mhurhangee/ep-ind-claims huggingface dataset:
A process for the enantioselective enzymatic reduction of a keto compound of general formula I wherein R represents a protective group for amino functions and X = -Cl, -CN, -OH, Br, F, to the hydroxy compound of general formula II (R,S-compound) wherein R and X have the same meaning as in formula I, with the keto compound being reduced with an oxidoreductase in the presence of cofactor NADH or NADPH, characterized in that the oxidized cofactor NAD or NADP formed is regenerated continuously by oxidation of a secondary alcohol of general formula R X R Y CHOH, wherein R X, R Y independently represent a branched or unbranched C 1 -C 8 -alkyl group and C total ≥ 3, and the TTN (total turn over number = mol of reduced compound of formula I / mol of cofactor used) is ≥10 3.
A computer-implemented method comprising: receiving input associated with saving task session state information associated with a web application that is integrated on a client device, wherein the client device comprises a web application mode browser which is a pared down version of a full browser, with many of normal functionalities turned off, and which serves as a runtime engine that enforces boundaries associated with user interactions; accessing a task session data structure in a web application directory; and saving task session state information in the task session data structure. receiving input associated with saving task session state information associated with a web application that is integrated on a client device, wherein the client device comprises a web application mode browser which is a pared down version of a full browser, with many of normal functionalities turned off, and which serves as a runtime engine that enforces boundaries associated with user interactions; accessing a task session data structure in a web application directory; and saving task session state information in the task session data structure.
Double clutch having two wet-running single clutches (K1, K2) for a double clutch transmission in a drive train of a vehicle, a first one of the single clutches connecting the clutch housing to a first transmission input shaft in a switchable manner, and a second one of the single clutches connecting the clutch housing to a second transmission input shaft in a switchable manner, each of the single wet clutches which are configured as a multiple disc clutch having an outer multiple disc carrier (8, 9) for suspending outer discs on an outer positively locking region and an inner multiple disc carrier (6, 7) for suspending inner discs on an inner positively locking region, and the positively locking regions having in each case one spline system and serving to connect the multiple disc carriers to the associated multiple discs fixedly so as to rotate with them, it being possible for the outer discs and the inner discs to be brought into frictional engagement with one another in order to transmit a torque, characterized in that the outer positively locking regions of the outer multiple disc carriers (8, 9) are formed in a forming process without cutting, and a continuously closed, substantially cylindrical region is configured at the open end of one of the outer positively locking regions, a diameter of the said cylindrical region being smaller than the tip circle diameter (Dz) of the spline system of the other outer positively locking region.
A device for preparing at least one solution of calibrated volume from at least one first sample and at least one first reagent, including a microfluidic network comprising at least one first inlet for supplying a first sample, at least one second inlet for supplying a first reagent, at least one discharge outlet, at least one outlet for collecting the solution to be analysed, a first sampling zone of calibrated volume (Ve) to which the first and second inlets are directly connected, at least first and second preparation chambers which are connected to the first sampling zone, and disposed on either side of the sampling zone such that the fluid intended to circulate from one preparation chamber to the other circulates in the first sampling zone, the first preparation chamber being of variable volume between a minimum volume and the calibrated volume (Vc), the second preparation chamber being of variable volume, said device also including means for allowing or interrupting the circulation of the fluid at least at the first and second inlets and at the collection and discharge outlets.
A magnetic element capable of generating and erasing a skyrmion, comprising: a magnet shaped as a thin layer and including a structure surrounded by a nonmagnetic material; a current path at least partially enclosing an end region including an end portion of the magnet, the current path being provided on one surface of the magnet; and a skyrmion sensor configured to detect the generation and erasing of the skyrmion, wherein, with Wm being a width of the magnet and hm being a height of the magnet, a size of the magnet, with the skyrmion of a diameter λ being generated, is such that 2λ > Wm > λ/2 and 2λ > hm > λ/2, wherein the magnet exhibits at least a skyrmion crystal phase generating the skyrmion and a ferromagnetic phase, according to a magnetic field applied thereto, wherein the magnetic element is arranged to interface with a magnetic field generating unit facing the one surface of the magnet and configured to apply a first magnetic field to the magnet from a first direction; and a first power supply configured to generate a second magnetic field in said end region by applying a current to said provided current path. a magnet shaped as a thin layer and including a structure surrounded by a nonmagnetic material; a current path at least partially enclosing an end region including an end portion of the magnet, the current path being provided on one surface of the magnet; and a skyrmion sensor configured to detect the generation and erasing of the skyrmion, wherein, with Wm being a width of the magnet and hm being a height of the magnet, a size of the magnet, with the skyrmion of a diameter λ being generated, is such that 2λ > Wm > λ/2 and 2λ > hm > λ/2, wherein the magnet exhibits at least a skyrmion crystal phase generating the skyrmion and a ferromagnetic phase, according to a magnetic field applied thereto, wherein the magnetic element is arranged to interface with a magnetic field generating unit facing the one surface of the magnet and configured to apply a first magnetic field to the magnet from a first direction; and a first power supply configured to generate a second magnetic field in said end region by applying a current to said provided current path.
A bicycle crankset provided with two arms mounted on opposite sides of a support, characterized in that, inside one of the arms (2, 2'), near the support, there is a cylindrical socket for a bolt ended on one side with a pin coupled with a socket (4, 4') provided in a non-rotating sleeve, around which the arm (2,2') rotates to the right or left by any angle from 0° to 360°, and on the other side of the bolt, there is a flange in contact with the arm of the two-arm lever pivotally mounted on an axle, with a compression spring placed inside the cylindrical socket.
A directly compressible calcium dietary supplement composition, comprising, based on 100 parts by weight of the composition: from 20 to 80 parts by weight of an agglomerate, comprising 90 to 99 parts by weight tricalcium phosphate particles, each having an outer surface, and 10 to 1 parts by weight binder comprising a polyvinylpyrollidone, carageenan, or a guar gum, supported on at least a portion of the outer surface of at least a portion of the tricalcium phosphate particles, from 79 to 10 parts by weight of particles of one or more calcium containing materials other than the agglomerate comprising tricalcium phosphate particles that exhibit a particle size distribution wherein less than or equal to 15 percent by weight of the particles have a particle size of greater than 300 μm (40 mesh) and less than or equal to 5 percent by weight of the particles have a particle size of less than 50 μm (325 mesh), from 0.5 to 8 parts by weight of a disintegrant, and from 0.5 to 2 parts by weight of a lubricant. from 20 to 80 parts by weight of an agglomerate, comprising 90 to 99 parts by weight tricalcium phosphate particles, each having an outer surface, and 10 to 1 parts by weight binder comprising a polyvinylpyrollidone, carageenan, or a guar gum, supported on at least a portion of the outer surface of at least a portion of the tricalcium phosphate particles, from 79 to 10 parts by weight of particles of one or more calcium containing materials other than the agglomerate comprising tricalcium phosphate particles that exhibit a particle size distribution wherein less than or equal to 15 percent by weight of the particles have a particle size of greater than 300 μm (40 mesh) and less than or equal to 5 percent by weight of the particles have a particle size of less than 50 μm (325 mesh), from 0.5 to 8 parts by weight of a disintegrant, and from 0.5 to 2 parts by weight of a lubricant.
Vertical centre of mass movement measuring apparatus comprising an inertial sensing device, for producing outputs relating to rotation and acceleration in its local frame of reference and configured for fastening to the back of an animal, a memory and a processor, wherein the processor is programmed to provide a quaternion corresponding to the rotation of the inertial sensing device and a first acceleration, both based on an output of the sensing device, and the processor is programmed to combine the quaternion and the first acceleration and based on data which is the result of the combination to provide, when the device is fastened close to the centre of mass of the animal, an estimate of vertical displacement, or a derivative of vertical displacement, of the centre of mass in a global reference frame, and wherein the apparatus is configured to apply a mathematical function to the data from the combining of the first acceleration and quaternion, to remove noise/errors that contribute to drift, wherein the mathematical function is a Hanning window, and the processor is programmed to provide an acceleration in the vertical direction, and to measure the speed of the sensing device in the vertical direction of the global reference frame by integrating the acceleration in the vertical direction using Simpson's rule.
Joint prosthesis assembly, comprising a joint prosthesis body made of a first biocompatible non-resorbable material; an anchoring element (2-5; 6) made of a second biocompatible non-resorbable material; wherein the joint prosthesis body comprises and end portion having a bore, and wherein the anchoring element (2-5; 6) extends through the bore and is arranged to allow free rotation of the end portion of the joint prosthesis body with respect to the anchoring element (2-5; 6) when in situ, characterised in that the anchoring element (2-5; 6) comprises a plug, and a cable (5; 6) attached to the plug, made of a third biocompatible non-resorbable material, e.g. a stainless steel or a polymer cord.
A method for determining the fill level of at least one coin tube that can be filled with coins, comprising the steps of: - capturing at least one spatially resolved image of the upper side of the at least one coin tube using a spatially resolving optical sensor (20, 20'), arranged at a defined distance to the upper side of the at least one coin tube and above the at least one coin tube and directed onto the upper side of the at least one coin tube, - transmitting the at least one spatially resolved image to an evaluation unit, - evaluating the at least one spatially resolved image by the evaluation unit by means of image processing, wherein the diameter of the uppermost coin filled into the coin tube is detected in the spatially resolved image and wherein the fill level of the at least one coin tube is determined from the ratio between the inner or outer diameter of the at least one coin tube on the spatially resolved image and the detected diameter of the uppermost coin filled into the coin tube, wherein the inner diameter of the at least one coin tube is the diameter of the opening of the at least one coin tube, and wherein the outer diameter of the at least one coin tube is the diameter of the outer wall of the at least one coin tube. - capturing at least one spatially resolved image of the upper side of the at least one coin tube using a spatially resolving optical sensor (20, 20'), arranged at a defined distance to the upper side of the at least one coin tube and above the at least one coin tube and directed onto the upper side of the at least one coin tube, - transmitting the at least one spatially resolved image to an evaluation unit, - evaluating the at least one spatially resolved image by the evaluation unit by means of image processing, wherein the diameter of the uppermost coin filled into the coin tube is detected in the spatially resolved image and wherein the fill level of the at least one coin tube is determined from the ratio between the inner or outer diameter of the at least one coin tube on the spatially resolved image and the detected diameter of the uppermost coin filled into the coin tube, wherein the inner diameter of the at least one coin tube is the diameter of the opening of the at least one coin tube, and wherein the outer diameter of the at least one coin tube is the diameter of the outer wall of the at least one coin tube.
Method of producing a protein in a eukaryotic production cell line, comprising the steps of a) providing a bacterial artificial chromosome, b) recombining a heterologous promoter and a nucleic acid encoding said protein into said BAC to generate a BAC expression vector, c) randomly integrating said BAC expression vector into the chromosome of a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line, which comprises at least 5 integrated BAC copies in the host cell, to produce said protein, and e) isolating said protein. a) providing a bacterial artificial chromosome, b) recombining a heterologous promoter and a nucleic acid encoding said protein into said BAC to generate a BAC expression vector, c) randomly integrating said BAC expression vector into the chromosome of a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line, which comprises at least 5 integrated BAC copies in the host cell, to produce said protein, and e) isolating said protein.
A bladed rotor system for a turbomachine, comprising: a circumferential row of blades mounted on a rotor disc, each blade comprising an airfoil having an outer wall delimiting an airfoil interior, the airfoil interior comprising one or more internal cavities (22, 24, 26), the row of blades comprising a first set of blades and a second set of blades, wherein: the airfoils of both the first and second sets (H, L) of blades have identical outer shapes defined by an outer surface of the outer wall of the respective airfoils, and the airfoils of the first set of blades are distinguished from the airfoils of the second set of blades by a geometry and/or position of at least one internal cavity, which is unique to blades of a given set (H, L), said at least one cavity being a trailing edge cooling passage, whereby the natural frequency of a blade of the first set differs from the natural frequency of a blade of the second set by a predetermined amount, wherein blades of the first set and the second set are alternately arranged in a periodic fashion in said circumferential row, to provide a frequency mistuning to stabilize flutter of the blades. a circumferential row of blades mounted on a rotor disc, each blade comprising an airfoil having an outer wall delimiting an airfoil interior, the airfoil interior comprising one or more internal cavities (22, 24, 26), the row of blades comprising a first set of blades and a second set of blades, wherein: the airfoils of both the first and second sets (H, L) of blades have identical outer shapes defined by an outer surface of the outer wall of the respective airfoils, and the airfoils of the first set of blades are distinguished from the airfoils of the second set of blades by a geometry and/or position of at least one internal cavity, which is unique to blades of a given set (H, L), said at least one cavity being a trailing edge cooling passage, the airfoils of both the first and second sets (H, L) of blades have identical outer shapes defined by an outer surface of the outer wall of the respective airfoils, and the airfoils of the first set of blades are distinguished from the airfoils of the second set of blades by a geometry and/or position of at least one internal cavity, which is unique to blades of a given set (H, L), said at least one cavity being a trailing edge cooling passage, whereby the natural frequency of a blade of the first set differs from the natural frequency of a blade of the second set by a predetermined amount, wherein blades of the first set and the second set are alternately arranged in a periodic fashion in said circumferential row, to provide a frequency mistuning to stabilize flutter of the blades.
Use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the preparation of a medicament for preventing and/or treating inflammation after ischemia/reperfusion and/or organ injury after ischemia/reperfusion.
A compressor, comprising: a compression cylinder configured to have a cylinder that forms a compression space for compressing gas and a valve plate that has a plurality of discharge ports (233, 234, 235) for discharging the compressed gas provided along a predetermined direction in which a straight line passes through a plurality of centres of the plurality of discharge ports; and a plurality of discharge valves comprising: a plurality of valve heads (422, 432, 442) that are provided to cover the plurality of discharge ports (233, 234, 235), and a plurality of valve necks (423, 433, 443) that extend toward a point of intersection of a plurality of centre lines, the point of intersection being on a line perpendicular to the straight line, wherein at least one of the plurality of valve necks extends to a different length from the plurality of valve heads to the point of intersection and gradually narrows toward the point of intersection. a compression cylinder configured to have a cylinder that forms a compression space for compressing gas and a valve plate that has a plurality of discharge ports (233, 234, 235) for discharging the compressed gas provided along a predetermined direction in which a straight line passes through a plurality of centres of the plurality of discharge ports; and a plurality of discharge valves comprising: a plurality of valve heads (422, 432, 442) that are provided to cover the plurality of discharge ports (233, 234, 235), and a plurality of valve necks (423, 433, 443) that extend toward a point of intersection of a plurality of centre lines, the point of intersection being on a line perpendicular to the straight line, wherein at least one of the plurality of valve necks extends to a different length from the plurality of valve heads to the point of intersection and gradually narrows toward the point of intersection. a plurality of valve heads (422, 432, 442) that are provided to cover the plurality of discharge ports (233, 234, 235), and a plurality of valve necks (423, 433, 443) that extend toward a point of intersection of a plurality of centre lines, the point of intersection being on a line perpendicular to the straight line, wherein at least one of the plurality of valve necks extends to a different length from the plurality of valve heads to the point of intersection and gradually narrows toward the point of intersection.
An image sensor comprising an arrangement of pixels, the pixels including an acquisition circuit each, the acquisition circuit including: a sensor circuit configured to generate a sensor signal (VLOG) depending on a light signal illuminating a photosensor of the pixel; a storage circuit configured to store during a storage interval a stored signal (VSTORE) proportional to the sensor signal (VLOG); and a comparator circuit configured to generate after the storage interval a comparator signal (VCOMP) depending on the sensor signal (VLOG) and the stored signal (VSTORE), wherein the storage circuit includes at least one amplifier (A1, A2), and the comparator circuit includes the same at least one amplifier (A1, A2), and wherein the sensor signal (VLOG) is connected to an input of the at least one amplifier (A1, A2) and wherein another input of the at least one amplifier (A1, A2) is connected via a capacitor to ground, wherein the stored signal (VSTORE) is connected via the capacitor to ground, wherein the comparator signal (VCOMP) is generated after the storage interval additionally depending on a first offset signal (VREF_PLUS) during a first interval (φ1) and depending on a second offset signal (VREF_MINUS) during a second interval (φ2), wherein the first offset signal (VREF_PLUS) and the second offset signal (VREF_MINUS) are each offset in voltage from a reference signal (VREF). a sensor circuit configured to generate a sensor signal (VLOG) depending on a light signal illuminating a photosensor of the pixel; a storage circuit configured to store during a storage interval a stored signal (VSTORE) proportional to the sensor signal (VLOG); and a comparator circuit configured to generate after the storage interval a comparator signal (VCOMP) depending on the sensor signal (VLOG) and the stored signal (VSTORE), wherein the storage circuit includes at least one amplifier (A1, A2), and the comparator circuit includes the same at least one amplifier (A1, A2), and wherein the sensor signal (VLOG) is connected to an input of the at least one amplifier (A1, A2) and wherein another input of the at least one amplifier (A1, A2) is connected via a capacitor to ground, wherein the stored signal (VSTORE) is connected via the capacitor to ground, wherein the comparator signal (VCOMP) is generated after the storage interval additionally depending on a first offset signal (VREF_PLUS) during a first interval (φ1) and depending on a second offset signal (VREF_MINUS) during a second interval (φ2), wherein the first offset signal (VREF_PLUS) and the second offset signal (VREF_MINUS) are each offset in voltage from a reference signal (VREF).