mhurhangee/ep-ind-claims huggingface dataset:
A charged linker of the formula wherein: Y represents a functional group that is capable of reaction with a cell-binding agent, the said functional group Y being selected from an N-hydroxysuccinimide ester, hydrazide, p-nitrophenyl esters, dinitrophenyl esters, pentafluorophenyl esters, pyridyldisulfides, nitropyridyldisulfides, maleimides, haloacetates and carboxylic acid chlorides; Z represents a functional group that enables linkage of a cytotoxic drug via a disulfide, thioether, thioester, peptide, hydrazone, ether, ester, carbamate, carbonate, amine (secondary, tertiary, or quarternary), imine, oximine, cycloheteroalkyl, heteroaromatic or amide bond, the said functional group Z being selected from thiol, disulfide, amino, carboxy, aldehydes, maleimido, haloacetyl, hydrazines and hydroxy; R 1, R 2, R 3, are the same or different and are linear alkyl having from 1-6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, linear, branched or cyclic alkenyl or alkynyl, or polyethyleneoxy with p unit(s) of formula (OCH 2 CH 2), wherein p is an integer from 1 to 1000, or combination thereof; R 4 and R 5 are the same or different and are H, linear alkyl having from 1-6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, linear, branched or cyclic alkenyl or alkynyl, or polyethyleneoxy with p unit(s) of formula (OCH 2 CH 2), wherein p is an integer from 1 to 1000, or combination thereof; M is H, or Na, or K, or -R 1 -P(=O) -R 2 -R 3 (R 4)(R 5)- is represented by one of the following structures: or or a pharmaceutical salt. Y represents a functional group that is capable of reaction with a cell-binding agent, the said functional group Y being selected from an N-hydroxysuccinimide ester, hydrazide, p-nitrophenyl esters, dinitrophenyl esters, pentafluorophenyl esters, pyridyldisulfides, nitropyridyldisulfides, maleimides, haloacetates and carboxylic acid chlorides; Z represents a functional group that enables linkage of a cytotoxic drug via a disulfide, thioether, thioester, peptide, hydrazone, ether, ester, carbamate, carbonate, amine (secondary, tertiary, or quarternary), imine, oximine, cycloheteroalkyl, heteroaromatic or amide bond, the said functional group Z being selected from thiol, disulfide, amino, carboxy, aldehydes, maleimido, haloacetyl, hydrazines and hydroxy; R 1, R 2, R 3, are the same or different and are linear alkyl having from 1-6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, linear, branched or cyclic alkenyl or alkynyl, or polyethyleneoxy with p unit(s) of formula (OCH 2 CH 2), wherein p is an integer from 1 to 1000, or combination thereof; R 4 and R 5 are the same or different and are H, linear alkyl having from 1-6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, linear, branched or cyclic alkenyl or alkynyl, or polyethyleneoxy with p unit(s) of formula (OCH 2 CH 2), wherein p is an integer from 1 to 1000, or combination thereof; M is H, or Na, or K, or -R 1 -P(=O) -R 2 -R 3 (R 4)(R 5)- is represented by one of the following structures: or or a pharmaceutical salt.
A method of preparing a dry powder inhaler pharmaceutical formulation, the method comprising: providing a first solution comprising a first solvent and an active agent, providing a second solution comprising a second solvent and at least one excipient; and removing the first and second solvents by simultaneously drying to a dry powder both the first and second solutions in a spray dryer having an external mixing three-fluid nozzle that produces one or more particles comprising both the active agent and the one or more excipient; wherein the first solvent is an organic solvent or a mixture containing at least an organic solvent and water and wherein the second solvent is water or a mixture containing at least water and an organic solvent.
A compound of Formula: wherein B' and B" together is a 3-indole Y is absent, R 3 and R 4 taken together with the nitrogen to which they are attached form a piperazine, unsubstituted or substituted with a methyl, ethyl, propyl, butyl, and R 1 and R 5 are hydrogen, R 2 is tetrahydrofurane, oxane (tetrahydropyrane), dioxane, methylene-tetrahydrofurane, methyleneoxane, methylene-dioxane, ethylene-tetrahydrofurane, ethylene-oxane, ethylene-dioxane. Y is absent, R 3 and R 4 taken together with the nitrogen to which they are attached form a piperazine, unsubstituted or substituted with a methyl, ethyl, propyl, butyl, and R 1 and R 5 are hydrogen, R 2 is tetrahydrofurane, oxane (tetrahydropyrane), dioxane, methylene-tetrahydrofurane, methyleneoxane, methylene-dioxane, ethylene-tetrahydrofurane, ethylene-oxane, ethylene-dioxane.
A relief valve, comprising: a floating piston configured to move reciprocally in a piston chamber in response to fluid pressure, with the piston chamber including a fluid inlet; a circumferential seal located on the floating piston and configured to substantially seal the floating piston to the piston chamber; a biasing device configured to keep the floating piston within a piston float movement range, wherein the fluid is held when the floating piston is within the piston float movement range and the fluid is exhausted when the floating piston exceeds the piston float movement range; characterised in that the valve further comprises one or more relief grooves formed in a sidewall of the piston chamber, with the one or more relief grooves being configured to conduct fluid around the floating piston and the circumferential seal when the floating piston is compressed beyond the piston float movement range in the piston chamber. a floating piston configured to move reciprocally in a piston chamber in response to fluid pressure, with the piston chamber including a fluid inlet; a circumferential seal located on the floating piston and configured to substantially seal the floating piston to the piston chamber; a biasing device configured to keep the floating piston within a piston float movement range, wherein the fluid is held when the floating piston is within the piston float movement range and the fluid is exhausted when the floating piston exceeds the piston float movement range; characterised in that the valve further comprises one or more relief grooves formed in a sidewall of the piston chamber, with the one or more relief grooves being configured to conduct fluid around the floating piston and the circumferential seal when the floating piston is compressed beyond the piston float movement range in the piston chamber.
Touring ski binding of a ski which can be adjusted between a climbing condition, where a ski boot or a boot plate carrying the ski boot is connected to the ski in a pivotable way only in the region of a tip of a boot, while the ski boot or the boot plate carrying the ski boot can be lifted from the ski at the heel portion, and a skiing condition where the ski boot or the boot plate carrying the ski boot is fixed at the ski in the region of the tip of the boot and at the heel portion of the ski boot or the boot plate carrying the ski boot, the touring ski binding having a climbing aid, comprising - a contact portion comprising a contact surface facing away from the ski for the heel portion of the ski boot or the boot plate, - an electric, pneumatic or hydraulic adjusting element (42; 42"; 221; 321 a, 321b; 442) with a base part (46; 46"; 224) to be fixed at the ski or at the ski binding and a movement part (48; 51"; 220; 320a, 320b; 448) which can be moved in relation to the latter, and - a movement conversion arrangement (18, 30) which converts the movement of the movement part (48; 51"; 448) of the adjusting element (42; 42"; 442) into a movement of the contact portion so that the height of the contact surface above the ski changes, or/and a locking arrangement (204; 304) converting the movement of the movement part (220; 320a, 320b) of the adjusting element (221; 321 a, 321 b) into locking or releasing the climbing aid so that an adjusted height of the contact surface above the ski is locked or released. - a contact portion comprising a contact surface facing away from the ski for the heel portion of the ski boot or the boot plate, - an electric, pneumatic or hydraulic adjusting element (42; 42"; 221; 321 a, 321b; 442) with a base part (46; 46"; 224) to be fixed at the ski or at the ski binding and a movement part (48; 51"; 220; 320a, 320b; 448) which can be moved in relation to the latter, and - a movement conversion arrangement (18, 30) which converts the movement of the movement part (48; 51"; 448) of the adjusting element (42; 42"; 442) into a movement of the contact portion so that the height of the contact surface above the ski changes, or/and a locking arrangement (204; 304) converting the movement of the movement part (220; 320a, 320b) of the adjusting element (221; 321 a, 321 b) into locking or releasing the climbing aid so that an adjusted height of the contact surface above the ski is locked or released.
A measuring arrangement for determining a diameter (d) of a workpiece structure having a central axis, the measuring arrangement comprising - a cutting tool including a cutting edge adapted to contact the workpiece structure, - a distance measuring device arranged to the cutting tool for measuring a distance (x) to a measurement point on a surface of the workpiece structure, and - a processor operatively coupled to the distance measuring device for determining the diameter (d) of the workpiece structure in a cross-section which extends through the measurement point and is perpendicular to the central axis, wherein the cutting tool is arrangeable at a reference position in which the cutting edge is located at a known position in relation to an engagement point on the surface of the workpiece structure, and the distance measuring device is configured to measure the distance (x) along a measurement direction from a measurement position to the measurement point on the surface, characterized in that the measurement point is spaced from the engagement point in a circumferential direction of the surface, and wherein the processor is configured to receive a distance measurement signal from the distance measuring device and determine the diameter on basis of the measured distance (x), the measurement direction, the reference position and the measurement position. - a cutting tool including a cutting edge adapted to contact the workpiece structure, - a distance measuring device arranged to the cutting tool for measuring a distance (x) to a measurement point on a surface of the workpiece structure, and - a processor operatively coupled to the distance measuring device for determining the diameter (d) of the workpiece structure in a cross-section which extends through the measurement point and is perpendicular to the central axis,
Method for operating a bus system for communication with a plurality of communication participants, in particular in a land vehicle and/or aircraft, each communication participant being assigned, in a static, cyclically recurring time window of fixed length, a time slot (16, 17) for transmitting user information having a byte count which is fixed during operation of the bus system and which can be defined at least once, characterised in that the time window has at least two coherent sub-time windows (14, 15), the same byte count being defined for all the time slots (16, 17) of one sub-time window (14, 15) and different byte counts being defined for time slots (16, 17) of different sub-time windows (14, 15).
Servo door closer, comprising - an output shaft, - a drive mechanism operatively connected to the output shaft, - a mechanical energy accumulator acting on the drive mechanism for storing closing energy for the door leaf, - a motor/generator unit operatively connected to the output shaft, and - an electrical energy accumulator electrically connected to the motor/generator unit for storing assisting energy for the door leaf, characterised in that the motor/generator unit is formed to assist a manual opening of the door leaf only in the door angle range of 0° to 45°, in particular only from 0° to 30°, in particular only from 0° to 25°, and the motor/generator unit is formed to assist a closure of the door leaf only in the door angle range of 0° to 45°, in particular only from 0° to 30°, in particular only from 0° to 25°. - an output shaft, - a drive mechanism operatively connected to the output shaft, - a mechanical energy accumulator acting on the drive mechanism for storing closing energy for the door leaf, - a motor/generator unit operatively connected to the output shaft, and - an electrical energy accumulator electrically connected to the motor/generator unit for storing assisting energy for the door leaf, the motor/generator unit is formed to assist a manual opening of the door leaf only in the door angle range of 0° to 45°, in particular only from 0° to 30°, in particular only from 0° to 25°, and the motor/generator unit is formed to assist a closure of the door leaf only in the door angle range of 0° to 45°, in particular only from 0° to 30°, in particular only from 0° to 25°.
A flange connection for mounting vacuum pumps (102,103), comprising an upper body configured to receive at least two stators, each stator being configured to create a pump chamber in which a respective rotor is to be housed, and each stator corresponding to a particular vacuum pump (102,103); a lower body configured to receive a motor of each vacuum pump (102,103), wherein the upper body and the lower body have openings though which respective drive shafts of the motors are insertable, the drive shafts to drive the rotors in the pump chambers; at least one inlet port for sucking air from a device where pressure is aimed to be lowered; and at least one duct (329,429) housed in the flange connection that is in fluid communication with the at least one inlet port; wherein the upper body further comprises a respective inlet hole (328,428,528) fluidly communicable with each pump chamber, the inlet holes (328,428,528) being in fluid communication with the at least one duct (329,429); and wherein the at least one duct (329,429) comprises flow control means configured to selectively let air pass from the at least one inlet port towards at least one of the pump chambers. an upper body configured to receive at least two stators, each stator being configured to create a pump chamber in which a respective rotor is to be housed, and each stator corresponding to a particular vacuum pump (102,103); a lower body configured to receive a motor of each vacuum pump (102,103), wherein the upper body and the lower body have openings though which respective drive shafts of the motors are insertable, the drive shafts to drive the rotors in the pump chambers; at least one inlet port for sucking air from a device where pressure is aimed to be lowered; and at least one duct (329,429) housed in the flange connection that is in fluid communication with the at least one inlet port; wherein the upper body further comprises a respective inlet hole (328,428,528) fluidly communicable with each pump chamber, the inlet holes (328,428,528) being in fluid communication with the at least one duct (329,429); and wherein the at least one duct (329,429) comprises flow control means configured to selectively let air pass from the at least one inlet port towards at least one of the pump chambers.
An electrical stimulation apparatus, inserted into a sample case comprising a plurality of holding units arranged therein for holding a sample including a cell, for applying a voltage to the cell, the electrical stimulation apparatus comprising: a plurality of electrode pairs, arranged therein, comprising a positive electrode and a negative electrode, characterized in that the negative electrode comprises a leading end extending further toward the holding unit than a leading end of the positive electrode by a predetermined distance of at least 1 pm but no more than 1.0 mm.
A filter, comprising: - a perimetric border frame, comprising a plurality of walls (21, 22, 23, 24) which delimit an accommodation region for a filtering pack; - a filtering pack accommodated in said accommodation region of the perimetric frame; characterized in that the filter comprises at least one thermal expansion compensator (4, 5) interposed between at least one of said walls (21, 22, 23, 24) of the frame and the filtering pack, wherein said at least one thermal expansion compensator (4, 5) comprises a sheet (43, 51) of a filtering medium which is folded onto itself and is coupled to the frame and to the filtering pack, a free edge of said sheet (43, 51) being furthermore folded around a corresponding wall (21, 22, 23, 24) of the frame coupled thereto. - a perimetric border frame, comprising a plurality of walls (21, 22, 23, 24) which delimit an accommodation region for a filtering pack; - a filtering pack accommodated in said accommodation region of the perimetric frame;
A vehicle-use rear combination lamp comprising: a first lamp portion which emits a first light; a second lamp portion which emits a second light; a common housing on which the first lamp portion and the second lamp portion are mounted; and a lens which integrally covers the first lamp portion and the second lamp portion, wherein the lens has a first lens portion to which the first light is irradiated and a second lens portion to which the second light is irradiated, the first lens portion is positioned vehicle forward of and below the second lens portion, a lower surface of a portion which connects the first lens portion and the second lens portion to each other extends substantially parallel to an optical axis of the second light, and wherein the second lamp portion is disposed vehicle forward of a front end of the lower surface; characterised in that the arr optical axis of the second light is inclined upwardly and rearwardly with respect to an optical axis of the first light. a first lamp portion which emits a first light; a second lamp portion which emits a second light; a common housing on which the first lamp portion and the second lamp portion are mounted; and a lens which integrally covers the first lamp portion and the second lamp portion, wherein the lens has a first lens portion to which the first light is irradiated and a second lens portion to which the second light is irradiated, the first lens portion is positioned vehicle forward of and below the second lens portion, a lower surface of a portion which connects the first lens portion and the second lens portion to each other extends substantially parallel to an optical axis of the second light, and wherein the second lamp portion is disposed vehicle forward of a front end of the lower surface; characterised in that the arr optical axis of the second light is inclined upwardly and rearwardly with respect to an optical axis of the first light.
A laundry dryer comprising a body, a drum provided in the body, in which the laundry items are loaded, a motor enabling rotating the drum, and a motor mount provided in the body, on which the motor is placed so as to enable supporting the motor from two sides, having a first bearer and a second bearer bearing the motor and a supporting portion extending in between the first bearer and the second bearer, characterized by at least one seat provided on the supporting portion, and an insulation member placed in the seat, enabling damping the vibrations emitted by the motor.
A comb copolymer comprising: A) one or more repeating units derived from at least one member selected from the group consisting of olefinically unsaturated anionic, anionogenic and zwitterionic comonomers; wherein anionic monomers includes salts of at least one of monomers with carboxylic or dicarboxylic acid groups, anhydrides, salts of phosphoric acid and salts of half-esters of dicarboxylic acids and B) one or more repeating units having the formula wherein Y is a moiety forming part of the copolymer backbone, Z is a moiety that exhibits association with other Z moieties or with other moieties within a formulation in which the copolymer will be employed, and b is a bond or moiety that links the Z moiety to the Y moiety; wherein the concentration of ionic and ionogenic repeats in the copolymer is between 10 and 400 meq per 100 grams of polymer, the weight of associative moieties Z is between 3 and 30 grams per 100 grams of polymer and the ratio of associative moieties Z to ionic and ionogenic repeats is between 0.025 and 1.3 A) one or more repeating units derived from at least one member selected from the group consisting of olefinically unsaturated anionic, anionogenic and zwitterionic comonomers; wherein anionic monomers includes salts of at least one of monomers with carboxylic or dicarboxylic acid groups, anhydrides, salts of phosphoric acid and salts of half-esters of dicarboxylic acids and B) one or more repeating units having the formula wherein Y is a moiety forming part of the copolymer backbone, Z is a moiety that exhibits association with other Z moieties or with other moieties within a formulation in which the copolymer will be employed, and b is a bond or moiety that links the Z moiety to the Y moiety; wherein the concentration of ionic and ionogenic repeats in the copolymer is between 10 and 400 meq per 100 grams of polymer, the weight of associative moieties Z is between 3 and 30 grams per 100 grams of polymer and the ratio of associative moieties Z to ionic and ionogenic repeats is between 0.025 and 1.3
A fluid ejection module mounting apparatus, comprising: a module mount having a horizontal portion and a vertical portion, the horizontal portion having an opening configured to receive a fluid ejection module and the vertical portion having a protruding portion, a fluid ejection module mounted to the module mount, and a clamp assembly comprising: a recessed portion, wherein the protruding portion of the module mount is configured to mate with the recessed portion, a clamp along a wall of the recessed portion, and a lever coupled to the clamp and configured to move the clamp from an open position to a closed position. a module mount having a horizontal portion and a vertical portion, the horizontal portion having an opening configured to receive a fluid ejection module and the vertical portion having a protruding portion, a fluid ejection module mounted to the module mount, and a clamp assembly comprising: a recessed portion, wherein the protruding portion of the module mount is configured to mate with the recessed portion, a clamp along a wall of the recessed portion, and a lever coupled to the clamp and configured to move the clamp from an open position to a closed position. a recessed portion, wherein the protruding portion of the module mount is configured to mate with the recessed portion, a clamp along a wall of the recessed portion, and a lever coupled to the clamp and configured to move the clamp from an open position to a closed position.