A compound of Formula I: wherein M is CH 2; X is O; Y is CH 2; Z is selected from the group consisting of methylene, 1,1-cyclopropylene, methylmethylene, fluoromethylene, dimethylmethylene, difluoromethylene and fluoromethylmethylene; R 1 is chloro and is in the para position relative to the spiro carbon; R 2 is hydrogen; R 3 is a member selected from the group consisting of hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, (C 3 -C 10)cycloalkyl-(C 1 -C 3)alkyl, C 5 -C 10 cycloalkenyl, (C 5 -C 10)cycloalkenyl-(C 1 -C 3)alkyl, (C 1 -C 4 alkyloxy)C 1 -C 3 alkyl, (C 3 -C 10 cycloalkyloxy)C 1 -C 3 alkyl, (C 1 -C 4 alkylamino)C 1 -C 3 alkyl, di-(C 1 -C 3 alkylamino)C 1 -C 3 alkyl, (C 3 -C 10 cycloalkyl)C 2 -C 4 alkenyl, C 3 -C 6 cycloalkylidenmethyl, aryl, heteroaryl, (C 1 -C 4 alkyl)carbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, (C 1 -C 4 alkyl)aminocarbonyl, di-(C 1 -C 3 alkyl)aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, piperazin-1-ylcarbonyl, 4-(C 1 -C 4 alkyl)piperazin-1-ylcarbonyl, hydroxycarbonyl, (C 1 -C 4 alkyloxy)carbonyl, C 1 -C 4 alkylamino, di-(C 1 -C 3 alkyl)amino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 4-(C 1 -C 4 alkyl)piperazin-1-yl, (C 1 -C 4 alkyl)carbonylamino, arylcarbonylamino, heteroaryl-carbonylamino, C 1 -C 4 alkylsulfonylamino, arylsulfonylamino, C 1 -C 6 alkyloxy, C 3 -C 10 cycloalkyloxy, C 5 -C 7 cycloalkenyloxy, aryloxy, heteroaryloxy, (C 2 -C 4 alkenyl)C 1 -C 3 alkyloxy, (C 2 -C 4 alkynyl)C 1 -C 3 alkyloxy, (aryl)C 1 -C 3 alkyloxy, (heteroaryl)C 1 -C 3 alkyloxy, C 1 -C 4 alkylsulfanyl, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 3 -C 10 cycloalkylsulfanyl, C 3 -C 10 cycloalkylsulfinyl, C 3 -C 10 cycloalkylsulfonyl, C 5 -C 10 cycloalkenylsulfanyl, C 5 -C 10 cycloalkenylsulfinyl, C 5 -C 10 cycloalkenylsulfonyl, arylsulfanyl, arylsulfinyl, arylsulfonyl, amino, hydroxy, cyano or nitro, wherein alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or portions are optionally partly or completely fluorinated and optionally mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, C 1 -C 3 alkoxy and C 1 -C 3 alkyl, and in cycloalkyl and cycloalkenyl groups one or two methylene groups are optionally replaced independently of one another by O, S, CO, SO or SO 2, and in N-heterocycloalkyl groups a methylene group is optionally replaced by CO or SO 2; R 4 and R 5 are each hydrogen; and R 6, R 7, R 8 and R 9 are each hydroxyl; and pharmaceutically acceptable salts thereof. M is CH 2; X is O; Y is CH 2; Z is selected from the group consisting of methylene, 1,1-cyclopropylene, methylmethylene, fluoromethylene, dimethylmethylene, difluoromethylene and fluoromethylmethylene; R 1 is chloro and is in the para position relative to the spiro carbon; R 2 is hydrogen; R 3 is a member selected from the group consisting of hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, (C 3 -C 10)cycloalkyl-(C 1 -C 3)alkyl, C 5 -C 10 cycloalkenyl, (C 5 -C 10)cycloalkenyl-(C 1 -C 3)alkyl, (C 1 -C 4 alkyloxy)C 1 -C 3 alkyl, (C 3 -C 10 cycloalkyloxy)C 1 -C 3 alkyl, (C 1 -C 4 alkylamino)C 1 -C 3 alkyl, di-(C 1 -C 3 alkylamino)C 1 -C 3 alkyl, (C 3 -C 10 cycloalkyl)C 2 -C 4 alkenyl, C 3 -C 6 cycloalkylidenmethyl, aryl, heteroaryl, (C 1 -C 4 alkyl)carbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, (C 1 -C 4 alkyl)aminocarbonyl, di-(C 1 -C 3 alkyl)aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, piperazin-1-ylcarbonyl, 4-(C 1 -C 4 alkyl)piperazin-1-ylcarbonyl, hydroxycarbonyl, (C 1 -C 4 alkyloxy)carbonyl, C 1 -C 4 alkylamino, di-(C 1 -C 3 alkyl)amino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 4-(C 1 -C 4 alkyl)piperazin-1-yl, (C 1 -C 4 alkyl)carbonylamino, arylcarbonylamino, heteroaryl-carbonylamino, C 1 -C 4 alkylsulfonylamino, arylsulfonylamino, C 1 -C 6 alkyloxy, C 3 -C 10 cycloalkyloxy, C 5 -C 7 cycloalkenyloxy, aryloxy, heteroaryloxy, (C 2 -C 4 alkenyl)C 1 -C 3 alkyloxy, (C 2 -C 4 alkynyl)C 1 -C 3 alkyloxy, (aryl)C 1 -C 3 alkyloxy, (heteroaryl)C 1 -C 3 alkyloxy, C 1 -C 4 alkylsulfanyl, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 3 -C 10 cycloalkylsulfanyl, C 3 -C 10 cycloalkylsulfinyl, C 3 -C 10 cycloalkylsulfonyl, C 5 -C 10 cycloalkenylsulfanyl, C 5 -C 10 cycloalkenylsulfinyl, C 5 -C 10 cycloalkenylsulfonyl, arylsulfanyl, arylsulfinyl, arylsulfonyl, amino, hydroxy, cyano or nitro, wherein alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or portions are optionally partly or completely fluorinated and optionally mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, C 1 -C 3 alkoxy and C 1 -C 3 alkyl, and in cycloalkyl and cycloalkenyl groups one or two methylene groups are optionally replaced independently of one another by O, S, CO, SO or SO 2, and in N-heterocycloalkyl groups a methylene group is optionally replaced by CO or SO 2; R 4 and R 5 are each hydrogen; and R 6, R 7, R 8 and R 9 are each hydroxyl; and