A syringe for intra-articular injection, comprising: a hub having an orifice; a first barrel having an interior surface that forms a first barrel lumen; a first plunger having a head, the head of the first plunger slideably received in the first barrel lumen for movement therein, the head of the first plunger in sealing engagement with the interior surface of the first barrel; a second barrel having an interior surface that forms a second barrel lumen; a second plunger having a head, the head of the second plunger slideably received in the second barrel lumen for movement therein, the head of the second plunger in sealing engagement with the interior surface of the second barrel; a valve operable in a first condition to open a fluidly communicative path between the orifice of the hub and the first barrel lumen and to close a fluidly communicative path between the orifice of the hub and the second barrel lumen, and the valve operable in a second condition to open the fluidly communicative path between the orifice of the hub and the second barrel lumen and to close the fluidly communicative path between the orifice of the hub and the first barrel lumen; a needle that is coupled to the hub, and insertable into a joint; and a test indicator that is optically responsive to the presence of glucose in a bodily fluid, the test indicator positioned to be exposed to bodily fluid drawn into the first barrel lumen through the needle and visible from an exterior of the first barrel; wherein a defined visual indication by the test indicator indicates appropriate positioning of the needle in the joint, and wherein the needle may be repositioned if the test indicator does not indicate appropriate positioning. a hub having an orifice; a first barrel having an interior surface that forms a first barrel lumen; a first plunger having a head, the head of the first plunger slideably received in the first barrel lumen for movement therein, the head of the first plunger in sealing engagement with the interior surface of the first barrel; a second barrel having an interior surface that forms a second barrel lumen; a second plunger having a head, the head of the second plunger slideably received in the second barrel lumen for movement therein, the head of the second plunger in sealing engagement with the interior surface of the second barrel; a valve operable in a first condition to open a fluidly communicative path between the orifice of the hub and the first barrel lumen and to close a fluidly communicative path between the orifice of the hub and the second barrel lumen, and the valve operable in a second condition to open the fluidly communicative path between the orifice of the hub and the second barrel lumen and to close the fluidly communicative path between the orifice of the hub and the first barrel lumen; a needle that is coupled to the hub, and insertable into a joint; and a test indicator that is optically responsive to the presence of glucose in a bodily fluid, the test indicator positioned to be exposed to bodily fluid drawn into the first barrel lumen through the needle and visible from an exterior of the first barrel; wherein a defined visual indication by the test indicator indicates appropriate positioning of the needle in the joint, and wherein the needle may be repositioned if the test indicator does not indicate appropriate positioning.