A kit for performing a method of testing the risk of a chromosomal abnormality in fetal DNA in a mixed sample of maternal and fetal DNA, wherein the kit comprises components for: (a) preparing a sequencing library from the mixed sample; (b) hybridizing the sequencing library to a pool of double-stranded TArget Capture Sequences (TACS), wherein the pool of TACS comprises sequences that bind to one or more chromosomes of interest comprising a chromosomal abnormality, and wherein: (i) each sequence within the pool is between 100-260 base pairs in length; (ii) each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and (iii) the GC content of the TACS is between 19% and 50%; (c) isolating members of the sequencing library that bind to the TACS to obtain an enriched library; (d) amplifying and sequencing the enriched library; and (e) performing statistical analysis on the enriched library sequences to thereby determine a risk of the chromosomal abnormality in the fetal DNA, wherein the kit comprises a container comprising the pool of TACS, wherein the pool of TACS comprises double-stranded sequences that bind to one or more chromosomes of interest selected from the group of chromosomes 13, 18, 21, X and Y, the chromosomes comprising a chromosomal abnormality, and wherein: each sequence within the pool is between 100-260 base pairs in length; each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and the GC content of the TACS is between 19% and 50 %. (a) preparing a sequencing library from the mixed sample; (b) hybridizing the sequencing library to a pool of double-stranded TArget Capture Sequences (TACS), wherein the pool of TACS comprises sequences that bind to one or more chromosomes of interest comprising a chromosomal abnormality, and wherein: (i) each sequence within the pool is between 100-260 base pairs in length; (ii) each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and (iii) the GC content of the TACS is between 19% and 50%; (i) each sequence within the pool is between 100-260 base pairs in length; (ii) each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and (iii) the GC content of the TACS is between 19% and 50%; (c) isolating members of the sequencing library that bind to the TACS to obtain an enriched library; (d) amplifying and sequencing the enriched library; and (e) performing statistical analysis on the enriched library sequences to thereby determine a risk of the chromosomal abnormality in the fetal DNA, wherein the kit comprises a container comprising the pool of TACS, wherein the pool of TACS comprises double-stranded sequences that bind to one or more chromosomes of interest selected from the group of chromosomes 13, 18, 21, X and Y, the chromosomes comprising a chromosomal abnormality, and wherein: each sequence within the pool is between 100-260 base pairs in length; each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and the GC content of the TACS is between 19% and 50 %. each sequence within the pool is between 100-260 base pairs in length; each sequence within the pool binds to the chromosome(s) of interest at least 150 base pairs away, on both the 5' end and the 3' end, from regions harboring Copy Number Variations (CNVs), Segmental duplications or repetitive DNA elements; and the GC content of the TACS is between 19% and 50 %.