Microtome system (100, 200, 300) for cutting sections from a specimen, the microtome system (100, 200, 300) comprising: - a knife having a knife edge configured to cut a section from the specimen, - a knife holder holding said knife, - a specimen holder configured to hold the specimen, - a light source, - a first actor (260.1), - a detector, and - a controller; wherein the knife holder and the specimen holder are configured to be moveable relative to one another in a cutting direction (c); wherein the knife holder or the specimen holder is mounted rotatably about a first axis (z, z'); wherein the first actor (260.1) is configured to cause a rotation of the knife holder or specimen holder about the first axis (z'); wherein the light source is configured to illuminate a gap between a front face of the specimen when held by the specimen holder and the knife edge, in order to generate a light gap, wherein the detector is configured to detect at least one geometric feature (W, φ) of the light gap, and wherein the controller is configured to a) automatically align the knife edge with the front face of the specimen by controlling the first actor (260.1) depending on the detected at least one geometric feature (W, φ) of the light gap, and/or b) provide instructions to a user depending on the detected at least one geometric feature (W, φ) of the light gap on how to manually control the first actor (260.1) in order to align the knife edge with the front face of the specimen, characterised in that the controller is configured to control the first actor (260.1) for arranging the knife edge parallel to the front face of the specimen such that the at least one geometric feature of the detected light gap comprises a constant width along a light gap length. - a knife having a knife edge configured to cut a section from the specimen, - a knife holder holding said knife, - a specimen holder configured to hold the specimen, - a light source, - a first actor (260.1), - a detector, and - a controller; wherein the knife holder and the specimen holder are configured to be moveable relative to one another in a cutting direction (c); wherein the knife holder or the specimen holder is mounted rotatably about a first axis (z, z'); wherein the first actor (260.1) is configured to cause a rotation of the knife holder or specimen holder about the first axis (z'); wherein the light source is configured to illuminate a gap between a front face of the specimen when held by the specimen holder and the knife edge, in order to generate a light gap, wherein the detector is configured to detect at least one geometric feature (W, φ) of the light gap, and wherein the controller is configured to a) automatically align the knife edge with the front face of the specimen by controlling the first actor (260.1) depending on the detected at least one geometric feature (W, φ) of the light gap, and/or b) provide instructions to a user depending on the detected at least one geometric feature (W, φ) of the light gap on how to manually control the first actor (260.1) in order to align the knife edge with the front face of the specimen, characterised in that the controller is configured to control the first actor (260.1) for arranging the knife edge parallel to the front face of the specimen such that the at least one geometric feature of the detected light gap comprises a constant width along a light gap length. wherein the knife holder and the specimen holder are configured to be moveable relative to one another in a cutting direction (c); wherein the knife holder or the specimen holder is mounted rotatably about a first axis (z, z'); wherein the first actor (260.1) is configured to cause a rotation of the knife holder or specimen holder about the first axis (z'); wherein the light source is configured to illuminate a gap between a front face of the specimen when held by the specimen holder and the knife edge, in order to generate a light gap, wherein the detector is configured to detect at least one geometric feature (W, φ) of the light gap, and wherein the controller is configured to a) automatically align the knife edge with the front face of the specimen by controlling the first actor (260.1) depending on the detected at least one geometric feature (W, φ) of the light gap, and/or b) provide instructions to a user depending on the detected at least one geometric feature (W, φ) of the light gap on how to manually control the first actor (260.1) in order to align the knife edge with the front face of the specimen, characterised in that the controller is configured to control the first actor (260.1) for arranging the knife edge parallel to the front face of the specimen such that the at least one geometric feature of the detected light gap comprises a constant width along a light gap length. a) automatically align the knife edge with the front face of the specimen by controlling the first actor (260.1) depending on the detected at least one geometric feature (W, φ) of the light gap, and/or b) provide instructions to a user depending on the detected at least one geometric feature (W, φ) of the light gap on how to manually control the first actor (260.1) in order to align the knife edge with the front face of the specimen, characterised in that the controller is configured to control the first actor (260.1) for arranging the knife edge parallel to the front face of the specimen such that the at least one geometric feature of the detected light gap comprises a constant width along a light gap length.