A system for delivery of a therapeutic agent through a catheter to target tissue, the system comprising: an injection catheter having a head at a distal end, a proximal end opposite the distal end, and a shaft extending between the distal and proximal ends; a plurality of needles disposed in the catheter head movably between a retracted position in which the needles are located within the catheter head and an extended position in which front ends of the needles project from the catheter head through openings formed therein, each of the plurality of needles being hollow so as to have a needle passage; a multi-lumen hose upon which the needles are mounted, the multi-lumen hose longitudinally movably supported within the catheter and having a plurality of individual passages, each of the plurality of individual passages in fluid communication with a respective one of the needle passages; an activation mechanism on the catheter shaft for longitudinally moving the multi-lumen hose to selectively deploy the needles into the extended position and retracted position, the activation mechanism operatively associated with the catheter shaft and the multi-lumen hose; characterized by an automated delivery device having a controller for controlling rate of delivery and timing of release of the therapeutic agent and at least one chamber containing the therapeutic agent, each of the at least one chamber having an outlet in fluid communication with one of the individual passages for transmitting the therapeutic agent to the needles for injection into the target tissue, and wherein the activation mechanism is including a movable part including a threaded thrust plunger, wherein the multi-lumen hose is affixed to the thrust plunger at the catheter proximal end, therapeutic agent inlets and channels providing fluid flow communication between the therapeutic agent inlets and the corresponding injection needles and a bore which extends into a guide volume within the catheter shaft, a stationary part affixed to the catheter shaft and including a cylinder in which the thrust plunger is slidable, wherein the cylinder has connected thereto the catheter shaft, a rotatable threaded nut captively supported on the stationary part and threadably engaged with the thrust plunger to cause the thrust plunger part to slide within the cylinder when the nut is rotated to thereby move the multi-lumen hose and mounted needles distally and proximally within the catheter shaft. an injection catheter having a head at a distal end, a proximal end opposite the distal end, and a shaft extending between the distal and proximal ends; a plurality of needles disposed in the catheter head movably between a retracted position in which the needles are located within the catheter head and an extended position in which front ends of the needles project from the catheter head through openings formed therein, each of the plurality of needles being hollow so as to have a needle passage; a multi-lumen hose upon which the needles are mounted, the multi-lumen hose longitudinally movably supported within the catheter and having a plurality of individual passages, each of the plurality of individual passages in fluid communication with a respective one of the needle passages; an activation mechanism on the catheter shaft for longitudinally moving the multi-lumen hose to selectively deploy the needles into the extended position and retracted position, the activation mechanism operatively associated with the catheter shaft and the multi-lumen hose; characterized by an automated delivery device having a controller for controlling rate of delivery and timing of release of the therapeutic agent and at least one chamber containing the therapeutic agent, each of the at least one chamber having an outlet in fluid communication with one of the individual passages for transmitting the therapeutic agent to the needles for injection into the target tissue, and wherein the activation mechanism is including a movable part including a threaded thrust plunger, wherein the multi-lumen hose is affixed to the thrust plunger at the catheter proximal end, therapeutic agent inlets and channels providing fluid flow communication between the therapeutic agent inlets and the corresponding injection needles and a bore which extends into a guide volume within the catheter shaft, a stationary part affixed to the catheter shaft and including a cylinder in which the thrust plunger is slidable, wherein the cylinder has connected thereto the catheter shaft, a rotatable threaded nut captively supported on the stationary part and threadably engaged with the thrust plunger to cause the thrust plunger part to slide within the cylinder when the nut is rotated to thereby move the multi-lumen hose and mounted needles distally and proximally within the catheter shaft. a movable part including a threaded thrust plunger, wherein the multi-lumen hose is affixed to the thrust plunger at the catheter proximal end, therapeutic agent inlets and channels providing fluid flow communication between the therapeutic agent inlets and the corresponding injection needles and a bore which extends into a guide volume within the catheter shaft, a stationary part affixed to the catheter shaft and including a cylinder in which the thrust plunger is slidable, wherein the cylinder has connected thereto the catheter shaft, a rotatable threaded nut captively supported on the stationary part and threadably engaged with the thrust plunger to cause the thrust plunger part to slide within the cylinder when the nut is rotated to thereby move the multi-lumen hose and mounted needles distally and proximally within the catheter shaft.