A system to transmit packetized data in a voice activated packet-based computer network environment, comprising: a data processing system, the data processing system comprising: a natural language processor component adapted to receive, via an interface of the data processing system, data packets comprising an input audio signal detected at a first interface of a client device; the natural language processor component to parse the input audio signal to identify a request and a trigger keyword corresponding to the request; a direct action application programming interface of the data processing system to generate, based on at least one of the request and the trigger keyword, a first action data structure comprising a response to the input audio signal; a content selector component adapted to receive at least one of the request and the trigger keyword identified by the natural language processor component and to select, based on the at least one of the request and the trigger keyword, a digital component via a real-time content selection process, wherein the digital component comprises a content item, and wherein the first action data structure is separate to the content item; and an interface management component of the data processing system to: identify a second interface associated with the client device; determine that the second interface associated with the client device previously received a prior instance of the digital component; determine to not transmit the digital component to the client device based on the second interface having previously received the prior instance of the digital component; and transmit the first action data structure, and not the digital component, to the client device to render as audio output from the client device, based on the determination to not transmit the digital component to the client device. a natural language processor component adapted to receive, via an interface of the data processing system, data packets comprising an input audio signal detected at a first interface of a client device; the natural language processor component to parse the input audio signal to identify a request and a trigger keyword corresponding to the request; a direct action application programming interface of the data processing system to generate, based on at least one of the request and the trigger keyword, a first action data structure comprising a response to the input audio signal; a content selector component adapted to receive at least one of the request and the trigger keyword identified by the natural language processor component and to select, based on the at least one of the request and the trigger keyword, a digital component via a real-time content selection process, wherein the digital component comprises a content item, and wherein the first action data structure is separate to the content item; and an interface management component of the data processing system to: identify a second interface associated with the client device; determine that the second interface associated with the client device previously received a prior instance of the digital component; determine to not transmit the digital component to the client device based on the second interface having previously received the prior instance of the digital component; and transmit the first action data structure, and not the digital component, to the client device to render as audio output from the client device, based on the determination to not transmit the digital component to the client device. identify a second interface associated with the client device; determine that the second interface associated with the client device previously received a prior instance of the digital component; determine to not transmit the digital component to the client device based on the second interface having previously received the prior instance of the digital component; and transmit the first action data structure, and not the digital component, to the client device to render as audio output from the client device, based on the determination to not transmit the digital component to the client device.