mhurhangee/ep-ind-claims huggingface dataset:
A method of identifying a candidate kinetic modulating antibody that modulates binding between first and second components of a signaling complex, comprising the steps of: (a) (i) measuring a binding affinity or binding rate parameter of a test antibody for said first component in the presence of said second component, or (ii) measuring a binding affinity or binding rate parameter of a test antibody for said second component in the presence of said first component; and (b) (i) measuring a binding affinity or binding rate parameter of said test antibody for said first component in the absence of said second component, or (ii) measuring a binding affinity or binding rate parameter of said test antibody for said second component in the absence of said first component; and (c) identifying said test antibody as a candidate kinetic modulating antibody when said test antibody exhibits a 1.5-fold to 1000-fold difference in the binding affinity or binding rate parameter measured in steps (a) and (b), wherein the difference is between (a)(i) and (b)(i) or (a)(ii) and (b)(ii), wherein the binding affinity or binding rate parameter is any one of the equilibrium association constant K A, the equilibrium dissociation constant K D, on rate or off rate. (a) (i) measuring a binding affinity or binding rate parameter of a test antibody for said first component in the presence of said second component, or (ii) measuring a binding affinity or binding rate parameter of a test antibody for said second component in the presence of said first component; and (b) (i) measuring a binding affinity or binding rate parameter of said test antibody for said first component in the absence of said second component, or (ii) measuring a binding affinity or binding rate parameter of said test antibody for said second component in the absence of said first component; and (c) identifying said test antibody as a candidate kinetic modulating antibody when said test antibody exhibits a 1.5-fold to 1000-fold difference in the binding affinity or binding rate parameter measured in steps (a) and (b), wherein the difference is between (a)(i) and (b)(i) or (a)(ii) and (b)(ii),
A solid pharmaceutical composition for oral administration comprising; i. a core comprising a proton pump inhibitor, an antacid and one or more pharmaceutically acceptable excipients ii. an intermediate layer, and iii. an enteric coating layer characterized in that, a. the intermediate layer comprises a cellulosic polymer, b. the enteric coating layer comprises a polymer composition and optionally a plasticizer, said polymer composition comprising two enteric polymers having different solubility characteristics which are; - hydroxypropylmethyl cellulose acetate succinate having a higher grade, having pH solubility ≥ 6.8 or ≥6.0 and - hydroxylpropylmethyl cellulose acetate succinate having a lower grade, having a pH solubility ≥5.5 or ≥6.0. i. a core comprising a proton pump inhibitor, an antacid and one or more pharmaceutically acceptable excipients ii. an intermediate layer, and iii. an enteric coating layer a. the intermediate layer comprises a cellulosic polymer, b. the enteric coating layer comprises a polymer composition and optionally a plasticizer, said polymer composition comprising two enteric polymers having different solubility characteristics which are; - hydroxypropylmethyl cellulose acetate succinate having a higher grade, having pH solubility ≥ 6.8 or ≥6.0 and - hydroxylpropylmethyl cellulose acetate succinate having a lower grade, having a pH solubility ≥5.5 or ≥6.0. - hydroxypropylmethyl cellulose acetate succinate having a higher grade, having pH solubility ≥ 6.8 or ≥6.0 and - hydroxylpropylmethyl cellulose acetate succinate having a lower grade, having a pH solubility ≥5.5 or ≥6.0.
A method of manufacturing an oral device, comprising: directly fabricating a plurality of layers of photopolymer resin to form a body comprising a lower substantially planar surface and an upper surface; and wherein the lower, planar surface is fabricated directly to a build platform and wherein at least a first one of the plurality of layers is cured with a first dose to a first strength and at least a second one of the plurality of layers is cured with a second dose to a second strength to inhibit warpage of the body, wherein a first layer at the planar surface and a second layer at the upper surface are directly fabricated with a greater amount of polymer cross-linking than an amount of polymer cross-linking of an inner plurality of layers between the first layer and the second layer, wherein the amount of cross-linking is controlled by the amount of light energy used to cure the layers. directly fabricating a plurality of layers of photopolymer resin to form a body comprising a lower substantially planar surface and an upper surface; and wherein the lower, planar surface is fabricated directly to a build platform and wherein at least a first one of the plurality of layers is cured with a first dose to a first strength and at least a second one of the plurality of layers is cured with a second dose to a second strength to inhibit warpage of the body, wherein a first layer at the planar surface and a second layer at the upper surface are directly fabricated with a greater amount of polymer cross-linking than an amount of polymer cross-linking of an inner plurality of layers between the first layer and the second layer, wherein the amount of cross-linking is controlled by the amount of light energy used to cure the layers.
A turbine bucket comprising: a radially inner mounting portion, a shank radially outward of the mounting portion, a radially outer airfoil and a substantially planar platform radially between the shank and the airfoil; at least one axially-extending angel wing seal flange on a leading end of the shank thus forming a circumferentially extending trench cavity along the leading end of the shank, radially between an underside of the platform leading edge and the angel wing seal flange; and a plurality of grooves formed on a radially outer surface of said angel wing seal flange and extending into said shank, characterised in that the grooves extend axially along their length on an outer surface of the angel wing seal flange; and said plurality of grooves are substantially non-uniformly distributed in a circumferential direction along said trench cavity. a radially inner mounting portion, a shank radially outward of the mounting portion, a radially outer airfoil and a substantially planar platform radially between the shank and the airfoil; at least one axially-extending angel wing seal flange on a leading end of the shank thus forming a circumferentially extending trench cavity along the leading end of the shank, radially between an underside of the platform leading edge and the angel wing seal flange; and a plurality of grooves formed on a radially outer surface of said angel wing seal flange and extending into said shank, characterised in that the grooves extend axially along their length on an outer surface of the angel wing seal flange; and said plurality of grooves are substantially non-uniformly distributed in a circumferential direction along said trench cavity.
A method of measuring a clearance of a hub bearing for vehicles when assembling the hub bearing, comprising: fixing a hub to a frame when an inner ring is disposed on an outer periphery of the hub to be mounted to an axle and an outer ring is disposed to be opposed to an upper portion of the inner ring and a row of balls is disposed between the outer ring and the inner ring opposed thereto; applying a load to an outer surface of the outer ring so as to prevent a movement of the outer ring caused by a vibration that occurs during press-fitting of the inner ring; contacting a press-fit jig to an outer surface of the inner ring and gradually press-fitting the inner ring to the hub; measuring a positional variation of the outer ring and a positional variation of the press-fit jig by an external measuring instrument; measuring a displacement of an end surface of the inner ring when a movement of the outer ring appears after the inner ring is brought into contact with the row of balls; measuring a displacement of the end surface of the inner ring after completely press-fitting the inner ring to the hub; and measuring the amount of clearance of the hub bearing by subtracting G1 from G2. fixing a hub to a frame when an inner ring is disposed on an outer periphery of the hub to be mounted to an axle and an outer ring is disposed to be opposed to an upper portion of the inner ring and a row of balls is disposed between the outer ring and the inner ring opposed thereto; applying a load to an outer surface of the outer ring so as to prevent a movement of the outer ring caused by a vibration that occurs during press-fitting of the inner ring; contacting a press-fit jig to an outer surface of the inner ring and gradually press-fitting the inner ring to the hub; measuring a positional variation of the outer ring and a positional variation of the press-fit jig by an external measuring instrument; measuring a displacement of an end surface of the inner ring when a movement of the outer ring appears after the inner ring is brought into contact with the row of balls; measuring a displacement of the end surface of the inner ring after completely press-fitting the inner ring to the hub; and measuring the amount of clearance of the hub bearing by subtracting G1 from G2.
A wireless power transmitting device for a wireless power communication system, comprising: a circuit board including an insulating layer and a ground formed on the insulating layer; a core of a magnetic substance disposed on the circuit board to have a concave portion; a coil accommodated in the concave portion to have one end for receiving a power through the circuit board and the other end connected to the ground; and a metal layer disposed between the core and the insulating layer to be connected to the ground; and a magnetic sheet disposed between the core and the metal layer, wherein the metal layer includes a first metal layer attached on the insulating layer of the circuit board and a second metal layer disposed between the core and the first metal layer. a circuit board including an insulating layer and a ground formed on the insulating layer; a core of a magnetic substance disposed on the circuit board to have a concave portion; a coil accommodated in the concave portion to have one end for receiving a power through the circuit board and the other end connected to the ground; and a metal layer disposed between the core and the insulating layer to be connected to the ground; and a magnetic sheet disposed between the core and the metal layer, wherein the metal layer includes a first metal layer attached on the insulating layer of the circuit board and a second metal layer disposed between the core and the first metal layer.
A supply device designed for supplying a fluid to a mixing chamber of a spraying device by means of which, in use, a layer of coating material is applied to a surface, wherein the supply device comprises a first store of base material, the mixing chamber, a first supply channel providing a supply route from the first store of base material to the mixing chamber and provided with a first flow resistor which prevents flow in a desired direction of flow from the first store of base material in the form of a fluid to the mixing chamber until the pressure difference between the first supply channel and the mixing chamber exceeds a first specific threshold value, and which blocks flow of fluid against the desired direction of flow, and wherein the supply device comprises a second store of base material, a second supply channel providing a supply route from the second store of base material to the mixing chamber provided with a second flow resistor which prevents flow in a desired direction of flow from the second store of base material in the form of fluid to the mixing chamber until a pressure difference between the second supply channel and the mixing chamber exceeds a specific second threshold value and which blocks flow of fluid against the desired direction of flow, wherein the first threshold value for the pressure difference between the first supply channel from a first base material supply line and the mixing chamber is at least 10 kPa and wherein the second threshold value for the pressure difference between the second supply channel from a second supply line and the mixing chamber is at least 10 kPa.
A dermal adhesive in the form of a porous membrane formed through irradiation of a radiation-curable resin with radiation rays, having a porosity of 5 to 90%, wherein fibrous resins and particulate resins containing the radiation-curable resin are aggregated to define voids between the fibrous resins and/or the particulate resins, to be prepared in the form of the porous membrane, wherein the fiber diameter of each of the fibrous resins is from 1 to 1000 μm, the length of each of the fibrous resins is from 0.1 to 10 mm, and the particle size of each of the particulate resins is from 1 to 1000 μm.
A rocket engine with the multi-stage combustion of a mixture of propellants, having at least one pre-combustion chamber and a main combustion chamber, a propellant mixture supply system to these chambers, including a fuel and oxidizer pumps, and an exhaust gas nozzle, characterized in that it has at least one staged detonation chamber, including at least two preliminary detonation chambers (1, 2), and at their outlet, a post-combustion chamber, where full mixing and post-combustion of detonation products from the pre-chambers (1, 2) takes place, and exhaust gases are directed outside through a nozzle, preferably of the Aerospike type.
An autoinjector comprising: a case having a hole; a carrier adapted to hold a syringe with a needle coupled to a distal end of the syringe, wherein the carrier is slidably disposed in the case; a cover telescopically coupled to the case and translatable relative to the case between a first position allowing an unused syringe to be inserted into the carrier and a used syringe to be removed from the carrier and a second position, wherein in the second position, the cover covers the hole; and a releasable locking mechanism adapted to lock the cover in the second position, a plunger adapted to advance a stopper in the syringe; a motor adapted to advance the carrier for needle insertion and push the plunger to advance the stopper in the syringe; and characterized in a gear train operably coupled to the motor, the gear train including a pinion adapted to actuate a rack disposed on the plunger. a case having a hole; a carrier adapted to hold a syringe with a needle coupled to a distal end of the syringe, wherein the carrier is slidably disposed in the case; a cover telescopically coupled to the case and translatable relative to the case between a first position allowing an unused syringe to be inserted into the carrier and a used syringe to be removed from the carrier and a second position, wherein in the second position, the cover covers the hole; and a releasable locking mechanism adapted to lock the cover in the second position, a plunger adapted to advance a stopper in the syringe;
An electronic device comprising: a microphone configured to receive a voice (201, 431); communication circuitry configured to communicate with an external electronic device; a memory; and a processor operatively connected to the microphone, the communication circuitry, and the memory, wherein the memory stores instructions that, when executed by the processor, cause the electronic device to: perform voice recognition (230, 432) for voice data corresponding to the voice, wherein at least a first expression is included in a result of the voice recognition, wherein the first expression is an instruction associated with an object; determine (434, 435) to perform voiceprint recognition for the voice data based on a security level of the instruction; determine a security level of the object associated with the instruction, wherein the security level of the object is based on a correlation with the instruction and a type of the object such as a user or a device; and adjust a sensitivity of the voiceprint recognition based on the security level of the object. a microphone configured to receive a voice (201, 431); communication circuitry configured to communicate with an external electronic device; a memory; and a processor operatively connected to the microphone, the communication circuitry, and the memory, wherein the memory stores instructions that, when executed by the processor, cause the electronic device to: perform voice recognition (230, 432) for voice data corresponding to the voice, wherein at least a first expression is included in a result of the voice recognition, wherein the first expression is an instruction associated with an object; determine (434, 435) to perform voiceprint recognition for the voice data based on a security level of the instruction; determine a security level of the object associated with the instruction, wherein the security level of the object is based on a correlation with the instruction and a type of the object such as a user or a device; and adjust a sensitivity of the voiceprint recognition based on the security level of the object. perform voice recognition (230, 432) for voice data corresponding to the voice, wherein at least a first expression is included in a result of the voice recognition, wherein the first expression is an instruction associated with an object; determine (434, 435) to perform voiceprint recognition for the voice data based on a security level of the instruction; determine a security level of the object associated with the instruction, wherein the security level of the object is based on a correlation with the instruction and a type of the object such as a user or a device; and adjust a sensitivity of the voiceprint recognition based on the security level of the object.
A tracker system for a head or helmet mounted digital display device arranged to display space-stabilised symbols or other space-stabilised display artefacts, the tracker system for determining orientation of an object, comprising: a sensor arrangement associated with the object, arranged to output rate data providing a cyclic indication of a rate of change in orientation of the object; a predictor component arranged to receive rate data output by the sensor arrangement and to determine from the received rate data an orientation of the object at a predetermined prediction time period ahead of a time point of validity of the received rate data; a buffeting measurement component arranged to receive rate data output by the sensor arrangement and to determine therefrom a measure of buffeting severity upon the object; a buffeting compensation component arranged to adjust the operation of the predictor component to compensate for a determined measure of buffeting severity by the buffeting measurement component; and wherein the object is a head or a helmet on which is mounted the head or helmet-mounted display and wherein the predetermined prediction time period corresponds to an expected time of displaying a space-stabilised symbol or other space-stabilised display artefact positioned by the display device to take account of an orientation of the head or helmet indicated by an output of predicted orientation by the tracker system. a sensor arrangement associated with the object, arranged to output rate data providing a cyclic indication of a rate of change in orientation of the object; a predictor component arranged to receive rate data output by the sensor arrangement and to determine from the received rate data an orientation of the object at a predetermined prediction time period ahead of a time point of validity of the received rate data; a buffeting measurement component arranged to receive rate data output by the sensor arrangement and to determine therefrom a measure of buffeting severity upon the object; a buffeting compensation component arranged to adjust the operation of the predictor component to compensate for a determined measure of buffeting severity by the buffeting measurement component; and wherein the object is a head or a helmet on which is mounted the head or helmet-mounted display and wherein the predetermined prediction time period corresponds to an expected time of displaying a space-stabilised symbol or other space-stabilised display artefact positioned by the display device to take account of an orientation of the head or helmet indicated by an output of predicted orientation by the tracker system.
A system for solid freeform fabrication of a three-dimensional object, comprising: a solid freeform fabrication apparatus that deposits small beads of building materials in a controlled manner; wherein said building materials comprises a thermoplastic polyurethane derived from (a) a polyisocyanate component, (b) a polyol component, and (c) an optional chain extender component; wherein the resulting thermoplastic polyurethane has a crystallization temperature above 80°C; wherein the resulting thermoplastic polyurethane retains more than 20% of its shear storage modulus at 100°C relative to its shear storage modulus at 20°C, where the modulus is measured according to ASTM D5279; and wherein the polyol component comprises a polyether polyol or a combination of a polyether polyol and a polyester polyol. wherein said building materials comprises a thermoplastic polyurethane derived from (a) a polyisocyanate component, (b) a polyol component, and (c) an optional chain extender component; wherein the resulting thermoplastic polyurethane has a crystallization temperature above 80°C; wherein the resulting thermoplastic polyurethane retains more than 20% of its shear storage modulus at 100°C relative to its shear storage modulus at 20°C, where the modulus is measured according to ASTM D5279; and wherein the polyol component comprises a polyether polyol or a combination of a polyether polyol and a polyester polyol.
A printed nonwoven web comprising a pattern of fusion-embossed bonding points, wherein the nonwoven web is ink-printed on the surface showing the pattern of bonding points, characterized in that the pattern of bonding points is homogenous over the entire surface of the fabric and fulfils the following conditions: (a) the number of bonding points on the surface is greater than 70/cm 2, preferably greater than 75/cm 2; (b) the average area size of the individual bonding points is smaller than 1.5 mm 2, preferably smaller than 1.35 mm 2; and (c) the average distance between bonding points, from centre to centre, is smaller than 1.5 mm, preferably smaller than 1.3 mm. (a) the number of bonding points on the surface is greater than 70/cm 2, preferably greater than 75/cm 2; (b) the average area size of the individual bonding points is smaller than 1.5 mm 2, preferably smaller than 1.35 mm 2; and (c) the average distance between bonding points, from centre to centre, is smaller than 1.5 mm, preferably smaller than 1.3 mm.
A pancreatic cancer determination marker comprising a sugar chain represented by the formula 5 present in inter-alpha trypsin inhibitor heavy chain H3; in the formula 5, n2 represents 0 or 1.