A system for delivering energy-based treatment for treating tissues proximate to a body lumen, the system comprising: an elongate flexible catheter body having a proximal end and a distal end with an axis therebetween; a radially expandable structure near the distal end of the catheter body, wherein the expandable structure comprises a balloon; a plurality of electrodes (634; 700) positioned on the radially expandable structure so as to engage tissue upon expansion of the radially expandable structure, wherein the electrodes positioned on the balloon are included in one or more flex circuits, wherein the one or more flex circuits further comprise a temperature sensing structure mounted thereon in proximity to at least one of the electrodes; a power source coupled with the electrodes (634; 700) such that when an electrode engages tissue an electrical circuit comprising the power source, the electrode (634; 700), and the engaged tissue is defined; a processor coupled with the power source and the temperature sensing structure, the processor configured to verify the presence of the electrical circuit, to selectively energize the engaged electrodes (634; 700), and to control the delivery of energy by regulating one or more parameters of the electrical circuit based on monitoring feedback from the electrical circuit and the temperature sensing structure such that energy delivered to a tissue treatment zone heats tissue therein to a temperature of about 55°C to about 75°C while tissue collateral to the treatment zone is heated to less than about 45°C, thereby inducing a tissue response; wherein the electrodes (634; 700) are energized in a sequence and wherein a first group of electrodes (634; 700) is energized in a sequence so as to define a first pattern of treatment zones, and wherein a second group of electrodes (634; 700) is energized in a sequence so as to define a second pattern of treatment zones, so as to minimize the gap between the first and second pattern of treatment zones. an elongate flexible catheter body having a proximal end and a distal end with an axis therebetween; a radially expandable structure near the distal end of the catheter body, wherein the expandable structure comprises a balloon; a plurality of electrodes (634; 700) positioned on the radially expandable structure so as to engage tissue upon expansion of the radially expandable structure, wherein the electrodes positioned on the balloon are included in one or more flex circuits, wherein the one or more flex circuits further comprise a temperature sensing structure mounted thereon in proximity to at least one of the electrodes; a power source coupled with the electrodes (634; 700) such that when an electrode engages tissue an electrical circuit comprising the power source, the electrode (634; 700), and the engaged tissue is defined; a processor coupled with the power source and the temperature sensing structure, the processor configured to verify the presence of the electrical circuit, to selectively energize the engaged electrodes (634; 700), and to control the delivery of energy by regulating one or more parameters of the electrical circuit based on monitoring feedback from the electrical circuit and the temperature sensing structure such that energy delivered to a tissue treatment zone heats tissue therein to a temperature of about 55°C to about 75°C while tissue collateral to the treatment zone is heated to less than about 45°C, thereby inducing a tissue response; wherein the electrodes (634; 700) are energized in a sequence and wherein a first group of electrodes (634; 700) is energized in a sequence so as to define a first pattern of treatment zones, and wherein a second group of electrodes (634; 700) is energized in a sequence so as to define a second pattern of treatment zones, so as to minimize the gap between the first and second pattern of treatment zones.