A patient interface comprising: a plenum chamber pressurisable to a therapeutic pressure of at least 6 cmH 2 O above ambient air pressure throughout a patient's respiratory cycle in use, the plenum chamber comprising: one or more walls; a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, the seal-forming structure comprising a nasal portion having at least one nasal hole configured to deliver a flow of air at said therapeutic pressure to an entrance to the patient's nares in use, the seal-forming structure comprising an oral portion having an oral hole configured to deliver the flow of air at said therapeutic pressure to an entrance to the patient's mouth in use, the seal-forming structure constructed and arranged to maintain said therapeutic pressure in the plenum chamber throughout the patient's respiratory cycle in use; and one or more plenum chamber inlet ports sized and structured to receive a flow of air at the therapeutic pressure for breathing by the patient throughout the patient's respiratory cycle in use; and a positioning and stabilising structure configured to generate a force to hold the seal-forming structure in a therapeutically effective position on the patient's head, wherein the seal-forming structure comprises an oral hole peripheral portion at a periphery of the oral hole, and posterior-facing lateral portions that form lateral peripheral support portions, with the lateral peripheral support portion being provided at opposite lateral sides of the oral hole and being adjacent to the oral hole peripheral portion, wherein each of the posterior-facing lateral portions extends medially towards the most lateral edges of the oral hole to provide the lateral peripheral support portions, and wherein the lateral peripheral support portions are stiffer than the oral hole peripheral portion. a plenum chamber pressurisable to a therapeutic pressure of at least 6 cmH 2 O above ambient air pressure throughout a patient's respiratory cycle in use, the plenum chamber comprising: one or more walls; a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, the seal-forming structure comprising a nasal portion having at least one nasal hole configured to deliver a flow of air at said therapeutic pressure to an entrance to the patient's nares in use, the seal-forming structure comprising an oral portion having an oral hole configured to deliver the flow of air at said therapeutic pressure to an entrance to the patient's mouth in use, the seal-forming structure constructed and arranged to maintain said therapeutic pressure in the plenum chamber throughout the patient's respiratory cycle in use; and one or more plenum chamber inlet ports sized and structured to receive a flow of air at the therapeutic pressure for breathing by the patient throughout the patient's respiratory cycle in use; and one or more walls; a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, the seal-forming structure comprising a nasal portion having at least one nasal hole configured to deliver a flow of air at said therapeutic pressure to an entrance to the patient's nares in use, the seal-forming structure comprising an oral portion having an oral hole configured to deliver the flow of air at said therapeutic pressure to an entrance to the patient's mouth in use, the seal-forming structure constructed and arranged to maintain said therapeutic pressure in the plenum chamber throughout the patient's respiratory cycle in use; and one or more plenum chamber inlet ports sized and structured to receive a flow of air at the therapeutic pressure for breathing by the patient throughout the patient's respiratory cycle in use; and a positioning and stabilising structure configured to generate a force to hold the seal-forming structure in a therapeutically effective position on the patient's head, wherein the seal-forming structure comprises an oral hole peripheral portion at a periphery of the oral hole, and posterior-facing lateral portions that form lateral peripheral support portions, with the lateral peripheral support portion being provided at opposite lateral sides of the oral hole and being adjacent to the oral hole peripheral portion, wherein each of the posterior-facing lateral portions extends medially towards the most lateral edges of the oral hole to provide the lateral peripheral support portions, and wherein the lateral peripheral support portions are stiffer than the oral hole peripheral portion.