A sealing and guiding system for a packaging machine comprising a processing zone, for receiving products to be processed, and an activation zone, that are adjacent each other; the system comprises: a separating wall, for separating the processing zone from the activation zone; at least one movement actuating element, that develops from the activation zone to the processing zone, crossing the separating wall and has a longitudinal developing axis; movement actuating means, that are arranged in the activation zone, for moving the movement actuating element at least along a first direction, transverse to the respective axis; wherein, with the system, the movement actuating element is not subjected to axial translations; characterized in that: the separating wall comprises: - a first part comprising at least a first housing delimited by a first circular edge; - at least a first disk, that can be inserted in the first housing so as to be rotatable with respect to the first part; the first disk comprises in turn at least a second housing delimited by a second circular edge, that is eccentric with respect to the center of the first disk; - at least a second disk, that can be inserted in the second housing so as to be rotatable with respect to the first disk; the second disk comprises, in turn, a third housing delimited by a third circular edge, that is eccentric with respect to the center of the second disk; with the movement actuating element that is inserted in the third housing; and in that the system comprises rotary sealing means (200, 210, 220), arranged at the first housing, at the second housing and at the third housing, allowing the sealing between the processing zone and the activation zone and the relative rotation of the first disk, of the second disk and of the movement actuating element. the system comprises: a separating wall, for separating the processing zone from the activation zone; at least one movement actuating element, that develops from the activation zone to the processing zone, crossing the separating wall and has a longitudinal developing axis; movement actuating means, that are arranged in the activation zone, for moving the movement actuating element at least along a first direction, transverse to the respective axis; wherein, with the system, the movement actuating element is not subjected to axial translations; characterized in that: the separating wall comprises: - a first part comprising at least a first housing delimited by a first circular edge; - at least a first disk, that can be inserted in the first housing so as to be rotatable with respect to the first part; the first disk comprises in turn at least a second housing delimited by a second circular edge, that is eccentric with respect to the center of the first disk; - at least a second disk, that can be inserted in the second housing so as to be rotatable with respect to the first disk; the second disk comprises, in turn, a third housing delimited by a third circular edge, that is eccentric with respect to the center of the second disk; with the movement actuating element that is inserted in the third housing; - a first part comprising at least a first housing delimited by a first circular edge; - at least a first disk, that can be inserted in the first housing so as to be rotatable with respect to the first part; the first disk comprises in turn at least a second housing delimited by a second circular edge, that is eccentric with respect to the center of the first disk; - at least a second disk, that can be inserted in the second housing so as to be rotatable with respect to the first disk; the second disk comprises, in turn, a third housing delimited by a third circular edge, that is eccentric with respect to the center of the second disk; with the movement actuating element that is inserted in the third housing; and in that the system comprises rotary sealing means (200, 210, 220), arranged at the first housing, at the second housing and at the third housing, allowing the sealing between the processing zone and the activation zone and the relative rotation of the first disk, of the second disk and of the movement actuating element.