A fluoro-substituted cyclic amine compound as shown in general formula I, a racemate, a R-isomer, a S-isomer and a pharmaceutically acceptable salt thereof or a mixture thereof: wherein m is an interger of 0-3, wherein m preferably is 0, 1 or 2; n is an interger of 0-3, wherein n preferably is 0, 1 or 2; X is (CH 2) p, CO or SO 2, wherein p is an interger of 0-3; R 1 is a substituted or unsubstituted C 3 -C 10 cycloalkyl, a substituted or unsubstituted C 3 -C 10 cycloalkenyl, a substituted or unsubstituted 3-12 membered heterocyclic group, a substituted or unsubstituted C 6 -C 12 aryl; the substituent(s) of R 1 is 1, 2, 3, 4 or 5 same or different substituents independently selected from the group consisting of a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 alkoxycarbonyl, a halogen substituted C 1 -C 6 alkoxy, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a C 3 -C 8 cycloalkyl, a cyano, a nitro, an amino, a hydroxyl, a hydroxymethyl, a carboxyl, a mercapto, a sulfonyl, a C 6 -C 10 aryl and a 3-12 membered heterocyclic radical; or two adjacent substituents of the C 6 -C 12 aryl and carbon atom(s) of adjacent aromatic ring together form a C 3 -C 7 cycloalkyl, a C 3 -C 7 cycloalkenyl or a 3-7 membered heterocyclic radical; and each heterocyclic radical independently contains 1-4 heteroatoms selected from O, S or N; each of R 2 and R 3 is independently selected from a group consisting of a hydrogen, a carboxyl, a C 1 -C 4 alkoxycarbonyl and a C 1 -C 4 alkyl; or R 2 and R 3 together form a C 1 -C 4 alkylidene; R 4 is 1-4 same or different substituents selected from a group consisting of a hydrogen, a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a halogen substituted C 1 -C 6 alkoxy, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a cyano, a nitro, an amino, a hydroxyl, a hydroxymethyl, a carboxyl, a mercapto, a sulfonyl, -O[(CH 2) q O] r R 5, a phenyl and a 3-12 membered heterocyclic radical; wherein the heterocyclic radical contains 1-3 heteroatoms selected from O, S or N; R 5 is selected from a group consisting of a hydrogen, a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl and a hydroxymethyl; q is 1, 2, 3 or 4; and r is 1, 2, 3 or 4; said halogen is F, Cl, Br or I. m is an interger of 0-3, wherein m preferably is 0, 1 or 2; n is an interger of 0-3, wherein n preferably is 0, 1 or 2; X is (CH 2) p, CO or SO 2, wherein p is an interger of 0-3; R 1 is a substituted or unsubstituted C 3 -C 10 cycloalkyl, a substituted or unsubstituted C 3 -C 10 cycloalkenyl, a substituted or unsubstituted 3-12 membered heterocyclic group, a substituted or unsubstituted C 6 -C 12 aryl; the substituent(s) of R 1 is 1, 2, 3, 4 or 5 same or different substituents independently selected from the group consisting of a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a C 1 -C 6 alkoxycarbonyl, a halogen substituted C 1 -C 6 alkoxy, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a C 3 -C 8 cycloalkyl, a cyano, a nitro, an amino, a hydroxyl, a hydroxymethyl, a carboxyl, a mercapto, a sulfonyl, a C 6 -C 10 aryl and a 3-12 membered heterocyclic radical; or two adjacent substituents of the C 6 -C 12 aryl and carbon atom(s) of adjacent aromatic ring together form a C 3 -C 7 cycloalkyl, a C 3 -C 7 cycloalkenyl or a 3-7 membered heterocyclic radical; and each heterocyclic radical independently contains 1-4 heteroatoms selected from O, S or N; each of R 2 and R 3 is independently selected from a group consisting of a hydrogen, a carboxyl, a C 1 -C 4 alkoxycarbonyl and a C 1 -C 4 alkyl; or R 2 and R 3 together form a C 1 -C 4 alkylidene; R 4 is 1-4 same or different substituents selected from a group consisting of a hydrogen, a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 1 -C 6 alkoxy, a halogen substituted C 1 -C 6 alkoxy, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl, a cyano, a nitro, an amino, a hydroxyl, a hydroxymethyl, a carboxyl, a mercapto, a sulfonyl, -O[(CH 2) q O] r R 5, a phenyl and a 3-12 membered heterocyclic radical; wherein the heterocyclic radical contains 1-3 heteroatoms selected from O, S or N; R 5 is selected from a group consisting of a hydrogen, a halogen, a C 1 -C 6 alkyl, a halogen substituted C 1 -C 6 alkyl, a C 2 -C 6 alkenyl, a C 2 -C 6 alkynyl and a hydroxymethyl; q is 1, 2, 3 or 4; and r is 1, 2, 3 or 4; said halogen is F, Cl, Br or I.