mhurhangee/ep-ind-claims huggingface dataset:
A lyophilized formulation prepared by lyophilizing an aqueous formulation having a pH of 6.5 and comprising (i) a hypofucosylated or non-fucosylated anti-BAFFR antibody wherein the antibody has a concentration of 50 mg/ml, and wherein said anti-BAFFR antibody includes heavy chain CDR1, CDR2 and CDR3 of SEQ ID NOs 3, 4 and 5 respectively, and light chain CDR1, CDR2 and CDR3 of SEQ ID NOs: 6, 7 and 8, (ii) 90 mM sucrose as a stabilizer, (iii) 7 mM histidine as a buffering agent, (iv) 0.02% polysorbate 80 as a surfactant, and (v) 17 mM arginine-HCL. (i) a hypofucosylated or non-fucosylated anti-BAFFR antibody wherein the antibody has a concentration of 50 mg/ml, and wherein said anti-BAFFR antibody includes heavy chain CDR1, CDR2 and CDR3 of SEQ ID NOs 3, 4 and 5 respectively, and light chain CDR1, CDR2 and CDR3 of SEQ ID NOs: 6, 7 and 8, (ii) 90 mM sucrose as a stabilizer, (iii) 7 mM histidine as a buffering agent, (iv) 0.02% polysorbate 80 as a surfactant, and (v) 17 mM arginine-HCL.
An aerial lift including: - a lower part (3, 5) equipped with members for connecting to the ground; - a platform comprising a floor partially surrounded by a guardrail in which an access zone is arranged; - a lift structure supporting the platform; characterized in that the platform is equipped with a lighting system (100, 101, 103, 104, 105), other than headlights, suitable for illuminating at least part of a space inside the platform, including at least the access zone. - a lower part (3, 5) equipped with members for connecting to the ground; - a platform comprising a floor partially surrounded by a guardrail in which an access zone is arranged; - a lift structure supporting the platform;
Rotor comprising at least one air-conducting device for turbomachinery, comprising a plurality of air-conducting conduits for guiding air out of an outer annular space radially in the direction of a rotor shaft and comprising a bearing ring for arranging the air-conducting conduits in a radially closed intermediate space between two adjacent rotor disks (3, 4), the bearing ring forming a radially internal boundary of the intermediate space when the air-conducting device is mounted and the air-conducting conduits each having an inflow region (38, 40) oriented in the direction of rotation, characterized in that the air-conducting device is manufactured as a single piece such that the air-conducting conduits are generatively formed together with the bearing ring.
A mechanical seal device for sealing a fluid inside of machine at a space formed between a stuffing box and a rotary shaft, comprising: a seal cover attached to the stuffing box, a stationary seal ring attached to the seal cover and provided with a first seal surface, a rotary seal ring attached to the rotary shaft and provided with a second seal surface capable of sliding on the first seal surface, and a collar rotating together with the rotary shaft, wherein a clearance (b) is formed between a back surface opposing to the second seal surface of the rotary seal ring and the collar, and the rotary seal ring is elastically held in an axial direction of the rotary shaft to rotate together with the collar, characterized in that the stationary seal ring and the rotary seal ring are composed of SiC, the seal surface of either one of the stationary seal ring and the rotary seal ring is formed on a nose portion having a rectangular cross-section, and a face width (a) of the seal surface formed on the nose portion is formed so as to be narrower than the other seal surface and is 1.4 to 1.8 mm, and the length of the nose portion in the axial direction is 1.0 to 2.0 mm, the clearance (b) formed between the back surface opposing to the second seal surface of the rotary seal ring and the collar is 0.4 to 3.0 mm, a balance ratio of the stationary seal ring is set to be 0.8 to 1.20, an innermost diameter ratio of the stationary seal ring is set to be 1.09 to 1.30, and a ratio (a/b) of the width (a) of the first seal surface of the stationary seal ring and the clearance (b) is 0.35 to 5. a seal cover attached to the stuffing box, a stationary seal ring attached to the seal cover and provided with a first seal surface, a rotary seal ring attached to the rotary shaft and provided with a second seal surface capable of sliding on the first seal surface, and a collar rotating together with the rotary shaft, the stationary seal ring and the rotary seal ring are composed of SiC, the seal surface of either one of the stationary seal ring and the rotary seal ring is formed on a nose portion having a rectangular cross-section, and a face width (a) of the seal surface formed on the nose portion is formed so as to be narrower than the other seal surface and is 1.4 to 1.8 mm, and the length of the nose portion in the axial direction is 1.0 to 2.0 mm, the clearance (b) formed between the back surface opposing to the second seal surface of the rotary seal ring and the collar is 0.4 to 3.0 mm, a balance ratio of the stationary seal ring is set to be 0.8 to 1.20, an innermost diameter ratio of the stationary seal ring is set to be 1.09 to 1.30, and a ratio (a/b) of the width (a) of the first seal surface of the stationary seal ring and the clearance (b) is 0.35 to 5.
A low-temperature storage device for storing a plurality of objects, said device comprising, a storage chamber having a bottom section and a top section, a refrigerator device adapted and structured to cool said storage chamber to a storage temperature below 0°C, in particular below -20°C, vertical, insulating walls enclosing said storage chamber, a transfer location arranged outside said storage chamber, an access opening arranged in at least one said insulating walls between said storage chamber and said transfer location, a cassette store arranged in said bottom section of said storage chamber and forming a plurality of cassette locations, a plurality of storage cassettes arranged beside each other in said cassette locations, wherein each storage cassette comprises a plurality of storage locations arranged vertically above each other, wherein each storage location is structured and adapted to receive at least one of said objects, a cassette handler located in said storage chamber comprising a) a cassette lift adapted and structured to move an individual storage cassette between its cassette location and said top section and b) a cassette holder adapted and structured to hold a storage cassette raised by the cassette lift in a raised position in said top section, c) a transport mechanism (27a, 27b) structured and adapted to horizontally displace said cassette holder, with a raised storage cassette, characterized in that said transport mechanism (27a, 27b) is structured and adapted to horizontally displace said cassette holder, with the raised storage cassette, between a position where said raised storage cassette is vertically above its cassette location to an access position where said raised storage cassette is adjacent to said access opening and is accessible through it. a) a cassette lift adapted and structured to move an individual storage cassette between its cassette location and said top section and b) a cassette holder adapted and structured to hold a storage cassette raised by the cassette lift in a raised position in said top section, c) a transport mechanism (27a, 27b) structured and adapted to horizontally displace said cassette holder, with a raised storage cassette,
An adapter (100, 100') for charging and/or recharging a battery powered device (10, 10') battery of a first type utilizing a charging device for a battery of a second battery type, wherein the first and second battery types are different, said adapter comprising: a first pair of terminals (122, 124) in a configuration for electrically connecting to charging terminals of a charging device for a battery of the second battery type; a second pair of terminals (202, 204) for electrically connecting to a battery powered device (10, 10') battery of the first type; a housing (110, 110') for supporting said first pair of terminals and said second pair of terminals; and an electronic circuit (300, 300') disposed in said housing (110, 110') and connected between said first (122, 124) and second (202, 204) pairs of terminals for controlling the charging of the battery powered device (10, 10') battery of the first type when the battery powered device is connected to said second pair of terminals and a battery charging device for a battery of the second battery type is connected to said first pair of terminals. a first pair of terminals (122, 124) in a configuration for electrically connecting to charging terminals of a charging device for a battery of the second battery type; a second pair of terminals (202, 204) for electrically connecting to a battery powered device (10, 10') battery of the first type; a housing (110, 110') for supporting said first pair of terminals and said second pair of terminals; and an electronic circuit (300, 300') disposed in said housing (110, 110') and connected between said first (122, 124) and second (202, 204) pairs of terminals for controlling the charging of the battery powered device (10, 10') battery of the first type when the battery powered device is connected to said second pair of terminals and a battery charging device for a battery of the second battery type is connected to said first pair of terminals.
A method for aligning two different images of the same subject, comprising the steps of: 1) identifying pairs of corresponding features in the two different images, and assigning transformation values to each of the pairs of corresponding features, the transformation values representing respective rigid transformations which bring the corresponding pair of features into alignment; 2) while the images are presented for display, computing a further rigid transformation for a current field of view as a rigid transformation in which the transformation values for a plurality of the pairs of corresponding features are weighted by respective computed weights; wherein in the computing step 2) the weights depend upon the position of the respective pairs of corresponding features in relation to the field of view, and a non-zero weight is given to transformation values for one or more pairs of corresponding features that are outside the current field of view; and 3) aligning the images in accordance with the further rigid transformation. 1) identifying pairs of corresponding features in the two different images, and assigning transformation values to each of the pairs of corresponding features, the transformation values representing respective rigid transformations which bring the corresponding pair of features into alignment; 2) while the images are presented for display, computing a further rigid transformation for a current field of view as a rigid transformation in which the transformation values for a plurality of the pairs of corresponding features are weighted by respective computed weights; wherein in the computing step 2) the weights depend upon the position of the respective pairs of corresponding features in relation to the field of view, and a non-zero weight is given to transformation values for one or more pairs of corresponding features that are outside the current field of view; and 3) aligning the images in accordance with the further rigid transformation.
Composition intended for protecting the skin and/or hair against ultraviolet radiation, characterized by the fact that it comprises, in a cosmetically acceptable support containing at least one aqueous phase, at least: (a) a photoprotective system capable of screening out UV radiation; (b) at least one gelling starch that is not modified by a chemical or physical process which is chosen from unmodified maize starches and (c) polyamide particles. (a) a photoprotective system capable of screening out UV radiation; (b) at least one gelling starch that is not modified by a chemical or physical process which is chosen from unmodified maize starches and (c) polyamide particles.
An ex vivo method for preparing a population comprising induced human paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing human pluripotent cells such as human embryonic stem cells or human iPS cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway, wherein the activator of said Wnt signaling pathway is a member of the R-spondin family or an inhibitor of GSK-3β.
A pharmaceutical formulation comprising: a pharmaceutically acceptable salt of omecamtiv mecarbil, or a pharmaceutically acceptable hydrate thereof; a control release agent; a pH modifying agent selected from the group consisting of fumaric acid, tartaric acid, glutamic acid, and any combination thereof; a filler; and a lubricant.
A pharmaceutical composition for use in treating cancer, comprising: an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier, wherein: the nanoparticles comprise gold; the anti-nucleolin agent comprises SEQ ID NO: 10; and the cancer is selected from the group consisting of melanoma, lymphoma, plasmocytoma, sarcoma, glioma, thymoma, leukemia, breast cancer, prostate cancer, colon cancer, liver cancer, esophageal cancer, brain cancer, lung cancer, ovary cancer, endometrial cancer, bladder cancer, kidney cancer, cervical cancer and hepatoma. an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier, wherein: the nanoparticles comprise gold; the anti-nucleolin agent comprises SEQ ID NO: 10; and the cancer is selected from the group consisting of melanoma, lymphoma, plasmocytoma, sarcoma, glioma, thymoma, leukemia, breast cancer, prostate cancer, colon cancer, liver cancer, esophageal cancer, brain cancer, lung cancer, ovary cancer, endometrial cancer, bladder cancer, kidney cancer, cervical cancer and hepatoma. the nanoparticles comprise gold; the anti-nucleolin agent comprises SEQ ID NO: 10; and the cancer is selected from the group consisting of melanoma, lymphoma, plasmocytoma, sarcoma, glioma, thymoma, leukemia, breast cancer, prostate cancer, colon cancer, liver cancer, esophageal cancer, brain cancer, lung cancer, ovary cancer, endometrial cancer, bladder cancer, kidney cancer, cervical cancer and hepatoma.
Process for starting a pump intended to pump a liquid contained in a tank and which is a solution of additive for injection into the exhaust line of an internal combustion engine, and to produce a substantially constant outlet pressure (setpoint pressure), according to which: 1. the temperature of the liquid held in the tank is determined and compared to a setpoint temperature; 2. if the temperature is greater than the setpoint temperature, the pump is actuated; 3. if the temperature is less than or equal to the setpoint temperature, the tank is heated for a time t1; then 4. the pump is actuated for a time t2 during which the pump outlet pressure is measured; 5. if this pressure is stable and in an acceptable margin of the setpoint pressure, the pump is kept going; 6. if this pressure is not stable and/or is not in the acceptable margin of the setpoint pressure, the pump is stopped and the tank is heated for a time t3, at the end of which steps 4 to 6 are repeated. 1. the temperature of the liquid held in the tank is determined and compared to a setpoint temperature; 2. if the temperature is greater than the setpoint temperature, the pump is actuated; 3. if the temperature is less than or equal to the setpoint temperature, the tank is heated for a time t1; then 4. the pump is actuated for a time t2 during which the pump outlet pressure is measured; 5. if this pressure is stable and in an acceptable margin of the setpoint pressure, the pump is kept going; 6. if this pressure is not stable and/or is not in the acceptable margin of the setpoint pressure, the pump is stopped and the tank is heated for a time t3, at the end of which steps 4 to 6 are repeated.
Herbicidal compositions comprising, as herbicidally active constituents, A) aclonifen (component A), B) pyroxasulfone (component B) and C) picolinafen (component C), comprising the respective herbicide components in the application rates stated below: component A: generally 10 - 5000 g of AS/ha, preferably 80 - 3000 g of AS/ha, particularly preferably 80 - 1000 g of AS/ha of aclonifen; component B: generally 10 - 300 g of AS/ha, preferably 25 - 100 g of AS/ha, particularly preferably 25 - 75 g of AS/ha of pyroxasulfone; component C: generally 1 - 500 g of AS/ha, preferably 10 - 300 g of AS/ha, particularly preferably 30 - 200 g of AS/ha of picolinafen. A) aclonifen (component A), B) pyroxasulfone (component B) and C) picolinafen (component C), component A: generally 10 - 5000 g of AS/ha, preferably 80 - 3000 g of AS/ha, particularly preferably 80 - 1000 g of AS/ha of aclonifen; component B: generally 10 - 300 g of AS/ha, preferably 25 - 100 g of AS/ha, particularly preferably 25 - 75 g of AS/ha of pyroxasulfone; component C: generally 1 - 500 g of AS/ha, preferably 10 - 300 g of AS/ha, particularly preferably 30 - 200 g of AS/ha of picolinafen.
A method for prognosing head-and-neck oral squamous cell cancer in a biological sample from a subject, comprising: detecting in the sample an overexpression of YWHAZ, wherein the biological sample has been derived from an oral tissue and wherein the overexpression of YWHAZ is associated with an adverse disease outcome. detecting in the sample an overexpression of YWHAZ, wherein the biological sample has been derived from an oral tissue and wherein the overexpression of YWHAZ is associated with an adverse disease outcome.
A positive electrode active material, comprising: a lithium-nickel based transition metal composite oxide having a layered structure, which is expressed by Chemical Formula 1 below; and a phosphate coated layer formed on the surface of the composite oxide, and wherein the content of nickel in the positive electrode active material is 70 mol% or more based on the total amount of metallic components excluding lithium, and wherein the phosphate coated layer comprises Li 3 PO 4 formed by reaction with lithium by-products present in the outer surface of the lithium-nickel based transition metal composite oxide: [Chemical Formula 1] Li x Ni a M b A w O 2-y D y where, 1.0≤x≤1.2, 0.7≤a≤1, 0<b≤0.3, 0≤y<0.2, 0<w≤0.3, and 2≤x+a+b+w≤2.2, M is Mn b1 Co b2, where, 0<b1+b2≤0.3, A is Sr, and D is at least one selected from the group consisting of S, N, F, Cl, Br, I, and P. a lithium-nickel based transition metal composite oxide having a layered structure, which is expressed by Chemical Formula 1 below; and a phosphate coated layer formed on the surface of the composite oxide, and wherein the content of nickel in the positive electrode active material is 70 mol% or more based on the total amount of metallic components excluding lithium, and wherein the phosphate coated layer comprises Li 3 PO 4 formed by reaction with lithium by-products present in the outer surface of the lithium-nickel based transition metal composite oxide: [Chemical Formula 1] Li x Ni a M b A w O 2-y D y where, 1.0≤x≤1.2, 0.7≤a≤1, 0<b≤0.3, 0≤y<0.2, 0<w≤0.3, and 2≤x+a+b+w≤2.2, M is Mn b1 Co b2, where, 0<b1+b2≤0.3, A is Sr, and D is at least one selected from the group consisting of S, N, F, Cl, Br, I, and P. where, 1.0≤x≤1.2, 0.7≤a≤1, 0<b≤0.3, 0≤y<0.2, 0<w≤0.3, and 2≤x+a+b+w≤2.2, M is Mn b1 Co b2, where, 0<b1+b2≤0.3, A is Sr, and D is at least one selected from the group consisting of S, N, F, Cl, Br, I, and P.
A method for allocating a connection identifier in a wireless communication system, the method comprising: defining, by a base station, a plurality of connection identifiers that are to be used for emergency call communication between the base station and a mobile station, and a plurality of burst profiles that are attributes related to wireless communication using the plurality of connection identifiers; broadcasting, from the base station to the mobile station, i) the plurality of connection identifiers and the plurality of burst profiles, or ii) the plurality of connection identifiers and the plurality of burst profiles and an indication of unused connection identifiers among the plurality of connection identifiers; and randomly selecting, by the mobile station, a connection identifier from the plurality of connection identifiers broadcast from the base station to the mobile station, wherein the randomly selected connection identifier is one of the unused connection identifiers when these are indicated in the broadcast from the base station. defining, by a base station, a plurality of connection identifiers that are to be used for emergency call communication between the base station and a mobile station, and a plurality of burst profiles that are attributes related to wireless communication using the plurality of connection identifiers; broadcasting, from the base station to the mobile station, i) the plurality of connection identifiers and the plurality of burst profiles, or ii) the plurality of connection identifiers and the plurality of burst profiles and an indication of unused connection identifiers among the plurality of connection identifiers; and i) the plurality of connection identifiers and the plurality of burst profiles, or ii) the plurality of connection identifiers and the plurality of burst profiles and an indication of unused connection identifiers among the plurality of connection identifiers; and randomly selecting, by the mobile station, a connection identifier from the plurality of connection identifiers broadcast from the base station to the mobile station, wherein the randomly selected connection identifier is one of the unused connection identifiers when these are indicated in the broadcast from the base station.
Batchwise process for aftertreatment of polyol esters prepared by reacting polyols of the general formula H-(-O-[-CR 1 R 2 -] m -) o -OH in which R 1 and R 2 are each independently hydrogen, an alkyl radical having 1 to 5 carbon atoms, preferably methyl, ethyl or propyl, or a hydroxyalkyl radical having 1 to 5 carbon atoms, preferably the hydroxymethyl radical, m is an integer from 1 to 10, preferably 1 to 8 and especially 1, 2, 3 or 4, o is an integer from 2 to 15, preferably 2 to 8 and especially 2, 3, 4 or 5, with excess linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms that have a lower boiling point than the polyols used, in the presence of a Lewis acid selected from the group of titanium, zirconium, hafnium, iron, zinc, boron, aluminum and tin as elements or in the form of compounds thereof as catalyst and in the presence of an adsorbent for sparingly soluble catalyst conversion products in an amount of 0.1 to 5, preferably 0.5 to 1.5, parts by weight per 100 parts by weight of a reaction mixture, while removing the water formed, characterized in that the excess monocarboxylic acid is removed by distillation and water is added to the crude ester obtained, at a temperature below the boiling point of water at the particular pressure and the crude ester with added water is aftertreated with avoidance of basic compounds, and the sparingly soluble conversion products and the adsorbent present in the esterification reaction are filtered off.