A resealable bag (100, 200, 400, 600, 700) comprising: a first sidewall (111, 211, 411, 611); a second sidewall (112, 212, 412, 612) connected to the first sidewall (111, 211, 411, 611) to form a closed bottom (160, 260, 660), the sidewalls coupled together along their side edges (141, 143, 241, 243, 441, 443, 741, 743) and extending upwardly from the closed bottom (160, 260, 660) to form an upper end (125, 225, 425) of the bag (100, 200, 400, 600, 700); a tamper-evident seal (120, 220, 420, 620) disposed along the upper end (125, 225, 425) of the bag (100, 200, 400, 600, 700) coupled to the first sidewall (111, 211, 411, 611) and the second sidewall (112, 212, 412, 612) by a structurally weakened region (130, 230, 430, 630); a resealable closure (150, 250, 450, 650, 750) disposed along interior surfaces (207, 607) of the first and second sidewalls (111, 112, 211, 212, 411, 412, 611, 612) between 2,54-5,08cm (1 inch to 2 inches) below a lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), the resealable closure (150, 250, 450, 650, 750) comprising a female component (497, 654) coupled to the first sidewall (111, 211, 411, 611) and a male component (498, 652) coupled to the second sidewall (112, 212, 412, 612), characterized in that a first flange (281, 481) is coupled to the first sidewall (111, 211, 411, 611), the first flange (281, 481) comprising an upper edge (283, 483) and a bottom edge (286, 486) the upper edge (283, 483) of the first flange (281, 481) being disposed at least 1,27cm (0.5 inches) from the lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), and the first flange (281, 481) being continuously sealed to the first sidewall (111, 211, 411, 611) between the upper edge (283, 483) and the bottom edge (286, 486) of the first flange (281, 481); a second flange (282, 482) is coupled to the second sidewall (112, 212, 412, 612), the second flange (282, 482) comprising an upper edge (284, 484) and a bottom edge (287, 487), the upper edge (284, 484) of the second flange (282, 482) being disposed at least 1,27cm (0.5 inches) from the lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), and the second flange (282, 482) being continuously sealed to the second sidewall (112, 212, 412, 612) between the upper edge (284, 484) and the bottom edge (287, 487) of the second flange (282, 482), wherein the female component (497, 654) is disposed on the first flange (281, 481) and the male component (498, 652) is disposed on the second flange (282, 482); wherein a vertical distance between the structurally weakened region (130, 230, 430, 630) and the resealable closure (150, 250, 450, 650, 750) is greater than a second vertical distance from an upper edge of the first flange to a lower edge of the first flange. a first sidewall (111, 211, 411, 611); a second sidewall (112, 212, 412, 612) connected to the first sidewall (111, 211, 411, 611) to form a closed bottom (160, 260, 660), the sidewalls coupled together along their side edges (141, 143, 241, 243, 441, 443, 741, 743) and extending upwardly from the closed bottom (160, 260, 660) to form an upper end (125, 225, 425) of the bag (100, 200, 400, 600, 700); a tamper-evident seal (120, 220, 420, 620) disposed along the upper end (125, 225, 425) of the bag (100, 200, 400, 600, 700) coupled to the first sidewall (111, 211, 411, 611) and the second sidewall (112, 212, 412, 612) by a structurally weakened region (130, 230, 430, 630); a resealable closure (150, 250, 450, 650, 750) disposed along interior surfaces (207, 607) of the first and second sidewalls (111, 112, 211, 212, 411, 412, 611, 612) between 2,54-5,08cm (1 inch to 2 inches) below a lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), the resealable closure (150, 250, 450, 650, 750) comprising a female component (497, 654) coupled to the first sidewall (111, 211, 411, 611) and a male component (498, 652) coupled to the second sidewall (112, 212, 412, 612), characterized in that a first flange (281, 481) is coupled to the first sidewall (111, 211, 411, 611), the first flange (281, 481) comprising an upper edge (283, 483) and a bottom edge (286, 486) the upper edge (283, 483) of the first flange (281, 481) being disposed at least 1,27cm (0.5 inches) from the lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), and the first flange (281, 481) being continuously sealed to the first sidewall (111, 211, 411, 611) between the upper edge (283, 483) and the bottom edge (286, 486) of the first flange (281, 481); a second flange (282, 482) is coupled to the second sidewall (112, 212, 412, 612), the second flange (282, 482) comprising an upper edge (284, 484) and a bottom edge (287, 487), the upper edge (284, 484) of the second flange (282, 482) being disposed at least 1,27cm (0.5 inches) from the lowermost edge (121, 221, 421) of the tamper-evident seal (120, 220, 420, 620), and the second flange (282, 482) being continuously sealed to the second sidewall (112, 212, 412, 612) between the upper edge (284, 484) and the bottom edge (287, 487) of the second flange (282, 482), wherein the female component (497, 654) is disposed on the first flange (281, 481) and the male component (498, 652) is disposed on the second flange (282, 482);