mhurhangee/ep-ind-claims huggingface dataset:
A method for inserting an exogenous sequence into an amplifiable locus of a mammalian cell comprising: (a) providing a mammalian cell having an endogenous target site proximal to an endogenous selectable gene within the amplifiable locus, wherein the endogenous target site is 0 to 100,000 base pairs downstream from the 3' regulatory region of the endogenous selectable gene or 0 to 100,000 base pairs upstream from the 5' regulatory region of the endogenous selectable gene, wherein the endogenous target site comprises: (i) a recognition sequence for an engineered meganuclease; (ii) a 5' flanking region 5' to the recognition sequence; and (iii) a 3' flanking region 3' to the recognition sequence; and (b) introducing a double-stranded break between the 5' and 3' flanking regions of the endogenous target site; (c) contacting the cell with a donor vector comprising from 5' to 3': (i) a donor 5' flanking region homologous to the 5' flanking region of the endogenous target site; (ii) an exogenous sequence; and (iii) a donor 3' flanking region homologous to the 3' flanking region of the endogenous target site; whereby the donor 5' flanking region, the exogenous sequence and the donor 3' flanking region are inserted between the 5' and 3' flanking regions of the endogenous target site by homologous recombination to provide a modified cell. (a) providing a mammalian cell having an endogenous target site proximal to an endogenous selectable gene within the amplifiable locus, wherein the endogenous target site is 0 to 100,000 base pairs downstream from the 3' regulatory region of the endogenous selectable gene or 0 to 100,000 base pairs upstream from the 5' regulatory region of the endogenous selectable gene, wherein the endogenous target site comprises: (i) a recognition sequence for an engineered meganuclease; (ii) a 5' flanking region 5' to the recognition sequence; and (iii) a 3' flanking region 3' to the recognition sequence; and (i) a recognition sequence for an engineered meganuclease; (ii) a 5' flanking region 5' to the recognition sequence; and (iii) a 3' flanking region 3' to the recognition sequence; and (b) introducing a double-stranded break between the 5' and 3' flanking regions of the endogenous target site; (c) contacting the cell with a donor vector comprising from 5' to 3': (i) a donor 5' flanking region homologous to the 5' flanking region of the endogenous target site; (ii) an exogenous sequence; and (iii) a donor 3' flanking region homologous to the 3' flanking region of the endogenous target site; (i) a donor 5' flanking region homologous to the 5' flanking region of the endogenous target site; (ii) an exogenous sequence; and (iii) a donor 3' flanking region homologous to the 3' flanking region of the endogenous target site;
A method for determining a position of a user equipment, UE, performed by the UE, the method comprising: receiving from a serving gNB assistance data for a plurality of gNBs, which includes the serving gNB, wherein the assistance data comprises the location of each gNB of the plurality of gNBs; transmitting to the plurality of gNBs uplink reference signals; receiving from the serving gNB uplink reference signal measurements measured by each of the plurality of gNBs, wherein the received uplink reference signal measurements are time-of-arrival, TOA, measurements; determining the position of the UE based on the uplink reference signal measurements measured by each of the plurality of gNBs and the assistance data for the plurality of the gNBs. receiving from a serving gNB assistance data for a plurality of gNBs, which includes the serving gNB, wherein the assistance data comprises the location of each gNB of the plurality of gNBs; transmitting to the plurality of gNBs uplink reference signals; receiving from the serving gNB uplink reference signal measurements measured by each of the plurality of gNBs, wherein the received uplink reference signal measurements are time-of-arrival, TOA, measurements; determining the position of the UE based on the uplink reference signal measurements measured by each of the plurality of gNBs and the assistance data for the plurality of the gNBs.
Fluid consumption meter arranged to measure a flow rate of a fluid and comprising a control device with a sound detection module arranged to detect a sound in said fluid characterized in that the control device is configured such that said at least one further module (20, 22, 24) of the fluid consumption meter not required for sound detection is deactivated prior to starting a sound detection and during activation of the sound detection module the least one further module (20, 22, 24) of the consumption meter not required for sound detection is in a deactivated state to avoid or reduce a disturbance occurring from the operation of this further module.
Saddle for bicycles or motorcycles, comprising a support body having a front portion and a rear portion, a pair of pins spaced apart from one another, said pins projecting downwards from the bottom of said support body at said rear portion, a saddle rail for connecting said saddle to a support frame, said saddle rail comprising a pair of arms (8, 9) that project towards said rear portion each provided with an end portion, an interchangeable damping system, first connection means, of the removable type, for connecting said saddle rail to said front portion, second connection means, of the removable type, for connecting each of said arms (8, 9) to said rear portion, at said pair of pins, and at least one elastic element mounted along at least one of said pins and, in use, arranged between said support body and said second connection means, said second connection means being suitable for compressing said at least one elastic element and comprise a pair of bushes and a pair of respective adjustment ring nuts, each of which can be slidingly engaged along a respective one of said pins, each of said adjustment ring nuts, in use, being arranged between one of said bushes and at least one respective elastic element to compress said at least one elastic element, characterised in that each of said adjustment ring nuts has, at the top, a substantially flat surface, in use, in abutment against a respective of said at least one elastic element and, at the bottom, a plurality of elements in relief, projecting from said adjustment ring nut, operatively engaged with a respective one of said bushes, wherein each of said bushes has, at a portion that is upper when in use, a shaped circumferential seat, comprising a plurality of spaces alternated with a plurality of crests, for housing, in use, said elements in relief, and wherein said spaces have different depths suitable for determining respective predefined relative distances between said bush and said adjustment ring nut.
A rolling bearing assembly comprising: a radially inner ring defining an inner race and including a first circumferentially extending seal groove; a radially outer ring defining an outer race, and including a second circumferentially extending seal groove; rolling elements supported between the radially inner ring and the radially outer ring, the rolling elements running on the inner race and the outer race; and at least one seal including a radially outer end engaged within the second circumferentially extending seal groove, and a radially inner end located in the first circumferentially extending seal groove, characterized in that the second circumferentially extending seal groove has a pressure groove therein, located inside of an axial end face of the at least one seal, and at least one hydraulic fluid gallery including an inlet and an outlet connected to the pressure groove; wherein in a first non-pressurized operating condition, the radially inner end of the at least one seal is configured to contact the first circumferentially extending seal groove on the radially inner ring, and in a second operating condition, in which the at least one hydraulic fluid gallery is supplied with pressurized hydraulic fluid, the at least one seal is configured to be moved outwardly in an axial direction such that the radially inner end of the at least one seal disengages from the radially inner ring. a radially inner ring defining an inner race and including a first circumferentially extending seal groove; a radially outer ring defining an outer race, and including a second circumferentially extending seal groove; rolling elements supported between the radially inner ring and the radially outer ring, the rolling elements running on the inner race and the outer race; and at least one seal including a radially outer end engaged within the second circumferentially extending seal groove, and a radially inner end located in the first circumferentially extending seal groove, characterized in that the second circumferentially extending seal groove has a pressure groove therein, located inside of an axial end face of the at least one seal, and at least one hydraulic fluid gallery including an inlet and an outlet connected to the pressure groove; wherein in a first non-pressurized operating condition, the radially inner end of the at least one seal is configured to contact the first circumferentially extending seal groove on the radially inner ring, and in a second operating condition, in which the at least one hydraulic fluid gallery is supplied with pressurized hydraulic fluid, the at least one seal is configured to be moved outwardly in an axial direction such that the radially inner end of the at least one seal disengages from the radially inner ring.
Motor vehicle windscreen wiper fluid distribution device, comprising a windscreen washer fluid distribution network having: - at least one hydraulic duct (7, 8) comprising at least one windscreen washer fluid circulation channel, - at least one hydraulic coupling (9, 10, 11, 15) coupled to the circulation channel, said distribution device further comprising at least one heat-conducting member (16; 22; 31; 33; 39), in thermal contact on one side with at least one hydraulic coupling (9, 10, 11, 15), and on the other side with a heating element (5, 6, 21) of the distribution device, said heat-conducting member (16; 22; 31; 33; 39) comprising a retaining means specifically for securing said heat-conducting member (16; 22; 31; 33; 39) to the windscreen washer fluid distribution network, and being in contact with two opposite faces of the hydraulic coupling, the distribution device is characterized in that said heat-conducting member (16; 22; 31; 33; 39) is removable and in that the retaining means comprises at least one pair of elastic tabs (27, 28) forming a clamp cooperating with at least one hydraulic coupling. - at least one hydraulic duct (7, 8) comprising at least one windscreen washer fluid circulation channel, - at least one hydraulic coupling (9, 10, 11, 15) coupled to the circulation channel, said distribution device further comprising at least one heat-conducting member (16; 22; 31; 33; 39), in thermal contact on one side with at least one hydraulic coupling (9, 10, 11, 15), and on the other side with a heating element (5, 6, 21) of the distribution device, said heat-conducting member (16; 22; 31; 33; 39) comprising a retaining means specifically for securing said heat-conducting member (16; 22; 31; 33; 39) to the windscreen washer fluid distribution network, and being in contact with two opposite faces of the hydraulic coupling, the distribution device is characterized in that said heat-conducting member (16; 22; 31; 33; 39) is removable and in that the retaining means comprises at least one pair of elastic tabs (27, 28) forming a clamp cooperating with at least one hydraulic coupling.
A composition comprising a therapeutically effective amount of apilimod, or a pharmaceutically acceptable salt thereof for use in a method of treating renal cancer in a subject having renal cancer, wherein the method further comprises administering at least one additional therapeutic agent.
A kit for hair dyeing or bleaching comprising: a first part comprising an alkali agent, a second part comprising an oxidizing agent, a thickening composition comprising a thickening agent, and an openable and closable airtight container, wherein the first and second parts and the thickening composition are charged into the container and a mixture thereof is shaken to form foam of the mixture, wherein any one or more of the first part, the second part, and the thickening composition comprise a surfactant, and wherein the inner circumference of the opening of the main body of the container is 25 to 35 cm. a first part comprising an alkali agent, a second part comprising an oxidizing agent, a thickening composition comprising a thickening agent, and an openable and closable airtight container, wherein the first and second parts and the thickening composition are charged into the container and a mixture thereof is shaken to form foam of the mixture, wherein any one or more of the first part, the second part, and the thickening composition comprise a surfactant, and wherein the inner circumference of the opening of the main body of the container is 25 to 35 cm.
An apparatus comprising: at least one interface configured to be coupled to a storage device; and at least one processing device configured to: detect the storage device; perform a check-in process so that the storage device is recognizable by one or more protected nodes (102, 102a-102n) within a protected system and not recognizable by nodes outside of the protected system while the storage device is checked-in; and store data associated with one or more cyber-security threats on the storage device; detect the storage device a second time; wherein the apparatus is characterised by the at least one processing device being further configured to: retrieve audit data on the storage device, the audit data identifying which of the one or more protected nodes (102, 102a-102n) accessed the data associated with the one or more cyber-security threats on the storage device; and perform a check-out process so that the storage device is recognizable by the nodes outside of the protected system and not recognizable by the one or more protected nodes (102, 102a-102n) within the protected system while the storage device is checked-out. at least one interface configured to be coupled to a storage device; and at least one processing device configured to: detect the storage device; perform a check-in process so that the storage device is recognizable by one or more protected nodes (102, 102a-102n) within a protected system and not recognizable by nodes outside of the protected system while the storage device is checked-in; and store data associated with one or more cyber-security threats on the storage device; detect the storage device; perform a check-in process so that the storage device is recognizable by one or more protected nodes (102, 102a-102n) within a protected system and not recognizable by nodes outside of the protected system while the storage device is checked-in; and store data associated with one or more cyber-security threats on the storage device; detect the storage device a second time; wherein the apparatus is characterised by the at least one processing device being further configured to: retrieve audit data on the storage device, the audit data identifying which of the one or more protected nodes (102, 102a-102n) accessed the data associated with the one or more cyber-security threats on the storage device; and perform a check-out process so that the storage device is recognizable by the nodes outside of the protected system and not recognizable by the one or more protected nodes (102, 102a-102n) within the protected system while the storage device is checked-out. retrieve audit data on the storage device, the audit data identifying which of the one or more protected nodes (102, 102a-102n) accessed the data associated with the one or more cyber-security threats on the storage device; and perform a check-out process so that the storage device is recognizable by the nodes outside of the protected system and not recognizable by the one or more protected nodes (102, 102a-102n) within the protected system while the storage device is checked-out.
Tool device with a tool, a drive for driving the tool, a device housing, a structural unit additional to the device housing and integral with the housing, a shaft connected with the drive and mounted in the structural unit that is integral with the housing, a brake (22a, 22b) designed as a friction brake with a friction element that is integral with the housing for braking the tool, a mechanical control unit for controlling the brake (22a, 22b) that uses the drive torque as input variable and that is prepared to mechanically convert the drive torque into a force releasing the brake (22a, 22b) and a spring means that is prepared to push the brake (22a, 22b) into a braking condition when the drive torque drops under a brake threshold value, wherein the brake threshold value exists for a positive driving torque and the friction element is mounted on the structural unit that is integral with the housing as well as on the shaft.
A computer-implemented method for predicting a clinical outcome related to a patient suffering from colorectal cancer comprising: (a) determining a predictor value algorithmically using patient sample values for at least one marker selected from the group consisting of tumor markers, immune markers, acute phase markers, and at least one marker that is (i) selected from the group consisting of an extracellular matrix marker, a marker that is indicative of extracellular matrix synthesis (fibrogenesis), and a marker that is indicative of extracellular matrix degradation (fibrolysis), and (b) predicting the clinical outcome of the colorectal cancer by evaluating the predictor value wherein the marker of and the marker of are not the same, wherein the predictor value is determined using an algorithm derived by Cox Regression Analysis and is used to assess the probability that the patient will respond favorably to an antineoplastic treatment regimen.
A process for producing a gas diffusion electrode comprising the steps of: casting a porous electrically conductive web with a suspension of particles of an electrically conductive material in a solution of a first binder to provide a first layer which is an electrochemically active layer; casting a suspension of particles of a hydrophobic material in a solution of a second binder on said first layer to provide a second layer; and subjecting said first and second layer to phase inversion thereby realising porosity in both said first layer and said second layer, wherein said subjection of said second layer to phase inversion thereby realises a water repellent layer, wherein said hydrophobic material is a fluorinated polymer or an electrically non-conductive mineral.
A sensor-driven glucose control system, comprising: a glucose sensor operative to continually measure glucose level of a subject and generate a corresponding glucose level signal; an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and a controller operative to generate the insulin dose control signal in response to the glucose level signal by: modulating a basal infusion rate of insulin about a nominal basal infusion rate in response to short-term variations of glucose level occurring on the order of seconds to minutes; and continually adjusting the nominal basal infusion rate such that the nominal basal infusion rate is dependent on a moving average, over a time interval that is on the order of hours, of the basal infusion rate as modulated, the nominal basal infusion rate being adjusted over a longer term than a short term on which the basal infusion rate is modulated, wherein modulating the basal infusion rate of insulin is constrained to fall within minimum and maximum values around the nominal basal infusion rate. a glucose sensor operative to continually measure glucose level of a subject and generate a corresponding glucose level signal; an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and a controller operative to generate the insulin dose control signal in response to the glucose level signal by: modulating a basal infusion rate of insulin about a nominal basal infusion rate in response to short-term variations of glucose level occurring on the order of seconds to minutes; and continually adjusting the nominal basal infusion rate such that the nominal basal infusion rate is dependent on a moving average, over a time interval that is on the order of hours, of the basal infusion rate as modulated, the nominal basal infusion rate being adjusted over a longer term than a short term on which the basal infusion rate is modulated, wherein modulating the basal infusion rate of insulin is constrained to fall within minimum and maximum values around the nominal basal infusion rate. modulating a basal infusion rate of insulin about a nominal basal infusion rate in response to short-term variations of glucose level occurring on the order of seconds to minutes; and continually adjusting the nominal basal infusion rate such that the nominal basal infusion rate is dependent on a moving average, over a time interval that is on the order of hours, of the basal infusion rate as modulated, the nominal basal infusion rate being adjusted over a longer term than a short term on which the basal infusion rate is modulated, wherein modulating the basal infusion rate of insulin is constrained to fall within minimum and maximum values around the nominal basal infusion rate.
A method of operating a terminal device in a first network that is operating according to a first radio access technology, RAT, the terminal device supporting and operating according to a network interworking feature that enables and controls interworking between the first network and a network operating according to a second RAT, the method comprising: determining whether a first cell in the first network that is serving the terminal device supports the network interworking feature; and characterized by: modifying the operation of the terminal device with respect to the network interworking feature if it is determined that the first cell does not support the network interworking feature, wherein the step of modifying the operation of the terminal device comprises the terminal device: disabling the network interworking feature or ceasing to act according to the network interworking feature; and refraining from connecting to WLANs indicated to the terminal device by the first network, wherein the first RAT is a 3GPP RAT, the second RAT is a WLAN RAT, and the networking interworking feature is a 3GPP/WLAN interworking feature. disabling the network interworking feature or ceasing to act according to the network interworking feature; and refraining from connecting to WLANs indicated to the terminal device by the first network, wherein the first RAT is a 3GPP RAT, the second RAT is a WLAN RAT, and the networking interworking feature is a 3GPP/WLAN interworking feature.
A dual transistor RF power amplifier, said transistors (Q1, Q2) being push-pull controlled field effect transistors, said transistors being configured to operate asymmetrically, meaning that the drain-source currents (IDS1, IDS2) of said transistors in the on state are different, said currents being controlled by the gate voltages (V G1, V G2) of said transistors (Q1, Q2), characterised in that said currents are independently controlled by a control stage and the values of said voltages are based on operating parameters, said amplifier comprising a memory storing the pairs of said values based on said parameters, the memory being accessible to said control stage.