A compound of Formula: or a pharmaceutically acceptable salt thereof; wherein: ------ represents a single or a double bond; Z is O or S; X is O, CR 5, CR 5 OH, or C(R 5) 2, wherein: when X is O, ------ is a single bond; when X is C(R 5) 2' ------ is a single bond; when X is CR 5 OH, ------ is a single bond; or when X is CR 5, ------ is a double bond; R 1 is aryl, heteroaryl, L-cycloalkyl, -N(R 5)heterocyclyl, or L-heterocyclyl, wherein the aryl, the heteroaryl or the cyclyl portion of the L-cycloalkyl, N(R 5)heterocyclyl, or L-heterocyclyl is optionally substituted with one or more R 4; R 2 is cyano, -COOR 5, or -C N(R 5) 2; or R 2 is -C N(R 5a) 2 wherein each R 5a taken together with the nitrogen atom to which they are attached form a 5-8 membered heterocyclic ring optionally substituted with one or more R 4; each R 3 is independently C1 - C3 alkyl or halogen; each R 4 is independently oxo, cyano, halogen, -PO 3 (C1 - C3 alkyl) 2, alkoxy, hydroxyalkyl, heteroalkyl, aralkyl, haloalkyl, -COOR 5, -Y 2 -haloalkyl, -Y 1 -C1 - C6 alkyl, -Y 2 -C1 - C6 alkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl, -Y 1 -heterocyclyl, -Y 2 -heterocyclyl, -L-N(R 5) 2, -O-L-N(R 5) 2, -C(CF 3)N(R 5) 2, -Y 1 -N(R 5) 2, or -Y 2 -N(R 5) 2 wherein the ring portion of the aralkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl or -Y 1 -heterocyclyl is optionally substituted with one or more R 7; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or-NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1 or 2. ------ represents a single or a double bond; Z is O or S; X is O, CR 5, CR 5 OH, or C(R 5) 2, wherein: when X is O, ------ is a single bond; when X is C(R 5) 2' ------ is a single bond; when X is CR 5 OH, ------ is a single bond; or when X is CR 5, ------ is a double bond; R 1 is aryl, heteroaryl, L-cycloalkyl, -N(R 5)heterocyclyl, or L-heterocyclyl, wherein the aryl, the heteroaryl or the cyclyl portion of the L-cycloalkyl, N(R 5)heterocyclyl, or L-heterocyclyl is optionally substituted with one or more R 4; R 2 is cyano, -COOR 5, or -C N(R 5) 2; or R 2 is -C N(R 5a) 2 wherein each R 5a taken together with the nitrogen atom to which they are attached form a 5-8 membered heterocyclic ring optionally substituted with one or more R 4; each R 3 is independently C1 - C3 alkyl or halogen; each R 4 is independently oxo, cyano, halogen, -PO 3 (C1 - C3 alkyl) 2, alkoxy, hydroxyalkyl, heteroalkyl, aralkyl, haloalkyl, -COOR 5, -Y 2 -haloalkyl, -Y 1 -C1 - C6 alkyl, -Y 2 -C1 - C6 alkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl, -Y 1 -heterocyclyl, -Y 2 -heterocyclyl, -L-N(R 5) 2, -O-L-N(R 5) 2, -C(CF 3)N(R 5) 2, -Y 1 -N(R 5) 2, or -Y 2 -N(R 5) 2 wherein the ring portion of the aralkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl or -Y 1 -heterocyclyl is optionally substituted with one or more R 7; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or-NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1 or 2. when X is O, ------ is a single bond; when X is C(R 5) 2' ------ is a single bond; when X is CR 5 OH, ------ is a single bond; or when X is CR 5, ------ is a double bond; R 1 is aryl, heteroaryl, L-cycloalkyl, -N(R 5)heterocyclyl, or L-heterocyclyl, wherein the aryl, the heteroaryl or the cyclyl portion of the L-cycloalkyl, N(R 5)heterocyclyl, or L-heterocyclyl is optionally substituted with one or more R 4; R 2 is cyano, -COOR 5, or -C N(R 5) 2; or R 2 is -C N(R 5a) 2 wherein each R 5a taken together with the nitrogen atom to which they are attached form a 5-8 membered heterocyclic ring optionally substituted with one or more R 4; each R 3 is independently C1 - C3 alkyl or halogen; each R 4 is independently oxo, cyano, halogen, -PO 3 (C1 - C3 alkyl) 2, alkoxy, hydroxyalkyl, heteroalkyl, aralkyl, haloalkyl, -COOR 5, -Y 2 -haloalkyl, -Y 1 -C1 - C6 alkyl, -Y 2 -C1 - C6 alkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl, -Y 1 -heterocyclyl, -Y 2 -heterocyclyl, -L-N(R 5) 2, -O-L-N(R 5) 2, -C(CF 3)N(R 5) 2, -Y 1 -N(R 5) 2, or -Y 2 -N(R 5) 2 wherein the ring portion of the aralkyl, -L-cycloalkyl, -L-heteroaryl, -L-heterocyclyl or -Y 1 -heterocyclyl is optionally substituted with one or more R 7; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or-NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1 or 2.