A system configured for irreversible electroporation ablation energy delivery comprising a pulse waveform generator; and an ablation device coupled to the pulse waveform generator, the ablation device including at least one electrode (603 - 606, 609 - 612) configured for irreversible electroporation ablation energy delivery to tissue during use, wherein the pulse waveform generator is configured to deliver voltage pulses to the ablation device in the form of a pulsed waveform, wherein: (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay, characterised in that the pulse waveform generator is further configured to deliver each second set of pulses from the plurality of pulses over a heartbeat such that the plurality of second sets of pulses is deliverable over a series of heartbeats. a pulse waveform generator; and an ablation device coupled to the pulse waveform generator, the ablation device including at least one electrode (603 - 606, 609 - 612) configured for irreversible electroporation ablation energy delivery to tissue during use, wherein the pulse waveform generator is configured to deliver voltage pulses to the ablation device in the form of a pulsed waveform, wherein: (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay, characterised in that the pulse waveform generator is further configured to deliver each second set of pulses from the plurality of pulses over a heartbeat such that the plurality of second sets of pulses is deliverable over a series of heartbeats. (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay,