A system configured to in-exsufflate a subject, the system comprising; a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject; a delivery circuit including a conduit and being configured to guide the pressurized flow of breathable gas to the airway of the subject; one or more sensors configured to generate one or more output signals conveying information related to one or more parameters, wherein the one or more parameters include a respiratory parameter; and one or more processors configured to execute computer program modules, the computer program modules comprising: a control module configured to control the pressure generator to inexsufflate the subject; and a parameter determination module configured to determine a peak cough flow parameter and an inspiratory tidal volume based on the one or more output signals, wherein the determination of the peak cough flow parameter includes compensation (i) for a length of the conduit between a particular one of the one or more sensors and the airway of the subject and/or (ii) for a volume of the breathable gas within one or more components of the delivery circuit disposed between a particular one of the one or more sensors and the airway of the subject, wherein the control module is configured to use, in a feedback manner, the peak cough flow parameter of one or more recent inexsufflations determined by the parameter determination module and the inspiratory tidal volume determined by the parameter determination module to adjust one or more gas parameters of the pressurized flow of breathable gas such that a target peak cough flow for individual inexsufflations and a target inspiratory tidal volume for individual inexsufflations are reached. a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject; a delivery circuit including a conduit and being configured to guide the pressurized flow of breathable gas to the airway of the subject; one or more sensors configured to generate one or more output signals conveying information related to one or more parameters, wherein the one or more parameters include a respiratory parameter; and one or more processors configured to execute computer program modules, the computer program modules comprising: a control module configured to control the pressure generator to inexsufflate the subject; and a parameter determination module configured to determine a peak cough flow parameter and an inspiratory tidal volume based on the one or more output signals, wherein the determination of the peak cough flow parameter includes compensation (i) for a length of the conduit between a particular one of the one or more sensors and the airway of the subject and/or (ii) for a volume of the breathable gas within one or more components of the delivery circuit disposed between a particular one of the one or more sensors and the airway of the subject, wherein the control module is configured to use, in a feedback manner, the peak cough flow parameter of one or more recent inexsufflations determined by the parameter determination module and the inspiratory tidal volume determined by the parameter determination module to adjust one or more gas parameters of the pressurized flow of breathable gas such that a target peak cough flow for individual inexsufflations and a target inspiratory tidal volume for individual inexsufflations are reached. a control module configured to control the pressure generator to inexsufflate the subject; and a parameter determination module configured to determine a peak cough flow parameter and an inspiratory tidal volume based on the one or more output signals, wherein the determination of the peak cough flow parameter includes compensation (i) for a length of the conduit between a particular one of the one or more sensors and the airway of the subject and/or (ii) for a volume of the breathable gas within one or more components of the delivery circuit disposed between a particular one of the one or more sensors and the airway of the subject, wherein the control module is configured to use, in a feedback manner, the peak cough flow parameter of one or more recent inexsufflations determined by the parameter determination module and the inspiratory tidal volume determined by the parameter determination module to adjust one or more gas parameters of the pressurized flow of breathable gas such that a target peak cough flow for individual inexsufflations and a target inspiratory tidal volume for individual inexsufflations are reached.