An air-conditioning apparatus comprising: a refrigeration cycle in which a compressor, a refrigerant passage of at least one intermediate heat exchanger (31, 33) operating as a condenser or an evaporator, an expansion device, and a heat source side heat exchanger are connected by pipes and through which a refrigerant circulates; a heat medium circuit in which a heat medium passage of the intermediate heat exchanger (31, 33), a heat medium circulating device (41, 42), a use side heat exchanger, and a heat medium flow control device disposed corresponding to the use side heat exchanger are connected by pipes and through which a heat medium circulates; a controller (201, 202) configured to control the heat medium flow control device in order to adjust the flow rate of the heat medium flowing through the use side heat exchanger; a first heat medium temperature detecting device configured to detect the temperature of the heat medium flowing into the use side heat exchanger; and a second heat medium temperature detecting device disposed corresponding to the use side heat exchanger, the second heat medium temperature detecting device being configured to detect the temperature of the heat medium flowing out of the use side heat exchanger, wherein the controller (201, 202) is configured to calculate a heat medium temperature difference between a detected value of the first heat medium temperature detecting device and a detected value of the second heat medium temperature detecting device for the use side heat exchanger which is operating, and control the heat medium flow control device such that the heat medium temperature difference reaches a target heat medium temperature difference, and characterized in that the controller (201, 202) is configured to detect, when the detected value of the first heat medium temperature detecting device deviates from a predetermined range and in this case the controller is configured to change the target heat medium temperature difference and to control the heat medium flow control device corresponding to the use side heat exchanger, which is operating, such that the heat medium temperature difference reaches the changed target heat medium temperature difference. a refrigeration cycle in which a compressor, a refrigerant passage of at least one intermediate heat exchanger (31, 33) operating as a condenser or an evaporator, an expansion device, and a heat source side heat exchanger are connected by pipes and through which a refrigerant circulates; a heat medium circuit in which a heat medium passage of the intermediate heat exchanger (31, 33), a heat medium circulating device (41, 42), a use side heat exchanger, and a heat medium flow control device disposed corresponding to the use side heat exchanger are connected by pipes and through which a heat medium circulates; a controller (201, 202) configured to control the heat medium flow control device in order to adjust the flow rate of the heat medium flowing through the use side heat exchanger; a first heat medium temperature detecting device configured to detect the temperature of the heat medium flowing into the use side heat exchanger; and a second heat medium temperature detecting device disposed corresponding to the use side heat exchanger, the second heat medium temperature detecting device being configured to detect the temperature of the heat medium flowing out of the use side heat exchanger, wherein the controller (201, 202) is configured to calculate a heat medium temperature difference between a detected value of the first heat medium temperature detecting device and a detected value of the second heat medium temperature detecting device for the use side heat exchanger which is operating, and control the heat medium flow control device such that the heat medium temperature difference reaches a target heat medium temperature difference, and characterized in that the controller (201, 202) is configured to detect, when the detected value of the first heat medium temperature detecting device deviates from a predetermined range and in this case the controller is configured to change the target heat medium temperature difference and to control the heat medium flow control device corresponding to the use side heat exchanger, which is operating, such that the heat medium temperature difference reaches the changed target heat medium temperature difference.