A non-transitory computer readable medium, comprising instructions for causing a computing environment to perform a method of dynamically adjusting or tuning user alerts based on an estimation or prediction of a user's cognitive awareness of a hypoglycemia or hyperglycemia condition of the user, thereby providing data relevant to treatment of a hypoglycemia or hyperglycemia condition of the user, the method comprising steps of: identifying a current or future hypoglycemia or hyperglycemia condition of the user based on a physiological glucose response experienced by the user passing a glucose threshold, the physiological glucose response including a series of measured glucose concentration values with respect to time; estimating or predicting a cognitive awareness of the user of the identified current or future hypoglycemia or hyperglycemia condition by: quantifying a similarity in the glucose response and a previously measured glucose response of the user that is a prior series of glucose concentration values previously measured for the user; determining if the quantified similarity is greater than a predetermined threshold criterion; estimating or predicting the user to be cognitively aware of the identified current or future hypoglycemia or hyperglycemia condition if the quantified similarity is greater than the predetermined threshold criterion; estimating or predicting the user to be cognitively unaware of the identified current or future hypoglycemia or hyperglycemia condition if the quantified similarity is not greater than the predetermined threshold criterion; and if the result of the estimating or predicting is that the user is cognitively unaware of the identified current or future hypoglycemia or hyperglycemia condition, then alerting the user with a user prompt on a user interface of a monitoring device, the user prompt indicating the identified current or future hypoglycemia or hyperlycemia condition, and if the result of the estimating or predicting is that the user is cognitively aware of the identified current or future hypoglcyemia or hyperglycemia condition, then the user is not alerted with the user prompt indicating the identified current or future hypoglycemia or hyperglycemia condition. identifying a current or future hypoglycemia or hyperglycemia condition of the user based on a physiological glucose response experienced by the user passing a glucose threshold, the physiological glucose response including a series of measured glucose concentration values with respect to time; estimating or predicting a cognitive awareness of the user of the identified current or future hypoglycemia or hyperglycemia condition by: quantifying a similarity in the glucose response and a previously measured glucose response of the user that is a prior series of glucose concentration values previously measured for the user; determining if the quantified similarity is greater than a predetermined threshold criterion; estimating or predicting the user to be cognitively aware of the identified current or future hypoglycemia or hyperglycemia condition if the quantified similarity is greater than the predetermined threshold criterion; quantifying a similarity in the glucose response and a previously measured glucose response of the user that is a prior series of glucose concentration values previously measured for the user; determining if the quantified similarity is greater than a predetermined threshold criterion; estimating or predicting the user to be cognitively aware of the identified current or future hypoglycemia or hyperglycemia condition if the quantified similarity is greater than the predetermined threshold criterion; estimating or predicting the user to be cognitively unaware of the identified current or future hypoglycemia or hyperglycemia condition if the quantified similarity is not greater than the predetermined threshold criterion; and if the result of the estimating or predicting is that the user is cognitively unaware of the identified current or future hypoglycemia or hyperglycemia condition, then alerting the user with a user prompt on a user interface of a monitoring device, the user prompt indicating the identified current or future hypoglycemia or hyperlycemia condition, and if the result of the estimating or predicting is that the user is cognitively aware of the identified current or future hypoglcyemia or hyperglycemia condition, then the user is not alerted with the user prompt indicating the identified current or future hypoglycemia or hyperglycemia condition.