A catheter insertion device configured to inhibit release of a catheter hub of a catheter assembly from the catheter insertion device until a sharp distal tip of a needle cannula utilized to insert the catheter assembly is safely captured in a needle clip, the catheter insertion device comprising: a needle cannula having a sharp distal tip and a proximal end; a handle operably coupled to the proximal end of the needle cannula; and a safety clip assembly including a housing and a safety clip, the safety clip including first and second guard arms (148A, 148B) extending from a proximal wall, the first and second guard arms (148A, 148B) having respective first and second hook features (154A, 154B) configured to selectively grip the catheter hub of the catheter assembly and respective needle tip retention tabs (152A, 152B) having corresponding first and second apertures (156A, 156B) configured to enable passage of the needle cannula therethrough, wherein the safety clip assembly is configured to be in a first position in which the first and second guard arms (148A, 148B) are restrained against their natural bias by the passage of the needle cannula through the first and second apertures (156A, 156B) of the first and second retention tabs (152A, 152B) such that the first and second hook features (154A, 154B) extending from respective distal ends of guard arms (148A, 148B) are in gripping contact with the catheter hub; and wherein the safety clip assembly is configured to be in a second position in which the needle cannula is proximally withdrawn through the first and second apertures (156A, 156B) to enable the first and second guard arms (148A, 148B) to be naturally biased apart to release the catheter hub from the gripping contact by the first and second hook features (154A, 154B) and to return the retention tabs (152A, 152B) to their natural position to inhibit distal movement of the sharp distal tip of the needle cannula within the safety clip, characterised by the safety clip including two opposed safety clip retention tabs (133A, 133B) extending from sides of the proximal wall different from where the first and second guard arms (148A, 148B) extend from the proximal wall, the two opposed safety clip retention tabs (133A, 133B) configured to deflect when the safety clip is inserted into a chamber of the housing to enable the safety clip to be positioned at least partially within the housing and to provide an interference fit between one or more of the two opposed safety clip retention tabs (133A, 133B) and one or more of the walls defining the chamber of the housing to inhibit distal movement of the safety clip out of the housing. a needle cannula having a sharp distal tip and a proximal end; a handle operably coupled to the proximal end of the needle cannula; and a safety clip assembly including a housing and a safety clip, the safety clip including first and second guard arms (148A, 148B) extending from a proximal wall, the first and second guard arms (148A, 148B) having respective first and second hook features (154A, 154B) configured to selectively grip the catheter hub of the catheter assembly and respective needle tip retention tabs (152A, 152B) having corresponding first and second apertures (156A, 156B) configured to enable passage of the needle cannula therethrough, wherein the safety clip assembly is configured to be in a first position in which the first and second guard arms (148A, 148B) are restrained against their natural bias by the passage of the needle cannula through the first and second apertures (156A, 156B) of the first and second retention tabs (152A, 152B) such that the first and second hook features (154A, 154B) extending from respective distal ends of guard arms (148A, 148B) are in gripping contact with the catheter hub; and wherein the safety clip assembly is configured to be in a second position in which the needle cannula is proximally withdrawn through the first and second apertures (156A, 156B) to enable the first and second guard arms (148A, 148B) to be naturally biased apart to release the catheter hub from the gripping contact by the first and second hook features (154A, 154B) and to return the retention tabs (152A, 152B) to their natural position to inhibit distal movement of the sharp distal tip of the needle cannula within the safety clip, characterised by the safety clip including two opposed safety clip retention tabs (133A, 133B) extending from sides of the proximal wall different from where the first and second guard arms (148A, 148B) extend from the proximal wall, the two opposed safety clip retention tabs (133A, 133B) configured to deflect when the safety clip is inserted into a chamber of the housing to enable the safety clip to be positioned at least partially within the housing and to provide an interference fit between one or more of the two opposed safety clip retention tabs (133A, 133B) and one or more of the walls defining the chamber of the housing to inhibit distal movement of the safety clip out of the housing.