An injector comprising: a container (452, 602, 650, 720) including a wall (460, 604, 652, 722) with an interior surface (462, 668, 738) and a seal assembly with an interior surface (494, 658, 728), the interior surfaces of the wall (460, 604, 652, 722) and the seal assembly defining a closed sterile reservoir (510, 670, 740), wherein the wall (460, 604, 652, 722) of the container (452, 602, 650, 720) defines a bore (480, 606) including the sterile reservoir (510, 670, 740); a volume of a drug product (520, 680, 750) disposed in the sterile reservoir (510, 670, 740), the drug product (520, 680, 750) comprising a granulocyte colony-stimulating factor (G-CSF); a fluid delivery system (454, 700) comprising a container needle (550, 702, 772) having a point (552, 704, 774), the point (552, 704, 774) only partially disposed through the seal assembly in a storage state, and disposed through the seal assembly and into the sterile reservoir (510, 670, 740) in a delivery state; and an actuator that is adapted to move the container needle (550, 702, 772) from the storage state to the delivery state; characterized in that the seal assembly comprises a flexible wall (490, 608, 654, 724) with an interior surface that defines the interior surface (494, 658, 728) of the seal assembly, and a clean barrier (492, 610, 656, 726) disposed exterior of the flexible wall (490, 608, 654, 724) to define an enclosed clean space (530, 690, 760) between the flexible wall (490, 608, 654, 724) and the clean barrier (492, 610, 656, 726), the point (552, 704, 774) of the container needle (550, 702, 772) disposed through the clean barrier (492, 610, 656, 726) into the clean space (530, 690, 760) in the storage state and disposed through the flexible wall (490, 608, 654, 724) into the sterile reservoir (510, 670, 740) in a delivery state. wherein a stopper or the flexible wall as stopper (608, 654, 724) is disposed within the bore (480, 606) and movable along the bore (480, 606); a container (452, 602, 650, 720) including a wall (460, 604, 652, 722) with an interior surface (462, 668, 738) and a seal assembly with an interior surface (494, 658, 728), the interior surfaces of the wall (460, 604, 652, 722) and the seal assembly defining a closed sterile reservoir (510, 670, 740), wherein the wall (460, 604, 652, 722) of the container (452, 602, 650, 720) defines a bore (480, 606) including the sterile reservoir (510, 670, 740); a volume of a drug product (520, 680, 750) disposed in the sterile reservoir (510, 670, 740), the drug product (520, 680, 750) comprising a granulocyte colony-stimulating factor (G-CSF); a fluid delivery system (454, 700) comprising a container needle (550, 702, 772) having a point (552, 704, 774), the point (552, 704, 774) only partially disposed through the seal assembly in a storage state, and disposed through the seal assembly and into the sterile reservoir (510, 670, 740) in a delivery state; and an actuator that is adapted to move the container needle (550, 702, 772) from the storage state to the delivery state; characterized in that the seal assembly comprises a flexible wall (490, 608, 654, 724) with an interior surface that defines the interior surface (494, 658, 728) of the seal assembly, and a clean barrier (492, 610, 656, 726) disposed exterior of the flexible wall (490, 608, 654, 724) to define an enclosed clean space (530, 690, 760) between the flexible wall (490, 608, 654, 724) and the clean barrier (492, 610, 656, 726), the point (552, 704, 774) of the container needle (550, 702, 772) disposed through the clean barrier (492, 610, 656, 726) into the clean space (530, 690, 760) in the storage state and disposed through the flexible wall (490, 608, 654, 724) into the sterile reservoir (510, 670, 740) in a delivery state. wherein a stopper or the flexible wall as stopper (608, 654, 724) is disposed within the bore (480, 606) and movable along the bore (480, 606);