A siRNA, comprising a sense strand and an antisense strand, wherein each nucleotide in the siRNA is independently a modified or unmodified nucleotide, wherein the sense strand comprises a nucleotide sequence I and the antisense strand comprises a nucleotide sequence II, said nucleotide sequence I and said nucleotide sequence II being reverse complementary to form a double-strand region, wherein the nucleotide sequence I comprises a nucleotide sequence represented by SEQ ID NO:3, and the nucleotide sequence II comprises a nucleotide sequence represented by SEQ ID NO:4: 5'-CCAAGAGCACCAAGAACUZ A -3' (SEQ ID NO: 3); 5'-Z' B AGUUCUUGGUGCUCUUGG-3' (SEQ ID NO: 4), wherein, Z A is selected from A, U, G, or C, and Z' B is the first nucleotide at the 5' terminal of the antisense strand and complementary to Z A; and the sense strand and antisense strand have the same or different length, wherein the sense strand has a length of 19 to 23 nucleotides, and the antisense strand has a length of 20 to 26 nucleotides; wherein each nucleotide in the sense strand and the antisense strand is independently a fluoro modified nucleotide or a non-fluoro modified nucleotide; wherein the fluoro modified nucleotide is present in the nucleotide sequence represented by SEQ ID NO:3 and the nucleotide sequence represented by SEQ ID NO:4; and in the direction from 5' terminal to 3' terminal, the nucleotides at positions 7, 8, 9 of the nucleotide sequence represented by SEQ ID NO:3 are fluoro modified nucleotides and the nucleotides at the other positions in the sense strand are non-fluoro modified nucleotides; and in the direction from 5' terminal to 3' terminal, the nucleotides at positions 2, 6, 14 and 16 of the nucleotide sequence represented by SEQ ID NO:4 are fluoro modified nucleotides and the nucleotides at the other positions in the antisense strand are non-fluoro modified nucleotides, wherein the fluoro modified nucleotide refers to a nucleotide formed by replacing 2'-hydroxy of the ribose group with fluoro; and the non-fluoro modified nucleotide refers to a nucleotide formed by replacing 2'-hydroxy of the ribose group with a non-fluoro group. 5'-CCAAGAGCACCAAGAACUZ A -3' (SEQ ID NO: 3); 5'-Z' B AGUUCUUGGUGCUCUUGG-3' (SEQ ID NO: 4), wherein, Z A is selected from A, U, G, or C, and Z' B is the first nucleotide at the 5' terminal of the antisense strand and complementary to Z A; and the sense strand and antisense strand have the same or different length, wherein the sense strand has a length of 19 to 23 nucleotides, and the antisense strand has a length of 20 to 26 nucleotides; wherein each nucleotide in the sense strand and the antisense strand is independently a fluoro modified nucleotide or a non-fluoro modified nucleotide; wherein the fluoro modified nucleotide is present in the nucleotide sequence represented by SEQ ID NO:3 and the nucleotide sequence represented by SEQ ID NO:4; and in the direction from 5' terminal to 3' terminal, the nucleotides at positions 7, 8, 9 of the nucleotide sequence represented by SEQ ID NO:3 are fluoro modified nucleotides and the nucleotides at the other positions in the sense strand are non-fluoro modified nucleotides; and in the direction from 5' terminal to 3' terminal, the nucleotides at positions 2, 6, 14 and 16 of the nucleotide sequence represented by SEQ ID NO:4 are fluoro modified nucleotides and the nucleotides at the other positions in the antisense strand are non-fluoro modified nucleotides, wherein the fluoro modified nucleotide refers to a nucleotide formed by replacing 2'-hydroxy of the ribose group with fluoro; and the non-fluoro modified nucleotide refers to a nucleotide formed by replacing 2'-hydroxy of the ribose group with a non-fluoro group.