An article of footwear comprising: an upper having an internal volume adapted to receive a foot of a wearer; a sole structure secured to the upper, the sole structure including: a chassis plate provided within the upper; a midsole removably secured to the chassis plate via plurality of fasteners extending therebetween, the midsole positioned such that a portion of the upper extends between the chassis plate and the midsole; and an outsole tread element removably attached to a ground facing surface of the midsole; wherein the plurality of fasteners comprise a plurality of threaded fasteners extending between and removably securing the midsole with the chassis plate, wherein: the chassis plate comprises a plurality of threaded anchors; the midsole comprises a plurality of apertures, each aperture corresponding to a different one of the plurality of threaded anchors; wherein the plurality of fasteners comprise a plurality of threaded bolts, each threaded bolt extending through a corresponding one of the plurality of apertures and being threadably engaged with a different one of the plurality of threaded anchors to secure the midsole with the chassis plate; wherein the midsole comprises a mechanical cushioning structure having an upper plate coupled with a lower plate (82, 86, 88), the upper plate including the plurality of apertures through which the plurality of threaded fasteners extend, the lower plate (82, 86, 88) comprising an anterior end portion, a posterior end portion, and a central portion disposed between the anterior end portion and the posterior end portion; and wherein: the central portion of the lower plate (82, 86, 88) is spaced apart from the upper plate; at least one of the anterior end portion or the posterior end portion of the lower plate (82, 86, 88) is secured to the upper plate; and the outsole tread element is secured to the lower plate (82, 86, 88). an upper having an internal volume adapted to receive a foot of a wearer; a sole structure secured to the upper, the sole structure including: a chassis plate provided within the upper; a midsole removably secured to the chassis plate via plurality of fasteners extending therebetween, the midsole positioned such that a portion of the upper extends between the chassis plate and the midsole; and an outsole tread element removably attached to a ground facing surface of the midsole; a chassis plate provided within the upper; a midsole removably secured to the chassis plate via plurality of fasteners extending therebetween, the midsole positioned such that a portion of the upper extends between the chassis plate and the midsole; and an outsole tread element removably attached to a ground facing surface of the midsole; wherein the plurality of fasteners comprise a plurality of threaded fasteners extending between and removably securing the midsole with the chassis plate, wherein: the chassis plate comprises a plurality of threaded anchors; the midsole comprises a plurality of apertures, each aperture corresponding to a different one of the plurality of threaded anchors; wherein the plurality of fasteners comprise a plurality of threaded bolts, each threaded bolt extending through a corresponding one of the plurality of apertures and being threadably engaged with a different one of the plurality of threaded anchors to secure the midsole with the chassis plate; wherein the midsole comprises a mechanical cushioning structure having an upper plate coupled with a lower plate (82, 86, 88), the upper plate including the plurality of apertures through which the plurality of threaded fasteners extend, the lower plate (82, 86, 88) comprising an anterior end portion, a posterior end portion, and a central portion disposed between the anterior end portion and the posterior end portion; and wherein: the central portion of the lower plate (82, 86, 88) is spaced apart from the upper plate; at least one of the anterior end portion or the posterior end portion of the lower plate (82, 86, 88) is secured to the upper plate; and the outsole tread element is secured to the lower plate (82, 86, 88). the chassis plate comprises a plurality of threaded anchors; the midsole comprises a plurality of apertures, each aperture corresponding to a different one of the plurality of threaded anchors; wherein the plurality of fasteners comprise a plurality of threaded bolts, each threaded bolt extending through a corresponding one of the plurality of apertures and being threadably engaged with a different one of the plurality of threaded anchors to secure the midsole with the chassis plate; wherein the midsole comprises a mechanical cushioning structure having an upper plate coupled with a lower plate (82, 86, 88), the upper plate including the plurality of apertures through which the plurality of threaded fasteners extend, the lower plate (82, 86, 88) comprising an anterior end portion, a posterior end portion, and a central portion disposed between the anterior end portion and the posterior end portion; and wherein: the central portion of the lower plate (82, 86, 88) is spaced apart from the upper plate; at least one of the anterior end portion or the posterior end portion of the lower plate (82, 86, 88) is secured to the upper plate; and the outsole tread element is secured to the lower plate (82, 86, 88). the central portion of the lower plate (82, 86, 88) is spaced apart from the upper plate; at least one of the anterior end portion or the posterior end portion of the lower plate (82, 86, 88) is secured to the upper plate; and the outsole tread element is secured to the lower plate (82, 86, 88).