mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula Q: wherein (i) R 1 is H or C 1-6 alkyl; (ii) R 2 is C 1-6 alkyl, C 3-8 cycloalkyl optionally substituted with one or more amino, C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl, C 0-6 alkylaminoC 0-6 alkyl, -G-J wherein: G is C 1-6 alkylene; J is C 3-6 cycloalkyl or heteroC 3-6 cycloalkyl optionally substituted with C 1-6 alkyl; (iii) R 3 is D-E-F wherein 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene; 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene or amino; and 3. F is heteroC 3-8 cycloalkyl optionally substituted with C 1-6 alkyl; (iv) R 4 is aryl optionally substituted with one or more halo, hydroxy or C 1-6 alkoxy; heteroaryl or heteroC 3-6 cycloalkyl; and (v) R 5 is H, C 1-6 alkyl, C 3-8 cycloalkyl, heteroaryl, aryl or biphenyl-4-ylmethyl; wherein "aryl" or "arylene" is a mono or bicyclic aromatic hydrocarbon optionally substituted with C 1-6 alkyl, halogen, haloC 1-6 alkyl, hydroxy, carboxy, or an additional aryl or heteroaryl; and "heteroaryl" is an aromatic moiety wherein one or more of the atoms making up the aromatic ring is sulfur or nitrogen rather than carbon, which heteroaryl or heteroarylene may be optionally substituted with C 1-6 alkyl, halogen, haloC 1-6 alkyl, hydroxy or carboxy; in free or salt form. (i) R 1 is H or C 1-6 alkyl; (ii) R 2 is C 1-6 alkyl, C 3-8 cycloalkyl optionally substituted with one or more amino, C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl, C 0-6 alkylaminoC 0-6 alkyl, -G-J wherein: G is C 1-6 alkylene; J is C 3-6 cycloalkyl or heteroC 3-6 cycloalkyl optionally substituted with C 1-6 alkyl; C 1-6 alkyl, C 3-8 cycloalkyl optionally substituted with one or more amino, C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl, C 0-6 alkylaminoC 0-6 alkyl, -G-J wherein: G is C 1-6 alkylene; J is C 3-6 cycloalkyl or heteroC 3-6 cycloalkyl optionally substituted with C 1-6 alkyl; G is C 1-6 alkylene; J is C 3-6 cycloalkyl or heteroC 3-6 cycloalkyl optionally substituted with C 1-6 alkyl; (iii) R 3 is D-E-F wherein 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene; 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene or amino; and 3. F is heteroC 3-8 cycloalkyl optionally substituted with C 1-6 alkyl; D-E-F wherein 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene; 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene or amino; and 3. F is heteroC 3-8 cycloalkyl optionally substituted with C 1-6 alkyl; 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene; 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene or amino; and 3. F is heteroC 3-8 cycloalkyl optionally substituted with C 1-6 alkyl; (iv) R 4 is aryl optionally substituted with one or more halo, hydroxy or C 1-6 alkoxy; heteroaryl or heteroC 3-6 cycloalkyl; and (v) R 5 is H, C 1-6 alkyl, C 3-8 cycloalkyl, heteroaryl, aryl or biphenyl-4-ylmethyl;
An aerosol delivery device comprising: an aerosol generator portion configured to receive a first aerosol precursor, wherein the aerosol generator portion is a passive aerosol generator portion; an air flow passage configured to direct air past the aerosol generator portion to pick up the first aerosol precursor from the aerosol generator portion to form a first aerosol; and a support for maintaining the aerosol generator portion in a substantially central position in the air flow passage; characterised in that the device further comprises a storage for storing the first aerosol precursor wherein the storage comprises a tank configured to store the first aerosol precursor as a free liquid. an aerosol generator portion configured to receive a first aerosol precursor, wherein the aerosol generator portion is a passive aerosol generator portion; an air flow passage configured to direct air past the aerosol generator portion to pick up the first aerosol precursor from the aerosol generator portion to form a first aerosol; and a support for maintaining the aerosol generator portion in a substantially central position in the air flow passage; characterised in that the device further comprises a storage for storing the first aerosol precursor wherein the storage comprises a tank configured to store the first aerosol precursor as a free liquid.
Method for producing a modified rubber mixture by using a fraction of comminuted vulcanized rubber material, in which a starting material is mixed with supercritical CO 2 in a pressure- and gas-tight unit under a pressure of at least 63 bar and at a temperature of at least 31°C and is subsequently extruded while the pressure is maintained or increased and mechanical energy is introduced, characterized in that an input rubber mixture comprising a masterbatch with the constituents of a rubber mixture and the vulcanized rubber fraction is used as the starting material in order to obtain the modified rubber mixture.
A wind turbine blade comprising: a first blade portion having a shell that defines a suction side, a pressure side, a leading edge, and a trailing edge of the blade, the first blade portion further including a first spar cap portion; a second blade portion having a shell that defines a suction side, a pressure side, a leading edge, and a trailing edge of the blade, the second blade portion further including a second spar cap portion; and a connection joint for coupling the first and second blade portions (22, 24) together; characterised in that the connection joint includes: a plurality of first metal layers associated with the first spar cap portion; and a plurality of second metal layers associated with the second spar cap portion, wherein the plurality of first metal layers and the plurality of second metal layers (62, 64) are interleaved and clamped together between the first and second blade portions (22, 24). a first blade portion having a shell that defines a suction side, a pressure side, a leading edge, and a trailing edge of the blade, the first blade portion further including a first spar cap portion; a second blade portion having a shell that defines a suction side, a pressure side, a leading edge, and a trailing edge of the blade, the second blade portion further including a second spar cap portion; and a connection joint for coupling the first and second blade portions (22, 24) together; characterised in that the connection joint includes: a plurality of first metal layers associated with the first spar cap portion; and a plurality of second metal layers associated with the second spar cap portion, wherein the plurality of first metal layers and the plurality of second metal layers (62, 64) are interleaved and clamped together between the first and second blade portions (22, 24). a plurality of first metal layers associated with the first spar cap portion; and a plurality of second metal layers associated with the second spar cap portion, wherein the plurality of first metal layers and the plurality of second metal layers (62, 64) are interleaved and clamped together between the first and second blade portions (22, 24).
A method of manufacturing a composite aerospace structural member comprising a unitary beam that includes a central web, a pair of flanges integral with the central web and forming an I-shaped cross-section, a laminated composite cap that covers and is co-welded to each of the pair of flanges, and a pair of fittings on opposite ends of the unitary beam that are formed integral with the web and the pair of flanges, wherein the method comprises: molding a thermoplastic resin first component reinforced with discontinuous fibers by compression molding a flowable mixture of a thermoplastic resin and discontinuous, randomly oriented fibers, wherein the thermoplastic resin first component comprises the unitary beam; laying up a thermoplastic resin second component reinforced with substantially continuous fibers, wherein the thermoplastic resin second component comprises the laminated composite caps; and co-welding the thermoplastic resin first and second components. molding a thermoplastic resin first component reinforced with discontinuous fibers by compression molding a flowable mixture of a thermoplastic resin and discontinuous, randomly oriented fibers, wherein the thermoplastic resin first component comprises the unitary beam; laying up a thermoplastic resin second component reinforced with substantially continuous fibers, wherein the thermoplastic resin second component comprises the laminated composite caps; and co-welding the thermoplastic resin first and second components.
Electric motor having an external rotor and an internal rotor, whereby the stator which bears the excitation coils is designed in a hollow cylindrical manner and engages with the external rotor which is designed to be pot-shaped and is connected in a fixed manner to the housing or a part of the electric motor that is connected to the electric motor on the front face, whereby the stator has several stator teeth which are held by supports (5, 6, 7, 13, 27) which extend in an axial and radial direction between the stator teeth, characterised in that the supports (5, 6, 7, 13, 27) are initially arranged on the housing or on a part of the electric motor that is connected in a fixed manner to the housing and are connected in a non-positive and/or positive-locking manner to the housing or the part of the electric motor that is connected in a fixed manner to the housing and afterwards the stator teeth are slidden on the supports (5, 6, 7, 13, 27) and therefore held or supported by the supports.
A power management system for a work machine, the power management system comprising: a real time data interface configured to receive real time work machine data; a processor configured to compute current machine power requirements based on the real time work machine data; and the processor further configured to compute an optimized engine speed based on the current machine power requirements and a desired reserve power, and to inform an operator of the optimized engine speed, and the processor is further configured to predict upcoming machine power requirements based on the real time work machine data; and the processor is further configured to compute the optimized engine speed based on the current machine power requirements, the upcoming machine power requirements and the desired reserve power, and the power management system further comprising a predictive data interface configured to receive predictive data; wherein the processor is further configured to predict the upcoming machine power requirements based on the predictive data and the real time work machine data, characterized in that, the predictive data includes topographical data for a field to be harvested by the work machine. a real time data interface configured to receive real time work machine data; a processor configured to compute current machine power requirements based on the real time work machine data; and the processor further configured to compute an optimized engine speed based on the current machine power requirements and a desired reserve power, and to inform an operator of the optimized engine speed, and the processor is further configured to predict upcoming machine power requirements based on the real time work machine data; and the processor is further configured to compute the optimized engine speed based on the current machine power requirements, the upcoming machine power requirements and the desired reserve power, and the power management system further comprising a predictive data interface configured to receive predictive data; wherein the processor is further configured to predict the upcoming machine power requirements based on the predictive data and the real time work machine data, characterized in that, the predictive data includes topographical data for a field to be harvested by the work machine.
A solution with an effective amount of treprostinil sodium for use in a method of reducing the occurrence of a blood stream infection in a human suffering from pulmonary arterial hypertension and being treated with tresprostinil, said solution being obtainable by a process comprising diluting a starting solution of treprostinil sodium with a buffer comprising glycine and having a pH of greater than 10.
A power tool system, comprising: a power tool; and a battery pack comprising: a housing; at least one battery cell housed in the housing; a connection section including a first electrical connector configured to supply power to the power tool when the battery pack is connected to the power tool, the connection section being located at a top of the battery pack; and a charging port configured to supply power to an external device; characterized in that: a wireless transmitter is housed in the battery pack housing and is configured to wirelessly communicate with an electronic device; and the charging port can be in an on state in which the charging port is operable to supply power to the external device and an off state in which the charging port is not operable to supply power to the external device; and the charging port is located at the top of the battery pack such that the charging port is protected from debris when the battery pack is connected to the power tool. a power tool; and a battery pack comprising: a housing; at least one battery cell housed in the housing; a connection section including a first electrical connector configured to supply power to the power tool when the battery pack is connected to the power tool, the connection section being located at a top of the battery pack; and a charging port configured to supply power to an external device; characterized in that: a wireless transmitter is housed in the battery pack housing and is configured to wirelessly communicate with an electronic device; and the charging port can be in an on state in which the charging port is operable to supply power to the external device and an off state in which the charging port is not operable to supply power to the external device; and the charging port is located at the top of the battery pack such that the charging port is protected from debris when the battery pack is connected to the power tool. a wireless transmitter is housed in the battery pack housing and is configured to wirelessly communicate with an electronic device; and the charging port can be in an on state in which the charging port is operable to supply power to the external device and an off state in which the charging port is not operable to supply power to the external device; and the charging port is located at the top of the battery pack such that the charging port is protected from debris when the battery pack is connected to the power tool.
A polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one E3 ligase recognition motif in the light chain, wherein said E3 ligase recognition motif is a binding motif for the E3 ligase MDM2, wherein the light chain of the neurotoxin polypeptide is obtained by the modification from a light chain being encoded by a polynucleotide comprising a nucleic acid sequence selected from the group consisting of: a) a nucleic acid sequence having a nucleotide sequence as shown in SEQ ID NO: 1,3,5,7,9,81, 11, 13 or 15; b) a nucleic acid sequence encoding a polypeptide having an amino acid sequence as shown in SEQ ID NO: 2, 4, 6, 8, 10, 82, 12, 14, or 16; and c) a nucleic acid sequence being at least 40% identical to the nucleic acid sequence of a) or b). a) a nucleic acid sequence having a nucleotide sequence as shown in SEQ ID NO: 1,3,5,7,9,81, 11, 13 or 15; b) a nucleic acid sequence encoding a polypeptide having an amino acid sequence as shown in SEQ ID NO: 2, 4, 6, 8, 10, 82, 12, 14, or 16; and c) a nucleic acid sequence being at least 40% identical to the nucleic acid sequence of a) or b).
A driving control system for a vehicle, comprising - a sensor unit, - a data storage unit, - a user communication means, and - a control unit, the sensor unit being arrangeable in a first vehicle and configured to generate at least one user-specific driving parameter of at least one user travelling with the first vehicle, the at least one user-specific driving parameter being based on a driver's driving behavior of the first vehicle, the user communication means being configured to receive an input of the user to store the at least one user-specific driving parameter in the data storage unit and activate the stored at least one user-specific driving parameter in a second vehicle to be occupied by the user, the control unit being configured to transmit the at least one user-specific driving parameter of the user from the data storage unit to the second vehicle, the control unit being configured to control the second vehicle based on the transmitted at least one user-specific driving parameter, the control unit further being configured to generate a user profile of the user based on the at least one user-specific driving parameter, the control unit being configured to transmit the at least one user-specific driving parameter only if the user activates the at least one user-specific driving parameter in the second vehicle, and the user communication means being executable by a mobile application integrated in a mobile device of the user. - a sensor unit, - a data storage unit, - a user communication means, and - a control unit, the sensor unit being arrangeable in a first vehicle and configured to generate at least one user-specific driving parameter of at least one user travelling with the first vehicle, the at least one user-specific driving parameter being based on a driver's driving behavior of the first vehicle, the user communication means being configured to receive an input of the user to store the at least one user-specific driving parameter in the data storage unit and activate the stored at least one user-specific driving parameter in a second vehicle to be occupied by the user, the control unit being configured to transmit the at least one user-specific driving parameter of the user from the data storage unit to the second vehicle, the control unit being configured to control the second vehicle based on the transmitted at least one user-specific driving parameter, the control unit further being configured to generate a user profile of the user based on the at least one user-specific driving parameter, the control unit being configured to transmit the at least one user-specific driving parameter only if the user activates the at least one user-specific driving parameter in the second vehicle, and the user communication means being executable by a mobile application integrated in a mobile device of the user.
Pharmaceutical or nutraceutical composition or food supplement comprising a mixture of resveratrol supported on magnesium hydroxide and of non-supported pure resveratrol synthetized or natural for use in the treatment of female infertility in the human species.
An inserting device for inserting the contents of an envelope into an envelope, wherein the inserting device (1, 1') comprises a holder for empty envelopes, a flap opener for opening an envelope flap of the envelope, transport members for transporting the envelopes from the holder to a packing pocket, on which the envelopes are filled, a feed device for feeding the envelope contents to the packing pocket and into the packing pocket, and removal members for the further transport of the filled envelope, wherein the transport members comprise a funnel, which is movable at a first angle relative to a flap guide of the packing pocket and mounted on the inserting device (1, 1') or on a mounting rail, for aligning the envelope with the packing pocket, as well as at least one pulling means, cooperating temporarily with the flap guide of the packing pocket at a second angle to the flap guide, for at least partially drawing the envelope onto the packing pocket, and means for synchronising the movement of the funnel and the pulling means, whereby the funnel and the pulling means are movable from a first position when the envelope flap is received by the funnel, to a second position after the envelope flap has been placed on the flap guide, and a transport angle (Wt), between the fed envelope and the flap guide can be varied during the drawing of the envelope onto the packing pocket in order to allow the envelope to be opened, characterized in that the packing pocket is arranged immovably during the inserting operation.
A wound dressing apparatus for use in a topical negative pressure system, comprising: a wound dressing comprising: a perforated wound contact layer; an absorbent layer for absorbing wound exudate; a lower liquid and gas permeable transmission layer underlying the absorbent layer; a liquid impermeable, gas permeable filter layer over the absorbent layer; a further liquid and gas permeable transmission layer between the filter layer and the absorbent layer; a cover layer comprising at least one orifice wherein, in use, a negative pressure is generated under the cover layer by a pump; wherein peripheral regions of the lower transmission layer and the further transmission layer are pinched together to provide fluid communication paths through which fluid can be transmitted from the lower transmission layer to the further transmission layer. a perforated wound contact layer; an absorbent layer for absorbing wound exudate; a lower liquid and gas permeable transmission layer underlying the absorbent layer; a liquid impermeable, gas permeable filter layer over the absorbent layer; a further liquid and gas permeable transmission layer between the filter layer and the absorbent layer; a cover layer comprising at least one orifice wherein, in use, a negative pressure is generated under the cover layer by a pump; wherein peripheral regions of the lower transmission layer and the further transmission layer are pinched together to provide fluid communication paths through which fluid can be transmitted from the lower transmission layer to the further transmission layer.
Closure unit for a lock, comprising an actuator for moving or for blocking and releasing a locking and unlocking unit of the lock, an electrical power supply arrangement, a switch between the electrical power supply arrangement and the actuator, an encryption/decryption unit, a key memory and a basic passive RFID circuit having an antenna, wherein the closure unit is suppliable with electrical energy exclusively via an RFID reader, wherein the energy transfer from the RFID reader to the closure unit is effected by means of induction, wherein the electrical power supply arrangement comprises at least one electrical short-term energy buffer, which is in the form of a capacitor, for storing the electrical energy transferred from the RFID reader to the closure unit, and wherein the closure unit uses a bidirectional communication connection between the RFID reader and the closure unit to receive a key from the RFID reader, which the RFID reader uses to authenticate itself to the closure unit, characterized in that at least the actuator, the switch between the electrical power supply arrangement and the actuator, the encryption/decryption unit and the key memory are arranged in a housing that cannot be opened non-destructively, which can be opened only by destroying it.