An X-ray system (100, 400, 800, or 1200), comprising an X-ray source (111, 411, 820, or 1231) configured to emit an X-ray beam towards a target subject; a detection component (112, 412, 810, or 1232) configured to receive at least a portion of the X-ray beam that transmits through the target subject; an arm (113, 410, 830, or 1230) configured to support the detection component (112, 412, 810, or 1232) and the X-ray source (111, 411, 820, or 1231); a platform (114 or 1250) configured to place the target subject, the platform (114 or 1250) being situated between the X-ray source (111, 411, 820, or 1231) and the detection component (112, 412, 810, or 1232); a laser emitting component mounted on the x-ray source and configured to emit a laser beam with a first pattern on the target subject, wherein the first pattern includes grids; and a positioning component being situated between the detection component (112, 412, 810, or 1232) and the platform (114 or 1250), wherein the positioning component has a second pattern including grids, and wherein the first pattern being projected on the positioning component coincides with the pattern of the positioning component, and the positioning component and the laser emitting component are configured to locate a target point corresponding to a lesion point associated with the target subject based on the first pattern projected on a surface of the target subject and an overlaid image, wherein the overlaid image includes an anatomical image associated with the target subject determined by projecting the X-ray beam towards the target subject and the pattern of the positioning component. an X-ray source (111, 411, 820, or 1231) configured to emit an X-ray beam towards a target subject; a detection component (112, 412, 810, or 1232) configured to receive at least a portion of the X-ray beam that transmits through the target subject; an arm (113, 410, 830, or 1230) configured to support the detection component (112, 412, 810, or 1232) and the X-ray source (111, 411, 820, or 1231); a platform (114 or 1250) configured to place the target subject, the platform (114 or 1250) being situated between the X-ray source (111, 411, 820, or 1231) and the detection component (112, 412, 810, or 1232); a laser emitting component mounted on the x-ray source and configured to emit a laser beam with a first pattern on the target subject, wherein the first pattern includes grids; and a positioning component being situated between the detection component (112, 412, 810, or 1232) and the platform (114 or 1250), wherein the positioning component has a second pattern including grids, and wherein the first pattern being projected on the positioning component coincides with the pattern of the positioning component, and the positioning component and the laser emitting component are configured to locate a target point corresponding to a lesion point associated with the target subject based on the first pattern projected on a surface of the target subject and an overlaid image, wherein the overlaid image includes an anatomical image associated with the target subject determined by projecting the X-ray beam towards the target subject and the pattern of the positioning component.