A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is 3-hydroxypropyl; R 2 is H, C 1 -C 6 alkyl, C 2 -C 6 hydroxyalkyl, cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 1 -C 6 alkoxy; R 3 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 acyl, C 3 -C 10 cycloalkyl, halo, hydroxyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino,,-C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano each of which is optionally substituted with 1-4 R 6; R 4 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, alkylthio, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O,5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, each of which is optionally substituted with 1-4 R 7; R 5 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, alkylthio, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O,5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-, -C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, each of which is optionally substituted with 1-4 R 7; wherein at least two of R 3, R 4 and R 5 are not H; each R 6 is independently C 1 -C 3 alkyl, halo, hydroxyl, or amino; and each R 7 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkyloxy, aryloxy, arylalkoxy, heteroaryloxy, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-, -C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, nitro, or cyano. R 1 is 3-hydroxypropyl; R 2 is H, C 1 -C 6 alkyl, C 2 -C 6 hydroxyalkyl, cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 1 -C 6 alkoxy; R 3 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 acyl, C 3 -C 10 cycloalkyl, halo, hydroxyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino,,-C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano each of which is optionally substituted with 1-4 R 6; R 4 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, alkylthio, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O,5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, each of which is optionally substituted with 1-4 R 7; R 5 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, alkylthio, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O,5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-, -C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, each of which is optionally substituted with 1-4 R 7; wherein at least two of R 3, R 4 and R 5 are not H; each R 6 is independently C 1 -C 3 alkyl, halo, hydroxyl, or amino; and each R 7 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkyloxy, aryloxy, arylalkoxy, heteroaryloxy, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-, -C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, nitro, or cyano.