An Optical Coherence Tomography, OCT, imaging system, comprising: an OCT light source operable to emit an OCT light beam, a sample arm waveguide (108; 508; 608; 708) and a reference arm waveguide (106; 506; 606; 706), and a beam splitter operable to split the OCT light beam into a sample beam delivered to the sample arm waveguide (108; 508; 608; 708), and a reference beam delivered to the reference arm waveguide (106; 506; 606; 706), characterized by a cladding (523; 623; 729) coupling the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706) together, wherein the cladding (523; 623; 729) is conformally disposed over the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706), for improving a calibration of a generated OCT image by minimizing axial movement of the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706) relative to one another, wherein the reference arm waveguide (106; 506; 606) comprises a first core (521; 621) surrounded by the cladding (523; 623), and the sample arm waveguide (108; 508; 608) comprises a second core (525; 625) surrounded by the cladding (523; 623), and wherein a buffer is disposed over the cladding (523; 623), or wherein the reference arm waveguide comprises a first core surrounded by a first section of a first additional cladding concentrically disposed over the first core, and the sample arm waveguide comprises a second core, separate from the first core, wherein the second core is surrounded by a second section of a second additional cladding concentrically disposed over the second core, and wherein a buffer serving as the cladding is disposed over the first section of the first additional cladding and the second section of the second additional cladding, and wherein the reference arm waveguide (106; 506; 606; 706) and the sample arm waveguide (108; 508; 608; 708) are glass, and wherein the buffer (529; 629; 729) is a polymer. an OCT light source operable to emit an OCT light beam, a sample arm waveguide (108; 508; 608; 708) and a reference arm waveguide (106; 506; 606; 706), and a beam splitter operable to split the OCT light beam into a sample beam delivered to the sample arm waveguide (108; 508; 608; 708), and a reference beam delivered to the reference arm waveguide (106; 506; 606; 706), characterized by a cladding (523; 623; 729) coupling the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706) together, wherein the cladding (523; 623; 729) is conformally disposed over the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706), for improving a calibration of a generated OCT image by minimizing axial movement of the sample arm waveguide (108; 508; 608; 708) and the reference arm waveguide (106; 506; 606; 706) relative to one another, wherein the reference arm waveguide (106; 506; 606) comprises a first core (521; 621) surrounded by the cladding (523; 623), and the sample arm waveguide (108; 508; 608) comprises a second core (525; 625) surrounded by the cladding (523; 623), and wherein a buffer is disposed over the cladding (523; 623), or wherein the reference arm waveguide comprises a first core surrounded by a first section of a first additional cladding concentrically disposed over the first core, and the sample arm waveguide comprises a second core, separate from the first core, wherein the second core is surrounded by a second section of a second additional cladding concentrically disposed over the second core, and wherein a buffer serving as the cladding is disposed over the first section of the first additional cladding and the second section of the second additional cladding, and wherein the reference arm waveguide (106; 506; 606; 706) and the sample arm waveguide (108; 508; 608; 708) are glass, and wherein the buffer (529; 629; 729) is a polymer.