mhurhangee/ep-ind-claims huggingface dataset:
A door leaf being configured and provided for use in a wagon of a mass transportation vehicle, having an outside face, an inside face, a height and a width and comprising an outer door leaf layer (10; 10') at least partially forming the outside face and an inner door leaf layer (11; 11') at least partially forming the inside face, the outer and inner door leaf layers (10, 11; 10', 11') being arranged with respect to one another so as to form an inner space therebetween, characterized in that at least one of the outer and inner door leaf layers (10, 11; 10', 11') substantially extends over the entire height and/or the entire width of the door leaf (1; 1') and is formed in one piece, wherein at least the one of the outer and inner door leaf layers (10, 11; 10', 11') is made by deep-drawing or thermoforming a planar sheet polymer material.
A pharmaceutical composition for use in generating regulatory T cells specific to at least one T cell epitope in a subject for treating or preventing a disease wherein suppression of a specific immune response is beneficial, wherein the composition comprises a nanoparticle, said nanoparticle comprising a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising the at least one T cell epitope associated with the outside of the micelle. a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising the at least one T cell epitope associated with the outside of the micelle.
Laminating apparatus, comprising a first and a second laminating roller (2; 3) that are opposite each other to define a laminating zone extending in width and through which there passes a product (E, S) subjected to a laminating force applied by the rollers and supplied in an advancement direction that is transverse to the width of the laminating zone, said first roller being rotatably mounted on a support connected to a movable element the movement of which causes a variation in the laminating force between said rollers (2; 3), said apparatus comprising a motor that drives the movement of said movable element and programmable electronic motor control means, characterized by said programmable electronic motor control means comprising means for moving said movable element whilst the product (E, S) traverses the laminating zone, making the movable element follow a preset law of motion so as to vary the laminating force whilst the product (E, S) traverses the laminating zone.
An insert for use with an article of footwear adapted to engage a foot, the article of footwear having a sole structure and an upper portion connected to the sole structure, the insert comprising: a flexible polymer insert member adapted to be placed in contact with the sole structure of the article of footwear, the insert member comprising a first layer and a second layer connected together in a layered configuration; and a sensor system comprising a first force sensor connected to the insert member and a port in communication with the first force sensor configured for communication with an electronic device, wherein the insert member has an internal airflow system comprising an air chamber defined between the first and second layers (1466, 1468) and, an air passage defined between the first and second layers (1466, 1468) and extending away from the air chamber, characterised by the air chamber being located at the first force sensor, and a vent hole extending through at least one of the first and second layers (1466, 1468), the air passage being in communication with the vent hole, such that compression of the first force sensor is adapted to cause air to flow from the air chamber through the air passage and through the vent hole to an exterior of the insert. a flexible polymer insert member adapted to be placed in contact with the sole structure of the article of footwear, the insert member comprising a first layer and a second layer connected together in a layered configuration; and a sensor system comprising a first force sensor connected to the insert member and a port in communication with the first force sensor configured for communication with an electronic device, wherein the insert member has an internal airflow system comprising an air chamber defined between the first and second layers (1466, 1468) and, an air passage defined between the first and second layers (1466, 1468) and extending away from the air chamber, characterised by the air chamber being located at the first force sensor, and a vent hole extending through at least one of the first and second layers (1466, 1468), the air passage being in communication with the vent hole, such that compression of the first force sensor is adapted to cause air to flow from the air chamber through the air passage and through the vent hole to an exterior of the insert.
A surgical instrument (200,300) for use with a surgical portal apparatus comprising: an elongate shaft having proximal and distal ends and defining a longitudinal axis; and a dilating member disposed at the distal end of the elongate shaft, the dilating member having a tapered profile and having a substantially blunt distal tip, a cross-section of the dilating member including four vertices (226-226"'; 326-326"'), a profile of the dilating member including one or more concave portions, and an outer surface of the dilating member including at least one atraumatic edge member extending outwardly therefrom and proximally from the tip to a proximal end of the dilating member along a contour of the outer surface, characterized in that the atraumatic edge member extends beyond the proximal end of the dilating member and at least partially along the elongate shaft. an elongate shaft having proximal and distal ends and defining a longitudinal axis; and a dilating member disposed at the distal end of the elongate shaft, the dilating member having a tapered profile and having a substantially blunt distal tip, a cross-section of the dilating member including four vertices (226-226"'; 326-326"'), a profile of the dilating member including one or more concave portions, and an outer surface of the dilating member including at least one atraumatic edge member extending outwardly therefrom and proximally from the tip to a proximal end of the dilating member along a contour of the outer surface, characterized in that the atraumatic edge member extends beyond the proximal end of the dilating member and at least partially along the elongate shaft.
A method amplifying the polymorphic region of the Penta E STR locus comprising: a. contacting a first primer to a sample to be analyzed; b. contacting a second primer to the sample; c. subjecting the nucleic acid sample, the first and the second primers to an amplification reaction, and thereby forming an amplification product, wherein the first primer, the second primer or both the first and second primers are labeled with a fluorophore, d. wherein the first primer and the second primer is within 1,000 base pairs of the closest Penta E repeat and possesses the sequence selected from the list consisting of: SEQ ID NO: 2, 3, 5, 6, 8, 9, CCAGGTGTG, or ACAGGTGTG, wherein the first and second primers do not share the same sequence. a. contacting a first primer to a sample to be analyzed; b. contacting a second primer to the sample; c. subjecting the nucleic acid sample, the first and the second primers to an amplification reaction, and thereby forming an amplification product, wherein the first primer, the second primer or both the first and second primers are labeled with a fluorophore, d. wherein the first primer and the second primer is within 1,000 base pairs of the closest Penta E repeat and possesses the sequence selected from the list consisting of: SEQ ID NO: 2, 3, 5, 6, 8, 9, CCAGGTGTG, or ACAGGTGTG, wherein the first and second primers do not share the same sequence.
A compound of Formula (I-g): or a pharmaceutically acceptable salt thereof; wherein: R1 is selected from (C 1 -C 4 alkyl)-O, spirooxirane, cyano, =O, nitro, (C 1 -C 4 alkyl)C, and HO(C 1 -C 4 alkyl)C; R 2 is =O, H, or OR a, where R a is selected from H, optionally substituted C 1 -C 4 alkyl, or optionally substituted aryl, with the proviso that when R 2 is =O, R 8 is not present; R 3 is H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 2 -C 4 alkenyl, optionally substituted C 2 -C 4 alkynyl, or optionally substituted aryl; R b is methyl; R 8, when present, is H or optionally substituted C 1 -C 4 alkyl; - - - denotes an optional, additional C-C bond, resulting in a C=C bond between C 16 -C 17, with the proviso that when present, the R 1 is not =O or spirooxirane. R1 is selected from (C 1 -C 4 alkyl)-O, spirooxirane, cyano, =O, nitro, (C 1 -C 4 alkyl)C, and HO(C 1 -C 4 alkyl)C; R 2 is =O, H, or OR a, where R a is selected from H, optionally substituted C 1 -C 4 alkyl, or optionally substituted aryl, with the proviso that when R 2 is =O, R 8 is not present; R 3 is H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 2 -C 4 alkenyl, optionally substituted C 2 -C 4 alkynyl, or optionally substituted aryl; R b is methyl; R 8, when present, is H or optionally substituted C 1 -C 4 alkyl; - - - denotes an optional, additional C-C bond, resulting in a C=C bond between C 16 -C 17, with the proviso that when present, the R 1 is not =O or spirooxirane.
A method in a first Access and Mobility Management Function, AMF, node (201, 203, 204, 1100), comprising - receiving Relative Capacity, RC, and one or more identifiers of the first AMF node (201, 203, 204, 1100) from an Operation Administration and Maintenance, OAM, node, which has deployed an AMF set to which the first AMF node (201, 203, 204, 1100) belongs; - receiving,from the OAM node, second information of each of all other AMF nodes (201, 203, 204, 1200) within the AMF set, the second information including Relative Capacity, RC, and one or more identifiers for each one of the other AMFs in the AMF set other than the first AMF node (201, 203, 204, 1100); - determining a backup AMF for at least one of the one or more identifiers of the first AMF (201, 203, 204, 1100) through a weighted round robin algorithm and based on the RC of each AMF in the AMF set; and - publishing an association between the one or more identifiers of the first AMF node and the first AMF (201, 203, 204, 1100) as well as information about the determined backup AMF to a Network Repository Function, NRF, via a Network Function, NF, service Registration procedure. - receiving Relative Capacity, RC, and one or more identifiers of the first AMF node (201, 203, 204, 1100) from an Operation Administration and Maintenance, OAM, node, which has deployed an AMF set to which the first AMF node (201, 203, 204, 1100) belongs; - receiving,from the OAM node, second information of each of all other AMF nodes (201, 203, 204, 1200) within the AMF set, the second information including Relative Capacity, RC, and one or more identifiers for each one of the other AMFs in the AMF set other than the first AMF node (201, 203, 204, 1100); - determining a backup AMF for at least one of the one or more identifiers of the first AMF (201, 203, 204, 1100) through a weighted round robin algorithm and based on the RC of each AMF in the AMF set; and - publishing an association between the one or more identifiers of the first AMF node and the first AMF (201, 203, 204, 1100) as well as information about the determined backup AMF to a Network Repository Function, NRF, via a Network Function, NF, service Registration procedure.
Soft intraocular lens injection device, comprising - a tubular body presenting a casing and an axial cavity, as well as a proximal end and a distal end, - a pushbutton introduced in said axial cavity, at the abovesaid proximal end, and moveable in this cavity along an axial direction, - a barrel arranged at said distal end of the tubular body and presenting an ejection cavity in communication with the axial cavity of the tubular body, this ejection cavity having a transversal cross-section decreasing in the direction opposite the tubular body, and - a housing in the axial cavity of the tubular body intended to receive a storage container containing a soft intraocular lens, characterised in that the casing of the tubular body presents a side opening, which gives access to the outside of said housing, so as to make it possible to introduce the storage container in it, and in that, the abovesaid casing carries, protruding externally, a first rotating fixing means, capable of engaging with a second rotating fixing means provided on the storage container, so as to make it possible, in the engaging position of the two abovesaid rotating fixing means, a rotation of the storage container about an axis of rotation parallel to said axial direction of the axial cavity of the tubular body, between a first position of the storage container where it is outside of the tubular body and a second position of the storage container where it is loaded into the abovesaid housing. - a tubular body presenting a casing and an axial cavity, as well as a proximal end and a distal end, - a pushbutton introduced in said axial cavity, at the abovesaid proximal end, and moveable in this cavity along an axial direction, - a barrel arranged at said distal end of the tubular body and presenting an ejection cavity in communication with the axial cavity of the tubular body, this ejection cavity having a transversal cross-section decreasing in the direction opposite the tubular body, and - a housing in the axial cavity of the tubular body intended to receive a storage container containing a soft intraocular lens, characterised in that the casing of the tubular body presents a side opening, which gives access to the outside of said housing, so as to make it possible to introduce the storage container in it, and in that, the abovesaid casing carries, protruding externally, a first rotating fixing means, capable of engaging with a second rotating fixing means provided on the storage container, so as to make it possible, in the engaging position of the two abovesaid rotating fixing means, a rotation of the storage container about an axis of rotation parallel to said axial direction of the axial cavity of the tubular body, between a first position of the storage container where it is outside of the tubular body and a second position of the storage container where it is loaded into the abovesaid housing.
Method for measuring the global ion concentration of a body fluid, characterized in that it comprises the following steps; - application of a stable DC voltage between first and second electrodes (5, 6) of a cell for measuring the global ion concentration of a body fluid so as to cause electrochemical hydrolysis reactions of the body fluid water to occur at the level of said first and second electrodes (5, 6), - measurement of a hydrolysis current between the two electrodes (5, 6), said hydrolysis current being generated by said electrochemical hydrolysis reactions of water and, - determination of the global ion concentration of the body fluid by comparison with a previously defined calibration curve, in that the measuring cell comprises a fluid channel arranging at least one passage enabling the body fluid to flow from an inlet to an outlet, said fluid channel having an internal cross-section less than or equal to 1.5 mm between the first and second electrodes (5, 6) arranged on said passage, so that the ion concentration of the body fluid is the factor limiting the kinetics of said electrochemical hydrolysis reactions of water, and in that the measuring cell comprises a voltage generator and an electronic measurement circuit connected in series to the first and second electrodes (5, 6). - application of a stable DC voltage between first and second electrodes (5, 6) of a cell for measuring the global ion concentration of a body fluid so as to cause electrochemical hydrolysis reactions of the body fluid water to occur at the level of said first and second electrodes (5, 6), - measurement of a hydrolysis current between the two electrodes (5, 6), said hydrolysis current being generated by said electrochemical hydrolysis reactions of water and, - determination of the global ion concentration of the body fluid by comparison with a previously defined calibration curve, in that the measuring cell comprises a fluid channel arranging at least one passage enabling the body fluid to flow from an inlet to an outlet, said fluid channel having an internal cross-section less than or equal to 1.5 mm between the first and second electrodes (5, 6) arranged on said passage, so that the ion concentration of the body fluid is the factor limiting the kinetics of said electrochemical hydrolysis reactions of water, and in that the measuring cell comprises a voltage generator and an electronic measurement circuit connected in series to the first and second electrodes (5, 6).
A system suitable for delivering a therapeutic agent to a target site, the system comprising: a therapeutic agent; a container holding the therapeutic agent; a pressure source having pressurized fluid, the pressure source in fluid communication with at least a portion of the container; a catheter in fluid communication with the container and having a lumen sized for delivery of the therapeutic agent to a target site, wherein a regulated pressure of the pressurized fluid is between about 0.07 kPa (0.01 psi) to about 700 kPa (100 psi); characterised in that: a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, and a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1. a therapeutic agent; a container holding the therapeutic agent; a pressure source having pressurized fluid, the pressure source in fluid communication with at least a portion of the container; a catheter in fluid communication with the container and having a lumen sized for delivery of the therapeutic agent to a target site, wherein a regulated pressure of the pressurized fluid is between about 0.07 kPa (0.01 psi) to about 700 kPa (100 psi); characterised in that: a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, and a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1. a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, and a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1.
A bolt fastening method for lower links in an internal combustion engine equipped with a multi-link-type piston crank mechanism including upper links, the lower links and control links, wherein each of the lower links which is divided into two parts of a lower link lower and a lower link upper is attached so as to sandwich a corresponding one of crank pins and a pair of bolts of each of the lower links is fastened from directions opposite to each other, and then fixed, the bolt fastening method for the lower links comprising: holding a cylinder block in an inverted position such that a crank case side faces upward; temporarily fitting the lower links of respective cylinder sections, the lower links each of which is connected with a corresponding one of pistons via a corresponding one of the upper links in advance, to the respective crank pins of corresponding ones of cylinder sections in a crankshaft in a state in which each of the pistons is fitted into a corresponding one of cylinders; setting the crankshaft to a state of being lifted to an upper position apart from main bearing parts of bulkheads such that all of a plurality of the crank pins having different phases from each other are each set at a position lifted upward from a reference plane surface along end edges of skirt parts of the cylinder block; and fastening the pair of the bolts of each of the lower links from right and left directions by nut runners in a state in which inclined positions of the lower links of the respective cylinder sections, centering the crank pins, are each held at a position in which heads of the pair of the bolts of each of the lower links are directed to right and left directions. holding a cylinder block in an inverted position such that a crank case side faces upward; temporarily fitting the lower links of respective cylinder sections, the lower links each of which is connected with a corresponding one of pistons via a corresponding one of the upper links in advance, to the respective crank pins of corresponding ones of cylinder sections in a crankshaft in a state in which each of the pistons is fitted into a corresponding one of cylinders; setting the crankshaft to a state of being lifted to an upper position apart from main bearing parts of bulkheads such that all of a plurality of the crank pins having different phases from each other are each set at a position lifted upward from a reference plane surface along end edges of skirt parts of the cylinder block; and fastening the pair of the bolts of each of the lower links from right and left directions by nut runners in a state in which inclined positions of the lower links of the respective cylinder sections, centering the crank pins, are each held at a position in which heads of the pair of the bolts of each of the lower links are directed to right and left directions.