mhurhangee/ep-ind-claims huggingface dataset:
Coupling agent comprising at least one carbodiimide based on compounds of the formula R'-(-N=C=N-R-) m -R", in which m is an integer from 1 to 500, R = C 1 -C 18 -alkylene, C 5 -C 18 -cycloalkylene, arylene and/or C 7 -C 18 -aralkylene, R' = R-NCO, R-NHCONHR 1, R-NHCONR 1 R 2 or R-NHCOOR 3 and R"= -NCO, -NHCONHR 1, -NHCONR 1 R 2 or -NHCOO R 3, where R 1 and R 2 in R' are mutually independently identical or different and are a C 1 -C 6 -alkyl moiety, C 6 -C 10 -cycloalkyl moiety or C 7 -C 18 -aralkyl moiety, and R 3 is as defined for R 1 or is a polyester moiety or a polyamide moiety or -(CH 2) 1 -(O-(CH 2) k -O) g -R 4, -C 6 H 4 or -C 6 H 3 -((CH 2) h -C 6 H 4) y where l = from 1 to 3, k = from 1 to 3, g = from 0 to 12, h = from 1 to 2 and y = from 1 to 50, and R 4 = H or C 1 -C 4 -alkyl, where these have been surface-deactivated via reaction with at least one amine.
A pretensioner comprising: a drive wheel provided with a plurality of engaging teeth (41, 411, 412) for rotating a spool, the spool for winding up a webbing for fastening a passenger; and a cylindrically shaped elongated resin component that is adapted to transmit power to the drive wheel during an emergency, characterized in that by identifying, in advance, a position of a center line of the elongated resin component, a diameter of the elongated resin component, a position of a rotation center of the drive wheel, and a number of the plurality of engaging teeth (41, 411, 412), the plurality of teeth (41, 411, 412) is adapted to be positioned in an initial state such that, when one engaging tooth is caused to contact a tip (51a, 51f) of the cylindrically shaped elongated resin component so that an angle α formed by a gear tooth surface of the one engaging tooth and a front end face of the elongated resin component fulfils the constraint - 3 degrees ≤ α ≤ +3 degrees, another engaging tooth adjacent to the one engaging tooth in a direction opposite to a rotation direction contacts a peripheral side surface of the cylindrically shaped elongated resin component. a drive wheel provided with a plurality of engaging teeth (41, 411, 412) for rotating a spool, the spool for winding up a webbing for fastening a passenger; and a cylindrically shaped elongated resin component that is adapted to transmit power to the drive wheel during an emergency, characterized in that by identifying, in advance, a position of a center line of the elongated resin component, a diameter of the elongated resin component, a position of a rotation center of the drive wheel, and a number of the plurality of engaging teeth (41, 411, 412), the plurality of teeth (41, 411, 412) is adapted to be positioned in an initial state such that, when one engaging tooth is caused to contact a tip (51a, 51f) of the cylindrically shaped elongated resin component so that an angle α formed by a gear tooth surface of the one engaging tooth and a front end face of the elongated resin component fulfils the constraint - 3 degrees ≤ α ≤ +3 degrees, another engaging tooth adjacent to the one engaging tooth in a direction opposite to a rotation direction contacts a peripheral side surface of the cylindrically shaped elongated resin component.
Identification document (1, 11, 21, 31, 41, 51) comprising: a non-transparent core (6, 46), and one or more layers of a transparent material arranged on at least a back or a front surface of said core, characterized in that the identification document (1, 11, 21, 31) has a translucent security element in a region where the thickness of the non-transparent core (6, 46) material is smaller as compared to the thickness of the non-transparent core material in other parts of said core (6, 46). a non-transparent core (6, 46), and one or more layers of a transparent material arranged on at least a back or a front surface of said core,
An engine control apparatus, comprising: a temperature sensor configured to detect engine-related temperature information; a first calculator configured to calculate a first limit output value of an engine based on the engine-related temperature information inputted from the temperature sensor; an oil pressure sensor configured to detect an oil pressure value of the engine; an anticipator configured to predict an oil pressure in a turbocharger based on the oil pressure value from the oil pressure sensor; a second calculator configured to calculate a second limit output value of the engine based on the predicted oil pressure value in the turbocharger; a determiner configured to determine one of the first and second limit output values inputted from the first and second calculators as an optimal limit output value of the engine; and an engine controller configured to control an output of the engine in response to the optimal limit output value, wherein the optimal limit output value is a minimum value between the first and second limit output values, and wherein the anticipator is configured to receive the oil pressure value detected by the oil pressure sensor which is installed in an oil main gallery and to delay the received oil pressure value by a predetermined time to predict the oil pressure in the turbocharger. a temperature sensor configured to detect engine-related temperature information; a first calculator configured to calculate a first limit output value of an engine based on the engine-related temperature information inputted from the temperature sensor; an oil pressure sensor configured to detect an oil pressure value of the engine; an anticipator configured to predict an oil pressure in a turbocharger based on the oil pressure value from the oil pressure sensor; a second calculator configured to calculate a second limit output value of the engine based on the predicted oil pressure value in the turbocharger; a determiner configured to determine one of the first and second limit output values inputted from the first and second calculators as an optimal limit output value of the engine; and an engine controller configured to control an output of the engine in response to the optimal limit output value, wherein the optimal limit output value is a minimum value between the first and second limit output values, and
A method for co-cultivating one or more B-cells comprising the steps of - cultivating EL4-B5 cells to a cell density of more than 1,000,000 cells/ml to 1,500,000 cells/ml, and - incubating the one or more B-cells with an aliquot of 10 4 to 10 5 EL4-B5 cells per B-cell of the EL4-B5 cells obtained in the previous step. - cultivating EL4-B5 cells to a cell density of more than 1,000,000 cells/ml to 1,500,000 cells/ml, and - incubating the one or more B-cells with an aliquot of 10 4 to 10 5 EL4-B5 cells per B-cell of the EL4-B5 cells obtained in the previous step.
A L-Carnitine supplement for use in a method of treatment for decreasing skeletal muscle damage during and after intensive physical activity of an active canine, the method comprising administering to the active canine that is undergoing and/or has undergone physical activity that lasts at least 20 minutes and increases a heart rate of the active canine from about 5% to about 150% or more of a resting heart rate of the active canine and wherein the physical activity results in an intensity equivalent of at least 50% of the canine's V0 2 max, an amount of said L-carnitine supplement of from 5 milligrams per kg body weight per day to 25 milligrams per kilogram of body weight per day, wherein the L-Carnitine supplement is administered to the canine in an amount sufficient to inhibit increases in myoglobin amounts in blood after activity such that the myoglobin amounts in blood of the canine receiving the L-carnitine supplement are reduced by greater than 50% in comparison to the same canine that has not received the L-carnitine supplement, and/or such that the mammal has a creatine kinase value after physical activity that is at least 5% less, in comparison to the same mammal that has not received the L-carnitine supplement. an amount of said L-carnitine supplement of from 5 milligrams per kg body weight per day to 25 milligrams per kilogram of body weight per day, wherein the L-Carnitine supplement is administered to the canine in an amount sufficient to inhibit increases in myoglobin amounts in blood after activity such that the myoglobin amounts in blood of the canine receiving the L-carnitine supplement are reduced by greater than 50% in comparison to the same canine that has not received the L-carnitine supplement, and/or such that the mammal has a creatine kinase value after physical activity that is at least 5% less, in comparison to the same mammal that has not received the L-carnitine supplement.
An electromechanical actuator, for moving a first element with respect to a second element, and comprising a movable member provided with connecting means for being attached to said first element, and a frame provided with attaching means for being attached to said second element, wherein said movable member is translationally movable with respect to said frame, said actuator being characterised in that it further comprises at least one mechanical energy absorbing-dissipating structure (28, 30) located on a strain path between said first element and said frame of the actuator and comprising a deformable chamber containing at least one porous capillary matrix having open pores and an associated liquid having a wetting angle higher than 90 degrees relative to said matrix and selected such that at least part of said liquid penetrates the pores of said matrix, when said chamber is subjected to an external mechanical pressure equal to or higher than a first pressure level P1, and is spontaneously rejected off the pores of said matrix by capillary action, when said chamber is subjected to an external mechanical pressure lower than a second pressure level P2 which is lower than said first pressure level P1.
Arrangement for providing broadband accesses for a wide area network, consisting of at least one fixed network access point (1, 1', 1'') interfaced to the wide area network directly in wired fashion on a broadband basis and subscriber-end access technology for using the wide area network by means of at least one computer-based terminal, wherein the subscriber-end access technology comprises at least one antenna having transmission and reception units for the radio-based communication with a fixed network access point (1, 1', 1''), a router device and at least one interface (5, 5') for radio-based and/or wire-based connection of at least the cited computer-based terminal to the router device and is incorporated in the casing (6, 6') of a stationary object or of a mobile object, and wherein the transmission and reception units and also the router device of the subscriber-end access technology are integrated in the frame of a window of the object (7, 7'), and wherein, further, the antenna for the radio-based communication with a fixed network access point (1, 1', 1") a.) is integrated in the frame of this window, which frame is made of a nonconductive material in this case, or b.) is applied to the exterior surface of a windowpane of this or of another window of the object (7, 7'), or c.) is arranged inside the windowpane of this window, which is designed to have multiple glazing, or of another window, which is designed to have multiple glazing, of the object (7, 7'). a.) is integrated in the frame of this window, which frame is made of a nonconductive material in this case, or b.) is applied to the exterior surface of a windowpane of this or of another window of the object (7, 7'), or c.) is arranged inside the windowpane of this window, which is designed to have multiple glazing, or of another window, which is designed to have multiple glazing, of the object (7, 7').
A motion assistance apparatus, comprising: a proximal support configured to support a proximal part of a user; a first drive link (11, 21, 31) and a second drive link (12, 22, 32); a support link (10, 20, 30) comprising a support body (101, 201) and a support joint (102, 302); the support joint (102, 302) being rotatably connected to the second drive link (12, 22, 32); the support body (101, 201) connecting the first drive link (11, 21, 31) and the support joint (102, 302); a distal support connected to the support body (101, 201) configured to support a distal part of a user; and a torque providing device (16a, 16b, 16c, 26, 70) configured to provide a torque to rotate the support joint (102, 302); characterized in that the first drive link (11, 21, 31) is configured to perform a translational motion with respect to the proximal support at a first velocity and the second drive link (12, 22, 32) configured to perform a translational motion with respect to the proximal support at a second velocity, the first velocity being different from the second velocity, such that the support body (101, 201) simultaneously performs a translational motion and a rotational motion with respect to the proximal support, and the support link (10, 20, 30) rotates about a remote center of motion, the RCM being in a vicinity of a joint between the proximal part and distal part of the user when the user wears the motion assistance apparatus. a proximal support configured to support a proximal part of a user; a first drive link (11, 21, 31) and a second drive link (12, 22, 32); a support link (10, 20, 30) comprising a support body (101, 201) and a support joint (102, 302); the support joint (102, 302) being rotatably connected to the second drive link (12, 22, 32); the support body (101, 201) connecting the first drive link (11, 21, 31) and the support joint (102, 302); a distal support connected to the support body (101, 201) configured to support a distal part of a user; and a torque providing device (16a, 16b, 16c, 26, 70) configured to provide a torque to rotate the support joint (102, 302); characterized in that the first drive link (11, 21, 31) is configured to perform a translational motion with respect to the proximal support at a first velocity and the second drive link (12, 22, 32) configured to perform a translational motion with respect to the proximal support at a second velocity, the first velocity being different from the second velocity, such that the support body (101, 201) simultaneously performs a translational motion and a rotational motion with respect to the proximal support, and the support link (10, 20, 30) rotates about a remote center of motion, the RCM being in a vicinity of a joint between the proximal part and distal part of the user when the user wears the motion assistance apparatus.
An inertial angular sensor comprising a support, characterised in that it comprises a resonator, said resonator comprising at least two masses suspended by mechanical springs, a number N of pairs P i (2 ≤ i ≤ N) of electrostatic springs, said resonator defining at least four S 1, S 2, S 3 and S 4 axes of symmetry, characterised in that: - each pair P i consists of two electrostatic springs each having a preferred axis of action D, these electrostatic springs being positioned such that the respective axes D thereof form a right angle, - for at least one spring of any of the pairs and at least one spring of any other pair, the angle formed by these two springs is equal to a predefined angle, said at least two masses being connected to the support by at least some of the N pairs of electrostatic springs and by at least some of the mechanical springs, characterised in that said at least two masses of the resonator comprise an internal mass (3.1) and an external mass (3.2) coupled together by coupling springs, each mass (3.1, 3.2) being connected to the support by mechanical springs, and each mass (3.1, 3.2) being connected to the support by a number N of electrostatic springs. - each pair P i consists of two electrostatic springs each having a preferred axis of action D, these electrostatic springs being positioned such that the respective axes D thereof form a right angle, - for at least one spring of any of the pairs and at least one spring of any other pair, the angle formed by these two springs is equal to a predefined angle,
An image display apparatus configured to be installed on a vehicle having a Z-axis in the forward-backward direction of the vehicle, a Y axis in the up-down direction of the vehicle and an X-axis in the left-right direction of the vehicle, the image display apparatus comprising: an image forming unit (6, 7, 8, 100) configured to form an intermediate image on a surface; and an optical system with a mirror configured to guide the light from the intermediate image to form a virtual image on a transmission and reflection member that is bent; the image display apparatus characterized in that a virtual axis that connects a centre of the intermediate image and the centre of the effective reflection area of the mirror is oblique to the Y-axis, X-axis and Z-axis, so that deformation of the virtual image on the transmission and reflection member is minimised. an image forming unit (6, 7, 8, 100) configured to form an intermediate image on a surface; and an optical system with a mirror configured to guide the light from the intermediate image to form a virtual image on a transmission and reflection member that is bent; the image display apparatus characterized in that a virtual axis that connects a centre of the intermediate image and the centre of the effective reflection area of the mirror is oblique to the Y-axis, X-axis and Z-axis, so that deformation of the virtual image on the transmission and reflection member is minimised.
An in vitro method of identifying compounds that are orthosteric or allosteric ligands of a GPCR and that are capable of binding to an active conformational state of said GPCR, said method comprising the steps of: a) providing a GPCR and a protein binding domain which is capable of specifically binding to a conformational epitope of said GPCR and wherein said protein binding domain comprises a nanobody sequence, or any suitable fragment thereof; b) forming a complex comprising said protein binding domain and said GPCR, in which said GPCR is in an active conformational state; and c) providing a test compound, and d) evaluating whether the test compound binds to the active conformational state of the GPCR; and e) selecting a compound that binds to the active conformational state of the GPCR; in which said protein binding domain and/or said complex is immobilized to a solid support. a) providing a GPCR and a protein binding domain which is capable of specifically binding to a conformational epitope of said GPCR and wherein said protein binding domain comprises a nanobody sequence, or any suitable fragment thereof; b) forming a complex comprising said protein binding domain and said GPCR, in which said GPCR is in an active conformational state; and c) providing a test compound, and d) evaluating whether the test compound binds to the active conformational state of the GPCR; and e) selecting a compound that binds to the active conformational state of the GPCR;
An extrusion press of a metal billet, comprising a die, a punch able to push the billet through the die and a container of the billet upstream of the die, characterized in that it comprises a screw which the punch is integral to, able to engage with a nut screw comprised in the extrusion press, at least one electric motor driving the reciprocal movement of the screw and of the nut screw thus causing the translation of the punch in the extrusion direction.
Apparatus comprising, a radiotherapy delivery apparatus comprising; i. a radiation source adapted to emit a beam of radiation and to rotate around at least one axis that intersects with the beam, the rotation being confined to a limited range of rotation, ii. an associated imaging device, iii. a control means controlling both the source and the imaging device; a treatment planning computer that accepts an image of a patient and parameters defining the machine capabilities, and creates a treatment plan based on both, wherein the source is capable of rotation in that axis through a range of at least x degrees, and a parameter is passed to the treatment planning computer defining the source's available range as x-e where e >0, and the control means is adapted to detect the patient position using the imaging device, determine a rotation r of the patient around the axis relative to the image used by the treatment planning computer, and if r<e compensate for the rotation by offsetting the source by a rotation equal to r. a radiotherapy delivery apparatus comprising; i. a radiation source adapted to emit a beam of radiation and to rotate around at least one axis that intersects with the beam, the rotation being confined to a limited range of rotation, ii. an associated imaging device, iii. a control means controlling both the source and the imaging device; i. a radiation source adapted to emit a beam of radiation and to rotate around at least one axis that intersects with the beam, the rotation being confined to a limited range of rotation, ii. an associated imaging device, iii. a control means controlling both the source and the imaging device; a treatment planning computer that accepts an image of a patient and parameters defining the machine capabilities, and creates a treatment plan based on both, wherein the source is capable of rotation in that axis through a range of at least x degrees, and a parameter is passed to the treatment planning computer defining the source's available range as x-e where e >0, and the control means is adapted to detect the patient position using the imaging device, determine a rotation r of the patient around the axis relative to the image used by the treatment planning computer, and if r<e compensate for the rotation by offsetting the source by a rotation equal to r.
An antisense oligonucleotide of 10-50 nucleotides in length comprising: a sequence that permits specific hybridization to a target region of a human 5'-HT2C receptor (HTR2C) pre-mRNA under stringent conditions, wherein the target region comprises a nucleotide sequence 5' UUGGCCAUAAGAAUUGCAGCGGCUAUGCUCAAUACU 3' (SEQ ID NO:1) and further wherein the stringent conditions comprise 50% formamide with 1 mg heparin at 42°C with hybridization carried out overnight and a wash in 0.2XSSC at 65°C for 15 minutes; or a sequence at least 70% identical to 10 or more contiguous nucleotides that appear in 5' AGUAUUGAGCAUAGCCGCUGCAAUUCUUAUGGCCAA 3' (SEQ ID NO:15), wherein the antisense oligonucleotide is capable of enhancing human 5'HT2C receptor (HTR2C) activity when delivered to a cell. a sequence that permits specific hybridization to a target region of a human 5'-HT2C receptor (HTR2C) pre-mRNA under stringent conditions, wherein the target region comprises a nucleotide sequence 5' UUGGCCAUAAGAAUUGCAGCGGCUAUGCUCAAUACU 3' (SEQ ID NO:1) and further wherein the stringent conditions comprise 50% formamide with 1 mg heparin at 42°C with hybridization carried out overnight and a wash in 0.2XSSC at 65°C for 15 minutes; or a sequence at least 70% identical to 10 or more contiguous nucleotides that appear in 5' AGUAUUGAGCAUAGCCGCUGCAAUUCUUAUGGCCAA 3' (SEQ ID NO:15),
A particle comprising a peripheral opioid receptor antagonist, a first hydrophilic additive that is chitosan, and a second hydrophilic additive that is pentasodium tripolyphosphate; wherein the diameter of the particle is between 30-1000 nm; and wherein the ratio of first hydrophilic additive: second hydrophilic additive: opioid receptor antagonist is between 5:9:4 to 50:9:32 (w/w/w). wherein the diameter of the particle is between 30-1000 nm; and wherein the ratio of first hydrophilic additive: second hydrophilic additive: opioid receptor antagonist is between 5:9:4 to 50:9:32 (w/w/w).