A system comprising: a pulse generator; one or more electrodes; a controller configured to: control the pulse generator to deliver through one or more electrodes a temporal pattern of spinal cord stimulation where the temporal pattern of stimulation has an average stimulation frequency, wherein the temporal pattern of SCS includes a first pattern of electrical stimulation through the one or more electrodes to a first sub-population of targeted neurological tissue of a subject and a second pattern of electrical stimulation through the one or more electrodes to a second sub-population of targeted neurological tissue of the subject, wherein the first pattern has a first stimulation frequency and the second pattern has a different second stimulation frequency; and an external computing device configured to: determine the temporal pattern, including the average stimulation frequency, based on simulated neuronal output that results from simulated delivery of the first pattern of electrical stimulation to the first sub-population of targeted neurological tissue and the second pattern of electrical stimulation to the second sub-population of the targeted neurological tissue. a pulse generator; one or more electrodes; a controller configured to: control the pulse generator to deliver through one or more electrodes a temporal pattern of spinal cord stimulation where the temporal pattern of stimulation has an average stimulation frequency, wherein the temporal pattern of SCS includes a first pattern of electrical stimulation through the one or more electrodes to a first sub-population of targeted neurological tissue of a subject and a second pattern of electrical stimulation through the one or more electrodes to a second sub-population of targeted neurological tissue of the subject, wherein the first pattern has a first stimulation frequency and the second pattern has a different second stimulation frequency; and an external computing device configured to: determine the temporal pattern, including the average stimulation frequency, based on simulated neuronal output that results from simulated delivery of the first pattern of electrical stimulation to the first sub-population of targeted neurological tissue and the second pattern of electrical stimulation to the second sub-population of the targeted neurological tissue. control the pulse generator to deliver through one or more electrodes a temporal pattern of spinal cord stimulation where the temporal pattern of stimulation has an average stimulation frequency, wherein the temporal pattern of SCS includes a first pattern of electrical stimulation through the one or more electrodes to a first sub-population of targeted neurological tissue of a subject and a second pattern of electrical stimulation through the one or more electrodes to a second sub-population of targeted neurological tissue of the subject, wherein the first pattern has a first stimulation frequency and the second pattern has a different second stimulation frequency; and an external computing device configured to: determine the temporal pattern, including the average stimulation frequency, based on simulated neuronal output that results from simulated delivery of the first pattern of electrical stimulation to the first sub-population of targeted neurological tissue and the second pattern of electrical stimulation to the second sub-population of the targeted neurological tissue.