A compound of formula, a pharmaceutically acceptable salt or solvate thereof: wherein, R 1 is phenyl, pyridyl or thienyl fused with a structural moiety which, together with two ring members of said phenyl, pyridyl or thienyl, forms a 5-7 membered aromatic or non-aromatic ring, wherein said ring optionally contains up to three heteroatoms independently selected from O, N and S, and the fused phenyl, pyridyl or thienyl ring is optionally substituted with one or more groups independently selected from halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 1-6 haloalkyl, CN, -(CH 2) p -OR 4, -O-(CH 2) q -NR 4 R 5, -(CH 2) p -NR 4 R 5, -NHCO-O-(CH 2) q -NR 4 R 5, -NHCO-(CH 2) p -NR 4 R 5, or -C 5-15 heteroaryl containg up to three heteroatoms independently selected from O, N and S; or R 1 is phenyl or pyridyl optionally substituted with one or more groups independently selected from halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 1-6 haloalkyl, -CN, -(CH 2) p -OR 4, -O-(CH 2) q -NR 4 R 5, -NH-(CH 2) q -NR 4 R 5, -(CH 2) p -NR 4 R 5, -(CH 2) p -NHCOR 4, -(CH 2) p -NHCO 2 R 4, -(CH 2) p -NHSO 2 R 4 or -C 5-15 heterocycle, said -C 5-15 heterocycle containg up to three heteroatoms independently selected from O, N and S and being optionally substituted with C 1-6 alkyl; R 2 is H, halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 3-7 cycloalkyl, -C 5-15 heteroaryl, -C 1-6 haloalkyl, -(CH 2) p -OR 4, -O-(CH 2) p -NR 4 R 5, -(CH 2) p -NR 4 R 5, CN, - CONHR 4, or -SO 2 NHR 4; R 3 is H, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 3-7 cycloalkyl, -(CH 2) p -NR 4 R 5, -O-(CH 2) q NR 4 R 5, -(CH 2) p -CONHOH, -(CH 2) p -CN, -(CH 2) p -CO 2 R 4,-(CH 2) p -CONR 4 R 5, -(CH 2) p -tetrazole, -(CH 2) p -COR 4, -(CH 2) q -(OR 6) 2, -(CH 2) p -OR 4, -(CH 2) p -CH=CH-CN, -(CH 2) p -CH=CH-CO 2 R 4, -(CH 2) p -CH=CH-CONR 4 R 5, -(CH 2) p -NHCOR 4, -(CH 2) p -NHCO 2 R 4, -(CH 2) p -NHSO 2 R 4, or -(CH 2) p -CH=CH-tetrazole; R 4 and R 5 are independently H or -C 1-6 alkyl; or R 4 and R 5, together with the nitrogen atom to which they are attached, form a 3 to 6-membered aromatic or non-aromatic ring, wherein said ring optionally contains up to three heteroatoms independently selected from O, N, and S; R 6 is -C 1-6 alkyl; p is an integer ranging from 0 to 4; q is an integer ranging from 2 to 5; n is an integer ranging from 1 to 3; X is NR 7; and R 7 is H, OH, -C 1-6 alkyl, -C 3-7 cycloalkyl, or -CO-C 1-6 alkyl. R 1 is phenyl, pyridyl or thienyl fused with a structural moiety which, together with two ring members of said phenyl, pyridyl or thienyl, forms a 5-7 membered aromatic or non-aromatic ring, wherein said ring optionally contains up to three heteroatoms independently selected from O, N and S, and the fused phenyl, pyridyl or thienyl ring is optionally substituted with one or more groups independently selected from halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 1-6 haloalkyl, CN, -(CH 2) p -OR 4, -O-(CH 2) q -NR 4 R 5, -(CH 2) p -NR 4 R 5, -NHCO-O-(CH 2) q -NR 4 R 5, -NHCO-(CH 2) p -NR 4 R 5, or -C 5-15 heteroaryl containg up to three heteroatoms independently selected from O, N and S; or R 1 is phenyl or pyridyl optionally substituted with one or more groups independently selected from halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 1-6 haloalkyl, -CN, -(CH 2) p -OR 4, -O-(CH 2) q -NR 4 R 5, -NH-(CH 2) q -NR 4 R 5, -(CH 2) p -NR 4 R 5, -(CH 2) p -NHCOR 4, -(CH 2) p -NHCO 2 R 4, -(CH 2) p -NHSO 2 R 4 or -C 5-15 heterocycle, said -C 5-15 heterocycle containg up to three heteroatoms independently selected from O, N and S and being optionally substituted with C 1-6 alkyl; R 2 is H, halo, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 3-7 cycloalkyl, -C 5-15 heteroaryl, -C 1-6 haloalkyl, -(CH 2) p -OR 4, -O-(CH 2) p -NR 4 R 5, -(CH 2) p -NR 4 R 5, CN, - CONHR 4, or -SO 2 NHR 4; R 3 is H, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -C 1-6 alkyl, -C 3-7 cycloalkyl, -(CH 2) p -NR 4 R 5, -O-(CH 2) q NR 4 R 5, -(CH 2) p -CONHOH, -(CH 2) p -CN, -(CH 2) p -CO 2 R 4,-(CH 2) p -CONR 4 R 5, -(CH 2) p -tetrazole, -(CH 2) p -COR 4, -(CH 2) q -(OR 6) 2, -(CH 2) p -OR 4, -(CH 2) p -CH=CH-CN, -(CH 2) p -CH=CH-CO 2 R 4, -(CH 2) p -CH=CH-CONR 4 R 5, -(CH 2) p -NHCOR 4, -(CH 2) p -NHCO 2 R 4, -(CH 2) p -NHSO 2 R 4, or -(CH 2) p -CH=CH-tetrazole; R 4 and R 5 are independently H or -C 1-6 alkyl; or R 4 and R 5, together with the nitrogen atom to which they are attached, form a 3 to 6-membered aromatic or non-aromatic ring, wherein said ring optionally contains up to three heteroatoms independently selected from O, N, and S; R 6 is -C 1-6 alkyl; p is an integer ranging from 0 to 4; q is an integer ranging from 2 to 5; n is an integer ranging from 1 to 3; X is NR 7; and R 7 is H, OH, -C 1-6 alkyl, -C 3-7 cycloalkyl, or -CO-C 1-6 alkyl.