A nucleic acid molecule, an expression cassette, or a vector comprising a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence set forth in SEQ ID NO: 1, 4, 7, 10, 19, 22, 25, or 34; (b) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 2, 5, 8, 11, 20, 23, 26, or 35; (c) the nucleotide sequence set forth in SEQ ID NO: 3, 6, 9, 12, 21, 24, 27, or 36; (d) a nucleotide sequence having at least 85% sequence identity to at least one of the nucleotide sequences set forth in (a), or a nucleotide sequence having at least 97% sequence identity to at least one of the nucleotide sequences set forth in (c), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; and (e) a nucleotide sequence encoding an amino acid sequence having at least 97% sequence identity to at least one amino acid sequence set forth in (b), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; (f) a nucleotide sequence, having at least 85% sequence identity to at least one of the nucleotide sequences set forth in (a) or (c), or encoding an amino acid sequence having at least 85% sequence identity to at least one amino acid sequence set forth in (b), wherein the nucleotide sequence encodes a protein comprising a leucine-rich repeat domain which comprises an amino acid selected from the group consisting of serine at the amino acid position corresponding to amino acid 607 of SEQ ID NO: 2, tyrosine at the amino acid position corresponding to amino acid 650, of SEQ ID NO: 2, serine at the amino acid position corresponding to amino acid 651 of SEQ ID NO: 2, and glycine at the amino acid position corresponding to amino acid 657 of SEQ ID NO: 2, and wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; (g) the nucleotide sequence set forth in SEQ ID NO: 49; (h) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 50; (i) the nucleotide sequence set forth in SEQ ID NO: 51; (j) a nucleotide sequence having at least 85% sequence identity to the nucleotide sequence set forth in (g), or a nucleotide sequence having at least 93% sequence identity to the nucleotide sequence set forth in (i), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; and (k) a nucleotide sequence encoding an amino acid sequence having at least 93% sequence identity to the amino acid sequence set forth in (h), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule. (a) the nucleotide sequence set forth in SEQ ID NO: 1, 4, 7, 10, 19, 22, 25, or 34; (b) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 2, 5, 8, 11, 20, 23, 26, or 35; (c) the nucleotide sequence set forth in SEQ ID NO: 3, 6, 9, 12, 21, 24, 27, or 36; (d) a nucleotide sequence having at least 85% sequence identity to at least one of the nucleotide sequences set forth in (a), or a nucleotide sequence having at least 97% sequence identity to at least one of the nucleotide sequences set forth in (c), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; and (e) a nucleotide sequence encoding an amino acid sequence having at least 97% sequence identity to at least one amino acid sequence set forth in (b), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; (f) a nucleotide sequence, having at least 85% sequence identity to at least one of the nucleotide sequences set forth in (a) or (c), or encoding an amino acid sequence having at least 85% sequence identity to at least one amino acid sequence set forth in (b), wherein the nucleotide sequence encodes a protein comprising a leucine-rich repeat domain which comprises an amino acid selected from the group consisting of serine at the amino acid position corresponding to amino acid 607 of SEQ ID NO: 2, tyrosine at the amino acid position corresponding to amino acid 650, of SEQ ID NO: 2, serine at the amino acid position corresponding to amino acid 651 of SEQ ID NO: 2, and glycine at the amino acid position corresponding to amino acid 657 of SEQ ID NO: 2, and wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; (g) the nucleotide sequence set forth in SEQ ID NO: 49; (h) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 50; (i) the nucleotide sequence set forth in SEQ ID NO: 51; (j) a nucleotide sequence having at least 85% sequence identity to the nucleotide sequence set forth in (g), or a nucleotide sequence having at least 93% sequence identity to the nucleotide sequence set forth in (i), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule; and (k) a nucleotide sequence encoding an amino acid sequence having at least 93% sequence identity to the amino acid sequence set forth in (h), wherein the nucleic acid molecule is capable of conferring resistance to stem rust to a wheat plant comprising the nucleic acid molecule.