mhurhangee/ep-ind-claims huggingface dataset:
Recombinant L-threonine- or L-tryptophan-producing microorganisms of the family Enterobacteriaceae, which contain an overexpressed tig gene which codes for the trigger factor TF, the parent strains used for the measures of overexpression of the tig gene already possessing the capacity to accumulate at least 0.25 g/l L-threonine or L-tryptophan in at most 120 hours in the cell and/or in the nutrient medium or fermentation broth, where a) the microorganisms are produced by transformation, transduction, conjugation or a combination of these methods with a vector that contains the tig gene, an allele of this gene or parts thereof which have the activity of the trigger factor TF, and optionally a promoter; and/or b) in the microorganisms the copy number of the tig gene or of the alleles has been increased by at least 1 in comparison to the microorganisms that are non-recombinant for the tig gene; and/or c) to achieve the enhancement, the promoter and regulation region or the ribosome binding site is mutated upstream of the tig gene or expression cassettes or promoters are installed upstream of the tig gene. a) the microorganisms are produced by transformation, transduction, conjugation or a combination of these methods with a vector that contains the tig gene, an allele of this gene or parts thereof which have the activity of the trigger factor TF, and optionally a promoter; and/or b) in the microorganisms the copy number of the tig gene or of the alleles has been increased by at least 1 in comparison to the microorganisms that are non-recombinant for the tig gene; and/or c) to achieve the enhancement, the promoter and regulation region or the ribosome binding site is mutated upstream of the tig gene or expression cassettes or promoters are installed upstream of the tig gene.
A recombinant adeno-associated virus comprising a DNA encoding a DUX4 miRNA comprising the miRNA antisense guide strand sequence set out in SEQ ID NO: 8152, SEQ ID NO: 8147, or SEQ ID NO: 8145, wherein the recombinant adeno-associated virus lacks rep and cap genes. SEQ ID NO: 8152, SEQ ID NO: 8147, or SEQ ID NO: 8145,
Tooling for balancing a turbine engine module in a balancing machine, said module having at least one stator housing and a rotor having a shaft with a longitudinal axis A and at least one blade stage which is connected to a longitudinal end portion of said shaft and which is surrounded by said stator housing, said tooling having at least: - a balancing frame, having bearings (26, 28) designed to receive and to guide the shaft and blade stage of the rotor, - first and second means (30, 32) designed to be attached to said stator housing; - third and fourth means (34, 36) provided on said frame, to attach said first and second means (30, 32), respectively, to said frame, - fifth means for transporting the frame; characterized in that: - the position of at least one of said bearings is adjustable relative to said frame; - the position of at least one of said third and fourth means (34, 36) is adjustable relative to said frame; and in that said tooling also comprises sixth means (84, 94) for supporting the frame, comprising a first and second support provided on said frame and designed to cooperate equally well with the balancing machine and with the fifth means for transporting the frame, in order to support said frame in said fifth means for transport and in said balancing machine. - a balancing frame, having bearings (26, 28) designed to receive and to guide the shaft and blade stage of the rotor, - first and second means (30, 32) designed to be attached to said stator housing; - third and fourth means (34, 36) provided on said frame, to attach said first and second means (30, 32), respectively, to said frame, - fifth means for transporting the frame; - the position of at least one of said bearings is adjustable relative to said frame; - the position of at least one of said third and fourth means (34, 36) is adjustable relative to said frame;
Apparatus, comprising: a first interface, which is configured to accept a plurality of Magnetic Resonance Imaging data points of a cardiac chamber of a heart, acquired over multiple phases of at least one cardiac cycle; a second interface, which is configured to accept from an intra-cardiac probe electrical potential measurements acquired at respective points on a surface of the cardiac chamber; and a processor, which is configured to construct a simulated surface of the cardiac chamber by processing the MRI data points, and to overlay the electrical potential measurements on the simulated surface constructed from the MRI data points, so as to produce a map of the parameter on the surface, and identify anatomical features of the heart, wherein the first interface is configured to acquire the MRI data points in a region-of-interest around the intra-cardiac probe while the probe is present in the cardiac chamber, and wherein the processor is configured to update the simulated surface in the region-of-interest in real time based on the acquired MRI data points. a first interface, which is configured to accept a plurality of Magnetic Resonance Imaging data points of a cardiac chamber of a heart, acquired over multiple phases of at least one cardiac cycle; a second interface, which is configured to accept from an intra-cardiac probe electrical potential measurements acquired at respective points on a surface of the cardiac chamber; and a processor, which is configured to construct a simulated surface of the cardiac chamber by processing the MRI data points, and to overlay the electrical potential measurements on the simulated surface constructed from the MRI data points, so as to produce a map of the parameter on the surface, and identify anatomical features of the heart, wherein the first interface is configured to acquire the MRI data points in a region-of-interest around the intra-cardiac probe while the probe is present in the cardiac chamber, and wherein the processor is configured to update the simulated surface in the region-of-interest in real time based on the acquired MRI data points.
A wastewater treatment process in which a first neutralizing agent is added into sulfuric acid-acidic wastewater containing aluminum, magnesium, and manganese to adjust the pH of the wastewater to 4.0 to 6.0 to separate an aluminum hydroxide precipitate and obtain a solution after dealumination, then a second neutralizing agent to adjust the pH to 8.0 to 9.0 and a oxidizing agent are added to the solution after dealumination to separate a manganese precipitate and obtain a solution after demanganization, and then a third neutralizing agent is added to the solution after demanganization to adjust the pH to 7.0 to 8.5 to obtain a wastewater precipitate and effluent wastewater, comprising, producing magnesium oxide, which is used for the first to third neutralizing agents to be added, through any steps from to: a calcium separation step of concentrating effluent wastewater obtained by separating aluminum and manganese from sulfuric acid-acidic wastewater, and precipitating and separating calcium contained in the effluent wastewater as a calcium sulfate; a magnesium crystallization step of further concentrating a solution obtained through the calcium separation step, and precipitating and separating magnesium contained in the solution as a magnesium sulfate; a roasting step of roasting the magnesium sulfate separated in the magnesium crystallization step together with a reducing agent, and obtaining a magnesium oxide and sulfurous acid gas; and a washing step of washing the magnesium oxide obtained in the roasting step. a calcium separation step of concentrating effluent wastewater obtained by separating aluminum and manganese from sulfuric acid-acidic wastewater, and precipitating and separating calcium contained in the effluent wastewater as a calcium sulfate; a magnesium crystallization step of further concentrating a solution obtained through the calcium separation step, and precipitating and separating magnesium contained in the solution as a magnesium sulfate; a roasting step of roasting the magnesium sulfate separated in the magnesium crystallization step together with a reducing agent, and obtaining a magnesium oxide and sulfurous acid gas; and a washing step of washing the magnesium oxide obtained in the roasting step.
A process for the preparation of a copolymer of ethylene and a di- or higher functional (meth) acrylate in a tubular reactor, comprising the steps of: injecting ethylene at a pressure of 100 MPa to 350 MPa into the reactor from a high pressure compressor and injecting the (meth)acrylate at a pressure of 100 MPa to 350 MPa into the reactor from a high pressure pump, wherein the high pressure pump comprises - a pump suction chamber for receiving a medium to be compressed; - a cylinder for receiving the medium to be compressed from the pump suction chamber; - an outlet for discharging a compressed medium from the cylinder, - a seal fixed to the inner wall of the cylinder at an end of the cylinder distal to the outlet and - a plunger movable in the cylinder by sliding through the seal, wherein a leakage gap is present along the plunger and the leakage gap is fluidly connected to the pump suction chamber. - a pump suction chamber for receiving a medium to be compressed; - a cylinder for receiving the medium to be compressed from the pump suction chamber; - an outlet for discharging a compressed medium from the cylinder, - a seal fixed to the inner wall of the cylinder at an end of the cylinder distal to the outlet and - a plunger movable in the cylinder by sliding through the seal,
Method to make a phosphorus modified zeolite comprising the following steps in this order, a) providing a zeolite comprising at least one ten members ring in the structure, optionally steaming said zeolite, b) mixing said zeolite of step a) with at least a component selected among one or more binders and shaping additives, then shaping said mixture, c) optionally making a ion-exchange, d) steaming the shaped catalyst, optionally before step c), e) introducing phosphorus on the catalyst to introduce at least 0.1 wt% of phosphorus, said introduction being made by impregnation or chemical vapor deposition, f) optionally introducing a alkaline earth or rare earth metal in the form of an oxide, optionally simultaneously with step e), g) optionally washing the catalyst, h) optionally calcinating the catalyst, i) steaming the catalyst, also referred to as the equilibration step. a) providing a zeolite comprising at least one ten members ring in the structure, optionally steaming said zeolite, b) mixing said zeolite of step a) with at least a component selected among one or more binders and shaping additives, then shaping said mixture, c) optionally making a ion-exchange, d) steaming the shaped catalyst, optionally before step c), e) introducing phosphorus on the catalyst to introduce at least 0.1 wt% of phosphorus, said introduction being made by impregnation or chemical vapor deposition, f) optionally introducing a alkaline earth or rare earth metal in the form of an oxide, optionally simultaneously with step e), g) optionally washing the catalyst, h) optionally calcinating the catalyst, i) steaming the catalyst, also referred to as the equilibration step.
A welding system comprising: a weld cable, an enclosure having a first radio module and a second radio module disposed therein; a first cable coupled to the enclosure; and a first antenna electrically coupled to the first radio module and mounted to the first cable at a first location along the first cable outside the enclosure, wherein the first radio module is configured to communicate along a first wireless communications channel via the first antenna, a second antenna electrically coupled to the second radio module, wherein the second radio module is configured to communicate along a second wireless communication channel via the second antenna, a communication line coupled to the first radio module and to the first antenna; and a sleeve disposed about the communication line and an external portion of the first cable, wherein the external portion of the first cable is outside the enclosure between the enclosure and the first location, wherein the communication line is configured to be at least partially integrated with the weld cable outside of the enclosure, and wherein the enclosure encompasses components of a welding power unit, a welding device or a gas supply system. a weld cable, an enclosure having a first radio module and a second radio module disposed therein; a first cable coupled to the enclosure; and a first antenna electrically coupled to the first radio module and mounted to the first cable at a first location along the first cable outside the enclosure, wherein the first radio module is configured to communicate along a first wireless communications channel via the first antenna, a second antenna electrically coupled to the second radio module, wherein the second radio module is configured to communicate along a second wireless communication channel via the second antenna, a communication line coupled to the first radio module and to the first antenna; and a sleeve disposed about the communication line and an external portion of the first cable, wherein the external portion of the first cable is outside the enclosure between the enclosure and the first location, wherein the communication line is configured to be at least partially integrated with the weld cable outside of the enclosure, and wherein the enclosure encompasses components of a welding power unit, a welding device or a gas supply system.
An isolated human cell for use in treating amyotrophic lateral sclerosis,, wherein the human cell secretes brain-derived neurotrophic factor (BDNF) and does not secrete nerve growth factor, wherein a basal secretion of said BDNF is at least five times greater than a basal secretion of a non-differentiated mesenchymal stem cell which expresses CD73, CD90 and CD105 and does not express CD14, CD19, CD34, CD45 and HLA-DR, wherein said basal secretion of non-differentiated MSCs occurs in the absence of stimulants.
A printing module comprising a support and a self-adhesive sheet element having a first face (3-a) coated with adhesive and arranged on said support and a second face (3-b) configured for receiving signs by means of printing, characterized in that said sheet element has preferential breaking lines which delimit a sheet binding element comprising: - a rectangular element; - a plurality of flexible tabs arranged as a comb which integrally extend along a first larger side of the rectangular element; the binding element being separable from said support and being configured to be used with a pack of sheets provided with overlapped through-holes made along one side of each sheet; said tabs being configured for being inserted in respective through-holes with an end of the tabs which protrudes from the holes themselves and is folded and lying on a first face of said pack; said rectangular element being foldable and arranged with at least a portion of second larger side thereof opposite to the first side overlapped to said folded tabs and stably connected with said first face and with said tabs by means of said adhesive for forming a bound booklet. - a rectangular element; - a plurality of flexible tabs arranged as a comb which integrally extend along a first larger side of the rectangular element;
Energy flow control device for controlling a load shift of a plurality of consumers (16, 18, 20, 22, 24), which are connected to a network connection point, depending on temporally variable prices for the electrical energy available at the network connection point, characterized in that the energy flow control device is designed to compare relative efficiencies of the consumers (16, 18, 20, 22, 24) with one another and to control the individual load shifts of the consumers (16, 18, 20, 22, 24) depending on the relative efficiencies, wherein each relative efficiency is defined as an efficiency of the consumer (16, 18, 20, 22, 24) that is normalized to a current efficiency of the consumer (16, 18, 20, 22, 24) with which the consumer (16, 18, 20, 22, 24) would be currently operating with an electrical load that is increased for load shifting purposes, and in that the energy flow control device is designed to read values of the relative efficiencies of the connected consumers (16, 18, 20, 22, 24) from the connected consumers (16, 18, 20, 22, 24) or to determine them from other data provided by the connected consumers (16, 18, 20, 22, 24).
An NMR probe, comprising: a sample tube supporting unit configured to support, during an NMR measurement at a magic angle relative to a static magnetic field, a sample tube used for the NMR measurement; an insertion port through which the sample tube is introduced into or extracted from the sample tube supporting unit; and a direction shifting mechanism through which the sample tube is directed, the direction shifting mechanism being disposed between the sample tube supporting unit and the insertion port in a path of the sample tube, and having a shape which partially includes a form of an arc contained in an approximate circle; wherein the shape of the direction shifting mechanism is designed to cause the sample tube to change an orientation thereof in such a manner that the sample tube is turned toward the insertion port along the arc such that a line segment (SB-SD) on the sample tube is always tangent to the circle, while being maintained in contact with at least two points on an inner wall of the direction shifting mechanism when the sample tube is directed from the sample tube supporting unit to the insertion port and extracted therefrom, wherein the direction shifting mechanism is configured to change the orientation of the sample tube toward the insertion port with a side face of the sample tube being maintained in contact with the arc, and wherein the arc is formed on a face opposite a face that defines said magic angle in the direction shifting mechanism. a sample tube supporting unit configured to support, during an NMR measurement at a magic angle relative to a static magnetic field, a sample tube used for the NMR measurement; an insertion port through which the sample tube is introduced into or extracted from the sample tube supporting unit; and a direction shifting mechanism through which the sample tube is directed, the direction shifting mechanism being disposed between the sample tube supporting unit and the insertion port in a path of the sample tube, and having a shape which partially includes a form of an arc contained in an approximate circle; wherein the shape of the direction shifting mechanism is designed to cause the sample tube to change an orientation thereof in such a manner that the sample tube is turned toward the insertion port along the arc such that a line segment (SB-SD) on the sample tube is always tangent to the circle, while being maintained in contact with at least two points on an inner wall of the direction shifting mechanism when the sample tube is directed from the sample tube supporting unit to the insertion port and extracted therefrom, wherein the direction shifting mechanism is configured to change the orientation of the sample tube toward the insertion port with a side face of the sample tube being maintained in contact with the arc, and wherein the arc is formed on a face opposite a face that defines said magic angle in the direction shifting mechanism.
A controlled release formulation comprising a flowable delivery system comprising an organic solvent, leuprolide as a bioactive agent, and a biocompatible, biodegradable, non-hydrolyzed, acid-terminated poly(DL-lactide-co-glycolide) (PLGH) low-burst copolymer material, the acid-terminated PLGH low-burst copolymer material having a weight average molecular weight of about 10 kilodaltons to about 50 kilodaltons and a polydispersity index of about 1.4-2.0 and from which a removed copolymer fraction having a weight average molecular weight of about 4 kDa to about 10 kDa and a polydispersity index of about 1.4 to 2.5 has been separated, the weight average molecular weight being determined by gel permeation chromatography with reference to polystyrene standards, wherein a content of unreacted lactide and glycolide in the acid-terminated PLGH low-burst copolymer material is less than about 1.0 weight % and 0.1 weight % respectively. the acid-terminated PLGH low-burst copolymer material having a weight average molecular weight of about 10 kilodaltons to about 50 kilodaltons and a polydispersity index of about 1.4-2.0 and from which a removed copolymer fraction having a weight average molecular weight of about 4 kDa to about 10 kDa and a polydispersity index of about 1.4 to 2.5 has been separated, the weight average molecular weight being determined by gel permeation chromatography with reference to polystyrene standards, wherein a content of unreacted lactide and glycolide in the acid-terminated PLGH low-burst copolymer material is less than about 1.0 weight % and 0.1 weight % respectively.
Method for operating a magnetic resonance device having at least one component that has an operating limit in relation to a state parameter, for recording magnetic resonance data using a protocol that comprises at least one magnetic resonance sequence, wherein said protocol is described by protocol parameters and a protocol parameter set is provided or determined which, in relation to a protocol section, allows said protocol section to be repeated as often as desired without exceeding the operating limit, wherein the method has the following steps: - receiving a boost parameter from a user interface, said boost parameter being selected by a user and describing an increased utilisation of the power output of the magnetic resonance device while limiting the repeatability of the protocol section, - at least for the protocol section, determining adaptation parameters in a manner which is at least partially automatic, said adaptation parameters comprising at least some of the protocol parameters, on the basis of the boost parameter in such a way that the desired number of repetitions described by the boost parameter is established while complying with the operating limit, by means of a processor, and - recording magnetic resonance data with the protocol, using the determined adaptation parameters, by means of a controller, wherein the determination of the adaptation parameters is effected using a solution strategy that is selectable by a user, wherein the solution strategy describes an objective selected from the group comprising a reduction in the total time for performing the protocol, increasing the magnetic resonance data quality, and maximising or minimising at least one specific protocol parameter. - receiving a boost parameter from a user interface, said boost parameter being selected by a user and describing an increased utilisation of the power output of the magnetic resonance device while limiting the repeatability of the protocol section, - at least for the protocol section, determining adaptation parameters in a manner which is at least partially automatic, said adaptation parameters comprising at least some of the protocol parameters, on the basis of the boost parameter in such a way that the desired number of repetitions described by the boost parameter is established while complying with the operating limit, by means of a processor, and - recording magnetic resonance data with the protocol, using the determined adaptation parameters, by means of a controller, wherein the determination of the adaptation parameters is effected using a solution strategy that is selectable by a user, wherein the solution strategy describes an objective selected from the group comprising a reduction in the total time for performing the protocol, increasing the magnetic resonance data quality, and maximising or minimising at least one specific protocol parameter.