A composition for use in treating skin diseases and skin conditions in a human patient in need of such treatment by topical dermatological application of a therapeutically effective amount of said composition comprising a compound according to Formula I, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystal forms, its individual tautomers or a pharmaceutically acceptable salt thereof, wherein R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H, C 1-10 alkyl, heterocycle or aryl; and R is C 1-10 alkyl, heterocycle or aryl, wherein "alkyl" means a saturated monovalent alkane moiety having straight or branched alkane moieties or combinations thereof, which may optionally be substituted by amino groups, aryl groups, halogens, and one methylene (-CH 2 -) can be replaced by carbonyl, -NH-, carboxyl, amide, sulfur or by oxygen, and "heterocycle" means an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic ring containing at least one heteroatom selected from O or N or S or combinations thereof, interrupting the carbocyclic ring structure, which may optionally be substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), - OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), - S(C 1-6 alkyl) groups, and "aryl" means an organic moiety derived from an aromatic hydrocarbon consisting of a monocyclic or bicyclic ring containing 6-10 carbon atoms by removal of one hydrogen atom, such as phenyl or naphthyl, which may optionally be substituted by, but not limited to, C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), - OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), and -S(C 1-6 alkyl) groups; and wherein said skin diseases and skin conditions are selected from: rosacea, sunburn, chronic sun damage, discreet erythemas, psoriasis, atopic dermatitis, menopause-associated hot flashes, hot flashes resulting from orchiectomy, atopic dermatitis, photoaging, seborrheic dermatitis, acne, allergic dermatitis, and irritant dermatitis. R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H, C 1-10 alkyl, heterocycle or aryl; and R is C 1-10 alkyl, heterocycle or aryl, wherein "alkyl" means a saturated monovalent alkane moiety having straight or branched alkane moieties or combinations thereof, which may optionally be substituted by amino groups, aryl groups, halogens, and one methylene (-CH 2 -) can be replaced by carbonyl, -NH-, carboxyl, amide, sulfur or by oxygen, and "heterocycle" means an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic ring containing at least one heteroatom selected from O or N or S or combinations thereof, interrupting the carbocyclic ring structure, which may optionally be substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), - OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), - S(C 1-6 alkyl) groups, and "aryl" means an organic moiety derived from an aromatic hydrocarbon consisting of a monocyclic or bicyclic ring containing 6-10 carbon atoms by removal of one hydrogen atom, such as phenyl or naphthyl, which may optionally be substituted by, but not limited to, C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), - OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), and -S(C 1-6 alkyl) groups; and