A compound of Formula, or a pharmaceutically acceptable salt thereof, wherein Formula has the structure: R 1 is selected from hydrogen, halogen, hydroxy, cyano, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl, an unsubstituted C 1 - 4 alkoxy and an unsubstituted C 1 - 4 haloalkoxy; R 2 is an optionally substituted an optionally substituted or an optionally substituted wherein R 2A, R 2B and R 2C are each an optionally substituted bicyclo[1.1.1]pentyl; and when R 2 is substituted, R 2 is substituted by one or more substituents selected from halogen, cyano, an optionally substituted C 1 - 4 alkyl, an optionally substituted C 1 - 4 haloalkyl, an optionally substituted C 1 - 4 alkoxy, an optionally substituted C 3 - 8 cycloalkyl, a mono-substituted amine and a disubstituted amine; R 3 is selected from hydrogen, halogen, an optionally substituted C 1 - 4 alkyl, an optionally substituted C 3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl, wherein when substituted, R 3 is substituted by one or more substituents selected from halogen, cyano, an unsubstituted C 1 - 4 alkyl, an optionally substituted aryl, -C R 5A, -SO 2 R 5B, -NHC R 5C and -(CR 6A R 6B) n NR 7A R 7B; X 1 is O, S or NR 4; R 4 is selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; R 5A, R 5B and R 5C are independently selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl, an optionally substituted C 3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R 6A and R 6B are independently selected from hydrogen, halogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; R 7A and R 7B are independently selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; A 1 is N or CR 8; R 8 is selected from hydrogen, halogen, cyano, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; m is 0 or 1; and n is 0 1, 2 or 3. R 1 is selected from hydrogen, halogen, hydroxy, cyano, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl, an unsubstituted C 1 - 4 alkoxy and an unsubstituted C 1 - 4 haloalkoxy; R 2 is an optionally substituted an optionally substituted or an optionally substituted wherein R 2A, R 2B and R 2C are each an optionally substituted bicyclo[1.1.1]pentyl; and when R 2 is substituted, R 2 is substituted by one or more substituents selected from halogen, cyano, an optionally substituted C 1 - 4 alkyl, an optionally substituted C 1 - 4 haloalkyl, an optionally substituted C 1 - 4 alkoxy, an optionally substituted C 3 - 8 cycloalkyl, a mono-substituted amine and a disubstituted amine; R 3 is selected from hydrogen, halogen, an optionally substituted C 1 - 4 alkyl, an optionally substituted C 3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl, wherein when substituted, R 3 is substituted by one or more substituents selected from halogen, cyano, an unsubstituted C 1 - 4 alkyl, an optionally substituted aryl, -C R 5A, -SO 2 R 5B, -NHC R 5C and -(CR 6A R 6B) n NR 7A R 7B; X 1 is O, S or NR 4; R 4 is selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; R 5A, R 5B and R 5C are independently selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl, an optionally substituted C 3-8 cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R 6A and R 6B are independently selected from hydrogen, halogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; R 7A and R 7B are independently selected from hydrogen, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; A 1 is N or CR 8; R 8 is selected from hydrogen, halogen, cyano, an unsubstituted C 1 - 4 alkyl, an unsubstituted C 1 - 4 haloalkyl and an unsubstituted C 3-8 cycloalkyl; m is 0 or 1; and n is 0 1, 2 or 3.