mhurhangee/ep-ind-claims huggingface dataset:
A method of differentiating a pluripotent stem cell into a desired cell type, comprising any one of the following steps to: a step of adding a gene for a compound having an action of substantially removing or reducing an expression amount of a POU5F1 protein, a demethylase gene, and a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell, wherein the demethylase has an action of removing a methyl group of H3K27me3; a step of adding a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell, in which a compound having an action of substantially removing or reducing an expression amount of a POU5F1 protein is forcibly expressed, and a demethylase is forcibly expressed, wherein the demethylase has an action of removing a methyl group of H3K27me3; and a step of adding a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell in which an expression amount of a POU5F1 protein has been substantially removed or reduced and which has a histone in which H3K27me3 modification has been substantially removed or reduced. a step of adding a gene for a compound having an action of substantially removing or reducing an expression amount of a POU5F1 protein, a demethylase gene, and a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell, wherein the demethylase has an action of removing a methyl group of H3K27me3; a step of adding a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell, in which a compound having an action of substantially removing or reducing an expression amount of a POU5F1 protein is forcibly expressed, and a demethylase is forcibly expressed, wherein the demethylase has an action of removing a methyl group of H3K27me3; and a step of adding a transcription factor required for induction of differentiation into the desired cell type to a pluripotent stem cell in which an expression amount of a POU5F1 protein has been substantially removed or reduced and which has a histone in which H3K27me3 modification has been substantially removed or reduced.
A vehicle-to-implement hitch comprising a force transfer hitch connector adapted to provide a hitch point to which an implement can be connected, the hitch is movable between a stowed configuration and a deployed configuration and is deployable from a vehicle in use, wherein the hitch comprises at least one extendable actuator, characterised in that the hitch furthermore comprises at least two flexible tensioning members (5, 6), whereby the flexible tensioning members and the actuator respectively connect the hitch point to different positions on a vehicle, whereby in the deployed position the tensioning members assume a generally triangular configuration with the hitch point formed at an apex thereof, whereby the actuator when being fully extended and exposed to an overload is no longer fully extended.
A filling device comprising a storage tank for storing hydrogen fuel, a filling nozzle (10, 11) for filling hydrogen from the storage tank through a fuel filling system to an in-vehicle hydrogen filling tank mounted on a vehicle, and a roc having a valve element at an end, said rod slidably arranged against an elastic member in a pipe joint main body of the filling nozzle, characterised in that in an end portion of the pipe joint main body on a side of the in vehicle hydrogen filling tank, an innermost projecting portion for forming surface on which the rod slides projects on the side of the in-vehicle hydrogen filling tank, and when the filling nozzle (10, 11) is connected to a vehicle side filling port of the in-vehicle hydrogen filling tank, an outer surface of the projecting portion of the pipe joint main body contacts an inner surface of the vehicle side filling port.
An airless tire comprises a laminate body of a rubber layer and a resin layer made of a resin, wherein the rubber layer includes a surface-treated superficial layer directly united with the resin layer without any intervening adhesive layer, wherein the surface-treated superficial layer is a chlorinated layer.
A stent formed substantially as a tube which has a form in which a plurality of wavy annular members is arranged adjacently to each other in an axial direction of said stent with said adjacent wavy annular members connected with each other, has a diameter whose dimension is so set that said stent can be inserted into a lumen inside a living body, and can be expanded when a force spreading radially from an inside of said tube is applied to said stent, wherein said wavy annular member has parallel straight-line portions extended in parallel with an axis of said stent before and after said stent expands; and said stent has connection portions each connecting opposed ends of said parallel straight-line portions of said adjacent wavy annular members to each other, wherein two parallel straight-line portions connected to each other with said connection portion are almost aligned to each other, characterized in that there are two connection portions connecting adjacent wavy annular members to each other, wherein the connecting portions are provided at opposed positions, wherein said connection portions adjacent to each other in said axial direction of said stent are shifted from each other in a direction orthogonal to said axis of said stent, wherein said wavy annular member includes a plurality of modified M-shaped linear portions, continuous with each other, each of which has four linear portions composed of said parallel straight-line portion, a first inclined straight-line portion which is connected with one end of said parallel straight-line portion through a bent portion and becomes oblique to said axis of said stent at a predetermined angle at least when said stent expands, an inclined curved line portion which is connected with one end of said first inclined straight-line portion through a bent portion and extended obliquely at a predetermined angle to said axis of said stent, and a second inclined straight-line portion connected with one end of said inclined curved line portion through a bent portion and becomes oblique to said axis of said stent at a predetermined angle at least when said stent expands.
A transmission for an electric miniature drive or microdrive, having a transmission housing in which a transmission mechanism is disposed, an attachment flange for attaching the transmission to an application, a driven shaft for driving the application, which driven shaft is supported in at least one driven bearing, wherein the driven shaft is configured connectable via the transmission mechanism to the miniature or microdrive, and a torque measuring member for the registration of the torque generated on the driven shaft by means of a flexible element during operation of the miniature drive or microdrive, characterized in that on the flexible element, a magnetic encoder system is disposed having a magnetic field generating element and a magnetic field measuring element for measuring a rotatory displacement of the flexible element, wherein the flexible element is disposed axially between the transmission mechanism and the attachment flange and the flexible element comprises at least three struts extending axially parallel to the driven shaft and the struts of the flexible element have a radial height that is at least twice as large as the tangential thickness, and have an axial length that is at least four times as large as the tangential thickness, and the magnetic field generating element is disposed in the intermediate space of the struts on the elastic element spaced apart from the magnetic field measuring element, wherein the magnetic field generating element is disposed on a first partial element of the flexible element, which first partial element is connected to a first axial extremity of the flexible element, and the magnetic field measuring element is disposed on a second partial element of the flexible element, which second partial element is connected to an opposing second axial extremity of the flexible element.
A method for producing solid lubricant agglomerates (42, 48) comprising: admixing particulate solid lubricant, an inorganic binder, and water to produce a mixture having about 5 to 60 weight % solids based on the total weight of the mixture, wherein the ratio of the weight of the solid lubricant being admixed to the weight of the binder being admixed is from about 19:1 to about 1: 19; drying the mixture to produce dry agglomerates; classifying the dry agglomerates by size, or milling and classifying the dry agglomerates by size, into an under-size particle fraction, an on-size particle fraction (42, 48) and an over-size particle fraction, wherein the under-size particle fraction is reprocessed by re-dispersing in the water, and wherein the over-size particle fraction is either reprocessed by re-dispersing in the water, or by crushing and recovering the particles that are in the on-size particle fraction (42, 48), characterized in that the inorganic binder is a hydrous aluminium silicate permitting reversible dehydration allowing dispersion of the under-size and over-size particles in the water. admixing particulate solid lubricant, an inorganic binder, and water to produce a mixture having about 5 to 60 weight % solids based on the total weight of the mixture, wherein the ratio of the weight of the solid lubricant being admixed to the weight of the binder being admixed is from about 19:1 to about 1: 19; drying the mixture to produce dry agglomerates; classifying the dry agglomerates by size, or milling and classifying the dry agglomerates by size, into an under-size particle fraction, an on-size particle fraction (42, 48) and an over-size particle fraction, wherein the under-size particle fraction is reprocessed by re-dispersing in the water, and wherein the over-size particle fraction is either reprocessed by re-dispersing in the water, or by crushing and recovering the particles that are in the on-size particle fraction (42, 48), characterized in that the inorganic binder is a hydrous aluminium silicate permitting reversible dehydration allowing dispersion of the under-size and over-size particles in the water.
A method for producing a prosthesis (5,6,8,10;30;40;50;60;70;80) containing zirconia and for supplementing a defective portion of a natural bone, comprising: a γ-ray sterilization treatment of the prosthesis containing zirconia at the volume ratio of 50% or more, characterized in that the method further comprises: a heat treatment after the γ-ray sterilization treatment, thereby changing a color approximate to that of the natural bone, wherein the color approximate to that of the natural bone has an L* value of 60 to 90, an a* value of -5 to 10, and b* value of -5 to 10 in the L*a*b* color space, and the heat treatment has a highest temperature of 100°C to 300°C. a γ-ray sterilization treatment of the prosthesis containing zirconia at the volume ratio of 50% or more, characterized in that the method further comprises: a heat treatment after the γ-ray sterilization treatment, thereby changing a color approximate to that of the natural bone, wherein the color approximate to that of the natural bone has an L* value of 60 to 90, an a* value of -5 to 10, and b* value of -5 to 10 in the L*a*b* color space, and the heat treatment has a highest temperature of 100°C to 300°C. a heat treatment after the γ-ray sterilization treatment, thereby changing a color approximate to that of the natural bone, wherein the color approximate to that of the natural bone has an L* value of 60 to 90, an a* value of -5 to 10, and b* value of -5 to 10 in the L*a*b* color space, and the heat treatment has a highest temperature of 100°C to 300°C.
A geometrically transformable vacuum assisted infusion casting mould for producing an infusion-moulded reinforced composite article, the mould comprising - at least two movable mould walls (10, 11, 12, 26, 27, 50-57) defining a mould space, a mould surface and an opening to the mould space, the mould walls being positionable to provide a desired shape for the object to be moulded, wherein the contour formed by the mould walls define at least a partial outer surface or inner surface of the composite structure to be moulded, two mould walls being connected to each other by a junction, - a vacuum bag sealable to the mould and forming a vacuum space with the mould when sealed, - means for introducing vacuum into the vacuum space, and - sealing means located at each junction of the two mould walls (10, 11, 12, 26, 27, 50-57), such as butt junction, the material of the sealing means being flexible and the sealing means being arranged to seal the junction when vacuum is applied into the vacuum space, wherein the sealing means are elongated substantially flat pieces comprising elastic material, such as elastomeric or plastomeric material, wherein the sealing means are located on the other side of the mould than the vacuum space and the flexible material of the sealing means is arranged to be pressed by the suction of the inside vacuum to the junction of the two mould walls to air-tightly seal the junction. - at least two movable mould walls (10, 11, 12, 26, 27, 50-57) defining a mould space, a mould surface and an opening to the mould space, the mould walls being positionable to provide a desired shape for the object to be moulded, wherein the contour formed by the mould walls define at least a partial outer surface or inner surface of the composite structure to be moulded, two mould walls being connected to each other by a junction, - a vacuum bag sealable to the mould and forming a vacuum space with the mould when sealed, - means for introducing vacuum into the vacuum space, and - sealing means located at each junction of the two mould walls (10, 11, 12, 26, 27, 50-57), such as butt junction, the material of the sealing means being flexible and the sealing means being arranged to seal the junction when vacuum is applied into the vacuum space, wherein the sealing means are elongated substantially flat pieces comprising elastic material, such as elastomeric or plastomeric material, wherein the sealing means are located on the other side of the mould than the vacuum space and the flexible material of the sealing means is arranged to be pressed by the suction of the inside vacuum to the junction of the two mould walls to air-tightly seal the junction.
A transformer for reducing eddy current losses of a coil, the transformer comprising: a core; and a first coil and a second coil sequentially installed on concentric circles surrounding the core, wherein each of the first coil and the second coil comprises a plurality of conductors, characterized in that: each of a first outer upper end and a first outer lower end of the first coil and a second inner upper end and a second inner lower end of the second coil has a cut part by removed conductors, and wherein an insulating material is disposed in the cut part, thereby reducing an influence of leakage flux. a core; and a first coil and a second coil sequentially installed on concentric circles surrounding the core, wherein each of the first coil and the second coil comprises a plurality of conductors, characterized in that: each of a first outer upper end and a first outer lower end of the first coil and a second inner upper end and a second inner lower end of the second coil has a cut part by removed conductors, and wherein an insulating material is disposed in the cut part, thereby reducing an influence of leakage flux. each of a first outer upper end and a first outer lower end of the first coil and a second inner upper end and a second inner lower end of the second coil has a cut part by removed conductors, and wherein an insulating material is disposed in the cut part, thereby reducing an influence of leakage flux.
A toy building set comprising at least one first type of building element, on which a rotation shaft located along an axis of rotation is arranged, and wherein the toy building set comprises at least one second type of building (5, 6) element in which a rotation bushing (10, 11) is provided which is configured for receiving and being interconnected with the rotation shaft on the first building element in such a manner that the two building elements can rotate relative to each other about the axis of rotation; and wherein, at the rotation shaft and the rotation bushing (10, 11), respectively, complementary coupling means (4, 13, 14) are configured for forming a snap connection for interconnection of the rotation shaft and the rotation bushing (10, 11) in such a manner that they cannot be interconnected with or disconnected from each other along the axis of rotation without the complementary coupling means (4, 13, 14) being activated by a given force impact along the axis of rotation, characterised in that the toy building set comprises at least one third type of building element, said building element comprising a rotation shaft or a rotation bushing which has respective complementary coupling means for forming a snap connection for interconnection of the third type of building element to the rotation bushing or the rotation shaft on the second or the first type of building element, respectively; and wherein the complementary coupling means on the third type of building element are configured such that it requires a smaller force impact to mount the third type of building element on the first or the second type of building element, respectively, than the force needed to interconnect the first type of building element to the second type (5, 6) of building element.
A process for the conversion of ethylene oxide to 2-aminoethanol and ethane-1,2-diamine comprising (i) providing a catalyst comprising a zeolitic material comprising YO 2 and X 2 O 3, wherein Y is a tetravalent element and X is a trivalent element; (ii) providing a gas stream comprising ethylene oxide and ammonia; (iii) contacting the catalyst provided in (i) with the gas stream provided in (ii) for converting ethylene oxide to 2-aminoethanol and ethane-1,2-diamine, wherein in (i) the zeolitic material has the MOR framework structure. (i) providing a catalyst comprising a zeolitic material comprising YO 2 and X 2 O 3, wherein Y is a tetravalent element and X is a trivalent element; (ii) providing a gas stream comprising ethylene oxide and ammonia; (iii) contacting the catalyst provided in (i) with the gas stream provided in (ii) for converting ethylene oxide to 2-aminoethanol and ethane-1,2-diamine,
A compound of Formula wherein, R 1 = wherein R 1a = H or -CH 3 or R 1 = wherein D = deuterium; R 2 = H and R 3 = H; R 4 = H, and R 5 = -CH 3 or -CH 2 OH; or R 4 = -CH 2 OH, and R 5 = H; or R 2 = -CH 3, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH or -CH 2 OC H; R 3 = H; R 4 = -CH 3, -CH 2 OH, -CH 2 CH 2 OH, -CH 2 CH CH 3 or -CH 2 C (CH 3) 2 and R 5 = H, or R 4 = H, and R 5 = -CH 3, -CH 2 OH, -CH 2 CH CH 3 or -CH 2 C (CH 3) 2, or R 4 = H or -CH 3 and R 5 = H or -CH 3; or R 3 = H and R 4 = H; R 2 and R 5 are joined and form -(CH 2) 4 -; or R 4 = H and R 5 = H; and R 2 = -CH 2 OH, and R 3 = -CH 3; or R 2 = H or -CH 3, and R 3 = -CH 2 OH; or R 2 = H and R 4 = H; and R 3 and R 5 are joined and form the group or the group or R 3 = H and R 5 = H; and R 2 and R 4 are joined and form the group or a pharmaceutically acceptable salt thereof. R 1 = wherein R 1a = H or -CH 3 or R 1 = wherein D = deuterium; R 2 = H and R 3 = H; R 4 = H, and R 5 = -CH 3 or -CH 2 OH; or R 4 = -CH 2 OH, and R 5 = H; R 2 = -CH 3, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH or -CH 2 OC H; R 3 = H; R 4 = -CH 3, -CH 2 OH, -CH 2 CH 2 OH, -CH 2 CH CH 3 or -CH 2 C (CH 3) 2 and R 5 = H, or R 4 = H, and R 5 = -CH 3, -CH 2 OH, -CH 2 CH CH 3 or -CH 2 C (CH 3) 2, or R 4 = H or -CH 3 and R 5 = H or -CH 3; R 3 = H and R 4 = H; R 2 and R 5 are joined and form -(CH 2) 4 -; R 4 = H and R 5 = H; and R 2 = -CH 2 OH, and R 3 = -CH 3; or R 2 = H or -CH 3, and R 3 = -CH 2 OH; R 2 = H and R 4 = H; and R 3 and R 5 are joined and form the group or the group R 3 = H and R 5 = H; and R 2 and R 4 are joined and form the group or a pharmaceutically acceptable salt thereof.
A packaging bag (10; 110; 210) of flexible material closed at one end by means of a seal to form a header (16; 116; 216), in which the header comprises a removable outer header portion (16B; 116B) and an inner header portion (16A; 116A) both of which are sealed, the seal in the inner header portion (16A, 116A) being a peelable seal, the outer header portion (16B; 116B) defining an oval aperture (28; 128) by means of which the packaging can be suspended for display purposes, the aperture (28; 128; 228) being dimensioned to enable the insertion of one or more fingers and offset proximal to a first side edge (24; 124) of the outer header portion, wherein the oval aperture (28; 128; 228) has a major axis and a minor axis; characterised in that the aperture is aligned so that its major axis extends at an angle of between 30 to 60 degrees relative to the longitudinal axis of the bag downwardly in a direction towards the first side edge (24; 124) when the header (16; 116; 216) is uppermost.
An apparatus comprising a first frame, a further frame, a first element, a second element and a third element; wherein a) the first frame frames the further frame; b) the further frame i) frames the first element, and ii) electrically insulated the first element and the first frame from each other; c) the first element is electrically conductive; d) the second element is electrically conductive; and e) the third element provides an electrically conductive connection between the first element and the second element; characterized in that said third element has a porosity in a range of 0.001 to 0.4. a) the first frame frames the further frame; b) the further frame i) frames the first element, and ii) electrically insulated the first element and the first frame from each other; i) frames the first element, and ii) electrically insulated the first element and the first frame from each other; c) the first element is electrically conductive; d) the second element is electrically conductive; and e) the third element provides an electrically conductive connection between the first element and the second element;