mhurhangee/ep-ind-claims huggingface dataset:
A compound represented by following Chemical Formula 1, an optical isomer, a diastereomer or a racemate thereof, or a pharmaceutically acceptable salt thereof: wherein A is oxadiazole, dihydrooxazole, thiazole or thiadiazole, optionally substituted by one or more substituents selected from the group consisting of hydrogen, halogen, C1-C6 straight chain or branched chain alkyl and C1-C6 alcohol, the C1-C6 straight chain or branched alkyl or C1-C6 alcohol group being optionally substituted by hydrogen, halogen or a C1-C6 alkoxy group; B is pyridine, pyrimidine, pyrazine or oxadiazole, optionally substituted by one or more substituents selected from the group consisting of hydrogen, halogen, C1-C6 straight chain or branched chain alkyl, C1-C6 alcohol, C1-C6 alkoxy and oxadiazole groups, the C1-C6 straight chain or branched alkyl, C1-C6 alcohol, C1-C6 alkoxy or oxadiazole group being optionally substituted by hydrogen, halogen, C1-C6 alkyl or C1-C6 alkoxy group; and X is independently F, Cl, Br or I. A is oxadiazole, dihydrooxazole, thiazole or thiadiazole, optionally substituted by one or more substituents selected from the group consisting of hydrogen, halogen, C1-C6 straight chain or branched chain alkyl and C1-C6 alcohol, the C1-C6 straight chain or branched alkyl or C1-C6 alcohol group being optionally substituted by hydrogen, halogen or a C1-C6 alkoxy group; B is pyridine, pyrimidine, pyrazine or oxadiazole, optionally substituted by one or more substituents selected from the group consisting of hydrogen, halogen, C1-C6 straight chain or branched chain alkyl, C1-C6 alcohol, C1-C6 alkoxy and oxadiazole groups, the C1-C6 straight chain or branched alkyl, C1-C6 alcohol, C1-C6 alkoxy or oxadiazole group being optionally substituted by hydrogen, halogen, C1-C6 alkyl or C1-C6 alkoxy group; and X is independently F, Cl, Br or I.
A heat transfer system comprising: a fluid inlet; a fluid outlet; and a substrate in fluid communication with the fluid inlet and fluid outlet, the substrate comprises a heat exchange region having a heat transfer surface and a flow field adjacent the heat transfer surface, the flow field comprises a fluid flow area comprising an open region throughout the flow field, a positive taper of the flow field cross-sectional area in the fluid flow direction, and a heat transfer region in thermal communication with the heat exchange region, wherein the flow field heat transfer region comprises a plurality of open enhancement features from about 1 micron to about 3 mm in height, and the open region being a region of the flow field containing a gap above the enhancement features, wherein the fluid flow is mixed throughout the open region. a fluid inlet; a fluid outlet; and a substrate in fluid communication with the fluid inlet and fluid outlet, the substrate comprises a heat exchange region having a heat transfer surface and a flow field adjacent the heat transfer surface, the flow field comprises a fluid flow area comprising an open region throughout the flow field, a positive taper of the flow field cross-sectional area in the fluid flow direction, and a heat transfer region in thermal communication with the heat exchange region, wherein the flow field heat transfer region comprises a plurality of open enhancement features from about 1 micron to about 3 mm in height, and the open region being a region of the flow field containing a gap above the enhancement features, wherein the fluid flow is mixed throughout the open region.
A BET bromodomain inhibitor selected from 1-benzyl-6-(3,5-dimethylisoxazol-4-yl)-N-methyl-1H-imidazo[4,5-b]pyridin-2-amine (Compound I) and pharmaceutically acceptable salts/co-crystals thereof, for use in a method of treating estrogen receptor positive (ER+) breast cancer in a patient, the method comprising administering said BET bromodomain inhibitor in combination with a second therapeutic agent, wherein the second therapeutic agent is fulvestrant or the second therapeutic agent is abemaciclib.
A cosmetic composition comprising the following components to: 0.3 to 1.5 mass% of a copolymer or crosspolymer which comprises, as a constituent unit, a combination of either an acrylic acid salt and 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof, or of a hydroxyethyl acrylate and 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof; polyacrylamide; or a mixture thereof; 0.3 to 3 mass% of a polyglycerol fatty acid ester; 13 to 31 mass% of a polyhydric alcohol; 2 to 18 mass% of a liquid oil having a melting point of 30°C or lower; and 2 to 8 mass% of a tanning agent, wherein the component comprises 70 mass% or more of a fatty acid triglyceride having at least one fatty acid group having 5 to 22 carbon atoms; and having a viscosity of from 3,000 to 12,000 mPa·s. 0.3 to 1.5 mass% of a copolymer or crosspolymer which comprises, as a constituent unit, a combination of either an acrylic acid salt and 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof, or of a hydroxyethyl acrylate and 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof; polyacrylamide; or a mixture thereof; 0.3 to 3 mass% of a polyglycerol fatty acid ester; 13 to 31 mass% of a polyhydric alcohol; 2 to 18 mass% of a liquid oil having a melting point of 30°C or lower; and 2 to 8 mass% of a tanning agent,
A ferrite particle, having a porous structure in an interior thereof and an outer shell structure on an outer periphery thereof, wherein the ferrite particle has a pore volume as measured according to the description of 0.006 to 0.02 ml/g and a peak pore size as measured according to the description of 0.7 to 2 μm, and wherein the ferrite particle contains 0.5 to 4% by weight of Mg and 63 to 70% by weight of Fe.
Vibration-isolating insert (1; 51; 61) for a pipe clip, the vibration-isolating insert (1; 51; 61) being adapted to bear against an inner circumference of a substantially annular pipe clip body and ultimately - in use - to be positioned between the outer circumference of a pipe and the pipe clip body, the vibration-isolating insert (1; 51; 61) comprising an elongate strip (2; 52) of vibration-isolating material and having a pipe clip facing side and a pipe facing side, wherein the pipe facing side has a plurality of longitudinal ribs (5, 6; 55, 56; 66), wherein: at each of the lateral edges of the strip a rib (6; 56; 66) is provided having a tip made of a material with a lower friction coefficient than the vibration isolating material of the strip, wherein said material with the lower friction coefficient has a greater hardness than said vibration-isolating material, at least one longitudinal rib (5; 55) made of the vibration isolating material is located between the ribs (6; 56; 66) at the lateral edges, the ribs at the lateral edges stand out above the at least one rib between them, the at least one longitudinal rib (5, 55) located between the ribs (6, 56, 66) at the lateral edges has a tip made of the vibration isolating material, characterised in that the ribs (6, 56, 66) at the lateral edges are made entirely or for the larger part of said material with the lower friction coefficient. at each of the lateral edges of the strip a rib (6; 56; 66) is provided having a tip made of a material with a lower friction coefficient than the vibration isolating material of the strip, wherein said material with the lower friction coefficient has a greater hardness than said vibration-isolating material, at least one longitudinal rib (5; 55) made of the vibration isolating material is located between the ribs (6; 56; 66) at the lateral edges, the ribs at the lateral edges stand out above the at least one rib between them, the at least one longitudinal rib (5, 55) located between the ribs (6, 56, 66) at the lateral edges has a tip made of the vibration isolating material, characterised in that the ribs (6, 56, 66) at the lateral edges are made entirely or for the larger part of said material with the lower friction coefficient.
A crate for the transport of motor vehicles, for fitting in a shipping container, the crate comprising a rectangular base having left and right sides and front and rear ends, left and right hand side walls connected along the respective sides of the base, each side wall carrying at a front end and a rear end a pivoting frame member (40, 42, 44, 46), characterised in that: each frame member comprises a first leaf and a second leaf, a first end of the first leaf being connected to an end of the side wall and a second end connected to a first end of the second leaf; the crate further comprises one or more deployable support members moveable between a retracted position and a deployed position; and the one or more support members are securable in the deployed position to hold the crate at an angle. each frame member comprises a first leaf and a second leaf, a first end of the first leaf being connected to an end of the side wall and a second end connected to a first end of the second leaf; the crate further comprises one or more deployable support members moveable between a retracted position and a deployed position; and the one or more support members are securable in the deployed position to hold the crate at an angle.
A bobbin conveying tray onto which a bobbin (5, 5A, 5B) with a yarn wound is attachable, the bobbin conveying tray comprising: a tray main body including a protrusion adapted to be inserted to the bobbin (5, 5A, 5B) to hold the bobbin (5, 5A, 5B), and being formed with an airflow passing hole that passes through the tray main body from an upper end to a lower surface; and a net member made of metal and fixed in the airflow passing hole; wherein metal wires forming the net of the net member are coupled to each other to regulate a movement of the metal wires at an intersecting position of the metal wires, characterized in that the metal wires are welded to each other by sintering. a tray main body including a protrusion adapted to be inserted to the bobbin (5, 5A, 5B) to hold the bobbin (5, 5A, 5B), and being formed with an airflow passing hole that passes through the tray main body from an upper end to a lower surface; and a net member made of metal and fixed in the airflow passing hole; wherein metal wires forming the net of the net member are coupled to each other to regulate a movement of the metal wires at an intersecting position of the metal wires, characterized in that the metal wires are welded to each other by sintering.
Use of an aromatic sulfonate compound as agent which increases the glass transition temperature of a polyamide, characterized in that the sulfonate compound is represented by the general formula: n -Y-(SO 3 X) m in which: - SO 3 X represents SO 3 H or SO 3 M; M being a group which replaces the proton H + of SO 3 H in order to form an inactive salified group, - m is between 1 and 10, - Y is a polyvalent aromatic hydrocarbon radical comprising from 2 to 100 carbon atoms, which can comprise heteroatoms, - Z is a functional group which can react with the amine or carboxylic acid functional groups of the monomers of the polyamide, - n is between 1 and 10, and in that the polyamide is chosen from the group consisting of the polyamides obtained by polycondensation of at least one linear dicarboxylic acid with a linear or cyclic diamine or between at least one aromatic dicarboxylic acid and a linear or aromatic diamine, the polyamides obtained by polycondensation of at least one amino acid with itself, it being possible for the amino acid to be generated by the hydrolytic opening of a lactam ring. - SO 3 X represents SO 3 H or SO 3 M; M being a group which replaces the proton H + of SO 3 H in order to form an inactive salified group, - m is between 1 and 10, - Y is a polyvalent aromatic hydrocarbon radical comprising from 2 to 100 carbon atoms, which can comprise heteroatoms, - Z is a functional group which can react with the amine or carboxylic acid functional groups of the monomers of the polyamide, - n is between 1 and 10,
An imaging detector, comprising: a digital image sensor configured to generate a plurality of signals in response to x-rays incident on the sensor; characterized by: a first processor communicatively coupled to the digital image sensor and configured to receive the plurality of signals and generate a digital representation of an x-ray image based on the plurality of signals, and a second processor configured to generate a user interface and to cause a digital image based on the digital representation of the x-ray image to be displayed via the user interface, and wherein the first processor is configured to enter a first idle state while the second processor is in a second active state or the second processor is configured to enter a second idle state while the first processor is in a first active state. a digital image sensor configured to generate a plurality of signals in response to x-rays incident on the sensor; characterized by: a first processor communicatively coupled to the digital image sensor and configured to receive the plurality of signals and generate a digital representation of an x-ray image based on the plurality of signals, and a second processor configured to generate a user interface and to cause a digital image based on the digital representation of the x-ray image to be displayed via the user interface, and wherein the first processor is configured to enter a first idle state while the second processor is in a second active state or the second processor is configured to enter a second idle state while the first processor is in a first active state. a first processor communicatively coupled to the digital image sensor and configured to receive the plurality of signals and generate a digital representation of an x-ray image based on the plurality of signals, and a second processor configured to generate a user interface and to cause a digital image based on the digital representation of the x-ray image to be displayed via the user interface, and wherein the first processor is configured to enter a first idle state while the second processor is in a second active state or the second processor is configured to enter a second idle state while the first processor is in a first active state.
A door for a file shredder for closing at least one interior space that is open on one side and provided below a cutting tool in a housing of the file shredder, comprising: - at least one viewing window, and - hinges for attachment at the housing, - wherein the door is assembled from two profile elements (2, 10), characterized in that at least one of the profile elements (2, 10) is made from a translucent material. - at least one viewing window, and - hinges for attachment at the housing, - wherein the door is assembled from two profile elements (2, 10),
A multi-layer electrophotographic photosensitive member comprising a conductive substrate and a photosensitive layer, wherein the photosensitive layer includes a charge generating layer that contains a charge generating material and a charge transport layer that contains a hole transport material and a binder resin, the charge generating material contains a titanyl phthalocyanine that exhibits a peak at a Bragg angle (2θ±0.2°) of 27.2° in a CuKα characteristic X-ray diffraction spectrum, the hole transport material contains a triarylamine derivative represented by generic formula shown below, and the hole transport material has a mass ratio of at least 0.30 and no greater than 0.55 relative to the binder resin in the charge transport layer, where in the general formula, R 1 and R 2 represent, independently of one another, a halogen atom, an optionally substituted alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, or an optionally substituted aryl group having a carbon number of at least 6 and no greater than 12, k and 1 represent, independently of one another, an integer of at least 0 and no greater than 4, when k represents an integer greater than 1, a plurality of chemical groups R 1 bonded to the same aromatic ring are the same as or different from one another, when 1 represents an integer greater than 1, a plurality of chemical groups R 2 bonded to the same aromatic ring are the same as or different from one another, m and n represent, independently of one another, an integer of at least 1 and no greater than 3, and m and n represent integers different from one another. R 1 and R 2 represent, independently of one another, a halogen atom, an optionally substituted alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, or an optionally substituted aryl group having a carbon number of at least 6 and no greater than 12, k and 1 represent, independently of one another, an integer of at least 0 and no greater than 4, when k represents an integer greater than 1, a plurality of chemical groups R 1 bonded to the same aromatic ring are the same as or different from one another, when 1 represents an integer greater than 1, a plurality of chemical groups R 2 bonded to the same aromatic ring are the same as or different from one another, m and n represent, independently of one another, an integer of at least 1 and no greater than 3, and m and n represent integers different from one another.
A method of producing a handheld videogame controller using a circuit board of a predetermined fixed size, comprising a plurality of switches at predetermined positions, the method characterised by: obtaining measurements of at least a first hand of a user for whom the handheld videogame controller is to be produced; modifying, by a computer, a design of at least a first part of the handheld videogame controller responsive to the measurements; and 3D printing the or each modified part of the handheld videogame controller, wherein the step of modifying the design of at least a first part of the handheld videogame controller comprises repositioning a button (336, 346) that should mechanically couple to a switch on the circuit board, and the design is further modified to adapt the mechanical linkage between the repositioned button and the switch in order to maintain the mechanical coupling, wherein the mechanical coupling is maintained by repositioning a protrusion underneath the repositioned button, said protrusion serving as said mechanical linkage that maintains the relative position with the fixed switch beneath the repositioned button, or, if the button is repositioned such that the fixed switch no longer is beneath the button, by changing the protrusion to an L-shape that extends beyond the button such that a part of the protrusion maintains the relative position with the fixed switch. obtaining measurements of at least a first hand of a user for whom the handheld videogame controller is to be produced; modifying, by a computer, a design of at least a first part of the handheld videogame controller responsive to the measurements; and 3D printing the or each modified part of the handheld videogame controller, wherein the step of modifying the design of at least a first part of the handheld videogame controller comprises repositioning a button (336, 346) that should mechanically couple to a switch on the circuit board, and the design is further modified to adapt the mechanical linkage between the repositioned button and the switch in order to maintain the mechanical coupling, wherein the mechanical coupling is maintained by repositioning a protrusion underneath the repositioned button, said protrusion serving as said mechanical linkage that maintains the relative position with the fixed switch beneath the repositioned button, or, if the button is repositioned such that the fixed switch no longer is beneath the button, by changing the protrusion to an L-shape that extends beyond the button such that a part of the protrusion maintains the relative position with the fixed switch.
Elastically flexible hollow profile, having an electrically operating switching strip which is firmly integrated in a chamber of the hollow profile, and having a sheath made of an elastomer, which can be activated when the hollow profile is deformed, characterized in that the switching strip, with its sheath, projects freely beyond the hollow profile at at least one end of the hollow profile.
Electric heating device, particularly for an automotive vehicle, comprising a housing which encloses a circulation chamber through which a medium can flow and into which at least one heating rib projects that opens towards a connection chamber into which electric connection elements (28.1) of at least one electric heating element of the heating rib project, the connection elements (28.1) being electrically connected via a connection circuit board, characterized in that the connection circuit board is configured to extend laterally beyond the housing and is passed through a connection-circuit-board connection opening of a control housing, and that conductor paths formed on the connection circuit board are directly contacted with conductor paths of a control circuit board which is received in the control housing.
Control valve device for a highly available pneumatic brake system for a rail vehicle, comprising - a compressed air input, which is or can be connected to an output of a triggering valve device, and via which a defined input pressure (Cv1max) can be fed to the control valve device; - a compressed air output, which is or can be connected to a of a relay valve device and via which an output pressure can be fed to the relay valve device; and - a safety input, which is or can be connected to a compressed air supply (44, 20); characterised in that in a first switching position the control valve device fluidically connects the safety input to the compressed air output and in a second switching position it fluidically connects the compressed air input to the compressed air output; wherein in the second switching position the control valve device is designed to modify the input pressure according to a control device in order to provide the output pressure. - a compressed air input, which is or can be connected to an output of a triggering valve device, and via which a defined input pressure (Cv1max) can be fed to the control valve device; - a compressed air output, which is or can be connected to a of a relay valve device and via which an output pressure can be fed to the relay valve device; and - a safety input, which is or can be connected to a compressed air supply (44, 20);