An implantable medical device comprising: a cylindrical intraluminal scaffold (10, 12) which comprises a plurality of struts (18; 22) interconnected by ductile hinges, and which is expandable from a first diameter for delivery into a vessel to a second diameter for expanding the vessel by deformation of the hinges while the struts remain undeformed, the intraluminal scaffold having a luminal surface and an abluminal surface, the distance between the luminal surface and the abluminal surface defining the wall thickness of the intraluminal scaffold, the intraluminal scaffold also having a plurality of openings (30; 902) in the struts, a first coating comprising an anti-thrombotic agent having a first electric charge which is affixed to at least a portion of at least one surface of the scaffold and to the surfaces of the openings, and a second coating comprising a polymeric conjugate having a second electric charge affixed to the first coating only in the plurality of openings, the polymeric conjugate comprising a first component comprising poly(lactic-co-glycolic acid) and a second component selected from the group consisting of an oligomeric arginine peptide, polylysine, poly(arginine), protamine, poly(dimethylaminoethyl) methacrylate, poly(dimethylaminoethyl acrylate) and poly(ethyleneimine), and the second electric charge being opposite charge to the first electric charge, characterised in that the device includes a drug delivery matrix (912, 914, 916) which includes at least one therapeutic agent and a polymer excipient, and which is deposited in at least one of the plurality of openings, so that the second coating is configured as an intermediate layer between the first coating and the drug delivery matrix. a cylindrical intraluminal scaffold (10, 12) which comprises a plurality of struts (18; 22) interconnected by ductile hinges, and which is expandable from a first diameter for delivery into a vessel to a second diameter for expanding the vessel by deformation of the hinges while the struts remain undeformed, the intraluminal scaffold having a luminal surface and an abluminal surface, the distance between the luminal surface and the abluminal surface defining the wall thickness of the intraluminal scaffold, the intraluminal scaffold also having a plurality of openings (30; 902) in the struts, a first coating comprising an anti-thrombotic agent having a first electric charge which is affixed to at least a portion of at least one surface of the scaffold and to the surfaces of the openings, and a second coating comprising a polymeric conjugate having a second electric charge affixed to the first coating only in the plurality of openings, the polymeric conjugate comprising a first component comprising poly(lactic-co-glycolic acid) and a second component selected from the group consisting of an oligomeric arginine peptide, polylysine, poly(arginine), protamine, poly(dimethylaminoethyl) methacrylate, poly(dimethylaminoethyl acrylate) and poly(ethyleneimine), and the second electric charge being opposite charge to the first electric charge, characterised in that the device includes a drug delivery matrix (912, 914, 916) which includes at least one therapeutic agent and a polymer excipient, and which is deposited in at least one of the plurality of openings, so that the second coating is configured as an intermediate layer between the first coating and the drug delivery matrix.