An article of footwear, comprising: an upper; and a sole structure connected to the upper and including: a midsole connected to the upper; and an outsole engaged with the midsole, the outsole including a plurality of lugs extending from a base surface, the lugs being polygonal and uniform in shape and arranged to form a ground contacting surface of the outsole, and wherein the lugs are sized, shaped or spaced from one another to provide regions of the outsole with different impact-attenuation characteristics, including the following regions: (a) a high pressure or force bearing region including a first plurality of lugs (310a, 410a) located at a central portion of the outsole expending at least from a heel region to a ball of the foot region and (b) a low pressure or force bearing region including a second plurality of lugs (310b, 410b) located at a periphery of the central portion, wherein at least some of the second plurality of lugs in the low pressure or force bearing region are smaller in size, have a smaller wall thickness, and/or are more spaced apart from other lugs as compared with at least some of the first plurality of lugs in the high pressure or force bearing region. an upper; and a sole structure connected to the upper and including: a midsole connected to the upper; and an outsole engaged with the midsole, the outsole including a plurality of lugs extending from a base surface, the lugs being polygonal and uniform in shape and arranged to form a ground contacting surface of the outsole, and wherein the lugs are sized, shaped or spaced from one another to provide regions of the outsole with different impact-attenuation characteristics, including the following regions: (a) a high pressure or force bearing region including a first plurality of lugs (310a, 410a) located at a central portion of the outsole expending at least from a heel region to a ball of the foot region and (b) a low pressure or force bearing region including a second plurality of lugs (310b, 410b) located at a periphery of the central portion, wherein at least some of the second plurality of lugs in the low pressure or force bearing region are smaller in size, have a smaller wall thickness, and/or are more spaced apart from other lugs as compared with at least some of the first plurality of lugs in the high pressure or force bearing region. a midsole connected to the upper; and an outsole engaged with the midsole, the outsole including a plurality of lugs extending from a base surface, the lugs being polygonal and uniform in shape and arranged to form a ground contacting surface of the outsole, and wherein the lugs are sized, shaped or spaced from one another to provide regions of the outsole with different impact-attenuation characteristics, including the following regions: (a) a high pressure or force bearing region including a first plurality of lugs (310a, 410a) located at a central portion of the outsole expending at least from a heel region to a ball of the foot region and (b) a low pressure or force bearing region including a second plurality of lugs (310b, 410b) located at a periphery of the central portion, wherein at least some of the second plurality of lugs in the low pressure or force bearing region are smaller in size, have a smaller wall thickness, and/or are more spaced apart from other lugs as compared with at least some of the first plurality of lugs in the high pressure or force bearing region.