An apparatus for detecting a disease in a subject in vitro, comprising a delivery system and at least two sub-equipment units which are combined or integrated in the apparatus, wherein the delivery system is capable of delivering a biological sample to at least one of the sub-equipment units and each sub-equipment unit is capable of detecting at least one property of the biological sample; wherein at least one of the sub-equipment units comprises (a) a first layer of material having an exterior surface and an interior surface, wherein the interior surface defines one or more inter-unit channels in which the biological sample flows through the sub-equipment unit; (b) a first sorting unit capable of detecting a property of the biological sample at the microscopic level and sorting the biological sample by the detected property; (c) a first detection unit capable of detecting the same or different property of the sorted biological sample at the microscopic level, without sorting the biological sample; wherein the first sorting unit and the first detection unit are integrated into the first layer of material and positioned to be at least partially exposed in the inter-unit channel; and (d) a second sorting unit, wherein the biological sample flows by or through the first sorting unit before reaching the second sorting unit, and the second sorting unit is capable of detecting the same or different property of the biological sample as the first sorting unit and sorts the biological sample by the property it detects; and wherein the delivery system comprises a layer of material having an interior surface, wherein the interior surface defines one or more intra-unit channels in which the biological sample flows to the inter-unit channel or inter-unit channels of one or more desired sub-equipment units; wherein the layer that defines the inter-unit or intra-unit channel comprises a biocompatible material on its interior surface; wherein the biological sample comprises cells, a sample of an organ or tissue, DNA, RNA, virus, or protein; wherein each property to be detected by a sub-equipment unit or a detection unit or a sorting unit is detected by a sensor, and said properties are, independently, thermal, optical, acoustical, biological, chemical, physical-chemical, electro-mechanical, electro-chemical, electro-chemical-mechanical, bio-physical, bio-chemical, bio-mechanical, bio-electrical, electro-optical, bioelectro-optical, bio-thermal optical, electro-chemical optical, bio-physical-chemical, bio-electrophysical, bio-electro-mechanical, bio-electro-chemical, bio-chemical-mechanical, bio-electrophysical-chemical, bio-electro-physical-mechanical, bio-electro-chemical-mechanical, electric, magnetic, electro-magnetic, physical, or mechanical properties of the biologic sample; wherein the disease is selected from a cancer or heart disease. (a) a first layer of material having an exterior surface and an interior surface, wherein the interior surface defines one or more inter-unit channels in which the biological sample flows through the sub-equipment unit; (b) a first sorting unit capable of detecting a property of the biological sample at the microscopic level and sorting the biological sample by the detected property; (c) a first detection unit capable of detecting the same or different property of the sorted biological sample at the microscopic level, without sorting the biological sample; wherein the first sorting unit and the first detection unit are integrated into the first layer of material and positioned to be at least partially exposed in the inter-unit channel; and (d) a second sorting unit, wherein the biological sample flows by or through the first sorting unit before reaching the second sorting unit, and the second sorting unit is capable of detecting the same or different property of the biological sample as the first sorting unit and sorts the biological sample by the property it detects; and