A desalination system, comprising: a desalination platform; a first skid (102, 302) disposed on a first deck of the desalination platform, the first skid (102, 302) comprising at least one of a first filtration unit configured to produce a first filtrate stream, and a first permeate unit configured to produce a first permeate stream; a first interconnecting pipework coupled to the first skid (102, 302); and a first pipework support disposed on the first deck, wherein the first interconnecting pipework is disposed on the first pipework support; a first support structure (160, 370) comprising a first upper frame (162, 372) positioned at a top (106A, 306A) of the first skid (102, 302) and a first lower frame (166, 376) positioned at a base (106B, 306B) of the first skid (102, 302); a first inlet pipework (114, 314) coupled between a first inlet valve (115, 315) and the at least one of the first filtration unit and the first permeate unit, wherein the at least one of the first filtration unit and the first permeate unit is supported by the first support structure (160, 370), wherein the at least one of the first filtration unit and the first permeate unit is configured to produce the first filtrate stream or the first permeate stream, respectively, from an inlet stream supplied to the first inlet valve (115, 315); and a first discharge pipework (136, 338) coupled between the at least one of the first filtration unit and the first permeate unit and a first discharge valve (138, 323); and wherein the first inlet valve (115, 315) and the first discharge valve (138, 323) are each directly supported by the first lower frame (166, 376) of the first support structure (160, 370). a desalination platform; a first skid (102, 302) disposed on a first deck of the desalination platform, the first skid (102, 302) comprising at least one of a first filtration unit configured to produce a first filtrate stream, and a first permeate unit configured to produce a first permeate stream; a first interconnecting pipework coupled to the first skid (102, 302); and a first pipework support disposed on the first deck, wherein the first interconnecting pipework is disposed on the first pipework support; a first support structure (160, 370) comprising a first upper frame (162, 372) positioned at a top (106A, 306A) of the first skid (102, 302) and a first lower frame (166, 376) positioned at a base (106B, 306B) of the first skid (102, 302); a first inlet pipework (114, 314) coupled between a first inlet valve (115, 315) and the at least one of the first filtration unit and the first permeate unit, wherein the at least one of the first filtration unit and the first permeate unit is supported by the first support structure (160, 370), wherein the at least one of the first filtration unit and the first permeate unit is configured to produce the first filtrate stream or the first permeate stream, respectively, from an inlet stream supplied to the first inlet valve (115, 315); and a first discharge pipework (136, 338) coupled between the at least one of the first filtration unit and the first permeate unit and a first discharge valve (138, 323); and wherein the first inlet valve (115, 315) and the first discharge valve (138, 323) are each directly supported by the first lower frame (166, 376) of the first support structure (160, 370).