A liquid handling system, comprising: a liquid handling device having a plurality of pipetting heads; a tip box having a periphery and a plurality of tips configured for removable attachment to the pipetting heads; and a lever mechanism configured to engage the liquid handling device and the tip box during a process of moving the liquid handling device along a central axis in the direction of the tip box for attachment of the tips to the pipetting heads, the lever mechanism including: a first lever arm attached to one of the liquid handling device or the tip box at a first fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a first hinge attached to the one of the liquid handling device or the tip box, and terminating in a first arm end; and a second lever arm attached to the one of the liquid handling device or the tip box at a second fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a second hinge attached to the one of the liquid handling device or the tip box, and terminating in a second arm end; wherein the lever mechanism is configured to receive a force from the liquid handling device proximate the first fulcrum and the second fulcrum, the first lever arm end and second lever arm end configured to engage the periphery of the tip box in response to the first lever arm extending from the first fulcrum and rotating around the first hinge, and the second lever arm extending from the second fulcrum and rotating around the second hinge, to thereby apply an opposite force to urge the tip box and liquid handling device together. a liquid handling device having a plurality of pipetting heads; a tip box having a periphery and a plurality of tips configured for removable attachment to the pipetting heads; and a lever mechanism configured to engage the liquid handling device and the tip box during a process of moving the liquid handling device along a central axis in the direction of the tip box for attachment of the tips to the pipetting heads, the lever mechanism including: a first lever arm attached to one of the liquid handling device or the tip box at a first fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a first hinge attached to the one of the liquid handling device or the tip box, and terminating in a first arm end; and a second lever arm attached to the one of the liquid handling device or the tip box at a second fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a second hinge attached to the one of the liquid handling device or the tip box, and terminating in a second arm end; a first lever arm attached to one of the liquid handling device or the tip box at a first fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a first hinge attached to the one of the liquid handling device or the tip box, and terminating in a first arm end; and a second lever arm attached to the one of the liquid handling device or the tip box at a second fulcrum proximate the central axis, extending outwardly from the central axis to rotate around a second hinge attached to the one of the liquid handling device or the tip box, and terminating in a second arm end; wherein the lever mechanism is configured to receive a force from the liquid handling device proximate the first fulcrum and the second fulcrum, the first lever arm end and second lever arm end configured to engage the periphery of the tip box in response to the first lever arm extending from the first fulcrum and rotating around the first hinge, and the second lever arm extending from the second fulcrum and rotating around the second hinge, to thereby apply an opposite force to urge the tip box and liquid handling device together.