mhurhangee/ep-ind-claims huggingface dataset:
A system for dispensing insulin to a body of a user, the system comprising: a delivery apparatus for delivering an insulin bolus to a user; and a device comprising a tangible machine-readable storage medium embodying instructions that when performed by one or more machines are configured to: select a first value (T DIA) corresponding to a duration of insulin action; select a second value (T LOT) corresponding to a lock out time duration indicative of a period of time directly prior to delivery of the insulin bolus and food intake and during which delivered insulin does not affect consumed carbohydrates; select a first time period beginning at a time point T 0 minus the first value (T DIA) and ending at the time point T 0 minus the second value (T LOT); select one or more boluses delivered during the first time period; select a corresponding residual insulin value estimated at the time point T 0 for each of the one or more boluses; compute a cumulative residual insulin value by summation of the corresponding residual insulin values; and determine the insulin bolus based on the cumulative residual insulin value. a delivery apparatus for delivering an insulin bolus to a user; and a device comprising a tangible machine-readable storage medium embodying instructions that when performed by one or more machines are configured to: select a first value (T DIA) corresponding to a duration of insulin action; select a second value (T LOT) corresponding to a lock out time duration indicative of a period of time directly prior to delivery of the insulin bolus and food intake and during which delivered insulin does not affect consumed carbohydrates; select a first time period beginning at a time point T 0 minus the first value (T DIA) and ending at the time point T 0 minus the second value (T LOT); select one or more boluses delivered during the first time period; select a corresponding residual insulin value estimated at the time point T 0 for each of the one or more boluses; compute a cumulative residual insulin value by summation of the corresponding residual insulin values; and determine the insulin bolus based on the cumulative residual insulin value. select a first value (T DIA) corresponding to a duration of insulin action; select a second value (T LOT) corresponding to a lock out time duration indicative of a period of time directly prior to delivery of the insulin bolus and food intake and during which delivered insulin does not affect consumed carbohydrates; select a first time period beginning at a time point T 0 minus the first value (T DIA) and ending at the time point T 0 minus the second value (T LOT); select one or more boluses delivered during the first time period; select a corresponding residual insulin value estimated at the time point T 0 for each of the one or more boluses; compute a cumulative residual insulin value by summation of the corresponding residual insulin values; and determine the insulin bolus based on the cumulative residual insulin value.
A multi-section forming element for creating a construction joint, comprising - a lower part, - an upper part and - a water bar, - wherein the lower part comprises lower brackets transversely extending to both sides of the construction joint, - wherein the lower brackets each comprise a vertical leg that is fixed on a lower formwork component and a lateral leg, - wherein the upper part comprises upper brackets transversely extending to both sides of the construction joint, - wherein the upper brackets each comprise a vertical leg that is fixed on an upper formwork component and a lateral leg, characterized in that - the upper part and the lower part are detachably connected to one another in such a way that a region for accommodating the water bar is arranged between the upper part and the lower part, - a connecting element extending over the length of the construction joint is fixed on the lateral legs of the lower brackets, - the upper part and the lower part are detachably connected to one another in such a way that the lower formwork component and the upper formwork component are aligned one upon another, - the water bar is fixed on the lower and/or the upper brackets under tension by aid of fastening means, and - the lower formwork component and the upper formwork component are in contact with the water bar. - a lower part, - an upper part and - a water bar, - wherein the lower part comprises lower brackets transversely extending to both sides of the construction joint, - wherein the lower brackets each comprise a vertical leg that is fixed on a lower formwork component and a lateral leg, - wherein the upper part comprises upper brackets transversely extending to both sides of the construction joint, - wherein the upper brackets each comprise a vertical leg that is fixed on an upper formwork component and a lateral leg, - the upper part and the lower part are detachably connected to one another in such a way that a region for accommodating the water bar is arranged between the upper part and the lower part, - a connecting element extending over the length of the construction joint is fixed on the lateral legs of the lower brackets, - the upper part and the lower part are detachably connected to one another in such a way that the lower formwork component and the upper formwork component are aligned one upon another, - the water bar is fixed on the lower and/or the upper brackets under tension by aid of fastening means, and - the lower formwork component and the upper formwork component are in contact with the water bar.
A control device for an internal combustion engine that includes a reducing agent addition system that supplies an ammonia-based reducing agent to a nitrogen oxide purification catalyst arranged in downstream of an exhaust passage by adding the ammonia-based reducing agent into the exhaust passage of the internal combustion engine through an addition valve, the control device further comprising: an exhaust gas temperature suppressor that, when it is not possible to add the ammonia-based reducing agent into the exhaust passage, suppresses an exhaust gas temperature in the exhaust passage to a lower temperature than the exhaust gas temperature when it is possible to add the ammonia-based reducing agent into the exhaust passage, and a particulate matter removal filter that traps particulate matter and of which a filter function is regenerable by burning the deposited particulate matter is provided in the exhaust passage at a location upstream of the addition valve, characterized in that, when it is not possible to add the ammonia-based reducing agent into the exhaust passage, the exhaust gas temperature suppressor executes a temperature decreasing process of decreasing the exhaust gas temperature in the exhaust passage as compared to the exhaust gas temperature when it is possible to add the ammonia-based reducing agent into the exhaust passage, wherein, when it is not possible to add the ammonia-based reducing agent into the exhaust passage, the exhaust gas temperature suppressor executes, as the temperature decreasing process, a temperature decreasing process of decreasing a regeneration temperature of the particulate matter removal filter as compared to the regeneration temperature when it is possible to add the ammonia-based reducing agent into the exhaust passage. an exhaust gas temperature suppressor that, when it is not possible to add the ammonia-based reducing agent into the exhaust passage, suppresses an exhaust gas temperature in the exhaust passage to a lower temperature than the exhaust gas temperature when it is possible to add the ammonia-based reducing agent into the exhaust passage, and a particulate matter removal filter that traps particulate matter and of which a filter function is regenerable by burning the deposited particulate matter is provided in the exhaust passage at a location upstream of the addition valve,
An apparatus, comprising: a voltage pulse generator configured to produce a pulsed voltage waveform, the pulsed voltage waveform being a biphasic waveform including a pre-polarizing pulse followed by a polarizing pulse, the pre-polarizing pulse being generated by utilizing voltage spikes generated from switching on a discharge of a capacitor bank; and an electrode controller configured to be operably coupled to the voltage pulse generator and a medical device including a plurality of electrodes, the electrode controller implemented in at least one of a memory or a processor, the electrode controller including a selection module and a pulse delivery module, the selection module configured to select a subset of electrodes from the plurality of electrodes, the selection module configured to identify at least a first electrode from the subset of electrodes as an anode and at least a second electrode from the subset of electrodes as a cathode, the pulse delivery module configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes. a voltage pulse generator configured to produce a pulsed voltage waveform, the pulsed voltage waveform being a biphasic waveform including a pre-polarizing pulse followed by a polarizing pulse, the pre-polarizing pulse being generated by utilizing voltage spikes generated from switching on a discharge of a capacitor bank; and an electrode controller configured to be operably coupled to the voltage pulse generator and a medical device including a plurality of electrodes, the electrode controller implemented in at least one of a memory or a processor, the electrode controller including a selection module and a pulse delivery module, the selection module configured to select a subset of electrodes from the plurality of electrodes, the selection module configured to identify at least a first electrode from the subset of electrodes as an anode and at least a second electrode from the subset of electrodes as a cathode, the pulse delivery module configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.
A composition for use in the treatment of a cancer that contains cancer stem cells, or for preventing metastasis or recurrence of such a cancer, in a mammal affected by such a cancer or with a history of having such a cancer, wherein said composition is for administration in combination with a chemotherapeutic agent, for enhancing sensitivity of said cancer to the chemotherapeutic agent, the composition comprising: isoleucine or a salt thereof, leucine or a salt thereof, and valine or a salt thereof.
An antibody or antibody fragment capable of activating CD4+CD25+ regulatory T cells, wherein the antibody or antibody fragment comprises: (i) a light chain CDR1 comprising: Arg, Lys, Gln or Asn 24; Ala or Gly 25; Ser or Thr 26; Lys, Arg or Glu 27; Ser, Gly or Pro 28; Val, Ala or Ile 29; Ser 30; Thr, Ser, Asn, Gln or Asp 31; Ser 32; Gly 33; Tyr 34; Ser 35; Tyr 36; Ile, Val or Leu 37; and Tyr 38; (ii) a light chain CDR2 comprising: Leu 54; Ala 55; Ser 56; Ile 57; Leu 58; Glu 59; and Ser, Asn, Gln, Thr, Glu or Asp 60; (iii) a light chain CDR3 comprising: Gln 93; His 94; Ser 95; Arg or Lys 96; Glu, Asp or Arg 97; Leu, Gly or Ile 98; Pro 99; Trp 100; and Thr or Ser 101; (iv) a heavy chain CDR1 comprising: Asp, Glu, Thr, Cys, Pro, Met or Tyr 31; Cys, Ser, Ala, Gly or Val 32; Arg, Lys, Ser, Thr or Glu 33; Met, Ile, Leu, Ala or Val 34; and Tyr 35; (v) a heavy chain CDR2 comprising: Ile, Ala, Val or Gly 51; Ser, Asp, Gly, Ala, or Thr 52; Val, Ser, Gly, Thr or Ile 53; Lys, Arg, or Tyr 54; Ser, Asn, Gln, Thr or Glu 55; Glu, Asp or Arg 56; Asn, Asp, Tyr, Gln or Glu 57; Tyr, His or Lys 58; Gly or Ser 59; Ala, Ser or Thr 60; Asn, Gln or Asp 61; Tyr, Phe or His 62; Ala, Gly or Ser 63; Glu, Asp, Gln, Asn or Arg 64; Ser, Gly, Ala or Asn 65; Val, Ile, Ala, Ser or Gly 66; Arg, Lys, Gln, Tyr, His or Glu 67; and Gly 68; and (vi) a heavy chain CDR3 comprising: Ser 101; Tyr 102; Tyr, Phe or His 103; Arg 104; Tyr 105; Asp 106; Val, Ile, Pro, Asp, Thr or Glu 107; Gly or Ala 108; Ala or Ser 109; Trp, Phe, His or Tyr 110; Phe 111, Ala or Ser 112; and Tyr, Phe, His or Asn 113, and wherein the antibody or antibody fragment does not comprise CDR1, CDR2 and CDR3 of BT061 heavy chain and CDR1, CDR2 and CDR3 of BT061 light chain. (i) a light chain CDR1 comprising: Arg, Lys, Gln or Asn 24; Ala or Gly 25; Ser or Thr 26; Lys, Arg or Glu 27; Ser, Gly or Pro 28; Val, Ala or Ile 29; Ser 30; Thr, Ser, Asn, Gln or Asp 31; Ser 32; Gly 33; Tyr 34; Ser 35; Tyr 36; Ile, Val or Leu 37; and Tyr 38; (ii) a light chain CDR2 comprising: Leu 54; Ala 55; Ser 56; Ile 57; Leu 58; Glu 59; and Ser, Asn, Gln, Thr, Glu or Asp 60; (iii) a light chain CDR3 comprising: Gln 93; His 94; Ser 95; Arg or Lys 96; Glu, Asp or Arg 97; Leu, Gly or Ile 98; Pro 99; Trp 100; and Thr or Ser 101; (iv) a heavy chain CDR1 comprising: Asp, Glu, Thr, Cys, Pro, Met or Tyr 31; Cys, Ser, Ala, Gly or Val 32; Arg, Lys, Ser, Thr or Glu 33; Met, Ile, Leu, Ala or Val 34; and Tyr 35; (v) a heavy chain CDR2 comprising: Ile, Ala, Val or Gly 51; Ser, Asp, Gly, Ala, or Thr 52; Val, Ser, Gly, Thr or Ile 53; Lys, Arg, or Tyr 54; Ser, Asn, Gln, Thr or Glu 55; Glu, Asp or Arg 56; Asn, Asp, Tyr, Gln or Glu 57; Tyr, His or Lys 58; Gly or Ser 59; Ala, Ser or Thr 60; Asn, Gln or Asp 61; Tyr, Phe or His 62; Ala, Gly or Ser 63; Glu, Asp, Gln, Asn or Arg 64; Ser, Gly, Ala or Asn 65; Val, Ile, Ala, Ser or Gly 66; Arg, Lys, Gln, Tyr, His or Glu 67; and Gly 68; and (vi) a heavy chain CDR3 comprising: Ser 101; Tyr 102; Tyr, Phe or His 103; Arg 104; Tyr 105; Asp 106; Val, Ile, Pro, Asp, Thr or Glu 107; Gly or Ala 108; Ala or Ser 109; Trp, Phe, His or Tyr 110; Phe 111, Ala or Ser 112; and Tyr, Phe, His or Asn 113,
A method for manufacturing a molding tool intended for molding a part made of composite material, characterized in that it comprises the following steps: a) A support is provided. b) On the support is disposed a first stacking of reinforcing fibers which are possibly impregnated with a thermosetting or a thermoplastic resin. c) On the first stacking of reinforcing fibers is disposed a circuit comprising at least one tube made of a material of low thermal expansion coefficient, said circuit having the shape of a heat carrying fluid circuit adapted to the molding tool. d) On the circuit is disposed a second stacking of reinforcing fibers which are possibly impregnated with a thermosetting or a thermoplastic resin. e) The set constituted by the first stacking of reinforcing fibers, the circuit, the second stacking of reinforcing fibers, is compressed, and where appropriate when the reinforcing fibers are not impregnated with a thermoplastic or a thermosetting resin, a thermoplastic or a thermosetting resin is infused. f) A thermal cycle is carried out, said thermal cycle being designed in such a manner as to harden the thermosetting or the thermoplastic resin in order to obtain a molded shape. g) The molded shape obtained from step f) is stripped. a) A support is provided. b) On the support is disposed a first stacking of reinforcing fibers which are possibly impregnated with a thermosetting or a thermoplastic resin. c) On the first stacking of reinforcing fibers is disposed a circuit comprising at least one tube made of a material of low thermal expansion coefficient, said circuit having the shape of a heat carrying fluid circuit adapted to the molding tool. d) On the circuit is disposed a second stacking of reinforcing fibers which are possibly impregnated with a thermosetting or a thermoplastic resin. e) The set constituted by the first stacking of reinforcing fibers, the circuit, the second stacking of reinforcing fibers, is compressed, and where appropriate when the reinforcing fibers are not impregnated with a thermoplastic or a thermosetting resin, a thermoplastic or a thermosetting resin is infused. f) A thermal cycle is carried out, said thermal cycle being designed in such a manner as to harden the thermosetting or the thermoplastic resin in order to obtain a molded shape. g) The molded shape obtained from step f) is stripped.
A human monoclonal antibody or an antigen-binding portion thereof that specifically binds to M-CSF, wherein the antibody comprises: (a) a heavy chain amino acid sequence that is at least 90% identical to the heavy chain amino acid sequence of SEQ ID NO: 26 without the nineteen amino acid residues of the signal sequence (residues 1-19 of SEQ ID NO: 26), and (b) a light chain amino acid sequence that is at least 90% identical to the light chain amino acid sequence of SEQ ID NO: 28 without the twenty-two amino acid residues of the signal sequence (residues 1-22 of SEQ ID NO: 28); and wherein the antibody has at least one of the properties selected from the group consisting of: (i) inhibits M-CSF-dependent cell proliferation with an IC 50 of 8 x 10 -8 M or less; (ii) inhibits M-CSF-dependent human monocyte shape change with an IC 50 of 9 x 10 -8 M or less; and (iii) inhibits M-CSF receptor binding with an IC 50 of 7 x 10 -8 M or less. (a) a heavy chain amino acid sequence that is at least 90% identical to the heavy chain amino acid sequence of SEQ ID NO: 26 without the nineteen amino acid residues of the signal sequence (residues 1-19 of SEQ ID NO: 26), and (b) a light chain amino acid sequence that is at least 90% identical to the light chain amino acid sequence of SEQ ID NO: 28 without the twenty-two amino acid residues of the signal sequence (residues 1-22 of SEQ ID NO: 28); and wherein the antibody has at least one of the properties selected from the group consisting of: (i) inhibits M-CSF-dependent cell proliferation with an IC 50 of 8 x 10 -8 M or less; (ii) inhibits M-CSF-dependent human monocyte shape change with an IC 50 of 9 x 10 -8 M or less; and (iii) inhibits M-CSF receptor binding with an IC 50 of 7 x 10 -8 M or less. (i) inhibits M-CSF-dependent cell proliferation with an IC 50 of 8 x 10 -8 M or less; (ii) inhibits M-CSF-dependent human monocyte shape change with an IC 50 of 9 x 10 -8 M or less; and (iii) inhibits M-CSF receptor binding with an IC 50 of 7 x 10 -8 M or less.
A method for the automatically activatable secure connection of a climbing bracket to a hook on an anchoring device embedded in a substructure, having the following steps: a. bringing the climbing bracket up to the substructure, b. inserting the hook into the anchoring device, c. fitting the hook and lowering the climbing bracket in the anchoring device, d. activating a securing element by lowering the hook in the climbing bracket and e. locking the hook and the securing element in the anchoring device and adjusting the secure connection with the anchoring device, characterized in that the securing element is substantially formed to have two arms and is pivoted upwards about an axis on the hook when the securing element is activated by lowering the hook such that a first arm of the securing element enters a cross-sectional widening of the anchoring device located above an insertion opening of the anchoring device for the hook, and at the same time a second arm (19") of the securing element is locked onto a latching and release device on the climbing bracket such that the hook together with the climbing bracket can no longer be released from the anchoring device and the climbing bracket is prevented from being pulled out of the anchoring device, because the vertical extension of the hook and the securing element is greater than the height of the insertion opening in the anchoring device. a. bringing the climbing bracket up to the substructure, b. inserting the hook into the anchoring device, c. fitting the hook and lowering the climbing bracket in the anchoring device, d. activating a securing element by lowering the hook in the climbing bracket and e. locking the hook and the securing element in the anchoring device and adjusting the secure connection with the anchoring device,
A composition comprising an actinically-crosslinkable polysiloxane-polyglycerol block copolymer derived from: a polysiloxane prepolymer comprising a polyglycerol side chain, the polyglycerol side chain comprising an ethylenically unsaturated group covalently linked thereto, wherein the ethylenically unsaturated group is actinically curable.
A processor comprising: means for: processing pre-computed ready state information for at least one of a group of instructions, wherein the group of instructions is configured to execute atomically by the processor, characterized by scheduling the at least one of the group of instructions for execution by the processor, before at least one of fetching or decoding the at least one of the group of instructions, based at least on the pre-computed ready state information for the at least one of the group of instructions. processing pre-computed ready state information for at least one of a group of instructions, wherein the group of instructions is configured to execute atomically by the processor, characterized by scheduling the at least one of the group of instructions for execution by the processor, before at least one of fetching or decoding the at least one of the group of instructions, based at least on the pre-computed ready state information for the at least one of the group of instructions.
A method of attaching a load sensor (5, 5a, 5b, 5c, 5d, 5e) to a surface of a rotor blade, the load sensor (5, 5a, 5b, 5c, 5d, 5e) comprising a support with a number of strain gauges and a set of fixing holes with predefined distances (d 1), the method comprising the steps of a) producing a set of holes in the surface of the rotor blade with predefined distances (d 2) between the holes essentially equal to the predefined distances (d 1) of the fixing holes, b) providing threaded inserts in the holes, c) inserting bolts through the load sensor (5, 5a, 5b, 5c, 5d, 5e) into the threaded inserts. a) producing a set of holes in the surface of the rotor blade with predefined distances (d 2) between the holes essentially equal to the predefined distances (d 1) of the fixing holes, b) providing threaded inserts in the holes, c) inserting bolts through the load sensor (5, 5a, 5b, 5c, 5d, 5e) into the threaded inserts.