A tissue-removing catheter for removing tissue in a body lumen, the tissue-removing catheter comprising: an elongate body having an axis and proximal and distal end portions (16, 18) spaced apart from one another along the axis, the elongate body being sized and shaped to be received in the body lumen; a tissue-removing element mounted on the distal end portion of the elongate body, the tissue-removing element comprising a body including an exterior surface having a first segment extending from a proximal end toward a distal end of the tissue-removing element, a second segment extending from the first segment toward the distal end of the tissue-removing element, and a third segment extending from the second segment to the distal end of the tissue-removing element, a transition between the first and second segments (80, 82) defining a first angle (α) formed between the first and second segments (80, 82), and a transition between the second and third segments (82, 84) defining a second angle (β) formed between the second and third segments (82, 84), the tissue-removing element being configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen; a cavity extending through the body of the tissue-removing element from the proximal end to the distal end; characterized in that the cavity includes a first section extending distally from the proximal end of the tissue-removing element and a second section extending proximally from the distal end of the tissue-removing element, the first section having a larger cross-sectional dimension than a cross-sectional dimension of the second section; and wherein the second section is sized to pass an inner liner with a small clearance. an elongate body having an axis and proximal and distal end portions (16, 18) spaced apart from one another along the axis, the elongate body being sized and shaped to be received in the body lumen; a tissue-removing element mounted on the distal end portion of the elongate body, the tissue-removing element comprising a body including an exterior surface having a first segment extending from a proximal end toward a distal end of the tissue-removing element, a second segment extending from the first segment toward the distal end of the tissue-removing element, and a third segment extending from the second segment to the distal end of the tissue-removing element, a transition between the first and second segments (80, 82) defining a first angle (α) formed between the first and second segments (80, 82), and a transition between the second and third segments (82, 84) defining a second angle (β) formed between the second and third segments (82, 84), the tissue-removing element being configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen; a cavity extending through the body of the tissue-removing element from the proximal end to the distal end; characterized in that the cavity includes a first section extending distally from the proximal end of the tissue-removing element and a second section extending proximally from the distal end of the tissue-removing element, the first section having a larger cross-sectional dimension than a cross-sectional dimension of the second section; and wherein the second section is sized to pass an inner liner with a small clearance.