mhurhangee/ep-ind-claims huggingface dataset:
A method of determining a suitable dosage for an individual in need of treatment with a statin, comprising i) determining whether the genotype of the individual is heterozygous or homozygous for one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual; and ii) determining a suitable dosage for statin treatment by reference to the genotype of the one or more polymorphisms, whereby a standard dose of a statin is suitable for an individual with a heterozygous or homozygous high-risk genotype and a higher dose is suitable for an individual with a homozygous low-risk genotype, wherein the high-risk genotype of the one or more polymorphisms is associated with increased risk of statin-induced myopathy and wherein the low-risk genotype of the one or more polymorphisms is associated with decreased risk of statin-induced myopathy, wherein the one or more polymorphisms are selected from the group consisting of SNPs rs4149056, rs4363657, rs1871395, rs12317268, rs2900478, rs4149100, rs4149081, rs11045879, rs7969341, rs11045885, rs12369881 and rs12366582; and wherein, a high-risk genotype at rs4149056 is defined as a CC or TC genotype, and a low-risk genotype at rs4149056 is defined as a TT genotype; a high-risk genotype at rsl871395, rs12317268, rs7969341, rs1045885 or rs12366582 is defined as a GG or GA genotype and a low-risk genotype at rsl871395, rs12317268, rs7969341, rs1045885 or rs12366582 is defined as a AA genotype; a high-risk genotype at rs4149081 or rs12369881 is defined as a AA or AG genotype, and a low-risk genotype at rs4149081 or rs12369881 is defined as a GG genotype; a high-risk genotype at rs4363657 or rs11045879 is defined as a CC or CT genotype, and a low-risk genotype at rs4363657 or rs11045879 is defined as a TT genotype; a high-risk genotype at rs2900478 is defined as a AA or AT genotype, and a low-risk genotype at rs2900478 is defined as a TT genotype; and a high-risk genotype at rs4149100 is defined as a genotype that is homozygous for a deletion or heterozygous for a deletion, and a low-risk genotype rs4149100 is defined as a AA genotype. i) determining whether the genotype of the individual is heterozygous or homozygous for one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual; and ii) determining a suitable dosage for statin treatment by reference to the genotype of the one or more polymorphisms, whereby a standard dose of a statin is suitable for an individual with a heterozygous or homozygous high-risk genotype and a higher dose is suitable for an individual with a homozygous low-risk genotype, wherein the high-risk genotype of the one or more polymorphisms is associated with increased risk of statin-induced myopathy and wherein the low-risk genotype of the one or more polymorphisms is associated with decreased risk of statin-induced myopathy,
Fire barrier for a building, especially a fire door, comprising - a frame consisting of two parallel elements and two elements being shorter in length than the elements and being arranged perpendicular to the elements and parallel to each other and defining a hollow space, - at least one insulation element of rectangular shape having two main surfaces being arranged parallel to each other and being connected via side faces, and - covering elements being arranged parallel to the main surfaces of the insulation element, - which covering elements are connected to the frame, - which insulation element is inserted into the hollow space, - which insulation element is divided into at least two parts (10, 11) along an abutment namely a first part and a second part, characterised in that the abutment extends nonparallel to the side faces, especially from two corner regions (13, 14) being the connection area of two side faces which corner regions (13,14) are arranged diametrically opposed to each other. - a frame consisting of two parallel elements and two elements being shorter in length than the elements and being arranged perpendicular to the elements and parallel to each other and defining a hollow space, - at least one insulation element of rectangular shape having two main surfaces being arranged parallel to each other and being connected via side faces, and - covering elements being arranged parallel to the main surfaces of the insulation element, - which covering elements are connected to the frame, - which insulation element is inserted into the hollow space, - which insulation element is divided into at least two parts (10, 11) along an abutment namely a first part and a second part, characterised in that the abutment extends nonparallel to the side faces, especially from two corner regions (13, 14) being the connection area of two side faces which corner regions (13,14) are arranged diametrically opposed to each other.
A method for obtaining an improved fortifier from wastewater yeast with low protein concentration comprising: obtaining a sample of waste water from a brewer's water; filtering the wastewater through a 80 μm pore filter; magnetically treating a liquid portion of the filtering step; adding at least 6 times a volume of a mixing of a shredded and homogenized fish waste with a saline solution, 0,9% NaCl in weight, in a proportion of 1 kg / 6-10 liters, and adjusting the pH to 5 with acetic acid to form a slurry; adding to the slurry amino acids and magnesium salt maintaining a content greater than 0.1% dry weight of free amino acids during incubation and at least 0.1% dry weight content of magnesium cation (Mg +2); keeping in the slurry concentrations of nitrogen, phosphate, and potassium to less than 3% as a whole; fermenting the slurry at temperatures of between 24°C and 26°C, making a smooth, continuous motion of the slurry to form a fermenting product; incubating the fermenting product for 20 to 40 days, depending on the desired degree of concentration of the final components; filtering the incubating product through 80 μm pore filter; and adjusting the pH between 4.5 and 7.0. obtaining a sample of waste water from a brewer's water; filtering the wastewater through a 80 μm pore filter; magnetically treating a liquid portion of the filtering step; adding at least 6 times a volume of a mixing of a shredded and homogenized fish waste with a saline solution, 0,9% NaCl in weight, in a proportion of 1 kg / 6-10 liters, and adjusting the pH to 5 with acetic acid to form a slurry; adding to the slurry amino acids and magnesium salt maintaining a content greater than 0.1% dry weight of free amino acids during incubation and at least 0.1% dry weight content of magnesium cation (Mg +2); keeping in the slurry concentrations of nitrogen, phosphate, and potassium to less than 3% as a whole; fermenting the slurry at temperatures of between 24°C and 26°C, making a smooth, continuous motion of the slurry to form a fermenting product; incubating the fermenting product for 20 to 40 days, depending on the desired degree of concentration of the final components; filtering the incubating product through 80 μm pore filter; and adjusting the pH between 4.5 and 7.0.
A method for producing a fracture-divided component, especially a connecting rod, with an at least partially coated bore, comprising the following steps: - providing an unfinished component; - applying a coating of a bearing material to a bore surface; and - forming the coating to compensate inner tensile stresses in the coating; characterised in that the forming of the coating takes place before a fraction division of the component. - providing an unfinished component; - applying a coating of a bearing material to a bore surface; and - forming the coating to compensate inner tensile stresses in the coating;
A candle light assembly comprising: a bulb enclosing a volume and having an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a heat sink base with an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a connector for securing the bulb to the heat sink base, which has an upper exterior threaded portion for communicating with the threaded bulb and a lower exterior threaded portion for communicating with the threaded base; and an optics assembly comprising an LED, a lens, and a drive circuit for operating the LED. a bulb enclosing a volume and having an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a heat sink base with an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a connector for securing the bulb to the heat sink base, which has an upper exterior threaded portion for communicating with the threaded bulb and a lower exterior threaded portion for communicating with the threaded base; and an optics assembly comprising an LED, a lens, and a drive circuit for operating the LED.
Method for operating a driver assistance system (5, 5') of at least one motor vehicle (2, 2') in a towing combination comprising a first towing motor vehicle and a second towed motor vehicle, comprising the steps: - activation of a towing mode, which differs from a normal operating mode, of at least one sensor device (6, 6') of the driver assistance system (5, 5'); - detection by the at least one sensor device (6, 6') set to a towing mode of the other motor vehicle (2', 2') arranged behind or in front of the motor vehicle (2, 2') in question in the towing combination; - provision of position information concerning the detected other motor vehicle (2', 2) to a further device (7, 7') of the driver assistance system (5, 5') by the sensor device (6, 6'), characterised in that - the sensor device (6, 6') has a radar sensor device, which is operated in the towing mode with an increased frequency bandwidth compared with the normal operating mode. - activation of a towing mode, which differs from a normal operating mode, of at least one sensor device (6, 6') of the driver assistance system (5, 5'); - detection by the at least one sensor device (6, 6') set to a towing mode of the other motor vehicle (2', 2') arranged behind or in front of the motor vehicle (2, 2') in question in the towing combination; - provision of position information concerning the detected other motor vehicle (2', 2) to a further device (7, 7') of the driver assistance system (5, 5') by the sensor device (6, 6'), characterised in that - the sensor device (6, 6') has a radar sensor device, which is operated in the towing mode with an increased frequency bandwidth compared with the normal operating mode.
A method for operating a mobile radio station, wherein the communication between base station and mobile radio station is conducted via a relay radio station, wherein the mobile radio station is operated in an energy-saving mode, in which it is temporarily placed in a sleep state, wherein the relay radio station is also operated in an energy saving mode, in which it is temporarily placed in a sleep state, wherein the sleep-/wake states of the mobile radio station and the relay radio station are synchronized, wherein a first, second or third control message is sent to the mobile radio station from the relay radio station, wherein in the first control message it is communicated to the mobile radio station, how the sleep-/wake cycle of the relay radio station is in relation to the downlink-transmission direction from the point of view of the mobile radio station, wherein in the second control message it is communicated to the mobile radio station, how the sleep-/wake cycle of the relay radio station is in relation to the uplink-transmission direction from the point of view of the mobile radio station and wherein in the third control message (DS_Config) it is communicated to the mobile radio station, how the sleep-/wake cycle of the relay radio station is in relation to the transmission of synchronization information to the mobile radio station, wherein the mobile radio station sends back a confirmation message to the relay radio station, in which the receipt and acceptance of the sleep-/wake cycle communicated in the first, second or third control message is confirmed, characterized in that instead of the confirmation message a negative confirmation message is sent back to the relay radio station, with which the non-acceptance of the sleep-/wake cycle communicated in the first, second or third control message is communicated to the relay radio station, wherein a counter-proposal for agreement on a modified sleep-/wake cycle is contained in the negative confirmation message, and wherein the relay radio station is operated in a motor vehicle.
A laser light source apparatus, comprising: a base whose upper surface is a flat surface; a plurality of laser light source elements (101 to 104) arranged on the upper surface of the base and also on lattice points which are intersection points between an x axis group and a y axis group, in which an x axis directed to a direction parallel to the upper surface of the base and a y axis directed to a direction parallel to the upper surface of the base and to a direction intersecting with the x axis are arranged, respectively; a plurality of lenses (41 to 44) configured to parallelize laser light being output from the plurality of laser light source elements (101 to 104); a spacer disposed on the upper surface of the base to support the plurality of lenses (41 to 44); and an adhesive agent fixing the plurality of lenses (41 to 44) to the spacer, wherein the spacer includes, for each of the lenses (41 to 44), an annular support surface supporting a lower surface of each of the lenses (41 to 44) and a wall to which a side surface of each of the lenses (41 to 44) is fixed by the adhesive agent, and the wall has a clearance groove formed along a direction connecting diagonal points of the lattice points. a base whose upper surface is a flat surface; a plurality of laser light source elements (101 to 104) arranged on the upper surface of the base and also on lattice points which are intersection points between an x axis group and a y axis group, in which an x axis directed to a direction parallel to the upper surface of the base and a y axis directed to a direction parallel to the upper surface of the base and to a direction intersecting with the x axis are arranged, respectively; a plurality of lenses (41 to 44) configured to parallelize laser light being output from the plurality of laser light source elements (101 to 104); a spacer disposed on the upper surface of the base to support the plurality of lenses (41 to 44); and an adhesive agent fixing the plurality of lenses (41 to 44) to the spacer, wherein the spacer includes, for each of the lenses (41 to 44), an annular support surface supporting a lower surface of each of the lenses (41 to 44) and a wall to which a side surface of each of the lenses (41 to 44) is fixed by the adhesive agent, and the wall has a clearance groove formed along a direction connecting diagonal points of the lattice points.
An interface for a frozen dessert machine comprising: a) a freezer door (310, 410) having opposed front and rear sides and including at least one recessed mounting pocket formed in the rear side thereof, the at least one mounting pocket having a cornice covering an upper portion thereof, wherein the freezer door is made from plastic; and b) at least one elongated baffle having opposed proximal and distal end portions, the proximal end portion of the at least one baffle including a retention flange that is dimensioned and configured for detachable reception within the at least one mounting pocket of the freezer door (310, 410) behind the cornice covering the upper portion thereof, wherein the at least one baffle is formed from molded plastic material. a) a freezer door (310, 410) having opposed front and rear sides and including at least one recessed mounting pocket formed in the rear side thereof, the at least one mounting pocket having a cornice covering an upper portion thereof, wherein the freezer door is made from plastic; and b) at least one elongated baffle having opposed proximal and distal end portions, the proximal end portion of the at least one baffle including a retention flange that is dimensioned and configured for detachable reception within the at least one mounting pocket of the freezer door (310, 410) behind the cornice covering the upper portion thereof, wherein the at least one baffle is formed from molded plastic material.
Multifunctional detector for gaseous compounds or mixtures of gaseous compounds chosen from NH 2 Cl, NHCl 2, NCl 3, total chlorine, NO x where x=1 or 2, O 3 and X 2 where X=Cl, Br or I in a sample, said detector comprising a first sensor comprising an iodide and a reactive compound chosen from starch, amylose, amylopectin, xyloglucan, xylane, chitosan, glycogen, polyvinyl alcohol or a polyvinyl alcohol compound, cellulose or a cellulose compound, α-cyclodextrin, theobromine and block polymers of polypropylene oxides and polyethylene oxides, incorporated into a block of sol-gel material that absorbs in the UV but not in the visible.
System (1, 1a) for an objective characterization of symptoms of the Parkinson's disease, said characterization occurring through an analysis of the motor status of patients affected by said Parkinson's disease, wherein said system (1, 1a) comprises: - an electronic bracelet, comprising an accelerometer, a magnetometer and a triaxial gyroscope, configured to collect data continuously about tremor and movement; - a photo-camera configured to shoot face expressions upon request of a patient; - a recorder configured to record the patient voice upon request of the patient; - a processing device configured to integrate data about movement, tremor, face and voice to identify the motor status of the patient affected by the Parkinson's disease, wherein said motor status can be in one of the following phases: * OFF phase, wherein Parkinson's symptoms, such as rigidity, tremor and bradykinesia, emerge; * ON phase, wherein said symptoms markedly improve; * DYS phase, wherein involuntary movements emerge, called dyskinesias; - a display configured to display the motor status of the patient (ON, OFF, DYS). - an electronic bracelet, comprising an accelerometer, a magnetometer and a triaxial gyroscope, configured to collect data continuously about tremor and movement; - a photo-camera configured to shoot face expressions upon request of a patient; - a recorder configured to record the patient voice upon request of the patient; - a processing device configured to integrate data about movement, tremor, face and voice to identify the motor status of the patient affected by the Parkinson's disease, wherein said motor status can be in one of the following phases: * OFF phase, wherein Parkinson's symptoms, such as rigidity, tremor and bradykinesia, emerge; * ON phase, wherein said symptoms markedly improve; * DYS phase, wherein involuntary movements emerge, called dyskinesias; * OFF phase, wherein Parkinson's symptoms, such as rigidity, tremor and bradykinesia, emerge; * ON phase, wherein said symptoms markedly improve; * DYS phase, wherein involuntary movements emerge, called dyskinesias; - a display configured to display the motor status of the patient (ON, OFF, DYS).
Method for disinfecting a space and the objects present therein, which method comprises at least the following steps of: (a) determining a first value of the relative humidity of the air in the space; (b) atomizing a disinfecting liquid in the space until a predetermined second value of the relative humidity of the air is reached in the space, and; (c) maintaining the relative humidity of the air for a predetermined time at the second value by means of atomizing the disinfecting liquid, wherein the method further comprises extracting moisture from the air in the space during atomizing of the disinfecting liquid. (a) determining a first value of the relative humidity of the air in the space; (b) atomizing a disinfecting liquid in the space until a predetermined second value of the relative humidity of the air is reached in the space, and; (c) maintaining the relative humidity of the air for a predetermined time at the second value by means of atomizing the disinfecting liquid,
A rotary connector including a stationary housing that includes an outer cylindrical body and a bottom plate portion and a movable housing that is disposed coaxially with the stationary housing and includes an inner cylindrical body facing the outer cylindrical body, an annular space portion being formed between the inner and outer cylindrical bodies (32, 21) facing each other and flat cables being wound and received in the annular space portion, wherein an internal gear is provided on an inner surface of the stationary housing, a sun gear, which is disposed coaxially with the internal gear and faces the internal gear, is provided at the inner cylindrical body of the movable housing, and a planetary gear, which meshes with the sun gear and the internal gear and rotates and revolves, is rotatably provided on the bottom plate portion, characterized in that at least one of the planetary gear, the internal gear, and the sun gear includes a plurality of void portions (10e, 11e) in a circumferential direction, so as to be elastically deformable in the radial direction, and is formed by connecting a ring-shaped outside base (10c, 11c), which includes teeth (10a, 11a) on the outer periphery thereof, to an inside base (10b, 11b), which is formed inside the outside base, with a plurality of connection portions (10d, 11d), and the plurality of void portions (10e, 11e) are formed between the plurality of connection portions (10d, 11d), respectively.
A pharmaceutical composition comprising an isolated polypeptide comprising the structure X-Fc-Y-NP-Z or the structure X-NP-Y-Fc-Z, wherein: (a) each of X and Z is, independently, absent or is an amino acid sequence of at least one amino acid; (b) the amino acid sequence of Y comprises: (i) [(Gly) 4 (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) 4] n, wherein n is between 1 and 10 and p is 0 or is between 0 and 4; (ii) the amino acid sequence of any one of SEQ ID NOs: 304-389; (iii) [(Gly) 4 (Ser)] 2; or (iv) [(Gly) m (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) m] n, wherein m is 4, n is between 1 and 6, and p is 0 or is between 0 and 20, or wherein m, n, and p are selected from a single row of Table 1; (c) said NP comprises amino acids 6-22 of SEQ ID NO:126, wherein the amino acid of said NP corresponding to position 17 of SEQ ID NO: 126 is Leu, Phe, Thr, Arg, or Tyr; and (d) said Fc is a constant domain of an immunoglobulin selected from the group consisting of IgG-1, IgG-2, IgG-3, and IgG-4. (a) each of X and Z is, independently, absent or is an amino acid sequence of at least one amino acid; (b) the amino acid sequence of Y comprises: (i) [(Gly) 4 (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) 4] n, wherein n is between 1 and 10 and p is 0 or is between 0 and 4; (ii) the amino acid sequence of any one of SEQ ID NOs: 304-389; (iii) [(Gly) 4 (Ser)] 2; or (iv) [(Gly) m (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) m] n, wherein m is 4, n is between 1 and 6, and p is 0 or is between 0 and 20, or wherein m, n, and p are selected from a single row of Table 1; (i) [(Gly) 4 (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) 4] n, wherein n is between 1 and 10 and p is 0 or is between 0 and 4; (ii) the amino acid sequence of any one of SEQ ID NOs: 304-389; (iii) [(Gly) 4 (Ser)] 2; or (iv) [(Gly) m (Ser)] n (Gly) p or (Gly) p [(Ser)(Gly) m] n, wherein m is 4, n is between 1 and 6, and p is 0 or is between 0 and 20, or wherein m, n, and p are selected from a single row of Table 1; (c) said NP comprises amino acids 6-22 of SEQ ID NO:126, wherein the amino acid of said NP corresponding to position 17 of SEQ ID NO: 126 is Leu, Phe, Thr, Arg, or Tyr; and (d) said Fc is a constant domain of an immunoglobulin selected from the group consisting of IgG-1, IgG-2, IgG-3, and IgG-4.