A loading system comprising: an adjunct loading member comprising a supporting member; at least one adjunct material configured to be transferred from the adjunct loading member to a jaw of first and second jaws (32, 34) of an end effector, the first and second jaws being configured to clamp tissue therebetween, wherein the supporting member is configured to releasably retain the adjunct material, and at least a portion of the adjunct loading member is configured to crack, break, deform or otherwise change configuration upon the application of load thereto, to thereby release the adjunct material; and an adhesive depot having an adhesive configured to transition from a non-flowable state to a flowable state upon the application of heat, when the adjunct material is released from the adjunct loading member and transferred to the jaw, to retain the adjunct material on the jaw, wherein the adhesive depot comprises a plurality of reservoirs (424, 426) formed in the supporting member and each releasably holding the adhesive in the non-flowable state in which the adhesive is substantially non-liquid such that the adhesive can transition under the application of at least one of heat and force to the flowable state in which the adhesive is at least partially liquid; and the adjunct material having structures therein configured to receive the adhesive transitioning to the flowable state when the adhesive material is released from a respective one of the plurality of reservoirs and through the structures to a jaw-facing surface of the adjunct material to thereby retain the adjunct material on the jaw. an adjunct loading member comprising a supporting member; at least one adjunct material configured to be transferred from the adjunct loading member to a jaw of first and second jaws (32, 34) of an end effector, the first and second jaws being configured to clamp tissue therebetween, wherein the supporting member is configured to releasably retain the adjunct material, and at least a portion of the adjunct loading member is configured to crack, break, deform or otherwise change configuration upon the application of load thereto, to thereby release the adjunct material; and an adhesive depot having an adhesive configured to transition from a non-flowable state to a flowable state upon the application of heat, when the adjunct material is released from the adjunct loading member and transferred to the jaw, to retain the adjunct material on the jaw, wherein the adhesive depot comprises a plurality of reservoirs (424, 426) formed in the supporting member and each releasably holding the adhesive in the non-flowable state in which the adhesive is substantially non-liquid such that the adhesive can transition under the application of at least one of heat and force to the flowable state in which the adhesive is at least partially liquid; and the adjunct material having structures therein configured to receive the adhesive transitioning to the flowable state when the adhesive material is released from a respective one of the plurality of reservoirs and through the structures to a jaw-facing surface of the adjunct material to thereby retain the adjunct material on the jaw.