A compound selected from Formula I: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 is selected from: where the wavy line indicates the site of attachment; R 4 is selected from OH, CN, NR b R c, C 3 -C 6 cycloalkyl optionally substitituted with C 1 -C 6 alkyl or C 1 -C 4 haloalkyl, and C 1 -C 6 alkyl optionally substituted with OH or OC 1 -C 4 alkyl; R 2 is H, CH 3 or CF 3; ring B is selected from phenyl, 5-6 membered heteroaryl having at least one nitrogen ring atom, and 8-11 membered heterocyclyl having at least one nitrogen ring atom; R 3 is independently selected from H, -R a, -OR b, -SR b, -NR b R c, halo, cyano, nitro, -COR b, -CO 2 R b, -CONR b R c, -OCOR b, -OCO 2 R a, -OCONR b R c, -NR c COR b, -NR c CO 2 R a, -NR c CONR b R c, -CO 2 R b, -CONR b R c, -NR c COR b, -SOR a, -SO 2 R a, -SO 2 NR b R c, and -NR c SO 2 R a; or two adjacent R 3 groups are optionally taken together to form a 5-6 membered ring having 0-2 heteroatoms selected from O, S or N, wherein said 5-6 membered ring is fused to ring B; R a is C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein each member of R a is optionally substituted with one to three R 11 groups; R b is H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein each member of R b except H is optionally substituted with one to three R 11 groups; R c is H or C 1 -C 4 alkyl optionally substituted with one or three R 11 groups; or R b and R c, and the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl group; each R 11 is independently selected from C 1 -C 4 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, cycloalkyl-C 1 -C 4 alkyl-, heterocycloalkyl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl-, -OC 1 -C 4 alkyl, -O-heterocycloalkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -CO 2 H, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 phenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); R 6 is H, CH 3, F, Cl, CN, OCH 3, OH, or methyl substituted with OH, OCH 3 or one or more halo groups; R 7 is H, CH 3, F, Cl, CN or OCH 3; R 8 is H, CH 3, CF 3, F, Cl, CN or OCH 3; each R 9 is independently C 1 -C 3 alkyl; and each R 10 is independently H or CH 3. R 1 is selected from: where the wavy line indicates the site of attachment; R 4 is selected from OH, CN, NR b R c, C 3 -C 6 cycloalkyl optionally substitituted with C 1 -C 6 alkyl or C 1 -C 4 haloalkyl, and C 1 -C 6 alkyl optionally substituted with OH or OC 1 -C 4 alkyl; R 2 is H, CH 3 or CF 3; ring B is selected from phenyl, 5-6 membered heteroaryl having at least one nitrogen ring atom, and 8-11 membered heterocyclyl having at least one nitrogen ring atom; R 3 is independently selected from H, -R a, -OR b, -SR b, -NR b R c, halo, cyano, nitro, -COR b, -CO 2 R b, -CONR b R c, -OCOR b, -OCO 2 R a, -OCONR b R c, -NR c COR b, -NR c CO 2 R a, -NR c CONR b R c, -CO 2 R b, -CONR b R c, -NR c COR b, -SOR a, -SO 2 R a, -SO 2 NR b R c, and -NR c SO 2 R a; or two adjacent R 3 groups are optionally taken together to form a 5-6 membered ring having 0-2 heteroatoms selected from O, S or N, wherein said 5-6 membered ring is fused to ring B; R a is C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein each member of R a is optionally substituted with one to three R 11 groups; R b is H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein each member of R b except H is optionally substituted with one to three R 11 groups; R c is H or C 1 -C 4 alkyl optionally substituted with one or three R 11 groups; or R b and R c, and the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl group; each R 11 is independently selected from C 1 -C 4 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, cycloalkyl-C 1 -C 4 alkyl-, heterocycloalkyl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl-, -OC 1 -C 4 alkyl, -O-heterocycloalkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -CO 2 H, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 phenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); R 6 is H, CH 3, F, Cl, CN, OCH 3, OH, or methyl substituted with OH, OCH 3 or one or more halo groups; R 7 is H, CH 3, F, Cl, CN or OCH 3; R 8 is H, CH 3, CF 3, F, Cl, CN or OCH 3; each R 9 is independently C 1 -C 3 alkyl; and each R 10 is independently H or CH 3.