A method for making lubricant base stock, comprising: performing solvent deasphalting using a C 5+ solvent under first solvent deasphalting conditions on a feedstock having a T5 boiling point of at least 400°C to produce a first deasphalted oil and a first deasphalter residue, the effective solvent deasphalting conditions producing a yield of first deasphalted oil of at least 70 wt% of the feedstock; performing solvent deasphalting on at least a portion of the first deasphalted oil under second solvent deasphalting conditions using a C 3 solvent, a C 4 solvent, or a combination thereof to form a second deasphalted oil and a second deasphalter resin; hydroprocessing at least a portion of the second deasphalted oil under first effective hydroprocessing conditions to form a hydroprocessed effluent, the at least a portion of the second deasphalted oil having an aromatics content of at least 50 wt%, the hydroprocessed effluent having a sulfur content of 300 wppm or less, and a nitrogen content of 100 wppm or less; separating the hydroprocessed effluent to form at least a fraction comprising a fuels boiling range fraction and a bottoms fraction; hydroprocessing at least a portion of the hydroprocessed bottoms fraction under second effective hydroprocessing conditions, the second effective hydroprocessing conditions comprising catalytic dewaxing conditions, to form a catalytically dewaxed effluent; and hydrotreating at least a portion of the second deasphalter resin under hydrotreating conditions to form a hydrotreated resin effluent having a sulfur content of 500 wppm to 10,000 wppm; wherein the method additionally comprises: performing a boiling point separation on at least a portion of the hydrotreated resin effluent to form a 566°C- hydrotreated resin fraction and a bottoms resin fraction, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the 566°C- hydrotreated resin fraction; or performing solvent deasphalting on at least a portion of the hydrotreated resin effluent under third solvent deasphalting conditions using a C 3 solvent, a C 4 solvent, or a combination thereof to form a third deasphalted oil and third deasphalter residue, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the third deasphalted oil. performing solvent deasphalting using a C 5+ solvent under first solvent deasphalting conditions on a feedstock having a T5 boiling point of at least 400°C to produce a first deasphalted oil and a first deasphalter residue, the effective solvent deasphalting conditions producing a yield of first deasphalted oil of at least 70 wt% of the feedstock; performing solvent deasphalting on at least a portion of the first deasphalted oil under second solvent deasphalting conditions using a C 3 solvent, a C 4 solvent, or a combination thereof to form a second deasphalted oil and a second deasphalter resin; hydroprocessing at least a portion of the second deasphalted oil under first effective hydroprocessing conditions to form a hydroprocessed effluent, the at least a portion of the second deasphalted oil having an aromatics content of at least 50 wt%, the hydroprocessed effluent having a sulfur content of 300 wppm or less, and a nitrogen content of 100 wppm or less; separating the hydroprocessed effluent to form at least a fraction comprising a fuels boiling range fraction and a bottoms fraction; hydroprocessing at least a portion of the hydroprocessed bottoms fraction under second effective hydroprocessing conditions, the second effective hydroprocessing conditions comprising catalytic dewaxing conditions, to form a catalytically dewaxed effluent; and hydrotreating at least a portion of the second deasphalter resin under hydrotreating conditions to form a hydrotreated resin effluent having a sulfur content of 500 wppm to 10,000 wppm; wherein the method additionally comprises: performing a boiling point separation on at least a portion of the hydrotreated resin effluent to form a 566°C- hydrotreated resin fraction and a bottoms resin fraction, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the 566°C- hydrotreated resin fraction; or performing solvent deasphalting on at least a portion of the hydrotreated resin effluent under third solvent deasphalting conditions using a C 3 solvent, a C 4 solvent, or a combination thereof to form a third deasphalted oil and third deasphalter residue, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the third deasphalted oil. performing a boiling point separation on at least a portion of the hydrotreated resin effluent to form a 566°C- hydrotreated resin fraction and a bottoms resin fraction, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the 566°C- hydrotreated resin fraction; or performing solvent deasphalting on at least a portion of the hydrotreated resin effluent under third solvent deasphalting conditions using a C 3 solvent, a C 4 solvent, or a combination thereof to form a third deasphalted oil and third deasphalter residue, wherein hydroprocessing at least a portion of the second deasphalted oil further comprises hydroprocessing at least a portion of the third deasphalted oil.