An intravaginal device comprising a reservoir surrounded by a water-swellable hydrophilic elastomer; wherein: the water-swellable hydrophilic elastomer is a multiblock poly(ether urethane) comprising poly(ethylene oxide); the reservoir comprises a liquid or semi-solid composition comprising one or more vaginally administrable drugs; wherein: the one or more vaginally administrable drugs is selected from the group consisting of 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopentenylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(4-benzoyl-2,2-dimethylpiperazin-1-yl)-2-(3H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 19-norethindrone, norethisterone, levonorgestrel, norgestrel, norelgestromin, etonogestrel, gestodene, drospirenone, nomegestrol, promegestone, chlormadinone, cyproterone, medroxyprogesterone, megestrol, estrone, estriol, equilenin, equilin, zidovudine, didanosine, stavudine, lamivudine, abacavir, emtricitabine, entecavir, tenofovir, dapivirine, IQP-0528, adefovir, efavirenz, nevirapine, delavirdine, etravirine, rilpivirine, lersivirine, saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, tipranavir, darunavir, elvitegravir, raltegravir, GSK-572, MK-2048, maraviroc, enfuvirtide, acyclovir, penciclovir, imiquimod, resiquimod, cisplatin, doxorubicin, paclitaxel, and combinations of two or more thereof; and the device is an intravaginal ring. the water-swellable hydrophilic elastomer is a multiblock poly(ether urethane) comprising poly(ethylene oxide); the reservoir comprises a liquid or semi-solid composition comprising one or more vaginally administrable drugs; wherein: the one or more vaginally administrable drugs is selected from the group consisting of 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopentenylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(4-benzoyl-2,2-dimethylpiperazin-1-yl)-2-(3H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 19-norethindrone, norethisterone, levonorgestrel, norgestrel, norelgestromin, etonogestrel, gestodene, drospirenone, nomegestrol, promegestone, chlormadinone, cyproterone, medroxyprogesterone, megestrol, estrone, estriol, equilenin, equilin, zidovudine, didanosine, stavudine, lamivudine, abacavir, emtricitabine, entecavir, tenofovir, dapivirine, IQP-0528, adefovir, efavirenz, nevirapine, delavirdine, etravirine, rilpivirine, lersivirine, saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, tipranavir, darunavir, elvitegravir, raltegravir, GSK-572, MK-2048, maraviroc, enfuvirtide, acyclovir, penciclovir, imiquimod, resiquimod, cisplatin, doxorubicin, paclitaxel, and combinations of two or more thereof; and the one or more vaginally administrable drugs is selected from the group consisting of 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopentenylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(cyclopent-3-enylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione, 1-(4-benzoyl-2,2-dimethylpiperazin-1-yl)-2-(3H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 19-norethindrone, norethisterone, levonorgestrel, norgestrel, norelgestromin, etonogestrel, gestodene, drospirenone, nomegestrol, promegestone, chlormadinone, cyproterone, medroxyprogesterone, megestrol, estrone, estriol, equilenin, equilin, zidovudine, didanosine, stavudine, lamivudine, abacavir, emtricitabine, entecavir, tenofovir, dapivirine, IQP-0528, adefovir, efavirenz, nevirapine, delavirdine, etravirine, rilpivirine, lersivirine, saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, tipranavir, darunavir, elvitegravir, raltegravir, GSK-572, MK-2048, maraviroc, enfuvirtide, acyclovir, penciclovir, imiquimod, resiquimod, cisplatin, doxorubicin, paclitaxel, and combinations of two or more thereof; and the device is an intravaginal ring.