An interbody spinal implant (1, 101, 101a, 201, 301) comprising: a body having a top surface (10, 110, 110a, 210, 310), a bottom surface (20, 120, 120a, 220, 320), opposing lateral sides (30, 130, 130a, 230, 330), opposing anterior (40, 140, 140a, 240, 340) and posterior (50, 150, 150a, 250, 350) portions, a substantially hollow center, and a single vertical aperture (60, 160, 160a, 260, 360); an integration surface on the top surface (10, 110, 110a, 210, 310) and on the bottom surface (20, 120, 120a, 220, 320), said integration surface having a roughened surface topography (80, 180, 180a, 280, 380) including macro features, micro features, and nano features, without sharp teeth that risk damage to bone structures, adapted to be in contact with adjacent vertebral endplates; at least one graft contact surface having a coarse surface topography including micro features and nano features adapted to be in contact with a bone growth inducing material; and at least one soft tissue surface having a substantially smooth surface including nano features adapted to be in contact with bone or soft tissue during or after implantation; characterized in that the macro features have a mean spacing between about 400-2,000 microns, a maximum peak-to-valley height between about 40-500 microns, and an average amplitude between about 20-200 microns; the micro features have a mean spacing between about 20-400 microns, a maximum peak-to-valley height between about 2-40 microns, and an average amplitude between about 1-20 microns; and the nano features have a mean spacing between about 0.5-20 microns, a maximum peak-to-valley height between about 0.2-2 microns, and an average amplitude between about 0.01-1 microns. a body having a top surface (10, 110, 110a, 210, 310), a bottom surface (20, 120, 120a, 220, 320), opposing lateral sides (30, 130, 130a, 230, 330), opposing anterior (40, 140, 140a, 240, 340) and posterior (50, 150, 150a, 250, 350) portions, a substantially hollow center, and a single vertical aperture (60, 160, 160a, 260, 360); an integration surface on the top surface (10, 110, 110a, 210, 310) and on the bottom surface (20, 120, 120a, 220, 320), said integration surface having a roughened surface topography (80, 180, 180a, 280, 380) including macro features, micro features, and nano features, without sharp teeth that risk damage to bone structures, adapted to be in contact with adjacent vertebral endplates; at least one graft contact surface having a coarse surface topography including micro features and nano features adapted to be in contact with a bone growth inducing material; and at least one soft tissue surface having a substantially smooth surface including nano features adapted to be in contact with bone or soft tissue during or after implantation; characterized in that the macro features have a mean spacing between about 400-2,000 microns, a maximum peak-to-valley height between about 40-500 microns, and an average amplitude between about 20-200 microns; the micro features have a mean spacing between about 20-400 microns, a maximum peak-to-valley height between about 2-40 microns, and an average amplitude between about 1-20 microns; and the nano features have a mean spacing between about 0.5-20 microns, a maximum peak-to-valley height between about 0.2-2 microns, and an average amplitude between about 0.01-1 microns.