A process for the manufacture of an immediate release oral pharmaceutical composition comprising dexketoprofen trometamol in the form of tablets or granules, wherein the pharmaceutical composition comprises between 3 % and 60 % by weight of dexketoprofen trometamol in respect of the total amount of the pharmaceutical composition, wherein the total amount of lubricant or lubricants present in the pharmaceutical composition ranges from 0.5 to 6 % by weight in respect of the total amount of the pharmaceutical composition; wherein the total amount of disintegrant or disintegrants present in the pharmaceutical composition ranges from 2 to 20 % by weight in respect of the total amount of the pharmaceutical composition; wherein the total amount of diluent or diluents present in the pharmaceutical composition ranges from 15 % to 85 % by weight in respect of the total amount of the pharmaceutical composition, wherein the process for the manufacture of the pharmaceutical composition comprises the steps of: i) sieving when appropriate the intra-granular ingredients to form uniformly sized particles of intra-granular ingredients; ii) either mixing the particles of intra-granular ingredients and dexketoprofen trometamol, preferably in a granulator-mixer; granulate the obtained mixture with at least one binder, preferably the binder comprises water, more preferably consists essentially of water; even more preferably consists of water; wherein the final water content of the granulate is from about 5 % to about 30 % by weight; iii) or mixing the particles of intra-granular ingredients, preferably in a granulator-mixer; granulate the obtained mixture with a solution or dispersion of dexketoprofen trometamol in water; wherein the final water content of the granulate is from about 5 % to about 30 % by weight; iv) optionally and/or if required, performing a sieving of the granulate obtained in either step (ii) or step (iii); v) drying the granulate of the previous step (ii), (iii) or (iv) to an endpoint water content of less than about 8 % by weight, preferably less than 6.5 by weight, more preferably from about 1.0 % to 5.5 % by weight, wherein the drying is preferably carried out in a fluid bed at an input temperature between 35 and 105 °C; vi) mixing the granulate of the previous step with the extra-granular agents and blending to form a blend; vii) and, when the pharmaceutical composition is in the form of tablets, compressing the blend into tablets using a tablet press. i) sieving when appropriate the intra-granular ingredients to form uniformly sized particles of intra-granular ingredients; ii) either mixing the particles of intra-granular ingredients and dexketoprofen trometamol, preferably in a granulator-mixer; granulate the obtained mixture with at least one binder, preferably the binder comprises water, more preferably consists essentially of water; even more preferably consists of water; wherein the final water content of the granulate is from about 5 % to about 30 % by weight; iii) or mixing the particles of intra-granular ingredients, preferably in a granulator-mixer; granulate the obtained mixture with a solution or dispersion of dexketoprofen trometamol in water; wherein the final water content of the granulate is from about 5 % to about 30 % by weight; iv) optionally and/or if required, performing a sieving of the granulate obtained in either step (ii) or step (iii); v) drying the granulate of the previous step (ii), (iii) or (iv) to an endpoint water content of less than about 8 % by weight, preferably less than 6.5 by weight, more preferably from about 1.0 % to 5.5 % by weight, wherein the drying is preferably carried out in a fluid bed at an input temperature between 35 and 105 °C; vi) mixing the granulate of the previous step with the extra-granular agents and blending to form a blend; vii) and, when the pharmaceutical composition is in the form of tablets, compressing the blend into tablets using a tablet press.