A single needle integrated artificial pancreas, comprising: a fluid reservoir unit configured to store insulin; a fluid driving unit connected to the fluid reservoir unit and configured to deliver the insulin stored in the fluid reservoir unit to the subcutaneous tissue of a patient; an indwelling unit connected to the fluid reservoir unit, comprising a glucose sensor, an indwelling cannula, a groove puncture needle and an inserter, wherein the glucose sensor is an electrode sensor comprising an enzyme layer, and configured to monitor in real time a change of glucose and produce effective glucose signals based on the change of the glucose; and a glucose monitoring and insulin delivery control unit, which is connected to the fluid reservoir unit, the fluid driving unit and the indwelling unit, and configured to process the effective glucose signals output by the glucose sensor, and to control the fluid reservoir unit, the fluid driving unit and the indwelling unit; wherein the electrode sensor and the indwelling cannula are simultaneously implanted in a same subcutaneous tissue in the patient via the inserter with the aid of the groove puncture needle; characterized in that the single needle integrated artificial pancreas further comprises a skin temperature automatic adjusting device configured to heat the skin tissue where the electrode sensor and the indwelling cannula are implanted; wherein the electrode sensor together with the indwelling cannula is located in a groove of the groove puncture needle; wherein a distance between an end of the indwelling cannula and an end of the electrode sensor ranges from 1mm to 8mm. a fluid reservoir unit configured to store insulin; a fluid driving unit connected to the fluid reservoir unit and configured to deliver the insulin stored in the fluid reservoir unit to the subcutaneous tissue of a patient; an indwelling unit connected to the fluid reservoir unit, comprising a glucose sensor, an indwelling cannula, a groove puncture needle and an inserter, wherein the glucose sensor is an electrode sensor comprising an enzyme layer, and configured to monitor in real time a change of glucose and produce effective glucose signals based on the change of the glucose; and a glucose monitoring and insulin delivery control unit, which is connected to the fluid reservoir unit, the fluid driving unit and the indwelling unit, and configured to process the effective glucose signals output by the glucose sensor, and to control the fluid reservoir unit, the fluid driving unit and the indwelling unit; wherein the electrode sensor and the indwelling cannula are simultaneously implanted in a same subcutaneous tissue in the patient via the inserter with the aid of the groove puncture needle; characterized in that the single needle integrated artificial pancreas further comprises a skin temperature automatic adjusting device configured to heat the skin tissue where the electrode sensor and the indwelling cannula are implanted; wherein the electrode sensor together with the indwelling cannula is located in a groove of the groove puncture needle; wherein a distance between an end of the indwelling cannula and an end of the electrode sensor ranges from 1mm to 8mm.