A multimodal imaging system configured to produce enhanced X-ray images of a blood vessel/myocardium, the multimodal imaging system comprising: - an X-ray/fluoro imaging system configured to: obtain a first set of X-ray images of the blood vessel/myocardium over a single cardiac cycle; and obtain a second set of X-ray images of the blood vessel/myocardium over a number of cardiac cycles; - an intravascular imaging system configured to obtain a set of intravascular images of the blood vessel/myocardium concurrently with the obtaining of the second set of X-ray images; and - a processing unit configured to: synchronize the set of intravascular images and the second set of X-ray images with regard to the time each of the set of intravascular images and each of the second set of X-ray images was obtained; and overlay one of the first set of X-ray images with a corresponding one of the second set of X-ray images to produce a combined X-ray image, wherein the processing unit being configured to overlay the one of the first set of X-ray images with the one of the second set of X-ray images comprises the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images, wherein the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images comprises the processing unit being configured to combine the first set of X-ray images to form a small video loop covering the single cardiac cycle; and overlay each of the second set of X-ray images with the one of the first set of X-ray images corresponding to their respective positions within the respective cardiac cycles to form a video of the sequence of multiple cardiac cycles covered by the second set of X-ray images. - an X-ray/fluoro imaging system configured to: obtain a first set of X-ray images of the blood vessel/myocardium over a single cardiac cycle; and obtain a second set of X-ray images of the blood vessel/myocardium over a number of cardiac cycles; obtain a first set of X-ray images of the blood vessel/myocardium over a single cardiac cycle; and obtain a second set of X-ray images of the blood vessel/myocardium over a number of cardiac cycles; - an intravascular imaging system configured to obtain a set of intravascular images of the blood vessel/myocardium concurrently with the obtaining of the second set of X-ray images; and - a processing unit configured to: synchronize the set of intravascular images and the second set of X-ray images with regard to the time each of the set of intravascular images and each of the second set of X-ray images was obtained; and overlay one of the first set of X-ray images with a corresponding one of the second set of X-ray images to produce a combined X-ray image, wherein the processing unit being configured to overlay the one of the first set of X-ray images with the one of the second set of X-ray images comprises the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images, wherein the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images comprises the processing unit being configured to combine the first set of X-ray images to form a small video loop covering the single cardiac cycle; and overlay each of the second set of X-ray images with the one of the first set of X-ray images corresponding to their respective positions within the respective cardiac cycles to form a video of the sequence of multiple cardiac cycles covered by the second set of X-ray images. synchronize the set of intravascular images and the second set of X-ray images with regard to the time each of the set of intravascular images and each of the second set of X-ray images was obtained; and overlay one of the first set of X-ray images with a corresponding one of the second set of X-ray images to produce a combined X-ray image, wherein the processing unit being configured to overlay the one of the first set of X-ray images with the one of the second set of X-ray images comprises the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images, wherein the processing unit being configured to process at least one of the first set of X-ray images or at least one of the second set of X-ray images comprises the processing unit being configured to combine the first set of X-ray images to form a small video loop covering the single cardiac cycle; and overlay each of the second set of X-ray images with the one of the first set of X-ray images corresponding to their respective positions within the respective cardiac cycles to form a video of the sequence of multiple cardiac cycles covered by the second set of X-ray images.