A security inspection centralized management system, comprising: a central control system (101, 201) connected to a security inspection system and an inspection device at each of a plurality of security checkpoints in a network via the network, so as to realize a network connection between the security inspection systems and the devices at the checkpoints n the network and wherein the management system is configured for fatigue detection and work state monitoring of staff; and wherein the central control system (101,201) comprises: a management system workstation configured to display, monitor and manage security inspection information in real time; the management system further comprising the security inspection system which comprises: an inspection device; an image interpretation workstation; a monitoring system disposed at the inspection device and configured to monitor an inspection scene in real time; a management server located at a node between the security checkpoint and the central control system (101, 201) via the network and configured to summarize, process and upload data of the security checkpoint; the management system further comprising: a fatigue detection system disposed at the security checkpoints and configured to automatically detect an off-the-job state and/or a fatigue degree of a staff in real time, wherein the fatigue detection system is a system based on human body physiological signals and comprises: a smart bracelet worn by the staff and configured to detect and collect physiological signals of different parts of the human body, and make an analysis and a judgement based thereon and transmit the result thereof to a human body physiological signal fatigue determination system, and, a monitoring alarm system configured to monitor the staff in real time and issue an alarm when it is determined, by the fatigue determination system, that the staff is fatigued; and wherein the central control system (101,102) further comprises: the human body physiological signal fatigue determination system which is used for fatigue analysis, judgment and alarm of the staff, and to determine a degree of fatigue of the staff based on a change of the physiological signals, and wherein the physiological signals comprise brain waves in the head, and/or electromyography EMG signals in the arm. an inspection device; an image interpretation workstation; a monitoring system disposed at the inspection device and configured to monitor an inspection scene in real time; a management server located at a node between the security checkpoint and the central control system (101, 201) via the network and configured to summarize, process and upload data of the security checkpoint; a fatigue detection system disposed at the security checkpoints and configured to automatically detect an off-the-job state and/or a fatigue degree of a staff in real time, wherein the fatigue detection system is a system based on human body physiological signals and comprises: a smart bracelet worn by the staff and configured to detect and collect physiological signals of different parts of the human body, and make an analysis and a judgement based thereon and transmit the result thereof to a human body physiological signal fatigue determination system, and, a monitoring alarm system configured to monitor the staff in real time and issue an alarm when it is determined, by the fatigue determination system, that the staff is fatigued; and wherein the central control system (101,102) further comprises: the human body physiological signal fatigue determination system which is used for fatigue analysis, judgment and alarm of the staff, and to determine a degree of fatigue of the staff based on a change of the physiological signals, and wherein the physiological signals comprise brain waves in the head, and/or electromyography EMG signals in the arm. a smart bracelet worn by the staff and configured to detect and collect physiological signals of different parts of the human body, and make an analysis and a judgement based thereon and transmit the result thereof to a human body physiological signal fatigue determination system, and, a monitoring alarm system configured to monitor the staff in real time and issue an alarm when it is determined, by the fatigue determination system, that the staff is fatigued; and wherein the central control system (101,102) further comprises: the human body physiological signal fatigue determination system which is used for fatigue analysis, judgment and alarm of the staff, and to determine a degree of fatigue of the staff based on a change of the physiological signals, and wherein the physiological signals comprise brain waves in the head, and/or electromyography EMG signals in the arm. the human body physiological signal fatigue determination system which is used for fatigue analysis, judgment and alarm of the staff, and to determine a degree of fatigue of the staff based on a change of the physiological signals, and wherein the physiological signals comprise brain waves in the head, and/or electromyography EMG signals in the arm.