A medical device system comprising: a stimulation generator configured to deliver electrical stimulation to a patient; one or more sensors configured to sense compound action potentials in a tissue of the patient evoked by the electrical stimulation therapy; and a processor configured to: control delivery of an electrical stimulation therapy from the stimulation generator to the patient according to at least one therapy program, wherein the electrical stimulation therapy is configured to provide pain relief to the patient without substantially resulting in paresthesia perceived by the patient; determining, using the one or more sensors, that an evoked compound action potential occurs and suspending delivery of the electrical stimulation therapy for a predetermined amount of time; resume delivery of the electrical stimulation therapy after the predetermined amount of time; and periodically adjust one or more stimulation parameters of the electrical stimulation therapy delivered to the patient in response to further detected compound action potentials after expiration of the predetermined time period and after resuming delivery of the electrical stimulation therapy, wherein the adjustment to the one or more stimulation parameters of the electrical stimulation therapy is configured to eliminate action potentials in tissue of the patient evoked by the delivered electrical stimulation. a stimulation generator configured to deliver electrical stimulation to a patient; one or more sensors configured to sense compound action potentials in a tissue of the patient evoked by the electrical stimulation therapy; and a processor configured to: control delivery of an electrical stimulation therapy from the stimulation generator to the patient according to at least one therapy program, wherein the electrical stimulation therapy is configured to provide pain relief to the patient without substantially resulting in paresthesia perceived by the patient; determining, using the one or more sensors, that an evoked compound action potential occurs and suspending delivery of the electrical stimulation therapy for a predetermined amount of time; resume delivery of the electrical stimulation therapy after the predetermined amount of time; and periodically adjust one or more stimulation parameters of the electrical stimulation therapy delivered to the patient in response to further detected compound action potentials after expiration of the predetermined time period and after resuming delivery of the electrical stimulation therapy, wherein the adjustment to the one or more stimulation parameters of the electrical stimulation therapy is configured to eliminate action potentials in tissue of the patient evoked by the delivered electrical stimulation. control delivery of an electrical stimulation therapy from the stimulation generator to the patient according to at least one therapy program, wherein the electrical stimulation therapy is configured to provide pain relief to the patient without substantially resulting in paresthesia perceived by the patient; determining, using the one or more sensors, that an evoked compound action potential occurs and suspending delivery of the electrical stimulation therapy for a predetermined amount of time; resume delivery of the electrical stimulation therapy after the predetermined amount of time; and periodically adjust one or more stimulation parameters of the electrical stimulation therapy delivered to the patient in response to further detected compound action potentials after expiration of the predetermined time period and after resuming delivery of the electrical stimulation therapy, wherein the adjustment to the one or more stimulation parameters of the electrical stimulation therapy is configured to eliminate action potentials in tissue of the patient evoked by the delivered electrical stimulation.