A medical procedure mat (10; 110) comprising: a cushioned substrate having a top surface for supporting a patient lying thereon, a bottom surface adapted to be supported by a medical procedure table, an inner portion, and an outer edge portion comprising a head, a foot, and left and right sides; and a first physiological monitoring line for communicating a physiological signal from a physiological sensor associated with the patient, the first physiological monitoring line comprising a guided portion having a proximal end and a distal end, a flexible portion, and an operative coupling between the distal end of the guided portion and the flexible portion, the operative coupling being disposed proximate the outer edge portion of the cushioned substrate, the operative coupling including a mechanism adapted to place a tension on the flexible portion to pull the flexible portion toward the operative coupling, and the operative coupling including a detent position that allows an operator to selectively remove the tension placed on the flexible portion; the guided portion of the first physiological monitoring line being disposed generally along the outer edge portion of the cushioned substrate, the proximal end of the guided portion adapted to be connected to a monitoring device, and the flexible portion being adapted to extend toward the inner portion of the cushioned substrate, the mat (10; 110) further comprising at least a second physiological monitoring line, wherein at least the first and second physiological monitoring lines are housed within a conduit disposed along the outer edge portion of the cushioned substrate, the conduit comprising a hollow space formed in the cushioned substrate for guiding the guided portions of the physiological monitoring lines and a distal opening located near the operative coupling. a cushioned substrate having a top surface for supporting a patient lying thereon, a bottom surface adapted to be supported by a medical procedure table, an inner portion, and an outer edge portion comprising a head, a foot, and left and right sides; a top surface for supporting a patient lying thereon, a bottom surface adapted to be supported by a medical procedure table, an inner portion, and an outer edge portion comprising a head, a foot, and left and right sides; and a first physiological monitoring line for communicating a physiological signal from a physiological sensor associated with the patient, the first physiological monitoring line comprising a guided portion having a proximal end and a distal end, a flexible portion, and an operative coupling between the distal end of the guided portion and the flexible portion, the operative coupling being disposed proximate the outer edge portion of the cushioned substrate, the operative coupling including a mechanism adapted to place a tension on the flexible portion to pull the flexible portion toward the operative coupling, and the operative coupling including a detent position that allows an operator to selectively remove the tension placed on the flexible portion; a guided portion having a proximal end and a distal end, a flexible portion, and an operative coupling between the distal end of the guided portion and the flexible portion, the operative coupling being disposed proximate the outer edge portion of the cushioned substrate, the operative coupling including a mechanism adapted to place a tension on the flexible portion to pull the flexible portion toward the operative coupling, and the operative coupling including a detent position that allows an operator to selectively remove the tension placed on the flexible portion; the guided portion of the first physiological monitoring line being disposed generally along the outer edge portion of the cushioned substrate, the proximal end of the guided portion adapted to be connected to a monitoring device, and the flexible portion being adapted to extend toward the inner portion of the cushioned substrate,