Method for the synthesis by micellar catalysis of a chimeric conjugate molecule comprising a small organic candidate compound covalently conjugated to a first DNA identifier tag, wherein said method comprises (a) combining in an aqueous solvent a conjugate starting molecule comprising a first small organic molecule covalently conjugated to the first DNA identifier tag; a second small organic molecule that is to be reacted with the first small organic molecule covalently linked to the first DNA identifier tag to yield the chimeric conjugate molecule; and an amphiphilic block copolymer comprising a hydrophilic block and a hydrophobic block, wherein the hydrophobic block is functionalized with a catalyst that catalyzes the reaction between the first and second small organic molecule, to yield a reaction mixture with the aqueous solvent as the continuous phase, wherein the amphiphilic block copolymer is added in an amount such that the final concentration of the amphiphilic block copolymer in the reaction mixture is above the critical micelle concentration of said amphiphilic block copolymer; (b) subjecting the reaction mixture obtained in step (a) to conditions that allow micelle formation of the amphiphilic block copolymer and the reaction between the first and second small organic molecule in the interior of the micelle; and (c) purifying the chimeric conjugate molecule from the reaction mixture. a small organic candidate compound covalently conjugated to a first DNA identifier tag, wherein said method comprises (a) combining in an aqueous solvent a conjugate starting molecule comprising a first small organic molecule covalently conjugated to the first DNA identifier tag; a second small organic molecule that is to be reacted with the first small organic molecule covalently linked to the first DNA identifier tag to yield the chimeric conjugate molecule; and an amphiphilic block copolymer comprising a hydrophilic block and a hydrophobic block, wherein the hydrophobic block is functionalized with a catalyst that catalyzes the reaction between the first and second small organic molecule, to yield a reaction mixture with the aqueous solvent as the continuous phase, wherein the amphiphilic block copolymer is added in an amount such that the final concentration of the amphiphilic block copolymer in the reaction mixture is above the critical micelle concentration of said amphiphilic block copolymer; (b) subjecting the reaction mixture obtained in step (a) to conditions that allow micelle formation of the amphiphilic block copolymer and the reaction between the first and second small organic molecule in the interior of the micelle; and (c) purifying the chimeric conjugate molecule from the reaction mixture. (a) combining in an aqueous solvent a conjugate starting molecule comprising a first small organic molecule covalently conjugated to the first DNA identifier tag; a second small organic molecule that is to be reacted with the first small organic molecule covalently linked to the first DNA identifier tag to yield the chimeric conjugate molecule; and an amphiphilic block copolymer comprising a hydrophilic block and a hydrophobic block, wherein the hydrophobic block is functionalized with a catalyst that catalyzes the reaction between the first and second small organic molecule, to yield a reaction mixture with the aqueous solvent as the continuous phase, wherein the amphiphilic block copolymer is added in an amount such that the final concentration of the amphiphilic block copolymer in the reaction mixture is above the critical micelle concentration of said amphiphilic block copolymer; a conjugate starting molecule comprising a first small organic molecule covalently conjugated to the first DNA identifier tag; a second small organic molecule that is to be reacted with the first small organic molecule covalently linked to the first DNA identifier tag to yield the chimeric conjugate molecule; and an amphiphilic block copolymer comprising a hydrophilic block and a hydrophobic block, wherein the hydrophobic block is functionalized with a catalyst that catalyzes the reaction between the first and second small organic molecule, to yield a reaction mixture with the aqueous solvent as the continuous phase, wherein the amphiphilic block copolymer is added in an amount such that the final concentration of the amphiphilic block copolymer in the reaction mixture is above the critical micelle concentration of said amphiphilic block copolymer; to yield a reaction mixture with the aqueous solvent as the continuous phase, wherein the amphiphilic block copolymer is added in an amount such that the final concentration of the amphiphilic block copolymer in the reaction mixture is above the critical micelle concentration of said amphiphilic block copolymer; (b) subjecting the reaction mixture obtained in step (a) to conditions that allow micelle formation of the amphiphilic block copolymer and the reaction between the first and second small organic molecule in the interior of the micelle; and (c) purifying the chimeric conjugate molecule from the reaction mixture.