mhurhangee/ep-ind-claims huggingface dataset:
Four-point suspension arm for an axial suspension of a rigid axle, in particular of a commercial vehicle, the four-point suspension arm having four bearing receptacles, of which two bearing receptacles are articulatable on the vehicle axle and two bearing receptacles are articulatable on the vehicle frame, the four-point suspension arm comprising a torsionable suspension arm body (1, 2) which is essentially inscribed within the trapezium formed by the bearing receptacles and which is formed from a composite fibre arrangement, the composite fibre arrangement comprising at least one longitudinal fibre arrangement (10, 11) which is assigned to at least one bearing receptacle and which encloses the at least one bearing receptacle at least along half the circumference of the latter and runs along at least parts of the suspension arm body (1, 2), characterized by two longitudinal fibre arrangements (10, 11), in each case one longitudinal fibre arrangement (10, 11) being assigned to one of the two pairs of bearing receptacles arranged diagonally opposite one another.
A fluidic distribution system for cleaning surfaces of a vehicle, the distribution system comprising: - a main tank with a main volume and intended to store a cleaning fluid at a pressure called main pressure; - two secondary tanks, called, respectively, the first and second tank, each having a volume, called secondary volume, smaller than the main volume; - filling means configured to allow selective filling of both the first tank and the second tank with cleaning fluid from the main tank; characterized by further comprising - compression means configured to inject air selectively into one and the other of the first tank and the second tank, and so as to impose a working pressure, higher than the main pressure, on the cleaning fluid likely to be present in the considered secondary tank; - dispensing means configured to selectively dispense from either of the first and second tanks cleaning fluid and/or air for cleaning surfaces. - a main tank with a main volume and intended to store a cleaning fluid at a pressure called main pressure; - two secondary tanks, called, respectively, the first and second tank, each having a volume, called secondary volume, smaller than the main volume; - filling means configured to allow selective filling of both the first tank and the second tank with cleaning fluid from the main tank; characterized by further comprising - compression means configured to inject air selectively into one and the other of the first tank and the second tank, and so as to impose a working pressure, higher than the main pressure, on the cleaning fluid likely to be present in the considered secondary tank; - dispensing means configured to selectively dispense from either of the first and second tanks cleaning fluid and/or air for cleaning surfaces.
Heat pump system comprising a heat medium circuit (210,220,230,240,250,310,320,410,420,430,440,450,460) in turn comprising at least three heat exchanging means (314,315,316,422,433,452) arranged to transfer thermal energy between the heat medium and a respective heat source or sink selected from outdoor air, a water body, the ground, indoor air, pool water, tap water or a topmost ground layer, a valve means (311,312,313,421,431,451) arranged to selectively direct the heat medium to at least two of said heat exchanging means, and a control means arranged to control said valve means, wherein the heat pump system comprises respective temperature sensors (314a,314b;315a,315b;316a,316b;423,424,425;432,434,435) both upstream and down-stream of at least one of said heat exchanging means, in that the control means is arranged to, based upon temperature measurement values comprising at least one value read from said sensors, determine to which heat exchanging means the heat medium is to be directed, characterised in that when heat medium is not directed to a certain heat exchanging means the control means is arranged to read, repeatedly over time, a measured temperature value upstream and downstream of the certain heat exchanging means, and to set off an alert in case a difference between the read temperatures increases by more than a predetermined value between a reference reading, measured previously but after the disconnection of the delivery of heat medium to the heat exchanger in question, and a later reading, measured after the reference reading while the heat exchanger still does not receive any heat medium.
A pharmaceutical composition comprising a therapeutically effective amount of anti-GPC3 chimeric antigen receptor immunoresponsive cells for use in the treatment of a solid tumor in a subject, wherein the treatment comprises administering to the subject the pharmaceutical composition after or concurrent with subjecting the subject to a lymphocyte reduction treatment, wherein the lymphocyte reduction treatment comprises administering cyclophosphamide and fludarabine to the subject and wherein the anti-GPC3 CAR immunoresponsive cells are T cells (anti-GPC3 CAR T cells).
A composition for use in the treatment of castration resistant prostate cancer or doubly resistant prostate cancer comprising a compound having the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein: each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is optionally substituted phenyl; or each R 1 is -OR, -SR, -N 2, or -C 3, and R is an optionally substituted 3- to 8-membered saturated or partially unsaturated carbocyclyl ring; or each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is an optionally substituted 5-membered heteroaryl having 1 heteroatom selected from oxygen, nitrogen, or sulfur; or each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is an optionally substituted 6-membered heteroaryl having 1-3 nitrogens; or each R 1 is optionally substituted C 1-6 aliphatic; or each R 1 is C 1 alkyl-C 3-7 cycloalkyl, C 1 alkyl-heteroaryl, or C 1 alkyl-aryl, wherein the aryl group is selected from phenyl or 8- to 10-membered bicyclic aryl, and the heteroaryl group selected from 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, or 7- to 10-membered saturated or partially unsaturated bicyclic heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur; or two R 1 groups on adjacent atoms are taken together with their intervening atoms to form an optionally substituted fused 5- to 7-membered ring having 0-3 heteroatoms selected from oxygen, nitrogen, or sulfur; R 2 is optionally substituted unsaturated C 2-6 aliphatic; and n is from 0-4. each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is optionally substituted phenyl; or each R 1 is -OR, -SR, -N 2, or -C 3, and R is an optionally substituted 3- to 8-membered saturated or partially unsaturated carbocyclyl ring; or each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is an optionally substituted 5-membered heteroaryl having 1 heteroatom selected from oxygen, nitrogen, or sulfur; or each R 1 is -OR, -SR, -N 2, -S R, -S 2 R, or -C 3, and R is an optionally substituted 6-membered heteroaryl having 1-3 nitrogens; or each R 1 is optionally substituted C 1-6 aliphatic; or each R 1 is C 1 alkyl-C 3-7 cycloalkyl, C 1 alkyl-heteroaryl, or C 1 alkyl-aryl, wherein the aryl group is selected from phenyl or 8- to 10-membered bicyclic aryl, and the heteroaryl group selected from 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, or 7- to 10-membered saturated or partially unsaturated bicyclic heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur; or two R 1 groups on adjacent atoms are taken together with their intervening atoms to form an optionally substituted fused 5- to 7-membered ring having 0-3 heteroatoms selected from oxygen, nitrogen, or sulfur; R 2 is optionally substituted unsaturated C 2-6 aliphatic; and n is from 0-4.
A torque tube (24, 300, 400,500) for use in a disk brake system, comprising: a backleg (45, 304, 404, 504) having a reaction plate and a foot (212, 314, 414, 514) including axially-extending foot features (218, 416, 516) defining foot slots (222, 438) therebetween; a barrel (25, 302, 402, 502) having a tubular structure (200, 306, 406, 506) and axially-extending barrel features (204, 410, 510) configured to be received by the foot slots (222, 438) such that circumferential faces of the axially-extending foot features (218, 416, 516) contact circumferential surfaces of the axially-extending barrel features (204, 410, 510) in response to the axially-extending barrel features (204, 410, 510) being received by the foot slots (222, 438), characterized by connectors (224, 318, 420, 520) configured to extend through a portion of the backleg and a portion of the barrel (25, 302, 402, 502) to resist movement of the backleg (45, 304, 404, 504) relative to the barre (25, 302, 402, 502); or characterized in that at least a portion of the foot (212, 314, 414, 514) is configured to be received by a foot socket (311, 415, 515) defined by an inner surface (209, 310, 434) of the tubular structure (200, 306, 406, 506) such that an outer surface (315, 422) of the portion of the foot (212, 314, 414, 514) contacts the inner surface (209, 310, 434) of the tubular structure (200, 306, 406, 506) in response to the portion of the foot (212, 314, 414, 514) being received by the foot socket (311, 415, 515). a backleg (45, 304, 404, 504) having a reaction plate and a foot (212, 314, 414, 514) including axially-extending foot features (218, 416, 516) defining foot slots (222, 438) therebetween; a barrel (25, 302, 402, 502) having a tubular structure (200, 306, 406, 506) and axially-extending barrel features (204, 410, 510) configured to be received by the foot slots (222, 438) such that circumferential faces of the axially-extending foot features (218, 416, 516) contact circumferential surfaces of the axially-extending barrel features (204, 410, 510) in response to the axially-extending barrel features (204, 410, 510) being received by the foot slots (222, 438), characterized by connectors (224, 318, 420, 520) configured to extend through a portion of the backleg and a portion of the barrel (25, 302, 402, 502) to resist movement of the backleg (45, 304, 404, 504) relative to the barre (25, 302, 402, 502); or characterized in that at least a portion of the foot (212, 314, 414, 514) is configured to be received by a foot socket (311, 415, 515) defined by an inner surface (209, 310, 434) of the tubular structure (200, 306, 406, 506) such that an outer surface (315, 422) of the portion of the foot (212, 314, 414, 514) contacts the inner surface (209, 310, 434) of the tubular structure (200, 306, 406, 506) in response to the portion of the foot (212, 314, 414, 514) being received by the foot socket (311, 415, 515).
Panel dividing system comprising a machine table, comprising a dividing line present in the machine table, and comprising a pressure beam device that is arranged in a region above the dividing line and has at least one first pressure beam which is held on a stationary support extending preferably in parallel with the dividing line and can be moved orthogonally with respect to a plane of the machine table by means of at least one drive, the drive and/or a guiding device of the pressure beam device being arranged in a region above the dividing line, and the first pressure beam, when viewed in the direction of the dividing line, having at least two segments that can be moved independently of one another, characterized in that the panel dividing system comprises two program feeders (24A, 24B), one of the program feeders being a lateral slide, the drive comprising a crank drive.
A method of increasing skin chroma, the method comprising improving skin hydration by applying a multiphase personal cleansing composition comprising a benefit agent to the skin, said method comprising providing a rinse-off personal cleansing composition comprising a hydrophobic benefit agent, and depositing 5 μg/cm 2 or more of the hydrophobic benefit agent on skin; wherein the composition is multi-phase and comprises a cleansing phase and a benefit phase comprising the hydrophobic benefit agent and a soy oligomer; and wherein the level of hydration is in accordance with one of the following: a Corneometer measurement of 0.3 Corneometer units or more above a water control after treatment of at least once a day for at least 4 consecutive days when measured at 24 hours after the last treatment in accordance with the Corneometer Testing Method; a dry skin grade of 0.4 units or more above a water control after treatment of at least once a day for at least 3 consecutive days when measured at 3 hours after the last treatment in accordance with the Dry Skin Grade Method; or a combination thereof.
Power plant system comprising a solid oxide fuel cell (1, SOFC) and a gas turbine, wherein the fuel cell and the gas turbine are set up such that compressed charge air (Lc) of a compressor of the gas turbine can be provided to the fuel cell and/or an exhaust gas of the fuel cell can be provided to a combustion chamber of the gas turbine, wherein the system is configured such that the solid oxide fuel cell can be operated in a load or cell mode, the system being characterized in that the solid oxide fuel cell can as well be operated in an electrolysis mode and in that the solid oxide fuel cell (SOFC) is set up such that an excess grid energy is used for executing an electrolysis in the electrolysis mode of the fuel cell and thereby to chemically reduce water (H 2 O) and/or carbon dioxide into hydrogen (H 2) and/or syngas.
A scaffolding material for culturing a stem cell, having a dispersion component γ d of surface free energy of 28.0 or more and less than 38.0, and a dipole component γ p of surface free energy of 1.0 or more and less than 10.0, wherein the scaffolding material comprising a synthetic resin, the synthetic resin contains at least any one of a polyvinyl acetal skeleton and a poly(meth)acrylic ester skeleton. a dispersion component γ d of surface free energy of 28.0 or more and less than 38.0, and a dipole component γ p of surface free energy of 1.0 or more and less than 10.0, wherein the scaffolding material comprising a synthetic resin, the synthetic resin contains at least any one of a polyvinyl acetal skeleton and a poly(meth)acrylic ester skeleton.
A device for treating a hot gas flow containing slag in a housing, with - an inlet, arranged on the top, for the hot gas flow, - an immersion pipe which is vertically arranged concentrically in the housing and into which the inlet issues, - a coolant bath into which the immersion pipe dips with a lower portion, and - at least one crude gas outlet port for cooled crude gas freed of slag, wherein the lower portion of the immersion pipe being designed as a radially widened gas distributor bell in the coolant bath, characterized in that - the gas distributor bell is formed by an essentially conical surface area with a downwardly widening cross section, and - the surface area has a multiplicity of gas passage ports, wherein the gas passage ports are distributed over the circumference of the gas distributor bell, and the dimensions of the gas passage ports increase with the depth of penetration of the coolant bath. - an inlet, arranged on the top, for the hot gas flow, - an immersion pipe which is vertically arranged concentrically in the housing and into which the inlet issues, - a coolant bath into which the immersion pipe dips with a lower portion, and - at least one crude gas outlet port for cooled crude gas freed of slag, - the gas distributor bell is formed by an essentially conical surface area with a downwardly widening cross section, and - the surface area has a multiplicity of gas passage ports, wherein the gas passage ports are distributed over the circumference of the gas distributor bell, and the dimensions of the gas passage ports increase with the depth of penetration of the coolant bath.
A polynucleotide encoding a modified oleosin including at least one artificially introduced cysteine, wherein the cysteine is introduced into at least one of: a) the N-terminal hydrophilic region of the oleosin, and b) the C-terminal hydrophilic region of the oleosin. a) the N-terminal hydrophilic region of the oleosin, and b) the C-terminal hydrophilic region of the oleosin.
A dental fixture for insertion into a human jawbone, comprising a bone-contacting surface, wherein at least 15 % of the bone-contacting surface is designed such that when a Gaussian 50 μm high-pass filter and a Gaussian 3 μm low-pass filter is applied to an original unfiltered set of measurement data which represents a topography of said surface and which is obtained at 50 times magnification by white light interferometry, the resulting filtered set of data presents a surface roughness at the micrometer-level having the roughness average parameter S a ≥ 1 μm and the two-dimensional mean slope parameter R sl ≥ tan 30°, wherein said surface roughness is superposed by a nanostructure which, when a Gaussian 2 μm high-pass filter is applied to said set of measurement data, has a roughness average parameter S a ≥ 0.1 μm.
A door opening/closing apparatus comprising: a door opening/closing handle providable in a door of a vehicle; a sensor (4a, 4b) provided in the door handle; a detection circuit configured to detect a change in electrostatic capacitance occurring in the vicinity of the sensor (4a, 4b) in response to approaching or contacting of a human body portion relative to the door handle and to output a locking or unlocking operation signal; a device (8, 52L) for executing locking/unlocking of the door based on the operation signal; and a transmission/reception antenna (10, 14) for effecting transmission/reception with a portable unit corresponding to the vehicle; characterized in that the door handle includes an insulating base body on which a smooth coating for smoothing the surface thereof is formed, on a vehicle outer side surface of the base body, there is attached a metal layer comprised of a group of island shaped metal particles that extend along the surface of the smooth coating and that are separated from each other, the metal layer is formed by vacuum deposition and the metal particles are comprised of a metal element or an alloy having a lower melting point than aluminum, the inter-particle gaps between the metal particles adjacent each other range from 5 to 200 nm, and the metal particles have a particle diameter ranging from 10 nm to 2 μm. a door opening/closing handle providable in a door of a vehicle; a sensor (4a, 4b) provided in the door handle; a detection circuit configured to detect a change in electrostatic capacitance occurring in the vicinity of the sensor (4a, 4b) in response to approaching or contacting of a human body portion relative to the door handle and to output a locking or unlocking operation signal; a device (8, 52L) for executing locking/unlocking of the door based on the operation signal; and a transmission/reception antenna (10, 14) for effecting transmission/reception with a portable unit corresponding to the vehicle; characterized in that the door handle includes an insulating base body on which a smooth coating for smoothing the surface thereof is formed, on a vehicle outer side surface of the base body, there is attached a metal layer comprised of a group of island shaped metal particles that extend along the surface of the smooth coating and that are separated from each other, the metal layer is formed by vacuum deposition and the metal particles are comprised of a metal element or an alloy having a lower melting point than aluminum, the inter-particle gaps between the metal particles adjacent each other range from 5 to 200 nm, and the metal particles have a particle diameter ranging from 10 nm to 2 μm.
A braking apparatus of a vehicle, comprising: a friction brake device that brakes the vehicle via friction in response to operation of a brake pedal; a regenerative brake device that performs regenerative braking using, as an electricity generator, an electric motor for running the vehicle; and a collision avoidance device that performs automatic braking of the vehicle by controlling operation of the friction brake device in accordance with obstacle detection information detected by an obstacle detection device, to avoid collision of the vehicle with an obstacle, wherein the collision avoidance device terminates activation of the regenerative braking before the automatic braking is started, if the regenerative braking is activated before the automatic braking is started, characterized in that: when the regenerative braking is to be terminated before the automatic braking is started, braking force generated by the regenerative brake device is gradually reduced and friction braking is gradually intensified correspondingly to the gradual reduction of the braking force. a friction brake device that brakes the vehicle via friction in response to operation of a brake pedal; a regenerative brake device that performs regenerative braking using, as an electricity generator, an electric motor for running the vehicle; and a collision avoidance device that performs automatic braking of the vehicle by controlling operation of the friction brake device in accordance with obstacle detection information detected by an obstacle detection device, to avoid collision of the vehicle with an obstacle, wherein the collision avoidance device terminates activation of the regenerative braking before the automatic braking is started, if the regenerative braking is activated before the automatic braking is started, characterized in that: when the regenerative braking is to be terminated before the automatic braking is started, braking force generated by the regenerative brake device is gradually reduced and friction braking is gradually intensified correspondingly to the gradual reduction of the braking force. when the regenerative braking is to be terminated before the automatic braking is started, braking force generated by the regenerative brake device is gradually reduced and friction braking is gradually intensified correspondingly to the gradual reduction of the braking force.
An inhaler comprising a housing containing a strip of blisters each blister being defined by a blister cavity containing a dose of medicament and a puncturable lid, the inhaler including means to sequentially move each blister into alignment with means for puncturing said puncturable lid of a blister to enable a user to inhale said dose through said puncturable lid and, a spiral wound element (60,150) in said housing to receive a used portion of said strip, said used portion being formed from blister cavities and punctured lids that have been aligned with said means for puncturing the lid of a blister, said spiral wound element (60,150) having an inner and outer surface, an outer end fixed to the housing and a winding that extends over 360 degrees, characterised in that the strip of blisters has a leading end and the spiral wound element (60,150) is resiliently deformable such that the leading end of a used portion of the strip formed from blisters which have been aligned with said means for opening a blister, enters the spiral wound element (60,150) between said inner and outer surface to cause the used portion of the strip, comprising the blister cavities and their punctured lids, to coil within it, said spiral wound element (60,150) gradually expanding as the length of the used portion of the strip coiled within it increases.