mhurhangee/ep-ind-claims huggingface dataset:
A combination product comprising a Bcl-2 inhibitor and a chemotherapeutic agent, wherein the Bcl-2 inhibitor is selected from the group consisting of the following compounds or a pharmaceutically acceptable salt or solvate thereof: and wherein the chemotherapeutic agent is topotecan.
A method of detecting a target agent in a sample, comprising (a) contacting a sample with an antibody having binding specificity for a target agent and with a biosensor cell, and (b) assaying the biosensor cell for cellular activation, wherein the biosensor cell stably expresses a chimeric fusion protein, and wherein the chimeric fusion protein comprises an Fcγ receptor (FcγR) antibody-binding domain and a signaling domain, wherein the signaling domain is the immunoglobulin alpha (Igα) signaling domain set forth in SEQ ID NO:5, or a sequence variant thereof having at least 95% sequence identity over the entire length of SEQ ID NO:5, or wherein the signaling domain is the membrane Ig set forth in SEQ ID NO:6, or a sequence variant thereof having at least 95% sequence identity over the entire length of SEQ ID NO:6. (a) contacting a sample with an antibody having binding specificity for a target agent and with a biosensor cell, and (b) assaying the biosensor cell for cellular activation,
A skin treatment personal care device comprising: a handle having a gripping portion at one end and a head portion at an opposing end, the head portion includes a heat dissipating housing defining a pocket and having a top surface, the heat dissipating housing comprising a material having a thermal diffusivity greater than 10 W / m K; a light emitting diode positioned within the pocket adapted to provide one or more skin benefits; and a window forming a water tight seal covering the light emitting diode, characterized in that the skin treatment personal care device further comprises a shaving razor cartridge mounted to the heat dissipating housing. a handle having a gripping portion at one end and a head portion at an opposing end, the head portion includes a heat dissipating housing defining a pocket and having a top surface, the heat dissipating housing comprising a material having a thermal diffusivity greater than 10 W / m K; a light emitting diode positioned within the pocket adapted to provide one or more skin benefits; and a window forming a water tight seal covering the light emitting diode, characterized in that the skin treatment personal care device further comprises a shaving razor cartridge mounted to the heat dissipating housing.
A manufacturing method of a metallic magnetic powder, comprising the steps of: manufacturing a metallic magnetic powder constituted of metallic magnetic particles, containing a metallic magnetic phase with Fe, or Fe and Co as main components, rare earth elements (wherein yttrium is also treated as the rare earth element), one kind or more non-magnetic components such as Al and Si; removing the non-magnetic component from the metallic magnetic particles, by making a reducing agent act thereon, while making a complexing agent exist for forming a complex with the non-magnetic component in water; oxidizing the metallic magnetic particle with the non-magnetic component removed; substituting water adhered to the oxidized metallic magnetic particle, with an organic solvent; and coating the surface of the metallic magnetic particle with an organic matter different from the organic solvent, in a state of maintaining a wet condition of the metallic magnetic particle with the organic solvent adhered thereto. manufacturing a metallic magnetic powder constituted of metallic magnetic particles, containing a metallic magnetic phase with Fe, or Fe and Co as main components, rare earth elements (wherein yttrium is also treated as the rare earth element), one kind or more non-magnetic components such as Al and Si; removing the non-magnetic component from the metallic magnetic particles, by making a reducing agent act thereon, while making a complexing agent exist for forming a complex with the non-magnetic component in water; oxidizing the metallic magnetic particle with the non-magnetic component removed; substituting water adhered to the oxidized metallic magnetic particle, with an organic solvent; and coating the surface of the metallic magnetic particle with an organic matter different from the organic solvent, in a state of maintaining a wet condition of the metallic magnetic particle with the organic solvent adhered thereto.
A system for detecting foreign bodies on a window, comprising: a window; a light source coupled to a first edge of the window and configured to emit light toward the first edge causing a fraction of the light to be coupled to the window and to propagate across the window to a second edge of the window as electromagnetic radiation; a photodetector configured to measure a radiation power of outcoupled light, wherein the measured outcoupled light is a subset of the electromagnetic radiation that is outcoupled from the window, wherein the photodetector is coupled to the window such that the photodetector is located at or near a node of maximum power of the outcoupled light; a comparator configured to determine a difference between radiation power of the outcoupled light and a baseline radiation value, and output an output signal that initiates a control operation in response to determining that the difference satisfies a defined criterion, wherein the output signal is configured to at least one of increase a power of the light source, increase an aperture opening of the photodetector, or increase an integration time setting of the photodetector based on an amount of the difference between the radiation power and the baseline radiation value. a window; a light source coupled to a first edge of the window and configured to emit light toward the first edge causing a fraction of the light to be coupled to the window and to propagate across the window to a second edge of the window as electromagnetic radiation; a photodetector configured to measure a radiation power of outcoupled light, wherein the measured outcoupled light is a subset of the electromagnetic radiation that is outcoupled from the window, wherein the photodetector is coupled to the window such that the photodetector is located at or near a node of maximum power of the outcoupled light; a comparator configured to determine a difference between radiation power of the outcoupled light and a baseline radiation value, and output an output signal that initiates a control operation in response to determining that the difference satisfies a defined criterion, wherein the output signal is configured to at least one of increase a power of the light source, increase an aperture opening of the photodetector, or increase an integration time setting of the photodetector based on an amount of the difference between the radiation power and the baseline radiation value. determine a difference between radiation power of the outcoupled light and a baseline radiation value, and output an output signal that initiates a control operation in response to determining that the difference satisfies a defined criterion, wherein the output signal is configured to at least one of increase a power of the light source, increase an aperture opening of the photodetector, or increase an integration time setting of the photodetector based on an amount of the difference between the radiation power and the baseline radiation value.
Portable control apparatus for remote control of a plurality of household appliances, having a touch-sensitive display facility, having a control unit coupled to the display facility for actuating the display facility and for receiving control inputs carried out by a user on the touch-sensitive display facility, and having a communication facility for wireless communication with the household appliances, wherein the control unit is designed to actuate the display facility for displaying a graphical user interface for controlling the household appliances and, as a function of the control inputs carried out by the user by way of the user interface, to transmit control signals by way of the communication facility to the household appliances and to receive status signals from the household appliances and to output the same by way of the user interface, wherein the graphical user interface has a plurality of household appliance control pages which can be selected separately from one another for controlling in each case an assigned household appliance, and wherein the control unit is designed to display graphical household appliance objects (18, 19) in a household appliance selection menu of the user interface, which are linked in each case with one of the assigned household appliance control pages, and after receiving a control input, by way of which the user selects one of the household appliance objects (18, 19), to display the household appliance control page assigned to the selected household appliance, wherein the control unit is designed to provide a graphical appliance link object on the household appliance control page of at least one household appliance and/or on a page of a topic category which differs from the household appliance control pages, and after receiving a control input, by way of which the user selects the appliance link object, to change from the currently displayed page (38, 42) to a household appliance control page of the assigned household appliance defined by the selected appliance link object, characterised in that the control unit is designed to store the received control inputs in a storage device and to provide the at least one appliance link object and/or at least one link object for one page of a topic category which differs from the household appliance control pages as a function of a history of the control inputs.
A chelating agent according to the following formula: comprising a polymer backbone having a plurality of carbon atoms; and a plurality of reactive groups being coupled to separate carbon atoms of the backbone; wherein if n=0, 2+4 spacing results, and if n=1, 4+6 spacing results; R', R" and R''' are independently alkyl, alkenyl alkynyl or aryl; and R is H, Na +, K + or aliphatic organic group.
A stand (110, 210, 310) for supporting a printing device (102, 202, 302), the stand comprising: a first leg (111, 211, 311) and a second leg (112, 212, 312), the legs having upper ends for vertically supporting the printing device to horizontally span the legs above a supporting surface (101, 201, 301); a crossbar (114, 214, 314) fixed to the first leg at a first crossbar fixation point and fixed to the second leg at a second crossbar fixation point; and characterized in that the stand further comprises a linkage connected between the first and the second leg, the linkage comprising a first link, a second link and a third link connected in series, wherein: the first link is connected to the first leg in use at a first leg connection point; the second link is connected to the second leg in use at a second leg connection point; and the third link is connected to the crossbar to pivot about a third linkage pivot point and to the first and second links at first and second linkage connection points on opposite sides of the third linkage pivot point. a first leg (111, 211, 311) and a second leg (112, 212, 312), the legs having upper ends for vertically supporting the printing device to horizontally span the legs above a supporting surface (101, 201, 301); a crossbar (114, 214, 314) fixed to the first leg at a first crossbar fixation point and fixed to the second leg at a second crossbar fixation point; and characterized in that the stand further comprises a linkage connected between the first and the second leg, the linkage comprising a first link, a second link and a third link connected in series, wherein: the first link is connected to the first leg in use at a first leg connection point; the second link is connected to the second leg in use at a second leg connection point; and the third link is connected to the crossbar to pivot about a third linkage pivot point and to the first and second links at first and second linkage connection points on opposite sides of the third linkage pivot point. the first link is connected to the first leg in use at a first leg connection point; the second link is connected to the second leg in use at a second leg connection point; and the third link is connected to the crossbar to pivot about a third linkage pivot point and to the first and second links at first and second linkage connection points on opposite sides of the third linkage pivot point.
Method for operating a compressed-air system of a motor vehicle, in which during a charging phase ambient air is pumped by a compressor into a compressed-air section and is dried therein by an air dryer, and in which during a regeneration phase dry air is passed out of a compressed-air reservoir through the air dryer, as a result of which the latter is dried and at the same time the compressor is cooled, wherein the mass and/or the volume and/or the pressure and/or the temperature of the air pumped in, and/or the temperature of the ambient air and/or of the lubricating oil which lubricates the compressor and/or the rotation speed of the compressor and/or the air humidity of the ambient air is/are detected by sensor means and integrated, and a change is made from the charging phase to the regeneration phase as a function of the at least one integral, characterized in that the temperature of the compressor is estimated as a function of the integral of the pressure of the air pumped in and/or of the rotation speed of the compressor and/or of the humidity of the ambient air and/or of the temperature of the ambient air and/or of the lubricating oil.
Method for braking a vehicle, the brake system of which comprises a hydraulic vehicle brake and an electromechanical brake device with an electric brake motor, wherein in the event of a failure of the hydraulic vehicle brake the brake motor of the electromechanical brake device is activated in order to generate a braking force, and in addition a braking torque is generated in the drive train of the vehicle, characterized in that after the failure of the hydraulic vehicle brake the electromechanical brake device is firstly activated, and subsequently the drive train is adjusted in such a way that a braking torque is generated, wherein the braking torque of the drive train is maintained beyond the time at which a braking force is made available in the electromechanical brake device.
A cylinder lock comprising: a cylinder lock body; a cam; an actuator and a manual element for operating said cam; a clutch contained in said cylinder lock body that is selectively engaged with said cam and with either of said actuator and said manual element; and a plug disposed in said cylinder lock body, wherein turning said plug throws said cam; characterised by an overpowering device contained in said cylinder lock body operative to couple said plug with said cam and decouple said actuator and said manual element from operating said cam. a cylinder lock body; a cam; an actuator and a manual element for operating said cam; a clutch contained in said cylinder lock body that is selectively engaged with said cam and with either of said actuator and said manual element; and a plug disposed in said cylinder lock body, wherein turning said plug throws said cam;
A dental implant, comprising: a screw thread configured to be rotationally screwed into a jaw bone, a prosthesis support attached to an upper edge of the screw thread, and a penetrating element configured to linearly penetrate into a jaw bone, wherein said penetrating element is attached to a lower edge of said screw thread and comprises a sharp smooth tip, and wherein the screw thread is positioned between the penetrating element and the prosthesis support, wherein the implant is a drill-less implant for implantation directly in a jaw bone while compressing a jaw bone tissue that surrounds a site of the implantation, thus increasing forces that are exerted by the compressed jaw bone tissue towards the drill-less dental implant, and thus increasing a stability of the drill-less implant in the jaw bone, characterized in that the penetrating element comprises an elongated smooth cylinder positioned between the sharp smooth tip and the screw thread. a screw thread configured to be rotationally screwed into a jaw bone, a prosthesis support attached to an upper edge of the screw thread, and a penetrating element configured to linearly penetrate into a jaw bone, wherein said penetrating element is attached to a lower edge of said screw thread and comprises a sharp smooth tip, and wherein the screw thread is positioned between the penetrating element and the prosthesis support, wherein the implant is a drill-less implant for implantation directly in a jaw bone while compressing a jaw bone tissue that surrounds a site of the implantation, thus increasing forces that are exerted by the compressed jaw bone tissue towards the drill-less dental implant, and thus increasing a stability of the drill-less implant in the jaw bone, characterized in that the penetrating element comprises an elongated smooth cylinder positioned between the sharp smooth tip and the screw thread.
A method of manufacturing a capillary array comprising: providing a plurality of capillaries each being capable of being filled with a separation medium, each capillary including an inlet end portion that is capable of feeding a sample into the capillary and a light-illuminable portion that is capable of allowing the sample to be illuminated with light; and arranging the plurality of capillaries substantially parallel to each other along a substantially flat plane; characterized in that the method further comprises fixing a portion of the plurality of capillaries that are arranged substantially parallel to each other by hot-pressing a fixing member comprising a plastic film onto the plurality of capillaries; preparing a ribbon-shaped member formed by the plurality of substantially parallel capillaries; and arranging a detection cell comprising a side slot, at a location on the ribbon shaped member separate from the fixing member, such that the detection cell is arranged substantially parallel to the light-illuminable portions of the plurality of capillaries and the side slot is aligned perpendicular to the light illuminable portion and parallel to the flat plane; wherein the fixing member is spaced apart from the detection cell, and the capillaries are arranged equally spaced and parallel from the fixing member to the detection cell, and inside the detection cell. providing a plurality of capillaries each being capable of being filled with a separation medium, each capillary including an inlet end portion that is capable of feeding a sample into the capillary and a light-illuminable portion that is capable of allowing the sample to be illuminated with light; and arranging the plurality of capillaries substantially parallel to each other along a substantially flat plane; characterized in that the method further comprises fixing a portion of the plurality of capillaries that are arranged substantially parallel to each other by hot-pressing a fixing member comprising a plastic film onto the plurality of capillaries; preparing a ribbon-shaped member formed by the plurality of substantially parallel capillaries; and arranging a detection cell comprising a side slot, at a location on the ribbon shaped member separate from the fixing member, such that the detection cell is arranged substantially parallel to the light-illuminable portions of the plurality of capillaries and the side slot is aligned perpendicular to the light illuminable portion and parallel to the flat plane; fixing a portion of the plurality of capillaries that are arranged substantially parallel to each other by hot-pressing a fixing member comprising a plastic film onto the plurality of capillaries; preparing a ribbon-shaped member formed by the plurality of substantially parallel capillaries; and arranging a detection cell comprising a side slot, at a location on the ribbon shaped member separate from the fixing member, such that the detection cell is arranged substantially parallel to the light-illuminable portions of the plurality of capillaries and the side slot is aligned perpendicular to the light illuminable portion and parallel to the flat plane;
Arrangement for sealing a master cylinder on the piston rod side, in particular of a hydraulically actuated clutch or brake system, in which arrangement the piston rod which is connected to the piston of the master cylinder is protected against the penetration of dirt into the master cylinder by way of a gaiter-like seal in relation to the housing of the master cylinder, the seal comprising a first relatively elastic seal component and a second, relatively inelastic seal component, the first seal component being connected on one side in a sealed manner to the housing of the master cylinder and on the other side in a sealed manner to the second seal component, characterized in that the second seal component is arranged in a sealed manner on the piston rod and can be displaced on the latter.
A hydrogen storage device provided in a vehicle that uses hydrogen as a fuel, the hydrogen storage device comprising: a plurality of receptacles (22a, 22b); a plurality of hydrogen tanks (21a, 21b, 21c, 21d); and a flow channel through which hydrogen flows from the receptacles (22a, 22b) to the hydrogen tanks (21a, 21b, 21c, 21d), wherein: the flow channel has a confluence point configured such that the hydrogen merges into one on a downstream side of the receptacles (22a, 22b); the flow channel is configured to branch from the confluence point into the plurality of hydrogen tanks (21a, 21b, 21c, 21d); characterised in that in the flow channel, a length of a flow channel from every receptacle (22a, 22b) in the hydrogen storage device to the confluence point is shorter than a length of a flow channel from the confluence point to every hydrogen tank (21a, 21b, 21c, 21d) in the hydrogen storage device. a plurality of receptacles (22a, 22b); a plurality of hydrogen tanks (21a, 21b, 21c, 21d); and a flow channel through which hydrogen flows from the receptacles (22a, 22b) to the hydrogen tanks (21a, 21b, 21c, 21d), wherein: the flow channel has a confluence point configured such that the hydrogen merges into one on a downstream side of the receptacles (22a, 22b); the flow channel is configured to branch from the confluence point into the plurality of hydrogen tanks (21a, 21b, 21c, 21d); the flow channel has a confluence point configured such that the hydrogen merges into one on a downstream side of the receptacles (22a, 22b); the flow channel is configured to branch from the confluence point into the plurality of hydrogen tanks (21a, 21b, 21c, 21d);
A dongle for coupling an electrophysiologic catheter and a navigational system, including a patient interface unit, the dongle comprising: a body with a first electrical interface unit; and a support portion with a second electrical interface unit, the support portion having an outer flexible tubular member with shape memory, wherein the dongle body comprises electrical hardware configured to process electrical signals received from the catheter so that they can be understood and processed by the navigational system. a body with a first electrical interface unit; and a support portion with a second electrical interface unit, the support portion having an outer flexible tubular member with shape memory,