A process for the preparation of a compound of Formula, the process comprising: (a) forming a reaction mixture by combining a compound of Formula with MCO 3, a catalytic additive selected from the group consisting of potassium iodide, sodium iodide and cesium iodide, and R 1 X 1, the amount of alkenyl impurity comprising R 1 X 1 being less than 0.15% by weight, wherein the molar ratio of the compound of Formula to catalytic additive is from 1:1 to 1:1.5; the molar ratio of the compound of Formula to R 1 X 1 is from 1:1 to 1:1.35; and the molar ratio of the compound of Formula to MCO 3 is from 1:1 to 1:2.5; and (b) heating the reaction mixture to a temperature of less than 60° C to form the compound of Formula according to the following reaction scheme: wherein: R 1 is cyclopropylmethyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {-}OH, {-}NH 2, {-}SH, {-}SR 11, and {-}OR 11; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; R 8 is selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 9, R 10, and R 11 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; M is selected from the group consisting of a metal cation having a charge of +2 and a metal cation group having a charge of +2; X is a heteroatom; X 1 is a halogen; and the alkenyl impurity is a butenyl impurity. (a) forming a reaction mixture by combining a compound of Formula with MCO 3, a catalytic additive selected from the group consisting of potassium iodide, sodium iodide and cesium iodide, and R 1 X 1, the amount of alkenyl impurity comprising R 1 X 1 being less than 0.15% by weight, wherein the molar ratio of the compound of Formula to catalytic additive is from 1:1 to 1:1.5; the molar ratio of the compound of Formula to R 1 X 1 is from 1:1 to 1:1.35; and the molar ratio of the compound of Formula to MCO 3 is from 1:1 to 1:2.5; and (b) heating the reaction mixture to a temperature of less than 60° C to form the compound of Formula according to the following reaction scheme: wherein: R 1 is cyclopropylmethyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {-}OH, {-}NH 2, {-}SH, {-}SR 11, and {-}OR 11; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; R 8 is selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 9, R 10, and R 11 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; M is selected from the group consisting of a metal cation having a charge of +2 and a metal cation group having a charge of +2; X is a heteroatom; X 1 is a halogen; and the alkenyl impurity is a butenyl impurity. R 1 is cyclopropylmethyl; R 2 and R 3 are independently selected from the group consisting of hydrogen, hydrocarbyl and substituted hydrocarbyl; R 4 and R 5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {-}OH, {-}NH 2, {-}SH, {-}SR 11, and {-}OR 11; R 6 and R 7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl; R 8 is selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl; R 9, R 10, and R 11 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl; M is selected from the group consisting of a metal cation having a charge of +2 and a metal cation group having a charge of +2; X is a heteroatom; X 1 is a halogen; and the alkenyl impurity is a butenyl impurity.