A spinal implant comprising: an interbody cage extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface, the interbody cage further including an inner surface that defines a first hole and a second hole each oriented to implant a respective fastener (42a, 42b) oblique relative to coronal plane CP and to lateral axis XL that lies in the coronal plane and designed to be adjacent an intervertebral space of the subject body and the interbody cage further including an oblique surface, wherein the oblique surface includes a first flange that is designed to engage the first vertebra and defines a first opening disposed in communication and in substantial alignment with the first hole and configured to guide a fastener into the first hole, and a second flange that is designed to engage the second vertebra and defines a second opening disposed in communication and in substantial alignment with the second hole and configured to guide a fastener into the second hole, wherein the first and second holes (224, 226) are disposed at an angular orientation such that the respective fastener (42a, 42b) is delivered to the intervertebral space via a surgical pathway and oriented to penetrate endplate tissue of a respective endplate (E1, E2) of adjacent vertebral endplates (E1, E2) of first and second vertebrae (V1, V2) of the subject body, and wherein the first flange defines a first outer hole and the second flange defines a second outer hole, the outer holes being defined and oriented to guide other fasteners (42c, 42d) into side walls of the adjacent vertebrae (V1, V2). an interbody cage extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface, the interbody cage further including an inner surface that defines a first hole and a second hole each oriented to implant a respective fastener (42a, 42b) oblique relative to coronal plane CP and to lateral axis XL that lies in the coronal plane and designed to be adjacent an intervertebral space of the subject body and the interbody cage further including an oblique surface, wherein the oblique surface includes a first flange that is designed to engage the first vertebra and defines a first opening disposed in communication and in substantial alignment with the first hole and configured to guide a fastener into the first hole, and a second flange that is designed to engage the second vertebra and defines a second opening disposed in communication and in substantial alignment with the second hole and configured to guide a fastener into the second hole, wherein the first and second holes (224, 226) are disposed at an angular orientation such that the respective fastener (42a, 42b) is delivered to the intervertebral space via a surgical pathway and oriented to penetrate endplate tissue of a respective endplate (E1, E2) of adjacent vertebral endplates (E1, E2) of first and second vertebrae (V1, V2) of the subject body, and wherein the first flange defines a first outer hole and the second flange defines a second outer hole, the outer holes being defined and oriented to guide other fasteners (42c, 42d) into side walls of the adjacent vertebrae (V1, V2).