A compound of Formula I: or a pharmaceutically acceptable salt, polymorphic form, solvate, hydrate or tautomeric form thereof; wherein: A is aryl or heteroaryl; each R 1 is independently selected from the group consisting of X-R 2, halogen, deuterium, C 1-6 alkyl, O-C 1-6 alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, -CN, -C OR 3, -C NR 4 R 5, -S 2 NR 4 R 5, -S 2 R 6, -NR 8 C R 9, and -NR 8 S 2 R 9; wherein each C 1-6 alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3 and -O-CF 3; X is selected from the group consisting of O, CH 2, OCH 2, CH 2 O, CH 2 S 2, CONH and NHCO; R 2 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl; wherein each R 2 is optionally substituted by one or more R 7; R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3 and -O-CF 3; R 4 and R 5 are independently selected from the group consisting of hydrogen, C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, - CH 2 CF 3 and -O-CF 3; or R 4 and R 5 when attached to the same nitrogen atom are combined to form a 4- to 7-membered ring having from 0 to 1 additional heteroatoms as ring members; R 6 is selected from the group consisting of C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3, and -O-CF 3; R 7 is selected from the group consisting of halogen, -OH, C 1-6 alkyl, O-C 1-6 alkyl C 3-7 cycloalkyl, -C OR 3, -C NR 4 R 5, -NR 4 C R 6, -S 2 NR 4 R 5, -NR 4 S 2 R 6 and -S 2 R 6; wherein each C 1-6 alkyl is optionally substituted by one or more substituents selected from the group consisting of halogen and -OH; R 8 is hydrogen or C 1-6 alkyl; R 9 is selected from the group consisting of C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3, and -O-CF 3; or R 8 and R 9 are combined to form a 5- to 7-membered ring having from 0 to 1 additional heteroatoms as ring members; and n is 0, 1, 2, 3, 4, 5 or 6. A is aryl or heteroaryl; each R 1 is independently selected from the group consisting of X-R 2, halogen, deuterium, C 1-6 alkyl, O-C 1-6 alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, -CN, -C OR 3, -C NR 4 R 5, -S 2 NR 4 R 5, -S 2 R 6, -NR 8 C R 9, and -NR 8 S 2 R 9; wherein each C 1-6 alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3 and -O-CF 3; X is selected from the group consisting of O, CH 2, OCH 2, CH 2 O, CH 2 S 2, CONH and NHCO; R 2 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl; wherein each R 2 is optionally substituted by one or more R 7; R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3 and -O-CF 3; R 4 and R 5 are independently selected from the group consisting of hydrogen, C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -SO 2 CH 3, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, - CH 2 CF 3 and -O-CF 3; or R 4 and R 5 when attached to the same nitrogen atom are combined to form a 4- to 7-membered ring having from 0 to 1 additional heteroatoms as ring members; R 6 is selected from the group consisting of C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3, and -O-CF 3; R 7 is selected from the group consisting of halogen, -OH, C 1-6 alkyl, O-C 1-6 alkyl C 3-7 cycloalkyl, -C OR 3, -C NR 4 R 5, -NR 4 C R 6, -S 2 NR 4 R 5, -NR 4 S 2 R 6 and -S 2 R 6; wherein each C 1-6 alkyl is optionally substituted by one or more substituents selected from the group consisting of halogen and -OH; R 8 is hydrogen or C 1-6 alkyl; R 9 is selected from the group consisting of C 1-6 alkyl and C 3-7 cycloalkyl; wherein each C 1-6 alkyl and C 3-7 cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, -OH, -C 1-4 alkyl, -O-C 1-4 alkyl, -CF 3, -CH 2 CF 3, and -O-CF 3; or R 8 and R 9 are combined to form a 5- to 7-membered ring having from 0 to 1 additional heteroatoms as ring members; and n is 0, 1, 2, 3, 4, 5 or 6.