An ultrasonic surgical instrument comprising: (a) a body; (b) an ultrasonic transducer configured to be supported by the body; (c) a shaft extending distally from the body and defining a shaft axis; (d) a waveguide configured to extend distally through the shaft; and (e) an end effector arranged at a distal end of the shaft, wherein the end effector comprises: (i) an ultrasonic blade coupled to a distal end of the waveguide and having a primary blade treatment surface configured to treat tissue, wherein the ultrasonic transducer is configured to drive the waveguide and the ultrasonic blade with ultrasonic energy, and (ii) a clamp arm coupled to the distal end of the shaft, wherein the clamp arm is configured to clamp tissue against the primary blade treatment surface, wherein the shaft and the waveguide are selectively rotatable relative to one another about the shaft axis through a predefined range of angular motion between an assembly state and an operational state, wherein in the assembly state the clamp arm and the primary blade treatment surface are rotationally offset from one another, wherein in the operational state the clamp arm and the primary blade treatment surface are rotationally aligned with one another. wherein the shaft comprises an outer shaft tube and an inner shaft tube configured to be received within the outer shaft tube, wherein the clamp arm is coupled to the outer shaft tube and the waveguide is disposed within the inner shaft tube, wherein the outer shaft tube and the inner shaft tube are rotatable relative to one another through the predefined range of angular motion, wherein the shaft further comprises a connector tube housed in the distal end of the shaft, configured to rotationally couple the outer shaft tube with the inner shaft tube when the surgical instrument is in the operational state. (a) a body; (b) an ultrasonic transducer configured to be supported by the body; (c) a shaft extending distally from the body and defining a shaft axis; (d) a waveguide configured to extend distally through the shaft; and (e) an end effector arranged at a distal end of the shaft, wherein the end effector comprises: (i) an ultrasonic blade coupled to a distal end of the waveguide and having a primary blade treatment surface configured to treat tissue, wherein the ultrasonic transducer is configured to drive the waveguide and the ultrasonic blade with ultrasonic energy, and (ii) a clamp arm coupled to the distal end of the shaft, wherein the clamp arm is configured to clamp tissue against the primary blade treatment surface, (i) an ultrasonic blade coupled to a distal end of the waveguide and having a primary blade treatment surface configured to treat tissue, wherein the ultrasonic transducer is configured to drive the waveguide and the ultrasonic blade with ultrasonic energy, and (ii) a clamp arm coupled to the distal end of the shaft, wherein the clamp arm is configured to clamp tissue against the primary blade treatment surface, wherein the shaft and the waveguide are selectively rotatable relative to one another about the shaft axis through a predefined range of angular motion between an assembly state and an operational state, wherein in the assembly state the clamp arm and the primary blade treatment surface are rotationally offset from one another, wherein in the operational state the clamp arm and the primary blade treatment surface are rotationally aligned with one another. wherein the shaft comprises an outer shaft tube and an inner shaft tube configured to be received within the outer shaft tube, wherein the clamp arm is coupled to the outer shaft tube and the waveguide is disposed within the inner shaft tube, wherein the outer shaft tube and the inner shaft tube are rotatable relative to one another through the predefined range of angular motion, wherein the shaft further comprises a connector tube housed in the distal end of the shaft, configured to rotationally couple the outer shaft tube with the inner shaft tube when the surgical instrument is in the operational state.