mhurhangee/ep-ind-claims huggingface dataset:
An antibody that binds CSF1R for use in a method of treatment of pigmented villonodular synovitis (PVNS) in a subject, wherein the subject experiences one or more than one of (a) a reduction in joint pain, (b) an increased range of motion in a joint, and (c) an increase in functional capacity of a joint, and wherein the antibody is selected from: a) an antibody comprising a heavy chain comprising the sequence of SEQ ID NO: 39 and a light chain comprising the sequence of SEQ ID NO: 46; b) an antibody comprising a heavy chain comprising a heavy chain CDR1 having the sequence of SEQ ID NO: 15, an HC CDR2 having the sequence of SEQ ID NO: 16, and an HC CDR3 having the sequence of SEQ ID NO: 17, and a light chain comprising a light chain CDR1 having the sequence of SEQ ID NO: 18, a LC CDR2 having the sequence of SEQ ID NO: 19, and a LC CDR3 having the sequence of SEQ ID NO: 20; and c) an antibody comprising a heavy chain comprising the sequence of SEQ ID NO: 53 and a light chain comprising the sequence of SEQ ID NO: 60, and wherein the method comprises administering 1 mg/kg, 2 mg/kg, 3 mg/kg, or 4 mg/kg of the antibody to the subject. a) an antibody comprising a heavy chain comprising the sequence of SEQ ID NO: 39 and a light chain comprising the sequence of SEQ ID NO: 46; b) an antibody comprising a heavy chain comprising a heavy chain CDR1 having the sequence of SEQ ID NO: 15, an HC CDR2 having the sequence of SEQ ID NO: 16, and an HC CDR3 having the sequence of SEQ ID NO: 17, and a light chain comprising a light chain CDR1 having the sequence of SEQ ID NO: 18, a LC CDR2 having the sequence of SEQ ID NO: 19, and a LC CDR3 having the sequence of SEQ ID NO: 20; and c) an antibody comprising a heavy chain comprising the sequence of SEQ ID NO: 53 and a light chain comprising the sequence of SEQ ID NO: 60, and
An antibody or antigen-binding fragment thereof, which is specific for human CD3, comprising a variable light chain with a sequence according to SEQ ID NO: 4, and a variable heavy chain with a sequence according to SEQ ID NO: 8.
A method for fixing a rebound mat to a trampoline frame comprising the steps of: a) providing a plurality of elastic elements and connectors, b) looping a section of the trampoline frame with a rope loop formed from the at least one elastic element, c) mounting the free ends of the elastic elements in one of the connectors, d) mounting a tension band in the connector connected to the free ends of the elastic elements, e) repeating steps b) to d) for all elastic elements provided along the circumference of the trampoline frame, characterised in that the step of mounting the tension band is divided into d1) passing a loop of the tension band through a second seat (201, 202; 211, 212; 251, 252; 1251) of the connector (200, 1230), the second seat having a larger opening on the side facing the trampoline frame than opposite on the inwardly facing side, d2) inserting a retaining element into the loop of the tension band projecting through the second receptacle, and d3) retracting the loop with the retaining element inserted therein until the position of the loop of the tension band is locked to the connector (200, 1230). a) providing a plurality of elastic elements and connectors, b) looping a section of the trampoline frame with a rope loop formed from the at least one elastic element, c) mounting the free ends of the elastic elements in one of the connectors, d) mounting a tension band in the connector connected to the free ends of the elastic elements, e) repeating steps b) to d) for all elastic elements provided along the circumference of the trampoline frame, d1) passing a loop of the tension band through a second seat (201, 202; 211, 212; 251, 252; 1251) of the connector (200, 1230), the second seat having a larger opening on the side facing the trampoline frame than opposite on the inwardly facing side, d2) inserting a retaining element into the loop of the tension band projecting through the second receptacle, and d3) retracting the loop with the retaining element inserted therein until the position of the loop of the tension band is locked to the connector (200, 1230).
Method of measuring a layer thickness (d) or a distance of a measurement object (2, 102) with terahertz radiation, in the case of which at least one terahertz beam is radiated from a terahertz transmission and receiving unit along an optical axis onto the measurement object (2, 102) and terahertz radiation entering and reflected through or onto at least one layer of the measurement object (2, 102) is detected, wherein a measurement signal of the detected and reflected terahertz radiation is evaluated and the layer thickness (d) and/or the distance is determined from a travel time difference (t2-t1) of the radiation reflected on at least one boundary surface (2a, 2b) of the layer, wherein a plurality of measurements are carried out with different optical axes, wherein the optical axis of the emitted terahertz radiation is adjusted during the measurements or between the measurements and one of the plurality of measurements is used to calculate the layer thickness (d) and/or the distance, wherein the optical axis of the emitted terahertz radiation is adjusted continuously or consistently or periodically over an adjustment range (α, s) and a plurality of measurements are recorded during the adjustment, wherein the plurality of measurements are compared with one another and one measurement with a maximum measurement signal is used as a measurement to calculate the layer thickness (d) and/or the distance.
Artificial neuron (1; 1') comprising: - a capacitance, called membrane capacitance (Cm), - an input, called external synaptic excitation current (I ex), the membrane capacitance (Cm) integrating this input current, - a negative feedback pulse circuit supplied by a power supply (Vs, Vd) at negative voltage (Vs) lying between -200 mV and 0 mV and at positive voltage (Vd) lying between 0 mV and + 200 mV, consisting of: o a bridge based on PMOS and NMOS transistors in series and connected, at the drains thereof, by a midpoint to the membrane capacitance (Cm), this midpoint defining the output of the artificial neuron (1; 1'), o at least one capacitance, called delay capacitance (Cna, Ck), between the gate and the source of one of the transistors (7, 8) of the bridge, - only two CMOS inverters (5, 6) connected in a cascade-like manner, each being composed of two transistors, the input of the first inverter being connected to the membrane capacitance (Cm) and the output of said inverter being connected to the input of the second inverter and to the gate of one of the transistors (7; 8) of the bridge, the output of the second inverter being connected to the gate of the other transistor (7; 8) of the bridge, the artificial neuron comprising only six transistors. - a capacitance, called membrane capacitance (Cm), - an input, called external synaptic excitation current (I ex), the membrane capacitance (Cm) integrating this input current, - a negative feedback pulse circuit supplied by a power supply (Vs, Vd) at negative voltage (Vs) lying between -200 mV and 0 mV and at positive voltage (Vd) lying between 0 mV and + 200 mV, consisting of: o a bridge based on PMOS and NMOS transistors in series and connected, at the drains thereof, by a midpoint to the membrane capacitance (Cm), this midpoint defining the output of the artificial neuron (1; 1'), o at least one capacitance, called delay capacitance (Cna, Ck), between the gate and the source of one of the transistors (7, 8) of the bridge, o a bridge based on PMOS and NMOS transistors in series and connected, at the drains thereof, by a midpoint to the membrane capacitance (Cm), this midpoint defining the output of the artificial neuron (1; 1'), o at least one capacitance, called delay capacitance (Cna, Ck), between the gate and the source of one of the transistors (7, 8) of the bridge, - only two CMOS inverters (5, 6) connected in a cascade-like manner, each being composed of two transistors, the input of the first inverter being connected to the membrane capacitance (Cm) and the output of said inverter being connected to the input of the second inverter and to the gate of one of the transistors (7; 8) of the bridge, the output of the second inverter being connected to the gate of the other transistor (7; 8) of the bridge, the artificial neuron comprising only six transistors.
A semiconductor device comprising: a multilayered wiring layer in which insulating layers and diffusion preventing layers are alternately laminated and a wiring layer is provided inside an insulating layer (120, 130, 140, 150); a through-hole that is provided to penetrate through at least one or more insulating layers from one surface of the multilayered wiring layer and has an inside covered with a protective side wall layer; and a gap that is provided in at least one or more insulating layers immediately below the through-hole, wherein at least a part of the wiring layer is provided inside the gap. a multilayered wiring layer in which insulating layers and diffusion preventing layers are alternately laminated and a wiring layer is provided inside an insulating layer (120, 130, 140, 150); a through-hole that is provided to penetrate through at least one or more insulating layers from one surface of the multilayered wiring layer and has an inside covered with a protective side wall layer; and a gap that is provided in at least one or more insulating layers immediately below the through-hole, wherein at least a part of the wiring layer is provided inside the gap.
A housing configured to house an electric machine, the housing being formed as one unitary element made of heat conducting material, wherein the housing is configured to form a first space in which first space a stator and a rotor are to be located, a second space in which second space electronics for operation of the electric machine is to be located and a third space formed in the housing, seen in axial direction of the electric machine between the first space and the second space, the third space having a at least one surface facing the first space and at least one other surface facing the second space, the housing comprising at least one inlet for a liquid to the third space and at least one outlet for the liquid from the third space, wherein the third space forms a cooling arrangement simultaneously cooling both the stator /rotor and the electronics without extending radially outside the electrical machine.
Laundry treatment device, having at least one lint filter, wherein cleaning liquid of a process air lint filter can be captured by the lint filter, characterised in that the lint filter represents a service-life lint repository, which is provided to store the lint deposited inside it over the service life of the laundry treatment device, so that no actions for emptying the lint repository need to be performed, wherein cleaning liquid of a cleanable condensation unit in the form of a heat exchanger can be captured by the lint filter and the lint filter is accommodated below the cleanable condensation unit.
Spacer device for the two-stage treatment of infections of the prosthesis of the human limbs, i.e. for a treatment including a first stage of removing an infected arthroprosthesis and a second stage of a new re-implant of arthroprosthesis upon clearing the tissues of the patient in terms of infection, said spacer being made of biologically compatible material comprising polymethylmethacrylate adapted to be added and/or which can be added with pharmaceutical products, active and/or therapeutic ingredients, comprising a first portion adapted to be fixed to a corresponding bone bed, a second portion adapted to be inserted in a corresponding articular area of the patient, said first portion and said second portion being connected through adjustable joining means, wherein said joining means comprise mutual coupling surfaces (10,11) respectively provided in said first portion and said second portion, wherein said mutual coupling surfaces (10,11) comprise a screw and a nut screw, wherein said screw is provided in said first portion and said nut screw is provided in said second portion or wherein said screw is provided in said second portion and said nut screw is provided in said first portion, characterised in that said mutual coupling surfaces (10,11) are coated with said biologically compatible material which comprises polymethylmethacrylate and in that said screw and nut screw are of the type having a threading with rounded profile.
An epitaxial group-III-nitride buffer-layer structure on a silicon or heterosubstrate, wherein the buffer-layer structure comprises at least one stress management layer sequence including an interlayer structure arranged between and adjacent to a first and a second group-III-nitride layer, wherein the interlayer structure comprises a group-III-nitride interlayer material having a larger band gap than the materials of the first and second group-III-nitride layers, and wherein a p-type-dopant-concentration profile drops, starting from at least 1x10 18 cm -3, by at least a factor of two in transition from the interlayer structure to the first and second group-III-nitride layers, wherein the stress management layer sequence S is followed by an AlGaN back barrier layer with a graded carbon concentration starting with a carbon concentration of 1x10 18 cm -3 at an interface between back barrier layer and third group-ill-nitride layer, and ending with a carbon concentration of less than 4x10 16 cm -3 at an interface between back barrier layer and a following active layer, and the back barrier layer is followed by an active layer and wherein an Fe concentration within the buffer-layer structure is less than 4.10 16 cm -3.
A tetrazolinone compound represented by formula: wherein A represents the following group A1, A2, A3, or A4; in which R 6 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, a C3-C4 cycloalkyl group optionally having one or more halogen atoms, or a C1-C4 alkoxy group optionally having one or more halogen atoms, R 7 and R 8 each represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C1-C4 alkoxy group optionally having one or more halogen atoms, G 1 and G 3 each represents a hydrogen atom, a halogen atom, a C1-C4 alkoxy group optionally having one or more halogen atoms, or a C1-C4 alkyl group optionally having one or more halogen atoms, G 2, J 1, and J 4 each represents a hydrogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C3-C4 cycloalkyl group optionally having one or more halogen atoms, and E 1, E 2, E 3, J 2, and J 3 each represents a hydrogen atom, a halogen atom, a cyano group, an aldehyde group, a C1-C4 alkoxy group optionally having one or more halogen atoms, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C3-C4 cycloalkyl group optionally having one or more halogen atoms. in which R 6 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, a C3-C4 cycloalkyl group optionally having one or more halogen atoms, or a C1-C4 alkoxy group optionally having one or more halogen atoms, R 7 and R 8 each represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C1-C4 alkoxy group optionally having one or more halogen atoms, G 1 and G 3 each represents a hydrogen atom, a halogen atom, a C1-C4 alkoxy group optionally having one or more halogen atoms, or a C1-C4 alkyl group optionally having one or more halogen atoms, G 2, J 1, and J 4 each represents a hydrogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C3-C4 cycloalkyl group optionally having one or more halogen atoms, and E 1, E 2, E 3, J 2, and J 3 each represents a hydrogen atom, a halogen atom, a cyano group, an aldehyde group, a C1-C4 alkoxy group optionally having one or more halogen atoms, a C1-C4 alkyl group optionally having one or more halogen atoms, or a C3-C4 cycloalkyl group optionally having one or more halogen atoms.
A method for straightening a steel pipe or bar, in which hard alloy straightening rolls are used, characterized in that the hardness of each hard alloy straightening roll is HRA85 to 87.
A footwear lacing apparatus comprising: a housing structure including a top section and a bottom section; and a spool including a superior surface, a lace spool under the superior surface and a spool shaft, the spool integrated into the top section of the housing structure; a clutch system; and a drive mechanism coupling with the spool via the clutch system, the drive mechanism adapted to rotate the spool to tighten or loosen a lace cable integrated into the footwear, the drive mechanism comprising a worm drive, a worm gear, a gear motor and a gear box; wherein the worm gear is configured to inhibit back driving of the worm drive and the gear motor; and wherein the clutch system couples the worm gear to the spool. a housing structure including a top section and a bottom section; and a spool including a superior surface, a lace spool under the superior surface and a spool shaft, the spool integrated into the top section of the housing structure; a clutch system; and a drive mechanism coupling with the spool via the clutch system, the drive mechanism adapted to rotate the spool to tighten or loosen a lace cable integrated into the footwear, the drive mechanism comprising a worm drive, a worm gear, a gear motor and a gear box; wherein the worm gear is configured to inhibit back driving of the worm drive and the gear motor; and wherein the clutch system couples the worm gear to the spool. wherein the worm gear is configured to inhibit back driving of the worm drive and the gear motor; and wherein the clutch system couples the worm gear to the spool.
A method of detecting an allergic disorder in a subject, comprising: (a) detecting a frequency of CD4+ T cells in a biological sample of said subject; (b) detecting a frequency of CD4+ CD161+ CRTH2+ Th2a cells in the biological sample; and (c) comparing the frequency of the CD4+ CD161+ CRTH2+ Th2a subset with the frequency of the CD4+ T cells, wherein a higher frequency of the CD4+ CD161 + CRTH2+ Th2a subset as compared to a CD4+ CD161+ CRTH2+ Th2a frequency in a control subject indicates said allergic disorder. (a) detecting a frequency of CD4+ T cells in a biological sample of said subject; (b) detecting a frequency of CD4+ CD161+ CRTH2+ Th2a cells in the biological sample; and (c) comparing the frequency of the CD4+ CD161+ CRTH2+ Th2a subset with the frequency of the CD4+ T cells, wherein a higher frequency of the CD4+ CD161 + CRTH2+ Th2a subset as compared to a CD4+ CD161+ CRTH2+ Th2a frequency in a control subject indicates said allergic disorder.
An element for ventilating a housing containing an electrical, mechanical, electromechanical or similar member, such as an automobile headlamp or a housing for electrical members or components, said element comprising a rigid body having an outer cylindrical wall, closed at a first end by a closure part, said cylindrical wall being open at a second end couplable to said housing, said body containing an internal member of at least partly yieldable material having a first end close to the closure part of the rigid body and carrying a filtering membrane, and an open second end facing, in use, said housing, characterised in that from said closure part an internal cylindrical portion projects containing said member and couples to this latter by interference so as to retain it within the body.
A method performed by a wireless device for decoding public land mobile network, PLMN, information, the method comprising: receiving a message comprising PLMN information for a plurality of cells; determining PLMN information from the message for a first group of cells, the first group of cells comprising at least one cell wherein each cell of the first group of cells is associated with a first core network type; and determining PLMN information from the message for a second group of cells, the second group of cells comprising at least one cell wherein each cell of the second group of cells is associated with a second core network type, and wherein at least one cell is a part of the first group of cells and the second group of cells, and wherein the PLMN information for the at least one cell in the first group of cells and the second group of cells is provided only once, and wherein determining PLMN information for the at least one cell that is a part of the first group of cells and the second group of cells comprises applying an index set to the cells of the first group of cells, wherein each index of the index set corresponds to a cell in the first group of cells, wherein the index set identifies each cell of the first group of cells that is also in the second group of cells, and wherein the PLMN information for the at least one cell with respect to the second core network type is based on the PLMN information for the corresponding cell with respect to the first core network type. receiving a message comprising PLMN information for a plurality of cells; determining PLMN information from the message for a first group of cells, the first group of cells comprising at least one cell wherein each cell of the first group of cells is associated with a first core network type; and determining PLMN information from the message for a second group of cells, the second group of cells comprising at least one cell wherein each cell of the second group of cells is associated with a second core network type, and wherein at least one cell is a part of the first group of cells and the second group of cells, and wherein the PLMN information for the at least one cell in the first group of cells and the second group of cells is provided only once, and wherein determining PLMN information for the at least one cell that is a part of the first group of cells and the second group of cells comprises applying an index set to the cells of the first group of cells, wherein each index of the index set corresponds to a cell in the first group of cells, wherein the index set identifies each cell of the first group of cells that is also in the second group of cells, and wherein the PLMN information for the at least one cell with respect to the second core network type is based on the PLMN information for the corresponding cell with respect to the first core network type.