A process for isomerization dewaxing of a hydrocarbon feed under superatmospheric hydrogen conditions comprising contacting said hydrocarbon feed with a catalyst system under hydroprocessing conditions, said catalyst system comprising: (a) a large pore crystalline molecular sieve isomerization dewaxing catalyst comprising: a large pore crystalline molecular sieve selected from the group consisting of Zeolite Beta or USY, having a Constraint Index less than 2, an alpha value less than 100 and an ultimate crystal size of less than 1 micron, combined with a Group VIII metal selected from the group consisting of Pt, Pd, Ir, Rh, Ru, Co, Fe, Ni and Os or a combination thereof; and (b) an intermediate pore crystalline molecular sieve isomerization dewaxing catalyst comprising: an intermediate pore crystalline molecular sieve ZSM-23, ZSM-48 or SAPO-11, having a Constraint Index greater than 2, an alpha value less than 100, an ultimate crystal size of less than 1 micron and a unidimensional or a non-intersecting two dimensional pore structure, combined with a Group VIII metal selected from the group consisting of Pt, Pd, Ir, Rh, Ru, Co, Fe, Ni and Os or a combination thereof; wherein said large pore crystalline molecular sieve isomerization dewaxing catalyst and said intermediate pore crystalline molecular sieve isomerization dewaxing catalyst are stacked in a layered configuration or contained in separate reactors; wherein hydrocarbon feed is contacted with said catalyst system in an order starting with said large pore crystalline molecular sieve isomerization dewaxing catalyst followed by said intermediate pore crystalline molecular sieve isomerization dewaxing catalyst; wherein said hydrocarbon feed contains waxy components having a cloud point greater than 0 °C, an ASTM D2887 end boiling point exceeding 275 °C and a pour point greater than 5 °C; wherein the hydroprocessing conditions include a temperature of from 200 °C to 485 °C, a hydrogen partial pressure of from 1375 kPa to 21000 kPa, a hydrogen circulation rate of from 17.8 to 1780 m 3 /m 3 (100 to 10000 scf H2/BBL), and a liquid hourly space velocity (LHSV) of from 0.1 to 20 hr -1 based on the total volume of catalyst; and wherein a dewaxed product having improved fluidity is produced. (a) a large pore crystalline molecular sieve isomerization dewaxing catalyst comprising: a large pore crystalline molecular sieve selected from the group consisting of Zeolite Beta or USY, having a Constraint Index less than 2, an alpha value less than 100 and an ultimate crystal size of less than 1 micron, combined with a Group VIII metal selected from the group consisting of Pt, Pd, Ir, Rh, Ru, Co, Fe, Ni and Os or a combination thereof; and (b) an intermediate pore crystalline molecular sieve isomerization dewaxing catalyst comprising: an intermediate pore crystalline molecular sieve ZSM-23, ZSM-48 or SAPO-11, having a Constraint Index greater than 2, an alpha value less than 100, an ultimate crystal size of less than 1 micron and a unidimensional or a non-intersecting two dimensional pore structure, combined with a Group VIII metal selected from the group consisting of Pt, Pd, Ir, Rh, Ru, Co, Fe, Ni and Os or a combination thereof;