A medical device for detecting anodal cardiac capture, comprising: a plurality of electrodes (20, 22, 24, 26, 30, 32, 34, 36) for sensing cardiac signals and delivering cardiac pacing pulses; a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the plurality of electrodes; cardiac signal sensing circuitry (70, 62) for receiving signals from the plurality of electrodes; and a controller (52, 54) configured to: control the therapy delivery module to deliver a first pacing pulse using a first bipole comprising a first cathode and a first anode and deliver a second pacing pulse using the first cathode and a second anode; measure a first response of a received cardiac signal to the first pacing pulse; measure a second response of the received cardiac signal to the second pacing pulse; detect anodal capture of the first pacing pulse at the first anode in response to a first difference between the first response and the second response; and characterized in that the controller is configured to measure the responses to the first and second pacing pulses respectively by measuring a first conduction time between the first pacing pulse and a subsequent depolarization sensed at a sensing electrode configured to be positioned a distance from the first bipole and a second conduction time between the second pacing pulse and a subsequent depolarization sensed at the sensing electrode. a plurality of electrodes (20, 22, 24, 26, 30, 32, 34, 36) for sensing cardiac signals and delivering cardiac pacing pulses; a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the plurality of electrodes; cardiac signal sensing circuitry (70, 62) for receiving signals from the plurality of electrodes; and a controller (52, 54) configured to: control the therapy delivery module to deliver a first pacing pulse using a first bipole comprising a first cathode and a first anode and deliver a second pacing pulse using the first cathode and a second anode; measure a first response of a received cardiac signal to the first pacing pulse; measure a second response of the received cardiac signal to the second pacing pulse; detect anodal capture of the first pacing pulse at the first anode in response to a first difference between the first response and the second response; and characterized in that the controller is configured to measure the responses to the first and second pacing pulses respectively by measuring a first conduction time between the first pacing pulse and a subsequent depolarization sensed at a sensing electrode configured to be positioned a distance from the first bipole and a second conduction time between the second pacing pulse and a subsequent depolarization sensed at the sensing electrode. control the therapy delivery module to deliver a first pacing pulse using a first bipole comprising a first cathode and a first anode and deliver a second pacing pulse using the first cathode and a second anode; measure a first response of a received cardiac signal to the first pacing pulse; measure a second response of the received cardiac signal to the second pacing pulse; detect anodal capture of the first pacing pulse at the first anode in response to a first difference between the first response and the second response; and characterized in that the controller is configured to measure the responses to the first and second pacing pulses respectively by measuring a first conduction time between the first pacing pulse and a subsequent depolarization sensed at a sensing electrode configured to be positioned a distance from the first bipole and a second conduction time between the second pacing pulse and a subsequent depolarization sensed at the sensing electrode.