A compound of Formula: or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, stereoisomer, or tautomer thereof, wherein: R 1 is -OR 5; R 5 is -C 1 -C 6 alkyl; R 6 is phenyl optionally substituted with one or more R 10; R 10 is each independently, at each occurrence,-C 1 -C 6 alkyl, -C2-C6alkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, heterocyclyl, heteroaryl, aryl, -OH, halogen,-NO 2, -CN, -NH 2, -OC 1 -C 6 alkyl, -OC 3 -C 6 cycloalkyl, -Oaryl, -Oheteroaryl, -NHC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl) 2, -S 2 NH(C 1 -C 6 alkyl), -S 2 N(C 1 -C 6 alkyl) 2, -S 2 C 1 -C 6 alkyl, -C C 1 -C 6 alkyl, -C NH 2, -C NH(C 1 -C 6 alkyl), -C N(C 1 -C 6 alkyl) 2, -C OC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, -S (C 1 -C 6 alkyl), -S N(C 1 -C 6 alkyl) 2, or -N(C 1 -C 6 alkyl)S (C 1 -C 6 alkyl), wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, or aryl is optionally substituted with one or more -R 12; wherein any two R 10 when on non-adjacent atoms, can combine to form a bridging cycloalkyl or heterocyclyl; wherein any two R 10 when on adjacent atoms, can combine to form a cycloalkyl, heterocyclyl, aryl or heteroaryl; R 12 is independently, at each occurrence,-C 1 -C 6 alkyl, -C2-C6alkenyl, -C2-C6alkynyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, heterocyclyl, heteroaryl, aryl, -OH, halogen, oxo, -NO 2, -CN, -NH 2, -OC 1 -C 6 alkyl, -NHC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl) 2, -S 2 NH(C 1 -C 6 alkyl), -S 2 N(C 1 -C 6 alkyl) 2, -S 2 C 1 -C 6 alkyl, -C C 1 -C 6 alkyl, -C NH 2, -C NH(C 1 -C 6 alkyl), -C N(C 1 -C 6 alkyl) 2, -C OC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, -S (C 1 -C 6 alkyl), -S N(C 1 -C 6 alkyl) 2, or -N(C 1 -C 6 alkyl)S (C 1 -C 6 alkyl). R 1 is -OR 5; R 5 is -C 1 -C 6 alkyl; R 6 is phenyl optionally substituted with one or more R 10; R 10 is each independently, at each occurrence,-C 1 -C 6 alkyl, -C2-C6alkenyl, -C 2 -C 6 alkynyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, heterocyclyl, heteroaryl, aryl, -OH, halogen,-NO 2, -CN, -NH 2, -OC 1 -C 6 alkyl, -OC 3 -C 6 cycloalkyl, -Oaryl, -Oheteroaryl, -NHC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl) 2, -S 2 NH(C 1 -C 6 alkyl), -S 2 N(C 1 -C 6 alkyl) 2, -S 2 C 1 -C 6 alkyl, -C C 1 -C 6 alkyl, -C NH 2, -C NH(C 1 -C 6 alkyl), -C N(C 1 -C 6 alkyl) 2, -C OC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, -S (C 1 -C 6 alkyl), -S N(C 1 -C 6 alkyl) 2, or -N(C 1 -C 6 alkyl)S (C 1 -C 6 alkyl), wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, heteroaryl, or aryl is optionally substituted with one or more -R 12; wherein any two R 10 when on non-adjacent atoms, can combine to form a bridging cycloalkyl or heterocyclyl; wherein any two R 10 when on adjacent atoms, can combine to form a cycloalkyl, heterocyclyl, aryl or heteroaryl; R 12 is independently, at each occurrence,-C 1 -C 6 alkyl, -C2-C6alkenyl, -C2-C6alkynyl, -C 3 -C 8 cycloalkyl, -C 4 -C 8 cycloalkenyl, heterocyclyl, heteroaryl, aryl, -OH, halogen, oxo, -NO 2, -CN, -NH 2, -OC 1 -C 6 alkyl, -NHC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl) 2, -S 2 NH(C 1 -C 6 alkyl), -S 2 N(C 1 -C 6 alkyl) 2, -S 2 C 1 -C 6 alkyl, -C C 1 -C 6 alkyl, -C NH 2, -C NH(C 1 -C 6 alkyl), -C N(C 1 -C 6 alkyl) 2, -C OC 1 -C 6 alkyl, -N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, -S (C 1 -C 6 alkyl), -S N(C 1 -C 6 alkyl) 2, or -N(C 1 -C 6 alkyl)S (C 1 -C 6 alkyl).