A pharmaceutical composition comprising: (i) a compound of Formula 1 having the structure: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: X is selected from the group consisting of q is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, or 4; r is 0, 1, 2, 3, or 4; R 1 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -NO 2, -N(R')C C 1 -C 6 alkyl, -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); w is 0, 1 or 2; R' is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; R" is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; or R' and R" are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring; R 2 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); and R 3 is selected from the group consisting of -H and -C 1 -C 6 alkyl; wherein C 1 -C 6 alkyl or C 1 -C 6 alkoxy may be independently for each occurrence optionally substituted with one, two, or three halogens; and (ii) a pharmaceutically acceptable excipient. (i) a compound of Formula 1 having the structure: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: X is selected from the group consisting of q is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, or 4; r is 0, 1, 2, 3, or 4; R 1 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -NO 2, -N(R')C C 1 -C 6 alkyl, -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); w is 0, 1 or 2; R' is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; R" is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; or R' and R" are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring; R 2 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); and R 3 is selected from the group consisting of -H and -C 1 -C 6 alkyl; wherein C 1 -C 6 alkyl or C 1 -C 6 alkoxy may be independently for each occurrence optionally substituted with one, two, or three halogens; and X is selected from the group consisting of q is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, or 4; r is 0, 1, 2, 3, or 4; R 1 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -NO 2, -N(R')C C 1 -C 6 alkyl, -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); w is 0, 1 or 2; R' is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; R" is independently for each occurrence selected from the group consisting of -H and -C 1 -C 6 alkyl; or R' and R" are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring; R 2 is independently for each occurrence selected from the group consisting of -H, -C 1 -C 6 alkyl, -C 1 -C 6 alkoxy, -C 1 -C 6 alkyl-O-C 1 -C 6 alkyl, halogen, cyano, -OH, -C H, -CO 2 R',-C N(R')(R"), -C C 1 -C 6 alkyl, -N(R')(R"), -S w -C 1 -C 6 alkyl, -N(R')S w -C 1 -C 6 alkyl, and -S w -N(R')(R"); and R 3 is selected from the group consisting of -H and -C 1 -C 6 alkyl; wherein C 1 -C 6 alkyl or C 1 -C 6 alkoxy may be independently for each occurrence optionally substituted with one, two, or three halogens; and (ii) a pharmaceutically acceptable excipient.