A device for nanopore sensing, said device comprising: a structure arranged to separate an analyte reservoir and an outlet chamber, the structure comprising: a nanopore layer incorporating an array of wells, each well having a membrane that spans the well and has a nanopore provided therein, and each well having a well outlet; and a base layer incorporating an array of channels, the nanopore layer and the base layer being sandwiched together such that respective wells and channels are aligned to define an array of nanopore structures, wherein each nanopore structure comprises a passage defined at least in part by: a nanopore and a well of the nanopore layer, at one side of the passage; and a channel of the base layer, at the other side of the passage, wherein the well is fluidly connected to the channel via the well outlet, and the passages provide fluid connection through the structure between the analyte reservoir and outlet chamber; drive electrodes connected respectively in the analyte reservoir and the outlet chamber for imposing an electrical potential difference across the passages; electrical transduction elements, each electrical transduction element being exposed to the passage of a respective nanopore structure for measuring the fluidic electrical potential at that electrical transduction element in that nanopore structure; characterised by control terminals, wherein either: each control terminal is connected to the electrical transduction element of a respective nanopore structure; or the structure further comprises control electrodes, each control electrode being exposed to the passage of a respective nanopore structure, and each control terminal is connected to the control electrode of a respective nanopore structure, and the device is configured so that application of a control signal to a control terminal alters the electrical potential difference across the respective nanopore structure between the control terminal and at least one of the drive electrodes. a structure arranged to separate an analyte reservoir and an outlet chamber, the structure comprising: a nanopore layer incorporating an array of wells, each well having a membrane that spans the well and has a nanopore provided therein, and each well having a well outlet; and a base layer incorporating an array of channels, a nanopore layer incorporating an array of wells, each well having a membrane that spans the well and has a nanopore provided therein, and each well having a well outlet; and a base layer incorporating an array of channels, the nanopore layer and the base layer being sandwiched together such that respective wells and channels are aligned to define an array of nanopore structures, wherein each nanopore structure comprises a passage defined at least in part by: a nanopore and a well of the nanopore layer, at one side of the passage; and a channel of the base layer, at the other side of the passage, wherein the well is fluidly connected to the channel via the well outlet, and the passages provide fluid connection through the structure between the analyte reservoir and outlet chamber; drive electrodes connected respectively in the analyte reservoir and the outlet chamber for imposing an electrical potential difference across the passages; electrical transduction elements, each electrical transduction element being exposed to the passage of a respective nanopore structure for measuring the fluidic electrical potential at that electrical transduction element in that nanopore structure; characterised by control terminals, wherein either: each control terminal is connected to the electrical transduction element of a respective nanopore structure; or the structure further comprises control electrodes, each control electrode being exposed to the passage of a respective nanopore structure, and each control terminal is connected to the control electrode of a respective nanopore structure, and each control terminal is connected to the electrical transduction element of a respective nanopore structure; or the structure further comprises control electrodes, each control electrode being exposed to the passage of a respective nanopore structure, and each control terminal is connected to the control electrode of a respective nanopore structure, and the device is configured so that application of a control signal to a control terminal alters the electrical potential difference across the respective nanopore structure between the control terminal and at least one of the drive electrodes.