A compound of the Formula (Ia): wherein: X is alkylene optionally interrupted by one or more -O- groups; n is an integer from 0 to 4; R 1-1 is selected from the group consisting of: hydrogen, alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, -N(CH 3)(OCH 3), and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, -NH-SO 2 -R 1-4, -NH-C -R 1-4, -NH-C -NH 2, -NH-C -NH-R 1-4, and -N 3; R 1-4 is selected from the group consisting of: alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, and -N 3; R is selected from the group consisting of: fluoro, alkyl, haloalkyl, alkoxy, and -N(R 9) 2; R 2 is selected from the group consisting of: hydrogen, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, alkylene-Y-alkyl, alkylene-Y-alkenyl, alkylene-Y-aryl, and alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: hydroxy, halogen, -N(R 3) 2, -C -C 1-10 alkyl, -C -O-C 1-10 alkyl, -N(R 3)-C -C 1-10 alkyl, -N 3, aryl, heteroaryl, heterocyclyl, -C -aryl, and -C -heteroaryl; wherein: Y is -O- or -S 0-2 -; R 3 is selected from the group consisting of: hydrogen, C 1-10 alkyl, and C 2-10 alkenyl; and R 9 is selected from the group consisting of hydrogen and alkyl; or a pharmaceutically acceptable salt thereof. X is alkylene optionally interrupted by one or more -O- groups; n is an integer from 0 to 4; R 1-1 is selected from the group consisting of: hydrogen, alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, -N(CH 3)(OCH 3), and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, -NH-SO 2 -R 1-4, -NH-C -R 1-4, -NH-C -NH 2, -NH-C -NH-R 1-4, and -N 3; hydrogen, alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, -N(CH 3)(OCH 3), and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, -NH-SO 2 -R 1-4, -NH-C -R 1-4, -NH-C -NH 2, -NH-C -NH-R 1-4, and -N 3; halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, -NH-SO 2 -R 1-4, -NH-C -R 1-4, -NH-C -NH 2, -NH-C -NH-R 1-4, and -N 3; R 1-4 is selected from the group consisting of: alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, and -N 3; alkyl, aryl, alkylene-aryl, heteroaryl, alkylene-heteroaryl, and alkyl, aryl, alkylene-aryl, heteroaryl, or alkylene-heteroaryl substituted by one or more substituents selected from the group consisting of: halogen, cyano, nitro, alkoxy, dialkylamino, alkylthio, haloalkyl, haloalkoxy, alkyl, and -N 3; R is selected from the group consisting of: fluoro, alkyl, haloalkyl, alkoxy, and -N(R 9) 2; fluoro, alkyl, haloalkyl, alkoxy, and -N(R 9) 2; R 2 is selected from the group consisting of: hydrogen, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, alkylene-Y-alkyl, alkylene-Y-alkenyl, alkylene-Y-aryl, and alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: hydroxy, halogen, -N(R 3) 2, -C -C 1-10 alkyl, -C -O-C 1-10 alkyl, -N(R 3)-C -C 1-10 alkyl, -N 3, aryl, heteroaryl, heterocyclyl, -C -aryl, and -C -heteroaryl; wherein: Y is -O- or -S 0-2 -; R 3 is selected from the group consisting of: hydrogen, C 1-10 alkyl, and C 2-10 alkenyl; and hydrogen, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, alkylene-Y-alkyl, alkylene-Y-alkenyl, alkylene-Y-aryl, and alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: hydroxy, halogen, -N(R 3) 2, -C -C 1-10 alkyl, -C -O-C 1-10 alkyl, -N(R 3)-C -C 1-10 alkyl, -N 3, aryl, heteroaryl, heterocyclyl, -C -aryl, and -C -heteroaryl; hydroxy, halogen, -N(R 3) 2, -C -C 1-10 alkyl, -C -O-C 1-10 alkyl, -N(R 3)-C -C 1-10 alkyl, -N 3, aryl, heteroaryl, heterocyclyl, -C -aryl, and -C -heteroaryl; Y is -O- or -S 0-2 -; R 3 is selected from the group consisting of: hydrogen, C 1-10 alkyl, and C 2-10 alkenyl; and hydrogen, C 1-10 alkyl, and C 2-10 alkenyl; and R 9 is selected from the group consisting of hydrogen and alkyl;