A lung care system comprising: a ventilation gas circuit; a portable multiple use module including a portable chassis and a lung console, the lung console comprising a pneumatic connector comprising a set of six gas lumens comprising at least a lumen connected to a gas exchanger and a lumen connected to the ventilation gas circuit; a single use disposable module including: a first interface adapted to couple the single use disposable module with the multiple use module for electro-mechanical interoperation with the multiple use module by matching a lung perfusion module connector of the first interface with the pneumatic connector; and a lung chamber assembly having a second interface for allowing a flow of a perfusion fluid into the lung, a third interface for allowing ventilation of the lung with a ventilation gas, and a fourth interface for allowing a flow of the perfusion fluid away from the lung, wherein the lung console provides at least one of electrical, pneumatic, and mechanical control of the perfusion fluid and the ventilation gas in the ventilation gas circuit connected to the lung in the single use disposable module; and wherein the pneumatic connector is configured to provide pneumatic connections via the matching lung perfusion module connector to the single use disposable module and to permit rapid removal and hookup of the single use disposable module to the portable multiple use module. a ventilation gas circuit; a portable multiple use module including a portable chassis and a lung console, the lung console comprising a pneumatic connector comprising a set of six gas lumens comprising at least a lumen connected to a gas exchanger and a lumen connected to the ventilation gas circuit; a single use disposable module including: a first interface adapted to couple the single use disposable module with the multiple use module for electro-mechanical interoperation with the multiple use module by matching a lung perfusion module connector of the first interface with the pneumatic connector; and a lung chamber assembly having a second interface for allowing a flow of a perfusion fluid into the lung, a third interface for allowing ventilation of the lung with a ventilation gas, and a fourth interface for allowing a flow of the perfusion fluid away from the lung, wherein the lung console provides at least one of electrical, pneumatic, and mechanical control of the perfusion fluid and the ventilation gas in the ventilation gas circuit connected to the lung in the single use disposable module; and a first interface adapted to couple the single use disposable module with the multiple use module for electro-mechanical interoperation with the multiple use module by matching a lung perfusion module connector of the first interface with the pneumatic connector; and a lung chamber assembly having a second interface for allowing a flow of a perfusion fluid into the lung, a third interface for allowing ventilation of the lung with a ventilation gas, and a fourth interface for allowing a flow of the perfusion fluid away from the lung, wherein the lung console provides at least one of electrical, pneumatic, and mechanical control of the perfusion fluid and the ventilation gas in the ventilation gas circuit connected to the lung in the single use disposable module; and wherein the pneumatic connector is configured to provide pneumatic connections via the matching lung perfusion module connector to the single use disposable module and to permit rapid removal and hookup of the single use disposable module to the portable multiple use module.