mhurhangee/ep-ind-claims huggingface dataset:
A stent graft comprising: a wall defining a generally tubular lumen, the wall defining a fenestration for providing fluid communication between the lumen and a branch vessel, the fenestration having a circumferential periphery; a resilient reinforcing wire curved to follow the periphery of the fenestration thereby defining a reinforcing ring; and a marker winding wound helically around the reinforcing wire of the reinforcing ring such that the marker winding forms a curved helix around the resilient reinforcing wire, the marker winding being wound from a marker wire, wherein the marker wire is orientated transverse to the reinforcing wire in both a deployed shape for use and a squashed shape for loading into a delivery device, wherein the marker winding defines a curved passageway, the curved passageway having an internal diameter D, wherein the marker winding is helically wound with a pitch providing at least one winding per length D along the reinforcing wire of the reinforcing ring; whereby the marker winding is viewable on an image display system employing electromagnetic radiation so as to indicate the location of the periphery of the fenestration. a wall defining a generally tubular lumen, the wall defining a fenestration for providing fluid communication between the lumen and a branch vessel, the fenestration having a circumferential periphery; a resilient reinforcing wire curved to follow the periphery of the fenestration thereby defining a reinforcing ring; and a marker winding wound helically around the reinforcing wire of the reinforcing ring such that the marker winding forms a curved helix around the resilient reinforcing wire, the marker winding being wound from a marker wire, wherein the marker wire is orientated transverse to the reinforcing wire in both a deployed shape for use and a squashed shape for loading into a delivery device, wherein the marker winding defines a curved passageway, the curved passageway having an internal diameter D, wherein the marker winding is helically wound with a pitch providing at least one winding per length D along the reinforcing wire of the reinforcing ring; whereby the marker winding is viewable on an image display system employing electromagnetic radiation so as to indicate the location of the periphery of the fenestration.
Canagliflozin for use in a method for treating hyperuricemia or a related disorder, wherein the method comprises administering to a subject in need thereof, a therapeutically effective amount of co-therapy comprising canagliflozin and probenecid, wherein the term "hyperuricemia or a related disorder" is defined as any disease, disorder or condition characterized by elevated, i.e. above normal, levels serum uric acid.
An implantable stimulation arrangement for generating electrode stimulation signals for an implanted electrode array having a plurality of stimulation electrodes, the arrangement comprising: a filter bank pre-processor for processing an input acoustic audio signal to generate a plurality of band pass signals each corresponding to an associated band of audio frequencies; a signal envelope module for computing a corresponding signal envelope for each band pass signal; a stimulation pulse generator for extracting stimulation signal information as a function of rate of change of the signal envelopes to generate stimulation event signals defining electrode stimulation timings and amplitudes for a plurality of the stimulation electrodes, characterised by an envelope filter for smoothing and zero referencing the signal envelopes computed by the signal envelope module. a filter bank pre-processor for processing an input acoustic audio signal to generate a plurality of band pass signals each corresponding to an associated band of audio frequencies; a signal envelope module for computing a corresponding signal envelope for each band pass signal; a stimulation pulse generator for extracting stimulation signal information as a function of rate of change of the signal envelopes to generate stimulation event signals defining electrode stimulation timings and amplitudes for a plurality of the stimulation electrodes, characterised by an envelope filter for smoothing and zero referencing the signal envelopes computed by the signal envelope module.
A delayed release pharmaceutical composition for oral administration comprising Dimethyl fumarate, in a tablet core of diameter 5-10mm wherein said core is coated with two pH-dependent gastro-resistant polymeric layers, wherein the weight gain of first polymeric coating layer is 4-8% w/w, the weight gain of second polymeric coating layer is 5-15% w/w and Dimethyl fumarate has particle size D90 value of less than 300 μm measured with laser light diffraction.
A pharmaceutical composition for use in the treatment of a lymphoma associated with CD20 expression comprising: an effective amount of a first isolated antibody having a variable domain that specifically binds the extracellular domain of native human FcγRIIB with greater affinity than said variable domain binds native human FcγRIIA, wherein said first isolated antibody comprises: a heavy chain comprising the amino acid sequence of SEQ ID NO:68 or SEQ ID NO:70; and a light chain comprising the amino acid sequence of SEQ ID NO:62 or SEQ ID NO:66; an effective amount of a second isolated antibody that specifically binds human CD20; and a pharmaceutically acceptable carrier, wherein said effective amounts of said first isolated antibody and said second isolated antibody cause said pharmaceutical composition to mediate a synergistically increased tumor volume reduction relative to the tumor volume reductions mediated by: a pharmaceutical composition comprising said effective amount of said first antibody but lacking said effective amount of said second antibody; and a pharmaceutical composition comprising said effective amount of said second antibody but lacking said effective amount of said first antibody. an effective amount of a first isolated antibody having a variable domain that specifically binds the extracellular domain of native human FcγRIIB with greater affinity than said variable domain binds native human FcγRIIA, wherein said first isolated antibody comprises: a heavy chain comprising the amino acid sequence of SEQ ID NO:68 or SEQ ID NO:70; and a light chain comprising the amino acid sequence of SEQ ID NO:62 or SEQ ID NO:66; a heavy chain comprising the amino acid sequence of SEQ ID NO:68 or SEQ ID NO:70; and a light chain comprising the amino acid sequence of SEQ ID NO:62 or SEQ ID NO:66; an effective amount of a second isolated antibody that specifically binds human CD20; and a pharmaceutically acceptable carrier, wherein said effective amounts of said first isolated antibody and said second isolated antibody cause said pharmaceutical composition to mediate a synergistically increased tumor volume reduction relative to the tumor volume reductions mediated by: a pharmaceutical composition comprising said effective amount of said first antibody but lacking said effective amount of said second antibody; and a pharmaceutical composition comprising said effective amount of said second antibody but lacking said effective amount of said first antibody. a pharmaceutical composition comprising said effective amount of said first antibody but lacking said effective amount of said second antibody; and a pharmaceutical composition comprising said effective amount of said second antibody but lacking said effective amount of said first antibody.
An insulation fault locating system for a branched IT system with a subsystem (S 1,.., S n), comprising a differential current measuring device (M 1,.., M n) arranged in the subsystem (S 1,.., S n) for registering a differential current measuring signal, characterized in that a test signal generator (G 1,.., G n) for serial feeding of a test signal is arranged in the subsystem (S 1,.., S n)of the branched IT system and that the subsystem (S 1,.., S n) has a circuit wired blocking device (B 1,.., B n) which limits the effectiveness of the test signal fed into said subsystem (S 1,.., S n) to said subsystem (S 1,.., S n).
Device for securing at least one sling for transporting a load under a helicopter, said securing device comprising: - at least one first strap and at least one second strap, each strap (31, 32) extending longitudinally and comprising an end for joining (31A, 32A) to the helicopter and a connecting end (31B, 32B), - a connecting mechanism configured, in a closed state, to connect the connecting ends (31B, 32B) of the straps (31, 32) to form an overall securing strap capable of supporting a sling and, in a open state, to release the connecting ends (31B, 32B) of the straps (31, 32) to drop the sling, the connecting mechanism being suited to withstand in the closed state a tractive force of 1500 kg, and - an actuator configured to open the connecting mechanism following an input of mechanical force, the connecting mechanism comprising a plurality of rings (331, 332, 333) mounted in cascade configured to reduce the force of resistance to the opening of the connecting mechanism induced by the support of the sling so that the input mechanical force is less than 20 kg for a tractive force of 1500 kg induced by the support of the sling, the connecting mechanism comprises at least a first ring, a second ring and a third ring, the first ring having a diameter greater than that of the second ring and the second ring having a diameter greater than that of the third ring, the first ring being hinged at the level of the connecting end of the first strap whereas the second and third rings (332, 333) are hinged at the level of the connecting end of the second strap. - at least one first strap and at least one second strap, each strap (31, 32) extending longitudinally and comprising an end for joining (31A, 32A) to the helicopter and a connecting end (31B, 32B), - a connecting mechanism configured, in a closed state, to connect the connecting ends (31B, 32B) of the straps (31, 32) to form an overall securing strap capable of supporting a sling and, in a open state, to release the connecting ends (31B, 32B) of the straps (31, 32) to drop the sling, the connecting mechanism being suited to withstand in the closed state a tractive force of 1500 kg, and - an actuator configured to open the connecting mechanism following an input of mechanical force, the connecting mechanism comprising a plurality of rings (331, 332, 333) mounted in cascade configured to reduce the force of resistance to the opening of the connecting mechanism induced by the support of the sling so that the input mechanical force is less than 20 kg for a tractive force of 1500 kg induced by the support of the sling, the connecting mechanism comprises at least a first ring, a second ring and a third ring, the first ring having a diameter greater than that of the second ring and the second ring having a diameter greater than that of the third ring, the first ring being hinged at the level of the connecting end of the first strap whereas the second and third rings (332, 333) are hinged at the level of the connecting end of the second strap.
A process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, in the presence of hydrogen, a nitrogen-containing compound, and a catalyst, wherein the presence of the nitrogen-containing compound, expressed in a molar ratio relative to the first functional group in the organic feed substrate, at least during a period of the reaction as long as the conversion of the organic feed substrate has not yet reached 80%, is maintained at a level of at most 1.2; wherein the reductive amination is performed on a halo-benzaldehyde.
An apparatus for additive manufacturing, comprising: a component arranged on a platform; and a nozzle operable to deposit a printed feature onto the component, the nozzle comprising: a plasma gas tube operable to provide plasma gas to a plasma flame; a source material tube arranged concentrically inside the plasma gas tube such that source material passes through the plasma flame; and a sheath gas tube arranged concentrically between the plasma gas tube and the source material tube, the sheath gas tube operable to carry a sheath gas, wherein the source material is a precursor material, and the apparatus is configured such that the source material is changed into a final material of the printed feature as it passes through the nozzle in use, wherein the change from precursor material to the final material of the printed feature is configured to occur by reaction of the sheat gas with the precursor material as it passes through the plasma flame local to the surface of the substrate of the component. a component arranged on a platform; and a nozzle operable to deposit a printed feature onto the component, the nozzle comprising: a plasma gas tube operable to provide plasma gas to a plasma flame; a source material tube arranged concentrically inside the plasma gas tube such that source material passes through the plasma flame; and a sheath gas tube arranged concentrically between the plasma gas tube and the source material tube, the sheath gas tube operable to carry a sheath gas, wherein the source material is a precursor material, and the apparatus is configured such that the source material is changed into a final material of the printed feature as it passes through the nozzle in use, wherein the change from precursor material to the final material of the printed feature is configured to occur by reaction of the sheat gas with the precursor material as it passes through the plasma flame local to the surface of the substrate of the component. a plasma gas tube operable to provide plasma gas to a plasma flame; a source material tube arranged concentrically inside the plasma gas tube such that source material passes through the plasma flame; and a sheath gas tube arranged concentrically between the plasma gas tube and the source material tube, the sheath gas tube operable to carry a sheath gas, wherein the source material is a precursor material, and the apparatus is configured such that the source material is changed into a final material of the printed feature as it passes through the nozzle in use, wherein the change from precursor material to the final material of the printed feature is configured to occur by reaction of the sheat gas with the precursor material as it passes through the plasma flame local to the surface of the substrate of the component.
A coordinate registration system, comprising: a shape sensing device (104, 504) comprising at least one position sensor (450, 505) for providing corresponding sensor information indicative of a position of the at least one position sensor (450, 505); a registration fixture having an asymmetric channel, wherein the asymmetric channel extends through a body of the registration fixture, is configured to receive at least part of the SSD and defines a registration path, the registration fixture configured to be attached to a registrant object defining a workspace; and a controller which is configured to: sense a shape of a path traversed by the SSD inserted into the asymmetric channel based upon the SI obtained from the at least one position sensor (450, 505) when the at least one position sensor is situated within the asymmetric channel, determine whether the sensed shape of the path corresponds with a known shape selected from one or more known shapes, and perform a coordinate registration when it is determined that the sensed shape of the path corresponds with the selected known shape. a shape sensing device (104, 504) comprising at least one position sensor (450, 505) for providing corresponding sensor information indicative of a position of the at least one position sensor (450, 505); a registration fixture having an asymmetric channel, wherein the asymmetric channel extends through a body of the registration fixture, is configured to receive at least part of the SSD and defines a registration path, the registration fixture configured to be attached to a registrant object defining a workspace; and a controller which is configured to: sense a shape of a path traversed by the SSD inserted into the asymmetric channel based upon the SI obtained from the at least one position sensor (450, 505) when the at least one position sensor is situated within the asymmetric channel, determine whether the sensed shape of the path corresponds with a known shape selected from one or more known shapes, and perform a coordinate registration when it is determined that the sensed shape of the path corresponds with the selected known shape. sense a shape of a path traversed by the SSD inserted into the asymmetric channel based upon the SI obtained from the at least one position sensor (450, 505) when the at least one position sensor is situated within the asymmetric channel, determine whether the sensed shape of the path corresponds with a known shape selected from one or more known shapes, and perform a coordinate registration when it is determined that the sensed shape of the path corresponds with the selected known shape.
A system for generating a weld during a start of a welding process, the system comprising: a power circuit for generating welding output power; and a control circuit in communication with the power circuit to control, characterized in that the control circuit is configured to initially provide a welding parameter at a start-up value during the start of the welding process; and in that the control circuit is further configured to provide the welding parameter at a normal welding value when the control circuit determines that welding energy output power exceeds an energy output threshold. a power circuit for generating welding output power; and a control circuit in communication with the power circuit to control, characterized in that the control circuit is configured to initially provide a welding parameter at a start-up value during the start of the welding process; and in that the control circuit is further configured to provide the welding parameter at a normal welding value when the control circuit determines that welding energy output power exceeds an energy output threshold.
Oil-lubricated bearing assembly comprising a bearing housing, at least one rotary bearing (14, 14A, 14B, 14C) received in a cavity of the bearing housing, the rotary bearing (14, 14A, 14B, 14C) having at least one stationary outer race facing a revolution axis of the bearing assembly, wherein in an operational position of the bearing housing the revolution axis is horizontal, wherein the bearing housing comprises an oil outlet for letting oil out of the bearing housing, wherein the oil outlet comprises a channel through a wall of the bearing housing, and a mouth section having an edge that surrounds an opening located in the bearing housing for communication between the cavity of the bearing housing and the channel, wherein in the operational position, a horizontal reference plane intersects the edge at at least one intersection point and is such that every point of the edge is in or above the horizontal reference plane, and the horizontal plane is at a distance above a lowermost part of the channel, wherein the reference plane is at a distance above a lowermost part of the outer race characterised in that the opening has an orthogonal projection on the horizontal reference plane with a projected area, which is strictly greater than an inner cross-sectional area of a lower part of a cross-section of the channel that is below the horizontal reference plane.
A castor with a wheel and a wheel axle, wherein a journal projecting upwards beyond a housing of the castor in the normal position of use is provided, wherein a sleeve spaced radially by a damping material arranged between the sleeve and the journal is seated on the journal, wherein the sleeve is also spaced axially upwards from the journal by the damping material arranged between the sleeve and the journal, the damping material being arranged in such a way that any axial and/or radial contact between the journal and the sleeve is prevented, in that the journal has an upwardly facing journal end face, characterized in that the damping material is arranged in overlapping relationship with the journal end face, in that the sleeve has a downwardly facing sleeve end face, in that the damping material is arranged in overlapping relationship with the sleeve end face, and in that the damping material, which is further formed in overlapping relationship with the journal end face, leaves a through-opening running in the direction of the central axis (x) of the journal.
An anchoring system for anchoring a protective sheath within the bowel proximal to a region of bowel that requires protection from fecal flow, comprising: a sleeve having an inner surface defining a first lumen; a first annular sealing mechanism disposed at a proximal end of the sleeve; a second annular sealing mechanism disposed at a distal end of the sleeve; a pressure tube in fluid connection with an outer surface of the sleeve; a sheath in mechanical connection with the sleeve, the sheath forming a second lumen, the second lumen being in fluid connection with the first lumen; and open-cell foam disposed on the outer surface of the sleeve, wherein application of negative pressure to the pressure tube causes a seal to form between the first and second annular sealing mechanisms (108, 110) and an inner surface of a tissue cavity, and wherein the application of negative pressure to the pressure tube creates a frictional force that resists displacement of the sleeve, and wherein the sheath protects the inner surface of the tissue cavity from fecal flow distal to the sleeve. a sleeve having an inner surface defining a first lumen; a first annular sealing mechanism disposed at a proximal end of the sleeve; a second annular sealing mechanism disposed at a distal end of the sleeve; a pressure tube in fluid connection with an outer surface of the sleeve; a sheath in mechanical connection with the sleeve, the sheath forming a second lumen, the second lumen being in fluid connection with the first lumen; and open-cell foam disposed on the outer surface of the sleeve, wherein application of negative pressure to the pressure tube causes a seal to form between the first and second annular sealing mechanisms (108, 110) and an inner surface of a tissue cavity, and