mhurhangee/ep-ind-claims huggingface dataset:
A sustained-release oral dosage form for once daily administration comprising (a) a bilayer core comprising: (i) a drug layer comprising from 5 to 640 mg of oxycodone or a pharmaceutically acceptable salt thereof and at least one polymer hydrogel; and (ii) a displacement layer comprising an osmopolymer; and (b) a semipermeable wall surrounding the bilayer core having a passageway disposed therein for the release of said oxycodone or pharmaceutically acceptable salt thereof, wherein the semipermeable wall comprises a member selected from the group consisting of a cellulose ester polymer, a cellulose ether polymer and a cellulose ester-ether polymer; and said oxycodone or pharmaceutically acceptable salt thereof is the only drug in the dosage form. (a) a bilayer core comprising: (i) a drug layer comprising from 5 to 640 mg of oxycodone or a pharmaceutically acceptable salt thereof and at least one polymer hydrogel; and (ii) a displacement layer comprising an osmopolymer; and (i) a drug layer comprising from 5 to 640 mg of oxycodone or a pharmaceutically acceptable salt thereof and at least one polymer hydrogel; and (ii) a displacement layer comprising an osmopolymer; and (b) a semipermeable wall surrounding the bilayer core having a passageway disposed therein for the release of said oxycodone or pharmaceutically acceptable salt thereof,
A method for detecting and enumerating viable microorganisms in a sample suspected of containing said microorganisms, in which the sample is derived from any of the group selected from industrial cooling waters, drinking waters, and natural waters, by Contacting said microorganisms of said sample with at least one repair compound and a growth medium, and Incubating the product of steps, and Detecting and quantifying said viable microorganisms, in which the microorganisms are of the species Legionella pneumophila, and in which the repair compound directly or indirectly causes an effect on the metabolism to reduce the oxidative stress of the microorganism, in which the repair compound comprises glutamic acid (or salt thereof) and pyruvic acid (or salt thereof), in which step comprises: contacting said sample with a repair medium, preferably a non-selective repair medium, containing said repair compound and then bringing this into contact with the growth medium; or contacting said sample with the growth medium containing said repair compound, wherein the pyruvic acid is present in a medium at a concentration between 0.01 and 1% by weight calculated as the sodium salt, and the amount of glutamic acid is between 0.01 and 5% by weight calculated as the sodium salt, and in which the growth medium is buffered charcoal yeast extract (BCYE) agar growth medium or glycine, vancomycine, polymyxine B, cycloheximide (GVPC) growth medium. Contacting said microorganisms of said sample with at least one repair compound and a growth medium, and Incubating the product of steps, and Detecting and quantifying said viable microorganisms, contacting said sample with a repair medium, preferably a non-selective repair medium, containing said repair compound and then bringing this into contact with the growth medium; or contacting said sample with the growth medium containing said repair compound,
A horizontal articulated robot comprising: a first arm coupled to a base; a second arm coupled to the base via at least the first arm; a first drive source incorporated in the base and adapted to rotate the first arm in a horizontal direction; a second drive source incorporated in the second arm and adapted to rotate the second arm in a horizontal direction; and characterised by an angular velocity sensor installed in the second arm, wherein the first drive source is driven based on the angular velocity obtained by the angular velocity sensor to thereby suppress vibration of the first arm, further comprising: a belt disposed inside the second arm, and adapted to transmit a drive force of a third drive source to a displacement member displaced with respect to the second arm, wherein the angular velocity sensor is disposed above the belt. a first arm coupled to a base; a second arm coupled to the base via at least the first arm; a first drive source incorporated in the base and adapted to rotate the first arm in a horizontal direction; a second drive source incorporated in the second arm and adapted to rotate the second arm in a horizontal direction; and characterised by an angular velocity sensor installed in the second arm, wherein the first drive source is driven based on the angular velocity obtained by the angular velocity sensor to thereby suppress vibration of the first arm, further comprising: a belt disposed inside the second arm, and adapted to transmit a drive force of a third drive source to a displacement member displaced with respect to the second arm, wherein the angular velocity sensor is disposed above the belt. a belt disposed inside the second arm, and adapted to transmit a drive force of a third drive source to a displacement member displaced with respect to the second arm, wherein the angular velocity sensor is disposed above the belt.
An active medical device comprising: - a generator for functional electric nerve stimulation, comprising means for outputting multiphasic nerve stimulation pulse trains; - a stimulation lead to be disposed on or near a structure of the nervous system of a patient carrying the device for the application of the nerve stimulation pulse trains to this structure; - at least one sensor delivering a control signal representative of a physiological and/or physical parameter likely to be influenced by the delivery of the nerve stimulation pulse trains; and - an automatic load compensation control circuit (24, 26, 28) including means for inputting the control signal from the at least one sensor, characterized in that each pulse train comprises: - at least one stimulation pulse; and - at least one compensating pulse comprising: a precharge pulse preceding the stimulation pulse; and/or an afterload pulse following the stimulation pulse; a passive discharge pulse terminating the pulse train; or a combination of the preceding, the stimulation and compensating pulses being current pulses whose direction, duration and amplitude are controlled, and the compensating pulses providing an accumulated electric charge compensating for the electrical charge of at least one stimulation pulse, and in that the automatic load compensation control circuit (24, 26, 28) further comprises: • means for determining a magnitude and/or duration of the compensating pulse based on at least one predetermined criterion; and • means for outputting to the generator a drive signal of the compensating pulse to be generated by it. - a generator for functional electric nerve stimulation, comprising means for outputting multiphasic nerve stimulation pulse trains; - a stimulation lead to be disposed on or near a structure of the nervous system of a patient carrying the device for the application of the nerve stimulation pulse trains to this structure; - at least one sensor delivering a control signal representative of a physiological and/or physical parameter likely to be influenced by the delivery of the nerve stimulation pulse trains; and - an automatic load compensation control circuit (24, 26, 28) including means for inputting the control signal from the at least one sensor, - at least one stimulation pulse; and - at least one compensating pulse comprising: a precharge pulse preceding the stimulation pulse; and/or an afterload pulse following the stimulation pulse; a passive discharge pulse terminating the pulse train; or a combination of the preceding, • means for determining a magnitude and/or duration of the compensating pulse based on at least one predetermined criterion; and • means for outputting to the generator a drive signal of the compensating pulse to be generated by it.
Process for the preparation of a dental shaped body, in which at least two suspensions of a zirconium oxide starting material with different compositions are gelled by at least partially gelling a first suspension and then applying a second suspension to the first and gelling it as well, wherein the suspensions comprise a gelling agent and wherein the suspensions have different colors.
A method for treating a cladding within which there is a sintered material composed wholly or partly of sintered calcium hydride, the method comprising a step during which the sintered material is contacted with a reaction mixture containing in molar percentages 0.5% to 5% of steam, 5% to 25% of carbon dioxide, and 74.5% to 94.5% of a chemically inert gas, the contacting being carried out for a duration allowing the sintered calcium hydride to be converted into a calcium carbonate powder.
Window comprising a device for regulating the passage of light through a light-transmitting area, where the device comprises two glass substrates and a switching layer, arranged between these substrate layers, which comprises a liquid-crystalline medium comprising at least one dichroic dye, and where the switching layer has a degree of anisotropy R of at least 0.65 and a light transmittance in the bright state τ v bright, in accordance with the EN410 standard, of 40% to 90%, where the switching layer comprises three or more different dichroic dyes, where the liquid-crystalline medium has a clearing point in the temperature range from 70°C to 170°C, and where the device has an area of at least 0.05 m 2.
A molten bath-based process for direct smelting metalliferous material and producing molten metal in a direct smelting vessel that contains a molten bath that has a metal layer that is at least 900 mm deep includes selecting operating parameters of the process including, injecting a feed material with a lance pressure drop of at least 1 bar, an injection velocity of injected feed material of at least 40 m/s, and a solids/gas ratio of an injected solid feed material and a carrier gas of at least 10 kg solids per Nm 3 gas, so that the feed material, including, the solid feed material and the carrier gas, is injected from above the metal layer into the metal layer via at least one solids injection lance with sufficient momentum to penetrate to a depth of at least 100 mm below a nominal quiescent surface of the metal layer, as calculated using a McMaster injection model, to cause upward movement of molten material (22, 23) and gas from the metal layer.
A method for characterizing a subterranean formation comprising: placing a subterranean fluid into a well extending into at least a portion of the subterranean formation to induce one or more fractures(40, 50), wherein the one or more fractures is induced by stimulation during multi-stage hydraulic fracturing treatment; measuring pressure response via one or more pressure sensors (20, 30) installed in the subterranean formation; and determining a physical feature of the one or more fractures (40, 50), characterised in that the pressure response is poroelastic and characterised by building a geomechanical model of a propagating tensile fracture in a poro-linear-elastic material, matching the pressure response of a fracturing stage and estimating the height, length, and orientation of the hydraulic fracture. placing a subterranean fluid into a well extending into at least a portion of the subterranean formation to induce one or more fractures(40, 50), wherein the one or more fractures is induced by stimulation during multi-stage hydraulic fracturing treatment; measuring pressure response via one or more pressure sensors (20, 30) installed in the subterranean formation; and determining a physical feature of the one or more fractures (40, 50), characterised in that the pressure response is poroelastic and characterised by building a geomechanical model of a propagating tensile fracture in a poro-linear-elastic material, matching the pressure response of a fracturing stage and estimating the height, length, and orientation of the hydraulic fracture.
A polymerizable monomer, which is represented by the following general formula: in the general formula, Ar 1 and Ar 2 each represent a substituted or unsubstituted aromatic group having a valence selected from divalence or trivalence, and may be identical to or different from each other, L 1 and L 2 each represent a divalent substituted hydrocarbon group having a main chain with a number of atoms within a range of from 2 to 10 and containing at least one hydroxy group, and may be identical to or different from each other, R 1 and R 2 each represent hydrogen or a methyl group, q is 1, and m1 and m2 each represent 1 or 2; provided that the polymerizable monomer is other than:
Magnetic gear unit having at least two magnets (1, 2), characterized in that at least one first magnet is arranged such that it can rotate about an axis and at least one second magnet is arranged in a displaceable manner along an axis, in such a way that the distance between the at least two magnets (1, 2) can be changed, wherein owing to said rotation, the position of the magnet poles S and N of the first magnet changes in relation to the second magnet, as a result of which this second magnet can be set into a repetitive reciprocating movement by attraction and repulsion and wherein the at least one second magnet, which can be displaced along an axis, interacts with a connecting rod of a crank drive, whereby the translatory movement thereof is transferable to a wheel, characterized in that the connecting rod and the wheel are connected to a connecting device that can be engaged and disengaged, in such a way that a drive-effective frictional connection between the connecting rod and the wheel takes place only in at least one predetermined region and thus the drive force can only be transmitted from the connecting rod to the wheel in the corresponding, at least one region.
Use of an amino acid substitution to a human IgG Fc region for attenuating the post-translational fucosylation of the human IgG Fc region, wherein the thus modified human IgG Fc region: comprises an amino acid substitution relative to a wild type Fc region, wherein said amino acid substitution is at one or more of positions L234, L235, F243, R292, Y300, V305, or P396; and exhibits a ratio of high mannose oligosaccharide glycosylation to complex oligosaccharide glycosylation that is greater than 0.2. comprises an amino acid substitution relative to a wild type Fc region, wherein said amino acid substitution is at one or more of positions L234, L235, F243, R292, Y300, V305, or P396; and exhibits a ratio of high mannose oligosaccharide glycosylation to complex oligosaccharide glycosylation that is greater than 0.2.
A non-human ES cell or a non-human mammalian cell comprising a chromosomal DNA sequence flanked by site specific recombination sites and transposon elements, wherein the sequence encodes a Cas endonuclease and one or more gRNAs and the transposon elements can be used to excise the sequence from the genome.
Pressure-limiting valve having a housing and having a valve seat which is formed in said housing and which can be closed by means of a spring-loaded closing element of the pressure-limiting valve, characterized in that the housing is composed of cast iron with spheroidal graphite, wherein the housing is surface-hardened at least in a region of the valve seat.
Method for processing a digital signal, implemented during a decoding of said signal to replace a succession of samples lost on decoding, the method comprising the steps: - generating a structure of a replacement signal in respect of the lost succession, said structure comprising spectral components determined on the basis of valid samples received on decoding and prior to said lost succession of samples, - generating a residual between a digital signal available at the decoder comprising valid samples received and a signal generated on the basis of said spectral components, - extracting blocks of said residual, in which method said blocks are injected into said structure by additions with overlap following block weighting windows, said injected blocks overlapping at least partially in time, and in which, said blocks having an instant of start of extracted block (i k) and a block duration (L k), at least one parameter from among: - said instant of start of extracted block, - said block duration, - an instant of start of writing of injected block (j k), and - a degree of overlap between two successive injected blocks, is variable between at least two extracted or injected blocks. - generating a structure of a replacement signal in respect of the lost succession, said structure comprising spectral components determined on the basis of valid samples received on decoding and prior to said lost succession of samples, - generating a residual between a digital signal available at the decoder comprising valid samples received and a signal generated on the basis of said spectral components, - extracting blocks of said residual, - said instant of start of extracted block, - said block duration, - an instant of start of writing of injected block (j k), and - a degree of overlap between two successive injected blocks,
A tire comprising a tread portion, a pair of sidewall portions continuous on both sides of the tread portion, bead portions continuous on each sidewall portion, side reinforcing rubbers, and a carcass formed of plies of radially arranged cords extending toroidally between the pair of bead portions, wherein: when the tire is mounted to a rim, and an internal pressure of 250 kPa or more is applied to the tire, in a case where a sectional width SW of the tire is less than 165 mm, a ratio of the sectional width SW to an outer diameter OD of the tire, SW/OD, is 0.26 or less; and in a case where the sectional width SW of the tire is 165 mm or more, the sectional width SW and the outer diameter OD of the tire satisfy a relation expression OD≥2.135×SW+282.3 (mm); characterised in that: the tire is a run-flat tire; in that the side reinforcing rubbers comprise crescent-like cross section disposed on the sidewall portions; in that when H1 (mm) is a tire radial maximum length of the side reinforcing rubber in a tire widthwise cross section in a reference state where the tire is mounted to a rim and filled with a predetermined internal pressure with no load applied thereon, a relation expression 10 mm ≤ SW / OD × H 1 ≤ 20 mm is satisfied; in that the 50% stretch modulus of the side reinforcing rubbers is 1.5 to 6.0 Mpa; and in that the tire has an air volume of 15000 cm 3 or more. when the tire is mounted to a rim, and an internal pressure of 250 kPa or more is applied to the tire, in a case where a sectional width SW of the tire is less than 165 mm, a ratio of the sectional width SW to an outer diameter OD of the tire, SW/OD, is 0.26 or less; and in a case where the sectional width SW of the tire is 165 mm or more, the sectional width SW and the outer diameter OD of the tire satisfy a relation expression OD≥2.135×SW+282.3 (mm); characterised in that: the tire is a run-flat tire; in that the side reinforcing rubbers comprise crescent-like cross section disposed on the sidewall portions; in that when H1 (mm) is a tire radial maximum length of the side reinforcing rubber in a tire widthwise cross section in a reference state where the tire is mounted to a rim and filled with a predetermined internal pressure with no load applied thereon, a relation expression 10 mm ≤ SW / OD × H 1 ≤ 20 mm is satisfied; in that the 50% stretch modulus of the side reinforcing rubbers is 1.5 to 6.0 Mpa; and in that the tire has an air volume of 15000 cm 3 or more.
A thermoplastic resin reinforced sheet material comprising: a reinforced fiber sheet material which is formed into a sheet shape by drawing and aligning a plurality of reinforcing fibers in a predetermined direction and whose weight per unit area is 80 g/m 2 or less; a fabric which is formed of a thermoplastic resin fiber material; and a thermoplastic resin material for bonding which is melted or softened at a temperature lower than a melting temperature of the fabric; characterised in that the fabric has a fineness of 5.6 decitex to 84 decitex and whose basis weight per unit area is 5 g/m 2 to 90 g/m 2; the thermoplastic resin material discretely causes the reinforced fiber sheet material and the fabric to adhere; and the fabric has a pore volume rate of 50 % or more. a reinforced fiber sheet material which is formed into a sheet shape by drawing and aligning a plurality of reinforcing fibers in a predetermined direction and whose weight per unit area is 80 g/m 2 or less; a fabric which is formed of a thermoplastic resin fiber material; and a thermoplastic resin material for bonding which is melted or softened at a temperature lower than a melting temperature of the fabric; characterised in that the fabric has a fineness of 5.6 decitex to 84 decitex and whose basis weight per unit area is 5 g/m 2 to 90 g/m 2; the thermoplastic resin material discretely causes the reinforced fiber sheet material and the fabric to adhere; and the fabric has a pore volume rate of 50 % or more.
Preformed catalytic system based at least: • on a preformation conjugated diene monomer, • on a metallocene of formula, • on an organometallic compound as cocatalyst, {P(Cp 1)(Cp 2)Y} - Y denoting a group comprising a metal atom which is a rare earth metal, - Cp 1 and Cp 2, which are identical or different, being selected from the group consisting of fluorenyl groups, cyclopentadienyl groups and indenyl groups, the groups being substituted or unsubstituted, - P being a group bridging the two Cp 1 and Cp 2 groups and comprising a silicon or carbon atom. • on a preformation conjugated diene monomer, • on a metallocene of formula, • on an organometallic compound as cocatalyst, {P(Cp 1)(Cp 2)Y} - Y denoting a group comprising a metal atom which is a rare earth metal, - Cp 1 and Cp 2, which are identical or different, being selected from the group consisting of fluorenyl groups, cyclopentadienyl groups and indenyl groups, the groups being substituted or unsubstituted, - P being a group bridging the two Cp 1 and Cp 2 groups and comprising a silicon or carbon atom. - Y denoting a group comprising a metal atom which is a rare earth metal, - Cp 1 and Cp 2, which are identical or different, being selected from the group consisting of fluorenyl groups, cyclopentadienyl groups and indenyl groups, the groups being substituted or unsubstituted, - P being a group bridging the two Cp 1 and Cp 2 groups and comprising a silicon or carbon atom.
A lubricating oil for ship propulsor bearings, comprising - a base oil, - a water-soluble thickening agent, and - a water-soluble anticorrosive agent; wherein the content is 80 to 98% by weight, the content of is 1 to 10% by weight, and the content of is 1 to 10% by weight, each relative to the weight of the lubricating oil for ship propulsor bearings; wherein the base oil is a water-soluble alkylene glycol and/or polyalkylene glycol, each having a number average molecular weight of not higher than 1,000; and wherein the water-soluble thickening agent is an ethylene oxide/1,2-propylene oxide adduct derived from a polyamidepolyamine, and having a molecular weight Mn of not lower than 10.000; and wherein a bearing-damaging pressure at 50°C of said lubricating oil for ship propulsor bearings as determined by the method described in the present specification is not lower than 3.5 MPa, and wherein the term "water-soluble" means that the weight of the objective substance capable of dissolving in 100 g of water at 25°C is not lower than 20 g. - a base oil, - a water-soluble thickening agent, and - a water-soluble anticorrosive agent;