A compound represented by structural formula I: or a pharmaceutically acceptable salt of said compound, wherein B is -(CH 2) n3 -, -(CH 2)-O-, -(CH 2)S-, -(CH 2)-NR 6 -, -C NR 6 -. -NR 6 C -, -(CH 2) n4 CR 12 =CR 12a (CH 2) n5 - or -(CH 2) n4 C≡C(CH 2) n5 -, wherein n 3 is 0-5, n 4 and n 5 are independently 0-2, and R 12 and R 12a are independently selected from the group consisting of hydrogen, alkyl and halogen; Het is a mono-, bi- or tricyclic heteroaromatic group of 5 to 14 atoms comprised of 1 to 13 carbon atoms and 1 to 4 heteroatoms independently selected from the group consisting of N, O and S, with the proviso that there are no adjacent oxygen or sulfur atoms present in the heteroaromatic group, wherein a ring nitrogen can form an N-oxide or a quaternary group with an alkyl group, wherein Het is attached to B by a carbon atom ring member, and wherein the Het group is substituted by 1 to 4 moieties, W, wherein each W is independently selected from the group consisting of hydrogen; alkyl; fluoroalkyl; difluoroalkyl; trifluoroalkyl; cycloalkyl; heterocycloalkyl; heterocycloalkyl substituted by alkyl or alkenyl; alkenyl; R 21 -arylalkyl; R 21 -aryl-alkenyl; heteroaryl; heteroarylalkyl; heteroarylalkenyl; hydroxyalkyl; dihydroxyalkyl; aminoalkyl; alkylaminoalkyl; di-(alkyl)-aminoalkyl; thioalkyl; alkoxy; alkenyloxy; halogen; -NR 4 R 5; -CN; -OH; -C OR 17; -COR 16; -OS(O 2)CF 3; -CH 2 OCH 2 CF 3; alkylthio; -C NR 4 R 5; -OCHR 6 -phenyl; phenoxyalkyl; -NHCOR 16; -NHSO 2 R 16; biphenyl; -OC(R 6) 2 COOR 7; -OC(R 6) 2 C NR 4 R 5; alkoxy substituted by alkyl, amino or -NHC OR 17; aryl; aryl substituted by 1 to 3 substituents independently selected from the group consisting of alkyl, halogen, alkoxy, methylenedioxy, carboxylic acid, carboxamide, amine, urea, amide, sulfonamide, -CN, -CF 3, -OCF 3, -OH, alkylamino-, di-(alkyl)amino-, -NR 25 R 26 alkyl-, hydroxyalkyl-, -C OR 17, -COR 17, -NHCOR 16, -NHS 2 R 16, -NHS 2 CH 2 CF 3, -C NR 25 R 26, -NR 25 -C -NR 25 R 26, -S R 16, -S 2 R 16 and -SR 16; or alkyl optionally substituted with -NR 1 R 2, -NR 1 COR 2, -NR 1 CONR 1 R 2, -NR 1 C OR 2, -NR 1 S 2 R 2, -NR 1 S 2 NR 1 R 2, -C OH, -C OR 1, -CONR 1 R 2 heteroaryl, hydroxyalkyl, alkyl or -S 2 -alkyl;-C NR 4 R 5 or heteroaryl;wherein adjacent carbons on the Het ring can optionally form a ring with a methylenedioxy group; R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, difluoroalkyl, trifluoroalkyl, cycloalkyl, alkenyl, alkoxy, arylalkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl, hydroxy, hydroxyalkyl, alkoxyalkyl, aminoalkyl, aryl and thioalkyl; or R 1 and R 2 when attached to nitrogen, taken together, form a mono or bicyclic heterocyclic ring of 4 to 10 atoms, with 1-3 heteroatoms selected from -O-, -N-, -S-, -S -, -S 2 - and with the proviso that S and O ring atoms are not adjacent to each other, where said heterocyclic ring is unsubstituted or substituted with one or more groups selected from alkyl, halogen, hydroxy, alkoxy, aryloxy and arylalkoxy; R 6 is hydrogen, alkyl or phenyl; R 7 is hydrogen or alkyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, alkyl, phenyl, benzyl and cycloalkyl, or R 4 and R 5 together can form a ring with the nitrogen to which they are attached, wherein said ring formed by R 4 and R 5 is optionally substituted with =O, OH, OR 1 or -C OH; R 16 is independently selected from the group consisting of hydrogen, alkyl, phenyl and benzyl; R 17 is independently selected from the group consisting of hydrogen, alkyl, phenyl and benzyl; R 21 is 1 to 3 moieties and each R 21 is independently selected from the group consisting of hydrogen, -CN, -CF 3, -OCF 3, halogen, -NO 2, alkyl, -OH, alkoxy, alkylamino-, di-(alkyl)amino-, -NR 25 R 26 alkyl-, hydroxyalkyl-, -C OR 17, -COR 17, -NHCOR 16, -NHS 2 R 16, -C -NH 2, -NHS 2 CH 2 CF 3, -C NR 25 R 26, -NR 25 -C -NR 25 R 26, -S R 16, -S 2 R 16, -SR 16; -SO 2 NR 4 R 5 and -CONR 4 R 5; or two adjacent R 21 moieties can form a methylenedioxy group; R 25 and R 26 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, hydroxy and alkoxy; R 9 is hydrogen, OH, alkoxy, halogen or haloalkyl; R 10 and R 11 are independently selected from the group consisting of R 1, fluoroalkoxy, difluoroalkoxy, trifluoroalkoxy, cycloalkyloxy, alkenyloxy, arylalkoxy, arylalkenyloxy, heteroarylalkoxy, heteroarylalkenyloxy, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aryloxy and thioalkoxy, provided that when ring Q is aromatic and the carbon atoms bearing R 10 and R 11 are connected by a double bond, R 10 and R 11 are absent; alkyl is an aliphatic hydrocarbon group which is straight or branched, comprising 1 to 20 carbon atoms in the chain; alkenyl is an aliphatic hydrocarbon group which is straight or branched, comprising one or more double bonds in the chain and 2 to 15 carbon atoms in the chain; aryl is an aromatic monocyclic or multicyclic ring system, comprising 6 to 14 carbon atoms; heteroaryl is an aromatic monocyclic or multicyclic ring system, comprising 5 to 14 ring atoms, in which one or more ring atoms is nitrogen, oxygen or sulfur, alone or in combination, providing that the rings do not include adjacent oxygen and/or sulfur atoms; and heterocyclyl is a non-aromatic saturated monocyclic or multicyclic ring system, comprising 3 to 10 ring atoms, in which one or more ring atoms is nitrogen, oxygen or sulfur, alone or in combination; and pharmaceutically acceptable salts thereof.