A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: Ar 1 is aryl substituted with 1-2 R 1a and 1-2 R 1b or monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and substituted with 1-2 R 1a and 1-2 R 1b; Ar 2 is aryl substituted with 1-4 R 2a or 6-membered heteroaryl with 1-2 nitrogen atoms, and substituted with 1-4 R 2a; Ar 3 is aryl substituted with 1-4 R 3a or monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and substituted with 1-4 R 3a; R 1a is hydrogen or halo; R 1b is halo, haloalkyl, alkoxy, or haloalkoxy; R 2a is hydrogen, cyano, halo, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, alkoxy, or haloalkoxy; alternatively, two adjacent R 2a groups are taken together with the carbon atoms to which they are attached to form a heterocycle with 1-4 heteroatoms selected from nitrogen, oxygen, and sulfur; R 3a is cyano, halo, alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, (R 1 R 2 N)alkyl, R 1 R 2 N, alkylC (R 2)Nalkyl, (alkyl) 2 P, (alkoxy) 2 P, (alkoxy)(alkyl) P, (alkyl) (NR 1)S, alkylSO 2, or alkylSO 2 NH; alternatively, two adjacent R 3a groups are taken together with the carbon atoms to which they are attached to form a heterocycle with1-4 heteroatoms selected from nitrogen, oxygen, and sulfur; R 4a or R 4b is independently hydrogen, alkyl, alkoxy, hydroxylalkyl, alkoxyalkyl, or haloalkoxy; alternatively, R 4a and R 4b together with the carbon atom they are both attached to form a C 3-6 cycloalkyl; R 5a or R 5b is independently hydrogen, alkyl, hydroxylalkyl, alkoxyalkyl or haloalkoxyl; R 1 is hydrogen or alkyl; and R 2 is hydrogen or alkyl; or R 1 R 2 N taken together is azetidinyl, oxazolyl pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, and oxo; alkyl means a straight or branched alkyl group composed of 1 to 6 carbons; cycloalkyl means a monocyclic ring system composed of 3 to 7 carbons. Ar 1 is aryl substituted with 1-2 R 1a and 1-2 R 1b or monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and substituted with 1-2 R 1a and 1-2 R 1b; Ar 2 is aryl substituted with 1-4 R 2a or 6-membered heteroaryl with 1-2 nitrogen atoms, and substituted with 1-4 R 2a; Ar 3 is aryl substituted with 1-4 R 3a or monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and substituted with 1-4 R 3a; R 1a is hydrogen or halo; R 1b is halo, haloalkyl, alkoxy, or haloalkoxy; R 2a is hydrogen, cyano, halo, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, alkoxy, or haloalkoxy; alternatively, two adjacent R 2a groups are taken together with the carbon atoms to which they are attached to form a heterocycle with 1-4 heteroatoms selected from nitrogen, oxygen, and sulfur; R 3a is cyano, halo, alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, (R 1 R 2 N)alkyl, R 1 R 2 N, alkylC (R 2)Nalkyl, (alkyl) 2 P, (alkoxy) 2 P, (alkoxy)(alkyl) P, (alkyl) (NR 1)S, alkylSO 2, or alkylSO 2 NH; alternatively, two adjacent R 3a groups are taken together with the carbon atoms to which they are attached to form a heterocycle with1-4 heteroatoms selected from nitrogen, oxygen, and sulfur; R 4a or R 4b is independently hydrogen, alkyl, alkoxy, hydroxylalkyl, alkoxyalkyl, or haloalkoxy; alternatively, R 4a and R 4b together with the carbon atom they are both attached to form a C 3-6 cycloalkyl; R 5a or R 5b is independently hydrogen, alkyl, hydroxylalkyl, alkoxyalkyl or haloalkoxyl; R 1 is hydrogen or alkyl; and R 2 is hydrogen or alkyl; or R 1 R 2 N taken together is azetidinyl, oxazolyl pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, and oxo;