mhurhangee/ep-ind-claims huggingface dataset:
An opioid receptor antagonist represented by one of the following formulae: 1) formula: wherein: R is OH, OCH 3 or OCF 3; Y 3 is hydrogen; R 1, R 2, R 3 and R 4 are each, independently, hydrogen or methyl, wherein at least one of R 1, R 2, R 3 and R 4 is methyl; R 5 is C 1-4 alkyl or -(CH 2) n -phenyl; n is 1, 2 or 3; 2) formula: 3) formula: and 4) formula: or a pharmaceutically acceptable salt thereof. 1) formula: wherein: R is OH, OCH 3 or OCF 3; Y 3 is hydrogen; R 1, R 2, R 3 and R 4 are each, independently, hydrogen or methyl, wherein at least one of R 1, R 2, R 3 and R 4 is methyl; R 5 is C 1-4 alkyl or -(CH 2) n -phenyl; n is 1, 2 or 3; R is OH, OCH 3 or OCF 3; Y 3 is hydrogen; R 1, R 2, R 3 and R 4 are each, independently, hydrogen or methyl, wherein at least one of R 1, R 2, R 3 and R 4 is methyl; R 5 is C 1-4 alkyl or -(CH 2) n -phenyl; n is 1, 2 or 3; 2) formula: 3) formula: and 4) formula:
A method of controlling power provided by a generator (18, 118) to an end system 12 via a frequency converter (14, 114, 614), the method comprising: monitoring the power produced by the generator; diverting, in response to said monitored power exceeding a threshold level, at least some of the power from the output of said generator to an auxiliary system (22, 122, 222, 322, 422, 522, 622); charging at least one energy storage device (24, 324, 424, 524, 624) with said diverted power; delivering, in response to said monitored power being below a threshold level, power to said end system from said auxiliary system by discharging said at least one energy storage device, characterised in that said diverting involves diverting said at least some power away from an input of said frequency converter, and by causing said auxiliary system (22, 122, 222, 322, 422, 522, 622) to absorb reactive power from said generator (18, 118) during said diverting of power from said generator. monitoring the power produced by the generator; diverting, in response to said monitored power exceeding a threshold level, at least some of the power from the output of said generator to an auxiliary system (22, 122, 222, 322, 422, 522, 622); charging at least one energy storage device (24, 324, 424, 524, 624) with said diverted power; delivering, in response to said monitored power being below a threshold level, power to said end system from said auxiliary system by discharging said at least one energy storage device, characterised in that said diverting involves diverting said at least some power away from an input of said frequency converter, and by causing said auxiliary system (22, 122, 222, 322, 422, 522, 622) to absorb reactive power from said generator (18, 118) during said diverting of power from said generator.
A method of operating an energy extraction device to extract energy from a fluctuating energy flow from a renewable energy source, the device comprising: a hydraulic pump driven by a rotating shaft, the rotating shaft driven by a renewable energy source, a hydraulic motor driving a load, at least one low pressure manifold and a high pressure manifold in fluid communication with an outlet of the hydraulic pump, an inlet of the hydraulic motor and an elastically deformable fluid retaining body (147,149), the hydraulic pump and hydraulic motor each comprising a plurality of working chambers (202 A to H) of cyclically varying volume and a plurality of valves for regulating the net displacement of working fluid between each working chamber and each manifold, at least one valve associated with each working chamber being an electronically controlled valve, said electronically controlled valves being operated to select the volume of working fluid displaced by each said working chamber on each cycle of working chamber volume and thereby regulate the net rate of displacement of working fluid by each of the hydraulic pump and the hydraulic motor, the method characterised by measuring the pressure in the high pressure manifold, selecting the net rate of displacement of working fluid by the hydraulic pump responsive to said measured pressure to regulate the torque applied to the said rotating shaft, selecting the net rate of displacement of working fluid by the hydraulic motor to smooth the energy flow to the load, and further selecting the net rate of displacement of working fluid by the hydraulic motor to regulate the pressure in the high pressure manifold to remain within an acceptable pressure range.
A liquid detergent composition comprising: (a) from 2 to 25 wt.% of a C12-C14 alkyl ethoxylated sulfate surfactant; wherein the alkyl ethoxylated sulfate surfactant comprises a C14 alkyl group at a level of at least 50 wt.% of the alkyl ethoxylated sulfate surfactant; wherein the average degree of ethoxylation is from 2.5 to 3.5; wherein with reference to the wt.% of the total ethoxylated portion of said alkyl ethoxylated sulfate surfactant, the level of 1EO is from 10 to 25 wt.%, the level of 2EO is from 15 to 24 wt.%, the level of 3EO is from 20 to 35 wt.%, and the level of 4EO is from 12 to 25 wt.%; and, wherein the C12-C14 alkyl ethoxylated sulfate surfactant includes at most 10 wt.% alkyl chains of C15 and higher; and (b) from 0.5 to 15 wt.%, more preferably from 0.75 to 15 wt.%, even more preferably from 1 to 12 wt.%, most preferably from 1.5 to 10 wt.% of cleaning boosters selected from antiredeposition polymers and soil release polymers, wherein the antiredeposition polymers are alkoxylated polyamines; and/or wherein the soil release polymer is a polyester soil release polymer. (a) from 2 to 25 wt.% of a C12-C14 alkyl ethoxylated sulfate surfactant; wherein the alkyl ethoxylated sulfate surfactant comprises a C14 alkyl group at a level of at least 50 wt.% of the alkyl ethoxylated sulfate surfactant; wherein the average degree of ethoxylation is from 2.5 to 3.5; wherein with reference to the wt.% of the total ethoxylated portion of said alkyl ethoxylated sulfate surfactant, the level of 1EO is from 10 to 25 wt.%, the level of 2EO is from 15 to 24 wt.%, the level of 3EO is from 20 to 35 wt.%, and the level of 4EO is from 12 to 25 wt.%; and, wherein the C12-C14 alkyl ethoxylated sulfate surfactant includes at most 10 wt.% alkyl chains of C15 and higher; and wherein the alkyl ethoxylated sulfate surfactant comprises a C14 alkyl group at a level of at least 50 wt.% of the alkyl ethoxylated sulfate surfactant; wherein the average degree of ethoxylation is from 2.5 to 3.5; wherein with reference to the wt.% of the total ethoxylated portion of said alkyl ethoxylated sulfate surfactant, the level of 1EO is from 10 to 25 wt.%, the level of 2EO is from 15 to 24 wt.%, the level of 3EO is from 20 to 35 wt.%, and the level of 4EO is from 12 to 25 wt.%; and, wherein the C12-C14 alkyl ethoxylated sulfate surfactant includes at most 10 wt.% alkyl chains of C15 and higher; and (b) from 0.5 to 15 wt.%, more preferably from 0.75 to 15 wt.%, even more preferably from 1 to 12 wt.%, most preferably from 1.5 to 10 wt.% of cleaning boosters selected from antiredeposition polymers and soil release polymers, wherein the antiredeposition polymers are alkoxylated polyamines; and/or wherein the soil release polymer is a polyester soil release polymer.
A laminated glass for vehicles comprising at least two glass sheets, and an interlayer and a heat reflecting film having a layer made of silver as a main component, provided between the two glass sheets, which are laminated, wherein the interlayer is provided over the entire surface of the laminated glass, and has a band-shape colored portion along the upper edge portion of the laminated glass, wherein the colored portion is formed by blending a colorant into a thermoplastic resin composition forming the colored portion in the interlayer, and the heat reflecting film is positioned so that an upper end thereof is located above the vicinity of a lower end of the colored portion of the interlayer and at least 50 mm below the upper end of the laminated glass, and said heat reflecting film is provided over substantially the entire surface of the laminated glass except a part or all of the upper edge portion of the laminated glass.
A method for producing γ-Glu-Val and/or a salt thereof, the method comprising the following step: a step of allowing a protein defined in (a), (b), or (c) mentioned below to act on Glu and Val to generate γ-Glu-Val: (a) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22; (b) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22 but including substitution, deletion, insertion, or addition of 1 to 10 amino acid residues, and having γ-glutamylvaline synthetase activity; (c) a protein comprising an amino acid sequence showing an identity of 90% or higher to the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22, and having γ-glutamylvaline synthetase activity. a step of allowing a protein defined in (a), (b), or (c) mentioned below to act on Glu and Val to generate γ-Glu-Val: (a) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22; (b) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22 but including substitution, deletion, insertion, or addition of 1 to 10 amino acid residues, and having γ-glutamylvaline synthetase activity; (c) a protein comprising an amino acid sequence showing an identity of 90% or higher to the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22, and having γ-glutamylvaline synthetase activity. (a) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22; (b) a protein comprising the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22 but including substitution, deletion, insertion, or addition of 1 to 10 amino acid residues, and having γ-glutamylvaline synthetase activity; (c) a protein comprising an amino acid sequence showing an identity of 90% or higher to the amino acid sequence of SEQ ID NO: 6, 10, 16, or 22, and having γ-glutamylvaline synthetase activity.
An exhaust after-treatment composition comprising: a) a compound capable of providing ammonia above about 150 °C; b) an adduct of an α-substituted succinic anhydride with a polyalkylene glycol, a polyalkylene glycol derivative, or a mixture thereof; and c) water; wherein the α-substituted succinic anhydride is a compound of formula wherein R 1 is C 8 -C 22 alkyl, C 8 -C 22 alkenyl, or C 6 -C 10 arylalkyl. a) a compound capable of providing ammonia above about 150 °C; b) an adduct of an α-substituted succinic anhydride with a polyalkylene glycol, a polyalkylene glycol derivative, or a mixture thereof; and c) water;
A method comprising: receiving, by a wireless device, a radio resource control message comprising a configuration parameter for a licensed assisted access, LAA, cell, the configuration parameter comprising an aperiodic sounding reference signal, SRS, subframe parameter; receiving a downlink control information: indicating uplink resources in a plurality of scheduled consecutive subframes of the LAA cell; and triggering an SRS transmission in a subframe of the plurality of scheduled consecutive subframes; and transmitting the SRS in the subframe when the wireless device is allowed to transmit in the subframe according to a listen-before-talk procedure, wherein a position of the subframe for transmitting the SRS in the plurality of scheduled consecutive subframes is determined based on the aperiodic SRS subframe parameter. receiving, by a wireless device, a radio resource control message comprising a configuration parameter for a licensed assisted access, LAA, cell, the configuration parameter comprising an aperiodic sounding reference signal, SRS, subframe parameter; receiving a downlink control information: indicating uplink resources in a plurality of scheduled consecutive subframes of the LAA cell; and triggering an SRS transmission in a subframe of the plurality of scheduled consecutive subframes; and transmitting the SRS in the subframe when the wireless device is allowed to transmit in the subframe according to a listen-before-talk procedure, wherein a position of the subframe for transmitting the SRS in the plurality of scheduled consecutive subframes is determined based on the aperiodic SRS subframe parameter. indicating uplink resources in a plurality of scheduled consecutive subframes of the LAA cell; and triggering an SRS transmission in a subframe of the plurality of scheduled consecutive subframes; and transmitting the SRS in the subframe when the wireless device is allowed to transmit in the subframe according to a listen-before-talk procedure, wherein a position of the subframe for transmitting the SRS in the plurality of scheduled consecutive subframes is determined based on the aperiodic SRS subframe parameter.
A method of identifying a subject having cancer who is likely to benefit from treatment with a second generation MEK1 inhibitor that inhibits the activity of a mutant MEK1 protein having a C121S amino acid substitution, comprising: (a) extracting nucleic acid from cells of the cancer; and (b) sequencing a nucleic acid molecule encoding a MEK1 protein; wherein the presence of nucleotides that produce a C121S amino acid substitution in the MEK1 protein (SEQ ID NO: 4), as compared to wild-type MEK1 protein (SEQ ID NO: 2) identifies the subject as being likely to benefit from treatment with a second generation MEK1 inhibitor that inhibits the activity of a mutant MEK1 protein having a C121S amino acid substitution, the C121S amino acid substitution conferring resistance to RAF and MEK1 inhibitors. (a) extracting nucleic acid from cells of the cancer; and (b) sequencing a nucleic acid molecule encoding a MEK1 protein;
An eye-mountable device (110, 210, 310, 410, 510) comprising: a transparent polymeric material (120, 220) having a concave surface and a convex surface, wherein the concave surface is configured to be removably mounted over a corneal surface of an eye and the convex surface is configured to be compatible with eyelid motion when the concave surface is so mounted; an antenna (170, 270) at least partially embedded in the transparent polymeric (120, 220) material; an expandable member (366, 466, 566) at least partially embedded in the transparent polymeric material (120, 220) and configured to expand by undergoing a change in volume and apply a force to the corneal surface; a sensor (368, 468, 568) at least partially embedded in the transparent polymeric material (120, 220) configured to detect a resistance to deformation of the cornea in response to the force applied by the expandable member (366, 466, 566); and control electronics (150, 250) at least partially embedded in the transparent polymeric material (120, 220), wherein the control electronics (150, 250) are configured to: (i) use the sensor (368, 468, 568) to measure the resistance to deformation of the cornea; and (ii) use the antenna (170, 270) to communicate data indicative of the measured resistance to deformation of the cornea to an external reader, wherein the resistance to deformation of the cornea in response to the force applied by the expandable member (366, 466, 566) is indicative of intraocular pressure of the eye. a transparent polymeric material (120, 220) having a concave surface and a convex surface, wherein the concave surface is configured to be removably mounted over a corneal surface of an eye and the convex surface is configured to be compatible with eyelid motion when the concave surface is so mounted; an antenna (170, 270) at least partially embedded in the transparent polymeric (120, 220) material; an expandable member (366, 466, 566) at least partially embedded in the transparent polymeric material (120, 220) and configured to expand by undergoing a change in volume and apply a force to the corneal surface; a sensor (368, 468, 568) at least partially embedded in the transparent polymeric material (120, 220) configured to detect a resistance to deformation of the cornea in response to the force applied by the expandable member (366, 466, 566); and control electronics (150, 250) at least partially embedded in the transparent polymeric material (120, 220), wherein the control electronics (150, 250) are configured to: (i) use the sensor (368, 468, 568) to measure the resistance to deformation of the cornea; and (ii) use the antenna (170, 270) to communicate data indicative of the measured resistance to deformation of the cornea to an external reader, wherein the resistance to deformation of the cornea in response to the force applied by the expandable member (366, 466, 566) is indicative of intraocular pressure of the eye.
A welding-type system (100, 200, 600), comprising: - a first wire drive to feed an electrode wire through a welding torch; - a tension-compression detector to detect a first tension-compression state of the electrode wire; and characterised by: a bidirectional assisting wire drive to advance the electrode wire from a wire supply to the first drive; and by: - one or more motor controllers (220, 222) to control the first wire drive and the assisting wire drive to put the electrode wire in a predetermined position relative to the welding torch by: - controlling the first wire drive to hold the electrode wire; and - controlling the assisting wire drive to advance or retract the electrode wire based on the first tension-compression state to put the electrode wire in a second tension-compression state. - a first wire drive to feed an electrode wire through a welding torch; - a tension-compression detector to detect a first tension-compression state of the electrode wire; and characterised by: a bidirectional assisting wire drive to advance the electrode wire from a wire supply to the first drive; and by: - one or more motor controllers (220, 222) to control the first wire drive and the assisting wire drive to put the electrode wire in a predetermined position relative to the welding torch by: - controlling the first wire drive to hold the electrode wire; and - controlling the assisting wire drive to advance or retract the electrode wire based on the first tension-compression state to put the electrode wire in a second tension-compression state. a bidirectional assisting wire drive to advance the electrode wire from a wire supply to the first drive; and by: - one or more motor controllers (220, 222) to control the first wire drive and the assisting wire drive to put the electrode wire in a predetermined position relative to the welding torch by: - controlling the first wire drive to hold the electrode wire; and - controlling the assisting wire drive to advance or retract the electrode wire based on the first tension-compression state to put the electrode wire in a second tension-compression state. - one or more motor controllers (220, 222) to control the first wire drive and the assisting wire drive to put the electrode wire in a predetermined position relative to the welding torch by: - controlling the first wire drive to hold the electrode wire; and - controlling the assisting wire drive to advance or retract the electrode wire based on the first tension-compression state to put the electrode wire in a second tension-compression state. - controlling the first wire drive to hold the electrode wire; and - controlling the assisting wire drive to advance or retract the electrode wire based on the first tension-compression state to put the electrode wire in a second tension-compression state.
A toner refill apparatus comprising: a bottle to keep toner; a circuit board that is disposed on the bottle, and to store apparatus information and use history information of the toner refill apparatus; a plurality of terminals to communicate with a communication device of an image forming apparatus; and a circuit member to vary, based on infiltration of toner kept in the bottle being completed, a resistance value between a first terminal and a second terminal among the plurality of terminals, wherein the circuit member comprises: a first resistance that is disposed between a ground terminal and a state terminal; characterised in that the circuit member comprises a second resistance of which one end is commonly connected to one end of the first resistance and the ground terminal; and a fuse of which one end is connected to the other end of the second resistance, and of which another end is connected to the state terminal. a bottle to keep toner; a circuit board that is disposed on the bottle, and to store apparatus information and use history information of the toner refill apparatus; a plurality of terminals to communicate with a communication device of an image forming apparatus; and a circuit member to vary, based on infiltration of toner kept in the bottle being completed, a resistance value between a first terminal and a second terminal among the plurality of terminals, wherein the circuit member comprises: a first resistance that is disposed between a ground terminal and a state terminal; characterised in that the circuit member comprises a second resistance of which one end is commonly connected to one end of the first resistance and the ground terminal; and a fuse of which one end is connected to the other end of the second resistance, and of which another end is connected to the state terminal. a first resistance that is disposed between a ground terminal and a state terminal; characterised in that the circuit member comprises a second resistance of which one end is commonly connected to one end of the first resistance and the ground terminal; and a fuse of which one end is connected to the other end of the second resistance, and of which another end is connected to the state terminal.
Internal inspection device (2, 90) for determining a length of a tubular good, the internal inspection device (2, 90) comprising a first positioning sensor, a second positioning sensor, wherein the internal inspection device (2, 90) is elongated, the first positioning sensor being located on a first end side of the elongated internal inspection device, and the second positioning sensor being located on the other end side of the elongated inspection device, wherein the first positioning sensor is so configured to determine whether the first positioning sensor is located inside the tubular good and the second positioning sensor is so configured to determine whether the second positioning sensor is located inside the tubular good, a displacement sensor for measuring the displacement of the internal inspection device (2, 90) inside the tubular good between a first position and a second position, the internal inspection device (2, 90) further including an electronic computing the length of the tubular good by adding a distance measured by the displacement sensor and a predetermined length, wherein the predetermined length is the distance between the first and second positioning sensors (74, 76).
Hearing device, comprising - an active occlusion reduction unit, characterized by: - at least one first means (R, M, 20, 30) which identifies an impact noise, formed in the auditory canal of the wearer by steps of the wearer of the hearing device, on the basis of the impact noise level and impact noise frequency pattern or on the basis of the impact noise frequency pattern and which reduces an amplification of the occlusion reduction unit when impact noise is present or which switches the occlusion reduction unit off when impact noise is present. - an active occlusion reduction unit, characterized by: - at least one first means (R, M, 20, 30) which identifies an impact noise, formed in the auditory canal of the wearer by steps of the wearer of the hearing device, on the basis of the impact noise level and impact noise frequency pattern or on the basis of the impact noise frequency pattern and which reduces an amplification of the occlusion reduction unit when impact noise is present or which switches the occlusion reduction unit off when impact noise is present.