Manifold for water dispensing units, comprising a manifold body in which the following is identified: - one or more inlet paths (3, 4) configured to be connected to a water supply network; - at least one outlet path configured to be connected to dispensing means of said dispensing unit; - a collecting chamber defining a longitudinal axis, delimited by a lateral wall and communicating with said inlet paths (3, 4) and with said outlet path, said collecting chamber being configured to receive the insertion of a cartridge body for the regulation of flow through said inlet paths (3, 4) and output path and in which a mixing chamber is present, provided with inlet mouths (10, 11) configured to communicate with said inlet paths (3, 4) and at least one outlet mouth configured to communicate with said outlet path; - a safety group associated with said manifold body and comprising: • a flange removably attached to said manifold body; • a safety shutter provided with through inlet gaps (15, 16) and with shut-off surfaces (17, 18) adapted to alternately cooperate with said inlet paths (3, 4); • a control body for the movement of said safety shutter from at least a first position, in which said through inlet gaps (15, 16) of said safety shutter communicate with said inlet paths (3, 4), to at least a second position in which said shut-off surfaces (17, 18) of said safety shutter sealingly close said inlet paths (3, 4), and vice versa, characterized in that it further comprises: - contrast means cooperating with one or more shaped elements belonging to the control body to prevent the separation of said control body and said cartridge body from said manifold body when said safety shutter is arranged in said first position; - sliding means cooperating with said shaped elements to allow the separation of said control body and said cartridge body from said manifold body for moving both along said flange in said longitudinal direction when said safety shutter is arranged in said second position, wherein said sliding means comprise at least one longitudinal groove which develops parallel to said axis internally to said flange and said contrast means comprise at least one annular groove formed peripherally inside said flange, said grooves (23a, 24a) having one or more intersection areas. - one or more inlet paths (3, 4) configured to be connected to a water supply network; - at least one outlet path configured to be connected to dispensing means of said dispensing unit; - a collecting chamber defining a longitudinal axis, delimited by a lateral wall and communicating with said inlet paths (3, 4) and with said outlet path, said collecting chamber being configured to receive the insertion of a cartridge body for the regulation of flow through said inlet paths (3, 4) and output path and in which a mixing chamber is present, provided with inlet mouths (10, 11) configured to communicate with said inlet paths (3, 4) and at least one outlet mouth configured to communicate with said outlet path; - a safety group associated with said manifold body and comprising: • a flange removably attached to said manifold body; • a safety shutter provided with through inlet gaps (15, 16) and with shut-off surfaces (17, 18) adapted to alternately cooperate with said inlet paths (3, 4); • a control body for the movement of said safety shutter from at least a first position, in which said through inlet gaps (15, 16) of said safety shutter communicate with said inlet paths (3, 4), to at least a second position in which said shut-off surfaces (17, 18) of said safety shutter sealingly close said inlet paths (3, 4), and vice versa, • a flange removably attached to said manifold body; • a safety shutter provided with through inlet gaps (15, 16) and with shut-off surfaces (17, 18) adapted to alternately cooperate with said inlet paths (3, 4); • a control body for the movement of said safety shutter from at least a first position, in which said through inlet gaps (15, 16) of said safety shutter communicate with said inlet paths (3, 4), to at least a second position in which said shut-off surfaces (17, 18) of said safety shutter sealingly close said inlet paths (3, 4), and vice versa, - contrast means cooperating with one or more shaped elements belonging to the control body to prevent the separation of said control body and said cartridge body from said manifold body when said safety shutter is arranged in said first position; - sliding means cooperating with said shaped elements to allow the separation of said control body and said cartridge body from said manifold body for moving both along said flange in said longitudinal direction when said safety shutter is arranged in said second position,