An Integrated Airport Domain Awareness and Response System, comprising: a ground detection component having at least one of an optical detection capability, a motion detection capability and a radar detection capability positioned proximate to the airport domain and configured to detect a ground-based threat to the airport domain; an airspace detection component configured to determine a range and a track of a flight vehicle proximate to the airport domain and configured to detect an airborne threat to the airport domain; a ground threat defense component; an airspace threat defense component; and an integration component operably coupled to and configured to exchange information with: the ground detection component, the airspace detection component, the airspace threat defense component and the ground threat defense component, wherein the integration component is configured to receive information from the ground detection component and the airspace detection component, assess the threat, and determine a response; wherein the ground threat defense component is configured to disable the ground-based threat based upon the response determined by the integration component; and the airspace threat defense component is configured to disable the airborne threat based upon the response determined by the integration component; wherein the optical detection capability comprises at least one of a video motion detection camera, and a pan-tilt-zoom camera; wherein the motion detection capability comprises at least one of a thermal motion detection device and a vibration detection device; wherein the airspace detection component comprises an Air Traffic Control, ATC, system that provides radar-based surveillance proximate to the airport domain; and wherein the ground threat defense component comprises a non-lethal directed energy weapon, and the airspace threat defense component comprises a directed energy weapon configured to disable the airborne threat. a ground detection component having at least one of an optical detection capability, a motion detection capability and a radar detection capability positioned proximate to the airport domain and configured to detect a ground-based threat to the airport domain; an airspace detection component configured to determine a range and a track of a flight vehicle proximate to the airport domain and configured to detect an airborne threat to the airport domain; a ground threat defense component; an airspace threat defense component; and an integration component operably coupled to and configured to exchange information with: the ground detection component, the airspace detection component, the airspace threat defense component and the ground threat defense component, wherein the integration component is configured to receive information from the ground detection component and the airspace detection component, assess the threat, and determine a response; wherein the ground threat defense component is configured to disable the ground-based threat based upon the response determined by the integration component; and the airspace threat defense component is configured to disable the airborne threat based upon the response determined by the integration component; wherein the optical detection capability comprises at least one of a video motion detection camera, and a pan-tilt-zoom camera; wherein the motion detection capability comprises at least one of a thermal motion detection device and a vibration detection device; wherein the airspace detection component comprises an Air Traffic Control, ATC, system that provides radar-based surveillance proximate to the airport domain; and wherein the ground threat defense component comprises a non-lethal directed energy weapon, and the airspace threat defense component comprises a directed energy weapon configured to disable the airborne threat.