A multi-cavity blister package including a plurality of individual sealed recessed product cavities for packaging of product units in individual product cavities, in a sealed environment, and having a pull tab configuration for opening each individual product cavity, comprising: a thermoformed plastic base substrate formed of a non-PVC polymer material, the base substrate having a plurality of individual thermoformed recessed product cavities wherein each product cavity is configured to retain product therein and has an associated sealing surface area surrounding the product cavity, the base substrate having, for each individual product cavity, an associated notched line and including alternating severed and unsevered line portions (17S, 17U), the severed line portions extending completely through the thickness of the base substrate while the unsevered line portions maintain at least some uncut thickness of the base substrate intact, the notched line having been formed either sequentially or simultaneously with the thermoforming of the recessed product cavity in the mold; a peelable cover layer removably attached to the upper surface of the base substrate for sealing the plurality of individual product cavities, wherein each sealing surface area is disposed and configured to be removably attached to a lower surface of the peelable cover layer so as to enclose product in each sealed individual product cavity in a sealed environment; the attached cover layer and base substrate forming a multi-cavity blister package having a plurality of separable sections defined by section lines cut through a thickness direction of the cover layer and base substrate, each section including at least one notched line and associated product cavity and wherein the notched line extends across a portion of the sealing surface area of the associated product cavity, is spaced apart from the associated product cavity, and extends between two points on a perimeter of the section, the perimeter of the section being defined by one or more outer edges of the base substrate and the section lines, or by the surrounding section lines if the section does not border an outer edge of the base substrate, such that the notched line separates a corner or other edge portion (18, 18") of the section from a remaining portion of the section, and wherein the corner or other edge portion (18, 18") of each section of the base substrate is configured to be bent and broken off by a user at the notched line to form a pull tab that includes the broken off portion (18, 18") of the base substrate and the cover layer sealed thereto, enabling a user grasping the pull tab to peel back and separate the cover layer from the sealing surface area surrounding the individual associated product cavity of the section to open the sealed environment and enable release of the product from the associated product cavity. a thermoformed plastic base substrate formed of a non-PVC polymer material, the base substrate having a plurality of individual thermoformed recessed product cavities wherein each product cavity is configured to retain product therein and has an associated sealing surface area surrounding the product cavity, the base substrate having, for each individual product cavity, an associated notched line and including alternating severed and unsevered line portions (17S, 17U), the severed line portions extending completely through the thickness of the base substrate while the unsevered line portions maintain at least some uncut thickness of the base substrate intact, the notched line having been formed either sequentially or simultaneously with the thermoforming of the recessed product cavity in the mold; a peelable cover layer removably attached to the upper surface of the base substrate for sealing the plurality of individual product cavities, wherein each sealing surface area is disposed and configured to be removably attached to a lower surface of the peelable cover layer so as to enclose product in each sealed individual product cavity in a sealed environment; the attached cover layer and base substrate forming a multi-cavity blister package having a plurality of separable sections defined by section lines cut through a thickness direction of the cover layer and base substrate, each section including at least one notched line and associated product cavity and wherein the notched line extends across a portion of the sealing surface area of the associated product cavity, is spaced apart from the associated product cavity, and extends between two points on a perimeter of the section, the perimeter of the section being defined by one or more outer edges of the base substrate and the section lines, or by the surrounding section lines if the section does not border an outer edge of the base substrate, such that the notched line separates a corner or other edge portion (18, 18") of the section from a remaining portion of the section, and wherein the corner or other edge portion (18, 18") of each section of the base substrate is configured to be bent and broken off by a user at the notched line to form a pull tab that includes the broken off portion (18, 18") of the base substrate and the cover layer sealed thereto, enabling a user grasping the pull tab to peel back and separate the cover layer from the sealing surface area surrounding the individual associated product cavity of the section to open the sealed environment and enable release of the product from the associated product cavity.