mhurhangee/ep-ind-claims huggingface dataset:
A method for predicting an improved therapeutic benefit for an individual with a tumor load before initiating an immune therapy with a trifunctional bispecific antibody capable of binding to a T cell via CD3; binding to a tumor-associated target antigen, and binding via its Fc-portion to Fcy-receptor type I, IIa and/or III positive cells and capable of activating immune cells against a tumor carrying said tumor-associated target antigen, said method comprising a. determining the initial relative lymphocyte count in a blood sample provided of said individual before initiating said immune therapy by calculating the percentage of lymphocytes in relation to the absolute number of leukocytes comprising neutrophils, monocytes, eosinophils, basophils and lymphocytes; b. positively correlating said improved therapeutic benefit with increasing initial RLC values of greater than 11%, wherein said tumor-associated target antigen is selected from the group consisting of Her2/neu, CD20, EpCAM, and GD2. a. determining the initial relative lymphocyte count in a blood sample provided of said individual before initiating said immune therapy by calculating the percentage of lymphocytes in relation to the absolute number of leukocytes comprising neutrophils, monocytes, eosinophils, basophils and lymphocytes; b. positively correlating said improved therapeutic benefit with increasing initial RLC values of greater than 11%,
A method for allele assignments where assignments are made on the basis of subjecting a sample including target nucleic acid to a hybridization assay or capture-mediated elongation assay, or both, and where several polymorphic markers, present on alleles in the target nucleic acid are analyzed, the method comprising: determining an assay signal intensity pattern generated by probe-target interactions to generate a reaction pattern by designating as positive those signal intensities exceeding a pre-determined threshold and designating as negative those signal intensities not exceeding the pre-determined threshold, thereby binarizing said assay signal intensity pattern generated by probe-target interactions where each said intensity corresponds to the number of corresponding hybridization or elongation events, as applicable; making allele assignments based on comparing and matching said reaction pattern with a similar reference reaction pattern representing combinations of two or more reference alleles, as listed in a reference collection of alleles for the target nucleic acid under construction; and designating, as new alleles, those having reaction patterns which differ from reference reaction patterns representing combinations of two or more reference alleles by a pre-determined minimal dissimilarity. determining an assay signal intensity pattern generated by probe-target interactions to generate a reaction pattern by designating as positive those signal intensities exceeding a pre-determined threshold and designating as negative those signal intensities not exceeding the pre-determined threshold, thereby binarizing said assay signal intensity pattern generated by probe-target interactions where each said intensity corresponds to the number of corresponding hybridization or elongation events, as applicable; making allele assignments based on comparing and matching said reaction pattern with a similar reference reaction pattern representing combinations of two or more reference alleles, as listed in a reference collection of alleles for the target nucleic acid under construction; and designating, as new alleles, those having reaction patterns which differ from reference reaction patterns representing combinations of two or more reference alleles by a pre-determined minimal dissimilarity.
An apparatus for detecting a periodic timing reference in a received signal, the apparatus comprising: a correlator configured to correlate the received signal with a template to produce a correlated signal indicating the presence of the periodic timing reference in the received signal; an integrator configured to produce an accumulated signal by overlaying one or more delayed versions of the accumulated signal onto the correlated signal, wherein the integrator is configured to delay the accumulated signals by integer multiples L of the period of the periodic timing reference, the integer multiples L being at least two; characterized by a timing detector configured to receive the accumulated signal from the integrator and to indicate timing acquisition or no timing acquisition on the basis of a peak profile of the accumulated signal, wherein the timing detector is configured to separate peaks in the accumulated signal into a plurality of subsets S numbered 0...L-1, wherein the peaks which form part of the S'th subset are at offsets (n*L+S)*P+K, where n and S are integers and K is an unknown in the range [0...P], P being the period of the periodic timing reference, to maintain a count of the number of peaks in each subset whose magnitude exceeds a magnitude threshold, and to indicate timing acquisition only in response to each of the counts exceeding a count threshold. a correlator configured to correlate the received signal with a template to produce a correlated signal indicating the presence of the periodic timing reference in the received signal; an integrator configured to produce an accumulated signal by overlaying one or more delayed versions of the accumulated signal onto the correlated signal, wherein the integrator is configured to delay the accumulated signals by integer multiples L of the period of the periodic timing reference, the integer multiples L being at least two; characterized by a timing detector configured to receive the accumulated signal from the integrator and to indicate timing acquisition or no timing acquisition on the basis of a peak profile of the accumulated signal, wherein the timing detector is configured to separate peaks in the accumulated signal into a plurality of subsets S numbered 0...L-1, wherein the peaks which form part of the S'th subset are at offsets (n*L+S)*P+K, where n and S are integers and K is an unknown in the range [0...P], P being the period of the periodic timing reference, to maintain a count of the number of peaks in each subset whose magnitude exceeds a magnitude threshold, and to indicate timing acquisition only in response to each of the counts exceeding a count threshold.
A composite component, comprising: a metal component having a substantially cylindrical shape or a substantially annular shape; and a ring-shaped bonded magnet disposed on an outer periphery of the metal component, the ring-shaped bonded magnet comprising a thermoplastic resin, magnetic particles, and rubber particles, characterised in that an average particle size of the rubber particles is more than 0.7 μm and less than 1 mm. a metal component having a substantially cylindrical shape or a substantially annular shape; and a ring-shaped bonded magnet disposed on an outer periphery of the metal component, the ring-shaped bonded magnet comprising a thermoplastic resin, magnetic particles, and rubber particles, characterised in that an average particle size of the rubber particles is more than 0.7 μm and less than 1 mm.
Agrochemical composition comprising dodine, and a compatibility agent for dodine wherein the compatibility agent is an alkali metal acetate or earth alkali metal acetate, characterized in that the weight ratio of dodine to that of the compatibility agent in the composition is between 0.5 and 5.0 and wherein the agrochemical composition is in the form of wettable granules or a wettable powder.
A hollow fiber membrane module at least comprising: a tubular body; a cap (6; 7); a hollow fiber membrane; and an end seal portion (8; 8'; 9), wherein at least a liquid contacting portion of the end seal portion is sealed with a cured product of a curable resin composition including an epoxy resin, and wherein the epoxy resin includes a polyglycidyl ether of a polycondensate of an aromatic compound containing a phenolic hydroxyl group and an aromatic compound containing a formyl group and a phenolic hydroxyl group. a tubular body; a cap (6; 7); a hollow fiber membrane; and an end seal portion (8; 8'; 9), wherein at least a liquid contacting portion of the end seal portion is sealed with a cured product of a curable resin composition including an epoxy resin, and wherein the epoxy resin includes a polyglycidyl ether of a polycondensate of an aromatic compound containing a phenolic hydroxyl group and an aromatic compound containing a formyl group and a phenolic hydroxyl group.
A method for detecting an increased risk of developing skin cancer in human subject characterized in that it comprises a) identifying in a biological sample from the subject the genotypes of at least one homozygotic or heterozygotic single nucleotide polymorphisms (SNPs) in exon 11 Grainyhead-like 3 (GRHL3) gene selected from rs41268753 and rs141193530 b) establishing a presence of a genotype leading to an increased risk of developing skin cancer in case of identification at least one of the following genotype: - C->T alteration identified by rs41268753 and/or - C->G alteration identified by rs141193530 a) identifying in a biological sample from the subject the genotypes of at least one homozygotic or heterozygotic single nucleotide polymorphisms (SNPs) in exon 11 Grainyhead-like 3 (GRHL3) gene selected from rs41268753 and rs141193530 b) establishing a presence of a genotype leading to an increased risk of developing skin cancer in case of identification at least one of the following genotype: - C->T alteration identified by rs41268753 and/or - C->G alteration identified by rs141193530 - C->T alteration identified by rs41268753 and/or - C->G alteration identified by rs141193530
Agricultural machine with at least one implement (2, 3) for soil cultivation provided on a machine frame, one of said at least one implement being a roller cutter assembly with two following in sequence rows of roller cutter segments comprising mainly along their periphery arranged and evenly distributed knives, said rows mainly being arranged perpendicular to the travelling direction of the machine, wherein it further comprises said roller cutter segments carrying suspension devices (13, 20) between said roller cutter segments and said machine frame, wherein the knives in said two following in sequence rows of roller cutter segments are fastened to at their lower end journaled in bearings, freely rotating holders each having at the machine frame connected arms, wherein the roller cutter segments are assembled along two beams (6, 7) positioned at the frame, and each roller cutter segment comprises an axle, which bears the holder on the arm, characterised in that said axle is inclined a pre-determined angle (a) between the longitudinal extension of the beams (6,7) and the axis of rotation of the roller cutter segments.
Attachment device to an anchor point comprising: - a wire-like element comprising a first wire-like element end and an opposite second wire-like element end, the first wire-like element end having a first ring with a first pass-through cross-section; - a clamp having a first clamp end and a second clamp end opposite the first clamp end, the first clamp end having a smaller first cross-section than the pass-through cross-section so that the first clamp end can be inserted in the first ring, the second clamp end presenting a second section that is larger than the first cross-section, the first clamp end defining a through hole designed to receive a rope able to support a user, the through hole having a second pass-through cross-section, the second end of the wire-like element being fixed to the clamp via a first attachment point located between the through hole and the second clamp end, the clamp being a rigid part that is curved between the first end and the second end; - a cord having a first cord end fixed to the clamp via a second attachment point and a second cord end having a second ring, the second ring defining a third pass-through cross-section that is smaller than the second pass-through cross-section. - a wire-like element comprising a first wire-like element end and an opposite second wire-like element end, the first wire-like element end having a first ring with a first pass-through cross-section; - a clamp having a first clamp end and a second clamp end opposite the first clamp end, the first clamp end having a smaller first cross-section than the pass-through cross-section so that the first clamp end can be inserted in the first ring, the second clamp end presenting a second section that is larger than the first cross-section, the first clamp end defining a through hole designed to receive a rope able to support a user, the through hole having a second pass-through cross-section, the second end of the wire-like element being fixed to the clamp via a first attachment point located between the through hole and the second clamp end, the clamp being a rigid part that is curved between the first end and the second end; - a cord having a first cord end fixed to the clamp via a second attachment point and a second cord end having a second ring, the second ring defining a third pass-through cross-section that is smaller than the second pass-through cross-section.
A method for determining multiple- input multiple-output, MIMO, resource allocation, comprising: determining a type of a current interval for communicating with a serving base station during a sleep mode; and assigning MIMO resources between the serving base station and at least one neighbor base station based at least in part on the type of the current interval, and characterised in that: the type of the current interval comprises at least one of an available interval or an unavailable interval within the sleep mode. determining a type of a current interval for communicating with a serving base station during a sleep mode; and assigning MIMO resources between the serving base station and at least one neighbor base station based at least in part on the type of the current interval, and characterised in that: the type of the current interval comprises at least one of an available interval or an unavailable interval within the sleep mode. the type of the current interval comprises at least one of an available interval or an unavailable interval within the sleep mode.
Plug-connector part for connection to a mating-plug-connector part, having a housing which has a plug portion for connection with plugging action to the mating-plug-connector part, having a locking element which is arranged movably on the housing and which is configured for locking the mating-plug-connector part to the housing in a locking position and which is movable out of the locking position in order for the locking between the mating-plug-connector part and the housing to be eliminated in an unlocking position, and having a connecting device which connects the locking element to the housing and which has a guide portion, has a guide element which is guided on the guide portion, and has a spring element, wherein the spring element has a latching limb for fixing the guide element with latching action to the guide portion in the locking position and/or the unlocking position, characterized in that the guide element slides along the latching limb during movement of the locking element between the locking position and the unlocking position, and the guide element, during movement of the locking element, thus acts on the latching limb and deflects the latter such that the guide element passes from the unlocking position into the locking position, or conversely from the locking position into the unlocking position, with the latching limb being forced to one side.
A radiator comprising: a plurality of radiation fins; and a radiation fin support base having a heater element mounted to one surface thereof and a plurality of parallel fin grooves, to which the radiation fins are installed, and a projection (11, 12), which exposes from a bottom surface of the fin groove by a predetermined height and is configured to fix the radiation fin, formed to the other surface thereof, wherein the fin groove and the projection (11, 12) are each divided in a plurality of pieces in a longitudinal direction of the fin groove, and each of the divided fin grooves and each of the divided projections (11, 12) have a same length in the longitudinal direction of the fin groove and are paired with each other, characterized in that a top of the projection is pushing one side surface of the radiation fin to push the other side surface of the radiation fin toward a side surface of the fin groove, thereby fixing the radiation fin between the top of the projection (11, 12) and the side surface of the fin groove, and in that the projection (11, 12) is divided into three pieces, and wherein, among the divided projections (11, 12), a height of the projection arranged at the center of the radiation fin support base is higher than a height of the projections arranged at both ends of the radiation fin support base. a plurality of radiation fins; and a radiation fin support base having a heater element mounted to one surface thereof and a plurality of parallel fin grooves, to which the radiation fins are installed, and a projection (11, 12), which exposes from a bottom surface of the fin groove by a predetermined height and is configured to fix the radiation fin, formed to the other surface thereof, wherein the fin groove and the projection (11, 12) are each divided in a plurality of pieces in a longitudinal direction of the fin groove, and each of the divided fin grooves and each of the divided projections (11, 12) have a same length in the longitudinal direction of the fin groove and are paired with each other, characterized in that a top of the projection is pushing one side surface of the radiation fin to push the other side surface of the radiation fin toward a side surface of the fin groove, thereby fixing the radiation fin between the top of the projection (11, 12) and the side surface of the fin groove, and in that the projection (11, 12) is divided into three pieces, and wherein, among the divided projections (11, 12), a height of the projection arranged at the center of the radiation fin support base is higher than a height of the projections arranged at both ends of the radiation fin support base.
A method comprising controlling user-plane data forwarding from a cellular radio access network over a wireless local area network to a terminal, both the cellular radio access network and the wireless local area network providing radio level connectivity for the terminal, wherein in the user-plane data forwarding user-plane data packets according to a cellular data convergence protocol are transported, at least partly, using a Stream Control Transmission protocol over the wireless local area network to the terminal, obtaining performance feedback on the performance of user-plane data packets transport using the Stream Control Transmission protocol, at least, from the wireless local area network, and executing flow control for the user-plane data forwarding from the cellular radio access network over the wireless local area network to the terminal on the basis of the obtained performance feedback. controlling user-plane data forwarding from a cellular radio access network over a wireless local area network to a terminal, both the cellular radio access network and the wireless local area network providing radio level connectivity for the terminal, wherein in the user-plane data forwarding user-plane data packets according to a cellular data convergence protocol are transported, at least partly, using a Stream Control Transmission protocol over the wireless local area network to the terminal, obtaining performance feedback on the performance of user-plane data packets transport using the Stream Control Transmission protocol, at least, from the wireless local area network, and executing flow control for the user-plane data forwarding from the cellular radio access network over the wireless local area network to the terminal on the basis of the obtained performance feedback.
Ventilation device (100, 200) for guiding an airflow for interior ventilation, having an electronic control unit, comprising, in a housing (101, 201): - an interior outlet (110, 210), an exterior outlet (120, 220) and a flow space (130, 230) that extends along a longitudinal axis (131, 231) from the interior outlet (110, 210) to the exterior outlet (120, 220), and - at least one air filter unit (150, 250) mounted swivellably about a swivel axis (155, 255) - an actuator connected to the air filter unit (150, 250) for swivelling movement of the air filter unit (150, 250) about the swivel axis (155, 255), wherein - the swivel axis (155, 255) is arranged perpendicular to the longitudinal axis (131, 231) of the flow space (130, 230), or wherein - the swivel axis (155, 255) is arranged parallel to the longitudinal axis (131, 231) of the flow space outside of the flow space (130, 230), and wherein - at least one bidirectionally operating fan (140, 240) is arranged in the flow space (130, 230) and - the electronic control unit is designed to actuate the respective actuator to a swivelling movement of the air filter unit, on reception of a filter control signal. - an interior outlet (110, 210), an exterior outlet (120, 220) and a flow space (130, 230) that extends along a longitudinal axis (131, 231) from the interior outlet (110, 210) to the exterior outlet (120, 220), and - at least one air filter unit (150, 250) mounted swivellably about a swivel axis (155, 255) - an actuator connected to the air filter unit (150, 250) for swivelling movement of the air filter unit (150, 250) about the swivel axis (155, 255), wherein - the swivel axis (155, 255) is arranged perpendicular to the longitudinal axis (131, 231) of the flow space (130, 230), or wherein - the swivel axis (155, 255) is arranged parallel to the longitudinal axis (131, 231) of the flow space outside of the flow space (130, 230), and wherein - at least one bidirectionally operating fan (140, 240) is arranged in the flow space (130, 230) and - the electronic control unit is designed to actuate the respective actuator to a swivelling movement of the air filter unit, on reception of a filter control signal.
Turbomachine having a valve, wherein the turbomachine comprises an inner inner casing, an outer inner casing and an outer casing, wherein the valve comprises a valve diffuser and a valve housing, wherein the valve housing is connected to the outer casing via a valve flange, wherein the inner inner casing is connected to the valve diffuser via a first angle-ring connection, characterized in that the outer inner casing is connected to the valve diffuser via a second angle-ring connection, and in that a valve ring is shrunk onto the valve diffuser and is designed to receive the second angle-ring connection.
A method for treating nanohydrogels, characterized in that it comprises a dispersion step, in which a nanohydrogel obtained from a polysaccharide functionalized with hydrophobic molecules is dispersed in an aqueous solution to obtain an aqueous dispersion of nanohydrogels, and a sterilization and homogenization step, in which said aqueous dispersion of nanohydrogels is subjected to a temperature of between 70°C and 150°C and a pressure of between 1 and 5 bar; in said sterilization and homogenization step the conditions of temperature and pressure must be such that boiling of the aqueous dispersion of nanohydrogels does not occur.