A compound of formula: or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, for use in a method for treatment, management or prevention of a cancer of the blood or bone marrow, wherein: R 1 is: hydrogen; halo; -(CH 2) n OH; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or - (CH 2) n NHR a, wherein R a is: hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; -(CH 2) n -(6 to 10 membered aryl); -C -(CH 2) n -(6 to 10 membered aryl) or -C -(CH 2) n -(6 to 10 membered heteroaryl), wherein the aryl or heteroaryl is optionally substituted with one or more of: halo; -SCF 3; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(C 1 -C 8)alkyl, wherein the alkyl is optionally substituted with one or more halo; -C -(CH 2) n -(C 3 -C 10 -cycloalkyl); -C -(CH 2) n -NR b R c, wherein R b and R c are each independently: hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or 6 to 10 membered aryl, optionally substituted with one or more of: halo; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(CH 2) n -O-(C 1 -C 6)alkyl; or -C -(CH 2) n -O-(CH 2) n -(6 to 10 membered aryl); R 2 is: hydrogen; -(CH 2) n OH; phenyl; -O-(C 1 -C 6)alkyl; or (C 1 -C 6)alkyl, optionally substituted with one or more halo; R 3 is: hydrogen; or (C 1 -C 6)alkyl, optionally substituted with one or more halo; and n is 0, 1, or 2. R 1 is: hydrogen; halo; -(CH 2) n OH; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or - (CH 2) n NHR a, wherein R a is: hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; -(CH 2) n -(6 to 10 membered aryl); -C -(CH 2) n -(6 to 10 membered aryl) or -C -(CH 2) n -(6 to 10 membered heteroaryl), wherein the aryl or heteroaryl is optionally substituted with one or more of: halo; -SCF 3; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(C 1 -C 8)alkyl, wherein the alkyl is optionally substituted with one or more halo; -C -(CH 2) n -(C 3 -C 10 -cycloalkyl); -C -(CH 2) n -NR b R c, wherein R b and R c are each independently: hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or 6 to 10 membered aryl, optionally substituted with one or more of: halo; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(CH 2) n -O-(C 1 -C 6)alkyl; or -C -(CH 2) n -O-(CH 2) n -(6 to 10 membered aryl); hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; -(CH 2) n -(6 to 10 membered aryl); -C -(CH 2) n -(6 to 10 membered aryl) or -C -(CH 2) n -(6 to 10 membered heteroaryl), wherein the aryl or heteroaryl is optionally substituted with one or more of: halo; -SCF 3; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(C 1 -C 8)alkyl, wherein the alkyl is optionally substituted with one or more halo; -C -(CH 2) n -(C 3 -C 10 -cycloalkyl); -C -(CH 2) n -NR b R c, wherein R b and R c are each independently: hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or 6 to 10 membered aryl, optionally substituted with one or more of: halo; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; hydrogen; (C 1 -C 6)alkyl, optionally substituted with one or more halo; (C 1 -C 6)alkoxy, optionally substituted with one or more halo; or 6 to 10 membered aryl, optionally substituted with one or more of: halo; (C 1 -C 6)alkyl, itself optionally substituted with one or more halo; or (C 1 -C 6)alkoxy, itself optionally substituted with one or more halo; -C -(CH 2) n -O-(C 1 -C 6)alkyl; or -C -(CH 2) n -O-(CH 2) n -(6 to 10 membered aryl); R 2 is: hydrogen; -(CH 2) n OH; phenyl; -O-(C 1 -C 6)alkyl; or (C 1 -C 6)alkyl, optionally substituted with one or more halo; R 3 is: hydrogen; or (C 1 -C 6)alkyl, optionally substituted with one or more halo; and n is 0, 1, or 2.