A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 each represent independently for each occurrence hydrogen, deuterium, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuteroalkyl, C 1-4 alkoxyl, -(C 1-4 alkylene)-(2-6 membered heteroalkyl), cyclopropyl, cyano, halogen, hydroxyl, or -N(R 4) 2; R 3 represents independently for each occurrence hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; R 4 represents independently for each occurrence hydrogen, C 1-4 alkyl, cyclopropyl, or -C R 3; R 5 represents independently for each occurrence C 1-4 alkyl or C 3-6 cycloalkyl; X 1 is one of the following: (a) a carbonyl-containing linker selected from -C N -ψ, -C N (C 1-6 alkylene)-ψ, and -C -(3-6 membered heterocycloalkylene containing at least one ring -N - group)-ψ; where ψ is a bond to A 1; or (b) an amine-containing linker selected from -(C 1-4 alkylene)-N -ψ and -(C 1-4 alkylene)-N -(C 1-4 alkylene)-ψ; A 1 is C 3-10 cycloalkyl, which is substituted by 1 or 2 occurrences of Y 1 and 0, 1, 2, or 3 occurrences of Y 2; Y 1 represents, independently for each occurrence, one of the following: • 2-8 membered heteroalkyl optionally substituted by a 6-10 membered aryl, a 3-10 membered heterocyclyl, or C 3-6 halocycloalkyl; • 3-10 membered heterocyclyl, 6-10 membered aryl, C 3-7 cycloalkyl, -O-C 3-7 cycloalkyl, -O-(3-6 membered heterocyclyl), -0-(6-10 membered aryl), or -O-(C 2-6 alkynyl); • C 2-6 alkynyl, -C≡C-(C 1-6 alkylene)-OR 4, -C≡C-(C 1-6 alkylene)-N(R 3) 2, -(C 2-4 alkynylene)-(5-6 membered heteroaryl), or C 2-6 alkenyl; or • C 1-6 haloalkyl, C 1-6 alkyl, halogen, cyano, -CO 2 R 3, -C R 5, -S 2 R 5, -C N(R 5) 2, -C N(R 3) 2, -N(R 3)C R 5, or -O-(C 1-8 haloalkyl); Y 2 represents, independently for each occurrence, deuterium, C 1-6 alkyl, C 3-6 cycloalkyl, halogen, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, hydroxyl, C 1-6 alkoxyl, cyano, azido,-N(R 3) 2, -(C 1-6 alkylene)-(5-6 membered heterocyclyl), -(C 1-6 alkylene)-CO 2 R 3, or C 1-6 haloalkyl-substituted C 3-6 cycloalkyl; m is 1 or 2; and n is 1, 2, or 3. R 1 and R 2 each represent independently for each occurrence hydrogen, deuterium, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 deuteroalkyl, C 1-4 alkoxyl, -(C 1-4 alkylene)-(2-6 membered heteroalkyl), cyclopropyl, cyano, halogen, hydroxyl, or -N(R 4) 2; R 3 represents independently for each occurrence hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; R 4 represents independently for each occurrence hydrogen, C 1-4 alkyl, cyclopropyl, or -C R 3; R 5 represents independently for each occurrence C 1-4 alkyl or C 3-6 cycloalkyl; X 1 is one of the following: (a) a carbonyl-containing linker selected from -C N -ψ, -C N (C 1-6 alkylene)-ψ, and -C -(3-6 membered heterocycloalkylene containing at least one ring -N - group)-ψ; where ψ is a bond to A 1; or (b) an amine-containing linker selected from -(C 1-4 alkylene)-N -ψ and -(C 1-4 alkylene)-N -(C 1-4 alkylene)-ψ; (a) a carbonyl-containing linker selected from -C N -ψ, -C N (C 1-6 alkylene)-ψ, and -C -(3-6 membered heterocycloalkylene containing at least one ring -N - group)-ψ; where ψ is a bond to A 1; or (b) an amine-containing linker selected from -(C 1-4 alkylene)-N -ψ and -(C 1-4 alkylene)-N -(C 1-4 alkylene)-ψ; A 1 is C 3-10 cycloalkyl, which is substituted by 1 or 2 occurrences of Y 1 and 0, 1, 2, or 3 occurrences of Y 2; Y 1 represents, independently for each occurrence, one of the following: • 2-8 membered heteroalkyl optionally substituted by a 6-10 membered aryl, a 3-10 membered heterocyclyl, or C 3-6 halocycloalkyl; • 3-10 membered heterocyclyl, 6-10 membered aryl, C 3-7 cycloalkyl, -O-C 3-7 cycloalkyl, -O-(3-6 membered heterocyclyl), -0-(6-10 membered aryl), or -O-(C 2-6 alkynyl); • C 2-6 alkynyl, -C≡C-(C 1-6 alkylene)-OR 4, -C≡C-(C 1-6 alkylene)-N(R 3) 2, -(C 2-4 alkynylene)-(5-6 membered heteroaryl), or C 2-6 alkenyl; or • C 1-6 haloalkyl, C 1-6 alkyl, halogen, cyano, -CO 2 R 3, -C R 5, -S 2 R 5, -C N(R 5) 2, -C N(R 3) 2, -N(R 3)C R 5, or -O-(C 1-8 haloalkyl); • 2-8 membered heteroalkyl optionally substituted by a 6-10 membered aryl, a 3-10 membered heterocyclyl, or C 3-6 halocycloalkyl; • 3-10 membered heterocyclyl, 6-10 membered aryl, C 3-7 cycloalkyl, -O-C 3-7 cycloalkyl, -O-(3-6 membered heterocyclyl), -0-(6-10 membered aryl), or -O-(C 2-6 alkynyl); • C 2-6 alkynyl, -C≡C-(C 1-6 alkylene)-OR 4, -C≡C-(C 1-6 alkylene)-N(R 3) 2, -(C 2-4 alkynylene)-(5-6 membered heteroaryl), or C 2-6 alkenyl; or • C 1-6 haloalkyl, C 1-6 alkyl, halogen, cyano, -CO 2 R 3, -C R 5, -S 2 R 5, -C N(R 5) 2, -C N(R 3) 2, -N(R 3)C R 5, or -O-(C 1-8 haloalkyl); Y 2 represents, independently for each occurrence, deuterium, C 1-6 alkyl, C 3-6 cycloalkyl, halogen, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, hydroxyl, C 1-6 alkoxyl, cyano, azido,-N(R 3) 2, -(C 1-6 alkylene)-(5-6 membered heterocyclyl), -(C 1-6 alkylene)-CO 2 R 3, or C 1-6 haloalkyl-substituted C 3-6 cycloalkyl; m is 1 or 2; and n is 1, 2, or 3.