A method (A1-A15) for use with an ultrasound scanner, the method comprising: applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method, recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and determining (A9-A14) an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response, characterized in that said determining an estimate value comprises: a) estimating a target power level required to apply a selected target acoustic pressure level to the body-part and/or estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set wherein estimating the target power level and/ or the further target acoustic pressure level is according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent, and/or b) estimating a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and/or c) estimating a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part. applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method, recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and determining (A9-A14) an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response, a) estimating a target power level required to apply a selected target acoustic pressure level to the body-part and/or estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set wherein estimating the target power level and/ or the further target acoustic pressure level is according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent, and/or b) estimating a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and/or c) estimating a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part.