mhurhangee/ep-ind-claims huggingface dataset:
A method of screening a test compound for the ability to bind and stabilize a target peptide by binding of the test compound to a binding site of the target peptide in a cell, comprising: (a) providing in the cell a fusion protein comprising (i) the target peptide having a destabilizing mutation, which comprises an amino acid deletion or substitution and which destabilizes the peptide as compared to the non-mutated peptide and (ii) an enzyme fragment for detection; (b) incubating a mixture of the cell of (a) and the test compound for a period sufficient to allow binding of the test compound to the binding site of the target peptide and to allow for stabilization of the fusion protein by the binding; (c) combining the mixture from step (b) with a label that detects an amount of the enzyme fragment remaining after incubating, wherein an increase in the amount of enzyme fragment detected identifies the test compound as having the ability to stabilize the target peptide by binding to the target peptide. (a) providing in the cell a fusion protein comprising (i) the target peptide having a destabilizing mutation, which comprises an amino acid deletion or substitution and which destabilizes the peptide as compared to the non-mutated peptide and (ii) an enzyme fragment for detection; (b) incubating a mixture of the cell of (a) and the test compound for a period sufficient to allow binding of the test compound to the binding site of the target peptide and to allow for stabilization of the fusion protein by the binding; (c) combining the mixture from step (b) with a label that detects an amount of the enzyme fragment remaining after incubating, wherein an increase in the amount of enzyme fragment detected identifies the test compound as having the ability to stabilize the target peptide by binding to the target peptide.
A powered nailer, comprising: a power source including a driving element reciprocating within a cylinder between a prefiring position and a fastener driving position, the driving element being in the fastener driving position when the element engages a bumper disposed at the bottom of the cylinder; a reciprocating valve element defining a combustion chamber in fluid communication with said cylinder and configured for receiving a dose of fuel and air prior to a user-generated ignition; and a return chamber in fluid communication with said cylinder through openings in the cylinder, said return chamber being configured for receiving a supply of pressurized air generated by said driving element as it moves from the prefiring position to the fastener driving position, said pressurized air passing through said openings, said openings being further configured for allowing the pressurized air to return from the return chamber to the cylinder so as to act on an underside of said driving element for returning it to the pre-firing position, characterised in that said combustion chamber is configured open to atmosphere upon said driving element reaching said bumper. a power source including a driving element reciprocating within a cylinder between a prefiring position and a fastener driving position, the driving element being in the fastener driving position when the element engages a bumper disposed at the bottom of the cylinder; a reciprocating valve element defining a combustion chamber in fluid communication with said cylinder and configured for receiving a dose of fuel and air prior to a user-generated ignition; and a return chamber in fluid communication with said cylinder through openings in the cylinder, said return chamber being configured for receiving a supply of pressurized air generated by said driving element as it moves from the prefiring position to the fastener driving position, said pressurized air passing through said openings, said openings being further configured for allowing the pressurized air to return from the return chamber to the cylinder so as to act on an underside of said driving element for returning it to the pre-firing position, characterised in that said combustion chamber is configured open to atmosphere upon said driving element reaching said bumper.
A vehicle having a vehicle-mounted speaker system, the vehicle-mounted speaker system comprising: a supporting member that is disposed between a vehicle interior space and a vehicle exterior space, the vehicle exterior space being an inside space of a door, which is a space into which water droplets and dust may enter through a clearance for window glass, or an engine room, to separate the vehicle interior space from the vehicle exterior space, and that is provided with an opening through which the vehicle interior space is configured to communicate with the vehicle exterior space; a speaker that is supported by the supporting member in such a manner as to oppose the opening; and a rear cover that closes the opening so as to define an enclosed space between the rear cover and the speaker, wherein the rear cover is exposed to the vehicle exterior space; characterized in that the rear cover includes an annular flexible member bended in cross section supported by the supporting member, and a non-flexible vibrating plate which is supported by an inner portion of the annular flexible member and whose pressure receiving area is larger than a pressure receiving area of the annular flexible member. a supporting member that is disposed between a vehicle interior space and a vehicle exterior space, the vehicle exterior space being an inside space of a door, which is a space into which water droplets and dust may enter through a clearance for window glass, or an engine room, to separate the vehicle interior space from the vehicle exterior space, and that is provided with an opening through which the vehicle interior space is configured to communicate with the vehicle exterior space; a speaker that is supported by the supporting member in such a manner as to oppose the opening; and a rear cover that closes the opening so as to define an enclosed space between the rear cover and the speaker, wherein the rear cover is exposed to the vehicle exterior space; characterized in that the rear cover includes an annular flexible member bended in cross section supported by the supporting member, and a non-flexible vibrating plate which is supported by an inner portion of the annular flexible member and whose pressure receiving area is larger than a pressure receiving area of the annular flexible member.
A medical waste collection system for collecting medical waste material through a manifold during a medical procedure, the medical waste collection system comprising: a waste container (106, 108); a vacuum source configured to provide a vacuum on said waste container (106, 108); a receiver coupled to said waste container (106, 108) and comprising: a housing (268, 366) comprising an opening into which the manifold is configured to be inserted, said housing (268, 366) further comprising a receiver outlet; and an inlet mechanism coupled to said housing (268, 366) so as to be movable in proximal and distal directions, wherein said inlet mechanism comprises a suction inlet, and a suction outlet in fluid communication with said suction inlet; characterized in that the medical waste collection system further comprises: a sled assembly movably coupled to said housing (268, 366) and operably coupled to said inlet mechanism, wherein said sled assembly is configured to be moved in a proximal direction during insertion of the manifold into said receiver in the proximal direction to facilitate said inlet mechanism moving correspondingly in the distal direction to establish fluid communication between said suction outlet and said receiver outlet. a waste container (106, 108); a vacuum source configured to provide a vacuum on said waste container (106, 108); a receiver coupled to said waste container (106, 108) and comprising: a housing (268, 366) comprising an opening into which the manifold is configured to be inserted, said housing (268, 366) further comprising a receiver outlet; and an inlet mechanism coupled to said housing (268, 366) so as to be movable in proximal and distal directions, wherein said inlet mechanism comprises a suction inlet, and a suction outlet in fluid communication a housing (268, 366) comprising an opening into which the manifold is configured to be inserted, said housing (268, 366) further comprising a receiver outlet; and an inlet mechanism coupled to said housing (268, 366) so as to be movable in proximal and distal directions, wherein said inlet mechanism comprises a suction inlet, and a suction outlet in fluid communication with said suction inlet;
A one-part urethane adhesive composition comprising a urethane prepolymer comprising an isocyanate group; an isocyanurate compound comprising an isocyanurate ring; and a terpene compound comprising an active hydrogen. a urethane prepolymer comprising an isocyanate group; an isocyanurate compound comprising an isocyanurate ring; and a terpene compound comprising an active hydrogen.
Saw, in particular mitre saw, comprising a sawing apparatus, which has a saw blade drivable by a drive motor and which is located on a swivel support mounted on an oblique swivel base for oblique swivelling about a horizontal oblique swivel axis, wherein the saw comprises an oblique swivel transmission for adjusting an oblique swivel position of the sawing apparatus relative to the oblique swivel base, wherein the oblique swivel transmission is located on a rear side of the saw and comprises an operating device for manual operation, which projects to a front side of the saw, so that the oblique swivel transmission can be operated from the front, and wherein the sawing apparatus is located on a saw carriage for performing linear cuts on a workpiece, characterised in that the saw carriage is guided in a linear motion on a linear guide along a linear guide axis, which linear guide is located on the swivel support, and in that the operating device is located on the linear guide.
A surgical irrigation cassette comprising: a substantially rigid cassette housing defining a chamber therein; a liquid transfer portion of a pump including an intake side of the pump and an output side of the pump; and a plurality of fluid pathways (27, 32, 33, 37) disposed at least in part within the chamber, the fluid pathways including: a first fluid pathway including a first end connected with the intake side of the pump, and a second end for connecting with a supply fluid container; a second fluid pathway including a first end connected with the output side of the pump, and a second end for connecting with a handpiece; and a third fluid pathway including a first end for connecting with the handpiece, and a second end for connecting with a waste container; characterized in that the housing further defines first console connector including a first pneumatic connector port, and the plurality of fluid pathways (27, 32, 33, 37) further includes a fourth fluid pathway including a first end connected with the first console connector and a second end for connecting with the waste container. a substantially rigid cassette housing defining a chamber therein; a liquid transfer portion of a pump including an intake side of the pump and an output side of the pump; and a plurality of fluid pathways (27, 32, 33, 37) disposed at least in part within the chamber, the fluid pathways including: a first fluid pathway including a first end connected with the intake side of the pump, and a second end for connecting with a supply fluid container; a second fluid pathway including a first end connected with the output side of the pump, and a second end for connecting with a handpiece; and a third fluid pathway including a first end for connecting with the handpiece, and a second end for connecting with a waste container; characterized in that a first fluid pathway including a first end connected with the intake side of the pump, and a second end for connecting with a supply fluid container; a second fluid pathway including a first end connected with the output side of the pump, and a second end for connecting with a handpiece; and a third fluid pathway including a first end for connecting with the handpiece, and a second end for connecting with a waste container; characterized in that the housing further defines first console connector including a first pneumatic connector port, and the plurality of fluid pathways (27, 32, 33, 37) further includes a fourth fluid pathway including a first end connected with the first console connector and a second end for connecting with the waste container.
A method for verifying segment integrity and authenticity for adaptive streaming, the method comprising: receiving, at a user equipment, a segment of a media stream, wherein the media stream comprises a plurality of segments of a dynamic adaptive streaming over hypertext transfer protocol (DASH) stream; determining, with the UE, a digest or digital signature for the segment of the media stream; comparing, with the UE, the digest or digital signature to a correct digest or correct digital signature; and determining, with the UE, whether the segment has been modified; wherein the correct digest or the correct digital signature is obtained through a URL indicated in a media presentation description. receiving, at a user equipment, a segment of a media stream, wherein the media stream comprises a plurality of segments of a dynamic adaptive streaming over hypertext transfer protocol (DASH) stream; determining, with the UE, a digest or digital signature for the segment of the media stream; comparing, with the UE, the digest or digital signature to a correct digest or correct digital signature; and determining, with the UE, whether the segment has been modified; wherein the correct digest or the correct digital signature is obtained through a URL indicated in a media presentation description.
A method for wireless communications by a user equipment, UE, comprising: receiving an uplink grant indicating one or more tones within a resource block, RB, allocated to the UE for narrowband communication, wherein the uplink grant indicates the one or more tones for narrowband communication using a scheduling unit size of at least one of: a single tone, three tones, six tones, or twelve tones; wherein the indication is provided via a set of bits; different values of the set of bits indicate different combinations of one or more contiguous tones within the RB; and the different combinations are based on the scheduling unit size; wherein: a first set of the different values indicate different combinations of one or more contiguous tones; a second set of the different values indicate a single tone allocation; a third set of the different values indicates non-contiguous tone allocation; and transmitting using the one or more tones indicated in the uplink grant. receiving an uplink grant indicating one or more tones within a resource block, RB, allocated to the UE for narrowband communication, wherein the uplink grant indicates the one or more tones for narrowband communication using a scheduling unit size of at least one of: a single tone, three tones, six tones, or twelve tones; wherein the indication is provided via a set of bits; different values of the set of bits indicate different combinations of one or more contiguous tones within the RB; and the different combinations are based on the scheduling unit size; wherein: a first set of the different values indicate different combinations of one or more contiguous tones; a second set of the different values indicate a single tone allocation; a third set of the different values indicates non-contiguous tone allocation; and transmitting using the one or more tones indicated in the uplink grant. a first set of the different values indicate different combinations of one or more contiguous tones; a second set of the different values indicate a single tone allocation; a third set of the different values indicates non-contiguous tone allocation; and transmitting using the one or more tones indicated in the uplink grant.
Tool half for an injection moulding machine for producing an injection moulded part with at least one insert part, comprising - a mould region, which forms at least part of a cavity for the injection moulded part; - a transport channel extending inside the tool half and through the mould region; - a feed channel, which is designed to feed the insert part into the tool half, extends vertically through the tool half and leads into a take-up region of the transport channel; - a positioning unit, which is designed, by virtue of a movement from a demoulding position into an injecting position, to take up the insert part when said insert part is arranged in the take-up region of the transport channel, and to transport the taken-up insert part from the take-up region to an injection moulding position in the region of the mould region; - a sensor system, which is designed to determine a position of the insert part and/or of the positioning unit and to transmit corresponding position signals to a controller of the tool half, which controller is configured to actuate the positioning unit for the purpose of transporting the insert part into the injection moulding position in dependence on the sensor signals. - a mould region, which forms at least part of a cavity for the injection moulded part; - a transport channel extending inside the tool half and through the mould region; - a feed channel, which is designed to feed the insert part into the tool half, extends vertically through the tool half and leads into a take-up region of the transport channel; - a positioning unit, which is designed, by virtue of a movement from a demoulding position into an injecting position, to take up the insert part when said insert part is arranged in the take-up region of the transport channel, and to transport the taken-up insert part from the take-up region to an injection moulding position in the region of the mould region; - a sensor system, which is designed to determine a position of the insert part and/or of the positioning unit and to transmit corresponding position signals to a controller of the tool half, which controller is configured to actuate the positioning unit for the purpose of transporting the insert part into the injection moulding position in dependence on the sensor signals.
A method for operating a system with a first automatically moving floor processing device and a second automatically moving floor processing device, wherein the first floor processing device detects environmental features in an environment of the first floor processing device, wherein the first floor processing device and the second floor processing device comprise data communication means by means of which the floor processing devices (1, 2) communicate with each other, wherein the first floor processing device or a shared computing device allocated to both the first floor processing device and the second floor processing device generates a first area map based on the detected environmental features, and wherein the first floor processing device also detects the second floor processing device, and the position of the second floor processing device is thereupon stored within the generated first area map, characterized in that the first floor processing device transmits its first area map created up to that point to the second floor processing device, and wherein the second floor processing device receives the first area map and information about a current position of the second floor processing device within the first area map already during a first floor processing activity performed by the first floor processing device, and wherein a control device of the second floor processing device controls a second floor processing activity independently on the basis of the first area map and the received information about the current position of the second floor processing device within the first area map.
A circuit comprising: first and second current control sub-circuits connected in series between a DC supply voltage node and a reference voltage node; third and fourth current control sub-circuits connected in series between the DC supply voltage node and the reference voltage node; characterised by a DC/DC converter with a first input terminal coupled to a first load node between the first and the second current control sub-circuit, a second input terminal coupled to a second load node between the third and the fourth current control sub-circuits, a first output terminal, and a second output terminal,; a plurality of pairs of output electrodes; a routing sub-circuit for selectively coupling each of the pairs of output electrodes to the first and the second output terminals; and a controller configured for operating the routing sub-circuit and the first, the second, the third, and the fourth current control sub-circuits to cause the DC/DC converter to supply a series of biphasic pulses at different ones of the plurality of pairs of output electrodes at different times. first and second current control sub-circuits connected in series between a DC supply voltage node and a reference voltage node; third and fourth current control sub-circuits connected in series between the DC supply voltage node and the reference voltage node; characterised by a DC/DC converter with a first input terminal coupled to a first load node between the first and the second current control sub-circuit, a second input terminal coupled to a second load node between the third and the fourth current control sub-circuits, a first output terminal, and a second output terminal,; a plurality of pairs of output electrodes; a routing sub-circuit for selectively coupling each of the pairs of output electrodes to the first and the second output terminals; and a controller configured for operating the routing sub-circuit and the first, the second, the third, and the fourth current control sub-circuits to cause the DC/DC converter to supply a series of biphasic pulses at different ones of the plurality of pairs of output electrodes at different times.
A corrosion inhibitor composition for inhibiting corrosion of iron and iron alloys, the corrosion inhibitor composition comprising: an effective amount of a naphthalene-1-thiocarboxamide dissolved in an organic solvent, wherein the effective amount of the corrosion inhibitor composition introduced into an environment is in the range from 0.01 to 5000 parts per million by volume.
An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body, and formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, characterised in that the apparatus further comprises: flow control wells formed in the surface of the body between the sensor wells, wherein the cross-sectional area of each flow control well is less than the cross-sectional area of each sensor well. a body, and formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, characterised in that the apparatus further comprises: flow control wells formed in the surface of the body between the sensor wells, wherein the cross-sectional area of each flow control well is less than the cross-sectional area of each sensor well. flow control wells formed in the surface of the body between the sensor wells, wherein the cross-sectional area of each flow control well is less than the cross-sectional area of each sensor well.