mhurhangee/ep-ind-claims huggingface dataset:
A computer-implemented method of analyzing genomic data to identify a genomic rearrangement in a tumor cell, the method comprising: determining relative copy numbers of sequences between a tumor genomic sequence and a matched normal genomic sequence using paired-end sequence reads in a whole genome paired-end sequence analysis; identifying putative somatic breakpoints in the tumor genomic sequence and the matched normal genomic sequence, wherein each putative breakpoint is identified by a discordant pair in the paired-end sequence reads; refining the putative somatic breakpoints to identify breakpoint locations and orientations of the tumor genomic sequence, by searching for a set of unaligned reads that are anchored near the putative breakpoint by a fully-mapped mate and identifying split-reads that overlap the breakpoint junction; using a read support threshold to confirm the breakpoints as significant breakpoints, wherein the read support threshold is chosen to remove breakpoints that have read support expected of copy-neutral regions of the tumor genome; and using the relative copy numbers, the significant breakpoints, and the orientations to generate a breakpoint graph wherein the copy number is expressed as an edge and wherein the significant breakpoint position is expressed as a vertex, and determining from the graph whether a genomic arrangement has a circular solution which is indicative of a double-minute chromosome. determining relative copy numbers of sequences between a tumor genomic sequence and a matched normal genomic sequence using paired-end sequence reads in a whole genome paired-end sequence analysis; identifying putative somatic breakpoints in the tumor genomic sequence and the matched normal genomic sequence, wherein each putative breakpoint is identified by a discordant pair in the paired-end sequence reads; refining the putative somatic breakpoints to identify breakpoint locations and orientations of the tumor genomic sequence, by searching for a set of unaligned reads that are anchored near the putative breakpoint by a fully-mapped mate and identifying split-reads that overlap the breakpoint junction; using a read support threshold to confirm the breakpoints as significant breakpoints, wherein the read support threshold is chosen to remove breakpoints that have read support expected of copy-neutral regions of the tumor genome; and using the relative copy numbers, the significant breakpoints, and the orientations to generate a breakpoint graph wherein the copy number is expressed as an edge and wherein the significant breakpoint position is expressed as a vertex, and determining from the graph whether a genomic arrangement has a circular solution which is indicative of a double-minute chromosome.
A plunger assembly for a syringe, the plunger assembly comprising: an elongate plunger rod having a proximal end, a distal end, and a locking flange formed thereon between the proximal and distal ends (311, 312); and a plunger head including a cylindrical connection portion extending from a proximal wall of the plunger head, wherein the plunger rod is engageable with the plunger head such that the plunger rod is adapted to move the plunger head within a chamber of a syringe barrel through an injection cycle, wherein the distal end of the plunger rod is connected to the plunger head, characterized in that the cylindrical connecting portion of the plunger head having an annular lip at a proximal end thereof, the plunger rod has a hollow cylindrical shape defining an outer surface and an inner diameter, the inner diameter of the plunger rod having an internal annular ring adapted to engage the annular lip of the cylindrical connecting portion such that the internal annular ring of the plunger rod is able to slide over the annular lip in the distal direction and retain the annular lip of the cylindrical connecting portion within the plunger rod, and the plunger rod is slidable with respect to the cylindrical connecting portion of the plunger head such that the internal annular ring of the plunger rod engages the annular lip of the cylindrical connecting portion during aspiration and the distal end of the plunger rod engages the proximal wall of the plunger head during injection. an elongate plunger rod having a proximal end, a distal end, and a locking flange formed thereon between the proximal and distal ends (311, 312); and a plunger head including a cylindrical connection portion extending from a proximal wall of the plunger head, wherein the plunger rod is engageable with the plunger head such that the plunger rod is adapted to move the plunger head within a chamber of a syringe barrel through an injection cycle, wherein the distal end of the plunger rod is connected to the plunger head, characterized in that the cylindrical connecting portion of the plunger head having an annular lip at a proximal end thereof, the plunger rod has a hollow cylindrical shape defining an outer surface and an inner diameter, the inner diameter of the plunger rod having an internal annular ring adapted to engage the annular lip of the cylindrical connecting portion such that the internal annular ring of the plunger rod is able to slide over the annular lip in the distal direction and retain the annular lip of the cylindrical connecting portion within the plunger rod, and the plunger rod is slidable with respect to the cylindrical connecting portion of the plunger head such that the internal annular ring of the plunger rod engages the annular lip of the cylindrical connecting portion during aspiration and the distal end of the plunger rod engages the proximal wall of the plunger head during injection.
A method for the culturing of prokaryotes, yeasts and fungi in a chemically defined cell culture medium, characterized in that the cells are incubated in a cell culture medium comprising 0.01 to 10 g/L glutamine, 0.01 to 3 g/L cysteine and/or cystine, 0.1 to 300 mg/L adenine, 0.01 to 100 mg/L guanine, 0.01 to 10 g/L aminobenzoic acid, nicotinamide adenine dinucleotide and 0.01 to 100 mg/L of an iron salt.
A tube for temporary affixment to a mouthpiece of a smoking article, the tube comprising: an open upstream end; an open downstream end; an outer surface; and an inner surface defining a lumen for receiving the mouthpiece of the smoking article, the lumen extending from the open upstream end to the open downstream end, wherein the tube further comprises: a first ventilation zone for providing ventilation into the lumen of the tube, the first ventilation zone comprising a first line of perforation holes extending from the outer surface to the inner surface and circumscribing the tube at a location at least 10mm from the open downstream end of the tube, characterized in that the tube further comprises a second ventilation zone for providing ventilation into the lumen of the tube, the second ventilation zone comprising a first line of perforation holes circumscribing the tube at a location between 10mm and 15mm from the open upstream end of the tube, wherein the first line of perforation holes of the first ventilation zone is configured to provide a different level of ventilation than the first line of perforation holes of the second ventilation zone. an open upstream end; an open downstream end; an outer surface; and an inner surface defining a lumen for receiving the mouthpiece of the smoking article, the lumen extending from the open upstream end to the open downstream end, wherein the tube further comprises: a first ventilation zone for providing ventilation into the lumen of the tube, the first ventilation zone comprising a first line of perforation holes extending from the outer surface to the inner surface and circumscribing the tube at a location at least 10mm from the open downstream end of the tube, characterized in that the tube further comprises a second ventilation zone for providing ventilation into the lumen of the tube, the second ventilation zone comprising a first line of perforation holes circumscribing the tube at a location between 10mm and 15mm from the open upstream end of the tube, wherein the first line of perforation holes of the first ventilation zone is configured to provide a different level of ventilation than the first line of perforation holes of the second ventilation zone. a first ventilation zone for providing ventilation into the lumen of the tube, the first ventilation zone comprising a first line of perforation holes extending from the outer surface to the inner surface and circumscribing the tube at a location at least 10mm from the open downstream end of the tube, characterized in that the tube further comprises a second ventilation zone for providing ventilation into the lumen of the tube, the second ventilation zone comprising a first line of perforation holes circumscribing the tube at a location between 10mm and 15mm from the open upstream end of the tube, wherein the first line of perforation holes of the first ventilation zone is configured to provide a different level of ventilation than the first line of perforation holes of the second ventilation zone.
A display device comprising; an external housing (1, 2, 4); and a display module accepted into the external housing (1, 2, 4); wherein the external housing (1, 2,4) including a regular reflection unit regularly reflecting lights from outside and a diffused reflection unit diffusely reflecting lights from outside, and characterized in that the diffused reflection unit is formed as protruded for a fixed height difference upwardly as compared to the regular reflection unit, the height difference being of 1 to 100 micrometer, and wherein the diffused reflection unit is rough and the surface of the diffused reflection unit is formed in a shape of a predetermined pattern composed of hollows and ridges of waveforms different from each other, wherein the regular reflection unit and the diffused reflection unit are mixed on the external housing (1, 2, 4), and the roughness of the regular reflection unit and the diffused reflection unit are different from each other, wherein the contrast gloss is controlled in accordance with controlling the area of the regular reflection unit and the diffused reflection unit.
Haptic interface comprising: - an element for interacting with a user and capable of moving in a first direction and in a second direction, - an element for interacting with a fluid whose viscosity varies according to an external stimulus, the fluid-interaction element being rigidly connected to the user-interaction element at least for translation therewith or at least for rotation therewith, - means for measuring a current angular position of the user-interaction element, - means for determining the direction of rotation of the user-interaction element, - a brake comprising a fluid whose apparent viscosity varies according to an external stimulus and a system for generating said stimulus on command in said fluid, the fluid-interaction element being disposed in the fluid, - rotary electromechanical means comprising a shaft rigidly connected to the user-interaction element for rotation therewith, - a control unit capable of generating commands for said system for generating said stimulus to modify the value of the stimulus, and to the rotary electromechanical means, the haptic interface being characterised in that it comprises - means for detecting the torque exerted by a user on the user-interaction element, in the case of a rotatable user-interaction element, in order to determine the direction of the torque and if the torque is greater than a given value for a given direction, the control unit controlling the generation system of said stimulus based on the information obtained on the torque at least when a velocity of the user-interaction element of zero is detected. - an element for interacting with a user and capable of moving in a first direction and in a second direction, - an element for interacting with a fluid whose viscosity varies according to an external stimulus, the fluid-interaction element being rigidly connected to the user-interaction element at least for translation therewith or at least for rotation therewith, - means for measuring a current angular position of the user-interaction element, - means for determining the direction of rotation of the user-interaction element, - a brake comprising a fluid whose apparent viscosity varies according to an external stimulus and a system for generating said stimulus on command in said fluid, the fluid-interaction element being disposed in the fluid, - rotary electromechanical means comprising a shaft rigidly connected to the user-interaction element for rotation therewith, - a control unit capable of generating commands for said system for generating said stimulus to modify the value of the stimulus, and to the rotary electromechanical means, the haptic interface being characterised in that it comprises - means for detecting the torque exerted by a user on the user-interaction element, in the case of a rotatable user-interaction element, in order to determine the direction of the torque and if the torque is greater than a given value for a given direction, the control unit controlling the generation system of said stimulus based on the information obtained on the torque at least when a velocity of the user-interaction element of zero is detected.
A method of operating one or more electronic processors to diagnose the presence of a malady of the respiratory system of a patient comprising: accessing with said processors a digital audio signal of sounds of the patient in an electronic storage assembly; identifying a number of epochs of the digital audio signal; identifying a plurality of sub-segments for each of the epochs; for each sub-segment of each of the epochs determining an associated multiplicity of mel-frequency cepstral coefficients, MFCCs; determining deviation scores from a probability distribution for each of the epochs in respect of each of the multiplicity of MFCCs; forming a test vector for the patient based upon the deviations scores from the probability distribution of the MFCCs; applying the test vector to a pre-trained decision machine stored in said electronic storage assembly to thereby generate a malady signal indicating malady or non-malady for the patient; and controlling a display responsive to the one or more electronic processors to display a message corresponding to the malady signal. accessing with said processors a digital audio signal of sounds of the patient in an electronic storage assembly; identifying a number of epochs of the digital audio signal; identifying a plurality of sub-segments for each of the epochs; for each sub-segment of each of the epochs determining an associated multiplicity of mel-frequency cepstral coefficients, MFCCs; determining deviation scores from a probability distribution for each of the epochs in respect of each of the multiplicity of MFCCs; forming a test vector for the patient based upon the deviations scores from the probability distribution of the MFCCs; applying the test vector to a pre-trained decision machine stored in said electronic storage assembly to thereby generate a malady signal indicating malady or non-malady for the patient; and controlling a display responsive to the one or more electronic processors to display a message corresponding to the malady signal.
Device for identifying a prostate tumor, comprising a Raman spectroscopy system for acquiring at least one Raman spectrum (36-39; 40; 44; 45) of a tissue sample, and an electronic evaluation unit set up to identify the prostate tumor based on an evaluation of the at least one Raman spectrum (36-29; 40; 44; 45), wherein the device is set up to acquiring at least one Raman spectrum (36-39; 40; 44; 45) at a plurality of positions of the tissue sample, and wherein the electronic evaluation unit is set up to evaluate the Raman spectra (36-39; 40; 44; 45) acquired at the plurality of positions to determine a gradient field using the evaluation of the Raman spectra (36-39; 40; 44; 45) acquired at the plurality of positions to determine a position of the prostate tumor in the tissue sample or relative to the tissue sample, wherein the gradient field for the Raman spectra (36-39; 40; 44; 45), acquired at the plurality of positions, indicates how strongly and in which direction an intensity of a Raman peak or several Raman peaks changes, wherein the electronic evaluation unit is set up to determine whether an aggressive or non-aggressive prostate tumor is present using a statistical evaluation of the Raman spectra (36-39; 40; 44; 45) acquired at the plurality of positions.
Floor washing-drying machine comprising a motor for driving a rotating shaft of one or more brushes adapted to scrub a washing liquid onto a floor, a head including said brushes, a scraping device to scrape said liquid after washing, said scraping device being mounted with respect to said rotating shaft in neutral, at an axial distance from said one or more brushes and it is maintained behind said one or more brushes due to friction onto the floor, during forward and steering movements of the machine, characterized in that when the head is lifted up from the floor, due to gravity said axial distance between one or more brushes and scraping device becomes zero and the scraping device is engaged by means of rotation of said one or more brushes to be positioned always behind the brushes, during backwards movement, through a friction-engaging element.
A one-component water-reducing composition, being an admixture for addition to a hydraulic composition and comprising a mixture of - a thickener comprising water-soluble cellulose ether, defoamer, and gum, with - water-reducing agent and wherein - the amount of the water-soluble cellulose ether is 0.01 to 20% by weight based on the water-reducing agent; - the amount of the defoamer is 0.001 to 16% by weight based on the water-reducing agent, and - the amount of the gum, which is selected from diutan gum, welan gum, xanthan gum and gellan gum, is in the case of diutan gum, 0.005 to 2% by weight based on the water-reducing agent and, in the case of welan gum, xanthan gum or gellan gum, 0.01 to 20% by weight based on the water-reducing agent. - a thickener comprising water-soluble cellulose ether, defoamer, and gum, with - water-reducing agent - the amount of the water-soluble cellulose ether is 0.01 to 20% by weight based on the water-reducing agent; - the amount of the defoamer is 0.001 to 16% by weight based on the water-reducing agent, and - the amount of the gum, which is selected from diutan gum, welan gum, xanthan gum and gellan gum, is in the case of diutan gum, 0.005 to 2% by weight based on the water-reducing agent and, in the case of welan gum, xanthan gum or gellan gum, 0.01 to 20% by weight based on the water-reducing agent.
An electrically conductive compressible bushing system for carbon fiber reinforced polymer CFRPstructures comprising: a CFRP structural element having a feedthrough hole; an externally threaded feedthrough, having a diameter, to be received in the hole; a bushing received within the hole intermediate the hole and feedthrough, said bushing having a compressed length with expanded inner and outer diameter, said expanded inner and outer diameter contacting the hole and feedthrough for electrical conductivity; and, a nut received on the external threads of the feedthrough, said nut tightened to urge the bushing to the compressed length; characterised in that the bushing incorporates at least one accordion pleat intermediate opposite end portions, said accordion pleat expanding diametrically upon compression of the end portions by the nut. a CFRP structural element having a feedthrough hole; an externally threaded feedthrough, having a diameter, to be received in the hole; a bushing received within the hole intermediate the hole and feedthrough, said bushing having a compressed length with expanded inner and outer diameter, said expanded inner and outer diameter contacting the hole and feedthrough for electrical conductivity; and, a nut received on the external threads of the feedthrough, said nut tightened to urge the bushing to the compressed length; characterised in that the bushing incorporates at least one accordion pleat intermediate opposite end portions, said accordion pleat expanding diametrically upon compression of the end portions by the nut.
A solid-state imaging device comprising: a photodetecting section having M x N pixels (each of M and N being an integer of 2 or more), each including one photodiode and first and second switch circuits (21, 22) each having one terminal connected to the one photodiode, two-dimensionally arrayed in M rows and N columns; N readout lines provided for the respective columns and connected to the other terminals of the first and second switch circuits included in the pixels of the corresponding columns; M first row selection lines provided for the respective rows and connected to control terminals of the first switch circuits included in the pixels of the corresponding rows; M first buffers having respective output terminals connected to the M first row selection lines; M second row selection lines provided for the respective rows and connected to control terminals of the second switch circuits included in the pixels of the corresponding rows; M second buffers having respective output terminals connected to the M second row selection lines; and a shift register section for generating a row selection signal for controlling an open/closed state of the first and second switch circuits for each row and providing input terminals of the first and second buffers with the common row selection signal, wherein the shift register section has M signal output terminals provided one by one for the respective rows for outputting the row selection signal, the signal output terminals being connected to the input terminals of the first and second buffers of the corresponding rows. a photodetecting section having M x N pixels (each of M and N being an integer of 2 or more), each including one photodiode and first and second switch circuits (21, 22) each having one terminal connected to the one photodiode, two-dimensionally arrayed in M rows and N columns; N readout lines provided for the respective columns and connected to the other terminals of the first and second switch circuits included in the pixels of the corresponding columns; M first row selection lines provided for the respective rows and connected to control terminals of the first switch circuits included in the pixels of the corresponding rows; M first buffers having respective output terminals connected to the M first row selection lines; M second row selection lines provided for the respective rows and connected to control terminals of the second switch circuits included in the pixels of the corresponding rows; M second buffers having respective output terminals connected to the M second row selection lines; and a shift register section for generating a row selection signal for controlling an open/closed state of the first and second switch circuits for each row and providing input terminals of the first and second buffers with the common row selection signal, wherein the shift register section has M signal output terminals provided one by one for the respective rows for outputting the row selection signal, the signal output terminals being connected to the input terminals of the first and second buffers of the corresponding rows.