mhurhangee/ep-ind-claims huggingface dataset:
A cell expressing a non-natural oligomeric protein, which comprises (i) an introduced gene which encodes an exogenous polypeptide that constitutes the non-natural oligomeric protein and that corresponds to an endogenous polypeptide constituting a natural oligomeric protein, and (ii) an siRNA inhibiting the expression of the endogenous polypeptide by RNA interference, wherein, when the expression of the endogenous polypeptide is not inhibited, the exogenous polypeptide and the endogenous polypeptide compete with each other for the formation of an oligomeric protein, whereas, when the expression of the endogenous polypeptide is inhibited, the competition between the exogenous polypeptide and the endogenous polypeptide is inhibited, wherein the expression of the endogenous polypeptide in the cell is inhibited by the siRNA, and the expression of the exogenous polypeptide is not inhibited by the siRNA, wherein a nucleotide sequence of the exogenous polypeptide is modified without changing an encoded amino acid sequence in a region which the siRNA acts on and which encodes the same amino acid sequence between the endogenous polypeptide and the exogenous polypeptide, and wherein the oligomeric protein is an antigen recognition receptor.
An image acquisition device for acquiring an image of an observation target by radiating structured illumination light, the image acquisition device comprising: a light source for outputting light; a spatial light modulator having a plurality of pixels two-dimensionally arranged and for modulating a phase of the light output from the light source for each of the plurality of pixels; an objective lens for radiating the modulated light to the observation target; a first optical system including a lens for focusing a illumination light from the spatial light modulator on the pupil of the objective lens; a photodetector for capturing an image of the light from the observation target; and a control unit for controlling an amount of phase modulation for each of the plurality of pixels in accordance with a phase pattern in which phase values corresponding to the plurality of pixels are two-dimensionally distributed, wherein the phase pattern is a phase pattern generated based on a predetermined basic phase pattern, wherein the basic phase pattern (31A-31J) includes a first region (32A-32J) in which the phase value continuously increases in a predetermined direction and a second region (33A-33J) in which the phase value continuously decreases in the predetermined direction and facing the first region (32A-32J) in the predetermined direction, and the basic phase pattern further includes a third region (34E-34J) in which the phase value is constant such that stripe-like illumination light in which gaps are formed at regular intervals on the stripes is generated. a light source for outputting light; a spatial light modulator having a plurality of pixels two-dimensionally arranged and for modulating a phase of the light output from the light source for each of the plurality of pixels; an objective lens for radiating the modulated light to the observation target; a first optical system including a lens for focusing a illumination light from the spatial light modulator on the pupil of the objective lens; a photodetector for capturing an image of the light from the observation target; and a control unit for controlling an amount of phase modulation for each of the plurality of pixels in accordance with a phase pattern in which phase values corresponding to the plurality of pixels are two-dimensionally distributed, wherein the phase pattern is a phase pattern generated based on a predetermined basic phase pattern, wherein the basic phase pattern (31A-31J) includes a first region (32A-32J) in which the phase value continuously increases in a predetermined direction and a second region (33A-33J) in which the phase value continuously decreases in the predetermined direction and facing the first region (32A-32J) in the predetermined direction, and the basic phase pattern further includes a third region (34E-34J) in which the phase value is constant such that stripe-like illumination light in which gaps are formed at regular intervals on the stripes is generated.
A cassette apparatus for an infusion pump, the cassette apparatus comprising: a cassette for operatively connecting administration set tubing (24, 26) to the infusion pump, a press tab having an upwardly facing press surface and an undersurface; and a cassette interface on the infusion pump for removably receiving the cassette, the cassette interface including at least one fulcrum member; wherein the undersurface of the press tab engages the at least one fulcrum member when the cassette is received by the cassette interface; wherein the cassette is pivotable relative to the at least one fulcrum member by pressing the press surface of the press tab to assist in removing the cassette from the cassette interface. a cassette for operatively connecting administration set tubing (24, 26) to the infusion pump, a press tab having an upwardly facing press surface and an undersurface; and a cassette interface on the infusion pump for removably receiving the cassette, the cassette interface including at least one fulcrum member; wherein the undersurface of the press tab engages the at least one fulcrum member when the cassette is received by the cassette interface; wherein the cassette is pivotable relative to the at least one fulcrum member by pressing the press surface of the press tab to assist in removing the cassette from the cassette interface.
A trocar assembly (120, 420) comprising: a trocar housing (122, 422) including an inner surface defining a lumen; an annular seal (300, 500) positioned within the lumen of the trocar housing, the annular seal having an inner annular surface (302, 502) defining an inner opening (305, 505); a trocar (123, 423) disposed within the lumen of the trocar housing, extending through the inner opening of the annular seal, and movable through the lumen of the trocar and the inner opening of the annular seal, the trocar including an elongate body portion (125, 425) having a distal end and a trocar member (124, 424) extending distally from the distal end of the elongate body portion; and a seal retainer (350, 550) operably coupled to the trocar housing, the seal retainer positioned to retain the annular seal within the lumen of the trocar housing wherein the seal retainer includes a proximal lip (351a, 551a) and a distal lip (351b, 551b) and defines an inner annular region between the proximal lip and the distal lip, characterised in that the annular seal includes an outer surface having a proximal lip (301a, 501a) and a distal lip (301b, 501b); and the proximal lip and the distal lip of the outer surface of the annular seal extend radially outwardly from the outer surface of the annular seal. a trocar housing (122, 422) including an inner surface defining a lumen; an annular seal (300, 500) positioned within the lumen of the trocar housing, the annular seal having an inner annular surface (302, 502) defining an inner opening (305, 505); a trocar (123, 423) disposed within the lumen of the trocar housing, extending through the inner opening of the annular seal, and movable through the lumen of the trocar and the inner opening of the annular seal, the trocar including an elongate body portion (125, 425) having a distal end and a trocar member (124, 424) extending distally from the distal end of the elongate body portion; and a seal retainer (350, 550) operably coupled to the trocar housing, the seal retainer positioned to retain the annular seal within the lumen of the trocar housing wherein the seal retainer includes a proximal lip (351a, 551a) and a distal lip (351b, 551b) and defines an inner annular region between the proximal lip and the distal lip, characterised in that the annular seal includes an outer surface having a proximal lip (301a, 501a) and a distal lip (301b, 501b); and the proximal lip and the distal lip of the outer surface of the annular seal extend radially outwardly from the outer surface of the annular seal.
A method of manufacturing brushes, in particular toothbrushes, in which a) a carrier platelet (10; 20; 110) having bundle holes (14; 24; 114) for fiber bundles (16; 26; 116) and at least one passage hole or recess for a soft-elastic element (12; 22; 112) is manufactured in a two-component injection molding tool; b) the soft-elastic element (12; 22; 112) is manufactured by injecting a soft-elastic material in a first injection mold of the two-component injection molding tool through the passage hole or recess; c) in a following manufacturing step, the carrier platelet (10; 20; 110) with the at least one soft-elastic element (12; 22; 112) and with the bundle holes (14; 24; 114) for the fiber bundles (16; 26; 116) is introduced into an anchor-free tufting tool in which the fiber bundles (16; 26; 116) are inserted into the bundle holes (14; 24; 114) and are fastened to the carrier platelet (10; 20; 110) by d) fastening the fastening ends of the fiber bundles (16; 26; 116) emerging from the bundle holes (14; 24; 114) to the carrier platelet (10; 20; 110) by fusion; and e) in a subsequent manufacturing step, the carrier platelet (10; 20; 110) with the soft-elastic element (12; 22; 112) and with the fiber bundles (16; 26; 116) is introduced into an injection molding tool, into a second injection mold in which at least part of a brush body is integrally injection molded with the carrier platelet (10; 20; 110) or the carrier platelet (10; 20; 110) is insert molded with the brush body in sections. a) a carrier platelet (10; 20; 110) having bundle holes (14; 24; 114) for fiber bundles (16; 26; 116) and at least one passage hole or recess for a soft-elastic element (12; 22; 112) is manufactured in a two-component injection molding tool; b) the soft-elastic element (12; 22; 112) is manufactured by injecting a soft-elastic material in a first injection mold of the two-component injection molding tool through the passage hole or recess; c) in a following manufacturing step, the carrier platelet (10; 20; 110) with the at least one soft-elastic element (12; 22; 112) and with the bundle holes (14; 24; 114) for the fiber bundles (16; 26; 116) is introduced into an anchor-free tufting tool in which the fiber bundles (16; 26; 116) are inserted into the bundle holes (14; 24; 114) and are fastened to the carrier platelet (10; 20; 110) by d) fastening the fastening ends of the fiber bundles (16; 26; 116) emerging from the bundle holes (14; 24; 114) to the carrier platelet (10; 20; 110) by fusion; and e) in a subsequent manufacturing step, the carrier platelet (10; 20; 110) with the soft-elastic element (12; 22; 112) and with the fiber bundles (16; 26; 116) is introduced into an injection molding tool, into a second injection mold in which at least part of a brush body is integrally injection molded with the carrier platelet (10; 20; 110) or the carrier platelet (10; 20; 110) is insert molded with the brush body in sections.
An absorbent article for personal hygiene having a wearer-facing side, a garment-facing side, and a longitudinal axis, wherein the absorbent article has a length measured along the longitudinal axis, the article comprising: - a liquid permeable topsheet on the wearer-facing side; - a liquid impermeable backsheet on the garment-facing side; - an absorbent core between the topsheet and the backsheet; and - an acquisition layer between the topsheet and the absorbent core, characterized in that the acquisition layer comprises two, three or more discrete pieces (521, 522, 523) of an acquisition material, wherein the pieces of acquisition material are longitudinally-orientated stripes, wherein at least some or all the stripes have a length as measured in the longitudinal direction which is at least 25% of the length of the article. - a liquid permeable topsheet on the wearer-facing side; - a liquid impermeable backsheet on the garment-facing side; - an absorbent core between the topsheet and the backsheet; and - an acquisition layer between the topsheet and the absorbent core,
A bicycle wheel rim structure comprising: a rim including a first annular side portion, a second annular side portion and an annular bridge portion extending between the first and second annular side portions, the bridge portion having at least one opening; a cap including a base plate overlying an outer rim surface of the annular bridge portion, and a projection that extend from the base plate into the at least one opening; and a tape attached to the outer rim surface of the annular bridge portion and overlying the base plate of the cap, the tape being dimensioned to cover an interface between a peripheral edge of the base plate of the cap and the outer rim surface of the annular bridge portion, characterized in that the projection includes a plurality of protrusions extending from a lower surface of the base plate, the protrusions and the at least one opening in the annular bridge portion are dimensioned relative to each other such that the cap is retained in the at least one opening in the annular bridge portion by at least one of the protrusions applying a force against the annular bridge portion due to deformation of the at least one of the protrusions. a rim including a first annular side portion, a second annular side portion and an annular bridge portion extending between the first and second annular side portions, the bridge portion having at least one opening; a cap including a base plate overlying an outer rim surface of the annular bridge portion, and a projection that extend from the base plate into the at least one opening; and a tape attached to the outer rim surface of the annular bridge portion and overlying the base plate of the cap, the tape being dimensioned to cover an interface between a peripheral edge of the base plate of the cap and the outer rim surface of the annular bridge portion, characterized in that the projection includes a plurality of protrusions extending from a lower surface of the base plate, the protrusions and the at least one opening in the annular bridge portion are dimensioned relative to each other such that the cap is retained in the at least one opening in the annular bridge portion by at least one of the protrusions applying a force against the annular bridge portion due to deformation of the at least one of the protrusions.
A composition comprising an mRNA encoding a therapeutic protein encapsulated within a liposome for use in a method of treating a disease or disorder comprising administering to a subject in need of treatment the composition; wherein the composition is injected intradermally, intramuscularly, or subcutaneously or administered intrathecally, intraventricularly, or intravenously and expression of the protein encoded by the mRNA is detectable in the liver, kidney, heart, spleen, serum, brain, skeletal muscle, lymph nodes, skin, and/or cerebrospinal fluid, and the liposome comprises a cationic lipid of formula I-g: or a pharmaceutically acceptable salt thereof, wherein each of R L is optionally substituted C 8-10 alkyl and the liposome further comprises a non-cationic lipid, a cholesterol-based lipid and a PEG-modified lipid, wherein the molar ratio of cationic lipid to non-cationic lipid to cholesterol-based lipid to PEG-modified lipid is 30-50:25-35:20-30:1-15. the liposome comprises a cationic lipid of formula I-g: or a pharmaceutically acceptable salt thereof, wherein each of R L is optionally substituted C 8-10 alkyl and the liposome further comprises a non-cationic lipid, a cholesterol-based lipid and a PEG-modified lipid, wherein the molar ratio of cationic lipid to non-cationic lipid to cholesterol-based lipid to PEG-modified lipid is 30-50:25-35:20-30:1-15.
A method for ascertaining the temperature of a portion of a rope having a strength member formed mainly from synthetic fibers, the method characterized by steps of: a) forming the rope so that it includes at each of various distinct locations along the length of the rope and included within a centrally located creep tolerant rod dimensioned to fill out the centrally located space of the hollow braided rope at least one of several individual magnets; b) next, using the rope in a certain application; c) next, while using the rope in the certain application, measuring a physical signal associated with at least one of the magnets that is included within the rope so as to obtain a measurement associated with the signal; d) identifying a temperature and/or temperature range by comparing the obtained measurement to previously obtained data identifying various temperature measurements and/or ranges of temperature measurements for various specific measurements of the same type of signal as measured in step (c) above. a) forming the rope so that it includes at each of various distinct locations along the length of the rope and included within a centrally located creep tolerant rod dimensioned to fill out the centrally located space of the hollow braided rope at least one of several individual magnets; b) next, using the rope in a certain application; c) next, while using the rope in the certain application, measuring a physical signal associated with at least one of the magnets that is included within the rope so as to obtain a measurement associated with the signal; d) identifying a temperature and/or temperature range by comparing the obtained measurement to previously obtained data identifying various temperature measurements and/or ranges of temperature measurements for various specific measurements of the same type of signal as measured in step (c) above.
A vacuum adsorption system for a mother substrate to be packaged, which includes a vacuum adsorption platform, wherein the vacuum adsorption system further includes: a carrying platform, which is provided on the vacuum adsorption platform and edges thereof are sealed with edges of the vacuum adsorption platform, configured to carrying the mother substrate to be packaged and provided thereon with a plurality of adsorption units, the adsorption units being used for adsorbing, in cooperation with the vacuum adsorption platform, the mother substrate to be packaged so as to fix the mother substrate to be packaged; a detection unit, configured to detect positional relationships between the adsorption units on the carrying platform and packaging areas on the mother substrate to be packaged; and an adjustment unit, the vacuum adsorption system being characterized in that: said adjustment unit is configured to adjust the position of the carrying platform when the detection unit detects that the positions of the adsorption units on the carrying platform are overlapped with the packaging areas on the mother substrate to be packaged, so that positions of at least part of the adsorption units on the carrying platform are not overlapped with the packaging areas on the mother substrate to be packaged. a carrying platform, which is provided on the vacuum adsorption platform and edges thereof are sealed with edges of the vacuum adsorption platform, configured to carrying the mother substrate to be packaged and provided thereon with a plurality of adsorption units, the adsorption units being used for adsorbing, in cooperation with the vacuum adsorption platform, the mother substrate to be packaged so as to fix the mother substrate to be packaged; a detection unit, configured to detect positional relationships between the adsorption units on the carrying platform and packaging areas on the mother substrate to be packaged; and an adjustment unit, the vacuum adsorption system being characterized in that: said adjustment unit is configured to adjust the position of the carrying platform when the detection unit detects that the positions of the adsorption units on the carrying platform are overlapped with the packaging areas on the mother substrate to be packaged, so that positions of at least part of the adsorption units on the carrying platform are not overlapped with the packaging areas on the mother substrate to be packaged.
An apparatus for providing failsafe detection for a differential receiver that produces a bus activity indicator signal when receiving a differential data signal having an amplitude that transitions through a predetermined receiver threshold, said apparatus comprising: a window comparator having an input coupled to said differential receiver and operable to activate a failsafe signal when a low differential voltage transition indicative of a fault condition occurs on said differential receiver; a timer coupled to said window comparator and having an input to receive said bus activity indicator signal and said failsafe signal, said timer operable to commence a countdown period in response to each activation of said bus activity indicator signal and said failsafe signal, said timer being further operable to generate a timeout signal; and a failsafe indicator gate coupled to said timer and said window comparator to receive said timeout signal and said failsafe signal, and having an output to set a flag when said failsafe signal and the countdown time period expires. a window comparator having an input coupled to said differential receiver and operable to activate a failsafe signal when a low differential voltage transition indicative of a fault condition occurs on said differential receiver; a timer coupled to said window comparator and having an input to receive said bus activity indicator signal and said failsafe signal, said timer operable to commence a countdown period in response to each activation of said bus activity indicator signal and said failsafe signal, said timer being further operable to generate a timeout signal; and a failsafe indicator gate coupled to said timer and said window comparator to receive said timeout signal and said failsafe signal, and having an output to set a flag when said failsafe signal and the countdown time period expires.
A recombinant respiratory syncytial virus F polypeptide (RSV F) in which amino acids 100-150, numbered relative to SEQ ID NO: 1, are replaced with the amino acid sequence of: TPATNNRARQQQQRFLGFLLGVGSAIAS (SEQ ID NO:9). TPATNNRARQQQQRFLGFLLGVGSAIAS (SEQ ID NO:9).