A compound of Formula, or a pharmaceutically acceptable salt thereof, having the structure: wherein: B 1 is selected from the group consisting of an optionally substituted and an optionally substituted R 1 is selected from the group consisting of an optionally substituted C 1-6 alkyl, an optionally substituted C 2-6 alkenyl, an optionally substituted C 2-6 alkynyl and an optionally substituted C 3-6 cycloalkyl; each -------- is absent and R p is absent; R 2 is halo, N 3, -OR 7A or -N(R 7B R 7C); R 3 is -OH or -OC(=O)R 8; or R 2 and R 3 are each an oxygen atom which are linked together by a carbonyl group; R 4 is hydrogen or R 5A is selected from the group consisting of O -, OH, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester, and R 5B is selected from the group consisting of O -, OH, an -O-optionally substituted aryl, an -O-optionally substituted heteroaryl, an -O-optionally substituted heterocyclyl, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester, R 6B and R 6C are independently selected from the group consisting of hydrogen, an unsubstituted C 1-6 alkyl, an unsubstituted C 3-6 alkenyl, an unsubstituted C 3-6 alkynyl and an unsubstituted C 3-6 cycloalkyl; R 7A is hydrogen or -C(=O)R 12; R 7B and R 7C are independently hydrogen or an optionally substituted C 1-6 alkyl; R 8 and R 12 are independently an optionally substituted C 1-6 alkyl or an optionally substituted C 3-6 cycloalkyl; R 9, R 10 and R 11 are independently absent or hydrogen; R 8A, R 9A, R 11A, R 12A, R 8B, R 9B, R 11B and R 12B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl and an optionally substituted aryl; R 10A, R 10B, R 13A and R 13B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl, an optionally substituted aryl, an optionally substituted -O-C 1-24 alkyl, an optionally substituted -O-aryl, an optionally substituted -O-heteroaryl and an optionally substituted -O-monocyclic heterocyclyl; R 14A, R 14B, R 15A and R 15B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl and an optionally substituted aryl; n is 0 or 1; p and q are independently 1 or 2; s and t are independently 3, 4 or 5; Z 1, Z 1A and Z 1B are independently O or S; and provided that when R 4 is and R 5A is O - or OH, then R 5B is O -, OH, or an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester, or a pharmaceutically acceptable salt of the foregoing. B 1 is selected from the group consisting of an optionally substituted and an optionally substituted R 1 is selected from the group consisting of an optionally substituted C 1-6 alkyl, an optionally substituted C 2-6 alkenyl, an optionally substituted C 2-6 alkynyl and an optionally substituted C 3-6 cycloalkyl; each -------- is absent and R p is absent; R 2 is halo, N 3, -OR 7A or -N(R 7B R 7C); R 3 is -OH or -OC(=O)R 8; or R 2 and R 3 are each an oxygen atom which are linked together by a carbonyl group; R 4 is hydrogen or R 5A is selected from the group consisting of O -, OH, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester, and R 5B is selected from the group consisting of O -, OH, an -O-optionally substituted aryl, an -O-optionally substituted heteroaryl, an -O-optionally substituted heterocyclyl, an optionally substituted N-linked amino acid, an optionally substituted N-linked amino acid ester, R 6B and R 6C are independently selected from the group consisting of hydrogen, an unsubstituted C 1-6 alkyl, an unsubstituted C 3-6 alkenyl, an unsubstituted C 3-6 alkynyl and an unsubstituted C 3-6 cycloalkyl; R 7A is hydrogen or -C(=O)R 12; R 7B and R 7C are independently hydrogen or an optionally substituted C 1-6 alkyl; R 8 and R 12 are independently an optionally substituted C 1-6 alkyl or an optionally substituted C 3-6 cycloalkyl; R 9, R 10 and R 11 are independently absent or hydrogen; R 8A, R 9A, R 11A, R 12A, R 8B, R 9B, R 11B and R 12B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl and an optionally substituted aryl; R 10A, R 10B, R 13A and R 13B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl, an optionally substituted aryl, an optionally substituted -O-C 1-24 alkyl, an optionally substituted -O-aryl, an optionally substituted -O-heteroaryl and an optionally substituted -O-monocyclic heterocyclyl; R 14A, R 14B, R 15A and R 15B are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 alkyl and an optionally substituted aryl; n is 0 or 1; p and q are independently 1 or 2; s and t are independently 3, 4 or 5; Z 1, Z 1A and Z 1B are independently O or S; and provided that when R 4 is and R 5A is O - or OH, then R 5B is O -, OH, or an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester, or a pharmaceutically acceptable salt of the foregoing.