A compound of formula: or a pharmaceutically-acceptable salt, solvate or hydrate thereof, wherein Z is selected from, CF 3, C 1 -C 3 alkoxy, CF 3 O, halogen, cyano and C 1 -C 4 alkyl optionally substituted with one or more halogens; Y is selected from halogen, C 1 -C 3 alkoxy, hydroxyl, CF 3 O and cyano; W is selected from oxygen, sulfur and two hydrogens; R 3 and R 4 are independently selected from C 1 -C 4 alkyl optionally substituted with one or more fluoro or hydroxyl groups, or R 3 and R 4 and the carbon to which they are attached together form a 3-6 membered cycloalkyl ring, wherein one or more carbons may be optionally substituted with one or more fluoro or hydroxyl groups, and wherein one of the carbons is optionally an oxygen or nitrogen; A 1 is an aryl group or heteroaryl group optionally substituted with one or more C 1 -C 4 alkyl, cyano, hydroxyl, methoxy, ethoxyl, halogen or a 5-6 membered heteroaryl group; A 2 is (CF 2) a m Y 1 (CH 2) n Q wherein a, m and n are integers independently selected from 0 to 4 and wherein at least one of a or m or n is not zero, or A 2 is (CH 2) m Y 1 (CH 2) n Q wherein m and n are integers independently selected from 0 to 4 and wherein at least one of m or n is not zero; Q is selected from C NHR", C(R x R y)C NR"R 1 ", SO 2 R", SO 2 NR"R 1 ", cyano, hydroxyl, C 1 -C 3 alkoxy, C NR"R 1 ", C OR", OC NR"R 1 ", C NR"R 1 ", 5-6 membered heteroaryl optionally substituted with hydroxyl, C 1 -C 3 alkoxy, C 1 -C 6 alkyl, halogen or cyano, and a 4-6 membered heterocycle optionally susbstituted with hydroxyl, C 1 -C 3 alkoxy, C 1 -C 6 alkyl, halogen or cyano; and Y 1 is selected from direct bond, -O-, -S-, and -NR"-; R" and R 1 " are independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl and C 1 -C 6 alkenyl, or NR"R 1 " together form a 3-7 membered heterocyclic ring wherein one or more carbons may be optionally substituted with one or more hydroxyl, amino, cyano or fluoro groups; R x and R y are independently selected from hydrogen or methyl; or C(R x R y) together form a 3-5 membered cyclic alkyl ring optionally substituted with one or more hydroxyl, amino, cyano or fluoro groups or a 3-5 membered cyclic ring wherein one carbon is replaced with an oxygen or an amine. wherein Z is selected from, CF 3, C 1 -C 3 alkoxy, CF 3 O, halogen, cyano and C 1 -C 4 alkyl optionally substituted with one or more halogens; Y is selected from halogen, C 1 -C 3 alkoxy, hydroxyl, CF 3 O and cyano; W is selected from oxygen, sulfur and two hydrogens; R 3 and R 4 are independently selected from C 1 -C 4 alkyl optionally substituted with one or more fluoro or hydroxyl groups, or R 3 and R 4 and the carbon to which they are attached together form a 3-6 membered cycloalkyl ring, wherein one or more carbons may be optionally substituted with one or more fluoro or hydroxyl groups, and wherein one of the carbons is optionally an oxygen or nitrogen; A 1 is an aryl group or heteroaryl group optionally substituted with one or more C 1 -C 4 alkyl, cyano, hydroxyl, methoxy, ethoxyl, halogen or a 5-6 membered heteroaryl group; A 2 is (CF 2) a m Y 1 (CH 2) n Q wherein a, m and n are integers independently selected from 0 to 4 and wherein at least one of a or m or n is not zero, or A 2 is (CH 2) m Y 1 (CH 2) n Q wherein m and n are integers independently selected from 0 to 4 and wherein at least one of m or n is not zero; Q is selected from C NHR", C(R x R y)C NR"R 1 ", SO 2 R", SO 2 NR"R 1 ", cyano, hydroxyl, C 1 -C 3 alkoxy, C NR"R 1 ", C OR", OC NR"R 1 ", C NR"R 1 ", 5-6 membered heteroaryl optionally substituted with hydroxyl, C 1 -C 3 alkoxy, C 1 -C 6 alkyl, halogen or cyano, and a 4-6 membered heterocycle optionally susbstituted with hydroxyl, C 1 -C 3 alkoxy, C 1 -C 6 alkyl, halogen or cyano; and Y 1 is selected from direct bond, -O-, -S-, and -NR"-; R" and R 1 " are independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl and C 1 -C 6 alkenyl, or NR"R 1 " together form a 3-7 membered heterocyclic ring wherein one or more carbons may be optionally substituted with one or more hydroxyl, amino, cyano or fluoro groups; R x and R y are independently selected from hydrogen or methyl; or C(R x R y) together form a 3-5 membered cyclic alkyl ring optionally substituted with one or more hydroxyl, amino, cyano or fluoro groups or a 3-5 membered cyclic ring wherein one carbon is replaced with an oxygen or an amine.