A cryotherapeutic device (120, 620), comprising: an elongated shaft having a distal portion (126, 626) wherein the shaft is configured to locate the distal portion intravascularly at a treatment site in or otherwise proximate a renal artery or renal ostium; a supply lumen housed within at least a portion of the shaft and configured to transport refrigerant along the shaft to the distal portion, the supply lumen having a terminal opening through which refrigerant can flow from the supply lumen into the distal portion; a cooling assembly (130, 630) at the distal portion of the shaft, the cooling assembly having a delivery state and a deployed state, and the cooling assembly including - an applicator having an expansion chamber wherein the distal portion extends axially through the expansion chamber, and a distributor positioned at a distal end of the cooling assembly, wherein the distributor is in fluid communication with the terminal opening, and wherein the distributor includes a plurality of first orifices radially spaced apart from one another around the shaft and through which refrigerant can flow from the terminal opening into the expansion chamber; an exhaust path extending from the expansion chamber along at least a portion of the shaft, the exhaust path including a plurality of second orifices proximate the first orifices and radially spaced apart from one another around the shaft and through which refrigerant can flow from the expansion chamber; and an internal barrier configured to seal the shaft at a position intermediate the terminal opening and the plurality of second orifices, wherein the plurality of first orifices are radially off-set from the plurality of second orifices. an elongated shaft having a distal portion (126, 626) wherein the shaft is configured to locate the distal portion intravascularly at a treatment site in or otherwise proximate a renal artery or renal ostium; a supply lumen housed within at least a portion of the shaft and configured to transport refrigerant along the shaft to the distal portion, the supply lumen having a terminal opening through which refrigerant can flow from the supply lumen into the distal portion; a cooling assembly (130, 630) at the distal portion of the shaft, the cooling assembly having a delivery state and a deployed state, and the cooling assembly including - an applicator having an expansion chamber wherein the distal portion extends axially through the expansion chamber, and a distributor positioned at a distal end of the cooling assembly, wherein the distributor is in fluid communication with the terminal opening, and wherein the distributor includes a plurality of first orifices radially spaced apart from one another around the shaft and through which refrigerant can flow from the terminal opening into the expansion chamber; an applicator having an expansion chamber wherein the distal portion extends axially through the expansion chamber, and a distributor positioned at a distal end of the cooling assembly, wherein the distributor is in fluid communication with the terminal opening, and wherein the distributor includes a plurality of first orifices radially spaced apart from one another around the shaft and through which refrigerant can flow from the terminal opening into the expansion chamber; an exhaust path extending from the expansion chamber along at least a portion of the shaft, the exhaust path including a plurality of second orifices proximate the first orifices and radially spaced apart from one another around the shaft and through which refrigerant can flow from the expansion chamber; and an internal barrier configured to seal the shaft at a position intermediate the terminal opening and the plurality of second orifices, wherein the plurality of first orifices are radially off-set from the plurality of second orifices.