A method for preparing a 4'-O-methylated cinnamic acid amide using a recombinant microorganism or fungus comprising the following steps: (i) providing a recombinant microorganism or fungus comprising - a nucleic acid section comprising or consisting of at least one gene encoding a 4'-O-methyltransferase, and - optionally a nucleic acid section comprising or consisting of at least one gene encoding a 3'-O-methyltransferase, and - (b) optionally a nucleic acid section for the fermentative production, comprising or consisting of a gene encoding a S-adenosylmethionine synthase; and additionally providing a recombinant microorganism or fungus containing - (c) a nucleic acid section comprising or consisting of at least one gene encoding a 4-coumarate:CoA ligase, and - (d) a nucleic acid section comprising or consisting of at least one gene encoding a tyramine N-hydroxycinnamoyltransferase, and - (e) optionally a nucleic acid portion comprising or consisting of a gene encoding a DOPA decarboxylase, (ii) cultivating the recombinant microorganism or fungus under conditions allowing the expression of the nucleic acid sections for obtaining the corresponding expression products; (iii) optionally: isolating as well as optionally purifying the obtained expression products; (iv) adding dopamine and/or L-dihydroxyphenylalanine, tyrosine and/or phenylalanine and a hydroxycinnamic acid to the at least one cultured recombinant microorganism or fungus according to step (ii) for fermentative conversion, or adding a phenethylamine and a cinnamic acid ester to the expression products according to step (iii) for enzymatic conversion; and (v) cultivating or incubating the recombinant microorganism or fungus or the expression products, optionally by adding a lipase, under conditions which allow the conversion of dopamine and/or L-Dihydroxyphenylalanine and of a hydroxycinnamic acid to a 4'-O-methylated cinnamic acid amide; (vi) optionally isolating and optionally purifying the resulting 4'-O-methylated cinnamic acid amide, and optionally, if present, other by-products. (i) providing a recombinant microorganism or fungus comprising - a nucleic acid section comprising or consisting of at least one gene encoding a 4'-O-methyltransferase, and - optionally a nucleic acid section comprising or consisting of at least one gene encoding a 3'-O-methyltransferase, and - (b) optionally a nucleic acid section for the fermentative production, comprising or consisting of a gene encoding a S-adenosylmethionine synthase; and additionally providing a recombinant microorganism or fungus containing - (c) a nucleic acid section comprising or consisting of at least one gene encoding a 4-coumarate:CoA ligase, and - (d) a nucleic acid section comprising or consisting of at least one gene encoding a tyramine N-hydroxycinnamoyltransferase, and - (e) optionally a nucleic acid portion comprising or consisting of a gene encoding a DOPA decarboxylase, - a nucleic acid section comprising or consisting of at least one gene encoding a 4'-O-methyltransferase, and - optionally a nucleic acid section comprising or consisting of at least one gene encoding a 3'-O-methyltransferase, and - (b) optionally a nucleic acid section for the fermentative production, comprising or consisting of a gene encoding a S-adenosylmethionine synthase; and additionally providing a recombinant microorganism or fungus containing - (c) a nucleic acid section comprising or consisting of at least one gene encoding a 4-coumarate:CoA ligase, and - (d) a nucleic acid section comprising or consisting of at least one gene encoding a tyramine N-hydroxycinnamoyltransferase, and - (e) optionally a nucleic acid portion comprising or consisting of a gene encoding a DOPA decarboxylase, (ii) cultivating the recombinant microorganism or fungus under conditions allowing the expression of the nucleic acid sections for obtaining the corresponding expression products; (iii) optionally: isolating as well as optionally purifying the obtained expression products; (iv) adding dopamine and/or L-dihydroxyphenylalanine, tyrosine and/or phenylalanine and a hydroxycinnamic acid to the at least one cultured recombinant microorganism or fungus according to step (ii) for fermentative conversion, or adding a phenethylamine and a cinnamic acid ester to the expression products according to step (iii) for enzymatic conversion; and (v) cultivating or incubating the recombinant microorganism or fungus or the expression products, optionally by adding a lipase, under conditions which allow the conversion of dopamine and/or L-Dihydroxyphenylalanine and of a hydroxycinnamic acid to a 4'-O-methylated cinnamic acid amide; (vi) optionally isolating and optionally purifying the resulting 4'-O-methylated cinnamic acid amide, and optionally, if present, other by-products.