A system for 3D microfabrication of a structure, comprising: a light source (10; 110) configured for projecting light within an optical path, the light source emitting light at a wavelength configured for initiating photopolymerization; a spatial light modulator (13; 84; 113) disposed within the optical path and configured for modulating light from the light source responsive to a set of digital masks (11; 111) corresponding to layers of the structure; projection optics (14; 82; 114) configured to focus the modulated light to an optical plane; a stage (15; 92; 115) supporting a substrate comprising an array of wells, each well in the array of wells filled with a photopolymerizable material within the optical plane, wherein the stage is configured for movement along at least one axis; a transparent window configured for contact with the photopolymerizable material, wherein an interface between the window and the photopolymerizable material is substantially coincident with the optical plane; and a computer processor configured for: controlling the spatial light modulator (13; 84; 113) to project a sequence of images corresponding to the set of digital masks (11; 111) into one or more wells of the array of wells; and coordinating movement of the stage (15; 92; 115) to continuously move a position of the optical plane within the photopolymerizable material to sequentially project each image of the sequence to generate a layerless structure within the one or more wells by continuously and progressively photopolymerizing the photopolymerizable material along the at least one axis. a light source (10; 110) configured for projecting light within an optical path, the light source emitting light at a wavelength configured for initiating photopolymerization; a spatial light modulator (13; 84; 113) disposed within the optical path and configured for modulating light from the light source responsive to a set of digital masks (11; 111) corresponding to layers of the structure; projection optics (14; 82; 114) configured to focus the modulated light to an optical plane; a stage (15; 92; 115) supporting a substrate comprising an array of wells, each well in the array of wells filled with a photopolymerizable material within the optical plane, wherein the stage is configured for movement along at least one axis; a transparent window configured for contact with the photopolymerizable material, wherein an interface between the window and the photopolymerizable material is substantially coincident with the optical plane; and a computer processor configured for: controlling the spatial light modulator (13; 84; 113) to project a sequence of images corresponding to the set of digital masks (11; 111) into one or more wells of the array of wells; and coordinating movement of the stage (15; 92; 115) to continuously move a position of the optical plane within the photopolymerizable material to sequentially project each image of the sequence to generate a layerless structure within the one or more wells by continuously and progressively photopolymerizing the photopolymerizable material along the at least one axis. controlling the spatial light modulator (13; 84; 113) to project a sequence of images corresponding to the set of digital masks (11; 111) into one or more wells of the array of wells; and coordinating movement of the stage (15; 92; 115) to continuously move a position of the optical plane within the photopolymerizable material to sequentially project each image of the sequence to generate a layerless structure within the one or more wells by continuously and progressively photopolymerizing the photopolymerizable material along the at least one axis.