An apparatus (100; 200; 800; 900; 1400; 1700; 2620; 2710; 2810) for neuromodulating bladder function, comprising: an elongate delivery member (110; 210; 510; 610; 710; 810; 1410; 1710; 1810; 1910; 2210; 2310; 2410) configured and dimensioned to be inserted into a bladder through a urethra; a therapy delivery element (105; 105'; 205; 205'; 305; 505; 505'; 515; 515'; 615; 715; 720; 805'; 1305; 1405; 1705; 1805; 1905; 2205'; 2305; 2510; 2705) coupled with the delivery member, configured to interface with a tissue in a target region of a bladder wall to provide therapy to the target region; and one or more sensing tips (245; 330; 340; 360; 465; 520; 520'; 640; 1315; 1340; 1420; 1425; 1430; 1725; 1740; 1745; 1915; 2105; 2420; 2520; 2525) electrically and mechanically coupled with the elongate delivery member, the sensing tips being configured to interface with one or more tissue surfaces of at least one of the bladder wall and the urethra, the sensing tips configured to convey one or more electrophysiological signals associated with the tissue surfaces at least one of before, during, and after the therapy; and wherein a given one of the sensing tips comprises: one or more electrodes (330; 415a-c; 420a-f; 490; 1355a-d; 1420; 1615; 1635a,b;1655a-d; 2225; 2230; 2235; 2240; 2245; 2520; 2525; 2555a,b; 2560; 2565a-c) on a tissue-interfacing surface thereof; and characterized by a degradable support structure configured to dissolve in the presence of a liquid; wherein the degradable support structure is arranged relative to the tissue-interfacing surface of the given sensing tip such that the degradable support structure when placed beside the bladder wall and wetted dissolves to cause one or more of the electrodes on the tissue-interfacing surface of the given sensing tip to contact the bladder wall; and a housing (2510; 2550) configured for implantation inside the bladder, the housing comprising one or more microcircuits (330; 340; 655; 2515; 2815a; 2815b), an antenna (2530; 2560) and at least one of the sensing tips, the one or more microcircuits configured: to monitor electrophysiological signals at said at least one sensing tip; to perform signal conditioning of the monitored electrophysiological signals; and to convey the conditioned electrophysiological signals to an external reader (2610; 2830) outside the bladder utilizing the antenna; wherein the housing comprises a coating, the coating comprising a neuromodulating substance in a biodegradable retaining medium, the biodegradable retaining medium configured to provide controlled release of the neuromodulating substance into the tissue in the target region of the bladder wall. an elongate delivery member (110; 210; 510; 610; 710; 810; 1410; 1710; 1810; 1910; 2210; 2310; 2410) configured and dimensioned to be inserted into a bladder through a urethra; a therapy delivery element (105; 105'; 205; 205'; 305; 505; 505'; 515; 515'; 615; 715; 720; 805'; 1305; 1405; 1705; 1805; 1905; 2205'; 2305; 2510; 2705) coupled with the delivery member, configured to interface with a tissue in a target region of a bladder wall to provide therapy to the target region; and one or more sensing tips (245; 330; 340; 360; 465; 520; 520'; 640; 1315; 1340; 1420; 1425; 1430; 1725; 1740; 1745; 1915; 2105; 2420; 2520; 2525) electrically and mechanically coupled with the elongate delivery member, the sensing tips being configured to interface with one or more tissue surfaces of at least one of the bladder wall and the urethra, the sensing tips configured to convey one or more electrophysiological signals associated with the tissue surfaces at least one of before, during, and after the therapy; and wherein a given one of the sensing tips comprises: one or more electrodes (330; 415a-c; 420a-f; 490; 1355a-d; 1420; 1615; 1635a,b;1655a-d; 2225; 2230; 2235; 2240; 2245; 2520; 2525; 2555a,b; 2560; 2565a-c) on a tissue-interfacing surface thereof; and characterized by a degradable support structure configured to dissolve in the presence of a liquid; wherein the degradable support structure is arranged relative to the tissue-interfacing surface of the given sensing tip such that the degradable support structure when placed beside the bladder wall and wetted dissolves to cause one or more of the electrodes on the tissue-interfacing surface of the given sensing tip to contact the bladder wall; and a housing (2510; 2550) configured for implantation inside the bladder, the housing comprising one or more microcircuits (330; 340; 655; 2515; 2815a; 2815b), an antenna (2530; 2560) and at least one of the sensing tips, the one or more microcircuits configured: to monitor electrophysiological signals at said at least one sensing tip; to perform signal conditioning of the monitored electrophysiological signals; and to convey the conditioned electrophysiological signals to an external reader (2610; 2830) outside the bladder utilizing the antenna; to monitor electrophysiological signals at said at least one sensing tip; to perform signal conditioning of the monitored electrophysiological signals; and to convey the conditioned electrophysiological signals to an external reader (2610; 2830) outside the bladder utilizing the antenna; wherein the housing comprises a coating, the coating comprising a neuromodulating substance in a biodegradable retaining medium, the biodegradable retaining medium configured to provide controlled release of the neuromodulating substance into the tissue in the target region of the bladder wall.