A method of making a fast-melting pharmaceutical tablet, comprising: (i-a) combining a water soluble or water dispersible, porous, plastic substance and a spray-dried porous water penetration enhancer to form an admixture thereof; (i-b) treating the admixture with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a mass of agglomerated particles thereof; (i-c) sieving and/or drying the agglomerated particles so as to isolate a plurality of highly plastic granules; and (i-d) compressing the highly plastic granules under low pressure of less than 150 MPa to afford the fast melting tablet; or alternatively: (ii-a) treating a water soluble or water dispersible, porous, plastic substance with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a first mass of agglomerated particles thereof; (ii-b) treating a spray-dried porous water penetration enhancer with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a second mass of agglomerated particles thereof; (ii-c) sieving, admixing and drying said masses of agglomerated particles together so as to isolate a plurality of highly plastic granules; and (ii-d) compressing the highly plastic granules under low pressure of less than 150 MPa to afford the fast melting tablet; wherein the porous, plastic substance and the porous water penetration enhancer are different substances, wherein the spray-dried porous water penetration enhancer comprises 10 to 95% by weight of the whole tablet, wherein the binder is selected from the group consisting of dextrates, dextrin, dextrose, fructose, lactitol, lactose, maltitol, maltose, mannitol, mannose, sorbitol, sucrose, erythritol, xylitol, starch, gelatin, acacia, alginic acid, sodium alginate, cellulose, carboxymethylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methylcellulose, polydextrose, poly(acrylic acid), CARBOMER, poly(ethylene oxide), and povidone, and wherein the term "highly plastic granules" refers to those granules whenever 500 mg of the granules, compressed into a 1.27 cm (0.5-inch) diameter die at a pressure less than 6672 N (1,500 pounds), exhibit a hardness of the formed tablet greater than 7 Newton. (i-a) combining a water soluble or water dispersible, porous, plastic substance and a spray-dried porous water penetration enhancer to form an admixture thereof; (i-b) treating the admixture with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a mass of agglomerated particles thereof; (i-c) sieving and/or drying the agglomerated particles so as to isolate a plurality of highly plastic granules; and (i-d) compressing the highly plastic granules under low pressure of less than 150 MPa to afford the fast melting tablet; (ii-a) treating a water soluble or water dispersible, porous, plastic substance with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a first mass of agglomerated particles thereof; (ii-b) treating a spray-dried porous water penetration enhancer with a binder solution, wherein the binder solution consists of a binder dissolved in an aqueous solution or a mixture of water and an organic solvent and the amount of the binder is effective to form a second mass of agglomerated particles thereof; (ii-c) sieving, admixing and drying said masses of agglomerated particles together so as to isolate a plurality of highly plastic granules; and (ii-d) compressing the highly plastic granules under low pressure of less than 150 MPa to afford the fast melting tablet;