mhurhangee/ep-ind-claims huggingface dataset:
An inhibitor of TUTase Zcchc11 or Zcchc6, which is an antibody or an aptamer, for use in: (a) a method of treating a Lin28A-expressing cancer in a subject in need thereof, comprising administering a therapeutically effective amount of said inhibitor of said TUTase and a pharmaceutically acceptable carrier, whereby the growth of the Lin28A-expressing cancer is reduced in the presence of the inhibitor; or (b) a method of treatment of cancer in a subject in need thereof, the method comprising measuring the level of expression of Lin28A in a cancerous tissue obtained from the subject; and administering a therapeutically effective amount of said inhibitor of said TUTase to the subject when the cancerous tissue is positive for Lin28A expression. (a) a method of treating a Lin28A-expressing cancer in a subject in need thereof, comprising administering a therapeutically effective amount of said inhibitor of said TUTase and a pharmaceutically acceptable carrier, whereby the growth of the Lin28A-expressing cancer is reduced in the presence of the inhibitor; or (b) a method of treatment of cancer in a subject in need thereof, the method comprising measuring the level of expression of Lin28A in a cancerous tissue obtained from the subject; and administering a therapeutically effective amount of said inhibitor of said TUTase to the subject when the cancerous tissue is positive for Lin28A expression.
A method performed by a sidelink transmitting user equipment, SL TX UE, for sidelink, SL, vehicle to everything, V2X, unicast transmission to a sidelink receiving user equipment, SL RX UE, the method comprising: receiving, by the SL TX UE, a Radio Resource Control, RRC, configuration from a base station, the RRC configuration including at least information for enabling SL Channel State Information, CSI, reporting and first Modulation and Coding Scheme, MCS, information for SL transmission by the SL TX UE; transmitting a CSI-Reference Signal, CSI-RS, measurement resource configuration to the SL RX UE for deriving an SL CSI report; transmitting an aperiodic CSI report trigger to the SL RX UE for triggering the SL CSI report in a sidelink control information, SCI, the SCI including second MCS information for a SL transmission associated with the SCI, the SL transmission including a CSI-RS resource based on the CSI-RS measurement resource configuration; and receiving the SL CSI report from the SL RX UE in a Physical Sidelink Shared Channel, PSSCH, wherein: the SL TX UE is associated with a first identifier, ID, the SL RX UE is associated with a second ID, and the SL CSI report identifies an associated SL connection based on the first ID and the second ID carried in the PSSCH. receiving, by the SL TX UE, a Radio Resource Control, RRC, configuration from a base station, the RRC configuration including at least information for enabling SL Channel State Information, CSI, reporting and first Modulation and Coding Scheme, MCS, information for SL transmission by the SL TX UE; transmitting a CSI-Reference Signal, CSI-RS, measurement resource configuration to the SL RX UE for deriving an SL CSI report; transmitting an aperiodic CSI report trigger to the SL RX UE for triggering the SL CSI report in a sidelink control information, SCI, the SCI including second MCS information for a SL transmission associated with the SCI, the SL transmission including a CSI-RS resource based on the CSI-RS measurement resource configuration; and receiving the SL CSI report from the SL RX UE in a Physical Sidelink Shared Channel, PSSCH, wherein: the SL TX UE is associated with a first identifier, ID, the SL RX UE is associated with a second ID, and the SL CSI report identifies an associated SL connection based on the first ID and the second ID carried in the PSSCH. the SL TX UE is associated with a first identifier, ID, the SL RX UE is associated with a second ID, and the SL CSI report identifies an associated SL connection based on the first ID and the second ID carried in the PSSCH.
A pharmaceutical dosage form which comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric carrier composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer having a molecular weight distribution such that at least 95 % by weight of the homopolymer has a molecular weight within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. a) a vinylpyrrolidone homopolymer having a molecular weight distribution such that at least 95 % by weight of the homopolymer has a molecular weight within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000.
A method for wireless communications by a user equipment, UE, comprising: establishing, via a base station, BS, a secure connection with a network; negotiating, via the secure connection, an encryption mechanism for the UE to use to transmit data without establishing a full radio resource control, RRC connection; entering an idle mode after negotiating the encryption mechanism; using the negotiated encryption mechanism to encrypt data to be transmitted to the network; and transmitting a packet containing the encrypted data to the BS without establishing the full RRC connection, characterised in that: the packet further comprises a mechanism for the network to authenticate the UE, and the mechanism comprises at least one of a medium access control, MAC or short MAC address. establishing, via a base station, BS, a secure connection with a network; negotiating, via the secure connection, an encryption mechanism for the UE to use to transmit data without establishing a full radio resource control, RRC connection; entering an idle mode after negotiating the encryption mechanism; using the negotiated encryption mechanism to encrypt data to be transmitted to the network; and transmitting a packet containing the encrypted data to the BS without establishing the full RRC connection, characterised in that: the packet further comprises a mechanism for the network to authenticate the UE, and the mechanism comprises at least one of a medium access control, MAC or short MAC address.
A smoking article comprising: a tobacco rod; and a wrapper disposed about the tobacco rod, the wrapper comprising a plurality of aggregated particles, each aggregated particle comprising particles of functional material, a whitener, and a polymeric binder, wherein each aggregated particle has an inner core comprising at least some of the particles of functional material, and wherein at least some of the whitener is distributed on the outer surface of the inner core, and wherein the polymeric binder binds the components of each aggregated particle together.
A method for centralized address resolution in a data center comprising at least one processing resource, at least one processing resource controller, at least one networking resource, and at least one networking resource software-defined network controller; this method comprising the steps of: - maintaining a local address resolution database associated to a processing resource controller, for storing all the MAC address - IP address associations of the processing resources controlled by this controller; - maintaining a local address resolution database associated to a networking resource software-defined network controller, for storing all the MAC address - IP address associations of the networking resources controlled by this controller; - maintaining a centralized address resolution database (CARDB) for storing all the MAC address - IP address associations within the data center; - when a resource requests the resolution of an IP address, sending a unicast read message from this resource to its controller, this controller checking whether the associated local database (LDB1, LDB2) stores a MAC address associated to this IP address, and: -- if a MAC address, associated to this IP address, is stored in this local database, then supplying the MAC address to the resource that requested the resolution of this IP address; -- if no MAC address, associated to this IP address, is stored in this local database, then forwarding the unicast read message to the centralized address resolution database (CARDB). - maintaining a local address resolution database associated to a processing resource controller, for storing all the MAC address - IP address associations of the processing resources controlled by this controller; - maintaining a local address resolution database associated to a networking resource software-defined network controller, for storing all the MAC address - IP address associations of the networking resources controlled by this controller; - maintaining a centralized address resolution database (CARDB) for storing all the MAC address - IP address associations within the data center; - when a resource requests the resolution of an IP address, sending a unicast read message from this resource to its controller, this controller checking whether the associated local database (LDB1, LDB2) stores a MAC address associated to this IP address, and: -- if a MAC address, associated to this IP address, is stored in this local database, then supplying the MAC address to the resource that requested the resolution of this IP address; -- if no MAC address, associated to this IP address, is stored in this local database, then forwarding the unicast read message to the centralized address resolution database (CARDB). -- if a MAC address, associated to this IP address, is stored in this local database, then supplying the MAC address to the resource that requested the resolution of this IP address; -- if no MAC address, associated to this IP address, is stored in this local database, then forwarding the unicast read message to the centralized address resolution database (CARDB).
A fault detection system, comprising: a sensor configured to output a signal indicative of a vibration within a component of a vehicle in operation; and a tachometer configured to output a signal indicative of a speed associated to the component; and a controller configured to: log vibration data corresponding to the signal received from the sensor; acquire the speed signal indicative of a speed associated with the component; log speed data based on the speed signal together with the vibration data; analyze the speed data to detect a stable speed state; select a portion of the vibration data corresponding to the stable speed state; generate a first prediction of a health condition of the component with a first model based on the selected portion of the vibration data; generate a second prediction of the health condition of the component with a second model based on the selected portion of the vibration data; and output the health condition of the component based on the first prediction and the second prediction. a sensor configured to output a signal indicative of a vibration within a component of a vehicle in operation; and a tachometer configured to output a signal indicative of a speed associated to the component; and a controller configured to: log vibration data corresponding to the signal received from the sensor; acquire the speed signal indicative of a speed associated with the component; log speed data based on the speed signal together with the vibration data; analyze the speed data to detect a stable speed state; select a portion of the vibration data corresponding to the stable speed state; generate a first prediction of a health condition of the component with a first model based on the selected portion of the vibration data; generate a second prediction of the health condition of the component with a second model based on the selected portion of the vibration data; and output the health condition of the component based on the first prediction and the second prediction. log vibration data corresponding to the signal received from the sensor; acquire the speed signal indicative of a speed associated with the component; log speed data based on the speed signal together with the vibration data; analyze the speed data to detect a stable speed state; select a portion of the vibration data corresponding to the stable speed state; generate a first prediction of a health condition of the component with a first model based on the selected portion of the vibration data; generate a second prediction of the health condition of the component with a second model based on the selected portion of the vibration data; and output the health condition of the component based on the first prediction and the second prediction.
An ultraviolet ray curable ink composition adapted to be ejected by using an ink jet method, comprising: a polymerizable compound; metal powder; and a polyether based solvent; wherein the metal powder is constituted from metal particles subjected to a surface treatment with a fluorine type silane compound and/or a fluorine type phosphoric acid ester as a surface treatment agent, and wherein an amount of the polyether based solvent contained in the ultraviolet ray curable ink composition is in the range of 0.05 mass% or more but 7.0 mass% or less. a polymerizable compound; metal powder; and a polyether based solvent; wherein the metal powder is constituted from metal particles subjected to a surface treatment with a fluorine type silane compound and/or a fluorine type phosphoric acid ester as a surface treatment agent, and wherein an amount of the polyether based solvent contained in the ultraviolet ray curable ink composition is in the range of 0.05 mass% or more but 7.0 mass% or less.
A method for producing a transition metal-isocyanide complex represented by formula below, the method comprising reacting together a compound containing a transition metal selected from V, Cr, Mo, W, Fe, Ru, Co, Rh, Ni, Pd, and Pt, and an isocyanide compound represented by formula below in the presence of an alkali metal supported by a solid substance insoluble in an organic solvent, x -R 1 wherein R 1 represents a monovalent to trivalent organic group that has 1 to 30 carbon atoms, is optionally substituted with a halogen atom, and in which one or more atoms selected from oxygen, nitrogen, sulfur, and silicon are optionally interposed, and x represents an integer of 1 to 3, M 1 a b wherein M 1 represents V, Cr, Mo, W, Fe, Ru, Co, Rh, Ni, Pd, or Pt with an oxidation number of zero, L represents an isocyanide compound represented by the formula, M 1 may be the same or different, L may be the same or different, "a" represents an integer of 1 to 8, and "b" represents an integer of 2 to 12, wherein the solid substance insoluble in an organic solvent is at least one selected from carbon materials, silicon compounds, metal oxides and polymer compounds.
A method for navigating a robot for docking with a robot charger docking station, comprising: receiving an initial pose associated with a robot charger docking station; receiving a mating pose associated with the robot charger docking station; performing a first navigation of a robot from a location to the initial pose; and performing a second navigation of the robot from the initial pose to the mating pose, wherein the second navigation proceeds substantially along an arc path from the initial pose to the mating pose, thereby causing the electrical charging port of the robot to mate with an electrical charging assembly of the robot charger docking station; wherein the arc path from the initial pose to the mating pose comprises a section of a unique circle having radius r and center X C, Y C equidistant from a first location X R, Y R associated with the initial pose and a second location X D, Y D associated with the mating pose, characterised in that an instantaneous linear velocity x ' R and an instantaneous angular velocity θ' R of the robot, at a pose along the arc path, are maintained in substantially constant relation with radius r: θ R ′ = x R ′ r and wherein controlling a rotational error of the robot comprises issuing a proportional control according to: θ R ′ = kφ where k is a proportional control constant and Φ is a rotational error, and/or a weighted control according to θ R ′ = α kφ + β x R ′ r where α and β are weighting parameters. receiving an initial pose associated with a robot charger docking station; receiving a mating pose associated with the robot charger docking station; performing a first navigation of a robot from a location to the initial pose; and performing a second navigation of the robot from the initial pose to the mating pose, wherein the second navigation proceeds substantially along an arc path from the initial pose to the mating pose, thereby causing the electrical charging port of the robot to mate with an electrical charging assembly of the robot charger docking station; wherein the arc path from the initial pose to the mating pose comprises a section of a unique circle having radius r and center X C, Y C equidistant from a first location X R, Y R associated with the initial pose and a second location X D, Y D associated with the mating pose, characterised in that an instantaneous linear velocity x ' R and an instantaneous angular velocity θ' R of the robot, at a pose along the arc path, are maintained in substantially constant relation with radius r: θ R ′ = x R ′ r and wherein controlling a rotational error of the robot comprises issuing a proportional control according to: θ R ′ = kφ where k is a proportional control constant and Φ is a rotational error, and/or a weighted control according to θ R ′ = α kφ + β x R ′ r where α and β are weighting parameters.
A door opening mechanism for a domestic appliance, the domestic appliance including a housing, a front door, and a resilient member, for urging the door open, wherein the door opening mechanism is adapted to be located within the housing; the door opening mechanism comprising: a rotary motor, for driving a member in response to control signals; characterised by further comprising a retention mechanism (308-314, 320-334), engageable with the door and movable between a first configuration (Fig. 3(b)), in which the door is retained, or capable of being retained, in a closed position, and a second configuration (Fig, 3(d)), in which the door is non-engaged; and a cam, the cam having a plurality of cam surfaces, each cam surface being adapted to move the retention mechanism out of said first configuration through camming action, the cam being the member driven, in use, by the rotary motor. a rotary motor, for driving a member in response to control signals; characterised by further comprising a retention mechanism (308-314, 320-334), engageable with the door and movable between a first configuration (Fig. 3(b)), in which the door is retained, or capable of being retained, in a closed position, and a second configuration (Fig, 3(d)), in which the door is non-engaged; and a cam, the cam having a plurality of cam surfaces, each cam surface being adapted to move the retention mechanism out of said first configuration through camming action, the cam being the member driven, in use, by the rotary motor.
A tissue retaining device comprising: a flexible elongated suture thread having a surface (302, 502, 602), a longitudinal axis, a deployment direction along the longitudinal axis and a reverse direction, opposite to the deployment direction along the longitudinal axis; the suture thread having distributed on at least a portion of the surface thereof a plurality of textural features, each of the textural features comprising a top surface approximately parallel to the surface of the suture and having a height of between 500nm and 10μm; and wherein the plurality of textural features includes one or more chevrons; and wherein the plurality of textural features cause the flexible elongated suture thread to have a greater resistance to movement through tissue in the reverse direction than in the deployment direction. a flexible elongated suture thread having a surface (302, 502, 602), a longitudinal axis, a deployment direction along the longitudinal axis and a reverse direction, opposite to the deployment direction along the longitudinal axis; the suture thread having distributed on at least a portion of the surface thereof a plurality of textural features, each of the textural features comprising a top surface approximately parallel to the surface of the suture and having a height of between 500nm and 10μm; and wherein the plurality of textural features includes one or more chevrons; and wherein the plurality of textural features cause the flexible elongated suture thread to have a greater resistance to movement through tissue in the reverse direction than in the deployment direction.
A food processing vat system comprising: a vat defining an inside space therein; a shaft defining a length therefor rotating within the inside space of the vat; a first blade assembly mounted to and extending generally radially from the shaft in a first direction; and a second blade assembly that is arranged adjacent and spaced from the first blade assembly along the length of the shaft, the second blade assembly mounted to and extending generally radially from the shaft in a second, opposite direction, each of the blade assemblies defining a curved basket that includes multiple curved longitudinal knives (115, 118) that extend in a generally radial direction from the shaft, the multiple curved longitudinal knives (115, 118) being spaced from each other along a width of the curved basket, characterized in that it further comprises multiple curved transverse knives (120, 122) that extend along the width of the curved basket and interconnect the multiple curved longitudinal knives (115, 118) of the curved basket; wherein each of the multiple curved longitudinal knives (115, 118) and the multiple transverse knives (120, 122) having a concave side with an edge that is chisel-sharpened or ground to a sharp and thin edge such that the multiple curved longitudinal knives (115, 118) and the multiple transverse knives (120, 122) of each of the blade assemblies cumulatively define a concave cutting surface of the respective blade assembly, the opposing edges of said knives being flat. a vat defining an inside space therein; a shaft defining a length therefor rotating within the inside space of the vat; a first blade assembly mounted to and extending generally radially from the shaft in a first direction; and a second blade assembly that is arranged adjacent and spaced from the first blade assembly along the length of the shaft, the second blade assembly mounted to and extending generally radially from the shaft in a second, opposite direction, each of the blade assemblies defining a curved basket that includes multiple curved longitudinal knives (115, 118) that extend in a generally radial direction from the shaft, the multiple curved longitudinal knives (115, 118) being spaced from each other along a width of the curved basket, characterized in that it further comprises multiple curved transverse knives (120, 122) that extend along the width of the curved basket and interconnect the multiple curved longitudinal knives (115, 118) of the curved basket; wherein each of the multiple curved longitudinal knives (115, 118) and the multiple transverse knives (120, 122) having a concave side with an edge that is chisel-sharpened or ground to a sharp and thin edge such that the multiple curved longitudinal knives (115, 118) and the multiple transverse knives (120, 122) of each of the blade assemblies cumulatively define a concave cutting surface of the respective blade assembly, the opposing edges of said knives being flat.