A system for use in cardiac therapy evaluation comprising: electrode apparatus comprising a plurality of external electrodes (112, 202) to monitor electrical activity from tissue of a patient; and a computing apparatus comprising processing circuitry and operably coupled to the electrode apparatus, the computing apparatus configured to: monitor electrical activity using the plurality of external electrodes (112, 202), generate electrical heterogeneity information based on the monitored electrical activity, initiate delivery of pacing therapy using a plurality of different pacing vectors, wherein each different pacing vector uses a combination of pacing electrodes different from the remaining different pacing vectors, select one or more of the plurality of different pacing vectors based on the generated EHI from the electrical activity monitored during the delivery of pacing therapy using a plurality of different pacing vectors, initiate delivery of pacing therapy using the one or more selected different pacing vectors and a plurality of different settings of a pacing parameter, and identify one or more of the plurality of different settings of the pacing parameter based on the generated EHI from the electrical activity monitored during delivery of pacing therapy using the one or more selected different pacing vectors and the plurality of different settings of the pacing parameters. electrode apparatus comprising a plurality of external electrodes (112, 202) to monitor electrical activity from tissue of a patient; and a computing apparatus comprising processing circuitry and operably coupled to the electrode apparatus, the computing apparatus configured to: monitor electrical activity using the plurality of external electrodes (112, 202), generate electrical heterogeneity information based on the monitored electrical activity, initiate delivery of pacing therapy using a plurality of different pacing vectors, wherein each different pacing vector uses a combination of pacing electrodes different from the remaining different pacing vectors, select one or more of the plurality of different pacing vectors based on the generated EHI from the electrical activity monitored during the delivery of pacing therapy using a plurality of different pacing vectors, initiate delivery of pacing therapy using the one or more selected different pacing vectors and a plurality of different settings of a pacing parameter, and identify one or more of the plurality of different settings of the pacing parameter based on the generated EHI from the electrical activity monitored during delivery of pacing therapy using the one or more selected different pacing vectors and the plurality of different settings of the pacing parameters. monitor electrical activity using the plurality of external electrodes (112, 202), generate electrical heterogeneity information based on the monitored electrical activity, initiate delivery of pacing therapy using a plurality of different pacing vectors, wherein each different pacing vector uses a combination of pacing electrodes different from the remaining different pacing vectors, select one or more of the plurality of different pacing vectors based on the generated EHI from the electrical activity monitored during the delivery of pacing therapy using a plurality of different pacing vectors, initiate delivery of pacing therapy using the one or more selected different pacing vectors and a plurality of different settings of a pacing parameter, and identify one or more of the plurality of different settings of the pacing parameter based on the generated EHI from the electrical activity monitored during delivery of pacing therapy using the one or more selected different pacing vectors and the plurality of different settings of the pacing parameters.