A laparoscopic clip applier comprising: a proximal handle configured for controlling a position of a distal most clip inside the subject; a rigid sleeve (108, 178) extending from said handle; a trigger connected to said sleeve (108, 178) to advance said sleeve (108, 178) distally with respect to said handle and to retract said sleeve (108, 178) proximally with respect to said handle in response to moving said trigger with respect to said handle in first direction and second direction opposite said first direction respectively; multiple interconnected clips (102, 172), each clip of said multiple interconnected clips being normally-open by a proximal spring integral to the clip (102, 172), wherein each clip is (102, 172) housed in said sleeve (108, 178), and wherein each clip (102, 172) is provided with a self-locking mechanism (114, 1114) at its distal end, and wherein each said clip (102, 172), when housed within said sleeve (108, 178), is closed and unlocked; and a pusher operable by said handle and configured to move with respect to said handle, to: advance said multiple interconnected clips (102, 172) distally with respect to said handle and to position a most distally-positioned clip (102, 172) of said multiple interconnected clips (102, 172) into a deployment position, wherein retracting said sleeve with said trigger exposes said most distally-positioned clip (102, 172) from said distal end of said sleeve (108, 178) and causes said most distally-positioned clip (102, 172) to open while remaining in said deployment position axially stationary with respect to said handle, wherein advancing said sleeve (108, 178) with said trigger while said pusher retains said exposed most distally positioned clip (102, 172) in said deployment position axially stationary with respect to the handle, closes said exposed clip (102, 172) over a bodily tissue until said self-locking mechanism (114, 1114) of said exposed most distally positioned clip (102, 172) engages, thereby deploying said exposed most distally positioned clip (102, 172). a proximal handle configured for controlling a position of a distal most clip inside the subject; a rigid sleeve (108, 178) extending from said handle; a trigger connected to said sleeve (108, 178) to advance said sleeve (108, 178) distally with respect to said handle and to retract said sleeve (108, 178) proximally with respect to said handle in response to moving said trigger with respect to said handle in first direction and second direction opposite said first direction respectively; multiple interconnected clips (102, 172), each clip of said multiple interconnected clips being normally-open by a proximal spring integral to the clip (102, 172), wherein each clip is (102, 172) housed in said sleeve (108, 178), and wherein each clip (102, 172) is provided with a self-locking mechanism (114, 1114) at its distal end, and wherein each said clip (102, 172), when housed within said sleeve (108, 178), is closed and unlocked; and wherein each clip is (102, 172) housed in said sleeve (108, 178), and wherein each clip (102, 172) is provided with a self-locking mechanism (114, 1114) at its distal end, and wherein each said clip (102, 172), when housed within said sleeve (108, 178), is closed and unlocked; and a pusher operable by said handle and configured to move with respect to said handle, to: advance said multiple interconnected clips (102, 172) distally with respect to said handle and to position a most distally-positioned clip (102, 172) of said multiple interconnected clips (102, 172) into a deployment position, wherein retracting said sleeve with said trigger exposes said most distally-positioned clip (102, 172) from said distal end of said sleeve (108, 178) and causes said most distally-positioned clip (102, 172) to open while remaining in said deployment position axially stationary with respect to said handle, wherein advancing said sleeve (108, 178) with said trigger while said pusher retains said exposed most distally positioned clip (102, 172) in said deployment position axially stationary with respect to the handle, closes said exposed clip (102, 172) over a bodily tissue until said self-locking mechanism (114, 1114) of said exposed most distally positioned clip (102, 172) engages, thereby deploying said exposed most distally positioned clip (102, 172). advance said multiple interconnected clips (102, 172) distally with respect to said handle and to position a most distally-positioned clip (102, 172) of said multiple interconnected clips (102, 172) into a deployment position, wherein retracting said sleeve with said trigger exposes said most distally-positioned clip (102, 172) from said distal end of said sleeve (108, 178) and causes said most distally-positioned clip (102, 172) to open while remaining in said deployment position axially stationary with respect to said handle, wherein advancing said sleeve (108, 178) with said trigger while said pusher retains said exposed most distally positioned clip (102, 172) in said deployment position axially stationary with respect to the handle, closes said exposed clip (102, 172) over a bodily tissue until said self-locking mechanism (114, 1114) of said exposed most distally positioned clip (102, 172) engages, thereby deploying said exposed most distally positioned clip (102, 172).