A biopsy device, the biopsy device comprising: (a) a probe body; (b) a needle portion extending distally from the probe body, wherein the needle portion comprises a transverse tissue receiving aperture; (c) a hollow cutter positioned within the needle portion, wherein the cutter is translatable within the needle portion to sever a tissue sample from tissue protruding through the aperture, wherein the hollow cutter defines a cutter lumen; and (d) a tissue sample holder, wherein the tissue sample holder comprises: (i) at least two tissue sample chambers (345A; 345B; 345C; 345D, 308), wherein each of the chambers (345A; 345B; 345C; 345D, 308) extends in an axial direction, wherein the axial direction is parallel with the cutter lumen, and (ii) at least one tray removably engaged with at least one of the tissue sample chambers (345A; 345B; 345C; 345D), wherein the at least one tray is removable from the tissue sample chamber (345A; 345B; 345C; 345D) in an axial direction, wherein the at least two tissue sample chambers (345A; 345B; 345C; 345D, 308) comprise a first chamber and a second chamber (345A; 345B; 345C; 345D), wherein the first tissue sample chamber defines a first volume, wherein the second tissue sample chamber (345A; 345B; 345C; 345D) defines a second volume, wherein the tissue sample holder is rotatable to selectively index a tissue sample chamber of the first and second tissue sample chambers (345A; 345B; 345C; 345D, 308) with the cutter lumen to receive the tissue sample in the indexed tissue sample chamber (345A; 345B; 345C; 345D, 308), characterized in that: the first volume is greater than the second volume. (a) a probe body; (b) a needle portion extending distally from the probe body, wherein the needle portion comprises a transverse tissue receiving aperture; (c) a hollow cutter positioned within the needle portion, wherein the cutter is translatable within the needle portion to sever a tissue sample from tissue protruding through the aperture, wherein the hollow cutter defines a cutter lumen; and (d) a tissue sample holder, wherein the tissue sample holder comprises: (i) at least two tissue sample chambers (345A; 345B; 345C; 345D, 308), wherein each of the chambers (345A; 345B; 345C; 345D, 308) extends in an axial direction, wherein the axial direction is parallel with the cutter lumen, and (ii) at least one tray removably engaged with at least one of the tissue sample chambers (345A; 345B; 345C; 345D), wherein the at least one tray is removable from the tissue sample chamber (345A; 345B; 345C; 345D) in an axial direction, wherein the at least two tissue sample chambers (345A; 345B; 345C; 345D, 308) comprise a first chamber and a second chamber (345A; 345B; 345C; 345D), wherein the first tissue sample chamber defines a first volume, wherein the second tissue sample chamber (345A; 345B; 345C; 345D) defines a second volume, wherein the tissue sample holder is rotatable to selectively index a tissue sample chamber of the first and second tissue sample chambers (345A; 345B; 345C; 345D, 308) with the cutter lumen to receive the tissue sample in the indexed tissue sample chamber (345A; 345B; 345C; 345D, 308), characterized in that: the first volume is greater than the second volume. (i) at least two tissue sample chambers (345A; 345B; 345C; 345D, 308), wherein each of the chambers (345A; 345B; 345C; 345D, 308) extends in an axial direction, wherein the axial direction is parallel with the cutter lumen, and (ii) at least one tray removably engaged with at least one of the tissue sample chambers (345A; 345B; 345C; 345D), wherein the at least one tray is removable from the tissue sample chamber (345A; 345B; 345C; 345D) in an axial direction,