mhurhangee/ep-ind-claims huggingface dataset:
An in-vitro method for inducing differentiation of oral mucosa stem cells (OMSC), the method comprising: (a) incubating oral mucosa stem cells (OMSC) obtained from oral mucosa in a pre-differentiating medium capable of inducing the differentiation of OMSC toward a specific neural lineage for 24-96 hours, wherein the pre-differentiating medium comprises N-2 supplement, basic fibroblast growth factor 2 (bFGF) and epidermal growth factor; and (b) incubating the OMSC of (a) in a differentiating medium comprising 0.1-5% B27, 85-750 ng/mL Sonic Hedgehog, 30-300ng/mL Wnt-1, 30-300ng/mL FGF-8, 15-150 ng/mL BDNF, 15-150ng/mL bFGF, and 65-600 ng/mL ascorbic acid, for at least 11 days, and thereby differentiated into dopaminergic neural cells. (a) incubating oral mucosa stem cells (OMSC) obtained from oral mucosa in a pre-differentiating medium capable of inducing the differentiation of OMSC toward a specific neural lineage for 24-96 hours, wherein the pre-differentiating medium comprises N-2 supplement, basic fibroblast growth factor 2 (bFGF) and epidermal growth factor; and (b) incubating the OMSC of (a) in
A compound of formula wherein R 1: is a heteroaryl-group selected from the group consisting of [1,3,4]thiadiazol-2-yl, isoxazol-5-yl, thiazol-5-yl-, oxazol-2-yl, pyridin-2-yl and pyrimidin-2-yl, whereby said heteroaryl-group optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, CN-, methyl and H 2 N-; R 2: is selected from the group consisting of fluorine, NC-, F 3 C-, HF 2 C-, FH 2 C- and methyl,; D: is selected from the group consisting of cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl, 2-, 3- and 4-pyridyl, whereby cyclopentyl and cyclohexyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, F 3 C-, HF 2 C- and FH 2 C-; whereby tetrahydrofuranyl and tetrahydropyranyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, F 3 C-, HF 2 C- and FH 2 C-; whereby pyridyl optionally may be substituted by 1, 2, 3 or 4 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, NC-, F 3 C-, HF 2 C-, FH 2 C-, F 3 C-CH 2 - and methyl; m: is selected from 1 or 2; n: is selected from 0, 1 or 2, whereby if n = 2, these two groups R 2 are selected independently of one another; and salts, and the solvates thereof. R 1: is a heteroaryl-group selected from the group consisting of [1,3,4]thiadiazol-2-yl, isoxazol-5-yl, thiazol-5-yl-, oxazol-2-yl, pyridin-2-yl and pyrimidin-2-yl, whereby said heteroaryl-group optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, CN-, methyl and H 2 N-; R 2: is selected from the group consisting of fluorine, NC-, F 3 C-, HF 2 C-, FH 2 C- and methyl,; D: is selected from the group consisting of cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl, 2-, 3- and 4-pyridyl, whereby cyclopentyl and cyclohexyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, F 3 C-, HF 2 C- and FH 2 C-; whereby tetrahydrofuranyl and tetrahydropyranyl optionally may be substituted by 1 or 2 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, F 3 C-, HF 2 C- and FH 2 C-; whereby pyridyl optionally may be substituted by 1, 2, 3 or 4 substituents, whereby said substituents may be selected independently of one another from the group consisting of fluorine, chlorine, bromine, NC-, F 3 C-, HF 2 C-, FH 2 C-, F 3 C-CH 2 - and methyl; m: is selected from 1 or 2; n: is selected from 0, 1 or 2, whereby if n = 2, these two groups R 2 are selected independently of one another; and salts, and the solvates thereof.
A water-absorbent sheet composition comprising a structure in which a water-absorbent resin and a hot melt adhesive are sandwiched with two or more sheets of hydrophilic nonwoven fabrics, wherein the hydrophilic nonwoven fabrics have a basis weight of 50 to 150 g/m 2, and wherein the water-absorbent resin is contained in an amount of from 30 to 100 g/m 2, wherein the hot melt adhesive is contained in an amount of from 0.20 to 0.5 time that of the amount of the water-absorbent resin contained (based on weight), and wherein the water-absorbent sheet composition does not contain hydrophilic fibers between the nonwoven fabrics, characterized in that the water-absorbent resin has a water-retention capacity of physiological saline solution of from 35 to 65 g/g, a water-absorption rate of physiological saline solution of less than 40 s, and a mass-average particle size of 60 to 500 μm, wherein the water-retention capacity, the water-absorption rate, and the mass-average particle size are measured according to the methods described in the description. wherein the hydrophilic nonwoven fabrics have a basis weight of 50 to 150 g/m 2, and wherein the water-absorbent resin is contained in an amount of from 30 to 100 g/m 2, wherein the hot melt adhesive is contained in an amount of from 0.20 to 0.5 time that of the amount of the water-absorbent resin contained (based on weight), and wherein the water-absorbent sheet composition does not contain hydrophilic fibers between the nonwoven fabrics, characterized in that the water-absorbent resin has a water-retention capacity of physiological saline solution of from 35 to 65 g/g, a water-absorption rate of physiological saline solution of less than 40 s, and a mass-average particle size of 60 to 500 μm, wherein the water-retention capacity, the water-absorption rate, and the mass-average particle size are measured according to the methods described in the description.
An artificial, flexible valve to be implanted within a patient's heart, the valve comprising: a stent defining a wall, the stent being serially expandable to accompany a child's growth, wherein the stent comprises metal and a plurality of wires defining a plurality of cells (204; 206) of various sizes; and a plurality of leaflets extending from the wall of the stent, the plurality of leaflets forming a plurality of coaptation regions between two adjacent leaflets, the coaptation regions each having a substantially hyperbolic profile formed in an x-y plane and including extensions along a z-axis beyond a commissure line and adapted and configured to form a releasable, but substantially complete seal when the leaflets are in a closed position, each of the plurality of leaflets having a leaflet-stent attachment line that is substantially elliptical, the height of the coaptation region being enhanced by creating excess length of the leaflet free edges, so that the free edge length is greater than twice the radius of the stent, wherein the height of each of the plurality of coaptation regions dips to form a trough between the outside and the center of the stent, wherein adjacent leaflets are coupled to a wide post of the stent. a stent defining a wall, the stent being serially expandable to accompany a child's growth, wherein the stent comprises metal and a plurality of wires defining a plurality of cells (204; 206) of various sizes; and a plurality of leaflets extending from the wall of the stent, the plurality of leaflets forming a plurality of coaptation regions between two adjacent leaflets, the coaptation regions each having a substantially hyperbolic profile formed in an x-y plane and including extensions along a z-axis beyond a commissure line and adapted and configured to form a releasable, but substantially complete seal when the leaflets are in a closed position, each of the plurality of leaflets having a leaflet-stent attachment line that is substantially elliptical, the height of the coaptation region being enhanced by creating excess length of the leaflet free edges, so that the free edge length is greater than twice the radius of the stent, wherein the height of each of the plurality of coaptation regions dips to form a trough between the outside and the center of the stent, wherein adjacent leaflets are coupled to a wide post of the stent.
A method for operating a laser system, comprising: directing inert gas against an object within a cavity of a collection device; forming an aperture in the object by ablating the object with a laser beam that travels within the cavity and to the object; removing byproducts of the ablation from the cavity; and characterised by directing gas into the cavity proximate a lens; wherein: the laser beam travels from the lens, within the cavity, to the object; the byproducts are removed from the cavity through an outlet of the collection device; the inert gas is directed into the cavity through a first inlet of the collection device positioned between the object and the outlet; the gas is directed into the cavity through a second inlet of the collection device positioned between the lens and the outlet; the laser system further comprises a laser scanner head adapted to receive the laser beam and scan this laser beam over at least a portion of the object; and the collection device is mated to the scanning head. directing inert gas against an object within a cavity of a collection device; forming an aperture in the object by ablating the object with a laser beam that travels within the cavity and to the object; removing byproducts of the ablation from the cavity; and characterised by directing gas into the cavity proximate a lens; wherein: the laser beam travels from the lens, within the cavity, to the object; the byproducts are removed from the cavity through an outlet of the collection device; the inert gas is directed into the cavity through a first inlet of the collection device positioned between the object and the outlet; the gas is directed into the cavity through a second inlet of the collection device positioned between the lens and the outlet; the laser system further comprises a laser scanner head adapted to receive the laser beam and scan this laser beam over at least a portion of the object; and the collection device is mated to the scanning head. the laser beam travels from the lens, within the cavity, to the object; the byproducts are removed from the cavity through an outlet of the collection device; the inert gas is directed into the cavity through a first inlet of the collection device positioned between the object and the outlet; the gas is directed into the cavity through a second inlet of the collection device positioned between the lens and the outlet; the laser system further comprises a laser scanner head adapted to receive the laser beam and scan this laser beam over at least a portion of the object; and the collection device is mated to the scanning head.
Vehicle with an obstacle deflector, the vehicle having a carbodyshell with a front end, the obstacle deflector comprising: - a support member (18, 26) arranged to be fixed at a proximate end to the a front end of the carbodyshell; - a moving element (16, 24) supported by said support member (18, 26) so as to be slideably movable with respect to the support member (18, 26); - a shield element fixed to a front end (16a, 24a) the moving element (16, 24); wherein the moving element (16, 24) is arranged to move between: - an extended position, wherein the shield element is spaced from a distal end (18b, 26b) of the support member (18, 26) and is arranged to push away an obstacle placed in front of the rail vehicle; and - a retracted position, wherein the shield element is in contact with the distal end (18b, 26b) of the support member and is arranged not to push away said obstacle, wherein when the moving element (16, 24) is in the retracted position, the shield element is moved backwards with respect to the position it has when the moving element (16, 24) is in the extended position; wherein in the extended position, the shield element is arranged to project forward beyond a distal end of energy absorber elements fixed to the front end of the carbodyshell; and in the retracted position, the shield element is arranged not to project beyond the distal end of the energy absorber elements. - a support member (18, 26) arranged to be fixed at a proximate end to the a front end of the carbodyshell; - a moving element (16, 24) supported by said support member (18, 26) so as to be slideably movable with respect to the support member (18, 26); - a shield element fixed to a front end (16a, 24a) the moving element (16, 24); wherein the moving element (16, 24) is arranged to move between: - an extended position, wherein the shield element is spaced from a distal end (18b, 26b) of the support member (18, 26) and is arranged to push away an obstacle placed in front of the rail vehicle; and - a retracted position, wherein the shield element is in contact with the distal end (18b, 26b) of the support member and is arranged not to push away said obstacle,
A lifeline system, comprising: a lifeline; a drum assembly around which the lifeline is coiled, the drum assembly being rotatable about a first axis in a first direction during extension of the lifeline and in a second direction, opposite of the first direction, during retraction of the lifeline; a tensioning mechanism in operative connection with the drum assembly to impart a biasing force on the drum assembly to bias the drum assembly to rotate about the first axis in the second direction; and a braking mechanism in operative connection with the drum assembly, the braking mechanism comprising a catch that is rotatable about a second axis that is not concentric with the first axis, the second axis being operatively connected to the first axis so that the second axis rotates about the first axis in the same direction as the drum assembly when the drum assembly is rotating about the first axis, the catch rotating about the second axis in the second direction when the drum assembly is rotated in the first direction at at least a determined angular acceleration to cause an abutment section of the catch to abut an abutment member of the lifeline system and stop the rotation of the drum assembly, characterized in that a center of mass of the catch is located generally upon the second axis. a lifeline; a drum assembly around which the lifeline is coiled, the drum assembly being rotatable about a first axis in a first direction during extension of the lifeline and in a second direction, opposite of the first direction, during retraction of the lifeline; a tensioning mechanism in operative connection with the drum assembly to impart a biasing force on the drum assembly to bias the drum assembly to rotate about the first axis in the second direction; and a braking mechanism in operative connection with the drum assembly, the braking mechanism comprising a catch that is rotatable about a second axis that is not concentric with the first axis, the second axis being operatively connected to the first axis so that the second axis rotates about the first axis in the same direction as the drum assembly when the drum assembly is rotating about the first axis, the catch rotating about the second axis in the second direction when the drum assembly is rotated in the first direction at at least a determined angular acceleration to cause an abutment section of the catch to abut an abutment member of the lifeline system and stop the rotation of the drum assembly, characterized in that a center of mass of the catch is located generally upon the second axis.
A method, comprising: measuring gas pressure at a first device to obtain a first gas pressure value; determining that the first gas pressure value exceeds a first threshold value; sending at least one of the first gas pressure value or an indication that the first gas pressure value exceeds the first threshold value to a second device; receiving information comprising at least one of a second gas pressure value indicating gas pressure at the second device or an indication of whether the second gas pressure value exceeds a second threshold value; reporting at least one of: a high gas-pressure event at the first device based at least in part on the second gas pressure value being at or below the second threshold value; or a high gas-pressure event within a distribution area comprising the first device and the second device based at least in part on the second gas pressure value exceeding the second threshold value; and responsive to determining that the first gas pressure value exceeds the first threshold value, closing a valve of the first device. measuring gas pressure at a first device to obtain a first gas pressure value; determining that the first gas pressure value exceeds a first threshold value; sending at least one of the first gas pressure value or an indication that the first gas pressure value exceeds the first threshold value to a second device; receiving information comprising at least one of a second gas pressure value indicating gas pressure at the second device or an indication of whether the second gas pressure value exceeds a second threshold value; reporting at least one of: a high gas-pressure event at the first device based at least in part on the second gas pressure value being at or below the second threshold value; or a high gas-pressure event within a distribution area comprising the first device and the second device based at least in part on the second gas pressure value exceeding the second threshold value; and a high gas-pressure event at the first device based at least in part on the second gas pressure value being at or below the second threshold value; or a high gas-pressure event within a distribution area comprising the first device and the second device based at least in part on the second gas pressure value exceeding the second threshold value; and responsive to determining that the first gas pressure value exceeds the first threshold value, closing a valve of the first device.
A recharging system comprising: an implantable medical device comprising a secondary recharge coil, a rechargeable power source, and an internal telemetry coil; and a recharging unit comprising: a primary recharge coil configured to inductively couple to the secondary recharge coil to establish a recharge session to recharge the rechargeable power source; an external telemetry coil configured to exchange a telemetry signal with the internal telemetry coil of the IMD; and wherein said implantable medical device and/or said recharging unit further comprises a communication circuit (86,88,47) coupled to receive, and configured to provide an indication of signal strength of the exchanged telemetry signal; and wherein said recharging unit further comprises a control circuit coupled and adapted to receive the indication of signal strength, and to determine based on the indication of signal strength whether recharge coupling efficiency is adequate to initiate the recharge session. an implantable medical device comprising a secondary recharge coil, a rechargeable power source, and an internal telemetry coil; and a recharging unit comprising: a primary recharge coil configured to inductively couple to the secondary recharge coil to establish a recharge session to recharge the rechargeable power source; an external telemetry coil configured to exchange a telemetry signal with the internal telemetry coil of the IMD; and wherein said implantable medical device and/or said recharging unit further comprises a communication circuit (86,88,47) coupled to receive, and configured to provide an indication of signal strength of the exchanged telemetry signal; and wherein said recharging unit further comprises a control circuit coupled and adapted to receive the indication of signal strength, and to determine based on the indication of signal strength whether recharge coupling efficiency is adequate to initiate the recharge session. a primary recharge coil configured to inductively couple to the secondary recharge coil to establish a recharge session to recharge the rechargeable power source; an external telemetry coil configured to exchange a telemetry signal with the internal telemetry coil of the IMD; and wherein said implantable medical device and/or said recharging unit further comprises a communication circuit (86,88,47) coupled to receive, and configured to provide an indication of signal strength of the exchanged telemetry signal; and wherein said recharging unit further comprises a control circuit coupled and adapted to receive the indication of signal strength, and to determine based on the indication of signal strength whether recharge coupling efficiency is adequate to initiate the recharge session.
An apparatus for the manufacture of snack foods, the apparatus comprising a conveyor having an upstream end and a downstream end, a flat bed microwave apparatus for cooking products conveyed through the microwave apparatus by the conveyor, the microwave apparatus having an upstream end and a downstream end defining at least one elongate cavity therebetween and the conveyor extending through the at least one elongate cavity, the microwave apparatus being configured to define a plurality of successive independent microwave zones between the upstream and downstream ends of the microwave apparatus, each zone having a respective microwave attenuator at an upstream inlet and at a downstream outlet, the microwave zones comprising a first preheating zone located towards the upstream end of the microwave apparatus, at least one second explosive dehydration zone located downstream of the first preheating zone, and a third moisture levelling zone located downstream of the at least one second explosive dehydration zone, wherein the microwave apparatus is adapted respectively to provide first, second and third microwave power values to the respective first, second and third zones, the first microwave power value being lower than the second microwave power value.