A compound represented by Formula (I-A): or a pharmaceutically acceptable salt thereof, wherein: R is H, -F, -CI, -Br, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylene-OH or 4-7 membered monocyclic heterocyclyl optionally substituted with 1-3 groups selected from -F, -CI, -Br, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, or -(C 1 -C 4)alkoxy; R 1 is -NR a R b or -OR a1; R a for each occurrence is independently -H, -(C 1 -C 6)alkyl, -(CH 2) n -(C 3 -C 7)cycloalkyl, -(CH 2) n -3-7 membered monocyclic heterocyclyl, -(CH 2) n -bridged (C 6 -C 12)cycloalkyl, optionally substituted -(CH 2) n -5-10 membered heteroaryl; or -(CH 2) n -6-12 membered bridged heterocyclyl, wherein -(C 1 -C 6)alkyl, -(CH 2) n -(C 3 -C 7)cycloalkyl, - (CH 2) n -3-7 membered monocyclic heterocyclyl, -(CH 2) n -bridged (C 6 -C 12)cycloalkyl, - (CH 2) n -5-10 membered heteroaryl, or -(CH 2) n -6-12 membered bridged heterocyclyl, is optionally substituted with 1-3 groups selected from -F, -CI, -Br, -CN, -NH 2, -OH, oxo, - (C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)haloalkoxy, -(C 1 -C 4)alkylene-OH, or -(C 1 -C 4)alkylene-NH 2; R b for each occurrence is independently -H or -(C 1 -C 6)alkyl; or R a and R b, together with the nitrogen to which they are attached, form -(C 3 -C 10)heterocyclyl; R a1 for each occurrence is independently -H, (C 1 -C 6)alkyl, (C 3 -C 10)cycloalkyl, 3-10 membered heterocyclyl, (C 6 -C 10)aryl, or 3-10 membered heteroaryl; R 4 and R 5, together with the nitrogen to which they are attached, form 4-7 membered monocyclic heterocyclyl or 6-12 membered bridged heterocyclyl, wherein the 4-7 membered monocyclic heterocyclyl or 6-12 membered bridged heterocyclyl is optionally substituted with 1-3 groups selected from -F, -CI, -Br, -CN, -NH 2, -OH, oxo, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)haloalkoxy, -(C 1 -C 4)alkylene-OH, or -(C 1 -C 4)alkylene-NH 2; R 6 for each occurrence is independently -F, -CI, -Br, -CN, -NH 2, -OH, -(C 1 -C 6)alkyl, -(C 1 -C 6)haloalkyl, -(C 2 -C 3)alkenyl, -(C 2 -C 6)alkynyl, (C 3 -C 3)cycloalkyl, -(C 1 -C 6)alkoxy, -(C 1 -C 6)haloalkoxy, -(C 1 -C 6)alkylene-OH, or -(C 1 -C 6)alkylene-NH 2; m is 0, 1, 2, or 3; and n is 0, 1, or 2. R is H, -F, -CI, -Br, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylene-OH or 4-7 membered monocyclic heterocyclyl optionally substituted with 1-3 groups selected from -F, -CI, -Br, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, or -(C 1 -C 4)alkoxy; R 1 is -NR a R b or -OR a1; R a for each occurrence is independently -H, -(C 1 -C 6)alkyl, -(CH 2) n -(C 3 -C 7)cycloalkyl, -(CH 2) n -3-7 membered monocyclic heterocyclyl, -(CH 2) n -bridged (C 6 -C 12)cycloalkyl, optionally substituted -(CH 2) n -5-10 membered heteroaryl; or -(CH 2) n -6-12 membered bridged heterocyclyl, wherein -(C 1 -C 6)alkyl, -(CH 2) n -(C 3 -C 7)cycloalkyl, - (CH 2) n -3-7 membered monocyclic heterocyclyl, -(CH 2) n -bridged (C 6 -C 12)cycloalkyl, - (CH 2) n -5-10 membered heteroaryl, or -(CH 2) n -6-12 membered bridged heterocyclyl, is optionally substituted with 1-3 groups selected from -F, -CI, -Br, -CN, -NH 2, -OH, oxo, - (C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)haloalkoxy, -(C 1 -C 4)alkylene-OH, or -(C 1 -C 4)alkylene-NH 2; R b for each occurrence is independently -H or -(C 1 -C 6)alkyl; or R a and R b, together with the nitrogen to which they are attached, form -(C 3 -C 10)heterocyclyl; R a1 for each occurrence is independently -H, (C 1 -C 6)alkyl, (C 3 -C 10)cycloalkyl, 3-10 membered heterocyclyl, (C 6 -C 10)aryl, or 3-10 membered heteroaryl; R 4 and R 5, together with the nitrogen to which they are attached, form 4-7 membered monocyclic heterocyclyl or 6-12 membered bridged heterocyclyl, wherein the 4-7 membered monocyclic heterocyclyl or 6-12 membered bridged heterocyclyl is optionally substituted with 1-3 groups selected from -F, -CI, -Br, -CN, -NH 2, -OH, oxo, -(C 1 -C 4)alkyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)alkoxy, -(C 1 -C 4)haloalkoxy, -(C 1 -C 4)alkylene-OH, or -(C 1 -C 4)alkylene-NH 2; R 6 for each occurrence is independently -F, -CI, -Br, -CN, -NH 2, -OH, -(C 1 -C 6)alkyl, -(C 1 -C 6)haloalkyl, -(C 2 -C 3)alkenyl, -(C 2 -C 6)alkynyl, (C 3 -C 3)cycloalkyl, -(C 1 -C 6)alkoxy, -(C 1 -C 6)haloalkoxy, -(C 1 -C 6)alkylene-OH, or -(C 1 -C 6)alkylene-NH 2; m is 0, 1, 2, or 3; and n is 0, 1, or 2.