mhurhangee/ep-ind-claims huggingface dataset:
A method of increasing the sensitivity of cell-based detection of a botulinum neurotoxin, comprising: (i) providing a transfected cell that produces a construct comprising; (a) a first terminus comprising a reporter containing portion, wherein the reporter containing portion exhibits a signal; and, (b) a cleavage site that interacts with the botulinum neurotoxin in a manner that produces a cleavage of the reporter-containing portion from a remainder of the construct; (ii) exposing the transfected cell to the botulinum toxin in a low osmolarity media having an osmolarity of from 220 mOsm to 260 mOsm at an elevated exposure temperature, wherein sensitivity of the transfected cell's response to the botulinum neurotoxin shows a synergistic improvement relative to exposure of the transfected cell to the botulinum neurotoxin in a media having physiological osmolarity and physiological exposure temperature, wherein the physiological exposure temperature is from 35°C to 37°C and the elevated exposure temperature is greater than the physiological exposure temperature and is from 37°C to 39°C. (i) providing a transfected cell that produces a construct comprising; (a) a first terminus comprising a reporter containing portion, wherein the reporter containing portion exhibits a signal; and, (b) a cleavage site that interacts with the botulinum neurotoxin in a manner that produces a cleavage of the reporter-containing portion from a remainder of the construct; (a) a first terminus comprising a reporter containing portion, wherein the reporter containing portion exhibits a signal; and, (b) a cleavage site that interacts with the botulinum neurotoxin in a manner that produces a cleavage of the reporter-containing portion from a remainder of the construct; (ii) exposing the transfected cell to the botulinum toxin in a low osmolarity media having an osmolarity of from 220 mOsm to 260 mOsm at an elevated exposure temperature, wherein sensitivity of the transfected cell's response to the botulinum neurotoxin shows a synergistic improvement relative to exposure of the transfected cell to the botulinum neurotoxin in a media having physiological osmolarity and physiological exposure temperature, wherein the physiological exposure temperature is from 35°C to 37°C and the elevated exposure temperature is greater than the physiological exposure temperature and is from 37°C to 39°C.
A method for producing [bis(2-phosphinoethyl)amine]-carbonylhalohydridoruthenium represented by the following formula (1 A), the method comprising reacting a ruthenium dinuclear complex represented by the following formula (2 A) with a compound represented by the following formula (3 A) in the presence of a primary alcohol and a base: [in the formula (2 A), the solid line represents a single bond and the broken line represents a coordinate bond; and Ru represents a divalent ruthenium ion, X represents a halide ion, and AH represents an aromatic hydrocarbon which may have a substituent], [in the formula (3 A), the solid line represents a single bond; C represents a carbon atom, H represents a hydrogen atom, N represents a nitrogen atom, and P represents a phosphorus atom; each of R 1, R 2, R 3 and R 4 independently represents a group selected from the group consisting of an alkyl group, a cycloalkyl group, an alkenyl group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, and an aralkyl group which may have a substituent; R 1 and R 2 may be bonded to each other to form a ring which may have a substituent; R 3 and R 4 may be bonded to each other to form a ring which may have a substituent; each of R 5, R 6, R 7, R 8, R 9, R 10, R 11 and R 12 independently represents a hydrogen atom or a group selected from the group consisting of an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, and an aralkyl group; and each of R 5 to R 12 may be bonded to each other to form a ring], [in the formula (1 A), the solid line represents a single bond, the triple line represents a triple bond, and the broken line represents a coordinate bond; C represents a carbon atom, H represents a hydrogen atom, N represents a nitrogen atom, O represents an oxygen atom, and P represents a phosphorus atom; Ru represents a divalent ruthenium ion and X represents a halide ion; each of R 1, R 2, R 3 and R 4 independently represents a group selected from the group consisting of an alkyl group, a cycloalkyl group, an alkenyl group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, and an aralkyl group which may have a substituent; R 1 and R 2 may be bonded to each other to form a ring which may have a substituent; R 3 and R 4 may be bonded to each other to form a ring which may have a substituent; each of R 5, R 6, R 7, R 8, R 9, R 10, R 11 and R 12 independently represents a hydrogen atom or a group selected from the group consisting of an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, and an aralkyl group; and each of R 5 to R 12 may be bonded to each other to form a ring].
Control relay, having a housing and functional circuitry covered by the housing to perform the function of the control relay, further having a user interface system, said user interface system comprising a directional input unit having an operating member and operable to receive at a point in time an input specifying one of a selection of functional parameters and to communicate the specified functional parameters to the functional circuitry, characterized in that the said input unit is operable to receive said functional parameter in response to a user operation of rotating and pushing the operating member, wherein the operating member is covered by the housing, wherein the operating member is configured to be operated by the user by means of a tool, wherein the housing has an operational opening giving access for the tool to the operating member.
Rotary gas flow meter comprising a pair of three-toothed rotors (2, 3), each of which has the shape of a double helical gear, wherein the first rotor is a mirror reflection of the second rotor, and the rotors (2, 3) are adapted to rotate in opposite directions; moreover, the flow meter comprises a body sealing the rotors (2, 3) forming measurement chambers (5, 6), formed between the outer surfaces of the rotors and the inner surface of the body. characterised in that the measurement chambers (5, 6) have strictly defined volume, and the rotors (2, 3) are adapted not to contact each other and a geometry of rotors (2, 3) is adapted to provide an internal balance of axial forces, and the rotors (2, 3) are synchronised via an external module synchronising the rotation of the rotors (2, 3). a pair of three-toothed rotors (2, 3), each of which has the shape of a double helical gear, wherein the first rotor is a mirror reflection of the second rotor, and the rotors (2, 3) are adapted to rotate in opposite directions; moreover, the flow meter comprises a body sealing the rotors (2, 3) forming measurement chambers (5, 6), formed between the outer surfaces of the rotors and the inner surface of the body. the measurement chambers (5, 6) have strictly defined volume, and the rotors (2, 3) are adapted not to contact each other and a geometry of rotors (2, 3) is adapted to provide an internal balance of axial forces, and the rotors (2, 3) are synchronised via an external module synchronising the rotation of the rotors (2, 3).
A touch interface having simultaneous sensing and actuation comprising: an insulating substrate; a plurality of electrodes connected to a front surface of the insulating substrate and being arranged in a pattern; an electronic controller configured to connect each electrode to sensing voltage pulses and actuating voltage pulses; said electronic controller configured to produce a haptic effect by applying the actuating voltage pulses to said electrodes, wherein the electronic controller is configured to control the haptic effect by modulating one or more of a duration of the actuating voltage pulses, frequency of the actuating voltage pulses, and number of actuating voltage pulses; and said electronic controller configured to measure the locations of touch points by applying the sensing voltage pulses to said electrodes, characterised in that the electronic controller is configured to reduce or eliminate a user's perception of the sensing voltage pulses by modulating one or more of a duration of the sensing voltage pulses and frequency of the sensing voltage pulses, such that the haptic effect is more perceptible to the user than the sensing voltage pulses. an insulating substrate; a plurality of electrodes connected to a front surface of the insulating substrate and being arranged in a pattern; an electronic controller configured to connect each electrode to sensing voltage pulses and actuating voltage pulses; said electronic controller configured to produce a haptic effect by applying the actuating voltage pulses to said electrodes, wherein the electronic controller is configured to control the haptic effect by modulating one or more of a duration of the actuating voltage pulses, frequency of the actuating voltage pulses, and number of actuating voltage pulses; and said electronic controller configured to measure the locations of touch points by applying the sensing voltage pulses to said electrodes, characterised in that the electronic controller is configured to reduce or eliminate a user's perception of the sensing voltage pulses by modulating one or more of a duration of the sensing voltage pulses and frequency of the sensing voltage pulses, such that the haptic effect is more perceptible to the user than the sensing voltage pulses.
Lighting system comprising at least one connection element, in particular plug and/or clamping connection element, and also at least one luminous strip having at least one strip-shaped standard printed circuit board, wherein the standard printed circuit board is equipped with at least two semiconductor light sources, in particular light-emitting diodes, and has at least one contact region arranged between at least two semiconductor light sources, wherein the contact region is embodied such that it can be severed, and the contact region and the connection element are configured in such a way that, after severing of the contact region, the connection element can be applied to the contact region and at least one electric circuit on the standard printed circuit board can be closed by means of the connection element being applied to the contact region, characterized in that the arrangement of contacts (14a, 14b) in the contact region is embodied in a manner dependent on the number of semiconductor light sources between a current feed-in location and/or an end location of the luminous strip and the contact region and the position of the contacts (14a, 14b) is correlated with the number of semiconductor light sources that have been separated or have remained.
A method of forming a ceramic matrix composite, the method comprising: applying a boron nitride aerogel to a fibrous material to form a pretreated fibrous material; depositing, using chemical vapor infiltration, a BN interface coating on the pretreated fibrous material; and depositing a matrix on the BN IFC and the pretreated fibrous material. applying a boron nitride aerogel to a fibrous material to form a pretreated fibrous material; depositing, using chemical vapor infiltration, a BN interface coating on the pretreated fibrous material; and depositing a matrix on the BN IFC and the pretreated fibrous material.
Elongated smoking article extending in a longitudinal direction, comprising: a cylindrical smoking body with a combustible material surrounded by a wrapping paper; a filter element configured to reduce substances from combustion gases drawn through the filter element from the burning smoking body, wherein a first base area of the filter element faces a base area of the smoking body and a second base area is an open base area; and a tipping paper enclosing the smoking body and the filter element and being attached to external surfaces (13, 21) of the smoking body and the filter element, wherein a flavoring is disposed in or on the tipping paper such that the flavoring is spaced apart from the second base area in the longitudinal direction, wherein a distribution of the flavoring disposed in or on the tipping paper spaced apart from the second base area varies in the longitudinal direction, wherein the amount and/or type of flavoring contacting a smoker's lips depends on a translational state of the elongated smoking article with respect to the longitudinal direction. a cylindrical smoking body with a combustible material surrounded by a wrapping paper; a filter element configured to reduce substances from combustion gases drawn through the filter element from the burning smoking body, wherein a first base area of the filter element faces a base area of the smoking body and a second base area is an open base area; and a tipping paper enclosing the smoking body and the filter element and being attached to external surfaces (13, 21) of the smoking body and the filter element, wherein a flavoring is disposed in or on the tipping paper such that the flavoring is spaced apart from the second base area in the longitudinal direction, wherein a distribution of the flavoring disposed in or on the tipping paper spaced apart from the second base area varies in the longitudinal direction, wherein the amount and/or type of flavoring contacting a smoker's lips depends on a translational state of the elongated smoking article with respect to the longitudinal direction.
A stop flange, comprising: a flange body having a first longitudinal bore and a radial bore; a securing segment disposed in the said radial bore; a locking mechanism disposed in the said radial bore, the locking mechanism comprising: a bushing having a proximate end with a cavity and a lip; a fastener having a head disposed in the said cavity; and a cylinder coupled with the said fastener and the said securing segment; wherein the fastener further comprises a circumferential channel formed on the said head for receiving suitable screw gaskets for maintaining contact with the said head and said bushing cavity. a flange body having a first longitudinal bore and a radial bore; a securing segment disposed in the said radial bore; a locking mechanism disposed in the said radial bore, the locking mechanism comprising: a bushing having a proximate end with a cavity and a lip; a fastener having a head disposed in the said cavity; and a cylinder coupled with the said fastener and the said securing segment; a bushing having a proximate end with a cavity and a lip; a fastener having a head disposed in the said cavity; and a cylinder coupled with the said fastener and the said securing segment; wherein the fastener further comprises a circumferential channel formed on the said head for receiving suitable screw gaskets for maintaining contact with the said head and said bushing cavity.
A wafer supporting mechanism (10, 110) comprising: a wafer supporting table; and a movable part (15,115) supported by the wafer supporting table, wherein the wafer supporting table comprises a first surface opposing a back surface (Wb) of a wafer to be placed, and a wafer supporting portion for transfer configured for supporting the wafer during transfer, which stands up from said first surface and is provided further toward an inner side than an outer peripheral edge of the wafer to be placed; wherein the movable part (15, 115) comprises a wafer supporting portion for film formation (16,116) configured to support the wafer during film formation, which is positioned further toward an outer peripheral side of the wafer to be placed than the wafer supporting portion for transfer and is relatively movable with respect to the wafer supporting table in a standing direction of the wafer supporting portion for transfer. a wafer supporting table; and a movable part (15,115) supported by the wafer supporting table, wherein the wafer supporting table comprises a first surface opposing a back surface (Wb) of a wafer to be placed, and a wafer supporting portion for transfer configured for supporting the wafer during transfer, which stands up from said first surface and is provided further toward an inner side than an outer peripheral edge of the wafer to be placed; wherein the movable part (15, 115) comprises a wafer supporting portion for film formation (16,116) configured to support the wafer during film formation, which is positioned further toward an outer peripheral side of the wafer to be placed than the wafer supporting portion for transfer and is relatively movable with respect to the wafer supporting table in a standing direction of the wafer supporting portion for transfer. a first surface opposing a back surface (Wb) of a wafer to be placed, and a wafer supporting portion for transfer configured for supporting the wafer during transfer, which stands up from said first surface and is provided further toward an inner side than an outer peripheral edge of the wafer to be placed; wherein the movable part (15, 115) comprises a wafer supporting portion for film formation (16,116) configured to support the wafer during film formation, which is positioned further toward an outer peripheral side of the wafer to be placed than the wafer supporting portion for transfer and is relatively movable with respect to the wafer supporting table in a standing direction of the wafer supporting portion for transfer.
Device for degassing hydraulic oil and for arrangement on or at a tank of hydraulic oil, having a drive unit which comprises a motor and comprises a pump which is able to be driven by the motor, from which pump hydraulic oil to be degassed flows via a nozzle which is adjoined by a flow channel with a cross section that is significantly larger in comparison with the throughflow cross section of the nozzle, wherein the drive unit, the nozzle and the flow channel are combined to form a degassing module which is able to be handled as a whole, wherein, for the component forming the flow channel, there is provided an enclosure which is filled with the hydraulic oil and which has an opening to the surroundings, via which opening gas bubbles which have formed pass into the surroundings, wherein one end of the flow channel is immersed into the hydraulic oil situated in the enclosure, whose level in the enclosure is kept constant by means of an overflow line (56; 65), wherein a degassing unit, comprising the nozzle and the flow channel, is immersed into the hydraulic oil to a great extent, wherein the overflow line (56; 65) is guided from within the enclosure to the outside through a passage.
Securing system which secures the storage of at least one filled large-capacity container on a storage surface, comprising the large-capacity container, a securing element which is arranged on a container upper side opposite a container base, the storage surface and a restraint by means of a tension strap, characterised in that the securing element is formed by a cover part in the form of a closure lid having a rim, wherein the restraint, for the tensioned fastening of the large-capacity container, is connected to the rim and to fixing points of the storage surface or fixing points associated therewith, and wherein the closure lid, for closing a filling opening on the container upper side, is a necessary part of the large-capacity container which is erected from at least one blank of material that is foldable against restoring force, wherein the closure lid has a closure lid rim which engages positively over an opening rim of the filling opening, in that the closure lid is formed by a lid blank of material that is foldable against restoring force, which lid blank can be erected with rim zones which are foldable about preformed base fold lines and form the closure lid rim, and in that there is formed at least one double flap which projects from the closure lid rim and forms part of the lid blank and which has a base flap protruding from the closure lid rim and a fold-over flap which is hinged to and folded against the base flap, which flaps are releasably fixed to one another in a retaining connection and thereby form a shallow space with a passage through which at least one tight tension strap of the restraint is captively guided, wherein the at least one tension strap is so guided that the double flap is urged in the direction towards the container base and against a container wall of the large-capacity container beneath the closure lid rim.
A fragrance formulation comprising ethyl 4-methyl-2-oxocyclohexane-1-carboxylate, a tautomer thereof, or a mixture thereof and a complementary fragrance compound.
An online colorimetric analyzer for providing an indication of a material in a sample, the analyzer comprising: a peristaltic pump configured to convey the sample; a photometric cell operably coupled to the peristaltic pump to receive the sample; an illumination source disposed to direct illumination through the sample in the photometric cell along an optical axis; a photodetector disposed to receive illumination passing through the photometric cell along the optical axis and provide a signal indicative of a color of the sample; a controller coupled to the illumination source, the photodetector and the peristaltic pump; and wherein the optical axis is defined by a straight line connecting the illumination source and the photodetector; wherein the optical axis is tilted relative to vertical such that illumination from the illumination source intersect a surface of liquid present when the photometric cell is partially filled at an angle of incidence different from 0° on the surface of said liquid and is reflected away from the optical axis; and wherein the optical axis does not intersect said surface of liquid when the photometric cell is empty or full. a peristaltic pump configured to convey the sample; a photometric cell operably coupled to the peristaltic pump to receive the sample; an illumination source disposed to direct illumination through the sample in the photometric cell along an optical axis; a photodetector disposed to receive illumination passing through the photometric cell along the optical axis and provide a signal indicative of a color of the sample; a controller coupled to the illumination source, the photodetector and the peristaltic pump; and wherein the optical axis is defined by a straight line connecting the illumination source and the photodetector; wherein the optical axis is tilted relative to vertical such that illumination from the illumination source intersect a surface of liquid present when the photometric cell is partially filled at an angle of incidence different from 0° on the surface of said liquid and is reflected away from the optical axis; and wherein the optical axis does not intersect said surface of liquid when the photometric cell is empty or full.