An apparatus for creating a representation of an in-progress biological sequence, the apparatus comprising: a memory for storing a set of instructions; and a processor for executing the set of instructions, wherein the instructions, when executed, cause the processor to: provide a representation of at least a portion of the in-progress biological sequence for presentation on a graphical display; receive an input corresponding to an amendment to the portion of the in-progress biological sequence; identify, based at least in part upon a partial match with the amended in-progress biological sequence, one or more biological sequence scaffold candidates selected from an active database of biological sequence scaffold candidates, wherein the one or more biological sequence scaffold candidates comprises a minimum of at least 2 amino acids or at least 10 nucleotides; provide the one or more biological sequence scaffold candidates for presentation on the graphical display as option(s) for selection by a user for the amendment; receive an indication of user selection of a first biological sequence scaffold candidate of the one or more biological sequence scaffold candidates provided; and append the first biological sequence scaffold candidate to the portion of the in-progress biological sequence or replace or partially replace the portion of the in-progress biological sequence with the first biological scaffold candidate, causing the regeneration of the graphical display to include the first biological sequence scaffold candidate in the in-progress biological sequence. a memory for storing a set of instructions; and a processor for executing the set of instructions, wherein the instructions, when executed, cause the processor to: provide a representation of at least a portion of the in-progress biological sequence for presentation on a graphical display; receive an input corresponding to an amendment to the portion of the in-progress biological sequence; identify, based at least in part upon a partial match with the amended in-progress biological sequence, one or more biological sequence scaffold candidates selected from an active database of biological sequence scaffold candidates, wherein the one or more biological sequence scaffold candidates comprises a minimum of at least 2 amino acids or at least 10 nucleotides; provide the one or more biological sequence scaffold candidates for presentation on the graphical display as option(s) for selection by a user for the amendment; receive an indication of user selection of a first biological sequence scaffold candidate of the one or more biological sequence scaffold candidates provided; and append the first biological sequence scaffold candidate to the portion of the in-progress biological sequence or replace or partially replace the portion of the in-progress biological sequence with the first biological scaffold candidate, causing the regeneration of the graphical display to include the first biological sequence scaffold candidate in the in-progress biological sequence. provide a representation of at least a portion of the in-progress biological sequence for presentation on a graphical display; receive an input corresponding to an amendment to the portion of the in-progress biological sequence; identify, based at least in part upon a partial match with the amended in-progress biological sequence, one or more biological sequence scaffold candidates selected from an active database of biological sequence scaffold candidates, wherein the one or more biological sequence scaffold candidates comprises a minimum of at least 2 amino acids or at least 10 nucleotides; provide the one or more biological sequence scaffold candidates for presentation on the graphical display as option(s) for selection by a user for the amendment; receive an indication of user selection of a first biological sequence scaffold candidate of the one or more biological sequence scaffold candidates provided; and append the first biological sequence scaffold candidate to the portion of the in-progress biological sequence or replace or partially replace the portion of the in-progress biological sequence with the first biological scaffold candidate, causing the regeneration of the graphical display to include the first biological sequence scaffold candidate in the in-progress biological sequence.