A compound of Formula I, wherein A and B form, together with the atoms to which they are attached, wherein the atoms marked with * and *' are bonded to the parent molecular moiety; X is CR 5 or N; Y is CR 6 or N; Z is CR 4 or N, provided that when Y or X is N, then Z is not N; R 1 is (C 1 -C 6)alkyl, cyclo(C 3 -C 6)alkyl, halo(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy(C 1 -C 6)alkyl, (C 1 -C 6)alkyl-S-(C 1 -C 6)alkyl, heterocyclyl, heterocyclyl(C 1 -C 3)alkyl, phenyl, phenyl(C 1 -C 3)alkyl, or phenoxy(C 1 -C 6)alkyl, wherein said cyclo(C 3 -C 6)alkyl, heterocyclyl, or phenyl is unsubstituted or substituted with 1 or 2 substituent(s) each independently being halogen, (C 1 -C 5)alkyl, halo(C 1 -C 5)alkyl, (C 1 -C 5)alkoxy, cyclo(C 3 -C 6)alkyl, CN, halo(C 1 -C 5)alkoxy, (C 1 -C 5)alkyl-S-, (C 1 -C 5)alkyl-(S=O)-, (C 1 -C 5)alkyl-(O=S=O)-, (C 1 -C 3)alkylamino or di(C 1 -C 3)alkylamino; R 2 is (C 1 -C 6)alkyl; R 3 is (C 1 -C 6)alkyl; R 4 is H, halogen, (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, halo(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy, (C 1 -C 6)alkoxy(C 1 -C 6)alkoxy, (C 1 -C 6)alkyl-S-, (C 1 -C 6)alkylamino, halo(C 1 -C 6)alkylamino, (C 1 -C 6)alkyl(C=O), CN, or heterocyclyl; R 5 is H, halogen, (C 1 -C 6)alkyl, cyclo(C 3 -C 6)alkyl, (C 1 -C 6)alkoxy, halo(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy, (C 1 -C 6)alkoxy(C 1 -C 6)alkoxy, (C 1 -C 6)alkyl-S-, (C 1 -C 6)alkyl-(S=O)-, (C 1 -C 6)alkyl-(O=S=O)-, halo(C 1 -C 6)alkyl-S-, halo(C 1 -C 6)alkylamino, (C 1 -C 6)alkyl(C=O), or CN; and R 6 is H, halogen, (C 1 -C 6)alkyl, or halo(C 1 -C 6)alkyl; or R 1 and R 6 form, together with the atoms to which they are attached, a condensed 5 or 6 membered saturated or unsaturated heterocyclic ring containing, in addition to the nitrogen atom to which R 1 is attached, 0 or 1 further heteroatom selected from N, O, and S, wherein said heterocyclic ring is unsubstituted or substituted with 1 or 2 substituent(s) each independently being (C 1 -C 2)alkyl or halogen; or R 4 and R 5 form, together with the carbon ring atoms to which they are attached, a condensed 5, 6 or 7 membered saturated or unsaturated carbocyclic ring or a condensed 5, 6, or 7 membered saturated or unsaturated heterocyclic ring containing 1 or 2 heteroatom(s) selected from N, O, and S, wherein said carbocyclic or heterocyclic ring is unsubstituted or substituted with 1 or 2 substituent(s) each independently being (C 1 -C 2)alkyl or halogen; or a pharmaceutically acceptable salt or ester thereof; with the proviso that the compound is not 2-(methylamino)- N- (2-methylbut-3-yn-2-yl)benzamide or N -(2-methylbut-3-yn-2-yl)-2-(propylamino)benzamide. X is CR 5 or N; Y is CR 6 or N; Z is CR 4 or N, provided that when Y or X is N, then Z is not N; R 1 is (C 1 -C 6)alkyl, cyclo(C 3 -C 6)alkyl, halo(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy(C 1 -C 6)alkyl, (C 1 -C 6)alkyl-S-(C 1 -C 6)alkyl, heterocyclyl, heterocyclyl(C 1 -C 3)alkyl, phenyl, phenyl(C 1 -C 3)alkyl, or phenoxy(C 1 -C 6)alkyl, wherein said cyclo(C 3 -C 6)alkyl, heterocyclyl, or phenyl is unsubstituted or substituted with 1 or 2 substituent(s) each independently being halogen, (C 1 -C 5)alkyl, halo(C 1 -C 5)alkyl, (C 1 -C 5)alkoxy, cyclo(C 3 -C 6)alkyl, CN, halo(C 1 -C 5)alkoxy, (C 1 -C 5)alkyl-S-, (C 1 -C 5)alkyl-(S=O)-, (C 1 -C 5)alkyl-(O=S=O)-, (C 1 -C 3)alkylamino or di(C 1 -C 3)alkylamino; R 2 is (C 1 -C 6)alkyl; R 3 is (C 1 -C 6)alkyl; R 4 is H, halogen, (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, halo(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy, (C 1 -C 6)alkoxy(C 1 -C 6)alkoxy, (C 1 -C 6)alkyl-S-, (C 1 -C 6)alkylamino, halo(C 1 -C 6)alkylamino, (C 1 -C 6)alkyl(C=O), CN, or heterocyclyl; R 5 is H, halogen, (C 1 -C 6)alkyl, cyclo(C 3 -C 6)alkyl, (C 1 -C 6)alkoxy, halo(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy(C 1 -C 6)alkyl, halo(C 1 -C 6)alkoxy, (C 1 -C 6)alkoxy(C 1 -C 6)alkoxy, (C 1 -C 6)alkyl-S-, (C 1 -C 6)alkyl-(S=O)-, (C 1 -C 6)alkyl-(O=S=O)-, halo(C 1 -C 6)alkyl-S-, halo(C 1 -C 6)alkylamino, (C 1 -C 6)alkyl(C=O), or CN; and R 6 is H, halogen, (C 1 -C 6)alkyl, or halo(C 1 -C 6)alkyl;