An amperometric analyte sensor system comprising: a probe platform; a first probe releasably coupled to and disposed on the probe platform and adapted to be inserted in vivo, wherein the first probe comprises: a first electrode array comprising a working electrode, a counter electrode and a reference electrode; and a second electrode array comprising a working electrode, a counter electrode and a reference electrode; a second probe releasably coupled to and disposed on the probe platform and adapted to be inserted in vivo, wherein the second probe comprises: a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode; wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another; a processor; a computer-readable program code having instructions, which when executed cause the processor to: assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability parameters; rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against the one or more reliability parameters; and compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and fourth electrode arrays. a probe platform; a first probe releasably coupled to and disposed on the probe platform and adapted to be inserted in vivo, wherein the first probe comprises: a first electrode array comprising a working electrode, a counter electrode and a reference electrode; and a second electrode array comprising a working electrode, a counter electrode and a reference electrode; a second probe releasably coupled to and disposed on the probe platform and adapted to be inserted in vivo, wherein the second probe comprises: a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode; wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another; a processor; a computer-readable program code having instructions, which when executed cause the processor to: assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability parameters; rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against the one or more reliability parameters; and compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and fourth electrode arrays. a first electrode array comprising a working electrode, a counter electrode and a reference electrode; and a second electrode array comprising a working electrode, a counter electrode and a reference electrode; a second probe releasably coupled to and disposed on the probe platform and adapted to be inserted in vivo, wherein the second probe comprises: a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode; wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another; a processor; a computer-readable program code having instructions, which when executed cause the processor to: assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability parameters; rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against the one or more reliability parameters; and compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and fourth electrode arrays. a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode; wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another; a processor; a computer-readable program code having instructions, which when executed cause the processor to: assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability parameters; rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against the one or more reliability parameters; and compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and fourth electrode arrays. assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability parameters; rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against the one or more reliability parameters; and compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and fourth electrode arrays.