A three dimensional orientation configuration apparatus comprising: a projection image generation unit that generates a two-dimensional projection image from a three dimensional image indicating a three dimensional structure including a three-dimensional object; an input unit that receives the designation of a two-dimensional target point which is a target point on the projection image; a three dimensional target point setting unit that sets as a three dimensional target point an intersection point of the three dimensional structure included in the three dimensional image and a projection line which extends from a point of view, the three dimensional target point corresponding to the two-dimensional target point to the three dimensional image; a reference cross-section setting unit that sets a reference cross-section to the three dimensional image on the basis of the three dimensional target point; a cross-sectional two-dimensional image generation unit that generates a cross-sectional two-dimensional image of the reference cross-section in which the object closer to a point of view, the point of view is located on a line that passes through the three dimensional target point and the line is perpendicular to the reference cross-section and the point of view faces the reference cross-section, than to the reference cross-section included in the three dimensional image is not displayed; a display unit that displays the cross-sectional two-dimensional image; and a direction determination unit that generates the projection image, displays the projection image, receives the designation of the two-dimensional target point, sets the three dimensional target point, sets the reference cross-section, generates the cross-sectional two-dimensional image, displays the cross-sectional two-dimensional image, receives an instruction input by the operator to change the position of a point of view, using the three dimensional target point based on the cross-sectional two-dimensional image as a reference point, in order to align an observation direction of a structure to which the three dimensional target point is set with a target three dimensional direction, sets a new reference cross-section on the basis of the changed position of the point of view, such that said new reference cross-section is rotated about the three dimensional target point, generates a new cross-sectional two-dimensional image of the new reference cross-section, and displays the new cross-sectional two-dimensional Main Request image to determine a three dimensional direction for observing the three dimensional image. a projection image generation unit that generates a two-dimensional projection image from a three dimensional image indicating a three dimensional structure including a three-dimensional object; an input unit that receives the designation of a two-dimensional target point which is a target point on the projection image; a three dimensional target point setting unit that sets as a three dimensional target point an intersection point of the three dimensional structure included in the three dimensional image and a projection line which extends from a point of view, the three dimensional target point corresponding to the two-dimensional target point to the three dimensional image; a reference cross-section setting unit that sets a reference cross-section to the three dimensional image on the basis of the three dimensional target point; a cross-sectional two-dimensional image generation unit that generates a cross-sectional two-dimensional image of the reference cross-section in which the object closer to a point of view, the point of view is located on a line that passes through the three dimensional target point and the line is perpendicular to the reference cross-section and the point of view faces the reference cross-section, than to the reference cross-section included in the three dimensional image is not displayed; a display unit that displays the cross-sectional two-dimensional image; and a direction determination unit that generates the projection image, displays the projection image, receives the designation of the two-dimensional target point, sets the three dimensional target point, sets the reference cross-section, generates the cross-sectional two-dimensional image, displays the cross-sectional two-dimensional image, receives an instruction input by the operator to change the position of a point of view, using the three dimensional target point based on the cross-sectional two-dimensional image as a reference point, in order to align an observation direction of a structure to which the three dimensional target point is set with a target three dimensional direction, sets a new reference cross-section on the basis of the changed position of the point of view, such that said new reference cross-section is rotated about the three dimensional target point, generates a new cross-sectional two-dimensional image of the new reference cross-section, and displays the new cross-sectional two-dimensional Main Request image to determine a three dimensional direction for observing the three dimensional image.