A standalone radiopharmaceutical preparation hotcell for preparing a radiopharmaceutical, said hotcell comprising: a housing; a plurality of compartments defined within the housing, the plurality of compartments including at least a pharmaceutical synthesizing and dispensing compartment and a different second compartment (22, 24, 26, 28), the housing separating the plurality of compartments from an external environment surrounding the hotcell, wherein a plurality of walls are installed within housing to form said plurality of compartments and wherein an intercompartment door (30, 32, 34, 36) or hatch is installed between the pharmaceutical synthesizing and dispensing compartment and the different second compartment (22, 24, 26, 28); a compartment pressurization system configured to maintain the synthesizing and dispensing compartment at a first pressure and maintain the second compartment (22, 24, 26, 28) at a different second pressure, wherein the first pressure is greater than the second pressure, the compartment pressurization system including a ducting system (102, 110); a first compartment pressure sensor configured to determine a current pressure of the synthesizing and dispensing compartment and a second compartment pressure sensor configured to determine a current pressure of the second compartment (22, 24, 26, 28); and a controller configured to operate at least one of a valve (130, 132, 134, 136, 138) of the compartment pressurization system or a fan (104, 112) of the compartment pressurization system, based on the current pressures, to maintain the synthesizing and dispensing compartment and the second compartment (22, 24, 26, 28) at the first and second pressures. a housing; a plurality of compartments defined within the housing, the plurality of compartments including at least a pharmaceutical synthesizing and dispensing compartment and a different second compartment (22, 24, 26, 28), the housing separating the plurality of compartments from an external environment surrounding the hotcell, wherein a plurality of walls are installed within housing to form said plurality of compartments and wherein an intercompartment door (30, 32, 34, 36) or hatch is installed between the pharmaceutical synthesizing and dispensing compartment and the different second compartment (22, 24, 26, 28); a compartment pressurization system configured to maintain the synthesizing and dispensing compartment at a first pressure and maintain the second compartment (22, 24, 26, 28) at a different second pressure, wherein the first pressure is greater than the second pressure, the compartment pressurization system including a ducting system (102, 110); a first compartment pressure sensor configured to determine a current pressure of the synthesizing and dispensing compartment and a second compartment pressure sensor configured to determine a current pressure of the second compartment (22, 24, 26, 28); and a controller configured to operate at least one of a valve (130, 132, 134, 136, 138) of the compartment pressurization system or a fan (104, 112) of the compartment pressurization system, based on the current pressures, to maintain the synthesizing and dispensing compartment and the second compartment (22, 24, 26, 28) at the first and second pressures.