A bifunctional compound of Formula X: wherein: the Targeting Ligand is of Formula TL-I: wherein: X 1 is NR 5 or O; each R 1 and each R 4 are independently (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 1 -C 4) alkoxy, (C 1 -C 4) haloalkoxy, halogen, OH, or NH 2; R 2 and R 3 are each independently H, (C 1 -C 4) alkyl, or (C 1 -C 4) haloalkyl; R 5 is H, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, or C (C 1 -C 4) alkyl; n1 is 0, 1, 2 or 3; and n2 is 0, 1, or 2; wherein the Targeting Ligand is bonded to the Linker via the next to in TL-I; wherein the Linker is of Formula L1: or a stereoisomer thereof, wherein p1 is an integer selected from 0 to 12; p2 is an integer selected from 0 to 12; p3 is an integer selected from 1 to 6; each W is independently absent, CH 2, O, S, or NR 34; Z 1 is C NR 34; each R 34 is independently H or C 1 -C 3 alkyl; and Q 1 is absent, C, NHC (CH 2) 0-1, OCH 2 C, O(CH 2) 1-2, or wherein the Linker is covalently bonded to a Degron via the next to Q 1, and covalently bonded to a Targeting Ligand via the next to Z 1; and the Degron is of Formula D1: wherein: Y is a bond, (CH 2) 1-6, (CH 2) 0-6 -O, (CH 2) 0-6 -C NR 35, (CH 2) 0-6 -NR 35 C, (CH 2) 0-6 -NH, or (CH 2) 0-6 -NR 36, or preferably Y is a bond, O, or NH; Z 3 is C or C(R 37) 2, or preferably Z 3 is C or CH 2; R 35 is H or C 1 -C 6 alkyl; R 36 is C 1 -C 6 alkyl or C -C 1 -C 6 alkyl; each R 37 is independently H or C 1 -C 3 alkyl; each R 38 is independently C 1 -C 3 alkyl; R 39 is H, deuterium, C 1 -C 3 alkyl, F, or Cl; each R 40 is independently halogen, OH, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; q is 0, 1, or 2; v is 0, 1, 2, or 3; wherein the Degron is covalently bonded to the Linker via or a stereoisomer or pharmaceutically acceptable salt thereof. the Targeting Ligand is of Formula TL-I: wherein: X 1 is NR 5 or O; each R 1 and each R 4 are independently (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 1 -C 4) alkoxy, (C 1 -C 4) haloalkoxy, halogen, OH, or NH 2; R 2 and R 3 are each independently H, (C 1 -C 4) alkyl, or (C 1 -C 4) haloalkyl; R 5 is H, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, or C (C 1 -C 4) alkyl; n1 is 0, 1, 2 or 3; and n2 is 0, 1, or 2; X 1 is NR 5 or O; each R 1 and each R 4 are independently (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 1 -C 4) alkoxy, (C 1 -C 4) haloalkoxy, halogen, OH, or NH 2; R 2 and R 3 are each independently H, (C 1 -C 4) alkyl, or (C 1 -C 4) haloalkyl; R 5 is H, (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, or C (C 1 -C 4) alkyl; n1 is 0, 1, 2 or 3; and n2 is 0, 1, or 2; wherein the Targeting Ligand is bonded to the Linker via the next to in TL-I; wherein the Linker is of Formula L1: or a stereoisomer thereof, wherein p1 is an integer selected from 0 to 12; p2 is an integer selected from 0 to 12; p3 is an integer selected from 1 to 6; each W is independently absent, CH 2, O, S, or NR 34; Z 1 is C NR 34; each R 34 is independently H or C 1 -C 3 alkyl; and Q 1 is absent, C, NHC (CH 2) 0-1, OCH 2 C, O(CH 2) 1-2, or p1 is an integer selected from 0 to 12; p2 is an integer selected from 0 to 12; p3 is an integer selected from 1 to 6; each W is independently absent, CH 2, O, S, or NR 34; Z 1 is C NR 34; each R 34 is independently H or C 1 -C 3 alkyl; and Q 1 is absent, C, NHC (CH 2) 0-1, OCH 2 C, O(CH 2) 1-2, or wherein the Linker is covalently bonded to a Degron via the next to Q 1, and covalently bonded to a Targeting Ligand via the next to Z 1; and the Degron is of Formula D1: wherein: Y is a bond, (CH 2) 1-6, (CH 2) 0-6 -O, (CH 2) 0-6 -C NR 35, (CH 2) 0-6 -NR 35 C, (CH 2) 0-6 -NH, or (CH 2) 0-6 -NR 36, or preferably Y is a bond, O, or NH; Z 3 is C or C(R 37) 2, or preferably Z 3 is C or CH 2; R 35 is H or C 1 -C 6 alkyl; R 36 is C 1 -C 6 alkyl or C -C 1 -C 6 alkyl; each R 37 is independently H or C 1 -C 3 alkyl; each R 38 is independently C 1 -C 3 alkyl; R 39 is H, deuterium, C 1 -C 3 alkyl, F, or Cl; each R 40 is independently halogen, OH, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; q is 0, 1, or 2; v is 0, 1, 2, or 3; Y is a bond, (CH 2) 1-6, (CH 2) 0-6 -O, (CH 2) 0-6 -C NR 35, (CH 2) 0-6 -NR 35 C, (CH 2) 0-6 -NH, or (CH 2) 0-6 -NR 36, or preferably Y is a bond, O, or NH; Z 3 is C or C(R 37) 2, or preferably Z 3 is C or CH 2; R 35 is H or C 1 -C 6 alkyl; R 36 is C 1 -C 6 alkyl or C -C 1 -C 6 alkyl; each R 37 is independently H or C 1 -C 3 alkyl; each R 38 is independently C 1 -C 3 alkyl; R 39 is H, deuterium, C 1 -C 3 alkyl, F, or Cl; each R 40 is independently halogen, OH, C 1 -C 6 alkyl, or C 1 -C 6 alkoxy; q is 0, 1, or 2; v is 0, 1, 2, or 3; wherein the Degron is covalently bonded to the Linker via or a stereoisomer or pharmaceutically acceptable salt thereof.