A medical waste collection system for collecting medical waste material through a manifold during a medical procedure, the medical waste collection system comprising: a waste container (106, 108); a receiver coupled to the waste container (106, 108) and comprising a housing defining an opening into which the manifold is configured to be inserted in a proximal direction and removed in a distal direction opposite the proximal direction, wherein the receiver comprises: a sled assembly movably coupled to the housing; a locking assembly comprising: a locking member; a release member; characterized in that the sled assembly is configured to be engaged by the manifold during insertion of the manifold into the receiver, the locking member of the locking assembly has an engagement surface, and the release member is coupled to the locking member, wherein the locking assembly further comprises: a biasing element biasing the locking assembly to a locked configuration in which the engagement surface engages the manifold in a fully inserted operative position to prevent distal movement of the manifold and the sled assembly; and an actuator coupled to the release member and configured to receive an input from a user to move the locking assembly from the locked configuration to an unlocked configuration in which the engagement surface disengages from the manifold to permit the distal movement of the manifold and the sled assembly. a waste container (106, 108); a receiver coupled to the waste container (106, 108) and comprising a housing defining an opening into which the manifold is configured to be inserted in a proximal direction and removed in a distal direction opposite the proximal direction, wherein the receiver comprises: a sled assembly movably coupled to the housing; a locking assembly comprising: a locking member; a release member; a sled assembly movably coupled to the housing; a locking assembly comprising: a locking member; a release member; a locking member; a release member; the locking member of the locking assembly has an engagement surface, and the release member is coupled to the locking member, wherein the locking assembly further comprises: a biasing element biasing the locking assembly to a locked configuration in which the engagement surface engages the manifold in a fully inserted operative position to prevent distal movement of the manifold and the sled assembly; and an actuator coupled to the release member and configured to receive an input from a user to move the locking assembly from the locked configuration to an unlocked configuration in which the engagement surface disengages from the manifold to permit the distal movement of the manifold and the sled assembly. a biasing element biasing the locking assembly to a locked configuration in which the engagement surface engages the manifold in a fully inserted operative position to prevent distal movement of the manifold and the sled assembly; and an actuator coupled to the release member and configured to receive an input from a user to move the locking assembly from the locked configuration to an unlocked configuration in which the engagement surface disengages from the manifold to permit the distal movement of the manifold and the sled assembly.