A use of a tetrahydroindole derivative according to Formula: wherein G 1 is selected from the following groups: G 2 is selected from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3 -C 8 -cycloalkyl and optionally substituted heterocycloalkyl; G 3 is -C NR 13 R 14; A 1, A 2, A 3 and A 4 are independently selected from CR 10 or N; B 1, B 2 and B 3 are independently selected from NR 11, O, CR 11 R 12 and S; D 1 and D 2 are CR 11; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 and R 9 are independently selected from H, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C 3 -C 8 -cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted heteroalkyl, OH; NH 2, NHR 15, NHCOR 15, NHSO 2 R 15, SR 15, S R 15, SO 2 R 15, CO 2 H and CONHR 15; R 10 is selected from H; halogen, OH, O-alkyl, NH-Alkyl, N(Alkyl) 2, and optionally substituted alkyl; R 11 and R 12 can be independently absent or when present are selected from H; halogen, optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl; R 13 is selected from optionally substituted amino alkyl and optionally substituted heterocycloalkyl alkyl; R 14 is independently selected from H and optionally substituted alkyl; R 15 is selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted C 3 -C 8 -cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkyl aryl, optionally substituted alkyl heteroaryl, optionally substituted aryl alkyl, optionally substituted heteroaryl alkyl, optionally substituted alkyl C 3 -C 8 -cycloalkyl, optionally substituted alkyl heterocycloalkyl, optionally substituted C 3 -C 8 -cycloalkyl alkyl and optionally substituted heterocycloalkyl alkyl; "-----" is selected from a single and double bond; as well as pharmaceutically acceptable salts and tautomers thereof for the preparation of a medicament for the treatment or prophylaxis of a disease or condition selected from cardiovascular diseases, respiratory disorders, disorders affecting the metabolism, skin and/or bone diseases, neuromuscular degenerative diseases, kidney diseases, reproduction disorders, allergic disorders, traumatisms, septic, hemorrhagic and anaphylactic shock, cancers, diseases or disorders of the gastrointestinal system, diseases or disorders affecting the eye and/or the lens,conditions affecting the inner ear and diseases and/or disorders associated with Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase) selected from inflammatory bowel disease, sepsis, septic shock, adult respiratory distress syndrome, pancreatitis, shock induced by trauma, bronchial asthma, allergic rhinitis, rheumatoid arthritis, chronic rheumatoid arthritis, arteriosclerosis, intracerebral hemorrhage, cerebral infarction, heart failure, myocardial infarction, psoriasis, cystic fibrosis, stroke, acute bronchitis, chronic bronchitis, acute bronchiolitis, chronic bronchiolitis, osteoarthritis, gout, myelitis, ankylosing spondylitis, Reuter syndrome, psoriatic arthritis, spondylarthritis, juvenile arthritis or juvenile ankylosing spondylitis, reactive arthritis, infectious arthritis or arthritis after infection, gonococcal arthritis, tuberculous arthritis, viral arthritis, arthritis by bacteria, syphilitic arthritis, Lyme disease, arthritis induced by "angiitis syndrome," polyarteritis nodosa, anaphylactic angiitis, Luegenec granulomatosis, rheumatoid polymyalgia, articular cell rheumatism, calcium crystal deposition arthritis, pseudogout, non-arthritic rheumatism, bursitis, tendosynovitis, epicondyle inflammation (tennis elbow), carpal tunnel syndrome, disorders by repetitive use (typing), mixed form of arthritis, neuropathic arthropathy, hemorrhagic arthritis, vascular peliosis, hypertrophic osteoarthropathy, multicentric reticulohistiocytosis, arthritis induced by specific diseases, blood pigmentation, sickle cell disease and other hemoglobin abnormality, hyperlipoproteinemia, dysgammaglobulinemia, hyperparathyroidism, acromegaly, familial Mediterranean fever, Bechet's disease, systemic autoimmune disease erythematosus, multiple sclerosis and Crohn's disease or diseases like relapsing polychondritis, chronic inflammatory bowel diseases, wherein "substituted" refers to groups substituted with from 1 to 5 substituents selected from the group consisting of "alkyl," "alkenyl," "alkynyl," "C 3 -C 8 -cycloalkyl," "heterocycloalkyl," "alkyl aryl," "alkyl heteroaryl," "alkyl cycloalkyl," "alkyl heterocycloalkyl," "amino," "aminosulfonyl," "ammonium," "acyl amino," "amino carbonyl," "aryl," "heteroaryl," "sulfinyl," "sulfonyl," "alkoxy," "alkoxy carbonyl," "carbamate," "sulfanyl," "halogen," trihalomethyl, cyano, hydroxy, mercapto and nitro.