A system for controlling delivery of electrostimulation to specific tissue of a patient, the system comprising: a receiver circuit configured to receive a three-dimensional voxelized model of tissue representing a plurality of regions each specified as a target region or an avoidance region; control circuitry, including a stimulation programmer circuit configured to: determine a metric value using the 3D voxelized model, the metric value indicative of a clinical effect of electrostimulation on the plurality of regions according to a stimulation current and a current fractionalization across a plurality of electrodes; determine a first stimulation current that results in a first metric value satisfying a clinical effect condition, the first metric value associated with a corresponding electrode current fractionalization; and generate a stimulation configuration for tissue stimulation, the stimulation configuration including the first stimulation current and the current fractionalization corresponding to the first metric value; and an implantable stimulator and an external programming device configured to be communicatively coupled to the implantable stimulator, wherein: the implantable stimulator includes an electrostimulation generator circuit configured to generate stimulation energy for delivery to the tissue according to the generated stimulation configuration; and the external programming device includes the receiver circuit and the control circuitry, wherein the stimulation programmer circuit is configured to generate the stimulation configuration including searching for a desired stimulation location with respect to positions of the plurality of electrodes, wherein the desired stimulation location is represented by at least a longitudinal coordinate and an angular coordinate in a coordinate space, and corresponds to the first metric value and its associated stimulation current. a receiver circuit configured to receive a three-dimensional voxelized model of tissue representing a plurality of regions each specified as a target region or an avoidance region; control circuitry, including a stimulation programmer circuit configured to: determine a metric value using the 3D voxelized model, the metric value indicative of a clinical effect of electrostimulation on the plurality of regions according to a stimulation current and a current fractionalization across a plurality of electrodes; determine a first stimulation current that results in a first metric value satisfying a clinical effect condition, the first metric value associated with a corresponding electrode current fractionalization; and generate a stimulation configuration for tissue stimulation, the stimulation configuration including the first stimulation current and the current fractionalization corresponding to the first metric value; and determine a metric value using the 3D voxelized model, the metric value indicative of a clinical effect of electrostimulation on the plurality of regions according to a stimulation current and a current fractionalization across a plurality of electrodes; determine a first stimulation current that results in a first metric value satisfying a clinical effect condition, the first metric value associated with a corresponding electrode current fractionalization; and generate a stimulation configuration for tissue stimulation, the stimulation configuration including the first stimulation current and the current fractionalization corresponding to the first metric value; and an implantable stimulator and an external programming device configured to be communicatively coupled to the implantable stimulator, wherein: the implantable stimulator includes an electrostimulation generator circuit configured to generate stimulation energy for delivery to the tissue according to the generated stimulation configuration; and the external programming device includes the receiver circuit and the control circuitry, wherein the stimulation programmer circuit is configured to generate the stimulation configuration including searching for a desired stimulation location with respect to positions of the plurality of electrodes, wherein the desired stimulation location is represented by at least a longitudinal coordinate and an angular coordinate in a coordinate space, and corresponds to the first metric value and its associated stimulation current. the implantable stimulator includes an electrostimulation generator circuit configured to generate stimulation energy for delivery to the tissue according to the generated stimulation configuration; and the external programming device includes the receiver circuit and the control circuitry, wherein the stimulation programmer circuit is configured to generate the stimulation configuration including searching for a desired stimulation location with respect to positions of the plurality of electrodes, wherein the desired stimulation location is represented by at least a longitudinal coordinate and an angular coordinate in a coordinate space, and corresponds to the first metric value and its associated stimulation current.