A compound having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein: X is -O-, -S 0-2 -, -C(=O)-, -C(OR 5) 2 -, -C(OR 5)(OC(=O)R 13)-, -C(R 8 R 9)-, -C(=CR 8 R 9)-, -N(R 9)-, -N(COR 9)-, -CHNR 8 R 9 -, -C(=NR 9)-, -C(=NOR 5)-, or -C(=N-NHR 5)-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13; R 3 is 5-6 membered heteroaryl or 3-7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl comprises at least one N atom in the ring and wherein said heteroaryl or said heterocyclyl are optionally substituted with one or more R 6; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 6 is each independently selected from the group consisting of H, F, CI, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl, wherein each R 6 is optionally substituted with one or more of halogen, 123 I, 18 F, hydroxyl, -OS 2 -aryl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S 0-2 R 5, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5, or R 8 and R 9 can join to form a unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a, R 11b, R 11c and R 11d are each independently H, F, CI, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; -OR 5, -OC(=O)R 13, C 1 -C 10 acyl, -S 0-2 R 5, -NO 2, -CN, -NH 2, -NHR 5, or -N(R 5) 2; R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; and n 3 is 0, 1, 2, 3, 4, or 5; wherein at least one of R 11a, R 11b, R 11c and R 11d is CI, Br, I or 123 I. X is -O-, -S 0-2 -, -C(=O)-, -C(OR 5) 2 -, -C(OR 5)(OC(=O)R 13)-, -C(R 8 R 9)-, -C(=CR 8 R 9)-, -N(R 9)-, -N(COR 9)-, -CHNR 8 R 9 -, -C(=NR 9)-, -C(=NOR 5)-, or -C(=N-NHR 5)-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13; R 3 is 5-6 membered heteroaryl or 3-7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl comprises at least one N atom in the ring and wherein said heteroaryl or said heterocyclyl are optionally substituted with one or more R 6; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 6 is each independently selected from the group consisting of H, F, CI, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl, wherein each R 6 is optionally substituted with one or more of halogen, 123 I, 18 F, hydroxyl, -OS 2 -aryl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S 0-2 R 5, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5, or R 8 and R 9 can join to form a unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a, R 11b, R 11c and R 11d are each independently H, F, CI, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; -OR 5, -OC(=O)R 13, C 1 -C 10 acyl, -S 0-2 R 5, -NO 2, -CN, -NH 2, -NHR 5, or -N(R 5) 2; R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; and n 3 is 0, 1, 2, 3, 4, or 5; wherein at least one of R 11a, R 11b, R 11c and R 11d is CI, Br, I or 123 I.