A method for nucleic acid isolation comprising: • receiving a binding moiety solution within a process chamber, wherein the binding moiety solution comprises a collection buffer and a set of affinity moiety-coated magnetic microparticles modified with carboxyl functional groups, wherein the set of affinity moiety-coated magnetic microparticles comprise Polypropylenimine tetramine dendrimer (DABAM) (Generation 1) amide-bonded to the set of magnetic microparticles by way of the carboxyl functional groups; • contacting the binding moiety solution with a biological sample, within the process chamber, thereby producing a moiety-sample mixture; • incubating the moiety-sample mixture to reversibly bind nucleic acid material of the biological sample to the set of affinity moiety-coated microparticles, thereby producing a set of moiety-bound nucleic acid particles; • magnetically separating the set of moiety-bound nucleic acid particles from the moiety-sample mixture, wherein magnetically separating the set of moiety-bound nucleic acid particles comprises: ∘ occluding a fluidic pathway of a microfluidic cartridge at a set of occlusion positions; and ∘ delivering the moiety-sample mixture into the fluidic pathway, wherein the fluidic pathway is configured to pass through a magnetic field; • washing the set of moiety-bound nucleic acid particles; and • releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles with an elution solution characterized by a pH greater than 10. • receiving a binding moiety solution within a process chamber, wherein the binding moiety solution comprises a collection buffer and a set of affinity moiety-coated magnetic microparticles modified with carboxyl functional groups, wherein the set of affinity moiety-coated magnetic microparticles comprise Polypropylenimine tetramine dendrimer (DABAM) (Generation 1) amide-bonded to the set of magnetic microparticles by way of the carboxyl functional groups; • contacting the binding moiety solution with a biological sample, within the process chamber, thereby producing a moiety-sample mixture; • incubating the moiety-sample mixture to reversibly bind nucleic acid material of the biological sample to the set of affinity moiety-coated microparticles, thereby producing a set of moiety-bound nucleic acid particles; • magnetically separating the set of moiety-bound nucleic acid particles from the moiety-sample mixture, wherein magnetically separating the set of moiety-bound nucleic acid particles comprises: ∘ occluding a fluidic pathway of a microfluidic cartridge at a set of occlusion positions; and ∘ delivering the moiety-sample mixture into the fluidic pathway, wherein the fluidic pathway is configured to pass through a magnetic field; ∘ occluding a fluidic pathway of a microfluidic cartridge at a set of occlusion positions; and ∘ delivering the moiety-sample mixture into the fluidic pathway, wherein the fluidic pathway is configured to pass through a magnetic field; • washing the set of moiety-bound nucleic acid particles; and • releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles with an elution solution characterized by a pH greater than 10.