A surgical system comprising: a vascular closure device (10, 310) comprising: a release component that is elongate along a longitudinal direction, the release component defining a distal end and a proximal end spaced from the distal end along the longitudinal direction, the release component comprising a release component channel; a delivery component disposed along the release component along the longitudinal direction, the delivery component including a delivery component body and a delivery channel, wherein at least one of the release component and the delivery component is moveable relative to the other of the release component and the delivery component, wherein the release component channel is sized to slidably receive a portion of the delivery component; a sealing device having a toggle that is configured to be initially trapped between the delivery component and the release component, a suture that is attached to the toggle and extends through the delivery channel, a plug that is attached to the suture relative to the toggle in a proximal direction, and a locking member, the proximal direction extending from the distal end toward the proximal end of the release component; and at least one actuator that is coupled to the release component and is in communication with the suture such that actuation of the at least one actuator causes (i) at least one of the release component and the delivery component to move relative to the other of the release component and the delivery component so as to release the toggle from the release component, and (ii) the suture to be pulled in the proximal direction to thereby place the suture in tension and urge the toggle against a distal end of the delivery component such that the toggle is oriented in a sealing position; wherein the surgical system further comprises: an access sheath; wherein the vascular closure device (10, 310) is configured to be positioned within the access sheath. a release component that is elongate along a longitudinal direction, the release component defining a distal end and a proximal end spaced from the distal end along the longitudinal direction, the release component comprising a release component channel; a delivery component disposed along the release component along the longitudinal direction, the delivery component including a delivery component body and a delivery channel, wherein at least one of the release component and the delivery component is moveable relative to the other of the release component and the delivery component, wherein the release component channel is sized to slidably receive a portion of the delivery component; a sealing device having a toggle that is configured to be initially trapped between the delivery component and the release component, a suture that is attached to the toggle and extends through the delivery channel, a plug that is attached to the suture relative to the toggle in a proximal direction, and a locking member, the proximal direction extending from the distal end toward the proximal end of the release component; and at least one actuator that is coupled to the release component and is in communication with the suture such that actuation of the at least one actuator causes (i) at least one of the release component and the delivery component to move relative to the other of the release component and the delivery component so as to release the toggle from the release component, and (ii) the suture to be pulled in the proximal direction to thereby place the suture in tension and urge the toggle against a distal end of the delivery component such that the toggle is oriented in a sealing position; wherein the surgical system further comprises: an access sheath; wherein the vascular closure device (10, 310) is configured to be positioned within the access sheath. an access sheath; wherein the vascular closure device (10, 310) is configured to be positioned within the access sheath.