A compound of formula, or a tautomer, mesomer, raceme, enantiomer, diastereomer, and mixture thereof, and a pharmaceutically acceptable salt thereof: wherein: A is CH or N; L is a bond or C 1-12 alkyl; R 1 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 15, -OC R 15, -C R 15, -C NR 16 R 17, -NHC R 15, -NR 16 R 17, -OC NR 16 R 17, -NHC NR 16 R 17 and -S m R 15, wherein the C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of halogen, hydroxy, cyano, nitro, C 1-12 alkyl, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 15, -OC R 15 and -C R 15,; R 2 is C 1-12 alkyl; R 4 is hydrogen; R is selected from the group consisting of hydrogen and halogen; R 3 is selected from the group consisting of hydrogen, halogen and C 1-12 alkyl; R 5 or R 6 is each independently hydrogen; either R 7 or R 8 is each independently hydrogen; R 9 or R 10 is hydrogen; either R 11, R 12, R 13 or R 14 is each hydrogen; or, R 11 and R 12 or R 13 and R 14 are taken together to form an oxo group; R 15 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, alkenyl, alkynyl, C 6-10 aryl and heteroaryl, wherein the C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of C 1-12 alkyl, halogen, hydroxy, cyano, amino, nitro, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 18, -OC R 18, -C R 18, -NHC R 18, -S m R 18, -NHC OR 18 and -NHS m R 18; R 16 or R 17 is each independently selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyland heteroaryl, wherein the C 1-12 alkyl, C 3-6 cycloalkyl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of C 1-12 alkyl, halogen, hydroxy, cyano, amino, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, hydroxyC 1-12 alkyl and -OR 18; R 18 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl and hydroxyC 1-12 alkyl; m is 0, 1 or 2; n is 0, 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; s is 0, 1 or 2; and t is 0, 1 or 2; wherein the heteroaryl refers to a heteroaryl system having 1 to 4 heteroatoms selected from the group consisting of O, S and N as ring atoms and having 5 to 10 annular atoms; and wherein the heterocyclyl refers to 3 to 10 membered saturated and/or partially unsaturated monocyclic or polycyclic hydrocarbon group having one or more heteroatoms selected from the group consisting of N, O, and S m. A is CH or N; L is a bond or C 1-12 alkyl; R 1 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 15, -OC R 15, -C R 15, -C NR 16 R 17, -NHC R 15, -NR 16 R 17, -OC NR 16 R 17, -NHC NR 16 R 17 and -S m R 15, wherein the C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of halogen, hydroxy, cyano, nitro, C 1-12 alkyl, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 15, -OC R 15 and -C R 15,; R 2 is C 1-12 alkyl; R 4 is hydrogen; R is selected from the group consisting of hydrogen and halogen; R 3 is selected from the group consisting of hydrogen, halogen and C 1-12 alkyl; R 5 or R 6 is each independently hydrogen; either R 7 or R 8 is each independently hydrogen; R 9 or R 10 is hydrogen; either R 11, R 12, R 13 or R 14 is each hydrogen; or, R 11 and R 12 or R 13 and R 14 are taken together to form an oxo group; R 15 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, alkenyl, alkynyl, C 6-10 aryl and heteroaryl, wherein the C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of C 1-12 alkyl, halogen, hydroxy, cyano, amino, nitro, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, C 6-10 aryl, heteroaryl, -(CH 2) n C OR 18, -OC R 18, -C R 18, -NHC R 18, -S m R 18, -NHC OR 18 and -NHS m R 18; R 16 or R 17 is each independently selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyland heteroaryl, wherein the C 1-12 alkyl, C 3-6 cycloalkyl or heteroaryl is each optionally substituted with one or more groups selected from the group consisting of C 1-12 alkyl, halogen, hydroxy, cyano, amino, C 1-12 alkoxy, C 3-6 cycloalkyl, heterocyclyl, hydroxyC 1-12 alkyl and -OR 18; R 18 is selected from the group consisting of hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, heterocyclyl and hydroxyC 1-12 alkyl; m is 0, 1 or 2; n is 0, 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; s is 0, 1 or 2; and t is 0, 1 or 2; wherein the heteroaryl refers to a heteroaryl system having 1 to 4 heteroatoms selected from the group consisting of O, S and N as ring atoms and having 5 to 10 annular atoms; and wherein the heterocyclyl refers to 3 to 10 membered saturated and/or partially unsaturated monocyclic or polycyclic hydrocarbon group having one or more heteroatoms selected from the group consisting of N, O, and S m.