A method for detecting a hematological disorder in a subject, the method comprising: (a) obtaining sequencing reads for cell-free DNA (cfDNA) from a sample of a subject, or amplification products thereof, enriched by contact with a composition comprising a plurality of different bait oligonucleotides, wherein the cfDNA is converted prior to sequencing by treating the cfDNA to convert unmethylated cytosines to uracils, wherein: i) each bait oligonucleotide in the plurality of different bait oligonucleotides is at least 45 nucleotides in length, optionally 45 to 300 nucleotides in length; ii) the plurality of different bait oligonucleotides collectively hybridize to at least 100 target genomic regions; iii) the at least 100 target genomic regions are differentially methylated in at least one HD relative to a different HD; iv) the at least one HD and the different HD are selected from clonal hematopoiesis of indeterminate potential (CHIP), leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm; and (b) using a computer to apply a trained classifier to the sequencing reads to determine a presence or absence of the at least one HD, wherein the classifier is trained using converted DNA sequences, wherein converted DNA relates to DNA that has been treated to convert unmethylated cytosines to uracils, wherein: i) the trained classifier distinguishes between CHIP and one or more HD selected from leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm based on the sequencing reads; and ii) detection of a number of sequencing reads for a plurality of the at least 100 target genomic regions above a threshold identifies the presence of the at least one HD. (a) obtaining sequencing reads for cell-free DNA (cfDNA) from a sample of a subject, or amplification products thereof, enriched by contact with a composition comprising a plurality of different bait oligonucleotides, wherein the cfDNA is converted prior to sequencing by treating the cfDNA to convert unmethylated cytosines to uracils, wherein: i) each bait oligonucleotide in the plurality of different bait oligonucleotides is at least 45 nucleotides in length, optionally 45 to 300 nucleotides in length; ii) the plurality of different bait oligonucleotides collectively hybridize to at least 100 target genomic regions; iii) the at least 100 target genomic regions are differentially methylated in at least one HD relative to a different HD; iv) the at least one HD and the different HD are selected from clonal hematopoiesis of indeterminate potential (CHIP), leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm; and i) each bait oligonucleotide in the plurality of different bait oligonucleotides is at least 45 nucleotides in length, optionally 45 to 300 nucleotides in length; ii) the plurality of different bait oligonucleotides collectively hybridize to at least 100 target genomic regions; iii) the at least 100 target genomic regions are differentially methylated in at least one HD relative to a different HD; iv) the at least one HD and the different HD are selected from clonal hematopoiesis of indeterminate potential (CHIP), leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm; and (b) using a computer to apply a trained classifier to the sequencing reads to determine a presence or absence of the at least one HD, wherein the classifier is trained using converted DNA sequences, wherein converted DNA relates to DNA that has been treated to convert unmethylated cytosines to uracils, wherein: i) the trained classifier distinguishes between CHIP and one or more HD selected from leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm based on the sequencing reads; and ii) detection of a number of sequencing reads for a plurality of the at least 100 target genomic regions above a threshold identifies the presence of the at least one HD. i) the trained classifier distinguishes between CHIP and one or more HD selected from leukemia, lymphoid neoplasms, multiple myeloma, and a myeloid neoplasm based on the sequencing reads; and ii) detection of a number of sequencing reads for a plurality of the at least 100 target genomic regions above a threshold identifies the presence of the at least one HD.