A compound of the formula in which R 1 is hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy, halogen-(C 1-8)alkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-a)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl, or (C 2-8)alkynyl; R 2 is an aryl, heteroaryl or non-aromatic heterocyclyl group G 1, which group G 1 is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, hydroxy, (C 1-8)alkoxy, halogen-(C 1-8)alkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-8)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl, (C 2-8)alkynyl and a (C 3-8)cycloalkyl, aryl, heteroaryl or non-aromatic heterocyclyl group G 2, which group G 2 is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, hydroxy, (C 1-8)alkoxy, halogen-(C 1-8)atkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-8)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl and (C 2-8)alkynyl; R 3 is hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy, halogen-(C 1-8)alkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-8)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl, or (C 2-8)alkynyl; either R 4 is hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy, halogen-(C 1-8)alkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-8)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl, or (C 2-8)alkynyl; and R 5 is hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy, halogen-(C 1-8)alkoxy, (C 1-8)alkylthio, halogen-(C 1-8)alkylthio, (C 1-8)alkoxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkoxy, (C 1-8)alkoxy-(C 1-8)alkylthio, (C 1-8)alkylthio-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkoxy, (C 1-8)alkylthio-(C 1-8)alkylthio, (C 2-8)alkenyl, or (C 2-8)alkynyl; or R 4 and R 5, taken together, are -C =C -C =C - or a (C 1-8)alkylene group, in which (C 1-8)alkylene group 1 or 2 -CH 2 - ring members are optionally replaced with hetero ring members independently selected from the group, consisting of -N -, -N[(C 1-8)alkyl]-, -O-, -S-, -S(=O)- or - S(=O) 2 -; R 6 is hydrogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, hydroxy-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkyl, mercapto-(C 1-8)alkyl, (C 1-8)alkylthio-(C 1-8)alkyl, amino-(C 1-8)alkyl, N-(C 1-8)alkylamino-(C 1-8)alkyl, N,N-di-[(C 1-8)alkyl]amino-(C 1-8)alkyl with two identical or different (C 1-8)alkyl moieties in the N,N-di-[(C 1-8)alkyl]amino moiety, (C 2-8)alkenyl, or (C 2-8)alkynyl; E 1 is -C(R 7)(R 8)- or -C(R 7)(R 8)-C(R 9)(R 10)-; E 2 is -C(R 11)(R 12)- or -C(R 11) (R 12)-C(R 13)(R 14)-; either each of R 7 and R 8 is independently selected from the group, consisting of hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkyl and (C 1-8)alkylthio-(C 1-8)alkyl; or R 7 and R 8, taken together, are oxo or -CH 2 -CH 2 -; either each of R 9 and R 10 is independently selected from the group, consisting of hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkyl and (C 1-8)alkylthio-(C 1-8)alkyl; or R 9 and R 10, taken together, are oxo or -CH 2 -CH 2 -; either each of R 11 and R 12 is independently selected from the group, consisting of hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkyl and (C 1-8)alkylthio-(C 1-8)alkyl; or R 11 and R 12, taken together, are oxo or -CH 2 -CH 2 -; and either each of R 13 and R 14 is independently selected from the group, consisting of hydrogen, cyano, halogen, (C 1-8)alkyl, halogen-(C 1-8)alkyl, (C 1-8)alkoxy-(C 1-8)alkyl and (C 1-8)alkylthio-(C 1-8)alkyl; or R 13 and R 14, taken together, are oxo or -CH 2 -CH 2 -, in free form or in salt form.