A computed tomography imaging process, including: accessing projection data representing two-dimensional projection images of an object acquired using a misaligned tomographic imaging apparatus having a cone beam geometry, the projection images being acquired along a scanning trajectory involving linear translation of the object and rotation of the object about a rotation axis, translating and rotating the object by small amounts between the acquisition of successive ones of the projection images; and processing the projection data to generate misalignment data representing one or more misalignment values that quantify respective misalignments of the tomographic imaging apparatus; wherein said processing includes: processing the projection data to generate trial reconstructed tomographic cross-sectional images for respective trial values of at least one misalignment of the tomographic imaging apparatus, at least one of said trial reconstructed tomographic cross-sectional images being non-orthogonal to the rotation axis; processing the trial reconstructed tomographic images to generate respective evaluations of quality of the trial reconstructed tomographic images; and for each said at least one misalignment of the tomographic imaging apparatus, determining a corresponding misalignment value that best estimates the misalignment, based on the trial values and the corresponding evaluations of quality. accessing projection data representing two-dimensional projection images of an object acquired using a misaligned tomographic imaging apparatus having a cone beam geometry, the projection images being acquired along a scanning trajectory involving linear translation of the object and rotation of the object about a rotation axis, translating and rotating the object by small amounts between the acquisition of successive ones of the projection images; and processing the projection data to generate misalignment data representing one or more misalignment values that quantify respective misalignments of the tomographic imaging apparatus; wherein said processing includes: processing the projection data to generate trial reconstructed tomographic cross-sectional images for respective trial values of at least one misalignment of the tomographic imaging apparatus, at least one of said trial reconstructed tomographic cross-sectional images being non-orthogonal to the rotation axis; processing the trial reconstructed tomographic images to generate respective evaluations of quality of the trial reconstructed tomographic images; and for each said at least one misalignment of the tomographic imaging apparatus, determining a corresponding misalignment value that best estimates the misalignment, based on the trial values and the corresponding evaluations of quality. processing the projection data to generate misalignment data representing one or more misalignment values that quantify respective misalignments of the tomographic imaging apparatus; wherein said processing includes: processing the projection data to generate trial reconstructed tomographic cross-sectional images for respective trial values of at least one misalignment of the tomographic imaging apparatus, at least one of said trial reconstructed tomographic cross-sectional images being non-orthogonal to the rotation axis; processing the trial reconstructed tomographic images to generate respective evaluations of quality of the trial reconstructed tomographic images; and for each said at least one misalignment of the tomographic imaging apparatus, determining a corresponding misalignment value that best estimates the misalignment, based on the trial values and the corresponding evaluations of quality. processing the projection data to generate trial reconstructed tomographic cross-sectional images for respective trial values of at least one misalignment of the tomographic imaging apparatus, at least one of said trial reconstructed tomographic cross-sectional images being non-orthogonal to the rotation axis; processing the trial reconstructed tomographic images to generate respective evaluations of quality of the trial reconstructed tomographic images; and for each said at least one misalignment of the tomographic imaging apparatus, determining a corresponding misalignment value that best estimates the misalignment, based on the trial values and the corresponding evaluations of quality.