A multi-rotor aircraft with multi-shaft dislocation layout, comprising a frame, a plurality of upper-layer power sources and a same plurality of lower-layer power sources, the multi-rotor aircraft further comprising: a plurality of upper-layer propeller blades, the plurality of upper-layer propeller blades being disposed at intervals and being connected to the upper side of the frame through the plurality of upper-layer power sources on the upper side of the frame; and a plurality of lower-layer propeller blades, the plurality of lower-layer propeller blades being disposed at intervals and being connected to the lower side of the frame through the plurality of lower-layer power sources on the lower side of the frame; wherein the plurality of upper-layer propeller blades and the plurality of lower-layer propeller blades are staggered along a projection direction of the frame; the centers of the plurality of upper-layer propeller blades and the centers of the plurality of lower-layer propeller blades are axisymmetrically located on the same rectangle or ellipse along the horizontal projection direction of the frame; a lateral length of the multi-rotor aircraft is greater than a longitudinal length of the multi-rotor aircraft; and an overlap area between any adjacent upper-layer propeller blade and lower-layer propeller blade is equal to an axisymmetrically located overlap area between another adjacent upper-layer propeller blade and lower-layer propeller blade along the horizontal projection direction of the frame, so that a lift generated by any upper-layer propeller blade and the axisymmetrically located lower-layer propeller blade in a lift system of the multi-rotor aircraft is the same. a plurality of upper-layer propeller blades, the plurality of upper-layer propeller blades being disposed at intervals and being connected to the upper side of the frame through the plurality of upper-layer power sources on the upper side of the frame; and a plurality of lower-layer propeller blades, the plurality of lower-layer propeller blades being disposed at intervals and being connected to the lower side of the frame through the plurality of lower-layer power sources on the lower side of the frame; wherein the plurality of upper-layer propeller blades and the plurality of lower-layer propeller blades are staggered along a projection direction of the frame; the centers of the plurality of upper-layer propeller blades and the centers of the plurality of lower-layer propeller blades are axisymmetrically located on the same rectangle or ellipse along the horizontal projection direction of the frame; a lateral length of the multi-rotor aircraft is greater than a longitudinal length of the multi-rotor aircraft; and an overlap area between any adjacent upper-layer propeller blade and lower-layer propeller blade is equal to an axisymmetrically located overlap area between another adjacent upper-layer propeller blade and lower-layer propeller blade along the horizontal projection direction of the frame, so that a lift generated by any upper-layer propeller blade and the axisymmetrically located lower-layer propeller blade in a lift system of the multi-rotor aircraft is the same.