A compound of general formula or a pharmaceutically acceptable salt thereof, wherein: A is H, CN, Cl, F, cyclopropyl, (1-4 C) alkyl or OMe; A 1 is H, Cl, Br, F, cyclopropyl, (1-4 C) alkyl or OMe; R 1 is -W-L 1 -hetAr 1; W is -CONR 3a - or -NR 3b CO-; R 3a and R 3b are each H or methyl; L 1 is a -(CR a R b) n - or n is 0 or 2; R a and R b are independently H, F, methyl, or cyclopropyl, or R a and R b together with the carbon to which they are attached form a cyclopropyl ring; hetAr 1 is heteroaryl ring selected from the structures: wherein m is 0 or 1 and each of said heteroaryl rings is optionally substituted with one or more R c substituents; or hetAr 1 is a 5,6-bicyclic heteroaryl having two ring heteroatoms independently selected from N, O and S, wherein at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from -O(1-6Calkyl alkyl, halogen and CF 3; or hetAr 1 is 2-oxopyridin-1 -yl optionally substituted with halogen; one or two of D 1, D 2 and D 3 is N, the remainder being CH; zero or one of D 4, D 5 and D 6 is N, the remainder being CH; each R c is independently selected from halogen, CF 3, alkyl, -O(1-6C alkyl), cyclopropyl, -O-(CH 2 CH 2)OMe, -S(1-6C alkyl), di(1-6C alkyl)amino, and a 5-6 membered azacycle; Ar is phenyl optionally substituted with one or more R d substituents; each R d is independently selected from alkyl, -O alky halogen, -S(1-6C alkyl), and CF 3, or two adjacent R d substituents together with the atoms to which they are attached form a 5-6 membered oxacyclic ring; hetAr 2 is pyridyl optionally substituted with one or more substituents independently selected from CF 3 and -O(1-6C alkyl); R 7a, R 7b and R 8 are independently H or methyl; and R 10 is H, Me or NH 2. A is H, CN, Cl, F, cyclopropyl, (1-4 C) alkyl or OMe; A 1 is H, Cl, Br, F, cyclopropyl, (1-4 C) alkyl or OMe; R 1 is -W-L 1 -hetAr 1; W is -CONR 3a - or -NR 3b CO-; R 3a and R 3b are each H or methyl; L 1 is a -(CR a R b) n - or n is 0 or 2; R a and R b are independently H, F, methyl, or cyclopropyl, or R a and R b together with the carbon to which they are attached form a cyclopropyl ring; hetAr 1 is heteroaryl ring selected from the structures: wherein m is 0 or 1 and each of said heteroaryl rings is optionally substituted with one or more R c substituents; or hetAr 1 is a 5,6-bicyclic heteroaryl having two ring heteroatoms independently selected from N, O and S, wherein at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from -O(1-6Calkyl alkyl, halogen and CF 3; or hetAr 1 is 2-oxopyridin-1 -yl optionally substituted with halogen; one or two of D 1, D 2 and D 3 is N, the remainder being CH; zero or one of D 4, D 5 and D 6 is N, the remainder being CH; each R c is independently selected from halogen, CF 3, alkyl, -O(1-6C alkyl), cyclopropyl, -O-(CH 2 CH 2)OMe, -S(1-6C alkyl), di(1-6C alkyl)amino, and a 5-6 membered azacycle; Ar is phenyl optionally substituted with one or more R d substituents; each R d is independently selected from alkyl, -O alky halogen, -S(1-6C alkyl), and CF 3, or two adjacent R d substituents together with the atoms to which they are attached form a 5-6 membered oxacyclic ring; hetAr 2 is pyridyl optionally substituted with one or more substituents independently selected from CF 3 and -O(1-6C alkyl); R 7a, R 7b and R 8 are independently H or methyl; and R 10 is H, Me or NH 2.