A compound represented by formula, a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein, D 1 is selected from -O- and -N(R 6)-; R 1 is selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R a; R 2 is selected from H, F, Cl, Br, I, OH, NH 2 and C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 R b; R 3 is selected from H, F, Cl, Br, I and C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 R c; or, R 2 and R 3 are attached together to form a ring, the ring is selected from C 3-7 cycloalkyl and 4-7 membered heterocycloalkyl, the C 3-7 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by 1, 2 or 3 R d; R 4 is selected from OH, NH 2, C 1-3 alkyl and C 1-3 alkylamino, wherein the C 1-3 alkyl and C 1-3 alkylamino are optionally substituted by 1, 2 or 3 R e; each of R 51, R 52, R 53, R 54 and R 55 is independently selected from H, F, Cl, Br, I, OH, NH 2, C 1-6 alkyl, C 1-6 alkylamino and C 1-6 alkoxy, wherein the C 1-6 alkyl, C 1-6 alkylamino and C 1-6 alkoxy are optionally substituted by 1, 2 or 3 R f; R 6 is selected from H, C 1-6 alkyl, C 1-6 alkyl-C(=O)-, C 1-6 alkyl-S(=O)-, C 1-6 alkylS(=O) 2 - and C 1-6 alkyl-O-C(=O)-, wherein the C 1-6 alkyl, C 1-6 alkyl-C(=O)-, C 1-6 alkylS(=O)-, C 1-6 alkyl-S(=O) 2 - and C 1-6 alkyl-O-C(=O)- are optionally substituted by R g; each of R a, R b, R c, R d, R e, R f and R g are independently selected from F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R; each R is independently selected from F, Cl, Br, I, OH and NH 2; the 4-7 membered heterocycloalkyl contains 1, 2, 3 or 4 heteroatoms or heteroatomic groups independently selected from -NH-, -O-, -S- and N; the carbon atom labeled with "*" is a chiral carbon atom, and exists in the form of or single enantiomer or enriched in one enantiomer. D 1 is selected from -O- and -N(R 6)-; R 1 is selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R a; R 2 is selected from H, F, Cl, Br, I, OH, NH 2 and C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 R b; R 3 is selected from H, F, Cl, Br, I and C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 R c; or, R 2 and R 3 are attached together to form a ring, the ring is selected from C 3-7 cycloalkyl and 4-7 membered heterocycloalkyl, the C 3-7 cycloalkyl and 4-7 membered heterocycloalkyl are optionally substituted by 1, 2 or 3 R d; R 4 is selected from OH, NH 2, C 1-3 alkyl and C 1-3 alkylamino, wherein the C 1-3 alkyl and C 1-3 alkylamino are optionally substituted by 1, 2 or 3 R e; each of R 51, R 52, R 53, R 54 and R 55 is independently selected from H, F, Cl, Br, I, OH, NH 2, C 1-6 alkyl, C 1-6 alkylamino and C 1-6 alkoxy, wherein the C 1-6 alkyl, C 1-6 alkylamino and C 1-6 alkoxy are optionally substituted by 1, 2 or 3 R f; R 6 is selected from H, C 1-6 alkyl, C 1-6 alkyl-C(=O)-, C 1-6 alkyl-S(=O)-, C 1-6 alkylS(=O) 2 - and C 1-6 alkyl-O-C(=O)-, wherein the C 1-6 alkyl, C 1-6 alkyl-C(=O)-, C 1-6 alkylS(=O)-, C 1-6 alkyl-S(=O) 2 - and C 1-6 alkyl-O-C(=O)- are optionally substituted by R g; each of R a, R b, R c, R d, R e, R f and R g are independently selected from F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R; each R is independently selected from F, Cl, Br, I, OH and NH 2; the 4-7 membered heterocycloalkyl contains 1, 2, 3 or 4 heteroatoms or heteroatomic groups independently selected from -NH-, -O-, -S- and N; the carbon atom labeled with "*" is a chiral carbon atom, and exists in the form of or single enantiomer or enriched in one enantiomer.