mhurhangee/ep-ind-claims huggingface dataset:
A solid composition for use in a method of treating HCV infection, said composition comprising a compound, or a pharmaceutically acceptable salt thereof, in an amorphous form, a pharmaceutically acceptable hydrophilic polymer; and optionally a pharmaceutically acceptable surfactant, wherein said compound is selected from the group consisting of: dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-((2S,5S)-1-(4- tert -butylphenyl)pyrrolidine-2,5-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate (Compound I A), methyl [ -1-{ -2-[4-(4-{5-(4-{2-[ -1-{ -2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1-[6-(piperidin-1-yl)pyridin-3-yl]-1H-pyrrol-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}-3-methyl-1-oxobutan-2-yl]carbamate (Compound I B), methyl {(2 S,3 R)-1-[(2 S)-2-{6-[(2 R,5 R)-1-(4- tert -butylphenyl)-5-(2-{(2 S)-1-[ N- (methoxycarbonyl)- O -methyl-L-threonyl]pyrrolidin-2-yl}-1 H -benzimidazol-6-yl)pyrrolidin-2-yl]-1 H -benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate (Compound I C), and methyl { -1-[ -2-{5-[(2R,5R)-1-[2,5-difluoro-4-(trifluoromethyl)phenyl]-5-{2-[ -1-{ -2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}pyrrolidin-2-yl]-1H-benzimidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I D), and wherein said compound or salt, and said polymer, are in a solid dispersion. a compound, or a pharmaceutically acceptable salt thereof, in an amorphous form, a pharmaceutically acceptable hydrophilic polymer; and optionally a pharmaceutically acceptable surfactant, dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-((2S,5S)-1-(4- tert -butylphenyl)pyrrolidine-2,5-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate (Compound I A), methyl [ -1-{ -2-[4-(4-{5-(4-{2-[ -1-{ -2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1-[6-(piperidin-1-yl)pyridin-3-yl]-1H-pyrrol-2-yl}phenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}-3-methyl-1-oxobutan-2-yl]carbamate (Compound I B), methyl {(2 S,3 R)-1-[(2 S)-2-{6-[(2 R,5 R)-1-(4- tert -butylphenyl)-5-(2-{(2 S)-1-[ N- (methoxycarbonyl)- O -methyl-L-threonyl]pyrrolidin-2-yl}-1 H -benzimidazol-6-yl)pyrrolidin-2-yl]-1 H -benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate (Compound I C), and methyl { -1-[ -2-{5-[(2R,5R)-1-[2,5-difluoro-4-(trifluoromethyl)phenyl]-5-{2-[ -1-{ -2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}pyrrolidin-2-yl]-1H-benzimidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I D), and wherein said compound or salt, and said polymer, are in a solid dispersion.
Use of Sapindus mukurossi peel extract for preventing or improving wrinkles by inhibiting the activity of heparanase present in skin by external application.
A method for the production of an electronic module, comprising: - providing a carrier substrate equipped with a first electronic component, wherein the carrier substrate has a primary layer, a secondary layer and a metallic intermediate layer arranged between the primary layer and the secondary layer, wherein in order to form a sandwich structure, the metallic intermediate layer spaces the primary layer from the secondary layer, wherein the primary layer has at least one first recess, - at least partially encapsulating the assembled carrier substrate with an encapsulation, - realising a second recess in the encapsulation and - forming a via for providing an electrical connection between a second electronic component on an outer side of the encapsulation and the metallic intermediate layer, wherein the first recess in the primary layer and the second recess in the encapsulation are filled together with an electrically conductive material in a single step, wherein the metallic intermediate layer arranged between the primary layer and the secondary layer extends over a first area in a plane running parallel to the main extension plane and the primary layer and/or the second secondary layer extends over a second area, wherein a ratio of the first area to the second area is greater than 0.5, preferably greater than 0.75 and most preferably greater than 0.9. - providing a carrier substrate equipped with a first electronic component, wherein the carrier substrate has a primary layer, a secondary layer and a metallic intermediate layer arranged between the primary layer and the secondary layer, wherein in order to form a sandwich structure, the metallic intermediate layer spaces the primary layer from the secondary layer, wherein the primary layer has at least one first recess, - at least partially encapsulating the assembled carrier substrate with an encapsulation, - realising a second recess in the encapsulation and - forming a via for providing an electrical connection between a second electronic component on an outer side of the encapsulation and the metallic intermediate layer, wherein the first recess in the primary layer and the second recess in the encapsulation are filled together with an electrically conductive material in a single step, wherein the metallic intermediate layer arranged between the primary layer and the secondary layer extends over a first area in a plane running parallel to the main extension plane and the primary layer and/or the second secondary layer extends over a second area, wherein a ratio of the first area to the second area is greater than 0.5, preferably greater than 0.75 and most preferably greater than 0.9.
A method implemented by computer means for monitoring the visual behavior of a person, the method comprises: - a person activity data providing step during which person activity data indicative of an activity of the person are provided, - a person visual behavior data providing step during which person visual behavior data indicative of the visual behavior of the person related to said activity of the person are provided, - an environment data providing step during which environment data indicative to the environment of the person are provided, - reference visual behavior providing step during which a reference visual behavior data indicative of the reference visual behavior of the person based on said activity of the person and the environment data are provided, - a comparing step during which the person visual behavior data and the reference visual behavior data are compared so as to deduce whether the person visual behavior is adapted with respect to said activity of the person, characterised in that the environment data corresponds to temperature and/or humidity of the environment, and/or the amount and/or type of allergens and/or pollutants contained in the environment. - a person activity data providing step during which person activity data indicative of an activity of the person are provided, - a person visual behavior data providing step during which person visual behavior data indicative of the visual behavior of the person related to said activity of the person are provided, - an environment data providing step during which environment data indicative to the environment of the person are provided, - reference visual behavior providing step during which a reference visual behavior data indicative of the reference visual behavior of the person based on said activity of the person and the environment data are provided, - a comparing step during which the person visual behavior data and the reference visual behavior data are compared so as to deduce whether the person visual behavior is adapted with respect to said activity of the person,
Neutron generator (2, 68, 70, 80), comprising: ▪ a vacuum container with a first end and a second end, ▪ at least one ion source (16, 44) at the first end and/or the second end with a gas inlet (19, 48), an ion outlet (20, 50), an anode (18, 52) and an extraction cathode (24, 54), and ▪ a central high-voltage electrode (38, 76, 86), ▪ wherein the ion outlet (20, 50) is designed as a capillary ▪ wherein the extraction cathode (24, 54) for extracting ions from the ion outlet (20, 50) is arranged downstream of the ion outlet (20, 50) ▪ wherein the central high-voltage electrode (38, 76, 86) is arranged between the first end and the second end of the vacuum container and has at least one bore (40, 78, 88), ▪ wherein the central high-voltage electrode (38, 76, 86) is arranged between the first end and the second end in such a way that ions emitted from a respective ion source (16, 44) at the first end or the second end pass through the at least one bore (40, 78, 88) of the central high-voltage electrode (38, 76, 86) and, before reaching the opposite end (6, 8), reverse their direction of flight by action of the central high-voltage electrode (38, 76, 86) and collide with ions from the relevant ion source (16, 44), characterized in that the neutron generator further comprises at least one guide capillary made of an insulating material extending from at least one ion outlet (20, 50) to the central high-voltage electrode (38, 76, 86). ▪ a vacuum container with a first end and a second end, ▪ at least one ion source (16, 44) at the first end and/or the second end with a gas inlet (19, 48), an ion outlet (20, 50), an anode (18, 52) and an extraction cathode (24, 54), and ▪ a central high-voltage electrode (38, 76, 86), ▪ wherein the ion outlet (20, 50) is designed as a capillary ▪ wherein the extraction cathode (24, 54) for extracting ions from the ion outlet (20, 50) is arranged downstream of the ion outlet (20, 50) ▪ wherein the central high-voltage electrode (38, 76, 86) is arranged between the first end and the second end of the vacuum container and has at least one bore (40, 78, 88), ▪ wherein the central high-voltage electrode (38, 76, 86) is arranged between the first end and the second end in such a way that ions emitted from a respective ion source (16, 44) at the first end or the second end pass through the at least one bore (40, 78, 88) of the central high-voltage electrode (38, 76, 86) and, before reaching the opposite end (6, 8), reverse their direction of flight by action of the central high-voltage electrode (38, 76, 86) and collide with ions from the relevant ion source (16, 44),
A method of handover performed by a wireless transmit/receive unit, WTRU, (110;302;402;502) the method comprising: receiving a handover command (314;414;514) from a second evolved Node B, eNB, associated with a source cell, the handover command including a specific configuration of a first eNB associated with a target cell; characterized by performing limited operations within the target cell that do not require a system frame number, SFN, of the first eNB, where a layer 1, L1, feedback report is disabled during the limited operations; initiating reception and processing of a primary broadcast channel, P-BCH, of the first eNB after receiving the handover command; receiving the SFN of the first eNB over the P-BCH; and performing normal operations within the target cell, wherein at least one of the normal operations utilizes the SFN of the first eNB and the at least one of the normal operations includes activating the L1 feedback report. receiving a handover command (314;414;514) from a second evolved Node B, eNB, associated with a source cell, the handover command including a specific configuration of a first eNB associated with a target cell; characterized by performing limited operations within the target cell that do not require a system frame number, SFN, of the first eNB, where a layer 1, L1, feedback report is disabled during the limited operations; initiating reception and processing of a primary broadcast channel, P-BCH, of the first eNB after receiving the handover command; receiving the SFN of the first eNB over the P-BCH; and performing normal operations within the target cell, wherein at least one of the normal operations utilizes the SFN of the first eNB and the at least one of the normal operations includes activating the L1 feedback report.
Fuel injection device for an internal combustion engine, having a fuel predelivery pump which delivers fuel from a fuel tank via a pressure-side delivery line to a high-pressure fuel pump, characterized in that the predelivery pump has a drive which is independent of the high-pressure pump and which is in particular electric, and in that the pressure-side delivery line is connected by way of an electrically actuated flow rate differential valve with adjustable valve cross section to a return line, wherein the predelivery pump is regulated in terms of pressure by way of the fuel pressure prevailing in its pressure-side delivery line, or is regulated in terms of flow rate by way of the delivered fuel flow rate.
An inter-network communication controller comprising processing circuitry configured to: receive location information associated with an in-flight aircraft being tracked and provided with air-to-ground, ATG, wireless communication services by a first ATG network comprising a first set of two or more ATG base stations (100,110) that share a common backhaul, the first ATG network employing beamforming directed to the aircraft to provide the communication services; and provide the location information to a second ATG network comprising a second set of two or more ATG base stations (130, 140) that do not share the common backhaul of the first set of two or more ATG base stations to enable the second ATG network to utilize the location information for employing beamforming to establish wireless communication with the aircraft, wherein the first ATG network and the second ATG network each operate over different ranges of radio frequency, RF, spectrum. receive location information associated with an in-flight aircraft being tracked and provided with air-to-ground, ATG, wireless communication services by a first ATG network comprising a first set of two or more ATG base stations (100,110) that share a common backhaul, the first ATG network employing beamforming directed to the aircraft to provide the communication services; and provide the location information to a second ATG network comprising a second set of two or more ATG base stations (130, 140) that do not share the common backhaul of the first set of two or more ATG base stations to enable the second ATG network to utilize the location information for employing beamforming to establish wireless communication with the aircraft, wherein the first ATG network and the second ATG network each operate over different ranges of radio frequency, RF, spectrum.
A side curtain airbag for a motor vehicle which is deployable from a motor vehicle ceiling or a motor vehicle side window sill, the airbag comprising a first inflatable portion (101, 201) configured when inflated to cover and be in spaced alignment with a side window: characterized in that, when the airbag is deployed, an outboard panel of the first inflatable portion adopts a profile curving into the motor vehicle passenger compartment, wherein the outboard panel comprises one or more horizontal pleats.
A fixed-bed reactor comprising: a first catalyst layer filled with a first catalyst for producing acrolein from propylene; a second catalyst layer filled with a second catalyst for producing acrylic acid from acrolein; and an inert substance layer provided between the first catalyst layer and the second catalyst layer, and filled with an inert substance of a cylindrical shape having a surrounding wall in which an opening is formed, wherein the opening is formed by removing a part of the surrounding wall and no structure is present inside the inner surface and outside the outer surface of the surrounding wall a first catalyst layer filled with a first catalyst for producing acrolein from propylene; a second catalyst layer filled with a second catalyst for producing acrylic acid from acrolein; and an inert substance layer provided between the first catalyst layer and the second catalyst layer, and filled with an inert substance of a cylindrical shape having a surrounding wall in which an opening is formed, wherein the opening is formed by removing a part of the surrounding wall and no structure is present inside the inner surface and outside the outer surface of the surrounding wall
Method for operating an electric circuit, wherein the electric circuit is provided with a power converter having at least one series circuit (11, 12, 13) that is connected to a terminal P(+) for a positive potential and to a terminal M(-) for a negative potential, and each series circuit (11, 12, 13) consists of four power semiconductor elements, wherein the connection point of the two middle power semiconductor elements forms a terminal for an alternating voltage, and wherein the electric circuit is provided with at least two series-connected capacitors (Cdl, Cd2) which are connected in parallel with the series circuit (11, 12, 13) and wherein the series-connected capacitors are connected at one end to the terminal P(+) and at the other end to the terminal M(-) and the connection point of the capacitors (Cdl, Cd2) forms a third terminal for a zero potential, two series-connected diodes (D5, D6) being connected in parallel in opposite senses to the central two power semiconductor elements, the connection point of which is connected to the connection point of the two capacitors (Cdl, Cd2), at least one resistor being connected in parallel to the central two power semiconductor elements, characterised in that in the method at least one of the two outer power semiconductor elements is conductively connected and in this way a discharge current is generated from the at least one capacitor (Cdl, Cd2) via the at least one conductively connected power semiconductor element and the resistor.
An apparatus for handling articles, such as bundles, piece goods, or the like, comprising: - an upper suspension, to which at least three rotatably driven positioning arms are fastened, wherein the at least three rotatably driven positioning arms each consist of at least two arm sections (7, 9) that are swivelable relative to each other and that can be operated independently of one another; - a manipulator that comprises one or more means for gripping the articles and that is mechanically coupled to the at least three positioning arms such that a position of the manipulator can be specified by a movement of one or more of the at least three positioning arms; - at least one drive shaft that is linked non-rotatingly to the manipulator such that the manipulator can be rotated by the at least one drive shaft; and - at least one actuating shaft by way of which the one or more means for temporarily gripping and releasing articles can be controlled; and characterized by - at least one driving member which is linked non-rotatingly to the at least one drive shaft and by which a mechanical coupling is formed between the at least one drive shaft and the at least one actuating shaft, with the mechanical coupling serving for rotatingly driving along the at least one actuating shaft about the longitudinal axis of the at least one drive shaft. - an upper suspension, to which at least three rotatably driven positioning arms are fastened, wherein the at least three rotatably driven positioning arms each consist of at least two arm sections (7, 9) that are swivelable relative to each other and that can be operated independently of one another; - a manipulator that comprises one or more means for gripping the articles and that is mechanically coupled to the at least three positioning arms such that a position of the manipulator can be specified by a movement of one or more of the at least three positioning arms; - at least one drive shaft that is linked non-rotatingly to the manipulator such that the manipulator can be rotated by the at least one drive shaft; and - at least one actuating shaft by way of which the one or more means for temporarily gripping and releasing articles can be controlled; and characterized by - at least one driving member which is linked non-rotatingly to the at least one drive shaft and by which a mechanical coupling is formed between the at least one drive shaft and the at least one actuating shaft, with the mechanical coupling serving for rotatingly driving along the at least one actuating shaft about the longitudinal axis of the at least one drive shaft.
A phosphor wheel (300, 400), comprising: an annular disc (310, 410); a light-emitting area (320, 420) along an outer perimeter of the disc that defines an exposed annular sector (305, 405) of the disc; a hub (330, 430) coupled along an inner perimeter of the disc; and a balancing piece (340, 440) attached to a front surface of the disc radially inward from the exposed annular sector (305, 405) for minimizing imbalance of the phosphor wheel (300, 400), characterized in that the balancing piece (340, 440) has one of: a shape of a first annular sector having a first central angle that is joined to a second annular sector further away from the hub having a second central angle, wherein the first central angle is greater than the second central angle, or a first portion and a second portion, wherein the first portion is in a shape of an annulus placed between the annular disc and the hub, and the second portion extends outwardly from the first portion toward the exposed annular sector of the annular disc. an annular disc (310, 410); a light-emitting area (320, 420) along an outer perimeter of the disc that defines an exposed annular sector (305, 405) of the disc; a hub (330, 430) coupled along an inner perimeter of the disc; and a balancing piece (340, 440) attached to a front surface of the disc radially inward from the exposed annular sector (305, 405) for minimizing imbalance of the phosphor wheel (300, 400), characterized in that the balancing piece (340, 440) has one of: a shape of a first annular sector having a first central angle that is joined to a second annular sector further away from the hub having a second central angle, wherein the first central angle is greater than the second central angle, or a first portion and a second portion, wherein the first portion is in a shape of an annulus placed between the annular disc and the hub, and the second portion extends outwardly from the first portion toward the exposed annular sector of the annular disc. a shape of a first annular sector having a first central angle that is joined to a second annular sector further away from the hub having a second central angle, wherein the first central angle is greater than the second central angle, or a first portion and a second portion, wherein the first portion is in a shape of an annulus placed between the annular disc and the hub, and the second portion extends outwardly from the first portion toward the exposed annular sector of the annular disc.