A polypeptide comprising a variant of a starting amino acid sequence, wherein the starting amino acid sequence is amino acids 1-217 of SEQ ID NO:1, wherein: (a) the polypeptide binds to and/or disaggregates amyloid; (b) the polypeptide has reduced immunogenicity as compared to a polypeptide comprising the starting amino acid sequence; (c) the variant has from 1 to 9 amino acid substitutions as compared to the starting amino acid sequence, wherein each amino acid substitution is selected from the group of amino acid substitutions set forth below: Amino Acid # Amino Acid present in the Starting Amino Acid Sequence Amino Acid Substitutions in the Variant 48 G H, K, R, S, T, D, P 50 E G, H, K, P, R 51 T G, H, K, R, P, Q, N, W 53 C F, H, K, N, Q, R, W, Y 54 Y G, H, K, R, P 56 T G, H, K, R, P 135 M A, D, G, K, N, T, H, R, C, E, P, Q, S 137 Q D, E 138 N D, E, G, H, P, Q, S, T 140 R D, E, H, Q, A, G, M, N, P, S, Y 141 F D, E, G, N, P, Q, Y 143 N A, G 173 S G, P, K, D, H, R, T 174 K R 175 A G, H, K, P, R 176 M G, H, K, N, R, P, Q, W 178 D G, N, Q, S, T, F, H, K, R, W, Y 179 A H,K,P,R 181 W G, H, K, R, P 215 V S, T, C, D, E, F, H, K, N, P, Q, R and (d) the variant optionally further comprises one or more of the following modifications as compared to the starting amino acid sequence: (i) substitution of VVV at amino acids 43-45 with AAA; (ii) substitution C53W; (iii) deletion of amino acids 96-103; (iv) substitution of QPP at amino acids 212-214 with AGA; (v) substitutions W181A, F190A and F194A; (vi) deletion of amino acid 1; and (vii) deletion of amino acids 1 and 2. (a) the polypeptide binds to and/or disaggregates amyloid; (b) the polypeptide has reduced immunogenicity as compared to a polypeptide comprising the starting amino acid sequence; (c) the variant has from 1 to 9 amino acid substitutions as compared to the starting amino acid sequence, wherein each amino acid substitution is selected from the group of amino acid substitutions set forth below: Amino Acid # Amino Acid present in the Starting Amino Acid Sequence Amino Acid Substitutions in the Variant 48 G H, K, R, S, T, D, P 50 E G, H, K, P, R 51 T G, H, K, R, P, Q, N, W 53 C F, H, K, N, Q, R, W, Y 54 Y G, H, K, R, P 56 T G, H, K, R, P 135 M A, D, G, K, N, T, H, R, C, E, P, Q, S 137 Q D, E 138 N D, E, G, H, P, Q, S, T 140 R D, E, H, Q, A, G, M, N, P, S, Y 141 F D, E, G, N, P, Q, Y 143 N A, G 173 S G, P, K, D, H, R, T 174 K R 175 A G, H, K, P, R 176 M G, H, K, N, R, P, Q, W 178 D G, N, Q, S, T, F, H, K, R, W, Y 179 A H,K,P,R 181 W G, H, K, R, P 215 V S, T, C, D, E, F, H, K, N, P, Q, R and (d) the variant optionally further comprises one or more of the following modifications as compared to the starting amino acid sequence: (i) substitution of VVV at amino acids 43-45 with AAA; (ii) substitution C53W; (iii) deletion of amino acids 96-103; (iv) substitution of QPP at amino acids 212-214 with AGA; (v) substitutions W181A, F190A and F194A; (vi) deletion of amino acid 1; and (vii) deletion of amino acids 1 and 2. (i) substitution of VVV at amino acids 43-45 with AAA; (ii) substitution C53W; (iii) deletion of amino acids 96-103; (iv) substitution of QPP at amino acids 212-214 with AGA; (v) substitutions W181A, F190A and F194A; (vi) deletion of amino acid 1; and (vii) deletion of amino acids 1 and 2.