A compound of formula, including any stereochemically isomeric form thereof, wherein R 1 is hydrogen, hydroxy, C 1-4 alkyl, mono- or di(C 1-4 alkyl)amino, or Heterocyclyl 1; R 2 is hydrogen or C 1-4 alkyl; R 3 is C 1-4 alkyl, halo, C 3-6 cycloalkyl, mono- or di(C 1-4 alkyl)amino, or Heterocyclyl 2; R 4 is hydrogen, C 1-6 alkyl, hydroxy, or halo; Heterocyclyl 1 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; wherein each Heterocyclyl 1 is optionally substituted with one or two substituents selected from C 1-4 alkyl, hydroxy, halo, polyhaloC 1-4 alkyl, C 1-4 alkyloxycarbonyl, amino, C 1-4 alkylaminocarbonyl, or C 1-4 alkylsulfonyl; Heterocyclyl 2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; wherein each Heterocyclyl 2 is optionally substituted with one or two substituents selected from C 1-4 alkyl, hydroxy, halo, polyhaloC 1-4 alkyl, C 1-4 alkyloxycarbonyl, amino, C 1-4 alkyloxycarbonylamino, or C 1-4 alkylsulfonyl; Het is selected from furanyl, thiophenyl, pyrazolyl, oxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolyl, cinnolinyl, quinazolinyl, quinoxalinyl, 1,5-naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, 1,8-naphthyridinyl, pyrido[2,3-d]pyrimidinyl, pyrido[3,2-d]pyrimidinyl, 9H-purinyl, thiazolo[5,4-d]pyrimidinyl, 7H-pyrrolo[2,3-d]pyrimidinyl, oxazolo[5,4-d]pyrimidinyl, thieno[2,3-d]-pyrimidinyl, or thieno[3,2-d]pyrimidinyl; wherein each Het is optionally substituted with one, two or three substitutents each independently selected from halo, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkylthio, hydroxy, amino, mono- or di(C 1-4 alkyl)amino, hydroxycarbonyl, C 1-4 alkyloxycarbonyl, C 1-4 alkylsulfonylamino, aminocarbonyl, trifluoromethyl, C 1-4 alkyloxycarbonylamino, di(C 1-4 alkyloxycarbonyl)amino, C 1-4 alkylsulfonylaminocarbonyl, C 1-4 alkylamino carbonyl, C 1-4 alkyloxyC 1-6 alkyloxycarbonylamino, di(C 1-4 alkyl)aminosulfonyl-aminocarbonyl, C 3-6 cycloalkylsulfonylaminocarbonyl, HO-NH-(C=NH)-; oxazolyl or triazolyl each optionally substituted with one or two C 1-4 alkyl; or a pharmaceutically acceptable acid addition salt thereof. R 1 is hydrogen, hydroxy, C 1-4 alkyl, mono- or di(C 1-4 alkyl)amino, or Heterocyclyl 1; R 2 is hydrogen or C 1-4 alkyl; R 3 is C 1-4 alkyl, halo, C 3-6 cycloalkyl, mono- or di(C 1-4 alkyl)amino, or Heterocyclyl 2; R 4 is hydrogen, C 1-6 alkyl, hydroxy, or halo; Heterocyclyl 1 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; wherein each Heterocyclyl 1 is optionally substituted with one or two substituents selected from C 1-4 alkyl, hydroxy, halo, polyhaloC 1-4 alkyl, C 1-4 alkyloxycarbonyl, amino, C 1-4 alkylaminocarbonyl, or C 1-4 alkylsulfonyl; Heterocyclyl 2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl; wherein each Heterocyclyl 2 is optionally substituted with one or two substituents selected from C 1-4 alkyl, hydroxy, halo, polyhaloC 1-4 alkyl, C 1-4 alkyloxycarbonyl, amino, C 1-4 alkyloxycarbonylamino, or C 1-4 alkylsulfonyl; Het is selected from furanyl, thiophenyl, pyrazolyl, oxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolyl, cinnolinyl, quinazolinyl, quinoxalinyl, 1,5-naphthyridinyl, 1,6-naphthyridinyl, 1,7-naphthyridinyl, 1,8-naphthyridinyl, pyrido[2,3-d]pyrimidinyl, pyrido[3,2-d]pyrimidinyl, 9H-purinyl, thiazolo[5,4-d]pyrimidinyl, 7H-pyrrolo[2,3-d]pyrimidinyl, oxazolo[5,4-d]pyrimidinyl, thieno[2,3-d]-pyrimidinyl, or thieno[3,2-d]pyrimidinyl; wherein each Het is optionally substituted with one, two or three substitutents each independently selected from halo, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkylthio, hydroxy, amino, mono- or di(C 1-4 alkyl)amino, hydroxycarbonyl, C 1-4 alkyloxycarbonyl, C 1-4 alkylsulfonylamino, aminocarbonyl, trifluoromethyl, C 1-4 alkyloxycarbonylamino, di(C 1-4 alkyloxycarbonyl)amino, C 1-4 alkylsulfonylaminocarbonyl, C 1-4 alkylamino carbonyl, C 1-4 alkyloxyC 1-6 alkyloxycarbonylamino, di(C 1-4 alkyl)aminosulfonyl-aminocarbonyl, C 3-6 cycloalkylsulfonylaminocarbonyl, HO-NH-(C=NH)-; oxazolyl or triazolyl each optionally substituted with one or two C 1-4 alkyl; or a pharmaceutically acceptable acid addition salt thereof.