A method of manufacturing a plurality of wireless sensor patches comprising the steps of: unwinding a skin-friendly adhesive membrane from a skin-friendly adhesive membrane storage roll, wherein the skin-friendly adhesive membrane includes a substrate sheet carrying a layer of skin-friendly adhesive and a first release liner carried by the layer of skin-friendly adhesive, wherein the layer of skin-friendly adhesive is sandwiched between the first release liner and the substrate sheet; kiss cutting the substrate sheet and the skin-friendly adhesive to the first release liner to define a skin-friendly adhesive patch; unwinding a flexible support membrane from a support membrane storage roll, wherein the flexible support membrane includes a flexible support sheet with a skin adhesive layer applied to a first face of the flexible support sheet and a second release liner carried by the skin adhesive layer with the skin adhesive layer being sandwiched between the second release liner and the flexible support sheet; kiss cutting the flexible support sheet and the skin adhesive layer to the second release liner to define an opening extending through the flexible support sheet and the skin adhesive layer; removing the second release liner to expose the skin adhesive layer; laminating the substrate sheet to the flexible support sheet with the skin adhesive layer of the flexible support membrane; unwinding a tie layer membrane from a tie layer membrane storage roll, wherein the tie layer membrane includes a tie layer carrying a third release liner; (VIII) kiss cutting the tie layer to the third release liner to define a tie layer patch; laminating the tie layer patch to the flexible support sheet; cutting at least one probe opening through the tie layer membrane in alignment with the opening defined during step; removing the third release liner to expose the tie layer patch laminated to the flexible support sheet; mounting a sensor device with respect to the flexible support membrane with a sensor probe in alignment with corresponding openings defined during steps and; (XIII) unwinding a flexible cover membrane from a flexible cover membrane storage roll; forming a pocket within the flexible cover membrane; cutting the flexible cover membrane to define a flexible cover patch including the pocket; laminating the flexible cover patch to the tie layer patch with the sensor device being at least partially received in the pocket; and (XVII) cutting the flexible support sheet and the skin adhesive layer to provide a wireless sensor patch. unwinding a skin-friendly adhesive membrane from a skin-friendly adhesive membrane storage roll, wherein the skin-friendly adhesive membrane includes a substrate sheet carrying a layer of skin-friendly adhesive and a first release liner carried by the layer of skin-friendly adhesive, wherein the layer of skin-friendly adhesive is sandwiched between the first release liner and the substrate sheet; kiss cutting the substrate sheet and the skin-friendly adhesive to the first release liner to define a skin-friendly adhesive patch; unwinding a flexible support membrane from a support membrane storage roll, wherein the flexible support membrane includes a flexible support sheet with a skin adhesive layer applied to a first face of the flexible support sheet and a second release liner carried by the skin adhesive layer with the skin adhesive layer being sandwiched between the second release liner and the flexible support sheet; kiss cutting the flexible support sheet and the skin adhesive layer to the second release liner to define an opening extending through the flexible support sheet and the skin adhesive layer; removing the second release liner to expose the skin adhesive layer; laminating the substrate sheet to the flexible support sheet with the skin adhesive layer of the flexible support membrane; unwinding a tie layer membrane from a tie layer membrane storage roll, wherein the tie layer membrane includes a tie layer carrying a third release liner; (VIII) kiss cutting the tie layer to the third release liner to define a tie layer patch; laminating the tie layer patch to the flexible support sheet; cutting at least one probe opening through the tie layer membrane in alignment with the opening defined during step; removing the third release liner to expose the tie layer patch laminated to the flexible support sheet; mounting a sensor device with respect to the flexible support membrane with a sensor probe in alignment with corresponding openings defined during steps and; (XIII) unwinding a flexible cover membrane from a flexible cover membrane storage roll; forming a pocket within the flexible cover membrane; cutting the flexible cover membrane to define a flexible cover patch including the pocket; laminating the flexible cover patch to the tie layer patch with the sensor device being at least partially received in the pocket; and (XVII) cutting the flexible support sheet and the skin adhesive layer to provide a wireless sensor patch.