A micro-flow cytometer system (100, 200) for determination of a medical condition, the system comprising: a) a multi-sectioned disposable cartridge adapted to have manipulation and flow of samples occur therein, said cartridge adapted to receive a volume of a body fluid, said cartridge comprising a plurality of sections comprising: i. a body fluid aspiration section adapted to receive the body fluid directly or indirectly from a patient; ii. a pre-analytical sample processing section adapted to react at least one reactant with said bodily fluid to form a pre-treated sample; iii. a sample excitation/interaction section; iv. fluid conveying means for conveying said pre-treated sample from said pre-analytical sample processing section to said sample excitation/interaction section; and v. a spent sample disposal section; b) an optics unit comprising: i. an excitation illumination adapted to convey radiation via a first pathway to said pre-treated sample via a pathway; ii. an multi-spectral emission detector adapted to sample the spectral emission in spectral bands; and iii. an of a photon counter and an integrator; and c) a computer and a processor, wherein said excitation illumination and said multi-spectral emission detector are disposed on the same side of said cartridge; and wherein said optics unit is adapted to receive and detect via a portion of said pathway a plurality of spectrally distinct signals generated by interaction of said radiation and said pre-treated sample in said sample excitation/interaction section, wherein said computer is adapted to receive data related to said plurality of spectrally distinct signals and wherein said processor is adapted to process this data, thereby determining said medical condition. a) a multi-sectioned disposable cartridge adapted to have manipulation and flow of samples occur therein, said cartridge adapted to receive a volume of a body fluid, said cartridge comprising a plurality of sections comprising: i. a body fluid aspiration section adapted to receive the body fluid directly or indirectly from a patient; ii. a pre-analytical sample processing section adapted to react at least one reactant with said bodily fluid to form a pre-treated sample; iii. a sample excitation/interaction section; iv. fluid conveying means for conveying said pre-treated sample from said pre-analytical sample processing section to said sample excitation/interaction section; and v. a spent sample disposal section; i. a body fluid aspiration section adapted to receive the body fluid directly or indirectly from a patient; ii. a pre-analytical sample processing section adapted to react at least one reactant with said bodily fluid to form a pre-treated sample; iii. a sample excitation/interaction section; iv. fluid conveying means for conveying said pre-treated sample from said pre-analytical sample processing section to said sample excitation/interaction section; and v. a spent sample disposal section; b) an optics unit comprising: i. an excitation illumination adapted to convey radiation via a first pathway to said pre-treated sample via a pathway; ii. an multi-spectral emission detector adapted to sample the spectral emission in spectral bands; and iii. an of a photon counter and an integrator; and i. an excitation illumination adapted to convey radiation via a first pathway to said pre-treated sample via a pathway; ii. an multi-spectral emission detector adapted to sample the spectral emission in spectral bands; and iii. an of a photon counter and an integrator; and c) a computer and a processor,