A compound of Formula: or a tautomer thereof, or a deuterium isotope of each of the above wherein up to 10, preferably up to 6, more preferably up to 3 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned, wherein A is L 1 is selected from the group consisting of: wherein the left side of the moieties are attached to A, L 2 is -SO 2 NR 50 -, wherein the sulfur is attached to L 1; R 50 is hydrogen, a C 1 -C 6 alkyl, a C 2 -C 6 heteroalkyl, a C 2 -C 6 alkenyl, a C 3 -C 6 heteroalkenyl, a C 2 -C 6 alkynyl, a C 3 -C 6 heteroalkynyl, or Z; Z is each R 51 and R 52 independently is hydrogen or a C 1 -C 10 alkyl; X is a hydroxy group, an NH 2 group, or an SH group; L 3 is selected from the group consisting of: wherein the left side of the moieties are attached to L 2 and B is selected from the group consisting of: wherein each R 6 independently is hydrogen, C 1 -C 6 alkoxy, or halo; each R 7 independently is C 1 -C 6 alkyl optionally substituted with 1 to 5 substituents independently selected from halo, hydroxy, C 3 -C 10 cycloalkyl and C 3 -C 10 heterocyclic; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 10 heteroaryl, C 3 -C 10 heterocyclyl, or C 6 -C 10 aryl such as phenyl; or R 6 and R 7 together with the atoms they are attached to form a 5-7 membered ring; or 2 R 6 groups together with the atoms they are attached to form 5-7 membered ring optionally substituted with C 3 -C 8 cycloalkyl. or a tautomer thereof, or a deuterium isotope of each of the above wherein up to 10, preferably up to 6, more preferably up to 3 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned, wherein A is L 1 is selected from the group consisting of: wherein the left side of the moieties are attached to A, L 2 is -SO 2 NR 50 -, wherein the sulfur is attached to L 1; R 50 is hydrogen, a C 1 -C 6 alkyl, a C 2 -C 6 heteroalkyl, a C 2 -C 6 alkenyl, a C 3 -C 6 heteroalkenyl, a C 2 -C 6 alkynyl, a C 3 -C 6 heteroalkynyl, or Z; Z is each R 51 and R 52 independently is hydrogen or a C 1 -C 10 alkyl; X is a hydroxy group, an NH 2 group, or an SH group; L 3 is selected from the group consisting of: wherein the left side of the moieties are attached to L 2 and B is selected from the group consisting of: wherein each R 6 independently is hydrogen, C 1 -C 6 alkoxy, or halo; each R 7 independently is C 1 -C 6 alkyl optionally substituted with 1 to 5 substituents independently selected from halo, hydroxy, C 3 -C 10 cycloalkyl and C 3 -C 10 heterocyclic; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 10 heteroaryl, C 3 -C 10 heterocyclyl, or C 6 -C 10 aryl such as phenyl; or R 6 and R 7 together with the atoms they are attached to form a 5-7 membered ring; or 2 R 6 groups together with the atoms they are attached to form 5-7 membered ring optionally substituted with C 3 -C 8 cycloalkyl. L 1 is selected from the group consisting of: wherein the left side of the moieties are attached to A, L 2 is -SO 2 NR 50 -, wherein the sulfur is attached to L 1; R 50 is hydrogen, a C 1 -C 6 alkyl, a C 2 -C 6 heteroalkyl, a C 2 -C 6 alkenyl, a C 3 -C 6 heteroalkenyl, a C 2 -C 6 alkynyl, a C 3 -C 6 heteroalkynyl, or Z; Z is each R 51 and R 52 independently is hydrogen or a C 1 -C 10 alkyl; X is a hydroxy group, an NH 2 group, or an SH group; L 3 is selected from the group consisting of: wherein the left side of the moieties are attached to L 2 and B is selected from the group consisting of: wherein each R 6 independently is hydrogen, C 1 -C 6 alkoxy, or halo; each R 7 independently is C 1 -C 6 alkyl optionally substituted with 1 to 5 substituents independently selected from halo, hydroxy, C 3 -C 10 cycloalkyl and C 3 -C 10 heterocyclic; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 10 heteroaryl, C 3 -C 10 heterocyclyl, or C 6 -C 10 aryl such as phenyl; or R 6 and R 7 together with the atoms they are attached to form a 5-7 membered ring; or 2 R 6 groups together with the atoms they are attached to form 5-7 membered ring optionally substituted with C 3 -C 8 cycloalkyl. each R 6 independently is hydrogen, C 1 -C 6 alkoxy, or halo; each R 7 independently is C 1 -C 6 alkyl optionally substituted with 1 to 5 substituents independently selected from halo, hydroxy, C 3 -C 10 cycloalkyl and C 3 -C 10 heterocyclic; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 3 -C 10 heteroaryl, C 3 -C 10 heterocyclyl, or C 6 -C 10 aryl such as phenyl; or R 6 and R 7 together with the atoms they are attached to form a 5-7 membered ring; or 2 R 6 groups together with the atoms they are attached to form 5-7 membered ring optionally substituted with C 3 -C 8 cycloalkyl.