A method for synthesizing an aryl-substituted lactone compound, comprising reacting a chloride and an arylboronic acid in presence of a dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, a palladium catalyst, a base, and under the protection of inert gases, at 80-120°C for 5-60 minutes to obtain an aryl-substituted lactone compound, wherein the dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate has a structure of wherein R 1 and R 2 is cyclopropyl, cyclopentyl, or cyclohexyl group, respectively; and R 3 is C1-C4 alkyl group, and wherein the arylboronic acid is R 5 C 6 H 4 B 2, the palladium catalyst is palladium acetate, the base is potassium carbonate, the organic solvent is toluene, the chloride has an inert carbon-chlorine bond that selectively undergoes coupling reaction with the arylboronic acid, and is an optically active chlorolactone having a structure of R 6 being an alkyl, phenyl, or heterocyclic group; R 7 being an alkyl group; the heterocyclic group is thiophene, furan, or pyridine; * being an optically active carbon, molar ratio of the palladium acetate, the dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, the potassium carbonate, the arylboronic acid, and the optically active chlorolactone is 0.05: (0.05~0.10): (3.0~4.5): (1.2~2.0): 1.0, and the aryl-substituted lactone compound substantially preserves the optical activity of the chlorolactone, wherein the optically active lactone compound has maintained its configuration and optical purity, and is represented by a formula wherein R 5 is an ortho-, meta-, or para-substituted alkyl, alkoxy, aryl, or hydrogen; R 6 is an alkyl, phenyl, or heterocyclic group; R 7 is an alkyl group; * is an optically active carbon; said heterocyclic group is thiophene, furan, or pyridine. wherein R 1 and R 2 is cyclopropyl, cyclopentyl, or cyclohexyl group, respectively; and R 3 is C1-C4 alkyl group, and wherein the arylboronic acid is R 5 C 6 H 4 B 2, the palladium catalyst is palladium acetate, the base is potassium carbonate, the organic solvent is toluene, the chloride has an inert carbon-chlorine bond that selectively undergoes coupling reaction with the arylboronic acid, and is an optically active chlorolactone having a structure of R 6 being an alkyl, phenyl, or heterocyclic group; R 7 being an alkyl group; the heterocyclic group is thiophene, furan, or pyridine; * being an optically active carbon, molar ratio of the palladium acetate, the dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, the potassium carbonate, the arylboronic acid, and the optically active chlorolactone is 0.05: (0.05~0.10): (3.0~4.5): (1.2~2.0): 1.0, and the aryl-substituted lactone compound substantially preserves the optical activity of the chlorolactone, wherein the optically active lactone compound has maintained its configuration and optical purity, and is represented by a formula wherein R 5 is an ortho-, meta-, or para-substituted alkyl, alkoxy, aryl, or hydrogen; R 6 is an alkyl, phenyl, or heterocyclic group; R 7 is an alkyl group; * is an optically active carbon; said heterocyclic group is thiophene, furan, or pyridine. R 6 being an alkyl, phenyl, or heterocyclic group; R 7 being an alkyl group; the heterocyclic group is thiophene, furan, or pyridine; * being an optically active carbon, molar ratio of the palladium acetate, the dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, the potassium carbonate, the arylboronic acid, and the optically active chlorolactone is 0.05: (0.05~0.10): (3.0~4.5): (1.2~2.0): 1.0, and the aryl-substituted lactone compound substantially preserves the optical activity of the chlorolactone, wherein the optically active lactone compound has maintained its configuration and optical purity, and is represented by a formula wherein R 5 is an ortho-, meta-, or para-substituted alkyl, alkoxy, aryl, or hydrogen; R 6 is an alkyl, phenyl, or heterocyclic group; R 7 is an alkyl group; * is an optically active carbon; said heterocyclic group is thiophene, furan, or pyridine.