mhurhangee/ep-ind-claims huggingface dataset:
A method for obtaining monoclonal antibody molecules specific for oxidatively inactivated human parathyroid hormone (hPTH) peptide and circulating fragments thereof, comprising a) obtaining antibodies against human parathyroid hormone peptide by immunizing a non-human animal with an immunogen comprising as hapten the amino acid sequence 1 to 38 of parathyroid hormone oxidized at methionine 8, 18 or both, or a fragment comprising the amino acid sequence 1 to 38 of parathyroid hormone oxidized at methionine 8, 18 or both, and recovering said antibodies from said non-human animal; b) selecting or purifying said antibodies from antibody molecules that bind to bioactive human parathyroid hormone peptide under physiological conditions to obtain antibodies that specifically recognize oxidatively inactivated parathyroid hormone or fragments thereof; c) selecting or purifying said antibodies against oxidized parathyroid hormone from antibodies binding to an oxidatively inactivated hPTH peptide independent from the methionine R-sulfoxide, methionine L-sulfoxide or methionine sulfone at positions 8, 18 or both, to obtain or isolate antibody molecules which specifically bind to a conformational epitope (tertiary protein structure) of oxidatively inactivated human parathyroid hormone peptides and circulating fragments thereof, so that the obtained antibody molecules bind to an oxidatively inactivated hPTH peptide independent from the methionine R-sulfoxide, methionine L-sulfoxide or methionine sulfone at positions 8, 18 or both. a) obtaining antibodies against human parathyroid hormone peptide by immunizing a non-human animal with an immunogen comprising as hapten the amino acid sequence 1 to 38 of parathyroid hormone oxidized at methionine 8, 18 or both, or a fragment comprising the amino acid sequence 1 to 38 of parathyroid hormone oxidized at methionine 8, 18 or both, and recovering said antibodies from said non-human animal; b) selecting or purifying said antibodies from antibody molecules that bind to bioactive human parathyroid hormone peptide under physiological conditions to obtain antibodies that specifically recognize oxidatively inactivated parathyroid hormone or fragments thereof; c) selecting or purifying said antibodies against oxidized parathyroid hormone from antibodies binding to an oxidatively inactivated hPTH peptide independent from the methionine R-sulfoxide, methionine L-sulfoxide or methionine sulfone at positions 8, 18 or both, to obtain or isolate antibody molecules which specifically bind to a conformational epitope (tertiary protein structure) of oxidatively inactivated human parathyroid hormone peptides and circulating fragments thereof, so that the obtained antibody molecules bind to an oxidatively inactivated hPTH peptide independent from the methionine R-sulfoxide, methionine L-sulfoxide or methionine sulfone at positions 8, 18 or both.
A curcumin-boron complex represented by the following formula: wherein X 1 and X 2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X 3 represents a bromine atom, an iodine atom, or a selenium atom; R 1 and R 2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 3 and R 4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 1 and R 3 or R 2 and R 4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R 5 and R 6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 7 and R 8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 5 and R 7 or R 6 and R 8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof. X 3 represents a bromine atom, an iodine atom, or a selenium atom; R 1 and R 2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 3 and R 4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 1 and R 3 or R 2 and R 4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R 5 and R 6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 7 and R 8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 5 and R 7 or R 6 and R 8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3,
A method of providing an adaptive reference orientation usable for generating a relative head orientation of a user, the method implementable by a processing unit, the method comprising: repeatedly performing: a) receiving head data from a head sensor, said head data describing a head orientation associated with a user; b) receiving second data from a second sensor operating independently of the head sensor, said second data indicative of at least one of: a location, a motion, an orientation, a velocity and an acceleration of the user; c) generating a new adaptive reference orientation by moving a current adaptive reference orientation towards the described head orientation by an amount which is varied in accordance with the currently received second data; d) computing head orientation relative to the new adaptive reference orientation: and e) using the new adaptive reference orientation as the current adaptive reference orientation for a next repeat of operations a) - d). a) receiving head data from a head sensor, said head data describing a head orientation associated with a user; b) receiving second data from a second sensor operating independently of the head sensor, said second data indicative of at least one of: a location, a motion, an orientation, a velocity and an acceleration of the user; c) generating a new adaptive reference orientation by moving a current adaptive reference orientation towards the described head orientation by an amount which is varied in accordance with the currently received second data; d) computing head orientation relative to the new adaptive reference orientation: and e) using the new adaptive reference orientation as the current adaptive reference orientation for a next repeat of operations a) - d).
An acoustic dampening device of the room ventilation system, comprising a housing, in which a sound-absorbing material is arranged and which has a coupling side and a connection side lying opposite of the coupling side, wherein the coupling side has a plurality of coupling connections (19, 20, 21, 22) that can be fluidically connected to device connections of a ventilation device and the connection side has a plurality of connections (23, 24, 25, 26), wherein the number of coupling connections (19, 20, 21, 22) is identical to the number of connections (23, 24, 25, 26), wherein each connection (23, 24, 25, 26) of the connection side is fluidically connected to at least one coupling connection (19, 20, 21, 22) of the coupling side with the aid of an acoustic dampening channel (29, 30, 31, 32), and wherein a respective acoustic dampening channel (29, 30, 31, 32) is covered with the sound-absorbing material and/or the sound-absorbing material fills out the housing of the acoustic dampening device, characterized in that the connections (23, 24, 25, 26) on the connection side are arranged in accordance with a connection matrix (27', 27", 27''') and the coupling connections (19, 20, 21, 22) on the coupling side are arranged in accordance with a coupling matrix, wherein each connection (23, 24, 25, 26) is associated with a coupling connection (19, 20, 21, 22), which is arranged at the shortest distance from said connection, and wherein at least one of the connections (23, 24, 25, 26) is connected to one of the coupling connections (19, 20, 21, 22), which is arranged adjacent to the coupling connection (19, 20, 21, 22) associated with the at least one connection (23, 24, 25, 26), such that a connection occupancy of the connections (23, 24, 25, 26) on the connection side for different air types, which comprise outgoing air, exhaust air, external air and supply air, differs from the connection occupancy of the coupling connections (19, 20, 21, 22) on the coupling side for different air types.
A water circulation system for a pool, comprising: a water outlet assembly mounted to an inner wall of the pool and in fluid communication with an external pump through a water outlet pipe, said external pump drawing water out of the pool through the water outlet assembly; an air inlet assembly (60, 91) mounted to the pool at a preset distance from the water outlet assembly; an air outlet assembly (50, 90) attached to the water outlet assembly and in fluid communication with the water outlet assembly; and an air inlet passage (63, 91) connecting the air inlet assembly (60, 91) to the air outlet assembly (50, 90), wherein fluid can enter the air inlet assembly (60, 91) and be introduced to the water outlet assembly through the air outlet assembly (50, 90) when the water outlet assembly is blocked. a water outlet assembly mounted to an inner wall of the pool and in fluid communication with an external pump through a water outlet pipe, said external pump drawing water out of the pool through the water outlet assembly; an air inlet assembly (60, 91) mounted to the pool at a preset distance from the water outlet assembly; an air outlet assembly (50, 90) attached to the water outlet assembly and in fluid communication with the water outlet assembly; and an air inlet passage (63, 91) connecting the air inlet assembly (60, 91) to the air outlet assembly (50, 90), wherein fluid can enter the air inlet assembly (60, 91) and be introduced to the water outlet assembly through the air outlet assembly (50, 90) when the water outlet assembly is blocked.
An optical lens comprising a polyester resin comprising a unit of the following formula: wherein R 1 is a hydrogen atom, CH 3, or C 2 H 5, R 2 and R 3 are each independently a hydrogen atom or CH 3, and n is 1.
Sanitary wall installation connection box unit, comprising - a box housing body having a rear-side base portion and a sleeve portion projecting forward from the base portion, which sleeve portion peripherally surrounds a sanitary component mounting space, which space is accessible via an open front end face of the sleeve portion, and - a connector body disposed on the base portion of the box housing body, which connector body comprises a sanitary component connection contour facing the sanitary component mounting space, a fluid line connection interface structure accessible on an outer side of the box housing body, a fluid conduit structure for fluid connection of the fluid line connection interface structure to the sanitary component connection contour, and at least one electric line feed-through opening leading from an outer side of the connector body through the connector body to the sanitary component mounting space, characterized in that - the base portion of the box housing body is made of a sealing resilient material at least in an electric line connection region adjacent to the electric line feed-through opening of the connector body, and - the electric line feed-through opening of the connector body is covered on an outer side by a closure membrane made of the sealing resilient material of the electric line feed-through region of the base portion. - a box housing body having a rear-side base portion and a sleeve portion projecting forward from the base portion, which sleeve portion peripherally surrounds a sanitary component mounting space, which space is accessible via an open front end face of the sleeve portion, and - a connector body disposed on the base portion of the box housing body, which connector body comprises a sanitary component connection contour facing the sanitary component mounting space, a fluid line connection interface structure accessible on an outer side of the box housing body, a fluid conduit structure for fluid connection of the fluid line connection interface structure to the sanitary component connection contour, and at least one electric line feed-through opening leading from an outer side of the connector body through the connector body to the sanitary component mounting space, - the base portion of the box housing body is made of a sealing resilient material at least in an electric line connection region adjacent to the electric line feed-through opening of the connector body, and - the electric line feed-through opening of the connector body is covered on an outer side by a closure membrane made of the sealing resilient material of the electric line feed-through region of the base portion.
A system of an instrument for inserting a bone anchoring element and a polyaxial bone anchor comprising the bone anchoring element, the instrument including: a shaft having a front portion including an end portion (23, 23') for engaging the bone anchoring element and for transferring torque to the bone anchoring element (1, 1') and a longitudinal axis defining an axis of rotation; a cutting member (4, 4'), which is configured to be detachably mounted or non-detachably fixed to the front portion of the shaft or which is provided as a single piece with the shaft, with cutting portions that are configured to cut bone material; and the bone anchoring element (1, 1') that has a shank for anchoring in the bone and a head, characterized in that the head comprises at its free end a recess (14, 14') in which the end portion (23, 23') of the shaft of the instrument is engageable, and wherein the cutting member (4, 4') has an outer diameter defined by the cutting portions that is substantially the same or larger than an outer diameter (dd) of a receiving part of the polyaxial bone anchor in a region at a bottom end of the receiving part. a shaft having a front portion including an end portion (23, 23') for engaging the bone anchoring element and for transferring torque to the bone anchoring element (1, 1') and a longitudinal axis defining an axis of rotation; a cutting member (4, 4'), which is configured to be detachably mounted or non-detachably fixed to the front portion of the shaft or which is provided as a single piece with the shaft, with cutting portions that are configured to cut bone material; and the bone anchoring element (1, 1') that has a shank for anchoring in the bone and a head, characterized in that the head comprises at its free end a recess (14, 14') in which the end portion (23, 23') of the shaft of the instrument is engageable, and wherein the cutting member (4, 4') has an outer diameter defined by the cutting portions that is substantially the same or larger than an outer diameter (dd) of a receiving part of the polyaxial bone anchor in a region at a bottom end of the receiving part.
A non-contact charging module comprising: a planar coil formed of a wound conductive wire having a winding part and a leg part which partly overlaps the winding part; and a magnetic sheet on which the planar coil is mounted; the magnetic sheet being separated into a plurality of magnetic portions by a plurality of first slits wherein the magnetic sheet is held together by tape adhered to opposite surfaces of the magnetic sheet, the magnetic sheet being flexible due to the provision of the plurality of first slits and the tape, characterized by a recessed portion or a second slit which is provided in a position of the magnetic sheet on which the leg part of the planar coil is mounted, the recessed portion or the second slit housing the leg part of the planar coil; and wherein a relationship between width W of the recessed portion or the second slit and pitch P of the plurality of first slits is W ≥P; a virtual extension of at least one first slit is placed within the width of the recessed portion or the second slit and runs along the recessed portion or the second slit. a planar coil formed of a wound conductive wire having a winding part and a leg part which partly overlaps the winding part; and a magnetic sheet on which the planar coil is mounted; the magnetic sheet being separated into a plurality of magnetic portions by a plurality of first slits wherein the magnetic sheet is held together by tape adhered to opposite surfaces of the magnetic sheet, the magnetic sheet being flexible due to the provision of the plurality of first slits and the tape, characterized by a recessed portion or a second slit which is provided in a position of the magnetic sheet on which the leg part of the planar coil is mounted, the recessed portion or the second slit housing the leg part of the planar coil; and wherein a relationship between width W of the recessed portion or the second slit and pitch P of the plurality of first slits is W ≥P; a virtual extension of at least one first slit is placed within the width of the recessed portion or the second slit and runs along the recessed portion or the second slit.
: A lens-based display apparatus useful as an optical security element, comprising: a lens array with a first side comprising a plurality of lenses and a second side opposite the first side; and a printed interlaced image proximate to the second side of the lens array comprising a first set of pixels of the printed interlaced image formed with a first layer of ink of a first color, wherein the first set of pixels are located underneath a first set of the lenses of the lens array, characterised in that the printed interlaced image further comprises a second set of pixels of the printed interlaced image formed with a second layer of ink of a second color, wherein the second set of pixels are located underneath a second set of the lenses of the lens array that differs from the first set of the lenses, and wherein the first set of pixels are located at locations under each of the lenses in the first set of the lenses that differ from locations of the second set of pixels under each of the lenses in the second set of the lenses. a lens array with a first side comprising a plurality of lenses and a second side opposite the first side; and a printed interlaced image proximate to the second side of the lens array comprising a first set of pixels of the printed interlaced image formed with a first layer of ink of a first color, wherein the first set of pixels are located underneath a first set of the lenses of the lens array, characterised in that the printed interlaced image further comprises a second set of pixels of the printed interlaced image formed with a second layer of ink of a second color, wherein the second set of pixels are located underneath a second set of the lenses of the lens array that differs from the first set of the lenses, and wherein the first set of pixels are located at locations under each of the lenses in the first set of the lenses that differ from locations of the second set of pixels under each of the lenses in the second set of the lenses.
An apparatus, comprising: a video encoder for encoding picture data for at least a portion of a picture, wherein the video encoder includes an adaptive filter for performing filtering of prediction data in an intra prediction for a chroma component of the portion of the picture, wherein at least one of filter parameters for the filtering is adapted, wherein the prediction data is filtered to obtain filtered prediction data, and a prediction value of the prediction data in the intra prediction for the chroma component of the portion of the picture is a function of the prediction data and the filtered prediction data; and wherein an edge detection is used to determine whether the adaptive filtering is used or by-passed and the edge detection is used to determine at least one of a filter length and a filter strength applied to each pixel of the chroma component, wherein said edge detection detects an edge that is determined depending on a difference between two adjacent chroma pixels of the prediction data. a video encoder for encoding picture data for at least a portion of a picture, wherein the video encoder includes an adaptive filter for performing filtering of prediction data in an intra prediction for a chroma component of the portion of the picture, wherein at least one of filter parameters for the filtering is adapted, wherein the prediction data is filtered to obtain filtered prediction data, and a prediction value of the prediction data in the intra prediction for the chroma component of the portion of the picture is a function of the prediction data and the filtered prediction data; and wherein an edge detection is used to determine whether the adaptive filtering is used or by-passed and the edge detection is used to determine at least one of a filter length and a filter strength applied to each pixel of the chroma component, wherein said edge detection detects an edge that is determined depending on a difference between two adjacent chroma pixels of the prediction data.
Motor vehicle tank, comprising a tank container formed by a tank wall, and a component which is fastened to the tank wall in the interior of the tank container by means of a holding element, wherein the holding element has at least one attachment point for fastening the holding element to the tank wall, wherein the holding element has at least one fastening element for fastening the component to the holding element, wherein the holding element has spring elements between the attachment point and the fastening element, thus ensuring that the component is fastened to the tank wall in a spring-elastically decoupled manner by means of the holding element characterized in that the attachment point is fastened directly to the tank wall wherein the holding element has at least three attachment points, and circular shaped attachment spring elements, which form spring elements, in each case connect two adjacent attachment points to one another wherein the holding element comprises a surface consisting of a soft material as the spring element, wherein the surface is connected to attachment spring elements of the holding element at least in sections of the outer circumference of said surface.
An isolated genetically engineered host mammalian cell, which comprises exogenous genes encoding a fucosidase, and an Endo S enzyme, wherein the engineered host mammalian cell produces glycoproteins having modified glycosylation as compared with the glycoproteins produced by a wild-type counterpart.
A composition comprising: (a) from 60 to 85 wt% vegetable oil; (b) an aliphatic quaternary ammonium salt having from five to twenty carbon atoms and from two to six hydroxyl groups; and (c) a surfactant package.