A process for preparing a compound of Formula IIa from a compound of Formula I in a reaction mixture according to the following reaction scheme: the process comprising: (i) forming a reaction mixture comprising the compound of Formula I, organic halide, solvent system, phase transfer catalyst, and base, (ii) reacting the reaction mixture to form a reaction product mixture comprising the compound of Formula IIa, and (iii) isolating the compound of Formula IIa from the reaction product mixture, wherein the solvent system consists essentially of water; X is a halide; each R 5, R 10 and R 15 is independently selected from H, C 1 -C 10 hydrocarbyl or from C 1 -C 5 hydrocarbyl, wherein each hydrocarbyl is optionally substituted, two geminal R 5, R 10 and/or R 15 groups are oxo, or two geminal R 5, R 10 and/or R 15 groups form a 3, 4, 5, 6, or 7-membered carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl is optionally substituted; mor is selected from: wherein mor is optionally substituted with one or more R 7 groups independently selected from F, Cl, Br, I, -CH 3, -CH 2 CH 3, -CH 2 CH 2 CH 3, -CH(CH 3) 2,-C(CH 3) 3, -CH 2 OCH 3, -CHF 2, -CN, -CF 3, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH,-CH 2 C(CH 3) 2 OH, -CH(CH 3)OH, -CH(CH 2 CH 3)OH, -CH 2 CH CH 3, -C(CH 3) 2 OH, -C(CH 3) 2 OCH 3, -CH(CH 3)F, -C(CH 3)F 2, -CH(CH 2 CH 3)F, -C(CH 2 CH 3) 2 F, -CO 2 H,-CONH 2, -CON(CH 2 CH 3) 2, -COCH 3, -CON(CH 3) 2, -NO 2, -NH 2, -NHCH 3, -N(CH 3) 2, -NHCH 2 CH 3, -NHCH(CH 3) 2, -NHCH 2 CH 2 OH, -NHCH 2 CH 2 OCH 3, -NHCOCH 3,-NHCOCH 2 CH 3, -NHCOCH 2 OH, -NHS 2 CH 3, -N(CH 3)S 2 CH 3, =O, -OH,-OCH 3, -OCH 2 CH 3, -OCH(CH 3) 2, -SH, -NHC NHCH 3, -NHC NHCH 2 CH 3,-S CH 3, -S CH 2 CH 3, -S 2 CH 3, -S 2 NH 2, -S 2 NHCH 3, -S 2 N(CH 3) 2, and -CH 2 S 2 CH 3; and wherein in Formula I R 20 is -OH or -NHR 21 wherein R 21 is as defined for R 5, and wherein in Formula IIa R 20 is -O- or -NR 21 -. (i) forming a reaction mixture comprising the compound of Formula I, organic halide, solvent system, phase transfer catalyst, and base, (ii) reacting the reaction mixture to form a reaction product mixture comprising the compound of Formula IIa, and (iii) isolating the compound of Formula IIa from the reaction product mixture, the solvent system consists essentially of water; X is a halide; each R 5, R 10 and R 15 is independently selected from H, C 1 -C 10 hydrocarbyl or from C 1 -C 5 hydrocarbyl, wherein each hydrocarbyl is optionally substituted, two geminal R 5, R 10 and/or R 15 groups are oxo, or two geminal R 5, R 10 and/or R 15 groups form a 3, 4, 5, 6, or 7-membered carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl is optionally substituted; mor is selected from: wherein mor is optionally substituted with one or more R 7 groups independently selected from F, Cl, Br, I, -CH 3, -CH 2 CH 3, -CH 2 CH 2 CH 3, -CH(CH 3) 2,-C(CH 3) 3, -CH 2 OCH 3, -CHF 2, -CN, -CF 3, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH,-CH 2 C(CH 3) 2 OH, -CH(CH 3)OH, -CH(CH 2 CH 3)OH, -CH 2 CH CH 3, -C(CH 3) 2 OH, -C(CH 3) 2 OCH 3, -CH(CH 3)F, -C(CH 3)F 2, -CH(CH 2 CH 3)F, -C(CH 2 CH 3) 2 F, -CO 2 H,-CONH 2, -CON(CH 2 CH 3) 2, -COCH 3, -CON(CH 3) 2, -NO 2, -NH 2, -NHCH 3, -N(CH 3) 2, -NHCH 2 CH 3, -NHCH(CH 3) 2, -NHCH 2 CH 2 OH, -NHCH 2 CH 2 OCH 3, -NHCOCH 3,-NHCOCH 2 CH 3, -NHCOCH 2 OH, -NHS 2 CH 3, -N(CH 3)S 2 CH 3, =O, -OH,-OCH 3, -OCH 2 CH 3, -OCH(CH 3) 2, -SH, -NHC NHCH 3, -NHC NHCH 2 CH 3,-S CH 3, -S CH 2 CH 3, -S 2 CH 3, -S 2 NH 2, -S 2 NHCH 3, -S 2 N(CH 3) 2, and -CH 2 S 2 CH 3; and wherein in Formula I R 20 is -OH or -NHR 21 wherein R 21 is as defined for R 5, and wherein in Formula IIa R 20 is -O- or -NR 21 -.