A compound(s) or its pharmaceutically-acceptable salt(s) as shown by Formula, R 3 is any selected from 5-membered heterocycles, C 6∼12 aryl groups, C 6∼12 aralkyl groups, C 5∼12 heteroaromatic rings and C 5∼12 heteroaryl groups substituted with R 01; L 2 is independently selected respectively from m 1 and m 2 are independently selected respectively from 1, 2, or 3; X 1 and X 2 are independently selected from -C(R d1)(R d2)-, -C(=O)N(R d3)-, -N(R d4)-, -C(=NR d5)-, -S(=O) 2 N(R d6)-, -S(=O)N(R d7)-, -O-, -S-, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)- or -S(=O) 2 -, R 4 is selected from 5∼14-membered cyclic hydrocarbyl or heterocycloalkyl groups, R d1 and R d2 are independently selected respectively from H, F, Cl, Br, I, CN, OH, SH, NH 2, CHO, COOH or any selected from C 1-10 alkyl or heteroalkyl groups and C 3-10 cyclic hydrocarbyl or heterocycloalkyl groups substituted with R 01, C 1-10 alkyl or heteroalkyl groups substituted with C 3-10 hydrocarbyl or heterocycloalkyl groups; R 01 is selected from F, Cl, Br, I, CN, OH, SH, NH2, CHO, COOH, R 02; R 02 is selected from C 1-10 alkaly groups, C 1-10 alkylamino groups, N,N-(C 1-10 alkayl) amino groups, C 1-10 alkoxy groups, C 1-10 alkanoyl groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylsulfonyl groups, C 1-10 alkylsulfinyl groups, C3-10 cycloalkyl groups, C 3-10 cycloalkylamino groups, C 3-10 heterocyclic alkyl amino groups, C 3-10 cycloalkoxy groups, C 3-10 cycloalkyl acyl groups, C 3-10 cycloalkoxy-carbonyl groups, C 3-10 cycloalkylsulfonyl groups and C 3-10 cycloalkylsulfinyl groups; the "hetero" represents a hetero atom or hetero atom radical selected from -C(=O)N(R d3)-, -N(R d4)-, -C(=NR d5)-, -S(=O) 2 N(R d6)-, -S(=O)N(R d7)-, -O-, -S-, =O, =S, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)- and/or -S(=O) 2; R d3-d7 is independently selected from H, R 03; R 03 is selected from C 1-10 alkyl groups, C 1-10 alkanoyl groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylsulfonyl groups, C 1-10 alkylsulfinyl groups, C 3-10 cycloalkyl groups, C 3-10 ycloalkyl acyl groups, C 3-10 cycloalkoxy-carbonyl groups, C 3-10 cycloalkylsulfonyl groups and C 3-10 cycloalkylsulfinyl groups; R 02 and R 03 are any substituted necessarily by R 001; R 001 is selected from F, Cl, Br, I, CN, OH, N(CH 3) 2, NH(CH 3), NH 2, CHO, COOH, trifluoromethyl group, aminomethyl group, hydroxymethyl group, methyl group, methoxy group, formyl group, methoxycarbonyl group, methylsulfonyl group and methylsulfinyl group; the number of R 01, R 001 and hetero atom or hetero atom radical is independently selected respectively from 0, 1, 2 or 3; optionally, R d1 and R d2 interconnect together to form a 3 or 4-membered carbocyclic or heterocyclic ring. R 3 is any selected from 5-membered heterocycles, C 6∼12 aryl groups, C 6∼12 aralkyl groups, C 5∼12 heteroaromatic rings and C 5∼12 heteroaryl groups substituted with R 01; L 2 is independently selected respectively from m 1 and m 2 are independently selected respectively from 1, 2, or 3; X 1 and X 2 are independently selected from -C(R d1)(R d2)-, -C(=O)N(R d3)-, -N(R d4)-, -C(=NR d5)-, -S(=O) 2 N(R d6)-, -S(=O)N(R d7)-, -O-, -S-, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)- or -S(=O) 2 -, R 4 is selected from 5∼14-membered cyclic hydrocarbyl or heterocycloalkyl groups, R d1 and R d2 are independently selected respectively from H, F, Cl, Br, I, CN, OH, SH, NH 2, CHO, COOH or any selected from C 1-10 alkyl or heteroalkyl groups and C 3-10 cyclic hydrocarbyl or heterocycloalkyl groups substituted with R 01, C 1-10 alkyl or heteroalkyl groups substituted with C 3-10 hydrocarbyl or heterocycloalkyl groups; R 01 is selected from F, Cl, Br, I, CN, OH, SH, NH2, CHO, COOH, R 02; R 02 is selected from C 1-10 alkaly groups, C 1-10 alkylamino groups, N,N-(C 1-10 alkayl) amino groups, C 1-10 alkoxy groups, C 1-10 alkanoyl groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylsulfonyl groups, C 1-10 alkylsulfinyl groups, C3-10 cycloalkyl groups, C 3-10 cycloalkylamino groups, C 3-10 heterocyclic alkyl amino groups, C 3-10 cycloalkoxy groups, C 3-10 cycloalkyl acyl groups, C 3-10 cycloalkoxy-carbonyl groups, C 3-10 cycloalkylsulfonyl groups and C 3-10 cycloalkylsulfinyl groups; the "hetero" represents a hetero atom or hetero atom radical selected from -C(=O)N(R d3)-, -N(R d4)-, -C(=NR d5)-, -S(=O) 2 N(R d6)-, -S(=O)N(R d7)-, -O-, -S-, =O, =S, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)- and/or -S(=O) 2; R d3-d7 is independently selected from H, R 03; R 03 is selected from C 1-10 alkyl groups, C 1-10 alkanoyl groups, C 1-10 alkoxycarbonyl groups, C 1-10 alkylsulfonyl groups, C 1-10 alkylsulfinyl groups, C 3-10 cycloalkyl groups, C 3-10 ycloalkyl acyl groups, C 3-10 cycloalkoxy-carbonyl groups, C 3-10 cycloalkylsulfonyl groups and C 3-10 cycloalkylsulfinyl groups; R 02 and R 03 are any substituted necessarily by R 001; R 001 is selected from F, Cl, Br, I, CN, OH, N(CH 3) 2, NH(CH 3), NH 2, CHO, COOH, trifluoromethyl group, aminomethyl group, hydroxymethyl group, methyl group, methoxy group, formyl group, methoxycarbonyl group, methylsulfonyl group and methylsulfinyl group; the number of R 01, R 001 and hetero atom or hetero atom radical is independently selected respectively from 0, 1, 2 or 3; optionally, R d1 and R d2 interconnect together to form a 3 or 4-membered carbocyclic or heterocyclic ring.