mhurhangee/ep-ind-claims huggingface dataset:
A method for monitoring minimal residual disease in a patient following treatment with a composition which comprises a humanized antibody or an epitope-binding fragment thereof that specifically binds to β-amyloid protein, wherein said method comprises: a. bringing a sample suspected to contain β-amyloid protein into contact with a humanized antibody or an epitope-binding fragment thereof that specifically binds β-amyloid protein; b. allowing the humanized antibody or fragment thereof to bind to β-amyloid, protein to form an immunological complex; c. detecting the formation of the immunological complex; d. correlating the presence or absence of the immunological complex with the presence or absence of β-amyloid protein in the sample; and e. comparing the amount of said immunological complex to a normal control value, wherein said humanized antibody comprises: a Light Chain Variable Region (LCVR) as shown in SEQ ID NO: 12; or SEQ ID NO: 12 comprising the amino acid Lys or Gln in Kabat position 45; or the amino acid Phe or Tyr in Kabat position 87; or the amino acid Lys or Arg in Kabat position 50; or the amino acid Asn or Ser in Kabat position 53; and a Heavy Chain Variable Region (HCVR) as shown SEQ ID NO: 15, and wherein an increase in the amount of said immunological complex compared to a normal control value indicates that said patient still suffers from a minimal residual disease. a. bringing a sample suspected to contain β-amyloid protein into contact with a humanized antibody or an epitope-binding fragment thereof that specifically binds β-amyloid protein; b. allowing the humanized antibody or fragment thereof to bind to β-amyloid, protein to form an immunological complex; c. detecting the formation of the immunological complex; d. correlating the presence or absence of the immunological complex with the presence or absence of β-amyloid protein in the sample; and e. comparing the amount of said immunological complex to a normal control value, a Light Chain Variable Region (LCVR) as shown in SEQ ID NO: 12; or SEQ ID NO: 12 comprising the amino acid Lys or Gln in Kabat position 45; or the amino acid Phe or Tyr in Kabat position 87; or the amino acid Lys or Arg in Kabat position 50; or the amino acid Asn or Ser in Kabat position 53; and a Heavy Chain Variable Region (HCVR) as shown SEQ ID NO: 15, and wherein an increase in the amount of said immunological complex compared to a normal control value indicates that said patient still suffers from a minimal residual disease.
A device for contactless communication with a terminal, comprising: an antenna for communication with the terminal; an embedded chip configured to communicate with the terminal in accordance with a contactless transmission protocol whereby a message sent by the terminal sets a specified initial waiting time for a response from the embedded chip to maintain a connection with the terminal, the embedded chip being configured to communicate requests to the terminal to extend the waiting time for response; and a module configured to perform processing formed of a plurality of discrete operations; wherein the embedded chip is configured to, for each waiting time extension request sent to the terminal, communicate a first signal to the module indicating the waiting time extension request has been sent to the terminal; and wherein the module is configured to begin processing a subset of one or more discrete operations in response to the first signal; characterised in that the embedded chip is further configured to communicate a second signal to the module in advance of the extended waiting time resulting from that extension request indicating a further waiting time extension request is scheduled for communication to the terminal, and the module is configured to stop processing the subset of discrete operations in response to the second signal. an antenna for communication with the terminal; an embedded chip configured to communicate with the terminal in accordance with a contactless transmission protocol whereby a message sent by the terminal sets a specified initial waiting time for a response from the embedded chip to maintain a connection with the terminal, the embedded chip being configured to communicate requests to the terminal to extend the waiting time for response; and a module configured to perform processing formed of a plurality of discrete operations; wherein the embedded chip is configured to, for each waiting time extension request sent to the terminal, communicate a first signal to the module indicating the waiting time extension request has been sent to the terminal; and wherein the module is configured to begin processing a subset of one or more discrete operations in response to the first signal; characterised in that the embedded chip is further configured to communicate a second signal to the module in advance of the extended waiting time resulting from that extension request indicating a further waiting time extension request is scheduled for communication to the terminal, and the module is configured to stop processing the subset of discrete operations in response to the second signal.
A drive mechanism of a drug delivery device, comprising: - a piston rod to operably engage with a piston of a cartridge containing a medicament - a first functional component (24, 58) and a second functional component (16, 56) whose position or orientation relative to each other is unambiguously correlated to an axial position of the piston rod and wherein the first and the second functional components (24, 58, 16, 56) are selected such, that operation of the drive mechanism comes along with a relative displacement of first and second functional components (24, 58, 16, 56), characterized in that - the first and/or the second functional component (24, 58, 16, 56) comprise at least one engaging portion (40, 42) to inseparably and to adhesively engage the first and the second functional component (24, 58, 16, 56) with each other for rendering the drive mechanism inoperable when a predefined axial position of the piston rod has been reached, that corresponds to a substantially empty cartridge. - a piston rod to operably engage with a piston of a cartridge containing a medicament - a first functional component (24, 58) and a second functional component (16, 56) whose position or orientation relative to each other is unambiguously correlated to an axial position of the piston rod and wherein the first and the second functional components (24, 58, 16, 56) are selected such, that operation of the drive mechanism comes along with a relative displacement of first and second functional components (24, 58, 16, 56), characterized in that - the first and/or the second functional component (24, 58, 16, 56) comprise at least one engaging portion (40, 42) to inseparably and to adhesively engage the first and the second functional component (24, 58, 16, 56) with each other for rendering the drive mechanism inoperable when a predefined axial position of the piston rod has been reached, that corresponds to a substantially empty cartridge.
A polypeptide of up to 50 amino acids that binds specifically to a ChemerinR polypeptide, wherein the nine C-terminal amino acids of said polypeptide are selected from any member of the group consisting of: YFPGQFAFS, LFPGQFAFS, IFPGQFAFS, FLPGQFAFS, YLPGQFAFS,YVPGQFAFS and YFPGQFAFD-CONH2.
A method of making up human skin, the method comprising: · acquiring at a first location and storing a starting image and/or starting relief of skin grain; and · reproducing on skin an image of skin grain for reproduction and/or relief of skin grain for reproduction corresponding to the starting image and/or relief, possibly after performing processing, the image and/or relief for reproduction being reproduced at a second location that is different from the first location. · acquiring at a first location and storing a starting image and/or starting relief of skin grain; and · reproducing on skin an image of skin grain for reproduction and/or relief of skin grain for reproduction corresponding to the starting image and/or relief, possibly after performing processing, the image and/or relief for reproduction being reproduced at a second location that is different from the first location.
A method of communicating comprising: in response to a request from local device, toggling a transmitter On and Off in a pattern that represents a unit of information, said transmitter configured to transmit high speed data via a communication medium at a first end thereof, the communication medium also having a second end; said transmitter interrupting said communication medium at said first end corresponding to said pattern, each interrupting of said communication medium at said first end resulting in a detection of a loss of signal at said second end; using a detection of a respective loss of signal at said second end for detecting the pattern of interruption of said communication medium at said second end so as to determine said unit of information; and in response to said detection, changing to which remote device of a plurality of remote devices (30, 52) said local device is in communication via said communication medium. in response to a request from local device, toggling a transmitter On and Off in a pattern that represents a unit of information, said transmitter configured to transmit high speed data via a communication medium at a first end thereof, the communication medium also having a second end; said transmitter interrupting said communication medium at said first end corresponding to said pattern, each interrupting of said communication medium at said first end resulting in a detection of a loss of signal at said second end; using a detection of a respective loss of signal at said second end for detecting the pattern of interruption of said communication medium at said second end so as to determine said unit of information; and in response to said detection, changing to which remote device of a plurality of remote devices (30, 52) said local device is in communication via said communication medium.
Method for estimating the load acting on a tire, said method comprising: - obtaining data representative of the deformation undergone by the tire on a rolling surface; - processing the obtained data in order to obtain a first quantity β representative of the deformation extent within a first deformation region substantially corresponding to the footprint between the tire and the rolling surface, characterized in further comprising: processing the obtained data in order to obtain a second quantity σ, different from the first quantity β, representative of the deformation extent in a second deformation region, said second region comprising the first deformation region and having a circumferential extension greater than the circumferential extension of the first deformation region, the second quantity σ being obtained starting from at least a part of the obtained data, which corresponds to a portion of said second deformation region which is external to the footprint; - estimating the load on the basis of both the first quantity β and the second quantity σ thus obtained. - obtaining data representative of the deformation undergone by the tire on a rolling surface; - processing the obtained data in order to obtain a first quantity β representative of the deformation extent within a first deformation region substantially corresponding to the footprint between the tire and the rolling surface, characterized in further comprising: processing the obtained data in order to obtain a second quantity σ, different from the first quantity β, representative of the deformation extent in a second deformation region, said second region comprising the first deformation region and having a circumferential extension greater than the circumferential extension of the first deformation region, the second quantity σ being obtained starting from at least a part of the obtained data, which corresponds to a portion of said second deformation region which is external to the footprint; processing the obtained data in order to obtain a second quantity σ, different from the first quantity β, representative of the deformation extent in a second deformation region, said second region comprising the first deformation region and having a circumferential extension greater than the circumferential extension of the first deformation region, the second quantity σ being obtained starting from at least a part of the obtained data, which corresponds to a portion of said second deformation region which is external to the footprint; - estimating the load on the basis of both the first quantity β and the second quantity σ thus obtained.
A suspended ceiling system comprising metal grid members (10, 30, 45, 62, 70, 80, 85, 108, 125) and rectangular composite acoustical panels (11, 21, 32, 52, 74, 101, 109, 120), the panels (11, 21, 32, 52, 74, 101, 109, 120) having edges (16, 22, 33, 56, 78, 112) at their peripheries, the grid members (10, 30, 45, 62, 70, 80, 85, 108, 125) having a cross section generally like an inverted T such that they provide oppositely extending flanges (13, 31, 47, 63, 71, 81, 91) adapted to support the panels (11, 21, 32, 52, 74, 101, 109, 120) at their edges (16, 22, 33, 56, 78, 112), a resilient element (47, 66, 76, 94, 86, 95, 106, 113, 114, 117, 122) at a juncture between a support on the grid member flanges (13, 31, 47, 63, 71, 81, 91) and at least one edge (16, 22, 33, 56, 78, 112) of each panel (11, 21, 32, 52, 74, 101, 109, 120), the resilient element (47, 66, 76, 94, 86, 95, 106, 113, 114, 117, 122) being arranged to temporarily deflect to permit a panel (11, 21, 32, 52, 74, 101, 109, 120) to be raised from below the grid member (10, 30, 45, 62, 70, 80, 85, 108, 125) into an installed position and to extend itself to hold such panel (11, 21, 32, 52, 74, 101, 109, 120) in position on the grid, characterized in that the grid member flanges (13, 31, 47, 63, 71, 81, 91) and/or the at least one edge (16, 22, 33, 56, 78, 112) of each panel (11, 21, 32, 52, 74, 101, 109, 120) develop a camming action to produce lateral movement of the resilient element (47, 66, 76, 94, 86, 95, 106, 113, 114, 117, 122) during downward panel removal movement.
A method for the production of haemagglutinin and/or neuraminidase derived from orthomyxovirus, comprising the following steps, in the indicated order: a) providing a fluid derived from a cell-based orthomyxovirus propagation culture or an egg-based orthomyxovirus propagation culture comprising said virus, b) clarifying the fluid comprising orthomyxovirus by applying centrifugation, tangential flow filtration, or depth filtration, resulting in a liquid harvest comprising said virus, c) reducing the volume of the liquid harvest obtained after step b) by a factor of at least 4 to obtain a concentrated liquid harvest, wherein this volume reducing step is carried out in one single step, d) solubilizing the orthomyxovirus being present in the liquid harvest by adding a detergent or mixture of detergents comprising a cationic detergent to the concentrated liquid harvest obtained in step c), wherein the final concentration of said cationic detergent is at least 2000 μg/ml, e) separating viral cores from the composition obtained after step d), f) optionally removing cationic detergent from the composition obtained after step e), g) purifying haemagglutinin and/or neuraminidase by applying chromatography, wherein step c) is followed directly by step d), and wherein no purification step that is directed at specifically purifying orthomyxovirus is carried out prior to step d). a) providing a fluid derived from a cell-based orthomyxovirus propagation culture or an egg-based orthomyxovirus propagation culture comprising said virus, b) clarifying the fluid comprising orthomyxovirus by applying centrifugation, tangential flow filtration, or depth filtration, resulting in a liquid harvest comprising said virus, c) reducing the volume of the liquid harvest obtained after step b) by a factor of at least 4 to obtain a concentrated liquid harvest, wherein this volume reducing step is carried out in one single step, d) solubilizing the orthomyxovirus being present in the liquid harvest by adding a detergent or mixture of detergents comprising a cationic detergent to the concentrated liquid harvest obtained in step c), wherein the final concentration of said cationic detergent is at least 2000 μg/ml, e) separating viral cores from the composition obtained after step d), f) optionally removing cationic detergent from the composition obtained after step e), g) purifying haemagglutinin and/or neuraminidase by applying chromatography,
A pet food composition comprising a glucose anti-metabolite and a source of selenium, wherein the composition is a nutritionally balanced pet food composition, wherein the source of selenium is an ingredient having at least 100 μg selenium per 100 g of the ingredient or an inorganic source of selenium; wherein the glucose anti-metabolite comprises a glucose anti-metabolite component selected from the group consisting of 2-deoxy-D- glucose; 5-thio-D-glucose; 3-O-methylglucose; 1,5-anhydro-D-glucitol; 2,5-anhydro-D-glucitol; 2,5-anhydro-D-mannitol; mannoheptulose; and mixtures and combinations thereof; and wherein the selenium content provided by the source of selenium is 1.25 to 10.0 μg per g of the composition.
Electrolytic cell including: - a container of non-conductive material suitable to contain a liquid formed by water and ionic compounds, - a first pole and a second pole, - a first electrode and a second electrode inserted inside said container and connected respectively to said first pole and said second pole, and - a generator capable of generating a potential difference between said first and second poles equal to the threshold potential difference B necessary to start an electrolysis process, characterized in that it further includes at least a third electrode which is also inserted inside the container and connected to the second pole, so that X electrodes are connected only to said second pole and are all placed equidistant from the only electrode connected to the first pole, said X electrodes being substantially identical in shape, size and material, in that said generator is able to generate a potential difference at least equal to X times said threshold potential difference B necessary to start an electrolysis process if only the first two electrodes (E1, E2) were present in the container, and is provided with a voltage regulator that allows the generated potential difference to be adjusted at least over the entire range between B and X*B, and in that the generator is either a DC voltage generator, in which case X>2, or an AC voltage generator, in which case X≥2, operating at a frequency ≥1 kHz and with a waveform preferably selected from square, sinusoidal, triangular and sawtooth. - a container of non-conductive material suitable to contain a liquid formed by water and ionic compounds, - a first pole and a second pole, - a first electrode and a second electrode inserted inside said container and connected respectively to said first pole and said second pole, and - a generator capable of generating a potential difference between said first and second poles equal to the threshold potential difference B necessary to start an electrolysis process, characterized in that it further includes at least a third electrode which is also inserted inside the container and connected to the second pole, so that X electrodes are connected only to said second pole and are all placed equidistant from the only electrode connected to the first pole, said X electrodes being substantially identical in shape, size and material, in that said generator is able to generate a potential difference at least equal to X times said threshold potential difference B necessary to start an electrolysis process if only the first two electrodes (E1, E2) were present in the container, and is provided with a voltage regulator that allows the generated potential difference to be adjusted at least over the entire range between B and X*B, and in that the generator is either a DC voltage generator, in which case X>2, or an AC voltage generator, in which case X≥2, operating at a frequency ≥1 kHz and with a waveform preferably selected from square, sinusoidal, triangular and sawtooth.
A pharmaceutical injecting device, comprising: a main body case having a pharmaceutical syringe installation component in which a pharmaceutical syringe is installed; a piston that is provided movably with respect to the pharmaceutical syringe installed in the pharmaceutical syringe installation component; a drive mechanism that drives the piston; and a display component that displays injection sites (P1-P10) at which the pharmaceutical in the pharmaceutical syringe is injected; characterized by a display controller that causes the display component to display a plurality of the injection sites (P1-P10) and to display at two or more injection sites (P1-P10) selectable displays (A1-A10, C3) indicating that those injection sites (P1-P10) are suitable for injection. a main body case having a pharmaceutical syringe installation component in which a pharmaceutical syringe is installed; a piston that is provided movably with respect to the pharmaceutical syringe installed in the pharmaceutical syringe installation component; a drive mechanism that drives the piston; and a display component that displays injection sites (P1-P10) at which the pharmaceutical in the pharmaceutical syringe is injected; characterized by a display controller that causes the display component to display a plurality of the injection sites (P1-P10) and to display at two or more injection sites (P1-P10) selectable displays (A1-A10, C3) indicating that those injection sites (P1-P10) are suitable for injection.
A pyrazole derivative according to Formula, wherein X 1 is selected from F and H; X 2 is selected from Cl and F; R 1 is selected from methyl and trifluoromethyl; R 2 is selected from the following groups: and as well as any pharmaceutically acceptable salt, hydrate, solvate, polymorph, tautomers, geometrical isomers, or optically active isomers thereof.
Container of a cosmetic or medical product, comprising an outer casing inside which an element is housed to at least partially contain the product, to at least a part of the casing or of the element being constrained, in an inaccessible position during the normal use of the product by an end user, an RFID chip, wherein the outer casing has an identifier of the position of the RFID chip in the container, so that a user can univocally identify the position of the RFID chip simply by viewing the outer casing of the container, the position of the RFID chip being used by the user tc position an RFID chip reader that is a smartphone, a tablet or a notebook in proximity of the RFID chip and access the information contained therein, the product containment element isolating the product from contact with the casing, the RFID chip being positioned in a gap defined between at least a part of said casing and the containment element.
A coring tool, comprising: a coring bit comprising an inner gage and an outer gage; and a sponge material positioned to at least partially surround a core sample cut by the coring bit; characterised in that a radial distance between an inner surface of the sponge material and the inner gage of the coring bit is between 0.2 mm and 1.5 mm along at least 75% of a longitudinal length of the sponge material; and wherein a distance between a center of curvature of the inner gage and a center of curvature of the outer gage is about 0.3 mm or less. a coring bit comprising an inner gage and an outer gage; and a sponge material positioned to at least partially surround a core sample cut by the coring bit; characterised in that a radial distance between an inner surface of the sponge material and the inner gage of the coring bit is between 0.2 mm and 1.5 mm along at least 75% of a longitudinal length of the sponge material; and wherein a distance between a center of curvature of the inner gage and a center of curvature of the outer gage is about 0.3 mm or less.