A Compound of general formula I wherein Q is a group of formula Y is selected from Y2 divalent groups of formula wherein A2 is absent and A1 is independently selected from methylene, ethylene, n- propylene, isopropylene, butylene, pentylene, hexylene, octylene; B is absent or is selected from (C 3 -C 8)heterocycloalkylene which is piperidinylene, arylene which is phenylene, and heteroarylene which is pyridine-diyl, or pyrazole-diyl; B being optionally substituted by one or more groups selected from -OH, halogen which is fluorine, chlorine and bromine, (C 1 -C 6)alkyl which is methyl, (C 1 -C 6)alkoxy which is methoxy, ethoxy, isopropoxy, (C 1 -C 6)haloalkyl which is trifluoromethyl, and (C 1 -C 6)haloalkoxy which is trifluoromethoxy; C is absent or is selected from -O-, -C -, or is one of the following groups C1, C2, C4, C7, C8, C9, C10, C12, C13, C14, C15, C16, C17,C18, C19, C20, C21 C22 C23 wherein R 7 is in each occurrence independently H or selected from (C 1 -C 8)alkyl which is methyl, ethyl and aryl(C 1 -C 6)alkyl which is benzyl; D is absent or is selected from arylene which is para-phenylene or meta-phenylene, (C 3 -Cs)cycloalkylene which is cyclohexanediyl, (C 3 -C 8)heterocycloalkylene which is piperidindiyl, pyrrolidindiyl or azetidindiyl; n is at each occurrence independently 0 or an integer from 1 to 3; m is at each occurrence independently an integer from 1 to 3; E is absent or is selected from -O-, -NR 7 - which is -NH-, -NR 7 C - which is -NH-C -, -C NR 7 - which is -C -NH-, -C (CH 2) n -O- which is -C -CH 2 -O- and -NR 7 C (CH 2) n O- which is -NH-C -CH 2 -O-; G is arylene which is meta-phenylene; R 1 is selected from, thiophenyl, cyclohexyl, cyclopentyl and phenyl optionally substituted by one or more group selected independently from fluorine, methyl, ethyl and methoxy; s is 0 or an integer from 1 to 3; R 2 is a nitrogen containing group which may be selected from: - a group (a) which is -NR 3 R 4 wherein R 3 and R 4 are methyl; and - a group (b) of formula J1, J2, J3, J4 or J5 R 5 is methyl or benzyl; and pharmaceutically acceptable salts or solvates thereof. Q is a group of formula Y is selected from Y2 divalent groups of formula wherein A2 is absent and A1 is independently selected from methylene, ethylene, n- propylene, isopropylene, butylene, pentylene, hexylene, octylene; B is absent or is selected from (C 3 -C 8)heterocycloalkylene which is piperidinylene, arylene which is phenylene, and heteroarylene which is pyridine-diyl, or pyrazole-diyl; B being optionally substituted by one or more groups selected from -OH, halogen which is fluorine, chlorine and bromine, (C 1 -C 6)alkyl which is methyl, (C 1 -C 6)alkoxy which is methoxy, ethoxy, isopropoxy, (C 1 -C 6)haloalkyl which is trifluoromethyl, and (C 1 -C 6)haloalkoxy which is trifluoromethoxy; C is absent or is selected from -O-, -C -, or is one of the following groups C1, C2, C4, C7, C8, C9, C10, C12, C13, C14, C15, C16, C17,C18, C19, C20, C21 C22 C23 wherein R 7 is in each occurrence independently H or selected from (C 1 -C 8)alkyl which is methyl, ethyl and aryl(C 1 -C 6)alkyl which is benzyl; D is absent or is selected from arylene which is para-phenylene or meta-phenylene, (C 3 -Cs)cycloalkylene which is cyclohexanediyl, (C 3 -C 8)heterocycloalkylene which is piperidindiyl, pyrrolidindiyl or azetidindiyl; n is at each occurrence independently 0 or an integer from 1 to 3; m is at each occurrence independently an integer from 1 to 3; E is absent or is selected from -O-, -NR 7 - which is -NH-, -NR 7 C - which is -NH-C -, -C NR 7 - which is -C -NH-, -C (CH 2) n -O- which is -C -CH 2 -O- and -NR 7 C (CH 2) n O- which is -NH-C -CH 2 -O-; G is arylene which is meta-phenylene; R 1 is selected from, thiophenyl, cyclohexyl, cyclopentyl and phenyl optionally substituted by one or more group selected independently from fluorine, methyl, ethyl and methoxy; s is 0 or an integer from 1 to 3; R 2 is a nitrogen containing group which may be selected from: - a group (a) which is -NR 3 R 4 wherein R 3 and R 4 are methyl; and - a group (b) of formula J1, J2, J3, J4 or J5 - a group (a) which is -NR 3 R 4 wherein R 3 and R 4 are methyl; and - a group (b) of formula J1, J2, J3, J4 or J5 R 5 is methyl or benzyl; and pharmaceutically acceptable salts or solvates thereof.