mhurhangee/ep-ind-claims huggingface dataset:
Use of a composition comprising: at least one of an α 2 adrenergic receptor agonist and a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier for the preparation of a medicament for treating rosacea, wherein said composition is to be topically applied directly to the affected area of skin of a patient in need of such treatment to decrease blood flow through the small arteries or arterioles of the skin of the patient, and wherein said composition acts locally in the skin of the patient, wherein the at least one of an α 2 adrenergic receptor agonist and a pharmaceutically acceptable salt thereof is selected from the group consisting of brimonidine, naphazoline, oxymetazoline, xylometazoline, epinephrine, norepinephrine, phenylephrine, and methoxamine. at least one of an α 2 adrenergic receptor agonist and a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier for the preparation of a medicament for treating rosacea, wherein said composition is to be topically applied directly to the affected area of skin of a patient in need of such treatment to decrease blood flow through the small arteries or arterioles of the skin of the patient, and wherein said composition acts locally in the skin of the patient, wherein the at least one of an α 2 adrenergic receptor agonist and a pharmaceutically acceptable salt thereof is selected from the group consisting of brimonidine, naphazoline, oxymetazoline, xylometazoline, epinephrine, norepinephrine, phenylephrine, and methoxamine.
An eductor system for an auxiliary power unit, comprising: an eductor housing defining a primary plenum with an inlet opening and an exit opening, wherein the primary plenum is disposed around a longitudinal axis and is configured to channel a first flow stream from the inlet opening to the exit opening, and the eductor housing defines a secondary plenum with a duct inlet and a number of exit slots, the secondary plenum separated from the primary plenum and configured to channel a second flow stream from the duct inlet to the exit slots; a nozzle through which a gas flow stream is delivered into the eductor housing, the gas flow stream directed through the exit opening so that the gas flow stream educes the first flow stream through the inlet opening and the exit opening; and characterised by further comprising a duct connected with the secondary plenum at the duct inlet, and through which the second flow stream is delivered to the secondary plenum, the duct connected to the secondary plenum at an angle so that the second flow stream is directed away from the longitudinal axis, wherein the duct is configured with the angle to induce a swirl of the second flow stream to effect a static pressure at the exit opening that draws the first flow stream through the exit opening. an eductor housing defining a primary plenum with an inlet opening and an exit opening, wherein the primary plenum is disposed around a longitudinal axis and is configured to channel a first flow stream from the inlet opening to the exit opening, and the eductor housing defines a secondary plenum with a duct inlet and a number of exit slots, the secondary plenum separated from the primary plenum and configured to channel a second flow stream from the duct inlet to the exit slots; a nozzle through which a gas flow stream is delivered into the eductor housing, the gas flow stream directed through the exit opening so that the gas flow stream educes the first flow stream through the inlet opening and the exit opening; and characterised by further comprising a duct connected with the secondary plenum at the duct inlet, and through which the second flow stream is delivered to the secondary plenum, the duct connected to the secondary plenum at an angle so that the second flow stream is directed away from the longitudinal axis, wherein the duct is configured with the angle to induce a swirl of the second flow stream to effect a static pressure at the exit opening that draws the first flow stream through the exit opening.
System for recording intracardiac signals and for providing stimulation pulses and/or ablation energy at intracardiac locations, the system comprising: - a plurality of intracardiac terminals (10a-d) adapted to collecting intracardiac electrophysiological potentials from a plurality of passive intracardiac electrodes (1a-d) at respective intracardiac locations in an individual; - an indifferent terminal adapted to collecting indifferent electrophysiological potentials from one or more indifferent electrodes in or on the individual; - a differential amplifier stage adapted to receiving and amplifying the electrophysiological potentials collected from the intracardiac and indifferent terminals (10a-d, 20) with respect to a signal reference to obtain respective intracardiac and indifferent signals (201a-d, 202); and - a processor device 40 adapted to determining a common mode signal as an average of the intracardiac and indifferent signals (201a-d, 202) and adapted to providing an output of intracardiac data based at least on the intracardiac signals (201a-d), wherein the intracardiac signals (201a-d) are referenced with respect to the common mode signal. - a plurality of intracardiac terminals (10a-d) adapted to collecting intracardiac electrophysiological potentials from a plurality of passive intracardiac electrodes (1a-d) at respective intracardiac locations in an individual; - an indifferent terminal adapted to collecting indifferent electrophysiological potentials from one or more indifferent electrodes in or on the individual; - a differential amplifier stage adapted to receiving and amplifying the electrophysiological potentials collected from the intracardiac and indifferent terminals (10a-d, 20) with respect to a signal reference to obtain respective intracardiac and indifferent signals (201a-d, 202); and - a processor device 40 adapted to determining a common mode signal as an average of the intracardiac and indifferent signals (201a-d, 202) and adapted to providing an output of intracardiac data based at least on the intracardiac signals (201a-d), wherein the intracardiac signals (201a-d) are referenced with respect to the common mode signal.
Substituted 2-amino-3-sulfonyl-pyrazolo[1,5-a]pyrimidines of general formula 1 or pharmaceutically acceptable salts and/or hydrates thereof, wherein: Ar represents optionally substituted aryl or optionally substituted heterocyclyl; R 1 and R 3 independently of each other represent C 1 -C 3 alkyl or phenyl; R 2 represents hydrogen or C 1 -C 3 alkyl; R 4 1, R 4 2 independently of each other represent hydrogen, optionally substituted C 1 -C 3 alkyl or optionally substituted phenyl, or R 4 1 and R 4 2 together with the nitrogen atom to which they are attached form optionally substituted heterocyclyl, wherein heterocyclyl means an aromatic or nonaromatic monocyclic or polycyclic system comprising 3 - 10 carbon atoms, in which one or more carbon atoms are replaced by nitrogen, oxygen, or sulfur and wherein N- and S-atoms of heterocyclic fragment could be oxidized to N-oxide, S-oxide and S-dioxide. Ar represents optionally substituted aryl or optionally substituted heterocyclyl; R 1 and R 3 independently of each other represent C 1 -C 3 alkyl or phenyl; R 2 represents hydrogen or C 1 -C 3 alkyl; R 4 1, R 4 2 independently of each other represent hydrogen, optionally substituted C 1 -C 3 alkyl or optionally substituted phenyl, or R 4 1 and R 4 2 together with the nitrogen atom to which they are attached form optionally substituted heterocyclyl, wherein heterocyclyl means an aromatic or nonaromatic monocyclic or polycyclic system comprising 3 - 10 carbon atoms, in which one or more carbon atoms are replaced by nitrogen, oxygen, or sulfur and wherein N- and S-atoms of heterocyclic fragment could be oxidized to N-oxide, S-oxide and S-dioxide.
An absorbent article comprising an absorber composed of at least one absorbent layer (1, 6), wherein a water-absorbent resin powder meeting the following requirements (a) to (d) is disposed in an uppermost layer of the absorber: (a) a bulk density: 0.45 g/ml to 0.62 g/ml; (b) an absorption speed by a vortex method: 20 seconds to 50 seconds; (c) a liquid-passing speed under load: 10 seconds or less; and (d) a moisture absorption blocking ratio: 5% or less, wherein the water-absorbent resin powder is obtained by treating, with a surface modifier, a crosslinked polymer obtained by polymerizing a monomer composition containing: a water-soluble ethylenically unsaturated monomer and/or a hydrolyzable monomer producing the water-soluble ethylenically unsaturated monomer by hydrolysis; and an internal crosslinking agent (b), and wherein the surface modifier is at least one member selected from the group consisting of polydimethylsiloxane, polyether-modified polysiloxanes, carboxy-modified polysiloxanes, epoxy-modified polysiloxanes, amino-modified polysiloxanes, and alkoxy-modified polysiloxanes. (a) a bulk density: 0.45 g/ml to 0.62 g/ml; (b) an absorption speed by a vortex method: 20 seconds to 50 seconds; (c) a liquid-passing speed under load: 10 seconds or less; and (d) a moisture absorption blocking ratio: 5% or less,
A vector for use in treating macular degeneration or glaucoma, wherein said vector is useful for conditionally expressing protein(s) having the function(s) of one or more therapeutic protein(s) comprising a polynucleotide encoding a gene switch, wherein said polynucleotide comprises at least one transcription factor sequence which is operably linked to a promoter, wherein said at least one transcription factor sequence encodes a ligand-dependent transcription factor, and a polynucleotide encoding at least one therapeutic protein operably linked to a promoter which is activated by said ligand-dependent transcription factor, wherein the therapeutic protein is selected from the group consisting of: Vascular Endothelial Growth Factor (VEGF) decoy, Pigment Derived Growth Factor (PDGF), Endostatin, Angiostatin, Angiopoietin-1, and ATP Binding Cassette Subfamily A Member 4; and wherein said vector is not contained within a cell prior to in vivo administration.
Pyrotechnic circuit breaker comprising: - a housing, - at least two connection terminals (21, 22), - an internal electrical circuit connecting the two connection terminals (21, 22) and formed, for example, by an electrical conductor, - an opening member which is movable and arranged to open a part to be opened of the internal electrical circuit when moving between an initial position and a final position, so as to form at least two separate conductor portions (32, 33) after opening, - a pyrotechnic actuator arranged to move the opening member from the initial position to the final position, - an internal chamber receiving the part to be opened, characterized in that the internal chamber comprises or contains at least one wall formed with a plastics material comprising silicone. - a housing, - at least two connection terminals (21, 22), - an internal electrical circuit connecting the two connection terminals (21, 22) and formed, for example, by an electrical conductor, - an opening member which is movable and arranged to open a part to be opened of the internal electrical circuit when moving between an initial position and a final position, so as to form at least two separate conductor portions (32, 33) after opening, - a pyrotechnic actuator arranged to move the opening member from the initial position to the final position, - an internal chamber receiving the part to be opened,
A system for underground power generation, the system comprising a thermoelectric generator rod, comprising: a sensor; a first thermal contact for making contact with soil; a second thermal contact for making contact with soil; a thermoelectric generator having: a first heat exchange surface; a second heat exchange surface; a first electrical contact; and a second electrical contact; a first thermally conductive member connecting the first thermal contact to the first heat exchange surface; and a second thermally conductive member connecting the second thermal contact to the second heat exchange surface; a processing unit; the thermoelectric generator being configured to provide electrical power at the first electrical contact and the second electrical contact in response to a difference between a temperature at the first heat exchange surface and the second heat exchange surface, the processing unit being configured to receive electrical power produced by the thermoelectric generator, the system being installed underground, with the first thermal contact in contact with soil at a first depth, and the second thermal contact in contact with soil at a second depth, the second depth differing from the first depth by at least 122 cm (48 inches). a sensor; a first thermal contact for making contact with soil; a second thermal contact for making contact with soil; a thermoelectric generator having: a first heat exchange surface; a second heat exchange surface; a first electrical contact; and a second electrical contact; a first heat exchange surface; a second heat exchange surface; a first electrical contact; and a second electrical contact; a first thermally conductive member connecting the first thermal contact to the first heat exchange surface; and a second thermally conductive member connecting the second thermal contact to the second heat exchange surface; a processing unit; the thermoelectric generator being configured to provide electrical power at the first electrical contact and the second electrical contact in response to a difference between a temperature at the first heat exchange surface and the second heat exchange surface, the processing unit being configured to receive electrical power produced by the thermoelectric generator, the system being installed underground, with the first thermal contact in contact with soil at a first depth, and the second thermal contact in contact with soil at a second depth, the second depth differing from the first depth by at least 122 cm (48 inches).
A method of searching electronic program guide data, comprising: receiving a text search string by way of a search string receiver, wherein the text search string contains one or more text terms and one or more attribute terms; normalizing the text search string to make searchable terms by: applying spell checking to the text search string, identifying a word as being misspelled, and appending a corrected form of the word identified as being misspelled to the searchable terms to conduct a conditional search based on the corrected form of the word; separating the searchable terms into text terms and attribute terms by way of a string interpreter (214, 304), the string interpreter (214, 304) parsing the text search string to separate the searchable terms into the text terms and the attribute terms by comparing the searchable terms with a list of attributes for identifying the attribute terms; performing a text search in the EPG data for each text term; performing an attribute search in the EPG data for each attribute term; and ranking results from the text and attribute searches for displaying search results conforming to the text search string, the ranking comprising lowering a relevancy ranking of hits resulting from the conditional search on the corrected form of the word when search results are obtained based on the word identified as misspelled. receiving a text search string by way of a search string receiver, wherein the text search string contains one or more text terms and one or more attribute terms; normalizing the text search string to make searchable terms by: applying spell checking to the text search string, identifying a word as being misspelled, and appending a corrected form of the word identified as being misspelled to the searchable terms to conduct a conditional search based on the corrected form of the word; applying spell checking to the text search string, identifying a word as being misspelled, and appending a corrected form of the word identified as being misspelled to the searchable terms to conduct a conditional search based on the corrected form of the word; separating the searchable terms into text terms and attribute terms by way of a string interpreter (214, 304), the string interpreter (214, 304) parsing the text search string to separate the searchable terms into the text terms and the attribute terms by comparing the searchable terms with a list of attributes for identifying the attribute terms; performing a text search in the EPG data for each text term; performing an attribute search in the EPG data for each attribute term; and ranking results from the text and attribute searches for displaying search results conforming to the text search string, the ranking comprising lowering a relevancy ranking of hits resulting from the conditional search on the corrected form of the word when search results are obtained based on the word identified as misspelled.
A dart game apparatus comprising: a dart target having a plurality of score areas; a sensing unit configured to sense a hit location of a dart pin in the dart target; a display unit providing a display area surrounding the dart target, provided in a body structure of the dart game apparatus, and configured to output a changeable image, comprising a touch sensor to detect at least one of a touch pressure, a touched position and a touched area in the display unit; and a controller configured to control the display unit at least partially based on the hit location of the dart pin in the dart target; a cover protecting the display unit and at least partly made of a material having optical transmittance, said cover being positioned between the display unit and a throw line; whereby said cover is positioned at a distance from the display unit, and whereby a receiving groove or an opening is present in the cover and the dart target is positioned in said receiving groove or in said opening. a dart target having a plurality of score areas; a sensing unit configured to sense a hit location of a dart pin in the dart target; a display unit providing a display area surrounding the dart target, provided in a body structure of the dart game apparatus, and configured to output a changeable image, comprising a touch sensor to detect at least one of a touch pressure, a touched position and a touched area in the display unit; and a controller configured to control the display unit at least partially based on the hit location of the dart pin in the dart target; a cover protecting the display unit and at least partly made of a material having optical transmittance, said cover being positioned between the display unit and a throw line; whereby said cover is positioned at a distance from the display unit, and whereby a receiving groove or an opening is present in the cover and the dart target is positioned in said receiving groove or in said opening.
Device for the cryogenic separation of air, with a main heat exchanger, with a distillation column system for nitrogen-oxygen separation, which has a double column, which comprises a high-pressure column and a low-pressure column, with a mixing column and with means for introducing feed air via the main heat exchanger into the high-pressure column and into the mixing column, with a liquid oxygen line for introducing liquid oxygen from the low-pressure column into the upper region of the mixing column, and with an oxygen product line for extracting oxygen gas from the upper region of the mixing column through the main heat exchanger, wherein the mixing column is arranged laterally alongside the double column, characterized in that the mixing column and the double column are arranged in a common cold box and in that the mixing column is attached laterally to the double column by way of connecting elements (10, 11), wherein the mixing column is supported on the double column by way of the connecting elements (10, 11).
A household appliance (1; 14; 17) comprising a heat pump, the heat pump comprising a compressor, a condenser, an expansion device, and an evaporator, characterized in that the household appliance further comprises at least one refrigerant redirection device (8, 9; 15, 16; 18-21) to locally reverse a flow direction of a refrigerant only through the condenser and/or through the evaporator wherein locally reversing the flow direction of the refrigerant only through the condenser and/or through the evaporator includes only reversing the use of ports (CP1, CP2, EP1, EP2) of the condenser and/or the evaporator as inlet and outlet ports, and wherein when locally reversing the flow direction of the refrigerant, a function of the evaporator and/or a function of the condenser remain the same.
A crystalline form (Form 1) of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole, wherein said crystalline form has a powder X-ray diffraction pattern which comprises peaks at a diffraction angle (2θ) of 15.4 ± 0.2, 20.2 ± 0.2, 28.6 ± 0.2 and 29.0 ± 0.2 and wherein said crystalline form has a solid state NMR spectrum comprising 13C chemical shifts (ppm) at 120.8 ± 0.2 and 127.7 ± 0.2, for use as a medicament.
A blowout preventer comprising: a. a body comprising a bore therethrough; b. a cavity disposed through the body and intersecting the bore; c. first and second closure members moveably disposed within the cavity on opposite sides of the bore; d. a first rod having a length and comprising a first end coupled to the first closure member; e. a second rod having a length and comprising a first end coupled to the second closure member; f. a first glider assembly wherein a second end of the first rod is at least partially disposed within the first glider assembly; and g. a second glider assembly wherein a second end of the second rod is at least partially disposed within the second glider assembly; wherein the first and second rods have magnets (28,38) along at least a portion of the length of each rod; the first and second glider assemblies are located on opposite sides of the bore; and the first and second glider assemblies each comprise means for generating an electromagnetic field; characterized in that the second end (25,35) of the first and second rods is connected to separate sets of conductive rails that are operated as a railgun to propel the first and second rods toward the center of the bore. a. a body comprising a bore therethrough; b. a cavity disposed through the body and intersecting the bore; c. first and second closure members moveably disposed within the cavity on opposite sides of the bore; d. a first rod having a length and comprising a first end coupled to the first closure member; e. a second rod having a length and comprising a first end coupled to the second closure member; f. a first glider assembly wherein a second end of the first rod is at least partially disposed within the first glider assembly; and g. a second glider assembly wherein a second end of the second rod is at least partially disposed within the second glider assembly; wherein the first and second rods have magnets (28,38) along at least a portion of the length of each rod; the first and second glider assemblies are located on opposite sides of the bore; and the first and second glider assemblies each comprise means for generating an electromagnetic field; characterized in that the second end (25,35) of the first and second rods is connected to separate sets of conductive rails that are operated as a railgun to propel the first and second rods toward the center of the bore.
A connecting device with a plug, which is configured in order to establish an electrical connection to a mating plug, wherein the connecting device has a cable feedthrough and a plug holder, in which the plug is detachably held, wherein the plug holder is designed so as to be elastic in the plug-in direction of the plug, characterized in that the plug holder can be moved in the cable feedthrough in the plug-in direction.