mhurhangee/ep-ind-claims huggingface dataset:
A method of mass spectrometry for determining if a mutated variant of a target protein is present in a sample, comprising: introducing said sample comprising the target protein into a mass spectrometer, wherein the sample is not subjected to liquid chromatography or digestion prior to being introduced into the mass spectrometer; subjecting the sample to fragmentation so as to cause said target protein to fragment to form first fragment ions, wherein said fragmentation is Atmospheric Pressure Electron Capture Dissociation ('Ap-ECD'); Atmospheric Pressure Electron Transfer Dissociation ('Ap-ETD'); Electron Capture Dissociation ("ECD"); or Electron Transfer Dissociation ("ETD"); fragmenting at least some of said first fragment ions to form second fragment ions; mass analysing said second fragment ions to obtain first spectral data; and determining that an ion in the first spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if said target protein was a normal unmutated version of said target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of said target protein. introducing said sample comprising the target protein into a mass spectrometer, wherein the sample is not subjected to liquid chromatography or digestion prior to being introduced into the mass spectrometer; subjecting the sample to fragmentation so as to cause said target protein to fragment to form first fragment ions, wherein said fragmentation is Atmospheric Pressure Electron Capture Dissociation ('Ap-ECD'); Atmospheric Pressure Electron Transfer Dissociation ('Ap-ETD'); Electron Capture Dissociation ("ECD"); or Electron Transfer Dissociation ("ETD"); fragmenting at least some of said first fragment ions to form second fragment ions; mass analysing said second fragment ions to obtain first spectral data; and determining that an ion in the first spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if said target protein was a normal unmutated version of said target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of said target protein.
A method for producing a thin-film solar cell, comprising the steps: a. Applying a CdTe layer onto a substrate, b. Activating the CdTe layer using an activation agent, c. Removing the residual activation agent from the CdTe layer after activation, and d. Performing a temperature treatment under vacuum or in a heating chamber filled with either air, or inert gas, directly after removing the residual activation agent, during which treatment the substrate is exposed to a temperature between 180°C and 380°C for a time between 5 minutes and 60 minutes, wherein the method further comprises the steps: e. Providing the substrate which is a transparent substrate, f. Applying a front contact layer onto the substrate, g. Applying a window layer onto the front contact layer, h. Applying a back contact layer, wherein the steps a) to d) are performed after step g) and before step h). a. Applying a CdTe layer onto a substrate, b. Activating the CdTe layer using an activation agent, c. Removing the residual activation agent from the CdTe layer after activation, and d. Performing a temperature treatment under vacuum or in a heating chamber filled with either air, or inert gas, directly after removing the residual activation agent, during which treatment the substrate is exposed to a temperature between 180°C and 380°C for a time between 5 minutes and 60 minutes, e. Providing the substrate which is a transparent substrate, f. Applying a front contact layer onto the substrate, g. Applying a window layer onto the front contact layer, h. Applying a back contact layer, wherein the steps a) to d) are performed after step g) and before step h).
A modular knee prosthesis system comprising: a distal femoral articulation component having a pair of curved distal condylar articulating surfaces (12, 14), a pair of curved posterior condylar articulating surfaces (16, 18), a distal bone-facing surface (26, 28) and a posterior bone-facing surface (30, 32), and an augment sized and shaped to be received on one of the bone-facing surfaces of the distal femoral articulation component, the augment including a first surface, a second surface spaced from and generally opposite to the first surface, and side surfaces (68, 70) extending between and connecting the first surface and the second surface, a body between the first and second surface, at least one of the side surfaces having an opening into a bore extending from the side surface through the body and through another surface of the augment, characterised in that the system includes a first connector for securing the augment to the distal femoral articulation component, the distal femoral articulation component having an opening to receive the connector to selectively mount the augment to the distal femoral articulation component. a distal femoral articulation component having a pair of curved distal condylar articulating surfaces (12, 14), a pair of curved posterior condylar articulating surfaces (16, 18), a distal bone-facing surface (26, 28) and a posterior bone-facing surface (30, 32), and an augment sized and shaped to be received on one of the bone-facing surfaces of the distal femoral articulation component, the augment including a first surface, a second surface spaced from and generally opposite to the first surface, and side surfaces (68, 70) extending between and connecting the first surface and the second surface, a body between the first and second surface, at least one of the side surfaces having an opening into a bore extending from the side surface through the body and through another surface of the augment, characterised in that the system includes a first connector for securing the augment to the distal femoral articulation component, the distal femoral articulation component having an opening to receive the connector to selectively mount the augment to the distal femoral articulation component.
A method of manufacturing a seal assembly for a vehicle with said method utilizing a molding apparatus defining a mold cavity, said method comprising the steps of: extruding a first strip of material to form a first body having opposing first body ends (122, 124); extruding a second strip of material to form a second body having opposing second body ends (136, 138); positioning one of the first body ends (122, 124) and one of the second body ends (136, 138) into the mold cavity of the molding apparatus with the first body end positioned adjacent the second body end; injecting an elastomeric material into the mold cavity to form a locator device having a foot portion and a tab portion extending from the foot portion with the tab portion defining a first reference point and with the foot portion of the locator device positioned adjacent the first body end; and injecting a thermoplastic elastomeric material into the mold cavity to form a corner mold covering the first body end, the second body end, and the foot portion of the locator device with the corner mold defining a second reference point, and the corner mold bonding the first body end, the second body end, and the locator device together and to fix the foot portion of the locator device to the first body end at a locator position such that a predetermined distance between the first and second reference points (R1, R2) is maintained during the injecting of the thermoplastic elastomeric material. extruding a first strip of material to form a first body having opposing first body ends (122, 124); extruding a second strip of material to form a second body having opposing second body ends (136, 138); positioning one of the first body ends (122, 124) and one of the second body ends (136, 138) into the mold cavity of the molding apparatus with the first body end positioned adjacent the second body end; injecting an elastomeric material into the mold cavity to form a locator device having a foot portion and a tab portion extending from the foot portion with the tab portion defining a first reference point and with the foot portion of the locator device positioned adjacent the first body end; and injecting a thermoplastic elastomeric material into the mold cavity to form a corner mold covering the first body end, the second body end, and the foot portion of the locator device with the corner mold defining a second reference point, and the corner mold bonding the first body end, the second body end, and the locator device together and to fix the foot portion of the locator device to the first body end at a locator position such that a predetermined distance between the first and second reference points (R1, R2) is maintained during the injecting of the thermoplastic elastomeric material.
A public safety network, PSN, node configured to share one or more frequency carriers of a PSN with a commercial network, CN, the PSN node comprising a processing circuit and a communication interface connected to the processing circuit, the processing circuit configured to: - obtain information indicating a level of warning in the PSN, wherein the information comprises at least one of a type of a warning situation, a severity level of the warning, a duration of the warning, and an area or location affected by the warning; - determine whether a PSN carrier is available for use in the CN based on the obtained information, and when it is determined that the PSN carrier is available for use in the CN, - release the PSN carrier from operation in at least one node of the PSN, and - send information via the communication interface to a CN node indicating that the PSN carrier is available for use in the CN. - obtain information indicating a level of warning in the PSN, wherein the information comprises at least one of a type of a warning situation, a severity level of the warning, a duration of the warning, and an area or location affected by the warning; - determine whether a PSN carrier is available for use in the CN based on the obtained information, and when it is determined that the PSN carrier is available for use in the CN, - release the PSN carrier from operation in at least one node of the PSN, and - send information via the communication interface to a CN node indicating that the PSN carrier is available for use in the CN.
A humanized antibody that specifically binds and antagonizes GDF-8, comprising: an antibody variable heavy region having the amino acid sequence of SEQ ID NO:7 or which differs by no more than 2 amino acid residues from the amino acid sequence of SEQ ID NO:7, and an antibody variable light region having the amino acid sequence of SEQ ID NO:9 or which differs by no more than 2 amino acid residues from the amino acid sequence of SEQ ID NO:9; wherein the first CDR from a VH region has the amino acid sequence of SEQ ID NO:10, the second CDR from a VH region has the amino acid sequence of SEQ ID NO:11, the third CDR from a VH region has the amino acid sequence of SEQ ID NO:12, the first CDR from a VL region has the amino acid sequence of SEQ ID NO:13, the second CDR from a VL region has the amino acid sequence of SEQ ID NO:14, the third CDR from a VL region has the amino acid sequence of SEQ ID NO:15, or wherein the first CDR from a VH region has the amino acid sequence of SEQ ID NO:20, the second CDR from a VH region has the amino acid sequence of SEQ ID NO:21, the third CDR from a VH region has the amino acid sequence of SEQ ID NO:22, the first CDR from a VL region has the amino acid sequence of SEQ ID NO:23, the second CDR from a VL region has the amino acid sequence of SEQ ID NO:24, the third CDR from a VL region has the amino acid sequence of SEQ ID NO:25. an antibody variable heavy region having the amino acid sequence of SEQ ID NO:7 or which differs by no more than 2 amino acid residues from the amino acid sequence of SEQ ID NO:7, and an antibody variable light region having the amino acid sequence of SEQ ID NO:9 or which differs by no more than 2 amino acid residues from the amino acid sequence of SEQ ID NO:9; wherein the first CDR from a VH region has the amino acid sequence of SEQ ID NO:10, the second CDR from a VH region has the amino acid sequence of SEQ ID NO:11, the third CDR from a VH region has the amino acid sequence of SEQ ID NO:12, the first CDR from a VL region has the amino acid sequence of SEQ ID NO:13, the second CDR from a VL region has the amino acid sequence of SEQ ID NO:14, the third CDR from a VL region has the amino acid sequence of SEQ ID NO:15, or wherein the first CDR from a VH region has the amino acid sequence of SEQ ID NO:20, the second CDR from a VH region has the amino acid sequence of SEQ ID NO:21, the third CDR from a VH region has the amino acid sequence of SEQ ID NO:22, the first CDR from a VL region has the amino acid sequence of SEQ ID NO:23, the second CDR from a VL region has the amino acid sequence of SEQ ID NO:24, the third CDR from a VL region has the amino acid sequence of SEQ ID NO:25.
Cassette filter with a multiplicity of filter media packs, wherein in each case two filter media packs are arranged in a v-shaped manner and with a frame for receiving the filter media packs, wherein the frame possesses an inflow-side head plate, an outflow-side foot plate and two side plates, wherein the side plates have a flow-optimized shaping (60, 64), wherein the side plates are formed by trapezoidal lateral surfaces arranged in rows, characterized in that, in at least one of the cavities between limbs of trapezoidal lateral surfaces which adjoin one another, strut-shaped air guiding elements are arranged in at least two parallel planes parallel to the head plate and foot plate.
Adjustment installation for a track conditioning unit having: - at least one measuring unit - for determining a relative transverse offset of a rail traveled by a rail vehicle in relation to an effective range of a track conditioning unit of the rail vehicle; or - for determining a relative position of a bogie and of the car body of the rail vehicle; - a detection unit for determining an actuation command for an actuation unit as a function of - the determined transverse offset between the effective range of the track conditioning unit and the rail; or - alternatively as a function of the relative position of the bogie in relation to the car body of the rail vehicle; - the actuation unit for actuating an actuator unit of the track conditioning unit using an adjustment command based on the actuation command; - the actuator unit for adjusting an effective range of the track conditioning unit based on the adjustment command; characterized in that the actuator unit is specified for displacing the effective range of the adjustment installation for a track conditioning unit in that one of a plurality of transversely offset exit openings (25a, 25b) for auxiliary media is opened, the effective range of said exit opening being the most suitable for the determined transverse offset. - at least one measuring unit - for determining a relative transverse offset of a rail traveled by a rail vehicle in relation to an effective range of a track conditioning unit of the rail vehicle; or - for determining a relative position of a bogie and of the car body of the rail vehicle; - for determining a relative transverse offset of a rail traveled by a rail vehicle in relation to an effective range of a track conditioning unit of the rail vehicle; or - for determining a relative position of a bogie and of the car body of the rail vehicle; - a detection unit for determining an actuation command for an actuation unit as a function of - the determined transverse offset between the effective range of the track conditioning unit and the rail; or - alternatively as a function of the relative position of the bogie in relation to the car body of the rail vehicle; - the determined transverse offset between the effective range of the track conditioning unit and the rail; or - alternatively as a function of the relative position of the bogie in relation to the car body of the rail vehicle; - the actuation unit for actuating an actuator unit of the track conditioning unit using an adjustment command based on the actuation command; - the actuator unit for adjusting an effective range of the track conditioning unit based on the adjustment command;
Method for manufacturing a mineral foam comprising the following steps: (i) separately preparing an aqueous foam and a cement slurry, the cement slurry comprising water W, a cement C, a water-reducing agent, a water-soluble calcium salt, a water-soluble silicate salt, with the calcium / silicon molar ratio being 0.7 to 1.7 and the W/C weight ratio being 0.25 to 0.40, and being understood that the concentration in calcium ions is 0.03 to 0.97%, expressed as a weight percent relative to the weight of cement C and that the concentration in silicate ions is comprised between 0.04 and 1.67% expressed as a weight percent relative to the weight of cement C; (ii) putting the cement slurry obtained in contact with the aqueous foam to obtain a foamed cement slurry; and (iii) shaping the foamed cement slurry obtained in step (ii) and allowing setting to occur. (i) separately preparing an aqueous foam and a cement slurry, the cement slurry comprising water W, a cement C, a water-reducing agent, a water-soluble calcium salt, a water-soluble silicate salt, with the calcium / silicon molar ratio being 0.7 to 1.7 and the W/C weight ratio being 0.25 to 0.40, and being understood that the concentration in calcium ions is 0.03 to 0.97%, expressed as a weight percent relative to the weight of cement C and that the concentration in silicate ions is comprised between 0.04 and 1.67% expressed as a weight percent relative to the weight of cement C; (ii) putting the cement slurry obtained in contact with the aqueous foam to obtain a foamed cement slurry; and (iii) shaping the foamed cement slurry obtained in step (ii) and allowing setting to occur.
A filling adapter for a container to be filled with media, particularly for the initial filling of containers with operating fluids on assembly lines for manufacturing motor vehicles, wherein the filling adapter is equipped with a hose pack, electric, pneumatic, and hydraulic lines; wherein the filling adapter comprises a barrel and a ball piece and is operatively connected to two media lines in a hose pack; wherein redistribution of the media takes place in the adapter head in which a filling valve and a vacuum valve are disposed, each of which being connected to the barrel, characterized in that a ventilation line is branched off via a check valve from a vacuum line in the hose pack and connected to the ball piece.
A positive electrode for a lithium secondary battery comprising a positive electrode current collector and a positive electrode active material layer coated and formed on at least one surface of the positive electrode current collector, wherein the positive electrode current collector includes a portion that protrudes from the positive electrode current collector and that is not coated by the positive electrode active material layer, and wherein a high-capacity irreversible material composed of lithium oxide is coated on the protruding portion. wherein the positive electrode current collector includes a portion that protrudes from the positive electrode current collector and that is not coated by the positive electrode active material layer, and wherein a high-capacity irreversible material composed of lithium oxide is coated on the protruding portion.
A light comprising: a primary lightpipe; and, a light source; wherein the primary lightpipe comprises: a lightpipe inlet side constructed and arranged to receive light from the light source and to allow it to enter the primary lightpipe; a back side being provided with a serrated structure, wherein the serrated structure has a first and a second surface and the first surface is provided with a reflecting surface to reflect light from the light source; and a front side constructed and arranged to internally reflect the light received from the light source to the back side of the primary lightpipe and to transmit light received from the reflecting surface, characterized in that the second surface is provided with a light absorbing surface, and the second surface is substantially perpendicular to the back side. a primary lightpipe; and, a light source; a lightpipe inlet side constructed and arranged to receive light from the light source and to allow it to enter the primary lightpipe; a back side being provided with a serrated structure, wherein the serrated structure has a first and a second surface and the first surface is provided with a reflecting surface to reflect light from the light source; and a front side constructed and arranged to internally reflect the light received from the light source to the back side of the primary lightpipe and to transmit light received from the reflecting surface, characterized in that the second surface is provided with a light absorbing surface, and the second surface is substantially perpendicular to the back side.
Method for detuning a rotor-blade cascade, comprising a multiplicity of rotor blades, of a turbomachine, having the steps: a) establishing for each of the rotor blades of the rotor-blade cascade at least one setpoint natural frequency ν F,S which the rotor blade has for at least one predetermined oscillation mode during normal operation of the turbomachine under the effect of centrifugal force, such that the oscillation load of the rotor-blade cascade under the centrifugal force lies below a tolerance limit; b) compiling a value table ν F (m, r S) with selected discrete mass values m and radial center-of-mass positions r S, which result from variations (6 to 9) of the nominal geometry of the rotor blade, and determining the respective natural frequency ν F of the predetermined oscillation mode under the centrifugal force for each selected value pair m and r S; c) measuring the mass m I and the radial center-of-mass position r S,I of one of the rotor blades; d) determining actual natural frequency ν F,I of the rotor blade under the centrifugal force by interpolation of the measured mass m I and the measured radial center-of-mass position r S,I in the value table ν F (m, r S); e) in the event that ν F,I lies outside a tolerance around ν F,S, selecting from the value table ν F (m, r S) a value pair m S and r S,S such that ν F,I at least approximates ν F,S, and removing material of the rotor blade in such a way that m I and r S,I correspond to the value pair m S and r S,S; f) repeating steps c) to e) until ν F,I lies within the tolerance around ν F,S. a) establishing for each of the rotor blades of the rotor-blade cascade at least one setpoint natural frequency ν F,S which the rotor blade has for at least one predetermined oscillation mode during normal operation of the turbomachine under the effect of centrifugal force, such that the oscillation load of the rotor-blade cascade under the centrifugal force lies below a tolerance limit; b) compiling a value table ν F (m, r S) with selected discrete mass values m and radial center-of-mass positions r S, which result from variations (6 to 9) of the nominal geometry of the rotor blade, and determining the respective natural frequency ν F of the predetermined oscillation mode under the centrifugal force for each selected value pair m and r S; c) measuring the mass m I and the radial center-of-mass position r S,I of one of the rotor blades; d) determining actual natural frequency ν F,I of the rotor blade under the centrifugal force by interpolation of the measured mass m I and the measured radial center-of-mass position r S,I in the value table ν F (m, r S); e) in the event that ν F,I lies outside a tolerance around ν F,S, selecting from the value table ν F (m, r S) a value pair m S and r S,S such that ν F,I at least approximates ν F,S, and removing material of the rotor blade in such a way that m I and r S,I correspond to the value pair m S and r S,S; f) repeating steps c) to e) until ν F,I lies within the tolerance around ν F,S.