An instrument comprising: an array of sample wells; a plurality of samples arranged in the array of sample wells, each sample comprising a plurality of components and a plurality of detectable markers, each of the plurality of detectable markers being capable of generating increased fluorescence emission due to a presence of a target component in the sample, each of the plurality of detectable markers having a respective excitation wavelength range and a respective emission wavelength range; a plurality of light sources each of the plurality of light sources capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite each of the detectable markers, each of the plurality of excitation wavelength ranges corresponding to a respective excitation wavelength range of a respective one of the plurality of detectable markers; a plurality of detectors, each of the plurality of detectors capable of detecting an emission wavelength range emitted from each of the plurality of detectable markers; a plurality of lenses, each of the plurality of lenses arranged to focus light emitted by a respective light source of the plurality of light sources into a respective sample and for focussing light emitted by the respective sample into a respective detector of the plurality of detectors, and a plurality of lightpipes, wherein each one of the plurality of lightpipes has a respective one of the plurality of light sources and a respective one of the plurality of detectors arranged at one end of the lightpipe and a respective one of the plurality of lenses arranged at the opposite end of the lightpipe. an array of sample wells; a plurality of samples arranged in the array of sample wells, each sample comprising a plurality of components and a plurality of detectable markers, each of the plurality of detectable markers being capable of generating increased fluorescence emission due to a presence of a target component in the sample, each of the plurality of detectable markers having a respective excitation wavelength range and a respective emission wavelength range; a plurality of light sources each of the plurality of light sources capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite each of the detectable markers, each of the plurality of excitation wavelength ranges corresponding to a respective excitation wavelength range of a respective one of the plurality of detectable markers; a plurality of detectors, each of the plurality of detectors capable of detecting an emission wavelength range emitted from each of the plurality of detectable markers; a plurality of lenses, each of the plurality of lenses arranged to focus light emitted by a respective light source of the plurality of light sources into a respective sample and for focussing light emitted by the respective sample into a respective detector of the plurality of detectors, and a plurality of lightpipes, wherein each one of the plurality of lightpipes has a respective one of the plurality of light sources and a respective one of the plurality of detectors arranged at one end of the lightpipe and a respective one of the plurality of lenses arranged at the opposite end of the lightpipe.