mhurhangee/ep-ind-claims huggingface dataset:
An isolated monoclonal antibody or antigen-binding fragment thereof, comprising: a heavy chain variable region comprising the sequence set forth as SEQ ID NO: 1 with up to 10 conservative amino acid substitutions in the framework regions of the heavy chain and a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3 comprising amino acids 26-33, 51-57, and 96-108 of SEQ ID NO: 1, respectively; and a light chain variable region comprising the sequence set forth as SEQ ID NO: 2 with up to 10 conservative amino acid substitutions in the framework regions of the light chain and a light chain complementarity determining region (LCDR)1, a LCDR2, and a LCDR3 comprising amino acids 27-32, 50-52, and 89-97 of SEQ ID NO: 2, respectively, wherein the monoclonal antibody or antigen binding fragment specifically binds to Ebola virus glycoprotein and neutralizes Ebola virus. a heavy chain variable region comprising the sequence set forth as SEQ ID NO: 1 with up to 10 conservative amino acid substitutions in the framework regions of the heavy chain and a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3 comprising amino acids 26-33, 51-57, and 96-108 of SEQ ID NO: 1, respectively; and a light chain variable region comprising the sequence set forth as SEQ ID NO: 2 with up to 10 conservative amino acid substitutions in the framework regions of the light chain and a light chain complementarity determining region (LCDR)1, a LCDR2, and a LCDR3 comprising amino acids 27-32, 50-52, and 89-97 of SEQ ID NO: 2, respectively, wherein the monoclonal antibody or antigen binding fragment specifically binds to Ebola virus glycoprotein and neutralizes Ebola virus.
Assembly comprising an inner rail and an outer rail of the body of a motor vehicle, these two rails (1, 2) together forming a hollow body, a partition designed to reinforce the body against side impacts extending transversely between said rails (1, 2) and a support for a seat belt retractor being attached to said inner rail in an area located substantially facing said partition, said support for a belt retractor being attached to both said inner rail and said partition, characterised in that said partition is a part made of sheet metal and folded into the shape of a U, the ends of each of the two legs of this U comprising a rebate that is attached onto the outer face of said inner rail.
A method of charging an energy storage device, the method comprising: wirelessly coupling to a rotating member contained in a housing using a coil attached to an exterior of the housing; charging an energy storage device using a current induced in the coil during rotation of the rotating member in response to a request for charging the energy storage device; and switching to charging of the energy storage device based on wirelessly coupling to a changing magnetic field from an AC line used to power the rotating member, responsive to the rotating member being dormant for an extended period. wirelessly coupling to a rotating member contained in a housing using a coil attached to an exterior of the housing; charging an energy storage device using a current induced in the coil during rotation of the rotating member in response to a request for charging the energy storage device; and switching to charging of the energy storage device based on wirelessly coupling to a changing magnetic field from an AC line used to power the rotating member, responsive to the rotating member being dormant for an extended period.
A thermally conductive composition comprising a matrix resin made of a thermosetting resin, a curing catalyst, and thermally conductive particles, wherein the thermally conductive particles include the following (a) to (c) with respect to 100 parts by mass of the matrix resin: (a) 600 to 1500 parts by mass of spherical alumina with an average particle size of more than 100 μm; (b) 100 to 400 parts by mass of alumina with an average particle size of 1 μm or less; and (c) 500 to 1500 parts by mass of aluminum nitride with an average particle size of 0.8 to 150 μm, wherein the average particle size is measured according to the method used in the examples, and wherein a degree of plasticity of the thermally conductive composition after defoaming and before curing is 80 or less as measured according to the Examples. wherein the thermally conductive particles include the following (a) to (c) with respect to 100 parts by mass of the matrix resin: (a) 600 to 1500 parts by mass of spherical alumina with an average particle size of more than 100 μm; (b) 100 to 400 parts by mass of alumina with an average particle size of 1 μm or less; and (c) 500 to 1500 parts by mass of aluminum nitride with an average particle size of 0.8 to 150 μm, wherein the average particle size is measured according to the method used in the examples, and (a) 600 to 1500 parts by mass of spherical alumina with an average particle size of more than 100 μm; (b) 100 to 400 parts by mass of alumina with an average particle size of 1 μm or less; and (c) 500 to 1500 parts by mass of aluminum nitride with an average particle size of 0.8 to 150 μm, wherein the average particle size is measured according to the method used in the examples, and wherein a degree of plasticity of the thermally conductive composition after defoaming and before curing is 80 or less as measured according to the Examples.
A microchip comprising a substrate layer structure comprising a first substrate layer (c 1) a second substrate layer (c 2), and a third substrate layer (c 3), the first substrate layer (c 1) being laminated to a first side of the second substrate layer, the third substrate layer (c 3) being laminated to a second side of the second substrate layer (c 2); a fluid channel configured to contain a sample solution, wherein the second substrate layer (c 2) consists of a self-sealing substrate layer configured to allow self-sealing of the substrate structure subsequent to injection of the sample solution, the first and third substrate layer (c 1, c 3) consist of gas-impermeable substrate layers, the fluid channel formed between the second substrate layer and at least the third substrate layer having a pressure lower than atmospheric pressure.
A method of connecting an NFC reader to a plurality of NFC devices, the plurality of NFC devices comprising at least one NFC-A device and at least one RF barcode, the method comprising the steps of: detecting and logging the active and sleep intervals of the RF barcode when an RF field is switched on; and synchronizing the transmission and reception of data to, and from, the or each NFC-A device such that transmission and reception of data to, and from, the or each NFC-A device occurs only when the or each RF barcode is in a sleep interval.
Transport tool for transporting a pipette tip carrier or a microplate (2"') using a pipette of a pipetting system, wherein the transport tool at least comprises: a) a plug-in sleeve, which is implemented to form a releasable plug connection with a receptacle cone of a pipette of the pipetting system, and which comprises an interior, a sleeve axis, and a receptacle opening, wherein the receptacle cone, which is implemented for plugging on a disposable pipette tip of a pipette of the pipetting system, can be plugged through the receptacle opening into the interior of the plug-in sleeve, and wherein the interior of the plug-in sleeve is embodied so that the transport tool can be plugged onto the receptacle cone of the pipette instead of a disposable pipette tip and can also be discarded again from the receptacle cone of this pipette; b) an article holder, which comprises a holding axis and at least one holding means, which is implemented to form a support connection with a pipette tip carrier or a microplate (2"'), and c) a connecting part, which connects the at least one article holder to the plug-in sleeve at its end opposite to the receptacle opening, so that the holding axis (axes) of the at least one article holder and the sleeve axis of the plug-in sleeve are arranged coaxially or axially-parallel to one another, wherein the article holder comprises a holding means, which is implemented as at least approximately spherical, ellipsoidal, or ovoid, or alternatively, the article holder is implemented as an oblong hollow body and comprises a plurality of holding means implemented as projections, which are arranged on an outer side of the article holder, and wherein the article holder is implemented to form a friction-locked plug connection with a storage opening in the pipette tip carrier or with a well (5") of the microplate (2'"). a) a plug-in sleeve, which is implemented to form a releasable plug connection with a receptacle cone of a pipette of the pipetting system, and which comprises an interior, a sleeve axis, and a receptacle opening, wherein the receptacle cone, which is implemented for plugging on a disposable pipette tip of a pipette of the pipetting system, can be plugged through the receptacle opening into the interior of the plug-in sleeve, and wherein the interior of the plug-in sleeve is embodied so that the transport tool can be plugged onto the receptacle cone of the pipette instead of a disposable pipette tip and can also be discarded again from the receptacle cone of this pipette; b) an article holder, which comprises a holding axis and at least one holding means, which is implemented to form a support connection with a pipette tip carrier or a microplate (2"'), and c) a connecting part, which connects the at least one article holder to the plug-in sleeve at its end opposite to the receptacle opening, so that the holding axis (axes) of the at least one article holder and the sleeve axis of the plug-in sleeve are arranged coaxially or axially-parallel to one another,
A vehicle body structure comprising: a front frame member disposed in a front part of a vehicle body; a rear frame member disposed in a rear part of the vehicle body; and paired left and right middle frame members disposed on outer sides, in a vehicle width direction, of the vehicle body, respectively, and extending in a vehicle front-rear direction between the front frame member and the rear frame member, wherein each of the paired left and right middle frame members includes a first middle frame member (29, 129) disposed on an outer side in the vehicle width direction, and a second middle frame member disposed inward, in the vehicle width direction, of the first middle frame member (29, 129) and coupling the front frame member and the rear frame member to each other, the second middle frame member extends in such a way as to shift farther outward in the vehicle width direction as it gets closer to rear of the vehicle, characterized in that the strength of the second middle frame member is set larger than strength of the first middle frame member (29, 129), and in that the structure further comprises a first support frame member which couples the second middle frame member and the first middle frame member to each other, wherein the first support frame member extends obliquely in such a way as to shift farther outward in the vehicle width direction as it gets closer to front of the vehicle. a front frame member disposed in a front part of a vehicle body; a rear frame member disposed in a rear part of the vehicle body; and paired left and right middle frame members disposed on outer sides, in a vehicle width direction, of the vehicle body, respectively, and extending in a vehicle front-rear direction between the front frame member and the rear frame member, wherein each of the paired left and right middle frame members includes a first middle frame member (29, 129) disposed on an outer side in the vehicle width direction, and a second middle frame member disposed inward, in the vehicle width direction, of the first middle frame member (29, 129) and coupling the front frame member and the rear frame member to each other, the second middle frame member extends in such a way as to shift farther outward in the vehicle width direction as it gets closer to rear of the vehicle, characterized in that the strength of the second middle frame member is set larger than strength of the first middle frame member (29, 129), and in that the structure further comprises a first support frame member which couples the second middle frame member and the first middle frame member to each other, wherein the first support frame member extends obliquely in such a way as to shift farther outward in the vehicle width direction as it gets closer to front of the vehicle.
A sheet metal connector for a suspended ceiling cross runner, the connector having a laterally extending resilient tab bent at a line out of a plane of a main part of the connector, the tab extending outwardly and rearwardly from said bend line, the tab having a free edge (43, 44) away from the bend line, the tab being configured to grip a side of a main runner opposite the side from which the connector is inserted in a hole to effectuate a connection to the main runner and having a portion adapted to remain within the hole when the connector is fully assembled in the hole whereby the connection between the connector and main runner formed by the tab has improved tensile strength as a result of the tab portion preventing the tab from over-bending, characterised in that the connector has elements (28, 29) to interlock with an identical connector when both the connector and an identical connector are assembled from opposite sides of a main runner in a common hole and are in lateral abutment, and in that the tab is arranged to be resiliently bent back towards the plane of the main body of the connector by an edge of the hole when a cross runner associated with the connector is twisted along its longitudinal axis so as to release the connection formed by the tab with the main runner.
Pressure container system for a motor vehicle, comprising: - at least one pressure container for storing fuel, wherein the pressure container system has an isolating valve which is designed to interrupt, in the deenergized state, the fluid connection between the pressure container and at least one combustion gas consumer; and - at least one safety switch, wherein the safety switch is designed to interrupt the supply of power to the isolating valve, wherein the safety switch is not an ignition switch of a motor vehicle. - at least one pressure container for storing fuel, wherein the pressure container system has an isolating valve which is designed to interrupt, in the deenergized state, the fluid connection between the pressure container and at least one combustion gas consumer; and - at least one safety switch, wherein the safety switch is designed to interrupt the supply of power to the isolating valve, wherein the safety switch is not an ignition switch of a motor vehicle.
Apparatus for controlling a fluid pump for a motor vehicle, wherein the apparatus is characterized by: - a first control device which is configured to actuate an electric prime mover of the fluid pump by impressing at least one motor current with an adapted current intensity and an adapted waveform; and - a second control device which is configured to detect a rotational speed of the electric prime mover and to apply an adapted voltage to the electric prime mover on the basis of the detected rotational speed; wherein the apparatus is configured to compare the detected rotational speed of the electric prime mover with a rotational speed threshold value for the electric prime mover. - a first control device which is configured to actuate an electric prime mover of the fluid pump by impressing at least one motor current with an adapted current intensity and an adapted waveform; and - a second control device which is configured to detect a rotational speed of the electric prime mover and to apply an adapted voltage to the electric prime mover on the basis of the detected rotational speed;
An anti-VEGF antibody, or an anti-VEGF binding fragment thereof which comprises CDRs having amino acid sequences corresponding to SEQ ID NO:3 (CDR-H1), SEQ ID NO:4 (CDR-H2), SEQ ID NO:5 (CDR-H3), SEQ ID NO:6 (CDR-L1), SEQ ID NO:7 (CDR-L2) and SEQ ID NO:8 (CDR-L3), wherein CDRH1 includes the substitution N31 F and optionally also T28P, further optionally wherein the CDRs include one or more additional mutations or combinations of mutations selected from one or more of Tables 6, 7, 8, 9, 10, 11, 12-1 to 12-9 and 13, wherein the six CDRs altogether have up to 17 amino acid substitutions as compared to CDR sequences of the antibody bevacizumab, and wherein CDR-H1 in said anti-VEGF antibody does not consist of a CDR-H1 sequence set forth in Tables 12-1 to 12-9, and wherein the anti-VEGF antibody or anti-VEGF binding fragment thereof has a greater affinity to human VEGF than bevacizumab and wherein all substitution numbering is according to Kabat.
A transfer carrier comprising: - a carrier layer; and - a transfer layer; wherein the transfer layer is arranged above the carrier layer and is detachable from the carrier layer; wherein the transfer carrier includes a transfer restriction (15, 18), and wherein the transfer restriction (15, 18) comprises a transfer layer interruption which serves as a boundary between a transfer section of the transfer layer to be transferred and a carrier section of the transfer layer remaining on the carrier layer, wherein the transfer restriction (15, 18) further comprises an anti-adhesive structure, the anti-adhesive structure is provided next to the transfer layer interruption, and the anti-adhesive structure above at least one of the two sections (1, 2) is provided only partially, characterized in that the anti-adhesive structure is arranged above the transfer layer. - a carrier layer; and - a transfer layer; wherein the transfer layer is arranged above the carrier layer and is detachable from the carrier layer; wherein the transfer carrier includes a transfer restriction (15, 18), and wherein the transfer restriction (15, 18) comprises a transfer layer interruption which serves as a boundary between a transfer section of the transfer layer to be transferred and a carrier section of the transfer layer remaining on the carrier layer, wherein the transfer restriction (15, 18) further comprises an anti-adhesive structure, the anti-adhesive structure is provided next to the transfer layer interruption, and the anti-adhesive structure above at least one of the two sections (1, 2) is provided only partially, characterized in that the anti-adhesive structure is arranged above the transfer layer. wherein the transfer layer is arranged above the carrier layer and is detachable from the carrier layer; wherein the transfer carrier includes a transfer restriction (15, 18), and wherein the transfer restriction (15, 18) comprises a transfer layer interruption which serves as a boundary between a transfer section of the transfer layer to be transferred and a carrier section of the transfer layer remaining on the carrier layer, wherein the transfer restriction (15, 18) further comprises an anti-adhesive structure, the anti-adhesive structure is provided next to the transfer layer interruption, and the anti-adhesive structure above at least one of the two sections (1, 2) is provided only partially, characterized in that the anti-adhesive structure is arranged above the transfer layer.
A method for preparing 2-ethylhexyl-acrylate using a dividing wall column comprising a main column comprising: a condenser; a reboiler; and a dividing wall, wherein the main column is divided into a top zone, an upper inflow zone, an upper outflow zone, a lower inflow zone, a lower outflow zone, and a bottom zone, and comprises at least one inflow stream and at least three outflow streams, wherein the at least one inflow stream is a stream that a feed containing crude 2-ethylhexyl-acrylate flows into an inflow middle plate where the upper inflow zone and the lower inflow zone of the main column contact each other, and one or more of the outflow streams is a stream of 2-ethylhexyl-acrylate, wherein a low boiling component flows out in the top zone, a high boiling component B flows out in the bottom zone, a medium boiling component flows out to an outflow middle plate where the upper outflow zone and the lower outflow zone contact each other, and the medium boiling component flowing out to the outflow middle plate is 2-ethylhexyl-acrylate, wherein a temperature of the top zone ranges from 88°C to 98°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr), wherein a temperature of an outflow middle plate which is provided at a position where the upper outflow zone and the lower outflow zone contact each other and to which a medium boiling component flows out ranges from 124°C to 134°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr), and wherein a temperature of the bottom zone ranges from 138°C to 148°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr). a condenser; a reboiler; and a dividing wall, wherein the main column is divided into a top zone, an upper inflow zone, an upper outflow zone, a lower inflow zone, a lower outflow zone, and a bottom zone, and comprises at least one inflow stream and at least three outflow streams, wherein the at least one inflow stream is a stream that a feed containing crude 2-ethylhexyl-acrylate flows into an inflow middle plate where the upper inflow zone and the lower inflow zone of the main column contact each other, and one or more of the outflow streams is a stream of 2-ethylhexyl-acrylate, wherein a low boiling component flows out in the top zone, a high boiling component B flows out in the bottom zone, a medium boiling component flows out to an outflow middle plate where the upper outflow zone and the lower outflow zone contact each other, and the medium boiling component flowing out to the outflow middle plate is 2-ethylhexyl-acrylate, wherein a temperature of the top zone ranges from 88°C to 98°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr), wherein a temperature of an outflow middle plate which is provided at a position where the upper outflow zone and the lower outflow zone contact each other and to which a medium boiling component flows out ranges from 124°C to 134°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr), and wherein a temperature of the bottom zone ranges from 138°C to 148°C at a pressure in the top zone of 1,999.8 Pa to 3,333 Pa (15 to 25 torr).
A chromatography column module stackable with like chromatography modules, comprising a column chamber fluidically connected to a column inlet (3;103;203;303) and a column outlet (4;104;204;304), wherein said column inlet and said column outlet each comprise a valve (5;305), arranged to move from a closed position to an open position upon connection of said column inlet or outlet with a) a column outlet or inlet of a like chromatography module or b) with an outlet or inlet of a fluidics plate, wherein said valve comprises a spring-loaded valve member (8;308) resting on a valve seat (9;309) when the valve is in the closed position and wherein, upon connection with a column inlet or outlet of a like chromatography column module, a valve opening member (7;307) causes said valve to move to an open position by urging said valve member away from said valve seat; characterized in that said valve member comprises a frustoconical segment (10;310), which when the valve is in the closed position is in sealing abutment against a frustoconical bore segment (11;311) of said column inlet or outlet.