mhurhangee/ep-ind-claims huggingface dataset:
A compound with the structure of Formula I: wherein R6-R10 and R6'-R9' are independently selected from at least one of hydrogen, hydroxyl, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, -N(C 1-3 alkyl)2, -NH(C 1-3 alkyl), -C(=O)NH 2,-C(=O)NH(C 1-3 alkyl), -C(=O)N(C 1-3 alkyl)2, -S(=O) 2 (C 1-3 alkyl), -S(=O) 2 NH 2, -S(=O) 2 N(C 1-3 alkyl)2, -S(=O) 2 NH(C 1-3 alkyl), -CHF 2, -OCF 3, -OCHF 2, -SCF 3, -CF 3, -CN, -NH 2, and -NO 2; R20 is optionally substituted aryl or heteroaryl; and R21 is optionally substituted heteroaryl; or a pharmaceutically-acceptable salt thereof, for use in a method of treating a neurodegenerative disease or disorder associated with compromised axonal function selected from Charcot-Marie-Tooth Disease 2, spinal muscular atrophy, hereditary sensory motor neuropathy, hereditary spastic paraplegia, and multiple sclerosis in a human patient. wherein R6-R10 and R6'-R9' are independently selected from at least one of hydrogen, hydroxyl, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, -N(C 1-3 alkyl)2, -NH(C 1-3 alkyl), -C(=O)NH 2,-C(=O)NH(C 1-3 alkyl), -C(=O)N(C 1-3 alkyl)2, -S(=O) 2 (C 1-3 alkyl), -S(=O) 2 NH 2, -S(=O) 2 N(C 1-3 alkyl)2, -S(=O) 2 NH(C 1-3 alkyl), -CHF 2, -OCF 3, -OCHF 2, -SCF 3, -CF 3, -CN, -NH 2, and -NO 2; R20 is optionally substituted aryl or heteroaryl; and R21 is optionally substituted heteroaryl; or a pharmaceutically-acceptable salt thereof, for use in a method of treating a neurodegenerative disease or disorder associated with compromised axonal function selected from Charcot-Marie-Tooth Disease 2, spinal muscular atrophy, hereditary sensory motor neuropathy, hereditary spastic paraplegia, and multiple sclerosis in a human patient.
A communication controller for exchanging data on first and second independent communication channels, the communication controller configured such that, in a first mode, data transmitted on the first communication channel cannot be decoded on the second communication channel, and, in a second mode, data transmitted on the first communication channel is decodable on the second communication channel so as to provide loop back functionality, characterized in that the data comprises data frames and each data frame include a portion which comprises a cyclic redundancy code, and wherein the cyclic redundancy codes for the first and second communication channels are generated in dependence upon a first and second constants wherein, in the first mode, the first and second constants are different and, in the second, the first and second constants are the same.
An airbag system for a saddle-ride type vehicle comprising an airbag to be inflated and deployed upward from the vehicle in front of a rider, wherein the airbag is provided with a part opposite to a head opposite to a rider's head (Mh) when inflated and deployed, and a neck part which rises upward from the vehicle and toward the part opposite to the head, wherein the width of the neck part is smaller than the width of the part opposite to the head, and wherein the neck part has a necking curved inside in the direction of vehicle width; characterized in that an upper part (30h2) of the part opposite to the head is wider than a lower part (30h1) of the part opposite to the head when the airbag is inflated and deployed, and in that the part opposite to the head is arranged so that it is entirely located in front of the handlebar provided on the vehicle when the airbag is inflated and deployed.
A bispecific antibody comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and the two Fab fragments are connected to each other by two peptide linkers comprising the amino acid sequence of (GxS)n or (GxS)nGm with G = glycine, S = serine and (x = 3, n= 3, 4, 5 or 6, and m= 0, 1, 2 or 3) or (x = 4,n= 2, 3, 4 or 5 and m= 0, 1, 2 or 3), wherein (i) the first Fab fragment is connected to the N-terminus of the second Fab fragment by the two peptide linkers, or (ii) the first Fab fragment is connected to the C-terminus of the second Fab fragment by the two peptide linkers, and wherein the bispecific antibody is devoid of a Fc domain.
Method for determining the absolute position of a mobile unit, which has at least one optical surroundings sensor that captures a detection area of the environment of the mobile unit, in a predefined navigation environment, wherein optically, distinguishable markers (15, 18) that can be detected by the surroundings sensor are used in the navigation environment, which are each assigned an absolute position that is retrievable from a map dataset, wherein for position determination, at least one marker (15, 18) is detected and identified, by means of an image processing algorithm, in sensor data recorded by at least one of the at least one surroundings sensors, and a relative position between the mobile unit and the marker (15, 18) is determined taking account of the position of the marker (15, 18) in the sensor data, and an absolute position of the mobile unit is determined as a function of the relative position and the absolute position of the marker (15, 18), wherein adjustment data are determined using the map dataset which describe the markers (15, 18) that can be captured by the surroundings sensors at the current point in time and their position relative to the mobile unit, taking into account the last position of the mobile unit determined taking account of the marker (15,18), and are used to limit the sensor data recorded by the surrounding sensors available at the current point in time, which are to be evaluated in order to detect and identify one of the currently distinguishable markers (15, 18), wherein as limitation, only one extract of an image contained in the sensor data in which a marker (15, 18) is expected is evaluated, characterised in that the map dataset contains information about potential visual obstacles which is taken into account when determining the adjustment data.
A printing apparatus for printing seamless cans comprising a mandrel wheel that revolves intermittently, a plurality of mandrels that can rotate on their axes while the mandrel wheel is at a halt and are provided on the mandrel wheel, and ink-jet printing stations (W, C, M, Y, K) for ink-jet printing images on at least the can walls on the outer surfaces of seamless cans fitted onto the mandrels, characterized in that the ink-jet printing is executed in a plurality of ink-jet printing stations (W, C, M, Y, K), each ink-jet printing station has a plurality of ink-jet heads containing an ink of the same color, the plurality of ink-jet heads are arranged on the outer circumferential side of the mandrel wheel in each ink-jet printing station (W, C, M, Y, K), and ejection ports of the plurality of ink-jet heads are all formed being directed downward or being directed downward and tilted, and a false-curing station and a finishing varnish coating station are successively provided at positions on the downstream of the ink-jet printing stations (W, C, M, Y, K).
A pipe comprising a first tubular material, a second tubular material and a third tubular material; wherein an end of the second tubular material (12;32;52) and an end of the third tubular material (13;33;53), which is located adjacent to the second tubular material, are joined by butt welding to form a piping joint structure, wherein an inner fitting portion (14a;34a;54a) that fits the inside of one end of the third tubular material, is formed around the circumference on the end of said second tubular material (12;32;52); a first bevel (14b;34b;54b) is formed on the radial outside of said inner fitting portion around the circumference; an outer fitting portion (15a;35a), which is fitted to the radial outside of said inner fitting portion, is formed on the end of said third tubular material (13;33;53); a second bevel (15b;35b;B) is formed at the end of said outer fitting portion around the circumference at a location that is at the end face of said third tubular material (13;33;53) and that faces said first bevel; the inner diameter and the outer diameter of the third tubular member are substantially the same as the inner diameter and the outer diameter of the first tubular member; the shape of the cross-section of the face of said inner fitting portion (14a;34a;54a) located on the radial outside, and the shape of the cross-section of the face of said outer fitting portion located on the radial inside, are processed such that each is completely round with a curvature that is constant around the whole circumference; the pipe being characterized in that a thickness of the second tubular material increases gradually from one end side toward the other side in which the inner fitting portion is formed, due to a gradual decrease in inner diameter from said one end side toward said other side, the outer diameter of the second tubular material maintaining substantially the same measurement as the outer diameter of the first tubular material; and a difference (C1-C2) between a diameter of a surface located on the radial outside of said inner fitting portion (14a;34a;54a) and a diameter of a surface located on the radial inside of said outer fitting portion (15a;35a), is between 1.0 mm to 1.6 mm.
A system (10, 110, 210) for establishing an intervehicle communication for at least a first and a second commercial vehicles, comprising at least one physical communication line (16, 17, 116, 117, 216, 217), wherein the communication line (16, 17, 116, 117, 216, 217) is bidirectional, wherein at one point of the communication line (16, 17, 116, 117, 216, 217) a first authentication code generation module (18, 118, 218) is provided, which is dedicated to the first commercial vehicle, wherein at another point of the communication line (16, 17, 116, 117, 216, 217) a second code processing module (20, 120, 220) is provided, which is dedicated to the second commercial vehicle, wherein the first authentication code generation module (18, 118, 218) is configured to send identification information and/or authentication information and encryption keys and wherein the second code processing module (20, 120, 220) is configured to process and send back identification information and/or authentication information and encryption keys, especially processed and/or modified identification information and/or authentication information and encryption keys, wherein the communication line is a pneumatic line, wherein the first authentication code generation module and the second code processing module are configured and arranged such that the identification information and/or authentication information and encryption keys are transmitted by at least one pressure signal and/or a series of pressure signals, which correspond(s) to and/or represent(s) the identification information and/or authentication information and encryption keys.
A composite material comprising a substrate composed of resin and a graphene or lamina graphite carbon material layer provided so as to cover at least part of the surface of the substrate, wherein graphene or lamina graphite carbon is closely attached to the surface of the substrate, wherein the substrate composed of resin is fine resin particles with an average diameter of 200 μm or less and the graphene or lamina graphite carbon material layer is formed so as to cover the outer surface of the fine resin particles with the average diameter of 200 μm or less, wherein some of the graphene or lamina graphite carbon penetrates the substrate from the surface of the substrate toward the inner part.
A platform screen door system comprising a plurality of fixed panels (3,4) and a plurality of sliding door panels (1,2), which sliding door panels have a proximal side to the fixed panels (3,4) and a distal side remote from the fixed panel, the system further comprising a header structure (5,6) for receiving at least part of a door driving means, the sliding door panels being supported by a frame, characterised in that the frame at distal side has a greater thickness than the frame at the proximal side.
Dishwasher, in particular domestic dishwasher, with a support module and with a base part of a dishwasher cavity, which can be interconnected in first connection regions, in particular on the front side of the appliance, with the aid of fixed bearings and in second connection regions spaced apart therefrom in the depth direction (y) of the dishwasher, in particular on the rear side of the appliance, characterised in that the support module and the base part of the dishwasher cavity are interconnected in the second connection regions to compensate for component tolerances of the support module and/or the base part of the dishwasher cavity with the aid of tolerance compensation elements, wherein the tolerance compensation elements - are fastened to the support module or to the base part and - in each case have at least one first toothed bar contour, which in each case is in engagement with at least one second toothed bar contour which corresponds thereto and is arranged on the base part or on the support module, and brings about a form-fit connection acting in the depth direction (y), in order to transmit forces acting in or against the depth direction (y). - are fastened to the support module or to the base part and - in each case have at least one first toothed bar contour, which in each case is in engagement with at least one second toothed bar contour which corresponds thereto and is arranged on the base part or on the support module, and brings about a form-fit connection acting in the depth direction (y), in order to transmit forces acting in or against the depth direction (y).
Structure having two concrete components (10, 20), a construction joint between the concrete components (10, 20), and a joint sheet for sealing off the construction joint, wherein the joint sheet is composed of or comprises an elongate plate which is installed along the construction joint, and so as to bridge the latter transversely, with anchoring depths (E1, E2) in both concrete components (10, 20), characterized in that the anchoring depths (E1, E2) correspond at least to anchoring depths (E1', E2') that must be adhered to as a minimum, and in that the plate is, along these anchoring depths (E1', E2') that must be adhered to as a minimum, provided with a marking (32, 33) which is in each case suitable for indicating said anchoring depths.
A method of preparing a composition, comprising the steps of: (a) providing a mixture of carbon particles and a solvent and shearing the mixture to form a dispersion of the carbon particles in the solvent; and (b) adding non-fibrillated poly(tetraflouroethylene) to the dispersion to provide a resultant mixture and shearing the resultant mixture until at least a portion of the poly(tetrafluoroethylene) has been fibrillated, the method being operated at room temperature. (a) providing a mixture of carbon particles and a solvent and shearing the mixture to form a dispersion of the carbon particles in the solvent; and (b) adding non-fibrillated poly(tetraflouroethylene) to the dispersion to provide a resultant mixture and shearing the resultant mixture until at least a portion of the poly(tetrafluoroethylene) has been fibrillated, the method being operated at room temperature.
An antibody that specifically binds to an epitope in the second extracellular loop of EMP2 wherein the epitope comprises the amino acid sequence DIHDKNAKFYPVTREGSYG for use in the treatment of breast cancer wherein the breast cancer comprises a triple negative breast cancer tumor.
A medicament for use in treating gout, characterized in that the medicament comprises by weight content, 1-99 portions of a marine algal glycoprotein, 8-14 portions of indigo naturalis, and 7-13 portions of twotooth achyranthes root.
A method for the determination of the oxidative stability of a lubricating fluid, comprising the steps of: measuring the viscosity of the lubricating fluid before the oxidation has been performed introducing a sample of the lubricating fluid under test in an reaction cell; introducing catalytic amounts of a catalyst to the reaction cell; heating the cell to the oxidation temperature of the lubricating fluid and maintaining this temperature; delivering a gas comprising oxygen at constant flow rate through the cell over the course of the reaction; delivering a gas comprising nitrogen dioxide at a constant flow rate through the cell for a specified time; applying and maintaining a specified vacuum on the reaction cell; allowing the mixture to react for a specified time; measuring the viscosity of the oxidized lubricating fluid; and determining the increase in the viscosity. measuring the viscosity of the lubricating fluid before the oxidation has been performed introducing a sample of the lubricating fluid under test in an reaction cell; introducing catalytic amounts of a catalyst to the reaction cell; heating the cell to the oxidation temperature of the lubricating fluid and maintaining this temperature; delivering a gas comprising oxygen at constant flow rate through the cell over the course of the reaction; delivering a gas comprising nitrogen dioxide at a constant flow rate through the cell for a specified time; applying and maintaining a specified vacuum on the reaction cell; allowing the mixture to react for a specified time; measuring the viscosity of the oxidized lubricating fluid; and determining the increase in the viscosity.
A composition comprising a preformed calcium ceramic granule having a specific surface area greater than 30 m 2 /g and having an interconnected network of micropores defining at least one surface on an interior of the granule; and a bone morphogenic protein associated with the at least one interior surface wherein the BMP is distributed on the interior surface of the granule including on a portion of the interior surface located within a radius of approximately 20% of the average distance from the centroid to the outer surface of the granule, wherein a concentration of the BMP located within a radius of approximately 20% of the average distance from the centroid to the outer surface of the granule is not less than about 33% of a concentration of the osteoinductive protein on the external surface of the granule.
A liquid polymeric phosphite which comprises: wherein each R 1, R 2, R 3 and R 4 can be the same or different and independently selected from the group consisting of C 1-20 alkyl, C 3-22 alkenyl, C 6-40 cycloalkyl, C 7-40 cycloalkylene, C 1-20 methoxy alkyl glycol ethers, C 1-20 alkyl glycol ethers, and/or Y-OH; Y is an ethylene or propylene group; m is an integral value such that when Y is an ethylene group a polyethylene glycol of formula H[O-Y] m -OH has a molecular weight 300 to 400, and when Y is a propylene group a polypropylene glycol of formula H[O-Y] m -OH has a molecular weight of 300 to 1000; and x is an integral value ranging from 1 to 1,000. each R 1, R 2, R 3 and R 4 can be the same or different and independently selected from the group consisting of C 1-20 alkyl, C 3-22 alkenyl, C 6-40 cycloalkyl, C 7-40 cycloalkylene, C 1-20 methoxy alkyl glycol ethers, C 1-20 alkyl glycol ethers, and/or Y-OH; Y is an ethylene or propylene group; m is an integral value such that when Y is an ethylene group a polyethylene glycol of formula H[O-Y] m -OH has a molecular weight 300 to 400, and when Y is a propylene group a polypropylene glycol of formula H[O-Y] m -OH has a molecular weight of 300 to 1000; and x is an integral value ranging from 1 to 1,000.
A method for applying a resin finish to a pool surface, the method comprising: preparing the pool surface; applying an epoxy layer to the pool surface; hot flocking a first coat of the resin finish onto the epoxy layer prior to curing the epoxy layer so that the first coat of the resin finish integrates with the epoxy layer such that the epoxy layer and the first coat of resin finish merge, wherein the merged layer acts as a barrier to the pool surface acting as a heat sink; allowing the merged layer to cure; heating the surface of the cured merged layer until the first coat of resin finish contained therewithin becomes glossy; and applying a second coat of the resin finish onto the glossy cured merged layer, wherein the hot flocking a first coat of the resin finish, the heating of the cured merged layer, and the applying a second coat of the resin finish include heating the resin finish until it becomes a liquid, wherein the resin finish becomes a liquid at temperatures below approximately 100°C. preparing the pool surface; applying an epoxy layer to the pool surface; hot flocking a first coat of the resin finish onto the epoxy layer prior to curing the epoxy layer so that the first coat of the resin finish integrates with the epoxy layer such that the epoxy layer and the first coat of resin finish merge, wherein the merged layer acts as a barrier to the pool surface acting as a heat sink; allowing the merged layer to cure; heating the surface of the cured merged layer until the first coat of resin finish contained therewithin becomes glossy; and applying a second coat of the resin finish onto the glossy cured merged layer,
A processor comprising: a plurality of cores each to independently execute instructions; a power delivery logic coupled to the plurality of cores; and a power controller including a first logic that in response to a power consumption level of the processor being greater than a threshold level is to cause a first core of the plurality of cores to enter into a first inactive low power state of an operating system power management, OSPM, scheme independently of the OS, during execution of at least one thread on the first core and without a request from the first core, wherein the first logic is to send a first low power force signal to the first core to cause the first core to prepare for entry into the first inactive low power state during the at least one thread execution, and to send a second low power force signal to the power delivery logic to cause the power delivery logic to turn off power to the first core after the first core is prepared for the entry, a plurality of cores each to independently execute instructions; a power delivery logic coupled to the plurality of cores; and a power controller including a first logic that in response to a power consumption level of the processor being greater than a threshold level is to cause a first core of the plurality of cores to enter into a first inactive low power state of an operating system power management, OSPM, scheme independently of the OS, during execution of at least one thread on the first core and without a request from the first core, wherein the first logic is to send a first low power force signal to the first core to cause the first core to prepare for entry into the first inactive low power state during the at least one thread execution, and to send a second low power force signal to the power delivery logic to cause the power delivery logic to turn off power to the first core after the first core is prepared for the entry,