A flow control valve with safety coupling, comprising a hollow valve body provided with at least one first open tubular portion for fluid intake and at least one second open tubular portion for fluid discharge, a flow control element which is accommodated in said hollow valve body and is movable between at least one flow intake position and a flow control position, a stem for the movement of said flow control element which can be actuated by means of an actuation element, said second open tubular portion being configured to be able to rotate about its own axis of extension in order to produce engagement or disengagement with a safety coupling associated with a delivery duct of said fluid, wherein said second open tubular portion and said flow control element have respective mutual coupling portions which are shaped complementarily and are designed, when said flow control element is in the intake position, to determine the locking of said second open tubular portion around said axis of extension, with said flow control element in the flow control position said mutual coupling portions being mutually uncoupled so as to allow the rotation of said open tubular portion about said axis of extension, wherein said flow control element comprises a flow control ball which can rotate about an actuation axis, and wherein said axis of extension of said second open tubular portion is arranged substantially at right angles to said actuation axis; wherein said mutual coupling portions comprise a seat, which is formed on said second open tubular portion, and an engagement body, which can be accommodated in said seat formed on said flow control element, said seat comprising a saddle-shaped portion which is formed at the edge of said second open tubular portion that is directed toward said flow control element; characterized in that said engagement body comprises an engagement portion which is integral with said flow control element and is extended in a radial direction with respect to said actuation axis more than a recess which is arranged adjacent to said engagement body and is designed to face in a substantially parallel arrangement said edge of said second open tubular portion with said flow control element in the flow control condition. wherein said flow control element comprises a flow control ball which can rotate about an actuation axis, and wherein said axis of extension of said second open tubular portion is arranged substantially at right angles to said actuation axis; wherein said mutual coupling portions comprise a seat, which is formed on said second open tubular portion, and an engagement body, which can be accommodated in said seat formed on said flow control element, said seat comprising a saddle-shaped portion which is formed at the edge of said second open tubular portion that is directed toward said flow control element; characterized in that said engagement body comprises an engagement portion which is integral with said flow control element and is extended in a radial direction with respect to said actuation axis more than a recess which is arranged adjacent to said engagement body and is designed to face in a substantially parallel arrangement said edge of said second open tubular portion with said flow control element in the flow control condition.