A recombinant herpesvirus comprising a heterologous polypeptide ligand capable of binding to a target molecule, a wherein the heterologous polypeptide ligand is inserted into glycoprotein B (gB) present in the envelope of the herpesvirus, b) wherein the herpesvirus has the capability of binding to a cell expressing or binding the target molecule via the heterologous polypeptide ligand, c) wherein the herpesvirus has the capability of entering the cell via the heterologous polypeptide ligand, d) wherein the heterologous polypeptide ligand is a part of the GCN4 yeast transcription factor such as the epitope of the GCN4 yeast transcription factor as comprised by SEQ ID NO: 37, and e) wherein the ligand is characterized as follows: e1) either wherein the ligand is inserted at any amino acid within a disordered region of gB, but is not inserted at any amino acid within the region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e2) either wherein the ligand is inserted at any amino acid within a region spanning from amino acids 31 to 77 or 88 to 184, preferably amino acids 31 to 77 or 88 to 136 or more preferably 31 to 77 or 88 to 108, and/or within a region spanning from amino acids 409 to 545, preferably amino acids 459 to 545, more preferably amino acids 459 to 497, or still more preferably amino acids 460 to 491, of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e3) either wherein the ligand has a length of 5 to 120 amino acids and is inserted at any amino acid within a region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB. a wherein the heterologous polypeptide ligand is inserted into glycoprotein B (gB) present in the envelope of the herpesvirus, b) wherein the herpesvirus has the capability of binding to a cell expressing or binding the target molecule via the heterologous polypeptide ligand, c) wherein the herpesvirus has the capability of entering the cell via the heterologous polypeptide ligand, d) wherein the heterologous polypeptide ligand is a part of the GCN4 yeast transcription factor such as the epitope of the GCN4 yeast transcription factor as comprised by SEQ ID NO: 37, and e) wherein the ligand is characterized as follows: e1) either wherein the ligand is inserted at any amino acid within a disordered region of gB, but is not inserted at any amino acid within the region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e2) either wherein the ligand is inserted at any amino acid within a region spanning from amino acids 31 to 77 or 88 to 184, preferably amino acids 31 to 77 or 88 to 136 or more preferably 31 to 77 or 88 to 108, and/or within a region spanning from amino acids 409 to 545, preferably amino acids 459 to 545, more preferably amino acids 459 to 497, or still more preferably amino acids 460 to 491, of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e3) either wherein the ligand has a length of 5 to 120 amino acids and is inserted at any amino acid within a region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB. e1) either wherein the ligand is inserted at any amino acid within a disordered region of gB, but is not inserted at any amino acid within the region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e2) either wherein the ligand is inserted at any amino acid within a region spanning from amino acids 31 to 77 or 88 to 184, preferably amino acids 31 to 77 or 88 to 136 or more preferably 31 to 77 or 88 to 108, and/or within a region spanning from amino acids 409 to 545, preferably amino acids 459 to 545, more preferably amino acids 459 to 497, or still more preferably amino acids 460 to 491, of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB, or e3) either wherein the ligand has a length of 5 to 120 amino acids and is inserted at any amino acid within a region spanning from amino acids 77 to 88 of gB according to SEQ ID NO: 1 or within a corresponding region of a homologous gB.