A ultrasound guide controller configured to control a target biopsy system that includes i) an ultrasound probe operable to project an ultrasound plane intersecting an anatomical region and ii) a target biopsy needle having at least two ultrasound receivers arranged thereon in a known arrangement relative to the target biopsy needle and in which each ultrasound receiver is operable to sense the ultrasound plane as the target biopsy needle is inserted into the anatomical region, the ultrasound guide controller comprising: an ultrasound imaging module, configured based on ultrasound data received from the ultrasound probe, to generate a planar ultrasound image of an anatomical region responsive to ultrasound data representative of an ultrasound plane intersecting the anatomical region; a receiver tracking module, configured based on sense data received from the at least two ultrasound receivers, to track a position of each ultrasound receiver relative to the ultrasound plane responsive to sensing data representative of a sensing of the ultrasound plane as the target biopsy needle is inserted into the anatomical region; and a trajectory prediction module operable in communication with the ultrasound imaging module and the receiver tracking module to predict a biopsy trajectory of the target biopsy needle relative to the ultrasound plane responsive to the tracked positions of the at least two ultrasound receivers relative to the planar ultrasound image of the anatomical region; characterized by said prediction being based on a) a known length of the target biopsy needle prior to firing, b) a known length of the target biopsy needle subsequent to firing, and c) a known attachment point of each ultrasound receiver, said prediction including: determining an orientation of a virtual version of an unfired needle relative to the planar ultrasound image derived from a length of a virtual positioning of a segment of the target biopsy needle between the ultrasound receivers relative to the planar ultrasound image as a function of the tracked positions of the ultrasound receivers; and determining a tip extension of a virtual version of a fired needle previously oriented relative to the planar ultrasound image derived from a length of a virtual positioning of a fired stylet of the target biopsy needle. an ultrasound imaging module, configured based on ultrasound data received from the ultrasound probe, to generate a planar ultrasound image of an anatomical region responsive to ultrasound data representative of an ultrasound plane intersecting the anatomical region; a receiver tracking module, configured based on sense data received from the at least two ultrasound receivers, to track a position of each ultrasound receiver relative to the ultrasound plane responsive to sensing data representative of a sensing of the ultrasound plane as the target biopsy needle is inserted into the anatomical region; and a trajectory prediction module operable in communication with the ultrasound imaging module and the receiver tracking module to predict a biopsy trajectory of the target biopsy needle relative to the ultrasound plane responsive to the tracked positions of the at least two ultrasound receivers relative to the planar ultrasound image of the anatomical region; characterized by said prediction being based on a) a known length of the target biopsy needle prior to firing, b) a known length of the target biopsy needle subsequent to firing, and c) a known attachment point of each ultrasound receiver, said prediction including: determining an orientation of a virtual version of an unfired needle relative to the planar ultrasound image derived from a length of a virtual positioning of a segment of the target biopsy needle between the ultrasound receivers relative to the planar ultrasound image as a function of the tracked positions of the ultrasound receivers; and determining a tip extension of a virtual version of a fired needle previously oriented relative to the planar ultrasound image derived from a length of a virtual positioning of a fired stylet of the target biopsy needle. a) a known length of the target biopsy needle prior to firing, b) a known length of the target biopsy needle subsequent to firing, and c) a known attachment point of each ultrasound receiver, said prediction including: determining an orientation of a virtual version of an unfired needle relative to the planar ultrasound image derived from a length of a virtual positioning of a segment of the target biopsy needle between the ultrasound receivers relative to the planar ultrasound image as a function of the tracked positions of the ultrasound receivers; and determining a tip extension of a virtual version of a fired needle previously oriented relative to the planar ultrasound image derived from a length of a virtual positioning of a fired stylet of the target biopsy needle. determining an orientation of a virtual version of an unfired needle relative to the planar ultrasound image derived from a length of a virtual positioning of a segment of the target biopsy needle between the ultrasound receivers relative to the planar ultrasound image as a function of the tracked positions of the ultrasound receivers; and determining a tip extension of a virtual version of a fired needle previously oriented relative to the planar ultrasound image derived from a length of a virtual positioning of a fired stylet of the target biopsy needle.