A compound Formula or Formula: or a form thereof, wherein: X is selected from the group consisting of O, NR x, and a bond; R x is selected from the group consisting of hydrogen and C 1-4 alkyl; B is heterocyclyl, wherein heterocyclyl is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, optionally substituted where allowed by available valences with 1, 2, 3, 4, or 5 R b substituents; R b is independently selected from the group consisting of halogen, C 1-4 alkyl, amino, C 1-4 alkyl-amino, (C 1-4 alkyl) 2 -amino, and C 3-6 cycloalkyl; R 1 is selected from the group consisting of heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 alkyl, heteroaryl-C 2-4 alkenyl, heteroaryl-amino, and heteroaryl-C 1-4 alkyl-amino, wherein heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, wherein heterocyclyl is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted where allowed by available valences with 1 or 2 R 1a substituents; and R 1a is independently selected from the group consisting of halogen, hydroxyl, cyano, C 1-4 alkyl, deutero-C 1-4 alkyl, halo-C 1-4 alkyl, amino, C 1-4 alkyl-amino, (C 1-4 alkyl) 2 -amino, C 1-4 alkoxy, deutero-C 1-4 alkoxy, and halo-C 1-4 alkoxy; wherein a form of the compound is selected from the group consisting of a salt, hydrate, solvate, racemate, enantiomer, diastereomer, tautomer, and mixtures thereof. X is selected from the group consisting of O, NR x, and a bond; R x is selected from the group consisting of hydrogen and C 1-4 alkyl; B is heterocyclyl, wherein heterocyclyl is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, optionally substituted where allowed by available valences with 1, 2, 3, 4, or 5 R b substituents; R b is independently selected from the group consisting of halogen, C 1-4 alkyl, amino, C 1-4 alkyl-amino, (C 1-4 alkyl) 2 -amino, and C 3-6 cycloalkyl; R 1 is selected from the group consisting of heteroaryl, heterocyclyl, phenyl, heteroaryl-C 1-4 alkyl, heteroaryl-C 2-4 alkenyl, heteroaryl-amino, and heteroaryl-C 1-4 alkyl-amino, wherein heteroaryl is a 3-7 membered monocyclic or 6-10 membered bicyclic ring system having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, or S, wherein heterocyclyl is a saturated or partially unsaturated 3-7 membered monocyclic, 6-10 membered bicyclic or 13-16 membered polycyclic ring system having 1, 2, or 3 heteroatom ring members independently selected from N, O, or S, and wherein each instance of phenyl, heteroaryl or heterocyclyl is optionally substituted where allowed by available valences with 1 or 2 R 1a substituents; and R 1a is independently selected from the group consisting of halogen, hydroxyl, cyano, C 1-4 alkyl, deutero-C 1-4 alkyl, halo-C 1-4 alkyl, amino, C 1-4 alkyl-amino, (C 1-4 alkyl) 2 -amino, C 1-4 alkoxy, deutero-C 1-4 alkoxy, and halo-C 1-4 alkoxy; wherein a form of the compound is selected from the group consisting of a salt, hydrate, solvate, racemate, enantiomer, diastereomer, tautomer, and mixtures thereof.