A minimally invasive surgical suture end locking device for clamping and securing the end of a suture by means of a locking pin, comprising: a hooking assembly, a clamping structure, a power rod, a locking pin, and an external conduit; wherein the hooking assembly comprises a closed flexible annular structure and a force application end leading out relative to the annular structure, wherein the annular structure is configured to lead out from a through area of the locking pin with a lead-out portion forming a closed area, and wherein the force application end is configured to drive the suture entering the closed area partially through the through area by pulling the annular structure under the action of an external force in the human body; wherein the clamping structure is configured to press the locking pin so that the locking pin deforms and clamps the suture, and wherein the power rod is provided with a pressing portion to press the clamping structure by linear motion so that the clamping structure moves and completes the pressing action; and wherein the clamping structure and the power rod are disposed in the external conduit, wherein the locking pin is configured to be inserted from an end of the external conduit and the depth of insertion is limited by a stop structure provided on the locking pin, and wherein the external conduit is provided with a through hole through which a portion of the suture passing through the through area is led out by the pulling of the annular structure, the through hole being provided on the side corresponding to a contact position where the clamping structure and the power rod contact each other at a set distance from the contact position, wherein the external conduit comprises a guide seat mounted at an end thereof, wherein the guide seat is configured to limit the insertion depth of the locking pin and guide the movement of the clamping structure, and characterized in that the guide seat is provided with a guide groove, and the clamping structure is provided with a protruding portion moving along the guide groove. wherein the hooking assembly comprises a closed flexible annular structure and a force application end leading out relative to the annular structure, wherein the annular structure is configured to lead out from a through area of the locking pin with a lead-out portion forming a closed area, and wherein the force application end is configured to drive the suture entering the closed area partially through the through area by pulling the annular structure under the action of an external force in the human body; wherein the clamping structure is configured to press the locking pin so that the locking pin deforms and clamps the suture, and wherein the power rod is provided with a pressing portion to press the clamping structure by linear motion so that the clamping structure moves and completes the pressing action; and wherein the clamping structure and the power rod are disposed in the external conduit, wherein the locking pin is configured to be inserted from an end of the external conduit and the depth of insertion is limited by a stop structure provided on the locking pin, and wherein the external conduit is provided with a through hole through which a portion of the suture passing through the through area is led out by the pulling of the annular structure, the through hole being provided on the side corresponding to a contact position where the clamping structure and the power rod contact each other at a set distance from the contact position, wherein the external conduit comprises a guide seat mounted at an end thereof, wherein the guide seat is configured to limit the insertion depth of the locking pin and guide the movement of the clamping structure, and characterized in that the guide seat is provided with a guide groove, and the clamping structure is provided with a protruding portion moving along the guide groove.