A method for operating a laboratory automation system, having: - a plurality of laboratory devices configured to apply at least one of pre-analytics, analytics, and post-analytics for a sample received in a sample container; - a transport system, comprising - a plurality of carriers each configured to carry one or more sample containers on an automation track to at least one of the plurality of laboratory devices; - a plurality of transport system interfaces; and - a first empty carrier queue provided with a first fixed number of queue spaces which each can be assigned an empty carrier; and - a control device configured to control operation of the transport system; the method comprising: - providing a plurality of additional queue spaces in the transport system, the additional queue spaces each assignable an empty carrier; - assigning a first number of additional queue spaces from the plurality of additional queue spaces to the first empty carrier queue by the control device; - operating the first empty carrier queue with the first fixed number of queue spaces plus the first number of additional queue spaces during runtime of the transport system; characterized in that the method comprises further: - receiving operation data in the control device, the operation data being indicative of a first operation parameter for at least one of the transport system and the plurality of laboratory devices during runtime of the transport system; - in response to receiving the operation data, assigning a second number of additional queue spaces from the plurality of additional queue spaces to the first empty carrier queue by the control device, wherein the second number of additional queue spaces is different from the first number of additional queue spaces; and - operating the first empty carrier queue with the first fixed number of queue spaces plus the second number of additional queue spaces during runtime of the transport system. - a plurality of laboratory devices configured to apply at least one of pre-analytics, analytics, and post-analytics for a sample received in a sample container; - a transport system, comprising - a plurality of carriers each configured to carry one or more sample containers on an automation track to at least one of the plurality of laboratory devices; - a plurality of transport system interfaces; and - a first empty carrier queue provided with a first fixed number of queue spaces which each can be assigned an empty carrier; and - a plurality of carriers each configured to carry one or more sample containers on an automation track to at least one of the plurality of laboratory devices; - a plurality of transport system interfaces; and - a first empty carrier queue provided with a first fixed number of queue spaces which each can be assigned an empty carrier; and - a control device configured to control operation of the transport system; - providing a plurality of additional queue spaces in the transport system, the additional queue spaces each assignable an empty carrier; - assigning a first number of additional queue spaces from the plurality of additional queue spaces to the first empty carrier queue by the control device; - operating the first empty carrier queue with the first fixed number of queue spaces plus the first number of additional queue spaces during runtime of the transport system; - receiving operation data in the control device, the operation data being indicative of a first operation parameter for at least one of the transport system and the plurality of laboratory devices during runtime of the transport system; - in response to receiving the operation data, assigning a second number of additional queue spaces from the plurality of additional queue spaces to the first empty carrier queue by the control device, wherein the second number of additional queue spaces is different from the first number of additional queue spaces; and - operating the first empty carrier queue with the first fixed number of queue spaces plus the second number of additional queue spaces during runtime of the transport system.