A compound selected from the group consisting of a quinoline or quinazoline derivative of Formula, and a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof: wherein, Z is CH or N; X is C(=O); Y is hydrogen, -NR 6 R 7, -NR 6 C(=O)R 7, or -NR 6 C(=O)NR 6 R 7; n is an integer ranging from 0 to 3; R 1 is hydrogen, C 1-6 alkyl, C 1-6 alkanoyl, C 2-6 alkenoyl, or C 2-6 alkynoyl; R 2 is hydrogen or C 1-3 alkyl; R 3 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or C 3-6 alkynyloxyC 1-4 alkyl; R 4 and R 5 are each independently hydrogen, -O(CH 2) m -C 1-6 alkyl, -O(CH 2) m -C 3-6 cycloalkyl, -O(CH 2) m -C 3-6 heterocycloalkyl, -O(CH 2) m -C 5-10 aryl, -O(CH 2) m -C 5-10 heteroaryl or -O(CH 2) m -C 1-3 alkoxy, in which m is an integer ranging from 0 to 3; R 6 is hydrogen or C 1-6 alkyl; and R 7 is hydrogen, C 1-8 alkyl, -(CH 2) l -C 3-6 cycloalkyl, -(CH 2) l -C 3-6 heterocycloalkyl, -(CH 2) l -C 5-10 aryl or -(CH 2) l -C 5-10 heteroaryl, in which l is an integer ranging from 0 to 3; in which: said R 6 and R 7 are optionally linked together to form a ring structure; and said R 7 is optionally substituted with one or more substituents selected from the group consisting of halogen, -CF 3, -NO 2, -CN, C 1-8 alkyl, -(CH 2) p NR 8 R 9, -(CH 2) p OR 10, -(CH 2) p C(=O)R 11, -(CH 2) p C(=O)OR 10, -(CH 2) p C(=O)NR 8 R 9, -(CH 2) p NR 8 C(=O)R 11,-(CH 2) p SR 12, -(CH 2) p S(=O)R 11, -(CH 2) p S(=O) 2 R 11, and -(CH 2) p -C 3-6 cycloalkyl, -(CH 2) p -C 3-6 heterocycloalkyl, -(CH 2) p -C 5-10 aryl and -(CH 2) p -C 5-10 heteroaryl, in which p is an integer ranging from 0 to 3; in which: said R 8, R 9, R 10, R 11 and R 12 are each independently halogen, -CF 3, -NO 2, -CN, C 1-6 alkyl, -(CH 2) q -C 3-6 cycloalkyl, -(CH 2) q -C 3-6 heterocycloalkyl, -(CH 2) q -C 2-4 alkenyl,-(CH 2) q -C 2-4 alkynyl, -(CH 2) q -C 5-10 aryl or -(CH 2) q -C 5-10 heteroaryl, in which q is an integer ranging from 0 to 3; and said R 8 and R 9 are optionally linked together to form a ring structure. Z is CH or N; X is C(=O); Y is hydrogen, -NR 6 R 7, -NR 6 C(=O)R 7, or -NR 6 C(=O)NR 6 R 7; n is an integer ranging from 0 to 3; R 1 is hydrogen, C 1-6 alkyl, C 1-6 alkanoyl, C 2-6 alkenoyl, or C 2-6 alkynoyl; R 2 is hydrogen or C 1-3 alkyl; R 3 is hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or C 3-6 alkynyloxyC 1-4 alkyl; R 4 and R 5 are each independently hydrogen, -O(CH 2) m -C 1-6 alkyl, -O(CH 2) m -C 3-6 cycloalkyl, -O(CH 2) m -C 3-6 heterocycloalkyl, -O(CH 2) m -C 5-10 aryl, -O(CH 2) m -C 5-10 heteroaryl or -O(CH 2) m -C 1-3 alkoxy, in which m is an integer ranging from 0 to 3; R 6 is hydrogen or C 1-6 alkyl; and R 7 is hydrogen, C 1-8 alkyl, -(CH 2) l -C 3-6 cycloalkyl, -(CH 2) l -C 3-6 heterocycloalkyl, -(CH 2) l -C 5-10 aryl or -(CH 2) l -C 5-10 heteroaryl, in which l is an integer ranging from 0 to 3; in which: said R 6 and R 7 are optionally linked together to form a ring structure; and said R 7 is optionally substituted with one or more substituents selected from the group consisting of halogen, -CF 3, -NO 2, -CN, C 1-8 alkyl, -(CH 2) p NR 8 R 9, -(CH 2) p OR 10, -(CH 2) p C(=O)R 11, -(CH 2) p C(=O)OR 10, -(CH 2) p C(=O)NR 8 R 9, -(CH 2) p NR 8 C(=O)R 11,-(CH 2) p SR 12, -(CH 2) p S(=O)R 11, -(CH 2) p S(=O) 2 R 11, and -(CH 2) p -C 3-6 cycloalkyl, -(CH 2) p -C 3-6 heterocycloalkyl, -(CH 2) p -C 5-10 aryl and -(CH 2) p -C 5-10 heteroaryl, in which p is an integer ranging from 0 to 3; in which: said R 8, R 9, R 10, R 11 and R 12 are each independently halogen, -CF 3, -NO 2, -CN, C 1-6 alkyl, -(CH 2) q -C 3-6 cycloalkyl, -(CH 2) q -C 3-6 heterocycloalkyl, -(CH 2) q -C 2-4 alkenyl,-(CH 2) q -C 2-4 alkynyl, -(CH 2) q -C 5-10 aryl or -(CH 2) q -C 5-10 heteroaryl, in which q is an integer ranging from 0 to 3; and said R 8 and R 9 are optionally linked together to form a ring structure. said R 6 and R 7 are optionally linked together to form a ring structure; and said R 7 is optionally substituted with one or more substituents selected from the group consisting of halogen, -CF 3, -NO 2, -CN, C 1-8 alkyl, -(CH 2) p NR 8 R 9, -(CH 2) p OR 10, -(CH 2) p C(=O)R 11, -(CH 2) p C(=O)OR 10, -(CH 2) p C(=O)NR 8 R 9, -(CH 2) p NR 8 C(=O)R 11,-(CH 2) p SR 12, -(CH 2) p S(=O)R 11, -(CH 2) p S(=O) 2 R 11, and -(CH 2) p -C 3-6 cycloalkyl, -(CH 2) p -C 3-6 heterocycloalkyl, -(CH 2) p -C 5-10 aryl and -(CH 2) p -C 5-10 heteroaryl, in which p is an integer ranging from 0 to 3; in which: said R 8, R 9, R 10, R 11 and R 12 are each independently halogen, -CF 3, -NO 2, -CN, C 1-6 alkyl, -(CH 2) q -C 3-6 cycloalkyl, -(CH 2) q -C 3-6 heterocycloalkyl, -(CH 2) q -C 2-4 alkenyl,-(CH 2) q -C 2-4 alkynyl, -(CH 2) q -C 5-10 aryl or -(CH 2) q -C 5-10 heteroaryl, in which q is an integer ranging from 0 to 3; and said R 8 and R 9 are optionally linked together to form a ring structure. said R 8, R 9, R 10, R 11 and R 12 are each independently halogen, -CF 3, -NO 2, -CN, C 1-6 alkyl, -(CH 2) q -C 3-6 cycloalkyl, -(CH 2) q -C 3-6 heterocycloalkyl, -(CH 2) q -C 2-4 alkenyl,-(CH 2) q -C 2-4 alkynyl, -(CH 2) q -C 5-10 aryl or -(CH 2) q -C 5-10 heteroaryl, in which q is an integer ranging from 0 to 3; and said R 8 and R 9 are optionally linked together to form a ring structure.