An analyte test sensor, the test sensor comprising: at least two substrates forming a reservoir, the reservoir including a primary area and a plurality of nine secondary analysis regions including a region at the end of the primary area, each of the secondary analysis regions being occupied by an electrode or conductor, each of the secondary analysis regions being distinct and separate from each other and being substantially chemically isolated such that diffusive or convective mixing of reagent compositions does not substantially occur between the plurality of nine secondary analysis regions during the time of one or more analyses of a sample, - each one of four of the secondary analysis regions including a respective working electrodes, the four working electrodes being electrically connected, each of the working electrodes being formed from a reagent composition and a first conductor, - each one of four other secondary analysis regions including a respective counter electrode, the four counter electrodes being independently addressable, each of the counter electrodes being formed from a charge transfer system and a second conductor; at least one sample port in fluid communication with the reservoir; and a plurality of vents with each of the vents being in fluid communication with a respective one of the secondary analysis regions; wherein the four secondary analysis regions including the working electrodes are located on one side of the primary area, the four secondary analysis regions including the counter electrodes being located on an opposing side of the primary area in a staggered arrangement such that a straight line passing from one of the working electrodes through the respective secondary analysis region and through the primary area cannot be drawn through an opposing second secondary analysis region to a respective opposing, but staggered, counter electrode. at least two substrates forming a reservoir, the reservoir including a primary area and a plurality of nine secondary analysis regions including a region at the end of the primary area, each of the secondary analysis regions being occupied by an electrode or conductor, each of the secondary analysis regions being distinct and separate from each other and being substantially chemically isolated such that diffusive or convective mixing of reagent compositions does not substantially occur between the plurality of nine secondary analysis regions during the time of one or more analyses of a sample, - each one of four of the secondary analysis regions including a respective working electrodes, the four working electrodes being electrically connected, each of the working electrodes being formed from a reagent composition and a first conductor, - each one of four other secondary analysis regions including a respective counter electrode, the four counter electrodes being independently addressable, each of the counter electrodes being formed from a charge transfer system and a second conductor; - each one of four of the secondary analysis regions including a respective working electrodes, the four working electrodes being electrically connected, each of the working electrodes being formed from a reagent composition and a first conductor, - each one of four other secondary analysis regions including a respective counter electrode, the four counter electrodes being independently addressable, each of the counter electrodes being formed from a charge transfer system and a second conductor; at least one sample port in fluid communication with the reservoir; and a plurality of vents with each of the vents being in fluid communication with a respective one of the secondary analysis regions; wherein the four secondary analysis regions including the working electrodes are located on one side of the primary area, the four secondary analysis regions including the counter electrodes being located on an opposing side of the primary area in a staggered arrangement such that a straight line passing from one of the working electrodes through the respective secondary analysis region and through the primary area cannot be drawn through an opposing second secondary analysis region to a respective opposing, but staggered, counter electrode.