A compound comprising, preferably consisting of, one or more hydrophobic domains and a hydrophilic domain, wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the one or more hydrophobic domains each comprise a linear lipid, which is a saturated fatty acid having from 12 to 18 C atoms, the steroid cholesterol or the hydrophobic vitamin α-tocopherol, and wherein the hydrophilic domain comprises a compound of Formula: X1-[A1- n] k1 -Z-[A2- n] k2 -X2, wherein Z is linear polyethylene glycol moiety containing 1 to 50, preferably 4-30 -O-CH 2 -CH 2 - moieties, wherein the polyethylene glycol moiety optionally comprises 1 or more spacer moieties SP connecting two -O-CH 2 -CH 2 - moieties, and wherein the linear PEG moiety optionally comprises a linker moiety L3 at one or both ends, each L1 is a linker moiety selected independently from each other, each n is either 0 or 1, selected independently from each other, A1 and A2 are bifunctional or trifunctional moieties selected independently from each other, with the proviso that at least one A1 or A2 is trifunctional, the trifunctional moiety is selected from lysine, serine, serinol, -O-CH2-CH((CH 2) 4 -NH 2)-CH 2 -, a glycerol, and a 1,3 diaminoglycerol moiety, wherein the bifunctional moiety is selected from the group consisting of a phosphate group, carbamate group, amide group, a moiety comprising a nucleobase, even more preferably dT, and a linear alkyl group having 1 to 10 C atoms and which alkyl chain contains functional groups at the terminal C-atoms, in particular independently selected from amine, carbonyl, hydroxyl, thiol, carbonic acid groups, k1 and k2 are selected independently from each other, and k1 is 1, 2, 3, 4, or 5, and k2 is 1, 2, 3, 4, 5 or 6, X1 and X2 are independently selected from hydrogen or a protecting group, L3 is independently selected from a linear alkyl or alkenyl chain with 1 to 10 C atoms, which is optionally (i) interrupted by 1 to 3 N, O or S atoms, and/or (ii) substituted by 1 to 4 hydroxyl, carbonyl, amino or thiol groups, the 1 or more spacer moieties SP are independently from each other and are selected from the group consisting of a phosphate, and a bifunctional moiety, and wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain only via the trifunctional moieties A1, or a salt thereof. Z is linear polyethylene glycol moiety containing 1 to 50, preferably 4-30 -O-CH 2 -CH 2 - moieties, wherein the polyethylene glycol moiety optionally comprises 1 or more spacer moieties SP connecting two -O-CH 2 -CH 2 - moieties, and wherein the linear PEG moiety optionally comprises a linker moiety L3 at one or both ends, each L1 is a linker moiety selected independently from each other, each n is either 0 or 1, selected independently from each other, A1 and A2 are bifunctional or trifunctional moieties selected independently from each other, with the proviso that at least one A1 or A2 is trifunctional, the trifunctional moiety is selected from lysine, serine, serinol, -O-CH2-CH((CH 2) 4 -NH 2)-CH 2 -, a glycerol, and a 1,3 diaminoglycerol moiety, wherein the bifunctional moiety is selected from the group consisting of a phosphate group, carbamate group, amide group, a moiety comprising a nucleobase, even more preferably dT, and a linear alkyl group having 1 to 10 C atoms and which alkyl chain contains functional groups at the terminal C-atoms, in particular independently selected from amine, carbonyl, hydroxyl, thiol, carbonic acid groups, k1 and k2 are selected independently from each other, and k1 is 1, 2, 3, 4, or 5, and k2 is 1, 2, 3, 4, 5 or 6, X1 and X2 are independently selected from hydrogen or a protecting group, L3 is independently selected from a linear alkyl or alkenyl chain with 1 to 10 C atoms, which is optionally (i) interrupted by 1 to 3 N, O or S atoms, and/or (ii) substituted by 1 to 4 hydroxyl, carbonyl, amino or thiol groups, the 1 or more spacer moieties SP are independently from each other and are selected from the group consisting of a phosphate, and a bifunctional moiety, and wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain only via the trifunctional moieties A1,