A system configured to enable determination of one or more sleep phenotyping parameters of a subject, the system comprising: a sleep sensor configured to generate one or more output signals that convey information related to one or more physiological functions that indicate a sleep stage of a subject; a stimulus generator configured to selectively provide a stimulus to the subject, wherein a response of the subject to the stimulus enables information related to the one or more sleep phenotyping parameters to be determined; a processor that receives the one or more output signals generated by the sleep sensor and being in operative communication with the stimulus generator, the processor being configured (i) to determine, based on the one or more output signals received from the sleep sensor, whether a trigger condition related to the current sleep stage of the subject is satisfied, and (ii) to control the stimulus generator to provide the stimulus to the subject if the trigger condition is satisfied, wherein the one or more sleep phenotyping parameters comprise arousal threshold, wherein the processor is further configured to determine a current sleep stage of the subject based on the one or more output signals generated by the sleep sensor, and wherein the trigger condition comprises that the subject is asleep such that provision of the stimulus to the subject is triggered if the current sleep stage determined by the processor is that the subject is asleep, characterized in that the stimulus generator is further configured to provide the stimulus in an incremental manner to the subject until arousal takes place, wherein the processor is further configured to determine the magnitude of the stimulus required to wake the subject. a sleep sensor configured to generate one or more output signals that convey information related to one or more physiological functions that indicate a sleep stage of a subject; a stimulus generator configured to selectively provide a stimulus to the subject, wherein a response of the subject to the stimulus enables information related to the one or more sleep phenotyping parameters to be determined; a processor that receives the one or more output signals generated by the sleep sensor and being in operative communication with the stimulus generator, the processor being configured (i) to determine, based on the one or more output signals received from the sleep sensor, whether a trigger condition related to the current sleep stage of the subject is satisfied, and (ii) to control the stimulus generator to provide the stimulus to the subject if the trigger condition is satisfied, wherein the one or more sleep phenotyping parameters comprise arousal threshold, wherein the processor is further configured to determine a current sleep stage of the subject based on the one or more output signals generated by the sleep sensor, and wherein the trigger condition comprises that the subject is asleep such that provision of the stimulus to the subject is triggered if the current sleep stage determined by the processor is that the subject is asleep, characterized in that the stimulus generator is further configured to provide the stimulus in an incremental manner to the subject until arousal takes place, wherein the processor is further configured to determine the magnitude of the stimulus required to wake the subject.