mhurhangee/ep-ind-claims huggingface dataset:
A can annular gas turbine engine having a gas delivery structure for delivering gases from a plurality of combustors to an annular chamber that extends circumferentially and is oriented concentric to a gas turbine engine axis for delivering the gas flow to a first row of blades, a gas flow path formed by a duct arrangement between a respective combustor and the annular chamber for conveying gases in a downstream direction from each combustor to the first row of turbine blades, wherein a combustor arrangement comprises: a combustor having an inner cylinder surrounding a combustion zone of the combustor, the inner cylinder defining a longitudinal axis of the combustor that is oriented in a radially inward and circumferentially angled direction toward the annular chamber; a cone section having an inlet end receiving the gas flow from the inner cylinder, wherein the cone section defines a decreasing flow area in the downstream direction; a flow sleeve surrounding the inner cylinder; an annular space defined between the inner cylinder and the flow sleeve and defining an air flow path having an annular air inlet defined along the inner cylinder radially inward of a junction between the inner cylinder and the cone section; and a plurality of guide vanes located in circumferentially spaced relation to each other in the annular space, spanning between the flow sleeve and the inner cylinder, the guide vanes each having a length dimension defined between a radially inner leading edge and a radially outer trailing edge, wherein the leading edges of the guide vanes are located along the longitudinal axis radially inward from the junction between the inner cylinder and the cone section. a combustor having an inner cylinder surrounding a combustion zone of the combustor, the inner cylinder defining a longitudinal axis of the combustor that is oriented in a radially inward and circumferentially angled direction toward the annular chamber; a cone section having an inlet end receiving the gas flow from the inner cylinder, wherein the cone section defines a decreasing flow area in the downstream direction; a flow sleeve surrounding the inner cylinder; an annular space defined between the inner cylinder and the flow sleeve and defining an air flow path having an annular air inlet defined along the inner cylinder radially inward of a junction between the inner cylinder and the cone section; and a plurality of guide vanes located in circumferentially spaced relation to each other in the annular space, spanning between the flow sleeve and the inner cylinder, the guide vanes each having a length dimension defined between a radially inner leading edge and a radially outer trailing edge, wherein the leading edges of the guide vanes are located along the longitudinal axis radially inward from the junction between the inner cylinder and the cone section.
A medical device comprising: a substrate material; a polymeric covering material attached to at least a portion of a surface of said substrate material, a plurality of biologically active entities having heparin cofactor II binding activity covalently attached to at least a portion of said polymeric covering material, said plurality of biologically active entities comprising dermatan disulfate; and a biologically compatible organic composition comprising a glycosaminoglycan, dextran, dextran sulfate, polyethylene glycol or glycerol, wherein the biologically compatible organic composition is non-covalently combined with said biologically active entities and polymeric covering material; wherein said biologically active entities have a heparin cofactor II binding activity of at least 5 picomoles heparin cofactor II per square centimeter (pmol/cm 2). a substrate material; a polymeric covering material attached to at least a portion of a surface of said substrate material, a plurality of biologically active entities having heparin cofactor II binding activity covalently attached to at least a portion of said polymeric covering material, said plurality of biologically active entities comprising dermatan disulfate; and a biologically compatible organic composition comprising a glycosaminoglycan, dextran, dextran sulfate, polyethylene glycol or glycerol, wherein the biologically compatible organic composition is non-covalently combined with said biologically active entities and polymeric covering material;
Conjugate comprising linked interleukin 12 (IL-12) subunits p40 and p35 and a single chain diabody, wherein the single chain diabody binds fibronectin domain ED-B.
A cleaning tool for cleaning an area located inside a restriction in a pipe comprising a tool housing with a leading end portion and a mechanical cleaning body arranged on an attachment which, by means of mechanical contact and relative movement between the cleaning body and the area to be cleaned, is arranged to clean the area in question, characterized in that said attachment is formed with an elongated resilient portion attached to the tool housing, and an opposite end portion, said attachment forms an internal side facing a longitudinal centre axis of the cleaning tool and an opposite external side, said attachment comprises on the internal side an internal first inclined plane and on the external side at the end portion an external second inclined plane; - the mechanical cleaning body being arranged on the external side of the attachment, wherein at least the part of the attachment holding the cleaning body being radially movable between a retracted, passive position and an extended, active position; - the tool housing comprises a third internal inclined plane at the leading end portion of the tool housing, said third internal inclined plane facing the longitudinal centre axis; - a pushrod connected to a cone which abuts against the first inclined plane; and - the external second inclined plane is arranged to cooperate with the third internal inclined plane, wherein an axial displacement of the cone from an initial, passive position in a direction of the leading end portion of the tool housing to an active position brings the attachment with the cleaning body to be moved radially outwards, and an axial displacement of the attachment in the direction of the leading end portion of the tool housing brings about an inward radial displacement of the cleaning body by moving the second inclined plane against the third inclined plane. - the mechanical cleaning body being arranged on the external side of the attachment, wherein at least the part of the attachment holding the cleaning body being radially movable between a retracted, passive position and an extended, active position; - the tool housing comprises a third internal inclined plane at the leading end portion of the tool housing, said third internal inclined plane facing the longitudinal centre axis; - a pushrod connected to a cone which abuts against the first inclined plane; and - the external second inclined plane is arranged to cooperate with the third internal inclined plane,
Pigmented aqueous basecoat material comprising a polyether-based reaction product which is preparable by reaction of (a) at least one diisocyanate of the formula OCN - Y - NCO in which Y is a divalent aliphatic, aromatic or araliphatic hydrocarbon radical having 6 to 30 carbon atoms with (b) at least one polyether of the general structural formula in which R is a C 3 to C 6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 200 to 4000 g/mol, where components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses a number-average molecular weight of 500 to 15 000 g/mol and an isocyanate content of less than 0.2%, where the number-average molecular weight is determined as specified in the description. (a) at least one diisocyanate of the formula OCN - Y - NCO in which Y is a divalent aliphatic, aromatic or araliphatic hydrocarbon radical having 6 to 30 carbon atoms with (b) at least one polyether of the general structural formula in which R is a C 3 to C 6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 200 to 4000 g/mol, where components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses a number-average molecular weight of 500 to 15 000 g/mol and an isocyanate content of less than 0.2%, where the number-average molecular weight is determined as specified in the description. R is a C 3 to C 6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 200 to 4000 g/mol, where components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses a number-average molecular weight of 500 to 15 000 g/mol and an isocyanate content of less than 0.2%, where the number-average molecular weight is determined as specified in the description.
A submerged combustion glass manufacturing system comprising: a melter comprising a floor, a roof, a wall structure connecting the floor and roof; one or more submerged combustion burners mounted in the floor, roof and/or wall structure, the submerged combustion burners configured to discharge combustion products including water vapor under a level of material being melted in the melter and create turbulent conditions in substantially all of the material; one or more of the floor, roof, and wall structure comprising fluid-cooled refractory material and an optional metallic external shell, the fluid-cooled refractory material comprising one or more coolant passages; and one or more drain conduits configured to drain at least some water condensed from the water vapor from one or more regions of refractory material substantially saturated with the water away from the melter. a melter comprising a floor, a roof, a wall structure connecting the floor and roof; one or more submerged combustion burners mounted in the floor, roof and/or wall structure, the submerged combustion burners configured to discharge combustion products including water vapor under a level of material being melted in the melter and create turbulent conditions in substantially all of the material; one or more of the floor, roof, and wall structure comprising fluid-cooled refractory material and an optional metallic external shell, the fluid-cooled refractory material comprising one or more coolant passages; and one or more drain conduits configured to drain at least some water condensed from the water vapor from one or more regions of refractory material substantially saturated with the water away from the melter.
A beverage aseptic filling system for both a carbonated beverage and a non-carbonated beverage, the beverage aseptic filling system comprising: a raw material liquid preparation unit configured to prepare a raw material liquid; a beverage sterilization unit that is connected to the raw material liquid preparation unit and is configured to sterilize a beverage; a beverage filling unit configured to fill a container with the beverage; a switching valve that is a valve manifold and is provided between the beverage sterilization unit and the beverage filling unit; a first aseptic tank for storing the beverage from the beverage sterilization unit that is provided between the beverage sterilization unit and the switching valve; a first filling line that is provided between the switching valve and the beverage filling unit; a second filling line that is connected to the switching valve and has a beverage cooling unit for cooling the beverage and a carbonated beverage production unit for injecting carbon dioxide gas into the beverage disposed therein, and a control unit configured to control the switching valve, wherein the switching valve is configured to supply the beverage to either one of the first filling line and the second filling line selectively as controlled by a control signal from the control unit so as to switch a feeding direction between the first filling line and the second filling line, and wherein the second filling line is configured in a loop, so that a beverage from the second filling line can be sent to the first filling line via the switching valve. a raw material liquid preparation unit configured to prepare a raw material liquid; a beverage sterilization unit that is connected to the raw material liquid preparation unit and is configured to sterilize a beverage; a beverage filling unit configured to fill a container with the beverage; a switching valve that is a valve manifold and is provided between the beverage sterilization unit and the beverage filling unit; a first aseptic tank for storing the beverage from the beverage sterilization unit that is provided between the beverage sterilization unit and the switching valve; a first filling line that is provided between the switching valve and the beverage filling unit; a second filling line that is connected to the switching valve and has a beverage cooling unit for cooling the beverage and a carbonated beverage production unit for injecting carbon dioxide gas into the beverage disposed therein, and a control unit configured to control the switching valve, wherein the switching valve is configured to supply the beverage to either one of the first filling line and the second filling line selectively as controlled by a control signal from the control unit so as to switch a feeding direction between the first filling line and the second filling line, and wherein the second filling line is configured in a loop, so that a beverage from the second filling line can be sent to the first filling line via the switching valve.
A process for preparing a composition comprising encapsulated gas microbubbles, comprising the sequential steps of: i) providing an aqueous heated protein solution of a heat-denaturable protein at a temperature necessary to achieve incipient denaturation, where said temperature is in the range 50-100 °C; ii) heating a gas by using heat from said heated protein solution, wherein the gas is heated to a temperature no less than 20 oC below the temperature of said heated protein solution; iii) mixing the heated gas from step (ii) and the heated protein solution from step (i) to obtain a heated gas/liquid mixture; iv) dispersing the heated gas into the protein solution by subjecting the heated gas/liquid mixture from step (iii) to mechanical shear forces to form a composition of gas microbubbles encapsulated by denatured protein. i) providing an aqueous heated protein solution of a heat-denaturable protein at a temperature necessary to achieve incipient denaturation, where said temperature is in the range 50-100 °C; ii) heating a gas by using heat from said heated protein solution, wherein the gas is heated to a temperature no less than 20 oC below the temperature of said heated protein solution; iii) mixing the heated gas from step (ii) and the heated protein solution from step (i) to obtain a heated gas/liquid mixture; iv) dispersing the heated gas into the protein solution by subjecting the heated gas/liquid mixture from step (iii) to mechanical shear forces to form a composition of gas microbubbles encapsulated by denatured protein.
An expression vector that encodes a CD138-specific chimeric antigen receptor and one or more hypoxia-responsive regulatory elements functionally related thereto.
A compound of formula: wherein: X is CR 1 or N; Y is CH, C or N; R 1 is hydrogen, C 1-6 alkoxy or C 1-6 alkyl; R 2 is hydrogen, C 1-6 alkoxy, halo, -C C 1-6 alkyl, CN, Halo-C 1-6 alkyl or C NR 4 R 5; R 3 is hydrogen or C 1-6 alkoxy; R 4 is hydrogen or C 1-6 alkyl: R 5 is hydrogen or C 1-6 alkyl and m and n are integers each independently selected from 1 and 2; or a pharmaceutically acceptable salt thereof for use in the treatment of vitiligo or prevention of vitiligo in a subject at risk of developing vitiligo. X is CR 1 or N; Y is CH, C or N; R 1 is hydrogen, C 1-6 alkoxy or C 1-6 alkyl; R 2 is hydrogen, C 1-6 alkoxy, halo, -C C 1-6 alkyl, CN, Halo-C 1-6 alkyl or C NR 4 R 5; R 3 is hydrogen or C 1-6 alkoxy; R 4 is hydrogen or C 1-6 alkyl: R 5 is hydrogen or C 1-6 alkyl and m and n are integers each independently selected from 1 and 2; or a pharmaceutically acceptable salt thereof for use in the treatment of vitiligo or prevention of vitiligo in a subject at risk of developing vitiligo.
A sheet conveying apparatus comprising: a plurality of rotary conveying elements (1, 2, 12, 13) operable individually or in combination to convey sheets along a conveying path in at least first and second conveying phases wherein the rotary conveying element or combination of rotary conveying elements (1, 2) used to convey sheets in said first conveying phase is not the same as the rotary conveying element or combination of rotary conveying elements (12, 13) used to convey sheets in said second conveying phase; and conveying correction means operable during said first conveying phase to employ first correction information to correct for conveying errors in that phase, and operable during said second conveying phase to employ second correction information, different from said first correction information, to correct for conveying errors in that phase, wherein the conveying correction means are operable during said first conveying phase to employ said first correction information to correct for conveying errors of at least one rotary conveying element used in that phase, and operable during said second conveying phase to employ said second correction information to correct for conveying errors of at least one rotary conveying element used in that phase and wherein the correction information for at least one said conveying phase comprises correction information of first and second types, the first-type correction information being employable to correct conveying errors of a first type in the phase concerned and the second-type correction information being employable to correct conveying errors of a second type in the phase concerned and wherein the first-type correction information is eccentricity correction information employable to correct conveying errors arising from roller eccentricity and the second-type correction information is outer-diameter correction information employable.to correct conveying errors arising from roller outer-diameter variation. a plurality of rotary conveying elements (1, 2, 12, 13) operable individually or in combination to convey sheets along a conveying path in at least first and second conveying phases wherein the rotary conveying element or combination of rotary conveying elements (1, 2) used to convey sheets in said first conveying phase is not the same as the rotary conveying element or combination of rotary conveying elements (12, 13) used to convey sheets in said second conveying phase; and conveying correction means operable during said first conveying phase to employ first correction information to correct for conveying errors in that phase, and operable during said second conveying phase to employ second correction information, different from said first correction information, to correct for conveying errors in that phase,
An apparatus for continuous annealing of a steel strip comprising: a first heating zone configured to firstly heat a strip; a first cooling zone configured to cool the strip firstly heated in the first heating zone; a second heating and soaking zone configured to secondarily heat and soak the strip cooled or in the first cooling zone a second cooling zone configured to cool the strip heated and soaked in the second heating and soaking zone; and an overaging or constant temperature maintaining zone configured to overage the strip or maintain the strip at a constant temperature in a rear of the second cooling zone; and a final cooling zone configured to cool the strip overaged or maintained at the constant temperature in the overaging or constant temperature maintaining zone, and wherein the first cooling zone comprises at least one gas and steam jet device provided therein to generate negative pressure. a first heating zone configured to firstly heat a strip; a first cooling zone configured to cool the strip firstly heated in the first heating zone; a second heating and soaking zone configured to secondarily heat and soak the strip cooled or in the first cooling zone a second cooling zone configured to cool the strip heated and soaked in the second heating and soaking zone; and an overaging or constant temperature maintaining zone configured to overage the strip or maintain the strip at a constant temperature in a rear of the second cooling zone; and a final cooling zone configured to cool the strip overaged or maintained at the constant temperature in the overaging or constant temperature maintaining zone, and wherein the first cooling zone comprises at least one gas and steam jet device provided therein to generate negative pressure.
Medicament delivery device elongated along a longitudinal axis and having a proximal end and a distal end, said device being intended for use in combination with a disposable container which comprises at least one chamber for a liquid medicament encapsulated in the container by at least one movable plunger (23, 26), said device comprises: - an elongated plunger rod configured to be in contact with the at least one movable plunger (23, 26); - a drive mechanism configured to, when the medicament delivery device is activated, apply a force in a proximal direction via said plunger rod acting on said at least one movable plunger (23, 26); - an elogated housing comprising a proximal housing section and a distal housing section, said proximal housing section being configured to accomodate the container and said distal housing section being configured to accomodate the plunger rod and the driving mechanism; the device being characterized in that said elongated plunger rod comprises an outer periphery in which at least two axially separated recesses and/or cut-out portions (35, 36) are arranged for retaining leaking liquid medicament that may flow along the plunger rod to the drive mechanism, and wherein said axially separated recesses and/or cut-out portions (35, 36) of the plunger rod are arranged at different locations around the outer periphery of the plunger rod. - an elongated plunger rod configured to be in contact with the at least one movable plunger (23, 26); - a drive mechanism configured to, when the medicament delivery device is activated, apply a force in a proximal direction via said plunger rod acting on said at least one movable plunger (23, 26); - an elogated housing comprising a proximal housing section and a distal housing section, said proximal housing section being configured to accomodate the container and said distal housing section being configured to accomodate the plunger rod and the driving mechanism; the device being characterized in that said elongated plunger rod comprises an outer periphery in which at least two axially separated recesses and/or cut-out portions (35, 36) are arranged for retaining leaking liquid medicament that may flow along the plunger rod to the drive mechanism, and wherein said axially separated recesses and/or cut-out portions (35, 36) of the plunger rod are arranged at different locations around the outer periphery of the plunger rod.