A heterocycle derivative compound having Formula I: wherein, in Formula I, each of X 1, X 2, and X 3 is independently carbon or nitrogen, provided that at least one of X 1, X 2, and X 3 is nitrogen, each of R 1, R 2, R 3 and R 4 may be same or different and is independently selected from the group consisting of hydrogen; hydroxy; C 1 -C 6 alkyl; C 2 -C 7 alkenyl; C 2 -C 7 alkynyl; C 1 -C 6 hydroxyalkyl; C 1 -C 6 haloalkyl; C 1 -C 6 alkoxy; C 1 -C 6 haloalkoxy; halogen; phenyl; cyano; nitro; amino; carboxylic acid group; phosphoric acid group; N-oxide; amide; C 1 -C 6 alkylamide; aldehyde; hydroxamic acid; C 1 -C 6 alkylsulfide; C 1 -C 6 alkylthioxo; C 1 -C 6 alkylsulfonyl; C 1 -C 6 oximealkyl; C 1 -C 6 aminoalkyl; C 3 -C 8 alkylcarbonylalkyl; C 2 -C 7 alkanoyl; C 2 -C 7 alkoxycarbonyl; C 2 -C 7 alkanoyloxy; C 3 -C 12 mono or bicycloalkyl; C 4 -C 12 cycloalkylalkyl; C 6 -C 12 aryl;, saturated or unsaturated C 3 -C 12 mono or polycarbocyclyl; and, saturated or unsaturated 3- to 12-membered mono or polyheterocyclyl containing 1 to 3 heteroatoms, provided that when X 1 is nitrogen, R 2 does not exist; when X 2 is nitrogen, R 3 does not exist; and when X 3 is nitrogen, R 4 does not exist, or each of R 1 -R 2, R 2 -R 3 and R 3 -R 4 pairs may be independently fused to form a saturated or unsaturated 5- to 11-membered carbocycle or heterocycle, each of R 5, R 6, R 7 and R 8 may be same or different and is independently selected from the group consisting of hydrogen; hydroxy; C 1 -C 6 alkyl; C 2 -C 7 alkenyl; C 2 -C 7 alkynyl; C 1 -C 6 hydroxyalkyl; C 1 -C 6 haloalkyl; C 1 -C 6 alkoxy; C 1 -C 6 haloalkoxy; C 2 -C 7 alkanoyl; phosphoric acid group; N-oxide; amide; C 1 -C 6 alkylamide; aldehyde; hydroxamic acid; C 1 -C 6 alkylsulfide; C 1 -C 6 alkylthioxo; C 1 -C 6 alkylsulfonyl; C 1 -C 6 oximealkyl; C 1 -C 6 aminoalkyl; C 3 -C 8 alkylcarbonylalkyl; halogen; phenyl; cyano; nitro; amino; and carboxylic acid group, or R 5 and R 6 together with a carbon atom to which they are attached may form a carbonyl group (C=O) or thioxo group (C=S), or R 7 and R 8 together with a carbon atom to which they are attached may form a carbonyl group (C=O) or thioxo group (C=S), L may form a carbonyl group (-C(=O)-), sulfonyl group (-S(=O) 2 -), C 1 -C 6 alkyl carbonyl, carbonyl C 1 -C 6 alkyl or thioxo group (-C(=S)-), and Y is selected from the group consisting of saturated or unsaturated C 3 -C 12 mono or polycarbocyclyl substituted with R 9, R 10, and R 11; and saturated or unsaturated 3- to 12-membered mono or polyheterocyclyl containing 1 to 3 heteroatoms and being substituted with R 9, R 10, and R 11, wherein each of R 9, R 10 and R 11 is independently selected from the group consisting of hydrogen; hydroxy; C 1 -C 6 alkyl; C 2 -C 7 alkenyl; C 2 -C 7 alkynyl; C 1 -C 6 hydroxyalkyl; C 1 -C 6 haloalkyl; C 1 -C 6 alkoxy; C 1 -C 6 haloalkoxy; halogen; C 1 -C 6 alkylsulfide; C 1 -C 6 alkylthioxo; hydroxamic acid; phenyl; cyano; nitro; amino; carboxylic acid group; amide; C 1 -C 6 alkylamide; C 2 -C 7 alkanoyl; aldehyde; C 3 -C 8 ester; C 3 -C 8 esteroxy; C 1 -C 6 alkylsulfonyl; C 1 -C 6 oximealkyl; C 1 -C 6 aminoalkyl; C 3 -C 8 alkylcarbonylalkyl; phosphoric acid group; and N-oxide, provided that when Y is phenyl, i) at least one of R 9, R 10 and R 11 is hydroxy or ii) all of R 9, R 10 and R 11 are other than hydrogen if none of R 9, R 10 and R 11 is hydroxy, and when Y is pyridinyl, at least one of R 9, R 10 and R 11 is not hydrogen, or racemate, or pharmaceutically acceptable salt thereof.