mhurhangee/ep-ind-claims huggingface dataset:
Pyridazine compounds of formula I, wherein A is a furan, or thiophene, or pyrrole radical of formulae A1, or A2, wherein # denotes the binding site to the remainder of formula I; n is 0, 1, 2, or 3; R A is independently of the integer of n selected from hydrogen, halogen, CN, NO 2, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl and C 2 -C 10 -alkynyl, wherein the 3 last mentioned radicals may be unsubstituted, may be partially or fully halogenated, and wherein each R A is further independently of each other selected from OR a; Z is O, S or NR N; R N is selected from C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy-C 2 -C 4 -alkyl; R t, R u, and R w are independently of each other selected from hydrogen, fluorine, chlorine, bromine, methyl, difluoromethyl, trifluoromethyl, methoxy and difluoromethoxy; R 1 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 3 -alkylen-O-C 1 -C 3 -alkyl; R a are independently of each other selected from hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkylmethyl, and C 3 -C 6 -halocycloalkyl; or their agriculturally or veterinally acceptable salts, N-oxides, enantiomers or diastereomers thereof. A is a furan, or thiophene, or pyrrole radical of formulae A1, or A2, wherein # denotes the binding site to the remainder of formula I; n is 0, 1, 2, or 3; R A is independently of the integer of n selected from hydrogen, halogen, CN, NO 2, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl and C 2 -C 10 -alkynyl, wherein the 3 last mentioned radicals may be unsubstituted, may be partially or fully halogenated, and wherein each R A is further independently of each other selected from OR a; Z is O, S or NR N; R N is selected from C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl, and C 1 -C 4 -alkoxy-C 2 -C 4 -alkyl; R t, R u, and R w are independently of each other selected from hydrogen, fluorine, chlorine, bromine, methyl, difluoromethyl, trifluoromethyl, methoxy and difluoromethoxy; R 1 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 3 -alkylen-O-C 1 -C 3 -alkyl; R a are independently of each other selected from hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkylmethyl, and C 3 -C 6 -halocycloalkyl; or their agriculturally or veterinally acceptable salts, N-oxides, enantiomers or diastereomers thereof.
An isolated antibody that binds ILT5 or an ILT5-binding fragment of the antibody that comprises the regions described in a) or b) below: a) a heavy chain complementarity determining region 1 (VH CDR1) comprising the amino acid sequence of SEQ ID NO: 4; a heavy chain complementarity determining region 2 (VH CDR2) comprising the amino acid sequence of SEQ ID NO: 5; a heavy chain complementarity determining region 3 (VH CDR3) comprising the amino acid sequence of SEQ ID NO: 6; a light chain complementarity determining region 1 (VL CDR1) comprising the amino acid sequence of SEQ ID NO: 7; a light chain complementarity determining region 2 (VL CDR2) comprising the amino acid sequence of SEQ ID NO: 8; and a light chain complementarity determining region 3 (VL CDR3) comprising the amino acid sequence of SEQ ID NO: 9; b) a heavy chain complementarity determining region 1 (VH CDR1) consisting of the amino acid sequence of SEQ ID NO: 4; a heavy chain complementarity determining region 2 (VH CDR2) consisting of the amino acid sequence of SEQ ID NO: 5; a heavy chain complementarity determining region 3 (VH CDR3) consisting of the amino acid sequence of SEQ ID NO: 6; a light chain complementarity determining region 1 (VL CDR1) consisting of the amino acid sequence of SEQ ID NO: 7; a light chain complementarity determining region 2 (VL CDR2) consisting of the amino acid sequence of SEQ ID NO: 8; and a light chain complementarity determining region 3 (VL CDR3) consisting of the amino acid sequence of SEQ ID NO: 9, wherein the ILT-5 is human ILT-5. a) a heavy chain complementarity determining region 1 (VH CDR1) comprising the amino acid sequence of SEQ ID NO: 4; a heavy chain complementarity determining region 2 (VH CDR2) comprising the amino acid sequence of SEQ ID NO: 5; a heavy chain complementarity determining region 3 (VH CDR3) comprising the amino acid sequence of SEQ ID NO: 6; a light chain complementarity determining region 1 (VL CDR1) comprising the amino acid sequence of SEQ ID NO: 7; a light chain complementarity determining region 2 (VL CDR2) comprising the amino acid sequence of SEQ ID NO: 8; and a light chain complementarity determining region 3 (VL CDR3) comprising the amino acid sequence of SEQ ID NO: 9; b) a heavy chain complementarity determining region 1 (VH CDR1) consisting of the amino acid sequence of SEQ ID NO: 4; a heavy chain complementarity determining region 2 (VH CDR2) consisting of the amino acid sequence of SEQ ID NO: 5; a heavy chain complementarity determining region 3 (VH CDR3) consisting of the amino acid sequence of SEQ ID NO: 6; a light chain complementarity determining region 1 (VL CDR1) consisting of the amino acid sequence of SEQ ID NO: 7; a light chain complementarity determining region 2 (VL CDR2) consisting of the amino acid sequence of SEQ ID NO: 8; and a light chain complementarity determining region 3 (VL CDR3) consisting of the amino acid sequence of SEQ ID NO: 9,
Sheet handling apparatus apt to pick up sheets from a pack of sheets to be delivered to a cutting centre and for removing a separating foil between said sheets, comprising lifting and removing means for a top sheet (L 1) equipped with upper gripping heads, air flow generating means (8, 9, 10) generating an air flow above said pack of sheets, characterized by the fact that it further comprises control means of said lifting means, defining a stasis height and stasis time whereby said top sheet (L 1) is maintained at a height lower than about 70 mm above said pack of sheets, said air flow generating means (8, 9, 10) being operative at least during said stasis time, wherein said air flow generating means comprise a suction machine equipped with a convergent duct provided with a slot-shaped mouthpiece arranged close to one of smaller sides of said pack of sheets. lifting and removing means for a top sheet (L 1) equipped with upper gripping heads, air flow generating means (8, 9, 10) generating an air flow above said pack of sheets,
An apparatus for determining whether a ventricular pacing stimulus is capturing a paced ventricle, comprising: means for delivering a ventricular pacing stimulus; sensing means for sensing a signal in response to the ventricular pacing stimulus; processing means for determining whether a positive deflection of the signal precedes a negative deflection of the signal; and processing means for determining whether the ventricular pacing stimulus is capturing the paced ventricle in response to determining whether the positive deflection precedes the negative deflection; processing means for determining from the signal a maximum amplitude, a maximum time associated with the maximum amplitude, a minimum amplitude, and a minimum time associated with the minimum amplitude; and characterised by processing means for determining a numerator that is equal to an absolute value of the maximum amplitude minus a baseline, a denominator that is equal to an absolute value of the baseline minus the minimum amplitude, and a ratio that is the numerator divided by the denominator; processing means for determining whether the ratio is greater than a lower limit and whether the ratio is less than an upper limit; and processing means for determining whether the ventricular pacing stimulus is effectively capturing the paced ventricle in response to determining whether the ratio is greater than the lower limit and whether the ratio is less than the upper limit. means for delivering a ventricular pacing stimulus; sensing means for sensing a signal in response to the ventricular pacing stimulus; processing means for determining whether a positive deflection of the signal precedes a negative deflection of the signal; and processing means for determining whether the ventricular pacing stimulus is capturing the paced ventricle in response to determining whether the positive deflection precedes the negative deflection; processing means for determining from the signal a maximum amplitude, a maximum time associated with the maximum amplitude, a minimum amplitude, and a minimum time associated with the minimum amplitude; and characterised by processing means for determining a numerator that is equal to an absolute value of the maximum amplitude minus a baseline, a denominator that is equal to an absolute value of the baseline minus the minimum amplitude, and a ratio that is the numerator divided by the denominator; processing means for determining whether the ratio is greater than a lower limit and whether the ratio is less than an upper limit; and processing means for determining whether the ventricular pacing stimulus is effectively capturing the paced ventricle in response to determining whether the ratio is greater than the lower limit and whether the ratio is less than the upper limit.
A surgical stapler, comprising: a support jaw comprising a cartridge, the cartridge having an elongated body configured to removably house a plurality of B-form staples (150, 152, 154, 156), an anvil movably coupled to the support jaw between a clamped configuration wherein the anvil and the support jaw are configured to clamp tissue positioned therebetween, and a closed configuration wherein a tissue clamping interface in the anvil abuts a tissue clamping interface in the cartridge; wherein at least one of the plurality of B-form staples (150, 152, 154, 156) having a base length and a leg length, the cartridge further comprising a first slot shaped to receive a translating cutting mechanism, a second slot shaped to house at least a first one of the plurality of staples, and a third slot shaped to house at least a second one of the plurality of staples (150, 152, 154, 156) at an angle oblique to the first one of the plurality of staples (150, 152, 154, 156); the anvil and the support jaw comprising the cartridge are shaped to fit within a cannula when in the closed configuration; and an expandable cutting mechanism having a first member, the first member having a cutting portion, the cutting mechanism configured to move between a collapsed configuration wherein: the cutting mechanism is shaped to fit within the cannula and an expanded configuration wherein the cutting mechanism does not fit within the cannula and the first member is movable both longitudinally and transversely relative to the support jaw or cartridge. a support jaw comprising a cartridge, the cartridge having an elongated body configured to removably house a plurality of B-form staples (150, 152, 154, 156), an anvil movably coupled to the support jaw between a clamped configuration wherein the anvil and the support jaw are configured to clamp tissue positioned therebetween, and a closed configuration wherein a tissue clamping interface in the anvil abuts a tissue clamping interface in the cartridge; wherein at least one of the plurality of B-form staples (150, 152, 154, 156) having a base length and a leg length, the cartridge further comprising a first slot shaped to receive a translating cutting mechanism, a second slot shaped to house at least a first one of the plurality of staples, and a third slot shaped to house at least a second one of the plurality of staples (150, 152, 154, 156) at an angle oblique to the first one of the plurality of staples (150, 152, 154, 156); the anvil and the support jaw comprising the cartridge are shaped to fit within a cannula when in the closed configuration; and an expandable cutting mechanism having a first member, the first member having a cutting portion, the cutting mechanism configured to move between a collapsed configuration wherein: the cutting mechanism is shaped to fit within the cannula and an expanded configuration wherein the cutting mechanism does not fit within the cannula and the first member is movable both longitudinally and transversely relative to the support jaw or cartridge.
A device for stimulating one or more sensory fibers of at least one nerve, comprising an earpiece (10,210) comprising a housing (1,201) molded substantially to fit within the external ear canal of a subject; and a vibratory motor (2,202); characterised in that: wherein the vibratory motor (2,202) is embedded within the earpiece housing (1,201) or is coupled to the earpiece housing (1,201) to transmit vibrational energy to the outer wall of the housing; wherein the housing is further molded to contact the concha of a subject's ear and molded such that the device is capable of stimulating one or more sensory fibers of at least one nerve selected from the group consisting of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2 and spinal nerve C3; wherein the device further comprises a vibrating rod having a substantially flat plate and an elongated arm, wherein the plate is in contact with the vibratory motor (2,202) and the elongated arm extends away from the vibratory motor (2,202). wherein the vibratory motor (2,202) is embedded within the earpiece housing (1,201) or is coupled to the earpiece housing (1,201) to transmit vibrational energy to the outer wall of the housing; wherein the housing is further molded to contact the concha of a subject's ear and molded such that the device is capable of stimulating one or more sensory fibers of at least one nerve selected from the group consisting of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2 and spinal nerve C3; wherein the device further comprises a vibrating rod having a substantially flat plate and an elongated arm, wherein the plate is in contact with the vibratory motor (2,202) and the elongated arm extends away from the vibratory motor (2,202).
A fuel tank system (10, 110, 610) comprising: a fuel tank (12, 612); and an evaporative emissions control system (20, 120, 620) configured to recapture and recycle emitted fuel vapor, the evaporative emissions control system comprising: a purge canister (32, 632) adapted to collect fuel vapor emitted by the fuel tank (12, 612) a control module (30, 630); a manifold assembly (24, 624) having a first tank side solenoid (50, 650), a mechanical shut off valve and a canister side second solenoid (52, 652), wherein the canister side second solenoid (52, 652) is arranged between the fuel tank and the purge canister, a first pick up tube (40, 640) disposed in the fuel tank and fluidly connected to the manifold assembly; and a second pick up tube (42, 642) disposed in the fuel tank and fluidly connected to the manifold assembly (24, 624); wherein the control module (30, 630) is configured to regulate operation of the first (24, 624) and second (52, 652) solenoids to selectively open and close pathways in the manifold assembly (24, 624) to provide over-pressure and vacuum relief for the fuel tank (12, 612) and the manifold assembly is configured to control a flow of fuel vapor between the fuel tank (12, 612) and the purge canister (32, 632), the mechanical shut off valve configured to close fuel vapor communication from the fuel tank and out of the manifold assembly in the event of a roll-over or vehicle crash event. a fuel tank (12, 612); and an evaporative emissions control system (20, 120, 620) configured to recapture and recycle emitted fuel vapor, the evaporative emissions control system comprising: a purge canister (32, 632) adapted to collect fuel vapor emitted by the fuel tank (12, 612) a control module (30, 630); a manifold assembly (24, 624) having a first tank side solenoid (50, 650), a mechanical shut off valve and a canister side second solenoid (52, 652), wherein the canister side second solenoid (52, 652) is arranged between the fuel tank and the purge canister, a first pick up tube (40, 640) disposed in the fuel tank and fluidly connected to the manifold assembly; and a second pick up tube (42, 642) disposed in the fuel tank and fluidly connected to the manifold assembly (24, 624); a purge canister (32, 632) adapted to collect fuel vapor emitted by the fuel tank (12, 612) a control module (30, 630); a manifold assembly (24, 624) having a first tank side solenoid (50, 650), a mechanical shut off valve and a canister side second solenoid (52, 652), wherein the canister side second solenoid (52, 652) is arranged between the fuel tank and the purge canister, a first pick up tube (40, 640) disposed in the fuel tank and fluidly connected to the manifold assembly; and a second pick up tube (42, 642) disposed in the fuel tank and fluidly connected to the manifold assembly (24, 624);
A compound of formula I in free or salt form, wherein R 1 is -CO-NR x R y, where R x and R y together with the nitrogen to which they are attached form a substituted or unsubstituted 5- to 12-membered N-heterocyclic ring optionally including one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur wherein the optional substituents are selected from hydroxy, -SO 2 -CH 3 or aminocarbonyl; R 2 is C 1 -C 3 -alkyl; Y is carbon or nitrogen; and R 3 and R 4 are each independently hydrogen, halo, hydroxy, cyano, amino, carboxy, C 1 -C 8 -alkylsulfanyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, -SO 2 NH 2, C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, amino-C 1 -C 8 -alkyl, amino-C 1 -C 8 -alkoxy, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, di(C 1 -C 8 -alkyl)amino-C 1 -C 8 -alkyl, di(C 1 -C 8 -alkyl)amino-C 1 -C 8 -alkoxy, C 1 -C 8 -acylamino, aminocarbonyl, C 1 -C 8 -alkoxycarbonyl, carboxy-C 1 -C 8 -alkyl, carboxy-C 1 -C 8 -alkoxy, a C 3 -C 15 -carbocycle, a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, C 1 -C 8 -alkylamino or di(C 1 -C 8 -alkyl)amino each being optionally substituted by amino, hydroxy, di(C 1 -C 8 -alkyl)amino or a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, or C 1 -C 8 -alkoxy optionally substituted by a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur. R 1 is -CO-NR x R y, where R x and R y together with the nitrogen to which they are attached form a substituted or unsubstituted 5- to 12-membered N-heterocyclic ring optionally including one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur wherein the optional substituents are selected from hydroxy, -SO 2 -CH 3 or aminocarbonyl; R 2 is C 1 -C 3 -alkyl; Y is carbon or nitrogen; and R 3 and R 4 are each independently hydrogen, halo, hydroxy, cyano, amino, carboxy, C 1 -C 8 -alkylsulfanyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, -SO 2 NH 2, C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, amino-C 1 -C 8 -alkyl, amino-C 1 -C 8 -alkoxy, C 1 -C 8 -alkylaminocarbonyl, di(C 1 -C 8 -alkyl)aminocarbonyl, di(C 1 -C 8 -alkyl)amino-C 1 -C 8 -alkyl, di(C 1 -C 8 -alkyl)amino-C 1 -C 8 -alkoxy, C 1 -C 8 -acylamino, aminocarbonyl, C 1 -C 8 -alkoxycarbonyl, carboxy-C 1 -C 8 -alkyl, carboxy-C 1 -C 8 -alkoxy, a C 3 -C 15 -carbocycle, a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, C 1 -C 8 -alkylamino or di(C 1 -C 8 -alkyl)amino each being optionally substituted by amino, hydroxy, di(C 1 -C 8 -alkyl)amino or a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur, or C 1 -C 8 -alkoxy optionally substituted by a 5- or 6-membered heterocyclic ring having one or more ring hetero atoms selected from the group consisting of oxygen, nitrogen and sulphur.
A method of packaging a ceramic substrate (1, 14) for mounting at least one type of device selected from the group consisting of an LED, a semiconductor device, and a solar cell device, the method comprising steps of: providing a ceramic substrate (1, 14) comprising a through-hole for screw-fastening and a recessed portion for screw-fastening or for position registration provided on at least one edge surface thereof, the through-hole having a diameter of 1mm to 5mm, the recessed portion having a width of 1 mm to 5 mm and a depth of 1 mm to 5 mm, where the ceramic substrate (1, 14) being a silicon nitride substrate having a length (L1, L2) of one edge of 10 mm to 200 mm, a plate thickness of 0.2 mm to 1mm, characterised by a heat conductivity of 60 W/m·K or more, and a 3-point bending strength of 600 MPa or more at ambient temperature, and screw-fastening the ceramic substrate (1, 14) at the through-hole and at the recessed portion with a screw fastening torque of from 20 N·m to 25 N·m. providing a ceramic substrate (1, 14) comprising a through-hole for screw-fastening and a recessed portion for screw-fastening or for position registration provided on at least one edge surface thereof, the through-hole having a diameter of 1mm to 5mm, the recessed portion having a width of 1 mm to 5 mm and a depth of 1 mm to 5 mm, where the ceramic substrate (1, 14) being a silicon nitride substrate having a length (L1, L2) of one edge of 10 mm to 200 mm, a plate thickness of 0.2 mm to 1mm, characterised by a heat conductivity of 60 W/m·K or more, and a 3-point bending strength of 600 MPa or more at ambient temperature, and screw-fastening the ceramic substrate (1, 14) at the through-hole and at the recessed portion with a screw fastening torque of from 20 N·m to 25 N·m.
An object information acquiring apparatus, comprising: a plurality of detection elements configured to detect acoustic waves generated as a result of irradiation of light from a light source onto an object and to output electric signals; a supporting member configured to support the plurality of detection elements so that axes of directivity of at least a part of the plurality of detection elements gather; characterized in that the plurality of detection elements include a plurality of first detection elements having a predetermined directivity angle (α1) and a plurality of second detection elements having a directivity angle (α2) narrower than the predetermined directivity angle (α1); and the apparatus further comprises an inputting unit configured to receive an input of a measurement condition from a user; a selecting unit configured to select at least a part of the plurality of detection elements based on the measurement condition input by the user and based on the respective directivity angle of each of the detection elements; and a processing unit configured to acquire property information on the inside of the object, using electric signals output from the detection elements selected by the selecting unit. a plurality of detection elements configured to detect acoustic waves generated as a result of irradiation of light from a light source onto an object and to output electric signals; a supporting member configured to support the plurality of detection elements so that axes of directivity of at least a part of the plurality of detection elements gather; characterized in that the plurality of detection elements include a plurality of first detection elements having a predetermined directivity angle (α1) and a plurality of second detection elements having a directivity angle (α2) narrower than the predetermined directivity angle (α1); and the apparatus further comprises an inputting unit configured to receive an input of a measurement condition from a user; a selecting unit configured to select at least a part of the plurality of detection elements based on the measurement condition input by the user and based on the respective directivity angle of each of the detection elements; and a processing unit configured to acquire property information on the inside of the object, using electric signals output from the detection elements selected by the selecting unit.