mhurhangee/ep-ind-claims huggingface dataset:
Process for the preparation of Droxidopa of formula or salt thereof: comprising the following steps: A) enzymatic reduction of a compound of formula: wherein R 1, R 2 are independently hydrogen or acetyl, R 3 is hydrogen or a C 1 -C 4 linear or branched alkyl group and R 4 is hydrogen or an amine protecting group; to give the compound of formula: wherein R 1, R 2, R 3, R 4 have the same meaning of above; by means of a ketoreductase enzyme; B) conversion of the compound of formula obtained in the step a) to Droxidopa of formula. A) enzymatic reduction of a compound of formula: wherein R 1, R 2 are independently hydrogen or acetyl, R 3 is hydrogen or a C 1 -C 4 linear or branched alkyl group and R 4 is hydrogen or an amine protecting group; to give the compound of formula: wherein R 1, R 2, R 3, R 4 have the same meaning of above; by means of a ketoreductase enzyme; wherein R 1, R 2 are independently hydrogen or acetyl, R 3 is hydrogen or a C 1 -C 4 linear or branched alkyl group and R 4 is hydrogen or an amine protecting group; to give the compound of formula: wherein R 1, R 2, R 3, R 4 have the same meaning of above; by means of a ketoreductase enzyme; B) conversion of the compound of formula obtained in the step a) to Droxidopa of formula.
Control method of the rotation speed of a turbine - centrifugal compressor group comprising a centrifugal compressor directly mechanically coupled to an expansion turbine (TorC) of an organic Rankine cycle system and at least a control system configured to control the power absorbed by the centrifugal compressor, wherein: - the control system is based on a first controller (PID-f) and a second controller (PID-s); - the centrifugal compressor is provided with a suction valve (Va) or stator blades having a variable mounting angle; and - the expansion turbine (TorC) is provided with an admission valve (Vi); said control method comprising following steps: - acting on the suction valve or variable mounting angle of the stator blades by means of the first controller (PID-f), in order to keep the rotation speed constant; - acting on the admission valve by means of the second controller (PID-s), in order to maintain the suction valve (Va) open or the mounting angle of the stator blades of the centrifugal compressor at values between the pumping limit of the centrifugal compressor and 100%, to ensure that the compressor remains in a stable operating condition. - the control system is based on a first controller (PID-f) and a second controller (PID-s); - the centrifugal compressor is provided with a suction valve (Va) or stator blades having a variable mounting angle; and - the expansion turbine (TorC) is provided with an admission valve (Vi); said control method comprising following steps: - acting on the suction valve or variable mounting angle of the stator blades by means of the first controller (PID-f), in order to keep the rotation speed constant; - acting on the admission valve by means of the second controller (PID-s), in order to maintain the suction valve (Va) open or the mounting angle of the stator blades of the centrifugal compressor at values between the pumping limit of the centrifugal compressor and 100%, to ensure that the compressor remains in a stable operating condition. - acting on the suction valve or variable mounting angle of the stator blades by means of the first controller (PID-f), in order to keep the rotation speed constant; - acting on the admission valve by means of the second controller (PID-s), in order to maintain the suction valve (Va) open or the mounting angle of the stator blades of the centrifugal compressor at values between the pumping limit of the centrifugal compressor and 100%, to ensure that the compressor remains in a stable operating condition.
A method for determining an energy efficient operation mode of a motor vehicle, wherein designated parameters of the actual operation mode of the motor vehicle are determined, parameters of the operation mode are compared to parameters of a consumption-optimized operation mode and by means of the comparison of the parameters, evaluation units for consumption-optimized operation mode are calculated, wherein a ratio of selected speed or acceleration to the selected gear speed is drawn upon as parameter of the actual operation mode, and wherein the journey of the motor vehicle is divided into sections with regard to time or distance, and wherein the evaluation units are calculated for the sections, and characterized in that the evaluation units are added to a value corresponding to the energy efficient operation mode, that the evaluation units are stored on a data carrier, and that the data carrier for the storage of the evaluation units is constructed as a structural unit with an authorization key for starting the motor vehicle.
A marine fall pipe system constructed for placing blocks of stone and/or rock on a seabed and configured for suspension from a marine vessel, the fall pipe system comprising a substantially tubular fall pipe having an open end for discharging the blocks of rock and/or stone, and the fall pipe system comprising an opening arrangement constructed such as to allow opening the substantially tubular fall pipe to provide an intermediate opening at a position along its length for discharging the blocks of stone and/or rock at said position from the fall pipe.
Sensor for detecting soot particles, comprising a substrate, a first electrode layer and, arranged between the substrate and the first electrode layer, a second electrode layer, wherein between the first electrode layer and the second electrode layer, an isolation layer is formed and in each of the first electrode layer and in the isolation layer at least one opening (15; 16) is provided, wherein the opening of the first electrode layer and the opening of the isolation layer are arranged at least in sections on top of each other in such a way that at least one passage to the second electrode layer is formed, wherein the at least one passage is in the form of a blind hole and wherein the blind hole extends at least over the isolation layer and over the first electrode layer, characterised in that a section of the second electrode layer is designed as the base of the blind hole and in that the blind hole has a quadratic cross-section with an area of 10 x 10 μm 2 - 100 x 100 μm 2.
A powder lubricant composition for hot metal working consisting of: a first component being one or more compounds selected from a group consisting of anhydride, pentahydrate, and decahydrate of sodium borate; optionally a second component being calcium carbonate and/or lithium carbonate; a third component being fatty acid sodium salt and/or fatty acid calcium salt; and a fourth component being a lamellar silicate compound, wherein the content ratio of each component, to total mass of said first to fourth components as 100%, is: 30 to 80 mass % of said first component; 0 to 15 mass % of said second component; 5 to 15 mass % of said third component; and 10 to 40 mass % of said fourth component. a first component being one or more compounds selected from a group consisting of anhydride, pentahydrate, and decahydrate of sodium borate; optionally a second component being calcium carbonate and/or lithium carbonate; a third component being fatty acid sodium salt and/or fatty acid calcium salt; and a fourth component being a lamellar silicate compound,
A method of controlling a combined plant to provide frequency support to a power grid operating at a variable grid frequency, the combined plant comprising at least one generator and an energy store and adapted to supply power to the power grid, the method comprising the steps of: charging the energy store at less than its rated power when frequency support is not needed; and when frequency support is needed, controlling the combined plant to increase or decrease the overall power that it supplies to the power grid; wherein in response to an increase in grid frequency, the combined plant is controlled to provide frequency support to the power grid by increasing the charging rate of the energy store so that it absorbs more power. charging the energy store at less than its rated power when frequency support is not needed; and when frequency support is needed, controlling the combined plant to increase or decrease the overall power that it supplies to the power grid;
A vehicle including an engine disposed in an engine compartment, a dashboard and a master cylinder operating mechanism provided in the vehicle, the master cylinder operating mechanism comprising: a cylinder body having an opening, the opening being at one end of the cylinder body; a guiding member engaged with the opening of the cylinder body, the guiding member being a member different from the cylinder body; a piston slidably accommodated inside the cylinder body and the guiding member; a pushrod connected to an end portion of the piston, the pushrod being configured to slide the piston in response to a pedal operating force generated by a driver; and a stopper member provided on an inner side of the guiding member, the stopper member being configured to restrict a sliding motion of the piston by coming into contact with the pushrod when the pushrod slides in a direction in which the pushrod is pulled out of the guiding member; and wherein a surface of the guiding member is in contact with the dashboard of the vehicle, the dashboard separating the engine compartment and a vehicle cabin from each other, and the surface of the guiding member in contact with the dashboard facing the engine compartment-side surface of the dashboard in the direction in which the pushrod is pulled out of the guiding member; characterised in that the cylinder body is secured to the dashboard with a clearance between the dashboard and the cylinder body. a cylinder body having an opening, the opening being at one end of the cylinder body; a guiding member engaged with the opening of the cylinder body, the guiding member being a member different from the cylinder body; a piston slidably accommodated inside the cylinder body and the guiding member; a pushrod connected to an end portion of the piston, the pushrod being configured to slide the piston in response to a pedal operating force generated by a driver; and a stopper member provided on an inner side of the guiding member, the stopper member being configured to restrict a sliding motion of the piston by coming into contact with the pushrod when the pushrod slides in a direction in which the pushrod is pulled out of the guiding member; and wherein a surface of the guiding member is in contact with the dashboard of the vehicle, the dashboard separating the engine compartment and a vehicle cabin from each other, and the surface of the guiding member in contact with the dashboard facing the engine compartment-side surface of the dashboard in the direction in which the pushrod is pulled out of the guiding member; characterised in that the cylinder body is secured to the dashboard with a clearance between the dashboard and the cylinder body.
A sprayable powder coating composition having a uniform particle size distribution comprising a particulate material made from a waterborne polyolefin dispersion comprising: (i) a base polymer, (ii) a polymeric coupling agent; (iii) a neutralizing agent; (iv) a fluid medium; and (v) optionally, a polymeric performance improving agent selected from the group consisting of functionalized polyethylene, functionalized polypropylene, non-functionalized copolymer of ethylene and propylene and any combination thereof, wherein the particle size distribution of the particulate material is from 20 to 300 micrometres; the particle size is measured with a Beckman Coulter LS 13 320 Laser Light Diffraction Particle Size Analyzer. (i) a base polymer, (ii) a polymeric coupling agent; (iii) a neutralizing agent; (iv) a fluid medium; and (v) optionally, a polymeric performance improving agent selected from the group consisting of functionalized polyethylene, functionalized polypropylene, non-functionalized copolymer of ethylene and propylene and any combination thereof,
Packaging, in particular packaging bag, preferably for receiving pourable and/or free-flowing products such as cement and the like, comprising at least one spun-bonded nonwoven or packaging spun-bonded nonwoven, characterized in that the spun-bonded nonwoven or packaging spun-bonded nonwoven comprises continuous filaments of thermoplastic material, that either the continuous filaments are monocomponent filaments and comprise at least 3 wt.%, preferably at least 4 wt.% of at least one filler for improving the weldability of the spun-bonded nonwoven - in particular for reducing the welding temperature during thermal welding of the spun-bonded nonwoven - or that the continuous filaments are formed from multicomponent filaments, in particular as bicomponent filaments and that a plastic component arranged on the surface of the multicomponent filaments or bicomponent filaments comprises at least 3 wt.%, preferably at least 4 wt.% of at least one filler for improving the weldability of the spun-bonded nonwoven - in particular for reducing the welding temperature during thermal welding of the spun-bonded nonwoven and that the spun-bonded nonwoven/packaging spun-bonded nonwoven forms the packaging wall and/or is part of the packaging wall and wherein sections of the spun-bonded nonwoven/packaging spun-bonded nonwoven in the side wall region and/or in the bottom region and/or in the top region of the packaging or the packaging wall are welded together. that either the continuous filaments are monocomponent filaments and comprise at least 3 wt.%, preferably at least 4 wt.% of at least one filler for improving the weldability of the spun-bonded nonwoven - in particular for reducing the welding temperature during thermal welding of the spun-bonded nonwoven - or that the continuous filaments are formed from multicomponent filaments, in particular as bicomponent filaments and that a plastic component arranged on the surface of the multicomponent filaments or bicomponent filaments comprises at least 3 wt.%, preferably at least 4 wt.% of at least one filler for improving the weldability of the spun-bonded nonwoven - in particular for reducing the welding temperature during thermal welding of the spun-bonded nonwoven
A topical pharmaceutical preparation consisting of a vasoconstrictor as the active agent in a pharmaceutically acceptable topical delivery vehicle, wherein the vasoconstrictor is norepinephrine, epinephrine, or a combination thereof, for use in the prophylactic treatment of chemotherapy-induced alopecia in a patient treated or to be treated with a chemotherapeutic agent.
A drive mechanism for an automated guided vehicle, comprising: a drive unit for propelling the automated guided vehicle and having a drive wheel and a drive motor that is operably coupled to the drive wheel via a drive transmission that couples power from the drive motor to the drive wheel to rotate the drive wheel about a drive axis; and a steering unit for steering the automated guided vehicle and having a steering motor, wherein the steering motor is coupled to the drive wheel to rotate the drive wheel about a steering axis; wherein both the drive motor and the steering motor are fixedly mounted so that they remain stationary relative to each other while the drive motor rotates the drive wheel about the drive axis to move the automated guided vehicle and the steering motor steers the drive wheel about the steering axis; characterised in that the drive transmission rotates about the steering axis along with the drive wheel under power from the steering motor; and wherein the steering axis extends through the drive wheel and the drive axis. a drive unit for propelling the automated guided vehicle and having a drive wheel and a drive motor that is operably coupled to the drive wheel via a drive transmission that couples power from the drive motor to the drive wheel to rotate the drive wheel about a drive axis; and a steering unit for steering the automated guided vehicle and having a steering motor, wherein the steering motor is coupled to the drive wheel to rotate the drive wheel about a steering axis; wherein both the drive motor and the steering motor are fixedly mounted so that they remain stationary relative to each other while the drive motor rotates the drive wheel about the drive axis to move the automated guided vehicle and the steering motor steers the drive wheel about the steering axis; characterised in that the drive transmission rotates about the steering axis along with the drive wheel under power from the steering motor; and wherein the steering axis extends through the drive wheel and the drive axis.
A non-therapeutic method for improving the trainability and/or cognitive function of a growing animal comprising feeding the animal a composition comprising: at least 10% by weight protein; at least 4% by weight fat; docosahexaenoic acid ("DHA") in an amount of from 0.05% to 0.4% by weight; and at least one antioxidant selected from the group consisting of at least 250 ppm vitamin E, at least 5 ppm vitamin C, at least 600 ppm taurine and at least 0.05 ppm beta-carotene. at least 10% by weight protein; at least 4% by weight fat; docosahexaenoic acid ("DHA") in an amount of from 0.05% to 0.4% by weight; and at least one antioxidant selected from the group consisting of at least 250 ppm vitamin E, at least 5 ppm vitamin C, at least 600 ppm taurine and at least 0.05 ppm beta-carotene.
An ex vivo method for maintaining the purity of a population of purified cardiomyocytes, the method comprising: culturing a population of purified cardiomyocytes obtained from an induced pluripotent stem (iPS) cell in a medium that is essentially free of serum or contains serum that is essentially free of low molecular weight molecules having a molecular weight of at most 10 kD, wherein the medium and the optionally contained serum is essentially free of glucose comprising an energy source other than glucose, wherein said population is cultured for at least one week and maintains the purity of cardiomyocytes. culturing a population of purified cardiomyocytes obtained from an induced pluripotent stem (iPS) cell in a medium that is essentially free of serum or contains serum that is essentially free of low molecular weight molecules having a molecular weight of at most 10 kD, wherein the medium and the optionally contained serum is essentially free of glucose comprising an energy source other than glucose, wherein said population is cultured for at least one week and maintains the purity of cardiomyocytes.
Rolling bearing unit, comprising two rolling bearings (4, 6), arranged one in another essentially in one radial plane, and a pair of eccentric rings arranged between the outer rolling bearing and the inner rolling bearing, the outer eccentric ring and the inner eccentric ring of the pair of eccentric rings being connected in each case to a dedicated rotary drive, characterized in that the rotary drive is designed in each case as an electric torque motor (22, 28) integrated structurally with the assigned eccentric ring (8, 10).
A method of processing object data for an apparatus, the apparatus being arranged to produce a three-dimensional object, the method comprising: receiving object data for a three-dimensional object; processing the object data to determine first data corresponding to a shell portion of the three-dimensional object and second data corresponding to a core portion of the three-dimensional object separate from the shell portion of the three-dimensional object characterised in that the method further comprises: halftoning the first data using error diffusion halftoning to generate control instructions for the apparatus to produce the shell portion of the three-dimensional object; and halftoning the second data using matrix halftoning to generate control instructions for the apparatus to produce the core portion of the three-dimensional object. receiving object data for a three-dimensional object; processing the object data to determine first data corresponding to a shell portion of the three-dimensional object and second data corresponding to a core portion of the three-dimensional object separate from the shell portion of the three-dimensional object characterised in that the method further comprises: halftoning the first data using error diffusion halftoning to generate control instructions for the apparatus to produce the shell portion of the three-dimensional object; and halftoning the second data using matrix halftoning to generate control instructions for the apparatus to produce the core portion of the three-dimensional object. halftoning the first data using error diffusion halftoning to generate control instructions for the apparatus to produce the shell portion of the three-dimensional object; and halftoning the second data using matrix halftoning to generate control instructions for the apparatus to produce the core portion of the three-dimensional object.
A method of installing a plaster edge strip for a plaster layer on a thermal insulation of a building, said plaster edge strip comprising a base portion which supports an expansion strip, and a trapping portion which in the trapping state restrains the expansion strip from expanding, said method comprising the following steps: (a) the plaster edge strip is inserted with its expansion strip into a gap between a previously built-in window frame or door frame and a previously applied thermal insulation, such that the side of the expansion strip directed away from the base portion faces the window frame or door frame, respectively; (b) the plaster edge strip in the installed state is fixed in its position by connection to the thermal insulation; (c) the trapping portion, either before or after installation of the plaster edge strip, is brought by a user into a release state releasing the expansion strip by removal of the trapping portion from the side of the expansion strip facing the window frame or door frame such that the expansion strip is capable of expanding in the direction away from the thermal insulation up to abutment against the window frame or door frame, respectively. (a) the plaster edge strip is inserted with its expansion strip into a gap between a previously built-in window frame or door frame and a previously applied thermal insulation, such that the side of the expansion strip directed away from the base portion faces the window frame or door frame, respectively; (b) the plaster edge strip in the installed state is fixed in its position by connection to the thermal insulation; (c) the trapping portion, either before or after installation of the plaster edge strip, is brought by a user into a release state releasing the expansion strip by removal of the trapping portion from the side of the expansion strip facing the window frame or door frame such that the expansion strip is capable of expanding in the direction away from the thermal insulation up to abutment against the window frame or door frame, respectively.