A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature Tb and for stabilizing said body temperature at said target temperature Tb, said system comprising: - a cabinet, in which the individual is located, said cabinet being provided with isolation and heating for heating the air of the cabinet, for maintaining an individual at an elevated temperature, - at least one thermal means, configured to raise said body temperature at a rate of at least 1 °C/hour, and subsequently set to obtain and maintain the target temperature Tb of said individual, ∘ wherein said at least one thermal means comprises a first thermal means for raising said body temperature at a rate of at least 1 °C/hour, ∘ wherein raising said body temperature by said first thermal means is not performed by external heating of the blood system by means of a heat-exchanger, external to the body, for heating blood removed from the body and subsequently returned to the body, and ∘ wherein said first thermal means do not comprise an internally heated fluid circuit comprising a catheter wherein a heating fluid heated outside of the body in a heat exchanger is circulated, - one or more devices to prevent or counter heat loss from the individual, said one or more devices being devices for heating air and/or oxygen for respiration, or devices for heating liquids being introduced in the body, - one or more sensors monitoring the temperature or heat flux of the individual, connected to controllers steering said devices to prevent or counter heat loss and steering the at least one thermal means, wherein said first thermal means has at least a first portion and at least a second portion, wherein the at least first portion of the first thermal means is arranged to raise the body temperature of at least a first series of body parts of the individual to the target temperature T b, and wherein the at least second portion of the first thermal means is arranged to prevent at least a second series of body parts to exceed a target temperature T s, wherein the temperature T s is lower than the temperature T b, wherein said second portion further includes means for cooling individual organs, wherein said means for cooling individual organs are applied to the brain and at least one of the liver, the kidneys and the colon, and wherein said one or more devices to prevent or counter heat loss comprises means for bringing the individual under anaesthesia, said means being provided to be supplied to the individual at a temperature Tb. - a cabinet, in which the individual is located, said cabinet being provided with isolation and heating for heating the air of the cabinet, for maintaining an individual at an elevated temperature, - at least one thermal means, configured to raise said body temperature at a rate of at least 1 °C/hour, and subsequently set to obtain and maintain the target temperature Tb of said individual, ∘ wherein said at least one thermal means comprises a first thermal means for raising said body temperature at a rate of at least 1 °C/hour, ∘ wherein raising said body temperature by said first thermal means is not performed by external heating of the blood system by means of a heat-exchanger, external to the body, for heating blood removed from the body and subsequently returned to the body, and ∘ wherein said first thermal means do not comprise an internally heated fluid circuit comprising a catheter wherein a heating fluid heated outside of the body in a heat exchanger is circulated, ∘ wherein said at least one thermal means comprises a first thermal means for raising said body temperature at a rate of at least 1 °C/hour, ∘ wherein raising said body temperature by said first thermal means is not performed by external heating of the blood system by means of a heat-exchanger, external to the body, for heating blood removed from the body and subsequently returned to the body, and ∘ wherein said first thermal means do not comprise an internally heated fluid circuit comprising a catheter wherein a heating fluid heated outside of the body in a heat exchanger is circulated, - one or more devices to prevent or counter heat loss from the individual, said one or more devices being devices for heating air and/or oxygen for respiration, or devices for heating liquids being introduced in the body, - one or more sensors monitoring the temperature or heat flux of the individual, connected to controllers steering said devices to prevent or counter heat loss and steering the at least one thermal means, wherein said first thermal means has at least a first portion and at least a second portion, wherein the at least first portion of the first thermal means is arranged to raise the body temperature of at least a first series of body parts of the individual to the target temperature T b, and wherein the at least second portion of the first thermal means is arranged to prevent at least a second series of body parts to exceed a target temperature T s, wherein the temperature T s is lower than the temperature T b, wherein said second portion further includes means for cooling individual organs, wherein said means for cooling individual organs are applied to the brain and at least one of the liver, the kidneys and the colon, and wherein said one or more devices to prevent or counter heat loss comprises means for bringing the individual under anaesthesia, said means being provided to be supplied to the individual at a temperature Tb.