A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: D is selected from the group consisting of: L 1 is C 1 -C 6 alkylene or 2-7-membered heteroalkylene, wherein C 1 -C 6 alkylene or 2-7-membered heteroalkylene is optionally substituted with 1-5 R X; R 1 and R 2 are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy-C 2 -C 6 alkyl, hydroxy-C 2 -C 6 alkyl, or silyloxy-C 2 -C 6 alkyl; A and W are each independently phenyl or 5-6 membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; each R X is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, - NR B C R D, -C NR B R C, -C R D, -C OH, -C OR D, -SR E, -S R D, and -S 2 R D; each R Y is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo-C 1 -C 6 alkoxy, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, - C OR D, -S(R F) m, -S R D, -S 2 R D, and G 1; or 2 R Y groups on adjacent atoms, together with the atoms to which they are attached form a 3-7-membered fused cycloalkyl, 3-7 membered heterocyclyl, aryl, or 5-6 membered heteroaryl, optionally substituted with 1-5 R X; each G 1 is independently C 3 -C 6 cycloalkyl, 4-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl, wherein each C 3 -C 6 cycloalkyl, 4-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl is optionally substituted with 1-3 R Z; each R Z is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, - C OR D, and -S 2 R D; R A is, at each occurrence, independently hydrogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, -C NR B R C, -C R D, or -C OR D; each of R B and R C is independently hydrogen or C 1 -C 6 alkyl; or R B and R C together with the atom to which they are attached form a 3-7-membered heterocyclyl optionally substituted with 1-3 R Z; each R D is independently C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R E is independently hydrogen, C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R F is independently hydrogen, C 1 -C 6 alkyl, halo, or halo-C 1 -C 6 alkyl; and m is 1 when R F is hydrogen or C 1 -C 6 alkyl, 3 when R F is C 1 -C 6 alkyl, or 5 when R F is halo. D is selected from the group consisting of: L 1 is C 1 -C 6 alkylene or 2-7-membered heteroalkylene, wherein C 1 -C 6 alkylene or 2-7-membered heteroalkylene is optionally substituted with 1-5 R X; R 1 and R 2 are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy-C 2 -C 6 alkyl, hydroxy-C 2 -C 6 alkyl, or silyloxy-C 2 -C 6 alkyl; A and W are each independently phenyl or 5-6 membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; each R X is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, - NR B C R D, -C NR B R C, -C R D, -C OH, -C OR D, -SR E, -S R D, and -S 2 R D; each R Y is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo-C 1 -C 6 alkoxy, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, - C OR D, -S(R F) m, -S R D, -S 2 R D, and G 1; or 2 R Y groups on adjacent atoms, together with the atoms to which they are attached form a 3-7-membered fused cycloalkyl, 3-7 membered heterocyclyl, aryl, or 5-6 membered heteroaryl, optionally substituted with 1-5 R X; each G 1 is independently C 3 -C 6 cycloalkyl, 4-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl, wherein each C 3 -C 6 cycloalkyl, 4-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl is optionally substituted with 1-3 R Z; each R Z is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, - C OR D, and -S 2 R D; R A is, at each occurrence, independently hydrogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, -C NR B R C, -C R D, or -C OR D; each of R B and R C is independently hydrogen or C 1 -C 6 alkyl; or R B and R C together with the atom to which they are attached form a 3-7-membered heterocyclyl optionally substituted with 1-3 R Z; each R D is independently C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R E is independently hydrogen, C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R F is independently hydrogen, C 1 -C 6 alkyl, halo, or halo-C 1 -C 6 alkyl; and m is 1 when R F is hydrogen or C 1 -C 6 alkyl, 3 when R F is C 1 -C 6 alkyl, or 5 when R F is halo.