mhurhangee/ep-ind-claims huggingface dataset:
A method for synthesizing xanthohumol, characterised by synthesizing xanthohumol from naringenin in a process comprising steps of: - providing naringenin, - acylating hydroxyl groups at carbons 7 and 4' of a naringenin flavone moiety to obtain an acylation product, - subjecting the acylation product to a reaction of alkylation of a free hydroxyl to an alkoxyl moiety and to a reaction of conversion of the flavone moiety into a chalcone moiety, in the presence of a non-nucleophilic base, in a polar aprotic solvent, to obtain a chalcone compound, - subjecting the chalcone compound to: - a reaction of hydrolysis of its ester groups at carbons 4, 4' and 6 of the chalcone moiety to obtain hydroxyl groups, and next - a reaction of substitution of a prenyl moiety at carbon 5' of the chalcone moiety to obtain xanthohumol. - providing naringenin, - acylating hydroxyl groups at carbons 7 and 4' of a naringenin flavone moiety to obtain an acylation product, - subjecting the acylation product to a reaction of alkylation of a free hydroxyl to an alkoxyl moiety and to a reaction of conversion of the flavone moiety into a chalcone moiety, in the presence of a non-nucleophilic base, in a polar aprotic solvent, to obtain a chalcone compound, - subjecting the chalcone compound to: - a reaction of hydrolysis of its ester groups at carbons 4, 4' and 6 of the chalcone moiety to obtain hydroxyl groups, and next - a reaction of substitution of a prenyl moiety at carbon 5' of the chalcone moiety to obtain xanthohumol. - a reaction of hydrolysis of its ester groups at carbons 4, 4' and 6 of the chalcone moiety to obtain hydroxyl groups, and next - a reaction of substitution of a prenyl moiety at carbon 5' of the chalcone moiety to obtain xanthohumol.
A device for moving sheets of fiber reinforced material having parallel longitudinally oriented fibers embedded in a thermoplastic matrix material, in particular sheets presenting anisotropic stiffness, comprising a conveying path for conveying sheets of fiber reinforced material in a direction substantially along the orientation of the fibers, and a drive element arranged substantially transversely to the conveying path to in use engage a face of a sheet of fiber reinforced material to be conveyed along the path, and arranged to exert friction onto the face in a direction substantially along the orientation of the fibers, characterized in that the device comprises a guide element arranged substantially transversely to the conveying path to in use engage the opposite face of the sheet of fiber reinforced material to be conveyed along the path, the drive element and the guide element being arranged to envelope the conveying path, and in that the drive and guide element are disposed on opposite sides of the conveying path and are interspaced to leave a slot that allows limited free movement of the sheet to be conveyed transverse to its face.
A pouch (100, 200) for securely holding objects during athletic activity, the pouch (100, 200) comprising: an outer envelope that defines an interior chamber that has a first major surface and a second major surface; one or more foam components located within the outer envelope; a resealable opening located on an exterior of the outer envelope providing an opening for an object to be inserted into the interior chamber; and a one-way valve in communication with the interior chamber, wherein once the object is inserted into the pouch (100, 200), the resealable opening is closed and sealed and the one or more foam components are compressed, wherein the compression of the one or more foam components expels the air from the interior chamber of the outer envelope via the one-way valve, and wherein the pouch (100, 200) is fixedly attached to a garment. an outer envelope that defines an interior chamber that has a first major surface and a second major surface; one or more foam components located within the outer envelope; a resealable opening located on an exterior of the outer envelope providing an opening for an object to be inserted into the interior chamber; and a one-way valve in communication with the interior chamber, wherein once the object is inserted into the pouch (100, 200), the resealable opening is closed and sealed and the one or more foam components are compressed, wherein the compression of the one or more foam components expels the air from the interior chamber of the outer envelope via the one-way valve, and wherein the pouch (100, 200) is fixedly attached to a garment.
Claim for electronic control for water heating via plate heat exchanger, where on the primary side of the plate heat exchanger a volume flow valve is switched in the water supply and on the secondary side of the plate heat exchanger at the connection of the water supply a first temperature measuring sensor is located and the volume flow valve and the first temperature sensor are connected with a regulator and furthermore a second temperature measuring sensor is located on the secondary side of the plate heat exchanger in the service water return and the cold water it contains in connection with a regulator, characterised in that, the second temperature measuring sensor is positioned in the front half of an intake chamber of the plate heat exchanger between a first and fifth channel of the plate heat exchanger.
A welding-type system, comprising: a helmet comprising an electronic display configured to display a representation of the power supply and to display one or more indications of one or more parameters of a power supply configured to provide a power output suitable for a welding-type process; characterized in that the helmet further comprises a first inertial measurement unit configured to detect movement of the helmet; and that the welding-type system further comprises a processing system (28, 30) communicatively coupled to the first inertial measurement unit and configured to adjust at least one parameter of the one or more parameters based at least in part on the movement of the helmet, wherein the representation of the power supply includes at least one control element (94, 100) corresponding to at least one parameter of the one or more parameters, wherein movement of the welding helmet corresponds to manipulation of the at least one control element (94, 100) on the representation of the power supply. a helmet comprising an electronic display configured to display a representation of the power supply and to display one or more indications of one or more parameters of a power supply configured to provide a power output suitable for a welding-type process; characterized in that the helmet further comprises a first inertial measurement unit configured to detect movement of the helmet; and that the welding-type system further comprises a processing system (28, 30) communicatively coupled to the first inertial measurement unit and configured to adjust at least one parameter of the one or more parameters based at least in part on the movement of the helmet, wherein the representation of the power supply includes at least one control element (94, 100) corresponding to at least one parameter of the one or more parameters, wherein movement of the welding helmet corresponds to manipulation of the at least one control element (94, 100) on the representation of the power supply.
Motor vehicle structure, including: - an interior with two sides lateral opposite; and - at least one front foot forming a hollow beam extending vertically to the front and to one of the two sides of the carrier, that foot comprising a fastening zone of the lower hinge (17.2) of the front door and a fastening zone of the upper hinge (17.1) of that carrier door; the front foot(s), which also includes a stiffener located on a front face of the hollow beam, between the attachment zones of the lower hinges (17.1, 17.2), in that the stiffener(s) is a U-shaped or U-shaped plate L, and the hollow girder of the front foot(s) includes a wall with an outer longitudinal portion, a transverse portion before forming the front face of the front beam, and a sewn portion connecting the longitudinal portion and transverse portion, the corresponding stiffener plate at least partially embrace the longitudinal portion, the bent portion, and at least partially blend the transverse portion on a given height - an interior with two sides lateral opposite; and - at least one front foot forming a hollow beam extending vertically to the front and to one of the two sides of the carrier, that foot comprising a fastening zone of the lower hinge (17.2) of the front door and a fastening zone of the upper hinge (17.1) of that carrier door;
A method of making a fibrous product comprising: attenuating molten material into fibers at a plurality of fiberizing units associated with a conveyor moving in a machine direction; spraying the fibers with a coolant liquid to cool the fibers, wherein a flow rate of the sprayed coolant liquid is controllable; spraying the cooled fibers with a plurality of binder spray rings; directing the fibers toward a conveyor to form an uncured fibrous pack; measuring a thickness of the uncured pack; controlling the flow rate of the sprayed coolant liquid based on the measured thickness of the uncured pack; and curing the binder in the pack; wherein the step of controlling the flow of coolant liquid includes adjusting the coolant liquid flow to at least one fiberizing unit differently from the flow to at least one other fiberizing unit. attenuating molten material into fibers at a plurality of fiberizing units associated with a conveyor moving in a machine direction; spraying the fibers with a coolant liquid to cool the fibers, wherein a flow rate of the sprayed coolant liquid is controllable; spraying the cooled fibers with a plurality of binder spray rings; directing the fibers toward a conveyor to form an uncured fibrous pack; measuring a thickness of the uncured pack; controlling the flow rate of the sprayed coolant liquid based on the measured thickness of the uncured pack; and curing the binder in the pack; wherein the step of controlling the flow of coolant liquid includes adjusting the coolant liquid flow to at least one fiberizing unit differently from the flow to at least one other fiberizing unit. controlling the flow rate of the sprayed coolant liquid based on the measured thickness of the uncured pack; and curing the binder in the pack; wherein the step of controlling the flow of coolant liquid includes adjusting the coolant liquid flow to at least one fiberizing unit differently from the flow to at least one other fiberizing unit.
A coated metallic tube comprising: an axially elongated tubular sidewall; said tube having a fatigue corrosion cracked outer surface having circumferentially extending cracks projecting radially inwardly partway through the tubular sidewall and a metallic coating on the fatigue corrosion cracked section; wherein the metallic coating is selected from thermally sprayed nickel/chrome/boron and thermally sprayed chrome-free base metal/aluminum//titanium/silicon/boron; and said coating bridges the circumferentially extending cracks and adheres to metal portions of the tube and to corrosion products in the cracks. an axially elongated tubular sidewall; said tube having a fatigue corrosion cracked outer surface having circumferentially extending cracks projecting radially inwardly partway through the tubular sidewall and a metallic coating on the fatigue corrosion cracked section; wherein the metallic coating is selected from thermally sprayed nickel/chrome/boron and thermally sprayed chrome-free base metal/aluminum//titanium/silicon/boron; and said coating bridges the circumferentially extending cracks and adheres to metal portions of the tube and to corrosion products in the cracks.
A kit comprising: (a) a topical composition comprising up to about 5 weight percent of at least one C2 to C5 polycarboxylic acid, and (b) a light delivery device that delivers blue light having a peak wavelength of 400 nm to 460 nm.
A packaged RF power amplifier, comprising: a package comprising an output lead and an input lead; a semiconductor die mounted in the package and comprising: a first drain bond assembly; and an RF power transistor having a drain that is electrically connected to the first drain bond assembly; a first plurality of bondwires extending from the first drain bond assembly to the output lead; a first capacitor arranged in the package and having a first terminal and a second grounded terminal; a second plurality of bondwires electrically connecting the drain to the first terminal of the first capacitor; wherein the semiconductor die comprises an input side that is arranged closer to the input lead than to the output lead and an output side that is arranged closer to the output lead than to the input lead; characterized in that the semiconductor die comprises a second drain bond assembly arranged spaced apart from the first drain bond assembly and electrically connected thereto, wherein the second drain bond assembly is arranged closer to the input side of the semiconductor die than the first drain bond assembly, wherein the second plurality of bondwires extends from the second drain bond assembly to the first terminal of the first capacitor, and wherein the RF power transistor comprises a plurality of drain fingers that extend between the first and second drain bond assemblies. a package comprising an output lead and an input lead; a semiconductor die mounted in the package and comprising: a first drain bond assembly; and an RF power transistor having a drain that is electrically connected to the first drain bond assembly; a first drain bond assembly; and an RF power transistor having a drain that is electrically connected to the first drain bond assembly; a first plurality of bondwires extending from the first drain bond assembly to the output lead; a first capacitor arranged in the package and having a first terminal and a second grounded terminal; a second plurality of bondwires electrically connecting the drain to the first terminal of the first capacitor; wherein the semiconductor die comprises an input side that is arranged closer to the input lead than to the output lead and an output side that is arranged closer to the output lead than to the input lead; characterized in that the semiconductor die comprises a second drain bond assembly arranged spaced apart from the first drain bond assembly and electrically connected thereto, wherein the second drain bond assembly is arranged closer to the input side of the semiconductor die than the first drain bond assembly, wherein the second plurality of bondwires extends from the second drain bond assembly to the first terminal of the first capacitor, and wherein the RF power transistor comprises a plurality of drain fingers that extend between the first and second drain bond assemblies.
A system comprising a home network and a foreign network for a mobile means of a subscriber, said system being adapted to enable shortest connection route for said mobile means when said mobile means has roamed between said home network and said foreign network, characterized in that, said system comprises a voucher registry means comprised in said foreign network, that a serving means comprised in said foreign network is adapted to communicate with, and to receive information regarding a voucher, representing an amount of money, regarding said foreign network, from said voucher registry means, when said mobile means requests connection to Internet, and that said serving means is adapted to route a packet to a gateway means comprised in said foreign network if a voucher, representing enough amount of money, is registered in said voucher registry means, wherein said gateway means is adapted to allocate an IP address for said mobile means and to function as an access point to Internet.
A compound of formula, wherein R 1 is wherein R 7 is selected from the group consisting of OH; (C 1-6 alkyl-2-oxo-1,3-dioxol-4-yl)C 1-6 alkoxy; aminoC 1-6 alkylcarbonyloxyC 1-6 alkoxy; C 1-6 alkoxy; C 1-6 alkoxycarbonyloxyC 1-6 alkoxy; C 1-6 alkylcarbonyloxyC 1-6 alkoxy; C 1-6 alkylsulfonylamino; carboxyC 1-6 alkylaminocarbonylC 1-6 alkylamino and phenylC 1-6 alkoxy; R 8 is C 1-6 alkyl; R 2 is selected from and -N(R 9) 2; wherein R 9 is C 1-6 alkyl; R 10 is selected from the group consisting of C 1-6 alkyl-2-oxo-1,3-dioxol-4-yl; C 1-6 alkoxy(hydroxy)phosphoryloxyC 1-6 alkyl and phosphonooxyC 1-6 alkyl; R 3 is halogen or cyano; R 4 is halogen; R 5 is selected from the group consisting of H; ((aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl; ((aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl; (C 1-6 alkoxy(hydroxy)phosphoryl)C 1-6 alkoxycarbonyl; (C 1 - 6 alkoxy) 2 phosphoryl; aminoC 1-6 alkylcarbonyloxyC 1-6 alkoxycarbonyl; C 1-6 alkylcarbonyloxyC 1-6 alkoxycarbonyl; carboxyC 2-6 alkenylcarbonyloxyC 1-6 alkoxycarbonyl; formyl; phenylC 1-6 alkoxy(hydroxy)phosphoryl; phosphonooxyC 1-6 alkoxycarbonyl and sulfo; R 6 is C 1-6 alkyl; with the proviso that when R 5 is H and R 7 is OH, R 2 is not or -N(R 9) 2; or a pharmaceutically acceptable salt thereof. R 1 is wherein R 7 is selected from the group consisting of OH; (C 1-6 alkyl-2-oxo-1,3-dioxol-4-yl)C 1-6 alkoxy; aminoC 1-6 alkylcarbonyloxyC 1-6 alkoxy; C 1-6 alkoxy; C 1-6 alkoxycarbonyloxyC 1-6 alkoxy; C 1-6 alkylcarbonyloxyC 1-6 alkoxy; C 1-6 alkylsulfonylamino; carboxyC 1-6 alkylaminocarbonylC 1-6 alkylamino and phenylC 1-6 alkoxy; R 8 is C 1-6 alkyl; R 2 is selected from and -N(R 9) 2; wherein R 9 is C 1-6 alkyl; R 10 is selected from the group consisting of C 1-6 alkyl-2-oxo-1,3-dioxol-4-yl; C 1-6 alkoxy(hydroxy)phosphoryloxyC 1-6 alkyl and phosphonooxyC 1-6 alkyl; R 3 is halogen or cyano; R 4 is halogen; R 5 is selected from the group consisting of H; ((aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl; ((aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl)aminoC 1-6 alkylcarbonyl; (C 1-6 alkoxy(hydroxy)phosphoryl)C 1-6 alkoxycarbonyl; (C 1 - 6 alkoxy) 2 phosphoryl; aminoC 1-6 alkylcarbonyloxyC 1-6 alkoxycarbonyl; C 1-6 alkylcarbonyloxyC 1-6 alkoxycarbonyl; carboxyC 2-6 alkenylcarbonyloxyC 1-6 alkoxycarbonyl; formyl; phenylC 1-6 alkoxy(hydroxy)phosphoryl; phosphonooxyC 1-6 alkoxycarbonyl and sulfo; R 6 is C 1-6 alkyl; with the proviso that when R 5 is H and R 7 is OH, R 2 is not or -N(R 9) 2; or a pharmaceutically acceptable salt thereof.
An agricultural mobile silo comprising: - a vehicle chassis which is adapted to travel above the ground, the chassis extending longitudinally forward and rearward, - a storage container which is mounted on the vehicle chassis between the front and the rear of the vehicle chassis and which comprises an upper portion, a lower portion which delimit a single hollow inner cavity, the inner cavity being configured to store agricultural products in the form of seeds, and - a lifting device having a first fixed end secured to the lower portion of the storage container and a second movable end secured to the upper portion of the storage container, the agricultural mobile silo being characterized in that: - the upper portion of the storage container comprises a roof and a telescopic portion which is surmounted by the roof, the telescopic portion having an external periphery which is adapted to be housed in the inner cavity, and - the lifting device is configured to vertically move the upper portion of the storage container between a retracted configuration in which the storage container has a first capacity and a deployed configuration in which the storage container has a second capacity greater than the first capacity, the retracted configuration allowing the entire telescopic portion to be housed in the inner cavity, the deployed configuration allowing all or part of the telescopic portion to extend out of and from the inner cavity. - a vehicle chassis which is adapted to travel above the ground, the chassis extending longitudinally forward and rearward, - a storage container which is mounted on the vehicle chassis between the front and the rear of the vehicle chassis and which comprises an upper portion, a lower portion which delimit a single hollow inner cavity, the inner cavity being configured to store agricultural products in the form of seeds, and - a lifting device having a first fixed end secured to the lower portion of the storage container and a second movable end secured to the upper portion of the storage container, - the upper portion of the storage container comprises a roof and a telescopic portion which is surmounted by the roof, the telescopic portion having an external periphery which is adapted to be housed in the inner cavity, and - the lifting device is configured to vertically move the upper portion of the storage container between a retracted configuration in which the storage container has a first capacity and a deployed configuration in which the storage container has a second capacity greater than the first capacity, the retracted configuration allowing the entire telescopic portion to be housed in the inner cavity, the deployed configuration allowing all or part of the telescopic portion to extend out of and from the inner cavity.
A genetically modified red blood precursor cell characterized by a genomic modification within exon 2 or exon 4 of BCL11A or within BCL11A-XL made following cleavage within the BCL11A gene by a zinc finger nuclease, a TALE nuclease (TALEN) or a CRISPR/Cas system that binds to a target site within any one of SEQ ID NOs: 56, 63, 66, 71, 160, 170, 179, 183, 189, 193, 197, 200, 203, 207, 211 and 213 such that the BCL11A gene is inactivated and gamma globin expression is increased.
A method for the diagnosis of diabetic nephropathy in vitro, comprising the steps of measuring the concentration of a marker for diabetic nephropathy in urine obtained from a subject, wherein the marker is a combination consisting of trimethylglycine and guanidinoacetic acid; obtaining a value relating to a ratio between the measured concentrations of trimethylglycine and guanidinoacetic acid; comparing the obtained value relating to the concentration ratio between of trimethylglycine and guanidinoacetic acid with a threshold; and based on the result of comparison, determining whether or not the subject has diabetic nephropathy; or determining whether the subject undergoing diagnosis has stage I or II diabetic nephropathy or severe diabetic nephropathy.
A form cast piece comprising: - a form cast body formed from a hardened form cast material; - at least one light-guiding element, which is received in the form cast body; - at least one light-guiding element mask, wherein the light-guiding element mask is received inside the form cast body, wherein the at least one light-guiding element is run inside the form cast body by means of the light-guiding element mask, wherein the at least one light-guiding element is run through the at least one light-guiding element mask and wherein a further light-guiding element mask is arranged spaced apart from the at least one light-guiding element mask, characterised in that the at least one light-guiding element is clamped between the at least one light-guiding element mask and the further light-guiding element mask. - a form cast body formed from a hardened form cast material; - at least one light-guiding element, which is received in the form cast body; - at least one light-guiding element mask, wherein the light-guiding element mask is received inside the form cast body, wherein the at least one light-guiding element is run inside the form cast body by means of the light-guiding element mask, wherein the at least one light-guiding element is run through the at least one light-guiding element mask and wherein a further light-guiding element mask is arranged spaced apart from the at least one light-guiding element mask, characterised in that the at least one light-guiding element is clamped between the at least one light-guiding element mask and the further light-guiding element mask.