A sensor assembly (1, 1', 1") for an In-vitro diagnostic analyzer comprising - two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) with fluidic conduits (2, 3, 4) formed in between for receiving a sample; - a plurality of electrochemical sensors arranged on the two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) facing the fluidic conduits (2, 3, 4) for coming in contact with the sample and determining sample parameters, the plurality of electrochemical sensors being chosen from the groups of amperometric sensors, potentiometric sensors or combinations thereof; - wherein a potentiometric sensor comprises a potentiometric working electrode (12A, 12A') and a potentiometric reference electrode; - wherein an amperometric sensor comprises an amperometric working electrode and an amperometric counter reference electrode (ACRE) or an AWE and an amperometric reference electrode and an amperometric counter electrode; - wherein the PRE(s) and/or the ACRE(s) and/or the ARE(s) and the ACE(s) are formed on the same one of the two substrates (10A, 10B, 20A, 20B, 30A, 30B) and wherein the PWE(s) (12A, 12A') and/or the AWE(s) are formed on the opposite one of the two substrates (10A, 10B, 20A, 20B, 30A, 30B); - characterized in that the potentiometric sensors and/or amperometric sensors have different susceptibility to deterioration through a system fluid, wherein the potentiometric sensors and/or the amperometric sensors with a higher susceptibility to deterioration are arranged along a first fluidic conduit and the potentiometric sensors and/or amperometric sensors with a lower susceptibility to deterioration are arranged along a fluidic conduit different from the first fluidic conduit. - two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) with fluidic conduits (2, 3, 4) formed in between for receiving a sample; - a plurality of electrochemical sensors arranged on the two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) facing the fluidic conduits (2, 3, 4) for coming in contact with the sample and determining sample parameters, the plurality of electrochemical sensors being chosen from the groups of amperometric sensors, potentiometric sensors or combinations thereof; - wherein a potentiometric sensor comprises a potentiometric working electrode (12A, 12A') and a potentiometric reference electrode; - wherein an amperometric sensor comprises an amperometric working electrode and an amperometric counter reference electrode (ACRE) or an AWE and an amperometric reference electrode and an amperometric counter electrode; - wherein the PRE(s) and/or the ACRE(s) and/or the ARE(s) and the ACE(s) are formed on the same one of the two substrates (10A, 10B, 20A, 20B, 30A, 30B) and wherein the PWE(s) (12A, 12A') and/or the AWE(s) are formed on the opposite one of the two substrates (10A, 10B, 20A, 20B, 30A, 30B); - characterized in that the potentiometric sensors and/or amperometric sensors have different susceptibility to deterioration through a system fluid, wherein the potentiometric sensors and/or the amperometric sensors with a higher susceptibility to deterioration are arranged along a first fluidic conduit and the potentiometric sensors and/or amperometric sensors with a lower susceptibility to deterioration are arranged along a fluidic conduit different from the first fluidic conduit.