A human body simulation device (1,1e,1f) comprising: an aorta model (160,160a) that simulates an aorta; and a biological model (110,110b,120,130,140,150,170) that has a partial blood vessel model (111,131,141,151) simulating a part of blood vessels and simulates a part of a human body, wherein the aorta model (160,160a) comprises: a biological model connecting portion (161J,162J,163Ja,164J) that attachably/detachably connects the biological model (110,110b,120,130,140,150,170) in a state where an inner cavity of the aorta model (160,160a) and an inner cavity of the partial blood vessel model (111,131,141,151) communicate with each other; and a fluid feeding portion connecting portion that connects a fluid feeding portion for feeding a fluid into the inner cavities, characterized in that the biological model connecting portion (161J, 162J, 163Ja, 164J) comprises at least two or more of: a first connection portion for connecting a brain model simulating a brain; a second connection portion for connecting a heart model simulating a heart; a third connection portion for connecting a liver model simulating a liver; and a fourth connection portion for connecting a lower limb model simulating a lower limb. an aorta model (160,160a) that simulates an aorta; and a biological model (110,110b,120,130,140,150,170) that has a partial blood vessel model (111,131,141,151) simulating a part of blood vessels and simulates a part of a human body, wherein the aorta model (160,160a) comprises: a biological model connecting portion (161J,162J,163Ja,164J) that attachably/detachably connects the biological model (110,110b,120,130,140,150,170) in a state where an inner cavity of the aorta model (160,160a) and an inner cavity of the partial blood vessel model (111,131,141,151) communicate with each other; and a fluid feeding portion connecting portion that connects a fluid feeding portion for feeding a fluid into the inner cavities, characterized in that the biological model connecting portion (161J, 162J, 163Ja, 164J) comprises at least two or more of: a first connection portion for connecting a brain model simulating a brain; a second connection portion for connecting a heart model simulating a heart; a third connection portion for connecting a liver model simulating a liver; and a fourth connection portion for connecting a lower limb model simulating a lower limb. a biological model connecting portion (161J,162J,163Ja,164J) that attachably/detachably connects the biological model (110,110b,120,130,140,150,170) in a state where an inner cavity of the aorta model (160,160a) and an inner cavity of the partial blood vessel model (111,131,141,151) communicate with each other; and a fluid feeding portion connecting portion that connects a fluid feeding portion for feeding a fluid into the inner cavities, characterized in that the biological model connecting portion (161J, 162J, 163Ja, 164J) comprises at least two or more of: a first connection portion for connecting a brain model simulating a brain; a second connection portion for connecting a heart model simulating a heart; a third connection portion for connecting a liver model simulating a liver; and a fourth connection portion for connecting a lower limb model simulating a lower limb. a first connection portion for connecting a brain model simulating a brain; a second connection portion for connecting a heart model simulating a heart; a third connection portion for connecting a liver model simulating a liver; and a fourth connection portion for connecting a lower limb model simulating a lower limb.