A mold shuttle positioning system (10, 10') for positioning a hot glass sheet in multiple locations within a glass sheet heating and forming system comprising: a mold including a surface that defines a shape to which the glass sheet is to be initially formed; a mold support frame (16, 16') including at least one connection surface for mounting the mold thereon; a movable shuttle frame (20, 20') including a pair of generally parallel elongate beams (22, 24), each of the beams including a support surface (26, 28) near one end of the beam for receiving and supporting the mold support frame (16, 16') thereon; a drive mechanism for moving the shuttle frame in a generally horizontal direction; at least one mold guide mounted on the support surface of one of the beams (22, 24) for receiving the mold support frame (16, 16') and fixing the position of the mold support frame (16, 16') relative to the shuttle frame (20, 20') to prevent movement of the mold support frame (16, 16') with respect to the shuttle frame (20, 20') in any direction as the mold support frame (16, 16') is supported thereon, and at least one other mold guide mounted on the support surface of the other one of the beams (22, 24) for receiving the mold support frame (16, 16') and fixing the position of the mold support frame (16, 16') relative to the shuttle frame (20, 20') to prevent movement of the mold support frame (16, 16') in a first direction with respect to the shuttle frame, but allow movement of the mold support frame (16, 16') in a second direction with respect to the shuttle frame (20, 20') as the mold support frame (16, 16') is supported thereon; at least one support wheel assembly (30, 32) mounted to position and support each one of the beams (22, 24) as the shuttle frame (20, 20') is moved to position the mold at one of multiple desired processing locations, each support wheel assembly (30, 32) including a support wheel (34, 36) and an actuator for selectively moving the support wheel (34, 36) and the corresponding beam (22, 24) supported thereon in a generally vertical direction; and at least one shuttle guide mounted on at least one of the support wheel assemblies (30, 32) associated with only one of the beams (22, 24) for receiving the shuttle frame and fixing the position of the shuttle frame relative to the heating and forming system to locate and prevent movement of the shuttle frame in a first direction with respect to the heating and forming system, but allow movement of the shuttle frame in a second direction with respect to the heating and forming system as the shuttle frame and mold are positioned for processing the glass sheet in multiple locations within the heating and forming system. a mold including a surface that defines a shape to which the glass sheet is to be initially formed; a mold support frame (16, 16') including at least one connection surface for mounting the mold thereon; a movable shuttle frame (20, 20') including a pair of generally parallel elongate beams (22, 24), each of the beams including a support surface (26, 28) near one end of the beam for receiving and supporting the mold support frame (16, 16') thereon; a drive mechanism for moving the shuttle frame in a generally horizontal direction; at least one mold guide mounted on the support surface of one of the beams (22, 24) for receiving the mold support frame (16, 16') and fixing the position of the mold support frame (16, 16') relative to the shuttle frame (20, 20') to prevent movement of the mold support frame (16, 16') with respect to the shuttle frame (20, 20') in any direction as the mold support frame (16, 16') is supported thereon, and at least one other mold guide mounted on the support surface of the other one of the beams (22, 24) for receiving the mold support frame (16, 16') and fixing the position of the mold support frame (16, 16') relative to the shuttle frame (20, 20') to prevent movement of the mold support frame (16, 16') in a first direction with respect to the shuttle frame, but allow movement of the mold support frame (16, 16') in a second direction with respect to the shuttle frame (20, 20') as the mold support frame (16, 16') is supported thereon; at least one support wheel assembly (30, 32) mounted to position and support each one of the beams (22, 24) as the shuttle frame (20, 20') is moved to position the mold at one of multiple desired processing locations, each support wheel assembly (30, 32) including a support wheel (34, 36) and an actuator for selectively moving the support wheel (34, 36) and the corresponding beam (22, 24) supported thereon in a generally vertical direction; and at least one shuttle guide mounted on at least one of the support wheel assemblies (30, 32) associated with only one of the beams (22, 24) for receiving the shuttle frame and fixing the position of the shuttle frame relative to the heating and forming system to locate and prevent movement of the shuttle frame in a first direction with respect to the heating and forming system, but allow movement of the shuttle frame in a second direction with respect to the heating and forming system as the shuttle frame and mold are positioned for processing the glass sheet in multiple locations within the heating and forming system.