Continuous multi-microencapsulation process of biologically active materials by means of in situ interfacial polymerization characterized in that the process is performed under continuous agitation and comprises the following steps: (a) in a first step it is emulsified a water phase into an oil phase; wherein a.1. a polymerization initiator exists in the water phase, a.2. an emulsifier exists in the oil or in the water phase, a.3. at least a biologically active ingredient exists in the oil and/or in the water phase; (b) in a second step, it is added to the emulsion a solution or dispersion in water that contains at least one hydrocolloid, this producing a phase inversion and the polymerization and cross-linking of the polymerizable hydrocolloid(s) onto the water in oil droplets; (c) in a third step, it is added a solution or dispersion in water that contains at least one protective colloid that begins to be deposited on the surface of the drops of water in oil, and to polymerize and cross-link with itself and the hydrocolloid; (d) in a fourth step, it is added to a solution or dispersion in water of a surfactant to allow a reduction of the size of the water in oil drops; (e) in a fifth step, during the process of reduction of size, the partially formed microcapsules are deaglomerated and reaglomerated, happening eventually an enclosure of drops inside bigger drops; (f) when enough time has passed in order that the oil and/or water in oil drops are covered by at least one hydrocolloid and at least one protective colloid, the temperature is increased in order to strengthen the wall of the formed microcapsules or multi-microcapsules suspended in water. (a) in a first step it is emulsified a water phase into an oil phase; wherein a.1. a polymerization initiator exists in the water phase, a.2. an emulsifier exists in the oil or in the water phase, a.3. at least a biologically active ingredient exists in the oil and/or in the water phase; a.1. a polymerization initiator exists in the water phase, a.2. an emulsifier exists in the oil or in the water phase, a.3. at least a biologically active ingredient exists in the oil and/or in the water phase; (b) in a second step, it is added to the emulsion a solution or dispersion in water that contains at least one hydrocolloid, this producing a phase inversion and the polymerization and cross-linking of the polymerizable hydrocolloid(s) onto the water in oil droplets; (c) in a third step, it is added a solution or dispersion in water that contains at least one protective colloid that begins to be deposited on the surface of the drops of water in oil, and to polymerize and cross-link with itself and the hydrocolloid; (d) in a fourth step, it is added to a solution or dispersion in water of a surfactant to allow a reduction of the size of the water in oil drops; (e) in a fifth step, during the process of reduction of size, the partially formed microcapsules are deaglomerated and reaglomerated, happening eventually an enclosure of drops inside bigger drops; (f) when enough time has passed in order that the oil and/or water in oil drops are covered by at least one hydrocolloid and at least one protective colloid, the temperature is increased in order to strengthen the wall of the formed microcapsules or multi-microcapsules suspended in water.