A blood flow assist device, comprising: a flexible sleeve with a first portion configured to receive at least a part of an arm of a patient or donor and a second portion configured to engage a portion of a hand of the patient or donor, the flexible sleeve including opposing first and second surfaces configured to be positioned against opposing anterior and posterior surfaces of the arm when said at least a portion of the arm is received within the flexible sleeve; a first plurality of blood flow stimulators incorporated into the first surface of the flexible sleeve and a second plurality of blood flow stimulators incorporated into the second surface of the flexible sleeve; and an actuator assembly coupled to the first and second plurality of blood flow stimulators, wherein the actuator assembly is configured to individually control and selectively actuate each blood flow stimulator to apply a stimulus to the arm to control blood flow through a vein in the arm or hand having a vein access device connected thereto, the first and second portions of the flexible sleeve are configured to position the first and second plurality of blood flow stimulators at a target location of the arm, the flexible sleeve is configured to receive the left arm of a patient or donor to position the first plurality of blood flow stimulators against the anterior surface of the left arm and the second plurality of blood flow stimulators against the posterior surface of the left arm, and the flexible sleeve is configured to receive the right arm of a patient or donor to position the second plurality of blood flow stimulators against the anterior surface of the right arm and the first plurality of blood flow stimulators against the posterior surface of the right arm. a flexible sleeve with a first portion configured to receive at least a part of an arm of a patient or donor and a second portion configured to engage a portion of a hand of the patient or donor, the flexible sleeve including opposing first and second surfaces configured to be positioned against opposing anterior and posterior surfaces of the arm when said at least a portion of the arm is received within the flexible sleeve; a first plurality of blood flow stimulators incorporated into the first surface of the flexible sleeve and a second plurality of blood flow stimulators incorporated into the second surface of the flexible sleeve; and an actuator assembly coupled to the first and second plurality of blood flow stimulators, wherein the actuator assembly is configured to individually control and selectively actuate each blood flow stimulator to apply a stimulus to the arm to control blood flow through a vein in the arm or hand having a vein access device connected thereto, the first and second portions of the flexible sleeve are configured to position the first and second plurality of blood flow stimulators at a target location of the arm, the flexible sleeve is configured to receive the left arm of a patient or donor to position the first plurality of blood flow stimulators against the anterior surface of the left arm and the second plurality of blood flow stimulators against the posterior surface of the left arm, and the flexible sleeve is configured to receive the right arm of a patient or donor to position the second plurality of blood flow stimulators against the anterior surface of the right arm and the first plurality of blood flow stimulators against the posterior surface of the right arm. the actuator assembly is configured to individually control and selectively actuate each blood flow stimulator to apply a stimulus to the arm to control blood flow through a vein in the arm or hand having a vein access device connected thereto, the first and second portions of the flexible sleeve are configured to position the first and second plurality of blood flow stimulators at a target location of the arm, the flexible sleeve is configured to receive the left arm of a patient or donor to position the first plurality of blood flow stimulators against the anterior surface of the left arm and the second plurality of blood flow stimulators against the posterior surface of the left arm, and the flexible sleeve is configured to receive the right arm of a patient or donor to position the second plurality of blood flow stimulators against the anterior surface of the right arm and the first plurality of blood flow stimulators against the posterior surface of the right arm.