A neuromodulation/evaluation system, comprising: a neuromodulation catheter comprising an elongated shaft defining a lumen therethrough, a proximal portion, and a distal portion, wherein the distal portion is configured to deliver therapeutic neuromodulation at a target site in a renal blood vessel of a human patient; a guidewire configured to be slidably positioned within the lumen of the elongated shaft, the guidewire having a distal portion and a sensing element positioned along the distal portion of the guidewire, wherein the sensing element is configured to detect physiological measurements at the target site; and a controller configured to be communicatively coupled to the sensing element, wherein the controller is further configured to— obtain the physiological measurements via the sensing element; determine a physiological parameter based on the physiological measurements; compare the physiological parameter to a predetermined threshold; and based on the comparison, provide an indication to an operator regarding whether the patient has physiological characteristics indicative of a therapeutic response to renal neuromodulation therapy at the target site; and wherein: the sensing element (105, 114) is configured to detect physiological measurements at a first branch of the renal artery and either at a second branch of the renal artery or at the renal artery; and the controller is configured to— determine a first physiological parameter based on the physiological measurements taken from the first branch, determine a second physiological parameter based either on the physiological measurements taken from the second branch or on the physiological measurements taken from the renal artery, compare the first physiological parameter to the second physiological parameter, and based on the comparison, determine either whether the first or second branch will be more receptive to renal neuromodulation therapy, or whether the first branch or the renal artery will be more receptive to renal neuromodulation therapy. a neuromodulation catheter comprising an elongated shaft defining a lumen therethrough, a proximal portion, and a distal portion, wherein the distal portion is configured to deliver therapeutic neuromodulation at a target site in a renal blood vessel of a human patient; a guidewire configured to be slidably positioned within the lumen of the elongated shaft, the guidewire having a distal portion and a sensing element positioned along the distal portion of the guidewire, wherein the sensing element is configured to detect physiological measurements at the target site; and a controller configured to be communicatively coupled to the sensing element, wherein the controller is further configured to— obtain the physiological measurements via the sensing element; determine a physiological parameter based on the physiological measurements; compare the physiological parameter to a predetermined threshold; and based on the comparison, provide an indication to an operator regarding whether the patient has physiological characteristics indicative of a therapeutic response to renal neuromodulation therapy at the target site; and wherein: the sensing element (105, 114) is configured to detect physiological measurements at a first branch of the renal artery and either at a second branch of the renal artery or at the renal artery; and the controller is configured to— determine a first physiological parameter based on the physiological measurements taken from the first branch, determine a second physiological parameter based either on the physiological measurements taken from the second branch or on the physiological measurements taken from the renal artery, compare the first physiological parameter to the second physiological parameter, and based on the comparison, determine either whether the first or second branch will be more receptive to renal neuromodulation therapy, or whether the first branch or the renal artery will be more receptive to renal neuromodulation therapy. the sensing element (105, 114) is configured to detect physiological measurements at a first branch of the renal artery and either at a second branch of the renal artery or at the renal artery; and the controller is configured to— determine a first physiological parameter based on the physiological measurements taken from the first branch, determine a second physiological parameter based either on the physiological measurements taken from the second branch or on the physiological measurements taken from the renal artery, compare the first physiological parameter to the second physiological parameter, and based on the comparison, determine either whether the first or second branch will be more receptive to renal neuromodulation therapy, or whether the first branch or the renal artery will be more receptive to renal neuromodulation therapy.