A method of mammalian vascular state scoring comprising: receiving, by a computer, vascular image data including a plurality of two-dimensional angiographic images, each of a plurality of vascular segments of a patient; and reconstructing in real time, via the computer, a computerized three-dimensional model representing at least a portion of the plurality of vascular segments with the vascular image data; creating, via the computer, an unstenosed computerized three-dimensional model from the computerized three-dimensional model; characterized in that the method includes for each potential lesion: analyzing, via the computer, the three-dimensional model of the plurality of vascular segments to determine locations of potential lesions by identifying portions along the plurality of vascular segments where at least one of a cross-sectional area and a diameter decrease below a threshold from an expected decrease based on at least one of a cross-sectional area and a diameter of adjacent portions of the plurality of vascular segments, determining, via the computer, a first vascular state scoring tool ("VSST") subscore based on a size of stenosis at the lesion location, determining, via the computer, a second VSST subscore based on a distance of the lesion location from a branch point in the plurality of vascular segments, calculating, via the computer, a total VSST score by combining the first VSST subscore and the second VSST subscore, and determine, via the computer, a severity of stenosis, for the potential lesion, based on a comparison of the at least one of the cross-sectional area and the diameter of the potential lesion in the computerized three-dimensional model to the at least one of the cross-sectional area and the diameter of the potential lesion in the unstenosed computerized three-dimensional model; and causing a display device to display the severity of stenosis in conjunction with the total VSST scores for each of the potential lesions. receiving, by a computer, vascular image data including a plurality of two-dimensional angiographic images, each of a plurality of vascular segments of a patient; and reconstructing in real time, via the computer, a computerized three-dimensional model representing at least a portion of the plurality of vascular segments with the vascular image data; creating, via the computer, an unstenosed computerized three-dimensional model from the computerized three-dimensional model; characterized in that the method includes for each potential lesion: analyzing, via the computer, the three-dimensional model of the plurality of vascular segments to determine locations of potential lesions by identifying portions along the plurality of vascular segments where at least one of a cross-sectional area and a diameter decrease below a threshold from an expected decrease based on at least one of a cross-sectional area and a diameter of adjacent portions of the plurality of vascular segments, determining, via the computer, a first vascular state scoring tool ("VSST") subscore based on a size of stenosis at the lesion location, determining, via the computer, a second VSST subscore based on a distance of the lesion location from a branch point in the plurality of vascular segments, calculating, via the computer, a total VSST score by combining the first VSST subscore and the second VSST subscore, and determine, via the computer, a severity of stenosis, for the potential lesion, based on a comparison of the at least one of the cross-sectional area and the diameter of the potential lesion in the computerized three-dimensional model to the at least one of the cross-sectional area and the diameter of the potential lesion in the unstenosed computerized three-dimensional model; and causing a display device to display the severity of stenosis in conjunction with the total VSST scores for each of the potential lesions. determining, via the computer, a first vascular state scoring tool ("VSST") subscore based on a size of stenosis at the lesion location, determining, via the computer, a second VSST subscore based on a distance of the lesion location from a branch point in the plurality of vascular segments, calculating, via the computer, a total VSST score by combining the first VSST subscore and the second VSST subscore, and determine, via the computer, a severity of stenosis, for the potential lesion, based on a comparison of the at least one of the cross-sectional area and the diameter of the potential lesion in the computerized three-dimensional model to the at least one of the cross-sectional area and the diameter of the potential lesion in the unstenosed computerized three-dimensional model; and causing a display device to display the severity of stenosis in conjunction with the total VSST scores for each of the potential lesions.