A gas enclosure system comprising: a gas enclosure comprising: a printing system enclosure defining a first volume, the printing system enclosure being operably coupled to an environmental control system, the environmental control system being configured to provide a controlled processing environment for the first volume; an auxiliary enclosure defining a second volume, the auxiliary enclosure being operably coupled to the environmental control system, the environmental control system being configured to provide a controlled processing environment for the second volume; wherein the gas enclosure has a first sealable opening between the printing system enclosure and the auxiliary enclosure and a second sealable opening between to the auxiliary enclosure from the exterior of the gas enclosure; an industrial printing system housed within the printing system enclosure comprising: a printhead assembly comprising at least one printhead device; a substrate support apparatus for supporting a substrate; and a motion system for the relative positioning of the printhead assembly with respect to the substrate; and a handler located in the gas enclosure, wherein the location of the handler is proximal the first sealable opening, the handler being configured to move objects between the printing system enclosure and the auxiliary enclosure; and a printhead management system housed within the auxiliary enclosure. a gas enclosure comprising: a printing system enclosure defining a first volume, the printing system enclosure being operably coupled to an environmental control system, the environmental control system being configured to provide a controlled processing environment for the first volume; an auxiliary enclosure defining a second volume, the auxiliary enclosure being operably coupled to the environmental control system, the environmental control system being configured to provide a controlled processing environment for the second volume; wherein the gas enclosure has a first sealable opening between the printing system enclosure and the auxiliary enclosure and a second sealable opening between to the auxiliary enclosure from the exterior of the gas enclosure; a printing system enclosure defining a first volume, the printing system enclosure being operably coupled to an environmental control system, the environmental control system being configured to provide a controlled processing environment for the first volume; an auxiliary enclosure defining a second volume, the auxiliary enclosure being operably coupled to the environmental control system, the environmental control system being configured to provide a controlled processing environment for the second volume; wherein the gas enclosure has a first sealable opening between the printing system enclosure and the auxiliary enclosure and a second sealable opening between to the auxiliary enclosure from the exterior of the gas enclosure; an industrial printing system housed within the printing system enclosure comprising: a printhead assembly comprising at least one printhead device; a substrate support apparatus for supporting a substrate; and a motion system for the relative positioning of the printhead assembly with respect to the substrate; and a printhead assembly comprising at least one printhead device; a substrate support apparatus for supporting a substrate; and a motion system for the relative positioning of the printhead assembly with respect to the substrate; and a handler located in the gas enclosure, wherein the location of the handler is proximal the first sealable opening, the handler being configured to move objects between the printing system enclosure and the auxiliary enclosure; and a printhead management system housed within the auxiliary enclosure.