A portable clinical system for in vitro analysis, the system comprising: a test device configured to perform an analytical test; an analyzer comprising: a port configured to receive the test device; and a computing device configured to: initiate a test cycle of the test device to perform the analytical test; determine spatial orientation and motion of the analyzer during the test cycle of the test device; compare the determined spatial orientation to a threshold operating spatial plane for the test device; compare the determined motion to a threshold rate of motion for the test device; and correct a result of the analytical test when at least one of: (i) the determined spatial orientation exceeds the threshold operating spatial plane, and/or (ii) the determined motion exceeds the threshold rate of motion, wherein the correcting the result comprises applying a correction factor to the result; and a processor configured to determine the correction factor to be applied to the result of the analytical test for the determined spatial orientation or the determined motion of the analyzer. a test device configured to perform an analytical test; an analyzer comprising: a port configured to receive the test device; and a computing device configured to: initiate a test cycle of the test device to perform the analytical test; determine spatial orientation and motion of the analyzer during the test cycle of the test device; compare the determined spatial orientation to a threshold operating spatial plane for the test device; compare the determined motion to a threshold rate of motion for the test device; and correct a result of the analytical test when at least one of: (i) the determined spatial orientation exceeds the threshold operating spatial plane, and/or (ii) the determined motion exceeds the threshold rate of motion, wherein the correcting the result comprises applying a correction factor to the result; and a port configured to receive the test device; and a computing device configured to: initiate a test cycle of the test device to perform the analytical test; determine spatial orientation and motion of the analyzer during the test cycle of the test device; compare the determined spatial orientation to a threshold operating spatial plane for the test device; compare the determined motion to a threshold rate of motion for the test device; and correct a result of the analytical test when at least one of: (i) the determined spatial orientation exceeds the threshold operating spatial plane, and/or (ii) the determined motion exceeds the threshold rate of motion, wherein the correcting the result comprises applying a correction factor to the result; and initiate a test cycle of the test device to perform the analytical test; determine spatial orientation and motion of the analyzer during the test cycle of the test device; compare the determined spatial orientation to a threshold operating spatial plane for the test device; compare the determined motion to a threshold rate of motion for the test device; and correct a result of the analytical test when at least one of: (i) the determined spatial orientation exceeds the threshold operating spatial plane, and/or (ii) the determined motion exceeds the threshold rate of motion, wherein the correcting the result comprises applying a correction factor to the result; and