mhurhangee/ep-ind-claims huggingface dataset:
A method for collecting extracellular vesicles derived from nervous system cells comprising a step of mixing an anti-APLP1 antibody and a sample containing extracellular vesicles to form a complex of the anti-APLP1 antibody and the extracellular vesicle, and a step of collecting the complex of the anti-APLP1 antibody and the extracellular vesicle, wherein the nervous system cells are nerve cells, and the sample is plasma. a step of mixing an anti-APLP1 antibody and a sample containing extracellular vesicles to form a complex of the anti-APLP1 antibody and the extracellular vesicle, and a step of collecting the complex of the anti-APLP1 antibody and the extracellular vesicle, wherein the nervous system cells are nerve cells, and the sample is plasma.
A computer-implemented method, executed on a computing device (12, 22, 24), characterised in that, the method comprising: importing threat data from a plurality of threat data sources (26, 28, 30, 32), thus generating a plurality of raw threat data definitions (34, 36, 38, 40), wherein the plurality of threat data sources includes social network trader sources, wherein importing threat data from a plurality of threat data sources includes defining a list of specific keywords and searching the social network trader sources for the specific keywords, wherein the list of keywords concern one or more of a specific type of attack, a specific company/organization targeted for an attack, and a specific known hacker; processing the plurality of raw threat data definitions (34, 36, 38, 40), thus generating a plurality of processed threat data definitions (44, 46, 48, 50), wherein the plurality of raw threat data definitions include a plurality of data pieces with one or more of an age level and a trust level; processing the plurality of processed threat data definitions to form a master threat data definition; and providing the master threat data definition to one or more client electronic devices (22, 24) to enable the one or more client electronic devices to detect one or more threats. importing threat data from a plurality of threat data sources (26, 28, 30, 32), thus generating a plurality of raw threat data definitions (34, 36, 38, 40), wherein the plurality of threat data sources includes social network trader sources, wherein importing threat data from a plurality of threat data sources includes defining a list of specific keywords and searching the social network trader sources for the specific keywords, wherein the list of keywords concern one or more of a specific type of attack, a specific company/organization targeted for an attack, and a specific known hacker; processing the plurality of raw threat data definitions (34, 36, 38, 40), thus generating a plurality of processed threat data definitions (44, 46, 48, 50), wherein the plurality of raw threat data definitions include a plurality of data pieces with one or more of an age level and a trust level; processing the plurality of processed threat data definitions to form a master threat data definition; and providing the master threat data definition to one or more client electronic devices (22, 24) to enable the one or more client electronic devices to detect one or more threats.
An oral care implement, comprising: an oral care region having an oral collecting member for collecting an oral fluid, the oral collecting member has a thickness which is reduced during oral use; a receiver coupled to the oral collecting member for receiving said oral fluid from said oral collecting member; a fluid pathway in communication with the receiver; and a reservoir in communication with the fluid pathway for retaining said oral fluid; characterized in that the oral collecting member comprises a first layer, a second, soluble layer that erodes away to expose said first layer, and indicia that indicates when the reservoir should be provided for testing. an oral care region having an oral collecting member for collecting an oral fluid, the oral collecting member has a thickness which is reduced during oral use; a receiver coupled to the oral collecting member for receiving said oral fluid from said oral collecting member; a fluid pathway in communication with the receiver; and a reservoir in communication with the fluid pathway for retaining said oral fluid; characterized in that the oral collecting member comprises a first layer, a second, soluble layer that erodes away to expose said first layer, and indicia that indicates when the reservoir should be provided for testing.
A multimer of an organic dye compound, the multimer comprising at least two molecules of the organic dye compound covalently coupled together through a linker, wherein the organic dye compound is selected from the group consisting of Rhodamine 6G, Crystal Violet, and deuterated forms thereof.
A system for using medical imaging data to screen for at least one pancreatic cystic lesion, comprising: a computer hardware arrangement configured to: receive first radiological scan information for the pancreatic region of at least one patient; performing a segmentation operation on the first radiological scan information to identify the pancreas gland and at least one cyst; identify the at least one cyst in the segmented radiological scan information; apply a random forest classifier to a set of quantitative features of the at least one cyst to generate first classification probabilities of the at least one cyst, the features including (i) patient age, (ii) patient gender, (iii) cyst location, (iv) intensity statistics, and (v) shape features; apply a convolutional neural network analyzing imaging features of the at least one cyst to generate second classification probabilities of the at least one cyst; and combining the first classification probabilities and the second classification probabilities into a Bayesian combination to produce probabilities of the at least one cyst being a particular lesion type among a group of lesion types. receive first radiological scan information for the pancreatic region of at least one patient; performing a segmentation operation on the first radiological scan information to identify the pancreas gland and at least one cyst; identify the at least one cyst in the segmented radiological scan information; apply a random forest classifier to a set of quantitative features of the at least one cyst to generate first classification probabilities of the at least one cyst, the features including (i) patient age, (ii) patient gender, (iii) cyst location, (iv) intensity statistics, and (v) shape features; apply a convolutional neural network analyzing imaging features of the at least one cyst to generate second classification probabilities of the at least one cyst; and combining the first classification probabilities and the second classification probabilities into a Bayesian combination to produce probabilities of the at least one cyst being a particular lesion type among a group of lesion types.
A pharmaceutical composition for injection comprising a substantially stable dispersion of solid nanoparticles in an aqueous medium, wherein the solid nanoparticles comprise a microtubule inhibitor and have a mean particle size of less than 220 nm, wherein the composition is prepared by a process comprising: (a) combining an aqueous phase comprising water and an emulsifier and an organic phase comprising the microtubule inhibitor, a water-immiscible organic solvent, optionally a water-miscible organic solvent as an interfacial lubricant and at least one Ostwald ripening inhibitor; (b) forming an oil-in-water emulsion using a high pressure homogenizer; and (c) removing the water-immiscible organic solvent and the water-miscible organic solvent from the oil-in water emulsion under vacuum; thereby forming a substantially stable dispersion of solid nanoparticles comprising the Ostwald ripening inhibitor, the emulsifier and the microtubule inhibitor in the aqueous medium; wherein the Ostwald ripening inhibitor comprises cholesterol and a member selected from the group consisting of cholesteryl stearate, hexadecyl hexadecanoate, glyceryl tristearate, and combinations thereof; wherein the microtubule inhibitor is a taxane;and wherein the emulsifier is albumin. (a) combining an aqueous phase comprising water and an emulsifier and an organic phase comprising the microtubule inhibitor, a water-immiscible organic solvent, optionally a water-miscible organic solvent as an interfacial lubricant and at least one Ostwald ripening inhibitor; (b) forming an oil-in-water emulsion using a high pressure homogenizer; and (c) removing the water-immiscible organic solvent and the water-miscible organic solvent from the oil-in water emulsion under vacuum;
A back knocking device, comprising a stander, a knocking force regulating motor, a knocking force regulating deceleration device, a worm, a main motor, a main motor deceleration device, a small gear, a convex disc, a slide rod, a concave disc, a transitional disc, a large gear, a knocking head, a knocking arm, a turbine, a transmission shaft and a volute spring, wherein the knocking force regulating motor is mounted on the stander, the knocking force regulating motor is connected to one end of the knocking force regulating deceleration device, the other end of the knocking force regulating deceleration device is connected to the worm, the worm is in revolute pair connection with the stander, the worm is engaged with the turbine, the turbine is in revolute pair connection with the transmission shaft, the volute spring has an outer end fixed on the turbine and an inner end fixed on the transmission shaft, the transmission shaft is in revolute pair connection with the stander, the main motor is mounted on the stander, the main motor is connected to one end of the main motor deceleration device, the other end of the main motor deceleration device is connected to the small gear, the small gear is engaged with the large gear, the large gear is in revolute pair connection with the transmission shaft, the convex disc is fixed on the large gear, the transitional disc is fixed on the transmission shaft, the transitional disc is disposed between the convex disc and the concave disc, the slide rod is in sliding pair connection with the transitional disc, the slide rod has one end in higher pair connection with the convex disc and the other end in higher pair connection with the concave disc, the concave disc is in revolute pair connection with the transmission shaft, the concave disc is fixed with the stander, the knocking arm has one end fixed on the transmission shaft and the other end connected to the knocking head.
A method for additive fabrication of an object represented by three-dimensional model data, the method comprising: computing, using first scan data obtained from a scanner after fabricating a first part of the object forming a first surface of the object, first surface data characterizing the first surface of the object; determining second fabrication data characterizing a second set of layers for additive fabrication on the first surface of the object according to the first surface data and the three-dimensional model data for the object, wherein at least one layer of the second set of layers represents a non-planar surface and/or a non-uniform material composition determined from the first surface data; and providing the second fabrication data to control a printer for fabricating the second set of layers. computing, using first scan data obtained from a scanner after fabricating a first part of the object forming a first surface of the object, first surface data characterizing the first surface of the object; determining second fabrication data characterizing a second set of layers for additive fabrication on the first surface of the object according to the first surface data and the three-dimensional model data for the object, wherein at least one layer of the second set of layers represents a non-planar surface and/or a non-uniform material composition determined from the first surface data; and providing the second fabrication data to control a printer for fabricating the second set of layers.
A façade system comprising an insulating board, a plate- or profile-shaped component and a fastening system, wherein the fastening system comprises a fastening element for fastening the insulating board and the plate- or profile-shaped component to an on-site substrate and a connection means, wherein the fastening element comprises a plate-shaped first fastening portion and a shaft-like second fastening portion attached to the latter for receiving the connection means, wherein the shaft-like second fastening portion is passed through the insulating board until the plate-shaped first fastening portion abuts against the insulating board and the connection means is inserted into the shaft-like second fastening portion and is anchored directly or indirectly in the on-site substrate, characterised in that the side of the plate-shaped first fastening portion of the fastening element facing away from the shaft-like second fastening portion comprises pin-shaped, mushroom-shaped, hook-shaped and/or loop-shaped connection elements for the friction-locked and/or form-fit connection to corresponding pin-shaped, mushroom-shaped, hook-shaped and/or loop-shaped connection elements on the plate- or profile-shaped component.
A method for synthesizing a compound represented by formula, comprising step A or step B, Step A: a compound represented by formula and a compound represented by formula are first heated in an organic solvent to react, and the resulting reaction product and a base are heated in the presence of water to continue the reaction to obtain a compound represented by formula; Step B: a compound represented by formula, a compound represented by formula, and a base are heated in an organic solvent to react, and the resulting reaction product is heated in the presence of water to continue the reaction to obtain a compound represented by formula; wherein, R 1 is H or C1-3 alkyl, R 2 is H, -CN, I or Br, R3 is H, I or Br, and R4 is Cl, Br or I. Step A: a compound represented by formula and a compound represented by formula are first heated in an organic solvent to react, and the resulting reaction product and a base are heated in the presence of water to continue the reaction to obtain a compound represented by formula; Step B: a compound represented by formula, a compound represented by formula, and a base are heated in an organic solvent to react, and the resulting reaction product is heated in the presence of water to continue the reaction to obtain a compound represented by formula; wherein, R 1 is H or C1-3 alkyl, R 2 is H, -CN, I or Br, R3 is H, I or Br, and R4 is Cl, Br or I.
Low migration energy-curable compositions comprising epoxy acrylates derived from the reaction of poly(alkylene oxide)-containing glycidyl ethers with acrylic acid, wherein the average degree of alkoxylation of any poly(alkylene oxide) of the glycidyl ether is at least 2 and the number of glycidyl ether groups per molecule is at least 1.
Use of a block copolymer for preparing a coating film, wherein the block copolymer includes a polymer containing a monomer (a) represented by the general formula and a polymer containing at least one monomer (b) selected from the group consisting of monomers represented by the following formulae, and to: In the formulae, and to, R 0 represents an alkyl group having 1 to 3 carbon atoms; R 1 represents a hydrogen atom, or a methyl group; R 2 and R 7 independently represent an alkylene group having 2 or 3 carbon atoms; R 3, R 4, R 5, and R 6 independently represent a hydrogen atom, or an alkyl group having 1 or 2 carbon atoms; X represents a monovalent anion selected from the group consisting of -CO 2 -, -SO 3 -, -OSO 3 -, -OSO 2 -, -OP(=O)(OR 8)O -, -OP(=O)(R 8)O -, -P(=O)(OR 8)O -, and -P(=O)(R 8)O -; R 8 represents an alkyl group having 1 to 3 carbon atoms; and n represents an integer from 1 to 9.
A polyester resin composition for a hot melt adhesive, which comprises an acid component comprising an aromatic dicarboxylic acid and an aliphatic acid; and an alcohol component comprising an aliphatic dihydric alcohol and a polyether-based polyol, wherein the acid component comprises 50 to 85% by mole of the aromatic dicarboxylic acid and 15 to 50% by mole of the aliphatic acid based on the total number of moles of the acid component, and the alcohol component comprises 90 to 98% by mole of the aliphatic dihydric alcohol and 2 to 10% by mole of the polyether-based polyol based on the total number of moles of the alcohol component, wherein the alcohol component comprises 1 to 5% by mole of polyethylene glycol and 1 to 5% by mole of polytetramethylene glycol based on the total number of moles of the alcohol component. wherein the acid component comprises 50 to 85% by mole of the aromatic dicarboxylic acid and 15 to 50% by mole of the aliphatic acid based on the total number of moles of the acid component, and the alcohol component comprises 90 to 98% by mole of the aliphatic dihydric alcohol and 2 to 10% by mole of the polyether-based polyol based on the total number of moles of the alcohol component, wherein the alcohol component comprises 1 to 5% by mole of polyethylene glycol and 1 to 5% by mole of polytetramethylene glycol based on the total number of moles of the alcohol component.
Pellets comprising an active pharmaceutical ingredient belonging to the class II or IV according to Biopharmaceutics Classification System, wherein the pellets further comprise a mixture of microcrystalline cellulose and colloidal silicon dioxide at a weight ratio from 9:1 to 6.5:3.5, wherein the active pharmaceutical ingredient is incorporated in SEDDS comprising a mixture of a medium chain triglyceride and a non-ionic surfactant and wherein the pellets are produced by extrusion/spheronization.
A turbomachine assembly comprising: • a casing comprising: - an inner hub, - an outer shroud extending around and away from the inner hub, - a hollow arm provided with a longitudinal cavity and connecting the inner hub and the outer shroud, • a tube configured to extend inside the longitudinal cavity of the hollow arm of the casing and comprising a central bracket comprising two elastic blades and configured to exert a pressure on the longitudinal cavity wall when the tube is extended within the longitudinal cavity, characterized in that the elastic blades are brazed to the tube or linked to a support configured to be added onto the tube, in that each of the elastic blades has a U shape such that, once it is disposed on the tube, the tube extends into the recess of the U shapes formed by each of the blades, and in that the material(s) of the elastic blades has/have a stress-strain curve comprised between the minimum and maximum stress curves of the following table. Deformation (%) Minimal stress associated (MPa) Maximal stress associated (MPa) 0.5 800 1,250 1 850 1,300 2 900 1,400 5 950 1,470 7.5 1,000 1,500 • a casing comprising: - an inner hub, - an outer shroud extending around and away from the inner hub, - a hollow arm provided with a longitudinal cavity and connecting the inner hub and the outer shroud, - an inner hub, - an outer shroud extending around and away from the inner hub, - a hollow arm provided with a longitudinal cavity and connecting the inner hub and the outer shroud, • a tube configured to extend inside the longitudinal cavity of the hollow arm of the casing and comprising a central bracket comprising two elastic blades and configured to exert a pressure on the longitudinal cavity wall when the tube is extended within the longitudinal cavity,
A polypeptide comprising a binding domain, which is an antibody capable of binding to an epitope of human and Callithrix jacchus, Saguinus oedipus or Saimiri sciureus CD3ε chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs:2, 4, 6, or 8 and comprises at least the amino acid sequence Gln-Asp-Gly-Asn-Glu, wherein the first binding domain comprises a VL region comprising CDR-L1 GSSTGAVTSGNYPN (SEQ ID NO:153), CDR-L2 GTKFLAP (SEQ ID NO:154) and CDR-L3 VLWYSNRWV (SEQ ID NO:155) and a VH region comprising CDR-H 1 KYAMN (SEQ ID NO:174), CDR-H2 RIRSKYNNYATYYADSVKD (SEQ ID NO:175) and CDR-H3 HGNFGNSYISYWAY (SEQ ID NO:176), and wherein the polypeptide further comprises a second binding domain capable of binding to a cell surface antigen which is CD33.
A member for a chassis of a clam shell type electronic apparatus, said member comprising a thermoplastic resin bonded to at least a part of an external-form end face of a laminated sheet, said laminated sheet comprising an intermediate layer arranged between a pair of fiber reinforced resin sheets (40, 41), wherein the thermoplastic resin is extended to a surface of the laminated sheet, characterized by a hole part provided in the surface of the laminated sheet which has been covered with the extended thermoplastic resin and the member for a chassis includes an anchor part formed by putting the thermoplastic resin into the hole part, wherein a female screw part is provided in a part of the thermoplastic resin which has been extended to the surface of the laminated sheet, and wherein a plurality of said female screw parts is arranged side by side, and the anchor part is arranged at a position between two mutually adjacent said female screw parts.
A biocompatible device for use in a method of treating glaucoma in a patient suffering therefrom comprising implanting the biocompatible device into an eye of the patient, the biocompatible device comprising: a) a core comprising: i) between 0.5-1x10 6 ARPE-19 cells that are genetically engineered to secrete ciliary neurotrophic factor (CNTF), and ii) a matrix comprising a plurality of monofilaments twisted into a yarn or woven into a mesh or twisted into a yarn that is in non-woven strands, wherein the cells are distributed thereon; and b) a semi-permeable membrane surrounding the core, wherein the membrane has a nominal molecular weight cut off (MWCO) of about 300 kD that permits the diffusion of the CNTF therethrough; wherein said biocompatible device produces between 0.1 and 20 ng/day of CNTF upon implantation and therapeutically effective amounts of the CNTF for at least 12 months post implantation. a) a core comprising: i) between 0.5-1x10 6 ARPE-19 cells that are genetically engineered to secrete ciliary neurotrophic factor (CNTF), and ii) a matrix comprising a plurality of monofilaments twisted into a yarn or woven into a mesh or twisted into a yarn that is in non-woven strands, wherein the cells are distributed thereon; and i) between 0.5-1x10 6 ARPE-19 cells that are genetically engineered to secrete ciliary neurotrophic factor (CNTF), and ii) a matrix comprising a plurality of monofilaments twisted into a yarn or woven into a mesh or twisted into a yarn that is in non-woven strands, wherein the cells are distributed thereon; and b) a semi-permeable membrane surrounding the core, wherein the membrane has a nominal molecular weight cut off (MWCO) of about 300 kD that permits the diffusion of the CNTF therethrough;