A switching control module comprising: a measurement receiver configured for measuring a signal power in a downlink path of a distributed antenna system; and a processor communicatively coupled to the measurement receiver, wherein the processor is configured for optimizing time division duplexing operations of the distributed antenna system by: determining an initial clock setting that controls a timing for generating switching signals that instruct at least one switch (212, 214, 216) in an uplink path or the downlink path of the distributed antenna system to switch the distributed antenna system between an uplink mode and a downlink mode, wherein the processor is configured for determining the initial clock setting by performing operations comprising: obtaining multiple downlink sub-frame samples, wherein each downlink frame sample corresponds to a respective power measurement by the measurement receiver; determining a ratio between downlink sub-frames and uplink sub-frames for signals communicated via the distributed antenna system; and determining the initial clock setting based on the ratio; determining multiple start times or end times for respective downlink sub-frames transmitted via the downlink path, wherein the processor is configured for determining each start time or end time based on the signal power measured by the measurement receiver exceeding a threshold signal power, and updating the initial clock setting based on a switching time adjustment statistically determined from multiple switching time differentials, wherein each of the switching time differentials comprises a respective difference between the initial clock setting and a respective start time or end time. a measurement receiver configured for measuring a signal power in a downlink path of a distributed antenna system; and a processor communicatively coupled to the measurement receiver, wherein the processor is configured for optimizing time division duplexing operations of the distributed antenna system by: determining an initial clock setting that controls a timing for generating switching signals that instruct at least one switch (212, 214, 216) in an uplink path or the downlink path of the distributed antenna system to switch the distributed antenna system between an uplink mode and a downlink mode, wherein the processor is configured for determining the initial clock setting by performing operations comprising: obtaining multiple downlink sub-frame samples, wherein each downlink frame sample corresponds to a respective power measurement by the measurement receiver; determining a ratio between downlink sub-frames and uplink sub-frames for signals communicated via the distributed antenna system; and determining the initial clock setting based on the ratio; determining multiple start times or end times for respective downlink sub-frames transmitted via the downlink path, wherein the processor is configured for determining each start time or end time based on the signal power measured by the measurement receiver exceeding a threshold signal power, and updating the initial clock setting based on a switching time adjustment statistically determined from multiple switching time differentials, wherein each of the switching time differentials comprises a respective difference between the initial clock setting and a respective start time or end time. determining an initial clock setting that controls a timing for generating switching signals that instruct at least one switch (212, 214, 216) in an uplink path or the downlink path of the distributed antenna system to switch the distributed antenna system between an uplink mode and a downlink mode, wherein the processor is configured for determining the initial clock setting by performing operations comprising: obtaining multiple downlink sub-frame samples, wherein each downlink frame sample corresponds to a respective power measurement by the measurement receiver; determining a ratio between downlink sub-frames and uplink sub-frames for signals communicated via the distributed antenna system; and determining the initial clock setting based on the ratio; obtaining multiple downlink sub-frame samples, wherein each downlink frame sample corresponds to a respective power measurement by the measurement receiver; determining a ratio between downlink sub-frames and uplink sub-frames for signals communicated via the distributed antenna system; and determining the initial clock setting based on the ratio; determining multiple start times or end times for respective downlink sub-frames transmitted via the downlink path, wherein the processor is configured for determining each start time or end time based on the signal power measured by the measurement receiver exceeding a threshold signal power, and updating the initial clock setting based on a switching time adjustment statistically determined from multiple switching time differentials, wherein each of the switching time differentials comprises a respective difference between the initial clock setting and a respective start time or end time.