A compound of Formula IV: or a pharmaceutically acceptable salt or solvate thereof, wherein, independently for each occurrence, W is R 1 is Y is C 2 -C 20 alkylene or C 2 -C 20 heteroalkylene; C 3 -C 8 carbocyclo-, -arylene-, -C 3 -Csheterocyclo-, -C 1 -C 10 alkylene-arylene-, -arylene-C 1 -C 10 alkylene-, -C 1 -C 10 alkylene-(C 3 -Cscarbocyclo)-, -(C 3 -C 8 carbocyclo)-C 1 -C 10 alkylene-, -C 1 -Cioalkylene-(C 3 -C 8 heterocyclo)-, or - (C 3 -C 8 heterocyclo)-C 1 -C 10 alkylene-; Z" is Z'" is R 2 is hydrogen, C 1 -C 8 alkyl or C 1 -C 8 haloalkyl; R 3A and R 3B are defined as either of the following: (i) R 3A is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; and R 3B is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; or (ii) R 3A and R 3B taken together are C 2 -C 8 alkylene or C 1 -C 8 heteroalkylene; R 5 is C 1 -C 10 heterocyclyl, C 3 -C 8 carbocycly and C 6 -C 14 aryl optionally substituted with 1, 2, 3, 4 or 5 groups independently selected from the group consisting of -C 1 -C 8 alkyl, -C 1 -C 8 alkyl-N(R') 2, -C 1 -C 8 alkyl-C R', -C 1 -C 8 alkyl-C OR', -O-(C 1 -C 8 alkyl), - C R', -OC R', -C OR', -C N(R') 2, -NHC R', -S 2 R', -S R', -OH, halogen, -N 3, -N(R') 2, -CN, -NHC(=NH)NH 2, -NHCONH 2, -S(=O) 2 R' and -SR', wherein each R' is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl and unsubstituted aryl, or two R' can, together with the nitrogen to which they are attached, form a C 1 -C 10 heterocyclyl]; or R 5 is optionally substituted with 1, 2, 3, 4 or 5 groups independently selected from the group consisting of C 1 -C 8 alkyl, -C 1 -C 8 alkyl-N(R') 2, -C 1 -C 8 alkyl-C R', -C 1 -C 8 alkyl-C OR', -O-(C 1 -C 8 alkyl), -C R', -OC R', - C OR', -C N(R') 2, -NHC R', -S 2 R', -S R', -OH, halogen, -N 3, -N(R') 2, -CN, -NHC(=NH)NH 2, -NHCONH 2, -S(=O) 2 R', -SR' and arylene-R', wherein each R' is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, and aryl, or two R' can, together with the nitrogen to which they are attached, form a C 1 -C 10 heterocyclyl]; R 6 is hydrogen, -C 1 -C 8 alkyl, -C 2 -C 8 alkenyl, -C 2 -C 8 alkynyl or -C 1 -C 8 haloalkyl; R 12 is hydrogen, C 1 -C 4 alkyl, C 1 -C 10 heterocyclyl or C 6 -C 14 aryl; R 13 is C 1 -C 10 heterocyclyl; and X is O. W is R 1 is Y is C 2 -C 20 alkylene or C 2 -C 20 heteroalkylene; C 3 -C 8 carbocyclo-, -arylene-, -C 3 -Csheterocyclo-, -C 1 -C 10 alkylene-arylene-, -arylene-C 1 -C 10 alkylene-, -C 1 -C 10 alkylene-(C 3 -Cscarbocyclo)-, -(C 3 -C 8 carbocyclo)-C 1 -C 10 alkylene-, -C 1 -Cioalkylene-(C 3 -C 8 heterocyclo)-, or - (C 3 -C 8 heterocyclo)-C 1 -C 10 alkylene-; Z" is Z'" is R 2 is hydrogen, C 1 -C 8 alkyl or C 1 -C 8 haloalkyl; R 3A and R 3B are defined as either of the following: (i) R 3A is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; and R 3B is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; or (ii) R 3A and R 3B taken together are C 2 -C 8 alkylene or C 1 -C 8 heteroalkylene; R 5 is C 1 -C 10 heterocyclyl, C 3 -C 8 carbocycly and C 6 -C 14 aryl optionally substituted with 1, 2, 3, 4 or 5 groups independently selected from the group consisting of -C 1 -C 8 alkyl, -C 1 -C 8 alkyl-N(R') 2, -C 1 -C 8 alkyl-C R', -C 1 -C 8 alkyl-C OR', -O-(C 1 -C 8 alkyl), - C R', -OC R', -C OR', -C N(R') 2, -NHC R', -S 2 R', -S R', -OH, halogen, -N 3, -N(R') 2, -CN, -NHC(=NH)NH 2, -NHCONH 2, -S(=O) 2 R' and -SR', wherein each R' is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl and unsubstituted aryl, or two R' can, together with the nitrogen to which they are attached, form a C 1 -C 10 heterocyclyl]; (i) R 3A is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; and R 3B is C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 3 -C 8 carbocyclyl, or halogen; or (ii) R 3A and R 3B taken together are C 2 -C 8 alkylene or C 1 -C 8 heteroalkylene; R 5 is C 1 -C 10 heterocyclyl, C 3 -C 8 carbocycly and C 6 -C 14 aryl optionally substituted with 1, 2, 3, 4 or 5 groups independently selected from the group consisting of -C 1 -C 8 alkyl, -C 1 -C 8 alkyl-N(R') 2, -C 1 -C 8 alkyl-C R', -C 1 -C 8 alkyl-C OR', -O-(C 1 -C 8 alkyl), - C R', -OC R', -C OR', -C N(R') 2, -NHC R', -S 2 R', -S R', -OH, halogen, -N 3, -N(R') 2, -CN, -NHC(=NH)NH 2, -NHCONH 2, -S(=O) 2 R' and -SR', wherein each R' is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl and unsubstituted aryl, or two R' can, together with the nitrogen to which they are attached, form a C 1 -C 10 heterocyclyl]; or R 5 is optionally substituted with 1, 2, 3, 4 or 5 groups independently selected from the group consisting of C 1 -C 8 alkyl, -C 1 -C 8 alkyl-N(R') 2, -C 1 -C 8 alkyl-C R', -C 1 -C 8 alkyl-C OR', -O-(C 1 -C 8 alkyl), -C R', -OC R', - C OR', -C N(R') 2, -NHC R', -S 2 R', -S R', -OH, halogen, -N 3, -N(R') 2, -CN, -NHC(=NH)NH 2, -NHCONH 2, -S(=O) 2 R', -SR' and arylene-R', wherein each R' is independently selected from the group consisting of hydrogen, C 1 -C 8 alkyl, and aryl, or two R' can, together with the nitrogen to which they are attached, form a C 1 -C 10 heterocyclyl]; R 6 is hydrogen, -C 1 -C 8 alkyl, -C 2 -C 8 alkenyl, -C 2 -C 8 alkynyl or -C 1 -C 8 haloalkyl; R 12 is hydrogen, C 1 -C 4 alkyl, C 1 -C 10 heterocyclyl or C 6 -C 14 aryl; R 13 is C 1 -C 10 heterocyclyl; and X is O.