An alignment system for aligning a first member in fluid flow connection with a second member, the alignment system comprising: a receptacle structure provided on the first member and having an interior chamber and an opening into the interior chamber, a connection portion provided on the second member, the connection portion having an interior chamber and an opening into the interior chamber of the connection portion, the connection portion having a size and shape suitable to be received at least partially into the opening of the receptacle structure as the first member and the second member are moved relative to each other, a groove provided in the receptacle structure; a protrusion arranged on the connection portion to be insertable into the groove of the receptacle structure as the opening of the receptacle structure receives the connection portion; a needle supported within the interior chamber of the receptacle structure, the needle being arranged to extend out of the receptacle structure a first distance, the needle further having a piercing end; and a septum supported by the connection portion of the second member in a position to cover the opening of the connection portion; a pierceable member provided within the interior chamber, adjacent the opening of the receptacle structure, the pierceable member surrounding the end of the needle, wherein a second distance that the portion of the protrusion extends from the connection portion is greater than the first distance that the needle extends out of the receptacle structure and is greater than a third distance that the pierceable member extends out of the receptacle structure; wherein, upon moving the first member and the second member together, the protrusion is received into the groove and the connection portion is received into the opening of the receptacle structure to cause the piercing end of the needle to pierce the septum to come into fluid flow communication with the interior chamber of the connection portion; the protrusion being arranged on the connection portion such that the portion of the protrusion is insertable into the groove of the receptacle structure before the connection portion receives a portion of the pierceable member. a receptacle structure provided on the first member and having an interior chamber and an opening into the interior chamber, a connection portion provided on the second member, the connection portion having an interior chamber and an opening into the interior chamber of the connection portion, the connection portion having a size and shape suitable to be received at least partially into the opening of the receptacle structure as the first member and the second member are moved relative to each other, a groove provided in the receptacle structure; a protrusion arranged on the connection portion to be insertable into the groove of the receptacle structure as the opening of the receptacle structure receives the connection portion; a needle supported within the interior chamber of the receptacle structure, the needle being arranged to extend out of the receptacle structure a first distance, the needle further having a piercing end; and a septum supported by the connection portion of the second member in a position to cover the opening of the connection portion; a pierceable member provided within the interior chamber, adjacent the opening of the receptacle structure, the pierceable member surrounding the end of the needle, wherein a second distance that the portion of the protrusion extends from the connection portion is greater than the first distance that the needle extends out of the receptacle structure and is greater than a third distance that the pierceable member extends out of the receptacle structure; wherein, upon moving the first member and the second member together, the protrusion is received into the groove and the connection portion is received into the opening of the receptacle structure to cause the piercing end of the needle to pierce the septum to come into fluid flow communication with the interior chamber of the connection portion; the protrusion being arranged on the connection portion such that the portion of the protrusion is insertable into the groove of the receptacle structure before the connection portion receives a portion of the pierceable member.