mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising: (a) an effector cell displaying on its surface (i) a T cell receptor and (ii) an immune checkpoint receptor comprising an immune inhibitory receptor selected from the group consisting of: PD-1, CTLA-4, LAG-3, TIM-3, TIGIT, CD160, BTLA, and IL-10 receptor, wherein the effector cell comprises a gene encoding a fluorescent or bioluminescent reporter protein, the expression of which is under control of a nuclear factor of activated T-cells (NFAT) promoter, wherein the NFAT promoter comprises one or more NFAT response elements having at least 50% sequence identity to SEQ ID NO:1, and wherein the NFAT response elements bind to an NFAT family transcription factor to enhance transcription of associated genes; and (b) an antigen presenting cell displaying on its surface: (i) a T cell receptor activator and (ii) an immune checkpoint ligand selected from the group consisting of PD-L1, PD-L2, B7-H4, CD155, galectin-9, and HVEM, wherein the TCR activator is an anti-cluster-of-differentiation-3 antibody; wherein the ICR and ICL form an ICR/ICL complex upon interaction, and wherein formation of the ICR/ICL complex results in altered expression of the fluorescent or bioluminescent reporter protein. (a) an effector cell displaying on its surface (i) a T cell receptor and (ii) an immune checkpoint receptor comprising an immune inhibitory receptor selected from the group consisting of: PD-1, CTLA-4, LAG-3, TIM-3, TIGIT, CD160, BTLA, and IL-10 receptor, wherein the effector cell comprises a gene encoding a fluorescent or bioluminescent reporter protein, the expression of which is under control of a nuclear factor of activated T-cells (NFAT) promoter, wherein the NFAT promoter comprises one or more NFAT response elements having at least 50% sequence identity to SEQ ID NO:1, and wherein the NFAT response elements bind to an NFAT family transcription factor to enhance transcription of associated genes; and (b) an antigen presenting cell displaying on its surface: (i) a T cell receptor activator and (ii) an immune checkpoint ligand selected from the group consisting of PD-L1, PD-L2, B7-H4, CD155, galectin-9, and HVEM, wherein the TCR activator is an anti-cluster-of-differentiation-3 antibody; wherein the ICR and ICL form an ICR/ICL complex upon interaction, and wherein formation of the ICR/ICL complex results in altered expression of the fluorescent or bioluminescent reporter protein.
A wind energy installation comprising: a rotor with a first rotor blade which can be adjusted in terms of its angle, a first adjustment drive for adjusting the first rotor blade, and a first reversing device for supplying energy to the first adjustment drive from a source of energy via the first reversing device in order to adjust the first rotor blade in a first direction and for supplying energy to the first adjustment drive from the source of energy via the first reversing device in order to adjust the first rotor blade in a second direction which is opposite to the first direction; characterised by a safety control device / system; and a second reversing device, which can be switched over by means of the safety control device / system, for supplying energy to the first adjustment drive from an energy storage device in a first special mode of operation via the second reversing device in a first switching position in order to adjust the first rotor blade in the first direction and for supplying energy to the first adjustment drive from the energy storage device in the first special mode of operation via the second reversing device in a second switching position in order to adjust the first rotor blade in the second direction. a rotor with a first rotor blade which can be adjusted in terms of its angle, a first adjustment drive for adjusting the first rotor blade, and a first reversing device for supplying energy to the first adjustment drive from a source of energy via the first reversing device in order to adjust the first rotor blade in a first direction and for supplying energy to the first adjustment drive from the source of energy via the first reversing device in order to adjust the first rotor blade in a second direction which is opposite to the first direction; characterised by a safety control device / system; and a second reversing device, which can be switched over by means of the safety control device / system, for supplying energy to the first adjustment drive from an energy storage device in a first special mode of operation via the second reversing device in a first switching position in order to adjust the first rotor blade in the first direction and for supplying energy to the first adjustment drive from the energy storage device in the first special mode of operation via the second reversing device in a second switching position in order to adjust the first rotor blade in the second direction.
A molten metal temperature control method comprising: with respect to relations among a spheroidization distance (Lc) traveled by a molten metal of an alloy discharged from a nozzle, with a predetermined diameter (φ), of a crucible from a nozzle tip to a position where the molten metal turns into droplets, a temperature of the molten metal inside the crucible, and a pressure acting on the molten metal inside the crucible, obtaining in advance a relation between the temperature and the spheroidization distance (Lc) at a predetermined pressure that is the pressure acting on the molten metal inside the crucible in the form of a temperature-versus-spheroidization distance correlation as set for the predetermined pressure, and setting a predetermined temperature range (Ta to Tb) of the temperature in which a quenched ribbon of desired quality is produced; measuring the spheroidization distance (Lc) when discharging the molten metal from the crucible at the predetermined pressure, and specifying the temperature (Tc) corresponding to the measured spheroidization distance (Lc); and comparing the specified temperature (Tc) and the predetermined temperature range (Ta to Tb), and when the specified temperature (Tc) is outside the predetermined temperature range (Ta to Tb), controlling the specified temperature (Tc) so as to be within the predetermined temperature range (Ta to Tb) by adjusting the temperature inside the crucible. with respect to relations among a spheroidization distance (Lc) traveled by a molten metal of an alloy discharged from a nozzle, with a predetermined diameter (φ), of a crucible from a nozzle tip to a position where the molten metal turns into droplets, a temperature of the molten metal inside the crucible, and a pressure acting on the molten metal inside the crucible, obtaining in advance a relation between the temperature and the spheroidization distance (Lc) at a predetermined pressure that is the pressure acting on the molten metal inside the crucible in the form of a temperature-versus-spheroidization distance correlation as set for the predetermined pressure, and setting a predetermined temperature range (Ta to Tb) of the temperature in which a quenched ribbon of desired quality is produced; measuring the spheroidization distance (Lc) when discharging the molten metal from the crucible at the predetermined pressure, and specifying the temperature (Tc) corresponding to the measured spheroidization distance (Lc); and comparing the specified temperature (Tc) and the predetermined temperature range (Ta to Tb), and when the specified temperature (Tc) is outside the predetermined temperature range (Ta to Tb), controlling the specified temperature (Tc) so as to be within the predetermined temperature range (Ta to Tb) by adjusting the temperature inside the crucible.
Construction machine with a support apparatus and a processing device for creating a hole in the ground and an arrangement for data transmission from or into the hole in the ground, in particular a borehole or a cut trench, wherein arranged along the hole is the processing device, which is formed with an electrically conductive body and extends with an upper section out of the hole, Wherein - a first transmitting and/or receiving unit is arranged in the hole, - a second transmitting and/or receiving unit is arranged outside the hole and - the upper section of the processing device is configured as an antenna for emitting or respectively receiving a high-frequency signal, - the second transmitting and/or receiving unit is arranged outside the hole at a distance from the upper section on the support apparatus and - the transmitting and/or receiving units (30, 40) are configured to transmit or respectively receive the high-frequency signal, which is transmitted by the electrically conductive body of the processing device. - a first transmitting and/or receiving unit is arranged in the hole, - a second transmitting and/or receiving unit is arranged outside the hole and - the upper section of the processing device is configured as an antenna for emitting or respectively receiving a high-frequency signal, - the second transmitting and/or receiving unit is arranged outside the hole at a distance from the upper section on the support apparatus and - the transmitting and/or receiving units (30, 40) are configured to transmit or respectively receive the high-frequency signal, which is transmitted by the electrically conductive body of the processing device.
A computer-implemented method of identifying biomarkers in digital image of a hematoxylin and eosin, H&E, stained slide of target tissue, the method comprising: receiving the digital image to an image-based biomarker prediction system having one or more processors; performing an image tiling process, using the one or more processors, on the digital image by separating the digital image into a plurality of tile images, where each of the plurality of tile images contains a different portion of the digital image; applying, using the one or more processors, the plurality of tile images to a multiscale deep learning framework comprising one or more trained deep learning multiscale classifier models, each trained deep learning multiscale classifier models being trained to classify a different tissue classification for each tile image and determining a tissue classification for each of the plurality of tile images, using the multiscale deep learning framework; identifying, using the one or more processors, cells within the digital image using a trained cell segmentation model that processes pixels of the digital image; and from the tissue classification determined for each tile image and from the identified cells within the digital image, identifying, using the multiscale deep learning framework, a predicted presence of one or more biomarkers associated with the digital image. receiving the digital image to an image-based biomarker prediction system having one or more processors; performing an image tiling process, using the one or more processors, on the digital image by separating the digital image into a plurality of tile images, where each of the plurality of tile images contains a different portion of the digital image; applying, using the one or more processors, the plurality of tile images to a multiscale deep learning framework comprising one or more trained deep learning multiscale classifier models, each trained deep learning multiscale classifier models being trained to classify a different tissue classification for each tile image and determining a tissue classification for each of the plurality of tile images, using the multiscale deep learning framework; identifying, using the one or more processors, cells within the digital image using a trained cell segmentation model that processes pixels of the digital image; and from the tissue classification determined for each tile image and from the identified cells within the digital image, identifying, using the multiscale deep learning framework, a predicted presence of one or more biomarkers associated with the digital image.
A measurement system to determine physical displacement of a railway track (15, 200) during use of the railway track (15, 200), the system comprising: a transducer (20, 305) configured to be mounted at a connection point between a track (15, 200) and a sleeper of a track structure, the transducer being suitable for measuring a physical parameter of the track (15, 200) when a wheel of a train traverses over the track (15, 200); and a readout device operatively coupled to the transducer, the readout device being suitable for determining vertical track displacement from the physical parameter measured by the transducer, the readout device being suitable for generating a warning signal (50, 370) indicative of a degradation or failure of the track structure when the vertical track displacement exceeds a predetermined threshold; wherein the readout device coupled to the transducer is a hand-held device capable of monitoring the vertical track displacement for a maintenance determination. a transducer (20, 305) configured to be mounted at a connection point between a track (15, 200) and a sleeper of a track structure, the transducer being suitable for measuring a physical parameter of the track (15, 200) when a wheel of a train traverses over the track (15, 200); and a readout device operatively coupled to the transducer, the readout device being suitable for determining vertical track displacement from the physical parameter measured by the transducer, the readout device being suitable for generating a warning signal (50, 370) indicative of a degradation or failure of the track structure when the vertical track displacement exceeds a predetermined threshold; wherein the readout device coupled to the transducer is a hand-held device capable of monitoring the vertical track displacement for a maintenance determination.
Radiation-curable ink for an ink-jet printer containing polymerisable, unsaturated compounds, and 1 to 20 wt.% unsatured, polymerisable and condensable melamine (meth)acrylates, characterised by the addition of up to 10 wt.% reversibly blocked isocyanate curing agents and 1 to 10 wt.% multifunctional alcohols.
A shutter device comprising: a shutter plate formed with an aperture through which a photographic light flux passes; a shutter blade (41, 42) configured to close and open the aperture; a blade lever coupled with the shutter blade; a blade return spring configured to urge the blade lever in a direction in which the shutter blade opens the aperture; a drive lever configured to drive the blade lever; a blade drive spring configured to urge the drive lever; a charge cam member configured to charge the blade drive spring, the charge cam member having a charge cam portion formed thereon, wherein the charge cam portion comes into contact with the drive lever; and a hold cam member having a hold cam portion formed thereon, wherein the hold cam portion comes into contact with the blade lever to hold the blade lever so that the shutter blade closes the aperture, wherein the shutter plate is formed with a first shaft parallel to an optical axis of the photographic light flux, wherein the blade lever is arranged to rotate about the first shaft to drive the shutter blade, wherein the drive lever is arranged to rotate about the first shaft to drive the blade lever, wherein the charge cam member is arranged to rotate about a second shaft, formed on the shutter plate in parallel to the first shaft, to charge the blade drive spring, wherein the hold cam member is arranged to rotate about a third shaft, formed on the shutter plate in parallel to the first shaft, to switch between a state in which the blade lever is held so that the shutter blade closes the aperture and a state in which holding of the blade lever is released, and characterized in that the charge cam member and the hold cam member are directly coupled to each other so that the charge cam member and the hold cam member rotate at the same speed. a shutter plate formed with an aperture through which a photographic light flux passes; a shutter blade (41, 42) configured to close and open the aperture; a blade lever coupled with the shutter blade; a blade return spring configured to urge the blade lever in a direction in which the shutter blade opens the aperture; a drive lever configured to drive the blade lever; a blade drive spring configured to urge the drive lever; a charge cam member configured to charge the blade drive spring, the charge cam member having a charge cam portion formed thereon, wherein the charge cam portion comes into contact with the drive lever; and a hold cam member having a hold cam portion formed thereon, wherein the hold cam portion comes into contact with the blade lever to hold the blade lever so that the shutter blade closes the aperture, wherein the shutter plate is formed with a first shaft parallel to an optical axis of the photographic light flux, wherein the blade lever is arranged to rotate about the first shaft to drive the shutter blade,
A vibration damped enclosure, comprising side walls (5, 6; 22, 23) and a vibration damping plate structure extending across the enclosure and attached to internal surface portions of a first side wall (5, 22) and a second opposed or transverse side wall (6, 23), wherein the vibration damping plate structure comprises a relatively less rigid layer sandwiched between two relatively more rigid layers (13, 14), and wherein each relatively more rigid layer (13, 14) between said first and second side walls (5, 6; 22, 23) comprises at least one cut (15, 16) through the relatively more rigid layer (13, 14) which makes the relatively more rigid layer (13, 14) part or parts extending from the first side wall (5, 22) completely separated from the relatively more rigid layer part or parts extending from the second side wall (6, 23).
A method for manufacturing a three-dimensional article, the method comprising: a. depositing a powder on a build plate to form a powder bed; b. printing, at selected locations on the powder bed, a solution of each of: a first binding agent and a second binding agent; wherein the first and second binding agents are each printed at least once; and wherein the first and second binding agents are printed at different selected locations on the power bed; c. exposing the first and/or second binding agents to a stimulus to form a polymer layer; d. repeating steps (a)-(c) to manufacture the remainder of the three-dimensional article; and e. removing the second binding agent; characterized in that the second binding agent is a self-immolative polymer. a. depositing a powder on a build plate to form a powder bed; b. printing, at selected locations on the powder bed, a solution of each of: a first binding agent and a second binding agent; wherein the first and second binding agents are each printed at least once; and wherein the first and second binding agents are printed at different selected locations on the power bed; c. exposing the first and/or second binding agents to a stimulus to form a polymer layer; d. repeating steps (a)-(c) to manufacture the remainder of the three-dimensional article; and e. removing the second binding agent; characterized in that the second binding agent is a self-immolative polymer.
A composition comprising an N 2 -phosphinyl guanidine metal salt complex comprising a chromium salt complexed to an N 2 -phosphinyl guanidine compound.
A track mount (314; 316) for securing a track assembly (320; 219A; 219B) to a frame (110; 210; 310) of a power machine (100; 200; 300), the track mount comprising: a mounting flange (332; 334) having apertures positioned to receive fasteners to secure the mounting flange of the track mount to a side of the frame of the power machine; and a connecting structure (336; 338) for extending between the mounting flange and a track frame of the track assembly, the connecting structure securing the track frame to the frame of the power machine, the track mount being characterised in that the connecting structure (336; 338) includes an interface portion configured to be secured to a top portion of the track frame of the track assembly, the interface portion having a curvature, wherein the curvature of the interface portion matches a curvature of the track frame. a mounting flange (332; 334) having apertures positioned to receive fasteners to secure the mounting flange of the track mount to a side of the frame of the power machine; and a connecting structure (336; 338) for extending between the mounting flange and a track frame of the track assembly, the connecting structure securing the track frame to the frame of the power machine, the track mount being characterised in that the connecting structure (336; 338) includes an interface portion configured to be secured to a top portion of the track frame of the track assembly, the interface portion having a curvature, wherein the curvature of the interface portion matches a curvature of the track frame.
A method of manufacturing a magnesium-based alloy, the method comprising: - melting magnesium or magnesium alloy; - adding 0.05 % to 1.2 % by weight of calcium oxide (CaO) onto a surface of a melt in which the magnesium or magnesium alloy is melted; - exhausting the CaO through surface stirring to allow the CaO not to substantially remain in the magnesium or magnesium alloy by causing a reaction between the melt and the CaO from a surface of the melt; and - allowing calcium (Ca) produced by the reaction to react with the melt such that the Ca does not substantially remain in the magnesium or magnesium alloy, wherein the surface stirring is carried out between 1 second and 60 seconds per 0.1 % by weight of the calcium oxide added. - melting magnesium or magnesium alloy; - adding 0.05 % to 1.2 % by weight of calcium oxide (CaO) onto a surface of a melt in which the magnesium or magnesium alloy is melted; - exhausting the CaO through surface stirring to allow the CaO not to substantially remain in the magnesium or magnesium alloy by causing a reaction between the melt and the CaO from a surface of the melt; and - allowing calcium (Ca) produced by the reaction to react with the melt such that the Ca does not substantially remain in the magnesium or magnesium alloy,