A bisindole of formula: wherein: R 1, R 3, R 4, R 5, R 7 and R 8 are hydrogen, R 2, R 6, R 9, and R 10 are substituents independently selected from the group consisting of hydrogen, C 1 -C 24 alkyl, C 2 -C 24 alkenyl, C 2 -C 24 alkynyl, C 5 -C 20 aryl, C 6 -C 24 alkaryl, C 6 -C 24 aralkyl, halo, hydroxyl, sulfhydryl, C 1 -C 24 alkoxy, C 2 -C 24 alkenyloxy, C 2 -C 24 alkynyloxy, C 5 -C 20 aryloxy, acyl, acyloxy, C 2 -C 24 alkoxycarbonyl, C 6 -C 20 aryloxycarbonyl, C 2 -C 24 alkylcarbonyl, C 6 -C 20 arylcarbonyl, halocarbonyl, C 2 -C 24 alkylcarbonato, C 6 -C 20 arylcarbonato, carboxy, carboxylato, carbamoyl, mono-(C 1 -C 24 alkyl)- substituted carbamoyl, di-(C 1 -C 24 alkyl)-substituted carbamoyl, mono-substituted arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, dihydroxyboryl, di-(C 1 -C 24)-alkoxyboryl, isothiocyanato, azido, formyl, thioformyl, amino, mono- and di-(C 1 -C 24 alkyl)-substituted amino, mono- and di-(C 5 -C 20 aryl)-substituted amino, C 2 -C 24 alkylamido, C 6 -C 20 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C 1 -C 24 alkylsulfanyl, arylsulfanyl, C 1 -C 24 alkylsulfinyl, C 5 -C 20 arylsulfinyl, C 1 -C 24 alkylsulfonyl, C 5 -C 20 arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, phosphino, and combinations thereof, and further wherein any two adjacent (ortho) substituents selected from R 1, R 2, R 3, R 4, R 5, R 6, R 7, and R 8 may be linked to form a cyclic structure selected from five-membered rings, six-membered rings, and fused five-membered and/or six-membered rings, wherein the cyclic structure is aromatic, alicyclic, heteroaromatic, or heteroalicyclic, and has zero to 4 non-hydrogen substituents and zero to 3 heteroatoms; and R 11 and R 12 are independently selected from the group consisting of hydrogen, formyl, C 1 -C 24 alkyl, C 6 -C 24 aralkyl, C 2 -C 24 alkoxycarbonyl, amino-substituted C 1 -C 24 alkyl, (C 1 - C 24 alkylamino)-substituted C 1 -C 24 alkyl, and di-(C 1 -C 24 alkyl)amino-substituted C 1 -C 24 alkyl; or a salt thereof, for use in the treatment of a disease associated with pathogenic lipoxygenase activity, other than a bacterial or viral infection, cancer or estrogen-dependent disorder, wherein the disease is a neurodegenerative disease. R 1, R 3, R 4, R 5, R 7 and R 8 are hydrogen, R 2, R 6, R 9, and R 10 are substituents independently selected from the group consisting of hydrogen, C 1 -C 24 alkyl, C 2 -C 24 alkenyl, C 2 -C 24 alkynyl, C 5 -C 20 aryl, C 6 -C 24 alkaryl, C 6 -C 24 aralkyl, halo, hydroxyl, sulfhydryl, C 1 -C 24 alkoxy, C 2 -C 24 alkenyloxy, C 2 -C 24 alkynyloxy, C 5 -C 20 aryloxy, acyl, acyloxy, C 2 -C 24 alkoxycarbonyl, C 6 -C 20 aryloxycarbonyl, C 2 -C 24 alkylcarbonyl, C 6 -C 20 arylcarbonyl, halocarbonyl, C 2 -C 24 alkylcarbonato, C 6 -C 20 arylcarbonato, carboxy, carboxylato, carbamoyl, mono-(C 1 -C 24 alkyl)- substituted carbamoyl, di-(C 1 -C 24 alkyl)-substituted carbamoyl, mono-substituted arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, dihydroxyboryl, di-(C 1 -C 24)-alkoxyboryl, isothiocyanato, azido, formyl, thioformyl, amino, mono- and di-(C 1 -C 24 alkyl)-substituted amino, mono- and di-(C 5 -C 20 aryl)-substituted amino, C 2 -C 24 alkylamido, C 6 -C 20 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C 1 -C 24 alkylsulfanyl, arylsulfanyl, C 1 -C 24 alkylsulfinyl, C 5 -C 20 arylsulfinyl, C 1 -C 24 alkylsulfonyl, C 5 -C 20 arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, phosphino, and combinations thereof, and further wherein any two adjacent (ortho) substituents selected from R 1, R 2, R 3, R 4, R 5, R 6, R 7, and R 8 may be linked to form a cyclic structure selected from five-membered rings, six-membered rings, and fused five-membered and/or six-membered rings, wherein the cyclic structure is aromatic, alicyclic, heteroaromatic, or heteroalicyclic, and has zero to 4 non-hydrogen substituents and zero to 3 heteroatoms; and R 11 and R 12 are independently selected from the group consisting of hydrogen, formyl, C 1 -C 24 alkyl, C 6 -C 24 aralkyl, C 2 -C 24 alkoxycarbonyl, amino-substituted C 1 -C 24 alkyl, (C 1 - C 24 alkylamino)-substituted C 1 -C 24 alkyl, and di-(C 1 -C 24 alkyl)amino-substituted C 1 -C 24 alkyl; or a salt thereof, for use in the treatment of a disease associated with pathogenic lipoxygenase activity, other than a bacterial or viral infection, cancer or estrogen-dependent disorder, wherein the disease is a neurodegenerative disease.