mhurhangee/ep-ind-claims huggingface dataset:
A method of generating a decellularized extracellular matrix of a myocardium tissue, comprising: (a) subjecting the myocardium tissue to a hypertonic buffer to thereby obtain increased intercellular space within the tissue; (b) subjecting the myocardium tissue resultant of step (a) to an enzymatic proteolytic digestion to thereby obtain digested cellular components within the myocardium tissue; (c) subjecting the tissue resultant of step (a) to a nuclease treatment to thereby obtain nucleic acid - free tissue; and subsequently (d) removing said digested cellular components from the myocardium tissue, such that the decellularized ECM of the myocardium tissue preserves the mechanical properties of the myocardium tissue ECM prior to decellularization, is completely devoid of cellular components and can be remodeled upon seeding with cells. (a) subjecting the myocardium tissue to a hypertonic buffer to thereby obtain increased intercellular space within the tissue; (b) subjecting the myocardium tissue resultant of step (a) to an enzymatic proteolytic digestion to thereby obtain digested cellular components within the myocardium tissue; (c) subjecting the tissue resultant of step (a) to a nuclease treatment to thereby obtain nucleic acid - free tissue; and subsequently (d) removing said digested cellular components from the myocardium tissue,
A therapeutic agent for use in treating an RNA viral infection, which comprises a combination of a pyrazine derivative represented by the following formula or a salt thereof and one or more types of compounds selected from the group consisting of an antifolate, a thiopurine antimetabolite, thiazofurin, an alkylating agent, and a xanthine derivative: wherein R 1 and R 2, which are the same or different, each represent a hydrogen atom or a halogen atom; and R 3 represents a hydrogen atom or an amino-protecting group, and wherein the antifolate is methotrexate or pralatrexate, the thiopurine antimetabolite is a mercaptopurine derivative represented by the following formula: wherein R 4 represents a hydrogen atom or an optionally protected amino group; and R 5 represents a hydrogen atom or the following formula: (wherein R 6 represents a hydrogen atom, a C 1-6 alkyl group, or a carboxy group; and R 7 represents a hydrogen atom, a C 1-6 alkyl group, a benzyl group, or a p-nitrobenzyl group), the alkylating agent is temozolomide, and the xanthine derivative is theophylline. the antifolate is methotrexate or pralatrexate, the thiopurine antimetabolite is a mercaptopurine derivative represented by the following formula: wherein R 4 represents a hydrogen atom or an optionally protected amino group; and R 5 represents a hydrogen atom or the following formula: (wherein R 6 represents a hydrogen atom, a C 1-6 alkyl group, or a carboxy group; and R 7 represents a hydrogen atom, a C 1-6 alkyl group, a benzyl group, or a p-nitrobenzyl group), the alkylating agent is temozolomide, and the xanthine derivative is theophylline.
Process for the production of metallic components by means of generative manufacture, where a metal powder layer is produced in an evacuated irradiation chamber and is selectively melted or sintered via exposure to an energy beam to give a workpiece contour, and after manufacture of the workpiece contour has been concluded the irradiation chamber is flooded with a cooling gas, where the molten or sintered portion of the metal powder solidifies to give a solid workpiece contour, where a hydrogen-containing gas or gas mixture is used as cooling gas, characterized in that the cooling gas comprises a proportion of 0.5% by volume to 30% by volume of hydrogen, the remainder being helium and/or argon and/or nitrogen, or comprises a proportion of 97% by volume to 99.5% by volume of hydrogen and 0.5% by volume to 3% by volume of helium, the remainder being argon and/or nitrogen.
Rolling-body cage made from a metal strip material which is profiled, punched, cut to length and bent around, the ends of the cut-to-length strip sections being connected to one another by way of welding, characterized in that the strip section ends (28, 30; 34, 36) have a predefined axial offset (a) and/or radial offset (b) with respect to one another.
A device for topically administering nitric oxide gas combined with a dilutent gas to an infected wound in the skin comprising: - a source of nitric oxide gas; - a source of dilutent gas, wherein the dilutent gas is an inert gas; - a gas blender for mixing nitric oxide gas with the dilutent gas, the gas blender in fluid communication with the source of nitric oxide gas and the source of dilutent gas and having an output containing a nitric oxide gas mixture; - a bathing unit being adapted for surrounding the area of the infected wound and forming a substantially air-tight seal with the skin surface; a flow control valve in fluid communication with the output of the gas blender for controlling the amount of nitric oxide gas mixture delivered to the bathing unit; - the bathing unit in fluid communication with the flow control valve, the bathing unit including an input and an output, the input being in fluid communication with the output of the flow control valve; - a vacuum unit in fluid communication with the bathing unit and positioned downstream of the bathing unit for withdrawing nitric oxide gas mixture from the bathing unit; - a nitric oxide gas absorber unit positioned upstream of the vacuum unit and downstream of the bathing unit; and - a controller for controlling the operation of the flow control valve and the vacuum unit. - a source of nitric oxide gas; - a source of dilutent gas, wherein the dilutent gas is an inert gas; - a gas blender for mixing nitric oxide gas with the dilutent gas, the gas blender in fluid communication with the source of nitric oxide gas and the source of dilutent gas and having an output containing a nitric oxide gas mixture; - a bathing unit being adapted for surrounding the area of the infected wound and forming a substantially air-tight seal with the skin surface; a flow control valve in fluid communication with the output of the gas blender for controlling the amount of nitric oxide gas mixture delivered to the bathing unit; - the bathing unit in fluid communication with the flow control valve, the bathing unit including an input and an output, the input being in fluid communication with the output of the flow control valve; - a vacuum unit in fluid communication with the bathing unit and positioned downstream of the bathing unit for withdrawing nitric oxide gas mixture from the bathing unit; - a nitric oxide gas absorber unit positioned upstream of the vacuum unit and downstream of the bathing unit; and - a controller for controlling the operation of the flow control valve and the vacuum unit.
A wireless communication system comprising a wireless communication network comprising wireless devices and one or more transmission points; the wireless communication network configured to: Transmit, via the one or more transmission points, information indicating a set of different synchronization signals for a wireless device to obtain or maintain synchronization with the wireless communication network and, Transmit, via the one or more transmission points, two or more synchronization signals corresponding to the set such that each synchronization signal is different from one another and corresponds to a different beam from among two or more beams used by a transmission point; and, wherein the wireless device is configured to maintain synchronization between the wireless device and the transmission point in conjunction with the wireless device moving between coverage areas corresponding to the two or more beams by dynamically synchronizing or resynchronizing with at least one of the synchronization signals in the set, wherein the wireless device is configured to not trigger a radio link failure as long as synchronisation can be obtained from the set. Transmit, via the one or more transmission points, information indicating a set of different synchronization signals for a wireless device to obtain or maintain synchronization with the wireless communication network and, Transmit, via the one or more transmission points, two or more synchronization signals corresponding to the set such that each synchronization signal is different from one another and corresponds to a different beam from among two or more beams used by a transmission point; and, wherein the wireless device is configured to maintain synchronization between the wireless device and the transmission point in conjunction with the wireless device moving between coverage areas corresponding to the two or more beams by dynamically synchronizing or resynchronizing with at least one of the synchronization signals in the set, wherein the wireless device is configured to not trigger a radio link failure as long as synchronisation can be obtained from the set.
A die positioning system for positioning a die of a system for mechanical die-based manufacture of threaded fasteners, comprising: a pair of key bars, each key bar of the pair of key bars having a solid rectangular cuboid configuration identical in thickness to the other key bar of the pair of key bars; a pair of key disc inserts, each key disc insert having at least one disc aperture extending therethrough; a set of key discs, each key disc of the set of key discs having a solid three dimensional configuration identical in thickness to all other key discs of the set of key discs, each key disc having a diameter equal to or less than a diameter of the at least one disc aperture and each key disc having a thickness equal to or greater than a thickness of a section of the key disc insert that the at least one disc aperture extends through; and a set of disc backers, wherein a forward surface of each disc backer comprises a backer surface having a non-planar configuration, said forward surface for placing behind a key disc. a pair of key bars, each key bar of the pair of key bars having a solid rectangular cuboid configuration identical in thickness to the other key bar of the pair of key bars; a pair of key disc inserts, each key disc insert having at least one disc aperture extending therethrough; a set of key discs, each key disc of the set of key discs having a solid three dimensional configuration identical in thickness to all other key discs of the set of key discs, each key disc having a diameter equal to or less than a diameter of the at least one disc aperture and each key disc having a thickness equal to or greater than a thickness of a section of the key disc insert that the at least one disc aperture extends through; and a set of disc backers, wherein a forward surface of each disc backer comprises a backer surface having a non-planar configuration, said forward surface for placing behind a key disc.
Drive system for a tractor, having at least one electrical generator (24, 26) which can be driven by a torque generated by an engine of the tractor, and having a first and a second electrical machine (28, 30) which can be driven by the electrical energy generated by the at least one electrical generator (24, 26), wherein the mechanical torque generated by the first and/or the second electrical machine (28, 30) can be transmitted to at least one drive axle (14, 16) of the tractor, for propelling the latter, characterized in that a mechanical interface in the form of a power take-off shaft (122, 152) is provided, via which a compound mechanical torque can be transmitted from the engine and from at least one of the two electrical machines (28, 30) to a mechanically driveable implement by means of a compound gearing.
A grafted seedling producing device comprising: a stock seedling holding unit that holds and conveys a stock seedling; a stock cutting unit that cuts the stock seedling held by the stock seedling holding unit; and a joining unit that joins the stock seedling conveyed by the stock seedling holding unit and a scion seedling, wherein the stock cutting unit includes a stock cutter unit that includes a stock blade for cutting the stock seedling by a predetermined stock cutter trajectory, the stock seedling holding unit holds an embryonic stem of a seedling for grafting at a predetermined position on the stock cutter trajectory in a vertical posture, characterized in that the stock cutting unit (76 L) further includes: a supporting unit configured to advance the stock cutter unit from a retracted position to an advanced position for cutting in proximity to the stock seedling holding unit, and a stock pressing member that presses and fixes a portion ahead of a cutting position of the embryonic stem from a seedling holding position against the stock seedling holding unit side at the advanced position. a stock seedling holding unit that holds and conveys a stock seedling; a stock cutting unit that cuts the stock seedling held by the stock seedling holding unit; and a joining unit that joins the stock seedling conveyed by the stock seedling holding unit and a scion seedling, wherein the stock cutting unit includes a stock cutter unit that includes a stock blade for cutting the stock seedling by a predetermined stock cutter trajectory, the stock seedling holding unit holds an embryonic stem of a seedling for grafting at a predetermined position on the stock cutter trajectory in a vertical posture, characterized in that the stock cutting unit (76 L) further includes: a supporting unit configured to advance the stock cutter unit from a retracted position to an advanced position for cutting in proximity to the stock seedling holding unit, and a stock pressing member that presses and fixes a portion ahead of a cutting position of the embryonic stem from a seedling holding position against the stock seedling holding unit side at the advanced position. a supporting unit configured to advance the stock cutter unit from a retracted position to an advanced position for cutting in proximity to the stock seedling holding unit, and a stock pressing member that presses and fixes a portion ahead of a cutting position of the embryonic stem from a seedling holding position against the stock seedling holding unit side at the advanced position.
A method comprising: a) providing a substrate having a thickness of 100 μm or greater with a plurality of through-holes comprising a layer of electroless copper, copper flash or combinations thereof on a surface of the substrate and walls of the plurality of through-holes; b) immersing the substrate in a copper electroplating bath comprising an anode; and c) filling the through-holes with copper by a direct current cycle comprising applying a first current density ranging from 1.5-4 ASD for a first predetermined period of time followed by turning off direct current for a second predetermined period of time and then turning on the direct current and applying a second lower current density ranging from 0.5-3 ASD for a third predetermined period of time, wherein the first predetermined period of time is shorter than the third predetermined period of time. a) providing a substrate having a thickness of 100 μm or greater with a plurality of through-holes comprising a layer of electroless copper, copper flash or combinations thereof on a surface of the substrate and walls of the plurality of through-holes; b) immersing the substrate in a copper electroplating bath comprising an anode; and c) filling the through-holes with copper by a direct current cycle comprising applying a first current density ranging from 1.5-4 ASD for a first predetermined period of time followed by turning off direct current for a second predetermined period of time and then turning on the direct current and applying a second lower current density ranging from 0.5-3 ASD for a third predetermined period of time, wherein the first predetermined period of time is shorter than the third predetermined period of time.
An assembly comprising a component adhered to a support apparatus, the support apparatus comprising: a peripheral body entirely disposed within the footprint of the component, when the component is mounted on a surface of a substrate, the peripheral body comprising: a first portion having a first surface adhesively connected to the component; a second portion having a second surface disposable on the surface of the substrate, the second surface comprising discrete sectors; an aperture through which leads from the component extend, the leads being suitable for soldering in lead holes of the substrate; and vents extending between the discrete sectors from the aperture to the periphery of the peripheral body, wherein the support apparatus further comprises bosses disposed on the peripheral body to protrude from the second surface for securing the support apparatus into through-holes of the substrate, and wherein the second portion, at the vents, comprises: third surfaces parallel to and recessed from a plane of the second surface; and fourth surfaces oriented transversely with respect to the first, second and third surfaces. a first portion having a first surface adhesively connected to the component; a second portion having a second surface disposable on the surface of the substrate, the second surface comprising discrete sectors; an aperture through which leads from the component extend, the leads being suitable for soldering in lead holes of the substrate; and vents extending between the discrete sectors from the aperture to the periphery of the peripheral body, wherein the support apparatus further comprises bosses disposed on the peripheral body to protrude from the second surface for securing the support apparatus into through-holes of the substrate, and wherein the second portion, at the vents, comprises: third surfaces parallel to and recessed from a plane of the second surface; and fourth surfaces oriented transversely with respect to the first, second and third surfaces. third surfaces parallel to and recessed from a plane of the second surface; and fourth surfaces oriented transversely with respect to the first, second and third surfaces.
A method for processing upstream data abnormity, comprising: an optical line terminal, OLT, detecting that upstream data is abnormal; and characterized by the OLT instructing one or more optical network units, ONUs, to change a physical channel; the OLT determining an abnormal ONU in the one or more ONUs which causes the upstream data to be abnormal according to whether the upstream data is back to normal. an optical line terminal, OLT, detecting that upstream data is abnormal; and characterized by the OLT instructing one or more optical network units, ONUs, to change a physical channel; the OLT determining an abnormal ONU in the one or more ONUs which causes the upstream data to be abnormal according to whether the upstream data is back to normal.
Method for determining a maximum settable torque (M min, M max) of an electrical machine in a motor and/or generator operation for a current operating point, wherein a current maximum settable voltage (U dc) and a current angular frequency (ω el) of the electrical machine are determined, characterised in that, using a maximum permissible excitation current (I ex,max) for the electrical machine, parameters of the electrical machine and, from this, using a maximum permissible phase current (I dq,Limit) and a maximum permissible total current (I dc,Limit) for the motor operation and/or the generator operation, variables comprising a maximum possible q-current (I q,min, I q,max) and a maximum possible d-current (I d,min, I d,max), in each case for the motor operation and/or the generator operation, are determined iteratively, a maximum possible torque (M min, M max) of the electrical machine for motor and/or generator operation being determined from the variables, and a determined value for the maximum possible torque for motor and/or generator operation being made available via an interface. wherein a current maximum settable voltage (U dc) and a current angular frequency (ω el) of the electrical machine are determined, characterised in that, using a maximum permissible excitation current (I ex,max) for the electrical machine, parameters of the electrical machine and, from this, using a maximum permissible phase current (I dq,Limit) and a maximum permissible total current (I dc,Limit) for the motor operation and/or the generator operation, variables comprising a maximum possible q-current (I q,min, I q,max) and a maximum possible d-current (I d,min, I d,max), in each case for the motor operation and/or the generator operation, are determined iteratively, a maximum possible torque (M min, M max) of the electrical machine for motor and/or generator operation being determined from the variables, and a determined value for the maximum possible torque for motor and/or generator operation being made available via an interface.
A thermographic temperature sensor, comprising: a probe comprising a housing, the housing comprising a sheath, and the probe further comprising a light pipe disposed within the sheath, wherein: the light pipe comprises a thermographic phosphor configured to phosphoresce in response to absorbing light, wherein the phosphorescence by the thermographic phosphor is representative of a temperature of a fluid in contact with the probe; the sensor being characterised in that the sheath comprises a plurality of holes disposed from its outer surface to its inner surface, the holes being spaced apart along a longitudinal axis and a circumferential direction of the sheath; and the sensor further comprising a plurality of supports configured to secure the light pipe to the sheath, and an air gap disposed between an outer surface of the light pipe and the inner surface of the sheath, wherein the air gap circumferentially surrounds at least a portion of the light pipe, wherein each support of the plurality of supports is disposed within a hole of the plurality of holes of the sheath and radially extends between the outer surface of the sheath and the light pipe. a probe comprising a housing, the housing comprising a sheath, and the probe further comprising a light pipe disposed within the sheath, wherein: the light pipe comprises a thermographic phosphor configured to phosphoresce in response to absorbing light, wherein the phosphorescence by the thermographic phosphor is representative of a temperature of a fluid in contact with the probe; the sensor being characterised in that the sheath comprises a plurality of holes disposed from its outer surface to its inner surface, the holes being spaced apart along a longitudinal axis and a circumferential direction of the sheath; and the sensor further comprising the light pipe comprises a thermographic phosphor configured to phosphoresce in response to absorbing light, wherein the phosphorescence by the thermographic phosphor is representative of a temperature of a fluid in contact with the probe; the sensor being characterised in that the sheath comprises a plurality of holes disposed from its outer surface to its inner surface, the holes being spaced apart along a longitudinal axis and a circumferential direction of the sheath; and the sensor further comprising a plurality of supports configured to secure the light pipe to the sheath, and an air gap disposed between an outer surface of the light pipe and the inner surface of the sheath, wherein the air gap circumferentially surrounds at least a portion of the light pipe, wherein each support of the plurality of supports is disposed within a hole of the plurality of holes of the sheath and radially extends between the outer surface of the sheath and the light pipe.