A compound of formula: wherein: R and R 0 are independently selected from hydrogen and hydroxyl; n is 1; Y and Y' together is double-bonded oxygen; R 1, R 2, R 3 and R 4 are independently selected from hydrogen, halogen, alkyl, trifluoromethyl and alkoxy; R 7 and R 8 are independently selected from hydrogen, alkyl, trifluoromethyl and alkoxy; R 14 is hydroxyl, or a cleavable alcohol prodrug moiety of the formula Q-U- wherein U is selected from the group consisting of oxygen and OCH 2; and Q is selected from the group consisting of PEG-CO, HCO, acetyl, amino acid moiety, substituted benzoic acid moiety and phosphoric acid moiety; or, wherein Q-U together is selected from phosphonooxy, phosphonoalkyloxy, formyloxy, alkylcarbonyloxy, alkylcarbonyloxyalkyloxy, aminocarbonyloxyalkyloxy, alkylsulfonyloxy, alkylsulfinyloxy, carbamate, arylcarbonyloxy, arylalkylcarbonyloxy, aryloxycarbonyloxy, heterocyclylcarbonyloxy and heterocyclylalkylcarbonyloxy; R 12, R 13, R 15 and R 16 are independently selected from hydrogen, halogen, alkyl, trifluoromethyl, hydroxyl, alkoxy, formyloxy, alkylcarbonyloxy, hydroxyalkyl, aldehyde, amino, alkylamino, aminoalkyl, alkylaminoalkyl, dialkylamino, mercapto, azido, and substituted or unsubstituted groups selected from alkylsulfinyloxy, alkylsulfonyloxy, carbamate, carbamido, and sulfonamido, or any two of R 12, R 13, R 15 and R 16 form an alkylenedioxy group; X is NR'R", where R' is furanyl or furanylalkyl wherein the furanyl of the furanyl or furanylalkyl is optionally substituted with one or more of halo, alkyl, trifluoromethyl, hydroxyl, alkoxy, amino, alkylamino, dialkylamino, mercapto, alkylmercapto, carboxamido, aldehyde, cyano, oxo, alkylcarbonyloxy, and sulfonamido; and R" is selected from hydrogen, alkyl, hydroxyalkyl, aminoalkyl, dialkylaminoalkyl, cyanoalkyl, haloalkyl, alkylcarbonylalkylcarbonyloxy, pyridyl, and COR 11 wherein R 11 is selected from hydrogen, trifluoromethyl, alkylmercapto, and aryl; or a pharmaceutically acceptable salt thereof. R and R 0 are independently selected from hydrogen and hydroxyl; n is 1; Y and Y' together is double-bonded oxygen; R 1, R 2, R 3 and R 4 are independently selected from hydrogen, halogen, alkyl, trifluoromethyl and alkoxy; R 7 and R 8 are independently selected from hydrogen, alkyl, trifluoromethyl and alkoxy; R 14 is hydroxyl, or a cleavable alcohol prodrug moiety of the formula Q-U- wherein U is selected from the group consisting of oxygen and OCH 2; and Q is selected from the group consisting of PEG-CO, HCO, acetyl, amino acid moiety, substituted benzoic acid moiety and phosphoric acid moiety; or, wherein Q-U together is selected from phosphonooxy, phosphonoalkyloxy, formyloxy, alkylcarbonyloxy, alkylcarbonyloxyalkyloxy, aminocarbonyloxyalkyloxy, alkylsulfonyloxy, alkylsulfinyloxy, carbamate, arylcarbonyloxy, arylalkylcarbonyloxy, aryloxycarbonyloxy, heterocyclylcarbonyloxy and heterocyclylalkylcarbonyloxy; R 12, R 13, R 15 and R 16 are independently selected from hydrogen, halogen, alkyl, trifluoromethyl, hydroxyl, alkoxy, formyloxy, alkylcarbonyloxy, hydroxyalkyl, aldehyde, amino, alkylamino, aminoalkyl, alkylaminoalkyl, dialkylamino, mercapto, azido, and substituted or unsubstituted groups selected from alkylsulfinyloxy, alkylsulfonyloxy, carbamate, carbamido, and sulfonamido, or any two of R 12, R 13, R 15 and R 16 form an alkylenedioxy group; X is NR'R", where R' is furanyl or furanylalkyl wherein the furanyl of the furanyl or furanylalkyl is optionally substituted with one or more of halo, alkyl, trifluoromethyl, hydroxyl, alkoxy, amino, alkylamino, dialkylamino, mercapto, alkylmercapto, carboxamido, aldehyde, cyano, oxo, alkylcarbonyloxy, and sulfonamido; and R" is selected from hydrogen, alkyl, hydroxyalkyl, aminoalkyl, dialkylaminoalkyl, cyanoalkyl, haloalkyl, alkylcarbonylalkylcarbonyloxy, pyridyl, and COR 11 wherein R 11 is selected from hydrogen, trifluoromethyl, alkylmercapto, and aryl; or a pharmaceutically acceptable salt thereof.