A laser guidance system comprising at least two laser projection apparatuses (300, 300a, 300b, 31a, 31b) for projecting, directly onto an affected part, operation information of an insertion location and an insertion angle (α) planned by a user on a display device displaying a C-arm image photographed using a C-arm fluoroscopy device, the laser projection apparatuses each comprising: a line laser module comprising a green laser configured to generate a laser beam, a rotation line generator configured to transform the laser beam into a line laser by rotating the laser beam around an origin to form a plane, a rotating mirror configured to change a central rotation axis of the line laser, a first motor connected to the rotation line generator and configured to operate under the control of the control unit, and a second motor connected to the rotating mirror and configured to operate under the control of the control unit, a matching unit configured to calculate a coordinate representing the insertion location in a C-arm coordinate system based on the C-arm fluoroscopy image, to perform position matching between the C-arm fluoroscopy device and each laser projection apparatus (300, 300a, 300b, 31a, 31b), to calculate an insertional vector (Vtarget) according to the coordinate representing the insertion location and the insertion angle (α) input by the user; and a control unit configured to control the laser module, characterized in that the matching unit is further configured to calculate a vector (NormVL) perpendicular to the plane formed by the line laser (32a, 32b) in the C-arm coordinate system according to the insertional vector (Vtarget) from the user; and the control unit is further configured to control rotation angles (θ1, θ2) of the first motor and the second motor based on the vector (NormVL) perpendicular to the plane formed by the line laser projected to the affected part. a line laser module comprising a green laser configured to generate a laser beam, a rotation line generator configured to transform the laser beam into a line laser by rotating the laser beam around an origin to form a plane, a rotating mirror configured to change a central rotation axis of the line laser, a first motor connected to the rotation line generator and configured to operate under the control of the control unit, and a second motor connected to the rotating mirror and configured to operate under the control of the control unit, a matching unit configured to calculate a coordinate representing the insertion location in a C-arm coordinate system based on the C-arm fluoroscopy image, to perform position matching between the C-arm fluoroscopy device and each laser projection apparatus (300, 300a, 300b, 31a, 31b), to calculate an insertional vector (Vtarget) according to the coordinate representing the insertion location and the insertion angle (α) input by the user; and a control unit configured to control the laser module, characterized in that the matching unit is further configured to calculate a vector (NormVL) perpendicular to the plane formed by the line laser (32a, 32b) in the C-arm coordinate system according to the insertional vector (Vtarget) from the user; and the control unit is further configured to control rotation angles (θ1, θ2) of the first motor and the second motor based on the vector (NormVL) perpendicular to the plane formed by the line laser projected to the affected part.