mhurhangee/ep-ind-claims huggingface dataset:
An antibody having the ability of binding to CLD18A2 and mediating killing of cells expressing CLD18A2, wherein said antibody comprises a heavy chain variable domain and a light chain variable domain comprising a set of complementarity-determining regions CDR1, CDR2 and CDR3 selected from the following sets (i) to (v): (i) VH: CDR1: positions 45-52 of SEQ ID NO: 115, CDR2: positions 70-77 of SEQ ID NO: 115, CDR3: positions 116-125 of SEQ ID NO: 115, VL: CDR1: positions 49-53 of SEQ ID NO: 122, CDR2: positions 71-73 of SEQ ID NO: 122, CDR3: positions 110-118 of SEQ ID NO: 122, (ii) VH: CDR1: positions 45-52 of SEQ ID NO: 116, CDR2: positions 70-77 of SEQ ID NO: 116, CDR3: positions 116-126 of SEQ ID NO: 116, VL: CDR1: positions 47-58 of SEQ ID NO: 121, CDR2: positions 76-78 of SEQ ID NO: 121, CDR3: positions 115-123 of SEQ ID NO: 121, (iii) VH: CDR1: positions 45-52 of SEQ ID NO: 117, CDR2: positions 70-77 of SEQ ID NO: 117, CDR3: positions 116-124 of SEQ ID NO: 117, VL: CDR1: positions 47-52 of SEQ ID NO: 123, CDR2: positions 70-72 of SEQ ID NO: 123, CDR3: positions 109-117 of SEQ ID NO: 123, (iv) VH: CDR1: positions 44-51 of SEQ ID NO: 119, CDR2: positions 69-76 of SEQ ID NO: 119, CDR3: positions 115-125 of SEQ ID NO: 119, VL: CDR1: positions 47-58 of SEQ ID NO: 126, CDR2: positions 76-78 of SEQ ID NO: 126, CDR3: positions 115-122 of SEQ ID NO: 126, and (v) VH: CDR1: positions 45-52 of SEQ ID NO: 118, CDR2: positions 70-77 of SEQ ID NO: 118, CDR3: positions 116-126 of SEQ ID NO: 118, VL: CDR1: positions 47-58 of SEQ ID NO: 125, CDR2: positions 76-78 of SEQ ID NO: 125, CDR3: positions 115-123 of SEQ ID NO: 125, wherein the VH and VL domains of the antibody are expressed on a single polypeptide chain. (i) VH: CDR1: positions 45-52 of SEQ ID NO: 115, CDR2: positions 70-77 of SEQ ID NO: 115, CDR3: positions 116-125 of SEQ ID NO: 115, VL: CDR1: positions 49-53 of SEQ ID NO: 122, CDR2: positions 71-73 of SEQ ID NO: 122, CDR3: positions 110-118 of SEQ ID NO: 122, (ii) VH: CDR1: positions 45-52 of SEQ ID NO: 116, CDR2: positions 70-77 of SEQ ID NO: 116, CDR3: positions 116-126 of SEQ ID NO: 116, VL: CDR1: positions 47-58 of SEQ ID NO: 121, CDR2: positions 76-78 of SEQ ID NO: 121, CDR3: positions 115-123 of SEQ ID NO: 121, (iii) VH: CDR1: positions 45-52 of SEQ ID NO: 117, CDR2: positions 70-77 of SEQ ID NO: 117, CDR3: positions 116-124 of SEQ ID NO: 117, VL: CDR1: positions 47-52 of SEQ ID NO: 123, CDR2: positions 70-72 of SEQ ID NO: 123, CDR3: positions 109-117 of SEQ ID NO: 123, (iv) VH: CDR1: positions 44-51 of SEQ ID NO: 119, CDR2: positions 69-76 of SEQ ID NO: 119, CDR3: positions 115-125 of SEQ ID NO: 119, VL: CDR1: positions 47-58 of SEQ ID NO: 126, CDR2: positions 76-78 of SEQ ID NO: 126, CDR3: positions 115-122 of SEQ ID NO: 126, and (v) VH: CDR1: positions 45-52 of SEQ ID NO: 118, CDR2: positions 70-77 of SEQ ID NO: 118, CDR3: positions 116-126 of SEQ ID NO: 118, VL: CDR1: positions 47-58 of SEQ ID NO: 125, CDR2: positions 76-78 of SEQ ID NO: 125, CDR3: positions 115-123 of SEQ ID NO: 125,
Gas chromatograph having an oven, an oven door, via which the oven chamber of the oven is accessible, a separating column arranged in the oven chamber for separating materials, a heating device for heating the oven chamber and a cooling device for cooling the oven chamber, wherein the cooling device is a cooling unit having a coolant cycle with a side receiving heat and a side giving off heat, and wherein the coolant cycle is closed in relation to the oven chamber characterized in, that the gas chromatograph is comprised of a carrier gas port, an injector for sending the sample into the separating column and a connector for a detector at the outlet of the separating column, that the side of the cooling device receiving heat is arranged on the inside of the oven door, and that an inflow side connector and an outflow side connector of a heat exchanger receiving heat are lead through the oven door, so that the heat exchanger receiving heat is accessible from outside of the oven and from outside of the gas chromatograph and the coolant cycle of the cooling unit can be closed from outside of the gas chromatograph.
A handpiece for a medical device, comprising: - an attachment structure along a front end of the handpiece configured for removably coupling to a medical instrument; and - a housing comprising: - a top surface defining at least one hole capable of receiving at least one button (41, 42, 51, 52) for controlling a function of the medical device; - a bottom base; and - an extension portion connected to the base and extending downwardly therefrom, the extension portion including a shoulder connected to the base by a narrowed neck portion, the base, the shoulder and the narrowed neck portion defining a concave shaped surface capable of receiving an operator's finger, characterized in that the housing further includes a rear protrusion located along a rear portion of the shoulder, said rear protrusion including a wire retention structure extending upwardly from a top surface of the rear protrusion itself. - an attachment structure along a front end of the handpiece configured for removably coupling to a medical instrument; and - a housing comprising: - a top surface defining at least one hole capable of receiving at least one button (41, 42, 51, 52) for controlling a function of the medical device; - a bottom base; and - an extension portion connected to the base and extending downwardly therefrom, the extension portion including a shoulder connected to the base by a narrowed neck portion, the base, the shoulder and the narrowed neck portion defining a concave shaped surface capable of receiving an operator's finger, - a top surface defining at least one hole capable of receiving at least one button (41, 42, 51, 52) for controlling a function of the medical device; - a bottom base; and - an extension portion connected to the base and extending downwardly therefrom, the extension portion including a shoulder connected to the base by a narrowed neck portion, the base, the shoulder and the narrowed neck portion defining a concave shaped surface capable of receiving an operator's finger,
Gas seal, in particular dry gas seal, which extends in a circumferential direction with respect to an axis, comprising a rotating slide ring and a stationary slide ring, wherein the stationary slide ring is axially movable, wherein the gas seal comprises a slide sleeve, wherein, by means of a first slide surface, the slide sleeve radially guides the stationary slide ring on a second slide surface along the axial direction of mobility, characterized in that the slide sleeve is fastened to a stator of the gas seal, wherein the slide sleeve has a first recess, extending in the circumferential direction, and the stator has a second recess, extending in the circumferential direction and situated opposite the first recess in the region of the fastening, such that the first recess and the second recess define a common cavity, which extends in the circumferential direction in an annular manner, wherein, in the cavity, there is arranged an elongate fixing element which at least partially fills the first recess and second recess such that an unlimited axial relative movement is possible only when the fixing element is radially deformed.
Wheel rim, said rim comprising an annular body made in one piece with a central annular portion, two peripheral annular portions and two intermediate annular portions, said central annular portion extending around an axis and being configured for arrangement around a wheel hub, said two peripheral annular portions being located on two sides that are axially opposite said central annular portion, each peripheral annular portion being more distant from said axis than said central annular portion and being configured for coupling with a bead of a tyre, each intermediate annular portion being arranged to join said central annular portion to a respective peripheral annular portion, each intermediate annular portion comprising a tilted wall, a central connecting wall that joins said tilted wall to said central annular portion, and a peripheral connecting wall that joins said tilted wall to the respective peripheral annular portion, said peripheral connecting wall being more distant from said axis than said central connecting wall, said tilted wall comprising a frustoconical surface facing radially outwards, where "radially" is intended with reference to said axis; wherein said frustoconical surface of said tilted wall forms an angle α included in the range α = 50° ± 4° with a plane that is perpendicular to said axis and wherein said central connecting wall comprises a convex annular surface facing radially outwards and connected on one side to said frustoconical surface of said tilted wall and on one axially opposite side to said central annular portion; characterized in that: - said peripheral connecting wall comprises a frustoconical surface facing radially outwards and forming an angle β comprised in the range β = 5° ± 3° with a direction parallel to said axis; - said tilted wall has a thickness S2 and said frustoconical surface of said peripheral connecting wall is connected to said frustoconical surface of said tilted wall by means of an annular connecting surface with a radius of curvature R2, being 1.5 * S2 < R2 < 2.5 * S2. - said peripheral connecting wall comprises a frustoconical surface facing radially outwards and forming an angle β comprised in the range β = 5° ± 3° with a direction parallel to said axis; - said tilted wall has a thickness S2 and said frustoconical surface of said peripheral connecting wall is connected to said frustoconical surface of said tilted wall by means of an annular connecting surface with a radius of curvature R2, being 1.5 * S2 < R2 < 2.5 * S2.
A method for reducing power consumption in an Ethernet communication device comprising: upon receiving a predetermined number of consecutive idle frames, initiating a silent period having a reduced power consumption state in which frames are not processed; and repeatedly performing the steps of: after a predetermined amount of time, receiving a sync frame or an idle frame; processing the received frame to adapt settings of the Ethernet communication device; and re-initiating the silent period having the reduced power consumption state in which frames are not processed, wherein the processing comprises: analyzing the received frame to determine channel conditions; comparing the determined channel conditions with prior channel conditions; and adapting the settings of the Ethernet communication device in response to the comparing revealing a change in channel conditions greater than a threshold. upon receiving a predetermined number of consecutive idle frames, initiating a silent period having a reduced power consumption state in which frames are not processed; and repeatedly performing the steps of: after a predetermined amount of time, receiving a sync frame or an idle frame; processing the received frame to adapt settings of the Ethernet communication device; and re-initiating the silent period having the reduced power consumption state in which frames are not processed, wherein the processing comprises: analyzing the received frame to determine channel conditions; comparing the determined channel conditions with prior channel conditions; and adapting the settings of the Ethernet communication device in response to the comparing revealing a change in channel conditions greater than a threshold. after a predetermined amount of time, receiving a sync frame or an idle frame; processing the received frame to adapt settings of the Ethernet communication device; and re-initiating the silent period having the reduced power consumption state in which frames are not processed, wherein the processing comprises: analyzing the received frame to determine channel conditions; comparing the determined channel conditions with prior channel conditions; and adapting the settings of the Ethernet communication device in response to the comparing revealing a change in channel conditions greater than a threshold. analyzing the received frame to determine channel conditions; comparing the determined channel conditions with prior channel conditions; and adapting the settings of the Ethernet communication device in response to the comparing revealing a change in channel conditions greater than a threshold.
A method of transmission that facilitates accurate decoding of a Physical Downlink Control Channel, PDCCH by one or more user equipments, UEs, comprising: identifying an aggregation level for each of the one or more UEs; generating scrambling sequences determined by the aggregation level for each of the one or more UEs; scrambling cyclic redundancy check, CRC bits of PDCCH transmissions for the one or more UEs using the respective generated scrambling sequence; and transmitting the scrambled CRC bits in the PDCCH transmissions to the one or more UEs. identifying an aggregation level for each of the one or more UEs; generating scrambling sequences determined by the aggregation level for each of the one or more UEs; scrambling cyclic redundancy check, CRC bits of PDCCH transmissions for the one or more UEs using the respective generated scrambling sequence; and transmitting the scrambled CRC bits in the PDCCH transmissions to the one or more UEs.
A method for implementing service operations based on images, the method comprising: receiving an image sharing request sent by a first user, the image request including one or more images to be shared; storing attribute information comprised in the image sharing request, wherein the attribute information comprises first location information of the one or more images and text information entered by the first user when the first user shares the one or more images; searching, based on the first location information and the text information, a database for a service object associated with the one or more images, the searching comprising: searching the database for a service object that matches the first location information to determine a matching service object, and only when a plurality of service objects are found, additionally matching the text information against the respective information about each found service object to determine the matching service object, and determining that the determined matching service object is the service object that is associated with the one or more images; pushing the one or more images to a second user associated with the user; and sending information about the matching service object to the second user based on a predetermined policy. receiving an image sharing request sent by a first user, the image request including one or more images to be shared; storing attribute information comprised in the image sharing request, wherein the attribute information comprises first location information of the one or more images and text information entered by the first user when the first user shares the one or more images; searching, based on the first location information and the text information, a database for a service object associated with the one or more images, the searching comprising: searching the database for a service object that matches the first location information to determine a matching service object, and only when a plurality of service objects are found, additionally matching the text information against the respective information about each found service object to determine the matching service object, and determining that the determined matching service object is the service object that is associated with the one or more images; searching the database for a service object that matches the first location information to determine a matching service object, and only when a plurality of service objects are found, additionally matching the text information against the respective information about each found service object to determine the matching service object, and determining that the determined matching service object is the service object that is associated with the one or more images; pushing the one or more images to a second user associated with the user; and sending information about the matching service object to the second user based on a predetermined policy.
A holder for a head replacement-type cutting tool in which a replacement-type cutting head having a cutting part is to be attached to an attachment hole of the holder in a detachable manner to constitute a head replacement-type cutting tool, the holder for a head replacement-type cutting tool comprising: a holder main body; and a tubular coupling member which is housed in the attachment hole formed in the holder main body and made of a metal material with a lower hardness than the holder main body, wherein the coupling member is provided with an attachment screw part which is to be screwed to a head-side screw part formed on the replacement-type cutting head, characterised in that, a recessed part is formed on an inner circumferential face of the attachment hole, the coupling member is engaged with the recessed part by plastic deformation so that an outer circumferential face of the coupling member is firmly attached to the inner circumferential face of the attachment hole. a holder main body; and a tubular coupling member which is housed in the attachment hole formed in the holder main body and made of a metal material with a lower hardness than the holder main body, wherein the coupling member is provided with an attachment screw part which is to be screwed to a head-side screw part formed on the replacement-type cutting head, characterised in that, a recessed part is formed on an inner circumferential face of the attachment hole, the coupling member is engaged with the recessed part by plastic deformation so that an outer circumferential face of the coupling member is firmly attached to the inner circumferential face of the attachment hole.
A communication method for transmitting information from a first device to a second device, comprising the following steps: - transmitting a signal from the first device to the second device, - in response to the signal being received by the second device, transmitting a request from the second device to a computer system to transmit the information to the second device, - authenticating the first device and the computer system to one another, - transmitting the information from the first device to the computer system, wherein a connection with end-to-end encryption is established between a security module of the first device and the computer system, wherein the computer system reads the information from the security module, in which information is stored, via the protected connection, wherein a precondition for the reading of the information is the prior authentication, - signing the information by the computer system, - transmitting the information and signature thereof to the second device. - transmitting a signal from the first device to the second device, - in response to the signal being received by the second device, transmitting a request from the second device to a computer system to transmit the information to the second device, - authenticating the first device and the computer system to one another, - transmitting the information from the first device to the computer system, wherein a connection with end-to-end encryption is established between a security module of the first device and the computer system, wherein the computer system reads the information from the security module, in which information is stored, via the protected connection, wherein a precondition for the reading of the information is the prior authentication, - signing the information by the computer system, - transmitting the information and signature thereof to the second device.
Device for dispensing products, in particular food products, comprising a rotary shutter, which has a first duct having an input and an output and which is capable of being moved rotationally with respect to a shuttering element in order to position the output of the first duct facing a dispensing hole or facing a masking area of the shuttering element, characterised in that the rotary shutter has a second duct, separate from the first duct and having an input and an output, and in that the outputs (28B, 30B) of the first and second ducts (28, 30) are arranged in the same face of the rotary shutter and spaced apart from one another so that the rotary shutter is capable of occupying a rest position (Fig. 4) in which the outputs of the two ducts face the masking area, a first dispensing position (Fig. 5) in which the output of the first duct faces the dispensing hole whilst the output of the second duct faces the masking area and a second dispensing position (Fig. 6) in which the output of the second duct faces the dispensing hole whilst the output of the first duct faces the masking area, the inputs (20A, 30A) of said ducts being capable of being supplied with products to be dispensed in the first and second dispensing positions, and in that, from its rest position, the rotary shutter is capable of being controlled in two opposite directions of rotation (S1, S2) in order to adopt the first or the second dispensing position, whereas, from one of the dispensing positions, the rotary shutter is capable of being controlled solely in the direction of its rotation (R1, R2) towards its rest position.
An inoculant for the manufacture of cast iron with lamellar, compacted or spheroidal graphite wherein said inoculant comprises a particulate ferrosilicon alloy comprising between about 40 to 80 wt% silicon, between about 0.1 to 10 wt% calcium, between 0 and 10 % by weight of rare earths, and up to 5 wt% aluminium the balance being iron and incidental impurities in the ordinary amount, wherein said inoculant additionally comprises 0.1 to 10 wt% Sb 2 O 3, based on the total weight of inoculant, where said Sb 2 O 3 is in particulate form.
A method of operating an electric vehicle including a gearbox coupling an electric motor to a drive wheel, comprising: initiating a gear shift of the gearbox, said gear shift being from a first configuration of gears to a second configuration of gears through a neutral configuration, wherein in the first and second configurations the electric motor is operatively coupled to the drive wheel with different gear ratios, and in the neutral configuration, the electric motor is operatively decoupled from the drive wheel; and activating a torque jog in the electric motor, wherein the torque jog results in a fluctuation in torque output by the electric motor, characterized in that, the method comprises: activating the torque jog in the electric motor to assist with gear disengagement when shifting to the neutral configuration, wherein the torque jog is activated: substantially simultaneously with initiating the gear shift, or a predetermined time after initiating the gear shift. initiating a gear shift of the gearbox, said gear shift being from a first configuration of gears to a second configuration of gears through a neutral configuration, wherein in the first and second configurations the electric motor is operatively coupled to the drive wheel with different gear ratios, and in the neutral configuration, the electric motor is operatively decoupled from the drive wheel; and activating a torque jog in the electric motor, wherein the torque jog results in a fluctuation in torque output by the electric motor, characterized in that, the method comprises: activating the torque jog in the electric motor to assist with gear disengagement when shifting to the neutral configuration, wherein the torque jog is activated: substantially simultaneously with initiating the gear shift, or a predetermined time after initiating the gear shift. substantially simultaneously with initiating the gear shift, or a predetermined time after initiating the gear shift.
A composition comprising temozolomide for use in the treatment of melanoma wherein the treatment comprises administration orally of carboxyamidotriazole orotate and wherein the temozolomide is administered orally at a dose of 60 mg/kg/Q4Dx3, and wherein the carboxyamidotriazole orotate is administered at a dose of 342 mg/kg/day.