A compound of the formula I: wherein: R 1 is C 1-6 alkyl or C 1-6 alkyl-C 3-6 cycloalkyl, which is unsubstituted or substituted with a substituent selected from the group consisting of: C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, -O-phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and -O-heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; R2 is selected from the group consisting of: halogen and -O-C 1-6 alkyl, R3 is C 1-6 alkyl, which is unsubstituted or substituted with halogen; R4 is selected from the group consisting of: hydrogen, and C 1-6 alkyl; R 5 is C 1-6 alkyl, C 1-6 alkyl-C 3-6 cycloalkyl or C 2-6 alkenyl which is unsubstituted or substituted with a substituent selected from the group consisting of: halogen, hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; R6, R 7 and R 8 are independently selected from the group consisting of: halogen, hydroxyl, C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -NR 10 R 11, -(C=O)-NR 10 R 11, -S 2 -NR 10 R 11, -S q -R 12, where q is 0, 1 or 2 and -CN; R 10, R 11 and R 12 are independently selected from the group consisting of hydrogen and C 1-6 alkyl or a pharmaceutically acceptable salt thereof. with the exception of 4-diethylamino-2,6-dimethoxy-5-methyl pyrimidine. R 1 is C 1-6 alkyl or C 1-6 alkyl-C 3-6 cycloalkyl, which is unsubstituted or substituted with a substituent selected from the group consisting of: C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, -O-phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and -O-heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, -O-phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and -O-heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; R2 is selected from the group consisting of: halogen and -O-C 1-6 alkyl, halogen and -O-C 1-6 alkyl, R3 is C 1-6 alkyl, which is unsubstituted or substituted with halogen; R4 is selected from the group consisting of: hydrogen, and C 1-6 alkyl; hydrogen, and C 1-6 alkyl; R 5 is C 1-6 alkyl, C 1-6 alkyl-C 3-6 cycloalkyl or C 2-6 alkenyl which is unsubstituted or substituted with a substituent selected from the group consisting of: halogen, hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; halogen, hydroxyl, -O-C 1-6 alkyl, which is unsubstituted or substituted with halogen or hydroxyl, phenyl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8, and heteroaryl, which is unsubstituted or substituted with one to five substituents selected from R 6, R 7 and R 8; R6, R 7 and R 8 are independently selected from the group consisting of: halogen, hydroxyl, C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -NR 10 R 11, -(C=O)-NR 10 R 11, -S 2 -NR 10 R 11, -S q -R 12, where q is 0, 1 or 2 and -CN; halogen, hydroxyl, C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with fluoro, -NR 10 R 11, -(C=O)-NR 10 R 11, -S 2 -NR 10 R 11, -S q -R 12, where q is 0, 1 or 2 and -CN; R 10, R 11 and R 12 are independently selected from the group consisting of hydrogen and C 1-6 alkyl or a pharmaceutically acceptable salt thereof. with the exception of 4-diethylamino-2,6-dimethoxy-5-methyl pyrimidine.