An enteral feeding device for hydrolyzing triglycerides in a nutritional formula 110 by exposing the nutritional formula to lipase, the device comprising: a body 210 housing a chamber 222; an inlet 212 configured to fluidly couple with a source of nutritional formula 110, allowing the nutritional formula 110 to enter the device from the source and flow into the chamber 222; an outlet 230 configured to fluidly couple with an enteral feeding tube 124, allowing the nutritional formula 110 to exit the chamber 222 and flow into the enteral feeding tube 124; a plurality of particles 300 contained within the chamber 222, wherein the lipase is bonded to the plurality of particles 300; a headspace 223 contained within the chamber 222 defining a space not occupied by the plurality of particles; an inlet filter 250 located between the inlet 212 and the chamber 222, wherein the inlet filter 250 contains a first plurality of openings; and an outlet filter 260 located between the chamber 222 and the outlet 230, wherein the outlet filter 260 has a second plurality of openings, and wherein the second plurality of openings are smaller than the plurality of particles 300; wherein the triglycerides in the nutritional formula 110 are hydrolyzed as they pass through the plurality of particles 300 contained within the chamber 222; characterized in that the plurality of particles 300 are configured to transition from a dry configuration to a wet configuration when exposed to the nutritional formula 110 during an enteral feeding; wherein, in the dry configuration, the plurality of particles have a moisture level of 0.1 % to 5%, and wherein, in the wet configuration, the plurality of particles swell in volume by no more than 15%, thereby reducing the amount of headspace 223 contained within the chamber. a body 210 housing a chamber 222; an inlet 212 configured to fluidly couple with a source of nutritional formula 110, allowing the nutritional formula 110 to enter the device from the source and flow into the chamber 222; an outlet 230 configured to fluidly couple with an enteral feeding tube 124, allowing the nutritional formula 110 to exit the chamber 222 and flow into the enteral feeding tube 124; a plurality of particles 300 contained within the chamber 222, wherein the lipase is bonded to the plurality of particles 300; a headspace 223 contained within the chamber 222 defining a space not occupied by the plurality of particles; an inlet filter 250 located between the inlet 212 and the chamber 222, wherein the inlet filter 250 contains a first plurality of openings; and an outlet filter 260 located between the chamber 222 and the outlet 230, wherein the outlet filter 260 has a second plurality of openings, and wherein the second plurality of openings are smaller than the plurality of particles 300; wherein the triglycerides in the nutritional formula 110 are hydrolyzed as they pass through the plurality of particles 300 contained within the chamber 222; characterized in that the plurality of particles 300 are configured to transition from a dry configuration to a wet configuration when exposed to the nutritional formula 110 during an enteral feeding; wherein, in the dry configuration, the plurality of particles have a moisture level of 0.1 % to 5%, and wherein, in the wet configuration, the plurality of particles swell in volume by no more than 15%, thereby reducing the amount of headspace 223 contained within the chamber.