A method of determining concentrations of a plurality of analytes from a single blood sample, the method comprising: (a) contacting said single blood sample with a top surface of an elongated disbursement layer of a hybrid test strip and spreading said single blood sample substantially throughout an entire length of said disbursement layer; (b) contacting said single blood sample with a sample area such that a portion of said single blood sample is drawn to the sample area by passing through the disbursement layer; (c) delivering said single blood sample from said disbursement layer to a first stack, a second stack, and a third stack of the hybrid test strip, each of said first, second, and third stacks positioned adjacent to and in constant contact with said disbursement layer; (d) moving the sample downward through the stacks in a direction substantially normal to the plane defined by the stacks; (e) producing a colored response at the bottom of each of the three stacks, the colored response at the bottom of the first stack being proportional to the concentration of a first analyte in the blood sample, the colored response at the bottom of the second stack being proportional to the concentration of a second analyte in the blood sample, and the colored response at the bottom of the third stack being proportional to the concentration of a third analyte in the blood sample; (f) delivering a portion of the single blood sample from said blood separation layer to an electrochemical testing member containing an electrode and a counter-electrode, the electrode and the counter-electrode being integrated with the hybrid test strip such that the electrode and the counter-electrode are immediately adjacent to said disbursement layer, or such that a stack below said disbursement layer brings blood to the electrode and the counter-electrode; and (g) measuring an electrical property of the single blood sample using the electrode and counter-electrode wherein the electrical property is proportional to the concentration of a fourth analyte in the blood sample. (a) contacting said single blood sample with a top surface of an elongated disbursement layer of a hybrid test strip and spreading said single blood sample substantially throughout an entire length of said disbursement layer; (b) contacting said single blood sample with a sample area such that a portion of said single blood sample is drawn to the sample area by passing through the disbursement layer; (c) delivering said single blood sample from said disbursement layer to a first stack, a second stack, and a third stack of the hybrid test strip, each of said first, second, and third stacks positioned adjacent to and in constant contact with said disbursement layer; (d) moving the sample downward through the stacks in a direction substantially normal to the plane defined by the stacks; (e) producing a colored response at the bottom of each of the three stacks, the colored response at the bottom of the first stack being proportional to the concentration of a first analyte in the blood sample, the colored response at the bottom of the second stack being proportional to the concentration of a second analyte in the blood sample, and the colored response at the bottom of the third stack being proportional to the concentration of a third analyte in the blood sample; (f) delivering a portion of the single blood sample from said blood separation layer to an electrochemical testing member containing an electrode and a counter-electrode, the electrode and the counter-electrode being integrated with the hybrid test strip such that the electrode and the counter-electrode are immediately adjacent to said disbursement layer, or such that a stack below said disbursement layer brings blood to the electrode and the counter-electrode; and (g) measuring an electrical property of the single blood sample using the electrode and counter-electrode wherein the electrical property is proportional to the concentration of a fourth analyte in the blood sample.