A method of scaling amperometric data obtained during an electrochemical analysis of an analyte of interest to compensate for hematocrit and temperature, the method comprising the steps of: applying to a body fluid sample a test sequence comprising at least one AC block of low-amplitude signals in connection with at least one DC block, wherein the AC block comprises a multi-frequency excitation waveform of at least two different frequencies, wherein the body fluid sample comprises the analyte of interest; measuring AC and DC current responses to an electro-active species indicative of the analyte of interest; determining a solution resistance (R solution) from the AC current response information, wherein the R solution is estimated from a linear fit of an x-intercept obtained by plotting impedance of the current responses to the block of low-amplitude AC signals in a Nyquist plot, wherein the x-intercept is the estimate of the R solution; and scaling the amperometric data by multiplying the DC current responses by R solution to obtain a compensated voltage drop that minimizes an influence of hematocrit on an estimated analyte concentration, wherein the method further comprises the step of estimating the analyte concentration based upon combining the compensated voltage drop with one or more descriptors of the scaled amperometric data for describing the temperature influence, wherein the descriptors are calculated by subtracting R solution from the actual real impedance, then calculating new impedance magnitudes for each frequency, converting the new impedance magnitudes to admittance magnitudes, and calculating real and imaginary admittance values and corresponding new angles. applying to a body fluid sample a test sequence comprising at least one AC block of low-amplitude signals in connection with at least one DC block, wherein the AC block comprises a multi-frequency excitation waveform of at least two different frequencies, wherein the body fluid sample comprises the analyte of interest; measuring AC and DC current responses to an electro-active species indicative of the analyte of interest; determining a solution resistance (R solution) from the AC current response information, wherein the R solution is estimated from a linear fit of an x-intercept obtained by plotting impedance of the current responses to the block of low-amplitude AC signals in a Nyquist plot, wherein the x-intercept is the estimate of the R solution; and scaling the amperometric data by multiplying the DC current responses by R solution to obtain a compensated voltage drop that minimizes an influence of hematocrit on an estimated analyte concentration, wherein the method further comprises the step of estimating the analyte concentration based upon combining the compensated voltage drop with one or more descriptors of the scaled amperometric data for describing the temperature influence, wherein the descriptors are calculated by subtracting R solution from the actual real impedance, then calculating new impedance magnitudes for each frequency, converting the new impedance magnitudes to admittance magnitudes, and calculating real and imaginary admittance values and corresponding new angles.