A computer-implemented method of quantifying a specimen contained within a specimen container, comprising: providing a specimen contained within a specimen container, wherein the specimen is a centrifuged specimen including a settled blood portion and a serum or plasma portion; capturing, by a plurality of cameras (440A-440C), images of the specimen at multiple spectra having different nominal wavelengths, and at multiple different exposure times; selection of optimally-exposed pixels from the images at the multiple different exposure times and at each of the multiple spectra to generate optimally-exposed image data for each of the multiple spectra and for each camera (440A - 440C), wherein for each corresponding pixel and for each of the exposure time images pixels exhibiting optimal image intensity are selected from each of the different exposure time images, wherein pixels of optimal image intensity are defined as pixels falling within an intensity range between 180 - 254 on a scale of 0 - 255, wherein, if more than one pixel in the corresponding locations of two images is determined to be optimally exposed, the higher of the two is selected; using statistical data on the optimally exposed image data, classifying the specimen by a multi-class classifier into various class types comprising one or more of serum or plasma portion, settled blood portion, gel separator, if the gel separator is used, air, tube, label, or cap; and quantifying the specimen by determining, according to the classification, one or more of: a location of a liquid-air, LA, interface between the air and the serum or plasma portion, a location of a serum-blood interface between the serum or plasma portion and the settled blood portion, a location of a serum-gel interface between the serum or plasma portion and the gel separator, if the gel separator is used, a location of a blood-gel interface between the settled blood portion and the gel separator, if the gel separator is used, a volume of the serum or plasma portion, or a volume of the settled blood portion, wherein the capturing images of the specimen at the multiple spectra and the multiple exposures times is conducted from multiple different viewpoints, with each camera of the plurality of cameras (440A, 440B, 440C) provided at each viewpoint. providing a specimen contained within a specimen container, wherein the specimen is a centrifuged specimen including a settled blood portion and a serum or plasma portion; capturing, by a plurality of cameras (440A-440C), images of the specimen at multiple spectra having different nominal wavelengths, and at multiple different exposure times; selection of optimally-exposed pixels from the images at the multiple different exposure times and at each of the multiple spectra to generate optimally-exposed image data for each of the multiple spectra and for each camera (440A - 440C), wherein for each corresponding pixel and for each of the exposure time images pixels exhibiting optimal image intensity are selected from each of the different exposure time images, wherein pixels of optimal image intensity are defined as pixels falling within an intensity range between 180 - 254 on a scale of 0 - 255, wherein, if more than one pixel in the corresponding locations of two images is determined to be optimally exposed, the higher of the two is selected; using statistical data on the optimally exposed image data, classifying the specimen by a multi-class classifier into various class types comprising one or more of serum or plasma portion, settled blood portion, gel separator, if the gel separator is used, air, tube, label, or cap; and quantifying the specimen by determining, according to the classification, one or more of: a location of a liquid-air, LA, interface between the air and the serum or plasma portion, a location of a serum-blood interface between the serum or plasma portion and the settled blood portion, a location of a serum-gel interface between the serum or plasma portion and the gel separator, if the gel separator is used, a location of a blood-gel interface between the settled blood portion and the gel separator, if the gel separator is used, a volume of the serum or plasma portion, or a volume of the settled blood portion, wherein the capturing images of the specimen at the multiple spectra and the multiple exposures times is conducted from multiple different viewpoints, with each camera of the plurality of cameras (440A, 440B, 440C) provided at each viewpoint. a location of a liquid-air, LA, interface between the air and the serum or plasma portion, a location of a serum-blood interface between the serum or plasma portion and the settled blood portion, a location of a serum-gel interface between the serum or plasma portion and the gel separator, if the gel separator is used, a location of a blood-gel interface between the settled blood portion and the gel separator, if the gel separator is used, a volume of the serum or plasma portion, or a volume of the settled blood portion, wherein the capturing images of the specimen at the multiple spectra and the multiple exposures times is conducted from multiple different viewpoints, with each camera of the plurality of cameras (440A, 440B, 440C) provided at each viewpoint.