A compound of Formula: wherein: Z 1 is pyrazole optionally substituted with one or more of the following: halo, -OH, -CN, - COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, or -C3-C7 cycloalkyl; Z 2 is phenyl, pyridine, or pyrazole, wherein the phenyl, pyridine, or pyrazole is optionally substituted with, H, halo, -OH, -CN, -COOR', -OR', -OR'OR", -O(CH 2) 2 NR'R", -SR', - OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or a 3-to 10-membered heterocycle, and wherein the -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is optionally substituted with one or more of the following: halo, -OH, - CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, or -C3-C7 cycloalkyl, and wherein the R' or R" are independently -H, methyl or ethyl; R 1 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl, wherein the -C1-C6 alkyl or -C3-C7 cycloalkyl is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", or -S 2 R'; R is methyl; X is a bond or -OCH(R 4)-, wherein R 4 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl; R 2 and R 3 are independently H, -C1-C6 alkyl, -C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle, wherein the -C1-C6 alkyl, -C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -CNR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 11-membered heterocycle, wherein the -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 11-membered heterocycle is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -CH 2 NR'R", -OR', -OR'R", -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, and wherein R 5 is -C1-C6 alkyl, -OCH 2 CH 2 -, -NR 6 CH 2 CH 2 -, -NC CH 2 CH 2 -; R 6 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl; and R' or R" is independently -H or -C1-C6 alkyl, or R' and R" together, optionally attaching to N or O atom, form a 4- to 8-membered cyclic structure. Z 1 is pyrazole optionally substituted with one or more of the following: halo, -OH, -CN, - COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, or -C3-C7 cycloalkyl; Z 2 is phenyl, pyridine, or pyrazole, wherein the phenyl, pyridine, or pyrazole is optionally substituted with, H, halo, -OH, -CN, -COOR', -OR', -OR'OR", -O(CH 2) 2 NR'R", -SR', - OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or a 3-to 10-membered heterocycle, and wherein the -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is optionally substituted with one or more of the following: halo, -OH, - CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, or -C3-C7 cycloalkyl, and wherein the R' or R" are independently -H, methyl or ethyl; R 1 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl, wherein the -C1-C6 alkyl or -C3-C7 cycloalkyl is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", or -S 2 R'; R is methyl; X is a bond or -OCH(R 4)-, wherein R 4 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl; R 2 and R 3 are independently H, -C1-C6 alkyl, -C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle, wherein the -C1-C6 alkyl, -C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -CNR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 11-membered heterocycle, wherein the -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, or 3- to 11-membered heterocycle is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -CH 2 NR'R", -OR', -OR'R", -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C1-C6 alkyl, aryl, -C3-C7 cycloalkyl, and wherein R 5 is -C1-C6 alkyl, -OCH 2 CH 2 -, -NR 6 CH 2 CH 2 -, -NC CH 2 CH 2 -; R 6 is H, -C1-C6 alkyl or -C3-C7 cycloalkyl; and R' or R" is independently -H or -C1-C6 alkyl, or R' and R" together, optionally attaching to N or O atom, form a 4- to 8-membered cyclic structure.