A catheter delivery system comprising: a catheter sheath (104; 200; 400) having a steerable distal portion (204; 404), the catheter sheath having a plurality of steering lines (118A-D; 220, 222, 224, 226; 420, 422, 424, 426) running through a plurality of peripheral lumens (230, 234, 238, 242; 430, 434, 438, 442) of a first flexible elongate member (212; 402) having a central lumen (246; 410), the distal end of each steering line being connected to a steering ring in the steerable distal portion of the catheter sheath and the proximal end of each steering line being connected to an attachment site of a steering actuator coupled to a housing sized and shaped for handheld use, wherein the housing includes an opening extending therethrough in communication with the central lumen of the first flexible elongate member to allow the insertion of intravascular devices of different modalities into the central lumen of the first flexible elongate member and removal of the intravascular devices of different modalities from the central lumen of the first flexible elongate member, and wherein the housing further comprises an alignment tube and a steering line guide; wherein the alignment tube is coupled to the opening; wherein the steering line guide is coupled to the catheter sheath (104; 200; 400) and such that the attachment sites of the steering actuator are disposed between the alignment tube and the steering line guide; wherein the steering line guide comprises a conical portion configured to guide both i) each steering line (118A-D; 220, 222, 224, 226; 420, 422, 424, 426) between its steering actuator attachment site and its corresponding peripheral lumen (230, 234, 238, 242; 430, 434, 438, 442), and ii) the intravascular device between the alignment tube and the central lumen (246; 410). a catheter sheath (104; 200; 400) having a steerable distal portion (204; 404), the catheter sheath having a plurality of steering lines (118A-D; 220, 222, 224, 226; 420, 422, 424, 426) running through a plurality of peripheral lumens (230, 234, 238, 242; 430, 434, 438, 442) of a first flexible elongate member (212; 402) having a central lumen (246; 410), the distal end of each steering line being connected to a steering ring in the steerable distal portion of the catheter sheath and the proximal end of each steering line being connected to an attachment site of a steering actuator coupled to a housing sized and shaped for handheld use, wherein the housing includes an opening extending therethrough in communication with the central lumen of the first flexible elongate member to allow the insertion of intravascular devices of different modalities into the central lumen of the first flexible elongate member and removal of the intravascular devices of different modalities from the central lumen of the first flexible elongate member, and wherein the housing further comprises an alignment tube and a steering line guide; wherein the alignment tube is coupled to the opening; wherein the steering line guide is coupled to the catheter sheath (104; 200; 400) and such that the attachment sites of the steering actuator are disposed between the alignment tube and the steering line guide; wherein the steering line guide comprises a conical portion configured to guide both i) each steering line (118A-D; 220, 222, 224, 226; 420, 422, 424, 426) between its steering actuator attachment site and its corresponding peripheral lumen (230, 234, 238, 242; 430, 434, 438, 442), and ii) the intravascular device between the alignment tube and the central lumen (246; 410).