An apparatus, comprising: a housing; a medicament containment chamber defining an internal volume configured to house a medicament, the medicament containment chamber being disposed within the housing and defining a range of motion of the actuator; a needle; and an actuator including an engagement portion and a plunger portion movably disposed within the internal volume of the medicament containment chamber, the internal volume of the medicament containment chamber, the actuator, and the needle collectively configured such that the plunger portion of the actuator moves within the internal volume of the medicament containment chamber in response to a manually applied force on the engagement portion of the actuator via the housing when a first backpressure is produced on the distal tip of the needle, when the distal tip of the needle is disposed within a first region of target tissue, and movement of the plunger portion of the actuator within the internal volume in response to the force on the actuator is limited when a second backpressure higher than the first backpressure is produced on the distal tip of the needle, when the distal end portion of the needle is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value, characterised in that the apparatus further comprises a hub configured to be coupled to the housing and fluidically coupled to the medicament containment chamber, the hub defining a passageway configured to receive the needle therethrough, the distal end surface of the hub configured to contact a target tissue when a medicament is conveyed through the needle into the target tissue, and wherein the needle is fixedly coupled to the hub. a housing; a medicament containment chamber defining an internal volume configured to house a medicament, the medicament containment chamber being disposed within the housing and defining a range of motion of the actuator; a needle; and an actuator including an engagement portion and a plunger portion movably disposed within the internal volume of the medicament containment chamber, the internal volume of the medicament containment chamber, the actuator, and the needle collectively configured such that the plunger portion of the actuator moves within the internal volume of the medicament containment chamber in response to a manually applied force on the engagement portion of the actuator via the housing when a first backpressure is produced on the distal tip of the needle, when the distal tip of the needle is disposed within a first region of target tissue, and movement of the plunger portion of the actuator within the internal volume in response to the force on the actuator is limited when a second backpressure higher than the first backpressure is produced on the distal tip of the needle, when the distal end portion of the needle is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value, characterised in that the apparatus further comprises a hub configured to be coupled to the housing and fluidically coupled to the medicament containment chamber, the hub defining a passageway configured to receive the needle therethrough, the distal end surface of the hub configured to contact a target tissue when a medicament is conveyed through the needle into the target tissue, and wherein the needle is fixedly coupled to the hub.