mhurhangee/ep-ind-claims huggingface dataset:
In a computing environment, a system, comprising: a main memory that is volatile and operable to provide access to data stored thereon; a secondary memory that is nonvolatile and operable to provide access to data stored thereon; one or more processors operable to execute instructions corresponding to a database management system that is operable to manage pages in a database buffer pool in the main and secondary memory and to evict a page based on determining whether the page has accesses corresponding to at least three classifications, the page having accesses corresponding to a first of the classifications if accesses to the page are within a first range of percentiles, the page having accesses corresponding to a second of the classifications if accesses to the page are within a second range of percentiles, and the page having accesses corresponding to a third of the classifications if accesses to the page are within a third range of percentiles, the system characterized by the database management system being further operable to scan metadata of randomly selected pages of the buffer pool to determine the first, second, and third ranges, the metadata including data indicative of a most recent time or times at which each page was accessed. a main memory that is volatile and operable to provide access to data stored thereon; a secondary memory that is nonvolatile and operable to provide access to data stored thereon; one or more processors operable to execute instructions corresponding to a database management system that is operable to manage pages in a database buffer pool in the main and secondary memory and to evict a page based on determining whether the page has accesses corresponding to at least three classifications, the page having accesses corresponding to a first of the classifications if accesses to the page are within a first range of percentiles, the page having accesses corresponding to a second of the classifications if accesses to the page are within a second range of percentiles, and the page having accesses corresponding to a third of the classifications if accesses to the page are within a third range of percentiles, the system characterized by the database management system being further operable to scan metadata of randomly selected pages of the buffer pool to determine the first, second, and third ranges, the metadata including data indicative of a most recent time or times at which each page was accessed.
A composition comprising a recombinant adeno-associated virus expression vector comprising a nucleic acid encoding exogenous NeuroD1 for use in a method of reducing neuroinflammation and/or repairing blood vessels associated with disruption of normal blood flow in the CNS in an individual subject in need thereof, wherein the disruption of normal blood flow in the CNS is due to a disorder selected from the group consisting of: thrombosis, embolism, hemorrhage, concussion, blast, penetration, inflammation, infection, chronic disease mediated restriction of blood vessels and a combination of any two or more thereof, the method comprising: administering a therapeutically effective dose of said composition to an area where normal blood flow has been disrupted.
Flush-mounted LED luminaire (1, 2, 3, 4) for electrical and mechanical connection to a commercially available flush-mounted device box, comprising a device base having a power supply unit/converter, at least one LED module comprising at least one LED, and a connection unit for mains lines, and comprising a luminaire cover having at least one light outlet (19, 20), characterized • in that the device base has a heat sink and the at least one LED module is brought into contact thermally with the heat sink, and • in that the device base has at least one connection device for connecting the at least one LED module comprising at least one LED, wherein the connection device is embodied in the form of one plug connector for contacting electrical contacts of one LED module or a plurality of plug connectors (9, 10) for contacting a plurality of LED modules. • in that the device base has a heat sink and the at least one LED module is brought into contact thermally with the heat sink, and • in that the device base has at least one connection device for connecting the at least one LED module comprising at least one LED, wherein the connection device is embodied in the form of one plug connector for contacting electrical contacts of one LED module or a plurality of plug connectors (9, 10) for contacting a plurality of LED modules.
An interconnection structure comprising: at least three magnetic tunnel junction structures (452, 452a, 452b, 452c) disposed on a substrate, a first magnetic tunnel junction structure of the at least three magnetic tunnel junction structures (452, 452a, 452b, 452c) comprising: a patterned film stack comprising a first ferromagnetic layer, a tunneling barrier layer and a second ferromagnetic layer disposed on and contacting a top surface of a first lower interconnection structure, wherein the first ferromagnetic layer and the second ferromagnetic layer sandwich the tunneling barrier layer; and a patterned hardmask layer disposed on the first ferromagnetic layer, the patterned hardmask layer is configured to form a barrier to etching of the patterned film stack; a spin orbit torque layer having a bottommost surface disposed on and contacting a top surface of the patterned hardmask layer, wherein the SOT layer is electrically conductive; and multiple back end structures (640a, 640b) disposed on the SOT layer. at least three magnetic tunnel junction structures (452, 452a, 452b, 452c) disposed on a substrate, a first magnetic tunnel junction structure of the at least three magnetic tunnel junction structures (452, 452a, 452b, 452c) comprising: a patterned film stack comprising a first ferromagnetic layer, a tunneling barrier layer and a second ferromagnetic layer disposed on and contacting a top surface of a first lower interconnection structure, wherein the first ferromagnetic layer and the second ferromagnetic layer sandwich the tunneling barrier layer; and a patterned hardmask layer disposed on the first ferromagnetic layer, the patterned hardmask layer is configured to form a barrier to etching of the patterned film stack; a patterned film stack comprising a first ferromagnetic layer, a tunneling barrier layer and a second ferromagnetic layer disposed on and contacting a top surface of a first lower interconnection structure, wherein the first ferromagnetic layer and the second ferromagnetic layer sandwich the tunneling barrier layer; and a patterned hardmask layer disposed on the first ferromagnetic layer, the patterned hardmask layer is configured to form a barrier to etching of the patterned film stack; a spin orbit torque layer having a bottommost surface disposed on and contacting a top surface of the patterned hardmask layer, wherein the SOT layer is electrically conductive; and multiple back end structures (640a, 640b) disposed on the SOT layer.
Energy storage device for generating an n-phase supply voltage, wherein n ≥ 1, comprising: n energy supply branches which are connected in parallel and which are each coupled to at least one output connection (1a, 1b, 1c) of the energy storage device, wherein each of the energy supply branches has a multiplicity of energy storage modules which are connected in series and which each comprise: an energy storage cell module, which has at least one energy storage cell (5a, 5k), and a coupling device comprising first coupling elements (7a, 7b, 7c, 7d), which are designed to switch the energy storage cell module selectively into the respective energy supply branch or to bypass said energy storage cell module; and wherein at least one of the energy supply branches has at least one second coupling element, which is coupled in each case between output connections (5m, 5p) of adjacent energy storage cell modules in the at least one energy supply branch, and which is designed to switch the coupled energy storage cell modules in parallel with one another into the respective energy supply branch. n energy supply branches which are connected in parallel and which are each coupled to at least one output connection (1a, 1b, 1c) of the energy storage device, wherein each of the energy supply branches has a multiplicity of energy storage modules which are connected in series and which each comprise: an energy storage cell module, which has at least one energy storage cell (5a, 5k), and a coupling device comprising first coupling elements (7a, 7b, 7c, 7d), which are designed to switch the energy storage cell module selectively into the respective energy supply branch or to bypass said energy storage cell module; and an energy storage cell module, which has at least one energy storage cell (5a, 5k), and a coupling device comprising first coupling elements (7a, 7b, 7c, 7d), which are designed to switch the energy storage cell module selectively into the respective energy supply branch or to bypass said energy storage cell module; and
Polymerization process for the synthesis of vinyl aromatic polymers, in which the sequence of monomers in the chain and the linear, branched soluble, or crosslinked insoluble structure, with reactive or different polarity functions, are controlled; which comprises the step of polymerizing vinyl aromatic monomers by means of an Atom Transfer Radical Polymerization (ATRP) reaction with an Activator ReGenerated by Electron Transfer (ARGET), the reaction being carried out at a temperature comprised between 25°C and 110°C in an inert gas atmosphere in the presence of a complex catalyst containing a cupric halide and a multidentate amine ligand, feeding to the reaction an organic initiator having two geminal halogens, an alkali metal (bi)carbonate, a solvent pair of an aliphatic alcohol and an acetic ester of the same aliphatic alcohol and possibly ascorbic acid, provided that no initiator is used with three or more active halogens, or polyvinyl monomers or inimers.
A valve of the ball-valve type for liquid with a valve housing defining a valve chamber connecting an inlet to an outlet and with a valve obturator movably located in the valve chamber at the inlet end of the valve chamber, which valve includes a valve seat cooperating with the valve obturator and further includes a first throttling plate, which throttling plate has an opening there through, which opening determines the flow capacity and the flow characteristic of the valve, which valve obturator includes a spherically shaped outer surface cooperating with said seat and is rotatable around an axis through the centre defined by radius of the spherical surface of the valve obturator, the throttling plate is a component that retains the valve seat in the valve, where the throttling plate has the dual function of throttling the liquid and to act as cover plate for retaining the valve seat in position, characterized in that the throttling plate includes an outer annular ring retaining the valve seat by means of the annular ring being mounted by screws to the valve housing and that the throttling plate includes at least one flange section extending radially inwardly from the annular ring, which flange section is located-at a distance (d) from the outer spherical surface of the valve obturator, wherein said distance (d) is at least 5 % of the radius of said spherically shaped surface and in the range of 5 - 20 mm.
A pharmaceutical composition, comprising: an antineoplastic chemotherapeutic encapsulated in ceramide anionic liposomes, wherein the liposomes comprise at least one pegylated neutral lipid, wherein the total amount of pegylated neutral lipid is an amount in the range of 5-20 Molar percent, inclusive, and wherein at least half of the amount of included modified neutrallipid is N-Octanoyl-Sphingosine-1- succinyl(methoxy(polyethylene)glycol)750 (PEG C8); at least one anionic lipid, wherein the total amount of anionic lipid is an amount in the range of 5-15 Molar percent, inclusive; one or more ceramides selected from C4 ceramide, C6 ceramide, C8 ceramide, C 10 ceramide, C 12 ceramide, C 14 ceramide, C 16 ceramide and C 18 ceramide, in an amount in the range of 1- 40 Molar percent, inclusive; and cationic or neutral lipids, with the proviso that the resulting ceramide anionic liposomes have a net negative charge at physiological pH. an antineoplastic chemotherapeutic encapsulated in ceramide anionic liposomes, wherein the liposomes comprise at least one pegylated neutral lipid, wherein the total amount of pegylated neutral lipid is an amount in the range of 5-20 Molar percent, inclusive, and wherein at least half of the amount of included modified neutrallipid is N-Octanoyl-Sphingosine-1- succinyl(methoxy(polyethylene)glycol)750 (PEG C8); at least one anionic lipid, wherein the total amount of anionic lipid is an amount in the range of 5-15 Molar percent, inclusive; one or more ceramides selected from C4 ceramide, C6 ceramide, C8 ceramide, C 10 ceramide, C 12 ceramide, C 14 ceramide, C 16 ceramide and C 18 ceramide, in an amount in the range of 1- 40 Molar percent, inclusive; and cationic or neutral lipids, with the proviso that the resulting ceramide anionic liposomes have a net negative charge at physiological pH.
A spectroscopy module comprising: a light-transmitting body portion having a front surface and a rear surface, the front surface defining a predetermined plane; a spectroscopic portion for dispersing light made incident through a front surface of the body portion and into the body portion; the spectroscopic portion being formed at the rear surface of the body portion and being further configured to reflect the light incident at the predetermined plane of the front surface; and a light detecting element supported on the front surface of the body portion, to detect the light dispersed and reflected by the spectroscopic portion; wherein a light absorbing layer having a first light-passing hole through which light advancing to the spectroscopic portion passes and a second light-passing hole through which light advancing to the light detecting element passes, is formed on the front surface of the body portion; characterized by: wiring electrically connected to the light detecting element, the wiring being formed either upon the front surface of the body portion or upon a front surface of the light absorbing layer, the front surface being opposite to the front surface of the body portion; the wiring including a first pad portion, a second pad portion, and a connection portion, the first pad portion being electrically connected to the light detecting element and the second pad portion being electrically connected to the first pad portion via the connection portion. wiring electrically connected to the light detecting element, the wiring being formed either upon the front surface of the body portion or upon a front surface of the light absorbing layer, the front surface being opposite to the front surface of the body portion; the wiring including a first pad portion, a second pad portion, and a connection portion, the first pad portion being electrically connected to the light detecting element and the second pad portion being electrically connected to the first pad portion via the connection portion.
A method for evaluating a tumor comprising determining a relative level of malignant cells that express at least one component of facilitates chromatin transcription complex (FACT) in a human subject tumor specimen or cells cultured therefrom, preferably wherein the tumor specimen is a biopsy selected from a frozen tumor tissue specimen, cultured cells, circulating tumor cells, and a formalin-fixed paraffin-embedded tumor tissue specimen, wherein the method further comprises the step of classifying the subject into a high or low risk group based on the presence, absence, or level of at least one component of FACT, preferably wherein: a) the high or low risk classification is predictive of a positive response to and/or benefit from neoadjuvant chemotherapy or a non-responsiveness to and/or lack of benefit from neoadjuvant chemotherapy; b) the high or low risk classification is predictive of a positive response to and/or benefit from adjuvant chemotherapy or a non-responsiveness to and/or lack of benefit from adjuvant chemotherapy; c) the high risk classification comprises a high level of cancer aggressiveness, wherein the aggressiveness is characterizable by one or more of a high tumor grade, low overall survival, high probability of metastasis, and the presence of a tumor marker indicative of aggressiveness; d) the low risk classification comprises a low level of cancer aggressiveness, wherein the aggressiveness is characterizable by one or more of a low tumor grade, high overall survival, low probability of metastasis, and the absence and/or reduction of a tumor marker indicative of aggressiveness; e) the low risk classification is indicative of withholding of neoadjuvant therapy; or f) the low risk classification is indicative of withholding of adjuvant therapy. a) the high or low risk classification is predictive of a positive response to and/or benefit from neoadjuvant chemotherapy or a non-responsiveness to and/or lack of benefit from neoadjuvant chemotherapy; b) the high or low risk classification is predictive of a positive response to and/or benefit from adjuvant chemotherapy or a non-responsiveness to and/or lack of benefit from adjuvant chemotherapy; c) the high risk classification comprises a high level of cancer aggressiveness, wherein the aggressiveness is characterizable by one or more of a high tumor grade, low overall survival, high probability of metastasis, and the presence of a tumor marker indicative of aggressiveness; d) the low risk classification comprises a low level of cancer aggressiveness, wherein the aggressiveness is characterizable by one or more of a low tumor grade, high overall survival, low probability of metastasis, and the absence and/or reduction of a tumor marker indicative of aggressiveness; e) the low risk classification is indicative of withholding of neoadjuvant therapy; or f) the low risk classification is indicative of withholding of adjuvant therapy.
A computer-implemented method for determining hydrocarbon accumulations in a subsurface structure of a reservoir, wherein the subsurface structure includes a plurality of grid cells, the method comprising: identifying, by a hardware processor, one of grid cells neighboring an accumulation as a recent back-filled grid cell, wherein each of the grid cells neighboring the accumulation are represented as a node in a binomial min-heap data structure; setting, by the hardware processor, an oil phase potential of identified grid cell as an accumulation potential of the accumulation; comparing, by the hardware processor, oil phase potentials of grid cells neighboring the recent back-filled grid cell with the accumulation potential of the accumulation, wherein the oil phase potential of each of the grid cells neighboring the recent back-filled grid cell is stored as a key in the node corresponding to the respective grid cell; ending, by the hardware processor, the back-filling process, if there is a neighboring cell having a less oil phase potential than the accumulation potential of the accumulation; selecting, by the hardware processor, among the grid cells neighboring the accumulation, a grid cell having a least oil phase potential as a next back-filled grid cell, if none of the grid cells neighboring the accumulation has a less oil phase potential than the oil phase potential of the recent back-filled grid cell; and updating, by the hardware processor, the accumulation potential of the accumulation based on the oil phase potential of the selected grid cell. identifying, by a hardware processor, one of grid cells neighboring an accumulation as a recent back-filled grid cell, wherein each of the grid cells neighboring the accumulation are represented as a node in a binomial min-heap data structure; setting, by the hardware processor, an oil phase potential of identified grid cell as an accumulation potential of the accumulation; comparing, by the hardware processor, oil phase potentials of grid cells neighboring the recent back-filled grid cell with the accumulation potential of the accumulation, wherein the oil phase potential of each of the grid cells neighboring the recent back-filled grid cell is stored as a key in the node corresponding to the respective grid cell; ending, by the hardware processor, the back-filling process, if there is a neighboring cell having a less oil phase potential than the accumulation potential of the accumulation; selecting, by the hardware processor, among the grid cells neighboring the accumulation, a grid cell having a least oil phase potential as a next back-filled grid cell, if none of the grid cells neighboring the accumulation has a less oil phase potential than the oil phase potential of the recent back-filled grid cell; and updating, by the hardware processor, the accumulation potential of the accumulation based on the oil phase potential of the selected grid cell.
An electrolyzed liquid generator, comprising: an electrolytic part having a stacked body in which a conductive film is stacked to be interposed between a cathode and an anode, the electrolytic part being configured to electrolyze a liquid; and a housing in which the electrolytic part is disposed, wherein the housing includes a channel having an inlet port into which a liquid supplied to the electrolytic part flows and an outlet port from which an electrolyzed liquid generated in the electrolytic part flows out, and having a liquid flow direction in a direction intersecting a stacking direction of the stacked body, the electrolytic part includes a groove opening to the channel and having an interface between the conductive film and the cathode and an interface between the conductive film and the anode, the interfaces (58, 57) at least partially being exposed, characterized in that the electrolyzed liquid generator has a space between at least one of an outer periphery of the cathode and an outer periphery of the anode, and an inner surface of the housing when viewed along the liquid flow direction, wherein the outer periphery of the cathode is a side surface of the cathode and the outer periphery of the anode is a side surface of the anode. an electrolytic part having a stacked body in which a conductive film is stacked to be interposed between a cathode and an anode, the electrolytic part being configured to electrolyze a liquid; and a housing in which the electrolytic part is disposed, wherein the housing includes a channel having an inlet port into which a liquid supplied to the electrolytic part flows and an outlet port from which an electrolyzed liquid generated in the electrolytic part flows out, and having a liquid flow direction in a direction intersecting a stacking direction of the stacked body, the electrolytic part includes a groove opening to the channel and having an interface between the conductive film and the cathode and an interface between the conductive film and the anode, the interfaces (58, 57) at least partially being exposed, characterized in that the electrolyzed liquid generator has a space between at least one of an outer periphery of the cathode and an outer periphery of the anode, and an inner surface of the housing when viewed along the liquid flow direction, wherein the outer periphery of the cathode is a side surface of the cathode and the outer periphery of the anode is a side surface of the anode.