mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition comprising guanfacine or a salt thereof and at least one non pH-dependent sustained release agent, wherein guanfacine or a salt thereof is incorporated in nanoparticles having a size of from 70 - 1,000 nm and having a polydispersity index of ≤ 0.5, and wherein guanfacine or a salt thereof is present in complex form, where the nanoparticles are obtainable by a method comprising the steps of: a) providing a fluid mixture of guanfacine or a salt thereof with a solvent; and a fluid non-solvent; b) precipitating nanoparticles containing guanfacine or a salt thereof by colliding fluid streams of the fluid mixture and the non-solvent; and c) isolating the nanoparticles as a nanoparticle suspension. a) providing a fluid mixture of guanfacine or a salt thereof with a solvent; and a fluid non-solvent; b) precipitating nanoparticles containing guanfacine or a salt thereof by colliding fluid streams of the fluid mixture and the non-solvent; and c) isolating the nanoparticles as a nanoparticle suspension.
A bird's-eye view video generation device comprising: a video data acquisition unit configured to acquire video data from a plurality of cameras (11, 12, 13, 14) configured to capture videos of surroundings of a vehicle; a bird's-eye view video generator configured to generate a bird's-eye view video from a virtual viewpoint above the vehicle by performing viewpoint conversion processing on the video data acquired by the video data acquisition unit to synthesize the viewpoint-converted videos (101, 102, 103, 104); an obstacle information acquisition unit configured to acquire information from at least one detector configured to detect at least one obstacle (Q, Q1, Q2) around the vehicle and to specify a position of the detected obstacle (Q, Q1, Q2) on the bird's-eye view video; and a display controller configured to display the bird's-eye view video in a display, characterized in that, when the position of the obstacle (Q, Q1, Q2) that is specified by the obstacle information acquisition unit overlaps a synthesis boundary (B, B1, B2, B3, B4) between the videos (101, 102, 103, 104) in the bird's-eye view video, the bird's-eye view video generator is further configured to generate a bird's-eye view video (100A, 100B, 100C) obtained by changing the position of the virtual viewpoint of the bird's-eye view video to a position (PA, PB, PC) from which the obstacle (Q, Q1, Q2) does not overlap the synthesis boundary (B1A, B2A, B3A, B4A; B1B B2B, B3B, B4B; B1C, B2C, B3C, B4C) in the bird's-eye view video (100A, 100B, 100C). a video data acquisition unit configured to acquire video data from a plurality of cameras (11, 12, 13, 14) configured to capture videos of surroundings of a vehicle; a bird's-eye view video generator configured to generate a bird's-eye view video from a virtual viewpoint above the vehicle by performing viewpoint conversion processing on the video data acquired by the video data acquisition unit to synthesize the viewpoint-converted videos (101, 102, 103, 104); an obstacle information acquisition unit configured to acquire information from at least one detector configured to detect at least one obstacle (Q, Q1, Q2) around the vehicle and to specify a position of the detected obstacle (Q, Q1, Q2) on the bird's-eye view video; and a display controller configured to display the bird's-eye view video in a display, characterized in that, when the position of the obstacle (Q, Q1, Q2) that is specified by the obstacle information acquisition unit overlaps a synthesis boundary (B, B1, B2, B3, B4) between the videos (101, 102, 103, 104) in the bird's-eye view video, the bird's-eye view video generator is further configured to generate a bird's-eye view video (100A, 100B, 100C) obtained by changing the position of the virtual viewpoint of the bird's-eye view video to a position (PA, PB, PC) from which the obstacle (Q, Q1, Q2) does not overlap the synthesis boundary (B1A, B2A, B3A, B4A; B1B B2B, B3B, B4B; B1C, B2C, B3C, B4C) in the bird's-eye view video (100A, 100B, 100C).
A process for preparation of a compound of Formula: a pharmaceutically acceptable salt thereof, wherein: R 1 is BH 3 or a lone electron pair; and R 2 is hydrogen or methyl, which comprises steps of: treating 2-chloropyridine, 2-fluoropyridine or 2-bromopyridine with 3-aminopropanol to form a compound having formula: at elevated temperatures from about 100 °C to about 160 °C under N 2 atmosphere; converting the compound formed in step to a compound having formula: by adding thionyl bromide, SOBr 2, at temperatures of about < 15°C to form an intermediate by adding successive tertiary amines selected from di-isoproplyethyl amine, tri-ethyl amine or 1,8-Diazabicyclo[5.4.0]undec-7-ene; followed by adding of borane reagents selected from borane dimethylsulfide (BH 3 -SMe 2), diborane or borane tetrahydrofuran at temperatures from about -20°C to about -70°C; reacting the compound formed in step with a compound having formula: to form a compound of Formula. treating 2-chloropyridine, 2-fluoropyridine or 2-bromopyridine with 3-aminopropanol to form a compound having formula: at elevated temperatures from about 100 °C to about 160 °C under N 2 atmosphere; converting the compound formed in step to a compound having formula: by adding thionyl bromide, SOBr 2, at temperatures of about < 15°C to form an intermediate by adding successive tertiary amines selected from di-isoproplyethyl amine, tri-ethyl amine or 1,8-Diazabicyclo[5.4.0]undec-7-ene; followed by adding of borane reagents selected from borane dimethylsulfide (BH 3 -SMe 2), diborane or borane tetrahydrofuran at temperatures from about -20°C to about -70°C; reacting the compound formed in step with a compound having formula: to form a compound of Formula.
Closing device for a container for fluids, characterized in that it comprises: - a valve unit comprising a passage aperture for the fluid and a body, provided with shutter means and mobile with respect to said passage aperture to alternatively define at least a closed configuration and an open configuration of said valve unit, said body also comprising elastic means that are integrated in a single body with said shutter means and that are configured as a helicoidal spring obtained by making a helicoidal groove in a wall of said body, so as to allow said body to elastically deform between an extended position, in which said shutter means close said passage aperture, and a compressed position, in which said shutter means are distanced from said passage aperture; and - a lid disposed to close an opening of said container, and comprising holding means disposed to engage with attachment means of said valve unit, so as to allow the connection between said valve unit and said lid. - a valve unit comprising a passage aperture for the fluid and a body, provided with shutter means and mobile with respect to said passage aperture to alternatively define at least a closed configuration and an open configuration of said valve unit, said body also comprising elastic means that are integrated in a single body with said shutter means and that are configured as a helicoidal spring obtained by making a helicoidal groove in a wall of said body, so as to allow said body to elastically deform between an extended position, in which said shutter means close said passage aperture, and a compressed position, in which said shutter means are distanced from said passage aperture; and - a lid disposed to close an opening of said container, and comprising holding means disposed to engage with attachment means of said valve unit, so as to allow the connection between said valve unit and said lid.
An electrosurgical generator for providing electrosurgical energy to an electrode of an electrosurgical instrument, the electrosurgical generator comprising: an output stage configured to provide electrosurgical energy to the electrode of the electrosurgical instrument; a sensor (370, 380) configured to sense arcing patterns of the electrosurgical energy provided to tissue by the electrode; and a controller coupled to the output stage and the sensor (370, 380), the controller configured to control the level of electrosurgical energy delivered to the electrode based on the sensed arcing patterns, characterized in that the controller is further configured to determine an indicator of drag force on the electrode of the electrosurgical instrument based on the sensed arcing patterns by analysing characteristics of the voltage and/or current waveform of the electrosurgical energy delivered to the tissue, and to control the level of electrosurgical energy delivered to the electrode based on the determined indicator of drag force so as to achieve a predetermined drag force setting. an output stage configured to provide electrosurgical energy to the electrode of the electrosurgical instrument; a sensor (370, 380) configured to sense arcing patterns of the electrosurgical energy provided to tissue by the electrode; and a controller coupled to the output stage and the sensor (370, 380), the controller configured to control the level of electrosurgical energy delivered to the electrode based on the sensed arcing patterns, characterized in that the controller is further configured to determine an indicator of drag force on the electrode of the electrosurgical instrument based on the sensed arcing patterns by analysing characteristics of the voltage and/or current waveform of the electrosurgical energy delivered to the tissue, and to control the level of electrosurgical energy delivered to the electrode based on the determined indicator of drag force so as to achieve a predetermined drag force setting.
An electric machine including a rotor cooled by a single-plate base ventilator including blades preferably consisting of a single piece with the plate, and a booster attached to the single-plate ventilator, this booster preferably including a plate positioned opposite that of the base ventilator, wherein the booster includes blade extensions positioned radially as a continuation of the blades of the base ventilator, characterized in that the blade extensions having indentations and the blades being positioned in the thickness of these indentations, and the blade extensions each extending towards the center by a radial rib overlapping a corresponding blade, the height of which decreases as it approaches the center.
An isothiocyanate composition containing: an isothiocyanate according to formula R 1 (̵NCS) n wherein R 1 represents one group selected from the group consisting of C1 to 22 saturated aliphatic groups or C6 to 22 aromatic groups, the group optionally including an oxygen atom and/or nitrogen atom, and n representing an integer of 1 to 10; and a compound having at least one type of functional group selected from the group consisting of groups represented by the following formula and formula, wherein the isothiocyanate composition includes isothiocyanate at 97 wt% or greater based on the total mass of the isothiocyanate composition, with the total of the groups represented by formula and being at least 0.1 molppm and no greater than 1.0 × 10 4 molppm with respect to the total amount of isothiocyanate groups in the composition wherein the compound having a group represented by formula or is a compound represented by the following formula wherein R 1 represents one group selected from the group consisting of C1 to 22 saturated aliphatic groups or C6 to 22 aromatic groups, the group optionally including an oxygen atom and/or nitrogen atom, and n representing an integer of 1 to 10, x, y and z each independently represent an integer of 0 to n, and n-z-y and n-x-y are both an integer of 0 or greater. an isothiocyanate according to formula R 1 (̵NCS) n wherein R 1 represents one group selected from the group consisting of C1 to 22 saturated aliphatic groups or C6 to 22 aromatic groups, the group optionally including an oxygen atom and/or nitrogen atom, and n representing an integer of 1 to 10; and a compound having at least one type of functional group selected from the group consisting of groups represented by the following formula and formula, wherein the isothiocyanate composition includes isothiocyanate at 97 wt% or greater based on the total mass of the isothiocyanate composition, with the total of the groups represented by formula and being at least 0.1 molppm and no greater than 1.0 × 10 4 molppm with respect to the total amount of isothiocyanate groups in the composition wherein the compound having a group represented by formula or is a compound represented by the following formula wherein R 1 represents one group selected from the group consisting of C1 to 22 saturated aliphatic groups or C6 to 22 aromatic groups, the group optionally including an oxygen atom and/or nitrogen atom, and n representing an integer of 1 to 10, x, y and z each independently represent an integer of 0 to n, and n-z-y and n-x-y are both an integer of 0 or greater. wherein R 1 represents one group selected from the group consisting of C1 to 22 saturated aliphatic groups or C6 to 22 aromatic groups, the group optionally including an oxygen atom and/or nitrogen atom, and n representing an integer of 1 to 10, x, y and z each independently represent an integer of 0 to n, and n-z-y and n-x-y are both an integer of 0 or greater.
A method for synthesizing a deuterated dextromethorphan of Formula the method comprising: (i) N-demethylating the tertiary amine of a dextromethorphan compound of Formula to obtain an N-demethylated compound of Formula (ii) deuterating the N-demethylated compound of Formula to a compound of Formula by N-methylation in the presence of a base and iodomethane-D 3 at a temperature in the range of -90°C to 90°C inclusive; (iii) O-demethylating the methoxy group of Formula to a compound of Formula by mixing a compound of Formula with a suitable acid and heating until the level of the compound of Formula is ≤5% and (iv) deuterating the O-demethylated compound of Formula to the compound of Formula by O-methylation in the presence of a base and iodomethane-D 3 at temperatures in the range of -10°C to 10°C inclusive. (i) N-demethylating the tertiary amine of a dextromethorphan compound of Formula to obtain an N-demethylated compound of Formula (ii) deuterating the N-demethylated compound of Formula to a compound of Formula by N-methylation in the presence of a base and iodomethane-D 3 at a temperature in the range of -90°C to 90°C inclusive; (iii) O-demethylating the methoxy group of Formula to a compound of Formula by mixing a compound of Formula with a suitable acid and heating until the level of the compound of Formula is ≤5% and (iv) deuterating the O-demethylated compound of Formula to the compound of Formula by O-methylation in the presence of a base and iodomethane-D 3 at temperatures in the range of -10°C to 10°C inclusive.
A device (1; 2) for stimulating neurons, comprising - a non-invasive stimulation unit for generating stimuli in a plurality of stimulation channels, the stimulation unit being designed such that the stimuli stimulate a neuron population in the brain and/or spinal cord of a patient via the stimulation channels at respectively different points, and - a control unit, which operates the stimulation unit during a first time interval and a second time interval following the first time interval in different stimulation modes, wherein - the control unit controls the stimulation unit during at least 75% of the duration of the first time interval in a first stimulation mode such that the stimulation unit repetitively generates sequences of stimuli and the order of the stimulation channels, in which the stimuli are generated within a sequence, is constant for not more than 5 successively generated sequences and is then varied, - the control unit controls the stimulation unit during at least 75% of the duration of the second time interval in a second stimulation mode such that the stimulation unit repetitively generates sequences of stimuli and the order of the stimulation channels, in which the stimuli are generated within a sequence, is constant for at least 25 successively generated sequences and is then varied, and - wherein the intensity of the stimuli in the first stimulation mode is lower than or equal to a predetermined stimulus intensity and the intensity of the stimuli in the second stimulation mode is at least 1.3 times the predetermined stimulus intensity. - a non-invasive stimulation unit for generating stimuli in a plurality of stimulation channels, the stimulation unit being designed such that the stimuli stimulate a neuron population in the brain and/or spinal cord of a patient via the stimulation channels at respectively different points, and - a control unit, which operates the stimulation unit during a first time interval and a second time interval following the first time interval in different stimulation modes, wherein - the control unit controls the stimulation unit during at least 75% of the duration of the first time interval in a first stimulation mode such that the stimulation unit repetitively generates sequences of stimuli and the order of the stimulation channels, in which the stimuli are generated within a sequence, is constant for not more than 5 successively generated sequences and is then varied, - the control unit controls the stimulation unit during at least 75% of the duration of the second time interval in a second stimulation mode such that the stimulation unit repetitively generates sequences of stimuli and the order of the stimulation channels, in which the stimuli are generated within a sequence, is constant for at least 25 successively generated sequences and is then varied, and - wherein the intensity of the stimuli in the first stimulation mode is lower than or equal to a predetermined stimulus intensity and the intensity of the stimuli in the second stimulation mode is at least 1.3 times the predetermined stimulus intensity.
An information processing apparatus that executes a control instruction operated from a terminal device, the information processing apparatus comprising: an analyzing unit that analyzes, when the control instruction operated from the terminal device satisfies a first condition, whether the control instruction is the content that includes therein an additional condition that is related to the first condition; an additional condition determination unit that determines, when the analyzing unit analyzes that the control instruction is the content that includes therein the additional condition that is related to the first condition, whether the control instruction satisfies the additional condition; a second determination unit that determines, when the additional condition determination unit determines that the control instruction satisfies the additional condition, whether the control instruction satisfies a second condition; and a processing unit (143, 144) that executes a process related to the control instruction in accordance with the determination performed by the second determination unit. an analyzing unit that analyzes, when the control instruction operated from the terminal device satisfies a first condition, whether the control instruction is the content that includes therein an additional condition that is related to the first condition; an additional condition determination unit that determines, when the analyzing unit analyzes that the control instruction is the content that includes therein the additional condition that is related to the first condition, whether the control instruction satisfies the additional condition; a second determination unit that determines, when the additional condition determination unit determines that the control instruction satisfies the additional condition, whether the control instruction satisfies a second condition; and a processing unit (143, 144) that executes a process related to the control instruction in accordance with the determination performed by the second determination unit.
A ball joint comprising: a metal housing with an opening and a cylindrical peripheral wall portion; a ball stud with a shaft portion and a ball portion; a ball seat formed of a synthetic resin and accommodated in the housing, the ball seat comprising a recessed spherical surface into which the ball portion is inserted, a projecting portion having an inner diameter smaller than an outer diameter of the ball portion so as to inhibit the ball portion from being dislodged from the recessed spherical surface, and a slope portion formed at a hole portion through which the shaft portion is inserted, wherein the slope portion guides the ball portion when the ball portion is inserted into the recessed spherical surface, the slope portion being shaped to have an inner diameter increasing from the projecting portion toward the opening; and characterised by: a caulking portion comprising a projecting edge formed integrally at an end wall of the opening in the housing and folded toward an end surface of the ball seat, the caulking portion being arranged so as to overlap the end surface of the ball seat and the projecting edge extending along the slope portion toward the projecting portion, wherein the thickness t of the projecting edge is set equal to 40 to 60% of the thickness of the peripheral wall portion and the length of the projecting edge is set twice to four times as great as the thickness (t). a metal housing with an opening and a cylindrical peripheral wall portion; a ball stud with a shaft portion and a ball portion; a ball seat formed of a synthetic resin and accommodated in the housing, the ball seat comprising a recessed spherical surface into which the ball portion is inserted, a projecting portion having an inner diameter smaller than an outer diameter of the ball portion so as to inhibit the ball portion from being dislodged from the recessed spherical surface, and a slope portion formed at a hole portion through which the shaft portion is inserted, a caulking portion comprising a projecting edge formed integrally at an end wall of the opening in the housing and folded toward an end surface of the ball seat, the caulking portion being arranged so as to overlap the end surface of the ball seat and the projecting edge extending along the slope portion toward the projecting portion, wherein the thickness t of the projecting edge is set equal to 40 to 60% of the thickness of the peripheral wall portion and the length of the projecting edge is set twice to four times as great as the thickness (t).
Method for operating a wind turbine comprising a drive train driving one or more electrical generators (23, 31) that supply power to an electric grid, the drive train including a rotor hub, to which one or more blades are attached, a main shaft, a gearbox and connecting shafts to said one or more electrical generators (23, 31), wherein in events that can create a load inversion in the gearbox, a drive train dump load is activated by a controller_for ensuring that the drive train torque has a constant direction, avoiding the backlashes in the gearbox, said dump load consisting of power absorbed by one or several means chosen among means specifically dedicated to the absorption of said dump load and means present at the wind turbine for other purposes, and characterized in that when the drive train torque is above a predetermined value, the drive train dump load is deactivated by the controller.