A compound having Formula, or a stereoisomer, a geometric isomer, a tautomer, an N -oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, wherein k is 0, 1, 2 or 3; m is 0, 1, 2, 3 or 4; n is 1, 2, 3 or 4; each X is independently CH; each Y is independently CH; each R 1 and R 3 is independently H, D, F, Cl, Br, I, -CN, -NO 2, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylthio, C 1-6 alkenylthio, C 6-10 aryl, 5- to 12-membered heteroaryl or 3- to 12-membered heterocyclyl; each R 2 is independently H, D, F, Cl, Br, I, -CN, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy or C 6-10 aryl; or two adjacent R 2, together with the carbon atoms to which they are attached, form a substituted or unsubstituted 5- to 7-membered carbocyclic ring, 5- to 7-membered heterocyclic ring, benzene ring or 5- to 6-membered heteroaromatic ring; R 4 is H, D, C 1-6 alkyl or C 1-6 haloalkyl; each of R 5 and R 6 is independently H, D, F, Cl, Br, I, -CN, -NO 2, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3- to 12-memerbered heterocyclyl or C 3-8 cycloalkyl; or R 5 and R 6 together with the carbon atom to which they are attached, independently form a substituted or unsubstituted 3- to 8-membered carbocyclic ring or 3- to 8-membered heterocyclic ring; each of R 7 and R 8 is independently H; R 10 is 3- to 12-membered heterocyclyl, C 3-8 cycloalkyl, C 6-10 aryl or 5- to 12-membered heteroaryl, and wherein optionally each of 3- to 12-membered heterocyclyl, C 3-8 cycloalkyl, C 6-10 aryl and 5- to 12-membered heteroaryl is independently substituted with 1, 2, 3 or 4 substitutents independently selected from H, D, F, Cl, Br, I, -CN, oxo (=O), C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, (C 6-10 aryl)-(C 1-6 alkyl)- or (5- to 12-membered heteroaryl)-(C 1-6 alkyl)-. k is 0, 1, 2 or 3; m is 0, 1, 2, 3 or 4; n is 1, 2, 3 or 4; each X is independently CH; each Y is independently CH; each R 1 and R 3 is independently H, D, F, Cl, Br, I, -CN, -NO 2, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylthio, C 1-6 alkenylthio, C 6-10 aryl, 5- to 12-membered heteroaryl or 3- to 12-membered heterocyclyl; each R 2 is independently H, D, F, Cl, Br, I, -CN, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy or C 6-10 aryl; or two adjacent R 2, together with the carbon atoms to which they are attached, form a substituted or unsubstituted 5- to 7-membered carbocyclic ring, 5- to 7-membered heterocyclic ring, benzene ring or 5- to 6-membered heteroaromatic ring; R 4 is H, D, C 1-6 alkyl or C 1-6 haloalkyl; each of R 5 and R 6 is independently H, D, F, Cl, Br, I, -CN, -NO 2, -OH, -NH 2, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3- to 12-memerbered heterocyclyl or C 3-8 cycloalkyl; or R 5 and R 6 together with the carbon atom to which they are attached, independently form a substituted or unsubstituted 3- to 8-membered carbocyclic ring or 3- to 8-membered heterocyclic ring; each of R 7 and R 8 is independently H; R 10 is 3- to 12-membered heterocyclyl, C 3-8 cycloalkyl, C 6-10 aryl or 5- to 12-membered heteroaryl, and wherein optionally each of 3- to 12-membered heterocyclyl, C 3-8 cycloalkyl, C 6-10 aryl and 5- to 12-membered heteroaryl is independently substituted with 1, 2, 3 or 4 substitutents independently selected from H, D, F, Cl, Br, I, -CN, oxo (=O), C 1-6 alkyl, C 3-8 cycloalkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, (C 6-10 aryl)-(C 1-6 alkyl)- or (5- to 12-membered heteroaryl)-(C 1-6 alkyl)-.