mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula IAX or a pharmaceutically acceptable salt thereof, wherein: X represents F or Cl; R 1 represents C 1-12 alkyl, C 2-12 alkenyl or C 2-12 alkynyl optionally substituted by one or more halo; R 2 and R 3 each independently represent H or C 1-3 alkyl, C 2-3 alkenyl or C 2-3 alkynyl optionally substituted by one or more halo; and or R 2 and R 3 may be linked together to form, together with the carbon atom to which they are attached, a 3- to 6-membered ring, which ring optionally is substituted by one or more groups independently selected from halo and C 1 alkyl optionally substituted by one or more halo, wherein alkyl, alkenyl and alkynyl groups may be straight-chain or, when there is a sufficient number of carbon atoms, be branched-chain, and/or cyclic or part cyclic. X represents F or Cl; R 1 represents C 1-12 alkyl, C 2-12 alkenyl or C 2-12 alkynyl optionally substituted by one or more halo; R 2 and R 3 each independently represent H or C 1-3 alkyl, C 2-3 alkenyl or C 2-3 alkynyl optionally substituted by one or more halo; and or R 2 and R 3 may be linked together to form, together with the carbon atom to which they are attached, a 3- to 6-membered ring, which ring optionally is substituted by one or more groups independently selected from halo and C 1 alkyl optionally substituted by one or more halo, wherein alkyl, alkenyl and alkynyl groups may be straight-chain or, when there is a sufficient number of carbon atoms, be branched-chain, and/or cyclic or part cyclic.
An integrated power electric unit mounted on an electric vehicle, comprising: a first power electric unit in an inverter casing; a second power electric unit in a Power Distribution Module, PDM, casing arranged over the inverter casing of the first power electric unit in a vertical direction of the vehicle; a first channel that connects the inverter casing and the PDM casing of the first and second power electric units (20, 30) so as to flow the air; a breather provided in the PDM casing of the second power electric unit to cause inner and outer sides of the PDM casing of the second power electric unit to communicate with each other; a third power electric unit in a motor casing arranged under the inverter casing of the first power electric unit in a vertical direction of the vehicle; a second channel that connects the inverter casing and the motor casing of the first and third power electric units (20, 10) so as to flow the air; and a cooler arranged between the first and second channels (420, 410) wherein the breather is located in the PDM casing having the highest position of the casings in a vertical direction of the vehicle. a first power electric unit in an inverter casing; a second power electric unit in a Power Distribution Module, PDM, casing arranged over the inverter casing of the first power electric unit in a vertical direction of the vehicle; a first channel that connects the inverter casing and the PDM casing of the first and second power electric units (20, 30) so as to flow the air; a breather provided in the PDM casing of the second power electric unit to cause inner and outer sides of the PDM casing of the second power electric unit to communicate with each other; a third power electric unit in a motor casing arranged under the inverter casing of the first power electric unit in a vertical direction of the vehicle; a second channel that connects the inverter casing and the motor casing of the first and third power electric units (20, 10) so as to flow the air; and a cooler arranged between the first and second channels (420, 410) wherein the breather is located in the PDM casing having the highest position of the casings in a vertical direction of the vehicle.
Method for treating, by filtration, haemorrhagic fluid contained in a container with a view to subsequent autotransfusion, comprising at least one step of concentrating by filtration said haemorrhagic fluid in order to increase the concentration of red blood cells in the haemorrhagic fluid to reach a target haematocrit level while at the same time removing from the haemorrhagic fluid a filtrate comprising compounds not desired for autotransfusion, characterised in that it further comprises the following steps: - a preliminary step of measuring the haematocrit level of the haemorrhagic fluid; and - a dilution step consisting in adding to the volume of haemorrhagic fluid to be treated a determined volume of dilution fluid, said determined volume of dilution fluid being calculated as a function of the measured haematocrit level of said haemorrhagic fluid and the target haematocrit level. - a preliminary step of measuring the haematocrit level of the haemorrhagic fluid; and - a dilution step consisting in adding to the volume of haemorrhagic fluid to be treated a determined volume of dilution fluid, said determined volume of dilution fluid being calculated as a function of the measured haematocrit level of said haemorrhagic fluid and the target haematocrit level.
An apparatus (410, 510, 710) comprising: (a) a platform (418, 518, 718) including an upper support and a lower support; (b) an adjunct material positioned on the upper support, wherein the upper support is configured to move relative to the lower support in a direction toward a jaw of an end effector (12, 612, 712) of a surgical stapler to apply the adjunct material to the jaw; and (c) an engagement feature (440, 540, 740), wherein the engagement feature (440, 540, 740) is configured to interact with a predetermined portion (48, 630, 840) of the end effector (12, 612, 812) to permit movement of the upper support relative to the lower support and thereby apply the adjunct material to the jaw of the end effector, characterised in that the engagement feature (440, 540, 740) is configured to inhibit movement of the upper support relative to the lower support when the engagement feature (440, 540, 740) is disengaged from the predetermined portion (48, 630, 840) of the end effector (12, 612, 812). (a) a platform (418, 518, 718) including an upper support and a lower support; (b) an adjunct material positioned on the upper support, wherein the upper support is configured to move relative to the lower support in a direction toward a jaw of an end effector (12, 612, 712) of a surgical stapler to apply the adjunct material to the jaw; and (c) an engagement feature (440, 540, 740), wherein the engagement feature (440, 540, 740) is configured to interact with a predetermined portion (48, 630, 840) of the end effector (12, 612, 812) to permit movement of the upper support relative to the lower support and thereby apply the adjunct material to the jaw of the end effector, characterised in that the engagement feature (440, 540, 740) is configured to inhibit movement of the upper support relative to the lower support when the engagement feature (440, 540, 740) is disengaged from the predetermined portion (48, 630, 840) of the end effector (12, 612, 812).
A profile assembly having a frame profile and a pivotally attached wing profile, preferably a window or door profile assembly, wherein the frame profile and the wing profile are each formed of an outer and inner profile half-shell (11, 12, 21, 22), wherein the respective profile half-shells (11, 12, 21, 22) are in each case connected to each other by means of at least one insulating bar (13, 23), wherein a gap is formed in the abutment region between the frame profile and wing profile, and wherein at least one gap covering device (30, 30a, 30b) having at least one fastening element (31, 31a, 31b, 32, 32a, 32b) for attaching to one of the profile half-shells (11, 12, 21, 22) and a flexible tab (33, 33a, 33b) is provided, same being designed so as to cover the entire open area of the gap and fit over a region of a limit stop of the opposite profile so as to hinder a pressing in the closed position, characterized in that the flexibility of the at least one gap covering device tab is configured by way of an appropriate material selection so as to enable a largely unobstructed opening and closing of the pivotally attached wing profile on the frame profile, and wherein the gap covering device serves as a pinch protector.
A method of installing a seal in a bore of a component, the method comprising opening a tool case to reveal a support fixture with a shaped groove configured to receive a component flange and permit rotation of the component relative to the tool case; rotating the component in the support fixture while a portion of the component flange remains within the shaped groove; securing a base plate to the component; arranging the seal onto a pusher; inserting the pusher into a hole in the base plate; installing a hub onto the base plate and over the pusher; and rotating a rod relative to the hub to advance the pusher and seat the seal in the bore. opening a tool case to reveal a support fixture with a shaped groove configured to receive a component flange and permit rotation of the component relative to the tool case; rotating the component in the support fixture while a portion of the component flange remains within the shaped groove; securing a base plate to the component; arranging the seal onto a pusher; inserting the pusher into a hole in the base plate; installing a hub onto the base plate and over the pusher; and rotating a rod relative to the hub to advance the pusher and seat the seal in the bore.
Retaining device to retain in position a karabiner in a loop of a sling, the device comprising a hollow body having a first opening from which a first substantially straight channel extends for the insertion of a part of the sling provided with the loop inside the hollow body, and a second opening and a third opening connected one to another through a second channel for the passage of the karabiner, wherein the second channel for the passage of the karabiner extends along a path at least partially curved between said second opening and said third opening, wherein the hollow body comprises an abutment wall arranged substantially opposing said first opening, and designed to retain at least part of the loop of the sling inside the hollow body, said abutment wall being in an intermediate position between said second opening and said third opening (12b, 12c) along the second channel for the passage of the karabiner.
An assistive flexible suit system for assisting motion of a wearer, the assistive flexible suit system comprising: a suspension anchor (302, 304, 306) configured to mount to the body of the wearer and transmit loads to one or more predetermined load-bearing segments of the body of the wearer; a foot module configured to mount on or adjacent to a foot of the wearer and transmit loads to a hindfoot segment or a forefoot segment, or both, of the foot of the wearer; an actuator attached to the foot module, the actuator being selectively actuable to generate tension between the foot module and the suspension anchor (302, 304, 306); a sensor mounted on or proximate the foot of the wearer and operable to detect a gait characteristic of the wearer and output a signal indicative thereof; a controller communicatively connected to the sensor and the actuator, the controller being configured to analyze the gait characteristic signal output by the sensor and, based at least in part on the analyzed signal, selectively actuate the actuator to thereby assist plantar flexion or dorsiflexion, or both, of the foot of the wearer; and a tensioning element (308A, 308B) attaching the suspension anchor (302, 304, 306) to the foot module, the tensioning element (308A, 308B) being configured to generate tension between the foot module and the suspension anchor (302, 304, 306) to thereby assist plantar flexion, dorsiflexion, inversion, eversion, pronation, supination, or any combination thereof, of the foot of the wearer. a suspension anchor (302, 304, 306) configured to mount to the body of the wearer and transmit loads to one or more predetermined load-bearing segments of the body of the wearer; a foot module configured to mount on or adjacent to a foot of the wearer and transmit loads to a hindfoot segment or a forefoot segment, or both, of the foot of the wearer; an actuator attached to the foot module, the actuator being selectively actuable to generate tension between the foot module and the suspension anchor (302, 304, 306); a sensor mounted on or proximate the foot of the wearer and operable to detect a gait characteristic of the wearer and output a signal indicative thereof; a controller communicatively connected to the sensor and the actuator, the controller being configured to analyze the gait characteristic signal output by the sensor and, based at least in part on the analyzed signal, selectively actuate the actuator to thereby assist plantar flexion or dorsiflexion, or both, of the foot of the wearer; and a tensioning element (308A, 308B) attaching the suspension anchor (302, 304, 306) to the foot module, the tensioning element (308A, 308B) being configured to generate tension between the foot module and the suspension anchor (302, 304, 306) to thereby assist plantar flexion, dorsiflexion, inversion, eversion, pronation, supination, or any combination thereof, of the foot of the wearer.
A control system for a vehicle, the control system comprising one or more controllers, wherein the control system is configured to: in a first operating mode, control a loudspeaker system of the vehicle to direct audio output into a cabin of the vehicle; and in a second, user-requestable operating mode, control the loudspeaker system of the vehicle to direct audio output to a vehicle-rearward location relative to the audio output in the first operating mode, wherein the second operating mode requires a rear tailgate closure of a rear cargo area of the vehicle to be opened, characterized in that, in the first operating mode, one or more functions are enabled and, in the second operating mode, the one or more functions are inhibited, wherein the one or more functions include at least one of: access to the loudspeaker system by a telephony function; access to a vehicle cabin microphone by the telephony function; a hands-free powered tailgate request function that is configured to initiate powered closing and/or opening of the rear tailgate closure by a rear tailgate power mechanism in dependence on a detected hands-free user action; and a proximity-based vehicle locking function. in a first operating mode, control a loudspeaker system of the vehicle to direct audio output into a cabin of the vehicle; and in a second, user-requestable operating mode, control the loudspeaker system of the vehicle to direct audio output to a vehicle-rearward location relative to the audio output in the first operating mode, wherein the second operating mode requires a rear tailgate closure of a rear cargo area of the vehicle to be opened, characterized in that, in the first operating mode, one or more functions are enabled and, in the second operating mode, the one or more functions are inhibited, wherein the one or more functions include at least one of: access to the loudspeaker system by a telephony function; access to a vehicle cabin microphone by the telephony function; a hands-free powered tailgate request function that is configured to initiate powered closing and/or opening of the rear tailgate closure by a rear tailgate power mechanism in dependence on a detected hands-free user action; and a proximity-based vehicle locking function. access to the loudspeaker system by a telephony function; access to a vehicle cabin microphone by the telephony function; a hands-free powered tailgate request function that is configured to initiate powered closing and/or opening of the rear tailgate closure by a rear tailgate power mechanism in dependence on a detected hands-free user action; and a proximity-based vehicle locking function.
A vane assembly comprising: a rotatable airfoil extending between a radially inner platform and a radially outer platform having a leading edge and a trailing edge; and a thrust projection fixed relative to the rotatable airfoil, wherein the thrust projection includes a first outer thrust surface for supporting radial loads in a first outer radial direction and a second inner thrust surface for supporting radial inward loads in a second radial direction, characterised in that: the assembly further comprises a fixed airfoil portion extending between the radially inner platform and the radially outer platform having a leading edge and a trailing edge, wherein the rotatable airfoil is located aft of the fixed airfoil portion and the trailing edge of the fixed airfoil portion includes a concave surface. a rotatable airfoil extending between a radially inner platform and a radially outer platform having a leading edge and a trailing edge; and a thrust projection fixed relative to the rotatable airfoil, wherein the thrust projection includes a first outer thrust surface for supporting radial loads in a first outer radial direction and a second inner thrust surface for supporting radial inward loads in a second radial direction, characterised in that: the assembly further comprises a fixed airfoil portion extending between the radially inner platform and the radially outer platform having a leading edge and a trailing edge, wherein the rotatable airfoil is located aft of the fixed airfoil portion and the trailing edge of the fixed airfoil portion includes a concave surface.
A method of detecting or diagnosing gastric cancer in a subject, the method comprising: determining an expression level of at least hsa-miR-103a-3p in a non-cellular biofluid sample obtained from the subject, wherein downregulation of hsa-miR-103a-3p, as compared to the control, is indicative of the subject having stage 1 gastric cancer, and wherein the control is a gastric cancer free subject. determining an expression level of at least hsa-miR-103a-3p in a non-cellular biofluid sample obtained from the subject, wherein downregulation of hsa-miR-103a-3p, as compared to the control, is indicative of the subject having stage 1 gastric cancer, and wherein the control is a gastric cancer free subject.
A rotor blade (26, 30) for a turbomachine, the rotor blade (26, 30) comprising: a main body comprising a shank and an airfoil extending radially outwardly from the shank; a platform surrounding the main body, the platform comprising a slash face (56, 58); and a damper stack disposed at the slash face (56, 58) and extending generally along an axial direction, the damper stack comprising a plurality of damper pins, each of the plurality of damper pins in contact with a neighboring damper pin, wherein each of the plurality of damper pins extends between a first end and a second end, wherein the first end of a first damper pin contacts the second end of a second damper pin (72"); characterized in that: the first end of the first damper pin defines a convex spherical shape, and the second end of the second damper pin (72") defines a concave spherical shape. a main body comprising a shank and an airfoil extending radially outwardly from the shank; a platform surrounding the main body, the platform comprising a slash face (56, 58); and a damper stack disposed at the slash face (56, 58) and extending generally along an axial direction, the damper stack comprising a plurality of damper pins, each of the plurality of damper pins in contact with a neighboring damper pin, wherein each of the plurality of damper pins extends between a first end and a second end, wherein the first end of a first damper pin contacts the second end of a second damper pin (72"); characterized in that: the first end of the first damper pin defines a convex spherical shape, and the second end of the second damper pin (72") defines a concave spherical shape.
An apparatus for shaping plastics material pre-forms into plastics material containers with a movable carrier on which at least one shaping station for shaping the plastics material pre-forms into the plastics material containers is arranged, wherein the shaping station has a blow moulding device which forms a cavity inside which the plastics material pre-forms are capable of being shaped into the plastics material containers, and wherein the shaping station additionally has an actuation device which acts upon the plastics material pre-forms with a flowable medium for their expansion, wherein the shaping station additionally has a stretching rod which is capable of being inserted into the plastics material pre-forms in order to stretch them in the longitudinal direction thereof, wherein the shaping station has a drive device which moves the stretching rod with respect to the plastics material pre-form, wherein a coupling device is provided which couples a movement of the stretching rod with respect to the plastics material pre-form to a movement of the actuation device with respect to the plastics material pre-form - in particular in a mechanical manner - at least for a time, and the apparatus has an influencing device which influences a supply movement of the actuation device towards the plastics material pre-form at least in sections and/or at least for a time, characterized in that the influencing device is an influencing device which operates pneumatically and in that the influencing device has a throttle device which is capable of having gas flow through it and which throttles a supply movement of the actuation device to the plastics material preform at least for a time.
A method for producing a non-oriented electrical steel sheet by hot rolling and cold rolling a steel slab having a chemical composition comprising C: not more than 0.0050 mass%, Si: 2-7 mass%, Mn: 0.05-2.0 mass%, P: not more than 0.2 mass%, S: not more than 0.005 mass%, Al: not more than 3 mass%, N: not more than 0.005 mass%, Ti: not more than 0.003 mass%, Nb: not more than 0.005 mass%, V: not more than 0.005 mass%, optionally at least one of the following groups A-C: Group A: one or two selected from Sn: 0.005-0.20 mass% and Sb: 0.005-0.20 mass%; Group B: one or more selected from Ca: 0.001-0.010 mass%, Mg: 0.001-0.010 mass% and REM: 0.001-0.010 mass%; Group C: one or two selected from Cr: 0.01-0.5 mass% and Cu: 0.01-0.2 mass%, and the remainder being Fe and inevitable impurities and then subjecting the resultant sheet to a finish annealing and a stress-relief annealing, characterized in that conditions of the finish annealing and stress-relief annealing are adjusted so that a yield stress of the steel sheet after the finish annealing is not less than 400 MPa and a ratio (B 50S/ B 50H) of a magnetic flux density B 50S of the steel sheet subjected to the stress-relief annealing after the finish annealing to a magnetic flux density B 50H of the steel sheet after the finish annealing is not less than 0.99, and wherein a soaking temperature is 750-950°C and a soaking time is 0.1-10 hour and a heating rate from 600°C to the soaking temperature is not less than 8°C/min as the condition of the stress-relief annealing. Group A: one or two selected from Sn: 0.005-0.20 mass% and Sb: 0.005-0.20 mass%; Group B: one or more selected from Ca: 0.001-0.010 mass%, Mg: 0.001-0.010 mass% and REM: 0.001-0.010 mass%; Group C: one or two selected from Cr: 0.01-0.5 mass% and Cu: 0.01-0.2 mass%, and the remainder being Fe and inevitable impurities and then subjecting the resultant sheet to a finish annealing and a stress-relief annealing, characterized in that conditions of the finish annealing and stress-relief annealing are adjusted so that a yield stress of the steel sheet after the finish annealing is not less than 400 MPa and a ratio (B 50S/ B 50H) of a magnetic flux density B 50S of the steel sheet subjected to the stress-relief annealing after the finish annealing to a magnetic flux density B 50H of the steel sheet after the finish annealing is not less than 0.99, and wherein a soaking temperature is 750-950°C and a soaking time is 0.1-10 hour and a heating rate from 600°C to the soaking temperature is not less than 8°C/min as the condition of the stress-relief annealing.