mhurhangee/ep-ind-claims huggingface dataset:
A medical device comprising: a graphene varactor comprising: a graphene layer; a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions; characterised in that the self-assembled monolayer provides a Langmuir theta value of at least 0.9, and the self-assembled monolayer comprises at least one metallotetraphenylporphyrin compound having the formula: wherein M is any metal atom comprising aluminum, calcium, magnesium, manganese, iron, cobalt, nickel, zinc, ruthenium, palladium, or derivatives thereof; where n can be any integer from 1 to 5; m can be 1 or 2; R 1 through R 8 comprise - H; -X, where X is any halogen atom; -R 9; -R 10 OH; -R 11 COOH; -R 12 COOR 13; - R 14 OR 15; -R 16 COH; -R 17 COR 18; -R 19 NH 3 +; -R 20 NH 2; -R 21 NR 22; -R 23 NR 24 R 25+; -R 26 X or -R 27 COX, where X is any halogen atom; -R 28 SH or any combination thereof; and R 9, through R 28 comprise any linear or branched C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, or any combination thereof, or can be absent such that the remaining portion of the functional group is covalently bound directly to one or more carbon atoms of the base aromatic ring structure. a graphene varactor comprising: a graphene layer; a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions; characterised in that a graphene layer; a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions; characterised in that the self-assembled monolayer provides a Langmuir theta value of at least 0.9, and the self-assembled monolayer comprises at least one metallotetraphenylporphyrin compound having the formula: wherein M is any metal atom comprising aluminum, calcium, magnesium, manganese, iron, cobalt, nickel, zinc, ruthenium, palladium, or derivatives thereof; where n can be any integer from 1 to 5; m can be 1 or 2; R 1 through R 8 comprise - H; -X, where X is any halogen atom; -R 9; -R 10 OH; -R 11 COOH; -R 12 COOR 13; - R 14 OR 15; -R 16 COH; -R 17 COR 18; -R 19 NH 3 +; -R 20 NH 2; -R 21 NR 22; -R 23 NR 24 R 25+; -R 26 X or -R 27 COX, where X is any halogen atom; -R 28 SH or any combination thereof; and R 9, through R 28 comprise any linear or branched C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, or any combination thereof, or can be absent such that the remaining portion of the functional group is covalently bound directly to one or more carbon atoms of the base aromatic ring structure.
A cutter head for a gear cutting tool, said cutter head comprising: an axis of rotation, a first side and a second side spaced axially from one another, at least one rectangular cutting blade mounting and positioning slot arranged in said cutter head and having a length extending from said first side to said second side, said at least one slot comprising a radial seating surface for providing precise and stiff radial positioning of the blade and a tangential seating surface for backing the blade up against the main cutting force, said seating surfaces being arranged perpendicular to one another, a clamping mechanism located in said at least one slot, said clamping mechanism being capable of delivering a clamping force to a corner region of a cutting blade, the cutting blade having a square or rectangular cross-section, mounted in said at least one slot, said corner region being remote from said radial seating surface and said tangential seating surface of said at least one slot, said clamping mechanism further comprising an angular clamping block having a shape complementary to said corner region of the cutting blade, whereby a first portion (F 1a) of the clamping force is directed to and effects a clamping of the cutting blade against said radial seating surface and a second portion (F 1b) of the clamping force is directed to and effects a clamping of the cutting blade against said tangential seating surface, characterised in that a spacing is provided between the angular clamping block and both the surfaces of the slot other than the radial and tangential seating surfaces (14, 18). an axis of rotation, a first side and a second side spaced axially from one another, at least one rectangular cutting blade mounting and positioning slot arranged in said cutter head and having a length extending from said first side to said second side, said at least one slot comprising a radial seating surface for providing precise and stiff radial positioning of the blade and a tangential seating surface for backing the blade up against the main cutting force, said seating surfaces being arranged perpendicular to one another, a clamping mechanism located in said at least one slot, said clamping mechanism being capable of delivering a clamping force to a corner region of a cutting blade, the cutting blade having a square or rectangular cross-section, mounted in said at least one slot, said corner region being remote from said radial seating surface and said tangential seating surface of said at least one slot, said clamping mechanism further comprising an angular clamping block having a shape complementary to said corner region of the cutting blade, whereby a first portion (F 1a) of the clamping force is directed to and effects a clamping of the cutting blade against said radial seating surface and a second portion (F 1b) of the clamping force is directed to and effects a clamping of the cutting blade against said tangential seating surface, characterised in that a spacing is provided between the angular clamping block and both the surfaces of the slot other than the radial and tangential seating surfaces (14, 18).
Watch comprising a middle part which, with a crystal, delimits a watch case, the crystal comprising a top face oriented towards the user and an opposite bottom face oriented towards the watch case, a digital display device being fixed to the bottom face of the crystal, a printed circuit board being disposed inside the watch case, underneath and remote from the digital display device, the digital display device being electrically connected to the printed circuit board by means of a zebra-type electrical connector, the crystal abutting on a shoulder arranged in the middle part, the watch being characterised in that the shoulder protrudes from the middle part so that, before ultrasonic welding of the crystal on the middle part, the crystal is not in contact in its final position with the crystal, the height of the shoulder with respect to the printed circuit board being so that, when the shoulder is consumed during the ultrasonic welding, the zebra connector is compressed between the digital display device and the printed circuit board.
A nutraceutical composition for skin care, comprising: - Organic inulin and oligofructose in 2:1 ratio in a range of 34.4% to 55% w/w; - Probiotics in a range of 13.76% to 30% w/w; - L-Citrulline in a range of 17.20% to 25% w/w; - Pomegranate extracts in a range of 8.60% to 20% w/w; - Pine bark extract of 98% soluble grade in a range of 2.41% to 6% w/w; - Organic beet root extract in a range of 3.44% to 10% w/w; - L-Arginine in a range of 1.72% to 3% w/w; - Organic watermelon rind extract in a range of 0.69% to 10% w/w; - Vitamin K2 in a range of 0.28% to 2% w/w; - Vitamin D3 in a range of 0.10% to 0.45% w/w. - Organic inulin and oligofructose in 2:1 ratio in a range of 34.4% to 55% w/w; - Probiotics in a range of 13.76% to 30% w/w; - L-Citrulline in a range of 17.20% to 25% w/w; - Pomegranate extracts in a range of 8.60% to 20% w/w; - Pine bark extract of 98% soluble grade in a range of 2.41% to 6% w/w; - Organic beet root extract in a range of 3.44% to 10% w/w; - L-Arginine in a range of 1.72% to 3% w/w; - Organic watermelon rind extract in a range of 0.69% to 10% w/w; - Vitamin K2 in a range of 0.28% to 2% w/w; - Vitamin D3 in a range of 0.10% to 0.45% w/w.
An antibody for use in the treatment of rheumatoid arthritis in a subject, wherein the subject was previously ineffectively treated for rheumatoid arthritis with at least one disease-modifying anti-rheumatic drug (DMARD), wherein the at least one DMARD is selected from the group consisting of methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, abatacept, rituximab, tocilizumab, adalimumab, certolizumab pegol, etanercept, golimumab and infliximab, wherein the antibody comprises the heavy chain variable region of sequence SEQ ID NO:1 and the light chain variable region sequence of SEQ ID NO:2, wherein the antibody is administered in an amount of 150 mg or 200 mg per every two weeks and methotrexate is administered in an amount of 6 to 25 mg per week, and wherein the use of the antibody improves the subject's Health-Related Quality of Life, wherein the improvement in Health-Related Quality of Life is characterized by: (i) a change from baseline in Short Form-36 Mental Health (SF-36 MH) of at least 5, and (ii) a change from BL in Short Form-36 Mental Component Summary (SF-36 MCS) of at least 2.5 after 24 weeks of treatment with the antibody. (i) a change from baseline in Short Form-36 Mental Health (SF-36 MH) of at least 5, and (ii) a change from BL in Short Form-36 Mental Component Summary (SF-36 MCS) of at least 2.5
A component mounting device for picking up a component supplied from a component supply device, transporting the component to a specified position on a board, and mounting the component on the board, the component mounting device comprising: an XY robot; a Z-axis slider attached to a slider of the XY robot so as to be movable in a Z-axis direction; a head loaded on the Z-axis slider; a nozzle attached to the head so as to be movable in the Z-axis direction; a first wiring tube connected to a device loaded on a slider of the XY robot, the first wiring tube moving in accordance with operation of the slider; a second wiring tube connected to a device loaded on the Z-axis slider, the second wiring tube moving in accordance with operation of the Z-axis slider; and a flexible section in which at least a portion of the first wiring tube and at least a portion of the second wiring tube are bundled, the flexible section being capable of expanding and contracting in a movement direction of the Z-axis slider and a movement direction of the slider of the XY robot. an XY robot; a Z-axis slider attached to a slider of the XY robot so as to be movable in a Z-axis direction; a head loaded on the Z-axis slider; a nozzle attached to the head so as to be movable in the Z-axis direction; a first wiring tube connected to a device loaded on a slider of the XY robot, the first wiring tube moving in accordance with operation of the slider; a second wiring tube connected to a device loaded on the Z-axis slider, the second wiring tube moving in accordance with operation of the Z-axis slider; and a flexible section in which at least a portion of the first wiring tube and at least a portion of the second wiring tube are bundled, the flexible section being capable of expanding and contracting in a movement direction of the Z-axis slider and a movement direction of the slider of the XY robot.
In vitro method for the diagnosis of primary sclerosing cholangitis by detection of autoantibodies from a sample that bind to one or more isoforms of Glycoprotein 2, comprising - providing a sample of a subject exhibiting symptoms and/or suspected of having primary sclerosing cholangitis, - providing two or more isoforms of Glycoprotein 2, wherein at least one of isoforms 1 and/or 2 and at least one of isoforms 3 and/or 4 are provided, wherein the amino acid sequences of isoforms 1, 2, 3 and 4 are according to SEQ ID NO 1, 2, 3 and 4, respectively, or amino acid sequences of more than 80%, more than 85%, more than 90% or more preferably more than 95% sequence identity to sequences of SEQ ID NO 1, 2, 3 and 4, - contacting said sample with said GP2 isoforms, and - detecting autoantibodies from said sample that bind to said one or more isoforms - wherein the contacting and detecting steps comprise: allowing autoantibodies in said sample to bind to more than one of said GP2 isoforms, thereby forming a complex (GP2-autoantibody complex), contacting said complex with a label to form a labeled complex; and detecting the presence or absence of the labeled complex for said GP2 isoforms, and associating the presence of the detected autoantibodies in the sample with the presence of primary sclerosing cholangitis. - providing a sample of a subject exhibiting symptoms and/or suspected of having primary sclerosing cholangitis, - providing two or more isoforms of Glycoprotein 2, wherein at least one of isoforms 1 and/or 2 and at least one of isoforms 3 and/or 4 are provided, wherein the amino acid sequences of isoforms 1, 2, 3 and 4 are according to SEQ ID NO 1, 2, 3 and 4, respectively, or amino acid sequences of more than 80%, more than 85%, more than 90% or more preferably more than 95% sequence identity to sequences of SEQ ID NO 1, 2, 3 and 4, - contacting said sample with said GP2 isoforms, and - detecting autoantibodies from said sample that bind to said one or more isoforms - wherein the contacting and detecting steps comprise: allowing autoantibodies in said sample to bind to more than one of said GP2 isoforms, thereby forming a complex (GP2-autoantibody complex), contacting said complex with a label to form a labeled complex; and detecting the presence or absence of the labeled complex for said GP2 isoforms, and associating the presence of the detected autoantibodies in the sample with the presence of primary sclerosing cholangitis.
A pinch valve arrangement arranged to be used in a hydraulic circuit, the pinch valve arrangement comprising: - an at least sectionally deformable fluid line, - a pinching unit comprising an engagement element that is arranged to engage and deform a defined valve portion of the fluid line for controlling a fluid flow through the fluid line, and - an engagement protrusion at the engagement element, wherein the engagement protrusion occupies a subsection of a longitudinal extension of the engagement element, wherein a main extension direction of the engagement protrusion is perpendicular to the longitudinal dimension of the engagement element, characterized in that the engagement element further comprises an offset section that is rearwardly displaced from the engagement protrusion, and wherein the engagement protrusion is arranged at a downstream end of the engagement element, wherein the offset section is arranged as a disengagement aid, and wherein, in an engaged state of the engagement element, a deformation of the valve portion at a pressurized side thereof urges the offset section and thus the engagement element into a disengaged state. - an at least sectionally deformable fluid line, - a pinching unit comprising an engagement element that is arranged to engage and deform a defined valve portion of the fluid line for controlling a fluid flow through the fluid line, and - an engagement protrusion at the engagement element, wherein the engagement protrusion occupies a subsection of a longitudinal extension of the engagement element, wherein a main extension direction of the engagement protrusion is perpendicular to the longitudinal dimension of the engagement element, characterized in that the engagement element further comprises an offset section that is rearwardly displaced from the engagement protrusion, and wherein the engagement protrusion is arranged at a downstream end of the engagement element, wherein the offset section is arranged as a disengagement aid, and wherein, in an engaged state of the engagement element, a deformation of the valve portion at a pressurized side thereof urges the offset section and thus the engagement element into a disengaged state. wherein the engagement protrusion occupies a subsection of a longitudinal extension of the engagement element, wherein a main extension direction of the engagement protrusion is perpendicular to the longitudinal dimension of the engagement element, characterized in that the engagement element further comprises an offset section that is rearwardly displaced from the engagement protrusion, and wherein the engagement protrusion is arranged at a downstream end of the engagement element, wherein the offset section is arranged as a disengagement aid, and wherein, in an engaged state of the engagement element, a deformation of the valve portion at a pressurized side thereof urges the offset section and thus the engagement element into a disengaged state.
A wiper device which controls a duty ratio in accordance with a target rotation speed instructed by an operation of a wiper switch and causes a wiper member (15a, 15b) to perform a wiping operation using a motor, comprising: a boost control unit which varies an advance angle and an energization angle associated with energization of the motor in accordance with the target rotation speed in a case in which the duty ratio has reached a predetermined upper limit value and a rotation speed of the motor is less than the target rotation speed; the wiper device being characterized by a temperature sensor which detects a temperature of the motor; a first protection unit which monitors a load state of the motor and performs a first protection control for decreasing the rotational speed of the motor when a high-load state of the motor is detected; and a second protection unit which performs a second protection control for fixing the advance angle and energization angle of the motor by prohibiting an operation of the boost control unit when a first condition has been satisfied and the temperature detected by the temperature sensor exceeds a first threshold while the first protection control is being performed, wherein the first condition refers to reception of an operation signal from the wiper switch. a boost control unit which varies an advance angle and an energization angle associated with energization of the motor in accordance with the target rotation speed in a case in which the duty ratio has reached a predetermined upper limit value and a rotation speed of the motor is less than the target rotation speed; the wiper device being characterized by a temperature sensor which detects a temperature of the motor; a first protection unit which monitors a load state of the motor and performs a first protection control for decreasing the rotational speed of the motor when a high-load state of the motor is detected; and a second protection unit which performs a second protection control for fixing the advance angle and energization angle of the motor by prohibiting an operation of the boost control unit when a first condition has been satisfied and the temperature detected by the temperature sensor exceeds a first threshold while the first protection control is being performed, wherein the first condition refers to reception of an operation signal from the wiper switch.
A box-shaped UV disinfection system (100; 200; 500; 600) having at least a displaceable wall and comprising a plurality of discrete UV sources (121, 122, 131, 132, 141, 142; 221, 222, 223, 241, 242, 243; 521, 522, 531, 532) disposed therein, but not present on at least one of the walls, and an internal UV-transmitting support (101; 201; 501, 501', 501", 501′′′; 601, 601', 601", 601′′′), wherein all of the internal wall surfaces have a reflectance higher than 80% and preferably higher than 87% in the wavelengths range between 250 and 350 nm, said discrete UV sources (121, 122, 131, 132, 141, 142; 221, 222, 223, 241, 242, 243; 521, 522, 531, 532) are disposed on at least two of its walls (110, 120, 130, 140, 150, 160; 210, 220, 230, 240; 510, 520, 530) that are adjacent to each other, and said UV-transmitting support (101; 201; 501, 501', 501", 501′′′; 601, 601', 601", 601′′′) has at least a 70% UV transmittance in the wavelengths range between 250 and 350 nm and is located at a minimum distance d1 from a base wall (110; 210; 510) and at a maximum distance d2 from an opposite upper wall (120; 220; 520) such that 0.1≤d1/(d1+d2)<0.5, and preferably 0.15≤d1/(d1+d2)<0.4, characterized in that the discrete UV sources (131, 132, 141, 142; 241, 242, 243; 531, 532) disposed on at least one of the walls (130, 140; 240; 530) are inclined towards the base wall (110; 210; 510) with an angle comprised between 5° and 30°.
A rocket engine, comprising a thrust chamber for the fuel combustion and a nozzle expansion for the exiting of the fuel, with a heat shield which is arranged between the thrust chamber and the nozzle expansion, wherein the heat shield comprises: a first planar element having a front and a back side (2a, 2b); wherein, in a mounted state of the heat shield, the first planar element extends outwards from the rocket engine, with its front side being exposed to the heat radiation of at least a section of the nozzle expansion; characterized in that a second insulating planar element having a front and a back side (3a, 3c) is arranged on the back side of the first planar element in such a manner that a space is formed between the back side of the first planar element and the front side of the second planar element, wherein, in the mounted state of the heat shield, the gap widens in an outward direction from the rocket engine. a first planar element having a front and a back side (2a, 2b); wherein, in a mounted state of the heat shield, the first planar element extends outwards from the rocket engine, with its front side being exposed to the heat radiation of at least a section of the nozzle expansion; characterized in that a second insulating planar element having a front and a back side (3a, 3c) is arranged on the back side of the first planar element in such a manner that a space is formed between the back side of the first planar element and the front side of the second planar element, wherein, in the mounted state of the heat shield, the gap widens in an outward direction from the rocket engine.