A composition comprising: an agent that binds to a member of the TNF receptor superfamily (TNFRSF), wherein the agent that binds to a member of the TNFRSF is an agonist that binds to a member of the TNFRSF selected from the group comprising 4-1BB and GITR; and a compound with a formula of: wherein: X is selected from the group consisting of H, halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, and 3 to 10-membered heterocycle, wherein the -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, or -C 3 -C 7 cycloalkyl; Y is selected from the group consisting of H, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, and 3 to 10-membered heterocycle wherein the -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: -halo, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, 3 to 10-membered heterocycle, aryl, OH, - CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, or nitroso; R' or R" is -H or -C 1 -C 6 alkyl; Z is -NHOH; and Q is selected from the group consisting of H and halo; or a pharmaceutically acceptable salt or solvate thereof. an agent that binds to a member of the TNF receptor superfamily (TNFRSF), wherein the agent that binds to a member of the TNFRSF is an agonist that binds to a member of the TNFRSF selected from the group comprising 4-1BB and GITR; and a compound with a formula of: wherein: X is selected from the group consisting of H, halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, and 3 to 10-membered heterocycle, wherein the -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, or -C 3 -C 7 cycloalkyl; Y is selected from the group consisting of H, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, and 3 to 10-membered heterocycle wherein the -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: -halo, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, 3 to 10-membered heterocycle, aryl, OH, - CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, or nitroso; R' or R" is -H or -C 1 -C 6 alkyl; Z is -NHOH; and Q is selected from the group consisting of H and halo; or a pharmaceutically acceptable salt or solvate thereof. X is selected from the group consisting of H, halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, and 3 to 10-membered heterocycle, wherein the -C 1 -C 6 alkyl, aryl, -C 3 -C 7 cycloalkyl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, -C 1 -C 6 alkyl, aryl, or -C 3 -C 7 cycloalkyl; Y is selected from the group consisting of H, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, and 3 to 10-membered heterocycle wherein the -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, aryl, or 3 to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: -halo, -C 1 -C 6 alkyl, -C 3 -C 12 cycloalkyl, 3 to 10-membered heterocycle, aryl, OH, - CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, or nitroso; R' or R" is -H or -C 1 -C 6 alkyl; Z is -NHOH; and Q is selected from the group consisting of H and halo; or a pharmaceutically acceptable salt or solvate thereof.