A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and tautomers or a pharmaceutically acceptable salt thereof: wherein: R 1 is H; R 2 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 3 - 8 cycloalkyl or is substituted or unsubstituted C 3 - 8 cycloalkenyl; R 5 is -S-, -S -, or -S 2 -; R 6 is substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or is substituted or unsubstituted C 6-10 aryl; R 17 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, CN, C R 19, NR 20 R 21 or hydroxyl; R 18 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, CN, C R 22, NR 23 R 24 or hydroxyl; R 7 is H, halogen, CN, substituted or unsubstituted -OC 1-6 alkyl, substituted or unsubstituted C 1-6 alkyl or is substituted or unsubstituted C 3-8 cycloalkyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, or hydroxyl; R 19 is H, OH or substituted or unsubstituted C 1-6 alkyl; R 20 is H or substituted or unsubstituted C 1-6 alkyl; R 21 is H or substituted or unsubstituted C 1-6 alkyl; R 22 is H, OH or substituted or unsubstituted C 1-6 alkyl; R 23 is H or substituted or unsubstituted C 1-6 alkyl; R 24 is H or substituted or unsubstituted C 1-6 alkyl; and wherein substituted heterocycle groups represented by R 6 are: pyridine, furan, azetidine, thiazol, thiophene, oxazol, pyrazol, isoxazole, 2-oxoindoline, 2-oxo-2,3-dihydro-1,3-benzoxazole, 2-oxo-2H-chromene, imidazole[2,1-b]thiazole, 1-H-pyrazole, indole, imidazole, quinoline, 2-thiophene, 2-benzofuran, 5-methyl-2-furan, 5-oxazolidine-2-one, pyrimidine-2,4(1 H,3 H)-dione, pyrimidine; and with the provisos that a). R 7, R 8, R 17 and R 18 cannot all be H in same time; b). when R 8 is substituted or unsubstituted C 1-6 alkyl, the alkyl group does not contain a carbonyl group directly attached to the phenyl ring; c). the compound is not of the following structures: R 1 is H; R 2 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 3 - 8 cycloalkyl or is substituted or unsubstituted C 3 - 8 cycloalkenyl; R 5 is -S-, -S -, or -S 2 -; R 6 is substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or is substituted or unsubstituted C 6-10 aryl; R 17 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, CN, C R 19, NR 20 R 21 or hydroxyl; R 18 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, CN, C R 22, NR 23 R 24 or hydroxyl; R 7 is H, halogen, CN, substituted or unsubstituted -OC 1-6 alkyl, substituted or unsubstituted C 1-6 alkyl or is substituted or unsubstituted C 3-8 cycloalkyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, substituted or unsubstituted - OC 1-6 alkyl, or hydroxyl; R 19 is H, OH or substituted or unsubstituted C 1-6 alkyl; R 20 is H or substituted or unsubstituted C 1-6 alkyl; R 21 is H or substituted or unsubstituted C 1-6 alkyl; R 22 is H, OH or substituted or unsubstituted C 1-6 alkyl; R 23 is H or substituted or unsubstituted C 1-6 alkyl; R 24 is H or substituted or unsubstituted C 1-6 alkyl; and a). R 7, R 8, R 17 and R 18 cannot all be H in same time; b). when R 8 is substituted or unsubstituted C 1-6 alkyl, the alkyl group does not contain a carbonyl group directly attached to the phenyl ring; c). the compound is not of the following structures: