mhurhangee/ep-ind-claims huggingface dataset:
A method of producing a library of eukaryotic cell clones containing DNA encoding a diverse repertoire of binders that recognise targets, comprising providing donor DNA molecules encoding the binders, and eukaryotic cells, wherein the binders are antibodies, proteins or peptides, introducing the donor DNA into the cells and providing a site-specific nuclease within the cells, wherein the nuclease cleaves a recognition sequence in cellular DNA to create an integration site at which the donor DNA becomes integrated into the cellular DNA, integration occurring through DNA repair mechanisms endogenous to the cells, thereby creating recombinant cells containing donor DNA integrated in the cellular DNA, and culturing the recombinant cells to produce clones, thereby providing a library of eukaryotic cell clones containing donor DNA encoding the repertoire of binders.
Recombinant microorganism genetically modified for i) Synthesizing a lactic acid monomer by fermenting a carbon source; ii) Depolymerizing polylactic acid wherein said microorganism expresses at least one enzyme for depolymerizing PLA, selected from a proteinase K, a lipase and a PLA depolymerase and a lactate dehydrogenase for synthesizing lactic acid. i) Synthesizing a lactic acid monomer by fermenting a carbon source; ii) Depolymerizing polylactic acid
Contact apparatus of an electric switching device having at least one fixed contact and a rotary contact body having at least one contact arm which has a length and on at least one end of which a moving contact piece is arranged, said apparatus comprising supply and discharge conductors (20, 28) in a plurality of contact portions, • the current path in the contact apparatus forming a 360° winding which consists of a plurality of conductor portions (A1,... A5) and has an axis that is perpendicular to the plane in which the rotary contact body (23, 23') is movable, • a first conductor portion being a first conductor that leads to the at least one fixed contact, • a second conductor portion extending through contacts (22', 24') of the contact apparatus, • a third conductor portion extending above the rotary contact body (23, 23'), characterised in that a final conductor portion is a second conductor leading to the rotary contact body (23, 23'), which extends in parallel with and in close proximity to the first conductor and both conductors extend substantially in parallel with the rotary contact body (23, 23') when said body is in the closed position, and in that the first conductor and second conductor are both formed as straight and rigid busbars having a length corresponding at least to the length of the at least one contact arm of the rotary contact body. • the current path in the contact apparatus forming a 360° winding which consists of a plurality of conductor portions (A1,... A5) and has an axis that is perpendicular to the plane in which the rotary contact body (23, 23') is movable, • a first conductor portion being a first conductor that leads to the at least one fixed contact, • a second conductor portion extending through contacts (22', 24') of the contact apparatus, • a third conductor portion extending above the rotary contact body (23, 23'),
A transaction card, comprising: a first layer (12, 22, 32, 42, 58); and a discontinuous metal stratum (14, 24, 34, 44, 54), characterised in that the discontinuous metal stratum is disposed on a first surface (10, 20, 30, 40, 50) of the first layer (12, 22, 32, 42, 58) and comprises a plurality of isolated metal features (15, 25, 35) that form a halftone pattern; and in that the transaction card further comprises a contact, contactless, or dual interface transaction module (16, 26, 36, 46, 56) disposed in the first layer (12, 22, 32, 42, 58) and electrically isolated from the discontinuous metal stratum (14, 24, 34, 44, 54). a first layer (12, 22, 32, 42, 58); and a discontinuous metal stratum (14, 24, 34, 44, 54), characterised in that the discontinuous metal stratum is disposed on a first surface (10, 20, 30, 40, 50) of the first layer (12, 22, 32, 42, 58) and comprises a plurality of isolated metal features (15, 25, 35) that form a halftone pattern; and in that the transaction card further comprises a contact, contactless, or dual interface transaction module (16, 26, 36, 46, 56) disposed in the first layer (12, 22, 32, 42, 58) and electrically isolated from the discontinuous metal stratum (14, 24, 34, 44, 54).
Rotor pair for a compressor block of a screw machine, wherein the rotor pair is comprised of a secondary rotor that rotates about a first axis and a main rotor that rotates about a second axis, wherein the number of teeth (z 2) in the main rotor is 3 and the number of teeth (z 1) in the secondary rotor is 4, characterized in that the relative profile depth of the secondary rotor PT rel = rk 1 − rf 1 rk 1 is at least 0.5, preferably at least 0.515, and at most 0.65, preferably at most 0.595, wherein rk 1 is an addendum circle radius drawn around the outer circumference of the secondary rotor and rf 1 is a dedendum circle radius starting at the profile base of the secondary rotor, wherein the ratio of an axis distance α of of the first axis to the second axis and the addendum circle radius rk 1 a rk 1 is at least 1.636 and at most 1.8, preferably at most 1.733, wherein preferably the main rotor is configured with a wrap-around angle Φ HR for which it holds that 240° ≤ Φ HR ≤ 360°, and wherein it holds for a rotor length ratio L HR /α: 1.4 ≤ L HR / a ≤ 3.4, wherein the rotor length ratio is formed from the ratio of the rotor length L HR of the main rotor and the axis distance α, and the rotor length L HR of the main rotor is formed by a distance of a suction-side main-rotor rotor end face to an opposite pressure-side main-rotor rotor end face.
A method for testing a hydraulically-actuated device having a housing defining an interior volume and a piston disposed within the interior volume such that the piston divides the interior volume into a first chamber and a second chamber, where the piston is movable relative to the housing to a maximum first position in response to pressure within the second chamber being higher than pressure within the first chamber and to a maximum second position in response to pressure within the first chamber being higher than pressure within the second chamber, characterised by: moving the piston to the first position by varying pressure within at least one of the first chamber and the second chamber such that pressure within the second chamber is higher than pressure within the first chamber; and while the piston remains in the first position, varying pressure to reduce the force(s) acting on the piston; and measuring if the pressure within the first or second chamber meets a threshold or target pressure during a pre-determined period of time selected based on a calculated or approximated period of time necessary to detect a leak within the hydraulically-actuated device or a system associated therewith. moving the piston to the first position by varying pressure within at least one of the first chamber and the second chamber such that pressure within the second chamber is higher than pressure within the first chamber; and while the piston remains in the first position, varying pressure to reduce the force(s) acting on the piston; and measuring if the pressure within the first or second chamber meets a threshold or target pressure during a pre-determined period of time selected based on a calculated or approximated period of time necessary to detect a leak within the hydraulically-actuated device or a system associated therewith.
A recombinant adeno-associated virus (rAAV) particle, comprising: an rAAV vector, wherein the rAAV vector comprises a nucleic acid molecule, comprising (i) at least one AAV inverted terminal repeat and (ii) a non-AAV nucleotide sequence encoding a 21-hydroxylase protein, wherein the non-AAV nucleotide sequence is operably linked to a CAG promoter, and wherein the rAAV particle is an AAV5 serotype.
Method for drilling cavities in subterranean formations comprising a step of carrying away the drill cuttings using an aqueous fluid in the form of a foam, obtained by mixing: - an aqueous composition (C 1) comprising, for 100 % by weight: - from 0.5 % by weight to 25 % by weight of a compound of formula: R 1 -C -NH-CH(COOM)-(CH 2) n -COOM' wherein n represents an integer equal to 1 or 2, R 1 represents a saturated or unsaturated, linear or branched, aliphatic hydrocarbon radical comprising from 8 to 18 carbon atoms, M represents a monovalent cation and M', which is identical to or different from M, represents a hydrogen atom or a monovalent cation; or a mixture of compounds of formula, and - from 75 % to 99.5 % by weight of water, - with a gas or a mixture of gases, selected from air, nitrogen or carbon dioxide. - an aqueous composition (C 1) comprising, for 100 % by weight: - from 0.5 % by weight to 25 % by weight of a compound of formula: R 1 -C -NH-CH(COOM)-(CH 2) n -COOM' wherein n represents an integer equal to 1 or 2, R 1 represents a saturated or unsaturated, linear or branched, aliphatic hydrocarbon radical comprising from 8 to 18 carbon atoms, M represents a monovalent cation and M', which is identical to or different from M, represents a hydrogen atom or a monovalent cation; or a mixture of compounds of formula, and - from 75 % to 99.5 % by weight of water, - from 0.5 % by weight to 25 % by weight of a compound of formula: R 1 -C -NH-CH(COOM)-(CH 2) n -COOM' wherein n represents an integer equal to 1 or 2, R 1 represents a saturated or unsaturated, linear or branched, aliphatic hydrocarbon radical comprising from 8 to 18 carbon atoms, M represents a monovalent cation and M', which is identical to or different from M, represents a hydrogen atom or a monovalent cation; or a mixture of compounds of formula, and - from 75 % to 99.5 % by weight of water, - with a gas or a mixture of gases, selected from air, nitrogen or carbon dioxide.
A baby bottle warmer comprising a body positionable, when in use, on a level supporting surface such as a table, the body having a chamber to receive a baby bottle to be warmed, said chamber being configured such that a bottle received in the chamber is supported at an angle relative to the supporting surface on which the body is positioned, said chamber also comprising a base wall and a side wall, the baby bottle warmer also comprising a heater, characterised in that the heater is positioned at or adjacent to the base wall of the chamber such that heating of the baby bottle mixes the contents of the baby bottle.
A composition comprising a first material substituted with at least one group of formula and a second material substituted with at least one group selected from groups of formulae (IIa) and (IIb): wherein: Sp 1 represents a first spacer group; NB independently in each occurrence is a norbornene group that may be unsubstituted or substituted with one or more substituents; n1 is 0 or 1; ml is 1 if n1 is 0 and ml is at least 1 if n1 is 1; Sp 2 represents a second spacer group; n2 is 0 or 1; m2 is 1 if n2 is 0 and m2 is at least 1 if n2 is 1; Ar 1 independently in each occurrence represents an aryl or heteroaryl group that may be unsubstituted or substituted with one or more substituents; R 1 independently in each occurrence is H or a substituent; and * represents a point of attachment to the first or second material. Sp 1 represents a first spacer group; NB independently in each occurrence is a norbornene group that may be unsubstituted or substituted with one or more substituents; n1 is 0 or 1; ml is 1 if n1 is 0 and ml is at least 1 if n1 is 1; Sp 2 represents a second spacer group; n2 is 0 or 1; m2 is 1 if n2 is 0 and m2 is at least 1 if n2 is 1; Ar 1 independently in each occurrence represents an aryl or heteroaryl group that may be unsubstituted or substituted with one or more substituents; R 1 independently in each occurrence is H or a substituent; and * represents a point of attachment to the first or second material.
A method for generating turn-by-turn direction previews, comprising: receiving, using one or more computing devices, a request for a turn-by-turn direction preview; generating, using the one or more computing devices, a set of turn-by-turn directions based on a series of road segments connecting a first geographic location and a second geographic location, wherein each direction in the set of turn-by-turn directions is associated with a corresponding waypoint; identifying, using the one or more computing devices, a set of images corresponding to the series of road segments between two adjacent waypoints of the set of turn-by-turn directions; determining, using the one or more computing devices, a subset of the set of images to include in the turn-by-turn direction preview by filtering, using the one or more computing devices, the set of images to include only the images within a threshold distance from the waypoint corresponding to each turn-by-turn direction; and generating, using the one or more computing devices, the turn-by-turn direction preview including the determined subset of the set of images. receiving, using one or more computing devices, a request for a turn-by-turn direction preview; generating, using the one or more computing devices, a set of turn-by-turn directions based on a series of road segments connecting a first geographic location and a second geographic location, wherein each direction in the set of turn-by-turn directions is associated with a corresponding waypoint; identifying, using the one or more computing devices, a set of images corresponding to the series of road segments between two adjacent waypoints of the set of turn-by-turn directions; determining, using the one or more computing devices, a subset of the set of images to include in the turn-by-turn direction preview by filtering, using the one or more computing devices, the set of images to include only the images within a threshold distance from the waypoint corresponding to each turn-by-turn direction; and generating, using the one or more computing devices, the turn-by-turn direction preview including the determined subset of the set of images.
Computer program stored in a computer-readable storage medium, the computer program providing a method for generating a training dataset for identifying a dart pin location on a dart target through a dart pin location identification network model, when being executed in one or more processors of a computing device, the method comprising the steps of: obtaining a dart target photographing training image in which at least one dart pin hits in a bit of a segment of a plurality of segments included in the dart target, wherein each segment of said plurality of segments includes a predetermined number of bits; and assigning a label corresponding to the obtained dart target photographing training image; wherein the dart pin location identification network model is a neural network model trained by using the training dataset including the dart target photographing training image and the label, the label includes information about the location of the segment and the location of the bit on the segment hit by the dart pin, and the dart pin location identification neural network model processes input data to output hit location information including the location of the segment and the location of the bit on the segment hit by the dart pin. obtaining a dart target photographing training image in which at least one dart pin hits in a bit of a segment of a plurality of segments included in the dart target, wherein each segment of said plurality of segments includes a predetermined number of bits; and assigning a label corresponding to the obtained dart target photographing training image; wherein the dart pin location identification network model is a neural network model trained by using the training dataset including the dart target photographing training image and the label, the label includes information about the location of the segment and the location of the bit on the segment hit by the dart pin, and the dart pin location identification neural network model processes input data to output hit location information including the location of the segment and the location of the bit on the segment hit by the dart pin.
An aircraft passenger seat swivel assembly for an aircraft seating unit, comprising: (a) a pair of transversely spaced-apart base rails (32,34) each including fore and aft fittings for connecting the base rails to an aircraft deck and defining a horizontal plane extending between the pair of base rails; and characterized by (b) a swivel assembly located within the space defined between the pair of base rails and mounted between the pair of base rails to extend along the horizontal plane. (a) a pair of transversely spaced-apart base rails (32,34) each including fore and aft fittings for connecting the base rails to an aircraft deck and defining a horizontal plane extending between the pair of base rails; and characterized by (b) a swivel assembly located within the space defined between the pair of base rails and mounted between the pair of base rails to extend along the horizontal plane.
A skin penetration enhancer comprising a peptide, wherein the peptide comprises an amino acid sequence comprising ten consecutive amino acid residues as set forth in SEQ ID NO: 1, 2, 3, or 6; eleven consecutive amino acid residues as set forth in SEQ ID NO: 7 or 8; or twelve consecutive amino acid residues as set forth in SEQ ID NO: 4 or 5.
A lobe pump, reduction gears, motor combination comprising: a lobe pump having a pump housing, inlet, outlet, and a drive shaft and a lay shaft at least partially surrounded by the pump housing, said pump housing having a rear flange and an axis relative to a center of the pump housing extending parallel to the drive and lay shafts (46; 76), wherein said axis is non-colinear with either of the drive and lay shafts (46; 76); reduction gears operably coupled to the drive shaft of the lobe pump at an output shaft, said reduction gears also having an input shaft and a housing surrounding at least a portion of the output shaft and the input shaft, said housing of the reduction gears having a front flange connected to the rear flange of the lobe pump with the output shaft of the reduction gears nested relative to the drive shaft of the pump internal to at least one of the front flange, rear flange, housing of the reduction gears and the pump housing; and a motor connected by a driven shaft to the input shaft of the reduction gears; wherein the driven shaft is rotated at a higher speed than the output shaft of the reduction gears; characterised in that the front and rear flanges have a plurality of bores, and said drive shaft and said output shaft operably couple at at least two angular positions relative to one another with the bores of the front and rear flanges aligning at the at least two angular positions thereby orienting the outlet of the pump in at least two different directions. a lobe pump having a pump housing, inlet, outlet, and a drive shaft and a lay shaft at least partially surrounded by the pump housing, said pump housing having a rear flange and an axis relative to a center of the pump housing extending parallel to the drive and lay shafts (46; 76), wherein said axis is non-colinear with either of the drive and lay shafts (46; 76); reduction gears operably coupled to the drive shaft of the lobe pump at an output shaft, said reduction gears also having an input shaft and a housing surrounding at least a portion of the output shaft and the input shaft, said housing of the reduction gears having a front flange connected to the rear flange of the lobe pump with the output shaft of the reduction gears nested relative to the drive shaft of the pump internal to at least one of the front flange, rear flange, housing of the reduction gears and the pump housing; and a motor connected by a driven shaft to the input shaft of the reduction gears; wherein the driven shaft is rotated at a higher speed than the output shaft of the reduction gears;
An igniter tube with a central channel consisting of a combustible tube, made of a combustible material comprising a cellulose ester, on the inner face of which an ignition charge is deposited in the form of geometric patterns spaced apart along the length of said combustible tube, and adheres to said combustible tube, said ignition charge comprising 88 wt% to 92 wt% of ignition powder(s) and 7 wt% to 10 wt% of cellulose ester, said ignition powder being a powdered granular material comprising an inorganic oxidant compound.
A spring assembly comprising: A hook-less extension spring including a plurality of coils wound helically between first and second ends of the hook-less extension spring; and a pair of spring discs coupled to respective ends of the hook-less extension spring, wherein each spring disc includes a notch, a low notch end, and a high notch end, wherein one spring disc of the pair of spring discs is attached to the first end of the hook-less extension spring between a first end coil terminating the first end and a second end coil adjacent the first end coil, wherein the notch in the spring disc provides a passageway for the first coil to transition into the second end coil, wherein the spring assembly further comprises a feature on an end tip of the first end coil that engages the spring disc to lock the spring disc relative to the hook-less extension spring or to prevent movement of the spring disc relative to the hook-less extension spring, characterized in that, the feature on the end tip of the first end coil is a deformed tip configured to provide a tab end that interferes with the high notch end to prevent the spring disc from rotating out of the hook-less extension spring or is a notch created in the first end coil to prevent movement of the spring disc. A hook-less extension spring including a plurality of coils wound helically between first and second ends of the hook-less extension spring; and a pair of spring discs coupled to respective ends of the hook-less extension spring, wherein each spring disc includes a notch, a low notch end, and a high notch end, wherein one spring disc of the pair of spring discs is attached to the first end of the hook-less extension spring between a first end coil terminating the first end and a second end coil adjacent the first end coil, wherein the notch in the spring disc provides a passageway for the first coil to transition into the second end coil, wherein the spring assembly further comprises a feature on an end tip of the first end coil that engages the spring disc to lock the spring disc relative to the hook-less extension spring or to prevent movement of the spring disc relative to the hook-less extension spring, characterized in that, the feature on the end tip of the first end coil is a deformed tip configured to provide a tab end that interferes with the high notch end to prevent the spring disc from rotating out of the hook-less extension spring or is a notch created in the first end coil to prevent movement of the spring disc.
An isolated deoxyribonucleic acid molecule consisting of a nucleotide sequence that encodes a protein at least 95% identical to the amino acid sequence of SEQ ID NO:11, wherein the nucleotide sequence encodes a protein that when expressed in photoreceptor cells of a patient suffering from CEP290-related Leber congenital amaurosis, increases visual function of the patient.