An isolated antibody that specifically binds a first polyubiquitin comprising a K11 lysine linkage, wherein the antibody does not specifically bind a second polyubiquitin comprising a second lysine linkage which differs from a K11 lysine linkage, comprising: a) a hypervariable -L1 sequence of SEQ ID NO: 59, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 67 and a HVR-H3 sequence of SEQ ID NO: 23; or b) a HVR-L1 sequence of SEQ ID NO: 58, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 67, and a HVR-H3 sequence of SEQ ID NO: 23; or c) a HVR-L1 sequence of SEQ ID NO: 60, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 17, and a HVR-H3 sequence of SEQ ID NO: 23; or d) a HVR-L1 sequence of SEQ ID NO: 2, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 17, and a HVR-H3 sequence of SEQ ID NO: 23; or e) HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2, and HVR-H3 sequences, respectively, of SEQ ID NOs: 2, 3, 4, 6, 12, and 18; SEQ ID NOs: 2, 3, 4, 7, 13, and 19; SEQ ID NOs: 2, 3, 4, 8, 14, and 20; SEQ ID NOs: 2, 3, 4, 9, 15, and 21; or SEQ ID NOs: 2, 3, 4, 10, 16, and 22; or f) HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2, and HVR-H3 sequences, respectively, of SEQ ID NO: 57, 3, 4, 11, 17, and 23; SEQ ID NO: 58, 3, 4, 11, 17, and 23; SEQ ID NO: 2, 61, 4, 11, 17, and 23; SEQ ID NO: 59, 3, 4, 11, 17, and 23; SEQ ID NO: 2, 3, 4, 11, 17, and 68; SEQ ID NO: 2, 3, 4, 11, 17, and 69; or SEQ ID NO: 2, 3, 4, 11, 67, and 23; or g) a combination of light and heavy chain variable region sequences selected from: SEQ ID NOs 5 and 32; SEQ ID NOs: 63 and 32; SEQ ID NOs: 65 and 32; SEQ ID NOs: 5 and 72; SEQ ID NOs: 63 and 72; and SEQ ID NOs: 65 and 72; SEQ ID NOs: 62 and 32; SEQ ID NOs: 64 and 32; SEQ ID NOs: 5 and 70; SEQ ID NOs: 5 and 71; SEQ ID NOs: 66 and 32; SEQ ID NOs: 5 and 27; SEQ ID NOs: 5 and 28; SEQ ID NOs: 5 and 29; SEQ ID NOs: 5 and 30; or SEQ ID NOs: 5 and 31. a) a hypervariable -L1 sequence of SEQ ID NO: 59, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 67 and a HVR-H3 sequence of SEQ ID NO: 23; or b) a HVR-L1 sequence of SEQ ID NO: 58, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 67, and a HVR-H3 sequence of SEQ ID NO: 23; or c) a HVR-L1 sequence of SEQ ID NO: 60, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 17, and a HVR-H3 sequence of SEQ ID NO: 23; or d) a HVR-L1 sequence of SEQ ID NO: 2, a HVR-L2 sequence of SEQ ID NO: 3, a HVR-L3 sequence of SEQ ID NO: 4, a HVR-H1 sequence of SEQ ID NO: 11, a HVR-H2 sequence of SEQ ID NO: 17, and a HVR-H3 sequence of SEQ ID NO: 23; or e) HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2, and HVR-H3 sequences, respectively, of SEQ ID NOs: 2, 3, 4, 6, 12, and 18; SEQ ID NOs: 2, 3, 4, 7, 13, and 19; SEQ ID NOs: 2, 3, 4, 8, 14, and 20; SEQ ID NOs: 2, 3, 4, 9, 15, and 21; or SEQ ID NOs: 2, 3, 4, 10, 16, and 22; or f) HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2, and HVR-H3 sequences, respectively, of SEQ ID NO: 57, 3, 4, 11, 17, and 23; SEQ ID NO: 58, 3, 4, 11, 17, and 23; SEQ ID NO: 2, 61, 4, 11, 17, and 23; SEQ ID NO: 59, 3, 4, 11, 17, and 23; SEQ ID NO: 2, 3, 4, 11, 17, and 68; SEQ ID NO: 2, 3, 4, 11, 17, and 69; or SEQ ID NO: 2, 3, 4, 11, 67, and 23; or g) a combination of light and heavy chain variable region sequences selected from: SEQ ID NOs 5 and 32; SEQ ID NOs: 63 and 32; SEQ ID NOs: 65 and 32; SEQ ID NOs: 5 and 72; SEQ ID NOs: 63 and 72; and SEQ ID NOs: 65 and 72; SEQ ID NOs: 62 and 32; SEQ ID NOs: 64 and 32; SEQ ID NOs: 5 and 70; SEQ ID NOs: 5 and 71; SEQ ID NOs: 66 and 32; SEQ ID NOs: 5 and 27; SEQ ID NOs: 5 and 28; SEQ ID NOs: 5 and 29; SEQ ID NOs: 5 and 30; or SEQ ID NOs: 5 and 31.