A system comprising: a sample cartridge (100, 1100) configured to hold an unprepared sample, the sample cartridge (100, 1100) comprising a plurality of processing chambers fluidically interconnected by a moveable valve body; a module configured for performing sample preparation of the sample while disposed within the cartridge, the module having a cartridge receiver adapted to receive and removably couple with the sample cartridge (100, 1100) to perform sample preparation and an instrument interface (300, 1300); and a chip carrier device (200, 1200) having a fluidic interface (211, 1211) configured for fluidically coupling with the sample cartridge (100, 1100), the fluidic interface (211, 1211) being in fluid communication with a flowcell chamber (224, 1224) of the device in communication with a chip when carried within a chip carrier portion of the device, wherein the flowcell chamber is adapted to interface with an active area of the chip when carried within the chip carrier portion of the device, wherein the chip carrier portion is configured for supporting a no-leads chip, wherein the chip is configured for performing processing or analysis of the sample when carried within the chip carrier portion of the device, wherein the chip carrier device includes an electrical interface, the electrical interface configured for powering the no-leads chip, when supported within the carrier portion of the device when operably coupled to the sample cartridge (100, 1100), wherein the electrical interface includes a plurality of contacts arranged so as to electrically couple with electrical contacts of the instrument interface (300, 1300). a sample cartridge (100, 1100) configured to hold an unprepared sample, the sample cartridge (100, 1100) comprising a plurality of processing chambers fluidically interconnected by a moveable valve body; a module configured for performing sample preparation of the sample while disposed within the cartridge, the module having a cartridge receiver adapted to receive and removably couple with the sample cartridge (100, 1100) to perform sample preparation and an instrument interface (300, 1300); and a chip carrier device (200, 1200) having a fluidic interface (211, 1211) configured for fluidically coupling with the sample cartridge (100, 1100), the fluidic interface (211, 1211) being in fluid communication with a flowcell chamber (224, 1224) of the device in communication with a chip when carried within a chip carrier portion of the device, wherein the flowcell chamber is adapted to interface with an active area of the chip when carried within the chip carrier portion of the device, wherein the chip carrier portion is configured for supporting a no-leads chip, wherein the chip is configured for performing processing or analysis of the sample when carried within the chip carrier portion of the device, wherein the chip carrier device includes an electrical interface, the electrical interface configured for powering the no-leads chip, when supported within the carrier portion of the device when operably coupled to the sample cartridge (100, 1100), wherein the electrical interface includes a plurality of contacts arranged so as to electrically couple with electrical contacts of the instrument interface (300, 1300).