mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition, comprising: (a) a glucokinase activator, wherein the glucokinase activator is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled compound, a crystalline form, a hydrate, or a solvate thereof, and (b) a biguanide hypoglycemic drug, wherein the weight ratio of the glucokinase activator to the biguanide hypoglycemic drug is about 1:50 to 1:1. (a) a glucokinase activator, wherein the glucokinase activator is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled compound, a crystalline form, a hydrate, or a solvate thereof, and (b) a biguanide hypoglycemic drug,
A method, comprising: at a GPIO interface, receiving a transmit set of GPIO signals; from the GPIO interface, transmitting a first portion of the GPIO signals over GPIO pins; from the GPIO interface, providing a second portion of the GPIO signals to a finite state machine, FSM,, wherein the second portion of the GPIO signals are arranged in a series of bit pairs; for each bit pair received at the FSM: based upon a first bit in the bit pair, selecting between at least two different pulse widths to provide a selected pulse width; based upon a second bit in the bit pair, selecting between a rising edge alignment for the selected pulse width with a beginning of a symbol period and a falling edge alignment for the selected pulse width with an end of the symbol period to provide a selected edge alignment; and transmitting a virtual GPIO pulse over a transmit pin within the symbol period according to the selected pulse width and the selected edge alignment, the virtual GPIO pulse equaling a power supply voltage during the selected pulse width and equaling ground outside of the selected pulse width. at a GPIO interface, receiving a transmit set of GPIO signals; from the GPIO interface, transmitting a first portion of the GPIO signals over GPIO pins; from the GPIO interface, providing a second portion of the GPIO signals to a finite state machine, FSM,, wherein the second portion of the GPIO signals are arranged in a series of bit pairs; for each bit pair received at the FSM: based upon a first bit in the bit pair, selecting between at least two different pulse widths to provide a selected pulse width; based upon a second bit in the bit pair, selecting between a rising edge alignment for the selected pulse width with a beginning of a symbol period and a falling edge alignment for the selected pulse width with an end of the symbol period to provide a selected edge alignment; and transmitting a virtual GPIO pulse over a transmit pin within the symbol period according to the selected pulse width and the selected edge alignment, the virtual GPIO pulse equaling a power supply voltage during the selected pulse width and equaling ground outside of the selected pulse width. based upon a first bit in the bit pair, selecting between at least two different pulse widths to provide a selected pulse width; based upon a second bit in the bit pair, selecting between a rising edge alignment for the selected pulse width with a beginning of a symbol period and a falling edge alignment for the selected pulse width with an end of the symbol period to provide a selected edge alignment; and transmitting a virtual GPIO pulse over a transmit pin within the symbol period according to the selected pulse width and the selected edge alignment, the virtual GPIO pulse equaling a power supply voltage during the selected pulse width and equaling ground outside of the selected pulse width.
Actuator for controlling at least one fluid path (20, 20') of a filling unit for a beverage filling system, said actuator having at least one control unit and at least one actuator element (24, 24'), by means of which the actuator element (24, 24') has a seat part (5, 5') that is stationary relative to a seat, and a closure part (6, 6') which is movable relative to the seat, wherein at least one first control signal and at least one second control signal can be provided by means of the control unit, and wherein at least the closure part (6, 6') of the actuator element (24, 24') consists of a material which adopts a first form according to the first control signal, in which the actuator element (24, 24') assumes a first, rest position, and which adopts a second form according to the second control signal, in which the actuator element (24, 24') assumes a second, engagement position, wherein the material of the actuator element (24, 24') is or comprises a magnetorheological elastomer, wherein it comprises at least one electromagnet (2, 7), wherein the actuator element (24, 24') is located in the variable magnetic field of the electromagnet (2, 7), and the magnetic field of the electromagnet (2, 7) can be varied by the first and second control signals, wherein the actuator element (24, 24') is a fluid valve membrane (16, 16') and the closure part (6, 6') is a constituent part of the fluid valve membrane (16, 16').
Method for transferring a semiconductor layer from a donor substrate comprising a weakening plane to a receiver substrate comprising a bonding face that has open cavities, comprising the implementation, by putting the donor substrate and the bonding face of the receiver substrate in contact, of an assembly wherein said cavities are buried and the separation of the assembly by fracture alone the weakening plane, in which method the bonding face of the receiver substrate includes, apart from the open cavities, a bonding surface that comes into contact with the donor substrate when the assembly is implemented, said bonding surface comprises a region devoid of cavities (5, 6), one dimension of which is at least 100 μm and which has a surface area of at least 1 mm 2, and an intercavity space that occupies from 15 to 50% of the bonding face of the receiver substrate.
Apparatus for the sublimation of chemical compounds, comprising an oven, a sublimer unit, a condensation unit, which is in contact with the sublimer unit, a rotation drive for rotation of the sublimer unit and condensation unit, and a vacuum pump or vacuum-pump system, characterised in that the apparatus has, between the rotating part and the fixed part, a rotation coupling, which is selected from a rotary feedthrough with ferrofluidic seal or a double- or triple-acting mechanical face seal and in that the sublimer unit and the condensation unit are surrounded by a tube and the vacuum is applied to the surrounding tube.
A pharmaceutical composition comprising an antibody or antigen-binding fragment thereof that specifically binds an interleukin-4 receptor (IL-4R) for use in a method of treating nasal polyposis in a subject in need thereof, wherein the antibody or antigen-binding fragment thereof comprises three HCDRs (HCDR1, HCDR2 and HCDR3) and three LCDRs (LCDR1, LCDR2 and LCDR3), wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO:3, the HCDR2 comprises the amino acid sequence of SEQ ID NO:4, the HCDR3 comprises the amino acid sequence of SEQ ID NO:5, the LCDR1 comprises the amino acid sequence of SEQ ID NO:6, the LCDR2 comprises the amino acid sequence of SEQ ID NO:7, and the LCDR3 comprises the amino acid sequence of SEQ ID NO:8, and wherein nasal polyposis is optionally bilateral nasal polyposis.
A method of improving a protein binding site, the method comprising the steps of: synthesizing a single substitution library for each of a plurality of domains of a protein binding site, wherein each member of a single substitution library has a nucleotide sequence that encodes amino acid changes at a single amino acid position of its associated domain and that overlaps a nucleotide sequence of at least one member of a different single substitution library, and wherein the domains of the protein binding site are singlely substituted at from 1 to 250 amino acid positions; expressing separately each member of each single substitution library as a pre-candidate protein; selecting the pre-candidate proteins of each single substitution library which bind to target molecules to form a selected library for each domain of the protein; shuffling members of the selected libraries in a PCR to produce a combinatorial shuffled library; expressing members of the shuffled library as candidate proteins; incubating in a reaction mixture under binding conditions the candidate proteins with target molecules; washing the target molecules until a fraction of candidate proteins remain bound; and selecting members of the shuffled library which encode candidate proteins remaining bound to the target molecules. synthesizing a single substitution library for each of a plurality of domains of a protein binding site, wherein each member of a single substitution library has a nucleotide sequence that encodes amino acid changes at a single amino acid position of its associated domain and that overlaps a nucleotide sequence of at least one member of a different single substitution library, and wherein the domains of the protein binding site are singlely substituted at from 1 to 250 amino acid positions; expressing separately each member of each single substitution library as a pre-candidate protein; selecting the pre-candidate proteins of each single substitution library which bind to target molecules to form a selected library for each domain of the protein; shuffling members of the selected libraries in a PCR to produce a combinatorial shuffled library; expressing members of the shuffled library as candidate proteins; incubating in a reaction mixture under binding conditions the candidate proteins with target molecules; washing the target molecules until a fraction of candidate proteins remain bound; and selecting members of the shuffled library which encode candidate proteins remaining bound to the target molecules.
A boom coaster, comprising: a passenger vehicle; a track (12; 14); a bogie (18; 22) coupled to the passenger vehicle and the track (12; 14) and configured to move along the track (12; 14); and a simulated ride surface positioned above the track (12; 14) and beneath the passenger vehicle; wherein the simulated ride surface is configured to imitate a path of the passenger vehicle, the bogie (18; 22) is coupled to a surface of the passenger vehicle via a leg member extending around the simulated ride surface, the leg member is coupled to the surface of the passenger vehicle via a rotational joint positioned at a center of gravity of the passenger vehicle, the rotational joint is configured to maintain a substantially level orientation of the passenger vehicle with respect to Earth as the bogie (18; 22) moves along various changes in the track (12; 14), and the leg member suspends the passenger vehicle above the simulated ride surface such that the bogie (18; 22) and the track (12; 14) are blocked from a passenger view perspective of the passenger vehicle. a passenger vehicle; a track (12; 14); a bogie (18; 22) coupled to the passenger vehicle and the track (12; 14) and configured to move along the track (12; 14); and a simulated ride surface positioned above the track (12; 14) and beneath the passenger vehicle; wherein the simulated ride surface is configured to imitate a path of the passenger vehicle, the bogie (18; 22) is coupled to a surface of the passenger vehicle via a leg member extending around the simulated ride surface, the leg member is coupled to the surface of the passenger vehicle via a rotational joint positioned at a center of gravity of the passenger vehicle, the rotational joint is configured to maintain a substantially level orientation of the passenger vehicle with respect to Earth as the bogie (18; 22) moves along various changes in the track (12; 14), and the leg member suspends the passenger vehicle above the simulated ride surface such that the bogie (18; 22) and the track (12; 14) are blocked from a passenger view perspective of the passenger vehicle.
An information transmission method in a control convergence-based core network architecture, wherein a convergence control plane of the control convergence-based core network architecture includes a network element selector, NES, and a plurality of controllers, each of the controllers implementing functions of registration management, authentication management, mobility management and paging management, comprising: receiving, by the NES, a first message from an external network element, wherein the first message comprises identification information of user equipment, UE; determining, by the NES based on the identification information of the UE, a first user group to which the UE belongs; determining, by the NES, a first controller corresponding to the first user group based on a preset correspondence between a user group and a controller; and sending, by the NES, the first message to the first controller, characterized in that the method further comprises: receiving, by the NES, a fourth message, wherein the fourth message comprises an identifier of a third controller and a user group list migrated from the first controller to the third controller; and adding, by the NES in the preset correspondence between a user group and a controller, the user group list migrated to the third controller to a correspondence to the third controller in the preset correspondence, and deleting the user group list migrated to the third controller from a correspondence to the first controller in the preset correspondence. receiving, by the NES, a first message from an external network element, wherein the first message comprises identification information of user equipment, UE; determining, by the NES based on the identification information of the UE, a first user group to which the UE belongs; determining, by the NES, a first controller corresponding to the first user group based on a preset correspondence between a user group and a controller; and sending, by the NES, the first message to the first controller, characterized in that the method further comprises: receiving, by the NES, a fourth message, wherein the fourth message comprises an identifier of a third controller and a user group list migrated from the first controller to the third controller; and adding, by the NES in the preset correspondence between a user group and a controller, the user group list migrated to the third controller to a correspondence to the third controller in the preset correspondence, and deleting the user group list migrated to the third controller from a correspondence to the first controller in the preset correspondence. receiving, by the NES, a fourth message, wherein the fourth message comprises an identifier of a third controller and a user group list migrated from the first controller to the third controller; and adding, by the NES in the preset correspondence between a user group and a controller, the user group list migrated to the third controller to a correspondence to the third controller in the preset correspondence, and deleting the user group list migrated to the third controller from a correspondence to the first controller in the preset correspondence.
Process for cleaning soiled metal surfaces characterized in such cleaning is carried out using a composition that comprises at least one alkoxylated polyethylenimine with a polydispersity Q = M w /M n in the range of from 3.5 to 10 and an average molecular weight M w in the range of from 2,500 to 1,500,000 g/mol, wherein said alkoxylated polyethylenimine contains backbone and alkylene oxide units in a weight ratio in the range of from 1: 2 to 1: 50.
A method for determining that a subject having scleroderma is at a lower risk for cancer comprising: detecting the presence of: (i) an anti-RNA polymerase III antibody in a biological sample obtained from the subject; and (ii) an anti-RPA194 antibody in a biological sample obtained from the subject; and determining that the subject has a lower risk for cancer when: (i) the presence of the anti-RNA polymerase III antibody is detected, and (ii) the presence of the anti-RPA194 antibody is detected. detecting the presence of: (i) an anti-RNA polymerase III antibody in a biological sample obtained from the subject; and (ii) an anti-RPA194 antibody in a biological sample obtained from the subject; and (i) an anti-RNA polymerase III antibody in a biological sample obtained from the subject; and (ii) an anti-RPA194 antibody in a biological sample obtained from the subject; and determining that the subject has a lower risk for cancer when: (i) the presence of the anti-RNA polymerase III antibody is detected, and (ii) the presence of the anti-RPA194 antibody is detected. (i) the presence of the anti-RNA polymerase III antibody is detected, and (ii) the presence of the anti-RPA194 antibody is detected.
An electronic device comprising: a body comprising a first bending region a flexible display stack comprising at least one active layer and a rigid supporting layer; wherein the rigid supporting layer is positioned on the bottom of the flexible display stack; wherein the rigid supporting layer of the flexible display stack includes a second bendable region of the supporting layer itself, and one or more fastening areas on either side and separated from the second bendable region, wherein the second bendable region is different from the first bendable region; and the body includes one or more fastening components operable in a movable connection with respective fastening areas of the rigid supporting layer of the flexible display stack to form a movable connection between the body and the rigid supporting layer; characterised in that: the one or more fastening areas comprise one or more first magnetic elements and the one or more fastening components comprise one or more second magnetic elements for cooperation with the one or more first magnetic elements and wherein the rigid supporting layer comprises a magnetic core between the magnetic elements and other layers of the flexible display stack. a body comprising a first bending region a flexible display stack comprising at least one active layer and a rigid supporting layer; wherein the rigid supporting layer is positioned on the bottom of the flexible display stack; wherein the rigid supporting layer of the flexible display stack includes a second bendable region of the supporting layer itself, and one or more fastening areas on either side and separated from the second bendable region, wherein the second bendable region is different from the first bendable region; and the body includes one or more fastening components operable in a movable connection with respective fastening areas of the rigid supporting layer of the flexible display stack to form a movable connection between the body and the rigid supporting layer; characterised in that: the one or more fastening areas comprise one or more first magnetic elements and the one or more fastening components comprise one or more second magnetic elements for cooperation with the one or more first magnetic elements and wherein the rigid supporting layer comprises a magnetic core between the magnetic elements and other layers of the flexible display stack. the one or more fastening areas comprise one or more first magnetic elements and the one or more fastening components comprise one or more second magnetic elements for cooperation with the one or more first magnetic elements and wherein the rigid supporting layer comprises a magnetic core between the magnetic elements and other layers of the flexible display stack.
A method for refreshing addresses, characterized by comprising: when a state switching between a link fault and a fault recovery occurs in a link, a node where a port related to said link is situated refreshing an address forwarding list and then configuring a flag PF on other ports of said node, and sending protocol message with address refreshing information to other nodes; wherein the flag PF is used for indicating to suspend an operation of refreshing an address forwarding list; and a node to which a port receiving said address refreshing information belongs refreshing the address forwarding list only when identifier information included in said protocol message is inconsistent with identifier information stored in the port receiving said protocol message and this port is not configured with said PF flag. when a state switching between a link fault and a fault recovery occurs in a link, a node where a port related to said link is situated refreshing an address forwarding list and then configuring a flag PF on other ports of said node, and sending protocol message with address refreshing information to other nodes; wherein the flag PF is used for indicating to suspend an operation of refreshing an address forwarding list; and a node to which a port receiving said address refreshing information belongs refreshing the address forwarding list only when identifier information included in said protocol message is inconsistent with identifier information stored in the port receiving said protocol message and this port is not configured with said PF flag.
System for storing a liquid additive intended to be injected into the exhaust gases from an internal combustion engine of a vehicle, comprising: an additive storage tank comprising means for setting a maximum filling level of the tank, a filler mouthpiece discharging into the tank and adapted for connection to a filler tube of the tank, an additive retention capacity which fluidically communicates with the tank, said capacity being designed so as to retain additive coming from the tank, characterized in that the system comprises: a ventilation mouthpiece adapted for attachment to a ventilation tube connecting the capacity to the filler tube of the tank at a point situated outside the tank and the capacity, and in that the additive retention capacity and the tank are adjacent and comprise at least one common wall. an additive storage tank comprising means for setting a maximum filling level of the tank, a filler mouthpiece discharging into the tank and adapted for connection to a filler tube of the tank, an additive retention capacity which fluidically communicates with the tank, said capacity being designed so as to retain additive coming from the tank, characterized in that the system comprises: a ventilation mouthpiece adapted for attachment to a ventilation tube connecting the capacity to the filler tube of the tank at a point situated outside the tank and the capacity, and in that the additive retention capacity and the tank are adjacent and comprise at least one common wall. a ventilation mouthpiece adapted for attachment to a ventilation tube connecting the capacity to the filler tube of the tank at a point situated outside the tank and the capacity, and in that the additive retention capacity and the tank are adjacent and comprise at least one common wall.
A method for producing a rodent comprising inserting into a rodent ES cell genome a plurality of human IgH V regions, one or more human D regions and one or more human J regions upstream of the host rodent heavy chain constant region; wherein the insertion of the human heavy chain DNA is made between the rodent constant region and the last, 3', rodent J region; wherein the insertion is carried out in a stepwise manner; wherein the insertion is such that the rodent is able to produce a repertoire of chimaeric antibodies or heavy chains having a rodent constant region and a human variable region; and the method comprises modifying the rodent genome to prevent expression of the fully host species specific antibodies in the rodent by inactivation of all or a part of the host rodent Ig loci, wherein said modifying is achieved by insertion of one or more site specific recombinase sites into the genome and then use of these sites in recombinase-mediated excision or inversion of all or a part of the rodent Ig locus.