A compound represented by formula, a pharmaceutically acceptable salt or a tautomer thereof, wherein, T is selected from N or CH; R 1 is selected from H, or selected from the group consisting of C 1-6 alkyl and C 1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; each of R 2, R 3 is independently selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or independently selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 2 and R 3 are linked together to form C 3-6 cycloalkyl or 3 to 6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 4 is selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 5 is selected from H, F, Cl, Br, I, OH, CN, NH 2, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 6 is selected from H, F, Cl, Br, I, OH, CN, NH 2, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 5 and R 6 are linked together to form C 3-6 cycloalkyl or 3 to 6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2 or 3 of R; L is selected from a single bond, -C(=O)O-, -C(=O)NH-; L 1 is selected from a single bond, -NH-; R 7 is selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 3 to 6 membered heterocycloalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 6 and R 7 are linked together to form C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; R is selected from F, Cl, Br, I, OH, CN, NH 2, COOH, C(=O)NH 2, or selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl and 3 to 6 membered heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R'; the moiety is R' is selected from F, Cl, Br, I, OH, CN, NH 2, COOH, Me, Et, CF 3, CHF 2, CH 2 F, NHCH 3, N(CH 3) 2; "hetero" refers to a heteroatom or a heteroatomic group, which is selected from the group consisting of -C(=O)NH-, -NH-, -C(=NH)-, -S(=O) 2 NH-, -S(=O)NH-, -O-, -S-, =O, =S, -O-N=, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) 2 - and -NHC(=O)NH-; in any case above, the number of the heteroatom or the heteroatomic group is independently selected from 1, 2 or 3, respectively. T is selected from N or CH; R 1 is selected from H, or selected from the group consisting of C 1-6 alkyl and C 1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; each of R 2, R 3 is independently selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or independently selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 2 and R 3 are linked together to form C 3-6 cycloalkyl or 3 to 6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 4 is selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 5 is selected from H, F, Cl, Br, I, OH, CN, NH 2, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; R 6 is selected from H, F, Cl, Br, I, OH, CN, NH 2, or selected from the group consisting of C 1-3 alkyl and C 1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 5 and R 6 are linked together to form C 3-6 cycloalkyl or 3 to 6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2 or 3 of R; L is selected from a single bond, -C(=O)O-, -C(=O)NH-; L 1 is selected from a single bond, -NH-; R 7 is selected from H, F, Cl, Br, I, OH, CN, NH 2, COOH, or selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 3 to 6 membered heterocycloalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; or, R 6 and R 7 are linked together to form C 3-6 cycloalkyl, C 3-6 heterocycloalkyl, phenyl and 5 to 6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 of R; R is selected from F, Cl, Br, I, OH, CN, NH 2, COOH, C(=O)NH 2, or selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl and 3 to 6 membered heteroalkyl, each of which is optionally substituted by 1, 2 or 3 of R'; the moiety is R' is selected from F, Cl, Br, I, OH, CN, NH 2, COOH, Me, Et, CF 3, CHF 2, CH 2 F, NHCH 3, N(CH 3) 2; "hetero" refers to a heteroatom or a heteroatomic group, which is selected from the group consisting of -C(=O)NH-, -NH-, -C(=NH)-, -S(=O) 2 NH-, -S(=O)NH-, -O-, -S-, =O, =S, -O-N=, -C(=O)O-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) 2 - and -NHC(=O)NH-; in any case above, the number of the heteroatom or the heteroatomic group is independently selected from 1, 2 or 3, respectively.