A bone fixation system, comprising: a bone plate having a body that defines an interior surface that defines at least one hole that defines a central axis, the interior surface defining plate threads; and a bone screw having a head and a shaft extending from the head along a central axis of the bone screw, the head having an exterior surface that defines head threads that are configured to threadedly engage the plate threads, wherein the plate threads and the head threads each have a cross-sectional profile in a respective reference plane extending along the respective central axis, the cross-sectional profiles each comprising: roots (58, 78); crests (56, 76); and flanks (55, 57, 75, 77) extending from the roots (58, 78) toward the crests (56, 76), wherein the roots (58, 78), crests (56, 76), and flanks (55, 57, 75, 77) collectively deviate from a reference cross-sectional profile that is V-shaped in the respective reference plane and defines crest reference points (56-3, 76-4) at apices at a first side thereof and root reference points (58-2, 78-2) at apices at a second side thereof opposite the first side, such that a thread height (H1, H3) measured from the crests (56, 76) to the roots (58, 78) is less than a reference height (H2, H4) measured from the crest reference points (56-3, 76-4) to the root reference points (58-2, 78-2), wherein a first ratio (HF-S) of the thread height of the head threads to the reference height of the head threads is in a range of 0.50:1 to 0.80:1, and a second ratio (HF-P) of the thread height of the plate threads to the reference height of the plate threads is in a range of 0.50:1 to 0.75:1. a bone plate having a body that defines an interior surface that defines at least one hole that defines a central axis, the interior surface defining plate threads; and a bone screw having a head and a shaft extending from the head along a central axis of the bone screw, the head having an exterior surface that defines head threads that are configured to threadedly engage the plate threads, wherein the plate threads and the head threads each have a cross-sectional profile in a respective reference plane extending along the respective central axis, the cross-sectional profiles each comprising: roots (58, 78); crests (56, 76); and flanks (55, 57, 75, 77) extending from the roots (58, 78) toward the crests (56, 76), wherein the roots (58, 78), crests (56, 76), and flanks (55, 57, 75, 77) collectively deviate from a reference cross-sectional profile that is V-shaped in the respective reference plane and defines crest reference points (56-3, 76-4) at apices at a first side thereof and root reference points (58-2, 78-2) at apices at a second side thereof opposite the first side, such that a thread height (H1, H3) measured from the crests (56, 76) to the roots (58, 78) is less than a reference height (H2, H4) measured from the crest reference points (56-3, 76-4) to the root reference points (58-2, 78-2), wherein a first ratio (HF-S) of the thread height of the head threads to the reference height of the head threads is in a range of 0.50:1 to 0.80:1, and a second ratio (HF-P) of the thread height of the plate threads to the reference height of the plate threads is in a range of 0.50:1 to 0.75:1. roots (58, 78); crests (56, 76); and flanks (55, 57, 75, 77) extending from the roots (58, 78) toward the crests (56, 76), wherein the roots (58, 78), crests (56, 76), and flanks (55, 57, 75, 77) collectively deviate from a reference cross-sectional profile that is V-shaped in the respective reference plane and defines crest reference points (56-3, 76-4) at apices at a first side thereof and root reference points (58-2, 78-2) at apices at a second side thereof opposite the first side, such that a thread height (H1, H3) measured from the crests (56, 76) to the roots (58, 78) is less than a reference height (H2, H4) measured from the crest reference points (56-3, 76-4) to the root reference points (58-2, 78-2), wherein a first ratio (HF-S) of the thread height of the head threads to the reference height of the head threads is in a range of 0.50:1 to 0.80:1, and a second ratio (HF-P) of the thread height of the plate threads to the reference height of the plate threads is in a range of 0.50:1 to 0.75:1.