An analyte sensing system for measuring a concentration of an analyte in a mammal over a sensor duration time period, the analyte sensing system comprising: an analyte sensor (10,12) for implantation in a the mammal; and a sensor electronics device (100, 200) in communication with the analyte sensor, the sensor electronics device including circuitry to: calculate the concentration of the analyte by applying cycles wherein each cycle consists of: applying a first electrode potential to an analyte sensor for a first predetermined period of time; applying a second electrode potential to the analyte sensor for a second predetermined period of time; receiving signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; and calculating the concentration of the analyte from the signals received and monitored from the analyte sensor; wherein calculating the concentration of the analyte includes analyzing relaxation kinetics of the signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; wherein the sensor duration time period is greater than 3 hours; wherein the first predetermined period of time is between 1 second and 120 seconds; and the second predetermined period of time is between 1 second and 120 seconds; characterized in that the cycle is continuously repeated over the sensor duration time period. an analyte sensor (10,12) for implantation in a the mammal; and a sensor electronics device (100, 200) in communication with the analyte sensor, the sensor electronics device including circuitry to: calculate the concentration of the analyte by applying cycles wherein each cycle consists of: applying a first electrode potential to an analyte sensor for a first predetermined period of time; applying a second electrode potential to the analyte sensor for a second predetermined period of time; receiving signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; and calculating the concentration of the analyte from the signals received and monitored from the analyte sensor; wherein calculating the concentration of the analyte includes analyzing relaxation kinetics of the signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; wherein the sensor duration time period is greater than 3 hours; wherein the first predetermined period of time is between 1 second and 120 seconds; and the second predetermined period of time is between 1 second and 120 seconds; characterized in that the cycle is continuously repeated over the sensor duration time period. calculate the concentration of the analyte by applying cycles wherein each cycle consists of: applying a first electrode potential to an analyte sensor for a first predetermined period of time; applying a second electrode potential to the analyte sensor for a second predetermined period of time; receiving signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; and calculating the concentration of the analyte from the signals received and monitored from the analyte sensor; wherein calculating the concentration of the analyte includes analyzing relaxation kinetics of the signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; wherein the sensor duration time period is greater than 3 hours; wherein the first predetermined period of time is between 1 second and 120 seconds; and the second predetermined period of time is between 1 second and 120 seconds; characterized in that the cycle is continuously repeated over the sensor duration time period. applying a first electrode potential to an analyte sensor for a first predetermined period of time; applying a second electrode potential to the analyte sensor for a second predetermined period of time; receiving signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; and calculating the concentration of the analyte from the signals received and monitored from the analyte sensor; wherein calculating the concentration of the analyte includes analyzing relaxation kinetics of the signals from the analyte sensor during the first predetermined period of time and the second predetermined period of time; wherein the sensor duration time period is greater than 3 hours; wherein the first predetermined period of time is between 1 second and 120 seconds; and the second predetermined period of time is between 1 second and 120 seconds; characterized in that the cycle is continuously repeated over the sensor duration time period.