An apparatus for positioning guidance for image acquisition, comprising: - an input unit; - a processing unit; and - an output unit; wherein the input unit is configured to receive an X-ray image of an anatomy of interest of a patient obtained from a first image acquisition and a target set of pose parameters describing a target position of the anatomy of interest for image acquisition; wherein the processing unit is configured to: - detect the anatomy of interest in the X-ray image, - determine a set of pose parameters describing a current position of the detected anatomy of interest in the first image acquisition, - determine a difference between the determined set of pose parameters and the target set of pose parameters, - construct a trajectory that defines a sequence of sets of pose parameters for bringing the anatomy of interest from the current position to the target position, if the difference is equal to or greater than a pre-defined threshold, and - generate a series of X-ray images according to the received X-ray image and the sequence of sets of pose parameters in the trajectory to synthesize a virtual fluoroscopic image sequence of frames representing an animated radiographic imaging during re-positioning of the patient; and wherein the output unit is configured to provide the synthetic virtual fluoroscopic image sequence for positioning guidance for a second image acquisition. - an input unit; - a processing unit; and - an output unit; wherein the input unit is configured to receive an X-ray image of an anatomy of interest of a patient obtained from a first image acquisition and a target set of pose parameters describing a target position of the anatomy of interest for image acquisition; wherein the processing unit is configured to: - detect the anatomy of interest in the X-ray image, - determine a set of pose parameters describing a current position of the detected anatomy of interest in the first image acquisition, - determine a difference between the determined set of pose parameters and the target set of pose parameters, - construct a trajectory that defines a sequence of sets of pose parameters for bringing the anatomy of interest from the current position to the target position, if the difference is equal to or greater than a pre-defined threshold, and - generate a series of X-ray images according to the received X-ray image and the sequence of sets of pose parameters in the trajectory to synthesize a virtual fluoroscopic image sequence of frames representing an animated radiographic imaging during re-positioning of the patient; and wherein the output unit is configured to provide the synthetic virtual fluoroscopic image sequence for positioning guidance for a second image acquisition. wherein the input unit is configured to receive an X-ray image of an anatomy of interest of a patient obtained from a first image acquisition and a target set of pose parameters describing a target position of the anatomy of interest for image acquisition; wherein the processing unit is configured to: - detect the anatomy of interest in the X-ray image, - determine a set of pose parameters describing a current position of the detected anatomy of interest in the first image acquisition, - determine a difference between the determined set of pose parameters and the target set of pose parameters, - construct a trajectory that defines a sequence of sets of pose parameters for bringing the anatomy of interest from the current position to the target position, if the difference is equal to or greater than a pre-defined threshold, and - generate a series of X-ray images according to the received X-ray image and the sequence of sets of pose parameters in the trajectory to synthesize a virtual fluoroscopic image sequence of frames representing an animated radiographic imaging during re-positioning of the patient; and - detect the anatomy of interest in the X-ray image, - determine a set of pose parameters describing a current position of the detected anatomy of interest in the first image acquisition, - determine a difference between the determined set of pose parameters and the target set of pose parameters, - construct a trajectory that defines a sequence of sets of pose parameters for bringing the anatomy of interest from the current position to the target position, if the difference is equal to or greater than a pre-defined threshold, and - generate a series of X-ray images according to the received X-ray image and the sequence of sets of pose parameters in the trajectory to synthesize a virtual fluoroscopic image sequence of frames representing an animated radiographic imaging during re-positioning of the patient; and wherein the output unit is configured to provide the synthetic virtual fluoroscopic image sequence for positioning guidance for a second image acquisition.