A manufacturing method of an organic light emitting diode array substrate, the organic light emitting diode array substrate comprising a thin film transistor and an organic light emitting diode, the method comprising steps of: forming an oxide semiconductor layer by a film forming process, and performing one patterning process on the oxide semiconductor layer to form an active layer of the thin film transistor and a first electrode of the organic light emitting diode; forming a gate insulating layer on the active layer of the thin film transistor, the first electrode of the organic light emitting diode, and a part of a base substrate that is not covered by the active layer of the thin film transistor and the first electrode of the organic light emitting diode; forming a gate on the gate insulating layer; sequentially forming a first insulating layer and a second insulating layer on the active layer and the first electrode of the organic light emitting diode, the first insulating layer being a lyophilic layer, and the second insulating layer being a lyophobic layer; forming an accommodation cavity exposing the first electrode by performing a patterning process on the first insulating layer and the second insulating layer; and injecting a solution containing an organic light emitting material into the accommodation cavity and performing a drying process to form an organic light emitting material layer, wherein after forming the first insulating layer and before forming the second insulating layer, the method further comprises a step of: forming a source and a drain on the first insulating layer such that the source and the drain are respectively electrically connected to the active layer through a first via hole and a second via hole penetrating through the first insulating layer and the gate insulating layer, and the drain is further electrically connected to the first electrode of the organic light emitting diode through a third via hole penetrating through the first insulating layer and the gate insulating layer, and wherein in the step of forming an accommodation cavity exposing the first electrode by performing a patterning process on the first insulating layer and the second insulating layer, the patterning process is performed on the first insulating layer, the second insulating layer and the gate insulating layer to form the accommodation cavity exposing the first electrode, the gate insulating layer has lyophilic property. forming an oxide semiconductor layer by a film forming process, and performing one patterning process on the oxide semiconductor layer to form an active layer of the thin film transistor and a first electrode of the organic light emitting diode; forming a gate insulating layer on the active layer of the thin film transistor, the first electrode of the organic light emitting diode, and a part of a base substrate that is not covered by the active layer of the thin film transistor and the first electrode of the organic light emitting diode; forming a gate on the gate insulating layer; sequentially forming a first insulating layer and a second insulating layer on the active layer and the first electrode of the organic light emitting diode, the first insulating layer being a lyophilic layer, and the second insulating layer being a lyophobic layer; forming an accommodation cavity exposing the first electrode by performing a patterning process on the first insulating layer and the second insulating layer; and injecting a solution containing an organic light emitting material into the accommodation cavity and performing a drying process to form an organic light emitting material layer, wherein after forming the first insulating layer and before forming the second insulating layer, the method further comprises a step of: forming a source and a drain on the first insulating layer such that the source and the drain are respectively electrically connected to the active layer through a first via hole and a second via hole penetrating through the first insulating layer and the gate insulating layer, and the drain is further electrically connected to the first electrode of the organic light emitting diode through a third via hole penetrating through the first insulating layer and the gate insulating layer, and wherein in the step of forming an accommodation cavity exposing the first electrode by performing a patterning process on the first insulating layer and the second insulating layer, the patterning process is performed on the first insulating layer, the second insulating layer and the gate insulating layer to form the accommodation cavity exposing the first electrode, the gate insulating layer has lyophilic property. forming a source and a drain on the first insulating layer such that the source and the drain are respectively electrically connected to the active layer through a first via hole and a second via hole penetrating through the first insulating layer and the gate insulating layer, and the drain is further electrically connected to the first electrode of the organic light emitting diode through a third via hole penetrating through the first insulating layer and the gate insulating layer, and wherein in the step of forming an accommodation cavity exposing the first electrode by performing a patterning process on the first insulating layer and the second insulating layer, the patterning process is performed on the first insulating layer, the second insulating layer and the gate insulating layer to form the accommodation cavity exposing the first electrode, the gate insulating layer has lyophilic property.