A method for producing and packaging and documenting the removal of a plurality of medicaments comprising a predetermined active substance and for simultaneously providing an active substance value (c) indicating an active substance quantity contained in the medicament, - wherein for the active substance quantity, to be determined in each case, of the medicament, a standard value (c N) and a maximum deviation (Δc) from said standard value (c N) are predetermined, wherein an active substance value (c) within the range c N +/-Δc is selected or predetermined and an active substance quantity corresponding to the active substance value (c) is used for producing said medicament, - wherein the active substance value (c) produced is associated with the medicament and is kept available together with the medicament after the production of same, - wherein the produced medicament is inserted, after it has been produced, into a predetermined pocket of a medicament blister, in particular of a medicament blister, - wherein the active substance value (c) associated with the medicament and a key (k 1,..., k n) characterising a predetermined pocket of the medicament blister are transferred together to a memory disposed preferably on a controller which is disposed on the medicament blister, and - wherein a key (k 1,..., k n) characterising a pocket and an active substance quantity (c 1,..., c n) of the medicament disposed in said pocket are kept available for retrieval, in particular by the controller, - wherein the pockets of the medicament blister containing the medicaments are closed after the medicaments are inserted, and a pocket is opened by the patient before the medicament is taken, - wherein the opening of a pocket is detected by the controller disposed on the medicament blister, - wherein an active substance value (c) of the medicament disposed in the last-opened pocket is kept available separately and/or additionally, in particular by the controller, and - wherein optionally an active substance value (c) is transferred to a documentation server, wherein said active substance value (c) is stored together with an output time in a documentation memory, associated with a patient, of the documentation server. - wherein for the active substance quantity, to be determined in each case, of the medicament, a standard value (c N) and a maximum deviation (Δc) from said standard value (c N) are predetermined, wherein an active substance value (c) within the range c N +/-Δc is selected or predetermined and an active substance quantity corresponding to the active substance value (c) is used for producing said medicament, - wherein the active substance value (c) produced is associated with the medicament and is kept available together with the medicament after the production of same, - wherein the produced medicament is inserted, after it has been produced, into a predetermined pocket of a medicament blister, in particular of a medicament blister, - wherein the active substance value (c) associated with the medicament and a key (k 1,..., k n) characterising a predetermined pocket of the medicament blister are transferred together to a memory disposed preferably on a controller which is disposed on the medicament blister, and - wherein a key (k 1,..., k n) characterising a pocket and an active substance quantity (c 1,..., c n) of the medicament disposed in said pocket are kept available for retrieval, in particular by the controller, - wherein the pockets of the medicament blister containing the medicaments are closed after the medicaments are inserted, and a pocket is opened by the patient before the medicament is taken, - wherein the opening of a pocket is detected by the controller disposed on the medicament blister, - wherein an active substance value (c) of the medicament disposed in the last-opened pocket is kept available separately and/or additionally, in particular by the controller, and - wherein optionally an active substance value (c) is transferred to a documentation server, wherein said active substance value (c) is stored together with an output time in a documentation memory, associated with a patient, of the documentation server.