mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing -1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one I, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, comprising: (a) reacting a salt of -2-hydroxy-1-(piperazin-1-yl)propan-1-one 6 and 2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde IV with a reducing agent to give -1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one II and (b) reacting II, a palladium catalyst, and 2-aminopyrimidin-5-ylboronic acid III having the structure: to give I. (a) reacting a salt of -2-hydroxy-1-(piperazin-1-yl)propan-1-one 6 and 2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde IV with a reducing agent to give -1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one II and (b) reacting II, a palladium catalyst, and 2-aminopyrimidin-5-ylboronic acid III having the structure:
Radial press designed as a compression ring or hollow piston press with a housing forming a basic structure, a compression ring or hollow piston that can be displaced, in said housing, parallel to a press axis, a multiplicity of press jaws disposed around the press axis and a drive unit, which acts on the multiplicity of press jaws and is braced on the basic structure, by means of which the press jaws can be moved radially toward and away from the press axis, characterized by the following features: radially outside the press jaws at least one fiber structure is provided that surrounds them by extending in annularly closed form around the press axis in a plane oriented substantially perpendicular to the press axis; the fiber structure is part of the drive unit, the displaceable compression ring or hollow piston containing the fiber structure. radially outside the press jaws at least one fiber structure is provided that surrounds them by extending in annularly closed form around the press axis in a plane oriented substantially perpendicular to the press axis; the fiber structure is part of the drive unit, the displaceable compression ring or hollow piston containing the fiber structure.
System for controlling the coupling / decoupling of a vehicle drive device, said system comprising said drive device, actuation means, at least one vehicle movement means and one control means, the control device. drive being actuated by the actuating means, wherein the vehicle moving means is driven by the drive device when in coupling mode, the actuating means exhibiting a maximum allowable speed of operation as well as an operating threshold upward speed (Sh), lower than said maximum speed, controlling, via the control means, the decoupling of the drive device, characterized in that, once the decoupling command has been sent, the control means control atminus a value of the speed gradient of the displacement means to confirm or invalidate the decoupling command.
Process for the anaerobic purification of waste water using a sludge bed system, which process comprises feeding waste water and recycle water to the lower part of an upflow reactor containing mainly granular biomass thus producing biogas in the treatment passing the resulting gas/liquid/solid mixture upward and separating the gas and solid from the liquid in a three phase separator and thereby generating an anaerobic effluent that is withdrawn from the top of the separator, characterized by withdrawing the recycle water separately from the effluent, wherein the recycle water is withdrawn after the separation of the gas from the liquid either from the bottom part of the three phase separator or from the top of the reactor outside the three phase separator.
A touch input device which comprises a touch screen, the touch input device being capable of detecting touch pressure, the touch input device being configured to perform mutually different operations with respect to a first touch which occurs on the touch screen and is maintained during a time period equal to or greater than a first time period, wherein the first touch is maintained at a pressure less than a first pressure within the first time period, and a second touch which occurs on the touch screen and comprises a time interval having a pressure greater than the first pressure within the first time period, and which is configured to perform an operation different from the operations corresponding to the first touch and the second touch, with respect to a third touch which occurs on the touch screen and is maintained during a time period less than the first time period, wherein the third touch is maintained at a pressure less than the first pressure during the time-period where the third touch is maintained.
A clock recovery circuit, comprising: a receiver circuit adapted to decode a differentially encoded signal input on a plurality of data lines, where at least one data symbol is differentially encoded in state transitions of the differentially encoded signal; and a clock extraction circuit adapted to obtain a clock signal from state transition signals derived from the state transitions, wherein: the clock extraction circuit includes a feedback delayed instance of a first state transition signal that is used to obtain the clock signal; and the clock extraction circuit is adapted to use the feedback delayed instance of the first state transition signal to compensate for skew in the different data lines and mask data state transition glitches. a receiver circuit adapted to decode a differentially encoded signal input on a plurality of data lines, where at least one data symbol is differentially encoded in state transitions of the differentially encoded signal; and a clock extraction circuit adapted to obtain a clock signal from state transition signals derived from the state transitions, wherein: the clock extraction circuit includes a feedback delayed instance of a first state transition signal that is used to obtain the clock signal; and the clock extraction circuit is adapted to use the feedback delayed instance of the first state transition signal to compensate for skew in the different data lines and mask data state transition glitches. the clock extraction circuit includes a feedback delayed instance of a first state transition signal that is used to obtain the clock signal; and the clock extraction circuit is adapted to use the feedback delayed instance of the first state transition signal to compensate for skew in the different data lines and mask data state transition glitches.
Numerical control for operating a machine tool comprising a number of axles, with a drive controller for each axle to be controlled, wherein the drive controllers can be parameterized by machine parameters (Kp, Ki, Kd, MP, Tt) and in this way are adaptable for a wide variety of machine tools, characterized in that controlled variables (wnom, wact, Iqnom, Iqact, Unom, vnom, anom, I_int) and machine parameters (Kp, Ki, Kd, MP, Tt) can be selected at tapping points in the drive controllers and can be branched off from the drive controller in order to be used as arguments or parameters of a user-defined function for the calculation of an output value, wherein the output value serves for the function-dependent influencing of one of the drive controllers, by the output value being returned additively, multiplicatively or by a mathematical convolution to an injection point in one of the drive controllers.
A method of characterising two or more target polynucleotides, comprising: (a) contacting a first target polynucleotide with a transmembrane pore in a membrane such that the first target polynucleotide moves through the pore, wherein the interaction of a first polynucleotide with the pore facilitates the attachment of the first target polynucleotide to a subsequent target polynucleotide; (b) sequentially attaching to the first target polynucleotide one or more subsequent target polynucleotides to provide a concatenated polynucleotide within which the target polynucleotides move through the pore in attachment order, wherein a subsequent target polynucleotide is selectively attached to the preceding target polynucleotide in the attachment order when the preceding target polynucleotide moves through the pore; and (c) taking one or more measurements which are indicative of one or more characteristics of the concatenated polynucleotide as it moves with respect to the pore. (a) contacting a first target polynucleotide with a transmembrane pore in a membrane such that the first target polynucleotide moves through the pore, wherein the interaction of a first polynucleotide with the pore facilitates the attachment of the first target polynucleotide to a subsequent target polynucleotide; (b) sequentially attaching to the first target polynucleotide one or more subsequent target polynucleotides to provide a concatenated polynucleotide within which the target polynucleotides move through the pore in attachment order, wherein a subsequent target polynucleotide is selectively attached to the preceding target polynucleotide in the attachment order when the preceding target polynucleotide moves through the pore; and (c) taking one or more measurements which are indicative of one or more characteristics of the concatenated polynucleotide as it moves with respect to the pore.
A commingled yarn comprising a continuous thermoplastic resin fiber, a continuous reinforcing fiber, and a surface treatment agent for the continuous reinforcing fiber and/or sizing agent for the continuous reinforcing fiber; wherein the commingled yarn comprises the surface treatment agent and/or sizing agent in a content of 2.0% by weight or more, relative to a total amount of the continuous thermoplastic resin fiber and the continuous reinforcing fiber, and has a dispersibility of the continuous thermoplastic resin fiber and the continuous reinforcing fiber of 70% or larger; wherein the dispersibility is calculated using the equation below: D % = 1 − Lcf + Lpoly / Ltot ∗ 100 (in the formula, D represents the dispersibility, and Lcf, Lpoly and Ltot are determined according to the specification).
Crosshead for use as an upper and/or lower beam (50, 60) in a press, particularly a free-form forging press or a drop forging press, comprising a top chord and a bottom chord connected with the top chord by way of a first and a second side post (3, 4), wherein the first side post is arranged in the region of a first distal end and the second side post in the region of a second distal end of the crosshead, wherein the crosshead (1, 50) has between the two side posts (3, 4) a framework support structure by way of which the top chord and bottom chord are additionally connected together, characterised in that the top chord and the bottom chord each have a centrally arranged opening (9, 10), which openings are in alignment with one another and define a centre region of the crosshead and are provided for connection with a main cylinder of the press, wherein the top chord and the bottom chord each have on either side of the central opening (9, 10) a further opening (12, 13, 14, 15), which openings are in alignment with one another, for connection with a first and a second press cylinder (111, 112) of the press, wherein the framework support structure comprises a plurality of transversely extending bracing ribs (20, 21, 22, 23) which extend from the centre region of the bottom chord in the direction of the ends of the top chord (24, 25) and are fixedly connected with the side posts (3, 4), and wherein each two bracing ribs (20, 21, 22, 23) arranged parallel to one another are connected together by way of an area element (26, 27) and each of the area elements (26, 27) has an opening (28, 29) disposed in alignment with the press cylinder openings (12, 13, 14, 15). the top chord and the bottom chord each have a centrally arranged opening (9, 10), which openings are in alignment with one another and define a centre region of the crosshead and are provided for connection with a main cylinder of the press, wherein the top chord and the bottom chord each have on either side of the central opening (9, 10) a further opening (12, 13, 14, 15), which openings are in alignment with one another, for connection with a first and a second press cylinder (111, 112) of the press, wherein the framework support structure comprises a plurality of transversely extending bracing ribs (20, 21, 22, 23) which extend from the centre region of the bottom chord in the direction of the ends of the top chord (24, 25) and are fixedly connected with the side posts (3, 4), and wherein each two bracing ribs (20, 21, 22, 23) arranged parallel to one another are connected together by way of an area element (26, 27) and each of the area elements (26, 27) has an opening (28, 29) disposed in alignment with the press cylinder openings (12, 13, 14, 15).
A torque-restoring element for an oscillator for a mechanical timepiece and having an oscillator frequency, said torque restoring element comprising: a spiral spring body (110a, 110b) having a number N turnings with an inner terminal end for engagement with a rotational inertial element via a collet, and an outer terminal end for engagement with a stationary cock element, and having a width (140a, 140b), a height (150a, 150b) and a total arc length; wherein the spiral spring body (110a, 110b) includes a core (180a, 180b) formed from mono-crystalline silicon wafer oriented along the crystallographic axis <110>; and wherein the spiral spring body (110a, 110b) includes at least one peripheral coating of a material having a thermal elastic constant different from that of the core (180a, 180b) of the spiral spring body (110a, 110b) so as to maintain the oscillator frequency of an oscillator including the torque-restoring element substantially insensitive to variations of ambient temperature. a spiral spring body (110a, 110b) having a number N turnings with an inner terminal end for engagement with a rotational inertial element via a collet, and an outer terminal end for engagement with a stationary cock element, and having a width (140a, 140b), a height (150a, 150b) and a total arc length; wherein the spiral spring body (110a, 110b) includes a core (180a, 180b) formed from mono-crystalline silicon wafer oriented along the crystallographic axis <110>; and wherein the spiral spring body (110a, 110b) includes at least one peripheral coating of a material having a thermal elastic constant different from that of the core (180a, 180b) of the spiral spring body (110a, 110b) so as to maintain the oscillator frequency of an oscillator including the torque-restoring element substantially insensitive to variations of ambient temperature.
A method of forming a magnetic electrode of a magnetic tunnel junction, comprising: forming non-magnetic MgO-comprising material over conductive material of the magnetic electrode being formed; forming amorphous metal over the non-magnetic MgO-comprising material, the amorphous metal comprising an alloy of at least one of Mo and Cr, and at least one of Fe, Co, and Ni; forming amorphous magnetic electrode material comprising Co and Fe over the amorphous metal, the amorphous magnetic electrode material having from 0.0 atomic percent to no more than 0.1 atomic percent B; forming non-magnetic tunnel insulator material comprising MgO directly against the amorphous magnetic electrode material, the tunnel insulator material having from 0.0 atomic percent to no more than 0.1 atomic percent B; and after forming the non-magnetic tunnel insulator material, annealing the amorphous Co and Fe-comprising magnetic electrode material at a temperature of at least 250°C to form crystalline Co and Fe-comprising magnetic electrode material from an MgO-comprising surface of the non-magnetic tunnel insulator material, the crystalline Co and Fe-comprising magnetic electrode material having from 0.0 atomic percent to no more than 0.1 atomic percent B. forming non-magnetic MgO-comprising material over conductive material of the magnetic electrode being formed; forming amorphous metal over the non-magnetic MgO-comprising material, the amorphous metal comprising an alloy of at least one of Mo and Cr, and at least one of Fe, Co, and Ni; forming amorphous magnetic electrode material comprising Co and Fe over the amorphous metal, the amorphous magnetic electrode material having from 0.0 atomic percent to no more than 0.1 atomic percent B; forming non-magnetic tunnel insulator material comprising MgO directly against the amorphous magnetic electrode material, the tunnel insulator material having from 0.0 atomic percent to no more than 0.1 atomic percent B; and after forming the non-magnetic tunnel insulator material, annealing the amorphous Co and Fe-comprising magnetic electrode material at a temperature of at least 250°C to form crystalline Co and Fe-comprising magnetic electrode material from an MgO-comprising surface of the non-magnetic tunnel insulator material, the crystalline Co and Fe-comprising magnetic electrode material having from 0.0 atomic percent to no more than 0.1 atomic percent B.
Vehicle seat comprising a seat cushion part and a backrest cushion part, the seat cushion part and/or the backrest cushion part being delimited on the left-hand and right-hand side by respective side cheeks (4, 5, 6, 7) for supporting a vehicle seat user, the respective side cheeks (4, 5, 6, 7) comprising at least one cushion (28, 29) which can change shape in the width direction of the seat, and at least one cushion portion (30, 31) in which the at least one cushion (28, 29) is embedded, characterised in that, a fibrous tissue (32, 33) is embedded in a planar manner in foam in the at least one cushion portion (30, 31) made of foam material, in order to stabilise said cushion portion, which fibrous tissue encompasses at least one embedded cushion (28, 29), the fibres of the fibrous tissue (32, 33) being oriented, at least in one part of the surface spanned by the fibrous tissue, at a non-zero angle to the plane spanning the width direction of the seat and an elevation direction (25, 27) of the side cheek.
A blower assembly comprising: a centrifugal fan rotatable about a fan axis, the centrifugal fan having a plurality of axially extending impeller blades, a first axial end, and an air inlet, the air inlet being at the first axial end of the centrifugal fan, the impeller blades having inner surfaces that combine to define a fan inner diameter d f; a motor assembly comprising a stator, a rotor, and an air directing surface, the motor assembly entirely contained within the centrifugal fan, the rotor being configured to rotate relative to the stator about a rotor axis, the centrifugal fan being coupled to the rotor in a manner such that the centrifugal fan rotates with the rotor about the rotor axis, the air directing surface being shaped and configured to direct air drawn into the air inlet radially outwardly toward the impeller blades, the air directing surface being stationary relative to the stator and having a first end and a second end, a portion of the rotor and the stator being located between the first end and the second end of the air directing surface and surrounded by the air directing surface, the air directing surface extending generally along the rotor axis from the first end to the second end, at least a surface region of the air directing surface generally circumscribing the rotor axis and diverging radially outwardly as such surface region of the air directing surface extends away from the first end of the air directing surface and toward the second end of the air directing surface, the air directing surface having a nose region, the nose region extending axially from the first end of the air directing surface toward the second end of the air directing surface, the nose region having a cross section in a cross-sectional plane that includes the rotor axis, said surface region of the air directing surface being axially aligned with portions of the impeller blades such that said surface region of the air directing surface is surrounded by said portions of the impeller blades. a centrifugal fan rotatable about a fan axis, the centrifugal fan having a plurality of axially extending impeller blades, a first axial end, and an air inlet, the air inlet being at the first axial end of the centrifugal fan, the impeller blades having inner surfaces that combine to define a fan inner diameter d f; a motor assembly comprising a stator, a rotor, and an air directing surface, the motor assembly entirely contained within the centrifugal fan, the rotor being configured to rotate relative to the stator about a rotor axis, the centrifugal fan being coupled to the rotor in a manner such that the centrifugal fan rotates with the rotor about the rotor axis, the air directing surface being shaped and configured to direct air drawn into the air inlet radially outwardly toward the impeller blades, the air directing surface being stationary relative to the stator and having a first end and a second end,
An anti-cancer camptothecin analog selected from the group consisting of: 4-Ethyl-4-hydroxy-9-methoxy-11-(2-trimethylsitanyl-ethyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 7-(2'-Trimethylsilanyl) ethyl-10-(methoxymethyl) oxy camptothecin; 7-(2'-Trimethylsilanyl)ethyl-10-(3'-hydroxypropyl)oxy camptothecin; 7-(2'-Trimethylsilanyl)ethyl-10-(2'-methoxyethoxy) camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-isopropoxy camptothecin; 5-Hydroxy-7-(2'-trimethylsilanyl) ethyl-10-ethoxy camptothecin; 5-Hydroxy-7-(2'-trimethylsilanyl) ethyl-10-amidomethoxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-dimethylcarbamic acid camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-(ethoxycarbonylmethyl)oxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-(amidomethyl)oxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-(carboxymethyl)oxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-(4-morpholinecarbonyl) oxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-(dimethylthiocarbamoyl)oxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-ethoxy camptothecin; 7-(2'-Trimethylsilanyl) ethyl-10-cyanomethoxy camptothecin; 10-(Trimethylsilanylmethyl) oxy camptothecin, and pharmaceutically-acceptable salts thereof.
A computer-implemented method for forensically analysing and determining a financial network associated with a network security threat, wherein the network security threat is the unauthorised modification of routing information within the financial network, the method comprising: a) obtaining details of a flagged network event comprising data associated with the network security threat, the network event being between a first dataset and a destination dataset; b) tracing the data associated with the network security threat from the first dataset to a further dataset, the tracing involving obtaining details of at least one past network event between the first dataset and the further dataset; c) comparing details of the further dataset to predefined criteria to identify whether the further dataset is an intermediate dataset or a source dataset from which the data originated and adding the details of the further dataset to a forensic report; d) outputting the forensic report. a) obtaining details of a flagged network event comprising data associated with the network security threat, the network event being between a first dataset and a destination dataset; b) tracing the data associated with the network security threat from the first dataset to a further dataset, the tracing involving obtaining details of at least one past network event between the first dataset and the further dataset; c) comparing details of the further dataset to predefined criteria to identify whether the further dataset is an intermediate dataset or a source dataset from which the data originated and adding the details of the further dataset to a forensic report; d) outputting the forensic report.