A compound according to Formula: wherein: R represents: C 2-6 alkyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkenyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkynyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -C 3-6 carbocycle optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -R4 where R4 is phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole; R4 is optionally substituted by one or more: Cl, Br, I, C 1-3 alkyl optionally substituted by one to three F, or C 1-2 alkoxy optionally substituted by one to three F; R1 represents: hydrogen; C 1-6 alkyl optionally substituted by hydroxy, halogen, amino, guanidino, phenyl, pyridyl, pyrrolyl, indolyl, imidazolyl, furanyl, benzofuranyl, piperidinyl, morpholinyl, quinoliriyl, piperazinyl or dimethylaminophenyl; or (CH 2) n -C 3-7 carbocycle; R2 represents: hydrogen (provided that X is not O), C 1-3 substituted alkyl, C 2-3 substituted alkenyl, C 2-3 substituted alkynyl, (CH 2) n -C 3-6 substituted carbocycle, aryl, heteroaryl, heterocyclic, carboxy (provided that X is not NR3 or O) or aminocarbonyl (provided that X is not NR3 or O); R3 represents: hydrogen, C 1-3 substituted alkyl, phenyl, or may be taken together with R2 and the nitrogen atom to which they are attached to form an optionally substituted heterocyclic ring which is optionally fused to an aryl, a heteroaryl, or a second heterocyclic ring; X represents O, NR3 or a covalent bond; Y represents O, CH 2 or a covalent bond; n = 0-2; or a salt or solvate thereof. R represents: C 2-6 alkyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkenyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkynyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -C 3-6 carbocycle optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -R4 where R4 is phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole; R4 is optionally substituted by one or more: Cl, Br, I, C 1-3 alkyl optionally substituted by one to three F, or C 1-2 alkoxy optionally substituted by one to three F; C 2-6 alkyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkenyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; C 2-6 alkynyl optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -C 3-6 carbocycle optionally substituted by alkoxy, halogen, or C 1-3 alkylsulfanyl; (CH 2) n -R4 where R4 is phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole; R4 is optionally substituted by one or more: Cl, Br, I, C 1-3 alkyl optionally substituted by one to three F, or C 1-2 alkoxy optionally substituted by one to three F; R1 represents: hydrogen; C 1-6 alkyl optionally substituted by hydroxy, halogen, amino, guanidino, phenyl, pyridyl, pyrrolyl, indolyl, imidazolyl, furanyl, benzofuranyl, piperidinyl, morpholinyl, quinoliriyl, piperazinyl or dimethylaminophenyl; or (CH 2) n -C 3-7 carbocycle; hydrogen; C 1-6 alkyl optionally substituted by hydroxy, halogen, amino, guanidino, phenyl, pyridyl, pyrrolyl, indolyl, imidazolyl, furanyl, benzofuranyl, piperidinyl, morpholinyl, quinoliriyl, piperazinyl or dimethylaminophenyl; or (CH 2) n -C 3-7 carbocycle; R2 represents: hydrogen (provided that X is not O), C 1-3 substituted alkyl, C 2-3 substituted alkenyl, C 2-3 substituted alkynyl, (CH 2) n -C 3-6 substituted carbocycle, aryl, heteroaryl, heterocyclic, carboxy (provided that X is not NR3 or O) or aminocarbonyl (provided that X is not NR3 or O); hydrogen (provided that X is not O), C 1-3 substituted alkyl, C 2-3 substituted alkenyl, C 2-3 substituted alkynyl, (CH 2) n -C 3-6 substituted carbocycle, aryl, heteroaryl, heterocyclic, carboxy (provided that X is not NR3 or O) or aminocarbonyl (provided that X is not NR3 or O); R3 represents: hydrogen, C 1-3 substituted alkyl, phenyl, or may be taken together with R2 and the nitrogen atom to which they are attached to form an optionally substituted heterocyclic ring which is optionally fused to an aryl, a heteroaryl, or a second heterocyclic ring; hydrogen, C 1-3 substituted alkyl, phenyl, or may be taken together with R2 and the nitrogen atom to which they are attached to form an optionally substituted heterocyclic ring which is optionally fused to an aryl, a heteroaryl, or a second heterocyclic ring; X represents O, NR3 or a covalent bond; Y represents O, CH 2 or a covalent bond; n = 0-2; or a salt or solvate thereof.