An electro-optical flow measuring device for the characterization of microparticles, comprising a measuring chamber in which the flow of fluid containing the microparticles to be characterized circulates, at least two light sources (S1, S2) of disjoint spectra, a device for measuring resistivity, and at least three other detectors (D1, D2, D3) each allowing the measurement of an optical parameter, the optical parameters being chosen from among fluorescence, extinction, wide angle diffraction, and small angle diffraction, the electro-optical device being such that: - the first light source, the least coherent and having the longest wavelength, defines a main optical axis perpendicular to the flow of particles, the main optical axis having two optical assemblies positioned on either side of the measuring chamber, one being an emitting gun allowing the shaping of the beam emitted by the first source, and the other being a receiving gun allowing the collection of the signal emitted by the first light source and being positioned after the measuring chamber; - the second light source, the most coherent and having the shortest wavelength, defines a secondary optical axis crossing the main optical axis and perpendicular to the flow of particles; - the first detector is placed facing the first source at the extremity of the receiving gun, the first detector being configured to have a light field operation; - the receiving gun comprises collection optics collecting the beam issued from the interaction between the first light source and the particles in the flow towards the first detector, these collection optics being such that over a portion of its pathway, the transmitted light beam is substantially a collimated beam; - the receiving gun comprises a first dichroic mirror at the portion of pathway where the light beam is substantially collimated, to partly reflect the light beam issued from the interaction between the second light source and the particles in the flow towards the second detector placed on the pathway of the partly reflected beam; - the emitting gun comprises beam-shaping optics shaping the beam emitted by the first light source, these beam-shaping optics being such that over a portion of its pathway, the light beam is substantially a collimated beam; and - the emitting gun comprises a second dichroic mirror between the first light source and the measuring chamber, at the portion of pathway where the light beam is substantially collimated, so that it partly reflects the beam issued from the interaction between the second light source and the particles in the flow, towards the third detector placed on the pathway of the partly reflected beam. - the first light source, the least coherent and having the longest wavelength, defines a main optical axis perpendicular to the flow of particles, the main optical axis having two optical assemblies positioned on either side of the measuring chamber, one being an emitting gun allowing the shaping of the beam emitted by the first source, and the other being a receiving gun allowing the collection of the signal emitted by the first light source and being positioned after the measuring chamber; - the second light source, the most coherent and having the shortest wavelength, defines a secondary optical axis crossing the main optical axis and perpendicular to the flow of particles; - the first detector is placed facing the first source at the extremity of the receiving gun, the first detector being configured to have a light field operation; - the receiving gun comprises collection optics collecting the beam issued from the interaction between the first light source and the particles in the flow towards the first detector, these collection optics being such that over a portion of its pathway, the transmitted light beam is substantially a collimated beam; - the receiving gun comprises a first dichroic mirror at the portion of pathway where the light beam is substantially collimated, to partly reflect the light beam issued from the interaction between the second light source and the particles in the flow towards the second detector placed on the pathway of the partly reflected beam; - the emitting gun comprises beam-shaping optics shaping the beam emitted by the first light source, these beam-shaping optics being such that over a portion of its pathway, the light beam is substantially a collimated beam; and - the emitting gun comprises a second dichroic mirror between the first light source and the measuring chamber, at the portion of pathway where the light beam is substantially collimated, so that it partly reflects the beam issued from the interaction between the second light source and the particles in the flow, towards the third detector placed on the pathway of the partly reflected beam.