An isolated antibody or a fragment thereof binding to a SR1-B1 target region and comprising a first variable region and a second variable region, wherein a) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 1, a second CDR comprising amino acids 50-66 of SEQ ID NO: 1, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 1; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 1, a second CDR comprising amino acids 186-192 of SEQ ID NO: 1, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 1; b) said first variable region is a V h region comprising a first CDR comprising amino acids 31-37 of SEQ ID NO: 2, a second CDR comprising amino acids 52-67 of SEQ ID NO: 2, and a third CDR comprising the amino acids 100-114 of SEQ ID NO: 2; and said second variable region is a V l region comprising a first CDR comprising amino acids 164-176 of SEQ ID NO: 2, a second CDR comprising amino acids 192-198 of SEQ ID NO: 2, and a third CDR comprising amino acids 231-241 of SEQ ID NO: 2; c) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 3, a second CDR comprising amino acids 50-66 of SEQ ID NO: 3, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 3; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 3, a second CDR comprising amino acids 186-192 of SEQ ID NO: 3, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 3; or d) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 4, a second CDR comprising amino acids 50-66 of SEQ ID NO: 4, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 4; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 4, a second CDR comprising amino acids 186-192 of SEQ ID NO: 4, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 4. a) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 1, a second CDR comprising amino acids 50-66 of SEQ ID NO: 1, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 1; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 1, a second CDR comprising amino acids 186-192 of SEQ ID NO: 1, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 1; b) said first variable region is a V h region comprising a first CDR comprising amino acids 31-37 of SEQ ID NO: 2, a second CDR comprising amino acids 52-67 of SEQ ID NO: 2, and a third CDR comprising the amino acids 100-114 of SEQ ID NO: 2; and said second variable region is a V l region comprising a first CDR comprising amino acids 164-176 of SEQ ID NO: 2, a second CDR comprising amino acids 192-198 of SEQ ID NO: 2, and a third CDR comprising amino acids 231-241 of SEQ ID NO: 2; c) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 3, a second CDR comprising amino acids 50-66 of SEQ ID NO: 3, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 3; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 3, a second CDR comprising amino acids 186-192 of SEQ ID NO: 3, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 3; or d) said first variable region is a V h region comprising a first CDR comprising amino acids 31-35 of SEQ ID NO: 4, a second CDR comprising amino acids 50-66 of SEQ ID NO: 4, and a third CDR comprising amino acids 99-108 of SEQ ID NO: 4; and said second variable region is a V l region comprising a first CDR comprising amino acids 158-170 of SEQ ID NO: 4, a second CDR comprising amino acids 186-192 of SEQ ID NO: 4, and a third CDR comprising amino acids 225-235 of SEQ ID NO: 4.