mhurhangee/ep-ind-claims huggingface dataset:
An analytical method for determining a cerebral Aβ accumulation state, the method comprising: a measurement step of subjecting a living body-derived sample derived from a test subject to detection of a marker containing: APP672-713 (Aβ1-42) (SEQ ID NO.: 6) and APP672-711 (Aβ1-40) (SEQ ID NO.: 4), to obtain measurement levels of: APP672-713 (Aβ1-42) and APP672-711 (Aβ1-40) in the living body-derived sample; a calculation step of calculating a ratio of APP672-711 (Aβ1-40) level to APP672-713 (Aβ1-42) level: APP672-711 (Aβ1-40)/APP672-713 (Aβ1-42); and an evaluation step of determining that an amount of cerebral Aβ accumulation of the test subject is larger than an amount of cerebral Aβ accumulation of a person having normal cognitive function who is negative for cerebral Aβ accumulation (NC-), when the ratio of the test subject is higher than a standard level which is a ratio of the person having normal cognitive function who is negative for cerebral Aβ accumulation (NC-). APP672-713 (Aβ1-42) (SEQ ID NO.: 6) and APP672-711 (Aβ1-40) (SEQ ID NO.: 4), a calculation step of calculating a ratio of APP672-711 (Aβ1-40) level to APP672-713 (Aβ1-42) level: APP672-711 (Aβ1-40)/APP672-713 (Aβ1-42); and an evaluation step of determining that an amount of cerebral Aβ accumulation of the test subject is larger than an amount of cerebral Aβ accumulation of a person having normal cognitive function who is negative for cerebral Aβ accumulation (NC-), when the ratio of the test subject is higher than a standard level which is a ratio of the person having normal cognitive function who is negative for cerebral Aβ accumulation (NC-).
Use of at least one compound of the following formula: In which, • n = 0 or 1, • Ra represents -COOH • Rb represents an alkyl group having 1 to 3 carbon atoms, preferably a -CH 3 group, • Z represents -CHOH-CH 2 -, -CH 2 -CH 2 -, -CO-NH-CH 2 -, • wherein said compound may be in the form of salts or, when at least one asymmetric carbon atom is present, in the form of isolated isomers or as a racemic mixture, • wherein said compound differs from vanillyllactic acid and homovanillic acid, as a physiological marker for carrying out a method for the in vitro or ex vivo diagnosis of psychiatric disorders belonging to the group consisting of autism, development retardation and autism linked to intestinal dysbioses. • n = 0 or 1, • Ra represents -COOH • Rb represents an alkyl group having 1 to 3 carbon atoms, preferably a -CH 3 group, • Z represents -CHOH-CH 2 -, -CH 2 -CH 2 -, -CO-NH-CH 2 -, • wherein said compound may be in the form of salts or, when at least one asymmetric carbon atom is present, in the form of isolated isomers or as a racemic mixture, • wherein said compound differs from vanillyllactic acid and homovanillic acid,
An endoscopic apparatus, characterized by comprising: an endoscope having an inserting section to be inserted in body cavity with a distal end including an observation section to observe a subject and a suction opening; a sucking device in communicated with the suction opening; and a hood member which is attached to the distal end of the inserting section and which has a holding section to attract and hold a medical capsule when the sucking device is actuated to suck the inside of the hood member via the suction opening to make the inside of the hood member vacuum, wherein the hood member is generally cylindrical, has a rear end, which is fit onto an outer circumferential surface of the inserting section of the inserting section of the endoscope, and a distal end comprising the holding section, the hood member has a middle portion, a distal end portion wherein the middle portion is transparent or semitransparent, characterized in that the distal end portion is formed of a material which is more flexible than that for the middle portion and elastically deforms along the medical capsule. an endoscope having an inserting section to be inserted in body cavity with a distal end including an observation section to observe a subject and a suction opening; a sucking device in communicated with the suction opening; and a hood member which is attached to the distal end of the inserting section and which
A minimally invasive articulate surgical endoscope coupled to a surgical robotic system having a plurality of arms, a master input device having at least six degrees of freedom, and a slave which articulates the surgical endoscope in response to repositioning of the master input device, the endoscope comprising: an elongate shaft having a working end, a proximal end, and a shaft axis between the working end and the proximal end; a flexible wrist having a distal end and a proximal end, the proximal end of the wrist connected to the working end of the elongate shaft; an endoscopic camera lens installed at the distal end of the wrist, the camera lens for acquiring an image of an object; and a plurality of actuation links connecting the wrist to the proximal end of the elongate shaft such that the links are actuatable to provide the wrist with at least one degree of freedom; wherein a reference frame used for controlling the at least one degree of freedom motion is attached to the flexible wrist for wrist motion associated with the at least one degree of freedom; and wherein a reference frame used for controlling other degrees of freedom associated with the endoscope is attached to the object. an elongate shaft having a working end, a proximal end, and a shaft axis between the working end and the proximal end; a flexible wrist having a distal end and a proximal end, the proximal end of the wrist connected to the working end of the elongate shaft; an endoscopic camera lens installed at the distal end of the wrist, the camera lens for acquiring an image of an object; and a plurality of actuation links connecting the wrist to the proximal end of the elongate shaft such that the links are actuatable to provide the wrist with at least one degree of freedom; wherein a reference frame used for controlling the at least one degree of freedom motion is attached to the flexible wrist for wrist motion associated with the at least one degree of freedom; and wherein a reference frame used for controlling other degrees of freedom associated with the endoscope is attached to the object.
A water-absorbent resin, wherein the water-absorbent resin is obtained by reverse phase suspension polymerization on a water-soluble ethylenically unsaturated monomer in the presence of an internal-crosslinking agent and in the presence of an azo based compound and a peroxide; and performing post-crosslinking thereon with a post-crosslinking agent, and the water-absorbent resin satisfies the requirements below: yellow index is 5.0 or less; gel strength is 1800 Pa or less; and a water-absorption capacity of physiological saline under a load of 4.14 kPa is 16 ml/g or more; and wherein the water-soluble ethylenically unsaturated monomer comprises acrylic acid or salts thereof; and wherein the post-crosslinking agent is at least one selected from the group consisting of (poly)ethylene glycol diglycidyl ether, (poly)glycerin diglycidyl ether, (poly)glycerin triglycidyl ether, trimethylolpropane triglycidyl ether, (poly)propylene glycol polyglycidyl ether, and (poly)glycerol polyglycidyl ether. yellow index is 5.0 or less; gel strength is 1800 Pa or less; and a water-absorption capacity of physiological saline under a load of 4.14 kPa is 16 ml/g or more;
A method for transmitting network resource information data, comprising, step 1, transmitting, by a transport layer function entity, the network resource information data including network topology and variation status information, network link bandwidth utilization status information to a transport control layer function entity; and step 2, the transport control layer function entity creating network resource status data according to the collected network resource information data, and performing resource admission control and path selection to a session according to the network resource status data, wherein, the network resource information data further comprise a traffic class and service mode information of the traffic class, resource and utilization status information of the traffic class; characterised by: when a new service session request arrives, selecting a path having enough remaining bandwidth by the transport control layer function entity to serve the service traffic, wherein the selected path has a corresponding service traffic class and a corresponding delay as required, informing about the selected path and a corresponding transport execution policy; when the service traffic arrives at the transport network, performing, according to a resource execution policy previously indicated, a corresponding scheduling and forwarding on the service traffic through the determined path by the transport layer function entity. when a new service session request arrives, selecting a path having enough remaining bandwidth by the transport control layer function entity to serve the service traffic, wherein the selected path has a corresponding service traffic class and a corresponding delay as required, informing about the selected path and a corresponding transport execution policy; when the service traffic arrives at the transport network, performing, according to a resource execution policy previously indicated, a corresponding scheduling and forwarding on the service traffic through the determined path by the transport layer function entity.
A magazine for embossing rollers (R; 251-257) comprising: - a plurality of support seats (249; 249A-249E) for embossing rollers, adjacent to one another according to an alignment direction; - a guide system for guiding the seats (249; 249A-249E) in a handling direction; characterized in that the seats (249; 249A-249E) are provided with mutual connecting members (25, 27) so as to be connected to, and released from, one another, in order to extract each seat from the magazine independently of the other seats. - a plurality of support seats (249; 249A-249E) for embossing rollers, adjacent to one another according to an alignment direction; - a guide system for guiding the seats (249; 249A-249E) in a handling direction;
A microfluidic chip mounting comprising: a blade part of, or for coupling to, a blade of a centrifuge, at a radial distance from an axis of the centrifuge, the blade adapted for mounting to the centrifuge for rotation about the axis, and defining a plane of the centrifuge; and a chip part for holding a planar microfluidic chip at an orientation having a normal not perpendicular to the axis; characterized in that the microfluidic chip mounting further comprises: a one degree of freedom (DoF) joint between the blade part and the chip part, the one DoF joint permitting the chip part to move with respect to the centrifuge blade, the motion including at least a 5° pivot projected onto the plane; and a force applicator bearing on the blade part or the axis of the centrifuge at one end, and the chip or chip part at a second end, the bearing on the chip or chip part being provided at a fixed set of one or more points for constraining the motion, where the fixed points do not surround, and are not surrounded by, any instant centre of rotation in the plane. a blade part of, or for coupling to, a blade of a centrifuge, at a radial distance from an axis of the centrifuge, the blade adapted for mounting to the centrifuge for rotation about the axis, and defining a plane of the centrifuge; and a chip part for holding a planar microfluidic chip at an orientation having a normal not perpendicular to the axis; characterized in that the microfluidic chip mounting further comprises: a one degree of freedom (DoF) joint between the blade part and the chip part, the one DoF joint permitting the chip part to move with respect to the centrifuge blade, the motion including at least a 5° pivot projected onto the plane; and a force applicator bearing on the blade part or the axis of the centrifuge at one end, and the chip or chip part at a second end, the bearing on the chip or chip part being provided at a fixed set of one or more points for constraining the motion, where the fixed points do not surround, and are not surrounded by, any instant centre of rotation in the plane. a one degree of freedom (DoF) joint between the blade part and the chip part, the one DoF joint permitting the chip part to move with respect to the centrifuge blade, the motion including at least a 5° pivot projected onto the plane; and a force applicator bearing on the blade part or the axis of the centrifuge at one end, and the chip or chip part at a second end, the bearing on the chip or chip part being provided at a fixed set of one or more points for constraining the motion, where the fixed points do not surround, and are not surrounded by, any instant centre of rotation in the plane.
A method comprising: providing a feedstock comprising a type-I cellulose; converting at least a portion of the type-I cellulose by contacting the feedstock with a fluid comprising water, wherein the water is at a temperature and pressure so as to form a first reactant mixture, wherein the first reactant mixture is at a temperature of 250°C to 450°C and at a pressure of 110 bar to 350 bar, and maintaining the temperature and the pressure for a period of time of 0.1 sec to 10 sec, quenching the first reactant mixture to a temperature of 30°C to 300°C to form a first product mixture comprising: i) a first liquid fraction; and ii) a first solid fraction; wherein the first solid fraction comprises a composition comprising a cellulose product, wherein the cellulose product comprises unconverted type-I cellulose and a type-II cellulose; and hydrolyzing, in a different step from the converting, at least a portion of the unconverted type-I cellulose of the first product mixture at the same or different conditions as the converting. providing a feedstock comprising a type-I cellulose; converting at least a portion of the type-I cellulose by contacting the feedstock with a fluid comprising water, wherein the water is at a temperature and pressure so as to form a first reactant mixture, wherein the first reactant mixture is at a temperature of 250°C to 450°C and at a pressure of 110 bar to 350 bar, and maintaining the temperature and the pressure for a period of time of 0.1 sec to 10 sec, quenching the first reactant mixture to a temperature of 30°C to 300°C to form a first product mixture comprising: i) a first liquid fraction; and ii) a first solid fraction; wherein the first solid fraction comprises a composition comprising a cellulose product, wherein the cellulose product comprises unconverted type-I cellulose and a type-II cellulose; and i) a first liquid fraction; and ii) a first solid fraction; wherein the first solid fraction comprises a composition comprising a cellulose product, wherein the cellulose product comprises unconverted type-I cellulose and a type-II cellulose; and hydrolyzing, in a different step from the converting, at least a portion of the unconverted type-I cellulose of the first product mixture at the same or different conditions as the converting.
A device for diagnosing signal status in measurement and control by a driven object, the device having: a signal generating means for generating a periodically vibrating voltage including a pulse voltage and alternating voltage connected to the primary side of a transformer; and a measuring means of which any one of current or voltage or resistance varies, or a driven object which converts change of state of a subject to be controlled into any one of change of current or voltage or resistance connected to the secondary side of the transformer; characterized in that the transformer is an insulation transformer of which the primary side is insulated from the secondary side and the primary winding is provided with an intermediate tap, and a current measuring means is connected to the intermediate tap to measure a current in the primary side of the transformer caused by a current flow in the measuring means or the driven object connected to the secondary side via a rectifying circuit, whereby change in any one of the current or voltage or resistance of the measuring means or the driven object is estimated and a soundness diagnosis of the measuring means or the driven object is performed based on the measurement result of the current measuring means.
Hearing aid, comprising: a carrier unit, at least one microphone unit, a vibrator unit provided on said carrier unit, wherein said vibrator unit is configured to apply vibrations to a pinna of an outer ear of a user by touching said pinna, and a directional speaker unit configured to direct sound towards an ear canal of the user and to attenuate sound towards said at least one microphone unit, and where the vibrations and the sound are provided into the same ear which pinna is stimulated by the vibrator unit. a carrier unit, at least one microphone unit, a vibrator unit provided on said carrier unit, wherein said vibrator unit is configured to apply vibrations to a pinna of an outer ear of a user by touching said pinna, and a directional speaker unit configured to direct sound towards an ear canal of the user and to attenuate sound towards said at least one microphone unit, and where the vibrations and the sound are provided into the same ear which pinna is stimulated by the vibrator unit.
A percutaneous absorption preparation comprising a support layer, a drug-containing layer, and a release layer, wherein: the drug-containing layer comprises donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, and a stabilizer selected from the group consisting of thiocyanate metal salt and dimethylthiourea.
A method for measuring material properties of a test sample and subsequently cooling the test sample using a device for controlling the temperature of a test sample in a measuring unit for measuring material properties of the test sample, comprising a measuring cell for receiving the test sample, at least one temperature controlling element, and a thermal storage element coupled to the temperature controlling element to transfer heat, wherein means are provided for changing the thermal resistance between the thermal storage element and the measuring cell in order to selectively couple or decouple the thermal storage element and the measuring cell in terms of heat transfer, wherein the ratio of the thermal capacity of the thermal storage element to the thermal capacity of the measuring cell is at least 2:1, preferably at least 5:1, comprising the steps of a) measuring the material properties of the test sample at a measuring temperature; b) before and/or during step a): cooling the thermal storage element in the state decoupled from the measuring cell in terms of heat transfer, by using the temperature controlling element; c) after steps a) and b): reducing the thermal resistance between the thermal storage element and the measuring cell in order to couple the thermal storage element and the measuring cell to transfer heat; d) continuously transferring heat from the measuring cell to the thermal storage element, whereby the test sample is cooled from the measuring temperature to a temperature suitable for removing the test sample; and e) removing the test sample. a) measuring the material properties of the test sample at a measuring temperature; b) before and/or during step a): cooling the thermal storage element in the state decoupled from the measuring cell in terms of heat transfer, by using the temperature controlling element; c) after steps a) and b): reducing the thermal resistance between the thermal storage element and the measuring cell in order to couple the thermal storage element and the measuring cell to transfer heat; d) continuously transferring heat from the measuring cell to the thermal storage element, whereby the test sample is cooled from the measuring temperature to a temperature suitable for removing the test sample; and e) removing the test sample.
Protection method for a touch panel device (151, 251, 351), the protection method comprising: monitoring for every position on the touch panel device (151, 251, 351) a number of user input actions (103, 203) and surface area sizes (104, 204) of the user input actions (103, 203), and moving input elements (152, 252, 253, 254, 352, 353, 354, 355) that are displayed on the touch panel device (151, 251, 351) from their original position (110, 310, 311, 312, 313) to an alternative position (115, 215, 216, 217, 315, 316, 317, 318) based on the monitored numbers and surface area sizes (104, 204). monitoring for every position on the touch panel device (151, 251, 351) a number of user input actions (103, 203) and surface area sizes (104, 204) of the user input actions (103, 203), and moving input elements (152, 252, 253, 254, 352, 353, 354, 355) that are displayed on the touch panel device (151, 251, 351) from their original position (110, 310, 311, 312, 313) to an alternative position (115, 215, 216, 217, 315, 316, 317, 318) based on the monitored numbers and surface area sizes (104, 204).
A method for preparing a supported metallocene catalyst, comprising: i) preparing a support supported with metallocene compounds 1 and 2 by reacting metallocene compounds 1 and 2 with the support; ii) preparing the support supported with the metallocene compounds land 2 and a co-catalyst 1 by reacting the support supported with metallocene compounds 1 and 2 with the co-catalyst 1; iii) preparing a catalyst precursor that is gradually supported with the metallocene compounds, the co-catalyst 1 and further metallocene compounds in the support by reacting the metallocene compounds 1 and 2 and the support supported with the metallocene compounds 1 and 2 and the co-catalyst 1; and iv) preparing a metallocene catalyst by reacting the catalyst precursor and a co-catalyst 2; wherein the co-catalyst 2 is a borate compound represented by Chemistry Figure 8; wherein the supported amount of the co-catalyst 2 is 0.2 to 10 mole, based on 1 mole of the transition metal that is supported in the metallocene compound, by the boron contained in the co-catalyst 2, and in which the metallocene compound 1 is [A-O-(CH 2) a -C 5 H 4] 2 ZrCl 2, in which a is an integer of 4∼8, and A is one selected from the group consisting of methoxymethyl, t-butoxymethyl, tetrahydropyranyl, tetrahydrofuranyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl and t-butyl, and the metallocene compound 2 is [(A'-D-(CH 2) a)](CH 3)X(C 5 Me 4)(NCMe 3)]TiCl 2, in which X is methylene, ethylene or silicon, D is oxygen or nitrogen atom, and A' is one selected from the group consisting of alkyl, alkenyl, aryl, alkylaryl, arylalkyl, alkylsilyl, arylsilyl of carbon number 1-20, hydrogen, methoxymethyl, t-butoxymethyl, tetrahydropranyl, tetrahydrofuranyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl and t-butyl; [Chemistry Figure 8] T+ - wherein in the above Chemistry Figure 8, T+ is a polyatomic ion having a valency of +1; B is boron in an oxidation state of +3 form; and Q is independently selected from the group consisting of hydride, dialkylamido, alkoxide, aryloxide, hydrocarbyl, halocarbyl and halo-substituted-hydrocarbyl radical, respectively, the above Q has below 20 carbons. i) preparing a support supported with metallocene compounds 1 and 2 by reacting metallocene compounds 1 and 2 with the support; ii) preparing the support supported with the metallocene compounds land 2 and a co-catalyst 1 by reacting the support supported with metallocene compounds 1 and 2 with the co-catalyst 1; iii) preparing a catalyst precursor that is gradually supported with the metallocene compounds, the co-catalyst 1 and further metallocene compounds in the support by reacting the metallocene compounds 1 and 2 and the support supported with the metallocene compounds 1 and 2 and the co-catalyst 1; and iv) preparing a metallocene catalyst by reacting the catalyst precursor and a co-catalyst 2;