A method of determining an estimated neural response in a hybrid acoustic-electrical audio prosthesis comprising: recording a B response by target nerve tissue to a first stimulus sequence which includes: i. delivering to the target nerve tissue a first electrical stimulus pulse P1 to elicit a corresponding action potential followed by a relative refractory period, and ii. after the relative refractory period, delivering to the target nerve tissue a second electrical stimulus pulse P2 and an associated acoustic stimulation signal; recording an E response by the target nerve tissue to a second stimulus sequence which includes: i. delivering to the target nerve tissue a third electrical stimulus pulse P3 to elicit a corresponding action potential followed by a relative refractory period, and ii. within the relative refractory period, delivering to the target nerve tissue a fourth electrical stimulus pulse P4; recording a C response by the target nerve tissue to delivery of a first reference electrical stimulus pulse P5 corresponding to the first stimulus pulse P1; recording a D response by the target nerve tissue to delivery of a second reference electrical stimulus pulse P6 corresponding to the third stimulus pulse P3; processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y = (B-C)-(E-D). recording a B response by target nerve tissue to a first stimulus sequence which includes: i. delivering to the target nerve tissue a first electrical stimulus pulse P1 to elicit a corresponding action potential followed by a relative refractory period, and ii. after the relative refractory period, delivering to the target nerve tissue a second electrical stimulus pulse P2 and an associated acoustic stimulation signal; i. delivering to the target nerve tissue a first electrical stimulus pulse P1 to elicit a corresponding action potential followed by a relative refractory period, and ii. after the relative refractory period, delivering to the target nerve tissue a second electrical stimulus pulse P2 and an associated acoustic stimulation signal; recording an E response by the target nerve tissue to a second stimulus sequence which includes: i. delivering to the target nerve tissue a third electrical stimulus pulse P3 to elicit a corresponding action potential followed by a relative refractory period, and ii. within the relative refractory period, delivering to the target nerve tissue a fourth electrical stimulus pulse P4; i. delivering to the target nerve tissue a third electrical stimulus pulse P3 to elicit a corresponding action potential followed by a relative refractory period, and ii. within the relative refractory period, delivering to the target nerve tissue a fourth electrical stimulus pulse P4; recording a C response by the target nerve tissue to delivery of a first reference electrical stimulus pulse P5 corresponding to the first stimulus pulse P1; recording a D response by the target nerve tissue to delivery of a second reference electrical stimulus pulse P6 corresponding to the third stimulus pulse P3; processing the recorded responses to determine an artifact canceled estimated neural response Y following the relation Y = (B-C)-(E-D).