A method to releasably engage a non-sterile powered driver with a sterile intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h) having a first end operable to penetrate a bone and associated bone marrow and to avoid contamination of the sterile intraosseous device prior to performing a medical procedure with the sterile intraosseous device comprising: removing a cover from a sterile medical procedure tray (20, 20a, 20b, 20c, 20d) comprising a holder, the holder containing a sterile coupler assembly (250, 250a, 250b, 250c) having a first end and a second end, the tray further containing a sterile containment bag having a first opening engaged proximate the second end of the sterile coupler assembly (250, 250a, 250b, 250c) and the tray further containing the sterile intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h); inserting one end of a drive shaft extending from the non-sterile powered driver through a fenestration in a drape (51, 52) covering the coupler assembly (250, 250a, 250b, 250c); engaging the one end of the drive shaft with a respective connector receptacle disposed in the second end of the coupler assembly (250, 250a, 250b, 250c); pulling the drape (51, 52) upwardly to move a second opening of the containment bag over the powered driver; continuing to pull the drape (51, 52) upwardly until the powered driver is disposed within the containment bag; closing the second opening of the containment bag with the powered driver disposed therein; removing the powered driver and the coupler assembly (250, 250a, 250b, 250c) as a single unit from the medical procedure tray (20, 20a, 20b, 20c, 20d); removing the sterile intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h) from the medical procedure tray (20, 20a, 20b, 20c, 20d); and inserting a second end of the intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h) into a respective connector receptacle disposed in the first end of the coupler assembly (250, 250a, 250b, 250c). removing a cover from a sterile medical procedure tray (20, 20a, 20b, 20c, 20d) comprising a holder, the holder containing a sterile coupler assembly (250, 250a, 250b, 250c) having a first end and a second end, the tray further containing a sterile containment bag having a first opening engaged proximate the second end of the sterile coupler assembly (250, 250a, 250b, 250c) and the tray further containing the sterile intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h); inserting one end of a drive shaft extending from the non-sterile powered driver through a fenestration in a drape (51, 52) covering the coupler assembly (250, 250a, 250b, 250c); engaging the one end of the drive shaft with a respective connector receptacle disposed in the second end of the coupler assembly (250, 250a, 250b, 250c); pulling the drape (51, 52) upwardly to move a second opening of the containment bag over the powered driver; continuing to pull the drape (51, 52) upwardly until the powered driver is disposed within the containment bag; closing the second opening of the containment bag with the powered driver disposed therein; removing the powered driver and the coupler assembly (250, 250a, 250b, 250c) as a single unit from the medical procedure tray (20, 20a, 20b, 20c, 20d); removing the sterile intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h) from the medical procedure tray (20, 20a, 20b, 20c, 20d); and inserting a second end of the intraosseous device (100, 100a, 100b, 100c, 100d, 100e, 100f, 100g, 100h) into a respective connector receptacle disposed in the first end of the coupler assembly (250, 250a, 250b, 250c).