mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for producing human iPS cells from hematopoietic progenitor cells, the method comprising the steps of: a) culturing a cell population of human peripheral blood cells comprising hematopoietic progenitor cells under expansion conditions to promote the expansion of said hematopoietic progenitor cells; b) introducing exogenous episomal genetic elements or exogenous RNA genetic elements that express iPS reprogramming factors into said expanded hematopoietic progenitor cells; c) optionally culturing said cells under a condition comprising a reprogramming medium comprising a GSK-3 inhibitor, a MEK inhibitor, a TGF-β receptor inhibitor, a myosin II ATPase inhibitor, and/or a Rho-associated kinase (ROCK) signaling inhibitor; and d) culturing said expanded hematopoietic progenitor cells in a xeno-free culture, thereby producing human iPS cells from said hematopoietic progenitor cells. a) culturing a cell population of human peripheral blood cells comprising hematopoietic progenitor cells under expansion conditions to promote the expansion of said hematopoietic progenitor cells; b) introducing exogenous episomal genetic elements or exogenous RNA genetic elements that express iPS reprogramming factors into said expanded hematopoietic progenitor cells; c) optionally culturing said cells under a condition comprising a reprogramming medium comprising a GSK-3 inhibitor, a MEK inhibitor, a TGF-β receptor inhibitor, a myosin II ATPase inhibitor, and/or a Rho-associated kinase (ROCK) signaling inhibitor; and d) culturing said expanded hematopoietic progenitor cells in a xeno-free culture, thereby producing human iPS cells from said hematopoietic progenitor cells.
A tissue anchor comprising: a body oriented on a longitudinal axis, the body having a leading end, a leading end portion extending from the leading end, a trailing end portion connected to the leading end portion, with the trailing end portion terminating in a trailing end that is located opposite of the leading end; first and second protrusions formed on the leading end portion of the body, with each of the first and second protrusions extending outward in a radial direction perpendicular to the longitudinal axis, with a first anchor width measured between the first and second protrusions being greater than a second anchor width measured at the trailing end portion of the body; a tissue engaging fin integrated with the leading end portion of the body and oriented in a direction perpendicular to the radial direction of the first and second protrusions, the tissue engaging fin having a fin width and provided with an eyelet formed through the fin width; and characterized in an insertion tab removably attached to the tissue engaging fin. a body oriented on a longitudinal axis, the body having a leading end, a leading end portion extending from the leading end, a trailing end portion connected to the leading end portion, with the trailing end portion terminating in a trailing end that is located opposite of the leading end; first and second protrusions formed on the leading end portion of the body, with each of the first and second protrusions extending outward in a radial direction perpendicular to the longitudinal axis, with a first anchor width measured between the first and second protrusions being greater than a second anchor width measured at the trailing end portion of the body; a tissue engaging fin integrated with the leading end portion of the body and oriented in a direction perpendicular to the radial direction of the first and second protrusions, the tissue engaging fin having a fin width and provided with an eyelet formed through the fin width; and characterized in an insertion tab removably attached to the tissue engaging fin.
A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N and comprising - an opioid, - a free physiologically acceptable acid in an amount of 0.3 ± 0.18 wt.-%, based on the total weight of the pharmaceutical dosage form, and - a polyalkylene oxide having a weight average molecular weight M w of at least 500,000 g/mol, wherein the acid is a multicarboxylic acid. - an opioid, - a free physiologically acceptable acid in an amount of 0.3 ± 0.18 wt.-%, based on the total weight of the pharmaceutical dosage form, and - a polyalkylene oxide having a weight average molecular weight M w of at least 500,000 g/mol, wherein the acid is a multicarboxylic acid.
A class-D amplifier, comprising: a loop filter (102/302), a pulse-width modulation signal generator (104/304), a gate driver (106/306), a power driver (108/308), and a feedback circuit (Rfbp and Rfbn/Rfb), configured to establish a closed amplification loop, wherein the feedback circuit is configured to establish a feedback path; and a feedback breaker (110, RTO_SWp and RTO_SWn/ 310 and RTO_SW), configured to break the feedback path in response to determining that a no-signal information condition of the class-D amplifier has been met, wherein: an input signal of the class-D amplifier is coupled to the input of the loop filter; the output of the loop filter is coupled to the input of the pulse-width modulation signal generator; the feedback circuit is coupled between the output of the power driver and the input of the loop filter to establish the feedback path; the pulse-width modulation signal generator generates a first pulse-width modulation signal (Vpwmp) and a second pulse-width modulation signal (Vpwmn), and the feedback breaker determines that the no-signal information condition has been met based on the first pulse-width modulation signal being equal to the second pulse-width modulation signal. a loop filter (102/302), a pulse-width modulation signal generator (104/304), a gate driver (106/306), a power driver (108/308), and a feedback circuit (Rfbp and Rfbn/Rfb), configured to establish a closed amplification loop, wherein the feedback circuit is configured to establish a feedback path; and a feedback breaker (110, RTO_SWp and RTO_SWn/ 310 and RTO_SW), configured to break the feedback path in response to determining that a no-signal information condition of the class-D amplifier has been met, wherein: an input signal of the class-D amplifier is coupled to the input of the loop filter; the output of the loop filter is coupled to the input of the pulse-width modulation signal generator; the feedback circuit is coupled between the output of the power driver and the input of the loop filter to establish the feedback path; the pulse-width modulation signal generator generates a first pulse-width modulation signal (Vpwmp) and a second pulse-width modulation signal (Vpwmn), and the feedback breaker determines that the no-signal information condition has been met based on the first pulse-width modulation signal being equal to the second pulse-width modulation signal. an input signal of the class-D amplifier is coupled to the input of the loop filter; the output of the loop filter is coupled to the input of the pulse-width modulation signal generator; the feedback circuit is coupled between the output of the power driver and the input of the loop filter to establish the feedback path; the pulse-width modulation signal generator generates a first pulse-width modulation signal (Vpwmp) and a second pulse-width modulation signal (Vpwmn), and the feedback breaker determines that the no-signal information condition has been met based on the first pulse-width modulation signal being equal to the second pulse-width modulation signal.
A device for dewatering dredged material, comprising a tank, a first outlet for cleaned water and a second outlet for sludge, the tank further comprising a mixing chamber and a sedimentation chamber in which the first and the second outlet are arranged, where the mixing chamber and the sedimentation chamber are in fluid communication, wherein a turbulence means is provided for creating a turbulent flow in the mixing chamber for mixing incoming dredged material with the at least one flocculation chemical, said turbulence means being a surface facing the outlet opening, the surface having at least one protrusion protruding from the surface, said turbulence means being arranged at a predetermined distance from the outlet opening, characterised in that - the device is adapted for dewatering dredged material with a dry substance rate below 15%; - said tank is arranged with at least one inlet conduit for dredged material; - said inlet conduit for dredged masses leads to said mixing chamber; - said turbulence means being arranged centrally in the mixing chamber; - said inlet conduit has one end on the outside of the tank for connection with an external tube, and an outlet opening in the mixing chamber; - said inlet conduit including injection means for injection of at least one flocculation chemical to the inlet; - said turbulence means is surrounded by an open-ended, substantially cylindrical object, the cylindrical object further surrounding said outlet opening; and - an evacuation means (19, 21) is provided for removing larger objects like stones and gravel from the bottom of the mixing chamber, via a third outlet of the tank. - the device is adapted for dewatering dredged material with a dry substance rate below 15%; - said tank is arranged with at least one inlet conduit for dredged material; - said inlet conduit for dredged masses leads to said mixing chamber; - said turbulence means being arranged centrally in the mixing chamber; - said inlet conduit has one end on the outside of the tank for connection with an external tube, and an outlet opening in the mixing chamber; - said inlet conduit including injection means for injection of at least one flocculation chemical to the inlet; - said turbulence means is surrounded by an open-ended, substantially cylindrical object, the cylindrical object further surrounding said outlet opening; and - an evacuation means (19, 21) is provided for removing larger objects like stones and gravel from the bottom of the mixing chamber, via a third outlet of the tank.
A composition for a gel polymer electrolyte, comprising: a solvent; a lithium salt; and a first monomer represented by the following Formula 1: [Formula 1] R-CH (3-n) (̵N=C=O) n in Formula 1, R is a C 1-5 alkyl group or a C 1-20 aryl group including an acrylate group or a methacrylate group, and n is an integer of 1 to 3, wherein the composition further comprises a second monomer, wherein the second monomer is dipentaerythritol pentaacrylate or dipentaerythritol triacrylate. a solvent; a lithium salt; and a first monomer represented by the following Formula 1: [Formula 1] R-CH (3-n) (̵N=C=O) n in Formula 1, R is a C 1-5 alkyl group or a C 1-20 aryl group including an acrylate group or a methacrylate group, and n is an integer of 1 to 3, wherein the composition further comprises a second monomer, wherein the second monomer is dipentaerythritol pentaacrylate or dipentaerythritol triacrylate. in Formula 1, R is a C 1-5 alkyl group or a C 1-20 aryl group including an acrylate group or a methacrylate group, and n is an integer of 1 to 3, wherein the composition further comprises a second monomer, wherein the second monomer is dipentaerythritol pentaacrylate or dipentaerythritol triacrylate.
A process for producing water-absorbing polymer particles by polymerizing a monomer solution or suspension comprising a) at least one ethylenically unsaturated monomer which bears acid groups and may be at least partially neutralized, b) at least one crosslinker, c) at least one initiator, d) optionally one or more ethylenically unsaturated monomers copolymerizable with the monomers mentioned under a) and e) optionally one or more water-soluble polymers, comprising drying, grinding and classifying by means of at least one tumbler screening machine, wherein the tumbler screening machine used for classification is equipped with at least one ball knock cleaning system consisting of a base tray with elastic balls below a screen, the balls have a starting diameter x and the base tray has passage orifices for particles with a maximum particle diameter y, where y is less than x, and entrained elastic balls are removed outside the tumbler screening machine by means of a capture device, said capture device having passage orifices for particles with a maximum particle diameter z, where z is less than y. a) at least one ethylenically unsaturated monomer which bears acid groups and may be at least partially neutralized, b) at least one crosslinker, c) at least one initiator, d) optionally one or more ethylenically unsaturated monomers copolymerizable with the monomers mentioned under a) and e) optionally one or more water-soluble polymers,
A gripping device for at least one packet of long dried pasta comprising: - a support portion adapted to connect said gripping device to movement means to move at least one packet between a plurality of operating positions; - at least a first blocking portion and at least a second blocking portion reversibly movable closer and farther away along a movement direction parallel to a main extension axis of the packet between a gripping position, in which said at least a first blocking portion and at least a second blocking portion are arranged at a first distance so as to abut against respective opposite head portions of the packet to constrain the packet to the gripping device, and a release position, in which said at least a first blocking portion and at least a second blocking portion are arranged at a second distance greater than said first distance; wherein said first blocking portion and said second blocking portion are respectively defined by a plurality of first blocking elements and second blocking elements, each of said first blocking elements being arranged opposite a respective second blocking element with respect to said movement direction; characterised in that said first blocking elements and/or said second blocking elements are reversibly movable along a direction which is transverse, preferably perpendicular, to said movement direction between a mutual approaching configuration and a mutual distancing configuration. - a support portion adapted to connect said gripping device to movement means to move at least one packet between a plurality of operating positions; - at least a first blocking portion and at least a second blocking portion reversibly movable closer and farther away along a movement direction parallel to a main extension axis of the packet between a gripping position, in which said at least a first blocking portion and at least a second blocking portion are arranged at a first distance so as to abut against respective opposite head portions of the packet to constrain the packet to the gripping device, and a release position, in which said at least a first blocking portion and at least a second blocking portion are arranged at a second distance greater than said first distance; wherein said first blocking portion and said second blocking portion are respectively defined by a plurality of first blocking elements and second blocking elements, each of said first blocking elements being arranged opposite a respective second blocking element with respect to said movement direction; characterised in that said first blocking elements and/or said second blocking elements are reversibly movable along a direction which is transverse, preferably perpendicular, to said movement direction between a mutual approaching configuration and a mutual distancing configuration.
Method for controlling an electric machine during a synchronisation procedure of a first and a second shaft (11, 111; 12, 151, 152), whereby said first shaft (11, 111) is in drive connection with an output shaft (10, 110) of said electric machine and said first and said second shaft (11, 111; 12, 151, 152) is connectable over a synchronisation mechanism (13, 113a, 113b), said method comprises the steps of; - controlling output shaft (10, 110) to a speed (na) essentially corresponding to a target speed (nt) of said second shaft (12, 151, 152) by using speed control; - continuously controlling an electrical torque of said electrical machine, such that an output torque (Tout) of said electric machine becomes essentially equal to zero during the synchronisation procedure of the synchronisation mechanism (13, 113a, 113b); and - controlling said synchronisation mechanism (13, 113a, 113b, 13, 113a, 113b) to synchronise the speed of first and second shaft (11, 111; 12, 151, 152). - controlling output shaft (10, 110) to a speed (na) essentially corresponding to a target speed (nt) of said second shaft (12, 151, 152) by using speed control; - continuously controlling an electrical torque of said electrical machine, such that an output torque (Tout) of said electric machine becomes essentially equal to zero during the synchronisation procedure of the synchronisation mechanism (13, 113a, 113b); and - controlling said synchronisation mechanism (13, 113a, 113b, 13, 113a, 113b) to synchronise the speed of first and second shaft (11, 111; 12, 151, 152).
Piezo actuator having a multi-layer structure of piezo elements with piezo layers between internal electrodes (3, 4) to which an electric voltage is alternately applied with a different polarity in the direction of the layered structure of the piezo actuator, wherein at least one planar separating layer, which does not act as an internal electrode, with coatings arranged at least on the contact surface of the internal electrodes (3, 4), is arranged in predefined areas (7, 8) at predefined locations on the layered structure between the piezo elements, wherein the coatings are composed of metallic material which can be destroyed by sintering of the piezo actuator, wherein the internal electrodes (3, 4) which adjoin the respective separating layer each have the same polarity of the applied electrical voltage.
A device for measuring and/or modifying surface features of an object, the device comprising - a sample carrier having a surface for mounting the object; - a reference grid plate having a surface arranged in parallel with the surface of the sample carrier, at a distance from the surface of the sample carrier; - independently movable heads that are independently movable along the reference grid plate, each head comprising a microscopic probe, the heads being located between the sample carrier and the reference grid plate; and - a sensor or sensors for sensing relative positions of the heads with respect to markings on the reference grid plate; the device comprising means for exerting a force between at least one of the heads and the reference grid plate and means for switching a value of said force to seat and/or clamp the at least one of the heads on the reference grid plate. - a sample carrier having a surface for mounting the object; - a reference grid plate having a surface arranged in parallel with the surface of the sample carrier, at a distance from the surface of the sample carrier; - independently movable heads that are independently movable along the reference grid plate, each head comprising a microscopic probe, the heads being located between the sample carrier and the reference grid plate; and - a sensor or sensors for sensing relative positions of the heads with respect to markings on the reference grid plate; the device comprising means for exerting a force between at least one of the heads and the reference grid plate and means for switching a value of said force to seat and/or clamp the at least one of the heads on the reference grid plate.
Use of a marker for protecting valuable liquid and solid state materials against unauthorized substitution with second-hand or forged objects, comprising an organic or nonorganic liquid solvent as a dispersion medium, and a surface active substance on a nanomarker, characterised in that the nanomarker is a homogeneous mixture of two or more different nanoluminophors, wherein nanocrystallites of sizes between a few and a few tens of nanometers are used as the nanoluminophors and they are chosen from - metals exhibiting plasmonic bands chosen from Au, Ag, Pt, Rh, Re, Pd, Cu, - nanocrystalline metal oxides -A 2 O 3, granates-A 3 B 5 O 12, perovskites-ABO 3, spinels-AB 2 O 4 or - stoichiometric compounds chosen from fluorides and oxychlorides, doped with lanthanides or transitional metals, with large concentrations of optically active ions. - metals exhibiting plasmonic bands chosen from Au, Ag, Pt, Rh, Re, Pd, Cu, - nanocrystalline metal oxides -A 2 O 3, granates-A 3 B 5 O 12, perovskites-ABO 3, spinels-AB 2 O 4 or - stoichiometric compounds chosen from fluorides and oxychlorides,
A bone screw comprising: - a head portion comprising one or more longitudinal slits; - a shaft portion connected to the head portion, the shaft portion comprising an outer surface having a plurality of threads and a tapered distal end, the shaft portion further comprising a fenestration extending along a majority of the length of the threaded shaft portion and having a first section and a second section extending along the outer surface, wherein the first section extends along a first direction and the second section extends along a second direction angled relative to the first direction, wherein the first section begins at a proximal end of bone screw near the head portion and transitions into the second section via an angled corner, wherein the first section comprises a straight portion that extends along a longitudinal length of the shaft portion which transitions via the angled corner into the second section, wherein the one or more longitudinal slits are configured to allow for compressibility of the head portion; and - an inner opening extending from the head portion to the shaft portion, wherein the inner opening is in fluid contact with fenestration to distribute material introduced in the inner opening through fenestration. - a head portion comprising one or more longitudinal slits; - a shaft portion connected to the head portion, the shaft portion comprising an outer surface having a plurality of threads and a tapered distal end, the shaft portion further comprising a fenestration extending along a majority of the length of the threaded shaft portion and having a first section and a second section extending along the outer surface, wherein the first section extends along a first direction and the second section extends along a second direction angled relative to the first direction, wherein the first section begins at a proximal end of bone screw near the head portion and transitions into the second section via an angled corner, wherein the first section comprises a straight portion that extends along a longitudinal length of the shaft portion which transitions via the angled corner into the second section, wherein the one or more longitudinal slits are configured to allow for compressibility of the head portion; and - an inner opening extending from the head portion to the shaft portion, wherein the inner opening is in fluid contact with fenestration to distribute material introduced in the inner opening through fenestration.