An aircraft integrated cargo fire-suppression agent distribution system, comprising: a shut-off valve operable to close such that an airflow is blocked; vehicle ventilation means comprising: a conditioned air supply source coupled to a duct system of a cargo bay through the shut-off valve; and at least one fire-suppression supply source coupled to the duct system through a fire-suppression agent flow-control valve, wherein the fire-suppressant supply source is configured to transport a fire-suppression agent into the duct system to suppress a fire within the cargo bay; and a controller coupled to a fire detector, the shut-off valve and the fire-suppression agent flow-control valve, the controller is configured to manage/control the shut-off valve and the fire-suppression agent flow-control valve and is operable to command the shut-off valve to close such that the shut-off valve changes from an open position to a closed position thereby blocking the flow of conditioned air through the duct system to restrict the conditioned air with its oxygen from the cargo bay to enhance fire suppression and substantially simultaneously to send a signal to the fire-suppression agent flow-control valve such that the fire-suppressant agent flow-control valve changes from a closed position to an open position allowing the fire-suppressant agent to flow into the duct system to distribute the fire-suppressant agent throughout the cargo bay. a shut-off valve operable to close such that an airflow is blocked; vehicle ventilation means comprising: a conditioned air supply source coupled to a duct system of a cargo bay through the shut-off valve; and at least one fire-suppression supply source coupled to the duct system through a fire-suppression agent flow-control valve, wherein the fire-suppressant supply source is configured to transport a fire-suppression agent into the duct system to suppress a fire within the cargo bay; and a controller coupled to a fire detector, the shut-off valve and the fire-suppression agent flow-control valve, the controller is configured to manage/control the shut-off valve and the fire-suppression agent flow-control valve and is operable to command the shut-off valve to close such that the shut-off valve changes from an open position to a closed position thereby blocking the flow of conditioned air through the duct system to restrict the conditioned air with its oxygen from the cargo bay to enhance fire suppression and substantially simultaneously to send a signal to the fire-suppression agent flow-control valve such that the fire-suppressant agent flow-control valve changes from a closed position to an open position allowing the fire-suppressant agent to flow into the duct system to distribute the fire-suppressant agent throughout the cargo bay. a conditioned air supply source coupled to a duct system of a cargo bay through the shut-off valve; and at least one fire-suppression supply source coupled to the duct system through a fire-suppression agent flow-control valve, wherein the fire-suppressant supply source is configured to transport a fire-suppression agent into the duct system to suppress a fire within the cargo bay; and a controller coupled to a fire detector, the shut-off valve and the fire-suppression agent flow-control valve, the controller is configured to manage/control the shut-off valve and the fire-suppression agent flow-control valve and is operable to command the shut-off valve to close such that the shut-off valve changes from an open position to a closed position thereby blocking the flow of conditioned air through the duct system to restrict the conditioned air with its oxygen from the cargo bay to enhance fire suppression and substantially simultaneously to send a signal to the fire-suppression agent flow-control valve such that the fire-suppressant agent flow-control valve changes from a closed position to an open position allowing the fire-suppressant agent to flow into the duct system to distribute the fire-suppressant agent throughout the cargo bay.