A compound, or salt or a tautomer thereof, according to Formula: Wherein is a single or double bond; X is N or CH; Y is N, O or S; one occurrence of R is cyano and the other occurrence of R is hydrogen or R 4; R 1 is halogen, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, aminoC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, C 3 -C 6 cycloalkylC 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, S p C 1 -C 6 alkyl, CH 2 NHC C 1 -C 4 alkyl or OCH 2 C R 7, p is 0, 1, or 2; R 2 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyC 1 -C 6 alkyl or halogen; R 3 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, CH 2 C R 7, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups, and wherein alkyl and haloalkyl optionally substituted with 0 or 1 hydroxy; R 4 is 0, 1, or 2 substitutents independently selected at each occurrence from halogen and C 1 -C 6 alkyl; R 5 is hydrogen, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S; or R 3 and R 5 taken in combination form a divalent -CH 2 -CH 2 - or -CH 2 -N - group; R 6 is hydrogen, hydroxy, amino, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, mono- and di-C 1 -C 4 alkylamino, amino C 1 -C 6 alkylamino, [CR A 2] n R 7, [CR A 2] n C R 7, O[CR A 2] n R 7, NHC C 1 -C 6 alkyl, NHS(O 2)C 1 -C 6 alkyl, (CH 2) n R 9, O(CH 2) n R 9, C R 7, N [CR A 2] n R 7, O[CR A 2] n C R 7, N [CR A 2] n C R 7 or tetrazolyl; or CR 5 R 6, taken in combination, form a divalent carbonyl group, a divalent =CH 2 group or cyclopropyl which cyclopropyl is optionally substituted by CO 2 H or CH 2 OH; n is 1, 2, 3 or 4; R A is independently selected at each occurrence from hydrogen, halogen or C 1 -C 4 alkyl; R 7 is hydroxy, C 1 -C 4 alkoxy, amino or mono- and di-C 1 -C 4 alkylamino R 8 is hydrogen or halogen; and R 9 is a 5 member heteroaryl having 1 to 4 ring heteroatoms selected from N, O or S and optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups. is a single or double bond; X is N or CH; Y is N, O or S; one occurrence of R is cyano and the other occurrence of R is hydrogen or R 4; R 1 is halogen, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, aminoC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, C 3 -C 6 cycloalkylC 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, S p C 1 -C 6 alkyl, CH 2 NHC C 1 -C 4 alkyl or OCH 2 C R 7, p is 0, 1, or 2; R 2 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyC 1 -C 6 alkyl or halogen; R 3 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, CH 2 C R 7, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups, and wherein alkyl and haloalkyl optionally substituted with 0 or 1 hydroxy; R 4 is 0, 1, or 2 substitutents independently selected at each occurrence from halogen and C 1 -C 6 alkyl; R 5 is hydrogen, C 1 -C 6 alkyl, haloC 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S; or R 3 and R 5 taken in combination form a divalent -CH 2 -CH 2 - or -CH 2 -N - group; R 6 is hydrogen, hydroxy, amino, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, mono- and di-C 1 -C 4 alkylamino, amino C 1 -C 6 alkylamino, [CR A 2] n R 7, [CR A 2] n C R 7, O[CR A 2] n R 7, NHC C 1 -C 6 alkyl, NHS(O 2)C 1 -C 6 alkyl, (CH 2) n R 9, O(CH 2) n R 9, C R 7, N [CR A 2] n R 7, O[CR A 2] n C R 7, N [CR A 2] n C R 7 or tetrazolyl; or CR 5 R 6, taken in combination, form a divalent carbonyl group, a divalent =CH 2 group or cyclopropyl which cyclopropyl is optionally substituted by CO 2 H or CH 2 OH; n is 1, 2, 3 or 4; R A is independently selected at each occurrence from hydrogen, halogen or C 1 -C 4 alkyl; R 7 is hydroxy, C 1 -C 4 alkoxy, amino or mono- and di-C 1 -C 4 alkylamino R 8 is hydrogen or halogen; and R 9 is a 5 member heteroaryl having 1 to 4 ring heteroatoms selected from N, O or S and optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups.