mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a compound having Formula I, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystal forms, its individual tautomers or a pharmaceutically acceptable salt thereof, for use in lowering intraocular pressure in an affected eye of a human patient in need of such treatment by administering a therapeutically effective amount of said composition; wherein R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H, C 1-10 alkyl, heterocycle or aryl; and R is C 1-10 alkyl, heterocycle or aryl, wherein "alkyl" means a saturated monovalent alkane moiety having straight or branched alkane moieties or combinations thereof, which may optionally be substituted by amino groups, aryl groups, halogens, and one methylene (-CH 2 -) can be replaced by carbonyl, -NH-, carboxyl, amide, sulfur or by oxygen, and "heterocycle" means an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic ring containing at least one heteroatom selected from O or N or S or combinations thereof, interrupting the carbocyclic ring structure, which may optionally be substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), -S(C 1-6 alkyl) groups, and "aryl" means an organic moiety derived from an aromatic hydrocarbon consisting of a monocyclic or bicyclic ring containing 6-10 carbon atoms by removal of one hydrogen atom, such as phenyl or naphthyl, which may optionally be substituted by, but not limited to, C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), - C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), and -S(C 1-6 alkyl) groups. R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H, C 1-10 alkyl, heterocycle or aryl; and R is C 1-10 alkyl, heterocycle or aryl, wherein "alkyl" means a saturated monovalent alkane moiety having straight or branched alkane moieties or combinations thereof, which may optionally be substituted by amino groups, aryl groups, halogens, and one methylene (-CH 2 -) can be replaced by carbonyl, -NH-, carboxyl, amide, sulfur or by oxygen, and "heterocycle" means an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic ring containing at least one heteroatom selected from O or N or S or combinations thereof, interrupting the carbocyclic ring structure, which may optionally be substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), -S(C 1-6 alkyl) groups, and "aryl" means an organic moiety derived from an aromatic hydrocarbon consisting of a monocyclic or bicyclic ring containing 6-10 carbon atoms by removal of one hydrogen atom, such as phenyl or naphthyl, which may optionally be substituted by, but not limited to, C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), - C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), and -S(C 1-6 alkyl) groups.
A method for selectively powering a battery-operated drug-delivery device, the device having a battery and a battery circuit, said method comprising: providing a battery isolator disposed in a first position whereat the isolator contacts a battery terminal so as to interrupt the battery circuit, such that no power is provided to the device; and activating a fastening mechanism of the device, the fastening mechanism configured for fastening the device to the skin of a user, characterized in that: said activating causes movement of the battery isolator to a second position whereat the battery circuit is uninterrupted by the isolator, such that power is provided to the device. providing a battery isolator disposed in a first position whereat the isolator contacts a battery terminal so as to interrupt the battery circuit, such that no power is provided to the device; and activating a fastening mechanism of the device, the fastening mechanism configured for fastening the device to the skin of a user, characterized in that: said activating causes movement of the battery isolator to a second position whereat the battery circuit is uninterrupted by the isolator, such that power is provided to the device. said activating causes movement of the battery isolator to a second position whereat the battery circuit is uninterrupted by the isolator, such that power is provided to the device.
A method of preparing a passive device powder formulation, wherein glycopyrrolate particles are co-milled with magnesium stearate, lactose particles are separately co-milled with magnesium stearate, and the co-milled glycopyrrolate and lactose particles are then combined.
A method for ranking power distribution network assets in a power distribution network, based on downstream events, the method comprising: receiving communications from one or more sensors in the power distribution network, the communications indicating the occurrence of a network event; calculating a probability of a power distribution network asset causing a problem indicated by the event for each power distribution network asset in an affected area of the power distribution network; characterised by calculating a spread probability of the power distribution network asset causing the problem for each power distribution network asset in the affected area of the power distribution network; based on the probability and the spread probability, calculating a probability of the power distribution network asset malfunctioning for each power distribution network asset in the affected area of the power distribution network; comparing the probability of the power distribution network asset malfunctioning for each power distribution network asset in the affected area of the power distribution network to a threshold value; based on the comparison, determining a power distribution network asset having a highest probability of malfunctioning; and based on the determination, controlling one of more other power distribution network assets to mitigate the problem. receiving communications from one or more sensors in the power distribution network, the communications indicating the occurrence of a network event; calculating a probability of a power distribution network asset causing a problem indicated by the event for each power distribution network asset in an affected area of the power distribution network; characterised by calculating a spread probability of the power distribution network asset causing the problem for each power distribution network asset in the affected area of the power distribution network; based on the probability and the spread probability, calculating a probability of the power distribution network asset malfunctioning for each power distribution network asset in the affected area of the power distribution network; comparing the probability of the power distribution network asset malfunctioning for each power distribution network asset in the affected area of the power distribution network to a threshold value; based on the comparison, determining a power distribution network asset having a highest probability of malfunctioning; and based on the determination, controlling one of more other power distribution network assets to mitigate the problem.
A gas turbine engine comprising: a fan section defining a fan airflow pathway; a combustor section; a turbine section in fluid communication with the combustor section; a fan thrust reverser; and an exhaust section comprising: an exhaust plug including a plurality of exhaust plug apertures circumferentially spaced from each other; an exhaust nozzle radially offset from the exhaust plug defining an exhaust pathway between the exhaust plug and the exhaust nozzle; and an exhaust plug liner positioned along an inner surface of the exhaust plug, the exhaust plug liner having a non-uniform outer surface axially aligned with the exhaust plug apertures; wherein the exhaust plug liner is rotatable relative to exhaust plug between a first position and a second position to selectively increase a cross-sectional area of the exhaust pathway during thrust reversal operation of the thrust reverser to increase an amount of reverse thrust. a fan section defining a fan airflow pathway; a combustor section; a turbine section in fluid communication with the combustor section; a fan thrust reverser; and an exhaust section comprising: an exhaust plug including a plurality of exhaust plug apertures circumferentially spaced from each other; an exhaust nozzle radially offset from the exhaust plug defining an exhaust pathway between the exhaust plug and the exhaust nozzle; and an exhaust plug liner positioned along an inner surface of the exhaust plug, the exhaust plug liner having a non-uniform outer surface axially aligned with the exhaust plug apertures; an exhaust plug including a plurality of exhaust plug apertures circumferentially spaced from each other; an exhaust nozzle radially offset from the exhaust plug defining an exhaust pathway between the exhaust plug and the exhaust nozzle; and an exhaust plug liner positioned along an inner surface of the exhaust plug, the exhaust plug liner having a non-uniform outer surface axially aligned with the exhaust plug apertures; wherein the exhaust plug liner is rotatable relative to exhaust plug between a first position and a second position to selectively increase a cross-sectional area of the exhaust pathway during thrust reversal operation of the thrust reverser to increase an amount of reverse thrust.
A remote user interface for connection with an audiologic test apparatus with an ear probe for audiologic testing of a patient, comprising a remote user interface housing accommodating a first mechanically non-latching switch for alternating selection of one of the right ear and left ear of a patient for testing with the audiologic test apparatus, wherein the remote user interface housing is different from a housing of the audiologic test apparatus; and wherein the remote user interface housing is configured for mechanical connection with the ear probe of the audiologic test apparatus in such a way that the remote user interface will be located proximate the patient during the audiologic testing of the patient, and characterized in that the remote user interface housing accommodates a second mechanically non-latching switch configured for controlling start and stop of testing with the audiologic test apparatus. a remote user interface housing accommodating a first mechanically non-latching switch for alternating selection of one of the right ear and left ear of a patient for testing with the audiologic test apparatus, wherein the remote user interface housing is different from a housing of the audiologic test apparatus; and wherein the remote user interface housing is configured for mechanical connection with the ear probe of the audiologic test apparatus in such a way that the remote user interface will be located proximate the patient during the audiologic testing of the patient, and characterized in that the remote user interface housing accommodates a second mechanically non-latching switch configured for controlling start and stop of testing with the audiologic test apparatus.
A lift-assisted mobility device for assisting the motion of or supporting a body of a mammal having a body weight moving between a seated position and a standing position, such device comprising: (a) a pressure-tight suit adapted to being worn over at least one part of the mammal's body having at least one opening for inserting the body part into the suit; (b) means for providing a pressure-tight seal connected adjacent to the opening of the suit for operative engagement of the body part surface of the mammal; (c) inlet means in the suit for introduction of at least one source of positive pressure or vacuum to an interior of the suit between the mammal body and the suit to create a differential pressure condition therein between the positive pressure or vacuum condition inside the suit, and a pressure condition existing outside the suit; (d) a lift-assistance device connected to the suit for counteracting a downwards force applied to the suit when it is placed under the differential pressure condition, comprising a constant-force adjustment system that lifts the suit vertically as the mammal rises from the seated position to the standing position; (e) whereby the differential pressure condition exerts an upwards force upon the body part to offload a desired portion of the weight of the body to the lift-assistance device, whereupon the mammal may stand easily with reduced effort, and move about with body weight support. (a) a pressure-tight suit adapted to being worn over at least one part of the mammal's body having at least one opening for inserting the body part into the suit; (b) means for providing a pressure-tight seal connected adjacent to the opening of the suit for operative engagement of the body part surface of the mammal; (c) inlet means in the suit for introduction of at least one source of positive pressure or vacuum to an interior of the suit between the mammal body and the suit to create a differential pressure condition therein between the positive pressure or vacuum condition inside the suit, and a pressure condition existing outside the suit; (d) a lift-assistance device connected to the suit for counteracting a downwards force applied to the suit when it is placed under the differential pressure condition, comprising a constant-force adjustment system that lifts the suit vertically as the mammal rises from the seated position to the standing position; (e) whereby the differential pressure condition exerts an upwards force upon the body part to offload a desired portion of the weight of the body to the lift-assistance device, whereupon the mammal may stand easily with reduced effort, and move about with body weight support.
A purified biosurfactant comprising a hydrophobic lipid component comprising a carboxyl end and a hydroxyl end, wherein the lipid component is covalently linked to (i) a peptide or peptide-like chain at the carboxyl end of the lipid component and (ii) a carbohydrate moiety at the hydroxyl end of the lipid component via a glycosidic linkage, wherein the carbohydrate moiety includes one, two or three rhamnose moieties.
Embossing structure for an embossing roller for gluing tissue products, which has at least one embossing elevation with an embossing surface for creating an embossing motif, wherein a plurality of gluing elevations are arranged on the embossing elevation, which are raised relative to the embossing elevation and provide a smaller pressing surface relative to the embossing surface, wherein the embossing elevation is a linear web, characterized in that the embossing structure has at least two embossing elevations arranged in particular perpendicular to each other, which overlap at at least one intersection point.
A hernia repair prosthesis comprising: (a) a segmented frame having one or more first segments and one or more second segments together forming a closed loop where each first segment comprises a hollow tubular strand defining a lumen and each second segment comprises a strand with opposed end portions; and (b) a prosthetic fabric attached to the segmented frame characterised in that: opposed end portions of each second segment are contained within respective end portions (8, 10) of adjacent one or more first segments and slidable therein to enable the frame segments to move telescopically with respect to one another, and each first segment comprises a hollow tubular metal strand defining said lumen and each second segment comprises a metal strand. (a) a segmented frame having one or more first segments and one or more second segments together forming a closed loop where each first segment comprises a hollow tubular strand defining a lumen and each second segment comprises a strand with opposed end portions; and (b) a prosthetic fabric attached to the segmented frame characterised in that: opposed end portions of each second segment are contained within respective end portions (8, 10) of adjacent one or more first segments and slidable therein to enable the frame segments to move telescopically with respect to one another, and each first segment comprises a hollow tubular metal strand defining said lumen and each second segment comprises a metal strand. opposed end portions of each second segment are contained within respective end portions (8, 10) of adjacent one or more first segments and slidable therein to enable the frame segments to move telescopically with respect to one another, and each first segment comprises a hollow tubular metal strand defining said lumen and each second segment comprises a metal strand.
A holding jig (70, 270, 370) holding a pillar-like body, which has a tubular jig base member (50, 250, 350), and a tubular expansion/contraction member (52, 152) disposed on an inner peripheral surface side of the tubular jig base member, wherein both end sides of the tubular expansion/contraction member are fixed to both end sides of the tubular jig base member (50, 250, 350) along the whole periphery, a configuration of the inner peripheral surface of the tubular expansion/contraction member is smaller than a surface configuration of the pillar-like body to be held, and the configuration of the inner peripheral surface of the tubular jig base member is larger than the surface configuration of the pillar-like body to be held, and wherein the inner peripheral surface of the tubular jig base member is provided with a groove and a concave portion along the whole periphery to receive the expansion/contraction member, and the tubular expansion/contraction member is a rubber tube, characterized in that the tubular expansion/contraction member is always disposed away from the tubular jig base member in the groove.
A golf ball comprising a main body and a paint layer positioned outside the main body, wherein the golf ball has, on a surface thereof, a plurality of minute projections each having a shape in which a surface shape of the main body is reflected, the surface of the golf ball has an arithmetic average height Sa of not less than 0.5 μm and not greater than 30 μm, and an average value Hav of heights H of the minute projections is not less than 0.5 μm and not greater than 50 μm. the golf ball has, on a surface thereof, a plurality of minute projections each having a shape in which a surface shape of the main body is reflected, the surface of the golf ball has an arithmetic average height Sa of not less than 0.5 μm and not greater than 30 μm, and an average value Hav of heights H of the minute projections is not less than 0.5 μm and not greater than 50 μm.
A return channel system for an ultra-small aperture terminal, said terminal comprising a spreader configured to receive an input signal and to output a spread spectrum signal having multiple replicated signals with a power lower than the input signal, the system comprising: a de-multiplexer configured to receive a spread spectrum signal via a satellite channel, said de-multiplexer separating the spread spectrum signal into a first channel having a first signal and a second channel having a second signal; an offset compensation circuit having a sliding block phase estimator configured to determine a phase offset between a phase of the first signal and a phase of the second signal; a phase adjustor configured to adjust the phase of the second signal to align with the phase of the first signal based on the phase offset to provide a phase-adjusted second signal; and, a summer configured to combine the first signal with the phase-adjusted second signal. a de-multiplexer configured to receive a spread spectrum signal via a satellite channel, said de-multiplexer separating the spread spectrum signal into a first channel having a first signal and a second channel having a second signal; an offset compensation circuit having a sliding block phase estimator configured to determine a phase offset between a phase of the first signal and a phase of the second signal; a phase adjustor configured to adjust the phase of the second signal to align with the phase of the first signal based on the phase offset to provide a phase-adjusted second signal; and, a summer configured to combine the first signal with the phase-adjusted second signal.
A metal air battery, comprising: a negative electrode comprising one metal selected from a group consisting of Li, Zn, Mg, Al, and Fe; a positive electrode comprising a mixture of a carbon material and an oxygen-storing material which stores an oxygen-containing species; and an electrolyte interposed between the negative electrode and the positive electrode, characterized in that the oxygen-storing material has a hexagonal structure and comprises a composite oxide represented by the chemical formula YMnO 3. a negative electrode comprising one metal selected from a group consisting of Li, Zn, Mg, Al, and Fe; a positive electrode comprising a mixture of a carbon material and an oxygen-storing material which stores an oxygen-containing species; and an electrolyte interposed between the negative electrode and the positive electrode, characterized in that the oxygen-storing material has a hexagonal structure and comprises a composite oxide represented by the chemical formula YMnO 3.
An antenna for an RFID reading apparatus, the antenna having a plurality of single antennas of the inverted-F type, wherein the single antennas are arranged in a plane and are tilted with respect to one another within the plane, and having a feed circuit that is connected to the single antennas for controlling the single antennas with a mutual phase offset corresponding to the tilt in order to generate a circular polarization, wherein the antenna comprises at least four single antennas (10a-d), which are aligned in a direction of rotation, and a common ground plane (20, 28) in parallel with the plane, wherein the individual antennas (10a-d) are arranged on a circuit board in the plane, characterized in that openings are provided in the circuit board at least in an environment of the single antennas (10a-d) and in that the ground plane (20, 28) is formed by a wall of a conductive housing component on which the circuit board is seated with an overhang, with the single antennas (10a-d) being at least partly arranged on the overhang.
A manufacturing method of a microneedle array comprising: an adjustment step of positioning and adjusting a mold having a first surface and a second surface, which oppose each other, and a plurality of needle-like recessed portions in the first surface, and an ejection nozzle which ejects a drug solution in a first direction; a relative movement step of moving the mold and the ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the ejection nozzle to coincide with each other in a plan view in the first direction; an ejection step of ejecting the drug solution from the ejection nozzle toward the needle-like recessed portion; a vibration step of vibrating the mold to move the drug solution toward the needle-like recessed portion and close the needle-like recessed portion with the drug solution after the ejection step; and a suction step of suctioning the second surface of the mold. an adjustment step of positioning and adjusting a mold having a first surface and a second surface, which oppose each other, and a plurality of needle-like recessed portions in the first surface, and an ejection nozzle which ejects a drug solution in a first direction; a relative movement step of moving the mold and the ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the ejection nozzle to coincide with each other in a plan view in the first direction; an ejection step of ejecting the drug solution from the ejection nozzle toward the needle-like recessed portion; a vibration step of vibrating the mold to move the drug solution toward the needle-like recessed portion and close the needle-like recessed portion with the drug solution after the ejection step; and a suction step of suctioning the second surface of the mold.