A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof, wherein: W is O; X is C-H; Y is C-R 3; R 1 is selected from C 1-6 alkyl, 3- to 5-membered carbocyclyl, 5- or 6-membered heterocyclyl, -OR 1a, -SR 1a, -N(R 1a) 2, -N(R 1a)C R 1b, -C R 1b, -C 2 R 1a, -C N(R 1a) 2, -C N(R 1a)(OR 1a) and -S 2 R 1b, wherein said C 1-6 alkyl, 3 to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl are optionally substituted on carbon with one or more R 10, and wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R 10*; R 1a in each occurrence is independently selected from H, C 1-6 alkyl, 3- to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl, wherein said C 1-6 alkyl, 3- to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl in each occurrence are optionally and independently substituted with one or more R 10, wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R 10*; R 1b in each occurrence is independently selected from C 1-6 alkyl and 4- to 6-membered heterocyclyl, wherein said C 1-6 alkyl and 4- to 6-membered heterocyclyl are optionally and independently substituted on carbon with one or more R 10, and wherein any -NH- moiety of said 4- to 6-membered heterocyclyl is optionally substituted with R 10*; R 3 is halo; R 10 in each occurrence is independently selected from halo, -CN, C 1-6 alkyl, 3- to 6-membered carbocyclyl, 5- or 6-membered heterocyclyl, -OR 10a, -SR 10a, -N(R 10a) 2, -N(R 10a)C R 10b, -C 2 R 10a, -C N(R 10a) 2, wherein said C 1-6 alkyl, 3- to 6-membered carbocyclyl, and 5- or 6-membered heterocyclyl in each occurrence are optionally substituted with one or more R a, and wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R a*; R 10* in each occurrence is independently selected from C 1-6 alkyl and -C R 10b; R 10a in each occurrence is independently selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl in each occurrence is optionally and independently substituted with one or more R a; R 10b is C 1-6 alkyl; R a in each occurrence is independently selected from halo, -CN, and -OR m; R a* is C 1-6 alkyl; and R m in each occurrence is independently selected from H and C 1-6 alkyl. W is O; X is C-H; Y is C-R 3; R 1 is selected from C 1-6 alkyl, 3- to 5-membered carbocyclyl, 5- or 6-membered heterocyclyl, -OR 1a, -SR 1a, -N(R 1a) 2, -N(R 1a)C R 1b, -C R 1b, -C 2 R 1a, -C N(R 1a) 2, -C N(R 1a)(OR 1a) and -S 2 R 1b, wherein said C 1-6 alkyl, 3 to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl are optionally substituted on carbon with one or more R 10, and wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R 10*; R 1a in each occurrence is independently selected from H, C 1-6 alkyl, 3- to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl, wherein said C 1-6 alkyl, 3- to 5-membered carbocyclyl, and 5- or 6-membered heterocyclyl in each occurrence are optionally and independently substituted with one or more R 10, wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R 10*; R 1b in each occurrence is independently selected from C 1-6 alkyl and 4- to 6-membered heterocyclyl, wherein said C 1-6 alkyl and 4- to 6-membered heterocyclyl are optionally and independently substituted on carbon with one or more R 10, and wherein any -NH- moiety of said 4- to 6-membered heterocyclyl is optionally substituted with R 10*; R 3 is halo; R 10 in each occurrence is independently selected from halo, -CN, C 1-6 alkyl, 3- to 6-membered carbocyclyl, 5- or 6-membered heterocyclyl, -OR 10a, -SR 10a, -N(R 10a) 2, -N(R 10a)C R 10b, -C 2 R 10a, -C N(R 10a) 2, wherein said C 1-6 alkyl, 3- to 6-membered carbocyclyl, and 5- or 6-membered heterocyclyl in each occurrence are optionally substituted with one or more R a, and wherein any -NH- moiety of said 5- or 6-membered heterocyclyl is optionally substituted with R a*; R 10* in each occurrence is independently selected from C 1-6 alkyl and -C R 10b; R 10a in each occurrence is independently selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl in each occurrence is optionally and independently substituted with one or more R a; R 10b is C 1-6 alkyl; R a in each occurrence is independently selected from halo, -CN, and -OR m; R a* is C 1-6 alkyl; and R m in each occurrence is independently selected from H and C 1-6 alkyl.