A compound of formula: or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof,wherein: the A-B bicyclic ring is optionally substituted with one or more groups independently selected from deuterium, -NH 2,, -OH, alkyl(C 1 -C 6), thioalkyl(C 1 -C 6), and alkoxy(C 1 -C 6); D 1 is an isoxazole or pyrazole optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, -CF 3, CN, -OCF 3,-N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4),-SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with F, Cl, Br, -OH, -NH 2,-NHMe, -NMe 2, -OMe, -SMe, oxo, and/or thio-oxo; X is optionally present, and if present, is selected from - -, -NHCR x R y -, -NHSO 2 -,-CR x R y NH-, or -NH 2 and R 3 is absent; R 3 is selected from isoxazolyl, oxazolyl, pyrazolyl, pyridyl, pyridonyl, thiazolyl, isothiazolyl, pyrimidinyl, thiozolyl, pyrazinyl, pyridazinyl, azetidinyl, pyrrolidyl, piperidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and phenyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, -CF 3, CN, -OCF 3, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4),-SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with F, Cl, Br, -OH, -NH 2,-NHMe, -NMe 2, -OMe, -SMe, oxo, and/or thio-oxo. D 1 is an isoxazole or pyrazole optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, -CF 3, CN, -OCF 3,-N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4),-SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with F, Cl, Br, -OH, -NH 2,-NHMe, -NMe 2, -OMe, -SMe, oxo, and/or thio-oxo; X is optionally present, and if present, is selected from - -, -NHCR x R y -, -NHSO 2 -,-CR x R y NH-, or -NH 2 and R 3 is absent; R 3 is selected from isoxazolyl, oxazolyl, pyrazolyl, pyridyl, pyridonyl, thiazolyl, isothiazolyl, pyrimidinyl, thiozolyl, pyrazinyl, pyridazinyl, azetidinyl, pyrrolidyl, piperidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and phenyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, -CF 3, CN, -OCF 3, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4),-SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with F, Cl, Br, -OH, -NH 2,-NHMe, -NMe 2, -OMe, -SMe, oxo, and/or thio-oxo.