A compound of Formula: or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: W is independently selected from: -Y-R 6, -O-R 6a, -NH-R 6a, -O-Y-R 6, -NH-Y-R 6, and R 6b; Y is independently C 1-8 alkylene or C 2-6 alkynylene, each of which is substituted with 0 to 4 R e; wherein C 1-8 alkylene is optionally interrupted by one O; R 1 and R 3 are, at each occurrence, independently selected from: H, halogen and C 1-4 alkyl; R 4 is independently selected from: H, halogen, C 1-4 alkyl, C 1-4 alkoxy, N(C 1-4 alkyl) 2, and 5-membered heteroaryl including from 1 to 2 ring atoms are each independently selected from N, NH, O, and S; R 6 is independently selected from: H, OH, C 1-6 alkoxy, N(C 1-4 alkyl) 2, C 1-6 haloalkyl, cyano, and R 6a; R 6a is independently selected from: phenyl substituted with 0 to 3 R d; heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R f), O, and S, wherein the heteroaryl is substituted with 0 to 3 R d; C 3-6 cycloalkyl substituted with 0 to 3 R g; heterocyclyl including from 3 to 8 ring atoms, wherein from 1 to 3 ring atoms are each independently selected from N, N(R f), O and S 1-2, wherein the heterocyclyl is substituted with 0 to 3 R g; and R 6b is independently selected from: C 1-6 haloalkyl, cyano, phenyl substituted with 0 to 4 R d; heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R f), O, and S, wherein the heteroaryl is substituted with 0 to 4 R d; C 3-10 cycloalkyl substituted with 0 to 4 R g; and heterocyclyl selected from wherein the heterocyclyl is substituted with 0 to 2 R g; R d is independently selected from: halogen, cyano, OH, -(CH 2) 1-4 OH, C 1-4 alkoxy, C 1-4 haloalkyl, N(C 1-4 alkyl) 2, and C 1-4 alkyl substituted with 0 to 2 C 1-4 alkoxy; R e is independently selected from: F, OH, -(CH 2) 1-4 OH, -CH 2 CONH 2 and C 1-4 alkyl substituted with 0 to 1 C 1-4 alkoxy; R f is independently H or C 1-4 alkyl; and R g is independently oxo or R d. W is independently selected from: -Y-R 6, -O-R 6a, -NH-R 6a, -O-Y-R 6, -NH-Y-R 6, and R 6b; Y is independently C 1-8 alkylene or C 2-6 alkynylene, each of which is substituted with 0 to 4 R e; wherein C 1-8 alkylene is optionally interrupted by one O; R 1 and R 3 are, at each occurrence, independently selected from: H, halogen and C 1-4 alkyl; R 4 is independently selected from: H, halogen, C 1-4 alkyl, C 1-4 alkoxy, N(C 1-4 alkyl) 2, and 5-membered heteroaryl including from 1 to 2 ring atoms are each independently selected from N, NH, O, and S; R 6 is independently selected from: H, OH, C 1-6 alkoxy, N(C 1-4 alkyl) 2, C 1-6 haloalkyl, cyano, and R 6a; R 6a is independently selected from: phenyl substituted with 0 to 3 R d; heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R f), O, and S, wherein the heteroaryl is substituted with 0 to 3 R d; C 3-6 cycloalkyl substituted with 0 to 3 R g; heterocyclyl including from 3 to 8 ring atoms, wherein from 1 to 3 ring atoms are each independently selected from N, N(R f), O and S 1-2, wherein the heterocyclyl is substituted with 0 to 3 R g; and R 6b is independently selected from: C 1-6 haloalkyl, cyano, phenyl substituted with 0 to 4 R d; heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R f), O, and S, wherein the heteroaryl is substituted with 0 to 4 R d; C 3-10 cycloalkyl substituted with 0 to 4 R g; and heterocyclyl selected from wherein the heterocyclyl is substituted with 0 to 2 R g; R d is independently selected from: halogen, cyano, OH, -(CH 2) 1-4 OH, C 1-4 alkoxy, C 1-4 haloalkyl, N(C 1-4 alkyl) 2, and C 1-4 alkyl substituted with 0 to 2 C 1-4 alkoxy; R e is independently selected from: F, OH, -(CH 2) 1-4 OH, -CH 2 CONH 2 and C 1-4 alkyl substituted with 0 to 1 C 1-4 alkoxy; R f is independently H or C 1-4 alkyl; and R g is independently oxo or R d.