A compound having Formula: or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, or a pharmaceutically acceptable salt thereof, wherein: wherein R 1 is H, F, Cl, Br, I, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, C 1-6 aminoalkoxy, C 1-6 haloalkoxy, C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, or C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m -, wherein each G is O, S, NR 5, C(=O), -C(=O)NH-,-OC(=O)NH-, -OC(=O)- or -NHC(=O)NH-; each p and m is independently 0, 1, 2 or 3; or wherein each of the C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, and C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m - is optionally substituted by one or more F, Cl, Br, I, methyl, ethyl, propyl, cyano, ethynyl, methoxy, ethoxy, or propynyl; R 3 is H, F, Cl, I, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, C 1-6 aminoalkoxy, C 1-6 haloalkoxy, C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, or C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m -, wherein each G is O, S, NR 5, C(=O), -C(=O)NH-,-OC(=O)NH-, -OC(=O)- or -NHC(=O)NH-; each p and m is independently 0, 1, 2 or 3; each R 5 is independently H, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 hydroxyalkyl, C 1-3 aminoalkyl, C 1-3 alkoxy-C 1-3 -alkyl, C 1-3 alkylamino-C 1-3 -alkyl, C 1-3 alkylthio-C 1-3 -alkyl, C 6-10 aryl-C 1-3 -alkyl, C 1-9 heteroaryl-C 1-3 -alkyl, C 2-10 heterocyclyl-C 1-3 -alkyl, C 3-10 cycloalkyl-C 1-3 -alkyl, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; each R 7 is independently H, C 1-6 alkyl, C 1-6 haloaliphatic, C 1-6 hydroxyaliphatic, C 1-6 aminoaliphatic, C 1-6 alkoxy-C 1-6 -aliphatic, C 1-6 alkylamino-C 1-6 -aliphatic, C 1-6 alkylthio-C 1-6 -aliphatic, C 6-10 aryl-C 1-6 -aliphatic, C 1-9 heteroaryl-C 1-6 -aliphatic, C 2-10 heterocyclyl-C 1-6 -aliphatic, C 3-10 cycloalkyl-C 1-6 -aliphatic, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; each R 7a is independently C 1-6 alkyl, C 1-6 haloaliphatic, C 1-6 hydroxyaliphatic, C 1-6 aminoaliphatic, C 1-6 alkoxy-C 1-6 -aliphatic, C 1-6 alkylamino-C 1-6 -aliphatic, C 1-6 alkylthio-C 1-6 -aliphatic, C 6-10 aryl-C 1-6 -aliphatic, C 1-9 heteroaryl-C 1-6 -aliphatic, C 2-10 heterocyclyl-C 1-6 -aliphatic, C 3-10 cycloalkyl-C 1-6 -aliphatic, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; or R 7 and R 7a, together with the nitrogen atom they are attached to, optionally form a substituted or unsubstituted 3-8 membered ring; each R 8a is independently H, hydroxy, amino, F, Cl, Br, I, -N(CH 3) 2, cyano, nitro, mercapto, C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy, C 1-4 alkylamino, C 1-4 alkylthio, C 6-10 aryl, or C 1-9 heteroaryl; and n is 0, 1, 2 or 3. wherein R 1 is H, F, Cl, Br, I, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, C 1-6 aminoalkoxy, C 1-6 haloalkoxy, C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, or C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m -, wherein each G is O, S, NR 5, C(=O), -C(=O)NH-,-OC(=O)NH-, -OC(=O)- or -NHC(=O)NH-; each p and m is independently 0, 1, 2 or 3; or wherein each of the C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, and C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m - is optionally substituted by one or more F, Cl, Br, I, methyl, ethyl, propyl, cyano, ethynyl, methoxy, ethoxy, or propynyl; R 3 is H, F, Cl, I, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, C 1-6 aminoalkoxy, C 1-6 haloalkoxy, C 6-10 aryl-(CH 2) p -G-(CH 2) m -, C 1-9 heteroaryl-(CH 2) p -G-(CH 2) m -, C 2-10 heterocyclyl-(CH 2) p -G-(CH 2) m -, or C 3-10 cycloalkyl-(CH 2) p -G-(CH 2) m -, wherein each G is O, S, NR 5, C(=O), -C(=O)NH-,-OC(=O)NH-, -OC(=O)- or -NHC(=O)NH-; each p and m is independently 0, 1, 2 or 3; each R 5 is independently H, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 hydroxyalkyl, C 1-3 aminoalkyl, C 1-3 alkoxy-C 1-3 -alkyl, C 1-3 alkylamino-C 1-3 -alkyl, C 1-3 alkylthio-C 1-3 -alkyl, C 6-10 aryl-C 1-3 -alkyl, C 1-9 heteroaryl-C 1-3 -alkyl, C 2-10 heterocyclyl-C 1-3 -alkyl, C 3-10 cycloalkyl-C 1-3 -alkyl, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; each R 7 is independently H, C 1-6 alkyl, C 1-6 haloaliphatic, C 1-6 hydroxyaliphatic, C 1-6 aminoaliphatic, C 1-6 alkoxy-C 1-6 -aliphatic, C 1-6 alkylamino-C 1-6 -aliphatic, C 1-6 alkylthio-C 1-6 -aliphatic, C 6-10 aryl-C 1-6 -aliphatic, C 1-9 heteroaryl-C 1-6 -aliphatic, C 2-10 heterocyclyl-C 1-6 -aliphatic, C 3-10 cycloalkyl-C 1-6 -aliphatic, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; each R 7a is independently C 1-6 alkyl, C 1-6 haloaliphatic, C 1-6 hydroxyaliphatic, C 1-6 aminoaliphatic, C 1-6 alkoxy-C 1-6 -aliphatic, C 1-6 alkylamino-C 1-6 -aliphatic, C 1-6 alkylthio-C 1-6 -aliphatic, C 6-10 aryl-C 1-6 -aliphatic, C 1-9 heteroaryl-C 1-6 -aliphatic, C 2-10 heterocyclyl-C 1-6 -aliphatic, C 3-10 cycloalkyl-C 1-6 -aliphatic, C 6-10 aryl, C 1-9 heteroaryl, C 2-10 heterocyclyl or C 3-10 carbocyclyl; or R 7 and R 7a, together with the nitrogen atom they are attached to, optionally form a substituted or unsubstituted 3-8 membered ring; each R 8a is independently H, hydroxy, amino, F, Cl, Br, I, -N(CH 3) 2, cyano, nitro, mercapto, C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy, C 1-4 alkylamino, C 1-4 alkylthio, C 6-10 aryl, or C 1-9 heteroaryl; and n is 0, 1, 2 or 3.