An in vitro method of determining whether a subject is suffering from, or at risk of suffering from, high risk adenomas or colorectal cancer, the method comprising the steps of: (a) providing a biological sample previously obtained from a subject; (b) determining the levels of carcinoembryonic antigen, Cytokeratin 19 Fragment (CYFRA), C-reactive protein, and ferritin in the biological sample from the subject; (c) comparing the levels of CEA, CYFRA, CRP, and ferritin in the biological sample to reference levels of CEA, CYFRA, CRP, and ferritin; (i) providing a CEA score for the subject wherein the subject gets a score of 1 if the level of CEA in the biological sample is greater than the reference level of CEA and a score of 0 if the level of CEA in the biological sample is equal or less than the reference level of CEA; (ii) providing a CYFRA score for the subject wherein the subject gets a score of 1 if the level of CYFRA in the biological sample is greater than the reference level of CYFRA and a score of 0 if the level of CYFRA in the biological sample is equal or less than the reference level of CYFRA; (iii) providing a CRP score for the subject wherein the subject gets a score of 1 if the level of CRP in the biological sample is greater than the reference level of CRP and a score of 0 if the level of CRP in the biological sample is equal or less than the reference level of CRP; and (iv) providing a ferritin score for the subject wherein the subject gets a score of 1 if the level of ferritin in the biological sample is less than the reference level of ferritin and a score of 0 if the level of ferritin in the biological sample is equal or greater than the reference level of ferritin; (d) adding the scores from step (c) to generate a total score; and (e) providing a diagnosis of a subject as suffering from, or at risk of suffering from, high risk adenomas or CRC if the total score is greater than a reference score, or a diagnosis of a subject as not suffering from, or not at risk of suffering from, high risk adenomas or CRC if the total score is equal to or less than the reference score. (a) providing a biological sample previously obtained from a subject; (b) determining the levels of carcinoembryonic antigen, Cytokeratin 19 Fragment (CYFRA), C-reactive protein, and ferritin in the biological sample from the subject; (c) comparing the levels of CEA, CYFRA, CRP, and ferritin in the biological sample to reference levels of CEA, CYFRA, CRP, and ferritin; (i) providing a CEA score for the subject wherein the subject gets a score of 1 if the level of CEA in the biological sample is greater than the reference level of CEA and a score of 0 if the level of CEA in the biological sample is equal or less than the reference level of CEA; (ii) providing a CYFRA score for the subject wherein the subject gets a score of 1 if the level of CYFRA in the biological sample is greater than the reference level of CYFRA and a score of 0 if the level of CYFRA in the biological sample is equal or less than the reference level of CYFRA; (iii) providing a CRP score for the subject wherein the subject gets a score of 1 if the level of CRP in the biological sample is greater than the reference level of CRP and a score of 0 if the level of CRP in the biological sample is equal or less than the reference level of CRP; and (iv) providing a ferritin score for the subject wherein the subject gets a score of 1 if the level of ferritin in the biological sample is less than the reference level of ferritin and a score of 0 if the level of ferritin in the biological sample is equal or greater than the reference level of ferritin; (i) providing a CEA score for the subject wherein the subject gets a score of 1 if the level of CEA in the biological sample is greater than the reference level of CEA and a score of 0 if the level of CEA in the biological sample is equal or less than the reference level of CEA; (ii) providing a CYFRA score for the subject wherein the subject gets a score of 1 if the level of CYFRA in the biological sample is greater than the reference level of CYFRA and a score of 0 if the level of CYFRA in the biological sample is equal or less than the reference level of CYFRA; (iii) providing a CRP score for the subject wherein the subject gets a score of 1 if the level of CRP in the biological sample is greater than the reference level of CRP and a score of 0 if the level of CRP in the biological sample is equal or less than the reference level of CRP; and (iv) providing a ferritin score for the subject wherein the subject gets a score of 1 if the level of ferritin in the biological sample is less than the reference level of ferritin and a score of 0 if the level of ferritin in the biological sample is equal or greater than the reference level of ferritin; (d) adding the scores from step (c) to generate a total score; and (e) providing a diagnosis of a subject as suffering from, or at risk of suffering from, high risk adenomas or CRC if the total score is greater than a reference score, or a diagnosis of a subject as not suffering from, or not at risk of suffering from, high risk adenomas or CRC if the total score is equal to or less than the reference score.