A biopsy system driver, comprising: a motor having a rotatable output shaft; a support structure (12, 14); a drive shaft rotatably coupled to the support structure (12, 14), wherein the drive shaft comprises an adapter operatively coupled to the motor output shaft, such that activation of the motor rotates the drive shaft, or wherein the drive shaft comprises the motor output shaft and an adapter, such that activation of the motor rotates the drive shaft and the adapter; an elongate lead screw coupled to the drive shaft such that rotation of the drive shaft rotates the lead screw about an axis of the lead screw, the lead screw being axially translatable relative to the drive shaft and to the support structure (12, 14); and a biopsy instrument drive member (34, 46) threadably coupled to the lead screw such that rotation of the lead screw causes axial translation of one of the lead screw and biopsy instrument drive member (34, 46) relative to the other one and to the support structure (12, 14), the biopsy instrument drive member (34, 46) comprising an outer cannula drive member, an inner cannula drive member; wherein, the lead screw has a proximal axial inner bore into which a distal portion of the adapter extends, wherein the lead screw is configured to axially translate over the distal portion of the adapter, relative to the drive shaft and to the support structure (12, 14): and the biopsy instrument drive member (34, 46) comprises an elongate cam (60; 200) rotatably coupled to the support structure (12, 14), wherein the cam is configured to releasably and operatively couple to the outer cannula drive member and the inner cannula drive member to control axial movement thereof. a motor having a rotatable output shaft; a support structure (12, 14); a drive shaft rotatably coupled to the support structure (12, 14), wherein the drive shaft comprises an adapter operatively coupled to the motor output shaft, such that activation of the motor rotates the drive shaft, or wherein the drive shaft comprises the motor output shaft and an adapter, such that activation of the motor rotates the drive shaft and the adapter; an elongate lead screw coupled to the drive shaft such that rotation of the drive shaft rotates the lead screw about an axis of the lead screw, the lead screw being axially translatable relative to the drive shaft and to the support structure (12, 14); and a biopsy instrument drive member (34, 46) threadably coupled to the lead screw such that rotation of the lead screw causes axial translation of one of the lead screw and biopsy instrument drive member (34, 46) relative to the other one and to the support structure (12, 14), the biopsy instrument drive member (34, 46) comprising an outer cannula drive member, an inner cannula drive member; wherein, the lead screw has a proximal axial inner bore into which a distal portion of the adapter extends, wherein the lead screw is configured to axially translate over the distal portion of the adapter, relative to the drive shaft and to the support structure (12, 14): and the biopsy instrument drive member (34, 46) comprises an elongate cam (60; 200) rotatably coupled to the support structure (12, 14), wherein the cam is configured to releasably and operatively couple to the outer cannula drive member and the inner cannula drive member to control axial movement thereof.