A compound having the following structure: or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: X is C or C(R 3) 2; Y is a bond, Y 1, O, NH, NR 2, C O, OC, C NR 2 ', NR 2 'C, Y 1 -O, Y 1 -NH, Y 1 -NR 2, Y 1 -C, Y 1 -C O, Y 1 -OC, Y 1 -C NR 2 ', or Y 1 -NR 2 'C; Y 1 is C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene; m is 0, 1, 2, or 3; n is 0, 1, or 2; each R 1 is independently halogen, nitro, NH 2, OH, C OH, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 2 is C 1 -C 6 alkyl, C -C 1 -C 6 alkyl, or C -C 3 -C 6 cycloalkyl; R 2 ' is H or C 1 -C 6 alkyl; R 3 is H or C 1 -C 3 alkyl; each R 3 ' is independently C 1 -C 3 alkyl; each R 4 is independently H or C 1 -C 3 alkyl; or two R 4, together with the carbon atom to which they are attached, form a C, a C 3 -C 6 carbocycle, or a 4-, 5-, or 6-membered heterocycle comprising 1 or 2 heteroatoms selected from N and O; R 5 is H, deuterium, C 1 -C 3 alkyl, F, or Cl; each W is independently absent, CH 2, O, S, NH or NR 5; Z is absent, CH 2, O, NH or NR 5; Q is absent or -CH 2 C NH-; p1 is selected from 0, 1, 2, 3, 4, 5, and 6; p2 is selected from 0, 1, 2, 3, 4, 5, and 6; p3 is selected from 1, 2, 3, 4, and 5; Targeting Ligand is selected from: and nn3 is 0, 1, 2, or 3; nn6 is 0, 1, 2, or 3; nn7 is 0, 1, 2, or 3; nn8 is 0, 1, 2, or 3; nn9 is 0, 1, 2, or 3; nn12 is 0, 1, 2, or 3; Rb 1, Rb 2, and Rb 5 are each independently H or C 1 -C 3 alkyl; Rb 5 is C 3 -C 6 cycloalkyl; each Rb 4 is independently H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; each Rb 6 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rb 7 is C NRb 8 L, OL, NRbsL, or L; Rb 8 is H or C 1 -C 3 alkyl; each Rd 1 is independently H or C 1 -C 3 alkyl; each Rd 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rd 3 is C NRd 4 L, OL, NRd 4 L, or L; Rd 4 is H or C 1 -C 3 alkyl; each Re 1 is independently H or C 1 -C 3 alkyl; each Re 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Re 3 is NH-(CH 2) 1-3 -C NRe 4 L, C NRe 4 L, OL, NRe 4 L, or L; Re 4 is H or C 1 -C 3 alkyl; Rf 1 is C NRf 2 L, OL, NRf 2 L, or L; Rf 2 is independently H or C 1 -C 3 alkyl; each Rh 1 is independently H or C 1 -C 3 alkyl; each Rh 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rh 3 is C L or C -(CH 2) 1-3 -C NRh 6 L; Rh 6 is H or C 1 -C 3 alkyl; Rh 4 is H or C 1 -C 3 alkyl; Rh 5 is C 1 -C 6 alkyl; T 6 is CRb 4 or N; and L is the attachment point to Z. X is C or C(R 3) 2; Y is a bond, Y 1, O, NH, NR 2, C O, OC, C NR 2 ', NR 2 'C, Y 1 -O, Y 1 -NH, Y 1 -NR 2, Y 1 -C, Y 1 -C O, Y 1 -OC, Y 1 -C NR 2 ', or Y 1 -NR 2 'C; Y 1 is C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene; m is 0, 1, 2, or 3; n is 0, 1, or 2; each R 1 is independently halogen, nitro, NH 2, OH, C OH, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; R 2 is C 1 -C 6 alkyl, C -C 1 -C 6 alkyl, or C -C 3 -C 6 cycloalkyl; R 2 ' is H or C 1 -C 6 alkyl; R 3 is H or C 1 -C 3 alkyl; each R 3 ' is independently C 1 -C 3 alkyl; each R 4 is independently H or C 1 -C 3 alkyl; or two R 4, together with the carbon atom to which they are attached, form a C, a C 3 -C 6 carbocycle, or a 4-, 5-, or 6-membered heterocycle comprising 1 or 2 heteroatoms selected from N and O; R 5 is H, deuterium, C 1 -C 3 alkyl, F, or Cl; each W is independently absent, CH 2, O, S, NH or NR 5; Z is absent, CH 2, O, NH or NR 5; Q is absent or -CH 2 C NH-; p1 is selected from 0, 1, 2, 3, 4, 5, and 6; p2 is selected from 0, 1, 2, 3, 4, 5, and 6; p3 is selected from 1, 2, 3, 4, and 5; Targeting Ligand is selected from: and nn3 is 0, 1, 2, or 3; nn6 is 0, 1, 2, or 3; nn7 is 0, 1, 2, or 3; nn8 is 0, 1, 2, or 3; nn9 is 0, 1, 2, or 3; nn12 is 0, 1, 2, or 3; Rb 1, Rb 2, and Rb 5 are each independently H or C 1 -C 3 alkyl; Rb 5 is C 3 -C 6 cycloalkyl; each Rb 4 is independently H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; each Rb 6 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rb 7 is C NRb 8 L, OL, NRbsL, or L; Rb 8 is H or C 1 -C 3 alkyl; each Rd 1 is independently H or C 1 -C 3 alkyl; each Rd 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rd 3 is C NRd 4 L, OL, NRd 4 L, or L; Rd 4 is H or C 1 -C 3 alkyl; each Re 1 is independently H or C 1 -C 3 alkyl; each Re 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Re 3 is NH-(CH 2) 1-3 -C NRe 4 L, C NRe 4 L, OL, NRe 4 L, or L; Re 4 is H or C 1 -C 3 alkyl; Rf 1 is C NRf 2 L, OL, NRf 2 L, or L; Rf 2 is independently H or C 1 -C 3 alkyl; each Rh 1 is independently H or C 1 -C 3 alkyl; each Rh 2 is independently C 1 -C 3 alkyl, C 1 -C 3 alkoxy, CN, or halogen; Rh 3 is C L or C -(CH 2) 1-3 -C NRh 6 L; Rh 6 is H or C 1 -C 3 alkyl; Rh 4 is H or C 1 -C 3 alkyl; Rh 5 is C 1 -C 6 alkyl; T 6 is CRb 4 or N; and L is the attachment point to Z.