A compound of Formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is selected from the group consisting of halogen, cyano, nitro, optionally substituted amino, optionally substituted C 1 to C 6 alkoxy, optionally substituted C 1 to C 6 alkyl, optionally substituted C 3 to C 8 carbocyclyl, optionally substituted C 6 to C 10 aryl, optionally substituted 3-30 membered heterocyclyl, and optionally substituted 5-10 membered heteroaryl; R 2, R 3, and R 4, are each independently selected from the group consisting of H, deuterium, halogen, cyano, nitro, optionally substituted amino, optionally substituted C 1 to C 6 alkoxy, optionally substituted C 1 to C 6 alkyl, optionally substituted C 2 to C 6 alkenyl, optionally substituted C 2 to C 6 alkynyl, optionally substituted C 3 to C 8 carbocyclyl, optionally substituted C 6 to C 10 aryl, optionally substituted 3-30 membered heterocyclyl, and optionally substituted 5-10 membered heteroaryl; R 5 is selected from the group consisting of H, deuterium, and unsubstituted C 1 to C 6 alkyl; X is CH 2 or C=O; Q is C=O; and n is 1 or 2; wherein an optionally substituted substituent may be substituted with one or more groups selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, hydroxy, protected hydroxyl, alkoxy, aryloxy, acyl, mercapto, alkylthio, arylthio, cyano, halogen, thiocarbonyl, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, C-carboxy, protected C-carboxy, O-carboxy, isocyanato, thiocyanato, isothiocyanato, nitro, silyl, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, trihalomethanesulfonyl, trihalomethanesulfonamido, amino, mono-substituted amino and di-substituted amino. R 1 is selected from the group consisting of halogen, cyano, nitro, optionally substituted amino, optionally substituted C 1 to C 6 alkoxy, optionally substituted C 1 to C 6 alkyl, optionally substituted C 3 to C 8 carbocyclyl, optionally substituted C 6 to C 10 aryl, optionally substituted 3-30 membered heterocyclyl, and optionally substituted 5-10 membered heteroaryl; R 2, R 3, and R 4, are each independently selected from the group consisting of H, deuterium, halogen, cyano, nitro, optionally substituted amino, optionally substituted C 1 to C 6 alkoxy, optionally substituted C 1 to C 6 alkyl, optionally substituted C 2 to C 6 alkenyl, optionally substituted C 2 to C 6 alkynyl, optionally substituted C 3 to C 8 carbocyclyl, optionally substituted C 6 to C 10 aryl, optionally substituted 3-30 membered heterocyclyl, and optionally substituted 5-10 membered heteroaryl; R 5 is selected from the group consisting of H, deuterium, and unsubstituted C 1 to C 6 alkyl; X is CH 2 or C=O; Q is C=O; and n is 1 or 2; wherein an optionally substituted substituent may be substituted with one or more groups selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, hydroxy, protected hydroxyl, alkoxy, aryloxy, acyl, mercapto, alkylthio, arylthio, cyano, halogen, thiocarbonyl, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, C-carboxy, protected C-carboxy, O-carboxy, isocyanato, thiocyanato, isothiocyanato, nitro, silyl, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, trihalomethanesulfonyl, trihalomethanesulfonamido, amino, mono-substituted amino and di-substituted amino.