mhurhangee/ep-ind-claims huggingface dataset:
An interfering ribonucleic acid (RNAi) agent for use in (i) the treatment of an atherosclerotic cardiovascular disease (ASCVD), an ASCVD risk equivalent, an elevated risk for cardiovascular disease, heterozygous familial hypercholesterolemia, or homozygous familial hypercholesterolemia, in a subject, or (ii) the prevention of a cardiovascular event, or the prevention of the development of an ASCVD, in a subject; wherein the RNAi agent is a double-stranded ribonucleic acid comprising a sense strand and an antisense strand that forms a double-stranded region, the antisense strand comprising the nucleotide sequence of SEQ ID NO: 3, and the sense strand comprising the nucleotide sequence of SEQ ID NO: 4, wherein SEQ ID NO: 3 is 5'-asCfsaAfAfAfgCfaAfaAfcAfgGfuCfuagsasa-3', in which a, g, c, and u are 2'-O-methyl (2'-OMe) A, G, C, and U, respectively; Af, Gf, Cf, and Uf are 2'-fluoro A, G, C, and U, respectively; and s is a phosphorothioate linkage, and SEQ ID NO: 4 is 5'-csusagacCfuGfudTuugcuuuugu-3', in which a, g, c, and u are 2'-O-methyl (2'-OMe) A, G, C, and U, respectively; Af, Gf, Cf, and Uf are 2'-fluoro A, G, C, and U, respectively; dT is 2'-deoxythymidine; and s is a phosphorothioate linkage, and wherein the double-stranded ribonucleic acid has a covalently attached triantennary GalNAc ligand; and wherein the RNAi agent is to be administered as a subcutaneous injection in a dosing regimen that comprises a loading phase followed by a maintenance phase, wherein the loading phase comprises administering the RNAi agent as at least two doses separated by a time interval, wherein the time interval is about 90 days. wherein the RNAi agent is a double-stranded ribonucleic acid comprising a sense strand and an antisense strand that forms a double-stranded region, the antisense strand comprising the nucleotide sequence of SEQ ID NO: 3, and the sense strand comprising the nucleotide sequence of SEQ ID NO: 4, wherein SEQ ID NO: 3 is 5'-asCfsaAfAfAfgCfaAfaAfcAfgGfuCfuagsasa-3', in which a, g, c, and u are 2'-O-methyl (2'-OMe) A, G, C, and U, respectively; Af, Gf, Cf, and Uf are 2'-fluoro A, G, C, and U, respectively; and s is a phosphorothioate linkage, and SEQ ID NO: 4 is 5'-csusagacCfuGfudTuugcuuuugu-3', in which a, g, c, and u are 2'-O-methyl (2'-OMe) A, G, C, and U, respectively; Af, Gf, Cf, and Uf are 2'-fluoro A, G, C, and U, respectively; dT is 2'-deoxythymidine; and s is a phosphorothioate linkage, and wherein the double-stranded ribonucleic acid has a covalently attached triantennary GalNAc ligand; and wherein the RNAi agent is to be administered as a subcutaneous injection in a dosing regimen that comprises a loading phase followed by a maintenance phase, wherein the loading phase comprises administering the RNAi agent as at least two doses separated by a time interval, wherein the time interval is about 90 days.
A communication device comprising: a communication unit configured to: determine whether a request for transmitting occurs on a basis of storing data in a transmission buffer; transmit, to another communication device, a BA start frame including both a block ACK, BA, request parameter for a data frame and a data payload constructed using one or more pieces of data acquired from the transmission buffer for a confirmation response, wherein the communication unit is configured to transmit the BA start frame on a basis of occurrence of the request for transmitting; and receive, from the another communication device, a second frame including a BA response parameter for the data frame and the confirmation response to the data payload, wherein the communication unit is further configured to execute transmission of the data frame based on the BA response parameter included in the received second frame. determine whether a request for transmitting occurs on a basis of storing data in a transmission buffer; transmit, to another communication device, a BA start frame including both a block ACK, BA, request parameter for a data frame and a data payload constructed using one or more pieces of data acquired from the transmission buffer for a confirmation response, wherein the communication unit is configured to transmit the BA start frame on a basis of occurrence of the request for transmitting; and receive, from the another communication device, a second frame including a BA response parameter for the data frame and the confirmation response to the data payload, wherein the communication unit is further configured to execute transmission of the data frame based on the BA response parameter included in the received second frame.
A connector for connecting power or control systems to infrastructure such as for example subsea infrastructure, said connector comprising a male component and a female component, the male and female components comprising cooperating mating surfaces (12,52) and means for locking the male and female components together (43, 53) to establish a physical connection between the components, the locking means being retractably mounted within one of the male or female components but extendible from that component into the other of the male or female components to lock the two components together against axial and rotational movement whilst providing a snag free release when the locking means is in the retracted position and further means to establish an electrical connection between the components, the arrangement being such that in use, the physical connection is made before the electrical connection when the male and female components are assembled and the electrical connection is broken before the physical connection is broken when the connector is disassembled, characterised in that the locking means comprises a lever pivotally mounted within the female component of the connector, wherein the lever is adapted for movement between a locked condition in which the lever extends through apertures in the mating surface of the female connecter and an unlocked condition in which the lever is retracted from the aperture.
A method for accessing services in a telecommunications network, the method comprising the steps of: - i. a User Equipment, UE, registering with a telecommunications network for a provision of a first service defined in a user subscription of a Home Subscriber Server, HSS, of the telecommunications network; - ii. sending out from the UE a request for a security token associated with an IP Television, IPTV, service associated with the user; - iii. receiving at the UE from the HSS a security token establishing a binding between the user's subscription to the first service and the user's IPTV subscription, wherein the security token is for use in accessing the IPTV service; and - iv. receiving at the UE a list of active IPTV Terminal Functions, ITFs, associated with the IPTV service along with ongoing programming information for each active ITF of the list. - i. a User Equipment, UE, registering with a telecommunications network for a provision of a first service defined in a user subscription of a Home Subscriber Server, HSS, of the telecommunications network; - ii. sending out from the UE a request for a security token associated with an IP Television, IPTV, service associated with the user; - iii. receiving at the UE from the HSS a security token establishing a binding between the user's subscription to the first service and the user's IPTV subscription, wherein the security token is for use in accessing the IPTV service; and - iv. receiving at the UE a list of active IPTV Terminal Functions, ITFs, associated with the IPTV service along with ongoing programming information for each active ITF of the list.
A method, comprising: initiating, based on a voice input, a first network communication session with a computing device; and transmitting, to the computing device, via the first network communication session, data indicative of the voice input; the method being characterized by further comprising: receiving, from the computing device, based on the data indicative of the voice input, an indication of a type of communication session from a plurality of types of communication sessions and information associated with the voice input; terminating, based on the indication of the type of communication session, the first network communication session; determining that at least a portion of the data indicative of the voice input is associated with at least a portion of the information; and causing, based on determining that at least the portion of the data indicative of the voice input is associated with at least the portion of the information, an output. initiating, based on a voice input, a first network communication session with a computing device; and transmitting, to the computing device, via the first network communication session, data indicative of the voice input; the method being characterized by further comprising: receiving, from the computing device, based on the data indicative of the voice input, an indication of a type of communication session from a plurality of types of communication sessions and information associated with the voice input; terminating, based on the indication of the type of communication session, the first network communication session; determining that at least a portion of the data indicative of the voice input is associated with at least a portion of the information; and causing, based on determining that at least the portion of the data indicative of the voice input is associated with at least the portion of the information, an output. receiving, from the computing device, based on the data indicative of the voice input, an indication of a type of communication session from a plurality of types of communication sessions and information associated with the voice input; terminating, based on the indication of the type of communication session, the first network communication session; determining that at least a portion of the data indicative of the voice input is associated with at least a portion of the information; and causing, based on determining that at least the portion of the data indicative of the voice input is associated with at least the portion of the information, an output.
An engine start control apparatus for a hybrid vehicle including a drivetrain including an engine (Eng), a motor, a normally-open hydraulic clutch disposed between the engine (Eng) and the motor, and arranged to be engaged by a clutch hydraulic pressure generated based on a discharge pressure from an oil pump (M-O/P) driven by the motor, the engine start control apparatus comprising: an engine start control section configured to crank the engine (Eng) by using the motor as a starter motor while the hydraulic clutch is slip-engaged when the discharge pressure from the oil pump(M-O/P) is ensured by driving the motor, when the engine (Eng) is started after an ignition switch is switched to an ON state, characterized in that the engine start control section being configured to drive the oil pump (M-O/P) by the motor at a no load during a predetermined time period after the engine (Eng) is stopped when the ignition switch is in an OFF state, wherein the engine start control section is configured to set the predetermined time period for the no-load driving of the oil pump (M-O/P), based on at least one of an accumulated running distance condition, an outside air temperature condition, a previous running distance condition, and a battery capacity condition, wherein the engine start control section is configured to set the predetermined time period for the no-load driving of the oil pump to a longer time period as an accumulated running distance is longer. an engine start control section configured to crank the engine (Eng) by using the motor as a starter motor while the hydraulic clutch is slip-engaged when the discharge pressure from the oil pump(M-O/P) is ensured by driving the motor, when the engine (Eng) is started after an ignition switch is switched to an ON state, characterized in that the engine start control section being configured to drive the oil pump (M-O/P) by the motor at a no load during a predetermined time period after the engine (Eng) is stopped when the ignition switch is in an OFF state, wherein the engine start control section is configured to set the predetermined time period for the no-load driving of the oil pump (M-O/P), based on at least one of an accumulated running distance condition, an outside air temperature condition, a previous running distance condition, and a battery capacity condition, wherein the engine start control section is configured to set the predetermined time period for the no-load driving of the oil pump to a longer time period as an accumulated running distance is longer.
An eddy current separation apparatus comprising; - a rotating magnetic circular plate having a plurality of permanent magnets with alternating polarity, the magnets arranged in a circumferential direction, - a palette arranged next to the rotating magnetic circular plate with a clearance, - an actuator section having a rotating shaft fixed with the rotating magnetic circular plate, - a feed section containing product to be separated and for supplying a predetermined quantity of the product to be separated to the palette, - a discharge section having two containers for recycling and for collecting the product to be separated supplied from the feed section to the palette into the containers for recycling, when the state of the containers for recycling is switched from a closed position to an open position, and - a control unit for controlling the rotating magnetic circular plate, the actuator section, the feed section and the discharge section; characterized in that the eddy current separation apparatus is adapted to perform: - a first step in which the feed section supplies a predetermined quantity of the product to be separated to the palette, - a second step in which the discharge section is switched to the open position from the closed position after the first step has been finished and a fixed time has passed, and - a third step in which the discharge section is switched to the closed position after the second step has been finished, further wherein the eddy current separation apparatus is adapted to perform from a first step to a third step again after the third step has been finished. - a rotating magnetic circular plate having a plurality of permanent magnets with alternating polarity, the magnets arranged in a circumferential direction, - a palette arranged next to the rotating magnetic circular plate with a clearance, - an actuator section having a rotating shaft fixed with the rotating magnetic circular plate, - a feed section containing product to be separated and for supplying a predetermined quantity of the product to be separated to the palette, - a discharge section having two containers for recycling and for collecting the product to be separated supplied from the feed section to the palette into the containers for recycling, when the state of the containers for recycling is switched from a closed position to an open position, and - a control unit for controlling the rotating magnetic circular plate, the actuator section, the feed section and the discharge section; characterized in that the eddy current separation apparatus is adapted to - a first step in which the feed section supplies a predetermined quantity of the product to be separated to the palette, - a second step in which the discharge section is switched to the open position from the closed position after the first step has been finished and a fixed time has passed, and - a third step in which the discharge section is switched to the closed position after the second step has been finished, further wherein the eddy current separation apparatus is adapted to perform from a first step to a third step again after the third step has been finished.
A smart key system for an automobile, comprising: an on-vehicle device configured to transmit and receive a radio signal to and from an electronic key; and a resin panel through which the on-vehicle device is fixed to and held by a body of the automobile, wherein the on-vehicle device comprises: a transmitter configured to transmit a search signal to the electronic key; a receiver configured to receive a response signal transmitted from the electronic key in response to the search signal; a control unit configured to control at least the transmission of the search signal; and a resin case configured to house therein the transmitter, the receiver, and the control unit, and wherein the smart key system is configured such that electrostatic charging generated by the search signal transmitted from the transmitter is removed from either or both of the resin case and the resin panel. a transmitter configured to transmit a search signal to the electronic key; a receiver configured to receive a response signal transmitted from the electronic key in response to the search signal; a control unit configured to control at least the transmission of the search signal; and a resin case configured to house therein the transmitter, the receiver, and the control unit, and wherein the smart key system is configured such that electrostatic charging generated by the search signal transmitted from the transmitter is removed from either or both of the resin case and the resin panel.
A cap ply reinforcement cord which is provided in the cap ply reinforcement layer that is located between the tread and the belt package in a pneumatic radial vehicle tire comprising the said tread and the said belt package, and that is formed by winding spirally as strip comprising at least two cords such that it will make 0 to 5° angle with the equatorial plane on the said belt package, and which is formed by twisting two aliphatic polyamide yarns together and characterized in that one of the said polyamide yarns has a linear density in range of 1300-1500 dtex, and the other one of the said polyamide yarns has the linear density in range of 850-1000 dtex wherein the difference between the pre-twisting level of the said yarns is at most 20%.
A device for reducing venous blood flow in a human limb, the device comprising: a first rigid part having a first non-linear inner profile; a second rigid part having a second inner profile generally facing the first inner profile; and a coupling portion that couples the first and second rigid parts together while allowing relative movement of the first and second rigid parts between a clamped position and an unclamped position; wherein the first and second inner profiles are arranged to press against veins in the limb when the device is in the clamped position and thereby reduce venous blood flow in the limb, wherein the device further comprises a cushioning element disposed on at least one of the first inner profile and the second inner profile, wherein the cushioning element extends over the first inner profile and the second inner profile; wherein the cushioning element is affixed to the first inner profile and is not affixed to the second inner profile, characterised in that the cushioning element is freely slidable with respect to the second rigid part along the second inner profile. a first rigid part having a first non-linear inner profile; a second rigid part having a second inner profile generally facing the first inner profile; and a coupling portion that couples the first and second rigid parts together while allowing relative movement of the first and second rigid parts between a clamped position and an unclamped position; wherein the first and second inner profiles are arranged to press against veins in the limb when the device is in the clamped position and thereby reduce venous blood flow in the limb, wherein the device further comprises a cushioning element disposed on at least one of the first inner profile and the second inner profile, wherein the cushioning element extends over the first inner profile and the second inner profile; wherein the cushioning element is affixed to the first inner profile and is not affixed to the second inner profile, characterised in that the cushioning element is freely slidable with respect to the second rigid part along the second inner profile.
A method for measuring positions of structures on a substrate comprising the steps of: • placing the substrate in a stage of a metrology machine, wherein the substrate carries a plurality of structures; • carrying out a first measurement loop (41 1) and at least one second measurement loop (41 2) according to a predefined recipe, wherein the first measurement loop (41 1) is started at a time where a substrate temperature is different from the temperature at the stage, and the at least one second measurement loop (41 2) is started at a time after the first measurement loop and when the substrate temperature is different from the temperature at the stage; • obtaining from the first and the at least one second measurement loops (41 1, 41 2) at least two distorted grids (51 1, 51 2) representing a two-dimensional distribution of the structures measured with the predetermined recipe; and • calculating a real grid from the at least two compensated grids (54 1), wherein each compensated grid is determined from each of the at least two distorted grids, and the real grid is similar to a measured grid where the temperature of the substrate matches the temperature of the stage within a predetermined threshold. • placing the substrate in a stage of a metrology machine, wherein the substrate carries a plurality of structures; • carrying out a first measurement loop (41 1) and at least one second measurement loop (41 2) according to a predefined recipe, wherein the first measurement loop (41 1) is started at a time where a substrate temperature is different from the temperature at the stage, and the at least one second measurement loop (41 2) is started at a time after the first measurement loop and when the substrate temperature is different from the temperature at the stage; • obtaining from the first and the at least one second measurement loops (41 1, 41 2) at least two distorted grids (51 1, 51 2) representing a two-dimensional distribution of the structures measured with the predetermined recipe; and • calculating a real grid from the at least two compensated grids (54 1), wherein each compensated grid is determined from each of the at least two distorted grids, and the real grid is similar to a measured grid where the temperature of the substrate matches the temperature of the stage within a predetermined threshold.