A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Ar is C 6 -C 10 aryl or six to ten membered heteroaryl containing one, two or three heteroatoms selected from N, O, and S; wherein the C 6 -C 10 aryl or six to ten membered heteroaryl is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, and C 1 -C 6 alkyloxy; R 1 is H, C 1 -C 3 alkyl or phenyl; R 2 is H or C 1 -C 3 alkyl; R 3 is H or C 1 -C 3 alkyl; R 4 and R 5 are each independently H, halogen, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 6 -C 10 aryl, or six to ten membered heteroaryl containing one, two or three heteroatoms selected from N, O, and S; wherein the C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 6 -C 10 aryl, or six to ten membered heteroaryl is optionally substituted with one, two or three groups independently selected from halogen, C 1 -C 3 alkyloxy, or C 1 -C 3 haloalkyloxy; or R 4 and R 5 are joined together to form a 3-6 membered carbocyclic ring or 4-6 membered heterocyclic ring comprising one heteroatom selected from N, O, and S; R 6 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy or C 1 -C 6 haloalkyl; R 7 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, or C 1 -C 6 haloalkyl; R 8A and R 8B are independently H, C 1 -C 3 alkyl or benzyl; and -X-Y- is -(CR 13A R 13B) p -CR 9 =CR 10 -; wherein R 9 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; R 10 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; and R 13A and R 13B are each independently H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy; or C 1 -C 6 haloalkyl; and p is 0 or 1. Ar is C 6 -C 10 aryl or six to ten membered heteroaryl containing one, two or three heteroatoms selected from N, O, and S; wherein the C 6 -C 10 aryl or six to ten membered heteroaryl is optionally substituted with 1-4 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, and C 1 -C 6 alkyloxy; R 1 is H, C 1 -C 3 alkyl or phenyl; R 2 is H or C 1 -C 3 alkyl; R 3 is H or C 1 -C 3 alkyl; R 4 and R 5 are each independently H, halogen, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 6 -C 10 aryl, or six to ten membered heteroaryl containing one, two or three heteroatoms selected from N, O, and S; wherein the C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 6 -C 10 aryl, or six to ten membered heteroaryl is optionally substituted with one, two or three groups independently selected from halogen, C 1 -C 3 alkyloxy, or C 1 -C 3 haloalkyloxy; or R 4 and R 5 are joined together to form a 3-6 membered carbocyclic ring or 4-6 membered heterocyclic ring comprising one heteroatom selected from N, O, and S; R 6 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy or C 1 -C 6 haloalkyl; R 7 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, or C 1 -C 6 haloalkyl; R 8A and R 8B are independently H, C 1 -C 3 alkyl or benzyl; and -X-Y- is -(CR 13A R 13B) p -CR 9 =CR 10 -; wherein R 9 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; R 10 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; and R 13A and R 13B are each independently H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy; or C 1 -C 6 haloalkyl; and p is 0 or 1. R 9 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; R 10 is H, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkyloxy; and R 13A and R 13B are each independently H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy; or C 1 -C 6 haloalkyl; and p is 0 or 1.