A 5-aromatic alkynyl-substituted benzamide compound having a structure represented by the following general formula I, and racemate, R-isomer, S-isomer, pharmaceutically acceptable salt or mixture thereof: X is CH or N; R 1 is selected from the following group: hydrogen, halogen, C1-C6 alkyl, halogen substituted C1-C6 alkyl, cyano; R 2 and R 3 are each independently select from the group consisting of hydrogen, substituted or unsubstituted phenyl, substituted or unsubstituted 3-7 membered heteroaryl, substituted or unsubstituted 5-7 membered aryl-methylene, 3-7 membered heterocyclyl-methylene, while each heterocyclyl independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; and R 2 and R 3 are not simultaneously hydrogen; or R 2 and R 3 together with the attached N atom form a group selected from the group consisting of substituted or unsubstituted 5-20 membered hetero spirocyclic ring, or substituted or unsubstituted 4-20 membered fused heterocyclic ring; wherein the substituted means one or more hydrogen atoms of the group are substituted by substituents selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, halogen-substituted C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, cyano, nitro, amino, hydroxy, hydroxymethyl, carboxy, mercapto, sulfonyl, C6-C10 aryl, and 3-12 membered heterocyclyl; wherein the hetero spirocyclic ring, fused heterocyclic ring or heterocyclyl each independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; wherein the A ring is selected from the group consisting of wherein R 4, R 5, R 6 and R 7 each represents 1-4 substituents on the heteroring, and each substituent is independently selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, amino, hydroxy, and R 8 each represents 1-4 substituents on the heteroring, and each substituent is independently selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, hydroxy OR wherein the A ring is selected from the group consisting of substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted isoxazolyl, or substituted or unsubstituted indazolyl; wherein the substitutent is selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, amino, hydroxy and when R 1 is H, A ring is substituted or unsubstituted 5 membered aromatic heterocyclic ring; the halogen is F, Cl, Br or I. X is CH or N; R 1 is selected from the following group: hydrogen, halogen, C1-C6 alkyl, halogen substituted C1-C6 alkyl, cyano; R 2 and R 3 are each independently select from the group consisting of hydrogen, substituted or unsubstituted phenyl, substituted or unsubstituted 3-7 membered heteroaryl, substituted or unsubstituted 5-7 membered aryl-methylene, 3-7 membered heterocyclyl-methylene, while each heterocyclyl independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; and R 2 and R 3 are not simultaneously hydrogen; or R 2 and R 3 together with the attached N atom form a group selected from the group consisting of substituted or unsubstituted 5-20 membered hetero spirocyclic ring, or substituted or unsubstituted 4-20 membered fused heterocyclic ring; wherein the substituted means one or more hydrogen atoms of the group are substituted by substituents selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, halogen-substituted C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, cyano, nitro, amino, hydroxy, hydroxymethyl, carboxy, mercapto, sulfonyl, C6-C10 aryl, and 3-12 membered heterocyclyl; wherein the hetero spirocyclic ring, fused heterocyclic ring or heterocyclyl each independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; wherein the A ring is selected from the group consisting of wherein R 4, R 5, R 6 and R 7 each represents 1-4 substituents on the heteroring, and each substituent is independently selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, amino, hydroxy, and R 8 each represents 1-4 substituents on the heteroring, and each substituent is independently selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, hydroxy OR wherein the A ring is selected from the group consisting of substituted or unsubstituted pyridyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted isoxazolyl, or substituted or unsubstituted indazolyl; wherein the substitutent is selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, amino, hydroxy and when R 1 is H, A ring is substituted or unsubstituted 5 membered aromatic heterocyclic ring; the halogen is F, Cl, Br or I.