Panel processing machine comprising: - a support structure; - a set of jig elements for the panels assigned to orient the panels almost horizontally while maintaining an upper or lower face thereof at respective predetermined heights (Z, Z'); - at least a set of first movement members and a set of second movement members translating in both directions respectively along at least one first longitudinal track and at least one second longitudinal track connected to the support structure and oriented in the longitudinal direction for moving the panels along a path between an entrance and an exit for said panels parallel to the longitudinal direction; - at least one upper and/or lower working head positioned respectively above or below a processing area lying along said path, said at least one working head (25, 27) provided with at least one tool for processing the panels, with the at least one working head (25, 27) and/or its respective at least one tool operable at least in the vertical direction by a respective vertical actuator; each movement member (11, 13) comprises at least one respective grab element, each grab element being operable to lock and release at least one panel by effect of a respective grab actuator; each grab element is movable in at least one direction other than the longitudinal direction by means of a respective positioning actuator; each movement member (11, 13) comprises a carriage slidably fixed to its respective longitudinal track (15,17), where each positioning actuator is interposed between its respective carriage and one or more grab elements; the at least one first longitudinal track and the at least one second longitudinal track are fixed on the same longitudinal side of the machine, with their respective sets of movement members (11, 13) operating along the path of the panels between the entrance and the exit; at least one grab element is operated with respect to its corresponding carriage in a direction perpendicular to the longitudinal direction at least in correspondence with the intersection with the trajectory of a grab element of a different set of movement members (11, 13); the machine being characterized in that each grab element not carrying any panel is operated in the vertical direction at least in correspondence with the intersection with the trajectory of a grab element carrying a panel, and/or in that each grab element carrying at least one panel is operated in the transverse direction at least in correspondence with the intersection with the trajectory of a grab element carrying no panel. - a support structure; - a set of jig elements for the panels assigned to orient the panels almost horizontally while maintaining an upper or lower face thereof at respective predetermined heights (Z, Z'); - at least a set of first movement members and a set of second movement members translating in both directions respectively along at least one first longitudinal track and at least one second longitudinal track connected to the support structure and oriented in the longitudinal direction for moving the panels along a path between an entrance and an exit for said panels parallel to the longitudinal direction; - at least one upper and/or lower working head positioned respectively above or below a processing area lying along said path, said at least one working head (25, 27) provided with at least one tool for processing the panels, with the at least one working head (25, 27) and/or its respective at least one tool operable at least in the vertical direction by a respective vertical actuator; each movement member (11, 13) comprises at least one respective grab element, each grab element being operable to lock and release at least one panel by effect of a respective grab actuator; each grab element is movable in at least one direction other than the longitudinal direction by means of a respective positioning actuator; each movement member (11, 13) comprises a carriage slidably fixed to its respective longitudinal track (15,17), where each positioning actuator is interposed between its respective carriage and one or more grab elements; the at least one first longitudinal track and the at least one second longitudinal track are fixed on the same longitudinal side of the machine, with their respective sets of movement members (11, 13) operating along the path of the panels between the entrance and the exit; at least one grab element is operated with respect to its corresponding carriage in a direction perpendicular to the longitudinal direction at least in correspondence with the intersection with the trajectory of a grab element of a different set of movement members (11, 13); the machine being characterized in that each grab element not carrying any panel is operated in the vertical direction at least in correspondence with the intersection with the trajectory of a grab element carrying a panel, and/or in that each grab element carrying at least one panel is operated in the transverse direction at least in correspondence with the intersection with the trajectory of a grab element carrying no panel.