mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing a prostaglandin or prostaglandin analog, the method comprising: providing a compound of Formula: wherein: n and m are independently integers between 0 and 10; R 1 is H or a hydroxyl protecting group; R 2 is H, alkyl or aralkyl, wherein the alkyl or aralkyl group optionally comprises one or more substituents; R 3 and R 4 are independently H, alkyl, aralkyl, or aryl, wherein the alkyl, aralkyl, or aryl optionally comprises one or more substituents; reacting the compound of Formula with a catalyst to perform a ring closing metathesis reaction, thereby forming a lactone; and reacting the lactone with a nucleophile, wherein the nucleophile is selected from the group consisting of water, hydroxide, an alcohol, an alkoxide, an aryloxide, a thiol, a thiolate, an amine, an imide, and a sulfonamide, or a salt thereof, thereby forming a compound comprising a hydroxyl group and a carboxylic acid or derivative thereof. providing a compound of Formula: wherein: n and m are independently integers between 0 and 10; R 1 is H or a hydroxyl protecting group; R 2 is H, alkyl or aralkyl, wherein the alkyl or aralkyl group optionally comprises one or more substituents; R 3 and R 4 are independently H, alkyl, aralkyl, or aryl, wherein the alkyl, aralkyl, or aryl optionally comprises one or more substituents; n and m are independently integers between 0 and 10; R 1 is H or a hydroxyl protecting group; R 2 is H, alkyl or aralkyl, wherein the alkyl or aralkyl group optionally comprises one or more substituents; R 3 and R 4 are independently H, alkyl, aralkyl, or aryl, wherein the alkyl, aralkyl, or aryl optionally comprises one or more substituents; reacting the compound of Formula with a catalyst to perform a ring closing metathesis reaction, thereby forming a lactone; and reacting the lactone with a nucleophile, wherein the nucleophile is selected from the group consisting of water, hydroxide, an alcohol, an alkoxide, an aryloxide, a thiol, a thiolate, an amine, an imide, and a sulfonamide, or a salt thereof, thereby forming a compound comprising a hydroxyl group and a carboxylic acid or derivative thereof.
A method for producing pancreatic endocrine cells, the method comprising introducing any one of the following (i) to (iii) into somatic cells: (i) a GLIS1 gene or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof, (ii) a GLIS1 gene or one or more gene products thereof, a Neurogenin3 gene or one or more gene products thereof, and a Pdx1 gene or one or more gene products thereof, and (iii) a GLIS3 gene or one or more gene products thereof, a Neurogenin3 gene or one or more gene products thereof, and a Pdx1 gene or one or more gene products thereof. (i) a GLIS1 gene or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof, (ii) a GLIS1 gene or one or more gene products thereof, a Neurogenin3 gene or one or more gene products thereof, and a Pdx1 gene or one or more gene products thereof, and (iii) a GLIS3 gene or one or more gene products thereof, a Neurogenin3 gene or one or more gene products thereof, and a Pdx1 gene or one or more gene products thereof.
A propellant comprising: an energetic material in the form of granules; and a compound of formula 1 wherein R 1 is selected from the group consisting of -H, -C 1-4 alkyl, -OC 1-4 alkyl, -NH 2, - NHC 1-4 alkyl and -N(C 1-4 alkyl) 2; and R 2 is selected from the group consisting of -H, -C 2-4 alkyl and -C(=O)C 1-4- alkyl, wherein the compound is in the form of a coating on the granules of energetic material that has diffused or penetrated partly or entirely into the granules of energetic material. an energetic material in the form of granules; and a compound of formula 1 wherein R 1 is selected from the group consisting of -H, -C 1-4 alkyl, -OC 1-4 alkyl, -NH 2, - NHC 1-4 alkyl and -N(C 1-4 alkyl) 2; and R 2 is selected from the group consisting of -H, -C 2-4 alkyl and -C(=O)C 1-4- alkyl, wherein the compound is in the form of a coating on the granules of energetic material that has diffused or penetrated partly or entirely into the granules of energetic material. R 1 is selected from the group consisting of -H, -C 1-4 alkyl, -OC 1-4 alkyl, -NH 2, - NHC 1-4 alkyl and -N(C 1-4 alkyl) 2; and R 2 is selected from the group consisting of -H, -C 2-4 alkyl and -C(=O)C 1-4- alkyl, wherein the compound is in the form of a coating on the granules of energetic material that has diffused or penetrated partly or entirely into the granules of energetic material.
A process of preparing a urinary tract soft-tissue bulking agent comprising muscle derived progenitor cells (MDCs), the process comprising: (a) suspending skeletal muscle cells isolated from a human in a first cell culture container for between 30 and 120 minutes; (b) decanting the media from the first cell culture container to a second cell culture container; (c) culturing the cells in the second cell culture container for 1-3 days to allow the remaining cells in the media to attach to the walls of the second cell culture container; (d) isolating the cells from the walls of the second cell culture container, wherein the isolated cells are MDCs. (a) suspending skeletal muscle cells isolated from a human in a first cell culture container for between 30 and 120 minutes; (b) decanting the media from the first cell culture container to a second cell culture container; (c) culturing the cells in the second cell culture container for 1-3 days to allow the remaining cells in the media to attach to the walls of the second cell culture container; (d) isolating the cells from the walls of the second cell culture container, wherein the isolated cells are MDCs.
A furnace coil for a steam cracker comprising one or more sections consisting of: i) a continuous metal passageway permitting the flow of cracked gasses there through having a melting temperature greater than 1000°C adapted to cooperate with passes in the coil; said metal having one or more areas comprising: a) a porosity so that from 10 to 50% of the pores having a size from 0.001 to 0.05 microns; or b) ceramic inserts in or over coating on said metal having a melting point greater than 900°C and a porosity so that from 10 to 50% of pores having a size from 0.001 microns to 0.05 microns; said areas being over coated with a dense gas-selective membrane having a thickness from 0.1 to 10 microns permitting the diffusion of at least one of H 2, CH 4, CO and CO 2 at temperatures from 500°C to 900°C out of said passageway. i) a continuous metal passageway permitting the flow of cracked gasses there through having a melting temperature greater than 1000°C adapted to cooperate with passes in the coil; said metal having one or more areas comprising: a) a porosity so that from 10 to 50% of the pores having a size from 0.001 to 0.05 microns; or b) ceramic inserts in or over coating on said metal having a melting point greater than 900°C and a porosity so that from 10 to 50% of pores having a size from 0.001 microns to 0.05 microns; said areas being over coated with a dense gas-selective membrane having a thickness from 0.1 to 10 microns permitting the diffusion of at least one of H 2, CH 4, CO and CO 2 at temperatures from 500°C to 900°C out of said passageway. a) a porosity so that from 10 to 50% of the pores having a size from 0.001 to 0.05 microns; or b) ceramic inserts in or over coating on said metal having a melting point greater than 900°C and a porosity so that from 10 to 50% of pores having a size from 0.001 microns to 0.05 microns;
Feed-through element for providing an electrically conducting connection through a separating layer, wherein the separating layer is a housing of a battery of a vehicle, having an element body for inserting in a form-fitting or at least substantially form-fitting manner into a feed-through receptacle of the separating layer; the element body having a conductor portion, which is continuously electrically conducting, for providing the electrically conducting connection, and an electrically isolating insulation portion, which circumferentially surrounds the conductor portion at least in portions, for isolating the conductor portion in relation to an internal face of the feed-through receptacle; wherein the element body has a first end face, a second end face lying opposite the first end face, and a shell face connecting the first end face and the second end face, wherein the first end face has a larger cross-sectional area than the second end face, and wherein the shell face is formed in an encircling manner at least in portions by the insulation portion; wherein the feed-through element has a fixing device which for fixing the element body in the feed-through receptacle exerts a fixing force with a fixing direction on the element body, wherein the fixing direction of the fixing force points at least substantially from the first end face towards the second end face, wherein the fixing device has a first spring element for exerting a fixing force pressing onto the first end face, characterized in that the first spring element has at least one first support portion so as to be supported on a first mating support portion on a first surface of the separating layer, and a first introduction portion for introducing the fixing force into a first mating introduction portion on the first end face.
A method comprising: receiving a packet associated with a flow at a network device; classifying the packet at the network device based on information received from a policy layer, including identifying a Network Address Translation, NAT, indicator to insert into the packet based on the flow; inserting the NAT indicator for the flow into the packet; transmitting the packet in a service chain comprising NAT; wherein the NAT indicator is associated with the flow before NAT and the flow after NAT at the policy layer by creating a binding between the flow before NAT and the flow after NAT at the policy layer, to provide symmetry between the service chain and a return service chain, wherein providing symmetry between the service chain and the return service chain provides for traffic returning through the same set of services in the reverse direction as in the forward direction; the method further comprising: receiving a return packet associated with the flow; using the binding created at the policy layer to provide classification information, including the NAT indicator, for the return packet; inserting the NAT indicator into the return packet; and transmitting the return packet in the return service chain. receiving a packet associated with a flow at a network device; classifying the packet at the network device based on information received from a policy layer, including identifying a Network Address Translation, NAT, indicator to insert into the packet based on the flow; inserting the NAT indicator for the flow into the packet; transmitting the packet in a service chain comprising NAT; wherein the NAT indicator is associated with the flow before NAT and the flow after NAT at the policy layer by creating a binding between the flow before NAT and the flow after NAT at the policy layer, to provide symmetry between the service chain and a return service chain, wherein providing symmetry between the service chain and the return service chain provides for traffic returning through the same set of services in the reverse direction as in the forward direction; the method further comprising: receiving a return packet associated with the flow; using the binding created at the policy layer to provide classification information, including the NAT indicator, for the return packet; inserting the NAT indicator into the return packet; and transmitting the return packet in the return service chain. receiving a return packet associated with the flow; using the binding created at the policy layer to provide classification information, including the NAT indicator, for the return packet; inserting the NAT indicator into the return packet; and transmitting the return packet in the return service chain.
Topical compositions for the stimulating of sexual response in females and/or males, and/or in the increasing of the intensity of said response, also up to the maximisation thereof, comprising - at least 0.5% by weight of menthyl nicotinate as primary stimulating active agent acting on the physiology of the female and/or male sexual response; and - at least one suitable lipophilic vehicle suitable for solubilising the menthyl nicotinate and allowing rapid skin absorption thereof; and/or - at least one excipient said compositions being dermatologically acceptable for the topical administering on the epithelial tissues of the female and/or male erogenous zones. - at least 0.5% by weight of menthyl nicotinate as primary stimulating active agent acting on the physiology of the female and/or male sexual response; and - at least one suitable lipophilic vehicle suitable for solubilising the menthyl nicotinate and allowing rapid skin absorption thereof; and/or - at least one excipient
A cleaner comprising: a suction unit guiding air and dust; a main body coupled to the suction unit and comprising a first cyclone unit separating the air and the dust, which are suctioned through the suction unit, from each other and a second cyclone unit separating the dust from the air discharged from the first cyclone unit; and a guide unit disposed in the main body to partition a first dust storage part, in which the dust separated in the first cyclone unit is stored, and a second dust storage part, in which the dust separated in the second cyclone unit is stored, from each other, characterized in that the guide unit is separably coupled to the main body, and when the guide unit is separated from the main body, a dust discharge part of the second cyclone unit is exposed to an outside. a suction unit guiding air and dust; a main body coupled to the suction unit and comprising a first cyclone unit separating the air and the dust, which are suctioned through the suction unit, from each other and a second cyclone unit separating the dust from the air discharged from the first cyclone unit; and a guide unit disposed in the main body to partition a first dust storage part, in which the dust separated in the first cyclone unit is stored, and a second dust storage part, in which the dust separated in the second cyclone unit is stored, from each other, characterized in that the guide unit is separably coupled to the main body, and when the guide unit is separated from the main body, a dust discharge part of the second cyclone unit is exposed to an outside.
Circuit for measuring the oscillation frequency of a resonator of the type including an excitation input for receiving an actuation signal at a frequency close to the resonant frequency of the resonator and a polarization input for receiving a polarization signal comprising an AC component at a polarization frequency f1, the circuit including a phase-locked loop comprising the resonator, a frequency-controlled oscillator, and a phase comparator (CMPH), the measurement circuit being characterized in that the frequency-controlled oscillator produces the polarization frequency f1 and is linked to the polarization input of the resonator for applying this frequency f1 to it, and in that it furthermore comprises a frequency generator supplying a fixed intermediate frequency FI, a mixer for mixing the intermediate frequency and the polarization frequency f1 and for supplying an excitation frequency f0 that is the sum or difference of f1 and FI and for applying this excitation frequency f0 to the excitation input as actuation signal, the phase comparator receiving the intermediate frequency FI from the generator and a filtered output signal coming from the resonator, and supplying a locking signal (Dph) serving to control the frequency f1 of the oscillator in a direction tending to maintain the excitation frequency at the output of the mixer at the value of the resonant frequency of the resonator.
A dual-direction piston-based actuator housing assembly, comprising: - a hollow cylindrical liner extending along a longitudinal axis defining a proximal end opposite a distal end, wherein the liner is configured to accept a movable piston disposed therein; - a housing disposed over the liner also extending along the longitudinal axis from the proximal end to the distal end; - a compression block disposed adjacent to the proximal end of the liner; - an engagement hole formed in the compression block configured to accept a pin for attachment when in use; - a tension strap disposed over the compression block, the tension strap starting from a first end near the proximal end of the liner, extending around the engagement hole and back to a second end near the proximal end of the liner, wherein the first end and second end are opposite one another disposed 180 degrees apart about the longitudinal axis; - an overwind extending at least over the first and second ends (21, 22) of the tension strap, at least partially over the compression block, and at least partially over the proximal end of the housing; and - a tension clip disposed at the distal end of the liner and embedded within the housing, the tension clip having a recess formed on an inside surface of the tension clip, the recess annularly disposed about the longitudinal axis. - a hollow cylindrical liner extending along a longitudinal axis defining a proximal end opposite a distal end, wherein the liner is configured to accept a movable piston disposed therein; - a housing disposed over the liner also extending along the longitudinal axis from the proximal end to the distal end; - a compression block disposed adjacent to the proximal end of the liner; - an engagement hole formed in the compression block configured to accept a pin for attachment when in use; - a tension strap disposed over the compression block, the tension strap starting from a first end near the proximal end of the liner, extending around the engagement hole and back to a second end near the proximal end of the liner, wherein the first end and second end are opposite one another disposed 180 degrees apart about the longitudinal axis; - an overwind extending at least over the first and second ends (21, 22) of the tension strap, at least partially over the compression block, and at least partially over the proximal end of the housing; and - a tension clip disposed at the distal end of the liner and embedded within the housing, the tension clip having a recess formed on an inside surface of the tension clip, the recess annularly disposed about the longitudinal axis.
A pharmaceutical composition comprising: veldoreotide or a pharmaceutically acceptable salt thereof; an excipient selected from hydroxypropyl-β-cyclodextrin (HPBCD) or dextrose; and a polymeric microsphere, comprising poly(lactic-co-glycolic acid) (PLGA), wherein veldoreotide or the pharmaceutically acceptable salt thereof and the excipient are encapsulated in the polymeric microsphere; and wherein the surface area of the polymeric microsphere is from 7 m 2 /g to 12 m 2 /g. veldoreotide or a pharmaceutically acceptable salt thereof; an excipient selected from hydroxypropyl-β-cyclodextrin (HPBCD) or dextrose; and a polymeric microsphere, comprising poly(lactic-co-glycolic acid) (PLGA), wherein veldoreotide or the pharmaceutically acceptable salt thereof and the excipient are encapsulated in the polymeric microsphere; and wherein the surface area of the polymeric microsphere is from 7 m 2 /g to 12 m 2 /g.
An oil separator for separating mist oil contained in target gas, the oil separator comprising: a plurality of separation disks that are rotatable together with a spindle and that are laminated in an axial direction of the spindle; a nozzle that is projected from a part of a peripheral surface of the spindle, the part being located below the separation disks, and that injects oil from an injection hole to rotate the spindle around an axis; a lower case that includes a gas introducing portion and an oil discharge portion, the gas introducing portion being configured to introduce the target gas, the oil discharge portion being configured to discharge oil; an upper case that is mounted to the lower case from above, the upper case and the lower case separating a chamber, the chamber housing the spindle, the separation disks, and the nozzle; and a partition member that partitions the chamber into a lower chamber and an upper chamber, and that forms a communication port around the spindle at a height between the nozzle and the separation disks, the communication port guiding the target gas that is in the lower chamber to the upper chamber, wherein the gas introducing portion is composed of a tubular member (17; 17') which is provided separately from the oil discharge portion, the tubular member including an introduction-inlet end portion and an introduction-outlet end portion, the introduction-inlet end portion being for the target gas and being located outside of the lower case, the introduction-outlet end portion being for the target gas and being located in a proximity of a lower side of the nozzle. a plurality of separation disks that are rotatable together with a spindle and that are laminated in an axial direction of the spindle; a nozzle that is projected from a part of a peripheral surface of the spindle, the part being located below the separation disks, and that injects oil from an injection hole to rotate the spindle around an axis; a lower case that includes a gas introducing portion and an oil discharge portion, the gas introducing portion being configured to introduce the target gas, the oil discharge portion being configured to discharge oil; an upper case that is mounted to the lower case from above, the upper case and the lower case separating a chamber, the chamber housing the spindle, the separation disks, and the nozzle; and a partition member that partitions the chamber into a lower chamber and an upper chamber, and that forms a communication port around the spindle at a height between the nozzle and the separation disks, the communication port guiding the target gas that is in the lower chamber to the upper chamber, wherein the gas introducing portion is composed of a tubular member (17; 17') which is provided separately from the oil discharge portion, the tubular member including an introduction-inlet end portion and an introduction-outlet end portion, the introduction-inlet end portion being for the target gas and being located outside of the lower case, the introduction-outlet end portion being for the target gas and being located in a proximity of a lower side of the nozzle.