mhurhangee/ep-ind-claims huggingface dataset:
An in vitro cell-based screening method to identify compounds effective in the treatment of cancer characterized by cells that are characterized by an over-activated signalling pathway, in a combination medicament with an inhibitor of said signalling pathway comprising the steps of a) providing a cell that carries an activating mutation or amplification in a gene encoding a protein comprised in said signalling pathway; b) bringing said cell in contact with i. an inhibitor of said signalling pathway; and ii. a test compound; c) determining an expression level of SOX2 and/or a gene under transcriptional control of SOX2; and d) assigning to said test compound a score, wherein i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold; wherein the gene under transcriptional control of SOX2 is selected from the group consisting of Nanog, OCT4, FGF4, FBX15, FOXP4, KLF9, CD24, CD271, CD36, ITLN2, TNFSF12, NOX3, CLEC7A, ACYAP1, UNC5C, UNC5D, MUC16, VAV3, FOXD3, VGLL3, ALPP, C3, F2R, ENPP2, ETV4, NTNG1, NTRK2, ROBO1 and ROBO2. a) providing a cell that carries an activating mutation or amplification in a gene encoding a protein comprised in said signalling pathway; b) bringing said cell in contact with i. an inhibitor of said signalling pathway; and ii. a test compound; i. an inhibitor of said signalling pathway; and ii. a test compound; c) determining an expression level of SOX2 and/or a gene under transcriptional control of SOX2; and d) assigning to said test compound a score, wherein i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold; i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold;
A pericardial modification device comprising a shaft and an incisor, wherein the incisor comprises a tip and a cutting portion, and wherein the device is a reverse cutting device, wherein the cutting portion is sharpened for shearing pericardial tissue, and wherein the device includes nerve stimulation capabilities from a pacing probe. wherein the cutting portion is sharpened for shearing pericardial tissue, and wherein the device includes nerve stimulation capabilities from a pacing probe.
Selective 5-HT2A serotonin receptor inverse agonist or antagonist, or a pharmaceutically acceptable salt thereof, for use in a method of delaying the onset and/or preventing Alzheimer's disease by reducing the concentration of Aβ peptides (Aβ) in a subject, wherein the concentration is in the brain of the subject; said method comprising administering an effective amount of a selective 5-HT2A serotonin receptor inverse agonist or antagonist or a pharmaceutically acceptable salt thereof to the subject in need thereof.
A radiopharmaceutical composition comprising: (i) the 99m Tc complex of tetrofosmin in a biocompatible carrier; (ii) tetrofosmin; and, (iii) a radioprotectant chosen from ascorbic acid or a salt thereof with a biocompatible cation; wherein the molar ratio of tetrofosmin (i) + (ii) to radioprotectant (iii) is in the range 0.2:1.0 to 1.0:1.0. (i) the 99m Tc complex of tetrofosmin in a biocompatible carrier; (ii) tetrofosmin; and, (iii) a radioprotectant chosen from ascorbic acid or a salt thereof with a biocompatible cation;
A train comprising a wireless communication system comprising a communication unit arranged inside said train; an antenna provided on or above an exterior metal surface of the train; a power cable connecting the antenna to the communication unit; a data transferring path connecting the antenna to the communication unit, for transfer of data there between; and a protective shield being formed of a conductive material and being electrically and mechanically bonded to the exterior metal surface of the train, wherein the shield comprises a cavity for accommodation of the antenna, and at least one waveguide extending through the protective shield and into said cavity, thereby enabling radio frequency waves to pass through the protective shield into and out from said antenna, wherein the at least one waveguide comprises a plurality of waveguides extending in parallel with each other, characterized in that the plurality of waveguides is provided in two or more planes being essentially parallel to the exterior metal surface, thereby forming rows and columns of waveguides. a communication unit arranged inside said train; an antenna provided on or above an exterior metal surface of the train; a power cable connecting the antenna to the communication unit; a data transferring path connecting the antenna to the communication unit, for transfer of data there between; and a protective shield being formed of a conductive material and being electrically and mechanically bonded to the exterior metal surface of the train, wherein the shield comprises a cavity for accommodation of the antenna, and at least one waveguide extending through the protective shield and into said cavity, thereby enabling radio frequency waves to pass through the protective shield into and out from said antenna, wherein the at least one waveguide comprises a plurality of waveguides extending in parallel with each other, characterized in that the plurality of waveguides is provided in two or more planes being essentially parallel to the exterior metal surface, thereby forming rows and columns of waveguides.
A wear-resistant member comprising a Cr-based alloy material, wherein the Cr-based alloy material has an alloy composition consisting of: more than 40 mass% and 65 mass% or less of Cr; 15 mass% or more and 40 mass% or less of Ni; more than 0 mass% and 30 mass% or less of Fe; 5 mass% or more and 16 mass% or less of Nb; 0.1 mass% or more and 0.9 mass% or less of Ti; 0.6 mass% or more and 2.5 mass% or less of C; 2 mass% or less of Mn; optionally, at least one of: 0.1 mass% or more and 5 mass% or less of Cu; 0.1 mass% or more and 1 mass% or less of Si; 0.02 mass% or more and 0.3 mass% or less of Sn; and 0.005 mass% or more and 0.05 mass% or less of Al; and 1 mass% or less in total of impurities including 0.04 mass% or less of N, 0.02 mass% or less of O, 0.04 mass% or less of P, 0.005 mass% or less of S and 0.2 mass% or less of Ta, wherein a mass ratio Ti/Nb of the Nb and the Ti is 0.063 or less. more than 40 mass% and 65 mass% or less of Cr; 15 mass% or more and 40 mass% or less of Ni; more than 0 mass% and 30 mass% or less of Fe; 5 mass% or more and 16 mass% or less of Nb; 0.1 mass% or more and 0.9 mass% or less of Ti; 0.6 mass% or more and 2.5 mass% or less of C; 2 mass% or less of Mn; optionally, at least one of: 0.1 mass% or more and 5 mass% or less of Cu; 0.1 mass% or more and 1 mass% or less of Si; 0.02 mass% or more and 0.3 mass% or less of Sn; and 0.005 mass% or more and 0.05 mass% or less of Al; and 1 mass% or less in total of impurities including 0.04 mass% or less of N, 0.02 mass% or less of O, 0.04 mass% or less of P, 0.005 mass% or less of S and 0.2 mass% or less of Ta, wherein a mass ratio Ti/Nb of the Nb and the Ti is 0.063 or less.
An optical apparatus, comprising: a semiconductor substrate; a dielectric layer located on the semiconductor substrate, wherein a membrane portion of the dielectric layer is located over a cavity (125; 125a) in a surface of the semiconductor substrate; a resistive heater (130; 130a) located on the membrane portion, the resistive heater being controllable by a current applied to the resistive heater; and an etalon optical filter (140; 140a) located on the resistive heater and over the cavity, an optical passband of the etalon optical filter being wavelength tunable by the resistive heater; characterised in that the etalon optical filter (140; 140a) includes a silicon slab being upright on the dielectric layer, wherein the silicon slab is coated on two opposite sides that are oriented perpendicular to the dielectric layer with partially reflective material layers. a semiconductor substrate; a dielectric layer located on the semiconductor substrate, wherein a membrane portion of the dielectric layer is located over a cavity (125; 125a) in a surface of the semiconductor substrate; a resistive heater (130; 130a) located on the membrane portion, the resistive heater being controllable by a current applied to the resistive heater; and an etalon optical filter (140; 140a) located on the resistive heater and over the cavity, an optical passband of the etalon optical filter being wavelength tunable by the resistive heater; characterised in that the etalon optical filter (140; 140a) includes a silicon slab being upright on the dielectric layer, wherein the silicon slab is coated on two opposite sides that are oriented perpendicular to the dielectric layer with partially reflective material layers.
A method of determining which of a plurality of different target nucleic acids are present in a test sample, the method comprising the steps of: (a) in a reaction mixture containing nucleic acids from the test sample, serially permitting, in order, first and second secondary reactions of a multiplex invasive cleavage assay to take place, each of the secondary reactions being active under a different temperature condition, and each secondary reaction being specific for only one of the target nucleic acids; (b) monitoring the reaction mixture for production of a fluorescent signal only as the second of the two secondary reactions is taking place at the lower of two temperature conditions, each of the different temperature conditions being permissive for only one of the secondary reactions, and each of the secondary reactions producing the same fluorescent signal; and (c) determining which of the target nucleic acids is present in the test sample by comparing a magnitude of the fluorescent signal produced in the reaction mixture during step (b) with a threshold value or threshold criterion. (a) in a reaction mixture containing nucleic acids from the test sample, serially permitting, in order, first and second secondary reactions of a multiplex invasive cleavage assay to take place, each of the secondary reactions being active under a different temperature condition, and each secondary reaction being specific for only one of the target nucleic acids; (b) monitoring the reaction mixture for production of a fluorescent signal only as the second of the two secondary reactions is taking place at the lower of two temperature conditions, each of the different temperature conditions being permissive for only one of the secondary reactions, and each of the secondary reactions producing the same fluorescent signal; and (c) determining which of the target nucleic acids is present in the test sample by comparing a magnitude of the fluorescent signal produced in the reaction mixture during step (b) with a threshold value or threshold criterion.
A noise reduction device (10, 10x) comprising: - a noise detector to detect electromagnetic noise on a connection line; - a compensation signal generator to generate a compensation signal (icmp) for canceling the electromagnetic noise on the basis of a detection signal (vsns) of the noise detector; - a compensation signal injector to inject the compensation signal (icmp) into the connection line; - a compensation signal detector to detect the compensation signal (icmp); characterised by - a low-frequency component subtraction unit to amplify a frequency component in a first frequency region that is lower than a predetermined first frequency in a detection signal (vcmp) detected by the compensation signal detector, and to negatively feed back the amplified frequency component to the compensation signal generator; and - an intermediate frequency component addition unit to positively feed back a component of a predetermined second frequency that is higher than the first frequency in the detection signal (vcmp) detected by the compensation signal detector to the compensation signal generator, wherein the noise detector detects the electromagnetic noise to which the compensation signal (icmp) is injected by the compensation signal injector on the connection line. - a noise detector to detect electromagnetic noise on a connection line; - a compensation signal generator to generate a compensation signal (icmp) for canceling the electromagnetic noise on the basis of a detection signal (vsns) of the noise detector; - a compensation signal injector to inject the compensation signal (icmp) into the connection line; - a compensation signal detector to detect the compensation signal (icmp); characterised by - a low-frequency component subtraction unit to amplify a frequency component in a first frequency region that is lower than a predetermined first frequency in a detection signal (vcmp) detected by the compensation signal detector, and to negatively feed back the amplified frequency component to the compensation signal generator; and - an intermediate frequency component addition unit to positively feed back a component of a predetermined second frequency that is higher than the first frequency in the detection signal (vcmp) detected by the compensation signal detector to the compensation signal generator, wherein
A screen assembly adapted to be applied to an electronic device, comprising: at least one light-transmitting layer capable of transmitting light, an optical surface structure being formed at a part of the at least one light-transmitting layer such that a first lens element is formed at the part of the at least one light-transmitting layer, wherein the first lens element is adapted to serve as a lens element of a camera module of the electronic device, wherein the screen assembly comprises at least one blind hole adapted to accommodate the camera module, and the optical surface structure is located at a position of the at least one light-transmitting layer corresponding to the at least one blind hole; wherein the screen assembly is an LCD assembly which comprises a first cover plate, a first polarizer, a first glass substrate, a liquid crystal layer, a second glass substrate, a second polarizer and a backlight layer laminated sequentially; and the at least one blind hole is formed by a through hole coaxially running through the backlight layer, the second polarizer, and the first polarizer sequentially, and the first glass substrate and the second glass substrate form the at least one light-transmitting layer, wherein the first glass substrate is provided with a color filter structure and the second glass substrate is provided with a TFT circuit, and the TFT circuit and the color filter structure are at a position corresponding to the first lens element. at least one light-transmitting layer capable of transmitting light, an optical surface structure being formed at a part of the at least one light-transmitting layer such that a first lens element is formed at the part of the at least one light-transmitting layer, wherein the first lens element is adapted to serve as a lens element of a camera module of the electronic device, wherein the screen assembly comprises at least one blind hole adapted to accommodate the camera module, and the optical surface structure is located at a position of the at least one light-transmitting layer corresponding to the at least one blind hole; wherein the screen assembly is an LCD assembly which comprises a first cover plate, a first polarizer, a first glass substrate, a liquid crystal layer, a second glass substrate, a second polarizer and a backlight layer laminated sequentially; and the at least one blind hole is formed by a through hole coaxially running through the backlight layer, the second polarizer, and the first polarizer sequentially, and the first glass substrate and the second glass substrate form the at least one light-transmitting layer, wherein the first glass substrate is provided with a color filter structure and the second glass substrate is provided with a TFT circuit, and the TFT circuit and the color filter structure are at a position corresponding to the first lens element.
Method for eliminating CO2 from a combined heat and power plant, characterized in that the gas flow which is expanded in a gas turbine is divided after a high-pressure turbine into a first part mass flow and a second part mass flow, the first part mass flow is expanded further performing expansion work, its waste heat usefully extracted and this first part mass flow is then recirculated into the intake flow of the gas turbine, and in that the second part mass flow is diverted as a take-off flow, cooled and the CO2 eliminated therefrom.
A parking assistance device comprising: an overhead image generating portion that generates an overhead image through viewpoint conversion from a captured image acquired by a camera that captures an image of surroundings of a vehicle; and a parking route generating portion that generates a parking route to a set parking target position; characterized by an attention region determining portion that determines an attention region to which attention is to be paid at the time of running to park based on a variation in curvature with progression along the parking route and in which a corner end of the vehicle swings out significantly from the parking route when the center of the vehicle moves along the parking route (k) and there is a higher possibility of the vehicle's touching with a nearby object and an image compositing portion that inputs, as a display image of the surroundings of the vehicle to be displayed on a monitor, an overhead image including the attention region that is in the overhead image generated by the overhead image generating portion, and generates a display overhead image by compositing a vehicle image at a vehicle position in the input overhead image. an overhead image generating portion that generates an overhead image through viewpoint conversion from a captured image acquired by a camera that captures an image of surroundings of a vehicle; and a parking route generating portion that generates a parking route to a set parking target position; characterized by an attention region determining portion that determines an attention region to which attention is to be paid at the time of running to park based on a variation in curvature with progression along the parking route and in which a corner end of the vehicle swings out significantly from the parking route when the center of the vehicle moves along the parking route (k) and there is a higher possibility of the vehicle's touching with a nearby object and an image compositing portion that inputs, as a display image of the surroundings of the vehicle to be displayed on a monitor, an overhead image including the attention region that is in the overhead image generated by the overhead image generating portion, and generates a display overhead image by compositing a vehicle image at a vehicle position in the input overhead image.
An aircraft with a fuselage that defines at least one drive system accommodating region, the drive system accommodating region accommodating at least one engine that generates a hot air flow in operation of the aircraft, wherein at least one hot air exhaust is provided for exhausting the generated hot air flow, the at least one hot air exhaust comprising at least one first exhaust section and at least one second exhaust section, the at least one second exhaust section being mounted in a rotatable manner to the at least one first exhaust section via an associated off-axis swivel joint, wherein an actuating member is provided, the actuating member being adapted for applying a turning moment to the at least one second exhaust section in operation of the aircraft in order to displace a longitudinal axis of the at least one second exhaust section with respect to a longitudinal axis of the at least one first exhaust section by a predetermined displacement angle, characterized in that the actuating member is adapted for applying the turning moment on the basis of a current operation temperature of the actuating member, wherein the actuating member comprises a temperature-sensitive actuator, the temperature-sensitive actuator being equipped with an expandable fluid, gas or rigid material that is adapted for expanding if the current operation temperature of the actuating member increases.