A system configured to deliver a pressurized flow of breathable gas to the airway of a subject, the system comprising: a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject; one or more sensors configured to generate output signals conveying information related to respiratory effort by the subject; one or more processors configured to execute computer program modules, the computer program modules comprising: a control module configured to control the pressure generator in accordance with a therapy regimen such that the breaths occur at a respiratory rate; a inspiration pressure module configured to determine an inspiratory pressure level; a rate determination module configured to determine a therapeutic respiratory rate; and an expiration pressure module configured to determine an expiratory pressure level, wherein the control module is configured to control the pressure generator such that respiration by the subject is maintained at the therapeutic respiratory rate, and such that during inspirations the pressurized flow of breathable gas is delivered at the inspiratory pressure level determined by the inspiration pressure module, and during expirations the pressurized flow of breathable gas is delivered at the expiratory pressure level, characterized in that the system further comprise a volume determination module configured to determine an average tidal volume of breaths during the delivery of the pressurized flow of breathable gas to the subject over a number of breaths or over a sliding window of time based on the output signals of the one or more sensors, in that the inspiration pressure module determines the inspiratory pressure level that will maintain a target average tidal volume, and in that control module is configured to control the pressure generator such that the target average tidal volume is maintained during breaths for the subject. a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject; one or more sensors configured to generate output signals conveying information related to respiratory effort by the subject; one or more processors configured to execute computer program modules, the computer program modules comprising: a control module configured to control the pressure generator in accordance with a therapy regimen such that the breaths occur at a respiratory rate; a inspiration pressure module configured to determine an inspiratory pressure level; a rate determination module configured to determine a therapeutic respiratory rate; and an expiration pressure module configured to determine an expiratory pressure level, wherein the control module is configured to control the pressure generator such that respiration by the subject is maintained at the therapeutic respiratory rate, and such that during inspirations the pressurized flow of breathable gas is delivered at the inspiratory pressure level determined by the inspiration pressure module, and during expirations the pressurized flow of breathable gas is delivered at the expiratory pressure level, a control module configured to control the pressure generator in accordance with a therapy regimen such that the breaths occur at a respiratory rate; a inspiration pressure module configured to determine an inspiratory pressure level; a rate determination module configured to determine a therapeutic respiratory rate; and an expiration pressure module configured to determine an expiratory pressure level, wherein the control module is configured to control the pressure generator such that respiration by the subject is maintained at the therapeutic respiratory rate, and such that during inspirations the pressurized flow of breathable gas is delivered at the inspiratory pressure level determined by the inspiration pressure module, and during expirations the pressurized flow of breathable gas is delivered at the expiratory pressure level, characterized in that the system further comprise a volume determination module configured to determine an average tidal volume of breaths during the delivery of the pressurized flow of breathable gas to the subject over a number of breaths or over a sliding window of time based on the output signals of the one or more sensors, in that the inspiration pressure module determines the inspiratory pressure level that will maintain a target average tidal volume, and in that control module is configured to control the pressure generator such that the target average tidal volume is maintained during breaths for the subject.