An article of footwear comprising: an upper; and a midsole positioned beneath the upper and comprising: an upper portion formed of a first material; and a lower portion formed of a second material, positioned beneath the upper portion; and comprising: a plurality of support members spaced from adjacent support members and defining gaps between adjacent support members that extend completely through the lower portion, with each gap being spaced from a periphery of the lower portion and completely surrounded by a peripheral wall formed of the second material; and a plurality of connecting members extending between and connected to adjacent support members, the connecting members having a height that is less than a height of the support members to which the connecting members are connected, and an upper surface that is substantially flush with an upper surface of the support members to which the connecting members are connected. an upper; and a midsole positioned beneath the upper and comprising: an upper portion formed of a first material; and a lower portion formed of a second material, positioned beneath the upper portion; and comprising: a plurality of support members spaced from adjacent support members and defining gaps between adjacent support members that extend completely through the lower portion, with each gap being spaced from a periphery of the lower portion and completely surrounded by a peripheral wall formed of the second material; and a plurality of connecting members extending between and connected to adjacent support members, the connecting members having a height that is less than a height of the support members to which the connecting members are connected, and an upper surface that is substantially flush with an upper surface of the support members to which the connecting members are connected. an upper portion formed of a first material; and a lower portion formed of a second material, positioned beneath the upper portion; and comprising: a plurality of support members spaced from adjacent support members and defining gaps between adjacent support members that extend completely through the lower portion, with each gap being spaced from a periphery of the lower portion and completely surrounded by a peripheral wall formed of the second material; and a plurality of connecting members extending between and connected to adjacent support members, the connecting members having a height that is less than a height of the support members to which the connecting members are connected, and an upper surface that is substantially flush with an upper surface of the support members to which the connecting members are connected. a plurality of support members spaced from adjacent support members and defining gaps between adjacent support members that extend completely through the lower portion, with each gap being spaced from a periphery of the lower portion and completely surrounded by a peripheral wall formed of the second material; and a plurality of connecting members extending between and connected to adjacent support members, the connecting members having a height that is less than a height of the support members to which the connecting members are connected, and an upper surface that is substantially flush with an upper surface of the support members to which the connecting members are connected.