mhurhangee/ep-ind-claims huggingface dataset:
A process for forming drug-loaded polymer particles comprising the steps: a) contacting particles comprising a matrix of water-insoluble polymer having a level of anion in the range 0.1 to 10 meq g -1, which forms a hydrogel on contact with water, which particles, when neat, are swellable in phosphate buffered saline at room temperature to an equilibrium water content in the range of from 40% to 99% by weight based on polymer plus PBS, with a solution of a drug having a water solubility of less than 0.1 g/l at room temperature, in a first organic solvent which is miscible with water; whereby a solution of drug in solvent becomes impregnated into the particles and the first solvent is selected to be capable of swelling neat particles; in which the ratio of drug solubilities at room temperature in the first organic solvent and water is in the range 10:1 to 10 6:1, preferably (at least 10 2):1; b) separating drug solution which has not impregnated the particles in step a) from the impregnated particles; c) contacting the impregnated particles with aqueous liquid whereby drug is precipitated in the core of the particles; and d) rinsing the particles with drug precipitated within the core with a volatile, second solvent in which the particles are less swellable, relative to their swellability in water, and which is a solvent for the drug, wherein the drug solubility in the second solvent is at least 0.1 g/l, whereby drug on and close to the surface of the particles is removed with the second solvent. a) contacting particles comprising a matrix of water-insoluble polymer having a level of anion in the range 0.1 to 10 meq g -1, which forms a hydrogel on contact with water, which particles, when neat, are swellable in phosphate buffered saline at room temperature to an equilibrium water content in the range of from 40% to 99% by weight based on polymer plus PBS, with a solution of a drug having a water solubility of less than 0.1 g/l at room temperature, in a first organic solvent which is miscible with water; whereby a solution of drug in solvent becomes impregnated into the particles and the first solvent is selected to be capable of swelling neat particles; in which the ratio of drug solubilities at room temperature in the first organic solvent and water is in the range 10:1 to 10 6:1, preferably (at least 10 2):1; b) separating drug solution which has not impregnated the particles in step a) from the impregnated particles; c) contacting the impregnated particles with aqueous liquid whereby drug is precipitated in the core of the particles; and d) rinsing the particles with drug precipitated within the core with a volatile, second solvent in which the particles are less swellable, relative to their swellability in water, and which is a solvent for the drug, wherein the drug solubility in the second solvent is at least 0.1 g/l, whereby drug on and close to the surface of the particles is removed with the second solvent.
A linear actuator system comprising at least a control device, a power supply, a linear actuator and an operating device, characterized in that it comprises at least one printed circuit board having multiple layers (29,31,32,35) comprising at least one electrically conductive circuit and where at least one of the layers of the printed circuit board is a detection layer for detecting a leakage current and where a voltage which falls outside of the working range of the electrically conductive circuit is applied to the detection layer.
A mobile device comprising: a transmitter arranged to transmit a signal for use by one or more location networks (4, 14) to determine a location of the mobile device; and a location preferences module configured to include in the transmission from the transmitter, in association with said signal, a tracking preference specifying whether a location network (4, 14) is permitted to use said signal to determine the location of the mobile device, and/or whether a provider of a location related service (14, 16) associated with a location network is permitted to make use of the location of the mobile device; wherein the mobile device comprises a receiver configured to receive a respective identifier of each of a plurality of location networks and/or providers, each provider being a provider of at least one respective location related service associated with one of said one or more location networks; wherein the tracking preference is dependent on the location network or provider as identified by said identifier; and wherein the location preferences module is configured to include in association with said signal: an instance of the tracking preference tagged with more than one of the identifiers to specify the permission permitted to each respective location network or provider, or more than one instance of the tracking preference each tagged with one of the identifiers to specify the permission permitted to each respective location network or provider. a transmitter arranged to transmit a signal for use by one or more location networks (4, 14) to determine a location of the mobile device; and a location preferences module configured to include in the transmission from the transmitter, in association with said signal, a tracking preference specifying whether a location network (4, 14) is permitted to use said signal to determine the location of the mobile device, and/or whether a provider of a location related service (14, 16) associated with a location network is permitted to make use of the location of the mobile device; wherein the mobile device comprises a receiver configured to receive a respective identifier of each of a plurality of location networks and/or providers, each provider being a provider of at least one respective location related service associated with one of said one or more location networks; wherein the tracking preference is dependent on the location network or provider as identified by said identifier; and wherein the location preferences module is configured to include in association with said signal: an instance of the tracking preference tagged with more than one of the identifiers to specify the permission permitted to each respective location network or provider, or more than one instance of the tracking preference each tagged with one of the identifiers to specify the permission permitted to each respective location network or provider.
A piece of furniture comprising a space, sliding doors (110, 112) guided in parallel for closing said space and having a closing system for said sliding doors (110, 112), comprising a first closing section for a first sliding door and a second closing section for a second sliding door, wherein said sliding sections (3, 5) partially overlap each other in a closed position, and comprising an automatic or remote-controllable closing device having a lock device, wherein said lock device cooperates with said first and said second closing section (3, 5) in a closed position, wherein said closing device is arranged on the side of said closing sections (3, 5) facing said space, and said lock device penetrates said first closing section from the side facing said space and engages said second closing section in the closed position, wherein said closing device comprises a drive which is arranged in a drive housing, characterized in that said drive housing comprises a vertical extension which is equal to or smaller than a vertical height of said first and/or said second closing section (3, 5).
An actuator substrate for the cultivation of biological cells, comprising at least one actuator unit, including an upper electrode and a lower electrode and an actuator element, which is arranged between the two electrodes and directly adjoins the upper and lower electrode and which is composed of at least one layer made of at least one electroactive polymer, the electrodes being arranged in the form of a layer or strips, protruding respectively beyond the EAP layer in at least one location in a direction extending parallel to the EAP layer, and these protrusions representing contact points for a voltage source.
A sensor for detecting or quantifying a target substance contained in a liquid sample, comprising: a PQQ-dependent or FAD-dependent enzyme that oxidizes or dehydrogenates the target substance; a quinone compound that accepts electrons released as a result of dehydrogenation or oxidization of the target substance by the enzyme; and at least a pair of electrodes (31, 32, 33), wherein the quinone compound contains a quinone and a substituent, wherein the substituent is hydrophilic, and wherein the redox potential of the quinone compound measured using a silver/silver chloride (saturated potassium chloride) electrode as a reference electrode is negative below 0V and more positive than the redox potential of the coenzyme, and wherein the redox potential of the quinone compound measured using a silver/silver chloride (saturated potassium chloride) electrode as a reference electrode is more negative than the oxidization potential of ascorbic acid, characterized in that the quinone compound is a 9,10-phenanthrenequinone-2-sulfonate. a PQQ-dependent or FAD-dependent enzyme that oxidizes or dehydrogenates the target substance; a quinone compound that accepts electrons released as a result of dehydrogenation or oxidization of the target substance by the enzyme; and at least a pair of electrodes (31, 32, 33), wherein the quinone compound contains a quinone and a substituent, wherein the substituent is hydrophilic, and
A method for providing multi-level classification of a network packet, the method comprising: (a) classifying, by a first classifier operating in a first portion of a network stack of a device, a packet of network traffic received via a network port as corresponding to a first predetermined application; (b) including with the packet, by the first classifier, an application identifier of the first predetermined application; (c) receiving, by a second classifier operating at layer of the network stack above the first portion, the packet communicated by the first classifier; (d) classifying, by the second classifier, the packet as corresponding to a second predetermined application; and (e) determining, by the second classifier, to use the first classifier's classification of the packet as corresponding to the first predetermined application identified by the application identifier instead of the second classifier's classification of the packet, responsive to a determination, from an application identifier list identifying application parent-child relationships, by the second classifier that the first predetermined application is more granular than the second predetermined application on the basis that an identifier of the first predetermined application is a child of an identifier of the second predetermined application. (a) classifying, by a first classifier operating in a first portion of a network stack of a device, a packet of network traffic received via a network port as corresponding to a first predetermined application; (b) including with the packet, by the first classifier, an application identifier of the first predetermined application; (c) receiving, by a second classifier operating at layer of the network stack above the first portion, the packet communicated by the first classifier; (d) classifying, by the second classifier, the packet as corresponding to a second predetermined application; and (e) determining, by the second classifier, to use the first classifier's classification of the packet as corresponding to the first predetermined application identified by the application identifier instead of the second classifier's classification of the packet, responsive to a determination, from an application identifier list identifying application parent-child relationships, by the second classifier that the first predetermined application is more granular than the second predetermined application on the basis that an identifier of the first predetermined application is a child of an identifier of the second predetermined application.
A system for transferring hazardous waste material into a sealable container, the system comprising: a container configured to sealingly contain the hazardous waste material, the container including the filling port, a filling nozzle having: a valve body having a distal end and an outer surface, the valve body including a valve seat, the outer surface proximate the distal end being configured to sealingly and removeably couple the valve body to an inner surface of a filling port of the container, a valve head having a valve face configured to form a seal with the valve seat in a closed configuration, the valve head configured to allow the valve body and the container to be fluidly coupled with one another in an open configuration in use, and a valve stem extending axially from the valve head through at least a portion of the valve body, characterised in that the valve seat and the seal are proximate the distal end; and in that, in the open configuration in use, the valve head extends distally from the valve body and into the container. a container configured to sealingly contain the hazardous waste material, the container including the filling port, a filling nozzle having: a valve body having a distal end and an outer surface, the valve body including a valve seat, the outer surface proximate the distal end being configured to sealingly and removeably couple the valve body to an inner surface of a filling port of the container, a valve head having a valve face configured to form a seal with the valve seat in a closed configuration, the valve head configured to allow the valve body and the container to be fluidly coupled with one another in an open configuration in use, and a valve stem extending axially from the valve head through at least a portion of the valve body, a valve body having a distal end and an outer surface, the valve body including a valve seat, the outer surface proximate the distal end being configured to sealingly and removeably couple the valve body to an inner surface of a filling port of the container, a valve head having a valve face configured to form a seal with the valve seat in a closed configuration, the valve head configured to allow the valve body and the container to be fluidly coupled with one another in an open configuration in use, and a valve stem extending axially from the valve head through at least a portion of the valve body, characterised in that the valve seat and the seal are proximate the distal end; and in that, in the open configuration in use, the valve head extends distally from the valve body and into the container.
A demand regulator (1, 101) for aircraft breathing device (100, 200) comprising: - a respiratory chamber supplied with respiratory gas comprising breathable gas and dilution gas, - a breathable gas supply line (12, 13) to be connected to a source of breathable gas and supplying the respiratory chamber with breathable gas, the breathable gas including high rate oxygen, - a dilution gas supply line (14, 15) to be connected to a source of dilution gas and supplying the respiratory chamber with dilution gas, - a first adjusting device (50, 60;160) adjusting the pressure in the respiratory chamber, and - a second adjusting device (22, 24, 40, 41-49) adjusting the rate of dilution gas in the respiratory gas supplied to the respiratory chamber, the second adjusting device comprising a dilution valve disposed in the dilution gas supply line (14, 15) and the dilution valve being movable between a retracted position and a protruded position, wherein the first adjusting device (50, 60; 160) is of non-electrical type and the second adjusting device (22, 24, 40, 41-49) comprises a sensor (41, 42, 43, 44, 45, 47, 48, 49) and an electrical control unit, the electrical control unit receiving a signal from the sensor and the electrical control unit adjusting the rate of dilution gas in the respiratory gas by controlling the dilution valve in function of said signal. - a respiratory chamber supplied with respiratory gas comprising breathable gas and dilution gas, - a breathable gas supply line (12, 13) to be connected to a source of breathable gas and supplying the respiratory chamber with breathable gas, the breathable gas including high rate oxygen, - a dilution gas supply line (14, 15) to be connected to a source of dilution gas and supplying the respiratory chamber with dilution gas, - a first adjusting device (50, 60;160) adjusting the pressure in the respiratory chamber, and - a second adjusting device (22, 24, 40, 41-49) adjusting the rate of dilution gas in the respiratory gas supplied to the respiratory chamber, the second adjusting device comprising a dilution valve disposed in the dilution gas supply line (14, 15) and the dilution valve being movable between a retracted position and a protruded position,
A stable pharmaceutical composition comprising fesoterodine fumarate, glyceryl behenate and a mixture of citric acid and pre-gelatinized starch as stabilizer.
A method for controlling the position of a floor of a carriage of a railway vehicle moving on rails, relatively to a platform, the carriage comprising a body and at least one bogie, the bogie including an axle, a bogie chassis, at least one primary suspension interposed between the axle and the bogie chassis, and at least one secondary suspension interposed between the primary suspension and the floor, the axle comprising wheels connected through a shaft, the method including the following steps: - measuring the height (H s) of the secondary suspension defined from a top of the bogie chassis, and - adjusting the height (H s) of the secondary suspension, according to the height (H pla) of the platform defined from the top of the rails for positioning the floor at the height (H pla) of the platform, characterized in that, the method comprises a step for estimating the height (H cb) of the top of the bogie chassis defined from the shaft of the axle, and a step for estimating the height of the shaft of the axle defined from the top of the rails, the adjustment of the height (H s) of the secondary suspension being achieved according to the estimated height (H cb) of the top of the bogie chassis defined from the shaft, and according to the estimated height of the shaft defined from the top of the rails. - measuring the height (H s) of the secondary suspension defined from a top of the bogie chassis, and - adjusting the height (H s) of the secondary suspension, according to the height (H pla) of the platform defined from the top of the rails for positioning the floor at the height (H pla) of the platform,
A method for producing a hydrogenated compound, comprising Step 1: the step of generating hydrogen by reacting water and a reduced compound in a solvent consisting of water, and Step 2: the step of producing the hydrogenated compound (c) by reducing a compound to be hydrogenated with the generated hydrogen at not lower than 120°C and not higher than 600°C, wherein the reduced compound is at least one selected from Zn and Fe, wherein the compound to be hydrogenated is at least one compound selected from the group consisting of vegetable fat and oil, cellulose, sucrose, glucose, fructose, xylose, sorbitol, lactic acid, furfural, phenol and glycerin, wherein a concentration of the compound to be hydrogenated as a raw material in the reaction mixture is not less than 1 mass% and not more than 60 mass%, and wherein the Step 1 and Step 2 are carried out in a one-pot way. Step 1: the step of generating hydrogen by reacting water and a reduced compound in a solvent consisting of water, and Step 2: the step of producing the hydrogenated compound (c) by reducing a compound to be hydrogenated with the generated hydrogen at not lower than 120°C and not higher than 600°C,
Aircraft nacelle comprising first and second ducts (78, 82), having first and second axes parallel to a longitudinal direction, the first duct comprising, in a radial direction, at least one first acoustically resistive layer, at least one first alveolar structure, as well as a first reflective layer, the second duct comprising, in a radial direction, at least one second acoustically resistive layer, at least one second alveolar structure, as well as a second reflective layer, the first and second ducts (78, 82) having aerodynamic surfaces, and being connected by a connection which comprises: - a first flange which is positioned on a plane perpendicular to the longitudinal direction, having a free first edge (100.1) and a second edge (100.2) which is connected to the first reflective layer of the first duct; - a second flange which is positioned on a plane perpendicular to the longitudinal direction, placed against the first flange, having a free first edge (102.1) and a second edge (102.2) which is connected to the second reflective layer of the second duct; - connection elements which are oriented parallel to the longitudinal direction, passing through the first and second flanges (100, 102), and maintaining them placed against one another, characterized in that, for each of the first and second ducts (78, 82), the first free edge (100.1, 102.1) of the first or second flange (100, 102) has a diameter which is smaller than that of its second edge (100.2, 102.2), wherein the first and second ducts (78, 82) are configured to form at least one receptacle opening at the aerodynamic surfaces, and in which the first and second flanges (100, 102) as well as the connection elements, are positioned, and wherein the connection comprises at least one cap which is configured to close the receptacle, which cap is connected to the first or second duct (78, 82), and has a surface flush with the aerodynamic surfaces of the first and second ducts (78, 82). - a first flange which is positioned on a plane perpendicular to the longitudinal direction, having a free first edge (100.1) and a second edge (100.2) which is connected to the first reflective layer of the first duct; - a second flange which is positioned on a plane perpendicular to the longitudinal direction, placed against the first flange, having a free first edge (102.1) and a second edge (102.2) which is connected to the second reflective layer of the second duct; - connection elements which are oriented parallel to the longitudinal direction, passing through the first and second flanges (100, 102), and maintaining them placed against one another,
A method performed in a broadcast multicast service center, BM-SC, node for providing an on-request service to an end-user device, the method comprising: - obtaining, from a content delivery node, the size of a file of the on-request service, - determining, based on the obtained file size, one or more parameters related to encoding of the file, thereby establishing a virtual partitioning of the file into a number Z of source blocks, - downloading, from the content delivery node, a source block of the file according to the determined one or more parameters, - encoding the source block of the file into encoding symbols according to the determined one or more parameters, and - providing the encoding symbols for delivery to the end-user device. - obtaining, from a content delivery node, the size of a file of the on-request service, - determining, based on the obtained file size, one or more parameters related to encoding of the file, thereby establishing a virtual partitioning of the file into a number Z of source blocks, - downloading, from the content delivery node, a source block of the file according to the determined one or more parameters, - encoding the source block of the file into encoding symbols according to the determined one or more parameters, and - providing the encoding symbols for delivery to the end-user device.