A compound of the general formula I wherein represents wherein R 1 is selected from methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, benzyloxy, OC OCH 2 CH 3, OCF 3, SCH 3, S 2 CH 3, OC OR 5, OC R 5, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, Cl, Br, I, CN, and phenyl; R 2 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3,NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Cl, Br, I, CN, and phenyl; R 3 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Cl, Br, I, CN, and phenyl; R 4 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Br, I, CN, and phenyl; R 5 represents C 1 -C 15 alkyl or phenyl; R 7, R 8, R 9, and R 10 are independently selected from hydrogen and methyl; or being selected such that R 8 and R 9 are connected to form a 5-, or 6-membered ring; and X is selected from hydrogen, C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 fluoroalkyl, phenyl, 2-phenylethyl, benzyl, C OCH 2 CH 3, and hydroxy; wherein said phenyl, 2-phenylethyl, and benzyl are optionally mono- or di-substituted by substituents independently selected from methyl, ethyl, methoxy, F, and Cl; and pharmaceutically acceptable salts, and stereoisomers thereof, with the proviso that when R 7 is methyl and having the configuration as shown in formula Ib, R 3 is not hydrogen; and when X, R 3, R 7 and R 8 are simultaneously hydrogen, R 1 is not methoxy. R 1 is selected from methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, benzyloxy, OC OCH 2 CH 3, OCF 3, SCH 3, S 2 CH 3, OC OR 5, OC R 5, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, Cl, Br, I, CN, and phenyl; R 2 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3,NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Cl, Br, I, CN, and phenyl; R 3 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Cl, Br, I, CN, and phenyl; R 4 is selected from hydrogen, methyl, ethyl, iso-propyl, cyclopropyl, CF 3, hydroxy, methoxy, ethoxy, iso-propoxy, OCF 3, SCH 3, S 2 CH 3, NH 2, NHCH 3, N(CH 3) 2, NHC H, NHC CH 3, NHC NH 2, NHC NHCH 3, NHC N(CH 3) 2, C CH 3, C N(CH 3) 2, F, Br, I, CN, and phenyl; R 5 represents C 1 -C 15 alkyl or phenyl; R 7, R 8, R 9, and R 10 are independently selected from hydrogen and methyl; or being selected such that R 8 and R 9 are connected to form a 5-, or 6-membered ring; and X is selected from hydrogen, C 1 -C 12 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 fluoroalkyl, phenyl, 2-phenylethyl, benzyl, C OCH 2 CH 3, and hydroxy; wherein said phenyl, 2-phenylethyl, and benzyl are optionally mono- or di-substituted by substituents independently selected from methyl, ethyl, methoxy, F, and Cl; and pharmaceutically acceptable salts, and stereoisomers thereof, with the proviso that when R 7 is methyl and having the configuration as shown in formula Ib, R 3 is not hydrogen; and when X, R 3, R 7 and R 8 are simultaneously hydrogen, R 1 is not methoxy.