An inflatable insulation box comprising a box body and a box lid; wherein the box body has an opening, and the box lid is configured to close the opening of the box body; the box body and the box lid comprise fabrics on outer layers and airbags on inner layers, respectively; and an air valve is provided on the box body and/or the box lid and is configured to inflate or deflate the airbags; wherein the box body comprises a front side face, a rear side face, a left side face, a right side face and a bottom face which are integrally connected to one another; each of the front side face, rear side face, left side face, right side face, bottom face and box lid has a rectangular shape in a plan view; and characterized in that: in an unfolded state: the left side face, the front side face and the right side face are sequentially aligned in a row and the airbags respectively provided on the left side face, the front side face and the right side face all extend parallel to one another, and the front side face, the bottom face, the rear side face, and the box lid are sequentially aligned in a column and the airbags respectively provided on the front side face, the bottom face, the rear side face and the box lid all extend in alignment with one another, the front side face, the rear side face, the left side face, the right side face, the bottom face and the box lid are configured to form the insulation box after being folded the box lid is connected with the rear side face through long sides of the rectangular shapes thereof, the rear side face is connected with the bottom face through long sides of the rectangular shapes thereof, the bottom face is connected with the front side face through long sides of the rectangular shapes thereof, the left side face is connected with the front side face through short sides of the rectangular shapes thereof, and the front side face is connected with the right side face through short sides of the rectangular shapes thereof; and creases are provided between individual faces of the box body and between the box lid and the box body. wherein the box body has an opening, and the box lid is configured to close the opening of the box body; the box body and the box lid comprise fabrics on outer layers and airbags on inner layers, respectively; and an air valve is provided on the box body and/or the box lid and is configured to inflate or deflate the airbags; wherein the box body comprises a front side face, a rear side face, a left side face, a right side face and a bottom face which are integrally connected to one another; each of the front side face, rear side face, left side face, right side face, bottom face and box lid has a rectangular shape in a plan view; and characterized in that: in an unfolded state: the left side face, the front side face and the right side face are sequentially aligned in a row and the airbags respectively provided on the left side face, the front side face and the right side face all extend parallel to one another, and the front side face, the bottom face, the rear side face, and the box lid are sequentially aligned in a column and the airbags respectively provided on the front side face, the bottom face, the rear side face and the box lid all extend in alignment with one another, the front side face, the rear side face, the left side face, the right side face, the bottom face and the box lid are configured to form the insulation box after being folded the box lid is connected with the rear side face through long sides of the rectangular shapes thereof, the rear side face is connected with the bottom face through long sides of the rectangular shapes thereof, the bottom face is connected with the front side face through long sides of the rectangular shapes thereof, the left side face is connected with the front side face through short sides of the rectangular shapes thereof, and the front side face is connected with the right side face through short sides of the rectangular shapes thereof; and creases are provided between individual faces of the box body and between the box lid and the box body. the left side face, the front side face and the right side face are sequentially aligned in a row and the airbags respectively provided on the left side face, the front side face and the right side face all extend parallel to one another, and the front side face, the bottom face, the rear side face, and the box lid are sequentially aligned in a column and the airbags respectively provided on the front side face, the bottom face, the rear side face and the box lid all extend in alignment with one another, the front side face, the rear side face, the left side face, the right side face, the bottom face and the box lid are configured to form the insulation box after being folded the box lid is connected with the rear side face through long sides of the rectangular shapes thereof, the rear side face is connected with the bottom face through long sides of the rectangular shapes thereof, the bottom face is connected with the front side face through long sides of the rectangular shapes thereof, the left side face is connected with the front side face through short sides of the rectangular shapes thereof, and the front side face is connected with the right side face through short sides of the rectangular shapes thereof; and creases are provided between individual faces of the box body and between the box lid and the box body.