An electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device comprising: a housing having an axis extending therethrough, the housing further defining a cavity; a nozzle at least partially positioned within the housing, wherein the nozzle includes a nozzle tip configured to deliver a jet injection of the agent; wherein the cavity is sized to receive at least a portion of the agent cartridge therein, and wherein the nozzle is in fluid communication with the volume of the agent cartridge when the agent cartridge is positioned within the cavity; an array having a plurality of electrodes extending therefrom; a propulsion cartridge configured to operatively engage the agent cartridge when the agent cartridge is positioned within the cavity, to expel at least a portion of the pre-measured dose of agent through the nozzle; and a power supply in electrical communication with the array for sending a current to the plurality of electrodes for electroporating tissue of a subject, characterized in that the array is mounted to a support slide that is axially moveable with respect to the housing and the nozzle between a retracted position, where the electrodes are positioned inside the housing, and an extended position, where at least a portion of the electrodes are positioned outside the housing, the propulsion cartridge includes a propulsion rod positioned at least partially within the housing and movable between an armed position and a deployed position with respect to the housing, and wherein the propulsion rod is biased toward the deployed position, the electroporation device further comprises a trigger assembly, and wherein the trigger assembly is adjustable between a first position, where the propulsion rod is fixed in the armed position, and a second position, where the propulsion rod is adjustable between the armed and deployed positions, and the array is not in electrical communication with the power supply when the trigger assembly is in the first position, and the array is in electrical communication with the power supply when the trigger assembly is in the second position. a housing having an axis extending therethrough, the housing further defining a cavity; a nozzle at least partially positioned within the housing, wherein the nozzle includes a nozzle tip configured to deliver a jet injection of the agent; wherein the cavity is sized to receive at least a portion of the agent cartridge therein, and wherein the nozzle is in fluid communication with the volume of the agent cartridge when the agent cartridge is positioned within the cavity; an array having a plurality of electrodes extending therefrom; a propulsion cartridge configured to operatively engage the agent cartridge when the agent cartridge is positioned within the cavity, to expel at least a portion of the pre-measured dose of agent through the nozzle; and a power supply in electrical communication with the array for sending a current to the plurality of electrodes for electroporating tissue of a subject, characterized in that the array is mounted to a support slide that is axially moveable with respect to the housing and the nozzle between a retracted position, where the electrodes are positioned inside the housing, and an extended position, where at least a portion of the electrodes are positioned outside the housing, the propulsion cartridge includes a propulsion rod positioned at least partially within the housing and movable between an armed position and a deployed position with respect to the housing, and wherein the propulsion rod is biased toward the deployed position, the electroporation device further comprises a trigger assembly, and wherein the trigger assembly is adjustable between a first position, where the propulsion rod is fixed in the armed position, and a second position, where the propulsion rod is adjustable between the armed and deployed positions, and the array is not in electrical communication with the power supply when the trigger assembly is in the first position, and the array is in electrical communication with the power supply when the trigger assembly is in the second position.