mhurhangee/ep-ind-claims huggingface dataset:
A system for transdermal delivery of a hydrophilic anti-emetic agent from a pharmaceutical composition comprising: (i) an apparatus for facilitating transdermal delivery of a hydrophilic anti-emetic agent through skin of a subject, said apparatus comprising: a. an electrode cartridge comprising an array of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy of radio frequency to the electrodes when the electrodes are in vicinity of the skin, typically generating current flow or one or more sparks, enabling ablation of stratum corneum in an area beneath the electrode, thereby generating a plurality of micro-channels in an area on the skin of the subject; and (ii) a patch comprising at least one hydrophilic layer comprising at least one hydrophilic polymer and a therapeutically effective amount of the hydrophilic anti-emetic agent in a pharmaceutical composition, wherein the pharmaceutical composition is devoid of penetration enhancers, and wherein the patch is adapted to be applied to the skin after the micro-channels are generated. (i) an apparatus for facilitating transdermal delivery of a hydrophilic anti-emetic agent through skin of a subject, said apparatus comprising: a. an electrode cartridge comprising an array of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy of radio frequency to the electrodes when the electrodes are in vicinity of the skin, typically generating current flow or one or more sparks, enabling ablation of stratum corneum in an area beneath the electrode, thereby generating a plurality of micro-channels in an area on the skin of the subject; and a. an electrode cartridge comprising an array of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy of radio frequency to the electrodes when the electrodes are in vicinity of the skin, typically generating current flow or one or more sparks, enabling ablation of stratum corneum in an area beneath the electrode, thereby generating a plurality of micro-channels in an area on the skin of the subject; and (ii) a patch comprising at least one hydrophilic layer comprising at least one hydrophilic polymer and a therapeutically effective amount of the hydrophilic anti-emetic agent in a pharmaceutical composition, wherein the pharmaceutical composition is devoid of penetration enhancers, and wherein the patch is adapted to be applied to the skin after the micro-channels are generated.
A composition for air polishing the surface of hard dental tissue, the composition comprising at least: • an abrasive first powder suitable for polishing hard dental tissue, the first powder comprising sodium bicarbonate, calcium carbonate, glycine, a silicate, silica, silicon hydroxide, silicon carbide, powdered pumice stone, diamond powder, aluminum oxide, aluminum hydroxide, or a mixture of these compounds; • a second powder of a gelling agent selected from: poloxamers, hydroxypropylmethyl cellulose, methyl cellulose, carrageenans, and mixtures thereof; and • a third powder of a dental treatment agent, the dental treatment agent being a therapeutic agent or a coloring agent. • an abrasive first powder suitable for polishing hard dental tissue, the first powder comprising sodium bicarbonate, calcium carbonate, glycine, a silicate, silica, silicon hydroxide, silicon carbide, powdered pumice stone, diamond powder, aluminum oxide, aluminum hydroxide, or a mixture of these compounds; • a second powder of a gelling agent selected from: poloxamers, hydroxypropylmethyl cellulose, methyl cellulose, carrageenans, and mixtures thereof; and • a third powder of a dental treatment agent, the dental treatment agent being a therapeutic agent or a coloring agent.
A tractor comprising a drive unit (14, 18), a chassis with a front and a rear axle and a mounting device for a front loader, wherein the chassis includes a front frame portion to which the front axle is mounted and a rear frame portion which is spaced from the front frame portion and to which the rear axle is mounted, characterised in that the two frame portions are connected together by the drive unit (14, 18), wherein the drive unit (14, 18) includes an engine block and an oil sump, wherein the oil sump is fixed to the front and rear frame portions.
Airbag module for fixing on the underside of a rail vehicle between the rail vehicle and a track, comprising: a bracket for fixing the airbag module on the underside of the rail vehicle; a support flap with a front end and a rear end, wherein the rear end of the support flap is pivotably mounted by means of a first pivot bearing, wherein the airbag module is convertible from a closed state into an open state by pivoting the support flap, and the front end of the support flap thereby moves toward the track; a guide element with a front end and a rear end, wherein the front end of the guide element is pivotably mounted by means of a second pivot bearing and in an open state of the airbag module, the rear end of the guide element is pivoted toward the track; a third pivot bearing, which moveably connects the support flap and the guide element to each other; an airbag, fixed on the airbag module, in particular on the support flap and/or on the bracket, folded in the closed state of the airbag module and unfolded in the open state of the airbag module, and which projects past the front end of the support flap in its unfolded state, so that the unfolded airbag and the support flap together form an impact protection for a person on the track; wherein a pivot bearing, selected from the group consisting of the first pivot bearing, the second pivot bearing, and the third pivot bearing, is a displaceable pivot bearing. a bracket for fixing the airbag module on the underside of the rail vehicle; a support flap with a front end and a rear end, wherein the rear end of the support flap is pivotably mounted by means of a first pivot bearing, wherein the airbag module is convertible from a closed state into an open state by pivoting the support flap, and the front end of the support flap thereby moves toward the track; a guide element with a front end and a rear end, wherein the front end of the guide element is pivotably mounted by means of a second pivot bearing and in an open state of the airbag module, the rear end of the guide element is pivoted toward the track; a third pivot bearing, which moveably connects the support flap and the guide element to each other; an airbag, fixed on the airbag module, in particular on the support flap and/or on the bracket, folded in the closed state of the airbag module and unfolded in the open state of the airbag module, and which projects past the front end of the support flap in its unfolded state, so that the unfolded airbag and the support flap together form an impact protection for a person on the track; wherein a pivot bearing, selected from the group consisting of the first pivot bearing, the second pivot bearing, and the third pivot bearing, is a displaceable pivot bearing.
Method of producing a metallic strip by continuous rolling, in which firstly a slab is cast in a casting machine and subsequently the slab is continuously rolled in a rolling train with at least one roll stand, wherein the casting machine comprises a strip guide in which the cast slab is guided in conveying direction in the direction of the rolling train, wherein the material of the slab is cooled in the region of the strip guide by spraying on a cooling medium by means of a number of cooling devices and wherein each cooling device comprises a number of spray nozzles which are arranged adjacent to one another in a direction transverse to the conveying direction and by way of which the cooling medium is delivered onto the slab, characterised in that at least one of the cooling devices is operated so that cooling medium is delivered onto the slab only by way of a number of spray nozzles arranged in the centre region of the slab, whereas no cooling medium is delivered onto the slab by way of the spray nozzles disposed in the edge region of the slab, or that cooling medium is delivered onto the slab by way of a number of spray nozzles arranged in the centre region of the slab, whereas cooling medium is delivered only to a reduced extent onto the slab by way of the spray nozzles disposed in the edge region of the slab, wherein in the region of the strip guide and/or in the region between the strip guide and the rolling train only the edge region of the slab is protected by means of a thermal insulation against cooling, and wherein the slab between the casting machine and the rolling train is for equalisation of the temperature between the centre region of the slab and the edge region of the slab guided along an equalisation path with a length (Ls) resulting from: L S ≥ k ⋅ H B 0.5 ⋅ v B wherein L S length of the equalising path in metres H B thickness of the slab in millimetres v B casting speed of the slab in metres/minutes k dimensional coefficient: k = 0.10. L S length of the equalising path in metres H B thickness of the slab in millimetres v B casting speed of the slab in metres/minutes k dimensional coefficient: k = 0.10.
A non-transitory computer-readable medium storing instructions that, when executed by a computing device, cause the computing device to perform a method, the method comprising: hosting at least one service; communicatively coupling with a first end-user device; receiving a request from the first end-user device for the at least one service; controlling a back off period of the first end-user device by determining a retry time that is specific to the request from the first end-user device, wherein the retry time is based on priority access associated with a user of the first end-user device; and relaying the retry time to the first end-user device. hosting at least one service; communicatively coupling with a first end-user device; receiving a request from the first end-user device for the at least one service; controlling a back off period of the first end-user device by determining a retry time that is specific to the request from the first end-user device, wherein the retry time is based on priority access associated with a user of the first end-user device; and relaying the retry time to the first end-user device.
A system comprising: a first computing device; a second computing device; and a first packet forwarding device, wherein each of the first computing device and the second computing device is communicatively coupled to a respective port of the first packet forwarding device, and wherein for a first packet received from the first computing device, the first packet forwarding device is configured to: determine that a destination MAC address of the first packet is associated with the port on which the first packet was received; and forward the first packet to the second computing device, responsive to the determination that the destination MAC address of the first packet is associated with the port on which the first packet was received; and for a second packet received from the second computing device, the first packet forwarding device is configured to forward the second packet via the port associated with a source MAC address of the second packet. a first computing device; a second computing device; and a first packet forwarding device, wherein each of the first computing device and the second computing device is communicatively coupled to a respective port of the first packet forwarding device, and wherein for a first packet received from the first computing device, the first packet forwarding device is configured to: determine that a destination MAC address of the first packet is associated with the port on which the first packet was received; and forward the first packet to the second computing device, responsive to the determination that the destination MAC address of the first packet is associated with the port on which the first packet was received; and determine that a destination MAC address of the first packet is associated with the port on which the first packet was received; and forward the first packet to the second computing device, responsive to the determination that the destination MAC address of the first packet is associated with the port on which the first packet was received; and for a second packet received from the second computing device, the first packet forwarding device is configured to forward the second packet via the port associated with a source MAC address of the second packet.
A film, containing at least one polyvinyl acetal, at least one plasticizer and 0.01-1.5% by weight of at least one UV absorber selected from the compounds of formulas,, or where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, = H, halogen atom, alkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl moiety with 1 to 20 carbon atoms, each unsubstituted or substituted by aldehyde, keto or epoxy groups, with the provision that at least one of the moieties R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14 has a carboxy, sulfoxy or phosphate group with an alkali, alkaline earth or ammonium ion as the counterion.
A method for preparing a beverage, characterised in that it comprises: a first step during which, by means of a capsule that is inserted into a percolation chamber of a percolation element and such a capsule is of the type presenting different infusion chambers (26 and 27), each containing a corresponding infuse, a water flow coming from a tank is caused to reach a predetermined temperature; and a second step wherein, at a predetermined temperature reached by the water in a heat exchanger, a pump is controlled; said pump channeling the water along a duct and along two channels, the first channel being defined by a first duct, by a first water flow inlet hole into said percolation chamber of said percolation element, by a first infusion chamber of the capsule, and by a first water flow outlet hole from said percolation chamber of said percolation element; and the second channel being defined by a second duct, by a second water flow inlet hole into said percolation chamber of said percolation element, by a second infusion chamber of the capsule, and by a second water flow outlet hole from said percolation chamber of said percolation element. a first step during which, by means of a capsule that is inserted into a percolation chamber of a percolation element and such a capsule is of the type presenting different infusion chambers (26 and 27), each containing a corresponding infuse, a water flow coming from a tank is caused to reach a predetermined temperature; and a second step wherein, at a predetermined temperature reached by the water in a heat exchanger, a pump is controlled; said pump channeling the water along a duct and along two channels, the first channel being defined by a first duct, by a first water flow inlet hole into said percolation chamber of said percolation element, by a first infusion chamber of the capsule, and by a first water flow outlet hole from said percolation chamber of said percolation element; and the second channel being defined by a second duct, by a second water flow inlet hole into said percolation chamber of said percolation element, by a second infusion chamber of the capsule, and by a second water flow outlet hole from said percolation chamber of said percolation element.
A porous membrane comprising cellulose fibers, wherein said cellulose fibers comprise a mixture of: more than 50% by weight and 99 % by weight or less of first raw material cellulose fibers having a surface area determined by congo red coloring of 250 m 2 /g or more and 500 m 2 /g or less; and 1 % by weight or more and less than 50% by weight of second raw material cellulose fibers having a surface area determined by congo red coloring of 150 m 2 /g or more and less than 250 m 2 /g, and a hydrophilic polymer binder in an amount ranging from 3 to 80 parts by weight with respect to 100 parts by weight of said mixture. more than 50% by weight and 99 % by weight or less of first raw material cellulose fibers having a surface area determined by congo red coloring of 250 m 2 /g or more and 500 m 2 /g or less; and 1 % by weight or more and less than 50% by weight of second raw material cellulose fibers having a surface area determined by congo red coloring of 150 m 2 /g or more and less than 250 m 2 /g, and a hydrophilic polymer binder in an amount ranging from 3 to 80 parts by weight with respect to 100 parts by weight of said mixture.
Method for coupling a hydroelectric power plant in a turbine mode to a grid, in order to generate power for said grid, said hydroelectric power plant comprising at least a first hydroelectric unit and a second hydroelectric unit, each provided with a runner mechanically coupled to a shaft line and to a generator, a distributor comprising guide vanes to control a flow of water to said runner, said hydroelectric power plant further comprising a variable frequency drive, the method comprising: a) starting the rotation of at least said first hydroelectric unit and said second hydroelectric unit; b) connecting the variable frequency drive to the generator of the first hydroelectric unit and to the grid and stabilizing the speed of the first hydroelectric unit; c) connecting the first hydroelectric unit to the grid and disconnecting the generator of the first hydroelectric unit from the variable frequency drive; d) connecting said variable frequency drive to the generator of the second hydroelectric unit and to the grid and stabilizing the speed of the second hydroelectric unit; e) connecting the second hydroelectric unit to the grid and disconnecting the generator of the second hydroelectric unit from said variable frequency drive. a) starting the rotation of at least said first hydroelectric unit and said second hydroelectric unit; b) connecting the variable frequency drive to the generator of the first hydroelectric unit and to the grid and stabilizing the speed of the first hydroelectric unit; c) connecting the first hydroelectric unit to the grid and disconnecting the generator of the first hydroelectric unit from the variable frequency drive; d) connecting said variable frequency drive to the generator of the second hydroelectric unit and to the grid and stabilizing the speed of the second hydroelectric unit; e) connecting the second hydroelectric unit to the grid and disconnecting the generator of the second hydroelectric unit from said variable frequency drive.
A method for manufacturing a floor covering characterised in that it comprises the steps of: (a) vulcanising a layer, called support layer, made of elastomer, (b) assembling a layer, called intermediate layer, to the support layer during the step of vulcanising, the intermediate layer being made of a material selected from the group consisting of polyester, polyetheretherketone, polyetherimide, polysulfone, polyimide, polyamide, fluoropolymer, polyurethane and paper, (c) printing a layer, called print layer, on the intermediate layer or on a layer, called protective layer, which is transparent, in the case where the print layer has been printed on the intermediate layer, assembling the transparent protective layer to the print layer of the set comprising the print layer, the intermediate layer and the support layer, or in the case where the print layer has been printed on the transparent protective layer, assembling the print layer of the set comprising the print layer and the protective layer to the intermediate layer of the set comprising the intermediate layer and the support layer. (a) vulcanising a layer, called support layer, made of elastomer, (b) assembling a layer, called intermediate layer, to the support layer during the step of vulcanising, the intermediate layer being made of a material selected from the group consisting of polyester, polyetheretherketone, polyetherimide, polysulfone, polyimide, polyamide, fluoropolymer, polyurethane and paper, (c) printing a layer, called print layer, on the intermediate layer or on a layer, called protective layer, which is transparent, in the case where the print layer has been printed on the intermediate layer, assembling the transparent protective layer to the print layer of the set comprising the print layer, the intermediate layer and the support layer, or in the case where the print layer has been printed on the transparent protective layer, assembling the print layer of the set comprising the print layer and the protective layer to the intermediate layer of the set comprising the intermediate layer and the support layer.
A compound selected from the group consisting of: 4-( -1-{[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}ethyl)benzoic acid; and 4-[ -1-({[5-chloro-2-(3-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid, or a pharmaceutically acceptable salt thereof for the use in the reduction of tumor size of cancer in a human or an animal, wherein the cancer is at least one kind selected from the group consisting of gastroenterological cancer, prostate cancer, lung cancer, and breast cancer. 4-( -1-{[5-chloro-2-(4-fluorophenoxy)benzoyl]amino}ethyl)benzoic acid; and 4-[ -1-({[5-chloro-2-(3-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid, or a pharmaceutically acceptable salt thereof for the use in the reduction of tumor size of cancer in a human or an animal, wherein the cancer is at least one kind selected from the group consisting of gastroenterological cancer, prostate cancer, lung cancer, and breast cancer.
Surgical drill bit able to be connected to a surgical tool, wherein said drill bit comprises a flexible stem completely made of polymeric material and provided with a proximal part to which a pointed end is directly coupled and with a distal part which has an attachment for the rotational connection to said tool wherein said flexible stem develops along a central axis of development and comprises, in a single body, a flexible central part, disposed between said distal part and said proximal part, wherein said distal part comprises an attachment end which has said attachment and said proximal part has a connection end to which said pointed end is coupled, wherein said flexible central part has a three-dimensional reticular structure with meshes of polymeric material consisting of a repetition in space of meshes formed by bilobed elements, each bilobed element being connected to at least one contiguous bilobed element by at least two nodes, characterized in that said at least two nodes which connect one bilobed element to at least one contiguous bilobed element are disposed substantially angularly opposite each other with respect to said central axis of development.
A heterodimer comprising a first polypeptide sequence and a second polypeptide sequence, wherein the first polypeptide sequence comprises a first nuclease domain, a second nuclease domain and a first Fc domain, and wherein the second polypeptide sequence consists of a second Fc domain, wherein the first nuclease domain is DNasel and the second nuclease domain is RNasel, and wherein the first and second Fc domains comprise one or more CH3 mutations to preferentially form heterodimers, and wherein the DNase1 is operably linked with or without a linker to the N-terminus of the first Fc domain, and the RNasel is operably linked with or without a linker to the C-terminus of the first Fc domain.