A compound, or a stereoisomer or pharmaceutically acceptable salt thereof, having the structure of Formula: wherein, X is O or CH 2; R 6 is chosen from optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C 6 -C 10 aryl-SO 2 -, optionally substituted heteroaryl-S-, or -N(R 1)(R 2), wherein R 1 is hydrogen or optionally substituted alkyl, and R 2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO-, optionally substituted heteroaryl-CO-, optionally substituted cycloalkyl-CO-, or optionally substituted alkyl-CO-; and each R 5, R 7 and R 8 is independently chosen from hydrogen, halogen, -OH, -CN, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 3 -C 7 carbocyclyl, optionally substituted C 3 -C 7 carbocyclyloxy, optionally substituted C 4 -C 12 carbocyclylalkyl, optionally substituted C 4 -C 12 carbocyclylalkoxy, optionally substituted C 1 -C 6 alkynyl, optionally substituted C 1 -C 6 alkenyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 aryloxy, optionally substituted C 6 -C 10 aryl-S-, optionally substituted C 7 -C 14 aralkoxy, optionally substituted heteroaryl, and optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C 6 -C 10 aryl-SO 2 -, optionally substituted heteroaryl-S-, or-N(R 1)(R 2), wherein R 1 is hydrogen or optionally substituted alkyl, and R 2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO-, optionally substituted heteroaryl-CO-, optionally substituted cycloalkyl-CO-, or optionally substituted alkyl-CO-; with the provision that at least one of R 5, R 7 and R 8 is hydrogen. X is O or CH 2; R 6 is chosen from optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C 6 -C 10 aryl-SO 2 -, optionally substituted heteroaryl-S-, or -N(R 1)(R 2), wherein R 1 is hydrogen or optionally substituted alkyl, and R 2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO-, optionally substituted heteroaryl-CO-, optionally substituted cycloalkyl-CO-, or optionally substituted alkyl-CO-; and each R 5, R 7 and R 8 is independently chosen from hydrogen, halogen, -OH, -CN, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 3 -C 7 carbocyclyl, optionally substituted C 3 -C 7 carbocyclyloxy, optionally substituted C 4 -C 12 carbocyclylalkyl, optionally substituted C 4 -C 12 carbocyclylalkoxy, optionally substituted C 1 -C 6 alkynyl, optionally substituted C 1 -C 6 alkenyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 aryloxy, optionally substituted C 6 -C 10 aryl-S-, optionally substituted C 7 -C 14 aralkoxy, optionally substituted heteroaryl, and optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C 6 -C 10 aryl-SO 2 -, optionally substituted heteroaryl-S-, or-N(R 1)(R 2), wherein R 1 is hydrogen or optionally substituted alkyl, and R 2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO-, optionally substituted heteroaryl-CO-, optionally substituted cycloalkyl-CO-, or optionally substituted alkyl-CO-; with the provision that at least one of R 5, R 7 and R 8 is hydrogen.