A compound having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein: X is -S n - or -C(R 8 R 9)-; R 1 is H, hydroxyl or -OC(=O)R 13; R 2 is hydroxyl or -OC(=O)R 13; R 3 is: i) an optionally substituted 5 or 6 membered heteroaryl or an optionally substituted 3 to 7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl respectively comprise at least one N atom, wherein the optional substituent is one or more R 6; ii) pyrrole, furan, thiophene, pyrazole, pyridine, pyridazine, pyrimidine, imidazole, thiazole, isoxazole, oxadiazole, thiadiazole, oxazole, triazole, isothiazole, oxazine, triazine, azepine, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine, or tetrazine; or iii) -NH 2, -NHC(=O)R 13, -N(C(=O)R 13) 2, -NHS n R 5, -N(C(=O)R 13)(S n R 5), - N(C 1 -C 6 alkyl)(S n R 5) or -S n R 5; R 5 is each independently C 1 -C 6 alkyl or aryl which are optionally substituted with one or more R 6; R 6 is each independently selected from the group consisting of H, F, Cl, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl; R 8 and R 9 are each independently H or C 1 -C 6 alkyl; R 11a, R 11b, R 11c and R 11d are each independently H, methyl, F, Cl, Br, I, or 123 I; R 13 is C 1 -C 6 alkyl; and n is 0, 1, or 2; wherein at least two of R 11a, R 11b, R 11c and R 11d are methyl, F, Cl, Br, I, or 123 I. X is -S n - or -C(R 8 R 9)-; R 1 is H, hydroxyl or -OC(=O)R 13; R 2 is hydroxyl or -OC(=O)R 13; R 3 is: i) an optionally substituted 5 or 6 membered heteroaryl or an optionally substituted 3 to 7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl respectively comprise at least one N atom, wherein the optional substituent is one or more R 6; ii) pyrrole, furan, thiophene, pyrazole, pyridine, pyridazine, pyrimidine, imidazole, thiazole, isoxazole, oxadiazole, thiadiazole, oxazole, triazole, isothiazole, oxazine, triazine, azepine, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine, or tetrazine; or iii) -NH 2, -NHC(=O)R 13, -N(C(=O)R 13) 2, -NHS n R 5, -N(C(=O)R 13)(S n R 5), - N(C 1 -C 6 alkyl)(S n R 5) or -S n R 5; i) an optionally substituted 5 or 6 membered heteroaryl or an optionally substituted 3 to 7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl respectively comprise at least one N atom, wherein the optional substituent is one or more R 6; ii) pyrrole, furan, thiophene, pyrazole, pyridine, pyridazine, pyrimidine, imidazole, thiazole, isoxazole, oxadiazole, thiadiazole, oxazole, triazole, isothiazole, oxazine, triazine, azepine, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, dioxane, morpholine, dithiane, thiomorpholine, piperazine, or tetrazine; or iii) -NH 2, -NHC(=O)R 13, -N(C(=O)R 13) 2, -NHS n R 5, -N(C(=O)R 13)(S n R 5), - N(C 1 -C 6 alkyl)(S n R 5) or -S n R 5; R 5 is each independently C 1 -C 6 alkyl or aryl which are optionally substituted with one or more R 6; R 6 is each independently selected from the group consisting of H, F, Cl, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl; R 8 and R 9 are each independently H or C 1 -C 6 alkyl; R 11a, R 11b, R 11c and R 11d are each independently H, methyl, F, Cl, Br, I, or 123 I; R 13 is C 1 -C 6 alkyl; and n is 0, 1, or 2;