mhurhangee/ep-ind-claims huggingface dataset:
A sex toy for insertion into the body of a wearer and a partner at the same time, comprising: (a) a first elongated, resilient, and generally cylindrical rear end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions (52, 54); (b) a second elongated, resilient, and generally cylindrical front end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions (66, 68); and (c) a centre region, wherein said first and said second end regions (50, 60) connect with opposing ends of said centre region, characterised by a means for attaching attached to a point of attachment on said centre region, wherein said means for attaching is capable of going around the wearer's penis or a strap on dildo worn by the wearer with said rear end region received in the wearer's anus and the front end region inserted in the partner's anus or vagina to enable simultaneous anal penetration of the wearer while performing anal or vaginal intercourse with the partner and said means for attaching and said point of attachment create a fulcrum or pivot point for transferring kinetic energy from one of said end regions (50, 60) to the other of said end regions (50, 60). (a) a first elongated, resilient, and generally cylindrical rear end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions (52, 54); (b) a second elongated, resilient, and generally cylindrical front end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions (66, 68); and (c) a centre region, wherein said first and said second end regions (50, 60) connect with opposing ends of said centre region, characterised by a means for attaching attached to a point of attachment on said centre region, wherein said means for attaching is capable of going around the wearer's penis or a strap on dildo worn by the wearer with said rear end region received in the wearer's anus and the front end region inserted in the partner's anus or vagina to enable simultaneous anal penetration of the wearer while performing anal or vaginal intercourse with the partner and said means for attaching and said point of attachment create a fulcrum or pivot point for transferring kinetic energy from one of said end regions (50, 60) to the other of said end regions (50, 60).
A gantry structure designed for pivoting about an axis of rotation and for delivering a hadron beam on a target, said gantry structure comprising: a beam delivery line receiving said hadron beam in a direction essentially parallel to said axis of rotation, deviating it away from said axis of rotation and delivering it so that the axis of the beam intersects said axis of rotation; and a counterweight supported on the other side of said axis of rotation for compensating a moment of force due to the weight of said beam delivery line; characterized in that said gantry structure further comprises: a pivotable support arm supported by a support structure so as to be capable of pivoting about said axis of rotation, wherein said beam delivery line is a self-supporting structure supported by said pivotable support arm in proximity of the center of gravity of the beam delivery line, and said counterweight is supported by an extension of said pivotable support arm, and wherein said pivotable support arm has a plane of symmetry that is perpendicular to said axis of rotation and contains the center of gravity of said beam delivery line. a pivotable support arm supported by a support structure so as to be capable of pivoting about said axis of rotation, wherein said beam delivery line is a self-supporting structure supported by said pivotable support arm in proximity of the center of gravity of the beam delivery line, and said counterweight is supported by an extension of said pivotable support arm, and wherein said pivotable support arm has a plane of symmetry that is perpendicular to said axis of rotation and contains the center of gravity of said beam delivery line.
An anti-IL-4R antibody or an antigen-binding fragment thereof, comprising any one selected from the following (i) to (iii): (i) a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8, respectively; (ii) a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 38, SEQ ID NO: 7 and SEQ ID NO: 40, respectively; (iii) a heavy chain variable region, comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5 respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 42, SEQ ID NO: 39 and SEQ ID NO: 8, respectively. (i) a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8, respectively; (ii) a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 38, SEQ ID NO: 7 and SEQ ID NO: 40, respectively; (iii) a heavy chain variable region, comprising HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5 respectively; and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO: 42, SEQ ID NO: 39 and SEQ ID NO: 8, respectively.
Device for locking wheel rims for vehicles on repair workshop machines, particularly tyre-changing machines or the like, comprising fastening means associable in a removable way with supporting means of the rim of a wheel in a vehicle repair workshop machine, at least a stop element engageable on a rim arranged on said supporting means for locking the rim itself and at least an extremal section of substantially elongated shape which can be fitted in a corresponding housing on said supporting means of the rim, characterised by the fact that it comprises simultaneous movement means associated with said fastening means and with said stop element and suitable for simultaneously moving said fastening means and said stop element between a release configuration, wherein said fastening means are released from said supporting means and said stop element is substantially disengaged from said rim, and a locking configuration, wherein said fastening means are associated with said supporting means and said stop element is engaged on said rim, and by the fact that said fastening means comprise at least an expansion clamp element made along at least a portion of said extremal section and suitable for being expanded to engage on the inner surface of said housing in said locking configuration.
A method in a probe, comprising: sending to a first Internet device an application layer request message and a lower layer request message associated with the application layer request message, and responsively receiving from the first Internet device an application layer response message and one or more lower layer continuation messages; determining latencies of the application layer response message and of the one or more lower layer continuation messages; and comparing the determined latencies with respective reference values to identify a likely honeypot. sending to a first Internet device an application layer request message and a lower layer request message associated with the application layer request message, and responsively receiving from the first Internet device an application layer response message and one or more lower layer continuation messages; determining latencies of the application layer response message and of the one or more lower layer continuation messages; and comparing the determined latencies with respective reference values to identify a likely honeypot.
DC-to-DC converter having a first sub-converter and a second sub-converter that are connected in series with one another, forming a converter series circuit, wherein the converter series circuit extends between a first and a second high voltage-side DC voltage pole (5, 6) and the second sub-converter extends between a first and a second low voltage-side DC voltage pole (7, 8), wherein an AC voltage terminal of the first sub-converter and an AC voltage terminal of the second sub-converter are connected via a coupling device, wherein the coupling device provides purely capacitive coupling of the sub-converters (2, 3), characterized in that the coupling device comprises at least one series circuit of two-pole coupling modules, wherein each coupling module comprises at least a power semiconductor switch (102, 104) and a capacitor, wherein the capacitors of the coupling modules are able to be activated or to be bridged by way of a controller for driving the power semiconductor switches.
A process for improving the stability of yttrium stabilised zirconia for dental restorations comprising yttrium stabilised zirconia, the dental restorations are veneered with a dental ceramic veneering material comprising the steps: - providing a dental restoration comprising yttrium stabilised zirconia and to be veneered; - applying the dental ceramic veneering material to the dental restoration by spraying-on an aerosol which contains the dental ceramic veneering material and water-free propellant; - firing the resulting arrangement to a resulting veneered dental restoration, wherein wherein the propellant is selected from the group consisting of aerosols based on heptafluoro propane or propane, Butane or mixtures thereof and wherein the dental ceramic veneering material is applied in a thickness from 0.01 mm to 0.5 mm. - providing a dental restoration comprising yttrium stabilised zirconia and to be veneered; - applying the dental ceramic veneering material to the dental restoration by spraying-on an aerosol which contains the dental ceramic veneering material and water-free propellant; - firing the resulting arrangement to a resulting veneered dental restoration, wherein wherein the propellant is selected from the group consisting of aerosols based on heptafluoro propane or propane, Butane or mixtures thereof and wherein the dental ceramic veneering material is applied in a thickness from 0.01 mm to 0.5 mm. wherein the propellant is selected from the group consisting of aerosols based on heptafluoro propane or propane, Butane or mixtures thereof and wherein the dental ceramic veneering material is applied in a thickness from 0.01 mm to 0.5 mm.
An oral care instrument for applying a gel or cream oral composition in an oral cavity by discharging the oral composition from a nozzle portion (10, 83a, 88a, 90, 95a) at a distal end of the instrument, comprising: a handle body gripped when used; a head body having the nozzle portion (10, 83a, 88a, 90, 95a) for discharging the oral composition at the distal end of the instrument; and a neck body which is formed between the handle body and the head body and by which the head body can be inserted to deep portions in the oral cavity, wherein a supply path for supplying the oral composition from the handle body to the nozzle portion (10, 83a, 88a, 90, 95a) of the head body through an inner side of the neck body is provided, the head body is detachably coupled to the neck body, and a brush body for cleaning interdental spaces is provided at a distal end of the head body, the nozzle portion is opened toward a brush portion of the brush body, the head body is formed into a bent shape, a base side supply path and a distal end side supply path of the head body are formed at an angle to each other, characterised in that the distal end side supply path of the head body is formed by a through hole passing through a distal end side portion of the head body, and a lid member for occluding an opening at a base end of the through hole is fixed to a base of the distal end side portion of the head body. a handle body gripped when used; a head body having the nozzle portion (10, 83a, 88a, 90, 95a) for discharging the oral composition at the distal end of the instrument; and a neck body which is formed between the handle body and the head body and by which the head body can be inserted to deep portions in the oral cavity, wherein a supply path for supplying the oral composition from the handle body to the nozzle portion (10, 83a, 88a, 90, 95a) of the head body through an inner side of the neck body is provided, the head body is detachably coupled to the neck body, and a brush body for cleaning interdental spaces is provided at a distal end of the head body, the nozzle portion is opened toward a brush portion of the brush body, the head body is formed into a bent shape, a base side supply path and a distal end side supply path of the head body are formed at an angle to each other, characterised in that the distal end side supply path of the head body is formed by a through hole passing through a distal end side portion of the head body, and a lid member for occluding an opening at a base end of the through hole is fixed to a base of the distal end side portion of the head body.
A method for the prognosis as early as at the time of diagnosis of acute lymphoblastic leukemia in a mammalian subject, whereby preventing overtreatment or under treatment of said ALL in said subject, which method comprises the steps of: (a) contacting detecting nucleic acid molecules specific for both miR-151-5p and miR-451 and at least one suitable control reference gene or miRNA, with a test sample of said subject or with any nucleic acid product obtained therefrom, and optionally with a suitable control sample; (b) determining the expression value of both miR-151-5p and miR-451 in said test sample, and optionally, in a suitable control sample; (c) determining the expression value of at least one suitable control reference gene or miRNA in said test sample, and optionally, in a suitable control sample; (d) normalizing the expression value of said both miR-151-5p and miR-451 obtained in step (b) according to the expression value of said least one suitable control reference gene or miRNA obtained in step (c); (e) comparing the normalized expression value obtained in step (d) with a corresponding predetermined cutoff value or with a normalized expression value of both miR-151-5p and miR-451 obtained from a suitable control sample according to step (b); wherein a positive normalized expression value of said both miR-151-5p and miR-451 indicates that said subject belongs to a patient population associated with a specific relapse rate which is higher than the specific relapse rate in a patient population where said both miR-151-5p and miR-451 have a negative normalized expression value. (a) contacting detecting nucleic acid molecules specific for both miR-151-5p and miR-451 and at least one suitable control reference gene or miRNA, with a test sample of said subject or with any nucleic acid product obtained therefrom, and optionally with a suitable control sample; (b) determining the expression value of both miR-151-5p and miR-451 in said test sample, and optionally, in a suitable control sample; (c) determining the expression value of at least one suitable control reference gene or miRNA in said test sample, and optionally, in a suitable control sample; (d) normalizing the expression value of said both miR-151-5p and miR-451 obtained in step (b) according to the expression value of said least one suitable control reference gene or miRNA obtained in step (c); (e) comparing the normalized expression value obtained in step (d) with a corresponding predetermined cutoff value or with a normalized expression value of both miR-151-5p and miR-451 obtained from a suitable control sample according to step (b);
Casing of a turbine engine, notably for a compressor (4; 6) of an axial turbine engine, the casing comprising: - a wall, and - at least one fastening flange associated with the wall, the fastening flange comprising a fastening surface that can be applied against a corresponding mounting surface of the turbine engine, or against another fastening surface, characterized in that the fastening flange comprises at least one electrical connector with one end lying flush with the fastening surface of said fastening flange and in that the wall is a first wall, the casing further comprising a second wall with a fastening flange and electrical connector identical or similar to those associated with the first wall, the fastening flanges (30A; 30B) being fastened together so as to provide an electrical contact between the connectors. - a wall, and - at least one fastening flange associated with the wall, the fastening flange comprising a fastening surface that can be applied against a corresponding mounting surface of the turbine engine, or against another fastening surface,
A probe, comprising: a piezoelectric layer to generate ultrasonic waves; a backing layer to absorb ultrasonic waves generated at the piezoelectric layer and proceeding toward a rear; a reflective layer occupying an area smaller than an area of the piezoelectric layer and provided in between the piezoelectric layer and the backing layer to amplify the ultrasonic waves generated at the piezoelectric layer; and a lens layer to focus the ultrasonic waves proceeding toward a front of the piezoelectric layer at a certain point, wherein the reflective layer is configured to be formed of material having an acoustic impedance higher than an acoustic impedance of the piezoelectric layer, and occupy a shorter length in an elevation direction of the probe than a length of the piezoelectric layer. a piezoelectric layer to generate ultrasonic waves; a backing layer to absorb ultrasonic waves generated at the piezoelectric layer and proceeding toward a rear; a reflective layer occupying an area smaller than an area of the piezoelectric layer and provided in between the piezoelectric layer and the backing layer to amplify the ultrasonic waves generated at the piezoelectric layer; and a lens layer to focus the ultrasonic waves proceeding toward a front of the piezoelectric layer at a certain point, wherein the reflective layer is configured to be formed of material having an acoustic impedance higher than an acoustic impedance of the piezoelectric layer, and occupy a shorter length in an elevation direction of the probe than a length of the piezoelectric layer.
A wear-resistant tool being a wire drawing die comprising composite polycrystalline diamond as a core, the composite polycrystalline diamond being composed of polycrystalline diamond in which particulate diamond is directly bonded, the wear-resistant tool being characterized in that, the composite polycrystalline diamond is also composed of non diamond carbon, and in that, a length of a bearing portion is not smaller than 0.2D and not greater than 1.0D where D represents a diameter of the bearing portion of a hole profile.
Cooling ring of an apparatus for the production of blown films, said cooling ring comprising a device to adjust the thickness profile of said films, said device comprising a plurality of actuators (5, 6) equally spaced in the circumferential direction and arranged in adjustment chambers of the cooling ring where they adjust by means of motorized shutters or valves the flow rate of the flow of a cooling fluid directed towards a forming cone of the cooling ring, as well as a plurality of heating elements (11, 12), characterized in that said heating elements (11, 12) are equally spaced in the circumferential direction in said adjustment chambers and are sequentially arranged with respect to said actuators (5, 6) in the path of the cooling fluid through the adjustment chambers.
Method for preparation of a sample of a formulation for subsequent endotoxin determination, the formulation suspected of comprising an endotoxin, the formulation preferentially being a pharmaceutical formulation, wherein factors or inhibitory components interfering with endotoxin determination methods are removed from the formulation; the method comprising the following steps: - application of the sample to an endotoxin-free centrifugation column containing a size exclusion chromatography gel matrix that has been equilibrated with a suitable equilibration buffer; - wherein a size exclusion chromatography gel matrix with a size exclusion volume or exclusion cut-off within the range of 2.000 Dalton to 20.000 Dalton is used, especially wherein the size exclusion chromatography gel matrix or resin has a size exclusion volume or exclusion cut-off between 4.000 Dalton to 7.000 Dalton, especially below 6.000 Dalton; - and wherein the size exclusion chromatography gel matrix has a high mechanical stability at centrifugation forces of up to 1.800g; - elution of a flow through of the sample by centrifugation, - wherein the centrifugation step separates monomeric LPS, large LPS complex or LPS aggregate from the small components of the formulation; - wherein the small components remain within the size exclusion chromatography gel matrix and wherein - the monomeric LPS, large LPS complex or LPS aggregate can be found after the centrifugation step in the flow through; - which flow through can then be used for endotoxin determination. - application of the sample to an endotoxin-free centrifugation column containing a size exclusion chromatography gel matrix that has been equilibrated with a suitable equilibration buffer; - wherein a size exclusion chromatography gel matrix with a size exclusion volume or exclusion cut-off within the range of 2.000 Dalton to 20.000 Dalton is used, especially wherein the size exclusion chromatography gel matrix or resin has a size exclusion volume or exclusion cut-off between 4.000 Dalton to 7.000 Dalton, especially below 6.000 Dalton; - and wherein the size exclusion chromatography gel matrix has a high mechanical stability at centrifugation forces of up to 1.800g; - elution of a flow through of the sample by centrifugation, - wherein the centrifugation step separates monomeric LPS, large LPS complex or LPS aggregate from the small components of the formulation; - wherein the small components remain within the size exclusion chromatography gel matrix and wherein - the monomeric LPS, large LPS complex or LPS aggregate can be found after the centrifugation step in the flow through; - which flow through can then be used for endotoxin determination.
Gripper for a gripper weaving machine comprising a gripper profile and a clamp with a first jaw and a second jaw for clamping a weft thread between the first jaw and the second jaw, wherein the first jaw is attached fixedly in position to the gripper profile, and wherein at least a front end of the second jaw is moveable with respect to the first jaw, characterized in that the first jaw has a mounting part provided with a slot for pinning the mounting part over the gripper profile.