A composition comprising: (i) a first cationic lipid at a compositional molar ratio from about 0.18 to about 0.32 and of formula: wherein R 1 and R 2 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 3 and R 4 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; m is an integer from 1 to 6; X a - is an anion; (ii) a second cationic lipid at a compositional molar ratio from about 0.24 to about 0.51 and of formula: wherein R 5 and R 8 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 6 and R 7 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; n is an integer from 1 to 6; and X b - is an anion; (iii) a first helper lipid at a compositional molar ratio from about 0.20 to about 0.32; (iv) a second helper lipid at a compositional molar ratio from about 0.01 to about 0.14; and (v) a biostability enhancing agent at a compositional molar ratio from about 0.01 to about 0.02; wherein said biostability enhancing agent is a PEGylated phospholipid or a polyethylene glycol; wherein said first and second helper lipids are selected from lecithins; phosphotidylethanolamine; phosphatidylethanolamines; phosphotidylcholine; phosphatidylcholines; phosphatidylglycerol; phosphatidylglycerols; phosphatidylserine; phosphatidylserines; fatty acid esters; glycerol esters; sphingolipids; cardolipin; cerebrosides; ceramides; and cholesterol and 3βOH-sterols; and wherein the term "about" means a range extending to ± 10% of the specified value. (i) a first cationic lipid at a compositional molar ratio from about 0.18 to about 0.32 and of formula: wherein R 1 and R 2 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 3 and R 4 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; m is an integer from 1 to 6; X a - is an anion; R 1 and R 2 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 3 and R 4 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; m is an integer from 1 to 6; X a - is an anion; (ii) a second cationic lipid at a compositional molar ratio from about 0.24 to about 0.51 and of formula: wherein R 5 and R 8 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 6 and R 7 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; n is an integer from 1 to 6; and X b - is an anion; R 5 and R 8 are independently hydrogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; R 6 and R 7 are independently unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; n is an integer from 1 to 6; and X b - is an anion; (iii) a first helper lipid at a compositional molar ratio from about 0.20 to about 0.32; (iv) a second helper lipid at a compositional molar ratio from about 0.01 to about 0.14; and (v) a biostability enhancing agent at a compositional molar ratio from about 0.01 to about 0.02; wherein said biostability enhancing agent is a PEGylated phospholipid or a polyethylene glycol; wherein said first and second helper lipids are selected from lecithins; phosphotidylethanolamine; phosphatidylethanolamines; phosphotidylcholine; phosphatidylcholines; phosphatidylglycerol; phosphatidylglycerols; phosphatidylserine; phosphatidylserines; fatty acid esters; glycerol esters; sphingolipids; cardolipin; cerebrosides; ceramides; and cholesterol and 3βOH-sterols; and wherein the term "about" means a range extending to ± 10% of the specified value.