An on-body wearable bio-fluid collection and sensing device, the device comprising: - an interface surface for contacting a bodily part, the interface surface comprising at least one biocompatible material for contacting the bodily part; - at least one inlet for receiving the bio-fluid; - at least one outlet for evacuating the bio-fluid; - at least one micro-fluidic or nano-fluidic channel configured to transfer the bio-fluid from the at least one inlet through the at least one micro-fluidic or nano-fluidic channel and out the at least one outlet via capillary motion; the device being characterized in that it further includes: - a plurality of semiconductor sensors configured to analyze the received bio-fluid; - at least one reference electrode for biasing a bio-fluid gate of at least one of the semiconductor sensors; and in that the at least one micro-fluidic or nano-fluidic channel is in fluid communication with the at least one inlet, the at least one outlet and the at least one reference electrode; the at least one micro-fluidic or nano-fluidic channel including the plurality of semiconductor sensors, and in that the plurality of semiconductor sensors are included on a first semiconductor or through-silicon-via substrate and the at least one micro-fluidic or nano-fluidic channel is included on a second substrate, and the first semiconductor or through-silicon-via substrate and the second substrate are connected one to the other and form an integral device, and the second substrate includes the least one reference electrode embedded therein to contact the bio-fluid, the second substrate including an opening and a micro-fluidic or nano-fluidic channel allowing the reference electrode to be in fluidic communication with the bio-fluid. - an interface surface for contacting a bodily part, the interface surface comprising at least one biocompatible material for contacting the bodily part; - at least one inlet for receiving the bio-fluid; - at least one outlet for evacuating the bio-fluid; - at least one micro-fluidic or nano-fluidic channel configured to transfer the bio-fluid from the at least one inlet through the at least one micro-fluidic or nano-fluidic channel and out the at least one outlet via capillary motion; the device being characterized in that it further includes: - a plurality of semiconductor sensors configured to analyze the received bio-fluid; - at least one reference electrode for biasing a bio-fluid gate of at least one of the semiconductor sensors; and - a plurality of semiconductor sensors configured to analyze the received bio-fluid; - at least one reference electrode for biasing a bio-fluid gate of at least one of the semiconductor sensors; and in that the at least one micro-fluidic or nano-fluidic channel is in fluid communication with the at least one inlet, the at least one outlet and the at least one reference electrode; the at least one micro-fluidic or nano-fluidic channel including the plurality of semiconductor sensors, and in that the plurality of semiconductor sensors are included on a first semiconductor or through-silicon-via substrate and the at least one micro-fluidic or nano-fluidic channel is included on a second substrate, and the first semiconductor or through-silicon-via substrate and the second substrate are connected one to the other and form an integral device, and the second substrate includes the least one reference electrode embedded therein to contact the bio-fluid, the second substrate including an opening and a micro-fluidic or nano-fluidic channel allowing the reference electrode to be in fluidic communication with the bio-fluid.