A system comprising a dual illumination system and an imaging apparatus, the imaging apparatus defining a light-tight imaging compartment with an interior wall having a view port extending into the imaging compartment to enable a camera of the imaging apparatus to acquire data of a specimen contained in the imaging compartment, the dual illumination system comprising: a first illumination assembly configured to direct structured light onto a side of the specimen facing the view port to enable structured light imaging and surface topography measurements of the specimen; and a second illumination assembly configured to direct excitation light at the specimen whereby diffused fluorescent light emanates from the surface of the specimen facing the view port for receipt through the view port by the camera, wherein the second illumination assembly comprises: a trans-illumination device configured to direct excitation light into a surface of the specimen facing away from the view port opposite the viewport whereby the diffused fluorescent light exits the surface facing the view port for receipt through the view port by the camera, wherein the trans-illumination device comprises: a lens assembly configured to focus the excitation light from the trans-illumination device onto the specimen; and a translation platform configured to position an output end of the trans-illumination device at one of a plurality of positions adjacent the surface of the specimen facing away from the view port; and an epi-illumination device configured to direct excitation light onto the surface of the specimen facing the viewport. a first illumination assembly configured to direct structured light onto a side of the specimen facing the view port to enable structured light imaging and surface topography measurements of the specimen; and a second illumination assembly configured to direct excitation light at the specimen whereby diffused fluorescent light emanates from the surface of the specimen facing the view port for receipt through the view port by the camera, wherein the second illumination assembly comprises: a trans-illumination device configured to direct excitation light into a surface of the specimen facing away from the view port opposite the viewport whereby the diffused fluorescent light exits the surface facing the view port for receipt through the view port by the camera, wherein the trans-illumination device comprises: a lens assembly configured to focus the excitation light from the trans-illumination device onto the specimen; and a translation platform configured to position an output end of the trans-illumination device at one of a plurality of positions adjacent the surface of the specimen facing away from the view port; and a trans-illumination device configured to direct excitation light into a surface of the specimen facing away from the view port opposite the viewport whereby the diffused fluorescent light exits the surface facing the view port for receipt through the view port by the camera, wherein the trans-illumination device comprises: a lens assembly configured to focus the excitation light from the trans-illumination device onto the specimen; and a translation platform configured to position an output end of the trans-illumination device at one of a plurality of positions adjacent the surface of the specimen facing away from the view port; and a lens assembly configured to focus the excitation light from the trans-illumination device onto the specimen; and a translation platform configured to position an output end of the trans-illumination device at one of a plurality of positions adjacent the surface of the specimen facing away from the view port; and an epi-illumination device configured to direct excitation light onto the surface of the specimen facing the viewport.