A method for manufacturing a high-strength thick steel plate having a thickness of 50 mm or more for structural use with excellent brittle crack arrestability, the method comprising: heating a slab at a temperature of 1000°C to 1200°C, wherein the slab has a chemical composition consisting of, by mass%, C: 0.03% or more and 0.20% or less, Si: 0.03% or more and 0.5% or less, Mn: 0.5% or more and 2.5% or less, Al: 0.005% or more and 0.08% or less, P: 0.03% or less, S: 0.01% or less, N: 0.0050% or less, Ti: 0.005% or more and 0.03% or less, and optionally one or more of Nb: 0.005% or more and 0.05% or less, Cu: 0.01% or more and 0.5% or less, Ni: 0.01% or more and 1.0% or less, Cr: 0.01% or more and 0.5% or less, Mo: 0.01% or more and 0.5% or less, V: 0.001% or more and 0.10% or less, B: 0.0030% or less, Ca: 0.0050% or less, and REM: 0.010% or less, and the balance being Fe and inevitable impurities; performing rolling so that the total cumulative rolling reduction in an austenite recrystallization temperature range and in an austenite non-recrystallization temperature range is 65% or more, in which, firstly, while the central portion in the thickness direction has a temperature in the austenite recrystallization temperature range, the cumulative rolling reduction is controlled to be 20% or more, and subsequently, while the central portion in the thickness direction has a temperature in the austenite non-recrystallization temperature range, the cumulative rolling reduction is controlled to be 40% or more, wherein the difference in rolling temperature between the first pass and the last pass is controlled to be 40 °C or less, wherein the rolling temperature means the temperature of the central portion in the thickness direction of a steel material immediately before the steel material is rolled; and performing cooling on the rolled steel plate down to a temperature of 450°C or lower at a cooling rate of 4°C/s or more, wherein said temperature and cooling rate are determined by using the temperature of the central portion in the thickness direction of the steel plate. heating a slab at a temperature of 1000°C to 1200°C, wherein the slab has a chemical composition consisting of, by mass%, C: 0.03% or more and 0.20% or less, Si: 0.03% or more and 0.5% or less, Mn: 0.5% or more and 2.5% or less, Al: 0.005% or more and 0.08% or less, P: 0.03% or less, S: 0.01% or less, N: 0.0050% or less, Ti: 0.005% or more and 0.03% or less, and optionally one or more of Nb: 0.005% or more and 0.05% or less, Cu: 0.01% or more and 0.5% or less, Ni: 0.01% or more and 1.0% or less, Cr: 0.01% or more and 0.5% or less, Mo: 0.01% or more and 0.5% or less, V: 0.001% or more and 0.10% or less, B: 0.0030% or less, Ca: 0.0050% or less, and REM: 0.010% or less, and the balance being Fe and inevitable impurities; performing rolling so that the total cumulative rolling reduction in an austenite recrystallization temperature range and in an austenite non-recrystallization temperature range is 65% or more, in which, firstly, while the central portion in the thickness direction has a temperature in the austenite recrystallization temperature range, the cumulative rolling reduction is controlled to be 20% or more, and subsequently, while the central portion in the thickness direction has a temperature in the austenite non-recrystallization temperature range, the cumulative rolling reduction is controlled to be 40% or more, wherein the difference in rolling temperature between the first pass and the last pass is controlled to be 40 °C or less, wherein the rolling temperature means the temperature of the central portion in the thickness direction of a steel material immediately before the steel material is rolled; and firstly, while the central portion in the thickness direction has a temperature in the austenite recrystallization temperature range, the cumulative rolling reduction is controlled to be 20% or more, and subsequently, while the central portion in the thickness direction has a temperature in the austenite non-recrystallization temperature range, the cumulative rolling reduction is controlled to be 40% or more, wherein the difference in rolling temperature between the first pass and the last pass is controlled to be 40 °C or less, wherein the rolling temperature means the temperature of the central portion in the thickness direction of a steel material immediately before the steel material is rolled; and performing cooling on the rolled steel plate down to a temperature of 450°C or lower at a cooling rate of 4°C/s or more, wherein said temperature and cooling rate are determined by using the temperature of the central portion in the thickness direction of the steel plate.