A method for manufacture of a removable dental partial prosthesis by moulding, said method comprising the following successive steps: - a step of digital modeling of a partial prosthesis model (10'; 43, 48, 38), the partial prosthesis model representing the partial prosthesis to produce and comprising a gum part (12'; 48) and a tooth part (13'; 38); - a step of producing a partial prosthesis mould (5; 20; 41; 42) from the partial prosthesis model, said mould comprising two half-shells, a lower half-shell (3; 23; 42) comprising an imprint of the tooth part of the prosthesis to produce, and an upper half-shell (4; 21; 41) comprising an imprint of the gum part of the prosthesis to produce and an imprint of existing teeth, the gum part and the teeth part of the prosthesis to produce being partial, the two half-shells (21, 23) being configured to be assembled by juxtaposition against each other, the imprints of each half-shell forming by assembly an imprint of the prosthesis to produce, the mould comprising at least one positioning member of one half-shell relative to the other half-shell, the positioning member comprising at least one support member, formed in the lower half-shell, for supporting the imprint of the existing teeth of the upper half-shell, the positioning member consisting in a complementarity of the imprint of the gum part (21a, 21c) and the existing teeth of the upper half-shell and the imprint of the teeth part (23a, 23c) and of the support member of the lower half-shell; the step of producing a mould comprising: - a sub-step of digital modeling at least partial of a mould model according to the partial prosthesis model, - followed by a sub-step of additive manufacture of at least the lower half-shell according to the mould model, and - a step of producing the partial prosthesis successively comprising at least: a sub-step of providing at least one artificial tooth (44; 45), a sub-step of positioning the artificial tooth in an accommodation of the lower half-shell (3; 23; 42), a sub-step of assembling the mould and a sub-step of casting a filling material in the mould. - a step of digital modeling of a partial prosthesis model (10'; 43, 48, 38), the partial prosthesis model representing the partial prosthesis to produce and comprising a gum part (12'; 48) and a tooth part (13'; 38); - a step of producing a partial prosthesis mould (5; 20; 41; 42) from the partial prosthesis model, said mould comprising two half-shells, a lower half-shell (3; 23; 42) comprising an imprint of the tooth part of the prosthesis to produce, and an upper half-shell (4; 21; 41) comprising an imprint of the gum part of the prosthesis to produce and an imprint of existing teeth, the gum part and the teeth part of the prosthesis to produce being partial, the two half-shells (21, 23) being configured to be assembled by juxtaposition against each other, the imprints of each half-shell forming by assembly an imprint of the prosthesis to produce, the mould comprising at least one positioning member of one half-shell relative to the other half-shell, the positioning member comprising at least one support member, formed in the lower half-shell, for supporting the imprint of the existing teeth of the upper half-shell, the positioning member consisting in a complementarity of the imprint of the gum part (21a, 21c) and the existing teeth of the upper half-shell and the imprint of the teeth part (23a, 23c) and of the support member of the lower half-shell; - a sub-step of digital modeling at least partial of a mould model according to the partial prosthesis model, - followed by a sub-step of additive manufacture of at least the lower half-shell according to the mould model, and - a step of producing the partial prosthesis successively comprising at least: a sub-step of providing at least one artificial tooth (44; 45), a sub-step of positioning the artificial tooth in an accommodation of the lower half-shell (3; 23; 42), a sub-step of assembling the mould and a sub-step of casting a filling material in the mould.