mhurhangee/ep-ind-claims huggingface dataset:
A method for identifying a target site of a nuclease, the method comprising: (a) providing a nuclease that cuts a nucleic acid target site, wherein cutting of the target site results in a cut end; (b) contacting the nuclease of step (a) with a library of candidate nucleic acid molecules, wherein each nucleic acid molecule comprises a concatemer of a sequence comprising a candidate nuclease target site and a constant insert sequence of at least 10 and not more than 95 nucleotides, under conditions suitable for the nuclease to cut a candidate nucleic acid molecule comprising a target site of the nuclease; and (c) ligating a nucleic acid adapter onto the cut end of the candidate nucleic acid molecule; and (d) directly sequencing from the nucleic acid adapter in a single read-through an uncut target site adjacent the cut end, thereby identifying the target site of the nuclease. (a) providing a nuclease that cuts a nucleic acid target site, wherein cutting of the target site results in a cut end; (b) contacting the nuclease of step (a) with a library of candidate nucleic acid molecules, wherein each nucleic acid molecule comprises a concatemer of a sequence comprising a candidate nuclease target site and a constant insert sequence of at least 10 and not more than 95 nucleotides, under conditions suitable for the nuclease to cut a candidate nucleic acid molecule comprising a target site of the nuclease; and (c) ligating a nucleic acid adapter onto the cut end of the candidate nucleic acid molecule; and (d) directly sequencing from the nucleic acid adapter in a single read-through an uncut target site adjacent the cut end, thereby identifying the target site of the nuclease.
An autonomous cleaning device comprising: a main body having an opening; a brush unit rotatably disposed in the opening of the main body; and a blade assembly to guide introduction of dust swept up by the brush unit, wherein the blade assembly comprises: a blade to guide dust toward an inner side of the main body; a support member coupled to the blade so as to support the blade and having one side in which a coupling groove is formed; characterised in that the blade assembly comprises further an insertion member inserted into the coupling groove of the support member. a main body having an opening; a brush unit rotatably disposed in the opening of the main body; and a blade assembly to guide introduction of dust swept up by the brush unit, a blade to guide dust toward an inner side of the main body; a support member coupled to the blade so as to support the blade and having one side in which a coupling groove is formed; characterised in that the blade assembly comprises further an insertion member inserted into the coupling groove of the support member.
Fixing element for an implant system comprising at least two fixing elements that are fixable to bone parts or the like and at least one connecting element that is fixable to the at least two fixing elements, wherein the fixing element comprises a distal end fixing part comprising a fixing section and a seating part which is connected to the fixing part, wherein the seating part comprises a connecting element seating for accommodating the connecting element and a fixing element for fixing the connecting element in the connecting element seating, wherein the seating part is formed from a seating part material, wherein the seating part comprises at least one reinforcement element which is formed from a reinforcement element material that has a greater stiffness and/or strength than the seating part material, wherein the seating part comprises at least one reinforcement element seating into which the at least one reinforcement element is inserted, characterized in that the at least one reinforcement element seating is sealed off, particularly by caulking a flange, and/or in that the fixing element comprises at least one closure element for sealing off the at least one reinforcement element seating.
A method of forming a multilayer confectionery sheet, wherein at least one of the confectionery sheets is a gum sheet, the method comprising: mixing gum ingredients to output a gum structure; forming a first confectionery into a first confectionery sheet having an average thickness between about 0.3mm and 10mm using a first forming station having a first set of forming drums; forming a second confectionery into a second confectionery sheet having an average thickness between about 0.3mm and 10mm using a second forming station having a second set of forming drums; wherein the gum structure is fed in a form of a non-uniform mass to at least one of the first and second forming stations to form the gum sheet; and laminating the first confectionery sheet and the second confectionery sheet to form a multilayer confectionery sheet. mixing gum ingredients to output a gum structure; forming a first confectionery into a first confectionery sheet having an average thickness between about 0.3mm and 10mm using a first forming station having a first set of forming drums; forming a second confectionery into a second confectionery sheet having an average thickness between about 0.3mm and 10mm using a second forming station having a second set of forming drums; wherein the gum structure is fed in a form of a non-uniform mass to at least one of the first and second forming stations to form the gum sheet; and laminating the first confectionery sheet and the second confectionery sheet to form a multilayer confectionery sheet.
A method implemented by a computing device, the method comprising: allocating reserved space for recovery on storage devices during configuration of a virtual disk; distributing client data and redundancy data across the storage devices in accordance with an allocation scheme that facilitates parallel recovery, wherein the allocation scheme represents a combination of multiple individual schemes that are applied selectively to different allocation operations, the multiple individual schemes including at least a bitmap scheme in which: each physical storage device maintains a bitmap indicative of its relations to other physical storage devices; and data is allocated to the physical storage devices using said bitmaps to prioritize and select combinations of the physical storage devices that have not been established for allocation of each particular portion of data to relocate; detecting failure of one or more of the storage devices; and recovering data from the one or more storage devices that fail using parallel tasks and the reserved space to redistribute the data across remaining storage devices that have not failed. allocating reserved space for recovery on storage devices during configuration of a virtual disk; distributing client data and redundancy data across the storage devices in accordance with an allocation scheme that facilitates parallel recovery, wherein the allocation scheme represents a combination of multiple individual schemes that are applied selectively to different allocation operations, the multiple individual schemes including at least a bitmap scheme in which: each physical storage device maintains a bitmap indicative of its relations to other physical storage devices; and data is allocated to the physical storage devices using said bitmaps to prioritize and select combinations of the physical storage devices that have not been established for allocation of each particular portion of data to relocate; each physical storage device maintains a bitmap indicative of its relations to other physical storage devices; and data is allocated to the physical storage devices using said bitmaps to prioritize and select combinations of the physical storage devices that have not been established for allocation of each particular portion of data to relocate; detecting failure of one or more of the storage devices; and recovering data from the one or more storage devices that fail using parallel tasks and the reserved space to redistribute the data across remaining storage devices that have not failed.
Panel for wall-, ceiling- or floor coverings, comprising an upper side, a lower side, and front ends, defining a circumference of the panel in the installed state, and at least one front end is protruded with respect to the circumference by a detachable protruding lip formed at the lower side, one horizontal locking groove being provided at the lower side, characterized in that, at least two detachable protruding lips are fixed at the panel at opposite sides of the panel, the protruding lips having a predetermined break-off surface, and the protruding lips comprising at least one horizontal locking element, being suitable for engaging in the horizontal locking groove of a neighbored panel, when the protruding lip of said neighbored panel has been removed. at least one front end is protruded with respect to the circumference by a detachable protruding lip formed at the lower side, one horizontal locking groove being provided at the lower side, characterized in that, at least two detachable protruding lips are fixed at the panel at opposite sides of the panel, the protruding lips having a predetermined break-off surface, and the protruding lips comprising at least one horizontal locking element, being suitable for engaging in the horizontal locking groove of a neighbored panel, when the protruding lip of said neighbored panel has been removed.
Distributor, in particular a spreading device with a storage container, a stirring apparatus which is preferably arranged in the lower region of the storage container and preferably has a stirring member and is preferably located above a metering means, wherein the stirring apparatus is set into a rotational movement, which runs only in one direction, by means of a free wheel actuated by a driven eccentric drive, wherein a connecting element is arranged between the free wheel and the stirring member of the stirring apparatus, wherein the connecting element (7, 18) arranged between the free wheel and the stirring member is torsionally elastic and/or designed as a torsion element, characterized in that the said connecting element (7, 18) permits an angle of torsion of the connecting element (7, 18) between the free wheel and the stirring member in relation to the stirring member, said angle of torsion being at least identical to, or greater than, the angle of torsion, which is produced by the eccentric, at the housing (15.1) of the free wheel, and in that the free wheel has, between the inner ring and outer ring (15.1), force-transmitting elements which transmit a force in the direction of rotation and do not act on the inner ring and outer ring (15.1) counter to the direction of rotation.
A trocar sleeve, comprising a hollow shaft which has a distal end and a proximal end and an approximately rectilinear shaft axis, an external thread rising from the outer face of the shaft, wherein at the shaft, seen from distal to proximal, a first external thread in the form of a helix is provided, the height of which, by which it rises from the outer face of the shaft, increases, and wherein, seen from distal to proximal, the pitch of the helix decreases, wherein the shaft consists of a flexible material in the form of a plastic material, and wherein, seen from distal to proximal, an angle (α) of the proximal flank of the helix with respect to the shaft axis decreases and approaches 90°.
A composition comprising an amino acid source for therapeutic use in combination with electrical muscular stimulation for the treatment or prevention of sarcopenia, for reducing the loss of muscle morphology, for increasing the muscle morphology and/or for improving the muscle recovery after muscle atrophy in elderly humans wherein said composition is in combination with at least one antioxidant and at least one fatty acid.
A therapeutically effective amount of a phytocannabinoid consisting essentially of tetrahydrocannabivarin (THCV) for use in the curative treatment of intestinal inflammatory diseases.
A stacking apparatus, comprising: a drive mechanism; a movable band connected to said drive mechanism, wherein said movable band is configured to be moved by said drive mechanism along an orbital path; a twin roller having first and second portions, wherein said first and second portions are configured to engage against said movable band and to fold said movable band into at least two band portions; and at least two orbiting members (142, 144) connected to said drive mechanism and said movable band, wherein said at least two orbiting members (142, 144) are disposed within said movable band and orbit along said orbital path with said movable band, and wherein at a predefined position of said orbiting members (142, 144), said movable band at least partially causes said twin roller to rotate about its center. a drive mechanism; a movable band connected to said drive mechanism, wherein said movable band is configured to be moved by said drive mechanism along an orbital path; a twin roller having first and second portions, wherein said first and second portions are configured to engage against said movable band and to fold said movable band into at least two band portions; and at least two orbiting members (142, 144) connected to said drive mechanism and said movable band, wherein said at least two orbiting members (142, 144) are disposed within said movable band and orbit along said orbital path with said movable band, and wherein at a predefined position of said orbiting members (142, 144), said movable band at least partially causes said twin roller to rotate about its center.
A method of storing potatoes, the method comprising the steps of: i. providing a plurality of dormant potatoes, wherein the potatoes have been cured after harvesting; ii. treating the potatoes with 1-methylcyclopropene, the treatment comprising exposing the potatoes, which are at a first treatment temperature within the range of from 10 to 30°C, to 1-methylcyclopropene; iii. storing the potatoes at a second storage temperature within the range of from greater than 1 to up to 6°C for a storage period within a potato store, wherein the storage period extends continuously until at least 1 week after initiation of eye movement in at least one of the potatoes, and wherein during the storage period the potatoes are stored in atmospheric air free of an external supply of ethylene sprout suppressant. i. providing a plurality of dormant potatoes, wherein the potatoes have been cured after harvesting; ii. treating the potatoes with 1-methylcyclopropene, the treatment comprising exposing the potatoes, which are at a first treatment temperature within the range of from 10 to 30°C, to 1-methylcyclopropene; iii. storing the potatoes at a second storage temperature within the range of from greater than 1 to up to 6°C for a storage period within a potato store, wherein the storage period extends continuously until at least 1 week after initiation of eye movement in at least one of the potatoes, and wherein during the storage period the potatoes are stored in atmospheric air free of an external supply of ethylene sprout suppressant.
A light source device comprising: a semiconductor laser configured to emit a laser beam, said semiconductor laser including a stem provided with a cut-away portion; and a holder member including a cylindrical portion configured to hold said semiconductor laser by said stem, wherein an inner surface of said cylindrical portion has an opposing surface opposing said stem in terms of the direction parallel to an optical axis of the laser beam as the stem is inserted into said cylindrical portion, characterized in that said opposing surface includes a contact portion disposed at a position corresponding to said cut-away portion and contacting said stem as the stem is inserted into said cylindrical portion, and said opposing surface includes a spaced portion which is spaced from said stem and remains separated from the stem as the stem is inserted into said cylindrical portion, so that production of air flow by way of said semiconductor laser, between an inner space of said cylindrical portion and an outside of said light source device is unlikely to occur. a semiconductor laser configured to emit a laser beam, said semiconductor laser including a stem provided with a cut-away portion; and a holder member including a cylindrical portion configured to hold said semiconductor laser by said stem, wherein an inner surface of said cylindrical portion has an opposing surface opposing said stem in terms of the direction parallel to an optical axis of the laser beam as the stem is inserted into said cylindrical portion, characterized in that said opposing surface includes a contact portion disposed at a position corresponding to said cut-away portion and contacting said stem as the stem is inserted into said cylindrical portion, and said opposing surface includes a spaced portion which is spaced from said stem and remains separated from the stem as the stem is inserted into said cylindrical portion, so that production of air flow by way of said semiconductor laser, between an inner space of said cylindrical portion and an outside of said light source device is unlikely to occur.
A method for loading a steam turbine, comprising: receiving a turbine loading factor; receiving a current steam turbine exhaust temperature; determining, by a controller, a steam flow ramping rate parameter and a steam temperature ramping rate parameter based at least in part on the turbine loading factor and the current steam turbine exhaust temperature, wherein the steam flow ramping rate parameter and the steam temperature ramping rate parameter are determined based at least in part on an inverse relationship between the steam flow ramping rate parameter and the steam temperature ramping rate parameter and wherein determining the steam flow ramping rate parameter and the steam temperature ramping rate parameter further comprises defining a function that generates a ramp rate split factor that increases along a positive slope as the current steam turbine exhaust temperature increases between two predefined temperatures, wherein the steam flow ramping rate parameter and the steam temperature ramping rate parameter are determined based on the ramp rate split factor; and controlling at least one of: (a) steam flow to the steam turbine based at least in part on the steam flow ramping rate parameter; or (b) steam temperature to the steam turbine based at least in part on the steam temperature ramping rate parameter. receiving a turbine loading factor; receiving a current steam turbine exhaust temperature; determining, by a controller, a steam flow ramping rate parameter and a steam temperature ramping rate parameter based at least in part on the turbine loading factor and the current steam turbine exhaust temperature, wherein the steam flow ramping rate parameter and the steam temperature ramping rate parameter are determined based at least in part on an inverse relationship between the steam flow ramping rate parameter and the steam temperature ramping rate parameter and wherein determining the steam flow ramping rate parameter and the steam temperature ramping rate parameter further comprises defining a function that generates a ramp rate split factor that increases along a positive slope as the current steam turbine exhaust temperature increases between two predefined temperatures, wherein the steam flow ramping rate parameter and the steam temperature ramping rate parameter are determined based on the ramp rate split factor; and controlling at least one of: (a) steam flow to the steam turbine based at least in part on the steam flow ramping rate parameter; or (b) steam temperature to the steam turbine based at least in part on the steam temperature ramping rate parameter.
A chewing gum base comprising a solution polymerized styrene-butadiene rubber having (i) a glass transition temperature Tg ranging from -20 °C to 0 °C and/or (ii) an intersection of G' with G" at a frequency between 100 and 10 5 rad/sec at 30 °C and 1% strain as measured following ASTM D4440-08; wherein the gum base comprises from 5 to 95 weight percent of the solution polymerized styrene-butadiene rubber.
A liquid laundry detergent composition comprising: (a) from 0.00001 to 0.05 wt% of a shading dye, wherein the shading dye chromophore is selected from the group comprising: mono-azo, bis-azo, triphenodioxazine, phthalocyanin, naptholactam, azine and anthraquinone; (b) from 1 to 70 wt% of a surfactant: (c) from 0.1 to 30 wt% of a modified lignin polymer; and, (d) the remainder of the composition being diluents and adjuncts to 100 wt %. (a) from 0.00001 to 0.05 wt% of a shading dye, wherein the shading dye chromophore is selected from the group comprising: mono-azo, bis-azo, triphenodioxazine, phthalocyanin, naptholactam, azine and anthraquinone; (b) from 1 to 70 wt% of a surfactant: (c) from 0.1 to 30 wt% of a modified lignin polymer; and, (d) the remainder of the composition being diluents and adjuncts to 100 wt %.
Automated guided vehicle comprising a frame which is designed to receive an auxiliary conveying means, and at least one displacement element which is designed to be extended and retracted in at least one horizontal direction relative to the frame, beyond the outer dimensions thereof, at least on one side, the displacement element further being designed to carry the auxiliary conveying means along therewith, characterized in that the displacement element has at least one gripper element which is designed to grip the auxiliary conveying means, the displacement element having at least one drive element which is designed to move the gripper element in the horizontal direction relative to the displacement element at least on one side. a frame which is designed to receive an auxiliary conveying means, and at least one displacement element which is designed to be extended and retracted in at least one horizontal direction relative to the frame, beyond the outer dimensions thereof, at least on one side, the displacement element further being designed to carry the auxiliary conveying means along therewith, characterized in that the displacement element has at least one gripper element which is designed to grip the auxiliary conveying means, the displacement element having at least one drive element which is designed to move the gripper element in the horizontal direction relative to the displacement element at least on one side.