mhurhangee/ep-ind-claims huggingface dataset:
A method to detect an interaction between a target ligand and a moiety of interest using an adenylate cyclase enzyme and calmodulin (CaM) as interacting partners, said method comprising: i) expressing, in a suitable host cell: (a) a low number of molecules, typically between 1 and 10, of a first chimeric polypeptide containing AC, and (b) a low number of molecules, typically between 1 and 10, of a second chimeric polypeptide containing CaM, wherein said AC in said first chimeric polypeptide is a fragment or a mutated form of AC having 10 to 10 000 fold less affinity for CaM than the wild-type AC enzyme and said CaM in said second chimeric polypeptide is wild-type, or wherein said AC in said first chimeric polypeptide is wild-type and said CaM in said second chimeric polypeptide is a fragment or a mutated form of CaM having 10 to 10 000 fold less affinity for AC than the wild-type CaM, or wherein said AC in said first chimeric polypeptide is a fragment or a mutated form of AC having 10 to 10 000 fold less affinity for CaM than the wild-type AC enzyme, and wherein said CaM in said second chimeric polypeptide is a fragment or a mutated form of CaM having 10 to 10 000 fold less affinity for AC than the wild-type CaM, wherein said AC in said first chimeric polypeptide is fused to a moiety of interest and said CaM in said second chimeric polypeptide is fused to a target ligand, or conversely, and wherein, when said moiety of interest and said target ligand interact, the AC enzyme is activated, ii) detecting the activation of said AC enzyme in said cell. i) expressing, in a suitable host cell: (a) a low number of molecules, typically between 1 and 10, of a first chimeric polypeptide containing AC, and (b) a low number of molecules, typically between 1 and 10, of a second chimeric polypeptide containing CaM, wherein said AC in said first chimeric polypeptide is a fragment or a mutated form of AC having 10 to 10 000 fold less affinity for CaM than the wild-type AC enzyme and said CaM in said second chimeric polypeptide is wild-type, or wherein said AC in said first chimeric polypeptide is wild-type and said CaM in said second chimeric polypeptide is a fragment or a mutated form of CaM having 10 to 10 000 fold less affinity for AC than the wild-type CaM, or wherein said AC in said first chimeric polypeptide is a fragment or a mutated form of AC having 10 to 10 000 fold less affinity for CaM than the wild-type AC enzyme, and wherein said CaM in said second chimeric polypeptide is a fragment or a mutated form of CaM having 10 to 10 000 fold less affinity for AC than the wild-type CaM, wherein said AC in said first chimeric polypeptide is fused to a moiety of interest and said CaM in said second chimeric polypeptide is fused to a target ligand, or conversely, and wherein, when said moiety of interest and said target ligand interact, the AC enzyme is activated, (a) a low number of molecules, typically between 1 and 10, of a first chimeric polypeptide containing AC, and (b) a low number of molecules, typically between 1 and 10, of a second chimeric polypeptide containing CaM, ii) detecting the activation of said AC enzyme in said cell.
A computer program product for estimating a degree of ancestral relatedness between two individuals, the computer program product stored on a non-transitory computer readable medium and including instructions configured to cause a processor to execute steps comprising: receiving haplotype data for a population of individuals, the haplotype data including a plurality of genetic markers shared among the individuals; dividing the haplotype data into segment windows based on the genetic markers; for each individual in the population: based on the genetic markers, matching segments of the haplotype data that are identical between the individual and any other individual in the population, each matched segment having a first cM width exceeding a threshold cM width and being part of one or more of the segment windows; counting the matched segments in each segment window; estimating a weight associated with each segment window based on the count of matched segments in the associated segment window; calculating a weighted sum of per-window cM widths for each matched segment based on the first cM width and the weights associated with the segment windows of the matched segment; and estimating a degree of ancestral relatedness between two individuals based on the weighted sum of per-window cM widths of each matched segment between the two individuals. receiving haplotype data for a population of individuals, the haplotype data including a plurality of genetic markers shared among the individuals; dividing the haplotype data into segment windows based on the genetic markers; for each individual in the population: based on the genetic markers, matching segments of the haplotype data that are identical between the individual and any other individual in the population, each matched segment having a first cM width exceeding a threshold cM width and being part of one or more of the segment windows; counting the matched segments in each segment window; estimating a weight associated with each segment window based on the count of matched segments in the associated segment window; calculating a weighted sum of per-window cM widths for each matched segment based on the first cM width and the weights associated with the segment windows of the matched segment; and based on the genetic markers, matching segments of the haplotype data that are identical between the individual and any other individual in the population, each matched segment having a first cM width exceeding a threshold cM width and being part of one or more of the segment windows; counting the matched segments in each segment window; estimating a weight associated with each segment window based on the count of matched segments in the associated segment window; calculating a weighted sum of per-window cM widths for each matched segment based on the first cM width and the weights associated with the segment windows of the matched segment; and estimating a degree of ancestral relatedness between two individuals based on the weighted sum of per-window cM widths of each matched segment between the two individuals.
A method for provisioning an enrollee device to a Wi-Fi network by a configurator, the method comprising the enrollee device: transmitting a Device Provisioning Protocol, DPP, Configuration Request frame to the configurator, the DPP Configuration Request frame including an indication of band support of the enrollee device; receiving a DPP Configuration Response frame including: an indication of a Wi-Fi network that the enrollee device should attempt to join; and a sendConnStatus attribute; attempting to join the Wi-Fi network; and transmitting a DPP Status Query Result frame to the configurator, the DPP Status Query Result frame including a DPP Connection Status object indicating a result of the attempt to join the Wi-Fi network. transmitting a Device Provisioning Protocol, DPP, Configuration Request frame to the configurator, the DPP Configuration Request frame including an indication of band support of the enrollee device; receiving a DPP Configuration Response frame including: an indication of a Wi-Fi network that the enrollee device should attempt to join; and a sendConnStatus attribute; an indication of a Wi-Fi network that the enrollee device should attempt to join; and a sendConnStatus attribute; attempting to join the Wi-Fi network; and transmitting a DPP Status Query Result frame to the configurator, the DPP Status Query Result frame including a DPP Connection Status object indicating a result of the attempt to join the Wi-Fi network.
A polymer-siRNA delivery carrier with the following structure A-B, wherein a polymer A and a siRNA B are connected by using charge interaction and biodegradable covalent bonding at the same time, wherein the polymer A is chitosan or glycol chitosan having positive charge and functional group, wherein the siRNA B is a poly siRNA or multimer siRNA having a functional group at one end or both ends thereof and wherein when the siRNA B is a poly siRNA a plurality of siRNAs are connected by using degradable bonding.
A polypeptide comprising (i) a first amino acid sequence comprising at least one immunoglobulin single variable domain, which specifically binds to human IL-17F and to a heterodimer of human IL-17A and human IL-17F but does not specifically bind to human IL-17A; and (ii) a second amino acid sequence comprising at least one immunoglobulin single variable domain, which specifically binds to human IL-17A, to human IL-17F and to a heterodimer of human IL-17A and human IL-17F. (i) a first amino acid sequence comprising at least one immunoglobulin single variable domain, which specifically binds to human IL-17F and to a heterodimer of human IL-17A and human IL-17F but does not specifically bind to human IL-17A; and (ii) a second amino acid sequence comprising at least one immunoglobulin single variable domain, which specifically binds to human IL-17A, to human IL-17F and to a heterodimer of human IL-17A and human IL-17F.
A method of operating a power system, the method comprising: providing power to a first bus from a power source; detecting a loss of the power source; responsive to detecting the loss of the power source, disconnecting the first bus from a second bus that connects the first bus to an uninterruptible power supply UPS and a load; generating a voltage on the second bus using the UPS to thereby provide power from the UPS to the load; transitioning a generator to a desired output state concurrent with generating the voltage on the second bus using the UPS; and coupling the generator to the second bus via the first bus responsive to the generator attaining the desired output state to enable power transfer from the generator to the UPS and the load. providing power to a first bus from a power source; detecting a loss of the power source; responsive to detecting the loss of the power source, disconnecting the first bus from a second bus that connects the first bus to an uninterruptible power supply UPS and a load; generating a voltage on the second bus using the UPS to thereby provide power from the UPS to the load; transitioning a generator to a desired output state concurrent with generating the voltage on the second bus using the UPS; and coupling the generator to the second bus via the first bus responsive to the generator attaining the desired output state to enable power transfer from the generator to the UPS and the load. detecting a loss of the power source; responsive to detecting the loss of the power source, disconnecting the first bus from a second bus that connects the first bus to an uninterruptible power supply UPS and a load; generating a voltage on the second bus using the UPS to thereby provide power from the UPS to the load; transitioning a generator to a desired output state concurrent with generating the voltage on the second bus using the UPS; and coupling the generator to the second bus via the first bus responsive to the generator attaining the desired output state to enable power transfer from the generator to the UPS and the load.
A magnetic filter for a central heating system, the filter including a connection assembly, a canister, and a magnetic element, at least part of the connection assembly having a substantially cylindrical shape, the connection assembly including an inlet and an outlet for connection to a central heating circuit, the inlet and outlet being provided as ports extending from either side of the connection assembly substantially in line with each other; the canister having an interior separation chamber which is fluidly connected with the inlet and outlet for allowing fluid to flow into the inlet, through the separation chamber, and out of the outlet; and the magnetic element being removably positionable on the outside of the canister, the canister and the connection assembly forming a sealed flow path comprising the inlet, the interior separation chamber and the outlet, characterised in that the canister is in the form of a shell having unbroken walls (14a, 14b) and a single opening in the form of an open end, the canister being made for example from stainless steel, and the connection assembly further including two identical fitments (28a, 28b), one being provided with an air bleed fitting and the other being provided with a drain plug, the fitments being provided at substantially opposing points across the connection assembly and being offset 45 degrees from the inlet and outlet, the drain plug being configured as a closable drain outlet for draining fluid and magnetic particles from within the canister. at least part of the connection assembly having a substantially cylindrical shape, the connection assembly including an inlet and an outlet for connection to a central heating circuit, the inlet and outlet being provided as ports extending from either side of the connection assembly substantially in line with each other; the canister having an interior separation chamber which is fluidly connected with the inlet and outlet for allowing fluid to flow into the inlet, through the separation chamber, and out of the outlet; and the magnetic element being removably positionable on the outside of the canister, the canister and the connection assembly forming a sealed flow path comprising the inlet, the interior separation chamber and the outlet, characterised in that the canister is in the form of a shell having unbroken walls (14a, 14b) and a single opening in the form of an open end, the canister being made for example from stainless steel, and the connection assembly further including two identical fitments (28a, 28b), one being provided with an air bleed fitting and the other being provided with a drain plug, the fitments being provided at substantially opposing points across the connection assembly and being offset 45 degrees from the inlet and outlet, the drain plug being configured as a closable drain outlet for draining fluid and magnetic particles from within the canister.
Sliding block (40, 42, 44) for a torsional vibration damper, with a first surface section which, in the installation state, faces an adjacent spring element and is designed to be harder than another surface section of the sliding block (40, 42, 44), and with a basic body which consists of a basic material, wherein the first surface section is formed by at least one insert (78, 80, 82, 84, 86, 88, 90) which is designed to be harder than the basic material, characterized in that the first surface section is formed by at least two elongate inserts (86, 88) which are spaced apart from one another and project, and on which a spring element can be supported in a centering manner in the radial direction, or by a plate-like insert (78; 84) which is curved in a way ensuring a large-area radial support of a spring element.
An information reporting method, performed by a terminal, characterized in that the information reporting method comprises: when the terminal is in a discontinuous reception, DRX, mode and the terminal receives a first reference signal at least once in an active time no later than a channel state information, CSI, reference resource, performing a CSI measurement based on the first reference signal to obtain a CSI report, wherein the first reference signal comprises at least one of a CSI reference signal, CSI-RS, for channel measurement, a CSI-RS for interference measurement, a CSI-interference measurement, IM, for interference measurement, a CSI reference signals, CSI-RS, or a synchronization signal block, SSB, for reference signal receiving power, RSRP, measurement; determining, according to first information, whether the terminal in an inactive time reports the CSI report obtained through the CSI measurement; wherein the first information is configured to indicate allowing the terminal in the inactive time to report the CSI report at a CSI report instant. when the terminal is in a discontinuous reception, DRX, mode and the terminal receives a first reference signal at least once in an active time no later than a channel state information, CSI, reference resource, performing a CSI measurement based on the first reference signal to obtain a CSI report, wherein the first reference signal comprises at least one of a CSI reference signal, CSI-RS, for channel measurement, a CSI-RS for interference measurement, a CSI-interference measurement, IM, for interference measurement, a CSI reference signals, CSI-RS, or a synchronization signal block, SSB, for reference signal receiving power, RSRP, measurement; determining, according to first information, whether the terminal in an inactive time reports the CSI report obtained through the CSI measurement; wherein the first information is configured to indicate allowing the terminal in the inactive time to report the CSI report at a CSI report instant.
A method (200; 300), comprising: accessing (210; 310) a venue map associated with a venue; accessing (220; 320) a survey plan associated with the venue map, where the survey plan includes a survey path defined by a starting logical survey point and an ending logical survey point, where a logical survey point comprises a unique co-ordinate free identifier, a description of a recognizable location in the venue, and a co-ordinate configured to register the logical survey point relative to the venue map; providing (230; 330) the survey plan to a surveyor; receiving (240; 340) a sensor fingerprint at a sensor reading point along the survey path travelled by the surveyor; producing (250; 350) a sensor reading point data structure based, at least in part, on the sensor fingerprint, the sensor reading point, and the starting logical survey point; creating (260; 360) a registered survey point by registering the sensor reading point data structure with the venue map; and updating (270; 370) a fingerprint observation data store with the registered survey point. accessing (210; 310) a venue map associated with a venue; accessing (220; 320) a survey plan associated with the venue map, where the survey plan includes a survey path defined by a starting logical survey point and an ending logical survey point, where a logical survey point comprises a unique co-ordinate free identifier, a description of a recognizable location in the venue, and a co-ordinate configured to register the logical survey point relative to the venue map; providing (230; 330) the survey plan to a surveyor; receiving (240; 340) a sensor fingerprint at a sensor reading point along the survey path travelled by the surveyor; producing (250; 350) a sensor reading point data structure based, at least in part, on the sensor fingerprint, the sensor reading point, and the starting logical survey point; creating (260; 360) a registered survey point by registering the sensor reading point data structure with the venue map; and updating (270; 370) a fingerprint observation data store with the registered survey point.
A freezer cabinet for cold storage and showcasing of foods in a sales room, comprising a cooling chamber surrounded by stationary housing walls including a front wall, a rear wall, sidewalls, and a bottom wall, the chamber being accessible from a user-side front edge via a housing opening at a top side thereof, which, in the closed state, is covered by a cover unit having a lid part that adjoins the user-side edge and can be moved in a forward/backward direction and a stationary rear lid part that is positioned away from the user-side edge, wherein, to open up, the front lid part, arranged in front of the rear lid part in the closed state, and/or a middle lid part (20, 30) can be pushed at least partially over the rear lid part, characterized in that the front lid part is provided, in the front and rear regions thereof, laterally on both sides, with front and rear guide pins (11, 12) that protrude laterally over the edges, which guide pins engage with upper guide rails provided on both sides, and the upper guide rails have an upper retaining bar that has at least one respective gap through which the guide pins (11, 12) can be inserted and guided out when the front lid part is in a corresponding sliding position.
A method for producing a paperboard comprising the steps of; - providing a furnish comprising cellulosic fibers, - applying the furnish on at least one wire to form a web, - dewatering the web on said at least one wire by subjecting the web to a pressure above 150 kPa without the use of a press roll nip wherein the web comprises a first and second side and the dewatering is done from both sides of the web and thereafter - pressing the dewatered web to form a paperboard. - providing a furnish comprising cellulosic fibers, - applying the furnish on at least one wire to form a web, - dewatering the web on said at least one wire by subjecting the web to a pressure above 150 kPa without the use of a press roll nip wherein the web comprises a first and second side and the dewatering is done from both sides of the web and thereafter - pressing the dewatered web to form a paperboard.
A cascaded harmonic generator for cascaded optical harmonic generation from an optical beam provided by a laser source and travelling along an optical path of the cascaded harmonic generator, comprising: a lower harmonic generator to generate a lower harmonic optical beam based on a residual beam associated with the optical beam; and a higher harmonic generator to generate a higher harmonic optical beam based on the lower harmonic optical beam and the optical beam, the higher harmonic generator being positioned in the optical path upstream from the lower harmonic generator; where the optical beam comprises pulses having a pulse duration shorter than a harmonic generator delay time required for the pulses to travel along the optical path; where the harmonic generator delay time, associated with the optical path, is an integer multiple of a laser source round-trip time, such that, at the higher harmonic generator, a first fluctuation in the optical beam is synchronized with a second fluctuation in the lower harmonic optical beam, the integer multiple being equal to or greater than 2. a lower harmonic generator to generate a lower harmonic optical beam based on a residual beam associated with the optical beam; and a higher harmonic generator to generate a higher harmonic optical beam based on the lower harmonic optical beam and the optical beam, the higher harmonic generator being positioned in the optical path upstream from the lower harmonic generator; where the optical beam comprises pulses having a pulse duration shorter than a harmonic generator delay time required for the pulses to travel along the optical path; where the harmonic generator delay time, associated with the optical path, is an integer multiple of a laser source round-trip time, such that, at the higher harmonic generator, a first fluctuation in the optical beam is synchronized with a second fluctuation in the lower harmonic optical beam, the integer multiple being equal to or greater than 2.
A fusion protein comprising an interleukin-4 (IL-4) receptor binding protein and a pro-apoptotic Bcl-2 family polypeptide, wherein the IL-4 receptor binding protein is a mutant IL-4 or IL-13 selective for binding to a Type I or a Type II IL-4R, and wherein the pro-apoptotic Bcl-2 family polypeptide comprises a BH3 domain, and wherein the pro-apoptotic Bcl-2 family polypeptide is Bad, and wherein the fusion protein is capable of inhibiting cell survival, inhibiting cell proliferation, or enhancing cell death or apoptosis of a target cell expressing an IL-4 receptor (IL-4R).