A tablet splitting apparatus (20, 20A, 20B) comprising: a guide (31, 31A) having a guide passage (32, 32A) for guiding a falling tablet; a catcher for receiving a tablet moving downward through the guide passage (32, 32A) in the middle of the guide passage (32, 32A); and a splitting mechanism (40, 40A, 40B) for splitting the tablet received by the catcher, wherein the splitting mechanism (40, 40A, 40B) comprises a pair of blade shifters (43, 44) that allow respective blades (41, 42) for splitting the tablet received by the catcher to be attached to predetermined positions of the blade shifters, characterized in that it further comprises a housing in which the guide (31, 31A), the catcher, and the splitting mechanism (40, 40A, 40B) are accommodated, the housing comprising an opening allowing the guide (31, 31A) and the blades (41, 42) to move therethrough and a support (28, 28A, 28B) detachably fixing the guide (31, 31A) at a supporting position in the housing, the support (28, 28A, 28B) and the guide (31, 31A) each comprise a sliding portion for fixing the guide (31, 31A), and the support (28, 28A, 28B) and the guide (31, 31A) are in a slidable contact with each other at the sliding portions while the guide (31, 31A) is supported at the supporting position, the guide (31, 31A) disposed at the supporting position is slid along the sliding portion of the support (28, 28A, 28B) so as to be detachable from the supporting position through the opening, the blades (41, 42) and the blade shifters (43, 44) each comprise a sliding portion at which each of the blades (41, 42) is attached to a corresponding one of the blade shifters (43, 44) or at which each of the blade shifters (43, 44) allows a corresponding one of the blades (41, 42) to be attached thereto, and the blades (41, 42) and the blade shifters (43, 44) are in a slidable contact with each other at the sliding portions while the blades (41, 42) are attached to the respective predetermined positions, and the blades (41, 42) attached to the respective predetermined positions of the blade shifters (43, 44) are slid along the sliding portions of the blade shifters (43, 44) so as to be detachable from the blade shifters (43, 44) through the opening. a guide (31, 31A) having a guide passage (32, 32A) for guiding a falling tablet; a catcher for receiving a tablet moving downward through the guide passage (32, 32A) in the middle of the guide passage (32, 32A); and a splitting mechanism (40, 40A, 40B) for splitting the tablet received by the catcher, wherein the splitting mechanism (40, 40A, 40B) comprises a pair of blade shifters (43, 44) that allow respective blades (41, 42) for splitting the tablet received by the catcher to be attached to predetermined positions of the blade shifters, characterized in that it further comprises a housing in which the guide (31, 31A), the catcher, and the splitting mechanism (40, 40A, 40B) are accommodated, the housing comprising an opening allowing the guide (31, 31A) and the blades (41, 42) to move therethrough and a support (28, 28A, 28B) detachably fixing the guide (31, 31A) at a supporting position in the housing, the support (28, 28A, 28B) and the guide (31, 31A) each comprise a sliding portion for fixing the guide (31, 31A), and the support (28, 28A, 28B) and the guide (31, 31A) are in a slidable contact with each other at the sliding portions while the guide (31, 31A) is supported at the supporting position, the guide (31, 31A) disposed at the supporting position is slid along the sliding portion of the support (28, 28A, 28B) so as to be detachable from the supporting position through the opening, the blades (41, 42) and the blade shifters (43, 44) each comprise a sliding portion at which each of the blades (41, 42) is attached to a corresponding one of the blade shifters (43, 44) or at which each of the blade shifters (43, 44) allows a corresponding one of the blades (41, 42) to be attached thereto, and the blades (41, 42) and the blade shifters (43, 44) are in a slidable contact with each other at the sliding portions while the blades (41, 42) are attached to the respective predetermined positions, and the blades (41, 42) attached to the respective predetermined positions of the blade shifters (43, 44) are slid along the sliding portions of the blade shifters (43, 44) so as to be detachable from the blade shifters (43, 44) through the opening.