A method for determining the onset or a predisposition to the onset of a colorectal adenoma in an individual, said method comprising a) measuring the level of expression of: (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60; or (ii) a nucleic acid molecule comprising a nucleotide sequence capable of hybridising to SEQ ID NO:60 under high stringency conditions at 42°C in a biological sample from said individual wherein an increase in the level of expression of said nucleic acid molecule relative to the normal level of expression of said nucleic acid molecule in an individual is indicative of the onset or predisposition to the onset of a colorectal adenoma; or b) detecting the co-expression of: (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more nucleic acid molecules comprising a nucleotide sequence as set forth in any one of SEQ ID NOs: 1-2, SEQ ID NOs: 4-6, SEQ ID NOs: 7-32, SEQ ID NOs: 35-37, SEQ ID NO: 38, SEQ ID NOs: 40-43, SEQ ID NOs: 45-49, SEQ ID NOs: 51-56, SEQ ID NOs: 58-59, SEQ ID NO: 62, SEQ ID NOs: 64-66, SEQ ID NOs: 68-72 or SEQ ID NOs: 337-338; or (ii) nucleic acid molecules comprising a nucleotide sequence capable of hybridising to a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more of the sequences of (i) under high stringency conditions at 42°C in one or more biological samples from said individual wherein the co-expression of said nucleic acid molecules is indicative of the onset or predisposition to the onset of a colorectal adenoma. a) measuring the level of expression of: (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60; or (ii) a nucleic acid molecule comprising a nucleotide sequence capable of hybridising to SEQ ID NO:60 under high stringency conditions at 42°C in a biological sample from said individual wherein an increase in the level of expression of said nucleic acid molecule relative to the normal level of expression of said nucleic acid molecule in an individual is indicative of the onset or predisposition to the onset of a colorectal adenoma; or (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60; or (ii) a nucleic acid molecule comprising a nucleotide sequence capable of hybridising to SEQ ID NO:60 under high stringency conditions at 42°C b) detecting the co-expression of: (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more nucleic acid molecules comprising a nucleotide sequence as set forth in any one of SEQ ID NOs: 1-2, SEQ ID NOs: 4-6, SEQ ID NOs: 7-32, SEQ ID NOs: 35-37, SEQ ID NO: 38, SEQ ID NOs: 40-43, SEQ ID NOs: 45-49, SEQ ID NOs: 51-56, SEQ ID NOs: 58-59, SEQ ID NO: 62, SEQ ID NOs: 64-66, SEQ ID NOs: 68-72 or SEQ ID NOs: 337-338; or (ii) nucleic acid molecules comprising a nucleotide sequence capable of hybridising to a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more of the sequences of (i) under high stringency conditions at 42°C in one or more biological samples from said individual wherein the co-expression of said nucleic acid molecules is indicative of the onset or predisposition to the onset of a colorectal adenoma. (i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more nucleic acid molecules comprising a nucleotide sequence as set forth in any one of SEQ ID NOs: 1-2, SEQ ID NOs: 4-6, SEQ ID NOs: 7-32, SEQ ID NOs: 35-37, SEQ ID NO: 38, SEQ ID NOs: 40-43, SEQ ID NOs: 45-49, SEQ ID NOs: 51-56, SEQ ID NOs: 58-59, SEQ ID NO: 62, SEQ ID NOs: 64-66, SEQ ID NOs: 68-72 or SEQ ID NOs: 337-338; or (ii) nucleic acid molecules comprising a nucleotide sequence capable of hybridising to a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:60 and any one or more of the sequences of (i) under high stringency conditions at 42°C