A computer-implemented method of ensuring safe operation of industrial machinery in a workcell, the method comprising the steps of: a. acquiring, with at least some of a plurality of image sensors (102 1-3) proximate to the workcell, a first plurality of images of the workcell; b. registering the sensors (102 1-3) to each other based at least in part on the first plurality of images and, based at least in part on the registration, converting the first plurality of images to a common reference frame of the sensors (102 1-3); c. determining a transformation matrix for transforming the common reference frame of the sensors (102 1-3) to a global frame of the workcell; d. providing an image of a scene in the workcell; e. establishing a registration library comprising a plurality of images of the industrial machinery, each associated with at least one configuration parameter; f. computationally comparing a state of the industrial machinery in the image of the scene against states of the industrial machinery in the plurality of images in the registration library; g. identifying one of the plurality of images in the registration library providing a best matching state of the industrial machinery to the state of the industrial machinery in the image of the scene; h. registering the plurality of sensors (102 1-3) to the industrial machinery based at least in part on the configuration parameter corresponding to the identified image in the registration library; i. acquiring a second plurality of images during operation of the industrial machinery; and j. monitoring the industrial machinery during operation thereof based at least in part on the acquired second plurality of images, transformation, and registration of the sensors (102 1-3) to the industrial machinery. a. acquiring, with at least some of a plurality of image sensors (102 1-3) proximate to the workcell, a first plurality of images of the workcell; b. registering the sensors (102 1-3) to each other based at least in part on the first plurality of images and, based at least in part on the registration, converting the first plurality of images to a common reference frame of the sensors (102 1-3); c. determining a transformation matrix for transforming the common reference frame of the sensors (102 1-3) to a global frame of the workcell; d. providing an image of a scene in the workcell; e. establishing a registration library comprising a plurality of images of the industrial machinery, each associated with at least one configuration parameter; f. computationally comparing a state of the industrial machinery in the image of the scene against states of the industrial machinery in the plurality of images in the registration library; g. identifying one of the plurality of images in the registration library providing a best matching state of the industrial machinery to the state of the industrial machinery in the image of the scene; h. registering the plurality of sensors (102 1-3) to the industrial machinery based at least in part on the configuration parameter corresponding to the identified image in the registration library; i. acquiring a second plurality of images during operation of the industrial machinery; and j. monitoring the industrial machinery during operation thereof based at least in part on the acquired second plurality of images, transformation, and registration of the sensors (102 1-3) to the industrial machinery.