A device for targeted delivery of a therapeutic agent, comprising: an elongated catheter body comprising an inflation lumen and at least one therapeutic agent delivery lumen; a first inner sheet and a second inner sheet, wherein the first inner sheet and the second inner sheet comprise a water impermeable material; and, wherein the first inner sheet comprises a first inner seam and the second inner sheet comprises a second inner seam, wherein the first inner sheet and the second inner sheet are sealed to one another at the first inner seam and the second inner seam, and wherein the first inner sheet and the second inner sheet defining an inflation chamber in a volume between the first and second inner sheets; a first outer sheet and a second outer sheet; sheet; wherein the first outer sheet comprises a first outer seam and the second outer sheet comprises a second outer seam, wherein the first outer sheet and the second outer sheet are sealed to one another at the first outer seam and the second outer seam, and wherein at least one of the outer seams incorporate at least one of the first inner seam and the second inner seam; a first delivery chamber (28,28a) comprising a volume between an outer surface of at least one of the first and second inner sheets and an inner surface of at least one of the first and second outer sheets; wherein the inner sheets are bonded to the elongate catheter body such that the inflation lumen is in fluid communication with the inflation chamber; wherein the outer sheets are bonded to the elongated catheter body such that the at least one therapeutic agent delivery lumen is joined in fluid communication with the at least one therapeutic agent delivery chamber; and wherein the therapeutic agent delivery chamber is not in fluid communication with the inflation chamber. an elongated catheter body comprising an inflation lumen and at least one therapeutic agent delivery lumen; a first inner sheet and a second inner sheet, wherein the first inner sheet and the second inner sheet comprise a water impermeable material; and, wherein the first inner sheet comprises a first inner seam and the second inner sheet comprises a second inner seam, wherein the first inner sheet and the second inner sheet are sealed to one another at the first inner seam and the second inner seam, and wherein the first inner sheet and the second inner sheet defining an inflation chamber in a volume between the first and second inner sheets; a first outer sheet and a second outer sheet; sheet; wherein the first outer sheet comprises a first outer seam and the second outer sheet comprises a second outer seam, wherein the first outer sheet and the second outer sheet are sealed to one another at the first outer seam and the second outer seam, and wherein at least one of the outer seams incorporate at least one of the first inner seam and the second inner seam; a first delivery chamber (28,28a) comprising a volume between an outer surface of at least one of the first and second inner sheets and an inner surface of at least one of the first and second outer sheets; wherein the inner sheets are bonded to the elongate catheter body such that the inflation lumen is in fluid communication with the inflation chamber; wherein the outer sheets are bonded to the elongated catheter body such that the at least one therapeutic agent delivery lumen is joined in fluid communication with the at least one therapeutic agent delivery chamber; and wherein the therapeutic agent delivery chamber is not in fluid communication with the inflation chamber.