mhurhangee/ep-ind-claims huggingface dataset:
Method of assessing circadian rhythm or circadian profile of a subject having cancer and assessing a timing of administration of a medicament to said subject having cancer, wherein said method comprises the steps of: • Providing at least three samples of saliva, more preferably four samples of saliva, from said subject, wherein said samples have been taken at different time points over the day; • Determining gene expression of the following genes in each of said samples: a. of at least two members of the core-clock network in each of said samples, in particular of at least two members of the following genes, of the groups comprising ARNTL (BMAL1), ARNTL2, CLOCK, PER1, PER2, PER3, NPAS2, CRY1, CRY2, NR1D1, NR1D2, RORA, RORB, RORC, in particular ARNTL (BMAL1) and PER2, and b. at least one gene involved in the metabolism of a medicament to be administered to said subject having cancer, and c. at least one drug target gene that is a target of the medicament to be administered, and • Assessing and predicting by means of a computational step based on said expression levels of said genes over the day the circadian rhythm of said subject and assessing a timing of administration of said medicament to said subject, comprising assessing the optimal time of administration of said medicament to said subject and/or assessing the non-optimal time of administration of said medicament to said subject. • Providing at least three samples of saliva, more preferably four samples of saliva, from said subject, wherein said samples have been taken at different time points over the day; • Determining gene expression of the following genes in each of said samples: a. of at least two members of the core-clock network in each of said samples, in particular of at least two members of the following genes, of the groups comprising ARNTL (BMAL1), ARNTL2, CLOCK, PER1, PER2, PER3, NPAS2, CRY1, CRY2, NR1D1, NR1D2, RORA, RORB, RORC, in particular ARNTL (BMAL1) and PER2, and b. at least one gene involved in the metabolism of a medicament to be administered to said subject having cancer, and c. at least one drug target gene that is a target of the medicament to be administered, and a. of at least two members of the core-clock network in each of said samples, in particular of at least two members of the following genes, of the groups comprising ARNTL (BMAL1), ARNTL2, CLOCK, PER1, PER2, PER3, NPAS2, CRY1, CRY2, NR1D1, NR1D2, RORA, RORB, RORC, in particular ARNTL (BMAL1) and PER2, and b. at least one gene involved in the metabolism of a medicament to be administered to said subject having cancer, and c. at least one drug target gene that is a target of the medicament to be administered, and • Assessing and predicting by means of a computational step based on said expression levels of said genes over the day the circadian rhythm of said subject and assessing a timing of administration of said medicament to said subject, comprising assessing the optimal time of administration of said medicament to said subject and/or assessing the non-optimal time of administration of said medicament to said subject.
An injection device including a needle protection system, said injection device including a delivery needle that is provided with a delivery orifice, said protection system comprising a removable needle guard that, in a non-dispensing position, is adapted to be arranged around said needle so as to protect and isolate said delivery orifice of said needle, said needle guard including a hollow lateral body and an isolator portion, at least said isolator portion being made of flexible material, said delivery orifice of the needle being poked into said isolator portion in the non-dispensing position, the device being characterized in that said needle guard includes at least one outwardly-radial projection, said protection system further comprising an outer cap that is provided with grip means (35, 35', 36; 38; 300) that are adapted to co-operate with said at least one radial projection of said needle guard, such that moving said outer cap in the longitudinal direction of said needle, away from said delivery orifice, removes said needle guard from the non-dispensing position, said at least one radial projection being arranged at the distal axial end of said needle guard, said at least one radial projection being formed on a rigid outer structure of said needle guard.
A device for performing a method for producing a ground fog as an effect, for example in the field of stage technology, comprising a fog machine evaporating a fog fluid, e.g. glycol-based, characterized in that a mixing zone formed as a mixing chamber (7, 13, 20) for mixing the fog with water droplets from an ultrasonic atomizer (3, 12, 18) is arranged downstream of the fog machine, wherein the mixing chamber (7, 13, 20) each has an inlet (9, 10) for the fog machine and for a forced air flow from a fan (2, 11, 19), and wherein the air flow and the fog in the mixing chamber (7, 13, 20) are guided via the ultrasonic atomiser (3, 12, 18) and via at least one impact wall (16, 21) arranged downstream for water separation.
Plastic part with an outer surface and an inner surface and with openings of the highest precision for accommodating an attachment which has to be inserted into the opening via an exact gap size, wherein the transition from the opening inner surface to the outer surface of the plastic part is in the form of a radius, while the transition from the opening inner surface to the inner surface of the plastic part is in the form of a cone, characterized in that the radius is stamped out.
An implant for insertion into a human or animal body, comprising at least one substrate made of a metallic material and a surface formed on the substrate, the surface being provided in whole or in part with a hard material coating, characterized in that the hard material coating comprises a basic layer of TiN or TiNbN applied to the surface by a PVD process and an outer layer of TiAIN applied to the basic layer by a PVD process, the basic layer having a layer thickness in a range of from 1 to 5 μm and the TiAIN outer layer having a layer thickness of from 1 to 6 μm.
An imaging method using a multifocal lens having a plurality of regions (12a, 12b, 12c), the plurality of regions having different focal lengths, the method comprising: a focusing state control step (S709, S714, S909, S914) of controlling a focusing state of the multifocal lens; and an imaging step (S710, S716, S910, S916) of obtaining an image of a subject (Q, Q1, Q2, Q3) in the controlled focusing state, wherein in the focusing state control step (S709, S714, S909, S914), the focusing state is controlled so that a main subject (Q, Q1) is focused via a region with a shortest required focusing time among the plurality of regions (12a, 12b, 12c) in response to a picture taking instruction (S702, S902). a focusing state control step (S709, S714, S909, S914) of controlling a focusing state of the multifocal lens; and an imaging step (S710, S716, S910, S916) of obtaining an image of a subject (Q, Q1, Q2, Q3) in the controlled focusing state, wherein in the focusing state control step (S709, S714, S909, S914), the focusing state is controlled so that a main subject (Q, Q1) is focused via a region with a shortest required focusing time among the plurality of regions (12a, 12b, 12c) in response to a picture taking instruction (S702, S902).
A voltage source including two electrically conductive terminals (101, 102) with an electrolyte between them, wherein said electrolyte is a mixture in which the main components in percent by weight are aluminium and silicon oxides, characterized in that said terminals (101, 102) are the same material, whereby the voltage source is arranged to operate as a secondary, i.e. rechargeable, battery.
A modified conjugated diene-based polymer, comprising a nitrogen atom, wherein a content of the nitrogen atom is 25 ppm by mass or more based on a total amount of the modified conjugated diene-based polymer, a Mooney stress-relaxation rate measured at 110°C is 0.45 or less, a modification percentage is 75% by mass or more, and the ratio of the first weight-average molecular weight to the first number-average molecular weight is 1.50 or more and 3.50 or less, wherein the first weight-average molecular weight is the weight-average molecular weight in terms of polystyrene determined by measurement with gel permeation chromatography and the first number-average molecular weight is the number-average molecular weight in terms of polystyrene determined by measurement with gel permeation chromatography.
A linear guide having a slider with slide surfaces, a rail with guide surfaces, wherein the slider is guided with its slide surfaces adapted to the guide surfaces in slidingly displaceable reciprocating manner in a displacement direction (v) at the guide surfaces of the rail, and a self-adjusting play reduction of the linear guide with at least one adjusting element, wherein the adjusting element is mounted in the slider in an adjustment direction (e) perpendicular to the displacement direction (v) of the slider and the slider has a receiving seat in which the adjusting element is guided in slidingly displaceable manner in the adjustment direction (e) characterised in that the receiving seat opens into an associated one of the adapted slide surfaces and in that the adjusting element has a further slide surface capable of forming a portion of said associated one of the adapted slide surfaces of the slider, wherein in order to reduce play said further slide surface projects by a corresponding amount (b) beyond said associated one of the adapted slide surfaces.
A method of making a stable concentrated dairy liquid, the method comprising: providing a starting dairy liquid containing lactose and dairy protein with casein protein and whey protein; concentrating the casein protein and depleting the whey protein and lactose from the starting dairy liquid to form a whey and lactose depleted concentrated dairy liquid with a ratio of the casein protein to the whey protein of at least 90:10 and less than 1 percent lactose; maintaining the starting dairy liquid prior to and during the concentrating at or below a temperature so that no cross-linking occurs between the casein protein and the whey protein; adding a stabilizer and a mouthfeel enhancer to the whey and lactose depleted concentrated dairy liquid to form an intermediate concentrated dairy liquid; sterilizing the intermediate concentrated dairy liquid at a temperature and for a time sufficient to obtain the stable concentrated dairy liquid having a F 0 of at least 5; and the stable concentrated dairy liquid has a total solids from 25 to 30 percent, 9 to 13 percent total protein of which is at least 90 percent casein protein and less than 10 percent whey protein, and less than 1 percent lactose; and wherein the intermediate concentrated dairy liquid is resistant to gelation during sterilization, and wherein the stable concentrated dairy liquid is resistant to gelation for at least 9 months of storage under ambient conditions. providing a starting dairy liquid containing lactose and dairy protein with casein protein and whey protein; concentrating the casein protein and depleting the whey protein and lactose from the starting dairy liquid to form a whey and lactose depleted concentrated dairy liquid with a ratio of the casein protein to the whey protein of at least 90:10 and less than 1 percent lactose; maintaining the starting dairy liquid prior to and during the concentrating at or below a temperature so that no cross-linking occurs between the casein protein and the whey protein; adding a stabilizer and a mouthfeel enhancer to the whey and lactose depleted concentrated dairy liquid to form an intermediate concentrated dairy liquid; sterilizing the intermediate concentrated dairy liquid at a temperature and for a time sufficient to obtain the stable concentrated dairy liquid having a F 0 of at least 5; and the stable concentrated dairy liquid has a total solids from 25 to 30 percent, 9 to 13 percent total protein of which is at least 90 percent casein protein and less than 10 percent whey protein, and less than 1 percent lactose; and wherein the intermediate concentrated dairy liquid is resistant to gelation during sterilization, and wherein the stable concentrated dairy liquid is resistant to gelation for at least 9 months of storage under ambient conditions.
Method for producing an ultrasonic sensor for a motor vehicle by providing a sensor housing, a membrane for emitting and/or receiving ultrasonic signals, and a decoupling element, which is arranged between the sensor housing and the membrane, wherein the decoupling element is injection-moulded onto an inner surface of the sensor housing and the membrane is subsequently inserted into the sensor housing, characterized in that the sensor housing is formed by two housing shells (3, 4) that are separate from one another and the decoupling element is formed by two separate parts (6a, 6b), in that a part (6a, 6b) of the decoupling element is respectively injection-moulded onto the respective inner surfaces of the two housing shells (3, 4).
A child conveyance device comprising: an impact energy absorbing apparatus disposed on a portion of the child conveyance device, the impact energy absorbing apparatus including: an inner support configured to be positioned against the portion of the child conveyance device, the inner support having a receptacle formed therein; an outer cover configured to releasably secure the inner support; and an insert received within the receptacle of the inner support, the insert being held in place by the outer cover when securing the outer cover, the insert having a wall with a closed end and an open end, the insert sized to fit within the receptacle of the inner support with the closed end first entering the receptacle. an inner support configured to be positioned against the portion of the child conveyance device, the inner support having a receptacle formed therein; an outer cover configured to releasably secure the inner support; and an insert received within the receptacle of the inner support, the insert being held in place by the outer cover when securing the outer cover, the insert having a wall with a closed end and an open end, the insert sized to fit within the receptacle of the inner support with the closed end first entering the receptacle.
A synthetic antigenic peptide or an antigenic peptide isolated from natural sources, wherein said antigenic peptide is capable of activating T lymphocytes, wherein the antigenic peptide comprises the amino acid sequence SLVLNLLEL (SEQ ID NO:3), for use in treating multiple myeloma.
A tracking system for tracking the position and orientation of an object in an environment, the tracking system including: a) a tracking base positioned in the environment; b) a tracking target mountable to the object, wherein in use the tracking base is linked to the tracking target by: i) a bidirectional light beam transmitted therebetween; and, ii) a unidirectional light beam transmitted therebetween, said unidirectional light beam parallel to the bidirectional light beam; and, c) at least one controller configured to determine a roll angle of the tracking target relative to the tracking base, the roll angle determined at least in part by signals received from a sensor housed in at least one of the tracking base and the tracking target that detects the unidirectional light beam; said tracking system being characterised in that, the unidirectional light beam transits an optical mount mounted on at least one of the tracking base and tracking target for controlled rotation about an axis of rotation that is coaxial with the bidirectional light beam, the controller is configured to control the rotation of the optical mount in order to maintain linkage of the unidirectional light beam transmitted between the tracking base and the tracking target, and the angle of the controlled rotation is determined by the controller and roll angle data derived therefrom. a) a tracking base positioned in the environment; b) a tracking target mountable to the object, wherein in use the tracking base is linked to the tracking target by: i) a bidirectional light beam transmitted therebetween; and, ii) a unidirectional light beam transmitted therebetween, said unidirectional light beam parallel to the bidirectional light beam; and, i) a bidirectional light beam transmitted therebetween; and, ii) a unidirectional light beam transmitted therebetween, said unidirectional light beam parallel to the bidirectional light beam; and, c) at least one controller configured to determine a roll angle of the tracking target relative to the tracking base, the roll angle determined at least in part by signals received from a sensor housed in at least one of the tracking base and the tracking target that detects the unidirectional light beam; said tracking system being characterised in that, the unidirectional light beam transits an optical mount mounted on at least one of the tracking base and tracking target for controlled rotation about an axis of rotation that is coaxial with the bidirectional light beam, the controller is configured to control the rotation of the optical mount in order to maintain linkage of the unidirectional light beam transmitted between the tracking base and the tracking target, and the angle of the controlled rotation is determined by the controller and roll angle data derived therefrom.
Laminated automotive glazing of curved shape, said glazing resulting from the assembly of a first glass sheet that is bent prior to this assembly, a thermoplastic interlayer sheet and a second glass sheet of thickness that is no larger than one third of the thickness of the first sheet, the second glass sheet having no curvature, or a curvature that is substantially less than the curvature of the first sheet before its assembly with the latter and the thermoplastic interlayer sheet, wherein the ratio of the thicknesses is at least 3/1 and wherein, in the assembly that is carried out, the second glass sheet has a surface stress that is no higher than 50 MPa, and preferably no higher than 30 MPa.
A projection apparatus, comprising: a casing, having a plurality of air inlets and an air outlet; a light source module, disposed in the casing, and configured to provide an illumination beam, wherein the light source module comprises a plurality of light sources; an optical engine module, disposed in the casing, and located on a transmission path of the illumination beam, and configured to convert the illumination beam into an image beam; a heat dissipation module, disposed in the casing, and connected to the plurality of light sources, wherein the heat dissipation module comprises a plurality of heat sinks, and the plurality of heat sinks are located between the optical engine module and the plurality of air inlets, respectively; and a projection lens, disposed in the casing, connected to the optical engine module, and configured to project the image beam out of the casing, wherein the casing comprises a first sidewall and a second sidewall opposite to each other, and a third sidewall and a fourth sidewall opposite to each other and connected to the first sidewall and the second sidewall, characterized in that the air outlet is disposed on the fourth sidewall, and the third sidewall is not configured with an air inlet or air outlet. a casing, having a plurality of air inlets and an air outlet; a light source module, disposed in the casing, and configured to provide an illumination beam, wherein the light source module comprises a plurality of light sources; an optical engine module, disposed in the casing, and located on a transmission path of the illumination beam, and configured to convert the illumination beam into an image beam; a heat dissipation module, disposed in the casing, and connected to the plurality of light sources, wherein the heat dissipation module comprises a plurality of heat sinks, and the plurality of heat sinks are located between the optical engine module and the plurality of air inlets, respectively; and a projection lens, disposed in the casing, connected to the optical engine module, and configured to project the image beam out of the casing, wherein the casing comprises a first sidewall and a second sidewall opposite to each other, and a third sidewall and a fourth sidewall opposite to each other and connected to the first sidewall and the second sidewall, characterized in that the air outlet is disposed on the fourth sidewall, and the third sidewall is not configured with an air inlet or air outlet.
A commercial vehicle structure, specifically curtain-sided structure, having a load bed and stanchions connected to the load bed, wherein multiple retaining elements are arranged between two adjacent stanchions, connect the latter and each comprise a strap-like, flexible reinforcement element, which can be placed under tensile loading and has two fastening ends, wherein the fastening ends are connected to the adjacent stanchions in a tension-resistant manner, and the respective reinforcement element is tensioned between the stanchions, wherein the stanchions have fastening means for transmitting a tensile force from the respective reinforcement element to the stanchions, and the fastening means are fastened to the stanchions in a height-adjustable manner, wherein the respective reinforcement element has a tensioning device for applying a tensioning force between the two stanchions, wherein the two fastening ends of the respective reinforcement element are loops which are hooked into the fastening means or the stanchions.
Lock comprising a lockable knob, structured in a closure tongue non-rotatably mounted on the shaft of a cylinder that rotates in a casing when a knob joined to it does so and characterized in that: a) the knob is mounted on the cylinder and casing with the possibility of being moved linearly, guided between two end positions of operation and locking. b) the casing and the knob have at least two geometrically arranged linear guides, that, in the linear movement of the knob, are engaged with or are released from each other. c) the cylinder and the knob each have radial openings, that are coaxial -to lock between them the knob and cylinder in locking position - or axially offset -to allow the operation of the lock - d) the cylinder and the casing each have geometrically arranged cams, that limit the rotational movement of the cylinder on the casing between the opening and closing positions of the tongue. a) the knob is mounted on the cylinder and casing with the possibility of being moved linearly, guided between two end positions of operation and locking. b) the casing and the knob have at least two geometrically arranged linear guides, that, in the linear movement of the knob, are engaged with or are released from each other. c) the cylinder and the knob each have radial openings, that are coaxial -to lock between them the knob and cylinder in locking position - or axially offset -to allow the operation of the lock - d) the cylinder and the casing each have geometrically arranged cams, that limit the rotational movement of the cylinder on the casing between the opening and closing positions of the tongue.