A method for determining the integrity of the human genome of a sample to be analysed by whole genome amplification and/or the quality of a library of DNA sequences obtained by deterministic restriction site whole genome amplification (DRS-WGA) of the human genome of the sample comprising the steps of: (a) providing the library of DNA sequences, (b) amplifying the library of DNA sequences by PCR using: - at least one first primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the D5S2117 region of chromosome 5q of the genome, - at least one second primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing exons 2 and 3 of the TRP53 gene of the genome, and - at least one third primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the KRT19 pseudo-gene 1 of the genome, the step of amplifying giving rise to a first PCR product from 50 bp to 1000 bp, a second PCR product from 50 bp to 1000 bp having a size other than the first PCR product, and a third PCR product from 50 bp to 1000 bp having a size other than the first and second PCR products; (c) detecting the first, second and third PCR products; (d) correlating the presence of the first, second and third PCR products with the integrity of the genome of the sample and/or the quality of the library of DNA sequences. (a) providing the library of DNA sequences, (b) amplifying the library of DNA sequences by PCR using: - at least one first primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the D5S2117 region of chromosome 5q of the genome, - at least one second primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing exons 2 and 3 of the TRP53 gene of the genome, and - at least one third primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the KRT19 pseudo-gene 1 of the genome, the step of amplifying giving rise to a first PCR product from 50 bp to 1000 bp, a second PCR product from 50 bp to 1000 bp having a size other than the first PCR product, and a third PCR product from 50 bp to 1000 bp having a size other than the first and second PCR products; - at least one first primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the D5S2117 region of chromosome 5q of the genome, - at least one second primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing exons 2 and 3 of the TRP53 gene of the genome, and - at least one third primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and encompassing the KRT19 pseudo-gene 1 of the genome, (c) detecting the first, second and third PCR products; (d) correlating the presence of the first, second and third PCR products with the integrity of the genome of the sample and/or the quality of the library of DNA sequences.