mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a non-covalent association complex of: (a) a positively-charged polymeric backbone having covalently attached thereto a plurality of positively charged amino acid sequences selected from -(gly) n1 -(arg) n2, wherein n1 is an integer from 0 to 20, and n2 is an odd integer from 5 to 25; (gly)p-RGRDDRRQRRR-(gly) q; (gly) p -YGRKKRRQRRR-(gly) q, wherein the subscripts p and q are each independently an integer of from 0 to 20; or a positively charged HIV-TAT peptide domain; and (b) at least two members selected from the group consisting of: i) a first negatively-charged backbone having a plurality of attached imaging moieties; ii) a second negatively-charged backbone having a plurality of attached targeting agents; and iii a third negatively-charged backbone having a plurality of attached biological agents; wherein each of said biological agents is a therapeutic or a cosmeceutical agent selected from the group consisting of botulinum toxin, EGF, TGF-β1, insulin, VEGF, a blocker ofVEGF and antibodies to VEGF; wherein said non-covalent association complex carries a net positive charge and at least one of said two members of (b) is selected from group i) or group iii). (a) a positively-charged polymeric backbone having covalently attached thereto a plurality of positively charged amino acid sequences selected from -(gly) n1 -(arg) n2, wherein n1 is an integer from 0 to 20, and n2 is an odd integer from 5 to 25; (gly)p-RGRDDRRQRRR-(gly) q; (gly) p -YGRKKRRQRRR-(gly) q, wherein the subscripts p and q are each independently an integer of from 0 to 20; or a positively charged HIV-TAT peptide domain; and (b) at least two members selected from the group consisting of: i) a first negatively-charged backbone having a plurality of attached imaging moieties; ii) a second negatively-charged backbone having a plurality of attached targeting agents; and iii a third negatively-charged backbone having a plurality of attached biological agents; wherein each of said biological agents is a therapeutic or a cosmeceutical agent selected from the group consisting of botulinum toxin, EGF, TGF-β1, insulin, VEGF, a blocker ofVEGF and antibodies to VEGF; wherein said non-covalent association complex carries a net positive charge and at least one of said two members of (b) is selected from group i) or group iii). i) a first negatively-charged backbone having a plurality of attached imaging moieties; ii) a second negatively-charged backbone having a plurality of attached targeting agents; and iii a third negatively-charged backbone having a plurality of attached biological agents; wherein each of said biological agents is a therapeutic or a cosmeceutical agent selected from the group consisting of botulinum toxin, EGF, TGF-β1, insulin, VEGF, a blocker ofVEGF and antibodies to VEGF; wherein said non-covalent association complex carries a net positive charge and at least one of said two members of (b) is selected from group i) or group iii).
An engineered penicillin G acylase having a polypeptide sequence that is at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more identical to SEQ ID NO: 1036, and comprises a N2L mutation, wherein said position is numbered with reference to SEQ ID NO: 1036, and wherein said penicillin G acylase is capable of producing phenyl acetate mono-protected or di-protected insulin and has an improvement in enzyme activity of at least 1.5 times the enzymatic activity of SEQ ID NO: 1036.
A method for synchronizing a terminal mirror, comprising: obtaining (101, 111, 201), by a terminal, multiple input events during running of application software; aggregating (102, 111, 203), by the terminal, the multiple input events to obtain an aggregate event; and transmitting (103, 111, 205), by the terminal, the aggregate event to a server; parsing (103, 112, 207), by the server, the aggregate event to obtain the multiple input events; processing (103, 113, 208), by the server, the multiple input events by application software executed within a virtual machine of the terminal on the server to obtain user data generated during the running of the application software.
Optical or magnetic scale configured for carrying out linear measurements, also of a great length, on a tool machine or on another type of machine, comprising a scale-holder consisting of one or more modules which are mutually assembled and aligned on said machine, the scale-holder comprising a continuous groove and sliding guides within the scale-holder, the scale further comprising a single steel strip bearing the scale-grating and housed in said continuous groove and a reading slider which is configured to slide on said sliding guides within the scale-holder to perform the reading of said scale-grating, wherein said sliding guides comprise the surface of the steel strip bearing the scale-grating and a guide edge of said steel strip configured to permit free longitudinal sliding of the reading slider throughout the entire length of the steel strip.
A microstructure for a light-emitting element, comprising a plurality of microscopic convex parts (a) each having a circular bottom surface, wherein the convex part has a peak (q) on a perpendicular line at a center of the bottom surface (p) and is defined by a generatrix connecting the peak and a circumference of the bottom surface, the generatrix of the convex part is formed by monotonically reducing height from the peak to the circumference of the bottom surface, the height of the peak (q) of the convex part is 0.67 to 1.15 times as large as a radius of the bottom surface, the height of the convex part at a position of 3/4 of the radius of the bottom surface from the center of the bottom surface is 0.37 to 0.53 times as large as the radius of the bottom surface, and the height of the convex part at a position of 9/10 of the radius of the bottom surface from the center of the bottom surface is 0.04 to 0.38 times as large as the radius of the bottom surface, characterised in that the generatrix has a curvature with an inflection point.
A joint lock comprising a lock body, which has a housing that accommodates a locking mechanism, and a jointed bar hoop which has a plurality of jointed bars pivotably connected to one another and a locking bar, wherein the locking bar can be selectively locked to the lock body by means of the locking mechanism, wherein the locking mechanism is at least partly held in a holder which is fixed in the housing by means of a latch connection, characterized in that the housing has at least one edge to which the holder is fixed by means of at least one latch nose.
Holder assembly (107; 207) for the automatable handling of big bags having a suspension arrangement (150,250) for retaining a carrying arrangement, specifically a coil loop, connected to a big bag, wherein the suspension arrangement (150,250) comprises an actuator (151,251) and a holding arrangement (153;253) which is adjustable between a holding position and a releasing position, wherein the holding arrangement comprises two fingers (154, 155) each of which extends along a clamping finger axis (156, 157), and each of which comprises an effective surface which extends along the direction of the clamping finger axis (156, 157), between which the carrying arrangement is fixable, specifically clampably, in a friction-locked and/or form-locked manner in the holding position, characterized in that the suspension arrangement (150; 250) comprises a gear mechanism (152; 252), which acts between the actuator (151; 251) and the holding arrangement (153; 253) and transforms an adjusting force applied by the actuator (151; 251) into a holding force (F H) which acts at the holding arrangement.
Rocket engine having a thrust chamber bounded by a casing construction with a chamber longitudinal axis, wherein the casing construction includes at least one cooling channel adapted to be fluidically connected with a source of a cooling medium, wherein the cooling channel is traversed by a plurality of bridge elements (30, 32, 34, 36, 38) around which the cooling medium flows and which each extend only over a part, in particular a minor part, of the length of the cooling channel measured along the chamber longitudinal axis, and which connect two casing wall pieces (21, 23), bounding the cooling channel on the inside and on the outside of the casing construction, to one another, wherein the two casing wall pieces (21, 23) are formed of annular wall parts arranged concentrically within one another and separated from one another by a radial annular space, wherein at least a partial number of the bridge elements (30, 32, 34, 36, 38) are implemented as bridge webs which are longer than they are wide when viewed in a sectional area oriented along the casing wall pieces (21, 23), characterised in that at least a partial number of the bridge webs - when viewed in the sectional area - are oriented with their web longitudinal direction parallel to the chamber longitudinal axis, and in that at least a partial number of the bridge webs - when viewed in the sectional area - are oriented with their web longitudinal direction at an acute angle obliquely with respect to the chamber longitudinal axis.
A network for handling a clear channel assessment, CCA, in an unlicensed band, comprising: a storage unit for storing instructions of: suspending transmitting at least one first orthogonal frequency division multiplexing, OFDM, symbol in a subframe on a component carrier; performing a CCA operation within duration of the at least one first OFDM symbol in the subframe on the component carrier; and determining to perform a transmission in a subframe when determining the component carrier is not busy according to the CCA operation, wherein the transmission of at least one OFDM symbol is off in the subframe; and a processing means, coupled to the storage unit and configured to execute the instructions stored in the storage unit, wherein the network is not allowed to transmit an incomplete OFDM symbol when the CCA operation ends within an OFDM symbol of the at least one first OFDM symbol. a storage unit for storing instructions of: suspending transmitting at least one first orthogonal frequency division multiplexing, OFDM, symbol in a subframe on a component carrier; performing a CCA operation within duration of the at least one first OFDM symbol in the subframe on the component carrier; and determining to perform a transmission in a subframe when determining the component carrier is not busy according to the CCA operation, wherein the transmission of at least one OFDM symbol is off in the subframe; and suspending transmitting at least one first orthogonal frequency division multiplexing, OFDM, symbol in a subframe on a component carrier; performing a CCA operation within duration of the at least one first OFDM symbol in the subframe on the component carrier; and determining to perform a transmission in a subframe when determining the component carrier is not busy according to the CCA operation, wherein the transmission of at least one OFDM symbol is off in the subframe; and a processing means, coupled to the storage unit and configured to execute the instructions stored in the storage unit, wherein the network is not allowed to transmit an incomplete OFDM symbol when the CCA operation ends within an OFDM symbol of the at least one first OFDM symbol.
A method comprising: determining, for each a plurality of packet-optical transport devices interconnected to form an optical transport system, a respective channel group size specifying a number of optical channels to reserve for each of the packet-optical transport devices from a total number of optical channels for the optical transport system, wherein the respective channel group size for each of the packet-optical transport devices is determined based on a bandwidth requirement for the respective packet-optical transport device; reserving, in accordance with the each of the determined channel group sizes, a set of optical channels for each of the packet-optical transport devices from an optical spectrum supported by the packet-optical transport devices, each of the reserved optical channels having an unassigned wavelength, and each of the sets of optical channels being associated with a different portion of the optical spectrum and having an spectral range that is based on the channel group size determined for the respective packet-optical transport device; and for each of the packet-optical transport devices, assigning a respective wavelength from the optical spectrum to one or more of the optical channels of the set of optical channels reserved for the packet-optical transport device to balance network traffic associated with the packet-optical transport device around a center of the portion of the optical spectrum associated with the set of optical channels reserved for the packet-optical transport device. determining, for each a plurality of packet-optical transport devices interconnected to form an optical transport system, a respective channel group size specifying a number of optical channels to reserve for each of the packet-optical transport devices from a total number of optical channels for the optical transport system, wherein the respective channel group size for each of the packet-optical transport devices is determined based on a bandwidth requirement for the respective packet-optical transport device; reserving, in accordance with the each of the determined channel group sizes, a set of optical channels for each of the packet-optical transport devices from an optical spectrum supported by the packet-optical transport devices, each of the reserved optical channels having an unassigned wavelength, and each of the sets of optical channels being associated with a different portion of the optical spectrum and having an spectral range that is based on the channel group size determined for the respective packet-optical transport device; and for each of the packet-optical transport devices, assigning a respective wavelength from the optical spectrum to one or more of the optical channels of the set of optical channels reserved for the packet-optical transport device to balance network traffic associated with the packet-optical transport device around a center of the portion of the optical spectrum associated with the set of optical channels reserved for the packet-optical transport device.
An induction heating device for industrial purposes or industrial applications with at least one surface inductor having an induction coil to which an AC voltage can be applied and with a heating element that can be heated by the surface inductor and has a surface facing the surface inductor, and with a magnetic yoke for conducting the magnetic field generated or generatable by the induction coil, wherein the induction coil and the magnetic yoke are designed such that a constant power input per surface area takes place to heat the heating element via the surface of the heating element facing the surface inductor and a homogenous temperature field is generated or can be generated in the heating element over the surface facing the surface inductor, wherein the induction coil has at least one nonuniform winding, wherein the distances between the windings are increased in field regions with a strong coupling to the heating element, while the windings have a narrower distance in field regions with a weak coupling, characterized in that, in addition to the induction coil, the surface inductor has an additional winding in a different winding plane than the winding plane of the induction coil at at least one local position.
A particle detector comprising at least: ∘ one channel for receiving at least one fluid comprising particles; ∘ one optical input configured to receive at least one incident light radiation; characterised in that the detector further comprises: ∘ a first plurality of reflecting surfaces disposed between the optical input and the channel; ∘ an array of photodetectors facing the channel; ∘ a second plurality of reflecting surfaces disposed between the channel and the array of photodetectors and so that the channel is located between the first and second plurality of reflecting surfaces; the first and second pluralities of reflecting surfaces, the array of photodetectors and the channel being disposed so that at least part of the incident light radiation going through the channel is scattered by at least one particle present in the channel thus forming scattered light rays, the reflecting surfaces of the second plurality mainly extending along a plane and being spaced apart from each other in this plane to provide spaces therebetween, so that at least part of the scattered light rays can pass from the channel to the array of photodetectors by passing through said spaces between the reflecting surfaces of the second plurality of reflecting surfaces and without going through any reflecting surface of said second plurality. ∘ one channel for receiving at least one fluid comprising particles; ∘ one optical input configured to receive at least one incident light radiation; ∘ a first plurality of reflecting surfaces disposed between the optical input and the channel; ∘ an array of photodetectors facing the channel; ∘ a second plurality of reflecting surfaces disposed between the channel and the array of photodetectors and so that the channel is located between the first and second plurality of reflecting surfaces;
A sterile container for the storage and transport of medical utensils, having a fastening portion which is formed in one piece of material with a closed portion free of apertures of a container wall of the sterile container and to which an attachment part, which is manufactured from a sterilization-resistant material, can be fastened in a positive-locking manner or can be locked in place in a spring-elastic manner, wherein a wall thickness of the closed portion in the container wall is formed by the fastening portion and is substantially constant and equal to the wall thickness of the container wall bordering said portion.
A composition comprising: a) hyaluronic acid as a compound or salts thereof, and/or autologous cells reprogrammed to synthetize and secrete a compound, and b) des -IGF-I as an analogue of mammalian insulin-growth factor-1 having from 1 to 5 amino acid residues absent from the N-terminal. a) hyaluronic acid as a compound or salts thereof, and/or autologous cells reprogrammed to synthetize and secrete a compound, and b) des -IGF-I as an analogue of mammalian insulin-growth factor-1 having from 1 to 5 amino acid residues absent from the N-terminal.
A network node comprising means for quality of service based throttling in a fabric architecture in which the network node is one of a plurality of interconnected network nodes of the fabric architecture, the network node comprising: a processor (202, 204, 208, 210); a host fabric interface, HFI, configured to facilitate the transmission of data between the plurality of interconnected network nodes over an interconnect fabric of the fabric architecture; and one or more data storage devices having stored therein a plurality of instructions that, when executed by the processor, cause the network node to: monitor quality of service levels of the network node; and detect a throttling condition based on a result of the monitored quality of service levels, characterized in that the plurality of instructions cause the network node to: generate, in response to having detected the throttling condition, a throttling message based on a request type associated with the throttling condition detected; and transmit the generated throttling message to one or more of the plurality of interconnected network nodes communicatively coupled to the network node via the interconnect fabric. a processor (202, 204, 208, 210); a host fabric interface, HFI, configured to facilitate the transmission of data between the plurality of interconnected network nodes over an interconnect fabric of the fabric architecture; and one or more data storage devices having stored therein a plurality of instructions that, when executed by the processor, cause the network node to: monitor quality of service levels of the network node; and detect a throttling condition based on a result of the monitored quality of service levels, monitor quality of service levels of the network node; and detect a throttling condition based on a result of the monitored quality of service levels, characterized in that the plurality of instructions cause the network node to: generate, in response to having detected the throttling condition, a throttling message based on a request type associated with the throttling condition detected; and transmit the generated throttling message to one or more of the plurality of interconnected network nodes communicatively coupled to the network node via the interconnect fabric. generate, in response to having detected the throttling condition, a throttling message based on a request type associated with the throttling condition detected; and transmit the generated throttling message to one or more of the plurality of interconnected network nodes communicatively coupled to the network node via the interconnect fabric.
Disc filter, comprising a centrally arranged drum and at least one filter disc arranged on the drum, which filter disc comprises a plurality of filter segments projecting radially beyond the drum, which filter segments each have a closed filter frame with two radially projecting frame struts secured to the drum which are connected at the radially outer end via an arcuate connecting strut and have filter inserts mounted in the closed filter frame, characterized in that the filter frames are arranged on the drum at a distance from one another, forming a free space between adjacent filter frames and intermediate filter inserts are accommodated in each free space, and all filter inserts and intermediate filter inserts are covered on the outside with end profiles, which cover the filter inserts accommodated in the filter frames and the intermediate filter inserts and continue one another along a closed circular path, forming a cover ring.