A compound of Formula I: or pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof wherein: L 1 is straight or branched C 2 -C 4 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, D, OR 10, NH 2, NHR 10, and N(R 10)(R 10') provided that no more than one oxygen or nitrogen is attached to any carbon; or L 1 is selected from the group consisting of -CO-C 1 -C 2 alkylenyl-, -S 2 -, -S 2 NH-,-C NH-, -C NR 10 -, -C 1 -C 3 alkylenyl-C -C 1 -C 3 alkylenyl-, and a bond, wherein the C 1 -C 2 alkylenyl and C 1 -C 3 alkylenyl is optionally substituted with C 1 -C 4 alkyl; Each R 10 and R 10' is independently selected from the group consisting of H; O-C 1 -C 5 alkyl; C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, -OP 2, OP O 2 -2 M 2,-OC alkyl, -OC Oalkyl, aryl, and heteroaryl; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl; provided that no more than one oxygen is attached to any carbon of R 10 and R 10'; M is a monovalent metal cation; or R 10 and R 10', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is aryl or heteroaryl, both of which optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, -O-R 10, -OP 2, OP O 2 -2 M 2, - SH, -S-R 10, C 1 -C 5 alkyl, branched alkyl, -C 1 -C 6 haloalkyl, NH 2, NHR 10, -C 1 -C 6 hydroxyalkyl, N(R 10)(NR 10'), -NHS 2 R 10, -O-alkylaryl, -O-(CH 2) n -C -aryl, and NHCOR 10; M is a monovalent metal cation; or R 1 is cycloalkyl; X is selected from the group consisting of H, halogen, OH, O-C 1 -C 6 alkyl, O-branched alkyl, C 1 -C 5 straight alkyl and C 1 -C 5 branched alkyl; Y and Y' are independently H, F, or methyl; L 2 is -(CH 2) n - or -(CHR 11) n -, or a bond; Each R 11 is independently selected from the group consisting of H, -C 1 -C 5 alkylenyl-, -C -C 1 -C 5 alkylenyl-, and -alkylenyl-CO-alkylenyl-; R 2 is C 3 -C 8 cycloalkyl; C 3 -C 8 heterocyclyl, phenyl, naphthyl, heteroaryl, or bicyclic heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, C 1 -C 6 alkyl, OR 10, CN, NH 2, NHR 10, N(R 10)(R 10'), SH, SR 10, SOR 10, SO 2 R 10, SO 2 NHR 10, SO 2 N(R 10)(R 10'), CONH 2, CONR 10, and CON(R 10)(R 10'); and n is 1, 2, or 3. L 1 is straight or branched C 2 -C 4 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, D, OR 10, NH 2, NHR 10, and N(R 10)(R 10') provided that no more than one oxygen or nitrogen is attached to any carbon; or L 1 is selected from the group consisting of -CO-C 1 -C 2 alkylenyl-, -S 2 -, -S 2 NH-,-C NH-, -C NR 10 -, -C 1 -C 3 alkylenyl-C -C 1 -C 3 alkylenyl-, and a bond, wherein the C 1 -C 2 alkylenyl and C 1 -C 3 alkylenyl is optionally substituted with C 1 -C 4 alkyl; Each R 10 and R 10' is independently selected from the group consisting of H; O-C 1 -C 5 alkyl; C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, -OP 2, OP O 2 -2 M 2,-OC alkyl, -OC Oalkyl, aryl, and heteroaryl; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl; provided that no more than one oxygen is attached to any carbon of R 10 and R 10'; M is a monovalent metal cation; or R 10 and R 10', together with the nitrogen to which they are attached, may form a heterocycle; Each R 10 and R 10' is independently selected from the group consisting of H; O-C 1 -C 5 alkyl; C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, -OP 2, OP O 2 -2 M 2,-OC alkyl, -OC Oalkyl, aryl, and heteroaryl; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl; provided that no more than one oxygen is attached to any carbon of R 10 and R 10'; M is a monovalent metal cation; or R 10 and R 10', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is aryl or heteroaryl, both of which optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, -O-R 10, -OP 2, OP O 2 -2 M 2, - SH, -S-R 10, C 1 -C 5 alkyl, branched alkyl, -C 1 -C 6 haloalkyl, NH 2, NHR 10, -C 1 -C 6 hydroxyalkyl, N(R 10)(NR 10'), -NHS 2 R 10, -O-alkylaryl, -O-(CH 2) n -C -aryl, and NHCOR 10; M is a monovalent metal cation; or - SH, -S-R 10, C 1 -C 5 alkyl, branched alkyl, -C 1 -C 6 haloalkyl, NH 2, NHR 10, -C 1 -C 6 hydroxyalkyl, N(R 10)(NR 10'), -NHS 2 R 10, -O-alkylaryl, -O-(CH 2) n -C -aryl, and NHCOR 10; M is a monovalent metal cation; or R 1 is cycloalkyl; X is selected from the group consisting of H, halogen, OH, O-C 1 -C 6 alkyl, O-branched alkyl, C 1 -C 5 straight alkyl and C 1 -C 5 branched alkyl; Y and Y' are independently H, F, or methyl; L 2 is -(CH 2) n - or -(CHR 11) n -, or a bond; Each R 11 is independently selected from the group consisting of H, -C 1 -C 5 alkylenyl-, -C -C 1 -C 5 alkylenyl-, and -alkylenyl-CO-alkylenyl-; R 2 is C 3 -C 8 cycloalkyl; C 3 -C 8 heterocyclyl, phenyl, naphthyl, heteroaryl, or bicyclic heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, C 1 -C 6 alkyl, OR 10, CN, NH 2, NHR 10, N(R 10)(R 10'), SH, SR 10, SOR 10, SO 2 R 10, SO 2 NHR 10, SO 2 N(R 10)(R 10'), CONH 2, CONR 10, and CON(R 10)(R 10'); and n is 1, 2, or 3.