A sample processing device with a valving structure, an input chamber (115, 215) and a process chamber (150, 250), the sample processing device configured to rotate about an axis of rotation (A-A, B-B) and the valving structure comprising: a fluid pathway (128, 228, 278) that forms a capillary valve (130, 230); a septum valve (132, 232) comprising a valve chamber (134, 234) and a valve septum (136, 236), wherein the capillary valve is in series with the septum valve, and the capillary valve is upstream of and in fluid communication with an inlet or upstream end of the valve septum, and the capillary valve is positioned radially inwardly of the septum valve, relative to the axis of rotation; wherein the input chamber (115, 215) is in fluid communication with an inlet of the fluid pathway; the process chamber (150, 250) being positioned to be in fluid communication with an outlet of the valve chamber (134, 234); the valve septum (136, 236) being located between the valve chamber and the process chamber, the valve septum having: a first side, a second side opposite the first side, a closed configuration wherein the valve chamber (134, 234) and the process chamber (150, 250) are not in fluid communication, and an open configuration in which an opening or void is formed in the valve septum (136, 236) and the valve chamber (134, 234) and the process chamber (150, 250) are in fluid communication, wherein the valve septum (136, 236) is configured to be changed from the closed configuration to the open configuration by directing electromagnetic energy at the first side of the valve septum; and the fluid pathway is (128, 228, 278) in fluid communication with an inlet of the valve chamber (134, 234), wherein the fluid pathway is configured to inhibit a liquid from entering the valve chamber and collecting adjacent the second side of the valve septum when the valve septum is in the closed configuration. a fluid pathway (128, 228, 278) that forms a capillary valve (130, 230); a septum valve (132, 232) comprising a valve chamber (134, 234) and a valve septum (136, 236), wherein the capillary valve is in series with the septum valve, and the capillary valve is upstream of and in fluid communication with an inlet or upstream end of the valve septum, and the capillary valve is positioned radially inwardly of the septum valve, relative to the axis of rotation; wherein the input chamber (115, 215) is in fluid communication with an inlet of the fluid pathway; the process chamber (150, 250) being positioned to be in fluid communication with an outlet of the valve chamber (134, 234); the valve septum (136, 236) being located between the valve chamber and the process chamber, the valve septum having: a first side, a second side opposite the first side, a closed configuration wherein the valve chamber (134, 234) and the process chamber (150, 250) are not in fluid communication, and an open configuration in which an opening or void is formed in the valve septum (136, 236) and the valve chamber (134, 234) and the process chamber (150, 250) are in fluid communication, wherein the valve septum (136, 236) is configured to be changed from the closed configuration to the open configuration by directing electromagnetic energy at the first side of the valve septum; and a first side, a second side opposite the first side, a closed configuration wherein the valve chamber (134, 234) and the process chamber (150, 250) are not in fluid communication, and an open configuration in which an opening or void is formed in the valve septum (136, 236) and the valve chamber (134, 234) and the process chamber (150, 250) are in fluid communication, wherein the valve septum (136, 236) is configured to be changed from the closed configuration to the open configuration by directing electromagnetic energy at the first side of the valve septum; and the fluid pathway is (128, 228, 278) in fluid communication with an inlet of the valve chamber (134, 234), wherein the fluid pathway is configured to inhibit a liquid from entering the valve chamber and collecting adjacent the second side of the valve septum when the valve septum is in the closed configuration.