A computer-implemented method for exploration of medical visualization parameters in virtual spaces, the method comprising: detecting a user location and a user orientation in a physical space; generating a display of an immersive layout centered at the user location and the user orientation; generating a plurality of holograms within in the immersive layout, wherein each hologram depicts a rendering of a medical image with a distinct combination of rendering parameter values, wherein each hologram is generated using a pre-rendered point cloud-based proxy, a mesh-based proxy, or a light field located in the immersive layout and each hologram provides a photorealistic rendering of the medical image generated using one or more Monte Carlo ray tracing techniques, wherein the display is updated based on a change to one or more of the user location and the user orientation in the physical space, wherein each hologram depicts a rendering of a medical image with a distinct combination of rendering parameter values; and updating the display based on a change to one or more of the user location and the user orientation in the physical space, wherein the method further comprises: receiving a selection of a parameter space comprising all possible combinations of values for a plurality of image rendering system parameters; identifying a plurality of distinct combination of values in the parameter space; determining positional coordinates in a multi-dimensional virtual space for each distinct combination of values in the parameter space based on a mapping of the parameter space to the multi-dimensional virtual space; generating a hologram for each distinct combination of values providing a rendering of a medical image with the distinct combination of values; displaying each hologram in an immersive layout within the multi-dimensional virtual space, wherein (i) the immersive layout is centered on a location corresponding to a user and (ii) each hologram is displayed at the positional coordinates corresponding to the distinct combination of values used to generate the hologram. detecting a user location and a user orientation in a physical space; generating a display of an immersive layout centered at the user location and the user orientation; generating a plurality of holograms within in the immersive layout, wherein each hologram depicts a rendering of a medical image with a distinct combination of rendering parameter values, wherein each hologram is generated using a pre-rendered point cloud-based proxy, a mesh-based proxy, or a light field located in the immersive layout and each hologram provides a photorealistic rendering of the medical image generated using one or more Monte Carlo ray tracing techniques, wherein the display is updated based on a change to one or more of the user location and the user orientation in the physical space, wherein each hologram depicts a rendering of a medical image with a distinct combination of rendering parameter values; and updating the display based on a change to one or more of the user location and the user orientation in the physical space, receiving a selection of a parameter space comprising all possible combinations of values for a plurality of image rendering system parameters; identifying a plurality of distinct combination of values in the parameter space; determining positional coordinates in a multi-dimensional virtual space for each distinct combination of values in the parameter space based on a mapping of the parameter space to the multi-dimensional virtual space; generating a hologram for each distinct combination of values providing a rendering of a medical image with the distinct combination of values; displaying each hologram in an immersive layout within the multi-dimensional virtual space, wherein (i) the immersive layout is centered on a location corresponding to a user and (ii) each hologram is displayed at the positional coordinates corresponding to the distinct combination of values used to generate the hologram.