A lyophilized peptibody composition comprising a buffer, a bulking agent, a stabilizing agent, and a surfactant; wherein said buffer is comprised of a pH buffering agent, wherein: a) said pH buffering agent is 10 mM histidine and the pH is 5.0; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.004% w/v polysorbate-20; or b) said pH buffering agent is 10 mM histidine and the pH is 7.0; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.01% w/v polysorbate-20; or c) said pH buffering agent is 10 mM histidine and the pH is 5.0; said bulking agent is 2.5% w/v mannitol; and said stabilizing agent is 3.5% w/v sucrose; or d) said pH buffering agent is 10 mM histidine and the pH is 4.5; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.004% w/v polysorbate-20; or e) said pH buffering agent is 20 mM histidine and the pH is 5.0; said bulking agent is 4.0% w/v mannitol; and said stabilizing agent is 2.0% w/v sucrose; and wherein said peptibody comprises a structure set out in Formula I, Formula 1: [(X 1) a -F 1 -(X 2) b] -(L 1) c -WSP d wherein: F 1 is an Fc domain; X 1 is selected from: P 1 -(L 2) e - P 2 -(L 3) f -P 1 -(L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g P 2 -(L 3) f -P 1 -(L 2) e; X 2 is selected from: - (L 2) e -P 1, - (L 2) e -P 1 -(L 3) f -P 2, - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) f -P 3 -(L 5) h -P 4; wherein P 1, P 2, P 3, and P 4 are each independently sequences of pharmacologically active peptides; L 1, L 2, L 3, L 4, and L 5 are each independently linkers; a, b, c, e, f, g, and h are each independently 0 or 1, provided that at least one of a and b is 1; d is 0, 1, or greater than 1; and WSP is a water soluble polymer, the attachment of which is effected at any reactive moiety in F 1. a) said pH buffering agent is 10 mM histidine and the pH is 5.0; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.004% w/v polysorbate-20; or b) said pH buffering agent is 10 mM histidine and the pH is 7.0; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.01% w/v polysorbate-20; or c) said pH buffering agent is 10 mM histidine and the pH is 5.0; said bulking agent is 2.5% w/v mannitol; and said stabilizing agent is 3.5% w/v sucrose; or d) said pH buffering agent is 10 mM histidine and the pH is 4.5; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.004% w/v polysorbate-20; or e) said pH buffering agent is 20 mM histidine and the pH is 5.0; said bulking agent is 4.0% w/v mannitol; and said stabilizing agent is 2.0% w/v sucrose; F 1 is an Fc domain; X 1 is selected from: P 1 -(L 2) e - P 2 -(L 3) f -P 1 -(L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g P 2 -(L 3) f -P 1 -(L 2) e; P 1 -(L 2) e - P 2 -(L 3) f -P 1 -(L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g P 2 -(L 3) f -P 1 -(L 2) e; X 2 is selected from: - (L 2) e -P 1, - (L 2) e -P 1 -(L 3) f -P 2, - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) f -P 3 -(L 5) h -P 4; wherein P 1, P 2, P 3, and P 4 are each independently sequences of pharmacologically active peptides; - (L 2) e -P 1, - (L 2) e -P 1 -(L 3) f -P 2, - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and - (L 2) e -P 1 -(L 3) f -P 2 -(L 4) f -P 3 -(L 5) h -P 4; L 1, L 2, L 3, L 4, and L 5 are each independently linkers; a, b, c, e, f, g, and h are each independently 0 or 1, provided that at least one of a and b is 1; d is 0, 1, or greater than 1; and WSP is a water soluble polymer, the attachment of which is effected at any reactive moiety in F 1.