mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula I, or a pharmaceutically acceptable salt, hydrate, or solvate of: wherein: R is independently OR 1, OC R 2, OC NHR 2, OS(O 2)R 2, NHS 2 R 2, NR 3 R 4, NHC R 5; R' and R" are independently H, F, Cl or OMe; each R 1 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, wherein said alkyl, cycloalkyl are optionally substituted with 1 to 4 groups selected from halo, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy; each R 2 is independently C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, heterocyclyl, heteroaryl or aryl, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 acyloxy, CF 3, NO 2, CN and NH 2; each R 3 and R 4 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, heterocyclyl heteroaryl, aryl; or R 3 and R 4 taken together with the nitrogen to which they are attached, form a 4- to 8-membered heterocyclyl or heteroaryl with 1 to 3 additional heteroatoms selected from O, S, or N, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, CF 3, NO 2, CN; each R 5 is independently C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, heteroaryl, aryl, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 acyloxy, CF 3, NO 2, CN and NH 2; Ring A is wherein, Y = O, S, SO, and SO 2; p is 1, or 2; q is 1, or 2. R is independently OR 1, OC R 2, OC NHR 2, OS(O 2)R 2, NHS 2 R 2, NR 3 R 4, NHC R 5; R' and R" are independently H, F, Cl or OMe; each R 1 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, wherein said alkyl, cycloalkyl are optionally substituted with 1 to 4 groups selected from halo, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy; each R 2 is independently C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, heterocyclyl, heteroaryl or aryl, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 acyloxy, CF 3, NO 2, CN and NH 2; each R 3 and R 4 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, heterocyclyl heteroaryl, aryl; or R 3 and R 4 taken together with the nitrogen to which they are attached, form a 4- to 8-membered heterocyclyl or heteroaryl with 1 to 3 additional heteroatoms selected from O, S, or N, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, CF 3, NO 2, CN; each R 5 is independently C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, heteroaryl, aryl, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 acyloxy, CF 3, NO 2, CN and NH 2; Ring A is wherein, Y = O, S, SO, and SO 2; p is 1, or 2; q is 1, or 2. Y = O, S, SO, and SO 2; p is 1, or 2; q is 1, or 2.
A method of generating reduced-noise image frames based on image frames received from a digital camera pipeline (1302, 1304), the method comprising: in a digital processing resource comprising at least one digital processor: A. receiving at least one frame of image pixel data from a digital camera pipeline; B. receiving image metadata corresponding to the at least one received frame; and C. executing temporal de-noising operations for at least selected pixels of the at least one received frame of image pixel data utilizing the image metadata and a noise model wherein executing temporal de-noising operations comprises: evaluating (603.1) the noise model to estimate the noise present in a selected pixel from the at least one received frame, wherein the image metadata is an input to the evaluating of the noise model to estimate the noise present in the selected pixel; blending (603.2) data from a persistent image buffer with data from the at least one received frame; updating (603.3) data in the persistent image buffer; and outputting (603.4) the blended pixel data to a reduced-noise frame buffer, thereby to generate a reduced-noise image frame, wherein the noise model is a source for information useable in executing the blending. A. receiving at least one frame of image pixel data from a digital camera pipeline; B. receiving image metadata corresponding to the at least one received frame; and C. executing temporal de-noising operations for at least selected pixels of the at least one received frame of image pixel data utilizing the image metadata and a noise model wherein executing temporal de-noising operations comprises: evaluating (603.1) the noise model to estimate the noise present in a selected pixel from the at least one received frame, wherein the image metadata is an input to the evaluating of the noise model to estimate the noise present in the selected pixel; blending (603.2) data from a persistent image buffer with data from the at least one received frame; updating (603.3) data in the persistent image buffer; and outputting (603.4) the blended pixel data to a reduced-noise frame buffer, thereby to generate a reduced-noise image frame, wherein the noise model is a source for information useable in executing the blending. evaluating (603.1) the noise model to estimate the noise present in a selected pixel from the at least one received frame, wherein the image metadata is an input to the evaluating of the noise model to estimate the noise present in the selected pixel; blending (603.2) data from a persistent image buffer with data from the at least one received frame; updating (603.3) data in the persistent image buffer; and outputting (603.4) the blended pixel data to a reduced-noise frame buffer, thereby to generate a reduced-noise image frame, wherein the noise model is a source for information useable in executing the blending.
A detergent composition for machine dishwashing comprising Z1) ethoxylated glycerol esters of formula, prepared from ethylene oxide and one or more triglycerides of formula in the presence of a calcium catalyst, characterized in that R 1, R 2 and R 3 in formulae and are equal or different and are independently selected from saturated or unsaturated, linear or branched C 7 -C 24 alkyl chains; m, n and o in formula are equal or different and are each independently an integer number from 1 to 200, preferably from 1 to 80, more preferably from 2 to 70, with the proviso that the number-average of the sum of m + n + o is greater than 5, preferably from 20 to 70, more preferably from 30 to 60; and the calcium catalyst is a catalyst obtainable by a reaction involving calcium hydroxide and a carboxylic acid comprising 3 to 40 carbon atoms, wherein the molar ratio of calcium hydroxide to carboxylic acid in the preparation of the catalyst is from 1:1 to 1:5. Z1) ethoxylated glycerol esters of formula, prepared from ethylene oxide and one or more triglycerides of formula in the presence of a calcium catalyst, characterized in that R 1, R 2 and R 3 in formulae and are equal or different and are independently selected from saturated or unsaturated, linear or branched C 7 -C 24 alkyl chains; m, n and o in formula are equal or different and are each independently an integer number from 1 to 200, preferably from 1 to 80, more preferably from 2 to 70, with the proviso that the number-average of the sum of m + n + o is greater than 5, preferably from 20 to 70, more preferably from 30 to 60; and the calcium catalyst is a catalyst obtainable by a reaction involving calcium hydroxide and a carboxylic acid comprising 3 to 40 carbon atoms, wherein the molar ratio of calcium hydroxide to carboxylic acid in the preparation of the catalyst is from 1:1 to 1:5. R 1, R 2 and R 3 in formulae and are equal or different and are independently selected from saturated or unsaturated, linear or branched C 7 -C 24 alkyl chains; m, n and o in formula are equal or different and are each independently an integer number from 1 to 200, preferably from 1 to 80, more preferably from 2 to 70, with the proviso that the number-average of the sum of m + n + o is greater than 5, preferably from 20 to 70, more preferably from 30 to 60; and the calcium catalyst is a catalyst obtainable by a reaction involving calcium hydroxide and a carboxylic acid comprising 3 to 40 carbon atoms, calcium hydroxide and a carboxylic acid comprising 3 to 40 carbon atoms, wherein the molar ratio of calcium hydroxide to carboxylic acid in the preparation of the catalyst is from 1:1 to 1:5.
A modified cellobiose dehydrogenase or its functional flavodehydrogenase domain having glucose oxidation activity and a reduced maltose oxidation activity as compared to the unmodified wild-type CDH or its functional flavodehydrogenase domain, characterised in that the modification is a modification of at least one amino acid corresponding to any one of amino acids 310-320, 342-347, 599-625 or 718-725 of the M. thermophilum cellobiose dehydrogenase of SEQ ID NO: 1, or any combination thereof.
Rubber composition based on at least: - an elastomer matrix comprising more than 50 phr of a copolymer containing ethylene units and 1,3-diene units, the ethylene units in the copolymer representing more than 50 mol% of the monomer units of the copolymer, - a 1,3-dipolar compound corresponding to the formula: in which: ∘ Q represents an arenediyl ring optionally substituted by one or more identical or different, preferably saturated, linear or branched aliphatic hydrocarbon chains, which are optionally substituted or interrupted by one or more heteroatoms, ∘ E represents a divalent hydrocarbon group optionally comprising one or more heteroatoms, - a filler comprising predominantly silica, and - a crosslinking system comprising at least one radical polymerization initiator, and a cocrosslinking agent selected from the group consisting of (meth)acrylate compounds, maleimide compounds, allyl compounds, vinyl compounds and mixtures thereof. - an elastomer matrix comprising more than 50 phr of a copolymer containing ethylene units and 1,3-diene units, the ethylene units in the copolymer representing more than 50 mol% of the monomer units of the copolymer, - a 1,3-dipolar compound corresponding to the formula: in which: ∘ Q represents an arenediyl ring optionally substituted by one or more identical or different, preferably saturated, linear or branched aliphatic hydrocarbon chains, which are optionally substituted or interrupted by one or more heteroatoms, ∘ E represents a divalent hydrocarbon group optionally comprising one or more heteroatoms, ∘ Q represents an arenediyl ring optionally substituted by one or more identical or different, preferably saturated, linear or branched aliphatic hydrocarbon chains, which are optionally substituted or interrupted by one or more heteroatoms, ∘ E represents a divalent hydrocarbon group optionally comprising one or more heteroatoms, - a filler comprising predominantly silica, and - a crosslinking system comprising at least one radical polymerization initiator, and a cocrosslinking agent selected from the group consisting of (meth)acrylate compounds, maleimide compounds, allyl compounds, vinyl compounds and mixtures thereof.
Device for continuously manufacturing flat glass, in which a semifluid glass sheet is passed from a melting tank in a conveying direction in a calibrated manner to a slightly downwardly inclined to horizontal transport path, on which said sheet solidifies by cooling and to the other end of which a conveying device for the rigidified flat glass is connected, the transport path having a porous cover layer through which a liquid rises under the rigidifying glass sheet, the heat of which forms from the liquid a steam cushion on which the glass sheet contactlessly floats, excess steam flowing off laterally between cover layer regions, characterised in that the cover layer of the transport path predominantly consists of alkaline earth silicate hydrate or alkaline earth aluminate hydrate having a porosity of over 60 %, is grooved on the lower face for steam to escape, and contacts the liquid by way of web regions extending transverse to the conveying direction and conveys it to the surface by capillary action.
A stretcher loading assembly including a support member operatively attachable to an aircraft floor; an elongate rail member attached to the support member; an elongate traverse beam movably attached to the rail member; characterised in a trolley assembly movably attached to the traverse beam, the trolley assembly including lifting means movable between a lowered position and a raised position, the lifting means adapted to support a stretcher in the raised position; wherein the support member is at least twice as wide as the rail member, and wherein the stretcher loading assembly further includes a turntable member, the turntable member configured to be located between the support member and the aircraft floor so that when the support member is operatively attached to the aircraft floor, the turntable member enables the support member to be rotated relative to the aircraft floor. a support member operatively attachable to an aircraft floor; an elongate rail member attached to the support member; an elongate traverse beam movably attached to the rail member; characterised in a trolley assembly movably attached to the traverse beam, the trolley assembly including lifting means movable between a lowered position and a raised position, the lifting means adapted to support a stretcher in the raised position; wherein the support member is at least twice as wide as the rail member, and wherein the stretcher loading assembly further includes a turntable member, the turntable member configured to be located between the support member and the aircraft floor so that when the support member is operatively attached to the aircraft floor, the turntable member enables the support member to be rotated relative to the aircraft floor.
A flat tube for a heat exchanger, with two open ends defining its longitudinal direction, comprising a first wall and a second wall which are flat and parallel to each other, thereby delimiting the inner space of the tube, and further comprising an inner fin located between the first and the second walls (1, 2), wherein one of the lateral sides of the first wall comprises a main fold running along the longitudinal direction, wherein arms of the main fold form a slit facing the inner space of the tube, and the lateral side of the second wall is bent to cover the main fold, whereas the slit of the main fold is displaced towards the plane of the first wall or the second wall, characterized in that a lateral side end of the fin adjacent to the main fold is placed inside the slit of the main fold, and wherein both sides of the fin are compressed by the arms of the main fold.
A lighting system for a loading dock where a material handling device is used to load or unload a vehicle parked at the loading dock, the lighting system comprising: a motion sensing system to be spaced apart from the material handling device, the motion sensing system to provide an operation signal in response to a movement of the material handling device; and a lamp to be operatively connected in signal communication with the motion sensing system so as to receive the operation signal from the motion sensing system; the motion sensing system to provide an operation signal in response to detecting the material handling device undergoing a change in travel direction within the vehicle between moving in a forward direction farther into the vehicle and moving in a reverse direction within the vehicle opposite the forward direction; characterized in that: the lamp is to illuminate the interior of the vehicle, and the lamp is to switch to a first illuminating mode in response to the operation signal indicating the material handling device is moving in the forward direction, and the lamp is to switch to a second illuminating mode in response to the operation signal indicating the material handling device is moving in the reverse direction, wherein the lamp is adapted to dim or redirect the lamp's light output when the lamp is in the second illuminating mode. a motion sensing system to be spaced apart from the material handling device, the motion sensing system to provide an operation signal in response to a movement of the material handling device; and a lamp to be operatively connected in signal communication with the motion sensing system so as to receive the operation signal from the motion sensing system; the motion sensing system to provide an operation signal in response to detecting the material handling device undergoing a change in travel direction within the vehicle between moving in a forward direction farther into the vehicle and moving in a reverse direction within the vehicle opposite the forward direction; characterized in that: the lamp is to illuminate the interior of the vehicle, and the lamp is to switch to a first illuminating mode in response to the operation signal indicating the material handling device is moving in the forward direction, and the lamp is to switch to a second illuminating mode in response to the operation signal indicating the material handling device is moving in the reverse direction, wherein the lamp is adapted to dim or redirect the lamp's light output when the lamp is in the second illuminating mode.
Striking mechanism unit for a repeater striking mechanism, said striking mechanism unit comprising a drive plate with a pipe mounted to pivot about a pivot axis, said drive plate carrying a click including a hook with a beak returned towards said axis by a spring, said click being arranged to be movable against said spring by the action of a pin which is comprised in a detent ratchet of said striking mechanism unit and arranged to cooperate with a main strike control mechanism, and comprising a pipe ratchet arranged to be mounted to pivot on a said pipe about said axis and to cooperate, in a toothing comprised therein, with a said beak which, depending on the position thereof, allows or prevents the pivoting of said pipe ratchet, said pipe ratchet being mounted to pivot integrally about said axis with a first hour ratchet arranged to cooperate with a first lifting-piece for driving a hammer comprised in said repeater striking mechanism in order to release a first sound transmission called the main strike, said striking mechanism unit comprising a release wheel for the release of another sound transmission called the secondary strike which is different from said main strike, said release wheel and said detent ratchet being independent of each other and each controlled by different control means selected to actuate, respectively said secondary strike or said main strike, characterized in that said release wheel and said detent ratchet are both arranged to act, but never at the same time, on said hook to allow the transmission of energy to a sound mechanism to play, respectively, said secondary or alarm strike, or said main strike.
A method of forming a three-dimensional component, comprising: providing a first composition comprising a plurality of foam particles dispersed or suspended in a liquid polymerizable composition; polymerizing a first portion of the liquid polymerizable composition, forming a first layer including a first portion of a polymeric material which is the polymerized reaction product of the polymerizable composition, the first portion of the polymeric material at least partially encapsulating a first portion of the plurality of foam particles; repeating the polymerizing and forming for a second iteration, polymerizing a second portion of the liquid polymerizable composition, forming a second layer including a second portion of the polymeric material at least partially encapsulating a second portion of the plurality of foam particles, and bonding the second layer to the first layer; and repeating the polymerizing, forming and bonding for at least a third iteration, forming a three-dimensional component having at least three layers, each layer including foam particles at least partially encapsulated by the first polymeric material and being bonded to another layer, the total number of layers being equal to the total number of iterations conducted. providing a first composition comprising a plurality of foam particles dispersed or suspended in a liquid polymerizable composition; polymerizing a first portion of the liquid polymerizable composition, forming a first layer including a first portion of a polymeric material which is the polymerized reaction product of the polymerizable composition, the first portion of the polymeric material at least partially encapsulating a first portion of the plurality of foam particles; repeating the polymerizing and forming for a second iteration, polymerizing a second portion of the liquid polymerizable composition, forming a second layer including a second portion of the polymeric material at least partially encapsulating a second portion of the plurality of foam particles, and bonding the second layer to the first layer; and repeating the polymerizing, forming and bonding for at least a third iteration, forming a three-dimensional component having at least three layers, each layer including foam particles at least partially encapsulated by the first polymeric material and being bonded to another layer, the total number of layers being equal to the total number of iterations conducted.
A braking arrangement, comprising: a torque plate comprising a torque tube and a back leg; an end plate comprising a torque pocket; a torque button comprising a head portion and a shaft portion, wherein the head portion is configured to extend at least partially into the torque pocket and the shaft portion is configured to extend through an aperture disposed in the back leg; and characterized by a bushing configured to be removably coupled between the shaft portion of the torque button and the back leg of the torque plate. a torque plate comprising a torque tube and a back leg; an end plate comprising a torque pocket; a torque button comprising a head portion and a shaft portion, wherein the head portion is configured to extend at least partially into the torque pocket and the shaft portion is configured to extend through an aperture disposed in the back leg; and characterized by a bushing configured to be removably coupled between the shaft portion of the torque button and the back leg of the torque plate.
Alcohol-free composition for use in a method of killing ectoparasites on a subject, said method comprising: topically administering said alcohol-free composition to an area on the subject where ectoparasites are present, wherein the composition comprises a pharmaceutically acceptable carrier and isopropyl myristate as the sole ectoparasiticidal agent present in an amount effective for killing ectoparasites at less than 70% (w/w), more than 20% (w/w) or at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% (w/w), and wherein further at least 75% of ectoparasite present are killed within 24 hours after a 10 minute exposure to the composition. topically administering said alcohol-free composition to an area on the subject where ectoparasites are present, wherein the composition comprises a pharmaceutically acceptable carrier and isopropyl myristate as the sole ectoparasiticidal agent present in an amount effective for killing ectoparasites at less than 70% (w/w), more than 20% (w/w) or at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% (w/w), and wherein further at least 75% of ectoparasite present are killed within 24 hours after a 10 minute exposure to the composition.