An imaging system for capturing different images of a sample including a calibration symbol, comprising: a first imaging device for acquiring a first digital image of the sample with a first imaging modality; a second imaging device for acquiring a second digital image of the sample with a second imaging modality, different to the first; a mechanism for translating the sample relative to each of the first and second imaging devices to position the sample, in turn, at an imaging position at each of the first and second imaging devices; and a processor configured to: control the mechanism for translating the sample; receive the first digital image of the sample from the first imaging device; and receive the second digital image of the sample from the second imaging device, said imaging system comprising a pick and place robot for selectively gripping and moving a selected sample to a desired location, under the control of the processor, the sample including a calibration symbol and the processor being further configured to combine the first and second digital images (36,38) of the sample by: receiving a first digital image of the calibration symbol from the first imaging device; receiving a second digital image of the calibration symbol from the second imaging device; comparing the position of the first digital image of the calibration symbol with the position of the second digital image of the same calibration symbol, thereby determining an image offset between the different imaging devices; translating the second digital image of the sample by the determined offset; and superimposing the first digital image of the sample and the translated second digital image of the sample, whereby the first image is in registration with the second image. a first imaging device for acquiring a first digital image of the sample with a first imaging modality; a second imaging device for acquiring a second digital image of the sample with a second imaging modality, different to the first; a mechanism for translating the sample relative to each of the first and second imaging devices to position the sample, in turn, at an imaging position at each of the first and second imaging devices; and a processor configured to: control the mechanism for translating the sample; receive the first digital image of the sample from the first imaging device; and receive the second digital image of the sample from the second imaging device, said imaging system comprising a pick and place robot for selectively gripping and moving a selected sample to a desired location, under the control of the processor, the sample including a calibration symbol and the processor being further configured to combine the first and second digital images (36,38) of the sample by: receiving a first digital image of the calibration symbol from the first imaging device; receiving a second digital image of the calibration symbol from the second imaging device; comparing the position of the first digital image of the calibration symbol with the position of the second digital image of the same calibration symbol, thereby determining an image offset between the different imaging devices; translating the second digital image of the sample by the determined offset; and superimposing the first digital image of the sample and the translated second digital image of the sample, whereby the first image is in registration with the second image. control the mechanism for translating the sample; receive the first digital image of the sample from the first imaging device; and receive the second digital image of the sample from the second imaging device, said imaging system comprising a pick and place robot for selectively gripping and moving a selected sample to a desired location, under the control of the processor, the sample including a calibration symbol and the processor being further configured to combine the first and second digital images (36,38) of the sample by: receiving a first digital image of the calibration symbol from the first imaging device; receiving a second digital image of the calibration symbol from the second imaging device; comparing the position of the first digital image of the calibration symbol with the position of the second digital image of the same calibration symbol, thereby determining an image offset between the different imaging devices; translating the second digital image of the sample by the determined offset; and superimposing the first digital image of the sample and the translated second digital image of the sample, whereby the first image is in registration with the second image.