A robotic surgery system, comprising: a fluoroscopic imaging system comprising a source element and a detector element; a base configured to be fixed relative to an operating room; a robotic arm coupled to the base, wherein the robotic arm comprises a mounting fixture coupled to the first element of the fluoroscopic imaging system, wherein the first element is one of the source element and the detector element; a second element of the fluoroscopic imaging system, wherein the second element is the other of the source element and the detector element, the second element configured to be repositionable relative to the first element of the fluoroscopic imaging system and relative to a patient tissue structure such that the patient tissue structure may be positioned between the first and second elements of the fluoroscopic imaging system; a controller operatively coupled to the first robotic arm, the controller configured to receive signals from a sensing system operatively coupled to the controller, the sensing system configured to detect motion of one or more sensor elements coupled to each of the first and second elements of the fluoroscopic imaging system and the controller further configured to determine a relative spatial positioning between each of the first and second elements of the fluoroscopic imaging system; and an input device operatively coupled to the controller and configured to allow for an operator to select a desired geometric relationship between the first and second elements relative to the patient tissue structure; characterized in that the controller is further configured to guide a user to alignment of the first and second elements in the desired geometric relationship. a fluoroscopic imaging system comprising a source element and a detector element; a base configured to be fixed relative to an operating room; a robotic arm coupled to the base, wherein the robotic arm comprises a mounting fixture coupled to the first element of the fluoroscopic imaging system, a second element of the fluoroscopic imaging system, wherein the second element is the other of the source element and the detector element, the second element configured to be repositionable relative to the first element of the fluoroscopic imaging system and relative to a patient tissue structure such that the patient tissue structure may be positioned between the first and second elements of the fluoroscopic imaging system; a controller operatively coupled to the first robotic arm, the controller configured to receive signals from a sensing system operatively coupled to the controller, the sensing system configured to detect motion of one or more sensor elements coupled to each of the first and second elements of the fluoroscopic imaging system and the controller further configured to determine a relative spatial positioning between each of the first and second elements of the fluoroscopic imaging system; and an input device operatively coupled to the controller and configured to allow for an operator to select a desired geometric relationship between the first and second elements relative to the patient tissue structure; characterized in that the controller is further configured to guide a user to alignment of the first and second elements in the desired geometric relationship.