A compound represented by: and pharmaceutically acceptable salts and stereoisomers thereof, wherein: R 22 is selected independently for each occurrence from the group consisting of H and F; pp is 0, 1, 2 or 3; R 31 is selected from the group consisting of hydrogen, halogen, and C 1-4 alkyl; L 1 is selected from the group consisting of C 1 alkylene-C 4 cycloalkylene, C 4 cycloalkylene, and C 4 cycloalkylene-C 1 alkylene-, wherein L 1 may be optionally substituted by one, two or three substituents selected from the group consisting of halogen, hydroxyl, and C 1-3 alkyl (optionally substituted by one, two or three substituents each selected independently from R ff); R 44 is selected from the group consisting of C 1-3 alkyl, -C -OR', 4 to 6 membered heterocycloalkyl, a 5-6 membered monocyclic heteroaryl, and a 9-10 membered bicyclic heteroaryl, wherein the heteroaryl has one, two or three heteroatoms each selected from O, N, and S; and wherein the heteroaryl or heterocycloalkyl may be optionally substituted by one or two substituents each selected independently from R gg; R ff is selected for each occurrence from group consisting of halogen, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, oxo, -NR'R", -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl, where w is 0, 1, or 2, wherein C 1-4 alkyl, C 1-4 alkoxy, and C 2-4 alkenyl may be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, -NR'R", - NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl; R gg is selected for each occurrence from group consisting of halogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 3-6 cycloalkyl, -O-C - C 1-6 alkyl, - C -O- C 1-6 alkyl, -C -O- phenyl, -O-C -phenyl, phenyl, 4 to 6 membered heterocycloalkyl, -NR'R", oxo, -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1 - 3 alkyl, where w is 0, 1, or 2, wherein C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 3-6 cycloalkyl, phenyl and heterocycloalkyl may each be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkoxy, hydroxyl, C OH, -C OC 1-6 alkyl, -O-C C 1-6 alkyl, O-C -phenyl, -C O-NR'-C 1-6 alkyl,-O-C 3-6 cycloalkyl, -O-heterocycle, phenyl, -O-heteroaryl, -O-phenyl, -NR'R", -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl, where w is 0, 1, or 2; and R' and R" are each independently selected for each occurrence from H and C 1-4 alkyl or taken together with the nitrogen to which they are attached form a heterocyclic ring. R 22 is selected independently for each occurrence from the group consisting of H and F; pp is 0, 1, 2 or 3; R 31 is selected from the group consisting of hydrogen, halogen, and C 1-4 alkyl; L 1 is selected from the group consisting of C 1 alkylene-C 4 cycloalkylene, C 4 cycloalkylene, and C 4 cycloalkylene-C 1 alkylene-, wherein L 1 may be optionally substituted by one, two or three substituents selected from the group consisting of halogen, hydroxyl, and C 1-3 alkyl (optionally substituted by one, two or three substituents each selected independently from R ff); R 44 is selected from the group consisting of C 1-3 alkyl, -C -OR', 4 to 6 membered heterocycloalkyl, a 5-6 membered monocyclic heteroaryl, and a 9-10 membered bicyclic heteroaryl, wherein the heteroaryl has one, two or three heteroatoms each selected from O, N, and S; and wherein the heteroaryl or heterocycloalkyl may be optionally substituted by one or two substituents each selected independently from R gg; R ff is selected for each occurrence from group consisting of halogen, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, oxo, -NR'R", -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl, where w is 0, 1, or 2, wherein C 1-4 alkyl, C 1-4 alkoxy, and C 2-4 alkenyl may be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, -NR'R", - NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl; R gg is selected for each occurrence from group consisting of halogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 3-6 cycloalkyl, -O-C - C 1-6 alkyl, - C -O- C 1-6 alkyl, -C -O- phenyl, -O-C -phenyl, phenyl, 4 to 6 membered heterocycloalkyl, -NR'R", oxo, -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1 - 3 alkyl, where w is 0, 1, or 2, wherein C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 3-6 cycloalkyl, phenyl and heterocycloalkyl may each be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkoxy, hydroxyl, C OH, -C OC 1-6 alkyl, -O-C C 1-6 alkyl, O-C -phenyl, -C O-NR'-C 1-6 alkyl,-O-C 3-6 cycloalkyl, -O-heterocycle, phenyl, -O-heteroaryl, -O-phenyl, -NR'R", -NR'-S w -C 1-3 alkyl, S w -NR'R", and -S w -C 1-3 alkyl, where w is 0, 1, or 2; and R' and R" are each independently selected for each occurrence from H and C 1-4 alkyl or taken together with the nitrogen to which they are attached form a heterocyclic ring.