A closed system transfer device (CSTD) arrangement for storing a beneficial agent and transferring the beneficial agent to a destination port, the CSTD arrangement comprising: a primary container comprising a package for storing the beneficial agent comprising at least one flexible wall such that pressure in the primary container is substantially equalized to ambient pressure; a metering pump; a delivery port for communicating the beneficial agent with the destination port; and a valve in selective fluid communication with the primary container, the metering pump, and the delivery port, the valve comprising a valve housing, wherein: the primary container extends from the valve housing, the metering pump is joined to the valve housing, the delivery port is an opening in the valve housing configured to accommodate the destination port, the valve is moveable from a first configuration where it is not engaged with the destination port, to a second configuration where it is engaged with the destination port, in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port, in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container, and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump. a primary container comprising a package for storing the beneficial agent comprising at least one flexible wall such that pressure in the primary container is substantially equalized to ambient pressure; a metering pump; a delivery port for communicating the beneficial agent with the destination port; and a valve in selective fluid communication with the primary container, the metering pump, and the delivery port, the valve comprising a valve housing, wherein: the primary container extends from the valve housing, the metering pump is joined to the valve housing, the delivery port is an opening in the valve housing configured to accommodate the destination port, the valve is moveable from a first configuration where it is not engaged with the destination port, to a second configuration where it is engaged with the destination port, in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port, in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container, and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump. the primary container extends from the valve housing, the metering pump is joined to the valve housing, the delivery port is an opening in the valve housing configured to accommodate the destination port, the valve is moveable from a first configuration where it is not engaged with the destination port, to a second configuration where it is engaged with the destination port, in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port, in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container, and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump.