Irradiation system for ophthalmological applications with irradiation of tissue, comprising the following components: a. at least one radiation source for a primary radiation within the range from 300 nm to 800 nm, b. an optical system with at least two lenses (2, 4) and devices, in order to direct the radiation at a predetermined distance towards the tissue to be irradiated, wherein means are provided in order to adjust a temporally and/or spatially variable intensity distribution of the radiation, c. at least one diaphragm which is designed and arranged in such a way that together with the optical system it generates a predetermined irradiation region, d. at least one beam-splitter which couples out a part of the radiation for measuring or monitoring purposes and/or is configured for observation purposes and/or for a real-time diagnosis and/or for bringing said primary radiation together with a further radiation of a different wavelength from a further radiation source, e. a controller for controlling or regulating at least one of the radiation sources, including at least one sensor, f. an electrical power pack for supplying power to the irradiation system, g. a mechanical stand for supporting an irradiation unit which includes at least the components stated in features a., b., c., d., in relation to the tissue to be irradiated, h. a display device for displaying data that are relevant for the irradiation system, such as the emission of radiation, treatment parameters or possible misadjustments, i. an electronic interface between the controller and an external computer for the purpose of transmitting data such as, for example, duration of irradiation, dose, light distribution, measured data, data from databases, j. an interface or an input device for the input of data by a user, such as, for example, irradiation times, irradiation dose, characterized in that k. the irradiation system is configured for biomechanical stabilisation of the cornea of an eye, into which a photosensitiser, such as riboflavin, has been introduced, l. wherein the data input into the interface relate to biomechanical stabilisation of the cornea with the photosensitizer, such as riboflavin, and m. wherein the controller is configured to control or to regulate the at least one radiation source, for providing radiation according to the input data in relation to biomechanical stabilisation of the cornea with the photosensitiser, n. wherein the at least one diaphragm is controllable in order to adjust the irradiation region. a. at least one radiation source for a primary radiation within the range from 300 nm to 800 nm, b. an optical system with at least two lenses (2, 4) and devices, in order to direct the radiation at a predetermined distance towards the tissue to be irradiated, wherein means are provided in order to adjust a temporally and/or spatially variable intensity distribution of the radiation, c. at least one diaphragm which is designed and arranged in such a way that together with the optical system it generates a predetermined irradiation region, d. at least one beam-splitter which couples out a part of the radiation for measuring or monitoring purposes and/or is configured for observation purposes and/or for a real-time diagnosis and/or for bringing said primary radiation together with a further radiation of a different wavelength from a further radiation source, e. a controller for controlling or regulating at least one of the radiation sources, including at least one sensor, f. an electrical power pack for supplying power to the irradiation system, g. a mechanical stand for supporting an irradiation unit which includes at least the components stated in features a., b., c., d., in relation to the tissue to be irradiated, h. a display device for displaying data that are relevant for the irradiation system, such as the emission of radiation, treatment parameters or possible misadjustments, i. an electronic interface between the controller and an external computer for the purpose of transmitting data such as, for example, duration of irradiation, dose, light distribution, measured data, data from databases, j. an interface or an input device for the input of data by a user, such as, for example, irradiation times, irradiation dose, characterized in that k. the irradiation system is configured for biomechanical stabilisation of the cornea of an eye, into which a photosensitiser, such as riboflavin, has been introduced, l. wherein the data input into the interface relate to biomechanical stabilisation of the cornea with the photosensitizer, such as riboflavin, and m. wherein the controller is configured to control or to regulate the at least one radiation source, for providing radiation according to the input data in relation to biomechanical stabilisation of the cornea with the photosensitiser, n. wherein the at least one diaphragm is controllable in order to adjust the irradiation region.