A computer implemented method for identifying an extreme seizure event in a patient, comprising: determining at least one of an autonomic index, a neurologic index, a metabolic index, an endocrine index, or a tissue stress index, said at least one determined index being based upon body data; identifying a seizure event based upon said at least one determined index; determining at least one seizure severity index, SSI, value indicative of the severity of said seizure event based on the product of the duration of the seizure event determined as the time that any of the values of the autonomic index, neurologic index, metabolic index, endocrine index, or tissue stress index differ from inter-ictal and/or post-ictal values and the peak intensity of the seizure event defined by a maximum value of the body data; comparing said determined at least one SSI value to at least one extreme reference value, wherein the extreme reference value is a value above the ninetieth percentile of a plurality of past SSI values over a first time period; and identifying an occurrence of an extreme seizure event, based upon the comparison of said determined SSI value to said at least one extreme reference value; and wherein said extreme seizure event comprises at least one of a status epilepticus event or a pathophysiological effect resulting from an extreme epileptic state, the pathophysiological effect being selected from the group consisting of: damage to brain tissue resulting in permanent/serious motor/visual/sensory/cognitive skills; respiratory failure, cardiac failure, pulmonary edema, cardiac arrhythmia, arterial blood acidosis, liver/renal failure, bed sores, bone fractures, abrasions, bruises, organ failure, multi- organ failure, arterial hypertension, tissue hypoxia and tissue acidosis. determining at least one of an autonomic index, a neurologic index, a metabolic index, an endocrine index, or a tissue stress index, said at least one determined index being based upon body data; identifying a seizure event based upon said at least one determined index; determining at least one seizure severity index, SSI, value indicative of the severity of said seizure event based on the product of the duration of the seizure event determined as the time that any of the values of the autonomic index, neurologic index, metabolic index, endocrine index, or tissue stress index differ from inter-ictal and/or post-ictal values and the peak intensity of the seizure event defined by a maximum value of the body data; comparing said determined at least one SSI value to at least one extreme reference value, wherein the extreme reference value is a value above the ninetieth percentile of a plurality of past SSI values over a first time period; and identifying an occurrence of an extreme seizure event, based upon the comparison of said determined SSI value to said at least one extreme reference value; and wherein said extreme seizure event comprises at least one of a status epilepticus event or a pathophysiological effect resulting from an extreme epileptic state, the pathophysiological effect being selected from the group consisting of: damage to brain tissue resulting in permanent/serious motor/visual/sensory/cognitive skills; respiratory failure, cardiac failure, pulmonary edema, cardiac arrhythmia, arterial blood acidosis, liver/renal failure, bed sores, bone fractures, abrasions, bruises, organ failure, multi- organ failure, arterial hypertension, tissue hypoxia and tissue acidosis.