mhurhangee/ep-ind-claims huggingface dataset:
Swimming pool cleaning apparatus comprising: - a body, - at least one hydraulic circuit for circulating liquid between at least one liquid inlet and at least one liquid outlet, and through a filtration device of the cleaning apparatus, - a fluid circulation pump installed in the hydraulic circuit downstream of the filtration device, characterized in that the Swimming pool cleaning apparatus comprise: - means for adjusting the pressure in the hydraulic circuit upstream of the circulation pump, in response to a detected variation of this pressure, the said means for adjusting the pressure comprise: - at least a secondary liquid inlet connected to the hydraulic circuit, upstream of the circulation pump, the said at least a secondary liquid inlet being equipped with a valve mounted rotatably about an axis of rotation, and with means for moving the valve from an opened position to a closed position, the said means for moving the valve comprising a float of which the orientation and/or the force is a function of the orientation of the cleaning apparatus relative to a horizontal plane. - a body, - at least one hydraulic circuit for circulating liquid between at least one liquid inlet and at least one liquid outlet, and through a filtration device of the cleaning apparatus, - a fluid circulation pump installed in the hydraulic circuit downstream of the filtration device, characterized in that the Swimming pool cleaning apparatus comprise: - means for adjusting the pressure in the hydraulic circuit upstream of the circulation pump, in response to a detected variation of this pressure, the said means for adjusting the pressure comprise: - at least a secondary liquid inlet connected to the hydraulic circuit, upstream of the circulation pump, the said at least a secondary liquid inlet being equipped with a valve mounted rotatably about an axis of rotation, and with means for moving the valve from an opened position to a closed position, the said means for moving the valve comprising a float of which the orientation and/or the force is a function of the orientation of the cleaning apparatus relative to a horizontal plane.
Process for preparing 4-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridyl)-5- methoxypyridine-2-carboxamide, in base or hydrate form or in the form of pharmaceutically acceptable salts, of formula 1 below: characterized in that it comprises: • a step a): coupling reaction of compound 2 with 3,5-dichloroaminopyridine N-oxide (compound 3) according to the scheme below: And in that the condition for the amidation step a) is: - the use of the cyclic trimer of n-propylphosphonic anhydride (T3P). • a step a): coupling reaction of compound 2 with 3,5-dichloroaminopyridine N-oxide (compound 3) according to the scheme below: And in that the condition for the amidation step a) is: - the use of the cyclic trimer of n-propylphosphonic anhydride (T3P). - the use of the cyclic trimer of n-propylphosphonic anhydride (T3P).
Locking device for locking and transport of at least two mounted plate-shaped elements, which can be moved along a first direction and an opposing second direction, comprising - a first locking and/or transport element, which can be fastened on the first plate-shaped element (12 1), and - a second locking and/or transport element, which can be fastened on the second plate-shaped element (12 2), which can be moved between a transport position and a locking position, wherein the first and the second locking and/or transport element (11, 13) are designed and cooperate in such a manner that, if the second locking and/or transport element is in the locking position, the plate-shaped elements can be moved together along the first direction and the second direction, and if the second locking and/or transport element is in the transport position, a movement of the second plate-shaped element (12 2) into the second direction causes a transport of the first plate-shaped element (12 1) into the second direction, while a movement of the second plate-shaped element (12 2) into the first direction does not cause a transport of the first plate-shaped element (12 1) into the first direction, the first locking and/or transport element being designed as a closing member which can be fastened on the first plate-shaped element (12 1) having a recess, and the second locking and/or transport element being designed as a closing element, which can be fastened on the second plate-shaped element (12 2), which can be moved between the transport position and the locking position and has a locking member, characterized in that the recess of the closing member has a first section, which is opened into the first direction and closed into the second direction and a second section, which is completely or almost completely closed into the first direction and into the second direction, and the locking member of the closing element in the transport position can be brought into the first section and in the locking position engages into the second section, if the locking device is in the installed condition. - a first locking and/or transport element, which can be fastened on the first plate-shaped element (12 1), and - a second locking and/or transport element, which can be fastened on the second plate-shaped element (12 2), which can be moved between a transport position and a locking position,
A method of coating a steel or steel alloy material consisting of ferrite, martensite or bainite as a first microstructure at a reduced bath temperature, comprising: providing a steel or steel alloy material; simultaneously quenching and coating the steel or steel alloy material in a zinc-based alloy bath with a zinc-based alloy coating including a zinc-based alloy material and at least one dopant to form a coated steel or steel alloy material, wherein a liquidus temperature of the zinc-based alloy coating in the zinc-based alloy bath is between 275°C and 365°C, and wherein the zinc-based alloy bath has an operating temperature that is between 0°C and 50°C higher than the liquidus temperature; and altering said first microstructure of the ferrite, martensite or bainite in the steel or steel alloy material to form an alternative microstructure by a change in at least one of martensite tempering, bainite austempering, or a lack of carbon aging when coating the steel or steel alloy material with the zinc-based coating. providing a steel or steel alloy material; simultaneously quenching and coating the steel or steel alloy material in a zinc-based alloy bath with a zinc-based alloy coating including a zinc-based alloy material and at least one dopant to form a coated steel or steel alloy material, wherein a liquidus temperature of the zinc-based alloy coating in the zinc-based alloy bath is between 275°C and 365°C, and wherein the zinc-based alloy bath has an operating temperature that is between 0°C and 50°C higher than the liquidus temperature; and altering said first microstructure of the ferrite, martensite or bainite in the steel or steel alloy material to form an alternative microstructure by a change in at least one of martensite tempering, bainite austempering, or a lack of carbon aging when coating the steel or steel alloy material with the zinc-based coating.
A medical apparatus for administering a continuous flow or intermittent bolus of an anesthetic agent to facilitate a continuous or a prolonged nerve block, comprising: a catheter (202, 2202) having a catheter hub, a proximal end, a distal end, a lateral port arranged at a location proximal to the distal end, and at least one lumen extending from the proximal end to the distal end; a stimulating cannula (204, 2204) having a cannula hub, a proximal end, a distal end and a lumen extending from the proximal end of the cannula to the distal end of the cannula, the cannula configured to be arranged in the at least one lumen of the catheter such that a distal end portion of the cannula extends past the distal end of the catheter, wherein the distal end of the cannula is open and configured to provide a pharmacological agent to a nerve, wherein the catheter hub is provided on a proximal portion of the catheter; and an insert being arranged proximal to the catheter hub of the catheter and abuting and engaging between the proximal cannula end and the catheter hub; the cannula being adapted to slide into the catheter, through the catheter hub and through the center of the insert; wherein the insert is configured, for access and connection of a nerve stimulation device to the exposed segment of the cannula thereby allowing for the cannula to become a stimulatable needle, wherein the insert contains openings, which allow the cannula to fit through the insert, and an opening which provides access to the cannula through the insert; wherein the catheter and the cannula (204, 2204) are configured to be inserted into a patient simultaneously, the cannula having a tip including at least one of a sharp tip, a short bevelled tip, and a Touhy tip configured to puncture skin of a patient upon insertion, and wherein the catheter is configured to remain in the patient when the stimulating cannula is removed from the catheter.
A chimeric antigen receptor system comprising; (i) a receptor component comprising an antigen binding domain, a transmembrane domain and a first binding domain; and (ii) an intracellular signalling component comprising a signalling domain and a second binding domain which specifically binds the first binding domain of the receptor component; wherein binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain, whereas in the presence of the agent the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain, wherein the first binding domain comprises Tet Repressor Protein (TetR) and the second binding domain comprises Transcription inducing peptide (TiP); or wherein the first binding domain comprises TiP and the second binding domain comprises TetR; and the agent is tetracycline, doxycycline or minocycline or an analogue thereof. (i) a receptor component comprising an antigen binding domain, a transmembrane domain and a first binding domain; and (ii) an intracellular signalling component comprising a signalling domain and a second binding domain which specifically binds the first binding domain of the receptor component;
An implant system comprising - implantable material in at least partially uncured form, contained in a closed casing, under vacuum and sterilised, - a closed bag containing the casing, characterised in that - the casing consists of two parts, an inner transparent vacuum part and an outer non-transparent protecting part, - at least 5 % of the surface of the casing comprises sheet-like material having a thickness of 0.05 - 5 mm and having an original form, - the sheet-like material being selected from the group consisting of metallic materials, polymers, bioceramic materials and composites thereof, - provided that the material, once deformed from its original form to a changed form, is capable of maintaining that changed form unless subjected to external forces, such that the possible deformation is less than 5 % during 60 minutes while the external force does not exceed the force of gravity, and in that - the inner surface of the casing is treated with a coating selected from the group consisting of coating obtained by sol-gel process, bioactive glass particles, fibronectin, vitronection, fibrogen, polysaccharide, Arg-Gly-Asp peptide and laminin, hydroxyapatite, therapeutically active agents or particles releasing therapeutically active agents, cells and mixtures thereof, so as to provide a chemically active surface to the finished implant. - implantable material in at least partially uncured form, contained in a closed casing, under vacuum and sterilised, - a closed bag containing the casing, - the casing consists of two parts, an inner transparent vacuum part and an outer non-transparent protecting part, - at least 5 % of the surface of the casing comprises sheet-like material having a thickness of 0.05 - 5 mm and having an original form, - the sheet-like material being selected from the group consisting of metallic materials, polymers, bioceramic materials and composites thereof, - provided that the material, once deformed from its original form to a changed form, is capable of maintaining that changed form unless subjected to external forces, such that the possible deformation is less than 5 % during 60 minutes while the external force does not exceed the force of gravity, and in that - the inner surface of the casing is treated with a coating selected from the group consisting of coating obtained by sol-gel process, bioactive glass particles, fibronectin, vitronection, fibrogen, polysaccharide, Arg-Gly-Asp peptide and laminin, hydroxyapatite, therapeutically active agents or particles releasing therapeutically active agents, cells and mixtures thereof, so as to provide a chemically active surface to the finished implant.
A method for producing a metal-plated stainless steel material, the method comprising: performing an acid treatment of treating a stainless steel material covered with an oxide film including a naturally-generated passivation film with an acidic solution; wherein the acid treatment includes treating the stainless steel material with the acidic solution thereby forming an oxide film, wherein the oxide film has a lower density than that of the passivation film existing on the surface of the stainless steel material before the treatment with the acidic solution; performing an etching treatment of the stainless steel material after the acid treatment with an etching treatment agent; wherein the etching treatment is performed to reduce the thickness of the oxide film formed by the acid treatment to such an extent that the base iron of the stainless steel material is not exposed; and modifying a surface of the stainless steel material into a state suitable for a metal plating process by immersing the stainless steel material in a sulfuric acid aqueous solution after the etching, wherein the state suitable for the metal plating process is a state in which the molar ratio of Cr/O is within a range of 0.05 to 0.2 and the molar ratio of Cr/Fe is within a range of 0.5 to 0.8, wherein the molar ratio of Cr/O and the molar ratio of Cr/Fe are measured by a scanning-type Auger electron spectroscopy analysis for a surface of the oxide film; and performing a metal plating for the stainless steel material after the modifying to form a metal plating layer by electroless plating. performing an acid treatment of treating a stainless steel material covered with an oxide film including a naturally-generated passivation film with an acidic solution; wherein the acid treatment includes treating the stainless steel material with the acidic solution thereby forming an oxide film, wherein the oxide film has a lower density than that of the passivation film existing on the surface of the stainless steel material before the treatment with the acidic solution; performing an etching treatment of the stainless steel material after the acid treatment with an etching treatment agent; wherein the etching treatment is performed to reduce the thickness of the oxide film formed by the acid treatment to such an extent that the base iron of the stainless steel material is not exposed; and modifying a surface of the stainless steel material into a state suitable for a metal plating process by immersing the stainless steel material in a sulfuric acid aqueous solution after the etching, wherein the state suitable for the metal plating process is a state in which the molar ratio of Cr/O is within a range of 0.05 to 0.2 and the molar ratio of Cr/Fe is within a range of 0.5 to 0.8, wherein the molar ratio of Cr/O and the molar ratio of Cr/Fe are measured by a scanning-type Auger electron spectroscopy analysis for a surface of the oxide film; and performing a metal plating for the stainless steel material after the modifying to form a metal plating layer by electroless plating.
A seafloor mining system comprising: a vertical riser supported by a buoyancy device having variable buoyancy; a mining machine to deliver seafloor ore to the vertical riser; a lifting system to pass the ore through the vertical riser; a transport vessel removably connected to the vertical riser to receive ore from the vertical riser; characterized in that: the vertical riser is releasably anchored to the seafloor by an anchor separate from the mining machine; the vertical riser is in the form of a rigid pipe, attached to the transport vessel via a flexible link hose, wherein said link hose is supported by one or more hose buoys and is releasably connected to the transport vessel; and the buoyancy device having variable buoyancy is suitable for reducing tension on a chain between the vertical riser and the anchor to allow disconnection of the vertical riser and chain from the anchor. a vertical riser supported by a buoyancy device having variable buoyancy; a mining machine to deliver seafloor ore to the vertical riser; a lifting system to pass the ore through the vertical riser; a transport vessel removably connected to the vertical riser to receive ore from the vertical riser; characterized in that: the vertical riser is releasably anchored to the seafloor by an anchor separate from the mining machine; the vertical riser is in the form of a rigid pipe, attached to the transport vessel via a flexible link hose, wherein said link hose is supported by one or more hose buoys and is releasably connected to the transport vessel; and the buoyancy device having variable buoyancy is suitable for reducing tension on a chain between the vertical riser and the anchor to allow disconnection of the vertical riser and chain from the anchor. the vertical riser is releasably anchored to the seafloor by an anchor separate from the mining machine; the vertical riser is in the form of a rigid pipe, attached to the transport vessel via a flexible link hose, wherein said link hose is supported by one or more hose buoys and is releasably connected to the transport vessel; and the buoyancy device having variable buoyancy is suitable for reducing tension on a chain between the vertical riser and the anchor to allow disconnection of the vertical riser and chain from the anchor.
A tip assembly for delivering an AIOL into a patient's eye, the tip assembly comprising: an injector tip configured to receive the AIOL, the injector tip including a proximal portion and a distal portion configured to be inserted at least partially into the patient's eye, wherein the injector tip has a tapered shape such that the proximal portion is wider than the distal portion; a plunger assembly positionable at least partially within the injector tip, the plunger assembly being movable between a first configuration and a second configuration to push the AIOL distally out of the injector tip and into the patient's eye, wherein the plunger assembly includes: a plunger tip comprising a widened end portion shaped to engage the AIOL and an elongated body portion coupled to the widened end portion, and a frame structure coupled to the plunger tip in a telescoping arrangement such that: (a) when the plunger assembly is in the first configuration, the plunger tip is positioned at least partially within the frame structure so that the plunger tip and frame structure both engage the AIOL, and (b) when the plunger assembly is in the second configuration, the plunger tip is positioned distally relative to the frame structure so that the plunger tip engages the AIOL without the frame structure. an injector tip configured to receive the AIOL, the injector tip including a proximal portion and a distal portion configured to be inserted at least partially into the patient's eye, wherein the injector tip has a tapered shape such that the proximal portion is wider than the distal portion; a plunger assembly positionable at least partially within the injector tip, the plunger assembly being movable between a first configuration and a second configuration to push the AIOL distally out of the injector tip and into the patient's eye, wherein the plunger assembly includes: a plunger tip comprising a widened end portion shaped to engage the AIOL and an elongated body portion coupled to the widened end portion, and a frame structure coupled to the plunger tip in a telescoping arrangement such that: (a) when the plunger assembly is in the first configuration, the plunger tip is positioned at least partially within the frame structure so that the plunger tip and frame structure both engage the AIOL, and (b) when the plunger assembly is in the second configuration, the plunger tip is positioned distally relative to the frame structure so that the plunger tip engages the AIOL without the frame structure. a widened end portion shaped to engage the AIOL and an elongated body portion coupled to the widened end portion, and (a) when the plunger assembly is in the first configuration, the plunger tip is positioned at least partially within the frame structure so that the plunger tip and frame structure both engage the AIOL, and (b) when the plunger assembly is in the second configuration, the plunger tip is positioned distally relative to the frame structure so that the plunger tip engages the AIOL without the frame structure.
A rotational coupling device (10 or 110 or 210), comprising: a rotor configured for coupling to a shaft (12 or 112) for rotation therewith and disposed about a rotational axis, said rotor defining a first clutch engagement surface; a field shell disposed about said rotational axis and fixed against rotation; an electrical conductor disposed within said field shell on a first side of said rotor; an armature disposed on a second side of said rotor opposite said conductor, said armature defining a second clutch engagement surface, said armature, said rotor, and said field shell comprising members of a magnetic circuit; a torque transmission member (34 or 234) coupled to said armature for rotation therewith, said torque transmission member (34 or 234) disposed about said axis and supported by a bearing disposed about said axis; and, a sleeve (36 or 136) disposed about said axis radially inwardly of said bearing characterized in that said sleeve (36 or 136) has a magnetic permeability that is lower than a magnetic permeability of said members of said magnetic circuit. a rotor configured for coupling to a shaft (12 or 112) for rotation therewith and disposed about a rotational axis, said rotor defining a first clutch engagement surface; a field shell disposed about said rotational axis and fixed against rotation; an electrical conductor disposed within said field shell on a first side of said rotor; an armature disposed on a second side of said rotor opposite said conductor, said armature defining a second clutch engagement surface, said armature, said rotor, and said field shell comprising members of a magnetic circuit; a torque transmission member (34 or 234) coupled to said armature for rotation therewith, said torque transmission member (34 or 234) disposed about said axis and supported by a bearing disposed about said axis; and, a sleeve (36 or 136) disposed about said axis radially inwardly of said bearing characterized in that said sleeve (36 or 136) has a magnetic permeability that is lower than a magnetic permeability of said members of said magnetic circuit.