A prosthetic heart valve system for treating a defective native aortic valve, the native aortic valve (210, 304) having three leaflets (60, 62, 64), three commissures (50, 52, 54), and an annulus, the prosthetic heart valve system comprising: a support stent (10, 310) radially compressible into a compressed state and self-expandable into an uncompressed state, the support stent dimensioned for deployment within an aorta of a patient adjacent to the three leaflets (60, 62, 64) on an outflow side of the native aortic valve (210, 304), circumscribing the native aortic valve, the support stent (10, 310) comprising an annular body having one or more peaks and one or more valleys along a circumference thereof, and an interior with an inner diameter when in the uncompressed state, the support stent further comprising at least one retaining arm (21, 23, 25, 321, 322, 323) disposed at a respective peak, the at least one retaining arm (21, 23, 25, 321, 322, 323) comprising an aperture (26, 27, 28, 326, 327, 328); and an expandable prosthetic heart valve (250, 340) dimensioned for deployment within the annulus of the native aortic valve (210, 304), the prosthetic heart valve (250, 340) comprising a stent portion and a valve structure supported within the stent portion, the stent portion having an outer diameter; wherein the outer diameter of the stent portion is sized for deployment within the inner diameter of the support stent (10, 310) in its uncompressed state, and wherein the prosthetic heart valve (250, 340) and the support stent are shaped for pinching and frictionally securing the native leaflets (60, 62, 64) of the native aortic valve (210, 304) between the support stent (10, 310) and the prosthetic heart valve (250, 340) when the support stent (10, 310) is deployed on the outflow side of the native aortic valve (210, 304) and the prosthetic heart valve (250, 340) is deployed in the annulus of the native aortic valve (210, 304) and fully expanded. a support stent (10, 310) radially compressible into a compressed state and self-expandable into an uncompressed state, the support stent dimensioned for deployment within an aorta of a patient adjacent to the three leaflets (60, 62, 64) on an outflow side of the native aortic valve (210, 304), circumscribing the native aortic valve, the support stent (10, 310) comprising an annular body having one or more peaks and one or more valleys along a circumference thereof, and an interior with an inner diameter when in the uncompressed state, the support stent further comprising at least one retaining arm (21, 23, 25, 321, 322, 323) disposed at a respective peak, the at least one retaining arm (21, 23, 25, 321, 322, 323) comprising an aperture (26, 27, 28, 326, 327, 328); and an expandable prosthetic heart valve (250, 340) dimensioned for deployment within the annulus of the native aortic valve (210, 304), the prosthetic heart valve (250, 340) comprising a stent portion and a valve structure supported within the stent portion, the stent portion having an outer diameter; wherein the outer diameter of the stent portion is sized for deployment within the inner diameter of the support stent (10, 310) in its uncompressed state, and wherein the prosthetic heart valve (250, 340) and the support stent are shaped for pinching and frictionally securing the native leaflets (60, 62, 64) of the native aortic valve (210, 304) between the support stent (10, 310) and the prosthetic heart valve (250, 340) when the support stent (10, 310) is deployed on the outflow side of the native aortic valve (210, 304) and the prosthetic heart valve (250, 340) is deployed in the annulus of the native aortic valve (210, 304) and fully expanded.