mhurhangee/ep-ind-claims huggingface dataset:
A method of determining microsatellite instability comprising: attaching a plurality of sets of non-unique exogenous barcodes to fragments of cell-free DNA (cfDNA) from a liquid biopsy obtained from a patient so that each cfDNA fragment is attached to a non-unique barcode; amplifying the fragments to produce amplicons that include barcode information and copies of the fragments; sequencing the amplicons to obtain sequences of a plurality of tracts of nucleotide repeats in the cfDNA, wherein the obtained sequences include a plurality of sequence reads; performing a first alignment of the plurality of sequence reads with a reference sequence; identifying groups of sequence reads that originated from a unique cfDNA fragment by means of the barcode information and position or content of the sequence reads; performing a second local alignment of the plurality of sequence reads at microsatellite loci with the reference sequence to determine indel length; aggregating groups of sequence reads according to the first alignment and second local alignment; performing error correction using the non-unique exogenous barcodes on the aggregated groups of sequence reads to identify local peaks from a length distribution plot of nucleotide repeat lengths from each aggregated group of corrected sequence reads; and providing a report describing an MSI status of the patient depicting a distribution of lengths of the plurality of tracts that have peaks that deviate from peaks in a reference distribution. attaching a plurality of sets of non-unique exogenous barcodes to fragments of cell-free DNA (cfDNA) from a liquid biopsy obtained from a patient so that each cfDNA fragment is attached to a non-unique barcode; amplifying the fragments to produce amplicons that include barcode information and copies of the fragments; sequencing the amplicons to obtain sequences of a plurality of tracts of nucleotide repeats in the cfDNA, wherein the obtained sequences include a plurality of sequence reads; performing a first alignment of the plurality of sequence reads with a reference sequence; identifying groups of sequence reads that originated from a unique cfDNA fragment by means of the barcode information and position or content of the sequence reads; performing a second local alignment of the plurality of sequence reads at microsatellite loci with the reference sequence to determine indel length; aggregating groups of sequence reads according to the first alignment and second local alignment; performing error correction using the non-unique exogenous barcodes on the aggregated groups of sequence reads to identify local peaks from a length distribution plot of nucleotide repeat lengths from each aggregated group of corrected sequence reads; and providing a report describing an MSI status of the patient depicting a distribution of lengths of the plurality of tracts that have peaks that deviate from peaks in a reference distribution.
A gas delivery mask (10, 57) comprising: a shell (14, 14', 14", 62) for supporting a cushion, the cushion is configured to contact a patient and deliver a gas to the patient; a pair of first connectors (28, 28', 28", 60), one first connector arranged on each side of the shell; a pair of second connectors (42, 42', 74) adapted to be connected to a headgear, wherein the headgear includes at least one strap adapted to secure the mask on a patient; and characterized by means for releasably connecting each of the pair of first connectors with a respective one of the pair of second connectors such that the second connectors are rotateable relative to the first connectors in a plurality of axis of rotation simultaneously, whereby the first connector and the respective second connector interact to realeasably interconnect the shell with the headgear.
Cooking appliance, in particular oven, with a cooking compartment that can be closed off, in which a fan chamber is embodied between a cooking compartment wall (2, 3) and a baffle wall, in which a fan wheel is arranged which draws air into the fan chamber through at least one suction opening of the baffle wall and expels it from the fan chamber through at least one exhaust opening of the baffle wall, wherein the baffle wall has an air conducting section arranged substantially at right angles, which forms a frame-like edge of the baffle wall, wherein the at least one exhaust opening is arranged on the air conducting section and the at least one exhaust opening has a length and a depth, characterised in that the depth has a varying extent over the course of the length, wherein, in a top view of the air conducting section of the baffle wall, the depth is to be understood as meaning a width of the exhaust opening at right angles to the length, and wherein the varying extent of the depth is to be understood as meaning that a geometry of the exhaust opening varies over the course of the length in such a way that a cross-section of the exhaust opening varies over the course of the length.
A flanging press for folding over a flange of a component, preferably a vehicle part, wherein the flanging press is arranged in a stationary manner and comprises at least: (a) a base structure featuring a flanging bed onto which the component (B 1) can be pressed in a pressing direction in order to fold over the flange; (b) a flanging die unit featuring a flanging die for folding over the flange; (c) and a pressing drive for generating a pressing force which acts on the component (B 1) for the purpose of folding over, (d) wherein the flanging die and the flanging bed can be moved relative to each other in the pressing direction by means of the pressing drive in order to exert the pressing force, (e) and wherein the base structure and the flanging die unit are at least substantially installed vertically upright or mounted such that they can be installed vertically upright, such that the flanging bed points in the pressing direction which is at least substantially horizontal, characterised in that (f) the flanging die unit comprises a passage through which the component (B 1) can be inserted into the flanging bed from a rear side of the flanging die unit which faces away from the flanging bed, and the flanging die is arranged on an inner circumference of the passage. (a) a base structure featuring a flanging bed onto which the component (B 1) can be pressed in a pressing direction in order to fold over the flange; (b) a flanging die unit featuring a flanging die for folding over the flange; (c) and a pressing drive for generating a pressing force which acts on the component (B 1) for the purpose of folding over, (d) wherein the flanging die and the flanging bed can be moved relative to each other in the pressing direction by means of the pressing drive in order to exert the pressing force, (e) and wherein the base structure and the flanging die unit are at least substantially installed vertically upright or mounted such that they can be installed vertically upright, such that the flanging bed points in the pressing direction which is at least substantially horizontal, characterised in that (f) the flanging die unit comprises a passage through which the component (B 1) can be inserted into the flanging bed from a rear side of the flanging die unit which faces away from the flanging bed, and the flanging die is arranged on an inner circumference of the passage.
A power transmission device (3, 3a) for wirelessly transmitting power to a power reception device, the power transmission device comprising: a first coil (33, 43) configured to emit a first electromagnetic wave to the power reception device; and second correction coils that are arranged at a position where a center axis of the first coil (33, 43) and each center axis of the second correction coils do not overlap each other and the second correction coils are configured to emit a second electromagnetic wave having a strength distribution with a polarity opposite to a polarity of a strength distribution of the first electromagnetic wave and having a smaller electromagnetic strength than an electromagnetic strength of the first electromagnetic wave emitted by the first coil (33, 43). a first coil (33, 43) configured to emit a first electromagnetic wave to the power reception device; and second correction coils that are arranged at a position where a center axis of the first coil (33, 43) and each center axis of the second correction coils do not overlap each other and the second correction coils are configured to emit a second electromagnetic wave having a strength distribution with a polarity opposite to a polarity of a strength distribution of the first electromagnetic wave and having a smaller electromagnetic strength than an electromagnetic strength of the first electromagnetic wave emitted by the first coil (33, 43).
A lifting/sliding door having a door leaf and a fixed frame, the fixed frame comprising an upper fixed frame profile which has a lower fixed frame profile underside which faces the door leaf and has a fixed frame profile groove in which a first guide profile rail having a first longitudinal extent is arranged, the door leaf further having an upper door leaf frame profile, which has a door leaf profile upper side which faces the upper fixed frame profile and has a door leaf profile groove in which a second guide profile rail is arranged which has a second longitudinal extent in the direction of the first longitudinal extent, and guide slides being arranged in the second guide profile rail, the guide slides sliding on the first guide profile rail, characterized in that a third guide profile rail is arranged between the guide slides, the third guide profile rail having a third longitudinal extent in the direction of the second longitudinal extension of the second guide profile rail, and the third guide profile rail extending up into the first guide profile rail and being arranged at a distance from the first guide profile rail, and in that the guide slides are formed at least approximately U-shaped with two limbs (36, 37), the third guide profile rail being arranged between the two limbs (36, 37).
Method for the transmission of position information by a mobile device consisting in acquiring, on board the mobile device, position information of the mobile device from GNSS navigation signals transmitted by a satellite constellation (5a, 5b, 5c) and in transmitting the position information to a position server, characterized in that it consists: - starting from an initial time t 0 and at successive times t i greater than t 0 and spaced by a period Tv, in periodically measuring pseudo-distances (d1, d2, d3) of separation of the mobile device with respect to the satellites (5a, 5b, 5c) of the constellation, - on the basis of the pseudo-distance measurement carried out at the initial time t 0, in determining a first item of absolute position information of the mobile device at the initial time t 0, - starting with the absolute position information at the initial time and for each measurement carried out at the successive times t i in determining successive items of information on the position variation of the said mobile device between two consecutive measurement times t i and t i +Tv, - in encoding and transmitting the absolute position information and the successive items of position variation information to the position server. - starting from an initial time t 0 and at successive times t i greater than t 0 and spaced by a period Tv, in periodically measuring pseudo-distances (d1, d2, d3) of separation of the mobile device with respect to the satellites (5a, 5b, 5c) of the constellation, - on the basis of the pseudo-distance measurement carried out at the initial time t 0, in determining a first item of absolute position information of the mobile device at the initial time t 0, - starting with the absolute position information at the initial time and for each measurement carried out at the successive times t i in determining successive items of information on the position variation of the said mobile device between two consecutive measurement times t i and t i +Tv, - in encoding and transmitting the absolute position information and the successive items of position variation information to the position server.
Fluid damper for adjustable bodies with a piston adjustable in a cylinder, whereby in the piston and/or between piston and cylinder at least a passage (4.2) for flowing fluid It is trained that the piston is connected to a piston rod led out of the cylinder, whereby the passage opening comprises adjusting means to adjust a limitation at least the largest possible flow cross-section of the fluid at least at a passage opening (4.2) at the operating fluid damper wherein the adjusting means have an locking device which holds the piston in a desired location in the cylinder, wherein - the locking device on the end of the piston rod in the cylinder is indispensable in a radial manner - the undistocracy of the locking device compared to the piston rod is caused by a friction closure, which can be overcome when the locking device interfaces in a locking manner with a part of the cylinder - a locking element in the form of a sleeve which can be mounted on the end (6.1) of the piston rod and whose end facing the closed end of the cylinder carries an externally toothed gear (2.1) and at the other end at least one cam (2.2) engaging in the piston, - an internal toothed gear (1.1) arranged on the inside of the cylinder, into which the external toothed gear (2.1) intervenes, and - a central cone (1.2) arranged on the inside of the cylinder, which presses the teeth of the external toothed gear apart into the interior toothed gear (1.1). - the locking device on the end of the piston rod in the cylinder is indispensable in a radial manner - the undistocracy of the locking device compared to the piston rod is caused by a friction closure, which can be overcome when the locking device interfaces in a locking manner with a part of the cylinder - a locking element in the form of a sleeve which can be mounted on the end (6.1) of the piston rod and whose end facing the closed end of the cylinder carries an externally toothed gear (2.1) and at the other end at least one cam (2.2) engaging in the piston, - an internal toothed gear (1.1) arranged on the inside of the cylinder, into which the external toothed gear (2.1) intervenes, and - a central cone (1.2) arranged on the inside of the cylinder, which presses the teeth of the external toothed gear apart into the interior toothed gear (1.1).
Method for producing a cross-linked moulded body made of UHMWPE, comprising the steps: - providing a moulded body made of UHMWPE to which an antioxidant has been added; - heating the moulded body to a temperature of 100 °C or more; and - irradiating the moulded body to cross-link the UHMWPE in the moulded body, characterized in that the irradiation of the moulded body is done with X-rays. - providing a moulded body made of UHMWPE to which an antioxidant has been added; - heating the moulded body to a temperature of 100 °C or more; and - irradiating the moulded body to cross-link the UHMWPE in the moulded body,
Printhead for applying a coating agent to a component, in particular for painting a motor vehicle body component with a paint, with a) several nozzles for dispensing said coating agent, b) several control valves (23.1-23.4) which are associated with the individual nozzles and control the release of coating agent through the individual nozzles, c) a coating agent supply (4; 24) for supplying the coating agent to be applied and/or for supplying a rinsing agent, wherein the printhead enables a colour change during coating operation and can be rinsed with the rinsing agent during a colour change in order to rinse our coating agent residues from the printhead, characterized by d) a return system with a separate return connection for recirculating the coating agent and/or the rinsing agent. a) several nozzles for dispensing said coating agent, b) several control valves (23.1-23.4) which are associated with the individual nozzles and control the release of coating agent through the individual nozzles, c) a coating agent supply (4; 24) for supplying the coating agent to be applied and/or for supplying a rinsing agent, wherein the printhead enables a colour change during coating operation and can be rinsed with the rinsing agent during a colour change in order to rinse our coating agent residues from the printhead, characterized by d) a return system with a separate return connection for recirculating the coating agent and/or the rinsing agent.
Blank for producing a dosing device by folding made from a single piece of material characterized in that the single piece of material is essentially rectangular, recyclable, and without incisions or notches, wherein the blank comprises - a folding line extending essentially from the middle of one shorter side of the rectangular recyclable material in parallel to the longer sides of the rectangular recyclable material to a star point located in the middle between the longer sides of the rectangular recyclable material, - two folding lines and, each one extending from the star point to one of two corners of the rectangular recyclable material that are closest to the star point so that each one of the two corners is connected to the star point by one of the folding lines or, and - two folding lines and, each one extending from the star point in an angle (α) to one of two longer sides of the rectangular recyclable material so that folding line is extending to the longer side connected to the corner of the rectangular recyclable material that folding line is connected to and folding line is extending to the longer side connected to the corner of the rectangular recyclable material that folding line is connected to and the angle (α) between the folding lines and or and, respectively is smaller than the angle (β) between the folding lines and and and, respectively. - a folding line extending essentially from the middle of one shorter side of the rectangular recyclable material in parallel to the longer sides of the rectangular recyclable material to a star point located in the middle between the longer sides of the rectangular recyclable material, - two folding lines and, each one extending from the star point to one of two corners of the rectangular recyclable material that are closest to the star point so that each one of the two corners is connected to the star point by one of the folding lines or, and - two folding lines and, each one extending from the star point in an angle (α) to one of two longer sides of the rectangular recyclable material so that folding line is extending to the longer side connected to the corner of the rectangular recyclable material that folding line is connected to and folding line is extending to the longer side connected to the corner of the rectangular recyclable material that folding line is connected to and the angle (α) between the folding lines and or and, respectively is smaller than the angle (β) between the folding lines and and and, respectively.
Resin line with circumferential-side openings and an enveloping made of flow aid material, in which the flow aid material is placed around the resin line such that the tabs of the flow aid material projecting over the resin line form a double-layer web in the region of which the tabs are connected to one another and adjoining the web at the end facing away from the resin line is a section angled for such purpose, characterised in that one or both tabs in a section adjoining the web are placed in one or two loops which form the angled section/s.
Arrangement for transmitting data in a home or building installation system having at least one installation device which is in the form of a flush-mounted or surface-mounted device and is in the form of a socket, a switch, a pushbutton, a dimmer, a smoke detector, a motion detector, a building automation device with operating units for sun protection apparatuses, door communication systems, security systems and heating and air-conditioning systems, wherein the at least one installation device is equipped with at least one light source which acts as an optical transmission unit and wirelessly communicates with at least one receiver unit arranged at a distance from the transmission unit of the installation device and integrated in a mobile device by means of the light beams emitted by the transmission unit, wherein the light source is modified in such a manner that data can be transmitted using the visible light beams emitted by the light source of the installation device, characterized in that the data transmission comprises an identification marker of the device, an indication of the activation state and a status display, and the lighting element of an installation device, which operates as a transmission and/or reception unit, receives, evaluates and/or processes signals from the lighting element of a respectively adjacent installation device, which operates as a transmission and/or reception unit, via the receiver unit of the mobile device and vice versa.
A sensing system comprising: one or a plurality of wireless sensor nodes installable on a train, each wireless sensor node including a sensor, a measurement circuit and an independent power supply system and being configured to perform measurements based on a parameter value group that is one or a plurality of parameter values including setting values of the measurement circuit of the one or the plurality of wireless sensor nodes; and a sensing control device configured to specify a position of the train, determine, for at least one wireless sensor node among the one or the plurality of wireless sensor nodes, a parameter value group of the wireless sensor node corresponding to the specified position, and perform control to set the determined parameter value group in the wireless sensor node. one or a plurality of wireless sensor nodes installable on a train, each wireless sensor node including a sensor, a measurement circuit and an independent power supply system and being configured to perform measurements based on a parameter value group that is one or a plurality of parameter values including setting values of the measurement circuit of the one or the plurality of wireless sensor nodes; and a sensing control device configured to specify a position of the train, determine, for at least one wireless sensor node among the one or the plurality of wireless sensor nodes, a parameter value group of the wireless sensor node corresponding to the specified position, and perform control to set the determined parameter value group in the wireless sensor node.
A nestable trolley with a wheel frame and with a basket, wherein the wheel frame is equipped with two supports, and wherein a push handle is arranged on the supports, and wherein further the supports can be attached to the wheel frame using a connecting element, wherein a connecting element is arranged between each support and the wheel frame, characterised in that one part of the connecting element is introduced into a tube of the support and the second part is introduced into a tube of the wheel frame, in that the connecting element has two stabilising parts, in that one mount in each case is provided on the front side and rear side of the connecting element, and in that the cross-section of the connecting element is oval.
A modifier for polyolefin resin containing a copolymer having a polyolefin, an unsaturated dicarboxylic acid (anhydride) and an unsaturated aliphatic hydrocarbon as a constitutional unit and having an acid value of 50 to 250 mg KOH/g, wherein is a linear α-olefin or a branched α-olefin having a carbon number of 6 to 36, wherein is a graft copolymer having as a backbone and a (co)polymer of and as its side chain.