A compound having structural Formula (IIIb1) or a salt, tautomer, solvate, or ester thereof, wherein A is acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, -CN, -OR 9, -NO 2, -S C R 9, -NOR 9,-NHOR 9, -NR 9 COR 10, -NR 9 R 10, -CONR 9 R 10, -CO 2 R 9 or -NR 9 CO 2 R 10; R 17 is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl; X 1 is -CH 2 -, -O- -NR 9 -, -S-, -S - or -S 2 -; X 2 is alkylene, substituted alkylene, heteroalkylene, or substituted heteroalkylene; m is 0 or 1; c is 0, 1, or 2; Y 1 is heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, or X 3 and X 5 are independently a covalent bond, -O- or -NR 9 -; X 4 is O, NR 9, N-OR 9, or S; R x is halo, -NO 2, -CN, -OH, -NH 2, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, hetero arylalkyl or substituted heteroarylalkyl; n is 0, 1, 2, or 3; R y is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, -NR 9 R 10; and each R 9 and R 10 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; with the proviso that when X 1 is -O- or -S-, and m is zero; then X 3 is not -O-; wherein the terms alkyl, alkylene, alkanyl, alkenyl and alkynyl include cyclic radicals. A is acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, -CN, -OR 9, -NO 2, -S C R 9, -NOR 9,-NHOR 9, -NR 9 COR 10, -NR 9 R 10, -CONR 9 R 10, -CO 2 R 9 or -NR 9 CO 2 R 10; R 17 is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl; X 1 is -CH 2 -, -O- -NR 9 -, -S-, -S - or -S 2 -; X 2 is alkylene, substituted alkylene, heteroalkylene, or substituted heteroalkylene; m is 0 or 1; c is 0, 1, or 2; Y 1 is heteroaryl, substituted heteroaryl, cycloheteroalkyl, substituted cycloheteroalkyl, or X 3 and X 5 are independently a covalent bond, -O- or -NR 9 -; X 4 is O, NR 9, N-OR 9, or S; R x is halo, -NO 2, -CN, -OH, -NH 2, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, hetero arylalkyl or substituted heteroarylalkyl; n is 0, 1, 2, or 3; R y is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, -NR 9 R 10; and each R 9 and R 10 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; with the proviso that when X 1 is -O- or -S-, and m is zero; then X 3 is not -O-; wherein the terms alkyl, alkylene, alkanyl, alkenyl and alkynyl include cyclic radicals.