A compound of Formula I wherein: A is or X is CH, or N; Z is CH, or N, provided that X and Z are not both CH; J is N or CH; Q is C-R 5, provided that J is N, or Q is N, provided that J is CH; R 1 is H, phenyl, heteroaryl, CF 3, -CH=CH 2, CO 2 C alkyl, NHBOC, NHC alkyl, N(C alkyl)CO 2 CH 2 Ph, NR b C R bb, NR b SO 2 R bb " C N(CH 3)OCH 3, C NR b C alkyl, C NHCH 2 Ph(OCH 3) 2, -C (CH 2 CH=CH 2) 2, 3,6-dihydropyran-2-yl, 2,5-dihydrofuran-2-yl, tetrahydropyranyl, cyclopentenyl, cyclopentanyl, cyclohexenyl, cyclohexanyl, tetrahydrofuran-2-yl, cycloheptanyl, or or unsubstituted or substituted C alkyl wherein said alkyl may be substituted with up to two substituents wherein one substituent is selected from the group consisting of OH, C alkenyl, C cycloalkyl, NH 2, NHBOC, N(C alkyl) 2, NHSO 2 R b, NR b C R bb, NHCO 2 R b, NHCONR b R bb, OC alkyl, OC C alkyl, OC NR b R bb, CO 2 C alkyl, C NR b R bb, C alkylnyl, thiazolyl, oxazolyl, furyl, CF 3, CF 2 CF 2 CF 3, CH 2 NHCOC alkyl, N 3, SCH 3, S CH 3, SO 2 CH 3 and -CN, and the second substituent on the C alkyl is OH, and wherein said phenyl or heteroaryl is optionally substituted with one substituent selected from the group consisting of: OH, - CN, CH 2 OH, OC alkyl, NH 2, NHC alkyl, OC alkyl, C C alkyl, CO 2 C alkyl, C NHC alkyl, CO 2 NHC alkyl, SC alkyl, SOC alkyl, SO 2 C alkyl, SO 2 NHC alkyl, NHSO 2 C alkyl, NHCO 2 C alkyl, NHC C alkyl, NO 2, and C alkyl; R 2 is H, or OH; or R 1 and R 2 may together form a carbonyl; R 3 is H, C alkyl, -CN, CHF 2, or CF 3; R 4 is H or CH 3; R 5 is H or deuterium; R a is H, or CH 3; R b is H, C alkyl, or CF 3; R bb is H, C alkyl, or CF 3; and pharmaceutically acceptable salts thereof. A is or X is CH, or N; Z is CH, or N, provided that X and Z are not both CH; J is N or CH; Q is C-R 5, provided that J is N, or Q is N, provided that J is CH; R 1 is H, phenyl, heteroaryl, CF 3, -CH=CH 2, CO 2 C alkyl, NHBOC, NHC alkyl, N(C alkyl)CO 2 CH 2 Ph, NR b C R bb, NR b SO 2 R bb " C N(CH 3)OCH 3, C NR b C alkyl, C NHCH 2 Ph(OCH 3) 2, -C (CH 2 CH=CH 2) 2, 3,6-dihydropyran-2-yl, 2,5-dihydrofuran-2-yl, tetrahydropyranyl, cyclopentenyl, cyclopentanyl, cyclohexenyl, cyclohexanyl, tetrahydrofuran-2-yl, cycloheptanyl, or or unsubstituted or substituted C alkyl wherein said alkyl may be substituted with up to two substituents wherein one substituent is selected from the group consisting of OH, C alkenyl, C cycloalkyl, NH 2, NHBOC, N(C alkyl) 2, NHSO 2 R b, NR b C R bb, NHCO 2 R b, NHCONR b R bb, OC alkyl, OC C alkyl, OC NR b R bb, CO 2 C alkyl, C NR b R bb, C alkylnyl, thiazolyl, oxazolyl, furyl, CF 3, CF 2 CF 2 CF 3, CH 2 NHCOC alkyl, N 3, SCH 3, S CH 3, SO 2 CH 3 and -CN, and the second substituent on the C alkyl is OH, and wherein said phenyl or heteroaryl is optionally substituted with one substituent selected from the group consisting of: OH, - CN, CH 2 OH, OC alkyl, NH 2, NHC alkyl, OC alkyl, C C alkyl, CO 2 C alkyl, C NHC alkyl, CO 2 NHC alkyl, SC alkyl, SOC alkyl, SO 2 C alkyl, SO 2 NHC alkyl, NHSO 2 C alkyl, NHCO 2 C alkyl, NHC C alkyl, NO 2, and C alkyl; R 2 is H, or OH; or R 1 and R 2 may together form a carbonyl; R 3 is H, C alkyl, -CN, CHF 2, or CF 3; R 4 is H or CH 3; R 5 is H or deuterium; R a is H, or CH 3; R b is H, C alkyl, or CF 3; R bb is H, C alkyl, or CF 3;