A compound of following general formula: or a pharmaceutically acceptable salt and/or solvate thereof, wherein: • Het is a nitrogen-containing heterocycloalkyl; • X is a single bond, a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkoxy group, in particular a single bond, a (C 1 -C 3)alkyl group or a (C 1 -C 3)alkoxy group; • Y is a group selected from -R 10 C NHR 11; (C 1 -C 6)alkyl; or (C 1 -C 6)alkyl-aryl with (C 1 -C 6)alkyl optionally substituted with =O, =S or a phenyl and with aryl optionally substituted with one or several substituents selected from hydrogen atom, halo,-CN, - NO 2, -OR 12, -NR 13 R 14, -C OR 15, -C NR 16 R 17, -S 2 NR 18 R 19, -S 2 R 20, - NHS 2 R 21, -NHC R 22, or a group selected from (C 1 -C 6)alkyl, aryl, (C 1 -C 6)alkylaryl, heterocycle, (C 1 -C 6)alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, -OR 23 or -OC R 24, or with two adjacent substituents which form together with the carbon atoms to which they are chemically linked an heterocycle; • R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, -NO 2, -CN, -OR 25, -NR 26 R 27, -C OR 28, -S 2 R 29, or a (C 1 -C 6)alkyl group optionally substituted with one or several groups selected from halo or -OR 30; • R 10 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6)alkyl, aryl, (C 1 -C 6)alkyl-aryl, heterocycle, (C 1 -C 6)alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, CF 3 or -OR 31; • R 31 is hydrogen atom, halo or a (C 1 -C 6)alkyl group; for use in the prevention and/or the treatment of acne. • Het is a nitrogen-containing heterocycloalkyl; • X is a single bond, a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkoxy group, in particular a single bond, a (C 1 -C 3)alkyl group or a (C 1 -C 3)alkoxy group; • Y is a group selected from -R 10 C NHR 11; (C 1 -C 6)alkyl; or (C 1 -C 6)alkyl-aryl with (C 1 -C 6)alkyl optionally substituted with =O, =S or a phenyl and with aryl optionally substituted with one or several substituents selected from hydrogen atom, halo,-CN, - NO 2, -OR 12, -NR 13 R 14, -C OR 15, -C NR 16 R 17, -S 2 NR 18 R 19, -S 2 R 20, - NHS 2 R 21, -NHC R 22, or a group selected from (C 1 -C 6)alkyl, aryl, (C 1 -C 6)alkylaryl, heterocycle, (C 1 -C 6)alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, -OR 23 or -OC R 24, or with two adjacent substituents which form together with the carbon atoms to which they are chemically linked an heterocycle; • R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, -NO 2, -CN, -OR 25, -NR 26 R 27, -C OR 28, -S 2 R 29, or a (C 1 -C 6)alkyl group optionally substituted with one or several groups selected from halo or -OR 30; • R 10 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6)alkyl, aryl, (C 1 -C 6)alkyl-aryl, heterocycle, (C 1 -C 6)alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, CF 3 or -OR 31; • R 31 is hydrogen atom, halo or a (C 1 -C 6)alkyl group;