mhurhangee/ep-ind-claims huggingface dataset:
An ingestible device for delivery of a therapeutic agent into a lumen wall of a gastrointestinal tract of a patient, the device comprising: a capsule sized to pass through the intestinal tract; and a tissue penetrating member carried by the capsule and having a tissue penetration end, the tissue penetrating member formed from a solid therapeutic agent comprising at least one therapeutic agent, wherein the therapeutic agent would chemically degrade if released within the lumen of the gastrointestinal tract, the tissue penetrating member shaped and configured to be inserted into the lumen wall from the application of mechanical force of the tissue penetrating member from an actuator disposed within the capsule, wherein the tissue penetrating member releases the therapeutic agent into the blood stream from the lumen wall without substantial chemical degradation of the therapeutic agent in the lumen of the gastrointestinal tract. a capsule sized to pass through the intestinal tract; and a tissue penetrating member carried by the capsule and having a tissue penetration end, the tissue penetrating member formed from a solid therapeutic agent comprising at least one therapeutic agent, wherein the therapeutic agent would chemically degrade if released within the lumen of the gastrointestinal tract, the tissue penetrating member shaped and configured to be inserted into the lumen wall from the application of mechanical force of the tissue penetrating member from an actuator disposed within the capsule, wherein the tissue penetrating member releases the therapeutic agent into the blood stream from the lumen wall without substantial chemical degradation of the therapeutic agent in the lumen of the gastrointestinal tract.
A heat exchanger (112, 212) comprising: a fluid reservoir; a primary flow circuit (116, 216) defining a first flow path and comprising a pump (121, 221) and a Venturi tube (122, 222), the first flow path drawing fluid from the reservoir and returning the fluid to the reservoir, the Venturi tube having an inlet (122a, 222a) and an outlet (122b, 222b), the inlet and outlet being connected by a narrow waist region (122c, 222c); and a secondary flow circuit (123a,b; 124a-d; 223a,b; 224a-d) defining a secondary flow path, the secondary flow path drawing fluid from the reservoir and merging with the first flow path to return the fluid to the reservoir, at least a portion of the secondary flow circuit being arranged for thermal communication with an electronic device (111, 211); wherein the secondary flow circuit is in fluid communication with the narrow waist region of the Venturi tube, such that the Venturi tube provides means for reducing the pressure of the fluid in the portion of the secondary flow circuit to a value less than the pressure external to the circuit. a fluid reservoir; a primary flow circuit (116, 216) defining a first flow path and comprising a pump (121, 221) and a Venturi tube (122, 222), the first flow path drawing fluid from the reservoir and returning the fluid to the reservoir, the Venturi tube having an inlet (122a, 222a) and an outlet (122b, 222b), the inlet and outlet being connected by a narrow waist region (122c, 222c); and a secondary flow circuit (123a,b; 124a-d; 223a,b; 224a-d) defining a secondary flow path, the secondary flow path drawing fluid from the reservoir and merging with the first flow path to return the fluid to the reservoir, at least a portion of the secondary flow circuit being arranged for thermal communication with an electronic device (111, 211); wherein the secondary flow circuit is in fluid communication with the narrow waist region of the Venturi tube, such that the Venturi tube provides means for reducing the pressure of the fluid in the portion of the secondary flow circuit to a value less than the pressure external to the circuit.
A control device, comprising: a cyclic communication part configured to control communication of first control data (D01, D02, D1) of which arrival in a first guarantee time is guaranteed according to a preset cyclic period and second control data of which arrival in a second guarantee time longer than the cyclic period is guaranteed and of which a sequence of information included is determined; and a communication management part configured to manage a communication schedule of the first control data (D01, D02, D1) and the second control data, characterized in that, when new second control data is acquired while the second control data is divided into a plurality of communication data and communicated according to the cyclic period, wherein a communication target slave device for this new second control data is the same as that of the second control data, the communication management part determines a communication sequence of the plurality of second control data according to priorities of the plurality of second control data, and wherein, when a priority of the new second control data is higher than a priority of the second control data that is being communicated, the communication management part temporarily stops communication of the second control data that is being communicated and performs communication of the new second control data, and after communication of the new second control data is completed, the communication management part resumes communication of the second control data that is temporarily stopped. a cyclic communication part configured to control communication of first control data (D01, D02, D1) of which arrival in a first guarantee time is guaranteed according to a preset cyclic period and second control data of which arrival in a second guarantee time longer than the cyclic period is guaranteed and of which a sequence of information included is determined; and a communication management part configured to manage a communication schedule of the first control data (D01, D02, D1) and the second control data, characterized in that, when new second control data is acquired while the second control data is divided into a plurality of communication data and communicated according to the cyclic period, wherein a communication target slave device for this new second control data is the same as that of the second control data, the communication management part determines a communication sequence of the plurality of second control data according to priorities of the plurality of second control data, and wherein, when a priority of the new second control data is higher than a priority of the second control data that is being communicated, the communication management part temporarily stops communication of the second control data that is being communicated and performs communication of the new second control data, and after communication of the new second control data is completed, the communication management part resumes communication of the second control data that is temporarily stopped.
A compound of Formula I: or a single enantiomer, a mixture of an enantiomeric pair, an individual diastereomer, a mixture of diastereomers, or a tautomeric form thereof; or a pharmaceutically acceptable salt thereof; wherein R 1 is -OR 6; R 2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl or heteroaryl; R 3 is -C R 7, -C OR 8, -C NR 9 R 10, -C(=NR 11)R 12, -P (OR 6) 2 or-C NHSO 2 R 21; X is N or CR 4; each of R 4 and R 5 is independently H, halogen, cyano, azido, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, heteroaryl, -OR 6, -C R 7, -C OR 8, - C NR 9 R 10, -C(=NR 11)R 12, -NHSO 2 R 13, -NR 14 R 15, -SO 3 R 17 or -SO 2 R 18, or R 4 and R 5 together with the two carbon atoms to which they are attached form a ring; L is NR 16; and each of R 6, R 7, R 8, R 9, R 10, R 11, R 12, R 13, R 14, R 15, R 16, R 17, R 18, R 19, R 20 and R 21 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkyl-cycloalkylene or cycloalkyl-alkylene, wherein each alkyl, aryl, arylalkyl, alkaryl, heteroaryl, alkenyl, alkynyl, cycloalkyl, heterocyclyl or alkyl-cycloalkyl is optionally substituted with one or more substituents independently selected from halo, cyano, nitro, -SR a, -S R a, -S 2 R a, -R a, -C R a, - C OR a, -C NR b R c, -C(NR a)NR b R c, -OR a, -OC R a, -OC OR a, -OC NR b R c, - OC(=NR a)NR b R c, -OS R a, -OS 2 R a, -OS NR b R c, -OS 2 NR b R c, -NR b R c, - NR a C R b, -NR a C OR b, -NR a C NR b R c, -NR a C(=NR d)NR b R c, -NR a S R b, - NR a S 2 R b, -NR a S R b R c, or -NR a S 2 R b R c; wherein R a, R b, R c, and R d are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted; or R b and R c together with the N atom to which they are attached form heterocyclyl or heteroaryl, each optionally substituted; or with one or more moieties selected from the group consisting of halogen, hydroxy, amino, alkylamino, arylamino, alkoxy, aryloxy, nitro, cyano, sulfonic acid, sulfate, phosphonic acid, phosphate, or phosphonate.
A lower-leg orthosis with a splint for the immobilization of the muscles of the lower leg, the splint being formed by a lower-leg cuff and a foot rest connected with the lower-leg cuff, a foot device is arranged below the foot rest, via which the foot rest is supported on the ground, the foot device comprising a ground contact surface and an elastic energy reservoir arranged between the foot rest and the ground contact surface, wherein the energy reservoir serves for a cyclic energy storage and energy feedback during walking, characterized in that via the elastic energy reservoir of the foot device, torques can be transferred from the foot rest to the ground contact surface.
A gas turbine engine comprising: a compressor discharge casing; a combustor; a fuel nozzle placed in an end of the combustor; an annular passage formed in a sleeve of the combustor and configured to receive an air flow from the compressor discharge casing and to enable the air flow in a substantially axial direction, wherein the passage directs the air flow into a chamber downstream of the nozzle and wherein a chamber pressure is lower than a compressor discharge casing pressure; and a flow control device configured to selectively control the air flow from the compressor discharge casing directly into the passage based on an operation condition of the turbine engine, characterized in that the flow control device is configured to increase the flow of air during a turndown condition and to decrease the flow of air during a full load condition. a compressor discharge casing; a combustor; a fuel nozzle placed in an end of the combustor; an annular passage formed in a sleeve of the combustor and configured to receive an air flow from the compressor discharge casing and to enable the air flow in a substantially axial direction, wherein the passage directs the air flow into a chamber downstream of the nozzle and wherein a chamber pressure is lower than a compressor discharge casing pressure; and a flow control device configured to selectively control the air flow from the compressor discharge casing directly into the passage based on an operation condition of the turbine engine, characterized in that the flow control device is configured to increase the flow of air during a turndown condition and to decrease the flow of air during a full load condition.
A brown out detector (BOD, 10) for minimized power consumption and optimized response times, comprising: at least one track module configured to receive a supply voltage and output a tracked reference voltage; at least one sample module configured to receive a reference voltage and output a sampled reference voltage based on the reference voltage; at least one detector module configured to monitor the supply voltage, to detect a falling flank in the supply voltage and to output a boost current when the supply voltage falls beyond a predetermined threshold; and at least one comparator configured to compare the tracked reference voltage with the sampled reference voltage, to receive the boost current provided by the detector module and to output a BOD reset if the tracked reference voltage is less than the sampled reference voltage; wherein the at least one detector module is configured to generate the boost current when the falling flank in the supply voltage is detected by the detector module. at least one track module configured to receive a supply voltage and output a tracked reference voltage; at least one sample module configured to receive a reference voltage and output a sampled reference voltage based on the reference voltage; at least one detector module configured to monitor the supply voltage, to detect a falling flank in the supply voltage and to output a boost current when the supply voltage falls beyond a predetermined threshold; and at least one comparator configured to compare the tracked reference voltage with the sampled reference voltage, to receive the boost current provided by the detector module and to output a BOD reset if the tracked reference voltage is less than the sampled reference voltage; wherein the at least one detector module is configured to generate the boost current when the falling flank in the supply voltage is detected by the detector module.
A system for treating myocardial MVO comprising: a catheter having a distal end and a proximal end, an occlusion balloon disposed near the distal end, and at least one pressure sensor configured to generate sensor data corresponding to at least one of pressure values inside the distal end and pressure values outside the catheter distal to the occlusion balloon; a controller coupled to the at least one pressure sensor and configured to output commands in response to the sensor data; a pump assembly having at least one fluid reservoir containing a therapeutic injectate and an injector connected to the proximal end of the catheter to force injectate from the reservoir through the catheter, wherein the pump assembly forces injectate through the catheter at a flow rate responsive to the commands from the controller during a cycle while the occlusion balloon is inflated, wherein the commands from the controller instruct the pump assembly to execute an infusion waveform representing a flow pattern; characterized in that the commands from the controller instruct the pump assembly to reduce the flow rate to zero for a time period during the cycle to allow compression of microvasculature caused by natural myocardial contraction to draw the injectate into occluded myocardial vessels to promote mixing of the injectate with obstructing matter causing MVO. a catheter having a distal end and a proximal end, an occlusion balloon disposed near the distal end, and at least one pressure sensor configured to generate sensor data corresponding to at least one of pressure values inside the distal end and pressure values outside the catheter distal to the occlusion balloon; a controller coupled to the at least one pressure sensor and configured to output commands in response to the sensor data; a pump assembly having at least one fluid reservoir containing a therapeutic injectate and an injector connected to the proximal end of the catheter to force injectate from the reservoir through the catheter, wherein the pump assembly forces injectate through the catheter at a flow rate responsive to the commands from the controller during a cycle while the occlusion balloon is inflated, wherein the commands from the controller instruct the pump assembly to execute an infusion waveform representing a flow pattern; characterized in that the commands from the controller instruct the pump assembly to reduce the flow rate to zero for a time period during the cycle to allow compression of microvasculature caused by natural myocardial contraction to draw the injectate into occluded myocardial vessels to promote mixing of the injectate with obstructing matter causing MVO.
The use of a SPARC family polynucleotide encoding a SPARC family polypeptide with the sequence of SEQ ID NO: 1 in the preparation of a medicament for increasing the sensitivity or reducing the resistance of a mammal diagnosed with cancer to a therapeutic treatment for cancer wherein said mammal exhibits resistance to said therapeutic treatment.
An aircraft comprising a fixed wing airframe equipped with a pair of contra-rotatable rotors spaced transversely of the aircraft to provide forward thrust for wing-borne flight; means for controlling the collective and cyclic pitch of the blades of said rotors; and means (10, 11) by which the aircraft can stand on the ground with the chord direction of said wing and the axes of rotation of said rotors pointing upwards; whereby the aircraft is capable of vertical take off and landing and flight as a helicopter under lift produced by said rotors, capable of wing-borne flight under thrust produced by said rotors, and capable of transition between such helicopter and wing-borne flight without tilting of said rotor axes relative to said wing or tilting of said wing relative to any other airframe features if any other airframe features are provided; and wherein in planform said wing comprises, to each side of its longitudinal axis, an inner section with a swept back leading edge and an outer section with a leading edge which is swept back less than the leading edge of the inner section.
A method for the manufacture of structures on a substrate surface, said method comprising the steps of: a) providing a reaction solution, said reaction solution comprising a silicate, a micelle forming agent, an alkane, a salt, and at least 1.4 M HCI, said reaction solution having a pH of 2 or lower, b) stirring the reaction solution for not more than 10 minutes, c) bringing the reaction solution into contact with said substrate surface d) treating the obtained material to remove said micelle forming agent with one method selected from i) heat treating the material above 300 °C, ii) treating the material with at least one selected from H 2 O 2, and H 2 SO 4, and iii) treating the material with microwaves to digest the micelle forming agent, e) wherein the alkane is at least one selected from the group consisting of pentane, hexane, heptane, octane, nonane, decane, undecane, and dodecane. a) providing a reaction solution, said reaction solution comprising a silicate, a micelle forming agent, an alkane, a salt, and at least 1.4 M HCI, said reaction solution having a pH of 2 or lower, b) stirring the reaction solution for not more than 10 minutes, c) bringing the reaction solution into contact with said substrate surface d) treating the obtained material to remove said micelle forming agent with one method selected from i) heat treating the material above 300 °C, ii) treating the material with at least one selected from H 2 O 2, and H 2 SO 4, and iii) treating the material with microwaves to digest the micelle forming agent, e) wherein the alkane is at least one selected from the group consisting of pentane, hexane, heptane, octane, nonane, decane, undecane, and dodecane.
A vehicle speed determination system for a vehicle, such as a saddle, saddled or straddle-type vehicle or motorcycle, having a front wheel and a rear wheel, the vehicle speed determination system comprising: a first wheel speed sensor configured to detect a wheel speed (V f) of the front wheel; and an arithmetic section for determining a calculated or expected vehicle speed (V(r)) at a rear-wheel tangential point (r), based on a difference or expected difference in vehicle speed between a front-wheel tangential point (f) and the rear-wheel tangential point (r) that occurs due to a difference between a locus of travel of the front wheel and a locus of travel of the rear wheel, and based on the wheel speed (V f) of the front wheel; wherein the arithmetic section is configured to determine the difference or expected difference in vehicle speed between the front-wheel tangential point (f) and the rear-wheel tangential point (r) based on a yaw rate (ω z) of the vehicle. a first wheel speed sensor configured to detect a wheel speed (V f) of the front wheel; and an arithmetic section for determining a calculated or expected vehicle speed (V(r)) at a rear-wheel tangential point (r), based on a difference or expected difference in vehicle speed between a front-wheel tangential point (f) and the rear-wheel tangential point (r) that occurs due to a difference between a locus of travel of the front wheel and a locus of travel of the rear wheel, and based on the wheel speed (V f) of the front wheel; wherein the arithmetic section is configured to determine the difference or expected difference in vehicle speed between the front-wheel tangential point (f) and the rear-wheel tangential point (r) based on a yaw rate (ω z) of the vehicle.
The use of a composition including at least one tricyclic 3,4-propinoperhydropurine selected from GTX-2 and GTX-3, and a pharmacologically acceptable carrier, for the manufacture of a medicament for treatment of at least one ailment selected from fibromyalgia, joint pain, post-operative pain, neck pain, back pain, and tension headache.
A computer-implemented method comprising: obtaining i) a first plurality of feature vectors associated with a first image and ii) a second plurality of feature vectors associated with a second image; generating a plurality of transformed feature vectors by transforming each respective feature vector of the first plurality of feature vectors by a symmetric and positive definite kernel matrix trained to define an elliptical inner product space; generating a cost volume by determining, for each respective transformed feature vector of the plurality of transformed feature vectors, a plurality of inner products, wherein each respective inner product of the plurality of inner products is between the respective transformed feature vector and a corresponding candidate feature vector of a corresponding subset of the second plurality of feature vectors; and determining, based on the cost volume, a pixel correspondence between the first image and the second image. obtaining i) a first plurality of feature vectors associated with a first image and ii) a second plurality of feature vectors associated with a second image; generating a plurality of transformed feature vectors by transforming each respective feature vector of the first plurality of feature vectors by a symmetric and positive definite kernel matrix trained to define an elliptical inner product space; generating a cost volume by determining, for each respective transformed feature vector of the plurality of transformed feature vectors, a plurality of inner products, wherein each respective inner product of the plurality of inner products is between the respective transformed feature vector and a corresponding candidate feature vector of a corresponding subset of the second plurality of feature vectors; and determining, based on the cost volume, a pixel correspondence between the first image and the second image.
Roller container with an open top side for transport and storage of loose goods, comprising a floor, two side walls, a front wall and a rear wall, and a cover system for covering the open top side of the container, wherein said cover system comprises two rotatable cover devices, wherein each cover device is rotatable between an open position in which the cover device lies against a side wall of the container, and a covering position in which a part of the open top side is covered, characterized in that the top side of each side wall is provided with a top tube which extends over almost the complete length of the container, and that each cover device comprises a U-shaped frame provided with a longitudinal part with head ends and two upright fixing legs, wherein said longitudinal part is arranged so as to be freely rotatable in the top tube of a side wall.