A method of preparing an amine compound of formula, the method comprising the steps of: (i) preparing an amide of formula; and (ii) reacting the amide of formula to form the amine compound of formula, and and have the structures shown below: where: R A is -SO 2 R 10 or -R N, Cy is optionally substituted C 5-6 cycloalkadienyl; D is an optionally substituted straight- or branched-chain C 1-4 alkyl group, or D is a group: where L 1 is a covalent bond or optionally substituted C 1-3 alkyl; and L 2 is a covalent bond or optionally substituted C 1-2 alkyl; G is selected from -O-, -S-, and optionally substituted C 6-10 aryl, optionally substituted C 3-10 heteroaryl and optionally substituted C 6-10 cycloalkyl; and the asterisk indicates the point of attachment to Cy; A is *-CH 2 NHC(R 6 R 7)- or *-C(R 4 R 5)NHCH 2 -, where the asterisk indicates the point of attachment to D; E is *-C NHC(R 6 R 7)- or *-C(R 4 R 5)NHC -, where the asterisk indicates the point of attachment to D; R 4 and R 5 are each independently selected from the group consisting of hydrogen, straight- or branched-chain C 1-20 alkyl, straight, branched or cyclic C 1-10 alkoxy, C 6-10 aryl and C 6-10 aryloxy, -OH, -CN, and -CF 3; R 6, R 7, R 8 and R 9 are each independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C 1-20 alkyl, optionally substituted straight, branched or cyclic C 1-20 alkoxy, optionally substituted C 6-20 aryl and optionally substituted C 6-20 aryloxy, or R 6 and R 7 together with the carbon atom to which they are bound and/or R 8 and R 9 together with the carbon atom to which they are bound form an optionally substituted C 3-20 cycloalkyl or an optionally substituted C 2-20 cycloalkoxy, or one of R 6 and R 7 and one of R 8 and R 9 together form an optionally substituted C 5-10 cycloalkyl or an optionally substituted C 5-10 cycloalkoxy; R 10 is hydrogen, an optionally substituted straight, branched or cyclic C 1-10 alkyl, an optionally substituted C 6-10 aryl or -NR 11 R 12, where R 11 and R 12 are independently selected from the group consisting of optionally substituted straight- or branched-chain C 1-10 alkyl and optionally substituted C 6-10 aryl; R N is hydrogen, or straight, branched or cyclic C 1-10 alkyl; R 11 and R 12 are independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C 1-10 alkyl and optionally substituted C 6-10 aryl, or R 11 and R 12 together with the nitrogen atom to which they are bound form an optionally substituted C 2-10 cycloalkyl-amino group. (i) preparing an amide of formula; and (ii) reacting the amide of formula to form the amine compound of formula, R A is -SO 2 R 10 or -R N, Cy is optionally substituted C 5-6 cycloalkadienyl; D is an optionally substituted straight- or branched-chain C 1-4 alkyl group, or D is a group: where L 1 is a covalent bond or optionally substituted C 1-3 alkyl; and L 2 is a covalent bond or optionally substituted C 1-2 alkyl; G is selected from -O-, -S-, and optionally substituted C 6-10 aryl, optionally substituted C 3-10 heteroaryl and optionally substituted C 6-10 cycloalkyl; and the asterisk indicates the point of attachment to Cy; L 1 is a covalent bond or optionally substituted C 1-3 alkyl; and L 2 is a covalent bond or optionally substituted C 1-2 alkyl; G is selected from -O-, -S-, and optionally substituted C 6-10 aryl, optionally substituted C 3-10 heteroaryl and optionally substituted C 6-10 cycloalkyl; and the asterisk indicates the point of attachment to Cy; A is *-CH 2 NHC(R 6 R 7)- or *-C(R 4 R 5)NHCH 2 -, where the asterisk indicates the point of attachment to D; E is *-C NHC(R 6 R 7)- or *-C(R 4 R 5)NHC -, where the asterisk indicates the point of attachment to D; R 4 and R 5 are each independently selected from the group consisting of hydrogen, straight- or branched-chain C 1-20 alkyl, straight, branched or cyclic C 1-10 alkoxy, C 6-10 aryl and C 6-10 aryloxy, -OH, -CN, and -CF 3; R 6, R 7, R 8 and R 9 are each independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C 1-20 alkyl, optionally substituted straight, branched or cyclic C 1-20 alkoxy, optionally substituted C 6-20 aryl and optionally substituted C 6-20 aryloxy, or R 6 and R 7 together with the carbon atom to which they are bound and/or R 8 and R 9 together with the carbon atom to which they are bound form an optionally substituted C 3-20 cycloalkyl or an optionally substituted C 2-20 cycloalkoxy, or one of R 6 and R 7 and one of R 8 and R 9 together form an optionally substituted C 5-10 cycloalkyl or an optionally substituted C 5-10 cycloalkoxy; R 10 is hydrogen, an optionally substituted straight, branched or cyclic C 1-10 alkyl, an optionally substituted C 6-10 aryl or -NR 11 R 12, where R 11 and R 12 are independently selected from the group consisting of optionally substituted straight- or branched-chain C 1-10 alkyl and optionally substituted C 6-10 aryl; R N is hydrogen, or straight, branched or cyclic C 1-10 alkyl; R 11 and R 12 are independently selected from the group consisting of hydrogen, optionally substituted straight, branched or cyclic C 1-10 alkyl and optionally substituted C 6-10 aryl, or R 11 and R 12 together with the nitrogen atom to which they are bound form an optionally substituted C 2-10 cycloalkyl-amino group.