mhurhangee/ep-ind-claims huggingface dataset:
A method for sample analysis comprising: (a) incubating a sample comprising a target analyte with: (i) a first conjugate comprising a binding agent and a first splint oligonucleotide, and (ii) a second conjugate comprising a binding agent and a second splint oligonucleotide, under conditions suitable for binding of the binding agents of the first and second conjugates to the target analyte, to produce a product, wherein the binding agents of the first and second conjugates are affinity-selected polyclonal antibodies, and the affinity-selected polyclonal antibodies are split into a first portion which is conjugated to the first splint oligonucleotide and a second portion which is conjugated to the second splint oligonucleotide; (b) incubating at least some of the product of step (a) with: (i) a set of probes that produces a ligatable circle only when the probes are hybridized to the first and second splint oligonucleotides; and (ii) a ligase; to produce a reaction mix comprising covalently closed circular molecules; (c) treating at least some of the reaction mix of step (b) with an exonuclease to terminate the ligation and degrade any nucleic acid that is not a covalently closed circular molecule; and (d) after step (c), quantifying the amount of covalently closed circular molecules produced in step (b). (a) incubating a sample comprising a target analyte with: (i) a first conjugate comprising a binding agent and a first splint oligonucleotide, and (ii) a second conjugate comprising a binding agent and a second splint oligonucleotide, under conditions suitable for binding of the binding agents of the first and second conjugates to the target analyte, to produce a product, wherein the binding agents of the first and second conjugates are affinity-selected polyclonal antibodies, and the affinity-selected polyclonal antibodies are split into a first portion which is conjugated to the first splint oligonucleotide and a second portion which is conjugated to the second splint oligonucleotide; (i) a first conjugate comprising a binding agent and a first splint oligonucleotide, and (ii) a second conjugate comprising a binding agent and a second splint oligonucleotide, (b) incubating at least some of the product of step (a) with: (i) a set of probes that produces a ligatable circle only when the probes are hybridized to the first and second splint oligonucleotides; and (ii) a ligase; to produce a reaction mix comprising covalently closed circular molecules; (i) a set of probes that produces a ligatable circle only when the probes are hybridized to the first and second splint oligonucleotides; and (ii) a ligase; (c) treating at least some of the reaction mix of step (b) with an exonuclease to terminate the ligation and degrade any nucleic acid that is not a covalently closed circular molecule; and (d) after step (c), quantifying the amount of covalently closed circular molecules produced in step (b).
A system for sequestering a target analyte believed to be present in a bulk liquid specimen, said system comprising: a. a bulk specimen reservoir defining a first interior volume for receiving said bulk liquid specimen suspected of containing said target analyte; b. a plurality of paramagnetic particles configured to specifically bind to said target analyte suspected of being present in said bulk liquid specimen; c. at least one vertex defining a second internal volume, said at least one vertex being detachably interconnectable with said bulk specimen reservoir such that the interior of said vertex and said interior of said bulk specimen reservoir define a specimen chamber assembly; and d. at least one magnetic capsule releasably engageable with dedicated ones of said at least one vertex, said at least one magnetic capsule configured to project a magnetic field within the second interior of said at least one vertex and magnetically sequester a portion of said paramagnetic particles distributed within said bulk liquid sample containing said target analyte of interest. a. a bulk specimen reservoir defining a first interior volume for receiving said bulk liquid specimen suspected of containing said target analyte; b. a plurality of paramagnetic particles configured to specifically bind to said target analyte suspected of being present in said bulk liquid specimen; c. at least one vertex defining a second internal volume, said at least one vertex being detachably interconnectable with said bulk specimen reservoir such that the interior of said vertex and said interior of said bulk specimen reservoir define a specimen chamber assembly; and d. at least one magnetic capsule releasably engageable with dedicated ones of said at least one vertex, said at least one magnetic capsule configured to project a magnetic field within the second interior of said at least one vertex and magnetically sequester a portion of said paramagnetic particles distributed within said bulk liquid sample containing said target analyte of interest.
Device for the treatment by a pulsed electric field of a product intended to circulate through this device, this device comprising first and second electrodes (4, 6) forming parallel plates between which a treatment zone is defined, and also comprising a pulse generator electrically connected to at least said first electrode so as to be able to apply a pulsed electric field in the treatment zone through which said product will flow, the pulsed electric field having a direction approximately orthogonal to a principal product flow direction between the two electrodes, said device also comprising a product inlet conduit into said treatment zone and a product outlet conduit through which the product exits from the treatment zone, characterised in that said first electrode is electrically connected to the pulse generator through either the inlet conduit or the outlet conduit (26, 30), arranged in contact with this first electrode.
A method, comprising: receiving, by an operating system, OS, executing on a processor of a device, a uniform resource locator, URL and a cryptogram from a contactless card associated with an account; launching, by the operating system responsive to receiving the URL, an application associated with the contactless card; transmitting, by the application, the cryptogram to an authentication server; receiving, by the application, a decryption result from the authentication server indicating the authentication server decrypted the cryptogram; characterised by transmitting, by the application based on the decryption result, a request for a one-time passcode, OTP comprising an identifier to the URL; receiving, by the device, the OTP from an OTP generator at the URL; receiving, by the application, an input value; comparing, by the application, the input value to a copy of the OTP received from the OTP generator; determining, by the application, that the comparison results in a match; and displaying, by the application based on the determination that the comparison results in the match, one or more attributes of the account on the device. receiving, by an operating system, OS, executing on a processor of a device, a uniform resource locator, URL and a cryptogram from a contactless card associated with an account; launching, by the operating system responsive to receiving the URL, an application associated with the contactless card; transmitting, by the application, the cryptogram to an authentication server; receiving, by the application, a decryption result from the authentication server indicating the authentication server decrypted the cryptogram; characterised by transmitting, by the application based on the decryption result, a request for a one-time passcode, OTP comprising an identifier to the URL; receiving, by the device, the OTP from an OTP generator at the URL; receiving, by the application, an input value; comparing, by the application, the input value to a copy of the OTP received from the OTP generator; determining, by the application, that the comparison results in a match; and displaying, by the application based on the determination that the comparison results in the match, one or more attributes of the account on the device.
A method of extending at least one nucleic acid template comprising a repeating A/T-rich segment, the method comprising performing a nucleic acid amplification reaction in an aqueous solution comprising the at least one nucleic acid template; at least one polymerase; at least one primer; magnesium; and NTPs in an AT/GC molar ratio in the range of about 10 to about 40; and wherein the repeating A/T-rich segment is: (i) a homopolymeric segment comprising at least 10 A residues, at least 10 T residues, or at least 10 U residues, wherein the at least 10 A, T, or U residues are consecutive or interrupted once by one to three other nucleotides; or (ii) a segment comprising (T n A) m, (AT n) m, (TA n) m, or (A n T) m, wherein n is 2 or greater and m is such that the length of the repeating A/T-rich segment is 10 or more residues. (i) a homopolymeric segment comprising at least 10 A residues, at least 10 T residues, or at least 10 U residues, wherein the at least 10 A, T, or U residues are consecutive or interrupted once by one to three other nucleotides; or (ii) a segment comprising (T n A) m, (AT n) m, (TA n) m, or (A n T) m, wherein n is 2 or greater and m is such that the length of the repeating A/T-rich segment is 10 or more residues.
Method for determining a pressure of a fluid with the aid of a pressure measurement cell, comprising a main body, a membrane which is arranged at the front on the main body and can be deformed by the pressure of the fluid, a first temperature sensor which can detect a first temperature (T 1) of the membrane, and a second temperature sensor which can detect a second temperature (T 2) of the main body, wherein a temperature difference between the first temperature (T 1) and the second temperature is specified, wherein the pressure measurement cell is designed as a ceramic pressure measurement cell with a membrane electrode arranged on the membrane and a measuring electrode arranged opposite the membrane electrode on the main body, and the distance between the membrane electrode and the measuring electrode changes due to a change of pressure of the fluid acting on the membrane, so that a change in capacitance can be detected and the pressure measurement cell outputs a measured value, characterised in that as a function of a temporal change of the temperature difference the measured value of the pressure measurement cell is output directly or as a function of a value of the temperature difference this measured value is corrected and output as output value, so that as a function of the magnitude of the change in the temperature difference a distinction can be made between a dynamic, a quasi-static and a static phase and an adapted measured value correction is carried out as a function of the respectively applicable phase.
An adaptive analytical instrument, comprising a computer controlled target-analyte permeation testing instrument programmed to periodically measure target-analyte transmission rate throughout a permeation testing period employing a sensing period for each measurement, and adjusting duration of the sensing period of future target-analyte transmission rate measurements based upon the value of at least one previous target-analyte transmission rate measurement, characterized in that the value of at least one previous target-analyte transmission rate measurement is the mean or median of a plurality of immediately preceding measurements, and in that the duration of future sensing periods is: (i) set at a decreased duration when the value of the at least one previous target-analyte transmission rate measurement is above a predetermined higher threshold value, and (ii) set at an increased duration when the value of the at least one previous target-analyte transmission rate measurement is below a lower predetermined threshold value, and (iii) allowed to remain or reset to an initial sensing period when the value of the at least one previous target-analyte transmission rate measurement is more than the lower predetermined threshold value and less than the higher threshold value. (i) set at a decreased duration when the value of the at least one previous target-analyte transmission rate measurement is above a predetermined higher threshold value, and (ii) set at an increased duration when the value of the at least one previous target-analyte transmission rate measurement is below a lower predetermined threshold value, and (iii) allowed to remain or reset to an initial sensing period when the value of the at least one previous target-analyte transmission rate measurement is more than the lower predetermined threshold value and less than the higher threshold value.
A driving method for a metering pump which includes an eccentric mechanism converting a revolving motion of a motor into a revolving and reciprocating motion of a plunger of the metering pump, and makes a constant liquid delivery by sucking and discharging a liquid through variations in the cubic volume of a cylinder of the metering pump caused by the revolving and reciprocating motion of the plunger, wherein a variable relative-comparison mode is provided in which a discharge period of the metering pump is set to be longer than a suction period of the metering pump, and the revolution speed of the motor is controlled so that the travelling speed of the plunger is kept constant during the discharge period, and wherein if the number of revolutions of the motor is equal to or less than a predetermined value, then the variable relative-comparison mode is utilized, and if the number of revolutions of the motor is more than the predetermined value, then a constant revolution mode is utilized in which the suction period of the metering pump is set to be equal to the discharge period of the metering pump and the motor is set to make a constant-speed revolving motion during the suction period and the discharge period. wherein a variable relative-comparison mode is provided in which a discharge period of the metering pump is set to be longer than a suction period of the metering pump, and the revolution speed of the motor is controlled so that the travelling speed of the plunger is kept constant during the discharge period, and wherein if the number of revolutions of the motor is equal to or less than a predetermined value, then the variable relative-comparison mode is utilized, and if the number of revolutions of the motor is more than the predetermined value, then a constant revolution mode is utilized in which the suction period of the metering pump is set to be equal to the discharge period of the metering pump and the motor is set to make a constant-speed revolving motion during the suction period and the discharge period. if the number of revolutions of the motor is equal to or less than a predetermined value, then the variable relative-comparison mode is utilized, and if the number of revolutions of the motor is more than the predetermined value, then a constant revolution mode is utilized in which the suction period of the metering pump is set to be equal to the discharge period of the metering pump and the motor is set to make a constant-speed revolving motion during the suction period and the discharge period.
An electronic testing device, comprising: a housing, which is sized and shaped to fit snugly over a connector at an end of a cable, the connector containing first electrical contacts; second electrical contacts within the housing, which are configured and positioned to mate with the first electrical contacts when the housing is fitted over the connector; and test circuitry, which is contained within the housing and configured to receive electrical power from an internal battery, the test circuitry coupled to the second electrical contacts and configured to test a functionality of the cable, wherein the electronic testing device is configured to connect, via the cable, to an electronic system at an opposite end of the cable, the electronic system comprising a console having front end circuits and sockets, and wherein the electronic testing device is configured to test a functionality of the console by closing loop on signals that are transmitted from the console, analyzing the signals to detect potential faults in the console, and sending the analyzed signals back to the console. a housing, which is sized and shaped to fit snugly over a connector at an end of a cable, the connector containing first electrical contacts; second electrical contacts within the housing, which are configured and positioned to mate with the first electrical contacts when the housing is fitted over the connector; and test circuitry, which is contained within the housing and configured to receive electrical power from an internal battery, the test circuitry coupled to the second electrical contacts and configured to test a functionality of the cable, wherein the electronic testing device is configured to connect, via the cable, to an electronic system at an opposite end of the cable, the electronic system comprising a console having front end circuits and sockets, and wherein the electronic testing device is configured to test a functionality of the console by closing loop on signals that are transmitted from the console, analyzing the signals to detect potential faults in the console, and sending the analyzed signals back to the console.
A converter (200, 300, 400, 800) applied to a photovoltaic power generation system, comprising: a controller (202, 301, 401, 801), a plurality of input ports, a power circuit (201, 302, 402, 802), wherein the power circuit is a direct current-direct current conversion circuit, a direct current-alternating current conversion circuit, or a connection control circuit, and at least one switching transistor (203, 303, 403, 803), wherein the converter supports access of at least two photovoltaic units (204, 205, 304, 305, 404, 804) via the input ports, the input ports are arranged such that the at least two photovoltaic units, when connected to the input ports, are connected in series inside the converter by using the switching transistor; and the controller is configured to: when a startup instruction is received and a heartbeat instruction is received, control the switching transistor to be connected; and when a shutdown instruction is received or a heartbeat instruction is lost within a preset time period, control the switching transistor to be disconnected, so that any two photovoltaic units connected in series are disconnected and control the power circuit to stop power conversion, or limit an output voltage of the power circuit to be less than a preset voltage value, or limit an output current of the power circuit to be less than a preset current value. the converter supports access of at least two photovoltaic units (204, 205, 304, 305, 404, 804) via the input ports, the input ports are arranged such that the at least two photovoltaic units, when connected to the input ports, are connected in series inside the converter by using the switching transistor; and the controller is configured to: when a startup instruction is received and a heartbeat instruction is received, control the switching transistor to be connected; and when a shutdown instruction is received or a heartbeat instruction is lost within a preset time period, control the switching transistor to be disconnected, so that any two photovoltaic units connected in series are disconnected and control the power circuit to stop power conversion, or limit an output voltage of the power circuit to be less than a preset voltage value, or limit an output current of the power circuit to be less than a preset current value.
A curable composition for forming an encapsulant film, wherein the composition comprises: (a) a polyolefin polymer; (b) an organic peroxide; (c) a silane coupling agent, wherein the silane coupling agent is selected from the group consisting of γ-chloropropyl trimethoxysilane, vinyl trimethoxysilane, vinyl triethoxysilane, vinyl-tris-(β-methoxy)silane, allyltrimethoxysilane, γ-methacryloxypropyl trimethoxysilane, β-(3,4-ethoxy-cyclohexyl)ethyl trimethoxysilane, γ-glycidoxypropyl trimethoxysilane, γ-mercaptopropyltrimethoxysilane, γ-aminopropyl trimethoxysilane, N-β-(aminoethyl)- γ-aminopropyl trimethoxysilane, and 3-(tri methoxysilyl)propyl methacrylate; and (d) a co-agent comprising a silane compound of formula: wherein subscript n is an integer from 0 to 2; each R1 is independently a (C 2 -C 4)alkenyl, H, a (C 1 -C 6)alkyl, phenyl, O-Me, O-Et and each R2 is independently a (C 2 -C 4)alkenyl, H, a (C 1 -C 6)alkyl, phenyl, O-Me, O-Et, or R1, wherein the silane compound of formula is selected from the group consisting of: tetravinylsilane; trivinylmethylsilane; trivinylmethoxysilane; trivinylethoxysilane; tetraallylsilane; triallylmethylsilane; and combinations thereof. (a) a polyolefin polymer; (b) an organic peroxide; (c) a silane coupling agent, wherein the silane coupling agent is selected from the group consisting of γ-chloropropyl trimethoxysilane, vinyl trimethoxysilane, vinyl triethoxysilane, vinyl-tris-(β-methoxy)silane, allyltrimethoxysilane, γ-methacryloxypropyl trimethoxysilane, β-(3,4-ethoxy-cyclohexyl)ethyl trimethoxysilane, γ-glycidoxypropyl trimethoxysilane, γ-mercaptopropyltrimethoxysilane, γ-aminopropyl trimethoxysilane, N-β-(aminoethyl)- γ-aminopropyl trimethoxysilane, and 3-(tri methoxysilyl)propyl methacrylate; and (d) a co-agent comprising a silane compound of formula: wherein subscript n is an integer from 0 to 2; each R1 is independently a (C 2 -C 4)alkenyl, H, a (C 1 -C 6)alkyl, phenyl, O-Me, O-Et and each R2 is independently a (C 2 -C 4)alkenyl, H, a (C 1 -C 6)alkyl, phenyl, O-Me, O-Et, or R1, wherein the silane compound of formula is selected from the group consisting of: tetravinylsilane; trivinylmethylsilane; trivinylmethoxysilane; trivinylethoxysilane; tetraallylsilane; triallylmethylsilane; and combinations thereof.
A biomedical implant, comprising: a tubular scaffold comprising a plurality of polymer struts, wherein the polymer struts are interconnected and define a plurality of deformable cells, wherein the polymer struts have an average thickness of no more than 150 μm, and wherein the polymer struts comprise a fiber-reinforced polymer composite material, the fiber- reinforced polymer composite material comprising a bioabsorbable polymer material and a reinforcement fiber material, said reinforcement fiber material being bioabsorbable glass, and wherein said reinforcement fiber materials are longitudinally aligned along a center axis of the polymer struts, and wherein a pharmaceutical agent is incorporated to the tubular scaffold, said pharmaceutical agent being a macrolide immunosuppressant. a tubular scaffold comprising a plurality of polymer struts, wherein the polymer struts are interconnected and define a plurality of deformable cells, wherein the polymer struts have an average thickness of no more than 150 μm, and wherein the polymer struts comprise a fiber-reinforced polymer composite material, the fiber- reinforced polymer composite material comprising a bioabsorbable polymer material and a reinforcement fiber material, said reinforcement fiber material being bioabsorbable glass, and wherein said reinforcement fiber materials are longitudinally aligned along a center axis of the polymer struts, and wherein the polymer struts have an average thickness of no more than 150 μm, and wherein the polymer struts comprise a fiber-reinforced polymer composite material, the fiber- reinforced polymer composite material comprising a bioabsorbable polymer material and a reinforcement fiber material, said reinforcement fiber material being bioabsorbable glass, and wherein said reinforcement fiber materials are longitudinally aligned along a center axis of the polymer struts, and wherein a pharmaceutical agent is incorporated to the tubular scaffold, said pharmaceutical agent being a macrolide immunosuppressant.