A compound of formula IA: wherein: R 1 is a 5-11 membered heteroaryl ring containing one to three heteroatoms selected from nitrogen, oxygen and sulfur, wherein the heteroaryl ring is optionally independently substituted with one to three groups selected from Ra, Rb and Rc; R 2 is C 1 -C 6 alkyl; R 3 is -OH, -N(R 8)(R 9), -NH-S 2 -C 1-6 alkyl, NH-S 2 -aryl, 5-6 membered heterocycle or C 1-6 alkoxy; R 4, R 5, R 6 and R 7 are each independently selected from (a) -H, (b) -OH, (c) halogen, (d) -CN, (e) -CF 3, (f) C 1-6 alkyl optionally substituted with one to three -OH, fluorine, C 1-6 alkoxyl, -N(R 8)(R 9), or -C N(R 8)(R 9), (g) C 1-6 alkoxy optionally substituted with one to three -OH, fluorine, -OC 1 - 6 alkyl, or -OC 3 - 6 cycloalkyl, (h) -S n C 1-6 alkyl, (i) -CO 2 R 8, (j) -S 2 N(R 8)(R 9), (k) a 5-membered heteroaryl ring, (l) a 5-6 membered heterocyclic ring; R 8 and R 9 are each independently selected from -H, C 1-6 alkyl, C 3-6 cycloalkyl, halogen, -CF 3, -OH, -(CH 2) n CO 2 R 10, -CN, C 1-6 alkoxyl, C 1-6 alkyl-O- C 1-3 alkyl, C 1-6 alkylhydroxyl, C 1-3 alkyl-CN, 5-6 membered heteroaryl ring and 5-6 membered heterocyclic ring, wherein the C 1-6 alkyl is optionally substituted with a 5-6 heteroaryl ring, 5-6 membered heterocyclic ring or -N(R 10)(R 11); R 10 and R 11 are each independently selected from -H and C 1-6 alkyl; Ra is selected from H, -NH 2, -NH(C 1 -C 6)alkyl, -NR 10 R 11, -NH-C C 1 -C 6 alkyl, NR"-C C 1 -C 6 alkyl, -O(C 1 -C 8)alkyl, -O(C 3 -C 6)cycloalkyl, -S-(C 1 -C 6)alkyl, -S -C 1 -C 6 alkyl, -S 2 -C 1 -C 6 alkyl, oxo and -CH 2 -OH; Rb is selected from -H, -(C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -NH 2, -CH 2 -OH, -C≡N, -CH 2 NH 2 and -C OCH 3; Rc is selected from -H, -CH 3 and, -OH; n is 1 or 2; or a pharmaceutically acceptable salt thereof; with the proviso that the compounds and are excluded. R 1 is a 5-11 membered heteroaryl ring containing one to three heteroatoms selected from nitrogen, oxygen and sulfur, wherein the heteroaryl ring is optionally independently substituted with one to three groups selected from Ra, Rb and Rc; R 2 is C 1 -C 6 alkyl; R 3 is -OH, -N(R 8)(R 9), -NH-S 2 -C 1-6 alkyl, NH-S 2 -aryl, 5-6 membered heterocycle or C 1-6 alkoxy; R 4, R 5, R 6 and R 7 are each independently selected from (a) -H, (b) -OH, (c) halogen, (d) -CN, (e) -CF 3, (f) C 1-6 alkyl optionally substituted with one to three -OH, fluorine, C 1-6 alkoxyl, -N(R 8)(R 9), or -C N(R 8)(R 9), (g) C 1-6 alkoxy optionally substituted with one to three -OH, fluorine, -OC 1 - 6 alkyl, or -OC 3 - 6 cycloalkyl, (h) -S n C 1-6 alkyl, (i) -CO 2 R 8, (j) -S 2 N(R 8)(R 9), (k) a 5-membered heteroaryl ring, (l) a 5-6 membered heterocyclic ring; (a) -H, (b) -OH, (c) halogen, (d) -CN, (e) -CF 3, (f) C 1-6 alkyl optionally substituted with one to three -OH, fluorine, C 1-6 alkoxyl, -N(R 8)(R 9), or -C N(R 8)(R 9), (g) C 1-6 alkoxy optionally substituted with one to three -OH, fluorine, -OC 1 - 6 alkyl, or -OC 3 - 6 cycloalkyl, (h) -S n C 1-6 alkyl, (i) -CO 2 R 8, (j) -S 2 N(R 8)(R 9), (k) a 5-membered heteroaryl ring, (l) a 5-6 membered heterocyclic ring; R 8 and R 9 are each independently selected from -H, C 1-6 alkyl, C 3-6 cycloalkyl, halogen, -CF 3, -OH, -(CH 2) n CO 2 R 10, -CN, C 1-6 alkoxyl, C 1-6 alkyl-O- C 1-3 alkyl, C 1-6 alkylhydroxyl, C 1-3 alkyl-CN, 5-6 membered heteroaryl ring and 5-6 membered heterocyclic ring, wherein the C 1-6 alkyl is optionally substituted with a 5-6 heteroaryl ring, 5-6 membered heterocyclic ring or -N(R 10)(R 11); R 10 and R 11 are each independently selected from -H and C 1-6 alkyl; Ra is selected from H, -NH 2, -NH(C 1 -C 6)alkyl, -NR 10 R 11, -NH-C C 1 -C 6 alkyl, NR"-C C 1 -C 6 alkyl, -O(C 1 -C 8)alkyl, -O(C 3 -C 6)cycloalkyl, -S-(C 1 -C 6)alkyl, -S -C 1 -C 6 alkyl, -S 2 -C 1 -C 6 alkyl, oxo and -CH 2 -OH; Rb is selected from -H, -(C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -NH 2, -CH 2 -OH, -C≡N, -CH 2 NH 2 and -C OCH 3; Rc is selected from -H, -CH 3 and, -OH; n is 1 or 2;