A sole structure for an article of footwear, the sole structure comprising: a midsole having a plurality of projections, at least one of the plurality of projections forming a first portion of a peripheral side wall of the sole structure; and a fluid-filled chamber (204, 204a) having a central portion, a plurality of lobes extending outward from the central portion and between respective projections of the plurality of projections to form a second portion of the peripheral side wall of the sole structure, a plurality of tunnels fluidly coupling respective lobes of the plurality of lobes to the central portion, and a plurality of channels defined by adjacent lobes of the plurality of lobes and adjacent tunnels of the plurality of tunnels, at least one channel of the plurality of channels having a different shape than an adjacent channel of the plurality of channels, and wherein the fluid-filled chamber (204, 204a) includes a wedge portion disposed between a front medial lobe of the plurality of lobes and a front lateral lobe of the plurality of lobes, wherein the wedge portion tapers outward from the central portion in a direction extending toward an anterior end from the central portion, wherein (i) a distal end wall of a rear lateral lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front lateral lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear lateral lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front lateral lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis, or (ii) wherein a distal end wall of a rear medial lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front medial lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear 1 medial lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front medial lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis. a midsole having a plurality of projections, at least one of the plurality of projections forming a first portion of a peripheral side wall of the sole structure; and a fluid-filled chamber (204, 204a) having a central portion, a plurality of lobes extending outward from the central portion and between respective projections of the plurality of projections to form a second portion of the peripheral side wall of the sole structure, a plurality of tunnels fluidly coupling respective lobes of the plurality of lobes to the central portion, and a plurality of channels defined by adjacent lobes of the plurality of lobes and adjacent tunnels of the plurality of tunnels, at least one channel of the plurality of channels having a different shape than an adjacent channel of the plurality of channels, and wherein the fluid-filled chamber (204, 204a) includes a wedge portion disposed between a front medial lobe of the plurality of lobes and a front lateral lobe of the plurality of lobes, wherein the wedge portion tapers outward from the central portion in a direction extending toward an anterior end from the central portion, wherein (i) a distal end wall of a rear lateral lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front lateral lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear lateral lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front lateral lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis, or (ii) wherein a distal end wall of a rear medial lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front medial lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear 1 medial lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front medial lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis. (i) a distal end wall of a rear lateral lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front lateral lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear lateral lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front lateral lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis, or (ii) wherein a distal end wall of a rear medial lobe of the plurality of lobes defines a substantially rhomboidal shape, while a distal end wall of the front medial lobe of the plurality of lobes defines a substantially triangular shape, wherein a portion of the rear 1 medial lobe defines a rear longitudinal axis along a peripheral side surface and a portion of the front medial lobe defines a front longitudinal axis along a peripheral side surface, and wherein the rear longitudinal axis is substantially parallel to the front longitudinal axis.