An apparatus for carrying out at least one biopsy examination on the breast of a patient, comprising: - an analysis head provided with at least one radiation detection device configured to detect X-rays on a detection plane, and at least one source of X-rays to emit a corresponding beam of X-rays towards the detector, the source and the detection device being mobile with respect to each other so that they can be placed in a plurality of different working acquisition positions; - a breast support surface; - a support base and a biopsy probe which can be fixed to the support base and which is equipped with a needle for the extraction of a sample of breast tissue and with a housing for the needle, this housing being rotatably mounted on the support base to allow modification of the angle of the needle with respect to the breast support surface; - a computerized unit, connected to the detector and configured to produce at least one reconstructed image of a cross-section of the breast representative of anatomical portions of the breast at a predetermined depth along a direction at right angles to the detection plane of the detection device based on images of the patient's breast acquired by the detection device in different working positions; - a user interface, configured to: - allow the display of the reconstructed image of a cross-section of the breast; - allow selection of a target position for extraction of the tissue sample; - allow the display (9I, 9I') of a proposed movement route of the needle through the patient's breast as far as the target position for extraction of the tissue sample; the computerized unit being configured to calculate, based on the selection of the target position for extraction of the tissue sample, the proposed movement route of the needle through the patient's breast as far as the target position for extraction of the tissue sample, the apparatus being characterized in that the user interface is configured to allow the display of a reconstructed image of a cross-section of the breast selected from a plurality of reconstructed images of cross-sections of the breast representative of anatomical portions of the breast at different depths along a direction at right angles to the detection plane of the detection device and wherein the user interface is configured to allow the display of the proposed movement route of the needle through the patient's breast, as far as the target position for extraction of the tissue sample, directly on the reconstructed image of a cross-section of the breast. - an analysis head provided with at least one radiation detection device configured to detect X-rays on a detection plane, and at least one source of X-rays to emit a corresponding beam of X-rays towards the detector, the source and the detection device being mobile with respect to each other so that they can be placed in a plurality of different working acquisition positions; - a breast support surface; - a support base and a biopsy probe which can be fixed to the support base and which is equipped with a needle for the extraction of a sample of breast tissue and with a housing for the needle, this housing being rotatably mounted on the support base to allow modification of the angle of the needle with respect to the breast support surface; - a computerized unit, connected to the detector and configured to produce at least one reconstructed image of a cross-section of the breast representative of anatomical portions of the breast at a predetermined depth along a direction at right angles to the detection plane of the detection device based on images of the patient's breast acquired by the detection device in different working positions; - a user interface, configured to: - allow the display of the reconstructed image of a cross-section of the breast; - allow selection of a target position for extraction of the tissue sample; - allow the display (9I, 9I') of a proposed movement route of the needle through the patient's breast as far as the target position for extraction of the tissue sample;