mhurhangee/ep-ind-claims huggingface dataset:
Polypeptide comprising a first and a second immunoglobulin single variable domain, wherein - said first ISV has high affinity for/binds to the constant domain of the T cell receptor present on a T cell; - said second ISV has high affinity for/binds to a first antigen on a target cell; wherein said first antigen is different from said TCR; and wherein said target cell is different from said T cell, and wherein said first ISV essentially consists of 4 framework regions (FR1 to FR4, respectively) and 3 complementarity determining regions (CDR1 to CDR3, respectively), in which: (i) CDR1 is chosen from the group consisting of: (a) SEQ ID NOs: 119-133; or (b) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 123 or with any of SEQ ID NOs: 119-133; and/or (ii) CDR2 is chosen from the group consisting of: (c) SEQ ID NOs: 134-163; or (d) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 153 or with any of SEQ ID NOs: 134-163; and/or (iii) CDR3 is chosen from the group consisting of: (e) SEQ ID NOs: 164-174; or (f) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 170 or with any of SEQ ID NOs: 164-174. - said first ISV has high affinity for/binds to the constant domain of the T cell receptor present on a T cell; - said second ISV has high affinity for/binds to a first antigen on a target cell; (i) CDR1 is chosen from the group consisting of: (a) SEQ ID NOs: 119-133; or (b) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 123 or with any of SEQ ID NOs: 119-133; and/or (a) SEQ ID NOs: 119-133; or (b) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 123 or with any of SEQ ID NOs: 119-133; and/or (ii) CDR2 is chosen from the group consisting of: (c) SEQ ID NOs: 134-163; or (d) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 153 or with any of SEQ ID NOs: 134-163; and/or (c) SEQ ID NOs: 134-163; or (d) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 153 or with any of SEQ ID NOs: 134-163; and/or (iii) CDR3 is chosen from the group consisting of: (e) SEQ ID NOs: 164-174; or (f) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 170 or with any of SEQ ID NOs: 164-174. (e) SEQ ID NOs: 164-174; or (f) amino acid sequences that have 4, 3, 2, or 1 amino acid(s) difference with the amino acid sequence of SEQ ID NO: 170 or with any of SEQ ID NOs: 164-174.
A method of teaching a robotic cleaning device a perimeter of an area of interest, comprising the steps of: - positioning the robotic cleaning device so that an obstacle detecting device of the robotic cleaning device can monitor at least part of the area; - controlling the obstacle detecting device of the robotic cleaning device to follow and continuously record a position of an object, while the object is moving along the perimeter of the area of interest; and - creating positional data of the perimeter from the continuous recordings of the positions of the object. - positioning the robotic cleaning device so that an obstacle detecting device of the robotic cleaning device can monitor at least part of the area; - controlling the obstacle detecting device of the robotic cleaning device to follow and continuously record a position of an object, while the object is moving along the perimeter of the area of interest; and - creating positional data of the perimeter from the continuous recordings of the positions of the object.
Compression aid for compressing a puncture site of a patient, wherein the compression aid comprises a peripheral band whose circumference can be adjusted, wherein a constant force spring is arranged in the peripheral band and an indicator is located on the constant force spring, preferably on the outer side of the constant force spring, and is configured to indicate the deflection of the constant force spring and to indicate the range of the constant force to the user.
A device for fastening a latch wire of a seat portion of a vehicle seat to a floor pan of the latter, said device including a housing designed to be solidly connected to said floor pan and housing a locking lug that is rotatably mounted and intended to lock said latch wire in order to prevent the vertical movement thereof, characterized in that said housing includes, behind said locking lug, a retaining wall suitable for the passage of the latter and defining a transverse abutment that can block a longitudinal movement toward the rear of said vehicle of at least a substantially vertical part of said latch wire when the latter is subjected to a force that drives it towards the rear of said vehicle.
Pump unit (14, 30) for conveying a reduction liquid, in particular for conveying a urea-water solution for the reduction of nitrogen oxides in an exhaust-gas flow of an internal combustion engine, having a housing cover, having a housing upper part and having a housing lower part, wherein, between the housing cover and the housing upper part, there is held a diaphragm which can be actuated by means of a drive unit, and a first and a second connection chamber (60, 62) are provided in the housing lower part, wherein the conveying direction is reversible by means of an integrated valve unit, in particular by means of a 4/2-way valve, characterized in that at least two check valves (52, 54) are arranged in the housing upper part and at least two check valves (56, 58) are arranged in the housing lower part, wherein the check valves (52, 54) in the housing upper part are arranged so as to act oppositely to the check valves (56, 58) in the housing lower part.
An endoscope objective lens arrangement, comprising, in order from a distal end of an endoscope: - a cover glass; - a first lens that is plano-concave, which is the distal-most lens in the arrangement, with its concave surface facing the distal end of the endoscope; - an aperture diaphragm; - a second lens that is plano-convex, with its convex surface facing a proximal end of the endoscope; - a third lens and a fourth lens adapted to form a doublet wherein the focal points of the first lens, the second lens, the third lens, and the fourth lens are disposed along a single optical axis. - a cover glass; - a first lens that is plano-concave, which is the distal-most lens in the arrangement, with its concave surface facing the distal end of the endoscope; - an aperture diaphragm; - a second lens that is plano-convex, with its convex surface facing a proximal end of the endoscope; - a third lens and a fourth lens adapted to form a doublet wherein the focal points of the first lens, the second lens, the third lens, and the fourth lens are disposed along a single optical axis.
A system comprising: a sensor including a sensor pad (306, 1604), the sensor being a chemical field-effect transistor; a well wall structure (302, 2118, 2326) defining a well in operative connection with the sensor pad, a lower surface of the well defined over the sensor pad, the well wall structure having an upper surface and a wall surface extending between the upper surface and the lower surface; a passivation layer (1814, 2014, 2222) disposed over the upper surface, the wall surface and the lower surface; and an isolation layer (1816, 2016, and 2224) disposed over the passivation layer opposite the well wall structure and extending substantially parallel to and at least along a portion of the wall surface, the passivation layer exposed at least along a portion of the upper surface and at least along a portion of the lower surface, wherein the passivation layer includes a high buffer material having an intrinsic buffer capacity of at least 2×10 17 groups/m 2, and wherein the isolation layer includes a low buffer material having an intrinsic buffer capacity of not greater than 1.7×10 17 groups/m 2, wherein the intrinsic buffer capacity is defined as the surface density of hydroxyl groups on a surface of a material measured at a pH of 7. a sensor including a sensor pad (306, 1604), the sensor being a chemical field-effect transistor; a well wall structure (302, 2118, 2326) defining a well in operative connection with the sensor pad, a lower surface of the well defined over the sensor pad, the well wall structure having an upper surface and a wall surface extending between the upper surface and the lower surface; a passivation layer (1814, 2014, 2222) disposed over the upper surface, the wall surface and the lower surface; and an isolation layer (1816, 2016, and 2224) disposed over the passivation layer opposite the well wall structure and extending substantially parallel to and at least along a portion of the wall surface, the passivation layer exposed at least along a portion of the upper surface and at least along a portion of the lower surface, wherein the passivation layer includes a high buffer material having an intrinsic buffer capacity of at least 2×10 17 groups/m 2, and wherein the isolation layer includes a low buffer material having an intrinsic buffer capacity of not greater than 1.7×10 17 groups/m 2, wherein the intrinsic buffer capacity is defined as the surface density of hydroxyl groups on a surface of a material measured at a pH of 7.
Fuel cell device, comprising a fuel cell stack, which comprises a plurality of fuel cell units following one another in a stacking direction, and two end plates (108a, 108b), between which the fuel cell stack is arranged, wherein the fuel cell device comprises an enclosure, which surrounds the fuel cell stack and the end plates (108a, 108b), and wherein the free remaining volume that remains within the enclosure between the enclosure, the fuel cell stack, and the end plates (108a, 108b) is less than 20% of the internal volume of the enclosure, characterized in that the enclosure is fixed to at least one end plate (108a, 108b) by means of at least one fastening arrangement, and in that the fuel cell device comprises at least one cover cap for covering a fastening arrangement. a fuel cell stack, which comprises a plurality of fuel cell units following one another in a stacking direction, and two end plates (108a, 108b), between which the fuel cell stack is arranged, wherein the fuel cell device comprises an enclosure, which surrounds the fuel cell stack and the end plates (108a, 108b), and wherein the free remaining volume that remains within the enclosure between the enclosure, the fuel cell stack, and the end plates (108a, 108b) is less than 20% of the internal volume of the enclosure, characterized in that the enclosure is fixed to at least one end plate (108a, 108b) by means of at least one fastening arrangement, and in that the fuel cell device comprises at least one cover cap for covering a fastening arrangement.
Phenylethynyl derivatives of formula I wherein R 1 is hydrogen, halogen, C 1-4 -alkyl or C 1-4 -alkyl substituted by halogen; R 2 is hydrogen, C 1-4 -alkyl, =O, C 1-4 -alkoxy, phenyl, hydroxy or C 1-4 -alkyl substituted by hydroxy; X is N, CF or CH; L is -NR 3 -, -NHC(R 3) 2 -, -O-, -OC(R 3) 2 -, -CR 4 R 4' -; R 3 is hydrogen or C 1-4 -alkyl; R 4 /R 4' are independently from each other hydrogen or C 1-4 -alkyl; cyc is C 3-7 -cycloalkyl or heterocycloalkyl, selected from the group consisting of tetrahydropyran-2, 3 or 4-yl, oxetan-3-yl, oxazolidinyl, pyrrolidinyl, 1,3-oxazinanyl, tetrahydropyrimidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl or morpholinyl, or is a non-aromatic bicycle selected from 7-oxa-bicyclo[2.2.1]hept-1-yl or bicycle[2.2.1]hept-1-yl; n is 1, 2 or 3; or a pharmaceutically acceptable acid addition salt, a racemic mixture, or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. R 1 is hydrogen, halogen, C 1-4 -alkyl or C 1-4 -alkyl substituted by halogen; R 2 is hydrogen, C 1-4 -alkyl, =O, C 1-4 -alkoxy, phenyl, hydroxy or C 1-4 -alkyl substituted by hydroxy; X is N, CF or CH; L is -NR 3 -, -NHC(R 3) 2 -, -O-, -OC(R 3) 2 -, -CR 4 R 4' -; R 3 is hydrogen or C 1-4 -alkyl; R 4 /R 4' are independently from each other hydrogen or C 1-4 -alkyl; cyc is C 3-7 -cycloalkyl or heterocycloalkyl, selected from the group consisting of tetrahydropyran-2, 3 or 4-yl, oxetan-3-yl, oxazolidinyl, pyrrolidinyl, 1,3-oxazinanyl, tetrahydropyrimidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl or morpholinyl, or is a non-aromatic bicycle selected from 7-oxa-bicyclo[2.2.1]hept-1-yl or bicycle[2.2.1]hept-1-yl; n is 1, 2 or 3;
An insufflation system comprising: - an insufflator (4, 104, 304) having a delivery assembly for delivering insufflating gas from a pressurized source of insufflation gas to at least one gas delivery path; - at least one output line coupled to the at least one gas delivery path; - at least one multi-capacity tube (202, 302) having: - - a first tube (214, 314) with a first end coupled to the at least one output line and a second end connected to a first end of an adapter, and - - at least two second tubes (216, 316) each having a first end attached to a second end of the adapter and a second end having a connector; - a laparoscopic component attached to the connector of at least one of the at least two second tubes (216, 316); and - at least one valve (127,327) attached to each of the at least two second tubes (216, 316) for controlling the flow of insufflating gas; wherein the at least one multi-capacity tube (202, 302) is configured to provide fluid communication of the insufflating gas between the insufflator and the laparoscopic component that is insertable into a peritoneal cavity; characterised in that - the at least one valve (127,327) operates electrically; and - an inner diameter of the first tube (214, 314) is greater than an inner diameter of each of the second tubes (216, 316), and the second tubes (216, 316) are sized to provide a total flow rate of at least 20 litres per minute of insufflating gas to the peritoneal cavity. - an insufflator (4, 104, 304) having a delivery assembly for delivering insufflating gas from a pressurized source of insufflation gas to at least one gas delivery path; - at least one output line coupled to the at least one gas delivery path; - at least one multi-capacity tube (202, 302) having: - - a first tube (214, 314) with a first end coupled to the at least one output line and a second end connected to a first end of an adapter, and - - at least two second tubes (216, 316) each having a first end attached to a second end of the adapter and a second end having a connector; - - a first tube (214, 314) with a first end coupled to the at least one output line and a second end connected to a first end of an adapter, and - - at least two second tubes (216, 316) each having a first end attached to a second end of the adapter and a second end having a connector; - a laparoscopic component attached to the connector of at least one of the at least two second tubes (216, 316); and - at least one valve (127,327) attached to each of the at least two second tubes (216, 316) for controlling the flow of insufflating gas; wherein the at least one multi-capacity tube (202, 302) is configured to provide fluid communication of the insufflating gas between the insufflator and the laparoscopic component that is insertable into a peritoneal cavity; - the at least one valve (127,327) operates electrically; and - an inner diameter of the first tube (214, 314) is greater than an inner diameter of each of the second tubes (216, 316), and the second tubes (216, 316) are sized to provide a total flow rate of at least 20 litres per minute of insufflating gas to the peritoneal cavity.
A targeting system for a bore in a distal end portion of an intramedullary nail, comprising: a distal targeting arm with a first end being configured to be coupled to a trailing end of an intramedullary nail, an adjusting device, the adjusting device being configured to be coupled to the distal targeting arm, wherein the adjusting device comprises an adjusting element and a nail follower including two targeting holes (122, 124) each being configured to receive a sleeve assembly, wherein the adjusting element comprises a first screw and a second screw configured to engage with a first and a second threaded bore of the nail follower and is configured to adjust the position of the nail follower so that the targeting holes (122, 124) correspond to respective locking holes (420, 430) at a leading end of the intramedullary nail, when the nail is bent, characterized in that the first screw comprises a first thread with a first pitch and the second screw comprises a second thread with a second pitch, wherein the first pitch differs from the second pitch and wherein the first and second screws are coupled by a gear with a gear ration of 1:1. a distal targeting arm with a first end being configured to be coupled to a trailing end of an intramedullary nail, an adjusting device, the adjusting device being configured to be coupled to the distal targeting arm, wherein the adjusting device comprises an adjusting element and a nail follower including two targeting holes (122, 124) each being configured to receive a sleeve assembly, wherein the adjusting element comprises a first screw and a second screw configured to engage with a first and a second threaded bore of the nail follower and is configured to adjust the position of the nail follower so that the targeting holes (122, 124) correspond to respective locking holes (420, 430) at a leading end of the intramedullary nail, when the nail is bent, characterized in that the first screw comprises a first thread with a first pitch and the second screw comprises a second thread with a second pitch, wherein the first pitch differs from the second pitch and wherein the first and second screws are coupled by a gear with a gear ration of 1:1.
Fluid catalytic cracking process, which utilises operating conditions of low severity in FCC units to maximise quantity and quality of middle distillates and increase yields of LPG and light olefins; wherein said conditions of operation of low severity comprise a temperature below 510°C, characterised in that it utilises a catalytic system comprising two zeolites, wherein at least one of said zeolites has a pore size equivalent to the size of pores of zeolites of the ferrierite type, wherein at least one of said zeolites comprises a zeolite of ZSM-5 type, wherein said catalytic system contains a percentage by weight of zeolite of the ferrierite type of from 1% to 5%, based on the total weight of the catalyst, and a percentage by weight of zeolite of the ZSM-5 type of less than 2%, based on the total weight of the catalyst.
An infrared sensitive lithographic printing plate precursor of positive-type comprising a support having a hydrophilic surface and an image recording layer provided on the support comprising: an anionic surfactant; an infrared absorbing agent; and a polyuretheane resin, wherein the image recording layer has a configuration in which a lower layer on the side of the support and an upper layer on the side opposite thereto are disposed on the support in this order, the upper layer and/or the lower layer comprising the polyurethane resin, the anionic surfactant and the infrared absorbing agent in the same layer, or in a separate layer. an anionic surfactant; an infrared absorbing agent; and a polyuretheane resin, wherein the image recording layer has a configuration in which a lower layer on the side of the support and an upper layer on the side opposite thereto are disposed on the support in this order, the upper layer and/or the lower layer comprising the polyurethane resin, the anionic surfactant and the infrared absorbing agent in the same layer, or in a separate layer.
An apparatus for restricting a flow of fluid through a bore, the apparatus comprising: a bore sealing member; and an actuation assembly for moving the bore sealing member between a first configuration corresponding to a bore open configuration and a second configuration corresponding to a bore closed configuration, the actuation assembly comprising an activation member with a first end portion and a second end portion, wherein the actuation assembly is configured to isolate the first and second end portions (46, 48) of the activation member from a bore fluid so that the apparatus displaces substantially the same volume of the bore fluid in the first and second configurations, the actuation assembly comprising an isolator comprising a first side configured for receiving the first end portion of the activation member, the actuation assembly defining an isolation chamber between the first end portion and a portion of the isolator, wherein the actuation assembly comprises a first end portion seal configured to prevent the bore fluid entering the isolation chamber so that the first end portion is prevented from contacting the bore fluid and a second end portion seal is configured to prevent the second end portion contacting the bore fluid. a bore sealing member; and an actuation assembly for moving the bore sealing member between a first configuration corresponding to a bore open configuration and a second configuration corresponding to a bore closed configuration, the actuation assembly comprising an activation member with a first end portion and a second end portion, wherein the actuation assembly is configured to isolate the first and second end portions (46, 48) of the activation member from a bore fluid so that the apparatus displaces substantially the same volume of the bore fluid in the first and second configurations, the actuation assembly comprising an isolator comprising a first side configured for receiving the first end portion of the activation member, the actuation assembly defining an isolation chamber between the first end portion and a portion of the isolator, wherein the actuation assembly comprises a first end portion seal configured to prevent the bore fluid entering the isolation chamber so that the first end portion is prevented from contacting the bore fluid and a second end portion seal is configured to prevent the second end portion contacting the bore fluid.
Piston compressor, in particular radial piston compressor, comprising - at least two piston-working chamber combinations (1a-g), wherein - each piston-working chamber combination has at least one fluid inlet channel (11a-g) and one fluid outlet channel (12a-g), wherein - the at least one fluid inlet channel (11a-g) is fluidically connected to a low-pressure collection volume, characterized in that - the low-pressure collection volume comprises a first partial collection volume and at least one second partial collection volume, wherein the first partial collection volume and the second partial collection volume are fluidically connected to one another via a first overflow channel and at least one second overflow channel - at least two piston-working chamber combinations (1a-g), wherein - each piston-working chamber combination has at least one fluid inlet channel (11a-g) and one fluid outlet channel (12a-g), wherein - the at least one fluid inlet channel (11a-g) is fluidically connected to a low-pressure collection volume, characterized in that - the low-pressure collection volume comprises a first partial collection volume and at least one second partial collection volume, wherein the first partial collection volume and the second partial collection volume are fluidically connected to one another via a first overflow channel and at least one second overflow channel