A security seal comprising a main body within which is bound a first end of a cable and a channel within which is adapted to enter a free end of said cable in a direction of insertion to obtain the closure of said seal, said security seal further comprises: - a first locking device comprising a first spring fixed to said main body, said first spring supporting at its head a first retaining element movable between a rest position in which is retracted from said channel and a position of interference within said channel with said free end of said cable, wherein in said position of interference said first retaining element abuts against said free end of said cable to lock its sliding due to the push exerted by said spring; the security seal being characterized in that it further comprises: - safety means comprising a tab reversibly engaged with said first locking device, the disengagement of said tab from said first locking device allowing the extension of said first spring and the movement of said first locking device to said position of interference; - first RFID detection means connected to said safety means via a frangible electrical connection, whereby the disengagement of said safety means causes the fracture of said frangible electrical connection and their contextual change of state related to a condition of closing of the seal; - wherein said first end of said cable is connected to said main body through anti-tampering means, said anti-tampering means comprising an anti-tampering spring that extends by the cutting of said cable; - second detection RFID means connected to said anti-tampering spring via a frangible electrical connection, the extensions of said anti-tampering spring breaking said frangible electrical connection, such fracture resulting in the change of state of said second detection RFID means correlated to a condition of a tampering of the seal. - a first locking device comprising a first spring fixed to said main body, said first spring supporting at its head a first retaining element movable between a rest position in which is retracted from said channel and a position of interference within said channel with said free end of said cable, wherein in said position of interference said first retaining element abuts against said free end of said cable to lock its sliding due to the push exerted by said spring; the security seal being characterized in that it further comprises: - safety means comprising a tab reversibly engaged with said first locking device, the disengagement of said tab from said first locking device allowing the extension of said first spring and the movement of said first locking device to said position of interference; - first RFID detection means connected to said safety means via a frangible electrical connection, whereby the disengagement of said safety means causes the fracture of said frangible electrical connection and their contextual change of state related to a condition of closing of the seal; - wherein said first end of said cable is connected to said main body through anti-tampering means, said anti-tampering means comprising an anti-tampering spring that extends by the cutting of said cable; - second detection RFID means connected to said anti-tampering spring via a frangible electrical connection, the extensions of said anti-tampering spring breaking said frangible electrical connection, such fracture resulting in the change of state of said second detection RFID means correlated to a condition of a tampering of the seal. - safety means comprising a tab reversibly engaged with said first locking device, the disengagement of said tab from said first locking device allowing the extension of said first spring and the movement of said first locking device to said position of interference; - first RFID detection means connected to said safety means via a frangible electrical connection, whereby the disengagement of said safety means causes the fracture of said frangible electrical connection and their contextual change of state related to a condition of closing of the seal; - wherein said first end of said cable is connected to said main body through anti-tampering means, said anti-tampering means comprising an anti-tampering spring that extends by the cutting of said cable; - second detection RFID means connected to said anti-tampering spring via a frangible electrical connection, the extensions of said anti-tampering spring breaking said frangible electrical connection, such fracture resulting in the change of state of said second detection RFID means correlated to a condition of a tampering of the seal.