mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula and their pharmaceutically acceptable salt, solvate or polymorph thereof wherein R 1 is H, fluorine or methyl; R 2 is H, halogen or C 1-3 alkyl; R 3 is C 1-6 alkyl optionally substituted by one or more substituents independently selected from aryloxy, heterocycle, halogen, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, nitrile, or C 1-6 alkoxy; or wherein R 3 is an alkylaryl optionally substituted by one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile, or C 1-6 alkoxy; R 4 is C 1-6 alkyl optionally substituted by one or more substituents independently selected from hydroxyl, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl or aryl optionally further substituted by C 1-6 alkyl, and C 3-7 cycloalkyl optionally further substituted by C 1-6 alkyl; or wherein R 4 is an alkylaryl optionally substituted by one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile, or C 1-6 alkoxy. R 1 is H, fluorine or methyl; R 2 is H, halogen or C 1-3 alkyl; R 3 is C 1-6 alkyl optionally substituted by one or more substituents independently selected from aryloxy, heterocycle, halogen, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, nitrile, or C 1-6 alkoxy; or wherein R 3 is an alkylaryl optionally substituted by one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile, or C 1-6 alkoxy; R 4 is C 1-6 alkyl optionally substituted by one or more substituents independently selected from hydroxyl, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl or aryl optionally further substituted by C 1-6 alkyl, and C 3-7 cycloalkyl optionally further substituted by C 1-6 alkyl; or wherein R 4 is an alkylaryl optionally substituted by one or more substituents independently selected from halogen, aryloxy, aryl, alkylamino, dialkylamino, C 1-6 alkyl, carboxylic acid, carboxylic ester, carboxylic amide, sulfonamide, nitrile, or C 1-6 alkoxy.
An isothiocyanic acid ester for use in preventing and/or treating hairy wart disease by administration to a hoof of an ungulate, wherein the isothiocyanic acid ester is a C 2-6 alkenyl isothiocyanate, aryl isothiocyanate, C 1-6 alkyl isothiocyanate, phenyl C 1-6 alkyl isothiocyanate or C 3-6 cycloalkyl isothiocyanate.
A cosmetic composition comprising particles dispersed in a cosmetically acceptable carrier, wherein the particles comprise polymer, redox dye and reducing agent.
A fiber-containing mortar mixture characterized in that it contains regenerated cellulose fibers having cellulose II-type structure, a length from 100 to 700 μm, and a diameter from 5 to 20 μm, and whose L/D ratio is between 25 and 50.
A CAMERA DOLLY USED FOR FILMING, that includes a vertical telescopic column adapted to support a filming head or camera on an end thereof, the dolly comprising: - a movable tube placed externally around said telescopic column, - said movable tube being connected to the very end of said telescopic column, - said movable tube moving in relation to said telescopic column; and - a movable supporting element that moves along said movable tube, wherein a tilt axis is positioned on said movable supporting element, and a camera being placeable onto said tilt supporting element characterised in that said dolly further comprising a supporting platform and further comprising under said supporting platform a pan movement mechanism, said pan movement mechanism having a set of brushes thereby permitting unlimited 360° rotation. - a movable tube placed externally around said telescopic column, - said movable tube being connected to the very end of said telescopic column, - said movable tube moving in relation to said telescopic column; and - a movable supporting element that moves along said movable tube, wherein a tilt axis is positioned on said movable supporting element, and a camera being placeable onto said tilt supporting element characterised in that said dolly further comprising a supporting platform and further comprising under said supporting platform a pan movement mechanism, said pan movement mechanism having a set of brushes thereby permitting unlimited 360° rotation.
A waste heat recovery system, comprising: a closed fluid circuit through which an organic motive fluid flows, heat exchanger means for transferring heat from waste heat gases to said motive fluid, a high pressure flash chamber for receiving the motive fluid which exits the heat exchanger means and for flashing the motive fluid which exits the heat exchanger means into a high pressure flashed vapor portion, a low pressure flash chamber for receiving a non-flashed liquid discharge from said high pressure flash chamber and for flashing the non-flashed liquid discharge producing a low pressure flashed vapor portion, a high pressure turbine module which receives said high pressure flashed vapor portion to produce power, a low pressure turbine module which receives a combined flow of motive fluid vapor comprising said low pressure flashed vapor portion and discharge vapor from said high pressure turbine module whereby additional power is produced, a direct contact recuperator, a condenser for condensing discharge vapor from the low pressure turbine module, and a cycle pump for delivering at least a portion of the motive fluid condensate from said condenser to said direct contact recuperator for mixing with the high pressure turbine module discharge vapor, whereby the mixed flow produced exiting said direct contact recuperator is combined with the low pressure flashed vapor portion to produce the combined flow supplied to the low pressure turbine module. a closed fluid circuit through which an organic motive fluid flows, heat exchanger means for transferring heat from waste heat gases to said motive fluid, a high pressure flash chamber for receiving the motive fluid which exits the heat exchanger means and for flashing the motive fluid which exits the heat exchanger means into a high pressure flashed vapor portion, a low pressure flash chamber for receiving a non-flashed liquid discharge from said high pressure flash chamber and for flashing the non-flashed liquid discharge producing a low pressure flashed vapor portion, a high pressure turbine module which receives said high pressure flashed vapor portion to produce power, a low pressure turbine module which receives a combined flow of motive fluid vapor comprising said low pressure flashed vapor portion and discharge vapor from said high pressure turbine module whereby additional power is produced, a direct contact recuperator, a condenser for condensing discharge vapor from the low pressure turbine module, and a cycle pump for delivering at least a portion of the motive fluid condensate from said condenser to said direct contact recuperator for mixing with the high pressure turbine module discharge vapor, whereby the mixed flow produced exiting said direct contact recuperator is combined with the low pressure flashed vapor portion to produce the combined flow supplied to the low pressure turbine module.
A mutually linkable bicycle which includes a frame comprising a head tube, an immobile tube of the head tube, a front fork and a top tube, the immobile tube being interposed between the top tube and the head tube of the frame to divide the frame into two and a bearing portion mounted at an end portion of the top tube or the immobile tube to axially support the opposed end portions so that the top tube and the immobile tube are disposed so as to be capable of relative rotation, characterized in the mutually linkable bicycle comprising: pin holes (22, 62) which are respectively formed in the outer periphery of the bearing portion and in the outer periphery of the end portion axially supported therein in such a way as to coincide with each other when the front fork of the bicycle is put in a line; clutch means which is formed when a fixing pin is inserted into the two coinciding pin holes (22, 62) in such a way as to be freely inserted or drawn out and which is mounted between the top tube and the immobile tube; a screw portion which is mounted at the end of the fixing pin; and a synchronizer having a nut which is attached to the inner face of the front fork and to which the screw portion is spirally inserted, so as to control relative rotation of the top tube according to rotation of the head tube. pin holes (22, 62) which are respectively formed in the outer periphery of the bearing portion and in the outer periphery of the end portion axially supported therein in such a way as to coincide with each other when the front fork of the bicycle is put in a line; clutch means which is formed when a fixing pin is inserted into the two coinciding pin holes (22, 62) in such a way as to be freely inserted or drawn out and which is mounted between the top tube and the immobile tube; a screw portion which is mounted at the end of the fixing pin; and a synchronizer having a nut which is attached to the inner face of the front fork and to which the screw portion is spirally inserted, so as to control relative rotation of the top tube according to rotation of the head tube.
A surgical apparatus for positioning within a tissue tract accessing an underlying body cavity, which comprises: a proximal portion bendable by a user between an initial position and a bent position; a distal portion disposed distally with respect to the proximal portion; characterised by at least one bendable structure attached to the proximal portion extending between a first end and a second end of the proximal portion, the at least one bendable structure configured to maintain the proximal portion in the bent position until the user selectively returns the proximal portion towards its initial position. a proximal portion bendable by a user between an initial position and a bent position; a distal portion disposed distally with respect to the proximal portion; characterised by at least one bendable structure attached to the proximal portion extending between a first end and a second end of the proximal portion, the at least one bendable structure configured to maintain the proximal portion in the bent position until the user selectively returns the proximal portion towards its initial position.
A contrast agent for medical diagnostics and imaging comprising a plurality of metal nanoparticles, wherein said plurality of metal nanoparticles are encapsulated in a non-proteinaceous biocompatible or biodegradable matrix particle and/or attached to a non-proteinaceous biocompatible or biodegradable matrix particle, the matrix of the matrix particles being selected from the group consisting of a carbohydrate, a lipid, a synthetic polymer, an aqueous liquid, a surfactant and an organic liquid, or a mixture thereof, wherein said metal nanoparticles have a diameter between 1 and 100 nm characterised in that said metal nanoparticles are present in a concentration of at least 2% volume/volume in said matrix.
A flexible organic photovoltaic device prepared from a transparent conductor film, wherein the OPV device comprises: the flexible transparent conductor film, which includes: a support substrate; a flexible transparent substrate; and a transfer release layer laminated between the support substrate and the flexible transparent substrate; and a first transparent conductor layer on top of the flexible transparent substrate; a first charge-collection layer coated on top of the first transparent conductor layer; a bulk heterojunction photoactive layer coated on top of the first charge-collection layer; a second charge-collection layer coated on top of the bulk heterojunction photoactive layer, wherein the second charge-collection layer is of opposite polarity as the first charge- collection layer, and wherein the second charge-collection layer is formed of a different material than the first charge-collection layer; a second transparent conductor layer coated on top of the second charge-collection layer; and a transparent pressure-sensitive adhesive on the second transparent conductor layer on an opposite side of the flexible transparent conductor film from the support substrate and capable of adhering the transparent conductor layer to a curved surface of a semi-transparent object after the support substrate is removed from the opposite side of the flexible transparent conductor film. the flexible transparent conductor film, which includes: a support substrate; a flexible transparent substrate; and a transfer release layer laminated between the support substrate and a support substrate; a flexible transparent substrate; and a transfer release layer laminated between the support substrate and the flexible transparent substrate; and a first transparent conductor layer on top of the flexible transparent substrate; a first charge-collection layer coated on top of the first transparent conductor layer; a bulk heterojunction photoactive layer coated on top of the first charge-collection layer; a second charge-collection layer coated on top of the bulk heterojunction photoactive layer, wherein the second charge-collection layer is of opposite polarity as the first charge- collection layer, and wherein the second charge-collection layer is formed of a different material than the first charge-collection layer; a second transparent conductor layer coated on top of the second charge-collection layer; and a transparent pressure-sensitive adhesive on the second transparent conductor layer on an opposite side of the flexible transparent conductor film from the support substrate and capable of adhering the transparent conductor layer to a curved surface of a semi-transparent object after the support substrate is removed from the opposite side of the flexible transparent conductor film.
Working method for processing scrap metal stored on a scrap-metal collecting site using a shear press provided with a filling tray for receiving a quantity of scrap metal to be processed and provided with an outlet in the form of a vertical guillotine gate with cutting blades for cutting through the scrap metal which are released from the tray through the outlet by means of a hydraulic tappet, the shear press being provided with a hydraulic unit for the supply of actuators and hydraulic motors of the tappet, the blades and the press, using a filling vehicle for filling the tray with the scrap metal to be processed, the shear press and the filling vehicle being two machines capable of moving simultaneously, the method making use of a self-powered shear press, i.e. a shear press provided with its own movement means and an autonomous mobility such that it is movable inside a site, and provided with a remote control configured for commands, both for operations of the shear press and its movement, the method comprising the following steps: - of providing a storage zone with the scrap metal to be processed; - of proceeding cyclically with the: movement of the shear press in the storage zone or along the storage zone in the range of the filling vehicle; filling of the tray of the shear press with the scrap metal to be processed using the filling vehicle; making the shear press operate to process the scrap metal filled in the tray and to release the processed scrap metal through the outlet; movement of the shear press for the processing of a next pile of scrap metal to be processed by leaving in place the processed scrap metal released from the tray. - of providing a storage zone with the scrap metal to be processed; - of proceeding cyclically with the: movement of the shear press in the storage zone or along the storage zone in the range of the filling vehicle; filling of the tray of the shear press with the scrap metal to be processed using the filling vehicle; making the shear press operate to process the scrap metal filled in the tray and to release the processed scrap metal through the outlet; movement of the shear press for the processing of a next pile of scrap metal to be processed by leaving in place the processed scrap metal released from the tray. movement of the shear press in the storage zone or along the storage zone in the range of the filling vehicle; filling of the tray of the shear press with the scrap metal to be processed using the filling vehicle; making the shear press operate to process the scrap metal filled in the tray and to release the processed scrap metal through the outlet; movement of the shear press for the processing of a next pile of scrap metal to be processed by leaving in place the processed scrap metal released from the tray.
A B-pillar central beam (100, 200, 300, 400, 500) made of steel comprising: hard zones and soft zones, wherein the soft zones have a lower yield strength and/or tensile strength than the hard zones, an upper region with an upper fastening portion for fastening to a roof member and a lower region with a lower fastening portion for fastening to a sill member, and including a lower soft zone (211, 221, 311, 410, 420, 430, 440, 512, 522) between the lower fastening portion and 50% of the B-pillar central beam height, and an upper soft zone (210, 220, 310, 410, 420, 430, 440, 510, 520) between the upper fastening portion and the 50% of the B-pillar central beam height, wherein the upper soft zone (210, 220, 310, 410, 420, 430, 440, 510, 520) has a higher yield strength and/or tensile strength than the lower soft zone (211, 221, 311, 410, 420, 430, 440, 512, 522), characterized in that the upper and lower fastening portions (101, 105) are predominantly hard zones. hard zones and soft zones, wherein the soft zones have a lower yield strength and/or tensile strength than the hard zones, an upper region with an upper fastening portion for fastening to a roof member and a lower region with a lower fastening portion for fastening to a sill member, and including a lower soft zone (211, 221, 311, 410, 420, 430, 440, 512, 522) between the lower fastening portion and 50% of the B-pillar central beam height, and an upper soft zone (210, 220, 310, 410, 420, 430, 440, 510, 520) between the upper fastening portion and the 50% of the B-pillar central beam height, wherein a lower soft zone (211, 221, 311, 410, 420, 430, 440, 512, 522) between the lower fastening portion and 50% of the B-pillar central beam height, and an upper soft zone (210, 220, 310, 410, 420, 430, 440, 510, 520) between the upper fastening portion and the 50% of the B-pillar central beam height, wherein the upper soft zone (210, 220, 310, 410, 420, 430, 440, 510, 520) has a higher yield strength and/or tensile strength than the lower soft zone (211, 221, 311, 410, 420, 430, 440, 512, 522), characterized in that the upper and lower fastening portions (101, 105) are predominantly hard zones.
An automated fiber bundle placement apparatus comprising: a supply device configured to set a plurality of bobbins around which fiber bundles are wound, and deliver the fiber bundles from each of the bobbins; a placement head for performing placement of each of the fiber bundles supplied from the supply device on a placement die; and an articulated robot which has an arm to which the placement head is attached and moves the placement head for the placement, in which the placement head is attached to the articulated robot via a rotation mechanism, wherein the placement head is attached to a rotation section that is rotationally driven, the articulated robot includes a guide mechanism that guides the fiber bundle from the supply device toward the placement head, the guide mechanism includes: a plurality of tow guides provided corresponding to each of the fiber bundles, a support member that supports the tow guide, and characterized by a support mechanism attached to the arm and in which the support member is attached so that the support member is in a state of being supported by the arm, the support member being displaceable in a width direction orthogonal to an extending direction of the arm in a plane. a supply device configured to set a plurality of bobbins around which fiber bundles are wound, and deliver the fiber bundles from each of the bobbins; a placement head for performing placement of each of the fiber bundles supplied from the supply device on a placement die; and an articulated robot which has an arm to which the placement head is attached and moves the placement head for the placement, in which the placement head is attached to the articulated robot via a rotation mechanism, wherein the placement head is attached to a rotation section that is rotationally driven, the articulated robot includes a guide mechanism that guides the fiber bundle from the supply device toward the placement head, the guide mechanism includes: a plurality of tow guides provided corresponding to each of the fiber bundles, a support member that supports the tow guide, and characterized by a support mechanism attached to the arm and in which the support member is attached so that the support member is in a state of being supported by the arm, the support member being displaceable in a width direction orthogonal to an extending direction of the arm in a plane. a plurality of tow guides provided corresponding to each of the fiber bundles, a support member that supports the tow guide, and characterized by a support mechanism attached to the arm and in which the support member is attached so that the support member is in a state of being supported by the arm, the support member being displaceable in a width direction orthogonal to an extending direction of the arm in a plane.
Heat generator for well stimulation in a perforation region of a borehole, comprising a tubular fuel vessel with two or more mutually separated, closed segments which are arranged in the longitudinal one behind the other and are each at least partially filled with fuel (30, 32, 33), and at least one igniter for igniting the fuel in at least one of the segments, characterised in that the fuel vessel comprises two or more closed tubular containers which form the segments and of which the end faces are connected via connecting elements so that the fuel can be ignited in a subsequent segment by reason of the heat development during the burn-off of the fuel in a preceding segment, wherein the end faces contact one another and are manufactured from a material which ensures sufficient heat transfer for igniting the fuel (30, 32, 33) in the subsequent segment.
A synthetic miRNA nucleic acid molecule comprising a sequence with at least 80% sequence identity to mature human miR-124 sequence for use in a therapy of a cancer.