mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising an induced mammalian pluripotent stem cell (iPSC) and a cell culture medium, wherein: (a) the cell culture medium comprises: (i) a small molecule that promotes glycolytic metabolism or a histone deacetylase (HDAC) inhibitor, wherein the small molecule that promotes glycolytic metabolism is selected from the group consisting of F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), and PDK1 activator (3'-phosphoinositide-dependent kinase-1), and (ii) a TGFβ receptor/ALK5 inhibitor and a MEK inhibitor; and (b) the iPSC is reprogrammed from a non-pluripotent mammalian cell that (i) comprises an exogenous polynucleotide encoding an Oct4 polypeptide and an exogenous polynucleotide encoding a Klf polypeptide, and (ii) is in contact with the small molecule or HDAC inhibitor, wherein contacting the non-pluripotent mammalian cell with the small molecule or HDAC inhibitor enhances reprogramming when compared to without the small molecule or HDAC inhibitor. (a) the cell culture medium comprises: (i) a small molecule that promotes glycolytic metabolism or a histone deacetylase (HDAC) inhibitor, wherein the small molecule that promotes glycolytic metabolism is selected from the group consisting of F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), and PDK1 activator (3'-phosphoinositide-dependent kinase-1), and (ii) a TGFβ receptor/ALK5 inhibitor and a MEK inhibitor; and (i) a small molecule that promotes glycolytic metabolism or a histone deacetylase (HDAC) inhibitor, wherein the small molecule that promotes glycolytic metabolism is selected from the group consisting of F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), and PDK1 activator (3'-phosphoinositide-dependent kinase-1), and (ii) a TGFβ receptor/ALK5 inhibitor and a MEK inhibitor; and (b) the iPSC is reprogrammed from a non-pluripotent mammalian cell that (i) comprises an exogenous polynucleotide encoding an Oct4 polypeptide and an exogenous polynucleotide encoding a Klf polypeptide, and (ii) is in contact with the small molecule or HDAC inhibitor, wherein contacting the non-pluripotent mammalian cell with the small molecule or HDAC inhibitor enhances reprogramming when compared to without the small molecule or HDAC inhibitor.
A segmented component (12; 14) for a gas turbine engine, the component comprising: a gas path portion (12B; 14B) for interacting with gas flow of the gas turbine engine; wherein the component is divided into axially stacked and abutting segments comprising: a forward segment (24A; 26A); an aft segment (24B; 26B); and a plurality of middle segments (24C; 26C) disposed between the forward segment and the aft segment, the plurality of middle segments comprising radially elongate ceramic matrix composite material plates; and characterised in that each segment further comprises a root portion (12A; 14A) extending radially inwardly from the gas path portion, the root portion having a geometry for providing radial retention with a rotor of the gas turbine engine. a gas path portion (12B; 14B) for interacting with gas flow of the gas turbine engine; wherein the component is divided into axially stacked and abutting segments comprising: a forward segment (24A; 26A); an aft segment (24B; 26B); and a plurality of middle segments (24C; 26C) disposed between the forward segment and the aft segment, the plurality of middle segments comprising radially elongate ceramic matrix composite material plates; and characterised in that a forward segment (24A; 26A); an aft segment (24B; 26B); and a plurality of middle segments (24C; 26C) disposed between the forward segment and the aft segment, the plurality of middle segments comprising radially elongate ceramic matrix composite material plates; and characterised in that each segment further comprises a root portion (12A; 14A) extending radially inwardly from the gas path portion, the root portion having a geometry for providing radial retention with a rotor of the gas turbine engine.
Edge emitting semiconductor laser comprising: - an active, radiation-generating zone, and - a common waveguide, which is suitable for guiding the radiation generated in the active zone within the semiconductor laser, wherein - the common waveguide comprises a first n-doped layer and a second n-doped layer, wherein the second n-doped layer is arranged between the first n-doped layer and the active zone and the fundamental mode of the laser radiation is substantially limited to the second n-doped layer, - the refractive index n 2 of the second n-doped layer is greater than the refractive index n 1 of the first n-doped layer by a value dn, characterized in that the common waveguide is free of a p-doped layer, or the common waveguide has a single p-doped layer, the thickness of which is not greater than 10% of the thickness of the common waveguide.. - an active, radiation-generating zone, and - a common waveguide, which is suitable for guiding the radiation generated in the active zone within the semiconductor laser, wherein - the common waveguide comprises a first n-doped layer and a second n-doped layer, wherein the second n-doped layer is arranged between the first n-doped layer and the active zone and the fundamental mode of the laser radiation is substantially limited to the second n-doped layer, - the refractive index n 2 of the second n-doped layer is greater than the refractive index n 1 of the first n-doped layer by a value dn,
Method for controlling a rotational speed (n) of a load machine on a test bench, the load machine being connected to a test object via a shaft, wherein a rotational speed reference variable (n lead) for a controller is generated from a rotational speed setpoint value (n set), characterized in that an adapted rotational speed setpoint value (n adapt) is determined taking into consideration a rotation angle actual value (φ act) and a rotation angle setpoint value (φ set), the rotation angle setpoint value (φ set) being determined as an integrated value from the rotational speed setpoint value (n set), wherein the rotational speed reference variable (n lead) is switched between the rotational speed setpoint value (n set) and the adapted rotational speed setpoint value (n adapt) as a function of the rotational speed.
A head-mounted device, comprising: a head-mounted housing; left and right guide rods coupled to the head-mounted housing, wherein the left and right guide rods are angled at a non-zero angle with respect to each other; and left and right optical modules respectively slidably coupled to the left and right guide rods, wherein the left and right optical modules provide images to respective eye boxes. a head-mounted housing; left and right guide rods coupled to the head-mounted housing, wherein the left and right guide rods are angled at a non-zero angle with respect to each other; and left and right optical modules respectively slidably coupled to the left and right guide rods, wherein the left and right optical modules provide images to respective eye boxes.
A stirring apparatus, comprising: a stirring unit executing a stirring process on cells which adhere to an inner surface of a culture vessel to be cultured; and a control unit (1 3), wherein the control unit: calculates adhesive strength between the cells and the inner surface of the culture vessel and calculates adhesive strength between the mutual cells; calculates a magnitude relation between the calculated adhesive strength between the cells and the inner surface of the culture vessel and the calculated adhesive strength between the mutual cells; determines a process content of the stirring process in the stirring unit based on the calculated magnitude relation; and drive-controls the stirring unit based on the determined process content of the stirring process. a stirring unit executing a stirring process on cells which adhere to an inner surface of a culture vessel to be cultured; and a control unit (1 3), wherein the control unit: calculates adhesive strength between the cells and the inner surface of the culture vessel and calculates adhesive strength between the mutual cells; calculates a magnitude relation between the calculated adhesive strength between the cells and the inner surface of the culture vessel and the calculated adhesive strength between the mutual cells; determines a process content of the stirring process in the stirring unit based on the calculated magnitude relation; and drive-controls the stirring unit based on the determined process content of the stirring process. calculates adhesive strength between the cells and the inner surface of the culture vessel and calculates adhesive strength between the mutual cells; calculates a magnitude relation between the calculated adhesive strength between the cells and the inner surface of the culture vessel and the calculated adhesive strength between the mutual cells; determines a process content of the stirring process in the stirring unit based on the calculated magnitude relation; and drive-controls the stirring unit based on the determined process content of the stirring process.
An electrical contactor comprising: a fixed contact having a center leg extending along a longitudinal axis between a first end and a second end, wherein the second end of the fixed contact includes a first arm and a second arm each extending in opposite directions from the center leg; a movable contact having a first blade and a second blade, wherein the movable contact is positioned such that the first blade is located between the first arm and the center leg of the fixed contact and the second blade is located between the second arm and the center leg of the fixed contact; and an actuating arrangement positioned to engage both the first and second blades of the movable contact, wherein the actuating arrangement is movable between a closed position in which the actuating arrangement forces the first blade into contact with the first arm and simultaneously forces the second blade into contact with the second arm and an open position in which the actuating arrangement forces the separation of the first blade and the first arm and forces the separation between the second blade and the second arm. a fixed contact having a center leg extending along a longitudinal axis between a first end and a second end, wherein the second end of the fixed contact includes a first arm and a second arm each extending in opposite directions from the center leg; a movable contact having a first blade and a second blade, wherein the movable contact is positioned such that the first blade is located between the first arm and the center leg of the fixed contact and the second blade is located between the second arm and the center leg of the fixed contact; and an actuating arrangement positioned to engage both the first and second blades of the movable contact, wherein the actuating arrangement is movable between a closed position in which the actuating arrangement forces the first blade into contact with the first arm and simultaneously forces the second blade into contact with the second arm and an open position in which the actuating arrangement forces the separation of the first blade and the first arm and forces the separation between the second blade and the second arm.
A tube feed formulation comprising: at least five different whole food components; a source of vitamins or minerals; a source of protein; a source of carbohydrate; a source of fat; and at least one of an herb, a spice and a flavoring, wherein the tube feed formulation has an osmolality that is less than or equal to 400 mOsm/kg water. at least five different whole food components; a source of vitamins or minerals; a source of protein; a source of carbohydrate; a source of fat; and at least one of an herb, a spice and a flavoring, wherein the tube feed formulation has an osmolality that is less than or equal to 400 mOsm/kg water.
A method for condensing a vaporous material comprising: providing a gas stream comprising the vapour, passing the gas stream through a nozzle which has an upstream converging configuration and a downstream diverging configuration so that the vapour accelerates into the nozzle and expands and cools on exiting the nozzle thereby inducing the vapour to condense to form a beam of liquid droplets or solid particles in the condensing chamber, wherein the beam of droplets or particles is directed to impinge onto a bath of molten liquid collection medium maintained at a temperature above the melting point of the condensed vaporous material and characterised in that the molten collection medium comprises a salt flux which has a specific gravity lower than that of the condensed vaporous material. providing a gas stream comprising the vapour, passing the gas stream through a nozzle which has an upstream converging configuration and a downstream diverging configuration so that the vapour accelerates into the nozzle and expands and cools on exiting the nozzle thereby inducing the vapour to condense to form a beam of liquid droplets or solid particles in the condensing chamber, wherein the beam of droplets or particles is directed to impinge onto a bath of molten liquid collection medium maintained at a temperature above the melting point of the condensed vaporous material and characterised in that the molten collection medium comprises a salt flux which has a specific gravity lower than that of the condensed vaporous material.
A crosslinkable polymeric composition having a number average molecular weight between 5,000 and 40,000 (according to DIN St 55672) derived from A, B, C, D, E and F monomers wherein: A is 15 to 95% by weight of the total monomers having the formula: wherein R1, R2, R3 are hydrogen or alkyl groups with 1 to 15 carbon atoms, the total number of Carbon atoms of R1,R2 and R3 ranging from 1 to 20 and B is 5 to 35% by weight of the total monomers of a vinyl silane having the formula: wherein R4, R5 and R6 are alkyl or alkyloxy groups having 1 to 4 carbon atoms, C is 0 to 40% by weight of vinyl acetate D is 0 to 40% weight of a acrylate/or metacrylate ester E is 0 to 25% weight of a acrylosilane monomer. F is 0 to 25% weight of any other vinyl monomer A is 15 to 95% by weight of the total monomers having the formula: wherein R1, R2, R3 are hydrogen or alkyl groups with 1 to 15 carbon atoms, the total number of Carbon atoms of R1,R2 and R3 ranging from 1 to 20 and B is 5 to 35% by weight of the total monomers of a vinyl silane having the formula: wherein R4, R5 and R6 are alkyl or alkyloxy groups having 1 to 4 carbon atoms, C is 0 to 40% by weight of vinyl acetate D is 0 to 40% weight of a acrylate/or metacrylate ester E is 0 to 25% weight of a acrylosilane monomer. F is 0 to 25% weight of any other vinyl monomer
A preform for a composite part, the preform comprising: dry fibers, and catalyst capsules interspersed among the dry fibers, each catalyst capsule comprising a shell and a catalyst encapsulated within the shell, which catalyst accelerates polymerization of resin monomers usable in curing the preform, wherein one or more of the fibers are configured to attract and/or attach the interspersed catalyst capsules to the surface of the fibers. dry fibers, and catalyst capsules interspersed among the dry fibers, each catalyst capsule comprising a shell and a catalyst encapsulated within the shell, which catalyst accelerates polymerization of resin monomers usable in curing the preform, wherein one or more of the fibers are configured to attract and/or attach the interspersed catalyst capsules to the surface of the fibers.
Valve having a housing which comprises three valve chambers which are situated one behind the other, wherein two valve chambers are connected to one another by way of an opening which has a valve seat, having a plunger, having two bearing points for the plunger, and having two closing bodies which are arranged on the plunger, wherein each closing body interacts with a valve seat, characterized in that the plunger is connected to an additional component, which has a receiving part for the plunger and has at least two arms which extend radially outwards from the receiving part, wherein the free ends of the arms are fixedly connected to a component which is fixedly connected to the housing, wherein each arm has a flexible region which is formed such that the receiving part follows the movement of the plunger, and wherein the additional component is arranged on the plunger between the two closing bodies, and the two valve seats are formed by the component, which is fixedly connected to the housing.
An anti-fungal agent for a processed cereal food, comprising chitinase and calcium propionate, wherein the calcium propionate is contained in a ratio of 0.1 to 500 parts by mass to 1 part by mass of the chitinase.
A method for steam ironing men's socks, according to which the socks are loaded onto respective support forms each fastened to a respective shuttle movable in a step manner, along branches (I, II, III, IV) of a quadrangular path comprising a sock-boarding zone, a steam ironing station, a drying station and a station for removing the socks from the support forms, and wherein the shuttles are sequentially moved along said quadrangular path, transferring the shuttles from one branch to another (I, II, III, IV) at the corners (A, B, C, D) of the quadrangular path, characterised by: providing a plurality of pairs of independent shuttles (13A, 13B), each pair of shuttles (13A, 13B) comprising first and second sock support forms (14A, 14B) for a pair of socks, longitudinally oriented to the moving direction of the same forms; opening the shuttles of each pair (13A, 13B) to space apart the support forms (14A, 14B) for the socks, at the boarding zone; closing the shuttles (14A, 14B) of each pair of shuttles in contact with one another and positioning side by side the support forms (14A, 14B) for each pair of socks to be ironed; moving sequentially each pair of shuttles (13A, 13B) with the sock support forms (14A, 14B) side by side arranged, through the ironing station, along the drying station and through the removal station for the socks; selectively rotating single pairs of shuttles (13A, 13B) at the corners (A, B, C, D) of the quadrangular path, to transfer pairs of shuttles (13A, 13B) from one branch to the next one of the quadrangular path, while maintaining the shuttles (13A, 13B) of each pair of shuttles in a closed condition with the sock support forms (14A, 14B); and simultaneously removing each pair of socks from the support forms (14A, 14B), at said removal station. providing a plurality of pairs of independent shuttles (13A, 13B), each pair of shuttles (13A, 13B) comprising first and second sock support forms (14A, 14B) for a pair of socks, longitudinally oriented to the moving direction of the same forms; opening the shuttles of each pair (13A, 13B) to space apart the support forms (14A, 14B) for the socks, at the boarding zone; closing the shuttles (14A, 14B) of each pair of shuttles in contact with one another and positioning side by side the support forms (14A, 14B) for each pair of socks to be ironed; moving sequentially each pair of shuttles (13A, 13B) with the sock support forms (14A, 14B) side by side arranged, through the ironing station, along the drying station and through the removal station for the socks; selectively rotating single pairs of shuttles (13A, 13B) at the corners (A, B, C, D) of the quadrangular path, to transfer pairs of shuttles (13A, 13B) from one branch to the next one of the quadrangular path, while maintaining the shuttles (13A, 13B) of each pair of shuttles in a closed condition with the sock support forms (14A, 14B); and simultaneously removing each pair of socks from the support forms (14A, 14B), at said removal station.
Fluid line for conducting a fluid, comprising: an outer layer, which comprises an acrylate elastomer; an intermediate layer, which comprises an acrylate elastomer, and which is arranged within the outer layer, and a barrier layer, which comprises a fluoroelastomer, which barrier layer is arranged within the intermediate layer and which delimits a line interior of the fluid line for conducting the fluid, wherein the barrier layer is configured to reduce a diffusion of the fluid through the barrier layer, wherein the outer layer and/or intermediate layer comprises an aminic and/or peroxide cross-linked acrylate elastomer, and/or wherein the acrylate elastomer comprises ethylene-acrylate rubber and/or polyacrylate rubber. an outer layer, which comprises an acrylate elastomer; an intermediate layer, which comprises an acrylate elastomer, and which is arranged within the outer layer, and a barrier layer, which comprises a fluoroelastomer, which barrier layer is arranged within the intermediate layer and which delimits a line interior of the fluid line for conducting the fluid, wherein the barrier layer is configured to reduce a diffusion of the fluid through the barrier layer, wherein the outer layer and/or intermediate layer comprises an aminic and/or peroxide cross-linked acrylate elastomer, and/or wherein the acrylate elastomer comprises ethylene-acrylate rubber and/or polyacrylate rubber.
An applicator for applying a microneedle device, comprising: a housing having a first open end configured so as to accept the microneedle device, a second end configured as a graspable handle, a driving element contained within the housing, the driving element having a first end configured so as to couple with the microneedle device, a microneedle device, an actuation button in mechanical or electrical engagement with the driving element, a device life indicator in mechanical or electrical engagement with at least one of the driving element or the actuation button, wherein the device life indicator is capable of counting the number of use cycles that the applicator has undergone and, based on the number of use cycles, providing feedback to the user as to the use status of the applicator. a housing having a first open end configured so as to accept the microneedle device, a second end configured as a graspable handle, a driving element contained within the housing, the driving element having a first end configured so as to couple with the microneedle device, a microneedle device, an actuation button in mechanical or electrical engagement with the driving element, a device life indicator in mechanical or electrical engagement with at least one of the driving element or the actuation button, wherein the device life indicator is capable of counting the number of use cycles that the applicator has undergone and, based on the number of use cycles, providing feedback to the user as to the use status of the applicator.