An in-flight risk management system comprising: an eye sensor installed in a cockpit of an aircraft; a leg movement sensor installed in the cockpit of the aircraft, wherein the leg movement sensor is configured to detect changes in pressure provided by legs of a flight crew member on a seat; one or more in-flight risk management, IRM, computers in communication with the eye sensors and the leg movement sensor; and one or more data stores in communication with the one or more IRM computers and storing instructions that, when executed, cause the one or more IRM computers to perform operations comprising: obtaining history information for the flight crew member, the history information comprising data that is representative of rest and wake activity of the flight crew member over a period of time; obtaining flight information associated with a flight on which the flight crew member will be present, the flight information indicating a series of events during the flight; determining, based on the history information and the flight information, a predicted fatigue profile for the flight crew member; determining, based on the predicted fatigue profile for the flight crew member, one or more fatigue indicator profiles for the flight crew member, the one or more fatigue indicator profiles representing values of one or more respective measureable fatigue indicators; obtaining, from the eye sensor and the leg movement sensor, one or more measured fatigue indicator values associated with the flight crew member; generating, based on the one or more measured fatigue indicator values, one or more updated fatigue indicator profiles; and generating, based on the one or more updated fatigue indicator profiles, an updated predicted fatigue profile. an eye sensor installed in a cockpit of an aircraft; a leg movement sensor installed in the cockpit of the aircraft, wherein the leg movement sensor is configured to detect changes in pressure provided by legs of a flight crew member on a seat; one or more in-flight risk management, IRM, computers in communication with the eye sensors and the leg movement sensor; and one or more data stores in communication with the one or more IRM computers and storing instructions that, when executed, cause the one or more IRM computers to perform operations comprising: obtaining history information for the flight crew member, the history information comprising data that is representative of rest and wake activity of the flight crew member over a period of time; obtaining flight information associated with a flight on which the flight crew member will be present, the flight information indicating a series of events during the flight; determining, based on the history information and the flight information, a predicted fatigue profile for the flight crew member; determining, based on the predicted fatigue profile for the flight crew member, one or more fatigue indicator profiles for the flight crew member, the one or more fatigue indicator profiles representing values of one or more respective measureable fatigue indicators; obtaining, from the eye sensor and the leg movement sensor, one or more measured fatigue indicator values associated with the flight crew member; generating, based on the one or more measured fatigue indicator values, one or more updated fatigue indicator profiles; and generating, based on the one or more updated fatigue indicator profiles, an updated predicted fatigue profile. obtaining history information for the flight crew member, the history information comprising data that is representative of rest and wake activity of the flight crew member over a period of time; obtaining flight information associated with a flight on which the flight crew member will be present, the flight information indicating a series of events during the flight; determining, based on the history information and the flight information, a predicted fatigue profile for the flight crew member; determining, based on the predicted fatigue profile for the flight crew member, one or more fatigue indicator profiles for the flight crew member, the one or more fatigue indicator profiles representing values of one or more respective measureable fatigue indicators; obtaining, from the eye sensor and the leg movement sensor, one or more measured fatigue indicator values associated with the flight crew member; generating, based on the one or more measured fatigue indicator values, one or more updated fatigue indicator profiles; and generating, based on the one or more updated fatigue indicator profiles, an updated predicted fatigue profile.