A method performed by a remote radio unit, RRU, of a distributed base station system of a wireless communication network, the distributed base station system further comprising a base band unit, BBU, connected to the RRU, the RRU being connected to a plurality of antennas (121, 122, 123) through which the RRU wirelessly communicates signals with at least one user equipment, UE, (131, 132, 133), the signals comprising data to be communicated towards and from the at least one UE, the method comprising: receiving uplink signals from the at least one UE; determining a downlink channel estimate from the received uplink signals; determining a first part of precoding coefficients to be used for precoding signals to be sent downlink to the at least one UE based on the determined downlink channel estimate; sending information related to the received uplink signals to the BBU, said information being the actual uplink signal or a channel estimate H of the uplink signal or any information on which a channel estimate of the uplink signals can be determined, receiving a second part of the precoding coefficients from the BBU, the second part of the precoding coefficients being determined based on the sent information, precoding downlink signals of data received from the BBU using the first and the second part of the precoding coefficients, sending the precoded downlink signals to the at least one UE via the plurality of antennas, wherein the first part of the precoding coefficients is determined so as to spatially concentrate energy transmitted from the antennas in directions towards the UEs, and wherein the second part of the precoding coefficients is determined so as to pre-mitigate interference. receiving uplink signals from the at least one UE; determining a downlink channel estimate from the received uplink signals; determining a first part of precoding coefficients to be used for precoding signals to be sent downlink to the at least one UE based on the determined downlink channel estimate; sending information related to the received uplink signals to the BBU, said information being the actual uplink signal or a channel estimate H of the uplink signal or any information on which a channel estimate of the uplink signals can be determined, receiving a second part of the precoding coefficients from the BBU, the second part of the precoding coefficients being determined based on the sent information, precoding downlink signals of data received from the BBU using the first and the second part of the precoding coefficients, determining a downlink channel estimate from the received uplink signals; determining a first part of precoding coefficients to be used for precoding signals to be sent downlink to the at least one UE based on the determined downlink channel estimate; sending information related to the received uplink signals to the BBU, said information being the actual uplink signal or a channel estimate H of the uplink signal or any information on which a channel estimate of the uplink signals can be determined, receiving a second part of the precoding coefficients from the BBU, the second part of the precoding coefficients being determined based on the sent information, precoding downlink signals of data received from the BBU using the first and the second part of the precoding coefficients, sending the precoded downlink signals to the at least one UE via the plurality of antennas, wherein the first part of the precoding coefficients is determined so as to spatially concentrate energy transmitted from the antennas in directions towards the UEs, and wherein the second part of the precoding coefficients is determined so as to pre-mitigate interference.