mhurhangee/ep-ind-claims huggingface dataset:
A protein comprising (i) a signal peptide; (ii) a target specific recognition domain; (iii) a linker region, connecting domain (ii) and domain (iv), wherein the linker region does not contain cysteine residue(s) and is selected from any of the following: the amino acid sequence of SEQ ID NO. 2, an amino acid sequence with at least 95 % sequence identity to SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine, and an amino acid sequence that differs in one, two or three amino acid residues from the amino acid sequence of SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine; and (iv) an effector domain comprising a transmembrane region and one or more intracellular signaling domains, wherein the effector domain (iv) comprises or is the transmembrane domain and the intracellular domain of the zeta-chain of the human CD3 complex of the T-cell receptor with the amino acid sequence encoded by the nucleotide sequence of SEQ ID NO. 9. (i) a signal peptide; (ii) a target specific recognition domain; (iii) a linker region, connecting domain (ii) and domain (iv), wherein the linker region does not contain cysteine residue(s) and is selected from any of the following: the amino acid sequence of SEQ ID NO. 2, an amino acid sequence with at least 95 % sequence identity to SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine, and an amino acid sequence that differs in one, two or three amino acid residues from the amino acid sequence of SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine; and the amino acid sequence of SEQ ID NO. 2, an amino acid sequence with at least 95 % sequence identity to SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine, and an amino acid sequence that differs in one, two or three amino acid residues from the amino acid sequence of SEQ ID NO. 2 under the proviso that amino acid residue 48 is not a cysteine and is a serine; and (iv) an effector domain comprising a transmembrane region and one or more intracellular signaling domains, wherein the effector domain (iv) comprises or is the transmembrane domain and the intracellular domain of the zeta-chain of the human CD3 complex of the T-cell receptor with the amino acid sequence encoded by the nucleotide sequence of SEQ ID NO. 9.
Transflective liquid crystal display comprising one or more pixels that are divided into a reflective and a transmissive subpixel and comprise • an LC layer sandwiched between a front and a back electrode, being switchable between different orientations upon application of an electric field and having a twist angle φ when no field is applied, • a front and a back polariser sandwiching the LC layer and having front and back polarisation directions, • at least one quarter wave retardation film between the front polariser and the LC layer, which has an optical axis parallel to its film plane, comprises a pattern of regions with quarter wave (λ/4) retardation and regions with substantially no retardation, and is arranged such that the λ/4-regions do essentially cover only the reflective subpixels, characterized in that • the optical axis of the QWF is oriented at an angle of approximately 45° to the front and back polariser direction, • the director of the LC layer at the surface facing the front electrode is oriented at an angle θ1 of from 10° to 20° relative to the polarisation direction of the front polariser, and • the director of the LC layer at the surface facing the back electrode is oriented at an angle θ2 of from 10° to 20° relative to the polarisation direction of the back polariser. • an LC layer sandwiched between a front and a back electrode, being switchable between different orientations upon application of an electric field and having a twist angle φ when no field is applied, • a front and a back polariser sandwiching the LC layer and having front and back polarisation directions, • at least one quarter wave retardation film between the front polariser and the LC layer, which has an optical axis parallel to its film plane, comprises a pattern of regions with quarter wave (λ/4) retardation and regions with substantially no retardation, and is arranged such that the λ/4-regions do essentially cover only the reflective subpixels, characterized in that • the optical axis of the QWF is oriented at an angle of approximately 45° to the front and back polariser direction, • the director of the LC layer at the surface facing the front electrode is oriented at an angle θ1 of from 10° to 20° relative to the polarisation direction of the front polariser, and • the director of the LC layer at the surface facing the back electrode is oriented at an angle θ2 of from 10° to 20° relative to the polarisation direction of the back polariser.
An infusion set adapted to be secured to a skin surface, comprising: a fixed base member connectable to the skin surface; a movable slide member located inside the fixed base member having a needle or cannula connected thereto and movable relative to said fixed base member, to insert the needle or cannula at an angle relative to a skin surface via a user motion, the angle of user motion being different from the angle of the inserted needle or cannula, to target and deliver insulin or other medicament to the upper 3 mm of skin surface, said movable slide member being movable from a first position in which said needle or cannula is not exposed externally of said fixed base member to a second position in which said needle or cannula is exposed externally of said fixed base member, said movable slide member being locked to said fixed base member in said second position; and said fixed base member comprising longitudinally extending base members (87,88) for engaging locking feet (74,75) of an inserter according to claim 5 to prevent removal of said inserter from said fixed base member when said moveable slide member is in said first position and to allow said inserter to be released from said fixed base member when said moveable slide member reaches said second position and said locking feet (74,75) extend past and are clear of said longitudinally extending base members (87,88). a fixed base member connectable to the skin surface; a movable slide member located inside the fixed base member having a needle or cannula connected thereto and movable relative to said fixed base member, to insert the needle or cannula at an angle relative to a skin surface via a user motion, the angle of user motion being different from the angle of the inserted needle or cannula, to target and deliver insulin or other medicament to the upper 3 mm of skin surface, said movable slide member being movable from a first position in which said needle or cannula is not exposed externally of said fixed base member to a second position in which said needle or cannula is exposed externally of said fixed base member, said movable slide member being locked to said fixed base member in said second position; and said fixed base member comprising longitudinally extending base members (87,88) for engaging locking feet (74,75) of an inserter according to claim 5 to prevent removal of said inserter from said fixed base member when said moveable slide member is in said first position and to allow said inserter to be released from said fixed base member when said moveable slide member reaches said second position and said locking feet (74,75) extend past and are clear of said longitudinally extending base members (87,88).
A method, comprising the step of contacting a genetically engineered microorganism with a substrate, wherein the genetically engineered microorganism has been transformed by a nucleic acid molecule comprising a non-native gene, wherein the non-native gene is ptxD; wherein the substrate comprises a phosphorus-containing fraction and a non-phosphorus-containing fraction; the phosphorus-containing fraction comprises, in an amount from about 10% by weight to about 100% by weight, a phosphorus-containing compound of Formula I; the compound of formula I is wherein, independently for each occurrence, R is -H, -OH, alkyl, -OR 2, -SH, or -SR 2; R 1 is -H, or alkyl; Y is O or S; Y 1 is O or S; and R 2 is alkyl; a native microorganism of the same species as the genetically engineered organism could not metabolize (i.e., use as a source of phosphorus) the phosphorus-containing compound; wherein the genetically engineered microorganism is a bacterium or yeast; and wherein the genetically engineered organism is contacted with the substrate in an industrial-size fermentor and the genetically engineered microorganism converts the substrate to a product, wherein the product is ethanol, isopropanol, lactic acid, an isoprenoid, a lipid, butanol, 1,3-propanediol, 1,4-butanediol, succinic acid, an expressed protein product, an enzyme product, a polyol, a pharmaceutical product, itaconic acid, or a high value specialty chemical. R is -H, -OH, alkyl, -OR 2, -SH, or -SR 2; R 1 is -H, or alkyl; Y is O or S; Y 1 is O or S; and R 2 is alkyl;
A method for transmitting a hybrid automatic repeat request, HARQ-ACK, payload by a user equipment, UE, in a 3rd generation partnership project, 3GPP, carrier aggregation, CA, wireless communication system, the method comprising: receiving a first physical downlink control channel, PDCCH, including a first downlink assignment index, DAI, and a second DAI in a subframe, SF within a bundling window, wherein the bundling window contains a plurality of subframes corresponding to a plurality of CA cells; receiving downlink, DL, data in the bundling window based on the first PDCCH; configuring the HARQ-ACK payload for the DL data using the first DAI and the second DAI; and transmitting the HARQ-ACK payload in an uplink, UL, SF associated with the bundling window, characterized in that the value of the first DAI indicates a scheduling order value in units of cell/SF associated with the first PDCCH, the scheduling order value in units of cell/SF being counted in order of increasing firstly a cell index and then increasing secondly an SF index in the SFs scheduled by PDCCHs in the bundling window, and the value of the second DAI for each SF is obtained by accumulating in units of SF, the number of cells scheduled for the UE by PDCCHs, by starting accumulating scheduled cells in the first scheduled SF in the bundling window and continuing accumulating on a SF dimension until ending accumulating scheduled cells of each scheduled SF in the bundling window. receiving a first physical downlink control channel, PDCCH, including a first downlink assignment index, DAI, and a second DAI in a subframe, SF within a bundling window, wherein the bundling window contains a plurality of subframes corresponding to a plurality of CA cells; receiving downlink, DL, data in the bundling window based on the first PDCCH; configuring the HARQ-ACK payload for the DL data using the first DAI and the second DAI; and transmitting the HARQ-ACK payload in an uplink, UL, SF associated with the bundling window, characterized in that the value of the first DAI indicates a scheduling order value in units of cell/SF associated with the first PDCCH, the scheduling order value in units of cell/SF being counted in order of increasing firstly a cell index and then increasing secondly an SF index in the SFs scheduled by PDCCHs in the bundling window, and the value of the second DAI for each SF is obtained by accumulating in units of SF, the number of cells scheduled for the UE by PDCCHs, by starting accumulating scheduled cells in the first scheduled SF in the bundling window and continuing accumulating on a SF dimension until ending accumulating scheduled cells of each scheduled SF in the bundling window.
An apparatus for locating a curvilinear cut in a bone, the apparatus comprising: a jig body; a first arm, a first end of which is rotatably coupleable to a first portion of the jig body; a second arm, a first end of which is rotatably coupleable to a second portion of the jig body separated from the first portion; and a saw guide rotatably coupleable to the first arm, wherein the saw guide includes a first side extending along a curve corresponding to a desired path through which a bone is to be cut, characterized in that the saw guide includes a locking feature (208, 208', 208") for receiving a bone fixation element which, in an operative configuration, can be mounted in the bone to align the saw guide relative to the first arm so that an operator may precisely align a desired axis of the saw guide with a longitudinal axis of the first arm; wherein the jig body includes an orientation feature formed flush to a surface which, when the jig body is coupled to a bone in a desired orientation, extends in a plane substantially perpendicular to a plane within which the first and second arms extend from the jig body and wherein the orientation feature is an opening in the surface substantially perpendicular to the plane within which the first and second arms extend from the jig body. a jig body; a first arm, a first end of which is rotatably coupleable to a first portion of the jig body; a second arm, a first end of which is rotatably coupleable to a second portion of the jig body separated from the first portion; and a saw guide rotatably coupleable to the first arm, wherein the saw guide includes a first side extending along a curve corresponding to a desired path through which a bone is to be cut, characterized in that the saw guide includes a locking feature (208, 208', 208") for receiving a bone fixation element which, in an operative configuration, can be mounted in the bone to align the saw guide relative to the first arm so that an operator may precisely align a desired axis of the saw guide with a longitudinal axis of the first arm; wherein the jig body includes an orientation feature formed flush to a surface which, when the jig body is coupled to a bone in a desired orientation, extends in a plane substantially perpendicular to a plane within which the first and second arms extend from the jig body and wherein the orientation feature is an opening in the surface substantially perpendicular to the plane within which the first and second arms extend from the jig body.
A cylinder composed of a metallic material or of plastic for a reciprocating piston engine with a crank drive, in particular with a Scotch yoke mechanism, having at least one cylinder barrel having a cylinder bore and having at least one cylinder liner made of ceramic material that is supported in the cylinder bore, with the cylinder liner being glued in the cylinder bore, characterized in that the cylinder bore has a respective right-hand internal thread and left-hand internal thread.
A method for manufacturing a double-walled tube, wherein the method comprises: a) forming two extruded tubes, wherein one tube is arranged inside the other; b) providing a first mould around the outside of the outer tube and a support along the inside of the inner tube; and, c) injecting fluid into a first cavity between the inner and outer tubes to mould the outer tube against the first mould; and wherein at least some of the fluid is retained in the first cavity between the inner and outer tubes and wherein the fluid is, or comprises a component of, a substance that can be activated to act as a heat source or a coolant. a) forming two extruded tubes, wherein one tube is arranged inside the other; b) providing a first mould around the outside of the outer tube and a support along the inside of the inner tube; and, c) injecting fluid into a first cavity between the inner and outer tubes to mould the outer tube against the first mould; and wherein at least some of the fluid is retained in the first cavity between the inner and outer tubes and wherein the fluid is, or comprises a component of, a substance that can be activated to act as a heat source or a coolant.
Unloader for a compressor, said unloader comprising a housing with an inlet and an outlet, and whereby the unloader is further provided with a piston rod which is arranged moveably in a reciprocating manner in the housing, whereby on one end of the piston rod a valve is provided to be able to close the outlet and whereby on the other end of the piston rod a piston is arranged, the piston being arranged moveably in a reciprocating manner in a thereto provided cavity of the unloader, said cavity being at least partially delimited by a lid which is provided on the housing and which is also part of the unloader, whereby sealing means are provided for the leakage-free movement of the piston in said cavity, characterised in that the cavity in which the piston is arranged moveably in a reciprocating manner is completely located or integrated in the lid, and that the piston and the sealing means are freely accessible when the lid is removed.
A battery pack comprising: a first battery cell; a second battery cell; a frame accommodating the first and second battery cells; and a protective circuit module assembly, wherein the battery cells each comprise a respective electrode terminal and the frame comprises a hole, the location of the hole corresponding to the location of at least one of the electrode terminals; and wherein the frame comprises an inwardly directed spacer formation located between the first and second battery cells for spacing them from each other, the spacer formation comprises at least one flange; characterised in that the frame comprises two openings for allowing an electrode lead of the PCM assembly to make electrical contact with the two battery cells, and said openings are located on an opposite side of the frame to the said hole; the ends of said electrode lead of the PCM assembly are firmly connected by resistance or laser welding to the battery cells through the said openings via a side of the frame; and the frame comprises at least one rib (322, 332) extending between an inner surface thereof and the flange, the said rib having a profile that conforms to a surface of one of the first and second battery cells and serves as a seat for that surface. a first battery cell; a second battery cell; a frame accommodating the first and second battery cells; and a protective circuit module assembly,
A torch igniter fuel system for a combustor of a gas turbine engine, the torch igniter fuel system comprising: a housing defining a combustion chamber; an ignition source disposed at least partially in the combustion chamber; a fuel injector configured to inject at least one of fuel and air into the combustion chamber and to impinge on the ignition source; a first fluid path configured to connect a first fuel source to the fuel injector; a second fluid path configured to connect an air source to the fuel injector; a third fluid path configured to connect a second fuel source to the combustion chamber; wherein a portion of the second fluid path overlaps the third fluid path; wherein the torch igniter fuel system further comprises: an inner wall of the fuel injector that defines an internal volume of the fuel injector; a flow divider disposed within the internal volume of the fuel injector; a tip aperture disposed between the combustion chamber and the flow divider, wherein the first fluid path, second fluid path, and third fluid path overlap within the tip aperture; a channel that extends through the flow divider and connects the second fluid path and third fluid path to the tip aperture; and an annular volume formed between the flow divider and the inner wall that connects the first fluid path to the tip aperture. a housing defining a combustion chamber; an ignition source disposed at least partially in the combustion chamber; a fuel injector configured to inject at least one of fuel and air into the combustion chamber and to impinge on the ignition source; a first fluid path configured to connect a first fuel source to the fuel injector; a second fluid path configured to connect an air source to the fuel injector; a third fluid path configured to connect a second fuel source to the combustion chamber; wherein a portion of the second fluid path overlaps the third fluid path; wherein the torch igniter fuel system further comprises: an inner wall of the fuel injector that defines an internal volume of the fuel injector; a flow divider disposed within the internal volume of the fuel injector; a tip aperture disposed between the combustion chamber and the flow divider, wherein the first fluid path, second fluid path, and third fluid path overlap within the tip aperture; a channel that extends through the flow divider and connects the second fluid path and third fluid path to the tip aperture; and an annular volume formed between the flow divider and the inner wall that connects the first fluid path to the tip aperture. an inner wall of the fuel injector that defines an internal volume of the fuel injector; a flow divider disposed within the internal volume of the fuel injector; a tip aperture disposed between the combustion chamber and the flow divider, wherein the first fluid path, second fluid path, and third fluid path overlap within the tip aperture; a channel that extends through the flow divider and connects the second fluid path and third fluid path to the tip aperture; and an annular volume formed between the flow divider and the inner wall that connects the first fluid path to the tip aperture.
A method for manufacturing nanoholes, the method comprising: a preparing step of preparing a body having a through-hole which passes through two facing surfaces and has a nano-scale diameter, the body being an anodic aluminum oxide membrane; and a particle injecting step of injecting particles into the through-hole through an inlet of the through-hole to form nanoholes with a smaller size than the through-hole, wherein the inlet and an outlet opposite to the inlet, are formed in an asymmetric structure, wherein in the through-hole, the diameter of the inlet is larger than that of the outlet, the diameter of the inlet is larger than the diameter of the particles, and the diameter of the outlet is smaller than the diameter of the particles, so that the particles injected in the particle injecting step do not leave the through-hole through the outlet, wherein in the particle injecting step, the nanoholes are formed by pores between the particles, characterized in that a surface of the particles is positively or negatively charged so that an electrically charged electric double layer is formed on the surface of the particle or a region adjacent to the surface. a preparing step of preparing a body having a through-hole which passes through two facing surfaces and has a nano-scale diameter, the body being an anodic aluminum oxide membrane; and a particle injecting step of injecting particles into the through-hole through an inlet of the through-hole to form nanoholes with a smaller size than the through-hole, wherein the inlet and an outlet opposite to the inlet, are formed in an asymmetric structure, wherein in the through-hole, the diameter of the inlet is larger than that of the outlet, the diameter of the inlet is larger than the diameter of the particles, and the diameter of the outlet is smaller than the diameter of the particles, so that the particles injected in the particle injecting step do not leave the through-hole through the outlet, wherein in the particle injecting step, the nanoholes are formed by pores between the particles, characterized in that a surface of the particles is positively or negatively charged so that an electrically charged electric double layer is formed on the surface of the particle or a region adjacent to the surface.