A method for identifying a plurality of different subjects comprising: (a) hybridizing a plurality of nucleic acids comprising at least one target nucleic acid from a plurality of different subjects to a biochip, wherein said biochip comprises: (i) a first feature comprising a first plurality of identical probes targeting a first subject-specific feature; and (ii) a second feature comprising a second plurality of identical probes targeting a second subject-specific feature; wherein said first plurality of identical probes and said second plurality of identical probes are different from each other; wherein said first feature and said second feature are encompassed in an area less than or equal to an optical resolution of an optical detector; and (b) detecting an integration of a signal from said first feature and a signal from said second feature wherein said signals are integrated into a single resolution element by the optical detector, wherein said signal is generated based on an interaction of said at least one target nucleic acid and said first plurality of identical probes or said second plurality of identical probes; and (c) identifying said plurality of different subjects based on a presence of said at least one target nucleic acid. (a) hybridizing a plurality of nucleic acids comprising at least one target nucleic acid from a plurality of different subjects to a biochip, wherein said biochip comprises: (i) a first feature comprising a first plurality of identical probes targeting a first subject-specific feature; and (ii) a second feature comprising a second plurality of identical probes targeting a second subject-specific feature; wherein said first plurality of identical probes and said second plurality of identical probes are different from each other; wherein said first feature and said second feature are encompassed in an area less than or equal to an optical resolution of an optical detector; and (i) a first feature comprising a first plurality of identical probes targeting a first subject-specific feature; and (ii) a second feature comprising a second plurality of identical probes targeting a second subject-specific feature; wherein said first plurality of identical probes and said second plurality of identical probes are different from each other; wherein said first feature and said second feature are encompassed in an area less than or equal to an optical resolution of an optical detector; and wherein said first plurality of identical probes and said second plurality of identical probes are different from each other; wherein said first feature and said second feature are encompassed in an area less than or equal to an optical resolution of an optical detector; and (b) detecting an integration of a signal from said first feature and a signal from said second feature wherein said signals are integrated into a single resolution element by the optical detector, wherein said signal is generated based on an interaction of said at least one target nucleic acid and said first plurality of identical probes or said second plurality of identical probes; and (c) identifying said plurality of different subjects based on a presence of said at least one target nucleic acid.