Microscope comprising - an illumination device with which a light sheet for illuminating a sample region is generated, which has an approximately planar extension in the direction of an illumination axis of an illumination beam path and in the direction of a transverse axis which lies transversely to the illumination axis, - a detection device with which light is detected, which is radiated from the sample region along a detection axis of a detection beam path, wherein illumination axis and detection axis as well as transverse axis and detection axis are at an angle different from zero to each other, - the illumination device comprising means for deflecting illumination light into a further illumination beam path and for generating a further light sheet which has an approximately planar extension in the direction of the illumination axis and in the direction of the transverse axis, wherein the illumination beam path and the further illumination beam path are composed of substantially identical optical elements and have the same optical path lengths, and wherein the light sheet and the further light sheet are aligned with each other such that they illuminate the sample region on the same illumination axis from opposite directions, - the illumination device additionally comprising switching means for switching the illumination light between the illumination beam path and the further illumination beam path, - the detection device comprising a detection objective for the imaging of light radiated from the sample region onto a spatially resolving surface detector for the location-dependent detection of the light, characterized in that - the switching means comprise a rapidly switchable switching element with a switching time of less than 10 ms, wherein a predefined integration time of the surface detector and the switching time of the switching element are coordinated with each other such that, during the integration time, the sample region is illuminated at least once from each direction on the illumination axis, with the result that, in an image, the sample effectively appears to be illuminated from both directions. - an illumination device with which a light sheet for illuminating a sample region is generated, which has an approximately planar extension in the direction of an illumination axis of an illumination beam path and in the direction of a transverse axis which lies transversely to the illumination axis, - a detection device with which light is detected, which is radiated from the sample region along a detection axis of a detection beam path, wherein illumination axis and detection axis as well as transverse axis and detection axis are at an angle different from zero to each other, - the illumination device comprising means for deflecting illumination light into a further illumination beam path and for generating a further light sheet which has an approximately planar extension in the direction of the illumination axis and in the direction of the transverse axis, wherein the illumination beam path and the further illumination beam path are composed of substantially identical optical elements and have the same optical path lengths, and wherein the light sheet and the further light sheet are aligned with each other such that they illuminate the sample region on the same illumination axis from opposite directions, - the illumination device additionally comprising switching means for switching the illumination light between the illumination beam path and the further illumination beam path, - the detection device comprising a detection objective for the imaging of light radiated from the sample region onto a spatially resolving surface detector for the location-dependent detection of the light, characterized in that - the switching means comprise a rapidly switchable switching element with a switching time of less than 10 ms, wherein a predefined integration time of the surface detector and the switching time of the switching element are coordinated with each other such that, during the integration time, the sample region is illuminated at least once from each direction on the illumination axis, with the result that, in an image, the sample effectively appears to be illuminated from both directions.