A sensor system comprising: at least one implantable light source; an implantable sensor attached to the at least one light source such that the at least one light source backlights the sensor, the implantable sensor comprising a plurality of reaction chambers located adjacent to the at least one light source, and at least one analyte permeable opening in communication with the plurality of reaction chambers, each of the plurality of reaction chambers comprising: one or two entrance/exit points, at least one luminescent dye configured to interact with a target and produce a luminescent signal when irradiated with light from the at least one light source, wherein signal changes in the luminescent signal are related to the concentration of the target; and a molecule that interacts with the target during interaction by the molecule with an analyte that permeates into the one or two entrance/exit points and diffuses into the reaction chamber, wherein the luminescent dye and the molecule are disposed within each of the plurality of reaction chambers, wherein the reaction chambers containing the luminescent dye and molecule are enclosed except for the one or two entrance/exit points of each reaction chamber; a probe comprising at least one detector configured to receive a luminescence of the sensor based on the luminescence signal, wherein the sensor is suitable to be located between the at least one light source and the probe; and a wire or a multitude of wires connected to the at least one light source to power the at least one light source, wherein the wire or multitude of wires are implantable, wherein the wire or multitude of wires can be utilized as a tether for retrieval of the light source and sensor. at least one implantable light source; an implantable sensor attached to the at least one light source such that the at least one light source backlights the sensor, the implantable sensor comprising a plurality of reaction chambers located adjacent to the at least one light source, and at least one analyte permeable opening in communication with the plurality of reaction chambers, each of the plurality of reaction chambers comprising: one or two entrance/exit points, at least one luminescent dye configured to interact with a target and produce a luminescent signal when irradiated with light from the at least one light source, wherein signal changes in the luminescent signal are related to the concentration of the target; and a molecule that interacts with the target during interaction by the molecule with an analyte that permeates into the one or two entrance/exit points and diffuses into the reaction chamber, wherein the luminescent dye and the molecule are disposed within each of the plurality of reaction chambers, wherein the reaction chambers containing the luminescent dye and molecule are enclosed except for the one or two entrance/exit points of each reaction chamber; a probe comprising at least one detector configured to receive a luminescence of the sensor based on the luminescence signal, wherein the sensor is suitable to be located between the at least one light source and the probe; and a wire or a multitude of wires connected to the at least one light source to power the at least one light source, wherein the wire or multitude of wires are implantable, wherein the wire or multitude of wires can be utilized as a tether for retrieval of the light source and sensor. one or two entrance/exit points, at least one luminescent dye configured to interact with a target and produce a luminescent signal when irradiated with light from the at least one light source, wherein signal changes in the luminescent signal are related to the concentration of the target; and a molecule that interacts with the target during interaction by the molecule with an analyte that permeates into the one or two entrance/exit points and diffuses into the reaction chamber, wherein the luminescent dye and the molecule are disposed within each of the plurality of reaction chambers, wherein the reaction chambers containing the luminescent dye and molecule are enclosed except for the one or two entrance/exit points of each reaction chamber; a probe comprising at least one detector configured to receive a luminescence of the sensor based on the luminescence signal, wherein the sensor is suitable to be located between the at least one light source and the probe; and a wire or a multitude of wires connected to the at least one light source to power the at least one light source, wherein the wire or multitude of wires are implantable, wherein the wire or multitude of wires can be utilized as a tether for retrieval of the light source and sensor.