A pipette tip (100, 200, 300, 400, 500, 600) comprising an exterior surface, an interior surface, a proximal region (130, 230, 330, 430, 530, 630), a distal region (135, 235, 335, 435, 535, 635) and a junction between the proximal region and the distal region, which proximal region comprises: an annular flange (110, 210, 310, 410, 510, 610) at a proximal terminus of the proximal region (105, 205, 305, 405, 505, 605), a distal terminal shoulder (115, 215, 315, 415, 515, 615) at the junction, a plurality of longitudinally-oriented grooves (140, 240, 340, 440, 540, 640) on the exterior surface of the pipette tip extending from the flange to the shoulder, wherein: each groove comprises a groove width (X 1, X 2, X 3, X 4, X 5, X 6) and a groove floor (150, 250, 350, 450, 550, 650), a plurality of longitudinally-oriented panels (170, 270, 370, 460, 560, 660) on the exterior surface of the pipette tip, wherein: each panel is adjacent to a groove, each panel or a portion thereof extends over a sealing zone, each panel comprises a panel sidewall (145, 245, 345, 445, 545, 645), a panel face (160, 260, 360, 455, 555, 655) and a panel width (Y 1, Y 2, Y 3, Y 4, Y 5, Y 6), and each panel width is greater than each groove width; a distance between a groove floor and an interior surface of a pipette tip opposite the groove floor (Z 1, Z 2, Z 3, Z 4, Z 5, Z 6), for each groove, is less than a distance between a panel face and an interior surface of a pipette tip opposite the panel face (W 1, W 2, W 3, W 4, W 5, W 6), for each panel; and which interior surface of a pipette tip defines a substantially frustum-shaped void and is substantially smooth and uniform. an annular flange (110, 210, 310, 410, 510, 610) at a proximal terminus of the proximal region (105, 205, 305, 405, 505, 605), a distal terminal shoulder (115, 215, 315, 415, 515, 615) at the junction, a plurality of longitudinally-oriented grooves (140, 240, 340, 440, 540, 640) on the exterior surface of the pipette tip extending from the flange to the shoulder, wherein: each groove comprises a groove width (X 1, X 2, X 3, X 4, X 5, X 6) and a groove floor (150, 250, 350, 450, 550, 650), a plurality of longitudinally-oriented panels (170, 270, 370, 460, 560, 660) on the exterior surface of the pipette tip, wherein: each panel is adjacent to a groove, each panel or a portion thereof extends over a sealing zone, each panel comprises a panel sidewall (145, 245, 345, 445, 545, 645), a panel face (160, 260, 360, 455, 555, 655) and a panel width (Y 1, Y 2, Y 3, Y 4, Y 5, Y 6), and each panel width is greater than each groove width; each panel is adjacent to a groove, each panel or a portion thereof extends over a sealing zone, each panel comprises a panel sidewall (145, 245, 345, 445, 545, 645), a panel face (160, 260, 360, 455, 555, 655) and a panel width (Y 1, Y 2, Y 3, Y 4, Y 5, Y 6), and each panel width is greater than each groove width; a distance between a groove floor and an interior surface of a pipette tip opposite the groove floor (Z 1, Z 2, Z 3, Z 4, Z 5, Z 6), for each groove, is less than a distance between a panel face and an interior surface of a pipette tip opposite the panel face (W 1, W 2, W 3, W 4, W 5, W 6), for each panel; and which interior surface of a pipette tip defines a substantially frustum-shaped void and is substantially smooth and uniform.