Device (10, 30, 50, 60, 80), which is embodied to be used for lysing a sample to be subjected to lysis, the device (10, 30, 50, 60, 80) comprising a holding element (101, 301, 501, 601, 801), which is embodied as a membrane and/or is completely or at least partly elastic and deformable, the holding element (101, 301, 501, 601, 801) being embodied as: - to hold an energy-transmitting element at least in part such that the holding element (101, 301, 501, 601, 801) lies around the held part of the energy-transmitting element and envelops the held part of the energy-transmitting element and/or that the holding element (101, 301, 501, 601, 801) lies against the held part of the energy-transmitting element; and - to cause lysis with the energy-transmitting element, the held part of which is enveloped by the holding element (101, 301, 501, 601, 801) and/or against the held part of which the holding element (101, 301, 501, 601, 801) lies, when the holding element (101, 301, 501, 601, 801), which envelops the held part of the energy-transmitting element and/or which lies against the held part of the energy-transmitting element, is immersed into the sample to be subjected to lysis or is in contact with the sample to be subjected to lysis, wherein the holding element (101, 301, 501, 601, 801) is designed to at least partly hold the energy-transmitting element by means of one of the following options: - by applying external contact pressure on the energy-transmitting element; - by applying positive pressure in a lysis container (43, 50, 60) with the sample to be subjected to lysis; - by combined application of positive pressure around a lysis container (43, 50, 60) with the sample to be subjected to lysis and a counteracting force, applied from the outside, on the energytransmitting element; or - by applying negative pressure around the energy-transmitting element; and/or wherein, during the at least partial holding, the holding element (101, 301, 501, 601, 801) arches in the direction of the energy-transmitting element and establishes a gap-free or substantially gap-free contact with the held part of the energy-transmitting element. - to hold an energy-transmitting element at least in part such that the holding element (101, 301, 501, 601, 801) lies around the held part of the energy-transmitting element and envelops the held part of the energy-transmitting element and/or that the holding element (101, 301, 501, 601, 801) lies against the held part of the energy-transmitting element; and - to cause lysis with the energy-transmitting element, the held part of which is enveloped by the holding element (101, 301, 501, 601, 801) and/or against the held part of which the holding element (101, 301, 501, 601, 801) lies, when the holding element (101, 301, 501, 601, 801), which envelops the held part of the energy-transmitting element and/or which lies against the held part of the energy-transmitting element, is immersed into the sample to be subjected to lysis or is in contact with the sample to be subjected to lysis, wherein the holding element (101, 301, 501, 601, 801) is designed to at least partly hold the energy-transmitting element by means of one of the following options: - by applying external contact pressure on the energy-transmitting element; - by applying positive pressure in a lysis container (43, 50, 60) with the sample to be subjected to lysis; - by combined application of positive pressure around a lysis container (43, 50, 60) with the sample to be subjected to lysis and a counteracting force, applied from the outside, on the energytransmitting element; or - by applying negative pressure around the energy-transmitting element; and/or wherein, during the at least partial holding, the holding element (101, 301, 501, 601, 801) arches in the direction of the energy-transmitting element and establishes a gap-free or substantially gap-free contact with the held part of the energy-transmitting element.