A compound of formula or its salts thereof, wherein R 1 is selected from the group consisting of optionally substituted arylalkyl, optionally substituted aryl, optionally substituted heteroarylalkyl and optionally substituted heteroaryl; R 2 is selected from the group consisting of optionally substituted sulfonyl and optionally substituted sulfamoyl; R 3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino carbonyl, optionally substituted amino or nitrile; X 1 is selected from a group consisting of CR 7 R 8, C(=O), C(=NH), NR 9, NHC(=O) and SO 2, wherein R 7 and R 8 are independently selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl and optionally substituted heteroaryl or R 7 and R 8 together form an optionally substituted C 4-6 cycloalkyl ring; R 9 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl and optionally substituted heteroaryl; and A represents an optionally substituted saturated or partially saturated 4-7 membered ring with the general formula or is selected from wherein for each occurrence X 2 is CH or N; X 3 is C(R 5) 2, N(R 5b), O or S; X 4 is independently selected from C(=O), or C(R 4) 2; R 4 for each occurrence is independently hydrogen, halogen, optionally substituted amino, hydroxyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R 5 for each occurrence is independently hydrogen, halogen, optionally substituted amino, hydroxyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted alkanoyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R 5b is hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; and n = 1 or 2; wherein "alkyl" refers to a linear or branched alkyl group or moiety, which may also be an "unsaturated alkyl" moiety, containing at least one alkene or alkyne moiety and wherein "cycloalkyl" refers to mono- or bicyclic ring or ring systems consisting of 3 to 11 carbon atoms, which may also be an "unsaturated ring" containing at least one alkene or alkyne moiety and provided that the ring system is not aromatic; wherein, when an alkyl group is optionally substituted, it is substituted by one, two or three substituents selected from cyano, halogen, hydroxyl, alkylamino, dialkylamino, amido, alkylamido, dialkylamido, alkanoyl, alkoxy, sulfonamido, nitro, aryl and heteroaryl; wherein, when an aryl group is optionally substituted, it is substituted by one or more groups selected from cyano, halogen, hydroxyl, nitro, trifluoromethyl, alkyl, alkylthio, alkoxy, amino, alkylamino, dialkylamino, alkanoyl, amido, N -alkylamido, N,N- dialkylamino, sulfonamido, aryl and heteroaryl; wherein, when a sulfonyl group is optionally substituted, it is substituted by one or more substituents selected from cycloalkyl, -O-C(halogen) 3 preferably -OCF 3, biaryl, carbocyclic aryl, heteroalicyclic, heteroaryl, acyl, amidino, amido, amino, alkyloxyamino, carbamoyl, carboxy, cyano, ether, hydroxyl, imino, halo, nitro, sulfamoyl, sulfonyl, sulfinyl, sulfenyl, sulfonamido or urea; wherein, when a group other than an alkyl, aryl or sulfonyl group is optionally substituted, it is substituted by one or more substituents selected from alkyl, cycloalkyl, -O-C(halogen) 3 preferably -OCF 3, biaryl, carbocyclic aryl, heteroalicyclic, heteroaryl, acyl, amidino, amido, amino, alkyloxyamino, carbamoyl, carboxy, cyano, ether, hydroxyl, imino, halo, nitro, sulfamoyl, sulfonyl, sulfinyl, sulfenyl, sulfonamido or urea; and wherein the compound is not tert -butyl 4-(4-(N-(2,3-dichlorobenzyl)methylsulfonamido)benzyl)piperazine-1-carboxylate, N -benzyl- N -[4-(1-piperidinylcarbonyl)phenyl]benzenesulfonamide, N -[(4-chlorophenyl)methyl]-4-methyl- N -[4-(4-morpholinyl)phenyl]benzenesulfonamide, and 1-[4-[(phenylmethyl)(phenylsulphonyl)amino]benzoyl]piperidine.