A balloon catheter, comprising: an elongated catheter shaft comprising a proximal end and a distal end, wherein the elongated catheter shaft defines a longitudinal axis extending between the proximal end and the distal end; an expandable balloon connected to the elongated catheter shaft adjacent the distal end of the elongated catheter shaft, wherein the expandable balloon comprises an outer surface; and a sheath comprising an inner surface defining a lumen and a therapeutic agent disposed within the lumen of the sheath, wherein at least a portion of the elongated catheter shaft is disposed within the lumen of the sheath; wherein the balloon catheter further comprises a first configuration and a second configuration, wherein the expandable balloon and the sheath are configured for movement relative to each other along the longitudinal axis of the elongated catheter shaft between the first configuration and the second configuration, wherein when in the first configuration the expandable balloon is disposed distally from the sheath such that the outer surface of the expandable balloon does not contact the lumen of the sheath, wherein when in the second configuration at least a portion of the outer surface of the expandable balloon is disposed within the lumen of the sheath such that it contacts the therapeutic agent, and wherein at least a portion of the therapeutic agent that contacts the outer surface of the expandable balloon is transferred from the lumen of the sheath to the outer surface of the expandable balloon when the balloon catheter is in the second configuration, and wherein the balloon catheter is configured to be advanced to a treatment site with the catheter in the first configuration. an elongated catheter shaft comprising a proximal end and a distal end, wherein the elongated catheter shaft defines a longitudinal axis extending between the proximal end and the distal end; an expandable balloon connected to the elongated catheter shaft adjacent the distal end of the elongated catheter shaft, wherein the expandable balloon comprises an outer surface; and a sheath comprising an inner surface defining a lumen and a therapeutic agent disposed within the lumen of the sheath, wherein at least a portion of the elongated catheter shaft is disposed within the lumen of the sheath; wherein the balloon catheter further comprises a first configuration and a second configuration, wherein the expandable balloon and the sheath are configured for movement relative to each other along the longitudinal axis of the elongated catheter shaft between the first configuration and the second configuration, wherein when in the first configuration the expandable balloon is disposed distally from the sheath such that the outer surface of the expandable balloon does not contact the lumen of the sheath, wherein when in the second configuration at least a portion of the outer surface of the expandable balloon is disposed within the lumen of the sheath such that it contacts the therapeutic agent, and wherein at least a portion of the therapeutic agent that contacts the outer surface of the expandable balloon is transferred from the lumen of the sheath to the outer surface of the expandable balloon when the balloon catheter is in the second configuration, and wherein the balloon catheter is configured to be advanced to a treatment site with the catheter in the first configuration.