A compound of formula: for use in the treatment and/or prevention of cancer wherein X and Y are each independently C or N; A is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl, wherein the one or more substituents on the aryl or heteroaryl are independently selected from unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, haloalkyl, halogen, OR A, SR A, S(=O)(=O)-R A, SO 2 NHR A, OC R B, C R B, NR A R B, OP (OR A) 2, NHC R A, COONR A R B, OS or wherein the one or more substituents on the C 1 -C 6 alkyl or on the C 2 -C 6 alkenyl or on the C 2 -C 6 alkynyl are independently selected from OR A, COOR B, OC R B, C R B, NR A R B, OP (OR A) 2, NHC R A, NHC OR A, COONR A R B, SR A, S(=O)(=O)-R A, SO 2 NHR A; R 1, R 2, R 3, R 4, R 6, R 7 and R 10 are each independently selected from H, halogen, alkoxy, C 1 -C 6 alkyl, haloalkyl, OR A, SR A, S(=O)(=O)-R A, SO 2 NHR A, COOR B, OC R B, NR A R B, OP (OR A) 2, NHC R A, COONR A R B, NO 2, CN; Z is a heteroaryl group selected from: or or wherein R 5 is H, unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted phenyl, wherein the one or more substituents on the C 1 -C 10 alkyl are independently selected from halogen, OR A, COOR B, OC R B, NR A R B, OP (OR A) 2, OC NR A R B, C R B, NHC OR A, NHC R A, COONR A R B, OC CHCHR C, R A and R B are each independently selected from H, substituted or unsubstituted C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, unsubstituted or substituted aralkyl, haloalkyl, or R A and R B together with the nitrogen to which they are attached, form a 4-7 membered saturated or partially unsaturated ring optionally containing one or more additional heteroatoms independently selected from N, S and O the ring being optionally substituted by one, two or more groups independently selected from halogen, C 1 -C 6 alkyl, haloalkyl, OH, alkoxy; R C is substituted or unsubstituted phenyl, 1,3 benzodioxolyl, wherein the one or more substituent(s) on the phenyl are independently selected from halogen, haloalkyl, alkoxy, C 1 -C 3 alkyl, or OH; R 5 and R 9 are each independently selected from H, halogen, alkoxy, COOH, nitro and at least one of R 8 and R 9 is a heteroaryl group selected from: or or or salt, solvate, stereoisomer thereof, provided that compounds: are excluded. X and Y are each independently C or N; A is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl, wherein the one or more substituents on the aryl or heteroaryl are independently selected from unsubstituted or substituted C 1 -C 6 alkyl, unsubstituted or substituted C 2 -C 6 alkenyl, unsubstituted or substituted C 2 -C 6 alkynyl, haloalkyl, halogen, OR A, SR A, S(=O)(=O)-R A, SO 2 NHR A, OC R B, C R B, NR A R B, OP (OR A) 2, NHC R A, COONR A R B, OS or wherein the one or more substituents on the C 1 -C 6 alkyl or on the C 2 -C 6 alkenyl or on the C 2 -C 6 alkynyl are independently selected from OR A, COOR B, OC R B, C R B, NR A R B, OP (OR A) 2, NHC R A, NHC OR A, COONR A R B, SR A, S(=O)(=O)-R A, SO 2 NHR A; R 1, R 2, R 3, R 4, R 6, R 7 and R 10 are each independently selected from H, halogen, alkoxy, C 1 -C 6 alkyl, haloalkyl, OR A, SR A, S(=O)(=O)-R A, SO 2 NHR A, COOR B, OC R B, NR A R B, OP (OR A) 2, NHC R A, COONR A R B, NO 2, CN; Z is a heteroaryl group selected from: or or wherein R 5 is H, unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted phenyl, wherein the one or more substituents on the C 1 -C 10 alkyl are independently selected from halogen, OR A, COOR B, OC R B, NR A R B, OP (OR A) 2, OC NR A R B, C R B, NHC OR A, NHC R A, COONR A R B, OC CHCHR C, R 5 is H, unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted phenyl, wherein the one or more substituents on the C 1 -C 10 alkyl are independently selected from halogen, OR A, COOR B, OC R B, NR A R B, OP (OR A) 2, OC NR A R B, C R B, NHC OR A, NHC R A, COONR A R B, OC CHCHR C, R A and R B are each independently selected from H, substituted or unsubstituted C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, unsubstituted or substituted aralkyl, haloalkyl, or R A and R B together with the nitrogen to which they are attached, form a 4-7 membered saturated or partially unsaturated ring optionally containing one or more additional heteroatoms independently selected from N, S and O the ring being optionally substituted by one, two or more groups independently selected from halogen, C 1 -C 6 alkyl, haloalkyl, OH, alkoxy; R C is substituted or unsubstituted phenyl, 1,3 benzodioxolyl, wherein the one or more substituent(s) on the phenyl are independently selected from halogen, haloalkyl, alkoxy, C 1 -C 3 alkyl, or OH; R 5 and R 9 are each independently selected from H, halogen, alkoxy, COOH, nitro and at least one of R 8 and R 9 is a heteroaryl group selected from: or or or salt, solvate, stereoisomer thereof, provided that compounds: are excluded.