A method of manufacturing a bone grafting substitute having a hole, the method comprising: a biodegradable polymer preparation operation of preparing biodegradable polymer; a molding material preparation operation of preparing a molding material by mixing the biodegradable polymer with a bone material; a molding material injection operation of injecting the molding material into a hole forming mold for molding a bone grafting substitute having a hole; and a bone grafting substitute having a hole molding operation of drying the molding material injected into the hole forming mold at a predetermined temperature, characterized in that the hole forming mold comprises: an upper mold provided to mold the bone grafting substitute having a hole and comprising a plurality of bone grafting substitute main body holes that are formed by penetrating the upper mold and arranged apart from each other; and a lower mold provided, when coupled to the upper mold, to allow the plurality of bone grafting substitute main body holes to form a shape of the bone grafting substitute having a hole, and the molding material injection operation comprises: combining the upper mold to the lower mold; and injecting the molding material into the hole forming mold in a state in which the upper mold and the lower mold are combined to each other. a biodegradable polymer preparation operation of preparing biodegradable polymer; a molding material preparation operation of preparing a molding material by mixing the biodegradable polymer with a bone material; a molding material injection operation of injecting the molding material into a hole forming mold for molding a bone grafting substitute having a hole; and a bone grafting substitute having a hole molding operation of drying the molding material injected into the hole forming mold at a predetermined temperature, characterized in that the hole forming mold comprises: an upper mold provided to mold the bone grafting substitute having a hole and comprising a plurality of bone grafting substitute main body holes that are formed by penetrating the upper mold and arranged apart from each other; and a lower mold provided, when coupled to the upper mold, to allow the plurality of bone grafting substitute main body holes to form a shape of the bone grafting substitute having a hole, and the molding material injection operation comprises: combining the upper mold to the lower mold; and injecting the molding material into the hole forming mold in a state in which the upper mold and the lower mold are combined to each other. an upper mold provided to mold the bone grafting substitute having a hole and comprising a plurality of bone grafting substitute main body holes that are formed by penetrating the upper mold and arranged apart from each other; and a lower mold provided, when coupled to the upper mold, to allow the plurality of bone grafting substitute main body holes to form a shape of the bone grafting substitute having a hole, and the molding material injection operation comprises: combining the upper mold to the lower mold; and injecting the molding material into the hole forming mold in a state in which the upper mold and the lower mold are combined to each other. combining the upper mold to the lower mold; and injecting the molding material into the hole forming mold in a state in which the upper mold and the lower mold are combined to each other.