A tool for at least one of monitoring and altering electrophysiological activity within the vicinity of a lumen within a body, comprising: an elongate member with a distal tip and a control end, the distal tip thereof shaped and dimensioned so as to fit within the lumen, the elongate member shaped and dimensioned so as to extend from an entry site on the body into the lumen; and one or more probes (114a-f) each configured with a probe tip, the probes deploy-ably coupled with the distal tip of the elongate member and at least one of electrically, mechanically, and fluidly coupled to the control end of the elongate member, the probe tips (114a-f) shaped so as to at least one of penetrate into and penetrate through a wall of the lumen upon deployment from the elongate member, one or more of the probes (114a-f) comprising a plurality of electrodes electrically coupled to the one or more probes (114a-f), one or more of the electrodes configured to at least one of convey a signal associated with an electrophysiological activity and alter the electrophysiological activity upon deployment; and a controller (190, 191), the controller configured: to record one or more electrophysiological signals from monitored electrophysiological activity within the vicinity of one or more of the electrodes coupled to the probes (114a-f); characterized in that the controller is further configured to cancel one or more movement artifacts from the recorded electrophysiological signals utilizing a corrective signal, the corrective signal being generated from monitoring a physiological parameter of the subject at a location remote from the vicinity of the one or more electrodes coupled to the probes (114a-f). an elongate member with a distal tip and a control end, the distal tip thereof shaped and dimensioned so as to fit within the lumen, the elongate member shaped and dimensioned so as to extend from an entry site on the body into the lumen; and one or more probes (114a-f) each configured with a probe tip, the probes deploy-ably coupled with the distal tip of the elongate member and at least one of electrically, mechanically, and fluidly coupled to the control end of the elongate member, the probe tips (114a-f) shaped so as to at least one of penetrate into and penetrate through a wall of the lumen upon deployment from the elongate member, one or more of the probes (114a-f) comprising a plurality of electrodes electrically coupled to the one or more probes (114a-f), one or more of the electrodes configured to at least one of convey a signal associated with an electrophysiological activity and alter the electrophysiological activity upon deployment; and a controller (190, 191), the controller configured: to record one or more electrophysiological signals from monitored electrophysiological activity within the vicinity of one or more of the electrodes coupled to the probes (114a-f); characterized in that the controller is further configured to cancel one or more movement artifacts from the recorded electrophysiological signals utilizing a corrective signal, the corrective signal being generated from monitoring a physiological parameter of the subject at a location remote from the vicinity of the one or more electrodes coupled to the probes (114a-f). to record one or more electrophysiological signals from monitored electrophysiological activity within the vicinity of one or more of the electrodes coupled to the probes (114a-f); characterized in that the controller is further configured to cancel one or more movement artifacts from the recorded electrophysiological signals utilizing a corrective signal, the corrective signal being generated from monitoring a physiological parameter of the subject at a location remote from the vicinity of the one or more electrodes coupled to the probes (114a-f).