A compound of formula or a pharmaceutically acceptable salt, or N-oxide thereof: Wherein: Y is selected from hydrogen, hydroxyl, -NH 2, -NH-C 1-4 -alkyl, -NH-halo-C 1-4 -alkyl, or -C 1-4 -alkoxy; Z is selected from hydrogen, halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, -CONH 2, -SO 2 NH 2, -NH 2, -NHC 1-4 -alkyl, or-NHhalo-C 1-4 -alkyl; R 1 is a phenyl ring, or a 5 or 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, a 3-7 membered cycloalkyl ring, -OR 5,-NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 4A R 4B, -C NR 4A R 4B, -C R 5, -C OR 5, and -NR 6 S 2 R 5; wherein R 4A, R 4B R 5 and R 6 are each independently selected from hydrogen, C 1-4 -alkyl or halo-C 1-4 -alkyl, or R 4A and R 4B together with the nitrogen to which they are attached form a 3-7 membered cyclic amino group, optionally substituted by one or more substituents selected from: halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, -CONH 2, -SO 2 NH 2, -NH 2, -NHC 1-4 -alkyl, -NHhalo-C 1-4 -alkyl; X is -N=; W is a phenyl ring or a 5 or 6-membered heteroaryl ring selected from pyridinyl, pyridazinyl, pyrazinyl, pyrimidinyl, oxazolyl, thiazolyl or imidazolyl, any of which rings being optionally substituted with one or more substituents selected from halogen, cyano, oxo, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, -OR 5, -NR 7A R 7B,-NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 7A R 7B, -C NR 7A R 7B, -C R 5, -C OR 5,-SO 2 R 5, -SO 2 NR 7A R 7B and -NR 6 S 2 R 5; R 7A and R 7B are independently hydrogen, C 1-4 -alkyl or halo-C 1-4 -alkyl. V is selected from a bond, -O-, -N(R 6)-, -(C=O)-, -CONR 6 -, -NR 6 C -, or -C 1-4 -alkylene-, wherein the C 1-4 -alkylene group is optionally substituted by halogen, and wherein any one of the carbon atoms of the C 1-4 -alkylene group may be replaced by -O- or -N(R 6)-; R 3 is selected from hydrogen, -C 1-4 -alkyl, -C 1-4 -alkyl-C 1-4 -alkoxy or a 3-7 membered heterocyclic ring or 3-7 membered cycloalkyl ring, or a 5 or 6-membered heteroaryl ring, any one of the rings being optionally substituted with one or more substituents selected from halogen, oxo, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, -OR 5, -NR 4A R 4B, -NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 4A R aB,-C NR 4A R 4B, -C R 5, -C OR 5, -SO 2 R 5, -SO 2 NR 4A R 4B and -NR 6 S 2 R 5; PROVIDED THAT groups -WVR 3 and/or R 1 are not: wherein n is 0, 1, or 2; R' and R" are independently selected from the group consisting of H, -C 1 -C 6 alkyl,-(C=O)-C 1 -C 6 alkyl and -(C=O)OC(CH 3) 3; and R''' is H, OH, or C 1 -C 6 alkyl. Y is selected from hydrogen, hydroxyl, -NH 2, -NH-C 1-4 -alkyl, -NH-halo-C 1-4 -alkyl, or -C 1-4 -alkoxy; Z is selected from hydrogen, halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, -CONH 2, -SO 2 NH 2, -NH 2, -NHC 1-4 -alkyl, or-NHhalo-C 1-4 -alkyl; R 1 is a phenyl ring, or a 5 or 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, a 3-7 membered cycloalkyl ring, -OR 5,-NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 4A R 4B, -C NR 4A R 4B, -C R 5, -C OR 5, and -NR 6 S 2 R 5; wherein R 4A, R 4B R 5 and R 6 are each independently selected from hydrogen, C 1-4 -alkyl or halo-C 1-4 -alkyl, or R 4A and R 4B together with the nitrogen to which they are attached form a 3-7 membered cyclic amino group, optionally substituted by one or more substituents selected from: halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, -CONH 2, -SO 2 NH 2, -NH 2, -NHC 1-4 -alkyl, -NHhalo-C 1-4 -alkyl; X is -N=; W is a phenyl ring or a 5 or 6-membered heteroaryl ring selected from pyridinyl, pyridazinyl, pyrazinyl, pyrimidinyl, oxazolyl, thiazolyl or imidazolyl, any of which rings being optionally substituted with one or more substituents selected from halogen, cyano, oxo, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, -OR 5, -NR 7A R 7B,-NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 7A R 7B, -C NR 7A R 7B, -C R 5, -C OR 5,-SO 2 R 5, -SO 2 NR 7A R 7B and -NR 6 S 2 R 5; R 7A and R 7B are independently hydrogen, C 1-4 -alkyl or halo-C 1-4 -alkyl. V is selected from a bond, -O-, -N(R 6)-, -(C=O)-, -CONR 6 -, -NR 6 C -, or -C 1-4 -alkylene-, wherein the C 1-4 -alkylene group is optionally substituted by halogen, and wherein any one of the carbon atoms of the C 1-4 -alkylene group may be replaced by -O- or -N(R 6)-; R 3 is selected from hydrogen, -C 1-4 -alkyl, -C 1-4 -alkyl-C 1-4 -alkoxy or a 3-7 membered heterocyclic ring or 3-7 membered cycloalkyl ring, or a 5 or 6-membered heteroaryl ring, any one of the rings being optionally substituted with one or more substituents selected from halogen, oxo, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, -OR 5, -NR 4A R 4B, -NR 6 C OR 5, -NR 6 C R 5, -NR 6 C NR 4A R aB,-C NR 4A R 4B, -C R 5, -C OR 5, -SO 2 R 5, -SO 2 NR 4A R 4B and -NR 6 S 2 R 5; n is 0, 1, or 2; R' and R" are independently selected from the group consisting of H, -C 1 -C 6 alkyl,-(C=O)-C 1 -C 6 alkyl and -(C=O)OC(CH 3) 3; and R''' is H, OH, or C 1 -C 6 alkyl.