An aerosolization system, comprising: a respiration system comprising an inspiratory limb (200, 650) and an expiratory limb (202, 652); an aerosolization device (100, 600), comprising: an aerosol chamber (102, 602) having a first end and a second end; an aerosol generator (112, 612) positioned at the first end of the aerosol chamber (102, 602), wherein: the aerosol generator (112, 612) comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator (112, 612); and the aerosol generator (112, 612) is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min; a patient interface that is positioned proximate the second end of the aerosol chamber (102, 602); and a respiratory adaptor (106, 606) that is configured to couple the aerosolization system with the respiration system; at least one breath sensor that is configured to detect an inhalation of a patient; and a controller (1702, 1706) that is configured to actuate the aerosol generator to aerosolize the volume of medicament in synchronization with the detected inhalation; characterized in that: the respiratory adaptor (106, 606) comprises a diversion mechanism that is configured to divert a portion of airflow from the respiration system into the aerosol chamber via at least one airway; and the aerosol chamber (102, 602) is configured to mix the portion of the airflow with aerosolized medicament from the aerosol generator; the diversion mechanism comprises at least one baffle (622, 626) that defines the at least one airway; and the at least one baffle (622, 626) is configured to divert the portion of airflow into the aerosol chamber via the at least one airway and to divert an additional portion of airflow from the inspiratory limb to the expiratory limb. a respiration system comprising an inspiratory limb (200, 650) and an expiratory limb (202, 652); an aerosolization device (100, 600), comprising: an aerosol chamber (102, 602) having a first end and a second end; an aerosol generator (112, 612) positioned at the first end of the aerosol chamber (102, 602), wherein: the aerosol generator (112, 612) comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator (112, 612); and the aerosol generator (112, 612) is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min; a patient interface that is positioned proximate the second end of the aerosol chamber (102, 602); and a respiratory adaptor (106, 606) that is configured to couple the aerosolization system with the respiration system; an aerosol chamber (102, 602) having a first end and a second end; an aerosol generator (112, 612) positioned at the first end of the aerosol chamber (102, 602), wherein: the aerosol generator (112, 612) comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator (112, 612); and the aerosol generator (112, 612) is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min; the aerosol generator (112, 612) comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator (112, 612); and the aerosol generator (112, 612) is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min; a patient interface that is positioned proximate the second end of the aerosol chamber (102, 602); and a respiratory adaptor (106, 606) that is configured to couple the aerosolization system with the respiration system; at least one breath sensor that is configured to detect an inhalation of a patient; and a controller (1702, 1706) that is configured to actuate the aerosol generator to aerosolize the volume of medicament in synchronization with the detected inhalation; characterized in that: the respiratory adaptor (106, 606) comprises a diversion mechanism that is configured to divert a portion of airflow from the respiration system into the aerosol chamber via at least one airway; and the aerosol chamber (102, 602) is configured to mix the portion of the airflow with aerosolized medicament from the aerosol generator; the diversion mechanism comprises at least one baffle (622, 626) that defines the at least one airway; and the at least one baffle (622, 626) is configured to divert the portion of airflow into the aerosol chamber via the at least one airway and to divert an additional portion of airflow from the inspiratory limb to the expiratory limb. the respiratory adaptor (106, 606) comprises a diversion mechanism that is configured to divert a portion of airflow from the respiration system into the aerosol chamber via at least one airway; and the aerosol chamber (102, 602) is configured to mix the portion of the airflow with aerosolized medicament from the aerosol generator; the diversion mechanism comprises at least one baffle (622, 626) that defines the at least one airway; and the at least one baffle (622, 626) is configured to divert the portion of airflow into the aerosol chamber via the at least one airway and to divert an additional portion of airflow from the inspiratory limb to the expiratory limb.