A method used to handle piece goods being moved one after another, with the piece goods being transported to a seizing range of at least one manipulator, wherein - a transported piece good or a group comprising at least two transported piece goods is seized in the seizing range by means of clamping means and/or gripping means of the at least one manipulator, is spatially separated from subsequent piece goods, and is brought into a defined relative target position and target alignment in relation to the in each instance subsequent piece goods by means of a rotational movement of the manipulator, characterised in that - a first vertical symmetry plane, which is defined by the seized piece good or the seized group, and which is oriented approximately perpendicular to a transport direction of the piece goods, is spaced apart from a second vertical symmetry plane aligned approximately parallel thereto, with the second vertical symmetry plane being defined by the manipulator or by the manipulator clamping means and/or gripping means, as applicable; and in that - one transported piece good or one group is in each instance seized in at least one step of a plurality of temporally consecutive steps and is in each instance spatially separated from a straight movement path in the original transport direction by means of a rotation of the manipulator or of the manipulator clamping means and/or gripping means, as applicable, by a rotation angle of approximately 270° about a vertical axis and is brought into a particular defined relative target position and target alignment in relation to subsequent piece goods, - with the result that a palletizable layer or a pre-group for a palletizable layer is formed from the piece goods that have been brought and rotated in temporally consecutive steps into their particular target position and target alignment. - a transported piece good or a group comprising at least two transported piece goods is seized in the seizing range by means of clamping means and/or gripping means of the at least one manipulator, is spatially separated from subsequent piece goods, and is brought into a defined relative target position and target alignment in relation to the in each instance subsequent piece goods by means of a rotational movement of the manipulator, characterised in that - a first vertical symmetry plane, which is defined by the seized piece good or the seized group, and which is oriented approximately perpendicular to a transport direction of the piece goods, is spaced apart from a second vertical symmetry plane aligned approximately parallel thereto, with the second vertical symmetry plane being defined by the manipulator or by the manipulator clamping means and/or gripping means, as applicable; and in that - one transported piece good or one group is in each instance seized in at least one step of a plurality of temporally consecutive steps and is in each instance spatially separated from a straight movement path in the original transport direction by means of a rotation of the manipulator or of the manipulator clamping means and/or gripping means, as applicable, by a rotation angle of approximately 270° about a vertical axis and is brought into a particular defined relative target position and target alignment in relation to subsequent piece goods, - with the result that a palletizable layer or a pre-group for a palletizable layer is formed from the piece goods that have been brought and rotated in temporally consecutive steps into their particular target position and target alignment.