A pressure support system configured to adjust one or more parameters of a pressurized flow of breathable gas delivered to a subject, the pressure support system comprising: a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject; a humidifier configured to humidify the pressurized flow of breathable gas; one or more sensors configured to generate output signals conveying information related to one or more parameters of the pressurized flow of breathable gas; a user interface configured to receive entry and/or selection of feedback information from the subject indicating a comfort level with the pressurized flow of breathable gas; and one or more physical computer processors configured by computer readable instructions to: control the pressure generator and the humidifier to deliver the pressurized flow of breathable gas to the subject according to a predetermined therapy regime based on the output signals; receive feedback information entered and/or selected through the user interface; and make an automatic adjustment to the pressurized flow of breathable gas to enhance the comfort level of the subject, the automatic adjustment based on the received feedback information and the output signals, the automatic adjustment including adjustment of one or more of the pressure generator or the humidifier; characterized in that the one or more physical computer processors are further configured by computer readable instructions to: receive additional feedback information entered and/or selected through the user interface subsequent to the automatic adjustment; and prompt the subject to manually adjust one or more of the pressure generator, the humidifier, or the ambient environment based on the additional feedback information. a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject; a humidifier configured to humidify the pressurized flow of breathable gas; one or more sensors configured to generate output signals conveying information related to one or more parameters of the pressurized flow of breathable gas; a user interface configured to receive entry and/or selection of feedback information from the subject indicating a comfort level with the pressurized flow of breathable gas; and one or more physical computer processors configured by computer readable instructions to: control the pressure generator and the humidifier to deliver the pressurized flow of breathable gas to the subject according to a predetermined therapy regime based on the output signals; receive feedback information entered and/or selected through the user interface; and make an automatic adjustment to the pressurized flow of breathable gas to enhance the comfort level of the subject, the automatic adjustment based on the received feedback information and the output signals, the automatic adjustment including adjustment of one or more of the pressure generator or the humidifier; characterized in that the one or more physical computer processors are further configured by computer readable instructions to: receive additional feedback information entered and/or selected through the user interface subsequent to the automatic adjustment; and prompt the subject to manually adjust one or more of the pressure generator, the humidifier, or the ambient environment based on the additional feedback information. control the pressure generator and the humidifier to deliver the pressurized flow of breathable gas to the subject according to a predetermined therapy regime based on the output signals; receive feedback information entered and/or selected through the user interface; and make an automatic adjustment to the pressurized flow of breathable gas to enhance the comfort level of the subject, the automatic adjustment based on the received feedback information and the output signals, the automatic adjustment including adjustment of one or more of the pressure generator or the humidifier; receive additional feedback information entered and/or selected through the user interface subsequent to the automatic adjustment; and prompt the subject to manually adjust one or more of the pressure generator, the humidifier, or the ambient environment based on the additional feedback information.