mhurhangee/ep-ind-claims huggingface dataset:
A method for purifying an erythropoietin analog having an isoelectric point below 4, which is a novel erythropoiesis-stimulating protein (NESP) having five N-linked sugar chains comprising: (a) Obtaining a pretreated solution by removing animal cells from a culture solution of the animal cells, wherein the animal cells express the erythropoietin analog having an isoelectric point below 4; (b) Obtaining a first fraction comprising the erythropoietin analog by subjecting the pretreated solution to first anion exchange chromatography, wherein a buffer of pH below 4.0 is used as a washing buffer in the first anion exchange chromatography; (c) Obtaining a second fraction comprising the erythropoietin analog by subjecting the first fraction to hydroxyapatite chromatography; and (d) Obtaining a third fraction comprising the erythropoietin analog by subjecting the second fraction to second anion exchange chromatography, wherein a buffer of pH 2.0-4.0 is used as a washing buffer in the second anion exchange chromatography. (a) Obtaining a pretreated solution by removing animal cells from a culture solution of the animal cells, wherein the animal cells express the erythropoietin analog having an isoelectric point below 4; (b) Obtaining a first fraction comprising the erythropoietin analog by subjecting the pretreated solution to first anion exchange chromatography, wherein a buffer of pH below 4.0 is used as a washing buffer in the first anion exchange chromatography; (c) Obtaining a second fraction comprising the erythropoietin analog by subjecting the first fraction to hydroxyapatite chromatography; and (d) Obtaining a third fraction comprising the erythropoietin analog by subjecting the second fraction to second anion exchange chromatography, wherein a buffer of pH 2.0-4.0 is used as a washing buffer in the second anion exchange chromatography.
Contact arm assembly for a high-voltage switchgear with at least two contact arms which are arranged in pairs and so that they can move relative to each other via at least one pivot and which each comprise a contact arm upper part and a contact arm lower part, wherein the contact arm upper part has in each case at least one recess which is designed for receiving a contact element, characterized in that the respective recess of a contact arm upper part is formed in the form of a slot between at least two rectangular profile bars which are fastened to each other via spacer elements so that they are spaced apart from each other, in particular rectangular profile bars with rounded corners and edges, and wherein at least one contact element, in particular a T-shaped one, is introduced at least partially into the recess between the profile bars, is in mechanical and electrical contact with the profile bars.
Device for use in diagnosing skin and/or scalp conditions comprising a viewing port, illumination units, wherein each illumination unit comprises - an emitter for radiating a light beam comprising a carrier on which UV radiating LEDs (18, 20) are mounted; and - an optical member comprising a reflector for directing and widening the light beam radiated from the emitter, wherein each reflector of the illumination units comprises a light diffusing element for diffusing the light beam, wherein the light diffusing element comprises a structure spread over a surface of the optical member to direct the emitted rays towards the surface under observation with a wide beam and in this way minimize the formation of shadows and shading patterns, wherein the device further comprises a light shield (10, 11, 12) to block off environmental light such that diagnosing can be based on observations as a result of the light propagating in the beam. - an emitter for radiating a light beam comprising a carrier on which UV radiating LEDs (18, 20) are mounted; and - an optical member comprising a reflector for directing and widening the light beam radiated from the emitter,
A silicon single crystal growth method, which uses a Czochralski process for growing a silicon single crystal through a solid-liquid interface by dipping a seed into a silicon melt received in a quartz crucible and pulling up the seed while rotating the quartz crucible and applying a strong horizontal magnetic field, wherein the seed is pulled up while the quartz crucible is rotated with a rate between 0.6 rpm and 1.5 rpm, wherein the quartz crucible is rotated with a rate between 0.6 rpm and 0.8 rpm at an initial stage of a body of the silicon single crystal to grow a single crystal with oxygen concentration between 10.6 ppma and 12.8 ppma; wherein a rotation rate of the quartz crucible is gradually increased to minimize a width of change in oxygen concentration according to single crystal growth length, and the crucible rotation rate ranges from 0.7 rpm to 1.3 rpm to compensate for reduction of oxygen concentration in the ingot length between 900 mm and 1300 mm.
A method at a local computing device for providing real-time media optimization, the method comprising: establishing a session with a remote computing device, including establishing a hop between a client running on the local computing device and an application running on a server, the established hop being in a server path (225, 230), and establishing a media path being a path established directly with the remote computing device and not involving the server; exchanging, during the session, non-real-time media data with the remote computing device over the server path, wherein exchanging the non-real-time media data with the remote computing device over the server path comprises passing the non-real-time data through the server in the server path; exchanging, during the session, real-time media data with the remote computing device over the media path; and synchronizing the real-time media data from the media path and the non-real-time media data from the server path, wherein synchronizing comprises: receiving, from the server, a position and shape of a video region which is related to the real-time media data; and rendering the real-time media data exchanged from the media path on a proxy window, the proxy window tracking the position and the shape of the video region received from the server. establishing a session with a remote computing device, including establishing a hop between a client running on the local computing device and an application running on a server, the established hop being in a server path (225, 230), and establishing a media path being a path established directly with the remote computing device and not involving the server; exchanging, during the session, non-real-time media data with the remote computing device over the server path, wherein exchanging the non-real-time media data with the remote computing device over the server path comprises passing the non-real-time data through the server in the server path; exchanging, during the session, real-time media data with the remote computing device over the media path; and synchronizing the real-time media data from the media path and the non-real-time media data from the server path, wherein synchronizing comprises: receiving, from the server, a position and shape of a video region which is related to the real-time media data; and rendering the real-time media data exchanged from the media path on a proxy window, the proxy window tracking the position and the shape of the video region received from the server. receiving, from the server, a position and shape of a video region which is related to the real-time media data; and rendering the real-time media data exchanged from the media path on a proxy window, the proxy window tracking the position and the shape of the video region received from the server.
A method for managing notifications in an electronic device, the method comprising: displaying at least one notification message, associated with a first application, in a notification area of the electronic device, without opening the first application; detecting a first user input performed on the at least one notification message displayed in the notification area; and displaying at least one graphical object representing at least one data item corresponding to the at least one notification message within the notification area, at least a part of the at least one data item being associated with a second application (412a, 412b, 412c) different from the first application, wherein the graphical object is displayed without opening the second application. displaying at least one notification message, associated with a first application, in a notification area of the electronic device, without opening the first application; detecting a first user input performed on the at least one notification message displayed in the notification area; and displaying at least one graphical object representing at least one data item corresponding to the at least one notification message within the notification area, at least a part of the at least one data item being associated with a second application (412a, 412b, 412c) different from the first application, wherein the graphical object is displayed without opening the second application.
An isolated antibody or antigen-binding portion thereof that specifically binds to a soluble Major Histocompatibility Complex class I chain-related (sMIC) polypeptide, the antibody or antigen-binding portion thereof comprising heavy and light chain complimentarity determining regions (CDRs) of: a light chain CDR1 having the amino acid sequence of SEQ ID NO: 9; a light chain CDR2 having the amino acid sequence of SEQ ID NO: 10; a light chain CDR3 having the amino acid sequence of SEQ ID NO: 11; a heavy chain CDR1 having the amino acid sequence of SEQ ID NO: 12; a heavy chain CDR2 having the amino acid sequence of SEQ ID NO: 13; and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO: 14. a light chain CDR1 having the amino acid sequence of SEQ ID NO: 9; a light chain CDR2 having the amino acid sequence of SEQ ID NO: 10; a light chain CDR3 having the amino acid sequence of SEQ ID NO: 11; a heavy chain CDR1 having the amino acid sequence of SEQ ID NO: 12; a heavy chain CDR2 having the amino acid sequence of SEQ ID NO: 13; and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO: 14.
A method, comprising: receiving first input comprising real-world data from a traffic accident database and related to expected states of a vehicle and another vehicle at impact event initiation with positions, orientations, and velocities for a plurality of cases as parameters used for impact event evaluation; receiving second input related to expected vehicle occupant position and position transfer during a pre-impact event maneuver for at least a portion of the plurality of cases; and simulating an impact event using both the first input and the second input to predict a combined effect from a collision avoidance feature and an injury prevention feature. receiving first input comprising real-world data from a traffic accident database and related to expected states of a vehicle and another vehicle at impact event initiation with positions, orientations, and velocities for a plurality of cases as parameters used for impact event evaluation; receiving second input related to expected vehicle occupant position and position transfer during a pre-impact event maneuver for at least a portion of the plurality of cases; and simulating an impact event using both the first input and the second input to predict a combined effect from a collision avoidance feature and an injury prevention feature.
Heterocyclic nitrogen-containing purine derivative of the general formula I, wherein R are independently selected from the group consisting of H, Cl, Br, methyl, OH, and methoxy, and n = 1 or 2; R 1 is independently on each occurrence H or methyl, or R1 is not present; A is independently on each occurrence selected from the group consisting of C, N, O, S; a, b, c, d are, independently of each other, an integer selected from 1, 2, 3; provided that the compound of formula I is not 2,6-dimorpholino-9-benzylpurine; and the pharmaceutically acceptable salts thereof, in particular salts with alkali metals, ammonium or amines, or addition salts with acids. R are independently selected from the group consisting of H, Cl, Br, methyl, OH, and methoxy, and n = 1 or 2; R 1 is independently on each occurrence H or methyl, or R1 is not present; A is independently on each occurrence selected from the group consisting of C, N, O, S; a, b, c, d are, independently of each other, an integer selected from 1, 2, 3; provided that the compound of formula I is not 2,6-dimorpholino-9-benzylpurine;
Use of an engine oil, having a kinematic viscosity at 100°C according to standard ASTM D445 of 16 to 27 cSt, comprising 0.5 to 10 wt% of at least one ester (a) selected from glycerol mono- or di-oleate, glycerol mono- or di-stearate or glycerol mono- or di-isostearate, for reducing wear of the bearings in internal combustion engines of vehicles with hybrid engines, the maximum torque of which, measured between 1000 and 3000 rpm, is higher than 1000 N·m.
A device configured for use within the duodenum of a human, comprising: a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and a porous flow reduction element positioned along the spine having a surrounding wall defining a hollow interior, characterized in that the wall of the flow reduction element has a variable porosity along its length such that the wall at a proximal end of the flow reduction element is more porous than the wall at a distal end of the flow reduction element and in that the variable porosity of the wall of the flow reduction element is such that a portion of a flow over the proximal end of the flow reduction element can flow into an interior portion of the flow reduction element. a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and a porous flow reduction element positioned along the spine having a surrounding wall defining a hollow interior, characterized in that the wall of the flow reduction element has a variable porosity along its length such that the wall at a proximal end of the flow reduction element is more porous than the wall at a distal end of the flow reduction element and in that the variable porosity of the wall of the flow reduction element is such that a portion of a flow over the proximal end of the flow reduction element can flow into an interior portion of the flow reduction element.
A method of making polyurethane or polyurethane urea strands containing siloxane in the polyurethane or polyurethane urea backbone comprising the following steps: (a) reacting a macroglycol with a diisocyanate to form a prepolymer; (b) reacting the prepolymer with a diamine to form a spinning solution; (c) dry spinning the spinning solution to form polyurethane or polyurethane urea strands, wherein: i. A mixture of a diol-polydimethylsiloxane and a macroglycol are reacted with the diisocyanate in step (a); ii. a diamine-polydimethylsiloxane is reacted with the prepolymer prior to the reaction of the prepolymer with the diamine in step (b); or iii. a diamine-polydimethylsiloxane is reacted at the same time as the prepolymer and diamine in step (b), and wherein the polyurethane or polyurethane urea strands comprise less than or equal to 6% of siloxane by weight based on the weight of the polyurethane or polyurethane urea strands. (a) reacting a macroglycol with a diisocyanate to form a prepolymer; (b) reacting the prepolymer with a diamine to form a spinning solution; (c) dry spinning the spinning solution to form polyurethane or polyurethane urea strands, i. A mixture of a diol-polydimethylsiloxane and a macroglycol are reacted with the diisocyanate in step (a); ii. a diamine-polydimethylsiloxane is reacted with the prepolymer prior to the reaction of the prepolymer with the diamine in step (b); or iii. a diamine-polydimethylsiloxane is reacted at the same time as the prepolymer and diamine in step (b), and
Connection device, comprising a tubular body provided on the inside with connection means (106, 107, 108) for attaching thereto an end portion of a tube and on the outside with a threaded surface portion having a nominal diameter (dn) corresponding to that (Dn) of an internal thread of a circuit element so as to be able to be screwed into the latter, the body also being provided with sealing means (109, 111) to seal the connection of the tube end portion to the circuit element, characterized in that the threaded surface portion extends over a first end section of the body, said first end section of the body including substantially axial slots delimiting between them arms elastically deformable between a state of rest in which the arms delimit a nominal thread diameter (dn) substantially equal to the nominal diameter (Dn) of the internal thread and a deformed state in which the nominal thread diameter (dn) is smaller than the inside diameter (Di) of the internal thread, and in that a tubular latch is mounted in the body to slide axially between an unlatching position in which the latch has a first end section released from the arms to leave them free to deform and a latching position in which the first end section of the latch faces the arms to oppose their deformation, the tube end portion coming to bear against the latch during its insertion into the body to bring it into said latching position.
A method for producing a 3D item by means of fused deposition modelling using a fused deposition modeling 3D printer comprising a printer nozzle, the method comprising a 3D printing stage comprising depositing an extrudate comprising 3D printable material, to provide the 3D item comprising 3D printed material, wherein the 3D printing stage comprises a thread formation stage comprising: (i) depositing at a substrate at a first position first 3D printable material to provide a start support element of first 3D printed material, wherein the substrate is selected from a receiver item and already 3D printed material on the receiver item; characterized by (ii) changing during a transport stage the horizontal position of the nozzle relative to the first position to a second position, while during the transport stage pulling with the printer nozzle first 3D printable material away from the start support element and while reducing a flow of first 3D printable material from the nozzle such that a thread of first 3D printed material is formed; and (iii) depositing at the substrate at the second position first 3D printable material to provide an end support element of first 3D printed material for the thread, wherein the start support element and the end support element have a height and a width, wherein the thread has a thread thickness and a thread length, wherein D1/H ≤ 0.5 and D1/W ≤ 0.5, wherein the thread thickness is selected from the range of 10-200 μm, and wherein the thread length is selected from the range of 1-20 mm. (i) depositing at a substrate at a first position first 3D printable material to provide a start support element of first 3D printed material, wherein the substrate is selected from a receiver item and already 3D printed material on the receiver item; characterized by (ii) changing during a transport stage the horizontal position of the nozzle relative to the first position to a second position, while during the transport stage pulling with the printer nozzle first 3D printable material away from the start support element and while reducing a flow of first 3D printable material from the nozzle such that a thread of first 3D printed material is formed; and (iii) depositing at the substrate at the second position first 3D printable material to provide an end support element of first 3D printed material for the thread, wherein the start support element and the end support element have a height and a width, wherein the thread has a thread thickness and a thread length, wherein D1/H ≤ 0.5 and D1/W ≤ 0.5, wherein the thread thickness is selected from the range of 10-200 μm, and wherein the thread length is selected from the range of 1-20 mm. wherein the start support element and the end support element have a height and a width, wherein the thread has a thread thickness and a thread length, wherein D1/H ≤ 0.5 and D1/W ≤ 0.5, wherein the thread thickness is selected from the range of 10-200 μm, and wherein the thread length is selected from the range of 1-20 mm.
A method (100, 300, 400) for selecting a physical layer identifier for use in a basestation in a mobile communications network, wherein the network comprises a plurality of other basestations, the method comprising: receiving (110, 480) a set of identifiers available for use by basestations within the network, wherein the set is partitioned into a first subset of identifiers reserved for temporary use and a second subset of identifiers reserved for final use; checking for network demand on at least one of the subsets of available identifiers, wherein checking for network demand on the first subset comprises analysing a delay period for availability of a temporary identifier on receipt of a report from a basestation and wherein checking for network demand on the second subset comprises analysing user equipment, UE, measurement statistics indicating degrees of freedom experienced in assigning identifiers from the second subset; adjusting the partition between the subsets according to the network demand; assigning (120, 490) a temporary identifier to the basestation; receiving (140, 340) reports from UEs connected to the basestation, wherein each of the reports indicates identifiers in use by basestations detected by the connected UEs; assigning (160, 368) a final identifier to the basestation from the second subset, wherein the final identifier is different from the temporary identifier. receiving (110, 480) a set of identifiers available for use by basestations within the network, wherein the set is partitioned into a first subset of identifiers reserved for temporary use and a second subset of identifiers reserved for final use; checking for network demand on at least one of the subsets of available identifiers, wherein checking for network demand on the first subset comprises analysing a delay period for availability of a temporary identifier on receipt of a report from a basestation and wherein checking for network demand on the second subset comprises analysing user equipment, UE, measurement statistics indicating degrees of freedom experienced in assigning identifiers from the second subset; adjusting the partition between the subsets according to the network demand; assigning (120, 490) a temporary identifier to the basestation; receiving (140, 340) reports from UEs connected to the basestation, wherein each of the reports indicates identifiers in use by basestations detected by the connected UEs; assigning (160, 368) a final identifier to the basestation from the second subset, wherein the final identifier is different from the temporary identifier.
Method for manufacturing a hardened sheet metal profile (1; 9, 10) from a blank (2; 11), wherein a section (5; 14) delimited by at least one cutting edge (4; 12, 13) is cut out of the blank (2; 11), the cutting depth (t v) being less than half the thickness of the material (s) of the blank (2; 11) and when being cut the material of the blank (2; 11) in the cut out area (5; 14) is pushed out of the plane of the blank (2; 11) in one direction and the blank (2; 11) is then hot formed in a press tool and is hardened at least partially and the cut out section (5; 14) is pushed out at the cutting edge (4; 12, 13) after hot forming, the cutting and pushing out of the section (5; 14) being performed in opposite directions.