mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition comprising a DBait nucleic acid molecule and a PARP inhibitor, wherein the DBait nucleic acid molecule is a hairpin nucleic acid with a double-stranded DNA stem and a loop and has one of the following formulae: wherein N is a deoxynucleotide, n is an integer from 23 to 195, the underlined N refers to a nucleotide having or not a modified phosphodiester backbone, L' is a linker, C is the molecule facilitating endocytosis selected from a lipophilic molecule or a ligand which targets cell receptor enabling receptor mediated endocytosis, L is a linker, m and p, independently, are an integer being 0 or 1, and wherein the DBait nucleic acid molecule has less than 70% sequence identity to any gene in a human genome.
A blister pack (110, 210, 310) for placing at least one product therein, comprising: a backing (112, 212, 312); and a cover (114, 214, 314) attached to the backing (112, 212, 312), the cover (114, 214, 314) and backing (112, 212, 312) in combination forming at least one sealed cavity for containing the product, the sealed cavity including a dome portion (120, 220) and a base portion (122, 222, 322), at least a section of the base portion (122, 222, 322) extending beyond the dome portion (120, 220) in a first direction (D 1), the dome portion (120, 220) extending beyond an outer peripheral portion of the cover (114, 214, 314) in a second direction (D 2), the second direction (D 2) being perpendicular to the first direction (D 1), characterized in that the blister pack (110, 210, 310) comprises at least one active member (116, 216, 316) including at least one of a desiccant and an oxygen scavenger within at least the base portion (122, 222, 322) of the sealed cavity, wherein at least a first portion of the active member (116, 216, 316) being positioned in the base portion (122, 222, 322) of the cavity and at least a second portion of the active member (116, 216, 316) being positioned in or beneath the dome portion (120, 220) of the cavity. a backing (112, 212, 312); and a cover (114, 214, 314) attached to the backing (112, 212, 312), the cover (114, 214, 314) and backing (112, 212, 312) in combination forming at least one sealed cavity for containing the product, the sealed cavity including a dome portion (120, 220) and a base portion (122, 222, 322), at least a section of the base portion (122, 222, 322) extending beyond the dome portion (120, 220) in a first direction (D 1), the dome portion (120, 220) extending beyond an outer peripheral portion of the cover (114, 214, 314) in a second direction (D 2), the second direction (D 2) being perpendicular to the first direction (D 1), characterized in that the blister pack (110, 210, 310) comprises at least one active member (116, 216, 316) including at least one of a desiccant and an oxygen scavenger within at least the base portion (122, 222, 322) of the sealed cavity, wherein at least a first portion of the active member (116, 216, 316) being positioned in the base portion (122, 222, 322) of the cavity and at least a second portion of the active member (116, 216, 316) being positioned in or beneath the dome portion (120, 220) of the cavity.
A projection system comprising: a dome screen, having a spherical shape and adapted to receive an undeformed spherical target image; a first projector, adapted to provide the undeformed spherical target image; and a processor, coupled to the first projector and configured to generate a first prewarp image according to a target image, a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the first projector and the dome screen, established by using a first camera, and a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the dome screen and a viewing point, established by using the camera; wherein the first projector is configured to project the first prewarp image so as to form the undeformed spherical target image at the viewing point; and characterized in that a distance between a position of the viewing point and a position of a center of a sphere corresponding to the dome screen is at least greater than or equal to a distance of a sphere radius/tan(fov/2) of the dome screen, where fov is a viewing angle of a viewer. a dome screen, having a spherical shape and adapted to receive an undeformed spherical target image; a first projector, adapted to provide the undeformed spherical target image; and a processor, coupled to the first projector and configured to generate a first prewarp image according to a target image, a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the first projector and the dome screen, established by using a first camera, and a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the dome screen and a viewing point, established by using the camera; a target image, a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the first projector and the dome screen, established by using a first camera, and a spatial relationship, comprising at least one of coordinates, relative angles or displacement positions between the dome screen and a viewing point, established by using the camera; wherein the first projector is configured to project the first prewarp image so as to form the undeformed spherical target image at the viewing point; and characterized in that a distance between a position of the viewing point and a position of a center of a sphere corresponding to the dome screen is at least greater than or equal to a distance of a sphere radius/tan(fov/2) of the dome screen, where fov is a viewing angle of a viewer.
Method for the preparation of differentiated nerve cells and glial cells for transplantation into patients in order to treat CNS injury, said method comprising the step of stimulating neural progenitor cells with a composition comprising an IL-6R/IL-6 chimera, ex vivo, wherein the neural progenitor cells are not of human embryonic origin.
A vehicle pedal device including a transmission member (22; 48a) that transmits an operation force applied to a pedal (20; 48), a reaction force lever that is disposed on the transmission member (22; 48a) so that the reaction force lever pivot about a predetermined axis, and that outputs the operation force transmitted to the transmission member (22; 48a) to a brake device against a biasing force of a load spring, and a depressing force detector that is fixedly attached to a pedal arm (20a; 48a) of the pedal (20; 48) or to a sub lever coupled to the pedal arm (20a; 48a) and that receives a reaction force of the reaction force lever to detect the operation force applied to the pedal (20; 48), wherein the depressing force detector has a positioning pin projecting from the depressing force detector, the pedal arm (20a; 48a) of the pedal (20; 48) or the sub lever coupled to the pedal arm (20a; 48a) has a positioning pin insertion hole (22e, 22h) in which the positioning pin of the depressing force detector is inserted, the depressing force detector is fixed to the pedal arm (20a; 48a) or the sub lever with the positioning pin being pressed against an inner peripheral edge of the positioning pin insertion hole (22e, 22h) by a reaction force of the load spring, and the load spring is fixedly positioned between the reaction force lever and the depressing force detector, characterized in that the load spring is a coil spring, and the load spring is placed on an outer periphery side of a detection shaft projecting from the depressing force detector so that the load spring is coaxial with an axis of the detection shaft.
A resin composition comprising a biodegradable 3-hydroxyalkanoate copolymer and a plasticizer, wherein: the biodegradable 3-hydroxyalkanoate copolymer has a recurring unit represented by the structure formula: [-CHR-CH 2 -CO-O-] (wherein, R represents an alkyl group represented by C n H 2n+1; and n is an integer of 1 to 15) and is constituted with poly[3-hydroxybutyrate-co-3-hydroxyhexanoate] having a recurring unit of 3-hydroxybutyrate and a recurring unit of 3-hydroxyhexanoate as principal components, the plasticizer is constituted with 100 to 50% by weight of a polyglycerol acetic acid ester having an acetylation degree of no less than 50%, and 0 to 50% by weight of a monoglycerol ester; and the resin composition comprises 0.1 to 50 parts by weight of the plasticizer based on 100 parts by weight of the copolymer.
A detection system comprising: at least one sensor configured to measure a presence of airborne particles, wherein the at least one sensor comprises a nanofiber chemical sensor for sensing a chemical composition of the airborne particles, and wherein the nanofiber chemical sensor comprises a variable resistance that varies in response to a concentration of the chemical composition of the airborne particles; at least one amplifier circuit in communication with the at least one sensor, wherein the amplifier circuit is configured to monitor a charge generated by the at least one sensor over a time interval; and a controller configured to: monitor the charge accumulated in the at least one amplifier circuit from the at least one sensor at the time interval; and in response to the charge of the at least one amplifier circuit, detect the presence of the airborne particles, wherein the controller is further configured to: detect the concentration of the chemical composition in response to identifying changes in the variable resistance, wherein the changes in the variable resistance are determined based on the charge of the at least one amplifier circuit and a voltage potential of a bias voltage supplied to the at least one nanofiber chemical sensor. at least one sensor configured to measure a presence of airborne particles, wherein the at least one sensor comprises a nanofiber chemical sensor for sensing a chemical composition of the airborne particles, and wherein the nanofiber chemical sensor comprises a variable resistance that varies in response to a concentration of the chemical composition of the airborne particles; wherein the at least one sensor comprises a nanofiber chemical sensor for sensing a chemical composition of the airborne particles, and wherein the nanofiber chemical sensor comprises a variable resistance that varies in response to a concentration of the chemical composition of the airborne particles; at least one amplifier circuit in communication with the at least one sensor, wherein the amplifier circuit is configured to monitor a charge generated by the at least one sensor over a time interval; and a controller configured to: monitor the charge accumulated in the at least one amplifier circuit from the at least one sensor at the time interval; and in response to the charge of the at least one amplifier circuit, detect the presence of the airborne particles, monitor the charge accumulated in the at least one amplifier circuit from the at least one sensor at the time interval; and in response to the charge of the at least one amplifier circuit, detect the presence of the airborne particles, wherein the controller is further configured to: detect the concentration of the chemical composition in response to identifying changes in the variable resistance, wherein the changes in the variable resistance are determined based on the charge of the at least one amplifier circuit and a voltage potential of a bias voltage supplied to the at least one nanofiber chemical sensor.
A building panel for a wall or ceiling comprising: a first plate forming a front of the panel; a second plate forming a rear of the panel; a core structure positioned between the first plate and the second plate and being adhesively bonded to the first plate and the second plate; an attachment member for attaching the panel to a wall or ceiling or to a structure attached to a wall or ceiling; and a mechanical fastener which extends between and mechanically fastens the first plate to the attachment member; characterised in that the attachment member is provided with a recess, hole or groove for receiving the mechanical fastener, and the recess, hole or groove provided in the attachment member extends along the longitudinal direction of the attachment member. a first plate forming a front of the panel; a second plate forming a rear of the panel; a core structure positioned between the first plate and the second plate and being adhesively bonded to the first plate and the second plate; an attachment member for attaching the panel to a wall or ceiling or to a structure attached to a wall or ceiling; and a mechanical fastener which extends between and mechanically fastens the first plate to the attachment member; characterised in that the attachment member is provided with a recess, hole or groove for receiving the mechanical fastener, and the recess, hole or groove provided in the attachment member extends along the longitudinal direction of the attachment member.
A device for attracting attention, characterised in that it comprises a mounting means (1; 101) and a disc (7; 107) disposed for rotation on the mounting means (1; 101), that reflectors or luminous means (10; 110) are attached to at least one side of the disc (7; 107), that the centre of gravity of the disc (7; 107) is displaced from the centre of the disc (7; 107), and that in a position of rest of the disc (7; 107) the reflectors or luminous means (10; 110) are masked by the mounting means (1; 101) when the device is observed in plan view.
A dispenser for dispensing a metered amount of a substance, the dispenser comprising a first housing member defining a handle for the dispenser; a substance containing chamber arranged to slide telescopically with respect to the handle, the substance containing chamber having a nozzle opening at a first axial end, from which substance is, in use, dispensed; the substance containing chamber including a bearing axially fixed at the second axial end of the substance containing chamber; a shaft rotatably fixed with respect to the handle and arranged to pass through the bearing such that upon rotation of the handle with respect to the substance containing chamber, the substance containing chamber and the handle move telescopically with respect to each other such that, the substance containing chamber moves axially within the handle to force substance through the nozzle opening, wherein movement of the handle with respect to the substance containing chamber is indexed so as to dispense a predetermined volume of substance in dependence on a rotation thereof. a first housing member defining a handle for the dispenser; a substance containing chamber arranged to slide telescopically with respect to the handle, the substance containing chamber having a nozzle opening at a first axial end, from which substance is, in use, dispensed; the substance containing chamber including a bearing axially fixed at the second axial end of the substance containing chamber; a shaft rotatably fixed with respect to the handle and arranged to pass through the bearing such that upon rotation of the handle with respect to the substance containing chamber, the substance containing chamber and the handle move telescopically with respect to each other such that, the substance containing chamber moves axially within the handle to force substance through the nozzle opening, wherein movement of the handle with respect to the substance containing chamber is indexed so as to dispense a predetermined volume of substance in dependence on a rotation thereof.
An inflation device for selectively inflating a balloon of surgical instrument, the device comprising: a syringe including a plunger slidably disposed within a barrel; a connector for fluidly connecting an outlet of the syringe with a surgical instrument balloon to establish a closed inflation system between the syringe and an interior of the balloon; a mechanical pressure indicator associated with the syringe and configured to transition from a non-alert state to an alert state when a pressure of the inflation system has reached a predetermined level; characterised by; the pressure indicator includes a housing disposed about a portion of the barrel; and a spring disposed between an end of the barrel and the housing; wherein the pressure indicator is configured such that the end of the barrel disengages from the housing once a pressure of the inflation system exceeds a biasing force of the spring. a syringe including a plunger slidably disposed within a barrel; a connector for fluidly connecting an outlet of the syringe with a surgical instrument balloon to establish a closed inflation system between the syringe and an interior of the balloon; a mechanical pressure indicator associated with the syringe and configured to transition from a non-alert state to an alert state when a pressure of the inflation system has reached a predetermined level; characterised by; the pressure indicator includes a housing disposed about a portion of the barrel; and a spring disposed between an end of the barrel and the housing; wherein the pressure indicator is configured such that the end of the barrel disengages from the housing once a pressure of the inflation system exceeds a biasing force of the spring. a housing disposed about a portion of the barrel; and a spring disposed between an end of the barrel and the housing; wherein the pressure indicator is configured such that the end of the barrel disengages from the housing once a pressure of the inflation system exceeds a biasing force of the spring.
A key for a cylinder lock, comprising at least one encoded lateral surface (3, 3'), which extends along the longitudinal direction of the key, a. wherein at least one code to be read in the cylinder lock is provided on the lateral surface (3, 3'), b. wherein the code comprises a first reading surface, which extends in the longitudinal direction of the key, and a second reading surface, which extends in the longitudinal direction of the key, c. wherein the reading surfaces (5, 5') are arranged offset from one another in a transverse direction (6, 6') of the key, wherein d. the reading surfaces (5, 5') are arranged offset from one another in the longitudinal direction, and e. their respective cross-sections have the shape of a steady and preferably periodical curve, characterised in that the curves are designed as sine curves or cosine curves, preferably over at least an entire period length. a. wherein at least one code to be read in the cylinder lock is provided on the lateral surface (3, 3'), b. wherein the code comprises a first reading surface, which extends in the longitudinal direction of the key, and a second reading surface, which extends in the longitudinal direction of the key, c. wherein the reading surfaces (5, 5') are arranged offset from one another in a transverse direction (6, 6') of the key, wherein d. the reading surfaces (5, 5') are arranged offset from one another in the longitudinal direction, and e. their respective cross-sections have the shape of a steady and preferably periodical curve,
Process for the production of prefoamed poly(meth)acrylimide (P I) particles that can be used for in-mould foaming, characterized in that unfoamed P I particles are prefoamed by infrared radiation, at least 80% of which has a wavelength of from 1.4 to 10.0 μm.
An induction heating cooktop with at least one double-coil heater having concentrically disposed induction coils in the form of inner and outer ring induction coils (9, 10) and a power circuit for powering said double-coil heater, said power circuit comprising a rectifier rectifying the alternative signal, filter circuits (F1, F2) and inverter stages (S1, S2) associated with said inner and outer ring induction coils (9, 10), each inverter stage (S1, S2) comprising a respective inner and outer ring switching devices (7, 8) in parallel with a reverse-biased freewheeling diode, said inner and outer ring switching devices (7, 8) being triggered by a respective gate drive circuit (G1, G2) in electrical communication with two output pins of a microcontroller characterized in that - said gate drive circuits (G1, G2) of the inner and outer ring switching devices (7, 8) are configured to trigger the same while the microcontroller's respective output pins remain in a low logic state, - the two output pins of the microcontroller are connected through a diode such that said inner and outer ring induction coils (9, 10) are simultaneously powered only when said diode is forward-biased in response to the transition of the output pin of the microcontroller associated with the outer ring induction coil to the high-impedance mode, - the output pin of the microcontroller associated with said outer ring induction coil is connected to a positive supply voltage (Vcc) through a pull-up resistor. - said gate drive circuits (G1, G2) of the inner and outer ring switching devices (7, 8) are configured to trigger the same while the microcontroller's respective output pins remain in a low logic state, - the two output pins of the microcontroller are connected through a diode such that said inner and outer ring induction coils (9, 10) are simultaneously powered only when said diode is forward-biased in response to the transition of the output pin of the microcontroller associated with the outer ring induction coil to the high-impedance mode, - the output pin of the microcontroller associated with said outer ring induction coil is connected to a positive supply voltage (Vcc) through a pull-up resistor.