mhurhangee/ep-ind-claims huggingface dataset:
A drug delivery platform for cell therapy, comprising: a. an engineered protein on a target cell for transplant, wherein the engineered protein comprises a first component and a second component, the first component and the second component are connected by a peptide linker, the first component is a non-membrane protein, the second component is a membrane anchored peptide or protein; b. at least one small ligand conjugated to a linker, wherein the at least one small ligand has intrinsic high affinity to at least one component of the engineered protein; and c. at least one payload of drug conjugated to the linker, wherein the payload of drug is associated with the target cell when the small ligand binds to at least one component of the engineered protein. a. an engineered protein on a target cell for transplant, wherein the engineered protein comprises a first component and a second component, the first component and the second component are connected by a peptide linker, the first component is a non-membrane protein, the second component is a membrane anchored peptide or protein; b. at least one small ligand conjugated to a linker, wherein the at least one small ligand has intrinsic high affinity to at least one component of the engineered protein; and c. at least one payload of drug conjugated to the linker, wherein the payload of drug is associated with the target cell when the small ligand binds to at least one component of the engineered protein.
A method executable by a media player device (120A, 120B, 120C) to avoid a stall during playback of an adaptive media stream (105A, 105B, 105C) delivered over a network, the method comprising: placing requests from the media player device (120A, 120B, 120C) for segments of the media stream (105A, 105B, 105C) to be delivered to the media device via the network; receiving the requested segments of the media stream (105A, 105B, 105C)in a receive buffer of the media player device for playback of the media stream by the media player device (120A, 120B, 120C); monitoring a utilization of the receive buffer to determine a rate of change in the utilization of the receive buffer by performing a linear regression of the buffer utilization; and adjusting future requests for segments of the media stream based upon the determined rate of change in the utilization of the receive buffer, wherein the adjusting comprises placing future requests for future segments having a lower quality than the received segments when the rate of change in the utilization of the receive buffer shows a declining buffer utilization and placing future requests for future segments having a higher quality than the received segments when the rate of change in the utilization of the receive buffer shows an increasing buffer utilization, and wherein the adjusting comprises comparing the determined rate of change in the buffer utilization to each of a plurality of threshold levels and changing the quality level of the future segments when the rate of change passes any of the threshold levels. placing requests from the media player device (120A, 120B, 120C) for segments of the media stream (105A, 105B, 105C) to be delivered to the media device via the network; receiving the requested segments of the media stream (105A, 105B, 105C)in a receive buffer of the media player device for playback of the media stream by the media player device (120A, 120B, 120C); monitoring a utilization of the receive buffer to determine a rate of change in the utilization of the receive buffer by performing a linear regression of the buffer utilization; and adjusting future requests for segments of the media stream based upon the determined rate of change in the utilization of the receive buffer, wherein the adjusting comprises placing future requests for future segments having a lower quality than the received segments when the rate of change in the utilization of the receive buffer shows a declining buffer utilization and placing future requests for future segments having a higher quality than the received segments when the rate of change in the utilization of the receive buffer shows an increasing buffer utilization, and wherein the adjusting comprises comparing the determined rate of change in the buffer utilization to each of a plurality of threshold levels and changing the quality level of the future segments when the rate of change passes any of the threshold levels.
Device for disposal of neutron flux sensors and/or thermocouples comprising a shielding body with a longitudinal cavity inside, the shielding body being provided with an input opening in its lower part to allow insertion of said sensors and/or thermocouples, wherein a cutting mechanism is arranged in an upper part of the cavity, said cutting mechanism comprising a cutting body (3.1) and a cutting head (3.4); a receptacle is arranged within the cavity below said cutting mechanism to store said sensors and/or thermocouples being disposed, said cutting mechanism is arranged above the receptacle to allow a direct transfer of the cut-off parts of the sensor and/or thermocouples into the receptacle by gravity; wherein a channel is provided above the input opening; the device being characterized in that said channel has a vertical part and a bent part, said vertical part of the channel being formed in parallel to the vertical axis of the shielding body and said bent part of the channel being provided to supply the sensors and/or thermocouples to the cutting mechanism, and wherein a feeding mechanism is provided at the input opening to feed the sensors and/or thermocouples from the input opening through the channel to the cutting mechanism.
A structure for cooling turbine blades, comprising: a turbine blade connected to a turbine blade root; a turbine disk including a slot for receiving the turbine blade root, a cooling passage inside the turbine disk through which cooling air flows to the turbine blade root, and a branch passage formed inside the turbine disk and communicating at one end with the cooling passage, wherein the one end is formed inside the turbine disk; and a retainer fixed to the turbine disk on each of opposite sides of the turbine blade to prevent separation of the turbine blade from the turbine disk, the fixed retainer having a chamber communicating with the other end of the branch passage so that the cooling air of the cooling passage is introduced into the chamber through the branch passage. a turbine blade connected to a turbine blade root; a turbine disk including a slot for receiving the turbine blade root, a cooling passage inside the turbine disk through which cooling air flows to the turbine blade root, and a branch passage formed inside the turbine disk and communicating at one end with the cooling passage, wherein the one end is formed inside the turbine disk; and a retainer fixed to the turbine disk on each of opposite sides of the turbine blade to prevent separation of the turbine blade from the turbine disk, the fixed retainer having a chamber communicating with the other end of the branch passage so that the cooling air of the cooling passage is introduced into the chamber through the branch passage.
An awning with a housing receiving a storage device for an awning cover, a front rail associated with it via hinge arms holding the end of the awning cover facing away from the storage device, and several brackets allocated to the housing, attachable to an assembly base with good bearing and with mutual lateral distance, characterized in that the housing can be received on the brackets by means of a supporting tube extending across all brackets and attached to it, and that the housing comprises a channel open to the rear and supports arranged in it and allocated to the supporting tube, by means of which the housing can be put onto the supporting tube with a shifting direction extending transverse to the longitudinal direction of the housing, with the supporting tube together with the elements of the brackets affixed to it immersing into the rearward channel of the housing.
A microcapsule system consisting of - an outer capsule which encloses by means of an outer envelope a volume containing at least one active substance, and - at least one inner capsule, which is entirely surrounded by the outer capsule, said inner capsule having an envelope enclosing a volume, characterised in that - the outer envelope of the outer capsule has pores, - the volume in the inner capsule is a regulating substance containing a mixture of water and freezing-point depressant the volume of which increases as the ambient temperature progressively decreases, thus activating a release of at least a portion of the volume of the active substance, which is an antifreeze agent, from the outer envelope of the outer capsule. - an outer capsule which encloses by means of an outer envelope a volume containing at least one active substance, and - at least one inner capsule, which is entirely surrounded by the outer capsule, said inner capsule having an envelope enclosing a volume, characterised in that - the outer envelope of the outer capsule has pores, - the volume in the inner capsule is a regulating substance containing a mixture of water and freezing-point depressant the volume of which increases as the ambient temperature progressively decreases, thus activating a release of at least a portion of the volume of the active substance, which is an antifreeze agent, from the outer envelope of the outer capsule.
A perspiration control glove, characterized in that the glove comprises: a highly wicking knitted liner comprising a knitted yarn having fibers of an irregular cross section that form channels for wicking perspiration; an elastomeric shell comprising a polymeric material, the elastomeric shell adhered to the highly wicking knitted liner; and an absorbent material element (114, 118) to absorb perspiration coupled to the channels, and disposed between the highly wicking knitted liner and the elastomeric shell. a highly wicking knitted liner comprising a knitted yarn having fibers of an irregular cross section that form channels for wicking perspiration; an elastomeric shell comprising a polymeric material, the elastomeric shell adhered to the highly wicking knitted liner; and an absorbent material element (114, 118) to absorb perspiration coupled to the channels, and disposed between the highly wicking knitted liner and the elastomeric shell.
A drug delivery device for administering a low dose of a medicament, comprising: a rigid wall having a channel extending between a first side and second side; a first flexible connected to said first side of said rigid wall; a drug reservoir containing a medicament is formed in said first flexible portion; a second flexible connected to said second side of said rigid wall, said second flexible portion having a substantially bell shape forming a cavity therein; and a connected to said channel and said drug reservoir and extending into said cavity of said second flexible portion, such that when a first pressure is applied to said second flexible portion contacting a patient's skin, and the first pressure is released the second flexible portion returns to the bell shape to create a vacuum in said cavity for sucking the skin into said cavity such that the skin is pierced by the needle, and that when a second pressure is applied to said first flexible portion said medicament is dispensed after contacting said second flexible portion with the patient's skin and releasing the first pressure on said second flexible portion. a rigid wall having a channel extending between a first side and second side; a first flexible connected to said first side of said rigid wall; a drug reservoir containing a medicament is formed in said first flexible portion; a second flexible connected to said second side of said rigid wall, said second flexible portion having a substantially bell shape forming a cavity therein; and a connected to said channel and said drug reservoir and extending into said cavity of said second flexible portion, such that when a first pressure is applied to said second flexible portion contacting a patient's skin, and the first pressure is released the second flexible portion returns to the bell shape to create a vacuum in said cavity for sucking the skin into said cavity such that the skin is pierced by the needle, and that when a second pressure is applied to said first flexible portion said medicament is dispensed after contacting said second flexible portion with the patient's skin and releasing the first pressure on said second flexible portion.
A method comprising: communicating user account information to a commercial entity via a first communication component of an electronic device; receiving, from the commercial entity via the first communication component and responsive to communicating the user account information, a list comprising at least one commerce credential associated with the user account information under control of the commercial entity, the at least one commerce credential having passed a commercial entity fraud check performed by the commercial entity and a financial entity fraud check commissioned by the commercial entity based on results of the commercial entity fraud check; and transmitting a request to the commercial entity via the first communication component for initiating a credential provisioning process for provisioning, on the electronic device, of a credential corresponding to at least one of the at least one commerce credential associated with the user account information under the control of the commercial entity. communicating user account information to a commercial entity via a first communication component of an electronic device; receiving, from the commercial entity via the first communication component and responsive to communicating the user account information, a list comprising at least one commerce credential associated with the user account information under control of the commercial entity, the at least one commerce credential having passed a commercial entity fraud check performed by the commercial entity and a financial entity fraud check commissioned by the commercial entity based on results of the commercial entity fraud check; and transmitting a request to the commercial entity via the first communication component for initiating a credential provisioning process for provisioning, on the electronic device, of a credential corresponding to at least one of the at least one commerce credential associated with the user account information under the control of the commercial entity.
An aqueous coating composition, comprising a dispersion comprising (a) at least one latex polymer binder derived from at least one first monomer selected from the group consisting of acrylic acid, acrylic acid esters, methacrylic acid, methacrylic acid esters, styrene, vinyl toluene, vinyl acetate, vinyl esters of higher carboxylic acids than acetic acid, vinyl versatate, acrylonitrile, acrylamide, butadiene, ethylene, vinyl-chloride and mixtures thereof; (b) a biocide effective amount of at least one biocide comprising at least one biosurfactant selected from the group consisting of rhamnolipids and sophorolipids; and (c) water. (a) at least one latex polymer binder derived from at least one first monomer selected from the group consisting of acrylic acid, acrylic acid esters, methacrylic acid, methacrylic acid esters, styrene, vinyl toluene, vinyl acetate, vinyl esters of higher carboxylic acids than acetic acid, vinyl versatate, acrylonitrile, acrylamide, butadiene, ethylene, vinyl-chloride and mixtures thereof; (b) a biocide effective amount of at least one biocide comprising at least one biosurfactant selected from the group consisting of rhamnolipids and sophorolipids; and (c) water.
A ventilator unit having at least one ventilator, which is accommodated in a housing, in which a first diffuser apparatus is located, which diffuser apparatus is assigned to the ventilator and has diffuser blades, which are arranged in a distributed manner over the circumference, and to which diffuser apparatus a further diffuser apparatus is assigned, which lies behind the first diffuser apparatus in the flow path of the intake air, has further diffuser blades and is part of a protective grating, the blade height ratio H = h N1max /h N2max lying between 0.2 and 2.5, preferably between 0.4 and 2, h N1max being the maximum height of the diffuser blades in the housing and h N2max being the maximum height of the further diffuser blades, characterized in that the further diffuser blades are arranged, at least over a part of their length, on at least one rod-shaped support, which connects rings of the protective grating to one another, which rings lie coaxially to one another.
A method for switching a service path, applied to a network device, comprising: receiving reference information sent by a terminal device; and switching a specific service of the terminal device from a first connection path to a second connection path according to the reference information, the step of receiving the reference information sent by the terminal device comprises: receiving the reference information sent by the terminal device jointly through the first connection path and the second connection path, wherein the reference information is carried in a control message or user data transmitted through a protocol stack interface between the network device and the terminal device, wherein the reference information comprises at least one or more of followings: attribute information of the second connection path, description information of the specific service, preference description information and request information of the terminal device, wherein the request information of the terminal device is configured to characterize that the terminal device desires to switch the specific service to the second connection path. receiving reference information sent by a terminal device; and switching a specific service of the terminal device from a first connection path to a second connection path according to the reference information, the step of receiving the reference information sent by the terminal device comprises: receiving the reference information sent by the terminal device jointly through the first connection path and the second connection path, wherein the reference information is carried in a control message or user data transmitted through a protocol stack interface between the network device and the terminal device, wherein the reference information comprises at least one or more of followings: attribute information of the second connection path, description information of the specific service, preference description information and request information of the terminal device, wherein the request information of the terminal device is configured to characterize that the terminal device desires to switch the specific service to the second connection path. receiving the reference information sent by the terminal device jointly through the first connection path and the second connection path, wherein the reference information is carried in a control message or user data transmitted through a protocol stack interface between the network device and the terminal device, wherein the reference information comprises at least one or more of followings: attribute information of the second connection path, description information of the specific service, preference description information and request information of the terminal device, wherein the request information of the terminal device is configured to characterize that the terminal device desires to switch the specific service to the second connection path.
A liquid dispenser, comprising: a tank having an upper opening defined by an upper end of a wall; a pump installed in the water tank; a pipe through which liquid discharged from the pump is transferred; a plate provided above the wall of the tank over which liquid supplied from the pipe flows; and, a liquid guide provided below the plate, and provided on and supported by the wall of the tank and covering, together with the plate, the upper opening of the tank, wherein an outer wall of the liquid guide at least partially protrudes upward and outward from the upper end of the wall of the tank and is supported by the wall of the tank, characterized in that the liquid guide includes an inner wall spaced inward from the outer wall, and a drain passage is formed between the outer wall and the inner wall. a tank having an upper opening defined by an upper end of a wall; a pump installed in the water tank; a pipe through which liquid discharged from the pump is transferred; a plate provided above the wall of the tank over which liquid supplied from the pipe flows; and, a liquid guide provided below the plate, and provided on and supported by the wall of the tank and covering, together with the plate, the upper opening of the tank, wherein an outer wall of the liquid guide at least partially protrudes upward and outward from the upper end of the wall of the tank and is supported by the wall of the tank, characterized in that the liquid guide includes an inner wall spaced inward from the outer wall, and a drain passage is formed between the outer wall and the inner wall.
A modified adeno-associated virus vector packaging a recombinant AAV (rAAV)-based genome, for use in a method for treating a motor neuron degenerative disorder, the method comprising: administering to a subject suffering from said motor neuron degenerative disorder a modified adeno-associated virus vector packaging a recombinant AAV (rAAV)-based genome, wherein the rAAV-based genome comprises a ciliary neurotrophic factor receptor alpha (CNTFRα) cDNA insert, and wherein the method up-regulates CNTFRα RNA expression in skeletal muscle.
A method of detecting a force-producing input from a user and providing a user-customizable haptic output, comprising: receiving the input at an input arrangement (22, 28) of a user interface (20, 30), the input arrangement having at least one piezoelectric sensor; generating, at the at least one piezoelectric sensor, an electric signal in response to the input; processing the electric signal to determine a presence of the input; recording a force and a timing of the input; receiving a user selection of a haptic output to be generated in response to future instances of receiving an input with the same force and timing as the recorded force and timing; and generating, at an output arrangement (24, 28) of the user interface, the user selected haptic output in response to processing a subsequent electric signal generated in response to receiving an input with the same force and timing as the recorded force and timing. receiving the input at an input arrangement (22, 28) of a user interface (20, 30), the input arrangement having at least one piezoelectric sensor; generating, at the at least one piezoelectric sensor, an electric signal in response to the input; processing the electric signal to determine a presence of the input; recording a force and a timing of the input; receiving a user selection of a haptic output to be generated in response to future instances of receiving an input with the same force and timing as the recorded force and timing; and generating, at an output arrangement (24, 28) of the user interface, the user selected haptic output in response to processing a subsequent electric signal generated in response to receiving an input with the same force and timing as the recorded force and timing.