A compound of Formula II: or a stereoisomer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein each of A 1 and A 2, independently, is N or CR 9, provided that at least one of A 1 and A 2 is N; each of B 1, B 2, B 3 and B 4, independently, is N or CR 5, provided that no more than two of B 1, B 2, B 3 and B 4 is N; C 1 is CR 10. D 1 is N or CR 11; D 2 is N or CR 12; L 1 is NR 3, O, S or CR 3 R 3; L 2 is NR 3, O or S; R 1 is OR 14, SR 14, OR 15, SR 15, NR 14 R 15, NR 15 R 15, (CHR 15) n R 14, (CHR 15) n R 15 or R 15; alternatively R 1 and R 11 taken together with the carbon atoms to which they are attached form a partially or fully unsaturated 5- or 6-membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N and S, and the ring optionally substituted independently with 1-3 substituents of oxo, R 15, SR 14, OR 14, SR 15, OR 15, OC R 15, COOR 15, C R 15, C NR 15 R 15, NR 4 R 5 or NR 15 R 5; R 2 is H, halo, NO 2, CN, C 1-10 alkyl or C 1-10 alkoxyl; each of R 3, R 4 and R 9, independently, is H; each R 5 is, independently, is SR 14, OR 14, SR 15, OR 15, NR 14 R 15, NR 15 R 15, C R 14, C R 15, COOR 15, OC R 15, C C R 15, C NR 14 R 15, C NR 15 R 15, NR 15 C R 14, NR 15 C R 15, NR 15 C NR 14 R 15, NR 15 C NR 15 R 15, NR 15 C C R 15, NR 15 (COOR 15), OC NR 15 R 15, S 2 R 14, S 2 R 15, S 2 NR 14 R 15, S 2 NR 15 R 15, NR 15 S 2 NR 15 R 15, NR 15 S 2 R 14, NR 15 S 2 R 15, NR 15 S 2 NR 14 R 15, NR 15 C C NR 14 R 15, NR 15 C C NR 15 R 15 or R 15; R 6 is R 14; each of R 7 and R 8, independently, is R 13, R 14 or R 15; alternatively, either of R 7 and R 8 taken together with the carbon atoms to which they are attached form a fully saturated or partially or fully unsaturated 5- or 6-membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and the ring optionally substituted independently with 1-4 substituents of R 13, R 14 or R 15; each of R 10, R 11 and R 12, independently, is SR 14, OR 14, SR 15, OR 15, NR 14 R 15, NR 15 R 15, C R 14, C R 15 or R 15; R 13 is SR 14, OR 14, SR 15, OR 15, NR 14 R 15, NR 15 R 15, C R 14, C R 15, OC R 14, OC R 15, COOR 14, COOR 15, C NR 14 R 15, C NR 15 R 15, NR 15 C R 14, NR 15 C R 15, C C R 15, NR 15 C NR 14 R 15, NR 15 C NR 15 R 15, NR 15 C C R 15, NR 15 (COOR 14), NR 15 (COOR 15), NR 15 C C NR 14 R 15, NR 15 C C NR 15 R 15, S 2 R 14, S 2 R 15, S 2 NR 14 R 15, S 2 NR 15 R 15 NR 15 S 2 R 14, NR 15 S 2 R 15, NR 15 S 2 NR 14 R 15 or NR 15 S 2 NR 15 R 15; R 14 is a partially or fully saturated or fully unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, the ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, the heteroatoms selected from O, N, or S, wherein 0, 1, 2 or 3 atoms of each ring is optionally substituted independently with 1-5 substituents of R 15; R 15 is H, halo, haloalkyl, haloalkoxyl, oxo, CN, OH, SH, NO 2. NH 2, acetyl, C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl or a saturated or partially or fully unsaturated 5-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein each of the C 1-10 -alkyl, C 2-10 -alkenyl, C 2-10 -alkynyl, C 3-10 -cycloalkyl, C 4-10 -cycloalkenyl, C 1-10 -alkylamino-, C 1-10 -dialkylamino-, C 1-10 -alkoxyl, C 1-10 -thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO 2, NH 2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, methylamine, dimethylamine, ethylamine, diethylamine, propylamine, isopropylamine, dipropylamine, diisopropylamine, benzyl or phenyl; and n is 0, 1, 2, 3 or 4; provided that no more than one of D 1 and D 2 is N.