A positioning method for different TDD uplink-downlink configurations, wherein when a primary cell, PCell, and a serving cell, SCell, that are of user equipment, UE, have different uplink-downlink configurations at a same subframe location, and the UE does not support simultaneous transmission and reception, the method comprises: receiving, by a first device, positioning information of the UE, wherein the positioning information comprises positioning assistance information, or positioning assistance information and a UE identifier, and the positioning assistance information comprises at least positioning reference signal, PRS, information, or PRS information and a Cell ID; and determining, by the first device and according to the positioning information, that the UE performs PRS measurement at the same subframe location of the SCell, and avoiding, by the first device, scheduling data or configuring a sounding signal sounding at the same subframe location of the PCell and the SCell that have different configurations wherein the first device is a serving base station or a target base station, and wherein the avoiding, by the first device, scheduling data or configuring a sounding signal sounding at the same subframe location of the PCell and the SCell that have different configurations comprises: if a subframe at the same subframe location of the PCell is a downlink subframe, skipping, by the first device, scheduling the downlink subframe; or if a subframe at the same subframe location of the PCell is an uplink subframe, skipping, by the first device, scheduling the uplink subframe or configuring a sounding signal; or if a subframe at the same subframe location of the PCell is a special subframe, skipping, by the first device, scheduling the special subframe. receiving, by a first device, positioning information of the UE, wherein the positioning information comprises positioning assistance information, or positioning assistance information and a UE identifier, and the positioning assistance information comprises at least positioning reference signal, PRS, information, or PRS information and a Cell ID; and determining, by the first device and according to the positioning information, that the UE performs PRS measurement at the same subframe location of the SCell, and avoiding, by the first device, scheduling data or configuring a sounding signal sounding at the same subframe location of the PCell and the SCell that have different configurations wherein the first device is a serving base station or a target base station, and wherein the avoiding, by the first device, scheduling data or configuring a sounding signal sounding at the same subframe location of the PCell and the SCell that have different configurations comprises: if a subframe at the same subframe location of the PCell is a downlink subframe, skipping, by the first device, scheduling the downlink subframe; or if a subframe at the same subframe location of the PCell is an uplink subframe, skipping, by the first device, scheduling the uplink subframe or configuring a sounding signal; or if a subframe at the same subframe location of the PCell is a special subframe, skipping, by the first device, scheduling the special subframe. if a subframe at the same subframe location of the PCell is a downlink subframe, skipping, by the first device, scheduling the downlink subframe; or if a subframe at the same subframe location of the PCell is an uplink subframe, skipping, by the first device, scheduling the uplink subframe or configuring a sounding signal; or if a subframe at the same subframe location of the PCell is a special subframe, skipping, by the first device, scheduling the special subframe.