A compound of Formula: or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein: X 1, X 2, X 3, and X 4 are independently CR 6; or X 1, X 2 and X 3 are CR 6 and X 4 is N; or X 2 and X 3 are CR 6 and X 1 and X 4 are N; the moiety is independently * denotes the attachment point to L; L is independently a covalent bond or -CH 2 -; W is independently O or -OCH 2 -; the moiety is independently -NR 7 R 4b, or R 1 is CO 2 H; R 2 is each independently halo, cyano, hydroxyl, C 1-4 alkoxy, C 1-4 haloalkyl or C 1-4 haloalkoxy; R 3a is independently hydrogen, halo, hydroxyl, or C 1-4 alkyl; R 3b is independently hydrogen, halo, cyano, hydroxyl, amino, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy or C 1-6 alkyl substituted with 0 to 2 R a; or alternatively, R 3a and R 3b together, with the carbon atom they are attached to, form a C 3-4 carbocyclyl; R 4 is independently C 3-6 alkyl, -(CH 2) 0-1 -C 3-6 cycloalkyl, -(CH(C 1-2 alkyl))-C 3-6 cycloalkyl, -(CH 2) 0-1 -phenyl or -(CH(C 1-2 alkyl))-phenyl, wherein each of said cycloalkyl and phenyl is independently substituted with 0 to 3 R 10; R 4b is independently 5 to 6-membered heteroaryl substituted with 0 to 2 R 10a; R 5a is independently C 1-6 alkyl, or -(CH 2) 0-1 -(C 3-6 cycloalkyl); R 5b is independently hydrogen, halo, cyano, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, or -(CH 2) 0-1 -(C 3-6 cycloalkyl); R 6 is each independently hydrogen, halo, hydroxyl, C 1-6 alkyl, C 1-4 haloalkyl, or C 1-4 alkoxy; R 7 is hydrogen or C 1-2 alkyl; R 10 is each independently halo, cyano, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, or C 1-6 haloalkoxy; R 10a is each independently halo, cyano, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -(CH 2) 0-3 -C 3-6 cycloalkyl, phenyl or 5 to 6 membered heteroaryl; R a is independently halo, cyano, hydroxyl, C 1-4 alkoxy, C 1-4 haloalkyl, or C 1-4 haloalkoxy; m is 0 or 1; and q is 0 or 1. X 1, X 2, X 3, and X 4 are independently CR 6; or X 1, X 2 and X 3 are CR 6 and X 4 is N; or X 2 and X 3 are CR 6 and X 1 and X 4 are N; the moiety is independently * denotes the attachment point to L; L is independently a covalent bond or -CH 2 -; W is independently O or -OCH 2 -; the moiety is independently -NR 7 R 4b, or R 1 is CO 2 H; R 2 is each independently halo, cyano, hydroxyl, C 1-4 alkoxy, C 1-4 haloalkyl or C 1-4 haloalkoxy; R 3a is independently hydrogen, halo, hydroxyl, or C 1-4 alkyl; R 3b is independently hydrogen, halo, cyano, hydroxyl, amino, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy or C 1-6 alkyl substituted with 0 to 2 R a; or alternatively, R 3a and R 3b together, with the carbon atom they are attached to, form a C 3-4 carbocyclyl; R 4 is independently C 3-6 alkyl, -(CH 2) 0-1 -C 3-6 cycloalkyl, -(CH(C 1-2 alkyl))-C 3-6 cycloalkyl, -(CH 2) 0-1 -phenyl or -(CH(C 1-2 alkyl))-phenyl, wherein each of said cycloalkyl and phenyl is independently substituted with 0 to 3 R 10; R 4b is independently 5 to 6-membered heteroaryl substituted with 0 to 2 R 10a; R 5a is independently C 1-6 alkyl, or -(CH 2) 0-1 -(C 3-6 cycloalkyl); R 5b is independently hydrogen, halo, cyano, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, or -(CH 2) 0-1 -(C 3-6 cycloalkyl); R 6 is each independently hydrogen, halo, hydroxyl, C 1-6 alkyl, C 1-4 haloalkyl, or C 1-4 alkoxy; R 7 is hydrogen or C 1-2 alkyl; R 10 is each independently halo, cyano, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, or C 1-6 haloalkoxy; R 10a is each independently halo, cyano, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -(CH 2) 0-3 -C 3-6 cycloalkyl, phenyl or 5 to 6 membered heteroaryl; R a is independently halo, cyano, hydroxyl, C 1-4 alkoxy, C 1-4 haloalkyl, or C 1-4 haloalkoxy; m is 0 or 1; and q is 0 or 1.