A tissue clipping device (1200, 1300), comprising: a first member (1202, 1302); a plurality of arms (1210, 1310), each of the arms extending from a first end (1210p, 1310p) to a second end (1210d, 1310d), the first end of each arm being received within the first member (1202, 1302), the arms movable between an open configuration, in which the second ends (1210d, 1310d) of the arms are separated apart from one another, and a closed configuration, each of the arms (1210, 1310) including a spring portion (1216, 1316) configured to form a spring space between the spring portions (1216, 1316); a second member (1204, 1304) slidably disposed about the plurality of arms (1210, 1310), the second member having one or more channels (1226, 1326) internal to the second member that are engageable with opposing sloped surfaces of the arms (1210, 1310); wherein the first member (1202, 1302) and the second member (1302, 1304) are configured to be grasped from a plurality of angles relative to a longitudinal axis of the clipping device (1200, 1300), and are configured to be displaced relative to one another along the longitudinal axis of the clipping device (1200, 1300) in response to an application of a radially inwardly directed compressive force (1232, 1332); and wherein the one or more channels (1226, 1326) are moveable into and out of engagement with the opposing sloped surfaces of the arms (1210, 1310) when the first and second members (1202, 1204, 1302, 1304) are displaced relative to one another to transition the arms (1210, 1310) between the closed configuration and open configuration, wherein the first and second members (1202, 1204, 1302, 1304) include angled surfaces configured to displace the first and second members (1202, 1204, 1302, 1304) apart from one another when the compressive force (1232, 1332) is applied to the angled surfaces. a first member (1202, 1302); a plurality of arms (1210, 1310), each of the arms extending from a first end (1210p, 1310p) to a second end (1210d, 1310d), the first end of each arm being received within the first member (1202, 1302), the arms movable between an open configuration, in which the second ends (1210d, 1310d) of the arms are separated apart from one another, and a closed configuration, each of the arms (1210, 1310) including a spring portion (1216, 1316) configured to form a spring space between the spring portions (1216, 1316); a second member (1204, 1304) slidably disposed about the plurality of arms (1210, 1310), the second member having one or more channels (1226, 1326) internal to the second member that are engageable with opposing sloped surfaces of the arms (1210, 1310); wherein the first member (1202, 1302) and the second member (1302, 1304) are configured to be grasped from a plurality of angles relative to a longitudinal axis of the clipping device (1200, 1300), and are configured to be displaced relative to one another along the longitudinal axis of the clipping device (1200, 1300) in response to an application of a radially inwardly directed compressive force (1232, 1332); and wherein the one or more channels (1226, 1326) are moveable into and out of engagement with the opposing sloped surfaces of the arms (1210, 1310) when the first and second members (1202, 1204, 1302, 1304) are displaced relative to one another to transition the arms (1210, 1310) between the closed configuration and open configuration, wherein the first and second members (1202, 1204, 1302, 1304) include angled surfaces configured to displace the first and second members (1202, 1204, 1302, 1304) apart from one another when the compressive force (1232, 1332) is applied to the angled surfaces.