A biomedical device for watertight sealing of an opening in a subject during a minimally invasive surgery procedure, the biomedical device: - configured for being introduced in said subject via said opening by an outer hollow tube; and - comprising at least two assemblies, each assembly comprising one flap as a proximal part, and one arm as a distal part, said one arm being connected to said one flap; wherein the flap of each assembly comprises a first connecting portion (1.2), and the arm of each assembly comprises a second connecting portion (2.1), the first connection portion (1.2) and the second connection portion (2.1) forming a hinge connecting said one arm and said one flap in a manner such that said one arm is rotatably connected to said one flap between a first relative position in which the arm and the flap form an angle of substantially 180° and a second relative position in which the arm and the flap form an angle of substantially 90°; and - comprising assembling means connected to the at least two assemblies, said assembling means being configured such that the proximal part of each assembly is located in a plane perpendicular to a reference axis; - each assembly having a delivery configuration, a deployed configuration, and a sealed configuration; - each assembly having i) outwards deployment means for switching from the delivery configuration to the deployed configuration, and ii) inwards deployment means for switching from the deployed configuration to the sealed configuration; wherein: - in the delivery configuration, the flap and the arm of each assembly are oriented parallel to the reference axis, each assembly extends along a direction substantially parallel to the reference axis, and the at least two assemblies together form a hollow cylinder for receiving an inner hollow tube therethrough; an axis of this inner hollow tube coinciding with the reference axis, the flap and the arm forming an angle of substantially 180°; - in the deployed configuration, the flap of each assembly remains parallel to the reference axis along the inner hollow tube, and the arm of each assembly is deployed outwardly relative to the reference axis and positioned at substantially 90° relative to the reference axis, the flap and the arm forming an angle of substantially 90°; and - in the sealed configuration, the flap of each assembly is deployed inwardly relative to the reference axis and positioned at substantially 90° relative to the reference axis, such that the flaps are joined in an edge to edge arrangement thereby closing and sealing said opening in a watertight manner, and the arm of each assembly remains positioned at substantially 90° relative to the reference axis, the flap and the arm forming an angle of substantially 180°. - configured for being introduced in said subject via said opening by an outer hollow tube; and - comprising at least two assemblies, each assembly comprising one flap as a proximal part, and one arm as a distal part, said one arm being connected to said one flap; wherein the flap of each assembly comprises a first connecting portion (1.2), and the arm of each assembly comprises a second connecting portion (2.1), the first connection portion (1.2) and the second connection portion (2.1) forming a hinge connecting said one arm and said one flap in a manner such that said one arm is rotatably connected to said one flap between a first relative position in which the arm and the flap form an angle of substantially 180° and a second relative position in which the arm and the flap form an angle of substantially 90°; and - comprising assembling means connected to the at least two assemblies, said assembling means being configured such that the proximal part of each assembly is located in a plane perpendicular to a reference axis; - each assembly having a delivery configuration, a deployed configuration, and a sealed configuration; - each assembly having i) outwards deployment means for switching from the delivery configuration to the deployed configuration, and ii) inwards deployment means for switching from the deployed configuration to the sealed configuration; wherein: - in the delivery configuration, the flap and the arm of each assembly are oriented parallel to the reference axis, each assembly extends along a direction substantially parallel to the reference axis, and the at least two assemblies together form a hollow cylinder for receiving an inner hollow tube therethrough; an axis of this inner hollow tube coinciding with the reference axis, the flap and the arm forming an angle of substantially 180°; - in the deployed configuration, the flap of each assembly remains parallel to the reference axis along the inner hollow tube, and the arm of each assembly is deployed outwardly relative to the reference axis and positioned at substantially 90° relative to the reference axis, the flap and the arm forming an angle of substantially 90°; and - in the sealed configuration, the flap of each assembly is deployed inwardly relative to the reference axis and positioned at substantially 90° relative to the reference axis, such that the flaps are joined in an edge to edge arrangement thereby closing and sealing said opening in a watertight manner, and the arm of each assembly remains positioned at substantially 90° relative to the reference axis, the flap and the arm forming an angle of substantially 180°.