A compound of the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein: W is -C(=O)NR 4 -, -NR 4 C(=O)- or -NR 4 -NR 4 -C(=O)-; V is C 1 -C 6 alkylene that is substituted with from 0 to 4 substituents independently chosen from: (i) C 1 -C 4 alkyl, (C 3 -C 8 cycloalkyl)C 0 -C 2 alkyl and phenylC 0 -C 2 alkyl; (ii) substituents that are taken together, with any intervening carbon atoms, to form a 3- to 7-membered cycloalkyl or a 4- to 7-membered heterocycloalkyl ring; and (iii) substituents that are taken together with R 4 and any intervening atoms to form a 4- to 7-membered heterocycloalkyl; Y is phenyl or 5- to 6-membered heteroaryl, each of which is substituted with from 0 to 3 substituents independently chosen from hydroxy, halogen, cyano, amino, nitro, oxo, aminocarbonyl, aminosulfonyl, -COOH, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 2 -C 6 alkyl ether, C 1 -C 6 alkanoyl, C 1 -C 6 alkylsulfonyl, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl and mono- or di-(C 1 -C 6 alkyl)amino; R 2 represents from 0 to 2 substituents independently chosen from halogen, cyano, amino, nitro, aminocarbonyl, aminosulfonyl, -COOH, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkanoyl, C 2 -C 6 alkyl ether, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, mono- or di-(C 1 -C 6 alkyl)amino, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkanoylamino, mono- or di-(C 1 -C 6 alkyl)aminocarbonyl, mono- or di-(C 1 -C 6 alkyl)aminosulfonyl and (C 1 -C 6 alkyl)sulfonylamino; Each R 4 hydrogen or C 1 -C 4 alkyl,; Either: (i) each R 5 is independently hydrogen, -COOH, C 1 -C 6 alkyl or (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, such that at least one R 5 is not hydrogen; or (ii) both R 5 moieties are taken together, with the carbon atom to which they are bound, to form a C 3 -C 7 cycloalkyl; and R A is phenyl or 5-6 membered heteroaryl that is substituted with from 0 to 4 substituents independently chosen from oxo, amino, halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 2 -C 6 alkyl ether, mono- or di-(C 1 -C 6 alkyl)amino. W is -C(=O)NR 4 -, -NR 4 C(=O)- or -NR 4 -NR 4 -C(=O)-; V is C 1 -C 6 alkylene that is substituted with from 0 to 4 substituents independently chosen from: (i) C 1 -C 4 alkyl, (C 3 -C 8 cycloalkyl)C 0 -C 2 alkyl and phenylC 0 -C 2 alkyl; (ii) substituents that are taken together, with any intervening carbon atoms, to form a 3- to 7-membered cycloalkyl or a 4- to 7-membered heterocycloalkyl ring; and (iii) substituents that are taken together with R 4 and any intervening atoms to form a 4- to 7-membered heterocycloalkyl; Y is phenyl or 5- to 6-membered heteroaryl, each of which is substituted with from 0 to 3 substituents independently chosen from hydroxy, halogen, cyano, amino, nitro, oxo, aminocarbonyl, aminosulfonyl, -COOH, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 2 -C 6 alkyl ether, C 1 -C 6 alkanoyl, C 1 -C 6 alkylsulfonyl, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl and mono- or di-(C 1 -C 6 alkyl)amino; R 2 represents from 0 to 2 substituents independently chosen from halogen, cyano, amino, nitro, aminocarbonyl, aminosulfonyl, -COOH, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 aminoalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkanoyl, C 2 -C 6 alkyl ether, (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, mono- or di-(C 1 -C 6 alkyl)amino, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkanoylamino, mono- or di-(C 1 -C 6 alkyl)aminocarbonyl, mono- or di-(C 1 -C 6 alkyl)aminosulfonyl and (C 1 -C 6 alkyl)sulfonylamino; (i) each R 5 is independently hydrogen, -COOH, C 1 -C 6 alkyl or (C 3 -C 7 cycloalkyl)C 0 -C 4 alkyl, such that at least one R 5 is not hydrogen; or (ii) both R 5 moieties are taken together, with the carbon atom to which they are bound, to form a C 3 -C 7 cycloalkyl; and R A is phenyl or 5-6 membered heteroaryl that is substituted with from 0 to 4 substituents independently chosen from oxo, amino, halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 2 -C 6 alkyl ether, mono- or di-(C 1 -C 6 alkyl)amino.