mhurhangee/ep-ind-claims huggingface dataset:
A polypeptide comprising: (a) a heavy chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; (b) a first light chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; and (c) at least one further light chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; wherein the domains are connected via a covalent bond, a peptide-linker, a chemical linker, a disulfide bond, or a combination of two or more thereof, wherein the first and the at least one further LC domain may be the same or different from each other, and wherein each of said fragments of said first and of said at least one further LC domain exhibits proteolytic activity of more than 10 % of the corresponding wild-type LC domain in a SNAP-25 assay, and the fragment of the HC domain is capable of binding to the receptor of the native HC domain from which it is derived, and is also capable of translocating a LC domain attached to it. (a) a heavy chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; (b) a first light chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; and (c) at least one further light chain domain, or fragment thereof, of the neurotoxic component of a clostridial toxin; wherein the domains are connected via a covalent bond, a peptide-linker, a chemical linker, a disulfide bond, or a combination of two or more thereof, wherein the first and the at least one further LC domain may be the same or different from each other, and wherein each of said fragments of said first and of said at least one further LC domain exhibits proteolytic activity of more than 10 % of the corresponding wild-type LC domain in a SNAP-25 assay, and the fragment of the HC domain is capable of binding to the receptor of the native HC domain from which it is derived, and is also capable of translocating a LC domain attached to it.
A dust collector, in which a main body including an electric blower is provided in an upper part of a tank having a suction port, air that is drawn through the suction port from outside by the electric blower is discharged through the tank and the main body, and a filter (20, 22, 23) that separates the suction port from the main body in an intake path extending from the suction port to the electric blower and that is capable of catching dust in the outside air is provided in the tank, a pair of the intake paths in which air flows respectively through a pair of the filters (20, 22, 23) projecting within the tank are formed so as to be combined together on an upstream side of the electric blower, a pair of communication paths (50, 51) are formed so as to allow a discharge passage on a downstream side of the electric blower to communicate with each of the intake paths, first opening and closing members (55, 55') are each provided on a downstream side of the communication path (50, 51) in the intake path, are capable of opening and closing the intake path, and are biased, in a normal state, to a position where the first opening and closing member opens the intake path, second opening and closing members (61, 61') are each provided in the communication path (50, 51), are capable of opening and closing the communication path (50, 51), are biased, in the normal state, to a position where the second opening and closing member (61, 61') closes the communication path (50, 51), and open the communication path (50, 51) in response to a closing operation of closing the intake path by the first opening and closing member (55, 55'), and an operation unit is provided that is capable of alternately causing the first opening and closing members (55, 55') in the intake paths to perform the closing operation, characterized in that when the operation unit causes one of the first opening and closing members (55, 55') to perform the closing operation and thus causes the second opening and closing member (61, 61') to open the communication path (50, 51), discharged air in the discharge passage is guided to one of the intake paths via the communication path (50, 51), the discharged air is caused to flow backward in the intake path and returned to the tank through the filter (20, 22, 23), and is guided to the other intake path, so that the dust on the filter (20, 22, 23) of the one intake path is removed, and the operation unit includes a motor placed between the pair of first opening and closing members (55, 55'), and a cam member provided on an output shaft of the motor and formed to alternately contact the first opening and closing members (55, 55') respectively in response to rotation of the output shaft so that the first opening and closing members (55, 55') perform the closing operation.
A peptide set forth in the following SEQ ID NO: 1, wherein the peptide binds to a transcription factor CP2c and has prophylactic and therapeutic activities against cancer: <SEQ ID NO: 1> Tyr-Pro-Gln-Arg wherein acetyl and amide groups are bound to N-terminal Tyr and C-terminal Arg of the peptide set forth in SEQ ID NO: 1, respectively.
A multilayer film for manufacturing a pouch, said multilayer film comprising: - a core layer, and - an outer layer, wherein: - the outer layer and the core layer are made integral with a tie layer, - the core layer comprises an ethylene vinyl alcohol copolymer having a content of ethylene in the range of 25 to 48 mol %, alone or in mixture with an ionomer acid ethylene copolymer, - the outer layer comprises a mixture of a polyolefin having a density in the range of 0.910 g/cm3 to 0.940 g/cm 3 and a copolymer of ethylene and α-olefin having a density in the range of 0.870 g/cm3 to 0.910 g/cm3, - the tie layer comprises a copolymer of polyolefin grafted with a carboxylic acid or an anhydride of carboxylic acid, alone or in mixture with a copolymer of polyolefin. - a core layer, and - an outer layer, - the outer layer and the core layer are made integral with a tie layer, - the core layer comprises an ethylene vinyl alcohol copolymer having a content of ethylene in the range of 25 to 48 mol %, alone or in mixture with an ionomer acid ethylene copolymer, - the outer layer comprises a mixture of a polyolefin having a density in the range of 0.910 g/cm3 to 0.940 g/cm 3 and a copolymer of ethylene and α-olefin having a density in the range of 0.870 g/cm3 to 0.910 g/cm3, - the tie layer comprises a copolymer of polyolefin grafted with a carboxylic acid or an anhydride of carboxylic acid, alone or in mixture with a copolymer of polyolefin.
A tube with a tube head and a container made of resilient material, wherein the tube head is connected to the container, wherein the tube head comprises a female Luer lock fitting with a flow passage, the female Luer lock fitting being designed for sealingly receiving a male Luer lock fitting of a syringe, and wherein a tamper-evident closure (11; 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting such that it closes the flow passage in a closed state of the tube, characterized in that the tamper-evident closure comprises a lid that is sealingly arranged at the inner surface of the female Luer lock fitting in a closed state of the tube such that it closes the flow passage, with the lid being connected to the inner surface of the female Luer lock fitting through a hinge and a predetermined breaking line that connects to the hinge, wherein a receiving space is provided in the inner surface of the female Luer lock fitting for receiving the lid in an open state of the tube.
A method performed by a Product Data Management data processing system for providing hybrid hidden-line processing for a plurality of polygons representing tessellated image data, each polygon comprising a plurality of edges, the method comprising: identifying by a silhouette generator a back-facing plate comprising polygons on a back-facing side of a silhouette of the tessellated image data and a front-facing plate comprising polygons on a front-facing side of the silhouette of the tessellated image data; labeling the polygons of the identified facing plates as such in a memory; performing a Z-depth polygon scan conversion, identifying external edges and silhouette edges of the polygons and storing the converted and identified data into a Z-Buffer; marking pixels in the Z-Buffer that are part of silhouette edges or external edges; tracing the silhouette edges or external edges; identifying at least one visibility change pixel in each of a subset of the traced edges; for each visibility change pixel, determining whether the traced edge is from the same plate as a polygon corresponding to the visibility change pixel; and for each traced edge that is determined to be from the same plate as the polygon corresponding to the visibility change pixel, displaying the traced edge. identifying by a silhouette generator a back-facing plate comprising polygons on a back-facing side of a silhouette of the tessellated image data and a front-facing plate comprising polygons on a front-facing side of the silhouette of the tessellated image data; labeling the polygons of the identified facing plates as such in a memory; performing a Z-depth polygon scan conversion, identifying external edges and silhouette edges of the polygons and storing the converted and identified data into a Z-Buffer; marking pixels in the Z-Buffer that are part of silhouette edges or external edges; tracing the silhouette edges or external edges; identifying at least one visibility change pixel in each of a subset of the traced edges; for each visibility change pixel, determining whether the traced edge is from the same plate as a polygon corresponding to the visibility change pixel; and for each traced edge that is determined to be from the same plate as the polygon corresponding to the visibility change pixel, displaying the traced edge.
A device for decreasing the temperature of a sample comprising: (a) a carrier substrate with a lower side for accommodating a sample and with an upper side, which is exposed for a supply of a liquid; (b) a pressure tank adapted for holding a fluid, the pressure tank comprising an outlet valve located at the bottom; (c) a supply line connecting the outlet valve with the upper side of the carrier substrate, wherein the supply line is adapted to pass the liquid with a pressure higher than the atmospheric pressure through it; and (d) an expansion chamber surrounding the upper side of the carrier substrate, wherein the pressure tank is mounted to the upper side of the carrier substrate, to keep the supply line as short as possible. (a) a carrier substrate with a lower side for accommodating a sample and with an upper side, which is exposed for a supply of a liquid; (b) a pressure tank adapted for holding a fluid, the pressure tank comprising an outlet valve located at the bottom; (c) a supply line connecting the outlet valve with the upper side of the carrier substrate, wherein the supply line is adapted to pass the liquid with a pressure higher than the atmospheric pressure through it; and (d) an expansion chamber surrounding the upper side of the carrier substrate,
A secondary synthetic method for calcium sulphoaluminate mineral in Portland cement clinker, wherein it consists of the following steps: Plaster is added to Portland cement raw meal so that the SO 3 content of raw meal is 0.5 - 6.0 wt.-%; the prepared raw meal is calcinated, the temperature is increased to 1400 - 1600 °C at a rate of 1 - 25°C per minute and is kept at said temperature, and then it is naturally cooled; the cooled clinker is heated to 800 -1300 °C at a rate of 1 - 25°C per minute, and kept at said temperature, and then it is naturally cooled; said cooled clinker is ground to powder with the aid of ball mill; or it consists of the following steps: plaster is added to Portland cement raw meal so that the SO 3 content of raw meal is 0.5 - 6.0 wt.-%; said prepared raw meal is calcinated, the temperature is increased to 1400 - 1600 °C at a rate of 1 - 25 °C per minute, and kept at said temperature, and then it is transferred to a cooler, the temperature is cooled at a rate of 40 - 80°C per minute; keep the temperature when it is cooled to 800 - 1300 °C, and then it is naturally cooled; the said cooled cement clinker is ground to powder with the aid of ball mill. Plaster is added to Portland cement raw meal so that the SO 3 content of raw meal is 0.5 - 6.0 wt.-%; the prepared raw meal is calcinated, the temperature is increased to 1400 - 1600 °C at a rate of 1 - 25°C per minute and is kept at said temperature, and then it is naturally cooled; the cooled clinker is heated to 800 -1300 °C at a rate of 1 - 25°C per minute, and kept at said temperature, and then it is naturally cooled; said cooled clinker is ground to powder with the aid of ball mill; or it consists of the following steps: plaster is added to Portland cement raw meal so that the SO 3 content of raw meal is 0.5 - 6.0 wt.-%; said prepared raw meal is calcinated, the temperature is increased to 1400 - 1600 °C at a rate of 1 - 25 °C per minute, and kept at said temperature, and then it is transferred to a cooler, the temperature is cooled at a rate of 40 - 80°C per minute; keep the temperature when it is cooled to 800 - 1300 °C, and then it is naturally cooled; the said cooled cement clinker is ground to powder with the aid of ball mill. plaster is added to Portland cement raw meal so that the SO 3 content of raw meal is 0.5 - 6.0 wt.-%; said prepared raw meal is calcinated, the temperature is increased to 1400 - 1600 °C at a rate of 1 - 25 °C per minute, and kept at said temperature, and then it is transferred to a cooler, the temperature is cooled at a rate of 40 - 80°C per minute; keep the temperature when it is cooled to 800 - 1300 °C, and then it is naturally cooled; the said cooled cement clinker is ground to powder with the aid of ball mill.
An ophthalmic instrument for the measurement of ocular refraction and visual simulation, that enables binocular simultaneous presentation of visual stimuli and their perception through different phase profiles or aberrations, that comprises: - a system of presentation of binocular stimuli which in turn comprises two input pupils, - a first output pupil and a second output pupil, and - only one phase modulator, which is optically conjugated with the two input pupils and the two output pupils (14, 15) of the instrument, wherein the one phase modulator is configured to manipulate the phase of the incident radiation for the first output pupil and the phase of the incident radiation for the second output pupil, and wherein operations of the measurement of refraction, and simulation of ophthalmic elements or visual conditions can be done in binocular manner. - a system of presentation of binocular stimuli which in turn comprises two input pupils, - a first output pupil and a second output pupil, and - only one phase modulator, which is optically conjugated with the two input pupils and the two output pupils (14, 15) of the instrument,
A method for identifying visual media content presented by an external display for viewing by a user, wherein the method is performed by a mobile device, the method comprising: receiving an image from a camera of the mobile device; detecting, after receiving said image, a quadrilateral contained within the image and corresponding to the external display; and capturing visual media content contained within the quadrilateral for identifying the visual media content, wherein detecting the quadrilateral contained within the image further comprises receiving a user input relative to a portion of a viewfinder depiction of the image; and wherein detecting the quadrilateral contained within the image further comprises creating a region of interest map; and cropping the image to encompass the region of interest map, wherein creating the region of interest map comprises creating a glowing region of interest map by thresholding maximum illumination. receiving an image from a camera of the mobile device; detecting, after receiving said image, a quadrilateral contained within the image and corresponding to the external display; and capturing visual media content contained within the quadrilateral for identifying the visual media content, wherein detecting the quadrilateral contained within the image further comprises receiving a user input relative to a portion of a viewfinder depiction of the image; and wherein detecting the quadrilateral contained within the image further comprises creating a region of interest map; and cropping the image to encompass the region of interest map, wherein creating the region of interest map comprises creating a glowing region of interest map by thresholding maximum illumination.
Timepiece display mechanism including at least one display member that moves in jumps, said mechanism including at least one spring between a first wheel set and a second wheel set,said first wheel set or respectively said second wheel set being arranged to be driven by a drive wheel set, wherein said second wheel set or respectively said first wheel set is arranged to drive or carry a peripheral snail cam traversed by a feeler arranged to control the jump of a said display member, and wherein said mechanism includes locking/release means including, on the one hand at least one finger driven by said second wheel set or respectively said first wheel set, and on the other hand, a third wheel set arranged, depending on its angular position, to stop or release said at least one finger, to prevent or respectively allow rotation of said cam, characterized in that said third wheel set is an anchor piece angularly movable about an anchor piece axis under the action of said first wheel set or respectively of said second wheel set, said anchor piece being arranged, depending on its angular position, to stop or release said at least one finger, to prevent or respectively allow rotation of said cam.
A levered landing gear, comprising: a first shock strut having a longitudinal axis, the first shock strut including a first stop pad having a first contact surface; a second shock strut disposed concentrically with the first shock strut along the longitudinal axis such that the first shock strut and the second shock strut extend along a shared extension axis; a truck lever coupled to the first shock strut and the second shock strut such that the second shock strut pivots the truck lever relative to the first shock strut, the truck lever including a second stop pad having a second contact surface, wherein the truck lever pivots between an extended position and a static position relative to the first shock strut, and wherein the first contact surface makes physical contact with the second contact surface when the truck lever is in the static position to form a stop joint for the levered landing gear; and a first sensor (210, 310, 410) disposed with the levered landing gear and configured to measure a first condition of the stop joint. a first shock strut having a longitudinal axis, the first shock strut including a first stop pad having a first contact surface; a second shock strut disposed concentrically with the first shock strut along the longitudinal axis such that the first shock strut and the second shock strut extend along a shared extension axis; a truck lever coupled to the first shock strut and the second shock strut such that the second shock strut pivots the truck lever relative to the first shock strut, the truck lever including a second stop pad having a second contact surface, wherein the truck lever pivots between an extended position and a static position relative to the first shock strut, and wherein the first contact surface makes physical contact with the second contact surface when the truck lever is in the static position to form a stop joint for the levered landing gear; and a first sensor (210, 310, 410) disposed with the levered landing gear and configured to measure a first condition of the stop joint.
Engine comprising a propeller unit with a pair of contrarotating propellers (31, 32), a gas generator supplying a power turbine, the pair of propellers (31, 32) being rotationally driven by the shaft of the power turbine via a speed reduction gearbox (6, 7), the axis of rotation of the pair of propellers (31, 32) not being coaxial with that of the power turbine, the speed reduction gearbox (6, 7) comprising a differential gearset and a first stage comprising a simple gearset connecting the turbine shaft and the differential gearset, the air intake of the engine comprising an air intake duct, the air intake duct being in the shape of a lobe adjacent to the assembly formed by the simple gearset and the differential gearset, wherein the first stage with a simple gearset comprises a first toothed wheel, integral with the turbine shaft, said first toothed wheel meshing with a second toothed wheel of the first stage, said second toothed wheel being mounted so as to rotate about the axis of the pair of propellers.
A device for adaptive roadmapping for examination of an object of interest, comprising - a processing unit; - an interface unit; and - a display; wherein the interface unit is adapted to provide pre-navigation image data that represents at least a part of a vascular structure comprising a tree-like structure with a plurality of sub-trees; and to provide live image data of the object, which object comprises the vascular structure; wherein the vascular structure contains an element of interest; and wherein the processing unit is adapted to generate a vessel representation on the basis of the pre-navigation image data; to determine spatial relation of the pre-navigation image data and live image data; to analyze the live image data by identifying and localizing the element in the live image data; to determine a sub-tree in which the element is positioned, wherein the determining is based on the localization of the element and on the spatial relation, and to select a portion of the vascular structure based on the determined sub-tree; and to generate a combination of the live image data and an image of the selected portion of the vascular structure; wherein the display is adapted to display the combination as a tailored roadmap. - a processing unit; - an interface unit; and - a display; wherein the interface unit is adapted to provide pre-navigation image data that represents at least a part of a vascular structure comprising a tree-like structure with a plurality of sub-trees; and to provide live image data of the object, which object comprises the vascular structure; wherein the vascular structure contains an element of interest; and wherein the processing unit is adapted to generate a vessel representation on the basis of the pre-navigation image data; to determine spatial relation of the pre-navigation image data and live image data; to analyze the live image data by identifying and localizing the element in the live image data; to determine a sub-tree in which the element is positioned, wherein the determining is based on the localization of the element and on the spatial relation, and to select a portion of the vascular structure based on the determined sub-tree; and to generate a combination of the live image data and an image of the selected portion of the vascular structure; wherein the display is adapted to display the combination as a tailored roadmap.
A bi-directional tractor exhaust system (102, 202), comprising: a downwardly directed exhaust pipe connected to an upwardly directed exhaust pipe; an exhaust pipe valve; and an actuator connected to the exhaust pipe valve (108, 212) and moveable between a first position opening the exhaust pipe valve to direct exhaust through the downwardly directed exhaust pipe, and a second position closing the exhaust pipe valve (108, 212) to direct exhaust through the upwardly directed exhaust pipe. a downwardly directed exhaust pipe connected to an upwardly directed exhaust pipe; an exhaust pipe valve; and an actuator connected to the exhaust pipe valve (108, 212) and moveable between a first position opening the exhaust pipe valve to direct exhaust through the downwardly directed exhaust pipe, and a second position closing the exhaust pipe valve (108, 212) to direct exhaust through the upwardly directed exhaust pipe.