A compound having structural Formula I: or the pharmaceutically acceptable salts thereof wherein: represents a heterocyclic ring selected from the group consisting of: Z 1 is selected from the group consisting of: Z 2 is selected from the group consisting of: X is selected from the group consisting of -H, -OH, -OC 1-3 alkyl, -F, oxo, NH 2, and -CH 3; Y is selected from the group consisting of -H, -OH, -OC 1-3 alkyl, -F, oxo, NH 2, and -CH 3; X 1 and Y 1 are each independently selected from the group consisting of -H and -CH 3; X2 and Y 2 are each -O-; provided that when X is oxo then X 1 is absent and when Y is oxo then Y 1 is absent; and further provided that when neither X 2 nor Y 2 is present, then at least one of X and Y is selected from the group consisting of -OH, -OC 1-3 alkyl, -F and oxo; R 1 and R 2 are each independently selected from the group consisting of -H, -halo, -C 3 -C 6 cycloalkyl, -OR 8, -SR 8, -SOR 8, -SO 2 R 8, -(CH 2) n OR 8 and C 1 -C 6 alkyl optionally substituted with 1-3 of -F; one of R 3a and R 3b is selected from the group consisting of -CN and -NO 2 and the other is R e; one of R 4a and R 4b is selected from the group consisting of -CN and -NO 2 and the other is R f; R5 and R 6 are each independently selected from the group consisting of -H, -C 1-6 alkyl, -C 3-6 cycloalkyl, -CF 3, -CHF 2, -CH 2 F and -CH 2 OH; R7 is selected from the group consisting of -H, -CH 3, -CF 3, -CHF 2, -CH 2 F and -CH 2 OH; Ra and R b are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; R c and R d are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; R e and R f are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; n is an integer selected from 1, 2 and 3; and R 8 is independently selected at each occurrence from the group consisting of -H, -C 3-6 cycloalkyl and -C 1-6 alkyl optionally substituted with 1-3 of -F. Z 1 is selected from the group consisting of: Z 2 is selected from the group consisting of: X is selected from the group consisting of -H, -OH, -OC 1-3 alkyl, -F, oxo, NH 2, and -CH 3; Y is selected from the group consisting of -H, -OH, -OC 1-3 alkyl, -F, oxo, NH 2, and -CH 3; X 1 and Y 1 are each independently selected from the group consisting of -H and -CH 3; X2 and Y 2 are each -O-; provided that when X is oxo then X 1 is absent and when Y is oxo then Y 1 is absent; and further provided that when neither X 2 nor Y 2 is present, then at least one of X and Y is selected from the group consisting of -OH, -OC 1-3 alkyl, -F and oxo; R 1 and R 2 are each independently selected from the group consisting of -H, -halo, -C 3 -C 6 cycloalkyl, -OR 8, -SR 8, -SOR 8, -SO 2 R 8, -(CH 2) n OR 8 and C 1 -C 6 alkyl optionally substituted with 1-3 of -F; one of R 3a and R 3b is selected from the group consisting of -CN and -NO 2 and the other is R e; one of R 4a and R 4b is selected from the group consisting of -CN and -NO 2 and the other is R f; R5 and R 6 are each independently selected from the group consisting of -H, -C 1-6 alkyl, -C 3-6 cycloalkyl, -CF 3, -CHF 2, -CH 2 F and -CH 2 OH; R7 is selected from the group consisting of -H, -CH 3, -CF 3, -CHF 2, -CH 2 F and -CH 2 OH; Ra and R b are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; R c and R d are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; R e and R f are each independently selected from the group consisting of (a) -H, (b) halo, (c) -C 1-6 alkyl optionally substituted with 1-3 of -F, (d) -C 3-6 cycloalkyl, (e) -OC 1-3 alkyl optionally substituted with 1-3 of -F, (f) -OR 8, (g) -CO 2 C 1-6 alkyl optionally substituted with 1-3 of -F, (h) -(CH 2) n OR 8, (i) -SR 8, (j) -SOR 8, (k) -SO 2 R 8, -NHCOR 8 and (m) -NHSO 2 R 8; n is an integer selected from 1, 2 and 3; and R 8 is independently selected at each occurrence from the group consisting of -H, -C 3-6 cycloalkyl and -C 1-6 alkyl optionally substituted with 1-3 of -F.