mhurhangee/ep-ind-claims huggingface dataset:
A process for determining the functionality of an artificial genetic element, wherein the process comprises the steps of a) providing a plurality of cells, wherein the cells comprise a native genetic element essential to propagation of said cells; b) introducing an artificial genetic element expected or designed to serve the same biological function as said native genetic element into said plurality of cells, in a transgenesis step; c) subjecting said plurality of cells to conditions of high frequency transposon mutagenesis in a mutagenesis step, wherein a transposable element may be inserted into said native genetic element and/or said artificial genetic element, and thereafter d) obtaining a set of DNA sequences, wherein each sequence is representative of a site of insertion of said transposable element from said plurality of cells; and e) determining the frequency of insertion of said transposable element into - said native genetic element and - said artificial genetic element f) comparing the frequency of transposon insertion into said native genetic element to the frequency of transposon insertion into said artificial genetic element and g) assigning a likelihood of functionality to said artificial functional element, which is - high if the frequency of transposon insertion is essentially equal for both elements, and - low if the frequency of transposon insertion is higher into the artificial genetic element. a) providing a plurality of cells, wherein the cells comprise a native genetic element essential to propagation of said cells; b) introducing an artificial genetic element expected or designed to serve the same biological function as said native genetic element into said plurality of cells, in a transgenesis step; c) subjecting said plurality of cells to conditions of high frequency transposon mutagenesis in a mutagenesis step, wherein a transposable element may be inserted into said native genetic element and/or said artificial genetic element, and thereafter d) obtaining a set of DNA sequences, wherein each sequence is representative of a site of insertion of said transposable element from said plurality of cells; and e) determining the frequency of insertion of said transposable element into - said native genetic element and - said artificial genetic element - said native genetic element and - said artificial genetic element f) comparing the frequency of transposon insertion into said native genetic element to the frequency of transposon insertion into said artificial genetic element and g) assigning a likelihood of functionality to said artificial functional element, which is - high if the frequency of transposon insertion is essentially equal for both elements, and - low if the frequency of transposon insertion is higher into the artificial genetic element. - high if the frequency of transposon insertion is essentially equal for both elements, and - low if the frequency of transposon insertion is higher into the artificial genetic element.
A lateral flow strip for detecting the amplified nucleic acid in an RPA reaction, the RPA reaction reagents comprising: a) at least one recombinase; b) at least one polymerase; c) dNTPs; d) a first and second nucleic acid primer; e) a third labelled 3' extension blocked primer which comprises a THF residue incorporated therein; and f) a nuclease wherein the first nucleic acid primer is labelled with a different label to the 3' extension blocked primer, and wherein the RPA reaction has been applied to the lateral flow strip. a) at least one recombinase; b) at least one polymerase; c) dNTPs; d) a first and second nucleic acid primer; e) a third labelled 3' extension blocked primer which comprises a THF residue incorporated therein; and f) a nuclease
A compound selected from the compounds having the following structure or a salt thereof: wherein R is -(CH 2) n -R X1; R X1 is: ∗ Denotes point of attachment of the R X1 group to (CH 2) n connecting group R X4 is a halogen selected from F, Cl, Br, I; n = 0-10; X is selected from the group consisting of -H, -OH, -OMe, -O-allyl, -F, -OEt, -OPr, - OCH 2 CH 2 OCH 3 and -azido; R' is selected from the group consisting of -Ac; -P(N(iPr) 2 (O(CH 2) 2)CN; -Bz and -SiMe 2 tBu; R" is selected from the group consisting of H, DMT and triphosphate (-P -OP -O-P 2) or a salt thereof. R is -(CH 2) n -R X1; R X1 is: ∗ Denotes point of attachment of the R X1 group to (CH 2) n connecting group R X4 is a halogen selected from F, Cl, Br, I; n = 0-10; X is selected from the group consisting of -H, -OH, -OMe, -O-allyl, -F, -OEt, -OPr, - OCH 2 CH 2 OCH 3 and -azido; R' is selected from the group consisting of -Ac; -P(N(iPr) 2 (O(CH 2) 2)CN; -Bz and -SiMe 2 tBu; R" is selected from the group consisting of H, DMT and triphosphate (-P -OP -O-P 2) or a salt thereof.
A bidirectional conversion apparatus adapted to be connected to a transmission line, said transmission line including a transmission electrical conductor connected to a base apparatus, said base apparatus being structured to perform modulation/demodulation, coding/decoding and to provide a first information signal and control signals (304, 303); said bidirectional conversion apparatus further being adapted to be connected to an antenna device, the bidirectional conversion apparatus being adapted to receive/transmit from/on the transmission line the first information signal and the control signals (304, 303) and being adapted to be external and remotely located with respect to the base apparatus and including: a tunable processing module (401-423, 425-440) configured to: - perform frequency translation and power shaping of the first information signal to obtain a second information signal and vice versa; the tunable processing module being configured to transmit/receive the second information signal toward/from the antenna device and perform the frequency translation wherein: the second information signal shows a corresponding frequency allocation higher than a frequency allocation of the first information signal and a corresponding bandwidth equal to a bandwidth of the first information signal; a control unit adapted to receive the control signals (303,304) from said remote base apparatus on said transmission line and send to the tunable processing module corresponding configuration signals setting operating behavior of the tunable processing module. a tunable processing module (401-423, 425-440) configured to: - perform frequency translation and power shaping of the first information signal to obtain a second information signal and vice versa; - perform frequency translation and power shaping of the first information signal to obtain a second information signal and vice versa; the tunable processing module being configured to transmit/receive the second information signal toward/from the antenna device and perform the frequency translation wherein: the second information signal shows a corresponding frequency allocation higher than a frequency allocation of the first information signal and a corresponding bandwidth equal to a bandwidth of the first information signal; a control unit adapted to receive the control signals (303,304) from said remote base apparatus on said transmission line and send to the tunable processing module corresponding configuration signals setting operating behavior of the tunable processing module. the second information signal shows a corresponding frequency allocation higher than a frequency allocation of the first information signal and a corresponding bandwidth equal to a bandwidth of the first information signal; a control unit adapted to receive the control signals (303,304) from said remote base apparatus on said transmission line and send to the tunable processing module corresponding configuration signals setting operating behavior of the tunable processing module.
A method of data channel transmission at a base station, comprising: allocating available base station power to a data channel for sending signals on the forward link, after base station power has been allocated to active channels for sending signals on the forward link; determining an amount of base station power allocated to the data channel; determining a total amount of base station power the data channel requires for forward link transmission; determining additional base station power the data channel requires as the total amount of base station power the data channel requires for forward link transmission less the allocated amount of base station power; selecting an active channel for base station power stealing based on a selection algorithm, the active channel being selected in response to the data channel requiring additional base station power; and stealing base station power from the selected active channel and using the stolen base station power for data channel transmission. allocating available base station power to a data channel for sending signals on the forward link, after base station power has been allocated to active channels for sending signals on the forward link; determining an amount of base station power allocated to the data channel; determining a total amount of base station power the data channel requires for forward link transmission; determining additional base station power the data channel requires as the total amount of base station power the data channel requires for forward link transmission less the allocated amount of base station power; selecting an active channel for base station power stealing based on a selection algorithm, the active channel being selected in response to the data channel requiring additional base station power; and stealing base station power from the selected active channel and using the stolen base station power for data channel transmission.
A controlled-release microsphere with a coating layer comprising a core comprising an exendin as an active ingredient, and a biodegradable polymer, and a coating layer that coats the core with a coating material, wherein the biodegradable polymer is a polymer selected from the group consisting of polylactide, polyglycolide, poly(lactide-co-glycolide) (PLGA), polyorthoester, polyanhydride, polyhydroxybutyric acid, polycaprolactone, and polyalkylcarbonate; a copolymer or a simple mixture of two or more selected from the polymer group; a copolymer of the polymer and polyethylenglycol; or a polymer-sugar complex where a sugar is coupled with the polymer or the copolymer, the coating material is one or more selected from the group consisting of basic amino acids, polypeptides, and organic nitrogen compounds, where the basic amino acid is one or more selected from the group consisting of arginine, lysine, and histidine, the polypeptide comprises 2 to 10 amino acids wherein one or more basic amino acids selected from the group consisting of arginine, lysine, and histidine are comprised, and the number of basic amino acid is more than that of acidic amino acids, and the organic nitrogen compound is one or more selected from the group consisting of creatine, creatinine, and urea.
A decorative element comprising a faceted transparent body having a front surface and a back surface, and a coating on at least part of the back surface of the faceted transparent body, wherein the coating comprises a reflective layer of semiconductor material and a layer of lacquer over the reflective layer such that the reflective layer lies in between the lacquer and the faceted transparent body, and wherein the reflective layer of semiconductor material has a thickness of at least 250 nm.
On-board electrical system for motor vehicles, in particular passenger cars, comprising a battery, comprising a generator which is provided for charging the battery, comprising at least one normal consumer which is connected to the battery in a switchable manner and comprising a DC voltage/DC voltage converter which, on a primary side, is connected to the battery and, on a secondary side, is connected to a high load resistor, for example a high-load actuator, so as to form an electrical subsystem with a storage means and such that it can be switched by means of a switch, wherein the switch connects the high-load consumer to the storage means and the secondary side in a first switching position and to the primary side in a second switching position, a controller is provided, which controller controls and operates the switching position of the switch between the first and the second switching position, a device for detecting the actual electrical power of the high-load consumer is provided, which device is associated with the high-load consumer and is connected at the output end to the controller, the controller positions the switch in the first switching position when the power requirement of the high-power consumer is less than 40 to 60% of the rated power of the high-power consumer, and positions it in the second switching position when the power requirement changes at least once by more than 10% of the rated power of the high-power consumer within one second.
A method for filling containers with rod-shaped articles, which is used in an apparatus comprising a hopper for feeding the articles, having at least two mouths for dispensing the articles through respective lower ends, conveyor means located in the vicinity of the at least two dispensing mouths and supporting a plurality of containers designed to receive inside the superposed layers of articles, extractor means for removing the articles from an unloading zone of each dispensing mouth and inserting them inside containers carried by the conveyor means, and an apparatus for dispensing containers designed to feed containers to be filled towards the conveyor means, characterised in that the conveyor means comprise two conveyors (17, 18) placed side by side and designed to operate independently on the containers each supported by the two conveyors of the conveyor means, and in that respective motor means (21, 22) are associated with the two conveyors (17, 18) for activating them independently so that one of the two conveyors (17, 18) moves towards the hopper the empty containers each carried on the two conveyors of the conveyor means from the dispensing apparatus, and the other of the two conveyors (17, 18) moves away from the hopper the containers full of rod-shaped articles and feeds them towards a further handling station.
A bottom housing assembly, comprising: an electric box; a base, wherein the base is provided with an installing end, the electric box is detachably installed on the installing end; and a pipe-layout structure formed between the installing end and the electric box, wherein the pipe-layout structure is used for leading a gas-liquid pipe out of the base; characterized in that the bottom housing assembly further comprises: a connecting column, the connecting column is disposed on the base, the electric box is connected with the base through the connecting column. an electric box; a base, wherein the base is provided with an installing end, the electric box is detachably installed on the installing end; and a pipe-layout structure formed between the installing end and the electric box, wherein the pipe-layout structure is used for leading a gas-liquid pipe out of the base; characterized in that the bottom housing assembly further comprises: a connecting column, the connecting column is disposed on the base, the electric box is connected with the base through the connecting column.
Compressed chewing gum tablet comprising one or more pharmaceutically active ingredients and one or more enhancers, the one or more enhancers comprising a pH control agent, wherein the chewing gum tablet comprises at least one chewing gum module comprising a chewing gum composition, and wherein the chewing gum composition comprises chewing gum granules containing gum base, wherein said one or more pharmaceutically active ingredients comprises nicotine, and wherein said pH control agent are at least partly contained within at least a part of said chewing gum granules.
A wetting composition comprising: (a) from 10 to less than 50 wt % of one or more C10-C14 alcohol; (b) 10 to 30 wt % of one or more C4-C6 oxygen containing co-solvent; (c) 20 to 60 wt % of one or more surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant; (d) 0 to 25 wt % water; and (e) 0 to 10 wt % other additives. (a) from 10 to less than 50 wt % of one or more C10-C14 alcohol; (b) 10 to 30 wt % of one or more C4-C6 oxygen containing co-solvent; (c) 20 to 60 wt % of one or more surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant; (d) 0 to 25 wt % water; and (e) 0 to 10 wt % other additives.
Machine for preparing beverages based upon an edible substance provided inside a portion package, presenting at least one extraction device adapted for interacting in proximity with the exterior envelope of said portion package, injecting a pressurized fluid flow and collecting the resulting beverage, and further presenting machine structural parts and fluid heating and compression means (51, 52) adapted for assembly by means of assembly connections, characterized in that said machine structural parts consist of: - a machine base part configured so as to serve as support to said extraction device and - a machine envelope part configured in form of convex shell, preferentially of box-like format, or similar, so as to confine said extraction device and fluid heating and compression means (51, 52) in its interior, whereby each of said machine structural parts is configured without zones with perforations, recessions or convexities developing along two or more different directions, whereby said machine structural parts (41, 42) are adapted for assembly to each other by means of assembly connections provided along a perimeter zone of said machine base part and for assembly of the functional components by means of assembly connections provided in said machine base part, and in that all assembly connections are provided so that they develop along a substantially vertical direction. - a machine base part configured so as to serve as support to said extraction device and - a machine envelope part configured in form of convex shell, preferentially of box-like format, or similar, so as to confine said extraction device and fluid heating and compression means (51, 52) in its interior,
An AC permanent magnet gain transformer device, consists of a rectangular closed-loop laminated iron core, primary windings (13, 14) and a secondary winding, wherein, said AC permanent magnet gain transformer device further includes a permanent magnet assembly, the said primary windings are respectively divided into L1 group and L2 group, and the L1 group and L2 group are respectively wound around the periphery of two vertical frameworks of the rectangular closed-loop laminated iron core; the said secondary winding is L, and L is wound around the periphery of the horizontal framework of the rectangular closed-loop laminated iron core; the number of the said permanent magnet assembly is two, the magnetic pole S and magnetic pole N of one first permanent magnet assembly are respectively cross over the primary winding L1, and wherein the magnetic pole S is connected with the vertical framework of the rectangular closed-loop laminated iron core above the primary winding L1, and the magnetic pole N is connected with the vertical framework of the rectangular closed-loop laminated iron core below the primary winding L1; similarly, the magnetic pole S and magnetic pole N of second permanent magnet assembly are respectively cross over the primary winding L2, and wherein the magnetic pole S is connected with the vertical framework of the rectangular closed-loop laminated iron core above the primary winding L2, and the magnetic pole N is connected with the vertical framework of the rectangular closed-loop laminated iron core below the primary winding L2; such that, the magnetic field direction of the first permanent magnet assembly is the same as the magnetic field direction of the primary winding L1 set up in parallel under electric excitation, and the magnetic field direction of the second permanent magnet assembly is the same as the magnetic field direction of the primary winding L2 set up in parallel under electric excitation, and such that in a same closed-loop magnetic loop, the direction of superimposed magnetic field generated under electric excitation by the first permanent magnet assembly and the primary winding L1 set up in parallel is opposite to the direction of superimposed magnetic field generated by the second permanent magnet assembly and the primary winding L2 set up in parallel.
A platform assembly for supporting a toy vehicle system to a substantially vertical tree trunk or post, having a centre clamp formed from at least two segments, which are joined together around the tree trunk or post, a plurality of brackets mounted on the centre clamp at one end and supporting a platform at the other end, characterised in that the centre clamp includes adjustment means to allow a user to adjust the pitch and roll of the platform relative to the tree or post.
A pesticidal composition comprising a carboxamide compound of formula and one or more azole compound(s) selected from propiconazole, prothioconazole, triadimenol, prochloraz, penconazole, tebuconazole, flusilazole, diniconazole, bromuconazole, epoxiconazole, difenoconazole, cyproconazole, metconazole, triflumizole, tetraconazole, myclobutanil, fenbuconazole, hexaconazole, fluquinconazole, triticonazole, bitertanol, imazilil, ipconazole, simeconazole, hymexazol, etridiazole and flutriafol.
Press seal for building up a sealing closure of a through-opening intersected by a line, having an elastomer body for contacting said line sealingly, a press plate and a tensioning bolt intersecting said elastomer body, wherein said press plate can be pressed by said tensioning bolt onto said elastomer body in such a way, that said elastomer body contacts said line sealingly, wherein a threaded portion of said tensioning bolt is screwed into a nut around a rotational axis, a section of said nut, which section lies proximal to said elastomer body, being held by a form-fit in a recess in said press plate and being secured against a rotational movement around said rotational axis thus, a section of said nut, which section lies distal to said elastomer body, comprising a flange which protrudes beyond said recess in directions perpendicular to said rotational axis outwards for transferring a force onto said press plate and pressing said press plate onto said elastomer body when said tensioning bolt is tensioned, wherein a front face of said press plate, which lies distal to said elastomer body, is even in its area region, namely apart from the edges, if appropriate, and said press plate is an even plate in its area region, namely apart from the edges, if appropriate.
A polyunsaturated substance for use in the treatment of Wet or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, Cataracts, or Stargardt Disease wherein the polyunsaturated substance comprises a fatty acid or fatty acid ester that is isotopically modified with deuterium at one or more positions; wherein the polyunsaturated substance is incorporated into a patient's body following administration; and wherein the amount of the isotopically modified fatty acid or fatty acid ester comprises between from 5% to 75% of the total amount of fatty acids or fatty acid esters administered to or ingested by the patient.