mhurhangee/ep-ind-claims huggingface dataset:
A method for identifying a chemical compound or agent able to induce ubiquitination of a protein of interest, the method comprising: (i) contacting a chemical compound or agent of interest with an isolated eukaryotic cell comprising and/or expressing the protein of interest and manipulating said cell to comprise enhanced cullin-RING ubiquitin ligase activity; (ii) determining the level of at least one member of an E3 ligase complex present in the cell; wherein said chemical compound or agent is identified to induce ubiquitination of the protein of interest if the level of the at least one member of the E3 ligase complex is increased compared to the level determined in the absence of said chemical compound or agent of interest. the method comprising: (i) contacting a chemical compound or agent of interest with an isolated eukaryotic cell comprising and/or expressing the protein of interest and manipulating said cell to comprise enhanced cullin-RING ubiquitin ligase activity; (ii) determining the level of at least one member of an E3 ligase complex present in the cell; (i) contacting a chemical compound or agent of interest with an isolated eukaryotic cell comprising and/or expressing the protein of interest and manipulating said cell to comprise enhanced cullin-RING ubiquitin ligase activity; (ii) determining the level of at least one member of an E3 ligase complex present in the cell; wherein said chemical compound or agent is identified to induce ubiquitination of the protein of interest if the level of the at least one member of the E3 ligase complex is increased compared to the level determined in the absence of said chemical compound or agent of interest.
A turbine shroud sector made of ceramic matrix composite intended to extend about a longitudinal axis X, the shroud sector comprising a base with a radially internal face, a radially external face from which there extend an upstream tab and a downstream tab for attachment to a shroud support structure, and at least one inter-sector lateral face intended to be mounted opposite a lateral face of a circumferentially adjacent shroud sector, the base further comprising a first groove and a second groove each formed in the inter-sector lateral face, extending along the longitudinal axis X and, a first and a second longitudinal sealing strips (14, 17) which each rest on a respective radially internal wall of these first and second grooves (10, 16), the second groove being arranged radially outside the first groove, characterised in that the first strip has an overall shape of an omega and in that the shroud sector has a first clearance which is defined radially between a central part of the first strip and the radially internal wall of the first groove and a second clearance which is defined radially between the central part of the first strip and a radially external wall of the first groove, the radially internal and external walls (15a, 15b) being opposite along a radial axis Z perpendicular to the longitudinal axis X.
A device for determining the sensitivity of microorganisms to antimicrobial drugs configured in the form of a sterile plate made from plastic material with indentations provided with a sealing element that covers the plate characterized in that the indentations are filled with a solid culture medium containing agar; wherein the culture medium in different indentations contains different antimicrobial drugs or combinations thereof or serves as a control; between the plate and the sealing element a moisture-absorbing material is placed, under the moisture-absorbing material a rigid mesh made of plastic is placed; the device is equipped with a transparent protective lid made of a rigid durable plastic.
A cutting tool, comprising: a cutting insert comprising a body part of polygonal plate shape, a cutting edge located along an intersection of an upper surface and a side surface of the body part; and a holder comprising an insert pocket for attaching the cutting insert at a front end part of the holder, wherein the insert pocket comprises a seating part comprising a seating face which is brought into contact with a lower surface of the cutting insert, and is inclined forward in a rotation direction of the holder as the seating face extends away from the front end part of the holder, and a constraining part configured to be brought into contact with a first side surface and a second side surface adjacent to each other among the side surface of the cutting insert, the constraining part comprises a curved portion and a first constraining face which is connected to one end of the curved portion, characterized in that the first constraining face extends away from the front end part of the holder as the first constraining face extends away from the curved portion, wherein the constraining part further comprises a second constraining face which is connected to the other end of the curved portion, extends toward the front end part of the holder as the second constraining face extends away from the curved portion and extends toward a rotation axis of the holder from an end portion close to the curved portion. a cutting insert comprising a body part of polygonal plate shape, a cutting edge located along an intersection of an upper surface and a side surface of the body part; and a holder comprising an insert pocket for attaching the cutting insert at a front end part of the holder, wherein the insert pocket comprises a seating part comprising a seating face which is brought into contact with a lower surface of the cutting insert, and is inclined forward in a rotation direction of the holder as the seating face extends away from the front end part of the holder, and a constraining part configured to be brought into contact with a first side surface and a second side surface adjacent to each other among the side surface of the cutting insert, a seating part comprising a seating face which is brought into contact with a lower surface of the cutting insert, and is inclined forward in a rotation direction of the holder as the seating face extends away from the front end part of the holder, and a constraining part configured to be brought into contact with a first side surface and a second side surface adjacent to each other among the side surface of the cutting insert, the constraining part comprises a curved portion and a first constraining face which is connected to one end of the curved portion, a curved portion and a first constraining face which is connected to one end of the curved portion,
An apparatus arranged to break an electrical current, the apparatus comprising: a mechanical switch leg comprising a first winding of a mutual inductor and a mechanical switch connected in series; a semiconductor switch leg comprising a second winding of the mutual inductor and a semiconductor switch connected in series; and an overvoltage protection circuit; wherein the mechanical switch leg and the semiconductor switch leg are connected in parallel and a self inductance of the second winding is lower than a self inductance of the first winding. a mechanical switch leg comprising a first winding of a mutual inductor and a mechanical switch connected in series; a semiconductor switch leg comprising a second winding of the mutual inductor and a semiconductor switch connected in series; and an overvoltage protection circuit; wherein the mechanical switch leg and the semiconductor switch leg are connected in parallel and a self inductance of the second winding is lower than a self inductance of the first winding.
Radiation-emitting semiconductor component, the semiconductor body of which is formed by a stack of different III-V nitride semiconductor layers and which has a first main surface and a second main surface, wherein at least part of the radiation generated is coupled out through the first main surface, wherein - a reflector is applied to the second main surface, - the semiconductor layers are based on GaN, - the semiconductor layers together with the reflector are applied to a carrier, - the semiconductor layers are free of a growth substrate, and - the semiconductor layers have a contact pad at their surface facing away from the carrier, characterized in that - a contact layer is applied to the second main surface, - a passivation layer is applied to the semiconductor layers, said passivation layer covering the contact layer in places, - a bond solder is deposited onto the regions of the contact layer which are not covered by the passivation layer, - the reflector is deposited onto the bond solder, wherein the reflector consists of a silver alloy or of an aluminium alloy, and - the semiconductor layers together with the reflector are eutectically bonded onto the carrier. - a reflector is applied to the second main surface, - the semiconductor layers are based on GaN, - the semiconductor layers together with the reflector are applied to a carrier, - the semiconductor layers are free of a growth substrate, and - the semiconductor layers have a contact pad at their surface facing away from the carrier, - a contact layer is applied to the second main surface, - a passivation layer is applied to the semiconductor layers, said passivation layer covering the contact layer in places, - a bond solder is deposited onto the regions of the contact layer which are not covered by the passivation layer, - the reflector is deposited onto the bond solder, wherein the reflector consists of a silver alloy or of an aluminium alloy, and - the semiconductor layers together with the reflector are eutectically bonded onto the carrier.
A pump assembly with an electric motor which comprises a stator housing and an electronics housing fastened at the outside on the stator housing, wherein the stator housing comprises a recess extending transversely to the joining direction, in which the electronics housing is applied onto the stator housing, the electronics housing comprises a guide and that a locking slide engages through the guide and the recess, characterised in that the locking slide, when it is inserted into the guide and the recess, is movable between a released position and a locked position, wherein the recess and the locking slide are arranged such, that a movement of the electronics housing in joining direction relative to the stator housing is caused by movement of the locking slide into the locking position.
Climate chamber, comprising - a housing, comprising at least one door, having an inner chamber which can be closed by means of the at least one door, - wherein the at least one door comprises an inner wall and an outer wall, - wherein the inner wall is formed from a single-piece, flexible basic body which comprises a polygonal wall section surrounded by lateral regions, characterized in that - one free end of a tab protrudes from each of the lateral regions, - wherein a first edge of the tab is folded from the wall section into a first section in order to form a basin, - wherein the free end of the tab is folded back through a second edge into a second section in order to form a sealing holder, into which a sealing can be inserted, and - wherein the basin is arranged on the side facing an outer side in order to receive one or more thermally insulating layers and the sealing holder is arranged on a side facing the inner side for the sealing of the door. - a housing, comprising at least one door, having an inner chamber which can be closed by means of the at least one door, - wherein the at least one door comprises an inner wall and an outer wall, - wherein the inner wall is formed from a single-piece, flexible basic body which comprises a polygonal wall section surrounded by lateral regions, - one free end of a tab protrudes from each of the lateral regions, - wherein a first edge of the tab is folded from the wall section into a first section in order to form a basin, - wherein the free end of the tab is folded back through a second edge into a second section in order to form a sealing holder, into which a sealing can be inserted, and - wherein the basin is arranged on the side facing an outer side in order to receive one or more thermally insulating layers and the sealing holder is arranged on a side facing the inner side for the sealing of the door.
Healing earth preparation containing 90 - 99.9 % by weight of healing earth and 0.1 - 10 % by weight of binder, wherein the binder comprises one or more water-soluble polymers, wherein each water-soluble polymer of the binder is selected from the group consisting of starch, tragacanth or cellulose acetate, cellulose ether, ethyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose and polyvinyl alcohol, wherein the healing earth preparation is coated with a coating in an amount of 1.5 to 5.0 % by weight based on the total weight of the coated preparation, wherein the coating comprises one or more water soluble polymers or film formers, and wherein each water soluble film former or soluble polymer of the coating is selected from the group consisting of starch, modified starch, sucrose, cellulose acetate, ethylcellulose, methylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, maltodextrin, gum arabic the preparation being in the form of coated granules.
A method for leaching a material from an object, comprising: exposing said material to a liquid leaching agent in a vessel; heating the leaching agent; reducing a first pressure in an accumulator to less than a second pressure in the vessel with the heated leaching agent; performing a boiling cycle by venting the vessel to the accumula tor to superheat and boil the leaching agent; sensing a control parameter associated with boiling of the leaching agent; and varying the first pressure in the accumulator based on the sensed control parameter to control an amount of boiling of the leaching agent, wherein the control parameter is a plurality of control parameters, including an acoustic noise indicative of boiling of the leaching agent and including a duration of boiling determined based on the acoustic noise. exposing said material to a liquid leaching agent in a vessel; heating the leaching agent; reducing a first pressure in an accumulator to less than a second pressure in the vessel with the heated leaching agent; performing a boiling cycle by venting the vessel to the accumula tor to superheat and boil the leaching agent; sensing a control parameter associated with boiling of the leaching agent; and varying the first pressure in the accumulator based on the sensed control parameter to control an amount of boiling of the leaching agent, wherein the control parameter is a plurality of control parameters, including an acoustic noise indicative of boiling of the leaching agent and including a duration of boiling determined based on the acoustic noise.
A vibration damping material suitable for use in a wearable garment, comprising a sheet of a flexible material with a first and a second side (11, 12), characterised by both comprising a plurality of protrusions (20; 30) arranged in a predetermined pattern, wherein the protrusions (20; 30) on the first and/or second side (11, 12) of the sheet are arranged to be equidistant from adjacent protrusions (20; 30), wherein the protrusions (20; 30) are distributed in a substantially uniform pattern throughout the first and/or second side (11, 12) of the sheet of flexible material, wherein the protrusions (20; 30) on the first side of the sheet are arranged to be offset with respect to the protrusions (20; 30) on the second side of the sheet of flexible material. both comprising a plurality of protrusions (20; 30) arranged in a predetermined pattern, wherein the protrusions (20; 30) on the first and/or second side (11, 12) of the sheet are arranged to be equidistant from adjacent protrusions (20; 30), wherein the protrusions (20; 30) are distributed in a substantially uniform pattern throughout the first and/or second side (11, 12) of the sheet of flexible material, wherein the protrusions (20; 30) on the first side of the sheet are arranged to be offset with respect to the protrusions (20; 30) on the second side of the sheet of flexible material.
An impact sensor comprising: an elongate body having a first end, a second end, and a central longitudinal axis extending between the first end and the second end; a first dye cavity at the first end, the first dye cavity having a first dye disposed therein; a second dye cavity at the second end, the second dye cavity having a second dye disposed therein; an elongate cavity extending along the central longitudinal axis between the first dye cavity and the second dye cavity; a first opening providing fluid communication between the first dye cavity and the elongate cavity; a second opening providing fluid communication between the second dye cavity and the elongate cavity; characterised in that the impact sensor further comprises: a first sealing member releasably disposed in the first opening and comprising a ball; a second sealing member releasably disposed in the second opening and comprising a ball; and a biasing member comprising a helical spring and having a first end biasing the first sealing member in the first opening and a second end biasing the second sealing member in the second opening. an elongate body having a first end, a second end, and a central longitudinal axis extending between the first end and the second end; a first dye cavity at the first end, the first dye cavity having a first dye disposed therein; a second dye cavity at the second end, the second dye cavity having a second dye disposed therein; an elongate cavity extending along the central longitudinal axis between the first dye cavity and the second dye cavity; a first opening providing fluid communication between the first dye cavity and the elongate cavity; a second opening providing fluid communication between the second dye cavity and the elongate cavity; a first sealing member releasably disposed in the first opening and comprising a ball; a second sealing member releasably disposed in the second opening and comprising a ball; and a biasing member comprising a helical spring and having a first end biasing the first sealing member in the first opening and a second end biasing the second sealing member in the second opening.
A fulvestrant-containing composition comprising: a) fulvestrant at a concentration of from 50 mg/ml to 150 mg/ml; b) a solvent selected from the group consisting of dimethyl sulfoxide (DMSO), glycofurol, N-methyl pyrrolidone, and mixtures thereof; c) an oil mixture of caprylic and capric triglycerides; and d) a sustained release member selected from the group consisting of benzyl benzoate and benzyl alcohol; wherein said fulvestrant-containing composition having less than 5% total impurities, on a normalized peak area response ("PAR") basis as determined by high performance liquid chromatography ("HPLC") at a wavelength of 223nm, after at least 24 months of storage at temperatures of from 5°C to 25°C includes not more than 5% of castor oil and castor oil derivatives; wherein the volume ratio of solvent: oil mixture: sustained release member is 1-2.5: 0.9-2.5: 0.9-2.5. a) fulvestrant at a concentration of from 50 mg/ml to 150 mg/ml; b) a solvent selected from the group consisting of dimethyl sulfoxide (DMSO), glycofurol, N-methyl pyrrolidone, and mixtures thereof; c) an oil mixture of caprylic and capric triglycerides; and d) a sustained release member selected from the group consisting of benzyl benzoate and benzyl alcohol; wherein said fulvestrant-containing composition having less than 5% total impurities, on a normalized peak area response ("PAR") basis as determined by high performance liquid chromatography ("HPLC") at a wavelength of 223nm, after at least 24 months of storage at temperatures of from 5°C to 25°C includes not more than 5% of castor oil and castor oil derivatives; wherein the volume ratio of solvent: oil mixture: sustained release member is 1-2.5: 0.9-2.5: 0.9-2.5.
A motion control system for reducing jitter between control events, comprising: at least one drive device programmed or configured to: receive a data signal associated with a time base of a controller device in the motion control system; determine a frequency of the time base of the controller device based on the data signal associated with the time base of the controller device; determine a frequency adjustment to be made to a time base of the at least one drive device based on the frequency of the time base of the controller device; adjust a frequency of the time base of the at least one drive device based on the frequency adjustment; provide a data signal associated with the time base of the at least one drive device; and execute a control event based on the frequency of the time base of the at least one drive device. receive a data signal associated with a time base of a controller device in the motion control system; determine a frequency of the time base of the controller device based on the data signal associated with the time base of the controller device; determine a frequency adjustment to be made to a time base of the at least one drive device based on the frequency of the time base of the controller device; adjust a frequency of the time base of the at least one drive device based on the frequency adjustment; provide a data signal associated with the time base of the at least one drive device; and execute a control event based on the frequency of the time base of the at least one drive device.
Method for controlling and/or preventing a fire in a vehicle air-conditioning system containing 2,3,3,3-tetrafluoro-1-propene as refrigerant, characterized in that at least the constituents of the air-conditioning system which contain the refrigerant are brought into contact with an extinguishant which contains an aqueous solution or suspension of a calcium-containing compound and of a gel-forming extinguishant additive, wherein a weight fraction of gel-forming extinguishant additive per volume of extinguishant is in the range from 0.1 to 3.0% w/v.
An aqueous, propellant gas-free preparation containing epinephrine or an epinephrine salt, ester or hydrate, characterised in that it comprises a stabilising addition selected from citric acid and/or citric acid salt and/or ethylenediaminetetraacetic acid or a salt thereof, in combination with ethanol.
A method for stabilizing a guayule rubber comprising the step of introducing 4-(mercapto acetamido)diphenyl amine (MADA) to a latex form of the rubber under conditions such that the MADA becomes chemically bound to the rubber, a second step of coagulating the rubber, and a subsequent step of treating said rubber to remove at least a substantial portion of entrained resins to give a rubber including less than 4% by weight resins.