Apparatus for dissecting biological material from a sample disposed on a planar substrate, comprising a tool interface for releasable attachment of a dissection tool that is connectable to the interface via at least one push fitting (120, 220) and is rotatable about a vertical rotation axis, further comprising an actuator in fixed connection with the interface, wherein the actuator is moveable in vertical direction and is rotatable between a first angular position and a second angular position about the vertical rotation axis; characterised in that the interface further comprises one or more lever arms each pivotably connected to a housing of the interface via a horizontal pivot axis, whereby: • each lever arm is arranged at a radially outer location relative to the at least one push fitting and has first and second ends with respective first and second engagement surfaces (131, 132), the first engagement surface being arranged at a greater radial distance from the vertical axis than the second engagement surface; and • the tool has an upper collar which is dimensioned such that when the tool is attached to the interface, the first engagement surface of each lever arm lies outside of an outer dimension of the upper collar and makes no contact therewith, and is further dimensioned such that the second engagement surface of each lever arm will make contact with an upper surface of the collar when the first end of the lever am is displaced in upward direction; and in that • the apparatus further comprises a receptacle having an opening of sufficient depth to accommodate a main body of the tool, and is configured to detach the tool by lowering the interface towards the opening until the first engagement surface of each lever arm makes contact with a surface that surrounds the opening and is displaced in upward direction, causing each lever arm to pivot such that the corresponding second engagement surface is displaced against the upper surface of the tool and exerts a force on the collar that disengages the at least one push fitting. • each lever arm is arranged at a radially outer location relative to the at least one push fitting and has first and second ends with respective first and second engagement surfaces (131, 132), the first engagement surface being arranged at a greater radial distance from the vertical axis than the second engagement surface; and • the tool has an upper collar which is dimensioned such that when the tool is attached to the interface, the first engagement surface of each lever arm lies outside of an outer dimension of the upper collar and makes no contact therewith, and is further dimensioned such that the second engagement surface of each lever arm will make contact with an upper surface of the collar when the first end of the lever am is displaced in upward direction; and in that • the apparatus further comprises a receptacle having an opening of sufficient depth to accommodate a main body of the tool, and is configured to detach the tool by lowering the interface towards the opening until the first engagement surface of each lever arm makes contact with a surface that surrounds the opening and is displaced in upward direction, causing each lever arm to pivot such that the corresponding second engagement surface is displaced against the upper surface of the tool and exerts a force on the collar that disengages the at least one push fitting.