A device for indirect temperature regulation of the brain of a human via a nasal cavity thereof, the device comprising: a membrane having a membrane surface area, a length, a center point with respect to the length, a width, and a center point with respect to the width, said membrane adapted to be arranged in contact with a surface of the nasal cavity, said membrane defining a closed volume and having the shape of the nasal cavity such that when in use, it expands and conforms to the nasal cavity, a first catheter extending along a distal-proximal axis, said first catheter having a first distal portion for introducing fluid into said closed volume and a first end portion, said distal portion having at least one first hole having a first total area, a second catheter extending along the distal-proximal axis, said second catheter having a second distal portion for removing fluid from said closed volume and a second end portion, said second distal portion having at least one second hole having a second area, and a distal bevel opening having a third area, at least one hole having a fourth area, and a distal slit positioned on the distal bevel opening, wherein the first distal portion protrudes in the closed volume further than the second distal portion, and wherein the first total area of the at least one first hole is smaller than the total area of the second area, the third area, and the fourth area combined, and wherein the membrane length extends along a portion of the distal-proximal axis such that the membrane surface area on a distal side of the center point is larger than the membrane surface area on a proximal side of the center point, and means for circulating said fluid into said volume via said at least one first hole on the first distal portion of said first catheter and out of said volume via said at least one second hole and distal opening on the second distal portion of said second catheter. a membrane having a membrane surface area, a length, a center point with respect to the length, a width, and a center point with respect to the width, said membrane adapted to be arranged in contact with a surface of the nasal cavity, said membrane defining a closed volume and having the shape of the nasal cavity such that when in use, it expands and conforms to the nasal cavity, a first catheter extending along a distal-proximal axis, said first catheter having a first distal portion for introducing fluid into said closed volume and a first end portion, said distal portion having at least one first hole having a first total area, a second catheter extending along the distal-proximal axis, said second catheter having a second distal portion for removing fluid from said closed volume and a second end portion, said second distal portion having at least one second hole having a second area, and a distal bevel opening having a third area, at least one hole having a fourth area, and a distal slit positioned on the distal bevel opening, wherein the first distal portion protrudes in the closed volume further than the second distal portion, and wherein the first total area of the at least one first hole is smaller than the total area of the second area, the third area, and the fourth area combined, and wherein the membrane length extends along a portion of the distal-proximal axis such that the membrane surface area on a distal side of the center point is larger than the membrane surface area on a proximal side of the center point, and means for circulating said fluid into said volume via said at least one first hole on the first distal portion of said first catheter and out of said volume via said at least one second hole and distal opening on the second distal portion of said second catheter.