A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is independently selected from: C 1 -C 6 alkyl substituted with one to two R a, C 2 -C 6 alkenyl substituted with one to two R a, - n -(C 3 -C 6 cycloalkyl substituted with one to two R d), - n -(phenyl substituted with zero to three R b), - n -(6-membered heteroaryl comprising carbon atoms and 1-2 heteroatoms selected from N and NR a, where said heteroaryl is substituted with zero to three R b), R 2 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 3 is independently selected from: and R 4 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 5 is independently selected from: H, halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl and C 3 -C 6 cycloalkyl; R 6 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 7 is, at each occurrence, independently selected from: NH 2, NH(C 1 -C 4 alkyl), and NHCO(C 1 -C 4 alkyl); R 8 is, at each occurrence, independently selected from: H, halogen, C 1 -C 4 alkyl, and C 1 -C 4 haloalkyl; Y is, at each occurrence, independently selected from: CH and N; W is independently selected from: O and NH; R a is independently selected from: OH, C 1 -C 4 alkoxy, CO 2 (C 1 -C 4 alkyl), CONR e R f, and NHR e; R b is independently selected from: halogen, C 1 -C 4 haloalkoxy, OH, CN, CO 2 (C 1 -C 4 alkyl), CONR e R f, NHR e C 1 -C 4 alkyl substituted with zero to one R c, and C 1 -C 4 alkoxy substituted with zero to one R c; R c is independently selected from: OH, C 1 -C 4 alkoxy, CO 2 (C 1 -C 4 alkyl), CONR e R f, and NHR e; R d is independently selected from: OH, =O, and NH(C 1 -C 4 alkyl); R e is independently selected from: H, C 1 -C 4 alkyl, and CO(C 1 -C 4 alkyl); R f is independently selected from: H and C 1 -C 4 alkyl; m is independently selected from: 1 and 2; n, at each occurrence, is independently selected from: 0 and 1; and q is independently selected from: 1, 2 and 3. R 1 is independently selected from: C 1 -C 6 alkyl substituted with one to two R a, C 2 -C 6 alkenyl substituted with one to two R a, - n -(C 3 -C 6 cycloalkyl substituted with one to two R d), - n -(phenyl substituted with zero to three R b), - n -(6-membered heteroaryl comprising carbon atoms and 1-2 heteroatoms selected from N and NR a, where said heteroaryl is substituted with zero to three R b), R 2 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 3 is independently selected from: and R 4 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 5 is independently selected from: H, halogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl and C 3 -C 6 cycloalkyl; R 6 is independently selected from: H, halogen and C 1 -C 4 alkyl; R 7 is, at each occurrence, independently selected from: NH 2, NH(C 1 -C 4 alkyl), and NHCO(C 1 -C 4 alkyl); R 8 is, at each occurrence, independently selected from: H, halogen, C 1 -C 4 alkyl, and C 1 -C 4 haloalkyl; Y is, at each occurrence, independently selected from: CH and N; W is independently selected from: O and NH; R a is independently selected from: OH, C 1 -C 4 alkoxy, CO 2 (C 1 -C 4 alkyl), CONR e R f, and NHR e; R b is independently selected from: halogen, C 1 -C 4 haloalkoxy, OH, CN, CO 2 (C 1 -C 4 alkyl), CONR e R f, NHR e C 1 -C 4 alkyl substituted with zero to one R c, and C 1 -C 4 alkoxy substituted with zero to one R c; R c is independently selected from: OH, C 1 -C 4 alkoxy, CO 2 (C 1 -C 4 alkyl), CONR e R f, and NHR e; R d is independently selected from: OH, =O, and NH(C 1 -C 4 alkyl); R e is independently selected from: H, C 1 -C 4 alkyl, and CO(C 1 -C 4 alkyl); R f is independently selected from: H and C 1 -C 4 alkyl; m is independently selected from: 1 and 2; n, at each occurrence, is independently selected from: 0 and 1; and q is independently selected from: 1, 2 and 3.