mhurhangee/ep-ind-claims huggingface dataset:
A compound represented by formula, a pharmaceutically acceptable salt thereof or a tautomer thereof: wherein, n is selected form 0, 1 or 2; r is selected from 0, 1, 2 or 3; m is selected from 0 or 1; when m is 0, then is H; ring A is selected from phenyl or 5-6 membered heteroaryl; L is selected from a single bond, -S(=O)-, -S(=O) 2 -, -C(=O)-, -NH-, -NH-C(=O)-, -NH-C(=O)-O-, -NH-S(=O) 2 -, -NH-S(=O)- and -NH-C(=O)-NH-, wherein the -NH-, -NH-C(=O)-, -NH-C(=O)-O-, -NH-S(=O) 2 -, -NH-S(=O)- and -NH-C(=O)-NH- are each optionally substituted by 1, 2 or 3 R; Ri is selected from H, NH 2, C 1-6 alkyl, 3-6 membered heterocycloalkyl, C 3-6 cycloalkyl and C 1-3 heteroalkyl, wherein the NH 2, C 1-6 alkyl, 3-6 membered heterocycloalkyl, C 3-6 cycloalkyl and C 1-3 heteroalkyl are each optionally substituted by 1, 2 or 3 R; R 2 is selected from H, C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl and 5-6 membered heterocycloalkyl, wherein the C 1-6 alkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl and 5-6 membered heterocycloalkyl are each optionally substituted by 1, 2 or 3 R; R 3 is selected from H, F, Cl, Br, I, C 1-3 alkyl, C 1-3 alkoxy, C 1-4 alkynyl, C 1-4 alkenyl and phenyl, wherein the C 1-3 alkyl, C 1-3 alkoxy, C 1-4 alkynyl, C 1-4 alkenyl and phenyl are each optionally substituted by 1, 2 or 3 R; R 4 and Rs are independently selected from H, F, Cl, Br, I, NH 2, OH, C 1-6 alkyl and C 1-3 alkoxy, wherein the C 1-6 alkyl and C 1-3 alkoxy are each optionally substituted by 1, 2 or 3 R; or, R 3 and R 4 are linked together to form a 5-7 membered cycloalkyl, 5-7 membered heterocycloalkyl, 5-7 membered aryl or 5-7 membered heteroaryl; R 6 and R 7 are independently selected from H, F, Cl, Br, I, CH 3, Et, CH 3 -O- and CH 3 -CH 2 -O-; R is selected from F, Cl, Br, I, OH, NH 2, C 1-3 alkyl and C 1-3 heteroalkyl, wherein the NH 2, C 1-3 alkyl and C 1-3 heteroalkyl are each optionally substituted by 1, 2 or 3 R'; R' is selected from F, Cl, Br, I, NH 2 or C 1-3 alkyl; each of the "hetero" in the 5-6 membered heteroaryl, 5-6 membered heterocycloalkyl, 3-6 membered heterocycloalkyl, C 1-3 heteroalkyl, 5-7 membered heterocycloalkyl, 5-7 membered heterocycloalkyl, 5-7 membered aryl and 5-7 membered heteroaryl is independently selected from -NH-, N, -O-, -S(=O) 2 -, -S(=O) 2 -NH-, -NH-S(=O) 2 -NH-, - C(=O)-NH-, -S(=O)-, -C(=O)-, -S(=O)-NH- and -O-C(=O)-NH-; in any of the above cases, the number of the heteroatom or heteroatomic group is independently selected from 1, 2, 3 or 4.
An antimicrobial composition comprising ingredients selected from the group consisting of: nona-2,6-dien-1-ol in combination with at least one ingredient selected from the group consisting of 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol and 2-isopropyl-5-methylphenol, wherein the ingredients are present in an amount sufficient to provide an antimicrobial effect, wherein the antimicrobial effect is an inhibition of growth of a bacterial strain selected from the group consisting of: C. xerosis, S. aureus and E. coli, wherein the amount sufficient of the nona-2,6-dien-1-ol is from 75 to 300 ppm, the amount sufficient of the 3-neopentylpyridine is from 75 to 150 ppm, the amount sufficient of the terpineol is from 300 to 600 ppm, the amount sufficient of the 2-methylhexan-3-one oxime is from 1000 to 1200 ppm, and the amount sufficient of the 2-isopropyl-5-methylphenol is from 100 to 200 ppm.
An isolated variant Factor VII polypeptide produced in a mammalian host cell, the polypeptide comprising an amino acid sequence at least 90% identical to the amino acid sequence of the entire length of wild type human Factor VII (SEQ ID NO: 16) and being modified from SEQ ID NO: 16 by having at least two sequence alterations relative to the amino acid sequence of SEQ ID NO: 16, wherein the at least two sequence alterations are a glutamine residue substituted for the proline residue in position 10, and a glutamic acid residue substituted for the lysine residue in position 32, and the polypeptide has a ratio of moles of conjugated sialic acid to moles of N-linked glycan between 0 and 2.0.
Method for monitoring a sliding bearing having a shaft mounted therein, in particular a shaft rotating therein, for at least one mixed friction event (a, b, c, d), wherein at least one time-dependent structure-borne sound signal is picked up from the sliding bearing by at least one structure-borne sound sensor, in particular precisely one structure-borne sound sensor, characterized by a) filtering of the structure-borne sound signal, b) subsequent calculation of an envelope curve for the filtered structure-borne sound signal, c) subsequent smoothing of the envelope curve, and d) combination of the data for the smoothed envelope curve with a rotational angle signal dependent on the revolution of the shaft in the sliding bearing, wherein the rotational angle signal is determined and/or generated by pattern recognition or a reference pulse, in particular a magnetic reference pulse, by means of an incremental encoder, e) calculation of at least one maximum from the smoothed envelope curve, which is correlated with the at least one mixed friction event (a, b, c, d), from the combined data from step d) for determining an angle specification for the at least one mixed friction event (a, b, c, d) at the circumference of the sliding bearing. a) filtering of the structure-borne sound signal, b) subsequent calculation of an envelope curve for the filtered structure-borne sound signal, c) subsequent smoothing of the envelope curve, and d) combination of the data for the smoothed envelope curve with a rotational angle signal dependent on the revolution of the shaft in the sliding bearing, wherein the rotational angle signal is determined and/or generated by pattern recognition or a reference pulse, in particular a magnetic reference pulse, by means of an incremental encoder, e) calculation of at least one maximum from the smoothed envelope curve, which is correlated with the at least one mixed friction event (a, b, c, d), from the combined data from step d) for determining an angle specification for the at least one mixed friction event (a, b, c, d) at the circumference of the sliding bearing.
A communication method comprising: providing, between a gateway and a policy server, a first communications link using a first protocol, and a second communications link using a second protocol distinct from the first protocol; receiving a request for a service at the gateway from a client device having a unique identifier; extracting, at a deep packet inspection engine of the gateway, identifying information from the request, and providing the identifying information to an application function engine of the gateway; determining, at the application function engine using the identifying information, service characteristics associated with said request, including a service identifier; sending, from said application function engine at the gateway to the policy server, said unique identifier and said service characteristics over said second communications link; in response to said sending, receiving a service profile at a policy enforcement engine of said gateway from said policy server over said first communications link; denying said request at said policy enforcement engine if said service profile does not permit access of said service by said client device; fulfilling said request at said policy enforcement engine by permitting said client device to connect to said service; said fulfilling performed in accordance with said service policy if said service profile permits access to said service by said client device. providing, between a gateway and a policy server, a first communications link using a first protocol, and a second communications link using a second protocol distinct from the first protocol; receiving a request for a service at the gateway from a client device having a unique identifier; extracting, at a deep packet inspection engine of the gateway, identifying information from the request, and providing the identifying information to an application function engine of the gateway; determining, at the application function engine using the identifying information, service characteristics associated with said request, including a service identifier; sending, from said application function engine at the gateway to the policy server, said unique identifier and said service characteristics over said second communications link; in response to said sending, receiving a service profile at a policy enforcement engine of said gateway from said policy server over said first communications link; denying said request at said policy enforcement engine if said service profile does not permit access of said service by said client device; fulfilling said request at said policy enforcement engine by permitting said client device to connect to said service; said fulfilling performed in accordance with said service policy if said service profile permits access to said service by said client device.
A process for making one or more isohexides, comprising: dehydrating one or more hexitols in the presence of an acid catalyst to form a crude dehydration product mixture; adding one or more antioxidants to the crude dehydration product mixture prior to the distillation of the crude dehydration product mixture; and further processing the crude dehydration product mixture containing the one or more antioxidants by distillation to yield a product enriched in one or more isohexides compared to the crude dehydration product mixture, wherein at least one of the one or more antioxidant additives possesses sufficient volatility to at least partially co-distill with the isohexide on a distillation of the composition and is soluble in the isohexide under room temperature conditions. dehydrating one or more hexitols in the presence of an acid catalyst to form a crude dehydration product mixture; adding one or more antioxidants to the crude dehydration product mixture prior to the distillation of the crude dehydration product mixture; and further processing the crude dehydration product mixture containing the one or more antioxidants by distillation to yield a product enriched in one or more isohexides compared to the crude dehydration product mixture, wherein at least one of the one or more antioxidant additives possesses sufficient volatility to at least partially co-distill with the isohexide on a distillation of the composition and is soluble in the isohexide under room temperature conditions.
A foldable mobile device, comprising: a housing having a first portion and a second portion foldable around a folding axis of the housing to allow a folded state of the device; an antenna operatively assembled to the housing; and a display mounted on a front side of the first portion and a front side of the second portion, wherein the first portion comprises a first plate configured on a back side of the first portion opposite to the front side of the first portion and a first contacting structure, wherein the second portion comprises a second plate configured on a back side of the second portion opposite to the front side of the second portion, and wherein when the mobile device operates in the folded state, the first plate and the second plate are electrically conductively coupled with each other via the first contacting structure; wherein the first plate and the second plate are made of conductive material; and wherein the first plate covers substantially the back side of the first portion and the second plate covers substantially the back side of the second portion. a housing having a first portion and a second portion foldable around a folding axis of the housing to allow a folded state of the device; an antenna operatively assembled to the housing; and a display mounted on a front side of the first portion and a front side of the second portion, wherein the first portion comprises a first plate configured on a back side of the first portion opposite to the front side of the first portion and a first contacting structure, wherein the second portion comprises a second plate configured on a back side of the second portion opposite to the front side of the second portion, and wherein when the mobile device operates in the folded state, the first plate and the second plate are electrically conductively coupled with each other via the first contacting structure; wherein the first plate and the second plate are made of conductive material; and wherein the first plate covers substantially the back side of the first portion and the second plate covers substantially the back side of the second portion.
A method to reduce spray drift during the application of a pesticide which comprises incorporating into the pesticidal spray from 0.01 to 5 percent vol/vol of a self-emulsifiable ester or mixture thereof, in which the self-emulsifiable ester is trimer acid based self-emulsifiable esters produced by the polymerization of oleic and linoleic acids having a C 54 lipophilic backbone and an ester portion of the molecule containing both nonionic and anionic surfactant functionality; esters prepared by esterification of ethoxylated trimethylolpropane by fatty acids and dicarboxylic acid anhydrides; esters derived from high molecular weight dibasic acids, polyoxyalkylene glycols and monofunctional aliphatic alcohols; self emulsifying ester compounds prepared by reacting an ethoxylated trimethylol propane with a carboxylic acid or a reactive derivative thereof; succinate triglyceride oil derived from maleating triglyceride oil from a plant or land animal; ethoxylated fatty acid esters; alkoxylate esters prepared by reacting an alcohol with ethylene oxide and propylene oxide and/or butylene oxide and capping the resulting alkoxylate with an alkanoic or aromatic acid; and alkoxylated triglycerides.
A method in a touch-sensing apparatus, said apparatus comprising a light transmissive panel that defines a touch surface and an opposite surface, a light source arrangement (2; 8) for providing sheets of light inside the panel, wherein said sheets comprise light that propagates by internal reflection between the touch surface and the opposite surface, and a light sensor arrangement (3; 9) for measuring transmitted light energy, wherein the light source arrangement (2; 8) and the light sensor arrangement (3; 9) are arranged to define a grid of detection lines D j on the touch surface, each detection line D j representing a light path across the touch surface from the light source arrangement (2; 8) to the light sensor arrangement (3; 9), and wherein the touch-sensing apparatus is configured such that one or more objects touching the touch surface causes a local attenuation in said grid of detection lines D j, said method comprising the steps of: obtaining an output vector d containing signal values d m indicative of light received by the light sensor arrangement (3; 9) on a set of detection lines D j; representing a two-dimensional attenuation field on the touch surface by a plurality of two-dimensional basis functions f v, wherein each basis function f v defines an attenuation strength within its two-dimensional extent and wherein each basis function partially overlaps with a plurality of other basis functions; and calculating an estimated attenuation field, based on a mapping of said set of detection lines D j to each basis function f v, by optimizing at least one of the attenuation strength and the location of each basis function f v such that the estimated attenuation field yields the output vector d; and processing the estimated attenuation field for extraction of touch data relating to said one or more objects. obtaining an output vector d containing signal values d m indicative of light received by the light sensor arrangement (3; 9) on a set of detection lines D j; representing a two-dimensional attenuation field on the touch surface by a plurality of two-dimensional basis functions f v, wherein each basis function f v defines an attenuation strength within its two-dimensional extent and wherein each basis function partially overlaps with a plurality of other basis functions; and calculating an estimated attenuation field, based on a mapping of said set of detection lines D j to each basis function f v, by optimizing at least one of the attenuation strength and the location of each basis function f v such that the estimated attenuation field yields the output vector d; and processing the estimated attenuation field for extraction of touch data relating to said one or more objects.
An anti-inflammatory composition comprising a Stauntonia Hexaphylla extract as an active ingredient, wherein the Stauntonia Hexaphylla extract is a fraction obtained by fractionating a Stauntonia Hexaphylla leaf hot water extract, extracted at 50 °C to 150 °C, with ethyl acetate or chloroform as a fractionation solvent.
A cutting insert comprising a first end surface, a second end surface opposing the first end surface, and a peripheral side surface connecting the first end surface and the second end surface, and having an axis defined so as to penetrate the first end surface and the second end surface, wherein: a mounting hole is formed so as to penetrate the first end surface and the second end surface; an intersecting edge between the first end surface and the peripheral side surface is provided with at least a cutting edge; the second end surface has at least one inclined part; wherein when a virtual plane which is substantially perpendicular to the axis and passes through any point of the cutting edge is defined, the inclined part is inclined so as to be more distant from the virtual plane, heading from the peripheral side surface to a virtual plane, which includes the axis and extends in a direction substantially parallel to the peripheral side surface which corresponds to the cutting edge; characterized in that a projected part projected in a direction along the axis is formed between the mounting hole and the inclined part, and the projected part is formed around the entire circumference of the mounting hole. a mounting hole is formed so as to penetrate the first end surface and the second end surface; an intersecting edge between the first end surface and the peripheral side surface is provided with at least a cutting edge; the second end surface has at least one inclined part; wherein when a virtual plane which is substantially perpendicular to the axis and passes through any point of the cutting edge is defined, the inclined part is inclined so as to be more distant from the virtual plane, heading from the peripheral side surface to a virtual plane, which includes the axis and extends in a direction substantially parallel to the peripheral side surface which corresponds to the cutting edge; characterized in that a projected part projected in a direction along the axis is formed between the mounting hole and the inclined part, and the projected part is formed around the entire circumference of the mounting hole.
A breathing apparatus for artificially ventilating a patient, wherein the breathing apparatus has at least one overpressure unit, in particular a compressor for respiratory gas, for providing a respiratory gas pressure flow in or for an inhalation channel, and one or more electronic control means controlling the overpressure unit, wherein the control means is set up, in terms of programming and/or circuitry, to connect the overpressure unit with its respiratory gas pressure flow selectively, fluidically, to the inhalation channel at at least one previously determined time and/or trigger condition and/or separate it from the inhalation channel, characterised in that in addition to the continuous overpressure unit, a further overpressure unit is arranged as pulsating overpressure unit which preferably is or can be controlled by the control means for providing a respiratory gas pressure flow which alternates between a higher pressure range making possible overpressure inhalation or hyperventilation and a lower pressure range making possible expiration or exhalation. the control means is set up, in terms of programming and/or circuitry, to connect the overpressure unit with its respiratory gas pressure flow selectively, fluidically, to the inhalation channel at at least one previously determined time and/or trigger condition and/or separate it from the inhalation channel, characterised in that in addition to the continuous overpressure unit, a further overpressure unit is arranged as pulsating overpressure unit which preferably is or can be controlled by the control means for providing a respiratory gas pressure flow which alternates between a higher pressure range making possible overpressure inhalation or hyperventilation and a lower pressure range making possible expiration or exhalation.
Safety arming system for an explosive charge, comprising: - a sleeve that carries a detonator for actuating said explosive charge and which, in a cylinder, is able to move between a fixed safety position in which the detonator is away from said explosive charge, and a fixed arming position in which said detonator is aligned with said explosive charge, - an arming actuator for moving said sleeve from said fixed safety position to said fixed arming position, and - a disarming actuator arranged opposite said arming actuator with respect to said cylinder, able to return said sleeve from said fixed arming position to said fixed safety position; and - inside said cylinder, a jacket: • inside which said sleeve is able to move, under the action of said arming actuator, from said fixed safety position to said fixed arming position until it is secured to said jacket, in said fixed arming position, by virtue of spontaneous securing means, and • which is able, under the action of said disarming actuator, to slide in said cylinder in order to return said sleeve, which has thus become spontaneously fixed thereto, from said fixed arming position to said fixed safety position. - a sleeve that carries a detonator for actuating said explosive charge and which, in a cylinder, is able to move between a fixed safety position in which the detonator is away from said explosive charge, and a fixed arming position in which said detonator is aligned with said explosive charge, - an arming actuator for moving said sleeve from said fixed safety position to said fixed arming position, and - a disarming actuator arranged opposite said arming actuator with respect to said cylinder, able to return said sleeve from said fixed arming position to said fixed safety position; and - inside said cylinder, a jacket: • inside which said sleeve is able to move, under the action of said arming actuator, from said fixed safety position to said fixed arming position until it is secured to said jacket, in said fixed arming position, by virtue of spontaneous securing means, and • which is able, under the action of said disarming actuator, to slide in said cylinder in order to return said sleeve, which has thus become spontaneously fixed thereto, from said fixed arming position to said fixed safety position. • inside which said sleeve is able to move, under the action of said arming actuator, from said fixed safety position to said fixed arming position until it is secured to said jacket, in said fixed arming position, by virtue of spontaneous securing means, and • which is able, under the action of said disarming actuator, to slide in said cylinder in order to return said sleeve, which has thus become spontaneously fixed thereto, from said fixed arming position to said fixed safety position.