Discharger, in particular expendable syringe, for discharging a predetermined amount of fluid, in particular a liquid including at least one medical, dental or veterinary agent, the discharger comprising - a housing defining a longitudinal axis and having a proximal end and a distal end, - a discharge device arranged at least partly inside the housing and having an inlet opening situated inside the housing and an outlet opening, the discharge device further defining a discharge passage for the fluid extending between the inlet opening and the outlet opening, - a carriage received in a proximal end region of the housing and being moveable relative to the housing along the longitudinal axis between a starting position and a final discharge position, wherein in the starting position the carriage protrudes from the proximal end of the housing so as to be pushable by a user further into the housing and towards the final discharge position, and wherein the carriage defines a receiving space which is adapted to be loaded with a separate container holding an amount of fluid to be discharged, and - activation means for establishing a flow connection for the fluid from within the receiving space of the carriage to the inlet opening of the discharge device, the activation means being inoperative when the carriage is in the starting position and being adapted to establish the flow connection when the carriage is in the final discharge position or is being moved towards the final discharge position, wherein after establishment of the flow connection the carriage is pushable further into the housing, such that a proximal end portion of the discharge device enters into the fluid space of the container, thereby urging the fluid out of the container. - a housing defining a longitudinal axis and having a proximal end and a distal end, - a discharge device arranged at least partly inside the housing and having an inlet opening situated inside the housing and an outlet opening, the discharge device further defining a discharge passage for the fluid extending between the inlet opening and the outlet opening, - a carriage received in a proximal end region of the housing and being moveable relative to the housing along the longitudinal axis between a starting position and a final discharge position, wherein in the starting position the carriage protrudes from the proximal end of the housing so as to be pushable by a user further into the housing and towards the final discharge position, and wherein the carriage defines a receiving space which is adapted to be loaded with a separate container holding an amount of fluid to be discharged, and - activation means for establishing a flow connection for the fluid from within the receiving space of the carriage to the inlet opening of the discharge device, the activation means being inoperative when the carriage is in the starting position and being adapted to establish the flow connection when the carriage is in the final discharge position or is being moved towards the final discharge position, wherein after establishment of the flow connection the carriage is pushable further into the housing, such that a proximal end portion of the discharge device enters into the fluid space of the container, thereby urging the fluid out of the container.