A patient physiological information monitoring system, comprising: a plurality of patient monitoring devices that monitor physiological information from a patient and generate corresponding physiological signals; and a physiological information analyzer that processes the monitored physiological information and determines whether a physiological change is a clinically significant event or an artifact, the physiological information analyzer including: at least one receiver that receives the physiological signals from the patient monitoring devices; a signal correlator that generates morphograms from pairs of the received physiological signals, wherein each morphogram is a mapping of one physiological signal of the respective pair to the other physiological signal of the respective pair; a signature generator that applies a wavelet decomposition to each morphogram to compute a signature for each morphogram; and a decision component that compares the morphogram signatures within and across sampling intervals and determines if a physiological change is a clinically significant change or an artifact, wherein the decision component determines the physiological change is an artifact if the shape perturbation is only in a subset of signatures with at least one common signal and wherein the decision component determines the physiological change is a clinically significant change if the shape perturbation is in the signatures generated from signals related to the physiological change. a plurality of patient monitoring devices that monitor physiological information from a patient and generate corresponding physiological signals; and a physiological information analyzer that processes the monitored physiological information and determines whether a physiological change is a clinically significant event or an artifact, the physiological information analyzer including: at least one receiver that receives the physiological signals from the patient monitoring devices; a signal correlator that generates morphograms from pairs of the received physiological signals, wherein each morphogram is a mapping of one physiological signal of the respective pair to the other physiological signal of the respective pair; a signature generator that applies a wavelet decomposition to each morphogram to compute a signature for each morphogram; and a decision component that compares the morphogram signatures within and across sampling intervals and determines if a physiological change is a clinically significant change or an artifact, wherein the decision component determines the physiological change is an artifact if the shape perturbation is only in a subset of signatures with at least one common signal and wherein the decision component determines the physiological change is a clinically significant change if the shape perturbation is in the signatures generated from signals related to the physiological change. at least one receiver that receives the physiological signals from the patient monitoring devices; a signal correlator that generates morphograms from pairs of the received physiological signals, wherein each morphogram is a mapping of one physiological signal of the respective pair to the other physiological signal of the respective pair; a signature generator that applies a wavelet decomposition to each morphogram to compute a signature for each morphogram; and a decision component that compares the morphogram signatures within and across sampling intervals and determines if a physiological change is a clinically significant change or an artifact, wherein the decision component determines the physiological change is an artifact if the shape perturbation is only in a subset of signatures with at least one common signal and wherein the decision component determines the physiological change is a clinically significant change if the shape perturbation is in the signatures generated from signals related to the physiological change.