A compound of formula I: wherein: D is selected from a direct bond, -O-, -CH 2 O-, -OCH 2 -, -C(=O)NR D -, and - N(R D)C(=O)-; R D is selected from hydrogen and (C 1 -C 6)alkyl; T is a benzene ring or a five- or six-membered heteroaromatic ring; U is a benzene ring or a five- or six-membered heteroaromatic ring; X 1, X 2, X 3, and X 4 are independently selected in each instance from hydrogen, halogen, nitro, cyano, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)haloalkoxy, (Ci-C 6)haloalkylthio, -NR 1 R 2, -OR 1, -C R 1, -OC R 1, -C NR 1 R 2, -C OR 1, -SR 1, - SO 2 R 1, and -SO 2 NR 1 R 2; R 1 and R 2 are independently selected in each instance from the group consisting of hydrogen and (C 1 -C 6)alkyl; Q is selected from -O-, S n -, and -NR-; n is zero, 1 or 2; R is selected from hydrogen, optionally substituted (C 1 -C 6)alkyl, (C 3 -C 7)cycloalkyl, aryl, or heteroaryl; -SO 2 R 3; -SO 2 N(R 3 R 4); -C(=O)R 5; -C(=O)OR 5; or -C(=O)N(R 3 R 4); wherein said substituents on the (C 1 -C 6)alkyl, (C 3 -C 7)cycloalkyl, aryl, or heteroaryl are selected from the group consisting of hydroxy, halogen, cyano, nitro, amino, (C 1 -C 4)alkylamino, (C 1 -C 4)dialkylamino, (C 1 -C 4)acylamino, (C 1 -C 4)alkylsulfonyl, (Ci-C 4)alkylthio, (C 1 -C 4)alkyl, (C 3 -C 7)cycloalkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)haloalkoxy, and (C 1 -C 4)alkoxy; R 3 and R 4 are independently selected in each instance from hydrogen, (C 1 -C 6)alkyl, aryl, and arylalkyl, wherein said aryl or the aryl of the arylalkyl is optionally substituted with hydroxy, halogen, cyano, nitro, amino, (C 1 -C 4)alkylamino, (C 1 -C 4)dialkylamino, (Ci-C 4)acylamino, (C 1 -C 4)alkylsulfonyl, (C 1 -C 4)alkylthio, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (Ci-C 4)haloalkoxy, and (C 1 -C 4)alkoxy; R 5 is selected from hydrogen, optionally substituted (C 1 -C 4)alkyl, or optionally substituted aryl, wherein said optional substituents are selected from the group consisting of (C 1 -C 3)alkyl, OR 1, NH 2, NHMe, N(Me) 2, and heterocycle; Y is selected from hydrogen or hydroxyl; V is selected from phenyl, a six-membered heteroaromatic ring, furan, and thiophene; Z 1 and Z 2 are independently selected in each instance from the group consisting of hydrogen, halogen, nitro, cyano, azide, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)haloalkoxy, - (C 1 -C 6)haloalkylthio, -NR 1 R 2, -NR 1 C R 2, -NR 1 C OR 6, -OR 1, -C R 1, -OC R 1, - C NR 1 R 2, -C OR 1, -SR 1, -SO 2 R 1, and -SO 2 NR 1 R 2; and R 6 is (C 1 -C 8)hydrocarbon. D is selected from a direct bond, -O-, -CH 2 O-, -OCH 2 -, -C(=O)NR D -, and - N(R D)C(=O)-; R D is selected from hydrogen and (C 1 -C 6)alkyl; T is a benzene ring or a five- or six-membered heteroaromatic ring; U is a benzene ring or a five- or six-membered heteroaromatic ring; X 1, X 2, X 3, and X 4 are independently selected in each instance from hydrogen, halogen, nitro, cyano, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)haloalkoxy, (Ci-C 6)haloalkylthio, -NR 1 R 2, -OR 1, -C R 1, -OC R 1, -C NR 1 R 2, -C OR 1, -SR 1, - SO 2 R 1, and -SO 2 NR 1 R 2; R 1 and R 2 are independently selected in each instance from the group consisting of hydrogen and (C 1 -C 6)alkyl; Q is selected from -O-, S n -, and -NR-; n is zero, 1 or 2; R is selected from hydrogen, optionally substituted (C 1 -C 6)alkyl, (C 3 -C 7)cycloalkyl, aryl, or heteroaryl; -SO 2 R 3; -SO 2 N(R 3 R 4); -C(=O)R 5; -C(=O)OR 5; or -C(=O)N(R 3 R 4); wherein said substituents on the (C 1 -C 6)alkyl, (C 3 -C 7)cycloalkyl, aryl, or heteroaryl are selected from the group consisting of hydroxy, halogen, cyano, nitro, amino, (C 1 -C 4)alkylamino, (C 1 -C 4)dialkylamino, (C 1 -C 4)acylamino, (C 1 -C 4)alkylsulfonyl, (Ci-C 4)alkylthio, (C 1 -C 4)alkyl, (C 3 -C 7)cycloalkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)haloalkoxy, and (C 1 -C 4)alkoxy; R 3 and R 4 are independently selected in each instance from hydrogen, (C 1 -C 6)alkyl, aryl, and arylalkyl, wherein said aryl or the aryl of the arylalkyl is optionally substituted with hydroxy, halogen, cyano, nitro, amino, (C 1 -C 4)alkylamino, (C 1 -C 4)dialkylamino, (Ci-C 4)acylamino, (C 1 -C 4)alkylsulfonyl, (C 1 -C 4)alkylthio, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (Ci-C 4)haloalkoxy, and (C 1 -C 4)alkoxy; R 5 is selected from hydrogen, optionally substituted (C 1 -C 4)alkyl, or optionally substituted aryl, wherein said optional substituents are selected from the group consisting of (C 1 -C 3)alkyl, OR 1, NH 2, NHMe, N(Me) 2, and heterocycle; Y is selected from hydrogen or hydroxyl; V is selected from phenyl, a six-membered heteroaromatic ring, furan, and thiophene; Z 1 and Z 2 are independently selected in each instance from the group consisting of hydrogen, halogen, nitro, cyano, azide, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)haloalkoxy, - (C 1 -C 6)haloalkylthio, -NR 1 R 2, -NR 1 C R 2, -NR 1 C OR 6, -OR 1, -C R 1, -OC R 1, - C NR 1 R 2, -C OR 1, -SR 1, -SO 2 R 1, and -SO 2 NR 1 R 2; and R 6 is (C 1 -C 8)hydrocarbon.