mhurhangee/ep-ind-claims huggingface dataset:
A method of altering tissue tropism of an adeno-associated virus vector, the method comprising: locating an amino acid position within an AAV capsid protein corresponding to position 266 in a capsid protein of Anc80 (SEQ ID NO:1) or corresponding to position 168 in a capsid protein of Anc80 (SEQ ID NO: 1); and replacing a naturally occurring amino acid at the located position corresponding to position 266 in the capsid protein of Anc80 (SEQ ID NO: 1) with a glycine amino acid residue to enhance liver tropism of the resulting AAV vector, or with an alanine amino acid residue to reduce liver tropism of the resulting AAV or replacing a naturally occurring amino acid at the located position corresponding to position 168 in the capsid protein of Anc80 (SEQ ID NO:1) with an arginine amino acid residue to enhance liver tropism of the resulting AAV vector, or with a lysine amino acid residue to reduce liver tropism of the resulting AAV. locating an amino acid position within an AAV capsid protein corresponding to position 266 in a capsid protein of Anc80 (SEQ ID NO:1) or corresponding to position 168 in a capsid protein of Anc80 (SEQ ID NO: 1); and replacing a naturally occurring amino acid at the located position corresponding to position 266 in the capsid protein of Anc80 (SEQ ID NO: 1) with a glycine amino acid residue to enhance liver tropism of the resulting AAV vector, or with an alanine amino acid residue to reduce liver tropism of the resulting AAV or replacing a naturally occurring amino acid at the located position corresponding to position 168 in the capsid protein of Anc80 (SEQ ID NO:1) with an arginine amino acid residue to enhance liver tropism of the resulting AAV vector, or with a lysine amino acid residue to reduce liver tropism of the resulting AAV.
A light emitting device comprising: a substrate; a plurality of cluster layers spread over a surface of the substrate; a first semiconductor layer provided over the plurality of cluster layers, wherein the first semiconductor layer includes air gaps provided above the plurality of cluster layers; a light emitting structure including a first conductivity type semiconductor layer adjacent to the first semiconductor layer, an active layer on the first conductivity type semiconductor layer, and a second conductivity type semiconductor layer on the active layer; a first electrode electrically coupled to the first conductivity type semiconductor and a second electrode (173, 181) electrically coupled to the second conductivity type semiconductor; and at least one of a transmittive electrode layer or a reflective electrode layer on the second conductivity type semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer and the air gaps provided on a part of an upper surfaces of the plurality of cluster layers, wherein the plurality of cluster layers is formed of spherical shape, elliptical shape, or polygonal shape, and wherein each of the plurality of cluster layers has a size in a range of 1Å to 9000Å, characterized in that the first semiconductor layer is disposed to contact and at least partially overlap the upper surfaces of the plurality of cluster layers and to overlap the substrate. a substrate; a plurality of cluster layers spread over a surface of the substrate; a first semiconductor layer provided over the plurality of cluster layers, wherein the first semiconductor layer includes air gaps provided above the plurality of cluster layers; a light emitting structure including a first conductivity type semiconductor layer adjacent to the first semiconductor layer, an active layer on the first conductivity type semiconductor layer, and a second conductivity type semiconductor layer on the active layer; a first electrode electrically coupled to the first conductivity type semiconductor and a second electrode (173, 181) electrically coupled to the second conductivity type semiconductor; and at least one of a transmittive electrode layer or a reflective electrode layer on the second conductivity type semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer and the air gaps provided on a part of an upper surfaces of the plurality of cluster layers, wherein the plurality of cluster layers is formed of spherical shape, elliptical shape, or polygonal shape, and wherein each of the plurality of cluster layers has a size in a range of 1Å to 9000Å, characterized in that the first semiconductor layer is disposed to contact and at least partially overlap the upper surfaces of the plurality of cluster layers and to overlap the substrate.
The use of N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide of formula or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a hematological cancer or a hematopoietic malignancy which is multiple myeloma.
A reinforcement mat, comprising at least one carrier layer and at least one cover layer, wherein the cover layer consists of a non-woven, and the carrier layer of a non-woven or woven fabric or knitted fabric, and the layers are connected to one another, characterised in that at least the carrier layer or the cover layer are designed in an hydrophobic manner.
Parking valve for a trailer of a utility vehicle with a) an output port for a bias of a spring-loaded parking brake with pressurised air, b) a supply port for the supply of pressurised air, c) a deaeration and d) a manual actuation means by which it is possible to manually switch the parking valve da) between an aerating position in which the supply port is connected to the output port and db) a deaerating position in which the output port is connected to the deaeration, characterised by e) the parking valve comprising a pressure protection valve which in the aerating position is interposed between the supply port and the output port and in the aerating position of the actuation means ea) protects a pressure at the output port against a pressure loss at the supply port, wherein eb) the effect of the pressure protection valve is cancelled if - the pressure at the supply port or - the pressure difference between the pressure at the supply port and the pressure at the output port falls below a threshold value. a) an output port for a bias of a spring-loaded parking brake with pressurised air, b) a supply port for the supply of pressurised air, c) a deaeration and d) a manual actuation means by which it is possible to manually switch the parking valve da) between an aerating position in which the supply port is connected to the output port and db) a deaerating position in which the output port is connected to the deaeration, characterised by da) between an aerating position in which the supply port is connected to the output port and db) a deaerating position in which the output port is connected to the deaeration, e) the parking valve comprising a pressure protection valve which in the aerating position is interposed between the supply port and the output port and in the aerating position of the actuation means ea) protects a pressure at the output port against a pressure loss at the supply port, wherein eb) the effect of the pressure protection valve is cancelled if - the pressure at the supply port or - the pressure difference between the pressure at the supply port and the pressure at the output port falls below a threshold value. ea) protects a pressure at the output port against a pressure loss at the supply port, wherein eb) the effect of the pressure protection valve is cancelled if - the pressure at the supply port or - the pressure difference between the pressure at the supply port and the pressure at the output port falls below a threshold value. - the pressure at the supply port or - the pressure difference between the pressure at the supply port and the pressure at the output port
A circuit comprising: one or more clock circuits; a first delay line configured to generate a first delay output, the first delay line comprising m delay elements, wherein m is an integer greater than 0; a second delay line configured to generate a second delay output, the second delay line comprising m + n delay elements (220a-c), wherein n is an integer greater than 0, and wherein the first delay line and the second delay line receive a reference clock signal (REFCLK) from at least one of the one or more clock circuits; a delay-measure circuit (230,242,244,400), configured to: generate an offset pulse based on the first delay output and the second delay output; generate a delay measure based on the offset pulse; and output the delay measure; and an application circuit configured to: receive the delay measure and at least one input signal, wherein the at least one input signal is different from the reference clock signal; adjust the at least one input signal based on the delay measure to generate at least one delay-compensated output signal; and output the at least one output signal. one or more clock circuits; a first delay line configured to generate a first delay output, the first delay line comprising m delay elements, wherein m is an integer greater than 0; a second delay line configured to generate a second delay output, the second delay line comprising m + n delay elements (220a-c), wherein n is an integer greater than 0, and wherein the first delay line and the second delay line receive a reference clock signal (REFCLK) from at least one of the one or more clock circuits; a delay-measure circuit (230,242,244,400), configured to: generate an offset pulse based on the first delay output and the second delay output; generate a delay measure based on the offset pulse; and output the delay measure; and generate an offset pulse based on the first delay output and the second delay output; generate a delay measure based on the offset pulse; and output the delay measure; and an application circuit configured to: receive the delay measure and at least one input signal, wherein the at least one input signal is different from the reference clock signal; adjust the at least one input signal based on the delay measure to generate at least one delay-compensated output signal; and output the at least one output signal. receive the delay measure and at least one input signal, wherein the at least one input signal is different from the reference clock signal; adjust the at least one input signal based on the delay measure to generate at least one delay-compensated output signal; and output the at least one output signal.
Double-clutch transmission of a motor vehicle, having a first input shaft which is embodied as a hollow shaft, and a longer second input shaft which is arranged coaxially within the first input shaft, which first input shaft and second input shaft each have a drive connection, by means of an assigned input constant (EK1, EK2), to at least one layshaft (W3a, W3b) which is arranged axis-parallel with respect to the two input shafts (W1, W2), characterized in that in the case of at least one of the input constants a fixed wheel which is arranged on the assigned input shaft is arranged in a rotationally fixed fashion on a supporting sleeve via a first driving toothing arrangement, which supporting sleeve is itself connected in a rotationally fixed fashion to the respective input shaft via a second driving toothing arrangement (21, 21'), and in that the supporting sleeve and the assigned input shaft are each provided, in an axial region near to the gearwheel, with a toothing section of the second driving toothing arrangement, and in an axial region remote from the gearwheel with a smooth guide section.
A bead reinforcing structure for a heavy duty tire having a bead in which a carcass is turned up to surround a bead core, the bead reinforcing structure comprising: a carcass; and an inside steel chafer having a predetermined inclination angle and an outside steel chafer having a predetermined inclination angle, the inside and outside steel chafers (2, 3) being disposed inside and outside the carcass, respectively, thereby reinforcing the bead from the inside and outside of the carcass, wherein a laminate made up of the inside steel chafer 2, the outside steel chafer 3, and the carcass 1 is turned up in a position at which a bead core 4 is located, and wherein a height of an end of the outside steel chafer which is near the end of the carcass is lower than that of the end of the carcass. a carcass; and an inside steel chafer having a predetermined inclination angle and an outside steel chafer having a predetermined inclination angle, the inside and outside steel chafers (2, 3) being disposed inside and outside the carcass, respectively, thereby reinforcing the bead from the inside and outside of the carcass, wherein a laminate made up of the inside steel chafer 2, the outside steel chafer 3, and the carcass 1 is turned up in a position at which a bead core 4 is located, and wherein a height of an end of the outside steel chafer which is near the end of the carcass is lower than that of the end of the carcass.
Process for preparing amidomethylated vinylaromatic bead polymers, characterized in that at least one vinylaromatic bead polymer is reacted with at least one compound of formula or salts thereof where R 1 = -CH-(C 1 -C 6 -alkyl) or -CH 2 - and R 2 = -CH-(C 1 -C 6 -alkyl) or -CH 2 - or R 1 and R 2 are two carbon atoms of an aromatic C 6 ring optionally substituted by one or two C 1 -C 6 -alkyl radicals, or R 1 and R 2 are each -CH=, and at least one condensed formaldehyde in the presence of at least one protic acid and in the presence of at least one compound of the formula H (3-n)C(Br) nR 3 where R 3 = C 1 -C 4 -alkyl, Br, H or C 1 -C 4 -bromoalkyl and n may be 0 or 1, where, if n = 0, R 3 = C 1 -C 4 -bromoalkyl or Br.
A system for assembling a wind turbine blade shell, the system comprising: - a first support structure comprising a stationary portion and a moveable portion (362, 363), the moveable portion being adapted to support a first wind turbine blade shell half, - a second support structure adapted to support a second wind turbine blade shell half, - moving means attached to the moveable portion and configured to move the moveable portion between: i. a first position in which the moveable portion is positioned above the stationary structure, and ii. a second position in which the moveable portion is positioned above the second support structure, wherein when the moveable portion is in the second position, the first wind turbine blade shell half, when supported by the moveable portion, and the second wind turbine blade shell half, when supported by the second support structure, are assembled, forming the wind turbine blade shell. - a first support structure comprising a stationary portion and a moveable portion (362, 363), the moveable portion being adapted to support a first wind turbine blade shell half, - a second support structure adapted to support a second wind turbine blade shell half, - moving means attached to the moveable portion and configured to move the moveable portion between: i. a first position in which the moveable portion is positioned above the stationary structure, and ii. a second position in which the moveable portion is positioned above the second support structure, wherein when the moveable portion is in the second position, the first wind turbine blade shell half, when supported by the moveable portion, and the second wind turbine blade shell half, when supported by the second support structure, are assembled, forming the wind turbine blade shell. i. a first position in which the moveable portion is positioned above the stationary structure, and ii. a second position in which the moveable portion is positioned above the second support structure, wherein when the moveable portion is in the second position, the first wind turbine blade shell half, when supported by the moveable portion, and the second wind turbine blade shell half, when supported by the second support structure, are assembled, forming the wind turbine blade shell.
An image processing apparatus comprising: an obtaining means for obtaining a first image serving as a read image of an inspection target medium having undergone printing, and a second image serving as a read image of a reference medium representing a target print result; and an inspection means for inspecting a defect on the inspection target medium based on the first image and the second image by performing inspection at inspection settings different between a print region and a peripheral region of the inspection target medium, characterized in that the inspection means is further for detecting a defect in the print region of the inspection target medium by comparing the first image and the second image aligned by a first method, and detecting a defect in the peripheral region of the inspection target medium by comparing the first image and the second image aligned by a second method different from the first method, wherein the inspection means is further for detecting a defect in the peripheral region of the inspection target medium by comparing the first image and the second image aligned based on vertices (308a - 308d) of the inspection target medium and the reference medium, and the inspection means is further for detecting a defect in the print region of the inspection target medium by comparing the first image and the second image aligned based on an object in the first and second image. an obtaining means for obtaining a first image serving as a read image of an inspection target medium having undergone printing, and a second image serving as a read image of a reference medium representing a target print result; and an inspection means for inspecting a defect on the inspection target medium based on the first image and the second image by performing inspection at inspection settings different between a print region and a peripheral region of the inspection target medium, characterized in that the inspection means is further for detecting a defect in the print region of the inspection target medium by comparing the first image and the second image aligned by a first method, and detecting a defect in the peripheral region of the inspection target medium by comparing the first image and the second image aligned by a second method different from the first method, wherein the inspection means is further for detecting a defect in the peripheral region of the inspection target medium by comparing the first image and the second image aligned based on vertices (308a - 308d) of the inspection target medium and the reference medium, and the inspection means is further for detecting a defect in the print region of the inspection target medium by comparing the first image and the second image aligned based on an object in the first and second image.
Method for smoothing an accelerator pedal signal from an active accelerator pedal, the method comprising the steps of: sensing an accelerator pedal raw signal using a sensor; generating haptic feedback at the accelerator pedal by means of an actuator; characterized by the steps of: buffering the accelerator pedal raw signal if no haptic feedback is generated; determining a smoothed accelerator pedal signal on the basis of the stored accelerator pedal raw signal if haptic feedback is generated. sensing an accelerator pedal raw signal using a sensor; generating haptic feedback at the accelerator pedal by means of an actuator; buffering the accelerator pedal raw signal if no haptic feedback is generated; determining a smoothed accelerator pedal signal on the basis of the stored accelerator pedal raw signal if haptic feedback is generated.
A chain block capable of moving a cargo in a vertical direction by transmitting driving force of a handwheel through a drive shaft and a reduction gear member to a load sheave member so as to hoist and lower a load chain wound around the load sheave member, the chain block comprising: a main body frame that has a gear-side frame part housing the reduction gear member and directly or indirectly supporting one end side of the reduction gear member in a rotatable state; a gear cover that is attached to the main body frame by a fixing means to form an internal space sealed off from an outside between the gear cover and the main body frame, and rotatably supports the one end side of the reduction gear member; and an upper hook that is coupled to the gear side frame part via a connecting means, for suspending the main body frame from the upper hook, the gear-side frame part is provided with a bottom part and an outer peripheral wall part projecting from an outer peripheral edge portion of the bottom part, characterising in that, an upper rib having both ends coupled to the outer peripheral wall part is provided at a portion of the gear-side frame part on an upper side where the connecting means is provided and on a side nearer a center of the internal space than is the outer peripheral wall part, and the upper rib is provided adjacent to the connecting means. a main body frame that has a gear-side frame part housing the reduction gear member and directly or indirectly supporting one end side of the reduction gear member in a rotatable state; a gear cover that is attached to the main body frame by a fixing means to form an internal space sealed off from an outside between the gear cover and the main body frame, and rotatably supports the one end side of the reduction gear member; and an upper hook that is coupled to the gear side frame part via a connecting means, for suspending the main body frame from the upper hook, the gear-side frame part is provided with a bottom part and an outer peripheral wall part projecting from an outer peripheral edge portion of the bottom part, characterising in that, an upper rib having both ends coupled to the outer peripheral wall part is provided at a portion of the gear-side frame part on an upper side where the connecting means is provided and on a side nearer a center of the internal space than is the outer peripheral wall part, and the upper rib is provided adjacent to the connecting means.
A wedge connector assembly, comprising: an installation tool including a tool body having an end bearing and a frame connected to said tool body; a firing mechanism movably connected to said tool body; a sleeve received by said frame a wedge received by said sleeve; a movable ram extending from said tool body into said frame and being movable with respect to said tool body; a piston movably disposed in said tool body between said ram and said firing mechanism, said piston being moved when said firing mechanism is activated, thereby driving said wedge into said sleeve; and characterized in that an indicator is disposed on said ram, said indicator being positioned to be visible when the tool body is in a non-firing position and said tool body being movable with respect to said frame where said end bearing covers the indicator in a firing position and to indicate when said installation tool is in a proper firing position to substantially prevent over-torquing said installation tool. an installation tool including a tool body having an end bearing and a frame connected to said tool body; a firing mechanism movably connected to said tool body; a sleeve received by said frame a wedge received by said sleeve; a movable ram extending from said tool body into said frame and being movable with respect to said tool body; a piston movably disposed in said tool body between said ram and said firing mechanism, said piston being moved when said firing mechanism is activated, thereby driving said wedge into said sleeve; and characterized in that an indicator is disposed on said ram, said indicator being positioned to be visible when the tool body is in a non-firing position and said tool body being movable with respect to said frame where said end bearing covers the indicator in a firing position and to indicate when said installation tool is in a proper firing position to substantially prevent over-torquing said installation tool.