mhurhangee/ep-ind-claims huggingface dataset:
A bispecific antibody comprising at least three binding domains comprised in one polypeptide chain, wherein (a) the first domain is a binding domain which is binding to a cell surface molecule on a target cell; and (b) the second domain is a binding domain which is binding to the T cell CD3 receptor complex; and (c) the third domain is a binding domain which is binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain, wherein the three domains are on one polypeptide in the order from the N-terminus to the C-terminus • the first binding domain; • the second binding domain; and • the third binding domain. (a) the first domain is a binding domain which is binding to a cell surface molecule on a target cell; and (b) the second domain is a binding domain which is binding to the T cell CD3 receptor complex; and (c) the third domain is a binding domain which is binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain, • the first binding domain; • the second binding domain; and • the third binding domain.
A cooling circuit for a motor vehicle comprising a first cooling loop designed to ensure the thermoregulation of a first member and at least one second cooling loop (II, III) designed to ensure the thermoregulation of a second member, the cooling circuit comprising a single degassing case which is fluidly connected to the first loop and to said at least one second cooling loop (II, III) and an isolation valve (70, 700) which is interposed between the degassing case and said at least one second cooling loop (II, III) on a return branch which ensures the return of the coolant downstream of the degassing case, characterized in that said isolation valve (70, 700) is designed to selectively seal the flow between the degassing case and said at least one second cooling loop (II, III), the isolation valve (70, 700) comprising at least one heat-sensitive bimetal element designed to act on a shutter to pass the isolation valve (70, 700)) from a passing position to a non-passing position when the coolant passing through the isolation valve reaches a trigger temperature.
A turbine ring assembly comprising a plurality of ring segments made of ceramic matrix composite material forming a turbine ring and a ring support structure, each ring segment having, along a section plane defined by an axial direction (D A) and a radial direction (D R) of the turbine ring, a part forming an annular base with, in the radial direction (D R) of the turbine ring, a radially inner face defining the inner face of the turbine ring and a radially outer face from which project a first and a second hooking tab (14, 16), the ring support structure including: - a central shroud from which project a first and a second radial flange (32, 36) from which are retained the first and second hooking tabs (14, 16) of each ring segment, - a first annular flange made of one part disposed upstream of the turbine ring and upstream of the first radial flange with respect to the direction of an air flow intended to traverse the turbine ring assembly, and having in the radial direction (D R) a first free end, a second end opposite the first end, and - a second annular flange disposed upstream of the first flange and having a first free end, a second end opposite the first end, an upstream face and a downstream face both extending in the radial direction (D R), the second ends (332, 342) of the first and second flanges (33, 34) being removably attached to said first radial flange, characterized in that the first flange comprises a shoulder projecting in the axial direction (D A) upstream from the second end of the first flange, and the second flange comprises a recess on the corner formed at the junction between the second end and the downstream face of the second flange, said recess forming an axial stop configured to cooperate by interlocking with said shoulder in the axial direction (D A). - a central shroud from which project a first and a second radial flange (32, 36) from which are retained the first and second hooking tabs (14, 16) of each ring segment, - a first annular flange made of one part disposed upstream of the turbine ring and upstream of the first radial flange with respect to the direction of an air flow intended to traverse the turbine ring assembly, and having in the radial direction (D R) a first free end, a second end opposite the first end, and - a second annular flange disposed upstream of the first flange and having a first free end, a second end opposite the first end, an upstream face and a downstream face both extending in the radial direction (D R), the second ends (332, 342) of the first and second flanges (33, 34) being removably attached to said first radial flange,
A method for monitoring a structure based on measurements of a plurality of sensors (S1, S2, S3), where each sensor (S1, S2, S3) is installed at the structure and provides measured values (x1, x2, x3) at a sampling frequency, wherein at predetermined points in time (t i): a) measured values (x1, x2, x3) of each sensor (S1, S2, S3) are subjected to a Short-time Fourier Transform (STFT), resulting, at the corresponding predetermined point in time (t i) for each sensor (S1, S2, S3), in phase values (11,... φ 3k) for each predetermined fundamental frequency out of a number of predetermined fundamental frequencies of each sensor (S1, S2, S3); characterized in that b) phase delays ( τ 12, τ 13, r23) between the phase values ( φ 11,..., φ 3k) of pairs of sensors (S1, S2, S3) are calculated for one ore more of the predetermined fundamental frequencies of all sensors (S1, S2, S3); c) the state of the structure is assigned to a normal operation condition or an abnormal operation condition based on the calculated phase delays ( τ 12, τ 13, τ 23) for said one ore more of the predetermined fundamental frequencies. a) measured values (x1, x2, x3) of each sensor (S1, S2, S3) are subjected to a Short-time Fourier Transform (STFT), resulting, at the corresponding predetermined point in time (t i) for each sensor (S1, S2, S3), in phase values (11,... φ 3k) for each predetermined fundamental frequency out of a number of predetermined fundamental frequencies of each sensor (S1, S2, S3); b) phase delays ( τ 12, τ 13, r23) between the phase values ( φ 11,..., φ 3k) of pairs of sensors (S1, S2, S3) are calculated for one ore more of the predetermined fundamental frequencies of all sensors (S1, S2, S3); c) the state of the structure is assigned to a normal operation condition or an abnormal operation condition based on the calculated phase delays ( τ 12, τ 13, τ 23) for said one ore more of the predetermined fundamental frequencies.
Feedthrough, comprising at least one conductor with a cross-section in a glass or glass-ceramic material for insertion into an opening (9007.1, 9007.2, 10007.1, 10007.2) formed in a housing part of a housing, characterized in that the conductor (7003.1, 7003.2, 7003.2, 9003.1, 9003.2, 10003.1, 10003.2) has at least two sections, a first section (9005.1, 9005.2, 10005.1, 10005.2) having a first, substantially round, in particular circular cross-section with a diameter ID, wherein the first section (9005.1, 9005.2, 10005.1, 10005.2) of the conductor in the feedthrough is glazed into a glass or glass-ceramic material, and a second section (9009.1, 9009.2, 10009.1, 1009.2) having a second, non-round, in particular a substantially rectangular cross-section, wherein the conductor is integral with the first and second sections, wherein the substantially rectangular cross-section of the second section of the conductor substantially corresponds with respect to its area to the area of the substantially round cross-section of the first section of the conductor.
Gearshift control method for a motor vehicle, the drive train of which comprises a drive engine which is embodied as a turbo-charged internal combustion engine, a starter and shift clutch which is embodied as an automated friction clutch, and a transmission which is embodied as an automated step-by-step variable speed transmission, wherein a traction weakness of the drive engine which occurs during the load build-up at the end of a traction upshift is avoided, characterized in that the drive engine accelerates at the earliest after the disengagement of the load gear speed and at the earliest at the start of the load build-up after the engagement of the target gear speed up to the charge limit rotational speed (n L_min) or an engine rotational speed (n M) which is slightly above the charge limit rotational speed (n L_min) (n M =n L_min; n M =n L_min +Δn M), and during the load build-up with largely constant engine rotational speed (n m ≈n L_min) is loaded beyond the suction torque (M S) of the drive engine to close to the full load torque (M VL (n L_min)) before the slip operation of the friction clutch is ended.
A pump apparatus comprising a pump chamber having a fluid inlet and a fluid outlet; and a flexible impeller mounted for rotation within the pump chamber, wherein the pump chamber is defined by a curved wall, the wall including a first wall portion having a first radius and a second wall portion having a second radius, wherein the second radius is greater than the first radius; the flexible impeller includes a plurality of radially extending vanes, wherein the vanes contact the curved wall of the pump chamber such that separate pump cavities are defined between adjacent vanes and the pump chamber wall; the flexible impeller is driven to rotate by a drive shaft; the drive shaft passes through a first end wall which closes one side of the pump chamber; a second end wall closes the opposite side of the pump chamber; the fluid inlet and the fluid outlet are defined in the second end wall; the curved wall of the pump chamber is defined by a sleeve; and wherein the pump apparatus further includes a connector which connects the pump apparatus to a motor; characterised in that a distal end of the drive shaft rotates within a bearing defined by the second end wall; the sleeve defines an outer wall having a circular cross-section and the sleeve is located within a pump body; and wherein the connector defines the first end wall.
A gasket, comprising: a first functional layer extending from a first edge surrounding a combustion chamber opening to a second edge; a portion of said first functional layer extending in a first direction to present a first full bead around said combustion chamber opening; a portion of said first functional layer extending in said first direction to present a first half bead disposed between said first full bead and said second edge; a second functional layer extending from a third edge surrounding said combustion chamber opening to a fourth edge; a portion of said second functional layer extending in a second direction opposite said first direction to present a second full bead axially aligned with said first full bead; a portion of said second functional layer extending in said second direction to present a second half bead axially aligned with said first half bead; a stopper disposed between said functional layers (22, 36) and extending between a fifth edge and a sixth edge, said stopper including a fold over presenting an increased thickness between said fifth edge and said full beads (32, 38), characterised in that said sixth edge is disposed radially between said full beads (32, 38) and said half beads (34, 40). a first functional layer extending from a first edge surrounding a combustion chamber opening to a second edge; a portion of said first functional layer extending in a first direction to present a first full bead around said combustion chamber opening; a portion of said first functional layer extending in said first direction to present a first half bead disposed between said first full bead and said second edge; a second functional layer extending from a third edge surrounding said combustion chamber opening to a fourth edge; a portion of said second functional layer extending in a second direction opposite said first direction to present a second full bead axially aligned with said first full bead; a portion of said second functional layer extending in said second direction to present a second half bead axially aligned with said first half bead; a stopper disposed between said functional layers (22, 36) and extending between a fifth edge and a sixth edge, said stopper including a fold over presenting an increased thickness between said fifth edge and said full beads (32, 38), characterised in that said sixth edge is disposed radially between said full beads (32, 38) and said half beads (34, 40).
Actuating device for selecting gear stages for a change-speed transmission, in particular for an automatic transmission with shift-by-wire actuation, it being possible for a selector lever of the actuating device to be moved in a main gate and a tapping gate and in a switching gate between the main gate and the tapping gate, the actuating device comprising a latching device which acts on the selector lever, the actuating device having a locking device which comprises a locking gate, an actuator and a locking bolt which is guided by way of the actuator, the actuator moving the locking bolt, the locking gate having at least one locking depression, the locking device having a spring (124; 824), characterized in that, in the case of a position of the selector lever within the main gate, the locking bolt can be moved by way of the actuator, and the locking bolt is configured to engage into the locking depression, a holding force which is brought about by way of the spring (124; 824) and brings it about that the locking device is held in a position as long as no force which exceeds the holding force is exerted on an element of the actuating device being greater than a restoring force of the latching device of the actuating device, which restoring force acts from a position of the selector lever in the tapping gate into a position in the main gate, and the spring (124; 824) being configured to act counter to a movement of the selector lever out of the tapping gate into the main gate if the selector lever is positioned in the tapping gate.
Method for producing transition metal oxide particles having general formula: LiMn 1.5+y Ni 0.5-y-z M z O 4, wherein M comprises one or more elements from the group of Co, Mg, Fe and Zn, y is a value from 0 to less than 0.5, z is a value from 0 to 0.1, and (y+z) is a value less than 0.5, the method comprising the steps of: (a) reacting an aqueous solution of manganese salts, nickel salts and optional one or more further salts of the elements Co, Mg, Fe and Zn with an aqueous solution of an alkali metal hydroxide and NH 3 to precipitate a lithium-free transition metal precursor from the reaction mixture, wherein the molar starting ratio of OH - ions to metal ions (OH -:M 2+)<1.95 and wherein the concentration of NH 4 + ions in the reaction mixture after establishing a chemical equilibrium is 0.05 mol/l or more, (b) isolating and optionally drying the precipitated lithium-free transition metal precursor from the reaction mixture, (c) reacting the lithium-free transition metal precursor with an aqueous solution of a thermally decomposable lithium compound to obtain a lithium-containing transition metal precursor, and (d) calcining the lithium-containing transition metal precursor at a temperature of 300 °C - 800 °C. wherein M comprises one or more elements from the group of Co, Mg, Fe and Zn, y is a value from 0 to less than 0.5, z is a value from 0 to 0.1, and (y+z) is a value less than 0.5, the method comprising the steps of: (a) reacting an aqueous solution of manganese salts, nickel salts and optional one or more further salts of the elements Co, Mg, Fe and Zn with an aqueous solution of an alkali metal hydroxide and NH 3 to precipitate a lithium-free transition metal precursor from the reaction mixture, wherein the molar starting ratio of OH - ions to metal ions (OH -:M 2+)<1.95 and wherein the concentration of NH 4 + ions in the reaction mixture after establishing a chemical equilibrium is 0.05 mol/l or more, (b) isolating and optionally drying the precipitated lithium-free transition metal precursor from the reaction mixture, (c) reacting the lithium-free transition metal precursor with an aqueous solution of a thermally decomposable lithium compound to obtain a lithium-containing transition metal precursor, and (d) calcining the lithium-containing transition metal precursor at a temperature of 300 °C - 800 °C. (a) reacting an aqueous solution of manganese salts, nickel salts and optional one or more further salts of the elements Co, Mg, Fe and Zn with an aqueous solution of an alkali metal hydroxide and NH 3 to precipitate a lithium-free transition metal precursor from the reaction mixture, (b) isolating and optionally drying the precipitated lithium-free transition metal precursor from the reaction mixture, (c) reacting the lithium-free transition metal precursor with an aqueous solution of a thermally decomposable lithium compound to obtain a lithium-containing transition metal precursor, and (d) calcining the lithium-containing transition metal precursor at a temperature of 300 °C - 800 °C.
A compound of formula: or a salt thereof, wherein: R 1 is H, (C 1 -C 6)alkyl, or (C 1 -C 6)alkanoyl; n is an integer in the range of from about 10 to about 150; and L is absent and X is -C(=O)NR 2 R 3; or L is (C 1 -C 6)alkyl and X is selected from the group consisting of -N(R 4)C(=O)CH(R 2)(R 3), -OCH(R 2)(R 3), -C(=O)OCH 2 CH(R 2)(R 3), -N(R 4)C(=O)N(R 2)(R 3), and -SO 2 N(R 2)(R 3); R 2 is (C 10 -C 20)alkyl; R 3 is (C 10 -C 20)alkyl; and R 4 is H or (C 1 -C 6)alkyl. R 1 is H, (C 1 -C 6)alkyl, or (C 1 -C 6)alkanoyl; n is an integer in the range of from about 10 to about 150; and L is absent and X is -C(=O)NR 2 R 3; or L is (C 1 -C 6)alkyl and X is selected from the group consisting of -N(R 4)C(=O)CH(R 2)(R 3), -OCH(R 2)(R 3), -C(=O)OCH 2 CH(R 2)(R 3), -N(R 4)C(=O)N(R 2)(R 3), and -SO 2 N(R 2)(R 3); R 2 is (C 10 -C 20)alkyl; R 3 is (C 10 -C 20)alkyl; and R 4 is H or (C 1 -C 6)alkyl.
A line pattern projector, comprising: a light source array, including a plurality of light sources (420_1-420_4) that emit light beams, wherein the plurality of light sources are arranged along a first direction; a lens, configured to collimate the light beams; and a diffractive microlens array, MLA, configured to diffract the collimated light beams thereby to project an illumination pattern, wherein a lens pitch of the diffractive MLA with respect to the first direction is wider than a lens pitch of the diffractive MLA with respect to a second direction; wherein the illumination pattern is formed by overlapping multiple dot patterns that are projected by the light sources (420_1-420_4); and the illumination pattern includes a plurality of line light patterns in the first direction. a light source array, including a plurality of light sources (420_1-420_4) that emit light beams, wherein the plurality of light sources are arranged along a first direction; a lens, configured to collimate the light beams; and a diffractive microlens array, MLA, configured to diffract the collimated light beams thereby to project an illumination pattern, wherein a lens pitch of the diffractive MLA with respect to the first direction is wider than a lens pitch of the diffractive MLA with respect to a second direction; wherein the illumination pattern is formed by overlapping multiple dot patterns that are projected by the light sources (420_1-420_4); and the illumination pattern includes a plurality of line light patterns in the first direction.
A particulate product comprising at least 10 wt.% of coated lactate particles having the following characteristics: • comprising one or more carrier particles containing at least 80 wt.% of calcium lactate component selected from calcium lactate hydrates, calcium lactate anhydrous and combinations thereof; • comprising a coating layer that covers the one or more carrier particles, said coating layer containing at least 60 wt.% of sodium lactate; • containing sodium and calcium in a molar ratio of 2.1:1 to 5:1; and • a particle size in the range of 120 to 1,200 μm. • comprising one or more carrier particles containing at least 80 wt.% of calcium lactate component selected from calcium lactate hydrates, calcium lactate anhydrous and combinations thereof; • comprising a coating layer that covers the one or more carrier particles, said coating layer containing at least 60 wt.% of sodium lactate; • containing sodium and calcium in a molar ratio of 2.1:1 to 5:1; and • a particle size in the range of 120 to 1,200 μm.
A nonaqueous electrolyte secondary battery comprising a positive electrode, a negative electrode, and a nonaqueous electrolytic solution, wherein the positive electrode includes a positive electrode active material layer; the positive electrode active material layer includes Li 3 PO 4, Li 2 WO 4, and, as a positive electrode active material, a lithium transition metal complex oxide including at least lithium, nickel, manganese, and cobalt; a mass ratio of Li 3 PO 4 to the positive electrode active material is 1% by mass or more and 5% by mass or less; and a mass ratio of Li 2 WO 4 to the positive electrode active material is 0.2% by mass or more and 0.9% by mass or less. the positive electrode includes a positive electrode active material layer; the positive electrode active material layer includes Li 3 PO 4, Li 2 WO 4, and, as a positive electrode active material, a lithium transition metal complex oxide including at least lithium, nickel, manganese, and cobalt; a mass ratio of Li 3 PO 4 to the positive electrode active material is 1% by mass or more and 5% by mass or less; and a mass ratio of Li 2 WO 4 to the positive electrode active material is 0.2% by mass or more and 0.9% by mass or less.
A method of controlling the cooling rate of a melt pool of a powder bed, comprising: directing a first laser beam on the powder bed to form a melt pool; coaxially combining a second laser beam with the first laser beam; and offsetting a focus spot of the second laser beam with respect to the melt pool, wherein the second laser beam heats but does not melt powder within the focus spot; and being characterised by: scanning the first laser beam and the offset second laser beam relative to the powder bed by offsetting the focus spot of the second laser beam in a pattern around the melt pool, wherein the pattern comprises a wobble pattern, as shown in figure 4. directing a first laser beam on the powder bed to form a melt pool; coaxially combining a second laser beam with the first laser beam; and offsetting a focus spot of the second laser beam with respect to the melt pool, wherein the second laser beam heats but does not melt powder within the focus spot; and being characterised by: scanning the first laser beam and the offset second laser beam relative to the powder bed by offsetting the focus spot of the second laser beam in a pattern around the melt pool, wherein the pattern comprises a wobble pattern, as shown in figure 4.
A composition comprising recombinant follicle stimulating hormone and recombinant human chorionic gonadotropin (hCG) for use in the treatment of infertility in a patient having serum AMH level <15 pmol/L, wherein the recombinant FSH is to be administered at a dose of, or equivalent to, 11 to 13 μg per day, and the recombinant hCG is to be administered such that the ratio by weight of the dose per day of recombinant FSH to the dose per day of recombinant hCG (daily dose of rFSH in μg: daily dose of rhCG in μg) is from 15:1 to 1:1, for example 3:1 to 1.5:1.
A pharmaceutical composition comprising a Vaccinium bracteatum Thunb. leaf extract as an effective ingredient for use in the prevention or treatment of stress-related anxiety and depression; wherein the Vaccinium bracteatum Thunb. leaf extract is obtained using one selected from water, methanol, and a mixture thereof as an extraction solvent.