A braking system for motorcycles comprising - a first manual actuator device, operable by means of a lever and / or a pedal, selectively connectable to at least a first braking device placed on a front axle of the vehicle, and/or at least a second braking device placed on said front axle or on a rear axle of the motorcycle, each braking device acting on a relative brake disc or drum, - the first manual actuator device being provided with a hydraulic supply circuit that can be selectively connected to a hydraulic input circuit of at least one of said braking devices (12,20) by means of a control valve, said control valve being positioned in an operating position, in which it hydraulically disconnects the first manual actuator device from the braking devices (12,20), and in an electrical fault position, in which it hydraulically connects the first manual actuator device with at least one of said braking devices (12,20), - at least one electro-hydraulic automatic actuator device fluidly connectable to the hydraulic input circuit of at least one of said braking devices (12, 20) for the respective hydraulic actuation thereof, - at least one electromechanical automatic actuator device associated with at least one of said braking devices (12, 20) not provided with a hydraulic input circuit, - the electro-hydraulic automatic actuator devices being associated with the front axle and the electromechanical automatic actuator devices being associated with the rear axle of the motorcycle or vice versa, characterized by - a single control unit operatively connected to the control valve, to the at least one electro-hydraulic automatic actuator device, to the at least one electromechanical automatic actuator device and to the first manual actuator device so as to operate said electro-hydraulic and electromechanical automatic actuator devices and said control valve according to the position or configuration of the first manual actuator device and/or according to the dynamics of the motorcycle. - a first manual actuator device, operable by means of a lever and / or a pedal, selectively connectable to at least a first braking device placed on a front axle of the vehicle, and/or at least a second braking device placed on said front axle or on a rear axle of the motorcycle, each braking device acting on a relative brake disc or drum, - the first manual actuator device being provided with a hydraulic supply circuit that can be selectively connected to a hydraulic input circuit of at least one of said braking devices (12,20) by means of a control valve, said control valve being positioned in an operating position, in which it hydraulically disconnects the first manual actuator device from the braking devices (12,20), and in an electrical fault position, in which it hydraulically connects the first manual actuator device with at least one of said braking devices (12,20), - at least one electro-hydraulic automatic actuator device fluidly connectable to the hydraulic input circuit of at least one of said braking devices (12, 20) for the respective hydraulic actuation thereof, - at least one electromechanical automatic actuator device associated with at least one of said braking devices (12, 20) not provided with a hydraulic input circuit, - the electro-hydraulic automatic actuator devices being associated with the front axle and the electromechanical automatic actuator devices being associated with the rear axle of the motorcycle or vice versa, characterized by - a single control unit operatively connected to the control valve, to the at least one electro-hydraulic automatic actuator device, to the at least one electromechanical automatic actuator device and to the first manual actuator device so as to operate said electro-hydraulic and electromechanical automatic actuator devices and said control valve according to the position or configuration of the first manual actuator device and/or according to the dynamics of the motorcycle.