A compound of Formula or a pharmaceutically acceptable salt thereof, wherein R 1 is 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, said aryl and heteroaryl ring is unsubstituted, or independently mono-, di-, or trisubstituted on any carbon ring atom with R 7; R2 is CH or N; R3 is CH or N; R4 is CH or N; R5 is CH, N, or CR 8 R6 is 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, said aryl and heteroaryl ring is unsubstituted, or independently mono-, di-, or trisubstituted on any carbon ring atom with R 9; R 7, each time in which it occurs, is independently -C(NR 11)N(R 11) 2, -N(R 11) 2, -CN or -C 1-6 alkyl, wherein alkyl is unsubstituted or substituted at any carbon atom with-NH 2; R 8 is hydrogen, halogen or C 1-6 alkyl; R9, each time in which it occurs, is independently -OCF 3, halogen, -C R 10, -C 1-6 alkyl, -N(R 12) 2, or -CF 3; R 10 is a 6-membered heterocycle; R 11, each time in which it occurs, is hydrogen or C 1-6 alkyl; and R 12, each time in which it occurs, is hydrogen or C 1-6 alkyl. R 1 is 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, said aryl and heteroaryl ring is unsubstituted, or independently mono-, di-, or trisubstituted on any carbon ring atom with R 7; 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, R2 is CH or N; R3 is CH or N; R4 is CH or N; R5 is CH, N, or CR 8 R6 is 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, said aryl and heteroaryl ring is unsubstituted, or independently mono-, di-, or trisubstituted on any carbon ring atom with R 9; 1) an aryl ring, or 2) a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and the heteroaryl ring is selected from the group consisting of: a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, a) a 5- or 6-membered unsaturated monocyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, b) an 9- or 10-membered unsaturated bicyclic ring with 1, 2, 3, or 4 heteroatom ring atoms selected from the group consisting of N, O or S, R 7, each time in which it occurs, is independently -C(NR 11)N(R 11) 2, -N(R 11) 2, -CN or -C 1-6 alkyl, wherein alkyl is unsubstituted or substituted at any carbon atom with-NH 2; R 8 is hydrogen, halogen or C 1-6 alkyl; R9, each time in which it occurs, is independently -OCF 3, halogen, -C R 10, -C 1-6 alkyl, -N(R 12) 2, or -CF 3; R 10 is a 6-membered heterocycle; R 11, each time in which it occurs, is hydrogen or C 1-6 alkyl; and R 12, each time in which it occurs, is hydrogen or C 1-6 alkyl.