A compound having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein: X is -O-, -S 0-2 -, -C(=O)-, -C(OR 5) 2 -, -C(OR 5)(OC(=O)R 13)-, -C(R 8 R 9)-, -C(=CR 8 R 9)-, -N(R 9)-, -N(COR 9)-, -CHNR 8 R 9 -, -C(=NR 9)-, -C(=NOR 5)-, or -C(=N-NHR 5)-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13; R 3 is optionally substituted group selected from a group consisting of pyrrole, pyrazole, pyridine, pyridazine, pyrimidine, imidazole, thiazole, isoxazole, oxadiazole, thiadiazole, oxazole, triazole, isothiazole, oxazine, triazine, azepine, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, morpholine, thiomorpholine, piperazine, and tetrazine; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S 0-2 R 5, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5, or R 8 and R 9 can join to form an unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a, R 11b, R 11c and R 11d are each independently H, F, Cl, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -OR 5, -OC(=O)R 13, C 1 -C 10 acyl, -S 0-2 R 5, -NO 2, -CN, -NH 2, -NHR 5, or -N(R 5) 2, R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; n 3 is 0, 1, 2, 3, 4, or 5; the optional substituent is each independently -NR g R h, -NR g C(=O)R h, -NR g C(=O)NR g R h, -NR g C(=O)OR h, -NR g SO 2 R h, -OC(=O)NR g R h, -OR g, -SR g, -SOR g, -SO 2 R g, -OSO 2 R g, -SO 2 OR g, =NSO 2 R g, -SO 2 NR g R h, -C(=O)R g, -C(=O)OR g, -C(=O)NR g R h, -CH 2 SO 2 R g, -CH 2 SO 2 NR g R h, amino, cyano, hydroxyl, imino, nitro, oxo, thioxo, halo, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, N -heterocyclyl, heterocyclylalkyl, heteroaryl, N -heteroaryl or heteroarylalkyl; and R g and R h are the same or different and independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, N -heterocyclyl, heterocyclylalkyl, heteroaryl, N -heteroaryl or heteroarylalkyl; wherein at least one of R 11a, R 11b, R 11c and R 11d is Cl, Br, I or 123 I. X is -O-, -S 0-2 -, -C(=O)-, -C(OR 5) 2 -, -C(OR 5)(OC(=O)R 13)-, -C(R 8 R 9)-, -C(=CR 8 R 9)-, -N(R 9)-, -N(COR 9)-, -CHNR 8 R 9 -, -C(=NR 9)-, -C(=NOR 5)-, or -C(=N-NHR 5)-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13; R 3 is optionally substituted group selected from a group consisting of pyrrole, pyrazole, pyridine, pyridazine, pyrimidine, imidazole, thiazole, isoxazole, oxadiazole, thiadiazole, oxazole, triazole, isothiazole, oxazine, triazine, azepine, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, morpholine, thiomorpholine, piperazine, and tetrazine; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S 0-2 R 5, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5, or R 8 and R 9 can join to form an unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a, R 11b, R 11c and R 11d are each independently H, F, Cl, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -OR 5, -OC(=O)R 13, C 1 -C 10 acyl, -S 0-2 R 5, -NO 2, -CN, -NH 2, -NHR 5, or -N(R 5) 2, R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; n 3 is 0, 1, 2, 3, 4, or 5; the optional substituent is each independently -NR g R h, -NR g C(=O)R h, -NR g C(=O)NR g R h, -NR g C(=O)OR h, -NR g SO 2 R h, -OC(=O)NR g R h, -OR g, -SR g, -SOR g, -SO 2 R g, -OSO 2 R g, -SO 2 OR g, =NSO 2 R g, -SO 2 NR g R h, -C(=O)R g, -C(=O)OR g, -C(=O)NR g R h, -CH 2 SO 2 R g, -CH 2 SO 2 NR g R h, amino, cyano, hydroxyl, imino, nitro, oxo, thioxo, halo, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, N -heterocyclyl, heterocyclylalkyl, heteroaryl, N -heteroaryl or heteroarylalkyl; and R g and R h are the same or different and independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, thioalkyl, aryl, aralkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkylalkyl, haloalkyl, haloalkenyl, haloalkynyl, heterocyclyl, N -heterocyclyl, heterocyclylalkyl, heteroaryl, N -heteroaryl or heteroarylalkyl; wherein at least one of R 11a, R 11b, R 11c and R 11d is Cl, Br, I or 123 I.