mhurhangee/ep-ind-claims huggingface dataset:
A medical device, comprising: an elongate core member having a proximal section and a distal section; a tubular member disposed about the distal section of the core member, the tubular member having a plurality of slots formed therein; and a tip member; wherein the distal section of the core member and the tubular member define a distal tip for the medical device, the distal tip having a proximal end and a distal end and being free of a shaping ribbon; the medical device being characterized by: the elongate core member including a super elastic nickel-titanium alloy; the tubular member including a nickel-chromium-molybdenum alloy; wherein the distal section of the core member is coupled to the tip member; wherein adjacent to the proximal end of the distal tip, the distal tip has super elastic characteristics dominated by the shapability characteristics of the super elastic core member; wherein adjacent to the distal end of the distal tip, the distal tip is shapeable, and wherein between the proximal end of the distal tip and the distal end of the distal tip, the core member tapers so that the distal tip transitions from having the super elastic characteristics of the core member to being shapeable. an elongate core member having a proximal section and a distal section; a tubular member disposed about the distal section of the core member, the tubular member having a plurality of slots formed therein; and a tip member; wherein the distal section of the core member and the tubular member define a distal tip for the medical device, the distal tip having a proximal end and a distal end and being free of a shaping ribbon; the elongate core member including a super elastic nickel-titanium alloy; the tubular member including a nickel-chromium-molybdenum alloy; wherein the distal section of the core member is coupled to the tip member; wherein adjacent to the proximal end of the distal tip, the distal tip has super elastic characteristics dominated by the shapability characteristics of the super elastic core member; wherein adjacent to the distal end of the distal tip, the distal tip is shapeable, and wherein between the proximal end of the distal tip and the distal end of the distal tip, the core member tapers so that the distal tip transitions from having the super elastic characteristics of the core member to being shapeable.
A vibratory flow meter comprising an emitter-sensor assembly for measuring a spatiotemporal relationship between two positions of a vibratory flow tube of the vibratory flow meter, comprising: an emitter substantially rigidly coupled to a first position of the vibratory flow tube to move with the first position, the emitter configured to emit electro-magnetic radiation towards a second position of the vibratory flow tube; and a sensor substantially rigidly coupled to the first position of the vibratory flow tube to move with the first position, the sensor configured to receive the electro-magnetic radiation reflected from a reflective surface that is rigidly coupled to the second position of the vibratory flow tube, wherein the sensor is a position sensor detector configured to detect the position of the electro-magnetic radiation on a sensing area of a two-axis position sensitive detector or on an array of photo-sensitive diodes with a gridded coordinate system. an emitter substantially rigidly coupled to a first position of the vibratory flow tube to move with the first position, the emitter configured to emit electro-magnetic radiation towards a second position of the vibratory flow tube; and a sensor substantially rigidly coupled to the first position of the vibratory flow tube to move with the first position, the sensor configured to receive the electro-magnetic radiation reflected from a reflective surface that is rigidly coupled to the second position of the vibratory flow tube, wherein the sensor is a position sensor detector configured to detect the position of the electro-magnetic radiation on a sensing area of a two-axis position sensitive detector or on an array of photo-sensitive diodes with a gridded coordinate system.
A satellite (100, 200), comprising: a body (108, 210) having an additively manufactured external wall structure at least partially forming an enclosed compartment; a propellant tank; and a communication device (118, 218) attached to the body (108, 210), configured to receive and transmit data while in space, wherein: the external wall structure includes an additively manufactured aft panel connected to a separation system (106, 214) configured to mount and carry the body (108, 210) inside a launch vehicle during a launch phase, and to release the body (108, 210) from the launch vehicle after the launch phase; the additively manufactured aft panel includes an inner skin, an outer skin, and side walls; the additively manufactured aft panel comprises multiple thruster bracket interface rings and a central interface ring comprising an inner annular surface of the inner skin and an outer annular surface of the outer skin; and the central interface ring connects to the propellant tank and the separation system (106,214), wherein the propellant tank is mounted to the inner annular surface and the separation system (106,214) is mounted to the outer annular surface. a body (108, 210) having an additively manufactured external wall structure at least partially forming an enclosed compartment; a propellant tank; and a communication device (118, 218) attached to the body (108, 210), configured to receive and transmit data while in space, wherein: the external wall structure includes an additively manufactured aft panel connected to a separation system (106, 214) configured to mount and carry the body (108, 210) inside a launch vehicle during a launch phase, and to release the body (108, 210) from the launch vehicle after the launch phase; the additively manufactured aft panel includes an inner skin, an outer skin, and side walls; the additively manufactured aft panel comprises multiple thruster bracket interface rings and a central interface ring comprising an inner annular surface of the inner skin and an outer annular surface of the outer skin; and the central interface ring connects to the propellant tank and the separation system (106,214), wherein the propellant tank is mounted to the inner annular surface and the separation system (106,214) is mounted to the outer annular surface. the external wall structure includes an additively manufactured aft panel connected to a separation system (106, 214) configured to mount and carry the body (108, 210) inside a launch vehicle during a launch phase, and to release the body (108, 210) from the launch vehicle after the launch phase; the additively manufactured aft panel includes an inner skin, an outer skin, and side walls; the additively manufactured aft panel comprises multiple thruster bracket interface rings and a central interface ring comprising an inner annular surface of the inner skin and an outer annular surface of the outer skin; and the central interface ring connects to the propellant tank and the separation system (106,214), wherein the propellant tank is mounted to the inner annular surface and the separation system (106,214) is mounted to the outer annular surface.
A controlled-release formulation, composed of a core and a coating layer, and comprising quetiapine or a pharmaceutically acceptable salt, solvate, or polymorph of quetiapine, characterized in that I) the total core weight comprises a) sodium citrate dihydrate at 1 to 10% by weight, and II) the total coating weight comprises a) ethyl cellulose at 20 to 45% by weight, b) triethyl citrate at 8 to 18% by weight, and c) sodium phosphate at 5 to 15% by weight. I) the total core weight comprises a) sodium citrate dihydrate at 1 to 10% by weight, and a) sodium citrate dihydrate at 1 to 10% by weight, and II) the total coating weight comprises a) ethyl cellulose at 20 to 45% by weight, b) triethyl citrate at 8 to 18% by weight, and c) sodium phosphate at 5 to 15% by weight. a) ethyl cellulose at 20 to 45% by weight, b) triethyl citrate at 8 to 18% by weight, and c) sodium phosphate at 5 to 15% by weight.
An oral pharmaceutical composition comprising 25.0% by weight of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid or a pharmaceutically acceptable salt thereof; 25.7% by weight of a suspending agent refined polydextrose; 25.0% by weight of a binding agent mannitol; a surfactant agent selected from 12.8% by weight of polyethylene glycol 3350 and 3.7% by weight of poloxamer 407 powder; 5.0% by weight of a disintegrant crospovidone; and less than 2% by weight of a further excipient selected from hydroxyethyl cellulose, vanilla flavor, non-bovine magnesium stearate and colloidal silica, for use in a method of treatment of a disease associated with a lack of expression of a gene resulting from a premature stop codon, wherein said disease is Cystic Fibrosis or Duchenne Muscular Dystrophy, wherein the composition is a powder, and wherein the method comprises administration of three doses of the effective amount of 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid or a pharmaceutically acceptable salt thereof in a 24 hour period according to the formula: 1X, 1X, 2X, wherein X is 20 mg/kg.
A method for wireless communications by an apparatus, comprising: obtaining a frame received over a medium; detecting an occurrence of an error when processing the frame; determining an intended recipient of the frame based on information included in the frame; and selecting a first or second deferral period, after detecting the occurrence of the error, during which the apparatus refrains from transmitting on the medium; wherein the selecting comprises: selecting said first deferral period if the determination is that the apparatus is the intended recipient of the frame; or selecting said second deferral period if the determination is that the apparatus is not the intended recipient of the frame, wherein the first deferral period is less than the second deferral period. obtaining a frame received over a medium; detecting an occurrence of an error when processing the frame; determining an intended recipient of the frame based on information included in the frame; and selecting a first or second deferral period, after detecting the occurrence of the error, during which the apparatus refrains from transmitting on the medium; selecting said first deferral period if the determination is that the apparatus is the intended recipient of the frame; or selecting said second deferral period if the determination is that the apparatus is not the intended recipient of the frame, wherein the first deferral period is less than the second deferral period.
A truck cabin for a truck, comprising a windshield, a driver's seat, a steering wheel, a dashboard and a projector configured to project an image onto the steering wheel, characterized in that: - the image projected by the projector onto the steering wheel is configured to comprise information about the operation of the truck, and - in a first direction of sight of a driver sitting in the driver's seat and looking at the steering wheel, the dashboard does not comprise any other information displays about the operation of the truck, and in that the projector is configured to adapt the image projected onto the steering wheel, depending on a steering angle of the steering wheel. - the image projected by the projector onto the steering wheel is configured to comprise information about the operation of the truck, and - in a first direction of sight of a driver sitting in the driver's seat and looking at the steering wheel, the dashboard does not comprise any other information displays about the operation of the truck,
A plug element for a sealed high-voltage plug-and-socket connector, by means of which, in particular in an automobile, an electrical conductor can be connected in electrically conductive manner to a mating contact element of a mating plug element, with a housing body which has a plug section which can be fitted together with the mating plug element in a direction of insertion and a conductor receptacle section remote from the plug section with at least one conductor entry opening, and with at least one contact element which has an insertion member which is arranged spaced apart from the at least one conductor entry opening in the plug section and can be fitted together with the mating contact element, and a conductor fastening section for connecting the at least one electrical conductor, characterised in that the conductor fastening section is provided with a plug contact designed as a pin receptacle, wherein a central axis of the pin receptacle is aligned with a central axis of the at least one conductor entry opening in a direction of introduction for the at least one electrical conductor, and a conductor latching element (57, 57') is arranged in the housing body, which element in a projection in the direction of introduction overlaps the at least one conductor entry opening at least in sections, and in that a casing element is provided, which casing element is formed in one piece.
A substrate for adhesion of at least one animal or human cell on the surface of which is generated an adhesion pattern for at least one animal or human cell, said pattern including at least two adhesive areas to said cell which are spaced from each other by a non-adhesive area to said cell on which a non-adhesive polymer to said cell is immobilized, characterized in that the adhesive areas of an adhesive pattern are placed so that the cell may adhere, under adhesion conditions, onto the adhesive areas by forming a bridge over the non-adhesive polymer, the polymer has a conformation which may be modified by changing a parameter of the environment in which the substrate is found and appears as a so-called compacted conformation, under adhesion conditions of the cell, in order to be deployed in a so-called deployed conformation by modification of a parameter of the environment in which the substrate is found.
A dial gauge, comprising: a dial plate having a dial face including angularly spaced markings indicating values; a pointer disposed at a front side of the dial plate and angularly moveable over the dial face with respect to the markings so as to indicate a reading, the pointer being connected to a rotating member disposed below the light guide which defines a rotation axis for rotation of the pointer; an illumination source arranged to emit illumination light and disposed below a central region of the dial plate; and an optical light guide arranged to guide illumination light from below the dial plate to the front side of the dial plate so as to illuminate the dial face from above; characterized in that the optical light guide comprises an annulus portion disposed below the dial plate and radially outwardly extending from a light input proximal to the illumination source which is arranged to receive illumination light, wherein the annulus portion is arranged to radially outwardly distribute illumination light; wherein the light input is formed by a radially inner surface of the annulus portion which defines a central opening; and wherein the illumination source is located within the central opening of the annulus portion and substantially aligned with the rotation axis. a dial plate having a dial face including angularly spaced markings indicating values; a pointer disposed at a front side of the dial plate and angularly moveable over the dial face with respect to the markings so as to indicate a reading, the pointer being connected to a rotating member disposed below the light guide which defines a rotation axis for rotation of the pointer; an illumination source arranged to emit illumination light and disposed below a central region of the dial plate; and an optical light guide arranged to guide illumination light from below the dial plate to the front side of the dial plate so as to illuminate the dial face from above; characterized in that the optical light guide comprises an annulus portion disposed below the dial plate and radially outwardly extending from a light input proximal to the illumination source which is arranged to receive illumination light, wherein the annulus portion is arranged to radially outwardly distribute illumination light; wherein the light input is formed by a radially inner surface of the annulus portion which defines a central opening; and wherein the illumination source is located within the central opening of the annulus portion and substantially aligned with the rotation axis.
A multi-chambered vessel comprising a first chamber, a second chamber and a seal comprising a first member and a second member, wherein the first member and the second member are engageable with one another to form a barrier separating the first chamber and the second chamber, the vessel further comprising an actuator configured to cause the first member and the second member to disengage one another to open a channel between the first chamber and the second chamber, wherein the second member comprises a plug and the first member comprises a seal portion and a through hole, the through hole being configured to receive at least a portion of the plug when the first member and the second member are engaged, and characterised in that the second member comprises a support structure configured to engage an internal wall of the vessel and hold the plug in position relative to the through hole of the first member.
A method of inspecting material laid by a material placement machine on to a substrate to fabricate a composite structure comprising: directing light onto the material in a direction essentially normal to the material to illuminate a section of the material; and projecting laser energy onto the section at an angle predetermined to reveal imperfections in the section, characterized in that: projecting laser energy comprises projecting one or more laser lines onto the section, wherein the one or more laser lines are projected across an axis of placement of the material. directing light onto the material in a direction essentially normal to the material to illuminate a section of the material; and projecting laser energy onto the section at an angle predetermined to reveal imperfections in the section, characterized in that: projecting laser energy comprises projecting one or more laser lines onto the section, wherein the one or more laser lines are projected across an axis of placement of the material. projecting laser energy comprises projecting one or more laser lines onto the section, wherein the one or more laser lines are projected across an axis of placement of the material.
A method for obtaining Retinal Pigment Epithelium cells, comprising: a. providing a culture of human pluripotent stem cells adherent on a first substrate comprising a first laminin; b. exposing the stem cells to a differentiation medium for a first time period of 15 days to 50 days to obtain a first population of adherent cells comprising RPE cells and/or progenitors thereof; c. at the end of the first time period, dissociating the first population from the first substrate; d. replating the dissociated first population of cells on a second substrate comprising a second laminin; and e. culturing the replated first population of cells on the second substrate for second time period to obtain an expanded and matured second population of cells comprising the RPE cells; wherein the first and second laminins are independently selected from LN-521, LN-511, LN-111 and LN-121, and are an intact protein or protein fragment having essentially the same activity as an intact protein; wherein the method comprises quantitating the fraction of cells expressing the marker CD140b; and wherein the dissociation step (c) is initiated when at least 30% of the cells are positive for the marker and/or wherein the culturing step (e) is continued until at least 80% of the cells are positive for the marker. a. providing a culture of human pluripotent stem cells adherent on a first substrate comprising a first laminin; b. exposing the stem cells to a differentiation medium for a first time period of 15 days to 50 days to obtain a first population of adherent cells comprising RPE cells and/or progenitors thereof; c. at the end of the first time period, dissociating the first population from the first substrate; d. replating the dissociated first population of cells on a second substrate comprising a second laminin; and e. culturing the replated first population of cells on the second substrate for second time period to obtain an expanded and matured second population of cells comprising the RPE cells; wherein the first and second laminins are independently selected from LN-521, LN-511, LN-111 and LN-121, and are an intact protein or protein fragment having essentially the same activity as an intact protein; wherein the method comprises quantitating the fraction of cells expressing the marker CD140b; and wherein the dissociation step (c) is initiated when at least 30% of the cells are positive for the marker and/or wherein the culturing step (e) is continued until at least 80% of the cells are positive for the marker.
A fluid transfer assembly, comprising: a fluid container having an opening in a bottom thereof; a coupling device attached to the fluid container at the opening, the coupling device including a valve biasing the coupling device in a closed fluid-tight position via magnetic attraction of opposing first and second components, each of the opposing first and second components including a magnetic material; and a filling device including a rigid member with a perimeter smaller than a perimeter of the fluid container opening, the rigid member including a passage along a longitudinal axis and one or more apertures through a sidewall in fluid communication with the passage, wherein the coupling device is transitioned from the closed fluid-tight position to an open position by pressing the rigid member against one of the opposing first and second components to place the one or more apertures in fluid communication with an interior of the fluid container. a fluid container having an opening in a bottom thereof; a coupling device attached to the fluid container at the opening, the coupling device including a valve biasing the coupling device in a closed fluid-tight position via magnetic attraction of opposing first and second components, each of the opposing first and second components including a magnetic material; and a filling device including a rigid member with a perimeter smaller than a perimeter of the fluid container opening, the rigid member including a passage along a longitudinal axis and one or more apertures through a sidewall in fluid communication with the passage, wherein the coupling device is transitioned from the closed fluid-tight position to an open position by pressing the rigid member against one of the opposing first and second components to place the one or more apertures in fluid communication with an interior of the fluid container.