A system for extracorporeal blood temperature control, comprising: a heat exchanger for at least cooling a fluid contained in a circulation tank of the heat exchanger; a thermal exchange module having a first volume and a second volume fluidly isolated from one another; a fluid pump for circulating said fluid through said circulation tank of said heat exchanger and the first volume of the thermal exchange module, wherein operation of said fluid pump establishes a negative pressure within the first volume of said thermal exchange module and said fluid is drawn from the circulation tank through the first volume of said thermal exchange module; a blood pump for flowing blood through a first blood flow line, said second volume of said thermal exchange module, and a second blood flow line; and, a first controller for providing output signals for use in operation of at least said heat exchanger to selectively control thermal exchange between said fluid circulated through the first volume of the thermal exchange module and said blood flowed through the second volume of the thermal exchange module and thereby provide for at least selective cooling of the circulated blood, wherein the heat exchanger includes the circulation tank for receiving the circulated fluid from the fluid pump; a chiller tank; a mixing pump for pumping fluid from within the circulation tank into the chiller tank; a chiller pump and an evaporator/chiller, wherein upon operation of the chiller pump fluid is pumped from chiller tank through evaporator/chiller and back into chiller tank to yield cooling of fluid within the chiller tank. a heat exchanger for at least cooling a fluid contained in a circulation tank of the heat exchanger; a thermal exchange module having a first volume and a second volume fluidly isolated from one another; a fluid pump for circulating said fluid through said circulation tank of said heat exchanger and the first volume of the thermal exchange module, wherein operation of said fluid pump establishes a negative pressure within the first volume of said thermal exchange module and said fluid is drawn from the circulation tank through the first volume of said thermal exchange module; a blood pump for flowing blood through a first blood flow line, said second volume of said thermal exchange module, and a second blood flow line; and, a first controller for providing output signals for use in operation of at least said heat exchanger to selectively control thermal exchange between said fluid circulated through the first volume of the thermal exchange module and said blood flowed through the second volume of the thermal exchange module and thereby provide for at least selective cooling of the circulated blood, wherein the heat exchanger includes the circulation tank for receiving the circulated fluid from the fluid pump; a chiller tank; a mixing pump for pumping fluid from within the circulation tank into the chiller tank; a chiller pump and an evaporator/chiller, wherein upon operation of the chiller pump fluid is pumped from chiller tank through evaporator/chiller and back into chiller tank to yield cooling of fluid within the chiller tank. the circulation tank for receiving the circulated fluid from the fluid pump; a chiller tank; a mixing pump for pumping fluid from within the circulation tank into the chiller tank; a chiller pump and an evaporator/chiller, wherein upon operation of the chiller pump fluid is pumped from chiller tank through evaporator/chiller and back into chiller tank to yield cooling of fluid within the chiller tank.