mhurhangee/ep-ind-claims huggingface dataset:
Valve, especially a pilot-operated proportional pressure control valve, with a valve housing (5, 137) comprising a pressure supply port (7, 119), a service port (9, 121) and a drainage port (11, 123), a main valve piston (15, 125), which can be displaced by a pilot control stage (13, 141), being arranged in the valve housing (5, 137) to control a flow of fluid between the pressure supply port (7, 119) and the service port (9, 121), the pilot control stage (13, 141) comprising a valve closing element (43, 151) for a pilot control chamber (41, 163), the valve closing element (43, 151) being able to be moved by an actuating device (45, 149) from an open position into a closed position, a leakage reduction stage (53, 157) being able to be actuated by the valve closing element (43, 151), said leakage reduction stage (53, 157) comprising a leakage piston (51, 155) coupled to the valve closing element (43, 151), characterised in that the leakage piston (51, 155) controls a flow of fluid between the pressure supply port (7, 119) and the pilot control chamber (41, 163).
A pair of trousers, comprising a waistband system with a circumferential waistband and a closable belt characterised in that the belt is non-elastic and which, at least on a rear side of the pair of trousers, is integrated as a non-elastic waistband portion (11a, 11b) in the waistband, wherein the waistband has at least one waistband portion which is monoelastic at least in the longitudinal direction and can be bridged by means of the belt which extends parallel thereto.
Apparatus for insertion into an imaging system, the apparatus having: a receptacle for a sample holder for a sample, a device for generating a magnetic field in a region of the receptacle for the sample holder, a main body, a recess which forms the receptacle for the sample holder being formed in an upper face, the device for generating a magnetic field being arranged in the main body, characterized in that the device for generating a magnetic field further comprises magnetic field conductors which extend beneath a flat face of the sample holder so as to allow the sample to be immobilized on the sample holder. a receptacle for a sample holder for a sample, a device for generating a magnetic field in a region of the receptacle for the sample holder, a main body, a recess which forms the receptacle for the sample holder being formed in an upper face, the device for generating a magnetic field being arranged in the main body, characterized in that the device for generating a magnetic field further comprises magnetic field conductors which extend beneath a flat face of the sample holder so as to allow the sample to be immobilized on the sample holder.
Pharmaceutical composition comprising metformin and at least one pharmaceutically acceptable carrier, adjuvant and/or excipient for use in treating type !! diabetes mellitus in a patient, wherein the dosage of metformin is adapted by a method comprising (i) administering metformin to a patient, (ii) determining the level of GDF15 or a functional variant thereof in a patient's sample, (iii) comparing the level of GDF15 or a functional variant thereof, determined in step (ii) to a reference, and (iv) adjusting the dosage of metformin in that the treatment with metformin is stopped in case the level of GDF15 or a functional variant thereof is not increased by at least 25%, and the dosage of metformin is maintained or increased in case the level of GDF15 or a functional variant thereof is increased by at least 25%, wherein the GDF15 comprises an amino acid sequences as given in SEQ ID NO:1, and the functional variant thereof has at least 90 % sequence identity to SEQ ID NO: 1. wherein the dosage of metformin is adapted by a method comprising (i) administering metformin to a patient, (ii) determining the level of GDF15 or a functional variant thereof in a patient's sample, (iii) comparing the level of GDF15 or a functional variant thereof, determined in step (ii) to a reference, and (iv) adjusting the dosage of metformin in that the treatment with metformin is stopped in case the level of GDF15 or a functional variant thereof is not increased by at least 25%, and the dosage of metformin is maintained or increased in case the level of GDF15 or a functional variant thereof is increased by at least 25%, (i) administering metformin to a patient, (ii) determining the level of GDF15 or a functional variant thereof in a patient's sample, (iii) comparing the level of GDF15 or a functional variant thereof, determined in step (ii) to a reference, and (iv) adjusting the dosage of metformin in that the treatment with metformin is stopped in case the level of GDF15 or a functional variant thereof is not increased by at least 25%, and the dosage of metformin is maintained or increased in case the level of GDF15 or a functional variant thereof is increased by at least 25%, wherein the GDF15 comprises an amino acid sequences as given in SEQ ID NO:1, and the functional variant thereof has at least 90 % sequence identity to SEQ ID NO: 1.
A control butterfly valve device for an anti-smoke differential pressure unit, having a housing and at least a control butterfly valve (101 to 108) supported to be pivotable about an axis of rotation, wherein, in the closed state, the control butterfly valve (101 to 108) is coupled with at least one first and at least one second restoring device, wherein the first and second restoring device are formed such that restoring forces, that are applicable by the first and second restoring device, counteract opening of the control butterfly valve (101 to 108) up to a predetermined opening pressure acting upon the control butterfly valve (101 to 108), characterized in that a decoupling device is provided to decouple the first restoring device from the control butterfly valve (101 to 108), once the control butterfly valve (101 to 108) is opened by a predetermined opening angle.
A binding molecule comprising - one Ang2-binding component, - one DII4-binding component, and - one serum albumin binding component, wherein said Ang2-, DII4- and serum albumin binding components are immunoglobulin single variable domains, each immunoglobulin single variable domain consisting of four framework regions and three complementarity determining regions (CDRs), and wherein said immunoglobulin single variable domains are VHHs, and wherein said binding molecule comprises - one Ang2-binding VHH, having a CDR1 having the sequence DYAIG, as shown in SEQ ID NO: 513, a CDR2 having the sequence AIRSSGGSTYYADSVKG, as shown in SEQ ID NO: 514, and a CDR3 having the sequence VPAGRLRYGEQWYPIYEYDA, as shown in SEQ ID NO: 515, - the DLLII00018 domain as the DII4-binding component, which domain has the sequence: and - the AlbII domain, as shown in SEQ ID NO: 519, as the serum albumin binding component, in this order. - one Ang2-binding component, - one DII4-binding component, and - one serum albumin binding component, - one Ang2-binding VHH, having a CDR1 having the sequence DYAIG, as shown in SEQ ID NO: 513, a CDR2 having the sequence AIRSSGGSTYYADSVKG, as shown in SEQ ID NO: 514, and a CDR3 having the sequence VPAGRLRYGEQWYPIYEYDA, as shown in SEQ ID NO: 515, - the DLLII00018 domain as the DII4-binding component, which domain has the sequence: and - the AlbII domain, as shown in SEQ ID NO: 519, as the serum albumin binding component,
A car type model comprising: a body (10, 10") formed by a resin; left and right doors to be openably attached to the body (10, 10"); a reinforcing member (20, 20', 20") which is formed of a metal and is to be fixed to an inside of the body (10, 10"); and a chassis (30, 30') to be fixed to the reinforcing member (20, 20', 20"), characterized in that the reinforcing member (20, 20', 20") has a frame portion (29, 29") to which a bottom portion of the body (10, 10"), positioned under the doors, is to be fixed. a body (10, 10") formed by a resin; left and right doors to be openably attached to the body (10, 10"); a reinforcing member (20, 20', 20") which is formed of a metal and is to be fixed to an inside of the body (10, 10"); and a chassis (30, 30') to be fixed to the reinforcing member (20, 20', 20"), characterized in that the reinforcing member (20, 20', 20") has a frame portion (29, 29") to which a bottom portion of the body (10, 10"), positioned under the doors, is to be fixed.
A computer-implemented method for discrete element modelling of a plurality of discrete elements corresponding to particles and physical geometry elements, wherein said modelling performs a simulation through time of physical interactions of the particles with each other and with the physical geometry elements in a three-dimensional space, the method comprising: providing a plurality of discrete element material models, each discrete element material model corresponding to a respective bulk material and containing (i) information regarding the properties of particles within said bulk material, said properties specifying the physical attributes of the particles, and (ii) information regarding the behaviour of interactions between such particles; receiving (420, 430) from a user: (i) a selection of a bulk material for use in a simulation, (ii) a specification of bulk properties associated with the selected bulk material, and (iii) configuration properties (321, 322) imposed during a creation process on particles within the selected bulk material; generating a set of particles of the selected bulk material for use in the simulation based on (i) the discrete element material model for the selected bulk material, (ii) the bulk properties of the bulk material specified by the user, and (iii) the configuration of the creation process; and performing a discrete element model simulation on said set of particles, wherein said simulation uses the information regarding the behaviour of interactions between particles from the discrete element material model for the selected bulk material. providing a plurality of discrete element material models, each discrete element material model corresponding to a respective bulk material and containing (i) information regarding the properties of particles within said bulk material, said properties specifying the physical attributes of the particles, and (ii) information regarding the behaviour of interactions between such particles; receiving (420, 430) from a user: (i) a selection of a bulk material for use in a simulation, (ii) a specification of bulk properties associated with the selected bulk material, and (iii) configuration properties (321, 322) imposed during a creation process on particles within the selected bulk material; generating a set of particles of the selected bulk material for use in the simulation based on (i) the discrete element material model for the selected bulk material, (ii) the bulk properties of the bulk material specified by the user, and (iii) the configuration of the creation process; and performing a discrete element model simulation on said set of particles, wherein said simulation uses the information regarding the behaviour of interactions between particles from the discrete element material model for the selected bulk material.
Polysubstituted pyrimidines of the general formula where X 1 to X 4 are the same or different substituents selected from the group comprising -H, -F, -Cl, alkyl; Y 1 and Y 2 are the same or different substituents selected from the group comprising -H, -F, -Cl, -OR, wherein R is alkyl; R 1 is aryl as defined herein; R 2 is alkyl as defined herein; or a pharmaceutically acceptable salt thereof, wherein alkyl in these cases is defined as a linear or branched C 1 -C 10 carbon chain; aryl in the above cases is defined as a hydrocarbon group containing 6 to 14 carbon atoms containing at least one aromatic ring, wherein the aryl may be unsubstituted or substituted with 1 to 5 substituents selected from the group of -F, -Cl, -OR, wherein R is alkyl as defined herein. X 1 to X 4 are the same or different substituents selected from the group comprising -H, -F, -Cl, alkyl; Y 1 and Y 2 are the same or different substituents selected from the group comprising -H, -F, -Cl, -OR, wherein R is alkyl; R 1 is aryl as defined herein; R 2 is alkyl as defined herein; or a pharmaceutically acceptable salt thereof, wherein alkyl in these cases is defined as a linear or branched C 1 -C 10 carbon chain; aryl in the above cases is defined as a hydrocarbon group containing 6 to 14 carbon atoms containing at least one aromatic ring, wherein the aryl may be unsubstituted or substituted with 1 to 5 substituents selected from the group of -F, -Cl, -OR, wherein R is alkyl as defined herein.
A sidelink control information sending method, wherein the method comprises: obtaining, by a second terminal device, first information, wherein the first information is used to indicate a type of sidelink control information that is sent by the second terminal device to a first terminal device; and sending, the second terminal device, a sidelink control information to the first terminal device based on the first information and the second indication information. wherein the method further comprises: receiving, by the second terminal device, second indication information sent by the first terminal device, wherein the second indication information is used to indicate a type of sidelink control information supported by the first terminal device obtaining, by a second terminal device, first information, wherein the first information is used to indicate a type of sidelink control information that is sent by the second terminal device to a first terminal device; and sending, the second terminal device, a sidelink control information to the first terminal device based on the first information and the second indication information. wherein the method further comprises: receiving, by the second terminal device, second indication information sent by the first terminal device, wherein the second indication information is used to indicate a type of sidelink control information supported by the first terminal device
A computer method comprising: directing a code module of a source code management system to be transferred to a product lifecycle management system in a user request, the user request including supporting data corresponding to the code module extracted from the SCM system, the extracted supporting data representing one or more of hierarchical relationships of other code modules, supporting code modules, and tracking information; creating a PLM system module having the extracted data representing the code module, the hierarchical relationships of other code modules, the supporting code modules, and the tracking information; responsive to an update request, comparing a version of the created PLM system module to a version of the linked module of the SCM system by accessing the tracking information, wherein the tracking information is stored on the SCM system and has a link to the created module of the PLM system, the SCM system thereby retaining a link to the created module; and if the module of the SCM system is a newer version, updating the PLM system module to the newer version of the module of the SCM system. directing a code module of a source code management system to be transferred to a product lifecycle management system in a user request, the user request including supporting data corresponding to the code module extracted from the SCM system, the extracted supporting data representing one or more of hierarchical relationships of other code modules, supporting code modules, and tracking information; creating a PLM system module having the extracted data representing the code module, the hierarchical relationships of other code modules, the supporting code modules, and the tracking information; responsive to an update request, comparing a version of the created PLM system module to a version of the linked module of the SCM system by accessing the tracking information, wherein the tracking information is stored on the SCM system and has a link to the created module of the PLM system, the SCM system thereby retaining a link to the created module; and if the module of the SCM system is a newer version, updating the PLM system module to the newer version of the module of the SCM system.
A boiler for a machine for preparing beverages for heating a liquid pressurized to at least 8 bars to carry out an infusion of a product by the heated liquid, the boiler comprising: • a body having an outer wall covered with a screen-printed resistor and an inner wall, • the inner wall of the body having a longitudinal wall extending in a longitudinal direction and having a circular section, • an inner element having an outer face located opposite to the longitudinal wall of the body for defining, with the longitudinal wall, at least one portion of a heating chamber, • an inlet and an outlet of liquid in the heating chamber, • the inner wall of the body also has at least one bottom wall located at a distal end of the longitudinal wall, • a mounting configured to cooperate with the body so as to form, with the longitudinal wall and the bottom wall, a sealed enclosure comprising the heating chamber, • the bottom wall does not have an opening for the entry or exit of the liquid, characterised in that • the bottom wall has, with the longitudinal wall, a continuity of material. • a body having an outer wall covered with a screen-printed resistor and an inner wall, • the inner wall of the body having a longitudinal wall extending in a longitudinal direction and having a circular section, • an inner element having an outer face located opposite to the longitudinal wall of the body for defining, with the longitudinal wall, at least one portion of a heating chamber, • an inlet and an outlet of liquid in the heating chamber, • the inner wall of the body also has at least one bottom wall located at a distal end of the longitudinal wall, • a mounting configured to cooperate with the body so as to form, with the longitudinal wall and the bottom wall, a sealed enclosure comprising the heating chamber, • the bottom wall does not have an opening for the entry or exit of the liquid, characterised in that • the bottom wall has, with the longitudinal wall, a continuity of material.
A container comprising: a hydrogen generator generating molecular hydrogen; a catalyst catalyzing a chemical reaction between said hydrogen and oxygen, said hydrogen generator and said catalyst combining to provide an oxygen scavenging capacity; and an indication system indicating when said oxygen scavenging capacity has been reduced to or below a predetermined level, characterized in that said indication system comprises an oxygen sensitive label adhesive bonding a label to the container, said oxygen sensitive label adhesive becoming less adhered to said container in the presence of oxygen. a hydrogen generator generating molecular hydrogen; a catalyst catalyzing a chemical reaction between said hydrogen and oxygen, said hydrogen generator and said catalyst combining to provide an oxygen scavenging capacity; and an indication system indicating when said oxygen scavenging capacity has been reduced to or below a predetermined level, characterized in that said indication system comprises an oxygen sensitive label adhesive bonding a label to the container, said oxygen sensitive label adhesive becoming less adhered to said container in the presence of oxygen.
A medical device connector shield (128, 220, 270, 280, 290, 300, 320), comprising: an elongate hollow cylindrical body (185, 240, 282, 292, 302, 322) that extends along a longitudinal axis (a-a); a distal cap portion (163, 180, 238, 274, 284, 294, 304) that extends along the longitudinal axis (a-a) wherein a proximal end of the distal cap portion (163, 180, 238, 274, 284, 294, 304) is connected to a distal end of the elongate hollow cylindrical body (185, 240, 282, 292, 302, 322), wherein the distal cap portion (163, 180, 238, 274, 284, 294, 304) includes a distal face and a sidewall extending between the distal face and the proximal end, and a wire management port (164, 224, 328) defined in the distal cap portion (163, 180, 238, 274, 284, 294, 304) and configured such that one or more leads can pass through, characterized in that the wire management port (164, 224, 328) is disposed off-axis with respect to the longitudinal axis (a-a) and is defined in the sidewall of the distal cap portion (163, 180, 238, 274, 284, 294, 304). an elongate hollow cylindrical body (185, 240, 282, 292, 302, 322) that extends along a longitudinal axis (a-a); a distal cap portion (163, 180, 238, 274, 284, 294, 304) that extends along the longitudinal axis (a-a) wherein a proximal end of the distal cap portion (163, 180, 238, 274, 284, 294, 304) is connected to a distal end of the elongate hollow cylindrical body (185, 240, 282, 292, 302, 322), wherein the distal cap portion (163, 180, 238, 274, 284, 294, 304) includes a distal face and a sidewall extending between the distal face and the proximal end, and a wire management port (164, 224, 328) defined in the distal cap portion (163, 180, 238, 274, 284, 294, 304) and configured such that one or more leads can pass through, characterized in that the wire management port (164, 224, 328) is disposed off-axis with respect to the longitudinal axis (a-a) and is defined in the sidewall of the distal cap portion (163, 180, 238, 274, 284, 294, 304).