A combination of a disinfecting cap and a secondary medical device connector, the combination comprising a multiple start thread pattern in the disinfecting cap having a closed top and a female thread to interface with the secondary medical device connector having a complimentary male thread, the multiple start thread pattern comprising: a first start thread path (2140, 3040) on the inner surface of a cylindrical wall forming a cavity of the disinfecting cap, wherein the first start thread path has a first major profile, a first minor profile, a first pitch, and a first thread section profile; at least a second start thread path (2143, 3042) on said inner surface, wherein the second start thread path has a second major profile, a second minor profile, a second pitch, and a second thread section profile; wherein the first thread section profile and the second thread section profile are different, and wherein the complimentary male thread (13, 133) of the secondary medical device connector (9, 93) has a third major profile with a uniform outer diameter, a third minor profile, and a third pitch substantially equivalent to said first pitch, wherein the first start thread path and the second start thread path form the female thread pattern, the first and second start thread paths are configured to interface with said male thread, the first start thread path interfaces with the complimentary male thread to substantially engage the complimentary male thread, and when said first start thread path (2140, 3040) engages said complimentary male thread (13, 133) contacting said third major profile, a first helical void is formed by the space enclosed by the first start thread path (2140, 3040) and one of said third major profile and said third minor profile of the complimentary male thread (13, 133) for venting of said inner cavity during engagement. a first start thread path (2140, 3040) on the inner surface of a cylindrical wall forming a cavity of the disinfecting cap, wherein the first start thread path has a first major profile, a first minor profile, a first pitch, and a first thread section profile; at least a second start thread path (2143, 3042) on said inner surface, wherein the second start thread path has a second major profile, a second minor profile, a second pitch, and a second thread section profile; wherein the first thread section profile and the second thread section profile are different, and wherein the complimentary male thread (13, 133) of the secondary medical device connector (9, 93) has a third major profile with a uniform outer diameter, a third minor profile, and a third pitch substantially equivalent to said first pitch, wherein the first start thread path and the second start thread path form the female thread pattern, the first and second start thread paths are configured to interface with said male thread, the first start thread path interfaces with the complimentary male thread to substantially engage the complimentary male thread, and when said first start thread path (2140, 3040) engages said complimentary male thread (13, 133) contacting said third major profile, a first helical void is formed by the space enclosed by the first start thread path (2140, 3040) and one of said third major profile and said third minor profile of the complimentary male thread (13, 133) for venting of said inner cavity during engagement.