A compound of formula I wherein Y is C; W is C; X 1 taken together with X 3 forms a double bond between Y and W; X 2 is Q 2; Q 1 is selected from -COOR 1, -CONR 1 R 2, -CONHCN, -CONH(SO 2 R 1), -CONR 1 OR 2, -C SR 1, -C OR 1, -CN, -COOCHR 1 C R 2, -COOCH 2 C NR 1 R 2 and tetrazol-5-yl; Q 2 is hydrogen; P is a single bond; V is -CR 8 R 9 -; U is -CR 10 R 11 -; R 1, R 2, R 8, R 9, R 10 and R 11 are at each occurrence in the compound of formula I independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heteroaryl and optionally substituted aryl; Ar 1 and Ar 2 are independently selected from an aryl and a heteroaryl ring carrying 0-4 same or different substituents R 12; R 12 is at each occurrence in the compound of formula I independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted aryl, -F, -Cl, -Br, -I, -CF 3, -Z-OR 13, -Z-NO 2, -Z-NR 13 OR 14, -Z-NR 13 R 14, -Z-SR 13, -Z-COOR 13, -Z-CONR 13 R 14, -Z-C SR 13, -Z-C NR 13 OR 14, -Z-CN, -Z-COR 13, -Z-COOCH 2 C R 13, -Z-COOCH 2 C NR 13 R 14, -Z-SOR 13, -Z-SO 2 R 13, -Z-SO 2 NR 13 R 14, -Z-P (OR 13)OR 14 and -Z-tetrazol-5-yl, wherein Z is a single bond, an optionally substituted methylene, an optionally substituted ethylene, an optionally substituted ethenylene or an ethinylene group; R 13 and R 14 are at each occurrence in the compound of formula I independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, optionally substituted heteroaryl and optionally substituted aryl, wherein the substituents of the optionally substituted heterocyclyl, optionally substituted heteroaryl, and optionally substituted aryl are at each occurrence in the compound of formula I independently selected from -F, -Cl, -Br, -I, -CF 3, -OR 15, -NO 2, -NR 15 R 16, -SR 15, -CH 2 OR 15, -CH 2 NR 15 R 16, -COOR 15, -CONR 15 R 16, -C SR 15, -C NR 15 OR 16, -CN, -COR 15, -SOR 15, -SO 2 R 15 and -SO 2 NR 15 R 16, wherein R 15 and R 16 can be the same or different and are at each occurrence in the coumpound of formula I independently selected from hydrogen, branched or linear C 1-6 alkyl, branched or linear C 2-6 alkenyl, branched or linear C 2-6 alkynyl, C 3-6 cycloalkyl and C 3-6 cycloalkenyl, and wherein the substituents of the optionally substituted methylene, optionally substituted ethylene and optionally substituted ethenylene are at each occurrence in the compound of formula I independently selected from -F, CF 3, NO 2, -COOR 17, -CONR 17 R 18, -CN, -COR 17, -SOR 17, -SO 2 R 17, -SO 2 NR 17 R 18, and -P (OR 17)OR 18, wherein R 17 and R 18 can be the same or different and are at each occurrence in the compound of formula I independently selected from hydrogen, branched or linear C 1-6 alkyl, branched or linear C 2-6 alkenyl, branched or linear C 2-6 alkynyl, C 3-6 cycloalkyl and C 3-6 cycloalkenyl, and pharmaceutically acceptable salts, solvates, diastereomers, enantiomers, tautomers and racemates thereof; provided that the compound is not 3-phenyl-5- -pyrrolyl-2-pentenenitrile, 3,5-diphenyl-2-enoic acid, t-butyl 3,5-diphenyl-2-pentenoate or ethyl 3,5-diphenyl-2-pentenoate.