A gynecological brachytherapy applicator (100, 200, 300, 400, 500, 700) comprising: an elongate body (102, 208, 306, 502, 702, 818) having a proximal end (110, 704, 802) and a distal end (108, 510, 804), a central lumen (104, 204, 302, 504, 708, 819) extending at least partially through the elongate body (102, 208, 306, 502, 702, 818), and at least one peripheral lumen (106, 206, 304, 710, 814) through which a radiation source may be advanced and which extends at least partially through the elongate body (102, 208, 306, 502, 702, 818); wherein the elongate body (102, 208, 306, 502, 702, 818) is made from foam; wherein the elongate body (102, 208, 306, 502, 702, 818) is conformable and has an initial expanded configuration of the elongate body (102, 208, 306, 502, 702, 818), an unexpanded configuration of the elongate body (102, 208, 306, 502, 702, 818) for advancement of the applicator (100, 200, 300, 400, 500, 700) to a target tissue, and an expanded deployed configuration of the elongate body (102, 208, 306, 502, 702, 818) after the applicator is positioned at the target tissue; wherein the elongate body (102, 208, 306, 502, 702, 818) is configured with a proximal port that is configured to connect with a vacuum source that withdraws air from the elongate body (102, 208, 306, 502, 702, 818) in the initial expanded configuration of the elongate body (102, 208, 306, 502, 702, 818) to provide the unexpanded configuration of the elongate body (102, 208, 306, 502, 702, 818); wherein the elongate body (102, 208, 306, 502, 702, 818) provides a collapsible and expandable matrix of support that is configured to stabilize a position and spacing of the at least one peripheral lumen (106, 206, 304, 710, 814) and the central lumen (104, 204, 302, 504, 708, 819) contained therein. an elongate body (102, 208, 306, 502, 702, 818) having a proximal end (110, 704, 802) and a distal end (108, 510, 804), a central lumen (104, 204, 302, 504, 708, 819) extending at least partially through the elongate body (102, 208, 306, 502, 702, 818), and at least one peripheral lumen (106, 206, 304, 710, 814) through which a radiation source may be advanced and which extends at least partially through the elongate body (102, 208, 306, 502, 702, 818); wherein the elongate body (102, 208, 306, 502, 702, 818) is made from foam; wherein the elongate body (102, 208, 306, 502, 702, 818) is conformable and has an initial expanded configuration of the elongate body (102, 208, 306, 502, 702, 818), an unexpanded configuration of the elongate body (102, 208, 306, 502, 702, 818) for advancement of the applicator (100, 200, 300, 400, 500, 700) to a target tissue, and an expanded deployed configuration of the elongate body (102, 208, 306, 502, 702, 818) after the applicator is positioned at the target tissue; wherein the elongate body (102, 208, 306, 502, 702, 818) is configured with a proximal port that is configured to connect with a vacuum source that withdraws air from the elongate body (102, 208, 306, 502, 702, 818) in the initial expanded configuration of the elongate body (102, 208, 306, 502, 702, 818) to provide the unexpanded configuration of the elongate body (102, 208, 306, 502, 702, 818); wherein the elongate body (102, 208, 306, 502, 702, 818) provides a collapsible and expandable matrix of support that is configured to stabilize a position and spacing of the at least one peripheral lumen (106, 206, 304, 710, 814) and the central lumen (104, 204, 302, 504, 708, 819) contained therein.