A curable antimicrobial coating composition comprising: (a) a polymeric matrix which comprises at least one polyurethane prepolymer, wherein said polyurethane prepolymer comprises a polyurethane backbone comprising at least one functional group capable of forming a chemical bond with the below-defined functional group of the long chain cationic surfactant, either directly or through a crosslinker, upon drying or curing of said coating composition; (b) a carrier solvent; (c) at least one long chain cationic surfactant compound comprising a functional group capable of forming a chemical bond with said polyurethane prepolymer upon evaporating said carrier solvent and drying or curing of said composition, said functional group being selected from the group consisting of an amine, thiol, carboxyl, aldehyde, hydroxyl and combinations thereof; and (d) at least one hydrophilic organic monomer, oligomer, prepolymer, polymer or copolymer derived from vinyl alcohol, N-vinylpyrrolidone, N-vinyl lactam, acrylamide, amide, styrenesulfonic acid, combination of vinylbutyral and N-vinylpyrrolidone, hydroxyethyl methacrylate, acrylic acid, vinylmethyl ether, vinylpyridylium halide, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl ethyl cellulose, hydroxypropylmethyl cellulose, cellulose acetate, cellulose nitrate, starch, gelatin, albumin, casein, gum, alginate, hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, ethylene glycol (meth)acrylates (e.g. triethylene glycol (meth)acrylate) and meth)acrylamide), N-alkyl (meth) acrylamides (e.g. N-methyl (meth)acrylamide and N-hexyl (meth)acrylamide), N,N-dialkyl (meth)acrylamides (e.g. N,N-dimethyl (meth)acrylamide and poly-N,N-dipropyl (meth)acrylamide), N-hydroxyalkyl (meth)acrylamide polymers, such as poly-N-methylol (meth)acrylamide and poly-N-hydroxy ethyl (meth)acrylamide, and N,N-dihydroxyalkyl (meth)acrylamide polymers, such as poly-N,N-dihydroxyethyl (meth)acrylamide, ether polyols, polyethylene oxide, polypropylene oxide, and poly(vinyl ether), alkylvinyl sulfones, alkylvinylsulfone-acrylates or a combination thereof; wherein said at least one long chain cationic surfactant compound is non-leaching upon drying or curing of said coating composition and projects at least 15Å away from the surface of the cured coating composition to thereby protrude through and beyond organic debris deposited over time on the surface of said cured composition, wherein said organic debris are dead microbial cells, proteinaceous buildup or a combination thereof. (a) a polymeric matrix which comprises at least one polyurethane prepolymer, wherein said polyurethane prepolymer comprises a polyurethane backbone comprising at least one functional group capable of forming a chemical bond with the below-defined functional group of the long chain cationic surfactant, either directly or through a crosslinker, upon drying or curing of said coating composition; (b) a carrier solvent; (c) at least one long chain cationic surfactant compound comprising a functional group capable of forming a chemical bond with said polyurethane prepolymer upon evaporating said carrier solvent and drying or curing of said composition, said functional group being selected from the group consisting of an amine, thiol, carboxyl, aldehyde, hydroxyl and combinations thereof; and (d) at least one hydrophilic organic monomer, oligomer, prepolymer, polymer or copolymer derived from vinyl alcohol, N-vinylpyrrolidone, N-vinyl lactam, acrylamide, amide, styrenesulfonic acid, combination of vinylbutyral and N-vinylpyrrolidone, hydroxyethyl methacrylate, acrylic acid, vinylmethyl ether, vinylpyridylium halide, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl ethyl cellulose, hydroxypropylmethyl cellulose, cellulose acetate, cellulose nitrate, starch, gelatin, albumin, casein, gum, alginate, hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, ethylene glycol (meth)acrylates (e.g. triethylene glycol (meth)acrylate) and meth)acrylamide), N-alkyl (meth) acrylamides (e.g. N-methyl (meth)acrylamide and N-hexyl (meth)acrylamide), N,N-dialkyl (meth)acrylamides (e.g. N,N-dimethyl (meth)acrylamide and poly-N,N-dipropyl (meth)acrylamide), N-hydroxyalkyl (meth)acrylamide polymers, such as poly-N-methylol (meth)acrylamide and poly-N-hydroxy ethyl (meth)acrylamide, and N,N-dihydroxyalkyl (meth)acrylamide polymers, such as poly-N,N-dihydroxyethyl (meth)acrylamide, ether polyols, polyethylene oxide, polypropylene oxide, and poly(vinyl ether), alkylvinyl sulfones, alkylvinylsulfone-acrylates or a combination thereof; wherein said at least one long chain cationic surfactant compound is non-leaching upon drying or curing of said coating composition and projects at least 15Å away from the surface of the cured coating composition to thereby protrude through and beyond organic debris deposited over time on the surface of said cured composition, wherein said organic debris are dead microbial cells, proteinaceous buildup or a combination thereof.