A compound of formula I or II where: R 1 is cyclohexenyl, phenyl, pyridinyl, or thienyl, and is substituted with 1 CON(R 9)(R 10) substituent, and is also substituted with 0-3 substituents selected from the group consisting of halo, alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkoxy, cycloalkoxy, hydroxyalkyloxy, and alkoxyalkyloxy; R 2 is hydrogen, halo, alkyl, or alkoxy; R 3 is alkyl; R 4 is phenyl substituted with 0-2 substituents selected from halo, alkyl, alkoxy, and X-Ar 1; R 5 and R 6 are independently selected from hydrogen, nitro, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (benzoyl)alkyl, (CO 2 (R 11))alkyl, (CON(R 11)(R 12))alkyl, (NHCO 2 (R 11))alkyl, (alkylsulfonyl)alkyl, (alkylsulfonylNH)alkyl, alkoxy, haloalkoxy, alkylsulfonyl, and N(R 7)(R 8); R 7 and R 8 are independently selected from hydrogen, alkyl, cyanoalkyl, haloalkyl, (cycloalkyl)alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylsulfonyl, (alkylsulfonyl)alkyl, and SO 2 N(R 11)(R 12); or N(R 7)(R 8) taken together is azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, and is substituted with 0-2 substituents selected from alkyl, hydroxyalkyl, and hydroxy; R 9 is bicyclo[1.1.1]pentanyl; R 10 is hydrogen; R 11 is hydrogen or alkyl; R 12 is hydrogen or alkyl; X is -O- or -NH-; and Ar 1 is phenyl or halophenyl; wherein "alkyl" means a straight or branched alkyl group composed of 1 to 6 carbons; "cycloalkyl" means a monocyclic ring system composed of 3 to 7 carbons; and "hydroxyalkyl" and "alkoxy" include straight and branched isomers composed of 1 to 6 carbon atoms for the alkyl moiety; or a pharmaceutically acceptable salt thereof. R 1 is cyclohexenyl, phenyl, pyridinyl, or thienyl, and is substituted with 1 CON(R 9)(R 10) substituent, and is also substituted with 0-3 substituents selected from the group consisting of halo, alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkoxy, cycloalkoxy, hydroxyalkyloxy, and alkoxyalkyloxy; R 2 is hydrogen, halo, alkyl, or alkoxy; R 3 is alkyl; R 4 is phenyl substituted with 0-2 substituents selected from halo, alkyl, alkoxy, and X-Ar 1; R 5 and R 6 are independently selected from hydrogen, nitro, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (benzoyl)alkyl, (CO 2 (R 11))alkyl, (CON(R 11)(R 12))alkyl, (NHCO 2 (R 11))alkyl, (alkylsulfonyl)alkyl, (alkylsulfonylNH)alkyl, alkoxy, haloalkoxy, alkylsulfonyl, and N(R 7)(R 8); R 7 and R 8 are independently selected from hydrogen, alkyl, cyanoalkyl, haloalkyl, (cycloalkyl)alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylsulfonyl, (alkylsulfonyl)alkyl, and SO 2 N(R 11)(R 12); or N(R 7)(R 8) taken together is azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, and is substituted with 0-2 substituents selected from alkyl, hydroxyalkyl, and hydroxy; R 9 is bicyclo[1.1.1]pentanyl; R 10 is hydrogen; R 11 is hydrogen or alkyl; R 12 is hydrogen or alkyl; X is -O- or -NH-; and Ar 1 is phenyl or halophenyl; wherein "alkyl" means a straight or branched alkyl group composed of 1 to 6 carbons; "cycloalkyl" means a monocyclic ring system composed of 3 to 7 carbons; and "hydroxyalkyl" and "alkoxy" include straight and branched isomers composed of 1 to 6 carbon atoms for the alkyl moiety; or a pharmaceutically acceptable salt thereof.