mhurhangee/ep-ind-claims huggingface dataset:
Isolated nucleic acid encoding a leader operably linked to a nucleic acid sequence encoding a protein of interest, wherein the nucleic acid encoding the leader is fused to the N-terminus of the POI, which leader is selected from the group consisting of a) a signal peptide consisting of the 20 amino acids sequence of SEQ ID 1 or a functional variant thereof with one or two point mutations, and b) a signal peptide consisting of the 20 amino acids sequence selected from the group consisting of SEQ ID 2, 3, 4 and 5, wherein the signal peptide characterized by a 21 amino acids sequence that includes a C-terminal extension by an additional alanine is excluded, and; wherein the nucleic acid does not encode the amino acid sequence identified as SEQ ID 8, and wherein the signal peptide consisting of the amino acid sequence SEQ ID 2 fused with a polypeptide consisting of one immunoglobulin single variable domain is excluded. a) a signal peptide consisting of the 20 amino acids sequence of SEQ ID 1 or a functional variant thereof with one or two point mutations, and b) a signal peptide consisting of the 20 amino acids sequence selected from the group consisting of SEQ ID 2, 3, 4 and 5,
A patient interface comprising: a body portion sized and shaped to surround the nose and/or mouth of a user and adapted to create at least a substantial seal with the user's face; a mask frame, wherein the body portion is secured to the mask frame and the mask frame is configured to be held in place by a headgear assembly that wraps around the user's head; a coupling that permits the patient interface to be coupled to a gas delivery system; and a separate ball socket component that is coupled to the body portion or the mask frame, the ball socket component defining: a vent that allows the passage of gas from an interior of the body portion to an exterior of the body portion, the vent comprising a plurality of exit holes arranged in an array; a plenum chamber that receives the gas exiting the vent; and a ball socket for accepting a ball end of the coupling. a body portion sized and shaped to surround the nose and/or mouth of a user and adapted to create at least a substantial seal with the user's face; a mask frame, wherein the body portion is secured to the mask frame and the mask frame is configured to be held in place by a headgear assembly that wraps around the user's head; a coupling that permits the patient interface to be coupled to a gas delivery system; and a separate ball socket component that is coupled to the body portion or the mask frame, the ball socket component defining: a vent that allows the passage of gas from an interior of the body portion to an exterior of the body portion, the vent comprising a plurality of exit holes arranged in an array; a plenum chamber that receives the gas exiting the vent; and a ball socket for accepting a ball end of the coupling. a vent that allows the passage of gas from an interior of the body portion to an exterior of the body portion, the vent comprising a plurality of exit holes arranged in an array; a plenum chamber that receives the gas exiting the vent; and a ball socket for accepting a ball end of the coupling.
A marine or bunker fuel composition having increased compatibility with commercial marine or bunker fuels, said composition having at least three of the following enumerated properties: a Bureau of Mines Compatibility Index (BMCI) index from 40 to 100; a difference between a BMCI index and a Toluene Equivalence value of 15 to 50; an asphaltene content from 1.0 wt% to 5.5 wt%; a Micro Carbon Residue content from 2.0 wt% to 8.0 wt%; a sulfur content from 4000 wppm to 5000 wppm; a boiling point distribution wherein a T0.5 is 100°C to 220°C, a T10 is 220°C to 320°C, a T50 is 300°C to 430°C, and/or a T90 is 360°C to 510°C; a density at 15°C of 0.88 g/cm3 to 0.99 g/cm3; and a kinematic viscosity at 50°C of 4.5 cSt to 220 cSt. a Bureau of Mines Compatibility Index (BMCI) index from 40 to 100; a difference between a BMCI index and a Toluene Equivalence value of 15 to 50; an asphaltene content from 1.0 wt% to 5.5 wt%; a Micro Carbon Residue content from 2.0 wt% to 8.0 wt%; a sulfur content from 4000 wppm to 5000 wppm; a boiling point distribution wherein a T0.5 is 100°C to 220°C, a T10 is 220°C to 320°C, a T50 is 300°C to 430°C, and/or a T90 is 360°C to 510°C; a density at 15°C of 0.88 g/cm3 to 0.99 g/cm3; and a kinematic viscosity at 50°C of 4.5 cSt to 220 cSt.
A refrigerator comprising: an imaging unit generating a goods loading/unloading video through video recording of storage goods loaded into or unloaded from the refrigerator when a door of the refrigerator opens; a data storage unit storing the goods loading/unloading video, goods information that may be stored in the refrigerator, and storage items information; a control unit obtaining and storing a background image from the goods loading/unloading video, recognizing loading/unloading of goods based on an optical flow detected through vision recognition from the goods loading/unloading video, recognizing the goods in the goods loading/unloading video based on the goods loading/unloading video and the background image in order to separate goods and a user's arm regions when the loading/unloading of goods is recognized, and updating the storage items information in the refrigerator based on recognition result of the goods and the goods information stored in the data storage unit; and a display unit displaying a managed state of storage items for a user based on the updated storage items information, wherein the control unit recognizes the loading/unloading of goods based on directions of motion vectors detected through the optical flow, which are opposite when the user's arm enters and then leaves the refrigerator, and wherein, when the recognition result of the goods is negative, the control unit receives a user input for the goods from an input unit including at least one of a voice input unit, a touch panel, or keypad. an imaging unit generating a goods loading/unloading video through video recording of storage goods loaded into or unloaded from the refrigerator when a door of the refrigerator opens; a data storage unit storing the goods loading/unloading video, goods information that may be stored in the refrigerator, and storage items information; a control unit obtaining and storing a background image from the goods loading/unloading video, recognizing loading/unloading of goods based on an optical flow detected through vision recognition from the goods loading/unloading video, recognizing the goods in the goods loading/unloading video based on the goods loading/unloading video and the background image in order to separate goods and a user's arm regions when the loading/unloading of goods is recognized, and updating the storage items information in the refrigerator based on recognition result of the goods and the goods information stored in the data storage unit; and a display unit displaying a managed state of storage items for a user based on the updated storage items information, wherein the control unit recognizes the loading/unloading of goods based on directions of motion vectors detected through the optical flow, which are opposite when the user's arm enters and then leaves the refrigerator, and wherein, when the recognition result of the goods is negative, the control unit receives a user input for the goods from an input unit including at least one of a voice input unit, a touch panel, or keypad.
An image forming apparatus, comprising: image forming means configured to form an image on a sheet; control means configured to control operation of the image forming means; and storage means configured to store information indicating that a function of the image forming means is restricted, characterized in that the control means is further configured to: not execute an initialization operation corresponding to the restricted function of the image forming means in a case where the storage means stores the information and the image forming apparatus activates from a power saving state in which an electric power supply to the control means is stopped, execute the initialization operation in a case where the storage means does not store the information and the image forming apparatus activates from the power saving state. image forming means configured to form an image on a sheet; control means configured to control operation of the image forming means; and storage means configured to store information indicating that a function of the image forming means is restricted, characterized in that the control means is further configured to: not execute an initialization operation corresponding to the restricted function of the image forming means in a case where the storage means stores the information and the image forming apparatus activates from a power saving state in which an electric power supply to the control means is stopped, execute the initialization operation in a case where the storage means does not store the information and the image forming apparatus activates from the power saving state. not execute an initialization operation corresponding to the restricted function of the image forming means in a case where the storage means stores the information and the image forming apparatus activates from a power saving state in which an electric power supply to the control means is stopped, execute the initialization operation in a case where the storage means does not store the information and the image forming apparatus activates from the power saving state.
A method for the application of a sealant layer in a tyre comprising a deposition step, in which a sealant layer is deposited on a free surface of an inner liner layer facing an inner cavity of the tyre; said method being characterized in that it comprises a step of reduction of the stickiness, in which a surface exposed to the air of said sealant layer deposited on said inner liner layer is subject to the direct action of a UV radiation.
An ion propulsion system comprising first and second power controllers, first and second ion thrusters and a first switch assembly having at least first and second switching states, wherein when said first and second power controllers are on, said first and second ion thrusters receive power from said first and second power controllers respectively via said first switch assembly when said first switch assembly is in said first switching state and receive power from said second and first power controllers respectively via said first switch assembly when said first switch assembly is in said second switching state, and wherein said first switch assembly comprises a first body which is movable and a first multiplicity of switches which change state in unison when said first body changes position, said first switch assembly being in said first switching state when said first body is in a first position and being in said second switching state when said first body is in a second position.
A method for reducing memory subsystem power, the method comprising: a system resource manager determining memory performance requirements for a plurality of memory clients and providing the memory performance requirements to a double data rate, DDR, subsystem, the DDR subsystem and the system resource manager residing on a system on chip, SoC, electrically coupled to a dynamic random access memory, DRAM; determining with the DDR subsystem a cache hit rate of each of the plurality of memory clients associated with a system cache residing on the DDR subsystem; and the DDR subsystem adjusting access to the DRAM based on the memory performance requirements and the cache hit rates of the plurality of memory clients, characterised in that the DDR subsystem adjusting access to the DRAM comprises: adjusting a system cache prefetch size based on a DDR clock frequency, and increasing a system cache prefetch size to mitigate latency when the DDR clock frequency reaches a programmable threshold. a system resource manager determining memory performance requirements for a plurality of memory clients and providing the memory performance requirements to a double data rate, DDR, subsystem, the DDR subsystem and the system resource manager residing on a system on chip, SoC, electrically coupled to a dynamic random access memory, DRAM; determining with the DDR subsystem a cache hit rate of each of the plurality of memory clients associated with a system cache residing on the DDR subsystem; and the DDR subsystem adjusting access to the DRAM based on the memory performance requirements and the cache hit rates of the plurality of memory clients, characterised in that the DDR subsystem adjusting access to the DRAM comprises: adjusting a system cache prefetch size based on a DDR clock frequency, and increasing a system cache prefetch size to mitigate latency when the DDR clock frequency reaches a programmable threshold.
A use of genetically engineered strains in the preparation of steroidal compounds, characterized in that, the genetically engineered strains lack of hydroxyacyl-coenzyme A dehydrogenase gene, and the steroidal compounds comprise: 22-hydroxy-23,24-bisnorchol-1,4-dien-3-one, 22-hydroxy-23,24-bisnorchol-4-ene-3-one and 9α,22-dihydroxy-23,24-bisnorcho1-4-ene-3-one; wherein, said hydroxyacyl-coenzyme A dehydrogenase gene encodes a protein (i) or (ii) as follows: (i) having an amino acid sequence according to SEQ ID NO 2; (ii) derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by (i) and having the same function as that of the protein of (i). 22-hydroxy-23,24-bisnorchol-1,4-dien-3-one, 22-hydroxy-23,24-bisnorchol-4-ene-3-one and 9α,22-dihydroxy-23,24-bisnorcho1-4-ene-3-one; wherein, said hydroxyacyl-coenzyme A dehydrogenase gene encodes a protein (i) or (ii) as follows: (i) having an amino acid sequence according to SEQ ID NO 2; (ii) derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by (i) and having the same function as that of the protein of (i). (i) having an amino acid sequence according to SEQ ID NO 2; (ii) derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by (i) and having the same function as that of the protein of (i).
A system of managing power distribution units (202, 204, 206, 208) comprising: one or more master rack Power Distribution Units, PDU's, each master rack PDU of the one or more master rack PDU's including a port coupled to a network, and being configured to receive short-range wireless signals; and a plurality of child rack PDU's, each child rack PDU of the plurality of child rack PDU's including a port and being configured to transmit short-range wireless signals including data measurements; characterised in that the system consists of a plurality of identical rack PDUs, the wireless interface of each rack PDU operating in the same way; each rack PDU is configured to operate as a master rack PDU responsive to the port being connected to the network, to receive the data measurements in the short-range wireless signals transmitted by the plurality of child rack PDU's, and to transmit the data measurements to a computer over the network via the port, and each rack PDU is configured to operate as a child rack PDU responsive to the port not being connected to the network. one or more master rack Power Distribution Units, PDU's, each master rack PDU of the one or more master rack PDU's including a port coupled to a network, and being configured to receive short-range wireless signals; and a plurality of child rack PDU's, each child rack PDU of the plurality of child rack PDU's including a port and being configured to transmit short-range wireless signals including data measurements; characterised in that the system consists of a plurality of identical rack PDUs, the wireless interface of each rack PDU operating in the same way; each rack PDU is configured to operate as a master rack PDU responsive to the port being connected to the network, to receive the data measurements in the short-range wireless signals transmitted by the plurality of child rack PDU's, and to transmit the data measurements to a computer over the network via the port, and each rack PDU is configured to operate as a child rack PDU responsive to the port not being connected to the network.
A method for decoding an encoded optical signal comprising at least two different states, such as "0"-states and "1"-states, the optical signal being frequency and amplitude modulated such that the different states are separated in frequency and amplitude, the method comprising the steps of: • combining said encoded optical signal with light from a local oscillator configured with a local oscillator frequency; • converting the combined local oscillator and encoded optical signal into one or more electrical signals by means of at least one opto-electrical converter having a predefined frequency bandwidth, thereby providing an amplified and encoded electrical signal having one or more encoded signal current(s), where one type of states have a higher oscillation frequency than other type of states; • rectifying the encoded signal current(s), thereby obtaining an encoded power spectrum, wherein said power spectrum has different states, such as "0"-states and "1"-states, with different power levels such that they can be discriminated, said local oscillator frequency is defined by a positive local oscillator frequency-offset from the frequency of one of the states in said encoded optical signal, characterized in that said local oscillator frequency-offset is selected to be between 1 and 1.5 times the predefined frequency bandwidth of the opto-electrical converter. • combining said encoded optical signal with light from a local oscillator configured with a local oscillator frequency; • converting the combined local oscillator and encoded optical signal into one or more electrical signals by means of at least one opto-electrical converter having a predefined frequency bandwidth, thereby providing an amplified and encoded electrical signal having one or more encoded signal current(s), where one type of states have a higher oscillation frequency than other type of states; • rectifying the encoded signal current(s), thereby obtaining an encoded power spectrum, wherein said power spectrum has different states, such as "0"-states and "1"-states, with different power levels such that they can be discriminated,
An in vitro method for preparing lymphoid progenitors, said method comprising the step of culturing hematopoietic stem cells (HSCs) or Multipotent progenitor cells (MPPs) in an appropriate culture medium comprising an effective amount of the five cytokines SCF, IL-3, IL-6, IL-7, Flt-3L and an effective amount of the chemokine CXCL12.
Mixing device for mixing exhaust gas from a combustion engine of a vehicle with a solution for lowering the content of nitrogen oxides in the exhaust gas, wherein the mixing device comprises a casing with an exhaust inlet, an exhaust outlet and a corner region in which an exhaust gas flow is diverted towards the exhaust outlet, wherein the corner region has an opening for a dosing unit, and wherein the mixing device comprises a flow guide arranged within the casing, which is configured to divide a total of the exhaust gas flow into a first exhaust gas stream and a second exhaust gas stream, characterized in that a gap for the second exhaust gas stream is formed between the flow guide and a side wall of the casing, in which the opening for the dosing unit is located, wherein an end region of the flow guide is arranged upstream of the opening for the dosing unit and the casing has a bend in which the exhaust gas flow is diverted from the exhaust inlet towards the corner region, wherein an upstream end region of the flow guide reaches into the bend and the corner region provides a flat surface for the installation of the dosing unit.
A process for preparing a flexible packaging material comprising: - printing a liquid electrophotographic printing ink composition onto a surface of a first flexible substrate coated with a primer resin; - extruding a thermally activatable laminating material onto a surface of a second flexible substrate, wherein the thermally activatable laminating material is a polymer having an ester of acrylic or methacrylic acid content greater than or equal to 17% by weight; and - contacting, under conditions of temperature greater or equal to 50°C, the surface of the second flexible substrate on which the thermally activatable laminating material is deposited with the surface of the first flexible substrate printed with the liquid electrophotographic printing ink composition. - printing a liquid electrophotographic printing ink composition onto a surface of a first flexible substrate coated with a primer resin; - extruding a thermally activatable laminating material onto a surface of a second flexible substrate, wherein the thermally activatable laminating material is a polymer having an ester of acrylic or methacrylic acid content greater than or equal to 17% by weight; and - contacting, under conditions of temperature greater or equal to 50°C, the surface of the second flexible substrate on which the thermally activatable laminating material is deposited with the surface of the first flexible substrate printed with the liquid electrophotographic printing ink composition.
A surgical cutting and fastening instrument comprising: an end effector comprising a moveable cutting instrument for cutting an object positioned in the end effector; a main drive shaft assembly (48,50,52) connected to the end effector; and a handle connected to the main drive shaft assembly, (48,50,52) wherein the handle comprises: a gear drive train connected to the main drive shaft assembly (48,50,52); a motor for actuating the gear drive train; and a firing trigger for actuating the motor and connected to the gear drive train such that the loading force on the firing trigger is related to the loading force experience by the cutting instrument in the end effector; wherein the gear drive train comprises a helical gear drum and a ring threaded on the helical gear drum, and further comprising an arm connecting the firing trigger to the ring. an end effector comprising a moveable cutting instrument for cutting an object positioned in the end effector; a main drive shaft assembly (48,50,52) connected to the end effector; and a handle connected to the main drive shaft assembly, (48,50,52) wherein the handle comprises: a gear drive train connected to the main drive shaft assembly (48,50,52); a motor for actuating the gear drive train; and a firing trigger for actuating the motor and connected to the gear drive train such that the loading force on the firing trigger is related to the loading force experience by the cutting instrument in the end effector; a gear drive train connected to the main drive shaft assembly (48,50,52); a motor for actuating the gear drive train; and a firing trigger for actuating the motor and connected to the gear drive train such that the loading force on the firing trigger is related to the loading force experience by the cutting instrument in the end effector;