A distillation system using multi-stage stripper capable of integrated operation and reduction of steam consumption, the distillation system configured to separate mixed material existing in a feedstock material into high volatile components and low volatile components based on difference of boiling point, the system comprising: a stripper module including a plurality of strippers (111, 112), and configured to receive the feedstock material, evaporate and discharge the high volatile component as overhead vapor and configured to separate the low volatile component as un-distilled in a lower portion of the stripper; a condense-evaporator configured to condense the overhead vapor that passed through the stripper module and to evaporate water supplied from a source of water supply by heat exchanging the overhead vapor with the water;a mechanical vapor recompression module that compresses water vapor evaporated in the condense-evaporator by multi-stages; and a steam supplier that supplies steam to the plurality of strippers (111, 112), wherein the mechanical vapor recompression module is arranged to supply the water vapor compressed in the mechanical vapor recompression module to at least two strippers (111, 112); wherein the stripper module comprises: a first stripper configured to receive the feedstock material, evaporate the high volatile component, and discharge the evaporated high volatile component as the overhead vapor, and configured to separate the low volatile component as un-distilled in the lower portion of the first stripper; and a second stripper configured to operate at a higher temperature than the first stripper, receive material that is not evaporated in the first stripper, strip the high volatile component, discharge the stripped high volatile component as the overhead vapor, and configured to separate the low volatile component as un-distilled in the lower portion of the second stripper, characterized in that the plurality of strippers (111, 112) is operable such that gas-liquid equilibrium pressure and temperature of the high volatile component being evaporated in each of the strippers (111, 112) are different from each other; and the mechanical vapor recompression module is arranged such that a portion of the water vapor compressed in the mechanical vapor recompression module is preferentially supplied to the second stripper and the rest of the water vapor is supplied to the first stripper. a stripper module including a plurality of strippers (111, 112), and configured to receive the feedstock material, evaporate and discharge the high volatile component as overhead vapor and configured to separate the low volatile component as un-distilled in a lower portion of the stripper; a condense-evaporator configured to condense the overhead vapor that passed through the stripper module and to evaporate water supplied from a source of water supply by heat exchanging the overhead vapor with the water;a mechanical vapor recompression module that compresses water vapor evaporated in the condense-evaporator by multi-stages; and a steam supplier that supplies steam to the plurality of strippers (111, 112), wherein the mechanical vapor recompression module is arranged to supply the water vapor compressed in the mechanical vapor recompression module to at least two strippers (111, 112); wherein the stripper module comprises: a first stripper configured to receive the feedstock material, evaporate the high volatile component, and discharge the evaporated high volatile component as the overhead vapor, and configured to separate the low volatile component as un-distilled in the lower portion of the first stripper; and a second stripper configured to operate at a higher temperature than the first stripper, receive material that is not evaporated in the first stripper, strip the high volatile component, discharge the stripped high volatile component as the overhead vapor, and configured to separate the low volatile component as un-distilled in the lower portion of the second stripper, characterized in that the plurality of strippers (111, 112) is operable such that gas-liquid equilibrium pressure and temperature of the high volatile component being evaporated in each of the strippers (111, 112) are different from each other; and the mechanical vapor recompression module is arranged such that a portion of the water vapor compressed in the mechanical vapor recompression module is preferentially supplied to the second stripper and the rest of the water vapor is supplied to the first stripper.