A computed implemented method comprising: providing at least one previously acquired quantitative image of a subject in a computer readable medium, each of the at least one quantitative images comprising elements, where a value of each element of the image has an absolute value which relates to a property of the subject at a location corresponding to the element, the at least one quantitative image including at least one of quantitative MRI, quantitative PET, quantitative ultrasound or a whole body diffusion weighted imaging MRI; providing an atlas corresponding to the subject, the atlas comprising atlas elements, each of the atlas elements comprising a metric distribution; determining a correspondence map relating elements of the at least one quantitative image to corresponding atlas elements wherein determining the correspondence map comprises segmenting the at least one quantitative image into one or more structure elements and matching the one or more structure elements to the atlas elements defined as structure elements; determining candidate elements by comparing a value of certain elements of the at least one quantitative image with the metric distribution of related atlas elements of the correspondence map; providing at least one previously acquired additional image of the subject, each of the at least one additional images comprising elements, the at least one additional image including at least one non-quantitative image; localizing the candidate elements to corresponding elements of the at least one additional image; classifying the candidate elements into at least one class based on properties of the corresponding elements of the at least one additional image; and determining a disease state of the candidate elements by analyzing the at least one class of the at least one additional image corresponding to the candidate elements. providing at least one previously acquired quantitative image of a subject in a computer readable medium, each of the at least one quantitative images comprising elements, where a value of each element of the image has an absolute value which relates to a property of the subject at a location corresponding to the element, the at least one quantitative image including at least one of quantitative MRI, quantitative PET, quantitative ultrasound or a whole body diffusion weighted imaging MRI; providing an atlas corresponding to the subject, the atlas comprising atlas elements, each of the atlas elements comprising a metric distribution; determining a correspondence map relating elements of the at least one quantitative image to corresponding atlas elements wherein determining the correspondence map comprises segmenting the at least one quantitative image into one or more structure elements and matching the one or more structure elements to the atlas elements defined as structure elements; determining candidate elements by comparing a value of certain elements of the at least one quantitative image with the metric distribution of related atlas elements of the correspondence map; providing at least one previously acquired additional image of the subject, each of the at least one additional images comprising elements, the at least one additional image including at least one non-quantitative image; localizing the candidate elements to corresponding elements of the at least one additional image; classifying the candidate elements into at least one class based on properties of the corresponding elements of the at least one additional image; and determining a disease state of the candidate elements by analyzing the at least one class of the at least one additional image corresponding to the candidate elements.