mhurhangee/ep-ind-claims huggingface dataset:
An isolated or purified T-cell receptor comprising the alpha chain complementarity determining region 1 amino acid sequence of SEQ ID NO: 3, the alpha chain CDR2 amino acid sequence of SEQ ID NO: 4, the alpha chain CDR3 amino acid sequence of SEQ ID NO: 5, the beta chain CDR1 amino acid sequence of SEQ ID NO: 6, the beta chain CDR2 amino acid sequence of SEQ ID NO: 7, and the beta chain CDR3 amino acid sequence of SEQ ID NO: 8, and having antigenic specificity for NY-ESO-1 (SEQ ID NO: 1), preferably wherein the TCR: (a) has antigenic specificity for NY-ESO-1 157-165 (SEQ ID NO: 2); (b) comprises the amino acid sequences of SEQ ID NOs: 9 and 10; and/or (c) comprises the amino acid sequences of SEQ ID NOs: 11 and 12. (a) has antigenic specificity for NY-ESO-1 157-165 (SEQ ID NO: 2); (b) comprises the amino acid sequences of SEQ ID NOs: 9 and 10; and/or (c) comprises the amino acid sequences of SEQ ID NOs: 11 and 12.
A ball screw spline assembly, comprising: a ball screw spline including a first nut including a first mounting surface adapted to receive a first fastening element for installing the first nut to a housing, the first fastening element being received by the first mounting surface of the first nut; a second nut including a second mounting surface adapted to receive a second fastening element for installing the second nut to the housing, the second fastening element being received by the second mounting surface of the second nut; and a shaft passing through the first nut and the second nut; the housing including a first portion and a second portion, wherein the first portion extends in a direction substantially parallel to the shaft, and the second portion extends in a direction substantially perpendicular to the shaft; a connecting plate coupling the second nut to the first portion, wherein the first nut is installed to the second portion with the first fastening element; wherein the first mounting surface and the second mounting surface are located within a space defined by the first portion, the second portion and the connecting plate, such that the ball screw spline is integrally installable to the housing. a ball screw spline including a first nut including a first mounting surface adapted to receive a first fastening element for installing the first nut to a housing, the first fastening element being received by the first mounting surface of the first nut; a second nut including a second mounting surface adapted to receive a second fastening element for installing the second nut to the housing, the second fastening element being received by the second mounting surface of the second nut; and a shaft passing through the first nut and the second nut; a first nut including a first mounting surface adapted to receive a first fastening element for installing the first nut to a housing, the first fastening element being received by the first mounting surface of the first nut; a second nut including a second mounting surface adapted to receive a second fastening element for installing the second nut to the housing, the second fastening element being received by the second mounting surface of the second nut; and a shaft passing through the first nut and the second nut; the housing including a first portion and a second portion, wherein the first portion extends in a direction substantially parallel to the shaft, and the second portion extends in a direction substantially perpendicular to the shaft; a connecting plate coupling the second nut to the first portion, wherein the first nut is installed to the second portion with the first fastening element; wherein the first mounting surface and the second mounting surface are located within a space defined by the first portion, the second portion and the connecting plate, such that the ball screw spline is integrally installable to the housing.
A stackable concrete wall block, comprising a prism shaped body having front and rear faces (112, 114), in a stacked orientation, top and bottom faces (116, 118) for placement opposite like blocks located above or below in a stacked condition of the wall block and at least a pair of side walls for placement opposite a like block placed side by side to the wall block, and a lateral lip protruding from at least one of the side walls and coplanar with the front face for spacing the body of the wall block from the body of the like block placed side by side thereto, the front face of the block and the lip having an embossed three-dimensional surface structure, characterized in that the lateral lip comprises multiple staggered steps (120a, 120b), each step defined by two perpendicular walls respectively parallel to the side walls and the rear face of the block.
A metal shell of a glow plug for fastening to an engine head of a diesel engine, comprising: a plurality of metal shell sections disposed in an axial direction of the glow plug and having different material strengths; characterized in that the plurality of metal shell sections comprise a first metal section having a thread for fastening to the engine head, a second metal shell section connected to a lower side of the first metal shell section, and a third metal shell section connected to a lower side of the second metal shell section, and wherein the first metal shell section is formed of a steel wire rod for cold forging and the second and third metal shell sections (102, 103) are formed of a carbon steel wire rod for cold forging.
A method of visualizing a state of a power distribution system based on input data including input data values corresponding to input data locations distributed in a three-dimensional volume with structural elements, comprising the steps of defining triangles in the volume, wherein triangle vertices are located on or close to the structural elements, projecting each triangle onto a visualization plane, determining, for an output data location on the visualization plane within a projected triangle, a point of origin on the triangle, and interpolating, for the point of origin, input data values to generate an output data value corresponding to the output data location.
A composition comprising an effective amount of nintedanib for use in treating corneal graft rejection after a high-risk patient received corneal transplant, wherein nintedanib is administered in an amount effective to prevent graft rejection by inhibiting abnormal neovascularization and inflammation in the eye of said patient, and wherein the composition is in a form of a topical eye drop or implant. wherein nintedanib is administered in an amount effective to prevent graft rejection by inhibiting abnormal neovascularization and inflammation in the eye of said patient, and wherein the composition is in a form of a topical eye drop or implant.
A battery, comprising: a) an anode comprising an anode active material comprising sodium, lithium or an alloy or composite of at least one of sodium or lithium with at least one other metal for providing ions; b) a cathode comprising a cathode active material comprising elemental sulfur, elemental selenium or a mixture of elemental chalcogens; and c) an intermediate separator element positioned between the anode and cathode acting to separate liquid or gel electrolyte solutions in contact with the anode and cathode, through which metal ions and their counterions move between the anode and cathode during charge and discharge cycles of the battery; wherein the liquid or gel electrolyte solutions comprise a nonaqueous polar aprotic solvent or polymer and a conductive salt and at least one of the liquid or gel electrolyte solutions additionally comprise at least one organosulfur species; wherein the organosulfur species comprises at least one organic moiety and at least one -S-S n - linkage, n being an integer of 1 or more. a) an anode comprising an anode active material comprising sodium, lithium or an alloy or composite of at least one of sodium or lithium with at least one other metal for providing ions; b) a cathode comprising a cathode active material comprising elemental sulfur, elemental selenium or a mixture of elemental chalcogens; and c) an intermediate separator element positioned between the anode and cathode acting to separate liquid or gel electrolyte solutions in contact with the anode and cathode, through which metal ions and their counterions move between the anode and cathode during charge and discharge cycles of the battery;
A computer-implemented method for managing parallel processing on a computer system, wherein the computer system comprises one or more computers, wherein each of the computers has at least one CPU and at least one of the computers has multiple CPUs, the method comprising: determining a scheduling limit based on the number of CPUs of the computer system, wherein the scheduling limit restricts the number of worker threads available for executing tasks on the computer system, wherein a worker thread is available when the worker thread is runnable or temporarily stopped to let another thread run; executing a plurality of tasks on the computer system; determining an availability of a CPU of a computer of the computer system based on whether a load of the CPU exceeds a first threshold, wherein the CPU is determined to be unavailable and overloaded if the load of the CPU exceeds the first threshold; when the CPU is determined to be unavailable: reducing the scheduling limit in order to prevent further parallelization from being carried out on the computer system, scheduling a further task for execution on one of the CPUs according to the reduced scheduling limit, wherein the scheduling comprises limiting the worker threads available to execute tasks on the computer system, such that the quantity of worker threads available for executing tasks does not exceed the scheduling limit. determining a scheduling limit based on the number of CPUs of the computer system, wherein the scheduling limit restricts the number of worker threads available for executing tasks on the computer system, wherein a worker thread is available when the worker thread is runnable or temporarily stopped to let another thread run; executing a plurality of tasks on the computer system; determining an availability of a CPU of a computer of the computer system based on whether a load of the CPU exceeds a first threshold, wherein the CPU is determined to be unavailable and overloaded if the load of the CPU exceeds the first threshold; when the CPU is determined to be unavailable: reducing the scheduling limit in order to prevent further parallelization from being carried out on the computer system, scheduling a further task for execution on one of the CPUs according to the reduced scheduling limit, wherein the scheduling comprises limiting the worker threads available to execute tasks on the computer system, such that the quantity of worker threads available for executing tasks does not exceed the scheduling limit. reducing the scheduling limit in order to prevent further parallelization from being carried out on the computer system, scheduling a further task for execution on one of the CPUs according to the reduced scheduling limit, wherein the scheduling comprises limiting the worker threads available to execute tasks on the computer system, such that the quantity of worker threads available for executing tasks does not exceed the scheduling limit.
A method of using a mobile terminal for providing an operation state of an external device, comprising: displaying via the mobile terminal a preview image of a camera; identifying, by a controller of the mobile terminal, the external device displayed on the preview image, including a product name and an external shape thereof, by utilizing shape recognition and an electronic device database; the controller's obtaining, from the electronic device database, component information corresponding to the external shape of the identified external device, the component being inside the external device and not displayed in the preview image; requesting and receiving information about the operation state of the component from the external device through a communication unit of the mobile terminal; generating, by the controller, an indicator corresponding to the operation state of the component based on the information about the operation state and image information of the component; and displaying the indicator by matching the indicator to an area in the preview image to which the component of the external device related to the operation state belongs. displaying via the mobile terminal a preview image of a camera; identifying, by a controller of the mobile terminal, the external device displayed on the preview image, including a product name and an external shape thereof, by utilizing shape recognition and an electronic device database; the controller's obtaining, from the electronic device database, component information corresponding to the external shape of the identified external device, the component being inside the external device and not displayed in the preview image; requesting and receiving information about the operation state of the component from the external device through a communication unit of the mobile terminal; generating, by the controller, an indicator corresponding to the operation state of the component based on the information about the operation state and image information of the component; and displaying the indicator by matching the indicator to an area in the preview image to which the component of the external device related to the operation state belongs.
A microsurgical instrument comprising a handle and a removably insertable engine block, wherein the handle can be coupled with a work piece and comprises: - a base body, - an input shaft mounted in the base body, for motorized actuation of at least one degree of freedom of the work piece, - an engine interface, into which the engine block can be installed, and on which at least one electric contact and one mechanical coupling are situated, wherein the mechanical coupling comprises a claw coupling element that is connected non-rotatably with the input shaft and can be coupled with a corresponding claw coupling element of the engine block, - at least one actuation element, with which a current flow can be activated and deactivated by the electric contact of the engine interface, characterized in that the claw coupling element of the handle is mounted so that it can be slid lengthwise on the input shaft, wherein the claw coupling element of the handle comprises on its periphery at least two claw extensions extending in the longitudinal direction, which are peripherally distributed at equal or different angle distances, wherein the thickness of the claw extensions tapers toward their free ends pointing to the engine interface. - a base body, - an input shaft mounted in the base body, for motorized actuation of at least one degree of freedom of the work piece, - an engine interface, into which the engine block can be installed, and on which at least one electric contact and one mechanical coupling are situated, wherein the mechanical coupling comprises a claw coupling element that is connected non-rotatably with the input shaft and can be coupled with a corresponding claw coupling element of the engine block, - at least one actuation element, with which a current flow can be activated and deactivated by the electric contact of the engine interface,
A catheter-deliverable helical anchor for docking a prosthetic heart valve in a native mitral valve having native mitral valve leaflets and a native mitral valve annulus, the helical anchor comprising: a plurality of coils having a straightened configuration while being delivered to the native mitral valve and a preformed, coiled configuration after being delivered to the native mitral valve, the helical anchor adapted to support the prosthetic heart valve upon being fully delivered and implanted with an atrial coil portion above and a ventricular coil portion below the mitral valve annulus, and a plurality of anchoring arms coupled with the helical anchor and configured to engage the native mitral valve leaflets, wherein the ventricular coil portion includes a distal end portion, the distal end portion formed to extend radially outward relative to a next adjacent coil such that the distal end portion is spaced from the next adjacent coil. a plurality of coils having a straightened configuration while being delivered to the native mitral valve and a preformed, coiled configuration after being delivered to the native mitral valve, the helical anchor adapted to support the prosthetic heart valve upon being fully delivered and implanted with an atrial coil portion above and a ventricular coil portion below the mitral valve annulus, and a plurality of anchoring arms coupled with the helical anchor and configured to engage the native mitral valve leaflets, wherein the ventricular coil portion includes a distal end portion, the distal end portion formed to extend radially outward relative to a next adjacent coil such that the distal end portion is spaced from the next adjacent coil.
An enhanced services platform, said platform comprising: an interface for receiving a text communication from a user including a request for a desired data; an automated response module for parsing said communication and retrieving said data for inclusion in a response message that is sent to said user, wherein said enhanced services platform is further configured to generate a transaction record including a transaction ID field for storing a unique ID code for tracking said user's request, said transaction record including a user request field that has a copy of said text communication from said user requesting said desired data as well as a response message field including a copy of said response message that was sent to said user, wherein said response message includes a link including said transaction ID allowing said user to re-contact said enhanced services platform; and an operator assistance module configured to receive communications from said user initiated via said link and to use said transaction ID to retrieve said transaction record to provide further assistance regarding said user's request. an interface for receiving a text communication from a user including a request for a desired data; an automated response module for parsing said communication and retrieving said data for inclusion in a response message that is sent to said user, wherein said enhanced services platform is further configured to generate a transaction record including a transaction ID field for storing a unique ID code for tracking said user's request, said transaction record including a user request field that has a copy of said text communication from said user requesting said desired data as well as a response message field including a copy of said response message that was sent to said user, wherein said response message includes a link including said transaction ID allowing said user to re-contact said enhanced services platform; and an operator assistance module configured to receive communications from said user initiated via said link and to use said transaction ID to retrieve said transaction record to provide further assistance regarding said user's request.
Hand tool device having a tool spindle and an impact mechanism which has a striker and at least one cam guide, which drives the striker at least during impact drilling operation, wherein the tool spindle has at least one bearing face which movably supports the striker in at least one operating state, wherein the tool spindle has at least one impact face which the striker strikes in an axial impact direction at least during impact drilling operation, characterized in that the impact mechanism has an impact mechanism spindle with a bearing face which movably supports the striker in at least one operating state.
Pylon for mounting an engine to an aircraft structural element, said engine mounting pylon comprising a primary structure, a first fastening device for fastening to an aircraft engine and a second fastening device for fastening to said aircraft structural element, the second fastening device for fastening to said aircraft structural element comprises at least one brace (17, 21, 22, 27), a first brace-attachment device for mechanically connecting a first end of said at least one brace (17, 21, 22, 27) to the aircraft structural element, and a second brace-attachment device that mechanically connects a second end of said at least one brace (17, 21, 22, 27) to the primary structure of the pylon, the second fastening device for fastening to said aircraft structural element furthermore comprising a ball-joint attachment that mechanically connects the rear of the primary structure to the structural element of the aircraft, the mounting pylon comprising at least two lateral braces that take up the bending moments (MfZ) generated about a Z axis that is substantially perpendicular to the aircraft structural element to which the mounting pylon is attached and that passes through the ball-joint attachment, and at least two transverse braces that take up the torsion moments (MtX) generated about an X axis that is substantially parallel to the direction of movement of the aircraft and that passes through the ball-joint attachment.
A dry-granulation method for producing a tablet consisting of (a) metformin and at least one second active pharmaceutical ingredient in a combined amount of 50-90% w/w and (b) one or more excipients in an amount of 10-50% w/w including at least a binder which comprises (i) preparing granules from a powder comprising a binder and optionally one or more other excipients or active pharmaceutical ingredients by a process characterized in that a compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream in which the compacted mass flows, wherein the direction of the flow of the gas stream has a component which is contrary to that of the direction of flow of the compacted mass and collecting the accepted granules (ii) optionally blending the accepted granules with other components of the tablet in granular or fine powder form; and (iii) compressing the granules or blend to form a tablet.