A compound of Formula wherein R 1 is phenyl or monocyclic 5-6 membered heteroaryl, each optionally substituted with one or more substituents selected from halogen, C 1 -C 6 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, amino, N-C 1 -C 3 alkylamino and N,N-diC 1 -C 3 alkylamino; R 2 is selected from hydrogen, C 1 -C 3 haloalkyl and C 1 -C 3 alkyl; R 3 is selected from A, phenyl and monocyclic heteroaryl, said phenyl and said heteroaryl being each optionally substituted with one or more of R 4, R 5, R 6 and R 7; R 4, R 5, R 6 and R 7 are independently selected from halogen, C 1 -C 6 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, azetidine, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino, NHSO 2 R 8, SO 2 R 9 and hydroxy; R 8 is C 1 -C 3 haloalkyl or C 1 -C 3 alkyl; R 9 is selected from R 10, C 1 -C 6 alkyl, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino and C 1 -C 3 alkoxyC 1 -C 3 alkyl, wherein said C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl being each optionally substituted with one R 10 and/or one or more halogen; R 10 is selected from phenyl, benzyl, monocyclic heteroaryl, C 3 -C 6 cycloalkyl, heterocyclyl, each optionally substituted with one or more R 11; R 11 is selected from halogen, C 1 -C 3 haloalkyl, C 3 -C 4 cycloalkyl, C 1 -C 3 alkyl, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino and C 1 -C 3 alkoxyC 1 -C 3 alkyl; A is R 12 is selected from hydrogen, halogen, COR 13, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 alkoxyC 1 -C 3 alkyl, C 1 -C 6 alkoxy, C 1 -C 3 cyanoalkyl, and C 1 -C 3 haloalkyl; R 13 is selected from C 1 -C 3 alkoxy, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino, 1-pyrrolidinyl, 1-piperidinyl and 1-azetidinyl; Y is selected from CH 2, S, SO, SO 2, NR 14, NCOR 9, NCOOR 15, NSO 2 R 9, NCOCH 2 R 9, O, or a bond; R 14 is selected from H, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxyC 1 -C 3 alkyl, C 1 -C 3 alkyl, and C 3 -C 6 cycloalkyl; R 15 is selected from R 10, C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl, and wherein said C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl being each optionally substituted with one R 10 and/or one or more halogen; and Z is CH or N; or a pharmaceutically acceptable salt thereof. R 1 is phenyl or monocyclic 5-6 membered heteroaryl, each optionally substituted with one or more substituents selected from halogen, C 1 -C 6 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, amino, N-C 1 -C 3 alkylamino and N,N-diC 1 -C 3 alkylamino; R 2 is selected from hydrogen, C 1 -C 3 haloalkyl and C 1 -C 3 alkyl; R 3 is selected from A, phenyl and monocyclic heteroaryl, said phenyl and said heteroaryl being each optionally substituted with one or more of R 4, R 5, R 6 and R 7; R 4, R 5, R 6 and R 7 are independently selected from halogen, C 1 -C 6 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, azetidine, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino, NHSO 2 R 8, SO 2 R 9 and hydroxy; R 8 is C 1 -C 3 haloalkyl or C 1 -C 3 alkyl; R 9 is selected from R 10, C 1 -C 6 alkyl, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino and C 1 -C 3 alkoxyC 1 -C 3 alkyl, wherein said C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl being each optionally substituted with one R 10 and/or one or more halogen; R 10 is selected from phenyl, benzyl, monocyclic heteroaryl, C 3 -C 6 cycloalkyl, heterocyclyl, each optionally substituted with one or more R 11; R 11 is selected from halogen, C 1 -C 3 haloalkyl, C 3 -C 4 cycloalkyl, C 1 -C 3 alkyl, amino, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino and C 1 -C 3 alkoxyC 1 -C 3 alkyl; A is R 12 is selected from hydrogen, halogen, COR 13, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 3 alkoxyC 1 -C 3 alkyl, C 1 -C 6 alkoxy, C 1 -C 3 cyanoalkyl, and C 1 -C 3 haloalkyl; R 13 is selected from C 1 -C 3 alkoxy, N-C 1 -C 3 alkylamino, N,N-diC 1 -C 3 alkylamino, 1-pyrrolidinyl, 1-piperidinyl and 1-azetidinyl; Y is selected from CH 2, S, SO, SO 2, NR 14, NCOR 9, NCOOR 15, NSO 2 R 9, NCOCH 2 R 9, O, or a bond; R 14 is selected from H, C 1 -C 3 haloalkyl, C 1 -C 3 alkoxyC 1 -C 3 alkyl, C 1 -C 3 alkyl, and C 3 -C 6 cycloalkyl; R 15 is selected from R 10, C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl, and wherein said C 1 -C 6 alkyl and C 1 -C 3 alkoxyC 1 -C 3 alkyl being each optionally substituted with one R 10 and/or one or more halogen; and Z is CH or N; or a pharmaceutically acceptable salt thereof.