A manufacturing method of an integrated fully-sealed liquid crystal screen comprising the following steps: 1) attaching a layer of solid UV flexible adhesives having a thickness of 50-300μm between every two adjacent components comprising a touch screen module or a screen protective glass, a supporting frame and a glass rear cover panel arranged in sequence, and then adhering the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence to form a sandwiched structure where the supporting frame is sandwiched by the glass rear cover panel and the touch screen module or the screen protective glass, and also embedding a liquid crystal screen module and an edge-lighting backlight module in the supporting frame, wherein the edge-lighting backlight module has a bottom reflector sheet and a light guiding panel, and the bottom reflector sheet is adhered to or printed on a back side of the light guiding panel, wherein the liquid crystal screen module is adhered to the touch screen module or the screen protective glass, and the edge-lighting backlight module adheres to the glass rear cover panel and is positioned in the supporting frame adjacent to a surface of the liquid crystal screen module opposite to a surface of the liquid crystal screen module which adheres to the touch screen module or the screen protective glass; 2) before adhering the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence of step 1, placing the components attached with the solid UV flexible adhesives into an autoclave for 10-250mins to eliminate bubbles, with pressure and temperature inside the autoclave maintained at 0.05MPa-1MPa and 30-65°C respectively; and then illuminating the components attached by the solid UV flexible adhesives using a high power UV light to solidify the solid UV flexible adhesives so as to adhere the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence as described in step 1 to form an integrated structure wherein all the gaps potentially existing between the touch screen module or the screen protective glass, the liquid crystal screen module and the edge-lighting backlight module are eliminated; 3) abrading and polishing edges of the integrated structure; coating the edges of the integrated structure with transparent sealer coating; and then drying the integrated structure. 1) attaching a layer of solid UV flexible adhesives having a thickness of 50-300μm between every two adjacent components comprising a touch screen module or a screen protective glass, a supporting frame and a glass rear cover panel arranged in sequence, and then adhering the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence to form a sandwiched structure where the supporting frame is sandwiched by the glass rear cover panel and the touch screen module or the screen protective glass, and also embedding a liquid crystal screen module and an edge-lighting backlight module in the supporting frame, wherein the edge-lighting backlight module has a bottom reflector sheet and a light guiding panel, and the bottom reflector sheet is adhered to or printed on a back side of the light guiding panel, wherein the liquid crystal screen module is adhered to the touch screen module or the screen protective glass, and the edge-lighting backlight module adheres to the glass rear cover panel and is positioned in the supporting frame adjacent to a surface of the liquid crystal screen module opposite to a surface of the liquid crystal screen module which adheres to the touch screen module or the screen protective glass; 2) before adhering the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence of step 1, placing the components attached with the solid UV flexible adhesives into an autoclave for 10-250mins to eliminate bubbles, with pressure and temperature inside the autoclave maintained at 0.05MPa-1MPa and 30-65°C respectively; and then illuminating the components attached by the solid UV flexible adhesives using a high power UV light to solidify the solid UV flexible adhesives so as to adhere the touch screen module or the screen protective glass, the supporting frame and the glass rear cover panel in sequence as described in step 1 to form an integrated structure wherein all the gaps potentially existing between the touch screen module or the screen protective glass, the liquid crystal screen module and the edge-lighting backlight module are eliminated; 3) abrading and polishing edges of the integrated structure; coating the edges of the integrated structure with transparent sealer coating; and then drying the integrated structure.