A biopsy system comprising an actuator device and a biopsy needle arrangement, the actuator device comprises: a frame, a first actuator, a second actuator, and a third actuator, and the biopsy needle arrangement comprises: a needle sheath and a needle, - the first, second and third actuators (321, 322, 323) being configured to move in relation to the frame and operatively connected to the biopsy needle arrangement, - the needle sheath having proximal end and a distal end, the needle sheath constituting an elongated tube having a sheath opening at the distal end of the needle sheath, - the needle having proximal end and a distal end and a length that is greater than the length of the needle sheath, the needle comprising an elongated shaft portion configured to fit inside and slide relative to the needle sheath, and a tip portion connected to the shaft portion and located at the distal end of the needle, the tip portion having a transverse extension, or width, that is greater than a transverse extension, or width, of the sheath opening, - the biopsy needle arrangement having a closed state and an open state, the tip portion abutting the needle sheath in the closed state, and the tip portion extending from the distal end of the needle sheath in the open state, - the first actuator being configured to be operatively connected to the needle and configured to, with the needle arrangement in its closed state, push the needle distally in a sliding direction (x) relative to the needle sheath a first distance, d1, at which the needle arrangement is in its open state, - the second actuator being configured to be operatively connected to the needle sheath and configured to, with the needle arrangement in its open state, push the needle sheath distally in the sliding direction (x) relative to the needle a second distance, d2, - the third actuator being configured to be operatively connected to the needle sheath and configured to, with the needle arrangement in its open state, push the needle sheath distally in the sliding direction (x) relative to the needle a third distance, d3, where d3 is smaller than d2, at which the needle arrangement is in its closed state, - the first actuator being configured to push the needle in motion having a first maximum velocity, v1, the second actuator is configured to push the needle sheath in motion having a second maximum velocity, v2, and the third actuator is configured to push the needle sheath in motion having a third maximum velocity, v3, where v3 is smaller than v2. - the first, second and third actuators (321, 322, 323) being configured to move in relation to the frame and operatively connected to the biopsy needle arrangement, - the needle sheath having proximal end and a distal end, the needle sheath constituting an elongated tube having a sheath opening at the distal end of the needle sheath, - the needle having proximal end and a distal end and a length that is greater than the length of the needle sheath, the needle comprising an elongated shaft portion configured to fit inside and slide relative to the needle sheath, and a tip portion connected to the shaft portion and located at the distal end of the needle, the tip portion having a transverse extension, or width, that is greater than a transverse extension, or width, of the sheath opening, - the biopsy needle arrangement having a closed state and an open state, the tip portion abutting the needle sheath in the closed state, and the tip portion extending from the distal end of the needle sheath in the open state, - the first actuator being configured to be operatively connected to the needle and configured to, with the needle arrangement in its closed state, push the needle distally in a sliding direction (x) relative to the needle sheath a first distance, d1, at which the needle arrangement is in its open state, - the second actuator being configured to be operatively connected to the needle sheath and configured to, with the needle arrangement in its open state, push the needle sheath distally in the sliding direction (x) relative to the needle a second distance, d2, - the third actuator being configured to be operatively connected to the needle sheath and configured to, with the needle arrangement in its open state, push the needle sheath distally in the sliding direction (x) relative to the needle a third distance, d3, where d3 is smaller than d2, at which the needle arrangement is in its closed state, - the first actuator being configured to push the needle in motion having a first maximum velocity, v1, the second actuator is configured to push the needle sheath in motion having a second maximum velocity, v2, and the third actuator is configured to push the needle sheath in motion having a third maximum velocity, v3, where v3 is smaller than v2.