A drug delivery connector system comprising: an actuator and a drug delivery connector, wherein the drug delivery connector comprises: a housing including an open distal end and an open proximal end; a distal connection portion extending from the housing to the open distal end; a proximal connection portion extending from the housing to the open proximal end; and wherein the housing comprises a chamber including a distal wall disposed between the chamber and the distal connection portion, wherein the chamber is in fluid communication with the open distal end and the open proximal end; wherein the drug delivery connector further comprises a ball valve disposed within the chamber wherein the distal wall includes a bore having a perimeter configured to contact the ball valve, wherein the ball valve is moveable in a distal direction to form a releasable seal with the perimeter of the bore to prevent fluid flow from the open proximal end to the open distal end upon application of force in a distal direction on the ball valve applied by fluid upon attachment of a container containing the fluid to the proximal connection portion, and the ball valve is movable in a proximal direction to release the releasable seal to permit fluid flow from the open proximal end to the open distal end; wherein the actuator is configured for attachment to the open distal end of the housing, the actuator comprising a projection extending in the proximal direction and including at least one aperture in fluid communication with an open distal end of the actuator, such that upon attachment of the actuator to the open distal end of the housing, the projection applies a force on the ball valve in the proximal direction to move the ball valve in the proximal direction, characterised in that the ball valve is not springloaded. a housing including an open distal end and an open proximal end; a distal connection portion extending from the housing to the open distal end; a proximal connection portion extending from the housing to the open proximal end; and wherein the housing comprises a chamber including a distal wall disposed between the chamber and the distal connection portion, wherein the chamber is in fluid communication with the open distal end and the open proximal end; wherein the drug delivery connector further comprises a ball valve disposed within the chamber wherein the distal wall includes a bore having a perimeter configured to contact the ball valve, wherein the ball valve is moveable in a distal direction to form a releasable seal with the perimeter of the bore to prevent fluid flow from the open proximal end to the open distal end upon application of force in a distal direction on the ball valve applied by fluid upon attachment of a container containing the fluid to the proximal connection portion, and the ball valve is movable in a proximal direction to release the releasable seal to permit fluid flow from the open proximal end to the open distal end; wherein the actuator is configured for attachment to the open distal end of the housing, the actuator comprising a projection extending in the proximal direction and including at least one aperture in fluid communication with an open distal end of the actuator, such that upon attachment of the actuator to the open distal end of the housing, the projection applies a force on the ball valve in the proximal direction to move the ball valve in the proximal direction, characterised in that the ball valve is not springloaded.