A compound having the structure of Formula I A-B-Q-V Formula I wherein A is: B is -CH=CH-, -CH 2 -N(R 22)- or -CH 2 -CH 2 -, Q is -C - or -CH 2 -; V is or wherein b is 1 or 2 and a is 1 or 2; Y is NR 22, N-Q-U, CR 22 R 23, oxygen, S n, N-C -NR 22 R 23; N-(C=N-CN)-NR 22 R 23, N-(C=N-SO 2 CH 3)-NR 22 R 23, C=NOR 22, C=N-NR 22 R 23 or C-Q-U, n is 0, 1 or 2; U is NR 22 R 23, lower alkyl, haloalkyl, OR 22 or hydrogen; X is hydrogen, alkyl or -C≡CR 9; W is -OR 22, -NR 22 R 23, -N(R 22)-C -NR 22 R 23, -O-C -NR 22 R 23, -N(R 22)-C -NR 22 R 23, -O-C -NR 22 R 23, -S-C -NR 22 R 23, -N(R 22)-(C=N-CN)-NR 22 R 23, -N(R 22)-(C=N-SO 2 Me)-NR 22 R 23, or -C N(R 9)N(R 14)(R 16); wherein p is 0 or 1; R 14 and R 16 are each independently hydrogen, or -CH 3; R 1 and R 2 are independently -CH 3 or -CH 2 CH 3; R 3 is hydrogen, -CH 3 or -CH 2 CH 3; R a, and R b, are each independently hydrogen, deutero or -CH 3; R c, and R d, are each independently hydrogen, alkoxy, lower alkyl or alkenyl; R 9 is hydrogen, or -CH 3; R 22 and R 23 are each independently hydrogen; or lower alkyl; R 24 and R 25 are each independently hydrogen or -CH 3; R 26 is NR 22 R 23 or alkoxy; and wherein R 1 and R 2 taken together or R a and R b taken together along with the carbon to which they are attached are cyclopropyl; R 24 and R 25 taken together along with the carbon to which they are attached are cyclopropyl: R 24 and R 25 taken together is oxo; including pharmaceutically acceptable salts, solvates and hydrates thereof; and wherein lower alkyl is a branched or straigh chain acyclic alkyl group comprising one to ten carbon atoms; haloalkyl is a lower alkyl group, an alkenyl group, an alkynyl group, a bridged cycloalkyl group, a cycloalkyl group to which is appended one or more halogens; alkoxy is R 5o O-, wherein R 5o is an alkyl group; alkyl is an unbroken non-cyclic chain of carbon atoms that may be branched, unbranched, substituted with other chemical groups such as lower alkyl, hydroxyl, ester, amidyl, oxo, carboxyl, carboxamido, halo, cyano, nitrate, nitrite, thionitrate, thionitrite, sulfhydryl and amino, or unsubstituted; alkenyl is a branched or straight chain C 2 -C 10 hydrocarbon that can comprise one or more carbon-carbon double bonds; alkynyl is an unsaturated acyclic C 2 -C 10 hydrocarbon that can contain one or more carbon-carbon triple bonds; cycloalkyl is a saturated or unsaturated cyclic hydrocarbon comprising from 3 to 10 carbon atoms; heterocyclic ring is a saturated or unsaturated cyclic or polycyclic hydrocarbon group having 2 to 12 carbon atoms where 1 to 4 carbon atoms are replaced by one or more nitrogen, oxygen and/or sulfur atoms. A is: B is -CH=CH-, -CH 2 -N(R 22)- or -CH 2 -CH 2 -, Q is -C - or -CH 2 -; V is or wherein b is 1 or 2 and a is 1 or 2; Y is NR 22, N-Q-U, CR 22 R 23, oxygen, S n, N-C -NR 22 R 23; N-(C=N-CN)-NR 22 R 23, N-(C=N-SO 2 CH 3)-NR 22 R 23, C=NOR 22, C=N-NR 22 R 23 or C-Q-U, n is 0, 1 or 2; U is NR 22 R 23, lower alkyl, haloalkyl, OR 22 or hydrogen; X is hydrogen, alkyl or -C≡CR 9; W is -OR 22, -NR 22 R 23, -N(R 22)-C -NR 22 R 23, -O-C -NR 22 R 23, -N(R 22)-C -NR 22 R 23, -O-C -NR 22 R 23, -S-C -NR 22 R 23, -N(R 22)-(C=N-CN)-NR 22 R 23, -N(R 22)-(C=N-SO 2 Me)-NR 22 R 23, or -C N(R 9)N(R 14)(R 16); R 14 and R 16 are each independently hydrogen, or -CH 3; R 1 and R 2 are independently -CH 3 or -CH 2 CH 3; R 3 is hydrogen, -CH 3 or -CH 2 CH 3; R a, and R b, are each independently hydrogen, deutero or -CH 3; R c, and R d, are each independently hydrogen, alkoxy, lower alkyl or alkenyl; R 9 is hydrogen, or -CH 3; R 22 and R 23 are each independently hydrogen; or lower alkyl; R 24 and R 25 are each independently hydrogen or -CH 3; R 26 is NR 22 R 23 or alkoxy; and wherein R 1 and R 2 taken together or R a and R b taken together along with the carbon to which they are attached are cyclopropyl; R 24 and R 25 taken together along with the carbon to which they are attached are cyclopropyl: R 24 and R 25 taken together is oxo; including pharmaceutically acceptable salts, solvates and hydrates thereof; and wherein lower alkyl is a branched or straigh chain acyclic alkyl group comprising one to ten carbon atoms; haloalkyl is a lower alkyl group, an alkenyl group, an alkynyl group, a bridged cycloalkyl group, a cycloalkyl group to which is appended one or more halogens; alkoxy is R 5o O-, wherein R 5o is an alkyl group; alkyl is an unbroken non-cyclic chain of carbon atoms that may be branched, unbranched, substituted with other chemical groups such as lower alkyl, hydroxyl, ester, amidyl, oxo, carboxyl, carboxamido, halo, cyano, nitrate, nitrite, thionitrate, thionitrite, sulfhydryl and amino, or unsubstituted; alkenyl is a branched or straight chain C 2 -C 10 hydrocarbon that can comprise one or more carbon-carbon double bonds; alkynyl is an unsaturated acyclic C 2 -C 10 hydrocarbon that can contain one or more carbon-carbon triple bonds; cycloalkyl is a saturated or unsaturated cyclic hydrocarbon comprising from 3 to 10 carbon atoms; heterocyclic ring is a saturated or unsaturated cyclic or polycyclic hydrocarbon group having 2 to 12 carbon atoms where 1 to 4 carbon atoms are replaced by one or more nitrogen, oxygen and/or sulfur atoms.