A method of predicting the responsiveness of a breast cancer patient to anthracycline treatment comprising a) determining the level of expression of at least four biomarkers, each having all or a measureable portion of the sequence of SEQ ID NOs: 1-4 respectively, in a sample from the cancer patient, and b) i) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a first reference patient known to be responsive to anthracycline treatment, or ii) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a second reference patient known to be non-responsive to anthracycline treatment, wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is similar to the level of expression of the biomarker in the sample from the first reference patient indicates that the cancer patient is responsive to said anthracycline treatment, or wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is dissimilar to the level of expression of the biomarker in the sample from the second reference patient indicates that the cancer patient is responsive to said anthracycline treatment. a) determining the level of expression of at least four biomarkers, each having all or a measureable portion of the sequence of SEQ ID NOs: 1-4 respectively, in a sample from the cancer patient, and b) i) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a first reference patient known to be responsive to anthracycline treatment, or ii) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a second reference patient known to be non-responsive to anthracycline treatment, wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is similar to the level of expression of the biomarker in the sample from the first reference patient indicates that the cancer patient is responsive to said anthracycline treatment, or wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is dissimilar to the level of expression of the biomarker in the sample from the second reference patient indicates that the cancer patient is responsive to said anthracycline treatment. i) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a first reference patient known to be responsive to anthracycline treatment, or ii) comparing the level of expression of the biomarker in the sample from the cancer patient to the level of expression of the biomarker in a sample from a second reference patient known to be non-responsive to anthracycline treatment, wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is similar to the level of expression of the biomarker in the sample from the first reference patient indicates that the cancer patient is responsive to said anthracycline treatment, or wherein a determination that the level of expression of the biomarker in the sample from the cancer patient is dissimilar to the level of expression of the biomarker in the sample from the second reference patient indicates that the cancer patient is responsive to said anthracycline treatment.