An isolation and purification method of a perfluoropolyether compound, wherein said method is a method for isolating and purifying a perfluoropolyether compound which has at molecular chain ends thereof only groups that are nonreactive with primary amino groups, wherein the groups that are nonreactive with primary amino groups are groups selected from a hydroxyl group, an alkenyl group, an amino group, a thiol group, and a halogenated alkyl group with a part of or all hydrogen atoms being substituted with halogen atoms, and wherein said method comprises: preparing: a perfluoropolyether compound having, at molecular chain ends thereof, only groups that are nonreactive with primary amino groups, wherein the groups in the component that are nonreactive with primary amino groups are groups selected from a hydroxyl group, an alkenyl group, an amino group, a thiol group, and a halogenated alkyl group with a part of or all hydrogen atoms being substituted with halogen atoms, and having a number average molecular weight of 1,000 to 10,000, a perfluoropolyether compound having, at one or both molecular chain ends thereof, groups that are reactive with or are capable of forming salts with primary amino groups, and having a number average molecular weight of 1,000 to 10,000, and a primary amino group-containing solid adsorbent; wherein the number average molecular weight of a perfluoropolyether compound (polyfluorooxyalkylene compound) refers to a number average molecular weight measured as specified in the description, bringing the primary amino group-containing solid adsorbent into contact with a mixture containing the perfluoropolyether compound and the perfluoropolyether compound; and then removing the perfluoropolyether compound that has been adsorbed to the solid adsorbent. wherein said method is a method for isolating and purifying a perfluoropolyether compound which has at molecular chain ends thereof only groups that are nonreactive with primary amino groups, wherein the groups that are nonreactive with primary amino groups are groups selected from a hydroxyl group, an alkenyl group, an amino group, a thiol group, and a halogenated alkyl group with a part of or all hydrogen atoms being substituted with halogen atoms, and wherein said method comprises: preparing: a perfluoropolyether compound having, at molecular chain ends thereof, only groups that are nonreactive with primary amino groups, wherein the groups in the component that are nonreactive with primary amino groups are groups selected from a hydroxyl group, an alkenyl group, an amino group, a thiol group, and a halogenated alkyl group with a part of or all hydrogen atoms being substituted with halogen atoms, and having a number average molecular weight of 1,000 to 10,000, a perfluoropolyether compound having, at one or both molecular chain ends thereof, groups that are reactive with or are capable of forming salts with primary amino groups, and having a number average molecular weight of 1,000 to 10,000, and a primary amino group-containing solid adsorbent; wherein the number average molecular weight of a perfluoropolyether compound (polyfluorooxyalkylene compound) refers to a number average molecular weight measured as specified in the description, bringing the primary amino group-containing solid adsorbent into contact with a mixture containing the perfluoropolyether compound and the perfluoropolyether compound; and then removing the perfluoropolyether compound that has been adsorbed to the solid adsorbent. a perfluoropolyether compound having, at molecular chain ends thereof, only groups that are nonreactive with primary amino groups, wherein the groups in the component that are nonreactive with primary amino groups are groups selected from a hydroxyl group, an alkenyl group, an amino group, a thiol group, and a halogenated alkyl group with a part of or all hydrogen atoms being substituted with halogen atoms, and having a number average molecular weight of 1,000 to 10,000, a perfluoropolyether compound having, at one or both molecular chain ends thereof, groups that are reactive with or are capable of forming salts with primary amino groups, and having a number average molecular weight of 1,000 to 10,000, and a primary amino group-containing solid adsorbent; wherein the number average molecular weight of a perfluoropolyether compound (polyfluorooxyalkylene compound) refers to a number average molecular weight measured as specified in the description, bringing the primary amino group-containing solid adsorbent into contact with a mixture containing the perfluoropolyether compound and the perfluoropolyether compound; and then removing the perfluoropolyether compound that has been adsorbed to the solid adsorbent. wherein the number average molecular weight of a perfluoropolyether compound (polyfluorooxyalkylene compound) refers to a number average molecular weight measured as specified in the description, bringing the primary amino group-containing solid adsorbent into contact with a mixture containing the perfluoropolyether compound and the perfluoropolyether compound; and then removing the perfluoropolyether compound that has been adsorbed to the solid adsorbent.