mhurhangee/ep-ind-claims huggingface dataset:
A kit or device for assessing a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration, said kit or device comprising: (i) a primer pair, wherein the primers hybridize in the DNA sequence between the 3' end of exon 22 of the complement factor H gene and the 5' end of exon 1 of the complement Factor H-related 4 (CFHR4) gene and at least one primer is immobilized on a substrate or is 15-30 bases in length; or (ii) a primer pair, wherein at least one primer hybridizes in the intergenic DNA sequence between the CFHR1 gene and the CFHR3 gene; or (iii) an anti-CFHR3 antibody and/or an anti-CFHR-1 antibody; or (iv) a nucleic acid probe, wherein the probe is labeled or immobilized and the probe hybridizes to a sequence in the region between the 3' end of exon 22 of the CFH gene and the 5' end of exon 1 of the CFHR4 gene; for detecting the presence or absence in chromosome 1 of the subject of a deletion of a region between the 3' end of exon 22 of the complement factor H gene and the 5' end of exon 1 of the complement Factor H-related 4 (CFHR4) gene in chromosome 1, wherein the deletion encompasses at least a portion of the complement Factor H-related 3 (CFHR3) gene and at least a portion of the Factor H-related 1 (CFHR1) gene, wherein the presence of the deletion in chromosome 1 indicates the subject is at increased risk of developing a vascular disorder and is at decreased risk of developing AMD. (i) a primer pair, wherein the primers hybridize in the DNA sequence between the 3' end of exon 22 of the complement factor H gene and the 5' end of exon 1 of the complement Factor H-related 4 (CFHR4) gene and at least one primer is immobilized on a substrate or is 15-30 bases in length; or (ii) a primer pair, wherein at least one primer hybridizes in the intergenic DNA sequence between the CFHR1 gene and the CFHR3 gene; or (iii) an anti-CFHR3 antibody and/or an anti-CFHR-1 antibody; or (iv) a nucleic acid probe, wherein the probe is labeled or immobilized and the probe hybridizes to a sequence in the region between the 3' end of exon 22 of the CFH gene and the 5' end of exon 1 of the CFHR4 gene;
A barcode image recognition method, comprising capturing at least one barcode to generate a preview image, the preview image having at least one barcode image of the at least one barcode; decoding the barcode image to obtain barcode information and a plurality of vertex coordinates (P1,P2,P3,P4) of the barcode image; caching the barcode information of the barcode image; forming a plurality of image boundaries (L1,L2,L3,L4) of the barcode image with the plurality of vertex coordinates (P1,P2,P3,P4) of the barcode image; generating a detection beeline from a specified point to a side edge of the preview image; determining the number of intersections of the plurality of image boundaries (L1,L2,L3,L4) of the barcode image and the detection beeline; identifying the barcode image with odd number of intersections from the at least one barcode image as a target image; and outputting (S80, S80')) the barcode information of the target image T). capturing at least one barcode to generate a preview image, the preview image having at least one barcode image of the at least one barcode; decoding the barcode image to obtain barcode information and a plurality of vertex coordinates (P1,P2,P3,P4) of the barcode image; caching the barcode information of the barcode image; forming a plurality of image boundaries (L1,L2,L3,L4) of the barcode image with the plurality of vertex coordinates (P1,P2,P3,P4) of the barcode image; generating a detection beeline from a specified point to a side edge of the preview image; determining the number of intersections of the plurality of image boundaries (L1,L2,L3,L4) of the barcode image and the detection beeline; identifying the barcode image with odd number of intersections from the at least one barcode image as a target image; and outputting (S80, S80')) the barcode information of the target image T).
An atherectomy catheter for use in a vessel comprising: an elongate catheter body; an annular cutter; an s-shaped curved portion in the elongate catheter body; and a nosecone configured to pivot away from the elongate body to expose the cutter, characterized in that: (i) the curved portion includes a frame having a longitudinal proximal spine connecting a first annular spine to a second annular spine, and a longitudinal distal spine connecting the second annular spine to a third annular spine, the longitudinal proximal spine positioned approximately 180 degrees away from the longitudinal distal spine, (ii) the frame has space that is open on a side opposite the longitudinal proximal spine between the first annular spine and the second annular spine, and the frame has space that is open on a side opposite the longitudinal distal spine between the second annular spine and the third annular spine, (iii) the third annular spine is a distal-most spine and includes a beveled distal edge, and (iv) the bevel is configured to provide space for the nosecone to pivot. an elongate catheter body; an annular cutter; an s-shaped curved portion in the elongate catheter body; and a nosecone configured to pivot away from the elongate body to expose the cutter, characterized in that: (i) the curved portion includes a frame having a longitudinal proximal spine connecting a first annular spine to a second annular spine, and a longitudinal distal spine connecting the second annular spine to a third annular spine, the longitudinal proximal spine positioned approximately 180 degrees away from the longitudinal distal spine, (ii) the frame has space that is open on a side opposite the longitudinal proximal spine between the first annular spine and the second annular spine, and the frame has space that is open on a side opposite the longitudinal distal spine between the second annular spine and the third annular spine, (iii) the third annular spine is a distal-most spine and includes a beveled distal edge, and (iv) the bevel is configured to provide space for the nosecone to pivot. (i) the curved portion includes a frame having a longitudinal proximal spine connecting a first annular spine to a second annular spine, and a longitudinal distal spine connecting the second annular spine to a third annular spine, the longitudinal proximal spine positioned approximately 180 degrees away from the longitudinal distal spine, (ii) the frame has space that is open on a side opposite the longitudinal proximal spine between the first annular spine and the second annular spine, and the frame has space that is open on a side opposite the longitudinal distal spine between the second annular spine and the third annular spine, (iii) the third annular spine is a distal-most spine and includes a beveled distal edge, and (iv) the bevel is configured to provide space for the nosecone to pivot.
Pressure control valve, comprising: a housing with an inlet opening and an outflow opening; a valve seat in the housing at the end of the inlet opening; a valve pin which is guided in the housing with an actuating element for closing the valve seat; a sealing element (42, 42') at one end of the actuating element, which sealing element (42, 42') is configured to be deposited in the valve seat upon movement of the valve pin, with the result that a fluid flow between the inlet opening and the outflow opening is interrupted; the actuating element being guided in a guide in the housing and having at least one side duct which is configured to conduct fluid from the inlet opening through the guide in the direction of the outflow opening, characterized in that the valve pin comprises an armature pin which is supported on the actuating element. a housing with an inlet opening and an outflow opening; a valve seat in the housing at the end of the inlet opening; a valve pin which is guided in the housing with an actuating element for closing the valve seat; a sealing element (42, 42') at one end of the actuating element, which sealing element (42, 42') is configured to be deposited in the valve seat upon movement of the valve pin, with the result that a fluid flow between the inlet opening and the outflow opening is interrupted; the actuating element being guided in a guide in the housing and having at least one side duct which is configured to conduct fluid from the inlet opening through the guide in the direction of the outflow opening, characterized in that the valve pin comprises an armature pin which is supported on the actuating element.
An operation method of an infrastructure supporting an automated valet parking service, the method comprising: initiating an automated valet parking procedure; providing a vehicle with a target position and a first guide route that guides the vehicle to the target position; detecting an unexpected incident based on situation information while the first guide route is provided to the vehicle; and providing the vehicle with a second guide route to deal with the unexpected incident, wherein the first guide route and the second guide route are provided using a plurality of lighting devices installed in a parking lot, and wherein a first lighting pattern of the first guide route and a second lighting pattern of the second guide route are different from each other. initiating an automated valet parking procedure; providing a vehicle with a target position and a first guide route that guides the vehicle to the target position; detecting an unexpected incident based on situation information while the first guide route is provided to the vehicle; and providing the vehicle with a second guide route to deal with the unexpected incident, wherein the first guide route and the second guide route are provided using a plurality of lighting devices installed in a parking lot, and wherein a first lighting pattern of the first guide route and a second lighting pattern of the second guide route are different from each other.
Dual clutch for coupling an engine-side input shaft to a first gearbox-side output shaft and/or a second gear-side output shaft, comprising: a first clutch which has a first contact pressure plate, which can move axially relative to a first counterplate and has a purpose of coupling a first clutch disk which is connected to the first output shaft, wherein a first contact pressure plate friction area, pointing towards the first counterplate, of the first clutch covers a first friction area of the first contact pressure plate, a second clutch which has a second contact pressure plate which can move axially relative to a second counterplate and has the purpose of coupling a second clutch disk which is connected to the second output shaft, wherein a second contact-pressure plate friction area which points towards the second counterplate, of the second clutch covers a second friction area of the second contact-pressure plate, a first spring element which is connected to the first contact-pressure plate, for axially moving the first contact-pressure plate into a first initial position, and a second spring element, connected to the second contact-pressure plate, for axially moving the second contact-pressure plate into a second initial position, wherein the first spring element is arranged at least partially, preferably completely, radially within a radially outer edge of the first friction area, characterized in that the first spring element is connected directly to the second counterplate. a first clutch which has a first contact pressure plate, which can move axially relative to a first counterplate and has a purpose of coupling a first clutch disk which is connected to the first output shaft, wherein a first contact pressure plate friction area, pointing towards the first counterplate, of the first clutch covers a first friction area of the first contact pressure plate, a second clutch which has a second contact pressure plate which can move axially relative to a second counterplate and has the purpose of coupling a second clutch disk which is connected to the second output shaft, wherein a second contact-pressure plate friction area which points towards the second counterplate, of the second clutch covers a second friction area of the second contact-pressure plate, a first spring element which is connected to the first contact-pressure plate, for axially moving the first contact-pressure plate into a first initial position, and a second spring element, connected to the second contact-pressure plate, for axially moving the second contact-pressure plate into a second initial position, wherein the first spring element is arranged at least partially, preferably completely, radially within a radially outer edge of the first friction area,
A method of preparing a stable liquid pharmaceutical formulation, comprising combining: (a) an antibody which binds specifically to human programmed death-1 (PD-1),wherein the antibody comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained in a heavy chain variable region (HCVR) and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained in a light chain variable region (LCVR), wherein HCDR1 comprises SEQ ID NO: 3, HCDR2 comprises SEQ ID NO: 4, HCDR3 comprises SEQ ID NO: 5, LCDR1 comprises SEQ ID NO: 6, LCDR2 comprises SEQ ID NO: 7, and LCDR3 comprises SEQ ID NO: 8; (b) a buffer comprising histidine; (c) an organic solvent comprising polysorbate; (d) sucrose as stabilizer; and (e) proline as viscosity modifier; wherein the stable liquid pharmaceutical formulation has a pH of 6.0 ± 0.3. (a) an antibody which binds specifically to human programmed death-1 (PD-1),wherein the antibody comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained in a heavy chain variable region (HCVR) and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained in a light chain variable region (LCVR), wherein HCDR1 comprises SEQ ID NO: 3, HCDR2 comprises SEQ ID NO: 4, HCDR3 comprises SEQ ID NO: 5, LCDR1 comprises SEQ ID NO: 6, LCDR2 comprises SEQ ID NO: 7, and LCDR3 comprises SEQ ID NO: 8; (b) a buffer comprising histidine; (c) an organic solvent comprising polysorbate; (d) sucrose as stabilizer; and (e) proline as viscosity modifier;
A process for realizing wear-resistant panels usable for the formation of anti-wear surfaces, comprising the following steps: - forming a matrix having a support function and which is provided, on a work surface, with a plurality of cavities, which are dimensioned and shaped to accommodate wear-resistant inserts of matching size, and are distributed over said work surface according to a pre-established order and geometrical arrangement; - spreading adhesive, if necessary; - inserting the inserts in the cavities; - curing, if necessary; the cavities being shaped and dimensioned in relation to the shape and size of the inserts so that, when insertion and coupling are completed, the inserts are firmly anchored to the respective cavities; each of the cavities having an insertion mouth and a coupling surface comprising a concave part, the concave part of the coupling surface situated in proximity to the insertion mouth being configured with ridges or ribs whose function is to achieve the centring of the respective inserts, as well as favouring a pre-established distribution of adhesive in the coupling zone. - forming a matrix having a support function and which is provided, on a work surface, with a plurality of cavities, which are dimensioned and shaped to accommodate wear-resistant inserts of matching size, and are distributed over said work surface according to a pre-established order and geometrical arrangement; - spreading adhesive, if necessary; - inserting the inserts in the cavities; - curing, if necessary;
A display system, comprising: an imager configured to generate imaging light using a variable spectrum across a field of view of an input pupil; a substrate of optical material that includes a waveguide; an in-coupling diffractive optical element (440,1105) disposed on the substrate, the in-coupling diffractive optical element (440,1105) having an input surface configured to receive incident imaging light over the input pupil; and an out-coupling diffractive optical element (410,1115) disposed on the substrate, the out-coupling diffractive optical element (410, 1115) having an output surface and configured for pupil expansion of the imaging light in one direction, and further configured to out-couple, as an output display from the output surface, the imaging light with expanded exit pupil relative to the input pupil, wherein the in-coupling diffractive optical element (440,1105) is configured to spread the spectrum of imaging light over the input pupil field of view so that at least a different part of the spectrum propagates in total internal reflection in the waveguide for each portion of the field of view, wherein the imager includes an illumination unit which is configured to compensate so that the spectrum shifts slightly over the entire field of view so that only the part of the spectrum that can propagate within the waveguide at each angle of the field of view is used for that part of the field of view. an imager configured to generate imaging light using a variable spectrum across a field of view of an input pupil; a substrate of optical material that includes a waveguide; an in-coupling diffractive optical element (440,1105) disposed on the substrate, the in-coupling diffractive optical element (440,1105) having an input surface configured to receive incident imaging light over the input pupil; and an out-coupling diffractive optical element (410,1115) disposed on the substrate, the out-coupling diffractive optical element (410, 1115) having an output surface and configured for pupil expansion of the imaging light in one direction, and further configured to out-couple, as an output display from the output surface, the imaging light with expanded exit pupil relative to the input pupil,
A method of assembling a fluid dispenser device, the method being characterized in that it comprises the hollowing steps: · pre-assembling a first unit comprising a body and a lateral actuator system, said lateral actuator system including a presser element that is mounted on the body to pivot about an axis, an actuator element being mounted on said presser element to pivot about an axis, said presser element having a pre-assembled position in which said lateral actuator system is blocked; · assembling in said first pre-assembled unit a second unit comprising a dispenser member, such as a pump or a valve, that is mounted on a reservoir by means of a fastener ring, said dispenser member comprising a central axis, and · moving said presser element from its pre-assembled position to a final assembled position that is axially offset from said pre-assembled position along said central axis, and in which said actuator element co-operates operationally with said fastener ring so as to actuate said dispenser member each time the lateral actuator system is actuated. · pre-assembling a first unit comprising a body and a lateral actuator system, said lateral actuator system including a presser element that is mounted on the body to pivot about an axis, an actuator element being mounted on said presser element to pivot about an axis, said presser element having a pre-assembled position in which said lateral actuator system is blocked; · assembling in said first pre-assembled unit a second unit comprising a dispenser member, such as a pump or a valve, that is mounted on a reservoir by means of a fastener ring, said dispenser member comprising a central axis, and · moving said presser element from its pre-assembled position to a final assembled position that is axially offset from said pre-assembled position along said central axis, and in which said actuator element co-operates operationally with said fastener ring so as to actuate said dispenser member each time the lateral actuator system is actuated.
A cyclic compound having a molecular weight of 500 to 5000 and represented by the formula: wherein R 1 are each independently (meth)acryloyl group, a hydrogen atom, a cyano group, a nitro group, a substituted or non-substituted heterocyclic group, a halogen atom, a substituted or non-substituted linear aliphatic hydrocarbon group having 1 to 20 carbon atoms, a substituted or non-substituted branched aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted cyclic aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted aryl group having 6 to 20 carbon atoms, a substituted or non-substituted alkylsilyl group having 1 to 20 carbon atoms, or a substituted or non-substituted alkenyl group having 2 to 20 carbon atoms; R 4 are each independently a cyano group, a nitro group, a substituted or non-substituted heterocyclic group, a halogen atom, a substituted or non-substituted linear aliphatic hydrocarbon group having 1 to 20 carbon atoms, a substituted or non-substituted branched aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted cyclic aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted aryl group having 6 to 20 carbon atoms, a substituted or non-substituted alkoxy group having 1 to 20 carbon atoms, or a substituted or non-substituted alkylsilyl group having 1 to 20 carbon atoms; p is an integer of 0 to 5; and at least one of R 1 is a (meth)acryloyl group. wherein R 1 are each independently (meth)acryloyl group, a hydrogen atom, a cyano group, a nitro group, a substituted or non-substituted heterocyclic group, a halogen atom, a substituted or non-substituted linear aliphatic hydrocarbon group having 1 to 20 carbon atoms, a substituted or non-substituted branched aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted cyclic aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted aryl group having 6 to 20 carbon atoms, a substituted or non-substituted alkylsilyl group having 1 to 20 carbon atoms, or a substituted or non-substituted alkenyl group having 2 to 20 carbon atoms; R 4 are each independently a cyano group, a nitro group, a substituted or non-substituted heterocyclic group, a halogen atom, a substituted or non-substituted linear aliphatic hydrocarbon group having 1 to 20 carbon atoms, a substituted or non-substituted branched aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted cyclic aliphatic hydrocarbon group having 3 to 20 carbon atoms, a substituted or non-substituted aryl group having 6 to 20 carbon atoms, a substituted or non-substituted alkoxy group having 1 to 20 carbon atoms, or a substituted or non-substituted alkylsilyl group having 1 to 20 carbon atoms; p is an integer of 0 to 5; and at least one of R 1 is a (meth)acryloyl group.