A compound of Formula wherein: - R 1 is selected from the group consisting of C 1-2 alkyl, C 2 alkenyl, C 2 alkynyl, CN, CF 3, NO 2, F, Cl, Br, and I; - R 2 is selected from the group consisting of C 1-5 alkyl optionally be substituted with one or more, identical or different, substituents R 6, C 2-5 alkenyl optionally be substituted with one or more, identical or different, substituents R 6, C 2-5 alkynyl optionally be substituted with one or more, identical or different, substituents R 6, C 3-5 cycloalkyl optionally substituted with one or more, identical or different, substituents R 6, phenyl optionally substituted with one or more, identical or different, substituents R 9, and 5-6 membered aromatic heterocycle optionally substituted with one or more, identical or different, substituents R 7; - R 3 is selected from the group consisting of deuterium, Cl and F; - R 4 is selected from the group consisting of H, deuterium, C 1-5 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, and C 3-5 cycloalkyl, each of which may be optionally substituted with one or more, identical or different, substituents R 7; - R 5 is selected from the group consisting of H, C 1-5 alkyl optionally substituted with one or more, identical or different, substituents R 8, C 2-5 alkenyl optionally substituted with one or more, identical or different, substituents R 8, C 2-5 alkynyl optionally substituted with one or more, identical or different, substituents R 8, C 3-6 cycloalkyl optionally substituted with one or more, identical or different, substituents R 8, phenyl optionally substituted with one or more, identical or different, substituents R 9, and benzyl optionally substituted with one or more, identical or different, substituents R 9; - R 6 is independently selected from the group consisting of deuterium, F, -CN, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl, wherein the -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R 8; - R 7 is independently selected from the group consisting deuterium, F, Cl, -CN, C 3-5 cycloalkyl, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl, wherein the C 3-5 cycloalkyl, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, - S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R 8; - R 8 is independently selected from the group consisting of deuterium and F; - R 9 is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I, and F; and - n is an integer 0, 1, 2, or 3; or a pharmaceutically acceptable salt, hydrate, polymorph, tautomer, or solvate thereof. - R 1 is selected from the group consisting of C 1-2 alkyl, C 2 alkenyl, C 2 alkynyl, CN, CF 3, NO 2, F, Cl, Br, and I; - R 2 is selected from the group consisting of C 1-5 alkyl optionally be substituted with one or more, identical or different, substituents R 6, C 2-5 alkenyl optionally be substituted with one or more, identical or different, substituents R 6, C 2-5 alkynyl optionally be substituted with one or more, identical or different, substituents R 6, C 3-5 cycloalkyl optionally substituted with one or more, identical or different, substituents R 6, phenyl optionally substituted with one or more, identical or different, substituents R 9, and 5-6 membered aromatic heterocycle optionally substituted with one or more, identical or different, substituents R 7; - R 3 is selected from the group consisting of deuterium, Cl and F; - R 4 is selected from the group consisting of H, deuterium, C 1-5 alkyl, C 2-5 alkenyl, C 2-5 alkynyl, and C 3-5 cycloalkyl, each of which may be optionally substituted with one or more, identical or different, substituents R 7; - R 5 is selected from the group consisting of H, C 1-5 alkyl optionally substituted with one or more, identical or different, substituents R 8, C 2-5 alkenyl optionally substituted with one or more, identical or different, substituents R 8, C 2-5 alkynyl optionally substituted with one or more, identical or different, substituents R 8, C 3-6 cycloalkyl optionally substituted with one or more, identical or different, substituents R 8, phenyl optionally substituted with one or more, identical or different, substituents R 9, and benzyl optionally substituted with one or more, identical or different, substituents R 9; - R 6 is independently selected from the group consisting of deuterium, F, -CN, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl, wherein the -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R 8; - R 7 is independently selected from the group consisting deuterium, F, Cl, -CN, C 3-5 cycloalkyl, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, -S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl, wherein the C 3-5 cycloalkyl, -O-C 1-5 alkyl, -O-C 3-5 cycloalkyl, - S-C 1-5 alkyl, and -S-C 3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R 8; - R 8 is independently selected from the group consisting of deuterium and F; - R 9 is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I, and F; and - n is an integer 0, 1, 2, or 3;