A method for measuring reactive hyperemia in a subject, comprising: performing a first segmental cuff plethysmography having an inflation phase and a deflation phase; generating a baseline arterial compliance curve and/or a baseline pressure-area (P-A) curve on a portion of the body of the subject, wherein the cuff pressure is increased to a first peak cuff pressure during the inflation phase and immediately reduced from the first peak cuff pressure during the deflation phase; performing a second segmental cuff plethysmography having an inflation phase, a holding phase, and a deflation phase; generating a hyperemic arterial compliance curve and/or a hyperemic P-A curve, wherein the cuff pressure is increased to a second peak level during the inflation phase, maintained at the second peak cuff pressure for a predetermined period of time during the holding phase, and then reduced from the second peak cuff pressure during the deflation phase; calculating the difference between the baseline arterial compliance curve and the hyperemic arterial compliance curve as an area between the arterial compliance curves, and/or the difference between the baseline P-A curve and the hyperemic P-A curve as an area between the PA curves; and measuring a level of reactive hyperemia based on the area between the arterial compliance curves and/or the area between the P-A curves, wherein a first cuff compliance curve is generated during the first segmental cuff plethysmography based only on data collected during the deflation phase of the first segmental cuff plethysmography and a second cuff compliance curve is generated during the second segmental cuff plethysmography based only on data collected during the deflation phase of the second segmental cuff plethysmography and wherein said first and second cuff compliance curves are generated using a flowmeter that directly measures the volume change in the cuff during the deflation phase. performing a first segmental cuff plethysmography having an inflation phase and a deflation phase; generating a baseline arterial compliance curve and/or a baseline pressure-area (P-A) curve on a portion of the body of the subject, wherein the cuff pressure is increased to a first peak cuff pressure during the inflation phase and immediately reduced from the first peak cuff pressure during the deflation phase; performing a second segmental cuff plethysmography having an inflation phase, a holding phase, and a deflation phase; generating a hyperemic arterial compliance curve and/or a hyperemic P-A curve, wherein the cuff pressure is increased to a second peak level during the inflation phase, maintained at the second peak cuff pressure for a predetermined period of time during the holding phase, and then reduced from the second peak cuff pressure during the deflation phase; calculating the difference between the baseline arterial compliance curve and the hyperemic arterial compliance curve as an area between the arterial compliance curves, and/or the difference between the baseline P-A curve and the hyperemic P-A curve as an area between the PA curves; and measuring a level of reactive hyperemia based on the area between the arterial compliance curves and/or the area between the P-A curves, wherein a first cuff compliance curve is generated during the first segmental cuff plethysmography based only on data collected during the deflation phase of the first segmental cuff plethysmography and a second cuff compliance curve is generated during the second segmental cuff plethysmography based only on data collected during the deflation phase of the second segmental cuff plethysmography and wherein said first and second cuff compliance curves are generated using a flowmeter that directly measures the volume change in the cuff during the deflation phase.