A system for delivering an energy-based treatment to a tissue proximate a blood vessel, the system comprising: (a) an elongate catheter including an expandable structure at or near a distal end of the catheter, the expandable structure including an outer surface and at least one flexible circuit mounted on the outer surface of the expandable structure, the at least one flexible circuit including a first insulating layer, at least one heat sensing device positioned at least partially within the first insulating layer, a conductive layer above the first insulating layer, at least a portion of which being electrically coupled to the heat sensing device, a second insulating layer above the conductive layer, and a plurality of electrodes associated with the conductive layer, at least some of the electrodes are longitudinally spaced apart along the expandable structure; (b) a power source electrically coupled to the plurality of electrodes; and (c) a processor configured to verify whether at least some of the plurality of electrodes are in contact with the tissue by measuring an impedance of an electrical circuit associated with each of the at least some of the plurality of electrodes and determining whether the measured impedance is within a pre-designated range, wherein the processor is configured to energize at least one of the plurality of electrodes if the measured impedance is within the pre-designated range such that at least one of the plurality of electrodes is verified as in contact with the tissue, wherein the processor is configured to control the delivery of energy to regulate one or more parameters of the energy treatment based on monitoring feedback from electrical circuits associated with the at least some of the plurality of electrodes such that more or less energy is delivered to a treatment zone to heat the tissue therein to a temperature of 55°C to 75°C while tissue collateral to the treatment zone is heated to less than 45°C. (a) an elongate catheter including an expandable structure at or near a distal end of the catheter, the expandable structure including an outer surface and at least one flexible circuit mounted on the outer surface of the expandable structure, the at least one flexible circuit including a first insulating layer, at least one heat sensing device positioned at least partially within the first insulating layer, a conductive layer above the first insulating layer, at least a portion of which being electrically coupled to the heat sensing device, a second insulating layer above the conductive layer, and a plurality of electrodes associated with the conductive layer, at least some of the electrodes are longitudinally spaced apart along the expandable structure; (b) a power source electrically coupled to the plurality of electrodes; and (c) a processor configured to verify whether at least some of the plurality of electrodes are in contact with the tissue by measuring an impedance of an electrical circuit associated with each of the at least some of the plurality of electrodes and determining whether the measured impedance is within a pre-designated range, wherein the processor is configured to energize at least one of the plurality of electrodes if the measured impedance is within the pre-designated range such that at least one of the plurality of electrodes is verified as in contact with the tissue, wherein the processor is configured to control the delivery of energy to regulate one or more parameters of the energy treatment based on monitoring feedback from electrical circuits associated with the at least some of the plurality of electrodes such that more or less energy is delivered to a treatment zone to heat the tissue therein to a temperature of 55°C to 75°C while tissue collateral to the treatment zone is heated to less than 45°C.