mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula A-I: or a stereoisomer or mixture of stereoisomers, tautomer, pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, isotopologue or polymorph thereof, wherein: R is H, optionally substituted alkyl, or optionally substituted cycloalkyl; R 1 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R 2 and R 3 are each halo; where the substituents on R 1, when present are one to three groups Q, where each Q is independently alkyl, halo, haloalkyl, hydroxyl, alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, -R 4 OR 5, -R 4 SR 5, - R 4 N(R 6)(R 7), R 4 OR 4 N(R 6)(R 7) or R 4 OR 4 C N(R 6)(R 7); J is O or S; each R 4 is independently alkylene, alkenylene or a direct bond; each R 5 is independently hydrogen, alkyl, haloalkyl or hydroxyalkyl; and R 6 and R 7 are each independently hydrogen or alkyl or R 6 and R 7 together with the nitrogen atom on which they are substituted form a 5 or 6-membered heterocyclyl or heteroaryl ring, optionally substituted with one or two halo, alkyl or haloalkyl. R is H, optionally substituted alkyl, or optionally substituted cycloalkyl; R 1 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R 2 and R 3 are each halo; where the substituents on R 1, when present are one to three groups Q, where each Q is independently alkyl, halo, haloalkyl, hydroxyl, alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, -R 4 OR 5, -R 4 SR 5, - R 4 N(R 6)(R 7), R 4 OR 4 N(R 6)(R 7) or R 4 OR 4 C N(R 6)(R 7); J is O or S; each R 4 is independently alkylene, alkenylene or a direct bond; each R 5 is independently hydrogen, alkyl, haloalkyl or hydroxyalkyl; and R 6 and R 7 are each independently hydrogen or alkyl or R 6 and R 7 together with the nitrogen atom on which they are substituted form a 5 or 6-membered heterocyclyl or heteroaryl ring, optionally substituted with one or two halo, alkyl or haloalkyl.
A retainer clip for use in retaining a protective sheet of covering material on a wall made of brick or similar construction elements, the retainer clip being formed of a resilient material such as metal or a plastics material and including a first and second arm (11, 12), substantially parallel to each other, said first and second arms (11, 12) being connected by a cross-piece maintaining a separation of the arms at a distance allowing the free ends of the arms to pass over the wall, the first arm including a stop member extending towards the second arm, which stop member in use rests on an upper surface of the wall and the sheet thereon and ensures the retainer clip is positioned correctly, wherein an arm includes a curved portion to define a wall-engaging region, characterised in that the end of the curved portion of an arm extends away from the other arm and, in use, from a wall.
A method of making Compound A or a salt thereof: comprising the steps of: (i) Reacting with to form followed by deprotecting Compound 13 to form wherein Compound 13 is not isolated prior to deprotection and PG is a protecting group. (ii) Coupling Compound 14 with to produce (iii) Without isolating Compound 16, hydrogenating Compound 16 to produce (iv) Without isolating Compound 21, lactamising Compound 21 to produce (v) Converting Compound 18 to and (vi) Coupling Compound 19 or salt thereof, to or salt thereof, wherein the coupling of step (vi) comprises the use of a coupling reagent and a compound selected from: wherein R 5 is either hydrogen, aryl, halogen, C 1-6 alkyl, OC 1-6 alkyl or C 3 -C 8 cycloalkyl, and wherein any of compounds 11, 12, 13, 14, 15, 16. 21 and 18 independently may be provided as salts. (i) Reacting with to form followed by deprotecting Compound 13 to form wherein Compound 13 is not isolated prior to deprotection and PG is a protecting group. (ii) Coupling Compound 14 with to produce (iii) Without isolating Compound 16, hydrogenating Compound 16 to produce (iv) Without isolating Compound 21, lactamising Compound 21 to produce (v) Converting Compound 18 to and (vi) Coupling Compound 19 or salt thereof, to or salt thereof, wherein the coupling of step (vi) comprises the use of a coupling reagent and a compound selected from: wherein R 5 is either hydrogen, aryl, halogen, C 1-6 alkyl, OC 1-6 alkyl or C 3 -C 8 cycloalkyl, and wherein any of compounds 11, 12, 13, 14, 15, 16. 21 and 18 independently may be provided as salts.
An orthopedic orthosis, consisting of a substantially 2-dimensional flat base having right and left ends, said base having one or more zones extending from said base in a third dimension, in which said base consists of a single seam-free piece obtained by means of an electronic flat-bed knitting machine, in which said zones extending from said base in a third dimension are connected uninterruptedly to said base, characterized in that it is constituted by an orthopedic post-operative knee brace comprising a base having a central mesh zone, a pair of zones (31, 32) extending from said base in a third dimension, joint cover inserts (34, 35) fixed to said base and comprising slots (36, 37) for straps to pass through, and blocking inserts (38, 39) at the respective right and left ends of the knee brace, designed to engage together to adapt and block the knee brace to the leg of a patient at the knee, and in that said base consists of a single seam-free piece obtained by means of an electronic flat-bed knitting machine, in which said central zone is a mesh and said zones (31, 32) with a three-dimensional development are connected uninterruptedly to said central zone.
Production method for forming a deformed cover layer, comprising the following steps: providing a semiconductor substrate comprising a lattice plane that extends in a non-symmetrical manner and such that it is offset at an angle α from at least a first main surface region or a second main surface region of the semiconductor substrate, the first main surface region and the second main surface region extending parallel to each other; starting from the first main surface region, section-by-section anisotropic etching into the semiconductor substrate so as to obtain an etching structure which comprises, in a plane extending perpendicularly to the first main surface region of the semiconductor substrate, two different etching angles (β 1, β 2) relative to the first main surface region; arranging a cover layer on the first main surface region of the semiconductor substrate, so that the cover layer is deformed in the area of the etching structure to lie against the etching structure in at least some sections; and removing, section-by-section, the material of the semiconductor substrate starting from the second main surface region in the area of the deformed cover layer, so that in the semiconductor substrate a window region is formed wherein the cover layer is arranged in a manner that is non-parallel to the first main surface region and wherein the cover layer is exposed. providing a semiconductor substrate comprising a lattice plane that extends in a non-symmetrical manner and such that it is offset at an angle α from at least a first main surface region or a second main surface region of the semiconductor substrate, the first main surface region and the second main surface region extending parallel to each other; starting from the first main surface region, section-by-section anisotropic etching into the semiconductor substrate so as to obtain an etching structure which comprises, in a plane extending perpendicularly to the first main surface region of the semiconductor substrate, two different etching angles (β 1, β 2) relative to the first main surface region; arranging a cover layer on the first main surface region of the semiconductor substrate, so that the cover layer is deformed in the area of the etching structure to lie against the etching structure in at least some sections; and removing, section-by-section, the material of the semiconductor substrate starting from the second main surface region in the area of the deformed cover layer, so that in the semiconductor substrate a window region is formed wherein the cover layer is arranged in a manner that is non-parallel to the first main surface region and wherein the cover layer is exposed.
A data processing method, comprising: sending, by a user equipment, UE, updated metadata; obtaining, by the UE, a code word for broadcasting, wherein the code word comprises a metadata index value corresponding to the updated metadata; and broadcasting, by the UE, the obtained code word. sending, by a user equipment, UE, updated metadata; obtaining, by the UE, a code word for broadcasting, wherein the code word comprises a metadata index value corresponding to the updated metadata; and broadcasting, by the UE, the obtained code word.
A cooking device with at least one chassis and at least one cooking hob (36, 38, 40), wherein: - the chassis includes two side walls, a front wall or front frame and rear wall or rear frame, - each the side wall comprises an upper border, - a bracket is fixed on each upper border, - a protection box forms a lower part of the cooking hob and is detachably arranged or arrangeable on the chassis, - the protection box is clamped or clampable between the brackets and the rear wall or rear frame, - at least two front fixing elements are fixed or fixable on the brackets, - at least two rear fixing elements are detachably fixed or fixable, and - a hob frame is detachably arranged or arrangeable on the front fixing elements and on the rear fixing elements, characterized in, that the upper border of each side wall is formed as a flange, the bracket is detachably fixed or fixable on a front portion of each upper border, the at least two rear fixing elements are detachably fixed or fixable on the rear portions of the upper border, a control panel is detachably fixed or fixable at the brackets, the fixation of the at least two front fixing elements on the brackets is detachable, the bracket includes at least one vertical front tap for supporting a front side of the hob frame, the vertical front taps of the brackets are provided for holding the hob frame along the longitudinal direction, i.e. the direction from the front side to the rear side, while the front fixing elements on the brackets are provided for centring the hob frame along the cross direction, and the rear fixing elements fix the hob frame along the longitudinal direction. - the chassis includes two side walls, a front wall or front frame and rear wall or rear frame, - each the side wall comprises an upper border, - a bracket is fixed on each upper border, - a protection box forms a lower part of the cooking hob and is detachably arranged or arrangeable on the chassis, - the protection box is clamped or clampable between the brackets and the rear wall or rear frame, - at least two front fixing elements are fixed or fixable on the brackets, - at least two rear fixing elements are detachably fixed or fixable, and - a hob frame is detachably arranged or arrangeable on the front fixing elements and on the rear fixing elements,
A method for noise reduction in a robot system, the method comprising: obtaining a gesture to be performed by a robot; receiving incoming audio, the incoming audio including audio from a user and robot noise caused by the robot's performance of the gesture; retrieving, from a gesture library, a noise profile (INM N) associated with the gesture for removing the robot noise caused by the robot's performance of the gesture from the incoming audio, wherein the noise profile associated with the gesture is created using a physics model representative of the noise created by the robot when the robot performs a gesture; and applying the noise profile (INM N) to remove the robot noise from the incoming audio. obtaining a gesture to be performed by a robot; receiving incoming audio, the incoming audio including audio from a user and robot noise caused by the robot's performance of the gesture; retrieving, from a gesture library, a noise profile (INM N) associated with the gesture for removing the robot noise caused by the robot's performance of the gesture from the incoming audio, wherein the noise profile associated with the gesture is created using a physics model representative of the noise created by the robot when the robot performs a gesture; and applying the noise profile (INM N) to remove the robot noise from the incoming audio.
A lubrication system, comprising: a housing defining a bore that extends along a first axis towards an end wall; and a flow restrictor assembly that extends into the bore along the first axis, the system characterized in that the flow restrictor includes: a threaded element defining a plurality of threads that extend from a first threaded element end towards a second threaded element end, and a sleeve disposed about a portion of the plurality of threads, a lubrication flow path being defined between the portion of the plurality of threads and the sleeve. a housing defining a bore that extends along a first axis towards an end wall; and a flow restrictor assembly that extends into the bore along the first axis, the system characterized in that the flow restrictor includes: a threaded element defining a plurality of threads that extend from a first threaded element end towards a second threaded element end, and a sleeve disposed about a portion of the plurality of threads, a lubrication flow path being defined between the portion of the plurality of threads and the sleeve. a threaded element defining a plurality of threads that extend from a first threaded element end towards a second threaded element end, and a sleeve disposed about a portion of the plurality of threads, a lubrication flow path being defined between the portion of the plurality of threads and the sleeve.
A process for preparing an ethylene polymer, the process comprising: polymerizing ethylene and optionally a co-monomer in the presence of a free radical initiator in an autoclave reactor at a pressure ranging from 6.8948 x 10 7 to 3.44738 x 10 8 Pa (10,000 to 50,000 psig) and a temperature ranging from 120 to 340°C, wherein the autoclave reactor comprises a top-head plate, a bottom-head plate, and a vertically oriented, hollow cylindrical body comprising an interior vertical wall; and wherein the autoclave reactor comprises one or more elongated wall baffles whose length extends vertically along the interior vertical wall and which are machined into the inner wall of the reactor cylinder during its formation. polymerizing ethylene and optionally a co-monomer in the presence of a free radical initiator in an autoclave reactor at a pressure ranging from 6.8948 x 10 7 to 3.44738 x 10 8 Pa (10,000 to 50,000 psig) and a temperature ranging from 120 to 340°C, wherein the autoclave reactor comprises a top-head plate, a bottom-head plate, and a vertically oriented, hollow cylindrical body comprising an interior vertical wall; and wherein the autoclave reactor comprises one or more elongated wall baffles whose length extends vertically along the interior vertical wall and which are machined into the inner wall of the reactor cylinder during its formation.
A method, comprising: removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment while said subsea equipment is operatively connected to a subsea equipment installation in a subsea environment; storing said at least said removed portion of said trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 130) that is positioned in said subsea environment, wherein said subsea containment structure (120, 120a, 120b) comprises an adjustable-volume subsea containment structure; disconnecting said subsea equipment from said subsea equipment installation; and retrieving said subsea equipment from said subsea environment. removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment while said subsea equipment is operatively connected to a subsea equipment installation in a subsea environment; storing said at least said removed portion of said trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 130) that is positioned in said subsea environment, wherein said subsea containment structure (120, 120a, 120b) comprises an adjustable-volume subsea containment structure; disconnecting said subsea equipment from said subsea equipment installation; and retrieving said subsea equipment from said subsea environment.
A scroll compressor comprising: a rotor that is stored in a motor casing; a stator that is stored in the motor casing, and drives the rotor to rotate; a rotary shaft that is held by bearings, and rotates integrally with the rotor; and an end bracket through which one end portion of the rotary shaft passes, and which seals the motor casing; characterized by an orbiting scroll that supports the other end portion of the rotary shaft, and orbits as the rotary shaft rotates; a fixed scroll that is disposed facing the orbiting scroll; a suction type cooling fan which is fixed to one end portion of the rotary shaft while being apart by a clearance from the end bracket, and which suctions outside air through a suction port provided in an end surface of a fan cover, the end surface facing the end bracket, and generates cooling wind in the fan cover for cooling the fixed scroll or the orbiting scroll through a duct, as a rotary vane accommodated in the fan cover rotates; and a discharge brush which is fixed to the end bracket facing the cooling fan by a fixing member attached in a radial direction relative to the rotary shaft, and one end of which is in contact with the rotary shaft, in a space secured by the clearance. a rotor that is stored in a motor casing; a stator that is stored in the motor casing, and drives the rotor to rotate; a rotary shaft that is held by bearings, and rotates integrally with the rotor; and an end bracket through which one end portion of the rotary shaft passes, and which seals the motor casing; characterized by an orbiting scroll that supports the other end portion of the rotary shaft, and orbits as the rotary shaft rotates; a fixed scroll that is disposed facing the orbiting scroll; a suction type cooling fan which is fixed to one end portion of the rotary shaft while being apart by a clearance from the end bracket, and which suctions outside air through a suction port provided in an end surface of a fan cover, the end surface facing the end bracket, and generates cooling wind in the fan cover for cooling the fixed scroll or the orbiting scroll through a duct, as a rotary vane accommodated in the fan cover rotates; and a discharge brush which is fixed to the end bracket facing the cooling fan by a fixing member attached in a radial direction relative to the rotary shaft, and one end of which is in contact with the rotary shaft, in a space secured by the clearance.
A cover material for a packaging container for retort sterilization, comprising a multilayer laminate obtained by laminating a base layer, interlayer and sealing layer in that order, the base layer comprising a laminated film obtained by laminating a polyethylene terephthalate film or polybutylene terephthalate film on an aluminum foil, the interlayer comprising an ethylene/propylene block copolymer, an ethylene/propylene random copolymer or high-density polyethylene, wherein the density of said high-density polyethylene according to JIS K7112 is 0.945 to 0.965 g/cm 3, the sealing layer comprising a mixture of high-density polyethylene and an ethylene/propylene random copolymer, wherein the density of said high-density polyethylene according to JIS K7112 is 0.945 to 0.965 g/cm 3, and MFR(190°C) of said high-density polyethylene according to JIS K6922 is 1 to 7 g/10 min, the aluminum foil and the polyethylene terephthalate film or polybutylene terephthalate film in the base layer is laminated using a polyurethane-based adhesive or polyester-based adhesive, the base layer being laminated with the aluminum foil side facing the interlayer, the aluminum foil and interlayer in the base layer being laminated using a polyurethane-based adhesive or a polyester-based adhesive, and the thickness of the aluminum foil being 5 to 40 μm, the thickness of the polyethylene terephthalate film or polybutylene terephthalate film being 6 to 18 μm, the thickness of the interlayer being 10 to 100 μm and the thickness of the sealing layer being 3 to 20 μm, wherein the cover material has a structure of sealing layer / interlayer / adhesive / aluminum foil / adhesive / polyethylene terephthalate film or polybutylene terephthalate film layer, wherein each of the layers is adjacent to the surrounding layers.
Football training apparatus for improving the foot speed and skill of a footballer, the apparatus including a plurality of target assemblies, each target assembly including at least one target, each target including a target member, an alert device and a sensor, the apparatus including a controller in signal communication with each alert device and each sensor, the controller including a sequencer which controls the sequence in which the alert devices are activated, the apparatus being arranged so that in use, one alert device is activated until the respective sensor detects that the respective target member has been hit, whereupon the sequencer will deactivate the one alert device and activate another alert device, characterised in that, in use, the target members are configured to be tapped or kicked by the user, each target assembly being substantially spherical, approximately the size of a standard football, each target assembly including at least two targets, the targets being arranged side by side horizontally.
A compound of formula I or a pharmaceutically acceptable salt thereof in which R 1 represents H, fluoro, chloro, bromo, cyano, a C 1-3 alkyl group optionally substituted by one or more fluoro, or a C 1-2 alkoxy group optionally substituted by one or more fluoro; A represents O or S; R 2 and R 3 independently represent H, fluoro, chloro, bromo, a C 1-4 alkyl group optionally substituted by one or more fluoro, or a C 1-4 alkoxy group optionally substituted by one or more fluoro; provided that R 2 and R 3 are not located meta to each other; R 4 and R 5 independently represent H or a C 1-4 alkyl group; and X and Y independently represent O or CH 2 with the proviso that X and Y are different. R 1 represents H, fluoro, chloro, bromo, cyano, a C 1-3 alkyl group optionally substituted by one or more fluoro, or a C 1-2 alkoxy group optionally substituted by one or more fluoro; A represents O or S; R 2 and R 3 independently represent H, fluoro, chloro, bromo, a C 1-4 alkyl group optionally substituted by one or more fluoro, or a C 1-4 alkoxy group optionally substituted by one or more fluoro; provided that R 2 and R 3 are not located meta to each other; R 4 and R 5 independently represent H or a C 1-4 alkyl group; and X and Y independently represent O or CH 2 with the proviso that X and Y are different.