A method for maximizing efficiency for a portable transceiver system said portable transceiver system comprising: a first transmitter and a second transmitter respectively coupled to a first antenna port and to a second antenna port for providing respectively a first RF output to a first antenna and a second RF output to a second antenna; first antenna matching network and second antenna matching network configured to facilitate impedance matching respectively between each of the first and second transmitters (130, 230) and the first and second antennas (120, 220); a control processor having access to a data store and configured to cause the portable transceiver system to execute a calibration mode and an operating mode, said method comprising: during the calibration mode, performing a first calibration by selectively varying one or more tuning parameters of the first antenna matching network, to determine a first optimized tuning control data for the first antenna matching network with the first transmitter coupled to the first antenna through the first antenna port, and the second transmitter of the portable transceiver system inactive; activating the second transmitter to communicate radio frequency energy to a second antenna coupled to a second antenna port of the portable transceiver system; while the second transmitter is active, performing a second calibration of the first antenna matching network by selectively varying the one or more tuning parameters of the first antenna matching network to determine a second optimized tuning control data; storing the first and second optimized tuning control data in the data store; and during the operational mode, controlling the one or more tuning parameters in accordance with the first optimized tuning control data when the second transmitter is not active, and with the second optimized tuning control data when the second transmitter is active. a first transmitter and a second transmitter respectively coupled to a first antenna port and to a second antenna port for providing respectively a first RF output to a first antenna and a second RF output to a second antenna; first antenna matching network and second antenna matching network configured to facilitate impedance matching respectively between each of the first and second transmitters (130, 230) and the first and second antennas (120, 220); a control processor having access to a data store and configured to cause the portable transceiver system to execute a calibration mode and an operating mode, said method comprising: during the calibration mode, performing a first calibration by selectively varying one or more tuning parameters of the first antenna matching network, to determine a first optimized tuning control data for the first antenna matching network with the first transmitter coupled to the first antenna through the first antenna port, and the second transmitter of the portable transceiver system inactive; activating the second transmitter to communicate radio frequency energy to a second antenna coupled to a second antenna port of the portable transceiver system; while the second transmitter is active, performing a second calibration of the first antenna matching network by selectively varying the one or more tuning parameters of the first antenna matching network to determine a second optimized tuning control data; storing the first and second optimized tuning control data in the data store; and during the operational mode, controlling the one or more tuning parameters in accordance with the first optimized tuning control data when the second transmitter is not active, and with the second optimized tuning control data when the second transmitter is active. during the calibration mode, performing a first calibration by selectively varying one or more tuning parameters of the first antenna matching network, to determine a first optimized tuning control data for the first antenna matching network with the first transmitter coupled to the first antenna through the first antenna port, and the second transmitter of the portable transceiver system inactive; activating the second transmitter to communicate radio frequency energy to a second antenna coupled to a second antenna port of the portable transceiver system; while the second transmitter is active, performing a second calibration of the first antenna matching network by selectively varying the one or more tuning parameters of the first antenna matching network to determine a second optimized tuning control data; storing the first and second optimized tuning control data in the data store; and during the operational mode, controlling the one or more tuning parameters in accordance with the first optimized tuning control data when the second transmitter is not active, and with the second optimized tuning control data when the second transmitter is active.