An ophthalmic surgical system comprising: a handheld probe comprising a housing sized and shaped for grasping by a user; and a tip extending from the housing and being sized to penetrate and treat an eye of a patient, the tip including an aspiration lumen arranged to carry material away from the eye; and a peristaltic pump (200, 500, 600, 700, 750, 800, 900) disposed within the housing, the peristaltic pump comprising a deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) comprising a conduit lumen extending therethrough, the conduit lumen in fluid communication with the aspiration lumen; a plurality of rollers (502, 602, 702, 704, 802, 902), each roller of the plurality of rollers being in contact with the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) and comprising an outer peripheral surface (503, 703, 715, 803), each roller being engaged with the deformable conduit to cause the deformable conduit to deform; and a roller driver (510, 650, 710, 810, 910) in contact with the outer peripheral surface (503, 703, 715, 803) of each roller of the plurality of rollers (502, 602, 702, 704, 802, 902), the rollers being movable along the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) in response to movement of the roller driver to cause movement of material within the conduit lumen therealong; characterized in that the rollers are spherical and in that the roller driver (510, 650, 710, 810, 910) comprises a rotating plate or a rotating cylinder having a surface that frictionally engages the outer peripheral surfaces of the rollers to move the rollers along the deformable conduit to urge the material in the deformable conduit to flow. a handheld probe comprising a housing sized and shaped for grasping by a user; and a tip extending from the housing and being sized to penetrate and treat an eye of a patient, the tip including an aspiration lumen arranged to carry material away from the eye; and a peristaltic pump (200, 500, 600, 700, 750, 800, 900) disposed within the housing, the peristaltic pump comprising a deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) comprising a conduit lumen extending therethrough, the conduit lumen in fluid communication with the aspiration lumen; a plurality of rollers (502, 602, 702, 704, 802, 902), each roller of the plurality of rollers being in contact with the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) and comprising an outer peripheral surface (503, 703, 715, 803), each roller being engaged with the deformable conduit to cause the deformable conduit to deform; and a roller driver (510, 650, 710, 810, 910) in contact with the outer peripheral surface (503, 703, 715, 803) of each roller of the plurality of rollers (502, 602, 702, 704, 802, 902), the rollers being movable along the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) in response to movement of the roller driver to cause movement of material within the conduit lumen therealong; a housing sized and shaped for grasping by a user; and a tip extending from the housing and being sized to penetrate and treat an eye of a patient, the tip including an aspiration lumen arranged to carry material away from the eye; and a peristaltic pump (200, 500, 600, 700, 750, 800, 900) disposed within the housing, the peristaltic pump comprising a deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) comprising a conduit lumen extending therethrough, the conduit lumen in fluid communication with the aspiration lumen; a plurality of rollers (502, 602, 702, 704, 802, 902), each roller of the plurality of rollers being in contact with the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) and comprising an outer peripheral surface (503, 703, 715, 803), each roller being engaged with the deformable conduit to cause the deformable conduit to deform; and a roller driver (510, 650, 710, 810, 910) in contact with the outer peripheral surface (503, 703, 715, 803) of each roller of the plurality of rollers (502, 602, 702, 704, 802, 902), the rollers being movable along the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) in response to movement of the roller driver to cause movement of material within the conduit lumen therealong; a deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) comprising a conduit lumen extending therethrough, the conduit lumen in fluid communication with the aspiration lumen; a plurality of rollers (502, 602, 702, 704, 802, 902), each roller of the plurality of rollers being in contact with the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) and comprising an outer peripheral surface (503, 703, 715, 803), each roller being engaged with the deformable conduit to cause the deformable conduit to deform; and a roller driver (510, 650, 710, 810, 910) in contact with the outer peripheral surface (503, 703, 715, 803) of each roller of the plurality of rollers (502, 602, 702, 704, 802, 902), the rollers being movable along the deformable conduit (114, 132, 142, 540, 640, 740, 760, 840, 860, 940, 960) in response to movement of the roller driver to cause movement of material within the conduit lumen therealong; characterized in that the rollers are spherical and in that the roller driver (510, 650, 710, 810, 910) comprises a rotating plate or a rotating cylinder having a surface that frictionally engages the outer peripheral surfaces of the rollers to move the rollers along the deformable conduit to urge the material in the deformable conduit to flow.