A compound of Formula: wherein: - R 1 is selected from the group consisting of F, Cl, Br, I, -CN, -CF3, -CCl 3, - CHF 2, -CHCl 2, -CH 2 F, -CH 2 Cl, -OCF 3 and -OCCl 3; - R 2 is selected from the group consisting of C 2-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 5-6 cycloalkenyl, -C(=O)-C 1-5 alkyl, -C(=O)-C 1-5 alkenyl, -C(=O)-C 1-5 alkynyl, -C(=O)-C 3-5 cycloalkyl and -C(=O)-C 5 cycloalkenyl, each of which may be optionally substituted with one or more, identical or different, substituents R 6; - R 3 is selected from the group consisting of hydrogen, deuterium, tritium, F, Cl, Br, I, -CN, -CF 3, -CCl 3, -CHF 2, -CHCl 2, -CH 2 F, -CH 2 Cl, -OCF 3, -OCCl 3 and isocyanide; - R 4 is selected from the group consisting of C 1-5 alkyl, C 1-5 alkenyl, C 1-5 alkynyl, C 3-5 cycloalkyl, C 5 cycloalkenyl, each of which may be optionally substituted with one or more, identical or different, substituents R 7; - R 5 is selected from the group consisting of H, C 1-5 alkyl optionally substituted with one or more, identical or different, substituents R 11, C 2-5 alkenyl, C 2-5 alkynyl, C 3-6 cycloalkyl optionally substituted with one or more, identical or different, substituents R 11, phenyl optionally substituted with one or more, identical or different, substituents R 12 and benzyl optionally substituted with one or more, identical or different, substituents R 12; - R 6 is independently selected from the group consisting of hydrogen, deuterium, tritium, F, Cl, Br, I, -CN, isocyanide, -O-C 1-3 alkyl, -S-C 1-3 alkyl, -CH 2 -OH, -CH 2 -O-C 1-3 alkyl, -O-CH 2 -Ph, -CH 2 -SH and -CH 2 -S-C 1-3 alkyl; - R 7 is independently selected from the group consisting of deuterium, tritium, F, Cl, Br, I, -CN, isocyanide, -O-C 1-3 alkyl, -S-C 1-3 alkyl, -CH 2 -O-C 1-3 alkyl and -CH 2 -S-C 1-3 alkyl; - R 11 is independently selected from the group consisting of deuterium and F; - R 12 is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I and F; and - n is an integer 0, 1, 2 or 3; or a pharmaceutically acceptable salt, hydrate, polymorph, tautomer, or solvate thereof, for use in treating, ameliorating and/or preventing a neuromuscular disorder, and/or for use in reversing and/or ameliorating a neuromuscular blockade. - R 1 is selected from the group consisting of F, Cl, Br, I, -CN, -CF3, -CCl 3, - CHF 2, -CHCl 2, -CH 2 F, -CH 2 Cl, -OCF 3 and -OCCl 3; - R 2 is selected from the group consisting of C 2-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 5-6 cycloalkenyl, -C(=O)-C 1-5 alkyl, -C(=O)-C 1-5 alkenyl, -C(=O)-C 1-5 alkynyl, -C(=O)-C 3-5 cycloalkyl and -C(=O)-C 5 cycloalkenyl, each of which may be optionally substituted with one or more, identical or different, substituents R 6; - R 3 is selected from the group consisting of hydrogen, deuterium, tritium, F, Cl, Br, I, -CN, -CF 3, -CCl 3, -CHF 2, -CHCl 2, -CH 2 F, -CH 2 Cl, -OCF 3, -OCCl 3 and isocyanide; - R 4 is selected from the group consisting of C 1-5 alkyl, C 1-5 alkenyl, C 1-5 alkynyl, C 3-5 cycloalkyl, C 5 cycloalkenyl, each of which may be optionally substituted with one or more, identical or different, substituents R 7; - R 5 is selected from the group consisting of H, C 1-5 alkyl optionally substituted with one or more, identical or different, substituents R 11, C 2-5 alkenyl, C 2-5 alkynyl, C 3-6 cycloalkyl optionally substituted with one or more, identical or different, substituents R 11, phenyl optionally substituted with one or more, identical or different, substituents R 12 and benzyl optionally substituted with one or more, identical or different, substituents R 12; - R 6 is independently selected from the group consisting of hydrogen, deuterium, tritium, F, Cl, Br, I, -CN, isocyanide, -O-C 1-3 alkyl, -S-C 1-3 alkyl, -CH 2 -OH, -CH 2 -O-C 1-3 alkyl, -O-CH 2 -Ph, -CH 2 -SH and -CH 2 -S-C 1-3 alkyl; - R 7 is independently selected from the group consisting of deuterium, tritium, F, Cl, Br, I, -CN, isocyanide, -O-C 1-3 alkyl, -S-C 1-3 alkyl, -CH 2 -O-C 1-3 alkyl and -CH 2 -S-C 1-3 alkyl; - R 11 is independently selected from the group consisting of deuterium and F; - R 12 is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I and F; and - n is an integer 0, 1, 2 or 3;