An image processing system, the system comprising: a computer, wherein the computer receives a plurality of image scans acquired over time, the image scans being of an area of interest of a patient to which a contrast agent was administered; wherein the computer uses registration logic to register the image scans to a common coordinate system to compensate for motion in the image scans; wherein the computer uses selection logic to process the image scans and automatically select locations at which observed reference information is compared to modeled reference information to obtain plausible reference information; wherein the observed reference information includes a time-concentration curve representing an observed curve (202, 212) and the modeled reference information includes a time-concentration curve representing a model curve (204, 214), said model curve (204, 214) accounting for characteristics of the contrast agent, location of an injection site for the contrast agent, and the area of interest of the patient; wherein the selection logic measures a similarity between the observed curve (202, 212) and the corresponding model curve (204, 214); wherein the selection logic determines a similarity measure as a ratio of an area under a difference curve, which corresponds to an amount of disagreement between the observed curve (202, 212) and the model curve (204, 214), to an area under the observed curve (202, 212), and wherein the computer uses correction logic to determine if the plausible reference information includes motion artifacts, and if the plausible reference information is determined to include motion artifacts, the correction logic performs one of rejecting the plausible reference information and modifying the plausible reference information. a computer, wherein the computer receives a plurality of image scans acquired over time, the image scans being of an area of interest of a patient to which a contrast agent was administered; wherein the computer uses registration logic to register the image scans to a common coordinate system to compensate for motion in the image scans; wherein the computer uses selection logic to process the image scans and automatically select locations at which observed reference information is compared to modeled reference information to obtain plausible reference information; wherein the observed reference information includes a time-concentration curve representing an observed curve (202, 212) and the modeled reference information includes a time-concentration curve representing a model curve (204, 214), said model curve (204, 214) accounting for characteristics of the contrast agent, location of an injection site for the contrast agent, and the area of interest of the patient; wherein the selection logic measures a similarity between the observed curve (202, 212) and the corresponding model curve (204, 214); wherein the selection logic determines a similarity measure as a ratio of an area under a difference curve, which corresponds to an amount of disagreement between the observed curve (202, 212) and the model curve (204, 214), to an area under the observed curve (202, 212), and wherein the computer uses correction logic to determine if the plausible reference information includes motion artifacts, and if the plausible reference information is determined to include motion artifacts, the correction logic performs one of rejecting the plausible reference information and modifying the plausible reference information.