A compound of Formula 1, or a pharmaceutically acceptable salt thereof, wherein: G is N; L 1 and L 2 are each independently selected from -NH- and a bond; R 1 and R 2 are each independently selected from hydrogen, halo, C 1-3 alkyl, and C 1-3 haloalkyl, or R 1 and R 2, together with the atom to which they are attached, form a C 3-6 cycloalkyl; R 3 is selected from: (a) C 2-6 alkyl, C 2-5 heterocyclyl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, R 6, and R 7; and (b) 2-amino-cyclohex-1 -yl, which is unsubstituted; R 4 is selected from C 6-14 aryl and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -CN, R 6, and R 7; each R 6 is independently selected from -OR 8, -N(R 8)R 9, -NR 8 C R 9, -C R 8, -C OR 8, -C N(R 8)R 9, -C N(R 8)OR 9, -C N(R 8)S 2 R 9, -N(R 8)S 2 R 9, -S n R 8, and -S 2 N(R 8)R 9; each R 7 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 8 and R 9 is independently selected from hydrogen or from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 10 is independently selected from -OR 11, -N(R 11)R 12, -N(R 11)C R 12, -C R 11, -C OR 11, -C N(R 11)R 12, -C N(R 11)OR 12, -C N(R 11)S 2 R 12, -NR 11 S 2 R 12, -S n R 11, and -S 2 N(R 11)R 12; each R 11 and R 12 is independently selected from hydrogen and C 1-6 alkyl; each n is independently selected from 0, 1 and 2; and each m is independently selected from 0, 1, 2, 3, and 4; wherein each of the aforementioned heteroaryl moieties has one to four heteroatoms independently selected from N, O, and S, and each of the aforementioned heterocyclyl moieties is saturated or partially unsaturated and has one or two heteroatoms independently selected from N, O, and S. G is N; L 1 and L 2 are each independently selected from -NH- and a bond; R 1 and R 2 are each independently selected from hydrogen, halo, C 1-3 alkyl, and C 1-3 haloalkyl, or R 1 and R 2, together with the atom to which they are attached, form a C 3-6 cycloalkyl; R 3 is selected from: (a) C 2-6 alkyl, C 2-5 heterocyclyl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, R 6, and R 7; and (b) 2-amino-cyclohex-1 -yl, which is unsubstituted; (a) C 2-6 alkyl, C 2-5 heterocyclyl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, R 6, and R 7; and (b) 2-amino-cyclohex-1 -yl, which is unsubstituted; R 4 is selected from C 6-14 aryl and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -CN, R 6, and R 7; each R 6 is independently selected from -OR 8, -N(R 8)R 9, -NR 8 C R 9, -C R 8, -C OR 8, -C N(R 8)R 9, -C N(R 8)OR 9, -C N(R 8)S 2 R 9, -N(R 8)S 2 R 9, -S n R 8, and -S 2 N(R 8)R 9; each R 7 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 8 and R 9 is independently selected from hydrogen or from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 10 is independently selected from -OR 11, -N(R 11)R 12, -N(R 11)C R 12, -C R 11, -C OR 11, -C N(R 11)R 12, -C N(R 11)OR 12, -C N(R 11)S 2 R 12, -NR 11 S 2 R 12, -S n R 11, and -S 2 N(R 11)R 12; each R 11 and R 12 is independently selected from hydrogen and C 1-6 alkyl; each n is independently selected from 0, 1 and 2; and each m is independently selected from 0, 1, 2, 3, and 4; wherein each of the aforementioned heteroaryl moieties has one to four heteroatoms independently selected from N, O, and S, and each of the aforementioned heterocyclyl moieties is saturated or partially unsaturated and has one or two heteroatoms independently selected from N, O, and S.