A method, performed by a first radio network node in a radio communication network where subframes are transmitted in pre-determined positions within radio frames, wherein the first radio network node employs a subframe scheme where at least one of the pre-determined positions is allocated to a flexible subframe in which the direction of signal transmission is variable between uplink and downlink from one radio frame to another, for triggering mitigation of interference on downlink radio signals received by a victim User Equipment, UE, in a victim cell, said interference being caused by transmission of uplink radio signals from an aggressor UE in an aggressor cell during the flexible subframe, the method comprising: - detecting that a first UE, being one of the victim and aggressor UEs, is served by the first radio network node, - identifying a second radio network node which employs a subframe scheme such that an uplink transmission from the aggressor UE potentially overlaps at least partly with downlink reception at the victim UE during the flexible subframe, wherein the subframe scheme employed by the second radio network node comprises a flexible subframe that overlaps at least partly in time with the flexible subframe of the first radio network node, and - sending a notification to the identified second radio network node, the notification indicating the flexible subframe and the first UE being served by the first radio network node, to trigger the second radio network node to execute an interference mitigation action for alleviating said interference when a second UE, being the other one of the victim and aggressor UEs, is served by the second radio network node during the flexible subframe, wherein the notification is sent after determining (702, 704) that a level of said interference during the flexible subframe is higher than a threshold based on measurements of signals communicated to or from the first UE and/or wherein the first UE is detected when it is located in a cell border region of the first radio network node adjacent to a cell of the second radio network node and optionally wherein the cell border region is determined based on measurements of path loss between UEs served by the first radio network node and the first radio network node. - detecting that a first UE, being one of the victim and aggressor UEs, is served by the first radio network node, - identifying a second radio network node which employs a subframe scheme such that an uplink transmission from the aggressor UE potentially overlaps at least partly with downlink reception at the victim UE during the flexible subframe, wherein the subframe scheme employed by the second radio network node comprises a flexible subframe that overlaps at least partly in time with the flexible subframe of the first radio network node, and - sending a notification to the identified second radio network node, the notification indicating the flexible subframe and the first UE being served by the first radio network node, to trigger the second radio network node to execute an interference mitigation action for alleviating said interference when a second UE, being the other one of the victim and aggressor UEs, is served by the second radio network node during the flexible subframe, wherein the notification is sent after determining (702, 704) that a level of said interference during the flexible subframe is higher than a threshold based on measurements of signals communicated to or from the first UE and/or wherein the first UE is detected when it is located in a cell border region of the first radio network node adjacent to a cell of the second radio network node and optionally wherein the cell border region is determined based on measurements of path loss between UEs served by the first radio network node and the first radio network node.