A method, comprising: providing a test element configured for analyzing first and second analytes in a sample; providing a hand held device comprising a display, a processor and a storage memory, the device being operative to engage one or more test elements and to determine concentration of at least first and second analytes in a fluid sample provided on said one or more test elements; contacting the test element with the sample; determining concentration of the second analyte in the sample; determining concentration of the first analyte in the sample, using the device, recording in the storage memory the value of the determined concentration of each of the at least first and second analytes; using the device, determining whether the determined concentration for the first analyte is above a first predetermined value; using the device, determining whether the determined concentration for the second analyte is above a second predetermined value; and using the device, activating a watch mode when the determined concentration for either of the first and second analytes is above the respective first and second predetermined values, wherein the first analyte is hydroxybutyrate and the second analyte is glucose; wherein the concentration of said at least first and second analytes is determined electrochemically; and wherein activating said watch mode comprises - recommending and/or prompting a user to test hydroxybutyrate every 4-6 hours; - displaying measured glucose and hydroxybutyrate levels regardless of their relationship with any pre-specified values upon initiation of and during the watch mode; and/or - starting a new trending set of data to determine if hydroxybutyrate levels are beginning to rise even if still below the threshold of a high hydroxybutyrate level. providing a test element configured for analyzing first and second analytes in a sample; providing a hand held device comprising a display, a processor and a storage memory, the device being operative to engage one or more test elements and to determine concentration of at least first and second analytes in a fluid sample provided on said one or more test elements; contacting the test element with the sample; determining concentration of the second analyte in the sample; determining concentration of the first analyte in the sample, using the device, recording in the storage memory the value of the determined concentration of each of the at least first and second analytes; using the device, determining whether the determined concentration for the first analyte is above a first predetermined value; using the device, determining whether the determined concentration for the second analyte is above a second predetermined value; and using the device, activating a watch mode when the determined concentration for either of the first and second analytes is above the respective first and second predetermined values, wherein the first analyte is hydroxybutyrate and the second analyte is glucose; wherein the concentration of said at least first and second analytes is determined electrochemically; and wherein activating said watch mode comprises - recommending and/or prompting a user to test hydroxybutyrate every 4-6 hours; - displaying measured glucose and hydroxybutyrate levels regardless of their relationship with any pre-specified values upon initiation of and during the watch mode; and/or - starting a new trending set of data to determine if hydroxybutyrate levels are beginning to rise even if still below the threshold of a high hydroxybutyrate level. - recommending and/or prompting a user to test hydroxybutyrate every 4-6 hours; - displaying measured glucose and hydroxybutyrate levels regardless of their relationship with any pre-specified values upon initiation of and during the watch mode; and/or - starting a new trending set of data to determine if hydroxybutyrate levels are beginning to rise even if still below the threshold of a high hydroxybutyrate level.