A non-invasive device for promoting a localized change in a flow of blood through a blood vessel in a lower leg, the device comprising: (a) a plurality of electrodes (20a, 20b, 20c, 20d) including at least a first electrode, a second electrode, a third electrode, and a fourth electrode each of said electrodes (20a, 20b, 20c, 20d) for operatively contacting the lower leg; (b) a signal generator, operatively connected to each of said electrodes (20a, 20b, 20c, 20d), for providing a series of electrical impulses to the lower leg via said plurality of electrodes (20a, 20b, 20c, 20d), said signal generator configured for connecting to a power supply; (c) a control unit, associated with said signal generator, for controlling said signal generator so as to produce said series of electrical stimulation impulses, said impulses being of pre-determined voltage differential, form, and duration, and (d) a switching mechanism designed and configured for switching electrical connections between said signal generator and each of said electrodes (20a, 20b, 20c, 20d), according to a pre-determined sequence, so as to provide a first voltage differential between said first electrode and said second electrode, a second voltage differential between said second electrode and said third electrode following the first voltage differential, and a third voltage differential between said third electrode and the fourth electrode of said plurality of electrodes (20a, 20b, 20c, 20d) following the second voltage differential, characterised in that said control unit and said switching mechanism are configured such that a frequency of said series of electrical stimulation impulses delivered to the electrodes (20a, 20b, 20c, 20d) is 5-20 periods per minute, a period being a repeating sequence of the first, second and third voltage differential between the at least four electrodes (20a, 20b, 20c, 20d), wherein said control unit is designed and configured such that when said electrodes (20a, 20b, 20c, 20d) operatively contact the lower leg, with the first and second electrodes (20a, 20b) being affixed at an upper end of the lower leg and the third and fourth electrodes (20c, 20d) being affixed at the opposite end of the lower leg, said first, second and third voltage differentials induce at least one substantially radial contraction of a first portion of the muscular tissue in the lower leg, at least partially followed by a substantially longitudinal contraction of a second portion of the muscular tissue in the lower leg within one period, so as to effect the localized change in the flow of blood through the blood vessel. (a) a plurality of electrodes (20a, 20b, 20c, 20d) including at least a first electrode, a second electrode, a third electrode, and a fourth electrode each of said electrodes (20a, 20b, 20c, 20d) for operatively contacting the lower leg; (b) a signal generator, operatively connected to each of said electrodes (20a, 20b, 20c, 20d), for providing a series of electrical impulses to the lower leg via said plurality of electrodes (20a, 20b, 20c, 20d), said signal generator configured for connecting to a power supply; (c) a control unit, associated with said signal generator, for controlling said signal generator so as to produce said series of electrical stimulation impulses, said impulses being of pre-determined voltage differential, form, and duration, and (d) a switching mechanism designed and configured for switching electrical connections between said signal generator and each of said electrodes (20a, 20b, 20c, 20d), according to a pre-determined sequence, so as to provide a first voltage differential between said first electrode and said second electrode, a second voltage differential between said second electrode and said third electrode following the first voltage differential, and a third voltage differential between said third electrode and the fourth electrode of said plurality of electrodes (20a, 20b, 20c, 20d) following the second voltage differential,