An implant alignment and resection guide system (10, 410, 510, 610, 710, 810), comprising: a target base configured to couple to the exterior of a patient (110, 210, 310) in a first location that is in substantial alignment with an alignment axis associated with an anatomical structure of interest of a patient (110, 210, 310); a target member (118, 218) configured to couple to the target base, comprising a visual indication of the location of the alignment axis; a laser device (432, 532, 632, 732, 832) configured to project a laser light line (338, 438, 538, 638, 738, 838); and an implant guide (586, 638, 738) configured to couple to the patient (110, 210, 310) proximate to the anatomical structure of interest (110, 210, 310) and couple with the laser device (432, 532, 632, 732, 832), wherein the implant guide (430, 586, 638, 738) comprises a guide block (430, 530, 630, 830) with a slot (431, 531, 631, 831) and a resection guide comprising at least one resection guide aperture (435, 535, 635, 835) configured to guide the resection of at least one portion of the anatomical structure of interest (110, 210, 310), wherein the laser device (432, 532, 632, 732, 832) comprises a tang (433, 533, 633, 733, 833) configured to removably mate within the slot (431, 531, 631, 831) of the guide block (430, 530, 630, 830) to removably couple the laser device (432, 532, 632, 732, 832) and the guide block (430, 530, 630, 830) together, and wherein the implant guide (586, 638, 738) is configured such that when the tang of the laser device is mated within the slot and the laser light line (338, 438, 538, 638, 738, 838) is substantially aligned with the visual indication of the target member (118, 218), resection of the anatomical structure of interest (110, 210, 310) via the resection guide facilitates implantation of an implant in the resected anatomical structure of interest (110, 210, 310) such that the implant is in alignment with the alignment axis. a target base configured to couple to the exterior of a patient (110, 210, 310) in a first location that is in substantial alignment with an alignment axis associated with an anatomical structure of interest of a patient (110, 210, 310); a target member (118, 218) configured to couple to the target base, comprising a visual indication of the location of the alignment axis; a laser device (432, 532, 632, 732, 832) configured to project a laser light line (338, 438, 538, 638, 738, 838); and an implant guide (586, 638, 738) configured to couple to the patient (110, 210, 310) proximate to the anatomical structure of interest (110, 210, 310) and couple with the laser device (432, 532, 632, 732, 832), wherein the implant guide (430, 586, 638, 738) comprises a guide block (430, 530, 630, 830) with a slot (431, 531, 631, 831) and a resection guide comprising at least one resection guide aperture (435, 535, 635, 835) configured to guide the resection of at least one portion of the anatomical structure of interest (110, 210, 310), wherein the laser device (432, 532, 632, 732, 832) comprises a tang (433, 533, 633, 733, 833) configured to removably mate within the slot (431, 531, 631, 831) of the guide block (430, 530, 630, 830) to removably couple the laser device (432, 532, 632, 732, 832) and the guide block (430, 530, 630, 830) together, and wherein the implant guide (586, 638, 738) is configured such that when the tang of the laser device is mated within the slot and the laser light line (338, 438, 538, 638, 738, 838) is substantially aligned with the visual indication of the target member (118, 218), resection of the anatomical structure of interest (110, 210, 310) via the resection guide facilitates implantation of an implant in the resected anatomical structure of interest (110, 210, 310) such that the implant is in alignment with the alignment axis.