mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising (i) a protoxin fusion protein comprising a first cell-targeting moiety, a selectively modifiable activation domain, and a toxin domain; and (ii) a protoxin activator fusion protein comprising a second cell targeting moiety, a natively activatable domain, and a modification domain, wherein: said modification domain is a protease or phosphatase domain, said selectively modifiable activation domain is a substrate for said protease or phosphatase domain, and said natively activatable domain is a substrate for a protease, wherein the protease is a ubiquitously distributed protease or a target cell specific protease; said modification domain is inactive prior to activation of said natively activatable domain; and wherein said first cell-targeting moiety of the protoxin fusion protein and said second cell-targeting moiety of the active protoxin activator fusion protein, recognize and bind to a target cell and, when both fusion proteins are bound to said target cell, said modification domain activates said selectively modifiable activation domain resulting in toxin activity. (i) a protoxin fusion protein comprising a first cell-targeting moiety, a selectively modifiable activation domain, and a toxin domain; and (ii) a protoxin activator fusion protein comprising a second cell targeting moiety, a natively activatable domain, and a modification domain, said modification domain is a protease or phosphatase domain, said selectively modifiable activation domain is a substrate for said protease or phosphatase domain, and said natively activatable domain is a substrate for a protease, wherein the protease is a ubiquitously distributed protease or a target cell specific protease; said modification domain is inactive prior to activation of said natively activatable domain; and wherein said first cell-targeting moiety of the protoxin fusion protein and said second cell-targeting moiety of the active protoxin activator fusion protein, recognize and bind to a target cell and, when both fusion proteins are bound to said target cell, said modification domain activates said selectively modifiable activation domain resulting in toxin activity.
A computer-implemented method for determining a salient reactivity of at least one target sensory stimulus applied to a subject, the method comprising: - obtaining physiological signals from the subject during a stimulation with the target sensory stimulus and during a stimulation with a reference sensory stimulus, the physiological signals comprising a plurality of channels, wherein the physiological signals are electroencephalographic signals, - determining, at a plurality of time points of the physiological signals, topographic spectral power maps, wherein a topographic spectral power map comprises spectral powers of frequency bands of the plurality of channels, - clustering the topographic spectral power maps to obtain a plurality of macrostates, - identifying, among the plurality of macrostates, a default macrostate as the macrostate which shows a largest suppression during stimulation, wherein a suppression of a macrostate during a sensory stimulus is determined as a difference between the probability of occurrence of the macrostate during the sensory stimulus compared to the probability of occurrence of the macrostate in a period before the sensory stimulus, and - determining the salient reactivity based on a difference between the suppression of the default macrostate during the target sensory stimulus and a suppression of the default macrostate during the reference sensory stimulus. - obtaining physiological signals from the subject during a stimulation with the target sensory stimulus and during a stimulation with a reference sensory stimulus, the physiological signals comprising a plurality of channels, wherein the physiological signals are electroencephalographic signals, - determining, at a plurality of time points of the physiological signals, topographic spectral power maps, wherein a topographic spectral power map comprises spectral powers of frequency bands of the plurality of channels, - clustering the topographic spectral power maps to obtain a plurality of macrostates, - identifying, among the plurality of macrostates, a default macrostate as the macrostate which shows a largest suppression during stimulation, wherein a suppression of a macrostate during a sensory stimulus is determined as a difference between the probability of occurrence of the macrostate during the sensory stimulus compared to the probability of occurrence of the macrostate in a period before the sensory stimulus, and - determining the salient reactivity based on a difference between the suppression of the default macrostate during the target sensory stimulus and a suppression of the default macrostate during the reference sensory stimulus.
A system for microsurgery comprising: a first assembly and a second assembly, each including: a planar remote center of motion device configured to constrain motion of a surgical instrument attached to the planar remote center of motion device such that an axis of the surgical instrument passes through a remote center of motion while remaining in a planar region defined based on a rotational orientation of the planar remote center of motion device; and a rotational device attached to the planar remote center of motion device and configured such that an axis of rotation of the rotational device passes through the remote center of motion, wherein the rotational orientation of the planar remote center of motion device is defined about the axis of rotation; characterised in that the first assembly is configured to be positioned adjacent to the second assembly such that at least a portion of the planar remote center of motion device of the first assembly is offset from the axis of rotation of the rotational device of the first assembly. a first assembly and a second assembly, each including: a planar remote center of motion device configured to constrain motion of a surgical instrument attached to the planar remote center of motion device such that an axis of the surgical instrument passes through a remote center of motion while remaining in a planar region defined based on a rotational orientation of the planar remote center of motion device; and a rotational device attached to the planar remote center of motion device and configured such that an axis of rotation of the rotational device passes through the remote center of motion, wherein the rotational orientation of the planar remote center of motion device is defined about the axis of rotation; a planar remote center of motion device configured to constrain motion of a surgical instrument attached to the planar remote center of motion device such that an axis of the surgical instrument passes through a remote center of motion while remaining in a planar region defined based on a rotational orientation of the planar remote center of motion device; and a rotational device attached to the planar remote center of motion device and configured such that an axis of rotation of the rotational device passes through the remote center of motion, wherein the rotational orientation of the planar remote center of motion device is defined about the axis of rotation; characterised in that the first assembly is configured to be positioned adjacent to the second assembly such that at least a portion of the planar remote center of motion device of the first assembly is offset from the axis of rotation of the rotational device of the first assembly.
A method of wireless communication at a user equipment, UE, comprising: receiving a configuration of a coverage enhancement, CE, level for the UE; characterized by identifying a downlink control information, DCI, format based at least in part on the CE level, wherein the CE level corresponds to a modulation and coding scheme, MCS, information field, and wherein the DCI format is based at least in part on the MCS information field; and receiving a downlink control channel based at least in part on the DCI format. receiving a configuration of a coverage enhancement, CE, level for the UE; characterized by identifying a downlink control information, DCI, format based at least in part on the CE level, wherein the CE level corresponds to a modulation and coding scheme, MCS, information field, and wherein the DCI format is based at least in part on the MCS information field; and receiving a downlink control channel based at least in part on the DCI format.
A terminal, comprising: a touch-screen display configured to be touched by a user; and a controller configured to: display a text message; when two or more pointers are touch-dragged from a drag-starting position to a drag-ending position on the touch-screen display across a portion of the text message being displayed on the touch-screen display, determine a number of the touched pointers, wherein the touch-dragged pointers are simultaneously touched on the touch-screen display; and delete two or more lines of the text message between the drag-starting position and the drag-ending position at the same time based on the determined number of the touch-dragged pointers; wherein the controller is further configured to, delete the same number of lines of the text message as the determined number of the touch-dragged pointers at the same time. a touch-screen display configured to be touched by a user; and a controller configured to: display a text message; when two or more pointers are touch-dragged from a drag-starting position to a drag-ending position on the touch-screen display across a portion of the text message being displayed on the touch-screen display, determine a number of the touched pointers, wherein the touch-dragged pointers are simultaneously touched on the touch-screen display; and delete two or more lines of the text message between the drag-starting position and the drag-ending position at the same time based on the determined number of the touch-dragged pointers; display a text message; when two or more pointers are touch-dragged from a drag-starting position to a drag-ending position on the touch-screen display across a portion of the text message being displayed on the touch-screen display, determine a number of the touched pointers, wherein the touch-dragged pointers are simultaneously touched on the touch-screen display; and delete two or more lines of the text message between the drag-starting position and the drag-ending position at the same time based on the determined number of the touch-dragged pointers; wherein the controller is further configured to, delete the same number of lines of the text message as the determined number of the touch-dragged pointers at the same time.
An identification feature for identification of an object with a random structure formed from a dye or of particles of at least one colorant, wherein in a defined limited area of the identification feature at least two identification elements (02, 03) are arranged, wherein a first identification element is formed by a printing colour or an ink, wherein a second identification element is formed by the random structure formed from the pigments of a dye or from the particles of at least one colorant, wherein the pigments of the dye or the particles of the at least one colorant of the printing colour or ink of the first identification element are each dispersed in a first dispersant, and wherein the pigments of the dye or the particles of the at least one colorant of the second identification element are each dispersed in a second dispersant, characterized in that the first dispersant and the second dispersant differ from each other in material.
A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein: R 1 is carbonyl-R a, where R a is selected from: R 2 is hydrogen or substituted or unsubstituted C 1-6 alkyl; R 3 is carbonyl-R b or sulfonyl-R b, where R b is selected from: and n is 1, 2, 3, or 4. R 1 is carbonyl-R a, where R a is selected from: R 2 is hydrogen or substituted or unsubstituted C 1-6 alkyl; R 3 is carbonyl-R b or sulfonyl-R b, where R b is selected from: and n is 1, 2, 3, or 4.
Counterweight for an elevator system, wherein the counterweight has an asymmetrical cross-section in a horizontal sectional plane, wherein the counterweight has a first and a second longitudinal flank (21, 23), which each extend between a first and a second end face (17, 19), in particular the first longitudinal flank is substantially perpendicular to the first end face and to the second end face, wherein, on the counterweight, between the first end face and the second end face, an intermediate region is formed in which the counterweight has a smaller width than a first width on the first end face, wherein, in the intermediate region, a holding device is arranged on the counterweight, by means of which the counterweight can be attached to a guide rail and moved along the guide rail in a guided manner, characterized in that the first longitudinal flank runs substantially as a plane from the first end face to the second end face.
Pinch valve, for insertion in pneumatically or mechanically-actuated devices, comprising a hollow substantially cylindrical main body extending longitudinally, comprising end areas defining abutment surfaces (11a, 11b) that extend on a plane substantially perpendicular to the longitudinal axis of said cylindrical main body and also comprising a longitudinal axial opening, wherein said axial opening, on a transverse plane, has a substantially elliptical inner profile defined by the union of two arcs of circumference (21a, 21b), wherein on said main body it comprises at least one narrowing area defined by the joining of two conical tapered segments (13a, 13b), said main body comprises, at each end area, a first cylindrical segment (10a, 10b), each of said first cylindrical segments (10a, 10b) having a corresponding one of said conical tapered segments (13a, 13b) joined to it, characterised in that radial ribs (14a, 14b) extend radially from the two arcs of circumference (21a, 21b), said radial ribs (14a, 14b) being arranged longitudinally with tapered profile, having greater width at the narrowing area of said main body and said radial ribs (14a, 14b) having a tapered cross section towards the centre of the main body, at said narrowing area, with joining areas (15a, 15b).
Baking oven having an oven housing, an oven muffle as well as an illumination device for a treatment chamber of the baking oven formed by the oven muffle with at least one light source which is arranged outside the treatment chamber, yet assigned to the treatment chamber and emitting light, and which is subject to high levels of heat, wherein the light source and/or the support (9, 15) thereof has a direct connection with a heat-dissipating heat sink which conducts heat well, characterised in that the heat sink is formed by a metal wall of the oven housing covering the oven muffle surrounding the treatment chamber at a distance, and the heat sink has a metal connecting element bridging the gap between heat sink and light source, which is connected to the support (9, 15) of the light source or which itself is a support of the light source.
Method for operating a communication network for network devices that are coupled to the communication network, wherein a respective network device comprises a switch device, a first and a second control device (2, 3), which are coupled to the switch device, and wherein the switch device has a respective reception port (10, 14) and transmission port (9, 13) for the first and second control devices (2, 3) for the purpose of sending and receiving data via the communication network, wherein the method comprises: production of first data by the first control device and second data by the second control device, wherein the first data and the second data are linked to one another by a prescribed coding; sending of the first data from the first control device via the switch device to the second control device and sending of the second data from the second control device via the switch device to the first control device; sending of the first data and the second data via a first communication path (CB1, CB2, CB3) from the transmission port of the switch device for the first control device to the reception port of the switch device for the second control device; sending of the first data and the second data via a second communication path (CR1, CR2, CR3) from the transmission port of the switch device for the second control device to the reception port of the switch device for the first control device; wherein the data on the first and second communication paths (CB1, CB2, CB3, CR1, CR2, CR3) pass through the same network devices (200, 300) in opposite directions. production of first data by the first control device and second data by the second control device, wherein the first data and the second data are linked to one another by a prescribed coding; sending of the first data from the first control device via the switch device to the second control device and sending of the second data from the second control device via the switch device to the first control device; sending of the first data and the second data via a first communication path (CB1, CB2, CB3) from the transmission port of the switch device for the first control device to the reception port of the switch device for the second control device; sending of the first data and the second data via a second communication path (CR1, CR2, CR3) from the transmission port of the switch device for the second control device to the reception port of the switch device for the first control device; wherein the data on the first and second communication paths (CB1, CB2, CB3, CR1, CR2, CR3) pass through the same network devices (200, 300) in opposite directions.
A mixer for use in a microfluidic separation system, comprising: a mixing well; a distribution well for receiving an incoming flow of solvent composition; and characterized by a contoured surface disposed between the distribution and mixing wells, the contoured surface having a plurality of fluidic paths extending from the distribution well to the mixing well, each fluidic path passing through a different valley defined by opposing upwardly sloping banks, the incoming flow of solvent composition splitting at the distribution well into as many streams as fluidic paths, the streams recombining at the mixing well to produce an output compositional stream, wherein neighboring valleys abut at a ridgeline, and solvent composition can overflow said ridgeline. a mixing well; a distribution well for receiving an incoming flow of solvent composition; and characterized by a contoured surface disposed between the distribution and mixing wells, the contoured surface having a plurality of fluidic paths extending from the distribution well to the mixing well, each fluidic path passing through a different valley defined by opposing upwardly sloping banks, the incoming flow of solvent composition splitting at the distribution well into as many streams as fluidic paths, the streams recombining at the mixing well to produce an output compositional stream, wherein neighboring valleys abut at a ridgeline, and solvent composition can overflow said ridgeline.
Rotational speed display device for a motor vehicle comprising an intensified display for issuing warnings about the rotational speed, wherein the device has an analogue rotational speed display instrument and a screen, characterized in that the screen and the analogue rotational speed display instrument can be seen by the driver in an overlapping fashion as a composite image, the intensified rotational speed warning on the screen is represented within the region of the analogue rotational speed display instrument of the composite image, the analogue rotational speed display instrument is an analogue round instrument with a pitch-circle-shaped rotational speed scale and a pointer, the device has a semi-transparent mirror, wherein the screen is arranged behind the semi-transparent mirror, and the analogue rotational speed display instrument is reflected in the mirror, with the result that the screen is arranged in such a way that it is optically effective in the background of the analogue rotational speed display instrument.
A sensor assembly, comprising: a fastener body having a fastener end and a sensor end; characterized by a sensor substrate coupled with the sensor end of the fastener body, the sensor substrate including one or more conductive bodies and one or more first conductive pathways coupled with the one or more conductive bodies; and a sensor coupled with the sensor substrate and conductively coupled with the one or more conductive bodies by the one or more first conductive pathways, the sensor configured to sense humidity of air flowing through an air dryer, the one or more conductive bodies of the sensor substrate positioned to engage one or more second conductive pathways in the air dryer in different rotational positions of the fastener body relative to the air dryer. a sensor substrate coupled with the sensor end of the fastener body, the sensor substrate including one or more conductive bodies and one or more first conductive pathways coupled with the one or more conductive bodies; and a sensor coupled with the sensor substrate and conductively coupled with the one or more conductive bodies by the one or more first conductive pathways, the sensor configured to sense humidity of air flowing through an air dryer, the one or more conductive bodies of the sensor substrate positioned to engage one or more second conductive pathways in the air dryer in different rotational positions of the fastener body relative to the air dryer.
A method of washing fabric articles in a continuous batch tunnel washer (11, comprising the steps of: a) providing a continuous batch tunnel washer having an interior, an intake, a discharge, a plurality of modules, and a volume of liquid; b) moving the fabric articles from the intake to the modules in sequence; c) wherein in step "b" multiple of the modules define a dual use zone, namely a zone used for both washing and rinsing; d) adding a washing chemical to the volume of liquid in the dual use zone; e) not counter flowing a rinsing liquid in the washer interior for a selected time interval after step "d"; f) counter flowing a rinsing liquid in the washer interior along a flow path that is generally opposite the direction of travel of the fabric articles in steps "b" and "c"; and g) using a water extraction device to remove excess liquid after step "e". a) providing a continuous batch tunnel washer having an interior, an intake, a discharge, a plurality of modules, and a volume of liquid; b) moving the fabric articles from the intake to the modules in sequence; c) wherein in step "b" multiple of the modules define a dual use zone, namely a zone used for both washing and rinsing; d) adding a washing chemical to the volume of liquid in the dual use zone; e) not counter flowing a rinsing liquid in the washer interior for a selected time interval after step "d"; f) counter flowing a rinsing liquid in the washer interior along a flow path that is generally opposite the direction of travel of the fabric articles in steps "b" and "c"; and g) using a water extraction device to remove excess liquid after step "e".