mhurhangee/ep-ind-claims huggingface dataset:
A combined preparation, which comprises: (a) a derivative of LAG-3 protein that is able to bind to MHC class II molecules; wherein the derivative of LAG-3 protein comprises: the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein; or a variant of the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein, wherein the variant comprises one or more conservative amino acid substitutions, and has at least 70% amino acid identity with the 30 amino acid extra-loop sequence; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, wherein the PD-1 pathway inhibitor inhibits binding of PD-1 to PD-L1 and/or PD-L2, and wherein: the PD-1 pathway inhibitor comprises an anti-PD-1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-1 to PD-L1 and/or PD-L2; or the PD-1 pathway inhibitor comprises an anti-PD-L1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-L1 to PD-1. (a) a derivative of LAG-3 protein that is able to bind to MHC class II molecules; wherein the derivative of LAG-3 protein comprises: the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein; or a variant of the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein, wherein the variant comprises one or more conservative amino acid substitutions, and has at least 70% amino acid identity with the 30 amino acid extra-loop sequence; and the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein; or a variant of the 30 amino acid extra-loop sequence GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY (SEQ ID NO:2) of domain D1 of human LAG-3 protein, wherein the variant comprises one or more conservative amino acid substitutions, and has at least 70% amino acid identity with the 30 amino acid extra-loop sequence; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, wherein the PD-1 pathway inhibitor inhibits binding of PD-1 to PD-L1 and/or PD-L2, and wherein: the PD-1 pathway inhibitor comprises an anti-PD-1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-1 to PD-L1 and/or PD-L2; or the PD-1 pathway inhibitor comprises an anti-PD-L1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-L1 to PD-1. the PD-1 pathway inhibitor comprises an anti-PD-1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-1 to PD-L1 and/or PD-L2; or the PD-1 pathway inhibitor comprises an anti-PD-L1 antibody, or a derivative or fragment thereof that retains ability to inhibit binding of PD-L1 to PD-1.
An in vitro method of screening for a compound useful in the treatment of multiple sclerosis, said method comprising: (i) providing a glial cell; (ii) staining at least one vesicle of said glial cell; (iii) contacting said glial cell with a test compound; (iv) recording the path of said stained vesicle in said glial cell by obtaining multiple images of said stained vesicle in said glial cell at distinct points in time; (v) determining a mobility parameter characterizing the mobility of said stained vesicle in said glial cell from at least one measurement of a length L between two distinct positions on said recorded path, and (vi) comparing said mobility parameter obtained in step (v) with a reference mobility parameter obtained by performing steps (i) to (v) with a mixture of FTY720 and FTY720-phosphate, wherein the result of said comparison in step (vi) is taken as a measure for the likelihood that said test compound is useful in the treatment of said disease. (i) providing a glial cell; (ii) staining at least one vesicle of said glial cell; (iii) contacting said glial cell with a test compound; (iv) recording the path of said stained vesicle in said glial cell by obtaining multiple images of said stained vesicle in said glial cell at distinct points in time; (v) determining a mobility parameter characterizing the mobility of said stained vesicle in said glial cell from at least one measurement of a length L between two distinct positions on said recorded path, and (vi) comparing said mobility parameter obtained in step (v) with a reference mobility parameter obtained by performing steps (i) to (v) with a mixture of FTY720 and FTY720-phosphate,
A device (118-a) comprising: at least one processor; and a memory operatively coupled to the at least one processor, the at least one processor configured to: receive a request to locate a control device (116-a), transmit acoustic token transmission information to the control device (116-a) to activate an electroacoustic transducer on the control device (116-a), receive an acoustic signal including an acoustic token signal from the control device (116-a) via a plurality of acoustic sensors (262-1-1, 262-1-2) operatively coupled to the at least one processor, and determine distance information of the control device (116-a) based on at least the received acoustic token signal generated by the electroacoustic transducer of the control device (116-a). at least one processor; and a memory operatively coupled to the at least one processor, the at least one processor configured to: receive a request to locate a control device (116-a), transmit acoustic token transmission information to the control device (116-a) to activate an electroacoustic transducer on the control device (116-a), receive an acoustic signal including an acoustic token signal from the control device (116-a) via a plurality of acoustic sensors (262-1-1, 262-1-2) operatively coupled to the at least one processor, and determine distance information of the control device (116-a) based on at least the received acoustic token signal generated by the electroacoustic transducer of the control device (116-a). receive a request to locate a control device (116-a), transmit acoustic token transmission information to the control device (116-a) to activate an electroacoustic transducer on the control device (116-a), receive an acoustic signal including an acoustic token signal from the control device (116-a) via a plurality of acoustic sensors (262-1-1, 262-1-2) operatively coupled to the at least one processor, and determine distance information of the control device (116-a) based on at least the received acoustic token signal generated by the electroacoustic transducer of the control device (116-a).
A mounting bracket arrangement for retrofitting an LED panel in between opposing end surfaces of a troffer, the mounting bracket arrangement comprising a pair of mounting brackets, each mounting bracket comprising: a major edge for abutting the mounting bracket against one of said end surfaces; an alignment edge extending transversely from the major edge; an affixing portion having a contact surface for contacting a roof section of the troffer; and a mounting hook extending from the affixing portion for hanging the LED panel from the mounting bracket, said mounting hook having an elongated slot or groove with an opening, and said slot or groove extends in a direction alongside the alignment edge, wherein each mounting bracket has a stepped profile comprising a first step portion, the affixing portion as a second step portion and an adjoining portion extending from the first step portion to the second step portion, wherein the mounting bracket arrangement further comprises a first edge shared by the first step portion, the adjoining portion and the second step portion; wherein the second step portion comprises a first further edge opposing the first edge, the mounting hook extending from the first further edge in the direction of the first step portion, each mounting bracket further comprising an alignment portion extending from the adjoining portion, wherein the alignment edge is shared by the first step portion, the adjoining portion and the alignment portion; wherein the alignment portion comprises a second further edge opposing the alignment edge, the first further edge and the second further edge facing each other and being spatially separated. a major edge for abutting the mounting bracket against one of said end surfaces; an alignment edge extending transversely from the major edge; an affixing portion having a contact surface for contacting a roof section of the troffer; and a mounting hook extending from the affixing portion for hanging the LED panel from the mounting bracket, said mounting hook having an elongated slot or groove with an opening, and said slot or groove extends in a direction alongside the alignment edge, wherein each mounting bracket has a stepped profile comprising a first step portion, the affixing portion as a second step portion and an adjoining portion extending from the first step portion to the second step portion, wherein the mounting bracket arrangement further comprises a first edge shared by the first step portion, the adjoining portion and the second step portion; wherein the second step portion comprises a first further edge opposing the first edge, the mounting hook extending from the first further edge in the direction of the first step portion, each mounting bracket further comprising an alignment portion extending from the adjoining portion, wherein the alignment edge is shared by the first step portion, the adjoining portion and the alignment portion; wherein the alignment portion comprises a second further edge opposing the alignment edge, the first further edge and the second further edge facing each other and being spatially separated.
A process for preparing a pre-paint composite comprising the steps of: a) contacting together a mixture of: i) an aqueous dispersion of TiO 2 particles and an adsorbing sulfur acid functionalized polymer; ii) an anionic surfactant; iii) sodium styrene sulfonate; and iv) a redox intitiator system; to form a first composite intermediate; then b) contacting under emulsion polymerization conditions the first composite intermediate with a first monomer emulsion comprising: i) methyl methacrylate or styrene or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; and iii) a carboxylic acid containing monomer under emulsion polymerization conditions; to form a second composite intermediate; then c) contacting the second composite intermediate with a second monomer emulsion comprising: i) styrene or methyl methacrylate or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; iii) carboxylic acid containing monomer; and iv) a secondary alcohol ethoxylate of the formula C 10-15 H 22-32 O(CH 2 CH 2 O) x H; to form an aqueous dispersion of TiO 2 particles with incomplete attachment of polymeric binder; where x is from 15 to 50 and the O(CH 2 CH 2 O) x H group is bonded to a CH group on the C 10-15 H 22-32 chain. a) contacting together a mixture of: i) an aqueous dispersion of TiO 2 particles and an adsorbing sulfur acid functionalized polymer; ii) an anionic surfactant; iii) sodium styrene sulfonate; and iv) a redox intitiator system; to form a first composite intermediate; then i) an aqueous dispersion of TiO 2 particles and an adsorbing sulfur acid functionalized polymer; ii) an anionic surfactant; iii) sodium styrene sulfonate; and iv) a redox intitiator system; b) contacting under emulsion polymerization conditions the first composite intermediate with a first monomer emulsion comprising: i) methyl methacrylate or styrene or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; and iii) a carboxylic acid containing monomer under emulsion polymerization conditions; to form a second composite intermediate; then i) methyl methacrylate or styrene or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; and iii) a carboxylic acid containing monomer under emulsion polymerization conditions; c) contacting the second composite intermediate with a second monomer emulsion comprising: i) styrene or methyl methacrylate or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; iii) carboxylic acid containing monomer; and iv) a secondary alcohol ethoxylate of the formula C 10-15 H 22-32 O(CH 2 CH 2 O) x H; to form an aqueous dispersion of TiO 2 particles with incomplete attachment of polymeric binder; where x is from 15 to 50 and the O(CH 2 CH 2 O) x H group is bonded to a CH group on the C 10-15 H 22-32 chain. i) styrene or methyl methacrylate or a combination thereof; ii) a C 1 -C 10 alkyl acrylate; iii) carboxylic acid containing monomer; and iv) a secondary alcohol ethoxylate of the formula C 10-15 H 22-32 O(CH 2 CH 2 O) x H; to form an aqueous dispersion of TiO 2 particles with incomplete attachment of polymeric binder; where x is from 15 to 50 and the O(CH 2 CH 2 O) x H group is bonded to a CH group on the C 10-15 H 22-32 chain.
A method in an LTE network comprising an eNodeB, eNB,, the eNB configured to receive data from a user equipment, UE, and egress the data to a cable modem, CM, the method comprising: determining, by the eNB in the LTE network, a hybrid automatic repeat request, HARQ, failure corresponding to a packet failing to be transmitted from the UE to the eNB over an air interface; setting, by the eNB in the LTE network, in response to determining the HARQ failure, a Bandwidth Report, BWR, subsequent to the HARQ failure to indicate an expected amount of data to be egressed from the eNB to the CM to be zero, wherein the BWR provides an estimation of an amount of data to be egressed from the eNB to the CM at a future time; determining, by the eNB in the LTE network, that the packet has been successfully retransmitted; and sending, by the eNB in the LTE network, the BWR to the CM, the BWR indicating an amount of expected new data sufficient to cover all received packets queued since determining the HARQ failure plus packets that are expected to egress the eNB a predetermined amount of time in the future. determining, by the eNB in the LTE network, a hybrid automatic repeat request, HARQ, failure corresponding to a packet failing to be transmitted from the UE to the eNB over an air interface; setting, by the eNB in the LTE network, in response to determining the HARQ failure, a Bandwidth Report, BWR, subsequent to the HARQ failure to indicate an expected amount of data to be egressed from the eNB to the CM to be zero, wherein the BWR provides an estimation of an amount of data to be egressed from the eNB to the CM at a future time; determining, by the eNB in the LTE network, that the packet has been successfully retransmitted; and sending, by the eNB in the LTE network, the BWR to the CM, the BWR indicating an amount of expected new data sufficient to cover all received packets queued since determining the HARQ failure plus packets that are expected to egress the eNB a predetermined amount of time in the future.
Installation frame for use in motor vehicle construction for defining a recess in a sunroof and for fastening and/or bracing a material of a roof liner around the recess and/or a lining towards the recess, the installation frame itself forming the connection between the roof liner and the roof, characterised in that the installation frame is produced in one piece from rigid polymeric material, namely dicyclopentadiene (DCPD) or poly-dicyclopentadiene (PDCPD), using the reaction injection moulding method, and the surface of the installation frame is primed and/or painted and thus sealed.
Layered product for use in growing plants comprising - at least one natural fiber layer comprising a web of natural fibers and - at least one SAP layer comprising a non-woven substrate comprising thermoplastic polymer fibers and a superabsorbent polymer adhered to thermoplastic polymer fibers, wherein the non-woven substrate is a high loft fabric, preferably a carded or an airlaid or spunlaid non-woven fabric, wherein the at least one SAP layer is in the form of a sheet, and wherein the at least one natural fiber layer and the one or more SAP layers are connected to each other by needle punching. - at least one natural fiber layer comprising a web of natural fibers and - at least one SAP layer comprising a non-woven substrate comprising thermoplastic polymer fibers and a superabsorbent polymer adhered to thermoplastic polymer fibers, preferably a carded or an airlaid or spunlaid non-woven fabric, wherein the at least one SAP layer is in the form of a sheet, and wherein the at least one natural fiber layer and the one or more SAP layers are connected to each other by needle punching.
A circular saw blade having a plurality of tips bonded at intervals on a peripheral portion of a base metal for cutting a workpiece with cutting edges formed on the plurality of tips, wherein each of the tips has a first rake face that is contiguous with the cutting edge, and a second rake face that faces a gullet provided in front of the tip in the rotational direction and has a radially inward inner edge that is in contact with an outer peripheral edge of the base metal that defines the gullet, wherein the first rake face is formed such that a first rake angle (θ1) is a negative angle relative to a first reference line drawn from a rotation center of the circular saw blade to the cutting edge; characterized in that the second rake face is formed such that a second rake angle (θ2), which is formed between the first reference line and a second reference line that passes through the radially inward inner edge along the second rake face, is a negative angle.
A dishwasher comprising a body; a washing tub which is disposed in the body and wherein the washing process is carried out; a draining element which is disposed on the base of the washing tub; a filter which is detachably mounted onto the draining element and which has a microfilter for holding dirt and a conical coarse filter which can be detachably mounted onto the microfilter and which holds dirt particles; and a salt container wherein the salt used for adjusting the hardness of water is filled, whereby the conical coarse filter has a first position where the coarse filter is placed onto the microfilter and a second position where the coarse filter is detached from the microfilter characterized by the conical coarse filter being placed onto the salt container in the second position and by the filter having a rotary element which is detachably mounted onto the coarse filter and which is used for adjusting the size of dirt particles which may pass through the coarse filter and the filter having a plurality of first openings arranged on the coarse filter and a plurality of second openings arranged on the rotary element so as to align with the first openings wherein the first openings and the second openings are displaced with the rotation of the rotary element being rotated over the coarse filter..
Method for a master device to access a value taken by a characteristic managed by a peripheral device in a local area network, said master and peripheral devices being able to communicate by means of a radio connection of BLE, Bluetooth Low Energy, type, said method comprising the following steps implemented by a first relay device belonging to the local area network and being located in an area of radio coverage of BLE type of the master device, the exchanges in the local area network being performed in accordance with a network protocol of UPnP type: - receiving a command to simulate the peripheral device from a device in the local area network, said peripheral device being located in an area of radio coverage of BLE type of a second relay device belonging to the local area network, said simulation command comprising an identifier and a MAC address of the peripheral device; - transmitting an advertisement message of a type which is in accordance with the BLE protocol, comprising said identifier and said MAC address of the peripheral device, the first relay device advertising the presence of the peripheral device in the area of radio coverage of BLE type of the master device; - establishing a radio connection of BLE type with the master device; - receiving, from the master device and by means of said radio connection, a request to read a value taken by a characteristic managed by the peripheral device; - receiving said value from the second relay device, said second relay device having obtained it by querying the peripheral device, and - sending the master device said value by means of said radio connection. - receiving a command to simulate the peripheral device from a device in the local area network, said peripheral device being located in an area of radio coverage of BLE type of a second relay device belonging to the local area network, said simulation command comprising an identifier and a MAC address of the peripheral device; - transmitting an advertisement message of a type which is in accordance with the BLE protocol, comprising said identifier and said MAC address of the peripheral device, the first relay device advertising the presence of the peripheral device in the area of radio coverage of BLE type of the master device; - establishing a radio connection of BLE type with the master device; - receiving, from the master device and by means of said radio connection, a request to read a value taken by a characteristic managed by the peripheral device; - receiving said value from the second relay device, said second relay device having obtained it by querying the peripheral device, and - sending the master device said value by means of said radio connection.
A mobile terminal comprising: a memory; a camera configured to acquire a preview picture including a picture of a subject, the preview picture includes only one subject; a display unit configured to display the preview picture; and a controller configured to: display, on the display unit, a guide object to provide guidance on taking the picture of the subject, process the preview picture and the guide object for matching a shape of the subject with a shape of the guide object, and automatically, take the preview picture if the shape of the subject matches the shape of the guide object by at least one reference value through the camera, characterized in that a whole image acquired by taking the preview picture includes both a preview image corresponding to the preview picture and an additional image corresponding to an additional picture capable of being taken by the camera, and the controller is further configured to: store the whole image in the memory; generate a final image by moving a position of the stored whole image to a position of the picture of the subject to correspond to a position of the guide object, and display the generated final image. a memory; a camera configured to acquire a preview picture including a picture of a subject, the preview picture includes only one subject; a display unit configured to display the preview picture; and a controller configured to: display, on the display unit, a guide object to provide guidance on taking the picture of the subject, process the preview picture and the guide object for matching a shape of the subject with a shape of the guide object, and automatically, take the preview picture if the shape of the subject matches the shape of the guide object by at least one reference value through the camera, characterized in that display, on the display unit, a guide object to provide guidance on taking the picture of the subject, process the preview picture and the guide object for matching a shape of the subject with a shape of the guide object, and automatically, take the preview picture if the shape of the subject matches the shape of the guide object by at least one reference value through the camera, a whole image acquired by taking the preview picture includes both a preview image corresponding to the preview picture and an additional image corresponding to an additional picture capable of being taken by the camera, and the controller is further configured to: store the whole image in the memory; generate a final image by moving a position of the stored whole image to a position of the picture of the subject to correspond to a position of the guide object, and display the generated final image.