A compound of formula or a pharmaceutically acceptable salt, hydrate, or solvate thereof: wherein, R 1 is hydrogen or (CR a R a') m R b, R a and R a' being each independently hydrogen; C 1~ C 8 alkyl; C 2~ C 8 alkenyl; halogen; nitro; hydroxy; cyano; azido; amino; phenyl; benzyl; C 1~ C 8 alkoxy; C 1~ C 6 alkylamino; or substituted C 1~ C 6 alkyl, phenyl or benzyl having one or more R c groups; and R b being hydrogen; hydroxy; or substituted C 1~ C 6 alkyl, phenyl or benzyl having one or more R c groups; in which R c is halogen; cyano; nitro; azido; phenyl; benzyl; C(=O)R d; C(=O)OR d;C(=O)NR d R d; OR d; OC(=O)R e; OC(=O)OR e; OC(=O)NR d R d;OC 1~ C 6 alkylOR d; OC 1 ~C 6 alkylNR d R d; SR d; S(=O)R e; S(=O) 2 R e; S(=O) 2 NR d R d; CR d =NR d; NR d R d; NR d C(=O)R e; NR d C(=O)OR e; NR d C(=O)NR d R d; NR d C(=NR d)NR d R d; NR d S(=O) 2 R e; NR d OR d; NR d C 1 ~C 6 alkylNR d R d; or NR d C 1 ~C 6 alkylOR d; in which R d is hydrogen or R e; R e being phenyl; benzyl; C 1 -C 6 alkyl; or substituted phenyl, benzyl or C 1- C 6 alkyl having one or more hydroxy, halogen, C 1~ C 4 alkyl, C 1~ C 3 haloalkyl, C 1~ C4 alkoxy, amino, C 1~ C 4 alkylamino or di(C 1~ C 4 alkyl)amino groups; and m is 0, 1, or 2; R 2 is (CH 2)pU in which p is 0, 1, or 2; and U is morpholinyl, or R 14, R 15 and R 16 are independently hydrogen; C 1~ C 8 alkyl; cycloalkyl; C 2~ C 6 alkenyl; C 1~ C 6 alkoxy; C 1~ C 6 haloalkyl; C 1~ C 6 haloalkoxy; halogen; nitro; hydroxy; C 1~ C 6 hydroxyalkyl; cyano; sulfanyl; urea; amino; carboxyl; substituted amino, or carboxyl having one or two C 1~ C 3 alkyl groups; or any two of R 14, R 15 and R 16 being fused together to form a saturated or unsaturated heteromonocyclic or heterobicyclic ring; R 3 and R 3' are independently hydrogen; C 1~ C 10 alkyl; C 2~ C 10 alkenyl; C 2~ C 10 alkynyl; C 3~ C 10 cycloalkyl; C 8~ C 14 bicycloalkyl; C 3~ C 10 cycloalkenyl; C 8~ C 14 bicycloalkenyl; C 3~ C 7 heterocycloalkyl; C 7~ C 10 heterobicycloalkyl; C 1~ C 6 hydroxyalkyl; C 1~ C 8 alkoxy; C 1~ C 6 haloalkyl; C 1~ C 6 haloalkoxy; halogen; nitro; hydroxy; cyano; azido; amino; substituted C 1~ C 6 hydroxyalkyl, C 1~ C 10 alkyl, C 2~ C 10 alkenyl, C 2~ C 10 alkynyl, C 3~ C 10 cycloalkyl, C 8~ C 14 bicycloalkyl, C 3~ C 10 cycloalkenyl, C 8~ C 14 bicycloalkenyl, C 3~ C 7 heterocycloalkyl or C 7~ C 10 heterobicycloalkyl having one or more R f substituents; phenyl; naphtyl; benzyl; C 5~ C 10 heteroaryl; or substituted phenyl, naphtyl, benzyl or C 5~ C 10 heteroaryl having one or more R f substituents; wherein Q 1 is N or CR 4; Q 2 is N or CR 5; Q 3 is N or CR 6; Q 4 is N or CR 7; R 4, R 5, R 6, and R 7 are independently hydrogen; C 1~ C 10 alkyl; C 2~ C 10 alkenyl; C 2~ C 10 alkynyl; C 3~ C 10 cycloalkyl; C 8~ C 14 bicycloalkyl; C 3~ C 10 cycloalkenyl; C 8~ C 14 bicycloalkenyl; C 3~ C 7 heterocycloalkyl; C 7~ C 10 heterobicycloalkyl; C 1~ C 8 alkoxy; C 1~ C 6 haloalkyl; C 1~ C 6 haloalkoxy; halogen; nitro; hydroxy; cyano; azido; amino; substituted C 3~ C 10 alkyl, C 2~ C 10 alkenyl, C 2~ C 10 alkynyl, C 3~ C 10 cycloalkyl, C 8~ C 14 bicycloalkyl, C 3~ C 10 cycloalkenyl, C 8~ C 14 bicycloalkenyl, C 3~ C 7 heterocycloalkyl or C 7~ C 10 heterobicycloalkyl having one or more R h groups; phenyl; naphtyl; benzyl; C 5~ C 10 heteroaryl; substituted phenyl, naphtyl, benzyl or C 5~ C 10 heteroaryl having one or more R h substituents; C(=O)R i; C(=O)OR i; C(=O)NR i R i; OR i; OC(=O)R j; OC(=O)OR j; OC(=O)NR i R i; OC 1~ C 6 alkylOR i; OC 1~ C 6 alkylNR i R i; SR i, S(=O)R j; S(=O) 2 R j; S(=O) 2 NR i R i; CR i =NR i; NR i R i; NR i C(=O)R j; NR i C(=O)OR j; NR i C(=O)NR i R i; NR i C(=NR i)NR i R i; NR i S(=O) 2 R j; NR i OR i; NR i C 1~ C 6 alkylNR i R i; or NR i C 1~ C 6 alkylOR i; or any two of R 4, R 5, R 6 and R 7 are fused together to form a saturated, partially saturated or unsaturated 5-, 6- or 7-membered heteromonocyclic ring or a saturated, partially saturated, or unsaturated 6-, 7-, 8-, 9-, 10- or 11-membered heterobicyclic ring which has one to four nitrogen, oxygen or sulfur groups; in which R f and R h are each independently C 1 -C 6 alkyl; C 2~ C 6 alkenyl; C 2~ C 6 alkynyl; C 3~ C 8 cycloalkyl; C 5~ C 8 cycloalkenyl; C 3~ C 5 heterocycloalkyl; C 1~ C 6 haloalkyl; C 1~ C 6 haloalkoxy; halogen; azido; nitro; cyano; phenyl; benzyl; C(=O)R i; C(=O)OR i, C(=O)NR i R i; OR i; OC(=O)R j; OC(=O)OR j; OC(=O)NR i R i; OC 1~ C 6 alkylOR i; OC 1~ C 6 alkylNR i R i; SR i; S(=O)R j; S(=O) 2 R j; S(=O) 2 NR i R i; CR i =NR i; NR i R i; NR i C(=O)R j; NR i C(=O)OR j; NR d C(=O)NR i R i; NR i C(=NR i)NR i R i; NR i S(=O) 2 R j; NR i OR i; NRC 1~ C 6 alkylNR i R i; or NR i C 1~ C 6 alkylOR i; and R i is hydrogen or R j; R j being phenyl; benzyl; C 1 -C 6 alkyl; C 2~ C 6 alkenyl; C 2 -C 6 alkynyl; C 3~ C 8 cycloalkyl; C 5~ C 8 cycloalkenyl; C 3~ C 5 heterocycloalkyl; or substituted phenyl, benzyl or C 1~ C 6 alkyl having one or more hydroxy, halogen, C 1~ C 4 alkyl, C 1~ C 3 haloalkyl, C 1~ C 4 alkoxy, amino, C 1~ C 4 alkylamino or di(C 1~ C 4 alkyl)amino groups.