mhurhangee/ep-ind-claims huggingface dataset:
A bispecific antibody specifically binding to the two targets which are the extracellular domain of human B cell maturation antigen (further named also as "BCMA") and human CD3ε (further named also as "CD3"), characterized in comprising a) the first light chain and the first heavy chain of a first antibody which specifically binds to BCMA; and b) the second light chain and the second heavy chain of a second antibody which specifically binds to CD3, and wherein the variable domains VL and VH in the second light chain and second heavy chain of the second antibody are replaced by each other; and wherein c) in the constant domain CL of the first light chain under a) the amino acid at position 124 is substituted independently by lysine, arginine or histidine (numbering according to Kabat), and wherein in the constant domain CH1 of the first heavy chain under a) the amino acid at position 147 and the amino acid at position 213 is substituted independently by glutamic acid, or aspartic acid (numbering according to Kabat). a) the first light chain and the first heavy chain of a first antibody which specifically binds to BCMA; and b) the second light chain and the second heavy chain of a second antibody which specifically binds to CD3, and wherein the variable domains VL and VH in the second light chain and second heavy chain of the second antibody are replaced by each other; and wherein c) in the constant domain CL of the first light chain under a) the amino acid at position 124 is substituted independently by lysine, arginine or histidine (numbering according to Kabat), and wherein in the constant domain CH1 of the first heavy chain under a) the amino acid at position 147 and the amino acid at position 213 is substituted independently by glutamic acid, or aspartic acid (numbering according to Kabat).
An immunochromatographic device comprising an immunochromatographic test piece for extracting and measuring a sugar chain antigen in a specimen, and a container which stores the test piece, the immunochromatographic device having a specimen addition port in a sample pad of the test piece, the immunochromatographic test piece comprising: a sample pad to which a specimen mixed with nitrite or an acid solution is added; a label region comprising a labeled antibody obtained by labeling an antibody against the sugar chain antigen; and a detection region on which the antibody against the sugar chain antigen is immobilized, wherein an antibody-sugar chain antigen-labeled antibody complex is formed in the detection region to measure the sugar chain antigen, and the immunochromatographic test piece having a region impregnated with a neutralizing reagent upstream of the label region, and further having a region impregnated with a solid acid reagent when the specimen mixed with the nitrite is used, or a region impregnated with nitrite when the specimen mixed with the acid solution is used, upstream of the region impregnated with the neutralizing reagent, wherein the immunochromatographic device (i) has a specimen addition port with a size of 24 to 75 mm 2 for promoting the extraction of the sugar chain antigen with the nitrite and the solid acid reagent by retaining an added specimen sample solution and supplying the specimen sample solution in a short time to the region impregnated with the solid acid reagent or the nitrite, and (ii) has no space between the addition port and the sample pad so as to prevent the sample from escaping from the addition port. (i) has a specimen addition port with a size of 24 to 75 mm 2 for promoting the extraction of the sugar chain antigen with the nitrite and the solid acid reagent by retaining an added specimen sample solution and supplying the specimen sample solution in a short time to the region impregnated with the solid acid reagent or the nitrite, and (ii) has no space between the addition port and the sample pad so as to prevent the sample from escaping from the addition port.
A computer-implemented method of operating an image segmentation system, the method comprising: collecting at least one image of a scene, wherein the scene comprises a plurality of distinct objects; generating a plurality of segmentation predictions for the scene, wherein each segmentation prediction of the plurality of segmentation predictions includes a plurality of object regions each representing a region predicted to correspond to a single object and a confidence associated with the prediction of each region; and outputting a final segmentation prediction comprising at least one identified object region, wherein the at least one identified object region is chosen based on the confidence associated with the at least one identified object region and a confidence threshold, wherein the confidence associated with the at least one identified object region is greater than the confidence threshold, wherein outputting the final segmentation prediction comprises: identifying the confidence threshold, wherein the confidence threshold corresponds to a minimum percentage; and wherein the at least one identified object region is a region where the minimum percentage of segmentation predictions from the plurality of segmentation predictions overlap. collecting at least one image of a scene, wherein the scene comprises a plurality of distinct objects; generating a plurality of segmentation predictions for the scene, wherein each segmentation prediction of the plurality of segmentation predictions includes a plurality of object regions each representing a region predicted to correspond to a single object and a confidence associated with the prediction of each region; and outputting a final segmentation prediction comprising at least one identified object region, wherein the at least one identified object region is chosen based on the confidence associated with the at least one identified object region and a confidence threshold, wherein the confidence associated with the at least one identified object region is greater than the confidence threshold, wherein outputting the final segmentation prediction comprises: identifying the confidence threshold, wherein the confidence threshold corresponds to a minimum percentage; and wherein the at least one identified object region is a region where the minimum percentage of segmentation predictions from the plurality of segmentation predictions overlap. a minimum percentage; and wherein the at least one identified object region is a region where the minimum percentage of segmentation predictions from the plurality of segmentation predictions overlap.
A method for wireless communication, comprising: identifying, at an access point -AP-, one or more conditions for one or both of disabling or enabling uplink -UL- transmissions of a request-to-send/clear-to-send -RTS/CTS- protocol at a station -STA- associated with the AP, wherein identifying the one or more conditions comprises identifying a packet type for which to disable the UL transmissions of the RTS/CTS protocol at the STA; and transmitting a configuration message to the STA, the configuration message including configuration information indicating the one or more conditions that includes the packet type. identifying, at an access point -AP-, one or more conditions for one or both of disabling or enabling uplink -UL- transmissions of a request-to-send/clear-to-send -RTS/CTS- protocol at a station -STA- associated with the AP, wherein identifying the one or more conditions comprises identifying a packet type for which to disable the UL transmissions of the RTS/CTS protocol at the STA; and transmitting a configuration message to the STA, the configuration message including configuration information indicating the one or more conditions that includes the packet type.
A system for a quantitative detection of a movement, the system comprising: • a signal emitter and two signal receivers (202, 204), positioned in series, along a first axis parallel to a second axis of movement of a reflective marker, provided on a moving object, wherein the reflective marker is configured to reflect the signal emitted by the emitter towards the receivers (202, 204); • the two receivers (202, 204) have a signal reception coverage such that allows existence of a reflective marker position, on the second axis, in which the reflective marker of a given size is recognized simultaneously by the two receivers (202, 204) the system being characterized in that the size H m of the reflective marker in the second axis is calculated as a function of: • a distance D em between the first and the second axes; • a distance D er0 between the emitter and the first receiver; • a distance D er1 between the emitter and the second receiver; • a signal emitting angle β e of the emitter; • a signal reception angle a r0 of the first receiver; and • a signal reception angle a r1 of the second receiver; wherein H m ≥ D er 0 + D er 1 2 for D em ≥ D er 0 2 ⋅ tg min β e α r 0 2 and D em ≥ D er 1 2 ⋅ tg min β e α r 1 2 whereas when the D er0 is different from the D er1, the greater one of the two is applied to determine the D em. • a signal emitter and two signal receivers (202, 204), positioned in series, along a first axis parallel to a second axis of movement of a reflective marker, provided on a moving object, wherein the reflective marker is configured to reflect the signal emitted by the emitter towards the receivers (202, 204); • the two receivers (202, 204) have a signal reception coverage such that allows existence of a reflective marker position, on the second axis, in which the reflective marker of a given size is recognized simultaneously by the two receivers (202, 204) • a distance D em between the first and the second axes; • a distance D er0 between the emitter and the first receiver; • a distance D er1 between the emitter and the second receiver; • a signal emitting angle β e of the emitter; • a signal reception angle a r0 of the first receiver; and • a signal reception angle a r1 of the second receiver;
A signal processing system adapted to process a plurality of channel signals (x i) supplied from an array of sensors of different operating characteristics, comprising calibration circuitry adapted to produce a plurality of normalized channel signals, x i /( x i) 2, by normalizing each channel signal, x i, by the respective average, ( x i) 2, to determine a reference value, s 0, common to all channel signals on the basis of said respective average, ( x i) 2, and to produce calibrated channel signals, y i, that are equal to said normalized channel signals, x i /( x i) 2, scaled respectively by said reference value, so.
An ink composition for deflected continuous ink jet printing, liquid at room temperature, comprising: a) a solvent comprising, preferably consisting of, one or several organic solvent compound(s) and optionally water; preferably, the solvent represents at least 20% by weight of the total weight of the ink composition, preferably the solvent represents from 30% to 90% by weight, still preferably from 60% to 80% by weight, of the total weight of the ink composition; b) a binder, comprising at least one polyester resin prepared by polymerization of terephthalic acid, isophthalic acid, neopentylglycol, and ethyleneglycol; preferably, the ink composition comprises from 0.1% to 30% by weight, preferably from 5% to 20% by weight, of the total weight of the ink composition, of the polyester resin; c) optionally one or several dye(s) and/or pigment(s); preferably, the total amount of dye(s) and/or of pigment(s) is from 0.05% to 25% by weight, preferably from 1% to 20% by weight, still preferably from 3% to 10% by weight, of the total weight of the ink composition; said ink composition further comprising a resin derived from rosin; preferably, the ink composition comprises from 0.1% to 20% by weight, preferably from 1% to 15% by weight, of the total weight of the ink composition, of the resin derived from rosin. a) a solvent comprising, preferably consisting of, one or several organic solvent compound(s) and optionally water; preferably, the solvent represents at least 20% by weight of the total weight of the ink composition, preferably the solvent represents from 30% to 90% by weight, still preferably from 60% to 80% by weight, of the total weight of the ink composition; b) a binder, comprising at least one polyester resin prepared by polymerization of terephthalic acid, isophthalic acid, neopentylglycol, and ethyleneglycol; preferably, the ink composition comprises from 0.1% to 30% by weight, preferably from 5% to 20% by weight, of the total weight of the ink composition, of the polyester resin; c) optionally one or several dye(s) and/or pigment(s); preferably, the total amount of dye(s) and/or of pigment(s) is from 0.05% to 25% by weight, preferably from 1% to 20% by weight, still preferably from 3% to 10% by weight, of the total weight of the ink composition;
A liquid crystal cell, comprising: a first lower substrate, with a first overcoat layer being formed on a surface of the first substrate, the first substrate having a first region and a second region, and a barrier layer being formed on the surface of the first overcoat layer in the first region; a second upper substrate bonded with the first substrate, with a second overcoat layer being formed on a surface of the second substrate that is close to the first substrate, a first spacer being formed on the surface of the second overcoat layer in the first region and a second spacer being formed on the surface of the second overcoat layer in the second region, wherein the length of the first spacer is greater than the length of the second spacer, a black matrix layer and a color filter layer formed on the black matrix layer are formed between the second substrate and the second overcoat layer, and the hardness of the second overcoat layer is substantially the same as the hardness of the first overcoat layer; a liquid crystal layer formed between the first substrate and the second substrate, wherein the area of a lower surface of the barrier layer is greater than the area of a lower surface of the first spacer, the barrier layer is provided between the surface of the first overcoat layer and the first spacer at a position corresponding to the first spacer, and the hardness of the first overcoat layer is less than that of the second substrate. a first lower substrate, with a first overcoat layer being formed on a surface of the first substrate, the first substrate having a first region and a second region, and a barrier layer being formed on the surface of the first overcoat layer in the first region; a second upper substrate bonded with the first substrate, with a second overcoat layer being formed on a surface of the second substrate that is close to the first substrate, a first spacer being formed on the surface of the second overcoat layer in the first region and a second spacer being formed on the surface of the second overcoat layer in the second region, wherein the length of the first spacer is greater than the length of the second spacer, a black matrix layer and a color filter layer formed on the black matrix layer are formed between the second substrate and the second overcoat layer, and the hardness of the second overcoat layer is substantially the same as the hardness of the first overcoat layer; a liquid crystal layer formed between the first substrate and the second substrate, wherein the area of a lower surface of the barrier layer is greater than the area of a lower surface of the first spacer, the barrier layer is provided between the surface of the first overcoat layer and the first spacer at a position corresponding to the first spacer, and the hardness of the first overcoat layer is less than that of the second substrate.
Arrangement for assembling an armrest to the lining of a door, the arrangement comprising said lining and said armrest, characterized in that the armrest is a shell, and is assembled on means for retaining the lining of the door designed on an edge of openings, by clipping means directed along a lateral direction of the door which corresponds to the longitudinal direction of the armrest, clipping means being constituted in the form of hooking elements comprising a body extended by a bevel and are distributed over the inner periphery of the shell forming the armrest.
An optoelectronic component for receiving light, which component comprises a housing (3; 13; 23; 33; 53; 63; 73; 83; 93; 103) with an axially extending cavity (4; 14; 24; 34) arranged to receive an incoming beam; at least one adjustable arrangement comprising at least one lens (6; 16; 26; 36; 56; 66; 76; 86; 96; 106), and a first adjustment means (Ax, Ay; A1, A2) for adjusting the focal point of said lens relative to the end surface of an optical fiber (2; 12; 22; 32; 57; 67; 74, 77; 87a, 87b; 94; 107) connectable to the housing; characterized in that the arrangement further comprises a first body (7; 17; 27; 37) supporting the lens (6; 16; 26; 36; 56; 66; 76; 86; 96; 106) and to influence said lens position; a second body (8; 18; 28; 38) contacting the first body and comprising a spherical bearing allowing the first body (7; 17; 27; 37) to be journalled about a point (P; P1; P2; P3) in the housing distant from the lens; and that wherein the first adjustment means (A1, A2) is arranged to act on the first body (7; 17; 27; 37) remote from the second body (8; 18; 28; 38), and to adjust the axis of the first body in two orthogonal directions relative to the axis of the housing by means of the spherical bearing in the second body (8; 18; 28; 38) to rotate the first body spherically around the distant point (P; P1; P2; P3) to alter the position of said lens, in order to locate the focal point of the lens on the end surface of the optical fiber a second body (8; 18; 28; 38) contacting the first body and comprising a spherical bearing allowing the first body (7; 17; 27; 37) to be journalled about a point (P; P1; P2; P3) in the housing distant from the lens; and that wherein the first adjustment means (A1, A2) is arranged to act on the first body (7; 17; 27; 37) remote from the second body (8; 18; 28; 38), and to adjust the axis of the first body in two orthogonal directions relative to the axis of the housing by means of the spherical bearing in the second body (8; 18; 28; 38) to rotate the first body spherically around the distant point (P; P1; P2; P3) to alter the position of said lens, in order to locate the focal point of the lens on the end surface of the optical fiber
A compound and/or a pharmaceutically acceptable salt thereof, wherein the compound is chosen from: -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-11-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile; -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-11-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-(5,6-dihydroimidazo[1,2-a]pyrazin-7 -yl)-4-methylpent-2-enenitrile; and -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-(5,6-dihydroimidazo[1,2-a]pyrazin-7 -yl)-4-methylpent-2-enenitrile, or a mixture of R and S isomers thereof, or an or isomer of any one of the above compounds. -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-11-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile; -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-11-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; 2-( -3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-( -hexahydropyrazino[2,1-c][1,4]oxazin-8 -yl)-4-methylpent-2-enenitrile; -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-(5,6-dihydroimidazo[1,2-a]pyrazin-7 -yl)-4-methylpent-2-enenitrile; and -2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4-(5,6-dihydroimidazo[1,2-a]pyrazin-7 -yl)-4-methylpent-2-enenitrile,
A circular saw mounting device which rotatably supports a saw blade in a grinding machine, which the mounting device comprises a base plate adapted for mounting in a grinding machine; and a centering element comprising at least two engagement elements configured to be operated in a radial direction between a mounting position and a locking position; characterised in that the mounting device further comprises an actuator comprising a pin being configured to be operated in an axial direction and arranged to engage with pivot articulated couplings (63, 64, 65) to each of the engagement elements to thereby transfer a radial displacement to the at least two engagement elements and to thereby operate the at least two engagement elements between the mounting position and the locking position, wherein the mounting device on a first surface thereof has a mounting bracket which is arranged for mounting and locking the mounting device in a grinding machine, and wherein the centering element is rotatably arranged in relation to the base plate with bearings.
A pull-out tester for a setting tool for setting a powder-actuated fastener, said pull-out tester comprising: - a holding portion for holding the powder-actuated fastener, - an elastic element, - at least one means for transmitting a pull-out force acting on the fastener to the elastic element, characterized in that when a pull-out test force acting on the powder-actuated fastener is exceeded, the connection between fastener and pull-out tester can be broken owing to a deformation of the elastic element, wherein the force transmitted to the elastic element for deformation of the elastic element substantially produces an elastic deformation of said elastic element and, owing to the substantially elastic deformation of the elastic element, the connection between powder-actuated fastener and pull-out tester can be broken. - a holding portion for holding the powder-actuated fastener, - an elastic element, - at least one means for transmitting a pull-out force acting on the fastener to the elastic element,