A method of extracting a vaginal biological sample for monitoring a health condition of a subject, said method comprising: (a) using a sample collector to non-invasively collect a vaginal biological sample from a vaginal canal of said subject, wherein said sample collector collects and retains said vaginal biological sample from said vaginal canal; (b) bringing said sample collector in proximity to an extractor comprising (i) a first chamber configured to receive said sample collector via an opening and, (ii) a second chamber adjacent to said first chamber, wherein said second chamber comprises a reagent compartment capable of retaining a solution, wherein at least one of said first chamber and said second chamber is breakable in response to a compression force, wherein the extractor is configured to be enclosed in an outer shell, wherein upon enclosure, said outer shell is configured to apply said compression force towards at least one of said first chamber and said second chamber; (c) depositing said sample collector through said opening into said first chamber; and (d) closing said outer shell, wherein the closing generates the compression force on said first chamber or said second chamber, that is breakable and breaks in response to the compression force, to bring said first chamber in fluid communication with said second chamber, thereby bringing said solution into contact with said vaginal biological sample to form a mixture of said solution with said vaginal biological sample. (a) using a sample collector to non-invasively collect a vaginal biological sample from a vaginal canal of said subject, wherein said sample collector collects and retains said vaginal biological sample from said vaginal canal; (b) bringing said sample collector in proximity to an extractor comprising (i) a first chamber configured to receive said sample collector via an opening and, (ii) a second chamber adjacent to said first chamber, wherein said second chamber comprises a reagent compartment capable of retaining a solution, wherein at least one of said first chamber and said second chamber is breakable in response to a compression force, wherein the extractor is configured to be enclosed in an outer shell, wherein upon enclosure, said outer shell is configured to apply said compression force towards at least one of said first chamber and said second chamber; (i) a first chamber configured to receive said sample collector via an opening and, (ii) a second chamber adjacent to said first chamber, wherein said second chamber comprises a reagent compartment capable of retaining a solution, wherein at least one of said first chamber and said second chamber is breakable in response to a compression force, wherein the extractor is configured to be enclosed in an outer shell, wherein upon enclosure, said outer shell is configured to apply said compression force towards at least one of said first chamber and said second chamber; (c) depositing said sample collector through said opening into said first chamber; and (d) closing said outer shell, wherein the closing generates the compression force on said first chamber or said second chamber, that is breakable and breaks in response to the compression force, to bring said first chamber in fluid communication with said second chamber, thereby bringing said solution into contact with said vaginal biological sample to form a mixture of said solution with said vaginal biological sample.