A method for the synthesis of a target peptide comprising a first cycle peptide P-1, wherein the method comprises the following steps: (a) providing a first component C-1 being selected from the group consisting of an amino acid and a peptide and comprising one free primary or secondary aliphatic amino group, wherein any other primary or secondary aliphatic amino groups and any carboxyl groups in C-1 are protected, (b) providing a second component C-2 being selected from the group consisting of a chiral alpha-amino acid and a peptide and comprising one free carboxyl group, which is the alpha-carboxyl group of a chiral alpha-amino acid moiety comprising one hydrogen-substituent bonded to the alpha-carbon atom, wherein any primary or secondary aliphatic amino groups and any other carboxyl groups in C-2 are protected, and (c) condensing the first component C-1 of step (a) and the second component C-2 of step (b) in the presence of: - a carbodiimide coupling agent, - a first additive A-1 of formula A-I: wherein in formula A-I, R 1 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 5 -alkyl, and an electron-withdrawing substituent, - a second additive A-2 selected from the group consisting of ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma), 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), 5-(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione (Oxyma-B), and ethyl 1-hydroxy-1,2,3-triazole-4-carboxylate (HOCt), or mixtures thereof, and - a first cycle solvent, so as to form an amide bond between the free primary or secondary aliphatic amino group of the first component C-1 and the free alpha-carboxyl group of the second component C-2, to obtain a first cycle peptide P-1, wherein in step (c), the second additive A-2 is used in a total molar amount of 1.0 to 5.0 equivalents relative to the total molar amount of the first component C-1. (a) providing a first component C-1 being selected from the group consisting of an amino acid and a peptide and comprising one free primary or secondary aliphatic amino group, wherein any other primary or secondary aliphatic amino groups and any carboxyl groups in C-1 are protected, (b) providing a second component C-2 being selected from the group consisting of a chiral alpha-amino acid and a peptide and comprising one free carboxyl group, which is the alpha-carboxyl group of a chiral alpha-amino acid moiety comprising one hydrogen-substituent bonded to the alpha-carbon atom, wherein any primary or secondary aliphatic amino groups and any other carboxyl groups in C-2 are protected, and (c) condensing the first component C-1 of step (a) and the second component C-2 of step (b) in the presence of: - a carbodiimide coupling agent, - a first additive A-1 of formula A-I: wherein in formula A-I, R 1 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 5 -alkyl, and an electron-withdrawing substituent, - a second additive A-2 selected from the group consisting of ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma), 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), 5-(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione (Oxyma-B), and ethyl 1-hydroxy-1,2,3-triazole-4-carboxylate (HOCt), or mixtures thereof, and - a first cycle solvent, so as to form an amide bond between the free primary or secondary aliphatic amino group of the first component C-1 and the free alpha-carboxyl group of the second component C-2, to obtain a first cycle peptide P-1, - a carbodiimide coupling agent, - a first additive A-1 of formula A-I: wherein in formula A-I, R 1 is at each occurrence independently selected from the group consisting of hydrogen, C 1 -C 5 -alkyl, and an electron-withdrawing substituent, - a second additive A-2 selected from the group consisting of ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma), 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), 5-(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione (Oxyma-B), and ethyl 1-hydroxy-1,2,3-triazole-4-carboxylate (HOCt), or mixtures thereof, and - a first cycle solvent,