A method for producing an optically-active amine compound by using the following enzymes to, or more preferably the following enzymes (A') to (C'), in an identical reaction system to convert a ketone compound into a corresponding optically-active amine compound in which a carbon atom with an amino group bonded thereto serves as an asymmetric point: a transaminase, using an α-amino acid as an amino-group donor, which has an ability to act on the ketone compound to convert the ketone compound into the optically-active amine compound; an α-keto acid reductase, using a reduced β-nicotinamide adenine dinucleotide (NADH) or a reduced β-nicotinamide adenine dinucleotide phosphate (NADPH) as a coenzyme, which has an ability to reduce, to an α-hydroxy acid, an α-keto acid produced from the α-amino acid through action of the transaminase and which does not act on the ketone compound; an enzyme that has an ability to convert, into NADH, an oxidized β-nicotinamide adenine dinucleotide (NAD +) produced from the NADH through action of the α-keto acid reductase or that has an ability to convert, into NADPH, an oxidized β-nicotinamide adenine dinucleotide phosphate (NADP +) produced from the NADPH through action of the α-keto acid reductase; (A') a transaminase, using α-alanine as an amino-group donor, which has an ability to act on a ketone compound to convert the ketone compound into a corresponding optically-active amine compound in which a carbon atom with an amino group bonded thereto serves as an asymmetric point; (B') an α-keto acid reductase, using a reduced β-nicotinamide adenine dinucleotide (NADH) as a coenzyme, which has an ability to reduce, to a lactic acid, a pyruvic acid produced from the α-alanine through action of the transaminase (A') and which does not act on the ketone compound; and (C') an enzyme that has an ability to convert, into NADH, an oxidized β-nicotinamide adenine dinucleotide (NAD +) produced from the NADH through action of the α-keto acid reductase (B'). a transaminase, using an α-amino acid as an amino-group donor, which has an ability to act on the ketone compound to convert the ketone compound into the optically-active amine compound; an α-keto acid reductase, using a reduced β-nicotinamide adenine dinucleotide (NADH) or a reduced β-nicotinamide adenine dinucleotide phosphate (NADPH) as a coenzyme, which has an ability to reduce, to an α-hydroxy acid, an α-keto acid produced from the α-amino acid through action of the transaminase and which does not act on the ketone compound; an enzyme that has an ability to convert, into NADH, an oxidized β-nicotinamide adenine dinucleotide (NAD +) produced from the NADH through action of the α-keto acid reductase or that has an ability to convert, into NADPH, an oxidized β-nicotinamide adenine dinucleotide phosphate (NADP +) produced from the NADPH through action of the α-keto acid reductase; (A') a transaminase, using α-alanine as an amino-group donor, which has an ability to act on a ketone compound to convert the ketone compound into a corresponding optically-active amine compound in which a carbon atom with an amino group bonded thereto serves as an asymmetric point; (B') an α-keto acid reductase, using a reduced β-nicotinamide adenine dinucleotide (NADH) as a coenzyme, which has an ability to reduce, to a lactic acid, a pyruvic acid produced from the α-alanine through action of the transaminase (A') and which does not act on the ketone compound; and (C') an enzyme that has an ability to convert, into NADH, an oxidized β-nicotinamide adenine dinucleotide (NAD +) produced from the NADH through action of the α-keto acid reductase (B').