A method of normalizing a first diagnostic result of a subordinate clinical diagnostic analyzer to a second diagnostic result of a master clinical diagnostic analyzer comprising the steps of obtaining a normalized excitation intensity spectrum of the master clinical diagnostic analyzer, obtaining a normalized excitation intensity spectrum of the subordinate clinical diagnostic analyzer, obtaining a normalized responsivity intensity spectrum of the master clinical diagnostic analyzer, obtaining a normalized responsivity intensity spectrum of the subordinate clinical diagnostic analyzer, obtaining a normalized excitation/emission spectrum of a solid inorganic photostable fluorophore calibration target, reading the solid inorganic photostable fluorophore calibration target in the master clinical diagnostic analyzer thereby obtaining a first response value, reading the solid inorganic photostable fluorophore calibration target in the subordinate clinical diagnostic analyzer thereby obtaining a second response value, determining the gain ratio (G R) of the master clinical diagnostic analyzer to the subordinate clinical diagnostic analyzer based upon the first and second response values, based on equation G R = G A ⋅ φ A G B ⋅ φ B = E A E B ⋅ ∑ χ S RB χ ⋅ ∑ ξ S B ξ ⋅ ECglass ξ χ ∑ χ S RA χ ⋅ ∑ ξ S A ξ ⋅ ECglass ξ χ, using the determined gain ratio (G R), determining a multiplicative normalization factor between a normalized subordinate clinical diagnostic analyzer and the master clinical diagnostic analyzer, determining the relative adsorption/emission spectrum of a first fluorescently labeled dye whereas the first fluorescently labeled dye is a diagnostic assay component, obtaining a first diagnostic result from a specific patient specimen or sample incorporating the first fluorescently labeled dye using the normalized subordinate clinical diagnostic analyzer, and modifying the first diagnostic result by the multiplicative normalization factor to obtain a second diagnostic result wherein the second diagnostic result is a normalized approximation to a diagnostic result which would be obtained by analyzing the specific patient specimen or sample on the master clinical diagnostic analyzer. obtaining a normalized excitation intensity spectrum of the master clinical diagnostic analyzer, obtaining a normalized excitation intensity spectrum of the subordinate clinical diagnostic analyzer, obtaining a normalized responsivity intensity spectrum of the master clinical diagnostic analyzer, obtaining a normalized responsivity intensity spectrum of the subordinate clinical diagnostic analyzer, obtaining a normalized excitation/emission spectrum of a solid inorganic photostable fluorophore calibration target, reading the solid inorganic photostable fluorophore calibration target in the master clinical diagnostic analyzer thereby obtaining a first response value, reading the solid inorganic photostable fluorophore calibration target in the subordinate clinical diagnostic analyzer thereby obtaining a second response value, determining the gain ratio (G R) of the master clinical diagnostic analyzer to the subordinate clinical diagnostic analyzer based upon the first and second response values, based on equation G R = G A ⋅ φ A G B ⋅ φ B = E A E B ⋅ ∑ χ S RB χ ⋅ ∑ ξ S B ξ ⋅ ECglass ξ χ ∑ χ S RA χ ⋅ ∑ ξ S A ξ ⋅ ECglass ξ χ, using the determined gain ratio (G R), determining a multiplicative normalization factor between a normalized subordinate clinical diagnostic analyzer and the master clinical diagnostic analyzer, determining the relative adsorption/emission spectrum of a first fluorescently labeled dye whereas the first fluorescently labeled dye is a diagnostic assay component, obtaining a first diagnostic result from a specific patient specimen or sample incorporating the first fluorescently labeled dye using the normalized subordinate clinical diagnostic analyzer, and modifying the first diagnostic result by the multiplicative normalization factor to obtain a second diagnostic result wherein the second diagnostic result is a normalized approximation to a diagnostic result which would be obtained by analyzing the specific patient specimen or sample on the master clinical diagnostic analyzer.