A heat transfer composition comprising: (a) from about 10% to about 35% by weight of HFC-32; (b) from about 10% to about 35% by weight of HFC-125; (c) from about 20% to about 50% by weight of HFO-1234ze, HFO-1234yf and combinations of these; (d) from about 15% to about 35% by weight of HFC-134a, with the weight percent being based on the total of the components (a) - (d) in the composition, with the proviso that said heat transfer composition is not one of the following compositions: a) a composition containing 35% by weight HFO-1234yf, 25% by weight HFC-134a, 30% by weight HFC-125 and 10% by weight HFC-32; b) a composition containing 50% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 10% by weight HFC-32; c) a composition containing 40% by weight HFO-1234yf, 25% by weight HFC-134a, 25% by weight HFC-125 and 10% by weight HFC-32; d) a composition containing 40% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 20% by weight HFC-32; e) a composition containing 30% by weight HFO-1234yf, 25% by weight HFC-134a, 25% by weight HFC-125 and 20% by weight HFC-32; f) a composition containing 25% by weight HFO-1234yf, 30% by weight HFC-134a, 25% by weight HFC-125 and 20% by weight HFC-32; g) a composition containing 25% by weight HFO-1234yf, 25% by weight HFC-134a, 30% by weight HFC-125 and 20% by weight HFC-32; h) a composition containing 40% by weight HFO-1234yf, 15% by weight HFC-134a, 15% by weight HFC-125 and 30% by weight HFC-32; i) a composition containing 30% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 30% by weight HFC-32; j) a composition containing 20% by weight HFO-1234yf, 30% by weight HFC-134a, 20% by weight HFC-125 and 30% by weight HFC-32; and k) a composition containing 20% by weight HFO-1234yf, 20% by weight HFC-134a, 30% by weight HFC-125 and 30% by weight HFC-32. a) a composition containing 35% by weight HFO-1234yf, 25% by weight HFC-134a, 30% by weight HFC-125 and 10% by weight HFC-32; b) a composition containing 50% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 10% by weight HFC-32; c) a composition containing 40% by weight HFO-1234yf, 25% by weight HFC-134a, 25% by weight HFC-125 and 10% by weight HFC-32; d) a composition containing 40% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 20% by weight HFC-32; e) a composition containing 30% by weight HFO-1234yf, 25% by weight HFC-134a, 25% by weight HFC-125 and 20% by weight HFC-32; f) a composition containing 25% by weight HFO-1234yf, 30% by weight HFC-134a, 25% by weight HFC-125 and 20% by weight HFC-32; g) a composition containing 25% by weight HFO-1234yf, 25% by weight HFC-134a, 30% by weight HFC-125 and 20% by weight HFC-32; h) a composition containing 40% by weight HFO-1234yf, 15% by weight HFC-134a, 15% by weight HFC-125 and 30% by weight HFC-32; i) a composition containing 30% by weight HFO-1234yf, 20% by weight HFC-134a, 20% by weight HFC-125 and 30% by weight HFC-32; j) a composition containing 20% by weight HFO-1234yf, 30% by weight HFC-134a, 20% by weight HFC-125 and 30% by weight HFC-32; and k) a composition containing 20% by weight HFO-1234yf, 20% by weight HFC-134a, 30% by weight HFC-125 and 30% by weight HFC-32.