A surgical instrument, comprising: a housing including a first actuator, a second actuator and a third actuator; an elongated portion extending distally from the housing and defining a longitudinal axis; an end effector disposed adjacent a distal portion of the elongated portion, the end effector including a first jaw member and a second jaw member, the first jaw member having a cavity defined therein, the first jaw member movable relative to the second jaw member between an open position and an approximated position, wherein the first jaw member applies a first force against tissue disposed between the jaw members; a drive beam disposed in mechanical cooperation with the first actuator, the first actuator selectively and independently actuatable with respect to the second and third actuator, wherein at least a partial actuation of the first actuator causes distal translation of the drive beam to move the first jaw member relative to the second jaw member toward the approximated position; a force applier disposed in mechanical cooperation with the second actuator, the second actuator selectively and independently actuatable with respect to the first and third actuator, wherein at least a partial actuation of the second actuator causes distal translation of the force applier such that at least a portion of the force applier moves into the cavity of the first jaw member and applies an additional force against tissue disposed between the jaw members; and a knife assembly, wherein the third actuator is disposed in mechanical cooperation with the housing, and wherein the knife assembly is in mechanical cooperation with the third actuator, the third actuator selectively and independently actuatable with respect to the first actuator and the second actuator, wherein at least a partial actuation of the third actuator causes distal translation of the knife assembly. a housing including a first actuator, a second actuator and a third actuator; an elongated portion extending distally from the housing and defining a longitudinal axis; an end effector disposed adjacent a distal portion of the elongated portion, the end effector including a first jaw member and a second jaw member, the first jaw member having a cavity defined therein, the first jaw member movable relative to the second jaw member between an open position and an approximated position, wherein the first jaw member applies a first force against tissue disposed between the jaw members; a drive beam disposed in mechanical cooperation with the first actuator, the first actuator selectively and independently actuatable with respect to the second and third actuator, wherein at least a partial actuation of the first actuator causes distal translation of the drive beam to move the first jaw member relative to the second jaw member toward the approximated position; a force applier disposed in mechanical cooperation with the second actuator, the second actuator selectively and independently actuatable with respect to the first and third actuator, wherein at least a partial actuation of the second actuator causes distal translation of the force applier such that at least a portion of the force applier moves into the cavity of the first jaw member and applies an additional force against tissue disposed between the jaw members; and a knife assembly, wherein the third actuator is disposed in mechanical cooperation with the housing, and wherein the knife assembly is in mechanical cooperation with the third actuator, the third actuator selectively and independently actuatable with respect to the first actuator and the second actuator, wherein at least a partial actuation of the third actuator causes distal translation of the knife assembly.