A method in an imaging system, comprising: generating a mask from a set of mask images of an anatomy of a subject, the set of mask images being created from fluoroscopic images acquired during or after injection of a contrast material into the anatomy of the subject; generating a masked image by applying the mask to acquired image data of the anatomy of the subject, including weighting the mask differently inside a user-defined region of interest 'ROI' of the image data than outside the ROI, the weighting inside the ROI being independent of the weighting outside the ROI, wherein the generating of the masked image includes subtracting a first amount of the mask pixel for pixel from a first region inside the ROI and subtracting a second amount of the mask pixel for pixel from a second region outside the ROI, the masked image including the first region and the second region; characterized in that: the first amount and the second amount are each adjusted based on user preference; and the method further comprises: displaying the masked image having both the first region and the second region on a display; and generating a new masked image, comprising subtracting the first amount of the mask pixel for pixel inside a new ROI specified by the user and subtracting the second amount of the mask pixel for pixel outside the new ROI, wherein the generating of the new masked image comprises, responsive to the user touching the display inside a boundary of the first region and dragging the first region from a first location to a new, second location inside the masked image, subtracting a third amount of the mask from the masked image inside the boundary of the first region at the second location, the third amount equal to a difference between the first amount and the second amount. generating a mask from a set of mask images of an anatomy of a subject, the set of mask images being created from fluoroscopic images acquired during or after injection of a contrast material into the anatomy of the subject; generating a masked image by applying the mask to acquired image data of the anatomy of the subject, including weighting the mask differently inside a user-defined region of interest 'ROI' of the image data than outside the ROI, the weighting inside the ROI being independent of the weighting outside the ROI, wherein the generating of the masked image includes subtracting a first amount of the mask pixel for pixel from a first region inside the ROI and subtracting a second amount of the mask pixel for pixel from a second region outside the ROI, the masked image including the first region and the second region; characterized in that: the first amount and the second amount are each adjusted based on user preference; and the method further comprises: displaying the masked image having both the first region and the second region on a display; and generating a new masked image, comprising subtracting the first amount of the mask pixel for pixel inside a new ROI specified by the user and subtracting the second amount of the mask pixel for pixel outside the new ROI, wherein the generating of the new masked image comprises, responsive to the user touching the display inside a boundary of the first region and dragging the first region from a first location to a new, second location inside the masked image, subtracting a third amount of the mask from the masked image inside the boundary of the first region at the second location, the third amount equal to a difference between the first amount and the second amount. the first amount and the second amount are each adjusted based on user preference; and the method further comprises: displaying the masked image having both the first region and the second region on a display; and generating a new masked image, comprising subtracting the first amount of the mask pixel for pixel inside a new ROI specified by the user and subtracting the second amount of the mask pixel for pixel outside the new ROI, wherein the generating of the new masked image comprises, responsive to the user touching the display inside a boundary of the first region and dragging the first region from a first location to a new, second location inside the masked image, subtracting a third amount of the mask from the masked image inside the boundary of the first region at the second location, the third amount equal to a difference between the first amount and the second amount. displaying the masked image having both the first region and the second region on a display; and generating a new masked image, comprising subtracting the first amount of the mask pixel for pixel inside a new ROI specified by the user and subtracting the second amount of the mask pixel for pixel outside the new ROI, wherein the generating of the new masked image comprises, responsive to the user touching the display inside a boundary of the first region and dragging the first region from a first location to a new, second location inside the masked image, subtracting a third amount of the mask from the masked image inside the boundary of the first region at the second location, the third amount equal to a difference between the first amount and the second amount.