A device for inserting a guidewire suitable for hearth valve prosthesis in a blood vessel, comprising: an outer catheter, an intermediate catheter that may be inserted into said outer catheter, an inner catheter that may be inserted in said intermediate catheter, wherein said intermediate catheter has an apical portion that defines a tube onto which an anchoring element for anchoring to inner walls of a blood vessel slides, said anchoring element comprises an annular slider slidable around said tube and a plurality of wire elements each having a proximal end fixed to said tube and a distal end fixed to said annular slider, wherein said wire elements are made of a shape memory material and are configured to bend spontaneously for displacing radially away from said tube when they exit from said outer catheter, making said annular slider slide around the tube towards said proximal ends, said wire elements being configured to be in abutment against inner walls of the blood vessel at opposite points contrasting displacements of said tube; wherein the outer catheter has a respective first handle configured to push the outer catheter forward inside a blood vessel and to make said outer catheter slide on the intermediate catheter, characterized in that the intermediate catheter has a respective second handle configured to push forward and/or pull backward said intermediate catheter in said outer catheter; the inner catheter has a respective third handle configured to push forward and/or pull backward said inner catheter in said intermediate catheter and to rotate it around a longitudinal axis, said third handle having a through hole to allow insertion of a guidewire from back, wherein when the first handle is retracted against the second handle, the anchoring element protrudes from the outer catheter; wherein at least an apical portion of said inner catheter is configured to assume a curved shape at rest, said apical portion being configured to be elastically distended when inserted in the tube of said intermediate catheter and to assume spontaneously the curved shape at rest as far as it protrudes out of the tube, so as the apical part of the inner catheter is elastically forced to remain lying when it is inside the intermediate catheter and, when the third handle is pushed towards the second handle, the apical part of the inner catheter comes out of the tube and the longer the inner catheter protrudes from the tube the more it bends so as, by pushing or retracting the third handle and by turning it on itself, an operator may adjust at will a curvature of the apical part of the inner catheter and orient in the blood vessel the apical part of the inner catheter in order to point it. an outer catheter, an intermediate catheter that may be inserted into said outer catheter, an inner catheter that may be inserted in said intermediate catheter, wherein said intermediate catheter has an apical portion that defines a tube onto which an anchoring element for anchoring to inner walls of a blood vessel slides, said anchoring element comprises an annular slider slidable around said tube and a plurality of wire elements each having a proximal end fixed to said tube and a distal end fixed to said annular slider, wherein said wire elements are made of a shape memory material and are configured to bend spontaneously for displacing radially away from said tube when they exit from said outer catheter, making said annular slider slide around the tube towards said proximal ends, said wire elements being configured to be in abutment against inner walls of the blood vessel at opposite points contrasting displacements of said tube; wherein the outer catheter has a respective first handle configured to push the outer catheter forward inside a blood vessel and to make said outer catheter slide on the intermediate catheter, the intermediate catheter has a respective second handle configured to push forward and/or pull backward said intermediate catheter in said outer catheter; the inner catheter has a respective third handle configured to push forward and/or pull backward said inner catheter in said intermediate catheter and to rotate it around a longitudinal axis, said third handle having a through hole to allow insertion of a guidewire from back, wherein when the first handle is retracted against the second handle, the anchoring element protrudes from the outer catheter; wherein at least an apical portion of said inner catheter is configured to assume a curved shape at rest, said apical portion being configured to be elastically distended when inserted in the tube of said intermediate catheter and to assume spontaneously the curved shape at rest as far as it protrudes out of the tube, so as the apical part of the inner catheter is elastically forced to remain lying when it is inside the intermediate catheter and, when the third handle is pushed towards the second handle, the apical part of the inner catheter comes out of the tube and the longer the inner catheter protrudes from the tube the more it bends so as, by pushing or retracting the third handle and by turning it on itself, an operator may adjust at will a curvature of the apical part of the inner catheter and orient in the blood vessel the apical part of the inner catheter in order to point it.