mhurhangee/ep-ind-claims huggingface dataset:
A genetically engineered microorganism, said microorganism having a reverse beta oxidation (BOX-R) cycle that grows a primer by adding a 2-carbon donor thereto in each cycle, said BOX-R cycle comprising: a) an overexpressed thiolase that catalyzes the non-decarboxylative condensation of an acyl-CoA primer with a 2-carbon donor acetyl-CoA to produce a β-ketoacyl-CoA; b) an overexpressed 3-oxoacyl-[acyl-carrier-protein] reductase or overexpressed 3-hydroxyacyl-CoA dehydrogenase that catalyzes the reduction of a β-ketoacyl-CoA to a β-hydroxyayl-CoA; c) an overexpressed 3-hydroxyacyl-[acyl-carrier-protein] dehydratase or an overexpressed enoyl-CoA hydratase or 3-hydroxyacyl-CoA dehydratase that catalyzes the dehydration of a -β-hydroxyacyl-CoA to a transenoyl-CoA; d) an overexpressed enoyl-[acyl-carrier-protein] reductase or acyl-CoA dehydrogenase or trans-enoyl-CoA reductase that catalyzes the reduction of a transenoyl-CoA to an acyl-CoA that is two carbons longer than said acyl coA primer; i) wherein at least one of the enzymes from steps b-d is a fatty acid synthesis enzyme; e) an overexpressed termination pathway that catalyzes the exit of an intermediate from said BOX-R cycle. a) an overexpressed thiolase that catalyzes the non-decarboxylative condensation of an acyl-CoA primer with a 2-carbon donor acetyl-CoA to produce a β-ketoacyl-CoA; b) an overexpressed 3-oxoacyl-[acyl-carrier-protein] reductase or overexpressed 3-hydroxyacyl-CoA dehydrogenase that catalyzes the reduction of a β-ketoacyl-CoA to a β-hydroxyayl-CoA; c) an overexpressed 3-hydroxyacyl-[acyl-carrier-protein] dehydratase or an overexpressed enoyl-CoA hydratase or 3-hydroxyacyl-CoA dehydratase that catalyzes the dehydration of a -β-hydroxyacyl-CoA to a transenoyl-CoA; d) an overexpressed enoyl-[acyl-carrier-protein] reductase or acyl-CoA dehydrogenase or trans-enoyl-CoA reductase that catalyzes the reduction of a transenoyl-CoA to an acyl-CoA that is two carbons longer than said acyl coA primer; i) wherein at least one of the enzymes from steps b-d is a fatty acid synthesis enzyme; i) wherein at least one of the enzymes from steps b-d is a fatty acid synthesis enzyme; e) an overexpressed termination pathway that catalyzes the exit of an intermediate from said BOX-R cycle.
Non-directional radio frequency power divider with the following features: - with an outer conductor or an outer conductor housing that forms an outer conductor, - with a first inner conductor, - the first inner conductor runs inside the outer conductor or in the outer conductor housing, - with a second inner conductor, - the second inner conductor runs inside the space, which is formed between the first inner conductor and the outer conductor or the outer conductor housing, - the second inner conductor is electrically connected to or provided with a branch conductor running away from it, - the branch conductor is positioned in the centre between the two ends of the second inner conductor, - the second inner conductor extends in parallel with the first inner conductor, characterised by the following additional features: - the second inner conductor is relatively adjustable in terms of its distance from the first inner conductor and in terms of its distance from the outer conductor or outer conductor housing so as to effect a variable power distribution - with an outer conductor or an outer conductor housing that forms an outer conductor, - with a first inner conductor, - the first inner conductor runs inside the outer conductor or in the outer conductor housing, - with a second inner conductor, - the second inner conductor runs inside the space, which is formed between the first inner conductor and the outer conductor or the outer conductor housing, - the second inner conductor is electrically connected to or provided with a branch conductor running away from it, - the branch conductor is positioned in the centre between the two ends of the second inner conductor, - the second inner conductor extends in parallel with the first inner conductor, characterised by the following additional features: - the second inner conductor is relatively adjustable in terms of its distance from the first inner conductor and in terms of its distance from the outer conductor or outer conductor housing so as to effect a variable power distribution
A differential pH probe comprising - a container having an outer surface and an inner volume; - a first active chamber at a first end of said container and filled with an electrolyte solution; - a first electrode configured to detect a voltage in said first active chamber; - the outer surface of said container including a first pH-sensitive area in correspondence of said first active chamber, whereby said first pH-sensitive area is configured to be exposed to a sample; - a second electrode configured to detect a reference voltage; - circuitry coupled to said first and second electrodes (111, 112) and configured to process said voltages to determine the pH of a sample; - a conductive enclosure inside which said container is housed, said first end of said container protruding from an end of said enclosure; - a first seal and a second seal coupling the outer surface of said container and the inner surface of said conductive enclosure to form a compartment that holds a buffer solution, wherein - the outer surface of said container comprises a second pH-sensitive area separated from said first pH-sensitive area by a non-active area; - a third seal within said inner volume, delimiting said first active chamber; - a fourth seal within said inner volume, delimiting a second active chamber that is filled with an electrolyte and that is placed in correspondence of said second pH-sensitive area of said outer surface; - said second electrode being exposed inside said second active chamber. - a container having an outer surface and an inner volume; - a first active chamber at a first end of said container and filled with an electrolyte solution; - a first electrode configured to detect a voltage in said first active chamber; - the outer surface of said container including a first pH-sensitive area in correspondence of said first active chamber, whereby said first pH-sensitive area is configured to be exposed to a sample; - a second electrode configured to detect a reference voltage; - circuitry coupled to said first and second electrodes (111, 112) and configured to process said voltages to determine the pH of a sample; - a conductive enclosure inside which said container is housed, said first end of said container protruding from an end of said enclosure; - a first seal and a second seal coupling the outer surface of said container and the inner surface of said conductive enclosure to form a compartment that holds a buffer solution, - the outer surface of said container comprises a second pH-sensitive area separated from said first pH-sensitive area by a non-active area; - a third seal within said inner volume, delimiting said first active chamber; - a fourth seal within said inner volume, delimiting a second active chamber that is filled with an electrolyte and that is placed in correspondence of said second pH-sensitive area of said outer surface; - said second electrode being exposed inside said second active chamber.
A method for providing access to an Internet resource of a first domain comprising: at a front end of a DNS application server authoritative on a second domain: receiving status data comprising measures of access quality reflecting access quality experienced by a web client accessing two or more copies (42a, 42b) of the Internet resource maintained within respective infrastructures (44a, 44b); receiving a redirected DNS query to resolve a hostname on the second domain, the hostname comprising a name of an executable selector code on the DNS application server and an indicator of a provider of the first domain; invoking (310, 36) the executable selector code by the name and conveying the status data to the selector code to use in selecting among the respective infrastructures (44a, 44b); receiving (312, 38) from the executable selector code a hostname alias resolving to a selected one of the respective infrastructures (44a, 44b); and communicating a DNS response to the DNS query to redirect the DNS query to a nameserver authoritative for the selected infrastructure (44a, 44b). receiving status data comprising measures of access quality reflecting access quality experienced by a web client accessing two or more copies (42a, 42b) of the Internet resource maintained within respective infrastructures (44a, 44b); receiving a redirected DNS query to resolve a hostname on the second domain, the hostname comprising a name of an executable selector code on the DNS application server and an indicator of a provider of the first domain; invoking (310, 36) the executable selector code by the name and conveying the status data to the selector code to use in selecting among the respective infrastructures (44a, 44b); receiving (312, 38) from the executable selector code a hostname alias resolving to a selected one of the respective infrastructures (44a, 44b); and communicating a DNS response to the DNS query to redirect the DNS query to a nameserver authoritative for the selected infrastructure (44a, 44b).
A spring driven drug delivery device for delivering set doses of a liquid drug comprising: a housing (3;1003) fixating a cartridge (105;1105) containing the liquid drug to be injected, a rotatable dose setting button at a proximal end for dialing the size of the dose, a scale drum (60;160) rotatably (61;161) engaged with the housing (3;1003); a needle shield (20;120) for covering an injection needle during use, which needle shield (20;120) under influence of spring means is axially slidable in relation to the housing, and wherein the scale drum (60;160) is provided with engaging means which engages and locks the needle shield (20; 120) from axial movement when in the zero position, characterised in that - the scale drum (60, 160) is threadely engaged with the housing (3; 1003) to perform a helical movement away from a zero position during setting of a dose; - a window is provided in the housing (3; 1003) through which a user can visually inspect the size of the dose being set by rotating the dose setting button and in which window the cipher "0" or similar indicia appears whenever the scale drum is in its zero position; and wherein when a dose is dialed the scale drum moves away from its zero position whereby the engagement means releases and set the needle shield free to move axially under influence of the spring whereby the needle shield is slidable into a position in which the needle shield covers the injection needle. a housing (3;1003) fixating a cartridge (105;1105) containing the liquid drug to be injected, a rotatable dose setting button at a proximal end for dialing the size of the dose, a scale drum (60;160) rotatably (61;161) engaged with the housing (3;1003); a needle shield (20;120) for covering an injection needle during use, which needle shield (20;120) under influence of spring means is axially slidable in relation to the housing, and wherein the scale drum (60;160) is provided with engaging means which engages and locks the needle shield (20; 120) from axial movement when in the zero position, - the scale drum (60, 160) is threadely engaged with the housing (3; 1003) to perform a helical movement away from a zero position during setting of a dose; - a window is provided in the housing (3; 1003) through which a user can visually inspect the size of the dose being set by rotating the dose setting button and in which window the cipher "0" or similar indicia appears whenever the scale drum is in its zero position; and wherein when a dose is dialed the scale drum moves away from its zero position whereby the engagement means releases and set the needle shield free to move axially under influence of the spring whereby the needle shield is slidable into a position in which the needle shield covers the injection needle.
A method, performed in a wireless device, for determining a decoding margin in communication with a radio network node, wherein the method comprises: - receiving a transport block from a radio network node; characterized by - creating one or more punctured versions of the transport block, wherein an encoding redundancy of the punctured versions of the transport block is reduced compared to that of the transport block; - decoding at least one of the one or more punctured versions of the transport block; - determining a decoding margin associated with the original transport block, based on the decoding of the one or more punctured versions of the transport block, wherein the step of determining the decoding margin comprises: determining a number of successfully decoded punctured versions of the transport block, or determining a highest code rate after puncturing for which the decoding is successful, wherein the highest code rate is associated with a lowest coding redundancy, or determining a ratio or difference between a code rate of the decoded received transport block and a code rate of a successfully decoded punctured version of the transport block; and - transmitting information defining the decoding margin to a radio network node. - receiving a transport block from a radio network node; characterized by - creating one or more punctured versions of the transport block, wherein an encoding redundancy of the punctured versions of the transport block is reduced compared to that of the transport block; - decoding at least one of the one or more punctured versions of the transport block; - determining a decoding margin associated with the original transport block, based on the decoding of the one or more punctured versions of the transport block, wherein the step of determining the decoding margin comprises: determining a number of successfully decoded punctured versions of the transport block, or determining a highest code rate after puncturing for which the decoding is successful, wherein the highest code rate is associated with a lowest coding redundancy, or determining a ratio or difference between a code rate of the decoded received transport block and a code rate of a successfully decoded punctured version of the transport block; and - transmitting information defining the decoding margin to a radio network node.
A in vitro method for integrating a sequence encoding at least one heterologous protein into a chromosome of a cell such that expression of the at least one heterologous protein is regulated by an endogenous regulatory system, the method comprising: a) introducing into the cell (i) at least one targeting endonuclease or nucleic acid encoding a targeting endonuclease, the targeting endonuclease being able to bind a target sequence and cut a cleavage site in a targeted chromosomal sequence that codes an endogenous protein chosen from the group consisting of an actin, a tubulin and a lamin; and (ii) at least one donor polynucleotide comprising the sequence encoding the at least one heterologous protein that is linked to a sequence encoding a 2A peptide to form a heterologous protein coding sequence, the heterologous protein coding sequence being flanked by an upstream sequence and a downstream sequence that have substantial sequence identity with either side of the cleavage site; and b) maintaining the cell under conditions such that a double-stranded break introduced into the targeted chromosomal sequence by the targeting endonuclease is repaired by a homology-directed repair process such that the heterologous protein coding sequence in the donor polynucleotide is integrated in-frame into the targeted chromosomal sequence, whereby expression of the at least one heterologous protein is regulated by the endogenous regulatory system that regulates expression of the endogenous protein. a) introducing into the cell (i) at least one targeting endonuclease or nucleic acid encoding a targeting endonuclease, the targeting endonuclease being able to bind a target sequence and cut a cleavage site in a targeted chromosomal sequence that codes an endogenous protein chosen from the group consisting of an actin, a tubulin and a lamin; and (ii) at least one donor polynucleotide comprising the sequence encoding the at least one heterologous protein that is linked to a sequence encoding a 2A peptide to form a heterologous protein coding sequence, the heterologous protein coding sequence being flanked by an upstream sequence and a downstream sequence that have substantial sequence identity with either side of the cleavage site; and b) maintaining the cell under conditions such that a double-stranded break introduced into the targeted chromosomal sequence by the targeting endonuclease is repaired by a homology-directed repair process such that the heterologous protein coding sequence in the donor polynucleotide is integrated in-frame into the targeted chromosomal sequence, whereby expression of the at least one heterologous protein is regulated by the endogenous regulatory system that regulates expression of the endogenous protein.
A device for dispensing a fluid product characterised in that it comprises: - a fluid product dispenser having a tank containing a fluid product, a dispensing head having a dispensing port, said dispensing head being axially movable with respect to said tank, and a dispensing member, such as a pump or a valve, mounted on said tank, said dispensing member being actuated when said tank is moved axially upwards with respect to said dispensing head; - an inner body comprising a hollow cylinder receiving said dispenser and an axial extension extending axially downwards from said hollow cylinder, - a control module (80, 81, 82, 83, 90) attached to said inner body, said control module comprising an electronic board, a motor and a motor wheel caused to rotate by said motor, - an outer body receiving said inner body and said control module, - a thrust member in contact with said tank and mounted so as to be axially movable on said inner body between a rest position and an actuation position, - a control member attached to said thrust member and axially moving together therewith, - a locking ring mounted on said axial extension of said inner body so as to be capable of rotating between locking and releasing positions, said locking ring being moved between the latter locking and releasing positions by said control module, said locking ring co-operating in the locking position with said thrust member so as to prevent axial movement of the latter and co-operating in the releasing position with said thrust member so as to enable axial movement of the latter towards the actuation position thereof. - a fluid product dispenser having a tank containing a fluid product, a dispensing head having a dispensing port, said dispensing head being axially movable with respect to said tank, and a dispensing member, such as a pump or a valve, mounted on said tank, said dispensing member being actuated when said tank is moved axially upwards with respect to said dispensing head; - an inner body comprising a hollow cylinder receiving said dispenser and an axial extension extending axially downwards from said hollow cylinder, - a control module (80, 81, 82, 83, 90) attached to said inner body, said control module comprising an electronic board, a motor and a motor wheel caused to rotate by said motor, - an outer body receiving said inner body and said control module, - a thrust member in contact with said tank and mounted so as to be axially movable on said inner body between a rest position and an actuation position, - a control member attached to said thrust member and axially moving together therewith, - a locking ring mounted on said axial extension of said inner body so as to be capable of rotating between locking and releasing positions, said locking ring being moved between the latter locking and releasing positions by said control module, said locking ring co-operating in the locking position with said thrust member so as to prevent axial movement of the latter and co-operating in the releasing position with said thrust member so as to enable axial movement of the latter towards the actuation position thereof.
A method of generating a command of a fuel flow rate to be injected into a combustion chamber of a turbine engine for propelling an aircraft, the method being for use during a stage of starting the turbine engine, and comprising: • an open-loop generating step of generating a fuel flow rate command (WF_OL) from at least one pre-established relationship; and • a closed-loop monitoring step (E20-E30) of monitoring at least one operating parameter of the turbine engine selected from: • a rate of acceleration (dN2/dt) of a compressor of the turbine engine; and • a temperature at the outlet from a turbine of the turbine engine; this monitoring step comprising maintaining the operating parameter in a determined range of values by using at least one corrector network (R1, R2, R3) associated with the parameter and suitable for delivering a signal for correcting the open-loop generated fuel flow rate command so as to maintain the operating parameter in the determined range of values. • an open-loop generating step of generating a fuel flow rate command (WF_OL) from at least one pre-established relationship; and • a closed-loop monitoring step (E20-E30) of monitoring at least one operating parameter of the turbine engine selected from: • a rate of acceleration (dN2/dt) of a compressor of the turbine engine; and • a temperature at the outlet from a turbine of the turbine engine; • a rate of acceleration (dN2/dt) of a compressor of the turbine engine; and • a temperature at the outlet from a turbine of the turbine engine;
Mounting of a system for determining angular position on a rotating member, said system comprising: - an encoder which is rigidly connected in rotation to said rotating member, said encoder comprising a primary magnetic track and a secondary magnetic track which are each suitable for emitting a periodic signal representative of the movement of said encoder; and - a sensor having two patterns of sensitive elements which are suitable for detecting the signals supplied by the tracks (2, 3) of the encoder, each pattern being arranged along a reading surface which extends to a reading distance of a track (2, 3) to form a representative signal of the angular position of said track, said sensor further comprising a device for processing the signals from the patterns to determine the absolute angular position of the rotating member; each sensitive element of the patterns having at least one sensitive layer based on a magnetoresistive material wherein the resistance varies as a function of the magnetic signal of the track (2, 3) to be detected, each pattern being arranged such that said sensitive layer extends in a general plane which is perpendicular to the reading surface of said track, said mounting being characterised in that the sensor comprises an electronic board having two faces (8a, 8b) whereon respectively a pattern is arranged. - an encoder which is rigidly connected in rotation to said rotating member, said encoder comprising a primary magnetic track and a secondary magnetic track which are each suitable for emitting a periodic signal representative of the movement of said encoder; and - a sensor having two patterns of sensitive elements which are suitable for detecting the signals supplied by the tracks (2, 3) of the encoder, each pattern being arranged along a reading surface which extends to a reading distance of a track (2, 3) to form a representative signal of the angular position of said track, said sensor further comprising a device for processing the signals from the patterns to determine the absolute angular position of the rotating member;