A compound of structural Formula I or a salt or tautomer thereof, wherein: a is selected from 0 and 1; b is selected from 0 and 1; R 1 is selected from halo, C 6-10 aryl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, and a 5-9 membered heteroaryl group containing 1 to 4 heteroatoms or groups independently selected from N, C, O, and S; said aryl or heteroaryl of R 1 is optionally substituted with 1 to 5 R 12 groups independently selected from halo, hydroxy, amino, C 1-4 alkylamino, C 1-4 dialkylamino, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 hydroxyalkyl, C 1-4 haloalkyl, C 1-4 aminoalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, NR 15 C R 13, NR 15 C OR 13, NR 13 C NR 15 R 16, NR 15 S R 13, NR 15 S 2 R 13, C NR 15 R 16, S NR 15 R 16, S 2 NR 15 R 16, C R 13, C OR 13, SR 13, S R 13, and S 2 R 13; R 2, R 3, R 10, and R 11 are independently selected from hydrogen, C 1-4 alkyl, and C 3-8 cycloalkyl; R 4, R 5, Rs, and R 9 are independently selected from hydrogen, cyano, C 1-4 alkyl, C 1-4 alkoxy, amino, hydroxy, C 3-8 cycloalkyl, halo, and C 1-4 alkylamino; R 6 is selected from amino, C 1-4 aminoalkyl, and C 1-4 alkylamino; R 7 is selected from hydrogen, cyano, amido, halo, and hydroxy, or is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl, C 3-6 cycloalkyl, phenyl, and 5- or 6- membered heteroaryl, any of which is optionally substituted with one or more R 17 groups; or R 6 and R 7 together with the carbon atom to which they are both attached form a 3- to 7- membered saturated or unsaturated ring that can contain 1 to 3 heteroatoms or groups independently selected from N, C, O, and S m, which is optionally substituted with one R 17 group and is optionally substituted with one or more R 18 groups; m is selected from 0,1, and 2; any two groups selected from R 2, R 3, R 4, R 5, R 7, R 8, R 9, R 10 and R 11 can form a 5- to 6-membered ring, optionally containing a N, O or S heteroatom; any two groups selected from R 2, R 4, R 6, R 8 and R 10 can form a direct bond, or a 1 or 2 atom carbon bridge; R 13, R 15, and R 16 are independently selected from hydrogen, C 1-4 alkyl, and C 3-8 cycloakyl, wherein said alkyl or cycloalkyl is optionally substituted by one or more substituents selected from hydroxy, cyano and halo; and each R 17 and R 18 is independently selected from amino, halo, hydroxy, cyano, trifluoromethyl, trifluoromethoxy, C 1-4 alkyl, and C 1-4 alkoxy. a is selected from 0 and 1; b is selected from 0 and 1; R 1 is selected from halo, C 6-10 aryl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, and a 5-9 membered heteroaryl group containing 1 to 4 heteroatoms or groups independently selected from N, C, O, and S; said aryl or heteroaryl of R 1 is optionally substituted with 1 to 5 R 12 groups independently selected from halo, hydroxy, amino, C 1-4 alkylamino, C 1-4 dialkylamino, cyano, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 hydroxyalkyl, C 1-4 haloalkyl, C 1-4 aminoalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, NR 15 C R 13, NR 15 C OR 13, NR 13 C NR 15 R 16, NR 15 S R 13, NR 15 S 2 R 13, C NR 15 R 16, S NR 15 R 16, S 2 NR 15 R 16, C R 13, C OR 13, SR 13, S R 13, and S 2 R 13; R 2, R 3, R 10, and R 11 are independently selected from hydrogen, C 1-4 alkyl, and C 3-8 cycloalkyl; R 4, R 5, Rs, and R 9 are independently selected from hydrogen, cyano, C 1-4 alkyl, C 1-4 alkoxy, amino, hydroxy, C 3-8 cycloalkyl, halo, and C 1-4 alkylamino; R 6 is selected from amino, C 1-4 aminoalkyl, and C 1-4 alkylamino; R 7 is selected from hydrogen, cyano, amido, halo, and hydroxy, or is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl, C 3-6 cycloalkyl, phenyl, and 5- or 6- membered heteroaryl, any of which is optionally substituted with one or more R 17 groups; or R 6 and R 7 together with the carbon atom to which they are both attached form a 3- to 7- membered saturated or unsaturated ring that can contain 1 to 3 heteroatoms or groups independently selected from N, C, O, and S m, which is optionally substituted with one R 17 group and is optionally substituted with one or more R 18 groups; m is selected from 0,1, and 2; any two groups selected from R 2, R 3, R 4, R 5, R 7, R 8, R 9, R 10 and R 11 can form a 5- to 6-membered ring, optionally containing a N, O or S heteroatom; any two groups selected from R 2, R 4, R 6, R 8 and R 10 can form a direct bond, or a 1 or 2 atom carbon bridge; R 13, R 15, and R 16 are independently selected from hydrogen, C 1-4 alkyl, and C 3-8 cycloakyl, wherein said alkyl or cycloalkyl is optionally substituted by one or more substituents selected from hydroxy, cyano and halo; and each R 17 and R 18 is independently selected from amino, halo, hydroxy, cyano, trifluoromethyl, trifluoromethoxy, C 1-4 alkyl, and C 1-4 alkoxy.