A pseudotyped retrovirus-like particle or retroviral vector comprising: a) at least one cell targeting fusion protein comprising (i) a protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family and (ii) at least one cell targeting domain selected from the group consisting of a DARPin, ScFv, targeting peptide and their combinations, wherein the protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family: (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, b) at least one modulating fusion protein comprising (i) a protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family or a transmembrane domain and (ii) at least one functional domain chosen from a cytokine, growth factor, hormone, neurotransmitter, apoptosis ligand, or a combination thereof, wherein the protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family: (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, and c) at least one glycoprotein comprising at least one modification by comparison to the sequence of the envelope glycoprotein F of a virus of the Paramyxoviridae family and comprising a protein having at least 80% sequence identity to SEQ ID NO: 11 or SEQ ID NO: 12. a) at least one cell targeting fusion protein comprising (i) a protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family and (ii) at least one cell targeting domain selected from the group consisting of a DARPin, ScFv, targeting peptide and their combinations, wherein the protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family: (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, b) at least one modulating fusion protein comprising (i) a protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family or a transmembrane domain and (ii) at least one functional domain chosen from a cytokine, growth factor, hormone, neurotransmitter, apoptosis ligand, or a combination thereof, wherein the protein derived from an envelope glycoprotein G or H of a virus of the Paramyxoviridae family: (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, and (i) comprises at least one modification by comparison to the sequence of the envelope glycoprotein G or H of a virus of the Paramyxoviridae family; (ii) lacks at least one part of the cytoplasmic region of said envelope glycoprotein G or H; and (iii) has at least 80% sequence identity to SEQ ID NO: 9 or SEQ ID NO: 10, and c) at least one glycoprotein comprising at least one modification by comparison to the sequence of the envelope glycoprotein F of a virus of the Paramyxoviridae family and comprising a protein having at least 80% sequence identity to SEQ ID NO: 11 or SEQ ID NO: 12.