A system (100; 410) for providing irrigation into an eye of a patient during a medical procedure, the system comprising: an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including: a relatively more flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient; a relatively more rigid engagement member at the distal end, the engagement member being configured to enter into a vitreous chamber of the eye of the patient; and a plurality of pressure sensors (426,428; 502-510) connected to the infusion line and configured to measure one or more pressures associated with the infusion line during the medical procedure; characterized in that at least three of the pressure sensors (502, 504, 506) are internally disposed at different locations along the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential equal to the difference between a given pressure sensor's measurement and the measurement of a closest, more proximate sensor, wherein the pressure differential measurements may be used to indicate a presence and general location of a flow impediment along the infusion line between two of the at least three pressure sensors. an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including: a relatively more flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient; a relatively more rigid engagement member at the distal end, the engagement member being configured to enter into a vitreous chamber of the eye of the patient; and a relatively more flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient; a relatively more rigid engagement member at the distal end, the engagement member being configured to enter into a vitreous chamber of the eye of the patient; and a plurality of pressure sensors (426,428; 502-510) connected to the infusion line and configured to measure one or more pressures associated with the infusion line during the medical procedure; characterized in that at least three of the pressure sensors (502, 504, 506) are internally disposed at different locations along the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential equal to the difference between a given pressure sensor's measurement and the measurement of a closest, more proximate sensor, wherein the pressure differential measurements may be used to indicate a presence and general location of a flow impediment along the infusion line between two of the at least three pressure sensors.