mhurhangee/ep-ind-claims huggingface dataset:
An injectable paliperidone palmitate depot for use in a method of treating a patient in need of psychiatric treatment for psychosis, schizophrenia, or bipolar disorder that has been treated with a 3-month paliperidone palmitate extended-release injectable suspension, wherein greater than or equal to 4 months and up to nine months have elapsed since the last injection of 3-month paliperidone palmitate extended-release injectable suspension, by a dosing regimen comprising: administering intramuscularly in the deltoid muscle of said patient a first reinitiation loading dose of a 1-month paliperidone palmitate extended-release injectable suspension; administering intramuscularly in the deltoid muscle of said patient a second reinitiation loading dose of a 1-month paliperidone palmitate extended-release injectable suspension on about the 4th day to about the 12th day after administering said first reinitiation loading dose; and administering intramuscularly in the deltoid or gluteal muscle of said patient a reinitiation 3-month paliperidone palmitate extended-release injectable suspension in the range of about 175mg eq. to about 525 mg eq. on about the 23rd day to about the 37th day after administering the second reinitiation loading dose of monthly injectable paliperidone palmitate wherein said first and second reinitiation loading dose and the reinitiation 3-month formulation of paliperidone palmitate dose are selected from the table below based on the amount of the missed dose Missed PP3M dose Administer PP1M, two doses (into deltoid muscle) Then administer PP3M (into deltoid or gluteal muscle) First Reinitation Dose Second Reinitation Dose Reinitiation 3-month formulation Dose 175 mg eq. 50 mg eq. 50 mg eq. 175 mg eq. 263 mg eq. 75 mg eq. 75 mg eq. 263 mg eq. 350 mg eq. 100 mg eq. 100 mg eq. 350 mg eq. 525 mg eq. 100 mg eq. 100 mg eq. 525 mg eq. administering intramuscularly in the deltoid muscle of said patient a first reinitiation loading dose of a 1-month paliperidone palmitate extended-release injectable suspension; administering intramuscularly in the deltoid muscle of said patient a second reinitiation loading dose of a 1-month paliperidone palmitate extended-release injectable suspension on about the 4th day to about the 12th day after administering said first reinitiation loading dose; and administering intramuscularly in the deltoid or gluteal muscle of said patient a reinitiation 3-month paliperidone palmitate extended-release injectable suspension in the range of about 175mg eq. to about 525 mg eq. on about the 23rd day to about the 37th day after administering the second reinitiation loading dose of monthly injectable paliperidone palmitate
Implant injection device, characterised in that it comprises: - an injection needle, - a receiver housing for receiving at least a first implant and a second implant, - injection means, comprising:. a pushing rod, arranged upstream from said implants housed in the receiver housing and configured to push the first implant and the second implant through the injection needle between an initial position and a final position in which the first implant and the second implant are injected,. means for pushing on the pushing rod, configured to exert a force tending to move the pushing rod from the initial position to the final position,. intermediate stop means holding the pushing rod in an intermediate position between the initial position and the final position, said means oppose the force exerted by the pushing means when the stroke of the pushing rod reaches a predetermined distance corresponding to the length of injection of the first implant,. means for actuation by a user, configured to release a displacement of the pushing rod from the intermediate position to the final position. - an injection needle, - a receiver housing for receiving at least a first implant and a second implant, - injection means, comprising:. a pushing rod, arranged upstream from said implants housed in the receiver housing and configured to push the first implant and the second implant through the injection needle between an initial position and a final position in which the first implant and the second implant are injected,. means for pushing on the pushing rod, configured to exert a force tending to move the pushing rod from the initial position to the final position,. intermediate stop means holding the pushing rod in an intermediate position between the initial position and the final position, said means oppose the force exerted by the pushing means when the stroke of the pushing rod reaches a predetermined distance corresponding to the length of injection of the first implant,. means for actuation by a user, configured to release a displacement of the pushing rod from the intermediate position to the final position.. a pushing rod, arranged upstream from said implants housed in the receiver housing and configured to push the first implant and the second implant through the injection needle between an initial position and a final position in which the first implant and the second implant are injected,. means for pushing on the pushing rod, configured to exert a force tending to move the pushing rod from the initial position to the final position,. intermediate stop means holding the pushing rod in an intermediate position between the initial position and the final position, said means oppose the force exerted by the pushing means when the stroke of the pushing rod reaches a predetermined distance corresponding to the length of injection of the first implant,. means for actuation by a user, configured to release a displacement of the pushing rod from the intermediate position to the final position.
An electrocardiogram measurement system comprising: a patch-type electrocardiogram measurement apparatus; a first device configured to receive first electrocardiogram data and measured time information from an electrocardiogram measurement apparatus by means of a first communication method and configured to store the first electrocardiogram data measured by the electrocardiogram measurement apparatus for first time period; and a second device configured to receive second electrocardiogram data and measured time information from the electrocardiogram measurement apparatus by means of the first communication method and store the second electrocardiogram data measured by the electrocardiogram measurement apparatus for second time period, wherein the first time period and the second time period are at least partially at different times, characterised in that the second device is automatically connected to the electrocardiogram measurement apparatus when the connection of the first device with the electrocardiogram measurement apparatus is released, and the first device is configured to receive the second electrocardiogram data from the second device via the second communication unit, store the second electrocardiogram data, and generate combined data by combining the first electrocardiogram data and the second electrocardiogram data using measured time information included the first and the second electrocardiogram data. a patch-type electrocardiogram measurement apparatus; a first device configured to receive first electrocardiogram data and measured time information from an electrocardiogram measurement apparatus by means of a first communication method and configured to store the first electrocardiogram data measured by the electrocardiogram measurement apparatus for first time period; and a second device configured to receive second electrocardiogram data and measured time information from the electrocardiogram measurement apparatus by means of the first communication method and store the second electrocardiogram data measured by the electrocardiogram measurement apparatus for second time period, wherein the first time period and the second time period are at least partially at different times, characterised in that the second device is automatically connected to the electrocardiogram measurement apparatus when the connection of the first device with the electrocardiogram measurement apparatus is released, and the first device is configured to receive the second electrocardiogram data from the second device via the second communication unit, store the second electrocardiogram data, and generate combined data by combining the first electrocardiogram data and the second electrocardiogram data using measured time information included the first and the second electrocardiogram data.
Leak test for a flexible pouch specifically designed to contain a biopharmaceutical fluid, wherein - the flexible pouch is sandwiched between two plates (40, 42; 12A, 12B) which have each an internal surface able to allow gas which escape from a hole on the flexible pouch flowing out of an external surface of the flexible pouch, the two plates (40, 42; 12A, 12B) forming a substantially planar protecting body with the external surfaces of the flexible pouch in touch with the internal surfaces of the two plates, wherein the protective body comprises a longitudinal direction, two longitudinal sides and two transversal sides, the two plates being fixed to each other by an attachment system that is symmetrically arranged on at least two sides of the two plates, the attachment system comprising at least one snap button, one of the two plates comprising a first element of the snap button and the other one of the two plates comprising a second complementary element of the snap button, and wherein the leak test then comprises: - introducing a gas within the sandwiched flexible pouch by means of a pump linked to an inlet of the flexible pouch by means of a hose, the two plates being flexible enough to allow the protecting body to have a thickness in a central area greater than in a circumferential area, in reference to the plane of the protecting body, and - measuring the pressure within the flexible pouch - the flexible pouch is sandwiched between two plates (40, 42; 12A, 12B) which have each an internal surface able to allow gas which escape from a hole on the flexible pouch flowing out of an external surface of the flexible pouch, the two plates (40, 42; 12A, 12B) forming a substantially planar protecting body with the external surfaces of the flexible pouch in touch with the internal surfaces of the two plates, wherein the protective body comprises a longitudinal direction, two longitudinal sides and two transversal sides, the two plates being fixed to each other by an attachment system that is symmetrically arranged on at least two sides of the two plates, the attachment system comprising at least one snap button, one of the two plates comprising a first element of the snap button and the other one of the two plates comprising a second complementary element of the snap button, and wherein the leak test then comprises: - introducing a gas within the sandwiched flexible pouch by means of a pump linked to an inlet of the flexible pouch by means of a hose, the two plates being flexible enough to allow the protecting body to have a thickness in a central area greater than in a circumferential area, in reference to the plane of the protecting body, and - measuring the pressure within the flexible pouch - introducing a gas within the sandwiched flexible pouch by means of a pump linked to an inlet of the flexible pouch by means of a hose, the two plates being flexible enough to allow the protecting body to have a thickness in a central area greater than in a circumferential area, in reference to the plane of the protecting body, and - measuring the pressure within the flexible pouch
Prosthesis for small bones, in particular a trapezio-metacarpal or interphalangeal prosthesis, comprising at least one elongated bone implant formed by assembling a medullary element with a bent proximal portion and a joint element, characterized in that said medullary element has a gripping groove arranged at the proximal portion thereof.
A cavity system, comprising: a cavity and a plurality of rods; the rods extending in a direction away from a base of the cavity to a height that extends beyond the height of a leading edge of the cavity, the leading edge being relative to an actual or intended flow direction of a fluid over the cavity; the rods being positioned downstream of, and in the proximity of, the leading edge of the cavity wherein one or more flow alteration elements (34, 38) are provided on one or more of the rods, characterised in that: at least some of the flow alteration elements (34, 38) comprise or provide additional edges at the one or more rods that are in addition to the edge or edges provided by the underlying shape of the rod or rods. a cavity and a plurality of rods; the rods extending in a direction away from a base of the cavity to a height that extends beyond the height of a leading edge of the cavity, the leading edge being relative to an actual or intended flow direction of a fluid over the cavity; the rods being positioned downstream of, and in the proximity of, the leading edge of the cavity wherein one or more flow alteration elements (34, 38) are provided on one or more of the rods, characterised in that: at least some of the flow alteration elements (34, 38) comprise or provide additional edges at the one or more rods that are in addition to the edge or edges provided by the underlying shape of the rod or rods. at least some of the flow alteration elements (34, 38) comprise or provide additional edges at the one or more rods that are in addition to the edge or edges provided by the underlying shape of the rod or rods.
An adiponectin receptor agonist for use in treating depression, anxiety or a neuroinflammatory disorder in a patient, wherein the adiponectin receptor agonist is a compound of the following formula: wherein: A represents a phenyl group optionally substituted with an halogen atom or a methyl group, Y 1 represents - (CHR 2) a -, wherein R 2 represents H or a methyl group and a represents 1; > X is CH; R 1 represents a C 1-7 alkyl group with m representing 0; Y 2 represents *-O-CH 2 -CONH;; Z represents a phenyl group n represents -CO-R 4 or -O-R 4, wherein R 4 is chosen from: • a phenyl group optionally substituted with a halogen atom, or • a pyridyl group optionally substituted with a halogen atom, and; n represents 1. A represents a phenyl group optionally substituted with an halogen atom or a methyl group, Y 1 represents - (CHR 2) a -, wherein R 2 represents H or a methyl group and a represents 1; > X is CH; R 1 represents a C 1-7 alkyl group with m representing 0; Y 2 represents *-O-CH 2 -CONH;; Z represents a phenyl group n represents -CO-R 4 or -O-R 4, wherein R 4 is chosen from: • a phenyl group optionally substituted with a halogen atom, or • a pyridyl group optionally substituted with a halogen atom, and; n represents 1. • a phenyl group optionally substituted with a halogen atom, or • a pyridyl group optionally substituted with a halogen atom, and; n represents 1.
Therapy appliance for use in administering medication by nasal inhalation, comprising a breathing tube, to the end of which a nasal applicator is connected and to the input end of which a number of medication containers and an aerosol generator are connected, and comprising a control unit which activates the aerosol generator according to a predetermined activation pattern, characterised in that the control unit limits the inhalation flow during the supply of aerosol particles to at most 500 ml/s and sets the inhalation volume to at least 0.3 I.
Detector having a sensor for the substantially high fidelity recording of a chronological progression of the at least one electrical parameter, wherein the detector is configured for the detection of aperiodic, substantially sudden changes in the amplitude of at least one electrical parameter, in particular of the current and/or of the voltage, within an electrical network, according to a method according to one of claims 6 to 15, characterised in that an output of the sensor is applied to an input of a first unit for the formation of a signum function of the electrical parameter, that an output of the first unit is applied to an input of an edge detector, that an output of the edge detector is applied to an input of a second unit for the determination of a duty factor of a rectangular function, and that an output of the second unit is applied to an input of an output unit.
A mobility management method in an M2M network, characterized by comprising: after an M2M terminal/terminal peripheral has registered to an M2M communication network through a mobility management unit, if the M2M terminal/terminal peripheral switches to an M2M stub network, an M2M gateway acquiring information of the M2M terminal/terminal peripheral from the mobility management unit, wherein the step of the M2M gateway acquiring information of the M2M terminal/terminal peripheral from the mobility management unit comprises: the M2M gateway receiving an attachment request sent by the M2M terminal/terminal peripheral, wherein, the attachment request comprises a terminal device identity; requesting the mobility management unit for subscription data of the M2M terminal/terminal peripheral, wherein request information comprises the terminal device identity; and receiving the subscription data of the M2M terminal/terminal peripheral sent by the mobility management unit. after an M2M terminal/terminal peripheral has registered to an M2M communication network through a mobility management unit, if the M2M terminal/terminal peripheral switches to an M2M stub network, an M2M gateway acquiring information of the M2M terminal/terminal peripheral from the mobility management unit, the M2M gateway receiving an attachment request sent by the M2M terminal/terminal peripheral, wherein, the attachment request comprises a terminal device identity; requesting the mobility management unit for subscription data of the M2M terminal/terminal peripheral, wherein request information comprises the terminal device identity; and receiving the subscription data of the M2M terminal/terminal peripheral sent by the mobility management unit.
Headlamp device for a motor vehicle having a matrix headlamp unit which is designed to radiate in each case one light cone into different space segments of a surrounding area of the motor vehicle and depending on a control signal to switch each of the light cones independently of the other light cones between an active state and an inactive state, wherein each light cone has a respective cone dimension (28, 30) along a predetermined direction in a plane perpendicular to the vehicle longitudinal axis, wherein by means of a spatial arrangement of the light cones a lighting intensity of the matrix headlamp unit, measured in the plane and along the direction, has a predetermined undulation, wherein the headlamp device comprises an additional headlamp unit which is designed to radiate three additional light cones having at least one doubled cone dimension, measured in the same direction and the same plane as the cone dimension (28, 30), such that a total undulation of the lighting intensity of the headlamp device is smaller than the undulation which occurs exclusively by means of the matrix headlamp unit, wherein the lighting intensity of the headlamp device by means of the combination of the matrix headlamp unit and the additional headlamp unit lies in each of the space segments below a respectively predetermined first threshold value, wherein the additional headlamp unit is designed, in the case that at least one of the light cones of the matrix headlamp unit is in the inactive state, to switch the additional light cone radiating into the same space segment as the corresponding light cone by means of a control signal of the control unit also into an inactive state, and wherein the additional headlamp unit is designed to radiate one of the three additional light cones at least partially into the space segments which are arranged in a central frontal region comprising the vehicle longitudinal axis, symmetrically to the vehicle longitudinal axis, and wherein the additional headlamp unit is designed to radiate the two remaining of the three additional light cones at least partially onto a respective space segment disposed at the lateral edge of the space segments, wherein a drop in the lighting intensity by means of the combination of the matrix headlamp unit and the additional headlamp unit is less strong than is the case in the exclusive use of the matrix headlamp unit alone, characterised in that the lighting intensity of the headlamp device by means of the combination of the matrix headlamp unit and the additional headlamp unit varies in each of the space segments covered by the additional light cones by less than a predetermined percentage-wise second threshold value.
A shape memory alloy actuation apparatus for moving a movable element relative to a support structure in two orthogonal directions, the shape memory alloy actuation apparatus comprising: a support structure; a movable element supported on the support structure in a manner allowing movement of the movable element relative to the support structure across a range of movement in two orthogonal directions perpendicular to a notional primary axis extending through the movable element; and a total of four shape memory alloy actuator wires connected between the movable element and the support structure in an arrangement wherein none of the shape memory alloy actuator wires are collinear, and wherein the shape memory alloy actuator wires are capable of being selectively driven to move the movable element relative to the support structure to any position in said range of movement without applying any net torque to the movable element in the plane of the two orthogonal directions around the primary axis. a support structure; a movable element supported on the support structure in a manner allowing movement of the movable element relative to the support structure across a range of movement in two orthogonal directions perpendicular to a notional primary axis extending through the movable element; and a total of four shape memory alloy actuator wires connected between the movable element and the support structure in an arrangement wherein none of the shape memory alloy actuator wires are collinear, and wherein the shape memory alloy actuator wires are capable of being selectively driven to move the movable element relative to the support structure to any position in said range of movement without applying any net torque to the movable element in the plane of the two orthogonal directions around the primary axis.
A process for the preparation of compounds of formula 1 wherein X is hydrogen, halogen, thiol, thioether, or amide or halogenide of sulphonic acid, R is hydrogen, alkyl, alkoxyalkyl, haloalkyl, aryl or arylalkyl, comprising the steps of a) reaction of the compound of formula 2 wherein X and R have the above mentioned meanings and Z is an halogen or a sulphonic ester, with an alcohol or a diol to give the ketal of formula 3 wherein X, R and Z have the above mentioned meaning and R 1 is an alkyl, linear or branched, or arylalkyl, and the two groups R 1 can be separated or joined to form a cycle, b) cyclization of the compound of formula 3 to form the compound of formula 4 wherein X, R and R 1 have the above mentioned meaning, c) hydrolysis of the compound of formula 4. wherein X is hydrogen, halogen, thiol, thioether, or amide or halogenide of sulphonic acid, R is hydrogen, alkyl, alkoxyalkyl, haloalkyl, aryl or arylalkyl, a) reaction of the compound of formula 2 wherein X and R have the above mentioned meanings and Z is an halogen or a sulphonic ester, with an alcohol or a diol to give the ketal of formula 3 wherein X, R and Z have the above mentioned meaning and R 1 is an alkyl, linear or branched, or arylalkyl, and the two groups R 1 can be separated or joined to form a cycle, b) cyclization of the compound of formula 3 to form the compound of formula 4 wherein X, R and R 1 have the above mentioned meaning, c) hydrolysis of the compound of formula 4.