A compound of formula wherein said compound is a compound of any one of the formula to and wherein R 1 is preferably wherein R 5 is C -R 8, wherein R 8 is independently at each occurrence selected from phenyl, naphthalene, 1,2-dihydronapthalenyl, 1,2,3,4-tetrahydronaphthenyl, pyridinyl, pyrazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, quinolinyl, isoquinolinyl, indolyl, piperidinyl, morpholinyl, pyrrolidinyl, benzimidazolyl, benzofuranyl, benzopyranyl, coumarinyl, pyridazinyl, isoindolyl, benzothiophenyl, benzooxazolyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, adamantanyl; each independently optionally substituted with C 1 -C 4 alkyl, halogen preferably fluorine, CF 3, OR 10, NR 11 R 12; wherein R 10, R 11, R 12 are independently at each occurrence H, C 1 -C 3 alkyl; and wherein R 21 is selected from H, C 1 -C 4 alkyl; and wherein the arrow indicates the attachment to the NH-moiety depicted in formula; R 2 is selected from wherein R indicates the attachment to the CH-moiety depicted in formula; R 3 is selected from wherein R indicates the attachment to the CH-moiety depicted in formula R 4 is wherein R 37, R 38, R 39 and R 40 are independently at each occurrence H or C 1 -C 3 alkyl, preferably H or methyl, or independently at each occurrence two of said R 37, R 38, R 39 and R 40 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring, preferably a carbocyclic ring, and wherein R 41 and R 42 are independently of each other H or C 1 -C 4 alkyl optionally substituted with halogen, hydroxyl or C 3 -C 6 cycloalkyl; or together with the nitrogen atom to which they are attached form independently at each occurrence a heteroaryl or a heterocyclyl, each independently optionally substituted with halogen, C 1 -C 4 alkyl, OR 43, NR 44 R 45; wherein the arrow indicates the attachment to the C -moiety depicted in formula; and pharmaceutically acceptable salts of said compound of formula. R 1 is preferably wherein R 5 is C -R 8, wherein R 8 is independently at each occurrence selected from phenyl, naphthalene, 1,2-dihydronapthalenyl, 1,2,3,4-tetrahydronaphthenyl, pyridinyl, pyrazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, quinolinyl, isoquinolinyl, indolyl, piperidinyl, morpholinyl, pyrrolidinyl, benzimidazolyl, benzofuranyl, benzopyranyl, coumarinyl, pyridazinyl, isoindolyl, benzothiophenyl, benzooxazolyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, adamantanyl; each independently optionally substituted with C 1 -C 4 alkyl, halogen preferably fluorine, CF 3, OR 10, NR 11 R 12; wherein R 10, R 11, R 12 are independently at each occurrence H, C 1 -C 3 alkyl; and wherein R 21 is selected from H, C 1 -C 4 alkyl; and wherein the arrow indicates the attachment to the NH-moiety depicted in formula; R 5 is C -R 8, wherein R 8 is independently at each occurrence selected from phenyl, naphthalene, 1,2-dihydronapthalenyl, 1,2,3,4-tetrahydronaphthenyl, pyridinyl, pyrazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, quinolinyl, isoquinolinyl, indolyl, piperidinyl, morpholinyl, pyrrolidinyl, benzimidazolyl, benzofuranyl, benzopyranyl, coumarinyl, pyridazinyl, isoindolyl, benzothiophenyl, benzooxazolyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, adamantanyl; each independently optionally substituted with C 1 -C 4 alkyl, halogen preferably fluorine, CF 3, OR 10, NR 11 R 12; wherein R 10, R 11, R 12 are independently at each occurrence H, C 1 -C 3 alkyl; and wherein R 21 is selected from H, C 1 -C 4 alkyl; and wherein the arrow indicates the attachment to the NH-moiety depicted in formula; R 2 is selected from wherein R indicates the attachment to the CH-moiety depicted in formula; R 3 is selected from wherein R indicates the attachment to the CH-moiety depicted in formula R 4 is wherein R 37, R 38, R 39 and R 40 are independently at each occurrence H or C 1 -C 3 alkyl, preferably H or methyl, or independently at each occurrence two of said R 37, R 38, R 39 and R 40 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring, preferably a carbocyclic ring, and wherein R 41 and R 42 are independently of each other H or C 1 -C 4 alkyl optionally substituted with halogen, hydroxyl or C 3 -C 6 cycloalkyl; or together with the nitrogen atom to which they are attached form independently at each occurrence a heteroaryl or a heterocyclyl, each independently optionally substituted with halogen, C 1 -C 4 alkyl, OR 43, NR 44 R 45; wherein the arrow indicates the attachment to the C -moiety depicted in formula; R 37, R 38, R 39 and R 40 are independently at each occurrence H or C 1 -C 3 alkyl, preferably H or methyl, or independently at each occurrence two of said R 37, R 38, R 39 and R 40 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring, preferably a carbocyclic ring, and wherein R 41 and R 42 are independently of each other H or C 1 -C 4 alkyl optionally substituted with halogen, hydroxyl or C 3 -C 6 cycloalkyl; or together with the nitrogen atom to which they are attached form independently at each occurrence a heteroaryl or a heterocyclyl, each independently optionally substituted with halogen, C 1 -C 4 alkyl, OR 43, NR 44 R 45; wherein and pharmaceutically acceptable salts of said compound of formula.