A compound of Formula: wherein: X is C-R a; R 1 and R 2 each are hydrogen, (C 1-6)alkyl, or (CH 2)p-C OR b; R 3 and R 4 each are hydrogen, OH or OR c; wherein: R a is hydrogen or halogen; R b or R c each is H, (C 1-6)-alkyl, an alkali metal or negative charge; A is selected from: wherein: R 6, R 7, R 8, R 9, R 10, R 11 or R 12, R 13, R 14, R 15, R 16, R 17, R 18, R 19, R 20, R 21, R 22, or R 23 is H, straight or branched(C 1-6)-alkyl or C 3-6 -cycloalkyl; each A optionally further is substituted by one or more of the following substituents selected from -H, -OH, Oxo (=O), -CN, -NO 2, -halogen, - straight or branched C 1-6 alkyl,- straight or branched C 1-6 haloalkyl, C 3-6 -cycloalkyl, - straight or branched C 1-6 alkoxy, -OC OH, -OC R e, -C OR f, -O(CH 2) y OR 9, -NR h R i, - SO 2 R j, -S(CH 2)qR k,-NR l C R m, aryl or heteroaryl; where: each R e, R f, R g, R h, R i, R j, R k, R l,or R m as defined above is selected from H, C 1-6 alkyl, C 1-6 haloalkyl, or C 1-6 alkoxy; each aryl or heteroaryl as defined above is optionally substituted with one or more of the following substituents selected from H, -OH, -CN, - NO 2,-halogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy, -OC OH,-OC R n, -C OR o, -O(CH 2) y OR p, -NR q R r, -SO 2 R s, -S(CH 2) y -R t, - NR u C R v; where: R n, R o, R p, R q, R r, R s, R t, R u, or R v each as defined above are selected from C 1-6 alkyl, C 1-6 -haloalkyl, or C 1-6 -alkoxy; and n, m, o, p, q or y each are 0 or an integer from 1 to 5; or a pharmaceutically acceptable salt thereof. X is C-R a; R 1 and R 2 each are hydrogen, (C 1-6)alkyl, or (CH 2)p-C OR b; R 3 and R 4 each are hydrogen, OH or OR c; wherein: R a is hydrogen or halogen; R b or R c each is H, (C 1-6)-alkyl, an alkali metal or negative charge; R a is hydrogen or halogen; R b or R c each is H, (C 1-6)-alkyl, an alkali metal or negative charge; A is selected from: wherein: R 6, R 7, R 8, R 9, R 10, R 11 or R 12, R 13, R 14, R 15, R 16, R 17, R 18, R 19, R 20, R 21, R 22, or R 23 is H, straight or branched(C 1-6)-alkyl or C 3-6 -cycloalkyl; each A optionally further is substituted by one or more of the following substituents selected from -H, -OH, Oxo (=O), -CN, -NO 2, -halogen, - straight or branched C 1-6 alkyl,- straight or branched C 1-6 haloalkyl, C 3-6 -cycloalkyl, - straight or branched C 1-6 alkoxy, -OC OH, -OC R e, -C OR f, -O(CH 2) y OR 9, -NR h R i, - SO 2 R j, -S(CH 2)qR k,-NR l C R m, aryl or heteroaryl; where: each R e, R f, R g, R h, R i, R j, R k, R l,or R m as defined above is selected from H, C 1-6 alkyl, C 1-6 haloalkyl, or C 1-6 alkoxy; each aryl or heteroaryl as defined above is optionally substituted with one or more of the following substituents selected from H, -OH, -CN, - NO 2,-halogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy, -OC OH,-OC R n, -C OR o, -O(CH 2) y OR p, -NR q R r, -SO 2 R s, -S(CH 2) y -R t, - NR u C R v; where: R n, R o, R p, R q, R r, R s, R t, R u, or R v each as defined above are selected from C 1-6 alkyl, C 1-6 -haloalkyl, or C 1-6 -alkoxy; and R 6, R 7, R 8, R 9, R 10, R 11 or R 12, R 13, R 14, R 15, R 16, R 17, R 18, R 19, R 20, R 21, R 22, or R 23 is H, straight or branched(C 1-6)-alkyl or C 3-6 -cycloalkyl; each A optionally further is substituted by one or more of the following substituents selected from -H, -OH, Oxo (=O), -CN, -NO 2, -halogen, - straight or branched C 1-6 alkyl,- straight or branched C 1-6 haloalkyl, C 3-6 -cycloalkyl, - straight or branched C 1-6 alkoxy, -OC OH, -OC R e, -C OR f, -O(CH 2) y OR 9, -NR h R i, - SO 2 R j, -S(CH 2)qR k,-NR l C R m, aryl or heteroaryl; where: each R e, R f, R g, R h, R i, R j, R k, R l,or R m as defined above is selected from H, C 1-6 alkyl, C 1-6 haloalkyl, or C 1-6 alkoxy; each aryl or heteroaryl as defined above is optionally substituted with one or more of the following substituents selected from H, -OH, -CN, - NO 2,-halogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy, -OC OH,-OC R n, -C OR o, -O(CH 2) y OR p, -NR q R r, -SO 2 R s, -S(CH 2) y -R t, - NR u C R v; where: R n, R o, R p, R q, R r, R s, R t, R u, or R v each as defined above are selected from C 1-6 alkyl, C 1-6 -haloalkyl, or C 1-6 -alkoxy; and each R e, R f, R g, R h, R i, R j, R k, R l,or R m as defined above is selected from H, C 1-6 alkyl, C 1-6 haloalkyl, or C 1-6 alkoxy; each aryl or heteroaryl as defined above is optionally substituted with one or more of the following substituents selected from H, -OH, -CN, - NO 2,-halogen, C 1-6 -alkyl, C 1-6 -haloalkyl, C 1-6 -alkoxy, -OC OH,-OC R n, -C OR o, -O(CH 2) y OR p, -NR q R r, -SO 2 R s, -S(CH 2) y -R t, - NR u C R v; where: R n, R o, R p, R q, R r, R s, R t, R u, or R v each as defined above are selected from C 1-6 alkyl, C 1-6 -haloalkyl, or C 1-6 -alkoxy; and R n, R o, R p, R q, R r, R s, R t, R u, or R v each as defined above are selected from C 1-6 alkyl, C 1-6 -haloalkyl, or C 1-6 -alkoxy; and n, m, o, p, q or y each are 0 or an integer from 1 to 5; or a pharmaceutically acceptable salt thereof.