Machine tool for machining pieces made of wood or at least partially wood, plastic, glass, marble, composite materials, or the like, comprising a base comprising a supporting surface and a blocking system for supporting and blocking the piece to be machined, a crossbeam placed above said base and movable relative thereto along a first direction, a machining head coupled with said crossbeam and movable relative thereto along a second direction, perpendicular to said first direction, and along a third direction, perpendicular to said first and second direction, a machining aggregate for performing machining operations on said pieces, said machining aggregate being removably coupled with said machining head, a pneumatic actuation system for the actuation of said machining aggregate, associated with said machining head and having an air supply line, and wherein said machining head has at its end a flat interface with said machining aggregate up to which said air supply line is guided, said machine being characterized in that said pneumatic actuation system comprises a pressure control unit installed on said air supply line and configured for: - blowing air through said air supply line to supply compressed air to said machining aggregate to perform a first operation, and - sucking air through said air supply line to generate vacuum for said machining aggregate to perform a second operation, the machine further comprising a piston-cylinder assembly, having a cylinder and a piston, wherein said cylinder has a first and a second chamber separated by said piston, and wherein, when the pressure control unit supplies compressed air into said first chamber through said air supply line, said piston is extracted, so as to carry out said first operation, and when the pressure control unit generates a vacuum in said first chamber through said air supply line, said piston is retracted, so as to carry out said second operation. a base comprising a supporting surface and a blocking system for supporting and blocking the piece to be machined, a crossbeam placed above said base and movable relative thereto along a first direction, a machining head coupled with said crossbeam and movable relative thereto along a second direction, perpendicular to said first direction, and along a third direction, perpendicular to said first and second direction, a machining aggregate for performing machining operations on said pieces, said machining aggregate being removably coupled with said machining head, a pneumatic actuation system for the actuation of said machining aggregate, associated with said machining head and having an air supply line, and wherein said machining head has at its end a flat interface with said machining aggregate up to which said air supply line is guided, said machine being characterized in that said pneumatic actuation system comprises a pressure control unit installed on said air supply line and configured for: - blowing air through said air supply line to supply compressed air to said machining aggregate to perform a first operation, and - sucking air through said air supply line to generate vacuum for said machining aggregate to perform a second operation, the machine further comprising - blowing air through said air supply line to supply compressed air to said machining aggregate to perform a first operation, and - sucking air through said air supply line to generate vacuum for said machining aggregate to perform a second operation, the machine further comprising a piston-cylinder assembly, having a cylinder and a piston, wherein said cylinder has a first and a second chamber separated by said piston, and wherein, when the pressure control unit supplies compressed air into said first chamber through said air supply line, said piston is extracted, so as to carry out said first operation, and when the pressure control unit generates a vacuum in said first chamber through said air supply line, said piston is retracted, so as to carry out said second operation.