A compound represented by general formula: (wherein ring 1 represents a 5- or 6-membered monocyclic aromatic ring; R 1 represents -(CH 2) p -COOH, -(CH 2) q -COOR 11, -(CH 2) r -OH, -(CH 2) s -OR 12, -CH 2 NR 13 R 14 or -CONR 13 R 14; p represents an integer of 0 or 1 to 4; q represents an integer of 0 or 1 to 4; r represents an integer of 1 to 4; s represents an integer of 1 to 4; R 11 represents a C 1-4 alkyl group; R 12 represents a C 1-4 alkyl group or a C 1-4 acyl group; R 13 represents a hydrogen atom or a C 1-4 alkyl group; R 14 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 acyl group or a R 15 O(C=O)-C 1-4 alkyl group; or R 13 and R 14 together with a nitrogen atom to which R 13 and R 14 are bonded represents a saturated 5 to 8-membered cyclic amine; R 15 represents a hydrogen atom or a C 1-4 alkyl group; X represents-O-, -S-, -SO-, -SO 2 -, or -NH-; R 2 represents a hydrogen atom or a C 1-4 alkyl group; R 3 represents a hydrogen atom or -OR 31; R 31 represents a hydrogen atom, a C 1-4 alkyl group or a C 1-4 acyl group; E represents -O-, -S-, -SO-, -SO 2 -, -CH 2 -, =CH- or -NH-; ring 2 represents a 3 to 15-membered cyclic group; R 4 represents a C 1-8 alkyl group, a C 2-8 alkenyl group, a C 2-8 alkynyl group, a C 3-8 cycloalkyl group, a C 1-8 alkoxy group, a C 3-8 cycloalkyloxy group, a C 1-8 acyl group, a C 1-8 acyloxy group, a C 1-8 alkylthio group, a C 3-8 cycloalkylthio group, a C 1-8 alkylsulfinyl group, a C 3-8 cycloalkylsulfinyl group, a C 1-8 alkylsulfonyl group, a C 3-8 cycloalkylsulfonyl group, a C 1-8 alkoxycarbonyl group, a 5- or 6-membered cyclic group, a (5- or 6-membered cyclic group)-C 1-4 alkyl group, a (5- or 6-membered cyclic group)-C 1-4 alkoxy group, a (5- or 6-membered cyclic group)-C 1-4 acyl group, a halogen atom, a hydroxy group, a nitro group, a cyano group, -NR 16 R 17 -CONR 18 R 19 or -SO 2 NR 20 R 21; R 16, R 17, R 18, R 19, R 20 and R 21 each independently represent a hydrogen atom, a C 1-8 alkyl group, a C 1-8 acyl group or a C 1-8 alkylsulfonyl group; n represents an integer of 0 or 1 to 5, wherein multiple R 4 's may be the same as or different from each other when n is 2 or more, and each of groups to among the groups for R 4 may be substituted with one to three R 5 's; R 5 represents a C 1-4 alkyl group, a C 1-4 alkoxy group, a C 1-4 acyl group, a C 3-8 cycloalkyl group, -OH, -NR 22 R 23 or a halogen atom, wherein multiple R 5 's may be the same as or different from each other when each of groups to is substituted with the multiple R5's; R 22 and R 23 each independently represent a hydrogen atom or a C 1-4 alkyl group; ----- represents a single bond or a double bond; and represents an α-configuration, a β-configuration or a mixture thereof in an arbitrary ratio), a salt or N-oxide of the compound, or a solvate of the compound or the salt or N-oxide. (wherein ring 1 represents a 5- or 6-membered monocyclic aromatic ring; R 1 represents -(CH 2) p -COOH, -(CH 2) q -COOR 11, -(CH 2) r -OH, -(CH 2) s -OR 12, -CH 2 NR 13 R 14 or -CONR 13 R 14; p represents an integer of 0 or 1 to 4; q represents an integer of 0 or 1 to 4; r represents an integer of 1 to 4; s represents an integer of 1 to 4; R 11 represents a C 1-4 alkyl group; R 12 represents a C 1-4 alkyl group or a C 1-4 acyl group; R 13 represents a hydrogen atom or a C 1-4 alkyl group; R 14 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 acyl group or a R 15 O(C=O)-C 1-4 alkyl group; or R 13 and R 14 together with a nitrogen atom to which R 13 and R 14 are bonded represents a saturated 5 to 8-membered cyclic amine; R 15 represents a hydrogen atom or a C 1-4 alkyl group; X represents-O-, -S-, -SO-, -SO 2 -, or -NH-; R 2 represents a hydrogen atom or a C 1-4 alkyl group; R 3 represents a hydrogen atom or -OR 31; R 31 represents a hydrogen atom, a C 1-4 alkyl group or a C 1-4 acyl group; E represents -O-, -S-, -SO-, -SO 2 -, -CH 2 -, =CH- or -NH-; ring 2 represents a 3 to 15-membered cyclic group; R 4 represents a C 1-8 alkyl group, a C 2-8 alkenyl group, a C 2-8 alkynyl group, a C 3-8 cycloalkyl group, a C 1-8 alkoxy group, a C 3-8 cycloalkyloxy group, a C 1-8 acyl group, a C 1-8 acyloxy group, a C 1-8 alkylthio group, a C 3-8 cycloalkylthio group, a C 1-8 alkylsulfinyl group, a C 3-8 cycloalkylsulfinyl group, a C 1-8 alkylsulfonyl group, a C 3-8 cycloalkylsulfonyl group, a C 1-8 alkoxycarbonyl group, a 5- or 6-membered cyclic group, a (5- or 6-membered cyclic group)-C 1-4 alkyl group, a (5- or 6-membered cyclic group)-C 1-4 alkoxy group, a (5- or 6-membered cyclic group)-C 1-4 acyl group, a halogen atom, a hydroxy group, a nitro group, a cyano group, -NR 16 R 17 -CONR 18 R 19 or -SO 2 NR 20 R 21; R 16, R 17, R 18, R 19, R 20 and R 21 each independently represent a hydrogen atom, a C 1-8 alkyl group, a C 1-8 acyl group or a C 1-8 alkylsulfonyl group; n represents an integer of 0 or 1 to 5, wherein multiple R 4 's may be the same as or different from each other when n is 2 or more, and each of groups to among the groups for R 4 may be substituted with one to three R 5 's; R 5 represents a C 1-4 alkyl group, a C 1-4 alkoxy group, a C 1-4 acyl group, a C 3-8 cycloalkyl group, -OH, -NR 22 R 23 or a halogen atom, wherein multiple R 5 's may be the same as or different from each other when each of groups to is substituted with the multiple R5's; R 22 and R 23 each independently represent a hydrogen atom or a C 1-4 alkyl group; ----- represents a single bond or a double bond; and represents an α-configuration, a β-configuration or a mixture thereof in an arbitrary ratio), a salt or N-oxide of the compound, or a solvate of the compound or the salt or N-oxide.