A skin-treatment delivery device (200; 300; 400; 500; 700), comprising: a hand-held housing (210; 310; 410) including one or more treatment agent reservoirs, each of the one or more treatment agent reservoirs including at least one port with a controllable valve; at least one conduit in fluid communication with the at least one port with the controllable valve and an opening defined by a surface of the hand-held housing; a data storage component configured to store information associated with a microbe profile, the microbe profile including a two-dimensional spatial distribution of one or more types of microbes at each of one or more locations on a skin surface of an individual; a location-capture component (270; 1010; 1330; 1410) including circuitry to measure a feature of a location on the skin surface of the individual; and a computing component including a processor, the computing component operably coupled to the controllable valve of each of the one or more treatment agent reservoirs, the data storage component, and the location-capture component, the computing component including circuitry to receive information associated with the measured feature of the location on the skin surface of the individual from the location-capture component; correlate the received information associated with the measured feature of the location on the skin surface of the individual with the stored information associated with the microbe profile to determine a presence of at least one of the one or more types of microbes at said location; select one or more treatment agents for application to the location on the skin surface of the individual from a database of treatment agents based on the presence of the at least one of the one or more types of microbes at said location; and actuate the controllable valve of at least one of the one or more treatment agent reservoirs to modulate release of the selected one or more treatment agents onto said location on the skin surface of the individual. one or more treatment agent reservoirs, each of the one or more treatment agent reservoirs including at least one port with a controllable valve; at least one conduit in fluid communication with the at least one port with the controllable valve and an opening defined by a surface of the hand-held housing; a data storage component configured to store information associated with a microbe profile, the microbe profile including a two-dimensional spatial distribution of one or more types of microbes at each of one or more locations on a skin surface of an individual; a location-capture component (270; 1010; 1330; 1410) including circuitry to measure a feature of a location on the skin surface of the individual; and a computing component including a processor, the computing component operably coupled to the controllable valve of each of the one or more treatment agent reservoirs, the data storage component, and the location-capture component, the computing component including circuitry to receive information associated with the measured feature of the location on the skin surface of the individual from the location-capture component; correlate the received information associated with the measured feature of the location on the skin surface of the individual with the stored information associated with the microbe profile to determine a presence of at least one of the one or more types of microbes at said location; select one or more treatment agents for application to the location on the skin surface of the individual from a database of treatment agents based on the presence of the at least one of the one or more types of microbes at said location; and actuate the controllable valve of at least one of the one or more treatment agent reservoirs to modulate release of the selected one or more treatment agents onto said location on the skin surface of the individual. receive information associated with the measured feature of the location on the skin surface of the individual from the location-capture component; correlate the received information associated with the measured feature of the location on the skin surface of the individual with the stored information associated with the microbe profile to determine a presence of at least one of the one or more types of microbes at said location; select one or more treatment agents for application to the location on the skin surface of the individual from a database of treatment agents based on the presence of the at least one of the one or more types of microbes at said location; and actuate the controllable valve of at least one of the one or more treatment agent reservoirs to modulate release of the selected one or more treatment agents onto said location on the skin surface of the individual.