mhurhangee/ep-ind-claims huggingface dataset:
Method for producing an immunoglobulin single variable domain in a yeast, comprising A) applying conditions that promote the formation of disulfide bridges in immunoglobulin single variable domains, or B) removing immunoglobulin single variable domains lacking at least one disulfide bridge by applying conditions selected from i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or C) a combination of and, wherein the conditions that promote the formation of disulfide bridges are selected from one or more of the following: a) addition of oxidizing metal ions to at least one production step selected from: the culture broth after fermentation, the supernatant comprising the immunoglobulin single variable domain after removal of the host, any step after purification of the immunoglobulin single variable domain, or the purified immunoglobulin single variable domain or b) addition of Cu2+ to a final concentration of 1 to 10 mM. A) applying conditions that promote the formation of disulfide bridges in immunoglobulin single variable domains, or B) removing immunoglobulin single variable domains lacking at least one disulfide bridge by applying conditions selected from i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or C) a combination of and, a) addition of oxidizing metal ions to at least one production step selected from: the culture broth after fermentation, the supernatant comprising the immunoglobulin single variable domain after removal of the host, any step after purification of the immunoglobulin single variable domain, or the purified immunoglobulin single variable domain or b) addition of Cu2+ to a final concentration of 1 to 10 mM.
A composition comprising a plurality of ligand-drug conjugates of Formula IIa or lib wherein L is an antibody or an antigen-binding fragment thereof; p is an integer from 1 to 10; and wherein the compound of Formula IIa or lib is present in a diastereomeric excess of greater than 50% relative to a diastereomer having a different stereochemical configuration at a chiral carbon, wherein the chiral carbon atom is the carbon atom that is bound to the sulfur atom in Formula IIa or IIb. L is an antibody or an antigen-binding fragment thereof; p is an integer from 1 to 10; and wherein the compound of Formula IIa or lib is present in a diastereomeric excess of greater than 50% relative to a diastereomer having a different stereochemical configuration at a chiral carbon, wherein the chiral carbon atom is the carbon atom that is bound to the sulfur atom in Formula IIa or IIb.
A method for executing by a circuit an operation receiving an input data and providing an output data, the method comprising: selecting a substitution element (T2[i,0..r]) in a substitution table as a function of the input data, the substitution element being a first data set, each substitution element in the substitution table that can be selected as a function of an input substitution data, being a data set, and providing the first data set as an intermediary result or a final result of the operation, the first data set including the output data, and being such that in a set of transformed data resulting from the application of a chosen surjective function to the first data set, the transformed output data occurs with a probability equal to the probability of occurrence of each transformed data resulting from the application of the surjective function to the other data in the first data set, the output data having a position in the first data set which is known by the circuit. selecting a substitution element (T2[i,0..r]) in a substitution table as a function of the input data, the substitution element being a first data set, each substitution element in the substitution table that can be selected as a function of an input substitution data, being a data set, and providing the first data set as an intermediary result or a final result of the operation, the first data set including the output data, and being such that in a set of transformed data resulting from the application of a chosen surjective function to the first data set, the transformed output data occurs with a probability equal to the probability of occurrence of each transformed data resulting from the application of the surjective function to the other data in the first data set, the output data having a position in the first data set which is known by the circuit.
A gas turbine engine having an engine axis, the engine comprising: a gas generator that includes a core flow path providing air to a compressor section of the gas turbine engine; a propulsor that includes a fan and geared architecture for driving the fan; and a housing defining a first compartment that separates the geared architecture and the core flow path, the housing including a first side section proximal to a fan rotor of the gas turbine engine and a second side section proximal to a low pressure compressor bearing of the gas turbine engine and a shielded axial mid-section located between the first side section and the second side section that provides a common wall between the first compartment and the core flow path, wherein the shielded axial mid-section includes an outer layer and an insulator adjacent to the outer layer. a gas generator that includes a core flow path providing air to a compressor section of the gas turbine engine; a propulsor that includes a fan and geared architecture for driving the fan; and a housing defining a first compartment that separates the geared architecture and the core flow path, the housing including a first side section proximal to a fan rotor of the gas turbine engine and a second side section proximal to a low pressure compressor bearing of the gas turbine engine and a shielded axial mid-section located between the first side section and the second side section that provides a common wall between the first compartment and the core flow path, wherein the shielded axial mid-section includes an outer layer and an insulator adjacent to the outer layer.
Electrical winding form comprising electrically conductive windings around a core, where the cavities between the windings are filled in a form-fitting manner by a thermoplastic material, wherein the thermoplastic material comprises a mixture of a) a network-forming thermoplastic elastomer which, in the range of 120-150 °C, has very good flowability and a melt flow index of at least 15 g/10 min (190 °C/2.16 kg, measured to ISO 1133-1) and b) a phase change material having a phase change temperature between 40 °C and 140 °C, wherein the phase change material is present in the thermoplastic material in a proportion of 50 % to 85 % by weight. a) a network-forming thermoplastic elastomer which, in the range of 120-150 °C, has very good flowability and a melt flow index of at least 15 g/10 min (190 °C/2.16 kg, measured to ISO 1133-1) and b) a phase change material having a phase change temperature between 40 °C and 140 °C, wherein the phase change material is present in the thermoplastic material in a proportion of 50 % to 85 % by weight.
Continuous packaging process using UV-C light to sterilise the inside of bottles and closure caps intended to contain alimentary, cosmetic and pharmaceutical products, characterised in that it comprises the following sequence of stages: a) preliminary bottle preparation and/or formation; b) introducing the bottles with a cap into a tunnel or cabin, wherein the bottles are submitted to a micro-filtered, over pressurized air flow, at a pressure greater than or equal to 50 KPa in a laminar regime and a set of UV-C lamps irradiates on the entire internal surface of the cabin or tunnel and the external surface of the bottles; c) removing the caps by means of a robotic or mechanical arm; d) introducing a UV-C emitting lamp inside each bottle, the lamp being formed with a narrow thickness in order to irradiate the entire internal surface of the bottles, thereby preventing blind spots; e) filling the container with the alimentary, cosmetic or pharmaceutical product through an aseptic watertight valve; f) irradiating the internal surface of the caps with UV light whilst they are moved along an open channel; g) closing the bottles with the irradiated caps, by means of a robotic or mechanised arm. a) preliminary bottle preparation and/or formation; b) introducing the bottles with a cap into a tunnel or cabin, wherein the bottles are submitted to a micro-filtered, over pressurized air flow, at a pressure greater than or equal to 50 KPa in a laminar regime and a set of UV-C lamps irradiates on the entire internal surface of the cabin or tunnel and the external surface of the bottles; c) removing the caps by means of a robotic or mechanical arm; d) introducing a UV-C emitting lamp inside each bottle, the lamp being formed with a narrow thickness in order to irradiate the entire internal surface of the bottles, thereby preventing blind spots; e) filling the container with the alimentary, cosmetic or pharmaceutical product through an aseptic watertight valve; f) irradiating the internal surface of the caps with UV light whilst they are moved along an open channel; g) closing the bottles with the irradiated caps, by means of a robotic or mechanised arm.
Method for checking the presence of incondensable gases in an air conditioning recharging station, characterized in that it provides for the determination of the presence of incondensable gases inside the tank of the station by using one of the sensors (LP, HP) present in the charging station and adapted to monitor the recovery and recharging operations of the air conditioning system of a motor vehicle; a control unit of the station is configured to open at least one refrigerant charging valve and at least one separation valve of high pressure and low pressure lines (19, 13) of the station so as to form a closed circuit (19, 13, 33); once the circuit has been formed, the pure refrigerant in liquid phase flows from tank to the circuit, coming into contact with at least one pressure sensor placed on the high or low pressure lines of the station and normally used to monitor the progress of the refrigerant recovery and charging operations; the refrigerant pressure value is measured by said sensor and the unit checks the presence of incondensable gases, using said value for comparison with a liquid-vapor equilibrium line of the pure refrigerant contained in the tank.
A method for controlling a refrigeration system of a vehicle, the refrigeration system comprising a circuit containing a refrigerant, a compressor, and a first evaporator and a second evaporator which are connected in parallel to the compressor, and a first expansion valve arranged upstream the first evaporator, which first expansion valve regulates a pressure drop of the refrigerant before the first evaporator, and a second expansion valve arranged upstream the second evaporator, which second expansion valve regulates a pressure drop of the refrigerant before the second evaporator, and a condenser arranged downstream the compressor between the compressor and the first and second expansion valves, the circuit having a main circuit, a first subcircuit for the first evaporator and a second subcircuit for the second evaporator, characterized by controlling a total opening of the first expansion valve and the second expansion valve, based on a temperature (T m) and a pressure (p m) of the refrigerant which refrigerant temperature and refrigerant pressure are measured downstream the first and second evaporators at a position between the first and second evaporators and the compressor in the main circuit, the measuring position being situated between a point, where the first subcircuit and the second subcircuit merge into the main circuit 6, and an inlet of the compressor.
Device for cardiopulmonary massaging and/or resuscitation, having a massaging device which has a pressing stamp, reversably movable in an operating direction, able to be operated by a drive and able to be positioned on the rib cage of a patient on a target contact region, wherein the pressing stamp can be fixed on the rib cage of the patient on the target contact region and at least during a rest-state between two massage strokes is mounted freely movably in a plane perpendicular to the operating direction, characterised in that the pressing stamp is fixed or can be fixed on a holding means which can be fastened on the rib cage of the patient, wherein the holding means is formed as a holding pad which can be adhesively bonded by means of an adhesive layer on the rib cage.
A method for folding light incontinence pads having a substantially rectangular shape elongate according to a longitudinal axis and comprising a central absorbent pad and an outer edge, the method comprising a step of folding, about a first fold line transversal to the axis, of a first end portion of the incontinence pad on a central portion, a second step of folding, about a second fold line transversal to the axis, of a second end portion of the incontinence pad on the first end portion; method being characterised in that it comprises a step of folding elasticated segments of the edge located between the first and second fold lines (11, 12) on the central portion; the step of folding the elasticated segments of the edge being between a first sub-step of partly folding the first portion and a second sub-step of completely folding the first portion on the central portion.
A communication unit configured to communicate according to a protocol in which unit addresses are not of a predetermined length, the communication unit configured to: send a discovery request to a discoverable unit; receive a discovery response from the discoverable unit, the discovery response comprising an address field of length unknown to the communication unit, the discovery response further comprising a flag following the address field, wherein the address field is populated with bits all having a first bit value, the flag having a second bit value different to the first bit value; and determine the address field length by counting the number of bits prior to the flag. send a discovery request to a discoverable unit; receive a discovery response from the discoverable unit, the discovery response comprising an address field of length unknown to the communication unit, the discovery response further comprising a flag following the address field, wherein the address field is populated with bits all having a first bit value, the flag having a second bit value different to the first bit value; and determine the address field length by counting the number of bits prior to the flag.
Manufacturing system for additively manufacturing a workpiece, comprising: - a building platform, - a lifting device for the building platform, - a squeegee device, - an optical device, and - a control unit, wherein the squeegee device is located in a building chamber of the manufacturing system, wherein the squeegee device comprises at least one coating element for applying a powder material to the building platform, wherein the squeegee device comprises a squeegee revolver with a cylindrical body, the circumferential surface of which has at least one receptacle into which the coating element is inserted, and another receptacle into which a cleaning element for removing powder residues from a bottom of the building chamber, an interface between the bottom of the building chamber and a powder container, a powder overflow container and/or a building container is inserted, wherein the squeegee revolver is rotatable so that it can be switched to the cleaning element by rotation, so that the cleaning element is facing the bottom of the building chamber, the interface between the bottom of the building chamber and the powder container, the powder overflow container and/or the building container in order to remove the powder residues, wherein the optical device comprises an optical element for recording image data of the building platform and/or of the powder layer, wherein the lifting device is designed for raising and/or lowering the building platform, and wherein the control unit is designed to control the lifting device and the squeegee device on the basis of the image data. - a building platform, - a lifting device for the building platform, - a squeegee device, - an optical device, and - a control unit, wherein the squeegee device is located in a building chamber of the manufacturing system, wherein the squeegee device comprises at least one coating element for applying a powder material to the building platform, wherein the squeegee device comprises a squeegee revolver with a cylindrical body, the circumferential surface of which has at least one receptacle into which the coating element is inserted, and another receptacle into which a cleaning element for removing powder residues from a bottom of the building chamber, an interface between the bottom of the building chamber and a powder container, a powder overflow container and/or a building container is inserted, wherein the squeegee revolver is rotatable so that it can be switched to the cleaning element by rotation, so that the cleaning element is facing the bottom of the building chamber, the interface between the bottom of the building chamber and the powder container, the powder overflow container and/or the building container in order to remove the powder residues, wherein the optical device comprises an optical element for recording image data of the building platform and/or of the powder layer, wherein the lifting device is designed for raising and/or lowering the building platform, and wherein the control unit is designed to control the lifting device and the squeegee device on the basis of the image data.
An artificial turf filament comprising a polyethylene wherein the polyethylene has a density of 0.910-0.940 g/cm 3 and a melt index of 0.5-5 g/10 min as measured in accordance with ASTM D1238 (190°C and 2.16 kg), wherein the filament has a surface area, with at least a portion of the surface area being exposed to a composition containing at least 5 wt% of a halogen to form a halogenated surface.
A friction stir welding apparatus for overlapped joints, comprising a rotor having a shoulder and a probe that is provided so as to protrude from the shoulder of the rotor and so as to be disposed concentrically with a center axis of the rotor, wherein a helical groove is formed in the peripheral surface of the probe, from a tip of the probe toward the shoulder, the depth of the groove being formed so as to gradually decrease from the tip of the probe toward the shoulder, characterized in that a channel-shaped groove is provided in a peripheral surface of the probe that extends from the tip of the probe along the direction of the center axis of the probe, and wherein the cross-section, which is perpendicular to the center axis of the probe, of the channel-shaped groove is formed to have the shape of an arc.
A system for controlling garden equipment by operating a garden equipment control device, the system comprising: a first module configured to pair with the garden equipment control device over a first network, where the first module is configured to control the garden equipment control device when paired therewith; a second module configured to wirelessly communicate with the garden equipment control device over a second network, wherein the second module is connected to the garden equipment control device through a gateway; and a controller associated with the garden equipment control device, wherein the controller is configured to check whether the garden equipment control device is paired with the gateway; wherein when the controller determines that the garden equipment control device is paired with the gateway: the second module is enabled to control the garden equipment control device, and the first module is disabled to control the garden equipment control device. a first module configured to pair with the garden equipment control device over a first network, where the first module is configured to control the garden equipment control device when paired therewith; a second module configured to wirelessly communicate with the garden equipment control device over a second network, wherein the second module is connected to the garden equipment control device through a gateway; and a controller associated with the garden equipment control device, wherein the controller is configured to check whether the garden equipment control device is paired with the gateway; wherein when the controller determines that the garden equipment control device is paired with the gateway: the second module is enabled to control the garden equipment control device, and the first module is disabled to control the garden equipment control device. the second module is enabled to control the garden equipment control device, and the first module is disabled to control the garden equipment control device.
A straddle vehicle comprising: a first frame located in front of a head pipe and supported by the head pipe; a hanging frame connected to the first frame and including a plurality of extension portions extending downward from the first frame and an attachment portion connecting at least two of the plurality of extension portions to each other; a front cowl arranged at a front part of the straddle vehicle and protruding forward, a recess being formed at a rear side of the front cowl; a radar device supported by the attachment portion of the hanging frame and arranged in the recess of the front cowl; a connection member connecting a lower wall inside the recess of the front cowl and the hanging frame; and a radar stay connected to the attachment portion so as to protrude forward from the attachment portion of the hanging frame, the radar device attached to the radar stay, and the radar device is attached to the radar stay so that the radar device does not contact with a lower wall in the recess of the front cowl, characterised in that the radar device includes an orientation adjustment mechanism adjusting orientation of the radar device. a first frame located in front of a head pipe and supported by the head pipe; a hanging frame connected to the first frame and including a plurality of extension portions extending downward from the first frame and an attachment portion connecting at least two of the plurality of extension portions to each other; a front cowl arranged at a front part of the straddle vehicle and protruding forward, a recess being formed at a rear side of the front cowl; a radar device supported by the attachment portion of the hanging frame and arranged in the recess of the front cowl; a connection member connecting a lower wall inside the recess of the front cowl and the hanging frame; and a radar stay connected to the attachment portion so as to protrude forward from the attachment portion of the hanging frame, the radar device attached to the radar stay, and the radar device is attached to the radar stay so that the radar device does not contact with a lower wall in the recess of the front cowl, characterised in that the radar device includes an orientation adjustment mechanism adjusting orientation of the radar device.