mhurhangee/ep-ind-claims huggingface dataset:
A system for facilitating biological communication between two or more microfluidic cell culture devices comprising: first and second microfluidic cell culture devices (900, 1000); a fluid collection device configured to collect a first discrete fluid volume from an output port (912, 1012) of the first microfluidic cell culture device comprising a microfluidic channel (910, 1010) including a first organ tissue, and to deposit a second discrete fluid volume comprising at least a portion of said first discrete fluid volume into an input port (916, 1016) of the second microfluidic cell culture device comprising a microfluidic channel (910, 1010) including a second organ tissue; and a movement system configured to be coupled to the fluid collection device and to move the fluid collection device into a desired position relative to the first microfluidic cell culture device or the second microfluidic cell culture device, wherein, when the fluid collection device is positioned in the desired position relative to the first microfluidic cell culture device, the fluid collection device collects the respective first discrete fluid volume from the first microfluidic cell culture device, and when the fluid collection device is positioned in the desired position relative to the second microfluidic cell culture device, the fluid collection device deposits the respective second discrete fluid volume into the second microfluidic cell culture device, wherein the respective second discrete fluid volume perfuses through the second microfluidic cell culture device. first and second microfluidic cell culture devices (900, 1000); a fluid collection device configured to collect a first discrete fluid volume from an output port (912, 1012) of the first microfluidic cell culture device comprising a microfluidic channel (910, 1010) including a first organ tissue, and to deposit a second discrete fluid volume comprising at least a portion of said first discrete fluid volume into an input port (916, 1016) of the second microfluidic cell culture device comprising a microfluidic channel (910, 1010) including a second organ tissue; and a movement system configured to be coupled to the fluid collection device and to move the fluid collection device into a desired position relative to the first microfluidic cell culture device or the second microfluidic cell culture device, wherein, when the fluid collection device is positioned in the desired position relative to the first microfluidic cell culture device, the fluid collection device collects the respective first discrete fluid volume from the first microfluidic cell culture device, and when the fluid collection device is positioned in the desired position relative to the second microfluidic cell culture device, the fluid collection device deposits the respective second discrete fluid volume into the second microfluidic cell culture device, wherein the respective second discrete fluid volume perfuses through the second microfluidic cell culture device.
A thermally conductive silicone potting composition, comprising a first part comprising: (a) a vinyl organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, (f) a catalyst, and a second part comprising: (b) a hydride organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, wherein the average particle diameter has been measured by the relevant method in accordance with the description. a first part comprising: (a) a vinyl organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, (f) a catalyst, and (a) a vinyl organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, (f) a catalyst, and a second part comprising: (b) a hydride organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, wherein the average particle diameter has been measured by the relevant method in accordance with the description. (b) a hydride organopolysiloxane, (c) an alumina filler having an average particle diameter which is greater than or equal to 0.1 μm and less than 3 μm, (d) an alumina and/or aluminium hydroxide filler having an average particle diameter which is greater than or equal to 3 μm and less than 15 μm, (e) an alumina filler having an average particle diameter which is greater than or equal to 15 μm and less than or equal to 100 μm, wherein the average particle diameter has been measured by the relevant method in accordance with the description.
A lock for a vehicle assembly, the lock comprising: a movably mounted first part including a first engagement surface which defines a swept volume as the first part moves; a second part mounted via one or more bearing surfaces so as to be rotatable about a pivot axis and including a second engagement surface, the second part being pivotally movable between: a locked condition, in which the second engagement surface is within a locking region of the swept volume for engagement with the first engagement surface to inhibit movement of the first part; an unlocked condition, in which the second engagement surface is outside of the locking region of the swept volume, wherein the one or more bearing surfaces define an effective bearing radius which is greater than the distance between the centre of mass of the second part and the pivot axis; and characterised in that the second part defines a generally circular peripheral surface which extends around the pivot axis of the second part and which defines the second engagement surface. a movably mounted first part including a first engagement surface which defines a swept volume as the first part moves; a second part mounted via one or more bearing surfaces so as to be rotatable about a pivot axis and including a second engagement surface, the second part being pivotally movable between: a locked condition, in which the second engagement surface is within a locking region of the swept volume for engagement with the first engagement surface to inhibit movement of the first part; an unlocked condition, in which the second engagement surface is outside of the locking region of the swept volume, wherein the one or more bearing surfaces define an effective bearing radius which is greater than the distance between the centre of mass of the second part and the pivot axis; and characterised in that the second part defines a generally circular peripheral surface which extends around the pivot axis of the second part and which defines the second engagement surface. a locked condition, in which the second engagement surface is within a locking region of the swept volume for engagement with the first engagement surface to inhibit movement of the first part; an unlocked condition, in which the second engagement surface is outside of the locking region of the swept volume, wherein the one or more bearing surfaces define an effective bearing radius which is greater than the distance between the centre of mass of the second part and the pivot axis; and characterised in that the second part defines a generally circular peripheral surface which extends around the pivot axis of the second part and which defines the second engagement surface.
A method of deforming a layer of granular medium, the method comprising a step of burying at least one flexible envelope comprising a variable internal volume at a predetermined depth in the granular medium, and a step of varying the internal volume of said envelope between a first volume and a second volume greater than the first volume so as to raise or lower the layer of granular medium above the envelope.
A tractor provided with an implement detection arrangement, wherein said tractor is provided with a linkage system for attaching the implement thereto, the linkage system comprising a lifting cylinder having a position and/or pressure sensor (409, 411) and wherein changes of position and/or pressure of the lifting cylinder are measured when the tractor accelerates and/or travels uneven ground to provide a first parameter and a comparison is made with a second parameter measured on said tractor to determine whether an implement is attached to the tractor, characterised in that the second parameter is determined by a position or pressure sensor of a suspension cylinder of a wheel suspension of the tractor.
Probehead of an NMR-MAS apparatus, which is introduced during operation at least in part into a cavity of a magnet system, which generates a homogeneous static magnetic field B 0 in a z -direction, wherein during operation of the NMR-MAS apparatus a measurement sample is located in the probehead, which has a rotation axis, wherein the rotation axis is tilted at an angle of θ > 0 in relation to the z- axis, lies in an xz plane, and wherein the angle θ can be adjusted by mechanical tilt around a tilt axis parallel to the y-axis in the interval θ target - α1 ≤ θ ≤ θ target + α2 around a target angle θ target with the adjustment angles α1, α2, and wherein z = 0 is defined as the point of intersection of the rotation axis with the z -axis at the adjusted angle θ = θ target, characterized in that the rotation axis has an unchangeable, fixed angular position relative to the probehead, that it is provided to adjust at least the part of the probehead inserted into the cavity by an angle α with -α1 ≤ α ≤ α2 relative to the z -axis, by mechanical rotation around the tilt axis by means of an adjustment mechanism of the NMR-MAS apparatus, that the cavity of the magnet system is an extended body, which is described by a set M of space points, wherein a set N consists of all subsets O (α) and the subsets O(α) are described by rotation around the angle α with -α1 ≤ α ≤ α2 around the tilt axis of the bodies arising from the set M, that a set P = ∩ N is the intersection of all bodies generated by rotation by an angle α with -α1 ≤ α ≤ α2 of the cavity of the magnet system, that the probehead has an outer contour K, which has an upper end at z = L1 and a lower end at z = -L2 and for which it applies, that K is a subset of P: K c P, wherein for all z with -L2 ≤ z ≤ L1 an intersection S( z) of the contour K exists parallel to the xy plane, and wherein the intersection S shows an extension Q in the x -direction, that at least one intersection S( z 1) with z 1 < 0 exists with an extension Q in the x -direction, wherein Q ( z 1) < Q, and that at least one intersection S( z 2) with z 2 > 0 exists with an extension Q ( z 2) in the x -direction wherein Q ( z 2) ≤ Q.
Heating system for a building, comprising at least a first heat recovery apparatus for recovering heat from a first heat source, a second heat recovery apparatus for recovering heat from a second heat source for heating the building, and a medium flow pipe assembly arranged in a flow connection with said first heat recovery apparatus and said second heat recovery apparatus, for circulating the same medium through at least the first heat recovery apparatus and the second heat recovery apparatus, characterized in that the first heat recovery apparatus is a multilayer cell assembly comprising at least a first cell (11 a) and a second cell (11 b), wherein operating temperature range of the second cell (11 b) is set below temperature range of the first cell (11 a), and that the first heat recovery apparatus comprises at least two or more steps for recovering heat from exhaust air from the building, wherein the first heat recovery apparatus is adapted to decrease temperature of the exhaust air in each step, and to decrease the moisture content of the exhaust air in at least the first step by condensing airborne water on a surface of the first heat recovery apparatus.
A method for providing an improved output of a nucleic acid sequencer, comprising: (a) obtaining deoxyribonucleic acid molecules from a sample of a subject; (b) tagging the individual deoxyribonucleic acid DNA molecules with a set of duplex tags, wherein each duplex tag differently tags complementary strands of a double-stranded DNA molecule of the DNA molecules in the sample to provide tagged strands; (c) using the nucleic acid sequencer to sequence the tagged strands to provide sequence reads; (d) using the sequence reads to determine a quantitative measure of individual DNA molecules for which both strands are detected; (e) using the sequence reads to determine a quantitative measure of individual DNA molecules for which only one strand is detected; and (f) using the quantitative measures determined in (d) and (e) to determine a total number of double-stranded DNA molecules in the sample, wherein the total number comprises individual DNA molecules for which neither DNA strand is detected, thereby providing the improved output of the nucleic acid sequencer. (a) obtaining deoxyribonucleic acid molecules from a sample of a subject; (b) tagging the individual deoxyribonucleic acid DNA molecules with a set of duplex tags, wherein each duplex tag differently tags complementary strands of a double-stranded DNA molecule of the DNA molecules in the sample to provide tagged strands; (c) using the nucleic acid sequencer to sequence the tagged strands to provide sequence reads; (d) using the sequence reads to determine a quantitative measure of individual DNA molecules for which both strands are detected; (e) using the sequence reads to determine a quantitative measure of individual DNA molecules for which only one strand is detected; and (f) using the quantitative measures determined in (d) and (e) to determine a total number of double-stranded DNA molecules in the sample, wherein the total number comprises individual DNA molecules for which neither DNA strand is detected, thereby providing the improved output of the nucleic acid sequencer.
A system (200, 300) for a bioprocess operation, comprising: an aseptic connector (112;300) having a first portion (310;482) and a second portion (320;484); a removable clamp (114;200) configured to secure the first portion (310;482) of the aseptic connector (112;300) to the second portion (320;484) of the aseptic connector, the system (200, 300) being characterised by: the aseptic connector (112;300) comprising a sensor, wherein the sensor is for measuring parameters of fluid flowing through the aseptic connector (112;300), the sensor being coupled to a sensor plug; wherein the removable clamp (114;200) comprises: a housing (222;410); a controller disposed within the housing; a rechargeable battery (240;420) disposed within the housing; a wireless radio (260;430) disposed within the housing; and a sensor plug receptacle (250;470) configured to receive the sensor plug; wherein the controller is configured to determine a sensor output of the sensor and to transmit the output using the wireless radio (260;430). an aseptic connector (112;300) having a first portion (310;482) and a second portion (320;484); a removable clamp (114;200) configured to secure the first portion (310;482) of the aseptic connector (112;300) to the second portion (320;484) of the aseptic connector, the system (200, 300) being characterised by: the aseptic connector (112;300) comprising a sensor, wherein the sensor is for measuring parameters of fluid flowing through the aseptic connector (112;300), the sensor being coupled to a sensor plug; wherein the removable clamp (114;200) comprises: a housing (222;410); a controller disposed within the housing; a rechargeable battery (240;420) disposed within the housing; a wireless radio (260;430) disposed within the housing; and a sensor plug receptacle (250;470) configured to receive the sensor plug; wherein the controller is configured to determine a sensor output of the sensor and to transmit the output using the wireless radio (260;430). a housing (222;410); a controller disposed within the housing; a rechargeable battery (240;420) disposed within the housing; a wireless radio (260;430) disposed within the housing; and a sensor plug receptacle (250;470) configured to receive the sensor plug; a controller disposed within the housing; a rechargeable battery (240;420) disposed within the housing; a wireless radio (260;430) disposed within the housing; and a sensor plug receptacle (250;470) configured to receive the sensor plug; wherein the controller is configured to determine a sensor output of the sensor and to transmit the output using the wireless radio (260;430).
An air conditioner selection system for selecting an air conditioner from a plurality of air conditioners each including an air conditioning unit, the air conditioner selection system comprising: a floor area acquisition section configured to acquire a floor area of a target space where the air conditioning unit is to be installed, characterized by: an allowable refrigerant amount acquisition section configured to acquire an allowable refrigerant amount which is amount of a refrigerant allowed to remain in the target space in a case where the refrigerant leaks out of the air conditioning unit into the target space at least based on the floor area acquired by the floor area acquisition section; an air conditioner selection section configured to select the air conditioner that includes the air conditioning unit installable in the target space at least based on the allowable refrigerant amount acquired by the allowable refrigerant amount acquisition section; and an air conditioner output section configured to output information relating to the air conditioner selected by the air conditioner selection section. a floor area acquisition section configured to acquire a floor area of a target space where the air conditioning unit is to be installed, characterized by: an allowable refrigerant amount acquisition section configured to acquire an allowable refrigerant amount which is amount of a refrigerant allowed to remain in the target space in a case where the refrigerant leaks out of the air conditioning unit into the target space at least based on the floor area acquired by the floor area acquisition section; an air conditioner selection section configured to select the air conditioner that includes the air conditioning unit installable in the target space at least based on the allowable refrigerant amount acquired by the allowable refrigerant amount acquisition section; and an air conditioner output section configured to output information relating to the air conditioner selected by the air conditioner selection section. an allowable refrigerant amount acquisition section configured to acquire an allowable refrigerant amount which is amount of a refrigerant allowed to remain in the target space in a case where the refrigerant leaks out of the air conditioning unit into the target space at least based on the floor area acquired by the floor area acquisition section; an air conditioner selection section configured to select the air conditioner that includes the air conditioning unit installable in the target space at least based on the allowable refrigerant amount acquired by the allowable refrigerant amount acquisition section; and an air conditioner output section configured to output information relating to the air conditioner selected by the air conditioner selection section.
A method for sterilely preparing a lipid-nucleic acid nanoparticle under aseptic conditions, comprising the use of a system comprising single use components, which comprises: a 1 st holding unit for an organic lipid solution comprising lipids in a water-miscible organic solvent; a 2 nd holding unit for an aqueous solution comprising a therapeutic drug; a mixing unit with a static mixer; an injection means to add the organic lipid solution from the 1 st holding unit to the mixing chamber in a way to form a gradient of the organic solvent concentration of the solution in the mixing unit such that the increase is gradual from an injection-initial value to an injection-final value; a 3 rd holding unit for an aqueous buffer; a dilution unit; a concentrating unit comprising a transflow filter for concentrating the liposome suspension and removing the organic solvent; and a single use bed for collecting the concentrated liposome suspension after removal of organic solvent; and wherein all components of the system, which are in contact with lipids, drugs, solvents and buffers are sterilized and disposable so as to be adapted for single batch usage; wherein the method is carried out such that the water-miscible organic solvent is ethanol; the mixing unit contains the aqueous drug solution, and the lipid solution is steadily added to the drug solution in the mixing unit thereby forming said gradient such that the delivery of the organic solution is completed in 1 minute to 100 minutes, such that a RNA:lipid ratio of 0.06 to 0.16 (w:w) is reached and such that a final ethanol concentration of 25-45% is reached; and wherein the lipid-drug mixture is transferred to the dilution unit and is diluted by addition of the aqueous buffer. a 1 st holding unit for an organic lipid solution comprising lipids in a water-miscible organic solvent; a 2 nd holding unit for an aqueous solution comprising a therapeutic drug; a mixing unit with a static mixer; an injection means to add the organic lipid solution from the 1 st holding unit to the mixing chamber in a way to form a gradient of the organic solvent concentration of the solution in the mixing unit such that the increase is gradual from an injection-initial value to an injection-final value; a 3 rd holding unit for an aqueous buffer; a dilution unit; a concentrating unit comprising a transflow filter for concentrating the liposome suspension and removing the organic solvent; and a single use bed for collecting the concentrated liposome suspension after removal of organic solvent; and wherein all components of the system, which are in contact with lipids, drugs, solvents and buffers are sterilized and disposable so as to be adapted for single batch usage;