mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical product comprising (i) a first composition comprising, as an active agent, vemurafenib, or a pharmaceutically-acceptable salt thereof; and (ii) a second composition comprising, as an active agent, an MDM2 inhibitor, or a pharmaceutically acceptable salt thereof; as a combined preparation for the concomitant or sequential use in the treatment of cancer; the amount of said active agents being such that the combination thereof is therapeutically-effective in the treatment of a cancer comprising V600 mutation positive b-Raf.
Method of producing a toothbrush with a brush body having a neck part and a head part adjoining the same, and with a carrier element produced separately on which conventional bristles are fitted, which is connected to the brush body via a mount which is adapted to the carrier element and is located on the head part, characterized in that the following steps are comprised: a) providing the carrier element with conventional bristles; b) connecting in a non-releasable manner the carrier element to the mount of the brush body; c) subsequently applying a pressing force to the carrier element and/or to the brush body, in order to check the adherence between the carrier element and the mount of the brush body. a) providing the carrier element with conventional bristles; b) connecting in a non-releasable manner the carrier element to the mount of the brush body; c) subsequently applying a pressing force to the carrier element and/or to the brush body, in order to check the adherence between the carrier element and the mount of the brush body.
A method, performed by an electronic device mounted on a vehicle, of controlling an internal system of the vehicle, the method comprising: identifying a wireless data communication identifier, ID, of a mobile device; obtaining environment configuration information of the vehicle from the identified wireless data communication ID by assigning each character string of the identified wireless data communication ID to a configuration parameter value according to a preset rule; and controlling a configuration of the internal system of the vehicle by using the obtained environment configuration information. identifying a wireless data communication identifier, ID, of a mobile device; obtaining environment configuration information of the vehicle from the identified wireless data communication ID by assigning each character string of the identified wireless data communication ID to a configuration parameter value according to a preset rule; and controlling a configuration of the internal system of the vehicle by using the obtained environment configuration information.
A method to identify relative cancer risk in a human subject, comprising identifying whether a test tissue sample of the test human comprises at least one transcribed ultraconserved regions (T-UCR) expression profile that has a statistically significant correlation with colorectal cancer; wherein the T-UCR expression profile comprises at least uc.73; wherein a statistically significant correlation indicates relative risk for CRC; and wherein the T-UCRs in the T-UCR expression profile are differentially expressed between normal and malignant cells.
A tube clamping device comprising: (a) a fixed base installed on a tube treatment line; (b) a lifting/lowering base provided onto the fixed base to be able to lift and lower; (c) a first drive mechanism mounted to the fixed base so as to drive the lifting/lowering base for lifting and lowering; (d) paired opposite clamp claws mounted in positions to be able to turn so as to clamp the tube; characterized in that the tube clamping device further comprising: (e) a lifting/lowering claw drive body provided in the lifting/lowering base so as to lift and lower independently of the lifting/lowering base and having opposite side portions connected to the opposite clamp claws by links so as to turn the clamp claws on opposite sides of the lifting/lowering base in closing directions by lowering with respect to the lifting/lowering base; and (f) a second drive mechanism mounted to the fixed base so as to drive the claw drive body for lifting and lowering; and further characterized in that the lifting/lowering base including a tube support body (62a, 62b) for supporting and centering a tube on itself and in that the paired opposite clamp claws are mounted in positions between which the tube support body (62a, 62b) of the lifting/lowering base is sandwiched, to be able to turn so as to clamp the tube supported on the tube support body (62a, 62b). (a) a fixed base installed on a tube treatment line; (b) a lifting/lowering base provided onto the fixed base to be able to lift and lower; (c) a first drive mechanism mounted to the fixed base so as to drive the lifting/lowering base for lifting and lowering; (d) paired opposite clamp claws mounted in positions to be able to turn so as to clamp the tube; (e) a lifting/lowering claw drive body provided in the lifting/lowering base so as to lift and lower independently of the lifting/lowering base and having opposite side portions connected to the opposite clamp claws by links so as to turn the clamp claws on opposite sides of the lifting/lowering base in closing directions by lowering with respect to the lifting/lowering base; and (f) a second drive mechanism mounted to the fixed base so as to drive the claw drive body for lifting and lowering; and
A system for de-erection and re-erection of a blade of a wind turbine, said system comprising: • at least one first pulley; • at least one second pulley mounted on at least one blade adjacent to said blade; • at least one third pulley; • a receptacle disposed over a substantial length of said blade; • a lifting line; • at least one load bearing mechanism configured for pulling and releasing of said lifting line to enable vertical motion of said receptacle disposed over said blade; • a load supporting mechanism connected to an operative bottom portion of said blade and configured to support said blade during de-erection and re-erection thereof; and • at least one holding mechanism adapted to hold said receptacle, characterized in that said at least one first pulley is mounted at the bottom of said wind turbine; • a jig is mounted at the bottom of said wind turbine, said jig is adapted to mount said at least one first pulley; • said at least one second pulley is positioned in line with said at least one first pulley; • said at least one third pulley is forming a Gun Tackle arrangement with said at least one second pulley; • said lifting line is passing over said at least one first pulley, said at least one second pulley, said at least one third pulley and is attached back to said at least one second pulley; and • said at least one holding mechanism is attached to said at least one third pulley. • at least one first pulley; • at least one second pulley mounted on at least one blade adjacent to said blade; • at least one third pulley; • a receptacle disposed over a substantial length of said blade; • a lifting line; • at least one load bearing mechanism configured for pulling and releasing of said lifting line to enable vertical motion of said receptacle disposed over said blade; • a load supporting mechanism connected to an operative bottom portion of said blade and configured to support said blade during de-erection and re-erection thereof; and • at least one holding mechanism adapted to hold said receptacle, • a jig is mounted at the bottom of said wind turbine, said jig is adapted to mount said at least one first pulley; • said at least one second pulley is positioned in line with said at least one first pulley; • said at least one third pulley is forming a Gun Tackle arrangement with said at least one second pulley; • said lifting line is passing over said at least one first pulley, said at least one second pulley, said at least one third pulley and is attached back to said at least one second pulley; and • said at least one holding mechanism is attached to said at least one third pulley.
A powder for solid freeform fabrication comprising: a first resin particle; and a second resin particle, wherein a mass ratio of the first resin particle to the second resin particle is from 4:6 to 9.8:0.2 in the powder, wherein MFR2 is greater than MFR1 and a ratio of MFR2 to MFR1 is from 2 to 5, where MFR1 represents a melt mass-flow rate of the first resin particle and MFR2 represents a melt mass-flow rate of the second resin particle, wherein MFR is measured according to JIS 7210 format, wherein the first resin particle and the second resin particle are of the same kind of resin, wherein the volume average particle diameter of the first resin particle and the volume average particle diameter of the second resin particle are from 5 to 200 μm. a first resin particle; and a second resin particle, wherein a mass ratio of the first resin particle to the second resin particle is from 4:6 to 9.8:0.2 in the powder, wherein MFR2 is greater than MFR1 and a ratio of MFR2 to MFR1 is from 2 to 5, where MFR1 represents a melt mass-flow rate of the first resin particle and MFR2 represents a melt mass-flow rate of the second resin particle, wherein MFR is measured according to JIS 7210 format, wherein the first resin particle and the second resin particle are of the same kind of resin, wherein the volume average particle diameter of the first resin particle and the volume average particle diameter of the second resin particle are from 5 to 200 μm.
A method of arranging a P2P network comprising a streaming source and network peers arranged at distribution levels in the P2P network, in which P2P network the streaming source is arranged to divide data content to be streamed into a plurality of content sub-streams together forming the data content and to distribute the plurality of content sub-streams to the network peers, the method comprising: instructing (S203a) a network peer requesting to download data content to download a single content sub-stream from a respective one of selected network peers being arranged at a distribution level closer to the streaming source than the requesting network peer until a number of content sub-streams have been downloaded by the requesting network peer from which the requested data content can be formed. instructing (S203a) a network peer requesting to download data content to download a single content sub-stream from a respective one of selected network peers being arranged at a distribution level closer to the streaming source than the requesting network peer until a number of content sub-streams have been downloaded by the requesting network peer from which the requested data content can be formed.
Use of an effective quantity of at least one peptide corresponding to the general formula: Cys-Gly as an antioxidant and/or anti-radical agent, alone or in association with at least one further active agent, in or for the preparation of a cosmetic and/or dermatological composition, characterised in that the peptide is dimerised by means of a disulphide bond.
A light-responsive ion channel protein comprising an amino acid sequence having at least 75% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1 or SEQ ID NO:2, wherein the ion channel exhibits an extended conducting state after exposure to a light pulse; and wherein the protein comprises a Cys→Thr, a Cys→Ala, or a Cys→Ser substitution at a position corresponding to amino acid 128 of SEQ ID NO:1 / amino acid 123 of SEQ ID NO:2, and an Asp→Ala, or an Asp→Asn substitution at a position corresponding to amino acid 156 of SEQ ID NO:1 / amino acid 151 of SEQ ID NO:2.
Elementary acoustic metamaterial cell, comprising: - a body made of solid material, and - at least one resonator in the form of a groove having a width I and depth p, characterized in that said groove is open only on a surface of said body in a cylindrical shape, the groove(s) being folded in a cross section which is orthogonal to said surface so as to have only one opening at said surface and a plurality of plies within the cell. - a body made of solid material, and - at least one resonator in the form of a groove having a width I and depth p,
Process for the preparation of isocyanates by reacting primary amines with a stoichiometric excess of phosgene in the gas phase, wherein a) the amine is reacted with phosgene in a reactor above the boiling point of the amine, where a liquid stream containing the isocyanate and a gas stream containing HCl and phosgene are obtained, and b) the gas stream containing HCl and phosgene obtained in step a) is first separated, in a sequence consisting of an isothermal and an adiabatic absorption step, into a gas stream containing HCl and a liquid stream containing phosgene, and c) the liquid stream containing phosgene obtained in step b) is then separated into a gas stream containing phosgene and into a liquid stream, where the temperature of the liquid stream containing phosgene obtained from step b) is raised before entering step c), where the increase in temperature between exiting step b) and entering step c) is between 5-175°C, and d) the gas stream containing phosgene obtained in step c) is recycled into the reaction in step a), where e) the pressure of the gas stream containing phosgene obtained in step c) is higher than the pressure of the liquid stream containing phosgene obtained in step b). a) the amine is reacted with phosgene in a reactor above the boiling point of the amine, where a liquid stream containing the isocyanate and a gas stream containing HCl and phosgene are obtained, and b) the gas stream containing HCl and phosgene obtained in step a) is first separated, in a sequence consisting of an isothermal and an adiabatic absorption step, into a gas stream containing HCl and a liquid stream containing phosgene, and c) the liquid stream containing phosgene obtained in step b) is then separated into a gas stream containing phosgene and into a liquid stream, where the temperature of the liquid stream containing phosgene obtained from step b) is raised before entering step c), where the increase in temperature between exiting step b) and entering step c) is between 5-175°C, and d) the gas stream containing phosgene obtained in step c) is recycled into the reaction in step a), where e) the pressure of the gas stream containing phosgene obtained in step c) is higher than the pressure of the liquid stream containing phosgene obtained in step b).
A process for producing a molded rigid polyurethane foam having a ratio of molded foam density (kg/m 3) to Lambda (10°C) (mW/m.K), measured 24 hours after foam production, from 1.65 to 2.15, by injecting into a closed mold cavity a reaction mixture at a packing factor of 1.03 to 1.9 wherein the mold cavity is under a reduced pressure of 300 to 950 mbar and wherein and the reaction mixture comprises: A) an organic polyisocyanate; B) a hydrocarbon blowing agent; C) a polyol composition containing at least one polyol with a functionality of 3 or greater and a hydroxyl number between 300 and 800; D) water present at 0 to 2.5 weight percent of the total polyol formulation; E) catalyst; and F) auxiliary substances and/or additives; wherein the foam has a molded density of 33 to 38 kg/m 3 as measured according to ASTM 1622-88; and wherein the Lambda (10°C) is measured according to ISO 12939-01/DIN 52612. A) an organic polyisocyanate; B) a hydrocarbon blowing agent; C) a polyol composition containing at least one polyol with a functionality of 3 or greater and a hydroxyl number between 300 and 800; D) water present at 0 to 2.5 weight percent of the total polyol formulation; E) catalyst; and F) auxiliary substances and/or additives; wherein the foam has a molded density of 33 to 38 kg/m 3 as measured according to ASTM 1622-88; and wherein the Lambda (10°C) is measured according to ISO 12939-01/DIN 52612.
A chain for use with a sprocket comprising a plurality of links connected together by connecting pins, the links each comprising a body having a pair of apertures (202, 212) for receiving the connecting pins, the apertures being spaced apart by a pitch distance, which is an average distance between contact points of the pins within the apertures of the links, and having a pitch line passing through the pair of apertures (202, 212), the pitch line being defined at the contact points of the pins within the apertures of the link when the links of the chain are in a straight line; and a pair of teeth (205, 215) having outer flanks (204, 214), and inner flanks (206, 216) defining a crotch (203, 213) between the teeth, the link being formed to drivingly contact sprocket teeth of the sprocket on the inner flanks (206, 216) of the link; characterized in that the link comprises: a) a ratio of a distance between the pitch line and a line which contacts the inner flanks (206, 216) at 0.5 times the pitch distance to a product of the pitch distance and the tangent of an effective inner flank angle (φ) between a line tangent to the inner flank (206, 216) of the link at 0.25 times the pitch distance from the vertical centerline of the link and a vertical line intersecting the tangent line, is greater than or equal to 0.850; and b) a ratio of a distance from the pitch line to ends of the teeth (205, 215) to a product of the pitch distance and the tangent of the effective inner flank angle (φ) between a line tangent to the inner flank (206, 216) of the link at 0.25 times the pitch distance from the vertical centerline of the link and a vertical line intersecting the tangent line, is greater than or equal to 1.4; and c) the effective inner flank angle (φ) is less than or equal to 29 degrees, and in that the connecting pins to be received in said apertures (202,212) comprise a pin (208, 218) and a rocker pin (207, 217). a) a ratio of a distance between the pitch line and a line which contacts the inner flanks (206, 216) at 0.5 times the pitch distance to a product of the pitch distance and the tangent of an effective inner flank angle (φ) between a line tangent to the inner flank (206, 216) of the link at 0.25 times the pitch distance from the vertical centerline of the link and a vertical line intersecting the tangent line, is greater than or equal to 0.850; and b) a ratio of a distance from the pitch line to ends of the teeth (205, 215) to a product of the pitch distance and the tangent of the effective inner flank angle (φ) between a line tangent to the inner flank (206, 216) of the link at 0.25 times the pitch distance from the vertical centerline of the link and a vertical line intersecting the tangent line, is greater than or equal to 1.4; and c) the effective inner flank angle (φ) is less than or equal to 29 degrees,
A super critical hydrolysis extraction apparatus comprising: a pressure container comprising a body and a lid coupled to the body to close a space formed therein to accommodate an object; a contact unit configured to open and close the body, while moving the lid forward and backward; and a pipeline unit comprising a supply line for supplying a liquid for filling in the pressure container and a discharge line for discharging the liquid of the pressure container; characterized by a pressing line for additionally supplying to the pressure container accommodating the liquid to apply a pressure to the hydrolysis object. a pressure container comprising a body and a lid coupled to the body to close a space formed therein to accommodate an object; a contact unit configured to open and close the body, while moving the lid forward and backward; and a pipeline unit comprising a supply line for supplying a liquid for filling in the pressure container and a discharge line for discharging the liquid of the pressure container; characterized by a pressing line for additionally supplying to the pressure container accommodating the liquid to apply a pressure to the hydrolysis object.
Measuring apparatus for capturing electrical energy transferred from a charging station (EVSE), wherein a charging cable for forming an electrical connection between a connection point of the charging cable on the charging station (EVSE) and a transfer point of the charging cable on an energy sink can be at least occasionally assigned to the charging station (EVSE), and wherein the charging cable comprises a conductor set having a plurality of conductors (L1, L2), wherein the measuring apparatus comprises: - a first measuring unit for measuring a first electrical power on at least two conductors (L1, L2) at the connection point; - a second measuring unit for measuring at least one second electrical variable at the connection point; characterized by - a determination unit for determining a portion of electrical energy converted into thermal energy along the charging cable from the second electrical variable and for determining the electrical energy transferred at the transfer point on the basis of the first electrical power compensated for by the portion of electrical energy converted into thermal energy along the charging cable, wherein the second electrical variable is in a fixed relationship with respect to an analogue electrical variable relevant to the transferred electrical energy. - a first measuring unit for measuring a first electrical power on at least two conductors (L1, L2) at the connection point; - a second measuring unit for measuring at least one second electrical variable at the connection point; characterized by - a determination unit for determining a portion of electrical energy converted into thermal energy along the charging cable from the second electrical variable and for determining the electrical energy transferred at the transfer point on the basis of the first electrical power compensated for by the portion of electrical energy converted into thermal energy along the charging cable, wherein the second electrical variable is in a fixed relationship with respect to an analogue electrical variable relevant to the transferred electrical energy.
A method performed by a wireless base station for determining when to use full duplex in said wireless base station for communicating in a wireless communication network (1; 1'), wherein said method comprises the steps of: estimating an influence on neighbouring wireless base stations (20, 30) of using full duplex in said wireless base station; deciding whether to use full duplex in said wireless base station or not, based on said estimated influence. estimating an influence on neighbouring wireless base stations (20, 30) of using full duplex in said wireless base station; deciding whether to use full duplex in said wireless base station or not, based on said estimated influence.
Elongated pin for an external modular fixation system for temporary and/or permanent fixation applications to treat bone fractures and to connect two or more bone fragments to each other, comprising an elongated stem extending along a longitudinal axis with a first end portion and an opposite second end portion, said first end portion having a tip for the insertion of the first end portion into a bone, said first end portion having a conical shape with an external thread, forming a conical threaded end portion, characterized in that the ratio between the length of the threaded end portion of the rod and the diameter of the stem is 1-1.2.
A purge control method for a selective catalytic reduction system for a vehicle, the selective catalytic reduction system having a pump for reducing agent, at least one supply line supplying reducing agent to an exhaust line of the vehicle, and a purge fluid suction device, characterized in that the method includes determining a purge duration as a function of a state of fill of the supply line prior to the activation of the purge, and in that the method further includes the updating of the purge duration during purging.