A compound comprising a modified oligonucleotide, wherein the nucleobase sequence of the modified oligonucleotide is complementary to miR-21 (SEQ ID NO: 1) and wherein the modified oligonucleotide: a) consists of 18 or 19 linked nucleosides, and wherein the modified oligonucleotide comprises at least 18 contiguous nucleosides of the following nucleoside pattern VII in the 5' to 3' orientation: N M -(N B -N M -N M) 2 -N M -(N B -N Q -N Q -N Q) 2 -N B -N B -N Z wherein each N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; and N Z is a modified nucleoside; or b) consists of 21 or 22 linked nucleosides, and wherein the modified oligonucleotide comprises at least 21 contiguous nucleosides of the following nucleoside pattern III in the 5' to 3' orientation: X -N B -N Q -N Q -N B -(N Q -N Q -N Q -N B) 3 -N Y -N Z wherein each R is a non-bicyclic nucleoside; X is from 1 to 4; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and each N Z is a modified nucleoside; or c) consists of 18 or 19 linked nucleosides, wherein the modified oligonucleotide comprises at least 18 contiguous nucleosides of the following nucleoside pattern IV in the 5' to 3' orientation: N M -N B -N Q -N Q -N B -(N Q -N Q -N Q -N B) 3 -N Y -N Z wherein N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and N Z is a modified nucleoside. a) consists of 18 or 19 linked nucleosides, and wherein the modified oligonucleotide comprises at least 18 contiguous nucleosides of the following nucleoside pattern VII in the 5' to 3' orientation: N M -(N B -N M -N M) 2 -N M -(N B -N Q -N Q -N Q) 2 -N B -N B -N Z wherein each N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; and N Z is a modified nucleoside; or wherein each N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; and N Z is a modified nucleoside; or b) consists of 21 or 22 linked nucleosides, and wherein the modified oligonucleotide comprises at least 21 contiguous nucleosides of the following nucleoside pattern III in the 5' to 3' orientation: X -N B -N Q -N Q -N B -(N Q -N Q -N Q -N B) 3 -N Y -N Z wherein each R is a non-bicyclic nucleoside; X is from 1 to 4; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and each N Z is a modified nucleoside; or wherein each R is a non-bicyclic nucleoside; X is from 1 to 4; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and each N Z is a modified nucleoside; or c) consists of 18 or 19 linked nucleosides, wherein the modified oligonucleotide comprises at least 18 contiguous nucleosides of the following nucleoside pattern IV in the 5' to 3' orientation: N M -N B -N Q -N Q -N B -(N Q -N Q -N Q -N B) 3 -N Y -N Z wherein N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and N Z is a modified nucleoside. wherein N M is a modified nucleoside that is not a bicyclic nucleoside; each N B is a bicyclic nucleoside; each N Q is a non-bicyclic nucleoside; N Y is a bicyclic nucleoside; and N Z is a modified nucleoside.