mhurhangee/ep-ind-claims huggingface dataset:
A composite airfoil, comprising: a first ply (300, 350, 401a) having a first plurality of strips of fiber (320, 370) oriented at a first angle with respect to a longitudinal axis (302, 352) and a second plurality of strips of fiber (322, 372) oriented at a second angle with respect to the longitudinal axis characterised in that at least one strip of the first plurality of strips of fiber (320, 370) intersects at least one strip of the second plurality of strips of fiber (322, 372) at a common intersection line (334, 338, 384, 388) within the first ply (300, 350, 401a) without a gap or a space between the at least one strip of the first plurality of strips of fiber and the at least one strip of the second plurality of strips of fiber and at least a first subset of the first plurality of strips of fiber has fibers intersecting and oriented perpendicular to the fibers of at least a second subset of the second plurality of strips of fiber within the first ply. a first ply (300, 350, 401a) having a first plurality of strips of fiber (320, 370) oriented at a first angle with respect to a longitudinal axis (302, 352) and a second plurality of strips of fiber (322, 372) oriented at a second angle with respect to the longitudinal axis characterised in that at least one strip of the first plurality of strips of fiber (320, 370) intersects at least one strip of the second plurality of strips of fiber (322, 372) at a common intersection line (334, 338, 384, 388) within the first ply (300, 350, 401a) without a gap or a space between the at least one strip of the first plurality of strips of fiber and the at least one strip of the second plurality of strips of fiber and at least a first subset of the first plurality of strips of fiber has fibers intersecting and oriented perpendicular to the fibers of at least a second subset of the second plurality of strips of fiber within the first ply.
Self-disinfecting drain trap for drainage pipes having a drain trap body, at least one light source (4, 18), and devices for automatic disinfection and cleaning during use and without an interruption of the barrier function, wherein the device for cleaning the drain trap body is at least one electromechanical vibrator and the device(s) for disinfection of the drain trap body are at least one antibacterial coating and, optionally, a device selected from the group comprising heating elements, UV-C emitters, and ultrasonic vibrators, and wherein the at least one light source (4, 18) is arranged inside of or outside of the drain trap body, characterized in that the drain trap body is provided on the inside with a titanium dioxide nano-coating, which forms the antibacterial coating and which is activated by the light source (4, 18) located inside of or outside of the drain trap body.
An article of footwear comprising: an upper, the upper connected to a fastening region, wherein the upper includes an opening, and wherein at least a portion of the opening is adjustable by a fastening system; a sole attached to the upper; and a tendon assembly secured to the upper between the sole and the fastening region, the tendon assembly having a longitudinal direction directed along the length of the tendon assembly and a lateral direction perpendicular to the longitudinal direction, wherein the tendon assembly comprises: a base layer; a separate top layer connected to the base layer; and a tendon positioned between the base layer and the top layer, characterized in that the tendon moves freely between the base layer and the top layer in both the longitudinal direction and the lateral direction; and that the tendon is configured to move with the fastening system. an upper, the upper connected to a fastening region, wherein the upper includes an opening, and wherein at least a portion of the opening is adjustable by a fastening system; a sole attached to the upper; and a tendon assembly secured to the upper between the sole and the fastening region, the tendon assembly having a longitudinal direction directed along the length of the tendon assembly and a lateral direction perpendicular to the longitudinal direction, wherein the tendon assembly comprises: a base layer; a separate top layer connected to the base layer; and a tendon positioned between the base layer and the top layer, a base layer; a separate top layer connected to the base layer; and a tendon positioned between the base layer and the top layer, characterized in that the tendon moves freely between the base layer and the top layer in both the longitudinal direction and the lateral direction; and that the tendon is configured to move with the fastening system.
An emergency lighting system (100, 200), comprising: a DC bus, at least one emergency lighting means (101a, 101b) connected to the DC bus, a central unit (103, 201) connected to the DC bus, wherein the central unit (103, 201) is configured to supply the at least one emergency lighting means (101a, 101b) with a bus voltage via the DC bus, and an operating device for communicating with the central unit (103, 201), wherein the operating device is configured to display a graphical user interface, wherein the operating device is configured to receive a user input on the graphical user interface, and wherein the central unit (103, 201) comprises a powerline modulation unit for modulating the bus voltage, wherein the central unit (103, 201) is configured to commission and/or to configure the at least one emergency lighting means (101a, 101b) based on the user input via powerline modulation of the bus voltage, characterized in that the central unit (103, 201) in a non-emergency mode is configured to periodically transmit a status signal to the at least one emergency lighting means (101a, 101b) on the DC bus, in particular by means of a powerline modulation of the bus voltage, and the at least one emergency lighting means (101a, 101b), in particular a LED-driver or converter (503-1...n), is configured to receive the status signal, wherein the at least one emergency lighting means (101a, 101b) is configured to detect an emergency situation if the status signal is not received within a certain reference time span. a DC bus, at least one emergency lighting means (101a, 101b) connected to the DC bus, a central unit (103, 201) connected to the DC bus, wherein the central unit (103, 201) is configured to supply the at least one emergency lighting means (101a, 101b) with a bus voltage via the DC bus, and an operating device for communicating with the central unit (103, 201), wherein the operating device is configured to display a graphical user interface, wherein the operating device is configured to receive a user input on the graphical user interface, and wherein the central unit (103, 201) comprises a powerline modulation unit for modulating the bus voltage, wherein the central unit (103, 201) is configured to commission and/or to configure the at least one emergency lighting means (101a, 101b) based on the user input via powerline modulation of the bus voltage, characterized in that the central unit (103, 201) in a non-emergency mode is configured to periodically transmit a status signal to the at least one emergency lighting means (101a, 101b) on the DC bus, in particular by means of a powerline modulation of the bus voltage, and the at least one emergency lighting means (101a, 101b), in particular a LED-driver or converter (503-1...n), is configured to receive the status signal, wherein the at least one emergency lighting means (101a, 101b) is configured to detect an emergency situation if the status signal is not received within a certain reference time span.
A thieno[3,2-d]pyrimidine derivative of formula: wherein, A is C 6-10 aryl or 5- to 10-membered heteroaryl; W is O, S, S, S 2, NH, -NHNH- or 3- to 6-membered heterocycloalkyl; X and Y are each independently CH or N; Z is hydrogen, C 1-3 alkyl or NR 3 R 4, wherein said R 3 and R 4 are each independently hydrogen, C 1-6 alkyl or -(CH 2)q-B, B representing NR 5 R 6, C 1-6 alkoxy, C 3-6 cycloalkyl or 3-to 6-membered heterocycloalkyl; R 1 is hydrogen, halogen, C 1-3 alkyl or C 1-3 alkoxy, wherein said alkyl or alkoxy is unsubstituted or substituted with one or more halogen atoms; R 2 is hydrogen, halogen, -CF 3, -NO 2, -OH, -CN, C 1-6 alkoxy, C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, -NR 7 R 8, -NHSO 2 R 9, -SO 2 R 10, -C R 11, -NHC R 12, -NHC OR 13,-S R 14, C 3-6 cycloalkyl, 5- to 10-membered heterocycloalkyl, C 6-10 aryl, C 6-10 aryloxy, 5-to 10-membered heteroaryl or 3- to 6-membered heteroaryloxy, wherein said R 2 is connected to A by -(CH 2)p- or substituted with C 1-4 alkyl, C 2-4 alkynyl, C 1-4 alkylcarbonyl or one or more halogen atoms; R 5, R 6, R 7, R 8, R 9, R 10, R 11, R 12, R 13 and R 14 are each independently hydrogen, -NH 2, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl or 3-to 6-membered heterocycloalkyl, said alkyl, alkoxy, cycloalkyl or heterocycloalkyl being unsubstituted or substituted with one or more halogen atoms; q is an integer ranging from 0 to 3; p is an integer ranging from 0 to 3; m is an integer ranging from 0 to 5; n is an integer ranging from 0 to 2; or a pharmaceutically acceptable salt thereof. A is C 6-10 aryl or 5- to 10-membered heteroaryl; W is O, S, S, S 2, NH, -NHNH- or 3- to 6-membered heterocycloalkyl; X and Y are each independently CH or N; Z is hydrogen, C 1-3 alkyl or NR 3 R 4, wherein said R 3 and R 4 are each independently hydrogen, C 1-6 alkyl or -(CH 2)q-B, B representing NR 5 R 6, C 1-6 alkoxy, C 3-6 cycloalkyl or 3-to 6-membered heterocycloalkyl; R 1 is hydrogen, halogen, C 1-3 alkyl or C 1-3 alkoxy, wherein said alkyl or alkoxy is unsubstituted or substituted with one or more halogen atoms; R 2 is hydrogen, halogen, -CF 3, -NO 2, -OH, -CN, C 1-6 alkoxy, C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, -NR 7 R 8, -NHSO 2 R 9, -SO 2 R 10, -C R 11, -NHC R 12, -NHC OR 13,-S R 14, C 3-6 cycloalkyl, 5- to 10-membered heterocycloalkyl, C 6-10 aryl, C 6-10 aryloxy, 5-to 10-membered heteroaryl or 3- to 6-membered heteroaryloxy, wherein said R 2 is connected to A by -(CH 2)p- or substituted with C 1-4 alkyl, C 2-4 alkynyl, C 1-4 alkylcarbonyl or one or more halogen atoms; R 5, R 6, R 7, R 8, R 9, R 10, R 11, R 12, R 13 and R 14 are each independently hydrogen, -NH 2, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl or 3-to 6-membered heterocycloalkyl, said alkyl, alkoxy, cycloalkyl or heterocycloalkyl being unsubstituted or substituted with one or more halogen atoms; q is an integer ranging from 0 to 3; p is an integer ranging from 0 to 3; m is an integer ranging from 0 to 5; n is an integer ranging from 0 to 2;
Process for depleting fibrinogen solutions of fibrinogen-degrading proteases and/or proenzymes, wherein it comprises one or more process steps in which one or more contaminating, fibrinogen-degrading proteases and/or proenzymes are depleted by one or more negative chromatographies and/or one or more negative adsorptions using cation exchangers, wherein human plasma, a plasma-fraction or cryoprecipitate is used as starting material for preparing the fibrinogen solution, wherein the negative chromatography and/or the negative adsorption is carried out at a pH between 5.5 and 9, and wherein the mobile phase has a pH and an ionic strength at which no or only slight interactions occur between the fibrinogen and the negatively charged groups of the stationary phase, whereas interactions still occur between the stationary phase and the one or more contaminating proteins, and wherein, in the negative chromatography and/or negative adsorption, only a relatively small proportion or none of the fibrinogen binds to the chromatography column, and wherein the yield of fibrinogen in the flow-through of the negative chromatography or in the supernatant of the negative adsorption is ≥ 50%, and wherein sulphomethyl groups (S types), sulphopropyl groups (SP types), carboxymethyl groups (CM types) are used as functional group of the cation exchanger.
A method of detection of a protease enzyme in a sample, comprising the steps of: (i) exposing the sample to a polypeptide comprising a chromogenic amino acid, wherein the chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof, the amine group of the chromogenic amino acid has a pKa of less than 5 and the chromogenic amino acid is capable of reacting with a conjugated aldehyde, and wherein the polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid; and allowing the protease to cleave the polypeptide and create a fragment displaying the chromogenic amino acid to the N-terminus of the fragment; (ii) reacting a conjugated aldehyde with the fragment comprising the chromogenic amino acid to produce a coloured adduct; and (iii) detecting the coloured adduct, the presence of the coloured adduct being indicative of the presence of the protease enzyme in the sample. (i) exposing the sample to a polypeptide comprising a chromogenic amino acid, wherein the chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof, the amine group of the chromogenic amino acid has a pKa of less than 5 and the chromogenic amino acid is capable of reacting with a conjugated aldehyde, and wherein the polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid; and allowing the protease to cleave the polypeptide and create a fragment displaying the chromogenic amino acid to the N-terminus of the fragment; (ii) reacting a conjugated aldehyde with the fragment comprising the chromogenic amino acid to produce a coloured adduct; and (iii) detecting the coloured adduct, the presence of the coloured adduct being indicative of the presence of the protease enzyme in the sample.
A system, comprising: a trim having a plurality of flow paths, wherein each flow path comprises: a series of stages (108, 122, 124, 126, 128, 130, 132); and an expansion zone (110, 112, 114, 116, 118, 120) disposed in series between each of the stages (108, 122, 124, 126, 128, 130, 132), wherein the expansion zones (110, 112, 114, 116, 118, 120) are configured to flow a fluid in a direction that is generally transverse to directions of flow in both an adjacent-upstream stage (108, 122, 124, 126, 128, 130, 132) and an adjacent-downstream stage (108, 122, 124, 126, 128, 130, 132); wherein the stages (108, 122, 124, 126, 128, 130, 132) progressively increase in size along each of the flow paths according to an expansion ratio, characterised in that the expansion ratio increases along each of the flow paths. a trim having a plurality of flow paths, wherein each flow path comprises: a series of stages (108, 122, 124, 126, 128, 130, 132); and an expansion zone (110, 112, 114, 116, 118, 120) disposed in series between each of the stages (108, 122, 124, 126, 128, 130, 132), wherein the expansion zones (110, 112, 114, 116, 118, 120) are configured to flow a fluid in a direction that is generally transverse to directions of flow in both an adjacent-upstream stage (108, 122, 124, 126, 128, 130, 132) and an adjacent-downstream stage (108, 122, 124, 126, 128, 130, 132); a series of stages (108, 122, 124, 126, 128, 130, 132); and an expansion zone (110, 112, 114, 116, 118, 120) disposed in series between each of the stages (108, 122, 124, 126, 128, 130, 132), wherein the expansion zones (110, 112, 114, 116, 118, 120) are configured to flow a fluid in a direction that is generally transverse to directions of flow in both an adjacent-upstream stage (108, 122, 124, 126, 128, 130, 132) and an adjacent-downstream stage (108, 122, 124, 126, 128, 130, 132); wherein the stages (108, 122, 124, 126, 128, 130, 132) progressively increase in size along each of the flow paths according to an expansion ratio, characterised in that the expansion ratio increases along each of the flow paths.
A light-emitting diode (1, 2, 3) having a base and an LED chip placed on the base, comprising a first sealing material layer (12, 20) covering the LED chip and a second sealing material layer (13, 21) surrounding a side surface of the first sealing material layer, wherein the first sealing material layer (12, 20) has a cylinder shape, the first sealing material layer (12, 20) surrounds a side surface of the LED chip, an upper surface of the first sealing material layer (12, 20) and an upper surface of the second sealing material layer (13, 21) form an identical plane that is a vertically terminating light-output plane including all of the upper surfaces of the first and second sealing material layers of the light-emitting diode, a refractive index of the first sealing material layer (12, 20) is different from that of the second sealing material layer (13, 21), characterized in that the second sealing material layer (13, 21) has a cylinder shape including the first sealing material layer, and in that a side surface of the second sealing material layer (13, 21) is exposed. a first sealing material layer (12, 20) covering the LED chip and a second sealing material layer (13, 21) surrounding a side surface of the first sealing material layer, wherein the first sealing material layer (12, 20) has a cylinder shape, the first sealing material layer (12, 20) surrounds a side surface of the LED chip, an upper surface of the first sealing material layer (12, 20) and an upper surface of the second sealing material layer (13, 21) form an identical plane that is a vertically terminating light-output plane including all of the upper surfaces of the first and second sealing material layers of the light-emitting diode, a refractive index of the first sealing material layer (12, 20) is different from that of the second sealing material layer (13, 21), characterized in that the second sealing material layer (13, 21) has a cylinder shape including the first sealing material layer, and in that a side surface of the second sealing material layer (13, 21) is exposed.
A weapon system for use on a vehicle, the weapon system comprising: a control system configured to, in response to a determination that a line-of-sight from the weapon system to a target of the weapon system is currently, or going to be obscured, trigger an alteration of a configuration of the vehicle such that the line-of-sight to the target is not obscured, characterised in that the weapon system further comprises: a directed-energy weapon configured to output an energy beam at the target; wherein the directed-energy weapon comprises two or more apertures for outputting an energy beam; and wherein the control system is further configured to control the directed-energy weapon to employ one of the apertures, based on a probability of successfully engaging the target. characterised in that the weapon system further comprises: a directed-energy weapon configured to output an energy beam at the target; wherein the directed-energy weapon comprises two or more apertures for outputting an energy beam; and wherein the control system is further configured to control the directed-energy weapon to employ one of the apertures, based on a probability of successfully engaging the target.
A system comprising: a pulse generator configured to generate a stimulation signal (32, 34, 36, 38) for application to neural tissue of an individual, wherein the stimulation signal (32, 34, 36, 38) comprises a time-varying pattern of pulses; an electrode coupled to the pulse generator and configured to apply the stimulation signal (32, 34, 36, 38) to the neural tissue, a receiver to receive a feedback signal in response to application of the stimulation signal (32, 34, 36, 38) to the neural tissue, characterized in that the pulse generator is configured to modulate a parameter related to intensity of the time-varying pattern of pulses of the stimulation signal with time (32, 34, 36, 38) to recruit a different population of axons with each pulse of the stimulation signal based on the feedback signal. a pulse generator configured to generate a stimulation signal (32, 34, 36, 38) for application to neural tissue of an individual, wherein the stimulation signal (32, 34, 36, 38) comprises a time-varying pattern of pulses; an electrode coupled to the pulse generator and configured to apply the stimulation signal (32, 34, 36, 38) to the neural tissue, a receiver to receive a feedback signal in response to application of the stimulation signal (32, 34, 36, 38) to the neural tissue,
Device for separating a bodily fluid into fractions under centrifugal force, which device comprises a centrifuge and a flexible container system, the container system comprising at least a first container for the fluid to be separated and a second container for a separated fraction, wherein the containers (2, 4) are mutually connected using a connecting conduit for a fluid, wherein a widened portion is arranged in the connecting conduit between the first and second container, and wherein during centrifugation a detectable separating layer is created in the widened portion, characterized in that the device further comprises a row of detection means arranged in the direction of flow of the bodily fluid along the whole or partial length direction of the widened portion for detecting the position and the progress of the separated fractions in the widened portion, and in particular of the separating layer, the device further comprising means allowing precise adjustment of the rotation speed of the centrifuge subject to the measured position of the separating layer.