A frequency-domain optical coherence tomography, FD-OCT system with integrated pressure measurement comprising: an interferometer comprising: a wavelength swept laser; a source arm in optical communication with the wavelength swept laser; a reference arm in optical communication with a reference reflector and in optical communication with the source arm; a probe interface; a sample arm in optical communication with a first optical connector of the probe interface and in optical communication with the source arm; a first photodetector having a signal output; and a detector arm in optical communication with the first photodetector and in optical communication with the sample arm; an acquisition and display system comprising: an analog to digital converter having a signal input in electrical communication with the first photodetector signal output and the signal output; a processor system in electrical communication with the analog to digital converter signal output; and a display in electrical communication with the processor system; and a probe comprising: an optical fiber, an optical Fabry-Perot pressure transducer mounted at the distal end of said optical fiber and a beam splitter; wherein the beam splitter reflects a first fraction of the incident light from the optical fiber at specific wavelengths for FD-OCT measurements and transmits the remaining fraction of the incident light to the optical Fabry-Perot pressure transducer for pressure measurements, wherein the probe is configured for optical connection to the first optical connector of the probe interface. an interferometer comprising: a wavelength swept laser; a source arm in optical communication with the wavelength swept laser; a reference arm in optical communication with a reference reflector and in optical communication with the source arm; a wavelength swept laser; a source arm in optical communication with the wavelength swept laser; a reference arm in optical communication with a reference reflector and in optical communication with the source arm; a probe interface; a sample arm in optical communication with a first optical connector of the probe interface and in optical communication with the source arm; a first photodetector having a signal output; and a detector arm in optical communication with the first photodetector and in optical communication with the sample arm; a sample arm in optical communication with a first optical connector of the probe interface and in optical communication with the source arm; a first photodetector having a signal output; and a detector arm in optical communication with the first photodetector and in optical communication with the sample arm; an acquisition and display system comprising: an analog to digital converter having a signal input in electrical communication with the first photodetector signal output and the signal output; a processor system in electrical communication with the analog to digital converter signal output; and a display in electrical communication with the processor system; and an analog to digital converter having a signal input in electrical communication with the first photodetector signal output and the signal output; a processor system in electrical communication with the analog to digital converter signal output; and a display in electrical communication with the processor system; and a probe comprising: an optical fiber, an optical Fabry-Perot pressure transducer mounted at the distal end of said optical fiber and a beam splitter; wherein the beam splitter reflects a first fraction of the incident light from the optical fiber at specific wavelengths for FD-OCT measurements and transmits the remaining fraction of the incident light to the optical Fabry-Perot pressure transducer for pressure measurements, wherein the probe is configured for optical connection to the first optical connector of the probe interface. an optical fiber, an optical Fabry-Perot pressure transducer mounted at the distal end of said optical fiber and a beam splitter; wherein the beam splitter reflects a first fraction of the incident light from the optical fiber at specific wavelengths for FD-OCT measurements and transmits the remaining fraction of the incident light to the optical Fabry-Perot pressure transducer for pressure measurements, wherein the probe is configured for optical connection to the first optical connector of the probe interface.