A method of calibrating a computed tomography system when a field of view is partially obstructed by an object, comprising: acquiring a projection from a calibration procedure performed while the field of view was partially obstructed by the object, the projection comprising object projection data indicative of radiation that traversed the object and calibration projection data indicative of radiation that did not traverse the object; acquiring a second projection from the calibration procedure, the second projection comprising second object projection data indicative of radiation that traversed the object and second calibration projection data indicative of radiation that did not traverse the object, the projection representative of measurements acquired during a first rotation of at least one of a detector array or a radiation source of the CT system relative to the object and the second projection representative of measurements acquired during a second rotation, the object located at a first position relative to an axis of rotation for at least one of the detector array or the radiation source during the first rotation and located at a second position relative to the axis of rotation during the second rotation; separating the calibration projection data from the object projection data; separating the second calibration projection data from the second object projection data; compiling the calibration projection data of the projection with the second calibration projection data of the second projection to generate compiled calibration projection data; and computing one or more gain corrections as a function of the compiled calibration projection data, the one or more gain corrections utilized during an examination procedure to correct measurements yielded from the detector array of the CT system. acquiring a projection from a calibration procedure performed while the field of view was partially obstructed by the object, the projection comprising object projection data indicative of radiation that traversed the object and calibration projection data indicative of radiation that did not traverse the object; acquiring a second projection from the calibration procedure, the second projection comprising second object projection data indicative of radiation that traversed the object and second calibration projection data indicative of radiation that did not traverse the object, the projection representative of measurements acquired during a first rotation of at least one of a detector array or a radiation source of the CT system relative to the object and the second projection representative of measurements acquired during a second rotation, the object located at a first position relative to an axis of rotation for at least one of the detector array or the radiation source during the first rotation and located at a second position relative to the axis of rotation during the second rotation; separating the calibration projection data from the object projection data; separating the second calibration projection data from the second object projection data; compiling the calibration projection data of the projection with the second calibration projection data of the second projection to generate compiled calibration projection data; and computing one or more gain corrections as a function of the compiled calibration projection data, the one or more gain corrections utilized during an examination procedure to correct measurements yielded from the detector array of the CT system.