A catheter system for accessing an anatomy of a patient, comprising: a syringe including a first chamber and a distal syringe end portion, wherein the distal syringe end portion defines a conduit distally extending to a distal syringe opening such that the conduit fluidly connects the first chamber to the distal syringe opening, wherein the syringe further includes a second chamber in communication with the conduit, wherein the first and second chambers (72, 74) respectively define longitudinal chamber axes in parallel with each other; an access needle defining a needle lumen longitudinally extending therethrough and secured relative to the distal syringe end portion such that the access needle distally projects from the distal syringe end portion; a pliable catheter releasably secured relative to the access needle such that the access needle is received within the pliable catheter; and a guidewire operatively connected to the syringe and distally extending through the conduit toward the distal syringe opening, wherein the guidewire extends from the second chamber and into the conduit, wherein the guidewire is configured to selectively move through the conduit, the distal syringe opening, and along the needle lumen to thereby guide movement of the pliable catheter relative to the access needle for introducing the pliable catheter into the patient, wherein the conduit of the distal syringe end portion includes a first proximal lumen, a second proximal lumen, and a distal lumen fluidly connected to the distal syringe opening, wherein the first and second proximal lumens (84, 82) respectively communicate with the first and second chamber (72, 74) and intersect at the distal lumen for communicating fluid and the guidewire through the distal syringe opening; wherein the syringe further includes a fluid seal positioned in the second proximal lumen, wherein the fluid seal is configured to moveably receive the guidewire therethrough while inhibiting a bodily fluid from being introduced into the second chamber; wherein the guidewire is movable from a proximal guidewire position to a distal guidewire position, wherein the second chamber contains at least a portion of the guidewire extending coaxially along the longitudinal chamber axis of the second chamber, such that the guidewire remains confined in the second chamber and movable between the proximal and distal guidewire positions, and the second chamber includes a sidewall extending along a sidewall of the first chamber. a syringe including a first chamber and a distal syringe end portion, wherein the distal syringe end portion defines a conduit distally extending to a distal syringe opening such that the conduit fluidly connects the first chamber to the distal syringe opening, wherein the syringe further includes a second chamber in communication with the conduit, wherein the first and second chambers (72, 74) respectively define longitudinal chamber axes in parallel with each other; an access needle defining a needle lumen longitudinally extending therethrough and secured relative to the distal syringe end portion such that the access needle distally projects from the distal syringe end portion; a pliable catheter releasably secured relative to the access needle such that the access needle is received within the pliable catheter; and a guidewire operatively connected to the syringe and distally extending through the conduit toward the distal syringe opening, wherein the guidewire extends from the second chamber and into the conduit, wherein the guidewire is configured to selectively move through the conduit, the distal syringe opening, and along the needle lumen to thereby guide movement of the pliable catheter relative to the access needle for introducing the pliable catheter into the patient, wherein the conduit of the distal syringe end portion includes a first proximal lumen, a second proximal lumen, and a distal lumen fluidly connected to the distal syringe opening, wherein the first and second proximal lumens (84, 82) respectively communicate with the first and second chamber (72, 74) and intersect at the distal lumen for communicating fluid and the guidewire through the distal syringe opening; wherein the syringe further includes a fluid seal positioned in the second proximal lumen, wherein the fluid seal is configured to moveably receive the guidewire therethrough while inhibiting a bodily fluid from being introduced into the second chamber; wherein the guidewire is movable from a proximal guidewire position to a distal guidewire position, wherein the second chamber contains at least a portion of the guidewire extending coaxially along the longitudinal chamber axis of the second chamber, such that the guidewire remains confined in the second chamber and movable between the proximal and distal guidewire positions, and the second chamber includes a sidewall extending along a sidewall of the first chamber.