A method of calculating a single, fused sensor glucose value based on respective glucose measurement signals of a plurality of redundant sensing electrodes, comprising: performing respective electrochemical impedance spectroscopy procedures for each of the plurality of redundant sensing electrodes to obtain values of at least one impedance-based parameter selected from the group comprising real impedance; imaginary impedance and Nyquist slope for each said sensing electrode wherein the at least one impedance-based parameter includes the real impedance; measuring the electrode current (Isig) for each of the plurality of redundant sensing electrodes; independently calibrating each of the measured Isigs to obtain respective calibrated sensor glucose values; performing a bound check and a noise check on said measured Isig and said values of the at least one impedance-based parameter and assigning a bound-check reliability index and a noise-check reliability index to each said sensing electrode; performing signal-dip analysis based on one or more of said at least one impedance-based parameter and assigning a dip reliability index to each said sensing electrode, whereby signal-dip is determined to exist if, as the measured electrode current (Isig) decreases, the real impedance increases; performing sensitivity-loss analysis based on one or more of said at least one impedance-based parameter and assigning a sensitivity-loss index to each said sensing electrode; for each of the plurality of electrodes, calculating a total reliability index based on said electrode's bound-check reliability index, noise-check reliability index, dip reliability index, and sensitivity-loss reliability index; for each of the plurality of electrodes, calculating a weight based on said electrode's total reliability index; and calculating said single, fused sensor glucose value based on the respective weights and calibrated sensor glucose values of each of the plurality of redundant sensing electrodes. performing respective electrochemical impedance spectroscopy procedures for each of the plurality of redundant sensing electrodes to obtain values of at least one impedance-based parameter selected from the group comprising real impedance; imaginary impedance and Nyquist slope for each said sensing electrode wherein the at least one impedance-based parameter includes the real impedance; measuring the electrode current (Isig) for each of the plurality of redundant sensing electrodes; independently calibrating each of the measured Isigs to obtain respective calibrated sensor glucose values; performing a bound check and a noise check on said measured Isig and said values of the at least one impedance-based parameter and assigning a bound-check reliability index and a noise-check reliability index to each said sensing electrode; performing signal-dip analysis based on one or more of said at least one impedance-based parameter and assigning a dip reliability index to each said sensing electrode, whereby signal-dip is determined to exist if, as the measured electrode current (Isig) decreases, the real impedance increases; performing sensitivity-loss analysis based on one or more of said at least one impedance-based parameter and assigning a sensitivity-loss index to each said sensing electrode; for each of the plurality of electrodes, calculating a total reliability index based on said electrode's bound-check reliability index, noise-check reliability index, dip reliability index, and sensitivity-loss reliability index; for each of the plurality of electrodes, calculating a weight based on said electrode's total reliability index; and calculating said single, fused sensor glucose value based on the respective weights and calibrated sensor glucose values of each of the plurality of redundant sensing electrodes.