A method of electrochemically measuring an analyte in a fluid sample, the method comprising the steps of: applying an electrical test sequence to an electrochemical biosensor (20, 420), the biosensor (20, 420) comprising: an electrode system, a reagent in electrical communication with the electrode system, and a receptacle configured to contact the fluid sample provided to the biosensor (20, 420), with the fluid sample in fluidic contact with the reagent, wherein the test sequence comprises at least one DC block, the at least one DC block includes at least one excitation potential pulse and at least one recovery potential pulse, each potential configured to produce response information to the test sequence, and wherein a closed circuit condition of the electrode system is maintained during the at least one DC block; measuring the response information from the test sequence; and building across- and within-pulse descriptors encoding magnitude and shape characteristics of the response to the test sequence; and determining an analyte concentration of the fluid sample based upon the descriptors, wherein the across- and within-pulse descriptors encode transformed slope information and transformed intercept information of the excitation current response information and the transformed recovery current response information. applying an electrical test sequence to an electrochemical biosensor (20, 420), the biosensor (20, 420) comprising: an electrode system, a reagent in electrical communication with the electrode system, and a receptacle configured to contact the fluid sample provided to the biosensor (20, 420), with the fluid sample in fluidic contact with the reagent, wherein the test sequence comprises at least one DC block, the at least one DC block includes at least one excitation potential pulse and at least one recovery potential pulse, each potential configured to produce response information to the test sequence, and wherein a closed circuit condition of the electrode system is maintained during the at least one DC block; measuring the response information from the test sequence; and building across- and within-pulse descriptors encoding magnitude and shape characteristics of the response to the test sequence; and determining an analyte concentration of the fluid sample based upon the descriptors, wherein the across- and within-pulse descriptors encode transformed slope information and transformed intercept information of the excitation current response information and the transformed recovery current response information. an electrode system, a reagent in electrical communication with the electrode system, and a receptacle configured to contact the fluid sample provided to the biosensor (20, 420), measuring the response information from the test sequence; and building across- and within-pulse descriptors encoding magnitude and shape characteristics of the response to the test sequence; and determining an analyte concentration of the fluid sample based upon the descriptors, wherein the across- and within-pulse descriptors encode transformed slope information and transformed intercept information of the excitation current response information and the transformed recovery current response information.