A wearable monitoring device for detecting a reaction of a cancerous tissue of an intrabody region comprising a tumor to an oncological therapy, comprising: at least one probe comprising at least one transducer configured for transmitting to and intercepting electromagnetic radiation from a cancerous tissue in an intrabody region of a patient; a processing unit configured for calculating a dielectric related change of the intrabody region by analyzing said intercepted EM radiation and for detecting a physiological pattern according to said dielectric related change; and an output unit configured for outputting a message indicating said physiological pattern; wherein said at least one probe and said processing unit are configured for performing said transmitting and intercepting and said analyzing in a plurality of EM radiation sessions during a period of at least 24 hours, characterized in that: said analyzing and detecting includes: to estimate, based on an anatomical reconstruction of the intrabody region and its surrounding tissue by an imaging modality, an expected signal of intercepted electromagnetic radiation by simulating changes of a physiological state of the tumor of the intrabody region, where these changes are estimated changes resulting from the oncological therapy of the tumor within said intrabody region, and to match said estimated signal to a detected signal of intercepted electromagnetic radiation, thereby detecting the physiological pattern. at least one probe comprising at least one transducer configured for transmitting to and intercepting electromagnetic radiation from a cancerous tissue in an intrabody region of a patient; a processing unit configured for calculating a dielectric related change of the intrabody region by analyzing said intercepted EM radiation and for detecting a physiological pattern according to said dielectric related change; and an output unit configured for outputting a message indicating said physiological pattern; wherein said at least one probe and said processing unit are configured for performing said transmitting and intercepting and said analyzing in a plurality of EM radiation sessions during a period of at least 24 hours, a processing unit configured for calculating a dielectric related change of the intrabody region by analyzing said intercepted EM radiation and for detecting a physiological pattern according to said dielectric related change; and an output unit configured for outputting a message indicating said physiological pattern; wherein said at least one probe and said processing unit are configured for performing said transmitting and intercepting and said analyzing in a plurality of EM radiation sessions during a period of at least 24 hours, said analyzing and detecting includes: to estimate, based on an anatomical reconstruction of the intrabody region and its surrounding tissue by an imaging modality, an expected signal of intercepted electromagnetic radiation by simulating changes of a physiological state of the tumor of the intrabody region, where these changes are estimated changes resulting from the oncological therapy of the tumor within said intrabody region, and to match said estimated signal to a detected signal of intercepted electromagnetic radiation, thereby detecting the physiological pattern. to estimate, based on an anatomical reconstruction of the intrabody region and its surrounding tissue by an imaging modality, an expected signal of intercepted electromagnetic radiation by simulating changes of a physiological state of the tumor of the intrabody region, where these changes are estimated changes resulting from the oncological therapy of the tumor within said intrabody region, and to match said estimated signal to a detected signal of intercepted electromagnetic radiation, thereby detecting the physiological pattern.