A medical connector system comprising: a first connector having a proximal end and a distal end, the first connector comprising a housing defining a central opening that receives a carrier member, a biasing member, a needle cannula, the biasing member engaging and biasing the carrier member towards the distal end of the first connector, the carrier member having at least one sealing member; and a second connector having an outer surface, a proximal end, and a distal end, the proximal end of the second connector is configured to be at least partially disposed within a distal end of the housing of the first connector, characterized in that the first connector comprises a cam member and the cam member has at least one projection extending into the central opening of the housing of the first connector with the cam member being rotatable relative to the housing of the first connector, and in that the outer surface of the second connector comprises at least one groove for receiving the at least one projection, wherein upon application and release of a first set of opposing axial forces applied to the proximal end of the first connector and the distal end of the second connector, the first connector is adapted to be locked to the second connector with the at least one projection engaged with the at least one groove and the needle cannula extending through the at least one sealing member and, upon application and release of a second set of opposing axial forces to the proximal end of the first connector and the distal end of the second connector, the first connector is adapted to be released from the second connector with the at least one projection released from engagement with the at least one groove. a first connector having a proximal end and a distal end, the first connector comprising a housing defining a central opening that receives a carrier member, a biasing member, a needle cannula, the biasing member engaging and biasing the carrier member towards the distal end of the first connector, the carrier member having at least one sealing member; and a second connector having an outer surface, a proximal end, and a distal end, the proximal end of the second connector is configured to be at least partially disposed within a distal end of the housing of the first connector, characterized in that the first connector comprises a cam member and the cam member has at least one projection extending into the central opening of the housing of the first connector with the cam member being rotatable relative to the housing of the first connector, and in that the outer surface of the second connector comprises at least one groove for receiving the at least one projection, wherein upon application and release of a first set of opposing axial forces applied to the proximal end of the first connector and the distal end of the second connector, the first connector is adapted to be locked to the second connector with the at least one projection engaged with the at least one groove and the needle cannula extending through the at least one sealing member and, upon application and release of a second set of opposing axial forces to the proximal end of the first connector and the distal end of the second connector, the first connector is adapted to be released from the second connector with the at least one projection released from engagement with the at least one groove.