A drug delivery device with a dose setting mechanism, said mechanism comprising: a drug delivery device housing; a dose dial sleeve positioned at least partly in the housing and is rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery; and a clutch nut that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut, characterized in that the clutch nut is fixed to the dose dial sleeve from a dose of 0 to a predetermined minimum dose by means of interacting splines or by means of a one-directional coupling (11, 17') or ratchet, wherein the threaded interface between the clutch nut and the clutch is adapted such that the rotation of the clutch, which rotates with dose dial sleeve during dose setting, causes the clutch nut to travel axially in the distal direction from the dose dial sleeve, and when the dose dial sleeve and the clutch have been wound out during dose setting to the predetermined minimum dose threshold, the clutch nut will have advanced axially in the distal direction sufficiently along the clutch to allow axial separation of the clutch nut from the dose dial sleeve, and/or the clutch nut is fixed to the dose dial sleeve from a dose above a predetermined maximum dose by means of interacting splines or by means of a one-directional coupling (11, 17') or ratchet, wherein the threaded interface between the clutch nut and the clutch is adapted such that the clutch nut is out of engagement with the dose dial sleeve and travels axially in the proximal direction during dose setting before a predetermined maximum dose is reached, and when the maximum dose is reached, the clutch nut and the dose dial sleeve engage with each other. a drug delivery device housing; a dose dial sleeve positioned at least partly in the housing and is rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery; and a clutch nut that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut, characterized in that the clutch nut is fixed to the dose dial sleeve from a dose of 0 to a predetermined minimum dose by means of interacting splines or by means of a one-directional coupling (11, 17') or ratchet, wherein the threaded interface between the clutch nut and the clutch is adapted such that the rotation of the clutch, which rotates with dose dial sleeve during dose setting, causes the clutch nut to travel axially in the distal direction from the dose dial sleeve, and when the dose dial sleeve and the clutch have been wound out during dose setting to the predetermined minimum dose threshold, the clutch nut will have advanced axially in the distal direction sufficiently along the clutch to allow axial separation of the clutch nut from the dose dial sleeve, and/or the clutch nut is fixed to the dose dial sleeve from a dose above a predetermined maximum dose by means of interacting splines or by means of a one-directional coupling (11, 17') or ratchet, wherein the threaded interface between the clutch nut and the clutch is adapted such that the clutch nut is out of engagement with the dose dial sleeve and travels axially in the proximal direction during dose setting before a predetermined maximum dose is reached, and when the maximum dose is reached, the clutch nut and the dose dial sleeve engage with each other.