mhurhangee/ep-ind-claims huggingface dataset:
A compound comprising the general formula: X-L-[X-L] i -X, wherein i is an integer from 0 to 9, the value of which indicates the number of units of [X-L] i present in the compound, wherein each X is independently a targeting oligonucleotide of 7 to 16 nucleotides in length having a region of complementarity comprising at least 7 contiguous nucleotides complementary to a target region of an mRNA, and at least one targeting oligonucleotide is a single-stranded oligonucleotide and comprises phosphorothioate internucleotide linkages between at least two nucleotides, and each L is a linker that links at least two Xs and that is more susceptible to cleavage in a mammalian extract than each X, wherein when i=0, and the general formula is 5'X3'-L-5'X3' and when the target regions complementary to the first X and second X do not overlap in the mRNA, the 5 '-end of the target region complementary to the first X and the 3'-end of the target region complementary to the second X are not within a distance of 0 to 4 nucleotides in the mRNA, wherein at least one L is an oligonucleotide linker having a nucleotide sequence comprising from 1 to 10 thymidine or from 1 to 10 uridine nucleotides linked through phosphodiester internucleotide linkages, wherein at least one L does not comprise an oligonucleotide having a self-complementary nucleotide sequence, and wherein at least one L does not comprise an oligonucleotide having a nucleotide sequence that is complementary to a region of the mRNA that is contiguous with the target regions complementary to two immediately flanking Xs. wherein i is an integer from 0 to 9, the value of which indicates the number of units of [X-L] i present in the compound, wherein each X is independently a targeting oligonucleotide of 7 to 16 nucleotides in length having a region of complementarity comprising at least 7 contiguous nucleotides complementary to a target region of an mRNA, and at least one targeting oligonucleotide is a single-stranded oligonucleotide and comprises phosphorothioate internucleotide linkages between at least two nucleotides, and each L is a linker that links at least two Xs and that is more susceptible to cleavage in a mammalian extract than each X, wherein when i=0, and the general formula is 5'X3'-L-5'X3' and when the target regions complementary to the first X and second X do not overlap in the mRNA, the 5 '-end of the target region complementary to the first X and the 3'-end of the target region complementary to the second X are not within a distance of 0 to 4 nucleotides in the mRNA, wherein at least one L does not comprise an oligonucleotide having a self-complementary nucleotide sequence, and wherein at least one L does not comprise an oligonucleotide having a nucleotide sequence that is complementary to a region of the mRNA that is contiguous with the target regions complementary to two immediately flanking Xs.
A circuit for a charged particle detector (144; 244) comprising: a storage cell configured to receive a signal representing an output of a sensing element; a storage cell switch configured to selectively transmit the signal representing the output of the sensing element to the storage cell; a threshold detector including circuitry configured to determine an integration start signal based on a comparison of the signal representing the output of the sensing element to a threshold, and to determine an integration stop signal based on a comparison of the signal representing the output of the sensing element to a second threshold; and a converter including circuitry configured to perform signal processing on a signal transmitted from the storage cell. a storage cell configured to receive a signal representing an output of a sensing element; a storage cell switch configured to selectively transmit the signal representing the output of the sensing element to the storage cell; a threshold detector including circuitry configured to determine an integration start signal based on a comparison of the signal representing the output of the sensing element to a threshold, and to determine an integration stop signal based on a comparison of the signal representing the output of the sensing element to a second threshold; and a converter including circuitry configured to perform signal processing on a signal transmitted from the storage cell.
An apparatus for filling the basket of a portafilter of an espresso machine with a predetermined dose of coffee grounds and for pressing it within the portafilter, characterized in that it comprises a frame having a front wall, a support device for supporting the portafilter and upon which the portafilter is placed, a first emplacement, configured on said support, in which said portafilter is placed for filling a predetermined dose of coffee grounds in its basket, a conduit with its opening facing said first emplacement configured on the support, a dispenser device for dispensing coffee grounds and cause a predetermined dose of coffee grounds to reach the basket of the portafilter, through said conduit, a second emplacement, configured on said support, in which said portafilter is positioned with the basket filled with the predetermined dose of coffee grounds, upon displacement thereof from said first emplacement, a pressing device for pressing the coffee grounds, mechanical means (13, 14, 48) for supporting said pressing device, in a vertically aligned position above said second emplacement as well as motor means (52, 54, 55) for moving it toward and away from the dose of coffee grounds contained in the basket of the portafilter characterized in that the support device projects out of said front wall and in that said mechanical means (13, 14, 48) support said pressing device in cantilever fashion from said frame.
A spacer element configured to be used in an orthopedic or prosthetic device, the spacer element having first and second outer surfaces defined on opposed first and second sides, respectively, of the spacer element, the spacer element comprising: a three-dimensional knit fabric layer defining first and second fabric layers (91, 90) spaced by a ventilated and compressible core, the first fabric layer being a fabric mesh having a plurality of uniformly spaced apertures arranged in a pattern; and a discrete and continuous web-like frictional layer defined as a sheet of silicone elastomer laminated onto the first fabric layer, the frictional layer having a plurality of apertures arranged in a pattern, the pattern of the frictional layer apertures are in direct correspondence to the pattern of the first fabric layer apertures; characterized by a compressible material layer having opposed first and second surfaces, the compressible material layer first surface secured to the second fabric layer, the compressible material layer having a first compression molded region with reduced thickness (702, 704, 706, 708) and increased density relative to a second region of the compressible material layer having a predetermined thickness. a three-dimensional knit fabric layer defining first and second fabric layers (91, 90) spaced by a ventilated and compressible core, the first fabric layer being a fabric mesh having a plurality of uniformly spaced apertures arranged in a pattern; and a discrete and continuous web-like frictional layer defined as a sheet of silicone elastomer laminated onto the first fabric layer, the frictional layer having a plurality of apertures arranged in a pattern, the pattern of the frictional layer apertures are in direct correspondence to the pattern of the first fabric layer apertures; characterized by a compressible material layer having opposed first and second surfaces, the compressible material layer first surface secured to the second fabric layer, the compressible material layer having a first compression molded region with reduced thickness (702, 704, 706, 708) and increased density relative to a second region of the compressible material layer having a predetermined thickness.
A manufacturing method of carbon fiber rims, comprising: A. forming a metal strip having a needed shape by heating a metal substrate to a moldable temperature and then being extruded, wherein the metal strip comprises two side walls, a connecting wall connecting opposite terminal surfaces of the side walls, and an inner rim wall connecting the radial inner edges of the side walls to form a space surrounded by the side walls, the connecting wall and the inner rim wall; B. connecting two terminals of the strip to form a circle as a rim frame's embryo; C. forming through holes and spoke coupling holes by milling the rim frame's embryo to form a rim frame, wherein each spoke coupling hole was formed on the inner rim wall and at positions not corresponding to any through hole but between the adjacent two through holes, and each spoke coupling element is disposed in each spoke coupling hole; characterized in that the method further comprises the steps of D. performing a surface roughening treatment on the rim frame having the through holes and the spoke coupling holes thereon to increase roughness of a surface of the rim frame; E. covering a carbon fiber cloth by trimming the carbon fiber cloth to a suitable shape and then covering the rim frame and the through holes by the trimmed carbon fiber cloth; F. heatsetting the rim frame covered by the trimmed carbon fiber cloth in a model to form a carbon fiber layer on the rim frame and thus form a semi-finished carbon fiber rim; and G. treating a surface of the semi-finished carbon fiber rim to form a finishing carbon fiber rim of a bicycle. A. forming a metal strip having a needed shape by heating a metal substrate to a moldable temperature and then being extruded, wherein the metal strip comprises two side walls, a connecting wall connecting opposite terminal surfaces of the side walls, and an inner rim wall connecting the radial inner edges of the side walls to form a space surrounded by the side walls, the connecting wall and the inner rim wall; B. connecting two terminals of the strip to form a circle as a rim frame's embryo; C. forming through holes and spoke coupling holes by milling the rim frame's embryo to form a rim frame, wherein each spoke coupling hole was formed on the inner rim wall and at positions not corresponding to any through hole but between the adjacent two through holes, and each spoke coupling element is disposed in each spoke coupling hole; characterized in that the method further comprises the steps of D. performing a surface roughening treatment on the rim frame having the through holes and the spoke coupling holes thereon to increase roughness of a surface of the rim frame; E. covering a carbon fiber cloth by trimming the carbon fiber cloth to a suitable shape and then covering the rim frame and the through holes by the trimmed carbon fiber cloth; F. heatsetting the rim frame covered by the trimmed carbon fiber cloth in a model to form a carbon fiber layer on the rim frame and thus form a semi-finished carbon fiber rim; and G. treating a surface of the semi-finished carbon fiber rim to form a finishing carbon fiber rim of a bicycle.
A dielectric filter, comprising an integrally formed body made of a solid-state dielectric material wherein at least two dents are disposed on a surface of the integrally formed body; one or more of a hole (41, 42) and a groove provided in the integrally formed body are disposed between pairs of the at least two dents on the integrally formed body; and the surface of the integrally formed body is covered with a conducting layer, wherein surfaces of interiors of the one or more hole (41, 42) and groove are covered with the conducting layer; characterized in that the conducting layer of the interior of the groove and the conducting layer of the interior of the hole (41, 42) are partially removed for adjusting coupling between the dielectric resonators, and the conducting layer of the dent is partially removed for adjusting a resonance frequency of the dielectric filter.
An intraocular lens haptic (100, 200) comprising: a toroid portion having an outer diameter and an inner diameter and an interior volume, wherein the interior volume of the toroid portion is configured to be filled with a fluid; and a receiving feature (104, 204) extending from a central inner surface of the toroid portion; and the receiving feature adapted for concentrically retaining an intraocular lens optic. a toroid portion having an outer diameter and an inner diameter and an interior volume, wherein the interior volume of the toroid portion is configured to be filled with a fluid; and a receiving feature (104, 204) extending from a central inner surface of the toroid portion; and the receiving feature adapted for concentrically retaining an intraocular lens optic.
A device comprising: a light emitting device (1A, 1B) comprising a substrate and a semiconductor structure comprising a light emitting layer; a first reflective layer completely surrounding the light emitting device; a wavelength converting element disposed over the light emitting device; and a second reflective layer disposed adjacent a first sidewall of the wavelength converting element; wherein no reflective layer covers a second sidewall of the wavelength converting element. a light emitting device (1A, 1B) comprising a substrate and a semiconductor structure comprising a light emitting layer; a first reflective layer completely surrounding the light emitting device; a wavelength converting element disposed over the light emitting device; and a second reflective layer disposed adjacent a first sidewall of the wavelength converting element; wherein no reflective layer covers a second sidewall of the wavelength converting element.
A multi-layer structural component (60, 100) - with a layer structure comprising a plurality of layers (4, 6) arranged on top of one another in a stacking direction, - the layer structure comprising at least one fibre layer of a fibre material and of a thermoplastic binder, and at least one aluminium layer of aluminium or of an aluminium alloy, characterised in that - at least one aluminium layer of the layer structure has a reinforcing structure (50, 78, 94; 56, 74, 98)wherein the reinforcing structure is formed as a flanged edge (56, 74). - with a layer structure comprising a plurality of layers (4, 6) arranged on top of one another in a stacking direction, - the layer structure comprising at least one fibre layer of a fibre material and of a thermoplastic binder, and at least one aluminium layer of aluminium or of an aluminium alloy, - at least one aluminium layer of the layer structure has a reinforcing structure (50, 78, 94; 56, 74, 98)wherein the reinforcing structure is formed as a flanged edge (56, 74).
An implantable neurostimulator for treating chronic cardiac dysfunction, comprising: a pulse generator configured to deliver electrical therapeutic stimulation; and an integrated leadless heart rate sensor configured to sense and record heart rate while the electrical therapeutic stimulation is delivered by the pulse generator without influencing how the electric therapeutic stimulation is tuned and delivered; a memory storing stimulation parameters defining a periodic duty cycle comprising a percentage of time during which the pulse generator delivers the electrical therapeutic stimulation; wherein the duty cycle is between 5% to 30%. a pulse generator configured to deliver electrical therapeutic stimulation; and an integrated leadless heart rate sensor configured to sense and record heart rate while the electrical therapeutic stimulation is delivered by the pulse generator without influencing how the electric therapeutic stimulation is tuned and delivered; a memory storing stimulation parameters defining a periodic duty cycle comprising a percentage of time during which the pulse generator delivers the electrical therapeutic stimulation; wherein the duty cycle is between 5% to 30%.
A control module for controlling at least one insulated gate bipolar transistor, IGBT, device; the control module comprising at least one output arranged to be operably coupled to at least one IGBT driver module for the at least one IGBT device; the control module being arranged to receive a first IGBT control signal indicating a required operating state of the at least one IGBT device and at least one further IGBT control signal; wherein the control module is further arranged to, upon the first IGBT control signal indicating a required change in operating state of the at least one IGBT device: (i) control the at least one IGBT driver module to change an operating state of the at least one IGBT device by applying a first logical state modulation at the output thereof; and (ii) apply at least one further modulation to the logical state at the output thereof in accordance with the at least one further IGBT control signal within a time period from the first logical state transition, the time period being less than a state change reaction period Δt for the at least one IGBT device. (i) control the at least one IGBT driver module to change an operating state of the at least one IGBT device by applying a first logical state modulation at the output thereof; and (ii) apply at least one further modulation to the logical state at the output thereof in accordance with the at least one further IGBT control signal within a time period from the first logical state transition, the time period being less than a state change reaction period Δt for the at least one IGBT device.
A steel joist assembly for use in association with a concrete slab to form a composite steel joist comprising a steel joist having a top portion with a generally planar top surface and a planar web generally orthogonal to the generally planar top surface wherein the generally planar top surface of the steel joist is generally coplanar with the generally planar top surface of a support member; a pair of end connectors, one attached at each end of the steel joist and extending outwardly therefrom each end connector having a diagonal member, characterized in that each end connector has a strut and a shoe, the strut has a generally planar bottom surface which is attached to a portion of the generally planar top surface of the steel joist, the shoe being attached to the distal end of the strut and the diagonal member is attached at one end thereof to the strut and at the other end thereof to a portion of the planar web of the steel joist. a steel joist having a top portion with a generally planar top surface and a planar web generally orthogonal to the generally planar top surface wherein the generally planar top surface of the steel joist is generally coplanar with the generally planar top surface of a support member; a pair of end connectors, one attached at each end of the steel joist and extending outwardly therefrom each end connector having a diagonal member, characterized in that each end connector has a strut and a shoe, the strut has a generally planar bottom surface which is attached to a portion of the generally planar top surface of the steel joist, the shoe being attached to the distal end of the strut and the diagonal member is attached at one end thereof to the strut and at the other end thereof to a portion of the planar web of the steel joist.
Medical pressure measuring device for measuring a pressure of a pressurized breathing gas supplied to a subject by a breathing apparatus, the device comprising: - a pressure sensor arranged at a point of measurement, wherein the pressure sensor is configured to measure the pressure of a sample gas at a sampling point, wherein the sampling point and the point of measurement are connected by a pressure sampling tube so that a pressure wave of the sample gas is able to propagate from the sampling point to the point of measurement, wherein the pressure sampling tube has a sampling tube volume and an acoustic impedance, characterised in that the medical pressure measuring device further comprises - a damping arrangement arranged to be brought into fluid communication with the pressure sampling tube, wherein the damping arrangement comprises a flow restrictor and an associated receptor chamber arrangement, wherein the receptor chamber arrangement comprises a receptor chamber for receiving the pressure wave of the sample gas, and the flow restrictor correlates to the acoustic impedance of the pressure sampling tube and the receptor chamber correlates at least to the volume of the pressure sampling tube, so as to prevent acoustic resonance in the pressure sampling tube from affecting pressure measurements made by the pressure sensor. - a pressure sensor arranged at a point of measurement, wherein the pressure sensor is configured to measure the pressure of a sample gas at a sampling point, wherein the sampling point and the point of measurement are connected by a pressure sampling tube so that a pressure wave of the sample gas is able to propagate from the sampling point to the point of measurement, wherein the pressure sampling tube has a sampling tube volume and an acoustic impedance, - a damping arrangement arranged to be brought into fluid communication with the pressure sampling tube, wherein the damping arrangement comprises a flow restrictor and an associated receptor chamber arrangement, wherein the receptor chamber arrangement comprises a receptor chamber for receiving the pressure wave of the sample gas, and the flow restrictor correlates to the acoustic impedance of the pressure sampling tube and the receptor chamber correlates at least to the volume of the pressure sampling tube, so as to prevent acoustic resonance in the pressure sampling tube from affecting pressure measurements made by the pressure sensor.
A method of processing adaptive audio content, comprising: determining an audio type as one of channel-based audio and object-based audio for each audio segment of an adaptive audio bitstream comprising a plurality of audio segments; tagging the each audio segment with a metadata definition indicating the audio type of the corresponding audio segment; processing audio segments tagged as channel-based audio in a channel audio renderer component; processing audio segments tagged as object-based audio in an object audio renderer component that is distinct from the channel audio renderer component, wherein the channel audio renderer component and the object audio renderer component have non-zero and differing latencies, characterized in that both of said renderer components are queried for their respective latency in samples upon their first initialization for managing latency and synchronization when switching between processing object-based audio segments and channel-based audio segments. determining an audio type as one of channel-based audio and object-based audio for each audio segment of an adaptive audio bitstream comprising a plurality of audio segments; tagging the each audio segment with a metadata definition indicating the audio type of the corresponding audio segment; processing audio segments tagged as channel-based audio in a channel audio renderer component; processing audio segments tagged as object-based audio in an object audio renderer component that is distinct from the channel audio renderer component, wherein the channel audio renderer component and the object audio renderer component have non-zero and differing latencies,
A device for disinfecting or treating cows' claws fully automatically consisting of a fluid-filled mat, made from springy material with the characteristic that this mat is connected through a pipe to a water supply system so it can be filled with water, whereby with a dosing pump and from a container a disinfectant or medicine is added to the water and whereby the pipe has been provided with a pressure reducing valve to make sure the mat is continuously filled with the disinfecting solution or medicine at the right pressure and whereby the mat is provided with hemispherical bulges protruding at regular intervals which at the upper side have a valve and sprayer so that whenever a cow steps onto the elastic hemispherical bulge, the valve stem at the bottom side of the mat is pushed in, the valve opens up, the sprayer is activated and the claw is sprayed.