An audio processing device, comprising: a handheld body configured to be selectively held to either one of a first side of a speaker's face and a second side of the speaker's face that is different than the first side of the speaker's face; an ambient sound microphone (104, 522) positioned on the handheld body to detect ambient sound and configured to produce an ambient sound signal based upon detected ambient sound; a voice microphone (106, 520) positioned asymmetrically on the handheld body relative to a centerline of the handheld body as the handheld body is held to the speaker's face, the voice microphone being located at a farther distance from a speaker's mouth when the handheld body is held to the first side of the speaker's face than when held to the second side of the speaker's face, the voice microphone configured to produce a voice signal; and an adaptive sound cancellation processor, communicatively coupled to the ambient sound microphone and the voice microphone, characterised by means (748, 754) to provide an orientation indication indicating that an expected orientation of the handheld body is in one of the first side of the speaker's face and the second side of the speaker's face; and the adaptive sound cancellation processor being configured to: receive the orientation indication; and adaptively reduce ambient sound from the voice signal by applying, when the orientation indication indicates the expected orientation is the first side of the speaker's face, a first sound cancellation algorithm configuration selected to process voice signals with first signal-to-noise ratio, and applying, when the orientation indication indicates the expected orientation is the second side of the speaker's face, a second sound cancellation algorithm configuration selected to process voice signals with a second signal-to-noise ratio, where the first signal-to-noise ratio is lower than the second signal-to-noise ratio. a handheld body configured to be selectively held to either one of a first side of a speaker's face and a second side of the speaker's face that is different than the first side of the speaker's face; an ambient sound microphone (104, 522) positioned on the handheld body to detect ambient sound and configured to produce an ambient sound signal based upon detected ambient sound; a voice microphone (106, 520) positioned asymmetrically on the handheld body relative to a centerline of the handheld body as the handheld body is held to the speaker's face, the voice microphone being located at a farther distance from a speaker's mouth when the handheld body is held to the first side of the speaker's face than when held to the second side of the speaker's face, the voice microphone configured to produce a voice signal; and an adaptive sound cancellation processor, communicatively coupled to the ambient sound microphone and the voice microphone, receive the orientation indication; and adaptively reduce ambient sound from the voice signal by applying, when the orientation indication indicates the expected orientation is the first side of the speaker's face, a first sound cancellation algorithm configuration selected to process voice signals with first signal-to-noise ratio, and applying, when the orientation indication indicates the expected orientation is the second side of the speaker's face, a second sound cancellation algorithm configuration selected to process voice signals with a second signal-to-noise ratio, where the first signal-to-noise ratio is lower than the second signal-to-noise ratio.