A composition comprising biocompatible magnetic, magnetizable, or magnetically responsive agents for use in the treatment of a condition affecting a tooth or periodontium in a subject by administering the composition to the subject's tooth or periodontium, wherein the magnetic, magnetizable, or magnetically responsive agents migrate through dentinal tubules to a desired location in response to an externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject, wherein the magnetic, magnetizable, or magnetically responsive agents comprise particles, fluids, rods or cubes, wherein average diameter of the magnetic, magnetizable, or magnetically responsive agents range from 10 nm to 1500 nm, wherein the composition is applied to a surface of dentin, wherein the composition comprises an effective amount of one or more therapeutic agents, wherein at least one therapeutic agent is bound to the magnetic, magnetizable, or magnetically responsive agents chemically, ionically, covalently, non-covalently, using a thin film rehydration method, by dialysis, by mechanical absorption polymerization or a combination thereof, wherein the condition affecting the tooth or periodontium is selected from the group consisting of inflammation, pulpitis, infection, pain, sensitivity, caries (tooth decay), structural loss, gingivitis, periodontitis, periodontal disease, pericoronitis, and osteoradionecrosis, medication induced necrosis of the bone, atrophy and abscess, wherein the therapeutic agent is selected from the group consisting of an immunosuppressant, an analgesic, an antibody, an antibiotic, an anti-fungal, recombinant RNA, recombinant DNA, lipopolysaccharides, a therapeutic protein, and combinations thereof. wherein the magnetic, magnetizable, or magnetically responsive agents migrate through dentinal tubules to a desired location in response to an externally applied magnetic field, thereby treating a condition affecting the tooth or periodontium in the subject, wherein the magnetic, magnetizable, or magnetically responsive agents comprise particles, fluids, rods or cubes, wherein average diameter of the magnetic, magnetizable, or magnetically responsive agents range from 10 nm to 1500 nm, wherein the composition is applied to a surface of dentin, wherein the composition comprises an effective amount of one or more therapeutic agents, wherein at least one therapeutic agent is bound to the magnetic, magnetizable, or magnetically responsive agents chemically, ionically, covalently, non-covalently, using a thin film rehydration method, by dialysis, by mechanical absorption polymerization or a combination thereof, wherein the condition affecting the tooth or periodontium is selected from the group consisting of inflammation, pulpitis, infection, pain, sensitivity, caries (tooth decay), structural loss, gingivitis, periodontitis, periodontal disease, pericoronitis, and osteoradionecrosis, medication induced necrosis of the bone, atrophy and abscess, wherein the therapeutic agent is selected from the group consisting of an immunosuppressant, an analgesic, an antibody, an antibiotic, an anti-fungal, recombinant RNA, recombinant DNA, lipopolysaccharides, a therapeutic protein, and combinations thereof.