A compound of Formula or its stereoisomers or tautomers, or pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, wherein R 1 is H, LA, Hal, CN, S, CA, R 2 is H, NH 2, LA, NH, Hal, X-Cyc, R 3 is LA, Hal, CN, CONH 2, CONH, or R 2, R 3 together with the C atom they are attached to, form a 5 or 6 membered aliphatic heterocycle, having 1-3 heteroatoms, selected from O, S and N, which is substituted by 1 or 2 oxo groups, which heterocycle may further be monosubstituted by LA, and which heterocycle may form a condensed ring system with a phenyl or pyridyl group, R 4 is H, LA, CONH or X-Cyc, R 5 is H, F, or R 4, R 5 together with the atoms they are attached to, form a 5 or 6 membered heterocycle, having 1-3 heteroatoms, selected from O, S and N, which is, optionally, independently mono-, di- or trisubstituted by oxo, LA, NH 2, NH, N 2, HO -, or which is, optionally, monosubsituted by CA, R 6 is H, LA, OH or F, Cyc is a 5 or 6 membered monocyclic, aliphatic or aromatic homo- or heterocycle having 1-3 heteroatoms, selected from O, S and N, which may be mono- or di-substituted by oxo, LA, NH 2, NH, N 2, HO -, or monosubstituted by CA, X is -CH 2 -, -C 2 H 4 -, -NH-, -O-, or a bond, LA is unbranched or branched alkyl, having 1, 2, 3, 4 or 5 carbon atoms, which may be saturated or partially unsaturated, wherein 1, 2 or 3 H atoms may be replaced by Hal, and/or 1 CH 2 group may be replaced by -O-, -NH- or -SO 2 -, and/or 1 CH group may be replaced by N, CA is cycloalkyl having 3, 4, 5 or 6 carbon atoms, or cycloalkyl alkyl having 3, 4, 5 or 6 ring carbon atoms and 1 or 2 non-ring carbon atoms, in which cycloalkyl, or cycloalkyl alkyl, 1 CH 2 group may be replaced by -O-, or 1 CH group may be replaced by N, and Hal is F, Cl, Br or I. R 1 is H, LA, Hal, CN, S, CA, R 2 is H, NH 2, LA, NH, Hal, X-Cyc, R 3 is LA, Hal, CN, CONH 2, CONH, or R 2, R 3 together with the C atom they are attached to, form a 5 or 6 membered aliphatic heterocycle, having 1-3 heteroatoms, selected from O, S and N, which is substituted by 1 or 2 oxo groups, which heterocycle may further be monosubstituted by LA, and which heterocycle may form a condensed ring system with a phenyl or pyridyl group, R 4 is H, LA, CONH or X-Cyc, R 5 is H, F, or R 4, R 5 together with the atoms they are attached to, form a 5 or 6 membered heterocycle, having 1-3 heteroatoms, selected from O, S and N, which is, optionally, independently mono-, di- or trisubstituted by oxo, LA, NH 2, NH, N 2, HO -, or which is, optionally, monosubsituted by CA, R 6 is H, LA, OH or F, Cyc is a 5 or 6 membered monocyclic, aliphatic or aromatic homo- or heterocycle having 1-3 heteroatoms, selected from O, S and N, which may be mono- or di-substituted by oxo, LA, NH 2, NH, N 2, HO -, or monosubstituted by CA, X is -CH 2 -, -C 2 H 4 -, -NH-, -O-, or a bond, LA is unbranched or branched alkyl, having 1, 2, 3, 4 or 5 carbon atoms, which may be saturated or partially unsaturated, wherein 1, 2 or 3 H atoms may be replaced by Hal, and/or 1 CH 2 group may be replaced by -O-, -NH- or -SO 2 -, and/or 1 CH group may be replaced by N, CA is cycloalkyl having 3, 4, 5 or 6 carbon atoms, or cycloalkyl alkyl having 3, 4, 5 or 6 ring carbon atoms and 1 or 2 non-ring carbon atoms, in which cycloalkyl, or cycloalkyl alkyl, 1 CH 2 group may be replaced by -O-, or 1 CH group may be replaced by N, and Hal is F, Cl, Br or I.