A system comprising a ventilator and a patient monitor device, wherein the patient monitor device is a separate and discrete device from the ventilator, the ventilator comprising: a pressure generator configured to generate a pressurized flow of breathable gas; a subject interface configured to interface between the pressure generator and a breathing circuit to deliver the pressurized flow of breathable gas to the airway of a subject through the subject interface; a communications transceiver configured to receive communication signals from the patient monitor device, the communication signals comprising information related to physiological parameters of the subject; a plurality of ventilation sensors configured to generate one or more output signals conveying measurements related to respiratory parameters of the subject; one or more processors configured to execute processing modules, the processing modules comprising: a control module configured to control the pressure generator such that one or more gas parameters of the pressurized flow of breathable gas are varied over time in accordance with a respiratory therapy regimen; and a regimen adjustment module configured to determine adjustments to the respiratory therapy regimen based on the communication signals received from the patient monitor device such that the physiological parameters indicated in the communication signals are used for closed-loop control to adjust the respiratory therapy regimen, characterized in that the patient monitor device includes one or more patient monitor sensors; wherein the patient monitor sensors are configured to generate output signals conveying information related to the physiological parameters of the subject; the processing modules further comprising a parameter determination module configured to determine one or more parameters from the output signals generated by the plurality of ventilation sensors and one or more patient monitor sensors, wherein executing of the processing modules is based on the simultaneous use of output signals generated by the ventilation sensors and the patient monitor sensors. a pressure generator configured to generate a pressurized flow of breathable gas; a subject interface configured to interface between the pressure generator and a breathing circuit to deliver the pressurized flow of breathable gas to the airway of a subject through the subject interface; a communications transceiver configured to receive communication signals from the patient monitor device, the communication signals comprising information related to physiological parameters of the subject; a plurality of ventilation sensors configured to generate one or more output signals conveying measurements related to respiratory parameters of the subject; one or more processors configured to execute processing modules, the processing modules comprising: a control module configured to control the pressure generator such that one or more gas parameters of the pressurized flow of breathable gas are varied over time in accordance with a respiratory therapy regimen; and a regimen adjustment module configured to determine adjustments to the respiratory therapy regimen based on the communication signals received from the patient monitor device such that the physiological parameters indicated in the communication signals are used for closed-loop control to adjust the respiratory therapy regimen, a control module configured to control the pressure generator such that one or more gas parameters of the pressurized flow of breathable gas are varied over time in accordance with a respiratory therapy regimen; and a regimen adjustment module configured to determine adjustments to the respiratory therapy regimen based on the communication signals received from the patient monitor device such that the physiological parameters indicated in the communication signals are used for closed-loop control to adjust the respiratory therapy regimen, characterized in that the patient monitor device includes one or more patient monitor sensors; wherein the patient monitor sensors are configured to generate output signals conveying information related to the physiological parameters of the subject; the processing modules further comprising a parameter determination module configured to determine one or more parameters from the output signals generated by the plurality of ventilation sensors and one or more patient monitor sensors, wherein executing of the processing modules is based on the simultaneous use of output signals generated by the ventilation sensors and the patient monitor sensors.