mhurhangee/ep-ind-claims huggingface dataset:
A compound having structural Formula I: or a pharmaceutically acceptable salt thereof wherein: R 1 is -H, -F, -OH, -C 1-3 alkyl or -OC 1-3 alkyl; R 2 is -H, or C 1-4 alkyl; R 3 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F; R 4 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F; R 5 is -H, halo, -C 3-6 cycloalkyl or -C 1-3 alkyl; R 6 is -H or -C 1-3 alkyl when the dashed bond is absent, or R 6 is absent when the dashed bond is a double bond; n is zero where R 6 is absent, or one where R 6 is present; Z is Y 1, Y 2, Y 3 and Y 4 are each independently selected from C(R 7) or N; provided that at most two of Y 1, Y 2, Y 3 and Y 4 are N; each R 7 is independently -H, halo, C 1-4 alkyl optionally substituted with 1-3 of -F, or OC 1-4 alkyl; R 8 is -H, halo, or C 1-4 alkyl optionally substituted with 1-3 of -F; R 9 is -H, C 1-4 alkyl optionally substituted with 1-3 of -F, or halo; and R 10 is-H or C 1-4 alkyl. R 1 is -H, -F, -OH, -C 1-3 alkyl or -OC 1-3 alkyl; R 2 is -H, or C 1-4 alkyl; R 3 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F; R 4 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F; R 5 is -H, halo, -C 3-6 cycloalkyl or -C 1-3 alkyl; R 6 is -H or -C 1-3 alkyl when the dashed bond is absent, or R 6 is absent when the dashed bond is a double bond; n is zero where R 6 is absent, or one where R 6 is present; Z is Y 1, Y 2, Y 3 and Y 4 are each independently selected from C(R 7) or N; provided that at most two of Y 1, Y 2, Y 3 and Y 4 are N; each R 7 is independently -H, halo, C 1-4 alkyl optionally substituted with 1-3 of -F, or OC 1-4 alkyl; R 8 is -H, halo, or C 1-4 alkyl optionally substituted with 1-3 of -F; R 9 is -H, C 1-4 alkyl optionally substituted with 1-3 of -F, or halo; and R 10 is-H or C 1-4 alkyl.
A wheel balancing device, comprising a rotation shaft on which a wheel can be mounted and means for fixing said wheel to said rotation shaft, comprising: - a plate, which is adapted to be fixed rigidly to a tire removing device, - a tubular element, which is connected to said plate, said tubular element accommodating rotatably said rotation shaft, - sensor means (7, 9), which are fixed to said plate, are connected to said tubular element and are adapted to measure the forces that constrain said tubular element when said rotation shaft and said wheel are turning and to provide a measurement of the forces generated by the dynamic imbalance of said wheel, characterised in that said plate comprises a plurality of slots adapted to accommodate the ends of arms of said tire removing device for the rigid fixing of said wheel balancing device to said tire removing device. - a plate, which is adapted to be fixed rigidly to a tire removing device, - a tubular element, which is connected to said plate, said tubular element accommodating rotatably said rotation shaft, - sensor means (7, 9), which are fixed to said plate, are connected to said tubular element and are adapted to measure the forces that constrain said tubular element when said rotation shaft and said wheel are turning and to provide a measurement of the forces generated by the dynamic imbalance of said wheel, characterised in that said plate
A fluid pump for usage in a massage system in a vehicle seat comprising - a housing with a front wall at a front side and a rear wall at a rear side, - a first actuator element which is movable forwards and backwards, and - a second actuator element which is configured to be counter-directionally movable with respect to the first actuator element, - a first piston and a second piston arranged at the front side, wherein the first piston and the second piston are movable backwards during an intake stroke and forwards during an exhaust stroke, and - a third piston and a fourth piston arranged at the rear side, wherein the third piston and the fourth piston are movable forwards during an intake stroke and backwards during an exhaust stroke, wherein the first actuator element is coupled to the first piston and the third piston such that the first piston performs an intake stroke and the third piston performs an exhaust stroke when the first actuator element moves backwards, and such that the first piston performs an exhaust stroke and the third piston performs an intake stroke when the first actuator element moves forwards, and the second actuator element is coupled to the second piston and to the fourth piston such that the second piston performs an exhaust stroke and the fourth piston performs an intake stroke when the second actuator element moves forwards, and such that the second piston performs intake stroke and the fourth piston performs an exhaust stroke when the second actuator element moves backwards, characterized in that a coil (69, 71) is mounted on the first actuator element and/or the second actuator element, a permanent magnet is located in a sandwich configuration between the first actuator element and the second actuator element, and at least one rolling element (89, 91, 93) having an axis of rotation perpendicular to the linear axis of motion of the actuator elements (65, 67) is provided between the first actuator element and the second actuator element such that both the first actuator element and the second actuator element are in driving contact with the rolling element (89, 91, 93) from opposite sides with respect to the axis of rotation of the rolling element. - a housing with a front wall at a front side and a rear wall at a rear side, - a first actuator element which is movable forwards and backwards, and - a second actuator element which is configured to be counter-directionally movable with respect to the first actuator element, - a first piston and a second piston arranged at the front side, wherein the first piston and the second piston are movable backwards during an intake stroke and forwards during an exhaust stroke, and - a third piston and a fourth piston arranged at the rear side, wherein the third piston and the fourth piston are movable forwards during an intake stroke and backwards during an exhaust stroke,
A method performed by a processor of a vehicle control unit for managing a driving condition anomaly, comprising: receiving a first driving condition based on data from a first vehicle sensor of a vehicle; receiving a second driving condition based on data from another data source; determining a driving condition anomaly based on the first driving condition and the second driving condition; sending a request for information to a driving condition database remote from the vehicle; receiving the requested information from the driving condition database; the method being characterised by comprising: resolving the driving condition anomaly based on the requested information from the driving condition database. receiving a first driving condition based on data from a first vehicle sensor of a vehicle; receiving a second driving condition based on data from another data source; determining a driving condition anomaly based on the first driving condition and the second driving condition; sending a request for information to a driving condition database remote from the vehicle; receiving the requested information from the driving condition database; the method being characterised by comprising: resolving the driving condition anomaly based on the requested information from the driving condition database.
A curable film-forming composition comprising: (a) a polymeric binder comprising at least one polymeric resin having reactive functional groups; (b) a curing agent containing functional groups that are reactive with the reactive functional groups of (a); and (c) silica particles that have been functionalized on their surfaces with an amino silane so as to impart the surfaces with primary amino functional groups; wherein after application to a substrate as a coating and after curing, the curable film-forming composition demonstrates - an initial 85° gloss of less than 30 and an increase in 85° gloss of no more than 10 gloss units when subjected to WET ABRASION TEST METHOD ONE; or - an initial 85° gloss of less than 30 and an increase in 85° gloss of no more than 15 gloss units when subjected to WET ABRASION TEST METHOD TWO. (a) a polymeric binder comprising at least one polymeric resin having reactive functional groups; (b) a curing agent containing functional groups that are reactive with the reactive functional groups of (a); and (c) silica particles that have been functionalized on their surfaces with an amino silane so as to impart the surfaces with primary amino functional groups; - an initial 85° gloss of less than 30 and an increase in 85° gloss of no more than 10 gloss units when subjected to WET ABRASION TEST METHOD ONE; or - an initial 85° gloss of less than 30 and an increase in 85° gloss of no more than 15 gloss units when subjected to WET ABRASION TEST METHOD TWO.
A radiation curable composition including at least one organic silver salt, at least one reducing agent for the organic silver salt, and a polymerizable composition of at least one polymerizable compound, wherein the radiation curable composition is a radiation curable inkjet ink containing at least 50 wt% of a monofunctional polymerizable compound based on the total weight of the polymerizable composition, wherein the at least one polymerizable compound includes a monomer comprising at least an acetal group or a ketal group.
An auxiliary instrument (10, 10A, 10B, 50, 70) for dental use used as a reference of alignment for creating three-dimensional intraoral image data by connecting a plurality of pieces of three-dimensional image data obtained by three-dimensionally measuring an inside of an oral cavity, the auxiliary instrument (10, 10A, 10B, 50, 70) comprising: a sheet portion (11, 11a, 11b) having a first surface and a second surface opposed to the first surface; a plurality of identification portions formed in a thickness direction of the sheet portion (11, 11a, 11b) from the first surface of the sheet portion (11, 11a, 11b), each of the plurality of identification portions having a three-dimensional shape configured to be identified, characterized by a lip portion configured to widen and fix a lip of a patient; a mouth corner portion coupled to the lip portion by a coupling portion, the mouth corner portion configured to widen and fix a mouth corner of the patient; and a handle portion connected to the mouth corner portion, the handle portion configured to be gripped, wherein the sheet portion is connected to the lip portion and/or the mouth corner portion and extends from the lip portion and/or the mouth corner portion toward an inside of the oral cavity, wherein the auxiliary instrument (10, 10A, 10B, 50, 70) is formed of a material including a coloring agent recognized to have biological safety, the material to which an X-ray contrast medium is added. a sheet portion (11, 11a, 11b) having a first surface and a second surface opposed to the first surface; a plurality of identification portions formed in a thickness direction of the sheet portion (11, 11a, 11b) from the first surface of the sheet portion (11, 11a, 11b), each of the plurality of identification portions having a three-dimensional shape configured to be identified, characterized by a lip portion configured to widen and fix a lip of a patient; a mouth corner portion coupled to the lip portion by a coupling portion, the mouth corner portion configured to widen and fix a mouth corner of the patient; and a handle portion connected to the mouth corner portion, the handle portion configured to be gripped, wherein the sheet portion is connected to the lip portion and/or the mouth corner portion and extends from the lip portion and/or the mouth corner portion toward an inside of the oral cavity, wherein the auxiliary instrument (10, 10A, 10B, 50, 70) is formed of a material including a coloring agent recognized to have biological safety, the material to which an X-ray contrast medium is added.
A set comprising: a climbing plane of a step stool or a stepladder comprising two strings connected by a plurality of parallel rungs including an end rung, each of the strings comprising hollows leading above the end rung, a shelf for supporting a predetermined load, the shelf comprising a fastening part provided with two members able to be fitted within the hollows, so as to enable the shelf to be mounted to the strings, the shelf being characterised in that it comprises a protrusion configured to contact the end rung when the shelf is mounted to the climbing plane, so as to form a support. a climbing plane of a step stool or a stepladder comprising two strings connected by a plurality of parallel rungs including an end rung, each of the strings comprising hollows leading above the end rung, a shelf for supporting a predetermined load, the shelf comprising a fastening part provided with two members able to be fitted within the hollows, so as to enable the shelf to be mounted to the strings, the shelf being characterised in that it comprises a protrusion configured to contact the end rung when the shelf is mounted to the climbing plane, so as to form a support.
A heating device comprising: a substrate; a connection terminal electrically connected to the substrate; and a heating member electrically connected to the connection terminal, wherein the connection terminal comprises: a first region comprising an inner side portion and an outer side portion; a third region electrically connected to the substrate; and a second region disposed between the first region and the third region, and wherein the heating member is disposed between the inner side portion and the outer side portion of the connection terminal characterized in that a height at which the inner side portion is positioned and a height at which the outer side portion is positioned in the optical axis direction are different from each other. a substrate; a connection terminal electrically connected to the substrate; and a heating member electrically connected to the connection terminal, wherein the connection terminal comprises: a first region comprising an inner side portion and an outer side portion; a third region electrically connected to the substrate; and a second region disposed between the first region and the third region, and wherein the heating member is disposed between the inner side portion and the outer side portion of the connection terminal characterized in that a height at which the inner side portion is positioned and a height at which the outer side portion is positioned in the optical axis direction are different from each other. a first region comprising an inner side portion and an outer side portion; a third region electrically connected to the substrate; and a second region disposed between the first region and the third region, and wherein the heating member is disposed between the inner side portion and the outer side portion of the connection terminal characterized in that a height at which the inner side portion is positioned and a height at which the outer side portion is positioned in the optical axis direction are different from each other.
Nanoparticles with a plasmon resonance peak between 800 nm and 1300 nm or from 1600 nm to 1850 nm for use in a method of treating a malignant or benign tumour, an inflammatory response or an autoimmune disease by inducing localized hyperthermia in a cell or tissue by delivering said nanoparticles to said cell or tissue and exposing said nanoparticles to an excitation source at its plasmon resonance peak under conditions wherein said nanoparticles emit heat upon exposure to said excitation source.
A method for a first device to transmit files stored in a predetermined directory structure to a second device, the method comprising: identifying a plurality of files to be transmitted among the stored files; generating a metadata file comprising a first uniform resource locator, URL, indicating information about a location in which a list of the plurality of files to be transmitted can be acquired, said list including, for each file of said plurality of files to be transmitted, a resource URL where each file may be acquired; transmitting the generated metadata file to the second device; receiving, from the second device, a request message including one of the plurality of resource URLs; generating a response message including a header of a target file and the target file, wherein the target file is one of the plurality of identified files and corresponds to said one of the plurality of resource URLs and the header comprises individual information related to the location of the directory in which the target file is to be stored in response to the request message; and transmitting the response message to the second device. identifying a plurality of files to be transmitted among the stored files; generating a metadata file comprising a first uniform resource locator, URL, indicating information about a location in which a list of the plurality of files to be transmitted can be acquired, said list including, for each file of said plurality of files to be transmitted, a resource URL where each file may be acquired; transmitting the generated metadata file to the second device; receiving, from the second device, a request message including one of the plurality of resource URLs; generating a response message including a header of a target file and the target file, wherein the target file is one of the plurality of identified files and corresponds to said one of the plurality of resource URLs and the header comprises individual information related to the location of the directory in which the target file is to be stored in response to the request message; and transmitting the response message to the second device.
Differential dosing unit with pressure compensation that is connected to a processing system via a discharge device characterised in that the differential dosing unit has a first vertical flange fitted on its outlet section and that a second vertical flange is located opposite the first one, whereby the flanges (5, 7) are connected to the discharge device via vertically aligned pressure compensators (6, 8).
A cowl structure (12; 112; 212; 132) for an automobile, comprising: a guide plate (38; 138) that is disposed in a cowl portion of a vehicle and guides at least liquid that ingresses into the cowl portion through a cowl louver toward a vehicle forward side; and a plurality of screen plates (34A, 34B; 234A, 234B; 334A, 334B) that are provided standing inside the cowl portion, that impede movement in a vehicle width direction of air that enters from a power plant compartment, and that are joined by the guide plate (38; 138), characterized in that at least one of an upper side portion or a lower side portion, of each screen plate (34A, 34B; 234A, 234B; 334A, 334B), relative to a boundary with the guide plate (38; 138) being an inclined portion (36U, 36L) that is inclined from a vertical direction. a guide plate (38; 138) that is disposed in a cowl portion of a vehicle and guides at least liquid that ingresses into the cowl portion through a cowl louver toward a vehicle forward side; and a plurality of screen plates (34A, 34B; 234A, 234B; 334A, 334B) that are provided standing inside the cowl portion, that impede movement in a vehicle width direction of air that enters from a power plant compartment, and that are joined by the guide plate (38; 138), characterized in that at least one of an upper side portion or a lower side portion, of each screen plate (34A, 34B; 234A, 234B; 334A, 334B), relative to a boundary with the guide plate (38; 138) being an inclined portion (36U, 36L) that is inclined from a vertical direction.
A compound selected from the group consisting of: -3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1-methyl-1H-1,2,4-triazol-5 -one; and -4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; or a pharmaceutically acceptable salt thereof. -3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(2-fluoro-4-(3-methylquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one; -4-(4-(3-chloroquinolin-7-yl)-2-fluorophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1-methyl-1H-1,2,4-triazol-5 -one; and -4-(2-fluoro-4-(3-fluoroquinolin-7-yl)phenyl)-1-methyl-3-((1-propionylpyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5 -one;
An unbonded flexible pipe for transporting an abrasive material, comprising: - at least one tubular sheath delimiting a passage for circulation of the abrasive material; - at least one layer (34, 36) of tensile armors positioned externally with respect to the tubular sheath, the armor layer (34, 36) comprising a plurality of filiform armor elements, characterized in that it further comprises a protective internal layer positioned inside the tubular sheath in the circulation passage, the protective internal layer including an elastomeric matrix and a longitudinal reinforcement assembly embedded in the matrix. - at least one tubular sheath delimiting a passage for circulation of the abrasive material; - at least one layer (34, 36) of tensile armors positioned externally with respect to the tubular sheath, the armor layer (34, 36) comprising a plurality of filiform armor elements,
A recombinant adeno-associated virus vector of pseudotype 2/7 or 2/8 encoding SMN-1, for use in a method of treating a mammal having spinal muscular atrophy, wherein the vector is to be injected into the spinal cord of the mammal.