mhurhangee/ep-ind-claims huggingface dataset:
An anti-NRlO antibody which has a neutralizing activity, wherein the anti-NR10 antibody is any one of: an antibody comprising a heavy chain variable region which comprises CDR1 comprising the amino acid sequence of SEQ ID NO: 1, CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and CDR3 comprising the amino acid sequence of SEQ ID NO: 3, and comprising a light chain variable region which comprises CDR1 comprising the amino acid sequence of SEQ ID NO: 5, CDR2 comprising the amino acid sequence of SEQ ID NO: 6, and CDR3 comprising the amino acid sequence of SEQ ID NO: 7; an antibody comprising the heavy chain variable region of SEQ ID NO: 4 and comprising the light chain variable region of SEQ ID NO: 8; and an antibody which binds to the same epitope as an epitope bound by the antibody of or, and competes with the antibody of or for binding to NR10. an antibody comprising a heavy chain variable region which comprises CDR1 comprising the amino acid sequence of SEQ ID NO: 1, CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and CDR3 comprising the amino acid sequence of SEQ ID NO: 3, and comprising a light chain variable region which comprises CDR1 comprising the amino acid sequence of SEQ ID NO: 5, CDR2 comprising the amino acid sequence of SEQ ID NO: 6, and CDR3 comprising the amino acid sequence of SEQ ID NO: 7; an antibody comprising the heavy chain variable region of SEQ ID NO: 4 and comprising the light chain variable region of SEQ ID NO: 8; and an antibody which binds to the same epitope as an epitope bound by the antibody of or, and competes with the antibody of or for binding to NR10.
A method comprising: at a first electronic device with one or more processors, a communication interface, and memory, wherein the first electronic device is in communication with a display: receiving a first input corresponding to an affordance to start a task in an application executing on the one or more processors; in response to receiving the first input, starting the task; while the task is ongoing, recording visual output of the application as application task data; after the task has ceased, causing to be displayed on the display a first affordance for sharing the application task data; while the first affordance is displayed, receiving a second input corresponding to selection of the first affordance; in response to receiving the second input, displaying at least one affordance configured to, when selected via user input, share the application task data with devices within a close proximity to the first electronic device, wherein the close proximity is a distance that enables the first electronic device to connect to the respective devices via short-range communications, wherein the devices include a second electronic device, and wherein the at least one affordance includes a second affordance corresponding to the second electronic device; while the second affordance is displayed, receiving third input including input corresponding to selection of the second affordance; and in response to receiving the third input, transmitting the application task data to the second electronic device over the communication interface. receiving a first input corresponding to an affordance to start a task in an application executing on the one or more processors; in response to receiving the first input, starting the task; while the task is ongoing, recording visual output of the application as application task data; after the task has ceased, causing to be displayed on the display a first affordance for sharing the application task data; while the first affordance is displayed, receiving a second input corresponding to selection of the first affordance; in response to receiving the second input, displaying at least one affordance configured to, when selected via user input, share the application task data with devices within a close proximity to the first electronic device, wherein the close proximity is a distance that enables the first electronic device to connect to the respective devices via short-range communications, wherein the devices include a second electronic device, and wherein the at least one affordance includes a second affordance corresponding to the second electronic device; while the second affordance is displayed, receiving third input including input corresponding to selection of the second affordance; and in response to receiving the third input, transmitting the application task data to the second electronic device over the communication interface.
A vehicle independent wheel suspension for a rear wheel, which can be at least minimally steered by an actuator, of a double-track vehicle, the wheel carrier of which is guided by a longitudinal control arm which extends substantially, in the longitudinal direction of the vehicle and by two transverse non-intersecting control arms (4, 5) which extend at least approximately in the transverse direction of the vehicle and are located in different planes when observed in the vehicle longitudinal direction, the ends of which, remote from the wheel carrier are directly or indirectly connected in an articulated manner to the vehicle body, while the other end of each transverse control arm is attached to the wheel carrier by a bolt or the like via a rubber bearing or by a joint which has at least a small rotational degree of freedom, characterised in that the longitudinal control arm is also directly connected to the wheel carrier by means of the same two mentioned bolts or the like, in each case via a rubber bearing or a joint which has at least a small rotational degree of freedom, such that the wheel carrier is at least slightly swivellable, relative to the longitudinal control arm, about a swivel axis which runs substantially in a vertical direction and is formed by these rubber bearings or joints, this rotational degree of freedom, formed in this way, of the wheel carrier being bound by a tie rod element which is connected to the wheel carrier and is at least partly displaceable in the transverse direction of the vehicle by the actuator.
A motor stator structure comprising multiple teeth, the teeth being uniformly annularly distributed and radially outwardly extending, each of the teeth having a tooth root, the tooth roots of two adjacent teeth being arranged at intervals; and multiple arched bridge sections (30, 30'), each of the arched bridge sections (30, 30') being bridged between the tooth roots of two adjacent teeth, wherein each arched bridge section (30, 30') has an arched section (31, 31'), wherein each arched bridge section (30, 30') has a notch, the notch being formed on one side of the arched section (31, 31') with its opening directed to a center of the motor stator structure, characterized in that the arched section (31, 31') extends along a predetermined shape, wherein the predetermined shape is a parallelogram, an ellipse or a polygon or the arched section (31, 31') extends along a waved shape, and wherein the opening of the notch has an inner diameter smaller than an inner diameter of a main portion of the notch.
An ex vivo method of making a modified hematopoietic cell comprising: a) introducing into a hematopoietic stem/progenitor cell a template nucleic acid comprising at least portion of an HLA-DRB1 *04:01 allele, including codon 71; wherein the nucleic acid sequence of codon 71 of the template nucleic acid codes for glutamic acid, and wherein the hematopoietic stem/progenitor cell comprises a genomic HLA-DRB1 *04:01 allele that codes for lysine at codon 71 that is substituted with the template nucleic acid; b) substituting at least codon 71 of the template nucleic acid for the codon 71 coding for lysine in the genomic HLA-DRB1 *04:01allele. a) introducing into a hematopoietic stem/progenitor cell a template nucleic acid comprising at least portion of an HLA-DRB1 *04:01 allele, including codon 71; wherein the nucleic acid sequence of codon 71 of the template nucleic acid codes for glutamic acid, and wherein the hematopoietic stem/progenitor cell comprises a genomic HLA-DRB1 *04:01 allele that codes for lysine at codon 71 that is substituted with the template nucleic acid; b) substituting at least codon 71 of the template nucleic acid for the codon 71 coding for lysine in the genomic HLA-DRB1 *04:01allele.
A method for direct bonding between a first substrate and a second substrate, used in particular in the microelectronics industry, the method comprising the steps of: a) Providing the first substrate and the second substrate, b) Forming a tungsten oxide based first bonding layer over the first substrate and a tungsten oxide based second bonding layer over the second substrate, at least one among the first bonding layer and the second bonding layer including, a third element M so as to form MWxOy type alloy, the atomic content of M in the composition of the alloy being comprised between 0.5 and 20% and preferably comprised between 1 and 10%, c) Proceeding with the direct bonding between the first bonding layer and the second bonding layer, and d) Carrying out a heat treatment at a temperature higher than 250°C. a) Providing the first substrate and the second substrate, b) Forming a tungsten oxide based first bonding layer over the first substrate and a tungsten oxide based second bonding layer over the second substrate, at least one among the first bonding layer and the second bonding layer including, a third element M so as to form MWxOy type alloy, the atomic content of M in the composition of the alloy being comprised between 0.5 and 20% and preferably comprised between 1 and 10%, c) Proceeding with the direct bonding between the first bonding layer and the second bonding layer, and d) Carrying out a heat treatment at a temperature higher than 250°C.
A surgical tool system for drilling holes in an acetabulum to accommodate screws used to fasten an acetabular cup to the acetabulum, the acetabular cup comprising a concave portion, cup slots disposed in the concave portion in close proximity to a circumferential edge of the acetabular cup and one or more through holes to accommodate screws for fastening the acetabular cup to the acetabulum, the surgical tool system comprising: a drill guide sized to fit within the concave portion and having spring-loaded pins arranged to engage the cup slots when the drill guide is optimally positioned within the acetabular cup, the drill guide further comprising one or more through holes sized and spaced to line up approximately concentrically with the through holes of the acetabular cup and a guide indent for each through hole of the drill guide, each guide indent being positioned on a beam member which traverses the drill guide at a circumferential edge thereof; a handle comprising a shaft with a drill bit guide disposed at the distal end thereof, the drill bit guide having a drill bit guide distal end and a side portion, the drill bit guide being sized to engage a through hole of the drill guide and the side portion being positioned to engage the guide indent for its respective through hole of the drill guide; and a drill bit having a cutting portion and a shaft sized to pass through the drill bit guide. a drill guide sized to fit within the concave portion and having spring-loaded pins arranged to engage the cup slots when the drill guide is optimally positioned within the acetabular cup, the drill guide further comprising one or more through holes sized and spaced to line up approximately concentrically with the through holes of the acetabular cup and a guide indent for each through hole of the drill guide, each guide indent being positioned on a beam member which traverses the drill guide at a circumferential edge thereof; a handle comprising a shaft with a drill bit guide disposed at the distal end thereof, the drill bit guide having a drill bit guide distal end and a side portion, the drill bit guide being sized to engage a through hole of the drill guide and the side portion being positioned to engage the guide indent for its respective through hole of the drill guide; and a drill bit having a cutting portion and a shaft sized to pass through the drill bit guide.
An air-bag formed from a fabric which is formed from interwoven warp and weft yarns (1, 4; 5) which are arranged to be substantially perpendicular to one another, wherein the warp yarns (1, 4) are formed from multiple filaments which are twisted together to form the warp yarns (1, 4), with a degree of twist of about 40 turns per metre, characterised in that the weft yarns are substantially untwisted, and wherein the degree of twist of the weft yarns is less than about 5 turns per metre.
Axial impeller for conveying fluids, said impeller defining a rotation axis and comprising a hub for the connection of the impeller to a rotary shaft and a plurality of identically-shaped blades connected to the hub with constant angular pitch, wherein the radius of an outer circumference circumscribing the impeller and tangent to the radially outermost points of the blades defines an outer radius of the impeller, wherein the radius of an inner circumference circumscribing the hub and tangent to the connection points between the hub and the blades defines an inner radius of the impeller, wherein the radius of an intermediate circumference at a blade section with extreme angle of incidence defines an intermediate radius of the impeller, said intermediate radius being greater than the inner radius and less than the outer radius, wherein the blades have a profile edge made up of a radially outer apical edge, a leading edge that is the first to meet the flow, a trailing edge opposite the leading edge and joining edges in the connection area of the blade with the hub, wherein, when seen in a projection on a plane normal to the rotation axis: - the leading edge is substantially rectilinear and extends in a direction radial to the rotation axis, - the apical edge is shaped like an arc of circle concentric to the rotation axis, - the trailing edge has a curved and concave shape with a wrap angle that increases from the intermediate radius up to close to the outer radius, - the joining edge extends continuously and stepless from the trailing edge of a blade to the leading edge of the adjacent blade, characterized in that the joining edge has, when seen in a projection on a plane normal to the rotation axis, an arc of circle shape having an angular extension of between 160° and 180° and a radius of between 0.12*R1 and 0.18*R1, in which R1 is the outer radius of the impeller. - the leading edge is substantially rectilinear and extends in a direction radial to the rotation axis, - the apical edge is shaped like an arc of circle concentric to the rotation axis, - the trailing edge has a curved and concave shape with a wrap angle that increases from the intermediate radius up to close to the outer radius, - the joining edge extends continuously and stepless from the trailing edge of a blade to the leading edge of the adjacent blade, characterized in that the joining edge has, when seen in a projection on a plane normal to the rotation axis, an arc of circle shape having an angular extension of between 160° and 180° and a radius of between 0.12*R1 and 0.18*R1, in which R1 is the outer radius of the impeller.
A network comprising: a switch in a second network domain configured to switch traffic between a plurality of external interfaces in a first network domain via a plurality of virtual interfaces of said switch which are associated with the external interfaces in the first network domain, wherein the traffic comprises a plurality of external virtual local area network, VLAN, identifiers, VIDs, associated with the external interfaces, and said switch identifies and selects the virtual interfaces based on the external VID to send the traffic, and wherein the virtual interfaces are configured to forward traffic based on an internal VID that is assigned to the traffic independent of the external VID. a switch in a second network domain configured to switch traffic between a plurality of external interfaces in a first network domain via a plurality of virtual interfaces of said switch which are associated with the external interfaces in the first network domain, wherein the traffic comprises a plurality of external virtual local area network, VLAN, identifiers, VIDs, associated with the external interfaces, and said switch identifies and selects the virtual interfaces based on the external VID to send the traffic, and wherein the virtual interfaces are configured to forward traffic based on an internal VID that is assigned to the traffic independent of the external VID.
A vehicle comprising: a transmission drive pulley; an engine having a combustion chamber, the engine being adapted to drive the transmission drive pulley; a driven pulley coupled to the drive pulley; a rear wheel rotated by the driven pulley; a cooling fan provided on the drive pulley and positioned outwardly of the drive pulley in a vehicle width direction; a transmission cover adapted to cover the drive pulley and cooling fan, wherein the transmission cover includes an intake port provided outwardly of the cooling fan in the vehicle width direction, and an exhaust port through which air sucked from the intake port is exhausted; and characterized by an intake duct provided in a longitudinal direction of the vehicle and comprising a first intake duct portion, through which air is sucked, and a second intake duct portion connected to the intake port, wherein the second intake duct portion comprises a portion bent inward in the vehicle width direction to be connected to the first duct portion, and an outer side of the first intake duct portion in the vehicle width direction is provided inwardly of an outer side of the cooling fan in the vehicle width direction. a transmission drive pulley; an engine having a combustion chamber, the engine being adapted to drive the transmission drive pulley; a driven pulley coupled to the drive pulley; a rear wheel rotated by the driven pulley; a cooling fan provided on the drive pulley and positioned outwardly of the drive pulley in a vehicle width direction; a transmission cover adapted to cover the drive pulley and cooling fan, wherein the transmission cover includes an intake port provided outwardly of the cooling fan in the vehicle width direction, and an exhaust port through which air sucked from the intake port is exhausted; and characterized by an intake duct provided in a longitudinal direction of the vehicle and comprising a first intake duct portion, through which air is sucked, and a second intake duct portion connected to the intake port, wherein the second intake duct portion comprises a portion bent inward in the vehicle width direction to be connected to the first duct portion, and an outer side of the first intake duct portion in the vehicle width direction is provided inwardly of an outer side of the cooling fan in the vehicle width direction.
A press hardening method comprising the following steps: A. the provision of a steel sheet for heat-treatment as described in the European Standard EN 10083, precoated with a zinc- or aluminum-based pre-coating, B. the deposition of a hydrogen barrier pre-coating over a thickness from 10 to 550 nm and consisting of nickel and chromium; or nickel and aluminum; or magnesium; or chromium; or nickel, aluminum and and optionally Sr, Sb, Pb, Ti, Ca, Mn, Sn, La, Ce, Cr, Zr or Bi, the content by weight of each additional element being inferior to 0.3% by weight, C. the batch annealing of the precoated steel sheet to obtain a pre-alloyed steel sheet, the cooling after the batch annealing being performed at a speed of 29.0 °C.h -1 or less, performed at a temperature of at least 450°C during at least 1h, D. the cutting of the pre-alloyed steel sheet to obtain blank, E. the thermal treatment of the blank at a temperature between 800 and 970°C during a dwell time between 1 and 12 minutes to obtain a fully austenitic microstructure in the steel, F. the transfer of the blank into a press tool, G. the hot-forming of the blank at a temperature between 600 to 830°C to obtain a part, H. the cooling of the part obtained at step G) in order to obtain a microstructure in steel being mostly martensitic. A. the provision of a steel sheet for heat-treatment as described in the European Standard EN 10083, precoated with a zinc- or aluminum-based pre-coating, B. the deposition of a hydrogen barrier pre-coating over a thickness from 10 to 550 nm and consisting of nickel and chromium; or nickel and aluminum; or magnesium; or chromium; or nickel, aluminum and and optionally Sr, Sb, Pb, Ti, Ca, Mn, Sn, La, Ce, Cr, Zr or Bi, the content by weight of each additional element being inferior to 0.3% by weight, C. the batch annealing of the precoated steel sheet to obtain a pre-alloyed steel sheet, the cooling after the batch annealing being performed at a speed of 29.0 °C.h -1 or less, performed at a temperature of at least 450°C during at least 1h, D. the cutting of the pre-alloyed steel sheet to obtain blank, E. the thermal treatment of the blank at a temperature between 800 and 970°C during a dwell time between 1 and 12 minutes to obtain a fully austenitic microstructure in the steel, F. the transfer of the blank into a press tool, G. the hot-forming of the blank at a temperature between 600 to 830°C to obtain a part, H. the cooling of the part obtained at step G) in order to obtain a microstructure in steel being mostly martensitic.
A pharmaceutical composition for use in blocking a hyaluronan in a serum of a subject to prevent an inflammation thereof or treating the subject suffering from an infection with a dengue virus, wherein the subject was identified to suffer from a dengue virus infection, the pharmaceutical composition characterized by comprising: a component being one selected from the group consisting of a first pharmaceutically effective amount of a 4-methyl umbelliferone sodium salt, a second pharmaceutically effective amount of a CD44 small interfering RNA (siRNA), a third pharmaceutically effective amount of an anti-CD44 antibody, a fourth pharmaceutically effective amount of a hyaluronidase and a combination thereof.
A tool for implanting an inflatable penile cylinder, the tool comprising: a pincher connected to a handle, the handle operable to open the pincher a distance to receive the inflatable penile cylinder and operable to close the pincher against opposed sides of the inflatable penile cylinder; a suction feature provided on the pincher, the suction feature operable to couple the inflatable penile cylinder to the pincher; and an evacuation feature provided on the handle, the evacuation feature operable to provide suction to the suction feature, characterized in that the pincher includes a first pinch surface located on a proximal portion of a first blade of the tool and an opposed second pinch surface located on a proximal portion of a second blade of the tool, with the first blade connected to a first handle portion of the handle and the second blade connected to a second handle portion of the handle. a pincher connected to a handle, the handle operable to open the pincher a distance to receive the inflatable penile cylinder and operable to close the pincher against opposed sides of the inflatable penile cylinder; a suction feature provided on the pincher, the suction feature operable to couple the inflatable penile cylinder to the pincher; and an evacuation feature provided on the handle, the evacuation feature operable to provide suction to the suction feature, characterized in that the pincher includes a first pinch surface located on a proximal portion of a first blade of the tool and an opposed second pinch surface located on a proximal portion of a second blade of the tool, with the first blade connected to a first handle portion of the handle and the second blade connected to a second handle portion of the handle.