mhurhangee/ep-ind-claims huggingface dataset:
A frame assembly comprising: a bottom support structure having a front side and a back side; a handle housing having a top end and a bottom end, the bottom end being coupled to the bottom support structure at the back side thereof; a holder coupled to the top end of the handle housing; and a diagonal support structure diagonally positioned and coupled to the handle housing via the holder and coupled to the bottom support structure at the front side thereof, wherein the bottom support structure includes at least one curved portion and a flat portion, the curved portion is configured to couple to a wheel assembly (113a, 113b, 115a, 115b), characterized in that the flat portion is configured to be positioned closer to a floor surface than the curved portion. a bottom support structure having a front side and a back side; a handle housing having a top end and a bottom end, the bottom end being coupled to the bottom support structure at the back side thereof; a holder coupled to the top end of the handle housing; and a diagonal support structure diagonally positioned and coupled to the handle housing via the holder and coupled to the bottom support structure at the front side thereof, wherein the bottom support structure includes at least one curved portion and a flat portion, the curved portion is configured to couple to a wheel assembly (113a, 113b, 115a, 115b), characterized in that the flat portion is configured to be positioned closer to a floor surface than the curved portion.
Stack protection for the manual protection of stacked timber - such as especially firewood, delimbed stems, short logs or sawn timber - from rain and impacts of weather while stored outdoors, wherein the stack protection comprises: - an upper part in the shape of an oblong strip, which upper part comprises tarpaulin or consists of tarpaulin; - side parts in the shape of an oblong strip, which side parts are fastened to both side edges (2A, 2B) of the upper part, which side parts comprise a protective net or consist of a protective net; - fastening means arranged in both side parts for anchoring the stack protection characterized in that the side parts which are fastened to both the side edges (2A, 2B) of the upper part are shorter than said side edges. - such as especially firewood, delimbed stems, short logs or sawn timber - from rain and impacts of weather while stored outdoors, - an upper part in the shape of an oblong strip, which upper part comprises tarpaulin or consists of tarpaulin; - side parts in the shape of an oblong strip, which side parts are fastened to both side edges (2A, 2B) of the upper part, which side parts comprise a protective net or consist of a protective net; - fastening means arranged in both side parts for anchoring the stack protection characterized in that
Method for screening hypoallergen candidates for immunotherapy comprising the steps of: a) altering the surface area of an allergenic polypeptide selected from the group consisting of: Api m 1 and Api m 4, wherein said surface area is a monomer-monomer interface with an area less than 850 Å 2 related to the formation of dimers in order to inactivate or reduce the polypeptide's natural ability to form dimers, wherein the surface area of said polypeptide related to the formation of dimers is altered by directed mutagenesis of the nucleic acid encoding said polypeptide to produce amino acid substitutions to said polypeptide; b) testing in vitro the altered polypeptide obtained from step a) for ability to activate release of histamine or other mediators of an allergic reactions from human basophilic leukocytes or mast cells, wherein those altered polypeptides which do not activate histamine release or said other mediators or activate histamine release or said other mediators less than the parent polypeptide are considered as hypoallergen candidates for immunotherapy; and c) checking in vitro that a IgE antibody specific to said allergenic polypeptide still binds to the altered polypeptide obtained from step a) and tested in step b) to confirm that said altered polypeptide has a native-like structure, capability to prevent the crosslinking of the IgE-FcεRI complexes on a mast cell or basophile surface antibodies and immunogenic potential to develop protective IgG antibodies. a) altering the surface area of an allergenic polypeptide selected from the group consisting of: Api m 1 and Api m 4, wherein said surface area is a monomer-monomer interface with an area less than 850 Å 2 related to the formation of dimers in order to inactivate or reduce the polypeptide's natural ability to form dimers, wherein the surface area of said polypeptide related to the formation of dimers is altered by directed mutagenesis of the nucleic acid encoding said polypeptide to produce amino acid substitutions to said polypeptide; b) testing in vitro the altered polypeptide obtained from step a) for ability to activate release of histamine or other mediators of an allergic reactions from human basophilic leukocytes or mast cells, wherein those altered polypeptides which do not activate histamine release or said other mediators or activate histamine release or said other mediators less than the parent polypeptide are considered as hypoallergen candidates for immunotherapy; and c) checking in vitro that a IgE antibody specific to said allergenic polypeptide still binds to the altered polypeptide obtained from step a) and tested in step b) to confirm that said altered polypeptide has a native-like structure, capability to prevent the crosslinking of the IgE-FcεRI complexes on a mast cell or basophile surface antibodies and immunogenic potential to develop protective IgG antibodies.
A method implemented by a node of a network domain having a plurality of nodes, where the node functions as an ingress node of the network domain for a data flow, the method to enable data flow analysis across the network domain, the method comprising the steps of: receiving plural data packets belonging to a data flow at an ingress node of the network domain; determining a data packet to be marked for the data flow analysis from among the plural data packets; determining that an egress node of the network domain for the data flow supports data packet marking; marking, in response to determining that the egress node supports data packet marking, the data packet that is determined to be marked for data flow analysis with a marking label indicating to supporting nodes in the network domain that the marked data packet is to be processed for data flow analysis; and forwarding the plural data packets toward the egress node of the network domain. receiving plural data packets belonging to a data flow at an ingress node of the network domain; determining a data packet to be marked for the data flow analysis from among the plural data packets; determining that an egress node of the network domain for the data flow supports data packet marking; marking, in response to determining that the egress node supports data packet marking, the data packet that is determined to be marked for data flow analysis with a marking label indicating to supporting nodes in the network domain that the marked data packet is to be processed for data flow analysis; and forwarding the plural data packets toward the egress node of the network domain.
An abrasive braze preform comprising: a self-braze layer comprising a sintered sheet of: at least one first alloy of low melting point relative to a substrate to which the preform is to be applied; and at least one second alloy of high melting point relative to the first alloy; an intermediate layer secured to the self-braze layer; and a matrix bonded to the intermediate layer and at least partially embedding an abrasive. a self-braze layer comprising a sintered sheet of: at least one first alloy of low melting point relative to a substrate to which the preform is to be applied; and at least one second alloy of high melting point relative to the first alloy; at least one first alloy of low melting point relative to a substrate to which the preform is to be applied; and at least one second alloy of high melting point relative to the first alloy; an intermediate layer secured to the self-braze layer; and a matrix bonded to the intermediate layer and at least partially embedding an abrasive.
A mixed domain test and measurement device having a trigger detector for outputting a trigger signal to trigger a signal acquisition, the trigger detector comprising: a first input coupled to a first plurality of selectable trigger circuits (106; 108; 110; 112), each trigger circuit of the first plurality of selectable trigger circuits being associated with a different signal domain and operable to output a first event signal indicative of an event occurring in data input to the first input; a second input coupled to a second plurality of selectable trigger circuits (156; 158; 160; 162), each trigger circuit of the second plurality of selectable trigger circuits being associated with a different signal domain and operable to output a second event signal indicative of an event occurring in data input to the second input; and means adapted for processing the first and second event signals output by the first and second plurality of trigger circuits to generate the trigger signal for the test and measurement device. a first input coupled to a first plurality of selectable trigger circuits (106; 108; 110; 112), each trigger circuit of the first plurality of selectable trigger circuits being associated with a different signal domain and operable to output a first event signal indicative of an event occurring in data input to the first input; a second input coupled to a second plurality of selectable trigger circuits (156; 158; 160; 162), each trigger circuit of the second plurality of selectable trigger circuits being associated with a different signal domain and operable to output a second event signal indicative of an event occurring in data input to the second input; and means adapted for processing the first and second event signals output by the first and second plurality of trigger circuits to generate the trigger signal for the test and measurement device.
A product allowing by injection the formation of a solid implant in the body of a subject, said product comprising a pharmaceutically acceptable base composition which contains at least one solvent and at least one first polysaccharide soluble in said solvent, said base composition is capable of forming a precipitate upon contact with an aqueous solution, which is possibly saline; characterised in that it further comprises a given amount of at least one active substance, which is pharmaceutically acceptable in powder form, selected from: - ionic bactericidal/antiseptic/antifungal agents soluble in said solvent such as eosin and methylene blue and potassium iodide; - antibiotics, growth factors, hydroxyapatite, hormones, antitumour agents, antimitotic agents, topoisomerase inhibitors, anticancer agents and mixtures of two or more of said active substances; and in that said amount of active substance is mixed with said base composition or packaged separately from said base composition, in that the mixture formed by said base composition and said amount of active substance has a viscosity which allows the injection of said mixture and in that said mixture forms a precipitate upon contact with an aqueous solution, which is possibly saline, allowing to form said implant in the body of the subject into which it is injected, and to diffuse said active substance into a medium surrounding the implant; and in that said first polysaccharide is ethylcellulose and said solvent is selected from ethanol and water-ethanol mixtures including at least 50% by volume of ethanol and in particular at least 90% by volume of ethanol. - ionic bactericidal/antiseptic/antifungal agents soluble in said solvent such as eosin and methylene blue and potassium iodide; - antibiotics, growth factors, hydroxyapatite, hormones, antitumour agents, antimitotic agents, topoisomerase inhibitors, anticancer agents and mixtures of two or more of said active substances; and in that said amount of active substance is mixed with said base composition or packaged separately from said base composition, in that the mixture formed by said base composition and said amount of active substance has a viscosity which allows the injection of said mixture and in that said mixture forms a precipitate upon contact with an aqueous solution, which is possibly saline, allowing to form said implant in the body of the subject into which it is injected, and to diffuse said active substance into a medium surrounding the implant; and in that said first polysaccharide is ethylcellulose and said solvent is selected from ethanol and water-ethanol mixtures including at least 50% by volume of ethanol and in particular at least 90% by volume of ethanol.
Object detection system for detecting objects, comprising: - a detection apparatus with - a mounting unit for mounting the data acquisition unit at a mounting object; - a swing motor, wherein the swing motor is connected to the mounting unit; - a swing arm, which is coupled at one end with the swing motor such, that the swing arm is pivotable about a swing axis by means of the swing motor; - a controlling unit for controlling the swing motor; and - a data acquisition unit for acquiring object information, wherein the data acquisition unit is attached to the swing arm spaced from the swing axis and the data acquisition unit is formed as 2D-laser-scanner; and - the 2D-laser-scanner is connected to the swing arm such, that a 2D-acquisition area of the 2D-laser-scanner is substantially oriented orthogonal to the longitudinal axis of the swing arm and parallel to the swing axis; and - a computation unit for computing a 3D data set from the data of the data acquisition unit and data regarding to the movement of the swing motor. - a detection apparatus with - a mounting unit for mounting the data acquisition unit at a mounting object; - a swing motor, wherein the swing motor is connected to the mounting unit; - a swing arm, which is coupled at one end with the swing motor such, that the swing arm is pivotable about a swing axis by means of the swing motor; - a controlling unit for controlling the swing motor; and - a data acquisition unit for acquiring object information, wherein the data acquisition unit is attached to the swing arm spaced from the swing axis and the data acquisition unit is formed as 2D-laser-scanner; and - the 2D-laser-scanner is connected to the swing arm such, that a 2D-acquisition area of the 2D-laser-scanner is substantially oriented orthogonal to the longitudinal axis of the swing arm and parallel to the swing axis; and - a computation unit for computing a 3D data set from the data of the data acquisition unit and data regarding to the movement of the swing motor. - a mounting unit for mounting the data acquisition unit at a mounting object; - a swing motor, wherein the swing motor is connected to the mounting unit; - a swing arm, which is coupled at one end with the swing motor such, that the swing arm is pivotable about a swing axis by means of the swing motor; - a controlling unit for controlling the swing motor; and - a data acquisition unit for acquiring object information, wherein the data acquisition unit is attached to the swing arm spaced from the swing axis and the data acquisition unit is formed as 2D-laser-scanner; and - the 2D-laser-scanner is connected to the swing arm such, that a 2D-acquisition area of the 2D-laser-scanner is substantially oriented orthogonal to the longitudinal axis of the swing arm and parallel to the swing axis; and - a computation unit for computing a 3D data set from the data of the data acquisition unit and data regarding to the movement of the swing motor.
A variable nozzle device for a turbocharger comprising: a wall member; a unison ring adjacent one face of the wall member; a plurality of vanes rotatable about a pivot axle and located adjacent an opposite face of the wall member, each vane comprising a tab member comprising a shaft portion and a tab portion for holding said vane on said wall member, the pivot axle and tab member both projecting from the same side of each respective vane body and being spaced apart by a predetermined distance along the vane body; and an insert formed as a separate element and arranged radially inside of the wall member, the insert defining holes that respectively receive the pivot axles of the vanes such that the vanes are pivotably supported about the pivot axles, wherein the wall member comprises guide slots for guiding the shaft portions of the vanes, the shaft portions sliding within the guide slots when the unison ring is rotated to pivot the vanes. a wall member; a unison ring adjacent one face of the wall member; a plurality of vanes rotatable about a pivot axle and located adjacent an opposite face of the wall member, each vane comprising a tab member comprising a shaft portion and a tab portion for holding said vane on said wall member, the pivot axle and tab member both projecting from the same side of each respective vane body and being spaced apart by a predetermined distance along the vane body; and an insert formed as a separate element and arranged radially inside of the wall member, the insert defining holes that respectively receive the pivot axles of the vanes such that the vanes are pivotably supported about the pivot axles,
A method of making an extracellular vesicle comprising a biologically active molecule linked to an extracellular vesicle via a scaffold protein, the method comprising culturing a cell comprising a nucleic acid sequence encoding the scaffold protein and the biologically active molecule, wherein the scaffold protein comprises an N-terminus domain and an effector domain; wherein the ND is associated with the luminal surface of the EV and the ED is associated with the luminal surface of the EV; wherein the ND of the scaffold protein comprises the amino acid sequence of GGKLSK (SEQ ID NO: 203), but does not comprise a methionine (Met) at the N-terminus. wherein the ND is associated with the luminal surface of the EV and the ED is associated with the luminal surface of the EV; wherein the ND of the scaffold protein comprises the amino acid sequence of GGKLSK (SEQ ID NO: 203), but does not comprise a methionine (Met) at the N-terminus.
A polyvalent, combined, immunising and/or therapeutic preparation against salmonellosis comprising inactivated Salmonella sp. strain with antibodies bound thereto, characterized in that said antibodies are obtained separately by immunization with antigens derived from Salmonella strain having lipopolysaccharide containing O-specific polysaccharides which are different than O-specific polysaccharides of lipopolysaccharide of said inactivated Salmonella sp. strain and in that the preparation contains said inactivated Salmonella sp. strain and said antibodies, bound to the said inactivated Salmonella sp. strain, wherein the antibodies are present in an amount of 25-100 mg per bacterial mass of Salmonella in concentration of 2-5x10 13 MPN (most probable number), wherein the combination of inactivated Salmonella sp. strain with antibodies bound thereto is selected from inactivated bacteria of O:4 group bound to anti-O:9 immunoglobulins produced by immunising a host using Salmonella from O:9 group, and/or inactivated bacteria of O:9 group bound to anti-O:4 immunoglobulins produced by immunising a host using Salmonella from O:4 group, and/or inactivated bacteria of O:6.7 group bound to anti-O:6.8 immunoglobulins produced by immunising a host using Salmonella from O:6.8 group, and/or inactivated bacteria of O:6,8 group bound to anti-O:6,7 immunoglobulins produced by immunising a host using Salmonella from 0:6,7 group, such as inactivated bacteria of S. Enteritidis O:9 bound to immunoglobulins produced by immunising a host using S. Paratyphi B O:4, and/or inactivated bacteria of S. Typhimurium O:4 bound to immunoglobulins produced by immunising a host using S. Kapemba O:9, and/or inactivated bacteria of S. Hadar O:6,8 bound to immunoglobulins produced by immunising a host using S. Choleraesuis O:6,7, and/or inactivated bacteria of S. Virchow 0:6,7 bound to immunoglobulins produced by immunising a host using S. Newport O:6,8, and/or inactivated bacteria of S. Infantis 0:6,7 bound to immunoglobulins produced by immunising a host using S. Newport O:6,8.
Non-human mammalian animal having (a) an increased number of leukocytes and/or neutrophils in the blood, plasma and/or serum, and (b) an inactivated gene encoding DNase 1 and DNase 1-like 3 enzyme wherein said non-human mammalian animal expresses granulocyte-colony stimulating factor (G-CSF) from a liver-specific expression plasmid, wherein said non-human animal is a mouse, wherein said non-human mammalian animal has a defect in the clearance of NETs, and wherein overexpression of the gene encoding G-CSF results in the formation of neutrophil extracellular traps (NETs). (a) an increased number of leukocytes and/or neutrophils in the blood, plasma and/or serum, and (b) an inactivated gene encoding DNase 1 and DNase 1-like 3 enzyme
A wearable electronic device comprising: a housing comprising a metal structure (101, 1350); a display positioned within the housing; a printed circuit board, PCB, (160, 1360) positioned within the housing and including a ground region and a non-conductive region (1361a, 1361b); a control circuit disposed on the PCB (160, 1360), the control circuit configured to feed a first point of the metal structure (101, 1350); and at least one first conductive connection member (1310, 1320) comprising a conductive material, the at least one first conductive connection member (1310, 1320) electrically connected with a second point (15a-1, 15a-2, 15a-3) of the metal structure (101, 1350), and characterized in that the at least one first conductive connection member (1310, 1320) is capacitively coupled to the ground region of the PCB through the non-conductive region (1361a, 1361b) of the PCB (160, 1360). a housing comprising a metal structure (101, 1350); a display positioned within the housing; a printed circuit board, PCB, (160, 1360) positioned within the housing and including a ground region and a non-conductive region (1361a, 1361b); a control circuit disposed on the PCB (160, 1360), the control circuit configured to feed a first point of the metal structure (101, 1350); and at least one first conductive connection member (1310, 1320) comprising a conductive material, the at least one first conductive connection member (1310, 1320) electrically connected with a second point (15a-1, 15a-2, 15a-3) of the metal structure (101, 1350), and characterized in that the at least one first conductive connection member (1310, 1320) is capacitively coupled to the ground region of the PCB through the non-conductive region (1361a, 1361b) of the PCB (160, 1360).