Electrical stimulation and monitoring device comprising: - a semiconductor substrate of a first conduction type, provided with a set of separated wells (10, 20, 30) all having a second conduction type, said first and second conduction types being opposite so that each well forms a respective embedded diode at a boundary between said well and a bulk portion of the substrate having the first conductivity type; - a set of capacitor structures (C1, C2, C3) which are each accommodated within one of the wells (10, 20, 30) separately from the other capacitor structures, each capacitor structure having a first electrode (11, 21, 31), a second electrode (12, 22, 32) and a layer portion of an electrically insulating material, the first electrode being formed by the well which is dedicated to said capacitor structure, and the layer portion of insulating material being arranged between the first and second electrodes; - a set of stimulation or sensing electrodes (25, 35) which are each connected to the first electrode (21, 31) of one of the capacitor structures (C2, C3); and - a set of stimulation or sensing channels (26, 36) which are each connected to the second electrode (22, 32) of one of the capacitor structures (C2, C3), and each comprising a current source for injecting a stimulation current into one of the stimulation or sensing electrodes through one of the capacitor structures which is connected serially between the stimulation or sensing channel and the stimulation or sensing electrode (25, 35), or comprising a sensing circuit for allowing monitoring of a voltage response collected by one of the stimulation or sensing electrodes, and detected by said sensing circuit through the capacitor structure which is connected serially between the stimulation or sensing electrode and the stimulation or sensing channel; wherein the device further comprises a capacitor, called substrate holding capacitor, which has a first electrode electrically connected to the substrate bulk portion, and a second electrode electrically connected for receiving a reference DC voltage set with respect to a first terminal common to the stimulation or sensing channels (26, 36), and also common to a reference electrode intended to be applied on a medium to be analyzed through electrical stimulation and monitoring, when the stimulation or sensing electrodes are also applied to said medium. - a semiconductor substrate of a first conduction type, provided with a set of separated wells (10, 20, 30) all having a second conduction type, said first and second conduction types being opposite so that each well forms a respective embedded diode at a boundary between said well and a bulk portion of the substrate having the first conductivity type; - a set of capacitor structures (C1, C2, C3) which are each accommodated within one of the wells (10, 20, 30) separately from the other capacitor structures, each capacitor structure having a first electrode (11, 21, 31), a second electrode (12, 22, 32) and a layer portion of an electrically insulating material, the first electrode being formed by the well which is dedicated to said capacitor structure, and the layer portion of insulating material being arranged between the first and second electrodes; - a set of stimulation or sensing electrodes (25, 35) which are each connected to the first electrode (21, 31) of one of the capacitor structures (C2, C3); and - a set of stimulation or sensing channels (26, 36) which are each connected to the second electrode (22, 32) of one of the capacitor structures (C2, C3), and each comprising a current source for injecting a stimulation current into one of the stimulation or sensing electrodes through one of the capacitor structures which is connected serially between the stimulation or sensing channel and the stimulation or sensing electrode (25, 35), or comprising a sensing circuit for allowing monitoring of a voltage response collected by one of the stimulation or sensing electrodes, and detected by said sensing circuit through the capacitor structure which is connected serially between the stimulation or sensing electrode and the stimulation or sensing channel;