A method for improving the reliability of a non-invasive diagnostic test of the presence and/or the severity of a liver disease, said method comprising: a. collecting a diagnostic index, called Initial Index, involving the mathematical combination of at least two data, wherein the Initial Index is selected from blood tests comprising ELF, FibroSpect, APRI, FIB-4, Hepascore, Fibrotest, tests from the FibroMeter family, and tests derived from the FibroMeter Family where urea was deleted from the markers; b. analyzing the reliability of each of the data combined to collect the Initial Index by identifying if at least one data of the Initial Index collected in step a) is an abnormal data, an inconsistent data, or a non-homogeneous data, or is responsible for a greater decrease in the Dispersion Index than that observed with other data: i. with comparison of each data to the expected data in a reference population, or ii. in view of intrinsic or extrinsic reliability predictor(s), or iii. by calculating the Dispersion Index of the Initial Index collected in step a), a high Dispersion Index meaning homogeneous data of the Initial Index, and performing a series of calculations of Dispersion Index of the Initial Index comprising n data where 1 to (n-2) data of the Initial Index are deleted, resulting in ranking the data lowering the most the Dispersion Index; c. if a data is an abnormal, inconsistent or a non-homogeneous data, or a data lowering a Dispersion Index, generating an Event Alert; d. if an Event Alert is generated, calculating new indexes, where the abnormal, inconsistent and/or non-homogeneous data, or a data responsible for the lowest Dispersion Index, is suppressed thereby obtaining an Alternative Index, or where the abnormal, inconsistent and/or non-homogeneous data is substituted by its mean value thereby obtaining an Estimated Index or, if at least two data are abnormal, inconsistent or non-homogeneous, the most discordant is suppressed and the other(s) is/are substituted by its/their mean value thereby obtaining a Mixed Index; e. replacing the Initial Index comprising an abnormal, inconsistent and/or a non-homogeneous data or a data affecting the Dispersion Index, with an Alternative Index, an Estimated Index, or a Mixed Index. a. collecting a diagnostic index, called Initial Index, involving the mathematical combination of at least two data, wherein the Initial Index is selected from blood tests comprising ELF, FibroSpect, APRI, FIB-4, Hepascore, Fibrotest, tests from the FibroMeter family, and tests derived from the FibroMeter Family where urea was deleted from the markers; b. analyzing the reliability of each of the data combined to collect the Initial Index by identifying if at least one data of the Initial Index collected in step a) is an abnormal data, an inconsistent data, or a non-homogeneous data, or is responsible for a greater decrease in the Dispersion Index than that observed with other data: i. with comparison of each data to the expected data in a reference population, or ii. in view of intrinsic or extrinsic reliability predictor(s), or iii. by calculating the Dispersion Index of the Initial Index collected in step a), a high Dispersion Index meaning homogeneous data of the Initial Index, and performing a series of calculations of Dispersion Index of the Initial Index comprising n data where 1 to (n-2) data of the Initial Index are deleted, resulting in ranking the data lowering the most the Dispersion Index; i. with comparison of each data to the expected data in a reference population, or ii. in view of intrinsic or extrinsic reliability predictor(s), or iii. by calculating the Dispersion Index of the Initial Index collected in step a), a high Dispersion Index meaning homogeneous data of the Initial Index, and performing a series of calculations of Dispersion Index of the Initial Index comprising n data where 1 to (n-2) data of the Initial Index are deleted, resulting in ranking the data lowering the most the Dispersion Index; c. if a data is an abnormal, inconsistent or a non-homogeneous data, or a data lowering a Dispersion Index, generating an Event Alert; d. if an Event Alert is generated, calculating new indexes, where the abnormal, inconsistent and/or non-homogeneous data, or a data responsible for the lowest Dispersion Index, is suppressed thereby obtaining an Alternative Index, or where the abnormal, inconsistent and/or non-homogeneous data is substituted by its mean value thereby obtaining an Estimated Index or, if at least two data are abnormal, inconsistent or non-homogeneous, the most discordant is suppressed and the other(s) is/are substituted by its/their mean value thereby obtaining a Mixed Index; e. replacing the Initial Index comprising an abnormal, inconsistent and/or a non-homogeneous data or a data affecting the Dispersion Index, with an Alternative Index, an Estimated Index, or a Mixed Index.