mhurhangee/ep-ind-claims huggingface dataset:
An antibody-like binding protein comprising four polypeptide chains that form four antigen binding sites capable of specifically binding one or more antigen targets, wherein two polypeptide chains have a structure represented by the formula: V L1 -L 1 -V L2 -L 2 -C L and two polypeptide chains have a structure represented by the formula: V H2 -L 3 -V H1 -L 4 -C H1 -Fc wherein: V L1 is a first immunoglobulin light chain variable domain; V L2 is a second immunoglobulin light chain variable domain; V H1 is a first immunoglobulin heavy chain variable domain; V H2 is a second immunoglobulin heavy chain variable domain; C L is an immunoglobulin light chain constant domain; C H1 is the immunoglobulin C H1 heavy chain constant domain; Fc is the immunoglobulin hinge region and C H2, C H3 immunoglobulin heavy chain constant domains; and L 1, L 2, L 3, and L 4 are amino acid linkers; wherein the length of L 4 is at least twice the length of L 2; and the length of L 3 is at least twice the length of L 1; and wherein the linkers provide sufficient mobility for pairing of V L1 and V H1, and for pairing of V L2 and V H2, and the polypeptides of formula I and the polypeptides of formula II form a cross-over light chain-heavy chain pair. V L1 is a first immunoglobulin light chain variable domain; V L2 is a second immunoglobulin light chain variable domain; V H1 is a first immunoglobulin heavy chain variable domain; V H2 is a second immunoglobulin heavy chain variable domain; C L is an immunoglobulin light chain constant domain; C H1 is the immunoglobulin C H1 heavy chain constant domain; Fc is the immunoglobulin hinge region and C H2, C H3 immunoglobulin heavy chain constant domains; and L 1, L 2, L 3, and L 4 are amino acid linkers; wherein the length of L 4 is at least twice the length of L 2; and the length of L 3 is at least twice the length of L 1;
A method for the production of low-viscosity 2,4'-MDI based prepolymers carrying reactive NCO end groups having a reduced content of monomeric diisocyanates, characterised in that A) in a first synthesis step an NCO-terminated prepolymer which is liquid at ambient temperature having an NCO content > 15 wt.% is produced by reaction of a1) 2,4'-MDI having a content of at least 95 wt.% of the 2,4' isomer with a2) at least one diol having a molar mass of 62 g/mol to 700 g/mol or a mixture of mono- and/or di- and/or polyfunctional OH-functional components having an average functionality of ≥ 2.0 and a number average molar mass ≤ 700 g/mol a3) in a ratio of isocyanate groups to hydroxyl groups (index) of greater than 4:1 a4) optionally using a catalyst and B) in a second synthesis step, directly or at a later point in time, the b1) prepolymer produced in the first synthesis step A), which is liquid at ambient temperature, is reacted with b2) other polyols to form the polyurethane carrying reactive NCO end groups having a reduced content of monomeric diisocyanates with, at the same time, reduced viscosity. A) in a first synthesis step an NCO-terminated prepolymer which is liquid at ambient temperature having an NCO content > 15 wt.% is produced by reaction of a1) 2,4'-MDI having a content of at least 95 wt.% of the 2,4' isomer with a2) at least one diol having a molar mass of 62 g/mol to 700 g/mol or a mixture of mono- and/or di- and/or polyfunctional OH-functional components having an average functionality of ≥ 2.0 and a number average molar mass ≤ 700 g/mol a3) in a ratio of isocyanate groups to hydroxyl groups (index) of greater than 4:1 a4) optionally using a catalyst and a1) 2,4'-MDI having a content of at least 95 wt.% of the 2,4' isomer with a2) at least one diol having a molar mass of 62 g/mol to 700 g/mol or a mixture of mono- and/or di- and/or polyfunctional OH-functional components having an average functionality of ≥ 2.0 and a number average molar mass ≤ 700 g/mol a3) in a ratio of isocyanate groups to hydroxyl groups (index) of greater than 4:1 a4) optionally using a catalyst and B) in a second synthesis step, directly or at a later point in time, the b1) prepolymer produced in the first synthesis step A), which is liquid at ambient temperature, is reacted with b2) other polyols b1) prepolymer produced in the first synthesis step A), which is liquid at ambient temperature, is reacted with b2) other polyols
Device for applying treatment substance for treating a moving fiber web, which device comprises at least one nozzle comprising a channel for the treatment substance, a frame part, a tip or end of the nozzle and a treatment substance opening providing a treatment substance spray, which nozzle further comprises a tip groove area adjacent to the treatment substance opening, which nozzle comprises at least one opening next to or at the tip groove area for providing a cleaning fluid flow comprising gas and/or liquid to the tip groove area, characterized in that the tip or end of the nozzle is provided with insulation means and/or cooling means for managing the temperature of the tip or end.
A method of quantifying a wheat species-specific DNA in a test sample by polymerase chain reaction, the method comprising the steps of: amplifying a nucleic acid molecule having a partial sequence of a nucleotide sequence identified as SEQ ID NO: 1 using a nucleic acid molecule in the test sample or a nucleic acid molecule extracted from the test sample as a template and using a primer pair capable of amplifying the partial sequence of the nucleotide sequence identified as SEQ ID NO: 1; and quantifying the amplified nucleic acid molecule having the partial sequence of the nucleotide sequence identified as SEQ ID NO:1, wherein the primer pair is selected from the group consisting of: (i) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 5; and (ii) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 6. amplifying a nucleic acid molecule having a partial sequence of a nucleotide sequence identified as SEQ ID NO: 1 using a nucleic acid molecule in the test sample or a nucleic acid molecule extracted from the test sample as a template and using a primer pair capable of amplifying the partial sequence of the nucleotide sequence identified as SEQ ID NO: 1; and quantifying the amplified nucleic acid molecule having the partial sequence of the nucleotide sequence identified as SEQ ID NO:1, wherein the primer pair is selected from the group consisting of: (i) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 5; and (ii) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 6. (i) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 5; and (ii) a primer pair consisting of a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 4 and a nucleic acid molecule comprising the nucleotide sequence identified as SEQ ID NO: 6.
A continuous sterilization system (100, 200, 300) comprising: first conveying means for continuously conveying a cylindrical container by supporting the same from a side surface; a first electron beam accelerator for emitting an electron beam from the bottom surface portion side of said cylindrical container during conveyance by this first conveying means; second conveying means (30, 130) for continuously conveying said cylindrical container by supporting the same from the bottom surface portion side while rotating the same along a cylindrical shaft core of the cylindrical container; a second electron beam accelerator for emitting the electron beam over the entire periphery from the side surface portion side of said cylindrical container during conveyance by this second conveying means; a third electron beam accelerator for emitting the electron beam from the opening portion side to an inner surface portion of said cylindrical container during conveyance by said first conveying means or said second conveying means, characterized in that the system further comprises either (i) a spiral chute mechanism (50, 60) comprising two parallel guides (52, 62) arranged in a horizontal positional relationship with each other at the position of a belt conveyer, center parts of these two parallel guides are spirally rotated so as to reverse the positional relationship with each other by approximately 90 degrees; or (ii) a screw-conveyer mechanism having a screw conveyer and two guides, the screw conveyer forms a spiral in the horizontal direction and rotates while supporting the side surface of the cylindrical container in a groove position of this spiral, wherein the two guides are disposed to a position of the second conveying means so as to support the bottom surface of the cylindrical container and to reverse the cylindrical container by approximately 90 degrees from the upright state to the laterally directed state with rotation of the screw conveyer. first conveying means for continuously conveying a cylindrical container by supporting the same from a side surface; a first electron beam accelerator for emitting an electron beam from the bottom surface portion side of said cylindrical container during conveyance by this first conveying means; second conveying means (30, 130) for continuously conveying said cylindrical container by supporting the same from the bottom surface portion side while rotating the same along a cylindrical shaft core of the cylindrical container; a second electron beam accelerator for emitting the electron beam over the entire periphery from the side surface portion side of said cylindrical container during conveyance by this second conveying means; a third electron beam accelerator for emitting the electron beam from the opening portion side to an inner surface portion of said cylindrical container during conveyance by said first conveying means or said second conveying means,
A structural assembly for a motor vehicle comprising a stretcher line and an upper support cup for a suspension system of a wheel, the assembly comprising a wheel arch wall for said wheel, the assembly further comprising at least one sheet metal shaped to form a force path extending from the stretcher line towards the cup, the wheel arch wall being arranged between the cup, the force path and the stretcher line, the assembly comprising connecting member connecting the cup and the force path, the assembly being characterized in that the connecting member is shaped to deform in a predefined manner so as to transmit to the cup, along a transverse axis of the vehicle, at least a part of the longitudinal forces generated on the force path during a test with a reduced frontal overlapping.
An internal gear machining method for engaging an internal gear to be machined, which is rotatable about a work rotation axis, with a barrel-shaped screw-like tool (11,21), which is rotatable about a tool rotation axis disposed at a predetermined angle of axis intersection (Σ) with respect to the work rotation axis, and synchronously rotating the internal gear to be machined and the screw-like tool (11,21) in engagement with each other, thereby performing grinding of the internal gear to be machined, characterised in that the angle of axis intersection (Σ) for the grinding is set based on an outer diameter of the screw-like tool after dressing such that the state of contact between the screw-like tool after dressing and the internal gear to be machined is the same as the state of contact between the screw-like tool before dressing and the internal gear to be machined, the outer diameter of the screw-like tool after dressing being predicted before the dressing of the screw-like tool, the screw-like tool is dressed based on the set angle of axis intersection (Σ), and the dressed screw-like tool is disposed at the set angle of axis intersection (Σ), wherein a slip velocity during grinding before dressing is computed, and the number of rotations of the internal gear to be machined and the number of rotations of the screw-like tool (11,21) for grinding the internal gear to be machined after dressing are set based on the computed slip velocity, whereby the slip velocity during grinding after dressing can be rendered identical with the slip velocity before dressing.
Control device for at least one home automation apparatus, comprising: - a cover covering a capacitive sensor associated with an electronic circuit, - a light source driven by the electronic circuit and placed under the cover, - a light guide in the form of a straight cylinder or straight frustum and making it possible to direct the light emitted by the light source only towards an area of the cover situated inside the projection of the outer contour of the sensor on the cover in a direction normal to the detection face of the sensor, characterized in that the cover forms the light guide, in that the cover and the light guide are of a single piece, in that the material of the cover makes it possible to guide the light, in that the capacitive sensor surrounds the light source and in that the cover covers control members, the control members of the device comprising an electronic circuit and capacitive sensors, the light guide being part of a piece made of translucent material through which a light flux passes and that makes it possible to concentrate the light flux at a point of a user interface. - a cover covering a capacitive sensor associated with an electronic circuit, - a light source driven by the electronic circuit and placed under the cover, - a light guide in the form of a straight cylinder or straight frustum and making it possible to direct the light emitted by the light source only towards an area of the cover situated inside the projection of the outer contour of the sensor on the cover in a direction normal to the detection face of the sensor,
A support structure for a suspended toilet equipment, said equipment including a bowl, a drain pipe and a water tank, the support structure comprising two uprights and a cross member which links the two uprights and in which the upper portion of the bowl is intended to be fixed, each upright including an upper segment, located above the cross member, serving as a support for the tank and a lower segment intended to receive fixing feet to the ground, the support structure further comprising a bearing part which is located under the cross member and at a distance therefrom, and which links the two uprights, the bearing part being intended to serve as a bearing to the lower portion of the bowl, under the drain pipe; characterized in that the bearing part, the cross member, and at least the lower segment of the uprights are integrally made from a composite material comprising a plastic matrix filled with reinforcing fibers.
A composition comprising a multimeric polypeptide for use in a method of treating a human papilloma virus -associated cancer in a human patient, the method comprising administering a multimeric polypeptide and an immune checkpoint inhibitor, wherein the multimeric polypeptide comprises a heterodimer having: a) a first polypeptide comprising, in order from N-terminus to C-terminus: i) an HPV16 E7 epitope comprising the amino acid sequence YMLDLQPETT (SEQ ID NO:77); ii) a first major histocompatibility complex polypeptide being a β2-microglobulin (β2M) polypeptide comprising the amino acid sequence as depicted in FIG. 34A (SEQ ID NO:48); and b) a second polypeptide comprising, in order from N-terminus to C-terminus: i) a variant IL-2 polypeptide comprising the amino acid sequence depicted in FIG. 34B (SEQ ID NO: 49); ii) a second MHC polypeptide being a class I MHC heavy chain polypeptide comprising the amino acid sequence depicted in FIG. 34C (SEQ ID NO:50); and iii) an immunoglobulin (Ig) Fc polypeptide. a) a first polypeptide comprising, in order from N-terminus to C-terminus: i) an HPV16 E7 epitope comprising the amino acid sequence YMLDLQPETT (SEQ ID NO:77); ii) a first major histocompatibility complex polypeptide being a β2-microglobulin (β2M) polypeptide comprising the amino acid sequence as depicted in FIG. 34A (SEQ ID NO:48); and i) an HPV16 E7 epitope comprising the amino acid sequence YMLDLQPETT (SEQ ID NO:77); ii) a first major histocompatibility complex polypeptide being a β2-microglobulin (β2M) polypeptide comprising the amino acid sequence as depicted in FIG. 34A (SEQ ID NO:48); and b) a second polypeptide comprising, in order from N-terminus to C-terminus: i) a variant IL-2 polypeptide comprising the amino acid sequence depicted in FIG. 34B (SEQ ID NO: 49); ii) a second MHC polypeptide being a class I MHC heavy chain polypeptide comprising the amino acid sequence depicted in FIG. 34C (SEQ ID NO:50); and iii) an immunoglobulin (Ig) Fc polypeptide. i) a variant IL-2 polypeptide comprising the amino acid sequence depicted in FIG. 34B (SEQ ID NO: 49); ii) a second MHC polypeptide being a class I MHC heavy chain polypeptide comprising the amino acid sequence depicted in FIG. 34C (SEQ ID NO:50); and iii) an immunoglobulin (Ig) Fc polypeptide.
A coupling member for coupling together a first section and a second section of a pipe machining apparatus, the coupling member comprising: a first housing member adapted to couple to the first section, wherein the first housing member includes a surface engageable with the first section with the first housing member coupled to the first section; a second housing member adapted to couple to the second section; a shaft coupled to the first housing member and defining an axis extending through a longitudinal center thereof, wherein the axis is substantially perpendicular to the surface of the first housing member; an arm rotatably coupled to the shaft and rotatable about the axis; and an engagement member coupled to the arm; wherein the arm is adapted to rotate between a coupled condition, in which the engagement member engages the second housing member, and an uncoupled condition, in which the engagement member does not engage the second housing member, wherein the first housing member includes a projection and the second housing member includes a receptacle adapted to receive the projection therein; characterized in that the projection includes arcuate surfaces and chamfered edges, and the receptacle includes arcuate surfaces, and wherein, during assembly of the first and second sections, arcuate surfaces (168, 212) of the projection and the receptacle are adapted to engage each other to move misaligned first and second sections (24B, 24A) into proper alignment for coupling together. a first housing member adapted to couple to the first section, wherein the first housing member includes a surface engageable with the first section with the first housing member coupled to the first section; a second housing member adapted to couple to the second section; a shaft coupled to the first housing member and defining an axis extending through a longitudinal center thereof, wherein the axis is substantially perpendicular to the surface of the first housing member; an arm rotatably coupled to the shaft and rotatable about the axis; and an engagement member coupled to the arm; wherein the arm is adapted to rotate between a coupled condition, in which the engagement member engages the second housing member, and an uncoupled condition, in which the engagement member does not engage the second housing member, wherein the first housing member includes a projection and the second housing member includes a receptacle adapted to receive the projection therein; characterized in that the projection includes arcuate surfaces and chamfered edges, and the receptacle includes arcuate surfaces, and wherein, during assembly of the first and second sections, arcuate surfaces (168, 212) of the projection and the receptacle are adapted to engage each other to move misaligned first and second sections (24B, 24A) into proper alignment for coupling together.
A process for producing a porous polymer composition, comprising the steps of providing a substrate; preparing a polymer solution containing a polymer composition, a solvent, and optionally a non-solvent, wherein the polymer composition has a weight average molecular weight M w determined by size exclusion chromatography as specified in the description of 80 to 400 kg/mol, a number average molecular weight M n determined by size exclusion as specified in the description chromatography of 60 to 200 kg/mol, and a polydispersity index D (D=M w /M n) of 1.1 to 2; and forming a film of the polymer solution on the substrate; and evaporating the solvent from the film of the polymer solution, thereby obtaining the porous polymer composition, wherein the polymer composition comprises poly(methyl methacrylate). providing a substrate; preparing a polymer solution containing a polymer composition, a solvent, and optionally a non-solvent, wherein the polymer composition has a weight average molecular weight M w determined by size exclusion chromatography as specified in the description of 80 to 400 kg/mol, a number average molecular weight M n determined by size exclusion as specified in the description chromatography of 60 to 200 kg/mol, and a polydispersity index D (D=M w /M n) of 1.1 to 2; and a weight average molecular weight M w determined by size exclusion chromatography as specified in the description of 80 to 400 kg/mol, a number average molecular weight M n determined by size exclusion as specified in the description chromatography of 60 to 200 kg/mol, and a polydispersity index D (D=M w /M n) of 1.1 to 2; and forming a film of the polymer solution on the substrate; and evaporating the solvent from the film of the polymer solution, thereby obtaining the porous polymer composition,
A brake calliper of a disc brake comprising two brake application struts which run essentially parallel to one another a certain distance apart and which connect rigidly together a calliper back and a housing having a receiving chamber for operating parts, characterised in that starting from the calliper back and running along the length of its inner face facing the other brake application strut at least one of the brake application struts has a convex recess which transitions into a concave recess, the transition between the convex recess and the concave recess being rounded.