mhurhangee/ep-ind-claims huggingface dataset:
A variant of E. coli GTP cyclohydrolase I comprising one or more mutations, wherein, in an E. coli cell comprising a pterin-4a-carbinolamine dehydratase and at least one of a tryptophan hydroxylase, a tyrosine hydroxylase and a phenylalanine hydroxylase (PheH), the variant provides for an increased hydroxylation activity of at least one of the TPH, TH and PheH as compared to native E. coli GCH1, wherein (i) the variant has at least 94% sequence identity to native E. coli GCH1 having the sequence of SEQ ID NO:16 and at least one of the one or more mutations is in an amino acid residue selected from the group consisting of D97, M99, T101, V102, A125, K129, N170, V179, T196, S199, L200, S207, H212, E213, F214, L215 and H221, wherein the mutation in N170 is N170K, N170D or N170L; the mutation in V179 is V179A; the mutation in H212 is H212R or H212K; and the mutation in H221 is H221R or H221K; or (ii) the variant has at least 98% sequence identity to native E. coli GCH1 having the sequence of SEQ ID NO:16 and at least one of the one or more mutations is in the amino acid residue T198, wherein the mutation in T198 is not T198P. in an E. coli cell comprising a pterin-4a-carbinolamine dehydratase and at least one of a tryptophan hydroxylase, a tyrosine hydroxylase and a phenylalanine hydroxylase (PheH), the variant provides for an increased hydroxylation activity of at least one of the TPH, TH and PheH as compared to native E. coli GCH1, wherein (i) the variant has at least 94% sequence identity to native E. coli GCH1 having the sequence of SEQ ID NO:16 and at least one of the one or more mutations is in an amino acid residue selected from the group consisting of D97, M99, T101, V102, A125, K129, N170, V179, T196, S199, L200, S207, H212, E213, F214, L215 and H221, (i) the variant has at least 94% sequence identity to native E. coli GCH1 having the sequence of SEQ ID NO:16 and at least one of the one or more mutations is in an amino acid residue selected from the group consisting of D97, M99, T101, V102, A125, K129, N170, V179, T196, S199, L200, S207, H212, E213, F214, L215 and H221, wherein the mutation in N170 is N170K, N170D or N170L; the mutation in V179 is V179A; the mutation in H212 is H212R or H212K; and the mutation in H221 is H221R or H221K; or (ii) the variant has at least 98% sequence identity to native E. coli GCH1 having the sequence of SEQ ID NO:16 and at least one of the one or more mutations is in the amino acid residue T198, wherein the mutation in T198 is not T198P.
A capsule comprising: - a casing which has an axis of longitudinal extension, the casing comprising a base wall and a lateral wall defining an open cavity, designed to contain an initial product to be added to a fluid to obtain a final product, and a flange edge extending from said lateral wall; - a covering element fixed to the flange edge for closing the cavity, which can be perforated by an extraction device of a dispensing machine in which the capsule can be used; - a closing element fixed to the base wall which can be perforated by a fluid injection device of the dispensing machine comprising piercing blades; wherein - the base wall comprises an edge region, which is annular and extends as far as the lateral wall, a central region, and a groove, which is interposed between the central region and the edge region and is shaped for receiving the piercing blades; and wherein - the closing element has a central portion, configured for being fixed to the central region and an edge portion, configured for being fixed to the edge region; characterized in that - the central region and the edge region extend on respective planes which are offset from each other along the axis and in such a way that an intermediate portion of the closing element, interposed between the central portion and the edge portion for closing the groove, is inclined. - a casing which has an axis of longitudinal extension, the casing comprising a base wall and a lateral wall defining an open cavity, designed to contain an initial product to be added to a fluid to obtain a final product, and a flange edge extending from said lateral wall; - a covering element fixed to the flange edge for closing the cavity, which can be perforated by an extraction device of a dispensing machine in which the capsule can be used; - a closing element fixed to the base wall which can be perforated by a fluid injection device of the dispensing machine comprising piercing blades; wherein - the base wall comprises an edge region, which is annular and extends as far as the lateral wall, a central region, and a groove, which is interposed between the central region and the edge region and is shaped for receiving the piercing blades; and wherein - the closing element has a central portion, configured for being fixed to the central region and an edge portion, configured for being fixed to the edge region; characterized in that - the central region and the edge region extend on respective planes which are offset from each other along the axis and in such a way that an intermediate portion of the closing element, interposed between the central portion and the edge portion for closing the groove, is inclined.
A longitudinal profile which can be used in a roller blind system for the mutual connection of a blind and a roller tube and/or a fastening bar, one and/or the other of the roller tube and/or the fastening bar comprising a longitudinal channel defining a first axis, the profile having an elongated shape to define a second longitudinal axis, the profile comprising: - at least one first longitudinal portion for the mutual connection with one end of the blind; - at least one second longitudinal portion designed to be inserted into the longitudinal channel so that said first and second axis ( X, Y) are mutually parallel or coincident; - a third portion interposed between said first and second portion ( 10, 20) for the mutual connection thereof; characterized in that said at least one third portion is made of a first elastomeric material so as to allow the configuration variation of the profile between a working configuration extended along said axis and a collapsed transportation configuration having longitudinal overall dimensions much smaller than the overall dimensions it has in said working configuration. - at least one first longitudinal portion for the mutual connection with one end of the blind; - at least one second longitudinal portion designed to be inserted into the longitudinal channel so that said first and second axis ( X, Y) are mutually parallel or coincident; - a third portion interposed between said first and second portion ( 10, 20) for the mutual connection thereof;
An extinguishant composition comprising 20 to 50 % by mass of a fuel and 80 to 50 % by mass of a chlorate, and further 6 to 1000 parts by mass of a potassium salt in relation to a total of 100 parts by mass of the fuel and the chlorate, wherein the chlorate is an oxidant compound which burns together with the fuel to generate thermal energy, and the extinguishant composition has a thermal decomposition starting temperature in the range of over 90°C to 260°C, the potassium salt generates potassium radicals by thermal energy, and is at least one of potassium acetate and tripotassium citrate, and the fuel is sodium carboxymethylcellulose.
An attachment of a display for use in a vehicle, comprising: - a rigid bracket having a first end with a connecting flange and a second end with two flat angle brackets, - a display carrier, characterized in that: - the attachment comprises an adapter plate with a plurality of slots (24, 26) and fixation ears, each fixation ear being fixedly mounted into a slot (24, 26), - the adapter plate is mounted on the display carrier, - at least a fixation ear cooperates with a flat angle bracket, and - each fixation ear comprises a base adapted to fit into a slot (24, 26) and a body with a fixing hole. - a rigid bracket having a first end with a connecting flange and a second end with two flat angle brackets, - a display carrier, - the attachment comprises an adapter plate with a plurality of slots (24, 26) and fixation ears, each fixation ear being fixedly mounted into a slot (24, 26), - the adapter plate is mounted on the display carrier, - at least a fixation ear cooperates with a flat angle bracket, and - each fixation ear comprises a base adapted to fit into a slot (24, 26) and a body with a fixing hole.
A composition comprising substantially decellularized epidermis substantially retaining at least one cell adhesion molecule selected from the group consisting of laminin, elastin, fibronectin, and collagen VI.
A medical device comprising: an external electrode assembly comprising a pair of electrodes (108, 50a, 50b, 200) and a camera included with the external electrode assembly, the camera configured to generate image information indicative of a location of at least one of the pair of electrodes relative to the chest of a patient; a processor; at least one output device; and an electronic interface configured to receive the image information from the camera and provide signals representing the image information to the processor, wherein the processor is configured to: receive (222, 250) the signals representing the image information, based on the signals representing the image information, determine (228, 232, 234, 260) electrode positioning feedback for a rescuer, and provide the electrode positioning feedback to the at least one output device, and wherein the at least one output device is configured to provide the electrode positioning feedback as an instruction to move the at least one of the pair of electrodes. an external electrode assembly comprising a pair of electrodes (108, 50a, 50b, 200) and a camera included with the external electrode assembly, the camera configured to generate image information indicative of a location of at least one of the pair of electrodes relative to the chest of a patient; a processor; at least one output device; and an electronic interface configured to receive the image information from the camera and provide signals representing the image information to the processor, wherein the processor is configured to: receive (222, 250) the signals representing the image information, based on the signals representing the image information, determine (228, 232, 234, 260) electrode positioning feedback for a rescuer, and provide the electrode positioning feedback to the at least one output device, and wherein the at least one output device is configured to provide the electrode positioning feedback as an instruction to move the at least one of the pair of electrodes. receive (222, 250) the signals representing the image information, based on the signals representing the image information, determine (228, 232, 234, 260) electrode positioning feedback for a rescuer, and provide the electrode positioning feedback to the at least one output device, and wherein the at least one output device is configured to provide the electrode positioning feedback as an instruction to move the at least one of the pair of electrodes.
A mass spectrometer comprising: a first component comprising an ion block or a first vacuum chamber having a groove; a second component comprising a pumping block, a main housing of said mass spectrometer or a second vacuum chamber; and an annular vacuum chamber seal comprising a main body portion and one or more blade or rib portions which protrude from said main body portion, wherein said main body portion is located in said groove and wherein said one or more blade or rib portions protrude above or beyond a surface of said first component; wherein said annular vacuum chamber seal is substantially arranged in a first plane, and said one or more blade or rib portions protrude from said main body portion in a direction parallel to said first plane; and said second component is arranged to slide, in use, along said surface of said first component thereby deforming said one or more blade or rib portions so that said one or more blade or rib portions form a radial, diametric or piston seal between said first and second components; and said one or more blade or rib portions are arranged and adapted to deform in use and to be compressed towards and against said main body portion as said second component of said mass spectrometer is mounted upon or mated with said first component of said mass spectrometer. a first component comprising an ion block or a first vacuum chamber having a groove; a second component comprising a pumping block, a main housing of said mass spectrometer or a second vacuum chamber; and an annular vacuum chamber seal comprising a main body portion and one or more blade or rib portions which protrude from said main body portion, wherein said main body portion is located in said groove and wherein said one or more blade or rib portions protrude above or beyond a surface of said first component; wherein said annular vacuum chamber seal is substantially arranged in a first plane, and said one or more blade or rib portions protrude from said main body portion in a direction parallel to said first plane; and said second component is arranged to slide, in use, along said surface of said first component thereby deforming said one or more blade or rib portions so that said one or more blade or rib portions form a radial, diametric or piston seal between said first and second components; and said one or more blade or rib portions are arranged and adapted to deform in use and to be compressed towards and against said main body portion as said second component of said mass spectrometer is mounted upon or mated with said first component of said mass spectrometer.
A visual obscurant system for obscuring an object from an observer having a field of view, the system comprising: a sensor for detecting the presence of an external object as well as characteristics that indicate a presence of the object; a light source for emitting light in an electromagnetic spectrum; a source for releasing an obscurant into atmosphere to create a cloud, wherein the obscurant is able to attenuate a portion of the electromagnetic spectrum, and wherein the cloud is able to be positioned within the FOV of the observer so as to obscure the object when the light emitted from the light source is directed towards the cloud; and a controller in communication with the source, the sensor and the light source, the controller being configured to activate the source to release the obscurant into the atmosphere to create the cloud based on the sensor detecting the external object; to modulate the light source at a frequency such that the observer interprets the light as being constant, and to activate the sensor immediately after the light source emits light to view the object. a sensor for detecting the presence of an external object as well as characteristics that indicate a presence of the object; a light source for emitting light in an electromagnetic spectrum; a source for releasing an obscurant into atmosphere to create a cloud, wherein the obscurant is able to attenuate a portion of the electromagnetic spectrum, and wherein the cloud is able to be positioned within the FOV of the observer so as to obscure the object when the light emitted from the light source is directed towards the cloud; and a controller in communication with the source, the sensor and the light source, the controller being configured to activate the source to release the obscurant into the atmosphere to create the cloud based on the sensor detecting the external object; to modulate the light source at a frequency such that the observer interprets the light as being constant, and to activate the sensor immediately after the light source emits light to view the object.
A wind farm (100, 200) capable of quick start up, the wind farm (100, 200) comprising: one or more main wind turbine generators, WTGs,; and an auxiliary wind turbine generator, WTG, having a substantially lower start-up energy requirement than the one or more main WTGs, the auxiliary WTG being local to the wind farm, wherein the auxiliary WTG is arranged to start-up automatically in response to detecting one of a fault and a loss of power on an external electrical grid, and wherein the auxiliary WTG is coupled to supply power to the one or more main WTGs to prepare the one or more main WTGs for start-up. one or more main wind turbine generators, WTGs,; and an auxiliary wind turbine generator, WTG, having a substantially lower start-up energy requirement than the one or more main WTGs, the auxiliary WTG being local to the wind farm, wherein the auxiliary WTG is arranged to start-up automatically in response to detecting one of a fault and a loss of power on an external electrical grid, and wherein the auxiliary WTG is coupled to supply power to the one or more main WTGs to prepare the one or more main WTGs for start-up.
A method of base station, BS, the method comprising: generating control information comprising mode information and frame allocation information; and broadcasting the control information at a first frame of frames allocated to the BS, wherein the mode information indicates either a coexistence mode or a normal mode for the BS, wherein the coexistence mode is a mode where the BS shares a channel on a per frame basis in a superframe with another BS, and wherein the frame allocation information indicates which frames are allocated to the BS. generating control information comprising mode information and frame allocation information; and broadcasting the control information at a first frame of frames allocated to the BS, wherein the mode information indicates either a coexistence mode or a normal mode for the BS, wherein the coexistence mode is a mode where the BS shares a channel on a per frame basis in a superframe with another BS, and wherein the frame allocation information indicates which frames are allocated to the BS.
A method performed by a user equipment for performing cell reselection to a cell providing multimedia broadcast multicast service, MBMS, the method comprising: receiving a system information message comprising: an indication of whether one or more carrier frequencies support MBMS carrier type or further enhanced MBMS, FeMBMS, carrier type; and, for each of the one or more carrier frequencies, an indication of a percentage of available multicast broadcast single frequency network, MBSFN, subframes in each radio frame; selecting, based on a capability of the user equipment and the carrier type and indication of the percentage of available MBSFN subframes of the one or more carrier frequencies, a carrier frequency for cell reselection; and camping on the selected carrier frequency. receiving a system information message comprising: an indication of whether one or more carrier frequencies support MBMS carrier type or further enhanced MBMS, FeMBMS, carrier type; and, for each of the one or more carrier frequencies, an indication of a percentage of available multicast broadcast single frequency network, MBSFN, subframes in each radio frame; selecting, based on a capability of the user equipment and the carrier type and indication of the percentage of available MBSFN subframes of the one or more carrier frequencies, a carrier frequency for cell reselection; and camping on the selected carrier frequency.
A method for determining a characteristic of a patient support surface, the method comprising: pressing a test device into a patient support surface, wherein at least part of the test device has a generally rounded shape having a bottom area (21b, 34) and a side area (21s, 32), the test device comprising a plurality of sensing points extending from the bottom area (21b, 34) upwardly toward the side area (21s, 32); measuring the pressures at the sensing points; transmitting signals representing the pressures from the sensing points to a data device; and storing pressure data representing the pressures in the data device, characterised in that: the pressing operation is carried out at a controlled force by a measuring device; the measuring device comprises a force displacement measuring device; the measuring device presses the test device into the patient support surface at a known force and records displacement data indicating how far the test device has been pressed into the patient support surface; and the method further comprises determining an envelopment parameter of the surface based on a contact area determined from the pressure data and an immersion parameter determined from the displacement data. pressing a test device into a patient support surface, wherein at least part of the test device has a generally rounded shape having a bottom area (21b, 34) and a side area (21s, 32), the test device comprising a plurality of sensing points extending from the bottom area (21b, 34) upwardly toward the side area (21s, 32); measuring the pressures at the sensing points; transmitting signals representing the pressures from the sensing points to a data device; and storing pressure data representing the pressures in the data device, the pressing operation is carried out at a controlled force by a measuring device; the measuring device comprises a force displacement measuring device; the measuring device presses the test device into the patient support surface at a known force and records displacement data indicating how far the test device has been pressed into the patient support surface; and the method further comprises determining an envelopment parameter of the surface based on a contact area determined from the pressure data and an immersion parameter determined from the displacement data.
A display device comprising: a display panel; a vibration generator under the display panel, the vibration generator configured to vibrate responsive to an application of a voltage to the vibration generator; and a vibration transfer layer between the display panel and the vibration generator, the vibration transfer layer comprising a plurality of openings and a vibration transfer part formed into a mesh pattern, and the vibration transfer layer configured to transmit the vibration generated by the vibration generator to the display panel. a display panel; a vibration generator under the display panel, the vibration generator configured to vibrate responsive to an application of a voltage to the vibration generator; and a vibration transfer layer between the display panel and the vibration generator, the vibration transfer layer comprising a plurality of openings and a vibration transfer part formed into a mesh pattern, and the vibration transfer layer configured to transmit the vibration generated by the vibration generator to the display panel.