A compound represented by Formula I, its enantiomers, diastereoisomers, tautomers, hydrates, solvates or a pharmaceutically acceptable salt thereof: wherein: R 1 is halogen, -CF 3 or -S n R 8; R 2 is optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 3 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 4 is optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 5 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 6 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 7 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 8 is hydrogen, CF 3 or optionally substituted C 1-8 alkyl; and n is 0, 1 or 2, wherein the optional substituent of an alkyl is selected from halogen atoms, hydroxyl groups, cycloalkyl groups, amino groups, heterocyclic groups, aryl groups, carboxylic acid groups, phosphonic acid groups, sulphonic acid groups, phosphoric acid groups, nitro groups, amide groups, sulfonamide groups, sulfate groups, sulfide groups, sulfonate groups, sulfoxide groups, phosphonate groups, phosphate groups, cyano groups, nitro groups, ether groups, ester groups, aldehyde groups and ketone groups; wherein the optional substituent of a cycloalkyl is selected from halogen atoms, sulfonyl C 1-8 alkyl groups, sulfoxide C 1-8 alkyl groups, sulfonamide groups, nitro groups, cyano groups, -OC 1-8 alkyl groups, -SC 1-8 alkyl groups, -C 1-8 alkyl groups, -C 2-6 alkenyl groups, - C 2-6 alkynyl groups, ketone groups, alkylamino groups, amino groups, aryl groups, C 3-8 cycloalkyl groups and hydroxyl groups; wherein the optional substituent of a cycloalkenyl is selected from halogen atoms, sulfonyl groups, sulfoxide groups, nitro groups, cyano groups, -OC 1-6 alkyl groups, -SC 1-6 alkyl groups, -C 1-6 alkyl groups, -C 2-6 alkenyl groups, - C 2-6 alkynyl groups, ketone groups, alkylamino groups, amino groups, aryl groups, C 3-8 cycloalkyl groups and hydroxyl groups; wherein the optional substituent of an alkenyl is selected from alkyl groups, and halogen atoms; wherein the optional substituent of a heterocycle is selected from halogen atoms, sulfonyl groups, sulfoxide groups, nitro groups, cyano groups, -OC 1-6 alkyl groups, -SC 1-6 alkyl groups, -C 1-8 alkyl groups, -C 2-6 alkenyl groups, - C 2-6 alkynyl groups, ketone groups, alkylamino groups, amino groups, aryl groups, C 3-8 cycloalkyl groups and hydroxyl groups; and wherein the optional substituent of an aryl is selected from halogen atoms, sulfonyl C 1-6 alkyl groups, sulfoxide C 1-6 alkyl groups, sulfonamide groups, carboxcyclic acid groups, C 1-6 alkyl carboxylates (ester) groups, amide groups, nitro groups, cyano groups, -OC 1-6 alkyl groups, -SC 1-6 alkyl groups, -C 1-6 alkyl groups, -C 2-6 alkenyl groups, - C 2-6 alkynyl groups, ketone groups, aldehydes, alkylamino groups, amino groups, aryl groups, C 3-8 cycloalkyl groups and hydroxyl groups. R 1 is halogen, -CF 3 or -S n R 8; R 2 is optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 3 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 4 is optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 5 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 6 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 7 is H, optionally substituted C 1-8 alkyl, optionally substituted C 3-8 cycloalkyl, optionally substituted heterocycle, optionally substituted C 6-10 aryl, optionally substituted C 3-8 cycloalkenyl; R 8 is hydrogen, CF 3 or optionally substituted C 1-8 alkyl; and n is 0, 1 or 2,