A polymer particle comprising one or more fusion polypeptides, wherein one or more of the fusion polypeptides comprises a particle-forming protein and two or more of the group comprising a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen, b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or a particle-forming protein and three or more of the group comprising a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, and e. an Rv2346c antigen or a binding domain capable of binding an Rv2346c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, and an Rv3615c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, and an Rv3615c antigen, wherein said fusion polypeptide has at least about 95% sequence identity to the amino acid sequence depicted in SEQ. ID. NO. 10, or a particle-forming protein and i. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; and ii. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen; and iii. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and iv. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, an Rv3615c antigen, and an Rv3020c antigen. a particle-forming protein and two or more of the group comprising a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen, b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen, b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or a particle-forming protein and three or more of the group comprising a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, and e. an Rv2346c antigen or a binding domain capable of binding an Rv2346c antigen, or a. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; b. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen, c. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, d. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, and e. an Rv2346c antigen or a binding domain capable of binding an Rv2346c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, and an Rv3615c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, and an Rv3615c antigen, wherein said fusion polypeptide has at least about 95% sequence identity to the amino acid sequence depicted in SEQ. ID. NO. 10, or a particle-forming protein and i. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; and ii. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen; and iii. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and iv. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or i. an ESAT6 antigen or a binding domain capable of binding an ESAT6 antigen; and ii. a CFP10 antigen or a binding domain capable of binding a CFP10 antigen; and iii. an Rv3615c antigen or a binding domain capable of binding an Rv3615c antigen, and iv. an Rv3020c antigen or a binding domain capable of binding an Rv3020c antigen, or a particle-forming protein, an ESAT6 antigen, a CFP10 antigen, an Rv3615c antigen, and an Rv3020c antigen.