A hand-held disposable stand-up flexible container, configured for retail sale, wherein the container comprises: a multiple dose product volume that directly contains a fluent product, wherein about all of the product volume is made from one or more films, wherein the term " multiple dose" refers to an amount of product that is about equal to two or more units of typical consumption, application or use; a structural support frame that supports the product volume, wherein the structural support frame includes a plurality of expanded structural support volumes comprising a fillable space made from one or more flexible materials, wherein the space is configured to be at least partially filled with one or more expansion materials, which create tension in the one or more flexible materials, forming the expanded structural support volume; including a first expanded structural support volume, which: is made from one or more films formed into a first leg of a folded gusset; includes a portion that is substantially cylindrical with an overall lateral orientation, and a horizontal reference plane (2001-r) that intersects a longitudinally outermost portion of the first expanded structural support; and characterized in that the first expanded structural support volume also includes a first end, having a first seal that is puckered, such that a first corner of the first seal is offset from the horizontal reference plane (2001-r) when the container is standing up. a multiple dose product volume that directly contains a fluent product, wherein about all of the product volume is made from one or more films, wherein the term " multiple dose" refers to an amount of product that is about equal to two or more units of typical consumption, application or use; a structural support frame that supports the product volume, wherein the structural support frame includes a plurality of expanded structural support volumes comprising a fillable space made from one or more flexible materials, wherein the space is configured to be at least partially filled with one or more expansion materials, which create tension in the one or more flexible materials, forming the expanded structural support volume; including a first expanded structural support volume, which: is made from one or more films formed into a first leg of a folded gusset; includes a portion that is substantially cylindrical with an overall lateral orientation, and a horizontal reference plane (2001-r) that intersects a longitudinally outermost portion of the first expanded structural support; and characterized in that the first expanded structural support volume also includes a first end, is made from one or more films formed into a first leg of a folded gusset; includes a portion that is substantially cylindrical with an overall lateral orientation, and a horizontal reference plane (2001-r) that intersects a longitudinally outermost portion of the first expanded structural support; and characterized in that the first expanded structural support volume also includes a first end, having a first seal that is puckered, such that a first corner of the first seal is offset from the horizontal reference plane (2001-r) when the container is standing up.