An interface system for providing positive pressure respiratory therapy to users, the system comprising: a mask frame; and at least a first seal and a second seal that are interchangeably mountable to the mask frame, the first seal having a first size and the second seal having a second size different than the first size, each of the first seal and the second seal comprising: a seal body configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user, each seal comprising a nasal region comprising a nasal opening, each seal comprising a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region, the first paddle configured to contact and extend upward alongside one side of the nares of the user and the second paddle configured to contact and extend upward alongside the other side of the nares of the user, and each of the first seal and second seal comprising an oral opening; wherein each of the paddles of the first seal and the second seal comprises a support in the form of a suspension member, and the supports can extend along the upper edge of the paddles or the region or ridge that joins a laterally outer surface portion and a laterally inner surface portion along the upper edges of the paddles and each of the first seal and second seal is configured to accommodate a maximum nose breadth of the nose of the user that is determined by a maximum lateral distance between inner edges of the supports wherein a nasal opening-oral opening spacing linear distance between the nasal opening and the oral opening is between 10-15 mm. a mask frame; and at least a first seal and a second seal that are interchangeably mountable to the mask frame, the first seal having a first size and the second seal having a second size different than the first size, each of the first seal and the second seal comprising: a seal body configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user, each seal comprising a nasal region comprising a nasal opening, each seal comprising a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region, the first paddle configured to contact and extend upward alongside one side of the nares of the user and the second paddle configured to contact and extend upward alongside the other side of the nares of the user, and each of the first seal and second seal comprising an oral opening; wherein each of the paddles of the first seal and the second seal comprises a support in the form of a suspension member, and the supports can extend along the upper edge of the paddles or the region or ridge that joins a laterally outer surface portion and a laterally inner surface portion along the upper edges of the paddles and a seal body configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user, each seal comprising a nasal region comprising a nasal opening, each seal comprising a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region, the first paddle configured to contact and extend upward alongside one side of the nares of the user and the second paddle configured to contact and extend upward alongside the other side of the nares of the user, and each of the first seal and second seal comprising an oral opening; wherein each of the paddles of the first seal and the second seal comprises a support in the form of a suspension member, and the supports can extend along the upper edge of the paddles or the region or ridge that joins a laterally outer surface portion and a laterally inner surface portion along the upper edges of the paddles and each of the first seal and second seal is configured to accommodate a maximum nose breadth of the nose of the user that is determined by a maximum lateral distance between inner edges of the supports wherein a nasal opening-oral opening spacing linear distance between the nasal opening and the oral opening is between 10-15 mm.