mhurhangee/ep-ind-claims huggingface dataset:
A composition for use in a method of treating an ischemic disease to modulate expression of a target transcriptional product in an ischemic site of a subject, comprising a nucleic acid complex formed by annealing together a first nucleic acid strand comprising an antisense oligonucleotide region with respect to the target transcriptional product, and a lipid-conjugated second nucleic acid strand comprising a complementary region that is complementary to at least part of the first nucleic acid strand.
Arrangement for fastening a strip-shaped attachment part to a body part of a vehicle, with at least two holding elements (4, 5) which can be secured on the body part and are configured for holding the attachment part, wherein at least one of the holding elements (4, 5) can be secured/is secured on the body part by longitudinal displacement, characterized in that the holding elements (4, 5) each have at least one rear engagement element which can be brought/is brought by the longitudinal displacement into a rear engagement position with the attachment part for the fastening thereof.
An in vitro method for the diagnosis and/or prognosis of clear cell Renal Cell Carcinoma (ccRCC) in a subject suspected of suffering it, said method comprising the step of detecting in an isolated sample of the subject, the sample selected from the group consisting of renal tissue biopsy and cells from urine the presence of a protein Signal transducer and activator of transcription 3 (STAT3), wherein the Signal transducer and activator of transcription 3 (STAT3) comprises the amino acid sequence SEQ ID NO: 2, which comprises a phosphorylated serine residue in the position 727.
A central lubricating station for lubricating at least two machine parts, comprising: - a container base holding at least two replaceable containers, each replaceable container holding at least one type of lubricant; and - one or more pump(s) configured for pumping at least one type of lubricant interchangeably from the at least two replaceable containers to the at least two machine parts; and - a motor configured for driving the one or more pumps, wherein the container base is configured for transferring lubricant from one replaceable container to another replaceable container, such that lubricant in any of the containers is prevented from sedimenting. - a container base holding at least two replaceable containers, each replaceable container holding at least one type of lubricant; and - one or more pump(s) configured for pumping at least one type of lubricant interchangeably from the at least two replaceable containers to the at least two machine parts; and - a motor configured for driving the one or more pumps, wherein the container base is configured for transferring lubricant from one replaceable container to another replaceable container, such that lubricant in any of the containers is prevented from sedimenting.
Air outlet device comprising: - a supporting structure suitable to communicate, in use, with an air ventilation system: - an outlet member configured to emit an air flow along an outlet axis; - a coupling device which couples said outlet member to said supporting structure and comprises joint means (29,30) configured so as to permit a rotation of said outlet member by 180° about a joint axis orthogonal to said outlet axis, so that said outlet member can be placed in two opposite configurations; said outlet member comprising a plurality of deflector portions (18,19,20,21,25) comprising at least two ring-shaped walls (19,20), which are coaxial and axially spaced with respect to one another along said outlet axis; the deflector portions (18,19,20,21,25) defining a plurality of air ducts, which extend about said outlet axis and are arranged axially in sequence with respect to one another; said deflector portions (18,19,20,21,25) having shapes and/or positions such as to guide the air in said air ducts along guiding directions each having at least a radial component; characterized in that at least one of said ring-shaped walls has a series of through holes made in positions that are spaced apart about said outlet axis. - a supporting structure suitable to communicate, in use, with an air ventilation system: - an outlet member configured to emit an air flow along an outlet axis; - a coupling device which couples said outlet member to said supporting structure and comprises joint means (29,30) configured so as to permit a rotation of said outlet member by 180° about a joint axis orthogonal to said outlet axis, so that said outlet member can be placed in two opposite configurations;
A method for improving fairness among devices accessing a radio bandwidth, the devices including a mobile device (204A, 204B) using the radio bandwidth to access a radio access system using a channel access protocol, wherein the channel access protocol is a collision avoidance-type channel access protocol configured for using a back-off time before transmitting a retransmission, the method comprising: determining information by monitoring the radio bandwidth, the information comprising at least one of transmission statistics related to the radio bandwidth and information indicating channel free lengths and channel busy lengths; analyzing the information by determining, from the information, statistics corresponding to detected frame spacings between packets and determining an adjusted back-off time based on the statistics; and implementing, by the mobile device (204A, 204B), the adjusted back-off time before transmitting the retransmission over the radio bandwidth. determining information by monitoring the radio bandwidth, the information comprising at least one of transmission statistics related to the radio bandwidth and information indicating channel free lengths and channel busy lengths; analyzing the information by determining, from the information, statistics corresponding to detected frame spacings between packets and determining an adjusted back-off time based on the statistics; and implementing, by the mobile device (204A, 204B), the adjusted back-off time before transmitting the retransmission over the radio bandwidth.
Method for feeding reactive power into an AC voltage system by means of a modular multilevel converter, which comprises at least one series circuit having at least two series-connected submodules and an inductance, wherein each submodule has a respective separate intermediate circuit, wherein the reactive power generation is controlled depending on the intermediate circuit voltage (Uzk) of at least one of the intermediate circuits, characterized in that - the reactive power generation is reduced when the amplitude of a harmonic - based on the system frequency of the AC voltage system - of the intermediate circuit voltage (Uzk) reaches or exceeds a threshold value (ZSW, KSW), or - an average voltage value is ascertained, which indicates the average value of the intermediate circuit voltages (Uzk) of the intermediate circuits of all of the submodules at the respective time, and the reactive power generation is reduced when the amplitude of a harmonic of the average voltage value - based on the system frequency of the AC voltage system - reaches or exceeds a threshold value (ZSW, KSW). - the reactive power generation is reduced when the amplitude of a harmonic - based on the system frequency of the AC voltage system - of the intermediate circuit voltage (Uzk) reaches or exceeds a threshold value (ZSW, KSW), or - an average voltage value is ascertained, which indicates the average value of the intermediate circuit voltages (Uzk) of the intermediate circuits of all of the submodules at the respective time, and the reactive power generation is reduced when the amplitude of a harmonic of the average voltage value - based on the system frequency of the AC voltage system - reaches or exceeds a threshold value (ZSW, KSW).
Ophthalmological apparatus for treating eye tissue, comprising a laser source that is set up to produce a pulsed laser beam; a scanner system that is set up to direct the pulsed laser beam at a treatment speed in the eye tissue along a scanning treatment line (sb), and a first scanning apparatus which is connected upstream of the scanner system and is set up to deflect the pulsed laser beam, for producing a first additional scanning movement component (sm), in a first scanning direction (m) at a first scanning speed that is considerably higher as compared to the treatment speed, with the result that the first additional scanning movement component (sm) is superposed on the scanning treatment line (sb), characterized by a second scanning apparatus which is connected upstream of the scanner system and is set up to deflect the pulsed laser beam, for producing a second additional scanning movement component (sf), in a second scanning direction (f), which is at an angle to the first scanning direction (m) of the first additional scanning movement component (sm), at a second scanning speed that is considerably higher as compared to the first scanning speed, with the result that the second additional scanning movement component (sf) is superposed on the first additional scanning movement component (sm) and a scanning region (sa) is treated by the deflection of the pulsed laser beam with the first additional scanning movement component (sm) in the first scanning direction (m) and the superposed, second additional scanning movement component (sf) in the second scanning direction (f), and a circuit which is set up to control the scanner system in synchronized fashion with the first scanning apparatus and the second scanning apparatus such that the scanning region (sa) is traveled by the scanner system along the scanning treatment line (sb) and a tissue volume treatment is effected in the eye tissue.
A heavy duty tire comprising, a tread portion provided with a pair of crown main grooves disposed on both sides of the tire equator and extending continuously in the tire circumferential direction, and a pair of shoulder main grooves each disposed axially outside crown main grooves and extending continuously in the tire circumferential direction, a crown land portion between crown main grooves, a pair of middle land portions between crown main grooves and shoulder main grooves, a pair of shoulder land portions disposed axially outside of shoulder main grooves, wherein crown lateral grooves are provided on the crown land portion to form a plurality of crown blocks, middle lateral grooves are provided on middle land portions to form a plurality of middle blocks, shoulder lateral grooves are provided on shoulder land portions to form a plurality of shoulder blocks, characterized in that crown main grooves have groove widths in a range of from 2 to 5 % of a tread half width (TWh) which is an axial distance between the tire equator and a tread edge (Te), shoulder main grooves have groove widths in a range of from 6 to 9 % of the tread half width (TWh), an axial distance between the tire equator and a centerline of one of shoulder main grooves is in a range of from 52 to 68 % of the tread half width (TWh), crown lateral grooves and middle lateral grooves have groove widths (W3, W4) in a range of from 0.4 to 2.0 mm, and shoulder lateral grooves have groove widths in a range of from 6 to 9 % of the tread half width (TWh).
An apparatus for treating a tumor in a subject's body and facilitating delivery of a substance across cell membranes in the subject's body, the apparatus comprising: an AC voltage generator capable of generating an alternating electric field at a first frequency and a second frequency different to the first frequency, and having a control input, wherein the AC voltage generator is configured to output the alternating electric field at the first frequency when the control input is in a first state and at the second frequency when the control input is in a second state; and a controller programmed to (a) place the control input in the second state so that the AC voltage generator outputs the alternating electric field at the second frequency, (b) accept a request to switch the alternating electric field to the first frequency, (c) upon receipt of the request, place the control input in the first state so that the AC voltage generator outputs the alternating electric field at the first frequency for an interval of time, and (d) after the interval of time has elapsed, place the control input in the second state so that the AC voltage generator outputs the alternating electric field at the second frequency; characterized in that the first frequency is between 250 kHz and 350 kHz, and the second frequency is between 150 kHz and 250 kHz. an AC voltage generator capable of generating an alternating electric field at a first frequency and a second frequency different to the first frequency, and having a control input, wherein the AC voltage generator is configured to output the alternating electric field at the first frequency when the control input is in a first state and at the second frequency when the control input is in a second state; and a controller programmed to (a) place the control input in the second state so that the AC voltage generator outputs the alternating electric field at the second frequency, (b) accept a request to switch the alternating electric field to the first frequency, (c) upon receipt of the request, place the control input in the first state so that the AC voltage generator outputs the alternating electric field at the first frequency for an interval of time, and (d) after the interval of time has elapsed, place the control input in the second state so that the AC voltage generator outputs the alternating electric field at the second frequency; characterized in that the first frequency is between 250 kHz and 350 kHz, and the second frequency is between 150 kHz and 250 kHz.
A transformer assembly comprising a magnetic core, a substrate upon which a primary winding is wound, and a secondary winding; the primary winding having a spiral winding of insulated wire, the spiral winding having a pair of connected spiral sections, each spiral section wound on one side of the substrate, the first spiral section winding inwardly and gradually decreasing in diameter to a connection branch with the second spiral section and the second spiral section winding outwardly and gradually increasing in diameter from the connection branch so that both ends of the winding are accessible at the periphery of the winding, characterised in that the substrate is substantially horseshoe shaped with an open channel for through passage of a primary winding.
A process for loading ceramic particles having a spherical shape and a diameter ranging from 6 mm to 25 mm into a vertical reactor used in a chemical, petrochemical or petroleum refining process and having a diameter of at least 0.5m, which comprises: - introducing into the reactor a feeding pipe that is opened at its bottom part, said feeding pipe being vertical or having an angle of inclination with regard to vertical of at most 15 degrees, - inducing an upflow of air and/or nitrogen into said pipe from the bottom opening to the top thereof by using a vacuum system to suck air and/or nitrogen via a chamber attached to the top of the feeding pipe via a sealing clamp, and - once the air flow rate is established, pouring said ceramic particles into the pipe at the upper part thereof in such a way that said particles fall downwardly counter currently to said upflow of air and/or nitrogen, wherein the particles are fed into said pipe from a particle supply hopper, through a particle flow control device and then via chamber, characterized in that no physical device or air-supplying conduit is present inside the inner section of the feeding pipe, and in that the feeding pipe is introduced into the reactor so that the distance (d) between the lower exit of the pipe and the bottom of the reactor or the top of the particles bed in the case of a partially loaded reactor is at most 2 m. - introducing into the reactor a feeding pipe that is opened at its bottom part, said feeding pipe being vertical or having an angle of inclination with regard to vertical of at most 15 degrees, - inducing an upflow of air and/or nitrogen into said pipe from the bottom opening to the top thereof by using a vacuum system to suck air and/or nitrogen via a chamber attached to the top of the feeding pipe via a sealing clamp, and - once the air flow rate is established, pouring said ceramic particles into the pipe at the upper part thereof in such a way that said particles fall downwardly counter currently to said upflow of air and/or nitrogen, wherein the particles are fed into said pipe from a particle supply hopper, through a particle flow control device and then via chamber,
A molybdenum composite hybrid laminate comprising: a plurality of composite material layers; a plurality of surface treated molybdenum foil layers interweaved between the composite material layers, wherein the molybdenum foil layer is surface treated via one or more surface treatments selected from the group comprising sol gel surface treatment, water based sol gel paint, grit blasting, sanding, sandblasting, solvent wiping, abrading, chemical cleaning, laser ablation, and chemical etching; and a plurality of adhesive layers disposed between and bonding adjacent layers of the composite material layers and the molybdenum foil layers; and wherein two or more of the composite material layers each have a cutout portion of surface treated molybdenum foil, and the cutout portions have interior edges that are staggered to prevent an overlay of two or more interior edges. a plurality of composite material layers; a plurality of surface treated molybdenum foil layers interweaved between the composite material layers, wherein the molybdenum foil layer is surface treated via one or more surface treatments selected from the group comprising sol gel surface treatment, water based sol gel paint, grit blasting, sanding, sandblasting, solvent wiping, abrading, chemical cleaning, laser ablation, and chemical etching; and a plurality of adhesive layers disposed between and bonding adjacent layers of the composite material layers and the molybdenum foil layers; and wherein two or more of the composite material layers each have a cutout portion of surface treated molybdenum foil, and the cutout portions have interior edges that are staggered to prevent an overlay of two or more interior edges.
A composition comprising a population of microspheres each of which has a polymer matrix and, jointly incorporated into the matrix, a first and a second pharmaceutically active compound, wherein the polymer is a water insoluble water-swellable polymer which is anionically charged, wherein the first active is cationically charged, and the second active is electrostatically neutral and wherein one of the actives is a cytotoxic compound and the other active has activity complementary to the cytotoxic compound in tumour treatment.
A method of repairing a dielectric film, the method comprising the steps of: Introducing the dielectric film into a chamber; Introducing into the chamber a repair agent having a formula R 3 SiL, wherein each R is independently selected from the group consisting of H, methyl, and ethyl; L is a nitrogen-containing ring selected from the group consisting of pyrolidine and pyrazole; and one nitrogen in the nitrogen-containing ring is bonded directly to the Si atom; and Contacting the repair agent and the dielectric film; wherein the repair agent has a total concentration of metal contaminants of less than 10 ppmw. Introducing the dielectric film into a chamber; Introducing into the chamber a repair agent having a formula R 3 SiL, wherein each R is independently selected from the group consisting of H, methyl, and ethyl; L is a nitrogen-containing ring selected from the group consisting of pyrolidine and pyrazole; and one nitrogen in the nitrogen-containing ring is bonded directly to the Si atom; and Contacting the repair agent and the dielectric film;
A valve system, wherein the valve system is configured to determine at least one force applied to a portion of the valve system, the valve system comprising: at least one component comprising at least one conductive material, wherein the at least one component comprises a shaft having a first gear and the valve system further comprises a second gear engaged with the first gear of the shaft; characterized by a biasing element biasing the shaft in a first position, wherein the valve system is configured to determine an output torque applied to the valve stem based at least partially on the position of the at least a portion of the conductive material and a stiffness of the biasing element; and at least one inductance-to-digital converter sensor separated from the at least one conductive material of the at least one component, the inductance-to-digital converter sensor comprising an inductor and configured to wirelessly sense a position of at least a portion of the conductive material, the valve system configured to determine the at least one force applied to a portion of the valve system based at least partially on the position of the at least a portion of the conductive material sensed with the at least one inductance-to-digital converter sensor. at least one component comprising at least one conductive material, wherein the at least one component comprises a shaft having a first gear and the valve system further comprises a second gear engaged with the first gear of the shaft; characterized by a biasing element biasing the shaft in a first position, wherein the valve system is configured to determine an output torque applied to the valve stem based at least partially on the position of the at least a portion of the conductive material and a stiffness of the biasing element; and at least one inductance-to-digital converter sensor separated from the at least one conductive material of the at least one component, the inductance-to-digital converter sensor comprising an inductor and configured to wirelessly sense a position of at least a portion of the conductive material, the valve system configured to determine the at least one force applied to a portion of the valve system based at least partially on the position of the at least a portion of the conductive material sensed with the at least one inductance-to-digital converter sensor.