Method for generating adapted control instructions for a material extrusion process included in a fabrication process of a three-dimensional object, the adapted control instructions comprising at least one of spatially compensated electronic toolpaths, spatially compensated electronic slices, and other instructions by which a controller or control unit is enabled to control an ME system to perform the fabrication of the 3D-object from deposition of feedstock material up to and including post-processing, including annealing of the fabricated 3D-object, the method comprising: • obtaining an electronic 3D-model of the 3D-object to be fabricated; • generating control instructions based on said electronic 3D-model and process parameters of said fabrication process, wherein said process parameters include ME process parameters relating to the ME process and process parameters relating to post-processing of the 3D-object; • determining a mesh model representing said electronic 3D-model, the mesh model comprising interlinked mesh elements which interact using mathematical relationships based on ME process parameters, each mesh element having at least one property associated with at least one physical property of the 3D-object, said at least one property being mathematically affected by at least one of said ME process parameters; • performing simulation of said fabrication process in time using said control instructions, said mesh model and said process parameters comprising: ∘ establishing a deviation of said at least one property relative to a reference thereof for each element of the mesh model, wherein said deviation is induced by at least one of said process parameters; ∘ determining an adaptation for said at least one property of said each element of the mesh model to compensate for said deviation; • applying said adaptation to said control instructions to obtain at least one adapted control instruction allowing fabrication of the 3D-object that remains accurate to the electronic 3D-model after at least one of cooling down to room temperature at the end of the fabrication process and during use of the printed 3D-object in accordance with specifications for use of the 3D-object. • obtaining an electronic 3D-model of the 3D-object to be fabricated; • generating control instructions based on said electronic 3D-model and process parameters of said fabrication process, wherein said process parameters include ME process parameters relating to the ME process and process parameters relating to post-processing of the 3D-object; • determining a mesh model representing said electronic 3D-model, the mesh model comprising interlinked mesh elements which interact using mathematical relationships based on ME process parameters, each mesh element having at least one property associated with at least one physical property of the 3D-object, said at least one property being mathematically affected by at least one of said ME process parameters; • performing simulation of said fabrication process in time using said control instructions, said mesh model and said process parameters comprising: ∘ establishing a deviation of said at least one property relative to a reference thereof for each element of the mesh model, wherein said deviation is induced by at least one of said process parameters; ∘ determining an adaptation for said at least one property of said each element of the mesh model to compensate for said deviation; ∘ establishing a deviation of said at least one property relative to a reference thereof for each element of the mesh model, wherein said deviation is induced by at least one of said process parameters; ∘ determining an adaptation for said at least one property of said each element of the mesh model to compensate for said deviation; • applying said adaptation to said control instructions to obtain at least one adapted control instruction allowing fabrication of the 3D-object that remains accurate to the electronic 3D-model after at least one of cooling down to room temperature at the end of the fabrication process and during use of the printed 3D-object in accordance with specifications for use of the 3D-object.