A brake control system for a vehicle comprising: a master pressure controller, having a first brake operation quantity sensor for detecting a brake operation quantity, for controlling a first driving motor that pressurizes working fluid of a master cylinder so as to increase a wheel cylinder pressure of each of the wheels of said vehicle; and a wheel pressure controller connected to said master pressure controller through a communication line, for executing a different control from that of said master pressure controller for controlling a second driving motor to increase the wheel cylinder pressure of each of the wheels, said wheel pressure controller having a second brake operation quantity sensor for detecting said brake operation quantity, said wheel pressure controller further includes a failure judgment unit for judging failure of said master pressure controller based on a failure information sent from said master pressure controller via said communication line or a detection result sent from a failure detection unit of the master pressure controller, said failure detection unit detecting a failure of a communication between said wheel pressure controller and said master pressure controller via said communication line, and a wheel cylinder pressure control unit for controlling a wheel cylinder pressure of each wheel by increasing the wheel cylinder pressure with said second driving motor, based on the brake operation quantity detected by said second brake operation quantity sensor when said failure judgment unit judges the failure of said master pressure controller, wherein said master pressure controller stops controlling of said first driving motor upon a transmission of said failure information, or upon a failure of communication between said master pressure controller and said wheel pressure controller via said communication line. a master pressure controller, having a first brake operation quantity sensor for detecting a brake operation quantity, for controlling a first driving motor that pressurizes working fluid of a master cylinder so as to increase a wheel cylinder pressure of each of the wheels of said vehicle; and a wheel pressure controller connected to said master pressure controller through a communication line, for executing a different control from that of said master pressure controller for controlling a second driving motor to increase the wheel cylinder pressure of each of the wheels, said wheel pressure controller having a second brake operation quantity sensor for detecting said brake operation quantity, said wheel pressure controller further includes a failure judgment unit for judging failure of said master pressure controller based on a failure information sent from said master pressure controller via said communication line or a detection result sent from a failure detection unit of the master pressure controller, said failure detection unit detecting a failure of a communication between said wheel pressure controller and said master pressure controller via said communication line, and a wheel cylinder pressure control unit for controlling a wheel cylinder pressure of each wheel by increasing the wheel cylinder pressure with said second driving motor, based on the brake operation quantity detected by said second brake operation quantity sensor when said failure judgment unit judges the failure of said master pressure controller, wherein said master pressure controller stops controlling of said first driving motor upon a transmission of said failure information, or upon a failure of communication between said master pressure controller and said wheel pressure controller via said communication line.