A system for registering an atlas image from an atlas of multidimensional images with an objective image, the atlas image having been computed based on a plurality of training images, and the system comprising: - a generation unit for generating a candidate transformation based on a candidate transformation field for transforming a first region of the atlas image, wherein the first region comprises a plurality of landmarks, each training image from the plurality of training images comprises the plurality of landmarks, and wherein the candidate transformation field is defined by elementary transformation fields each being derived from displacements of i) the plurality of landmarks in a respective one of the plurality of training images, relative to ii) landmark position in the atlas image, wherein the candidate transformation is a linear combination of the elementary transformation fields, and wherein the each elementary transformation field is computed based on the principal component analysis of said displacements of the plurality of landmarks; - a transformation unit for transforming the first region of the atlas image using the candidate transformation; - a similarity unit for computing a measure of similarity of the transformed first region of the atlas image and a corresponding first region of the objective image; - an evaluation unit for evaluating the candidate transformation using a criterion based on the computed measure of similarity and determining an optimal transformation based on the evaluation of the candidate transformation; - an extension unit for extending the optimal transformation of the first region of the atlas image to a second region of the atlas image, wherein the second region comprises the first region, thereby creating a registration transformation; and - a registration unit for transforming the second region using the registration transformation, thereby registering the atlas image with the objective image. - a generation unit for generating a candidate transformation based on a candidate transformation field for transforming a first region of the atlas image, wherein the first region comprises a plurality of landmarks, each training image from the plurality of training images comprises the plurality of landmarks, and wherein the candidate transformation field is defined by elementary transformation fields each being derived from displacements of i) the plurality of landmarks in a respective one of the plurality of training images, relative to ii) landmark position in the atlas image, wherein the candidate transformation is a linear combination of the elementary transformation fields, and wherein the each elementary transformation field is computed based on the principal component analysis of said displacements of the plurality of landmarks; - a transformation unit for transforming the first region of the atlas image using the candidate transformation; - a similarity unit for computing a measure of similarity of the transformed first region of the atlas image and a corresponding first region of the objective image; - an evaluation unit for evaluating the candidate transformation using a criterion based on the computed measure of similarity and determining an optimal transformation based on the evaluation of the candidate transformation; - an extension unit for extending the optimal transformation of the first region of the atlas image to a second region of the atlas image, wherein the second region comprises the first region, thereby creating a registration transformation; and - a registration unit for transforming the second region using the registration transformation, thereby registering the atlas image with the objective image.