A compound that is: 2-phenyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-phenylpiperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(o-tolyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2-fluorophenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 4-(4-(2-chlorophenyl)piperazin-1-yl)-2-cyclobutyl-6,7-dimethoxyquinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(2-pyridylphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(2-nitrophenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(3-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(4-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2,4-dimethoxyphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 2-cyclobutyl-4-(4-(2,6-dimethylphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 2-benzyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-ethyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-propylquinazoline; 2-isopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-isobutyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-vinylquinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclopentyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-(2-methylcyclopropyl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)quinazoline; 2-cyclobutyl-6-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-7-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6-cyclobutyl-8-(4-(2-methoxyphenyl)piperazin-1-yl)-[1,3]dioxolo[4,5-g]quinazoline; 2-cyclopropyl-6-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclopropyl-4-(4-(2-ethoxyphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 4-(4-(2-chlorophenyl)piperazin-1-yl)-2-cyclopropyl-6,7-dimethoxyquinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(4-methylbenzyl)piperazin-1-yl)quinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxybenzyl)piperazin-1-yl)quinazoline; (4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)(phenyl)methanone; (4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)(2-methoxyphenyl)methanone; or a pharmaceutically acceptable salt, solvate, tautomer, or N-oxide thereof. 2-phenyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-phenylpiperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(o-tolyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2-fluorophenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 4-(4-(2-chlorophenyl)piperazin-1-yl)-2-cyclobutyl-6,7-dimethoxyquinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(2-pyridylphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(2-nitrophenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(3-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-6,7-dimethoxy-4-(4-(4-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2,4-dimethoxyphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 2-cyclobutyl-4-(4-(2,6-dimethylphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 2-benzyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-ethyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-propylquinazoline; 2-isopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-isobutyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-vinylquinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclopentyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-(2-methylcyclopropyl)quinazoline; 6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)quinazoline; 2-cyclobutyl-6-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-7-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclobutyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 6-cyclobutyl-8-(4-(2-methoxyphenyl)piperazin-1-yl)-[1,3]dioxolo[4,5-g]quinazoline; 2-cyclopropyl-6-methoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline; 2-cyclopropyl-4-(4-(2-ethoxyphenyl)piperazin-1-yl)-6,7-dimethoxyquinazoline; 4-(4-(2-chlorophenyl)piperazin-1-yl)-2-cyclopropyl-6,7-dimethoxyquinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(4-methylbenzyl)piperazin-1-yl)quinazoline; 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxybenzyl)piperazin-1-yl)quinazoline; (4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)(phenyl)methanone; (4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl)(2-methoxyphenyl)methanone;