Device (1; 100; 200; 300) for the extraction of blood or a blood compound, comprising: - a tube that extends along a longitudinal axis and which has a lateral wall, a closed distal end, a proximal end opposite the distal end and an interior cavity communicated with the exterior by an opening at the proximal end; - a piston assembly (50; 250; 350) that is movable along the interior cavity of the tube, the piston assembly (50; 250; 350) delimiting a space between the piston assembly (50; 250; 350) and the distal end of the tube; - a handle assembly (30; 130; 330), having a gripping portion (32; 132) and an end portion (34; 134; 334); characterised in that the device further comprises - a perforable sealing element (70; 270; 370); wherein - the device (1; 100; 200; 300) is configured to adopt an advancing position in which the handle assembly (30; 130; 230) pushes the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) towards the distal end and is not clipped to the piston assembly (50; 150; 250), and in which air in the space is expelled through the piston assembly (50; 150; 250) and/or via a space between the piston assembly (50; 150; 250) and the lateral wall of the tube; and wherein - the device (1; 100; 200; 300) is configured to adopt a retreating position in which the end portion (34; 134; 334) of the handle assembly (30; 130; 230) is clipped to the piston assembly (50; 150; 250) and pulls the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) towards the proximal end, and in which the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) seal the space. - a tube that extends along a longitudinal axis and which has a lateral wall, a closed distal end, a proximal end opposite the distal end and an interior cavity communicated with the exterior by an opening at the proximal end; - a piston assembly (50; 250; 350) that is movable along the interior cavity of the tube, the piston assembly (50; 250; 350) delimiting a space between the piston assembly (50; 250; 350) and the distal end of the tube; - a handle assembly (30; 130; 330), having a gripping portion (32; 132) and an end portion (34; 134; 334); characterised in that the device further comprises - a perforable sealing element (70; 270; 370); wherein - the device (1; 100; 200; 300) is configured to adopt an advancing position in which the handle assembly (30; 130; 230) pushes the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) towards the distal end and is not clipped to the piston assembly (50; 150; 250), and in which air in the space is expelled through the piston assembly (50; 150; 250) and/or via a space between the piston assembly (50; 150; 250) and the lateral wall of the tube; and wherein - the device (1; 100; 200; 300) is configured to adopt a retreating position in which the end portion (34; 134; 334) of the handle assembly (30; 130; 230) is clipped to the piston assembly (50; 150; 250) and pulls the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) towards the proximal end, and in which the piston assembly (50; 150; 250) and the perforable sealing element (70; 270; 370) seal the space.