A therapeutic coferon dimer inhibitor comprising: (i) a first coferon monomer having a molecular weight of less than 1000 daltons and comprising: a phenylboronic acid linker element having a molecular weight of 45 to 450 daltons; a first diversity element connected to the phenylboronic acid linker element; and (ii) a second coferon monomer having a molecular weight of less than 1000 daltons and comprising: a 1,2 diol binding partner linker element having a molecular weight of 45 to 450 daltons and a second diversity element connected to the 1,2 diol binding partner linker element, wherein each of the first and second diversity elements are ligands that are known to bind to orthogonal sites on an intracellular protein target and have a dissociation constant less than 300 μM, and when the first coferon monomer, the second coferon monomer, and the target are in proximity to one another, the following weak binding interactions occur simultaneously to produce specific binding between the first and second coferon monomers and the target: the phenylboronic acid linker element binds to the 1,2 diol binding partner linker element to form a boronate ester, the first diversity element binds to the target, and the second diversity element binds to the target. (i) a first coferon monomer having a molecular weight of less than 1000 daltons and comprising: a phenylboronic acid linker element having a molecular weight of 45 to 450 daltons; a first diversity element connected to the phenylboronic acid linker element; and a phenylboronic acid linker element having a molecular weight of 45 to 450 daltons; a first diversity element connected to the phenylboronic acid linker element; and (ii) a second coferon monomer having a molecular weight of less than 1000 daltons and comprising: a 1,2 diol binding partner linker element having a molecular weight of 45 to 450 daltons and a second diversity element connected to the 1,2 diol binding partner linker element, wherein each of the first and second diversity elements are ligands that are known to bind to orthogonal sites on an intracellular protein target and have a dissociation constant less than 300 μM, and when the first coferon monomer, the second coferon monomer, and the target are in proximity to one another, the following weak binding interactions occur simultaneously to produce specific binding between the first and second coferon monomers and the target: the phenylboronic acid linker element binds to the 1,2 diol binding partner linker element to form a boronate ester, the first diversity element binds to the target, and the second diversity element binds to the target. a 1,2 diol binding partner linker element having a molecular weight of 45 to 450 daltons and a second diversity element connected to the 1,2 diol binding partner linker element, wherein each of the first and second diversity elements are ligands that are known to bind to orthogonal sites on an intracellular protein target and have a dissociation constant less than 300 μM, and when the first coferon monomer, the second coferon monomer, and the target are in proximity to one another, the following weak binding interactions occur simultaneously to produce specific binding between the first and second coferon monomers and the target: the phenylboronic acid linker element binds to the 1,2 diol binding partner linker element to form a boronate ester, the first diversity element binds to the target, and the second diversity element binds to the target.