An air-conditioning apparatus (100, 200, 300, 400) comprising: a heat-source-side refrigerant cycle in which a compressor, an outdoor heat exchanger, a plurality of intermediate heat exchangers (21, 22), and a first refrigerant flow control device functioning as an expansion valve and disposed between each of the intermediate heat exchangers (21, 22) are connected in series; and a plurality of use-side refrigerant cycles in which a plurality of indoor heat exchangers are connected in parallel with the plurality of intermediate heat exchangers (21, 22), respectively, wherein the compressor and the outdoor heat exchanger are disposed in an outdoor unit; the indoor heat exchanger is disposed in each of the plurality of indoor units; wherein each of the plurality of intermediate heat exchangers (21, 22) exchanges heat between a heat-source-side refrigerant circulating through the heat-source-side refrigerant cycle and a use-side refrigerant circulating through the use-side refrigerant cycle characterized in that a first bypass pipe which bypasses the first refrigerant flow control device through a first opening/closing device is disposed in the heat-source-side refrigerant cycle, the plurality of intermediate heat exchangers (21, 22), the first refrigerant flow control device, the first bypass pipe, and the first opening/closing device are disposed in a relay unit, and wherein the air-conditioning apparatus (100, 200, 300, 400) further comprises in the heat-source-side refrigerant cycle a second refrigerant flow control device disposed in the inlet side of an intermediate heat exchanger located in the upstream position among the plurality of intermediate heat exchangers; a second bypass pipe which bypasses the second refrigerant flow control device through a second opening/closing device; a third refrigerant flow control device disposed in the outlet side of an intermediate heat exchanger located on the downstream side among the plurality of intermediate heat exchangers; and a third bypass pipe which bypasses the third refrigerant flow control device through a third opening/closing device, wherein the second and third refrigerant flow control devices (25b, 25c) function as expansion valves. a heat-source-side refrigerant cycle in which a compressor, an outdoor heat exchanger, a plurality of intermediate heat exchangers (21, 22), and a first refrigerant flow control device functioning as an expansion valve and disposed between each of the intermediate heat exchangers (21, 22) are connected in series; and a plurality of use-side refrigerant cycles in which a plurality of indoor heat exchangers are connected in parallel with the plurality of intermediate heat exchangers (21, 22), respectively, wherein the compressor and the outdoor heat exchanger are disposed in an outdoor unit; the indoor heat exchanger is disposed in each of the plurality of indoor units; wherein each of the plurality of intermediate heat exchangers (21, 22) exchanges heat between a heat-source-side refrigerant circulating through the heat-source-side refrigerant cycle and a use-side refrigerant circulating through the use-side refrigerant cycle characterized in that a first bypass pipe which bypasses the first refrigerant flow control device through a first opening/closing device is disposed in the heat-source-side refrigerant cycle, the plurality of intermediate heat exchangers (21, 22), the first refrigerant flow control device, the first bypass pipe, and the first opening/closing device are disposed in a relay unit, and wherein the air-conditioning apparatus (100, 200, 300, 400) further comprises in the heat-source-side refrigerant cycle a second refrigerant flow control device disposed in the inlet side of an intermediate heat exchanger located in the upstream position among the plurality of intermediate heat exchangers; a second bypass pipe which bypasses the second refrigerant flow control device through a second opening/closing device; a third refrigerant flow control device disposed in the outlet side of an intermediate heat exchanger located on the downstream side among the plurality of intermediate heat exchangers; and a third bypass pipe which bypasses the third refrigerant flow control device through a third opening/closing device, wherein the second and third refrigerant flow control devices (25b, 25c) function as expansion valves.