A compound of Formula, or a pharmaceutically acceptable salt thereof, wherein, R 2 is selected from CH 3, CH 2 CH 3, CH 2 CF 3, CH 2 F, CHF 2, CF 3, CH 2 D, CHD 2, or CD 3; X5 is C-R 5 or N; X6 is C-R 6 or N; X7 is C-R 7 or N; X8 is C-R 8 or N; wherein no more than two of X5, X6, X7, or X8 may be N; R 5 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 6 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 7 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 8 is hydrogen, halogen, or alkyl; R A is X2 is N or C-R 12, wherein R 12 is hydrogen, halogen, alkyl, or alkoxy; R 13 is -Y-Z; Y is selected from a bond, -CH 2 -, or -CH(C 1 -C 4 alkyl)-; Z is selected from -SO 2 R 21, -N(R 22)SO 2 R 21, -SO 2 N(R 22) 2, -N(R 22)SO 2 N(R 22) 2,-CON(R 22) 2, -N(R 22)CO 2 R 21, -N(R 22)CON(R 22) 2, -N(R 22)COR 21, -COR 21, -OC N(R 22) 2, -OSO 2 N(R 22) 2, or -N(R 22)SO 3 R 21; X3 is N or C-R 14, wherein R 14 is hydrogen, halogen, -CN, alkyl, cycloalkyl, or alkoxy; X4 is N or C-R 15, wherein R 15 is hydrogen, halogen, alkyl, -CN, or alkoxy; R 16 is hydrogen, halogen, -N COX, or -W-X, wherein W is a bond, -O-, -S-, or -NH-, and X is selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkynyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; each R 21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and each R 22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl. R 2 is selected from CH 3, CH 2 CH 3, CH 2 CF 3, CH 2 F, CHF 2, CF 3, CH 2 D, CHD 2, or CD 3; X5 is C-R 5 or N; X6 is C-R 6 or N; X7 is C-R 7 or N; X8 is C-R 8 or N; wherein no more than two of X5, X6, X7, or X8 may be N; R 5 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 6 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 7 is hydrogen, halogen, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 8 is hydrogen, halogen, or alkyl; R A is X2 is N or C-R 12, wherein R 12 is hydrogen, halogen, alkyl, or alkoxy; R 13 is -Y-Z; Y is selected from a bond, -CH 2 -, or -CH(C 1 -C 4 alkyl)-; Z is selected from -SO 2 R 21, -N(R 22)SO 2 R 21, -SO 2 N(R 22) 2, -N(R 22)SO 2 N(R 22) 2,-CON(R 22) 2, -N(R 22)CO 2 R 21, -N(R 22)CON(R 22) 2, -N(R 22)COR 21, -COR 21, -OC N(R 22) 2, -OSO 2 N(R 22) 2, or -N(R 22)SO 3 R 21; X3 is N or C-R 14, wherein R 14 is hydrogen, halogen, -CN, alkyl, cycloalkyl, or alkoxy; X4 is N or C-R 15, wherein R 15 is hydrogen, halogen, alkyl, -CN, or alkoxy; R 16 is hydrogen, halogen, -N COX, or -W-X, wherein W is a bond, -O-, -S-, or -NH-, and X is selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkynyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; each R 21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and each R 22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl.