mhurhangee/ep-ind-claims huggingface dataset:
A method for detecting a genetic variant in a region of interest in a DNA sample comprising: (i) establishing, for a given sequencing platform, sequencing process and sequencing depth, a threshold frequency at or above which the genetic variant must be observed in sequencing results of amplification reactions to assign a positive determination for the presence of the genetic variant in a given amplification reaction, wherein the threshold frequency is based on the distribution of the number of reads supporting the genetic variant expected to be observed in the sequencing results of amplification reactions due to amplification and sequencing error (read count distribution); (ii) partitioning the DNA sample into a plurality of replicate amplification reactions, so that, for the genetic variant, the mean number of amplifiable template molecules of the region of interest in a replicate amplification reaction is fewer than the reciprocal of the threshold frequency determined in step (i); (iii) performing the amplification reactions of step (ii) and sequencing the products of amplification reactions; (iv) based on step (i) and the results of step (iii), determining the presence/absence of the genetic variant in each replicate amplification reaction; and (v) integrating the results of (iv) to determine the presence/absence of the genetic variant in the region of interest in the DNA sample. (i) establishing, for a given sequencing platform, sequencing process and sequencing depth, a threshold frequency at or above which the genetic variant must be observed in sequencing results of amplification reactions to assign a positive determination for the presence of the genetic variant in a given amplification reaction, wherein the threshold frequency is based on the distribution of the number of reads supporting the genetic variant expected to be observed in the sequencing results of amplification reactions due to amplification and sequencing error (read count distribution); (ii) partitioning the DNA sample into a plurality of replicate amplification reactions, so that, for the genetic variant, the mean number of amplifiable template molecules of the region of interest in a replicate amplification reaction is fewer than the reciprocal of the threshold frequency determined in step (i); (iii) performing the amplification reactions of step (ii) and sequencing the products of amplification reactions; (iv) based on step (i) and the results of step (iii), determining the presence/absence of the genetic variant in each replicate amplification reaction; and (v) integrating the results of (iv) to determine the presence/absence of the genetic variant in the region of interest in the DNA sample.
An isolated antibody or an antigen-binding fragment thereof that binds to human transferrin receptor (TfR) and primate TfR for use in therapy wherein the antibody is transporting one or more compounds across the Blood Brain Barrier, wherein the antibody does not inhibit the binding of transferrin to TfR, wherein the antibody comprises a VH sequence of SEQ ID NO: 153 and a VL sequence of SEQ ID NO: 105.
A piping structure for a vehicle, comprising: a first replenishment opening and a second replenishment opening that are provided on a side portion of the vehicle; a first filler neck that connects a first pipe and the first replenishment opening in a space formed between a wheel house and a splash shield of the vehicle, the first pipe being routed on a front side of a wheel in a front-rear direction of the vehicle; a second filler neck that connects a second pipe and the second replenishment opening in the space, the second pipe being routed on a rear side of the wheel in the front-rear direction of the vehicle; and a neck bracket that couples the first filler neck and the second filler neck above the wheel in the space of the vehicle, wherein the wheel house covers an upper surface of the wheel and the splash shield is attached on the wheel side of the wheel house, wherein the first pipe and the second pipe are routed in the space formed between the wheel house and the splash shield. a first replenishment opening and a second replenishment opening that are provided on a side portion of the vehicle; a first filler neck that connects a first pipe and the first replenishment opening in a space formed between a wheel house and a splash shield of the vehicle, the first pipe being routed on a front side of a wheel in a front-rear direction of the vehicle; a second filler neck that connects a second pipe and the second replenishment opening in the space, the second pipe being routed on a rear side of the wheel in the front-rear direction of the vehicle; and a neck bracket that couples the first filler neck and the second filler neck above the wheel in the space of the vehicle, wherein the wheel house covers an upper surface of the wheel and the splash shield is attached on the wheel side of the wheel house, wherein the first pipe and the second pipe are routed in the space formed between the wheel house and the splash shield.
A biopsy device, comprising: a disposable needle assembly having a first cannula, a second cannula, a first cannula driver, and a second cannula driver, the first cannula driver connected to a first portion of the first cannula, the second cannula driver being connected to a first portion of the second cannula, the first cannula driver having a first rack member and a flange connected to the first rack member, the second cannula driver having a second rack member; and a drive assembly having a power source, a linear motor drive having at least one linear motor (62, 64, 66), a transmission assembly, a switching motor drive having at least one DC motor (70, 72, 74), and an electrical controller circuit, the power source configured to supply electrical power to each of the linear motor drive, the switching motor drive, and the electrical controller circuit; the electrical controller circuit configured to execute program instructions to selectively operate the linear motor drive and the switching motor drive; the transmission assembly having a gear assembly drivably coupled to the switching motor drive, the gear assembly configured to releasably engage at least one of the first rack member of the first cannula driver and the second rack member of the second cannula driver; and a coupler member connected to the linear motor drive, the coupler member configured to engage the flange of the first cannula driver. a disposable needle assembly having a first cannula, a second cannula, a first cannula driver, and a second cannula driver, the first cannula driver connected to a first portion of the first cannula, the second cannula driver being connected to a first portion of the second cannula, the first cannula driver having a first rack member and a flange connected to the first rack member, the second cannula driver having a second rack member; and a drive assembly having a power source, a linear motor drive having at least one linear motor (62, 64, 66), a transmission assembly, a switching motor drive having at least one DC motor (70, 72, 74), and an electrical controller circuit, the power source configured to supply electrical power to each of the linear motor drive, the switching motor drive, and the electrical controller circuit; the electrical controller circuit configured to execute program instructions to selectively operate the linear motor drive and the switching motor drive; the transmission assembly having a gear assembly drivably coupled to the switching motor drive, the gear assembly configured to releasably engage at least one of the first rack member of the first cannula driver and the second rack member of the second cannula driver; and a coupler member connected to the linear motor drive, the coupler member configured to engage the flange of the first cannula driver.
An aqueous shampoo composition comprising:- a. a pre-formed emulsified silicone; b. a cationic deposition polymer; c. a hair substantive cationic conditioning polymer which is a homopolymer of (3-acrylamidopropyl) trimethyl ammonium chloride; d. a cleansing surfactant; e. a co-surfactant; and f. a suspending agent. a. a pre-formed emulsified silicone; b. a cationic deposition polymer; c. a hair substantive cationic conditioning polymer which is a homopolymer of (3-acrylamidopropyl) trimethyl ammonium chloride; d. a cleansing surfactant; e. a co-surfactant; and f. a suspending agent.
A polymer coating, the coating comprising: a) one or more polymers, said polymers comprising a first cleavage site and b) a diagnostic agent that is non-covalently bound within the polymer coating, said diagnostic agent being releasable from said coating upon cleavage of said first cleavage site, wherein the first cleavage site is cleaved by a sortase enzyme specifically provided by a microbe belonging to a first group consisting of Gram positive bacteria, and not cleaved by any enzyme provided by any microbe not belonging to said first group, wherein cleavage of the said first cleavage site results in release of the said diagnostic agent from the coating, the release of said diagnostic agent being indicative for the presence of a microbe belonging to the said first group. a) one or more polymers, said polymers comprising a first cleavage site and b) a diagnostic agent that is non-covalently bound within the polymer coating, said diagnostic agent being releasable from said coating upon cleavage of said first cleavage site, wherein
An apparatus to provide suction to a wound site comprising: a spacer layer comprising a proximal end, an elongate middle portion and a distal end; a top layer constructed from a liquid impermeable material provided over the spacer layer; a bottom layer constructed from a liquid impermeable material provided below the spacer layer, wherein the top layer and the bottom layer substantially enclose the spacer layer; one or more apertures in the bottom layer beneath the distal end of the spacer layer; a filter positioned below the distal end of the spacer layer adjacent the one or more apertures; wherein the filter is positioned between the distal end of the spacer layer and the bottom layer; and a conduit in fluid communication with the proximal end of the spacer layer. a spacer layer comprising a proximal end, an elongate middle portion and a distal end; a top layer constructed from a liquid impermeable material provided over the spacer layer; a bottom layer constructed from a liquid impermeable material provided below the spacer layer, wherein the top layer and the bottom layer substantially enclose the spacer layer; one or more apertures in the bottom layer beneath the distal end of the spacer layer; a filter positioned below the distal end of the spacer layer adjacent the one or more apertures; wherein the filter is positioned between the distal end of the spacer layer and the bottom layer; and a conduit in fluid communication with the proximal end of the spacer layer.
A cleaning device comprising: a cleaning element having a first spray opening; a cleaning head having the cleaning element connected thereto; a housing defining an internal cavity, the cleaning head being connected to the housing; a pump; and a spray nozzle arranged on the cleaning head and having a fluid tight and air tight connection with an outlet of the pump; characterized by a pouch port coupled to the housing; a pouch removably stored in the internal cavity, the pouch having a connection port that forms a releasable fluid and air tight connection with the pouch port and having a cleaning fluid therein; the spray nozzle being positioned on the cleaning head so as to spray the cleaning fluid from the pouch through the first spray opening and trap the spray between the cleaning head and the surface being cleaned due to the position of the spray nozzle. a cleaning element having a first spray opening; a cleaning head having the cleaning element connected thereto; a housing defining an internal cavity, the cleaning head being connected to the housing; a pump; and a spray nozzle arranged on the cleaning head and having a fluid tight and air tight connection with an outlet of the pump; a pouch port coupled to the housing; a pouch removably stored in the internal cavity, the pouch having a connection port that forms a releasable fluid and air tight connection with the pouch port and having a cleaning fluid therein; the spray nozzle being positioned on the cleaning head so as to spray the cleaning fluid from the pouch through the first spray opening and trap the spray between the cleaning head and the surface being cleaned due to the position of the spray nozzle.
A medical instrument, comprising: a housing; a shaft coupled to the housing, the shaft having a proximal end and a distal end; an end-effector assembly disposed at the distal end of the shaft, the end-effector assembly including first and second jaw members (110, 120), at least one of the first and second jaw members movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween; a first tissue-contacting surface associated with the first jaw member; a second tissue-contacting surface associated with the second jaw member; at least one light-emitting element coupled to either one or both of the first and second jaw members, the at least one light-emitting element adapted to deliver light energy to tissue grasped between the first and second jaw members; and at least one light-detecting element configured to generate one or more signals indicative of tissue florescence; characterized by: either one or both of the first and second tissue-contacting surfaces including an absorbent coating (112a, 122a) disposed thereon, the absorbent coating configured to absorb light energy emitted from the at least one light-emitting element to heat at least a portion of at least one of the first and second jaw members. a housing; a shaft coupled to the housing, the shaft having a proximal end and a distal end; an end-effector assembly disposed at the distal end of the shaft, the end-effector assembly including first and second jaw members (110, 120), at least one of the first and second jaw members movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween; a first tissue-contacting surface associated with the first jaw member; a second tissue-contacting surface associated with the second jaw member; at least one light-emitting element coupled to either one or both of the first and second jaw members, the at least one light-emitting element adapted to deliver light energy to tissue grasped between the first and second jaw members; and at least one light-detecting element configured to generate one or more signals indicative of tissue florescence; characterized by: either one or both of the first and second tissue-contacting surfaces including an absorbent coating (112a, 122a) disposed thereon, the absorbent coating configured to absorb light energy emitted from the at least one light-emitting element to heat at least a portion of at least one of the first and second jaw members.
Electric tool, such as battery and/or AC-power tools, such as drills, sanders, saws, planes, angle grinders or the like, with an electric motor with a switch, wherein the switch has its own housing, with a circuit arrangement (6, 6') for switching the electric power supply to the electric motor in the housing on and/or off, and with an actuating member having a switching effect on the circuit arrangement (6, 6'), wherein a fuse is arranged in the manner of a high-current fuse so that, on the occurrence of a short-circuit current, the electrical voltage supply to the electric motor is interrupted independently of the actuating member, and/or an over-current device is so designed that, in the event of a failure of the circuit arrangement (6, 6'), the electrical voltage supply to the electric motor is interrupted by the over-current device, characterised in that the fuse and/or the over-current device of the circuit arrangement (6, 6') is associated with the housing.
A process comprising the following successive steps: (a) irradiating a textile with plasma; (b) contacting the irradiated textile of step (a) with a solution comprising a compound of formula: X-Y-Q, wherein X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group, under conditions allowing to form a conducting polymer at least partially coated on the textile, covalently bonded thereto, and comprising monomer units of formula: wherein X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group; and (c) contacting the coated textile of step (b) with a fluorinated carboxylic acid of formula: Q'- n -Z2, wherein n is 0 or 1, Z1 is a C 1 -C 12 aliphatic linker, Z2 is a C 1 -C 12 perfluoroalkyl, and Q' is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group, under conditions allowing to form an ester or amide bond between Q of at least one monomer unit of formula and Q' of said fluorinated carboxylic acid of formula. (a) irradiating a textile with plasma; (b) contacting the irradiated textile of step (a) with a solution comprising a compound of formula: X-Y-Q, wherein X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group, under conditions allowing to form a conducting polymer at least partially coated on the textile, covalently bonded thereto, and comprising monomer units of formula: wherein X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group; and X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group, X is a conducting monomer residue, Y is a C 1 -C 12 aliphatic linker, and Q is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group; and (c) contacting the coated textile of step (b) with a fluorinated carboxylic acid of formula: Q'- n -Z2, wherein n is 0 or 1, Z1 is a C 1 -C 12 aliphatic linker, Z2 is a C 1 -C 12 perfluoroalkyl, and Q' is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group, under conditions allowing to form an ester or amide bond between Q of at least one monomer unit of formula and Q' of said fluorinated carboxylic acid of formula. n is 0 or 1, Z1 is a C 1 -C 12 aliphatic linker, Z2 is a C 1 -C 12 perfluoroalkyl, and Q' is -OH, -NH 2, or -C OR, wherein R is a hydrogen or a C 1 -C 6 hydrocarbon group,
A metal wire rod drawing die with a die hole formed therein for inserting a metal wire rod, wherein the die hole comprises an approach section tapered in a direction in which the metal wire rod is inserted and a bearing section having a constant inner diameter located at a subsequent stage to the approach section; characterised in that where Ra1 represents a surface roughness of an inner surface of the die hole from the bearing section to the approach section corresponding to an area reduction rate of 30% in an axial direction of the die hole, Ra2 represents a surface roughness of the inner surface of the die hole from the bearing section to the approach section corresponding to the area reduction rate of 30% in a direction orthogonal to the axial direction of the die hole, and Ra3 represents a surface roughness of an inner surface of the bearing section of the die hole in the axial direction of the die hole, the Ra1, the Ra2, and the Ra3 satisfy a relationship represented by the following formula: 0.14 μm > Ra 2 > Ra 1 > Ra 3.
A method of wireless communication comprising: performing a clear channel assessment, CCA, procedure on a channel operating across multiple sub-bands of a radio frequency, RF, spectrum band; determining the channel is available based at least in part on the performed CCA; and transmitting a special header in the channel operating across multiple sub-bands, wherein the special header comprises two or more transmission time intervals, TTIs, each TTI comprising a header packet in each of two or more sub-bands. performing a clear channel assessment, CCA, procedure on a channel operating across multiple sub-bands of a radio frequency, RF, spectrum band; determining the channel is available based at least in part on the performed CCA; and transmitting a special header in the channel operating across multiple sub-bands, wherein the special header comprises two or more transmission time intervals, TTIs, each TTI comprising a header packet in each of two or more sub-bands.
A method of generating nucleotide sequence data for a nucleic acid sequencing template, comprising: providing a nucleic acid sequencing template comprising a double-stranded portion, the double stranded portion comprising two nucleic acid strands that are complementary to each other and are linked at one end by a connecting nucleic acid that links a 3' end of one strand of the two nucleic acid strands to a 5' end of another strand of the two nucleic acid strands; and performing a single-molecule sequencing process on said nucleic acid sequencing template, thereby generating nucleotide sequence data for both of said two nucleic acid strands of said nucleic acid sequencing template. providing a nucleic acid sequencing template comprising a double-stranded portion, the double stranded portion comprising two nucleic acid strands that are complementary to each other and are linked at one end by a connecting nucleic acid that links a 3' end of one strand of the two nucleic acid strands to a 5' end of another strand of the two nucleic acid strands; and performing a single-molecule sequencing process on said nucleic acid sequencing template, thereby generating nucleotide sequence data for both of said two nucleic acid strands of said nucleic acid sequencing template.
A method of erecting a pylon of a wind power installation, which has a foundation with segment anchors, wherein connecting elements are connected to the segment anchors and project beyond the top side of the foundation by a predetermined amount, comprising the steps: constructing an annular formwork of predeterminable width and height on the top side of the foundation and filling the formwork with a predeterminable amount of a fluid self-levelling grouting material, setting of the grouting material so that an exactly levelled surface is automatically achieved and removal of the formwork, placing a levelling ring having a plurality of first bores for receiving the connecting elements which project beyond the top side of the foundation on the surface of the set grouting material, and fitting and connecting a lower pylon segment having a lower flange ring with a plurality of second bores for receiving the connecting elements on the levelling ring by means of the connecting elements. constructing an annular formwork of predeterminable width and height on the top side of the foundation and filling the formwork with a predeterminable amount of a fluid self-levelling grouting material, setting of the grouting material so that an exactly levelled surface is automatically achieved and removal of the formwork, placing a levelling ring having a plurality of first bores for receiving the connecting elements which project beyond the top side of the foundation on the surface of the set grouting material, and fitting and connecting a lower pylon segment having a lower flange ring with a plurality of second bores for receiving the connecting elements on the levelling ring by means of the connecting elements.