A compound of formula wherein the ring designated A can further comprise an additional nitrogen atom in any position that bears any of W, X, Y, or Z, provided that the respective group W, X, Y, or Z is absent from that position; W is H, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, or halo; X is H, halo, nitro, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; Y is H, halo, (C1-C6)alkyl, or (C3-C9)cycloalkyl; Z is halo, hydroxy, CO 2 R, C(=O)NR 2, CN, heteroaryl(C 0 -C 6)alkyl, hydroxy(C1-C6)alkyl, HC(=O), (C1-C6)C(=O), or CR(=NOR); wherein each independently selected R is H, (C1-C6)alkyl, (C3-C9)cycloalkyl, (C6-C10)aryl, or (C6-C10)aryl(C1-C6)alkyl; or, any adjacent pair of W, X, and Y, can together with the atoms to which they are bonded form a fused cycloalkyl, heterocyclyl, or aryl, or heteroaryl, any of which can be mono- or independently multi-substituted with (C1-C6)alkyl, (C3-C9)cycloalkyl, halo, nitro, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; wherein any alkyl, cycloalkyl, aryl, or heteroaryl of W, X, Y, or Z, can be unsubstituted or can be mono- or independently multi-substituted with (C1-C6)alkyl, (C3-C9)cycloalkyl, halo, nitro, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; the ring system Cyc is any one of wherein R 1 and, optionally, (R 2) m, are bonded thereto at any position, and wherein a wavy line indicates a point of bonding; R 1 is (CH 2) n NR a R b, wherein R a and R b are each independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heterocyclylalkyl, wherein any alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heterocyclylalkyl, is substituted with 0, 1, 2, 3, or 4 independently selected J, and wherein any heterocyclyl or cycloalkyl is mono-, bi-, or tri-cyclic, wherein n = 0, 1, or 2; R 2 is (C1-C6)alkyl, hydroxy(C1-C6)alkyl, OR, CO 2 R, or halo, wherein m = 0, 1, or 2; J is independently at each occurrence OR, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, CO 2 R, or halo; or any pharmaceutically acceptable salt thereof; with the proviso that the compound of Formula is not one of the following compounds: the ring designated A can further comprise an additional nitrogen atom in any position that bears any of W, X, Y, or Z, provided that the respective group W, X, Y, or Z is absent from that position; W is H, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, or halo; X is H, halo, nitro, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; Y is H, halo, (C1-C6)alkyl, or (C3-C9)cycloalkyl; Z is halo, hydroxy, CO 2 R, C(=O)NR 2, CN, heteroaryl(C 0 -C 6)alkyl, hydroxy(C1-C6)alkyl, HC(=O), (C1-C6)C(=O), or CR(=NOR); wherein each independently selected R is H, (C1-C6)alkyl, (C3-C9)cycloalkyl, (C6-C10)aryl, or (C6-C10)aryl(C1-C6)alkyl; or, any adjacent pair of W, X, and Y, can together with the atoms to which they are bonded form a fused cycloalkyl, heterocyclyl, or aryl, or heteroaryl, any of which can be mono- or independently multi-substituted with (C1-C6)alkyl, (C3-C9)cycloalkyl, halo, nitro, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; wherein any alkyl, cycloalkyl, aryl, or heteroaryl of W, X, Y, or Z, can be unsubstituted or can be mono- or independently multi-substituted with (C1-C6)alkyl, (C3-C9)cycloalkyl, halo, nitro, NR a R b, N(R a)C(=O)(C1-C6)alkyl, CO 2 R, or heteroaryl; the ring system Cyc is any one of wherein R 1 and, optionally, (R 2) m, are bonded thereto at any position, and wherein a wavy line indicates a point of bonding; R 1 is (CH 2) n NR a R b, wherein R a and R b are each independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heterocyclylalkyl, wherein any alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heterocyclylalkyl, is substituted with 0, 1, 2, 3, or 4 independently selected J, and wherein any heterocyclyl or cycloalkyl is mono-, bi-, or tri-cyclic, wherein n = 0, 1, or 2; R 2 is (C1-C6)alkyl, hydroxy(C1-C6)alkyl, OR, CO 2 R, or halo, wherein m = 0, 1, or 2; J is independently at each occurrence OR, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C3-C9)cycloalkyl, CO 2 R, or halo; or any pharmaceutically acceptable salt thereof;