mhurhangee/ep-ind-claims huggingface dataset:
An ENPP1 inhibitor of the formula: wherein, X is a hydrophilic head group selected from phosphonic acid, phosphonate, phosphonate ester, phosphate, phosphate ester, thiophosphate, thiophosphate ester, phosphoramidate and thiophosphoramidate; L is selected from -CH 2 -, -(CH 2) 2 -, -(CH 2) 3 -, -(CH 2) 4 -, -(CH 2) 5 - and -(CH 2) 6 -; Z 1 and Z 2 are each independently selected from CR 1 and N; Z 3 and Z 4 are each independently selected from CR and N, wherein R is H, alkyl or substituted alkyl; each R 1 is independently selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycle and substituted heterocycle; R 2 and R 5 are each independently selected from H, OH, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, -OCF 3, halogen, amine, substituted amine, amide, heterocycle and substituted heterocycle; R 3 and R 4 are each independently selected from H, OH, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, -OCF 3, halogen, amine, substituted amine, amide, heterocycle and substituted heterocycle; or R 3 and R 4 together with the carbon atoms to which they are attached form a fused ring selected from heterocycle, substituted heterocycle, cycloalkyl, substituted cycloalkyl, aryl and substituted aryl; or a pharmaceutically acceptable salt or a solvate thereof. X is a hydrophilic head group selected from phosphonic acid, phosphonate, phosphonate ester, phosphate, phosphate ester, thiophosphate, thiophosphate ester, phosphoramidate and thiophosphoramidate; L is selected from -CH 2 -, -(CH 2) 2 -, -(CH 2) 3 -, -(CH 2) 4 -, -(CH 2) 5 - and -(CH 2) 6 -; Z 1 and Z 2 are each independently selected from CR 1 and N; Z 3 and Z 4 are each independently selected from CR and N, wherein R is H, alkyl or substituted alkyl; each R 1 is independently selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycle and substituted heterocycle; R 2 and R 5 are each independently selected from H, OH, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, -OCF 3, halogen, amine, substituted amine, amide, heterocycle and substituted heterocycle; R 3 and R 4 are each independently selected from H, OH, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, -OCF 3, halogen, amine, substituted amine, amide, heterocycle and substituted heterocycle; or R 3 and R 4 together with the carbon atoms to which they are attached form a fused ring selected from heterocycle, substituted heterocycle, cycloalkyl, substituted cycloalkyl, aryl and substituted aryl; or a pharmaceutically acceptable salt or a solvate thereof.
A target detection method, comprising: determining first images from a plurality of images, wherein a candidate target is contained in the first images, wherein the plurality of images comprise continuous images of a time sequence; acquiring confidence degrees of the candidate target in respective first images; calculating an appearance probability of the candidate target according to weights of the respective first images and the confidence degrees, wherein a weight of each first image is set according to at least one of proximity of the first image to current time and a number of candidate targets detected in the first image, wherein the calculating the appearance probability of the candidate target comprises: performing respective multiplications on the weights of the respective first images with the confidence degrees of the candidate target in corresponding first images, to obtain first appearance probabilities of the candidate target in the respective first images; and adding the first appearance probabilities of the candidate target in the respective first images, to obtain the appearance probability of the candidate target; and determining the candidate target with the appearance probability meeting a first preset condition, as a final target. determining first images from a plurality of images, wherein a candidate target is contained in the first images, wherein the plurality of images comprise continuous images of a time sequence; acquiring confidence degrees of the candidate target in respective first images; calculating an appearance probability of the candidate target according to weights of the respective first images and the confidence degrees, wherein a weight of each first image is set according to at least one of proximity of the first image to current time and a number of candidate targets detected in the first image, wherein the calculating the appearance probability of the candidate target comprises: performing respective multiplications on the weights of the respective first images with the confidence degrees of the candidate target in corresponding first images, to obtain first appearance probabilities of the candidate target in the respective first images; and adding the first appearance probabilities of the candidate target in the respective first images, to obtain the appearance probability of the candidate target; and performing respective multiplications on the weights of the respective first images with the confidence degrees of the candidate target in corresponding first images, to obtain first appearance probabilities of the candidate target in the respective first images; and adding the first appearance probabilities of the candidate target in the respective first images, to obtain the appearance probability of the candidate target; and determining the candidate target with the appearance probability meeting a first preset condition, as a final target.
An endoilluminator system, comprising: an endoilluminator probe comprising a nano-scale optical fiber having an outer diameter of 100 μm or less and a probe fiber connector; an illumination source comprising a source fiber connector, the illumination source configured to produce an illumination spot at the source fiber connector, the illumination spot having a diameter smaller than a diameter of a fiber core of the nano-scale optical fiber, characterized in that the illumination spot has a diameter of about 1 μm, the probe fiber connector and the source connector being adapted to be connected to align the illumination spot off-center relative to the fiber core of the nano-scale optical fiber such that the angular distribution of light emitted by the nano-scale optical fiber is increased relative to aligning the illumination spot at a center of the nano-scale optical fiber. an endoilluminator probe comprising a nano-scale optical fiber having an outer diameter of 100 μm or less and a probe fiber connector; an illumination source comprising a source fiber connector, the illumination source configured to produce an illumination spot at the source fiber connector, the illumination spot having a diameter smaller than a diameter of a fiber core of the nano-scale optical fiber, characterized in that the illumination spot has a diameter of about 1 μm, the probe fiber connector and the source connector being adapted to be connected to align the illumination spot off-center relative to the fiber core of the nano-scale optical fiber such that the angular distribution of light emitted by the nano-scale optical fiber is increased relative to aligning the illumination spot at a center of the nano-scale optical fiber.
A grinding tool for grinding an engine block, including - a main body including a central coupling region for connecting the main body to a rotary drive of a grinding machine, wherein the main body is of a substantially rotationally symmetrical configuration with respect to an axis of rotation, - a grinding layer which is arranged on the main body and extends at least over an outer circular ring zone of the main body, - at least one feed for a cooling fluid, and - a substantially circular cover plate which is arranged substantially normal to the axis of rotation and forming an axial gap on the main body, wherein the axial gap is in fluid communication with the at least one feed and the grinding layer so that a cooling fluid fed by way of the at least one feed can be passed by way of the axial gap to the grinding layer, wherein first passages for specifically passing the cooling fluid from the at least one feed to the grinding layer are arranged at a surface of the main body, that faces towards the cover plate, and/or at a surface of the cover plate, that faces towards the main body, characterised in that the main body and the cover plate have an inclined surface (17, 18) which adjoins the grinding layer, wherein the inclined surfaces (17, 18) are in region-wise contact with each other, and that second passages for specifically guiding the cooling fluid are arranged at the inclined surface, and that the second passages are arranged displaced in relation to the first passages and/or there are provided more second passages than first passages. - a main body including a central coupling region for connecting the main body to a rotary drive of a grinding machine, wherein the main body is of a substantially rotationally symmetrical configuration with respect to an axis of rotation, - a grinding layer which is arranged on the main body and extends at least over an outer circular ring zone of the main body, - at least one feed for a cooling fluid, and - a substantially circular cover plate which is arranged substantially normal to the axis of rotation and forming an axial gap on the main body, wherein the axial gap is in fluid communication with the at least one feed and the grinding layer so that a cooling fluid fed by way of the at least one feed can be passed by way of the axial gap to the grinding layer, wherein first passages for specifically passing the cooling fluid from the at least one feed to the grinding layer are arranged at a surface of the main body, that faces towards the cover plate, and/or at a surface of the cover plate, that faces towards the main body, characterised in that the main body and the cover plate have an inclined surface (17, 18) which adjoins the grinding layer, wherein the inclined surfaces (17, 18) are in region-wise contact with each other, and that second passages for specifically guiding the cooling fluid are arranged at the inclined surface, and that the second passages are arranged displaced in relation to the first passages and/or there are provided more second passages than first passages.
An ex-vivo method for targeted integration into purified hematopoietic stem cells and/or progenitor cells, said method comprising the following steps: (a) delivering a non-integrating lentiviral (IDLV) donor nucleic acid to the HSC and/or PC cells; (b) culturing the cells obtained by step (a) prior to: (c) delivering at least one zinc finger nuclease to the cells obtained by step (b) such that the donor nucleic acid is integrated into the genome. (a) delivering a non-integrating lentiviral (IDLV) donor nucleic acid to the HSC and/or PC cells; (b) culturing the cells obtained by step (a) prior to: (c) delivering at least one zinc finger nuclease to the cells obtained by step (b) such that the donor nucleic acid is integrated into the genome.
A cutting tool for use within a surgical handpiece, the handpiece including a drive shaft, the cutting tool comprising: an outer tubular member including a first magnet; and an inner tubular member including a second magnet, the inner tubular member slidably disposed within the outer tubular member, wherein a force is created between the first magnet and the second magnet when the inner tubular member is slidably disposed within the outer tubular member, and wherein the force creates a preload force between the inner tubular member and the outer tubular member. an outer tubular member including a first magnet; and an inner tubular member including a second magnet, the inner tubular member slidably disposed within the outer tubular member, wherein a force is created between the first magnet and the second magnet when the inner tubular member is slidably disposed within the outer tubular member, and wherein the force creates a preload force between the inner tubular member and the outer tubular member.
A domestic appliance, wherein said domestic appliance is an oven, comprising a food probe for determining of at least one parameter within an interior space of the domestic appliance, wherein the food probe is connectable to the domestic appliance by a cord, characterized in that the domestic appliance comprises a cord pullback mechanism, wherein the cord pullback mechanism is for winding and dispensing the cord, and wherein the cord pullback mechanism is positioned within a receiving, and wherein the receiving is provided in a frame structure of the domestic appliance, and wherein the frame structure is a frame structure surrounding an opening of the interior space of the domestic appliance.
A substrate detection apparatus adapted for detecting conditions of a plurality of substrates stored in a cassette, characterized in that it comprises: a collimating reflector located on one side of the plurality of substrates; illumination means configured to radiate light toward the collimating reflector such that light is collimated and such that edge portions of the substrates are located in an optical path of the collimated light; image acquiring means configured to acquire a passing light image including the edge portions of the substrates, the passing light image being formed on the collimating reflector with the collimated light, the light being radiated from the illumination means; and image processing means configured to process the passing light image obtained by the image acquiring means, thereby detecting the conditions of the substrates stored in the cassette. a collimating reflector located on one side of the plurality of substrates; illumination means configured to radiate light toward the collimating reflector such that light is collimated and such that edge portions of the substrates are located in an optical path of the collimated light; image acquiring means configured to acquire a passing light image including the edge portions of the substrates, the passing light image being formed on the collimating reflector with the collimated light, the light being radiated from the illumination means; and image processing means configured to process the passing light image obtained by the image acquiring means, thereby detecting the conditions of the substrates stored in the cassette.
An abnormality diagnosis system of an air-fuel ratio sensor comprising an exhaust purification catalyst provided in an exhaust passage (9, 19, 21, 22, 23) of an internal combustion engine, an upstream side air-fuel ratio sensor provided in said exhaust passage at an upstream side of said exhaust purification catalyst in the exhaust flow direction, a downstream side air-fuel ratio sensor provided in said exhaust passage at a downstream side of said exhaust purification catalyst in the exhaust flow direction, and a diagnosis device for diagnosing abnormality of the downstream side air-fuel ratio sensor, based on outputs of these air-fuel ratio sensors, wherein said diagnosis device judges that said downstream side air-fuel ratio sensor is normal in the case where an output air-fuel ratio of said upstream side air-fuel ratio sensor becomes a rich air-fuel ratio which is richer than the stoichiometric air-fuel ratio and when a timer counter which counts the time during which an output air-fuel ratio of said downstream side air-fuel ratio sensor becomes a rich judgment reference air-fuel ratio which is richer than a stoichiometric air-fuel ratio or less becomes a predetermined judgment value larger than zero; wherein said diagnosis device changes a count up amount of said time counter in accordance with a rich degree when an output air-fuel ratio of said downstream side air-fuel ratio sensor becomes said rich judgment reference air-fuel ratio or less.
A method for channel estimation in a FDD massive multiple-input-multiple-output (MIMO) backhaul system, the method comprising: transmitting, by a central node of the MIMO backhaul system to a small cell repeater terminal (120-1,..., 120-k,..., 120-K) on the downlink, a trigger signal; transmitting, by the central node to the small cell repeater terminal (120-1,... 120-k,..., 120-K), a downlink pilot signal carrying a set of pilot sequences that are mutually orthogonal in the frequency domain, each pilot sequence in the set of pilot sequences corresponding to an antenna of an antenna array at the central node; receiving, at the central node, an uplink pilot signal carrying the set of pilot sequences transmitted by the small cell repeater terminal on the uplink, the received uplink pilot signal being a frequency converted retransmission of the downlink pilot signal; and estimating at least one of an uplink channel and a downlink channel between the central node and the small cell repeater terminal based on the set of pilot sequences and the received uplink pilot signal. transmitting, by a central node of the MIMO backhaul system to a small cell repeater terminal (120-1,..., 120-k,..., 120-K) on the downlink, a trigger signal; transmitting, by the central node to the small cell repeater terminal (120-1,... 120-k,..., 120-K), a downlink pilot signal carrying a set of pilot sequences that are mutually orthogonal in the frequency domain, each pilot sequence in the set of pilot sequences corresponding to an antenna of an antenna array at the central node; receiving, at the central node, an uplink pilot signal carrying the set of pilot sequences transmitted by the small cell repeater terminal on the uplink, the received uplink pilot signal being a frequency converted retransmission of the downlink pilot signal; and estimating at least one of an uplink channel and a downlink channel between the central node and the small cell repeater terminal based on the set of pilot sequences and the received uplink pilot signal.
A method for Discontinuous Reception, DRX, operation in a wireless communication system comprising a user equipment, UE, and an enhanced Node B, eNB, the method comprising, while the UE and the eNB are in DRX operation in an LTE_ACTIVE state: determining, by the eNB whether the DRX needs to be adjusted; and if the DRX needs to be adjusted, performing an adjustment on the DRX by the eNB; characterized by transmitting, from the eNB to the UE, a MAC-PDU with a modified header including data identifying the adjustment on the DRX; responsive to receipt of a MAC-PDU with the modified header including data identifying the adjustment on the DRX by the UE, sending an acknowledgement to the eNB and adjusting the DRX period at the UE; and receiving the acknowledgement and starting a modified DRX period by the eNB; wherein the adjustment comprises deactivation of the DRX, and the modified header of the MAC-PDU transmitted from the eNB to the UE includes a zero value for the DRX indicating the deactivation of the DRX; or the adjustment comprises adjusting the DRX period, the modified header of the MAC-PDU transmitted from the eNB to the UE includes a value identifying a new DRX period, the modified header of the MAC-PDU transmitted from the eNB to the UE further includes data identifying an activation time for the new DRX period, and if an activation time is indicated in the MAC-PDU header, both the UE and eNB apply the new DRX value at that time. determining, by the eNB whether the DRX needs to be adjusted; and if the DRX needs to be adjusted, performing an adjustment on the DRX by the eNB; characterized by transmitting, from the eNB to the UE, a MAC-PDU with a modified header including data identifying the adjustment on the DRX; responsive to receipt of a MAC-PDU with the modified header including data identifying the adjustment on the DRX by the UE, sending an acknowledgement to the eNB and adjusting the DRX period at the UE; and receiving the acknowledgement and starting a modified DRX period by the eNB; the adjustment comprises deactivation of the DRX, and the modified header of the MAC-PDU transmitted from the eNB to the UE includes a zero value for the DRX indicating the deactivation of the DRX; or the adjustment comprises adjusting the DRX period, the modified header of the MAC-PDU transmitted from the eNB to the UE includes a value identifying a new DRX period, the modified header of the MAC-PDU transmitted from the eNB to the UE further includes data identifying an activation time for the new DRX period, and if an activation time is indicated in the MAC-PDU header, both the UE and eNB apply the new DRX value at that time.
A dose planning system for a therapeutic treatment of diseased tissue of an organ of interest comprising - a biopsy map creation module configured for receiving biopsy information for an organ of interest regarding biopsy locations and tissue characteristics of tissue found at the biopsy locations, wherein the biopsy map creation module is further configured for creating a spatially annotated biopsy map for the organ, by linking the spatial information on the biopsy locations to the tissue characteristics of tissue found at the corresponding biopsy locations and - a probability map calculation module configured for creating a tumour probability map by calculating a tumour probability for locations in the organ from which no biopsy was taken by using the tumour and/or tissue characteristics from the biopsy locations and - a dose planning module configured for creating a dose plan based on the tumour probability map, wherein planning constraints are such that for an area with an average higher tumour probability a higher planned dose is planned and for an area with an average lower tumour probability in a lower planned dose is planned. - a biopsy map creation module configured for receiving biopsy information for an organ of interest regarding biopsy locations and tissue characteristics of tissue found at the biopsy locations, wherein the biopsy map creation module is further configured for creating a spatially annotated biopsy map for the organ, by linking the spatial information on the biopsy locations to the tissue characteristics of tissue found at the corresponding biopsy locations and - a probability map calculation module configured for creating a tumour probability map by calculating a tumour probability for locations in the organ from which no biopsy was taken by using the tumour and/or tissue characteristics from the biopsy locations and - a dose planning module configured for creating a dose plan based on the tumour probability map, wherein planning constraints are such that for an area with an average higher tumour probability a higher planned dose is planned and for an area with an average lower tumour probability in a lower planned dose is planned.
A monoclonal antibody which binds to an extracellular region of human TIM-3, wherein the antibody exhibits ADCC activity and is a monoclonal antibody which comprises VH of an antibody comprising the amino acid sequence represented by amino acids 20 to 140 of SEQ ID NO: 8 and comprises VL of an antibody comprising the amino acid sequence represented by amino acids 21 to 127 of SEQ ID NO: 10.