An extracorporeal system for removing carbon dioxide and bicarbonate from a fluid, wherein the extracorporeal system comprises: a cartridge housing having a cavity, a longitudinal axis extending between first and second ends of the body, a fluid inlet adjacent to the first end, and a fluid outlet adjacent to the second end; a first membrane component disposed within the cavity and configured to remove gaseous carbon dioxide from the fluid passing from the fluid inlet in a first direction towards the fluid outlet; a second membrane component disposed within the cavity and configured to remove bicarbonate from the fluid passing between the fluid inlet and the fluid outlet; a first inlet in fluid communication with the first membrane component and configured to deliver a sweep gas to the first membrane component such that the sweep gas is passed through the first membrane component in a second direction; a first outlet in fluid communication with the first membrane component and configured to receive the sweep gas passed through the first membrane component; a second inlet in fluid communication with the second membrane component and configured to deliver a dialysate to the second membrane component such that the dialysate is passed through the second membrane component in a third direction; a second outlet in fluid communication with the second membrane component and configured to receive the dialysate passed through the second membrane component; and characterized by a third membrane component positioned such that the fluid is brought in contact with the third membrane component after passage through the first membrane component and the second membrane component and after the gaseous carbon dioxide and the bicarbonate are removed from the fluid, wherein the third membrane component provides an interface between the fluid and a reconditioning fluid, and is configured to receive the reconditioning fluid, wherein the reconditioning fluid has a composition configured to regulate an ionic composition and acidity of the fluid. a cartridge housing having a cavity, a longitudinal axis extending between first and second ends of the body, a fluid inlet adjacent to the first end, and a fluid outlet adjacent to the second end; a first membrane component disposed within the cavity and configured to remove gaseous carbon dioxide from the fluid passing from the fluid inlet in a first direction towards the fluid outlet; a second membrane component disposed within the cavity and configured to remove bicarbonate from the fluid passing between the fluid inlet and the fluid outlet; a first inlet in fluid communication with the first membrane component and configured to deliver a sweep gas to the first membrane component such that the sweep gas is passed through the first membrane component in a second direction; a first outlet in fluid communication with the first membrane component and configured to receive the sweep gas passed through the first membrane component; a second inlet in fluid communication with the second membrane component and configured to deliver a dialysate to the second membrane component such that the dialysate is passed through the second membrane component in a third direction; a second outlet in fluid communication with the second membrane component and configured to receive the dialysate passed through the second membrane component; and characterized by a third membrane component positioned such that the fluid is brought in contact with the third membrane component after passage through the first membrane component and the second membrane component and after the gaseous carbon dioxide and the bicarbonate are removed from the fluid, wherein the third membrane component provides an interface between the fluid and a reconditioning fluid, and is configured to receive the reconditioning fluid, wherein the reconditioning fluid has a composition configured to regulate an ionic composition and acidity of the fluid.