A process for the industrial preparation of ( -3-([1,1'-biphenyl]-4-yl)-2-((( -1-aminoethyl)(hydroxy)phosphoryl)methyl)propanoyl)-L-alanine acid of the following formula: comprising the following steps of: preparing the compound of the following formula: by: reacting -1-phenylethylamine in a polar and protic solvent with an aqueous solution of hypophosphorous acid H 3 PO 2 and acetaldehyde in the presence of one molar equivalent of hydrochloric acid relative to -1-phenylethylamine, then treating the salt resulting from step with propylene oxide, then crystallising using a polar and protic solvent and recovering the compound of the formula by filtration, preparing the compound of the following formula: by: reacting the compound of formula resulting from step with (2-(4-biphenyl)methyl)acrylate benzyl ester in the presence of a source of trimethylsilyl groups, then recovering the compound of formula by: (2b.1) crystallising using a mixture of apolar aprotic solvent and water then filtering, or (2b.2) triturating in acetone, filtering and evaporating the filtrate, preparing the compound of the following formula: wherein P' is a protective group of an amine function, by: hydrogenolysing the compound of the formula under hydrogen atmosphere in the presence of 10% by weight of Pd/C relative to the weight of the compound of the formula, then protecting the amine resulting from step with a protective group P' and recovering the compound of formula, preparing the compound of formula by peptidic coupling of the compound of formula with -alanine tert-butyl ester and recovering the compound of the following formula: deprotecting the protective group P' in the N-terminal position and the tert -butyl group in the C-terminal position and recovering the compound of formula. preparing the compound of the following formula: by: reacting -1-phenylethylamine in a polar and protic solvent with an aqueous solution of hypophosphorous acid H 3 PO 2 and acetaldehyde in the presence of one molar equivalent of hydrochloric acid relative to -1-phenylethylamine, then treating the salt resulting from step with propylene oxide, then crystallising using a polar and protic solvent and recovering the compound of the formula by filtration, reacting -1-phenylethylamine in a polar and protic solvent with an aqueous solution of hypophosphorous acid H 3 PO 2 and acetaldehyde in the presence of one molar equivalent of hydrochloric acid relative to -1-phenylethylamine, then treating the salt resulting from step with propylene oxide, then crystallising using a polar and protic solvent and recovering the compound of the formula by filtration, preparing the compound of the following formula: by: reacting the compound of formula resulting from step with (2-(4-biphenyl)methyl)acrylate benzyl ester in the presence of a source of trimethylsilyl groups, then recovering the compound of formula by: (2b.1) crystallising using a mixture of apolar aprotic solvent and water then filtering, or (2b.2) triturating in acetone, filtering and evaporating the filtrate, reacting the compound of formula resulting from step with (2-(4-biphenyl)methyl)acrylate benzyl ester in the presence of a source of trimethylsilyl groups, then recovering the compound of formula by: (2b.1) crystallising using a mixture of apolar aprotic solvent and water then filtering, or (2b.2) triturating in acetone, filtering and evaporating the filtrate, (2b.1) crystallising using a mixture of apolar aprotic solvent and water then filtering, or (2b.2) triturating in acetone, filtering and evaporating the filtrate, preparing the compound of the following formula: wherein P' is a protective group of an amine function, by: hydrogenolysing the compound of the formula under hydrogen atmosphere in the presence of 10% by weight of Pd/C relative to the weight of the compound of the formula, then protecting the amine resulting from step with a protective group P' and recovering the compound of formula, hydrogenolysing the compound of the formula under hydrogen atmosphere in the presence of 10% by weight of Pd/C relative to the weight of the compound of the formula, then protecting the amine resulting from step with a protective group P' and recovering the compound of formula, preparing the compound of formula by peptidic coupling of the compound of formula with -alanine tert-butyl ester and recovering the compound of the following formula: deprotecting the protective group P' in the N-terminal position and the tert -butyl group in the C-terminal position and recovering the compound of formula. peptidic coupling of the compound of formula with -alanine tert-butyl ester and recovering the compound of the following formula: deprotecting the protective group P' in the N-terminal position and the tert -butyl group in the C-terminal position and recovering the compound of formula.