A pharmaceutical delivery device comprising: a housing having a first end and a second end spaced in an axial direction; a pharmaceutical containing needled syringe mounted within said housing to be movable in said axial direction from a first position to a second position, wherein an injection tip of the syringe needle is recessed within said housing when in said first position and projects from said housing beyond said first end when in said second position; and a syringe advancing assembly (90, 96) operable to automatically advance said needled syringe from said first position to said second position; and characterized in that the device further comprises a plunger including an input portion projecting from said housing for manual access by a user, wherein said plunger is operable by the user directly shifting said input portion when said needled syringe is disposed in said second position to inject pharmaceutical from said syringe through said needle at a rate adjustably controlled by a user during said injection, wherein said plunger includes a plunger extender automatically movable within said housing from a first location to a second location upon said needled syringe advancing from said first position to said second position, wherein said plunger extender, when in said second location, occupies a space vacated by said needled syringe during advancement from said first position to said second position, whereby said plunger input portion remains stationary relative to said housing during said advancement of said needled syringe, wherein said plunger extender is operatively connected with said syringe advancing assembly to be advanced proximally in an amount and at a time the same as said needled syringe is advanced from said first position to said second position, wherein said plunger extender and a shaft portion of said plunger comprise a telescopic connection, and wherein said extender and said plunger shaft portion are configured to axially fix said plunger shaft portion and said plunger extender together at the end of the advancement of said plunger extender with said needled syringe. a housing having a first end and a second end spaced in an axial direction; a pharmaceutical containing needled syringe mounted within said housing to be movable in said axial direction from a first position to a second position, wherein an injection tip of the syringe needle is recessed within said housing when in said first position and projects from said housing beyond said first end when in said second position; and a syringe advancing assembly (90, 96) operable to automatically advance said needled syringe from said first position to said second position; and characterized in that the device further comprises a plunger including an input portion projecting from said housing for manual access by a user, wherein said plunger is operable by the user directly shifting said input portion when said needled syringe is disposed in said second position to inject pharmaceutical from said syringe through said needle at a rate adjustably controlled by a user during said injection, wherein said plunger includes a plunger extender automatically movable within said housing from a first location to a second location upon said needled syringe advancing from said first position to said second position, wherein said plunger extender, when in said second location, occupies a space vacated by said needled syringe during advancement from said first position to said second position, whereby said plunger input portion remains stationary relative to said housing during said advancement of said needled syringe, wherein said plunger extender is operatively connected with said syringe advancing assembly to be advanced proximally in an amount and at a time the same as said needled syringe is advanced from said first position to said second position, wherein said plunger extender and a shaft portion of said plunger comprise a telescopic connection, and wherein said extender and said plunger shaft portion are configured to axially fix said plunger shaft portion and said plunger extender together at the end of the advancement of said plunger extender with said needled syringe.