An isolated monoclonal antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment specifically binds human c-Met protein, said antibody or antigen binding fragment comprising a heavy chain variable domain comprising CDR3, CDR2 and CDR1 and a light chain variable domain comprising CDR3, CDR2 and CDR1, wherein: the variable heavy chain CDR3 sequence is SEQ ID NO:21; the variable heavy chain CDR2 sequence is selected from the group consisting of SEQ ID NO:20, SEQ ID NO:83 and SEQ ID NO:84; and the variable heavy chain CDR1 sequence is SEQ ID NO:19; and the light chain variable domain includes a combination of CDRs selected from the following: (i) the variable light chain CDR3 sequence is SEQ ID NO:33; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (ii) the variable light chain CDR3 sequence is SEQ ID NO:145; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (iii) the variable light chain CDR3 sequence is SEQ ID NO:146; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (iv) the variable light chain CDR3 sequence is SEQ ID NO:147; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (v) the variable light chain CDR3 sequence is SEQ ID NO:148; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144. the variable heavy chain CDR3 sequence is SEQ ID NO:21; the variable heavy chain CDR2 sequence is selected from the group consisting of SEQ ID NO:20, SEQ ID NO:83 and SEQ ID NO:84; and the variable heavy chain CDR1 sequence is SEQ ID NO:19; and the light chain variable domain includes a combination of CDRs selected from the following: (i) the variable light chain CDR3 sequence is SEQ ID NO:33; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (ii) the variable light chain CDR3 sequence is SEQ ID NO:145; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (iii) the variable light chain CDR3 sequence is SEQ ID NO:146; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (iv) the variable light chain CDR3 sequence is SEQ ID NO:147; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (v) the variable light chain CDR3 sequence is SEQ ID NO:148; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144. (i) the variable light chain CDR3 sequence is SEQ ID NO:33; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (ii) the variable light chain CDR3 sequence is SEQ ID NO:145; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (iii) the variable light chain CDR3 sequence is SEQ ID NO:146; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:31; or (iv) the variable light chain CDR3 sequence is SEQ ID NO:147; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144; or (v) the variable light chain CDR3 sequence is SEQ ID NO:148; the variable light chain CDR2 sequence is SEQ ID NO:32; the variable light chain CDR1 sequence is SEQ ID NO:144.