A stone extraction and fragmentation device comprising: a cylindrical insertion section which is configured to be inserted into a channel of an endoscope; a treatment section which is located at a distal end of the insertion section; an operation wire which is inserted in the insertion section and configured to be advanced or retreated and to drive the treatment section; a first operation section which is provided at a proximal end of the insertion section; and a second operation section which is configured to be attached to or detached from the first operation section, wherein the first operation section includes: a first main body which is connected to the proximal end of the insertion section; and a gripping section to which the operation wire is connected and which is configured to be advanced or retreated with respect to the first main body; wherein the second operation section includes: a second main body which is configured to be connected to the gripping section; a moving body which is disposed inside the second main body and configured to be connected to the first main body; and a rotating knob which is disposed at the second main body and configured to cause the moving body to be advanced or retreated with respect to the second main body, wherein when the moving body is connected to the first main body and the gripping section is connected to the second main body, the gripping section moves in a direction away from the first main body by moving the moving body in a direction away from the second operation section by rotation of the rotating knob, so that the treatment section is driven. a cylindrical insertion section which is configured to be inserted into a channel of an endoscope; a treatment section which is located at a distal end of the insertion section; an operation wire which is inserted in the insertion section and configured to be advanced or retreated and to drive the treatment section; a first operation section which is provided at a proximal end of the insertion section; and a second operation section which is configured to be attached to or detached from the first operation section, wherein the first operation section includes: a first main body which is connected to the proximal end of the insertion section; and a gripping section to which the operation wire is connected and which is configured to be advanced or retreated with respect to the first main body; a first main body which is connected to the proximal end of the insertion section; and a gripping section to which the operation wire is connected and which is configured to be advanced or retreated with respect to the first main body; wherein the second operation section includes: a second main body which is configured to be connected to the gripping section; a moving body which is disposed inside the second main body and configured to be connected to the first main body; and a rotating knob which is disposed at the second main body and configured to cause the moving body to be advanced or retreated with respect to the second main body, wherein when the moving body is connected to the first main body and the gripping section is connected to the second main body, the gripping section moves in a direction away from the first main body by moving the moving body in a direction away from the second operation section by rotation of the rotating knob, so that the treatment section is driven. a second main body which is configured to be connected to the gripping section; a moving body which is disposed inside the second main body and configured to be connected to the first main body; and a rotating knob which is disposed at the second main body and configured to cause the moving body to be advanced or retreated with respect to the second main body, wherein when the moving body is connected to the first main body and the gripping section is connected to the second main body, the gripping section moves in a direction away from the first main body by moving the moving body in a direction away from the second operation section by rotation of the rotating knob, so that the treatment section is driven.