mhurhangee/ep-ind-claims huggingface dataset:
A compound having structural Formula I or a pharmaceutically acceptable salt thereof wherein: ring A is aryl, wherein the aryl ring is unsubstituted or substituted by R 6 5- or 6-membered heteroaryl, containing 1-3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the heteroaryl ring is substituted by R 6, or fused tricyclic heteroaryl, containing 2-6 N heteroatoms; R 1 is hydrogen, or (C 1-3)alkyl; R 2a and R 2b are independently hydrogen, or (C 1-3)alkyl; R 3 is hydrogen, or (C 1-3)alkyl; R 4 is hydrogen, (C 1-6)alkyl, hydroxy(C 1-6)alkyl, (C 1-3)alkylC N(R 7) 2, or (C 1-3)alkyl-heteroaryl, wherein heteroaryl is a 5- or 6-membered monocyclic ring and contains 1-3 heteroatoms independently selected from the group consisting of N, O, and S; each R 5 is oxo (C 1-3)alkyl, or halo; R 6 is a five-membered heteroaryl containing 1-4 heteroatoms independently selected from the group consisting of N, O, and S; each R 7 is hydrogen, or (C 1-3)alkyl; X is -(C 1-3)alkyl-, optionally substituted by hydroxy; and n is 0, 1, 2, or 3. ring A is aryl, wherein the aryl ring is unsubstituted or substituted by R 6 5- or 6-membered heteroaryl, containing 1-3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the heteroaryl ring is substituted by R 6, or fused tricyclic heteroaryl, containing 2-6 N heteroatoms; aryl, wherein the aryl ring is unsubstituted or substituted by R 6 5- or 6-membered heteroaryl, containing 1-3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the heteroaryl ring is substituted by R 6, or fused tricyclic heteroaryl, containing 2-6 N heteroatoms; R 1 is hydrogen, or (C 1-3)alkyl; hydrogen, or (C 1-3)alkyl; R 2a and R 2b are independently hydrogen, or (C 1-3)alkyl; hydrogen, or (C 1-3)alkyl; R 3 is hydrogen, or (C 1-3)alkyl; hydrogen, or (C 1-3)alkyl; R 4 is hydrogen, (C 1-6)alkyl, hydroxy(C 1-6)alkyl, (C 1-3)alkylC N(R 7) 2, or (C 1-3)alkyl-heteroaryl, wherein heteroaryl is a 5- or 6-membered monocyclic ring and contains 1-3 heteroatoms independently selected from the group consisting of N, O, and S; hydrogen, (C 1-6)alkyl, hydroxy(C 1-6)alkyl, (C 1-3)alkylC N(R 7) 2, or (C 1-3)alkyl-heteroaryl, wherein heteroaryl is a 5- or 6-membered monocyclic ring and contains 1-3 heteroatoms independently selected from the group consisting of N, O, and S; each R 5 is oxo (C 1-3)alkyl, or halo; oxo (C 1-3)alkyl, or halo; R 6 is a five-membered heteroaryl containing 1-4 heteroatoms independently selected from the group consisting of N, O, and S; each R 7 is hydrogen, or (C 1-3)alkyl; hydrogen, or (C 1-3)alkyl; X is -(C 1-3)alkyl-, optionally substituted by hydroxy; and n is 0, 1, 2, or 3.
An antenna frame for a microstrip array antenna suitable for a vehicle, the antenna frame being intended to reduce radar-cross section of the vehicle when the antenna and the antenna frame are attached to the vehicle, characterised in that - the antenna frame is arranged to surround an antenna aperture periphery; - the antenna frame comprises a transition region that has a tapering profile with a bevelled side of a first width when seen in cross section and in a direction from the surrounding antenna frame towards a so formed recess wherein the antenna is intended to be placed, and wherein; - a first absorbent material is attached to the bevelled side of the tapering profile. - the antenna frame is arranged to surround an antenna aperture periphery; - the antenna frame comprises a transition region that has a tapering profile with a bevelled side of a first width when seen in cross section and in a direction from the surrounding antenna frame towards a so formed recess wherein the antenna is intended to be placed, and wherein; - a first absorbent material is attached to the bevelled side of the tapering profile.
A jewelry element for forming an article of jewelry comprising: first and second gemstones, each having a lower pavilion and an upper crown, said crown having a multifaceted side and said pavilion having a bottom surface; at least one link, said link having a spacer for separating said gemstones (64, 66) one from the other in an opposed spaced relationship; and a leaf member defined by first and second angularly directed leaf arms, said arms forming a v-configuration, said first arm abutting at least a portion of the multifaceted side of said first gemstone and said second arm abutting at least a portion of the multifaceted side of said second gemstone securing the gemstone between sidewalls of the spacer and leaf arm surfaces. first and second gemstones, each having a lower pavilion and an upper crown, said crown having a multifaceted side and said pavilion having a bottom surface; at least one link, said link having a spacer for separating said gemstones (64, 66) one from the other in an opposed spaced relationship; and a leaf member defined by first and second angularly directed leaf arms, said arms forming a v-configuration, said first arm abutting at least a portion of the multifaceted side of said first gemstone and said second arm abutting at least a portion of the multifaceted side of said second gemstone securing the gemstone between sidewalls of the spacer and leaf arm surfaces.
A method of computer memory management, the method comprising: accessing a memory pool table, the memory pool table including entries that describe a plurality of memory pools, each memory pool representing memory pages related by common attributes, and each memory pool associated with a virtual machine index; accessing a per-page tracking table, each entry in the per-page tracking table to relate a memory page with virtual machine indices of the memory pool table; scanning each entry in the per-page tracking table and, for each entry: determining an amount of memory released if the memory page related with the entry is swapped; and aggregating the amount of memory for the respective virtual machine related with the memory page related with the entry in the per-page tracking table, to produce a per-virtual machine memory aggregate using the respective virtual machine index; and outputting the per-virtual machine memory aggregate for virtual machines related with the memory pages in the per-page tracking table. accessing a memory pool table, the memory pool table including entries that describe a plurality of memory pools, each memory pool representing memory pages related by common attributes, and each memory pool associated with a virtual machine index; accessing a per-page tracking table, each entry in the per-page tracking table to relate a memory page with virtual machine indices of the memory pool table; scanning each entry in the per-page tracking table and, for each entry: determining an amount of memory released if the memory page related with the entry is swapped; and aggregating the amount of memory for the respective virtual machine related with the memory page related with the entry in the per-page tracking table, to produce a per-virtual machine memory aggregate using the respective virtual machine index; and outputting the per-virtual machine memory aggregate for virtual machines related with the memory pages in the per-page tracking table. determining an amount of memory released if the memory page related with the entry is swapped; and aggregating the amount of memory for the respective virtual machine related with the memory page related with the entry in the per-page tracking table, to produce a per-virtual machine memory aggregate using the respective virtual machine index; and outputting the per-virtual machine memory aggregate for virtual machines related with the memory pages in the per-page tracking table.
A method for nucleic acid amplification comprising: a) providing an input sample comprising target nucleic acid molecules; b) contacting the input sample with a reaction mixture comprising a solid phase and a liquid phase, wherein: i. the solid phase comprises a plurality of first amplification primers immobilized on a solid support, the first amplification primers capable of specifically hybridizing to a first sequence of the target nucleic acid molecules, and ii. the liquid phase comprises a plurality of second amplification primers in solution, the plurality of second primers capable of specifically hybridizing to a second sequence of the target nucleic acid molecules; c) amplifying the target nucleic acid molecules under isothermal conditions such that substantially all of the first amplification primers are incorporated into amplification products, wherein the plurality of first amplification primers is provided in an amount which limits the yield of amplification products to a predefined amount, and the plurality of second amplification primers is provided in an amount that exceeds the amount of the first amplification primers. a) providing an input sample comprising target nucleic acid molecules; b) contacting the input sample with a reaction mixture comprising a solid phase and a liquid phase, wherein: i. the solid phase comprises a plurality of first amplification primers immobilized on a solid support, the first amplification primers capable of specifically hybridizing to a first sequence of the target nucleic acid molecules, and ii. the liquid phase comprises a plurality of second amplification primers in solution, the plurality of second primers capable of specifically hybridizing to a second sequence of the target nucleic acid molecules; i. the solid phase comprises a plurality of first amplification primers immobilized on a solid support, the first amplification primers capable of specifically hybridizing to a first sequence of the target nucleic acid molecules, and ii. the liquid phase comprises a plurality of second amplification primers in solution, the plurality of second primers capable of specifically hybridizing to a second sequence of the target nucleic acid molecules; c) amplifying the target nucleic acid molecules under isothermal conditions such that substantially all of the first amplification primers are incorporated into amplification products, wherein the plurality of first amplification primers is provided in an amount which limits the yield of amplification products to a predefined amount, and the plurality of second amplification primers is provided in an amount that exceeds the amount of the first amplification primers.
A method of electronic ticket processing, comprising the steps of: receiving, a ticket object that includes a ticket key encrypted with a content encryption key according to a networked pre-existing digital rights management system; receiving a rights object compatible with said digital rights management system, and including one or more usage restrictions corresponding to the ticket object and including the content encryption key encrypted with a digital rights management key associated with a digital rights management agent installed in an electronic device in which the ticket object and the rights object are received, the digital rights management agent operating as part of the networked pre-existing digital rights management system; and redeeming said ticket object, using at least one ticket agent installed in said electronic device, by: requesting, by the ticket agent, the digital rights management agent to check the rights object for usage restrictions and, if ticket usage is permitted, to decrypt the ticket object; wherein the ticket object and the associated rights object are formatted according to said pre-existing digital rights management system and are handled by the digital rights management agent in the same manner that it handles other digital rights management restricted objects; retrieving, by the ticket agent, said ticket key from the digital rights management agent, subject to the one or more usage restrictions; communicating, by the ticket agent, with an external agent according to a predefined verification protocol, to verify possession of the ticket key, without exposing the ticket key to the external agent. requesting, by the ticket agent, the digital rights management agent to check the rights object for usage restrictions and, if ticket usage is permitted, to decrypt the ticket object; wherein the ticket object and the associated rights object are formatted according to said pre-existing digital rights management system and are handled by the digital rights management agent in the same manner that it handles other digital rights management restricted objects; retrieving, by the ticket agent, said ticket key from the digital rights management agent, subject to the one or more usage restrictions; communicating, by the ticket agent, with an external agent according to a predefined verification protocol, to verify possession of the ticket key, without exposing the ticket key to the external agent.
An apparatus for generating X-rays, comprising: - a cathode; - an anode; - at least one power supply; - an electron detector; and - a processing unit; wherein, the at least one power supply is configured to produce a voltage between the cathode and the anode; wherein, the at least one power supply is configured to provide the cathode with a cathode current; wherein, the cathode is positioned relative to the anode, and the cathode and anode are operable such that electrons emitted from the cathode interact with the anode with energies corresponding to the voltage, and wherein the electrons interact with the anode at a focal spot to generate X-rays; wherein, the electron detector is positioned relative to the anode, and is configured to measure a backscatter electron signal from the anode; wherein, the electron detector is configured to provide the measured backscatter electron signal to the processing unit; characterized in that the processing unit is configured to determine a cathode current correction and/or a correction to the voltage between the cathode and the anode, the determination comprises utilization of the measured backscatter electron signal and a correlation between anode surface roughness and backscatter electron emission; and that the processing unit is configured to provide the cathode current correction and/or the correction to the voltage between the cathode and the anode to the at least one power supply. - a cathode; - an anode; - at least one power supply; - an electron detector; and - a processing unit;
A method for identifying methylation status of a nucleic acid analyte in a biological sample which is a tissue sample, the method comprising: (a) contacting the biological sample with an array comprising a plurality of capture probes, wherein a capture probe in the plurality of capture probes comprises (i) a spatial barcode and (ii) a capture domain comprising at least one methylated cytosine; (b) deaminating the nucleic acid analyte in the biological sample; (c) contacting the nucleic acid analyte with a plurality of probes comprising a first probe and a second probe, wherein the first probe comprises (i) a sequence complementary to at least a first sequence of the nucleic acid analyte and (ii) a sequence complementary to the capture domain; and the second probe comprises a sequence complementary to at least a second sequence of the nucleic acid analyte; (d) ligating the first probe and the second probe, thereby generating a ligation product; (e) hybridizing the ligation product to the capture probe; (f) extending the capture probe using the ligation product as a template; thereby generating an extended capture probe; and (g) determining (i) the sequence of the spatial barcode or the complement thereof, and (ii) all or a portion of the sequence of the extended capture probe, or a complement thereof, and using the determined sequences of (i) and (ii) to identify the methylation status of the nucleic acid analyte in the biological sample. (a) contacting the biological sample with an array comprising a plurality of capture probes, wherein a capture probe in the plurality of capture probes comprises (i) a spatial barcode and (ii) a capture domain comprising at least one methylated cytosine; (b) deaminating the nucleic acid analyte in the biological sample; (c) contacting the nucleic acid analyte with a plurality of probes comprising a first probe and a second probe, wherein the first probe comprises (i) a sequence complementary to at least a first sequence of the nucleic acid analyte and (ii) a sequence complementary to the capture domain; and the second probe comprises a sequence complementary to at least a second sequence of the nucleic acid analyte; the first probe comprises (i) a sequence complementary to at least a first sequence of the nucleic acid analyte and (ii) a sequence complementary to the capture domain; and the second probe comprises a sequence complementary to at least a second sequence of the nucleic acid analyte; (d) ligating the first probe and the second probe, thereby generating a ligation product; (e) hybridizing the ligation product to the capture probe; (f) extending the capture probe using the ligation product as a template; thereby generating an extended capture probe; and (g) determining (i) the sequence of the spatial barcode or the complement thereof, and (ii) all or a portion of the sequence of the extended capture probe, or a complement thereof, and using the determined sequences of (i) and (ii) to identify the methylation status of the nucleic acid analyte in the biological sample.
Socket block for forming a patchboard, having a box-shaped housing, having two end faces and four side faces (4a, 4b, 4c, 4d) which extend between the end faces, wherein the two end faces each have at least one terminal region, wherein all side faces (4a, 4b, 4c, 4d) each have at least one tongue or at least one groove, and at least one corresponding groove or tongue for connection to the tongue or groove of another socket block is formed in the respective opposite side face, and wherein a connecting element is formed on the at least one tongue, and the at least one groove has a corresponding counter-connecting element characterized in that the tongue has at least one latching element (18, 20) at its front end in the assembly direction, and that a latching recess (19, 24) or latching opening corresponding to the latching element (18, 20) is formed in the housing at the end of the corresponding groove. wherein all side faces (4a, 4b, 4c, 4d) each have at least one tongue or at least one groove, and at least one corresponding groove or tongue for connection to the tongue or groove of another socket block is formed in the respective opposite side face, and wherein a connecting element is formed on the at least one tongue, and the at least one groove has a corresponding counter-connecting element characterized in that the tongue has at least one latching element (18, 20) at its front end in the assembly direction, and that a latching recess (19, 24) or latching opening corresponding to the latching element (18, 20) is formed in the housing at the end of the corresponding groove.
An application synchronization method of a terminal, the application synchronization method comprising: acquiring a synchronization period timing of a new application, if the new application is registered for synchronization; acquiring synchronization timings and synchronization period for each previously registered application for synchronization; identifying an earliest synchronization timing, which will occur after registration of the new application, for each previously registered application; selecting one earliest synchronization timing based on the synchronization period of the new application and the synchronization period of each previously registered application, wherein the selected earliest synchronization timing is within a first synchronization period of the new application; and setting a first occurring synchronization timing of the new application to the selected earliest synchronization timing. acquiring a synchronization period timing of a new application, if the new application is registered for synchronization; acquiring synchronization timings and synchronization period for each previously registered application for synchronization; identifying an earliest synchronization timing, which will occur after registration of the new application, for each previously registered application; selecting one earliest synchronization timing based on the synchronization period of the new application and the synchronization period of each previously registered application, wherein the selected earliest synchronization timing is within a first synchronization period of the new application; and setting a first occurring synchronization timing of the new application to the selected earliest synchronization timing.
A heat pump system, comprising: a compressor configured to compress a refrigerant; a heating heat exchanger configured to exchange heat between the refrigerant compressed by the compressor and a heating medium; a decompressor configured to decompress the refrigerant; an evaporator configured to exchange heat between the refrigerant decompressed by the decompressor and outside air; outside air temperature detection means configured to detect outside air temperature; outlet temperature detection means configured to detect outlet temperature, the outlet temperature being temperature of the heating medium flowing out from the heating heat exchanger; compressor control means configured to control an operating frequency of the compressor; characterized in that the compressor control means is configured to control an operating frequency of the compressor in accordance with a sum of a fundamental frequency and a correction frequency; and the heat pump system further comprises fundamental frequency calculation means configured to calculate the fundamental frequency in accordance with a temperature difference obtained by subtracting current outlet temperature from target outlet temperature and in accordance with current outside air temperature; and first correction means configured to add a positive first correction value to the correction frequency when the temperature difference is larger than a positive first reference value and a temporal variation in the outlet temperature is smaller than a reference. a compressor configured to compress a refrigerant; a heating heat exchanger configured to exchange heat between the refrigerant compressed by the compressor and a heating medium; a decompressor configured to decompress the refrigerant; an evaporator configured to exchange heat between the refrigerant decompressed by the decompressor and outside air; outside air temperature detection means configured to detect outside air temperature; outlet temperature detection means configured to detect outlet temperature, the outlet temperature being temperature of the heating medium flowing out from the heating heat exchanger; compressor control means configured to control an operating frequency of the compressor; characterized in that the compressor control means is configured to control an operating frequency of the compressor in accordance with a sum of a fundamental frequency and a correction frequency; and the heat pump system further comprises fundamental frequency calculation means configured to calculate the fundamental frequency in accordance with a temperature difference obtained by subtracting current outlet temperature from target outlet temperature and in accordance with current outside air temperature; and first correction means configured to add a positive first correction value to the correction frequency when the temperature difference is larger than a positive first reference value and a temporal variation in the outlet temperature is smaller than a reference.