A pharmaceutical composition comprising: (a) a water-insoluble antipsychotic agent, wherein the water-insoluble antipsychotic agent is aripiprazole, a compound of formula I, or a compound of formula II, or pharmaceutically acceptable salts, hydrates, or solvates thereof: wherein R a is absent, and R b is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; or R b is absent, and R a is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; R c is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; wherein each R 1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic, and substituted or unsubstituted aryl; and wherein the substituted aliphatic, aryl, or heteroaryl are substituted with one or more substituents selected from the group consisting of halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, aralkoxycarbonyl, carboxylic acid, sulfonic acid, sulfonyl, phosphonic acid, aryl, heteroaryl, heterocyclic, and aliphatic; wherein each R 2 is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; wherein Y ⊖ is a pharmaceutically acceptable counterion; and wherein ------------ represents a single or double bond; (b) a glycerol ester of a fatty acid, wherein the glycerol ester of a fatty acid is sesame oil; and (c) an aqueous vehicle; wherein the composition forms an aqueous, flocculated, injectable suspension. (a) a water-insoluble antipsychotic agent, wherein the water-insoluble antipsychotic agent is aripiprazole, a compound of formula I, or a compound of formula II, or pharmaceutically acceptable salts, hydrates, or solvates thereof: wherein R a is absent, and R b is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; or R b is absent, and R a is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; R c is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; wherein each R 1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic, and substituted or unsubstituted aryl; and wherein the substituted aliphatic, aryl, or heteroaryl are substituted with one or more substituents selected from the group consisting of halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, aralkoxycarbonyl, carboxylic acid, sulfonic acid, sulfonyl, phosphonic acid, aryl, heteroaryl, heterocyclic, and aliphatic; wherein each R 2 is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; wherein Y ⊖ is a pharmaceutically acceptable counterion; and wherein ------------ represents a single or double bond; R a is absent, and R b is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; or R b is absent, and R a is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; R c is -CH 2 OC R 1, -CH 2 OC OR 1, -CH 2 OC N(R 1) 2 or -C R 1; wherein each R 1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic, and substituted or unsubstituted aryl; and wherein the substituted aliphatic, aryl, or heteroaryl are substituted with one or more substituents selected from the group consisting of halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, aralkoxycarbonyl, carboxylic acid, sulfonic acid, sulfonyl, phosphonic acid, aryl, heteroaryl, heterocyclic, and aliphatic; wherein each R 2 is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; wherein Y ⊖ is a pharmaceutically acceptable counterion; and (b) a glycerol ester of a fatty acid, wherein the glycerol ester of a fatty acid is sesame oil; and (c) an aqueous vehicle; wherein the composition forms an aqueous, flocculated, injectable suspension.