A composition comprising (i) particles contained in a liquid phase, wherein the particles comprise RNA and a lipid composition, and wherein the lipid composition comprises: (i-a) a cholesterol derivative of formula or a salt thereof: wherein n is 0 or 1, preferably 0, R 1 is a group -(CH 2) q -NH 2 or a group -(CH 2) r -NH-(CH 2) s -NH 2, wherein q, r and s are independently an integer of 2 to 6, R 2 is a group -(CH 2) t -NH 2 or a group -(CH 2) u -NH-(CH 2) w -NH 2, wherein t, u and w are independently an integer of 2 to 6, R 3 is a linear alkanediyl group having 1 to 4 carbon atoms; (i-b) a phosphoglyceride of formula or a salt thereof: wherein R 4 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; R 5 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; and (i-c) a pegylated phosphoglyceride of formula or a salt thereof: wherein p is an integer of 5 to 200, preferably 10 to 170 and most preferably 10 to 140 R 6 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; R 7 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; and (ii) 1,2-propanediol. (i) particles contained in a liquid phase, wherein the particles comprise RNA and a lipid composition, and wherein the lipid composition comprises: (i-a) a cholesterol derivative of formula or a salt thereof: wherein n is 0 or 1, preferably 0, R 1 is a group -(CH 2) q -NH 2 or a group -(CH 2) r -NH-(CH 2) s -NH 2, wherein q, r and s are independently an integer of 2 to 6, R 2 is a group -(CH 2) t -NH 2 or a group -(CH 2) u -NH-(CH 2) w -NH 2, wherein t, u and w are independently an integer of 2 to 6, R 3 is a linear alkanediyl group having 1 to 4 carbon atoms; (i-b) a phosphoglyceride of formula or a salt thereof: wherein R 4 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; R 5 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; and (i-c) a pegylated phosphoglyceride of formula or a salt thereof: wherein p is an integer of 5 to 200, preferably 10 to 170 and most preferably 10 to 140 R 6 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; R 7 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; and (i-a) a cholesterol derivative of formula or a salt thereof: wherein n is 0 or 1, preferably 0, R 1 is a group -(CH 2) q -NH 2 or a group -(CH 2) r -NH-(CH 2) s -NH 2, wherein q, r and s are independently an integer of 2 to 6, R 2 is a group -(CH 2) t -NH 2 or a group -(CH 2) u -NH-(CH 2) w -NH 2, wherein t, u and w are independently an integer of 2 to 6, R 3 is a linear alkanediyl group having 1 to 4 carbon atoms; n is 0 or 1, preferably 0, R 1 is a group -(CH 2) q -NH 2 or a group -(CH 2) r -NH-(CH 2) s -NH 2, wherein q, r and s are independently an integer of 2 to 6, R 2 is a group -(CH 2) t -NH 2 or a group -(CH 2) u -NH-(CH 2) w -NH 2, wherein t, u and w are independently an integer of 2 to 6, R 3 is a linear alkanediyl group having 1 to 4 carbon atoms; (i-b) a phosphoglyceride of formula or a salt thereof: wherein R 4 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; R 5 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; and R 4 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; R 5 is a linear alkyl group having 10 to 24 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 24 carbon atoms; and (i-c) a pegylated phosphoglyceride of formula or a salt thereof: wherein p is an integer of 5 to 200, preferably 10 to 170 and most preferably 10 to 140 R 6 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; R 7 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; and p is an integer of 5 to 200, preferably 10 to 170 and most preferably 10 to 140 R 6 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; R 7 is a linear alkyl group having 10 to 20 carbon atoms or a linear alkenyl group having 1 to 3 double bonds and 10 to 20 carbon atoms; (ii) 1,2-propanediol.