mhurhangee/ep-ind-claims huggingface dataset:
A method for selecting an immunoglobulin able to bind in an intracellular environment to a post-translationally modified target or for determining the ability of an immunoglobulin to bind in an intracellular environment to a post-translationally modified target, said method comprising the steps of: a) providing a nucleic acid encoding for an intracellular immunoglobulin which is associated with a first molecule; and b) providing a nucleic acid encoding for an intracellular target which is: - fuse to an enzyme that modifies in vivo the target or - subjected to a direct site-specific genetic encoding of the Post-Translational Modifications into the target protein and - a second molecule, wherein said first and second molecules are separable domains of a reporter molecule; and c) expressing said first nucleotide sequence together with said second nucleotide sequence in an intracellular environment, wherein binding of said immunoglobulin with said target leads to stable interaction of the first molecule and second molecule, thus producing a detectable reporter molecule that generates a signal, and d) detecting said signal from said detectable reporter molecule, wherein said detection of a signal is indicative of stable binding activity between said immunoglobulin and said target in the intracellular environment; e) isolating those immunoglobulins that stably bind to the target and optionally f) selecting those immunoglobulins that do not bind to target that is not post-translationally modified. a) providing a nucleic acid encoding for an intracellular immunoglobulin which is associated with a first molecule; and b) providing a nucleic acid encoding for an intracellular target which is: - fuse to an enzyme that modifies in vivo the target or - subjected to a direct site-specific genetic encoding of the Post-Translational Modifications into the target protein and - a second molecule, wherein said first and second molecules are separable domains of a reporter molecule; and - fuse to an enzyme that modifies in vivo the target or - subjected to a direct site-specific genetic encoding of the Post-Translational Modifications into the target protein and - a second molecule, c) expressing said first nucleotide sequence together with said second nucleotide sequence in an intracellular environment, wherein binding of said immunoglobulin with said target leads to stable interaction of the first molecule and second molecule, thus producing a detectable reporter molecule that generates a signal, and d) detecting said signal from said detectable reporter molecule, wherein said detection of a signal is indicative of stable binding activity between said immunoglobulin and said target in the intracellular environment; e) isolating those immunoglobulins that stably bind to the target and optionally f) selecting those immunoglobulins that do not bind to target that is not post-translationally modified.
A molded product, comprising a fiber-reinforced composite material containing reinforcing fibers having an average fiber length of 10 mm to 100 mm and a thermoplastic resin, wherein the molded product has thickness gradient, wherein an amount of the thermoplastic resin is 50 to 1,000 parts by weight per 100 parts by weight of the reinforcing fibers, wherein the reinforcing fibers contain a reinforcing fiber bundle comprising the reinforcing fibers of a critical single fiber number defined by formula or more, a ratio of the reinforcing fiber bundle to a total amount of the reinforcing fibers is 30 vol% or more and less than 90 vol%: Critical single fiber number = 600 / D wherein D is an average fiber diameter (μm) of single reinforcing fibers, wherein the reinforcing fibers have a fiber areal weight of from 25 g/m 2 to 3,000 g/m 2 and are substantially two-dimensionally randomly oriented, wherein the reinforcing fibers are carbon fibers, wherein an average number of fibers in the reinforcing fiber bundle satisfies formula: 0.7 × 10 4 / D 2 < N < 6 × 10 4 / D 2 wherein D is an average fiber diameter (μm) of the reinforcing fibers, and wherein a ratio obtained by dividing larger value by smaller value, of reinforcing fiber volume fraction (Vf) in each region having different thickness, is 1.0 to 1.2.
Electronic device with a housing designed to accommodate electronic components, preferably a process transmitter, wherein the housing has two chambers (2, 3) in which electronic components (4, 5, 6, 7, 8) and user interfaces (12, 14, 15, 16) and/or connection elements (10, 11) for cables are arranged, wherein the electronic components (4, 5, 6, 7) are arranged in a first chamber, and the first chamber exclusively contains electronic components (4, 5, 6, 7, 8), whereas user interfaces (12, 14, 15, 16) of the electronic components (4, 5, 6, 7, 8) and/or connection elements (10, 11) for cables are arranged exclusively in the second chamber, characterized in that the user interfaces (12, 14, 15, 16) and/or the connection elements (10, 11) are arranged in the second chamber on a support element which projects into the first chamber via a housing feed-through, wherein the support element is accommodated mechanically in the first chamber by a plug-in device that electrically connects the electrical cables of the user interfaces (12, 14, 15, 16) and/or the connection elements (10,11), which are carried on the support element, with the individual electronic components (4, 5, 6, 7, 8).
Method for enhancing the adhesion of a layer made of a material M on the surface of a substrate S characterised in that: - the material M is a cross-linkable material by insolation with UV rays, and in that it comprises the following steps: a) depositing on at least one surface of the substrate S a non-polymerised polymerisable composition P comprising at least one molecule F comprising a first reactive group F1 suitable for reacting, by insolation with UV rays, with a reactive group M1 of the surface of the material M, and a second reactive group F2 suitable for forming bonds with the constituent material(s) of the surface of the substrate S, b) depositing, on the layer of the non-polymerised composition P, obtained in step a), a layer made of a non-cross-linked material M, and c) insolating with UV rays the three-layer structure obtained in step b). - the material M is a cross-linkable material by insolation with UV rays, a) depositing on at least one surface of the substrate S a non-polymerised polymerisable composition P comprising at least one molecule F comprising a first reactive group F1 suitable for reacting, by insolation with UV rays, with a reactive group M1 of the surface of the material M, and a second reactive group F2 suitable for forming bonds with the constituent material(s) of the surface of the substrate S, b) depositing, on the layer of the non-polymerised composition P, obtained in step a), a layer made of a non-cross-linked material M, and c) insolating with UV rays the three-layer structure obtained in step b).
Electrosurgical tubular shaft (14; 104) for use with a surgical instrument grip (12; 102) for formation of an electrosurgical tubular shaft instrument (10; 100), the tubular shaft (14; 104) comprising a tube, an electrosurgical tool arranged at the distal end on the tubular shaft (14; 104), at least one electric connection line (68, 70) electrically connected to the tool and extending in the tube, and at least one coupling element arranged at the proximal end on the tubular shaft (14; 104) for interacting with at least one corresponding coupling element of the instrument grip (12; 102) for releasably coupling the instrument grip (12; 102) to the tubular shaft (14; 104), the tubular shaft (14; 104) comprising an electric connection element for an electric energy supply, the electric connection element being arranged at the proximal end on the at least one connection line (68, 70), characterized in that the tube comprises an outlet opening which is arranged distally of the at least one coupling element and through which the at least one connection line (68, 70) issues from the tube.
Straightening device, having two arms (3, 4) which are mounted in a pivotable manner on one another and between which hair/fibres is/are pulled through for straightening purposes, wherein the straightening device has, on at least one arm (3, 4), at least one oscillating straightening element (5, 6), which oscillates such that, when the hair/fibres is/are being pulled through, at least some individual locations of the hair/fibres are repeatedly straightened; characterised in that the at least one straightening element (5, 6) executes an elliptical, round or square oscillatory movement.
A polyethylene having (i) an entanglement molecular weight of 9500 g/mol to 13000 g/mol, wherein the entanglement molecular weight is measured as described in the description, (ii) a melt flow rate ratio (MFRR 21.6/5) of 16 to 25, wherein the melt flow rate ratio is a value obtained by dividing the melt index measured at 190 °C under a load of 21.6 kg by the melt index measured at 190 °C under a load of 5 kg in accordance with ASTM D 1238, and (iii) a molecular weight distribution (Mw/Mn) of 5.5 to 10, measured as described in the description, wherein the polyethylene is an ethylene homopolymer.
A support/functional layer assembly comprising a support made of polymeric material and a functional layer arranged directly on said support, wherein the side of the support facing the functional layer has been subjected to an activation process which simultaneously causes a structural weakening of the support on this side, the activation process having being carried out in such a way that (i) the plane with the lowest strength within the support/functional layer assembly lies within the support material and (ii) the peel force to be overcome when separating the functional layer from the support is 0.1 - 10 N/cm, preferably 0.4 - 10 N/cm.
Human-machine interface for the simultaneous and interactive control of a regulating function of a machine, comprising: - a touch-sensitive screen - a regulating input unit, which is operable independently of the touch-sensitive screen and configured to manually control a regulating function of the machine in dependence on a regulating input, and - a parameter input unit that is operable independently of the regulating input unit and of the touch-sensitive screen, - wherein regulating input unit and parameter input unit are connected to a machine control of the machine by means of a real-time interface, - wherein the parameter input unit, which can be operated independently, is configured to simultaneously manually control, as a function of a parameter input, an regulating parameter of the regulating function which is functionally dependent on the regulating function, and - wherein the human-machine interface comprises a parameter display unit that is arranged together with the parameter input unit and configured to feed back a nominal value or a current value, actually occurring in the machine, of the manually controlled regulating parameter, wherein the parameter display unit comprises a bar graph indicator that is oriented along a longitudinal touch-sensitive surface of the parameter input unit, characterized in that at least laterally or on both sides of the bar graph indicator a modulable illuminated readout is provided by means of which a state of the machine is displayable. - a touch-sensitive screen - a regulating input unit, which is operable independently of the touch-sensitive screen and configured to manually control a regulating function of the machine in dependence on a regulating input, and - a parameter input unit that is operable independently of the regulating input unit and of the touch-sensitive screen, - wherein regulating input unit and parameter input unit are connected to a machine control of the machine by means of a real-time interface, - wherein the parameter input unit, which can be operated independently, is configured to simultaneously manually control, as a function of a parameter input, an regulating parameter of the regulating function which is functionally dependent on the regulating function, and - wherein the human-machine interface comprises a parameter display unit that is arranged together with the parameter input unit and configured to feed back a nominal value or a current value, actually occurring in the machine, of the manually controlled regulating parameter, wherein the parameter display unit comprises a bar graph indicator that is oriented along a longitudinal touch-sensitive surface of the parameter input unit,
Valve with an integrated pressure regulator for a pressurized-gas container comprising a valve body comprising: - a gas circuit for conveying a pressurized gas between a gas inlet and a gas outlet, - gas expansion means, which are arranged on the gas circuit and comprise an expansion valve shutter, which is able to move axially within a first chamber and cooperates with a valve seat, and - a second chamber, which is situated downstream of the first chamber and is in fluidic communication with said first chamber via a connecting channel comprising an inlet orifice arranged in an end wall of the first chamber, and wherein: - a seat element comprising a gas passage is arranged in the end wall of the first chamber such that the gas passage of the seat element and the connecting channel connecting the first chamber to the second chamber are coaxial, and - the valve seat is arranged on the perimeter of the inlet orifice of the gas passage of the seat element, characterized in that a sealing element is arranged between the seat element and the end wall or an internal wall of the first chamber. - a gas circuit for conveying a pressurized gas between a gas inlet and a gas outlet, - gas expansion means, which are arranged on the gas circuit and comprise an expansion valve shutter, which is able to move axially within a first chamber and cooperates with a valve seat, and - a second chamber, which is situated downstream of the first chamber and is in fluidic communication with said first chamber via a connecting channel comprising an inlet orifice arranged in an end wall of the first chamber, - a seat element comprising a gas passage is arranged in the end wall of the first chamber such that the gas passage of the seat element and the connecting channel connecting the first chamber to the second chamber are coaxial, and - the valve seat is arranged on the perimeter of the inlet orifice of the gas passage of the seat element,
An abiraterone acetate-containing composition, wherein the composition comprises abiraterone acetate and a self-microemulsion system, wherein the ratio of the weight percentages of abiraterone acetate to the self-microemulsion system is 4.3%-4.8%: 95.2%-95.7%; and the self-microemulsion system comprises an oil phase and an emulsion phase, and the ratio of the weight percentages of the oil phase and the emulsion phase is 30%-38%: 62%-70%; the oil phase comprises glycerol monolinoleate and medium chain triglyceride; the weight ratio of glycerol monolinoleate to medium chain triglyceride is 2.5-3.63:1; the emulsion phase comprises PEG-40 hydrogenated castor oil and 2-(2-ethoxyethoxy)ethanol; and the weight ratio of PEG-40 hydrogenated castor oil to 2-(2-ethoxyethoxy)ethanol in the emulsion phase is 1:2.25-2.5; and wherein the composition comprises the following components: abiraterone acetate: 4.3-4.8 wt.%; glycerol monolinoleate: 21.4-26.2 wt.%; medium chain triglycerides: 6.2-9.6 wt.%; PEG-40 hydrogenated castor oil: 17.7-19.7 wt.%; and 2-(2-ethoxyethoxy)ethanol: 42.8-47.8 wt.%. the self-microemulsion system comprises an oil phase and an emulsion phase, and the ratio of the weight percentages of the oil phase and the emulsion phase is 30%-38%: 62%-70%; the oil phase comprises glycerol monolinoleate and medium chain triglyceride; the weight ratio of glycerol monolinoleate to medium chain triglyceride is 2.5-3.63:1; the emulsion phase comprises PEG-40 hydrogenated castor oil and 2-(2-ethoxyethoxy)ethanol; and the weight ratio of PEG-40 hydrogenated castor oil to 2-(2-ethoxyethoxy)ethanol in the emulsion phase is 1:2.25-2.5; and wherein the composition comprises the following components: abiraterone acetate: 4.3-4.8 wt.%; glycerol monolinoleate: 21.4-26.2 wt.%; medium chain triglycerides: 6.2-9.6 wt.%; PEG-40 hydrogenated castor oil: 17.7-19.7 wt.%; and 2-(2-ethoxyethoxy)ethanol: 42.8-47.8 wt.%. abiraterone acetate: 4.3-4.8 wt.%; glycerol monolinoleate: 21.4-26.2 wt.%; medium chain triglycerides: 6.2-9.6 wt.%; PEG-40 hydrogenated castor oil: 17.7-19.7 wt.%; and 2-(2-ethoxyethoxy)ethanol: 42.8-47.8 wt.%.
A sound information display device comprising: a plurality of sound collecting units; an information obtaining unit that obtains positional information and sound information of a sound source based on collected sound information of the plurality of sound collecting units; a display data generation unit that generates display data for displaying sound information that is obtained by the information obtaining unit overlaid on a visual image at a position that corresponds to positional information that is obtained by the information obtaining unit within the visual image; and a head-mounted image display unit that displays sound information of a sound source overlaid on the visual image at a position that corresponds to the sound source within the visual image based on display data that is generated by the display data generation unit, characterized in that the plurality of sound collecting units include a plurality of omnidirectional sound collecting units and a plurality of directional sound collecting units and the information obtaining unit obtains first directional information of a sound source based on collected sound information of the plurality of omnidirectional sound collecting units, obtains second directional information of a sound source in disposal positions of the plurality of directional sound collecting units by controlling a directional direction of the plurality of directional sound collecting units based on the first directional information, and obtains positional information of the sound source based on the second directional information. a plurality of sound collecting units; an information obtaining unit that obtains positional information and sound information of a sound source based on collected sound information of the plurality of sound collecting units; a display data generation unit that generates display data for displaying sound information that is obtained by the information obtaining unit overlaid on a visual image at a position that corresponds to positional information that is obtained by the information obtaining unit within the visual image; and a head-mounted image display unit that displays sound information of a sound source overlaid on the visual image at a position that corresponds to the sound source within the visual image based on display data that is generated by the display data generation unit, characterized in that the plurality of sound collecting units include a plurality of omnidirectional sound collecting units and a plurality of directional sound collecting units and the information obtaining unit obtains first directional information of a sound source based on collected sound information of the plurality of omnidirectional sound collecting units, obtains second directional information of a sound source in disposal positions of the plurality of directional sound collecting units by controlling a directional direction of the plurality of directional sound collecting units based on the first directional information, and obtains positional information of the sound source based on the second directional information.
A motorcycle (10, 210) comprising: a single main frame extending rearwardly downward from a head pipe (12, 212); a pair of left and right rear frames (14, 16) extending rearwardly upward from the main frame; a luggage box (27, 251) disposed on the front side of a rear wheel and on the upper side of the rear frames (14, 16); a fuel tank (28, 252) disposed on the upper side of the rear wheel and on the rear side of the luggage box (27, 251); a rear fender provided between the left and right rear frames (14, 16), disposed between the luggage box (27, 251) and the rear wheel, and covering the rear wheel on the front and upper sides of the rear wheel; a fuel supply path (103, 299) for supplying a fuel in the fuel tank (28, 252) to an engine side; and a fuel filter disposed in the course of the fuel supply path (103, 299); wherein the rear fender is so disposed that its front portion faces a rear wall (27c, 251a) of the luggage box (27, 251), the front portion being inclined rearwardly upward so that the distance thereto from the rear wall (27c, 251 a) increases along an upward direction; and the fuel filter is disposed between the rear wall (27c, 251a) of the luggage box (27, 251) and the front portion of the rear fender, characterized in that the rear fender has a protuberant portion which is projected toward the rear wall (27c, 251a) of the luggage box (27, 251) for avoiding interference with the rear wheel, the rear frames (14, 16) are disposed on the left and right sides of the protuberant portion, and the fuel filter is disposed between the protuberant portion and the rear frame (14, 16) and is so disposed that its longitudinal direction is set along an extending direction of the rear frame (14, 16), together with the protuberant portion.
An optical cable (1, 1', 1", 1′′′) for distributed sensing, said optical cable (1, 1', 1", 1 "') extending along a longitudinal axis and comprising: - a loose tube with at least one optical fiber loosely arranged therein; - at least one tight buffered optical fiber; and - a metal tube surrounding the at least one tight buffered optical fiber and the loose tube, wherein the loose tube and the at least one tight buffered optical fiber are laid within the metal tube substantially parallel to the longitudinal axis of the optical cable (1, 1', 1", 1′′′), and wherein the loose tube is arranged within the metal tube so as to define a crescent-shaped space within the metal tube, characterized in that the at least one tight buffered optical fiber is compactly arranged within said crescent-shaped space with no degree of freedom, and wherein the loose tube and the at least one tight buffered optical fiber are in direct contact one another and are in direct contact with an inner wall of the metal tube. - a loose tube with at least one optical fiber loosely arranged therein; - at least one tight buffered optical fiber; and - a metal tube surrounding the at least one tight buffered optical fiber and the loose tube, wherein the loose tube and the at least one tight buffered optical fiber are laid within the metal tube substantially parallel to the longitudinal axis of the optical cable (1, 1', 1", 1′′′), and wherein the loose tube is arranged within the metal tube so as to define a crescent-shaped space within the metal tube, characterized in that the at least one tight buffered optical fiber is compactly arranged within said crescent-shaped space with no degree of freedom, and wherein the loose tube and the at least one tight buffered optical fiber are in direct contact one another and are in direct contact with an inner wall of the metal tube.