A process for the production of a water-soluble ophthalmic topical preparation containing lutein, said process comprising, in sequence, the following operations: Step 1: a) introducing a predetermined amount of deionized water and, optionally, the components of a buffer system and, also optionally, a predetermined amount of an ophthalmic viscosifying agent into a first stirred vessel, waiting for the complete solubilization of the optional ingredients; Step 2: a) in a second stirred vessel, heating a predetermined amount of vitamin E TPGS up to a temperature of 80-90 °C, and waiting for complete melting thereof; b) bringing the vitamin E TPGS to a temperature of 90-170 °C and adding a predetermined amount of lutein, while continuing stirring until complete dissolution and formation of a homogeneous orange oily solution, consisting exclusively of vitamin E TPGS and lutein; Step 3: a) heating the water or the aqueous solution obtained from operation a) of Step 1 to a temperature of 80-90 °C and adding an aliquot thereof equal to about 10% per volume of the final product, gradually, to said second vessel, while keeping it under stirring; b) once the addition is complete, increasing the stirring speed while maintaining the temperature in the 90-170 °C range until a completely clear and optically homogeneous orange liquid is obtained; Step 4: a) adding the solution of Step 3 to the remaining water or aqueous solution obtained from operation a) of Step 1; b) after verifying that the temperature has fallen down to, or below, 30 °C, adding to the stirred vessel the other water-soluble ingredients of the topical ophthalmic preparation being produced, one at a time and in predetermined quantities, including one or more viscosifying agents and/or mucoadhesives, waiting for the complete solubilization thereof; c) sterilizing the product thus obtained. Step 1: a) introducing a predetermined amount of deionized water and, optionally, the components of a buffer system and, also optionally, a predetermined amount of an ophthalmic viscosifying agent into a first stirred vessel, waiting for the complete solubilization of the optional ingredients; a) introducing a predetermined amount of deionized water and, optionally, the components of a buffer system and, also optionally, a predetermined amount of an ophthalmic viscosifying agent into a first stirred vessel, waiting for the complete solubilization of the optional ingredients; Step 2: a) in a second stirred vessel, heating a predetermined amount of vitamin E TPGS up to a temperature of 80-90 °C, and waiting for complete melting thereof; b) bringing the vitamin E TPGS to a temperature of 90-170 °C and adding a predetermined amount of lutein, while continuing stirring until complete dissolution and formation of a homogeneous orange oily solution, consisting exclusively of vitamin E TPGS and lutein; a) in a second stirred vessel, heating a predetermined amount of vitamin E TPGS up to a temperature of 80-90 °C, and waiting for complete melting thereof; b) bringing the vitamin E TPGS to a temperature of 90-170 °C and adding a predetermined amount of lutein, while continuing stirring until complete dissolution and formation of a homogeneous orange oily solution, consisting exclusively of vitamin E TPGS and lutein; Step 3: a) heating the water or the aqueous solution obtained from operation a) of Step 1 to a temperature of 80-90 °C and adding an aliquot thereof equal to about 10% per volume of the final product, gradually, to said second vessel, while keeping it under stirring; b) once the addition is complete, increasing the stirring speed while maintaining the temperature in the 90-170 °C range until a completely clear and optically homogeneous orange liquid is obtained; a) heating the water or the aqueous solution obtained from operation a) of Step 1 to a temperature of 80-90 °C and adding an aliquot thereof equal to about 10% per volume of the final product, gradually, to said second vessel, while keeping it under stirring; b) once the addition is complete, increasing the stirring speed while maintaining the temperature in the 90-170 °C range until a completely clear and optically homogeneous orange liquid is obtained; Step 4: a) adding the solution of Step 3 to the remaining water or aqueous solution obtained from operation a) of Step 1; b) after verifying that the temperature has fallen down to, or below, 30 °C, adding to the stirred vessel the other water-soluble ingredients of the topical ophthalmic preparation being produced, one at a time and in predetermined quantities, including one or more viscosifying agents and/or mucoadhesives, waiting for the complete solubilization thereof; c) sterilizing the product thus obtained. a) adding the solution of Step 3 to the remaining water or aqueous solution obtained from operation a) of Step 1; b) after verifying that the temperature has fallen down to, or below, 30 °C, adding to the stirred vessel the other water-soluble ingredients of the topical ophthalmic preparation being produced, one at a time and in predetermined quantities, including one or more viscosifying agents and/or mucoadhesives, waiting for the complete solubilization thereof; c) sterilizing the product thus obtained.