mhurhangee/ep-ind-claims huggingface dataset:
An apparatus for analysing the optical properties of a free-standing sample in liquid or semi-solid form (136, 152), comprising: a housing (12, 100, 200) to receive a light source (112, 118, 156) and a detector (112, 118, 156) in predetermined positions; a cover (38, 138) on the housing (12, 100, 200), the cover being movable in a hinged manner between an open position and a closed position, the cover having an internal face which encloses a sample locus when the cover is in the closed position; wherein the sample locus is defined relative to said housing (12,100,200) and positioned such that when a light source (112,118,156) and a detector (112,118,156) are in said predetermined positions, a free-standing sample at the sample locus is subject to illumination by said light source and the detector is positioned to receive and detect light from the free-standing sample when the cover is in said closed position; a sample-receiving surface (56, 134, 154) for receiving the free-standing sample in liquid or semi-solid form, the sample-receiving surface being disposed on the internal face of the cover such that when the cover is in said open position the sample-receiving surface is exposed to and accessible by a user in a generally horizontal orientation for loading of the free-standing sample thereon; and wherein when the cover is moved to said closed position it encloses said sample locus, with the sample-receiving surface being tilted away from the horizontal during said closing movement and the free-standing sample being retained thereon by surface tension or adhesion and brought to said sample locus in an enclosed environment. a housing (12, 100, 200) to receive a light source (112, 118, 156) and a detector (112, 118, 156) in predetermined positions; a cover (38, 138) on the housing (12, 100, 200), the cover being movable in a hinged manner between an open position and a closed position, the cover having an internal face which encloses a sample locus when the cover is in the closed position; wherein the sample locus is defined relative to said housing (12,100,200) and positioned such that when a light source (112,118,156) and a detector (112,118,156) are in said predetermined positions, a free-standing sample at the sample locus is subject to illumination by said light source and the detector is positioned to receive and detect light from the free-standing sample when the cover is in said closed position; a sample-receiving surface (56, 134, 154) for receiving the free-standing sample in liquid or semi-solid form, the sample-receiving surface being disposed on the internal face of the cover such that when the cover is in said open position the sample-receiving surface is exposed to and accessible by a user in a generally horizontal orientation for loading of the free-standing sample thereon; and wherein when the cover is moved to said closed position it encloses said sample locus, with the sample-receiving surface being tilted away from the horizontal during said closing movement and the free-standing sample being retained thereon by surface tension or adhesion and brought to said sample locus in an enclosed environment.
A peptide of formula, or a pharmaceutically acceptable salt thereof: R 1 -C-R-X 1 -X 2 -P-X 3 -X 4 -X 5 -X 6 -C-R 2 wherein X 1, X 3, X 5, and X 6 is an amino acid residue selected from the group consisting of serine, alanine, valine, leucine, isoleucine and glycine; X 2 is alanine, arginine or lysine; X 4 is glutamic acid or aspartic acid; R 1 is selected from the group consisting of S, HS, GHS, PGHS, APGHS, EAPGHS, 1 SEAPGHS, SSEAPGHS, PSSEAPGHS, DPSSEAPGHS and IDPSSEAPGHS, or R is absent; and R 2 is selected from the group consisting of S, SS, SSK, SSKF, SSKFS, SSKFSW, SSKFSWD, SSKFSWDE, SSKFSWDEY, SSKFSWDEYE, SSKFSWDEYEQ, SSKFSWDEYEQY, SSKFSWDEYEQYK, SSKFSWDEYEQYKK, SSKFSWDEYEQYKKE, or R 2 is absent; and wherein the peptide of formula, or the pharmaceutically acceptable salt thereof, is a cyclic peptide formed by a disulphide bond between the two cysteine residues. X 1, X 3, X 5, and X 6 is an amino acid residue selected from the group consisting of serine, alanine, valine, leucine, isoleucine and glycine; X 2 is alanine, arginine or lysine; X 4 is glutamic acid or aspartic acid; R 1 is selected from the group consisting of S, HS, GHS, PGHS, APGHS, EAPGHS, 1 SEAPGHS, SSEAPGHS, PSSEAPGHS, DPSSEAPGHS and IDPSSEAPGHS, or R is absent; and R 2 is selected from the group consisting of S, SS, SSK, SSKF, SSKFS, SSKFSW, SSKFSWD, SSKFSWDE, SSKFSWDEY, SSKFSWDEYE, SSKFSWDEYEQ, SSKFSWDEYEQY, SSKFSWDEYEQYK, SSKFSWDEYEQYKK, SSKFSWDEYEQYKKE, or R 2 is absent; and wherein the peptide of formula, or the pharmaceutically acceptable salt thereof, is a cyclic peptide formed by a disulphide bond between the two cysteine residues.
A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein, R g is hydrogen or C 1-3 alkyl; and R h and R f are independently hydrogen or C 1-3 alkyl. or a pharmaceutically acceptable salt thereof, wherein, R g is hydrogen or C 1-3 alkyl; and R h and R f are independently hydrogen or C 1-3 alkyl.
A method of diagnosing in a mammal an autoimmune neurological disorder selected from the group comprising limbic encephalitis, Morvan's syndrome, and neuromyotonia comprising detecting, in a bodily fluid sample from the mammal, autoantibodies to an epitope of at least one Kvl-complex protein, wherein the Kvl-complex protein comprises at least one of CASPR2 (contactin associated protein 2), Lgil (leucine-rich glioma inactivated gene 1) and TAG1 (transient axonal glycoprotein-1); wherein the method comprises the steps of a) contacting the bodily fluid with the at least one Kvl-complex protein; and b) detecting any autoantibody-antigen complexes formed between the at least one Kvl-complex protein and autoantibodies present in the bodily fluid, wherein presence of said complex is indicative of an autoimmune neurological disorder selected from the group comprising limbic encephalitis, Morvan's syndrome, and neuromyotonia.
A crystal of -2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole wherein the powder X-ray diffraction analysis pattern has characteristic peaks at interplanar spacings (d) of 10.06±0.2, 8.70±0.2, 6.57±0.2, 5.59±0.2 and 4.00±0.2 Angstrom.
A method for the production of methionine in a fermentative process comprising the following steps: - culturing a modified microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur, wherein the expression of the methionine repressor encoded by the metJ gene is attenuated in said modified microorganism, and - recovering methionine from the culture medium, wherein compared to a non-modified method, the method has been modified to present an increased methionine/ carbon source yield by limiting growth and biomass production of the modified microorganism, by limiting or starving the microorganism for phosphate in the culture medium. - culturing a modified microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur, wherein the expression of the methionine repressor encoded by the metJ gene is attenuated in said modified microorganism, and - recovering methionine from the culture medium,
A radio receiver circuit configurable to operate in a carrier-aggregation, CA, mode, wherein the radio receiver circuit is to receive a plurality of component carriers, CCs, (6, 8), and in a non-CA mode, wherein the radio receiver circuit is to receive a single CC, comprising: a first receive path arranged to be operatively connected to an antenna; a second receive path arranged to be operatively connected to the same antenna; and a control unit operatively connected to the first receive path and the second receive path; wherein the control unit is adapted to, in the CA mode, control the first receive path to receive a first CC of said plurality of CCs and control the second receive path to receive a second CC, separate from the first CC, of said plurality of CCs; and the control unit is adapted to, in the non-CA mode, selectively control the first receive path and the second receive path to both receive the same single CC. a first receive path arranged to be operatively connected to an antenna; a second receive path arranged to be operatively connected to the same antenna; and a control unit operatively connected to the first receive path and the second receive path; wherein the control unit is adapted to, in the CA mode, control the first receive path to receive a first CC of said plurality of CCs and control the second receive path to receive a second CC, separate from the first CC, of said plurality of CCs; and the control unit is adapted to, in the non-CA mode, selectively control the first receive path and the second receive path to both receive the same single CC.
A fuel cell system comprising: a fuel cell configured to cause reactant gas to be electrochemically reacted to generate electrical power when the reactant gas is supplied to the fuel cell; power consuming means operable to consume electrical power generated by the fuel cell, the power consuming means including a reactant gas supply means configured to supply the reactant gas to the fuel cell and a heating means configured to heat coolant supplied to the fuel cell; and a control means for controlling operation of the fuel cell; wherein during a warm-up operation, the control means causes the reactant gas supply means to start a flow of the reactant gas and to increase the flow of the reactant gas over time, such that the reactant gas supply means starts to consume power and consumes increased power over time; and characterized in that after the reactant gas supply means starts to consume a predetermined power increased by the increased flow of the reactant gas, the control means causes the heating means to start heating the coolant supplied to the fuel cell such that the heating means consumes power, wherein the control means is adapted to calculate a target generating power (Lc) over time, to cause the power generation of the fuel cell on the basis of the target generating power (Lc), and to increase the rotational speed of the reactant gas supply means. a fuel cell configured to cause reactant gas to be electrochemically reacted to generate electrical power when the reactant gas is supplied to the fuel cell; power consuming means operable to consume electrical power generated by the fuel cell, the power consuming means including a reactant gas supply means configured to supply the reactant gas to the fuel cell and a heating means configured to heat coolant supplied to the fuel cell; and a control means for controlling operation of the fuel cell; wherein during a warm-up operation, the control means causes the reactant gas supply means to start a flow of the reactant gas and to increase the flow of the reactant gas over time, such that the reactant gas supply means starts to consume power and consumes increased power over time; and characterized in that after the reactant gas supply means starts to consume a predetermined power increased by the increased flow of the reactant gas, the control means causes the heating means to start heating the coolant supplied to the fuel cell such that the heating means consumes power, wherein the control means is adapted to calculate a target generating power (Lc) over time, to cause the power generation of the fuel cell on the basis of the target generating power (Lc), and to increase the rotational speed of the reactant gas supply means.
A method for in vitro diagnosis and/or in vitro therapy tracking of an infection and/or disease, in particular infectious disease, and/or tumour disease and/or autoimmune disease and/or allergy and/or for vaccination monitoring and/or for the detection of cross-protectivity, wherein the method includes the following steps: (a) providing - a sample which contains antibody-secreting cells, - a carrier with a surface on which anti-Ig antibodies are immobilised, and - a plurality of different antigens from various infectious pathogens and/or various tumour antigens and/or various autoimmune antigens and/or various allergens, wherein the antigens are in each case differently labelled, (b) contacting the carrier surface with the plurality of different antigens and the sample under conditions which are suitable for the antibody-secreting cells to be stimulated by the antigens and for antibodies which are produced by the antibody-secreting cells to bind to the immobilised anti-Ig antibodies of the carrier surface and for the antigens to bind to antibodies which are specific for the antigens, and (c) detecting labelled antigens which have been captured on the carrier surface, whereby the presence or absence of antibody-secreting cells contained in the sample which are specific for the antigens is detected. (a) providing - a sample which contains antibody-secreting cells, - a carrier with a surface on which anti-Ig antibodies are immobilised, and - a plurality of different antigens from various infectious pathogens and/or various tumour antigens and/or various autoimmune antigens and/or various allergens, wherein the antigens are in each case differently labelled, - a sample which contains antibody-secreting cells, - a carrier with a surface on which anti-Ig antibodies are immobilised, and - a plurality of different antigens from various infectious pathogens and/or various tumour antigens and/or various autoimmune antigens and/or various allergens, wherein the antigens are in each case differently labelled, (b) contacting the carrier surface with the plurality of different antigens and the sample under conditions which are suitable for the antibody-secreting cells to be stimulated by the antigens and for antibodies which are produced by the antibody-secreting cells to bind to the immobilised anti-Ig antibodies of the carrier surface and for the antigens to bind to antibodies which are specific for the antigens, and (c) detecting labelled antigens which have been captured on the carrier surface, whereby the presence or absence of antibody-secreting cells contained in the sample which are specific for the antigens is detected.
An ultrasound transducer, comprising: a transducer array having a first side and a second side and comprising a plurality of transducer elements; isolation cuts provided across a plurality of transducer elements of the transducer array; one or more ground electrodes disposed on the first side of the transducer array as well as on a portion of the second side of the transducer array; one or more signal electrodes disposed on the second side of the transducer array in between the isolation cuts; an acoustic backing structure operatively coupled to the plurality of transducer elements of the transducer array, wherein the acoustic backing structure comprises a curved surface; and a plurality of electrical traces comprising a plurality of signal traces coupled to respective signal electrodes of the one or more signal electrodes, and a plurality of ground traces coupled to respective ground electrodes of the one or more ground electrodes, the plurality of electrical traces being routed on a surface of the acoustic backing structure and disposed directly on the surface of the acoustic backing structure. a transducer array having a first side and a second side and comprising a plurality of transducer elements; isolation cuts provided across a plurality of transducer elements of the transducer array; one or more ground electrodes disposed on the first side of the transducer array as well as on a portion of the second side of the transducer array; one or more signal electrodes disposed on the second side of the transducer array in between the isolation cuts; an acoustic backing structure operatively coupled to the plurality of transducer elements of the transducer array, wherein the acoustic backing structure comprises a curved surface; and a plurality of electrical traces comprising a plurality of signal traces coupled to respective signal electrodes of the one or more signal electrodes, and a plurality of ground traces coupled to respective ground electrodes of the one or more ground electrodes, the plurality of electrical traces being routed on a surface of the acoustic backing structure and disposed directly on the surface of the acoustic backing structure.
A clutch mechanism designed to be installed between an engine and a motor vehicle transmission, wherein the clutch mechanism comprises: - at least one clutch (100, 200) rotating around an axis 0; - a control system of the clutch (100, 200) comprising: ∘ a case; and ∘ at least one annular piston (320, 330) arranged to be displaced axially relative to the case in order to engage or disengage the clutch (100, 200) by way of at least one transmission bearing (140, 240); - a clutch support arranged to support the clutch (100, 200) radially by way of a support bearing, wherein the clutch support is situated in a position axially intermediate between the control system and an output hub (120, 220) of the clutch mechanism: - at least one cooling duct arranged to make a cooling fluid circulate toward the clutch (100, 200), wherein each cooling duct comprises an axially extending part and at least one radially extending part; characterized in that the axially extending part of each cooling duct is situated radially between a transmission shaft and an interior face of the clutch support, and at least one radially extending part of each cooling duct is situated axially between the support bearing and the output hub (120, 220) and in that the radially extending part is formed by a bore passing from one side to the other and made in the clutch support. - at least one clutch (100, 200) rotating around an axis 0; - a control system of the clutch (100, 200) comprising: ∘ a case; and ∘ at least one annular piston (320, 330) arranged to be displaced axially relative to the case in order to engage or disengage the clutch (100, 200) by way of at least one transmission bearing (140, 240); ∘ a case; and ∘ at least one annular piston (320, 330) arranged to be displaced axially relative to the case in order to engage or disengage the clutch (100, 200) by way of at least one transmission bearing (140, 240); - a clutch support arranged to support the clutch (100, 200) radially by way of a support bearing, wherein the clutch support is situated in a position axially intermediate between the control system and an output hub (120, 220) of the clutch mechanism: - at least one cooling duct arranged to make a cooling fluid circulate toward the clutch (100, 200), wherein each cooling duct comprises an axially extending part and at least one radially extending part;
A lighting module comprising: an optical plate; a base frame comprising a central frame disposed on the optical plate, a first frame coupled to the central frame, and a second frame coupled to the first frame; a side frame comprising a first side frame coupled to the second frame of the base frame and a second side frame coupled to the optical plate; a light source comprising a substrate disposed on the second side frame and a light emitter disposed on the substrate, wherein the second frame is disposed on the light source, and wherein the second frame comprises an inner surface reflecting light from the light emitter to at least one of the first frame and the central frame, Characterized in that: a cross sectional shape of the inner surface of the second frame has any one of a parabolic shape, a hyperbolic shape and an elliptical shape, and the light emitter is disposed at a position corresponding to the focus of the inner surface of the second frame. an optical plate; a base frame comprising a central frame disposed on the optical plate, a first frame coupled to the central frame, and a second frame coupled to the first frame; a side frame comprising a first side frame coupled to the second frame of the base frame and a second side frame coupled to the optical plate; a light source comprising a substrate disposed on the second side frame and a light emitter disposed on the substrate, wherein the second frame is disposed on the light source, and wherein the second frame comprises an inner surface reflecting light from the light emitter to at least one of the first frame and the central frame, Characterized in that: a cross sectional shape of the inner surface of the second frame has any one of a parabolic shape, a hyperbolic shape and an elliptical shape, and the light emitter is disposed at a position corresponding to the focus of the inner surface of the second frame. a cross sectional shape of the inner surface of the second frame has any one of a parabolic shape, a hyperbolic shape and an elliptical shape, and the light emitter is disposed at a position corresponding to the focus of the inner surface of the second frame.
A process for making a polyisocyanurate- polyurethane comprising rigid foam (PIR-PUR), having a density <60 kg/m 3, said process comprising combining and mixing at an isocyanate index of at least more than 100, preferably 180 or higher, more preferably higher than 250: a) a polyisocyanate composition comprising one or more polyisocyanate compounds; b) an isocyanate-reactive composition comprising one or more isocyanate reactive compounds; c) a trimerization catalyst composition comprising at least one trimerization catalyst compound selected from one or more organic alkoxides corresponding to the formula: (R-O -) x M +x Wherein - R is an organic group which is selected from an hydrocarbyl group wherein the hydrocarbyl groups has 1-4 carbon atoms, - x is a number being defined by the oxidation state of M - M is selected from an alkali metal ion, an earth alkali metal ion, a transition metal ion such as Ti or a quaternary ammonium ion d) optionally one or more surfactants, one or more flame retardants, water, one or more antioxidants, one or more auxiliary blowing agents, one or more urethane catalysts, one or more auxiliary trimerisation catalysts, or combinations thereof a) a polyisocyanate composition comprising one or more polyisocyanate compounds; b) an isocyanate-reactive composition comprising one or more isocyanate reactive compounds; c) a trimerization catalyst composition comprising at least one trimerization catalyst compound selected from one or more organic alkoxides corresponding to the formula: (R-O -) x M +x Wherein - R is an organic group which is selected from an hydrocarbyl group wherein the hydrocarbyl groups has 1-4 carbon atoms, - x is a number being defined by the oxidation state of M - M is selected from an alkali metal ion, an earth alkali metal ion, a transition metal ion such as Ti or a quaternary ammonium ion - R is an organic group which is selected from an hydrocarbyl group wherein the hydrocarbyl groups has 1-4 carbon atoms, - x is a number being defined by the oxidation state of M - M is selected from an alkali metal ion, an earth alkali metal ion, a transition metal ion such as Ti or a quaternary ammonium ion d) optionally one or more surfactants, one or more flame retardants, water, one or more antioxidants, one or more auxiliary blowing agents, one or more urethane catalysts, one or more auxiliary trimerisation catalysts, or combinations thereof