A compound, or a pharmaceutically acceptable salt or ester thereof having Formula II-i wherein R 1 is an optionally substituted alkyl, optionally substituted alkenyl, alkynyl, haloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocycle, optionally substituted heterocycle, halo, H, optionally substituted alkoxy, optionally substituted amino, cyano, or optionally substituted arylalkyl; R 4 is halo or R 5 is null, H, or C 1 -C 6 alkyl; and R 10 is C, N, O, or S; wherein the term "alkyl" means an alkyl group containing from 1 to 20 carbon atoms; wherein the terms "alkenyl" and "alkynyl" mean an alkenyl or alkynyl group containing from 2 to 20 carbon atoms; wherein the term "aryl" means a monocyclic, bicyclic or polycyclic having 2, 3 or 4 fused rings aromatic hydrocarbon having from 6 to 20 carbon atoms; wherein the term "heteroaryl" means an aromatic heterocycle having up to 20 ring-forming carbon atoms and at least one heteroatom ring member selected from the group consisting of: sulfur, oxygen and nitrogen; wherein the term "carbocycle" means a 5- or 6-membered, saturated or unsaturated ring; wherein the term "heterocycle" means a 5- to 7-membered mono- or bicyclic, or 7- to 10-membered bicyclic ring system any ring of which may be saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms chosen from N, O or S; wherein the optional substitution is selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkenyl,C 1 -C 6 alkynyl, C 5 -C 6 aryl, C 1 -C 6 alkoxy, C 3 -C 5 heteroaryl, C 3 -C 6 cycloalkyl, C 5 -C 6 aryloxy, -CN, -OH, oxo, halo, haloalkyl, -NO 2, -CO 2 H, -NH 2, -NH(C 1 -C 8 alkyl), -N(C 1 -C 8 alkyl) 2, -NH(C 6 aryl), -N(C 5 -C 6 aryl) 2, -CHO, -CO(C 1 -C 6 alkyl), -CO((C 5 -C 6)aryl),-CO 2 ((C 1 -C 6)alkyl), and -CO 2 ((C 5 -C 6)aryl). R 1 is an optionally substituted alkyl, optionally substituted alkenyl, alkynyl, haloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocycle, optionally substituted heterocycle, halo, H, optionally substituted alkoxy, optionally substituted amino, cyano, or optionally substituted arylalkyl; R 4 is halo or R 5 is null, H, or C 1 -C 6 alkyl; and R 10 is C, N, O, or S; wherein the term "alkyl" means an alkyl group containing from 1 to 20 carbon atoms; wherein the terms "alkenyl" and "alkynyl" mean an alkenyl or alkynyl group containing from 2 to 20 carbon atoms; wherein the term "aryl" means a monocyclic, bicyclic or polycyclic having 2, 3 or 4 fused rings aromatic hydrocarbon having from 6 to 20 carbon atoms; wherein the term "heteroaryl" means an aromatic heterocycle having up to 20 ring-forming carbon atoms and at least one heteroatom ring member selected from the group consisting of: sulfur, oxygen and nitrogen; wherein the term "carbocycle" means a 5- or 6-membered, saturated or unsaturated ring; wherein the term "heterocycle" means a 5- to 7-membered mono- or bicyclic, or 7- to 10-membered bicyclic ring system any ring of which may be saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms chosen from N, O or S; wherein the optional substitution is selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkenyl,C 1 -C 6 alkynyl, C 5 -C 6 aryl, C 1 -C 6 alkoxy, C 3 -C 5 heteroaryl, C 3 -C 6 cycloalkyl, C 5 -C 6 aryloxy, -CN, -OH, oxo, halo, haloalkyl, -NO 2, -CO 2 H, -NH 2, -NH(C 1 -C 8 alkyl), -N(C 1 -C 8 alkyl) 2, -NH(C 6 aryl), -N(C 5 -C 6 aryl) 2, -CHO, -CO(C 1 -C 6 alkyl), -CO((C 5 -C 6)aryl),-CO 2 ((C 1 -C 6)alkyl), and -CO 2 ((C 5 -C 6)aryl).