mhurhangee/ep-ind-claims huggingface dataset:
A system for heating a sample comprising: a heated stage assembly configured to be attached to a microscope stage holder, the heated stage assembly configured to position the sample over an objective lens of the microscope stage holder, the heated stage assembly comprising: a mounting adapter element for attaching the heated stage assembly to the microscope stage holder; a sample holder element mounted within the mounting adapter element, the sample holder element including a first surface opposed to a second surface, the first surface including a sample receiving area configured to receive a microscope slide; one or more heating elements attached to the mounting adapter element; and a thermally conducting optical window holder element disposed on the first surface and positioned above the sample receiving area and at least partially enclosing an optical window element of the system, wherein the optical window element is configured to contact the sample and is configured to be heated by the thermally conducting optical window holder element configured to uniformly distribute heat to the sample, characterised in that the one or more heating elements are in contact with at least a portion of the second surface. a mounting adapter element for attaching the heated stage assembly to the microscope stage holder; a sample holder element mounted within the mounting adapter element, the sample holder element including a first surface opposed to a second surface, the first surface including a sample receiving area configured to receive a microscope slide; one or more heating elements attached to the mounting adapter element; and a thermally conducting optical window holder element disposed on the first surface and positioned above the sample receiving area and at least partially enclosing an optical window element of the system, wherein the optical window element is configured to contact the sample and is configured to be heated by the thermally conducting optical window holder element configured to uniformly distribute heat to the sample,
A combination comprising an immune checkpoint inhibitor and a single-stranded antisense oligonucleotide targeted to STAT3 for use in the treatment of cancer.
A labeling reagent for labeling a target, said labeling reagent comprising a marker moiety M and a reactive group R M-L-R wherein said marker moiety M and said reactive group R are covalently linked together by a linker arm L comprising a backbone which comprises at least one rigid group that comprises one or more of: (a) (b) (c) (d) multimers of (a), (b) or (c), and (e) any combinations of (a), (b), (c) and (d); said M comprising a fluorescent dye; and wherein R is such that said target is labeled by forming a carbon-carbon bond between a carbon atom in said target and a carbon atom in said labeling reagent by means of said reactive group R. (a) (b) (c) (d) multimers of (a), (b) or (c), and (e) any combinations of (a), (b), (c) and (d);
An oil separator that separates mist oil from processing-target gas containing the mist oil, the oil separator characterized by comprising: a plurality of separation disks being stacked and spaced in an axial direction, wherein each of the plurality of separation disks is configured to rotate around an axis to capture mist oil contained in processing-target gas, and wherein each of the plurality of separation disks comprises: an inner peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the inner peripheral part being inclined with respect to a radial direction toward one side in the axial direction; and an outer peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the outer peripheral part continuously extending outward from an outer peripheral edge of the inner peripheral part, the outer peripheral part being inclined with respect to the radial direction toward another side in the axial direction. a plurality of separation disks being stacked and spaced in an axial direction, wherein each of the plurality of separation disks is configured to rotate around an axis to capture mist oil contained in processing-target gas, and wherein each of the plurality of separation disks comprises: an inner peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the inner peripheral part being inclined with respect to a radial direction toward one side in the axial direction; and an outer peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the outer peripheral part continuously extending outward from an outer peripheral edge of the inner peripheral part, the outer peripheral part being inclined with respect to the radial direction toward another side in the axial direction. an inner peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the inner peripheral part being inclined with respect to a radial direction toward one side in the axial direction; and an outer peripheral part forming a surface of a frustum of a hypothetical cone or pyramid coaxial with the separation disk, the outer peripheral part continuously extending outward from an outer peripheral edge of the inner peripheral part, the outer peripheral part being inclined with respect to the radial direction toward another side in the axial direction.
A trolley for the carriage of shopping or other goods embodying a platform on which a child may stand, comprising a container, a member for supporting the container for said goods, at least one first ground engaging wheel which can freely rotate about an axis located at the rear of said container, a platform located close to the wheel axis to support a standing child, a handle (10,16) to push or pull the trolley, and at least one second ground engaging wheel forward of the at least one rear wheel (3,) characterised in that the trolley is configured such that the handle and the container-supporting member are capable of adopting two operative positions, in the first operative position the container and handle are in their most upright position and the plane of the platform is at an unsuitable angle for a standing child, and in the second operative position the handle extends rearward and the container tilts forward away from its most upright position allowing the platform to adopt a substantially horizontal plane suitable for a standing child.
A patterned substrate comprising: a functionalizable layer comprising one or more functional groups; a UV-cured polymer layer comprising a plurality of micro-scale or nano-scale patterns, or combinations thereof; and a backing layer; wherein the functionalizable layer comprises a reactive silane layer, a functionalizable hydrogel or polymer, said functionalizable hydrogel or polymer comprising the one or more functional groups, wherein the one or more functional groups are capable of attaching to biomolecules, and wherein the UV-cured polymer layer comprises at least one photocurable polymer and is free of photoresist. a functionalizable layer comprising one or more functional groups; a UV-cured polymer layer comprising a plurality of micro-scale or nano-scale patterns, or combinations thereof; and a backing layer; wherein the functionalizable layer comprises a reactive silane layer, a functionalizable hydrogel or polymer, said functionalizable hydrogel or polymer comprising the one or more functional groups, wherein the one or more functional groups are capable of attaching to biomolecules, and wherein the UV-cured polymer layer comprises at least one photocurable polymer and is free of photoresist.
A display device for a vehicle comprising: a liquid crystal panel displaying an image; a light source illuminating the liquid crystal panel by light emission; and a controlling means controlling the liquid crystal panel and the light source, wherein the liquid crystal panel includes: a particular display pixel displaying a particular image at a particular time; and a normal display pixel displaying a normal image at a normal time when the particular image is not displayed by the particular display pixel and at the particular time, wherein the controlling means controls a ratio of a gradation value of the normal display pixel to a set gradation value of the normal display pixel as a gradation ratio of the normal display pixel, and further controls a ratio of a gradation value of the particular display pixel to a set gradation value of the particular display pixel as a gradation ratio of the particular display pixel, characterised in that the controlling means sets first and second modes as control modes, the first mode in which the light source emits light, and the second mode in which the light source emits light with brightness lower than in the first mode, and in the first mode, the controlling means sets the gradation ration of the normal display pixel at the particular time to maximum, and further sets the gradation ratio of the particular display pixel at the particular time to maximum, and wherein, when intensity of light external to the vehicle is equal to or lower than a predetermined intensity, or when a light switch for a lamp of the vehicle turns on, the controlling means executes a gradation process to make the gradation ratio of the particular display pixel at the particular time larger than the gradation ratio of the normal display pixel, wherein, the control means changes the control mode from the first mode to the second mode when the intensity of light external to the vehicle is equal to or lower than the predetermined intensity, or when the light switch turns on, wherein, in the second mode, the controlling means executes the gradation process to make the gradation ratio of the particular display pixel at the particular time larger than the gradation ratio of the normal display pixel, wherein, in the first mode, the controlling means controls the liquid crystal panel to display both of the normal image and the particular image at the same time at the particular time, and in the second mode, the controlling means controls the liquid crystal panel to display both of the normal image and the particular image at the same time at the particular time, and further, executes the gradation process. a liquid crystal panel displaying an image; a light source illuminating the liquid crystal panel by light emission; and a controlling means controlling the liquid crystal panel and the light source,
A compound according to Claim 1 of Formula II: wherein: is X is O, S, CH 2 or N; m is 0 or 1; R 1 is independently selected from (C 1 -C 4)alkyl, pyrimidine, piperidine and phenyl, each optionally substituted with (C 1 -C 4)alkyl, OH, halo, O(C 1 -C 4)alkyl, methylpiperidine, S 2 R c, C N(R b) 2, or C O(C 1 -C 4)alkyl; R 2 is absent or H and R 3 is independently selected from: (C 1 -C 4)alkyl, pyranyl, cyclopentyl, cyclohexyl, cycloheptyl, thiopyranyl, pyrazolyl, piperidinyl, morpholinyl, piperazinyl each optionally substituted with one or more substituents independently selected from halo, OH, oxo, N(R b) 2, oxopyrrolidinyl, or morpholinyl, or R 2 and R 3 can be taken together with the nitrogen to which they are attached to form piperazine or morpholine, each optionally substituted with oxo; R 4 is independently H or methyl; R b is independently selected from H and (C 1 -C 4)alkyl; and R c is methyl; or a pharmaceutically acceptable salt thereof. X is O, S, CH 2 or N; m is 0 or 1; R 1 is independently selected from (C 1 -C 4)alkyl, pyrimidine, piperidine and phenyl, each optionally substituted with (C 1 -C 4)alkyl, OH, halo, O(C 1 -C 4)alkyl, methylpiperidine, S 2 R c, C N(R b) 2, or C O(C 1 -C 4)alkyl; R 2 is absent or H and R 3 is independently selected from: (C 1 -C 4)alkyl, pyranyl, cyclopentyl, cyclohexyl, cycloheptyl, thiopyranyl, pyrazolyl, piperidinyl, morpholinyl, piperazinyl each optionally substituted with one or more substituents independently selected from halo, OH, oxo, N(R b) 2, oxopyrrolidinyl, or morpholinyl, or R 2 and R 3 can be taken together with the nitrogen to which they are attached to form piperazine or morpholine, each optionally substituted with oxo; R 4 is independently H or methyl; R b is independently selected from H and (C 1 -C 4)alkyl; and R c is methyl; or a pharmaceutically acceptable salt thereof.
An apparatus for producing strain in an optical fibre proportional to dynamic pressure fluctuation in the surrounding substance, the apparatus comprising: a diaphragm having a first face that, in use, is exposed to dynamic pressure fluctuations in the substance, and a second, opposite face, the diaphragm being adapted to flex in response to dynamic pressure fluctuations applied to it; and one or more optical fibres mounted on either said first or said second face of the diaphragm, whereby strain is produced in the fibre when the diaphragm flexes, characterised in that the length of the diaphragm is at least 1x10 2 times the width of the diaphragm and the optical fibre or optical fibres extend longitudinally along the diaphragm and wherein the thickness of the diaphragm is in the range 0.5-50mm. a diaphragm having a first face that, in use, is exposed to dynamic pressure fluctuations in the substance, and a second, opposite face, the diaphragm being adapted to flex in response to dynamic pressure fluctuations applied to it; and one or more optical fibres mounted on either said first or said second face of the diaphragm, whereby strain is produced in the fibre when the diaphragm flexes, characterised in that the length of the diaphragm is at least 1x10 2 times the width of the diaphragm and the optical fibre or optical fibres extend longitudinally along the diaphragm and wherein the thickness of the diaphragm is in the range 0.5-50mm.
A ground aeration device comprising: a frame comprising a ground contact foot, supporting wheels; an air supply connector for receiving pressurised air from a source; an air supply splitter for directing air received from the source to a first air conduit and to a second air conduit; a drill element for insertion into the ground, the drill element being connected to the second air conduit to receive pressurised air for insertion into the ground, the drill element comprising at least one aperture for ejecting the pressurised air; at least one pneumatic means attached to the frame and connected to the drill element, the at least one pneumatic means being attached to the first air conduit for receiving pressurised air to drive the drill bit in and out of the ground; and air control means for controlling the supply of air through the first and second conduits respectively, and ejecting air through the aperture of the drill element when the drill element is inserted into the ground, characterised in that the device further comprises operating handles (3a, 3b), wherein the at least one pneumatic means is controlled by toggle switches comprised in a manifold located between the operating handles (3a, 3b), and wherein the ground contact foot engages with the ground, in use, when the drill element is inserted into the ground. a frame comprising a ground contact foot, supporting wheels; an air supply connector for receiving pressurised air from a source; an air supply splitter for directing air received from the source to a first air conduit and to a second air conduit; a drill element for insertion into the ground, the drill element being connected to the second air conduit to receive pressurised air for insertion into the ground, the drill element comprising at least one aperture for ejecting the pressurised air; at least one pneumatic means attached to the frame and connected to the drill element, the at least one pneumatic means being attached to the first air conduit for receiving pressurised air to drive the drill bit in and out of the ground; and air control means for controlling the supply of air through the first and second conduits respectively, and ejecting air through the aperture of the drill element when the drill element is inserted into the ground, characterised in that the device further comprises operating handles (3a, 3b), wherein the at least one pneumatic means is controlled by toggle switches comprised in a manifold located between the operating handles (3a, 3b), and wherein the ground contact foot engages with the ground, in use, when the drill element is inserted into the ground.
A pharmaceutical composition in the form of immediate release granules, wherein the pharmaceutical composition comprises: a) an agent from 25 to 85 % w/w in respect of the total amount of the pharmaceutical composition; b) up to 15.7 % w/w of water content in respect of the total amount of the pharmaceutical composition or the ratio water content / agent measured as anhydrous form is up to 31.5 % w/w; wherein the agent is the distrontium salt of the acid 2-(N,N-di(carboxymethyl)amino)-3-cyano-4-carboxymethyl-5-carboxythiophene, and wherein the D50 of the immediate release granules ranges from 140 to 800 microns. a) an agent from 25 to 85 % w/w in respect of the total amount of the pharmaceutical composition; b) up to 15.7 % w/w of water content in respect of the total amount of the pharmaceutical composition or the ratio water content / agent measured as anhydrous form is up to 31.5 % w/w; wherein the agent is the distrontium salt of the acid 2-(N,N-di(carboxymethyl)amino)-3-cyano-4-carboxymethyl-5-carboxythiophene, and wherein the D50 of the immediate release granules ranges from 140 to 800 microns.
A method for dissociating avidin or streptavidin from a biotin derivative which binds to avidin with lower affinity than biotin, comprising: mixing a combination of avidin with the biotin derivative, or a combination of streptavidin with the biotin derivative (hereinafter the combination being referred to as "avidin-biotin complex") with a water-soluble polymer to which biotin or a derivative thereof is bound at a density of 2 to 2,000 molecules per molecule of the polymer (hereinafter the polymer being referred to as "dissociation agent"), wherein the biotin derivative is a derivative of biotin having one order or less smaller binding constant with avidin than that of biotin with avidin (10 15 M -1) and has a cyclic moiety of biotin different from that of biotin, wherein the water-soluble polymer is selected from the group consisting of water-soluble proteins, polysaccharides, and organic synthetic polymers having reactive functional groups, and wherein the biotin derivative is a derivative having the same cyclic moiety as biotin. mixing a combination of avidin with the biotin derivative, or a combination of streptavidin with the biotin derivative (hereinafter the combination being referred to as "avidin-biotin complex") with a water-soluble polymer to which biotin or a derivative thereof is bound at a density of 2 to 2,000 molecules per molecule of the polymer (hereinafter the polymer being referred to as "dissociation agent"), wherein the biotin derivative is a derivative of biotin having one order or less smaller binding constant with avidin than that of biotin with avidin (10 15 M -1) and has a cyclic moiety of biotin different from that of biotin, wherein the water-soluble polymer is selected from the group consisting of water-soluble proteins, polysaccharides, and organic synthetic polymers having reactive functional groups, and wherein the biotin derivative is a derivative having the same cyclic moiety as biotin.
A non-explosive downhole cutting or perforating tool for creating openings in tubulars (16, 18) and/or earthen formations, the tool comprising: a carrier holding a thermate material; an igniter in operational contact with the thermate material; a penetrator head connected with the carrier, the penetrator head including a body that forms one or more ports oriented radially relative to the longitudinal axis of the tool and a communication path extending from the thermate material to the one or more ports; and a moveable member in a closed position blocking the communication path and in an open position opening the communication path, wherein the moveable member is operated from the closed position to the open position in response to ignition of the thermate material to eject molten metal product produced from ignition of the thermate material through the one or more ports characterized in that the movable member is a valve member of a one-way valve. a carrier holding a thermate material; an igniter in operational contact with the thermate material; a penetrator head connected with the carrier, the penetrator head including a body that forms one or more ports oriented radially relative to the longitudinal axis of the tool and a communication path extending from the thermate material to the one or more ports; and a moveable member in a closed position blocking the communication path and in an open position opening the communication path, wherein the moveable member is operated from the closed position to the open position in response to ignition of the thermate material to eject molten metal product produced from ignition of the thermate material through the one or more ports characterized in that the movable member is a valve member of a one-way valve.
A preformed guidewire comprising a continuous inner corewire, the inner corewire including a proximal region and a distal region, the distal region terminating into an atraumatic tip, wherein the distal region includes a proximal segment and a distal segment, the proximal and distal segments extending along paths that curve in opposite directions, wherein the atraumatic tip is located within the enlarged curvature of the proximal segment and wherein the distal region lies in a single plane.
A piezoelectric element comprising, on a substrate in the following order: a lower electrode layer; a piezoelectric film containing a perovskite-type oxide as a main component; and an upper electrode layer, wherein at least a region of the upper electrode layer closest to a side of the piezoelectric film is composed of an oxide conductive layer containing In, characterized in that in an interface region between the piezoelectric film and the oxide conductive layer of the upper electrode layer, when an intensity profile of binding energy, which is acquired by an X-ray photoelectron spectroscopy measurement, in a case where a peak intensity of binding energy derived from a 3d 5/2 orbital of In bonded to oxygen is defined as α, and a peak intensity of binding energy derived from a 3d 5/2 orbital of In bonded to an OH group is defined as γ, a peak intensity ratio γ/α satisfies formula, γ / α ≤ 0.25 a lower electrode layer; a piezoelectric film containing a perovskite-type oxide as a main component; and an upper electrode layer, wherein at least a region of the upper electrode layer closest to a side of the piezoelectric film is composed of an oxide conductive layer containing In, characterized in that in an interface region between the piezoelectric film and the oxide conductive layer of the upper electrode layer, when an intensity profile of binding energy, which is acquired by an X-ray photoelectron spectroscopy measurement, in a case where a peak intensity of binding energy derived from a 3d 5/2 orbital of In bonded to oxygen is defined as α, and a peak intensity of binding energy derived from a 3d 5/2 orbital of In bonded to an OH group is defined as γ, a peak intensity ratio γ/α satisfies formula, γ / α ≤ 0.25