A compound according to Formula I, or a pharmaceutically acceptable salt thereof wherein: A 1, A 2, A 3, and A 4 are independently C, CH, or N and bicyclic ring system E-G is selected from the group consisting of: R 5 is H, cyano, alkyl, or alkoxy; any alkyl or alkoxy group of R 5 may optionally be substituted with one, two or three halogen; ring system M is selected from the group consisting of: R 1 is H or OH; R 2 is H, alkyl, cyclopropyl, or CF 3; and R 3 and R 4 are each independently selected from H, alkyl, alkoxy, and hydroxyl alkyl; or a compound selected from the group consisting of: 4-[8-amino-3-(4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[ -4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl} -N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[ -4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1 -yl} -N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-[8-amino-3-(1-ethyl-4-hydroxy-4,5,6,7-tetrahydro-1H-indazol-4-yl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{4-amino-1-[ -1-ethyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{4-amino-1-[ -2-ethyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4- {8-amino-3-[ -1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide and 4-{8-amino-3-[ -1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide. A 1, A 2, A 3, and A 4 are independently C, CH, or N and bicyclic ring system E-G is selected from the group consisting of: R 5 is H, cyano, alkyl, or alkoxy; any alkyl or alkoxy group of R 5 may optionally be substituted with one, two or three halogen; ring system M is selected from the group consisting of: R 1 is H or OH; R 2 is H, alkyl, cyclopropyl, or CF 3; and R 3 and R 4 are each independently selected from H, alkyl, alkoxy, and hydroxyl alkyl; or R 1 is H or OH; R 2 is H, alkyl, cyclopropyl, or CF 3; and R 3 and R 4 are each independently selected from H, alkyl, alkoxy, and hydroxyl alkyl; or 4-[8-amino-3-(4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[ -4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl} -N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[ -4-hydroxy-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1 -yl} -N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-[8-amino-3-(1-ethyl-4-hydroxy-4,5,6,7-tetrahydro-1H-indazol-4-yl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{4-amino-1-[ -1-ethyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{4-amino-1-[ -2-ethyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4- {8-amino-3-[ -1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide and 4-{8-amino-3-[ -1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide.