An operation procedure of an implantable micro-biosensor for continuously monitoring a physiological parameter of an analyte in a body during a detecting time period, the implantable micro-biosensor having a substrate which has a first surface and a second surface opposite to the first surface, at least one counter electrode which is disposed on the second surface of the substrate and includes a silver/silver halide, a first working electrode which includes a first sensing section, a chemical reagent layer which covers at least a portion of the first sensing section, and at least one second working electrode which includes a second sensing section disposed along and spaced apart from at least one side of the first sensing section by a distance of up to 0.2 mm, the first and second sensing sections (20, 30) being disposed on the first surface of the substrate, a surface material of the first sensing section including a first conductive material, a surface material of the second sensing section including a second conductive material different from the first conductive material, the operation procedure comprising steps of: reacting the chemical reagent layer with the analyte to produce a product; and driving the first sensing section by a first potential difference to make the first working electrode cooperate with the counter electrode during at least one first time section of the detecting time period and to perform a measurement action to obtain a physiological signal in response to the physiological parameter of the analyte, characterized in that the operation procedure further comprises steps of: driving the second sensing section of the second working electrode by a second potential difference to make the second working electrode cooperate with the counter electrode during at least one second time section of the detecting time period and to permit a concentration of an interfering substance to have a concentration gradient to consume interference; and driving the counter electrode by a third potential difference to permit the counter electrode to have a potential higher than that of the second working electrode and to make the second working electrode cooperate with the counter electrode during at least one third time section of the detecting time period to perform a regeneration action to regenerate silver halide, wherein the first and third time sections (T1, T3) do not overlap with each other, and the second time section does not overlap with the third time section when the quantity of the second working electrode is one. driving the first sensing section by a first potential difference to make the first working electrode cooperate with the counter electrode during at least one first time section of the detecting time period and to perform a measurement action to obtain a physiological signal in response to the physiological parameter of the analyte, characterized in that the operation procedure further comprises steps of: driving the second sensing section of the second working electrode by a second potential difference to make the second working electrode cooperate with the counter electrode during at least one second time section of the detecting time period and to permit a concentration of an interfering substance to have a concentration gradient to consume interference; and driving the counter electrode by a third potential difference to permit the counter electrode to have a potential higher than that of the second working electrode and to make the second working electrode cooperate with the counter electrode during at least one third time section of the detecting time period to perform a regeneration action to regenerate silver halide, wherein the first and third time sections (T1, T3) do not overlap with each other, and the second time section does not overlap with the third time section when the quantity of the second working electrode is one. driving the second sensing section of the second working electrode by a second potential difference to make the second working electrode cooperate with the counter electrode during at least one second time section of the detecting time period and to permit a concentration of an interfering substance to have a concentration gradient to consume interference; and driving the counter electrode by a third potential difference to permit the counter electrode to have a potential higher than that of the second working electrode and to make the second working electrode cooperate with the counter electrode during at least one third time section of the detecting time period to perform a regeneration action to regenerate silver halide, wherein the first and third time sections (T1, T3) do not overlap with each other, and the second time section does not overlap with the third time section when the quantity of the second working electrode is one.