A compound of Formula: or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof, wherein: D is L 1 is CH 2 O-* or CH 2 OCH 2 -*, L 2 is selected from CH 2 O-*, CH 2 OCH 2 -*, or -O-, and "-*" indicates the attachment point to A or Z, respectively; R 1 is hydrogen or C 1 -C 6 alkyl; A and W are each independently phenyl or 5-6-membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; Z is hydrogen, phenyl, or 5-6-membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; each R X is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, -C OR D, -SR E, -S R D, and -S 2 R D; each R Y is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo-C 1 -C 6 alkoxy, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH,-C OR D, -S(R F) m, -S R D, -S 2 R D, and G 1; or 2 R Y groups on adjacent atoms, together with the atoms to which they are attached form a 3-7-membered fused cycloalkyl, 3-7-membered fused heterocyclyl, aryl, or 5-6 membered fused heteroaryl optionally substituted with 1-5 R X; each G 1 is independently 3-7-membered cycloalkyl, 3-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl, wherein each 3-7-membered cycloalkyl, 3-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl is optionally substituted with 1-3 R Z; each R Z is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, - C R D, -C OH, -C OR D, and -S 2 R D; R A is, at each occurrence, independently hydrogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, - C NR B R C, -C R D, -C OH, or -C OR D; each of R B and R C is independently hydrogen or C 1 -C 6 alkyl; or R B and R C together with the atom to which they are attached form a 3-7-membered heterocyclyl ring optionally substituted with 1-3 R Z; each R D is independently C 1 -C 6 alkyl or halo-C 1 -C 6 alkyl; each R E is independently hydrogen C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R F is independently hydrogen, C 1 -C 6 alkyl, or halo; and m is 1, 3, or 5. D is L 1 is CH 2 O-* or CH 2 OCH 2 -*, L 2 is selected from CH 2 O-*, CH 2 OCH 2 -*, or -O-, and "-*" indicates the attachment point to A or Z, respectively; R 1 is hydrogen or C 1 -C 6 alkyl; A and W are each independently phenyl or 5-6-membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; Z is hydrogen, phenyl, or 5-6-membered heteroaryl, wherein each phenyl or 5-6-membered heteroaryl is optionally substituted with 1-5 R Y; each R X is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH, -C OR D, -SR E, -S R D, and -S 2 R D; each R Y is independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo-C 1 -C 6 alkoxy, amino-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, oxo, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, -C R D, -C OH,-C OR D, -S(R F) m, -S R D, -S 2 R D, and G 1; or 2 R Y groups on adjacent atoms, together with the atoms to which they are attached form a 3-7-membered fused cycloalkyl, 3-7-membered fused heterocyclyl, aryl, or 5-6 membered fused heteroaryl optionally substituted with 1-5 R X; each G 1 is independently 3-7-membered cycloalkyl, 3-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl, wherein each 3-7-membered cycloalkyl, 3-7-membered heterocyclyl, aryl, or 5-6-membered heteroaryl is optionally substituted with 1-3 R Z; each R Z is independently selected from the group consisting of C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, halo, cyano, -OR A, -NR B R C, -NR B C R D, -C NR B R C, - C R D, -C OH, -C OR D, and -S 2 R D; R A is, at each occurrence, independently hydrogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, - C NR B R C, -C R D, -C OH, or -C OR D; each of R B and R C is independently hydrogen or C 1 -C 6 alkyl; or R B and R C together with the atom to which they are attached form a 3-7-membered heterocyclyl ring optionally substituted with 1-3 R Z; each R D is independently C 1 -C 6 alkyl or halo-C 1 -C 6 alkyl; each R E is independently hydrogen C 1 -C 6 alkyl, or halo-C 1 -C 6 alkyl; each R F is independently hydrogen, C 1 -C 6 alkyl, or halo; and m is 1, 3, or 5.