mhurhangee/ep-ind-claims huggingface dataset:
A system for humidifying gases, the system comprising: a body, extending along a first longitudinal axis from a first face to a second face; a first lumen, at the first face, through which fluid enters the body; a second lumen, at the first face, through which the fluid exits the body; and a first non-porous membrane, inside the body, extending from the first face to the second face, wherein gas moving through the first non-porous membrane is humidified by the fluid, wherein the first non-porous membrane is permeable to the gas, and characterized in that the first non-porous membrane comprises a plurality of large-diameter fibers, each of the plurality of fibers having a diameter of about 0.5 millimeters to about 2.0 millimeters. a body, extending along a first longitudinal axis from a first face to a second face; a first lumen, at the first face, through which fluid enters the body; a second lumen, at the first face, through which the fluid exits the body; and a first non-porous membrane, inside the body, extending from the first face to the second face, wherein gas moving through the first non-porous membrane is humidified by the fluid, wherein the first non-porous membrane is permeable to the gas, and characterized in that the first non-porous membrane comprises a plurality of large-diameter fibers, each of the plurality of fibers having a diameter of about 0.5 millimeters to about 2.0 millimeters.
Process for the preparation of Rilpivirine or a pharmaceutically acceptable salt or solvate thereof comprising the following steps in the following order: a) preparing a compound of formula II: wherein A is an amine protecting group selected from alkyloxycarbonyl, arylalkyloxycarbonyl, alkylcarbonyl, arylsulfonyl, alkylsulfonyl, haloalkylsulfonyl, alkyl, alkenyl and arylalkyl, b) reacting said compound of formula II with a 2,4-dihalogenopyrimidine in the presence of a base to obtain compound of formula III: wherein A is an amine protecting group selected from alkyloxycarbonyl, arylalkyloxycarbonyl, alkylcarbonyl, arylsulfonyl, alkylsulfonyl, haloalkylsulfonyl, alkyl, alkenyl and arylalkyl and X is a halogen, c) reacting said compound of formula III with 4-aminobenzonitrile in the presence of an acid, and d) cleaving the group A, wherein steps a), b, and c) are carried out successively in this order and step d) is carried out concomitantly with step c) or after step c). a) preparing a compound of formula II: wherein A is an amine protecting group selected from alkyloxycarbonyl, arylalkyloxycarbonyl, alkylcarbonyl, arylsulfonyl, alkylsulfonyl, haloalkylsulfonyl, alkyl, alkenyl and arylalkyl, b) reacting said compound of formula II with a 2,4-dihalogenopyrimidine in the presence of a base to obtain compound of formula III: wherein A is an amine protecting group selected from alkyloxycarbonyl, arylalkyloxycarbonyl, alkylcarbonyl, arylsulfonyl, alkylsulfonyl, haloalkylsulfonyl, alkyl, alkenyl and arylalkyl and X is a halogen, c) reacting said compound of formula III with 4-aminobenzonitrile in the presence of an acid, and d) cleaving the group A,
Composition for use in the prevention and/or treatment of a liver disease in a mammal, the composition comprising an active agent, said active agent containing the amino acids leucine, isoleucine, valine, threonine, lysine and the carboxylic acids citric acid, succinic acid, malic acid.
A method for transmitting a pilot signal with multiplexed unicast and multicast transmissions, comprising: classifying one or more modes of transmission; selecting a longer cyclic prefix duration for at least one sub-frame in accordance with the classified one or more modes; and multiplexing pilot information and user data in the at least one sub-frame based at least in part on the longer cyclic prefix duration, wherein single frequency network, SFN, data and SFN reference symbols are sent on symbols within the at least one sub-frame and wherein unicast reference symbols are not sent in the second slot of the at least one sub-frame, said method characterized in that a gap between tones occupied by unicast reference symbols of the first symbol of the slot depends on a cyclic prefix duration. classifying one or more modes of transmission; selecting a longer cyclic prefix duration for at least one sub-frame in accordance with the classified one or more modes; and multiplexing pilot information and user data in the at least one sub-frame based at least in part on the longer cyclic prefix duration, wherein single frequency network, SFN, data and SFN reference symbols are sent on symbols within the at least one sub-frame and wherein unicast reference symbols are not sent in the second slot of the at least one sub-frame, said method characterized in that a gap between tones occupied by unicast reference symbols of the first symbol of the slot depends on a cyclic prefix duration.
A wireless communication system that forms a communication network using a plurality of communication terminals, wherein the plurality of communication terminals include a master unit, a plurality of slave units connected to the master unit and constituting the communication network and a plurality of information acquiring devices acquiring predetermined information and connected to the plurality of slave units, the master unit and the plurality of slave units communicate with each other according to a communication schedule divided into a plurality of time slots, each of the plurality of slave units is assigned with a specific time slot in the plurality of time slots, the master unit communicates, in the specific time slot, with one of the slave units corresponding to the specific time slot according to the communication schedule, in the specific time slot assigned to the slave unit that communicates with the master unit through another slave unit, communication between the master unit and the slave unit is performed through the another slave unit, each of the slave units includes a communication controller that switches a state between an active state and a sleep state with a smaller power consumption than that in the active state, communicates with at least the master unit, another slave unit or one of the plurality of information acquiring devices in the active state, temporarily stores the information acquired by communicating with the one of the plurality of information acquiring devices,, and transmits the stored information to the higher-layer communication terminal in the specific time slot, and a slot determiner that determines arrival of the specific time slot and arrival of a relay time slot, the relay time slot being a time slot assigned to another lower-layer slave unit, the communication controller changes to the active state and performs a predetermined communication process if the slot determiner determines arrival of the specific time slot, and changes to the active state and performs a communication relay process between the lower-layer slave unit and another higher-layer slave unit if the slot determiner determines arrival of the relay time slot, and each of the plurality of information acquiring devices switches a state between an active state and a sleep state with a smaller power consumption than that in the active state, changes to the active state in accordance with the specific time slot of the slave unit connected to the each of the plurality of information acquiring devices and transmits the information to the slave unit, and changes to the sleep state after completion of transmission of the information to the slave unit.
Process for the preparation of a pyrazole carboxylic acid derivative of the formula wherein R 1 is C 1-7 -alkyl and R 3 is C 1-7 -alkyl which is optionally substituted with halogen or C 1-4 -alkoxy comprising the steps, a) reacting an oxoacetate of the formula wherein R 2 is C 1-7 -alkyl and X is halogen with an acrylate of the formula wherein R 1 is as above and R 4 and R 5 are C 1-7 -alkyl in the presence of a base to form an aminomethylene succinic acid ester of the formula wherein R 1, R 2, R 4 and R 5 are as above; b) coupling the aminomethylene succinic acid ester of the formula IV with an N-protected hydrazine derivative of formula wherein R 3 is as above and R 6 is an amino protecting group to form the hydrazinomethylene succinic acid ester of the formula wherein R 1, R 2, R 3 and R 6 are as above; c) ring closing the hydrazinomethylene succinic acid ester of formula VI under acidic conditions to form the pyrazole dicarboxylic acid ester of the formula wherein R 1, R 2 and R 3 are as above and; d) hydrolyzing the pyrazole dicarboxylic acid ester of the formula VII in 3-position with a base to form the pyrazole carboxylic acid derivative of the formula I. a) reacting an oxoacetate of the formula wherein R 2 is C 1-7 -alkyl and X is halogen with an acrylate of the formula wherein R 1 is as above and R 4 and R 5 are C 1-7 -alkyl in the presence of a base to form an aminomethylene succinic acid ester of the formula wherein R 1, R 2, R 4 and R 5 are as above; b) coupling the aminomethylene succinic acid ester of the formula IV with an N-protected hydrazine derivative of formula wherein R 3 is as above and R 6 is an amino protecting group to form the hydrazinomethylene succinic acid ester of the formula wherein R 1, R 2, R 3 and R 6 are as above; c) ring closing the hydrazinomethylene succinic acid ester of formula VI under acidic conditions to form the pyrazole dicarboxylic acid ester of the formula wherein R 1, R 2 and R 3 are as above and; d) hydrolyzing the pyrazole dicarboxylic acid ester of the formula VII in 3-position with a base to form the pyrazole carboxylic acid derivative of the formula I.
A panning stereo endoscope which maintains an up-down orientation as the stereo endoscope pans an operative field, the panning stereo endoscope comprising: - a shaft having an axis; - first and second optical channels extending along the shaft, each of the first and second optical channels having an off-axis direction of view; and - an actuating mechanism carried by the shaft and adapted to (i) synchronously rotate the first and second optical channels about their respective axes, and (ii) synchronously, inversely piston the first and second optical channels along their respective axes, characterized in that the actuating mechanism comprises a ring gear and a cam, the ring gear and the cam being connected so that they rotate in unison. - a shaft having an axis; - first and second optical channels extending along the shaft, each of the first and second optical channels having an off-axis direction of view; and - an actuating mechanism carried by the shaft and adapted to (i) synchronously rotate the first and second optical channels about their respective axes, and (ii) synchronously, inversely piston the first and second optical channels along their respective axes, characterized in that the actuating mechanism comprises a ring gear and a cam, the ring gear and the cam being connected so that they rotate in unison.
An ink discharge complementing method which complements an ink discharge defect of a defective nozzle, out of a plurality of nozzles of a discharge head, comprising: a gradation data acquisition step of obtaining gradation data representing a gradation value of each of a plurality of pixels constituting a print image; a conversion step of converting the gradation data into defect complemented gradation data by converting the gradation values of the gradation data, using a first conversion rule for the gradation values of the pixels corresponding to normal nozzles other than surrounding nozzles located around the defective nozzle and the defective nozzle, out of the plurality of nozzles, and a second conversion rule for the gradation values of the pixels corresponding to the surrounding nozzles; a shading correction step of performing a shading correction to correct a variation of an amount of the ink discharged from each of the plurality of nozzles for the defect complemented gradation data; a halftone step of generating discharge control data by performing a halftone process for the defect complemented gradation data having the shading correction performed therefor; and an image printing step of printing the print image on a printing medium by the ink discharged from the nozzles by driving the nozzles based on the discharge control data, the first conversion rule converting the gradation values of the pixels corresponding to the normal nozzles by a first rate lower than 100 %, and the second conversion rule converting the gradation values of the pixels corresponding to the surrounding nozzles by a second rate higher than the first rate. a gradation data acquisition step of obtaining gradation data representing a gradation value of each of a plurality of pixels constituting a print image; a conversion step of converting the gradation data into defect complemented gradation data by converting the gradation values of the gradation data, using a first conversion rule for the gradation values of the pixels corresponding to normal nozzles other than surrounding nozzles located around the defective nozzle and the defective nozzle, out of the plurality of nozzles, and a second conversion rule for the gradation values of the pixels corresponding to the surrounding nozzles; a shading correction step of performing a shading correction to correct a variation of an amount of the ink discharged from each of the plurality of nozzles for the defect complemented gradation data; a halftone step of generating discharge control data by performing a halftone process for the defect complemented gradation data having the shading correction performed therefor; and an image printing step of printing the print image on a printing medium by the ink discharged from the nozzles by driving the nozzles based on the discharge control data, the first conversion rule converting the gradation values of the pixels corresponding to the normal nozzles by a first rate lower than 100 %, and the second conversion rule converting the gradation values of the pixels corresponding to the surrounding nozzles by a second rate higher than the first rate.
A bicycle chainring for engagement with a drive chain provided with rollers, the bicycle chainring comprising: a plurality of teeth (2, 3) extending radially from a periphery of the chainring, wherein the plurality of teeth (2, 3) comprises a plurality of narrow teeth and a plurality of wide teeth, wherein each tooth (2, 3) comprises a front flank and a rear flank with respect to a drive direction and two opposing side surfaces, wherein at least one side surface of each wide tooth comprises a protrusion extending therefrom in an axial direction of the chainring, characterised in that each protrusion comprises a respective groove arranged halfway between a top land of the respective wide tooth and a root circle of the respective wide tooth, wherein the groove extends throughout the protrusion in a direction substantially parallel to the top land. a plurality of teeth (2, 3) extending radially from a periphery of the chainring, wherein the plurality of teeth (2, 3) comprises a plurality of narrow teeth and a plurality of wide teeth, wherein each tooth (2, 3) comprises a front flank and a rear flank with respect to a drive direction and two opposing side surfaces, wherein at least one side surface of each wide tooth comprises a protrusion extending therefrom in an axial direction of the chainring, characterised in that each protrusion comprises a respective groove arranged halfway between a top land of the respective wide tooth and a root circle of the respective wide tooth, wherein the groove extends throughout the protrusion in a direction substantially parallel to the top land.
Light source for industrial image processing for illuminating an image area, characterized in that the light source has at least one sensor and the at least one sensor is provided for capturing an actual relative position of the light source in relation to at least one predetermined reference point and/or at least one predetermined reference plane and that a comparison unit connected to the sensor is provided for comparing the actual relative position of the light source with a predetermined relative target position.
Method for producing or propagating an engineered bacteriophage, comprising the steps of: - providing a functional synthetic genome of an engineered bacteriophage being able to infect a target bacterium, - providing a recipient bacterium, - transforming said recipient bacterium with said functional synthetic genome in a transformation step, yielding a transformed recipient bacterium, - incubating said transformed recipient bacterium in a first incubation step, wherein said engineered bacteriophage is propagated within said transformed recipient bacterium, and - further incubating said transformed recipient bacterium or said propagated engineered bacteriophage released from said transformed recipient bacterium with a target bacterium in a second incubation step, wherein said propagated engineered bacteriophage infects said target bacterium and is further propagated within said target bacterium, wherein said recipient bacterium is a cell wall-deficient bacterium. - providing a functional synthetic genome of an engineered bacteriophage being able to infect a target bacterium, - providing a recipient bacterium, - transforming said recipient bacterium with said functional synthetic genome in a transformation step, yielding a transformed recipient bacterium, - incubating said transformed recipient bacterium in a first incubation step, wherein said engineered bacteriophage is propagated within said transformed recipient bacterium, and - further incubating said transformed recipient bacterium or said propagated engineered bacteriophage released from said transformed recipient bacterium with a target bacterium in a second incubation step, wherein said propagated engineered bacteriophage infects said target bacterium and is further propagated within said target bacterium,
Device for placing at least one prosthesis in a corporeal duct, said device comprising a distal end for receiving at least said prosthesis, said device comprising - a conforming assembly (20, 21) for maintaining the part of said prosthesis that is intended to be inserted into said corporeal duct in a radially compressed state so as to facilitate the insertion of said prosthesis part inside said corporeal duct, said conforming assembly (20, 21) being placed at said distal end, the portion of the device receiving the part of the prosthesis that is intended to be placed outside of the corporeal duct having a diameter that is at least equal to the diameter D of said corporeal duct such that the operator has a marker ensuring that only the sole part of the prosthesis that is radially compressed is inserted into said corporeal duct, - an actuating means for passing said conforming assembly (20, 21) between an active position wherein said assembly maintains the sole part of said prosthesis that is intended to be inserted into said corporeal duct in a radially compressed state and a rest position wherein said prosthesis part is in the initial configuration thereof, said device having a major axis, said conforming assembly (20, 21) comprising tabs that are disposed circumferentially about said major axis, said actuating means being a rigid ring capable of moving in translation, characterised in that each of said tabs comprises, on the outer surface thereof, a protrusion onto which the ring is engaged in order to move the end of each of said tabs towards the interior of said device. - a conforming assembly (20, 21) for maintaining the part of said prosthesis that is intended to be inserted into said corporeal duct in a radially compressed state so as to facilitate the insertion of said prosthesis part inside said corporeal duct, said conforming assembly (20, 21) being placed at said distal end, the portion of the device receiving the part of the prosthesis that is intended to be placed outside of the corporeal duct having a diameter that is at least equal to the diameter D of said corporeal duct such that the operator has a marker ensuring that only the sole part of the prosthesis that is radially compressed is inserted into said corporeal duct, - an actuating means for passing said conforming assembly (20, 21) between an active position wherein said assembly maintains the sole part of said prosthesis that is intended to be inserted into said corporeal duct in a radially compressed state and a rest position wherein said prosthesis part is in the initial configuration thereof, said device having a major axis, said conforming assembly (20, 21) comprising tabs that are disposed circumferentially about said major axis, said actuating means being a rigid ring capable of moving in translation, characterised in that each of said tabs comprises, on the outer surface thereof, a protrusion onto which the ring is engaged in order to move the end of each of said tabs towards the interior of said device.
A computer-implemented method of converting venous blood values to arterial blood values, said method comprising: a) providing values of measured and/or estimated arterial oxygenation selected from SO2 AM, SO2 AE or SpO2, b) measuring and/or estimating values of blood acid/base status in a blood sample selected from VBG M or VBG E, the blood sample being obtained from venous blood, c) converting the venous blood values by applying a mathematical model for deriving blood acid/base status and oxygenation status into estimated arterial blood values, ABG P, wherein, d1) if a value of measured and/or estimated arterial oxygenation value is below a corresponding venous oxygenation value, e) then estimating the said arterial oxygenation value with a replacement value being a function of the corresponding venous oxygenation value. a) providing values of measured and/or estimated arterial oxygenation selected from SO2 AM, SO2 AE or SpO2, b) measuring and/or estimating values of blood acid/base status in a blood sample selected from VBG M or VBG E, the blood sample being obtained from venous blood, c) converting the venous blood values by applying a mathematical model for deriving blood acid/base status and oxygenation status into estimated arterial blood values, ABG P, wherein, d1) if a value of measured and/or estimated arterial oxygenation value is below a corresponding venous oxygenation value, e) then estimating the said arterial oxygenation value with a replacement value being a function of the corresponding venous oxygenation value.
An in vitro method of identifying an individual afflicted with cancer as being suitable or not suitable for immunotherapy comprising: i) testing for the presence or absence of Duffy-null mutation in the genome of cells obtained from the individual, or the presence or absence of DARC protein on red blood cells from the individual; and ii) if the Duffy-null mutation is present in both alleles, or if no DARC protein is detected on red blood cells, identifying the individual as a RBC-DARC negative individual and therefore, as an individual not suitable for immunotherapy, and if the Duffy-null mutation is not present on one or both alleles, or if the RBCs express DARC protein, then identifying the individual as suitable for immunotherapy. i) testing for the presence or absence of Duffy-null mutation in the genome of cells obtained from the individual, or the presence or absence of DARC protein on red blood cells from the individual; and ii) if the Duffy-null mutation is present in both alleles, or if no DARC protein is detected on red blood cells, identifying the individual as a RBC-DARC negative individual and therefore, as an individual not suitable for immunotherapy, and if the Duffy-null mutation is not present on one or both alleles, or if the RBCs express DARC protein, then identifying the individual as suitable for immunotherapy.