mhurhangee/ep-ind-claims huggingface dataset:
A method of in vivo mutagenesis of a preselected target region of an intracellular DNA within a cell culture, which PTR comprises at least one sequence of interest which is at least 250 nucleobases long, the method comprising: a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which are non-complementary in their overlaps and which align to a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing single stranded oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant cells covering point mutations in said PTR at every position and combinations of said point mutations within said PTR, wherein the cell library comprises at least 10 6 library members which are characterized by different mutations. a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which are non-complementary in their overlaps and which align to a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing single stranded oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant cells covering point mutations in said PTR at every position and combinations of said point mutations within said PTR, wherein the cell library comprises at least 10 6 library members which are characterized by different mutations.
A processor-based method for characterizing an aspect of a tissue structure present in an ultrasound image, said method comprising: analyzing said image to identify said aspect of said tissue structure; normalizing intensity information of said image wherein said normalising comprises applying an adjustment factor that is dependent on known densities of one or more landmarks in said image that have a relatively consistent density from patient to patient; determining density information for said aspect using said normalized intensity information; and characterizing said aspect using said density information. analyzing said image to identify said aspect of said tissue structure; normalizing intensity information of said image wherein said normalising comprises applying an adjustment factor that is dependent on known densities of one or more landmarks in said image that have a relatively consistent density from patient to patient; determining density information for said aspect using said normalized intensity information; and characterizing said aspect using said density information.
A positive-type photosensitive resin composition consisting of a (a) polybenzoxazole precursor, a (b) crosslinking agent, a (c) photosensitive agent, and a (d) solvent, wherein the (a) component comprises a structural unit represented by Formula below, and the (b) component is a compound represented by Formula below: wherein, in Formula, U is a bivalent organic group, a single bond, -O-, or -SO 2 -, V is a group comprising an aliphatic structure, and the carbon number in the aliphatic structure is 1 to 30; wherein, in Formula, R 1 is independently a hydrogen atom or a group represented by -CH 2 -O-R 2, at least one of the plurality of R 1 s is a group represented by -CH 2 -O-R 2, and R 2 is independently a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.
An apparatus for generating pressure pulses in a drilling fluid flowing and enhancing completing a well bore within a coiled tubing assembly comprising: a flow throttling device longitudinally and axially positioned within the center of a main valve actuator assembly, said main valve actuator assembly comprising a main valve pressure chamber, a magnetic pressure cup encompassing a rotary magnetic coupling containing at least one magnet adjacent to a drive shaft wherein said magnetic pressure cup is located within a pilot actuator assembly, said pilot actuator assembly including a pilot orifice with a pilot valve, a pilot flowshield, a bellows and an anti-rotation block such that said drilling fluid flows through a pilot flowscreens and further flows into a main flow entrance into a flow cone through a main orifice and into a main valve past said main valve pressure chamber past a set of seals and through a main valve support block toward a flow seal guide where said fluid combines with a pilot exit fluid that flows toward a main exit flow such that as said fluid becomes a pilot fluid, said pilot fluid subsequently flows through said pilot flow screen into said pilot flow screen chamber through a pilot flow upper annulus, through a pilot flow lower annulus and into a pilot flow inlet channel, wherein said pilot fluid then flows up into said main valve feed channel until it reaches said main valve pressure chamber such that said pilot fluid flows back down said main valve feed channel through said pilot flow exit channel through said pilot orifice and said pilot valve such that said pilot fluid exits said pilot valve and said pilot fluid then flows over a pilot flow shield such that said pilot fluid combines with said main flow to become the main exit flowfluid, said main exit flow fluid then exits a pilot valve support block and flows on either side of said magnetic pressure cup including said rotary magnetic coupling and wherein one or more pressure sensors measuring the pressure of flowing fluid is located inside said pilot valve support block upon which a helical pulser support rests wherein said pilot valve support block also houses an annular pressure sensor residing in an annular pressure inlet and wherein a lower portion of said pilot valve support block also contains a helically cut cylinder that mates with and rests on a helical pulser support that is mounted securely in a tubular hang-off collar such that said annular pressure inlet is aligned with one or more collared annular pressure ports thus still allowing said main exit flowfluid to flow past a drive shaft and motor such that said pilot fluid and main exit flowfluid causes one or more flow throttling devices to generate large, rapid controllable pulses thereby allowing transmission of well developed signals easily distinguished from any noise resulting from other vibrations due to nearby equipment within a borehole or exterior to said borehole, or within said coiled tubing assembly, wherein said signals also are capable of providing predetermined height, width and shape.
A method for generating stem-cell derived β (SC-β) cells, the method comprising contacting a cell population comprising endocrine progenitor cells under conditions suitable to direct differentiation of said endocrine progenitor cells into said SC-β cells with an effective amount of an agent that decreases activity of c-Jun N-terminal kinase in said endocrine progenitor cells, thereby generating said SC-β cells, wherein the endocrine progenitor cells comprise PDX1+/NKX6.1+/NEUROD1+/insulin+/glucagon-/somatostatin-cells, wherein the effective amount comprises a concentration between about 0.1 μM and about 110 μM, wherein the agent is SP600125.
An agricultural baler comprising a baling chamber and a pre-compression chamber, wherein the pre-compression chamber is adapted to gather crop material and to periodically form a slice of said crop material and push the slice towards the baling chamber into a first segment of the baling chamber, the baling chamber comprising a plunger provided for reciprocally moving in the baling chamber thereby compressing slices of crop material into a bale, characterised in that a slice-presence-detecting sensor is provided in an upper region of said first segment, an output of said sensor being operationally connected to a controller which is adapted to adjust a synchronization between the periodically forming and pushing of the slice in the pre-compression chamber and the reciprocal movement of the plunger.
A system for allowing controlled access of a tool to all sides of an elevated tissue in a body of a patient, the system comprising: a rail configured to surround the elevated tissue; at least one vehicle configured to move along the rail and carry at least one tool that is configured to manipulate the elevated tissue, wherein the tool is a cutting tool comprising a blade configured to cut the elevated tissue, characterized in that a tissue remover is attached to an upper part of the at least one tool or of the at least one vehicle, said tissue remover having a substantially flat structure and being attached substantially diagonally above the cutting tool or vehicle. a rail configured to surround the elevated tissue; at least one vehicle configured to move along the rail and carry at least one tool that is configured to manipulate the elevated tissue, wherein the tool is a cutting tool comprising a blade configured to cut the elevated tissue, characterized in that a tissue remover is attached to an upper part of the at least one tool or of the at least one vehicle, said tissue remover having a substantially flat structure and being attached substantially diagonally above the cutting tool or vehicle.
A roofing underlayment having opposite sides, the roofing underlayment comprising: a synthetic roofing underlayment on one side; a reflective layer on the other side, the reflective layer comprising a reflective outer surface on the other side of the roofing underlayment, the reflective outer surface being the only reflective outer surface of the roofing underlayment; and an insulation layer between the synthetic roofing underlayment and the reflective layer, the insulation layer being fiberglass insulation. a synthetic roofing underlayment on one side; a reflective layer on the other side, the reflective layer comprising a reflective outer surface on the other side of the roofing underlayment, the reflective outer surface being the only reflective outer surface of the roofing underlayment; and an insulation layer between the synthetic roofing underlayment and the reflective layer, the insulation layer being fiberglass insulation.
An inductive measuring assembly for coin testing in free-fall coin devices, in which at least one elongate coil arrangement extends transversely to the fall path on one side of the fall path of the coins, wherein two walls (10, 12) limit the fall path, characterized in that two coaxial elongate coils comprising a first inner coil and a second outer coil are arranged side by side, wherein the first inner coil is located closer to the walls (10, 12) than the second outer coil, and a shell core E-shaped in cross-section is provided, receiving the coils between its outer legs, wherein its middle leg extends through the first inner coil and not or only partially into the second outer coil.
A turning angle detecting device comprising: a position detecting unit configured to detect a turning angle (θt) of a wheel turning mechanism; an actuator configured to drive the wheel turning mechanism; a first storage unit configured to store a turning angle neutral point correction value (Δθt) being a difference between a median of the turning angles at respective limits in right steering and left steering and the turning angle when a vehicle is traveling straight; a second storage unit configured to store an actuator initial position (θm0) being a position of a movable portion of the actuator when the vehicle is traveling straight; an actuator position detecting unit configured to detect the position of the movable portion of the actuator as a first actuator position; a first turning angle calculating unit configured to calculate, as a first turning angle (θt1), the turning angle of the wheel turning mechanism with respect to the median of the turning angles at the respective limits in the right steering and the left steering on a basis of the first actuator position; and a second turning angle calculating unit configured to calculate a second turning angle (θt2) with respect to the turning angle of the wheel turning mechanism when the vehicle is traveling straight on a basis of the first actuator position (θm), the turning angle neutral point correction value (Δθt), the actuator initial position (θm0), and the first turning angle (θt1). a position detecting unit configured to detect a turning angle (θt) of a wheel turning mechanism; an actuator configured to drive the wheel turning mechanism; a first storage unit configured to store a turning angle neutral point correction value (Δθt) being a difference between a median of the turning angles at respective limits in right steering and left steering and the turning angle when a vehicle is traveling straight; a second storage unit configured to store an actuator initial position (θm0) being a position of a movable portion of the actuator when the vehicle is traveling straight; an actuator position detecting unit configured to detect the position of the movable portion of the actuator as a first actuator position; a first turning angle calculating unit configured to calculate, as a first turning angle (θt1), the turning angle of the wheel turning mechanism with respect to the median of the turning angles at the respective limits in the right steering and the left steering on a basis of the first actuator position; and a second turning angle calculating unit configured to calculate a second turning angle (θt2) with respect to the turning angle of the wheel turning mechanism when the vehicle is traveling straight on a basis of the first actuator position (θm), the turning angle neutral point correction value (Δθt), the actuator initial position (θm0), and the first turning angle (θt1).
Method for processing a sheet of a flexible material moving along a material movement direction, in which individual sections are produced from the material sheet by means of a first double slide linear motor and a second double slide linear motor which are arranged parallel to the material movement direction and each have a first slide (14, 16) and a second slide (18, 20) in the material movement direction, each having a tappet, - wherein, by means of the tappet of the first slide of the first double slide linear motor, a region of the sheet corresponding to the length of the section is pulled along the material movement direction, - wherein the region is transferred to the tappet of the second slide of the second double slide linear motor, - wherein the region is separated from the material sheet by means of a cutting tool, in particular by means of the first slide of the second double slide linear motor, - wherein the separated region is taken away by means of the tappet of the second slide of the second double slide linear motor, and - wherein this is gripped in the movement direction behind the region by means of the tappet of the first slide of the second double slide linear motor temporally before the separation of the region from the material sheet. - wherein, by means of the tappet of the first slide of the first double slide linear motor, a region of the sheet corresponding to the length of the section is pulled along the material movement direction, - wherein the region is transferred to the tappet of the second slide of the second double slide linear motor, - wherein the region is separated from the material sheet by means of a cutting tool, in particular by means of the first slide of the second double slide linear motor, - wherein the separated region is taken away by means of the tappet of the second slide of the second double slide linear motor, and - wherein this is gripped in the movement direction behind the region by means of the tappet of the first slide of the second double slide linear motor temporally before the separation of the region from the material sheet.
A method of forming a multilayer electroless metal coating on a substrate, the method comprising: i. contacting the substrate with a first electroless nickel plating bath to form a first eletroless nickel coating on the substrate, the first electroless nickel coating having a phosphorus content of 7% to 13% by weight ii. contacting the substrate coated with the first electroless coating with a second aqueous electroless nickel plating bath to form a second electroless nickel coating over the first electroless coating, the second electroless coating having a phosphorous content of 8% to 11%, the second bath including nickel, a hypophosphorous reducing agent, 40 ppm to 100 ppm zinc, at least one of a complexing agent, chelating agent, and/or pH buffer, and 5 ppm to 30 ppm bismuth stabilizer, wherein the bath is free of an organic sulfur compound; iii. etching the second electroless nickel coating with an etchant agent to provide the coated substrate with a black surface or contacting the substrate coated with the first and second electroless nickel coatings with an electroless copper plating bath to provide a copper top coat. i. contacting the substrate with a first electroless nickel plating bath to form a first eletroless nickel coating on the substrate, the first electroless nickel coating having a phosphorus content of 7% to 13% by weight ii. contacting the substrate coated with the first electroless coating with a second aqueous electroless nickel plating bath to form a second electroless nickel coating over the first electroless coating, the second electroless coating having a phosphorous content of 8% to 11%, the second bath including nickel, a hypophosphorous reducing agent, 40 ppm to 100 ppm zinc, at least one of a complexing agent, chelating agent, and/or pH buffer, and 5 ppm to 30 ppm bismuth stabilizer, wherein the bath is free of an organic sulfur compound; iii. etching the second electroless nickel coating with an etchant agent to provide the coated substrate with a black surface or contacting the substrate coated with the first and second electroless nickel coatings with an electroless copper plating bath to provide a copper top coat.
An optically triggered photonic power switch comprising an avalanche photo diode and a switch element, characterized in that the switch element comprises a carrier donor layer and a channel layer, wherein the avalanche photo diode is disposed on the switch element and comprises an absorption layer configured to generate by photoeffect, accelerated charge carriers; and wherein the switch element is configured to generate a conduction layer between the carrier donor layer and the channel layer, such that said accelerated charge carriers travel from the avalanche photo diode into the carrier donor layer and modulate a two dimensional electron gas built in said conduction layer.
Thermoreversible hydrogel including (a) a chain-extended poloxamer P* prepared by reacting at least one poloxamer P with a diisocyanate, each poloxamer comprising two poly(oxyethylene) blocks PEG and one poly(oxypropylene) block PPG and the molecular weight of the poly(oxypropylene) block of P being greater than 2350 Da, with the proviso that at a molecular weight Mw of the poloxamer P of 11,000 or more and a proportion of polyethylene oxide in P exceeding 60%, at least two different poloxamers are reacted, and (b) a biological material, selected from the group consisting of an antibiotic, antimicrobial or antimycotic active substance, proteins, glucosaminoglycans, lysozyme and a natural or synthetic polyamino acid. (a) a chain-extended poloxamer P* prepared by reacting at least one poloxamer P with a diisocyanate, each poloxamer comprising two poly(oxyethylene) blocks PEG and one poly(oxypropylene) block PPG and the molecular weight of the poly(oxypropylene) block of P being greater than 2350 Da, with the proviso that at a molecular weight Mw of the poloxamer P of 11,000 or more and a proportion of polyethylene oxide in P exceeding 60%, at least two different poloxamers are reacted, and (b) a biological material, selected from the group consisting of an antibiotic, antimicrobial or antimycotic active substance, proteins, glucosaminoglycans, lysozyme and a natural or synthetic polyamino acid.
A polyamide-imide resin, which is an imide of a polyamic acid resulting from copolymerizing an aromatic dianhydride and an aromatic dicarbonyl compound with an aromatic diamine, wherein the aromatic dicarbonyl compound is contained in an amount of 1 to 50 mol% based on a total molar amount of the aromatic dianhydride and the aromatic dicarbonyl compound, the aromatic dianhydride includes (i) 4,4'-hexafluoroisopropylidene diphthalic anhydride and (ii) at least one selected from among cyclobutanetetracarboxylic dianhydride (CBDA) and cyclopentanetetracarboxylic dianhydride (CPDA), and the aromatic diamine includes 2,2'-bis(trifluoromethyl)-1,1'-biphenyl-4,4'-diamine (TFDB).
A titanium oxide composite fiber, comprising: - fiber; - titanium oxide; and - an inorganic binder, at least part of the inorganic binder containing at least one inorganic compound selected from (i) an inorganic salt containing at least one of: - at least one metal selected from magnesium, barium, aluminum, copper, iron, and zinc; and - silicic acid and (ii) metal particles containing the at least one metal, the inorganic binder being firmly fixed to the fiber, the titanium oxide being firmly fixed to the inorganic binder so that the titanium oxide is firmly fixed to the fiber via the inorganic binder, and the fiber having a surface not less than 15% of which is covered with the inorganic binder. - fiber; - titanium oxide; and - an inorganic binder, at least part of the inorganic binder containing at least one inorganic compound selected from (i) an inorganic salt containing at least one of: - at least one metal selected from magnesium, barium, aluminum, copper, iron, and zinc; and - silicic acid and (ii) metal particles containing the at least one metal, the inorganic binder being firmly fixed to the fiber, the titanium oxide being firmly fixed to the inorganic binder so that the titanium oxide is firmly fixed to the fiber via the inorganic binder, and the fiber having a surface not less than 15% of which is covered with the inorganic binder. (i) an inorganic salt containing at least one of: - at least one metal selected from magnesium, barium, aluminum, copper, iron, and zinc; and - silicic acid and - at least one metal selected from magnesium, barium, aluminum, copper, iron, and zinc; and - silicic acid and (ii) metal particles containing the at least one metal, the inorganic binder being firmly fixed to the fiber, the titanium oxide being firmly fixed to the inorganic binder so that the titanium oxide is firmly fixed to the fiber via the inorganic binder, and the fiber having a surface not less than 15% of which is covered with the inorganic binder. the inorganic binder being firmly fixed to the fiber, the titanium oxide being firmly fixed to the inorganic binder so that the titanium oxide is firmly fixed to the fiber via the inorganic binder, and the fiber having a surface not less than 15% of which is covered with the inorganic binder.