mhurhangee/ep-ind-claims huggingface dataset:
A method of diagnosing, prognosing or monitoring or staging the progression of non-alcoholic fatty liver disease (NAFLD) in an individual, the method comprising detecting and quantifying the biomarker apolipoprotein F in a biological sample obtained from the individual, comparing the level of the biomarker to a control sample or reference sample/level and determining whether the level of the biomarker is indicative of progression of NAFLD, and thereby, diagnosing, prognosing or monitoring or staging the progression of NAFLD, wherein a decreasing level of apolipoprotein F, as compared with a control sample or reference sample/level, indicates increasing severity of NAFLD as it progresses through the stages, and wherein the biological sample is blood, serum or plasma.
A culture substrate for culturing cells, comprising: a culture sheet; and a culture sheet holding section that holds the culture sheet; wherein the culture sheet holding section has at least a hole part, and the culture sheet is formed on a bottom of the hole part, wherein the culture sheet has a plurality of culture regions configured to be cultured with cells to form three-dimensional tissues of the cells, and in the culture regions, a plurality of protrusions are formed, and wherein a plurality of hole structures are formed by a plurality of partitions that are higher than the protrusions, and lower than a sidewall of the hole part, and further comprising first regions and second regions in the culture regions, whereby width/diameter of the protrusions in the first regions are different from those in the second regions. a culture sheet; and a culture sheet holding section that holds the culture sheet; wherein the culture sheet holding section has at least a hole part, and the culture sheet is formed on a bottom of the hole part, wherein the culture sheet has a plurality of culture regions configured to be cultured with cells to form three-dimensional tissues of the cells, and in the culture regions, a plurality of protrusions are formed, and wherein a plurality of hole structures are formed by a plurality of partitions that are higher than the protrusions, and lower than a sidewall of the hole part, and further comprising first regions and second regions in the culture regions, whereby width/diameter of the protrusions in the first regions are different from those in the second regions.
Operating instrument for implanting a spinal implant, comprising an outer tube which has a hollow handle on its proximal end, wherein an inner rod can be moved in the outer tube and the hollow handle, and the inner rod is provided with a threaded region which extends beyond the distal end of the outer tube, wherein the threaded region serves for fastening to the rear region of an implant and for tensioning the implant with its rear region against the distal end region of the outer tube, wherein the distal end region of the outer tube is at least partially adapted to the rear region of the implant, characterised in that the inner rod is hollow and a further holding rod is provided which serves to fix the implant alone during X-ray examination, wherein the holding rod can be received in the hollow inner rod.
A vaporizer cartridge for use with a vaporizer device having a heating element, the cartridge comprising: a vaporizable material insert comprising an elongated body, the elongated body comprising a hollow core defined by sidewalls and a first end, wherein at least a portion of vaporizable material present within the vaporizable material insert surrounds at least the first end of the hollow core; and a seal configured to force heated air in the cartridge to pass through vaporizable material present within the vaporizable material insert and into the hollow core, wherein the heated air is generated in the cartridge. a vaporizable material insert comprising an elongated body, the elongated body comprising a hollow core defined by sidewalls and a first end, wherein at least a portion of vaporizable material present within the vaporizable material insert surrounds at least the first end of the hollow core; and a seal configured to force heated air in the cartridge to pass through vaporizable material present within the vaporizable material insert and into the hollow core, wherein the heated air is generated in the cartridge.
Multilayer (nE) including at least a first and a second magnetic stack, the multilayer having an out-of-plane magnetisation, each of said first and second magnetic stacks including: - A first element including a ferromagnetic layer; - A second element constituted of a metal layer able to confer on the assembly formed by the first and the second elements a magnetic anisotropy perpendicular to the plane of the layers, the first element further includes a refractory metal material, the second element being arranged on the first element, the first element of the second magnetic stack being arranged on the second element of the first magnetic stack. - A first element including a ferromagnetic layer; - A second element constituted of a metal layer able to confer on the assembly formed by the first and the second elements a magnetic anisotropy perpendicular to the plane of the layers,
A method of using a crushable pack comprising a plurality of interconnected side panels (11-14; 40-42) which define therein a volume 20) for receiving a product, the pack having an opening at one end, which opening is at least partially closed by a non-return end closure mechanism which operates to allow the product to be inserted fully past the end closure mechanism into said volume and to prevent subsequent removal of the product back past said end closure mechanism, the end (15; 43) of the pack opposite said one end being closed sufficiently to prevent removal of the product and the pack having a lengthwise axis extending between the two ends, wherein said end closure mechanism comprises one or more end flaps disposed within said volume and hingedly connected to respective side panels, said one or more end flaps being hingable in one direction further into said volume to allow said insertion of said product and being prevented from hinging in the other direction without distortion out of said volume thereby to prevent said removal of the product, the hinge axis of the or each end flap being substantially perpendicular to said lengthwise axis of the pack and wherein the pack is compressible to reduce said volume in use of the pack, the method comprising the step of fully inserting the product past the end closure mechanism into said volume, the end closure mechanism prevent subsequent removal of the product back past said end closure mechanism, and the method further comprising the step of compressing the pack to reduce the volume and to crush the product to produce a juice or crumb to be dispensed from the pack.
A method comprising: receiving a user request to paste an object from a clipboard to a target application; extracting from the clipboard a signed object data block associated with the object, the signed object data block comprising a payload data block and an object format identifier, the payload data block comprising a representation of the object, the object format identifier being indicative of a format of the representation and of the presence of a signature in the signed object data block, wherein the signature is a signature of the payload data block by a source application having copied the object to the clipboard; performing a verification of the signature; determining whether to paste or not the object to the target application based on the results of the verification; wherein the payload data block comprises a provenance data block including provenance information associated with the object. receiving a user request to paste an object from a clipboard to a target application; extracting from the clipboard a signed object data block associated with the object, the signed object data block comprising a payload data block and an object format identifier, the payload data block comprising a representation of the object, the object format identifier being indicative of a format of the representation and of the presence of a signature in the signed object data block, wherein the signature is a signature of the payload data block by a source application having copied the object to the clipboard; performing a verification of the signature; determining whether to paste or not the object to the target application based on the results of the verification; wherein the payload data block comprises a provenance data block including provenance information associated with the object.
A method for enhancing a measure of stability of a conjugated compound comprising a protein and a tobamovirus particle, wherein said measure of stability is selected from any one or more of integrity, potency, or concentration, the method comprising: exposing a tobamovirus particle to a pH of about 5.5 or less to activate the tobamovirus particle; and then mixing the tobamovirus particle and the protein in a conjugation reaction to form a conjugate mixture, wherein when placed in an unrefrigerated environment at a storage temperature for a time period, the integrity,potency, oreconcentration of the conjugate mixture is at least 90% of the initial integrity, initial potency, oreminitial concentration of the conjugate mixture, wherein the time period is at least 42 days after a release date of the conjugate mixture, wherein the release date occurs at constitution or dilution of a drug product, sometimes referred to as day 0.
A method of analyzing a biological sample of an organism, the method comprising: identifying a plurality of regions of a genome of the organism, each of the regions including one or more sites; analyzing a plurality of DNA molecules from the biological sample of the organism comprising nucleic acid molecules, wherein at least some of the nucleic acid molecules are cell-free in the biological sample, and wherein analyzing a DNA molecule includes: determining a location of the DNA molecule in the genome of the organism; and determining whether the DNA molecule is methylated at one or more sites; for each of the plurality of regions: determining a respective number of DNA molecules that are methylated at sites of the region; and calculating a respective region methylation level based on the respective number of DNA molecules that are methylated at sites of the region; comparing each of the respective region methylation levels to a corresponding reference methylation level of a reference group; determining an amount of regions that have a region methylation level exceeding the corresponding reference methylation level; comparing the amount of regions to a threshold value; and determining a classification of whether cancer is present based on the comparison. identifying a plurality of regions of a genome of the organism, each of the regions including one or more sites; analyzing a plurality of DNA molecules from the biological sample of the organism comprising nucleic acid molecules, wherein at least some of the nucleic acid molecules are cell-free in the biological sample, and wherein analyzing a DNA molecule includes: determining a location of the DNA molecule in the genome of the organism; and determining whether the DNA molecule is methylated at one or more sites; determining a location of the DNA molecule in the genome of the organism; and determining whether the DNA molecule is methylated at one or more sites; for each of the plurality of regions: determining a respective number of DNA molecules that are methylated at sites of the region; and calculating a respective region methylation level based on the respective number of DNA molecules that are methylated at sites of the region; determining a respective number of DNA molecules that are methylated at sites of the region; and calculating a respective region methylation level based on the respective number of DNA molecules that are methylated at sites of the region; comparing each of the respective region methylation levels to a corresponding reference methylation level of a reference group; determining an amount of regions that have a region methylation level exceeding the corresponding reference methylation level; comparing the amount of regions to a threshold value; and determining a classification of whether cancer is present based on the comparison.
A method for manufacturing a chip comprising a microchannel, the method comprising: fixing a cationic polymer having a quaternary onium group on at least one surface of each of a pair of resin substrates; and joining the resin substrates together at the surfaces on which the cationic polymer has been fixed whereby to form a microchannel which comprises an inner wall on which the cationic polymer is fixed; wherein the cationic polymer comprises a constituent unit derived from a monomer having a quaternary onium group. fixing a cationic polymer having a quaternary onium group on at least one surface of each of a pair of resin substrates; and joining the resin substrates together at the surfaces on which the cationic polymer has been fixed whereby to form a microchannel which comprises an inner wall on which the cationic polymer is fixed; wherein the cationic polymer comprises a constituent unit derived from a monomer having a quaternary onium group.
A valve stem cap device comprising: a cap member; an insert member comprising a threaded interior wall configured to thread onto a valve stem, the insert member further configured to be coupled to the cap member, characterized in that the cap member comprises one or more recesses disposed on an interior wall of the cap member, the insert member is configured to be inserted into the cap member and coupled to the cap member via a snap-fit engagement, the insert member further comprising one or more protrusions on an exterior of the insert member, the one or more protrusions configured to engage with the one or more recesses of the cap member, such that the insert member is prevented from rotating relative to the cap member. a cap member; an insert member comprising a threaded interior wall configured to thread onto a valve stem, the insert member further configured to be coupled to the cap member, characterized in that the cap member comprises one or more recesses disposed on an interior wall of the cap member, the insert member is configured to be inserted into the cap member and coupled to the cap member via a snap-fit engagement, the insert member further comprising one or more protrusions on an exterior of the insert member, the one or more protrusions configured to engage with the one or more recesses of the cap member, such that the insert member is prevented from rotating relative to the cap member.
A use of a thermoplastic structure comprising at least one layer comprised of a composition comprising a X/10.T/Y formula copolyamide, wherein: - X represents either the remnants of an aliphatic amino acid containing from 8 to 18 carbon atoms, or a lactam, or the unit X 1.X 2 representing the remnants from the condensation of an aliphatic diamine comprising from 6 to 18 carbon atoms and of a (cyclo)aliphatic diamine comprising from 6 to 18 carbon atoms; - 10.T represents the remnants of the condensation of a decanediamine and terephthalic acid; and - Y represents the remnants of the condensation of an aliphatic diamine comprising from 9 to 14 carbon atoms and an aromatic diacid, Y being different from the unit 10.T; the molar ratio of 10.T units in the copolyamide being greater than 0 %; the molar ratio of Y units in relation to all of the 10.T and Y units being from 0 to 30 %; and the percentage of X units being from 0.4 to 0.8 mole for a mole of 10.T and Y semi-aromatic units, for the transport of a heat transfer fluid in a vapor compression circuit, said fluid being selected from among hydrocarbon or hydrofluorocarbon compounds, ethers, hydrofluoroethers or fluoroolefins, including fluoropropenes, fluoropropanes and fluoroethanes, preferably from among 1,3,3,3-tetrafluoropropene, 2,3,3,3-tetrafluoropropene, 1,2,3,3,3-pentafluoropropene, 1,1,3,3-tetrafluoropropene, 3,3,3-trifluoropropene, 2,3,3-trifluoropropene, 1,1,1,2-tetrafluoroethane, 1,1,2,2-tetrafluoroethane, pentafluoroethane, difluoromethane, 1,1-difluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, 1,1,1-trifluoropropane, 1,1,1,3,3,3-hexafluoropropane, 1,1,1,3,3-pentafluoro-propane, 1,1,1,3,3-pentafluorobutane, trifluoroiodomethane and mixtures thereof; and in a more particularly preferred way said heat transfer fluid comprises or is 2,3,3,3-tetrafluoropropene, said fluid having added to it a lubricant, preferably selected from mineral oils, silicone oils, natural paraffins, naphthenes, synthetic paraffins, alkylbenzenes, polyalphaolefins, polyalkylene glycols, polyol esters and/or polyvinylethers; the lubricant being in a more particularly preferred way a polyalkylene glycol or a polyol ester. - X represents either the remnants of an aliphatic amino acid containing from 8 to 18 carbon atoms, or a lactam, or the unit X 1.X 2 representing the remnants from the condensation of an aliphatic diamine comprising from 6 to 18 carbon atoms and of a (cyclo)aliphatic diamine comprising from 6 to 18 carbon atoms; - 10.T represents the remnants of the condensation of a decanediamine and terephthalic acid; and - Y represents the remnants of the condensation of an aliphatic diamine comprising from 9 to 14 carbon atoms and an aromatic diacid, Y being different from the unit 10.T;
A therapeutic compression garment, comprising: (a) a body portion having a first side and a second side, with a plurality of bands extending from the first side; and (b) a spine portion having a first side and a second side, with a plurality of bands extending from the first side; wherein the bands extending from the first side of the body portion and the bands extending from the first side of the spine portion attach the body and spine portions (20, 30) together when the body and spine portions (20, 30) are wrapped around a body limb, wherein the second sides (27, 37) of the body and spine portions (20, 30) are attached together, and wherein both of the body and spine portions (20, 30) are narrower or wider across their mid-sections (29, 39) than at either or both of their top and bottom edges (21, 31; 23, 33) such that the garment assumes a non-planar shape when the body and spine portions (20, 30) are attached together, wherein the second sides (27, 37) of both of the body and spine portions (20, 30) are curved inwardly or outwardly at their mid-sections (29, 39) and outwardly or inwardly at their top and bottom edges (21, 31; 23, 33), wherein the second sides (27, 37) of the body and spine portions (20, 30) are secured together by a connector spanning the second side edges of the body and spine portions (20, 30), wherein the connector comprises a body having a series of spaced apart notches running along at least one side of the body to permit the connector to flex in a lateral direction perpendicular to the central axis of the connector. (a) a body portion having a first side and a second side, with a plurality of bands extending from the first side; and (b) a spine portion having a first side and a second side, with a plurality of bands extending from the first side; wherein the bands extending from the first side of the body portion and the bands extending from the first side of the spine portion attach the body and spine portions (20, 30) together when the body and spine portions (20, 30) are wrapped around a body limb, wherein the second sides (27, 37) of the body and spine portions (20, 30) are attached together, and wherein both of the body and spine portions (20, 30) are narrower or wider across their mid-sections (29, 39) than at either or both of their top and bottom edges (21, 31; 23, 33) such that the garment assumes a non-planar shape when the body and spine portions (20, 30) are attached together, wherein the second sides (27, 37) of both of the body and spine portions (20, 30) are curved inwardly or outwardly at their mid-sections (29, 39) and outwardly or inwardly at their top and bottom edges (21, 31; 23, 33), wherein the second sides (27, 37) of the body and spine portions (20, 30) are secured together by a connector spanning the second side edges of the body and spine portions (20, 30), wherein the connector comprises a body having a series of spaced apart notches running along at least one side of the body to permit the connector to flex in a lateral direction perpendicular to the central axis of the connector.
A photonic device comprising: a photonic device substrate; and a crosslinked polymer film on the photonic device substrate, the crosslinked polymer film comprising: 50 wt.% to 96 wt.% polymer chains comprising polymerized di(meth)acrylate monomers, or a combination of polymerized di(meth)acrylate monomers and mono(meth)acrylate monomers; 4 wt.% to 10wt.% polymerized multifunctional (meth)acrylate monomers crosslinking the polymer chains; 0.1 wt.% to 50 wt.% quantum dots; and light scattering nanoparticles. a photonic device substrate; and a crosslinked polymer film on the photonic device substrate, the crosslinked polymer film comprising: 50 wt.% to 96 wt.% polymer chains comprising polymerized di(meth)acrylate monomers, or a combination of polymerized di(meth)acrylate monomers and mono(meth)acrylate monomers; 4 wt.% to 10wt.% polymerized multifunctional (meth)acrylate monomers crosslinking the polymer chains; 0.1 wt.% to 50 wt.% quantum dots; and light scattering nanoparticles. 50 wt.% to 96 wt.% polymer chains comprising polymerized di(meth)acrylate monomers, or a combination of polymerized di(meth)acrylate monomers and mono(meth)acrylate monomers; 4 wt.% to 10wt.% polymerized multifunctional (meth)acrylate monomers crosslinking the polymer chains; 0.1 wt.% to 50 wt.% quantum dots; and light scattering nanoparticles.