A compound of the Formula: or a pharmaceutically acceptable salt thereof; wherein: Ring A is substituted or unsubstituted aryl or heteroaryl; R 1 is hydrogen, or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl; each of R 2a and R 2b is independently selected from hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -N(R A)(R B), or -OR A2, wherein each of R A and R B is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubsituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or R A and R B, together with the nitrogen atom to which they are attached form a ring (e.g., heteroaryl, heterocyclyl), or R 2a and R 2b, together with the carbon atom to which they are attached form a ring; R A2 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3a is hydrogen, -N(R A)(R B), or -OR A3, wherein R A3 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and R 3b is hydrogen or -N(R A)C R A3; or R 3a and R 3b are joined to form an oxo (=O) group; each of R 4a and R 4b is independently selected from hydrogen or halogen; R 5 is hydrogen, unsubstituted C 1-6 alkyl, or - CH 2 OR A5, wherein R A5 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 6 is absent or hydrogen; and ------ represents a single or double bond, wherein when one of ------ is a double bond, the other ------ is a single bond; and when one of the ------ is a double bond, R 6 is absent. Ring A is substituted or unsubstituted aryl or heteroaryl; R 1 is hydrogen, or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl; each of R 2a and R 2b is independently selected from hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -N(R A)(R B), or -OR A2, wherein each of R A and R B is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubsituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or R A and R B, together with the nitrogen atom to which they are attached form a ring (e.g., heteroaryl, heterocyclyl), or R 2a and R 2b, together with the carbon atom to which they are attached form a ring; R A2 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3a is hydrogen, -N(R A)(R B), or -OR A3, wherein R A3 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and R 3b is hydrogen or -N(R A)C R A3; or R 3a and R 3b are joined to form an oxo (=O) group; each of R 4a and R 4b is independently selected from hydrogen or halogen; R 5 is hydrogen, unsubstituted C 1-6 alkyl, or - CH 2 OR A5, wherein R A5 is hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 6 is absent or hydrogen; and ------ represents a single or double bond, wherein when one of ------ is a double bond, the other ------ is a single bond; and when one of the ------ is a double bond, R 6 is absent.