mhurhangee/ep-ind-claims huggingface dataset:
An acellular pro-tolerogenic conditioned preparation comprising miRNA species and lacking components having an average molecular weight or more than about 10kDa for use to treat, prevent and/or alleviate an auto-immune disease afflicting a subject by increasing a ratio of the level of regulatory T (Treg) cells to the level of pro-inflammatory T cells in a subject, wherein the acellular pro-tolerogenic conditioned preparation has been obtained by a process comprising: (i) associating a low-immunogenic biocompatible polymer to a cytoplasmic membrane of a first leukocyte to obtain a first modified leukocyte, wherein the low-immunogenic biocompatible polymer is polyethylene glycol, 2-alkyloxazoline or hyperbranched polyglycerol; (ii) contacting the first modified leukocyte with a second leukocyte under conditions to allow a pro-tolerogenic allo-recognition to provide a conditioned preparation, wherein the first leukocyte is allogeneic to the second leukocyte; (iii) removing the first modified leukocyte, the second leukocyte and components having an average molecular weight or more than about 10kDa from the conditioned preparation under conditions to inhibit RNA degradation to enrich the miRNA species in the conditioned preparation and to maintain the relative abundance of each of the miRNA species so as to obtain a composition enriched in miRNAs species; and (iv) formulating the composition of step (iii), under conditions to inhibit RNA degradation and to maintain the relative abundance of each of the miRNA species, in the pro-tolerogenic preparation for administration to the subject. (i) associating a low-immunogenic biocompatible polymer to a cytoplasmic membrane of a first leukocyte to obtain a first modified leukocyte, wherein the low-immunogenic biocompatible polymer is polyethylene glycol, 2-alkyloxazoline or hyperbranched polyglycerol; (ii) contacting the first modified leukocyte with a second leukocyte under conditions to allow a pro-tolerogenic allo-recognition to provide a conditioned preparation, wherein the first leukocyte is allogeneic to the second leukocyte; (iii) removing the first modified leukocyte, the second leukocyte and components having an average molecular weight or more than about 10kDa from the conditioned preparation under conditions to inhibit RNA degradation to enrich the miRNA species in the conditioned preparation and to maintain the relative abundance of each of the miRNA species so as to obtain a composition enriched in miRNAs species; and (iv) formulating the composition of step (iii), under conditions to inhibit RNA degradation and to maintain the relative abundance of each of the miRNA species, in the pro-tolerogenic preparation for administration to the subject.
An apparatus for contacting a fluid stream with microorganisms, the apparatus comprising: a housing having a contacting chamber therein defined by a wall of the housing, wherein the contact chamber has a first region, in use the first region being occupied by a liquid medium containing microorganisms, and a second region, in use the second region being occupied by fluid from the fluid stream to be processed; a first inlet for the fluid stream to be treated, the inlet directing fluid to be processed into the second region of the contacting chamber; a first outlet for removing a liquid culture medium stream containing microorganisms; a second outlet for the fluid stream to be treated; a rotor assembly comprising an impeller moveable within the contacting chamber to promote contact between the fluid stream being treated and the liquid culture medium within the contacting chamber, in use the impeller moving through both the first and second regions of the contact chamber; wherein the impeller comprises at least one scoop or bucket to transport a portion of the microorganism-containing liquid medium into the region of the housing occupied by the fluid stream to be treated and in turn transport fluid from the fluid stream to be treated into the microorganism-containing liquid medium; wherein at a least a portion of the wall of the housing defining the contacting chamber is transparent to light. a housing having a contacting chamber therein defined by a wall of the housing, wherein the contact chamber has a first region, in use the first region being occupied by a liquid medium containing microorganisms, and a second region, in use the second region being occupied by fluid from the fluid stream to be processed; a first inlet for the fluid stream to be treated, the inlet directing fluid to be processed into the second region of the contacting chamber; a first outlet for removing a liquid culture medium stream containing microorganisms; a second outlet for the fluid stream to be treated; a rotor assembly comprising an impeller moveable within the contacting chamber to promote contact between the fluid stream being treated and the liquid culture medium within the contacting chamber, in use the impeller moving through both the first and second regions of the contact chamber; wherein the impeller comprises at least one scoop or bucket to transport a portion of the microorganism-containing liquid medium into the region of the housing occupied by the fluid stream to be treated and in turn transport fluid from the fluid stream to be treated into the microorganism-containing liquid medium; wherein at a least a portion of the wall of the housing defining the contacting chamber is transparent to light.
A process for the synthesis of methane (CH 4; SNG, Substitute Natural Gas) and/or methanol (CH 3 OH) by hydrogenation of CO and/or CO 2 with hydrogen, comprising following process steps: a) providing a reactor system with (a-a) a three-phase reactor operated in countercurrent process, as well as (a-b) a reactor for hydrogenation of a heat transfer medium and optionally a storage tank or reservoir for a hydrogenated heat transfer medium (a-c) and/or optionally a storage tank or reservoir for an unhydrogenated heat transfer medium (a-d); b) charging the three-phase reactor (a-a) with a catalytic charge; c-a) hydrogenation of the heat transfer medium in reactor (a-b), c) continuously introducing the hydrogenated heat transfer medium into the three-phase reactor (a-a) in the form of a liquid phase, wherein the hydrogen is chemically bound to the heat transfer medium; d) introducing CO and/or CO 2 into the three-phase reactor (a-a); and e) discharging the reacted synthesis products. a) providing a reactor system with (a-a) a three-phase reactor operated in countercurrent process, as well as (a-b) a reactor for hydrogenation of a heat transfer medium and optionally a storage tank or reservoir for a hydrogenated heat transfer medium (a-c) and/or optionally a storage tank or reservoir for an unhydrogenated heat transfer medium (a-d); (a-a) a three-phase reactor operated in countercurrent process, as well as (a-b) a reactor for hydrogenation of a heat transfer medium and optionally a storage tank or reservoir for a hydrogenated heat transfer medium (a-c) and/or optionally a storage tank or reservoir for an unhydrogenated heat transfer medium (a-d); b) charging the three-phase reactor (a-a) with a catalytic charge; c-a) hydrogenation of the heat transfer medium in reactor (a-b), c) continuously introducing the hydrogenated heat transfer medium into the three-phase reactor (a-a) in the form of a liquid phase, wherein the hydrogen is chemically bound to the heat transfer medium; d) introducing CO and/or CO 2 into the three-phase reactor (a-a); and e) discharging the reacted synthesis products.
A fuel oil composition comprising a major amount of a fuel oil and a minor amount of a compound being the product of the 1,4-addition reaction of (i) ammonia, a primary or secondary hydrocarbyl-substituted amine or a mixture thereof to (ii) a species containing one or more α,β-unsaturated carbonyl groups, wherein the compound includes at least one alkyl or alkenyl group containing from at least 12 carbon atoms.
A strain detector comprising: a strain-causing portion configured to cause a strain in response to an external stress; an insulation film formed on at least a part of the strain-causing portion; a strain gauge formed on the insulation film, the strain gauge being configured to detect the strain caused by the strain-causing portion as an electric signal; an electrode connected to the strain gauge; a bonding pad extended from the electrode and configured to export the electric signal to an outside; a bonding wire connected to the bonding pad; and a protection film disposed on the insulation film, the strain gauge and the electrode, the protection film being formed from a silicon oxide film or silicon nitride film, characterized in that an insulative resin layer (17, 27) at least covers the strain gauge and the protection film without covering the bonding pad and the bonding wire, the insulative resin layer (17, 27) being formed from a silicone resin and having a Shore A hardness ranging from 10 to 100. a strain-causing portion configured to cause a strain in response to an external stress; an insulation film formed on at least a part of the strain-causing portion; a strain gauge formed on the insulation film, the strain gauge being configured to detect the strain caused by the strain-causing portion as an electric signal; an electrode connected to the strain gauge; a bonding pad extended from the electrode and configured to export the electric signal to an outside; a bonding wire connected to the bonding pad; and a protection film disposed on the insulation film, the strain gauge and the electrode, the protection film being formed from a silicon oxide film or silicon nitride film, characterized in that an insulative resin layer (17, 27) at least covers the strain gauge and the protection film without covering the bonding pad and the bonding wire, the insulative resin layer (17, 27) being formed from a silicone resin and having a Shore A hardness ranging from 10 to 100.
A method of providing a cell culture enriched for GABAergic interneurons, the method comprising: a) providing primate pluripotent stem (pPS) cells in a culture medium; b) introducing to the culture medium, factors comprising: i) an activator of the sonic hedgehog (shh) pathway, ii) a SMAD inhibitor, iii) a wnt pathway inhibitor, iv) a neural inducing supplement, and v) a Notch pathway inhibitor; wherein steps a) and b) result in a cell culture enriched in GABAergic interneurons. a) providing primate pluripotent stem (pPS) cells in a culture medium; b) introducing to the culture medium, factors comprising: i) an activator of the sonic hedgehog (shh) pathway, ii) a SMAD inhibitor, iii) a wnt pathway inhibitor, iv) a neural inducing supplement, and v) a Notch pathway inhibitor; i) an activator of the sonic hedgehog (shh) pathway, ii) a SMAD inhibitor, iii) a wnt pathway inhibitor, iv) a neural inducing supplement, and v) a Notch pathway inhibitor;
A method for separating pancreatic islets from a pancreas tissue, using a degrading-enzyme composition, which is prepared by adding collagenase H and collagenase G derived from Clostridium sp. in an amount sufficient to degrade collagen I and/or collagen III and in accordance with the composition of collagen I and/or collagen III of the pancreas tissue, to a predetermined amount of a neutral protease and/or a protease derived from Clostridium sp., wherein collagenase H degrades collagen I and collagen III, and wherein the weight ratio (H/G) of collagenase H and collagenase G in the degrading-enzyme composition is 0.35 or more.
An implantable device, comprising: a memory that stores executable components; and a processor that executes the executable components stored in the memory, wherein the executable components comprise: a communication component configured to transmit one or more packets on a communication network; a packet transmission queue configured to store the one or more packets for transmission on the communication network; a data management queue configured to store one or more data items for submission to the packet transmission queue to one or more other devices; and a data removal component configured to remove a data item of the one or more data items from the data management queue, wherein removal is based on a determination that the data item in the data management queue has an expected arrival time to another device of the one or more other devices that exceeds a latest arrival time associated with the data item. a memory that stores executable components; and a processor that executes the executable components stored in the memory, wherein the executable components comprise: a communication component configured to transmit one or more packets on a communication network; a packet transmission queue configured to store the one or more packets for transmission on the communication network; a data management queue configured to store one or more data items for submission to the packet transmission queue to one or more other devices; and a data removal component configured to remove a data item of the one or more data items from the data management queue, wherein removal is based on a determination that the data item in the data management queue has an expected arrival time to another device of the one or more other devices that exceeds a latest arrival time associated with the data item. a communication component configured to transmit one or more packets on a communication network; a packet transmission queue configured to store the one or more packets for transmission on the communication network; a data management queue configured to store one or more data items for submission to the packet transmission queue to one or more other devices; and a data removal component configured to remove a data item of the one or more data items from the data management queue, wherein removal is based on a determination that the data item in the data management queue has an expected arrival time to another device of the one or more other devices that exceeds a latest arrival time associated with the data item.
A method for isolating poly nucleic acids having a single stranded poly stretch from a nucleic acid containing sample comprising: (a) providing a hybridization composition comprising: i) a nucleic acid containing sample; ii) a hybridization solution comprising: aa. a sodium salt; bb. a quaternary ammonium salt; wherein the components of the hybridization solution can be added as single solution to the sample or may be added separately in any order to the sample; iii) a capture probe capable of hybridizing to the poly stretch of the poly nucleic acids; and incubating said hybridization composition under conditions to form nucleic acid-hybrids between the poly nucleic acids and the capture probe; (b) separating the formed hybrids from the remaining sample. (a) providing a hybridization composition comprising: i) a nucleic acid containing sample; ii) a hybridization solution comprising: aa. a sodium salt; bb. a quaternary ammonium salt; wherein the components of the hybridization solution can be added as single solution to the sample or may be added separately in any order to the sample; iii) a capture probe capable of hybridizing to the poly stretch of the poly nucleic acids; and incubating said hybridization composition under conditions to form nucleic acid-hybrids between the poly nucleic acids and the capture probe; i) a nucleic acid containing sample; ii) a hybridization solution comprising: aa. a sodium salt; bb. a quaternary ammonium salt; wherein the components of the hybridization solution can be added as single solution to the sample or may be added separately in any order to the sample; aa. a sodium salt; bb. a quaternary ammonium salt; iii) a capture probe capable of hybridizing to the poly stretch of the poly nucleic acids; (b) separating the formed hybrids from the remaining sample.
A combustor for a gas turbine engine comprising: a support shell (68,70) with a shell coating applied thereto; and a multiple of liner panels (72,74) circumferentially mounted within the support shell (68,70) via a multiple of studs, each of the multiple of liner panels (72,74) having a liner coating applied thereto; characterised in that: the shell coating is about one-half the thickness of the liner coating; and the shell coating is locally applied to at least one of a dilution hole region, an igniter hole region, a turbine vane upstream region upstream of each Nozzle Guide Vane, and a panel interface region. a support shell (68,70) with a shell coating applied thereto; and a multiple of liner panels (72,74) circumferentially mounted within the support shell (68,70) via a multiple of studs, each of the multiple of liner panels (72,74) having a liner coating applied thereto; the shell coating is about one-half the thickness of the liner coating; and the shell coating is locally applied to at least one of a dilution hole region, an igniter hole region, a turbine vane upstream region upstream of each Nozzle Guide Vane, and a panel interface region.
A needle guard couplable to a syringe comprising: - a lock collar couplable to a neck of the syringe, - a device shield which includes one or more lockout arms, and - a flexible member interconnecting the lock collar and the device shield, wherein the device shield is movable relative to the lock collar from a first configuration where the device shield is free to retract proximally to expose a syringe sharp to a second configuration where the device shield is fixed in a position covering the syringe sharp, wherein the device shield is caused to disengage from the first configuration as the device shield moves proximally enabling the device shield to move distally under the bias of the flexible member to the second configuration; characterized in that the lock collar includes one or more recesses, wherein the one or more lockout arms engage the one or more recesses to retain the device shield in the second configuration, and wherein the one or more lockout arms is configured to ride distally down a lip in the lock collar, during the distal movement of the device shield to the second configuration, until encountering the one or more recesses and snapping into it due to its flexed state. - a lock collar couplable to a neck of the syringe, - a device shield which includes one or more lockout arms, and - a flexible member interconnecting the lock collar and the device shield, wherein the device shield is movable relative to the lock collar from a first configuration where the device shield is free to retract proximally to expose a syringe sharp to a second configuration where the device shield is fixed in a position covering the syringe sharp, wherein the device shield is caused to disengage from the first configuration as the device shield moves proximally enabling the device shield to move distally under the bias of the flexible member to the second configuration;
A granule comprising a core and a coating, wherein the core comprises an active compound, and the coating comprises filaments prepared from atomizing a liquid coating composition which comprises polyvinyl pyrrolidone or polyvinyl alcohol and has the property that said liquid coating composition forms filaments upon atomization during coating of the cores.
Method for determining a gear rack force of a steer-by-wire steering system, wherein the steering system comprises: - a steering handle, by way of which a steering angle can be specified as a function of a steering handle position; - a vehicle wheel actuator, which is designed to set the steering angle by moving a gear rack of the steering system, the gear rack being coupled to at least one vehicle wheel, by applying an actuating force; - a reaction force actuator, by way of which a reaction force on the steering handle can be produced in accordance with a gear rack force; characterized in that the method comprises: - determining friction operation, in which gear rack movement does not occur when the steering handle position changes, and, if friction operation is present: - determining the gear rack force on the basis of the actuating force of the vehicle wheel actuator, wherein, when friction operation is present, the gear rack force is set equal to the actuating force of the vehicle wheel actuator, and - generating the reaction force in accordance with this gear rack force. - a steering handle, by way of which a steering angle can be specified as a function of a steering handle position; - a vehicle wheel actuator, which is designed to set the steering angle by moving a gear rack of the steering system, the gear rack being coupled to at least one vehicle wheel, by applying an actuating force; - a reaction force actuator, by way of which a reaction force on the steering handle can be produced in accordance with a gear rack force; - determining friction operation, in which gear rack movement does not occur when the steering handle position changes, and, if friction operation is present: - determining the gear rack force on the basis of the actuating force of the vehicle wheel actuator, wherein, when friction operation is present, the gear rack force is set equal to the actuating force of the vehicle wheel actuator, and - generating the reaction force in accordance with this gear rack force. - determining the gear rack force on the basis of the actuating force of the vehicle wheel actuator, wherein, when friction operation is present, the gear rack force is set equal to the actuating force of the vehicle wheel actuator, and - generating the reaction force in accordance with this gear rack force.
Method for calibrating the orientation of a longitudinal axis (x sensor) and a transverse axis (y sensor) of an acceleration sensor provided in a vehicle having a coordinate system made up of the longitudinal axis (x sensor), the transverse axis (y sensor) and a vertical axis (z sensor), wherein the axes are each perpendicular to one another, having the following steps: measuring the acceleration along the longitudinal and transverse axis (x sensor and y sensor) of the sensor during a braking procedure of the vehicle at low velocity and at a standstill over the time curve, determining an offset vector (a o) at a standstill, which is composed of a component in the direction of the longitudinal axis (x sensor) and a component in the direction of the transverse axis (y sensor) of the sensor and represents the influence of the gravitational acceleration on the measured acceleration of the vehicle, ascertaining at least one resulting acceleration vector (a r) by subtracting the offset vector (a o) from the at least one measured acceleration vector (a t) which is composed of a measured acceleration in the direction of each of the longitudinal and transverse axes (xsensor and y sensor) at a point in time, transforming the coordinate system of the sensor, so that the at least one resulting acceleration vector (a r) points in the vehicle longitudinal direction. measuring the acceleration along the longitudinal and transverse axis (x sensor and y sensor) of the sensor during a braking procedure of the vehicle at low velocity and at a standstill over the time curve, determining an offset vector (a o) at a standstill, which is composed of a component in the direction of the longitudinal axis (x sensor) and a component in the direction of the transverse axis (y sensor) of the sensor and represents the influence of the gravitational acceleration on the measured acceleration of the vehicle, ascertaining at least one resulting acceleration vector (a r) by subtracting the offset vector (a o) from the at least one measured acceleration vector (a t) which is composed of a measured acceleration in the direction of each of the longitudinal and transverse axes (xsensor and y sensor) at a point in time, transforming the coordinate system of the sensor, so that the at least one resulting acceleration vector (a r) points in the vehicle longitudinal direction.