Three-dimensional long-term active ingredient depot having a patient-individual fissure surface as three-dimensional replica of at least one part of a tooth of a dental restauration, wherein the outer dimensions of a single active ingredient depot do not exceed the dimensions of at least one molar and comprise a patient-individual replica of at least one part of a tooth, comprising A) a pharmaceutically active dental composition comprising (i) optionally, at least one excipient, and (ii) at least one active ingredient selected from antidementives, acetylcholinesterase inhibitors, levodopa, decarboxylase inhibitors, entacapone, selegiline, dopaminergic agonists, amantadine, anticholinergics, budipine, neuroleptics, antidepressants, anticonvulsants, lithium salts, antiarrhythmics, antidiabetics, proton pump inhibitors, antianginals, anti-inflammatory active ingredients, anti-viral active ingredients, antimycotics, antihistamines, chemotherapeutics, proteins, hormones and/or other pharmaceutically effective substances for the treatment of chronic diseases comprising dementia, Alzheimer's disease, Parkinson's disease, depressions, cardiovascular diseases, diabetes, osteoporosis, arthritis, gout and rheumatism, and combinations of at least two of the afore-mentioned active ingredients and/or substances, and B) at least one dental material, wherein and are present as at least partial mixture and the content (ii) of the at least one active ingredient is present in sum in the active ingredient depot with a content being sufficient for a defined, therapeutically effective dosage over a period of greater than or equal to one week, wherein the at least one dental material and/or the at least partial mixture of and comprises a) at least one acrylate polymer and optionally at least one filler or b) composite materials, denture plastics, veneer plastics, filling materials, cement materials, ceramic materials, silicate cements, Ca-cements, zinc-phosphate cements, glass ionomer cements, glass polyalkenoate cements, light-curing cements, cermet cements, composite cements, core build-ups, post build-ups, fissure sealants and veneer, wherein the mentioned dental materials may be selfadhesive or non-adhesive respectively and, as non-adhesive dental materials, are used with at least one dental adhesive, primer and/or bonding. A) a pharmaceutically active dental composition comprising (i) optionally, at least one excipient, and (ii) at least one active ingredient selected from antidementives, acetylcholinesterase inhibitors, levodopa, decarboxylase inhibitors, entacapone, selegiline, dopaminergic agonists, amantadine, anticholinergics, budipine, neuroleptics, antidepressants, anticonvulsants, lithium salts, antiarrhythmics, antidiabetics, proton pump inhibitors, antianginals, anti-inflammatory active ingredients, anti-viral active ingredients, antimycotics, antihistamines, chemotherapeutics, proteins, hormones and/or other pharmaceutically effective substances for the treatment of chronic diseases comprising dementia, Alzheimer's disease, Parkinson's disease, depressions, cardiovascular diseases, diabetes, osteoporosis, arthritis, gout and rheumatism, and combinations of at least two of the afore-mentioned active ingredients and/or substances, and (i) optionally, at least one excipient, and (ii) at least one active ingredient selected from antidementives, acetylcholinesterase inhibitors, levodopa, decarboxylase inhibitors, entacapone, selegiline, dopaminergic agonists, amantadine, anticholinergics, budipine, neuroleptics, antidepressants, anticonvulsants, lithium salts, antiarrhythmics, antidiabetics, proton pump inhibitors, antianginals, anti-inflammatory active ingredients, anti-viral active ingredients, antimycotics, antihistamines, chemotherapeutics, proteins, hormones and/or other pharmaceutically effective substances for the treatment of chronic diseases comprising dementia, Alzheimer's disease, Parkinson's disease, depressions, cardiovascular diseases, diabetes, osteoporosis, arthritis, gout and rheumatism, and combinations of at least two of the afore-mentioned active ingredients and/or substances, and B) at least one dental material, a) at least one acrylate polymer and optionally at least one filler or b) composite materials, denture plastics, veneer plastics, filling materials, cement materials, ceramic materials, silicate cements, Ca-cements, zinc-phosphate cements, glass ionomer cements, glass polyalkenoate cements, light-curing cements, cermet cements, composite cements, core build-ups, post build-ups, fissure sealants and veneer, wherein the mentioned dental materials may be selfadhesive or non-adhesive respectively and, as non-adhesive dental materials, are used with at least one dental adhesive, primer and/or bonding.