A biomimetic microfluidic system comprising: a substrate (101, 902); a first channel (102, 904) formed in the substrate (101, 902), the first channel (102, 904) extending from a first input (106, 920) to a first output (106, 922) along a longitudinal direction, and extending along a first transverse direction; a second channel (104, 906) formed in the substrate (101, 902), the second channel (104, 906) extending from a second input (110, 924) to a second output (112, 926) along the longitudinal direction, and extending along the first transverse direction, wherein at least a portion of the first (102, 904) and second (104, 906) channels extend substantially parallel along the longitudinal direction; columns (114, 916) that separate the first channel (102, 904) and the second channel (104, 906) and extend along a second transverse direction; a series of apertures formed in between the columns (114, 916) proximal to a first portion of the substrate that create a fluid communication path between the first channel (102, 904) and the second channel (104, 906), wherein each of the series of apertures extends further along the longitudinal direction than along the first transverse direction and the second transverse direction, and is sized to selectively capture a biological source material capable of producing target biological substances; a first source connected to the first input (106, 922), the first source configured to selectively introduce into the first channel (102, 904) at least one first biological composition at a first channel flow rate; and a second source connected to the second input (110, 924), the second source configured to selectively introduce into the second channel (104, 906) at least one second biological composition at a second channel flow rate, wherein the first source and the second source are configured to control the first channel flow rate and the second channel flow rate to create a differential in the channels generating physiological shear rates sufficient to induce the biological source material captured to produce the target biological substances. a substrate (101, 902); a first channel (102, 904) formed in the substrate (101, 902), the first channel (102, 904) extending from a first input (106, 920) to a first output (106, 922) along a longitudinal direction, and extending along a first transverse direction; a second channel (104, 906) formed in the substrate (101, 902), the second channel (104, 906) extending from a second input (110, 924) to a second output (112, 926) along the longitudinal direction, and extending along the first transverse direction, wherein at least a portion of the first (102, 904) and second (104, 906) channels extend substantially parallel along the longitudinal direction; columns (114, 916) that separate the first channel (102, 904) and the second channel (104, 906) and extend along a second transverse direction; a series of apertures formed in between the columns (114, 916) proximal to a first portion of the substrate that create a fluid communication path between the first channel (102, 904) and the second channel (104, 906), wherein each of the series of apertures extends further along the longitudinal direction than along the first transverse direction and the second transverse direction, and is sized to selectively capture a biological source material capable of producing target biological substances; a first source connected to the first input (106, 922), the first source configured to selectively introduce into the first channel (102, 904) at least one first biological composition at a first channel flow rate; and a second source connected to the second input (110, 924), the second source configured to selectively introduce into the second channel (104, 906) at least one second biological composition at a second channel flow rate, wherein the first source and the second source are configured to control the first channel flow rate and the second channel flow rate to create a differential in the channels generating physiological shear rates sufficient to induce the biological source material captured to produce the target biological substances.