An ultrasound imaging system for shear wave imaging comprising: an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward a target tissue, the target tissue comprising anisotropic tissue having an angular orientation with respect to a nominal axial direction of the ultrasound transducer; a beamformer configured to: control the ultrasound transducer to transmit a push pulse along a steering angle for generating a shear wave in the target tissue, wherein the steering angle is based on the angular orientation of the target tissue; transmit, from the ultrasound transducer, tracking pulses along laterally separated tracking lines parallel to the push pulse; and receive, from the ultrasound transducer, echo signals from points along the laterally separated tracking lines; and a processor in communication with the beamformer and configured to: store tracking line echo data generated from the received echo signals; in response to the tracking line echo data, detect motion within the target tissue caused by propagation of the shear wave therethrough; and measure the velocity of the shear wave, characterized in that the ultrasound imaging system further comprises a user interface configured to display a live ultrasound image of the target tissue and an ROI tracking box, the ROI tracking box configured to change shape in response to adjustment of the steering angle of the push pulse. an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward a target tissue, the target tissue comprising anisotropic tissue having an angular orientation with respect to a nominal axial direction of the ultrasound transducer; a beamformer configured to: control the ultrasound transducer to transmit a push pulse along a steering angle for generating a shear wave in the target tissue, wherein the steering angle is based on the angular orientation of the target tissue; transmit, from the ultrasound transducer, tracking pulses along laterally separated tracking lines parallel to the push pulse; and receive, from the ultrasound transducer, echo signals from points along the laterally separated tracking lines; and control the ultrasound transducer to transmit a push pulse along a steering angle for generating a shear wave in the target tissue, wherein the steering angle is based on the angular orientation of the target tissue; transmit, from the ultrasound transducer, tracking pulses along laterally separated tracking lines parallel to the push pulse; and receive, from the ultrasound transducer, echo signals from points along the laterally separated tracking lines; and a processor in communication with the beamformer and configured to: store tracking line echo data generated from the received echo signals; in response to the tracking line echo data, detect motion within the target tissue caused by propagation of the shear wave therethrough; and measure the velocity of the shear wave, store tracking line echo data generated from the received echo signals; in response to the tracking line echo data, detect motion within the target tissue caused by propagation of the shear wave therethrough; and measure the velocity of the shear wave, characterized in that the ultrasound imaging system further comprises a user interface configured to display a live ultrasound image of the target tissue and an ROI tracking box, the ROI tracking box configured to change shape in response to adjustment of the steering angle of the push pulse.