A system configured to inexsufflate a subject, the system comprising: a pressure generator configured to generate and control delivery of a pressurized flow of breathable gas to an airway of the subject; one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; and one or more processors configured to execute computer program modules, the computer program modules comprising: a target module configured to obtain a target tidal flow rate and a target tidal volume, to determine when the target tidal volume has been reached during an individual insufflation based on the output signals, to monitor a tidal flow rate based on the output signals, and to compare the monitored tidal flow rate with the target tidal flow rate; and a control module configured to control the pressure generator, based on the output signals, to control an insufflation pressure of the pressurized flow of breathable gas during an insufflation of the subject to maintain the tidal flow rate of the pressurized flow of breathable gas substantially at the target tidal flow rate until the target tidal volume is reached for the insufflation, wherein, responsive to a determination by the target module that the target tidal volume has substantially been reached, the control module is configured to control the pressure generator to evacuate the gas from the airway of the subject; characterized in that: the computer program modules further comprise a dwell time module configured to obtain a dwell time, and wherein the control module is configured to control the pressure generator to maintain the tidal volume in the airway of the subject during the dwell time such that the tidal flow rate is at or near zero during the dwell time, before causing the gas to be evacuated from the airway of the subject. a pressure generator configured to generate and control delivery of a pressurized flow of breathable gas to an airway of the subject; one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; and one or more processors configured to execute computer program modules, the computer program modules comprising: a target module configured to obtain a target tidal flow rate and a target tidal volume, to determine when the target tidal volume has been reached during an individual insufflation based on the output signals, to monitor a tidal flow rate based on the output signals, and to compare the monitored tidal flow rate with the target tidal flow rate; and a control module configured to control the pressure generator, based on the output signals, to control an insufflation pressure of the pressurized flow of breathable gas during an insufflation of the subject to maintain the tidal flow rate of the pressurized flow of breathable gas substantially at the target tidal flow rate until the target tidal volume is reached for the insufflation, wherein, responsive to a determination by the target module that the target tidal volume has substantially been reached, the control module is configured to control the pressure generator to evacuate the gas from the airway of the subject; characterized in that: the computer program modules further comprise a dwell time module configured to obtain a dwell time, and wherein the control module is configured to control the pressure generator to maintain the tidal volume in the airway of the subject during the dwell time such that the tidal flow rate is at or near zero during the dwell time, before causing the gas to be evacuated from the airway of the subject. a target module configured to obtain a target tidal flow rate and a target tidal volume, to determine when the target tidal volume has been reached during an individual insufflation based on the output signals, to monitor a tidal flow rate based on the output signals, and to compare the monitored tidal flow rate with the target tidal flow rate; and a control module configured to control the pressure generator, based on the output signals, to control an insufflation pressure of the pressurized flow of breathable gas during an insufflation of the subject to maintain the tidal flow rate of the pressurized flow of breathable gas substantially at the target tidal flow rate until the target tidal volume is reached for the insufflation, wherein, responsive to a determination by the target module that the target tidal volume has substantially been reached, the control module is configured to control the pressure generator to evacuate the gas from the airway of the subject; characterized in that: the computer program modules further comprise a dwell time module configured to obtain a dwell time, and wherein the control module is configured to control the pressure generator to maintain the tidal volume in the airway of the subject during the dwell time such that the tidal flow rate is at or near zero during the dwell time, before causing the gas to be evacuated from the airway of the subject.