A method for transmitting a single channel of video and multiple channels of audio, the method comprises: allocating a different fixed initial synchronization source, SSRC, value for each channel of audio by a device end; establishing a real time streaming protocol, RTSP, interaction mode between a client end and the device end; wherein in a DESCRIBE phase during the RTSP interaction mode, for each channel of audio, the device end randomly generating a corresponding modified SSRC value to be written into a realtime transport protocol, RTP, packet, and then the device end carrying the corresponding modified SSRC value of each channel of audio in a session description protocol, SDP, information to send it to the client end; the client end requesting, from the device end, the single channel of video and the multiple channels of audio; wherein this channel of video corresponds to a monitoring area, and the multiple channels of audio respectively correspond to sound captured by multiple different microphones placed in multiple different functional zones which are obtained by dividing the monitoring area; the device end capturing the single channel of video and the multiple channels of audio, generating an RTP packet of the single channel of video and sending the RTP packet to the client end, generating an RTP packet of each channel of audio containing an initial SSRC value, and modifying the initial SSRC value in the RTP packet of each channel of audio to the corresponding modified SSRC value, then sending the RTP packet of each channel of audio containing the modified SSRC value to the client end, wherein, each RTP packet contains a PT value distinguishing a video from an audio; the client end receiving RTP packets of the single channel of video and of the multiple channels of audio, distinguishing the video from the audio according to the PT values in the RTP packets, distinguishing individual channels of audio according to the modified SSRC values in the RTP packets of the multiple channels of audio, and playing the video and/or the audio of a corresponding channel according to user's demands. allocating a different fixed initial synchronization source, SSRC, value for each channel of audio by a device end; establishing a real time streaming protocol, RTSP, interaction mode between a client end and the device end; wherein in a DESCRIBE phase during the RTSP interaction mode, for each channel of audio, the device end randomly generating a corresponding modified SSRC value to be written into a realtime transport protocol, RTP, packet, and then the device end carrying the corresponding modified SSRC value of each channel of audio in a session description protocol, SDP, information to send it to the client end; the client end requesting, from the device end, the single channel of video and the multiple channels of audio; wherein this channel of video corresponds to a monitoring area, and the multiple channels of audio respectively correspond to sound captured by multiple different microphones placed in multiple different functional zones which are obtained by dividing the monitoring area; the device end capturing the single channel of video and the multiple channels of audio, generating an RTP packet of the single channel of video and sending the RTP packet to the client end, generating an RTP packet of each channel of audio containing an initial SSRC value, and modifying the initial SSRC value in the RTP packet of each channel of audio to the corresponding modified SSRC value, then sending the RTP packet of each channel of audio containing the modified SSRC value to the client end, wherein, each RTP packet contains a PT value distinguishing a video from an audio; the client end receiving RTP packets of the single channel of video and of the multiple channels of audio, distinguishing the video from the audio according to the PT values in the RTP packets, distinguishing individual channels of audio according to the modified SSRC values in the RTP packets of the multiple channels of audio, and playing the video and/or the audio of a corresponding channel according to user's demands.