A medical device comprising: a guidewire having a proximal end and a distal end; a connection mechanism; and a self-expanding member attached to the distal end of the guidewire via the connection mechanism, the self-expanding member having a mesh configuration and comprising: a proximal portion having a first plurality of cells, the proximal portion being tapered along a longitudinal portion of its length; a distal portion having a second plurality of cells, the distal portion forming a generally tube-like configuration having a central, longitudinal axis; and a seam along a longitudinal axis of the distal portion, the seam forming two edges (22, 24) extending generally longitudinally along the self-expanding member; wherein the self-expanding member can be modified into a volume- reduced form having a generally coiled, tubular configuration for insertion within a microcatheter, the edges of the distal portion being overlapped in the volume-reduced coiled configuration such that in the volume-reduced coiled configuration the self-expanding member has multiple layers in at least one radial direction; and wherein the first plurality of cells comprises filaments having a filament thickness of between 0.045 mm and 0.080 mm, and a filament width of between 0.040 mm and 0.090 mm; wherein the second plurality of cells comprises filaments having a filament thickness of between 0.040 mm and 0.075 mm, and a filament width of between 0.038 mm and 0.082 mm; and characterized in that a plurality of filaments project distally and radially inwardly toward the central, longitudinal axis, and have a plurality of independent distal ends. a guidewire having a proximal end and a distal end; a connection mechanism; and a self-expanding member attached to the distal end of the guidewire via the connection mechanism, the self-expanding member having a mesh configuration and comprising: a proximal portion having a first plurality of cells, the proximal portion being tapered along a longitudinal portion of its length; a distal portion having a second plurality of cells, the distal portion forming a generally tube-like configuration having a central, longitudinal axis; and a seam along a longitudinal axis of the distal portion, the seam forming two edges (22, 24) extending generally longitudinally along the self-expanding member; wherein the self-expanding member can be modified into a volume- reduced form having a generally coiled, tubular configuration for insertion within a microcatheter, the edges of the distal portion being overlapped in the volume-reduced coiled configuration such that in the volume-reduced coiled configuration the self-expanding member has multiple layers in at least one radial direction; and wherein the first plurality of cells comprises filaments having a filament thickness of between 0.045 mm and 0.080 mm, and a filament width of between 0.040 mm and 0.090 mm; wherein the second plurality of cells comprises filaments having a filament thickness of between 0.040 mm and 0.075 mm, and a filament width of between 0.038 mm and 0.082 mm; and characterized in that a plurality of filaments project distally and radially inwardly toward the central, longitudinal axis, and have a plurality of independent distal ends. a proximal portion having a first plurality of cells, the proximal portion being tapered along a longitudinal portion of its length; a distal portion having a second plurality of cells, the distal portion forming a generally tube-like configuration having a central, longitudinal axis; and a seam along a longitudinal axis of the distal portion, the seam forming two edges (22, 24) extending generally longitudinally along the self-expanding member; wherein the self-expanding member can be modified into a volume- reduced form having a generally coiled, tubular configuration for insertion within a microcatheter, the edges of the distal portion being overlapped in the volume-reduced coiled configuration such that in the volume-reduced coiled configuration the self-expanding member has multiple layers in at least one radial direction; and wherein the first plurality of cells comprises filaments having a filament thickness of between 0.045 mm and 0.080 mm, and a filament width of between 0.040 mm and 0.090 mm; wherein the second plurality of cells comprises filaments having a filament thickness of between 0.040 mm and 0.075 mm, and a filament width of between 0.038 mm and 0.082 mm; and characterized in that a plurality of filaments project distally and radially inwardly toward the central, longitudinal axis, and have a plurality of independent distal ends.