A device for applying a medical liquid adhesive in open surgery operations from a vial or ampoule with deformable and flexible walls, the device comprising a body provided with a housing cavity of said vial or ampoule, a cannula for guiding the discharge of adhesive from said vial or ampoule and means (4,5,6,17,18) for actuating the walls of said vial or ampoule, said actuator means (4,5,6,17,18) being capable of exerting a compression force on the walls of said vial or ampoule to dispense said adhesive, wherein - said actuator means comprise a tightening pincer that is mounted on a support inside said body, the arms of said pincer configuring a pair of actuator elements opposite each other with relative movement in respect of said body, said support acting as a pivot for said arms and the body of said device being provided with a pair of apertures through which the arms of said pincer emerge to be actuated, a portion of each one of said arms being disposed in correspondence with the housing cavity of said vial or ampoule and each one of said arms including a compression tooth of said vial or ampoule, said compression teeth determining two opposite pressure points through which deformation of flexible walls of said vial or ampoule is achieved to pump said adhesive from said vial or ampoule through the cannula, wherein - the body of said device comprises an aperture which is configured to allow the insertion of said vial or ampoule in the aforesaid housing cavity, said cannula including a joining portion associated to said body, said joining portion of the cannula being provided with means for coupling a discharge mouth of said vial or ampoule, it being possible to decouple said vial or ampoule from said cannula and to extract it through the aforesaid aperture in order to carry out a replacement once the liquid of said vial or ampoule has been dispensed. - said actuator means comprise a tightening pincer that is mounted on a support inside said body, the arms of said pincer configuring a pair of actuator elements opposite each other with relative movement in respect of said body, said support acting as a pivot for said arms and the body of said device being provided with a pair of apertures through which the arms of said pincer emerge to be actuated, a portion of each one of said arms being disposed in correspondence with the housing cavity of said vial or ampoule and each one of said arms including a compression tooth of said vial or ampoule, said compression teeth determining two opposite pressure points through which deformation of flexible walls of said vial or ampoule is achieved to pump said adhesive from said vial or ampoule through the cannula, wherein - the body of said device comprises an aperture which is configured to allow the insertion of said vial or ampoule in the aforesaid housing cavity, said cannula including a joining portion associated to said body, said joining portion of the cannula being provided with means for coupling a discharge mouth of said vial or ampoule, it being possible to decouple said vial or ampoule from said cannula and to extract it through the aforesaid aperture in order to carry out a replacement once the liquid of said vial or ampoule has been dispensed.