A compound of Formula: wherein: Z 1 is pyridine or pyrazole, wherein the pyridine or pyrazole is optionally substituted with halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or a 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', - NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, Cl-C6 alkyl, aryl, or C3-C7 cycloalkyl; Z 2 is phenyl, naphthyl, or C5-C10 membered heterocycle, wherein the phenyl, naphthyl, or C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', - SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or a 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, - COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, or C3-C7 cycloalkyl; R is -C1-C6 alkyl, optionally substituted with one or more -OH; R 1 is H, C1-C6 alkyl, or C3-C7 cycloalkyl, wherein the C1-C6 alkyl, or C3-C7-cycloalkyl is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", or -S 2 R'; X is a bond or -O(C1-C6 alkyl); and R 2 and R 3 are independently H, C1-C6 alkyl or C3-C7 cycloalkyl, aryl, or C5-C10 membered heterocycle, wherein the C1-C6 alkyl, C3-C7 cycloalkyl, aryl, or C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', - SR', -OC R', -NHR', -NR'R", -CNR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, - OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, or C3-C7 cycloalkyl; wherein R 5 is C1-C6 alkyl, -OCH 2 CH 2 -, -NR 6 CH 2 CH 2 -, or -NC CH 2 CH 2 -; and R 6 is H, C1-C6 alkyl or C3-C7 cycloalkyl; and wherein R' and R" are independently H or C1-C6 alkyl; and wherein R' and R" together, optionally attaching to N or O atom, may form a 4- to 8-membered cyclic structure. Z 1 is pyridine or pyrazole, wherein the pyridine or pyrazole is optionally substituted with halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or a 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', - NHC NR'R", -C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, Cl-C6 alkyl, aryl, or C3-C7 cycloalkyl; Z 2 is phenyl, naphthyl, or C5-C10 membered heterocycle, wherein the phenyl, naphthyl, or C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', - SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or a 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, -OH, -CN, - COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, or C3-C7 cycloalkyl; R is -C1-C6 alkyl, optionally substituted with one or more -OH; R 1 is H, C1-C6 alkyl, or C3-C7 cycloalkyl, wherein the C1-C6 alkyl, or C3-C7-cycloalkyl is optionally substituted with one or more of the following: halo, -OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", -C NR'R", -NS 2 R', - S 2 NR'R", or -S 2 R'; X is a bond or -O(C1-C6 alkyl); and R 2 and R 3 are independently H, C1-C6 alkyl or C3-C7 cycloalkyl, aryl, or C5-C10 membered heterocycle, wherein the C1-C6 alkyl, C3-C7 cycloalkyl, aryl, or C5-C10 membered heterocycle is optionally substituted with halo, -OH, -CN, -COOR', -OR', - SR', -OC R', -NHR', -NR'R", -CNR'R", -NHC R', -NHC NR'R", -C NR'R", - NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle, wherein the C1-C6 alkyl, aryl, C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is unsubstituted or substituted with one or more of the following: halo, - OH, -CN, -COOR', -OR', -SR', -OC R', -NHR', -NR'R", -NHC R', -NHC NR'R", - C NR'R", -NS 2 R', -S 2 NR'R", -S 2 R', guanidino, nitro, nitroso, C1-C6 alkyl, aryl, or C3-C7 cycloalkyl; wherein R 5 is C1-C6 alkyl, -OCH 2 CH 2 -, -NR 6 CH 2 CH 2 -, or -NC CH 2 CH 2 -; and R 6 is H, C1-C6 alkyl or C3-C7 cycloalkyl; and wherein R' and R" are independently H or C1-C6 alkyl; and wherein R' and R" together, optionally attaching to N or O atom, may form a 4- to 8-membered cyclic structure.