A variant of a parent D-psicose 3-epimerase, wherein the variant comprises or consists of: - the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 4 and having a residue Ser at position 211, or - the amino acid sequence of SEQ ID NO: 5 with a G211S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 5 and having a residue Ser at position 211; or - the amino acid sequence of SEQ ID NO: 6 with a G210S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 6 and having a residue Ser at position 210; or - the amino acid sequence of SEQ ID NO: 7 with a G211S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 7 and having a residue Ser at position 211; or - the amino acid sequence of SEQ ID NO: 8 with a G213S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 8 and having a residue Ser at position 213; or - the amino acid sequence of SEQ ID NO: 9 with a G223S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 9 and having a residue Ser at position 223; or - the amino acid sequence of SEQ ID NO: 10 with a G213S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 10 and having a residue Ser at position 213, wherein said variant has a D-psicose 3-epimerase activity, wherein the variant has one or several following features: a. a lower pH optimum compared to the parent D-psicose 3-epimerase, preferably in the range of 6 to 7; and/or b. a higher catalysis efficiency to the substrate D-fructose compared to the parent-psicose 3-epimerase, preferably at least twice higher; and/or c. a longer half-life at 60°C compared to the parent-psicose 3-epimerase, and wherein the parent D-psicose 3-epimerase is selected between SEQ ID NO:2 and 5-10. - the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 4 and having a residue Ser at position 211, or - the amino acid sequence of SEQ ID NO: 5 with a G211S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 5 and having a residue Ser at position 211; or - the amino acid sequence of SEQ ID NO: 6 with a G210S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 6 and having a residue Ser at position 210; or - the amino acid sequence of SEQ ID NO: 7 with a G211S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 7 and having a residue Ser at position 211; or - the amino acid sequence of SEQ ID NO: 8 with a G213S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 8 and having a residue Ser at position 213; or - the amino acid sequence of SEQ ID NO: 9 with a G223S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 9 and having a residue Ser at position 223; or - the amino acid sequence of SEQ ID NO: 10 with a G213S substitution or an amino acid sequence having 90 or 95 % or higher of identity with SEQ ID NO: 10 and having a residue Ser at position 213, a. a lower pH optimum compared to the parent D-psicose 3-epimerase, preferably in the range of 6 to 7; and/or b. a higher catalysis efficiency to the substrate D-fructose compared to the parent-psicose 3-epimerase, preferably at least twice higher; and/or c. a longer half-life at 60°C compared to the parent-psicose 3-epimerase,