A plication lock delivery system for creating a tissue plication comprising: a lock assembly comprising a lock body and a lock pin, wherein the lock body has a central lumen configured to retain the lock pin and to have a first and a second sutures (16, 18) disposed within the central lumen; a catheter assembly comprising an outer sheath and an inner catheter, wherein the inner catheter has a distal end, a proximal end, and a central lumen, wherein the distal end of the inner catheter is configured to detachably connect to the lock body, wherein the central lumen is configured to have the first and the second sutures (16, 18) disposed within, wherein the outer sheath has a distal end and a proximal end, wherein the distal end is configured to contact the lock pin and cause movement thereof; and a control assembly comprising a first suture tension mechanism configured to apply tension to a first suture, a second suture tension mechanism configured to apply tension to a second suture, and a lock deploy-and-release mechanism configured to secure the first and the second sutures (16, 18) to the lock assembly and to release the lock assembly from the catheter assembly at a target site; wherein the control assembly is operatively coupled to the proximal ends of the outer sheath and inner catheter; wherein the lock body further includes a first locking slot formed therein and extending along a longitudinal length thereof, the first locking slot intersecting the central lumen, characterized in that the lock body further includes a side opening that is open along a side of the lock body and communicates with the central lumen and a second opening that is open at a proximal end of the lock body, the second opening being spaced and separate from the longitudinal lumen, wherein the side opening intersects and passes through the second opening. a lock assembly comprising a lock body and a lock pin, wherein the lock body has a central lumen configured to retain the lock pin and to have a first and a second sutures (16, 18) disposed within the central lumen; a catheter assembly comprising an outer sheath and an inner catheter, wherein the inner catheter has a distal end, a proximal end, and a central lumen, wherein the distal end of the inner catheter is configured to detachably connect to the lock body, wherein the central lumen is configured to have the first and the second sutures (16, 18) disposed within, wherein the outer sheath has a distal end and a proximal end, wherein the distal end is configured to contact the lock pin and cause movement thereof; and a control assembly comprising a first suture tension mechanism configured to apply tension to a first suture, a second suture tension mechanism configured to apply tension to a second suture, and a lock deploy-and-release mechanism configured to secure the first and the second sutures (16, 18) to the lock assembly and to release the lock assembly from the catheter assembly at a target site; wherein the control assembly is operatively coupled to the proximal ends of the outer sheath and inner catheter; wherein the lock body further includes a first locking slot formed therein and extending along a longitudinal length thereof, the first locking slot intersecting the central lumen,