mhurhangee/ep-ind-claims huggingface dataset:
A process for the preparation of a coated particle comprising the steps of: i) providing a core comprising at least one active pharmaceutical ingredient, ii) providing an intermediate layer onto said core, iii) providing a first enteric coating layer onto said intermediate layer by applying an aqueous dispersion of an enteric polymer onto said intermediate layer, iv) providing a second enteric coating layer onto said first enteric coating layer by applying an organic solution of an enteric polymer onto said first enteric layer, wherein said organic solution comprises one or more fatty acids and one or more emulsifiers and hydrophilic plasticizer, wherein said hydrophilic plasticizer is propylene glycol, and v) obtaining said coated particle, wherein the enteric polymer used in step iii) and iv) is an anionic polymer or copolymer. i) providing a core comprising at least one active pharmaceutical ingredient, ii) providing an intermediate layer onto said core, iii) providing a first enteric coating layer onto said intermediate layer by applying an aqueous dispersion of an enteric polymer onto said intermediate layer, iv) providing a second enteric coating layer onto said first enteric coating layer by applying an organic solution of an enteric polymer onto said first enteric layer, wherein said organic solution comprises one or more fatty acids and one or more emulsifiers and hydrophilic plasticizer, wherein said hydrophilic plasticizer is propylene glycol, and v) obtaining said coated particle,
Measurement circuit of an electrical magnitude at the terminals of a switching element having a first terminal at an upstream potential and a second terminal at a downstream potential, the measurement circuit comprising a device for differential processing of the upstream and downstream potentials supplied by a supply device, characterised by the fact that the supply device operates only on the closure of the switching element, a protection device of the upstream potential between the said first terminal and a first input of the differential processing device controlled by a switching device of the upstream potential providing the supply of the said first input only when the switching element is closed and a downstream protection device between the said second terminal and a second input of the differential processing device controlled directly by the closure of the switching element providing the supply of the said second input.
A radiation detector, comprising: a scintillator; a photosensor optically coupled to the scintillator; and an electronics module with a current-to-frequency converter, which comprises a charge integrator and a comparator, for integrating and converting a charge generated by the photosensor during a measurement cycle into a pulsed signal having a frequency correlating with the charge; wherein the electronics module comprises a current source for supplying a bias current to the current-to-frequency converter and for generating a frequency offset of the pulsed signal; wherein the electronics module comprises an interrupting device for interrupting an integration of the charge by the charge integrator; wherein the electronics module comprises a logic module for determining the frequency of the pulsed signal; and wherein the logic module is configured for determining an off-state of a radiation source and for triggering the interrupting device upon determining the off-state of the radiation source. a scintillator; a photosensor optically coupled to the scintillator; and an electronics module with a current-to-frequency converter, which comprises a charge integrator and a comparator, for integrating and converting a charge generated by the photosensor during a measurement cycle into a pulsed signal having a frequency correlating with the charge; wherein the electronics module comprises a current source for supplying a bias current to the current-to-frequency converter and for generating a frequency offset of the pulsed signal; wherein the electronics module comprises an interrupting device for interrupting an integration of the charge by the charge integrator; wherein the electronics module comprises a logic module for determining the frequency of the pulsed signal; and wherein the logic module is configured for determining an off-state of a radiation source and for triggering the interrupting device upon determining the off-state of the radiation source.
A steam station comprising an iron and a base station, in which the base station comprises a fluid reservoir and a filling port for water to be provided in to the fluid reservoir; the iron includes a filling funnel having a funnel inlet and a funnel outlet in fluid communication with the filling port, when the iron is positioned on the base station.
A fuel composition comprising: (a) at least 50 weight percent of a middle distillate fuel comprising from 0.5% to 30% by weight fatty acid methyl esters, relative to the total amount of the fuel composition; and (b) less than 50 weight percent of an additive composition comprising an antioxidant system comprising at least one cyclic amine antioxidant and at least one phenolic antioxidant, and at least one ashless dispersant, wherein - the at least one ashless dispersant is a hydrocarbyl-substituted succinimide which is present in the fuel composition in an amount of 60 ppm to 300 ppm; - the cyclic amine antioxidant is N,N-dimethyl cyclohexamine; and - the phenolic antioxidant is a tertiary butyl phenol; and wherein in the fuel composition, the antioxidant system is present in an amount to deliver from 20 ppm to 100 ppm of the cyclic amine antioxidant and from 20 ppm to 100 ppm of the phenolic antioxidant. (a) at least 50 weight percent of a middle distillate fuel comprising from 0.5% to 30% by weight fatty acid methyl esters, relative to the total amount of the fuel composition; and (b) less than 50 weight percent of an additive composition comprising an antioxidant system comprising at least one cyclic amine antioxidant and at least one phenolic antioxidant, and at least one ashless dispersant, - the at least one ashless dispersant is a hydrocarbyl-substituted succinimide which is present in the fuel composition in an amount of 60 ppm to 300 ppm; - the cyclic amine antioxidant is N,N-dimethyl cyclohexamine; and - the phenolic antioxidant is a tertiary butyl phenol;
A rechargeable lithium battery, comprising: a cylindrical can having a volume of greater than or equal to 15 cm 3, an electrode assembly accommodated in the cylindrical can, and an electrolyte impregnated in the electrode assembly, wherein the electrolyte comprises: a non-aqueous organic solvent; a lithium salt; a first additive comprising a compound represented by Chemical Formula 1; and a second additive comprising a compound represented by Chemical Formula 2, a derivative thereof, and/or an adduct thereof, a content of the second additive is less than about 5 wt% based on 100 wt% of the electrolyte: wherein, in Chemical Formula 1, X 1 is a halogen atom; Y 1 and Y 2 are each independently O or S; R 1 and R 2 are each independently H, a halogen atom, a substituted or unsubstituted C1 to C10 alkyl group, a vinyl group, a substituted or unsubstituted C6 to C10 aryl group, or a substituted or unsubstituted C2 to C10 heteroaryl group comprising a hetero atom of N, O, or P; wherein, in Chemical Formula 2, Z is N or CH. a cylindrical can having a volume of greater than or equal to 15 cm 3, an electrode assembly accommodated in the cylindrical can, and an electrolyte impregnated in the electrode assembly, wherein the electrolyte comprises: a non-aqueous organic solvent; a lithium salt; a first additive comprising a compound represented by Chemical Formula 1; and a second additive comprising a compound represented by Chemical Formula 2, a derivative thereof, and/or an adduct thereof, a content of the second additive is less than about 5 wt% based on 100 wt% of the electrolyte: wherein, in Chemical Formula 1, X 1 is a halogen atom; Y 1 and Y 2 are each independently O or S; R 1 and R 2 are each independently H, a halogen atom, a substituted or unsubstituted C1 to C10 alkyl group, a vinyl group, a substituted or unsubstituted C6 to C10 aryl group, or a substituted or unsubstituted C2 to C10 heteroaryl group comprising a hetero atom of N, O, or P; wherein, in Chemical Formula 2, Z is N or CH. a non-aqueous organic solvent; a lithium salt; a first additive comprising a compound represented by Chemical Formula 1; and a second additive comprising a compound represented by Chemical Formula 2, a derivative thereof, and/or an adduct thereof, a content of the second additive is less than about 5 wt% based on 100 wt% of the electrolyte: wherein, in Chemical Formula 1, X 1 is a halogen atom; Y 1 and Y 2 are each independently O or S; R 1 and R 2 are each independently H, a halogen atom, a substituted or unsubstituted C1 to C10 alkyl group, a vinyl group, a substituted or unsubstituted C6 to C10 aryl group, or a substituted or unsubstituted C2 to C10 heteroaryl group comprising a hetero atom of N, O, or P; wherein, in Chemical Formula 2, Z is N or CH. X 1 is a halogen atom; Y 1 and Y 2 are each independently O or S; R 1 and R 2 are each independently H, a halogen atom, a substituted or unsubstituted C1 to C10 alkyl group, a vinyl group, a substituted or unsubstituted C6 to C10 aryl group, or a substituted or unsubstituted C2 to C10 heteroaryl group comprising a hetero atom of N, O, or P; wherein, in Chemical Formula 2, Z is N or CH.
A protein having affinity for an immunoglobulin and having two or more domains represented by SEQ ID NOS: 4 to 6, wherein in an amino acid sequence of at least one domain of the domains, one or more lysines are included, and, when a sequence of 6 amino acid residues in total including one amino acid residue on the C-terminal side and 5 amino acid residues on the N-terminal side at a site where two domains are ligated is defined as a ligation site sequence, the C-terminal lysine and lysine at position 4 in at least one of the ligation site sequences are deleted or substituted.
A flexible device having a longitudinal axis, comprising: a first elongate member configured to move the flexible device in a first direction relative to the longitudinal axis; a second elongate member configured to move the flexible device in a second direction relative to the longitudinal axis that is different to the first direction; an articulation section including a plurality of articulation links, wherein at least one of the plurality of articulation links includes a body configured to receive the first elongate member and the second elongate member, the body defines a first lumen configured to receive the first elongate member, and the body defines a second lumen configured to receive the second elongate member, the second lumen being located generally opposite the first lumen; characterized by a cinching element (150, 150a) located within the first lumen, configured to engage the first elongate member to substantially limit movement between the plurality of articulation links when a tensile force is applied to the first elongate member and configured to disengage the first elongate member to permit movement between the plurality of articulation links when a tensile force is applied to the second elongate member. a first elongate member configured to move the flexible device in a first direction relative to the longitudinal axis; a second elongate member configured to move the flexible device in a second direction relative to the longitudinal axis that is different to the first direction; an articulation section including a plurality of articulation links, wherein at least one of the plurality of articulation links includes a body configured to receive the first elongate member and the second elongate member, the body defines a first lumen configured to receive the first elongate member, and the body defines a second lumen configured to receive the second elongate member, the second lumen being located generally opposite the first lumen; characterized by a cinching element (150, 150a) located within the first lumen, configured to engage the first elongate member to substantially limit movement between the plurality of articulation links when a tensile force is applied to the first elongate member and configured to disengage the first elongate member to permit movement between the plurality of articulation links when a tensile force is applied to the second elongate member.
A transportable container, of the type of a trolley case, suitcase, trunk, backpack, and the like, which comprises at least one shell, which delimits an inner compartment for accommodating items of clothing and other objects, and at least one handle, which can be gripped by a user, the container further comprising at least one removable means of interlocking said handle with at least one respective abutment, which is associated with said shell, said at least one removable interlocking means comprising at least one hook, which is anchored to said at least one handle and which can removably engage by interlocking with said at least one abutment, the container further comprising at least one pair of wheels, which are rotatably supported by a respective shaft, which is fixed to said shell, said at least one hook being engaged by interlocking with respective portions of said shaft, constituting said abutment.
A process for recovering wastes of a polymeric composition including at least one peroxide-curable polymer and at least one peroxidic crosslinking agent, which comprises compounding the wastes with at least one antioxidant agent suitable for sulfur-vulcanized elastomeric compositions, at a temperature lower than the decomposition temperature of the at least one peroxide crosslinking agent; wherein the at least one antioxidant agent is selected from: secondary phenylamines, and low molecular weight hindered phenols having a molecular weight lower than 1000; wherein the method includes the use of the recovered polymeric composition as filling material for electrical cable cores. secondary phenylamines, and low molecular weight hindered phenols having a molecular weight lower than 1000; wherein the method includes the use of the recovered polymeric composition as filling material for electrical cable cores.
A method of sampling and analyzing seed tissue for genotyping of seeds while maintaining germination capacity, comprising the following steps: - having one or more seeds to genotype, - optionally soaking the seed with water to soften it and enable the next step, - manually or semi-automatically collecting a determined volume of sample from the albumen or cotyledon of the seed(s), using an outline cutter designed to cut, carry away and then release a determined volume of tissue, this volume being determined to allow the analysis of at least one constituent of the seed(s), - placing the tissue sample from a single seed or multiple seeds into an identified, traceable well, - performing the genotyping analysis on the contents of the well(s). - determining the sample(s) with the desired genomic trait(s), optionally sow the selected seed(s) corresponding to those samples that have the desired genomic trait(s). - having one or more seeds to genotype, - optionally soaking the seed with water to soften it and enable the next step, - manually or semi-automatically collecting a determined volume of sample from the albumen or cotyledon of the seed(s), using an outline cutter designed to cut, carry away and then release a determined volume of tissue, this volume being determined to allow the analysis of at least one constituent of the seed(s), - placing the tissue sample from a single seed or multiple seeds into an identified, traceable well, - performing the genotyping analysis on the contents of the well(s). - determining the sample(s) with the desired genomic trait(s), optionally sow the selected seed(s) corresponding to those samples that have the desired genomic trait(s).
A compound of formula (I-g) or a pharmaceutically acceptable salt thereof wherein R 4 is hydrogen or alkyl; L is -[C(R a R b)] p -; A 1 is Cyc 2 -Q-Cyc 3; R a and R b are each independently hydrogen or alkyl; p is 0 or 1; Cyc 2 is aryl or heteroaryl; Q is a bond; Cyc 3 is heteroaryl; M is a bond or -[C(R c R d)] t -[C(R e R f)] k -; A 2 is heterocycle or cycloalkyl; R c, R d, R e, and R f are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently unsubstituted or substituted with substituents independently selected from halogen, =O (oxo), =S (thioxo), cyano, nitro, alkoxyfluoroalkyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, alkylamino, acylamino, aminoalkyl, alkylsulfonyl, aminosulfonyl, -COOH, and acyl. R 4 is hydrogen or alkyl; L is -[C(R a R b)] p -; A 1 is Cyc 2 -Q-Cyc 3; R a and R b are each independently hydrogen or alkyl; p is 0 or 1; Cyc 2 is aryl or heteroaryl; Q is a bond; Cyc 3 is heteroaryl; M is a bond or -[C(R c R d)] t -[C(R e R f)] k -; A 2 is heterocycle or cycloalkyl; R c, R d, R e, and R f are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently unsubstituted or substituted with substituents independently selected from halogen, =O (oxo), =S (thioxo), cyano, nitro, alkoxyfluoroalkyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, alkylamino, acylamino, aminoalkyl, alkylsulfonyl, aminosulfonyl, -COOH, and acyl.
An apparatus for monitoring one or more target objects in an environment external to a host vehicle by means of at least one sensor, the apparatus being arranged to trigger at least one action responsive to the detection of prescribed relative movement between the host vehicle and the one or more target objects, wherein the apparatus is arranged to monitor one or more control inputs (141, 121 P, 130P) of the host vehicle and to over-ride triggering of the at least one action in dependence on a rate of change of the control input (141, 121P, 130P) such that triggering of the at least one action is not performed in the event that the rate of change exceeds a predetermined threshold.
A double-stranded small interfering RNA (siRNA) or chemically modified siRNA thereof, which targets a nucleotide sequence region of PRK2 mRNA set forth in SEQ ID NO: 1, wherein the siRNA consists of a guide strand sequence set forth in SEQ ID NO: 2 and a passenger strand sequence set forth in SEQ ID NO: 3; and the chemically modified siRNA consists of a guide strand having the base sequence set forth in SEQ ID NO: 4 or 5 and a passenger strand having the base sequence set forth in SEQ ID NO: 3, 9 or 10.
A tablet composition comprising a) a therapeutically effective dose of cinacalcet hydrochloride having a particle size distribution D 90 equal to or less than 30 μm in an amount of from 45% to 55% by weight based on the total weight of the composition, b) pregelatinized starch in an amount of from 30% to 50% by weight based on the total weight of the composition; and c) At least one binder in an amount of from 1% to 5% by weight based on the total weight of the composition. a) a therapeutically effective dose of cinacalcet hydrochloride having a particle size distribution D 90 equal to or less than 30 μm in an amount of from 45% to 55% by weight based on the total weight of the composition, b) pregelatinized starch in an amount of from 30% to 50% by weight based on the total weight of the composition; and c) At least one binder in an amount of from 1% to 5% by weight based on the total weight of the composition.
A process of reforming a liquid fuel comprising from greater than 50 ppm w sulfur to less than 400 ppm w sulfur, the process comprising contacting a liquid hydrocarbon fuel comprising one or more organosulfur compounds in a concentration from greater than 50 ppm w to less than 400 ppm w sulfur with an oxidant and steam or water, the contacting occurring in a catalyst bed comprising a reforming catalyst deposited on an ultra-short-channel-length metal substrate, having a channel length in the range from 25 μm to 500 μm, such that the process is conducted at a peak catalyst temperature greater than 950°C so as to produce a reformate mixture comprising hydrogen and carbon monoxide, wherein the peak catalyst temperature is maintained at a distance from greater than 5 percent to less than 50 percent along the length of the catalyst bed as measured from inlet to outlet.
A system, comprising: a lead configured to deliver electrical stimulation to a brain of a patient, the lead comprising a housing defining a longitudinal axis and a circumference, a plurality of electrodes disposed at respective different positions around the circumference of the lead housing, and a marker at a circumferential location that identifies a circumferential orientation of the lead; a user interface; and a processor configured to present on the user interface at least one view of a representation of the lead comprising a representation of the marker, to receive user input to position the representation of the lead and further rotate said representation so that the representation of the marker corresponds to an orientation of the lead within a patient, and to receive user interaction with the at least one view to define stimulation to be delivered by the lead to the patient. a lead configured to deliver electrical stimulation to a brain of a patient, the lead comprising a housing defining a longitudinal axis and a circumference, a plurality of electrodes disposed at respective different positions around the circumference of the lead housing, and a marker at a circumferential location that identifies a circumferential orientation of the lead; a user interface; and a processor configured to present on the user interface at least one view of a representation of the lead comprising a representation of the marker, to receive user input to position the representation of the lead and further rotate said representation so that the representation of the marker corresponds to an orientation of the lead within a patient, and to receive user interaction with the at least one view to define stimulation to be delivered by the lead to the patient.