A device for receiving and then emptying, under pressure monitored by a laboratory for the preparation of pharmaceutical products, a biopharmaceutical fluid in large quantities, at least equal to about 10 l, with a view to subsequent treatment such as filtration, final formulation, filling of containers with smaller capacity, of the type comprising: ▪ a flexible and sealed internal bag made of plastic material, having an internal enclosure able and intended to receive a quantity at least equal to about 10 1 of biopharmaceutical fluid and provided with an orifice for filling with the biopharmaceutical fluid and with an orifice for emptying the biopharmaceutical fluid and, associated in a sealed manner with the filling orifice and with the emptying orifice, a filling tube having an inlet for filling the enclosure with the biopharmaceutical fluid, able to be associated with a line for filling the biopharmaceutical fluid, and an emptying tube having an outlet for emptying the enclosure from the biopharmaceutical fluid, able to be associated with a line for emptying the biopharmaceutical fluid, ▪ an external container in which the internal bag is placed, a compression chamber being arranged between the external container and the internal bag whose filling inlet and emptying outlet are located outside the external container, an orifice for injecting pressurized emptying gas in the compression chamber being provided on said external container, ▪ sealed crossing of the external container by the filling tube and the emptying tube, ▪ the deformation capacities respectively of the internal bag and of the external container being chosen so that, when the pressurized emptying gas is injected into the compression chamber, the internal bag is compressed and so that the biopharmaceutical fluid therein is emptied under pressure through the emptying outlet, characterized in that: ▪ the external container comprises a sealed external receptacle made of plastic material, forming an external enclosure in which the internal bag is placed, arranging the compression chamber, and including the orifice for injecting pressurized emptying gas, ▪ the filling tube and the emptying tube pass through the external receptacle by permanently fixed connections, the filling inlet and the emptying outlet being located outside the external receptacle, ▪ it also comprises an integrated means for purging the gas filling the filling line before filling with the biopharmaceutical fluid so that this gas does not enter the internal bag, ▪ the external receptacle and the internal bag form a single-use coherent whole. ▪ a flexible and sealed internal bag made of plastic material, having an internal enclosure able and intended to receive a quantity at least equal to about 10 1 of biopharmaceutical fluid and provided with an orifice for filling with the biopharmaceutical fluid and with an orifice for emptying the biopharmaceutical fluid and, associated in a sealed manner with the filling orifice and with the emptying orifice, a filling tube having an inlet for filling the enclosure with the biopharmaceutical fluid, able to be associated with a line for filling the biopharmaceutical fluid, and an emptying tube having an outlet for emptying the enclosure from the biopharmaceutical fluid, able to be associated with a line for emptying the biopharmaceutical fluid, ▪ an external container in which the internal bag is placed, a compression chamber being arranged between the external container and the internal bag whose filling inlet and emptying outlet are located outside the external container, an orifice for injecting pressurized emptying gas in the compression chamber being provided on said external container, ▪ sealed crossing of the external container by the filling tube and the emptying tube, ▪ the deformation capacities respectively of the internal bag and of the external container being chosen so that, when the pressurized emptying gas is injected into the compression chamber, the internal bag is compressed and so that the biopharmaceutical fluid therein is emptied under pressure through the emptying outlet, ▪ the external container comprises a sealed external receptacle made of plastic material, forming an external enclosure in which the internal bag is placed, arranging the compression chamber, and including the orifice for injecting pressurized emptying gas, ▪ the filling tube and the emptying tube pass through the external receptacle by permanently fixed connections, the filling inlet and the emptying outlet being located outside the external receptacle, ▪ it also comprises an integrated means for purging the gas filling the filling line before filling with the biopharmaceutical fluid so that this gas does not enter the internal bag, ▪ the external receptacle and the internal bag form a single-use coherent whole.