A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is H, -CN, halogen, C 1 -C 4 straight or branched alkyl, -O-(C 3 -C 5 cycloalkyl), or -O-(C 1 -C 4 straight or branched alkyl) wherein: the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; and when R 1 is not H, -CN or halogen, it is optionally substituted with one or more halogens; each R 2 is independently hydrogen, halogen or C 1 -C 4 straight or branched alkyl; R 3 is H, -OH or halogen; L 3 is C(R 60) 2, O or NR 50; each R 60 is independently H, -OH, -CN, -O t -(C 3 -C 5 cycloalkyl), -O-(C 1 -C 4 straight or branched alkyl), or -C -N(R 601) 2 wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; each R 50 is independently H, -C -O t -(C 1 -C 4 straight or branched alkyl), -C -O t -(C 3 -C 5 cyclic alkyl), -C 3 -C 5 cyclic alkyl optionally containing an oxygen or nitrogen heteroatom, -C -N(R 501) 2, or C 1 -C 4 straight or branched alkyl wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; n is 1, 2 or 3; m is 1 or 2; R 21 is H, halogen, C 1 -C 4 straight or branched alkyl, C 3 -C 5 cycloalkyl wherein the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom R 22 is H, halogen, C 1 -C 2 alkyl; each R 26 is independently -OH, -CN, halogen, C 1 -C 4 straight or branched alkyl, -(C 1 -C 4 alkyl) t -O t -(C 3 -C 5 cycloalkyl), -(C 1 -C 4 alkyl) t -O-(C 1 -C 4 straight or branched alkyl), -C -O t -(C 1 -C 4 alkyl), or -C -N(R 501) 2 wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; s is 0, 1 or 2; each R 601 and R 501 is independently H or C 1 -C 4 straight or branched alkyl; and wherein two of R 26, R 60, R 50, R 501 and R 601 optionally join to form a ring wherein the two of R 26, R 60, R 50, R 501 and R 601 may be two R 26, two R 60, two R 50, two R 501 or two R 601. R 1 is H, -CN, halogen, C 1 -C 4 straight or branched alkyl, -O-(C 3 -C 5 cycloalkyl), or -O-(C 1 -C 4 straight or branched alkyl) wherein: the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; and when R 1 is not H, -CN or halogen, it is optionally substituted with one or more halogens; the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; and when R 1 is not H, -CN or halogen, it is optionally substituted with one or more halogens; each R 2 is independently hydrogen, halogen or C 1 -C 4 straight or branched alkyl; R 3 is H, -OH or halogen; L 3 is C(R 60) 2, O or NR 50; each R 60 is independently H, -OH, -CN, -O t -(C 3 -C 5 cycloalkyl), -O-(C 1 -C 4 straight or branched alkyl), or -C -N(R 601) 2 wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; each R 50 is independently H, -C -O t -(C 1 -C 4 straight or branched alkyl), -C -O t -(C 3 -C 5 cyclic alkyl), -C 3 -C 5 cyclic alkyl optionally containing an oxygen or nitrogen heteroatom, -C -N(R 501) 2, or C 1 -C 4 straight or branched alkyl wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; n is 1, 2 or 3; m is 1 or 2; R 21 is H, halogen, C 1 -C 4 straight or branched alkyl, C 3 -C 5 cycloalkyl wherein the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom R 22 is H, halogen, C 1 -C 2 alkyl; each R 26 is independently -OH, -CN, halogen, C 1 -C 4 straight or branched alkyl, -(C 1 -C 4 alkyl) t -O t -(C 3 -C 5 cycloalkyl), -(C 1 -C 4 alkyl) t -O-(C 1 -C 4 straight or branched alkyl), -C -O t -(C 1 -C 4 alkyl), or -C -N(R 501) 2 wherein: t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; t is 0 or 1, and the C 3 -C 5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; s is 0, 1 or 2; each R 601 and R 501 is independently H or C 1 -C 4 straight or branched alkyl; and wherein two of R 26, R 60, R 50, R 501 and R 601 optionally join to form a ring wherein the two of R 26, R 60, R 50, R 501 and R 601 may be two R 26, two R 60, two R 50, two R 501 or two R 601.