A compound of Formula I: and pharmaceutically acceptable salts thereof, wherein R 1 is phenyl which may be unsubstituted or substituted; R 2 is selected from: or (where N is connected to L), where U is C 0-1; R 4 is H, CH 3, halo or -CN; R 5 is H, aryl, het, alkyl containing 1-6 carbon atoms, alkoxy containing 1-6 carbon atoms, or cycloalkyl, which can be unsubstituted or substituted with one or more halo, cycloalkyl, aryl, het, and wherein at least one R 5 is not H; L is CH 2; X is N; Y is a bond; R 3 is aryl or het, which is substituted and when R 3 is het, at least one heteroring atom is N; Z is H or CH 3, and m is 0 to 3; substitutions of phenyl, aryl or het of R 1, R 2, or R 3 may be one or more of alkyl, cycloalkyl, alkoxy, cycloalkoxy, halo, -CN, oxo, aryl, carbalkoxy, OCF 3, CF 3, OH, - C N(R 6) 2, C R 6, -C OR 6, -N(R 6) 2, -NHC R 6, -SO 2 (R 6), - SO 2 N(R 6) 2; CH 2 OC N(R 6) 2, -CH 2 N(R 6) 2, -NHC OR 6, NHC N(R 6) 2, -CH 2 NHC R 6, CH 2 NHC N(R 6) 2, CH 2 NHSO 2 (R 6), CH 2 NHC OR 6 -OC R 6, NHC R 6, O-aryl, het, or O-het, in which alkyl, het, cycloalkyl, cycloalkoxy, N(R 6) 2, aryl, carbalkoxy, and alkoxy can be unsubstituted or substituted with one or more halo, -OCH 3, -OCF 3, -OH, - NH 2, alkyl, OR 6, oxo, -N 0-2 -R 6, -CN, -C N(R 6) 2, C R 6, C OR 6, -N(R 6) 2, NHC R 6, -SO 2 (R 6), - SO 2 N(R 6) 2, OSO 2 R 6, -CH 2 N(R 6) 2, -CH 2 NHC R 6, -OC R 6, aryl, NHC (R 6), O-aryl, het, O-het, or cycloalkyl; R 6 is H, alkyl, alkenyl, aryl, het, or two R 6 on one atom may form cycloalkyl, aryl, or het; and alkyl, alkenyl, aryl, het, cycloalkyl, or het may be unsubstituted or substituted by OH, oxo, alkoxy, NR 6, Nalkyl, acyl, aryl or het group; het is a 5-7 membered monocyclic heterocyclic ring which may be aromatic or non-aromatic, containing 1-4 heteroring atoms selected from N, O, and S; or an 8-12 membered fused ring system that includes at least one 5-7 membered heterocyclic ring which may be aromatic or non-aromatic, containing 1, 2, or 3 heteroring atoms selected from N, O and S, which het is unsubstituted or substituted; aryl is an aromatic radical having 6 to 14 ring carbon atoms, and no ring heteroatoms, in which said aryl group may be monocyclic or fused bicyclic or tricyclic, which may be unsubstituted or substituted by one or more substituents; and n is 0, 1, 2, or 3, or a compound selected from the group consisting of those of the structure or a pharmaceutically acceptable salt thereof. (where N is connected to L), where U is C 0-1; R 4 is H, CH 3, halo or -CN; R 5 is H, aryl, het, alkyl containing 1-6 carbon atoms, alkoxy containing 1-6 carbon atoms, or cycloalkyl, which can be unsubstituted or substituted with one or more halo, cycloalkyl, aryl, het, and wherein at least one R 5 is not H; L is CH 2; X is N; Y is a bond; R 3 is aryl or het, which is substituted and when R 3 is het, at least one heteroring atom is N; Z is H or CH 3, and m is 0 to 3; substitutions of phenyl, aryl or het of R 1, R 2, or R 3 may be one or more of alkyl, cycloalkyl, alkoxy, cycloalkoxy, halo, -CN, oxo, aryl, carbalkoxy, OCF 3, CF 3, OH, - C N(R 6) 2, C R 6, -C OR 6, -N(R 6) 2, -NHC R 6, -SO 2 (R 6), - SO 2 N(R 6) 2; CH 2 OC N(R 6) 2, -CH 2 N(R 6) 2, -NHC OR 6, NHC N(R 6) 2, -CH 2 NHC R 6, CH 2 NHC N(R 6) 2, CH 2 NHSO 2 (R 6), CH 2 NHC OR 6 -OC R 6, NHC R 6, O-aryl, het, or O-het, in which alkyl, het, cycloalkyl, cycloalkoxy, N(R 6) 2, aryl, carbalkoxy, and alkoxy can be unsubstituted or substituted with one or more halo, -OCH 3, -OCF 3, -OH, - NH 2, alkyl, OR 6, oxo, -N 0-2 -R 6, -CN, -C N(R 6) 2, C R 6, C OR 6, -N(R 6) 2, NHC R 6, -SO 2 (R 6), - SO 2 N(R 6) 2, OSO 2 R 6, -CH 2 N(R 6) 2, -CH 2 NHC R 6, -OC R 6, aryl, NHC (R 6), O-aryl, het, O-het, or cycloalkyl; R 6 is H, alkyl, alkenyl, aryl, het, or two R 6 on one atom may form cycloalkyl, aryl, or het; and alkyl, alkenyl, aryl, het, cycloalkyl, or het may be unsubstituted or substituted by OH, oxo, alkoxy, NR 6, Nalkyl, acyl, aryl or het group; het is a 5-7 membered monocyclic heterocyclic ring which may be aromatic or non-aromatic, containing 1-4 heteroring atoms selected from N, O, and S; or an 8-12 membered fused ring system that includes at least one 5-7 membered heterocyclic ring which may be aromatic or non-aromatic, containing 1, 2, or 3 heteroring atoms selected from N, O and S, which het is unsubstituted or substituted; aryl is an aromatic radical having 6 to 14 ring carbon atoms, and no ring heteroatoms, in which said aryl group may be monocyclic or fused bicyclic or tricyclic, which may be unsubstituted or substituted by one or more substituents; and n is 0, 1, 2, or 3, or a compound selected from the group consisting of those of the structure or a pharmaceutically acceptable salt thereof.