A robotic catheter procedure system for performing a procedure to treat a vascular lesion, comprising: a bedside system, the bedside system comprising: a first percutaneous device including an end section, the end section structured to allow the first percutaneous device to create a bore through the vascular lesion; a second percutaneous device; a first actuating mechanism configured to engage and to impart movement to the first percutaneous device; and a second actuating mechanism configured to engage and to impart movement to the second percutaneous device; and a remote workstation, the remote workstation comprising: a user interface comprising controls; and a control system operatively coupled to the user interface and to the bedside system, the control system controlling: the first actuating mechanism to cause movement of the first percutaneous device; and the second actuating mechanism to cause movement of the second percutaneous device; and characterized in that the control system is configured to provide movement of the first percutaneous device and the second percutaneous device by user operation of a single input of the controls; wherein operation of the single input control during advancement of the first percutaneous device controls movement of both the first percutaneous device and the second percutaneous device such that the relative motion between the first percutaneous device and the second percutaneous device is substantially zero. a bedside system, the bedside system comprising: a first percutaneous device including an end section, the end section structured to allow the first percutaneous device to create a bore through the vascular lesion; a second percutaneous device; a first actuating mechanism configured to engage and to impart movement to the first percutaneous device; and a second actuating mechanism configured to engage and to impart movement to the second percutaneous device; and a first percutaneous device including an end section, the end section structured to allow the first percutaneous device to create a bore through the vascular lesion; a second percutaneous device; a first actuating mechanism configured to engage and to impart movement to the first percutaneous device; and a second actuating mechanism configured to engage and to impart movement to the second percutaneous device; and a remote workstation, the remote workstation comprising: a user interface comprising controls; and a control system operatively coupled to the user interface and to the bedside system, the control system controlling: the first actuating mechanism to cause movement of the first percutaneous device; and the second actuating mechanism to cause movement of the second percutaneous device; and characterized in that the control system is configured to provide movement of the first percutaneous device and the second percutaneous device by user operation of a single input of the controls; wherein operation of the single input control during advancement of the first percutaneous device controls movement of both the first percutaneous device and the second percutaneous device such that the relative motion between the first percutaneous device and the second percutaneous device is substantially zero. a user interface comprising controls; and a control system operatively coupled to the user interface and to the bedside system, the control system controlling: the first actuating mechanism to cause movement of the first percutaneous device; and the second actuating mechanism to cause movement of the second percutaneous device; and characterized in that the control system is configured to provide movement of the first percutaneous device and the second percutaneous device by user operation of a single input of the controls; wherein operation of the single input control during advancement of the first percutaneous device controls movement of both the first percutaneous device and the second percutaneous device such that the relative motion between the first percutaneous device and the second percutaneous device is substantially zero. the first actuating mechanism to cause movement of the first percutaneous device; and the second actuating mechanism to cause movement of the second percutaneous device; and characterized in that the control system is configured to provide movement of the first percutaneous device and the second percutaneous device by user operation of a single input of the controls; wherein operation of the single input control during advancement of the first percutaneous device controls movement of both the first percutaneous device and the second percutaneous device such that the relative motion between the first percutaneous device and the second percutaneous device is substantially zero.