An ICU-special portable nebulization device for enabling autonomous respiration according to airflow, comprising a nebulization control host, a nebulization generator provided on the nebulization control host, and a tee connecting pipe provided on the nebulization generator; wherein the nebulization generator comprises a bottom housing, a medicinal solution tank provided on the bottom housing and spaced apart from a space of the bottom housing, a medicinal solution outlet provided on the bottom of the medicinal solution tank, an air guide port provided on the bottom housing at the same side as the medicinal solution outlet, a nozzle tube sheathed on the periphery of the medicinal solution outlet and the air guide port, a partition provided in the nozzle tube which separates the medicinal solution outlet and the air guide port, a nebulization sheet provided between the medicinal solution outlet and the nozzle tube, and a first circuit board provided in the bottom housing which is connected with the nebulization sheet; wherein the partition in the nozzle tube separates the interior of the nozzle tube into a nebulization cavity communicated with the medicinal solution outlet and an air cavity communicated with the air guide port; a sensor connected with the first circuit board is provided in the air cavity; wherein the nozzle tube on the side of the air cavity is provided with a cross-section stopper that blocks the opening of the air cavity, a first ventilation port and a second ventilation port communicated with the air cavity are respectively provided on two sides of the cross-section stopper; and wherein the first circuit board extends to the outside of the bottom housing and is connected with the nebulization generator. wherein the nebulization generator comprises a bottom housing, a medicinal solution tank provided on the bottom housing and spaced apart from a space of the bottom housing, a medicinal solution outlet provided on the bottom of the medicinal solution tank, an air guide port provided on the bottom housing at the same side as the medicinal solution outlet, a nozzle tube sheathed on the periphery of the medicinal solution outlet and the air guide port, a partition provided in the nozzle tube which separates the medicinal solution outlet and the air guide port, a nebulization sheet provided between the medicinal solution outlet and the nozzle tube, and a first circuit board provided in the bottom housing which is connected with the nebulization sheet; wherein the partition in the nozzle tube separates the interior of the nozzle tube into a nebulization cavity communicated with the medicinal solution outlet and an air cavity communicated with the air guide port; a sensor connected with the first circuit board is provided in the air cavity; wherein the nozzle tube on the side of the air cavity is provided with a cross-section stopper that blocks the opening of the air cavity, a first ventilation port and a second ventilation port communicated with the air cavity are respectively provided on two sides of the cross-section stopper; and wherein the first circuit board extends to the outside of the bottom housing and is connected with the nebulization generator.