A compound of Formula wherein: Y is a carbonyl group (C=O) or is absent; X is -(CR 8 R 9) m -, optionally substituted heteroaryl or optionally substituted heterocyclyl, Z is C=O, -O-, -NR 7 -, -CONH-, -NHCO- or may be absent; R 1 and R 2 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted thioalkyl, optionally substituted arylalkyl or optionally substituted aryl; R 3 and R 4 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl, wherein the substituents are alkyl, halogen or OH; R 5 is hydrogen, halogen, optionally substituted alkyl or OR 6; R 6 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R 7 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R 8 and R 9 are independently hydrogen, halogen, optionally substituted alkyl or optionally substituted cycloalkyl; or R 8 and R 9 can be taken together to form a carbocyclic ring; R 10 and R 11 are independently hydrogen, halogen or optionally substituted alkyl; or R 8 and R 9 can be taken together to form a carbocyclic ring; R 12, R 13, R 14, R 15 and R 16 are independently hydrogen, halogen or optionally substituted alkyl or OR 17; R 17 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q and t are independently 0, 1, 2, 3, or 4; r is 0 or 1; and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. Y is a carbonyl group (C=O) or is absent; X is -(CR 8 R 9) m -, optionally substituted heteroaryl or optionally substituted heterocyclyl, Z is C=O, -O-, -NR 7 -, -CONH-, -NHCO- or may be absent; R 1 and R 2 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted thioalkyl, optionally substituted arylalkyl or optionally substituted aryl; R 3 and R 4 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl, wherein the substituents are alkyl, halogen or OH; R 5 is hydrogen, halogen, optionally substituted alkyl or OR 6; R 6 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R 7 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R 8 and R 9 are independently hydrogen, halogen, optionally substituted alkyl or optionally substituted cycloalkyl; or R 8 and R 9 can be taken together to form a carbocyclic ring; R 10 and R 11 are independently hydrogen, halogen or optionally substituted alkyl; or R 8 and R 9 can be taken together to form a carbocyclic ring; R 12, R 13, R 14, R 15 and R 16 are independently hydrogen, halogen or optionally substituted alkyl or OR 17; R 17 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q and t are independently 0, 1, 2, 3, or 4; r is 0 or 1;