A surgical instrument, comprising: an end effector (26000, 26050), comprising: a first jaw; a second jaw movable relative to the first jaw to grasp tissue therebetween; an anvil; a staple cartridge comprising staples deployable into the tissue, wherein the staples are deformable by the anvil; and a sensor assembly comprising: a first sensor on a first side of a longitudinal axis extending through the staple cartridge; and a second sensor on a second side of the longitudinal axis; wherein the sensor assembly is configured to provide sensor signals according to a physiological parameter of the tissue, wherein the physiological parameter is indicative of the proximity of the sensors to cancerous tissue; a control circuit coupled to the sensor assembly, wherein the control circuit is configured to: receive a first sensor signal from the first sensor; receive a second sensor signal from the second sensor; determine a first value of the physiological parameter based on the first sensor signal; determine a second value of the physiological parameter based on the second sensor signal; and compare the first value and the second value to the predetermined threshold, characterized in that the control circuit is further configured to provide instructions to move the end effector in a first direction in the event the first value but not the second value reaches or crosses the predetermined threshold, and wherein the first direction extends away from the longitudinal axis on the first side or characterized in that the control circuit is further configured to provide instructions to move the end effector in a second direction in the event the second value but not the first value reaches or crosses the predetermined threshold, and wherein the second direction extends away from the longitudinal axis on the second side. a first jaw; a second jaw movable relative to the first jaw to grasp tissue therebetween; an anvil; a staple cartridge comprising staples deployable into the tissue, wherein the staples are deformable by the anvil; and a sensor assembly comprising: a first sensor on a first side of a longitudinal axis extending through the staple cartridge; and a second sensor on a second side of the longitudinal axis; wherein the sensor assembly is configured to provide sensor signals according to a physiological parameter of the tissue, wherein the physiological parameter is indicative of the proximity of the sensors to cancerous tissue; a control circuit coupled to the sensor assembly, wherein the control circuit is configured to: receive a first sensor signal from the first sensor; receive a second sensor signal from the second sensor; determine a first value of the physiological parameter based on the first sensor signal; determine a second value of the physiological parameter based on the second sensor signal; and compare the first value and the second value to the predetermined threshold, a first sensor on a first side of a longitudinal axis extending through the staple cartridge; and a second sensor on a second side of the longitudinal axis; wherein the sensor assembly is configured to provide sensor signals according to a physiological parameter of the tissue, wherein the physiological parameter is indicative of the proximity of the sensors to cancerous tissue; a control circuit coupled to the sensor assembly, wherein the control circuit is configured to: receive a first sensor signal from the first sensor; receive a second sensor signal from the second sensor; determine a first value of the physiological parameter based on the first sensor signal; determine a second value of the physiological parameter based on the second sensor signal; and compare the first value and the second value to the predetermined threshold, characterized in that the control circuit is further configured to provide instructions to move the end effector in a first direction in the event the first value but not the second value reaches or crosses the predetermined threshold, and wherein the first direction extends away from the longitudinal axis on the first side or characterized in that the control circuit is further configured to provide instructions to move the end effector in a second direction in the event the second value but not the first value reaches or crosses the predetermined threshold, and wherein the second direction extends away from the longitudinal axis on the second side.