A compound of formula, wherein A is selected from B represents -NH-C -R 23, -NH-SO 2 -R 23 C represents -H, -OH; D represents R 10 represents -H, -CH 3, -OCH 3, -F, -Cl, -Br, -I; R 11 represents -H, -OR 20, -OCH 2 R 19, -CO 2 H, -CH 2 OH, -CO 2 CH 3, -NH 2, -NH-C -CH 3, R 12 is selected from -H, -CH 3, -OCH 3, R 13 and R 26 are independently of each other -H, -CH 3, -C CH 3; R 14, R 15, R 16, R 17 and R 18 are independently of each other selected from: -H, -OH, -NH 2, -OCH 3, -OC 2 H 5, -CH 3, -O-C -NH 2, -O-C -NHR 22, -C 2 H 4 -S 2 (OCH 3), -C 2 H 4 -P (OCH 3) 2, -CH 2 -O-C CH 3, -CH 2 -NH-S 2 -OCH 3, R 19 represents -CH 2 -NH 2, -CH 2 -NHCH 3, -CH -CH 2, R 20 represents -H, -C -CH 3, -C -C 2 H 5, -C -C 3 H 7, -C -NH 2, -C -NH-CH 3, -C -NH-C 2 H 5, -SO 2 (CH 3), R 21 represents -H, -OH, -SH, -CH 3, -C 2 H 5, -F, -Cl, -Br, -I; R 22 represents -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, R 23 represents -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, -CH 2 -Ph, -C 2 H 4 -Ph, -O-CH 2 -Ph, R 24 and R 25 are independently of each other selected from -H, -OH, -OCH 3, -OC 2 H 5, -OPh, -O-CH 2 -Ph, -CH 2 -Ph, -C 2 H 4 -Ph, -NH 2, -NO 2, -CH 2 -CH=C(CH 3) 2, -CH=CHPh, -F, -CI, -Br, -I, -CN, -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, -OCF 3, -CF 3, -C(CH 3) 3, -Ph, R 24 together with R 25 can form together with the 2 aromatic carbons they are connected to a cycle selected from: E represents -O-, -S-, -NH-, -CH 2 -, or -OCH 2 -; R 1, R 2, R 3, R 4, R 6, R 7 and R 8 represent independently of each other -H, -OH, -OCH 3, or -OC 2 H 5; R 5 represents -H or -OR 9; R 9 represents -H, -CH 3, -C 2 H 5, -βGlc, -βGal, -βMal, or -βLac; and enantiomers, stereoisomeric forms, mixtures of enantiomers, diastereomers, mixtures of diastereomers, hydrates, solvates, acid salt forms, tautomers, and racemates of the above mentioned compounds and pharmaceutically acceptable salts thereof for use in inhibiting the production of hormones in hormone-producing pituitary adenoma, wherein the hormone-producing pituitary adenoma is selected from corticotroph adenoma, lactotroph adenoma, somatotroph adenoma and thyrotroph adenoma. A is selected from B represents -NH-C -R 23, -NH-SO 2 -R 23 C represents -H, -OH; D represents R 10 represents -H, -CH 3, -OCH 3, -F, -Cl, -Br, -I; R 11 represents -H, -OR 20, -OCH 2 R 19, -CO 2 H, -CH 2 OH, -CO 2 CH 3, -NH 2, -NH-C -CH 3, R 12 is selected from -H, -CH 3, -OCH 3, R 13 and R 26 are independently of each other -H, -CH 3, -C CH 3; R 14, R 15, R 16, R 17 and R 18 are independently of each other selected from: -H, -OH, -NH 2, -OCH 3, -OC 2 H 5, -CH 3, -O-C -NH 2, -O-C -NHR 22, -C 2 H 4 -S 2 (OCH 3), -C 2 H 4 -P (OCH 3) 2, -CH 2 -O-C CH 3, -CH 2 -NH-S 2 -OCH 3, R 19 represents -CH 2 -NH 2, -CH 2 -NHCH 3, -CH -CH 2, R 20 represents -H, -C -CH 3, -C -C 2 H 5, -C -C 3 H 7, -C -NH 2, -C -NH-CH 3, -C -NH-C 2 H 5, -SO 2 (CH 3), R 21 represents -H, -OH, -SH, -CH 3, -C 2 H 5, -F, -Cl, -Br, -I; R 22 represents -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, R 23 represents -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, -CH 2 -Ph, -C 2 H 4 -Ph, -O-CH 2 -Ph, R 24 and R 25 are independently of each other selected from -H, -OH, -OCH 3, -OC 2 H 5, -OPh, -O-CH 2 -Ph, -CH 2 -Ph, -C 2 H 4 -Ph, -NH 2, -NO 2, -CH 2 -CH=C(CH 3) 2, -CH=CHPh, -F, -CI, -Br, -I, -CN, -CH 3, -C 2 H 5, -C 3 H 7, -C 4 H 9, -OCF 3, -CF 3, -C(CH 3) 3, -Ph, R 24 together with R 25 can form together with the 2 aromatic carbons they are connected to a cycle selected from: E represents -O-, -S-, -NH-, -CH 2 -, or -OCH 2 -; R 1, R 2, R 3, R 4, R 6, R 7 and R 8 represent independently of each other -H, -OH, -OCH 3, or -OC 2 H 5; R 5 represents -H or -OR 9; R 9 represents -H, -CH 3, -C 2 H 5, -βGlc, -βGal, -βMal, or -βLac; and enantiomers, stereoisomeric forms, mixtures of enantiomers, diastereomers, mixtures of diastereomers, hydrates, solvates, acid salt forms, tautomers, and racemates of the above mentioned compounds and pharmaceutically acceptable salts thereof for use in inhibiting the production of hormones in hormone-producing pituitary adenoma, wherein the hormone-producing pituitary adenoma is selected from corticotroph adenoma, lactotroph adenoma, somatotroph adenoma and thyrotroph adenoma.