The compound of general formula wherein ring A is a cycloalkyl or heterocyclyl group; and in B-Y, Y is -O-, -C -, -CH 2 -, -NH-, -C 1-4 alkyl-N(R 18)- or bond and ring B is an optionally substituted heteroaryl, aryl or heterocyclyl group; or B-Y- jointly represents -N(C 1-4 alkyl) 2, C OC 1-4 alkyl, C 1-4 alkyl optionally substituted with halogen, C 1-4 alkoxy group or halogen; or B-Y-A- jointly represents a 3 H -spiro[2-benzofuran-1,4'-piperidin-1'-yl]; or R 1 is a hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, CF 3 or CN; R 2 is a hydrogen or C 1-4 alkyl group; R 3 is a NR 4 R 5, OR 6 group or halogen; or R 2 and R 3 jointly represent -O-(CH 2) m -O-, oxo or =N-OH group; R 4 and R 5 is independently a hydrogen; C 1-4 alkyl optionally substituted with OH, halogen, cycloalkyl, optionally substituted aryl or NR 8 R 9 group; Cy 1; C R 7; -S(O 2)R 10 or C 2-4 alkynyl group; or R 4 and R 5 taken together with the N to which they are attached form a heterocycle; R 6 is a hydrogen; C 1-4 alkyl optionally substituted with OH, halogen, Cy 2, C 1-4 alkoxy, -S 2 -C 1-4 alkyl or NR 11 R 12 group; C R 13; Si(CH 3) 2 - t -butyl or C 2-4 alkynyl group; R 7 is a C 1-4 alkyl optionally substituted with OH, CN, halogen, Cy 3 or NR 11 R 12 group; C 1-4 alkoxy, C 2-4 alkenyl, Cy 3 or N(C 1-4 alkyl) 2 group; R 8 and R 9 is independently a hydrogen, C 1-4 alkyl or C OR 21 group; R 10 is a C 1-4 alkyl, OH or NR 14 R 15 group; R 11 and R 12 is independently a hydrogen or C 1-4 alkyl group; or R 11 and R 12 taken together with the N to which they are attached form an optionally substituted heterocycle; R 13 is a C 1-4 alkyl optionally substituted with CN or NR 19 R 20 group; Cy 3 or NR 16 R 17 group; R 14 and R 15 is independently a hydrogen or C 1-4 alkyl group; R 16 and R 17 is independently a hydrogen, C 1-4 alkyl, or optionally substituted aryl group; or R 16 and R 17 taken together with the N to which they are attached form a heterocycle; R 18 and R 21 is a hydrogen or C 1-4 alkyl group; R 19 and R 20 is independently a hydrogen or C 1-4 alkyl group; Cy 1 is an optionally substituted cycloalkyl, heterocyclyl or heteroaryl group; Cy 2 is an optionally substituted aryl or cycloalkyl group; Cy 3 is an optinally substituted aryl, cycloalkyl, heterocyclyl or heteroaryl group; X is a C 1-4 alkyl, aryl or heteroaryl group; Z is a C 1-4 alkyl group; m is 2, 3, 4 or 5 and/or salts thereof and/or geometric isomers thereof and/or stereoisomers thereof and/or enantiomers thereof and/or racemates thereof and/or diastereomers thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof. ring A is a cycloalkyl or heterocyclyl group; and in B-Y, Y is -O-, -C -, -CH 2 -, -NH-, -C 1-4 alkyl-N(R 18)- or bond and ring B is an optionally substituted heteroaryl, aryl or heterocyclyl group; or B-Y- jointly represents -N(C 1-4 alkyl) 2, C OC 1-4 alkyl, C 1-4 alkyl optionally substituted with halogen, C 1-4 alkoxy group or halogen; or B-Y-A- jointly represents a 3 H -spiro[2-benzofuran-1,4'-piperidin-1'-yl]; or R 1 is a hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, CF 3 or CN; R 2 is a hydrogen or C 1-4 alkyl group; R 3 is a NR 4 R 5, OR 6 group or halogen; or R 2 and R 3 jointly represent -O-(CH 2) m -O-, oxo or =N-OH group; R 4 and R 5 is independently a hydrogen; C 1-4 alkyl optionally substituted with OH, halogen, cycloalkyl, optionally substituted aryl or NR 8 R 9 group; Cy 1; C R 7; -S(O 2)R 10 or C 2-4 alkynyl group; or R 4 and R 5 taken together with the N to which they are attached form a heterocycle; R 6 is a hydrogen; C 1-4 alkyl optionally substituted with OH, halogen, Cy 2, C 1-4 alkoxy, -S 2 -C 1-4 alkyl or NR 11 R 12 group; C R 13; Si(CH 3) 2 - t -butyl or C 2-4 alkynyl group; R 7 is a C 1-4 alkyl optionally substituted with OH, CN, halogen, Cy 3 or NR 11 R 12 group; C 1-4 alkoxy, C 2-4 alkenyl, Cy 3 or N(C 1-4 alkyl) 2 group; R 8 and R 9 is independently a hydrogen, C 1-4 alkyl or C OR 21 group; R 10 is a C 1-4 alkyl, OH or NR 14 R 15 group; R 11 and R 12 is independently a hydrogen or C 1-4 alkyl group; or R 11 and R 12 taken together with the N to which they are attached form an optionally substituted heterocycle; R 13 is a C 1-4 alkyl optionally substituted with CN or NR 19 R 20 group; Cy 3 or NR 16 R 17 group; R 14 and R 15 is independently a hydrogen or C 1-4 alkyl group; R 16 and R 17 is independently a hydrogen, C 1-4 alkyl, or optionally substituted aryl group; or R 16 and R 17 taken together with the N to which they are attached form a heterocycle; R 18 and R 21 is a hydrogen or C 1-4 alkyl group; R 19 and R 20 is independently a hydrogen or C 1-4 alkyl group; Cy 1 is an optionally substituted cycloalkyl, heterocyclyl or heteroaryl group; Cy 2 is an optionally substituted aryl or cycloalkyl group; Cy 3 is an optinally substituted aryl, cycloalkyl, heterocyclyl or heteroaryl group; X is a C 1-4 alkyl, aryl or heteroaryl group; Z is a C 1-4 alkyl group; m is 2, 3, 4 or 5 and/or salts thereof and/or geometric isomers thereof and/or stereoisomers thereof and/or enantiomers thereof and/or racemates thereof and/or diastereomers thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof.