mhurhangee/ep-ind-claims huggingface dataset:
A container comprising a canister sealed with a metering valve, having a metering chamber, which contains a pharmaceutical aerosol formulation consisting essentially of particulate salmeterol xinafoate optionally in combination with another drug useful in inhalation therapy, suspended in a liquefied propellant gas comprising 1,1,1,2,3,3,3-heptafluoro-n-propane, 1,1,1,2-tetrafluoroethane or a mixture thereof; wherein the formulation contains less than 0.01% of surfactant based on weight of medicament and contains less than 0.01% of components having polarity higher than the liquefied propellant gas based on weight of medicament; said valve characterised in that it contains one or more sealing gaskets composed of greater than 90% of a polymer of ethylene propylene diene monomer (EPDM) and the metering chamber surface presents a substantially fluorinated surface to the formulation. particulate salmeterol xinafoate optionally in combination with another drug useful in inhalation therapy, suspended in a liquefied propellant gas comprising 1,1,1,2,3,3,3-heptafluoro-n-propane, 1,1,1,2-tetrafluoroethane or a mixture thereof;
A vacuumed material collection station for receiving vacuumed material from a vacuum cleaning apparatus, wherein the vacuumed material collection station comprises a vacuumed material collection container and an interface for connecting the vacuum cleaning apparatus to the vacuumed material collection station, wherein the vacuumed material collection station comprises a receptacle space for receiving a filter chamber of a vacuum cleaning apparatus connected to the vacuumed material collection station and a feed device for feeding the filter chamber into the receptacle space, wherein the receptacle space is designed for completely encompassing the filter chamber and/or at the most not encompassing a chamber side facing the interface with the vacuum cleaning apparatus, wherein the receptacle space forms a partial volume within the housing of the vacuumed material collection station, characterized in that the vacuumed material collection station has, in addition to the receptacle space, the vacuumed material collection container which serves to receive suction material from the filter chamber received in the receptacle space and wherein the feed device is designed for removing the filter chamber from the vacuum cleaning apparatus and displacing the filter chamber into the receptacle space.
An isolated TAFA4 protein or agonist thereof, for use as an active ingredient for preventing or treating pain in a subject, wherein said protein comprises the amino acid sequence of SEQ ID NO: 1 or 2 or a sequence having at least 90% identity to SEQ ID NO: 1 or 2; and wherein said agonist is a peptide comprising less than 60 amino acid residues and at least 10 consecutive amino acid residues of SEQ ID NO: 1 or 2, preferably at least 20, 25, 27 or 30 consecutive amino acid residues.
A system, comprising: a multi-stage turbine comprising a shaft and further comprising: an interstage seal extending axially between a first turbine stage and a second turbine stage, wherein the interstage seal comprises: an upper body extending from an upstream seating arm to a downstream seating arm, wherein the upstream and downstream seating arms (64,66) are configured to constrain movement of the interstage seal along a radial direction of the multi-stage turbine; and a lower body extending axially from an upstream end to a downstream end, characterized in that one of the upstream end and the downstream end of the lower body is a seating end and the other one of the upstream end and the downstream end of the lower body is a hook end, wherein the seating end is configured to constrain movement of the interstage seal along the radial direction, and the hook end comprises a protrusion extending crosswise relative to a base of the lower body, wherein the hook end is configured to constrain movement of the interstage seal along the radial direction and an axial direction of the multi-stage turbine, and further in that the upstream seating arm of the upper body is constrained radially towards the shaft by an upper support extending axially from a first bucket of the first turbine stage while being axially unconstrained, the seating end of the lower body is constrained radially away from the shaft by a lower support extending axially from a first rotor wheel of the first turbine stage while being axially unconstrained, the downstream seating arm of the upper body is constrained radially towards the shaft by an upper support extending axially from a second bucket of the second turbine stage while being axially unconstrained, and the hook end of the lower body is constrained radially by a lower support extending axially from a second rotor wheel of the second turbine stage. an upper body extending from an upstream seating arm to a downstream seating arm, wherein the upstream and downstream seating arms (64,66) are configured to constrain movement of the interstage seal along a radial direction of the multi-stage turbine; and a lower body extending axially from an upstream end to a downstream end, characterized in that
Actuating device for a steady rest, for supporting and/or clamping of a workpiece, with a carrier having an attachment side which is configured for attachment of the steady rest, with an actuating part which is mounted on the carrier so as to be movable in the height direction, and at an outer end has a connection device for connection to an input part of the steady rest, wherein the inner end of the actuating part has a supporting device by means of which the actuating part is supported on the carrier in the length direction, and the supporting device comprises a roller bearing arrangement which provides a roller-bearing mounting between a supporting part of the supporting device and the carrier, with a dual-action pneumatic cylinder attached to the carrier, the piston of which is movably coupled to the actuating part via a coupling device, wherein the coupling device has a slide which is connected to the piston and is mounted on the carrier so as to be movable in a length direction at right angles to the height direction, and which has at least one sliding block guide running obliquely relative to the length direction and the height direction, and defining a sliding block track along which the at least one sliding block element of the coupling device is movable in a guided manner, wherein the sliding block track encloses an angle of inclination (α) with the length direction which is smaller than 45°, and wherein the actuating part is connected to the sliding block element at an inner end opposite the outer end.
An electroacoustic transducer comprising: a first electrode; a second electrode; a piezoelectric material at least partially sandwiched between the first electrode and the second electrode; and a flexible electrical connector in electrical connection with the first or second electrode at discrete points around a periphery of that electrode, the discrete points being distributed about a substantial portion of that periphery. a first electrode; a second electrode; a piezoelectric material at least partially sandwiched between the first electrode and the second electrode; and a flexible electrical connector in electrical connection with the first or second electrode at discrete points around a periphery of that electrode, the discrete points being distributed about a substantial portion of that periphery.
A pharmaceutical composition for oral formulation, comprising a drug and an adjuvant, wherein the drug is polypeptide, insulin, or growth hormone; the adjuvant is composed of: a surfactant, an acrylic polymer, chitin or its derivatives, and a metal ion chelating agent; the surfactant is sodium lauryl sulfate, the acrylic polymer is carbomer, the chitin or its derivatives are chitosan, and the metal ion chelating agent is sodium citrate.
An x-ray imaging system for imaging a human patient comprising: an x-ray source for producing x-ray radiation, said x-ray source comprising a target having a plurality of focal points (1303a, 1303b, 1304a, 1304b), and said x-ray source being configured to generate a plurality of electron beams (1301a, 1301b, 1302a, 1302b) to impinge on said plurality of focal points, wherein said x-ray radiation is created as x-ray beams when said electron beams impinge on said focal points; an x-ray detector for measuring an amount of said x-ray radiation passing through said human patient and striking said detector; a controller for selecting a region of interest in said human patient; and said x-ray source configured for electronic region of interest filtering, said electronic region of interest filtering comprising controlling electron beams such that: electron beams (1302a, 1302b) fully illuminate only focal points (1304a, 1304b) that when impinged create x-ray beams (1309a, 1309b) that expose said region of interest in said patient; and reduced electron beams (1301a, 1301b) illuminate focal points (1303a, 1303b) that when impinged create x-ray radiation (1310a, 1310b) that exposes an area outside said region of interest in said patient, or electron beams are redirected away from focal points (1303a, 1303b). an x-ray source for producing x-ray radiation, said x-ray source comprising a target having a plurality of focal points (1303a, 1303b, 1304a, 1304b), and said x-ray source being configured to generate a plurality of electron beams (1301a, 1301b, 1302a, 1302b) to impinge on said plurality of focal points, wherein said x-ray radiation is created as x-ray beams when said electron beams impinge on said focal points; an x-ray detector for measuring an amount of said x-ray radiation passing through said human patient and striking said detector; a controller for selecting a region of interest in said human patient; and said x-ray source configured for electronic region of interest filtering, said electronic region of interest filtering comprising controlling electron beams such that: electron beams (1302a, 1302b) fully illuminate only focal points (1304a, 1304b) that when impinged create x-ray beams (1309a, 1309b) that expose said region of interest in said patient; and reduced electron beams (1301a, 1301b) illuminate focal points (1303a, 1303b) that when impinged create x-ray radiation (1310a, 1310b) that exposes an area outside said region of interest in said patient, or electron beams are redirected away from focal points (1303a, 1303b). electron beams (1302a, 1302b) fully illuminate only focal points (1304a, 1304b) that when impinged create x-ray beams (1309a, 1309b) that expose said region of interest in said patient; and reduced electron beams (1301a, 1301b) illuminate focal points (1303a, 1303b) that when impinged create x-ray radiation (1310a, 1310b) that exposes an area outside said region of interest in said patient, or electron beams are redirected away from focal points (1303a, 1303b).
Leg alignment apparatus for use in total arthroplasty of left and right knees, the apparatus comprising first and second parts (10, 100), the first part comprising an intramedullary rod, a femoral body for location on or adjacent to an anterior surface of a femur, a support element which extends or is extendable from the femoral body to the intramedullary rod for holding the femoral body stationary or substantially stationary relative to the intramedullary rod, a condylar locator which is pivotable relative to the femoral body and which is seatable on a distal end of the femur, and a varus/valgus indicator, and the second part comprising a soft-tissue tensioning element to apply a separation between the femur and the tibia, characterised in that the first part includes a soft-tissue tensioning connector which is pivotably mounted on the femoral body, the soft-tissue tensioning element and the femoral body being pivotably and releasably interconnected or interconnectable via the soft-tissue tensioning connector, and in that the varus/valgus indicator indicates an angular alignment of the knee based on the intramedullary rod and the soft tissue tensioning connector,.
A power converter comprising: an insulative support; a rectifier module coupled to and supported by the insulative support, the rectifier module configured to receive AC power from a source; plate-like DC bus elements (68, 72) disposed in the insulative support and separated from one another by an insulative plate, the DC bus elements (68, 72) receiving DC power from the rectifier module; a power converter circuit supported by the insulative support and contacting the DC bus elements (68, 72) to receive the DC power and to convert the DC power to a desired output power; and a drive circuit board supported by the insulative support and coupled to the power converter circuit to command operation of the power converter circuit during operation. an insulative support; a rectifier module coupled to and supported by the insulative support, the rectifier module configured to receive AC power from a source; plate-like DC bus elements (68, 72) disposed in the insulative support and separated from one another by an insulative plate, the DC bus elements (68, 72) receiving DC power from the rectifier module; a power converter circuit supported by the insulative support and contacting the DC bus elements (68, 72) to receive the DC power and to convert the DC power to a desired output power; and a drive circuit board supported by the insulative support and coupled to the power converter circuit to command operation of the power converter circuit during operation.
A method to feed two wrapping sheets in a packing machine, in particular for smoking articles; the feeding method comprises the steps of: feeding an initial wrapping sheet with a double width; dividing the initial wrapping sheet with a double width into two so as to obtain two final wrapping sheets with a single width; making a pre-weakened separation line in the initial wrapping sheet; and dividing the initial wrapping sheet into two by applying only and solely a force, which causes a tear along the pre-weakened separation line; wherein the separation line comprises a plurality of through incisions, which are obtained through the initial wrapping sheet, are aligned with one another, and are separate from one another; and wherein the division of the initial wrapping sheet into two involves tearing the wrapping material present between two adjacent through incisions; the feeding method is characterized in that each through incision has a central portion with a straight shape and at least one end portion with a curved shape. feeding an initial wrapping sheet with a double width; dividing the initial wrapping sheet with a double width into two so as to obtain two final wrapping sheets with a single width; making a pre-weakened separation line in the initial wrapping sheet; and dividing the initial wrapping sheet into two by applying only and solely a force, which causes a tear along the pre-weakened separation line; wherein the separation line comprises a plurality of through incisions, which are obtained through the initial wrapping sheet, are aligned with one another, and are separate from one another; and wherein the division of the initial wrapping sheet into two involves tearing the wrapping material present between two adjacent through incisions; the feeding method is characterized in that each through incision has a central portion with a straight shape and at least one end portion with a curved shape.
A monoclonal neutralizing antibody, recombinant or synthetic antigen-binding fragments thereof able to recognise and bind an epitope comprised in the aa. 732 to aa. 874 region of SEQ ID No. 2 of ADAMTS-5 with a dissociation constant (Kd) < 100 nM, the dissociation constant being determined as specified in the section "Evaluation of anti-Sp_ADAMTS-5scFv and/ or mAb affinity and kinetic constants by Surface Plasmon Resonance measurements" found under the header 'Materials and Methods' in the description.
Air guide designed to be integrated at the front of a vehicle between a front face of said vehicle and a heat exchanger of said vehicle, said air guide has an attachment frame defining a median plane and a plurality of walls (2, 3, 4, 5) secured to said attachment frame so as to form a duct oriented along a component normal to said median plane, said walls being flat-moulded in one piece with said attachment frame in said median plane, so as to be able to raise said walls relative to said median plane to form said duct, characterized in that at least one of said walls has a main part (20, 30) extended by at least one end (21, 22; 31, 32) that is mobile relative to said main part so as to be folded back towards another wall that is adjacent thereto once raised.
An inflatable structure transformable between a deflated state and an inflated state, the inflatable structure comprising a drop stitch fabric having a first layer and a second layer tethered by drop stitches, the inflatable structure being provided with folding lines defining the inflatable structure into two or more interconnected chambers, the folding lines comprising coupling means coupling the first layer to the second layer, wherein dimensions of the folding lines and/or coupling means are adapted to enable the inflatable structure to be foldable along the folding lines in both the deflated state and the inflated state, characterized in that the folding lines comprise at least a first set of folding lines defining the inflatable structure into a first and at least a second interconnected chamber, the at least first set of folding lines comprising a first folding line and at least a second adjacent folding line at least partly parallel to the first folding line, the at least first set of folding lines having an extent extending at least 50 percent, more preferred at least 60 percent and most preferred at least 70 percent along a corresponding folding line elongation rendered by the at least first set of folding lines i.e. fictive extension from edge to edge of the inflatable structure and/or drop stitch fabric, a width of the at least first set of folding lines defined by the number of folding lines defining an angle (α) at which edges (404, 405) of the first interconnected chamber and the at least second interconnected chamber upon folding in the inflated state abut.
Dapansutrile or a pharmaceutically acceptable solvate thereof as a pharmaceutical compound for use in a method for preventing and/or treating Alzheimer's disease in a subject.
Method for carrying out open-loop or closed-loop control of a vehicle brake system in which, when a braking request signal (S5, S) is present, brake pressures are set at brakes (8, 10) on axles (VA, HA) and/or wheels (3, 4) of the vehicle by means of a method for distributing brake pressure, wherein when the braking request signal (S5, S6) is present before the initiation of the braking it is decided whether, or to what extent, the brake pressure is distributed in a brake wear-pressure distribution system or in a grip-pressure distribution system for the subsequent initiation of the braking, characterized in that the decision relating to the brake pressure distribution is made on the basis of current received or detected data relating to frictional conditions (μ) or adhesion conditions between a roadway surface and tire surfaces (3a, 4a) of the vehicle.
A method of isolating nucleic acid and protein from the same biological sample, comprising, in the following order: a) disrupting the biological sample; b) contacting the disrupted biological sample of (a) with a protein lysis buffer that lacks any component that denatures or reduces protein to produce a first lysate; c) centrifuging the first lysate of (b) to produce a first supernatant containing protein and a pellet containing nucleic acid; d) removing the first supernatant of (c), thereby isolating protein from the biological sample; e) contacting the pellet of (d) with nucleic acid lysis buffer to produce a second lysate; f) centrifuging the second lysate of (e) to produce a second supernatant containing nucleic acid; and g) removing the second supernatant of (f), thereby isolating nucleic acid from the same biological sample. a) disrupting the biological sample; b) contacting the disrupted biological sample of (a) with a protein lysis buffer that lacks any component that denatures or reduces protein to produce a first lysate; c) centrifuging the first lysate of (b) to produce a first supernatant containing protein and a pellet containing nucleic acid; d) removing the first supernatant of (c), thereby isolating protein from the biological sample; e) contacting the pellet of (d) with nucleic acid lysis buffer to produce a second lysate; f) centrifuging the second lysate of (e) to produce a second supernatant containing nucleic acid; and g) removing the second supernatant of (f), thereby isolating nucleic acid from the same biological sample.
A compound represented by the following formula, or a salt thereof: wherein X represents -CH=CH-, -NH-, a sulfur atom or an oxygen atom; and n represents an integer of 0 to 2.
Use of a thermoplastic composition in nanostructured form, mainly composed of a graft copolymer having polyamide blocks formed from a polyolefin backbone, chosen from ethylene/maleic anhydride and ethylene/alkyl (meth)acrylate/maleic anhydride copolymers, and from at least one polyamide graft, for the thermal protection, at a temperature above 150°C, of a substrate, characterized in that it relates to tubes or pipes for fluid transfer lines comprising an inner layer of PA-11 and/or PA-12 type polyamide and an outer layer formed from the thermoplastic composition.
A mailer for delivery of a digital media disk, the mailer comprising: a back sheet (10, 71) having a back sheet opening (13, 65, 73) and a reclosable closing flap (11, 66, 74); a middle sheet (20, 75) having a middle sheet opening (23, 64, 76), the middle sheet being fastened on top of the back sheet such that the middle sheet opening (23, 64, 76) aligns with the back sheet opening (13, 65, 73), and whereby a disk receiving slot is formed between the back sheet (10, 71) and the middle sheet (20, 75), the disk receiving slot dimensioned to enclose the digital media disk, the aligned openings located in a center of the disk receiving slot, a top face of the middle sheet including return mail markings; and a top sheet (40, 60, 78) removably attached on top of the middle sheet (20, 75), a top face of the top sheet including mailing markings, the closing flap (11, 66, 74) of the back sheet (10, 71) folding into a closed position over the top sheet (40, 60, 78) and the middle sheet (20, 75). a back sheet (10, 71) having a back sheet opening (13, 65, 73) and a reclosable closing flap (11, 66, 74); a middle sheet (20, 75) having a middle sheet opening (23, 64, 76), the middle sheet being fastened on top of the back sheet such that the middle sheet opening (23, 64, 76) aligns with the back sheet opening (13, 65, 73), and whereby a disk receiving slot is formed between the back sheet (10, 71) and the middle sheet (20, 75), the disk receiving slot dimensioned to enclose the digital media disk, the aligned openings located in a center of the disk receiving slot, a top face of the middle sheet including return mail markings; and a top sheet (40, 60, 78) removably attached on top of the middle sheet (20, 75), a top face of the top sheet including mailing markings, the closing flap (11, 66, 74) of the back sheet (10, 71) folding into a closed position over the top sheet (40, 60, 78) and the middle sheet (20, 75).