mhurhangee/ep-ind-claims huggingface dataset:
A mutant microbial host cell which has been modified in its genome to result in a deficiency in the production of a polypeptide having α-amylase activity selected from the group consisting of: a. a polypeptide according to SEQ ID NO: 3 or 7 or a polypeptide at least 85% identical thereto; b. a mature polypeptide comprised in SEQ ID NO: 3 or 7 or a polypeptide at least 85% identical thereto; c. a polypeptide encoded by a polynucleotide according to SEQ ID NO: 1, 2, 5 or 6 or encoded by a polynucleotide at least 85% identical to SEQ ID NO: 1, 2, 5 or 6; wherein the modification comprises a modification which results in a reduced or no production of a polypeptide having α-amylase activity as defined in claim 1 a. to 1.c. if compared to the parent microbial host cell that has not been modified, when analysed under the same conditions, wherein the modification in its genome is selected from: a) a full or partial deletion of a polynucleotide as defined in claim 1 c.; b) a full or partial replacement of a polynucleotide as defined in claim 1 c. with a polynucleotide sequence which does not code for a polypeptide as defined in claim 1 a. to 1 c. or which code for a partially or fully inactive form of a polypeptide as defined in claim 1 a. to 1 c.; c) a disruption of a polynucleotide as defined in claim 1 c. by the insertion of one or more nucleotides in the polynucleotide sequence and consequent partial or full inactivation of the polypeptide as defined in claim 1 a. to 1 c., wherein the mutant microbial host cell is an Aspergillus niger cell and has been modified in its genome to result in a deficiency in the production of one or more of a polypeptide having glucoamylase glaA activity, a polypeptide having alpha-amylase amyBII activity, a polypeptide having amyBI activity and a polypeptide having acid stable alpha-amylase amyA activity, if compared with a parent microbial host cell which has not been modified and measured under the same conditions. a. a polypeptide according to SEQ ID NO: 3 or 7 or a polypeptide at least 85% identical thereto; b. a mature polypeptide comprised in SEQ ID NO: 3 or 7 or a polypeptide at least 85% identical thereto; c. a polypeptide encoded by a polynucleotide according to SEQ ID NO: 1, 2, 5 or 6 or encoded by a polynucleotide at least 85% identical to SEQ ID NO: 1, 2, 5 or 6; a) a full or partial deletion of a polynucleotide as defined in claim 1 c.; b) a full or partial replacement of a polynucleotide as defined in claim 1 c. with a polynucleotide sequence which does not code for a polypeptide as defined in claim 1 a. to 1 c. or which code for a partially or fully inactive form of a polypeptide as defined in claim 1 a. to 1 c.; c) a disruption of a polynucleotide as defined in claim 1 c. by the insertion of one or more nucleotides in the polynucleotide sequence and consequent partial or full inactivation of the polypeptide as defined in claim 1 a. to 1 c.,
Device for straightening a metal flat product by pressing, comprising: an upper press frame and a lower press frame, wherein the upper press frame comprises a pressure piston and the lower press frame comprises a table with a depression for entry of the pressure piston, or conversely, and wherein the upper press frame is arranged opposite the lower press frame and the two press frames are displaceable relative to one another; characterised in that the upper pressure frame has in the region of its two narrow sides carrier elements as points of engagement for a balancing device for the upper work roll in a roll stand; and the lower pressure frame has in the region of its two narrow sides support elements for supporting on the housings of the roll stand. an upper press frame and a lower press frame, wherein the upper press frame comprises a pressure piston and the lower press frame comprises a table with a depression for entry of the pressure piston, or conversely, and wherein the upper press frame is arranged opposite the lower press frame and the two press frames are displaceable relative to one another; characterised in that the upper pressure frame has in the region of its two narrow sides carrier elements as points of engagement for a balancing device for the upper work roll in a roll stand; and the lower pressure frame has in the region of its two narrow sides support elements for supporting on the housings of the roll stand.
A floor cleaning appliance comprising a main body including: • a case delimited at least partially by an external wall, • a fluid inlet intended to receive a fluid flow from outside the case, • at least one means, disposed in the case, intended to act on the fluid flow received through the fluid inlet; the cleaning appliance comprising at least two main wheels (10, 11) mounted movable in rotation on the main body, each main wheel (10, 11) having a tread (12, 13) so that the cleaning appliance can rest and roll on the floor to be cleaned, the main wheels (10, 11) being disposed on either side of the main body, characterised in that the cleaning appliance comprises a protective structure configured to protect the main wheels (10, 11), the protective structure being disposed outside the case and extending at a distance from the external wall, the protective structure covering a portion (12a, 13a) of the tread (12, 13) of each main wheel (10, 11). • a case delimited at least partially by an external wall, • a fluid inlet intended to receive a fluid flow from outside the case, • at least one means, disposed in the case, intended to act on the fluid flow received through the fluid inlet;
Method for compensating bounce effects in a piezo-controlled injection system of an internal combustion engine, having a control value which is actuated by a piezo actuator, having the following method steps: - detecting an actual bounce behaviour of the control value, and - determining and compensating a deviation between the actual bounce behaviour and a setpoint bounce behaviour of the control valve, wherein actuation information for the control valve, by which a speed characteristic of a needle of the control valve is influenced, is generated, wherein the speed characteristic of the needle is defined by a configuration of a holding phase in a charging and/or discharging process of the piezo actuator. - detecting an actual bounce behaviour of the control value, and - determining and compensating a deviation between the actual bounce behaviour and a setpoint bounce behaviour of the control valve,
A PACE4 inhibitor consisting of the following formula: Z-Xaa 8 -Xaa 7 -Xaa 6 -Xaa 5 -Arg 4 -Val 3 -Lys 2 -Arg 1 -NH 2; wherein - Arg 1 is an arginine; - Xaa 5, Xaa 6, Xaa 7 and Xaa 8 are Leu, Iso or Val; and - Z is absent or comprises an N-terminal acyl group linked to the N-terminal of the peptide sequence. - Arg 1 is an arginine; - Xaa 5, Xaa 6, Xaa 7 and Xaa 8 are Leu, Iso or Val; and - Z is absent or comprises an N-terminal acyl group linked to the N-terminal of the peptide sequence.
A shelf for a roll container, the shelf comprising: - a first end, - a second end opposing the first end, - pivoting means provided to the first end of the shelf for pivoting the shelf to a frame profile of a first wall of the roll container between a horizontal load carrying configuration and a vertical folding configuration, and - locking means (221, 222) provided to the second end of the shelf for resting the shelf in a load carrying orientation to a second wall of the roll container disposed at a distance from and opposing the first wall, wherein the locking means (221, 222) is also configured to engage with a horizontal element of the first wall for suspending the shelf from the horizontal element of the first wall, when the shelf is in the vertical folding configuration, characterized in that said pivoting means comprises: - two slide members opposing each other at the first end of the shelf, which slide members are shaped to at least partly envelop a vertical section of a frame profile of the first wall of the roll container so as to slide along corresponding opposing vertical sections of the frame profile of the first wall, whereby the shelf may be retrofitted to the roll container, - an axle connected to at least one of said slide members to extend towards the other hinge member such to create an axis of revolution for the shelf, and - a limiter connected to the axle, the limiter being configured to be rotated about said axis of revolution in respect to said at least one slide member and to engage with a horizontal element of the first wall for positioning the shelf vertically into the load carrying configuration. - a first end, - a second end opposing the first end, - pivoting means provided to the first end of the shelf for pivoting the shelf to a frame profile of a first wall of the roll container between a horizontal load carrying configuration and a vertical folding configuration, and - locking means (221, 222) provided to the second end of the shelf for resting the shelf in a load carrying orientation to a second wall of the roll container disposed at a distance from and opposing the first wall, wherein the locking means (221, 222) is also configured to engage with a horizontal element of the first wall for suspending the shelf from the horizontal element of the first wall, when the shelf is in the vertical folding configuration, - two slide members opposing each other at the first end of the shelf, which slide members are shaped to at least partly envelop a vertical section of a frame profile of the first wall of the roll container so as to slide along corresponding opposing vertical sections of the frame profile of the first wall, whereby the shelf may be retrofitted to the roll container, - an axle connected to at least one of said slide members to extend towards the other hinge member such to create an axis of revolution for the shelf, and - a limiter connected to the axle, the limiter being configured to be rotated about said axis of revolution in respect to said at least one slide member and to engage with a horizontal element of the first wall for positioning the shelf vertically into the load carrying configuration.
A phosphor given by a general composition formula expressed by MmAaBbOoNn:Z, wherein element M is one or more kinds of elements having bivalent valency, element A is one or more kinds of elements having tervalent valency, element B is one or more kinds of elements having tetravalent valency containing at least Si, O is oxygen, N is nitrogen, and element Z is one or more kinds of activating agent, satisfying m > 0, a > 0, b > 0, o ≥ 0, n > 0, 0 ≤ a/m ≤ 2.0,4.0 ≤ b/m ≤ 8.0, 6.0 ≤ (a + b)/m ≤ 8.0, 0 < o/m ≤ 3.0, a = x × m, b = (6 - x) × m, o = (1 + x) × m, n = (8 - x) × m when satisfying 0 < x ≤ 2, wherein when the ratio of element B atoms to total numbers of atoms in a depth of 50 nm from a particle surface is set at M 50 at%, and the ratio of the element B atoms to the total numbers of atoms in a depth of d nm which is obtained by measuring a range of the depth from 50 nm to 1950 nm from the particle surface at an interval of 100 nm by ESCA (Electron spectroscopy for Chemical Analysis) is set at M d at%, a value of M d obtained by measuring the range of the depth from 50 nm to 1950 nm from the particle surface at an interval of 100 nm by ESCA satisfies: − 10 < M B d − M B 50 / M B 50 × 100 < 10, wherein the element M is one or more kinds of elements selected from the group consisting of Mg, Ca, Sr, Ba, and Zn, the element A is one or more kinds of elements selected from the group consisting of Al, Ga, and In, the element B is Si and optionally Ge, and the element Z is one or more kinds of elements selected from the group consisting of Eu, Ce, Pr, Tb, Yb, and Mn.
Belt arrangement for a vehicle seat, having a belt strap and at least one deflection element for the belt strap, which is arranged on a movably mounted holding device and ties a passenger on the vehicle seat, in an accident situation, to the vehicle seat and retains said passenger in the vehicle seat, wherein the holding device is mounted so as to rotate about a pivot point on a body element, wherein a drive rotates the holding device about the pivot point and changes a profile of the belt strap in order to influence the retention properties, wherein an orientation of the holding device is dependent on a current inclination of a corresponding backrest (2.2) of the vehicle seat, such that a position change of the backrest (2.2) in the vehicle longitudinal direction (x) and in the vehicle vertical direction (z) can be compensated for by the holding device during driving.
A flexible steerable guidewire for facilitating placement of a medical implement, the guidewire comprising: an elongate body comprising a proximal section, an intermediate section, and a distal steerable section, characterized in that the flexible steerable guidewire further comprises a plurality of rotatable swivel members (504, 506, 508) longitudinally disposed along the elongate body and wherein the distal steerable section comprises a distalmost rotatable swivel member, and an elongate directional tip extending distally from the distalmost swivel member; at least one manipulation wire (524a, 524b) secured to the swivel members and extending proximally to the proximal section; and wherein the at least one manipulation wire is axially movably disposed such that axial movement of the manipulation wire rotates the swivel members, thereby curving the elongate body and deflecting the directional tip. an elongate body comprising a proximal section, an intermediate section, and a distal steerable section, characterized in that the flexible steerable guidewire further comprises a plurality of rotatable swivel members (504, 506, 508) longitudinally disposed along the elongate body and wherein the distal steerable section comprises a distalmost rotatable swivel member, and an elongate directional tip extending distally from the distalmost swivel member; at least one manipulation wire (524a, 524b) secured to the swivel members and extending proximally to the proximal section; and wherein the at least one manipulation wire is axially movably disposed such that axial movement of the manipulation wire rotates the swivel members, thereby curving the elongate body and deflecting the directional tip.
An intraluminal sensing device, comprising: a guidewire configured to be positioned within a body lumen of a patient, wherein the guidewire comprises: a core wire; a first insulative coating covering at least a portion of a circumference of the core wire along at least a portion of a length of the core wire; at least two conductive traces (660a, 660b), each comprising a thickness and a width and extending longitudinally along at least the portion of the length of the core wire over an outer surface of the first insulative coating, wherein each conductive trace comprises a cross-sectional shape conforming to a curvature of the first insulative coating, wherein the at least two conductive traces and the core wire are insulated from one another; and a second insulative coating covering an outer surface of the at least two conductive traces along at least the portion of the length of the core wire; a sensor configured to obtain physiological data while positioned within the body lumen, wherein the sensor is positioned at a distal portion of the guidewire and in electrical communication with the at least two conductive traces; and a connector positioned at a proximal portion of the guidewire and in electrical communication with the at least two conductive traces. a core wire; a first insulative coating covering at least a portion of a circumference of the core wire along at least a portion of a length of the core wire; at least two conductive traces (660a, 660b), each comprising a thickness and a width and extending longitudinally along at least the portion of the length of the core wire over an outer surface of the first insulative coating, wherein each conductive trace comprises a cross-sectional shape conforming to a curvature of the first insulative coating, wherein the at least two conductive traces and the core wire are insulated from one another; and a second insulative coating covering an outer surface of the at least two conductive traces along at least the portion of the length of the core wire; a sensor configured to obtain physiological data while positioned within the body lumen, wherein the sensor is positioned at a distal portion of the guidewire and in electrical communication with the at least two conductive traces; and a connector positioned at a proximal portion of the guidewire and in electrical communication with the at least two conductive traces.
Hand-held machine tool for sanding or polishing a workpiece, the machine tool comprising - a housing and - a working element adapted for performing an orbital or a random orbital movement in respect to the housing, and the machine tool further comprises in the housing - a motor with a motor shaft adapted for performing a rotational movement around an axis of rotation, and - means (7, 8) for transforming the rotational movement of the shaft into the orbital or a random orbital movement of the working element, characterized in that the working element is supported in respect to the machine tool's housing such that it is able to rotate around a longitudinal axis in respect to the housing, in that the housing comprises a plurality of magnetic elements facing the working element and in that the working element comprises a plurality of corresponding magnetic elements facing the housing, wherein the magnetic elements of the housing on the one hand and the magnetic elements of the working element on the other hand are adapted to interact with one another, in order to hold the working element in a desired rotational position in respect to the housing by means of magnetic force, wherein a gap is provided between the working element and the housing providing clearance and allowing a free rotation between the two around the longitudinal axis, the rotation restricted or limited only by the magnetic force effective between the magnetic elements of the housing on the one hand and the respective magnetic elements of the working element on the other hand. - a housing and - a working element adapted for performing an orbital or a random orbital movement in respect to the housing, and the machine tool further comprises in the housing - a motor with a motor shaft adapted for performing a rotational movement around an axis of rotation, and - means (7, 8) for transforming the rotational movement of the shaft into the orbital or a random orbital movement of the working element,
An unmanned aerial vehicle path planning method, comprising: acquiring a horizontal depth map of an environment in front of a UAV characterized by determining whether the UAV has an angle of pitch and performing depth compensation on the depth map if the UAV has the angle of pitch; acquiring a grid map centered about the body of the UAV according to the depth map after the depth compensation; determining candidate flight directions for the UAV according to the grid map; determining an optimal flight direction for the UAV from the candidate flight directions; and controlling the UAV to fly in the optimal flight direction to avoid an obstacle in the environment in front of the UAV. acquiring a horizontal depth map of an environment in front of a UAV characterized by determining whether the UAV has an angle of pitch and performing depth compensation on the depth map if the UAV has the angle of pitch; acquiring a grid map centered about the body of the UAV according to the depth map after the depth compensation; determining candidate flight directions for the UAV according to the grid map; determining an optimal flight direction for the UAV from the candidate flight directions; and controlling the UAV to fly in the optimal flight direction to avoid an obstacle in the environment in front of the UAV.
An apparatus comprising transceiving means connected to a first network node by a first downlink carrier and to at least a second network node by at least a second downlink carrier, and for providing only a single carrier to be available in an uplink direction; controlling means for controlling the transceiver such that the single carrier available in the uplink direction is shared among a first uplink carrier to the first network node and at least a second uplink carrier to the at least second network node; and, wherein the sharing among the first and second uplink carriers comprises sharing of uplink control signalling in a time divisional multiplexed manner.
A system comprising: - a cryogenic liquid storage tank; - a first pressure tank and a second pressure tank, both connected via leads to the storage tank; - at least one ejector (130, 140, 230), characterized by - each of the at least one ejector (130, 140, 230) being connected via leads to both pressure tanks (110, 120), and by - a controller, the controller being configured to admit cryogenic fluid from the storage tank to the first pressure tank, to cause the cryogenic fluid to be heated to convert it into gas form, and to admit the fluid in gas form from the first pressure tank through a first ejector from among the at least one ejector (130, 140, 230), such that the fluid in gas form acts as a motive fluid to cause evacuation of the second pressure tank as it passes through the first ejector. - a cryogenic liquid storage tank; - a first pressure tank and a second pressure tank, both connected via leads to the storage tank; - at least one ejector (130, 140, 230), - each of the at least one ejector (130, 140, 230) being connected via leads to both pressure tanks (110, 120), and by - a controller, the controller being configured to admit cryogenic fluid from the storage tank to the first pressure tank, to cause the cryogenic fluid to be heated to convert it into gas form, and to admit the fluid in gas form from the first pressure tank through a first ejector from among the at least one ejector (130, 140, 230), such that the fluid in gas form acts as a motive fluid to cause evacuation of the second pressure tank as it passes through the first ejector.
A liquid formulation of a therapeutic agent comprising: rapamycin (sirolimus), CCI-779, ABT-578 and everolimus in a pharmaceutically effective dosage; ethanol; and Vitamin E d-alpha tocopheryl polyethyleneglycol succinate (Vitamin E TPGS), characterized in that said ethanol is present at a concentration of less than 2% and said Vitamin E TPGS is present in a larger amount than said ethanol. rapamycin (sirolimus), CCI-779, ABT-578 and everolimus in a pharmaceutically effective dosage; ethanol; and Vitamin E d-alpha tocopheryl polyethyleneglycol succinate (Vitamin E TPGS),
A trench shoring apparatus, comprising: first and second side panels (12a, 12b) connected in a parallel spaced-apart configuration by a connecting rod pivotally connected to one end of one or more pairs of lateral arms, the other opposite end of the one or more pairs of lateral arms being hingedly connected to the side panels (12a, 12b), characterised in that translational movement of the connecting rod in a direction parallel to the side panels (12a, 12b) causes the spaced-apart panels (12a, 12b) to move between retracted and extended parallel spaced-apart configurations.