A power and cooling system (100; 400) comprising a drive system (106; 406; 500) having a drive shaft with a turbine (114; 412; 504), a first compressor (116; 506), and a second compressor (118; 508) each operably coupled to the drive shaft; a power generation unit (102; 402; 514) defining a power generation flow path (122; 410; 512) of a primary working fluid that is expanded within the turbine (114; 412; 504) of the drive system (106; 406; 500) and compressed within the first compressor (116; 506) and the second compressor (118; 508) in a closed-loop cycle, the power generation unit (102; 402; 514) comprising: a generator (132; 414) configured to generate electrical power, the generator (132; 414) driven by the drive shaft of the drive system (106; 406; 500); and a heat source configured to heat the primary working fluid prior to injection into the turbine (114; 412; 504); and a cooled fluid generation unit (104; 404; 518) defining a cooled fluid flow path of a portion of the primary working fluid that is extracted from the second compressor (118; 508) and compressed within the first compressor (116; 506), the cooled fluid generation unit (104; 404; 518) comprising: an ejector (140; 420) downstream of the second compressor (118; 508) along the cooled fluid flow path; and a separator arranged downstream of the ejector (140; 420) and configured to separate liquid and gaseous portions of the primary working fluid, wherein the gaseous portion is directed to the first compressor (116; 506) and the liquid portion is directed to an evaporator heat exchanger (144; 428) to generate a cooled fluid, wherein the primary working fluid is directed to the ejector (140; 420) after passing through the evaporator heat exchanger (144; 428). a drive system (106; 406; 500) having a drive shaft with a turbine (114; 412; 504), a first compressor (116; 506), and a second compressor (118; 508) each operably coupled to the drive shaft; a power generation unit (102; 402; 514) defining a power generation flow path (122; 410; 512) of a primary working fluid that is expanded within the turbine (114; 412; 504) of the drive system (106; 406; 500) and compressed within the first compressor (116; 506) and the second compressor (118; 508) in a closed-loop cycle, the power generation unit (102; 402; 514) comprising: a generator (132; 414) configured to generate electrical power, the generator (132; 414) driven by the drive shaft of the drive system (106; 406; 500); and a heat source configured to heat the primary working fluid prior to injection into the turbine (114; 412; 504); and a cooled fluid generation unit (104; 404; 518) defining a cooled fluid flow path of a portion of the primary working fluid that is extracted from the second compressor (118; 508) and compressed within the first compressor (116; 506), the cooled fluid generation unit (104; 404; 518) comprising: an ejector (140; 420) downstream of the second compressor (118; 508) along the cooled fluid flow path; and a separator arranged downstream of the ejector (140; 420) and configured to separate liquid and gaseous portions of the primary working fluid, wherein the gaseous portion is directed to the first compressor (116; 506) and the liquid portion is directed to an evaporator heat exchanger (144; 428) to generate a cooled fluid, wherein the primary working fluid is directed to the ejector (140; 420) after passing through the evaporator heat exchanger (144; 428). a generator (132; 414) configured to generate electrical power, the generator (132; 414) driven by the drive shaft of the drive system (106; 406; 500); and a heat source configured to heat the primary working fluid prior to injection into the turbine (114; 412; 504); and a cooled fluid generation unit (104; 404; 518) defining a cooled fluid flow path of a portion of the primary working fluid that is extracted from the second compressor (118; 508) and compressed within the first compressor (116; 506), the cooled fluid generation unit (104; 404; 518) comprising: an ejector (140; 420) downstream of the second compressor (118; 508) along the cooled fluid flow path; and a separator arranged downstream of the ejector (140; 420) and configured to separate liquid and gaseous portions of the primary working fluid, wherein the gaseous portion is directed to the first compressor (116; 506) and the liquid portion is directed to an evaporator heat exchanger (144; 428) to generate a cooled fluid, wherein the primary working fluid is directed to the ejector (140; 420) after passing through the evaporator heat exchanger (144; 428). an ejector (140; 420) downstream of the second compressor (118; 508) along the cooled fluid flow path; and a separator arranged downstream of the ejector (140; 420) and configured to separate liquid and gaseous portions of the primary working fluid, wherein the gaseous portion is directed to the first compressor (116; 506) and the liquid portion is directed to an evaporator heat exchanger (144; 428) to generate a cooled fluid, wherein the primary working fluid is directed to the ejector (140; 420) after passing through the evaporator heat exchanger (144; 428).