An implantable nerve stimulation system configured to deliver a stimulation therapy, the system comprising: a sensor configured to detect a respiration signal of the subject, the respiration signal defining a respiratory waveform of the subject; a stimulation electrode configured to deliver the stimulation therapy to a hypoglossal nerve of the subject; and a processor communicating with the sensor and the stimulation electrode, the processor configured to receive an input comprising the respiratory waveform and further configured to generate a therapy signal responsive to the input, the therapy signal comprising the stimulation therapy, the respiratory waveform including a plurality of respiratory cycles each corresponding to at least one of a breath and an attempted breath of the subject, the respiratory waveform further including a breathing pattern over a period of time, the breathing pattern comprising a repeating pattern of a plurality of respiratory cycles followed by at least one respiratory cycle corresponding to a disordered breathing event, the therapy signal including a series of stimulation pulses, the series of stimulation pulses being coordinated with the breathing pattern; wherein the breathing pattern includes a trend defined by a plurality of peak magnitudes of the plurality of respiratory cycles in combination with at least one of a plurality of minima magnitudes of the plurality of respiratory cycles, a plurality of expiration detections of the plurality of respiratory cycles, and a plurality of inspiration detections of the plurality of respiratory cycles; and wherein the processor, in order to generate the therapy signal, is configured to implement the steps of: detecting the respiratory waveform of the subject based on the respiratory signal; identifying the breathing pattern and the trend based on analyzing the respiratory waveform over the period of time; and identifying the disordered breathing event based on the trend exceeding, crossing and/or surpassing a threshold or based on the trend extrapolated to extend into a future projected time period where it is estimated that the trend exceeds, crosses and/or surpasses the threshold. a sensor configured to detect a respiration signal of the subject, the respiration signal defining a respiratory waveform of the subject; a stimulation electrode configured to deliver the stimulation therapy to a hypoglossal nerve of the subject; and a processor communicating with the sensor and the stimulation electrode, the processor configured to receive an input comprising the respiratory waveform and further configured to generate a therapy signal responsive to the input, the therapy signal comprising the stimulation therapy, the respiratory waveform including a plurality of respiratory cycles each corresponding to at least one of a breath and an attempted breath of the subject, the respiratory waveform further including a breathing pattern over a period of time, the breathing pattern comprising a repeating pattern of a plurality of respiratory cycles followed by at least one respiratory cycle corresponding to a disordered breathing event, the therapy signal including a series of stimulation pulses, the series of stimulation pulses being coordinated with the breathing pattern; wherein the breathing pattern includes a trend defined by a plurality of peak magnitudes of the plurality of respiratory cycles in combination with at least one of a plurality of minima magnitudes of the plurality of respiratory cycles, a plurality of expiration detections of the plurality of respiratory cycles, and a plurality of inspiration detections of the plurality of respiratory cycles; and wherein the processor, in order to generate the therapy signal, is configured to implement the steps of: detecting the respiratory waveform of the subject based on the respiratory signal; identifying the breathing pattern and the trend based on analyzing the respiratory waveform over the period of time; and identifying the disordered breathing event based on the trend exceeding, crossing and/or surpassing a threshold or based on the trend extrapolated to extend into a future projected time period where it is estimated that the trend exceeds, crosses and/or surpasses the threshold. detecting the respiratory waveform of the subject based on the respiratory signal; identifying the breathing pattern and the trend based on analyzing the respiratory waveform over the period of time; and identifying the disordered breathing event based on the trend exceeding, crossing and/or surpassing a threshold or based on the trend extrapolated to extend into a future projected time period where it is estimated that the trend exceeds, crosses and/or surpasses the threshold.