A compound of Formula IC: wherein: R 2 is selected from the group consisting of hydrogen, halo, C 1-4 haloalkyl, cyano, NR 2a R 2b, carboxyl, C NR 2a R 2b, OR 2c, unsubstituted or substituted C 1-6 alkyl, unsubstituted or substituted C 3-12 cycloalkyl, unsubstituted or substituted C 3-12 heterocycloalkyl, unsubstituted or substituted C 3-12 aryl, and unsubstituted or substituted C 3-12 heteroaryl; wherein each R 2a, R 2b and R 2c is independently selected from the group consisting of hydrogen, C 1-4 haloalkyl, unsubstituted or substituted C 1-6 alkyl, unsubstituted or substituted C 3-12 cycloalkyl, and unsubstituted or substituted C 3-12 heterocycloalkyl; or R 2a and R 2b and the nitrogen atom to which they are attached join to form unsubstituted or substituted C 3-12 heterocycloalkyl or unsubstituted or substituted C 3-12 heteroaryl; wherein the unsubstituted or substituted C 3-12 heterocycloalkyl or the unsubstituted or substituted C 3-12 heteroaryl has 1 to 3 heteroatoms selected from O, N, and S; W is N or CR w; wherein R w is independently selected from the group consisting of hydrogen, C 1-4 haloalkyl, unsubstituted or substituted C 1-4 alkyl, and unsubstituted or substituted C 1-4 alkoxy; R 5 is hydrogen; R 4 is selected from the group consisting of C 1-8 haloalkyl, unsubstituted or substituted C 1-4 alkyl, unsubstituted or substituted C 3-8 cycloalkyl, unsubstituted or substituted C 3-12 heterocycloalkyl, and unsubstituted or substituted C 3-12 heteroaryl; or a pharmaceutically acceptable salt thereof. R 2 is selected from the group consisting of hydrogen, halo, C 1-4 haloalkyl, cyano, NR 2a R 2b, carboxyl, C NR 2a R 2b, OR 2c, unsubstituted or substituted C 1-6 alkyl, unsubstituted or substituted C 3-12 cycloalkyl, unsubstituted or substituted C 3-12 heterocycloalkyl, unsubstituted or substituted C 3-12 aryl, and unsubstituted or substituted C 3-12 heteroaryl; wherein each R 2a, R 2b and R 2c is independently selected from the group consisting of hydrogen, C 1-4 haloalkyl, unsubstituted or substituted C 1-6 alkyl, unsubstituted or substituted C 3-12 cycloalkyl, and unsubstituted or substituted C 3-12 heterocycloalkyl; or R 2a and R 2b and the nitrogen atom to which they are attached join to form unsubstituted or substituted C 3-12 heterocycloalkyl or unsubstituted or substituted C 3-12 heteroaryl; wherein the unsubstituted or substituted C 3-12 heterocycloalkyl or the unsubstituted or substituted C 3-12 heteroaryl has 1 to 3 heteroatoms selected from O, N, and S; wherein each R 2a, R 2b and R 2c is independently selected from the group consisting of hydrogen, C 1-4 haloalkyl, unsubstituted or substituted C 1-6 alkyl, unsubstituted or substituted C 3-12 cycloalkyl, and unsubstituted or substituted C 3-12 heterocycloalkyl; or R 2a and R 2b and the nitrogen atom to which they are attached join to form unsubstituted or substituted C 3-12 heterocycloalkyl or unsubstituted or substituted C 3-12 heteroaryl; wherein the unsubstituted or substituted C 3-12 heterocycloalkyl or the unsubstituted or substituted C 3-12 heteroaryl has 1 to 3 heteroatoms selected from O, N, and S; W is N or CR w; wherein R w is independently selected from the group consisting of hydrogen, C 1-4 haloalkyl, unsubstituted or substituted C 1-4 alkyl, and unsubstituted or substituted C 1-4 alkoxy; R 5 is hydrogen; R 4 is selected from the group consisting of C 1-8 haloalkyl, unsubstituted or substituted C 1-4 alkyl, unsubstituted or substituted C 3-8 cycloalkyl, unsubstituted or substituted C 3-12 heterocycloalkyl, and unsubstituted or substituted C 3-12 heteroaryl; or a pharmaceutically acceptable salt thereof.