A compound of Formula: or a pharmaceutically acceptable salt, solvate, or N-oxide thereof; wherein: Het is a heterocyclic ring selected from: wherein A and B are each independently selected from N or C-R 4, provided that at least one of A and B is C-R 4; Each R 1 and R 2 are independently selected from hydrogen; halogen; C 1-6 alkyl, straight or branched, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; C 1-3 alkoxy, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; -O-C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; -S-C 1-3 alkyl, optionally substituted with at least one halogen atom; -SO 2 -C 1-3 alkyl, optionally substituted with at least one halogen atom; and -SF 5; or R 1 and R 2 together form a 5 to 7 member carbocycle, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; or a 5 to 7 member heterocycle containing one to three heteroatoms selected from O, S or N, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; R 3 is selected from hydrogen; C 1-5 alkyl, optionally substituted with at least one substituent, selected from halogen, hydroxy, C 1-3 (halo)alkoxy, and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent, selected from hydroxy, halogen, C 1-3 (halo)alkyl, and C 1-3 (halo)alkoxy; -O-C 3-6 cycloalkyl, optionally substituted with at least one substituent, selected from hydroxy, halogen, C 1-3 (halo)alkyl, and C 1-3 (halo)alkoxy; and each R 4 and R 5 group is independently selected from hydrogen; amino; halogen; C 1-5 alkyl, optionally substituted with at least one substituent selected from halogen, hydroxy, C 1-3 (halo)alkoxy, and C 3-6 (halo)cycloalkyl; C 1-5 alkoxy, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; and -O-C 3-6 cycloalkyl optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy. A and B are each independently selected from N or C-R 4, provided that at least one of A and B is C-R 4; Each R 1 and R 2 are independently selected from hydrogen; halogen; C 1-6 alkyl, straight or branched, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; C 1-3 alkoxy, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; -O-C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; -S-C 1-3 alkyl, optionally substituted with at least one halogen atom; -SO 2 -C 1-3 alkyl, optionally substituted with at least one halogen atom; and -SF 5; or R 1 and R 2 together form a 5 to 7 member carbocycle, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; or a 5 to 7 member heterocycle containing one to three heteroatoms selected from O, S or N, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; R 3 is selected from hydrogen; C 1-5 alkyl, optionally substituted with at least one substituent, selected from halogen, hydroxy, C 1-3 (halo)alkoxy, and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent, selected from hydroxy, halogen, C 1-3 (halo)alkyl, and C 1-3 (halo)alkoxy; -O-C 3-6 cycloalkyl, optionally substituted with at least one substituent, selected from hydroxy, halogen, C 1-3 (halo)alkyl, and C 1-3 (halo)alkoxy; and each R 4 and R 5 group is independently selected from hydrogen; amino; halogen; C 1-5 alkyl, optionally substituted with at least one substituent selected from halogen, hydroxy, C 1-3 (halo)alkoxy, and C 3-6 (halo)cycloalkyl; C 1-5 alkoxy, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkoxy and C 3-6 (halo)cycloalkyl; C 3-6 cycloalkyl, optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy; and -O-C 3-6 cycloalkyl optionally substituted with at least one substituent selected from hydroxy, halogen, C 1-3 (halo)alkyl and C 1-3 (halo)alkoxy.