A compound having formula (le) or a pharmaceutically acceptable salt, solvate or optical isomer thereof, wherein the variables in formula (le) have the meanings as follows: R w is -NR 10 SO 2 R 12 or -N=S(=O)R 10 NR 10 R 10; R x, R y, R z are selected from: a) R x is halogen, R y is halogen and R z is H; b) R x is halogen, R z is halogen and R y is H; c) R x is halogen, R z is H and R y is H; and d) R x is halogen, R y is halogen and R z is halogen; R 1 is H, alkyl or heterocycloalkyl having 4 to 5 ring carbon atoms and 1 or 2 heteroatoms independently selected from O, NH or N-alkyl; R 4 is H, halogen, or alkyl; R 5 is phenyl which is optionally substituted with 1, 2 or 3 groups independently selected from alkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylSO(=NR 10)-, alkylsulfonyl-NR 10 -, NR 10 R 10, R 10 R 10 NSO 2 -, R 10 R 11 NSO 2 -, alkyl-C(=O)-NR 10 SO 2 -, R 10 R 11 N(C=O)-, alkoxy, benzyloxy, haloalkoxy, -OCH 2 O- (methylenedioxy attached in neighboring positions to the phenyl ring), -OCH 2 CH 2 O- (ethylenedioxy attached in neighboring positions to the phenyl ring), -NO 2, -COOR 10, -COOR 14, R 10 R 10 N(C=O)-, -CN, alkylcarbonyl-NR 10 -, tetrazolyl, alkenyl, carboxyl-substituted alkenyl, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl, or a heteroaromatic 5- or 6-membered monocyclic group having 1, 2 or 3 heteroatoms independently selected from O, N and S which group is optionally substituted with 1 or 2 groups independently selected from alkyl, haloalkyl, alkoxy, -NR 10 R 10, halogen, -NR 10 -cycloalkyl, tetrazolyl, -O-alkylene-NR 10 R 10, -NR 10 -alkylene-O-alkyl, -CN, -CONR 10 R 10, -COOR 10, alkylSO(=NR 10)-, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl; R 6 is H, or alkyl; R 10 at each occurrence independently is H or C 1 -C 6 alkyl,; R 11 is alkyl which is substituted with 1, 2 or 3 hydroxy groups; R 12 is H, C 1 -C 6 alkyl or phenyl-C 1 -C 6 alkyl; and R 14 is alkyl which is substituted with 1 or 2 groups independently selected from -NR 10 R 10, hydroxy or alkoxy. R w is -NR 10 SO 2 R 12 or -N=S(=O)R 10 NR 10 R 10; R x, R y, R z are selected from: a) R x is halogen, R y is halogen and R z is H; b) R x is halogen, R z is halogen and R y is H; c) R x is halogen, R z is H and R y is H; and d) R x is halogen, R y is halogen and R z is halogen; a) R x is halogen, R y is halogen and R z is H; b) R x is halogen, R z is halogen and R y is H; c) R x is halogen, R z is H and R y is H; and d) R x is halogen, R y is halogen and R z is halogen; R 1 is H, alkyl or heterocycloalkyl having 4 to 5 ring carbon atoms and 1 or 2 heteroatoms independently selected from O, NH or N-alkyl; R 4 is H, halogen, or alkyl; H, halogen, or alkyl; R 5 is phenyl which is optionally substituted with 1, 2 or 3 groups independently selected from alkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylSO(=NR 10)-, alkylsulfonyl-NR 10 -, NR 10 R 10, R 10 R 10 NSO 2 -, R 10 R 11 NSO 2 -, alkyl-C(=O)-NR 10 SO 2 -, R 10 R 11 N(C=O)-, alkoxy, benzyloxy, haloalkoxy, -OCH 2 O- (methylenedioxy attached in neighboring positions to the phenyl ring), -OCH 2 CH 2 O- (ethylenedioxy attached in neighboring positions to the phenyl ring), -NO 2, -COOR 10, -COOR 14, R 10 R 10 N(C=O)-, -CN, alkylcarbonyl-NR 10 -, tetrazolyl, alkenyl, carboxyl-substituted alkenyl, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl, or alkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylSO(=NR 10)-, alkylsulfonyl-NR 10 -, NR 10 R 10, R 10 R 10 NSO 2 -, R 10 R 11 NSO 2 -, alkyl-C(=O)-NR 10 SO 2 -, R 10 R 11 N(C=O)-, alkoxy, benzyloxy, haloalkoxy, -OCH 2 O- (methylenedioxy attached in neighboring positions to the phenyl ring), -OCH 2 CH 2 O- (ethylenedioxy attached in neighboring positions to the phenyl ring), -NO 2, -COOR 10, -COOR 14, R 10 R 10 N(C=O)-, -CN, alkylcarbonyl-NR 10 -, tetrazolyl, alkenyl, carboxyl-substituted alkenyl, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl, or a heteroaromatic 5- or 6-membered monocyclic group having 1, 2 or 3 heteroatoms independently selected from O, N and S which group is optionally substituted with 1 or 2 groups independently selected from alkyl, haloalkyl, alkoxy, -NR 10 R 10, halogen, -NR 10 -cycloalkyl, tetrazolyl, -O-alkylene-NR 10 R 10, -NR 10 -alkylene-O-alkyl, -CN, -CONR 10 R 10, -COOR 10, alkylSO(=NR 10)-, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl; alkyl, haloalkyl, alkoxy, -NR 10 R 10, halogen, -NR 10 -cycloalkyl, tetrazolyl, -O-alkylene-NR 10 R 10, -NR 10 -alkylene-O-alkyl, -CN, -CONR 10 R 10, -COOR 10, alkylSO(=NR 10)-, -CONR 10 -O-alkylene-OH, and -CONR 10 -O-alkylene-O-alkyl; R 6 is H, or alkyl; R 10 at each occurrence independently is H or C 1 -C 6 alkyl,; R 11 is alkyl which is substituted with 1, 2 or 3 hydroxy groups; R 12 is H, C 1 -C 6 alkyl or phenyl-C 1 -C 6 alkyl; and R 14 is alkyl which is substituted with 1 or 2 groups independently selected from -NR 10 R 10, hydroxy or alkoxy.