A glucose measurement system comprising: a biosensor having a plurality of electrodes including at least two electrodes (64; 66) with a reagent disposed thereon; and a meter including: a microcontroller coupled to a power source, memory and the plurality of electrodes of the biosensor (64; 66) and in which the microcontroller is configured to: drive a signal to the at least two electrodes when a fluid sample comprising glucose is deposited proximate the at least two electrodes to start a test measurement sequence for an electrochemical reaction of the glucose in the fluid sample with the reagent; measure an output signal from at least one electrode during the electrochemical reaction over a series of time intervals to obtain a magnitude of the output signal for each time interval; determine an output differential (ΔI) as a difference in the respective magnitudes of the output signal for at least two consecutive time intervals within a predetermined time window during the test measurement sequence; if the output differential (ΔI) is greater than a predetermined threshold (b) then increment an index value (x) as equal to the sum of both a previous value of the index (x) and the output differential (ΔI) and if the index (x) is greater or equal to a predetermined index value (a) then annunciate an error, otherwise calculate the glucose value from the output signal and annunciate the glucose value. a biosensor having a plurality of electrodes including at least two electrodes (64; 66) with a reagent disposed thereon; and a meter including: a microcontroller coupled to a power source, memory and the plurality of electrodes of the biosensor (64; 66) and in which the microcontroller is configured to: drive a signal to the at least two electrodes when a fluid sample comprising glucose is deposited proximate the at least two electrodes to start a test measurement sequence for an electrochemical reaction of the glucose in the fluid sample with the reagent; measure an output signal from at least one electrode during the electrochemical reaction over a series of time intervals to obtain a magnitude of the output signal for each time interval; determine an output differential (ΔI) as a difference in the respective magnitudes of the output signal for at least two consecutive time intervals within a predetermined time window during the test measurement sequence; if the output differential (ΔI) is greater than a predetermined threshold (b) then increment an index value (x) as equal to the sum of both a previous value of the index (x) and the output differential (ΔI) and if the index (x) is greater or equal to a predetermined index value (a) then annunciate an error, otherwise calculate the glucose value from the output signal and annunciate the glucose value. a microcontroller coupled to a power source, memory and the plurality of electrodes of the biosensor (64; 66) and in which the microcontroller is configured to: drive a signal to the at least two electrodes when a fluid sample comprising glucose is deposited proximate the at least two electrodes to start a test measurement sequence for an electrochemical reaction of the glucose in the fluid sample with the reagent; measure an output signal from at least one electrode during the electrochemical reaction over a series of time intervals to obtain a magnitude of the output signal for each time interval; determine an output differential (ΔI) as a difference in the respective magnitudes of the output signal for at least two consecutive time intervals within a predetermined time window during the test measurement sequence; if the output differential (ΔI) is greater than a predetermined threshold (b) then increment an index value (x) as equal to the sum of both a previous value of the index (x) and the output differential (ΔI) and if the index (x) is greater or equal to a predetermined index value (a) then annunciate an error, otherwise calculate the glucose value from the output signal and annunciate the glucose value. drive a signal to the at least two electrodes when a fluid sample comprising glucose is deposited proximate the at least two electrodes to start a test measurement sequence for an electrochemical reaction of the glucose in the fluid sample with the reagent; measure an output signal from at least one electrode during the electrochemical reaction over a series of time intervals to obtain a magnitude of the output signal for each time interval; determine an output differential (ΔI) as a difference in the respective magnitudes of the output signal for at least two consecutive time intervals within a predetermined time window during the test measurement sequence; if the output differential (ΔI) is greater than a predetermined threshold (b) then increment an index value (x) as equal to the sum of both a previous value of the index (x) and the output differential (ΔI) and if the index (x) is greater or equal to a predetermined index value (a) then annunciate an error, otherwise calculate the glucose value from the output signal and annunciate the glucose value.