mhurhangee/ep-ind-claims huggingface dataset:
A method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without organic solvent, characterized in that the method comprises the following steps: 1) cooling an ammonia water system to a certain temperature of 0 to 20 °C; 2) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; 3) after completing the reaction, adding an acid to the system to adjust pH; 4) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and 5) adding a solvent to the dried substance, slurrying, suction filtering and drying to obtain the final product. 1) cooling an ammonia water system to a certain temperature of 0 to 20 °C; 2) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; 3) after completing the reaction, adding an acid to the system to adjust pH; 4) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and 5) adding a solvent to the dried substance, slurrying, suction filtering and drying to obtain the final product.
An expandable implant comprising: - a plurality of links configured to articulate into a generally polygonal shape - the plurality of links (20 comprising a first link, a second link pivotally connected to the first link, and a third link pivotally connected to the second link, - each of the links comprises an upper body having one or more ramped surfaces, a lower body having one or more ramped surfaces, and a middle body positioned between the upper and lower bodies (22, 24) and having one or more ramped surfaces (44, 48), - wherein translation of the middle bodies causes the one or more ramped surfaces (44, 48) of the middle bodies to slide against the one or more ramped surfaces (36, 40) of the upper and lower bodies (22, 24), thereby resulting in expansion of the expandable implant - wherein in a collapsed position, the middle body is positioned towards a perimeter of the implant and as an inward force is provided against each of the middle bodies, the force translates the middle body inwards toward the center of the polygon, resulting in linear expansion of upper and lower surfaces (30, 32) of the upper and lower bodies (22, 24). - a plurality of links configured to articulate into a generally polygonal shape - the plurality of links (20 comprising a first link, a second link pivotally connected to the first link, and a third link pivotally connected to the second link, - each of the links comprises an upper body having one or more ramped surfaces, a lower body having one or more ramped surfaces, and a middle body positioned between the upper and lower bodies (22, 24) and having one or more ramped surfaces (44, 48), - wherein translation of the middle bodies causes the one or more ramped surfaces (44, 48) of the middle bodies to slide against the one or more ramped surfaces (36, 40) of the upper and lower bodies (22, 24), thereby resulting in expansion of the expandable implant - wherein in a collapsed position, the middle body is positioned towards a perimeter of the implant and as an inward force is provided against each of the middle bodies, the force translates the middle body inwards toward the center of the polygon, resulting in linear expansion of upper and lower surfaces (30, 32) of the upper and lower bodies (22, 24).
Display apparatus for a vehicle for displaying at least one symbol, wherein the display apparatus has the following features: a light-transmissive cover layer; a symbol layer (213; 813) having a light-transmissive symbol area for a symbol to be displayed by the display apparatus and having an opaque area surrounding the symbol area, wherein the symbol area is arranged in a manner such that it is spaced apart from the cover layer by a gap (226; 626); and a light-guiding device (228; 528; 828), which is designed to guide light onto a side of the symbol area that faces away from the cover layer, characterized in that the cover layer has, opposite the symbol area, a cutout for forming the gap. a light-transmissive cover layer; a symbol layer (213; 813) having a light-transmissive symbol area for a symbol to be displayed by the display apparatus and having an opaque area surrounding the symbol area, wherein the symbol area is arranged in a manner such that it is spaced apart from the cover layer by a gap (226; 626); and a light-guiding device (228; 528; 828), which is designed to guide light onto a side of the symbol area that faces away from the cover layer, characterized in that the cover layer has, opposite the symbol area, a cutout for forming the gap.
A continuous and uniform conditioning device of ground olive mass by means of power ultrasound, intended to heat an olive mass resulting from milling and circulating through the inside of a duct, the device comprising: - an ultrasound applicator for applying power ultrasound to the olive mass, - a first temperature sensor for determining the temperature of the olive mass at a time immediately prior to applying ultrasound, - a physical and chemical sensor for determining physical and chemical parameters of the olive mass prior to applying ultrasound, - a flow meter for regulating the flow of olive mass circulating through the duct, - a second temperature sensor for determining the temperature of the olive mass at a time immediately after applying ultrasound, and - a controller that acts on: - the ultrasound applicator to modify the frequency and the power of the power ultrasound applied to the olive mass, and - the flow meter for regulating the flow of olive mass circulating through the duct, based on the determinations obtained by the first and the second temperature sensor and the physical and chemical sensor. - an ultrasound applicator for applying power ultrasound to the olive mass, - a first temperature sensor for determining the temperature of the olive mass at a time immediately prior to applying ultrasound, - a physical and chemical sensor for determining physical and chemical parameters of the olive mass prior to applying ultrasound, - a flow meter for regulating the flow of olive mass circulating through the duct, - a second temperature sensor for determining the temperature of the olive mass at a time immediately after applying ultrasound, and - a controller that acts on: - the ultrasound applicator to modify the frequency and the power of the power ultrasound applied to the olive mass, and - the flow meter for regulating the flow of olive mass circulating through the duct, - the ultrasound applicator to modify the frequency and the power of the power ultrasound applied to the olive mass, and - the flow meter for regulating the flow of olive mass circulating through the duct,
An ultrasound catheter designed for disrupting occlusions in blood vessels, the ultrasound catheter comprising: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission member, wherein the proximal housing includes at least one heat dissipation feature (117, 160, 170, 217, 317) for dissipating heat from the proximal portion of the ultrasound transmission member, wherein the heat dissipation feature comprises at least one fluid inlet (117, 217, 317) for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing, the catheter further comprising a guidewire tube extending through at least a portion of the catheter body for allowing passage of a guidewire, wherein a sidewall of the guidewire tube includes a plurality of apertures for allowing fluid introduced into the lumen of the catheter body to pass into and through the guidewire tube. an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission member, wherein the proximal housing includes at least one heat dissipation feature (117, 160, 170, 217, 317) for dissipating heat from the proximal portion of the ultrasound transmission member, wherein the heat dissipation feature comprises at least one fluid inlet (117, 217, 317) for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing, the catheter further comprising a guidewire tube extending through at least a portion of the catheter body for allowing passage of a guidewire, wherein a sidewall of the guidewire tube includes a plurality of apertures for allowing fluid introduced into the lumen of the catheter body to pass into and through the guidewire tube.
A circuit comprising: a positive electrode; a negative electrode spaced apart from the positive electrode; and a polymerase enzyme electrically connected to the positive electrode by a first arm molecule having first and second ends and electrically connected to the negative electrode by a second arm molecule having first and second ends to form a conductive pathway between the positive and negative electrodes through the polymerase enzyme; wherein the first end of the first arm molecule is bonded to the polymerase enzyme and the second end of the first arm molecule is bonded to the positive electrode, wherein the first end of the second arm molecule is bonded to the polymerase enzyme and the second end of the second arm molecule is bonded to the negative electrode, and wherein the first end of each of the first and second arm molecules connect to the polymerase enzyme at two or more points on the polymerase enzyme so as to include a portion of the polymerase enzyme in the conductive pathway. a positive electrode; a negative electrode spaced apart from the positive electrode; and a polymerase enzyme electrically connected to the positive electrode by a first arm molecule having first and second ends and electrically connected to the negative electrode by a second arm molecule having first and second ends to form a conductive pathway between the positive and negative electrodes through the polymerase enzyme; wherein the first end of the first arm molecule is bonded to the polymerase enzyme and the second end of the first arm molecule is bonded to the positive electrode, wherein the first end of the second arm molecule is bonded to the polymerase enzyme and the second end of the second arm molecule is bonded to the negative electrode, and wherein the first end of each of the first and second arm molecules connect to the polymerase enzyme at two or more points on the polymerase enzyme so as to include a portion of the polymerase enzyme in the conductive pathway.
An isolated anti-FcRH5 antibody that binds an isoform c-specific region of the extracellular domain of FcRH5c shown as amino acids 743-850 of SEQ ID NO: 1, wherein the antibody does not significantly bind another Ig-like domain of FcRH5.
A hydraulic steering device hydraulically connecting a steering cylinder to a supply system, wherein the supply system is hydraulically operatively connectible to the steering cylinder via a steering valve to form a main flow connection and the supply system is hydraulically operatively connectible to the steering cylinder via a flow control valve arrangement to form a secondary flow connection circumventing the main flow connection, wherein the flow control valve arrangement is controllable by means of an electrical control apparatus and the flow control valve arrangement comprises individually controllable valve groups (52, 54) which are each connected into the feed line and the return line of the secondary flow connection and the flow control valve arrangement is associated with a release and shutoff valve, characterized in that the release and shutoff valve is connected between the flow control valve arrangement and the steering cylinder and in that the valve group comprises a valve connectible to a feed line port and a valve connectible to a return line port and the valve group comprises a valve connectible to the feed line port and a valve connectible to the return line port and in that, if no steering motion is requested, the release and shutoff valve is in a closed position and the valves (60, 64) are in an open position.
A plant for production of hydrogen peroxide, perfereably of aqueous hydrogen peroxide solutions, by the autoxidation process, the process comprising hydrogenating an anthraquinone in a working solution, oxidizing the hydrogenated anthraquinone with oxygen to form hydrogen peroxide and extracting the hydrogen peroxide from the working solution, the plant comprising at least one skid mounted module selected from the group consisting of: - a skid mounted module comprising at least one hydrogenator to hydrogenate the anthraquinone in the working solution, denoted as skid 1; - a skid mounted module comprising at least one oxidizer to oxidize the hydrogenated anthraquinone with oxygen to form hydrogen peroxide, denoted as skid 2; - optionally a skid mounted module comprising at least one means to compress air, denoted as skid 3, to feed oxygen, in particular oxygen from the air, into an oxidizer of skid 2, and in case of presence of skid 3 a further skid mounted module comprising at least one means to recover the solvent, denoted as skid 4, in particular if oxygen from the air is used to feed oxygen into an oxidizer of skid 2; - a skid mounted module comprising at least one means to extract the hydrogen peroxide from the working solution, denoted as skid 5; - a skid mounted module, denoted as skid 6, comprising at least one means to deliver hydrogen peroxide solution to the point of use and/or optionally to a storage tank optionally with additional means for adjusting the hydrogen peroxide concentration. - a skid mounted module comprising at least one hydrogenator to hydrogenate the anthraquinone in the working solution, denoted as skid 1; - a skid mounted module comprising at least one oxidizer to oxidize the hydrogenated anthraquinone with oxygen to form hydrogen peroxide, denoted as skid 2; - optionally a skid mounted module comprising at least one means to compress air, denoted as skid 3, to feed oxygen, in particular oxygen from the air, into an oxidizer of skid 2, and in case of presence of skid 3 a further skid mounted module comprising at least one means to recover the solvent, denoted as skid 4, in particular if oxygen from the air is used to feed oxygen into an oxidizer of skid 2; - a skid mounted module comprising at least one means to extract the hydrogen peroxide from the working solution, denoted as skid 5; - a skid mounted module, denoted as skid 6, comprising at least one means to deliver hydrogen peroxide solution to the point of use and/or optionally to a storage tank optionally with additional means for adjusting the hydrogen peroxide concentration.
A filling head adapter (150, 170) comprising: an opening that is shaped to enable insertion of a valve of a gas canister that is configured to hold a pressurized or liquefied gas for carbonating a liquid, the valve comprising a body that includes at one end a canister port oriented along a longitudinal axis of the valve, at least one exterior port that opens laterally to the longitudinal axis of the valve, and a gasket configured to fluidically isolate an exterior surface of a plunger of the valve, the plunger configured, when an inward pushing force that overcomes a restoring force is applied to the plunger, to enable fluidic communication between said at least one exterior port and the canister port, characterised in that the filling head adapter comprises: at least one channel that is configured to conduct pressurized gas from a longitudinally oriented filling port of a canister filling system to one or more channels (162, 164) that are in fluidic communication with said at least one exterior port of a valve that is inserted into the opening.
A navigation system for a motor vehicle, comprising - a receiving means for receiving traffic reports, to which a location information object is respectively allocated, - a display means for displaying a digital road map, and - a control means which is coupled to the receiving means and to the display means and is configured such that - the sectors of a digital road map, to which the traffic reports relate, are successively displayed, characterised in that - detailed information objects which are respectively allocated to the traffic reports are displayed on the display means in addition to the sectors of a digital road map which are shown successively, more especially in a preview area and to which the traffic reports relate, a detailed information object comprising location information, information about the time delay associated with the traffic disruption, the road name, the cause of the traffic disruption announced in the traffic report, the nature of the traffic disruption announced in the traffic report and/or the length of the traffic disruption announced in the traffic report, and a location information object comprising location coordinates and/or information about a geographical region and/or information about a section of the road. - a receiving means for receiving traffic reports, to which a location information object is respectively allocated, - a display means for displaying a digital road map, and - a control means which is coupled to the receiving means and to the display means and is configured such that - the sectors of a digital road map, to which the traffic reports relate, are successively displayed, characterised in that - detailed information objects which are respectively allocated to the traffic reports are displayed on the display means in addition to the sectors of a digital road map which are shown successively, more especially in a preview area and to which the traffic reports relate, a detailed information object comprising location information, information about the time delay associated with the traffic disruption, the road name, the cause of the traffic disruption announced in the traffic report, the nature of the traffic disruption announced in the traffic report and/or the length of the traffic disruption announced in the traffic report, and a location information object comprising location coordinates and/or information about a geographical region and/or information about a section of the road.
Machine tool, in particular handheld machine tool, having a working tool and having an optical arrangement (35; 59), which has a window which is located in the vicinity of the workpiece-side working area of the working tool, wherein the optical arrangement has a sensor system, in particular a camera, and the window is formed by a cover, which is located in front of the sensor system on the outlet side, or the front face of the sensor system, in particular the objective of a camera, a protection system is provided for the window, against dirt and/or damage, characterized in that the protection system is in the form of a system which operates with purging air, using purging, dam and/or flow and/or oscillation effects, wherein the purging air is tapped off from a cooling air flow for a drive motor of the machine tool via a fan from which a line connection leads into the area of the window.
An integrated device suitable to act in conjunction with a main transport device that serves a roving frame and with a secondary transport device that serves at least one spinning frame, said integrated device comprising exchange means suitable for picking dirty tubes from the secondary transport device and bobbins from the main transport device, and cleaning means suitable for cleaning of the dirty tubes to obtain empty tubes, said exchange means being suitable for exchanging the bobbins with the empty tubes and releasing the bobbins to the secondary transport device and of the empty tubes to the main transport device, wherein said cleaning of the dirty tubes, said exchanging of the bobbins with the empty tubes, said releasing of the bobbins to the secondary transport device and of the empty tubes to the main transport device are performed locally by said integrated device.
Manufacturing device for producing a double-sided toothed belt, having a hollow cylindrical inner mold, which is closed off by means of a base and a cover and which, on its radial outer side, has teeth oriented parallel to the longitudinal axis of the inner mold, which teeth are in each case spaced apart from one another by a tooth space, having an outer mold, which is arranged with a radial spacing to the inner mold and which is composed of a multiplicity of mold segments which are arranged parallel to the longitudinal axis of the inner mold and adjacent to one another in a circumferential direction of the inner mold and which, at their side pointing toward the inner mold, have in each case at least one tooth and at least one section of a tooth space and/or at least one complete tooth space, having a flexible and hollow cylindrical force transmission element, which is arranged on the radial outer side of the mold segments, having a hollow cylindrical pressure vessel, the hollow cylindrical wall of which surrounds the force transmission element radially at the outside, and having guide elements (16, 16'; 16'') which are fastened or formed in each case on the two axial ends of the respective mold segments and which are arranged in radially movable fashion in respectively associated guides (17; 31), characterized in that the force transmission element is formed as a bellows which is fastened with its two axial ends in pressure-tight fashion to the pressure vessel, in that the force transmission element is arranged in a ring-shaped space which is formed between the hollow cylindrical wall of the pressure vessel and the radial outer side of the mold segments, in that the pressure vessel has at least one pressure medium bore which opens into the ring-shaped space radially outside the force transmission element, in that the mold segments have in each case one axially oriented passage bore through which a heating fluid and a cooling fluid can be conducted, and in that a heating fluid and a cooling fluid can be conducted through the hollow cylindrical inner mold.