A compound having the formula wherein n is 0; m is 0 to 3; R 1 and R 4 are the same or different and are independently selected from the group consisting of hydrogen, C 1 -C 12 aliphatic; wherein R 1 and R 4 can independently be unsubstituted or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 ether, a C 1 -C 6 thioether, a C 1 -C 6 ester, a C 1 -C 6 ketone, a C 1 -C 6 ketimine, a C 1 -C 6 sulfone, a C 1 -C 6 sulfoxide, a C 1 -C 6 primary amide, a C 1 -C 6 secondary amide, a halo C 1 -C 6 alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, -C O-C 1 -C 6 alkyl, -OC O-C 1 -C 6 alkyl, -OC NR'R', -N(R')C NR'R', -N(R')C O-C 1 -C 6 alkyl, oxo; wherein each R' is independently selected, from the group consisting of hydrogen and C 1 -C 6 alkyl; R 2 is independently selected from the group consisting of hydrogen, an amino group, a halogen, a cyano group, a nitro group, a nitroso group, C 1 -C 12 aliphatic; wherein, independently any R 2 can be unsubstituted, or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 ether, a C 1 -C 6 thioether, a C 1 -C 6 ester, a C 1 -C 6 ketone, a C 1 -C 6 ketimine, a C 1 -C 6 sulfone, a C 1 -C 6 sulfoxide, a C 1 -C 6 primary amide, a C 1 -C 6 secondary amide, a halo C 1 -C 6 alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, -C O-C 1 -C 6 alkyl, -OC O-C 1 -C 6 alkyl, -OC NR'R', -N(R')C NR'R', -N(R')C O-C 1 -C 6 alkyl, oxo; wherein R' is independently selected, for each occurrence, from the group consisting of hydrogen and C 1 -C 6 alkyl; wherein R 1 and R 4 are not simultaneously hydrogen; or a pharmaceutically acceptable salt or a hydrate thereof. wherein n is 0; m is 0 to 3; R 1 and R 4 are the same or different and are independently selected from the group consisting of hydrogen, C 1 -C 12 aliphatic; wherein R 1 and R 4 can independently be unsubstituted or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 ether, a C 1 -C 6 thioether, a C 1 -C 6 ester, a C 1 -C 6 ketone, a C 1 -C 6 ketimine, a C 1 -C 6 sulfone, a C 1 -C 6 sulfoxide, a C 1 -C 6 primary amide, a C 1 -C 6 secondary amide, a halo C 1 -C 6 alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, -C O-C 1 -C 6 alkyl, -OC O-C 1 -C 6 alkyl, -OC NR'R', -N(R')C NR'R', -N(R')C O-C 1 -C 6 alkyl, oxo; wherein each R' is independently selected, from the group consisting of hydrogen and C 1 -C 6 alkyl; R 2 is independently selected from the group consisting of hydrogen, an amino group, a halogen, a cyano group, a nitro group, a nitroso group, C 1 -C 12 aliphatic; wherein, independently any R 2 can be unsubstituted, or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 ether, a C 1 -C 6 thioether, a C 1 -C 6 ester, a C 1 -C 6 ketone, a C 1 -C 6 ketimine, a C 1 -C 6 sulfone, a C 1 -C 6 sulfoxide, a C 1 -C 6 primary amide, a C 1 -C 6 secondary amide, a halo C 1 -C 6 alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, -C O-C 1 -C 6 alkyl, -OC O-C 1 -C 6 alkyl, -OC NR'R', -N(R')C NR'R', -N(R')C O-C 1 -C 6 alkyl, oxo; wherein R' is independently selected, for each occurrence, from the group consisting of hydrogen and C 1 -C 6 alkyl; wherein R 1 and R 4 are not simultaneously hydrogen;