mhurhangee/ep-ind-claims huggingface dataset:
A method of synthesizing a peptide product comprising at least one cyclic imide group of formula or a salt or solvate thereof: wherein R 1 is a bridge of one or two atoms lengths, R 2 is an amino acid side chain, * denotes an asymmetric C atom, and (*) denotes an optionally asymmetric C atom, comprising the steps: (a) coupling a synthesis building block of formula: wherein X is a base-labile amino protecting group, Y is an unprotected carboxy or carboxamido group, * denotes an asymmetric C atom, and Z is a carboxy group, to a peptide product of formula wherein R 2' is an optionally protected amino acid side chain, R 3 is a peptidic residue, and (*) denotes an optionally asymmetric C atom under conditions wherein the cyclic imide group of formula is formed and wherein the coupling conditions comprise a reaction time of at least 12 h, a temperature of between 15 and 40°C, repeated addition of coupling reagents such as TBTU or HBTU with DIPEA or HOBt/DIC and dimethylformamide as organic solvent (b) cleaving off the amino protecting group X, wherein said step (b) is not carried out with piperidine as deprotecting agent, (c) optionally continuing the peptide synthesis, and (d) optionally purifying the peptide product. R 1 is a bridge of one or two atoms lengths, R 2 is an amino acid side chain, * denotes an asymmetric C atom, and (*) denotes an optionally asymmetric C atom, (a) coupling a synthesis building block of formula: wherein X is a base-labile amino protecting group, Y is an unprotected carboxy or carboxamido group, * denotes an asymmetric C atom, and Z is a carboxy group, to a peptide product of formula wherein R 2' is an optionally protected amino acid side chain, R 3 is a peptidic residue, and (*) denotes an optionally asymmetric C atom under conditions wherein the cyclic imide group of formula is formed and wherein the coupling conditions comprise a reaction time of at least 12 h, a temperature of between 15 and 40°C, repeated addition of coupling reagents such as TBTU or HBTU with DIPEA or HOBt/DIC and dimethylformamide as organic solvent X is a base-labile amino protecting group, Y is an unprotected carboxy or carboxamido group, * denotes an asymmetric C atom, and Z is a carboxy group, R 2' is an optionally protected amino acid side chain, R 3 is a peptidic residue, and (*) denotes an optionally asymmetric C atom (b) cleaving off the amino protecting group X, wherein said step (b) is not carried out with piperidine as deprotecting agent, (c) optionally continuing the peptide synthesis, and (d) optionally purifying the peptide product.
An internal combustion engine having adjustable and reciprocating piston sleeves, comprising: an engine block comprising a cylinder including an intake port, an exhaust port, two linearly opposing pistons reciprocatingly mounted relative to two opposing rotating crankshafts, and a pair of opposing rotating eccentric shafts mounted parallel to the crankshafts and moveable relative to the crankshafts; a pair of piston sleeves reciprocatingly mounted in the cylinder around each piston and mounted relative to their respective eccentric shafts, each piston sleeve having a slotted port in communication with either the intake port or the exhaust port; a pair of sleeve couplers pivotably connected to their respective piston sleeves and eccentrically rotatable relative to their respective eccentric shafts; characterized in that the internal combustion engine comprises a crankshaft gear disposed at an end of each crankshaft; an eccentric shaft gear disposed at an end of each eccentric shaft; a means for coupling the crankshaft gears and eccentric shaft gears; and a pair of phase couplers helically moveable about their respective eccentric shafts, where the phase couplers are pivotably fixed and slidable relative to their respective eccentric shaft gears, such that helical movement of the phase couplers about their respective eccentric shafts changes the relation of timing between the reciprocating pistons and the piston sleeves and movement of the eccentric shaft relative to the crankshaft changes the overlap between the slotted port of each piston sleeve relative to either the intake port or the exhaust port. an engine block comprising a cylinder including an intake port, an exhaust port, two linearly opposing pistons reciprocatingly mounted relative to two opposing rotating crankshafts, and a pair of opposing rotating eccentric shafts mounted parallel to the crankshafts and moveable relative to the crankshafts; a pair of piston sleeves reciprocatingly mounted in the cylinder around each piston and mounted relative to their respective eccentric shafts, each piston sleeve having a slotted port in communication with either the intake port or the exhaust port; a pair of sleeve couplers pivotably connected to their respective piston sleeves and eccentrically rotatable relative to their respective eccentric shafts; characterized in that the internal combustion engine comprises a crankshaft gear disposed at an end of each crankshaft; an eccentric shaft gear disposed at an end of each eccentric shaft; a means for coupling the crankshaft gears and eccentric shaft gears; and a pair of phase couplers helically moveable about their respective eccentric shafts, where the phase couplers are pivotably fixed and slidable relative to their respective eccentric shaft gears, such that helical movement of the phase couplers about their respective eccentric shafts changes the relation of timing between the reciprocating pistons and the piston sleeves and movement of the eccentric shaft relative to the crankshaft changes the overlap between the slotted port of each piston sleeve relative to either the intake port or the exhaust port.
A socket, comprising a socket body, wherein the socket body is provided with at least two plug positions, wherein each plug position is provided with an earth line contact (122, 132), a live line contact (121, 131) and a neutral line contact (123, 133); and a socket accommodating cavity that is provided with a live line metal elastic sheet and a neutral line metal elastic sheet, and wherein the above metal elastic sheets are configured to be connected to or disconnected from the live line contact (121, 131) and neutral line contact (123, 133), respectively, under magnetic force, wherein the socket body is internally provided with a first fixed block and a second fixed block, wherein the first fixed block is connected with a first metal spring, wherein one side of the first live line contact is connected with a first metal connecting plate, and one side of the second live line contact is connected with a second metal connecting plate, wherein both ends of the first metal spring are directly above the first metal connecting plate and the second metal connecting plate, wherein the second fixed block is connected with a second metal spring plate, wherein a third metal connecting plate is connected at one side of the first neutral line contact, and a fourth metal connecting plate is connected at one side of the second neutral line contact, wherein both ends of the second metal spring plate are directly above the third metal connecting plate and the fourth metal connecting plate, wherein the first earth line contact and the second earth line contact are connected through an additional third metal connecting plate, wherein heights of the earth line contact (122, 132), live line contact (121, 131) and neutral line contact (123, 133) are lower than that of the plug positions, and/or, wherein the live line contact (121, 131) and the neutral line contact (123, 133) are provided respectively on both sides of the earth line contact (122, 132), and/or, wherein a height of the earth line contact (122, 132) is higher than that of live 2 line contact (121, 131) and neutral line contact (123, 133), and/or, wherein no insulating ring is available around the earth line contact (122, 132), live line contact (121, 131) and neutral line contact (123, 133). and/or, wherein the live line contact (121, 131) and the neutral line contact (123, 133) are provided respectively on both sides of the earth line contact (122, 132), and/or, wherein a height of the earth line contact (122, 132) is higher than that of live 2 line contact (121, 131) and neutral line contact (123, 133), and/or, wherein no insulating ring is available around the earth line contact (122, 132), live line contact (121, 131) and neutral line contact (123, 133).
A thermostat device characterized by having: a first coolant flow path; a second coolant flow path; a casing including a thermostat container portion that communicates with the first and second coolant flow paths; a third coolant flow path that communicates with the thermostat container portion, a cap that covers the thermostat container portion; a thermostat including a thermo-element that advances and retreats in response to changes in temperature of a coolant that flows through the thermostat container portion, with the thermo-element closing the first coolant flow path, the third coolant flow path, the third coolant flow path side of the thermostat container portion, and the second coolant flow path are put into communication with each other, and with the thermo-element opening the first coolant flow path, the first coolant flow path side of the thermostat container portion and the second coolant flow path are put into communication with each other; a temperature sensor disposed facing into the thermostat container portion and which detects the temperature of the coolant; characterized in that a sensor mount in which the temperature sensor is embedded, is integrated into an inside end of the cap; and a lead connector extends from the temperature sensor and is integrated into an outside end of the cap. a first coolant flow path; a second coolant flow path; a casing including a thermostat container portion that communicates with the first and second coolant flow paths; a third coolant flow path that communicates with the thermostat container portion, a cap that covers the thermostat container portion; a thermostat including a thermo-element that advances and retreats in response to changes in temperature of a coolant that flows through the thermostat container portion, with the thermo-element closing the first coolant flow path, the third coolant flow path, the third coolant flow path side of the thermostat container portion, and the second coolant flow path are put into communication with each other, and with the thermo-element opening the first coolant flow path, the first coolant flow path side of the thermostat container portion and the second coolant flow path are put into communication with each other; a temperature sensor disposed facing into the thermostat container portion and which detects the temperature of the coolant; characterized in that a sensor mount in which the temperature sensor is embedded, is integrated into an inside end of the cap; and a lead connector extends from the temperature sensor and is integrated into an outside end of the cap.
Connecting element for an end region of a first support band of garments such as corsetry, in particular of lingerie, which is to be connected to a second support band of the corsetry, wherein the connecting element has a plurality of band plies (1, 10; 30, 31), of which at least one band ply supports a connecting part, such as at least one hook, one eyelet or the like, and, between two band plies (1, 10; 30, 31), a liner (20; 40) is provided to increase the wearing comfort, which liner (20; 40) is secured to at least one of the band plies (1, 10; 30, 31) by means of a connection in the region of side edges of the connecting element, wherein the connection is located at least partially between band plies by the turning back/folding back of at least one of the band plies (1,10; 30, 31), characterized in that the liner (20, 40), which was previously arranged on an outer face of the connecting element, is brought between two band plies (1, 10; 30, 31) by turning back/folding back at least one of the band plies (1, 10; 30, 31).
An air purifier comprising a body having an air inlet through which the ambient air is sucked, a clean air outlet through which the cleaned air is released to the environment and a CO 2 outlet through which the carbon dioxide separated from the air is discharged to the outside; a base tank containing a basic solution for converting the carbon dioxide in the air into carbonate solution and thus chemically adsorbing the same; a mixture tank which receives the carbonate solution to be processed with an acidic solution, and an acid tank which supplies the acidic solution to the mixture tank, characterized by a shelf comprising a housing which has an inclined base and wherein the acid tank, the base tank or the mixture tank is placed; an opening which is provided on the base, a pipe which is connected to the opening; and a measurement receptacle which has a channel connected to the other end of the pipe.
Dental abrasive instrument, comprising - a shaft and - an abrasive region arranged on the shaft, - wherein the abrasive region comprises a bonding layer and abrasive elements comprising abrasive particles and spheres, and - wherein the abrasive elements are partially embedded in the bonding layer, which is applied to the shaft, and are fixed to the shaft by means of the bonding layer. - a shaft and - an abrasive region arranged on the shaft, - wherein the abrasive region comprises a bonding layer and abrasive elements comprising abrasive particles and spheres, and - wherein the abrasive elements are partially embedded in the bonding layer, which is applied to the shaft, and are fixed to the shaft by means of the bonding layer.
A method of forming a tapered structure, the method comprising: feeding stock (102, 602) into a curving device; and having the stock (102, 602) meet a predecessor portion of stock along one or more adjacent edges, characterized in that: the feeding stock is realized such that each point on the stock undergoes rotational motion about a peak location of the tapered structure, i.e. each point on the incoming sheet of stock (102, 602) is at a constant distance from the peak location of the tapered structure as the stock (102, 602) is deformed by the curving device, such that the curving device does not impart in-plane deformation to the stock (102, 602).
A method for producing a composite material with a decorative coating, comprising the steps of: - providing a glass or glass ceramic substrate; - applying a layer of a sol-gel material that includes at least added pigment particles and oxide particles; - applying a polymer layer on the sol-gel layer, wherein the sol-gel layer is infiltrated by the material of the polymer layer, wherein a polysiloxane is used as a material for the polymer layer; - wherein pigments are added to the material of the polymer layer; characterised in that oxide particles of fibrous and/or chain-like morphology are added to the sol-gel. - providing a glass or glass ceramic substrate; - applying a layer of a sol-gel material that includes at least added pigment particles and oxide particles; - applying a polymer layer on the sol-gel layer, wherein the sol-gel layer is infiltrated by the material of the polymer layer, wherein a polysiloxane is used as a material for the polymer layer; - wherein pigments are added to the material of the polymer layer;
A laser irradiation device comprising: a semiconductor laser oscillator having laser diodes arranged two-dimensionally in fast-axis and slow-axis directions; and a homogenizer (24, 26) to which a laser beam emitted from the semiconductor laser oscillator is incident, and which is configured to condense the laser beam onto a long-length incident region at a surface to be irradiated, the homogenizer (24, 26) including a rectangular opening, a laser beam incident on the inside of which reaching the surface to be irradiated, and wherein the homogenizer (24, 26) divides the laser beam into a plurality of beams with respect to a short-axis direction of the incident region, and superimposes the plurality of divided beams on the surface to be irradiated to cause the superimposed beams to be incident on the incident region, characterized in that the slow-axis direction of the semiconductor laser oscillator is inclined with respect to a long-axis direction of the incident region, wherein at an incident position to the homogenizer (24, 26), a profile of the laser beam shows a maximum value periodically at a pitch P with respect to the fast-axis direction, and when a dimension of a cross-section of the laser beam at the incident position to the homogenizer (24, 26) in the long-axis direction is denoted by L, and an inclined angle between the slow-axis direction of the semiconductor laser oscillator and the long-axis direction is denoted by θ, the inclined angle θ is in a range of 0.5 times to 1.5 times sin -1 (P/L). a semiconductor laser oscillator having laser diodes arranged two-dimensionally in fast-axis and slow-axis directions; and a homogenizer (24, 26) to which a laser beam emitted from the semiconductor laser oscillator is incident, and which is configured to condense the laser beam onto a long-length incident region at a surface to be irradiated, the homogenizer (24, 26) including a rectangular opening, a laser beam incident on the inside of which reaching the surface to be irradiated, and wherein the homogenizer (24, 26) divides the laser beam into a plurality of beams with respect to a short-axis direction of the incident region, and superimposes the plurality of divided beams on the surface to be irradiated to cause the superimposed beams to be incident on the incident region, characterized in that the slow-axis direction of the semiconductor laser oscillator is inclined with respect to a long-axis direction of the incident region, wherein at an incident position to the homogenizer (24, 26), a profile of the laser beam shows a maximum value periodically at a pitch P with respect to the fast-axis direction, and when a dimension of a cross-section of the laser beam at the incident position to the homogenizer (24, 26) in the long-axis direction is denoted by L, and an inclined angle between the slow-axis direction of the semiconductor laser oscillator and the long-axis direction is denoted by θ, the inclined angle θ is in a range of 0.5 times to 1.5 times sin -1 (P/L).
A fuel additive cartridge for a vehicle fuel system, comprising: a reservoir for a liquid fuel additive, suitable for use with dimethyl-ether, configured to be attached to a fuel fill conduit; and a dispenser (56; 62, 64; 70) configured to selectively dispense the liquid fuel additive from the reservoir during fueling when fuel is flowing in the fill conduit. a reservoir for a liquid fuel additive, suitable for use with dimethyl-ether, configured to be attached to a fuel fill conduit; and a dispenser (56; 62, 64; 70) configured to selectively dispense the liquid fuel additive from the reservoir during fueling when fuel is flowing in the fill conduit.
A method for controlling a wind turbine, the wind turbine comprising a support structure and at least two energy generating units mounted on the support structure, each energy generating unit comprising a rotor comprising a set of wind turbine blades, the energy generating units being operable within a set of operational constraints, the method comprising the steps of: - obtaining a first operational state of each of the energy generating units, - detecting that a difference in thrust acting on at least two of the energy generating units is present, - adjusting at least one constraint parameter of the set of operational constraints in accordance with prevailing operating conditions and in accordance with the detected difference in thrust, - deriving a new operational state for at least one of the energy generating units, based on the at least one adjusted constraint parameter, the new operational state(s) counteracting the detected difference in thrust, and - controlling the wind turbine in accordance with the new operational states for the energy generating units. - obtaining a first operational state of each of the energy generating units, - detecting that a difference in thrust acting on at least two of the energy generating units is present, - adjusting at least one constraint parameter of the set of operational constraints in accordance with prevailing operating conditions and in accordance with the detected difference in thrust, - deriving a new operational state for at least one of the energy generating units, based on the at least one adjusted constraint parameter, the new operational state(s) counteracting the detected difference in thrust, and - controlling the wind turbine in accordance with the new operational states for the energy generating units.
A mass image processing apparatus comprising: a pre-processor that is configured to apply a pre-process to an original mass image produced through mass spectrometry of a sample, to produce a model input image; a converter that has an image quality conversion model for improving the image quality of the mass image of the sample, said image quality conversion model produced through machine learning based on a group of images produced through sample analysis different from the mass spectrometry, wherein the different sample analysis is sample observation by a scanning electron microscope and said image quality conversion model is configured to produce a model output image through image quality conversion of the model input image; and a post-processor that is configured to apply a post-process to the model output image, to produce a mass image after image quality conversion, wherein the pre-process is a process to fit the model input image with respect to an input condition of the converter, and the post-process is a process to fit the mass image after the image quality conversion with respect to a mass image output condition. a pre-processor that is configured to apply a pre-process to an original mass image produced through mass spectrometry of a sample, to produce a model input image; a converter that has an image quality conversion model for improving the image quality of the mass image of the sample, said image quality conversion model produced through machine learning based on a group of images produced through sample analysis different from the mass spectrometry, wherein the different sample analysis is sample observation by a scanning electron microscope and said image quality conversion model is configured to produce a model output image through image quality conversion of the model input image; and a post-processor that is configured to apply a post-process to the model output image, to produce a mass image after image quality conversion, wherein the pre-process is a process to fit the model input image with respect to an input condition of the converter, and the post-process is a process to fit the mass image after the image quality conversion with respect to a mass image output condition.