the injection centroid of the diagram as the actual profile of the injection rate transition and the injection centroid of the basic diagram becomes a predetermined relationship where timings of the injection centroids of the both diagrams coincide with each other, wherein the basic diagram includes one of a triangle, a trapezoid and a rectangle or a diagram made by combining multiple pieces of at least one kind of the triangle, the trapezoid and the rectangle.
A method of improving heat-sealability of a polyester, characterized in that a polyester coating layer containing polylactide on a fibrous substrate comprising paper, paperboard or cardboard is subjected to electron beam radiation, thereby decreasing the melt viscosity of the coating.
A bearing steel composition consisting of: (a) from 0.1 to 0.2 wt.% C, (b) from 3.25 to 4.25 wt.% Cr, (c) from 9.5 to 11.5 wt.% Mo, (d) from 5.75 to 6.75 wt.% W, (e) from 1.5 to 2.5 wt.% V, (f) from 2.5 to 3.5 wt.% Ni, (g) optionally one or more of the following elements from 0 - 1 wt.% Mn, from 0 - 1 wt.% N, from 0 - 1 wt.% Si, from 0 - 1 wt.% Co, from 0 - 1 wt.% Al, from 0 - 0.1 wt.% S, from 0 - 0.1 wt.% P from 0 - 0.1 wt.% O, and (h) the balance iron, together with unavoidable impurities, wherein the unavoidable impurities, in total, do not exceed 0.5 wt.% of the composition. (a) from 0.1 to 0.2 wt.% C, (b) from 3.25 to 4.25 wt.% Cr, (c) from 9.5 to 11.5 wt.% Mo, (d) from 5.75 to 6.75 wt.% W, (e) from 1.5 to 2.5 wt.% V, (f) from 2.5 to 3.5 wt.% Ni, (g) optionally one or more of the following elements from 0 - 1 wt.% Mn, from 0 - 1 wt.% N, from 0 - 1 wt.% Si, from 0 - 1 wt.% Co, from 0 - 1 wt.% Al, from 0 - 0.1 wt.% S, from 0 - 0.1 wt.% P from 0 - 0.1 wt.% O, and (h) the balance iron, together with unavoidable impurities, wherein the unavoidable impurities, in total, do not exceed 0.5 wt.% of the composition.
A planar layered component arrangement for temperature-compensated optical detection of an oxygen content of a fluid, the planar layered component arrangement encompassing: - a luminophore-containing reaction layered body whose luminophore is excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength, the excited emission behavior of the luminophore being dependent on an oxygen partial pressure in a fluid contacting the luminophore; and - a temperature-detection layered body emitting an infrared radiation, wherein the reaction layered body and the temperature-detection layered body are embodied separately from one another, wherein the temperature-detection layered body is devoid of luminophore, wherein the reaction layered body has a fluid-contact side on which the reaction layered body is configured for contact with the fluid, and opposite from the fluid-contact side, and wherein the temperature-detection layered body has a detection side, wherein the detection side (62d, 64d) are configured for interaction with radiation detectors (86, 90), wherein the reaction layered body and the temperature-detection layered body each have a fluid-contact side (62c, 64c) on which the respective layered body (62, 64) is configured for contact with the fluid, and a detection side (62d, 64d), wherein the respective detection side (62d, 64d) is opposite from the fluid-contact side (62c, 64c) of the same layered body (62, 64), wherein the reaction layered body and the temperature-detection layered body are arranged in a spatially separated manner, such that only the reaction layered body can be irradiated by the first electromagnetic radiation and that infrared radiation only starting from the temperature-detection layered body can be detected, wherein the fluid-contact sides face in the same direction and the reaction layered body and the temperature-detection layered body are arranged laterally with respect to one another. - a luminophore-containing reaction layered body whose luminophore is excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength, the excited emission behavior of the luminophore being dependent on an oxygen partial pressure in a fluid contacting the luminophore; and - a temperature-detection layered body emitting an infrared radiation, wherein the reaction layered body and the temperature-detection layered body are embodied separately from one another, wherein the temperature-detection layered body is devoid of luminophore, wherein the reaction layered body has a fluid-contact side on which the reaction layered body is configured for contact with the fluid, and opposite from the fluid-contact side, and wherein the temperature-detection layered body has a detection side, wherein the detection side (62d, 64d) are configured for interaction with radiation detectors (86, 90),