A compound of Formula 1, Formula 2 or Formula 3, wherein A is N or -CR 0 --, where R 0 is hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, aryl, perfluoroaryl, alkylaryl, heteroaryl; or, alkylheteroaryl; X and Y are independently -CH 2 --, -CHR a --, or, - CR a R b --, where R a and R b are independently C 1 -C 6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or, alkylheteroaryl; or, R a and R b together form a chain comprising --(CH 2) j --, --(CHR c) j --, or -(CR c R d) j --, where R c and R d are independently C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where j is 2; 3, 4 or 5; Z is -CR e --, or, -N--, where R e is hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, aryl, alkylaryl, heteroaryl or, alkylheteroaryl; R 1 is hydrogen, C 1 -C 6 linear or branched chain alkyl, aryl, C 1 -C 6 linear or branched chain perfluoroalkyl, alkylaryl, heteroaryl, alkylheteroaryl, C 1 -C 6 linear or branched chain alkoxylcarbonyl, C 1 -C 6 linear or branched chain alkylamino-carbonylamino, C 1 -C 6 linear or branched chain alkyloxycarbonylamino, C 1 -C 6 linear or branched chain alkylcarbonylamino, or, C 1 -C 6 linear or branched chain alkylaminocarbonyl; R 2 is independently hydrogen or C 1 -C 6 linear or branched chain alkyl; R 3 and R 4 are independently hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, C 1 -C 6 linear or branched chain perfluoroalkoxy, halogen, cyano, hydroxyl, amino, carboxy, aryl, heteroaryl, C 1 -C 6 linear or branched chain alkoxylcarbonyl, C 1 -C 6 linear or branched chain alkylamino-carbonylamino, or, C 1 -C 6 linear or branched chain alkylaminocarbonyl; R 5 and R 6 are independently hydrogen or C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, cyano, hydroxyl, amino, carboxy, aryl, heteroaryl, or, R 5 and R 6 together form a chain comprising -(CH 2) k -, --(CHR 7) k --, or -(CR 7a R 7b) k -, where R 7, R 7a, and R 7b are independently C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where k is 2; 3, 4 or 5; R 8 is hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, aryl, aryl substituted with one, two or three fluorine atoms, perfluoroaryl, alkylaryl, heteroaryl; or, alkylheteroaryl; or, R 1 and R 8 together form a chain comprising-(CH 2) m --, --(CHR f) m --, or -(CR f R g) m --, where R f and R g are independently C 1 -C 6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where m is 2; 3, 4 or 5; Rg and R 10 are independently hydrogen or C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, cyano, hydroxyl, amino, carboxy, aryl, heteroaryl, or, R 9 and R 10 together form a chain comprising --(CH 2) p --, -(CHR h) p -, or -(CR h R i) p -, where R h and R i are independently C 1 -C 6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where p is 2; 3, 4 or 5; Q is --CO--, --(CH 2) q --, --(CHR s) q --, or - (CR s R t) q --, where R s and R t are independently C 1 -C 6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof; for use in treating and/or preventing a disorder or condition in a subject, wherein the disorder or condition is selected from the group consisting of benign prostate hyperplasia; cancer; atherosclerosis and its associated diseases; dysmenorrhea; dysspermtogenic sterility; respiratory tract disease; otorhinolaryngologic disease; androgen deprivation therapy; injuries of the central nervous system; an infection; digestive system disease; urologic or male genital disease; dermatological disorder; endocrine disorder; lymphatic disorder; congenital/hereditary or neonatal disease; connective tissue disease; disorder of environmental origin; a mental disorder; a cognitive disorder; liver disease; kidney disease and diabetic nephropathy.