An adjustable scanning acoustic microscope sample fixture, comprising: a frame comprising a first end, a second end, a first side, and a second side; a first horizontal bar disposed on the first end of the frame; a first support member, movably coupled to the first horizontal bar, including a first face having a first groove structurally configured for engagement with a first end of a sample; a first side bar disposed on the first side of the frame; a first side wall, disposed on the first side of the frame, supporting the first side bar and structurally configured to attach to an immersion tank of a scanning acoustic microscope; a second horizontal bar disposed on the second end of the frame, the second horizontal bar comprising a second face opposing the first face of the first horizontal bar, the second face comprising a second groove structurally configured for engagement with a second end of the sample, the second horizontal bar engaged with the frame to be movable between the first end and the second end of the frame; a second side bar disposed on the second side of the frame; a second side wall, disposed on the second side of the frame, supporting the second side bar and structurally configured to attach to the immersion tank of the scanning acoustic microscope; and a first engagement mechanism releasably coupling a first end of the second horizontal bar to the first side bar; wherein the second horizontal bar is slidable along the first and second side bars, wherein the second groove opposes the first groove, and wherein the sample is securable on at least two edges by the first and second grooves such that an underside of the sample is unobstructed thereby allowing for through transmission inspection of a plurality of types of samples. a frame comprising a first end, a second end, a first side, and a second side; a first horizontal bar disposed on the first end of the frame; a first support member, movably coupled to the first horizontal bar, including a first face having a first groove structurally configured for engagement with a first end of a sample; a first side bar disposed on the first side of the frame; a first side wall, disposed on the first side of the frame, supporting the first side bar and structurally configured to attach to an immersion tank of a scanning acoustic microscope; a second horizontal bar disposed on the second end of the frame, the second horizontal bar comprising a second face opposing the first face of the first horizontal bar, the second face comprising a second groove structurally configured for engagement with a second end of the sample, the second horizontal bar engaged with the frame to be movable between the first end and the second end of the frame; a second side bar disposed on the second side of the frame; a second side wall, disposed on the second side of the frame, supporting the second side bar and structurally configured to attach to the immersion tank of the scanning acoustic microscope; and a first engagement mechanism releasably coupling a first end of the second horizontal bar to the first side bar; wherein the second horizontal bar is slidable along the first and second side bars, wherein the second groove opposes the first groove, and wherein the sample is securable on at least two edges by the first and second grooves such that an underside of the sample is unobstructed thereby allowing for through transmission inspection of a plurality of types of samples.