A modular vial adapter for interconnecting a vial with a delivery device, the modular vial adapter comprising: a spike member comprising a base and a distal tip extending therefrom, the spike member further comprising at least: a first lumen extending from the base to the distal tip and providing a fluid pathway therethrough; and a second lumen separate from the first lumen and in communication with the distal tip, the second lumen providing a vent pathway for allowing atmospheric air to enter an interior space of the vial to prevent negative pressure buildup when fluid content is transported from the vial via the fluid pathway provided by the first lumen; a separately formed port member comprising a first end defining a base directly coupled to the base of the spike member and an opposing second end defining a connector assembly, the port member further comprising a channel extending therethrough from the first end to the second end and in fluid communication with the fluid pathway of the first lumen of the spike member upon coupling of the spike member base with the port member base; and a separately formed skirt member comprising a proximal end defining a base including a recess having a bore extending therethrough, wherein the recess is shaped and/or sized for receiving and retaining portions of the spike member and port member therein, the skirt member further comprising at least one side wall extending from the base and terminating at an open distal end to define a cavity shaped and/or sized to receive and engage a closure on a vial, wherein, upon positioning of a vial closure within the cavity of the skirt member, the distal tip of the spike member is configured to penetrate a seal of the vial and fluid content within the vial is available for transfer to a delivery device releasably coupled to at least the connector assembly of the port member via the fluid pathway from the distal tip of the spike member through the channel of the port member and out of the connector assembly of the port member. a first lumen extending from the base to the distal tip and providing a fluid pathway therethrough; and a second lumen separate from the first lumen and in communication with the distal tip, the second lumen providing a vent pathway for allowing atmospheric air to enter an interior space of the vial to prevent negative pressure buildup when fluid content is transported from the vial via the fluid pathway provided by the first lumen; a separately formed port member comprising a first end defining a base directly coupled to the base of the spike member and an opposing second end defining a connector assembly, the port member further comprising a channel extending therethrough from the first end to the second end and in fluid communication with the fluid pathway of the first lumen of the spike member upon coupling of the spike member base with the port member base; and a separately formed skirt member comprising a proximal end defining a base including a recess having a bore extending therethrough, wherein the recess is shaped and/or sized for receiving and retaining portions of the spike member and port member therein, the skirt member further comprising at least one side wall extending from the base and terminating at an open distal end to define a cavity shaped and/or sized to receive and engage a closure on a vial, wherein, upon positioning of a vial closure within the cavity of the skirt member, the distal tip of the spike member is configured to penetrate a seal of the vial and fluid content within the vial is available for transfer to a delivery device releasably coupled to at least the connector assembly of the port member via the fluid pathway from the distal tip of the spike member through the channel of the port member and out of the connector assembly of the port member.