A system, comprising: a myocardial stimulator adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing; a neural stimulator adapted to deliver neural stimulation through at least one electrode to at least one desired neural target to elicit at least one of a parasympathetic response or a sympathetic response; a controller connected to the myocardial stimulator and to the neural stimulator, wherein the controller is adapted to: intermittently deliver a sympathetic stimulus using the myocardial stimulator, the sympathetic stimulus including a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing, the sequence of stress-inducing pacing resulting in a parasympathetic reflex after the sequence of stress-inducing pacing; implement a neural stimulation therapy using the neural stimulator, and coordinate timing between the sequence of stress-inducing pacing pulses and the neural stimulation to enhance the parasympathetic reflex after the sequence of stress-inducing pacing, including timing neural stimulation to elicit at least one of: the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex; or the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus. a myocardial stimulator adapted to deliver pacing pulses through at least one electrode to provide cardiac pacing; a neural stimulator adapted to deliver neural stimulation through at least one electrode to at least one desired neural target to elicit at least one of a parasympathetic response or a sympathetic response; a controller connected to the myocardial stimulator and to the neural stimulator, wherein the controller is adapted to: intermittently deliver a sympathetic stimulus using the myocardial stimulator, the sympathetic stimulus including a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing, the sequence of stress-inducing pacing resulting in a parasympathetic reflex after the sequence of stress-inducing pacing; implement a neural stimulation therapy using the neural stimulator, and coordinate timing between the sequence of stress-inducing pacing pulses and the neural stimulation to enhance the parasympathetic reflex after the sequence of stress-inducing pacing, including timing neural stimulation to elicit at least one of: the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex; or the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus. intermittently deliver a sympathetic stimulus using the myocardial stimulator, the sympathetic stimulus including a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing, the sequence of stress-inducing pacing resulting in a parasympathetic reflex after the sequence of stress-inducing pacing; implement a neural stimulation therapy using the neural stimulator, and coordinate timing between the sequence of stress-inducing pacing pulses and the neural stimulation to enhance the parasympathetic reflex after the sequence of stress-inducing pacing, including timing neural stimulation to elicit at least one of: the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex; or the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus. the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex; or the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.