A compound of formula II or II', or a tautomer thereof, a pharmaceutically acceptable salt, solvate, or ester thereof: wherein: X is O, S or NR; Y is -OR, -O-(CH 2) m COOR, -O-(CH 2) m CON 2, -N 2, -N SOR or -N SO 2 R, wherein the groups bound to the nitrogen atom may be in Z- or E- configuration; R 1 and R 2 are independently hydrogen, or halogen; R 3, R 4, R 5, R 6, R 7, R 8, R 9 and R 10 are independently hydrogen, halogen, azido, nitro, cyano, aliphatic, alkylaryl, aralkyl, aryl, heteroalkyl, alkylheteroaryl, heterocyclyl, heteroaryl, OR, N 2, SR, -O(CH 2) m N C (CH 2)pR, -O(CH 2) m OC (CH 2)pR, -O(CH 2) m C (CH 2) p N 2, -O(CH 2) m C (CH 2) p OR, -O(CH 2) m N C (CH 2) p OR, -O(CH 2) m N C (CH 2) p N 2, -O(CH 2) m OC (CH 2) p OR, -O(CH 2) m OC (CH 2) p N 2, -NR(CH 2) m N C (CH 2) p R, -NR(CH 2) m OC (CH 2) p R, -NR m C p N 2, -NR(CH 2) m C (CH 2) p OR, -NR(CH 2) m N C (CH 2) p OR, -NR(CH 2) m N C (CH 2) p N 2, -NR(CH 2) m OC (CH 2) p OR, -NR(CH 2) m OC (CH 2) p N 2, -(CH 2) m N C (CH 2) p R, -(CH 2) m OC (CH 2) p R, -(CH 2) m C (CH 2) p N 2, -(CH 2) m C (CH 2)pOR, -(CH 2) m N C (CH 2) p OR, -(CH 2) m N C (CH 2) p N 2, -(CH 2) m OC p OR, -(CH 2) m OC (CH 2) p N 2, -(CH 2) m N 3, -O(CH 2) m N 3 -(CH 2) m N 2, -(CH 2) m OR, -(CH 2) m S (CH 2) p R, -(CH 2) m S 2 (CH 2) p R, - (CH 2) m SO 2 (CH 2) p N 2, or -(CH 2) m N SO 2 (CH 2) p R; and each R is independently R 11, hydrogen, aliphatic, amino, azido, cyano, nitro, alkylamino, dialkylamino, OH, alkoxy, carbonylamino, aminocarbonyl, alkoxycarbonyl, carbonyloxy, carboxy, acyl, aryl, alkaryl, arylalkyl including benzyl, heteroalkyl, heteroaryl, heterocyclyl, or a protecting group selected from a group consisting of ethoxymethyl, methoxymethyl, tert-butyldimethyl silyl, phenyldimethylsilyl, trimethylsilyl, 2-trimethylsilylethoxymethyl, 2-trimethylsilylethyl; and benzyl; or two R on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclic or heteroaryl ring; wherein where a group contains more than one R substituent; wherein R is optionally substituted, and each R can be the same or different; R 11 is the group: where Z is an inorganic or organic counterion; m and p are independently 0, 1, 2, 3, 4 or 5; and wherein in formula II', when X is O, then at least one of R 5, R 6, R 7, R 8, R 9 or R 10 is not hydrogen. X is O, S or NR; Y is -OR, -O-(CH 2) m COOR, -O-(CH 2) m CON 2, -N 2, -N SOR or -N SO 2 R, wherein the groups bound to the nitrogen atom may be in Z- or E- configuration; R 1 and R 2 are independently hydrogen, or halogen; R 3, R 4, R 5, R 6, R 7, R 8, R 9 and R 10 are independently hydrogen, halogen, azido, nitro, cyano, aliphatic, alkylaryl, aralkyl, aryl, heteroalkyl, alkylheteroaryl, heterocyclyl, heteroaryl, OR, N 2, SR, -O(CH 2) m N C (CH 2)pR, -O(CH 2) m OC (CH 2)pR, -O(CH 2) m C (CH 2) p N 2, -O(CH 2) m C (CH 2) p OR, -O(CH 2) m N C (CH 2) p OR, -O(CH 2) m N C (CH 2) p N 2, -O(CH 2) m OC (CH 2) p OR, -O(CH 2) m OC (CH 2) p N 2, -NR(CH 2) m N C (CH 2) p R, -NR(CH 2) m OC (CH 2) p R, -NR m C p N 2, -NR(CH 2) m C (CH 2) p OR, -NR(CH 2) m N C (CH 2) p OR, -NR(CH 2) m N C (CH 2) p N 2, -NR(CH 2) m OC (CH 2) p OR, -NR(CH 2) m OC (CH 2) p N 2, -(CH 2) m N C (CH 2) p R, -(CH 2) m OC (CH 2) p R, -(CH 2) m C (CH 2) p N 2, -(CH 2) m C (CH 2)pOR, -(CH 2) m N C (CH 2) p OR, -(CH 2) m N C (CH 2) p N 2, -(CH 2) m OC p OR, -(CH 2) m OC (CH 2) p N 2, -(CH 2) m N 3, -O(CH 2) m N 3 -(CH 2) m N 2, -(CH 2) m OR, -(CH 2) m S (CH 2) p R, -(CH 2) m S 2 (CH 2) p R, - (CH 2) m SO 2 (CH 2) p N 2, or -(CH 2) m N SO 2 (CH 2) p R; and each R is independently R 11, hydrogen, aliphatic, amino, azido, cyano, nitro, alkylamino, dialkylamino, OH, alkoxy, carbonylamino, aminocarbonyl, alkoxycarbonyl, carbonyloxy, carboxy, acyl, aryl, alkaryl, arylalkyl including benzyl, heteroalkyl, heteroaryl, heterocyclyl, or a protecting group selected from a group consisting of ethoxymethyl, methoxymethyl, tert-butyldimethyl silyl, phenyldimethylsilyl, trimethylsilyl, 2-trimethylsilylethoxymethyl, 2-trimethylsilylethyl; and benzyl; or two R on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclic or heteroaryl ring; wherein where a group contains more than one R substituent; wherein R is optionally substituted, and each R can be the same or different; R 11 is the group: where Z is an inorganic or organic counterion; m and p are independently 0, 1, 2, 3, 4 or 5; and wherein in formula II', when X is O, then at least one of R 5, R 6, R 7, R 8, R 9 or R 10 is not hydrogen.