mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for producing a stem cell clone, which comprises the steps of: (i) introducing, into stem cells capable of being induced to differentiate into megakaryocyte progenitor cells, an exogenous gene associated with induction of differentiation into megakaryocyte progenitor cells; (ii) inducing differentiation of the stem cells, introduced with the exogenous gene, into the megakaryocyte progenitor cells; (iii) dedifferentiating the differentiation-induced megakaryocyte progenitor cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii); wherein the exogenous gene associated with induction of differentiation is at least one exogenous gene selected from the group consisting of oncogenes including MYC family genes, genes (polycomb genes) inhibiting expression of a p16 gene or a p19 gene including Bmi1, and apoptosis suppressing genes including BCL-XL gene; wherein the dedifferentiation in step (iii) is carried out by introducing a reprogramming factor selected from the group consisting of OCT3/4, SOX2 and KLF4 into the differentiation-induced megakaryocyte progenitor cells. (i) introducing, into stem cells capable of being induced to differentiate into megakaryocyte progenitor cells, an exogenous gene associated with induction of differentiation into megakaryocyte progenitor cells; (ii) inducing differentiation of the stem cells, introduced with the exogenous gene, into the megakaryocyte progenitor cells; (iii) dedifferentiating the differentiation-induced megakaryocyte progenitor cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii);
Charging device, in particular an exhaust gas turbocharging device for a motor vehicle comprising: - a shaft supporting a compressor wheel, - a fixing device for fixing the compressor wheel on the shaft, - at least one component (5, 6, 7) fixed on the shaft and fixed by the fixing device together with the compressor wheel, wherein at least in a predefined temperature range an expansion coefficient (α 3) of the at least one component (5, 6, 7) is smaller than an expansion coefficient (α 1) of the compressor wheel, characterised in that - the expansion coefficient (α 3) of the at least one component (5, 6, 7) is virtually zero or negative, - at least one fixing element of the fixing device has an expansion coefficient (α f) which is smaller than the expansion coefficient (α 1) of the compressor wheel, - at least one such fixing element has an expansion coefficient (α f) which is smaller than the expansion coefficient (α 2) of the shaft section. - a shaft supporting a compressor wheel, - a fixing device for fixing the compressor wheel on the shaft, - at least one component (5, 6, 7) fixed on the shaft and fixed by the fixing device together with the compressor wheel, - the expansion coefficient (α 3) of the at least one component (5, 6, 7) is virtually zero or negative, - at least one fixing element of the fixing device has an expansion coefficient (α f) which is smaller than the expansion coefficient (α 1) of the compressor wheel, - at least one such fixing element has an expansion coefficient (α f) which is smaller than the expansion coefficient (α 2) of the shaft section.
A method for qualitatively evaluating a digital audio signal, which calculates in real time and in continuous time in successive time windows, a quality indicator obtained from said digital audio signal, characterized in that said quality indicator consists of a vector associated with each time window, said vector having a dimension at least one hundred times less than the number of audio samples in a time window, said dimension ranging from 1 to 10, preferably from 1 to 5, and more particularly from 2 to 5, and in that the generation of said quality indicator vector implements, at least for the audio signal to evaluate, the following steps: a) calculating a temporal activity of the signal in each time window, b) calculating a sliding average over N 1 successive values of the temporal activity; c) retaining the minimum value from M 1 successive values of the sliding average. a) calculating a temporal activity of the signal in each time window, b) calculating a sliding average over N 1 successive values of the temporal activity; c) retaining the minimum value from M 1 successive values of the sliding average.
Apparatus for shaping at least one bar of an alternator comprising: - at least one shaping assembly configured to shape at least one portion of the bar; - a moving assembly configured to move at least the shaping assembly with respect to the bar; wherein the moving assembly is configured to move at least the shaping assembly along three different directions which are orthogonal one to the other; the apparatus being characterized in that the moving assembly comprises at least one moving unit (10, 11) provided with a carriage, coupled to the shaping assembly, a first guide configured to guide the movement of the carriage, a second guide configured to guide the movement of the first guide, and a third guide, configured to guide the movement of the second guide. - at least one shaping assembly configured to shape at least one portion of the bar; - a moving assembly configured to move at least the shaping assembly with respect to the bar; wherein the moving assembly is configured to move at least the shaping assembly along three different directions which are orthogonal one to the other;
A method of imaging living tissue, the method comprising a) introducing a photoacoustic contrast agent consisting of a photosensitizer into living tissue, wherein the photosensitizer consists of a second generation porphyrin-based photosensitizer selected from the group consisting of protoporphyrin, chlorin, phthalocyanine, and combinations thereof, a non-porphyrin-based photosensitizer selected from the group consisting of squarine, methylene blue, and combinations thereof, and combinations thereof; and b) obtaining an image of the living tissue by multispectral optoacoustic tomographic imaging at a wavelength in the range of about 680 nm to about 900 nm. a) introducing a photoacoustic contrast agent consisting of a photosensitizer into living tissue, wherein the photosensitizer consists of a second generation porphyrin-based photosensitizer selected from the group consisting of protoporphyrin, chlorin, phthalocyanine, and combinations thereof, a non-porphyrin-based photosensitizer selected from the group consisting of squarine, methylene blue, and combinations thereof, and combinations thereof; and b) obtaining an image of the living tissue by multispectral optoacoustic tomographic imaging at a wavelength in the range of about 680 nm to about 900 nm.
Method for mass spectrometric examination of a gas mixture, comprising the following method steps: parallel or serial ionization of the gas mixture to be examined by activating of at least two ionization devices (9a, 9b, 9c) operating using different ionization procedures, and detecting of the ionized gas mixture in a detector for the mass spectrometric examination thereof, wherein one of the at least two ionization devices (9a, 9b, 9c) is embodied as a plasma ionization device which is external to the detector, characterized in that the gas mixture is additionally ionized directly in the detector by charge exchange ionization. parallel or serial ionization of the gas mixture to be examined by activating of at least two ionization devices (9a, 9b, 9c) operating using different ionization procedures, and detecting of the ionized gas mixture in a detector for the mass spectrometric examination thereof, wherein one of the at least two ionization devices (9a, 9b, 9c) is embodied as a plasma ionization device which is external to the detector, characterized in that the gas mixture is additionally ionized directly in the detector by charge exchange ionization.
A bearing comprising: a base ring, an inner wall of which extends in an axial direction to form a shielding ring; an upper rotating frame, which is annular and sleeved on the shielding ring; a lower rotating frame, which is annular, sleeved on the shielding ring, and arranged below the upper rotating frame; a moving assembly, which is arranged between the upper rotating frame and the lower rotating frame; and a supporting frame; wherein, the supporting frame is annular; and an inner wall of the supporting frame extends in an axial direction to form a shielding edge; the base ring is sleeved on the shielding edge; characterized in that the supporting frame is provided with a first annular groove, and the first annular groove is provided with a first drainage hole. a base ring, an inner wall of which extends in an axial direction to form a shielding ring; an upper rotating frame, which is annular and sleeved on the shielding ring; a lower rotating frame, which is annular, sleeved on the shielding ring, and arranged below the upper rotating frame; a moving assembly, which is arranged between the upper rotating frame and the lower rotating frame; and a supporting frame; wherein, the supporting frame is annular; and an inner wall of the supporting frame extends in an axial direction to form a shielding edge; the base ring is sleeved on the shielding edge; characterized in that the supporting frame is provided with a first annular groove, and the first annular groove is provided with a first drainage hole.
A garment comprising: a front panel having a top edge; an opposing back panel having a top edge and being connected with the front panel along a lateral edge so as to form a cavity in which an upper body of a subject is received when the garment is worn; a pair of opposing hollow sleeves, each of the sleeves being connected to at least one of the front or back panel (12; 14) and in communication with the cavity so as to receive an arm of the subject when the garment is worn; a collar configured to surround a neck of the subject when the garment is worn; characterized in that said garment is for use in clinical inspection and further comprises: a pair of shoulder straps, each of the straps being connected at one end to the collar and at an opposing end to at least one of the front panel, the back panel, or one of the sleeves; a first opening formed by at least the shoulder straps, the top edge of the front panel, and the collar, and configured to expose a top portion of a chest of the subject when the garment is worn; and a second opening formed by at least the shoulder straps, the top edge of the back panel, and the collar, and configured to expose a top portion of a back of the subject when the garment is worn. a front panel having a top edge; an opposing back panel having a top edge and being connected with the front panel along a lateral edge so as to form a cavity in which an upper body of a subject is received when the garment is worn; a pair of opposing hollow sleeves, each of the sleeves being connected to at least one of the front or back panel (12; 14) and in communication with the cavity so as to receive an arm of the subject when the garment is worn; a collar configured to surround a neck of the subject when the garment is worn; characterized in that said garment is for use in clinical inspection and further comprises: a pair of shoulder straps, each of the straps being connected at one end to the collar and at an opposing end to at least one of the front panel, the back panel, or one of the sleeves; a first opening formed by at least the shoulder straps, the top edge of the front panel, and the collar, and configured to expose a top portion of a chest of the subject when the garment is worn; and a second opening formed by at least the shoulder straps, the top edge of the back panel, and the collar, and configured to expose a top portion of a back of the subject when the garment is worn. a pair of shoulder straps, each of the straps being connected at one end to the collar and at an opposing end to at least one of the front panel, the back panel, or one of the sleeves; a first opening formed by at least the shoulder straps, the top edge of the front panel, and the collar, and configured to expose a top portion of a chest of the subject when the garment is worn; and a second opening formed by at least the shoulder straps, the top edge of the back panel, and the collar, and configured to expose a top portion of a back of the subject when the garment is worn.
Method of distributing and retrieving data on a computer network (2, 4) with peer nodes (5, 15), comprising: (a)encrypting, with a secret key, a file containing said data; (b)splitting the encrypted file into blocks (25, 50) and splitting the secret key into secret shares (33, 59); (c) distributing the blocks and the secret shares to the peer nodes (5, 15); (d)upon request of a client to access the file, retrieving via one of the peer nodes (5, 15) the encrypted blocks (50, 98) for reconstructing the encrypted file, retrieving at least some of the secret shares (59, 90) for reconstructing the secret key (22, 97), and decrypting the encrypted file (23, 99) with the reconstructed secret key; characterized in that the peer nodes (5, 15) share a blockchain (10, 70) so as to form a blockchain network; at step (c), the secret shares (33, 59) are transmitted to the peer nodes (5, 15) via messages sent over the blockchain network; and at step (d), requesting and retrieving the secret shares (59, 90) is done via messages (81, 82) sent over the blockchain network. (a)encrypting, with a secret key, a file containing said data; (b)splitting the encrypted file into blocks (25, 50) and splitting the secret key into secret shares (33, 59); (c) distributing the blocks and the secret shares to the peer nodes (5, 15); (d)upon request of a client to access the file, retrieving via one of the peer nodes (5, 15) the encrypted blocks (50, 98) for reconstructing the encrypted file, retrieving at least some of the secret shares (59, 90) for reconstructing the secret key (22, 97), and decrypting the encrypted file (23, 99) with the reconstructed secret key; characterized in that the peer nodes (5, 15) share a blockchain (10, 70) so as to form a blockchain network; at step (c), the secret shares (33, 59) are transmitted to the peer nodes (5, 15) via messages sent over the blockchain network; and at step (d), requesting and retrieving the secret shares (59, 90) is done via messages (81, 82) sent over the blockchain network.
Attachment device for injection needles, for pushing onto a thread of an injection apparatus, wherein the attachment device is formed as a cap with one open and one closed end, centrally and vertically holding a needle, the circumference sleeve surface of which is slightly elastic and comprises at least three cams facing in the direction of the thread, which engage the thread channels when the cap is pushed onto the thread, characterised in that the at least three cams form at least six contact points on at least two levels with the thread.
A method of risk stratification comprising: determining a normalized gene expression profile for a single marker gene consisting of phosphodiesterase 4D variant 7 (PDE4D7), with respect to a set of reference gene(s) selected from the group consisting of: Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), Tubulin-Alpha-lb (TUBA1B), Homo sapiens pumilio RNA-Binding Family Member and Homo sapiens TATA box binding protein, and combinations thereof; determining a prognostic risk score with a scoring function, based on the normalized gene expression profile, the scoring function having been derived from gene expression profiles for biological samples taken from subjects that have been monitored for prostate cancer; and determining a combined prognostic risk score based on the prognostic risk score and a second risk determination being a National Comprehensive Cancer Network (NCCN) classification. determining a normalized gene expression profile for a single marker gene consisting of phosphodiesterase 4D variant 7 (PDE4D7), with respect to a set of reference gene(s) selected from the group consisting of: Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), Tubulin-Alpha-lb (TUBA1B), Homo sapiens pumilio RNA-Binding Family Member and Homo sapiens TATA box binding protein, and combinations thereof; determining a prognostic risk score with a scoring function, based on the normalized gene expression profile, the scoring function having been derived from gene expression profiles for biological samples taken from subjects that have been monitored for prostate cancer; and determining a combined prognostic risk score based on the prognostic risk score and a second risk determination being a National Comprehensive Cancer Network (NCCN) classification.
A radial foil bearing that, by being fitted on a rotating shaft, supports the rotating shaft, comprising: a cylindrical top foil that is arranged facing the rotating shaft; a back foil that is arranged on the outer side of the top foil in the radial direction; and a cylindrical bearing housing that houses the top foil and the back foil in the state of being inserted therein, wherein, an engagement notch that extends from the inner circumferential edge to the outer circumferential edge of the bearing housing is formed at both sides of the bearing housing in the axial direction of the radial foil bearing, and an engagement protruding piece that engages with each engagement notche provided at both side end portions of the back foil in the axial direction of the radial foil bearing, on one side in the circumferential direction of the bearing housing; characterised in that an engagement groove with a depth that is shallower than the engagement notch is formed in the inner circumferential surface of the bearing housing, between the opposing pair of engagement notches; an engagement protrusion with a height that is lower than the engagement protruding piece is formed on the back foil between the engagement protruding pieces; and along with the engagement protruding piece engaging in the engagement notch, the engagement protrusion engages in the engagement groove. a cylindrical top foil that is arranged facing the rotating shaft; a back foil that is arranged on the outer side of the top foil in the radial direction; and a cylindrical bearing housing that houses the top foil and the back foil in the state of being inserted therein, wherein, an engagement notch that extends from the inner circumferential edge to the outer circumferential edge of the bearing housing is formed at both sides of the bearing housing in the axial direction of the radial foil bearing, and an engagement protruding piece that engages with each engagement notche provided at both side end portions of the back foil in the axial direction of the radial foil bearing, on one side in the circumferential direction of the bearing housing; characterised in that an engagement groove with a depth that is shallower than the engagement notch is formed in the inner circumferential surface of the bearing housing, between the opposing pair of engagement notches; an engagement protrusion with a height that is lower than the engagement protruding piece is formed on the back foil between the engagement protruding pieces; and along with the engagement protruding piece engaging in the engagement notch, the engagement protrusion engages in the engagement groove.
Hydraulic actuator, comprising a hydraulic drive cylinder configured with a bellows, a hydraulic output cylinder, which is hydraulically coupled to the drive cylinder, a drive actuator, which is motion-coupled to the drive cylinder, characterized in that the hydraulic actuator further comprises a pressure limitation valve, which depending on an acting time of a force exerted by the drive actuator upon the drive cylinder pressure-limits the output cylinder, by a preload volume being adjustable depending on the acting time of the force and by the pressure limitation valve being controllable by means of the preload volume.
An actuator control arrangement comprising a pair of rotary control valves (10a, 10b) used in combination in controlling the operation of an actuator; first means to ensure that the control valves (10a, 10b) are driven synchronously and, second means such that in the event of a jam within one of the valves (10a, 10b), the jammed control valve (10a, 10b) occupies its by-pass position at any time that the still functioning valve (10a, 10b) establishes communication between a control line(s) (50, 52) and a pressure line and/or a return line; and wherein each rotary control valve comprises a first spool, a second spool encircling at least part of the first spool and angularly moveable relative thereto, and a sleeve encircling at least part of the second spool, the second spool being angularly moveable relative to the sleeve, the first and second spools (22, 24) having first and second series of ports (28, 30) registrable with one another, depending upon the relative angular positions of the first and second spools (22, 24), to control communication between at least the pressure line, the return line and the control line (50, 52) provided in or connected to the sleeve, the second spool and the sleeve having third and fourth series of ports (66, 68), axially spaced from the first and second series of ports (28, 30) and registrable with one another, depending upon the relative angular positions of the second spool and the sleeve, to control communication between at least the control line (50, 52) and the return line, and latch means operable to resist movement of the second spool relative to the sleeve.
An oil leakage sensor for motors, especially for robot servomotors comprising: sensing part in a form of a capacitor mountable at a motor drainage hole in such a way that in case of oil leakage a chamber between electrodes of the capacitor Is penetrated by the leaking oil, and an electronic circuit for measuring capacitance of said capacitor, characterized in that the chamber is divided into a measuring chamber and a reference chamber, being separate chambers, whereby leaking oil and humidity may penetrate the measuring chamber, while the reference chamber may be penetrated by the humidity only. sensing part in a form of a capacitor mountable at a motor drainage hole in such a way that in case of oil leakage a chamber between electrodes of the capacitor Is penetrated by the leaking oil, and an electronic circuit for measuring capacitance of said capacitor, characterized in that the chamber is divided into a measuring chamber and a reference chamber, being separate chambers, whereby leaking oil and humidity may penetrate the measuring chamber, while the reference chamber may be penetrated by the humidity only.
A method of connecting a first threaded tubular to a second threaded tubular supported by a spider on a drilling rig, comprising: engaging the first threaded tubular with the second threaded tubular; making up the connection by rotating the first tubular using a top drive; and controlling unwinding of the first tubular after the connection is made up. engaging the first threaded tubular with the second threaded tubular; making up the connection by rotating the first tubular using a top drive; and controlling unwinding of the first tubular after the connection is made up.