A medical device comprising a lubricating coating directly on its surface or on an optional adhesion layer arranged on the surface of the medical device for use in wet and/or dry conditions, wherein the lubricating coating comprises i. at least one polymer A selected from the group consisting of polyvinylpyrrolidone, linear or branched polyethyleneglycol, dextran, polyalkyloxazolines (PAOXA), poly(2-methyl-2-oxazoline) (PMOXA), poly(ethyl-oxazoline) (PEOXA), hyaluronic acid, polyvinylalcohol, poly(2-hydroxyethyl methacrylate) (pHEMA), poly(1-vinylpyrrolidone-co-styrene), poly(1-vinylpyrrolidone)-graft-(1-triacontene), poly(1-vinylpyrrolidone-co-vinyl acetate), poly(ethylene-co-vinyl alcohol), poly(ethylene-co-vinylpyrrolidone), poly(maleic acid), poly(ethylene-co-maleic acid), polyacrylic acid, poly(acrylamide), poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA), poly(N-isopropylacrylamide)(PNIPAM), poly[(organo)phosphazenes], chitosan, xantham gum, starch, pectin, algin, agarose, cellulose, cellulose esters, cellulose ethers, hydroxypropylmethyl cellulose (HPMC) and hydroxyethyl cellulose or a mixture thereof, ii. at least one cross-linker comprising a core and at least two reactive groups, wherein the core is selected from the group consisting of polyallylamine (PAAm), polyethylene glycol, polyvinylpyrrolidone, polyethyleneimine, polylysine, polyacrylic acid, polyvinylalcohol, polyaspartic acid, dextran, chitin, chitosan, agarose, albumin, in particular bovine serum albumin, fibronectin, fibrinogen, keratin, collagen, lysozyme and multivalent molecules having less than 20 carbon atoms and the reactive groups are each independently selected from the group consisting of and and mixtures thereof, wherein R 1, R 2, R 3 and R 4 are, independently from one another, H, F or Cl; and R 5 and R 5 ' is independently methyl, ethyl, propyl, isopropyl or dimethylamine and n is 0 to 4 and R 6 and R 6 ' is independently methyl, ethyl, propyl, isopropyl or dimethylamine and m is 0 to 4 and the core is linked to the reactive group by a linker group B selected from the group consisting of a secondary or tertiary amine, an ether, a thioether, a carboxylic acid ester, an amide and a thioester, iii. at least one lubricant, and wherein a portion of the at least two reactive groups of the cross-linker are covalently linked to the polymer A to form a three-dimensional network in which the lubricant is incorporated, and wherein at the same time another portion of the reactive groups of the cross-linker are covalently linked to the surface of the medical device or to the optional adhesion layer on the surface of the medical device. i. at least one polymer A selected from the group consisting of polyvinylpyrrolidone, linear or branched polyethyleneglycol, dextran, polyalkyloxazolines (PAOXA), poly(2-methyl-2-oxazoline) (PMOXA), poly(ethyl-oxazoline) (PEOXA), hyaluronic acid, polyvinylalcohol, poly(2-hydroxyethyl methacrylate) (pHEMA), poly(1-vinylpyrrolidone-co-styrene), poly(1-vinylpyrrolidone)-graft-(1-triacontene), poly(1-vinylpyrrolidone-co-vinyl acetate), poly(ethylene-co-vinyl alcohol), poly(ethylene-co-vinylpyrrolidone), poly(maleic acid), poly(ethylene-co-maleic acid), polyacrylic acid, poly(acrylamide), poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA), poly(N-isopropylacrylamide)(PNIPAM), poly[(organo)phosphazenes], chitosan, xantham gum, starch, pectin, algin, agarose, cellulose, cellulose esters, cellulose ethers, hydroxypropylmethyl cellulose (HPMC) and hydroxyethyl cellulose or a mixture thereof, ii. at least one cross-linker comprising a core and at least two reactive groups, wherein the core is selected from the group consisting of polyallylamine (PAAm), polyethylene glycol, polyvinylpyrrolidone, polyethyleneimine, polylysine, polyacrylic acid, polyvinylalcohol, polyaspartic acid, dextran, chitin, chitosan, agarose, albumin, in particular bovine serum albumin, fibronectin, fibrinogen, keratin, collagen, lysozyme and multivalent molecules having less than 20 carbon atoms and the reactive groups are each independently selected from the group consisting of and and mixtures thereof, wherein R 1, R 2, R 3 and R 4 are, independently from one another, H, F or Cl; and R 5 and R 5 ' is independently methyl, ethyl, propyl, isopropyl or dimethylamine and n is 0 to 4 and R 6 and R 6 ' is independently methyl, ethyl, propyl, isopropyl or dimethylamine and m is 0 to 4 and the core is linked to the reactive group by a linker group B selected from the group consisting of a secondary or tertiary amine, an ether, a thioether, a carboxylic acid ester, an amide and a thioester, iii. at least one lubricant, and wherein a portion of the at least two reactive groups of the cross-linker are covalently linked to the polymer A to form a three-dimensional network in which the lubricant is incorporated, and wherein at the same time another portion of the reactive groups of the cross-linker are covalently linked to the surface of the medical device or to the optional adhesion layer on the surface of the medical device.