An apparatus for application of surgical clips to body tissue, which comprises: a) a handle portion that includes a trigger that is compressed to apply the surgical clips; b) a body extending distally from the handle portion and defining a longitudinal axis; c) a plurality of surgical clips disposed within the body; d) a clip follower that biases the clips distally; e) a jaw assembly mounted adjacent a distal end portion of the body, the jaw assembly including first and second jaw portions movable between a spaced apart and an approximated position; f) a feed bar and a clip pusher on said feed bar, wherein said feed bar is configured to individually distally advance a surgical clip to the jaw assembly while the jaw portions are in a spaced apart position; g) an actuator at least partially disposed within the body and including a drive member that is longitudinally movable in response to actuation of the handle portion; h) a jaw closure member positioned distally of the actuator and adjacent the first and second jaw portions and driven by the drive member to move the jaw portions to the approximated position upon longitudinal movement of the actuator; and i) a lock-out mechanism including a member that is longitudinally movable with the actuator to a distal most position; characterized in that: the actuator has at least one actuator angled surface; the lock-out mechanism is affixed to the feed bar, the member having at least one member angled surface, wherein as the actuator retracts proximally the at least one actuator angled surface engages said member angled surface, wherein said engagement prevents said actuator from retracting proximal to said proximal most position thereby preventing re-actuation of the apparatus subsequent to the application of a final surgical clip. a) a handle portion that includes a trigger that is compressed to apply the surgical clips; b) a body extending distally from the handle portion and defining a longitudinal axis; c) a plurality of surgical clips disposed within the body; d) a clip follower that biases the clips distally; e) a jaw assembly mounted adjacent a distal end portion of the body, the jaw assembly including first and second jaw portions movable between a spaced apart and an approximated position; f) a feed bar and a clip pusher on said feed bar, wherein said feed bar is configured to individually distally advance a surgical clip to the jaw assembly while the jaw portions are in a spaced apart position; g) an actuator at least partially disposed within the body and including a drive member that is longitudinally movable in response to actuation of the handle portion; h) a jaw closure member positioned distally of the actuator and adjacent the first and second jaw portions and driven by the drive member to move the jaw portions to the approximated position upon longitudinal movement of the actuator; and i) a lock-out mechanism including a member that is longitudinally movable with the actuator to a distal most position; the actuator has at least one actuator angled surface; the lock-out mechanism is affixed to the feed bar, the member having at least one member angled surface, wherein as the actuator retracts proximally the at least one actuator angled surface engages said member angled surface, wherein said engagement prevents said actuator from retracting proximal to said proximal most position thereby preventing re-actuation of the apparatus subsequent to the application of a final surgical clip.