A method for secure upload and management of data from a plurality of contract research organizations to a centralized electronic laboratory notebook of a sponsor company, the method comprising: collecting, by a data loader of a sponsor company computing device, over a network, data from a plurality of contract research organizations for storage in the centralized electronic laboratory notebook of the sponsor company, wherein the data is collected from local electronic notebooks, each corresponding to a respective contract research organization, wherein (i) content of each of the local electronic notebooks is limited to content specific to the respective contract research organization, and (ii) the data loader is configured to block the contract research organizations from accessing the centralized electronic laboratory notebook of the sponsor company, and (iii) each of the local electronic notebooks comprises a server component, a local database, and a client component, wherein the client component is a front end application with which multiple users at the respective contract research organization interface in order to record the data, and data from the local database is of the same format as data in the centralized electronic laboratory notebook of the sponsor company or is converted by the data loader to a common format; and automatically synchronizing, by the sponsor company computing device, the data collected from the plurality of contract research organizations with data contained in the centralized electronic laboratory notebook of the sponsor company. collecting, by a data loader of a sponsor company computing device, over a network, data from a plurality of contract research organizations for storage in the centralized electronic laboratory notebook of the sponsor company, wherein the data is collected from local electronic notebooks, each corresponding to a respective contract research organization, wherein (i) content of each of the local electronic notebooks is limited to content specific to the respective contract research organization, and (ii) the data loader is configured to block the contract research organizations from accessing the centralized electronic laboratory notebook of the sponsor company, and (iii) each of the local electronic notebooks comprises a server component, a local database, and a client component, wherein the client component is a front end application with which multiple users at the respective contract research organization interface in order to record the data, and data from the local database is of the same format as data in the centralized electronic laboratory notebook of the sponsor company or is converted by the data loader to a common format; and the data is collected from local electronic notebooks, each corresponding to a respective contract research organization, wherein (i) content of each of the local electronic notebooks is limited to content specific to the respective contract research organization, and (ii) the data loader is configured to block the contract research organizations from accessing the centralized electronic laboratory notebook of the sponsor company, and (iii) each of the local electronic notebooks comprises a server component, a local database, and a client component, (i) content of each of the local electronic notebooks is limited to content specific to the respective contract research organization, and (ii) the data loader is configured to block the contract research organizations from accessing the centralized electronic laboratory notebook of the sponsor company, and (iii) each of the local electronic notebooks comprises a server component, a local database, and a client component, wherein the client component is a front end application with which multiple users at the respective contract research organization interface in order to record the data, and data from the local database is of the same format as data in the centralized electronic laboratory notebook of the sponsor company or is converted by the data loader to a common format; and the client component is a front end application with which multiple users at the respective contract research organization interface in order to record the data, and data from the local database is of the same format as data in the centralized electronic laboratory notebook of the sponsor company or is converted by the data loader to a common format; and automatically synchronizing, by the sponsor company computing device, the data collected from the plurality of contract research organizations with data contained in the centralized electronic laboratory notebook of the sponsor company.