A 5-member-heterocycle-fused pyridine compound having a structure of Formula, pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R 1 is substituted or unsubstituted C 6 -C 20 aryl; substituted or unsubstituted 5- to 10-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S; or substituted or unsubstituted 4- to 10-membered heterocyclyl containing 1-5 heteroatoms selected from N, O, and S; wherein, substituent in the substituted group is halogen, nitro, cyano, unsubstituted or halogen- or morpholinyl-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl, -NR a R b, -C (NR a R b), unsubstituted phenyl or phenyl substituted by 1-4 of R 3, or unsubstituted 4- to 7-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S or 4- to 7-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S substituted by 1-4 of R 4; R 2 is substituted or unsubstituted C 6 -C 20 aryl; substituted or unsubstituted 5- to 10-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S; or substituted or unsubstituted 4- to 10-membered heterocyclyl containing 1-5 heteroatoms selected from N, O, and S; wherein substituent(s) in the substituted group(s) is halogen, nitro, cyano, C 1 -C 4 alkylenedioxy, unsubstituted or halogen- or -NR c R d -substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 sulfamido, -NR a R b, -C R', morpholinyl, or unsubstituted or R"-substituted piperidinyl; R 3 is halogen, nitro, cyano, C 1 -C 4 alkylenedioxy, unsubstituted or halogen- or morpholinyl-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, -C R', or morpholinyl; R 4 is halogen, nitro, cyano, unsubstituted or halogen-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, -C R', or unsubstituted or C 1 -C 6 alkoxycarbonyl-substituted piperidinyl; R' is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, or unsubstituted or halogen- or C 1 -C 6 alkyl-substituted 4- to 7-membered heterocyclyl; R" is C 1 -C 6 alkyl; C 3 -C 6 cycloalkyl; C 1 -C 6 alkylcarbonyl; C 1 -C 6 alkoxycarbonyl; C 3 -C 6 cycloalkylcarbonyl; or unsubstituted benzoyl or benzoyl substituted by substituent(s) selected from halogen, C 1 -C 6 alkyl, and halogen-substituted C 1 -C 6 alkyl; R a and R b are each independently H or C 1 -C 6 alkyl; R c and R d are each independently H or C 1 -C 6 alkyl; or, R c and R d, together with the N atom to which they are attached, form 3- to 7-membered heterocyclyl. R 1 is substituted or unsubstituted C 6 -C 20 aryl; substituted or unsubstituted 5- to 10-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S; or substituted or unsubstituted 4- to 10-membered heterocyclyl containing 1-5 heteroatoms selected from N, O, and S; wherein, substituent in the substituted group is halogen, nitro, cyano, unsubstituted or halogen- or morpholinyl-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkylcarbonyl, C 1 -C 6 alkoxycarbonyl, -NR a R b, -C (NR a R b), unsubstituted phenyl or phenyl substituted by 1-4 of R 3, or unsubstituted 4- to 7-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S or 4- to 7-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S substituted by 1-4 of R 4; R 2 is substituted or unsubstituted C 6 -C 20 aryl; substituted or unsubstituted 5- to 10-membered heteroaryl containing 1-5 heteroatoms selected from N, O, and S; or substituted or unsubstituted 4- to 10-membered heterocyclyl containing 1-5 heteroatoms selected from N, O, and S; wherein substituent(s) in the substituted group(s) is halogen, nitro, cyano, C 1 -C 4 alkylenedioxy, unsubstituted or halogen- or -NR c R d -substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 sulfamido, -NR a R b, -C R', morpholinyl, or unsubstituted or R"-substituted piperidinyl; R 3 is halogen, nitro, cyano, C 1 -C 4 alkylenedioxy, unsubstituted or halogen- or morpholinyl-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, -C R', or morpholinyl; R 4 is halogen, nitro, cyano, unsubstituted or halogen-substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, -C R', or unsubstituted or C 1 -C 6 alkoxycarbonyl-substituted piperidinyl; R' is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -NR a R b, or unsubstituted or halogen- or C 1 -C 6 alkyl-substituted 4- to 7-membered heterocyclyl; R" is C 1 -C 6 alkyl; C 3 -C 6 cycloalkyl; C 1 -C 6 alkylcarbonyl; C 1 -C 6 alkoxycarbonyl; C 3 -C 6 cycloalkylcarbonyl; or unsubstituted benzoyl or benzoyl substituted by substituent(s) selected from halogen, C 1 -C 6 alkyl, and halogen-substituted C 1 -C 6 alkyl; R a and R b are each independently H or C 1 -C 6 alkyl; R c and R d are each independently H or C 1 -C 6 alkyl; or, R c and R d, together with the N atom to which they are attached, form 3- to 7-membered heterocyclyl.