A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein, L 1 is selected from the group consisting of C, C(R 1)(R 2), substituted or unsubstituted -C 2-6 alkylene-, and substituted or unsubstituted -C 3-6 cycloalkylene-; Z is selected from the group consisting of halo, CN, OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-3 haloalkyl, C 1-3 haloalkoxy, amino, C 1-3 alkylamino, di(C 1-3 alkyl)amino, substituted or unsubstituted C 3-6 cycloalkyl, substituted or unsubstituted C 4-6 heterocycloalkyl, substituted or unsubstituted heteroaryl, and a group of Formula (Z-1): or L 1 is absent and Z is selected from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and substituted or unsubstituted heteroaryl; R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, COOR 1A, -CONR 1A R 1B, or are optionally joined together to form a substituted or unsubstituted cycloalkyl; R 3 is hydrogen, halogen, -CF 3, -CN, -OR 3A, -NR 3A R 3B, -COOR 3A, -CONR 3A R 3B, -, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 4 is hydrogen, halogen, -CF 3, -CN, -OR 4A, -NR 4A R 4B, -COOR 4A, - CONR 4A R 4B,, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or R 3 and R 4 are optionally joined together to form a substituted or unsubstituted cycloalkyl; R 5 is independently hydrogen, halogen, -CF 3, -CN, -OR 5A, -NR 5A R 5B, -COOR 5A,-CONR 5A R 5B, -SR 5A, -OCF 3, -OCHF 2, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; R 6 and R 7 are independently substituted or unsubstituted C 1 -C 5 alkyl; R 1A, R 1B, R 3A, R 3B, R 4A, R 4B, R 5A, and R 5B are independently hydrogen, -OH, -NH 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or R 1A and R 1B, R 3a and R 3B, R 4A and R 4B, or R 5A and R 5B are independently optionally joined together to independently form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; R 8 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl; and z1 is an integer of 0, 1, 2, 3, 4, or 5. L 1 is selected from the group consisting of C, C(R 1)(R 2), substituted or unsubstituted -C 2-6 alkylene-, and substituted or unsubstituted -C 3-6 cycloalkylene-; Z is selected from the group consisting of halo, CN, OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-3 haloalkyl, C 1-3 haloalkoxy, amino, C 1-3 alkylamino, di(C 1-3 alkyl)amino, substituted or unsubstituted C 3-6 cycloalkyl, substituted or unsubstituted C 4-6 heterocycloalkyl, substituted or unsubstituted heteroaryl, and a group of Formula (Z-1): or L 1 is absent and Z is selected from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and substituted or unsubstituted heteroaryl; R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, COOR 1A, -CONR 1A R 1B, or are optionally joined together to form a substituted or unsubstituted cycloalkyl; R 3 is hydrogen, halogen, -CF 3, -CN, -OR 3A, -NR 3A R 3B, -COOR 3A, -CONR 3A R 3B, -, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 4 is hydrogen, halogen, -CF 3, -CN, -OR 4A, -NR 4A R 4B, -COOR 4A, - CONR 4A R 4B,, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or R 3 and R 4 are optionally joined together to form a substituted or unsubstituted cycloalkyl; R 5 is independently hydrogen, halogen, -CF 3, -CN, -OR 5A, -NR 5A R 5B, -COOR 5A,-CONR 5A R 5B, -SR 5A, -OCF 3, -OCHF 2, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; R 6 and R 7 are independently substituted or unsubstituted C 1 -C 5 alkyl; R 1A, R 1B, R 3A, R 3B, R 4A, R 4B, R 5A, and R 5B are independently hydrogen, -OH, -NH 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or R 1A and R 1B, R 3a and R 3B, R 4A and R 4B, or R 5A and R 5B are independently optionally joined together to independently form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; R 8 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl; and z1 is an integer of 0, 1, 2, 3, 4, or 5.