Ocular iontophoresis device for delivering at least one active substance to an eyeball, comprising: - a reservoir configured for receiving at least one active substance (X 1, X 2), - a wall defining a tubular-shaped body arranged along a longitudinal axis, delimitating laterally the reservoir and comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding the cornea and a part of the sclera of the eyeball, - a first electrode configured to be positioned in front of the part of the sclera which is surrounded by the wall when the wall is in place on said ocular surface, said first electrode being configured for delivering a first current density (D 1) to at least one active substance of the reservoir, the device being characterized in that it further comprises: - a second electrode configured to be positioned in front of the cornea when the wall is in place on said ocular surface, said second electrode being configured for delivering a second current density (D 2) to at least one active substance of the reservoir, - at least one controller (17, 18) for independently controlling said first and second electrodes (15, 16), and in that: - the second electrode defines a disk-shaped second surface (S 2) extending perpendicularly to the longitudinal axis, the second surface (S 2) being arranged over a central part of the reservoir, the first electrode defining an annular-shaped first surface (S 1) extending perpendicularly to the longitudinal axis, the first surface (S 1) being arranged over a peripheral part of the reservoir, - first and second electrodes (15, 16) are arranged concentrically to each other, so that the first electrode and the second electrode are respectively positioned in front of the sclera and in front of the cornea, when the device is positioned on said ocular surface. - a reservoir configured for receiving at least one active substance (X 1, X 2), - a wall defining a tubular-shaped body arranged along a longitudinal axis, delimitating laterally the reservoir and comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding the cornea and a part of the sclera of the eyeball, - a first electrode configured to be positioned in front of the part of the sclera which is surrounded by the wall when the wall is in place on said ocular surface, said first electrode being configured for delivering a first current density (D 1) to at least one active substance of the reservoir, - a second electrode configured to be positioned in front of the cornea when the wall is in place on said ocular surface, said second electrode being configured for delivering a second current density (D 2) to at least one active substance of the reservoir, - at least one controller (17, 18) for independently controlling said first and second electrodes (15, 16), and in that: - the second electrode defines a disk-shaped second surface (S 2) extending perpendicularly to the longitudinal axis, the second surface (S 2) being arranged over a central part of the reservoir, the first electrode defining an annular-shaped first surface (S 1) extending perpendicularly to the longitudinal axis, the first surface (S 1) being arranged over a peripheral part of the reservoir, - first and second electrodes (15, 16) are arranged concentrically to each other, so that the first electrode and the second electrode are respectively positioned in front of the sclera and in front of the cornea, when the device is positioned on said ocular surface.