mhurhangee/ep-ind-claims huggingface dataset:
Non-spherical granules of microcrystalline mannitol, characterized: - in that said mannitol is both in α crystalline form and in β crystalline form, the α/β ratio being between 10/90 and 90/10; and - in that they are essentially free of granular starch; and - in that they have a volume mean diameter D4,3 of from 60 to 250 μm; and - in that they have a bulk density of at least 465 g/l; and - in that they have a specific surface area greater than 0.75 m 2 /g. - in that said mannitol is both in α crystalline form and in β crystalline form, the α/β ratio being between 10/90 and 90/10; and - in that they are essentially free of granular starch; and - in that they have a volume mean diameter D4,3 of from 60 to 250 μm; and - in that they have a bulk density of at least 465 g/l; and - in that they have a specific surface area greater than 0.75 m 2 /g.
A system for use with an oilfield device (3010, 4002, 3122, 3310, 3410) arranged to be latched with a housing (3080, 4070, 3110, 3200, 3320, 3420), the system comprising: a latch assembly (3020, 4000, 3100, 3300, 3400) positioned with, and attached to, the housing and latchable to the oilfield device, the latch assembly comprising: a retainer member (3040, 4004, 3120, 3350, 3430) movable between an unlatched position and a latched position, the retainer member latched with the oilfield device in the latched position; and a piston (3050, 4022, 3130, 3340, 3440) moveable between a latched position and an unlatched position, the piston being arranged to move the retainer member to the latched position and the piston allowing the retainer member to move to the unlatched position; the system further comprising: a latch position indicator system positioned with the latch assembly or the housing to indicate, at a remote location, the position of the piston, characterised in that said latch position indicator system is non-contact. a latch assembly (3020, 4000, 3100, 3300, 3400) positioned with, and attached to, the housing and latchable to the oilfield device, the latch assembly comprising: a retainer member (3040, 4004, 3120, 3350, 3430) movable between an unlatched position and a latched position, the retainer member latched with the oilfield device in the latched position; and a piston (3050, 4022, 3130, 3340, 3440) moveable between a latched position and an unlatched position, the piston being arranged to move the retainer member to the latched position and the piston allowing the retainer member to move to the unlatched position; the system further comprising: a latch position indicator system positioned with the latch assembly or the housing to indicate, at a remote location, the position of the piston, characterised in that said latch position indicator system is non-contact. a retainer member (3040, 4004, 3120, 3350, 3430) movable between an unlatched position and a latched position, the retainer member latched with the oilfield device in the latched position; and a piston (3050, 4022, 3130, 3340, 3440) moveable between a latched position and an unlatched position, the piston being arranged to move the retainer member to the latched position and the piston allowing the retainer member to move to the unlatched position; the system further comprising: a latch position indicator system positioned with the latch assembly or the housing to indicate, at a remote location, the position of the piston, characterised in that said latch position indicator system is non-contact. a latch position indicator system positioned with the latch assembly or the housing to indicate, at a remote location, the position of the piston, characterised in that said latch position indicator system is non-contact.
A welding or additive manufacturing wire drive system, comprising: a first drive roll having a first annular groove; a second drive roll having a second annular groove aligned with the first annular groove; a first and a second welding wire (E1, E2); characterized by: the first welding wire located between the first drive roll and the second drive roll in both of the first annular groove and the second annular groove; the second welding wire located between the first drive roll and the second drive roll in both of the first annular groove and the second annular groove; and a biasing member that biases the first drive roll toward the second drive roll to force the first welding wire to contact the second welding wire, wherein: the first welding wire contacts each of a first sidewall portion of the first annular groove, a first sidewall portion of the second annular groove, and the second welding wire, the second welding wire contacts each of a second sidewall portion of the first annular groove, a second sidewall portion of the second annular groove, and the first welding wire, and the first drive roll and the second drive roll rotate in opposite directions thereby moving the first welding wire and the second welding wire through the wire drive system. a first drive roll having a first annular groove; a second drive roll having a second annular groove aligned with the first annular groove; a first and a second welding wire (E1, E2); the first welding wire located between the first drive roll and the second drive roll in both of the first annular groove and the second annular groove; the second welding wire located between the first drive roll and the second drive roll in both of the first annular groove and the second annular groove; and a biasing member that biases the first drive roll toward the second drive roll to force the first welding wire to contact the second welding wire, wherein: the first welding wire contacts each of a first sidewall portion of the first annular groove, a first sidewall portion of the second annular groove, and the second welding wire, the second welding wire contacts each of a second sidewall portion of the first annular groove, a second sidewall portion of the second annular groove, and the first welding wire, and the first drive roll and the second drive roll rotate in opposite directions thereby moving the first welding wire and the second welding wire through the wire drive system. the first welding wire contacts each of a first sidewall portion of the first annular groove, a first sidewall portion of the second annular groove, and the second welding wire, the second welding wire contacts each of a second sidewall portion of the first annular groove, a second sidewall portion of the second annular groove, and the first welding wire, and the first drive roll and the second drive roll rotate in opposite directions thereby moving the first welding wire and the second welding wire through the wire drive system.
A blow molded article selected from a canister, jerry can, cask, tank, drum or barrel, made from or comprising a trimodal polyethylene having a density of from 0.950 to 0.958 g/cm 3, preferably of from 0.952 to 0.956 g/cm 3, produced by polymerisation with a Ziegler catalyst, wherein the canister and jerry can are of 15 to 60 L volume and are made from or comprise the said trimodal polyethylene with a melt index (HLMI) according to ASTM D-1238, at 190°C and 21.6 kg, in the range of from 4 to 7 g/10 min and a dimensionless Hostalene Index (HLCBI) value of from 7 to 10, and the cask, tank, drum and barrel are of 90 to 150 L volume and are made from or comprise the said trimodal polyethylene with a melt index HLMI in the range of from 2.5 to 5.5 g/10 min and a HLCBI value of from 9.5 to 14.5.
A small molecule CBP/catenin antagonist compound selected from: (a) wherein n=0 to 34; preferably, wherein the small molecule CBP/catenin antagonist compound is: or (b) wherein R 1 is selected from C1-C6 alkyl; and wherein n=0 to 34; preferably, wherein R 1 is CH 3; and wherein n=10; or, (c): wherein R 1 is selected from C1-C6 alkyl; and wherein n=0 to 34; preferably, wherein R 1 is CH 3 and wherein n=10. (a) wherein n=0 to 34; preferably, wherein the small molecule CBP/catenin antagonist compound is: or (b) wherein R 1 is selected from C1-C6 alkyl; and wherein n=0 to 34; preferably, wherein R 1 is CH 3; and wherein n=10; or, wherein R 1 is selected from C1-C6 alkyl; and wherein n=0 to 34; preferably, wherein R 1 is CH 3; and wherein n=10; or, (c): wherein R 1 is selected from C1-C6 alkyl; and wherein n=0 to 34; preferably, wherein R 1 is CH 3 and wherein n=10.
A heterocycle-containing amino acid compound represented by a formula: wherein R 1, R 2 and R 3 are identical with or different from each other, and represent a hydrogen atom or a carboxyl-protecting group selected from C 1-6 linear, branched or cyclic alkyl group, benzyl group, p-nitrobenzyl group, o-nitrobenzyl group, m-nitrobenzyl group, 2,4-dinitrobenzyl group, p-chlorobenzyl group, p-bromobenzyl group, p-methoxybenzyl group, acetoxymethyl group, acetoxyethyl group, propionyloxymethyl group, n-butyryloxymethyl group, iso-butyryloxymethyl group, and pivaloyloxymethyl group; R 4 represents a hydrogen atom or a hydroxyl-protecting group selected from C 1-6 linear or branched alkyl group, benzyl group, p-nitrobenzyl group, o-nitrobenzyl group, m-nitrobenzyl group, 2,4-dinitrobenzyl group, p-chlorobenzyl group, p-bromobenzyl group, p-methoxybenzyl group, trialkylsilyl group, tetrahydropyran-2-yl group, methoxymethyl group, methoxyethoxymethyl group, and alkoxycarbonyl group; R 5 represents a hydrogen atom or an amino-protecting group selected from methoxycarbonyl group, ethoxycarbonyl group, 2,2,2-trichloroethoxycarbonyl group, tert-butoxycarbonyl group, alkenyloxycarbonyl group, aralkyloxycarbonyl group, benzyl group, p-nitrobenzyl group, o-nitrobenzyl group, m-nitrobenzyl group, 2,4-dinitrobenzyl group, p-chlorobenzyl group, p-bromobenzyl group, p-methoxybenzyl group, acyl group, arylsulfonyl group, and alkylsulfonyl group; and n represents an integer of 1 or 2, or a salt thereof.
A vaginal endoscopic port unit module for laparoscopic surgery, which is configured to be positioned at one end thereof inside the human body and at the other end thereof outside the human body through a vaginal orifice, the module comprising: an outer unit whose end is disposed so as to be exposed to the outside of the vaginal orifice and which includes at least one outer port configured to permit entry of a surgical instrument including an endoscope; an inner unit configured to be disposed at an incision site formed on the inner wall of the vaginal canal so as to fluidically communicate with the abdominal cavity, and include an inner port permitting introduction and withdrawal of the surgical instrument introduced thereto through the at least one outer port into and from the abdominal cavity (3; and a runner unit that connects the outer unit to the inner unit, characterized in the inner unit comprising an inner unit header having a diffuser structure that is configured to be widened after the insertion thereof into the incision site formed on the inner wall of the vaginal canal; and in that an inner shape of the inner port has a diffuser structure at the end (311b, 311c) of the inner unit header that is configured to be introduced into the abdominal cavity. an outer unit whose end is disposed so as to be exposed to the outside of the vaginal orifice and which includes at least one outer port configured to permit entry of a surgical instrument including an endoscope; an inner unit configured to be disposed at an incision site formed on the inner wall of the vaginal canal so as to fluidically communicate with the abdominal cavity, and include an inner port permitting introduction and withdrawal of the surgical instrument introduced thereto through the at least one outer port into and from the abdominal cavity (3; and a runner unit that connects the outer unit to the inner unit, characterized in the inner unit comprising an inner unit header having a diffuser structure that is configured to be widened after the insertion thereof into the incision site formed on the inner wall of the vaginal canal; and in that an inner shape of the inner port has a diffuser structure at the end (311b, 311c) of the inner unit header that is configured to be introduced into the abdominal cavity.
A microRNA selected from the group consisting of: UAAUUUUAUGUAUAAGCUAGU (SEQ ID NO: 29), ACAGUAGUCUGCACAUUGGUUA (SEQ ID NO: 14), ACUGCCCUAAGUGCUCCUUCUGG (SEQ ID NO: 1), CAGUGCCUCGGCAGUGCAGCCC (SEQ ID NO: 10), ACCUUCUUGUAUAAGCACUGUGCUAAA (SEQ ID NO: 33), and UCCAGUGCCCUCCUCUCC (SEQ ID NO: 35), or a primary transcript for such microRNA, or a precursor of such microRNA, or a mimic of such microRNA or a combination thereof for use as a medicament for stimulating heart regeneration through cardiac myocyte proliferation. UAAUUUUAUGUAUAAGCUAGU (SEQ ID NO: 29), ACAGUAGUCUGCACAUUGGUUA (SEQ ID NO: 14), ACUGCCCUAAGUGCUCCUUCUGG (SEQ ID NO: 1), CAGUGCCUCGGCAGUGCAGCCC (SEQ ID NO: 10), ACCUUCUUGUAUAAGCACUGUGCUAAA (SEQ ID NO: 33), and UCCAGUGCCCUCCUCUCC (SEQ ID NO: 35),
Satellite propelled by laser ablation comprising: - a device for managing the attitude and the orbit of the satellite; - a device for external communication; - a laser ablation propulsion device comprising one or more lasers and a module for managing the one or more lasers; characterized in that the satellite comprises: a device for capturing and potentially for processing a target spaceborne body; a device for visually inspecting the target spaceborne body; and in that the module for managing the one or more lasers is suitable for determining the one or more laser beams to be generated on the captured target spaceborne body according to the movement desired for the satellite. - a device for managing the attitude and the orbit of the satellite; - a device for external communication; - a laser ablation propulsion device comprising one or more lasers and a module for managing the one or more lasers; a device for capturing and potentially for processing a target spaceborne body; a device for visually inspecting the target spaceborne body; and in that the module for managing the one or more lasers is suitable for determining the one or more laser beams to be generated on the captured target spaceborne body according to the movement desired for the satellite.
A rechargeable sodium battery comprising: a negative electrode comprising metallic sodium in molten state; a positive electrode comprising a mixture of NaX and M; wherein X is a halogen selected from Cl, Br and I and M is a metal selected Ni, Fe, and Zn; wherein the positive electrode is disposed in a mixed molten salt positive electrolyte comprising at least two salts that can be represented by the formula NaAlX' 4-δ X" δ, where 0 < δ < 4; wherein X' and X" are different halogens selected from Cl, Br and I; and wherein the positive electrolyte comprises additional NaX or a mixture of NaX compounds; and a sodium ion conductive solid electrolyte provided between the negative electrode and the positive electrode; wherein the additional NaX or a mixture of NaX compounds are added to the positive electrolyte in a molar ratio to the mixed molten salt positive electrolyte ranging from 1:1 to 3:1 of NaX: NaAlX' 4-δ X" δ. a negative electrode comprising metallic sodium in molten state; a positive electrode comprising a mixture of NaX and M; wherein X is a halogen selected from Cl, Br and I and M is a metal selected Ni, Fe, and Zn; wherein the positive electrode is disposed in a mixed molten salt positive electrolyte comprising at least two salts that can be represented by the formula NaAlX' 4-δ X" δ, where 0 < δ < 4; wherein X' and X" are different halogens selected from Cl, Br and I; and wherein the positive electrolyte comprises additional NaX or a mixture of NaX compounds; and a sodium ion conductive solid electrolyte provided between the negative electrode and the positive electrode; wherein the additional NaX or a mixture of NaX compounds are added to the positive electrolyte in a molar ratio to the mixed molten salt positive electrolyte ranging from 1:1 to 3:1 of NaX: NaAlX' 4-δ X" δ.
A three-phase hybrid type stepping motor comprising a stator, and a rotor arranged concentrically with the stator and with an air gap therebetween, said stator having an annular stator yoke, six stator poles extending radially and formed at a regular pitch on the inner peripheral surface of the annular stator yoke, and stator windings of three-phase each wound around each stator pole, each of said stator poles having a plurality of small stator teeth at the tip end thereof, said rotor having two splitted rotor elements and a permanent magnet held therebetween and magnetized so as to form N and S poles in the axial direction thereof, and a plurality of small rotor teeth formed at a regular pitch on the outer peripheral surface of each of said rotor elements, said two splitted rotor elements being shifted from each other in angular position by a 1/2 pitch of the small rotor teeth, a permeance distribution of the small stator teeth is a vernier pitch balanced by a six order harmonic wave, and a tooth width ratio of the small rotor teeth with the small stator teeth is set to 0.35 - 0-45.
A switch cabinet which has a plurality of vertical frame profiles by which outer vertical planes are defined, at least one sidewall of the switch cabinet being arranged in at least one of the vertical planes, the sidewall consisting at least partially of a textile with metallic or metallically coated threads or fibres (4.1), the switch cabinet having a roof element, on the upper side of which the sidewall is fixed via an upper retaining clip, an EMI shielding seal being arranged along an outer edge of the roof element, on the upper side of the roof element, between the textile and the roof element, characterised in that the EMI shielding seal is arranged between the outer edge of the roof element and the retaining clip, the textile being braced under compression of the EMI shielding seal by displacement of the upper retaining clip, the compression of the seal being varied by variation of the bracing.
A vehicle lamp having a structure in which a lower substrate, a fluorescent film and a color filter are stacked in this order, wherein the fluorescent film and the color filter comprise polydimethylsiloxane (PDMS).
A computer-implemented method of analysing genetic data comprising: receiving a polygenic risk score for a target phenotype or target phenotype combination for a target individual; receiving individual genetic data for the target individual, the individual genetic data informative about an ancestry of the target individual; determining an individual position in an ancestry space using the individual genetic data, the individual position represented by a combination of continuous or pseudo-continuous variables, or the individual position comprising an assignment to a weighted combination of a plurality of ancestries; and calculating a genetic contribution to a risk for the target individual for the target phenotype or target phenotype combination using the polygenic risk score and the individual position, the genetic contribution to the risk having a continuous or pseudo-continuous dependency on the individual position, wherein the ancestry space is defined using reference genetic data from a plurality of reference individuals having a plurality of different ancestries. receiving a polygenic risk score for a target phenotype or target phenotype combination for a target individual; receiving individual genetic data for the target individual, the individual genetic data informative about an ancestry of the target individual; determining an individual position in an ancestry space using the individual genetic data, the individual position represented by a combination of continuous or pseudo-continuous variables, or the individual position comprising an assignment to a weighted combination of a plurality of ancestries; and calculating a genetic contribution to a risk for the target individual for the target phenotype or target phenotype combination using the polygenic risk score and the individual position, the genetic contribution to the risk having a continuous or pseudo-continuous dependency on the individual position, wherein the ancestry space is defined using reference genetic data from a plurality of reference individuals having a plurality of different ancestries.
A method comprising: deforming an organic polymer composition at a temperature below a glass transition temperature of an organic polymer in the organic polymer composition; the deforming being conducted by an application of a shear force, an elongational force, a compressive force, or a combination comprising at least one of the foregoing forces; the forces being applied to the organic polymer composition as it is disposed between a first roll that comprises a rubber surface and a second roll that comprises a textured metal surface; the deforming producing a textured film having a ratio of texturing of about 0.5 to about 3; the textured film having a thickness of about 5 to about 75 micrometers and an average roughness of about 0.3 to about 6 micrometers on opposing surfaces of the film. deforming an organic polymer composition at a temperature below a glass transition temperature of an organic polymer in the organic polymer composition; the deforming being conducted by an application of a shear force, an elongational force, a compressive force, or a combination comprising at least one of the foregoing forces; the forces being applied to the organic polymer composition as it is disposed between a first roll that comprises a rubber surface and a second roll that comprises a textured metal surface; the deforming producing a textured film having a ratio of texturing of about 0.5 to about 3; the textured film having a thickness of about 5 to about 75 micrometers and an average roughness of about 0.3 to about 6 micrometers on opposing surfaces of the film.
Transdermal therapeutic system for the transdermal administration of asenapine comprising a self-adhesive layer structure comprising a therapeutically effective amount of asenapine, said self-adhesive layer structure comprising: A) a backing layer; B) an asenapine-containing layer comprising: 1. asenapine in the form of the free base; and 2. a polymer selected from the group consisting of polysiloxanes and polyisobutylenes in an amount of more than 50 % by weight based on the total weight of the asenapine-containing layer; and C) optionally an additional skin contact layer; wherein the asenapine-containing layer comprises a crystallization inhibitor being polyvinylpyrrolidone in an amount of 0.5 to 10 % by weight based on the total weight of the asenapine-containing layer. A) a backing layer; B) an asenapine-containing layer comprising: 1. asenapine in the form of the free base; and 2. a polymer selected from the group consisting of polysiloxanes and polyisobutylenes in an amount of more than 50 % by weight based on the total weight of the asenapine-containing layer; and 1. asenapine in the form of the free base; and 2. a polymer selected from the group consisting of polysiloxanes and polyisobutylenes in an amount of more than 50 % by weight based on the total weight of the asenapine-containing layer; C) optionally an additional skin contact layer;