Endoscopic instrument comprising a manipulating piece having a manipulating element, an instrument shaft having a section to be manipulated by a user, wherein the instrument shaft 16) is coupled to the manipulating piece, a positioning element having a first rotational axis, a pulling element which is mechanically coupled to the positioning element and the section of the instrument shaft, such that a rotational displacement of the positioning element may achieve an actuation of the section by transmitting a force via the pulling element, an actuator coupled to the positioning element, such that an actuation of the actuator may provide for a displacement of the positioning element by transmitting a force from the actuator to the positioning element, wherein the actuator comprises a second rotational axis, wherein the manipulating element is configured such that a user may displace the positioning element by actuating the manipulating element, wherein the manipulating element is mechanically coupled to the positioning element such that a force exerted by the user onto the manipulating element may at least be partially transferred onto the positioning element and may provide for a displacement of the positioning element, and wherein die first rotational axis and the second rotational axis are arranged at an angle of less than 90° relative to one another, characterized in that the manipulating element comprises a handle and an engaging element, the engaging element being arranged on a shaft, the handle being arranged along the shaft of the engaging element or concentrically along a virtual extension of this shaft, the handle and the engaging element being arranged such that they can be rotationally displaced relatively to one another, and the handle and the engaging element are coupled with one another such that a rotational displacement of the handle may result in a rotational displacement of the engaging element, and the engaging element being coupled to the positioning element, and wherein the manipulating element comprises a coupling arrangement having a first part and a second part, wherein one of the parts (48, 50) is connected to the handle and the other part (50, 48) is connected to the engaging element, wherein the parts (48, 50) are configured and arranged such that a transmission of a force between the handle and the engaging element may be effected when the handle is rotationally displaced, wherein the first part comprises two elements (48', 48") and the second part is embodied as a projection being arranged between the two elements (48', 48"), and the first and the second parts (48, 50) are arranged relative to one another such that a rotational displacement of the first part may result in a rotational displacement of the second part. a manipulating piece having a manipulating element, an instrument shaft having a section to be manipulated by a user, wherein the instrument shaft 16) is coupled to the manipulating piece, a positioning element having a first rotational axis, a pulling element which is mechanically coupled to the positioning element and the section of the instrument shaft, such that a rotational displacement of the positioning element may achieve an actuation of the section by transmitting a force via the pulling element, an actuator coupled to the positioning element, such that an actuation of the actuator may provide for a displacement of the positioning element by transmitting a force from the actuator to the positioning element, wherein the actuator comprises a second rotational axis, wherein the manipulating element is configured such that a user may displace the positioning element by actuating the manipulating element, wherein the manipulating element is mechanically coupled to the positioning element such that a force exerted by the user onto the manipulating element may at least be partially transferred onto the positioning element and may provide for a displacement of the positioning element, and wherein die first rotational axis and the second rotational axis are arranged at an angle of less than 90° relative to one another, characterized in that the manipulating element comprises a handle and an engaging element, the engaging element being arranged on a shaft, the handle being arranged along the shaft of the engaging element or concentrically along a virtual extension of this shaft, the handle and the engaging element being arranged such that they can be rotationally displaced relatively to one another, and the handle and the engaging element are coupled with one another such that a rotational displacement of the handle may result in a rotational displacement of the engaging element, and the engaging element being coupled to the positioning element, and wherein the manipulating element comprises a coupling arrangement having a first part and a second part, wherein one of the parts (48, 50) is connected to the handle and the other part (50, 48) is connected to the engaging element, wherein the parts (48, 50) are configured and arranged such that a transmission of a force between the handle and the engaging element may be effected when the handle is rotationally displaced, wherein the first part comprises two elements (48', 48") and the second part is embodied as a projection being arranged between the two elements (48', 48"), and the first and the second parts (48, 50) are arranged relative to one another such that a rotational displacement of the first part may result in a rotational displacement of the second part.