An apparatus comprising: a rotational drive motor coupled to a drive member (58, 146); a hemostasis valve including a valve body with a first leg having a proximal port, a distal port and a lumen extending between the proximal port and the distal port, at least one valve being located in the lumen adjacent the proximal port to permit an interventional device to be passed therethrough, the valve body including a second leg extending at an angle relative to the first leg and in fluid communication with the first leg; an extension member having an extension member body with a proximal end and an opposing distal end, the extension member body including a hollow lumen extending therethrough from the proximal end to the distal end, wherein the extension member includes a rotating portion and the distal end of the hemostasis valve includes a non-rotational male luer connector; or the hemostasis valve includes a rotating male luer lock connector rotatably connected to the valve body proximate the distal port, wherein the extension member body has a female luer lock connector proximate the proximal end and a male luer lock connector proximate the distal end, the female luer lock connector of the extension member being removably secured to the male luer lock of the hemostasis valve at the proximal end of the extension member, the male luer lock connector of the extension member being configured to removably secure a guide catheter thereto, the extension member having a driven member configured to be rotatably driven by the drive member (58, 146), the drive member (58, 146) arranged to removably interface with the driven member while the guide catheter is secured to the extension member and the extension member is secured to the hemostasis valve, wherein the extension member interacts with the drive member (58, 146), the guide catheter and the hemostasis valve to impart rotation to the guide catheter while isolating the hemostasis valve from rotational motion; and a controller providing instructions to the motor via a user interface to rotate the drive member (58, 146), driven member, and extension member. a rotational drive motor coupled to a drive member (58, 146); a hemostasis valve including a valve body with a first leg having a proximal port, a distal port and a lumen extending between the proximal port and the distal port, at least one valve being located in the lumen adjacent the proximal port to permit an interventional device to be passed therethrough, the valve body including a second leg extending at an angle relative to the first leg and in fluid communication with the first leg; an extension member having an extension member body with a proximal end and an opposing distal end, the extension member body including a hollow lumen extending therethrough from the proximal end to the distal end, wherein the extension member includes a rotating portion and the distal end of the hemostasis valve includes a non-rotational male luer connector; or the hemostasis valve includes a rotating male luer lock connector rotatably connected to the valve body proximate the distal port, wherein the extension member body has a female luer lock connector proximate the proximal end and a male luer lock connector proximate the distal end, the female luer lock connector of the extension member being removably secured to the male luer lock of the hemostasis valve at the proximal end of the extension member, the male luer lock connector of the extension member being configured to removably secure a guide catheter thereto, the extension member having a driven member configured to be rotatably driven by the drive member (58, 146), the drive member (58, 146) arranged to removably interface with the driven member while the guide catheter is secured to the extension member and the extension member is secured to the hemostasis valve, wherein the extension member interacts with the drive member (58, 146), the guide catheter and the hemostasis valve to impart rotation to the guide catheter while isolating the hemostasis valve from rotational motion; and a controller providing instructions to the motor via a user interface to rotate the drive member (58, 146), driven member, and extension member.