A compound selected from Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 is 4-phenol; R 2 is selected from -CN, -OCH3, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, and cyclopropyl; R 3 is selected from F, Cl, Br, I, -CN, -CH 3, -CH 2 CH 3, -CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH, -CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F, -CHF 2, -CH 2 NH 2, -CH 2 NHSO 2 CH 3,-CH 2 NHCH 3, -CH 2 N(CH 3) 2, -CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN,-CH 2 CN, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2,-CONHCH 3, -CONHCH 2 CH 3, -CONHCH(CH 3) 2, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3, -OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OP 2, -S 2 N(CH 3) 2,-SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, cyclopropylamide, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, and morpholino; n is selected from 0, 1, 2, and 3; and R 4 is selected from H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, cyclopropyl, and cyclopropylmethyl; where aryl, carbocyclyl, heterocyclyl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CH3, -CH 2 CH 3,-CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH,-CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F,-CRF 2, -CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN, -CH 2 CN, -CH 2 NH 2,-CH 2 NHSO 2 CH 3, -CH 2 NHCH 3, -CH 2 N(CH 3) 2, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3, -OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OP 2, -S 2 N(CH 3) 2,-SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, cyclopropylamide, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, and morpholino. R 1 is 4-phenol; R 2 is selected from -CN, -OCH3, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, and cyclopropyl; R 3 is selected from F, Cl, Br, I, -CN, -CH 3, -CH 2 CH 3, -CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH, -CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F, -CHF 2, -CH 2 NH 2, -CH 2 NHSO 2 CH 3,-CH 2 NHCH 3, -CH 2 N(CH 3) 2, -CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN,-CH 2 CN, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2,-CONHCH 3, -CONHCH 2 CH 3, -CONHCH(CH 3) 2, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3, -OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OP 2, -S 2 N(CH 3) 2,-SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, cyclopropylamide, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, and morpholino; n is selected from 0, 1, 2, and 3; and R 4 is selected from H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, cyclopropyl, and cyclopropylmethyl; where aryl, carbocyclyl, heterocyclyl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CH3, -CH 2 CH 3,-CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 OCH 3, -CH 2 CH 2 OH, -C(CH 3) 2 OH,-CH CH(CH 3) 2, -C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CH 2 OP 2, -CH 2 F,-CRF 2, -CF 3, -CH 2 CF 3, -CH 2 CHF 2, -CH(CH 3)CN, -C(CH 3) 2 CN, -CH 2 CN, -CH 2 NH 2,-CH 2 NHSO 2 CH 3, -CH 2 NHCH 3, -CH 2 N(CH 3) 2, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3, -COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, -NO 2, =O, -OH, -OCH 3, -OCH 2 CH 3, -OCH 2 CH 2 OCH 3, -OCH 2 CH 2 OH, -OCH 2 CH 2 N(CH 3) 2, -OP 2, -S 2 N(CH 3) 2,-SCH 3, -S 2 CH 3, -S 3 H, cyclopropyl, cyclopropylamide, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, and morpholino.