mhurhangee/ep-ind-claims huggingface dataset:
A method for synthesizing Etelcalcetide, comprising the steps of: step 1: synthesizing by solid-phase synthesis a peptide resin of fragment A, in which protecting groups are coupled to side chains of D-Cys and D-Arg in the amino acid sequence shown in SEQ ID NO: 1, an amino resin is coupled to C-terminus of the amino acid sequence shown in SEQ ID NO: 1 and N-terminus is acetylated; step 2: removing the protecting group from the side chain of D-Cys in the peptide resin of fragment A to obtain a peptide resin of fragment B; step 3: activating sulfhydryl group of the side chain of D-Cys in the peptide resin of fragment B with 2,2'-dithiodipyridine to obtain a peptide resin of fragment C; and step 4: coupling L-Cys coupled with a protecting group at the N-terminus thereof to the peptide resin of fragment C in a coupling system to construct a disulfide bond, obtaining a fully protected peptide resin, and adding a cleaving solution to remove all protecting groups and amino resin to obtain a crude peptide of Etelcalcetide. step 1: synthesizing by solid-phase synthesis a peptide resin of fragment A, in which protecting groups are coupled to side chains of D-Cys and D-Arg in the amino acid sequence shown in SEQ ID NO: 1, an amino resin is coupled to C-terminus of the amino acid sequence shown in SEQ ID NO: 1 and N-terminus is acetylated; step 2: removing the protecting group from the side chain of D-Cys in the peptide resin of fragment A to obtain a peptide resin of fragment B; step 3: activating sulfhydryl group of the side chain of D-Cys in the peptide resin of fragment B with 2,2'-dithiodipyridine to obtain a peptide resin of fragment C; and step 4: coupling L-Cys coupled with a protecting group at the N-terminus thereof to the peptide resin of fragment C in a coupling system to construct a disulfide bond, obtaining a fully protected peptide resin, and adding a cleaving solution to remove all protecting groups and amino resin to obtain a crude peptide of Etelcalcetide.
A method of reducing variation in blank measurement values in an in vitro immunoassay, comprising allowing a polyoxyethylene alkyl ether sulfate surfactant and a polyoxyethylene sorbitan fatty acid ester surfactant to coexist in a reaction system, wherein said polyoxyethylene alkyl ether sulfate has a concentration of 0.0005 to 0.25 w/w%, and wherein said polyoxyethylene sorbitan fatty acid ester has a concentration of 0.0005 to 0.005 w/w%. wherein said polyoxyethylene alkyl ether sulfate has a concentration of 0.0005 to 0.25 w/w%, and wherein said polyoxyethylene sorbitan fatty acid ester has a concentration of 0.0005 to 0.005 w/w%.
A method for selecting a diversity control channel in a network communication system, comprising: monitoring by a communication device received signals to identify a plurality of neighbor nodes of interest, NOI, which utilize two or more control channel sets, each comprising a plurality of diversity control channels, each diversity control channel respectively defined by a sub-band having a predetermined frequency range; estimating by the communication device a received control channel power respectively associated with each NOI in a plurality of the diversity control channels which are actively in use by the NOI; obtain a composite NOI signal power for each of the diversity control channels by summing the received control channel power for the plurality of NOI within each sub-band; for each of the diversity control channels, using the composite NOI signal power and information comprising a total power present in each sub-band to determine an interference power that is exclusively associated with unknown interference and noise in the sub-band; and within each control channel set, selecting a preferred diversity control channel from the plurality of diversity control channels which has the interference power of least magnitude. monitoring by a communication device received signals to identify a plurality of neighbor nodes of interest, NOI, which utilize two or more control channel sets, each comprising a plurality of diversity control channels, each diversity control channel respectively defined by a sub-band having a predetermined frequency range; estimating by the communication device a received control channel power respectively associated with each NOI in a plurality of the diversity control channels which are actively in use by the NOI; obtain a composite NOI signal power for each of the diversity control channels by summing the received control channel power for the plurality of NOI within each sub-band; for each of the diversity control channels, using the composite NOI signal power and information comprising a total power present in each sub-band to determine an interference power that is exclusively associated with unknown interference and noise in the sub-band; and within each control channel set, selecting a preferred diversity control channel from the plurality of diversity control channels which has the interference power of least magnitude.
A blade mount configured to couple a blade to a rotatable shaft, the blade mount comprising: a blade mount base configured to contact at least a portion of the blade; a latch assembly disposed proximate to the blade mount base to secure the blade to the blade mount base responsive to operation of the latch assembly; wherein the blade mount is characterized by the latch assembly comprising a clamp operably coupled to the blade mount base and configured to rotate about an axis of rotation; a blade reception channel configured to enclose at least a portion of the blade and being defined by the latch assembly, the blade reception channel being formed between the blade mount base and the clamp of the latch assembly; and at least one magnet receptacle disposed at the blade mount base and a corresponding at least one magnet disposed therein to attract the blade toward the blade mount base prior to operation of the latch assembly, wherein the blade mount base comprises a set of guide posts and a set of locking posts disposed on opposing sides of the blade reception channel, and wherein the clamp further comprises a locking assembly and a latch cover, the locking assembly enabling the latch cover to be secured to hold the clamp proximate to the blade via engagement of a wire element with the set of locking posts. a blade mount base configured to contact at least a portion of the blade; a latch assembly disposed proximate to the blade mount base to secure the blade to the blade mount base responsive to operation of the latch assembly; wherein the blade mount is characterized by the latch assembly comprising a clamp operably coupled to the blade mount base and configured to rotate about an axis of rotation; a blade reception channel configured to enclose at least a portion of the blade and being defined by the latch assembly, the blade reception channel being formed between the blade mount base and the clamp of the latch assembly; and at least one magnet receptacle disposed at the blade mount base and a corresponding at least one magnet disposed therein to attract the blade toward the blade mount base prior to operation of the latch assembly, wherein the blade mount base comprises a set of guide posts and a set of locking posts disposed on opposing sides of the blade reception channel, and wherein the clamp further comprises a locking assembly and a latch cover, the locking assembly enabling the latch cover to be secured to hold the clamp proximate to the blade via engagement of a wire element with the set of locking posts.
A transmucosal patch comprising electrospun fibers comprising a biocompatible polymer and a therapeutically effective amount of a pharmaceutical active ingredient, wherein the active pharmaceutical ingredient comprises a cannabinoid or a cannabinoid and an opioid.
A laminate structure for forming a package, the laminate structure comprising: a first film layer defining a first surface configured to be disposed proximate a product stored within a package, the first film layer further defining a second surface opposite the first surface, wherein the first film layer includes an uncut laser-distorted region; a second film layer defining a first surface laminated to the second surface of the first film layer and a second surface opposite the first surface of the second film layer, wherein the second film layer includes an inner laser score line extending between the first and second surfaces of the second film layer; and a third film layer defining a first surface laminated to the second surface of the second film layer and a second surface opposite the first surface of the third film layer, wherein the third film layer includes an outer score line extending between the first and second surfaces of the third film layer, wherein the inner laser score line is in line with the laser-distorted region, and the outer score line is offset from the inner laser score line and the laser-distorted region, such that peeling back the third film layer at the outer score line causes the first film layer to break along the laser-distorted region to form a first film layer cut line continuous with the inner laser score line to allow the first film layer and the second film layer to be moved together with the third film layer. a first film layer defining a first surface configured to be disposed proximate a product stored within a package, the first film layer further defining a second surface opposite the first surface, wherein the first film layer includes an uncut laser-distorted region; a second film layer defining a first surface laminated to the second surface of the first film layer and a second surface opposite the first surface of the second film layer, wherein the second film layer includes an inner laser score line extending between the first and second surfaces of the second film layer; and a third film layer defining a first surface laminated to the second surface of the second film layer and a second surface opposite the first surface of the third film layer, wherein the third film layer includes an outer score line extending between the first and second surfaces of the third film layer, wherein the inner laser score line is in line with the laser-distorted region, and the outer score line is offset from the inner laser score line and the laser-distorted region, such that peeling back the third film layer at the outer score line causes the first film layer to break along the laser-distorted region to form a first film layer cut line continuous with the inner laser score line to allow the first film layer and the second film layer to be moved together with the third film layer.
A fitness apparatus, comprising: a first frame; a second frame pivotally connected to the first frame; a nose part, wherein the nose part and the second frame are coaxially pivotally connected to the first frame; a linear elastic element having a first end and a second end, wherein the first end is connected to the first frame; and a cable having a connecting end connected to the second end of the linear elastic element, wherein the cable is pressed against the nose part, characterized in that the cable has a force-applying end driving the second frame; and when the second frame pivotally swings against the first frame, the second frame pulls the cable and changes a length of the cable pressed against the nose part, whereby the linear elastic element is stretched or shortened by the cable. a first frame; a second frame pivotally connected to the first frame; a nose part, wherein the nose part and the second frame are coaxially pivotally connected to the first frame; a linear elastic element having a first end and a second end, wherein the first end is connected to the first frame; and a cable having a connecting end connected to the second end of the linear elastic element, wherein the cable is pressed against the nose part, characterized in that the cable has a force-applying end driving the second frame; and when the second frame pivotally swings against the first frame, the second frame pulls the cable and changes a length of the cable pressed against the nose part, whereby the linear elastic element is stretched or shortened by the cable.
System comprising an earth-drilling device for moving a drill string for the introduction of an earth borehole in the earth and a detection device which is designed to detect the drill string at the end, characterized in that the detection device is arranged in the region of a target pit, wherein the detection device is designed to determine the presence of the drill string in a target pit.
An electrically non-conductive back plate for supporting the back of a patient in a supine position, comprising on its front face facing the back of the patient a pair or more of ECG electrodes (105, 132; 102, 135), said pair or more of ECG electrodes capable of maintaining electrically conductive skin contact with the patient's back; wherein a line connecting said at least one pair of the one pair or more of ECG electrodes is comprised by an angle β of 45°±25° formed with the projection S of the spine of a person of which the chest is supported by the back plate; wherein each ECG electrode of said one pair or more of ECG electrodes (105, 132; 102, 135) is mounted in a recess in the front face of the back plate and wherein each ECG electrode comprises an electrically conductive electrode disk, and a flexible conducting means for connecting the electrode disk with an ECG monitoring unit; wherein a resiliently compressible spring means is disposed in said recess between the bottom thereof and the electrode disk, and wherein each ECG electrode is displaceable in said recess in a lateral direction.
A compound loop antenna, comprising: a magnetic loop located on a first plane and generating a magnetic field, the magnetic loop including a downstream portion and an upstream portion, the downstream portion separated from the upstream portion by a first capacitive gap that capacitively feeds the downstream portion of the magnetic loop, wherein the first capacitive gap adds a first capacitive reactance to a total capacitive reactance of the antenna; an electric field radiator located on the first plane, the electric field radiator coupled to the magnetic loop and configured to emit an electric field orthogonal to the magnetic field, wherein a total inductive reactance of the antenna substantially matches the total capacitive reactance; a radiator feed located on the first plane and coupled to the magnetic loop via a first electrical trace; and wherein the electric field radiator is coupled to the magnetic loop via a second electrical trace positioned on a second plane below the first plane, the electric field radiator positioned adjacent to the radiator feed and separated from the radiator feed by a second capacitive gap that capacitively feeds the electric field radiator, wherein the second capacitive gap has a second capacitive reactance adding to the total capacitive reactance. a magnetic loop located on a first plane and generating a magnetic field, the magnetic loop including a downstream portion and an upstream portion, the downstream portion separated from the upstream portion by a first capacitive gap that capacitively feeds the downstream portion of the magnetic loop, wherein the first capacitive gap adds a first capacitive reactance to a total capacitive reactance of the antenna; an electric field radiator located on the first plane, the electric field radiator coupled to the magnetic loop and configured to emit an electric field orthogonal to the magnetic field, wherein a total inductive reactance of the antenna substantially matches the total capacitive reactance; a radiator feed located on the first plane and coupled to the magnetic loop via a first electrical trace; and wherein the electric field radiator is coupled to the magnetic loop via a second electrical trace positioned on a second plane below the first plane, the electric field radiator positioned adjacent to the radiator feed and separated from the radiator feed by a second capacitive gap that capacitively feeds the electric field radiator, wherein the second capacitive gap has a second capacitive reactance adding to the total capacitive reactance.
An apparatus for use in a borehole intersecting an earth formation, the apparatus comprising: a downhole tool (600, 601) comprising an outer member (698, 699) configured for conveyance in the borehole; a pressure barrel (696, 697) positioned inside the outer member; a substantially cylindrical pod (604, 604') positioned inside the pressure barrel, the pod comprising: at least one rigid outer surface (605, 605') forming an exterior surface of the pod and supported by a central frame (206, 306) extending across a diameter of the pod; at least one downhole electronic component (210, 310) mounted between the exterior surface and the frame. a downhole tool (600, 601) comprising an outer member (698, 699) configured for conveyance in the borehole; a pressure barrel (696, 697) positioned inside the outer member; a substantially cylindrical pod (604, 604') positioned inside the pressure barrel, the pod comprising: at least one rigid outer surface (605, 605') forming an exterior surface of the pod and supported by a central frame (206, 306) extending across a diameter of the pod; at least one downhole electronic component (210, 310) mounted between the exterior surface and the frame. at least one rigid outer surface (605, 605') forming an exterior surface of the pod and supported by a central frame (206, 306) extending across a diameter of the pod; at least one downhole electronic component (210, 310) mounted between the exterior surface and the frame.
Alcohol rectification plant with at least one rectification column, to which the alcohol-water mixture to be rectified can be supplied as a feed stream with an initial alcohol concentration of at least 30 percent by volume of the mixture and the top alcohol vapour of which can be used for supplying energy to a reboiler of a column of the plant, characterized in that the top alcohol vapour of the rectification column can additionally be used for supplying energy to an evaporator which evaporates at least part of the alcohol-water mixture to be rectified, in that the part of the alcohol-water mixture evaporated in the evaporator is supplied to the rectification column as a feed stream via a compressor, and in that a separator separating the top alcohol vapour into a vapour portion and a liquid portion is arranged downstream of the evaporator in the top alcohol vapour path of the evaporator and in that the reboiler is associated to the rectification column and in that the vapour portion separated by the separator can be supplied to the reboiler of the rectification column via another compressor for energy supply to the latter.
An orthodontic member, which has a tube shape, a hollow polygonal prism shape, a hollow truncated polygonal pyramid shape, a hollow truncated cone shape, or a funnel shape, and consists of a water-soluble or biodegradable material, wherein the orthodontic member has a mark (100, 200, 300) formed thereon, and wherein the mark includes at least one selected from among a center mark representing a center in a longitudinal direction of the orthodontic member, a working mark representing a length from the center of the orthodontic member, and an end mark representing an end of the orthodontic member.
A polyphenylene ether comprising a repeating unit derived from a phenol of the formula: (in the formula, R 13 is an optionally substituted saturated or unsaturated hydrocarbon group having a carbon number of 15, R 11 and R 12 are each independently one of a hydrogen atom, a linear saturated hydrocarbon group having a carbon number of 1 to 12, and substituents represented by the following formula, where R 11 and R 12 cannot be both hydrogen atoms): (in the formula, each R 31 is independently an optionally substituted linear alkyl group having a carbon number of 1 to 8, or atoms in the two R 31 are bonded together to form a cyclic alkyl group with a carbon number of 1 to 8, each R 32 is independently an optionally substituted alkylene group having a carbon number of 1 to 8, b is each independently 0 or 1, and R 33 is a hydrogen atom, an optionally substituted alkyl group having a carbon number of 1 to 8, or an optionally substituted phenyl group).
A substrate-sheet fabricating method comprising: a cutting step of cutting into a group of small pieces a base substrate whose first-side surface is attached to a first sheet member; a transferring step of, after the cutting step, transferring the group of small pieces to a second sheet member by attaching the second sheet member to second-side surfaces of the group of small pieces and by peeling off the first sheet member from the first-side surfaces of the group of small pieces; further characterized in a contracting step of making the first sheet member or the second sheet member contract in a direction along a surface thereof, wherein in a case where the first sheet member is made to contract in the contracting step, the contracting step is performed before the transferring step, and in a case where the second sheet member is made to contract in the contracting step, the contracting step is performed after the transferring step. a cutting step of cutting into a group of small pieces a base substrate whose first-side surface is attached to a first sheet member; a transferring step of, after the cutting step, transferring the group of small pieces to a second sheet member by attaching the second sheet member to second-side surfaces of the group of small pieces and by peeling off the first sheet member from the first-side surfaces of the group of small pieces; further characterized in a contracting step of making the first sheet member or the second sheet member contract in a direction along a surface thereof, wherein in a case where the first sheet member is made to contract in the contracting step, the contracting step is performed before the transferring step, and in a case where the second sheet member is made to contract in the contracting step, the contracting step is performed after the transferring step.