A composition comprising: (a) a biologically compatible structural component comprising a linear acrylic polymer, wherein the linear acrylic polymer is a linear acrylic homopolymer or linear acrylic copolymer having the structure: wherein (i) X is hydrogen or a methyl group; (ii) each of R and R 1 is independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; (iii) m is a positive integer; and (iv) n is 0 or a positive integer; and (b) a biobeneficial component comprising a copolymer having a biobeneficial moiety and an acrylate moiety, which copolymer is a random, block, graft or brush copolymer comprising: (i) at least one of and (ii) at least one of wherein (iii) X is hydrogen or a methyl group; (iv) R is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; and (v) Q is a fragment providing the copolymer with biobeneficial properties, wherein Q is derived from superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, or mixtures thereof, wherein the mass ratio between the structural component and the biobeneficial component is from 99:1 to 1:1; wherein the SODm is manganese dichloroaminoethyl thiolated pentaazatetracyclohexacosatriene (SOD-40470); wherein the diazenium diolate type nitric oxide donors are selected from N-{4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl}-diazen-1-ium-1,2-diolate, 1-{N-methyl-N-[6-(N-methylammonio)hexyl]amino}diazen-1-ium-1,2-diolate, and Z-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate; and wherein the polycationic peptides are selected from poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(δ-guanidino-α-aminobutyric acid), and a racemic mixture of poly(L-arginine) or poly(D-arginine). (a) a biologically compatible structural component comprising a linear acrylic polymer, wherein the linear acrylic polymer is a linear acrylic homopolymer or linear acrylic copolymer having the structure: wherein (i) X is hydrogen or a methyl group; (ii) each of R and R 1 is independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; (iii) m is a positive integer; and (iv) n is 0 or a positive integer; and (i) X is hydrogen or a methyl group; (ii) each of R and R 1 is independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; (iii) m is a positive integer; and (iv) n is 0 or a positive integer; and (b) a biobeneficial component comprising a copolymer having a biobeneficial moiety and an acrylate moiety, which copolymer is a random, block, graft or brush copolymer comprising: (i) at least one of and (ii) at least one of wherein (iii) X is hydrogen or a methyl group; (iv) R is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; and (v) Q is a fragment providing the copolymer with biobeneficial properties, wherein Q is derived from superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, or mixtures thereof, (i) at least one of and (ii) at least one of wherein (iii) X is hydrogen or a methyl group; (iv) R is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; and (v) Q is a fragment providing the copolymer with biobeneficial properties, wherein Q is derived from superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, or mixtures thereof, N-{4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl}-diazen-1-ium-1,2-diolate, 1-{N-methyl-N-[6-(N-methylammonio)hexyl]amino}diazen-1-ium-1,2-diolate, and Z-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate; and