A support mechanism for an open-roof assembly for use in a vehicle roof, the vehicle roof extending in a roof plane, the roof plane extending in a longitudinal direction and a width direction, the width direction being perpendicular to the longitudinal direction, wherein the open-roof assembly comprises a moveable panel for closing an opening in the vehicle roof, the support mechanism comprising: a) a panel support assembly, comprising i. a panel mounting portion; ii. a front support portion fixedly coupled to the panel mounting portion, comprising a front coupling portion; and iii. a rear support portion slideably coupled to the panel mounting portion, comprising a rear coupling portion; b) a guide assembly (6, 6a, 6b), comprising i. an elongated guide rail extending in the longitudinal direction; ii. a front mechanism slideably arranged in the guide rail and comprising a front hinge, the front coupling portion being coupled to the front hinge; iii. a rear mechanism arranged in the guide rail and comprising a rear hinge, the rear coupling portion being coupled to the rear hinge; wherein the front mechanism and the rear mechanism are provided with means for providing a relatively high mechanism stiffness; characterized in that the panel support assembly comprises at least one flexible portion selected from a front flexible portion and a rear flexible portion, wherein the front flexible portion is comprised in the front support portion and extends in a front main direction (C-C), the main direction extending from the front coupling portion to the panel mounting portion; wherein the rear flexible portion is comprised in the rear support portion and extends in a rear main direction (G-G), the rear main direction extending from the rear coupling portion to the panel mounting portion; and wherein the flexible portion is provided with a relatively low bending stiffness in the width direction and with a relatively low rotational stiffness in the respective main directions such that orientation deviations between the panel support assembly and the guide assembly result in larger rotational deformation in at least one of the respective flexible portions than in the respective mechanisms. a) a panel support assembly, comprising i. a panel mounting portion; ii. a front support portion fixedly coupled to the panel mounting portion, comprising a front coupling portion; and iii. a rear support portion slideably coupled to the panel mounting portion, comprising a rear coupling portion; i. a panel mounting portion; ii. a front support portion fixedly coupled to the panel mounting portion, comprising a front coupling portion; and iii. a rear support portion slideably coupled to the panel mounting portion, comprising a rear coupling portion; b) a guide assembly (6, 6a, 6b), comprising i. an elongated guide rail extending in the longitudinal direction; ii. a front mechanism slideably arranged in the guide rail and comprising a front hinge, the front coupling portion being coupled to the front hinge; iii. a rear mechanism arranged in the guide rail and comprising a rear hinge, the rear coupling portion being coupled to the rear hinge; i. an elongated guide rail extending in the longitudinal direction; ii. a front mechanism slideably arranged in the guide rail and comprising a front hinge, the front coupling portion being coupled to the front hinge; iii. a rear mechanism arranged in the guide rail and comprising a rear hinge, the rear coupling portion being coupled to the rear hinge; characterized in that the panel support assembly comprises at least one flexible portion selected from a front flexible portion and a rear flexible portion, wherein the front flexible portion is comprised in the front support portion and extends in a front main direction (C-C), the main direction extending from the front coupling portion to the panel mounting portion; wherein the rear flexible portion is comprised in the rear support portion and extends in a rear main direction (G-G), the rear main direction extending from the rear coupling portion to the panel mounting portion; and wherein the flexible portion is provided with a relatively low bending stiffness in the width direction and with a relatively low rotational stiffness in the respective main directions such that orientation deviations between the panel support assembly and the guide assembly result in larger rotational deformation in at least one of the respective flexible portions than in the respective mechanisms.