A endoscopic clipping system (100, 200, 300) for treating tissue, comprising: a clip assembly (102, 202, 302) including a pair of clip arms (114, 314), each of the clip arms extending from a proximal end to a distal end, proximal ends of the clip arms (114, 314) slidably received within a channel (140, 240) of a capsule (108, 208, 308, 508) to be moved between a tissue receiving configuration, in which distal ends of the clip arms (114, 314) are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms (114, 314) are moved toward one another; an applicator (104, 204, 304) including a catheter (110, 210, 310) and a control member extending therethrough, the control member including a distal end configured to be connected to the clip arms (114, 314) to move the clip assembly (102, 202, 302) between the tissue receiving configuration and the tissue clipping configuration; and a coupler (106, 206, 306, 406, 506) attached to a proximal end (136, 236) of the capsule (108, 208, 308, 508) of the clip assembly (102, 202, 302), the coupler (106, 206, 306, 406, 506) configured to releasably couple the capsule (102, 202, 302) and the catheter (110, 210, 310) to one another; wherein a proximal portion of the coupler (106, 206, 306, 406, 506) includes a plurality of deflectable arms (156, 276, 276', 376); characterized in that the plurality of deflectable arms (156, 276, 276', 376) is configured to be mounted over the distal end (160, 260, 360) of the catheter (110, 210, 310), wherein the arms (156, 276, 276', 376) are biased toward an engaging configuration and are configured to be spread apart to permit the distal end (160, 260, 360) of the catheter (110, 210, 310) to be received therebetween. a clip assembly (102, 202, 302) including a pair of clip arms (114, 314), each of the clip arms extending from a proximal end to a distal end, proximal ends of the clip arms (114, 314) slidably received within a channel (140, 240) of a capsule (108, 208, 308, 508) to be moved between a tissue receiving configuration, in which distal ends of the clip arms (114, 314) are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms (114, 314) are moved toward one another; an applicator (104, 204, 304) including a catheter (110, 210, 310) and a control member extending therethrough, the control member including a distal end configured to be connected to the clip arms (114, 314) to move the clip assembly (102, 202, 302) between the tissue receiving configuration and the tissue clipping configuration; and a coupler (106, 206, 306, 406, 506) attached to a proximal end (136, 236) of the capsule (108, 208, 308, 508) of the clip assembly (102, 202, 302), the coupler (106, 206, 306, 406, 506) configured to releasably couple the capsule (102, 202, 302) and the catheter (110, 210, 310) to one another; wherein a proximal portion of the coupler (106, 206, 306, 406, 506) includes a plurality of deflectable arms (156, 276, 276', 376); characterized in that the plurality of deflectable arms (156, 276, 276', 376) is configured to be mounted over the distal end (160, 260, 360) of the catheter (110, 210, 310), wherein the arms (156, 276, 276', 376) are biased toward an engaging configuration and are configured to be spread apart to permit the distal end (160, 260, 360) of the catheter (110, 210, 310) to be received therebetween.