A method of evaluating a vessel of a patient, comprising: outputting, to a touch-sensitive display of a bedside controller, a screen display including: a first proximal pressure waveform and a first distal pressure waveform (1252, 1256) of pressure measurements obtained by first and second instruments (830, 832) positioned within a vessel while the second instrument is moved longitudinally through the vessel from a first position distal of a stenosis of the vessel to a second position proximal of the stenosis and the first instrument remains stationary within the vessel; a second proximal pressure waveform and a second distal pressure waveform of the obtained pressure measurements, wherein the second proximal and distal pressure waveforms illustrate the obtained pressure measurements over a greater amount of time compared to the first proximal and distal pressure waveforms (1252, 1256); and an overlay positioned over a portion of the second proximal and distal pressure waveforms, the overlay illustrating a portion of the obtained pressure measurement represented in the first proximal and distal pressure waveforms (1252, 1256); receiving, through the touch-sensitive display of the bedside controller, a user touch input on at least one of the first proximal pressure waveform and the first distal pressure waveform (1252, 1256) identifying a time at which pressure measurements were obtained; modifying the screen display, in response to the user touch input, to further include a visual representation of the obtained pressure measurements corresponding to the identified time, and wherein the visual representation is displayed at a location proximate the at least a portion of the first pressure waveform defined by a point of initial contact with the touch-sensitive display; receiving, through the touch-sensitive display of the bedside controller, a user touch input on the overlay to move the overlay to be positioned over a different portion of the second proximal and distal pressure waveforms; and modifying the screen display, in response to the user touch input, such that the at least a portion of the first proximal and distal pressure waveforms (1252, 1256) include the obtained pressure measurements corresponding to the position of the overlay over the different portion of the second proximal and distal pressure waveforms. outputting, to a touch-sensitive display of a bedside controller, a screen display including: a first proximal pressure waveform and a first distal pressure waveform (1252, 1256) of pressure measurements obtained by first and second instruments (830, 832) positioned within a vessel while the second instrument is moved longitudinally through the vessel from a first position distal of a stenosis of the vessel to a second position proximal of the stenosis and the first instrument remains stationary within the vessel; a second proximal pressure waveform and a second distal pressure waveform of the obtained pressure measurements, wherein the second proximal and distal pressure waveforms illustrate the obtained pressure measurements over a greater amount of time compared to the first proximal and distal pressure waveforms (1252, 1256); and an overlay positioned over a portion of the second proximal and distal pressure waveforms, the overlay illustrating a portion of the obtained pressure measurement represented in the first proximal and distal pressure waveforms (1252, 1256); a first proximal pressure waveform and a first distal pressure waveform (1252, 1256) of pressure measurements obtained by first and second instruments (830, 832) positioned within a vessel while the second instrument is moved longitudinally through the vessel from a first position distal of a stenosis of the vessel to a second position proximal of the stenosis and the first instrument remains stationary within the vessel; a second proximal pressure waveform and a second distal pressure waveform of the obtained pressure measurements, wherein the second proximal and distal pressure waveforms illustrate the obtained pressure measurements over a greater amount of time compared to the first proximal and distal pressure waveforms (1252, 1256); and an overlay positioned over a portion of the second proximal and distal pressure waveforms, the overlay illustrating a portion of the obtained pressure measurement represented in the first proximal and distal pressure waveforms (1252, 1256); receiving, through the touch-sensitive display of the bedside controller, a user touch input on at least one of the first proximal pressure waveform and the first distal pressure waveform (1252, 1256) identifying a time at which pressure measurements were obtained; modifying the screen display, in response to the user touch input, to further include a visual representation of the obtained pressure measurements corresponding to the identified time, and wherein the visual representation is displayed at a location proximate the at least a portion of the first pressure waveform defined by a point of initial contact with the touch-sensitive display; receiving, through the touch-sensitive display of the bedside controller, a user touch input on the overlay to move the overlay to be positioned over a different portion of the second proximal and distal pressure waveforms; and modifying the screen display, in response to the user touch input, such that the at least a portion of the first proximal and distal pressure waveforms (1252, 1256) include the obtained pressure measurements corresponding to the position of the overlay over the different portion of the second proximal and distal pressure waveforms.