A 3D bioprinter (1, 1', 1") comprising a base unit, the base unit comprising a support adapted for mounting of at least one toolhead (4, 4', 4", 4′′′), wherein the support comprises a support part adapted for mounting of at least one exchangeable toolhead (4, 4', 4", 4′′′), the base unit further comprising a communication interface part for communication with the at least one toolhead (4, 4', 4", 4′′′), when mounted, and the base unit further comprising a base unit processing element adapted to communicate with the at least one toolhead over said communication interface part, wherein the base unit processing element is arranged to obtain over the communication interface part information related to characteristics associated to the at least one exchangeable toolhead (4, 4', 4", 4′′′) from a toolhead processing element of the at least one exchangeable toolhead (4,4', 4", 4'"), when the exchangeable toolhead (4, 4', 4", 4′′′) is mounted on the support of the base unit, characterized in that the characteristics associated to the at least one exchangeable toolhead (4, 4', 4", 4′′′) comprises information related to at least one of I) actuator type such as printing technology of the exchangeable toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a pneumatic extrusion toolhead, syringe pump toolhead, inkjet toolhead, high temperature extrusion tool head, a tool head for removal of material and/or curing toolhead, or II) a sensor technology of the toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a camera toolhead, probing toolhead and/or 3D scanning toolhead, and wherein the support is adapted to accommodate a plurality of toolheads (4, 4', 4", 4′′′) simultaneously. the base unit comprising a support adapted for mounting of at least one toolhead (4, 4', 4", 4′′′), wherein the support comprises a support part adapted for mounting of at least one exchangeable toolhead (4, 4', 4", 4′′′), the base unit further comprising a communication interface part for communication with the at least one toolhead (4, 4', 4", 4′′′), when mounted, and the base unit further comprising a base unit processing element adapted to communicate with the at least one toolhead over said communication interface part, wherein the base unit processing element is arranged to obtain over the communication interface part information related to characteristics associated to the at least one exchangeable toolhead (4, 4', 4", 4′′′) from a toolhead processing element of the at least one exchangeable toolhead (4,4', 4", 4'"), when the exchangeable toolhead (4, 4', 4", 4′′′) is mounted on the support of the base unit, characterized in that the characteristics associated to the at least one exchangeable toolhead (4, 4', 4", 4′′′) comprises information related to at least one of I) actuator type such as printing technology of the exchangeable toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a pneumatic extrusion toolhead, syringe pump toolhead, inkjet toolhead, high temperature extrusion tool head, a tool head for removal of material and/or curing toolhead, or II) a sensor technology of the toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a camera toolhead, probing toolhead and/or 3D scanning toolhead, and I) actuator type such as printing technology of the exchangeable toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a pneumatic extrusion toolhead, syringe pump toolhead, inkjet toolhead, high temperature extrusion tool head, a tool head for removal of material and/or curing toolhead, or II) a sensor technology of the toolhead (4, 4', 4", 4′′′), said information defining that the exchangeable toolhead (4, 4', 4", 4′′′) is a camera toolhead, probing toolhead and/or 3D scanning toolhead, wherein the support is adapted to accommodate a plurality of toolheads (4, 4', 4", 4′′′) simultaneously.