A fluid injector system, comprising: at least one fluid reservoir having at least one interior surface and defining an internal volume; at least one actuator configured to change the internal volume of the at least one fluid reservoir; and at least one processor programmed or configured to: drive the actuator to at least partially fill the at least one fluid reservoir with a fluid from a fluid source; drive the actuator to generate at least a partial vacuum within the internal volume to dislodge one or more gas bubbles adhered to the at least one interior surface and to cause the one or more gas bubbles to coalesce into a single coalesced bubble; and drive the actuator to expel the single coalesced bubble from an outlet of the at least one fluid reservoir; characterized in that the at least one processor is further programmed or configured to determine and initiate the necessary actuator displacement necessary to achieve the partial vacuum to dislodge the one or more gas bubbles from the at least one interior surface based on at least one of a surface tension of the fluid, a surface tension of the gas, a surface texture of the at least one interior surface, interfacial surface energy between the at least one interior surface and the gas, a weight of the fluid above the one or more gas bubbles in the fluid reservoir, and a buoyancy of the one or more gas bubbles in the fluid. at least one fluid reservoir having at least one interior surface and defining an internal volume; at least one actuator configured to change the internal volume of the at least one fluid reservoir; and at least one processor programmed or configured to: drive the actuator to at least partially fill the at least one fluid reservoir with a fluid from a fluid source; drive the actuator to generate at least a partial vacuum within the internal volume to dislodge one or more gas bubbles adhered to the at least one interior surface and to cause the one or more gas bubbles to coalesce into a single coalesced bubble; and drive the actuator to expel the single coalesced bubble from an outlet of the at least one fluid reservoir; characterized in that the at least one processor is further programmed or configured to determine and initiate the necessary actuator displacement necessary to achieve the partial vacuum to dislodge the one or more gas bubbles from the at least one interior surface based on at least one of a surface tension of the fluid, a surface tension of the gas, a surface texture of the at least one interior surface, interfacial surface energy between the at least one interior surface and the gas, a weight of the fluid above the one or more gas bubbles in the fluid reservoir, and a buoyancy of the one or more gas bubbles in the fluid. drive the actuator to at least partially fill the at least one fluid reservoir with a fluid from a fluid source; drive the actuator to generate at least a partial vacuum within the internal volume to dislodge one or more gas bubbles adhered to the at least one interior surface and to cause the one or more gas bubbles to coalesce into a single coalesced bubble; and drive the actuator to expel the single coalesced bubble from an outlet of the at least one fluid reservoir; characterized in that the at least one processor is further programmed or configured to determine and initiate the necessary actuator displacement necessary to achieve the partial vacuum to dislodge the one or more gas bubbles from the at least one interior surface based on at least one of a surface tension of the fluid, a surface tension of the gas, a surface texture of the at least one interior surface, interfacial surface energy between the at least one interior surface and the gas, a weight of the fluid above the one or more gas bubbles in the fluid reservoir, and a buoyancy of the one or more gas bubbles in the fluid.