Cleaning and disinfection system for handrails of escalators and moving walkways wherein the system comprising a cleaning module, a module for subjecting the surface of a handrail to ultraviolet light, and a drying module, wherein: a. the cleaning module comprises two blocks: i. a first block, comprising a pair of shafts of the first block, which comprise an upper shaft of the first block (5.1) and a lower shaft of the first block (5.2), a second block comprising a pair of shafts of the second block, which comprise an upper shaft of the second block (9.1) and a lower shaft of the second block (9.2), which promote the rotation of two fabric reels, one each block, by means of drive belts that connect the shafts of the first block and the shafts of the second block and that are driven by at least one electric motor synchronized with the rotation of the escalator or moving walkway, providing the winding/unwinding of the fabrics; ii. tanks connected to hoses that have coupled injectors that spray the fabrics; iii. the shafts of the first block and the shafts of the second block are positioned vertically in such a way that the fabrics, when moving, contact the surface of a handrail, removing larger debris from the surface of the handrail and then disinfecting the surface of the handrail respectively; b. module for subjecting the handrail surface to ultraviolet light, which comprises at least one ultraviolet light source and located such that its action occurs after the disinfection step performed by the cleaning module and before the action of the drying module, said drying module comprising at least one dryer or at least one heat source. a. the cleaning module comprises two blocks: i. a first block, comprising a pair of shafts of the first block, which comprise an upper shaft of the first block (5.1) and a lower shaft of the first block (5.2), a second block comprising a pair of shafts of the second block, which comprise an upper shaft of the second block (9.1) and a lower shaft of the second block (9.2), which promote the rotation of two fabric reels, one each block, by means of drive belts that connect the shafts of the first block and the shafts of the second block and that are driven by at least one electric motor synchronized with the rotation of the escalator or moving walkway, providing the winding/unwinding of the fabrics; ii. tanks connected to hoses that have coupled injectors that spray the fabrics; iii. the shafts of the first block and the shafts of the second block are positioned vertically in such a way that the fabrics, when moving, contact the surface of a handrail, removing larger debris from the surface of the handrail and then disinfecting the surface of the handrail respectively; i. a first block, comprising a pair of shafts of the first block, which comprise an upper shaft of the first block (5.1) and a lower shaft of the first block (5.2), a second block comprising a pair of shafts of the second block, which comprise an upper shaft of the second block (9.1) and a lower shaft of the second block (9.2), which promote the rotation of two fabric reels, one each block, by means of drive belts that connect the shafts of the first block and the shafts of the second block and that are driven by at least one electric motor synchronized with the rotation of the escalator or moving walkway, providing the winding/unwinding of the fabrics; ii. tanks connected to hoses that have coupled injectors that spray the fabrics; iii. the shafts of the first block and the shafts of the second block are positioned vertically in such a way that the fabrics, when moving, contact the surface of a handrail, removing larger debris from the surface of the handrail and then disinfecting the surface of the handrail respectively; b. module for subjecting the handrail surface to ultraviolet light, which comprises at least one ultraviolet light source and located such that its action occurs after the disinfection step performed by the cleaning module and before the action of the drying module, said drying module comprising at least one dryer or at least one heat source.