Method for improving pacing settings of a pace maker, comprising, by means of a processing unit: a) receiving a set of pacing settings for the pace maker; characterised in that the method further comprises: b) receiving measurements or fluid mechanics data relating to the heart of a subject for all or part of the pacing settings of the set; c) estimating hemodynamic force parameters by elaborating such measurements or input hemodynamic forces parameters as received; d) selecting an optimal pacing setting of the set, or calculating further pace settings, based on the hemodynamic forces parameters as estimated; wherein step b) and step c) are executed as one or more of: step b) comprising providing pressure information of a plurality of points in the left ventricle of the subject, and step c) comprising transforming the pressure information into a pressure difference or gradient field inside the left ventricle; step b) comprising providing acceleration or position information of a plurality of points in the left ventricle of the subject, and step c) comprising transforming the acceleration/position information into velocity information by time integration/derivation and evaluating pressure gradients from such velocities by integrating the Navier Stokes equation; step b) comprising providing the velocity at a plurality of points inside the cardiac chamber and step c) comprising evaluating pressure gradients from such velocities by integrating the Navier Stokes equation; step b) comprising providing bi-dimensional or tri-dimensional Doppler ultrasound information of the left ventricle of the subject, and step c) comprising transforming the Doppler ultrasound information into a multidimensional velocity field and calculating from the multidimensional velocity field a pressure gradient field inside the left ventricle; step b) comprising providing the dynamics of the endocardial border and flux of momentum across the mitral and aortic valves of the subject, and step c) comprising calculating hemodynamic forces as those required to balance the flux of momentum across the mitral and aortic valves and the force absorbed by the myocardium. a) receiving a set of pacing settings for the pace maker; characterised in that the method further comprises: b) receiving measurements or fluid mechanics data relating to the heart of a subject for all or part of the pacing settings of the set; c) estimating hemodynamic force parameters by elaborating such measurements or input hemodynamic forces parameters as received; d) selecting an optimal pacing setting of the set, or calculating further pace settings, based on the hemodynamic forces parameters as estimated; step b) comprising providing pressure information of a plurality of points in the left ventricle of the subject, and step c) comprising transforming the pressure information into a pressure difference or gradient field inside the left ventricle; step b) comprising providing acceleration or position information of a plurality of points in the left ventricle of the subject, and step c) comprising transforming the acceleration/position information into velocity information by time integration/derivation and evaluating pressure gradients from such velocities by integrating the Navier Stokes equation; step b) comprising providing the velocity at a plurality of points inside the cardiac chamber and step c) comprising evaluating pressure gradients from such velocities by integrating the Navier Stokes equation; step b) comprising providing bi-dimensional or tri-dimensional Doppler ultrasound information of the left ventricle of the subject, and step c) comprising transforming the Doppler ultrasound information into a multidimensional velocity field and calculating from the multidimensional velocity field a pressure gradient field inside the left ventricle; step b) comprising providing the dynamics of the endocardial border and flux of momentum across the mitral and aortic valves of the subject, and step c) comprising calculating hemodynamic forces as those required to balance the flux of momentum across the mitral and aortic valves and the force absorbed by the myocardium.