A method of predicting outcome of treatment of a vessel of a patient, comprising: calculating a pressure ratio based on pressure measurements obtained (510,610) from a first instrument and a second instrument positioned within the vessel of the patient, while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel; co-registering the calculated pressure ratio with obtained angiography data; outputting (550,650) to a display device a visual representation (1100,1200,2100,2200) including: the calculated pressure ratio curve associated with locations within the vessel based on the co-registered angiographic data along with a graphical representation of at least one stent (1002,2202), and/or the calculated pressure ratio overlaid on the angiography data along with the graphical representation of the at least one stent (902,2102) positioned in the vessel; receiving (560,660) a user input to modify a position and/or a length of the at least one stent to a virtual/simulated situation; determining a predicted pressure ratio (1210,2210) for the virtual/simulated situation based on the modified position (1102,1202) and/or length (2104,2204) of the at least one stent, the calculated pressure ratio and the associated angiography data; outputting (570,670) to the display device the predicted pressure ratio (1210,2210) along with the modified position (1102,1202) and/or length (2104,2204) of the at least one stent; updating the visual representation (1100,1200,2100,2200), in response to the predicted pressure ratio (1210,2210) and the modified position (1102,1202) and/or length (2104,2204) of the at least one stent for evaluating the predicted outcome of the treatment; and correlating the virtual/simulated characteristics of the graphical representation of the stent with the co-registered angiography data to determine real physiological parameters for the at least one stent to be deployed in the vessel. calculating a pressure ratio based on pressure measurements obtained (510,610) from a first instrument and a second instrument positioned within the vessel of the patient, while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel; co-registering the calculated pressure ratio with obtained angiography data; outputting (550,650) to a display device a visual representation (1100,1200,2100,2200) including: the calculated pressure ratio curve associated with locations within the vessel based on the co-registered angiographic data along with a graphical representation of at least one stent (1002,2202), and/or the calculated pressure ratio overlaid on the angiography data along with the graphical representation of the at least one stent (902,2102) positioned in the vessel; the calculated pressure ratio curve associated with locations within the vessel based on the co-registered angiographic data along with a graphical representation of at least one stent (1002,2202), and/or the calculated pressure ratio overlaid on the angiography data along with the graphical representation of the at least one stent (902,2102) positioned in the vessel; receiving (560,660) a user input to modify a position and/or a length of the at least one stent to a virtual/simulated situation; determining a predicted pressure ratio (1210,2210) for the virtual/simulated situation based on the modified position (1102,1202) and/or length (2104,2204) of the at least one stent, the calculated pressure ratio and the associated angiography data; outputting (570,670) to the display device the predicted pressure ratio (1210,2210) along with the modified position (1102,1202) and/or length (2104,2204) of the at least one stent; updating the visual representation (1100,1200,2100,2200), in response to the predicted pressure ratio (1210,2210) and the modified position (1102,1202) and/or length (2104,2204) of the at least one stent for evaluating the predicted outcome of the treatment; and correlating the virtual/simulated characteristics of the graphical representation of the stent with the co-registered angiography data to determine real physiological parameters for the at least one stent to be deployed in the vessel.