A computer-implemented method of employing image registration to assess correspondence between user-selected volumetric fiducial points (230A-C) associated with preoperatively acquired volumetric image data and user-selected intraoperative fiducial points (280A-C) associated with intraoperatively acquired surface data, the method comprising: processing the volumetric image data to generate preliminary surface data characterizing an anatomical surface within the anatomical region; performing segmentation on the preliminary surface data, by employing at least one of the volumetric fiducial points associated with the preliminary surface data to obtain segmented surface data characterizing a surface region of interest within the anatomical surface; (i) employing the volumetric fiducial points and corresponding intraoperative fiducial points to register the segmented surface data to the intraoperative surface data; (ii) determining a first registration quality measure associated with a quality of the registration; repeating steps (i) and (ii) for one or more permutations of the correspondence between the intraoperative fiducial points and the volumetric fiducial points, thereby performing one or more additional registrations and obtaining one or more additional registration quality measures respectively associated with the one or more additional registrations, wherein each additional registration quality measure is associated with a different permutation of the correspondence between the volumetric fiducial points and the intraoperative fiducial points; and providing feedback associated with the registration quality measures. processing the volumetric image data to generate preliminary surface data characterizing an anatomical surface within the anatomical region; performing segmentation on the preliminary surface data, by employing at least one of the volumetric fiducial points associated with the preliminary surface data to obtain segmented surface data characterizing a surface region of interest within the anatomical surface; (i) employing the volumetric fiducial points and corresponding intraoperative fiducial points to register the segmented surface data to the intraoperative surface data; (ii) determining a first registration quality measure associated with a quality of the registration; (i) employing the volumetric fiducial points and corresponding intraoperative fiducial points to register the segmented surface data to the intraoperative surface data; (ii) determining a first registration quality measure associated with a quality of the registration; repeating steps (i) and (ii) for one or more permutations of the correspondence between the intraoperative fiducial points and the volumetric fiducial points, thereby performing one or more additional registrations and obtaining one or more additional registration quality measures respectively associated with the one or more additional registrations, wherein each additional registration quality measure is associated with a different permutation of the correspondence between the volumetric fiducial points and the intraoperative fiducial points; and providing feedback associated with the registration quality measures.