An integrated sealed micro-mesh nebulization module, comprising: a nebulization device and a nozzle mechanism disposed on the nebulization device, wherein the nozzle mechanism disposed on the nebulization device is detachably connected with the nebulization device; wherein the nebulization device comprises an annular base, a lower shell disposed in the annular base, an upper shell disposed on the lower shell, a micro-mesh nebulization sheet disposed on the lower shell, a first sealing ring and a second sealing ring respectively disposed on both sides of the micro-mesh nebulization sheet, and a metal contact disposed between the lower shell and the upper shell, with one end connected with the micro-mesh nebulization sheet through a wire, and the other end extending to an exterior of the lower shell and connected with an external driving circuit; wherein a first through hole is disposed in a center of the upper shell, and a second through hole corresponding to the first through hole is disposed in a center of the lower shell; wherein the nozzle mechanism comprises a bottom cover disposed on one side of the upper shell in the annular base, a tubular spout disposed on the bottom cover, and gas outlets for discharging excess atomized gas respectively disposed on the bottom cover at upper and lower sides of the spout; and wherein the bottom cover is provided with a central hole corresponding to the first through hole; and characterized in that a first gas channel is further provided at an inner wall of the spout, the nebulization device is further provided with a second gas channel corresponding to the first gas channel, and the first gas channel is communicated with the second gas channel. a nebulization device and a nozzle mechanism disposed on the nebulization device, wherein the nozzle mechanism disposed on the nebulization device is detachably connected with the nebulization device; wherein the nebulization device comprises an annular base, a lower shell disposed in the annular base, an upper shell disposed on the lower shell, a micro-mesh nebulization sheet disposed on the lower shell, a first sealing ring and a second sealing ring respectively disposed on both sides of the micro-mesh nebulization sheet, and a metal contact disposed between the lower shell and the upper shell, with one end connected with the micro-mesh nebulization sheet through a wire, and the other end extending to an exterior of the lower shell and connected with an external driving circuit; wherein a first through hole is disposed in a center of the upper shell, and a second through hole corresponding to the first through hole is disposed in a center of the lower shell; wherein the nozzle mechanism comprises a bottom cover disposed on one side of the upper shell in the annular base, a tubular spout disposed on the bottom cover, and gas outlets for discharging excess atomized gas respectively disposed on the bottom cover at upper and lower sides of the spout; and wherein the bottom cover is provided with a central hole corresponding to the first through hole; and characterized in that a first gas channel is further provided at an inner wall of the spout, the nebulization device is further provided with a second gas channel corresponding to the first gas channel, and the first gas channel is communicated with the second gas channel.