Method for preparing a composition comprising resveratrol and curcumin as natural lipophilic compounds, the composition also comprising: - at least one nonionic emulsifier and/or at least one anionic emulsifier, wherein at least one emulsifier is selected from nonionic or anionic surfactants having a hydrophilic-lipophilic balance value (HLB value) of from about 10 to about 16 and a second emulsifier is selected from nonionic or anionic hydrophilic or hydrophobic surfactants having an HLB value of from about 4 to about 12, and - at least one solid matrix-forming agent selected from the group consisting of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus ®), polyvinyl alcohol, crosslinked copolymer of acrylic acid and a hydrophobic C10-C30 alkyl acrylate comonomer, gelatin, hydroxypropyl methylcellulose (Methocel), methylcellulose, hydroxypropylcellulose (Klucel), hydroxyethylcellulose (Natrosol), sodium carboxymethylcellulose, acrylate copolymers, type A or B ammonium methacrylate copolymer, dimethylaminoethyl methacrylate-butyl methacrylate-methyl methacrylate copolymer, methacrylic acid-ethyl acrylate copolymer, polyvinyl alcohol graft copolymer, poly(vinyl acetate-co-crotonic acid), poly(methyl methacrylate) and grafted polyethylene oxide, lignins, poly(vinylpyrrolidone-co-vinyl acetate), polyvinylpyrrolidone, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, hydroxypropyl methylcellulose acetate succinate, polyvinyl acetate phthalate, maltodextrin, dextran, poly(methacrylic acid-co-ethyl acrylate), poly(methacrylic acid-co-methyl methacrylate), polylactic acid, poly-L-lactic acid (PLLA), poly-D-lactic acid (PDLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene oxide-polypropylene oxide block copolymer (Poloxamer), polyethylene glycol (PEG1000, PEG1500, PEG 2000, PEG4000, PEG6000, PEG8000) and mixtures thereof, - wherein resveratrol and curcumin are made soluble in a solid solvent system together with at least one emulsifier and at least one matrix-forming agent, wherein at least 80% of the resveratrol and curcumin, measured by differential scanning calorimetry, is completely dissolved in the solid composition, wherein the method is characterized in that - the composition is prepared by hot-melt extrusion, comprising the steps of supplying the constituents to a hot-melt extruder, mixing, and heating the constituents until they melt, and the subsequent extrusion, cooling and forming, all these steps together forming a single continuous process. - at least one nonionic emulsifier and/or at least one anionic emulsifier, wherein at least one emulsifier is selected from nonionic or anionic surfactants having a hydrophilic-lipophilic balance value (HLB value) of from about 10 to about 16 and a second emulsifier is selected from nonionic or anionic hydrophilic or hydrophobic surfactants having an HLB value of from about 4 to about 12, and - at least one solid matrix-forming agent selected from the group consisting of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus ®), polyvinyl alcohol, crosslinked copolymer of acrylic acid and a hydrophobic C10-C30 alkyl acrylate comonomer, gelatin, hydroxypropyl methylcellulose (Methocel), methylcellulose, hydroxypropylcellulose (Klucel), hydroxyethylcellulose (Natrosol), sodium carboxymethylcellulose, acrylate copolymers, type A or B ammonium methacrylate copolymer, dimethylaminoethyl methacrylate-butyl methacrylate-methyl methacrylate copolymer, methacrylic acid-ethyl acrylate copolymer, polyvinyl alcohol graft copolymer, poly(vinyl acetate-co-crotonic acid), poly(methyl methacrylate) and grafted polyethylene oxide, lignins, poly(vinylpyrrolidone-co-vinyl acetate), polyvinylpyrrolidone, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, hydroxypropyl methylcellulose acetate succinate, polyvinyl acetate phthalate, maltodextrin, dextran, poly(methacrylic acid-co-ethyl acrylate), poly(methacrylic acid-co-methyl methacrylate), polylactic acid, poly-L-lactic acid (PLLA), poly-D-lactic acid (PDLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene oxide-polypropylene oxide block copolymer (Poloxamer), polyethylene glycol (PEG1000, PEG1500, PEG 2000, PEG4000, PEG6000, PEG8000) and mixtures thereof, - wherein resveratrol and curcumin are made soluble in a solid solvent system together with at least one emulsifier and at least one matrix-forming agent, wherein at least 80% of the resveratrol and curcumin, measured by differential scanning calorimetry, is completely dissolved in the solid composition, wherein the method is characterized in that - the composition is prepared by hot-melt extrusion, comprising the steps of supplying the constituents to a hot-melt extruder, mixing, and heating the constituents until they melt, and the subsequent extrusion, cooling and forming, all these steps together forming a single continuous process.