A pharmaceutical composition comprising a protein phosphatase 2A inhibitor and monosodium glutamate wherein the protein phosphatase 2A inhibitor has the structure wherein bond α is present or absent; R 1 and R 2 is each independently H, O- or OR 9, where R 9 is H, alkyl, alkenyl, alkynyl or aryl, or R 1 and R 2 together are =O; R 3 and R 4 are each different; R 3 is OH, O-, OR 9, SH, S-, SR 9, or where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R 11, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; R 4 is OH, O-, OR 9, SH, S-, SR 9, or where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R H, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; R 5 and R 6 is each independently H, OH, or R 5 and R 6 taken together are =O; and R 7 and R 8 is each independently H, F, Cl, Br, SO 2 Ph, CO 2 CH 3, or SR 12, where R 12 is H, aryl or a substituted or unsubstituted alkyl, alkenyl or alkynyl, or a salt, enantiomer or zwitterion of the compound, wherein the pH of the pharmaceutical composition is 10-11. bond α is present or absent; R 1 and R 2 is each independently H, O- or OR 9, where R 9 is H, alkyl, alkenyl, alkynyl or aryl, or R 1 and R 2 together are =O; R 3 and R 4 are each different; R 3 is OH, O-, OR 9, SH, S-, SR 9, or where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R 11, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; R 4 is OH, O-, OR 9, SH, S-, SR 9, or where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R H, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R 11, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R 11, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; R 4 is OH, O-, OR 9, SH, S-, SR 9, or where X is O, S, NR 10, or N + R 10 R 10, where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R H, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; where each R 10 is independently H, alkyl, substituted C 2 -C 12 alkyl, alkenyl, substituted C 4 -C 12 alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl where the substituent is other than chloro when R 1 and R 2 are =O, -CH 2 CN, -CH 2 CO 2 R H, -CH 2 COR 11, -NHR 11 or -NH + (R 11) 2, where each R 11 is independently alkyl, alkenyl or alkynyl, each of which is substituted or unsubstituted, or H; R 5 and R 6 is each independently H, OH, or R 5 and R 6 taken together are =O; and R 7 and R 8 is each independently H, F, Cl, Br, SO 2 Ph, CO 2 CH 3, or SR 12, where R 12 is H, aryl or a substituted or unsubstituted alkyl, alkenyl or alkynyl, or a salt, enantiomer or zwitterion of the compound, wherein the pH of the pharmaceutical composition is 10-11.