mhurhangee/ep-ind-claims huggingface dataset:
A method for processing concurrent services, wherein the concurrent services comprise a first service and a second service; a service priority of the first service is higher than a service priority of the second service; and the method comprises: obtaining, by a terminal, channel quality information of a channel that carries the concurrent services; and blocking, by the terminal, the second service when the channel quality information meets a preset blocking condition; characterized in that the method further comprises: determining, by the terminal, whether a downlink receive power of the channel is less than a first threshold; determining whether a ratio of an uplink transmit power of the channel to a greatest transmit power of the terminal is greater than a second threshold when the downlink receive power of the channel is less than the first threshold; and confirming that the channel quality information meets a preset blocking condition when the downlink receive power of the channel is less than the first threshold and the ratio of the uplink transmit power of the channel to the greatest transmit power of the terminal is greater than the second threshold. obtaining, by a terminal, channel quality information of a channel that carries the concurrent services; and blocking, by the terminal, the second service when the channel quality information meets a preset blocking condition; characterized in that the method further comprises: determining, by the terminal, whether a downlink receive power of the channel is less than a first threshold; determining whether a ratio of an uplink transmit power of the channel to a greatest transmit power of the terminal is greater than a second threshold when the downlink receive power of the channel is less than the first threshold; and confirming that the channel quality information meets a preset blocking condition when the downlink receive power of the channel is less than the first threshold and the ratio of the uplink transmit power of the channel to the greatest transmit power of the terminal is greater than the second threshold. determining, by the terminal, whether a downlink receive power of the channel is less than a first threshold; determining whether a ratio of an uplink transmit power of the channel to a greatest transmit power of the terminal is greater than a second threshold when the downlink receive power of the channel is less than the first threshold; and confirming that the channel quality information meets a preset blocking condition when the downlink receive power of the channel is less than the first threshold and the ratio of the uplink transmit power of the channel to the greatest transmit power of the terminal is greater than the second threshold.
Method for manufacturing moulding elements for moulds intended for moulding tyres provided with a tread comprising a circumferential arrangement of tread pattern elements, the method comprising: a) a step consisting in aligning a plurality of basic linings made of flexible material so as to form a basic tread circumference portion each of the basic linings corresponding to a pattern element of the circumferential arrangement of the tread of the tyre that is to be moulded; b) a step consisting in generating, from the basic tread circumference portion, an intermediate support corresponding to the tread circumference portion; c) a step of obtaining an unfinished moulding element from the intermediate support; characterized in that it moreover comprises a step consisting in cutting the unfinished element to form a plurality of cut elements, the cut elements being able to be assembled in a predetermined order to form a mould portion. a) a step consisting in aligning a plurality of basic linings made of flexible material so as to form a basic tread circumference portion each of the basic linings corresponding to a pattern element of the circumferential arrangement of the tread of the tyre that is to be moulded; b) a step consisting in generating, from the basic tread circumference portion, an intermediate support corresponding to the tread circumference portion; c) a step of obtaining an unfinished moulding element from the intermediate support;
A flow cell (100, 200, 300, 500, 600) comprising: (a) a gasket (305, 405, 505, 605) interposed between a first substrate (110, 210, 310, 510, 610) and a second substrate (111, 211, 311, 511, 611), wherein the gasket, the first substrate and the second substrate are impermeable to aqueous liquid and liquid adhesive, wherein the gasket has a footprint on the first substrate that delineates a channel (201, 301, 501, 601) for containing the aqueous liquid; (b) a via (550, 650) in the gasket, the via containing a solidified liquid adhesive that bonds the first substrate to the second substrate, wherein the solidified liquid adhesive in the via is separated from the channel by the gasket; and (c) a first channel port (120, 220, 320, 520) connecting the channel to the exterior of the flow cell, wherein the first channel port is permeable to the aqueous liquid. (a) a gasket (305, 405, 505, 605) interposed between a first substrate (110, 210, 310, 510, 610) and a second substrate (111, 211, 311, 511, 611), wherein the gasket, the first substrate and the second substrate are impermeable to aqueous liquid and liquid adhesive, wherein the gasket has a footprint on the first substrate that delineates a channel (201, 301, 501, 601) for containing the aqueous liquid; (b) a via (550, 650) in the gasket, the via containing a solidified liquid adhesive that bonds the first substrate to the second substrate, wherein the solidified liquid adhesive in the via is separated from the channel by the gasket; and (c) a first channel port (120, 220, 320, 520) connecting the channel to the exterior of the flow cell, wherein the first channel port is permeable to the aqueous liquid.
A kit suitable for the treatment of Huntington's disease for allele or non-allele-specific huntingtin gene editing or repair comprising a gene delivery vector consisting of: one or more nucleic acid sequences of at least one viral vector selected from the group consisting of adeno-associated vector serotypes and lentiviral vectors; at least one nucleic acid sequence that encodes a Cas9 being human codon-optimized or fused to an epitope tag selected among the group of FLAG, His, myc, Tap, HA, V5; at least one nucleic acid sequence that encodes at least one artificial single guide RNA (sgRNA) having a total size from 63-115 nucleotides comprising a tracrRNA sequence of 48-85 nucleotides long and a crRNA sequence encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS: 4-7 and 13-39 and recognizing the sequence of the HTT gene within the region defined by position 3066800 to position 3086939 excluding the expanded CAG repeat mutation (ENSG00000197386, position of the first CAG repeat in exon 1: 3'074'877-3'074'879), wherein said crRNA sequence binds directly upstream of the required 5'-NGG/NAG-3' protospacer adjacent motif and whereas said crRNA sequence base-pairs with the target HTT sequence and Cas9 mediates a double-stranded break 3-4 bp upstream of said PAM. one or more nucleic acid sequences of at least one viral vector selected from the group consisting of adeno-associated vector serotypes and lentiviral vectors; at least one nucleic acid sequence that encodes a Cas9 being human codon-optimized or fused to an epitope tag selected among the group of FLAG, His, myc, Tap, HA, V5; at least one nucleic acid sequence that encodes at least one artificial single guide RNA (sgRNA) having a total size from 63-115 nucleotides comprising a tracrRNA sequence of 48-85 nucleotides long and a crRNA sequence encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS: 4-7 and 13-39 and recognizing the sequence of the HTT gene within the region defined by position 3066800 to position 3086939 excluding the expanded CAG repeat mutation (ENSG00000197386, position of the first CAG repeat in exon 1: 3'074'877-3'074'879), wherein said crRNA sequence binds directly upstream of the required 5'-NGG/NAG-3' protospacer adjacent motif and whereas said crRNA sequence base-pairs with the target HTT sequence and Cas9 mediates a double-stranded break 3-4 bp upstream of said PAM.
A method of printing an aqueous ink on a recording substrate; the aqueous ink composition comprises particles of a water dispersible colorant and has a pH of between 8 and 12; the method comprising the steps of: a) pretreating the recording substrate by at least partial acidification of the recording substrate, the at least partial acidification being performed by subjecting the recording substrate to a gaseous acid or by subjecting the recording substrate to a plasma treatment; b) imagewise printing the ink composition on the pretreated recording substrate. a) pretreating the recording substrate by at least partial acidification of the recording substrate, the at least partial acidification being performed by subjecting the recording substrate to a gaseous acid or by subjecting the recording substrate to a plasma treatment; b) imagewise printing the ink composition on the pretreated recording substrate.
Hand-guided working implement with a drive motor and an energy supply unit for the drive motor, wherein the energy supply unit is located in a receptacle of a housing of the working implement, wherein the working implement has an impeller for delivering cooling air, wherein the impeller is driven by the drive motor, wherein the housing has at least one air inlet for cooling air, via which the impeller draws in a first cooling air stream in operation, wherein a second cooling air stream is drawn into the housing via the receptacle of the energy supply unit, characterised in that the working implement has an electronic control unit, and in that a first gap, via which the second cooling air stream is drawn in, is formed between the energy supply unit and the edge of the receptacle.
A water turbine arrangement for extracting energy from a flow of water, the water turbine arrangement comprising: a turbine; at least one blade (18, 30) mounted for rotation and mechanically coupled to the turbine, the at least one blade, in use, rotating in dependence on flow of water to thereby rotate the turbine, each at least one blade being mounted such that the blade pitch is unchangeable, the water turbine arrangement being configured such that: the at least one blade (18, 30) and the turbine rotate in a same direction irrespective of whether the flow of water is in a first direction or in a second, opposite direction; and the at least one blade is unencircled by part of the water turbine arrangement radially of a distal end of the at least one blade whereby the water turbine arrangement is shroudless, characterised in that the water turbine arrangement further comprises a motor which is mechanically coupled to the turbine and which is operative to start rotation of the turbine. a turbine; at least one blade (18, 30) mounted for rotation and mechanically coupled to the turbine, the at least one blade, in use, rotating in dependence on flow of water to thereby rotate the turbine, each at least one blade being mounted such that the blade pitch is unchangeable, the water turbine arrangement being configured such that: the at least one blade (18, 30) and the turbine rotate in a same direction irrespective of whether the flow of water is in a first direction or in a second, opposite direction; and the at least one blade is unencircled by part of the water turbine arrangement radially of a distal end of the at least one blade whereby the water turbine arrangement is shroudless, characterised in that the water turbine arrangement further comprises a motor which is mechanically coupled to the turbine and which is operative to start rotation of the turbine.
A heat exchanger comprising an arrangement of heat transfer surfaces and a pair of vertical steam/water separators structurally interconnected to one another and providing an integral support structure for at least a portion of the heat transfer surfaces of the heat exchanger, wherein the structural interconnection includes upper and lower structural members extending between the vertical steam/water separators and formed of heavy wall pipe, said heat exchanger being characterized in that it includes a pair of spaced partition walls disposed in crosswise fashion within the heavy wall pipe to form a central portion therein, which is a header.
A cyclic peptide which comprises the amino acid sequence represented by formula: X 1 -His-Pro-X 4 -Leu-X 6 -X 7 -X 8 -Ser-X 10 -His-Phe in the cycle and has an activity to specifically bind to human CTLA-4, wherein X 1, X 4, X 6, X 7, X 8 and X 10 are each independently any amino acid. in the cycle and has an activity to specifically bind to human CTLA-4, wherein X 1, X 4, X 6, X 7, X 8 and X 10 are each independently any amino acid.
An absorbent article comprising: a central lateral axis; a central longitudinal axis; a liquid permeable topsheet; a liquid impermeable backsheet; an absorbent core positioned at least partially intermediate the liquid permeable topsheet and the liquid impermeable backsheet; a first waist region; a second waist region; a crotch region extending intermediate the first waist region and the second waist region; an outer cover material joined to the backsheet and forming a portion of a garment-facing surface of the absorbent article; a pair of leg cuffs; a pair of crotch narrowing joints in the crotch region, wherein the pair of crotch narrowing joints each comprise a bond positioned between a portion of the backsheet and a portion of the leg cuffs; and the absorbent article comprising: a discrete wetness guard in the first waist region or the second waist region, wherein the wetness guard comprises: a first liquid impermeable layer facing the topsheet; and a liquid permeable layer forming a portion of the wearer-facing surface, and wherein the wetness guard forms a portion of a wearer-facing surface of the absorbent article. a central lateral axis; a central longitudinal axis; a liquid permeable topsheet; a liquid impermeable backsheet; an absorbent core positioned at least partially intermediate the liquid permeable topsheet and the liquid impermeable backsheet; a first waist region; a second waist region; a crotch region extending intermediate the first waist region and the second waist region; an outer cover material joined to the backsheet and forming a portion of a garment-facing surface of the absorbent article; a pair of leg cuffs; a pair of crotch narrowing joints in the crotch region, wherein the pair of crotch narrowing joints each comprise a bond positioned between a portion of the backsheet and a portion of the leg cuffs; and the absorbent article comprising: a discrete wetness guard in the first waist region or the second waist region, wherein the wetness guard comprises: a first liquid impermeable layer facing the topsheet; and a liquid permeable layer forming a portion of the wearer-facing surface, and wherein the wetness guard forms a portion of a wearer-facing surface of the absorbent article.
A trolley for a trailer having a quadrangular frame, which has rollers or wheels at its corners, wherein the frame has at least one push-up rail, inclinedly arranged on a lower side of the frame in a transverse direction, which extends across the width of the frame, characterised in that two or more push-up rails with opposite inclination are provided.
A wall formwork with a sealing system for closing an anchor hole of the wall formwork or for sealing an anchor rod in the anchor hole of the wall formwork, comprising an anchor seal for sealing an anchor rod and a closure cap for closing said anchor hole, characterized in that the anchor seal and the closure cap can be detachably connected to said anchor hole in the formwork facing, said anchor hole being provided by an adapter, which can be detachably connected to an opening (12a, 12b) in the formwork facing (12a, 12b).
A blend composition of ethylene vinyl acetate copolymer, peroxide curable polyacrylate elastomer, and polyamide, said blend composition consisting essentially of from 10wt% to 98wt% of an ethylene vinyl acetate copolymer component said ethylene copolymer component comprising one or more ethylene vinyl acetate copolymers of at least 40% by weight copolymerized vinyl acetate monomer units; and from 1wt% to about 50wt% of a one or more of peroxide curable polyacrylate elastomer component comprising copolymerized units of alkyl acrylate, and at least 0.03 mol % of an amine or acid reactive monomer selected from the group consisting of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and unsaturated epoxides; and from 1wt% to 60wt% of a polyamide component comprising one or more polyamides having a melting peak temperature of at least 160°C, wherein said blend composition has a Mooney viscosity (ML 1+4, 100°C) determined according to ASTM D1646 of 5 to 200; and wherein each of the weight percentages of the ethylene vinyl acetate copolymer, polyacrylate elastomer, and polyamide components are based on the combined weight of the ethylene vinyl acetate copolymers, polyacrylate elastomers, and polyamides in the blend composition. from 10wt% to 98wt% of an ethylene vinyl acetate copolymer component said ethylene copolymer component comprising one or more ethylene vinyl acetate copolymers of at least 40% by weight copolymerized vinyl acetate monomer units; and from 1wt% to about 50wt% of a one or more of peroxide curable polyacrylate elastomer component comprising copolymerized units of alkyl acrylate, and at least 0.03 mol % of an amine or acid reactive monomer selected from the group consisting of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and unsaturated epoxides; and from 1wt% to 60wt% of a polyamide component comprising one or more polyamides having a melting peak temperature of at least 160°C,
A process for the preparation of 5-[[(2R,3S)-2-[ -1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one (Aprepitant) of formula I, comprising the steps of: (a) condensing 2- -[ -1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3- -(4-fluorophenyl)morpholine hydrochloride salt of formula II with 2-(2-chloro-l-iminoethyl)hydrazinecarboxylic acid methyl ester of formula III in the presence of potassium carbonate and dimethylsulfoxide to obtain a reaction mixture containing 2-[2-[(2R,3S)-2-[ -1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester of formula IV; (b) in-situ cyclizing the reaction mixture containing compound of formula IV to the compound of formula I by heating said reaction mixture in a mixture of dimethylsulfoxide and a polar protic solvent at a temperature of 90-110°C and (c) isolating aprepitant of formula I, wherein the steps (a) and (b) are carried out without isolating intermediates from the reaction mixture. (a) condensing 2- -[ -1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3- -(4-fluorophenyl)morpholine hydrochloride salt of formula II with 2-(2-chloro-l-iminoethyl)hydrazinecarboxylic acid methyl ester of formula III in the presence of potassium carbonate and dimethylsulfoxide to obtain a reaction mixture containing 2-[2-[(2R,3S)-2-[ -1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester of formula IV; (b) in-situ cyclizing the reaction mixture containing compound of formula IV to the compound of formula I by heating said reaction mixture in a mixture of dimethylsulfoxide and a polar protic solvent at a temperature of 90-110°C and (c) isolating aprepitant of formula I, wherein the steps (a) and (b) are carried out without isolating intermediates from the reaction mixture.
A method for controlling an internal combustion engine, provided with a device for depollution of exhaust gas, the depollution device being regenerated periodically by injection of fuel in the combustion chamber of the engine, the method including the steps of: - determining the distance remaining to be covered up to the next change of lubricating oil of the engine; - on the basis of the current frequency of the regeneration fuel injections, calculating the concentration of fuel in the oil which is foreseeable at the next oil change; - if the calculated concentrated exceeds a predetermined threshold, calculating a regeneration injection frequency for which the concentration of fuel in the oil which is foreseeable at the next oil change is less than said predetermined threshold, carrying out regeneration injections with said calculated frequency. - determining the distance remaining to be covered up to the next change of lubricating oil of the engine; - on the basis of the current frequency of the regeneration fuel injections, calculating the concentration of fuel in the oil which is foreseeable at the next oil change; - if the calculated concentrated exceeds a predetermined threshold, calculating a regeneration injection frequency for which the concentration of fuel in the oil which is foreseeable at the next oil change is less than said predetermined threshold, carrying out regeneration injections with said calculated frequency.
Composition comprising the constituents water, electroconductive nanoobjects, said electroconductive nanoobjects having two external dimensions in the range of from 1 nm to 100 nm and their third external dimension in the range of from 1 μm to 100 μm wherein the weight fraction of said electroconductive nanoobjects is in the range of from 0.01 wt.-% to 1 wt.-% based on the total weight of the composition, dissolved in the water one or more styrene/(meth)acrylic copolymers, said dissolved copolymers each having a number average molecular weight in the range of from 500 g/mol to 22000 g/mol wherein the total weight fraction of said dissolved copolymers is in the range of from 0.02 wt.-% to 5 wt.-%, based on the total weight of the composition with the proviso that when the composition comprises one or more additional binding agents which are capable of co-acting with the above-defined one or more copolymers in forming a matrix and binding said electroconductive nanoobjects, the total weight fraction of said additional binding agents, based on the total weight of the composition, is equal to or less than the total weight fraction of said dissolved copolymers based on the total weight of the composition. water, electroconductive nanoobjects, said electroconductive nanoobjects having two external dimensions in the range of from 1 nm to 100 nm and their third external dimension in the range of from 1 μm to 100 μm wherein the weight fraction of said electroconductive nanoobjects is in the range of from 0.01 wt.-% to 1 wt.-% based on the total weight of the composition, dissolved in the water one or more styrene/(meth)acrylic copolymers, said dissolved copolymers each having a number average molecular weight in the range of from 500 g/mol to 22000 g/mol wherein the total weight fraction of said dissolved copolymers is in the range of from 0.02 wt.-% to 5 wt.-%, based on the total weight of the composition