A compound of Formula: wherein: A is H; E is SO 2; X is Cl, Br, I, or OSO 2 R; Y is Cl, Br, I, or OSO 2 R; each R is independently H or C1-C6 alkyl; G is a radical selected from the group comprising Formulae -: wherein: R 1 is H, C1-C6 alkyl, CH 2 (CH 2) n OH, CH 2 CH CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 4 is N(R 6)(R 7), OH, OCH 2 (CH 2) n N(R 6)(R 7), or CH 2 (CH 2) n N(R 6)(R 7); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2, O, S, SO, or SO 2; n is 0 to 6; * represents a point of attachment to Formula; or a pharmaceutically acceptable salt thereof. A is H; E is SO 2; X is Cl, Br, I, or OSO 2 R; Y is Cl, Br, I, or OSO 2 R; each R is independently H or C1-C6 alkyl; G is a radical selected from the group comprising Formulae -: wherein: R 1 is H, C1-C6 alkyl, CH 2 (CH 2) n OH, CH 2 CH CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 4 is N(R 6)(R 7), OH, OCH 2 (CH 2) n N(R 6)(R 7), or CH 2 (CH 2) n N(R 6)(R 7); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2, O, S, SO, or SO 2; n is 0 to 6; * represents a point of attachment to Formula; R 1 is H, C1-C6 alkyl, CH 2 (CH 2) n OH, CH 2 CH CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6, N(R 6)(R 7), CFH 2, CF 2 H, CF 3, F, Cl, Br, I, OCF 3, COR 6, CON(R 6)(R 7), SOR 6, SON(R 6)(R 7), SO 2 R 6, SO 2 N(R 6)(R 7), CN, or NO 2; R 4 is N(R 6)(R 7), OH, OCH 2 (CH 2) n N(R 6)(R 7), or CH 2 (CH 2) n N(R 6)(R 7); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2, O, S, SO, or SO 2; n is 0 to 6; * represents a point of attachment to Formula;