A system, comprising: a processor; and a computer-readable medium coupled to the processor, the computer-readable medium storing instructions which, when executed by the processor, cause the processor to perform operations comprising: projecting a mask on an image of a staining assay, the mask being generated from images of more than one anatomical assay, wherein the images of anatomical assays comprise a first image of a first slide of a first cut of a tissue specimen stained with a first macro-anatomical assay and a second image of a second slide of a second cut of the tissue specimen stained with a second micro-anatomical assay, wherein the second cut of the tissue specimen is adjacent to the first cut, the first macro-anatomical assay identifying macro-anatomical structures, the second micro-anatomical assay identifying anatomical information detected at a different scale than the macro-anatomical structures in the first macro-anatomical assay stained slide providing additional detail about a part of the first macro-anatomical assay stained slide, the mask generation using macro-anatomical and micro-anatomical features, wherein the macro-anatomical feature is one or more of a tumor, a region of a tumor, an outline of a tumor gland, an invasive margin of a tumor, a primary tumor, and a site of metastasis, wherein the micro-anatomical feature is at least one of a presence of a specific structure within a tumor and a property of the tumor; and detecting a feature of interest in the image of the staining assay based on the mask; wherein images of the staining assay and the one or more anatomical assays correspond to images of tissue sections from the same tissue specimen. a processor; and a computer-readable medium coupled to the processor, the computer-readable medium storing instructions which, when executed by the processor, cause the processor to perform operations comprising: projecting a mask on an image of a staining assay, the mask being generated from images of more than one anatomical assay, wherein the images of anatomical assays comprise a first image of a first slide of a first cut of a tissue specimen stained with a first macro-anatomical assay and a second image of a second slide of a second cut of the tissue specimen stained with a second micro-anatomical assay, wherein the second cut of the tissue specimen is adjacent to the first cut, the first macro-anatomical assay identifying macro-anatomical structures, the second micro-anatomical assay identifying anatomical information detected at a different scale than the macro-anatomical structures in the first macro-anatomical assay stained slide providing additional detail about a part of the first macro-anatomical assay stained slide, the mask generation using macro-anatomical and micro-anatomical features, wherein the macro-anatomical feature is one or more of a tumor, a region of a tumor, an outline of a tumor gland, an invasive margin of a tumor, a primary tumor, and a site of metastasis, wherein the micro-anatomical feature is at least one of a presence of a specific structure within a tumor and a property of the tumor; and detecting a feature of interest in the image of the staining assay based on the mask; wherein images of the staining assay and the one or more anatomical assays correspond to images of tissue sections from the same tissue specimen.