A self-calibration temperature control device, mainly comprising: a temperature feedback and control unit connected with the controlled heating element to control the work state thereof, a precise temperature measurement unit connected with the controlled heating element to measure the stable temperature thereof, and a temperature calibration unit connected with the precise temperature measurement unit and the temperature feedback and control unit; the temperature calibration unit is used for obtaining temperature from the precise temperature measurement unit, dynamically calibrating temperature drift, and inputting the calibrated result into the temperature control and feedback unit; the temperature feedback and control unit comprises: a negative temperature coefficient thermistor and an analog feedback control circuit that are connected with the controlled heating element to control the final stable temperature of the controlled heating element reaching the setting value through the analog feedback control circuit; the temperature calibration unit comprises: a CPU with a preset temperature range value and a preset resistance adjustment step value, being connected with the precise temperature measurement unit, a data latch circuit with an input end connected with the CPU through a bus, and a digital potentiometer connected with the temperature feedback and control unit, and an output end of the data latch circuit is connected with the digital potentiometer through the bus; the CPU comprises: a judging unit used for judging whether the temperature value measured by the precise temperature measurement unit is within a preset range, a calibration parameter storage module used for storing historical calibration parameter data, and a digital potentiometer connection step setting module, the digital potentiometer connection step setting module is configured to determine an updated calibration parameter value according to the historic calibration parameter data, and further adjust a step value according to a preset resistance value. a temperature feedback and control unit connected with the controlled heating element to control the work state thereof, a precise temperature measurement unit connected with the controlled heating element to measure the stable temperature thereof, and a temperature calibration unit connected with the precise temperature measurement unit and the temperature feedback and control unit; the temperature calibration unit is used for obtaining temperature from the precise temperature measurement unit, dynamically calibrating temperature drift, and inputting the calibrated result into the temperature control and feedback unit; the temperature feedback and control unit comprises: a negative temperature coefficient thermistor and an analog feedback control circuit that are connected with the controlled heating element to control the final stable temperature of the controlled heating element reaching the setting value through the analog feedback control circuit; the temperature calibration unit comprises: a CPU with a preset temperature range value and a preset resistance adjustment step value, being connected with the precise temperature measurement unit, a data latch circuit with an input end connected with the CPU through a bus, and a digital potentiometer connected with the temperature feedback and control unit, and an output end of the data latch circuit is connected with the digital potentiometer through the bus; the CPU comprises: a judging unit used for judging whether the temperature value measured by the precise temperature measurement unit is within a preset range, a calibration parameter storage module used for storing historical calibration parameter data, and a digital potentiometer connection step setting module, the digital potentiometer connection step setting module is configured to determine an updated calibration parameter value according to the historic calibration parameter data, and further adjust a step value according to a preset resistance value.