A syringe comprising: a barrel comprising a gripping flange at a proximal end, an opening at a distal end for receiving a needle hub, a wall structure comprising an exterior surface and an interior surface defining an interior cavity, and a pair of female detents (46a, 48b) on the interior surface positioned closer to the distal end than the proximal end; a plunger disposed in the interior cavity of the barrel, the plunger comprising a push flange at a proximal end, and a tip holder comprising a plunger tip (34, 100) mounted thereon proximate a distal end; wherein said plunger tip (34, 100) comprises a plunger tip distal end surface spaced apart from the push flange by a first distance; and a carriage disposed in the interior cavity of the barrel, the carriage comprising a Luer tip, a passage, a pair of arms (40a, 40b) extending away from the Luer tip with each arm (40a, 40b) comprising a male detent (46a, 46b); wherein the carriage is removably secured to the barrel by engaging the male detents (46a, 46b) on the carriage with the female detents (48a, 48b) on the barrel; and wherein the plunger comprises three plunger positions including a first plunger position in which the plunger tip positioned on the plunger is spaced apart from the carriage; a second plunger position in which the plunger tip or the tip holder holding the plunger tip (34, 100) contacts the carriage, wherein the male detents (46a, 46b) on the carriage remain engaged with the female detents (48a, 48b) on the barrel; and a third plunger position in which the male detents (46a, 46b) on the carriage separate from the female detents (48a, 48b) on the barrel; characterized in that the tip holder comprises a plunger disc (60, 106) for pushing on an end of the plunger tip when the plunger moves distally and a shroud arranged distal of the plunger disc (60, 106) in a bore (68, 101) provided in the plunger tip (34, 100), the shroud comprising a pair of receiving slots for receiving the arms (40a, 40b) of the carriage, wherein in the third plunger position the arms (40a, 40b) of the carriage engage with the receiving slots of the shroud, and wherein by applying an actuated force on the plunger being in the second plunger position, the push flange on the plunger is moveable a distal direction relative to the plunger tip distal end surface for bringing the plunger into the third plunger position, in which third plunger position the push flange is spaced apart from the plunger tip distal end surface by a second distance, which is less than the first distance. a barrel comprising a gripping flange at a proximal end, an opening at a distal end for receiving a needle hub, a wall structure comprising an exterior surface and an interior surface defining an interior cavity, and a pair of female detents (46a, 48b) on the interior surface positioned closer to the distal end than the proximal end; a plunger disposed in the interior cavity of the barrel, the plunger comprising a push flange at a proximal end, and a tip holder comprising a plunger tip (34, 100) mounted thereon proximate a distal end; wherein said plunger tip (34, 100) comprises a plunger tip distal end surface spaced apart from the push flange by a first distance; and a carriage disposed in the interior cavity of the barrel, the carriage comprising a Luer tip, a passage, a pair of arms (40a, 40b) extending away from the Luer tip with each arm (40a, 40b) comprising a male detent (46a, 46b); wherein the carriage is removably secured to the barrel by engaging the male detents (46a, 46b) on the carriage with the female detents (48a, 48b) on the barrel; and wherein the plunger comprises three plunger positions including a first plunger position in which the plunger tip positioned on the plunger is spaced apart from the carriage; a second plunger position in which the plunger tip or the tip holder holding the plunger tip (34, 100) contacts the carriage, wherein the male detents (46a, 46b) on the carriage remain engaged with the female detents (48a, 48b) on the barrel; and a third plunger position in which the male detents (46a, 46b) on the carriage separate from the female detents (48a, 48b) on the barrel; characterized in that the tip holder comprises a plunger disc (60, 106) for pushing on an end of the plunger tip when the plunger moves distally and a shroud arranged distal of the plunger disc (60, 106) in a bore (68, 101) provided in the plunger tip (34, 100), the shroud comprising a pair of receiving slots for receiving the arms (40a, 40b) of the carriage, wherein in the third plunger position the arms (40a, 40b) of the carriage engage with the receiving slots of the shroud, and wherein by applying an actuated force on the plunger being in the second plunger position, the push flange on the plunger is moveable a distal direction relative to the plunger tip distal end surface for bringing the plunger into the third plunger position, in which third plunger position the push flange is spaced apart from the plunger tip distal end surface by a second distance, which is less than the first distance.