mhurhangee/ep-ind-claims huggingface dataset:
A method for detecting MR signals of an object under examination in a bore of an MR imaging system, in which the MR signals of the object under examination are detected with a plurality of receiving channels at the same time using a parallel imaging technique, wherein the MR signals are spin-echoes generated with a spin-echo based imaging sequence, the method comprising: - applying a first magnetic field gradient in a slice selection direction while applying an RF excitation pulse of the spin echo based imaging sequence, wherein the first magnetic field gradient has a first polarity during the application of the RF excitation pulse, - applying a second magnetic field gradient in the slice selection direction while applying at least a first RF refocusing pulse of the spin echo based imaging sequence, wherein the second magnetic field gradient has a second polarity opposite to the first polarity, wherein a simultaneous multislice imaging technology is used such that multiple slices of the object under examination are simultaneously excited with the RF excitation pulse and the signals refocused with the at least one RF refocusing pulse - detecting the MR signals of the at least one spin echo in order to generate an MR image based on the detected MR signals, wherein the detected MR signals are used to generate a weighting matrix used in the parallel imaging technique to reconstruct missing k-space data not acquired during the spin echo based imaging sequence from acquired k-space data acquired with the detected MR signals, in order to reduce 3rd arm artifacts, which are areas with high signal intensity in peripheral regions of the bore due to magnetic field inhomogeneities. - applying a first magnetic field gradient in a slice selection direction while applying an RF excitation pulse of the spin echo based imaging sequence, wherein the first magnetic field gradient has a first polarity during the application of the RF excitation pulse, - applying a second magnetic field gradient in the slice selection direction while applying at least a first RF refocusing pulse of the spin echo based imaging sequence, wherein the second magnetic field gradient has a second polarity opposite to the first polarity, wherein a simultaneous multislice imaging technology is used such that multiple slices of the object under examination are simultaneously excited with the RF excitation pulse and the signals refocused with the at least one RF refocusing pulse - detecting the MR signals of the at least one spin echo in order to generate an MR image based on the detected MR signals, wherein the detected MR signals are used to generate a weighting matrix used in the parallel imaging technique to reconstruct missing k-space data not acquired during the spin echo based imaging sequence from acquired k-space data acquired with the detected MR signals, in order to reduce 3rd arm artifacts, which are areas with high signal intensity in peripheral regions of the bore due to magnetic field inhomogeneities.
Container, in particular a beverage container, comprising an inner container wall and an outer container wall and an intermediate space lying between the container walls (2, 4), wherein the intermediate space is filled with a mixture which contains phase-change material and graphite powder, characterized in that the graphite powder is introduced into the phase-change material in such a way that the mixture has a sludgy consistency at a temperature at which the phase-change material is liquid, such that leakage of the phase-change material is prevented and that the liquid phase change material does not collect due to the force of gravity in the bottom region of the container.
A method for verifying software during loading within a device, comprising: obtaining software stored in a non-secure storage within the device or external to the device; attempting to verify the software when it is loaded for execution by using a pre-generated verification tag to confirm that the software being loaded is the same as the one used to generate the pre-generated verification tag while avoiding an authentication of the software; if verification fails or no pre-generated verification tag is available, then authenticating the software when it is loaded for execution by the device, generating a new verification tag for the software if authentication of the software is successful, the new verification tag based on the software, device-specific secret data, and device data including one or more states from one or more one-time blowable fuses, wherein at least one of the one or more one-time blowable fuses is blown to change the device data every time a new version of the software is obtained, and storing the new verification tag; and wherein verifying the software is less time consuming and/or less resource intensive than authenticating the software. obtaining software stored in a non-secure storage within the device or external to the device; attempting to verify the software when it is loaded for execution by using a pre-generated verification tag to confirm that the software being loaded is the same as the one used to generate the pre-generated verification tag while avoiding an authentication of the software; if verification fails or no pre-generated verification tag is available, then authenticating the software when it is loaded for execution by the device, generating a new verification tag for the software if authentication of the software is successful, the new verification tag based on the software, device-specific secret data, and device data including one or more states from one or more one-time blowable fuses, wherein at least one of the one or more one-time blowable fuses is blown to change the device data every time a new version of the software is obtained, and storing the new verification tag; and authenticating the software when it is loaded for execution by the device, generating a new verification tag for the software if authentication of the software is successful, the new verification tag based on the software, device-specific secret data, and device data including one or more states from one or more one-time blowable fuses, wherein at least one of the one or more one-time blowable fuses is blown to change the device data every time a new version of the software is obtained, and storing the new verification tag; and wherein verifying the software is less time consuming and/or less resource intensive than authenticating the software.
A shelf stable transdermal delivery patch for administering vitamin B 12 to a subject, comprising (a) a backing layer; (b) a skin contact adhesive layer adjacent to the backing layer, said skin contact adhesive layer including (i) a polymeric adhesive; (ii) vitamin B 12; (iii) a penetration enhancer effective to enhance transdermal uptake of vitamin B 12 by said subject; and (iv) a vitamin B 12 stabilizer to stabilize the vitamin B 12 contained within the adhesive layer, and (c) a removable impermeable layer overlaying the skin contact adhesive layer, said removable impermeable layer preventing vitamin B 12 release from the skin contact adhesive layer prior to use, wherein said penetration enhancer is a combination of: (a) menthone at 1.3 wt % to 12.0 wt %, and (b) propylene glycol at 0.8 wt % to 12.0 wt %, based on the skin contact adhesive layer's dry weight. (a) a backing layer; (b) a skin contact adhesive layer adjacent to the backing layer, said skin contact adhesive layer including (i) a polymeric adhesive; (ii) vitamin B 12; (iii) a penetration enhancer effective to enhance transdermal uptake of vitamin B 12 by said subject; and (iv) a vitamin B 12 stabilizer to stabilize the vitamin B 12 contained within the adhesive layer, and (i) a polymeric adhesive; (ii) vitamin B 12; (iii) a penetration enhancer effective to enhance transdermal uptake of vitamin B 12 by said subject; and (iv) a vitamin B 12 stabilizer to stabilize the vitamin B 12 contained within the adhesive layer, and (c) a removable impermeable layer overlaying the skin contact adhesive layer, said removable impermeable layer preventing vitamin B 12 release from the skin contact adhesive layer prior to use, wherein said penetration enhancer is a combination of: (a) menthone at 1.3 wt % to 12.0 wt %, and (b) propylene glycol at 0.8 wt % to 12.0 wt %, based on the skin contact adhesive layer's dry weight.
A pharmaceutical composition, comprising: (i) azvudine or a pharmaceutically acceptable salt, a stereoisomer or an isotopic derivative thereof; (ii) an EGFR/TKI inhibitor, wherein the EGFR/TKI inhibitor is selected from the group consisting of osimertinib, doxitinib and a combination thereof, wherein doxitinib is a compound according to the following structure: (i) azvudine or a pharmaceutically acceptable salt, a stereoisomer or an isotopic derivative thereof; (ii) an EGFR/TKI inhibitor, wherein the EGFR/TKI inhibitor is selected from the group consisting of osimertinib, doxitinib and a combination thereof, wherein doxitinib is a compound according to the following structure:
Optical sensor for motor vehicles having an optical sensor for detecting the wetting of a windscreen of the motor vehicle and/or for detecting the ambient light of the motor vehicle, wherein the optical sensor is attached to a main circuit board that can be mounted lying on the inner face of the windscreen, and having a moisture sensor for detecting the moisture and/or temperature on the inner face of the windscreen, wherein the moisture sensor is attached to one end of a circuit board and in the mounted state is pressed against the inner face of the windscreen, wherein the moisture sensor is electrically coupled to the optical sensor and is enclosed in part in a common housing having the optical sensor, characterized in that the end of the circuit board that is supporting the moisture sensor is a rigid-flexible circuit board that is formed as one piece with the main circuit board of the optical sensor and has a flexible section, and in that the rigid-flexible end can be produced from the main circuit board in that, for example, layers of the main circuit board are, at this end, accordingly milled away or etched away through the use of chemicals or removed through the use of an optical method, so that the remaining material has a particular flexibility along mainly an axis that is perpendicular with respect to the main circuit board.
High-temperature insulating system for thermally insulating a process space of a high-temperature furnace, which has at least two insulating layers (4, 5) which follow one another in a shielding direction, comprising - a first insulating layer based on refractory metal, - a second insulating layer composed of a carbon-based material which is arranged in the direction facing away from the process space relative to the first insulating layer, where the first insulating layer continues into a surround which surrounds the second insulating layer at least in sections in the shielding direction, characterized in that the insulating layer (4, 7) directly adjoining the second insulating layer in a direction opposite to the shielding direction is kept at a distance from the second insulating layer by spacers. - a first insulating layer based on refractory metal, - a second insulating layer composed of a carbon-based material which is arranged in the direction facing away from the process space relative to the first insulating layer,
An autonomous driving safety control system based on edge infrastructure, the autonomous driving safety control system comprising: an autonomous driving system controlling autonomous driving; an error detection unit detecting a fallback situation; and a safety controller driving a safety process for each fallback situation by interworking with an edge infrastructure when a fallback situation occurs, wherein, when the error detection unit detects a fallback situation in which it is impossible to switch a driving control right to a driver, and either autonomous driving of the autonomous driving system is impossible, or a fallback minimal risk maneuver, MRM, set in the autonomous driving system itself is impossible and location information of a safety zone where an emergency stop is possible is not received, the safety controller makes an emergency stop by controlling the autonomous driving system in conjunction with the edge infrastructure, transmits the fallback situation and location information generated by detecting a location of a passenger who escapes to the outside of the vehicle, and shares the location information of the passenger through the edge infrastructure. an autonomous driving system controlling autonomous driving; an error detection unit detecting a fallback situation; and a safety controller driving a safety process for each fallback situation by interworking with an edge infrastructure when a fallback situation occurs, wherein, when the error detection unit detects a fallback situation in which it is impossible to switch a driving control right to a driver, and either autonomous driving of the autonomous driving system is impossible, or a fallback minimal risk maneuver, MRM, set in the autonomous driving system itself is impossible and location information of a safety zone where an emergency stop is possible is not received, the safety controller makes an emergency stop by controlling the autonomous driving system in conjunction with the edge infrastructure, transmits the fallback situation and location information generated by detecting a location of a passenger who escapes to the outside of the vehicle, and shares the location information of the passenger through the edge infrastructure.
A pneumatic tire having a tread comprising a block in which a sipe is formed, wherein at least one wall surface of the sipe is formed in a waveform including a plurality of curved portions when viewed from a tire radial direction, the curved portions include an inwardly curved portion that bulges toward the inside of the sipe and an outwardly curved portion that bulges toward the outside of the sipe, and the radii of curvature of the inwardly curved portion and the outwardly curved portion differ from each other, characterized in that a straight portion is formed between the inwardly curved portion and the outwardly curved portion. at least one wall surface of the sipe is formed in a waveform including a plurality of curved portions when viewed from a tire radial direction, the curved portions include an inwardly curved portion that bulges toward the inside of the sipe and an outwardly curved portion that bulges toward the outside of the sipe, and the radii of curvature of the inwardly curved portion and the outwardly curved portion differ from each other, characterized in that a straight portion is formed between the inwardly curved portion and the outwardly curved portion.
A heavy-duty vehicle comprising a frame; a cabin; a forward compartment extending from the cabin towards a front end of the vehicle; and a crash impact absorbing arrangement at least partly arranged in the forward compartment, wherein the crash impact absorbing arrangement comprises: a front structure having a lower portion attached to the frame and an upper portion arranged between the cabin and the front end of the vehicle, the front structure being configured to collapse towards a rear end of the vehicle when a force directed towards the rear end of the vehicle acting on the upper portion of the front structure reaches a threshold force; a rear structure having a lower portion attached to the frame and an upper portion, the rear structure being configured to withstand a force directed towards the rear end of the vehicle acting on the upper portion of the rear structure exceeding the threshold force; and at least one deformable energy absorbing structure (25a-b) arranged between the upper portion of the front structure and the upper portion of the rear structure, and configured to transfer a force directed towards the rear end of the vehicle acting on the upper portion of the front structure to the upper portion of the rear structure, while being deformed to allow movement of the upper portion of the front structure towards the upper portion of the rear structure, characterized in that the upper portion of the rear structure is arranged between the cabin and the upper portion of the front structure. a front structure having a lower portion attached to the frame and an upper portion arranged between the cabin and the front end of the vehicle, the front structure being configured to collapse towards a rear end of the vehicle when a force directed towards the rear end of the vehicle acting on the upper portion of the front structure reaches a threshold force; a rear structure having a lower portion attached to the frame and an upper portion, the rear structure being configured to withstand a force directed towards the rear end of the vehicle acting on the upper portion of the rear structure exceeding the threshold force; and at least one deformable energy absorbing structure (25a-b) arranged between the upper portion of the front structure and the upper portion of the rear structure, and configured to transfer a force directed towards the rear end of the vehicle acting on the upper portion of the front structure to the upper portion of the rear structure, while being deformed to allow movement of the upper portion of the front structure towards the upper portion of the rear structure, characterized in that the upper portion of the rear structure is arranged between the cabin and the upper portion of the front structure.
A lubricant composition for use in combustion engines comprising A) an additive mixture that consists of a) At least one compound having the chemical structure: wherein R represents C 3 -C 18 alkyl and R a and R b represent C 6 -C 20 alkyl; b) an O,O,O-tris(2(or 4)-C9-10-iso-alkylphenyl)phosphorothioate; and c) a 3-[[bis(2-methylpropoxy)phosphinothioyl]thio]-2-methylpropanoic acid; wherein the ratio by weight of component a) to component b) to component c) may vary within the ranges of 10:10:80 to 80:10:10 to 10:80: 10 by weight and the total content of A) in the composition is in the range between 0.01 and 0.1 % by weight as expressed by the total phosphorous content in the composition; B) At least one sulphur containing oil additive; C) Customary crank case oil additives selected from antioxidants, metal passivators, rust inhibitors, viscosity index enhancers, pour-point depressants, dispersants, detergents, and further extreme pressure additives; and D) Low sulphur oil of lubricating viscosity wherein the total sulphur content is not more than 0.3 weight%; with the proviso that the total amount of sulphur in the composition is less than 0.3 weight%. A) an additive mixture that consists of a) At least one compound having the chemical structure: wherein R represents C 3 -C 18 alkyl and R a and R b represent C 6 -C 20 alkyl; b) an O,O,O-tris(2(or 4)-C9-10-iso-alkylphenyl)phosphorothioate; and c) a 3-[[bis(2-methylpropoxy)phosphinothioyl]thio]-2-methylpropanoic acid; wherein the ratio by weight of component a) to component b) to component c) may vary within the ranges of 10:10:80 to 80:10:10 to 10:80: 10 by weight and the total content of A) in the composition is in the range between 0.01 and 0.1 % by weight as expressed by the total phosphorous content in the composition; a) At least one compound having the chemical structure: wherein R represents C 3 -C 18 alkyl and R a and R b represent C 6 -C 20 alkyl; b) an O,O,O-tris(2(or 4)-C9-10-iso-alkylphenyl)phosphorothioate; and c) a 3-[[bis(2-methylpropoxy)phosphinothioyl]thio]-2-methylpropanoic acid; B) At least one sulphur containing oil additive; C) Customary crank case oil additives selected from antioxidants, metal passivators, rust inhibitors, viscosity index enhancers, pour-point depressants, dispersants, detergents, and further extreme pressure additives; and D) Low sulphur oil of lubricating viscosity wherein the total sulphur content is not more than 0.3 weight%;
A method of formulating a skin care composition for use in cosmetics, the method comprising: (a) accessing with a computer a plurality of skin instances stored on at least one computer readable medium, wherein each instance is associated with a perturbagen and wherein each instance comprises an ordered list comprising a plurality of identifiers representing up-regulated genes and down-regulated genes; (b) accessing with a computer at least one unhealthy skin gene expression signature stored on the at least one computer readable medium, wherein the unhealthy skin gene expression signature comprises one or more lists comprising a plurality of identifiers representing a plurality of up-regulated genes and a plurality of down-regulated genes associated with acne, atopic dermatitis, eczema, dandruff, and psoriasis; (c) comparing with a computer the unhealthy skin gene expression signature to the plurality of the skin instances, wherein the comparison comprises comparing each identifier in the one or more gene expression signature lists with the position of the same identifier in the ordered lists for each of the plurality of instances; (d) assigning with a computer a connectivity score to each of the plurality of instances; (e) identifying a skin instance having a negative connectivity score or a positive connectivity score and (f) formulating a skin care composition comprising a dermatologically acceptable carrier and the perturbagen associated with the skin instance identified in step (e). (a) accessing with a computer a plurality of skin instances stored on at least one computer readable medium, wherein each instance is associated with a perturbagen and wherein each instance comprises an ordered list comprising a plurality of identifiers representing up-regulated genes and down-regulated genes; (b) accessing with a computer at least one unhealthy skin gene expression signature stored on the at least one computer readable medium, wherein the unhealthy skin gene expression signature comprises one or more lists comprising a plurality of identifiers representing a plurality of up-regulated genes and a plurality of down-regulated genes associated with acne, atopic dermatitis, eczema, dandruff, and psoriasis; (c) comparing with a computer the unhealthy skin gene expression signature to the plurality of the skin instances, wherein the comparison comprises comparing each identifier in the one or more gene expression signature lists with the position of the same identifier in the ordered lists for each of the plurality of instances; (d) assigning with a computer a connectivity score to each of the plurality of instances; (e) identifying a skin instance having a negative connectivity score or a positive connectivity score and (f) formulating a skin care composition comprising a dermatologically acceptable carrier and the perturbagen associated with the skin instance identified in step (e).