A system (100, 200, 300) for treating tissue, comprising: an applicator (104, 204, 304) including a catheter (106, 206, 306) and a control member (108, 208, 308) extending therethrough, the catheter (106, 206, 306) extending longitudinally from a proximal end to a distal end and including a lumen (132, 332) extending therethrough, the control member (108, 208, 308) longitudinally movable relative to the catheter (106, 206, 306) and including an abutment structure (120, 220, 320) proximate a distal end thereof; and a clip assembly (102, 202, 302) releasably coupleable to a distal end of the applicator (104, 204, 304), the clip assembly (102, 202, 302) including a pair of clip arms (110, 210, 310), each of the clip arms extending from a proximal end (136, 236) to a distal end, the proximal end (136, 236) of each of the clip arms (110, 210, 310) slidably received within a channel of a capsule (112, 212, 312) and configured to be releasably coupled to the distal end of the control member (108, 208, 308) so that the clip arms (110, 210, 310) are movable relative to the capsule (112, 212, 312) between a tissue receiving configuration, in which distal ends of the clip arms (110, 210, 310) are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another, the capsule (112, 212, 312) including proximal tabs (114, 214, 314) movable between a biased non-engaging configuration, in which the proximal tabs (114, 214, 314) extend into the channel, and an engaging configuration, in which the proximal tabs (114, 214, 314) extend laterally outward relative to a longitudinal axis of the capsule (112, 212, 312) to engage an engaging portion (218, 318) of the catheter (106, 206, 306), wherein the abutment structure (120, 220, 320) maintains an engagement with the proximal tabs (114, 214, 314), holding the proximal tabs (114, 214, 314) in the engaging configuration, while the abutment structure (120, 220, 320) is received within the capsule (112, 212, 312) characterised in that the clip arms (110, 210, 310) include a locking tab extending laterally outward therefrom and being configured to engage a portion of the capsule when the clip arms (110, 210, 310) have been drawn into the capsule by a predetermined distance, the locking tab being configured to lock the clip arms (110, 210, 310) in the tissue clipping configuration. an applicator (104, 204, 304) including a catheter (106, 206, 306) and a control member (108, 208, 308) extending therethrough, the catheter (106, 206, 306) extending longitudinally from a proximal end to a distal end and including a lumen (132, 332) extending therethrough, the control member (108, 208, 308) longitudinally movable relative to the catheter (106, 206, 306) and including an abutment structure (120, 220, 320) proximate a distal end thereof; and a clip assembly (102, 202, 302) releasably coupleable to a distal end of the applicator (104, 204, 304), the clip assembly (102, 202, 302) including a pair of clip arms (110, 210, 310), each of the clip arms extending from a proximal end (136, 236) to a distal end, the proximal end (136, 236) of each of the clip arms (110, 210, 310) slidably received within a channel of a capsule (112, 212, 312) and configured to be releasably coupled to the distal end of the control member (108, 208, 308) so that the clip arms (110, 210, 310) are movable relative to the capsule (112, 212, 312) between a tissue receiving configuration, in which distal ends of the clip arms (110, 210, 310) are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another, the capsule (112, 212, 312) including proximal tabs (114, 214, 314) movable between a biased non-engaging configuration, in which the proximal tabs (114, 214, 314) extend into the channel, and an engaging configuration, in which the proximal tabs (114, 214, 314) extend laterally outward relative to a longitudinal axis of the capsule (112, 212, 312) to engage an engaging portion (218, 318) of the catheter (106, 206, 306), wherein the abutment structure (120, 220, 320) maintains an engagement with the proximal tabs (114, 214, 314), holding the proximal tabs (114, 214, 314) in the engaging configuration, while the abutment structure (120, 220, 320) is received within the capsule (112, 212, 312) characterised in that the clip arms (110, 210, 310) include a locking tab extending laterally outward therefrom and being configured to engage a portion of the capsule when the clip arms (110, 210, 310) have been drawn into the capsule by a predetermined distance, the locking tab being configured to lock the clip arms (110, 210, 310) in the tissue clipping configuration.