Blood isolated ultrafiltration device, comprising: * a filter body, having an inlet port and an outlet port for the blood to be filtered and a discharge port for the extracted waste liquid; * a case extending to form a closed space comprising a room, housing said filter body in a working position, housing a waste liquid collecting bag, and forming, in separated portions thereof, two peristaltic pump rotor chambers (114, 115) of a peristaltic pump means, respectively housing a corresponding peristaltic pump rotor (117, 118); * a delivery flexible hose of the blood to be filtered, connected to said inlet port and to further ducts to be linked to a circulatory system, including a portion thereof arranged inside the first peristaltic pump rotor chamber for obtaining a peristaltic effect for the circulation of blood to be filtered; * a discharge hose of the waste liquid from the filter body, connected to said discharge port, including a portion thereof arranged inside the second peristaltic pump rotor chamber for obtaining a peristaltic effect for the waste liquid circulation; • a blood return hose connected to said outlet port of the filter body, • a basement apt to be rested on a plane, housing a driving means which comprises a pair of electric motors (143, 144) for driving the peristaltic pump rotors (117, 118), each placed axially with a respective drive shaft, said filter body with the delivery flexible hose, the blood return hose and the discharge hose being housed within said case, with the waste liquid collecting bag, said rotor chambers (114, 115) and the corresponding peristaltic pump rotors (117, 118), said case comprising respective engagement holes (121, 122) at the peristaltic pump rotors (117, 118) for the introduction of said respective drive shaft of the basement. * a filter body, having an inlet port and an outlet port for the blood to be filtered and a discharge port for the extracted waste liquid; * a case extending to form a closed space comprising a room, housing said filter body in a working position, housing a waste liquid collecting bag, and forming, in separated portions thereof, two peristaltic pump rotor chambers (114, 115) of a peristaltic pump means, respectively housing a corresponding peristaltic pump rotor (117, 118); * a delivery flexible hose of the blood to be filtered, connected to said inlet port and to further ducts to be linked to a circulatory system, including a portion thereof arranged inside the first peristaltic pump rotor chamber for obtaining a peristaltic effect for the circulation of blood to be filtered; * a discharge hose of the waste liquid from the filter body, connected to said discharge port, including a portion thereof arranged inside the second peristaltic pump rotor chamber for obtaining a peristaltic effect for the waste liquid circulation; • a blood return hose connected to said outlet port of the filter body, • a basement apt to be rested on a plane, housing a driving means which comprises a pair of electric motors (143, 144) for driving the peristaltic pump rotors (117, 118), each placed axially with a respective drive shaft, said filter body with the delivery flexible hose, the blood return hose and the discharge hose being housed within said case, with the waste liquid collecting bag, said rotor chambers (114, 115) and the corresponding peristaltic pump rotors (117, 118), said case comprising respective engagement holes (121, 122) at the peristaltic pump rotors (117, 118) for the introduction of said respective drive shaft of the basement. • a blood return hose connected to said outlet port of the filter body, • a basement apt to be rested on a plane, housing a driving means which comprises a pair of electric motors (143, 144) for driving the peristaltic pump rotors (117, 118), each placed axially with a respective drive shaft, said filter body with the delivery flexible hose, the blood return hose and the discharge hose being housed within said case, with the waste liquid collecting bag, said rotor chambers (114, 115) and the corresponding peristaltic pump rotors (117, 118), said case comprising respective engagement holes (121, 122) at the peristaltic pump rotors (117, 118) for the introduction of said respective drive shaft of the basement.