A compound of Formula wherein: R 1 is pyridyl, pyridyl- N -oxide, 1 H -pyridin-2-onyl, indolyl, pyrazinyl, 3- H -thiazol-2-onyl, pyrimidyl, benzooxazolyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, thiophenyl, furyl, [1,2,4]oxadiazolyl or [1,3,4]thiadiazolyl; wherein said pyridyl, pyridyl- N -oxide, pyrimidyl, pyrazolyl, imidazolyl, thiophenyl, or thiazolyl is optionally substituted with one substituent selected from the group consisting of OC alkyl, OC cycloalkyl, OCH 2 CF 3, OCH 2 Ph, F, CN, CH 2 CN, C alkyl, CH 2 CF 3, N(C alkyl) 2, C alkylOH, Si(CH 3) 3, -C≡CH, SCH 3, S CH 3, SO 2 CH 3, pyrrolidinyl, OH, NH 2, NHCN, CO 2 H, CONH 2, NHCO 2 C alkyl, N(SO 2 CH 3) 2, NHSO 2 CH 3, NHC CF 3, NHC alkyl, NHCO 2 H, NHCO 2 C alkyl, NHCOC alkyl, NHCONH 2, NHCONHC alkyl, and Br; or said pyridyl may be substituted with one OCH 3 group and one CH 3; or wherein said pyrimidyl is optionally substituted with one N(C alkyl) 2 group or one or two OCH 3 groups; or wherein said thiazolyl is optionally substituted on two adjacent carbon atoms to form fused bicyclic system benzothiazol-2-yl, or wherein said benzothiazol-2-yl is optionally substituted with Br or OCH 3; or wherein said 1 H- pyridin-2-onyl is optionally substituted with one substituent selected from the group consisting of CH 2 CN, C alkyl, CH 2 CF 3, and CH 2 CH 2 OH, or said 1 H -pyridin-2-onyl may be optionally substituted with up to 2 methyl groups; or wherein said [1,2,4]oxadiazolyl is optionally substituted on any carbon atom with CCl 3, or pyrrolidinyl, or alternatively both hydrogens on said carbon atom of said [1,2,4]oxadiazolyl may be replaced by an oxo group; R 2 is C alkyl, NH 2, NO 2, NHCH 2 CH 2 OH, N(C alkyl) 2, N(SO 2 CH 3) 2, CN, F, Cl, Br, CF 3, C cycloalkyl, heterocyclyl, OCF 3, OCF 2 H, CF 2 H, or OC alkyl; R 3 is H, F, Cl, CF 3, or OC alkyl; alternatively, R 2 and R 3 may be taken together with their attached phenyl to form a benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, or 2,3-dihydro-benzo[1,4]dioxinyl group; R 4 is H, OC alkyl, or F; or and solvates, hydrates, tautomers, and pharmaceutically acceptable salts thereof. R 1 is pyridyl, pyridyl- N -oxide, 1 H -pyridin-2-onyl, indolyl, pyrazinyl, 3- H -thiazol-2-onyl, pyrimidyl, benzooxazolyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, thiophenyl, furyl, [1,2,4]oxadiazolyl or [1,3,4]thiadiazolyl; wherein said pyridyl, pyridyl- N -oxide, pyrimidyl, pyrazolyl, imidazolyl, thiophenyl, or thiazolyl is optionally substituted with one substituent selected from the group consisting of OC alkyl, OC cycloalkyl, OCH 2 CF 3, OCH 2 Ph, F, CN, CH 2 CN, C alkyl, CH 2 CF 3, N(C alkyl) 2, C alkylOH, Si(CH 3) 3, -C≡CH, SCH 3, S CH 3, SO 2 CH 3, pyrrolidinyl, OH, NH 2, NHCN, CO 2 H, CONH 2, NHCO 2 C alkyl, N(SO 2 CH 3) 2, NHSO 2 CH 3, NHC CF 3, NHC alkyl, NHCO 2 H, NHCO 2 C alkyl, NHCOC alkyl, NHCONH 2, NHCONHC alkyl, and Br; or said pyridyl may be substituted with one OCH 3 group and one CH 3; or wherein said pyrimidyl is optionally substituted with one N(C alkyl) 2 group or one or two OCH 3 groups; or wherein said thiazolyl is optionally substituted on two adjacent carbon atoms to form fused bicyclic system benzothiazol-2-yl, or wherein said benzothiazol-2-yl is optionally substituted with Br or OCH 3; or wherein said 1 H- pyridin-2-onyl is optionally substituted with one substituent selected from the group consisting of CH 2 CN, C alkyl, CH 2 CF 3, and CH 2 CH 2 OH, or said 1 H -pyridin-2-onyl may be optionally substituted with up to 2 methyl groups; or wherein said [1,2,4]oxadiazolyl is optionally substituted on any carbon atom with CCl 3, or pyrrolidinyl, or alternatively both hydrogens on said carbon atom of said [1,2,4]oxadiazolyl may be replaced by an oxo group; R 2 is C alkyl, NH 2, NO 2, NHCH 2 CH 2 OH, N(C alkyl) 2, N(SO 2 CH 3) 2, CN, F, Cl, Br, CF 3, C cycloalkyl, heterocyclyl, OCF 3, OCF 2 H, CF 2 H, or OC alkyl; R 3 is H, F, Cl, CF 3, or OC alkyl; alternatively, R 2 and R 3 may be taken together with their attached phenyl to form a benzo[1,3]dioxolyl, 2,3-dihydro-benzofuranyl, or 2,3-dihydro-benzo[1,4]dioxinyl group; R 4 is H, OC alkyl, or F; or