A compound of Formula: wherein R 1 is C 1-8 alkyl, halo-C 1-8 alkyl, C 3-8 cycloalkyl optionally substituted with the same or different 1 to 3 substituents selected from Group A 1, or C 3-8 cycloalkyl-C 1-4 alkyl wherein the C 3-8 cycloalkyl moiety may be optionally substituted with the same or different 1 to 3 substituents selected from Group A 1, Group A 1 is halogen, C 1-4 alkyl, and halo-C 1-4 alkyl, X 1 is a bond, or -O-, R 2 is hydrogen, or halogen, R 3 is hydrogen, or -Y 3 -COO-R 30, Y 3 is C 1-8 alkylene, C 3-8 cycloalkylene, bridged C 5-8 cycloalkylene, or C 6-14 arylene, R 30 is hydrogen, or C 1-4 alkyl, X 2 is =C(R 4)-, or =N-, R 4 is hydrogen, or C 1-4 alkyl, X 3 is -C(R 5)(R 6)-, X 4 is a bond, or -C(R 7)(R 8)-, X 5 is -C(R 9)(R 10)-, -N(R 11)-, or -O-, R 5 and R 6 are each independently hydrogen, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, R 7, R 8, R 9, and R 10 are each independently hydrogen, halogen, cyano, hydroxy, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, R 51, R 52, and R 53 are each independently hydrogen, C 1-4 alkyl, or C 6-14 aryl-C 1-4 alkyl, R 61, R 62, and R 63 are each independently C 1-4 alkyl, R 71, R 72, R 73, R 74, R 75, and R 76 are each independently hydrogen, or C 1-4 alkyl, R 11 is -CO-R 111, or -COO-R 112, R 111 is C 1-4 alkyl, R 112 is C 1-4 alkyl, or a pharmaceutically acceptable salt thereof. C 1-8 alkyl, halo-C 1-8 alkyl, C 3-8 cycloalkyl optionally substituted with the same or different 1 to 3 substituents selected from Group A 1, or C 3-8 cycloalkyl-C 1-4 alkyl wherein the C 3-8 cycloalkyl moiety may be optionally substituted with the same or different 1 to 3 substituents selected from Group A 1, Group A 1 is halogen, C 1-4 alkyl, and halo-C 1-4 alkyl, halogen, C 1-4 alkyl, and halo-C 1-4 alkyl, X 1 is a bond, or -O-, a bond, or -O-, R 2 is hydrogen, or halogen, hydrogen, or halogen, R 3 is hydrogen, or -Y 3 -COO-R 30, hydrogen, or -Y 3 -COO-R 30, Y 3 is C 1-8 alkylene, C 3-8 cycloalkylene, bridged C 5-8 cycloalkylene, or C 6-14 arylene, C 1-8 alkylene, C 3-8 cycloalkylene, bridged C 5-8 cycloalkylene, or C 6-14 arylene, R 30 is hydrogen, or C 1-4 alkyl, hydrogen, or C 1-4 alkyl, X 2 is =C(R 4)-, or =N-, =C(R 4)-, or =N-, R 4 is hydrogen, or C 1-4 alkyl, hydrogen, or C 1-4 alkyl, X 3 is -C(R 5)(R 6)-, -C(R 5)(R 6)-, X 4 is a bond, or -C(R 7)(R 8)-, a bond, or -C(R 7)(R 8)-, X 5 is -C(R 9)(R 10)-, -N(R 11)-, or -O-, -C(R 9)(R 10)-, -N(R 11)-, or -O-, R 5 and R 6 are each independently hydrogen, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, hydrogen, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, R 7, R 8, R 9, and R 10 are each independently hydrogen, halogen, cyano, hydroxy, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, hydrogen, halogen, cyano, hydroxy, C 1-4 alkyl, halo-C 1-4 alkyl, cyano-C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 alkyl substituted with one substituent selected from the group consisting of -O-R 51, -CO-R 61, -COO-R 52, -N(R 71)(R 72), -CO-N(R 73)(R 74), -N(R 75)-CO-R 62, -N(R 76)-COO-R 53, and -O-S 2 -R 63, R 51, R 52, and R 53 are each independently hydrogen, C 1-4 alkyl, or C 6-14 aryl-C 1-4 alkyl, hydrogen, C 1-4 alkyl, or C 6-14 aryl-C 1-4 alkyl, R 61, R 62, and R 63 are each independently C 1-4 alkyl, C 1-4 alkyl, R 71, R 72, R 73, R 74, R 75, and R 76 are each independently hydrogen, or C 1-4 alkyl, hydrogen, or C 1-4 alkyl, R 11 is -CO-R 111, or -COO-R 112, -CO-R 111, or -COO-R 112, R 111 is C 1-4 alkyl, C 1-4 alkyl, R 112 is C 1-4 alkyl, or a pharmaceutically acceptable salt thereof. C 1-4 alkyl, or a pharmaceutically acceptable salt thereof.