A bone and tissue resection device, comprising: a blade having a distal cutting edge configured to perform a cutting action that produces a plug or core from a media being cut by the cutting edge; a drive mechanism arranged to transfer an oscillating force to the cutting edge for oscillating the cutting edge about a proximal-distal axis of the cutting edge, the drive mechanism comprising: an input shaft configured to continuously rotate about a first central axis, a portion of a length of the input shaft defining an eccentric section, the eccentric section defining a second central axis that is offset from the first central axis, a linkage disposed around the eccentric section at a first end thereof and having a second end, and an oscillating shaft defining a central axis thereof, the oscillating shaft coupled to the second end of the linkage at a fixed location offset from the central axis of the oscillating shaft, wherein continuous rotation of the input shaft about the first central axis creates an oscillating movement of the second end around the central axis of the oscillating shaft with oscillating rotational movement of the oscillating shaft about the central axis of the oscillating shaft; a shield positioned to block contact with a portion of the cutting edge; and a depth adjustment mechanism (1901, 2001, 2102, 2201) configured to translate the cutting edge along a proximal-distal axis of the shield to adjust an axial position of the cutting edge relative to the shield. a blade having a distal cutting edge configured to perform a cutting action that produces a plug or core from a media being cut by the cutting edge; a drive mechanism arranged to transfer an oscillating force to the cutting edge for oscillating the cutting edge about a proximal-distal axis of the cutting edge, the drive mechanism comprising: an input shaft configured to continuously rotate about a first central axis, a portion of a length of the input shaft defining an eccentric section, the eccentric section defining a second central axis that is offset from the first central axis, a linkage disposed around the eccentric section at a first end thereof and having a second end, and an oscillating shaft defining a central axis thereof, the oscillating shaft coupled to the second end of the linkage at a fixed location offset from the central axis of the oscillating shaft, wherein continuous rotation of the input shaft about the first central axis creates an oscillating movement of the second end around the central axis of the oscillating shaft with oscillating rotational movement of the oscillating shaft about the central axis of the oscillating shaft; an input shaft configured to continuously rotate about a first central axis, a portion of a length of the input shaft defining an eccentric section, the eccentric section defining a second central axis that is offset from the first central axis, a linkage disposed around the eccentric section at a first end thereof and having a second end, and an oscillating shaft defining a central axis thereof, the oscillating shaft coupled to the second end of the linkage at a fixed location offset from the central axis of the oscillating shaft, wherein continuous rotation of the input shaft about the first central axis creates an oscillating movement of the second end around the central axis of the oscillating shaft with oscillating rotational movement of the oscillating shaft about the central axis of the oscillating shaft; a shield positioned to block contact with a portion of the cutting edge; and a depth adjustment mechanism (1901, 2001, 2102, 2201) configured to translate the cutting edge along a proximal-distal axis of the shield to adjust an axial position of the cutting edge relative to the shield.