A medical simulation system, comprising: a patient module that represents a human body, the patient module comprising: a fluid circuit, with at least one fluid sensor, coupleable to different types of therapeutic machines that include an extracorporeal membrane oxygenator ["ECMO"] machine, for interactively communicating a fluid therebetween; a patient display/delivery device coupled to the patient module; a computing device coupled to the patient module and the patient display/delivery device, the computing device comprising a processor and a memory that are coupled to each other and are configured to: interact with the patient module to simulate one or more vital signs of the patient module as the patient module interacts with at least one of the different types of therapeutic machines; and receive physical data of at least one measured pressure of the fluid from the sensor in the fluid circuit of the patient module and provide instructions to the patient module to implement a clinical scenario; generate at least one simulated pressure signal to control a physical component in the fluid circuit based on the measured pressure for the patient module interacting with the at least one of the different types of therapeutic machines, to display on the patient display/ delivery device; and wherein: the computing device contains a superset of programming capability for one or more different types of therapeutic machines; and the medical simulation system simulates the clinical scenario of the human body according to a degree of a pathological condition of at least one system of the human body. a patient module that represents a human body, the patient module comprising: a fluid circuit, with at least one fluid sensor, coupleable to different types of therapeutic machines that include an extracorporeal membrane oxygenator ["ECMO"] machine, for interactively communicating a fluid therebetween; a fluid circuit, with at least one fluid sensor, coupleable to different types of therapeutic machines that include an extracorporeal membrane oxygenator ["ECMO"] machine, for interactively communicating a fluid therebetween; a patient display/delivery device coupled to the patient module; a computing device coupled to the patient module and the patient display/delivery device, the computing device comprising a processor and a memory that are coupled to each other and are configured to: interact with the patient module to simulate one or more vital signs of the patient module as the patient module interacts with at least one of the different types of therapeutic machines; and receive physical data of at least one measured pressure of the fluid from the sensor in the fluid circuit of the patient module and provide instructions to the patient module to implement a clinical scenario; generate at least one simulated pressure signal to control a physical component in the fluid circuit based on the measured pressure for the patient module interacting with the at least one of the different types of therapeutic machines, to display on the patient display/ delivery device; and wherein: the computing device contains a superset of programming capability for one or more different types of therapeutic machines; and the medical simulation system simulates the clinical scenario of the human body according to a degree of a pathological condition of at least one system of the human body. interact with the patient module to simulate one or more vital signs of the patient module as the patient module interacts with at least one of the different types of therapeutic machines; and receive physical data of at least one measured pressure of the fluid from the sensor in the fluid circuit of the patient module and provide instructions to the patient module to implement a clinical scenario; generate at least one simulated pressure signal to control a physical component in the fluid circuit based on the measured pressure for the patient module interacting with the at least one of the different types of therapeutic machines, to display on the patient display/ delivery device; and wherein: the computing device contains a superset of programming capability for one or more different types of therapeutic machines; and the computing device contains a superset of programming capability for one or more different types of therapeutic machines; and the medical simulation system simulates the clinical scenario of the human body according to a degree of a pathological condition of at least one system of the human body.