mhurhangee/ep-ind-claims huggingface dataset:
A method of producing a plurality of modified polynucleotides having different combinations of various mutations at multiple sites, wherein the mutations are changes to one or more nucleotides in the sequence of a parental nucleic acid sequence, said method comprising: (a) adding at least three primers to a double stranded template polynucleotide in a single reaction mixture, wherein the at least three primers are not overlapping, and wherein each of the at least three primers comprise at least one mutation different from the other primers, wherein at least one primer is a forward primer that can anneal to a minus strand of the template and at least one primer is a reverse primer that can anneal to a plus strand of the template, and (b) subjecting the reaction mixture to a polymerase extension reaction to yield a plurality of extended modified polynucleotides from the at least three primers. (a) adding at least three primers to a double stranded template polynucleotide in a single reaction mixture, wherein the at least three primers are not overlapping, and wherein each of the at least three primers comprise at least one mutation different from the other primers, wherein at least one primer is a forward primer that can anneal to a minus strand of the template and at least one primer is a reverse primer that can anneal to a plus strand of the template, and (b) subjecting the reaction mixture to a polymerase extension reaction to yield a plurality of extended modified polynucleotides from the at least three primers.
A flow sensing device (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000), comprising: a flow cap component (101, 204, 303, 404, 503, 602, 701) comprising a heating element (105, 107, 606, 626, 707, 709, 802, 804, 901, 903, 1010, 1012) disposed in a first layer (109, 622, 717) of the flow cap component; and a sensor component (103, 202, 301, 402, 501, 604, 703) comprising: at least one thermal sensing element (111, 113, 608, 610, 711, 713, 808, 808, 810, 905, 907, 909, 1002, 1004) disposed in a second layer (115, 624, 719) of the sensor component, wherein the flow cap component is bonded to a first surface of the sensor component to form a flow channel (125, 507, 613, 715), wherein the first layer and the second layer are noncoplanar and separated by the flow channel; characterized in that the sensor component is further comprising at least one plate element (812, 814, 816, 911, 913, 915, 1006, 1008) disposed on a third layer of the sensor component, wherein the at least one plate element at least partially overlaps with the at least one thermal sensing element. a flow cap component (101, 204, 303, 404, 503, 602, 701) comprising a heating element (105, 107, 606, 626, 707, 709, 802, 804, 901, 903, 1010, 1012) disposed in a first layer (109, 622, 717) of the flow cap component; and a sensor component (103, 202, 301, 402, 501, 604, 703) comprising: at least one thermal sensing element (111, 113, 608, 610, 711, 713, 808, 808, 810, 905, 907, 909, 1002, 1004) disposed in a second layer (115, 624, 719) of the sensor component, wherein the flow cap component is bonded to a first surface of the sensor component to form a flow channel (125, 507, 613, 715), wherein the first layer and the second layer are noncoplanar and separated by the flow channel; characterized in that the sensor component is further comprising at least one plate element (812, 814, 816, 911, 913, 915, 1006, 1008) disposed on a third layer of the sensor component, wherein the at least one plate element at least partially overlaps with the at least one thermal sensing element. at least one thermal sensing element (111, 113, 608, 610, 711, 713, 808, 808, 810, 905, 907, 909, 1002, 1004) disposed in a second layer (115, 624, 719) of the sensor component, wherein the flow cap component is bonded to a first surface of the sensor component to form a flow channel (125, 507, 613, 715), wherein the first layer and the second layer are noncoplanar and separated by the flow channel; characterized in that the sensor component is further comprising at least one plate element (812, 814, 816, 911, 913, 915, 1006, 1008) disposed on a third layer of the sensor component, wherein the at least one plate element at least partially overlaps with the at least one thermal sensing element.
A toner for electrophotography comprising toner base particles and an external additive adhered on the surfaces of the toner base particles, characterised in that the toner base particles are obtainable by: dissolving and/or dispersing at least a polyester prepolymer having an isocyanate group capable of reacting with an active hydrogen group-containing compound and a colorant in an organic solvent, further dispersing the solution or the dispersion liquid in an aqueous medium to subject the polyester prepolymer having an isocyanate group capable of reacting with the active hydrogen-containing compound to an elongation and/or a cross-linking reaction, and removing the organic solvent from the obtained dispersion liquid to thereby obtain toner base particles comprising a toner binder and a colorant, which toner base particles comprise one or more inorganic fine particles contained therein, the toner base particles further comprising a releasing agent, wherein the total amount of the inorganic fine particles determined by fluorescent x-ray spectroscopy is 0.5% by weight to 50% by weight, and wherein the element concentration derived from the inorganic fine particles on the surfaces of the toner base particles determined by x-ray photoelectron spectroscopy is 0.1 atomic% to 15 atomic%. dissolving and/or dispersing at least a polyester prepolymer having an isocyanate group capable of reacting with an active hydrogen group-containing compound and a colorant in an organic solvent, further dispersing the solution or the dispersion liquid in an aqueous medium to subject the polyester prepolymer having an isocyanate group capable of reacting with the active hydrogen-containing compound to an elongation and/or a cross-linking reaction, and removing the organic solvent from the obtained dispersion liquid to thereby obtain toner base particles comprising a toner binder and a colorant, which toner base particles comprise one or more inorganic fine particles contained therein, the toner base particles further comprising a releasing agent, wherein the total amount of the inorganic fine particles determined by fluorescent x-ray spectroscopy is 0.5% by weight to 50% by weight, and wherein the element concentration derived from the inorganic fine particles on the surfaces of the toner base particles determined by x-ray photoelectron spectroscopy is 0.1 atomic% to 15 atomic%.
Valve for reciprocating compressors, the valve comprising: - a valve seat with first gas flow passages extending through said valve seat; - a valve guard having second gas flow passages extending through said valve guard; - at least one shutter ring arranged between said valve guard and said valve seat, the shutter ring being configured to move between a closed position in which the passage of fluid is prevented and an open position in which the passage of fluid is allowed, wherein said at least one shutter ring is resiliently biased by resilient members against the valve seat to close said first gas flow passages, wherein the valve seat and the valve guard are relatively movable to define a variable gap or lift for the shutter ring and characterized in that the valve further comprises an actuator (32, 2. 34, 42, 43) to adjust the relative position of the valve seat and the valve guard. - a valve seat with first gas flow passages extending through said valve seat; - a valve guard having second gas flow passages extending through said valve guard; - at least one shutter ring arranged between said valve guard and said valve seat, the shutter ring being configured to move between a closed position in which the passage of fluid is prevented and an open position in which the passage of fluid is allowed,
A polymeric fibre derived from a copolymer of polyacrylonitrile and a comonomer, said fibre comprising a metal ion and/or silicon at from about 1 to about 15 wt% and said fibre having no detectable crystallinity as measured using x-ray scattering, wherein the copolymer comprises from about 10 to about 30 mol% of the comonomer; characterised in that the comonomer is an acrylic or methacrylic comonomer; and the copolymer is not a block copolymer.
Device for wetting multiple threads with a fluid, having multiple wetting means (1.1 - 1.6) assigned to the threads and having a dosing pump which is connected to the wetting means (1.1 - 1.6) by multiple conveying lines (5.1 - 5.6), wherein the dosing pump has multiple conveying means (8.1) for generating multiple dosing flows of the fluid and has multiple pump outlets (7.1 - 7.6), to which the conveying lines (5.1 - 5.6) are connected, and wherein the conveying means are formed by at least one planetary gear set (8.1) arranged between housing plates (12.1, 12.2), characterized in that multiple planet gears (9.1 - 9.6) of the planetary gear set (8.1) are guided freely by a centering plate (11.1) between adjacent housing plates (12.1, 12.2), in that the planet gears (9.1 - 9.6) of the planetary gear set (8.1 - 8.3) have in each case one passage opening, and in that the passage openings of the planet gears (9.1, 9.2) are connected by a channel system to at least one pump inlet.
A DC electrical system comprising a plurality of earthing arrangements (22A, 22B, 22C), each earthing arrangement (22A, 22B, 22C) comprising: an earthing point (24A, 24B, 24C); a solid connection (30A, 30B, 30C) from the earthing point (24A, 24B, 24C) to earth, a high impedance connection (28A, 28B, 28C) from the earthing point (24A, 24B, 24C) to earth, and a switch (32A, 32B, 32C) arranged to connect the earthing point (24A, 24B, 24C) to earth by its high impedance connection (28A, 28B, 28C) or to connect the earthing point (24A, 24B, 24C) to earth by its solid connection (30A, 30B, 30C), wherein the DC electrical system further comprises a controller configured to control the opening and closing of the switches (32A, 32B, 32C) so that, during normal operation of the DC electrical system, only one of the switches (32A, 32B, 32C) is closed so that only one of the earthing points (24A, 24B, 24C) is connected to earth by its solid connection (30A, 30B, 30C). an earthing point (24A, 24B, 24C); a solid connection (30A, 30B, 30C) from the earthing point (24A, 24B, 24C) to earth, a high impedance connection (28A, 28B, 28C) from the earthing point (24A, 24B, 24C) to earth, and a switch (32A, 32B, 32C) arranged to connect the earthing point (24A, 24B, 24C) to earth by its high impedance connection (28A, 28B, 28C) or to connect the earthing point (24A, 24B, 24C) to earth by its solid connection (30A, 30B, 30C), wherein the DC electrical system further comprises a controller configured to control the opening and closing of the switches (32A, 32B, 32C) so that, during normal operation of the DC electrical system, only one of the switches (32A, 32B, 32C) is closed so that only one of the earthing points (24A, 24B, 24C) is connected to earth by its solid connection (30A, 30B, 30C).
A system with an elongated body having at least one lumen, an optical fiber extending through the at least one lumen for discharge of a laser energy, and a distal end, the distal end comprising: a port that permits discharge of a laser energy towards a tissue from the optical fiber located in the distal end; an exterior surface including a cauterization portion that permits discharge of a cauterization energy towards the tissue; and an insulative portion that attaches the distal end to the elongated body and limits energy transfer therebetween; wherein the cauterization energy is a thermal energy, and the laser energy is dischargeable towards the cauterization portion to generate the thermal energy; and wherein the optical fiber is mounted in the elongated body for movement between a first position, wherein the laser energy is dischargeable through the port towards the tissue, to a second position, wherein the laser energy is dischargeable towards an interior surface of cauterization portion. a port that permits discharge of a laser energy towards a tissue from the optical fiber located in the distal end; an exterior surface including a cauterization portion that permits discharge of a cauterization energy towards the tissue; and an insulative portion that attaches the distal end to the elongated body and limits energy transfer therebetween; wherein the cauterization energy is a thermal energy, and the laser energy is dischargeable towards the cauterization portion to generate the thermal energy; and wherein the optical fiber is mounted in the elongated body for movement between a first position, wherein the laser energy is dischargeable through the port towards the tissue, to a second position, wherein the laser energy is dischargeable towards an interior surface of cauterization portion.
Apparatus for use in a lighting system, the apparatus comprising: a device location module configured to determine device location information relating to a location of a wireless user device (14, 14') within a spatial region associated with the lighting system; and a user location module configured to determine user location information indicative of whether a user is accompanying the wireless user device in said spatial region; and characterized in that the apparatus further comprises: an access module configured to allow the wireless user device (14, 14') to control the lighting system in dependence on a plurality of access rules, the access rules comprising at least that: (i) allowance is conditional on the wireless user device being determined, based on said device location information, to be within said spatial region associated with the lighting system, and (ii) said allowance is withheld in response to determining that said user location information is indicative of the wireless user device being unaccompanied by a user. a device location module configured to determine device location information relating to a location of a wireless user device (14, 14') within a spatial region associated with the lighting system; and a user location module configured to determine user location information indicative of whether a user is accompanying the wireless user device in said spatial region; and characterized in that the apparatus further comprises: an access module configured to allow the wireless user device (14, 14') to control the lighting system in dependence on a plurality of access rules, the access rules comprising at least that: (i) allowance is conditional on the wireless user device being determined, based on said device location information, to be within said spatial region associated with the lighting system, and (ii) said allowance is withheld in response to determining that said user location information is indicative of the wireless user device being unaccompanied by a user.
Leaf (1, 101) for mitre gate, the leaf (1, 101) comprising: - skin plate intended to support a pressure exerted by a liquid, and - at least two uprights (4, 6) located respectively on either side (24, 26) of the skin plate, the uprights (4, 6) being secured to the skin plate, the skin plate being in the overall shape of a cylinder portion, the longitudinal axis of the cylinder being essentially parallel to the uprights (4, 6), each upright (4, 6) extending overall according to a generatrix (Z24, Z26) of the cylinder, each upright (4, 6) including at least one bearing element (40, 60), arranged to project relative to the skin plate, and each bearing element (40, 60) including a bearing surface (42, 62), for supporting the bearing element (40, 60) against a lock wall or against another leaf (1, 101) of the mitre gate, the leaf (1, 101) being characterised in that the bearing surface (42, 62) of each bearing element (40, 60) is aligned with a plane (P4, P6) that is tangential to the skin plate, at the side (24, 26) of the skin plate corresponding to said bearing element (40, 60), and being cut by said plane (P4, P6) and perpendicular to it. - skin plate intended to support a pressure exerted by a liquid, and - at least two uprights (4, 6) located respectively on either side (24, 26) of the skin plate, the uprights (4, 6) being secured to the skin plate,
Friction ring-type transmission for a vehicle operable by motor power and/or pedal power, in particular for an electric bicycle with an electric motor, comprising: - a crankshaft for pedal cranks (102, 103), and - an inner friction ring and an outer friction ring and at least one rotatable double conical roller which is arranged on a roller carrier and which is in frictional engagement with the inner friction ring and the outer friction ring, characterized in that - the friction ring-type transmission is arranged coaxially around the crankshaft, wherein - the friction ring-type transmission has a housing which at least partially surrounds the friction ring-type transmission and which does not revolve during the operation of the friction ring-type transmission, wherein - the friction ring-type transmission has, for its transmission ratio, an adjusting device which is movable substantially along an at least approximately straight adjustment path running in the housing, by means of which adjusting device the roller carrier is axially displaceable in relation to the friction rings (20, 26), wherein the adjusting device runs through the housing and has no adjusting thread, wherein - the adjusting device runs non-coaxially with respect to the friction ring-type transmission. - a crankshaft for pedal cranks (102, 103), and - an inner friction ring and an outer friction ring and at least one rotatable double conical roller which is arranged on a roller carrier and which is in frictional engagement with the inner friction ring and the outer friction ring, - the friction ring-type transmission is arranged coaxially around the crankshaft, wherein - the friction ring-type transmission has a housing which at least partially surrounds the friction ring-type transmission and which does not revolve during the operation of the friction ring-type transmission, wherein - the friction ring-type transmission has, for its transmission ratio, an adjusting device which is movable substantially along an at least approximately straight adjustment path running in the housing, by means of which adjusting device the roller carrier is axially displaceable in relation to the friction rings (20, 26), wherein the adjusting device runs through the housing and has no adjusting thread, wherein - the adjusting device runs non-coaxially with respect to the friction ring-type transmission.
A device for holding an arrangement, the arrangement comprising a suprastructure and an abutment, and having a clamping device for the arrangement, the clamping device being adjustable in height in relation to an auxiliary device connected to the clamping device, the abutment and/or the suprastructure, characterized in that, in the region of the auxiliary device, depressions (50, 51) are provided in which occlusal projections such as cusps or cutting edges of the suprastructure can enter, and via which depressions (50, 51) centering is effected, and the arrangement can be held clamped between the auxiliary device and the clamping device, and in that part of the suprastructure, namely an occlusal and/or incisal surface of the suprastructure, is receivable in the auxiliary device.
Power converter having a series circuit comprising a multiplicity of modules (1_1, 1_2, 1_3,...) that each have at least two electronic switching elements (202, 206) and an electrical capacitor, wherein the electrical capacitor has a dielectric, characterized in that the dielectric has a film that is provided with a glass-ceramic layer, wherein - the glass-ceramic layer has a thickness of between 1 nm and 10 nm, and - the film is a plastic film. - the glass-ceramic layer has a thickness of between 1 nm and 10 nm, and - the film is a plastic film.
A method for wireless communications, comprising: receiving a message during a first symbol period (330, 340) according to a first timing configuration (305, 311), wherein the message comprises one of a data message (330, 405) or a scheduling request, SR (340, 430); decoding the message during a decoding time period (335, 351) that is shorter than the first symbol period; and transmitting a response to the received message based at least in part on the decoding, the response transmitted during a second symbol period (326, 324) according to a second timing configuration (310, 306), wherein the second timing configuration is staggered relative to the first timing configuration according to a predetermined offset that is half the length of the first symbol period, and wherein the response comprises one of a hybrid automatic repeat request, HARQ, feedback message (326, 415) or an uplink, UL, grant (324, 440). receiving a message during a first symbol period (330, 340) according to a first timing configuration (305, 311), wherein the message comprises one of a data message (330, 405) or a scheduling request, SR (340, 430); decoding the message during a decoding time period (335, 351) that is shorter than the first symbol period; and transmitting a response to the received message based at least in part on the decoding, the response transmitted during a second symbol period (326, 324) according to a second timing configuration (310, 306), wherein the second timing configuration is staggered relative to the first timing configuration according to a predetermined offset that is half the length of the first symbol period, and wherein the response comprises one of a hybrid automatic repeat request, HARQ, feedback message (326, 415) or an uplink, UL, grant (324, 440).