A system for cleaning body-inserted tubes, e.g., endotracheal tubes, and/or airways comprising: a suction catheter (1505, 3200, 3300, 3400, 3500) adapted to clean an interior surface of a body-inserted tube, the suction catheter comprising: a cleaning portion (3210, 3410, 3510) located at or near a distal end (1502, 1502A) of the suction catheter, the cleaning portion comprising at least one expandable cleaning member (2726, 3240, 3230, 3340, 3440, 3540, 4515, 4615); a proximal controller (3800, 3900, 4000, 4650) located at a proximal end of the suction catheter, wherein the proximal controller is adapted to facilitate the following operational states: i) deployment of the at least one expandable cleaning member independently, ii) activation of suction through the suction catheter independently, or iii) simultaneous deployment of the at least one cleaning member and activation of suction through the suction catheter; wherein, upon expansion of the at least one expandable cleaning member, at least a portion of the at least one expandable cleaning member is adapted to contact the interior surface of the body-inserted tube such that when the suction catheter is withdrawn from the body-inserted tube, biofilm or debris collected on the interior surface is removed by the at least one cleaning member; and at least one suction port disposed proximal of the at least one cleaning portion along a length of the suction catheter, the at least one suction port being in fluid communication with a lumen extending from the proximal controller to the at least one suction port, wherein the at least one suction port is configured to suction at least a portion of the removed biofilm from the body-inserted tube along a proximal side of the cleaning portion. a cleaning portion (3210, 3410, 3510) located at or near a distal end (1502, 1502A) of the suction catheter, the cleaning portion comprising at least one expandable cleaning member (2726, 3240, 3230, 3340, 3440, 3540, 4515, 4615); a proximal controller (3800, 3900, 4000, 4650) located at a proximal end of the suction catheter, wherein the proximal controller is adapted to facilitate the following operational states: i) deployment of the at least one expandable cleaning member independently, ii) activation of suction through the suction catheter independently, or iii) simultaneous deployment of the at least one cleaning member and activation of suction through the suction catheter; i) deployment of the at least one expandable cleaning member independently, ii) activation of suction through the suction catheter independently, or iii) simultaneous deployment of the at least one cleaning member and activation of suction through the suction catheter; wherein, upon expansion of the at least one expandable cleaning member, at least a portion of the at least one expandable cleaning member is adapted to contact the interior surface of the body-inserted tube such that when the suction catheter is withdrawn from the body-inserted tube, biofilm or debris collected on the interior surface is removed by the at least one cleaning member; and at least one suction port disposed proximal of the at least one cleaning portion along a length of the suction catheter, the at least one suction port being in fluid communication with a lumen extending from the proximal controller to the at least one suction port, wherein the at least one suction port is configured to suction at least a portion of the removed biofilm from the body-inserted tube along a proximal side of the cleaning portion.