An operating handle with a feedback of guidewire/catheter advancement resistance for a vascular intervention robot comprising a sliding guide rail, a fixing base plate, a connecting rod, an operation rod, a rotary driving device, and a motor, wherein a rotor of the motor is connected with the sliding guide rail through a slider; the connecting rod has a first end and a second end, the first end is provided with the operation rod; the connecting rod passes through the rotary driving device; the rotary driving device, the sliding guide rail, and a stator of the motor are arranged on the fixing base plate; the rotary driving device comprises a fixing base, a rotary encoder, and a rotary driving piece, the rotary encoder is provided on the fixing base; characterized in that the operating handle further comprises a pressure sensing device, the motor is a linear motor; the pressure sensing device is connected with the sliding guide rail through the slider; the pressure sensitive device and a rotor of the linear motor are configured to reciprocate along the sliding guide rail; the second end of the connecting rod is connected with the rotor of the linear motor through a strain gauge; and the connecting rod passes through the pressure sensing device and the rotary driving device in sequence; the rotary driving device further comprises a rotary driving rod, and the rotary driving rod is connected with a rotor of the rotary encoder; the rotary driving piece is fixed to the connecting rod and has two ends provided with connecting holes; and the rotary driving piece is connected with the rotary driving rod through the connecting holes; and the connecting rod is configured to drive the rotary driving piece to rotate so as to drive the rotary encoder to rotate through the rotary driving rod; wherein the rotary driving piece is slidable on the rotary driving rod through the connecting holes. the rotary driving device, the sliding guide rail, and a stator of the motor are arranged on the fixing base plate; the rotary driving device comprises a fixing base, a rotary encoder, and a rotary driving piece, the rotary encoder is provided on the fixing base; characterized in that the operating handle further comprises a pressure sensing device, the motor is a linear motor; the pressure sensing device is connected with the sliding guide rail through the slider; the pressure sensitive device and a rotor of the linear motor are configured to reciprocate along the sliding guide rail; the second end of the connecting rod is connected with the rotor of the linear motor through a strain gauge; and the connecting rod passes through the pressure sensing device and the rotary driving device in sequence; the rotary driving device further comprises a rotary driving rod, and the rotary driving rod is connected with a rotor of the rotary encoder; the rotary driving piece is fixed to the connecting rod and has two ends provided with connecting holes; and the rotary driving piece is connected with the rotary driving rod through the connecting holes; and the connecting rod is configured to drive the rotary driving piece to rotate so as to drive the rotary encoder to rotate through the rotary driving rod; wherein the rotary driving piece is slidable on the rotary driving rod through the connecting holes.