mhurhangee/ep-ind-claims huggingface dataset:
A combination of a WEE1 inhibitor and a CHK1 inhibitor for use in treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer, and ovarian cancer, wherein the WEE1 inhibitor is 2-allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6- {[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one (MK-1775) or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is -(-)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-piperidin-3-yl-pyrazolo[1,5-a]pyrimidin-7-ylamine (MK-8776) or a pharmaceutically acceptable salt thereof.
A battery assembly, comprising: at least one insulated element defining an installation space; at least one battery detachably inserted into the installation space; and a shell defining a receiving space for receiving the at least one insulated element and the at least one battery inserted into the insulated element, and the at least one battery being prevented from contacting with the shell by the at least one insulated element, wherein the shell further comprises at least one securing element configured for fixing the at least one insulated element on the shell; characterized in that the at least one securing element is an adhesive article. at least one insulated element defining an installation space; at least one battery detachably inserted into the installation space; and a shell defining a receiving space for receiving the at least one insulated element and the at least one battery inserted into the insulated element, and the at least one battery being prevented from contacting with the shell by the at least one insulated element, wherein the shell further comprises at least one securing element configured for fixing the at least one insulated element on the shell; characterized in that the at least one securing element is an adhesive article.
A frame load-bearing structure, preferably a chassis, for a commercial vehicle, preferably a lorry, having - at least one receiving container with at least one commercial vehicle component, namely a battery, - two longitudinal carrier structures, - at least one rear axle for the commercial vehicle, and - an end crossmember which is arranged behind the rear axle, - the receiving container being arranged behind the rear axle, characterized in that - the frame load-bearing structure is provided with a crash protection structure which protects the receiving container against an impact, and the crash protection structure comprises a crossmember element (4.1) which extends in the transverse direction of the frame load-bearing structure, runs behind the receiving container, and is arranged at least in sections below the level of the end crossmember, and - the end crossmember is provided with two side arm structures which are connected to the two longitudinal carrier structures and act as an extension of the longitudinal carrier structures, and the end crossmember, the side arm structures and the crash protection structure form one structural unit. - at least one receiving container with at least one commercial vehicle component, namely a battery, - two longitudinal carrier structures, - at least one rear axle for the commercial vehicle, and - an end crossmember which is arranged behind the rear axle, - the receiving container being arranged behind the rear axle, - the frame load-bearing structure is provided with a crash protection structure which protects the receiving container against an impact, and the crash protection structure comprises a crossmember element (4.1) which extends in the transverse direction of the frame load-bearing structure, runs behind the receiving container, and is arranged at least in sections below the level of the end crossmember, and - the end crossmember is provided with two side arm structures which are connected to the two longitudinal carrier structures and act as an extension of the longitudinal carrier structures, and the end crossmember, the side arm structures and the crash protection structure form one structural unit.
A selective laser solidification apparatus, comprising; build platform (102, 302) for supporting a powder bed (104, 304) onto which powder layers can be deposited, at least one laser module (1, 2, 3, 4) for generating a plurality of laser beams for solidifying the powder material deposited onto the powder bed (104, 304), a laser scanner (106a, 106b, 106c, 106d, 306a, 306b, 306c, 306d, 306e) for individually steering each laser beam to solidify separate areas in each powder layer, a scanning zone (1a, 2a, 3a, 4a, 201a, 201b, 201c, 201d, 301a, 301b, 301c, 301d, 301e) for each laser beam defined by the locations on the powder bed (104, 304) to which the laser beam can be steered by the laser scanner (106a, 106b, 106c, 106d, 306a, 306b, 306c, 306d, 306e), the laser scanner (106a, 106b, 106c, 106d, 306a, 306b, 306c, 306d, 306e) arranged such that each scanning zone (1a, 2a, 3a, 4a, 201a, 201b, 201c, 201d, 301a, 301b, 301c, 301d, 301e) is less than the total area of the powder bed (104, 304) and at least two of the scanning zones (1a, 2a, 3a, 4a, 201a, 201b, 201c, 201d, 301a, 301b, 301c, 301d, 301e) overlap, and a processing unit, characterised in that, the processing unit is arranged to select, for at least one of the powder layers, which one of the laser beams to use to solidify an area of the powder layer located within a region (211, 213, 215, 217, 218) in which the scanning zones (1a, 2a, 3a, 4a, 201a, 201b, 201c, 201d, 301a, 301b, 301c, 301d, 301e) overlap to reduce periods of non-utilisation of the laser beams.
A method of cutting sapphire comprising a sapphire body and a coating formed on the sapphire body, the method comprising: focusing a first CO 2 laser beam on the coating via a CO 2 focusing assembly to remove the coating with a predetermined thickness extending along a first path; wherein dust and debris generated during removal of the coating are removed while the coating is removed; focusing an ultrafast laser beam on the sapphire body via an optical path shaping assembly to form a plurality of restructuring channels distributed along a second path and penetrating through the sapphire; wherein the second path coincides with the first path; and scanning, by a second CO 2 laser beam, the sapphire body via a galvanometer focusing assembly, wherein a path of the second CO 2 laser beam scanning the sapphire body via a galvanometer focusing assembly coincides with or deviates from the second path, so that the sapphire cracks along the restructuring channels. focusing a first CO 2 laser beam on the coating via a CO 2 focusing assembly to remove the coating with a predetermined thickness extending along a first path; wherein dust and debris generated during removal of the coating are removed while the coating is removed; focusing an ultrafast laser beam on the sapphire body via an optical path shaping assembly to form a plurality of restructuring channels distributed along a second path and penetrating through the sapphire; wherein the second path coincides with the first path; and scanning, by a second CO 2 laser beam, the sapphire body via a galvanometer focusing assembly, wherein a path of the second CO 2 laser beam scanning the sapphire body via a galvanometer focusing assembly coincides with or deviates from the second path, so that the sapphire cracks along the restructuring channels.
A storage device comprising: a receptacle; and a movable closure member; the closure member comprising a seal about its periphery, for positioning against the inside of the receptacle, and a valve within its periphery, wherein the closure member can be moved within the receptacle such that its periphery is substantially continually in contact with the internal surface of the receptacle, and wherein, when in an open position, the valve allows flow of fluid from within the receptacle through the valve, and when in a closed position, the valve prevents flow of liquid from within the receptacle, wherein the receptacle is closed at its lower end, wherein the movable closure member comprises an aperture and the valve comprises a blocking member that, in a closed position, is received within the aperture and closes the aperture to the passage of fluid and the blocking member comprises a float that, when it comes into contact with liquid contained within the receptacle, floats thereupon and blocks the aperture of the closure member, wherein the closure member comprises an adjustment section for adjusting the position of the closure member within the receptacle and the adjustment section comprises a conduit therethrough, characterized in that the conduit allows fluid communication from within the receptacle, through the valve and through the adjustment section to the outside of the device. a receptacle; and a movable closure member; wherein the closure member comprises an adjustment section for adjusting the position of the closure member within the receptacle and the adjustment section comprises a conduit therethrough, characterized in that the conduit allows fluid communication from within the receptacle, through the valve and through the adjustment section to the outside of the device.
Work vehicle having a first pair of wheels mounted to a vehicle body via a fixed axle and a second pair of wheels mounted to said vehicle body via a pivotable axle, the vehicle comprising axle housings close to each wheel and an anti-rollover system comprising at least two load sensor means, wherein one sensor mean is mounted at the upper side and the other sensor mean is mounted at lower side of the axle housing of the first pair of wheels, to measure a downward force borne by the respective wheel, the load sensor means being operationally connected to a processor, wherein the processor is configured to send anti-rollover commands to the anti-rollover system, based on signals received from said at least two load sensor means, whereby the load sensor means comprise at least one strain gauge (22, 23, 24, 25, 26, 27).
A battery control system connected to a battery equipped with an explosion-proofing mechanism, said explosion-proofing mechanism being adapted to cut off an electric current when the battery enters an overcharge state, the battery control system being adapted to control a state of charge of the battery cells, and comprising: a cell voltage detection unit for detecting a cell voltage at the battery; a storage unit for storing information pertaining to the state of charge of the battery; an overcharge decision-making unit for making a decision as to whether or not the battery is in an overcharge state; a storage control unit for engaging the storage unit to store overcharge information pertaining to the overcharge state at the battery when the overcharge decision-making unit decides that the battery is in an overcharge state; characterized by an explosion-proofing decision-making unit for deciding at startup of the battery control system that the explosion-proofing mechanism in the battery has actuated if the overcharge information is stored in the storage unit and the cell voltage detected by the cell voltage detection unit is lower than a predetermined lower limit value. a cell voltage detection unit for detecting a cell voltage at the battery; a storage unit for storing information pertaining to the state of charge of the battery; an overcharge decision-making unit for making a decision as to whether or not the battery is in an overcharge state; a storage control unit for engaging the storage unit to store overcharge information pertaining to the overcharge state at the battery when the overcharge decision-making unit decides that the battery is in an overcharge state; characterized by an explosion-proofing decision-making unit for deciding at startup of the battery control system that the explosion-proofing mechanism in the battery has actuated if the overcharge information is stored in the storage unit and the cell voltage detected by the cell voltage detection unit is lower than a predetermined lower limit value.
A pressure monitoring cushion comprising first and second pressure sensors, a controller configured to receive input from the pressure sensors, output means (36, 38) controlled by the controller, and a power source, wherein each pressure sensor includes first and second electrical conductors (18, 20, 24) and a resilient electrical insulator (22, 26) disposed between the electrical conductors (18, 20, 24); each electrical insulator (22, 26) includes one or more apertures (28, 30) through which the adjacent electrical conductors (18, 20, 24) come into contact when a threshold pressure is applied to the cushion; the electrical conductors (18, 20) of the first pressure sensor come into contact at a first threshold pressure, and the electrical conductors (20, 24) of the second pressure sensor come into contact at a higher second threshold pressure; and the controller triggers an output from the output means (36, 38) after a predetermined period of time has elapsed with contact between the electrical conductors (18, 20, 24) in the first and/or second pressure sensors; characterised in that the controller shortens the period of time until the output means (36, 38) is triggered when the second pressure sensor detects the second threshold pressure. each pressure sensor includes first and second electrical conductors (18, 20, 24) and a resilient electrical insulator (22, 26) disposed between the electrical conductors (18, 20, 24); each electrical insulator (22, 26) includes one or more apertures (28, 30) through which the adjacent electrical conductors (18, 20, 24) come into contact when a threshold pressure is applied to the cushion; the electrical conductors (18, 20) of the first pressure sensor come into contact at a first threshold pressure, and the electrical conductors (20, 24) of the second pressure sensor come into contact at a higher second threshold pressure; and the controller triggers an output from the output means (36, 38) after a predetermined period of time has elapsed with contact between the electrical conductors (18, 20, 24) in the first and/or second pressure sensors; characterised in that the controller shortens the period of time until the output means (36, 38) is triggered when the second pressure sensor detects the second threshold pressure.
A method for determining of at least one of CD4+ T-cell lymphocytes count, CD8+ T-cell lymphocytes count, or total lymphocytes count in a biological fluid sample, the method comprising the steps of: (a) adding to said biological fluid sample a sole antibody specific to anyone of said respective lymphocytes, said sole antibody conjugated with an optically detectable marker, said sole antibody is selected from the group consisting of an anti-CD4 antibody for determination of said CD4+ T-cell lymphocytes count, anti-CD8 antibody for determination of said CD8+ T-cell lymphocytes count, and an anti-CD45 antibody for determination of said total lymphocytes count; (b) incubating said biological fluid sample mixture of step (a) for duration from 5 min to 60 min and at a temperature ranging from 20 degrees Celsius to 37 degrees Celsius; (c) filtering said biological fluid sample mixture through a leukocyte-reduction retainer filter, said filter is configured for capturing thereon of said leukocytes including those which bound to said antibody of said biological fluid sample mixture, said filter is further configured for all captured leukocytes to contain at least 80 percent or more lymphocytes and at least 20 percent or less of any other subsets of leukocytes; (d) washing said leukocyte-reduction retainer filter to remove weakly-bound substances; and (e) optically detecting said bound antibody conjugated to said optically detectable marker which is retained on said leukocyte-reduction retainer filter in step (c) for determining of said at least one respective CD4+ T-cell lymphocytes count, CD8+ T-cell lymphocytes count, or total lymphocytes in said biological fluid. (a) adding to said biological fluid sample a sole antibody specific to anyone of said respective lymphocytes, said sole antibody conjugated with an optically detectable marker, said sole antibody is selected from the group consisting of an anti-CD4 antibody for determination of said CD4+ T-cell lymphocytes count, anti-CD8 antibody for determination of said CD8+ T-cell lymphocytes count, and an anti-CD45 antibody for determination of said total lymphocytes count; (b) incubating said biological fluid sample mixture of step (a) for duration from 5 min to 60 min and at a temperature ranging from 20 degrees Celsius to 37 degrees Celsius; (c) filtering said biological fluid sample mixture through a leukocyte-reduction retainer filter, said filter is configured for capturing thereon of said leukocytes including those which bound to said antibody of said biological fluid sample mixture, said filter is further configured for all captured leukocytes to contain at least 80 percent or more lymphocytes and at least 20 percent or less of any other subsets of leukocytes; (d) washing said leukocyte-reduction retainer filter to remove weakly-bound substances; and (e) optically detecting said bound antibody conjugated to said optically detectable marker which is retained on said leukocyte-reduction retainer filter in step (c) for determining of said at least one respective CD4+ T-cell lymphocytes count, CD8+ T-cell lymphocytes count, or total lymphocytes in said biological fluid.
Method for manufacturing plastic labels with a self-adhesive pattern, and attaching such labels such that they are enfolding a can, whereby it comprises the step of overlapping a side edge of the label by another part of the label after attaching said label such that it is enfolding a can, and that it comprises at least the following steps: - Printing a plastic foil in the form of an elongated strip using a digital printing technique, whereby successively along the lengthwise direction (L') of the strip prints are being printed corresponding to a label, whereby the prints follow each other in the lengthwise direction (L') of the strip, and whereby the side edges of consecutive label prints on the strip are situated at right angles, along the direction crosswise to the lengthwise direction (L') of the strip; - Applying adhesive on the plastic foil, either on the whole surface of the plastic foil, or on only a part of it, forming a self-adhesive plastic foil; - Enfolding a can by means of a free end of the plastic foil with a length at least corresponding to the circumference of the can, or the like, whereby, after enfolding, an aforementioned side edge of a label print is overlapped by another part of the plastic foil and whereby the part of the foil that is enfolding the can adheres to the can by means of said adhesive; and, - Cutting off the concerning part of the plastic foil corresponding to the length of a label; characterized in that the label is cut off at a certain distance from the overlapping part and the side edge of the plastic foil, providing a flap at the label. - Printing a plastic foil in the form of an elongated strip using a digital printing technique, whereby successively along the lengthwise direction (L') of the strip prints are being printed corresponding to a label, whereby the prints follow each other in the lengthwise direction (L') of the strip, and whereby the side edges of consecutive label prints on the strip are situated at right angles, along the direction crosswise to the lengthwise direction (L') of the strip; - Applying adhesive on the plastic foil, either on the whole surface of the plastic foil, or on only a part of it, forming a self-adhesive plastic foil; - Enfolding a can by means of a free end of the plastic foil with a length at least corresponding to the circumference of the can, or the like, whereby, after enfolding, an aforementioned side edge of a label print is overlapped by another part of the plastic foil and whereby the part of the foil that is enfolding the can adheres to the can by means of said adhesive; and, - Cutting off the concerning part of the plastic foil corresponding to the length of a label; characterized in that the label is cut off at a certain distance from the overlapping part and the side edge of the plastic foil, providing a flap at the label.
A threaded member tightening tool (1; 101) comprising: a tool body (10; 110) having an engaging element fitting unit (18; 118) to which a threaded member engaging element (12; 112) is to be fitted, and an electric motor rotationally driving the engaging element fitting unit (18; 118); and a forward-reverse rotation switching unit (14; 114) for switching a direction of rotation of the engaging element fitting unit (18; 118) by the electric motor between a forward direction and a reverse direction; characterized by a computing unit switchable between a counting mode in which the computing unit counts a number of threaded members tightened with the tool body and holds the counted number as a count value and a count return mode for returning the count value to a one-preceding count value; and a mode switching unit (36; 136) for switching the computing unit from the counting mode to the count return mode; wherein the computing unit is configured to return the count value to a one-preceding count value based on a fact that the engaging element fitting unit (18; 118) has been driven in the reverse direction when the computing unit has been switched to the count return mode. a tool body (10; 110) having an engaging element fitting unit (18; 118) to which a threaded member engaging element (12; 112) is to be fitted, and an electric motor rotationally driving the engaging element fitting unit (18; 118); and a forward-reverse rotation switching unit (14; 114) for switching a direction of rotation of the engaging element fitting unit (18; 118) by the electric motor between a forward direction and a reverse direction; characterized by a computing unit switchable between a counting mode in which the computing unit counts a number of threaded members tightened with the tool body and holds the counted number as a count value and a count return mode for returning the count value to a one-preceding count value; and a mode switching unit (36; 136) for switching the computing unit from the counting mode to the count return mode; wherein the computing unit is configured to return the count value to a one-preceding count value based on a fact that the engaging element fitting unit (18; 118) has been driven in the reverse direction when the computing unit has been switched to the count return mode.
Housing for a galvanic cell, in particular a lithium-ion cell, or for a battery module made up of a number of galvanic cells or for a battery pack of a number of battery modules comprising galvanic cells, comprising - a main housing with an opening for introducing the device(s) to be housed, for example a lithium-ion cell, into the main housing and with at least one side wall bounding the opening, - a housing cover, - at least one electrically insulating insulation layer, and - at least one electrically insulating cover strip, the opening of the main housing being closed by the housing cover, the housing cover being connected to the side wall or side walls of the main housing, the insulation layer covering at least one of the outer surfaces (S, B) of the main housing and/or of the housing cover, at least the connecting region between the housing cover and the side wall or side walls being covered by the cover strip, the housing cover being connected to the side wall or the side walls of the main housing by a weld seam and the electrically insulating cover strip covering the weld seam and also the portions adjoining thereto of the insulation layer. - a main housing with an opening for introducing the device(s) to be housed, for example a lithium-ion cell, into the main housing and with at least one side wall bounding the opening, - a housing cover, - at least one electrically insulating insulation layer, and - at least one electrically insulating cover strip,