A compound of formula la: or a pharmaceutically acceptable salt, deuterated analog, stereoisomer, or a mixture of stereoisomers thereof, wherein: R 1 is optionally substituted cycloalkyl or C 1-6 alkyl optionally substituted with halo; R 2 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkenyl, optionally substituted C 1-6 alkynyl, optionally substituted cycloalkyl, optionally substituted C 1-6 alkoxy, optionally substituted cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or -C N(R 11)(R 12); R 3 is optionally substituted C 1-6 alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, or -N(R 11)(R 12); R 4 is hydrogen or halo; R 6 and R 7 are each independently hydrogen or C 1-6 alkyl optionally substituted with halo; R 8 and R 9 are each independently hydrogen, cyano, halo, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkoxy, or optionally substituted heteroaryl; each R 10 is independently optionally substituted C 1-6 alkyl or optionally substituted C 1-6 alkoxy; and R 11 and R 12 are each independently hydrogen, optionally substituted C 1-6 alkyl, or optionally substituted cycloalkyl; wherein the optional substituent is selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, acyl, amido, amino, amidino, aryl, aralkyl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, cycloalkyl, cycloalkylalkyl, guanadino, halo, haloalkyl, haloalkoxy, hydroxyalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydrazine, hydrazone, imino, imido, hydroxy, oxo, oxime, nitro, sulfonyl, sulfinyl, alkylsulfonyl, alkylsulfinyl, thiocyanate, sulfinic acid, sulfonic acid, sulfonamido, thiol, thioxo, N-oxide, or -Si(R y) 3 wherein each Ry is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl. R 1 is optionally substituted cycloalkyl or C 1-6 alkyl optionally substituted with halo; R 2 is halo, cyano, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkenyl, optionally substituted C 1-6 alkynyl, optionally substituted cycloalkyl, optionally substituted C 1-6 alkoxy, optionally substituted cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, -C R 10, or -C N(R 11)(R 12); R 3 is optionally substituted C 1-6 alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkoxy, optionally substituted C 1-6 alkylthio, optionally substituted C 1-6 alkylsulfonyl, or -N(R 11)(R 12); R 4 is hydrogen or halo; R 6 and R 7 are each independently hydrogen or C 1-6 alkyl optionally substituted with halo; R 8 and R 9 are each independently hydrogen, cyano, halo, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkoxy, or optionally substituted heteroaryl; each R 10 is independently optionally substituted C 1-6 alkyl or optionally substituted C 1-6 alkoxy; and R 11 and R 12 are each independently hydrogen, optionally substituted C 1-6 alkyl, or optionally substituted cycloalkyl; wherein the optional substituent is selected from alkyl, alkenyl, alkynyl, alkoxy, alkylthio, acyl, amido, amino, amidino, aryl, aralkyl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, cycloalkyl, cycloalkylalkyl, guanadino, halo, haloalkyl, haloalkoxy, hydroxyalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, hydrazine, hydrazone, imino, imido, hydroxy, oxo, oxime, nitro, sulfonyl, sulfinyl, alkylsulfonyl, alkylsulfinyl, thiocyanate, sulfinic acid, sulfonic acid, sulfonamido, thiol, thioxo, N-oxide, or -Si(R y) 3 wherein each Ry is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl.