mhurhangee/ep-ind-claims huggingface dataset:
An rAAV2 particle comprising an AAV2 capsid protein and a vector comprising a nucleic acid encoding a protective ApoE ε2 isoform protein inserted between a pair of AAV2 inverted terminal repeats, for use in treating Alzheimer's disease in a mammal, wherein the rAAV particle is administered to an ependymal cell thereby delivering the nucleic acid to the ependymal cell, wherein the ependymal cell secretes the ApoE ε2 protein so as to treat the disease, and wherein the mammal is a non-rodent mammal.
A light fixture including: - a plurality of elongate members each extending between opposed ends and carrying at least one light radiation source, - at least one hinge member for mechanically coupling one end of one of said elongate members to one end of another of said elongate members, said hinge member allowing the orientation of said one and said other elongate members between: - an open position, wherein said one and said other elongate members extend in sequence with each other in a common direction, and - a closed position, wherein said one and said other elongate members extend side by side, characterized in that the light fixture includes, between said at least one hinge member and each of said one and said other elongate members, an electrical connection device including: - curved electrically conductive lines, and - slider contacts for slidably contacting said curved conductive lines, wherein said at least one hinge member carries parts of two opposed pin-and-hole (18, 20) coupling arrangements for coupling to said one and said other of said elongate members, and said pin-and-hole coupling arrangement includes a pin which is radially contractible for insertion into a corresponding hole. - a plurality of elongate members each extending between opposed ends and carrying at least one light radiation source, - at least one hinge member for mechanically coupling one end of one of said elongate members to one end of another of said elongate members, said hinge member allowing the orientation of said one and said other elongate members between: - an open position, wherein said one and said other elongate members extend in sequence with each other in a common direction, and - a closed position, wherein said one and said other elongate members extend side by side, - curved electrically conductive lines, and - slider contacts for slidably contacting said curved conductive lines,
Mechanism for unlocking an elevated lower rack for an arrangement for a dishwasher being capable of elevating the lower rack from a lower position to an upper position and locking the elevated lower rack in the upper position, the elevating arrangement comprising: a spring loaded pivot arm arrangement to be attached in one end to a tub of the dishwasher and in another end to the lower rack for elevating the lower rack from the lower position inside the tub to the upper position at least partially outside the tub; a locking mechanism arranged between the spring loaded pivot arm arrangement and the lower rack and configured to lock the spring loaded pivot arm arrangement when the lower rack has been elevated to the upper position, thereby fixing the lower rack in the upper position; the mechanism for unlocking the elevated lower rack being characterized in comprising: a lever extending from a front of the lower rack along each side of the lower rack to the locking mechanism being located at a respective side of the rack, wherein user operation of the lever at the front of the elevated lower rack causes a respective end of the lever to act on the locking mechanism located at the respective side of the rack to unlock the elevated lower rack such that it can be lowered into its lower position. a spring loaded pivot arm arrangement to be attached in one end to a tub of the dishwasher and in another end to the lower rack for elevating the lower rack from the lower position inside the tub to the upper position at least partially outside the tub; a locking mechanism arranged between the spring loaded pivot arm arrangement and the lower rack and configured to lock the spring loaded pivot arm arrangement when the lower rack has been elevated to the upper position, thereby fixing the lower rack in the upper position; the mechanism for unlocking the elevated lower rack being characterized in comprising: a lever extending from a front of the lower rack along each side of the lower rack to the locking mechanism being located at a respective side of the rack, wherein user operation of the lever at the front of the elevated lower rack causes a respective end of the lever to act on the locking mechanism located at the respective side of the rack to unlock the elevated lower rack such that it can be lowered into its lower position.
Facility for the production of packaged product stacks of folded, or unfolded, product blanks made from paper, cellulose, or similar, in particular of hygiene products, with at least two stacking units, which are connected in parallel on the product flow side, for the formation of the product stacks from the product blanks, downstream of which stacking units a common packaging unit is connected on the product flow side by way of a conveyor system, characterised in that the conveyor system comprises a first conveyor, which is associated with one of the stacking units, and comprises at least one part, and a second conveyor, which is associated with a second stacking unit, and comprises a plurality of parts.
Domestic appliance, in particular water-conducting domestic appliance, at least having a pedestal which is embodied to have an adjustable height by means of a thread, wherein there is provision for clamping regions which bring about an increase in the force required for actuation of the thread, and wherein the at least one pedestal has an internal thread disposed on an internal wall and there is provision for an external thread interacting with the internal thread, characterised in that the internal thread has a single path, and at least one thicker section is arranged on the internal wall independent from the internal thread, in the region of which thicker section the radius of the internal wall is smaller than the external radius of the external thread.
A moving body tracking method comprising: controlling a processor to perform the steps of: detecting, by a tracking unit a first position of a moving body in each image frame of a plurality of frame images which configure a video, detecting, by a trajectory detector independently from the detecting of the first position, a trajectory of the moving body in a unit of the plurality of frame images by using the plurality of frame images, determining (S150, S160) a final position of the moving body in each of the plurality of frame images by selecting either the detected first position or the position of the moving body which is obtained from the detected trajectory, and outputting (S170, S180) the determined final position for each of the plurality of image frames, wherein a time interval for detecting the trajectory of the moving body is greater than a time interval for detecting the first position of the moving body, wherein in the determining (S150, S160), the position of the moving body which is obtained from the detected trajectory is selected in case the difference between the detected first position and the position of the moving body which is obtained from the detected trajectory is equal to or larger than a predetermined value. controlling a processor to perform the steps of: detecting, by a tracking unit a first position of a moving body in each image frame of a plurality of frame images which configure a video, detecting, by a trajectory detector independently from the detecting of the first position, a trajectory of the moving body in a unit of the plurality of frame images by using the plurality of frame images, determining (S150, S160) a final position of the moving body in each of the plurality of frame images by selecting either the detected first position or the position of the moving body which is obtained from the detected trajectory, and outputting (S170, S180) the determined final position for each of the plurality of image frames, detecting, by a tracking unit a first position of a moving body in each image frame of a plurality of frame images which configure a video, detecting, by a trajectory detector independently from the detecting of the first position, a trajectory of the moving body in a unit of the plurality of frame images by using the plurality of frame images, determining (S150, S160) a final position of the moving body in each of the plurality of frame images by selecting either the detected first position or the position of the moving body which is obtained from the detected trajectory, and outputting (S170, S180) the determined final position for each of the plurality of image frames, wherein a time interval for detecting the trajectory of the moving body is greater than a time interval for detecting the first position of the moving body, wherein in the determining (S150, S160), the position of the moving body which is obtained from the detected trajectory is selected in case the difference between the detected first position and the position of the moving body which is obtained from the detected trajectory is equal to or larger than a predetermined value.
A non-aqueous fluoropolymer composition comprising: a) at least one fluorinated ionisable polymer [polymer], which comprises recurring fluorinated blocks and recurring functional blocks, each of said recurring functional blocks comprising at least one ionisable anionic group, and wherein at least one of the said recurring functional blocks is comprised between two fluorinated blocks; and b) at least one fluorinated ionisable polymer [polymer], which comprises recurring fluorinated blocks and recurring functional blocks, each of said recurring functional blocks comprising at least one ionisable cationic group, and wherein at least one of the said recurring functional blocks is comprised between two fluorinated blocks; c) at least one fluorinated solvent; and d) at least one aliphatic straight or branched alcohol containing from 2 to 6 carbon atoms. a) at least one fluorinated ionisable polymer [polymer], which comprises recurring fluorinated blocks and recurring functional blocks, each of said recurring functional blocks comprising at least one ionisable anionic group, and wherein at least one of the said recurring functional blocks is comprised between two fluorinated blocks; and b) at least one fluorinated ionisable polymer [polymer], which comprises recurring fluorinated blocks and recurring functional blocks, each of said recurring functional blocks comprising at least one ionisable cationic group, and wherein at least one of the said recurring functional blocks is comprised between two fluorinated blocks; c) at least one fluorinated solvent; and d) at least one aliphatic straight or branched alcohol containing from 2 to 6 carbon atoms.
A method comprising: receiving, by a computer system (220,320), media content including audio and video; encoding, by a computer system (220,320), the video according to a frame rate; encoding, by a computer system (220,320), the audio according to a codec-enforced frame size; and generating a plurality of content files, wherein each of the plurality of content files comprises an encoded portion of the video having a fixed-time duration and an encoded portion of the audio, characterised in that the encoded portion of the audio has a plurality of full audio frames having the codec-enforced frame size and the duration of the encoded portion of the audio of one or more of the plurality of content files is greater than or less than the fixed-time duration. receiving, by a computer system (220,320), media content including audio and video; encoding, by a computer system (220,320), the video according to a frame rate; encoding, by a computer system (220,320), the audio according to a codec-enforced frame size; and generating a plurality of content files, wherein each of the plurality of content files comprises an encoded portion of the video having a fixed-time duration and an encoded portion of the audio, characterised in that the encoded portion of the audio has a plurality of full audio frames having the codec-enforced frame size and the duration of the encoded portion of the audio of one or more of the plurality of content files is greater than or less than the fixed-time duration.
A method for inspection of an object comprising: illuminating the object with a radiation beam, analyzing secondary photon emissions from the object with time resolved spectroscopy, and determining that a particle is present if a time resolved spectroscopic signal is detected which is different from a signal that would be emitted by the object in the absence of a particle; characterised in that: said step of illuminating the object with a radiation beam comprises providing offaxis illumination (978, 980) from more than one direction. illuminating the object with a radiation beam, analyzing secondary photon emissions from the object with time resolved spectroscopy, and determining that a particle is present if a time resolved spectroscopic signal is detected which is different from a signal that would be emitted by the object in the absence of a particle; characterised in that: said step of illuminating the object with a radiation beam comprises providing offaxis illumination (978, 980) from more than one direction.
Device for the continuous heating of foodstuffs, having a channel which disposed to receive electrically conductive liquid and on the side walls of which opposing electrodes are arranged in pairs and are connected to a current source, a first pair (1, 1a) of opposing electrodes being arranged on the side walls and a second pair of opposing electrodes (2, 2a) being arranged at a distance therefrom along the channel which are in electrical contact with the interior of the channel, characterized in that each pair of opposing electrodes (1, 1a, 2, 2a) being electrically connected to a respective separate secondary winding (S1, S2) of a transformer of the current source and all secondary windings (S1, S2) being energised by at least one primary winding.
A vascular prosthesis comprising: a plurality of wires woven together to form a tubular shape with a plurality of loops on each end of the tubular shape; characterized by each of said plurality of loops terminating with a cap having a cylindrical body and a rounded distal end; said cap comprising a trimmed first wire end, a trimmed second wire end, and a metal tube positioned flush over and melted together with said trimmed first wire end and said trimmed second wire end. a plurality of wires woven together to form a tubular shape with a plurality of loops on each end of the tubular shape; characterized by each of said plurality of loops terminating with a cap having a cylindrical body and a rounded distal end; said cap comprising a trimmed first wire end, a trimmed second wire end, and a metal tube positioned flush over and melted together with said trimmed first wire end and said trimmed second wire end.
A method of treating a surface of an abrasive particle having chemically-bound surface hydroxyl groups, the method comprising: providing an adhesion promoter comprising at least one ring-opened adduct of: a) a polyepoxide having at least two epoxy groups; b) an aminosilane represented by the formula HNR 1 R 2 wherein R 1 and R 2 independently represent -Z-SiL 3, wherein each Z independently represents a divalent linking group having from 1 to 12 carbon atoms, and wherein each L independently represents a hydrolyzable group, and c) an isocyanatosilane represented by the formula O=C=N-Z-SiL 3 wherein Z and L are as previously defined; and contacting the adhesion promoter with the surface of the abrasive particle. providing an adhesion promoter comprising at least one ring-opened adduct of: a) a polyepoxide having at least two epoxy groups; b) an aminosilane represented by the formula HNR 1 R 2 wherein R 1 and R 2 independently represent -Z-SiL 3, wherein each Z independently represents a divalent linking group having from 1 to 12 carbon atoms, and wherein each L independently represents a hydrolyzable group, and c) an isocyanatosilane represented by the formula O=C=N-Z-SiL 3 wherein Z and L are as previously defined; and a) a polyepoxide having at least two epoxy groups; b) an aminosilane represented by the formula HNR 1 R 2 wherein R 1 and R 2 independently represent -Z-SiL 3, wherein each Z independently represents a divalent linking group having from 1 to 12 carbon atoms, and wherein each L independently represents a hydrolyzable group, and c) an isocyanatosilane represented by the formula O=C=N-Z-SiL 3 wherein Z and L are as previously defined; and contacting the adhesion promoter with the surface of the abrasive particle.
A cryogen-free cooling apparatus for cooling a sample, comprising - a vacuum chamber (101, 112), - a first cooling device (100, 110) which is configured to generate a first temperature in the vacuum chamber (101, 112) to provide a main thermal bath, - a second cooling device, which is in connection with a sample stage on which a sample is to be arranged, wherein the second cooling device is a solid state cooler which is configured to provide a second temperature to the sample stage, and wherein the second temperature is different from the first temperature, and - a sample loading device, wherein the sample stage is held in the vacuum chamber (101, 112) by a first mechanical suspension of low thermal conductivity such that the sample stage is thermally decoupled from the main thermal bath, characterized in that - the first mechanical suspension is provided by a plurality of first fibers, and - the sample loading device is configured to change the sample while operating the first cooling device (100, 110) and the second cooling device. - a vacuum chamber (101, 112), - a first cooling device (100, 110) which is configured to generate a first temperature in the vacuum chamber (101, 112) to provide a main thermal bath, - a second cooling device, which is in connection with a sample stage on which a sample is to be arranged, wherein the second cooling device is a solid state cooler which is configured to provide a second temperature to the sample stage, and wherein the second temperature is different from the first temperature, and - a sample loading device, wherein the sample stage is held in the vacuum chamber (101, 112) by a first mechanical suspension of low thermal conductivity such that the sample stage is thermally decoupled from the main thermal bath, characterized in that - the first mechanical suspension is provided by a plurality of first fibers, and - the sample loading device is configured to change the sample while operating the first cooling device (100, 110) and the second cooling device.
An output power distribution module, comprising a first power distribution control module and a second power distribution control module arranged symmetrically on opposite sides of the output power distribution module with an intermediate framework positioned between, wherein a power board, a monitor board, an output circuit breaker, and a customer wiring terminal are integrated inside each power distribution control module; input copper bars are integrated on the intermediate framework inside the power distribution module; the input copper bars are connected to the power board, the monitor board, and the output circuit breaker of the power distribution control modules by using a cable; the input copper bars are configured to bear a current inside a power distribution cabinet, and transmit an output value of the current to an adjacent output power distribution module; and the input copper bars are further configured to distribute, by using the cable, an input current to the power board, the monitor board, and the output circuit breaker of the power distribution control modules, and the output circuit breaker of each power distribution control module is configured to output an input current to the customer wiring terminal.
Trametinib for use in the treatment of a neurodegenerative disease due to neuronal loss or damage, wherein the neurodegenerative disease is selected from the group consisting of Alzheimer's disease, amyotrophic lateral sclerosis (ALS, Lou-Gehrig's disease), dementia, vascular dementia, frontotemporal dementia, Lewy body dementia, multiple system atrophy, corticobasal degeneration, progressive supranuclear palsy, Huntington's disease, primary lateral sclerosis, spinal muscular atrophy, progressive bulbar palsy, progressive muscular atrophy, pseudobulbar palsy, hereditary spastic paraplegia and cerebellar ataxia.
A method of forming a superconductor device interconnect structure, the method comprising: forming a first dielectric layer overlying a substrate; forming a superconducting interconnect element in the first dielectric layer, the superconducting interconnect element having a top surface aligned with a top surface of the first dielectric layer to form a first interconnect layer; moving the superconductor device interconnect structure into a dielectric deposition chamber; performing a nitrogen trifluoride (NF 3) based plasma clean etch process on a top surface of the first interconnect layer in the dielectric deposition chamber to remove oxidization from a top surface of the first interconnect layer; pumping the NF 3 based plasma and argon (Ar) gas from the dielectric deposition chamber while maintaining flow of N 2 gas into the dielectric deposition chamber; and depositing a second dielectric layer over the first interconnect layer in the dielectric deposition chamber. forming a first dielectric layer overlying a substrate; forming a superconducting interconnect element in the first dielectric layer, the superconducting interconnect element having a top surface aligned with a top surface of the first dielectric layer to form a first interconnect layer; moving the superconductor device interconnect structure into a dielectric deposition chamber; performing a nitrogen trifluoride (NF 3) based plasma clean etch process on a top surface of the first interconnect layer in the dielectric deposition chamber to remove oxidization from a top surface of the first interconnect layer; pumping the NF 3 based plasma and argon (Ar) gas from the dielectric deposition chamber while maintaining flow of N 2 gas into the dielectric deposition chamber; and depositing a second dielectric layer over the first interconnect layer in the dielectric deposition chamber.