A compound of formula I: or a pharmaceutically acceptable salt, deuterated analog, stereoisomer, or a mixture of stereoisomers thereof, wherein: R 1 is optionally substituted C 3-6 cycloalkyl; R 2 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 1-6 alkoxy, optionally substituted C 3-6 cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or -C N(R 11)(R 12); R 3 is optionally substituted C 1-6 alkoxy, optionally substituted C 3-6 cycloalkyl, optionally substituted C 3-6 cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, or -N(R 11); R 4 is hydrogen or halo; R 5 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or - C N(R 11)(R 12); each R 10 is independently optionally substituted C 1-6 alkyl or optionally substituted C 1-6 alkoxy; and R 11 and R 12 are each independently hydrogen, optionally substituted C 1-6 alkyl, or optionally substituted C 3-6 cycloalkyl; wherein "substituted" means at least one hydrogen atom is replaced by a bond to alkyl, alkenyl, alkynyl, alkoxy, alkylthio, acyl, amido, amino, amidino, aryl, aralkyl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, guanadino, halo, haloalkyl, haloalkoxy, hydroxyalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydrazine, hydrazone, imino, imido, hydroxy, oxo, oxime, nitro, sulfonyl, sulfinyl, alkylsulfonyl, alkylsulfinyl, thiocyanate, sulfinic acid, sulfonic acid, sulfonamido, thiol, thioxo, N-oxide, or -Si(R y) 3 wherein each R y is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, C 3-6 cycloalkyl, aryl, heteroaryl, or heterocyclyl. R 1 is optionally substituted C 3-6 cycloalkyl; R 2 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted C 1-6 alkoxy, optionally substituted C 3-6 cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or -C N(R 11)(R 12); R 3 is optionally substituted C 1-6 alkoxy, optionally substituted C 3-6 cycloalkyl, optionally substituted C 3-6 cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, or -N(R 11); R 4 is hydrogen or halo; R 5 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 3-6 cycloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or - C N(R 11)(R 12); each R 10 is independently optionally substituted C 1-6 alkyl or optionally substituted C 1-6 alkoxy; and R 11 and R 12 are each independently hydrogen, optionally substituted C 1-6 alkyl, or optionally substituted C 3-6 cycloalkyl; wherein "substituted" means at least one hydrogen atom is replaced by a bond to alkyl, alkenyl, alkynyl, alkoxy, alkylthio, acyl, amido, amino, amidino, aryl, aralkyl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, guanadino, halo, haloalkyl, haloalkoxy, hydroxyalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydrazine, hydrazone, imino, imido, hydroxy, oxo, oxime, nitro, sulfonyl, sulfinyl, alkylsulfonyl, alkylsulfinyl, thiocyanate, sulfinic acid, sulfonic acid, sulfonamido, thiol, thioxo, N-oxide, or -Si(R y) 3 wherein each R y is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, C 3-6 cycloalkyl, aryl, heteroaryl, or heterocyclyl.