mhurhangee/ep-ind-claims huggingface dataset:
Blade cascade for a turbomachine, in particular a gas turbine, the blade cascade comprising a plurality of identical blade groups which are arranged next to one another in the circumferential direction and each comprise a first individual blade having an airfoil with a blade profile and a first lateral wall, and an adjacent second individual blade which is different from the first individual blade, having an airfoil with a blade profile and a second lateral wall, a lateral wall being an inner surface of a blade platform that faces the working fluid flow channel or a radially outer surface of a blade shroud that faces the working fluid flow channel, characterized in that the first and the second lateral wall (11, 21) have different contourings, contouring being understood to mean the course of a radial extension along a circumferential direction coordinate at at least one axial position and/or along an axial coordinate at at least one circumferential position, the circumferential direction coordinate in each case starting at a circumferential end face of a blade group, and different contourings being understood to mean different courses of the radial extension, the contour of the second lateral wall at at least one circumferential position in the radial direction deviating by at least 1% of a blade height of the blade cascade and/or by at least 0.1 mm from the contour of the first lateral wall at a position which is offset in the circumferential direction by one blade pitch. a first individual blade having an airfoil with a blade profile and a first lateral wall, and an airfoil with a blade profile and a first lateral wall, and an adjacent second individual blade which is different from the first individual blade, having an airfoil with a blade profile and a second lateral wall, an airfoil with a blade profile and a second lateral wall, a lateral wall being an inner surface of a blade platform that faces the working fluid flow channel or a radially outer surface of a blade shroud that faces the working fluid flow channel, characterized in that the first and the second lateral wall (11, 21) have different contourings, contouring being understood to mean the course of a radial extension along a circumferential direction coordinate at at least one axial position and/or along an axial coordinate at at least one circumferential position, the circumferential direction coordinate in each case starting at a circumferential end face of a blade group, and different contourings being understood to mean different courses of the radial extension, the contour of the second lateral wall at at least one circumferential position in the radial direction deviating by at least 1% of a blade height of the blade cascade and/or by at least 0.1 mm from the contour of the first lateral wall at a position which is offset in the circumferential direction by one blade pitch.
A method for determining an energy-efficient path of an autonomous device wherein said autonomous device moves over a global grid of cells into which a given operating area has been split, wherein the determination of said energy-efficient path comprises the steps of: • processing of the current cell; • taking a measurement σ of the processing; • classifying the measurement σ to be of a particular level Σ, taking into account a predefined division, of the measurements results range, into a plurality of measurements levels; • storing said classified measurement in a memory of the autonomous device and associating it with the current cell; the method being characterized in that determination of said energy-efficient path further comprises the steps of: • selecting a reference probability grid wherein values in the cells of the reference grid express a probability that the measurement of the processing will be the same in its respective cell as it is in the current cell, which represents the current position of the autonomous device, whereas a centre cell, associated with the current cell, is assigned a maximum probability while other cells within the reference grid have a probability assigned, which lowers with an increase of a distance of a cell from the current cell; • updating the probabilities by applying the reference grid to the global grid at its current position such that every cell on the reference grid corresponds unambiguously to one cell on the global grid; and • moving the autonomous device to a next cell of the global grid and setting said next cell as the current cell in order to process the next cell. • processing of the current cell; • taking a measurement σ of the processing; • classifying the measurement σ to be of a particular level Σ, taking into account a predefined division, of the measurements results range, into a plurality of measurements levels; • storing said classified measurement in a memory of the autonomous device and associating it with the current cell; • selecting a reference probability grid wherein values in the cells of the reference grid express a probability that the measurement of the processing will be the same in its respective cell as it is in the current cell, which represents the current position of the autonomous device, whereas a centre cell, associated with the current cell, is assigned a maximum probability while other cells within the reference grid have a probability assigned, which lowers with an increase of a distance of a cell from the current cell; • updating the probabilities by applying the reference grid to the global grid at its current position such that every cell on the reference grid corresponds unambiguously to one cell on the global grid; and • moving the autonomous device to a next cell of the global grid and setting said next cell as the current cell in order to process the next cell.
A polynucleotide comprising an expressible nucleic acid sequence encoding a relaxin family peptide receptor 1 (RXFP1) polypeptide for use in treatment and/or prevention of heart failure in a subject, wherein said use further comprises administration of an RXFP1 agonist.
An article of footwear comprising a knitted component forming an upper of the article of footwear and having a support structure for the article of footwear, the support structure comprising an arch support (109, 309), the arch support comprising: a) a first section formed from a fusible yarn and being disposed adjacent to an external surface of the article of footwear; b) a second section formed from a bulking yarn and disposed adjacent to the first section; and c) a third section formed from a nonfusible yarn and being disposed adjacent to an internal surface of the article of footwear; wherein the fusible yarn is relatively rigid, as compared to the nonfusible yarn, and wherein the second section is disposed between the first section and the third section, the article of footwear being characterized in that the arch support (109, 309) is divided into compartments. a) a first section formed from a fusible yarn and being disposed adjacent to an external surface of the article of footwear; b) a second section formed from a bulking yarn and disposed adjacent to the first section; and c) a third section formed from a nonfusible yarn and being disposed adjacent to an internal surface of the article of footwear; wherein the fusible yarn is relatively rigid, as compared to the nonfusible yarn, and wherein the second section is disposed between the first section and the third section, the article of footwear being characterized in that the arch support (109, 309) is divided into compartments. wherein the fusible yarn is relatively rigid, as compared to the nonfusible yarn, and wherein the second section is disposed between the first section and the third section, the article of footwear being characterized in that the arch support (109, 309) is divided into compartments.
An animal house comprising: a. a base; b. a cover affording a roof and side walls for the house and engaging with the base; c. releasable fastening means arranged to secure the cover to the base such that, when released, the cover may be removed to afford access to the base from above; and d. an end wall of the house that engages said base: characterised in that said end wall has at least two interchangeable configurations by way of interchanging the end wall with another end wall or interchanging a closure means (10,12) of the end wall, the animal house including the interchangeable end walls or interchangeable closure means (10,12) of the end wall. a. a base; b. a cover affording a roof and side walls for the house and engaging with the base; c. releasable fastening means arranged to secure the cover to the base such that, when released, the cover may be removed to afford access to the base from above; and d. an end wall of the house that engages said base: characterised in that said end wall has at least two interchangeable configurations by way of interchanging the end wall with another end wall or interchanging a closure means (10,12) of the end wall, the animal house including the interchangeable end walls or interchangeable closure means (10,12) of the end wall. characterised in that said end wall has at least two interchangeable configurations by way of interchanging the end wall with another end wall or interchanging a closure means (10,12) of the end wall, the animal house including the interchangeable end walls or interchangeable closure means (10,12) of the end wall.
A catheter comprising: an elongated tubular portion having a proximal end and a distal end; a plurality of braided wires extending between said proximal end and said distal end; a hypotube located at said distal end of said elongated tubular portion; said hypotube having a proximal end comprising a plurality of electrical paths connected to notched areas or cut-out areas welded or otherwise electro-mechanically joined to a distal end of said plurality of braided wires so as to create a snug connection with said hypotube; one or more electrically powered components (26A-26D) connected to said hypotube and in electrical communication with one or more of said electrical paths; and, an interface connectable to said proximal end of said elongated tubular portion to supply power to said hypotube via at least two of said plurality of braided wires. an elongated tubular portion having a proximal end and a distal end; a plurality of braided wires extending between said proximal end and said distal end; a hypotube located at said distal end of said elongated tubular portion; said hypotube having a proximal end comprising a plurality of electrical paths connected to notched areas or cut-out areas welded or otherwise electro-mechanically joined to a distal end of said plurality of braided wires so as to create a snug connection with said hypotube; one or more electrically powered components (26A-26D) connected to said hypotube and in electrical communication with one or more of said electrical paths; and, an interface connectable to said proximal end of said elongated tubular portion to supply power to said hypotube via at least two of said plurality of braided wires.
A converter network bridge controller (100, 200, 300, 400) for a power converter hardware being connectable to an alternating current electricity network, comprising: a three-phase alternating current to d-q converter which receives a measured current and provides a d-axis current component and a q-axis current component; a filter being configured for receiving the q-axis current component and for providing in response hereto a filtered q-axis current component as a converter active current component; an output unit configured for generating a quadrature voltage component reference to a PWM modulator which determines the switching of the power converter hardware, wherein the quadrature voltage component reference comprises a first signal and a second signal; the output unit comprising a first part and a second part; the first part being configured for generating the first signal based on a current reference for an active current to be generated by the power converter hardware; and the second part being configured for providing the second signal to reduce a difference between an converter active current component of measured feedback current and the current reference for active current; the second part further comprising: a summing junction for subtracting the converter active current component and the current reference for an active current, and providing a resulting signal; a proportional integral controller configured for receiving the resulting signal and providing the second signal. a three-phase alternating current to d-q converter which receives a measured current and provides a d-axis current component and a q-axis current component; a filter being configured for receiving the q-axis current component and for providing in response hereto a filtered q-axis current component as a converter active current component; an output unit configured for generating a quadrature voltage component reference to a PWM modulator which determines the switching of the power converter hardware, wherein the quadrature voltage component reference comprises a first signal and a second signal; the output unit comprising a first part and a second part; the first part being configured for generating the first signal based on a current reference for an active current to be generated by the power converter hardware; and the second part being configured for providing the second signal to reduce a difference between an converter active current component of measured feedback current and the current reference for active current; the second part further comprising: a summing junction for subtracting the converter active current component and the current reference for an active current, and providing a resulting signal; a proportional integral controller configured for receiving the resulting signal and providing the second signal. a summing junction for subtracting the converter active current component and the current reference for an active current, and providing a resulting signal; a proportional integral controller configured for receiving the resulting signal and providing the second signal.
A press-coated tablet formulation for an immediate, followed by a delayed release of an active agent, the tablet comprising (a) a core comprising an active agent together with an excipient(s); and (b) a delayed release layer surrounding the core and comprising a wax and micronised low substituted hydroxypropyl cellulose (L-HPC), with a mean diameter of 20μm, which is insoluble in water and comprises a glucose backbone substituted by hydroxypropyl groups and has a molecular weight of around 115,000 and a hydroxypropyl cellulose content of around 8% in a ratio of 40:60 to 60:40 w/w; wherein the delayed release layer substantially delays release of the active agent within the core for between 3 - 8 hours after administration of the tablet by a subject and thereafter a pulsed release of the active agent from the core occurs, such that at least 70% of the active agent in the core is released within 5-45 mins; and (c) a top-coating layer comprising a portion of an active agent together with a sugar and L-HPC, wherein at least 70-90% of the active agent is released within 5-45 mins following administration to the subject of the tablet. (a) a core comprising an active agent together with an excipient(s); and (b) a delayed release layer surrounding the core and comprising a wax and micronised low substituted hydroxypropyl cellulose (L-HPC), with a mean diameter of 20μm, which is insoluble in water and comprises a glucose backbone substituted by hydroxypropyl groups and has a molecular weight of around 115,000 and a hydroxypropyl cellulose content of around 8% in a ratio of 40:60 to 60:40 w/w; wherein the delayed release layer substantially delays release of the active agent within the core for between 3 - 8 hours after administration of the tablet by a subject and thereafter a pulsed release of the active agent from the core occurs, such that at least 70% of the active agent in the core is released within 5-45 mins; and (c) a top-coating layer comprising a portion of an active agent together with a sugar and L-HPC, wherein at least 70-90% of the active agent is released within 5-45 mins following administration to the subject of the tablet.
Adjustable camshaft for the valve drive of an internal combustion engine, having an outer shaft and having an inner shaft which extends through the outer shaft, wherein, on the outer shaft, there is arranged at least one cam element and the latter is connected rotationally conjointly to the inner shaft, and wherein the cam element has a shaft passage with an internal bearing surface, which, together with a bearing surface on the outer side of the outer shaft, forms a plain bearing arrangement for the rotatable arrangement of the cam element on the outer shaft, characterized in that at least one of the bearing surfaces (13, 14) is formed, at least in sections, with a spherical shape wherein the at least one bearing surface (13, 14) has at least one cylindrical section which is formed adjacent to the spherical shape.
A method of forming a dynamic library of compounds which are potentially capable of binding to a target, which method comprises i) selecting one first set of molecules which molecules each carry at least one first functional group which is capable of interacting with at least one other functional group under the formation of a reversible bond; ii) selecting at least one further set of molecules which molecules carry at least one second functional group which is capable of interacting with the first functional group on the first set of molecules; iii) reacting the two sets of molecules with each other and in the presence of the target, under conditions where a formation of reversible bonds between the functional groups on the molecules forming each of the sets occurs; wherein a library containing products, that can be isolated and do not decompose when the set of molecules present in excess is removed, is generated, the formation of the library is carried out in an aqueous medium at a pH of from 5 to 9 and is fully reversible throughout the entire formation of the library, the formation of reversible bonds is the formation of hydrazones R 1 C(R 2)=N-N(R 3)-D by the reaction between a carbonyl function R 1 C R 2 and a hydrazine function according to the general formula H 2 N-N(R 3)-D wherein R 1 and R 2 are independently of each other hydrogen or an organic radical, R 3 is hydrogen, an organic radical or an electron withdrawing group, and D is selected from the group -C -, -C -O-, -C -S-, -C -N<, -C -C -, - C - -O-, -C -C -N<, -C -, -C -S-, -C -N<, -C(=N)-N<, -C(=N-CN)-N<, -C(=N-NO 2)-N<, -S -, -S 2 -, -S 2 -O-, -S 2 -N<, -P (-O-)(-O-), -P (-O-)-, -P -, or D forms together with the group R 3 and the nitrogen atom to which it is attached a heterocycle, and the respective amounts of each set of molecules employed are such that one functional group of that at least one second functional groups is present in an at least 5-fold excess with respect to the other functional group during the formation of the library, which means that an excess of hydrazine groups is used relative to carbonyl groups. i) selecting one first set of molecules which molecules each carry at least one first functional group which is capable of interacting with at least one other functional group under the formation of a reversible bond; ii) selecting at least one further set of molecules which molecules carry at least one second functional group which is capable of interacting with the first functional group on the first set of molecules; iii) reacting the two sets of molecules with each other and in the presence of the target, under conditions where a formation of reversible bonds between the functional groups on the molecules forming each of the sets occurs;
Copolymers AB comprising moieties derived from - vinyl-terminated polysiloxanes A with more than one vinyl group bound to the polysiloxane, and - moieties derived from two or more alkyl esters B of an olefinically unsaturated carboxylic acid, wherein at least two different alkyl esters are used, the first being referred to as alkyl ester B1, and the second being referred to as alkyl ester B2; wherein the alkyl group of the first alkyl ester B1 of an olefinically unsaturated carboxylic acid has from one to five carbon atoms, and wherein the alkyl group of the second alkyl ester B2 of an olefinically unsaturated carboxylic acid has from six to thirty carbon atoms, and - moieties derived from at least one hydroxyalkyl ester B3 of an olefinically unsaturated carboxylic acid, the ester B3 having at least one hydroxyl group in the alkyl group, and from two to six carbon atoms in the alkyl group, wherein in the copolymers AB, the mass fractions w of repeating units derived from the monomers, determined as disclosed in the description, are as follows: for divinyl-terminated polysiloxanes A, w is from 0.5 % to 4.5 %; for alkyl esters B1, w is from 30 % to 85 %; for alkyl esters B2, w is from 5 % to 55 %; for hydroxyalkyl esters B3, w is from 5 % to 20 %. - vinyl-terminated polysiloxanes A with more than one vinyl group bound to the polysiloxane, and - moieties derived from two or more alkyl esters B of an olefinically unsaturated carboxylic acid, wherein at least two different alkyl esters are used, the first being referred to as alkyl ester B1, and the second being referred to as alkyl ester B2; wherein the alkyl group of the first alkyl ester B1 of an olefinically unsaturated carboxylic acid has from one to five carbon atoms, and wherein the alkyl group of the second alkyl ester B2 of an olefinically unsaturated carboxylic acid has from six to thirty carbon atoms, and - moieties derived from at least one hydroxyalkyl ester B3 of an olefinically unsaturated carboxylic acid, the ester B3 having at least one hydroxyl group in the alkyl group, and from two to six carbon atoms in the alkyl group, for divinyl-terminated polysiloxanes A, w is from 0.5 % to 4.5 %; for alkyl esters B1, w is from 30 % to 85 %; for alkyl esters B2, w is from 5 % to 55 %; for hydroxyalkyl esters B3, w is from 5 % to 20 %.