A compound of Formula wherein X is -(CR 10 R 11) m -, heteroaryl or heterocyclyl, Y and Z are independently C=O, -O-, -NR 9 -, -CONH-, -NHCO- or may be absent; R 1 and R 2 are independently alkyl, cycloalkyl, cycloalkylalkyl, arylalkyl, aryl, or R 1 and R 2 are independently optionally substituted thioalkyl wherein the substituents attached to the S atom of the thioalkyl are alkyl, branched alkyl, heterocyclyl, -(CH 2) v COR 20, -CH 2 CHR 21 COR 22 or -CH 2 R 23; wherein v = 1-3, R 20 and R 22 are independently selected from OH, NR 24 R 25 or OR 26, R 21 is NR 24 R 25, R 23 is optionally substituted aryl or optionally substituted heterocyclyl, where the optional substituents include alkyl and halogen, R 24 is hydrogen or alkyl, R 25 is hydrogen, alkyl, branched alkyl, arylalkyl, heterocyclyl, -CH 2 (OCH 2 CH 2 O) m CH 3, or a polyamine chain, R 26 is optionally substituted alkyl, where the optional substituents are OH, halogen or NH 2, w = 1-8; R 3 and R 4 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl, wherein the substituents are alkyl, halogen or OH; R 5, R 6, R 7 and R 8 are independently hydrogen, alkyl or cycloalkyl; R 9 is hydrogen, alkyl, cycloalkyl or CO alkyl; R 10 and R 11 are independently hydrogen, halogen or alkyl; R 12 and R 13 are independently hydrogen, halogen or alkyl, or R 12 and R 13 can be taken together to form a carbocyclic ring; R 14, R 15, R 16, R 17 and R 18 are independently hydrogen, halogen, alkyl or OR 19; R 19 is hydrogen, alkyl or cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q is 0, 1, 2, 3, or 4; r is 0 or 1; t is 1, 2, or 3; and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. X is -(CR 10 R 11) m -, heteroaryl or heterocyclyl, Y and Z are independently C=O, -O-, -NR 9 -, -CONH-, -NHCO- or may be absent; R 1 and R 2 are independently alkyl, cycloalkyl, cycloalkylalkyl, arylalkyl, aryl, or R 1 and R 2 are independently optionally substituted thioalkyl wherein the substituents attached to the S atom of the thioalkyl are alkyl, branched alkyl, heterocyclyl, -(CH 2) v COR 20, -CH 2 CHR 21 COR 22 or -CH 2 R 23; wherein v = 1-3, R 20 and R 22 are independently selected from OH, NR 24 R 25 or OR 26, R 21 is NR 24 R 25, R 23 is optionally substituted aryl or optionally substituted heterocyclyl, where the optional substituents include alkyl and halogen, R 24 is hydrogen or alkyl, R 25 is hydrogen, alkyl, branched alkyl, arylalkyl, heterocyclyl, -CH 2 (OCH 2 CH 2 O) m CH 3, or a polyamine chain, R 26 is optionally substituted alkyl, where the optional substituents are OH, halogen or NH 2, w = 1-8; v = 1-3, R 20 and R 22 are independently selected from OH, NR 24 R 25 or OR 26, R 21 is NR 24 R 25, R 23 is optionally substituted aryl or optionally substituted heterocyclyl, where the optional substituents include alkyl and halogen, R 24 is hydrogen or alkyl, R 25 is hydrogen, alkyl, branched alkyl, arylalkyl, heterocyclyl, -CH 2 (OCH 2 CH 2 O) m CH 3, or a polyamine chain, R 26 is optionally substituted alkyl, where the optional substituents are OH, halogen or NH 2, w = 1-8; R 3 and R 4 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl, wherein the substituents are alkyl, halogen or OH; R 5, R 6, R 7 and R 8 are independently hydrogen, alkyl or cycloalkyl; R 9 is hydrogen, alkyl, cycloalkyl or CO alkyl; R 10 and R 11 are independently hydrogen, halogen or alkyl; R 12 and R 13 are independently hydrogen, halogen or alkyl, or R 12 and R 13 can be taken together to form a carbocyclic ring; R 14, R 15, R 16, R 17 and R 18 are independently hydrogen, halogen, alkyl or OR 19; R 19 is hydrogen, alkyl or cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q is 0, 1, 2, 3, or 4; r is 0 or 1; t is 1, 2, or 3;