A robotic catheter procedure system configured to be operated in conjunction with a medical imaging system comprising: a bedside system comprising an actuating mechanism (50, 52, 54) configured to engage and to impart movement to a percutaneous device (58, 60, 64); and a workstation, the workstation comprising: a user interface; a control system configured to be operatively coupled to the user interface, the bedside system, and the medical imaging system, the control system responsive to a first input and to a second input, wherein the user interface receives the second input from a user, the control system configured to generate: a first control signal to the medical imaging system based on the first input, wherein the medical imaging system captures at least one image in response to the first control signal; and a second control signal to the actuating mechanism (50, 52, 54) based on the second input, the actuating mechanism causing movement of the percutaneous device in response to the second control signal; characterized in that the user interface includes a control, wherein the first input is an initial interaction with the control by a user and further in that the control system is configured to generate the second control signal after a predetermined time following generation of the first control signal. a bedside system comprising an actuating mechanism (50, 52, 54) configured to engage and to impart movement to a percutaneous device (58, 60, 64); and a workstation, the workstation comprising: a user interface; a control system configured to be operatively coupled to the user interface, the bedside system, and the medical imaging system, the control system responsive to a first input and to a second input, wherein the user interface receives the second input from a user, the control system configured to generate: a first control signal to the medical imaging system based on the first input, wherein the medical imaging system captures at least one image in response to the first control signal; and a second control signal to the actuating mechanism (50, 52, 54) based on the second input, the actuating mechanism causing movement of the percutaneous device in response to the second control signal; a user interface; a control system configured to be operatively coupled to the user interface, the bedside system, and the medical imaging system, the control system responsive to a first input and to a second input, wherein the user interface receives the second input from a user, the control system configured to generate: a first control signal to the medical imaging system based on the first input, wherein the medical imaging system captures at least one image in response to the first control signal; and a second control signal to the actuating mechanism (50, 52, 54) based on the second input, the actuating mechanism causing movement of the percutaneous device in response to the second control signal; a first control signal to the medical imaging system based on the first input, wherein the medical imaging system captures at least one image in response to the first control signal; and a second control signal to the actuating mechanism (50, 52, 54) based on the second input, the actuating mechanism causing movement of the percutaneous device in response to the second control signal; the user interface includes a control, wherein the first input is an initial interaction with the control by a user and further in that the control system is configured to generate the second control signal after a predetermined time following generation of the first control signal.