A compounds of formula wherein R 1 is C 1-6 alkyl; R 2 is phenyl, which is once or twice or three times substituted by halogen or C 1-6 alkyl; R 3 is hydrogen or C 1-6 alkyl; R 4 is wherein one of R 5a and R 6a is hydrogen or halogen, and the other one is hydrogen, halogen or hydroxy; one of R 5b and R 6b is hydrogen or halogen, and the other one is hydrogen or halogen; R 9 is hydrogen or carboxy; one of R 17 and R 18 is hydrogen, halogen, hydroxy, amino, C 1-6 alkylsulfonylamino or trifluoromethylcarbonylamino, the other one is hydrogen, halogen, hydroxy-C y H 2y -, C 1-6 alkylcarbonyl-O-, C 1-6 alkoxycarbonyl-C y H 2y -, carboxy-C y H 2y -O-, carboxy-C y H 2y -, C 1-6 alkylcarbonyl-NH-, C 1-6 alkylsulfonyl-NH-, aminocarbonyl-NH- or aminosulfonyl-NH-; wherein -C y H 2y - is unsubstituted once or more times substituted by hydroxy; or R 6a and R 17 together with the carbon atoms, to which they are attached, form a ring of isoxazolyl, pyrazolyl or oxo-dihydropyrazolyl, which ring is unsubstituted or once or more times substituted by C 1-6 alkyl; or R 17 and R 18 together with the carbon atom, to which they are attached, form diazirinyl; X is oxygen; sulfur; -N(carbonylC 1-6 alkyl)-; or -C(R 15 R 16)-, wherein one of R 15 and R 16 is hydrogen or hydroxy, and the other one is hydrogen or carboxy-C y H 2y -; r is 0 or 1; m is 0 or 1; n is 0 or 1; y is 0-6; or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. R 1 is C 1-6 alkyl; R 2 is phenyl, which is once or twice or three times substituted by halogen or C 1-6 alkyl; R 3 is hydrogen or C 1-6 alkyl; R 4 is wherein one of R 5a and R 6a is hydrogen or halogen, and the other one is hydrogen, halogen or hydroxy; one of R 5b and R 6b is hydrogen or halogen, and the other one is hydrogen or halogen; R 9 is hydrogen or carboxy; one of R 17 and R 18 is hydrogen, halogen, hydroxy, amino, C 1-6 alkylsulfonylamino or trifluoromethylcarbonylamino, the other one is hydrogen, halogen, hydroxy-C y H 2y -, C 1-6 alkylcarbonyl-O-, C 1-6 alkoxycarbonyl-C y H 2y -, carboxy-C y H 2y -O-, carboxy-C y H 2y -, C 1-6 alkylcarbonyl-NH-, C 1-6 alkylsulfonyl-NH-, aminocarbonyl-NH- or aminosulfonyl-NH-; wherein -C y H 2y - is unsubstituted once or more times substituted by hydroxy; or R 6a and R 17 together with the carbon atoms, to which they are attached, form a ring of isoxazolyl, pyrazolyl or oxo-dihydropyrazolyl, which ring is unsubstituted or once or more times substituted by C 1-6 alkyl; or R 17 and R 18 together with the carbon atom, to which they are attached, form diazirinyl; X is oxygen; sulfur; -N(carbonylC 1-6 alkyl)-; or -C(R 15 R 16)-, wherein one of R 15 and R 16 is hydrogen or hydroxy, and the other one is hydrogen or carboxy-C y H 2y -; r is 0 or 1; m is 0 or 1; n is 0 or 1; y is 0-6; or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. wherein one of R 5a and R 6a is hydrogen or halogen, and the other one is hydrogen, halogen or hydroxy; one of R 5b and R 6b is hydrogen or halogen, and the other one is hydrogen or halogen; R 9 is hydrogen or carboxy; one of R 17 and R 18 is hydrogen, halogen, hydroxy, amino, C 1-6 alkylsulfonylamino or trifluoromethylcarbonylamino, the other one is hydrogen, halogen, hydroxy-C y H 2y -, C 1-6 alkylcarbonyl-O-, C 1-6 alkoxycarbonyl-C y H 2y -, carboxy-C y H 2y -O-, carboxy-C y H 2y -, C 1-6 alkylcarbonyl-NH-, C 1-6 alkylsulfonyl-NH-, aminocarbonyl-NH- or aminosulfonyl-NH-; wherein -C y H 2y - is unsubstituted once or more times substituted by hydroxy; or R 6a and R 17 together with the carbon atoms, to which they are attached, form a ring of isoxazolyl, pyrazolyl or oxo-dihydropyrazolyl, which ring is unsubstituted or once or more times substituted by C 1-6 alkyl; or R 17 and R 18 together with the carbon atom, to which they are attached, form diazirinyl; X is oxygen; sulfur; -N(carbonylC 1-6 alkyl)-; or -C(R 15 R 16)-, wherein one of R 15 and R 16 is hydrogen or hydroxy, and the other one is hydrogen or carboxy-C y H 2y -; r is 0 or 1; m is 0 or 1; n is 0 or 1; y is 0-6;