A compound of Formula: or an isotopically labeled analog, pharmaceutically acceptable salt, solvate, stereoisomer, or mixture of stereoisomers thereof, wherein: Z 1 and Z 2 are each independently CH, or one of Z 1 and Z 2 is N and the other is CH; Z 3 is N or CH; L 1 is -O-C 1-4 alkylene; one of X 1 and X 2 is N-L 2 -R 2 and the other is CH 2; X 3 is CH 2 or -O-CH 2 -; L 2 is -(CH 2) n -, -C(=O)-, -C(=O)NH-, -C(=O) -(CH 2) n, or -S(=O) 2; n is 0, 1, or 2; R 1 is heteroaryl optionally substituted with one or two substituents independently selected from hydroxy, alkyl, alkoxy, haloalkoxy, and -N(R 4) 2; R 2 is heteroaryl, heterocycloalkyl, or heterocycloalkenyl, each of which is optionally substituted with one or two substituents independently selected from halogen, haloalkyl, hydroxy, alkyl optionally substituted with alkenyl or alkoxy, alkoxy optionally substituted with alkenyl or alkoxy, haloalkoxy, heteroaryl, and -N(R 4) 2; p is 0, 1, or 2; each R 3 is independently C 1-4 alkyl, or two R 3 on the same carbon form oxo, where R 3 may substitute one or more ring carbon atoms of and each R 4 is independently H or C 1-4 alkyl. or an isotopically labeled analog, pharmaceutically acceptable salt, solvate, stereoisomer, or mixture of stereoisomers thereof, wherein: Z 1 and Z 2 are each independently CH, or one of Z 1 and Z 2 is N and the other is CH; Z 3 is N or CH; L 1 is -O-C 1-4 alkylene; one of X 1 and X 2 is N-L 2 -R 2 and the other is CH 2; X 3 is CH 2 or -O-CH 2 -; L 2 is -(CH 2) n -, -C(=O)-, -C(=O)NH-, -C(=O) -(CH 2) n, or -S(=O) 2; n is 0, 1, or 2; R 1 is heteroaryl optionally substituted with one or two substituents independently selected from hydroxy, alkyl, alkoxy, haloalkoxy, and -N(R 4) 2; R 2 is heteroaryl, heterocycloalkyl, or heterocycloalkenyl, each of which is optionally substituted with one or two substituents independently selected from halogen, haloalkyl, hydroxy, alkyl optionally substituted with alkenyl or alkoxy, alkoxy optionally substituted with alkenyl or alkoxy, haloalkoxy, heteroaryl, and -N(R 4) 2; p is 0, 1, or 2; each R 3 is independently C 1-4 alkyl, or two R 3 on the same carbon form oxo, where R 3 may substitute one or more ring carbon atoms of and each R 4 is independently H or C 1-4 alkyl. Z 1 and Z 2 are each independently CH, or one of Z 1 and Z 2 is N and the other is CH; Z 3 is N or CH; L 1 is -O-C 1-4 alkylene; one of X 1 and X 2 is N-L 2 -R 2 and the other is CH 2; X 3 is CH 2 or -O-CH 2 -; L 2 is -(CH 2) n -, -C(=O)-, -C(=O)NH-, -C(=O) -(CH 2) n, or -S(=O) 2; n is 0, 1, or 2; R 1 is heteroaryl optionally substituted with one or two substituents independently selected from hydroxy, alkyl, alkoxy, haloalkoxy, and -N(R 4) 2; R 2 is heteroaryl, heterocycloalkyl, or heterocycloalkenyl, each of which is optionally substituted with one or two substituents independently selected from halogen, haloalkyl, hydroxy, alkyl optionally substituted with alkenyl or alkoxy, alkoxy optionally substituted with alkenyl or alkoxy, haloalkoxy, heteroaryl, and -N(R 4) 2; p is 0, 1, or 2; each R 3 is independently C 1-4 alkyl, or two R 3 on the same carbon form oxo, where R 3 may substitute one or more ring carbon atoms of and each R 4 is independently H or C 1-4 alkyl.