mhurhangee/ep-ind-claims huggingface dataset:
A fluorine-containing pyrimidine compound represented by a general formula,,,,, or below: wherein, in the general formulae to above, R represents a hydrocarbon group having 1 to 12 carbon atoms, and X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, -C n F 2n+1 (n is an integer of 1 to 10), a nitro group, a boronate group, -OA 1, -SO m A 1 (m is an integer of 0 to 3), -NA 1 A 2, -COOA 1, or -CONA 1 A 2, and A 1 and A 2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms. R represents a hydrocarbon group having 1 to 12 carbon atoms, and X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, -C n F 2n+1 (n is an integer of 1 to 10), a nitro group, a boronate group, -OA 1, -SO m A 1 (m is an integer of 0 to 3), -NA 1 A 2, -COOA 1, or -CONA 1 A 2, and A 1 and A 2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms.
An applicator device, comprising: a body having a lumen for receiving an antiseptic agent, the lumen defining a reservoir containing the antiseptic agent, wherein the lumen is sealed at a distal extremity and a proximal extremity thereof following receipt of the antiseptic agent; a pad coupled to a distal end of the body; and a defeatable barrier interposedly positioned between the reservoir and the pad, wherein upon defeating the barrier, the reservoir and the pad are in fluid communication; characterized by a pinching actuator coupled adjacent the distal end of the body between the body and the pad, wherein the pinching actuator is configured to defeat the defeatable barrier upon actuation. a body having a lumen for receiving an antiseptic agent, the lumen defining a reservoir containing the antiseptic agent, wherein the lumen is sealed at a distal extremity and a proximal extremity thereof following receipt of the antiseptic agent; a pad coupled to a distal end of the body; and a defeatable barrier interposedly positioned between the reservoir and the pad, wherein upon defeating the barrier, the reservoir and the pad are in fluid communication; characterized by a pinching actuator coupled adjacent the distal end of the body between the body and the pad, wherein the pinching actuator is configured to defeat the defeatable barrier upon actuation.
An antisense morpholino oligomer for use in a method of treating a bacterial infection by reducing expression and activity of a protein associated with a biochemical pathway and/or cellular process in a bacterium, wherein the bacterium is in a subject and is selected from the genus Klebsiella, and the protein is an acyl carrier protein encoded by the acpP gene, said method comprising contacting the bacterium with an antisense morpholino oligomer, wherein the antisense morpholino oligomer is composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5'-exocyclic carbon of an adjacent subunit, and having (a) 10-40 nucleotide bases, and (b) a targeting sequence of SEQ ID NO: 2 (TGC TCA TAC TC), where the oligomer is conjugated to a cell-penetrating peptide.
A shaving head for a shaving apparatus comprising a main housing accommodating a motor, the shaving head comprising: - a support structure including a coupling structure for coupling the shaving head to the main housing of the shaving apparatus; - a shaving unit comprising a shaving unit frame and a skin contacting face and at least two cutting units each having an external cutting member and an internal cutting member which is rotatable relative to the external cutting member; - a pivot structure (44, 46) for allowing the shaving unit to pivot relative to the support structure; - a central driving member arranged to be driven by the motor when the shaving head is coupled to the main housing; wherein each internal cutting member is rotatable by the central driving member via a separate cutter driving member, the central driving member transmitting a driving force to each cutter driving member in a transmission location; and wherein the pivot structure is located in an internal area of the shaving head located between the skin contacting face, the cutter driving members and the transmission locations of the central driving member; characterized in that the central driving member and the cutter driving members each have a bearing (48, 261) which is connected to the shaving unit frame to allow the central driving member and the cutter driving members to pivot together with the shaving unit relative to the support structure. - a support structure including a coupling structure for coupling the shaving head to the main housing of the shaving apparatus; - a shaving unit comprising a shaving unit frame and a skin contacting face and at least two cutting units each having an external cutting member and an internal cutting member which is rotatable relative to the external cutting member; - a pivot structure (44, 46) for allowing the shaving unit to pivot relative to the support structure; - a central driving member arranged to be driven by the motor when the shaving head is coupled to the main housing;
A tire for which a mounting direction to a vehicle is specified, comprising: a tread portion having a first tread edge and a second tread edge to be positioned outboard and inboard, respectively, of the vehicle, wherein the tread portion is provided with four circumferential grooves extending continuously in the tire circumferential direction so as to axially divide the tread portion into five land portions, the five land portions are a first shoulder land portion including the first tread edge, a second shoulder land portion including the second tread edge, a first middle land portion adjacent to the first shoulder land portion, a second middle land portion adjacent to the second shoulder land portion, and a crown land portion between the first middle land portion and the second middle land portion, and each of the five land portions is provided with sipes, characterized in that under a 50% load state of the tire defined such that the tire mounted on a normal rim and inflated to a normal pressure is contacted with a flat horizontal plane at a camber angle of 0 degree and loaded with 50% of a normal tire load, axial widths W1s, W1m, Wc, W2m and W2s of ground contacting surfaces of the first shoulder land portion, the first middle land portion, the crown land portion, the second middle land portion, and the second shoulder land portion, respectively, satisfy the following condition: W1s > W1m > Wc > W2m ≧ W2s. the tread portion is provided with four circumferential grooves extending continuously in the tire circumferential direction so as to axially divide the tread portion into five land portions, the five land portions are a first shoulder land portion including the first tread edge, a second shoulder land portion including the second tread edge, a first middle land portion adjacent to the first shoulder land portion, a second middle land portion adjacent to the second shoulder land portion, and a crown land portion between the first middle land portion and the second middle land portion, and each of the five land portions is provided with sipes, characterized in that under a 50% load state of the tire defined such that the tire mounted on a normal rim and inflated to a normal pressure is contacted with a flat horizontal plane at a camber angle of 0 degree and loaded with 50% of a normal tire load, axial widths W1s, W1m, Wc, W2m and W2s of ground contacting surfaces of the first shoulder land portion, the first middle land portion, the crown land portion, the second middle land portion, and the second shoulder land portion, respectively, satisfy the following condition: W1s > W1m > Wc > W2m ≧ W2s.
A data center infrastructure management 'DCIM' system having an infrastructure control fabric 'ICF' subsystem for enabling a manager component of an independent computing device to communicate directly with the DCIM system, the DCIM system including: a manageability subsystem engine for monitoring data being transmitted from the independent computing device, a domain model that includes a domain model extension relating to information on the independent computing device; and a services server for providing a shared services infrastructure layer, wherein the ICF subsystem includes components located in the manageability subsystem engine, in the domain model and in the services server, to enable the manager component of the independent computing device to directly query the DCIM system, the query being transparent to a user, to obtain at least one of real time power, cooling and space information that is useful for the independent computing device to know before at least one of initiating an operation or continuing with an operation, wherein the components of the ICF subsystem include an element library in the manageability subsystem engine that has information on the independent computing device and is configured to assist in enabling the manager component of the independent computing device to directly query the DCIM system, wherein the independent computing device is able to communicate directly with the DCIM system using the ICF subsystem. a manageability subsystem engine for monitoring data being transmitted from the independent computing device, a domain model that includes a domain model extension relating to information on the independent computing device; and a services server for providing a shared services infrastructure layer, wherein the ICF subsystem includes components located in the manageability subsystem engine, in the domain model and in the services server, to enable the manager component of the independent computing device to directly query the DCIM system, the query being transparent to a user, to obtain at least one of real time power, cooling and space information that is useful for the independent computing device to know before at least one of initiating an operation or continuing with an operation, wherein the components of the ICF subsystem include an element library in the manageability subsystem engine that has information on the independent computing device and is configured to assist in enabling the manager component of the independent computing device to directly query the DCIM system, wherein the independent computing device is able to communicate directly with the DCIM system using the ICF subsystem.
Method for increasing the temperature homogeneity in a pit furnace (200;300), in which at least two ingots (201;301) to be heated are caused to lean against a respective one of first and second opposite inner walls of the pit furnace (200;300) so that the ingots (201;301) form an elongated space (203;303) having a V-shaped cross-section between them as seen along the first and second walls, characterised in that at least one separate lance (211,212,221,222;311,312,321,322) for an oxidant with an oxygen content of at least 85 percentages by weight and at least one separate lance (210,220;310,320) for fuel are caused to be arranged in a furnace wall with their orifices arranged opening out into the furnace (200;300) at a distance from each other and so that oxidant and fuel, respectively, are caused to be suppliable to said V-shaped space (203;303) and to be combustible therein, and in that the orifice of the lance (211,212,221,222;311,312,321,322) for oxidant is caused to be arranged above the orifice of the fuel lance (210,220;310,320) and to be directed so that the oxidant flows obliquely downwards and along the longitudinal direction of said V-shaped space (203;303).
Bone screw for fixing a connection support to a bone, with a screw head, which has a head thread for producing a threaded connection to the connection support, with a shank, which has a bone thread for engaging in the bone substance, and with a transition area between the screw head and the shank, the bone screw having on its surface a hard coating (17, 18) which has a greater hardness than the coated material, characterized in that the coating has a lesser thickness in the area of the screw head than in the area of the shank.
A liposome preparation comprising a drug encapsulated in a liposome composition, wherein the liposome composition is obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained in a total concentration of 100 to 200 w/v% in an alcohol solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution, thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v%, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution, wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane, the internal-region aqueous phase including the first aqueous phase solution, and an aqueous phase in an external region of the liposome membrane, the external-region aqueous phase including the second aqueous phase solution, wherein the liposome has the internal-region aqueous phase inside a multilayer membrane having at least 12 layered structures, and wherein the drug is introduced into the aqueous phase in the internal region in the liposome composition by use of the ion gradient.
An optical fiber cable incorporating a plurality of multi-core fibers, each of the multi-core fibers comprising a plurality of cores (110A, 110B1, 110B2, 110B3, 110C1, 110C2, 110C3) each extending along a predetermined axis, and a cladding region integrally surrounding the plurality of cores, characterized in that: the optical fiber cable is provided with a structure for maintaining the multi-core optical fibers in a bend state having a maximum radius of curvature R lower than R th as defined by the following expression: R th = 1 2 β κ 2 D nm XT S L F where D nm is an intercentral distance between core n and core m in each multi-core fiber, L F a fiber length of each multi-core fiber corresponding to a length between repeater/regenerators in laying the optical fiber cable, β a propagation constant of each core at the first wavelength, κ a coupling coefficient between adjacent cores at the first wavelength, and XT S a maximum value permitted as an average of a distribution of crosstalk after propagation of light of the first wavelength through the fiber length L F, wherein XT S is equal to 0.001 and L F is equal to 100km or more. the optical fiber cable is provided with a structure for maintaining the multi-core optical fibers in a bend state having a maximum radius of curvature R lower than R th as defined by the following expression: R th = 1 2 β κ 2 D nm XT S L F where D nm is an intercentral distance between core n and core m in each multi-core fiber, L F a fiber length of each multi-core fiber corresponding to a length between repeater/regenerators in laying the optical fiber cable, β a propagation constant of each core at the first wavelength, κ a coupling coefficient between adjacent cores at the first wavelength, and XT S a maximum value permitted as an average of a distribution of crosstalk after propagation of light of the first wavelength through the fiber length L F, wherein XT S is equal to 0.001 and L F is equal to 100km or more.
A simulation system, comprising: a body; a linear motor attached to the body, the linear motor having at least two independently controllable magnetic coils and a sliding mass having at least one magnet for magnetically interacting with at least one of the at least two magnetic coils; a controller that controls movement of the sliding mass by controlling a current in one or more of the at least two magnetic coils such that the sliding mass produces a force on the body that simulates a haptic effect; a mechanical stop, wherein the sliding mass is driven against the mechanical stop to simulate the haptic effect, characterised in that the mechanical stop is adjustable such that the angle of impact of the sliding mass is changed such that a different simulation effect is felt by a user. a body; a linear motor attached to the body, the linear motor having at least two independently controllable magnetic coils and a sliding mass having at least one magnet for magnetically interacting with at least one of the at least two magnetic coils; a controller that controls movement of the sliding mass by controlling a current in one or more of the at least two magnetic coils such that the sliding mass produces a force on the body that simulates a haptic effect; a mechanical stop, wherein the sliding mass is driven against the mechanical stop to simulate the haptic effect,
A chewing gum comprising: a) a water-insoluble gum base comprising polyolefin thermoplastic elastomer; b) a water soluble bulk portion; and c) a flavour. a) a water-insoluble gum base comprising polyolefin thermoplastic elastomer; b) a water soluble bulk portion; and c) a flavour.
Separator for separating liquid droplets from an aerosol, in particular an oil separator for the crankcase ventilation gases of a reciprocating internal combustion engine, comprising a rotor arranged in a stationary housing and capable of being driven in rotation about a rotor axis, said rotor comprising a plurality of disks which are concentric with the rotor axis and are arranged parallel to one another, said disks together forming a stack of disks capable of being driven in rotation about the rotor axis and being arranged at in particular equal distances relative to one another in a direction of the rotor axis, a gas flow path between a dirty gas inlet of the separator for a gas entraining liquid droplets to be separated and a clean gas outlet of the separator for the gas cleaned, at least to a large extent, of the liquid droplets, a liquid outlet for discharging separated liquid from the housing, and an annular space between the circumference of the rotor and a circumferential wall of the housing enclosing the rotor, wherein the liquid outlet is in communication with the annular space and disks adjacent to each other in each case form therebetween an interspace that is concentric with the rotor axis and through which the gas is to flow, the radially outer area of said interspace opening into the annular space, wherein one of the dirty gas inlet and the clean gas outlet is in communication with the annular space and the other one of the dirty gas inlet and the clean gas outlet is in communication with radially inner areas of the interspaces, wherein at least in a plurality of the interspaces between two disk bodies adjacent to each other there are provided in each case a plurality of channels adjacent to one another and allowing passage therethrough of the gas to be cleaned, wherein each channel extends at least substantially from a first radial area to a second radial area, radially spaced from the first radial area, of the interspace, and wherein each channel is curved when viewed in a direction of the rotor axis, characterized in that the disks have flat disk bodies which extend in planes perpendicular to the rotor axis and in that between channel wall surfaces bounding the channel width on either side, the radially outer one forms an impaction and separation surface for the liquid droplets entrained by the gas to be cleaned.
An apparatus for controlling power supply of a plurality of load devices (20-1 to 20-n), said apparatus being adapted to determine a total power consumption of said plurality of load devices (20-1 to 20-n), to generate power change commands with power change information based on a comparison of said determined total power consumption with a target value, to broadcast said power change commands via a communication medium to said plurality of load devices (20-1 to 20-n) in a stepwise procedure that is converging towards the lower value of said target value and a sum of desired power values of said plurality of load devices (20-1 to 20-n).
A surgical instrument circuit for a surgical instrument connectable to a surgical energy module, the surgical energy module configured to provide a first electrical drive signal at a first frequency range for driving a first energy modality and a second electrical drive signal at a second frequency range for driving a second energy modality, the surgical instrument comprising a component configured to receive power from a direct current power source and an end effector, the surgical instrument circuit configured to: receive the first electrical drive signal from the surgical energy module; convert the first electrical drive signal to a DC voltage; apply the DC voltage to the surgical instrument component; receive the second electrical drive signal from the surgical energy module; and deliver the second energy modality to the end effector according to the second electrical signal; determine that the first energy modality is not delivered by the surgical instrument via a control circuit and, if the first energy modality is not delivered by the surgical instrument, convert the first drive signal to the DC output voltage by rerouting the first drive signal to a rectifier, further comprising the rectifier configured to convert the first electrical drive signal to the DC output voltage. receive the first electrical drive signal from the surgical energy module; convert the first electrical drive signal to a DC voltage; apply the DC voltage to the surgical instrument component; receive the second electrical drive signal from the surgical energy module; and deliver the second energy modality to the end effector according to the second electrical signal; determine that the first energy modality is not delivered by the surgical instrument via a control circuit and, if the first energy modality is not delivered by the surgical instrument, convert the first drive signal to the DC output voltage by rerouting the first drive signal to a rectifier, further comprising the rectifier configured to convert the first electrical drive signal to the DC output voltage.