A compound having the Formula I: or a pharmaceutically acceptable salt thereof, wherein each X is independently CH or N; R 1 is methyl; R 2 is hydrogen, halo, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C4)alkoxy, or -CN; R 3 is (C 1 -C 4)alkyl or halo(C 1 -C 4)alkyl; R 4 is (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, halo(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylOH, -(C 1 -C 4)alkylO(C 1 -C 4)alkyl, phenyl, 5-6 membered heteroaryl, monocyclic (C 3 -C 7)cycloalkyl, bridged bicyclic (C 5 -C 8)cycloalkyl, or 4-7 membered monocyclic heterocyclyl, wherein said phenyl, heteroaryl, monocyclic cycloalkyl, bridged bicyclic cycloalkyl, and heterocyclyl are each optionally substituted with 1 to 3 groups selected from R 5; R 5 is selected from (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, halo(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylOH, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, halo, nitrile, amide, urea, carbamate, sulfonamide, hydroxyl, oxo, OR 6, -OC (C 1 -C 4)alkyl, -C (C 1 -C 4)alkyl, -C (C 1 -C 4)alkylOH, -C (C 1 -C 4)alkylNH(C 1 -C 4)alkyl, -C (C 1 -C 4)alkylN((C 1 -C 4)alkyl) 2, -C (C 1 -C 4)alkylNH 2, -SO 2 (C 1 -C 4)alkyl, (C 1 -C 4)alkyl-O-(C 1 -C 4)alkyl, substituted phenyl, 5-6 membered heteroaryl, 4-7 membered heterocyclyl, and NR A R B, wherein said cycloalkyl for R 5 is optionally substituted with -O(C 1 -C 4)alkyl; R A is hydrogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 3 -C 6)cycloalkyl, 4-7 membered heterocyclyl, or (C 1 -C 4)alkyl-O-(C 1 -C 4)alkyl; R B is hydrogen, (C 1 -C 4)alkyl, -(C 3 -C 5)cycloalkyl, or 4-7 membered heterocyclyl, wherein said (C 1 -C 4)alkyl for R B is optionally substituted with 1 to 3 groups selected from halo, phenyl, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, and OH and wherein said heterocyclyl, -(C 3 -C 5)cycloalkyl for R B is optionally substituted with 1 to 3 groups selected from (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, -O(C 1 -C 4)alkyl, and -C(=O)O(C 1 -C 4)alkyl; or R A and R B taken together with the nitrogen atom to which they are attached form a 3-7 membered heterocyclyl optionally substituted with 1 to 3 groups selected from halo,(C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, oxo, halo(C 1 -C 4)alkoxy, 5-6 membered heteroaryl, (C3-C6)cycloalkyl, -SO 2 (C 1 -C 4)alkyl, NMe2, hydroxy, cyano, spirooxetanyl and (C 1 -C4)cycloalkoxy optionally substituted with (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, or (C 1 -C 4)alkoxy; and R 6 is (C 3 -C 6)cycloalkyl, 4-7 membered heterocyclyl, or 5-6 membered heteroaryl, -O(C 1 -C 4)alkyl, wherein said 4-7 membered heterocyclyl and said 5-6 membered heteroaryl for R 6 are each optionally and independently substituted with 1 or 2 (C 1 -C 4)alkyl groups. each X is independently CH or N; R 1 is methyl; R 2 is hydrogen, halo, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C4)alkoxy, or -CN; R 3 is (C 1 -C 4)alkyl or halo(C 1 -C 4)alkyl; R 4 is (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, halo(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylOH, -(C 1 -C 4)alkylO(C 1 -C 4)alkyl, phenyl, 5-6 membered heteroaryl, monocyclic (C 3 -C 7)cycloalkyl, bridged bicyclic (C 5 -C 8)cycloalkyl, or 4-7 membered monocyclic heterocyclyl, wherein said phenyl, heteroaryl, monocyclic cycloalkyl, bridged bicyclic cycloalkyl, and heterocyclyl are each optionally substituted with 1 to 3 groups selected from R 5; R 5 is selected from (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, halo(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylOH, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, halo, nitrile, amide, urea, carbamate, sulfonamide, hydroxyl, oxo, OR 6, -OC (C 1 -C 4)alkyl, -C (C 1 -C 4)alkyl, -C (C 1 -C 4)alkylOH, -C (C 1 -C 4)alkylNH(C 1 -C 4)alkyl, -C (C 1 -C 4)alkylN((C 1 -C 4)alkyl) 2, -C (C 1 -C 4)alkylNH 2, -SO 2 (C 1 -C 4)alkyl, (C 1 -C 4)alkyl-O-(C 1 -C 4)alkyl, substituted phenyl, 5-6 membered heteroaryl, 4-7 membered heterocyclyl, and NR A R B, wherein said cycloalkyl for R 5 is optionally substituted with -O(C 1 -C 4)alkyl; R A is hydrogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 3 -C 6)cycloalkyl, 4-7 membered heterocyclyl, or (C 1 -C 4)alkyl-O-(C 1 -C 4)alkyl; R B is hydrogen, (C 1 -C 4)alkyl, -(C 3 -C 5)cycloalkyl, or 4-7 membered heterocyclyl, wherein said (C 1 -C 4)alkyl for R B is optionally substituted with 1 to 3 groups selected from halo, phenyl, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, and OH and wherein said heterocyclyl, -(C 3 -C 5)cycloalkyl for R B is optionally substituted with 1 to 3 groups selected from (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, -O(C 1 -C 4)alkyl, and -C(=O)O(C 1 -C 4)alkyl; or R A and R B taken together with the nitrogen atom to which they are attached form a 3-7 membered heterocyclyl optionally substituted with 1 to 3 groups selected from halo,(C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, oxo, halo(C 1 -C 4)alkoxy, 5-6 membered heteroaryl, (C3-C6)cycloalkyl, -SO 2 (C 1 -C 4)alkyl, NMe2, hydroxy, cyano, spirooxetanyl and (C 1 -C4)cycloalkoxy optionally substituted with (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, or (C 1 -C 4)alkoxy; and R 6 is (C 3 -C 6)cycloalkyl, 4-7 membered heterocyclyl, or 5-6 membered heteroaryl, -O(C 1 -C 4)alkyl, wherein said 4-7 membered heterocyclyl and said 5-6 membered heteroaryl for R 6 are each optionally and independently substituted with 1 or 2 (C 1 -C 4)alkyl groups.