A drive and dosing device for a medical injection device whereby a cartridge is attached or can be attached to the drive and dosing device comprising: a) a housing (4,18), b) a piston rod having a distal end, a proximal end and a thread and which is moveable in a dispensing direction with respect to the housing (4,18) for dispensing a product, c) a rotation member (13,15) which is rotationally secured connected to a stop limiter and which is engaged with the thread of the piston rod whereby a rotation of the rotation member (13,15) relative to the piston rod in a second direction ensures that the piston rod with its distal end ahead is moved relative to the housing (4,18) in the dispensing direction, d) a unidirectional coupling (71,72,73,74) that exists between the housing (4,18) and the rotation member (13,15) which allows for a rotation of the rotation member (13,15) in the second direction direction, and which prevents a rotation in a first direction, opposite to the second direction, e) a dose knob which is rotatable in the first direction relative to the housing (4,18) and/or piston rod for increasing a dose that can be dispensed from the cartridge, characterized by f) a stop element with a catch and a thread engaging the thread of the piston rod whereby the dose knob is coupled with the stop element such that a rotation of the dose knob relative to the piston rod in the first direction results in a rotation of the stop element relative to the piston rod whereby the stop element is screwed towards the distal end of the piston rod and the catch is moved towards the stop limiter, g) whereby the stop element prevents setting a dose or the rotation of the dose knob in the first direction when the catch abuts the stop limiter. a) a housing (4,18), b) a piston rod having a distal end, a proximal end and a thread and which is moveable in a dispensing direction with respect to the housing (4,18) for dispensing a product, c) a rotation member (13,15) which is rotationally secured connected to a stop limiter and which is engaged with the thread of the piston rod whereby a rotation of the rotation member (13,15) relative to the piston rod in a second direction ensures that the piston rod with its distal end ahead is moved relative to the housing (4,18) in the dispensing direction, d) a unidirectional coupling (71,72,73,74) that exists between the housing (4,18) and the rotation member (13,15) which allows for a rotation of the rotation member (13,15) in the second direction direction, and which prevents a rotation in a first direction, opposite to the second direction, e) a dose knob which is rotatable in the first direction relative to the housing (4,18) and/or piston rod for increasing a dose that can be dispensed from the cartridge, characterized by f) a stop element with a catch and a thread engaging the thread of the piston rod whereby the dose knob is coupled with the stop element such that a rotation of the dose knob relative to the piston rod in the first direction results in a rotation of the stop element relative to the piston rod whereby the stop element is screwed towards the distal end of the piston rod and the catch is moved towards the stop limiter, g) whereby the stop element prevents setting a dose or the rotation of the dose knob in the first direction when the catch abuts the stop limiter.