A manifold for collecting a tissue sample through a suction line, said manifold comprising: a housing defining a manifold volume, an inlet bore (114a, 114b) in fluid communication with said manifold volume and adapted to be in fluid communication with the suction line, an accessory opening that opens into an accessory sleeve in fluid communication with said manifold volume, and an outlet opening adapted to be in fluid communication with a suction source to provide a first suction path from the suction line to said outlet opening through said accessory sleeve and said manifold volume, wherein said housing comprises locating features disposed within said accessory sleeve; and a tray comprising a control surface, a sealing surface coupled to said control surface, a base portion, and side portion coupled to said base portion with said base and said side portions (184, 185) extending from said sealing surface and defining a tissue collecting cavity, and porous features within said base portion, wherein said tray is adapted to be removably coupled with said housing such that (i) said sealing surface seals said accessory opening, (ii) said tissue collecting cavity is positioned within said accessory sleeve and opening towards said inlet bore (114a, 114b), and (iii) said base portion and/or said side portion engages said locating features within said accessory sleeve to provide a gap between said base portion of said tray and a lower barrier of said housing defining said accessory sleeve,wherein said control surface of said tray is adapted to receive an input from a user to move said sealing surface away from a portion of said accessory opening near said lower barrier to provide and locate a second suction path from said accessory opening to said outlet opening through said gap between said base portion of said tray and said lower barrier of said housing defining said accessory sleeve, and wherein said tray further comprises a grip defining said control surface with said sealing surface rigidly coupled to said grip, and wherein said grip is configured to pivot said sealing surface away from said portion of said accessory opening near said lower barrier; characterized in that said grip comprises a first portion and a second portion (188a, 188b) extending from said sealing surface with said first and second portions (188a, 188b) configured to be pinched by the user to move said first portion towards said second portion and pivot said sealing surface away from said portion of said accessory opening near said lower barrier, wherein said sealing surface comprises resiliently flexible material and is configured to pivotably flex away from said portion of said accessory opening near said lower barrier. a housing defining a manifold volume, an inlet bore (114a, 114b) in fluid communication with said manifold volume and adapted to be in fluid communication with the suction line, an accessory opening that opens into an accessory sleeve in fluid communication with said manifold volume, and an outlet opening adapted to be in fluid communication with a suction source to provide a first suction path from the suction line to said outlet opening through said accessory sleeve and said manifold volume, wherein said housing comprises locating features disposed within said accessory sleeve; and a tray comprising a control surface, a sealing surface coupled to said control surface, a base portion, and side portion coupled to said base portion with said base and said side portions (184, 185) extending from said sealing surface and defining a tissue collecting cavity, and porous features within said base portion, wherein said tray is adapted to be removably coupled with said housing such that (i) said sealing surface seals said accessory opening, (ii) said tissue collecting cavity is positioned within said accessory sleeve and opening towards said inlet bore (114a, 114b), and (iii) said base portion and/or said side portion engages said locating features within said accessory sleeve to provide a gap between said base portion of said tray and a lower barrier of said housing defining said accessory sleeve,wherein said control surface of said tray is adapted to receive an input from a user to move said sealing surface away from a portion of said accessory opening near said lower barrier to provide and locate a second suction path from said accessory opening to said outlet opening through said gap between said base portion of said tray and said lower barrier of said housing defining said accessory sleeve, and wherein said tray further comprises a grip defining said control surface with said sealing surface rigidly coupled to said grip, and wherein said grip is configured to pivot said sealing surface away from said portion of said accessory opening near said lower barrier; characterized in that said grip comprises a first portion and a second portion (188a, 188b) extending from said sealing surface with said first and second portions (188a, 188b) configured to be pinched by the user to move said first portion towards said second portion and pivot said sealing surface away from said portion of said accessory opening near said lower barrier, wherein said sealing surface comprises resiliently flexible material and is configured to pivotably flex away from said portion of said accessory opening near said lower barrier.