mhurhangee/ep-ind-claims huggingface dataset:
A method of performing a de novo enzymatic synthesis using digital microfluidics, the method comprising: placing a cartridge having at least one substrate within an air gap of the cartridge, so that a hydrophobic base of the cartridge is in electrical contact with an array of drive electrodes in the DMF apparatus, wherein a plurality of polynucleotide initiator fragments are tethered to the at least one substrate; applying power to the drive electrodes to individually move a series of droplets over the substrate by electrowetting in order to repeat the process of: (a) passing a droplet comprising an enzymatic mix including a single dNTP type over the at least one substrate comprising the plurality of polynucleotide initiator fragments; (b) incubating a droplet on the at least one substrate to add one of the single dNTP type to an end of the polynucleotide initiator fragments; (c) removing the droplet from the at least one substrate; wherein steps (a)-(c) are repeated to synthesize a polynucleotide. placing a cartridge having at least one substrate within an air gap of the cartridge, so that a hydrophobic base of the cartridge is in electrical contact with an array of drive electrodes in the DMF apparatus, wherein a plurality of polynucleotide initiator fragments are tethered to the at least one substrate; applying power to the drive electrodes to individually move a series of droplets over the substrate by electrowetting in order to repeat the process of: (a) passing a droplet comprising an enzymatic mix including a single dNTP type over the at least one substrate comprising the plurality of polynucleotide initiator fragments; (b) incubating a droplet on the at least one substrate to add one of the single dNTP type to an end of the polynucleotide initiator fragments; (c) removing the droplet from the at least one substrate; (a) passing a droplet comprising an enzymatic mix including a single dNTP type over the at least one substrate comprising the plurality of polynucleotide initiator fragments; (b) incubating a droplet on the at least one substrate to add one of the single dNTP type to an end of the polynucleotide initiator fragments; (c) removing the droplet from the at least one substrate; wherein steps (a)-(c) are repeated to synthesize a polynucleotide.
An assembly comprising a staple, in particular for holding objects such as pipes or cables on a support structure, and a threaded member such as a threaded dowel or a screw, of the type comprising a staple body allowing the latter to be mounted on the threaded member, which comprises two parallel rigid walls which are separated from one another by a distance corresponding to the diameter of the threaded object and which are provided on their opposite face with teeth gripping onto the threads of said member when the latter is engaged between the two walls and which are connected to the body by holding walls which are suitable for allowing the toothed walls to move resiliently away from one another during the engagement of the threaded member between these walls, the staple also including a device for disassembling the staple from the threaded member by separating the toothed plates from their gripping position, characterized in that the staple body is made in the form of a cage supporting said objects and in that the toothed plates are mounted in the inner space of the cage and held by holding walls so as to be resiliently movable between their gripping position on the threads of the threaded member and their separated position for disassembling the staple from the threaded member, while remaining in their position parallel to one another, under the effect of a disassembly force applied to the disassembly device and acting in the engagement direction of the threaded member between the toothed plates.
The substrate comprising: an insulating substrate including a first surface and a second surface; and a metal layer that is adhered to the first surface and made of a metal plate, wherein the insulating substrate includes a through hole, the metal layer includes a bent portion, which is inserted into the through hole and protrudes in a direction extending from the first surface to the second surface, and a periphery portion, which is located around the bent portion and adhered to the first surface, the bent portion includes a first end and a second end that are located on opposite sides, the bent portion is bent from the periphery portion at the first end and the second end, the periphery portion is divided into a first periphery portion, which is continuous with the first end of the bent portion, and a second periphery portion, which is continuous with the second end of the bent portion, characterised in that the first periphery portion includes a first side portion that is continuous with the first end of the bent portion, the second periphery portion includes a second side portion that is continuous with the second end of the bent portion, the first and second side portions (33a, 34a) are located on opposite sides of the bent portion, and the first periphery portion and the second periphery portion each include an extension portion (33b, 34b) that extends continuously from a corresponding one of the side portions (33a, 34a), and the extension portions (33b, 34b) extend toward each other. an insulating substrate including a first surface and a second surface; and a metal layer that is adhered to the first surface and made of a metal plate, wherein the insulating substrate includes a through hole, the metal layer includes a bent portion, which is inserted into the through hole and protrudes in a direction extending from the first surface to the second surface, and a periphery portion, which is located around the bent portion and adhered to the first surface, the bent portion includes a first end and a second end that are located on opposite sides, the bent portion is bent from the periphery portion at the first end and the second end, the periphery portion is divided into a first periphery portion, which is continuous with the first end of the bent portion, and a second periphery portion, which is continuous with the second end of the bent portion, characterised in that the first periphery portion includes a first side portion that is continuous with the first end of the bent portion, the second periphery portion includes a second side portion that is continuous with the second end of the bent portion, the first and second side portions (33a, 34a) are located on opposite sides of the bent portion, and the first periphery portion and the second periphery portion each include an extension portion (33b, 34b) that extends continuously from a corresponding one of the side portions (33a, 34a), and the extension portions (33b, 34b) extend toward each other.
A multi-structured tubular element of a reactor for effecting exothermic/endothermic chemical reactions, said element: - having a length from 10 to 1000 times the main dimension of its transversal section, said transversal section being substantially uniform along the whole length of the multi-structured tubular element; and - comprising two or more monolithic thermoconductive bodies extending longitudinally and having the same length as the tubular element, assembled together so that each has a part of the side surface in contact with the side surface of one or more monolithic thermoconductive bodies adjacent thereto, wherein adjacent means that the two or more monolithic thermoconductive bodies are positioned parallel in the direction of length and said two or more monolithic bodies together form a thermally connected honeycomb structure containing a plurality of longitudinal channels, able to contain a granular solid catalyst, extending from one end to the other of said multi-structured tubular element and substantially parallel to each other and to the main axis of the same element and each monolithic body comprises at least a wall that is part of the outer side surface of the multi-structured tubular element and forms from 5 to 80% of said surface. - having a length from 10 to 1000 times the main dimension of its transversal section, said transversal section being substantially uniform along the whole length of the multi-structured tubular element; and - comprising two or more monolithic thermoconductive bodies extending longitudinally and having the same length as the tubular element, assembled together so that each has a part of the side surface in contact with the side surface of one or more monolithic thermoconductive bodies adjacent thereto,
A brachytherapy applicator comprising: two tubes (302, 303) configured to receive radiation sources, each tube (302, 303) having a matching curved end section, wherein the curved end sections of the two tubes are configured to combine to form a ring-shaped applicator having a middle opening; and a central applicator tube configured to receive a radiation source that is located within the middle opening, wherein the central applicator tube comprises a securing mechanism to receive and secure the two tubes (302, 303) to the central applicator tube, characterised in that the central applicator tube further comprises a locking mechanism to secure the curved end sections to the central applicator tube. two tubes (302, 303) configured to receive radiation sources, each tube (302, 303) having a matching curved end section, wherein the curved end sections of the two tubes are configured to combine to form a ring-shaped applicator having a middle opening; and a central applicator tube configured to receive a radiation source that is located within the middle opening, wherein the central applicator tube comprises a securing mechanism to receive and secure the two tubes (302, 303) to the central applicator tube, characterised in that the central applicator tube further comprises a locking mechanism to secure the curved end sections to the central applicator tube.
An illumination source comprising a base and a flexible printed circuit board adapted for attachment to the base, wherein the base comprises multiple sides and a central opening that extends between top and bottom surfaces of the base; the flexible printed circuit board comprises - a flexible body, which is substantially rectangular, comprising a plurality of segments, each segment comprising a set of pairs of body contacts that are electrically isolated from the body contacts of each other segment, wherein each pair of body contacts provides electrical connection to an LED mounted thereon; and - a plurality of flexible legs extending substantially perpendicularly from the flexible body, each flexible leg: extending from a respective segment of the plurality of segments, and comprising a pair of leg contacts disposed proximate to a distal end of the flexible leg from the flexible body, each leg contact connected with a different body contact of the respective segment, and each flexible leg of the flexible printed circuit board adapted to be routed around a bottom edge of the base, along the bottom surface of the base, and into the central opening. the base comprises multiple sides and a central opening that extends between top and bottom surfaces of the base; the flexible printed circuit board comprises - a flexible body, which is substantially rectangular, comprising a plurality of segments, each segment comprising a set of pairs of body contacts that are electrically isolated from the body contacts of each other segment, wherein each pair of body contacts provides electrical connection to an LED mounted thereon; and - a plurality of flexible legs extending substantially perpendicularly from the flexible body, each flexible leg: extending from a respective segment of the plurality of segments, and comprising a pair of leg contacts disposed proximate to a distal end of the flexible leg from the flexible body, each leg contact connected with a different body contact of the respective segment, and each flexible leg of the flexible printed circuit board adapted to be routed around a bottom edge of the base, along the bottom surface of the base, and into the central opening. - a flexible body, which is substantially rectangular, comprising a plurality of segments, each segment comprising a set of pairs of body contacts that are electrically isolated from the body contacts of each other segment, wherein each pair of body contacts provides electrical connection to an LED mounted thereon; and - a plurality of flexible legs extending substantially perpendicularly from the flexible body, each flexible leg: extending from a respective segment of the plurality of segments, and comprising a pair of leg contacts disposed proximate to a distal end of the flexible leg from the flexible body, each leg contact connected with a different body contact of the respective segment, and each flexible leg of the flexible printed circuit board adapted to be routed around a bottom edge of the base, along the bottom surface of the base, and into the central opening.
A method of forming a film on a substrate by electrodeposition comprising: immersing a substrate in an electrolyte comprising a predetermined concentration of ions of a mediating element and a predetermined concentration of ions of a material to be deposited as the film, wherein the mediating element has a Nernst potential lower than the material to be deposited; initiating a forward potential sweep at a first potential which is greater than a bulk deposition potential of the mediating element; sweeping the potential applied to the substrate in a positive direction at a first sweep rate; stopping the positive sweep at a second potential at which the mediating element is removed and the material to be deposited as the film remains; sweeping the potential applied to the substrate in a negative direction at a second sweep rate; stopping the negative sweep at the first potential; and repeating the positive and negative sweeps between the first and second potentials. immersing a substrate in an electrolyte comprising a predetermined concentration of ions of a mediating element and a predetermined concentration of ions of a material to be deposited as the film, wherein the mediating element has a Nernst potential lower than the material to be deposited; initiating a forward potential sweep at a first potential which is greater than a bulk deposition potential of the mediating element; sweeping the potential applied to the substrate in a positive direction at a first sweep rate; stopping the positive sweep at a second potential at which the mediating element is removed and the material to be deposited as the film remains; sweeping the potential applied to the substrate in a negative direction at a second sweep rate; stopping the negative sweep at the first potential; and repeating the positive and negative sweeps between the first and second potentials.
Starting device comprising a starter motor and a relay having a thrust device and a switching device for energizing the starter motor, wherein both a lifting means of the thrust device and a lifting means of the switching device are to be respectively moved by means of a electromagnetic circuit (179, 210), characterized in that the electromagnetic circuit of the thrust device 160 and the electromagnetic circuit of the switching device are separated by an electromagnetically non-excitable intermediate part, wherein on both sides of the intermediate part an electromagnetically excitable core part (167, 168) is arranged respectively, wherein the one core part is a part of the electromagnetic circuit of the thrust device and the other core part is a part of the electromagnetic circuit of the switching device.
Workpiece (2, 5, 6, 14, 20, 23) for a hydraulic device (1, 15), comprising at least in part a coating layer, characterized in that the coating layer contains Mo with a weight fraction between 75% and 90%, Ni with a weight fraction between 2% and 5%, Cr with a weight fraction between 2% and 5%, B with a weight fraction between 2% and 5%, Si with a weight fraction between 2% and 5% and Fe with a weight fraction between 2% and 5%, and essentially no Pb, the constituents adding up to 100%.
A cylindrical battery comprising: a battery case having a cylindrical shape; an electrode group disposed in the battery case, the electrode group comprising a positive electrode, a negative electrode, and a separator, the electrode group having a pair of flat outer side surfaces opposed to each other; and a spacer (6; 61, 62) disposed between an inner peripheral surface of the battery case and each of the flat outer side surfaces of the electrode group, characterized in that the spacer (6; 61, 62) has a flat electrode contact portion having a first surface serving as a contact surface with one of the outer side surfaces of the electrode group, and a case contact portion provided on a second surface of the electrode contact portion and extends continuously from a first axial end to a second axial end of the electrode contact portion, the case contact portion being in contact with the inner peripheral surface of the battery case and partitioning a space formed between the outer side surface of the electrode group and the inner peripheral surface of the battery case, and the case contact portion is formed with at least one communicating portion that communicates spaces partitioned by the case contact portion. a battery case having a cylindrical shape; an electrode group disposed in the battery case, the electrode group comprising a positive electrode, a negative electrode, and a separator, the electrode group having a pair of flat outer side surfaces opposed to each other; and a spacer (6; 61, 62) disposed between an inner peripheral surface of the battery case and each of the flat outer side surfaces of the electrode group, characterized in that the spacer (6; 61, 62) has a flat electrode contact portion having a first surface serving as a contact surface with one of the outer side surfaces of the electrode group, and a case contact portion provided on a second surface of the electrode contact portion and extends continuously from a first axial end to a second axial end of the electrode contact portion, the case contact portion being in contact with the inner peripheral surface of the battery case and partitioning a space formed between the outer side surface of the electrode group and the inner peripheral surface of the battery case, and the case contact portion is formed with at least one communicating portion that communicates spaces partitioned by the case contact portion.
A computer-implemented method for planning an ablation plan of a target tissue in a patient, the method comprising: receiving data characterizing patient-specific anatomy comprising at least the target tissue, wherein the data include data on dielectric properties associated with the target tissue; calculating by computer simulated results of one or more operations to lesion the target tissue, based on the received data; producing a planned target form of the lesion, wherein the planned target form is selected based on one or more criteria evaluated on the simulated results; providing an indication of the planned target form; producing an ablation plan for producing the planned target form; wherein the received data characterize geometry of a target anatomical structure, and the ablation plan describes the adjustment of parameters of ablation as a function of geometry along the planned target form of the lesion; characterized in that the parameters of ablation are adjusted as a function of structure thickness along the planned target form of the lesion. receiving data characterizing patient-specific anatomy comprising at least the target tissue, wherein the data include data on dielectric properties associated with the target tissue; calculating by computer simulated results of one or more operations to lesion the target tissue, based on the received data; producing a planned target form of the lesion, wherein the planned target form is selected based on one or more criteria evaluated on the simulated results; providing an indication of the planned target form; producing an ablation plan for producing the planned target form; wherein the received data characterize geometry of a target anatomical structure, and the ablation plan describes the adjustment of parameters of ablation as a function of geometry along the planned target form of the lesion; characterized in that the parameters of ablation are adjusted as a function of structure thickness along the planned target form of the lesion.
A therapeutic pessary or a vaginal insertion aid for the active therapy or prophylaxis during the risk of urinary incontinence and/or descensus by actively supporting the convalescence of weakened pelvic connective tissue structures, which are substantially responsible for the aforementioned symptoms, in a controlled manner, comprising at least two elongated, skid-shaped parts, which are held at a selectable distance from each other, characterised in that the skid-shaped pessary parts are each comprised of elongated, oval ring bodies (2, 3) which are formed in the same way by tubular sections annularly closed in themselves, with selected, circular diameters.
A plunger for use by being fitted into a cylinder of a pneumatic dispenser that discharges a viscous material by using pressurized air, wherein an inner chamber of the cylinder is divided by the fitting of the plunger therein into a filling chamber into which the viscous material is filled from the outside and a pressurizing chamber into which the pressurized air is charged from the outside, wherein the plunger comprises a cylindrical main body portion that axially extends and has an outer circumferential surface, and the plunger further comprising a seal formed between the outer circumferential surface and an inner circumferential surface of the cylinder, in a fitted state in which the plunger is fitted within the cylinder, characterized in that the outer circumferential surface, in the fitted state, substantially circumferentially forms a radial clearance between the outer circumferential surface and the inner circumferential surface, thereby forming a tubular clearance, which serves as a continuous clearance, between the outer circumferential surface and the inner circumferential surface such that the tubular clearance continuously extends both in axial and circumferential directions, and when the viscous material is filled into the filling chamber from the outside, the continuous clearance is filled with a portion of the viscous material, thereby forming the seal, wherein said portion of the viscous material blocks the rest of the viscous material from leaking from the filling chamber into the pressurizing chamber.