A method for generating a cell composition, the method comprising: (a) combining a first cell composition comprising naïve-like CD4+ T cells with a second cell composition comprising naïve-like CD8+ T cells to produce an input cell composition in which the ratio of naïve-like CD4+ T cells to naïve-like CD8+ T cells is between 0.8: 1 and 2.2:1, inclusive, wherein the ratio has been determined based on the number, number per volume, number per weight, or percentage of naïve-like CD4+ T cells in the first cell composition and the number, number per volume, number per weight, or percentage of naïve-like CD8+ T cells in the second cell composition, wherein the naïve-like CD4+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and wherein the naïve-like CD8+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and (b) contacting the input cell composition with an agent comprising a nucleic acid molecule encoding a recombinant receptor under conditions to introduce the nucleic acid molecule encoding the recombinant receptor into cells in the input cell composition. (a) combining a first cell composition comprising naïve-like CD4+ T cells with a second cell composition comprising naïve-like CD8+ T cells to produce an input cell composition in which the ratio of naïve-like CD4+ T cells to naïve-like CD8+ T cells is between 0.8: 1 and 2.2:1, inclusive, wherein the ratio has been determined based on the number, number per volume, number per weight, or percentage of naïve-like CD4+ T cells in the first cell composition and the number, number per volume, number per weight, or percentage of naïve-like CD8+ T cells in the second cell composition, wherein the naïve-like CD4+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and wherein the naïve-like CD8+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and wherein the ratio has been determined based on the number, number per volume, number per weight, or percentage of naïve-like CD4+ T cells in the first cell composition and the number, number per volume, number per weight, or percentage of naïve-like CD8+ T cells in the second cell composition, wherein the naïve-like CD4+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and wherein the naïve-like CD8+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and wherein the naïve-like CD8+ cells: (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and (i) are surface positive for CD45RA and CCR7; (ii) are surface positive CD27 and CCR7; or (iii) are surface positive for CCR7 and surface negative for CD62L; and (b) contacting the input cell composition with an agent comprising a nucleic acid molecule encoding a recombinant receptor under conditions to introduce the nucleic acid molecule encoding the recombinant receptor into cells in the input cell composition.