A collection of signature peptides representing at least 10 proteins selected from the group consisting of A1AT_HUMAN (Alpha-1-antitrypsin) A2MG_HUMAN (Alpha-2-macroglobulin) ALDOA_HUMAN (Fructose-bisphosphate aldolase A) DPP4_HUMAN (Dipeptidyl peptidase 4) EGF_HUMAN (Pro-epidermal growth factor) ITIH2_HUMAN (Inter-alpha-trypsin inhibitor heavy chain H2) LG3BP_HUMAN (Galectin-3-binding protein) PIP_HUMAN (Prolactin-inducible protein) SORL_HUMAN (Sortilin-related receptor) TRFE_HUMAN (Serotransferrin) VTDB_HUMAN (Vitamin D-binding protein) ES8L2_HUMAN (Epidermal growth factor receptor kinase substrate 8-like protein 2) HBA_HUMAN (Hemoglobin subunit alpha) HBB_HUMAN (Hemoglobin subunit beta) HPT_HUMAN (Haptoglobin) K1C17_HUMAN (Keratin, type I cytoskeletal 17) PRDX4_HUMAN (Peroxiredoxin-4) RAI3_HUMAN (Retinoic acid-induced protein 3) RAP2A_HUMAN (Ras-related protein Rap-2a) and RAP2B_HUMAN (Ras-related protein Rap-2b) for use in cancer diagnosis and/or prognosis, wherein the cancer is of a urinary tract or organ and each signature peptide represents a single protein, wherein the signature peptides are selected from the group consisting of: ITPNLAEFAFSLYR (SEQ ID NO.: 4, representing A1AT_HUMAN) LQHLENELTHDIITK (SEQ ID NO.: 5, representing A1AT_HUMAN) LSITGTYDLK (SEQ ID NO.: 6, representing A1AT_HUMAN) SVLGQLGITK (SEQ ID NO.: 8, representing A1AT_HUMAN) LVHVEEPHTETVR (SEQ ID NO.: 14, representing A2MG_HUMAN) NEDSLVFVQTDK (SEQ ID NO.: 15, representing A2MG_HUMAN) QGIPFFGQVR (SEQ ID NO.: 16, representing A2MG_HUMAN) GILAADESTGSIAK (SEQ ID NO.: 23, representing ALDOA_HUMAN) VLEDNSALDK (SEQ ID NO.: 103, representing DPP4_HUMAN) WEYYDSVYTER (SEQ ID NO.: 104, representing DPP4_HUMAN) IESSSLQGLGR (SEQ ID NO.: 105, representing EGF_HUMAN) IYWVDLER (SEQ ID NO.: 106, representing EGF_HUMAN) LFWIQYNR (SEQ ID NO.: 107, representing EGF_HUMAN) FYNQVSTPLLR (SEQ ID NO.: 156, representing ITIH2_HUMAN) IQPSGGTNINEALLR (SEQ ID NO.: 157, representing ITIH2_HUMAN) TEVNVLPGAK (SEQ ID NO.: 158, representing ITIH2_HUMAN) ELSEALGQIFDSQR (SEQ ID NO.: 184, representing LG3BP_HUMAN) SDLAVPSELALLK (SEQ ID NO.: 187, representing LG3BP_HUMAN) ELGICPDDAAVIPIK (SEQ ID NO.: 212, representing PIP_HUMAN) TFYWDFYTNR (SEQ ID NO.: 220, representing PIP_HUMAN) TVQIAAVVDVIR (SEQ ID NO.: 221, representing PIP_HUMAN) TYLISSIPLQGAFNYK (SEQ ID NO.: 222, representing PIP_HUMAN) YTACLCDDNPK (SEQ ID NO.: 223, representing PIP_HUMAN) AADLLLHSK (SEQ ID NO.: 266, representing SORL_HUMAN) TNVYISSSAGAR (SEQ ID NO.: 268, representing SORL_HUMAN) SASDLTWDNLK (SEQ ID NO.: 276, representing TRFE_HUMAN) THLPEVFLSK (SEQ ID NO.: 282, representing VTDB_HUMAN) VGPQVPLSEPGFR (SEQ ID NO.: 379, representing ES8L2_HUMAN) MFLSFPTTK (SEQ ID NO.: 393, representing HBA_HUMAN) TYFPHFDLSHGSAQVK (SEQ ID NO.: 394, representing HBA_HUMAN) VGAHAGEYGAEALER (SEQ ID NO.: 395, representing HBA_HUMAN) FLASVSTVLTSK (SEQ ID NO.: 396, representing HBA_HUMAN) SAVTALWGK (SEQ ID NO.: 398, representing HBB_HUMAN) VNVDEVGGEALGR (SEQ ID NO.: 399, representing HBB_HUMAN) EFTPPVQAAYQK (SEQ ID NO.: 400, representing HBB_HUMAN) VGYVSGWGR (SEQ ID NO.: 402, representing HPT_HUMAN) VTSIQDWVQK (SEQ ID NO.: 403, representing HPT_HUMAN) VVLHPNYSQVDIGLIK (SEQ ID NO.: 404, representing HPT_HUMAN) DYAEVGR (SEQ ID NO.: 405, representing HPT_HUMAN) VQFELHYQEVK (SEQ ID NO.: 444, representing ITIH2_HUMAN) ALEEANTELEVK (SEQ ID NO.: 451, representing K1C17_HUMAN) TIEELQNK (SEQ ID NO.: 453, representing K1C17_HUMAN) DYGVYLEDSGHTLR (SEQ ID NO.: 524, representing PRDX4_HUMAN) IPLLSDLTHQISK (SEQ ID NO.: 525, representing PRDX4_HUMAN) VSVADHSLHLSK (SEQ ID NO.: 526, representing PRDX4_HUMAN) QITLNDLPVGR (SEQ ID NO.: 528, representing PRDX4_HUMAN) AHAWPSPYK (SEQ ID NO.: 545, representing RAI3_HUMAN) TNVNVFSELSAPR (SEQ ID NO.: 546, representing RAI3_HUMAN) VPVILVGNK (SEQ ID NO.: 553, representing RAP2A_HUMAN) ASVDELFAEIVR (SEQ ID NO.: 556, representing RAP2B_HUMAN) ASNLLLGFDR (SEQ ID NO.: 575, representing SORL_HUMAN) LLGNVLVCVLAHHFGK (SEQ ID NO.: 917, representing HBB_HUMAN) and SVSCPLLSR (SEQ ID NO.: 919, representing ES8L2_HUMAN). for use in cancer diagnosis and/or prognosis, wherein the cancer is of a urinary tract or organ and each signature peptide represents a single protein, wherein the signature peptides are selected from the group consisting of: