A nanopore sensor system comprising: a plurality of independent nanopore sensors; a first fluidic reservoir (cis), shared by all of the independent nanopore sensors in the plurality of independent nanopore sensors, with a first ionic solution of a first ionic concentration disposed in the first fluidic reservoir (cis); a second fluidic reservoir (trans), shared by all of the independent nanopore sensors in the plurality of independent nanopore sensors, with a second ionic solution of a second ionic concentration; each independent nanopore sensor in the plurality of independent nanopore sensors comprising: a nanopore disposed in a support structure; a fluidic connection between the first fluidic reservoir (cis), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an inlet to the nanopore; a fluidic connection between the second fluidic reservoir (trans), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an outlet from the nanopore; characterized in that the second ionic concentration is different than the first ionic concentration; and an electrical transduction element is disposed in contact with that ionic solution of the first and second ionic solutions which has a lower ionic concentration, the electrical transduction element being arranged at a site that produces in the electrical transduction element an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration; wherein an electrical circuit is connected to the transduction element of each independent nanopore sensor in the plurality of independent nanopore sensors, and includes a circuit element adapted to produce an electrical signal indicative of the electrical potential local to that ionic solution having a lower ionic concentration; and wherein each nanopore sensor in the plurality of independent nanopore sensors is configured to detect translocation of species from one reservoir (cis) through the nanopore to the other reservoir (trans) based on changes in the electrical signal. a plurality of independent nanopore sensors; a first fluidic reservoir (cis), shared by all of the independent nanopore sensors in the plurality of independent nanopore sensors, with a first ionic solution of a first ionic concentration disposed in the first fluidic reservoir (cis); a second fluidic reservoir (trans), shared by all of the independent nanopore sensors in the plurality of independent nanopore sensors, with a second ionic solution of a second ionic concentration; each independent nanopore sensor in the plurality of independent nanopore sensors comprising: a nanopore disposed in a support structure; a fluidic connection between the first fluidic reservoir (cis), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an inlet to the nanopore; a fluidic connection between the second fluidic reservoir (trans), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an outlet from the nanopore; characterized in that the second ionic concentration is different than the first ionic concentration; and an electrical transduction element is disposed in contact with that ionic solution of the first and second ionic solutions which has a lower ionic concentration, the electrical transduction element being arranged at a site that produces in the electrical transduction element an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration; a nanopore disposed in a support structure; a fluidic connection between the first fluidic reservoir (cis), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an inlet to the nanopore; a fluidic connection between the second fluidic reservoir (trans), common to all of the independent nanopore sensors in the plurality of independent nanopore sensors, and an outlet from the nanopore; characterized in that the second ionic concentration is different than the first ionic concentration; and an electrical transduction element is disposed in contact with that ionic solution of the first and second ionic solutions which has a lower ionic concentration, the electrical transduction element being arranged at a site that produces in the electrical transduction element an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration; wherein an electrical circuit is connected to the transduction element of each independent nanopore sensor in the plurality of independent nanopore sensors, and includes a circuit element adapted to produce an electrical signal indicative of the electrical potential local to that ionic solution having a lower ionic concentration; and wherein each nanopore sensor in the plurality of independent nanopore sensors is configured to detect translocation of species from one reservoir (cis) through the nanopore to the other reservoir (trans) based on changes in the electrical signal.