Transcranial fastening device for at least one drainage catheter, comprising: - at least one external body adapted to be inserted inside a transcranial drilling hole, said external body being equipped with at least one passage for said drainage catheter, said passage being equipped with blocking means of said drainage catheter adapted to allow a sliding of said drainage catheter through said passage along a first movement direction (M 1) and to prevent a sliding of said drainage catheter through said passage along a second movement direction (M 2); - at least one actuating means operatively cooperating with said blocking means and being adapted to be moved from a first operating position in which said blocking means do not allow the sliding of said drainage catheter through said passage along said second movement direction (M 2) to a second operating position in which said blocking means allow the sliding of said drainage catheter through said passage along said second movement direction (M 2), wherein said device comprises at least one abutment profile radially arranged around said external body in order to about against an external surface of a skullcap adjacent to said drilling hole, characterized in that said blocking means comprise a plurality of unidirectional flexible wings radially arranged around said passage of said external body and suitably oriented in such a way as to offer a flexure in favor of the sliding of said drainage catheter along said first movement direction (M 1) through said passage and, without the intervention of said actuating means which are in their first operating position, to be stopped dead on a external surface of said drainage catheter to prevent the sliding of said drainage catheter along said second movement direction (M 2) through said passage. - at least one external body adapted to be inserted inside a transcranial drilling hole, said external body being equipped with at least one passage for said drainage catheter, said passage being equipped with blocking means of said drainage catheter adapted to allow a sliding of said drainage catheter through said passage along a first movement direction (M 1) and to prevent a sliding of said drainage catheter through said passage along a second movement direction (M 2); - at least one actuating means operatively cooperating with said blocking means and being adapted to be moved from a first operating position in which said blocking means do not allow the sliding of said drainage catheter through said passage along said second movement direction (M 2) to a second operating position in which said blocking means allow the sliding of said drainage catheter through said passage along said second movement direction (M 2), wherein said device comprises at least one abutment profile radially arranged around said external body in order to about against an external surface of a skullcap adjacent to said drilling hole, characterized in that said blocking means comprise a plurality of unidirectional flexible wings radially arranged around said passage of said external body and suitably oriented in such a way as to offer a flexure in favor of the sliding of said drainage catheter along said first movement direction (M 1) through said passage and, without the intervention of said actuating means which are in their first operating position, to be stopped dead on a external surface of said drainage catheter to prevent the sliding of said drainage catheter along said second movement direction (M 2) through said passage.