A composition comprising i) a first peptide comprising the amino acid sequence LQPFPQPELPYPQPQ (SEQ ID NO: 13), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, ii) a second peptide comprising the amino acid sequence QPFPQPEQPFPWQP (SEQ ID NO: 14), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, and iii) a third peptide comprising the amino acid sequence PEQPIPEQPQPYPQQ (SEQ ID NO: 16), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived. i) a first peptide comprising the amino acid sequence LQPFPQPELPYPQPQ (SEQ ID NO: 13), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, ii) a second peptide comprising the amino acid sequence QPFPQPEQPFPWQP (SEQ ID NO: 14), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, and iii) a third peptide comprising the amino acid sequence PEQPIPEQPQPYPQQ (SEQ ID NO: 16), a biologically active fragment thereof no less than 7 amino acids in length and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived, or a biologically active variant thereof having no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating an equal or greater T cell response in a subject sensitive to gluten as the peptide from which it is derived.