System for determining a tissue type of a tissue region of a tissue; the system comprising an optical probe, a spectral measurement system and a processing unit; wherein the optical probe comprises a distal end (OPDE) and at least three optical fibers (OF 1..n), each optical fiber having a distal end (OFDE 1..n) disposed at the distal end of the optical probe (OPDE) and a proximal end (OFPE 1..n) that is in optical communication with the spectral measurement system; wherein the spectral measurement system comprises at least one optical source and at least one optical detector; wherein each proximal end of each optical fiber (OFPE 1..n) is in optical communication with one of the at least one optical source or one of the at least one optical detector, and wherein each distal end of each optical fiber (OFDE 1..n) is arranged at the distal end of the optical probe (OPDE) such that when the tissue region is in contact with the distal end of the optical probe (OPDE) a plurality of intersecting optical paths (IOP 1..k) are defined within the tissue region between the at least one optical source and the at least one optical detector; wherein the processing unit is in communication with the spectral measurement system and is configured to cause the spectral measurement system to generate spectral measurement data corresponding to each of the plurality of intersecting optical paths (IOP 1..k), and to generate from said spectral measurement data a tissue signal (Q 1..k) indicative of a tissue type for the respective optical path; wherein the processing unit is further configured to: compare each tissue signal (Q 1..k) with a reference threshold for the tissue type; and to compare each tissue signal (Q 1..k) with an average of the tissue signals (Q 1..k); and to identify at least a portion of the tissue region as the tissue type if i) every tissue signal (Q 1..k) in the tissue region indicates that its corresponding tissue is not the tissue type in the comparison with the reference threshold and ii) at least one of the tissue signals (Q 1..k) in the tissue region lies between the average of the tissue signals (Q 1..k) and the reference threshold, and a difference (Δ) between the at least one tissue signal (Q 1..k) and the average of the tissue signals (Q 1..k) exceeds a predetermined value (ΔP). wherein the optical probe comprises a distal end (OPDE) and at least three optical fibers (OF 1..n), each optical fiber having a distal end (OFDE 1..n) disposed at the distal end of the optical probe (OPDE) and a proximal end (OFPE 1..n) that is in optical communication with the spectral measurement system; wherein the spectral measurement system comprises at least one optical source and at least one optical detector; wherein each proximal end of each optical fiber (OFPE 1..n) is in optical communication with one of the at least one optical source or one of the at least one optical detector, and wherein each distal end of each optical fiber (OFDE 1..n) is arranged at the distal end of the optical probe (OPDE) such that when the tissue region is in contact with the distal end of the optical probe (OPDE) a plurality of intersecting optical paths (IOP 1..k) are defined within the tissue region between the at least one optical source and the at least one optical detector; wherein the processing unit is in communication with the spectral measurement system and is configured to cause the spectral measurement system to generate spectral measurement data corresponding to each of the plurality of intersecting optical paths (IOP 1..k), and to generate from said spectral measurement data a tissue signal (Q 1..k) indicative of a tissue type for the respective optical path; wherein the processing unit is further configured to: compare each tissue signal (Q 1..k) with a reference threshold for the tissue type; and to compare each tissue signal (Q 1..k) with an average of the tissue signals (Q 1..k); and to identify at least a portion of the tissue region as the tissue type if i) every tissue signal (Q 1..k) in the tissue region indicates that its corresponding tissue is not the tissue type in the comparison with the reference threshold and ii) at least one of the tissue signals (Q 1..k) in the tissue region lies between the average of the tissue signals (Q 1..k) and the reference threshold, and a difference (Δ) between the at least one tissue signal (Q 1..k) and the average of the tissue signals (Q 1..k) exceeds a predetermined value (ΔP). compare each tissue signal (Q 1..k) with a reference threshold for the tissue type; and to compare each tissue signal (Q 1..k) with an average of the tissue signals (Q 1..k); and to identify at least a portion of the tissue region as the tissue type if i) every tissue signal (Q 1..k) in the tissue region indicates that its corresponding tissue is not the tissue type in the comparison with the reference threshold and ii) at least one of the tissue signals (Q 1..k) in the tissue region lies between the average of the tissue signals (Q 1..k) and the reference threshold, and a difference (Δ) between the at least one tissue signal (Q 1..k) and the average of the tissue signals (Q 1..k) exceeds a predetermined value (ΔP).