A drug delivery system comprising: a drug delivery device (602, 700, 800, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400 2500, 2600, 2700, 2800, 2900, 3000, 3100) comprising a reservoir (604, 650, 712, 840, 1710, 1810, 1910, 2010, 2110, 2210, 2310, 2410, 2510, 2610, 2710, 2810, 2910), a delivery cannula (610, 652, 714, 844, 892, 1712, 1812, 1862, 1912, 2012, 2112, 2312, 2412, 2512, 2612, 2712, 2812, 2912) having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and a removable sterile barrier disposed over or about the distal end of the delivery cannula; one or more sensors (632, 3162) coupled to the drug delivery device and configured to detect movement of the removable sterile barrier (626, 830, 1750, 1850, 1950, 2050, 2150, 2250, 2350, 2450, 2550, 2850, 3120); a wireless transmitter (352, 752, 902, 1772, 1872, 1972, 2072, 2172, 2272, 2372, 2472, 2572, 2672, 2772, 2872, 2972); and a controller (350, 750, 900, 1700, 1770, 1870, 1970, 2070, 2170, 2270, 2370, 2470, 2570, 2670, 2770, 2870, 2970) coupled to the one or more sensors and the wireless transmitter, characterized in that the controller is configured to: initiate a sterility check and as part of the sterility check use the one or more sensors to determine if the removable sterile barrier has been removed from the drug delivery device, and control the wireless transmitter to wirelessly transmit a report representative of removal of the removable sterile barrier if the removable sterile barrier has been removed from the drug delivery device. a drug delivery device (602, 700, 800, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400 2500, 2600, 2700, 2800, 2900, 3000, 3100) comprising a reservoir (604, 650, 712, 840, 1710, 1810, 1910, 2010, 2110, 2210, 2310, 2410, 2510, 2610, 2710, 2810, 2910), a delivery cannula (610, 652, 714, 844, 892, 1712, 1812, 1862, 1912, 2012, 2112, 2312, 2412, 2512, 2612, 2712, 2812, 2912) having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and a removable sterile barrier disposed over or about the distal end of the delivery cannula; one or more sensors (632, 3162) coupled to the drug delivery device and configured to detect movement of the removable sterile barrier (626, 830, 1750, 1850, 1950, 2050, 2150, 2250, 2350, 2450, 2550, 2850, 3120); a wireless transmitter (352, 752, 902, 1772, 1872, 1972, 2072, 2172, 2272, 2372, 2472, 2572, 2672, 2772, 2872, 2972); and a controller (350, 750, 900, 1700, 1770, 1870, 1970, 2070, 2170, 2270, 2370, 2470, 2570, 2670, 2770, 2870, 2970) coupled to the one or more sensors and the wireless transmitter, characterized in that the controller is configured to: initiate a sterility check and as part of the sterility check use the one or more sensors to determine if the removable sterile barrier has been removed from the drug delivery device, and control the wireless transmitter to wirelessly transmit a report representative of removal of the removable sterile barrier if the removable sterile barrier has been removed from the drug delivery device. initiate a sterility check and as part of the sterility check use the one or more sensors to determine if the removable sterile barrier has been removed from the drug delivery device, and control the wireless transmitter to wirelessly transmit a report representative of removal of the removable sterile barrier if the removable sterile barrier has been removed from the drug delivery device.