mhurhangee/ep-ind-claims huggingface dataset:
A computer-implemented method of measuring an amount of cells of a particular cell lineage in a biological sample, the method comprising: detecting a first number of methylated or unmethylated DNA fragments in a cell-free mixture of the biological sample at one or more differentially-methylated regions based on signals obtained from an assay, the cell-free mixture including cell-free DNA from a plurality of cell lineages, each of the one or more differentially-methylated regions specific to the particular cell lineage by being hypomethylated or hypermethylated relative to other cell lineages; determining a first methylation level using the first number; obtaining one or more calibration data points, wherein each calibration data point specifies an amount of cells of the particular cell lineage and a calibration methylation level, and wherein the one or more calibration data points are determined from a plurality of calibration samples; comparing the first methylation level to a calibration methylation level of at least one calibration data point; and estimating the amount of cells of the particular cell lineage in the biological sample based on the comparing. detecting a first number of methylated or unmethylated DNA fragments in a cell-free mixture of the biological sample at one or more differentially-methylated regions based on signals obtained from an assay, the cell-free mixture including cell-free DNA from a plurality of cell lineages, each of the one or more differentially-methylated regions specific to the particular cell lineage by being hypomethylated or hypermethylated relative to other cell lineages; determining a first methylation level using the first number; obtaining one or more calibration data points, wherein each calibration data point specifies an amount of cells of the particular cell lineage and a calibration methylation level, and wherein the one or more calibration data points are determined from a plurality of calibration samples; comparing the first methylation level to a calibration methylation level of at least one calibration data point; and estimating the amount of cells of the particular cell lineage in the biological sample based on the comparing.
Machine for producing and dispensing products such as ice cream, iced beverages or granita, comprising a removable product-containing tank which is provided at its front end with a tap for dispensing the product and which, via its rear opening, sealingly houses a cooling element with a substantially horizontal axis and a motor-driven mixer element which rotates coaxially with the cooling element so as to keep the product stirred and push it towards the dispensing tap, the tank being removable from the machine by means of extraction from its operating position in a disassembly direction which is substantially parallel to the axis of the cooling element, characterized in that the tank has a bottom surface which faces a corresponding seat on the base of the machine and in that snap-engaging means for locking the movement of the tank in the said disassembly direction are provided between said seat and the tank, said means being able to be manually released by means of operation of at least one operating lever.
An electronic module comprising: a rigid and thermally conductive frame including a center panel and a surrounding transverse peripheral edge; an electronics board mounted to one side of said frame, said electronics board carrying a plurality of electronic components; a power board mounted to an opposite side of said frame, said power board carrying a plurality of replaceable power elements, each said power element comprising one of fuses and a relay; and a housing enclosing said electronics board and said power board, said housing including an access cover to said power board, characterized in that said electronic module includes a cantilever arranged mounting flange for mounting the module to a bulkhead, that the fuses and/or relay are mounted on the side of the power board facing the access cover such that the access cover provides access to the fuses and/or relay, and that the frame is a metal frame and configured to provide a barrier for electromagnetic radiation between said electronics board and said power board. a rigid and thermally conductive frame including a center panel and a surrounding transverse peripheral edge; an electronics board mounted to one side of said frame, said electronics board carrying a plurality of electronic components; a power board mounted to an opposite side of said frame, said power board carrying a plurality of replaceable power elements, each said power element comprising one of fuses and a relay; and a housing enclosing said electronics board and said power board, said housing including an access cover to said power board, characterized in that said electronic module includes a cantilever arranged mounting flange for mounting the module to a bulkhead, that the fuses and/or relay are mounted on the side of the power board facing the access cover such that the access cover provides access to the fuses and/or relay, and that the frame is a metal frame and configured to provide a barrier for electromagnetic radiation between said electronics board and said power board.
A metal complex of Formula for use in the treatment of Parkinson's disease or amyotropic sclerosis, where: the complex is symmetrical; M is Cu; R 1 and R 5 are each hydrogen; R 2 and R 6 are each methyl, ethyl, or phenyl; and R 3 and R 4 are each methyl. the complex is symmetrical; M is Cu; R 1 and R 5 are each hydrogen; R 2 and R 6 are each methyl, ethyl, or phenyl; and R 3 and R 4 are each methyl.
A Radio Frequency reflection type phase shifter, the phase shifter comprising a coupler for input and output, and N variable capacitors, where N is an integer value of 2 or more, each of the variable capacitors providing in use radio frequency reflection, each of the variable capacitors being connected to the coupler by at least one impedance transformer (K, 26), the characteristic impedances of the impedance transformers having been selected so that the phase shifter provides a phase shift at least substantially proportional to the value of N, characterised in that each of the variable capacitors comprises electrochromic material. the phase shifter comprising a coupler for input and output, and N variable capacitors, where N is an integer value of 2 or more, each of the variable capacitors providing in use radio frequency reflection, each of the variable capacitors being connected to the coupler by at least one impedance transformer (K, 26), the characteristic impedances of the impedance transformers having been selected so that the phase shifter provides a phase shift at least substantially proportional to the value of N, characterised in that each of the variable capacitors comprises electrochromic material.
A fastening apparatus for surgical retaining systems, comprising a retaining element and a fastening element, which can be mechanically connected to each other, wherein the retaining element comprises a joint socket and the fastening element comprises a joint head, wherein the joint socket and the joint head are shaped corresponding to each other and form a ball-and-socket joint, wherein the movement of the ball-and-socket joint can be locked by means of a clamping element, characterized in that, the clamping element is an eccentric ring which, when turned, wedges the joint head with respect to the joint socket.
A PYY compound comprising L-beta-homoarginine at a position corresponding to position 35 of hPYY (SEQ ID NO:1), and a pharmaceutically acceptable salt thereof.
A tungsten sputtering target, wherein an area ratio (a) of crystal grains having a plane oriented to within 15° of a sputtering surface is 30% or less, an area ratio (b) of crystal grains having a plane oriented to within 15° of a sputtering surface is 30% or less, an area ratio (c) of crystal grains having a plane oriented to within 15° of a sputtering surface is 30% or less, and an area ratio (d) of all crystal grains orientations other than those providing the area ratios (a) to (c) is 46% or more, each area ratio being obtained by an analysis of a cross section perpendicular to the sputtering surface with an inverse pole figure mapping using electron backscatter diffraction, and each area ratio being equal to (area of crystal grains having the respective orientation / area of crystal grains for all orientations)×100 (%).
Carbon having a bimodal microporous/mesoporous or microporous/macroporous pore size distribution for use in the extracorporeal removal of cytokines, uremic toxins, liver toxins and other biologically active molecules including bacterial endotoxin and exotoxin from whole blood without prior separation of the blood into cells and plasma, characterized in that the carbon is: surface structure activated and in bead form; haemocompatible and in uncoated form; wherein the carbon is formed from carbonization and activation of a phenolic resin via a process comprising curing mesoporous resin made by a process comprising condensing: a pore former; a nucleophilic component consisting of novolac; and 15-20 pbw hexamine per 100 parts of the nucleophilic component; and wherein microporous refers to carbon having pores with a diameter <2 nm, mesoporous refers to carbon having pores with a diameter from 2 nm to 50 nm and macroporous refers to carbon having pores with a diameter of larger than 50 nm. surface structure activated and in bead form; haemocompatible and in uncoated form; wherein the carbon is formed from carbonization and activation of a phenolic resin via a process comprising curing mesoporous resin made by a process comprising condensing: a pore former; a nucleophilic component consisting of novolac; and 15-20 pbw hexamine per 100 parts of the nucleophilic component; and wherein microporous refers to carbon having pores with a diameter <2 nm, mesoporous refers to carbon having pores with a diameter from 2 nm to 50 nm and macroporous refers to carbon having pores with a diameter of larger than 50 nm.
A string light engine comprising: a flexible insulated electrical conductor; a first support comprising a dielectric layer and circuitry; a first IDC connector extending away from the first support and in electrical communication with the circuitry of the first support, the first IDC connector comprising a terminal (60, 62, 66, 68) that is inserted into the conductor to provide an electrical connection between the conductor and the circuitry of the first support; a first LED mounted on the first support and in electrical communication with the circuitry of the first support; and characterized in that the string light engine further comprises a first overmolded housing at least substantially surrounding the first support and a portion of the conductor adjacent the first support. a flexible insulated electrical conductor; a first support comprising a dielectric layer and circuitry; a first IDC connector extending away from the first support and in electrical communication with the circuitry of the first support, the first IDC connector comprising a terminal (60, 62, 66, 68) that is inserted into the conductor to provide an electrical connection between the conductor and the circuitry of the first support; a first LED mounted on the first support and in electrical communication with the circuitry of the first support; and characterized in that the string light engine further comprises a first overmolded housing at least substantially surrounding the first support and a portion of the conductor adjacent the first support.
Ship propulsion unit comprising drive devices to be disposed in the hull and an underwater pod with a front propeller and a rear propeller to be placed outside the hull, wherein the front propeller and the rear propeller are disposed on opposite sides of the underwater pod, and torque-transmitting devices between the drive devices and the propellers, wherein the torque-transmitting devices contain a torque-transmitting shaft shared by both propellers for transmitting torque from the drive devices into the underwater pod, characterized in that the torque-transmitting device moreover comprise, disposed in the underwater pod, - front transmission devices, which contain a front ring gear and, in engagement therewith, an associated front pinion gear (R o) which is coupled to the torque-transmitting shaft, wherein the front ring gear is coupled to the front propeller, and - rear transmission devices, which contain a rear ring gear and, in engagement therewith, an associated rear pinion gear (R u) which is coupled to the torque-transmitting shaft, wherein the rear ring gear is coupled to the rear propeller, and that the front ring gear-front pinion gear pair and the rear ring gear-rear pinion gear pair each contain a gear reduction for achieving at least approximately the full torque on the respective propeller. - front transmission devices, which contain a front ring gear and, in engagement therewith, an associated front pinion gear (R o) which is coupled to the torque-transmitting shaft, wherein the front ring gear is coupled to the front propeller, and - rear transmission devices, which contain a rear ring gear and, in engagement therewith, an associated rear pinion gear (R u) which is coupled to the torque-transmitting shaft, wherein the rear ring gear is coupled to the rear propeller, and
A wireless communications device comprising: a first transceiver chain including an input to receive a first timing signal, and including a first frequency divider to generate a first local oscillator, LO, signal by reducing a frequency of the first timing signal to a first carrier frequency; and a second transceiver chain including inputs to receive the first timing signal and a second timing signal, and further including: a second frequency divider to generate a second LO signal by reducing the frequency of the first timing signal to the first carrier frequency; a third frequency divider to generate a third LO signal by reducing a frequency of the second timing signal to a second carrier frequency; and a first multiplexer to select either the second LO signal or the third LO signal for transmitting wireless signals via the second transceiver chain based at least in part on a mode select signal indicating an operating mode of the wireless communications device. a first transceiver chain including an input to receive a first timing signal, and including a first frequency divider to generate a first local oscillator, LO, signal by reducing a frequency of the first timing signal to a first carrier frequency; and a second transceiver chain including inputs to receive the first timing signal and a second timing signal, and further including: a second frequency divider to generate a second LO signal by reducing the frequency of the first timing signal to the first carrier frequency; a third frequency divider to generate a third LO signal by reducing a frequency of the second timing signal to a second carrier frequency; and a first multiplexer to select either the second LO signal or the third LO signal for transmitting wireless signals via the second transceiver chain based at least in part on a mode select signal indicating an operating mode of the wireless communications device. a second frequency divider to generate a second LO signal by reducing the frequency of the first timing signal to the first carrier frequency; a third frequency divider to generate a third LO signal by reducing a frequency of the second timing signal to a second carrier frequency; and a first multiplexer to select either the second LO signal or the third LO signal for transmitting wireless signals via the second transceiver chain based at least in part on a mode select signal indicating an operating mode of the wireless communications device.
An ocean bottom seismic data collection system characterised in that it comprises: a. a disk-shaped, water tight case formed of two plates (26, 28) that are parallel to one another, wherein each of the two plates have a circular shape and are joined along their peripheries by a wall to define at least one internal compartment; b. at least one geophone disposed within the at least one internal compartment of said case; c. a clock disposed within the at least one internal compartment of said case; d. a seismic data recorder disposed within the at least one internal compartment of said case; e. a power source disposed within the at least one internal compartment of said case; and f. a latching mechanism attached to the wall; wherein said system has having a negative buoyancy. a. a disk-shaped, water tight case formed of two plates (26, 28) that are parallel to one another, wherein each of the two plates have a circular shape and are joined along their peripheries by a wall to define at least one internal compartment; b. at least one geophone disposed within the at least one internal compartment of said case; c. a clock disposed within the at least one internal compartment of said case; d. a seismic data recorder disposed within the at least one internal compartment of said case; e. a power source disposed within the at least one internal compartment of said case; and f. a latching mechanism attached to the wall; wherein said system has having a negative buoyancy.
An aircraft refueling device, this device comprising a deformable pipe for the circulation of fuel, the downstream end of which is provided with a wing fastener for the connection thereof onto an intake port of an aircraft fuel tank, this device comprising a first sensor for measuring the pressure values, in the vicinity of the wing fastener, of a fuel flow in the deformable pipe, as well as a member for determining the rate of the flow in the deformable pipe, characterized in that the refueling device further comprises at least: - a second sensor for measuring the pressure values of the flow upstream of the deformable pipe; and - a unit is provided for calculating the value (ΔP1) of the pressure drop (ΔP) of the flow in the deformable pipe, based on the pressure values (P1, P2) measured by the first and second sensors (501, 52); and - a unit for comparing this calculated pressure drop value (ΔP1) with a reference value (ΔP0) established for the same flow rate. - a second sensor for measuring the pressure values of the flow upstream of the deformable pipe; and - a unit is provided for calculating the value (ΔP1) of the pressure drop (ΔP) of the flow in the deformable pipe, based on the pressure values (P1, P2) measured by the first and second sensors (501, 52); and - a unit for comparing this calculated pressure drop value (ΔP1) with a reference value (ΔP0) established for the same flow rate.
A scroll compressor comprising a crankshaft to mutually engage a stationary scroll having a whirlpool shape on a base plate and an orbiting scroll, and drive the orbiting scroll; a suction chamber and a compression chamber formed between the orbiting scroll and the stationary scroll by the orbital motion of the orbiting scroll accompanying the rotation of the crankshaft; and a back pressure chamber included on the back surface of the orbital scroll to apply a pressing force for pressing the stationary scroll to the orbital scroll by a pressure that is higher than the suction chamber pressure; and further comprising a communication path in the stationary scroll for connecting the suction chamber or the compression chamber and the back pressure chamber; and a back pressure control means for opening and closing the communication path by way of the pressure differential along the communication path, wherein the inlet communication path extending from the back pressure control means of the communication path to the back pressure chamber includes at least two or more path cross-sectional areas, and the cross-sectional area of the inlet communication path on the back pressure chamber side on the inlet communication path is formed larger than the cross-sectional area of an inlet communication path on the back pressure control means side, characterized in that the scroll compressor is configured so that the opening surface area of the back pressure chamber side of the inlet communication path on the back pressure chamber side is always equal to or smaller than the cross-sectional area of the inlet communication path on the back pressure control means side, by the base plate of the orbiting scroll always blocking part of the back pressure chamber side opening of the inlet communication path on the back pressure chamber side.
Device for coupling and decoupling an external door handle, having a handle spindle for actuating a door lock, having two coupling elements (1, 2), which are mounted in a housing such that they can be rotated about an axis of rotation and can be moved from a release position into a rotationally fixed coupling position by virtue of a coupling protrusion, which is assigned to a coupling catch mounted on a coupling member about a pivot axis about a in the transverse direction in relation to the axis of rotation, engaging in a coupling recess, and having an actuating member, which can be pivoted by a housing-mounted, electromotive drive and, in a neutral rotary position of the coupling member, which bears the coupling catch, acts, by way of an actuating portion (12, 12', 13, 13'), on a drive portion of the coupling catch in order to pivot the latter into the coupling position or the release position, wherein the drive portion detaches from the actuating portion (12, 13) as a result of the actuating member acting eccentrically, as seen in relation to the axis of rotation, on the coupling catch upon rotation of the coupled coupling members (1, 2), wherein the drive portion is formed by a drive arm which projects radially outwards from the coupling catch, characterized in that the actuating member has two essentially parallel resilient limbs, which act on two opposite sides of the drive arm.
A semiconductor device comprising: an N-ch normally-off transistor including a first source connected to a source terminal, a first drain, and a first gate connected to a gate terminal; an N-ch normally-on transistor including a second source connected to the first drain, a second drain connected to a drain terminal, and a second gate, wherein the normally-on transistor is a HEMT formed of GaN based semiconductor, and wherein the normally-on transistor is provided with a gate insulating film; characterised by a level shift element connected to the second gate and connected to the gate terminal and provided between the gate terminal and the second gate, the level shift element having a shift voltage, the level shift element configured to lower a voltage on the second gate with respect to the voltage applied to the gate terminal by an amount of the shift voltage when the semiconductor device is turned on, wherein the level shift element is a first zener diode, wherein an anode of the first zener diode is connected to the second gate, and a cathode of the first zener diode is connected to the gate terminal. an N-ch normally-off transistor including a first source connected to a source terminal, a first drain, and a first gate connected to a gate terminal; an N-ch normally-on transistor including a second source connected to the first drain, a second drain connected to a drain terminal, and a second gate, wherein the normally-on transistor is a HEMT formed of GaN based semiconductor, and wherein the normally-on transistor is provided with a gate insulating film; characterised by a level shift element connected to the second gate and connected to the gate terminal and provided between the gate terminal and the second gate, the level shift element having a shift voltage, the level shift element configured to lower a voltage on the second gate with respect to the voltage applied to the gate terminal by an amount of the shift voltage when the semiconductor device is turned on, wherein the level shift element is a first zener diode, wherein an anode of the first zener diode is connected to the second gate, and a cathode of the first zener diode is connected to the gate terminal.