An occlusion catheter system for occlusion of a relatively large vessel, the occlusion catheter system comprising: a proximal hub (190, 590) having an inflation connection port and an inflation pathway (194, 594) defined in the connection port; an inflation catheter member (110,_510) connected to the proximal hub, the inflation catheter member (110, 510) having an inflation lumen (210, 610) and a first port (160, 560, 1709b) proximate a distal end of the inflation catheter member (110, 510), the inflation catheter member (110, 510) defining a longitudinal axis (131, 531, 1707, 1707'); an occlusion balloon (140, 540, 1708) having a proximal balloon end and a distal balloon end (146, 546, 1708b), the proximal balloon end connected proximate to the distal end of the inflation catheter (110, 510); the first port (160, 560, 1709b) opening into an internal space (142, 542) of the occlusion balloon (140, 540, 1708); a distal catheter member (120, 520, 1705, 1705') positioned substantially on the longitudinal axis (131, 531, 1707) and connected to the distal balloon end (546, 1708b); and a guide wire, characterized in that an atraumatic tip (150, 550, 1706, 1706') on a distal end of the distal catheter member (120, 520, 1705, 1705'), the atraumatic tip (150, 550, 1706, 1706') having a substantially circular profile in a relaxed configuration with an unconnected end positioned proximate the longitudinal axis (131, 531, 1707, 1707'), the atraumatic tip (150, 550, 1706, 1706') being substantially solid along the circular profile, the atraumatic tip (150, 550, 1706, 1706') including a tip shaft (1705, 1705') with a guide lumen (1703, 1703') therein and having a substantially flattened cylindrical shape with an inner planar surface (455, 555, 1709, 1709'), an outer planar surface (457, 557) and opposing surfaces (458, 459, 558, 559), the guide lumen (1703, 1703') including an exit port (1702, 1702') proximate the distal end of the atraumatic tip (550, 1706, 1706') positioned proximate the longitudinal axis (131, 531, 1707, 1707'), the guide wire configured for slidable movement within the guide lumen (1703, 1703') and extendable out of the exit port (1702, 1702') beyond the atraumatic tip (150, 550, 1706, 1706'). a proximal hub (190, 590) having an inflation connection port and an inflation pathway (194, 594) defined in the connection port; an inflation catheter member (110,_510) connected to the proximal hub, the inflation catheter member (110, 510) having an inflation lumen (210, 610) and a first port (160, 560, 1709b) proximate a distal end of the inflation catheter member (110, 510), the inflation catheter member (110, 510) defining a longitudinal axis (131, 531, 1707, 1707'); an occlusion balloon (140, 540, 1708) having a proximal balloon end and a distal balloon end (146, 546, 1708b), the proximal balloon end connected proximate to the distal end of the inflation catheter (110, 510); the first port (160, 560, 1709b) opening into an internal space (142, 542) of the occlusion balloon (140, 540, 1708); a distal catheter member (120, 520, 1705, 1705') positioned substantially on the longitudinal axis (131, 531, 1707) and connected to the distal balloon end (546, 1708b); and a guide wire, characterized in that an atraumatic tip (150, 550, 1706, 1706') on a distal end of the distal catheter member (120, 520, 1705, 1705'), the atraumatic tip (150, 550, 1706, 1706') having a substantially circular profile in a relaxed configuration with an unconnected end positioned proximate the longitudinal axis (131, 531, 1707, 1707'), the atraumatic tip (150, 550, 1706, 1706') being substantially solid along the circular profile, the atraumatic tip (150, 550, 1706, 1706') including a tip shaft (1705, 1705') with a guide lumen (1703, 1703') therein and having a substantially flattened cylindrical shape with an inner planar surface (455, 555, 1709, 1709'), an outer planar surface (457, 557) and opposing surfaces (458, 459, 558, 559), the guide lumen (1703, 1703') including an exit port (1702, 1702') proximate the distal end of the atraumatic tip (550, 1706, 1706') positioned proximate the longitudinal axis (131, 531, 1707, 1707'), the guide wire configured for slidable movement within the guide lumen (1703, 1703') and extendable out of the exit port (1702, 1702') beyond the atraumatic tip (150, 550, 1706, 1706').