mhurhangee/ep-ind-claims huggingface dataset:
A hearing system, comprising: a medial ear canal assembly adapted to be positioned on the tympanic membrane of a user, the medial ear canal assembly comprising a retention structure adapted to conform to the anatomy of the user's ear canal, wherein the retention structure includes a first end corresponding to a shape profile of the anterior sulcus and the anterior portion of the tympanic membrane annulus; wherein the first end comprises an end portion having a convex shape profile to facilitate the advancement of the first end into the anterior sulcus; and a drug delivery device mounted on the ear canal assembly. a medial ear canal assembly adapted to be positioned on the tympanic membrane of a user, the medial ear canal assembly comprising a retention structure adapted to conform to the anatomy of the user's ear canal, wherein the retention structure includes a first end corresponding to a shape profile of the anterior sulcus and the anterior portion of the tympanic membrane annulus; wherein the first end comprises an end portion having a convex shape profile to facilitate the advancement of the first end into the anterior sulcus; and a drug delivery device mounted on the ear canal assembly.
A system for separation of analytes in a solution, said system comprising: • a cartridge enclosing a sorbent for binding the analytes in the solution • a recipient socket for receiving the cartridge, and allowing a fluid to flow through the cartridge into the recipient socket, thereby eluting the analytes into the recipient socket; • a conduit in fluid communication with the recipient socket, said conduit establishing a fluid link to a valve or via a coupling conduit into the valve, said valve providing access to a holding-loop with or without sorbent, wherein said holding-loop is part of the system and is configured to provide low flow resistance at flow rates of between 200nL/min and 50μL/min enabling elution through the cartridge and into said holding-loop at pressures of between 1 bar and 50 bar; wherein the valve is switchable to a position following the elution from the cartridge and into said holding-loop for emptying said holding-loop through an outlet port at pressures of between 1 bar and 3000 bar at flow rates of between 50nL/min and 20μL/min; and • optionally a chromatographic column in fluid communication with the outlet port, said column provided with a sorbent having a chemical composition that is matched with the binding material of the cartridge such that at least some of the analytes eluted from the cartridge will bind to said chromatographic column. • a cartridge enclosing a sorbent for binding the analytes in the solution • a recipient socket for receiving the cartridge, and allowing a fluid to flow through the cartridge into the recipient socket, thereby eluting the analytes into the recipient socket; • a conduit in fluid communication with the recipient socket, said conduit establishing a fluid link to a valve or via a coupling conduit into the valve, said valve providing access to a holding-loop with or without sorbent, wherein said holding-loop is part of the system and is configured to provide low flow resistance at flow rates of between 200nL/min and 50μL/min enabling elution through the cartridge and into said holding-loop at pressures of between 1 bar and 50 bar; wherein the valve is switchable to a position following the elution from the cartridge and into said holding-loop for emptying said holding-loop through an outlet port at pressures of between 1 bar and 3000 bar at flow rates of between 50nL/min and 20μL/min; and • optionally a chromatographic column in fluid communication with the outlet port, said column provided with a sorbent having a chemical composition that is matched with the binding material of the cartridge such that at least some of the analytes eluted from the cartridge will bind to said chromatographic column.
A security system for use in a distributed network, comprising: a service provider selectively accessible via a network by a plurality of end users each having an access device for accessing the network, said access device having a configuration file downloaded during startup of the access device; and a control mechanism disposed at a location of the service provider configured to access and modify stored information of the configuration file on each access device of the end users to designate portions of the information to prevent access thereof by the end users. a service provider selectively accessible via a network by a plurality of end users each having an access device for accessing the network, said access device having a configuration file downloaded during startup of the access device; and a control mechanism disposed at a location of the service provider configured to access and modify stored information of the configuration file on each access device of the end users to designate portions of the information to prevent access thereof by the end users.
A shaft seal assembly for sealing an annular gap between a rotating shaft and a shaft bore of a housing and restraining a leak of powder from a sealed region having a vacuum, the shaft seal assembly comprising: a first seal structure disposed at a sealed region side; and a second seal structure disposed at an atmosphere side opposite the sealed region with respect to the first seal structure, a seal cover is fixed to the first stationary ring and the second stationary ring at an outer circumference side, the seal cover forming a sealed space between the first seal structure and the second seal structure, characterized in that the shaft seal assembly comprises a vacuum generating mechanism capable of providing a vacuum in the sealed space, wherein the first seal structure comprises a first stationary ring fixed to the housing and a first rotating ring fixed to the rotating shaft, the first seal structure being a non-contacting seal structure having a small gap between an end face of the first stationary ring at the atmosphere side and an end face of the first rotating ring at the sealed region side, the second seal structure comprises a second stationary ring fixed to the housing and a second rotating ring fixed to the rotating shaft, the second seal structure being a contacting seal structure in which an axial end face of the second stationary ring and an axial end face of the second rotating ring slide relative to each other. a first seal structure disposed at a sealed region side; and a second seal structure disposed at an atmosphere side opposite the sealed region with respect to the first seal structure,
Cross-country or touring ski binding for hingedly connecting a boot to a ski, - comprising a binding main body which has a standing surface for a sole of the boot and a ski contact surface for at least indirectly contacting the ski, - comprising a holding device which has a receptacle for pivotably arranging the boot about a pivot axis extending in the transverse direction of the binding main body and which has a holding element for holding the boot on the receptacle, the holding element being mounted so as to be movable on the binding main body between a closed position that holds the boot on the receptacle and an open position that releases the boot, - comprising an actuating element which has a rotary handle for transferring the holding element from the closed position into the open position, the rotary shaft of which rotary handle extends substantially perpendicularly to the standing surface of the binding main body, characterised in that - a locking element which can be transferred between a locking position and a release position is provided, the rotary handle being form-fittingly held in the locking position such that it cannot rotate with respect to the binding main body, the locking element being designed such that it cannot be released from the form-fitting connection by means of resilient deformation, and the rotary handle being released in the release position for a pivot movement about its rotary shaft. - comprising a binding main body which has a standing surface for a sole of the boot and a ski contact surface for at least indirectly contacting the ski, - comprising a holding device which has a receptacle for pivotably arranging the boot about a pivot axis extending in the transverse direction of the binding main body and which has a holding element for holding the boot on the receptacle, the holding element being mounted so as to be movable on the binding main body between a closed position that holds the boot on the receptacle and an open position that releases the boot, - comprising an actuating element which has a rotary handle for transferring the holding element from the closed position into the open position, the rotary shaft of which rotary handle extends substantially perpendicularly to the standing surface of the binding main body, characterised in that - a locking element which can be transferred between a locking position and a release position is provided, the rotary handle being form-fittingly held in the locking position such that it cannot rotate with respect to the binding main body, the locking element being designed such that it cannot be released from the form-fitting connection by means of resilient deformation, and the rotary handle being released in the release position for a pivot movement about its rotary shaft.
A product package comprising ajar and a lid that is removably securable to the jar, wherein the lid has an inner wall, the package further comprising a two-way humidity control device for controlling headspace relative humidity in the product package, the humidity control device comprising: a base layer; a permeable layer comprising a material permeable to water vapor and impermeable to aqueous solutions; and a humidity control agent arranged between the base layer and permeable layer; wherein the base layer of the humidity control device is the inner wall of the lid and the permeable layer is coupled to the inner surface of the lid by an adhesive. a base layer; a permeable layer comprising a material permeable to water vapor and impermeable to aqueous solutions; and a humidity control agent arranged between the base layer and permeable layer; wherein the base layer of the humidity control device is the inner wall of the lid and the permeable layer is coupled to the inner surface of the lid by an adhesive.
A method of operating a communication device operating in a communications network and configured to communicate with a network node operating in the communications network via a primary cell, PCell, and one or more secondary cells, SCells, the method comprising: receiving a configuration message from the network node to configure an SCell of the one or more SCells as a scheduling cell for cross carrier scheduling wherein when the configuration message configures the SCell as the scheduling cell the communication device is configured to: monitor the SCell for first scheduling information associated with communications via the PCell; only monitor the PCell for second scheduling information associated with second communications for the PCell and not monitor for any scheduling information associated with communications for any other SCells of the one or more SCells on the PCell; and only monitor for scheduling related to communications for the SCell configured for scheduling on said SCell. monitor the SCell for first scheduling information associated with communications via the PCell; only monitor the PCell for second scheduling information associated with second communications for the PCell and not monitor for any scheduling information associated with communications for any other SCells of the one or more SCells on the PCell; and only monitor for scheduling related to communications for the SCell configured for scheduling on said SCell.
An apparatus for a host vehicle, the apparatus arranged to; monitor or detect movement of an accelerator control of the host vehicle; perform a brake pre-arm operation when the accelerator control is moved at a rate, the magnitude of which exceeds a first prescribed rate in a direction to decrease an amount of power developed by a powertrain of the host vehicle, the brake-pre-arm operation being an operation in which a pressure of brake fluid of the host vehicle is increased thereby to reduce an amount of time taken to slow the host vehicle if the brake pressure is subsequently increased the apparatus characterised in that it is further arranged to: monitor one or more target objects in an environment external to the host vehicle by means of at least one sensor; trigger at least one action responsive to the detection of prescribed relative movement between the host vehicle and the one or more target objects; and over-ride triggering of the at least one action when the accelerator control is moved at a rate exceeding a second prescribed rate in a direction to decrease an amount of power developed by a powertrain. monitor one or more target objects in an environment external to the host vehicle by means of at least one sensor; trigger at least one action responsive to the detection of prescribed relative movement between the host vehicle and the one or more target objects; and over-ride triggering of the at least one action when the accelerator control is moved at a rate exceeding a second prescribed rate in a direction to decrease an amount of power developed by a powertrain.
A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding parts are arranged, the molding compact comprising a laminated structure comprising: a first member having needle-shaped recessed parts formed on a front surface thereof, the needle-shaped recessed parts being an inverse of the needle-shaped protruding parts; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body, characterized in that an air permeability of the second member and the third member is 3 seconds/100 cm 3 or more and 100 seconds/100 cm 3 or less, the air permeability being measured according to the Gurley tester method described in JIS P8 117 - 2009 edition. a first member having needle-shaped recessed parts formed on a front surface thereof, the needle-shaped recessed parts being an inverse of the needle-shaped protruding parts; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body, characterized in that an air permeability of the second member and the third member is 3 seconds/100 cm 3 or more and 100 seconds/100 cm 3 or less, the air permeability being measured according to the Gurley tester method described in JIS P8 117 - 2009 edition.
A method of filling a fluid drug formulation within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a stent, the method comprising the steps of: placing a stent formed from a hollow wire having a plurality of side openings within a chamber that houses a fluid drug formulation and a wicking means that is in contact with the fluid drug formulation, wherein the chamber is at or near the vapor-liquid equilibrium of a solvent of the fluid drug formulation; placing a portion of the stent into contact with the wicking means such that at least one of the plurality of side openings is in contact with the wicking means; and maintaining contact between the wicking means and the selected portion of the stent until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action through the at least one of the plurality of side openings in contact with the wicking means. placing a stent formed from a hollow wire having a plurality of side openings within a chamber that houses a fluid drug formulation and a wicking means that is in contact with the fluid drug formulation, wherein the chamber is at or near the vapor-liquid equilibrium of a solvent of the fluid drug formulation; placing a portion of the stent into contact with the wicking means such that at least one of the plurality of side openings is in contact with the wicking means; and maintaining contact between the wicking means and the selected portion of the stent until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action through the at least one of the plurality of side openings in contact with the wicking means.
A fuel gas manifold assembly configured to be used in an internal combustion piston engine, the fuel gas manifold assembly comprising a gas tight fuel gas manifold defining a longitudinal passage for fuel gas, a fuel gas inlet and a number of fuel gas outlets along the longitudinal passage, the fuel gas manifold assembly further comprising an outer enclosure surrounding the fuel gas manifold so as to provide a gas tight cover for the fuel gas manifold, and wherein an intermediate gas space is arranged between the inner fuel gas manifold and the outer enclosure, characterized in that the outer enclosure is provided with a planar face wall extending from one end of the enclosure to the second end of the enclosure and that the planar face wall is provided with a number of main openings along its length, arranged to communicate with the fuel gas outlets of the manifold in the enclosure and that there is arranged at least one auxiliary opening next to each one of the main openings in the planar wall communicating with the intermediate gas space.
An implantable prosthetic valve comprising: an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration; a leaflet structure positioned within the frame and secured thereto; and an outer skirt (18; 300; 400; 500) positioned around an outer surface of the frame, wherein the outer skirt (18; 300; 400; 500) comprises pericardial tissue having a fibrous parietal layer defining a first surface of the outer skirt (18; 300; 400; 500) and a serous parietal layer defining a second surface of the outer skirt (18; 300; 400; 500), and wherein the outer skirt (18; 300; 400; 500) is positioned such that the first surface is facing away from the frame and the second surface is facing towards the frame. an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration; a leaflet structure positioned within the frame and secured thereto; and an outer skirt (18; 300; 400; 500) positioned around an outer surface of the frame, wherein the outer skirt (18; 300; 400; 500) comprises pericardial tissue having a fibrous parietal layer defining a first surface of the outer skirt (18; 300; 400; 500) and a serous parietal layer defining a second surface of the outer skirt (18; 300; 400; 500), and wherein the outer skirt (18; 300; 400; 500) is positioned such that the first surface is facing away from the frame and the second surface is facing towards the frame.
Support box for a vehicle signaling module automobile comprising a light source and an associated electronic circuit, said housing comprising a lower shell and a 5 upper shell delimiting between them an open compartment at the front to allow the introduction of the module, said lower shell and said upper shell carrying, at the rear, guiding members, connection and locking members cooperating mutually to ensure the assembly of the two hulls (1, 2); characterized in that 10 said guide members comprise, on the lower shell, a groove peripheral intended to receive the end edge of the shell upper by following its contours; said peripheral groove has, at one of its longitudinal ends, a substantially vertical portion and, at its other end, a portion 15 truncated offering freedom of movement to the upper shell when of the assembly. said housing comprising a lower shell and a 5 upper shell delimiting between them an open compartment at the front to allow the introduction of the module, said lower shell and said upper shell carrying, at the rear, guiding members, connection and locking members cooperating mutually to ensure the assembly of the two hulls (1, 2); characterized in that 10 said guide members comprise, on the lower shell, a groove peripheral intended to receive the end edge of the shell upper by following its contours; said peripheral groove has, at one of its longitudinal ends, a substantially vertical portion and, at its other end, a portion 15 truncated offering freedom of movement to the upper shell when of the assembly.
Flow-directing element for a heating apparatus, in particular a heating apparatus with an evaporator burner having a body which comprises a laterally arranged inflow region on an underside of the flow-directing element, having a centrally arranged outflow region, which comprises a through-passage from an underside of the flow-directing element to an upper side of the flow-directing element, the upper side being located opposite the underside, and having at least one guide element which is arranged such that it allows flow to be guided from the inflow region to the outflow region, wherein the inflow region is designed as a bulge.
A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of Angiopoietin-like 3 (ANGPTL3), comprising a sense strand and an antisense strand, wherein the sense strand and antisense strand form a region of complementarity of at least 17 nucleotides in length, wherein said dsRNA comprises at least one modified nucleotide, wherein at least one of the modified nucleotides is selected from the group consisting of a 2'-O-methyl modified nucleotide, a 2'-fluoro modified nucleotide, a nucleotide comprising a 5'-phosphorothioate group, and a 2'-amino modified nucleotide, and wherein said dsRNA comprises a ligand comprising an N-acetylgalactosamine (GalNAc) derivative, wherein the antisense strand comprises at least 17 contiguous nucleotides which differ by no more than three nucleotides from the nucleotide sequence of: (a) 5'-AAAGACUGAUCAAAUAUGUUGAG-3' (nucleotides 274-296 of SEQ ID NO: 1); (b) 5'-AAGACUGAUCAAAUAUGUUGAGU-3' (nucleotides 273-295 of SEQ ID NO: 1); or (c) 5'-AGACUGAUCAAAUAUGUUG-3' (nucleotides 276-294 of SEQ ID NO: 1). wherein the sense strand and antisense strand form a region of complementarity of at least 17 nucleotides in length, wherein said dsRNA comprises at least one modified nucleotide, wherein at least one of the modified nucleotides is selected from the group consisting of a 2'-O-methyl modified nucleotide, a 2'-fluoro modified nucleotide, a nucleotide comprising a 5'-phosphorothioate group, and a 2'-amino modified nucleotide, and wherein said dsRNA comprises a ligand comprising an N-acetylgalactosamine (GalNAc) derivative, wherein the antisense strand comprises at least 17 contiguous nucleotides which differ by no more than three nucleotides from the nucleotide sequence of: (a) 5'-AAAGACUGAUCAAAUAUGUUGAG-3' (nucleotides 274-296 of SEQ ID NO: 1); (b) 5'-AAGACUGAUCAAAUAUGUUGAGU-3' (nucleotides 273-295 of SEQ ID NO: 1); or (c) 5'-AGACUGAUCAAAUAUGUUG-3' (nucleotides 276-294 of SEQ ID NO: 1). (a) 5'-AAAGACUGAUCAAAUAUGUUGAG-3' (nucleotides 274-296 of SEQ ID NO: 1); (b) 5'-AAGACUGAUCAAAUAUGUUGAGU-3' (nucleotides 273-295 of SEQ ID NO: 1); or (c) 5'-AGACUGAUCAAAUAUGUUG-3' (nucleotides 276-294 of SEQ ID NO: 1).
A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein R, is selected from the group consisting of F, Cl, Br, CF 3, CCl 3, CN, SO 2 NHR, COR, CONHR and R; wherein R 2 = R; wherein X = CH or CR; wherein Y is O, NH or NR; wherein n = 2-4; and wherein R is H, alkyl, aryl, alkoxy or aryloxy.