A method of production of a combined composite for stabilization of active or activable biological materials comprising the steps of: a) providing a simple composite in the form of a sol-gel immobilizing uniquely by encapsulation active or activable biological materials of one or more different natures, finely divided and with low water content; b) providing a second sol-gel immobilizing the simple composite of a), comprising: i) preparing a suspension of simple composite of a) in a phosphate-buffer solution 100 mM pH = 6,8 ± 0,2 at a mass/volume concentration between 0,83% and 3,34% in reference to the volume of the final reacting mixture; ii) effecting the hydrolysis of tetramethyl orthosilicate by acidic catalysis adding to tetramethyl orthosilicate an HCl solution at a concentration of 4,50mM to 8,34 mM in the proportion of 28% of the final volume of this mixture; iii) adding the mixture from ii) to an equal volume of the suspension from i) at 25°C to 30°C allowing polymerization to occur until the obtained combined composite has a consistency that enables it to be fragmented; iv) fragmenting the combined composite obtained from iii) to granules of two classes of size: equal and smaller than approximately 2 mm 3 and approximately between 2 mm 3 and 4 mm 3; v) optionally, incubating the fragmented combined composite of iv) during 24 hours in bovine serum albumin 2,0% m/v solubilized in saline phosphate buffer 10 mM pH=7,3 in a proportion of three volumes of the incubating solution to one volume of combined composite; vi) maturating the fragmented combined composite by drying on a surface until a mass-decrease of about 70% and available water content (a w) of about 20 ppm; whereby a combined composite is obtained doubly immobilizing in sol-gel uniquely by encapsulation said active or activable biological materials, wherein the loss by leaching of said biological materials is reduced, being preserved its activity or activation capability. a) providing a simple composite in the form of a sol-gel immobilizing uniquely by encapsulation active or activable biological materials of one or more different natures, finely divided and with low water content; b) providing a second sol-gel immobilizing the simple composite of a), comprising: i) preparing a suspension of simple composite of a) in a phosphate-buffer solution 100 mM pH = 6,8 ± 0,2 at a mass/volume concentration between 0,83% and 3,34% in reference to the volume of the final reacting mixture; ii) effecting the hydrolysis of tetramethyl orthosilicate by acidic catalysis adding to tetramethyl orthosilicate an HCl solution at a concentration of 4,50mM to 8,34 mM in the proportion of 28% of the final volume of this mixture; iii) adding the mixture from ii) to an equal volume of the suspension from i) at 25°C to 30°C allowing polymerization to occur until the obtained combined composite has a consistency that enables it to be fragmented; iv) fragmenting the combined composite obtained from iii) to granules of two classes of size: equal and smaller than approximately 2 mm 3 and approximately between 2 mm 3 and 4 mm 3; v) optionally, incubating the fragmented combined composite of iv) during 24 hours in bovine serum albumin 2,0% m/v solubilized in saline phosphate buffer 10 mM pH=7,3 in a proportion of three volumes of the incubating solution to one volume of combined composite; vi) maturating the fragmented combined composite by drying on a surface until a mass-decrease of about 70% and available water content (a w) of about 20 ppm; i) preparing a suspension of simple composite of a) in a phosphate-buffer solution 100 mM pH = 6,8 ± 0,2 at a mass/volume concentration between 0,83% and 3,34% in reference to the volume of the final reacting mixture; ii) effecting the hydrolysis of tetramethyl orthosilicate by acidic catalysis adding to tetramethyl orthosilicate an HCl solution at a concentration of 4,50mM to 8,34 mM in the proportion of 28% of the final volume of this mixture; iii) adding the mixture from ii) to an equal volume of the suspension from i) at 25°C to 30°C allowing polymerization to occur until the obtained combined composite has a consistency that enables it to be fragmented; iv) fragmenting the combined composite obtained from iii) to granules of two classes of size: equal and smaller than approximately 2 mm 3 and approximately between 2 mm 3 and 4 mm 3; v) optionally, incubating the fragmented combined composite of iv) during 24 hours in bovine serum albumin 2,0% m/v solubilized in saline phosphate buffer 10 mM pH=7,3 in a proportion of three volumes of the incubating solution to one volume of combined composite; vi) maturating the fragmented combined composite by drying on a surface until a mass-decrease of about 70% and available water content (a w) of about 20 ppm;