A compound of formula or an N -oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, or a glucuronide derivative thereof, or a co-crystal thereof: wherein E represents -CH 2 -; Q represents -CH 2 - or -CH 2 O-; Z represents hydrogen; or Z represents C 1-6 alkyl or heteroaryl, either of which groups may be optionally substituted by one, two or three substituents independently selected from halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, oxo, hydroxy, hydroxy(C 1-6)alkyl, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-3 alkylenedioxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, di(C 1-6)alkylamino(C 1-6)alkyl, C 2-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6)alkylaminocarbonyl, aminosulfonyl, C 1-6 alkylaminosulfonyl, di(C 1-6)alkylaminosulfonyl, aminocarbonylamino and hydrazinocarbonyl; R 3 represents -CONR b R c; or R 3 represents heteroaryl, which group may be optionally substituted by one or two substituents independently selected from di(C 1 - 6)alkylamino; R 11 represents hydrogen; R 15 represents halogen or difluoromethoxy; R 16 represents hydrogen or halogen; and R b and R c, when taken together with the nitrogen atom to which they are both attached, represent azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl or homopiperazin-1-yl; and the heteroaryl groups referred to above are independently selected from furyl, benzofuryl, dibenzofuryl, thienyl, benzothienyl, thieno[2,3- c]pyrazolyl, thieno[3,4- b][1,4]-dioxinyl, dibenzothienyl, pyrrolyl, indolyl, pyrrolo[2,3- b]pyridinyl, pyrrolo[3,2- c]-pyridinyl, pyrrolo[3,4- b]pyridinyl, pyrazolyl, pyrazolo[1,5- a]pyridinyl, pyrazolo[3,4- d]-pyrimidinyl, indazolyl, 4,5,6,7-tetrahydroindazolyl, oxazolyl, benzoxazolyl, isoxazolyl, thiazolyl, benzothiazolyl, isothiazolyl, imidazolyl, benzimidazolyl, imidazo[2,1-b]-thiazolyl, imidazo[1,2- a]pyridinyl, imidazo[4,5- b]pyridinyl, purinyl, imidazo[1,2- a]-pyrimidinyl, imidazo[1,2- a]pyrazinyl, oxadiazolyl, thiadiazolyl, triazolyl, [1,2,4]triazolo-[1,5- a]pyrimidinyl, benzotriazolyl, tetrazolyl, pyridinyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyridazinyl, cinnolinyl, phthalazinyl, pyrimidinyl, quinazolinyl, pyrazinyl, quinoxalinyl, pteridinyl, triazinyl and chromenyl. E represents -CH 2 -; Q represents -CH 2 - or -CH 2 O-; Z represents hydrogen; or Z represents C 1-6 alkyl or heteroaryl, either of which groups may be optionally substituted by one, two or three substituents independently selected from halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, oxo, hydroxy, hydroxy(C 1-6)alkyl, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-3 alkylenedioxy, C 1-6 alkylthio, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, amino, C 1-6 alkylamino, di(C 1-6)alkylamino, di(C 1-6)alkylamino(C 1-6)alkyl, C 2-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, formyl, C 2-6 alkylcarbonyl, carboxy, C 2-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, di(C 1-6)alkylaminocarbonyl, aminosulfonyl, C 1-6 alkylaminosulfonyl, di(C 1-6)alkylaminosulfonyl, aminocarbonylamino and hydrazinocarbonyl; R 3 represents -CONR b R c; or R 3 represents heteroaryl, which group may be optionally substituted by one or two substituents independently selected from di(C 1 - 6)alkylamino; R 11 represents hydrogen; R 15 represents halogen or difluoromethoxy; R 16 represents hydrogen or halogen; and R b and R c, when taken together with the nitrogen atom to which they are both attached, represent azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl or homopiperazin-1-yl; and the heteroaryl groups referred to above are independently selected from furyl, benzofuryl, dibenzofuryl, thienyl, benzothienyl, thieno[2,3- c]pyrazolyl, thieno[3,4- b][1,4]-dioxinyl, dibenzothienyl, pyrrolyl, indolyl, pyrrolo[2,3- b]pyridinyl, pyrrolo[3,2- c]-pyridinyl, pyrrolo[3,4- b]pyridinyl, pyrazolyl, pyrazolo[1,5- a]pyridinyl, pyrazolo[3,4- d]-pyrimidinyl, indazolyl, 4,5,6,7-tetrahydroindazolyl, oxazolyl, benzoxazolyl, isoxazolyl, thiazolyl, benzothiazolyl, isothiazolyl, imidazolyl, benzimidazolyl, imidazo[2,1-b]-thiazolyl, imidazo[1,2- a]pyridinyl, imidazo[4,5- b]pyridinyl, purinyl, imidazo[1,2- a]-pyrimidinyl, imidazo[1,2- a]pyrazinyl, oxadiazolyl, thiadiazolyl, triazolyl, [1,2,4]triazolo-[1,5- a]pyrimidinyl, benzotriazolyl, tetrazolyl, pyridinyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyridazinyl, cinnolinyl, phthalazinyl, pyrimidinyl, quinazolinyl, pyrazinyl, quinoxalinyl, pteridinyl, triazinyl and chromenyl.