mhurhangee/ep-ind-claims huggingface dataset:
A chimeric antigen receptor having antigenic specificity for CD70, the CAR comprising: an antigen binding - transmembrane domain comprising a CD27 amino acid sequence lacking all of the CD27 intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and one or both of (i) a 4-1BB intracellular T cell signaling domain and (ii) a CD28 intracellular T cell signaling domain. an antigen binding - transmembrane domain comprising a CD27 amino acid sequence lacking all of the CD27 intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and one or both of (i) a 4-1BB intracellular T cell signaling domain and (ii) a CD28 intracellular T cell signaling domain.
A brake control device, comprising: - a necessary brake force acquisition unit adapted to acquire a necessary brake force necessary for each car or flatcar of a train containing a plurality of motor cars holding a primary electric motor; - an electric brake force detection unit adapted to detect an electric brake force of an entire composition of the train, the entire composition including the plurality of the motor cars; - a brake force adjustment unit adapted to distribute air brake force so as to compensate for fluctuations in the electric brake force with the air brake force of one of the cars or flatcars, in the action period of one deceleration of the train or from running to stopping; and - a control unit adapted to control an air brake force of each car or flatcar in accordance with a value distributed by the brake force adjustment unit, characterized in that the brake force adjustment unit is adapted to distribute an air brake force in such a manner that fluctuations in the electric brake force are compensated for by an air brake device of only one car or flatcar at any one point in time. - a necessary brake force acquisition unit adapted to acquire a necessary brake force necessary for each car or flatcar of a train containing a plurality of motor cars holding a primary electric motor; - an electric brake force detection unit adapted to detect an electric brake force of an entire composition of the train, the entire composition including the plurality of the motor cars; - a brake force adjustment unit adapted to distribute air brake force so as to compensate for fluctuations in the electric brake force with the air brake force of one of the cars or flatcars, in the action period of one deceleration of the train or from running to stopping; and - a control unit adapted to control an air brake force of each car or flatcar in accordance with a value distributed by the brake force adjustment unit, characterized in that the brake force adjustment unit is adapted to distribute an air brake force in such a manner that fluctuations in the electric brake force are compensated for by an air brake device of only one car or flatcar at any one point in time.
A vacuum pump that receives supply of a purge gas from a purge gas supply device (100, 110, 121, 122) connected thereto comprising: a temperature sensor unit disposed in a purge gas flow path for the supplied purge gas, the temperature sensor unit measuring a temperature of a rotating portion (8, 9, 10); a stator column that accommodates an electrical unit (11, 12, 13) for rotating the rotating portion (8, 9, 10; a base for fixing the stator column; characterized in that the vacuum pump further comprises: a throttle portion (21, 31) provided in at least a part of the purge gas flow path at a downstream side of the temperature sensor unit, the throttle portion (21, 31) controlling the purge gas flow path in one direction, the throttle portion (21, 31) being either included in the stator column and having an outer diameter larger than the base, or being included in the base and having an outer diameter larger than the stator column; and a thread groove-type seal for causing at least some of the purge gas to flow back toward the temperature sensor unit, the thread groove-type seal being provided on a downstream side of the purge gas flow path in which the temperature sensor unit is disposed. a temperature sensor unit disposed in a purge gas flow path for the supplied purge gas, the temperature sensor unit measuring a temperature of a rotating portion (8, 9, 10); a stator column that accommodates an electrical unit (11, 12, 13) for rotating the rotating portion (8, 9, 10; a base for fixing the stator column; a throttle portion (21, 31) provided in at least a part of the purge gas flow path at a downstream side of the temperature sensor unit, the throttle portion (21, 31) controlling the purge gas flow path in one direction, the throttle portion (21, 31) being either included in the stator column and having an outer diameter larger than the base, or being included in the base and having an outer diameter larger than the stator column; and a thread groove-type seal for causing at least some of the purge gas to flow back toward the temperature sensor unit, the thread groove-type seal being provided on a downstream side of the purge gas flow path in which the temperature sensor unit is disposed.
A walking aid having at its ground-engaging end a generally transverse end wall, formed on an end piece, wherein the end piece is fitted to a lower end of a shaft, and wherein the end piece, intermediate the portion fitted on to the shaft and the transverse ground-engaging end wall, incorporate a resilient section which is both axially compressible and laterally bendable whereby to enable the grounding-engaging end wall to, in use, lie flat against a surface with the shaft at an angle not normal thereto and simultaneously to absorb resiliently an axial load applied to the shaft, wherein the resilient section comprises a pleated bellows (2, 24, 50, 60, 70) having a high degree of lateral stability due to the stiffness of the pleats but where the hinge points between the pleats allow a large amount of vertical movement, and characterised in that the bellows section (50, 60, 70) is sealed and is located intermediate a socket designed to fit on to the shaft and a ground-engaging foot member (51, 63) designed to contact the surface of the ground.
Method for producing enteric calcium alginate microcapsules with a homogeneous composition containing diclofenac or one of the salts thereof, CHARACTERIZED in that it comprises the following steps: A) preparing a solution of an alginate salt, selected from sodium, potassium or ammonium alginate, in water-ethanol and dissolving under stirring diclofenac or one of the salts thereof in the presence of a surfactant selected from the group formed by sorbitan monostearate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan monolaurate, and sodium bicarbonate, at a temperature under 60°C; B) adding the solution obtained in A) to a solution of calcium chloride controlling the temperature under 60°C, throughout the process; C) resuspending the microcapsules formed and isolated without previous drying in a solution of said alginate salt, at a concentration of between 0.05% and 0.1%, under stirring for 30 to 120 minutes at ambient temperature; D) separating by filtering, drying and sieving successively through 1000 and 250 micron meshes, selecting for producing the pharmaceutical composition only the fraction of microcapsules obtained and sized between both meshes, wherein the microcapsules obtained and selected have an active ingredient content higher than 55%; E) and optionally, converting the microcapsules thus obtained into prolonged release microcapsules. A) preparing a solution of an alginate salt, selected from sodium, potassium or ammonium alginate, in water-ethanol and dissolving under stirring diclofenac or one of the salts thereof in the presence of a surfactant selected from the group formed by sorbitan monostearate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan monolaurate, and sodium bicarbonate, at a temperature under 60°C; B) adding the solution obtained in A) to a solution of calcium chloride controlling the temperature under 60°C, throughout the process; C) resuspending the microcapsules formed and isolated without previous drying in a solution of said alginate salt, at a concentration of between 0.05% and 0.1%, under stirring for 30 to 120 minutes at ambient temperature; D) separating by filtering, drying and sieving successively through 1000 and 250 micron meshes, selecting for producing the pharmaceutical composition only the fraction of microcapsules obtained and sized between both meshes, wherein the microcapsules obtained and selected have an active ingredient content higher than 55%; E) and optionally, converting the microcapsules thus obtained into prolonged release microcapsules.
An allergen composition comprising an inhalation allergen or a venom allergen associated with IgE-mediated allergy, formulated to be suitable for subcutaneous administration, for use in subcutaneous specific allergen immunotherapy, which comprises an up-dosing phase and a maintenance phase, and a dose of the allergen composition in the up-dosing phase is administered to an individual in need thereof by use of subcutaneous infusion using a continuous flow at a flow rate not exceeding 0.05 ml/min within a period in the range of 5 to 180 minutes and wherein the up-dosing has a duration of 2-6 weeks and the number of administrations of single doses in the up-dosing phase is from 2-4.
A method for using a mashup service, comprising: Receiving, by a mashup service server, a request for using the mashup service, wherein the request includes user information and access information of a mashup service terminal; invoking, by the mashup service server, capability of a mashup service terminal according to the request; and invoking, by the mashup service server, Web service and telecommunication network service according to the request; wherein the invoking the capability of the mashup service terminal comprises: requesting, by the mashup service server, security information from a security gateway; returning, by the security gateway, the security information; sending, by the mashup service server, a capability request message to the mashup service terminal, wherein the capability request message includes the security information; applying, by the mashup service terminal, to the security gateway for authenticating the security information; returning, by the security gateway, a security information authentication result; and if authentication is passed, invoking the capability of the mashup service terminal. Receiving, by a mashup service server, a request for using the mashup service, wherein the request includes user information and access information of a mashup service terminal; invoking, by the mashup service server, capability of a mashup service terminal according to the request; and invoking, by the mashup service server, Web service and telecommunication network service according to the request; wherein the invoking the capability of the mashup service terminal comprises: requesting, by the mashup service server, security information from a security gateway; returning, by the security gateway, the security information; sending, by the mashup service server, a capability request message to the mashup service terminal, wherein the capability request message includes the security information; applying, by the mashup service terminal, to the security gateway for authenticating the security information; returning, by the security gateway, a security information authentication result; and if authentication is passed, invoking the capability of the mashup service terminal. requesting, by the mashup service server, security information from a security gateway; returning, by the security gateway, the security information; sending, by the mashup service server, a capability request message to the mashup service terminal, wherein the capability request message includes the security information; applying, by the mashup service terminal, to the security gateway for authenticating the security information; returning, by the security gateway, a security information authentication result; and if authentication is passed, invoking the capability of the mashup service terminal.
A Hall effect thruster comprising at least one tank of gas under high pressure, a pressure regulator module, a gas flow rate control device, an ionization channel, at least one cathode (40A, 40B) placed in the vicinity of the outlet from the ionization channel, an anode associated with the ionization channel, an electrical power supply unit, an electric filter, and coils (31, 32) for creating a magnetic field around the ionization channel, the thruster being characterized in that it further comprises an additional electrical power supply unit for applying a pulsating voltage between said anode and said at least one cathode (40A, 40B) and in that the additional electrical power supply unit produces in alternation a first discharge voltage (Ud min) for a first duration (t tot - t j/A) lying in the range 5 μs to 15 μs, and a second discharge voltage (Ud max) for a second duration (t j/A) lying in the range 5 μs to 15 μs.
Sanitary fitting having - at least one water outlet, - a valve for selectively permitting and preventing the outflow of water from the at least one water outlet, - an actuating unit for actuating the valve and - a display device, - wherein the actuating unit actuates the valve over at least one permitting period to permit outflow from the water outlet and - wherein the remaining permitting time for which outflow from the water outlet is still permitted during a permitting period is displayable on the display device and - the display device and/or an operating device are connected to the sanitary fitting with the aid of wireless signal transmission. - at least one water outlet, - a valve for selectively permitting and preventing the outflow of water from the at least one water outlet, - an actuating unit for actuating the valve and - a display device, - wherein the actuating unit actuates the valve over at least one permitting period to permit outflow from the water outlet and - wherein the remaining permitting time for which outflow from the water outlet is still permitted during a permitting period is displayable on the display device and - the display device and/or an operating device are connected to the sanitary fitting with the aid of wireless signal transmission.
A method for connecting a twisted wire, formed by twisting a plurality of core wires, and a wire material, characterised by: - a first step of hardening the twisted wire by applying ultrasonic vibration from a top surface thereof using a pressurized vibration tool, and - a second step of directly bonding the twisted wire having been hardened and the wire material by applying ultrasonic waves with the surface of the twisted wire, contacted in the first step with the vibration tool, kept in contact with the wire material, wherein, in the second step, ultrasonic waves are applied to the opposite side of the hardened surface of the twisted wire by pressuring with the vibration tool, wherein the first step and the second step use the same vibration tool, and the twisted wire is reversed after the first step but before the second step; and such that the twisted wire, on a cross section connected to the wire material, has a plurality of core wires configuring the twisted wire bonded and hardened on a first face which is connected to the wire material and a second face which is on the opposite side and which has a unification of the core wires similar to that of the first face, and the core wires in a region between the first face and the second face have not been unified, wherein a binding force of the core wires in the region between the first face and the second face is lower than on the first face and the second face. - a first step of hardening the twisted wire by applying ultrasonic vibration from a top surface thereof using a pressurized vibration tool, and - a second step of directly bonding the twisted wire having been hardened and the wire material by applying ultrasonic waves with the surface of the twisted wire, contacted in the first step with the vibration tool, kept in contact with the wire material, wherein, in the second step, ultrasonic waves are applied to the opposite side of the hardened surface of the twisted wire by pressuring with the vibration tool, wherein the first step and the second step use the same vibration tool, and the twisted wire is reversed after the first step but before the second step; and such that the twisted wire, on a cross section connected to the wire material, has a plurality of core wires configuring the twisted wire bonded and hardened on a first face which is connected to the wire material and a second face which is on the opposite side and which has a unification of the core wires similar to that of the first face, and the core wires in a region between the first face and the second face have not been unified, wherein a binding force of the core wires in the region between the first face and the second face is lower than on the first face and the second face.
A device for supporting micro-tools, wherein the micro-tool has a front portion with a cutting end edge, a rear portion with a substantially cylindrical outer surface, and a flattening formed at the rear portion; which device comprises: - an elongated body defining a longitudinal axis and having a housing hole provided with a center to allow at least partially insertion of the rear portion of the tool with a predetermined radial clearance; - constraint means associated to said elongated body and designed to interact with the substantially cylindrical outer surface of the rear portion to define a reference position for the cutting end edge of the tool; - locking means associated to said elongated body and designed to interact with the flattening formed on the rear portion of the tool to allow the selective locking thereof in reference position; wherein said constraint means comprise at least a passage intersecting said housing hole and substantially parallel thereto, and a corresponding at least one pin designed to be inserted into said at least one passage and having a peripheral surface adapted to selectively interact with the outer surface of the rear portion of the tool to define therewith a substantially continuous contact area which extends along the elongated direction of said pin; characterized in that each pin is coupled to a respective passage by interference and is locked with respect to a substantially transversal direction to define a substantially constant and fixed position of said contact area with respect the center of said housing hole. - an elongated body defining a longitudinal axis and having a housing hole provided with a center to allow at least partially insertion of the rear portion of the tool with a predetermined radial clearance; - constraint means associated to said elongated body and designed to interact with the substantially cylindrical outer surface of the rear portion to define a reference position for the cutting end edge of the tool; - locking means associated to said elongated body and designed to interact with the flattening formed on the rear portion of the tool to allow the selective locking thereof in reference position;
A work area management method, comprising: determining a first work area in a field for determining a first work route along which a first work device can move to perform a first work in the field, on the basis of a positioning position of the first work device moving in the field, storing first area information that represents the first work area, determining the first work route along which the first work device can move to perform the first work in the field; and outputting the first area information as information that represents an area for determining a second work route along which a second work device different from the first work device can move to perform a second work in the field, determining the second work route along which the second work device can move to perform a second work in the field, characterized in that the outputting the first area information includes outputting warning information to inform an operator, the outputting warning information representing that the first area information is unsuitable for determining the second work route when the first area information does not satisfy a predetermined condition. determining a first work area in a field for determining a first work route along which a first work device can move to perform a first work in the field, on the basis of a positioning position of the first work device moving in the field, storing first area information that represents the first work area, determining the first work route along which the first work device can move to perform the first work in the field; and outputting the first area information as information that represents an area for determining a second work route along which a second work device different from the first work device can move to perform a second work in the field, determining the second work route along which the second work device can move to perform a second work in the field,
An electrical switch comprising an electronic board and a push-button for manual pressing, the electronic board extending parallel to the push-button with electrical components on a rear face of the electronic board, the front face of the electronic board carrying a switch placed to be actuated by the push-button, the electrical switch being such that the push-button is formed integrally with on the one hand a sealing lip bearing on the front face of the electronic board around the switch, and on the other hand hooks retaining the board against said sealing lip.
A method for identifying a free fatty acid or LDL in a liquid, comprising: placing said liquid on a water-repellant surface as a droplet; obtaining a magnified image from an image of said droplet; obtaining a contact diameter (do) from said magnified image; obtaining a contact diameter, d ( t), after the lapse of predetermined time ( t) from said magnified image; and calculating a contact area diffusion factor (CADF) by substituting said d ( t) and do for the following equation 1; CADF = d t 2 − d 0 2 d 0 2 × 100 where d ( t) is the contact diameter of said droplet after the lapse of time, t, and d 0 is the initial contact diameter, and; said free fatty acid or LDL is determined to be present in said liquid when the value of CADF is positive. placing said liquid on a water-repellant surface as a droplet; obtaining a magnified image from an image of said droplet; obtaining a contact diameter (do) from said magnified image; obtaining a contact diameter, d ( t), after the lapse of predetermined time ( t) from said magnified image; and calculating a contact area diffusion factor (CADF) by substituting said d ( t) and do for the following equation 1; CADF = d t 2 − d 0 2 d 0 2 × 100 where d ( t) is the contact diameter of said droplet after the lapse of time, t, and d 0 is the initial contact diameter, and; said free fatty acid or LDL is determined to be present in said liquid when the value of CADF is positive.