A therapeutic treatment system for controlled thermal injury in human superficial tissue within a region-of-interest, said treatment system comprising: a probe configured for both imaging and therapy at a depth below a skin surface, wherein the imaging is provided by an imaging element, wherein the therapy is provided by a therapy element, the probe comprising: at least one ultrasound imaging element configured for imaging the region-of-interest; a single ultrasound therapy element composed of one individual single-element transducer, configured for single focus and for treating said area of interest, the single ultrasound therapy element configured to emit acoustical energy at a frequency of between 1 MHz and 40 MHz for generating a conformal lesion having a pre-selected size, shape, and orientation within the region-of-interest at the depth of superficial human tissue between zero and 30 mm from a skin surface; and a motion mechanism in the probe for controllably creating a plurality of conformal lesions, a transducer probe housing for coupling to a tissue interface, wherein the probe is configured within the transducer probe housing; and control system to controllably produce the plurality of conformal lesions separated throughout the region-of-interest, the control system being in communication with and controlling said probe, said control system and said probe being configured for spatial and temporal control of acoustical energy within six degrees of freedom to generate the conformal lesion. a probe configured for both imaging and therapy at a depth below a skin surface, wherein the imaging is provided by an imaging element, wherein the therapy is provided by a therapy element, the probe comprising: at least one ultrasound imaging element configured for imaging the region-of-interest; a single ultrasound therapy element composed of one individual single-element transducer, configured for single focus and for treating said area of interest, the single ultrasound therapy element configured to emit acoustical energy at a frequency of between 1 MHz and 40 MHz for generating a conformal lesion having a pre-selected size, shape, and orientation within the region-of-interest at the depth of superficial human tissue between zero and 30 mm from a skin surface; and a motion mechanism in the probe for controllably creating a plurality of conformal lesions, a transducer probe housing for coupling to a tissue interface, wherein the probe is configured within the transducer probe housing; and at least one ultrasound imaging element configured for imaging the region-of-interest; a single ultrasound therapy element composed of one individual single-element transducer, configured for single focus and for treating said area of interest, the single ultrasound therapy element configured to emit acoustical energy at a frequency of between 1 MHz and 40 MHz for generating a conformal lesion having a pre-selected size, shape, and orientation within the region-of-interest at the depth of superficial human tissue between zero and 30 mm from a skin surface; and a motion mechanism in the probe for controllably creating a plurality of conformal lesions, a transducer probe housing for coupling to a tissue interface, wherein the probe is configured within the transducer probe housing; and control system to controllably produce the plurality of conformal lesions separated throughout the region-of-interest, the control system being in communication with and controlling said probe, said control system and said probe being configured for spatial and temporal control of acoustical energy within six degrees of freedom to generate the conformal lesion.