An oxadiazole amine derivative compound represented by the following formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: wherein R 1 is -CF 2 H or -CF 3; L 1 and L 2 are each independently -(C 1 -C 2 alkylene)- or a bond; Z 1 to Z 4 are each independently N or CR Z {wherein three or more of Z 1 to Z 4 cannot be N at the same time}, wherein R Z is -H, -F, -Cl, -Br, -I or -O(C 1 -C 4 alkyl); R 2 is -H or -(C 1 -C 4 alkyl); Y 1 is -CH 2 -, -NR c -, -O-, -C(=O)- or -S(=O) 2 -, wherein R c is -H, -(C 1 -C 6 alkyl), -(C 1 -C 4 alkyl)-OH, -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl)-aryl, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), aryl, -(C 1 -C 4 alkyl)-aryl, -(C 2 -C 4 alkenyl)-aryl, heteroaryl, -(C 1 -C 4 alkyl)-heteroaryl, -C(=O)-(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl) or -(C 1 -C 4 alkyl)-C(=O)-(C 2 -C 6 heterocycloalkyl), {wherein at least one H of the -(C 1 -C 6 alkyl), -(C 1 -C 4 alkyl)-OH, -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl)-aryl, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), aryl, -(C 1 -C 4 alkyl)-aryl, (C 2 -C 4 alkenyl)-aryl, heteroaryl, -(C 1 -C 4 alkyl)-heteroaryl, -C(=O)-(C 3 -C 7 cycloalkyl), -C 2 -C 6 heterocycloaklyl or -(C 1 -C 4 alkyl)-C(=O)-(C 2 -C 6 heterocycloalkyl) may be substituted with -X}; a and b are each independently an integer of 0, 1, 2, 3 or 4 {wherein the a and b cannot all be 0}; L 3 is -(C 1 -C 2 alkylene)-, -SO 2 -, -(C 1 -C 2 alkylene)-SO 2 -, or a bond; is -aryl, -heteroaryl, or heterocycloalkyl, wherein Z 5 and Z 6 are each independently -CH 2 - or -O-; and R 4 to R 6 are each independently -H, -F, -Cl, -Br, -I, -OH, -O(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl), -CF 3, -OCF 3, heterocycloalkyl {wherein the heterocycloalkyl may be unsubstituted or substituted with C 1 -C 4 alkyl or heterocycloalkyl}, -O-aryl, -CF 2 H, -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -NR A R B, -C(=O)-NR A R B or -S(=O) 2 -(C 1 -C 4 alkyl), wherein Y 2 is -CH 2 -, -O-, -C(=O)- or -S(=O) 2 -, Y 3 to Y 5 are each independently -CH- or -N-, and c to f are each independently an integer of 0, 1, 2, 3 or 4{wherein c and e cannot all be 0, and d and f cannot all be 0}, wherein R A and R B are each independently -H or -(C 1 -C 4 alkyl) {wherein at least one H of the -(C 1 -C 4 alkyl) may be substituted with -X or -OH}, wherein X is F, Cl, Br or I. wherein R 1 is -CF 2 H or -CF 3; L 1 and L 2 are each independently -(C 1 -C 2 alkylene)- or a bond; Z 1 to Z 4 are each independently N or CR Z {wherein three or more of Z 1 to Z 4 cannot be N at the same time}, wherein R Z is -H, -F, -Cl, -Br, -I or -O(C 1 -C 4 alkyl); R 2 is -H or -(C 1 -C 4 alkyl); Y 1 is -CH 2 -, -NR c -, -O-, -C(=O)- or -S(=O) 2 -, wherein R c is -H, -(C 1 -C 6 alkyl), -(C 1 -C 4 alkyl)-OH, -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl)-aryl, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), aryl, -(C 1 -C 4 alkyl)-aryl, -(C 2 -C 4 alkenyl)-aryl, heteroaryl, -(C 1 -C 4 alkyl)-heteroaryl, -C(=O)-(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl) or -(C 1 -C 4 alkyl)-C(=O)-(C 2 -C 6 heterocycloalkyl), {wherein at least one H of the -(C 1 -C 6 alkyl), -(C 1 -C 4 alkyl)-OH, -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl)-aryl, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), aryl, -(C 1 -C 4 alkyl)-aryl, (C 2 -C 4 alkenyl)-aryl, heteroaryl, -(C 1 -C 4 alkyl)-heteroaryl, -C(=O)-(C 3 -C 7 cycloalkyl), -C 2 -C 6 heterocycloaklyl or -(C 1 -C 4 alkyl)-C(=O)-(C 2 -C 6 heterocycloalkyl) may be substituted with -X}; a and b are each independently an integer of 0, 1, 2, 3 or 4 {wherein the a and b cannot all be 0}; L 3 is -(C 1 -C 2 alkylene)-, -SO 2 -, -(C 1 -C 2 alkylene)-SO 2 -, or a bond; is -aryl, -heteroaryl, or heterocycloalkyl, wherein Z 5 and Z 6 are each independently -CH 2 - or -O-; and R 4 to R 6 are each independently -H, -F, -Cl, -Br, -I, -OH, -O(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl), -CF 3, -OCF 3, heterocycloalkyl {wherein the heterocycloalkyl may be unsubstituted or substituted with C 1 -C 4 alkyl or heterocycloalkyl}, -O-aryl, -CF 2 H, -C(=O)-(C 1 -C 4 alkyl), -C(=O)-O(C 1 -C 4 alkyl), -NR A R B, -C(=O)-NR A R B or -S(=O) 2 -(C 1 -C 4 alkyl), wherein Y 2 is -CH 2 -, -O-, -C(=O)- or -S(=O) 2 -, Y 3 to Y 5 are each independently -CH- or -N-, and c to f are each independently an integer of 0, 1, 2, 3 or 4{wherein c and e cannot all be 0, and d and f cannot all be 0}, wherein R A and R B are each independently -H or -(C 1 -C 4 alkyl) {wherein at least one H of the -(C 1 -C 4 alkyl) may be substituted with -X or -OH}, wherein X is F, Cl, Br or I.