A signal interference handling method, suitable to be executed in a home base station, HBS, of a cellular system, the signal interference handling method comprising: receiving, at the HBS, an interference mitigation request, IM request; and the HBS entering a low duty mode, LDM, after the HBS receives the IM request, wherein the IM request is sent by a mobile station, m-MS, served by a macro or micro cell base station of the cellular system when the m-MS detects there is mutual interference, wherein the method further comprises: setting, at the HBS, an activating-deactivating pattern and a LDM duration of a LDM setting before the HBS enters the LDM, wherein the LDM duration is an operation time of the LDM, and the LDM activating-deactivating pattern represents an interlaced distribution of activating periods and deactivating periods in the LDM duration, characterized by: detecting, at the HBS, whether the LDM duration is ended; the HBS returning to a normal mode or continually operating in the LDM when the LDM duration is ended; detecting, at the HBS, whether the IM request is received during the activating period when the LDM is not ended; the HBS continually operating in the LDM when the HBS does not receive IM request during the activating period; detecting, at the HBS, whether the LDM setting is required to be adjusted when the HBS receives IM request during the activating period; and reconfiguring, at the HBS, the activating-deactivating pattern and the LDM duration, and entering the LDM with the latest LDM setting after the reconfiguration when the LDM setting is required to be adjusted. receiving, at the HBS, an interference mitigation request, IM request; and the HBS entering a low duty mode, LDM, after the HBS receives the IM request, wherein the IM request is sent by a mobile station, m-MS, served by a macro or micro cell base station of the cellular system when the m-MS detects there is mutual interference, wherein the method further comprises: setting, at the HBS, an activating-deactivating pattern and a LDM duration of a LDM setting before the HBS enters the LDM, wherein the LDM duration is an operation time of the LDM, and the LDM activating-deactivating pattern represents an interlaced distribution of activating periods and deactivating periods in the LDM duration, characterized by: detecting, at the HBS, whether the LDM duration is ended; the HBS returning to a normal mode or continually operating in the LDM when the LDM duration is ended; detecting, at the HBS, whether the IM request is received during the activating period when the LDM is not ended; the HBS continually operating in the LDM when the HBS does not receive IM request during the activating period; detecting, at the HBS, whether the LDM setting is required to be adjusted when the HBS receives IM request during the activating period; and reconfiguring, at the HBS, the activating-deactivating pattern and the LDM duration, and entering the LDM with the latest LDM setting after the reconfiguration when the LDM setting is required to be adjusted. setting, at the HBS, an activating-deactivating pattern and a LDM duration of a LDM setting before the HBS enters the LDM, wherein the LDM duration is an operation time of the LDM, and the LDM activating-deactivating pattern represents an interlaced distribution of activating periods and deactivating periods in the LDM duration, characterized by: detecting, at the HBS, whether the LDM duration is ended; the HBS returning to a normal mode or continually operating in the LDM when the LDM duration is ended; detecting, at the HBS, whether the IM request is received during the activating period when the LDM is not ended; the HBS continually operating in the LDM when the HBS does not receive IM request during the activating period; detecting, at the HBS, whether the LDM setting is required to be adjusted when the HBS receives IM request during the activating period; and reconfiguring, at the HBS, the activating-deactivating pattern and the LDM duration, and entering the LDM with the latest LDM setting after the reconfiguration when the LDM setting is required to be adjusted. detecting, at the HBS, whether the LDM duration is ended; the HBS returning to a normal mode or continually operating in the LDM when the LDM duration is ended; detecting, at the HBS, whether the IM request is received during the activating period when the LDM is not ended; the HBS continually operating in the LDM when the HBS does not receive IM request during the activating period; detecting, at the HBS, whether the LDM setting is required to be adjusted when the HBS receives IM request during the activating period; and reconfiguring, at the HBS, the activating-deactivating pattern and the LDM duration, and entering the LDM with the latest LDM setting after the reconfiguration when the LDM setting is required to be adjusted.