A compound of Formula II: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from cyclohexyl, cyclopentyl, cycloheptyl, 3,3-difluorocyclobutyl, 4,4-difluorocyclohexyl, and bicyclo[2.2.1]heptanyl; R 3 is selected from 3-fluorophenyl, 3-methylphenyl, 3-chlorophenyl, and thien-2-ylmethyl; R 4 is selected from 1-(methylmethoxycarbonylamino)ethyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1-ethoxycarbonylpiperidin-2-yl, 1-ethoxycarbonylpyrrolidin-2-yl, 1H-benzimidazol-1-ylmethyl, 1H-indazol-3-ylmethyl, indolin-1-ylmethyl, 1H-indol-3-ylmethyl, 1H-indol-5-ylmethyl, 1H-pyrrolo[2,3-b]pyridine-3-ylmethyl, 1H-pyrrolo[3,2-b]pyridin-3-ylmethyl, 1-methoxycarbonylpiperidin-2-yl, 1-methoxycarbonylpyrrolidin-2-yl, 2-fluoropyridin-3-ylaminomethyl, 2-imino-4-fluoropyridin-1-ylmethyl, 2-methoxyphenylaminomethyl, 2-methyl-1H-benzimidazol-1-ylmethyl, 2-methylimidazol-1-ylmethyl, 2-trifluoromethyl-1H-imidazol-1-yl, 3-cyanophenylaminomethyl, 3-fluoropyridin-2-ylaminomethyl, 3-methoxyphenylaminomethyl, 4-(1,3,4-oxadiazole-2-yl)phenylaminomethyl, 4-(dimethylaminocarbonyloxy)phenylmethyl, 4,5-dichloroimidazol-1-ylmethyl, 4-cyanophenylaminomethyl, 4-fluorophenylaminomethyl, 4-fluoropyridin-2-ylaminomethyl, 4-hydroxyphenylmethyl, 4-methoxycarbonylmorpholin-3-yl, 4-methoxycarbonylpiperazin-1-ylmethyl, 4-methoxyphenylaminomethyl, 4-methylcarbonyloxyphenylmethyl, 5-fluoropyridin-2-aminomethyl, 5-fluoropyridin-2-oxymethyl, 6-fluoropyridin-3-ylaminomethyl, benzomorpholin-4-ylmethyl, methoxycarbonylaminomethyl, methylmethoxycarbonylaminomethyl, methylphenylaminomethyl, phenylaminomethyl, pyridin-2-oxymethyl, pyridin-2-ylaminomethyl, pyridin-2-yloxymethyl, pyridin-3-oxymethyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl, thiazol-4-ylmethyl, and thien-2-ylmethyl; and R 10 is selected from methyl, hydrogen, fluoro, chloro, and bromo, wherein: when R 1 is cyclopentyl or cyclohexyl, and R 3 is thien-2-ylmethyl, then R 4 is other than thien-2-ylmethyl, 1H-benizimidazol-1-ylmethyl, 1H-indol-3-ylmethyl, or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is hydrogen, and R 3 is 3-fluorophenyl, 3-methylphenyl, or 3-chlorophenyl, then R 4 is other than thien-2-ylmethyl; when R 1 is cyclopentyl, R 10 is methyl and R 3 is 3-fluorophenyl, then R 4 is other than thien-2-ylmethyl or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is fluoro and R 3 is 3-methylphenyl, then R 4 is other than thien-2-ylmethyl or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is fluoro and R 3 is 3-fluorophenyl, then R 4 is other than thien-2-ylmethyl; when R 1 is cyclohexyl, R 10 is hydrogen, and R 3 is 3-methylphenyl, or 3-chlorophenyl, then R 4 is other than thien-2-ylmethyl; and when R 1 is cyclohexyl, R 10 is hydrogen, and R 3 is 3-fluorophenyl, then R 4 is other than 1H-benzotriazol-1-ylmethyl. R 1 is selected from cyclohexyl, cyclopentyl, cycloheptyl, 3,3-difluorocyclobutyl, 4,4-difluorocyclohexyl, and bicyclo[2.2.1]heptanyl; R 3 is selected from 3-fluorophenyl, 3-methylphenyl, 3-chlorophenyl, and thien-2-ylmethyl; R 4 is selected from 1-(methylmethoxycarbonylamino)ethyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1-ethoxycarbonylpiperidin-2-yl, 1-ethoxycarbonylpyrrolidin-2-yl, 1H-benzimidazol-1-ylmethyl, 1H-indazol-3-ylmethyl, indolin-1-ylmethyl, 1H-indol-3-ylmethyl, 1H-indol-5-ylmethyl, 1H-pyrrolo[2,3-b]pyridine-3-ylmethyl, 1H-pyrrolo[3,2-b]pyridin-3-ylmethyl, 1-methoxycarbonylpiperidin-2-yl, 1-methoxycarbonylpyrrolidin-2-yl, 2-fluoropyridin-3-ylaminomethyl, 2-imino-4-fluoropyridin-1-ylmethyl, 2-methoxyphenylaminomethyl, 2-methyl-1H-benzimidazol-1-ylmethyl, 2-methylimidazol-1-ylmethyl, 2-trifluoromethyl-1H-imidazol-1-yl, 3-cyanophenylaminomethyl, 3-fluoropyridin-2-ylaminomethyl, 3-methoxyphenylaminomethyl, 4-(1,3,4-oxadiazole-2-yl)phenylaminomethyl, 4-(dimethylaminocarbonyloxy)phenylmethyl, 4,5-dichloroimidazol-1-ylmethyl, 4-cyanophenylaminomethyl, 4-fluorophenylaminomethyl, 4-fluoropyridin-2-ylaminomethyl, 4-hydroxyphenylmethyl, 4-methoxycarbonylmorpholin-3-yl, 4-methoxycarbonylpiperazin-1-ylmethyl, 4-methoxyphenylaminomethyl, 4-methylcarbonyloxyphenylmethyl, 5-fluoropyridin-2-aminomethyl, 5-fluoropyridin-2-oxymethyl, 6-fluoropyridin-3-ylaminomethyl, benzomorpholin-4-ylmethyl, methoxycarbonylaminomethyl, methylmethoxycarbonylaminomethyl, methylphenylaminomethyl, phenylaminomethyl, pyridin-2-oxymethyl, pyridin-2-ylaminomethyl, pyridin-2-yloxymethyl, pyridin-3-oxymethyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl, thiazol-4-ylmethyl, and thien-2-ylmethyl; and R 10 is selected from methyl, hydrogen, fluoro, chloro, and bromo, wherein: when R 1 is cyclopentyl or cyclohexyl, and R 3 is thien-2-ylmethyl, then R 4 is other than thien-2-ylmethyl, 1H-benizimidazol-1-ylmethyl, 1H-indol-3-ylmethyl, or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is hydrogen, and R 3 is 3-fluorophenyl, 3-methylphenyl, or 3-chlorophenyl, then R 4 is other than thien-2-ylmethyl; when R 1 is cyclopentyl, R 10 is methyl and R 3 is 3-fluorophenyl, then R 4 is other than thien-2-ylmethyl or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is fluoro and R 3 is 3-methylphenyl, then R 4 is other than thien-2-ylmethyl or 1H-benzotriazol-1-ylmethyl; when R 1 is cyclopentyl, R 10 is fluoro and R 3 is 3-fluorophenyl, then R 4 is other than thien-2-ylmethyl; when R 1 is cyclohexyl, R 10 is hydrogen, and R 3 is 3-methylphenyl, or 3-chlorophenyl, then R 4 is other than thien-2-ylmethyl; and when R 1 is cyclohexyl, R 10 is hydrogen, and R 3 is 3-fluorophenyl, then R 4 is other than 1H-benzotriazol-1-ylmethyl.