A system for treating a tissue site, comprising: a dressing (102, 302, 402, 802) adapted to be placed on the tissue site; a diagnostic module (140, 340, 440, 540, 740, 840) adapted to be positioned adjacent the dressing (102, 302, 402, 802) and comprising: a first sensor (442, 542, 642) configured to detect a pH level of fluid present at the tissue site and to generate a first output based on the detected pH level, the first sensor (442, 542, 642) comprising a first transceiver configured to transmit the first output; a first remote sensor device (444, 544, 644) comprising a second sensor, wherein the second sensor is configured to detect a secondary pH level and to generate a second output based on the detected secondary pH level, the first remote sensor device (444, 544, 644) comprising a second transceiver configured to transmit the second output generated by the second sensor; a negative-pressure source adapted to be fluidly coupled to the dressing (102, 302, 402, 802); a first fluid source adapted to be fluidly coupled to the dressing (102, 302, 402, 802) and to deliver a first fluid to the dressing (102, 302, 402, 802); and a controller configured to receive the first output and control the negative-pressure source and the fluid source based on the first output from the first sensor and to receive the second output and compare the first output to the second output. a dressing (102, 302, 402, 802) adapted to be placed on the tissue site; a diagnostic module (140, 340, 440, 540, 740, 840) adapted to be positioned adjacent the dressing (102, 302, 402, 802) and comprising: a first sensor (442, 542, 642) configured to detect a pH level of fluid present at the tissue site and to generate a first output based on the detected pH level, the first sensor (442, 542, 642) comprising a first transceiver configured to transmit the first output; a first remote sensor device (444, 544, 644) comprising a second sensor, wherein the second sensor is configured to detect a secondary pH level and to generate a second output based on the detected secondary pH level, the first remote sensor device (444, 544, 644) comprising a second transceiver configured to transmit the second output generated by the second sensor; a first sensor (442, 542, 642) configured to detect a pH level of fluid present at the tissue site and to generate a first output based on the detected pH level, the first sensor (442, 542, 642) comprising a first transceiver configured to transmit the first output; a first remote sensor device (444, 544, 644) comprising a second sensor, wherein the second sensor is configured to detect a secondary pH level and to generate a second output based on the detected secondary pH level, the first remote sensor device (444, 544, 644) comprising a second transceiver configured to transmit the second output generated by the second sensor; a negative-pressure source adapted to be fluidly coupled to the dressing (102, 302, 402, 802); a first fluid source adapted to be fluidly coupled to the dressing (102, 302, 402, 802) and to deliver a first fluid to the dressing (102, 302, 402, 802); and a controller configured to receive the first output and control the negative-pressure source and the fluid source based on the first output from the first sensor and to receive the second output and compare the first output to the second output.