A compound of Formula I or pharmaceutically acceptable salts thereof, wherein, R 1 is C 1-8 alkyl, C 1-8 halo alkyl or -O-R 4, wherein R 4 is C 1-5 alkyl, halo C 1-5 alkyl, C 3-7 cycloalkyl, halo C 3-7 cycloalkyl or C 3-7 cycloalkyl-methyl; R 2 is C 3-8 cycloalkyl, 4-7 membered heterocycloalkyl containing one or two heteroatoms selected from a group consisting of N, O and S or 4-7 membered heterocycloalkenyl containing one or two heteroatoms selected from a group consisting of N, O and S, which may optionally be substituted with 1-3 substituents independently selected from the following group: C 1-8 alkyl, halo C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, halo C 3-8 cycloalkoxy, C 1-8 alkoxy-C 1-8 alkyl, hydroxy-C 1-8 alkyl, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, halogen, cyano, cyano-C 1-8 alkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, C 3-8 cycloalkyl-amino, substituted or unsubstituted 4-7 membered heterocyclyl, -CONR 5 R 6, -COR 5, -SO 2 R 5 and -NR 5 SO 2 R 6, wherein R 5 and R 6 are independently hydrogen, C 1-8 alkyl, halo C 1-8 alkyl, C 3-8 cycloalkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, cyano-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl or di- (C 1-8 alkyl)-amino-C 1-8 alkyl; R 3 is -SO 2 R 7, wherein R 7 is isopropyl, sec-butyl or isobutyl; X is a chemical bond or O; Z 1 is N or C-R 10, wherein R 10 is hydrogen, halogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy or cyano; Z 2 is C-R 11, wherein R 11 is hydrogen, C 1-8 alkyl, halogen or cyano, wherein R 11 and R 2 may optionally togetherform a ring with the carbon atoms to which they are attached, the ring may be optionally substituted with 1-3 substituents independently selected from the group consisting of oxo, C 1-8 alkyl, halo C 1-8 alkyl, C 1-8 alkoxy, halo C 1-8 alkoxy, C 3-8 cycloalkyl, halo C 3-8 cycloalkyl, C 3-8 cycloalkoxy, halo C 3-8 cycloalkoxy, C 1-8 alkoxy-C 1-8 alkyl, hydroxy-C 1-8 alkyl, amino-C 1-8 alkyl, carboxyl-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, halogen, hydroxy, cyano, cyano-C 1-8 alkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl) amino, C 3-8 cycloalkyl-amino, substituted or unsubstituted aromatic group, substituted or unsubstituted heteroaromatic group, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclyl-alkyl, -(CH 2) n CONR 12 R 13, -COR 12, -SO 2 R 12 and -NR 12 SO 2 R 13, wherein n is an integer of 0-8, R 12 and R 13 are independently hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, cyano C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl or di- (C 1-8 alkyl)-amino-C 1-8 alkyl; Z 3 is N, Z 4 is N-R 14, Z 5 is CH; wherein R 14 is hydrogen, alkyl, haloalkyl, C 3-8 cycloalkyl, halo-C 3-8 cycloalkyl or 4-6 membered heterocyclyl. wherein, R 1 is C 1-8 alkyl, C 1-8 halo alkyl or -O-R 4, wherein R 4 is C 1-5 alkyl, halo C 1-5 alkyl, C 3-7 cycloalkyl, halo C 3-7 cycloalkyl or C 3-7 cycloalkyl-methyl; R 2 is C 3-8 cycloalkyl, 4-7 membered heterocycloalkyl containing one or two heteroatoms selected from a group consisting of N, O and S or 4-7 membered heterocycloalkenyl containing one or two heteroatoms selected from a group consisting of N, O and S, which may optionally be substituted with 1-3 substituents independently selected from the following group: C 1-8 alkyl, halo C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, halo C 3-8 cycloalkoxy, C 1-8 alkoxy-C 1-8 alkyl, hydroxy-C 1-8 alkyl, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, halogen, cyano, cyano-C 1-8 alkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, C 3-8 cycloalkyl-amino, substituted or unsubstituted 4-7 membered heterocyclyl, -CONR 5 R 6, -COR 5, -SO 2 R 5 and -NR 5 SO 2 R 6, wherein R 5 and R 6 are independently hydrogen, C 1-8 alkyl, halo C 1-8 alkyl, C 3-8 cycloalkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, cyano-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl or di- (C 1-8 alkyl)-amino-C 1-8 alkyl; R 3 is -SO 2 R 7, wherein R 7 is isopropyl, sec-butyl or isobutyl; X is a chemical bond or O; Z 1 is N or C-R 10, wherein R 10 is hydrogen, halogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy or cyano; Z 2 is C-R 11, wherein R 11 is hydrogen, C 1-8 alkyl, halogen or cyano, wherein R 11 and R 2 may optionally togetherform a ring with the carbon atoms to which they are attached, the ring may be optionally substituted with 1-3 substituents independently selected from the group consisting of oxo, C 1-8 alkyl, halo C 1-8 alkyl, C 1-8 alkoxy, halo C 1-8 alkoxy, C 3-8 cycloalkyl, halo C 3-8 cycloalkyl, C 3-8 cycloalkoxy, halo C 3-8 cycloalkoxy, C 1-8 alkoxy-C 1-8 alkyl, hydroxy-C 1-8 alkyl, amino-C 1-8 alkyl, carboxyl-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, halogen, hydroxy, cyano, cyano-C 1-8 alkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl) amino, C 3-8 cycloalkyl-amino, substituted or unsubstituted aromatic group, substituted or unsubstituted heteroaromatic group, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclyl-alkyl, -(CH 2) n CONR 12 R 13, -COR 12, -SO 2 R 12 and -NR 12 SO 2 R 13, wherein n is an integer of 0-8, R 12 and R 13 are independently hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, amino, C 1-8 alkyl-amino, di (C 1-8 alkyl)-amino, cyano C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl or di- (C 1-8 alkyl)-amino-C 1-8 alkyl; Z 3 is N, Z 4 is N-R 14, Z 5 is CH; wherein R 14 is hydrogen, alkyl, haloalkyl, C 3-8 cycloalkyl, halo-C 3-8 cycloalkyl or 4-6 membered heterocyclyl.