An AMPA receptor enhancer compound according to formula A: wherein: W is oxygen X, Y and Z are independently selected from the group consisting of -N, or -CR, wherein: R is H, -Br, -Cl, -F, -CN, -NO 2, -OR 1, -SR 1, -NR 1 2, -C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, wherein: R 1 is H, -C 1 -C 6 branched or un-branched alkyl which, may be un-substituted or substituted, n is 0, 1,2,3,4,5 m is 0, 1,2,3,4,5 pis 1,2,3,4,5 R 2 and R 3 are each independently selected from H, a halogen, -CN, -NO 2, -OR 1, -SR 1, -NR 1 2, CF 3, OH, C=O, a -C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, a -C 2 -C 6 branched or un-branched alkenyl, which may be un-substituted or substituted, a -C 2 -C 6 branched or un-branched alkynyl, which may be un-substituted or substituted, a -C 3 -C 7 cycloalkyl which may be un-substituted or substituted, an aryl which may be un-substituted or substituted, a heterocycle which may be un-substituted or substituted, a carboxyalkyl which may be un-substituted or substituted, a carboxyaryl which may be un-substituted or substituted, a carboxyheteroaryl which may be un-substituted or substituted, a sulfonylalkyl which may be un-substituted or substituted, a sulfonylaryl which may be un-substituted or substituted or a sulfonylheteroaryl which may be un-substituted or substituted, E and F are each independently selected from CH 2 m, CR 2 R 3, A, CH 2 A, CR 2 =CR 3 or are absent, with the proviso that E and F are not both absent; G is CR 2 R 3, A, CH 2 A, CR 2 =CR 3, CH 2 C=O, CH 2 CR 2 R 3, or absent, A is O, S, SO, SO 2, C=O or CR 2 R 3; or a pharmaceutically acceptable salt, solvate, or polymorph thereof. W is oxygen X, Y and Z are independently selected from the group consisting of -N, or -CR, R is H, -Br, -Cl, -F, -CN, -NO 2, -OR 1, -SR 1, -NR 1 2, -C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, R 1 is H, -C 1 -C 6 branched or un-branched alkyl which, may be un-substituted or substituted, n is 0, 1,2,3,4,5 m is 0, 1,2,3,4,5 pis 1,2,3,4,5 R 2 and R 3 are each independently selected from H, a halogen, -CN, -NO 2, -OR 1, -SR 1, -NR 1 2, CF 3, OH, C=O, a -C 1 -C 6 branched or un-branched alkyl, which may be un-substituted or substituted, a -C 2 -C 6 branched or un-branched alkenyl, which may be un-substituted or substituted, a -C 2 -C 6 branched or un-branched alkynyl, which may be un-substituted or substituted, a -C 3 -C 7 cycloalkyl which may be un-substituted or substituted, an aryl which may be un-substituted or substituted, a heterocycle which may be un-substituted or substituted, a carboxyalkyl which may be un-substituted or substituted, a carboxyaryl which may be un-substituted or substituted, a carboxyheteroaryl which may be un-substituted or substituted, a sulfonylalkyl which may be un-substituted or substituted, a sulfonylaryl which may be un-substituted or substituted or a sulfonylheteroaryl which may be un-substituted or substituted, E and F are each independently selected from CH 2 m, CR 2 R 3, A, CH 2 A, CR 2 =CR 3 or are absent, with the proviso that E and F are not both absent; G is CR 2 R 3, A, CH 2 A, CR 2 =CR 3, CH 2 C=O, CH 2 CR 2 R 3, or absent, A is O, S, SO, SO 2, C=O or CR 2 R 3; or a pharmaceutically acceptable salt, solvate, or polymorph thereof.