A transdermal permeant delivery system for delivery of at least one permeant into a tissue membrane of a subject, comprising: a disposable substrate having an upper substrate surface and defining a poration area, the disposable substrate comprising a filament array having a plurality of filaments that are disposed in the poration area, wherein each filament is configured for forming a micropore in the tissue membrane; a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and a patch that is selectively removable from the top surface of the first release liner, comprising: a backing layer having an upper surface and an opposed lower surface; and a reservoir mounted on a portion of the lower surface of the backing layer and configured for releaseably containing the at least one permeant; wherein, in a connected position, a first portion of the backing layer is releaseably mounted to the top surface of the first release liner in spaced registration with the poration area of the substrate; wherein, in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate; wherein the filament array is mounted to a portion of the upper substrate surface, wherein the substrate further comprises a backing that is configured for mounting to and overlying a top surface of the filament array such that a portion of the filament array in the poration area is exposed; and wherein the filament array is a bi-clad foil material. a disposable substrate having an upper substrate surface and defining a poration area, the disposable substrate comprising a filament array having a plurality of filaments that are disposed in the poration area, wherein each filament is configured for forming a micropore in the tissue membrane; a first release liner having a top surface and an opposed bottom surface, wherein at least a portion of the bottom surface of the first release liner is connected to the upper substrate surface; and a patch that is selectively removable from the top surface of the first release liner, comprising: a backing layer having an upper surface and an opposed lower surface; and a reservoir mounted on a portion of the lower surface of the backing layer and configured for releaseably containing the at least one permeant; wherein, in a connected position, a first portion of the backing layer is releaseably mounted to the top surface of the first release liner in spaced registration with the poration area of the substrate; wherein, in the connected position, a second portion of the backing layer is folded back into a folded position, in which the lower surface of the second portion of the backing layer faces outwardly away from the upper substrate surface of the substrate; wherein the filament array is mounted to a portion of the upper substrate surface, wherein the substrate further comprises a backing that is configured for mounting to and overlying a top surface of the filament array such that a portion of the filament array in the poration area is exposed; and wherein the filament array is a bi-clad foil material.