An excisional device, comprising: a handle portion comprising a distal end and a proximal end; a cutting assembly coupled to the distal end of the handle portion and configured to rotate, core and part-off pieces of tissue, the cutting assembly comprising a single hypo tube having cuts therein that form a first articulable beak and a second articulable beak, each of the first and second articulable beaks comprising a first tendon forming one outermost open edge thereof and a second tendon forming another outermost edge thereof; a manual part-off button coupled to the first and second articulable beaks; a proximal sheath, coupled to the cutting assembly and configured to both rotate and move in axial proximal and distal directions; a distal sheath fitted at least partially over the proximal sheath and configured to move in the axial proximal and distal directions independently of the proximal sheath; a tissue storing magazine coupled to the proximal end of the handle portion and configured to receive and store the parted-off pieces of tissue, and a transport assembly disposed at least partially within the handle portion and configured to receive the parted-off pieces of tissue and transport them toward the tissue storing magazine, wherein differential axial movement of the proximal sheath relative to the distal sheath opens and closes the first and second articulable beaks by pushing and pulling on, respectively, the first and second tendons, wherein the manual part-off button is configured to enable an operator of the excisional device to open or close the first and second beaks with or without rotation of the proximal sheath, and wherein the cutting assembly is configured, during a single insertion thereof into tissue, to rotate, core and part-off pieces of tissue while the transport assembly transports the parted-off pieces of tissue and while the tissue storing magazine receives and stores the transported pieces of tissue. a handle portion comprising a distal end and a proximal end; a cutting assembly coupled to the distal end of the handle portion and configured to rotate, core and part-off pieces of tissue, the cutting assembly comprising a single hypo tube having cuts therein that form a first articulable beak and a second articulable beak, each of the first and second articulable beaks comprising a first tendon forming one outermost open edge thereof and a second tendon forming another outermost edge thereof; a manual part-off button coupled to the first and second articulable beaks; a proximal sheath, coupled to the cutting assembly and configured to both rotate and move in axial proximal and distal directions; a distal sheath fitted at least partially over the proximal sheath and configured to move in the axial proximal and distal directions independently of the proximal sheath; a tissue storing magazine coupled to the proximal end of the handle portion and configured to receive and store the parted-off pieces of tissue, and a transport assembly disposed at least partially within the handle portion and configured to receive the parted-off pieces of tissue and transport them toward the tissue storing magazine, wherein differential axial movement of the proximal sheath relative to the distal sheath opens and closes the first and second articulable beaks by pushing and pulling on, respectively, the first and second tendons, wherein the manual part-off button is configured to enable an operator of the excisional device to open or close the first and second beaks with or without rotation of the proximal sheath, and wherein the cutting assembly is configured, during a single insertion thereof into tissue, to rotate, core and part-off pieces of tissue while the transport assembly transports the parted-off pieces of tissue and while the tissue storing magazine receives and stores the transported pieces of tissue.