An intradermal injection assembly for injecting a medicament into a dermal skin layer, the assembly comprising: a syringe including a cannula,, with a tip, a hub, a barrel and a plunger, the barrel having a generally cylindrical configuration and a hollow internal cavity adapted to receive the medicament therein; and an adapter having a body with a syringe channel, a central portion with a cannula channel defining a cannula channel edge, a distal protrusion with a distal nose, the distal protrusion including a generally continuous first skin contacting surface, a proximal end portion and a longitudinal axis extending between the proximal end portion and the distal nose, wherein the generally continuous first skin contacting surface is positioned generally parallel to the longitudinal axis, a distal portion of the cannula being spaced from the first skin contacting surface at a cannula, gap distance in the assembled configuration, the tip of the cannula being positioned distally relative to the cannula, channel edge in an assembled configuration, wherein a side opening extending along an entire length of the adapter generally parallel to the longitudinal axis, the opening permitting selective insertion and removal of the syringe therein, characterized in that the adapter comprises an alignment ramp positioned within the cannula, channel, wherein the alignment ramp orients a distal portion of the cannula generally parallel with the first skin contacting surface in the assembled configuration to control spacing of the cannula, relative to the first skin contacting surface such that the tip of the cannula is configured for positioning in the dermal skin layer when the intradermal injection assembly is in an injection position. a syringe including a cannula,, with a tip, a hub, a barrel and a plunger, the barrel having a generally cylindrical configuration and a hollow internal cavity adapted to receive the medicament therein; and an adapter having a body with a syringe channel, a central portion with a cannula channel defining a cannula channel edge, a distal protrusion with a distal nose, the distal protrusion including a generally continuous first skin contacting surface, a proximal end portion and a longitudinal axis extending between the proximal end portion and the distal nose, wherein the generally continuous first skin contacting surface is positioned generally parallel to the longitudinal axis, a distal portion of the cannula being spaced from the first skin contacting surface at a cannula, gap distance in the assembled configuration, the tip of the cannula being positioned distally relative to the cannula, channel edge in an assembled configuration, wherein a side opening extending along an entire length of the adapter generally parallel to the longitudinal axis, the opening permitting selective insertion and removal of the syringe therein, characterized in that the adapter comprises an alignment ramp positioned within the cannula, channel, wherein the alignment ramp orients a distal portion of the cannula generally parallel with the first skin contacting surface in the assembled configuration to control spacing of the cannula, relative to the first skin contacting surface such that the tip of the cannula is configured for positioning in the dermal skin layer when the intradermal injection assembly is in an injection position.