A shoe with waterproof and vapor-permeable upper and sole, comprising - an upper assembly which at least comprises, in a stratified manner, a vapor-permeable or perforated outer upper, a vapor-permeable inner lining, and, between them, a functional element of the upper which is permeable to water vapor and impermeable to water in the liquid state, - an insole which is joined to said upper assembly and has at least one waterproof vapor permeation region, - a bottom with a sole which has a vapor permeation region provided at said at least one waterproof vapor permeation region, in order to allow the dissipation of water vapor that arrives from said insole, - said insole selectively comprising or being joined to at least one lower functional element which is permeable to water vapor and impermeable to water in the liquid state, - said waterproof vapor permeation region being formed substantially, on said at least one lower functional element, by at least one vapor-permeable protective element, which is arranged so as to be interposed between said at least one lower functional element and said bottom with sole, said lower functional element having at least one band which is perimetric to said waterproof vapor permeation region, not covered by said protective element, - a mutual waterproof seal being provided between said functional element of the upper, at said sealing band, and said at least one lower functional element at said band, said shoe being characterized in that said functional element of the upper is firmly joined to said upper so as to be fully adherent to a body of said upper and a sealing band wherein the functional element of the upper is joined to the upper by means of a thermally activatable adhesive distributed therebetween so as not to compromise vapor permeability of the functional element of the upper and the upper, said upper ending toward said insole with said sealing band, which is covered at least partly by the edge of said functional element of the upper, said sealing band and said edge being associated with a perimetric rim of said insole. - an upper assembly which at least comprises, in a stratified manner, a vapor-permeable or perforated outer upper, a vapor-permeable inner lining, and, between them, a functional element of the upper which is permeable to water vapor and impermeable to water in the liquid state, - an insole which is joined to said upper assembly and has at least one waterproof vapor permeation region, - a bottom with a sole which has a vapor permeation region provided at said at least one waterproof vapor permeation region, in order to allow the dissipation of water vapor that arrives from said insole, - said insole selectively comprising or being joined to at least one lower functional element which is permeable to water vapor and impermeable to water in the liquid state, - said waterproof vapor permeation region being formed substantially, on said at least one lower functional element, by at least one vapor-permeable protective element, which is arranged so as to be interposed between said at least one lower functional element and said bottom with sole, said lower functional element having at least one band which is perimetric to said waterproof vapor permeation region, not covered by said protective element, - a mutual waterproof seal being provided between said functional element of the upper, at said sealing band, and said at least one lower functional element at said band, said shoe being characterized in that said functional element of the upper is firmly joined to said upper so as to be fully adherent to a body of said upper and a sealing band wherein the functional element of the upper is joined to the upper by means of a thermally activatable adhesive distributed therebetween so as not to compromise vapor permeability of the functional element of the upper and the upper, said upper ending toward said insole with said sealing band, which is covered at least partly by the edge of said functional element of the upper, said sealing band and said edge being associated with a perimetric rim of said insole.