mhurhangee/ep-ind-claims huggingface dataset:
A dual-drug conjugate comprising a structure of Formula I or a pharmaceutically acceptable salt thereof, wherein: A is a targeting protein; each D 1 may be independently selected, where each D 1 includes an active agent; each L 1 is independently a linker including at least one N (nitrogen) atom and comprises each D 2 is independently selected, where each D 2 includes an active agent, wherein D 1 and D 2 are different active agents; each L 2 is independently a linker; the E -component is an optionally substituted heteroaryl wherein the E -component includes a fragment selected from the group consisting of: each L 3 is an optionally substituted C 1 -C 6 alkyl, or each L 3 is null, when L 3 is null the sulfur is directly connected to the E -component; and each L 4 is an optionally substituted C 1 -C 6 alkyl, or each L 4 is null, when L 4 is null the sulfur is directly connected to the E -component; m is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10. A is a targeting protein; each D 1 may be independently selected, where each D 1 includes an active agent; each L 1 is independently a linker including at least one N (nitrogen) atom and comprises each D 2 is independently selected, where each D 2 includes an active agent, wherein D 1 and D 2 are different active agents; each L 2 is independently a linker; the E -component is an optionally substituted heteroaryl wherein the E -component includes a fragment selected from the group consisting of: each L 3 is an optionally substituted C 1 -C 6 alkyl, or each L 3 is null, when L 3 is null the sulfur is directly connected to the E -component; and each L 4 is an optionally substituted C 1 -C 6 alkyl, or each L 4 is null, when L 4 is null the sulfur is directly connected to the E -component; m is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.
A method comprising: causing transmission of at least one signal to at least one wearable device, separate from an autonomous or semi-autonomous vehicle, to control feedback provided to at least one passenger of the autonomous or semi-autonomous vehicle by the at least one wearable device 1 so as to provide control information of the autonomous or semi-autonomous vehicle, wherein the feedback comprises tactile feedback.
An electronic injection monitoring device configured to mate with a syringe having a flange, comprising: a channel configured to receive at least a portion of the syringe; one or more flange members (107A, 107B) configured to couple to the flange of the syringe and to be gripped during performance of an injection; one or more force sensors (146A, 146B) connected to the flange members (107A, 107B), wherein the one or more force sensors are oriented to detect data associated with an amount of force applied to an underside of the injection monitoring device during performance of an injection; a communication module configured to transmit data from the force sensors (146A, 146B) to an external device; a sensor configured to detect deployment of a safety shield of the syringe, wherein the sensor is a switch configured to activate in response to movement of a housing member of the syringe during deployment of the safety shield. a channel configured to receive at least a portion of the syringe; one or more flange members (107A, 107B) configured to couple to the flange of the syringe and to be gripped during performance of an injection; one or more force sensors (146A, 146B) connected to the flange members (107A, 107B), wherein the one or more force sensors are oriented to detect data associated with an amount of force applied to an underside of the injection monitoring device during performance of an injection; a communication module configured to transmit data from the force sensors (146A, 146B) to an external device; a sensor configured to detect deployment of a safety shield of the syringe, wherein the sensor is a switch configured to activate in response to movement of a housing member of the syringe during deployment of the safety shield.
Device for actuating a lock integrated in a door, hatch or similar, especially in a vehicle, featuring a manually operable handle on the outside of the door, which has a bearing lug with bearing points at one end of its handle, with a carrier fixed inside the door featuring counter-bearing points for the bearing points of the handle, with a two-part electrical control (41, 42) for the lock, with its one control part integrated in the handle and connected via an electrical line (61, 62) with the other remaining control part located in the vehicle, with a two-part electrical coupling located between two line sections (61, 62) of the electric line, consisting of a coupling part connected to the handle-side control part via a line section and one counter-coupling part connected to the vehicle-side control remainder part via a line section, wherein the mating coupling part can be coupled into the coupling part which is received in the bearing lug by the handle, wherein the handle with its bearing lug can be inserted from the outside of the door through an opening in the outer lining of the door and is mountable (25, 26) inside the door with its bearing points in the counter-bearing points of the carrier, whereby the bearing and counter-bearing points (23, 13) determine a swivel axis in the carrier for operating the handle, characterised in that, the bearing lug has a receptacle for its electrical coupling part from the handle, the counter-coupling part protrudes with its line section out of the opening in the door outer panel, so that without a handle mounting (25, 26) on the carrier the counter-coupling part can be manually coupled with the coupling part located in the handle-side receptacle and the coupling part arranged in the handle engages with the coupling part coupled with the counter-coupling part to form a fixed, jointly movable physical unit outside of the carrier, the receptacle on the one hand and the coupling part on the other hand have two mutually complementary elements (17, 18) of a latching closure latched together with an inserted coupling part and secure the insertion position of the coupling part in the handle, in the position of use, the swivel axis of the handle at the same time constitutes the axis of rotation for the two electrically coupled coupling and counter-coupling parts (52, 51).
Apparatus for measuring a colour parameter of a gemstone, comprising: a support structure for supporting the gemstone at a measurement location; an illumination system (201,202,203,204) for illuminating the gemstone at the measurement location; an imaging device directed towards the measurement location for obtaining an image of the gemstone; and an image processor for analysing the image of the gemstone, the image processor configured to: identify a set of stone pixels corresponding to the gemstone in the image; and identify luminance and chrominance values for each stone pixel; and characterised in that the image processor is further configured to: calculate a colour vector (401,402) from an expression of the chrominance values of the stone pixels in chrominance space, the colour vector extending in chrominance space from stone pixels having a relatively high luminance value to stone pixels having a relatively low luminance value; and determine the colour parameter using a direction of the colour vector. a support structure for supporting the gemstone at a measurement location; an illumination system (201,202,203,204) for illuminating the gemstone at the measurement location; an imaging device directed towards the measurement location for obtaining an image of the gemstone; and an image processor for analysing the image of the gemstone, the image processor configured to: identify a set of stone pixels corresponding to the gemstone in the image; and identify luminance and chrominance values for each stone pixel; identify a set of stone pixels corresponding to the gemstone in the image; and identify luminance and chrominance values for each stone pixel; and characterised in that the image processor is further configured to: calculate a colour vector (401,402) from an expression of the chrominance values of the stone pixels in chrominance space, the colour vector extending in chrominance space from stone pixels having a relatively high luminance value to stone pixels having a relatively low luminance value; and determine the colour parameter using a direction of the colour vector. calculate a colour vector (401,402) from an expression of the chrominance values of the stone pixels in chrominance space, the colour vector extending in chrominance space from stone pixels having a relatively high luminance value to stone pixels having a relatively low luminance value; and determine the colour parameter using a direction of the colour vector.
A method for generating, at a mobile station, a short-term key for viewing content at the mobile station in a communication system for point-to-multipoint transmission of content to mobile stations, the method comprising: receiving at the mobile station, a first value and a first message authentication code from a short-term key manager of the system; generating a second message authentication code as a function of the first value by running a hashing function on the received first value using a second value comprising a Broadcast Access Key or a derivative of a Broadcast Access Key, the second value being stored in a secure memory of the mobile station; comparing the second message authentication code with the received first message authentication code; and characterized by: computing the short-term key using the first value and the second value provided that the second message authentication code is equal to the first message authentication code. receiving at the mobile station, a first value and a first message authentication code from a short-term key manager of the system; generating a second message authentication code as a function of the first value by running a hashing function on the received first value using a second value comprising a Broadcast Access Key or a derivative of a Broadcast Access Key, the second value being stored in a secure memory of the mobile station; comparing the second message authentication code with the received first message authentication code; and characterized by: computing the short-term key using the first value and the second value provided that the second message authentication code is equal to the first message authentication code. computing the short-term key using the first value and the second value provided that the second message authentication code is equal to the first message authentication code.
A system arrangement for fault-tolerant control of a plurality of execution units of the system arrangement, comprising: - a command unit and line driver units, wherein - the plurality of execution units is segmented into a plurality of respective serial sub-chains, each sub-chain having at least one execution unit along a first data line, and a line driver unit is connected upstream of each sub-chain; and - the line driver units are serially communicatively coupled to one another by means of a second data line and the first series-connected line driver unit is communicatively coupled to the command unit by means of the second data line, characterised in that in that the system arrangement is set up to modulate signals on the second data line with an amplitude 10 times greater than signals on the first data line, the system arrangement furthermore being set up to always provide differential modulation when the plurality of execution units are actuated, so that the data lines are actively controlled even if no command is transmitted. - a command unit and line driver units, wherein - the plurality of execution units is segmented into a plurality of respective serial sub-chains, each sub-chain having at least one execution unit along a first data line, and a line driver unit is connected upstream of each sub-chain; and - the line driver units are serially communicatively coupled to one another by means of a second data line and the first series-connected line driver unit is communicatively coupled to the command unit by means of the second data line, characterised in that in that the system arrangement is set up to modulate signals on the second data line with an amplitude 10 times greater than signals on the first data line, the system arrangement furthermore being set up to always provide differential modulation when the plurality of execution units are actuated, so that the data lines are actively controlled even if no command is transmitted.
A method for rating media content on a wireless communication device, comprising: creating, by the user, a priority list providing an indication of an order in which media content is acquired; changing, by the user, the order of a media content in the priority list; acquiring the media content on the wireless communication device according to the priority list; playing one or more portions of the media content on the wireless communication device, wherein a portion is any segment of the media content less than the entire media content; logging an amount of the playing of one or more portions of the media content wherein the amount includes a number of times or duration of play of the one or more portions of the media content; and automatically rating, at the wireless communication device, the media content based on the logged amount of playing of each portion and the amount of change of the order of the acquisition priority of the media content in said priority list. creating, by the user, a priority list providing an indication of an order in which media content is acquired; changing, by the user, the order of a media content in the priority list; acquiring the media content on the wireless communication device according to the priority list; playing one or more portions of the media content on the wireless communication device, wherein a portion is any segment of the media content less than the entire media content; logging an amount of the playing of one or more portions of the media content wherein the amount includes a number of times or duration of play of the one or more portions of the media content; and automatically rating, at the wireless communication device, the media content based on the logged amount of playing of each portion and the amount of change of the order of the acquisition priority of the media content in said priority list.
A dual clutch engaging/disengaging mechanism in which an output shaft connected to an odd-numbered gear set and an output shaft connected to an even-numbered gear set are coaxially placed, and transmission of power is switched over with respect to these two output shafts, wherein one of the two output shafts which is located on an inner side is a first shaft, and the other output shaft which is located on an outer side is a second shaft, the first shaft projecting more than the second shaft, a first clutch disk is connected to a projecting portion of the first shaft, a second clutch disk is connected to the second shaft, characterized in that the second clutch disk is connected to the second shaft through a sleeve, the sleeve is coupled in a state where the sleeve is fixed to the second shaft in a rotation direction and the sleeve can relatively move with respect to the second shaft in an axial direction of the engaging/disengaging mechanism, the second clutch disk is coupled in a state where the second clutch disk is fixed to the sleeve in the rotation direction and the second clutch disk can relatively move with respect to the sleeve in the axial direction, and a pressurizing member for pressing the first clutch disk is connected to one end of the sleeve, and an actuator is connected to the other end of the sleeve.
Connection part made of composite material, intended to create a connection between a first mechanical part and a second mechanical part, said connection part being thermohardenable and partially polymerised in such a way as to be rigid at ambient temperature and capable of being subjected to a final later polymerisation, said connection part being provided, at a second end intended for the connection to the second mechanical part, with a housing, characterised in that it includes a ball mounted in the housing.
A scanning device of a laser light beam (7,8) for reading coded information, comprising: ∘ an emission source of a laser light beam (7,8), the laser light beam defining an optical path (10a,10b); ∘ an optical element for scanning the laser light beam on a support containing coded information; ∘ a linear polarizer located along the optical path (10a,10b) of said laser light beam (7,8), upstream the optical element for scanning, said polarizer being apt to linearly polarize a first portion of said laser light beam in substantially one first plane (s) and direct said polarized portion only towards said optical element for scanning; ∘ characterized in that it comprises a further emission source of a further laser light beam (7,8) which defines a further optical path (10a,10b), said optical path of said laser light beam and said further optical path of said further optical laser light beam being substantially parallel, wherein said linear polarizer is located along the optical path of said laser light beam and along the further optical path of said further laser light beam and upstream the optical element for scanning in the propagation direction of the laser light beam and the further laser light beam. ∘ an emission source of a laser light beam (7,8), the laser light beam defining an optical path (10a,10b); ∘ an optical element for scanning the laser light beam on a support containing coded information; ∘ a linear polarizer located along the optical path (10a,10b) of said laser light beam (7,8), upstream the optical element for scanning, said polarizer being apt to linearly polarize a first portion of said laser light beam in substantially one first plane (s) and direct said polarized portion only towards said optical element for scanning; ∘ characterized in that it comprises a further emission source of a further laser light beam (7,8) which defines a further optical path (10a,10b), said optical path of said laser light beam and said further optical path of said further optical laser light beam being substantially parallel, wherein said linear polarizer is located along the optical path of said laser light beam and along the further optical path of said further laser light beam and upstream the optical element for scanning in the propagation direction of the laser light beam and the further laser light beam.
Household appliance with an operating panel and a rotary knob for actuating a regulation facility of the household appliance, wherein the operating panel has an aperture, into which a guide section of a rotary knob can be introduced, wherein the guide section comprises radial guide elements for radially guiding the guide section on a cylindrical outer wall of the aperture and axial guide elements for axially guiding the rotary knob on the operating panel, wherein each radial guide element has a sliding surface which is configured to slide on the outer wall of the aperture, wherein each axial guide element has a latching hook which is configured to latch the rotary knob on the operating panel, wherein there is provision on the operating panel for an annular recess running around the aperture, into which the latching hook can be snapped into place, and wherein end faces of the latching hooks are configured to slide on a base surface of the recess.
Machine direction oriented multilayer film suitable for labels comprising a core layer and two outer layers (O-1, O-2) sandwiching the core layer, wherein (i) the core layer comprises a bimodal ethylene/1-butene/C 6 -C 12 -alpha-olefin terpolymer, with a density between 926 kg/m 3 to 950 kg/m 3 and (ii) the two outer layers comprising unimodal HDPE with a density of more than 940 kg/m 3 up to 970 kg/m 3. (i) the core layer comprises a bimodal ethylene/1-butene/C 6 -C 12 -alpha-olefin terpolymer, with a density between 926 kg/m 3 to 950 kg/m 3 and (ii) the two outer layers comprising unimodal HDPE with a density of more than 940 kg/m 3 up to 970 kg/m 3.
A process for preparing a coatings composition with an open time additive comprising the steps of a) contacting an aqueous dispersion of alkali swellable polymer particles with a rheology modifier and a binder to form a coatings composition with a VOC of less than 50 g/L; and b) neutralizing the alkali swellable particles with a non-volatile base after or upon contact with the rheology modifier and the binder to form swelled multi-staged polymer particles; wherein the alkali swellable polymer particles comprise a shell having a T g of not greater than 25 °C and an acid functionalized core; and wherein the core-to-shell ratio is in the range of from 1:3.2 to 1: 10; wherein the acid functionalized core of the alkali swellable polymer particles comprises from 30 to 50 weight percent structural units of a carboxylic acid monomer, and from 50 to 70 weight percent structural units of a nonionic ethylenically unsaturated monomer, based on the weight of the core; and further wherein the terms "core" and "shell" herein describe the first and final stages of the multi-staged polymerization process. wherein the acid functionalized core of the alkali swellable polymer particles comprises from 30 to 50 weight percent structural units of a carboxylic acid monomer, and from 50 to 70 weight percent structural units of a nonionic ethylenically unsaturated monomer, based on the weight of the core; and further wherein the terms "core" and "shell" herein describe the first and final stages of the multi-staged polymerization process.
A method of diagnosing tuberculosis disease in a subject, the method comprising the steps of: a) testing a blood sample from a subject suspected of having TB for the presence of neural cell adhesion molecule (NCAM/ CD56); and b) diagnosing the patient as having TB if a reduced level of NCAM is detected in the sample relative to a level of NCAM which is associated with subjects with upper and lower respiratory tract infections, chronic obstructive pulmonary disease and asthma. a) testing a blood sample from a subject suspected of having TB for the presence of neural cell adhesion molecule (NCAM/ CD56); and b) diagnosing the patient as having TB if a reduced level of NCAM is detected in the sample relative to a level of NCAM which is associated with subjects with upper and lower respiratory tract infections, chronic obstructive pulmonary disease and asthma.
An implantable medical device comprising: therapy delivery circuitry configured to deliver anti-tachycardia pacing therapy to a heart of a patient, the ATP therapy including one or more pulse trains, each of the one or more pulse trains including a plurality of pacing pulses; and processing circuitry configured to: for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse; and modify the ATP therapy based on the at least one latency metric. therapy delivery circuitry configured to deliver anti-tachycardia pacing therapy to a heart of a patient, the ATP therapy including one or more pulse trains, each of the one or more pulse trains including a plurality of pacing pulses; and processing circuitry configured to: for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse; and modify the ATP therapy based on the at least one latency metric. for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse; and modify the ATP therapy based on the at least one latency metric.