A compound of formula in which R1 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR 8, C (1-6C-alkyl), NHC (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, - C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-cycloalkyl, 3-7C-heterocyclyl, aryl, R2 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR8, C (1-6C-alkyl), NHC (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, -C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-heterocyclyl, aryl, R3 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR8, C (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, NHC (1-6C-alkyl), 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, -C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-heterocyclyl, aryl, R4 is phenyl which is optionally substituted one, two or three times, identically or differently, with a halogen atom; R5 is hydrogen, 1-6C-alkyl, R6 is hydrogen, 1-6C-alkyl, R8 is hydrogen, 1-6C-alkyl which optionally is substituted with hydroxy, R9 is hydrogen, 1-6C-alkyl, R10 is hydrogen, 1-6C-alkyl, R11 is hydrogen, 1-6C-alkyl, X, Y is CH 2; n is 0, 1, 2; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer. R1 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR 8, C (1-6C-alkyl), NHC (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, - C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-cycloalkyl, 3-7C-heterocyclyl, aryl, R2 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR8, C (1-6C-alkyl), NHC (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, -C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-heterocyclyl, aryl, hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, -C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-heterocyclyl, aryl, R3 is hydrogen, hydroxy, NR5R6, halogen, cyano, CO(NR8R9), C OR8, C (1-6C-alkyl), NHS 2 R11, NHC NHR11, -S n -1-6C-alkyl, -S 2 NR5R6 or a group selected from 1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyl, aryl, heteroaryl, -(1-6C-alkyl)-aryl, -(1-6C-alkyl)-heteroaryl, -O-(3-7C-cycloalkyl), -O-aryl, -O-(3-7C-heterocyclyl), -O-heteroaryl, -O-(1-6C-alkyl)-heteroaryl, -O-(1-6C-alkyl)-(3-7C-heterocyclyl), -O-(1-6C-alkyl)-aryl, NHC (1-6C-alkyl), 2-6C-alkenyl, 2-6C-alkynyl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from: hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-6C-alkoxy, -NR8R9, cyano, -C NR8R9, -C OR10, -NHC R11, -NHC NHR11, -NHS 2 R11, 3-7C-heterocyclyl, aryl, R4 is phenyl which is optionally substituted one, two or three times, identically or differently, with a halogen atom; R5 is hydrogen, 1-6C-alkyl, R6 is hydrogen, 1-6C-alkyl, R8 is hydrogen, 1-6C-alkyl which optionally is substituted with hydroxy, R9 is hydrogen, 1-6C-alkyl, R10 is hydrogen, 1-6C-alkyl, R11 is hydrogen, 1-6C-alkyl, X, Y is CH 2; n is 0, 1, 2;