An antibody molecule-drug conjugate comprising an anti-LPS antibody molecule and a covalently coupled antimicrobial peptide, wherein the antibody molecule comprises: (i) a heavy chain variable region comprising: (a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; or (b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and (ii) a light chain variable region comprising: an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138, an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142, and an LCDR3 comprising the amino acid sequence of any of SEQ ID NO: 112; and (iii) a modified sulfatase motif having the formula: X 1 (FGly')X 2 Z 2 X 3 Z 3 where FGly' has the formula: wherein J 1 is the covalently coupled antimicrobial peptide; each L 1 is a divalent moiety independently selected from alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, alkynylene, arylene, substituted arylene, cycloalkylene, substituted cycloalkylene, heteroarylene, substituted heteroarylene, heterocyclene, substituted heterocyclene, acyl, amido, acyloxy, urethanylene, thioester, sulfonyl, sulfonamide, sulfonyl ester, -O-, -S-, -NH-, and substituted amine; n is a number selected from zero to 40; Z 2 is a proline or alanine residue; X 1 is present or absent and, when present, is any amino acid, with the proviso that when the sulfatase motif is at an N-terminus of the polypeptide, X 1 is present; X 2 and X 3 are each independently any amino acid; and Z 3 is a basic amino acid; and wherein the antimicrobial peptide comprises the amino acid sequence of GGGKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF (SEQ ID NO: 156). wherein the antibody molecule comprises: (i) a heavy chain variable region comprising: (a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; or (b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and (ii) a light chain variable region comprising: an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138, an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142, and an LCDR3 comprising the amino acid sequence of any of SEQ ID NO: 112; and (iii) a modified sulfatase motif having the formula: X 1 (FGly')X 2 Z 2 X 3 Z 3 (i) a heavy chain variable region comprising: (a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; or (b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and (a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; or (b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and (ii) a light chain variable region comprising: an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138, an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142, and an LCDR3 comprising the amino acid sequence of any of SEQ ID NO: 112; and (iii) a modified sulfatase motif having the formula: X 1 (FGly')X 2 Z 2 X 3 Z 3 where FGly' has the formula: wherein J 1 is the covalently coupled antimicrobial peptide; each L 1 is a divalent moiety independently selected from alkylene, substituted alkylene, alkenylene, substituted alkenylene, alkynylene, alkynylene, arylene, substituted arylene, cycloalkylene, substituted cycloalkylene, heteroarylene, substituted heteroarylene, heterocyclene, substituted heterocyclene, acyl, amido, acyloxy, urethanylene, thioester, sulfonyl, sulfonamide, sulfonyl ester, -O-, -S-, -NH-, and substituted amine; n is a number selected from zero to 40; Z 2 is a proline or alanine residue; X 1 is present or absent and, when present, is any amino acid, with the proviso that when the sulfatase motif is at an N-terminus of the polypeptide, X 1 is present; X 2 and X 3 are each independently any amino acid; and Z 3 is a basic amino acid; and wherein the antimicrobial peptide comprises the amino acid sequence of GGGKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF (SEQ ID NO: 156).