A method, comprising: segmenting a region of interest in imaging data in a visual presentation of the imaging data, wherein the segmenting is performed by a computer-implemented segmentor; and visually highlighting, concurrently with the segmenting, a portion of the region of interest while the region of interest is being segmented using the segmentor as the segmentor identifies voxels which will be highlighted, wherein the visual highlighting includes coloring the portion of the region of interest while the region of interest is being segmented; characterized by removing highlighting responsive to user selection from a previously highlighted region of the visual presentation, wherein removing the highlighting includes identifying a segment of the highlighted segmentation and removing the highlighting from the segment; wherein removing the highlighting from the segment comprises identifying a color overlay for the identified segment and removing said overlay; wherein the region of interest is a vessel, and the segmenting the region of interest, further comprising: tracking along the vessel; and determining a cross section of the vessel; and segmenting a lumen of the vessel based on an imaging characteristic of the lumen and segmenting one or more of an outer wall, a calcification, a wall thickness, or plaque of the vessel respectively based on an imaging characteristic of the outer wall, the calcification, the wall thickness, or the plaque; and the visually highlighting comprising visually highlighting one or more of the segmented outer wall, calcification, wall thickness, or plaque. segmenting a region of interest in imaging data in a visual presentation of the imaging data, wherein the segmenting is performed by a computer-implemented segmentor; and visually highlighting, concurrently with the segmenting, a portion of the region of interest while the region of interest is being segmented using the segmentor as the segmentor identifies voxels which will be highlighted, wherein the visual highlighting includes coloring the portion of the region of interest while the region of interest is being segmented; characterized by removing highlighting responsive to user selection from a previously highlighted region of the visual presentation, wherein removing the highlighting includes identifying a segment of the highlighted segmentation and removing the highlighting from the segment; wherein removing the highlighting from the segment comprises identifying a color overlay for the identified segment and removing said overlay; wherein the region of interest is a vessel, and the segmenting the region of interest, further comprising: tracking along the vessel; and determining a cross section of the vessel; and segmenting a lumen of the vessel based on an imaging characteristic of the lumen and segmenting one or more of an outer wall, a calcification, a wall thickness, or plaque of the vessel respectively based on an imaging characteristic of the outer wall, the calcification, the wall thickness, or the plaque; and the visually highlighting comprising visually highlighting one or more of the segmented outer wall, calcification, wall thickness, or plaque. tracking along the vessel; and determining a cross section of the vessel; and segmenting a lumen of the vessel based on an imaging characteristic of the lumen and segmenting one or more of an outer wall, a calcification, a wall thickness, or plaque of the vessel respectively based on an imaging characteristic of the outer wall, the calcification, the wall thickness, or the plaque; and the visually highlighting comprising visually highlighting one or more of the segmented outer wall, calcification, wall thickness, or plaque.