A compound of formula, a N- oxide form, an addition salt or a stereo-chemically isomeric form thereof, wherein n is 0 or 1; s is 0 or 1; X is -N= or -CR 4 =, wherein R 4 is hydrogen or taken together with R 1 may form a bivalent radical of formula -CH=CH-CH=CH-; Y is -N< or -CH<; Q is -NH-, -O-, -C -, -CH 2 -CH 2 - or -CHR 5 -, wherein R 5 is hydrogen, hydroxy, C 1-6 alkyl, arylC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxyC 1-6 alkylamino or haloindazolyl; R 1 is C 1-6 alkyl or thienyl; R 2 is hydrogen; R 3 is hydrogen, C 1-6 alkyl or a radical selected from -NR 6 R 7 (a-1), -O-H (a-2), -O-R 8 (a-3), -S- R 9 (a-4), or -C≡N (a-5), wherein R 6 is -CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, thienylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindazolylpiperidinylC 1-6 alkyl, or arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl; and R 7 is hydrogen or C 1-6 alkyl; R 8 is C 1-6 alkyl, C 1-6 alkylcarbonyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; and R 9 is di(C 1-6 alkyl)aminoC 1-6 alkyl; or R 3 is a group of formula -(CH 2) t -Z- (b-1), wherein t is 0, 1 or 2; Z is a heterocyclic ring system selected from wherein each R 10 independently is hydrogen, C 1-6 alkyl, aminocarbonyl, hydroxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, di(phenylC 2-6 alkenyl), piperidinylC 1-6 alkyl, C 1-10 cycloalkyl, C 1-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, morpholino, C 1-6 alkylimidazolyl, or pyridinylC 1-6 alkylamino; each R 11 independently is hydrogen, hydroxy, piperidinyl or aryl; aryl is phenyl or phenyl substituted with halo, C 1-6 alkyl or C 1-6 alkyloxy. n is 0 or 1; s is 0 or 1; X is -N= or -CR 4 =, wherein R 4 is hydrogen or taken together with R 1 may form a bivalent radical of formula -CH=CH-CH=CH-; Y is -N< or -CH<; Q is -NH-, -O-, -C -, -CH 2 -CH 2 - or -CHR 5 -, wherein R 5 is hydrogen, hydroxy, C 1-6 alkyl, arylC 1-6 alkyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxyC 1-6 alkylamino or haloindazolyl; R 1 is C 1-6 alkyl or thienyl; R 2 is hydrogen; R 3 is hydrogen, C 1-6 alkyl or a radical selected from -NR 6 R 7 (a-1), -O-H (a-2), -O-R 8 (a-3), -S- R 9 (a-4), or -C≡N (a-5), wherein R 6 is -CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, thienylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindazolylpiperidinylC 1-6 alkyl, or arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl; and R 7 is hydrogen or C 1-6 alkyl; R 8 is C 1-6 alkyl, C 1-6 alkylcarbonyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; and R 9 is di(C 1-6 alkyl)aminoC 1-6 alkyl; R 6 is -CHO, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, C 1-6 alkylcarbonylaminoC 1-6 alkyl, piperidinylC 1-6 alkyl, piperidinylC 1-6 alkylaminocarbonyl, C 1-6 alkyloxy, C 1-6 alkyloxyC 1-6 alkyl, thienylC 1-6 alkyl, pyrrolylC 1-6 alkyl, arylC 1-6 alkylpiperidinyl, arylcarbonylC 1-6 alkyl, arylcarbonylpiperidinylC 1-6 alkyl, haloindazolylpiperidinylC 1-6 alkyl, or arylC 1-6 alkyl(C 1-6 alkyl)aminoC 1-6 alkyl; and R 7 is hydrogen or C 1-6 alkyl; R 8 is C 1-6 alkyl, C 1-6 alkylcarbonyl or di(C 1-6 alkyl)aminoC 1-6 alkyl; and R 9 is di(C 1-6 alkyl)aminoC 1-6 alkyl; or R 3 is a group of formula -(CH 2) t -Z- (b-1), wherein t is 0, 1 or 2; Z is a heterocyclic ring system selected from wherein each R 10 independently is hydrogen, C 1-6 alkyl, aminocarbonyl, hydroxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, di(phenylC 2-6 alkenyl), piperidinylC 1-6 alkyl, C 1-10 cycloalkyl, C 1-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, morpholino, C 1-6 alkylimidazolyl, or pyridinylC 1-6 alkylamino; each R 11 independently is hydrogen, hydroxy, piperidinyl or aryl; t is 0, 1 or 2; Z is a heterocyclic ring system selected from wherein each R 10 independently is hydrogen, C 1-6 alkyl, aminocarbonyl, hydroxy, C 1-6 alkyloxyC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkylamino, di(phenylC 2-6 alkenyl), piperidinylC 1-6 alkyl, C 1-10 cycloalkyl, C 1-10 cycloalkylC 1-6 alkyl, aryloxy(hydroxy)C 1-6 alkyl, haloindazolyl, arylC 1-6 alkyl, arylC 2-6 alkenyl, morpholino, C 1-6 alkylimidazolyl, or pyridinylC 1-6 alkylamino; each R 11 independently is hydrogen, hydroxy, piperidinyl or aryl;