A tissue diagnosis method for detecting a target substance from a tissue sample by using a patch which includes a mesh structural body having a mesh structure configured to have micro-sized or nano-sized cavities and is configured to contain a substance in the cavities, the tissue diagnosis method comprising: placing the tissue sample in a reaction region; providing a fluorescence labeling substance for specifically labeling the target substance to the tissue sample by using a patch that contains the fluorescence labeling substance; and detecting the fluorescence-labeled target substance from the tissue sample, wherein the providing of the fluorescence labeling substance to the tissue sample includes: contacting the patch containing the fluorescence labeling substance with the tissue sample; and separating the patch containing the fluorescence labeling substances from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided, wherein the target substance is a target base sequence or a target protein included in the tissue sample, wherein the fluorescence labeling substance includes a fluorescence-labeled nucleic acid probe binding complementarily to the target base sequence or a fluorescence-labeled antibody binding specifically to the target protein, when the patch is in contact with the tissue sample, the fluorescence labeling substance moves to the reaction region, and wherein the patch is separated from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided. placing the tissue sample in a reaction region; providing a fluorescence labeling substance for specifically labeling the target substance to the tissue sample by using a patch that contains the fluorescence labeling substance; and detecting the fluorescence-labeled target substance from the tissue sample, wherein the providing of the fluorescence labeling substance to the tissue sample includes: contacting the patch containing the fluorescence labeling substance with the tissue sample; and separating the patch containing the fluorescence labeling substances from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided, wherein the target substance is a target base sequence or a target protein included in the tissue sample, wherein the fluorescence labeling substance includes a fluorescence-labeled nucleic acid probe binding complementarily to the target base sequence or a fluorescence-labeled antibody binding specifically to the target protein, when the patch is in contact with the tissue sample, the fluorescence labeling substance moves to the reaction region, and wherein the patch is separated from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided. contacting the patch containing the fluorescence labeling substance with the tissue sample; and separating the patch containing the fluorescence labeling substances from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided, wherein the target substance is a target base sequence or a target protein included in the tissue sample, wherein the fluorescence labeling substance includes a fluorescence-labeled nucleic acid probe binding complementarily to the target base sequence or a fluorescence-labeled antibody binding specifically to the target protein, when the patch is in contact with the tissue sample, the fluorescence labeling substance moves to the reaction region, and wherein the patch is separated from the tissue sample to remove from the reaction region a residual fluorescence labeling substance that is not bound to the target substance among the fluorescence labeling substance that has been provided.