A compound of Formula or a stereoisomer, a geometric isomer, a tautomer, an N -oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof wherein: U is phenyl; each R 1 and R 2 is independently H, D, halogen, OH, NH 2, NO 2, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3-to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (=O), NH 2, NO 2 or CN; T is H, D, F, Cl, Br, NO 2, CN or CF 3; X is CR 4 or N; R 4 is H, D, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylamino or C 1-6 haloalkoxy; each of Y and Z is independently C, CH or N; " ----- " refers to a single bond or a double bond; Q is phene, C 4-7 carbocycle, 4- to 7-membered heterocycle or 5- to 6-membered heteroaromatic ring; each R 3 is independently H, D, halogen, oxo (=O), OH, NH 2, NO 2, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3-to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, 5- to 10-membered heteroaryl, phenyl, naphthyl or G, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3- to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, or 5- to 10-membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (=O), NH 2, NO 2, CN or G; G is substituted C 1-6 aliphatic hydrocarbon, wherein each of the methylene groups of the C 1-6 aliphatic hydrocarbon is optionally and independently substituted with J; J is -NH-, -S-, -O-, -C(=O)-, -C(=O)NH-, -SO-, -SO 2 -, -NHC(=O)-, -C(=O)O-, -SO 2 NH- or - NHC(=O)NH-; m is 0, 1, 2 or 3; and n is 0, 1, 2, 3 or 4; with the proviso that: when T is F, Cl, Br or CF 3, R 1 is OH; when T is H, is and Q is not phene; when T is NO 2, R 1 is not H. U is phenyl; each R 1 and R 2 is independently H, D, halogen, OH, NH 2, NO 2, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3-to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (=O), NH 2, NO 2 or CN; T is H, D, F, Cl, Br, NO 2, CN or CF 3; X is CR 4 or N; R 4 is H, D, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylamino or C 1-6 haloalkoxy; each of Y and Z is independently C, CH or N; " ----- " refers to a single bond or a double bond; Q is phene, C 4-7 carbocycle, 4- to 7-membered heterocycle or 5- to 6-membered heteroaromatic ring; each R 3 is independently H, D, halogen, oxo (=O), OH, NH 2, NO 2, CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3-to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, 5- to 10-membered heteroaryl, phenyl, naphthyl or G, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, C 1-6 haloalkylamino, 3- to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, or 5- to 10-membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (=O), NH 2, NO 2, CN or G; G is substituted C 1-6 aliphatic hydrocarbon, wherein each of the methylene groups of the C 1-6 aliphatic hydrocarbon is optionally and independently substituted with J; J is -NH-, -S-, -O-, -C(=O)-, -C(=O)NH-, -SO-, -SO 2 -, -NHC(=O)-, -C(=O)O-, -SO 2 NH- or - NHC(=O)NH-; m is 0, 1, 2 or 3; and n is 0, 1, 2, 3 or 4; with the proviso that: when T is F, Cl, Br or CF 3, R 1 is OH; when T is H, is and Q is not phene; when T is NO 2, R 1 is not H. when T is F, Cl, Br or CF 3, R 1 is OH; when T is H, is and Q is not phene; when T is NO 2, R 1 is not H.