A compound according to Formula: or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, wherein: is, or; Z is S, S 2 or S NR 4, R 1 is OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 2 is H, (C 1 -C 8)alkyl or halogen; R 3 groups each independently are H, halogen, CN, OR 5, (C 1 -C 8)alkyl, (C 2 -C 8)alkenyl, (C 2 -C 8)alkynyl, NHR 5, NR 5 R 5, [(C 1 -C 8)alkylene]NHR 5, [(C 1 -C 8)alkylene]NR 5 R 5, N(C 1 -C 8)alkyl[(C 1 -C 8)alkylene]NHR 5, N(C 1 -C 8)alkyl[(C 1 -C 8)alkylene]NR 5 R 5, C NHR 5, C NR 5 R 5, SO 2 NHR 5, SO 2 NR 5 R 5, S R 5, SO 2 R 5, NR 5 C R 5, NR 5 SO 2 R 5, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 4 is H, CN, CO 2 (C 1 -C 8)alkyl, CO 2 cycloalkyl, CO 2 heterocyclyl, CO 2 aryl, CO 2 heteroaryl, CO 2 [(C 1 -C 8)alkylene]cycloalkyl, CO 2 [(C 1 -C 8)alkylene]heterocyclyl, CO 2 [(C 1 -C 8)alkylene]aryl or CO 2 [(C 1 -C 8)alkylene]heteroaryl; R 5 is H, (C 1 -C 8)alkyl, (C 1 -C 8)haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8)alkylene]cycloalkyl, [(C 1 -C 8)alkylene]heterocyclyl, [(C 1 -C 8)alkylene]aryl or [(C 1 -C 8)alkylene]heteroaryl, or R 5 and R 5 taken together with the nitrogen atom to which they are attached form a heterocyclyl; Ar is wherein R 6 is H, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8)alkylene]cycloalkyl or [(C 1 -C 8)alkylene]heterocyclyl; and wherein any alkyl, alkenyl, alkynyl, haloalkyl, alkylene, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1, 2 or 3 groups selected from OH, CN, NH 2, NO 2, halogen, cycloalkyl, -(C 1 -C 3 alkylene)NH 2 and -(C 1 -C 3 alkylene)N(C 1 -C 3 alkyl) 2. Z is S, S 2 or S NR 4, R 1 is OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 2 is H, (C 1 -C 8)alkyl or halogen; R 3 groups each independently are H, halogen, CN, OR 5, (C 1 -C 8)alkyl, (C 2 -C 8)alkenyl, (C 2 -C 8)alkynyl, NHR 5, NR 5 R 5, [(C 1 -C 8)alkylene]NHR 5, [(C 1 -C 8)alkylene]NR 5 R 5, N(C 1 -C 8)alkyl[(C 1 -C 8)alkylene]NHR 5, N(C 1 -C 8)alkyl[(C 1 -C 8)alkylene]NR 5 R 5, C NHR 5, C NR 5 R 5, SO 2 NHR 5, SO 2 NR 5 R 5, S R 5, SO 2 R 5, NR 5 C R 5, NR 5 SO 2 R 5, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 4 is H, CN, CO 2 (C 1 -C 8)alkyl, CO 2 cycloalkyl, CO 2 heterocyclyl, CO 2 aryl, CO 2 heteroaryl, CO 2 [(C 1 -C 8)alkylene]cycloalkyl, CO 2 [(C 1 -C 8)alkylene]heterocyclyl, CO 2 [(C 1 -C 8)alkylene]aryl or CO 2 [(C 1 -C 8)alkylene]heteroaryl; R 5 is H, (C 1 -C 8)alkyl, (C 1 -C 8)haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8)alkylene]cycloalkyl, [(C 1 -C 8)alkylene]heterocyclyl, [(C 1 -C 8)alkylene]aryl or [(C 1 -C 8)alkylene]heteroaryl, or R 5 and R 5 taken together with the nitrogen atom to which they are attached form a heterocyclyl; Ar is wherein R 6 is H, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8)alkylene]cycloalkyl or [(C 1 -C 8)alkylene]heterocyclyl; and wherein any alkyl, alkenyl, alkynyl, haloalkyl, alkylene, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1, 2 or 3 groups selected from OH, CN, NH 2, NO 2, halogen, cycloalkyl, -(C 1 -C 3 alkylene)NH 2 and -(C 1 -C 3 alkylene)N(C 1 -C 3 alkyl) 2.