mhurhangee/ep-ind-claims huggingface dataset:
An ion source (100; 400; 700; 1400), comprising: a plasma generator (104; 404; 1404) configured for supplying plasma at an ionization region proximate to a sample surface (120; 1120; 1220; 1320; 1420), the plasma generator comprising a plasma generating component (132; 532; 632; 732; 932; 1132; 1232; 1332) configured for applying a radio frequency energy; and an interface (116; 716; 1416) configured for transferring analyte ions or photons produced in the plasma to an analytical instrument, characterized in that the plasma generating component is further configured for switching between operating in a desorption mode and in an ionization mode, wherein: in the desorption mode, the plasma generating component applies the radio frequency energy effective for heating the sample without generating plasma; and in the ionization mode, the plasma generating component applies the radio frequency energy effective for generating plasma from a plasma precursor gas. a plasma generator (104; 404; 1404) configured for supplying plasma at an ionization region proximate to a sample surface (120; 1120; 1220; 1320; 1420), the plasma generator comprising a plasma generating component (132; 532; 632; 732; 932; 1132; 1232; 1332) configured for applying a radio frequency energy; and an interface (116; 716; 1416) configured for transferring analyte ions or photons produced in the plasma to an analytical instrument, characterized in that the plasma generating component is further configured for switching between operating in a desorption mode and in an ionization mode, wherein: in the desorption mode, the plasma generating component applies the radio frequency energy effective for heating the sample without generating plasma; and in the ionization mode, the plasma generating component applies the radio frequency energy effective for generating plasma from a plasma precursor gas. in the desorption mode, the plasma generating component applies the radio frequency energy effective for heating the sample without generating plasma; and in the ionization mode, the plasma generating component applies the radio frequency energy effective for generating plasma from a plasma precursor gas.
A 5-substituted tetrandrine derivative of formula, wherein X is selected from oxygen, sulfur, nitrogen and carbonyloxy; n is 1 or 2, wherein n=1 when X is oxygen or sulfur, and n=2 when X is nitrogen; R is independently selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or cycloalkenyl, aryl or heteroaryl, aryl-C 1 -C 3 alkyl, heteroaryl-C 1 -C 3 alkyl, aryloxy-C 1 -C 3 alkyl and heteroaryloxy-C 1 -C 3 alkyl; when X is carbonyloxy, R can also be C 1 -C 6 alkoxy or C 1 -C 6 alkylthio; when X is nitrogen, the two R groups together with the nitrogen atom to which they are connected can form non-aromatic nitrogen-containing heterocyclyl or nitrogen-containing heteroaryl; the aforementioned radicals, except for H, are optionally substituted with a substituent selected from the group consisting of halogen, amino, C 1 -C 6 alkyl amino, nitro, cyano, hydroxyl, C 1 -C 6 alkoxy, thiol and C 1 -C 6 alkylthio; said cycloalkyl, cycloalkenyl, aryl, heteroaryl, nitrogen-containing heterocyclyl or nitrogen-containing heteroaryl are optionally substituted with a substituent selected from C 1 -C 6 alkyl, hydroxyl C 1 -C 6 alkyl, thiol C 1 -C 6 alkyl and phenyl; or a pharmaceutically acceptable salt thereof. X is selected from oxygen, sulfur, nitrogen and carbonyloxy; n is 1 or 2, wherein n=1 when X is oxygen or sulfur, and n=2 when X is nitrogen; R is independently selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or cycloalkenyl, aryl or heteroaryl, aryl-C 1 -C 3 alkyl, heteroaryl-C 1 -C 3 alkyl, aryloxy-C 1 -C 3 alkyl and heteroaryloxy-C 1 -C 3 alkyl; when X is carbonyloxy, R can also be C 1 -C 6 alkoxy or C 1 -C 6 alkylthio; when X is nitrogen, the two R groups together with the nitrogen atom to which they are connected can form non-aromatic nitrogen-containing heterocyclyl or nitrogen-containing heteroaryl; the aforementioned radicals, except for H, are optionally substituted with a substituent selected from the group consisting of halogen, amino, C 1 -C 6 alkyl amino, nitro, cyano, hydroxyl, C 1 -C 6 alkoxy, thiol and C 1 -C 6 alkylthio; said cycloalkyl, cycloalkenyl, aryl, heteroaryl, nitrogen-containing heterocyclyl or nitrogen-containing heteroaryl are optionally substituted with a substituent selected from C 1 -C 6 alkyl, hydroxyl C 1 -C 6 alkyl, thiol C 1 -C 6 alkyl and phenyl;
A pharmaceutical composition for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising a bispecific single chain antibody which has (a) a first binding domain specifically binding to human CD3, and (b) a second binding domain specifically binding to human CEA, wherein said second binding domain specific for human CEA comprises (i) a CDR-H1 having the amino acid sequence "SYWMH" (SEQ ID NO. 68), a CDR-H2 having the amino acid sequence "FIRNKANGGTTEYAASVKG" (SEQ ID NO. 67), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); (ii) a CDR-H1 having the amino acid sequence "SYWMH" (SEQ ID NO. 68), a CDR-H2 having the amino acid sequence "FILNKANGGTTEYAASVKG" (SEQ ID NO. 145), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); or (iii) a CDR-H1 having the amino acid sequence "TYAMH" (SEQ ID NO. 70), a CDR-H2 having the amino acid sequence "LISNDGSNKYYADSVKG" (SEQ ID NO. 69), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); and wherein said second binding domain comprises at least the amino acid sequence "DX 1 X 2 X 3 X 4 FYFDY" (SEQ ID NO. 65), wherein "X 1 ", "X 2 ", "X 3 " or "X 4 " represents any amino acid residue, and the amino acid residue "D" corresponds to Kabat position 95 of CDR-H3 of murine monoclonal antibody A5B7 and the amino acid residues "FYFDY" correspond to Kabat positions 100, 100a, 100b, 101, and 102, respectively, of CDR-H3 of murine monoclonal antibody A5B7. (a) a first binding domain specifically binding to human CD3, and (b) a second binding domain specifically binding to human CEA, (i) a CDR-H1 having the amino acid sequence "SYWMH" (SEQ ID NO. 68), a CDR-H2 having the amino acid sequence "FIRNKANGGTTEYAASVKG" (SEQ ID NO. 67), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); (ii) a CDR-H1 having the amino acid sequence "SYWMH" (SEQ ID NO. 68), a CDR-H2 having the amino acid sequence "FILNKANGGTTEYAASVKG" (SEQ ID NO. 145), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); or (iii) a CDR-H1 having the amino acid sequence "TYAMH" (SEQ ID NO. 70), a CDR-H2 having the amino acid sequence "LISNDGSNKYYADSVKG" (SEQ ID NO. 69), a CDR-L1 having the amino acid sequence "TLRRGINVGAYSIY" (SEQ ID NO. 73), a CDR-L2 having the amino acid sequence "YKSDSDKQQGS" (SEQ ID NO. 72) and a CDR-L3 having the amino acid sequence "MIWHSGASAV" (SEQ ID NO. 71); and
Commercial vehicle having two tandem axles (2, 3) which each comprise rocker arms mounted so as to be pivotable about a common transverse axis, wherein axle legs, which are connected together via a steering rod, of the two axles (4, 5) of the tandem axles (2, 3) are mounted on the rocker arms, characterised by a hydraulic linkage which connects the two axle legs of one of the two axles (4, 5) of the tandem axles (2, 3) together and engages the two axle legs via two adjusting cylinders, and by a steering drive which includes hydraulic steering cylinders (11, 12) which engage the axle legs of the two tandem axles (2, 3) and can be acted upon via a control device in a series connection, wherein the two tandem axles (2, 3) are connected together additionally via a hydraulic linkage having two control cylinders (20, 21), each one engaging one axle leg of one of the two axles (4, 5) of the tandem axles (2, 3).
A production line in which a plurality of the electronic component mounting machines are provided from an upstream toward a downstream in a transport direction of a substrate, each of the electronic component mounting machines comprising: an image-capturing device that is configured to capture images of a sub-fiducial mark (F1 to F3), being disposed on the substrate, and a main fiducial mark (f1 to f4) of which imaging position is determined with reference to the sub-fiducial mark (F1 to F3); and a control device that is configured to determine a mounting position of an electronic component (P1 to P6) with respect to the substrate with reference to the main fiducial mark (f1 to f4) when the main fiducial mark (f1 to f4) can be read from an image captured by the image-capturing device, while to determine the mounting position with reference to the sub-fiducial mark (F1 to F3), which is a reference source of the main fiducial mark (f1 to f4), when the main fiducial mark (f1 to f4) cannot be read from the image due to a print defect of the main fiducial mark (f1 to f4), wherein the control device of the electronic component mounting machine at an upstream end in the transport direction is configured to transmit information related to the main fiducial mark (f1 to f4), which cannot be read, to the electronic component mounting machine at the downstream in the transport direction when the main fiducial mark (f1 to f4) cannot be read from the image. an image-capturing device that is configured to capture images of a sub-fiducial mark (F1 to F3), being disposed on the substrate, and a main fiducial mark (f1 to f4) of which imaging position is determined with reference to the sub-fiducial mark (F1 to F3); and a control device that is configured to determine a mounting position of an electronic component (P1 to P6) with respect to the substrate with reference to the main fiducial mark (f1 to f4) when the main fiducial mark (f1 to f4) can be read from an image captured by the image-capturing device, while to determine the mounting position with reference to the sub-fiducial mark (F1 to F3), which is a reference source of the main fiducial mark (f1 to f4), when the main fiducial mark (f1 to f4) cannot be read from the image due to a print defect of the main fiducial mark (f1 to f4), wherein the control device of the electronic component mounting machine at an upstream end in the transport direction is configured to transmit information related to the main fiducial mark (f1 to f4), which cannot be read, to the electronic component mounting machine at the downstream in the transport direction when the main fiducial mark (f1 to f4) cannot be read from the image.
A method for steering traffic performed by a user equipment, UE, in a wireless communication system, the method comprising: transmitting, to a first access network, UE traffic steering preference information; receiving, from the first access network, traffic steering information which is set based on the UE traffic steering preference information; evaluating the traffic steering according to a first traffic steering rule and a second traffic steering rule based on the traffic steering information; and performing the traffic steering between the first access network and a second access network based on the result of the evaluation of the traffic steering, wherein the first traffic steering rule is prescribed by access network discovery and selection functions, ANDSF, and the second traffic steering rule is prescribed by the first access network, and wherein the UE traffic steering preference information indicates that the UE prefers the first traffic steering rule to the second traffic steering rule or prefers the second traffic steering rule to the first traffic steering rule. transmitting, to a first access network, UE traffic steering preference information; receiving, from the first access network, traffic steering information which is set based on the UE traffic steering preference information; evaluating the traffic steering according to a first traffic steering rule and a second traffic steering rule based on the traffic steering information; and performing the traffic steering between the first access network and a second access network based on the result of the evaluation of the traffic steering, wherein the first traffic steering rule is prescribed by access network discovery and selection functions, ANDSF, and the second traffic steering rule is prescribed by the first access network, and wherein the UE traffic steering preference information indicates that the UE prefers the first traffic steering rule to the second traffic steering rule or prefers the second traffic steering rule to the first traffic steering rule.
A motor comprising: a stator; a rotor axially aligned with the stator; a circuit board disposed at one end, in an axial direction, of the stator, and having a sensor for detecting a rotational angle of the rotor and a switching element for controlling a flow of current based on a detection result of the sensor; and a heat dissipating plate disposed at the one end, in the axial direction, of the stator, wherein the stator includes: an iron core including a cylinder and teeth protruding radially inward relative to the cylinder; an insulator covering the teeth and one end surface of the cylinder, in the axial direction; and a coil wound around the teeth covered by the insulator; and wherein the insulator includes an electrically insulating material having a lower rate of heat transfer than a material included in the iron core, the heat dissipating plate is attached to the insulator in a state in which the heat dissipating plate is in contact with the insulator without being in contact with the iron core, the circuit board is attached to the heat dissipating plate in a state in which the circuit board is in contact with the heat dissipating plate without being in contact with the iron core, in a view along the axial direction, the heat dissipating plate has a smaller outer diameter than the cylinder, and the heat dissipating plate is attached to the insulator in a location further radially inward than an outer circumferential surface of the cylinder. a stator; a rotor axially aligned with the stator; a circuit board disposed at one end, in an axial direction, of the stator, and having a sensor for detecting a rotational angle of the rotor and a switching element for controlling a flow of current based on a detection result of the sensor; and a heat dissipating plate disposed at the one end, in the axial direction, of the stator, wherein the stator includes: an iron core including a cylinder and teeth protruding radially inward relative to the cylinder; an insulator covering the teeth and one end surface of the cylinder, in the axial direction; and a coil wound around the teeth covered by the insulator; an iron core including a cylinder and teeth protruding radially inward relative to the cylinder; an insulator covering the teeth and one end surface of the cylinder, in the axial direction; and a coil wound around the teeth covered by the insulator; and wherein the insulator includes an electrically insulating material having a lower rate of heat transfer than a material included in the iron core, the heat dissipating plate is attached to the insulator in a state in which the heat dissipating plate is in contact with the insulator without being in contact with the iron core, the circuit board is attached to the heat dissipating plate in a state in which the circuit board is in contact with the heat dissipating plate without being in contact with the iron core, in a view along the axial direction, the heat dissipating plate has a smaller outer diameter than the cylinder, and the heat dissipating plate is attached to the insulator in a location further radially inward than an outer circumferential surface of the cylinder.
A method for performing temper rolling on a cold rolled steel sheet, the temper rolling including wet temper rolling, the cold rolled steel sheet being an annealed cold rolled steel sheet, the method characterized by comprising setting a tension T for the temper rolling based on a carbon content C of the cold rolled steel sheet, wherein the tension T is set based on a sheet thickness t of the cold rolled steel sheet, a load w per unit width, and a surface roughness Ra of a work roll, in addition to the carbon content C of the cold rolled steel sheet, and wherein the tension T is set based on formula below, t x w x (-200 x a - 90) / (a x (1 - logC)) + 17.1 ≤ T ≤ t x w x (-200 x a + 10) / (a x (1 - logC)) + 17.1 where t is the sheet thickness in mm of the steel sheet, w is the load in tonf/mm per unit width, a is the surface roughness Ra in μm of the work roll, C is the carbon content in mass% of the steel sheet, and T is the tension in kgf/mm 2 per unit cross-sectional area. wherein the tension T is set based on a sheet thickness t of the cold rolled steel sheet, a load w per unit width, and a surface roughness Ra of a work roll, in addition to the carbon content C of the cold rolled steel sheet, and wherein the tension T is set based on formula below, t x w x (-200 x a - 90) / (a x (1 - logC)) + 17.1 ≤ T ≤ t x w x (-200 x a + 10) / (a x (1 - logC)) + 17.1 where t is the sheet thickness in mm of the steel sheet, w is the load in tonf/mm per unit width, a is the surface roughness Ra in μm of the work roll, C is the carbon content in mass% of the steel sheet, and T is the tension in kgf/mm 2 per unit cross-sectional area.
A travel working machine comprising: an automatic travel control unit configured to implement automatic travel based on automatic travel information necessary for automatic travel; a manual travel control unit configured to implement manual travel based on an operation signal from a manual travel operating unit; a machine body status detecting unit configured to output machine body status information indicating a machine body status based on the operation signal and a detection signal received from a status detecting device; and an automatic travel management section configured to determine forbiddance of automatic travel by the automatic travel control unit and permission of the automatic travel; characterized in that the automatic travel management section is configured to determine forbiddance of automatic travel by the automatic travel control unit and permission of the automatic travel based on the machine body status information, and in that the travel management section is configured to also output a control command in automatic travel forbiddance, for deciding control of the machine body after a command to forbid the automatic travel has been issued, wherein content of the control command is selected from a plurality of options, based on the machine body status information on whose basis the forbiddance of automatic travel has been determined by the automatic travel management section. an automatic travel control unit configured to implement automatic travel based on automatic travel information necessary for automatic travel; a manual travel control unit configured to implement manual travel based on an operation signal from a manual travel operating unit; a machine body status detecting unit configured to output machine body status information indicating a machine body status based on the operation signal and a detection signal received from a status detecting device; and an automatic travel management section configured to determine forbiddance of automatic travel by the automatic travel control unit and permission of the automatic travel;
A heating device, comprising: a cylindrical belt having an axial direction; a heater disposed on an inner surface of the cylindrical belt and having a longitudinal direction parallel to the axial direction; a press roller configured to contact an outer surface of the cylindrical belt at a position opposite the heater and form a nip, the press roller being configured to rotate to convey a sheet through the nip, and have a concave shape in which both longitudinal end portions of the press roller project further by a first projection amount in a radial direction of the press roller than a central portion of the press roller between the longitudinal end portions in the longitudinal direction; and a holder having a first surface supporting the heater and facing the cylindrical belt, the holder having a second surface that is opposite the first surface and has a center portion between the longitudinal end portions of the second surface, the center portion projecting in a direction orthogonal to the first surface by a second projection amount that is greater than the first projection amount wherein a first thickness along a direction perpendicular to the longitudinal direction of the holder in the central portion is greater than a second thickness in the longitudinal end portions, the second projection amount corresponding to the difference between the first thickness and the second thickness. a cylindrical belt having an axial direction; a heater disposed on an inner surface of the cylindrical belt and having a longitudinal direction parallel to the axial direction; a press roller configured to contact an outer surface of the cylindrical belt at a position opposite the heater and form a nip, the press roller being configured to rotate to convey a sheet through the nip, and have a concave shape in which both longitudinal end portions of the press roller project further by a first projection amount in a radial direction of the press roller than a central portion of the press roller between the longitudinal end portions in the longitudinal direction; and a holder having a first surface supporting the heater and facing the cylindrical belt, the holder having a second surface that is opposite the first surface and has a center portion between the longitudinal end portions of the second surface, the center portion projecting in a direction orthogonal to the first surface by a second projection amount that is greater than the first projection amount wherein a first thickness along a direction perpendicular to the longitudinal direction of the holder in the central portion is greater than a second thickness in the longitudinal end portions, the second projection amount corresponding to the difference between the first thickness and the second thickness.