mhurhangee/ep-ind-claims huggingface dataset:
A computer-implemented method for classifying neurodegenerative disorder(s) and/or movement disorder(s) of a subject, the method comprising: receiving, from a memory, subject data of a subject, the subject data including one or more sets of MRI image data of a brain of the subject; processing one or more sets of MRI image data to extract one or more quantitative features for one or more regions, the one or more quantitative features for one or more regions includes a first quantitative feature for the one or more regions and a second quantitative feature for the one or more regions; classifying at least the one or more quantitative features for the one or more regions into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder, and/or heathy control; and generating a report including a classification of at least the one or more quantitative features, wherein the one or more quantitative features comprises one or more R2* features. receiving, from a memory, subject data of a subject, the subject data including one or more sets of MRI image data of a brain of the subject; processing one or more sets of MRI image data to extract one or more quantitative features for one or more regions, the one or more quantitative features for one or more regions includes a first quantitative feature for the one or more regions and a second quantitative feature for the one or more regions; classifying at least the one or more quantitative features for the one or more regions into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder, and/or heathy control; and generating a report including a classification of at least the one or more quantitative features, wherein the one or more quantitative features comprises one or more R2* features.
Applicator end piece for cosmetic product extending along a longitudinal extension direction, called principal direction, and comprising: - an external shell having an external surface and an internal surface, the external surface defining at least one application part, the internal surface delimiting a cavity, - a central element arranged inside the cavity, in at least one position, the internal surface of the external shell is spaced from the central element in a direction orthogonal to the longitudinal extension direction and in the longitudinal direction so as to define a free space enclosing the central element. - an external shell having an external surface and an internal surface, the external surface defining at least one application part, the internal surface delimiting a cavity, - a central element arranged inside the cavity, in at least one position, the internal surface of the external shell is spaced from the central element in a direction orthogonal to the longitudinal extension direction and in the longitudinal direction so as to define a free space enclosing the central element.
A rubber composition comprising a diene elastomer, a pre-hydrophobated silica, a blocked mercaptosilane, a resin, and a relatively low molecular weight polybutadiene functionalized with a hydroxyl functional group having a molecular weight Mw ranging from 1000 to 25000 g/gmol, wherein the pre-hydrophobated silica is hydrophobated prior to its addition to the rubber composition by treatment with at least one silane selected from the group consisting of alkylsilanes, alkoxysilanes, organoalkoxysilyl polysulfides and organomercaptoalkoxysilanes and optionally at least one dispersing aid selected from the group consisting of fatty acids, diethylene glycols, polyethylene glycols, fatty acid esters of hydrogenated or non-hydrogenated C 5 or C 6 sugars, polyoxyethylene derivatives of fatty acid esters of hydrogenated or non-hydrogenated C 5 or C 6 sugars, wherein the weight average molecular weight Mw is measured according to ASTM 3536.
A filter driver for use with an operating system, the filter driver comprising a kernel mode driver configured to intercept file system I/O requests before they reach a file system driver, wherein the filter driver is operable to: determine disk space utilization in relation to a plurality of disk space quotas; store said disk space quotas and said disk space utilization in a file structure; monitor disk I/O; prospectively evaluate the effect of said disk I/O on said disk space utilization, said effect being a revised disk space utilization in relation to said disk space quotas; terminate said disk I/O if said revised disk space utilization exceeds any of said disk space quotas; and execute a post-processing routine comprising an update of said file structure to reflect completion of said disk I/O if said revised disk space utilization does not exceed any of said disk space quotas; wherein in response to detecting that said disk I/O is executing at an interrupt request level (IRQL) of DISPATCH_LEVEL, the filter driver is further operable to queue the post-processing routine to a pool of worker threads that execute at an IRQL of PASSIVE_LEVEL. determine disk space utilization in relation to a plurality of disk space quotas; store said disk space quotas and said disk space utilization in a file structure; monitor disk I/O; prospectively evaluate the effect of said disk I/O on said disk space utilization, said effect being a revised disk space utilization in relation to said disk space quotas; terminate said disk I/O if said revised disk space utilization exceeds any of said disk space quotas; and execute a post-processing routine comprising an update of said file structure to reflect completion of said disk I/O if said revised disk space utilization does not exceed any of said disk space quotas; wherein in response to detecting that said disk I/O is executing at an interrupt request level (IRQL) of DISPATCH_LEVEL, the filter driver is further operable to queue the post-processing routine to a pool of worker threads that execute at an IRQL of PASSIVE_LEVEL.
A modified release composition for oral administration comprising a core having the form of a solid colloid, the colloid comprising a continuous phase comprising a hydrogel forming polymer and a disperse phase comprising cyclosporin A and an oil phase, the oil phase comprising an oil and one or more surfactants, wherein: the oil and surfactant have an HLB of up to 10; the oil comprises medium chain triglyceride; the surfactant comprises a surfactant selected from: fatty acid glycerides, polyethylene glycol fatty acid esters, propylene glycol fatty acid esters, fatty acid lactic acid ester, sucrose fatty acid esters, sorbitan fatty acid esters, polyethylene glycol fatty alcohol ethers, ethylene oxide-propylene oxide block co-polymers and polyoxyethylene ethers; the composition comprises a first coating and a second coating outside the first coating; and wherein (i) the first coating comprises a water-soluble cellulose ether or a water-soluble derivative of a cellulose ether, wherein the first coating is present in an amount corresponding to a weight gain of the composition due to the first coating of from 1% to 20% by weight based upon the weight of the composition prior to applying the first coating; and (ii) the second coating comprises a modified release coating to control or modulate release of the cyclosporin A from the composition selected from a controlled release polymer, a sustained release polymer, an enteric polymer, a pH independent polymer, a pH dependent polymer and a polymer specifically susceptible to degradation by bacterial enzymes in the gastrointestinal tract, or a combination of two or more such polymers. the oil and surfactant have an HLB of up to 10; the oil comprises medium chain triglyceride; the surfactant comprises a surfactant selected from: fatty acid glycerides, polyethylene glycol fatty acid esters, propylene glycol fatty acid esters, fatty acid lactic acid ester, sucrose fatty acid esters, sorbitan fatty acid esters, polyethylene glycol fatty alcohol ethers, ethylene oxide-propylene oxide block co-polymers and polyoxyethylene ethers; the composition comprises a first coating and a second coating outside the first coating; (i) the first coating comprises a water-soluble cellulose ether or a water-soluble derivative of a cellulose ether, wherein the first coating is present in an amount corresponding to a weight gain of the composition due to the first coating of from 1% to 20% by weight based upon the weight of the composition prior to applying the first coating; and (ii) the second coating comprises a modified release coating to control or modulate release of the cyclosporin A from the composition selected from a controlled release polymer, a sustained release polymer, an enteric polymer, a pH independent polymer, a pH dependent polymer and a polymer specifically susceptible to degradation by bacterial enzymes in the gastrointestinal tract, or a combination of two or more such polymers.
A pharmaceutical composition comprising: a) granules comprising: i) entecavir or a pharmaceutically acceptable salt thereof; ii) at least one intra-granular pharmaceutically acceptable excipient, wherein the granules do not comprise povidone, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, gelatin, guar gum, and xanthan gum and mixtures thereof; b) at least one extra-granular pharmaceutical excipient wherein an extra-granular pharmaceutical excipient is a lubricant selected from the group consisting of: magnesium stearate, calcium stearate, zinc stearate, sodium stearate, stearic acid, aluminum stearate, glyceryl behenate, hydrogenated vegetable oil and combinations thereof; c) a moisture barrier coating; wherein said composition is suitable for the treatment of hepatitis B virus infection. a) granules comprising: i) entecavir or a pharmaceutically acceptable salt thereof; ii) at least one intra-granular pharmaceutically acceptable excipient, wherein the granules do not comprise povidone, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, gelatin, guar gum, and xanthan gum and mixtures thereof; i) entecavir or a pharmaceutically acceptable salt thereof; ii) at least one intra-granular pharmaceutically acceptable excipient, wherein the granules do not comprise povidone, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, gelatin, guar gum, and xanthan gum and mixtures thereof; b) at least one extra-granular pharmaceutical excipient wherein an extra-granular pharmaceutical excipient is a lubricant selected from the group consisting of: magnesium stearate, calcium stearate, zinc stearate, sodium stearate, stearic acid, aluminum stearate, glyceryl behenate, hydrogenated vegetable oil and combinations thereof; c) a moisture barrier coating;
A method for diagnosing Systemic Lupus Erythematosus, or monitoring SLE disease activity comprising (a) determining a level of: erythrocyte C4d (EC4d) marker and B-cell C4d (BC4d) marker in a biological sample from a subject; and an anti-mutated citrullinated vimentin (anti-MCV) antibody marker in a biological sample from the subject; (b) calculating an SLE risk score by adjusting the level of one or more of the markers by one or more transformation analyses; (c) comparing the SLE risk score to a standard; and (d) one or more of diagnosing the subject as having SLE based on the comparison; determining a level of SLE disease activity based on the comparison; providing the comparison to an entity for diagnosis of SLE; and providing the comparison to an entity for monitoring SLE disease activity. (a) determining a level of: erythrocyte C4d (EC4d) marker and B-cell C4d (BC4d) marker in a biological sample from a subject; and an anti-mutated citrullinated vimentin (anti-MCV) antibody marker in a biological sample from the subject; erythrocyte C4d (EC4d) marker and B-cell C4d (BC4d) marker in a biological sample from a subject; and an anti-mutated citrullinated vimentin (anti-MCV) antibody marker in a biological sample from the subject; (b) calculating an SLE risk score by adjusting the level of one or more of the markers by one or more transformation analyses; (c) comparing the SLE risk score to a standard; and (d) one or more of diagnosing the subject as having SLE based on the comparison; determining a level of SLE disease activity based on the comparison; providing the comparison to an entity for diagnosis of SLE; and providing the comparison to an entity for monitoring SLE disease activity. diagnosing the subject as having SLE based on the comparison; determining a level of SLE disease activity based on the comparison; providing the comparison to an entity for diagnosis of SLE; and providing the comparison to an entity for monitoring SLE disease activity.
A Treatment appliance comprising a device for generating an electrical or electromagnetic field substantially present in a handle comprising coils connected in series and comprising a hollow glass probe filled with at least one electrically conductive gas, the electrical or electromagnetic field being formed between a probe and the body of a person or an animal or a metal, characterized in that the field voltage and current intensity within the electrical or electromagnetic field increases from a low field voltage and current intensity to a higher field voltage and current intensity only when approaching the body or the metal, wherein a minimal current flows at the low field voltage and current intensity, wherein a discharge occurs and initiates an impulse, so that the current intensity increases to a higher current intensity within a unit of time.
A method of producing a collagen material, wherein the method comprises; a step for preparing a collagen gel fragment with a string shape orientated by collagen solution being extruded through a nozzle into a container containing a phosphate buffered saline and giving a flow of a fixed direction to collagen solution during a process of gelating a collagen solution, a step for arranging the collagen gel fragments in a desired shape, and a step for drying the collagen gel fragments arranged in the desired shape to couple with the collagen gel fragments each other.
A method for identifying an individual as a candidate for cancer therapy with a p110α inhibitor, comprising: testing a first body sample obtained from the individual, wherein the first body sample is a first tissue that is suspected of being neoplastic and a second body sample obtained from the individual wherein the second body sample is a second tissue that is not suspected of being neoplastic for a non-synonymous, intragenic, activating mutation in exon 1,9 or 20 of a PIK3CA coding sequence, or the corresponding protein sequence, wherein a wild-type PIK3CA coding sequence comprises the sequence shown in SEQ ID NO:2; and identifying the individual as candidate for cancer therapy with a p110α inhibitor if a non-synonymous, intragenic, activating mutation in PIK3CA or in a PIK3CA coding sequence is determined in the first body sample and if the non-synonymous, intragenic, activating mutation in PIK3CA or in a PIK3CA coding sequence is absent in the second body sample. testing a first body sample obtained from the individual, wherein the first body sample is a first tissue that is suspected of being neoplastic and a second body sample obtained from the individual wherein the second body sample is a second tissue that is not suspected of being neoplastic for a non-synonymous, intragenic, activating mutation in exon 1,9 or 20 of a PIK3CA coding sequence, or the corresponding protein sequence, wherein a wild-type PIK3CA coding sequence comprises the sequence shown in SEQ ID NO:2; and identifying the individual as candidate for cancer therapy with a p110α inhibitor if a non-synonymous, intragenic, activating mutation in PIK3CA or in a PIK3CA coding sequence is determined in the first body sample and if the non-synonymous, intragenic, activating mutation in PIK3CA or in a PIK3CA coding sequence is absent in the second body sample.
Baling press having a chassis for the support on the ground, a collecting device for collecting harvested material from the ground, a bale forming device for forming the collected harvested material into bales, a wrapping device for enwrapping the bale with a net, a foil or the like, as well as a slope compensation device for tilting the wrapping device and/or the bale forming device against a hill slope of the ground, characterized in that the slope compensation device comprises at least one transverse inclination actuator (19; 22) for tilting the bale forming device and/or the wrapping device transversely to the driving direction about at least one horizontal transverse inclination tilting axis approximately extending in the driving direction, wherein the chassis is formed to be height-adjustable with respect to a chassis part, on which the bale forming device and/or the wrapping device is supported, wherein right and left chassis parts are formed to be height-adjustable independently from one another and/or in opposite directions with respect to one another.
An annular combustion system segment, comprising: a first integrated combustor nozzle including an inner liner segment, an outer liner segment, a first side wall, a second side wall, a plurality of premixing channels (132, 134) defined therebetween, a plurality of injection outlets in fluid communication with the plurality of premixing channels (132, 134), and a downstream end portion defining a first turbine nozzle; a second integrated combustor nozzle adj acent to the first integrated combustor nozzle, the second integrated combustor nozzle including an inner liner segment, an outer liner segment, a first side wall, a second side wall, a plurality of premixing channels (132, 134) defined therebetween, a plurality of injection outlets in fluid communication with the plurality of premixing channels (132, 134), and a downstream end portion defining a second turbine nozzle; and a first fuel injection module including a fuel nozzle portion disposed between the second side wall of the first integrated combustor nozzle and the first side wall of the second integrated combustor nozzle, and at least one fuel injection lance in fluid communication with a fuel supply and at least one of the plurality of premixing channels (132, 134) of the first integrated combustor nozzle and the plurality of premixing channels (132, 134) of the second integrated combustor nozzle. a first integrated combustor nozzle including an inner liner segment, an outer liner segment, a first side wall, a second side wall, a plurality of premixing channels (132, 134) defined therebetween, a plurality of injection outlets in fluid communication with the plurality of premixing channels (132, 134), and a downstream end portion defining a first turbine nozzle; a second integrated combustor nozzle adj acent to the first integrated combustor nozzle, the second integrated combustor nozzle including an inner liner segment, an outer liner segment, a first side wall, a second side wall, a plurality of premixing channels (132, 134) defined therebetween, a plurality of injection outlets in fluid communication with the plurality of premixing channels (132, 134), and a downstream end portion defining a second turbine nozzle; and a first fuel injection module including a fuel nozzle portion disposed between the second side wall of the first integrated combustor nozzle and the first side wall of the second integrated combustor nozzle, and at least one fuel injection lance in fluid communication with a fuel supply and at least one of the plurality of premixing channels (132, 134) of the first integrated combustor nozzle and the plurality of premixing channels (132, 134) of the second integrated combustor nozzle.
Flexible tubing pump for accommodation of at least one section of a flexible tubing with at least one stator and at least one rotor which pivots around an axis of rotation in the stator, wherein the rotor comprises a rotating front cover or disk configured as rotor cover with a rotor handle to manually turn the rotor, wherein the stator surrounds or confines the rotor in at least some sections of the circumference of the rotor, by means of a recessed first opening intended for inserting the flexible tubing into the pump, and a therefrom separately located recessed second opening intended for leading the flexible tubing out of the tubing pump, characterized in that - a section of the tubing pump or of the stator formed between the first opening and the second opening comprises an edge or an area in proximity of the second opening which is nearer to the axis of rotation of the rotor than all other sections of the stator, - wherein the edge or area is not in the raceway of fluid movement devices or rollers of the tubing pump or of its rotor. - a section of the tubing pump or of the stator formed between the first opening and the second opening comprises an edge or an area in proximity of the second opening which is nearer to the axis of rotation of the rotor than all other sections of the stator, - wherein the edge or area is not in the raceway of fluid movement devices or rollers of the tubing pump or of its rotor.
System for reducing impurities on an anode or cathode side of a fuel cell, which system comprises - the anode or cathode of a fuel cell, - a fuel or oxidizer feed line (11, 12) for feeding fuel or oxidizer to the anode or cathode, respectively, - a circulation line in flow connection with the anode or cathode, for circulating part of the fuel or oxidizer along the circulation line, and - at least one filter, which is arranged on the said circulation line, for removing impurities of the fuel or oxidizer, characterized in that the circulation line is fitted in parallel with the anode or cathode of the fuel cell, relative to the direction of flow of the fuel or oxidizer, in such a way that part of the fuel or oxidizer can be circulated along the circulation line past the fuel cell's anode or cathode. - the anode or cathode of a fuel cell, - a fuel or oxidizer feed line (11, 12) for feeding fuel or oxidizer to the anode or cathode, respectively, - a circulation line in flow connection with the anode or cathode, for circulating part of the fuel or oxidizer along the circulation line, and - at least one filter, which is arranged on the said circulation line, for removing impurities of the fuel or oxidizer,