mhurhangee/ep-ind-claims huggingface dataset:
Norrin-based substance for use in a method of treating retinal edema in a retina of a human or animal subject by tightening inter-cellular junctions in endothelial or epithelial cells in vivo by means of administration of an effective amount of the norrin based substance by injection or eyedrops or pelletized solution droplets application to an eye containing the endothelial or epithelial cells, for selectively up - regulating a gene expression of cadherin and claudin-5 in the endothelial or epithelial cells and to tighten the inter cellular junctions of the tissue for prevention of vascular leakage or for repair of the vascular leakage to treat the edema in the retina, wherein the norrin based substance comprises an effective amount of, • an N-terminus norrin truncate that has a polypeptide N-terminus cleavage relative to a native norrin protein of up to 40 amino acid residues retaining a cysteine-knot motif of native norrin, wherein the polypeptide consists of SEQ ID. NO. 2, or of • a norrin mutant having at least about 85% amino acid identity with SEQ ID. NO. 1 and including amino acid substitutions relative to SEQ ID NO: 1 of R64E, T26A, S28A, S29A; P36A, R37A, R38A; or H127A, E129A, E130A; or combinations thereof. each capable of binding to frizzled-4 receptor of an endothelial or epithelial cell, said N-terminus norrin truncate or norrin mutant containing additional chemical moieties not normally part of the norrin molecule. • an N-terminus norrin truncate that has a polypeptide N-terminus cleavage relative to a native norrin protein of up to 40 amino acid residues retaining a cysteine-knot motif of native norrin, wherein the polypeptide consists of SEQ ID. NO. 2, or of • a norrin mutant having at least about 85% amino acid identity with SEQ ID. NO. 1 and including amino acid substitutions relative to SEQ ID NO: 1 of R64E, T26A, S28A, S29A; P36A, R37A, R38A; or H127A, E129A, E130A; or combinations thereof.
Parking lock arrangement for a motor vehicle transmission, having a blocking arrangement, which can be actuated between a release position and a blocking position, wherein the blocking arrangement is designed to immobilise a motor vehicle in the blocking position, and having an actuating arrangement for actuating the blocking arrangement, wherein the actuating arrangement has: - a housing, - a cam disc, which is supported on the housing and is driveable around an axis of rotation and which has an actuating cam portion that extends over a first circumferential region of the cam disc that is greater than 5° and less than 180°, and which cam disc has a second circumferential region, and - a lever, which is supported pivotably on the housing and is coupled to the blocking arrangement, wherein the lever is connected to a driving feature that is coupled to the cam disc, such that, when the cam disc is rotated, the driving feature is taken along by the actuating cam portion in such a way that the lever is pivoted in order to actuate the blocking arrangement, wherein the second circumferential region is configured in such a way that the lever can remain in a home position when the driving feature is in the second circumferential region, wherein the actuating cam portion is designed as a slotted link portion with a link slot, within which the driving feature is guided on two sides, thus allowing the lever to be pivoted positively in two directions, characterized in that the driving feature is arranged within the second circumferential region on an outer circumference of the cam disc, wherein the link slot is formed in the cam disc as a slot extending in the form of a chord of a circle. - a housing, - a cam disc, which is supported on the housing and is driveable around an axis of rotation and which has an actuating cam portion that extends over a first circumferential region of the cam disc that is greater than 5° and less than 180°, and which cam disc has a second circumferential region, and - a lever, which is supported pivotably on the housing and is coupled to the blocking arrangement, wherein the lever is connected to a driving feature that is coupled to the cam disc, such that, when the cam disc is rotated, the driving feature is taken along by the actuating cam portion in such a way that the lever is pivoted in order to actuate the blocking arrangement, wherein the second circumferential region is configured in such a way that the lever can remain in a home position when the driving feature is in the second circumferential region,
A cellobiohydrolase 1 variant comprising an amino acid sequence having a sequence identity of at least 80% with SEQ ID NO: 2 and comprising an amino acid substitution at position N209 corresponding to positions 1 to 526 of SEQ ID NO 2, wherein said substitution is N209D or N209E.
A gripping device for picking up and transporting a product, comprising a first and a second gripper arm (2, 3); a central clamp, which can be mounted onto a robot arm, wherein the clamp is arranged between the first and second gripper arms (2, 3), wherein the first gripper arm, the second gripper arm and the clamp each comprise an elastic belt, which lies against a surface section of the product when the product is picked up by the gripping device; and at least one spring element; wherein the corresponding elastic belt of the first gripper arm, the second gripper arm, and the clamp can be pressed against the surface section of the product by the corresponding spring element, in order to hold the product in the gripping device in a stationary manner during the transport, and wherein the product is held in a first direction by the elastic belts of the first and the second gripper arms (2, 3) and in a second direction, that is orthogonal to the first direction, by the elastic belt of the clamp. wherein the first gripper arm, the second gripper arm and the clamp each comprise an elastic belt, which lies against a surface section of the product when the product is picked up by the gripping device; and at least one spring element; wherein the corresponding elastic belt of the first gripper arm, the second gripper arm, and the clamp can be pressed against the surface section of the product by the corresponding spring element, in order to hold the product in the gripping device in a stationary manner during the transport, and wherein the product is held in a first direction by the elastic belts of the first and the second gripper arms (2, 3) and in a second direction, that is orthogonal to the first direction, by the elastic belt of the clamp.
A viscoelastic biostable foam comprising a triblock copolymer selected from the group consisting of and wherein m and p are each independently between 2 and 50 and n is between 2 and 20.
An immersion lithography apparatus comprising: an optical projection system having a last optical element, the optical projection system being configured to project an image onto a workpiece; a stage configured to support the workpiece adjacent the optical projection system when the image is being projected onto the workpiece; and a nozzle configured to provide immersion fluid to fill a gap between the last optical element and the workpiece, wherein the nozzle includes an inner cavity to retain the immersion fluid in the gap and an outer cavity to recover immersion fluid that exits the inner cavity, wherein the inner cavity defines a part of the gap between the last optical element and the workpiece, wherein the nozzle includes apertures disposed above the inner cavity for introducing fluid into and drawing fluid from the inner cavity, and wherein the apertures are disposed on opposite sides of the last optical element and are configured for introducing the fluid on one side of the last optical element and drawing the fluid on the other side of the last optical element. an optical projection system having a last optical element, the optical projection system being configured to project an image onto a workpiece; a stage configured to support the workpiece adjacent the optical projection system when the image is being projected onto the workpiece; and a nozzle configured to provide immersion fluid to fill a gap between the last optical element and the workpiece,
Insulating support for a ground-based electrical power supply track which is intended for a terrestrial transport system, in particular of the tramway type, in the form of a profile-member of insulating material which comprises a substantially planar upper face which is intended to receive the elements of the electrical power supply track and a planar lower face which is intended to be supported on the ground, the profile-member being provided with a longitudinal groove which is arranged in the upper face in order to receive a conductive track element, characterised in that the profile-member is provided with a web which connects the upper face to the lower face and through which at least one longitudinal supply conduit which is intended to receive an electrical power supply line of the high-voltage network extends, and there is only one longitudinal groove, and the longitudinal groove and each supply conduit are arranged centrally and symmetrically about a longitudinal centre plane of the support perpendicular relative to the upper face.
A local feature descriptor extracting apparatus (1Ato 1J) comprising: a feature point detecting unit configured to detect feature points in an image; a first local region acquiring unit configured to acquire a local region for each of the feature points; a first subregion dividing unit configured to divide each local region into a plurality of subregions; a first subregion feature vector generating unit configured to generate a gradient orientation histogram as a feature vector for each of the subregions in each local region; and a dimension selecting unit configured to select dimensions from the feature vector in each subregion such that at least one gradient orientation differs between proximate subregions and output elements of the selected dimensions as a feature descriptor of the local region. a feature point detecting unit configured to detect feature points in an image; a first local region acquiring unit configured to acquire a local region for each of the feature points; a first subregion dividing unit configured to divide each local region into a plurality of subregions; a first subregion feature vector generating unit configured to generate a gradient orientation histogram as a feature vector for each of the subregions in each local region; and a dimension selecting unit configured to select dimensions from the feature vector in each subregion such that at least one gradient orientation differs between proximate subregions and output elements of the selected dimensions as a feature descriptor of the local region.
A process for the preparation of a layer system comprising on a substrate (i) a Ni layer having a thickness ≤ 3.0 μm, (ii) a Ni-P layer having a thickness ≤ 1.0 μm, (iii) a Au layer ≤ 1.0 μm comprising the following steps: (i) electropolishing the surface of said substrate, (ii) plating a Ni layer onto the electropolished surface obtained in step (i) above such that the thickness of said Ni layer is ≤ 3.0 μm, (iii) plating a Ni-P layer onto the Ni layer obtained in step (ii) above such that the thickness of said Ni-P layer is ≤ 1.0 μm, (iv) plating an Au layer onto the Ni-P layer obtained in step (iii) above such that the thickness of said Au layer is ≤ 1.0 μm. (i) a Ni layer having a thickness ≤ 3.0 μm, (ii) a Ni-P layer having a thickness ≤ 1.0 μm, (iii) a Au layer ≤ 1.0 μm (i) electropolishing the surface of said substrate, (ii) plating a Ni layer onto the electropolished surface obtained in step (i) above such that the thickness of said Ni layer is ≤ 3.0 μm, (iii) plating a Ni-P layer onto the Ni layer obtained in step (ii) above such that the thickness of said Ni-P layer is ≤ 1.0 μm, (iv) plating an Au layer onto the Ni-P layer obtained in step (iii) above such that the thickness of said Au layer is ≤ 1.0 μm.
Oxidation stable oil formulation comprising a base oil composition, said base oil composition comprising at least 80% by weight of a mineral-derived naphthenic base oil or at least 80% by weight of a mineral-derived paraffinic base oil, a content of between 5 and 1000 mg/kg of a copper passivator selected from optionally substituted benzotriazole compounds represented by the formula wherein R4 may be hydrogen or a group represented by the formula or by the formula wherein: c is 0, 1, 2 or 3; R 3 is a straight or branched C 1-4 alkyl group; R 5 is a methylene or ethylene group; R 6 and R 7 are hydrogen or the same or different straight or branched alkyl groups of 1-18 carbon atoms, preferably a branched alkyl group of 1-12 carbon atoms; R 8 and R 9 are the same or different alkyl groups of 3-15 carbon atoms; from 0.001 wt% to less than 0.1 wt% of an anti-wear additive is selected from organic polysulfides represented by the formula R 1 - a-R 2 wherein: a is 2, 3, 4 or 5; R 1 and R 2 are independently selected from the group consisting of optionally substituted, straight or branched, saturated or unsaturated C 1 -C 25 hydrocarbon groups. c is 0, 1, 2 or 3; R 3 is a straight or branched C 1-4 alkyl group; R 5 is a methylene or ethylene group; R 6 and R 7 are hydrogen or the same or different straight or branched alkyl groups of 1-18 carbon atoms, preferably a branched alkyl group of 1-12 carbon atoms; R 8 and R 9 are the same or different alkyl groups of 3-15 carbon atoms; from 0.001 wt% to less than 0.1 wt% of an anti-wear additive is selected from organic polysulfides represented by the formula R 1 - a-R 2 wherein: a is 2, 3, 4 or 5; R 1 and R 2 are independently selected from the group consisting of optionally substituted, straight or branched, saturated or unsaturated C 1 -C 25 hydrocarbon groups. a is 2, 3, 4 or 5; R 1 and R 2 are independently selected from the group consisting of optionally substituted, straight or branched, saturated or unsaturated C 1 -C 25 hydrocarbon groups.
A computer-implemented method of stabilizing bounding boxes for objects in a video stream, the method comprising: receiving a video stream comprising a sequence of image frames; detecting an object in the image frames and generating a bounding box surrounding the object; measuring a noise level for the video stream; and temporally filtering the bounding box over a plurality of image frames based on the measured noise level, thereby stabilizing the bounding box in the video stream, wherein the bounding box is temporally filtered over a number of preceding image frames characterized in that the number of preceding image frames is adapted such that a higher noise level implies a temporal filtering over a greater number of preceding image frames and a lower noise level implies a temporal filtering over a smaller number of preceding image frames. receiving a video stream comprising a sequence of image frames; detecting an object in the image frames and generating a bounding box surrounding the object; measuring a noise level for the video stream; and temporally filtering the bounding box over a plurality of image frames based on the measured noise level, thereby stabilizing the bounding box in the video stream, wherein the bounding box is temporally filtered over a number of preceding image frames characterized in that the number of preceding image frames is adapted such that a higher noise level implies a temporal filtering over a greater number of preceding image frames and a lower noise level implies a temporal filtering over a smaller number of preceding image frames.
Fusion protein for expression of peptides on the bacterial surface, characterised in that it comprises a bacterial membrane-binding region and a fused exposed peptide where the bacterial membrane-binding region is a peptide which consists of the amino acid sequence SEQ ID NO: 1, and wherein the exposed peptide is fused to the N-terminal end of the amino acid sequence SEQ ID NO: 1.
A method of wireless communication performed by a user equipment, UE, comprising: determining a time division duplex, TDD, frame structure of a plurality of frames, wherein a plurality of uplink, UL, subframes of the plurality of frames, assigned by a base station, for transmitting a plurality of UL resources associated with a control signaling is a function of the TDD frame structure; determining a location of a UL resource, scheduled by the base station, within the TDD frame structure for communicating a type of the control signaling, the type of the control signaling including at least one of a random access channel, a uplink control channel, a sounding reference signal, SRS, or a scheduling request, SR;; determining if the location of the scheduled UL resource for communicating at least one type of the control signaling occurs on one of the plurality of UL subframes assigned for transmitting the scheduled UL resource; and communicating the at least one type of the control signaling using the scheduled UL resource over one of the plurality of UL subframes when the location of the scheduled UL resource for communicating the at least one type of the control signaling occurs on one of the plurality of UL subframes assigned for transmitting the scheduled UL resource. determining a time division duplex, TDD, frame structure of a plurality of frames, wherein a plurality of uplink, UL, subframes of the plurality of frames, assigned by a base station, for transmitting a plurality of UL resources associated with a control signaling is a function of the TDD frame structure; determining a location of a UL resource, scheduled by the base station, within the TDD frame structure for communicating a type of the control signaling, the type of the control signaling including at least one of a random access channel, a uplink control channel, a sounding reference signal, SRS, or a scheduling request, SR;; determining if the location of the scheduled UL resource for communicating at least one type of the control signaling occurs on one of the plurality of UL subframes assigned for transmitting the scheduled UL resource; and communicating the at least one type of the control signaling using the scheduled UL resource over one of the plurality of UL subframes when the location of the scheduled UL resource for communicating the at least one type of the control signaling occurs on one of the plurality of UL subframes assigned for transmitting the scheduled UL resource.
A method for making a signal composite for a cooling signal device for an absorbent article, the signal composite comprising a polymer skin layer and a first stimulation layer, the method comprising the steps of: coextruding the polymer skin layer and the first stimulation layer to form a film; wherein the first stimulation layer comprises a binder and a cooling agent, and wherein the cooling agent comprises 50 to 98 percent of the total weight of the signal composite, and wherein the polymer skin layer is 2 to 10 percent of the total weight of the signal composite. coextruding the polymer skin layer and the first stimulation layer to form a film; wherein the first stimulation layer comprises a binder and a cooling agent, and wherein the cooling agent comprises 50 to 98 percent of the total weight of the signal composite, and wherein the polymer skin layer is 2 to 10 percent of the total weight of the signal composite.
Method for operational tilt determination in vehicles, in particular in rail vehicles with at least one chassis as well as at least one vehicle body, wherein an angle coefficient is continuously ascertained at least from a first acceleration of the vehicle as well as from a second acceleration of the vehicle, wherein the ascertained angle coefficient is continuously compared with a nominal angle coefficient, and wherein data at least relating to the first acceleration and the second acceleration is then recorded if the first acceleration exceeds a defined acceleration threshold value, characterised in that the recorded data, as a function of occurrence locations and occurrence time points at least of the first acceleration and the second acceleration, are assigned at least to a first section, wherein at least a first average value of the first acceleration and one second average value of the second acceleration are formed for this at least first section.
A porous membrane for a secondary battery comprising non-electroconductive particles and a binder for a porous membrane, wherein the non-electroconductive particles are particles of a polymer obtained by polymerizing a polymerizable monomer composition comprising divinylbenzene and ethylvinylbenzene, an arithmetic mean value of a shape factor of the non-electroconductive particles is 1.05 to 1.60, as described in the description, a variation coefficient of the shape factor is 16% or less, a variation coefficient of a particle diameter of the non-electroconductive particles is 26% or less, and the binder for a porous membrane is a (meth)acrylic polymer.
A method of forming a build in a powder bed, comprising: emitting a plurality of laser beams from selected fibers of a diode laser fiber array onto the powder bed, the selected fibers of the array corresponding to a pattern of a layer of the build; and simultaneously melting powder in the powder bed corresponding to the pattern of the layer of the build; wherein the method further comprising: emitting laser beams from fibers at least adjacent to the pattern of the layer; and characterized by heating the powder adjacent to the powder of the layer of the build to control a cooling rate of the melted powder. emitting a plurality of laser beams from selected fibers of a diode laser fiber array onto the powder bed, the selected fibers of the array corresponding to a pattern of a layer of the build; and simultaneously melting powder in the powder bed corresponding to the pattern of the layer of the build; wherein the method further comprising: emitting laser beams from fibers at least adjacent to the pattern of the layer; and characterized by heating the powder adjacent to the powder of the layer of the build to control a cooling rate of the melted powder. emitting laser beams from fibers at least adjacent to the pattern of the layer; and characterized by heating the powder adjacent to the powder of the layer of the build to control a cooling rate of the melted powder.
A compound of Formula, a stereoisomer thereof, a radioisotope thereof, or a pharmaceutically acceptable salt thereof wherein Ar is a heteroaryl which may be optionally substituted with 1, 2, or 3 substituents where each substituent independently is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, -OH, -COOH, amino, nitro, C 2 -C 3 alkanoyl group, mono- or di- C 1 -C 3 alkylamino, or halogen; n is 1 or 2; m is 1 or 2; R 1 is H or halogen; R 2 is H, C 1 -C 3 alkoxy, or halogen; R 3 is H, halogen or C 1 -C 3 alkoxy; R 4 is H, -OH, or halogen; R 5 is H, -OH, or halogen; and --- is a single bond or a double bond, with the provisos a) and b) a) when R 1 is H then at least one of R 2 and R 3 is not H; and b) when one or both of R 2 and R 3 is H then R 1 is not H. Ar is a heteroaryl which may be optionally substituted with 1, 2, or 3 substituents where each substituent independently is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, -OH, -COOH, amino, nitro, C 2 -C 3 alkanoyl group, mono- or di- C 1 -C 3 alkylamino, or halogen; n is 1 or 2; m is 1 or 2; R 1 is H or halogen; R 2 is H, C 1 -C 3 alkoxy, or halogen; R 3 is H, halogen or C 1 -C 3 alkoxy; R 4 is H, -OH, or halogen; R 5 is H, -OH, or halogen; and --- is a single bond or a double bond, with the provisos a) and b) a) when R 1 is H then at least one of R 2 and R 3 is not H; and b) when one or both of R 2 and R 3 is H then R 1 is not H. a) when R 1 is H then at least one of R 2 and R 3 is not H; and b) when one or both of R 2 and R 3 is H then R 1 is not H.