mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a) from 0.1% to 20% of an alkylene oxide derivative represented by the following formula: Z-{O 1 m - n H} a Wherein Z represents a residue of a compound having 3 to 9 hydroxyl groups with said hydroxyl groups removed, a is from 3 to 9, AO represents an oxyalkylene group of 3 to 4 carbon atoms, EO represents oxyethylene group, 1 and m represent average addition mol numbers of said oxyalkylene group of 3 to 4 carbon atoms and said oxyethylene group, respectively, and 1≦1≦50, l≦m≦50, the weight ratio (AO/EO) of AO to EO is from 1/5 to 5/1, AO and EO may be added in a random form or may be added in a block form, BO represents an oxyalkylene group with a number of carbon atoms of 4, and n is an average additional mol number and 0.5≦n≦5, in a cosmetic composition comprising b) from 0.001% to 10% of an N-acyl amino acid compound according to the formula wherein R is a hydrogen, alkyl (substituted or unsubstituted, branched or straight chain), or a combination of alkyl and aromatic groups; and R 1 is C 1 to C 30, saturated or unsaturated, straight or branched, substituted or unsubstituted alkyls; substituted or unsubstituted aromatic groups; or mixtures thereof; and c) dermatologically acceptable carrier, for use in mitigating irritation of the skin upon use of said composition. a) from 0.1% to 20% of an alkylene oxide derivative represented by the following formula: Z-{O 1 m - n H} a Wherein Z represents a residue of a compound having 3 to 9 hydroxyl groups with said hydroxyl groups removed, a is from 3 to 9, AO represents an oxyalkylene group of 3 to 4 carbon atoms, EO represents oxyethylene group, 1 and m represent average addition mol numbers of said oxyalkylene group of 3 to 4 carbon atoms and said oxyethylene group, respectively, and 1≦1≦50, l≦m≦50, the weight ratio (AO/EO) of AO to EO is from 1/5 to 5/1, AO and EO may be added in a random form or may be added in a block form, BO represents an oxyalkylene group with a number of carbon atoms of 4, and n is an average additional mol number and 0.5≦n≦5, in a cosmetic composition comprising b) from 0.001% to 10% of an N-acyl amino acid compound according to the formula wherein R is a hydrogen, alkyl (substituted or unsubstituted, branched or straight chain), or a combination of alkyl and aromatic groups; and R 1 is C 1 to C 30, saturated or unsaturated, straight or branched, substituted or unsubstituted alkyls; substituted or unsubstituted aromatic groups; or mixtures thereof; and c) dermatologically acceptable carrier, for use in mitigating irritation of the skin upon use of said composition.
A drive device for an aircraft, at least comprising a battery for storing electrical energy, an electric motor for driving a propeller, a conductive means for transferring electrical energy from the battery to the electric motor, and a first control means for controlling the electric motor, characterised in that - the battery is a lithium-air battery, - the electric motor is a high temperature superconducting motor, - at least one reservoir for a coolant and a cooling system connected to the reservoir are present for cooling the high temperature superconducting motor, wherein the cooling system comprises a second control means for controlling the cooling system, - a first means for variable arrangement of the lithium-air battery and/or a second means for variable arrangement of the reservoir in the aircraft is/are present, and - a third control means for controlling the first means and/or second means is present, wherein the first means and/or the second means is/are controlled in such a manner that the lithium-air battery and/or the reservoir are arranged in the aircraft in such a manner that an increase in the mass of the lithium-air battery, which occurs during operation of the drive device, and a decrease in the mass of the liquid nitrogen in the reservoir, which occurs during operation of the drive device, do not change the position of the centre of gravity of the aircraft. - the battery is a lithium-air battery, - the electric motor is a high temperature superconducting motor, - at least one reservoir for a coolant and a cooling system connected to the reservoir are present for cooling the high temperature superconducting motor, wherein the cooling system comprises a second control means for controlling the cooling system, - a first means for variable arrangement of the lithium-air battery and/or a second means for variable arrangement of the reservoir in the aircraft is/are present, and - a third control means for controlling the first means and/or second means is present, wherein the first means and/or the second means is/are controlled in such a manner that the lithium-air battery and/or the reservoir are arranged in the aircraft in such a manner that an increase in the mass of the lithium-air battery, which occurs during operation of the drive device, and a decrease in the mass of the liquid nitrogen in the reservoir, which occurs during operation of the drive device, do not change the position of the centre of gravity of the aircraft.
A pharmaceutical composition comprising at least one active pharmaceutical ingredient having potential for abuse or a pharmaceutically acceptable salt thereof, 20% to 35% by weight of at least one low molecular weight hydrophilic polymer having an average molecular weight of no more than 200,000 Daltons, 1% to 15% by weight of at least one high molecular weight hydrophilic polymer having an average molecular weight of at least 400,000 Daltons, and 50% to 70% by weight of an effervescent system, wherein when the pharmaceutical composition is milled for 6 minutes to form particles, more than 30% of the particles have an average diameter of greater than 250 microns.
A neural network circuit for applying a threshold to a weighted sum of input signals, the neural network circuit comprising - at least two arrays (30, 31) of transistors with programmable threshold voltage, each transistor storing a synaptic weight as a threshold voltage and having a control electrode for receiving an activation input signal, each transistor of the at least two arrays providing an output current for either a positive weighted current component in an array of a set of first arrays or a negative weighted current component in an array of a set of second arrays, characterized in that the neural network circuit further comprises - for each array of transistors, a reference network (33, 32) associated therewith, for providing a reference signal to be combined with the positive or negative weight current components of the transistors of the associated array, the reference signal having opposite sign compared to the weight current components of the associated array, thereby applying the threshold to the weighted sums of the currents, - at least one bit line for receiving the combined positive and negative current components, each combined with their associated reference signals, or at least two bitlines, of which at least one for positive current components combined with their associated reference signal and at least one for negative components combined with their associated reference signal. - at least two arrays (30, 31) of transistors with programmable threshold voltage, each transistor storing a synaptic weight as a threshold voltage and having a control electrode for receiving an activation input signal, each transistor of the at least two arrays providing an output current for either a positive weighted current component in an array of a set of first arrays or a negative weighted current component in an array of a set of second arrays, - for each array of transistors, a reference network (33, 32) associated therewith, for providing a reference signal to be combined with the positive or negative weight current components of the transistors of the associated array, the reference signal having opposite sign compared to the weight current components of the associated array, thereby applying the threshold to the weighted sums of the currents, - at least one bit line for receiving the combined positive and negative current components, each combined with their associated reference signals, or at least two bitlines, of which at least one for positive current components combined with their associated reference signal and at least one for negative components combined with their associated reference signal.
A cutter blade to be attached to a robot via a biasing mechanism, the cutter blade comprising: a profiling surface to be pressed against a surface portion of a workpiece by the biasing mechanism, and a cutting edge portion including a blade edge positioned on a ridgeline formed by the profiling surface and a rake surface, the cutting edge portion including a clearance portion located behind, relative to an advancement direction, the profiling surface, to be vibrated in use by a transducer and characterized by having a wedge angle (β) of 30° to 80°, the profiling surface and the cutting edge portion being integrated. a profiling surface to be pressed against a surface portion of a workpiece by the biasing mechanism, and a cutting edge portion including a blade edge positioned on a ridgeline formed by the profiling surface and a rake surface, the cutting edge portion including a clearance portion located behind, relative to an advancement direction, the profiling surface, to be vibrated in use by a transducer and characterized by having a wedge angle (β) of 30° to 80°, the profiling surface and the cutting edge portion being integrated.
An egress seal fitting (200; 300) for a bulkhead penetration (208; 308), comprising: a housing (202; 302; 400), wherein the housing (202; 302; 400) comprises an annular cylindrical structure extending between a flanged portion and a base portion (216; 402); a driver (204; 304) configured to couple to the housing (202; 302; 400), wherein the driver (204; 304) comprises an annular cylindrical drive portion and a head, wherein the driver (204; 304) is configured to_define a driver cavity (218; 318) within the housing (202; 302; 400); and a seal member (228; 328) configured to be disposed within the driver cavity (218; 318) of the housing (202; 302; 400), wherein the driver (204; 304) is configured to pass a penetrating member (210; 310) through the housing (202; 302; 400) and apply pressure to the seal member (228; 328), characterised in that the housing (202; 302; 400) is separated into a first housing half (202'; 302') and a second housing half (202"), wherein the driver (204; 304) is divided into a first driver half (204'; 304') and a second driver half (204"). a housing (202; 302; 400), wherein the housing (202; 302; 400) comprises an annular cylindrical structure extending between a flanged portion and a base portion (216; 402); a driver (204; 304) configured to couple to the housing (202; 302; 400), wherein the driver (204; 304) comprises an annular cylindrical drive portion and a head, wherein the driver (204; 304) is configured to_define a driver cavity (218; 318) within the housing (202; 302; 400); and a seal member (228; 328) configured to be disposed within the driver cavity (218; 318) of the housing (202; 302; 400), wherein the driver (204; 304) is configured to pass a penetrating member (210; 310) through the housing (202; 302; 400) and apply pressure to the seal member (228; 328), characterised in that the housing (202; 302; 400) is separated into a first housing half (202'; 302') and a second housing half (202"), wherein the driver (204; 304) is divided into a first driver half (204'; 304') and a second driver half (204").
Lighting device comprising at least one semiconductor lighting means and a housing made of plastic, in which the at least one semiconductor lighting means is accommodated, wherein the housing comprises a housing lower part and a translucent housing upper part, which in a connecting region protrudes at least partially into the housing lower part, wherein the housing upper part and the housing lower part are screwed to one another, wherein provided on the housing upper part and on the housing lower part are latching means which engage in one another in one or more predefined rotary positions and prevent unscrewing of the housing upper part from the housing lower part, wherein one or more inwardly facing threaded sections are formed in an upper region of the housing lower part, wherein at least one inwardly facing latching protrusion is formed as a latching means in an area of threaded sections or below the area of the threaded sections in the housing lower part, characterized in that - at least one downwardly open latching cutout is formed as a latching means on the lower edge of the housing upper part, wherein a downwardly protruding spring tongue is formed at one side of the at least one latching cutout, - the latching protrusion is located in the latching cutout in the latched rotary position, and - the spring tongue bears with its free end against one side of the latching protrusion in the latched rotary position. - at least one downwardly open latching cutout is formed as a latching means on the lower edge of the housing upper part, wherein a downwardly protruding spring tongue is formed at one side of the at least one latching cutout, - the latching protrusion is located in the latching cutout in the latched rotary position, and - the spring tongue bears with its free end against one side of the latching protrusion in the latched rotary position.
A torsion spring driven injection device having a dial-down mechanism for dialling down a selected dose size, comprising a torsion spring which is strained when setting a dose by rotating a proximally located dose setting button relatively to a housing in a first direction and unstrained when rotating the same dose setting button in a second direction opposite the first direction, the dial-down mechanism further comprising: a fixation element coupled to the housing and having a toothing, a ratchet element provided in the proximal end of the injection device and having at least one ratchet arm engaging the fixation element and which ratchet element is operational coupled to the dose setting button, and wherein the at least one ratchet arm engages the toothing of the fixation element and is shaped such that the ratchet element is prevented from rotating relatively to fixation element in the second direction when the ratchet arm engages the toothing of the fixation element, and wherein the dose setting button directly engages the at least one ratchet arm when the dose setting button is rotated in the second direction to thereby release the at least one ratchet arm from the toothing of the fixation element and allow the ratchet element to rotate relatively to the fixation element in the second direction under influence of the torsion spring, characterized in that the fixation element is permanently coupled to the housing. a fixation element coupled to the housing and having a toothing, a ratchet element provided in the proximal end of the injection device and having at least one ratchet arm engaging the fixation element and which ratchet element is operational coupled to the dose setting button, and wherein the at least one ratchet arm engages the toothing of the fixation element and is shaped such that the ratchet element is prevented from rotating relatively to fixation element in the second direction when the ratchet arm engages the toothing of the fixation element, and wherein the dose setting button directly engages the at least one ratchet arm when the dose setting button is rotated in the second direction to thereby release the at least one ratchet arm from the toothing of the fixation element and allow the ratchet element to rotate relatively to the fixation element in the second direction under influence of the torsion spring, characterized in that the fixation element is permanently coupled to the housing.
A method for obtaining purified recombinant Adeno-Associated Virus (rAAV) particles, comprising the steps of: a) performing a depth filtration of a starting material previously obtained from cells producing rAAV particles, said starting material comprising a cell lysate and/or a culture supernatant, whereby a rAAV-containing clarified composition is provided; b) adjusting the pH of the rAAV-containing clarified composition at a basic pH so as to ensure optimal retention of the rAAV particles on the chromatographic support used at step c); c) submitting the rAAV-containing clarified composition of step b) to a first step of anion-exchange chromatography on a chromatographic support, wherein elution is performed by using a linear salt gradient and wherein the rAAV-containing fraction is collected, whereby a first rAAV-enriched composition is provided; d) submitting the first rAAV-enriched composition at least once to a second step of anion-exchange chromatography on a chromatographic support wherein elution is performed by using a linear salt gradient and wherein the rAAV-containing fraction is collected, whereby a second rAAV-enriched composition is provided; e) submitting the second rAAV-enriched composition to a step of tangential flow filtration, whereby purified recombinant Adeno-Associated Virus (rAAV) particles are provided, wherein said method comprises neither an apatite chromatography nor a cation-exchange chromatography step, and wherein said rAAV particles belong to an AAV capsid serotype selected from the group consisting of AAV5, AAV8, AAV9 and AAV2. a) performing a depth filtration of a starting material previously obtained from cells producing rAAV particles, said starting material comprising a cell lysate and/or a culture supernatant, whereby a rAAV-containing clarified composition is provided; b) adjusting the pH of the rAAV-containing clarified composition at a basic pH so as to ensure optimal retention of the rAAV particles on the chromatographic support used at step c); c) submitting the rAAV-containing clarified composition of step b) to a first step of anion-exchange chromatography on a chromatographic support, wherein elution is performed by using a linear salt gradient and wherein the rAAV-containing fraction is collected, whereby a first rAAV-enriched composition is provided; d) submitting the first rAAV-enriched composition at least once to a second step of anion-exchange chromatography on a chromatographic support wherein elution is performed by using a linear salt gradient and wherein the rAAV-containing fraction is collected, whereby a second rAAV-enriched composition is provided; e) submitting the second rAAV-enriched composition to a step of tangential flow filtration, whereby purified recombinant Adeno-Associated Virus (rAAV) particles are provided, wherein said method comprises neither an apatite chromatography nor a cation-exchange chromatography step, and wherein said rAAV particles belong to an AAV capsid serotype selected from the group consisting of AAV5, AAV8, AAV9 and AAV2.
An antibody or a fragment thereof which binds a partial CAPRIN-1 polypeptide consisting of the amino acid sequence Ala Glu Gln Lys Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu (SEQ ID NO: 5).
A transport refrigeration system comprising: a refrigeration unit; a diesel engine powering the refrigeration unit, the diesel engine having an exhaust system for discharging engine exhaust from the diesel engine; an exhaust treatment unit disposed in the diesel engine exhaust system, the exhaust treatment unit including a diesel oxidation catalyst and a diesel particulate filter; an air control valve configured to control a quantity of air provided to the diesel engine from an air supply fluidly coupled to the diesel engine; and characterised by a controller operably coupled to the air control valve, wherein after initiating regeneration of the diesel particulate filter, the controller is configured to operate the system in one of a primary regeneration mode and a secondary regeneration mode in response to a condition monitored within the exhaust treatment unit; wherein the condition is a rate of temperature change of the exhaust gas and the secondary regeneration mode is used if the rate of temperature change satisfies a pre-determined condition. a diesel engine powering the refrigeration unit, the diesel engine having an exhaust system for discharging engine exhaust from the diesel engine; an exhaust treatment unit disposed in the diesel engine exhaust system, the exhaust treatment unit including a diesel oxidation catalyst and a diesel particulate filter; an air control valve configured to control a quantity of air provided to the diesel engine from an air supply fluidly coupled to the diesel engine; and characterised by a controller operably coupled to the air control valve, wherein after initiating regeneration of the diesel particulate filter, the controller is configured to operate the system in one of a primary regeneration mode and a secondary regeneration mode in response to a condition monitored within the exhaust treatment unit; wherein the condition is a rate of temperature change of the exhaust gas and the secondary regeneration mode is used if the rate of temperature change satisfies a pre-determined condition.
Fine particle dispersion of infrared-shielding material, in which fine particles of an infrared-shielding material are dispersed in a medium, characterized in that the fine particles of the infrared-shielding material comprise tungsten oxide composite fine particles expressed by a general formula MxWyOz (where M is one or more elements selected from the group consisting of Cs, Rb, Tl, In, Ba, Li, Ca, Sr, and Fe, W is tungsten, O is oxygen, satisfying 0.2 ≤ x/y ≤ 0.5, and 2.2 ≤ z/y ≤ 3.0) and having hexagonal crystal structure, and wherein a diameter of the fine particles of the infrared-shielding material is not less than 1 nm and not more than 800 nm.
An apparatus for displaying an image, comprising: a display unit to display a perceived three-dimensional stereoscopic image; a memory unit to store a first image of an object from a first viewpoint, a second image of an object from a second viewpoint and a third image of an object from a third viewpoint; and a controller characterized in that the controller is configured to determine that the display unit is a first display condition or that the display unit is a second display condition, wherein when the controller determines that the display unit is the first condition, the controller controls the perceived 3D stereoscopic image to be displayed via the display unit by using the first image and the second image, and when the controller determines that the display unit is the second condition, the controller controls the perceived 3D stereoscopic image to be displayed via the display unit by using the first image and the third image; characterized by a first camera to capture the first image of the object from the first viewpoint; a second camera to capture the second image of the object from the second viewpoint, and to capture the third image of the object from the third viewpoint, and a multi-step retractable overlapping pipe member (ra) to slide the second camera between the second view point and the third view point. a display unit to display a perceived three-dimensional stereoscopic image; a memory unit to store a first image of an object from a first viewpoint, a second image of an object from a second viewpoint and a third image of an object from a third viewpoint; and a controller characterized in that the controller is configured to determine that the display unit is a first display condition or that the display unit is a second display condition, wherein when the controller determines that the display unit is the first condition, the controller controls the perceived 3D stereoscopic image to be displayed via the display unit by using the first image and the second image, and when the controller determines that the display unit is the second condition, the controller controls the perceived 3D stereoscopic image to be displayed via the display unit by using the first image and the third image;