A system for collecting plasma, comprising: a venipuncture needle for drawing whole blood from a donor; a blood separator for separating the whole blood into anticoagulated plasma and a second blood component comprising red blood cells, the blood separator having a plasma output port connected to a plasma line for sending the anticoagulated plasma to an anticoagulated plasma collection container; a donor line fluidly connected to the venipuncture needle for introducing the whole blood from the donor to the separator, flow through the donor line being controlled by a first pump; an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the whole blood from the donor at a specific ratio; and a controller configured to control operation of the blood separator and the first pump, wherein the controller is configured to receive donor parameters electronically from a donor management system, wherein (a) the controller is configured to, prior to an initial draw phase, calculate a target volume for raw plasma and/or anticoagulated plasma to be collected based, at least in part, on donor parameters comprising weight and height, used to calculate total donor blood volume, and hematocrit (Hct), used to calculate total donor plasma volume, or (b) the donor management system is programmed to calculate the target volume for raw plasma and/or anticoagulated plasma to be collected based, at least in part, on donor parameters comprising weight and height, used to calculate total donor blood volume, and hematocrit (Hct), used to calculate total donor plasma volume and to send it to the controller; wherein the controller is further configured to control the system to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the anticoagulated plasma and the second blood component and to return the second blood component to the donor, wherein raw plasma is plasma without anticoagulant; and wherein the controller is further configured to operate the draw and return phases until a volume of raw plasma (V RP) in the collection container equals the target volume of raw plasma, the volume of raw plasma (V RP) based on a measured volume of anticoagulated plasma (V PP), wherein K= V PP / V RP and K=(ACR ∗ (1-Hct/100)+1)/(ACR ∗ (1-Hct/100)), wherein ACR is an anticoagulant ratio. a venipuncture needle for drawing whole blood from a donor; a blood separator for separating the whole blood into anticoagulated plasma and a second blood component comprising red blood cells, the blood separator having a plasma output port connected to a plasma line for sending the anticoagulated plasma to an anticoagulated plasma collection container; a donor line fluidly connected to the venipuncture needle for introducing the whole blood from the donor to the separator, flow through the donor line being controlled by a first pump; an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the whole blood from the donor at a specific ratio; and a controller configured to control operation of the blood separator and the first pump, wherein the controller is configured to receive donor parameters electronically from a donor management system, wherein (a) the controller is configured to, prior to an initial draw phase, calculate a target volume for raw plasma and/or anticoagulated plasma to be collected based, at least in part, on donor parameters comprising weight and height, used to calculate total donor blood volume, and hematocrit (Hct), used to calculate total donor plasma volume, or (b) the donor management system is programmed to calculate the target volume for raw plasma and/or anticoagulated plasma to be collected based, at least in part, on donor parameters comprising weight and height, used to calculate total donor blood volume, and hematocrit (Hct), used to calculate total donor plasma volume and to send it to the controller; wherein the controller is further configured to control the system to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the anticoagulated plasma and the second blood component and to return the second blood component to the donor, wherein raw plasma is plasma without anticoagulant; and wherein the controller is further configured to operate the draw and return phases until a volume of raw plasma (V RP) in the collection container equals the target volume of raw plasma, the volume of raw plasma (V RP) based on a measured volume of anticoagulated plasma (V PP), wherein K= V PP / V RP and K=(ACR ∗ (1-Hct/100)+1)/(ACR ∗ (1-Hct/100)), wherein ACR is an anticoagulant ratio.