A compound according to formula I for the use in treating angiogenesis mediated diseases selected from a solid tumor, macular degeneration or inflammatory/immune disease, wherein said inflammatory/immune disease is Crohn's disease, inflammatory bowel disease, Sjögren's syndrome, asthma, organ transplant rejection, systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, psoriasis or multiple sclerosis: wherein ring A is benzene; ring B is pyridine; carbocycle is a mono-, bi-, or tricyclic aliphatic ring having 3 to 14 carbon atoms which is saturated or unsaturated, aromatic or non-aromatic; heterocycle is a mono-, bi-, or tricyclic, saturated or unsaturated, aromatic or non-aromatic ring having from 5 to about 14 ring atoms, where the ring atoms are 1 to 4 nitrogen, sulfur or oxygen heteroatoms and the balance carbon atoms; R 1 is hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl or sulfonamide; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl and sulfonamide substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; or R 1 is a carbocycle or a heterocycle, as defined above, that is optionally substituted with hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, a carbocycle or heterocycle, as defined above; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; R 2 is hydrogen; R 3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle, as defined above, wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, sulfonyl or alkoxy; each R 4 is independently H or alkyl; R 5 is chloro; m is 0-3; n is 0-4; or a salt or solvate thereof. ring A is benzene; ring B is pyridine; carbocycle is a mono-, bi-, or tricyclic aliphatic ring having 3 to 14 carbon atoms which is saturated or unsaturated, aromatic or non-aromatic; heterocycle is a mono-, bi-, or tricyclic, saturated or unsaturated, aromatic or non-aromatic ring having from 5 to about 14 ring atoms, where the ring atoms are 1 to 4 nitrogen, sulfur or oxygen heteroatoms and the balance carbon atoms; R 1 is hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl or sulfonamide; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl and sulfonamide substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; or R 1 is a carbocycle or a heterocycle, as defined above, that is optionally substituted with hydroxyl, halogen, amino, nitro, cyano, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, a carbocycle or heterocycle, as defined above; wherein said amino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, carbamoyl, acylamine, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, oxo, or is substituted with a carbocycle or heterocycle, as defined above, that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; R 2 is hydrogen; R 3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle, as defined above, wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, sulfonyl or alkoxy; each R 4 is independently H or alkyl; R 5 is chloro; m is 0-3; n is 0-4; or a salt or solvate thereof.