A compound of formula I or pharmaceutically acceptable salts, hydrates or solvates thereof, wherein: P is F or H; X is O, S, NH or NCH 3; Z is N or CH; Y is N or CH; n is an integer between 1 and 6; R 1 and R 2, which are same or different, are selected independently from the group consisting of H, (C 1 -C 10) alkyl, (C 3 -C 7) cycloalkyl, (C 2 -C 10)alkenyl and (C 2 -C 10)alkynyl, wherein said alkyl, cycloalkyl, alkenyl and alkynyl are optionally substituted with 1 to 3 same or different R 4; or R 1 and R 2 are covalently bonded together with the nitrogen to which they are attached to form 5- to 10-membered heterocyclic radical or 5- to 10-membered heteroaryl radical, said heterocyclic radical or heteroaryl radical may have optionally 1 to 4 heteroatoms selected from N, O or S except the nitrogen atom to which R 1 and R 2 are attached, said heterocyclic radical may optionally have 1 to 2 carbon-carbon double bond or triple bond, said heterocyclic and heteroaryl radicals can be optionally substituted with 1 to 3 same or different R 4; R 4 is (C 1 -C 4) alkyl, (C 1 -C 4)alkoxyl, halogen, hydroxyl, cyano, carboxyl, ester group; R 3 is hydrogen or 1 to 3 substituents selected independently from the group consisting of hydroxyl, halogen, nitro, amino, cyano, (C 1 -C 6) alkyl, (C 1 -C 6)alkenyl, (C 1 -C 6) alkynyl, (C 1 -C 6) alkoxyl, (C 1 -C 6) alkylsulfanyl, (C 1 -C 6) alkyl or (C 1 -C 6) alkoxyl or (C 1 -C 6) alkylsulfanyl substituted optionally with hydroxyl, amino or halogen, amino substituted with 1 or 2 (C 1 -C 6) alkyl, (C 1 -C 6)alkylamido, carboxy group which can be free, salts, or form ester group, (C 1 -C 6) alkylsulfinyl, sulfonyl,(C 1 -C 6)alkylacyl, aminoformyl, aminoformyl substituted with 1 or 2 (C 1 -C 6)alkyl,(C 1 -C 3)alkylenedioxo; Ar represents (C 6 -C 10)aryl, 5- to 10-membered heteroaryl radical, wherein said heteroaryl radical may have 1 to 3 heteroatom(s) selected from N, O or S and Ar can be optionally substituted with 1 to 3 same or different R 5; R 5 is hydroxyl, halogen, nitro, amino, cyano, (C 1 -C 6) alkyl, (C 1 -C 6)alkenyl, (C 1 -C 6) alkynyl, (C 1 -C 6) alkoxyl,(C 1 -C 6) alkyl or (C 1 -C 6) alkoxyl optionally substituted with hydroxyl, amino or halogen,amino substituted with 1 or 2 (C 1 -C 6) alkyl, carboxy group which can be free, salts, or form ester group;(C 1 -C 6) alkylsulfinyl, sulfonyl, (C 1 -C 6) alkoxyl (C 1 -C 6) alkyl, (C 1 -C 6)alkylacyl, aminoformyl, aminoformyl substituted optionally with 1 or 2 (C 1 -C 6) alkyl,(C 1 -C 3)alkylenedioxo. P is F or H; X is O, S, NH or NCH 3; Z is N or CH; Y is N or CH; n is an integer between 1 and 6; R 1 and R 2, which are same or different, are selected independently from the group consisting of H, (C 1 -C 10) alkyl, (C 3 -C 7) cycloalkyl, (C 2 -C 10)alkenyl and (C 2 -C 10)alkynyl, wherein said alkyl, cycloalkyl, alkenyl and alkynyl are optionally substituted with 1 to 3 same or different R 4; or R 1 and R 2 are covalently bonded together with the nitrogen to which they are attached to form 5- to 10-membered heterocyclic radical or 5- to 10-membered heteroaryl radical, said heterocyclic radical or heteroaryl radical may have optionally 1 to 4 heteroatoms selected from N, O or S except the nitrogen atom to which R 1 and R 2 are attached, said heterocyclic radical may optionally have 1 to 2 carbon-carbon double bond or triple bond, said heterocyclic and heteroaryl radicals can be optionally substituted with 1 to 3 same or different R 4; R 4 is (C 1 -C 4) alkyl, (C 1 -C 4)alkoxyl, halogen, hydroxyl, cyano, carboxyl, ester group; R 3 is hydrogen or 1 to 3 substituents selected independently from the group consisting of hydroxyl, halogen, nitro, amino, cyano, (C 1 -C 6) alkyl, (C 1 -C 6)alkenyl, (C 1 -C 6) alkynyl, (C 1 -C 6) alkoxyl, (C 1 -C 6) alkylsulfanyl, (C 1 -C 6) alkyl or (C 1 -C 6) alkoxyl or (C 1 -C 6) alkylsulfanyl substituted optionally with hydroxyl, amino or halogen, amino substituted with 1 or 2 (C 1 -C 6) alkyl, (C 1 -C 6)alkylamido, carboxy group which can be free, salts, or form ester group, (C 1 -C 6) alkylsulfinyl, sulfonyl,(C 1 -C 6)alkylacyl, aminoformyl, aminoformyl substituted with 1 or 2 (C 1 -C 6)alkyl,(C 1 -C 3)alkylenedioxo; Ar represents (C 6 -C 10)aryl, 5- to 10-membered heteroaryl radical, wherein said heteroaryl radical may have 1 to 3 heteroatom(s) selected from N, O or S and Ar can be optionally substituted with 1 to 3 same or different R 5; R 5 is hydroxyl, halogen, nitro, amino, cyano, (C 1 -C 6) alkyl, (C 1 -C 6)alkenyl, (C 1 -C 6) alkynyl, (C 1 -C 6) alkoxyl,(C 1 -C 6) alkyl or (C 1 -C 6) alkoxyl optionally substituted with hydroxyl, amino or halogen,amino substituted with 1 or 2 (C 1 -C 6) alkyl, carboxy group which can be free, salts, or form ester group;(C 1 -C 6) alkylsulfinyl, sulfonyl, (C 1 -C 6) alkoxyl (C 1 -C 6) alkyl, (C 1 -C 6)alkylacyl, aminoformyl, aminoformyl substituted optionally with 1 or 2 (C 1 -C 6) alkyl,(C 1 -C 3)alkylenedioxo.