A crossflow membrane separation system comprising: a membrane vessel housing a membrane element, wherein the membrane vessel has a vertical orientation; a vessel retentate inlet that provides a retentate from a vessel feed line directly into a retentate side of the vertically oriented membrane vessel, wherein the retentate side is a top portion of the membrane vessel, wherein the vessel feed line receives the retentate from a pump and comprises a raw product and infeed valve, an air-blow valve, fluidly connected to an air shutoff valve, and a line block valve; a back pressure control valve adjusted to remove permeate from the retentate to a permeate side of the vertically oriented vessel through the membrane element; a vessel retentate outlet associated with a retentate outlet valve and a vessel permeate outlet associated with a permeate outlet valve, each removing the retentate and the permeate from the vessel, respectively; and a permeate side air inlet configured on a top end of the vertically oriented vessel that receives air from a permeate air control valve, wherein permeate and retentate air inlets are configured to supply air that scavenges remaining retentate, permeate or chemical residues from the membrane element, and further wherein the permeate side air inlet and the retentate air inlet are each configured to provide air pressure to the vessel such that a pressure in the retentate side is continuously greater than or equal to a pressure on the permeate side, wherein the retentate side air inlet receives air from the vessel feed line, and the permeate side air inlet is downstream of the retentate side air inlet, and is fluidly connected to it by the permeate air control valve. a membrane vessel housing a membrane element, wherein the membrane vessel has a vertical orientation; a vessel retentate inlet that provides a retentate from a vessel feed line directly into a retentate side of the vertically oriented membrane vessel, wherein the retentate side is a top portion of the membrane vessel, wherein the vessel feed line receives the retentate from a pump and comprises a raw product and infeed valve, an air-blow valve, fluidly connected to an air shutoff valve, and a line block valve; a back pressure control valve adjusted to remove permeate from the retentate to a permeate side of the vertically oriented vessel through the membrane element; a vessel retentate outlet associated with a retentate outlet valve and a vessel permeate outlet associated with a permeate outlet valve, each removing the retentate and the permeate from the vessel, respectively; and a permeate side air inlet configured on a top end of the vertically oriented vessel that receives air from a permeate air control valve, wherein permeate and retentate air inlets are configured to supply air that scavenges remaining retentate, permeate or chemical residues from the membrane element, and further wherein the permeate side air inlet and the retentate air inlet are each configured to provide air pressure to the vessel such that a pressure in the retentate side is continuously greater than or equal to a pressure on the permeate side, wherein the retentate side air inlet receives air from the vessel feed line, and the permeate side air inlet is downstream of the retentate side air inlet, and is fluidly connected to it by the permeate air control valve.