mhurhangee/ep-ind-claims huggingface dataset:
A tire (1, 100) for running on rough terrain, the tire (1, 100) comprising a tread portion, wherein the tread portion includes at least three main grooves continuously extending in a zigzag manner in a tire circumferential direction, and at least two land portions demarcated by the main grooves, the main grooves are provided such that zigzag phases thereof coincide with each other, the land portions include a first land portion and a second land portion adjacent to each other via one of the main grooves, the first land portion is divided into a plurality of first blocks by a plurality of first inclined grooves that are inclined in a first direction relative to a tire axial direction, the second land portion is divided into a plurality of second blocks by a plurality of second inclined grooves that are inclined in a second direction, which is opposite to the first direction, relative to the tire axial direction, and the respective first blocks are disposed so as to overlap the respective second blocks in the tire circumferential direction, such that each first block has an overlap length in the tire circumferential direction with the corresponding second block, characterized in that each first block includes a main body that is inclined in the first direction relative to the tire axial direction, and a pair of end portions that are inclined in the second direction relative to the tire axial direction.
An apparatus manufactured using an additive manufacturing process and having a gas filled sealed cavity containing at least two cathodes (1386, 1388) and an anode spaced from the cathodes such that a continuous electric discharge of the gas stimulated between at least one of the cathodes and the anode provides a Boolean function output at the anode corresponding to electrical input signals at two of the cathodes, wherein the apparatus with the cathodes and the anode are additively manufactured.
Dilution refrigeration device for achieving very low temperatures, in particular in the range between one and around 100 millikelvin, comprising a working circuit in the form of a loop containing a cycle fluid comprising a mixture of helium-3 and helium-4, the working circuit comprising a mixing chamber, a boiler and a transfer member, which are disposed in series and fluidically connected via a first set of pipes (2, 4), the first set of pipes (2, 4) being configured to transfer cycle fluid from an outlet of the mixing chamber to an inlet of the boiler and from an outlet of the boiler to an inlet of the transfer member, the working circuit comprising a second set of pipes connecting an outlet of the transfer member to an inlet of the mixing chamber, the working circuit comprising at least a first portion for heat exchange between at least a part of the first set of pipes (2, 4) and the second set of pipes, the first heat exchange portion being situated between the boiler and the mixing chamber, the device also comprising at least one cooling member (22, 12) which is in heat exchange with the working circuit and is configured to transfer cold energy to the cycle fluid, the device comprising at least one thermally insulated cold box which contains the cryogenic cold parts, characterized in that it comprises at least one cryogenic pumping member situated in the working circuit in the at least one cold box between the boiler and the transfer member.
A library comprising a plurality of polypeptides, each polypeptide comprising an antibody heavy chain variable domain and an antibody light chain variable domain, wherein the heavy chain variable domain comprises: (a) a CDRH1 that comprises a variant amino acid in amino acid positions 28, 30, 31, 32 and 33; (b) a CDRH2 that comprises a variant amino acid in amino acid positions 50, 52, 53, 54, 56 and 58; and (c) a CDRH3 that comprises a variant amino acid in at least one, two, three, four, five, six of amino acid positions 95, 96, 97, 98, 99, 100, 100a, 100b, 100c, 101 and 102; wherein the amino acid positions correspond to the Kabat numbering system; and wherein each variant amino acid of (a) and (b) is encoded by a non-random codon set, and wherein at least 70% or all of the amino acids encoded by the non-random codon set are target amino acids for that amino acid position in antibody variable domains, wherein a target amino acid is an amino acid that belongs to a group of amino acids that are collectively the most commonly occurring amino acids for that amino acid position and are found in that position in at least 70% of all the sequences of known antibody variable domains; and wherein (c) comprises an amino acid sequence: n - X2 - X3 - X4 - D - X6, where: X1 is any naturally occurring amino acid encoded by a codon set of NNK, NNS, DVK, NVT, XYZ or is tryptophan or glycine or mixtures thereof, and n = 4 to 14; X2 is any naturally occurring amino acid encoded by a codon set of KSG, DVK, DSG, NVT, KSG, NNS, XYZ, NNK or is tyrosine, phenylalanine, serine, alanine, glycine, leucine, or tryptophan; X3 is missing when X2 is phenylalanine or leucine, or if present, is alanine, valine, aspartic acid or glycine; X4 is missing when X2 is phenyalanine or leucine, or if present, is methionine; and X6 is tyrosine or valine. (a) a CDRH1 that comprises a variant amino acid in amino acid positions 28, 30, 31, 32 and 33; (b) a CDRH2 that comprises a variant amino acid in amino acid positions 50, 52, 53, 54, 56 and 58; and (c) a CDRH3 that comprises a variant amino acid in at least one, two, three, four, five, six of amino acid positions 95, 96, 97, 98, 99, 100, 100a, 100b, 100c, 101 and 102; X1 is any naturally occurring amino acid encoded by a codon set of NNK, NNS, DVK, NVT, XYZ or is tryptophan or glycine or mixtures thereof, and n = 4 to 14; X2 is any naturally occurring amino acid encoded by a codon set of KSG, DVK, DSG, NVT, KSG, NNS, XYZ, NNK or is tyrosine, phenylalanine, serine, alanine, glycine, leucine, or tryptophan; X3 is missing when X2 is phenylalanine or leucine, or if present, is alanine, valine, aspartic acid or glycine; X4 is missing when X2 is phenyalanine or leucine, or if present, is methionine; and X6 is tyrosine or valine.
A container filling system comprising: a beverage product reservoir; a beverage container filling valve connected to the reservoir and configured to fill containers with beverage product from the reservoir; a vacuum source connected to a fluid space that includes an interior of the reservoir; a pressure control valve connecting the fluid space to a source of fluid at a pressure above an ambient atmospheric pressure, characterized in that the system further comprises: a pressure transducer configured to generate pressure transducer signals indicative of pressures in a flow path between the reservoir interior and the filling valve; and a controller configured to receive input data corresponding to a target pressure value based on a desired flow rate of beverage product through an outlet of the filling valve, wherein the controller is configured to receive the pressure transducer signals (S PT), and configured to generate, based on the received pressure transducer signals and on the input data, pressure valve control signals (S PC) to open and close the pressure valve and maintain a pressure at or near the target pressure in a part of the flow path from the reservoir interior. a beverage product reservoir; a beverage container filling valve connected to the reservoir and configured to fill containers with beverage product from the reservoir; a vacuum source connected to a fluid space that includes an interior of the reservoir; a pressure control valve connecting the fluid space to a source of fluid at a pressure above an ambient atmospheric pressure, characterized in that the system further comprises: a pressure transducer configured to generate pressure transducer signals indicative of pressures in a flow path between the reservoir interior and the filling valve; and a controller configured to receive input data corresponding to a target pressure value based on a desired flow rate of beverage product through an outlet of the filling valve, wherein the controller is configured to receive the pressure transducer signals (S PT), and configured to generate, based on the received pressure transducer signals and on the input data, pressure valve control signals (S PC) to open and close the pressure valve and maintain a pressure at or near the target pressure in a part of the flow path from the reservoir interior. a pressure transducer configured to generate pressure transducer signals indicative of pressures in a flow path between the reservoir interior and the filling valve; and a controller configured to receive input data corresponding to a target pressure value based on a desired flow rate of beverage product through an outlet of the filling valve, wherein the controller is configured to receive the pressure transducer signals (S PT), and configured to generate, based on the received pressure transducer signals and on the input data, pressure valve control signals (S PC) to open and close the pressure valve and maintain a pressure at or near the target pressure in a part of the flow path from the reservoir interior.
A surgical instrument comprising a drive mechanism, wherein said drive mechanism comprises: a motor; a planetary gear train, wherein an input sun gear of said planetary gear train is engaged with an output shaft of said motor, and an output carrier of said planetary gear train is engaged with an executing mechanism of said surgical instrument through a transmission mechanism; and a bidirectional ratchet mechanism comprising a ratchet, a bidirectional pawl assembly, and a stop, wherein said ratchet is in rigid connection with an annular gear of said planetary gear train; said bidirectional pawl assembly comprises a bidirectional pawl; said stop may selectively be actuated to drive a first end or a second end of said bidirectional pawl to lock said ratchet, and when the surgical instrument is in one operating mode, said planetary gear train is driven by said motor, and said annular gear of said planetary gear train is locked from rotating in a corresponding direction, and when the surgical instrument is in another operating mode, said planetary gear train is driven manually through said transmission mechanism, and said annular gear is free to rotate in a corresponding direction. a motor; a planetary gear train, wherein an input sun gear of said planetary gear train is engaged with an output shaft of said motor, and an output carrier of said planetary gear train is engaged with an executing mechanism of said surgical instrument through a transmission mechanism; and a bidirectional ratchet mechanism comprising a ratchet, a bidirectional pawl assembly, and a stop, wherein said ratchet is in rigid connection with an annular gear of said planetary gear train; said bidirectional pawl assembly comprises a bidirectional pawl; said stop may selectively be actuated to drive a first end or a second end of said bidirectional pawl to lock said ratchet, and when the surgical instrument is in one operating mode, said planetary gear train is driven by said motor, and said annular gear of said planetary gear train is locked from rotating in a corresponding direction, and when the surgical instrument is in another operating mode, said planetary gear train is driven manually through said transmission mechanism, and said annular gear is free to rotate in a corresponding direction.
An irinotecan formulation including a liposome formed by a membrane of lipid bilayer containing a phospholipid as a main membrane component, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.1 mol/mol (drug mol/membrane total lipid mol), wherein only the outer surface of the liposome is modified with a surface-modifying agent containing a hydrophilic polymer.
A solid tablet that is directly-compressed of powder, comprising meloxicam or a pharmaceutically acceptable salt thereof and excipients, characterized in that (i) the directly-compressed powder was not subjected to a granulation step, (ii) the solid tablet contains 1.0 mg meloxicam, (iii) the solid tablet has a tablet weight of 800 mg, (iv) meloxicam is homogenously dispersed within the solid tablet, (v) the solid tablet has one or two breaking notches/score lines that enable the solid tablet to be broken into two, three or four units with each unit containing equal amounts of the active ingredient, and (vi) the excipients comprise maize starch, microcrystalline cellulose, ferric oxide brown, ferric oxide yellow, sodium citrate dehydrate, anhydrous silicon dioxide, magnesium stearate and an artificial beef flavour. (i) the directly-compressed powder was not subjected to a granulation step, (ii) the solid tablet contains 1.0 mg meloxicam, (iii) the solid tablet has a tablet weight of 800 mg, (iv) meloxicam is homogenously dispersed within the solid tablet, (v) the solid tablet has one or two breaking notches/score lines that enable the solid tablet to be broken into two, three or four units with each unit containing equal amounts of the active ingredient, and (vi) the excipients comprise maize starch, microcrystalline cellulose, ferric oxide brown, ferric oxide yellow, sodium citrate dehydrate, anhydrous silicon dioxide, magnesium stearate and an artificial beef flavour.
Insertion method for inserting in a cell a connector of a terminal crimped at the end of a cable, such that, during said insertion method, the following steps are performed: - Step A: using an insertion clamp (41, 41a, 41b) mounted on a robot adapted to move said insertion clamp in translation in three independent directions (XX', YY', ZZ') and in rotation about each of these three directions, gripping the cable at a gripping point close to the terminal, and positioning the insertion clamp such that, at the gripping point, the cable is substantially tangential to an insertion direction (XX') in which the terminal is inserted in the cell in a coordinate system (OXYZ), - Step B: moving forward the insertion clamp along the insertion direction (XX') to bring the terminal within the field of a first camera (81, 83) and of a second camera (82, 84) whose fields of vision are oriented along two orthogonal axes (ZZ', YY') located in a plane perpendicular to the insertion direction (XX'), characterised by: - Step C: using the images (81a, 82a) formed by each camera in the planes (P 1, P 2) or on axes (YY', ZZ') perpendicular to the axis of each field of vision of said cameras, determining the position in the coordinate system (OXYZ) of a longitudinal axis (LL') of the terminal, - Step D: using the robot, moving the insertion clamp so that the longitudinal axis (LL') of the terminal coincides with the insertion axis (XX') of the terminal in the cell. - Step A: using an insertion clamp (41, 41a, 41b) mounted on a robot adapted to move said insertion clamp in translation in three independent directions (XX', YY', ZZ') and in rotation about each of these three directions, gripping the cable at a gripping point close to the terminal, and positioning the insertion clamp such that, at the gripping point, the cable is substantially tangential to an insertion direction (XX') in which the terminal is inserted in the cell in a coordinate system (OXYZ), - Step B: moving forward the insertion clamp along the insertion direction (XX') to bring the terminal within the field of a first camera (81, 83) and of a second camera (82, 84) whose fields of vision are oriented along two orthogonal axes (ZZ', YY') located in a plane perpendicular to the insertion direction (XX'), characterised by: - Step C: using the images (81a, 82a) formed by each camera in the planes (P 1, P 2) or on axes (YY', ZZ') perpendicular to the axis of each field of vision of said cameras, determining the position in the coordinate system (OXYZ) of a longitudinal axis (LL') of the terminal, - Step D: using the robot, moving the insertion clamp so that the longitudinal axis (LL') of the terminal coincides with the insertion axis (XX') of the terminal in the cell.
A liquid crystal display device comprising a first substrate, a second substrate, a liquid crystal composition layer sandwiched between the first substrate and the second substrate, a color filter constituted by a black matrix and at least RGB three color pixel portions, a pixel electrode, and a common electrode, wherein the liquid crystal composition layer is composed of a liquid crystal composition containing 30% to 50% of a compound represented by general formula wherein R 1 and R 2 each independently represent an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or an alkenyloxy group having 2 to 8 carbon atoms, and A represents a 1,4-phenylene group or a trans-1,4-cyclohexylene group, 5% to 20% of a compound represented by general formula (II-1) wherein R 3 represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or an alkenyloxy group having 2 to 8 carbon atoms, and R 4 represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 4 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or an alkenyloxy group having 3 to 8 carbon atoms, and 25% to 45% of a compound represented by general formula (II-2) wherein R 5 represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or an alkenyloxy group having 2 to 8 carbon atoms; R 6 represents an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 4 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or an alkenyloxy group having 3 to 8 carbon atoms; and B represents a 1,4-phenylene group or a trans-1,4-cyclohexylene group that may be substituted with fluorine, and the RGB three color pixel portions contain, as coloring materials, a diketopyrrolopyrrole pigment and/or an anionic red organic dye in an R pixel portion, at least one selected from the group consisting of a halogenated copper phthalocyanine pigment, a phthalocyanine-based green dye, and a mixture of a phthalocyanine-based blue dye and an azo-based yellow organic dye in a G pixel portion, and an ε-type copper phthalocyanine pigment and/or a cationic blue organic dye in a B pixel portion.
An apparatus for handling a web comprising a processing unit (10; 710) for processing the web and a web transport assembly for transporting the web through a transport path along the processing unit (10; 710), the web transport assembly comprising: - a supply unit arranged for mounting a media roll and for supplying the web from the media roll to the transport path; - a pick-up device (30; 130; 230; 330; 430; 530; 630; 730) comprising a pick-up surface (32; 132; 232; 332; 432; 532; 632; 732) and a holding mechanism (34, 40; 134; 234; 334; 434; 534; 634; 740) configured for releasably holding a leading edge section of the web onto the pick-up surface (32; 132; 232; 332; 432; 532; 632; 732), wherein the pick-up device (30; 130; 230; 330; 430; 530; 630; 730) is moveable between a first position near the supply unit for attaching the leading edge section to the pick-up device (30; 130; 230; 330; 430; 530; 630; 730) and a second position, characterized in that the second position is positioned at an upstream end of a web supporting surface (11; 711) below the processing unit (10; 710). - a supply unit arranged for mounting a media roll and for supplying the web from the media roll to the transport path; - a pick-up device (30; 130; 230; 330; 430; 530; 630; 730) comprising a pick-up surface (32; 132; 232; 332; 432; 532; 632; 732) and a holding mechanism (34, 40; 134; 234; 334; 434; 534; 634; 740) configured for releasably holding a leading edge section of the web onto the pick-up surface (32; 132; 232; 332; 432; 532; 632; 732), wherein the pick-up device (30; 130; 230; 330; 430; 530; 630; 730) is moveable between a first position near the supply unit for attaching the leading edge section to the pick-up device (30; 130; 230; 330; 430; 530; 630; 730) and a second position, characterized in that the second position is positioned at an upstream end of a web supporting surface (11; 711) below the processing unit (10; 710).
FILTERING CIGARETTE HOLDER FOR ROLLING CIGARETTES, particularly for cigarettes of marijuana or other herbs with an analogous psychoactive effect other than tobacco, which, formed from a laminate body of paper-cardboard, is characterized by consisting of a cylinder inside which it comprises a transverse wall with gills defined by grooves that allow molecules to pass but not chippings or particles.
A portable terminal for displaying information in a low power mode, the portable terminal comprising: an application processor; a display unit configured to display information; a proximity detection sensor configured to detect an approach of an object to the portable terminal; a motion detection sensor configured to detect motions and postures of the portable terminal; and a low power detection apparatus configured to: monitor a posture of the portable terminal if the approach of the object to the portable terminal is detected; determine whether the posture of the portable terminal satisfies a preset condition; determine whether the portable terminal is motionless for a preset period of time based on the posture of the portable terminal; and based on determining that the posture of the portable terminal satisfies the preset condition and that the portable terminal is motionless for the preset period of time, provide information on the detected approach to the application processor. an application processor; a display unit configured to display information; a proximity detection sensor configured to detect an approach of an object to the portable terminal; a motion detection sensor configured to detect motions and postures of the portable terminal; and a low power detection apparatus configured to: monitor a posture of the portable terminal if the approach of the object to the portable terminal is detected; determine whether the posture of the portable terminal satisfies a preset condition; determine whether the portable terminal is motionless for a preset period of time based on the posture of the portable terminal; and based on determining that the posture of the portable terminal satisfies the preset condition and that the portable terminal is motionless for the preset period of time, provide information on the detected approach to the application processor. monitor a posture of the portable terminal if the approach of the object to the portable terminal is detected; determine whether the posture of the portable terminal satisfies a preset condition; determine whether the portable terminal is motionless for a preset period of time based on the posture of the portable terminal; and based on determining that the posture of the portable terminal satisfies the preset condition and that the portable terminal is motionless for the preset period of time, provide information on the detected approach to the application processor.
Azeotropic or azeotrope-like composition comprising from 60 to 99 % by weight of E-1,1,1,4,4,4-hexafluoro-2-butene and from 1 to 40 % by weight of at least one chlorotrifluoropropene or from 1 to 30 % by weight of E-1,1,1,4,4,4-hexafluoro-2-butene and from 70 to 99 % by weight of at least one chlorotrifluoropropene.