An outpatient ambulatory patient worn apparatus for managing chronic lung disease comprising: a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data, said plurality of sensors including at least an oximeter, a respiratory rate sensor, and at least one activity or motion sensor, wherein said at least one oximeter, said respiratory rate sensor and said at least one activity or motion sensor are continuously operative to measure said plurality of physiological data in an outpatient setting during activities of daily living comprising rest, exertion, and sleep; a central monitoring unit CMU communicatively coupled to said plurality of sensors and to an interface device, said CMU comprising a computer, and said CMU to be worn by the patient in an outpatient setting during activities of daily living, said CMU programmed to record concurrently a set of time stamped primary data comprising measurement data from each of said plurality of sensors to a non-volatile memory at a predetermined interval for one or more epochs of time, and to categorize, at an acquisition rate or some multiple of the acquisition rate, each recorded measurement of each of said plurality of sensors stored in said set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, said predominate activity type selected from a plurality of activity types including rest, exertion and sleep; and a generate report process running on said CMU to provide at least one or more reports in real time including at least an indication or determination of whether a chronic lung disease treatment is needed by the patient based on said set of activity type stamped data. a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data, said plurality of sensors including at least an oximeter, a respiratory rate sensor, and at least one activity or motion sensor, wherein said at least one oximeter, said respiratory rate sensor and said at least one activity or motion sensor are continuously operative to measure said plurality of physiological data in an outpatient setting during activities of daily living comprising rest, exertion, and sleep; a central monitoring unit CMU communicatively coupled to said plurality of sensors and to an interface device, said CMU comprising a computer, and said CMU to be worn by the patient in an outpatient setting during activities of daily living, said CMU programmed to record concurrently a set of time stamped primary data comprising measurement data from each of said plurality of sensors to a non-volatile memory at a predetermined interval for one or more epochs of time, and to categorize, at an acquisition rate or some multiple of the acquisition rate, each recorded measurement of each of said plurality of sensors stored in said set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, said predominate activity type selected from a plurality of activity types including rest, exertion and sleep; and a generate report process running on said CMU to provide at least one or more reports in real time including at least an indication or determination of whether a chronic lung disease treatment is needed by the patient based on said set of activity type stamped data.