Computer-aided method for checking interaction or interference of a flexible body with other bodies (2, 3, 4, 5) situated, in use, close by to the flexible body and arranged, together with the flexible body, on a means, the flexible body presenting, in use, certain points of constraint (A, B, C), the method being characterized in that it comprises the following phases: a) simulating in a virtual environment, by means of a computer, operating conditions of the means on which the flexible body is arranged to determine positions of the points of constraint (A, B, C) of the flexible body in said operating conditions, on the basis of a first three-dimensional mathematical model of the bodies (2, 3, 4, 5) situated, in use, close by to the flexible body; b) positioning the flexible body on a simulation bench designed to physically reproduce the positions of the points of constraint (A, B, C) of the flexible body in a real environment; c) reproducing on the simulation bench the positions of the points of constraint (A, B, C) determined during the simulation in the virtual environment and determining corresponding spatial configurations of the flexible body; d) calculating by means of said computer a second three-dimensional mathematical model of the flexible body on the basis of the determined spatial configurations of the flexible body; e) calculating by means of said computer an integrated three-dimensional mathematical model on the basis of the first and second three-dimensional mathematical models; and f) resimulating in a virtual environment, by means of said computer and on the basis of said integrated three-dimensional mathematical model, operating conditions of the means on which the flexible body is arranged to check any interference of the flexible body with the other bodies (2, 3, 4, 5) situated close by to it in the operating conditions of the means on which it is arranged. a) simulating in a virtual environment, by means of a computer, operating conditions of the means on which the flexible body is arranged to determine positions of the points of constraint (A, B, C) of the flexible body in said operating conditions, on the basis of a first three-dimensional mathematical model of the bodies (2, 3, 4, 5) situated, in use, close by to the flexible body; b) positioning the flexible body on a simulation bench designed to physically reproduce the positions of the points of constraint (A, B, C) of the flexible body in a real environment; c) reproducing on the simulation bench the positions of the points of constraint (A, B, C) determined during the simulation in the virtual environment and determining corresponding spatial configurations of the flexible body; d) calculating by means of said computer a second three-dimensional mathematical model of the flexible body on the basis of the determined spatial configurations of the flexible body; e) calculating by means of said computer an integrated three-dimensional mathematical model on the basis of the first and second three-dimensional mathematical models; and f) resimulating in a virtual environment, by means of said computer and on the basis of said integrated three-dimensional mathematical model, operating conditions of the means on which the flexible body is arranged to check any interference of the flexible body with the other bodies (2, 3, 4, 5) situated close by to it in the operating conditions of the means on which it is arranged.