Device for filling and priming syringes, the device comprising: - a support base; - an engagement seat defined on the support base in order to receive the rear end of the syringe barrel of a syringe provided with a sliding plunger; - engaging means defined at the engagement seat and adapted to cooperate with the syringe barrel for firmly holding the syringe associated to the engagement seat; - a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat and is adapted to generate an under-pressure in the volume comprised between the plunger of the syringe and the engagement seat when the syringe is firmly engaged in the engagement seat; - a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat and is adapted to generate an over-pressure in the volume comprised between the plunger of the syringe and the engagement seat when the syringe is firmly engaged in the engagement seat the device being characterized by - a first electrically operated valve associated to the discharge opening of the first pump or compressor, said first electrically operated valve being a normally open type valve or normally closed type valve, i.e. capable of allowing priming of air from said discharge opening when said valve is not excited or is excited, respectively; - a second electrically operated valve associated to the suction opening of the second pump or compressor, said second electrically operated valve being a normally open type valve or normally closed type valve, i.e. capable of allowing suction of air from said suction opening when said valve is not excited or is excited, respectively. - a support base; - an engagement seat defined on the support base in order to receive the rear end of the syringe barrel of a syringe provided with a sliding plunger; - engaging means defined at the engagement seat and adapted to cooperate with the syringe barrel for firmly holding the syringe associated to the engagement seat; - a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat and is adapted to generate an under-pressure in the volume comprised between the plunger of the syringe and the engagement seat when the syringe is firmly engaged in the engagement seat; - a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat and is adapted to generate an over-pressure in the volume comprised between the plunger of the syringe and the engagement seat when the syringe is firmly engaged in the engagement seat the device being characterized by - a first electrically operated valve associated to the discharge opening of the first pump or compressor, said first electrically operated valve being a normally open type valve or normally closed type valve, i.e. capable of allowing priming of air from said discharge opening when said valve is not excited or is excited, respectively; - a second electrically operated valve associated to the suction opening of the second pump or compressor, said second electrically operated valve being a normally open type valve or normally closed type valve, i.e. capable of allowing suction of air from said suction opening when said valve is not excited or is excited, respectively.