A method for determining a glucose concentration of a fluid sample measurable with a system having a test strip and a meter having a test circuit including a microprocessor, the method comprising: applying, with the test circuit, a first test voltage between a reference electrode and a second working electrode coated with a reagent layer of the test strip and applying a second test voltage between the reference electrode and a first working electrode coated with a reagent layer, wherein the first and second test voltages are applied as soon as the fluid sample is detected on the test strip; determining, with the microprocessor, a glucose concentration based on first, second, third and fourth test currents measured at the second working electrode and a fifth test current measured at the first working electrode, wherein the first, second, third, fourth and fifth test currents are measured at first, second, third, fourth and fifth discrete intervals after application of the test voltages by the meter; and annunciating the glucose concentration, in which the glucose concentration comprises a value obtained with an equation of the form: G = I 1 I 2 a − b I 3 I 4 × I 5 − intercept slope where: G is the glucose concentration; l 1 is the first test current; l 2 is the second test current; l 3 is the third test current; l 4 is the fourth test current; l 5 is the fifth test current; a is a first tuning parameter and b is a second tuning parameter; intercept is an intercept value determined from a linear regression of a plot of I 1 I 2 a − b I 3 I 4 × I 5 versus a reference glucose concentration; and slope is a slope value determined from a linear regression of a plot of I 1 I 2 a − b I 3 I 4 × I 5 versus the reference glucose concentration. applying, with the test circuit, a first test voltage between a reference electrode and a second working electrode coated with a reagent layer of the test strip and applying a second test voltage between the reference electrode and a first working electrode coated with a reagent layer, wherein the first and second test voltages are applied as soon as the fluid sample is detected on the test strip; determining, with the microprocessor, a glucose concentration based on first, second, third and fourth test currents measured at the second working electrode and a fifth test current measured at the first working electrode, wherein the first, second, third, fourth and fifth test currents are measured at first, second, third, fourth and fifth discrete intervals after application of the test voltages by the meter; and annunciating the glucose concentration, in which the glucose concentration comprises a value obtained with an equation of the form: G = I 1 I 2 a − b I 3 I 4 × I 5 − intercept slope where: G is the glucose concentration; l 1 is the first test current; l 2 is the second test current; l 3 is the third test current; l 4 is the fourth test current; l 5 is the fifth test current; a is a first tuning parameter and b is a second tuning parameter; intercept is an intercept value determined from a linear regression of a plot of I 1 I 2 a − b I 3 I 4 × I 5 versus a reference glucose concentration; and slope is a slope value determined from a linear regression of a plot of I 1 I 2 a − b I 3 I 4 × I 5 versus the reference glucose concentration.