An industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium -3-carboxyacrylate salt of following formula: comprising the following successive synthetic steps performed in degassed organic polar or apolar, protic or aprotic solvents: 1) Preparing compound of following formula with an enantiomeric excess higher than 95% by 1a) Reacting compound of following formula With 0.5 - 0.6 molar equivalents of quinine in organic polar and aprotic solvents, preferably in ethyl acetate; 1b) Crystallizing the resulting quinine salt at temperature ranging from 10°C to 20°C, in same organic solvent than the one used in step 1a, wherein crystallization is initiated by adding few crystals of the desired enantiomer salt to initiate the crystallization, then; 1c) Recrystallizing the salt obtained after step 1b at the same temperature range and same solvent than the one used in step 1b; 1d) Recovering of compound by: 1d.1) recovering compound of following formula 1d.2) deprotecting thiolacetate in polar and protic solvent such as MeOH; 1e) Recovering of quinine; 2) Preparing compound of following formula By 2a) Reacting first 1.1 molar equivalents of said compound with 1 molar equivalent of chlorocarbonyl sulfenyl chloride, in polar and aprotic solvent, then; 2b) Reacting the intermediate obtained after step 2a with 0.9 molar equivalents of compound of following formula In solution with 1 molar equivalent of Et 3 N in same solvent than the one used in step 2a; 3) Preparing compound of following formula By Reacting said compound with amino-ester C of following formula, wherein Y - is an anion: In polar solvent; 4) Then, recovering salt of followed formula By 4a) adding 5 molar equivalent of formic acid on said compound; 4b) exchanging the formate by a fumarate using a continuous flow technology. 1) Preparing compound of following formula with an enantiomeric excess higher than 95% by 1a) Reacting compound of following formula With 0.5 - 0.6 molar equivalents of quinine in organic polar and aprotic solvents, preferably in ethyl acetate; 1b) Crystallizing the resulting quinine salt at temperature ranging from 10°C to 20°C, in same organic solvent than the one used in step 1a, wherein crystallization is initiated by adding few crystals of the desired enantiomer salt to initiate the crystallization, then; 1c) Recrystallizing the salt obtained after step 1b at the same temperature range and same solvent than the one used in step 1b; 1d) Recovering of compound by: 1d.1) recovering compound of following formula 1d.2) deprotecting thiolacetate in polar and protic solvent such as MeOH; 1e) Recovering of quinine; 1a) Reacting compound of following formula With 0.5 - 0.6 molar equivalents of quinine in organic polar and aprotic solvents, preferably in ethyl acetate; 1b) Crystallizing the resulting quinine salt at temperature ranging from 10°C to 20°C, in same organic solvent than the one used in step 1a, wherein crystallization is initiated by adding few crystals of the desired enantiomer salt to initiate the crystallization, then; 1c) Recrystallizing the salt obtained after step 1b at the same temperature range and same solvent than the one used in step 1b; 1d) Recovering of compound by: 1d.1) recovering compound of following formula 1d.2) deprotecting thiolacetate in polar and protic solvent such as MeOH; 1d.1) recovering compound of following formula 1d.2) deprotecting thiolacetate in polar and protic solvent such as MeOH; 1e) Recovering of quinine; 2) Preparing compound of following formula By 2a) Reacting first 1.1 molar equivalents of said compound with 1 molar equivalent of chlorocarbonyl sulfenyl chloride, in polar and aprotic solvent, then; 2b) Reacting the intermediate obtained after step 2a with 0.9 molar equivalents of compound of following formula In solution with 1 molar equivalent of Et 3 N in same solvent than the one used in step 2a; 2a) Reacting first 1.1 molar equivalents of said compound with 1 molar equivalent of chlorocarbonyl sulfenyl chloride, in polar and aprotic solvent, then; 2b) Reacting the intermediate obtained after step 2a with 0.9 molar equivalents of compound of following formula In solution with 1 molar equivalent of Et 3 N in same solvent than the one used in step 2a; 3) Preparing compound of following formula By Reacting said compound with amino-ester C of following formula, wherein Y - is an anion: In polar solvent; 4) Then, recovering salt of followed formula By 4a) adding 5 molar equivalent of formic acid on said compound; 4b) exchanging the formate by a fumarate using a continuous flow technology. 4a) adding 5 molar equivalent of formic acid on said compound; 4b) exchanging the formate by a fumarate using a continuous flow technology.