A hemodialysis catheter assembly, which comprises: a catheter hub (12, 70, 92, 110, 158, 170) defining a passage for passage of fluids, the catheter hub (12, 70, 92, 110, 158, 170) member including a mounting collar (22, 62, 72, 112) defining an internal bore (23, 63) in fluid communication with the passage; a catheter including a catheter lumen (28, 30) extending along at least a portion of a length thereof; and a hub attachment mechanism for releasably connecting the catheter to the catheter hub (12, 70, 92, 110, 158, 170), the hub attachment mechanism including; a tube connector having a first connector end and a second connector end; and, at least one locking member (40, 60) characterized in that: the first connector end is configured for insertion within the internal bore (23, 63) of the catheter hub (12, 70, 92, 110, 158, 170); the second connector end is configured for insertion within the catheter lumen (28, 30) of the catheter; the at least one locking member (40, 60) is configured to be positionable about the second connector end of the tube connector when the second connector end is inserted within the catheter lumen (28,30) of the catheter, the at least one locking member (40, 60) adapted to compress the catheter against the second connector end of the tube connector to thereby secure the catheter to the tube connector. a catheter hub (12, 70, 92, 110, 158, 170) defining a passage for passage of fluids, the catheter hub (12, 70, 92, 110, 158, 170) member including a mounting collar (22, 62, 72, 112) defining an internal bore (23, 63) in fluid communication with the passage; a catheter including a catheter lumen (28, 30) extending along at least a portion of a length thereof; and a hub attachment mechanism for releasably connecting the catheter to the catheter hub (12, 70, 92, 110, 158, 170), the hub attachment mechanism including; a tube connector having a first connector end and a second connector end; and, at least one locking member (40, 60) characterized in that: the first connector end is configured for insertion within the internal bore (23, 63) of the catheter hub (12, 70, 92, 110, 158, 170); the second connector end is configured for insertion within the catheter lumen (28, 30) of the catheter; the at least one locking member (40, 60) is configured to be positionable about the second connector end of the tube connector when the second connector end is inserted within the catheter lumen (28,30) of the catheter, the at least one locking member (40, 60) adapted to compress the catheter against the second connector end of the tube connector to thereby secure the catheter to the tube connector. the first connector end is configured for insertion within the internal bore (23, 63) of the catheter hub (12, 70, 92, 110, 158, 170); the second connector end is configured for insertion within the catheter lumen (28, 30) of the catheter; the at least one locking member (40, 60) is configured to be positionable about the second connector end of the tube connector when the second connector end is inserted within the catheter lumen (28,30) of the catheter, the at least one locking member (40, 60) adapted to compress the catheter against the second connector end of the tube connector to thereby secure the catheter to the tube connector.