An implantable bioartificial perfusion system for providing a physiological regulating secretion necessary for functionality of a physiologic activity of a living-being host, the system comprising: a) a housing having an inlet with an external opening thereto and an outlet with an external opening therefrom, the housing implantable at least partially within the host such that the inlet and outlet openings (14, 18) are positionable in fluidic communication with tissue fluid of the host for receiving into and dispensing from the housing the tissue fluid, wherein the housing includes a self charging mechanism charging a rechargable battery, when a patient with the implantable bioartificial perfusison system is moving; b) a chamber disposed within the housing between the inlet and outlet and in communication therewith, the chamber having a scaffold, providing capillary forces so that a plurality of physiologically active, autonomously and in concert functioning, live secretory cells, being pancreatic beta-islet cells, for producing insulin are in constant communication with the moving tissue fluid, wherein the scaffold comprises autologous or allogeneic extracellular matrix molecules and seeded with a plurality of ECM cells comprising fibroblasts, macrophages, and endothelial cells; c) a constantly operating two pump apparatus for drawing initial tissue fluid through the inlet from the host for contact with the physiologically active cells within the chamber for pick up of the physiological regulating secretion, and for dispensing resulting tissue fluid bearing the physiological regulating secretion through the outlet and into the host; and d) an inlet filter in operational communication with the external opening of the inlet and disposed upstream of the chamber, the inlet filter comprising a nanoporous membrane filter having pores therethrough sized for prohibiting passage into the chamber of immune system cells of the host. a) a housing having an inlet with an external opening thereto and an outlet with an external opening therefrom, the housing implantable at least partially within the host such that the inlet and outlet openings (14, 18) are positionable in fluidic communication with tissue fluid of the host for receiving into and dispensing from the housing the tissue fluid, wherein the housing includes a self charging mechanism charging a rechargable battery, when a patient with the implantable bioartificial perfusison system is moving; b) a chamber disposed within the housing between the inlet and outlet and in communication therewith, the chamber having a scaffold, providing capillary forces so that a plurality of physiologically active, autonomously and in concert functioning, live secretory cells, being pancreatic beta-islet cells, for producing insulin are in constant communication with the moving tissue fluid, wherein the scaffold comprises autologous or allogeneic extracellular matrix molecules and seeded with a plurality of ECM cells comprising fibroblasts, macrophages, and endothelial cells; c) a constantly operating two pump apparatus for drawing initial tissue fluid through the inlet from the host for contact with the physiologically active cells within the chamber for pick up of the physiological regulating secretion, and for dispensing resulting tissue fluid bearing the physiological regulating secretion through the outlet and into the host; and d) an inlet filter in operational communication with the external opening of the inlet and disposed upstream of the chamber, the inlet filter comprising a nanoporous membrane filter having pores therethrough sized for prohibiting passage into the chamber of immune system cells of the host.