A compound of Formula: or a tautomer or pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body, wherein Q is pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, said Q being substituted with one to three R a wherein at least one R a is heteroaryl optionally substituted with one to three R c; Y is CR 1a R 1b, wherein R 1a is H or halo and R 1b is H or halo, optionally wherein at least one of R 1a and R 1b is F; X is O; R 2, R 3, R 4, and R 5 are independently selected from the group consisting of hydrogen, halo, R b, OR d, OC R e, SR d, CN, NO 2, CO 2 R d, CONR d R d, C R d, OC NR d R d, NR d R d, NR d C R e, NR d C 2 R e, NR d C NR d R d, S R e, S 2 R e, NR d S 2 R e, S 2 NR d R d, and N 3; or R 5 is -(CH 2) p R 5a where p is 0 or 1 and R 5a is OH; R 6 and R 7 together form oxo; each R a is independently selected from the group consisting of halo, R b, OR d, OC R e, SR d, CN, NO 2, CO 2 R d, CONR d R d, C R d, OC NR d R d, NR d C R e, NR d C 2 R d, NR d C NR d R d, S R e, S 2 R e, NR d S 2 R e, S 2 NR d R d, N 3, aryl optionally substituted with one to three R c, heteroaryl optionally substituted with one to three R c, and heterocycloalkyl optionally substituted with one to three R c; each R b is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl, each optionally independently substituted with one to three halo, OR d, or NR d R d; each R c is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, haloC 2-8 alkynyl, (CH 2) m OR f, OC R g, SR f, CN, NO 2, CO 2 R f, CONR f R f, C R f, OC NR f R f, (CH 2) m NR f R f, NR f C R g, NR f C 2 R g, NR f C NR f R f, S R g, S 2 R g, NR f S 2 R g, S 2 NR f R f, and N 3 where m is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; each R d and R f is independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl; and each R e and R g is independently selected from the group consisting of C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl. wherein Q is pyridin-2-yl, pyridin-3-yl, or pyridin-4-yl, said Q being substituted with one to three R a wherein at least one R a is heteroaryl optionally substituted with one to three R c; Y is CR 1a R 1b, wherein R 1a is H or halo and R 1b is H or halo, optionally wherein at least one of R 1a and R 1b is F; X is O; R 2, R 3, R 4, and R 5 are independently selected from the group consisting of hydrogen, halo, R b, OR d, OC R e, SR d, CN, NO 2, CO 2 R d, CONR d R d, C R d, OC NR d R d, NR d R d, NR d C R e, NR d C 2 R e, NR d C NR d R d, S R e, S 2 R e, NR d S 2 R e, S 2 NR d R d, and N 3; or R 5 is -(CH 2) p R 5a where p is 0 or 1 and R 5a is OH; R 6 and R 7 together form oxo; each R a is independently selected from the group consisting of halo, R b, OR d, OC R e, SR d, CN, NO 2, CO 2 R d, CONR d R d, C R d, OC NR d R d, NR d C R e, NR d C 2 R d, NR d C NR d R d, S R e, S 2 R e, NR d S 2 R e, S 2 NR d R d, N 3, aryl optionally substituted with one to three R c, heteroaryl optionally substituted with one to three R c, and heterocycloalkyl optionally substituted with one to three R c; each R b is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl, each optionally independently substituted with one to three halo, OR d, or NR d R d; each R c is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, haloC 2-8 alkynyl, (CH 2) m OR f, OC R g, SR f, CN, NO 2, CO 2 R f, CONR f R f, C R f, OC NR f R f, (CH 2) m NR f R f, NR f C R g, NR f C 2 R g, NR f C NR f R f, S R g, S 2 R g, NR f S 2 R g, S 2 NR f R f, and N 3 where m is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6; each R d and R f is independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl; and each R e and R g is independently selected from the group consisting of C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl.