A pinch valve in combination with a replaceable sleeve, the pinch valve comprising: an upper casing and a lower casing each comprising a sleeve rim (125, 127, 165, 167) engageable with a section of a lip (16, 18) of the replaceable sleeve, the upper casing and the lower casing being pivotably connected and being pivotable between a closed position where the sleeve rim (125, 127, 165, 167) of the upper casing and the lower casing is engaged to the lip (16, 18) of the replaceable sleeve and an open position where the sleeve rim (125, 127, 165, 167) of at least one of the upper casing and the lower casing is disengaged from the lip (16, 18) of the replaceable sleeve; and a synchronization mechanism comprising: a first synchronisation shaft; a second synchronisation shaft; an upper pinch element operatively engaged with the synchronisation shaft; a lower pinch element which one end is pivotally connected to the first synchronisation shaft and which opposed end is releasably connected to the second synchronisation shaft, the said lower pinch element being selectively operatively engageable with and disengageable from the second synchronisation shaft, each one of the upper pinch element and the lower pinch element extending on a respective side of the replaceable sleeve when operatively engaged to the first synchronisation shaft and the second synchronisation shaft, and being movable with respect to one another, the lower pinch element being disengaged from the second synchronisation shaft when the upper casing and the lower casing are in the open position. an upper casing and a lower casing each comprising a sleeve rim (125, 127, 165, 167) engageable with a section of a lip (16, 18) of the replaceable sleeve, the upper casing and the lower casing being pivotably connected and being pivotable between a closed position where the sleeve rim (125, 127, 165, 167) of the upper casing and the lower casing is engaged to the lip (16, 18) of the replaceable sleeve and an open position where the sleeve rim (125, 127, 165, 167) of at least one of the upper casing and the lower casing is disengaged from the lip (16, 18) of the replaceable sleeve; and a synchronization mechanism comprising: a first synchronisation shaft; a second synchronisation shaft; an upper pinch element operatively engaged with the synchronisation shaft; a lower pinch element which one end is pivotally connected to the first synchronisation shaft and which opposed end is releasably connected to the second synchronisation shaft, the said lower pinch element being selectively operatively engageable with and disengageable from the second synchronisation shaft, each one of the upper pinch element and the lower pinch element extending on a respective side of the replaceable sleeve when operatively engaged to the first synchronisation shaft and the second synchronisation shaft, and being movable with respect to one another, the lower pinch element being disengaged from the second synchronisation shaft when the upper casing and the lower casing are in the open position. a first synchronisation shaft; a second synchronisation shaft; an upper pinch element operatively engaged with the synchronisation shaft; a lower pinch element which one end is pivotally connected to the first synchronisation shaft and which opposed end is releasably connected to the second synchronisation shaft, the said lower pinch element being selectively operatively engageable with and disengageable from the second synchronisation shaft, each one of the upper pinch element and the lower pinch element extending on a respective side of the replaceable sleeve when operatively engaged to the first synchronisation shaft and the second synchronisation shaft, and being movable with respect to one another, the lower pinch element being disengaged from the second synchronisation shaft when the upper casing and the lower casing are in the open position.