A surgical instrument including an electric motor, said surgical instrument comprising: a housing; an elongate shaft extending from said housing, wherein said elongate shaft comprises a rotary drive member configured to rotate in response to rotary motion from the electric motor; an elongate channel comprising a proximal end and a distal end; a drive screw operably engaged with said rotary drive member, wherein said drive screw is configured to rotate in response to the rotation of said rotary drive member, and wherein said drive screw is rotatably attached to said elongate channel at said distal end of said elongate channel, wherein the drive screw comprises a threaded central portion; a firing member operably engaged with said drive screw comprising a threaded drive nut portion configured to be threadedly engaged with the threaded central portion of the drive screw, wherein said firing member is movable from a proximal position toward a distal position when said drive screw is rotated in a first direction, and wherein said firing member is movable from said distal position toward said proximal position when said drive screw is rotated in a second direction opposite said first direction; and a staple cartridge removably retained within said elongate channel, comprising: a cartridge body removable from over said drive screw; staples removably stored in said cartridge body; and a sled configured to deploy said staples from said cartridge body and further configured to be driven distally through the surgical staple cartridge as the firing member is driven distally therethrough, wherein said sled is removable with said cartridge body, wherein at least a portion of said sled is positioned lateral to said drive screw when said staple cartridge is seated in said elongate channel, and wherein said staple cartridge is replaceable with another staple cartridge. a housing; an elongate shaft extending from said housing, wherein said elongate shaft comprises a rotary drive member configured to rotate in response to rotary motion from the electric motor; an elongate channel comprising a proximal end and a distal end; a drive screw operably engaged with said rotary drive member, wherein said drive screw is configured to rotate in response to the rotation of said rotary drive member, and wherein said drive screw is rotatably attached to said elongate channel at said distal end of said elongate channel, wherein the drive screw comprises a threaded central portion; a firing member operably engaged with said drive screw comprising a threaded drive nut portion configured to be threadedly engaged with the threaded central portion of the drive screw, wherein said firing member is movable from a proximal position toward a distal position when said drive screw is rotated in a first direction, and wherein said firing member is movable from said distal position toward said proximal position when said drive screw is rotated in a second direction opposite said first direction; and a staple cartridge removably retained within said elongate channel, comprising: a cartridge body removable from over said drive screw; staples removably stored in said cartridge body; and a sled configured to deploy said staples from said cartridge body and further configured to be driven distally through the surgical staple cartridge as the firing member is driven distally therethrough, wherein said sled is removable with said cartridge body, wherein at least a portion of said sled is positioned lateral to said drive screw when said staple cartridge is seated in said elongate channel, and wherein said staple cartridge is replaceable with another staple cartridge. a cartridge body removable from over said drive screw; staples removably stored in said cartridge body; and a sled configured to deploy said staples from said cartridge body and further configured to be driven distally through the surgical staple cartridge as the firing member is driven distally therethrough, wherein said sled is removable with said cartridge body, wherein at least a portion of said sled is positioned lateral to said drive screw when said staple cartridge is seated in said elongate channel, and wherein said staple cartridge is replaceable with another staple cartridge.