An intravascular pressure and flow monitoring system comprising: a display; an intravascular guide wire-based probe comprising one or more sensors disposed on a distal end of a guidewire, the one or more sensors comprising: an active resistor that is sensitive to temperature and pressure, and a passive resistor that is sensitive only to temperature; one or more memory devices; and a computing device in communication with the one or more memory devices, wherein the one or more memory devices comprise instructions executable by the computing device to cause the computing device to: process a first electrical signal associated with the active resistor and the passive resistor; process a second electrical signal associated with the passive resistor; determine intravascular pressure values based on the first electrical signal using a measurement circuit formed from the guide wire-based probe and an interface device; determine intravascular flow values using a transfer function based on the second electrical signal using the measurement circuit formed from the guide wire-based probe and the interface device; and generate, based on the intravascular pressure values and the intravascular flow values, a pressure versus flow curve that changes overtime, and cause the display to display said pressure versus flow curve that changes over time. a display; an intravascular guide wire-based probe comprising one or more sensors disposed on a distal end of a guidewire, the one or more sensors comprising: an active resistor that is sensitive to temperature and pressure, and a passive resistor that is sensitive only to temperature; an active resistor that is sensitive to temperature and pressure, and a passive resistor that is sensitive only to temperature; one or more memory devices; and a computing device in communication with the one or more memory devices, wherein the one or more memory devices comprise instructions executable by the computing device to cause the computing device to: process a first electrical signal associated with the active resistor and the passive resistor; process a second electrical signal associated with the passive resistor; determine intravascular pressure values based on the first electrical signal using a measurement circuit formed from the guide wire-based probe and an interface device; determine intravascular flow values using a transfer function based on the second electrical signal using the measurement circuit formed from the guide wire-based probe and the interface device; and generate, based on the intravascular pressure values and the intravascular flow values, a pressure versus flow curve that changes overtime, and cause the display to display said pressure versus flow curve that changes over time. process a first electrical signal associated with the active resistor and the passive resistor; process a second electrical signal associated with the passive resistor; determine intravascular pressure values based on the first electrical signal using a measurement circuit formed from the guide wire-based probe and an interface device; determine intravascular flow values using a transfer function based on the second electrical signal using the measurement circuit formed from the guide wire-based probe and the interface device; and generate, based on the intravascular pressure values and the intravascular flow values, a pressure versus flow curve that changes overtime, and cause the display to display said pressure versus flow curve that changes over time.