A medical shoe comprising: a frame comprising a plurality of through holes (36, 37, 38, 40, 41, 42, 43, 44, 46), an overmolding layer extending from a side of the frame so as to form a ground contacting surface, said overmolding layer having a non-uniform density, and a midsole configured to support a foot, the midsole comprising: a foot receiving portion forming a substantially planar surface for supporting the foot, and a frame receiving portion opposite the foot receiving portion, wherein said overmolding layer extends from a side of the frame opposite the midsole, and wherein the frame surrounds the midsole which is secured to the frame by a self-locking fit between the midsole and the frame, wherein the midsole further comprises a midsole lip portion extending around a circumferential edge of the midsole in a direction perpendicular to the substantially planar surface, and the frame further comprises a frame lip portion surrounding the midsole lip portion such that a contour of an inner surface of the frame lip potion corresponds to a contour of an outer surface of the midsole lip portion, and wherein the midsole lip portion interacts with the frame lip portion for establishing a snap fit which comprises a frictional force between the midsole and the frame, characterised in that the midsole further comprises a fixation projection extending from the midsole lip portion in a direction parallel to the substantially planar surface, the frame further comprises a fixation projection through hole in the frame lip portion, and the fixation projection extends into the fixation projection through hole. a frame comprising a plurality of through holes (36, 37, 38, 40, 41, 42, 43, 44, 46), an overmolding layer extending from a side of the frame so as to form a ground contacting surface, said overmolding layer having a non-uniform density, and a midsole configured to support a foot, the midsole comprising: a foot receiving portion forming a substantially planar surface for supporting the foot, and a frame receiving portion opposite the foot receiving portion, a foot receiving portion forming a substantially planar surface for supporting the foot, and a frame receiving portion opposite the foot receiving portion, wherein said overmolding layer extends from a side of the frame opposite the midsole, and wherein the frame surrounds the midsole which is secured to the frame by a self-locking fit between the midsole and the frame, wherein the midsole further comprises a midsole lip portion extending around a circumferential edge of the midsole in a direction perpendicular to the substantially planar surface, and the frame further comprises a frame lip portion surrounding the midsole lip portion such that a contour of an inner surface of the frame lip potion corresponds to a contour of an outer surface of the midsole lip portion, and wherein the midsole lip portion interacts with the frame lip portion for establishing a snap fit which comprises a frictional force between the midsole and the frame, characterised in that the midsole further comprises a fixation projection extending from the midsole lip portion in a direction parallel to the substantially planar surface, the frame further comprises a fixation projection through hole in the frame lip portion, and the fixation projection extends into the fixation projection through hole.