Method for operating a bioprocess installation for production of a bioproduct, wherein the bioprocess installation comprises a source receptacle for cell cultivation, a harvest receptacle for bioproduction and a clarification setup with a centrifuge, wherein the source receptacle is operated in a cyclical production mode, wherein the cyclical production mode comprises, in this order, the steps of: a) starting the cyclical production mode in the source receptacle with initial cells and cultivation medium, b) cultivating the cells in the source receptacle, thereby obtaining a cell broth comprising cultivated cells, whereby the source receptacle and the cultivation medium are configured to provide source culture environment conditions for the cultivation of the cells, c) discharging a discharge fraction of the cell broth from the source receptacle, d) combining a restart fraction of the cell broth with fresh cultivation medium and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth obtained from step d) from the source receptacle stopping the cyclical production mode, obtaining a discharge fraction, wherein the method further comprises the steps of: i) transferring the discharge fraction to the clarification setup and centrifuging the discharge fraction via the centrifuge, thereby separating the discharge fraction into at least a centrifuged discharge fraction and supernatant and preferably bioproduct, ii) transferring at least part of the centrifuged discharge fraction from step i) and fresh cultivation medium into the harvest receptacle and operating the harvest receptacle in a production mode, whereby the harvest receptacle and the cultivation medium are configured to provide harvest culture environment conditions, producing the bioproduct in the harvest receptacle, wherein steps i) and ii) are executed at least twice with discharge fractions from an execution of step c) and/or step f). wherein the source receptacle is operated in a cyclical production mode, wherein the cyclical production mode comprises, in this order, the steps of: a) starting the cyclical production mode in the source receptacle with initial cells and cultivation medium, b) cultivating the cells in the source receptacle, thereby obtaining a cell broth comprising cultivated cells, whereby the source receptacle and the cultivation medium are configured to provide source culture environment conditions for the cultivation of the cells, c) discharging a discharge fraction of the cell broth from the source receptacle, d) combining a restart fraction of the cell broth with fresh cultivation medium and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth obtained from step d) from the source receptacle stopping the cyclical production mode, obtaining a discharge fraction, a) starting the cyclical production mode in the source receptacle with initial cells and cultivation medium, b) cultivating the cells in the source receptacle, thereby obtaining a cell broth comprising cultivated cells, whereby the source receptacle and the cultivation medium are configured to provide source culture environment conditions for the cultivation of the cells, c) discharging a discharge fraction of the cell broth from the source receptacle, d) combining a restart fraction of the cell broth with fresh cultivation medium and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth obtained from step d) from the source receptacle stopping the cyclical production mode, obtaining a discharge fraction, wherein the method further comprises the steps of: i) transferring the discharge fraction to the clarification setup and centrifuging the discharge fraction via the centrifuge, thereby separating the discharge fraction into at least a centrifuged discharge fraction and supernatant and preferably bioproduct, ii) transferring at least part of the centrifuged discharge fraction from step i) and fresh cultivation medium into the harvest receptacle and operating the harvest receptacle in a production mode, whereby the harvest receptacle and the cultivation medium are configured to provide harvest culture environment conditions, producing the bioproduct in the harvest receptacle, i) transferring the discharge fraction to the clarification setup and centrifuging the discharge fraction via the centrifuge, thereby separating the discharge fraction into at least a centrifuged discharge fraction and supernatant and preferably bioproduct, ii) transferring at least part of the centrifuged discharge fraction from step i) and fresh cultivation medium into the harvest receptacle and operating the harvest receptacle in a production mode, whereby the harvest receptacle and the cultivation medium are configured to provide harvest culture environment conditions, producing the bioproduct in the harvest receptacle, wherein steps i) and ii) are executed at least twice with discharge fractions from an execution of step c) and/or step f).