A compound of Formula (Ia): wherein R 1 is NR c R d wherein R c is a 5 member cyclic ring that comprises a N atom, the H linked to the N atom is substituted with R 8 CO, wherein R 8 is C 1-4 alkyl, and R d is H, C 1-4 alkyl, C 1-4 alkenyl, or 3-7 member cyclic ring, said C 1-4 alkyl, C 1-4 alkenyl or 3-7 member cyclic ring being optionally substituted with OZ or NR 11 R 12, wherein Z, R 11, R 12 are independently H or C 1-4 alkyl; R 2 is absent, H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 3 is hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 5 is absent, H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 6 is H, halo, C 1-4 alkyl, C 2-4 alkoxy; or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 7 is H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 9 is H, hydroxyl, halo, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 10 is H, hydroxyl, halo, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; or R 1 and R 5 are part of 3-7 member cyclic ring, said 3-7 member cyclic being optionally substituted with C 1-4 alkyl optionally substituted with OZ, wherein Z is H or C 1-4 alkyl, or said 3-7 member cyclic being optionally substituted with R 8 CO, wherein R 8 is C 1-4 alkyl, or said 3-7 member cyclic being optionally substituted with SO 2 (CH 2) q H, wherein q is 1-4; or R 1 and R 2 are part of 3-7 member cyclic ring, optionally substituted with C 1-4 alkyl, said C 1-4 alkyl further optionally substituted with halo, or OZ, wherein Z is H or C 1-4 alkyl, or one or more members of said 3-7 member cyclic ring is optionally part of a carbonyl group or a sulfonyl group; or R 2 and R 6 are part of 3-7 member cyclic ring, optionally substituted with C 1-4 alkyl optionally substituted with OZ or NR 11 R 12 wherein Z, R 11 and R 12 are independently H or C 1-4 alkyl; R 4 is C 2 alkenyl optionally substituted with C 1-4 alkyl, -CH 2 OCH 3, or -CH 2 N(CH 3) 2; X is O, C 1-4 alkyl optionally substituted with halo, or NR b, wherein R b is H, or C 1-8 alkyl optionally substituted with halo; Y is C, CH optionally substituted with halo, or N; and A is C, CH optionally substituted with halo or N; or a pharmaceutically acceptable salt thereof. R 1 is NR c R d wherein R c is a 5 member cyclic ring that comprises a N atom, the H linked to the N atom is substituted with R 8 CO, wherein R 8 is C 1-4 alkyl, and R d is H, C 1-4 alkyl, C 1-4 alkenyl, or 3-7 member cyclic ring, said C 1-4 alkyl, C 1-4 alkenyl or 3-7 member cyclic ring being optionally substituted with OZ or NR 11 R 12, wherein Z, R 11, R 12 are independently H or C 1-4 alkyl; R c is a 5 member cyclic ring that comprises a N atom, the H linked to the N atom is substituted with R 8 CO, wherein R 8 is C 1-4 alkyl, and R d is H, C 1-4 alkyl, C 1-4 alkenyl, or 3-7 member cyclic ring, said C 1-4 alkyl, C 1-4 alkenyl or 3-7 member cyclic ring being optionally substituted with OZ or NR 11 R 12, wherein Z, R 11, R 12 are independently H or C 1-4 alkyl; R 2 is absent, H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 3 is hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 5 is absent, H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 6 is H, halo, C 1-4 alkyl, C 2-4 alkoxy; or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 7 is H, halo, C 1-4 alkyl, C 2-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 9 is H, hydroxyl, halo, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; R 10 is H, hydroxyl, halo, C 1-4 alkyl, C 1-4 alkoxy, or alkylamine (NR 11 R 12), wherein R 11 and R 12 are independently H or C 1-4 alkyl; or R 1 and R 5 are part of 3-7 member cyclic ring, said 3-7 member cyclic being optionally substituted with C 1-4 alkyl optionally substituted with OZ, wherein Z is H or C 1-4 alkyl, or said 3-7 member cyclic being optionally substituted with R 8 CO, wherein R 8 is C 1-4 alkyl, or said 3-7 member cyclic being optionally substituted with SO 2 (CH 2) q H, wherein q is 1-4; or R 1 and R 2 are part of 3-7 member cyclic ring, optionally substituted with C 1-4 alkyl, said C 1-4 alkyl further optionally substituted with halo, or OZ, wherein Z is H or C 1-4 alkyl, or one or more members of said 3-7 member cyclic ring is optionally part of a carbonyl group or a sulfonyl group; or R 2 and R 6 are part of 3-7 member cyclic ring, optionally substituted with C 1-4 alkyl optionally substituted with OZ or NR 11 R 12 wherein Z, R 11 and R 12 are independently H or C 1-4 alkyl; R 4 is C 2 alkenyl optionally substituted with C 1-4 alkyl, -CH 2 OCH 3, or -CH 2 N(CH 3) 2; X is O, C 1-4 alkyl optionally substituted with halo, or NR b, wherein R b is H, or C 1-8 alkyl optionally substituted with halo; Y is C, CH optionally substituted with halo, or N; and A is C, CH optionally substituted with halo or N;