A device for delivering a drug depot to a site beneath the skin of patient via a cannula having a proximal end and a distal end, the proximal end of the cannula having an opening to receive the drug depot, the distal end of the cannula being configured for insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot, the device comprising: a housing having a top housing end, and a bottom housing end, said housing further defining a housing channel having a housing channel first open end open to said top housing end and a second housing channel open end open to said bottom housing end; a drug cartridge (180; 200, 202; 200d, 202d) defining a depot channel (199; 203, 209; 203d) aligned with said housing channel and configured to slidably accept the drug depot, said drug cartridge (180; 200, 202; 200d, 202d) having at least a first occluding device (194; 208; 208d) configured to at least partially occlude said depot channel (199; 203, 209; 203d) at a first occluding position such that the drug depot cannot pass through said depot channel (199; 203, 209; 203d) at said first occluding position without force, greater than that of gravity, applied to the drug depot sufficient to deflect said first occluding device (194; 208; 208d) an amount permitting passage of the drug depot past said first occluding device (194; 208; 208d); wherein said drug cartridge (180; 200, 202; 200d, 202d) includes a second occluding device (196; 208; 208d) configured to at least partially occlude said depot channel (199; 203, 209; 203d) at a second occluding position, spaced apart from said first occluding position, such that the drug depot cannot pass through said depot channel (199; 203, 209; 203d) at said second occluding position without force, greater than that of gravity, applied to the drug depot sufficient to deflect said second occluding device (196; 208; 208d) an amount permitting passage of the drug depot past said second occluding device (196; 208; 208d), and wherein said first and second occluding devices (194, 196; 208; 208d) are first and second cantilever arms each having a protruding portion (195, 197; 205, 207; 207d) extending into said depot channel (199; 203, 209; 203d) respectively at said first and second occluding positions, said bottom housing end of said housing has a coupling configuration for engaging the proximal end of the cannula; and a plunger having a push rod slidably receivable in said housing channel and the cannula and having a push rod end to contact the drug depot when disposed in said drug cartridge (180; 200, 202; 200d, 202d) and, upon application of force, expel the drug depot through said first occluding device (194; 208; 208d) and the cannula to the site beneath the skin of the patient. a housing having a top housing end, and a bottom housing end, said housing further defining a housing channel having a housing channel first open end open to said top housing end and a second housing channel open end open to said bottom housing end; a drug cartridge (180; 200, 202; 200d, 202d) defining a depot channel (199; 203, 209; 203d) aligned with said housing channel and configured to slidably accept the drug depot, said drug cartridge (180; 200, 202; 200d, 202d) having at least a first occluding device (194; 208; 208d) configured to at least partially occlude said depot channel (199; 203, 209; 203d) at a first occluding position such that the drug depot cannot pass through said depot channel (199; 203, 209; 203d) at said first occluding position without force, greater than that of gravity, applied to the drug depot sufficient to deflect said first occluding device (194; 208; 208d) an amount permitting passage of the drug depot past said first occluding device (194; 208; 208d); wherein said drug cartridge (180; 200, 202; 200d, 202d) includes a second occluding device (196; 208; 208d) configured to at least partially occlude said depot channel (199; 203, 209; 203d) at a second occluding position, spaced apart from said first occluding position, such that the drug depot cannot pass through said depot channel (199; 203, 209; 203d) at said second occluding position without force, greater than that of gravity, applied to the drug depot sufficient to deflect said second occluding device (196; 208; 208d) an amount permitting passage of the drug depot past said second occluding device (196; 208; 208d), and wherein said first and second occluding devices (194, 196; 208; 208d) are first and second cantilever arms each having a protruding portion (195, 197; 205, 207; 207d) extending into said depot channel (199; 203, 209; 203d) respectively at said first and second occluding positions, said bottom housing end of said housing has a coupling configuration for engaging the proximal end of the cannula; and a plunger having a push rod slidably receivable in said housing channel and the cannula and having a push rod end to contact the drug depot when disposed in said drug cartridge (180; 200, 202; 200d, 202d) and, upon application of force, expel the drug depot through said first occluding device (194; 208; 208d) and the cannula to the site beneath the skin of the patient.