A compound according to Formula I or a pharmaceutically acceptable salt thereof, wherein Y-X is CH 2 -CH 2, -C O- or -CH 2 O- R2 is phenyl, alkyl, -heteroaryl, benzoyl, heteroarylcarbonyl, alkoxy, cycloalkyl, cycloalkoxy, all alkyl or alkoxy moieties of which may optionally be subsituted with one or more substituents selected from R10 and the phenyl or heteroaryl moieties of which may optionally be subsituted with one or more substituents selected from R12, or R2 is alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, cycloalkylcarbonyl, alkenoxy, cycloalkyl alkoxy, phenyl alkoxy or heteroaryl alkoxy; R6 is hydroxy or H, or R6 is alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, cycloalkyl alkoxy, cycloalkoxy, heterocycloalkyl alkoxy, halogen, cyano, the alkyl or alkoxy moieties of which may optionally be substituted with one or more substituents selected from R10, or R6 together with R7 is -O-(CH 2)n-O- in which n is 1-3 and in which the CH 2 moiety may optionally be substituted by one or more alkyl substituents, or R6 and R7 may be joined in a cycloalkyl ring; R7 is hydroxy, H, or R7 is alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, cycloalkyl, cycloalkyl alkoxy, cycloalkoxy, heterocycloalkyl alkoxy, heterocycloalkoxy, heterocycloalkylcarbonyl, (di) alkylaminocarbonyl or heterocycloalkyl, the alkyl, alkoxy or (hetero)cycloalkyl moieties of which may optionally be substituted with one or more substituents selected from R11,or R7 is heteroaryl, phenyl, phenyl alkoxy, heteroaryl alkoxy, the phenyl or heteroaryl moieties of which may optionally be substituted with one or more substituents selected from R11; R8 is H or alkoxy; R10 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, alkyl, aminocarbonyl or (di) alkylamino; R11 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, (di) alkyl]amino or alkyl; R12 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, alkyl, aminocarbonyl or (di) alkylamino; R13 is H or alkyl; R14 and R15 are independently H or alkyl, or R14 and R15 may be joined in a cycloalkyl ring. Y-X is CH 2 -CH 2, -C O- or -CH 2 O- R2 is phenyl, alkyl, -heteroaryl, benzoyl, heteroarylcarbonyl, alkoxy, cycloalkyl, cycloalkoxy, all alkyl or alkoxy moieties of which may optionally be subsituted with one or more substituents selected from R10 and the phenyl or heteroaryl moieties of which may optionally be subsituted with one or more substituents selected from R12, or R2 is alkenyl, alkynyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, cycloalkylcarbonyl, alkenoxy, cycloalkyl alkoxy, phenyl alkoxy or heteroaryl alkoxy; R6 is hydroxy or H, or R6 is alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, cycloalkyl alkoxy, cycloalkoxy, heterocycloalkyl alkoxy, halogen, cyano, the alkyl or alkoxy moieties of which may optionally be substituted with one or more substituents selected from R10, or R6 together with R7 is -O-(CH 2)n-O- in which n is 1-3 and in which the CH 2 moiety may optionally be substituted by one or more alkyl substituents, or R6 and R7 may be joined in a cycloalkyl ring; R7 is hydroxy, H, or R7 is alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, cycloalkyl, cycloalkyl alkoxy, cycloalkoxy, heterocycloalkyl alkoxy, heterocycloalkoxy, heterocycloalkylcarbonyl, (di) alkylaminocarbonyl or heterocycloalkyl, the alkyl, alkoxy or (hetero)cycloalkyl moieties of which may optionally be substituted with one or more substituents selected from R11,or R7 is heteroaryl, phenyl, phenyl alkoxy, heteroaryl alkoxy, the phenyl or heteroaryl moieties of which may optionally be substituted with one or more substituents selected from R11; R8 is H or alkoxy; R10 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, alkyl, aminocarbonyl or (di) alkylamino; R11 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, (di) alkyl]amino or alkyl; R12 is hydroxy, amino, halogen, cyano, nitro, trifluoromethyl, alkoxy, alkyl, aminocarbonyl or (di) alkylamino; R13 is H or alkyl; R14 and R15 are independently H or alkyl, or R14 and R15 may be joined in a cycloalkyl ring.