A compound of formula: wherein X 4 -X 5 is chosen from CR 4 -CR 5, N-CR 5 and CR 4 -N; R 1 is chosen from (C 1-10)alkyl, (C 3-10)cycloalkyl, and [(C 3-10)cycloalkyl(C 1-2)alkyl], said (C 1-10)alkyl, (C 3-10)cycloalkyl, and [(C 3-10)cycloalkyl(C 1-2)alkyl] being optionally substituted with one or more halogens, (C 1-6)alkoxy, phenyl or benzyl; Ar is chosen from (C 6-10)aryl, optionally substituted within 1-3 substituents selected from halogen, hydroxy, (C 1-6)alkyl, (C 3-6)cycloalkyl, (C 1-6)alkyloxy and (C 3-6)cycloalkyloxy, said (C 1-6)alkyl, (C 3-6)cycloalkyl, (C 1-6)alkyloxy and (C 3-6)cycloalkyloxy being optionally substituted with one or more halogens; R 4 and R 5 are independently chosen from H, (C 1-6)alkyl, (C 1-6)alkyloxy or halogen, said (C 1-6)alkyl, (C 1-6)alkyloxy being optionally substituted with one or more halogens; G is a linking moiety spanning 4 to 7 atoms between termini, wherein G is a C 4 -C 7 alkylene in which one or more CH 2 may be replaced by O, C(=O), NH, CH(C 1-6 alkyl) or C(C 1-6 alkyl) 2, with the provisos that adjacent CH 2 residues cannot be replaced by O and O and NH residues cannot be separated only by a single carbon or G is a carbocycle, a heterocycle attached to the B ring and NR 8 R 9 by a direct bond or by a C 1 -C 5 alkylene chain or G is a nitrogenous heterocycle attached to the B ring by a direct bond or by a C 1 -C 5 alkylene chain, wherein a nitrogen of the nitrogenous heterocycle may correspond to NR 8 R 9 so that R 9 formally becomes part of G; or G is (NR 10)C 3-6 alkylene, wherein R 10 is H or C 1-6 alkyl and when G is (NR 10)C 3-6 alkylene, R 8 and R 9 together form a 4- to 7- membered nitrogenous heterocycle; R 8 and R 9 are independently C 1-6 alkyl or R 8 and R 9 together form a 4- to 7-membered nitrogenous heterocycle with the proviso that when G is (NR 10)C 3-6 alkylene, wherein R 10 is H or C 1-6 alkyl, R 8 and R 9 together form a 4- to 7- membered nitrogenous heterocycle; with the proviso that when X 4 -X 5 is CR 4 -N and G is alkylene, R 1 is chosen from (C 1-6)alkyl, (C 3-6)cycloalkyl and [(C 3-6)cycloalkyl (C 1-2)alkyl]. X 4 -X 5 is chosen from CR 4 -CR 5, N-CR 5 and CR 4 -N; R 1 is chosen from (C 1-10)alkyl, (C 3-10)cycloalkyl, and [(C 3-10)cycloalkyl(C 1-2)alkyl], said (C 1-10)alkyl, (C 3-10)cycloalkyl, and [(C 3-10)cycloalkyl(C 1-2)alkyl] being optionally substituted with one or more halogens, (C 1-6)alkoxy, phenyl or benzyl; Ar is chosen from (C 6-10)aryl, optionally substituted within 1-3 substituents selected from halogen, hydroxy, (C 1-6)alkyl, (C 3-6)cycloalkyl, (C 1-6)alkyloxy and (C 3-6)cycloalkyloxy, said (C 1-6)alkyl, (C 3-6)cycloalkyl, (C 1-6)alkyloxy and (C 3-6)cycloalkyloxy being optionally substituted with one or more halogens; R 4 and R 5 are independently chosen from H, (C 1-6)alkyl, (C 1-6)alkyloxy or halogen, said (C 1-6)alkyl, (C 1-6)alkyloxy being optionally substituted with one or more halogens; G is a linking moiety spanning 4 to 7 atoms between termini, wherein G is a C 4 -C 7 alkylene in which one or more CH 2 may be replaced by O, C(=O), NH, CH(C 1-6 alkyl) or C(C 1-6 alkyl) 2, with the provisos that adjacent CH 2 residues cannot be replaced by O and O and NH residues cannot be separated only by a single carbon or adjacent CH 2 residues cannot be replaced by O and O and NH residues cannot be separated only by a single carbon or G is a carbocycle, a heterocycle attached to the B ring and NR 8 R 9 by a direct bond or by a C 1 -C 5 alkylene chain or G is a nitrogenous heterocycle attached to the B ring by a direct bond or by a C 1 -C 5 alkylene chain, wherein a nitrogen of the nitrogenous heterocycle may correspond to NR 8 R 9 so that R 9 formally becomes part of G; or G is (NR 10)C 3-6 alkylene, wherein R 10 is H or C 1-6 alkyl and when G is (NR 10)C 3-6 alkylene, R 8 and R 9 together form a 4- to 7- membered nitrogenous heterocycle; R 8 and R 9 are independently C 1-6 alkyl or R 8 and R 9 together form a 4- to 7-membered nitrogenous heterocycle with the proviso that when G is (NR 10)C 3-6 alkylene, wherein R 10 is H or C 1-6 alkyl, R 8 and R 9 together form a 4- to 7- membered nitrogenous heterocycle; with the proviso that when X 4 -X 5 is CR 4 -N and G is alkylene, R 1 is chosen from (C 1-6)alkyl, (C 3-6)cycloalkyl and [(C 3-6)cycloalkyl (C 1-2)alkyl].