A syringe-based device for delivering fluid comprising: (a) a housing having a proximal end portion and a distal end portion defining an inner volume; and (b) an actuator mechanism comprising; (i) a first member; and (ii) a second member configured to be movably disposed within the housing; characterized in that: the housing includes a port, the port being positioned at about the distal end portion of the housing; the second member comprises; (i) a plunger seal defining a channel; and (ii) a valve fluidically coupled with the channel of the plunger seal; the first member comprises; (i) a syringe body; and (ii) a plunger, the plunger being movably disposed within the syringe body and including a seal; the syringe-based device further comprises; (c) a first fluid reservoir configured to contain a first type of fluid, the first fluid reservoir being defined at least partially by the housing and the plunger seal; and (d) a second fluid reservoir configured to retain a second type of fluid, the second fluid reservoir being fluidically coupled with the valve and being fluidically sealed by the seal; wherein the syringe body and the plunger define an inner volume, and at least a portion of the inner volume is configured to define the second fluid reservoir; and the syringe-based device transitions from a first configuration to a second configuration in which the first type of fluid in the first fluid reservoir is delivered through the port, to a third configuration in which the second type of fluid within the second fluid reservoir is delivered through the port. (a) a housing having a proximal end portion and a distal end portion defining an inner volume; and (b) an actuator mechanism comprising; (i) a first member; and (ii) a second member configured to be movably disposed within the housing; characterized in that: the housing includes a port, the port being positioned at about the distal end portion of the housing; the second member comprises; (i) a plunger seal defining a channel; and (ii) a valve fluidically coupled with the channel of the plunger seal; the first member comprises; (i) a syringe body; and (ii) a plunger, the plunger being movably disposed within the syringe body and including a seal; the syringe-based device further comprises; (i) a first member; and (ii) a second member configured to be movably disposed within the housing; the housing includes a port, the port being positioned at about the distal end portion of the housing; the second member comprises; (i) a plunger seal defining a channel; and (ii) a valve fluidically coupled with the channel of the plunger seal; (i) a plunger seal defining a channel; and (ii) a valve fluidically coupled with the channel of the plunger seal; the first member comprises; (i) a syringe body; and (ii) a plunger, the plunger being movably disposed within the syringe body and including a seal; (i) a syringe body; and (ii) a plunger, the plunger being movably disposed within the syringe body and including a seal; the syringe-based device further comprises; (c) a first fluid reservoir configured to contain a first type of fluid, the first fluid reservoir being defined at least partially by the housing and the plunger seal; and (d) a second fluid reservoir configured to retain a second type of fluid, the second fluid reservoir being fluidically coupled with the valve and being fluidically sealed by the seal; wherein the syringe body and the plunger define an inner volume, and at least a portion of the inner volume is configured to define the second fluid reservoir; and the syringe-based device transitions from a first configuration to a second configuration in which the first type of fluid in the first fluid reservoir is delivered through the port, to a third configuration in which the second type of fluid within the second fluid reservoir is delivered through the port. wherein the syringe body and the plunger define an inner volume, and at least a portion of the inner volume is configured to define the second fluid reservoir; and the syringe-based device transitions from a first configuration to a second configuration in which the first type of fluid in the first fluid reservoir is delivered through the port, to a third configuration in which the second type of fluid within the second fluid reservoir is delivered through the port.