A staple cartridge for use with a stapling device that has an actuator that is selectively actuatable in an axial direction and an anvil that is selectively movable between open and closed positions, said staple cartridge comprising: a cartridge body supportable within the stapling device for selective confronting relationship with an anvil when in a closed position, said cartridge body configured to axially receive the actuator therein; a plurality of staples at least one first staple driver (330a, 330b) movably supported within said cartridge body for contact by the actuator such that, as the actuator is axially advanced through said cartridge body, said at least one first staple driver is driven in a direction toward an anvil when the anvil is in the closed position, said at least one first staple driver defining a first staple support cradle (348, 358) therein supporting a staple of the plurality of staples thereon, said first staple support cradle located a first staple forming distance from a corresponding portion of a closed anvil; and at least one second staple driver (370a, 370b) movably supported within said cartridge body for contact by the actuator such that as the actuator is axially advanced through said cartridge body, said at least one second staple driver is driven in said direction toward a closed anvil, said at least one second staple driver defining a second staple support cradle therein supporting another staple (222") of the plurality of staples thereon, said second staple support cradle located a second staple forming distance from another portion of a closed anvil, wherein said second staple forming distance differs from said first staple forming distance characterised in that the plurality of staples are of the same size and such that the formed height of the staple supported by the first staple support cradle (348, 358) will differ from the formed height of the staple (222") supported by the second staple support cradle. a cartridge body supportable within the stapling device for selective confronting relationship with an anvil when in a closed position, said cartridge body configured to axially receive the actuator therein; a plurality of staples at least one first staple driver (330a, 330b) movably supported within said cartridge body for contact by the actuator such that, as the actuator is axially advanced through said cartridge body, said at least one first staple driver is driven in a direction toward an anvil when the anvil is in the closed position, said at least one first staple driver defining a first staple support cradle (348, 358) therein supporting a staple of the plurality of staples thereon, said first staple support cradle located a first staple forming distance from a corresponding portion of a closed anvil; and at least one second staple driver (370a, 370b) movably supported within said cartridge body for contact by the actuator such that as the actuator is axially advanced through said cartridge body, said at least one second staple driver is driven in said direction toward a closed anvil, said at least one second staple driver defining a second staple support cradle therein supporting another staple (222") of the plurality of staples thereon, said second staple support cradle located a second staple forming distance from another portion of a closed anvil, wherein said second staple forming distance differs from said first staple forming distance characterised in that the plurality of staples are of the same size and such that the formed height of the staple supported by the first staple support cradle (348, 358) will differ from the formed height of the staple (222") supported by the second staple support cradle.