mhurhangee/ep-ind-claims huggingface dataset:
A method for the diagnosis or monitoring progress or reoccurrence of prostate cancer in a subject in need thereof, the method comprising the steps of: a. obtaining a random urine sample from a subject; b. extracting one or more mRNAs from the sample; c. detecting the level of mRNA expression of PCA3 and ERG; d. normalizing the level of mRNA expression of PCA3 and ERG to SPDEF; e. computing an output value for the normalized mRNA expression levels of PCA3 and ERG using the formula: log 2 max 1, E R G copies S P D E F copies + log 2 max 1, PCA 3 copies S P D E F copies + 16.92 ∗ 1.83 to generate an EXO106 Score; and f. comparing the EXO106 Score to a predetermined cutoff value that was determined using an ROC curve generated based on a combination of PCA3 and ERG to distinguish a subject at a high risk for prostate cancer from a subject with a low risk for prostate cancer, wherein the prostate cancer is a high Gleason score prostate cancer having a Gleason score greater than 6. a. obtaining a random urine sample from a subject; b. extracting one or more mRNAs from the sample; c. detecting the level of mRNA expression of PCA3 and ERG; d. normalizing the level of mRNA expression of PCA3 and ERG to SPDEF; e. computing an output value for the normalized mRNA expression levels of PCA3 and ERG using the formula: log 2 max 1, E R G copies S P D E F copies + log 2 max 1, PCA 3 copies S P D E F copies + 16.92 ∗ 1.83 to generate an EXO106 Score; and f. comparing the EXO106 Score to a predetermined cutoff value that was determined using an ROC curve generated based on a combination of PCA3 and ERG to distinguish a subject at a high risk for prostate cancer from a subject with a low risk for prostate cancer, wherein the prostate cancer is a high Gleason score prostate cancer having a Gleason score greater than 6.
A method for transferring a web wound about a loaded core comprising the steps of: providing a core shaft axially extending between a core shaft first end and a core shaft second end; providing a first web wound about a loaded first core, said loaded first core coaxially related to said core shaft; axially supporting said core shaft by a first axial support operatively engaged with said core shaft first end and a second axial support operatively engaged with said core shaft second end; axially moving said loaded first core from said core shaft to said second axial support; characterized by the step of removing said first axial support and said second axial support. providing a core shaft axially extending between a core shaft first end and a core shaft second end; providing a first web wound about a loaded first core, said loaded first core coaxially related to said core shaft; axially supporting said core shaft by a first axial support operatively engaged with said core shaft first end and a second axial support operatively engaged with said core shaft second end; axially moving said loaded first core from said core shaft to said second axial support; characterized by the step of removing said first axial support and said second axial support.
A triazole compound selected from Formula I or a pharmaceutically acceptable salt thereof for use in a method of reducing or preventing inflammation in a mammal, wherein X is N, O or S; each R 1 and each R 3 is independently selected from the group consisting of C 1-8 alkyl, amino, alkylamino, halogen, hydroxy, alkoxy, aryl, aryloxy, -CF 3, -OCF 3, -COR a, -COOR a, - CONR a R b, -NHCOR a R b, -NHSO 2 R a, -SO 2 R a, -SO 3 R a or -SO 2 NR a R b, wherein R a and R b are independently hydrogen, alkyl, cycloalkyl, aryl or aralkyl; R 2 is selected from the group consisting of H, C 1-6 alkyl, -COR a and -SO 2 R a; and R 4 is selected from the group consisting af C 1-8 alkyl, optionally substituted by at least one group selected from the group consisting of amino, alkylamino, halogen, hydroxy, alkoxy, -CF 3, -OCF 3, -COR a, -COOR a and -CONR a R b.
A method for determining functionality of an automatically closing door system (10, 10a), comprising the steps of: monitoring an obstruction signal output by an obstruction sensor (19, 19a) configured to detect an obstruction in a pathway of a door (12, 12a) of the door system (10, 10a), the obstruction signal corresponding to one of at least three states including a normal state, a first abnormal state and a second abnormal state, wherein the normal state corresponds to a toggle in the obstruction signal, the first abnormal state corresponds to a consistently active obstruction signal, and the second abnormal state corresponds to a consistently inactive obstruction signal; closing the door (12, 12a) at a first speed if the obstruction signal corresponds to the normal state; closing the door (12, 12a) at a second speed if the obstruction signal corresponds to any one of the first and second abnormal states (II, III), the second speed being slower than the first speed; monitoring a door position signal output by a position sensor (18, 18a) configured to detect a current position of the door (12, 12a), the door position signal corresponding to one of at least three states including a closed state, an open state and a blocked state; and declaring the door system (10, 10a) as malfunctioning if the obstruction signal corresponds to the first abnormal state and the door position signal corresponds to the closed state, or the obstruction signal corresponds to the second abnormal state and the door position signal corresponds to the blocked state. monitoring an obstruction signal output by an obstruction sensor (19, 19a) configured to detect an obstruction in a pathway of a door (12, 12a) of the door system (10, 10a), the obstruction signal corresponding to one of at least three states including a normal state, a first abnormal state and a second abnormal state, wherein the normal state corresponds to a toggle in the obstruction signal, the first abnormal state corresponds to a consistently active obstruction signal, and the second abnormal state corresponds to a consistently inactive obstruction signal; closing the door (12, 12a) at a first speed if the obstruction signal corresponds to the normal state; closing the door (12, 12a) at a second speed if the obstruction signal corresponds to any one of the first and second abnormal states (II, III), the second speed being slower than the first speed; monitoring a door position signal output by a position sensor (18, 18a) configured to detect a current position of the door (12, 12a), the door position signal corresponding to one of at least three states including a closed state, an open state and a blocked state; and declaring the door system (10, 10a) as malfunctioning if the obstruction signal corresponds to the first abnormal state and the door position signal corresponds to the closed state, or the obstruction signal corresponds to the second abnormal state and the door position signal corresponds to the blocked state.
A pharmaceutical composition having ciclopirox or ciclopirox olamine or a ciclopirox-POM prodrug having a structure of Formula 1 or stereoisomer thereof or pharmaceutically acceptable salt thereof for use in the treatment of bladder cancer, wherein and wherein: R 1 -R 12 each independently include one or more of hydrogen, halogens, hydroxyls, alkoxys, straight aliphatics, branched aliphatics, cyclic aliphatics, substituted aliphatics, unsubstituted aliphatics, saturated aliphatics, unsaturated aliphatics, aromatics, polyaromatics, substituted aromatics, hetero-aromatics, amines, primary amines, secondary amines, tertiary amines, aliphatic amines, carbonyls, carboxyls, amides, esters, amino acids, peptides, polypeptides, substituted or unsubstituted, or combinations thereof; R 13 -R 14 each independently include one or more of a positive ion, sodium ion, hydrogen, halogens, hydroxyls, alkoxys, straight aliphatics, branched aliphatics, cyclic aliphatics, substituted aliphatics, unsubstituted aliphatics, saturated aliphatics, unsaturated aliphatics, aromatics, polyaromatics, substituted aromatics, hetero-aromatics, amines, primary amines, secondary amines, tertiary amines, aliphatic amines, carbonyls, carboxyls, amides, esters, amino acids, peptides, polypeptides, substituted or unsubstituted, or combinations thereof; n is 0-20 substituted or unsubstituted; and m is 0, 1 or 2. R 1 -R 12 each independently include one or more of hydrogen, halogens, hydroxyls, alkoxys, straight aliphatics, branched aliphatics, cyclic aliphatics, substituted aliphatics, unsubstituted aliphatics, saturated aliphatics, unsaturated aliphatics, aromatics, polyaromatics, substituted aromatics, hetero-aromatics, amines, primary amines, secondary amines, tertiary amines, aliphatic amines, carbonyls, carboxyls, amides, esters, amino acids, peptides, polypeptides, substituted or unsubstituted, or combinations thereof; R 13 -R 14 each independently include one or more of a positive ion, sodium ion, hydrogen, halogens, hydroxyls, alkoxys, straight aliphatics, branched aliphatics, cyclic aliphatics, substituted aliphatics, unsubstituted aliphatics, saturated aliphatics, unsaturated aliphatics, aromatics, polyaromatics, substituted aromatics, hetero-aromatics, amines, primary amines, secondary amines, tertiary amines, aliphatic amines, carbonyls, carboxyls, amides, esters, amino acids, peptides, polypeptides, substituted or unsubstituted, or combinations thereof; n is 0-20 substituted or unsubstituted; and m is 0, 1 or 2.
Electro-pneumatic assembly, particularly for a pneumatic braking installation of a railway vehicle or train, comprising a body wherein a chamber is defined, a solenoid supply valve adapted for selectively coupling said chamber to a pressure source (P s) or the atmosphere, a solenoid vent or discharge valve adapted to allow and selectively prevent the connection of said chamber to the atmosphere; said solenoid valves (12, 13) being provided with respective control solenoids (12a, 13a) to which respective electronic switches (19, 20; 19, 119; 20, 120) are coupled; and electronic control means (16, 116; 1016) adapted to provide, as a function of the values of at least one input signal (L, P), logic control signals to said electronic switches (19, 119; 20, 120) such as to control, through said solenoid valves (12, 13), the value of the pressure in said chamber; the electro-pneumatic assembly being characterized in that said electronic control means comprise first and second electronic processing and control devices (16; 116) independent of one another, both receiving said at least one input signal (L, P) and designed to execute strategies for controlling the pressure in said chamber, equivalent to one another; said first and second electronic processing and control devices (16; 116) each being coupled to the control solenoids (12a, 13a) of the solenoid supply valve and the solenoid vent valve through respective first (19, 20) and second (119, 120) electronic switches; the first electronic switches (19, 20) and the second electronic switches (119, 120) respectively associated with said first and second electronic processing and control device (16; 116) being coupled to one another in a predetermined manner, so as to form together an enabling logic circuit (19, 20; 119, 120) designed to drive the solenoids (12a, 13a) of said solenoid valves (12, 13) in such a way that when the logic control signals provided by said first and second electronic processing and control device (16; 116) conflict with one another, the logic control signals that are actuated are those supplied by the electronic processing and control device which tends to produce in said chamber a pressure whose value complies with a predetermined relationship compared with the value which would be produced as a result of the logic control signals supplied by the other electronic processing and control device.
Apparatus for a heating device for a vehicle, comprising a layer stack which, in a stacking direction, has: - a heating conductor layer, - an electrically conductive layer which forms a contact region, wherein a contour in a projection in the stacking direction of the electrically conductive layer is prespecified, in order to prevent a hotspot on the electrically conductive layer, wherein the contour is prespecified by a prespecified distance from a joint of the heating conductor layer, characterized in that a front side of the electrically conductive layer, which front side faces a central region of the heating conductor layer, has two convex sections which are each curved in the direction of the current flow which occurs during operation. - a heating conductor layer, - an electrically conductive layer which forms a contact region, wherein a contour in a projection in the stacking direction of the electrically conductive layer is prespecified, in order to prevent a hotspot on the electrically conductive layer, wherein the contour is prespecified by a prespecified distance from a joint of the heating conductor layer, characterized in that a front side of the electrically conductive layer, which front side faces a central region of the heating conductor layer, has two convex sections which are each curved in the direction of the current flow which occurs during operation.
Escape ramp for a passenger rail car, which, in a rest position, is arranged below the emergency exit of the passenger rail car and in an operating position permits the evacuation of people from the passenger rail car, characterised in that the emergency ramp has a frame made from at least two partial frames and these partial frames are arranged in a manner so as to be able to slide into one another, and a tread surface is provided which, in an operating position of the escape ramp, forms a passable surface, and wherein - the tread surface is manufactured from a flexible material and is rolled when the escape ramp is in a rest position, or wherein - the tread surface is folded when the escape ramp is in the rest position. - the tread surface is manufactured from a flexible material and is rolled when the escape ramp is in a rest position, or wherein - the tread surface is folded when the escape ramp is in the rest position.
A composition, comprising: a continuous water phase, a discontinuous oil phase substantially homogeneously distributed in said water phase, said oil phase comprising a sunscreen agent comprising a UV-absorbing polyester in an amount effective to provide said composition with an SPF of about 10 or greater, which UV-absorbing polyester is the polymerization reaction product of monomers comprising a UV-absorbing triazole, a diester, a diol and a tetrol polyol, an alkylated polyvinylpyrrolidone; and an oil-in-water emulsifier selected from the group consisting of an anionic emulsifier and a non-ionic emulsifier, wherein said composition is substantially free of a non-polymeric UV-absorbing sunscreen agent and has an SPF of less than 2 in the absence of said UV-absorbing polyester. a continuous water phase, a discontinuous oil phase substantially homogeneously distributed in said water phase, said oil phase comprising a sunscreen agent comprising a UV-absorbing polyester in an amount effective to provide said composition with an SPF of about 10 or greater, which UV-absorbing polyester is the polymerization reaction product of monomers comprising a UV-absorbing triazole, a diester, a diol and a tetrol polyol, an alkylated polyvinylpyrrolidone; and an oil-in-water emulsifier selected from the group consisting of an anionic emulsifier and a non-ionic emulsifier,
A method of controlling a wave energy conversion system that converts the energy of waves to electrical or hydraulic energy, said wave energy conversion system comprising at least one mobile means that cooperates with at least one energy converter machine, and said mobile means having an oscillating motion with respect to said converter machine, characterized in that the following steps are carried out: a) constructing a dynamic model of said wave energy conversion system relating the velocity of said mobile means to said force exerted by waves on said mobile means and to the force exerted by said converter machine on said mobile means, b) constructing an energy model of said wave energy conversion system relating the average power generated by said converter machine to the force exerted by said converter machine on said mobile means, to the velocity of said mobile means and to the efficiency of the energy conversion means, c) predicting the force exerted by waves on said mobile means for a predetermined time period, d) determining a control value of said force exerted by said converter machine on said mobile means maximizing the average power generated by said converter machine, by means of said prediction of the force exerted by waves on said mobile means, of said dynamic model and of said energy model, and e) controlling said converter machine by means of said control value. a) constructing a dynamic model of said wave energy conversion system relating the velocity of said mobile means to said force exerted by waves on said mobile means and to the force exerted by said converter machine on said mobile means, b) constructing an energy model of said wave energy conversion system relating the average power generated by said converter machine to the force exerted by said converter machine on said mobile means, to the velocity of said mobile means and to the efficiency of the energy conversion means, c) predicting the force exerted by waves on said mobile means for a predetermined time period, d) determining a control value of said force exerted by said converter machine on said mobile means maximizing the average power generated by said converter machine, by means of said prediction of the force exerted by waves on said mobile means, of said dynamic model and of said energy model, and e) controlling said converter machine by means of said control value.
A dosing machine for dosing fluid products, comprising: - a plurality of containers having respective vertical longitudinal axes, configured to contain respective fluid products, - a plurality of rotary stirring elements located inside respective containers and operable in rotation by respective electric motors, and - a dispensing head having a plurality of nozzles connected to respective containers, characterized in that each of said containers is associated with a respective level measuring device comprising: - a floater containing a permanent magnet and arranged inside the respective container, wherein the floater is free to move inside the container and, during operation, is moved around the vertical longitudinal axis of the container by the respective stirring element, - a magnetic detector arranged outside the container and comprising a plurality of magnetic sensors spaced apart from each other in a vertical direction and each of which is configured to detect a variation in the magnetic field caused by the passage of said floater in its proximity, and - a control unit which analyzes the signals provided by said plurality of magnetic sensors to detect the level of the fluid inside the container, and the periodic passage of the floater in the vicinity of one or more of said magnetic sensors. - a plurality of containers having respective vertical longitudinal axes, configured to contain respective fluid products, - a plurality of rotary stirring elements located inside respective containers and operable in rotation by respective electric motors, and - a dispensing head having a plurality of nozzles connected to respective containers, - a floater containing a permanent magnet and arranged inside the respective container, wherein the floater is free to move inside the container and, during operation, is moved around the vertical longitudinal axis of the container by the respective stirring element, - a magnetic detector arranged outside the container and comprising a plurality of magnetic sensors spaced apart from each other in a vertical direction and each of which is configured to detect a variation in the magnetic field caused by the passage of said floater in its proximity, and - a control unit which analyzes the signals provided by said plurality of magnetic sensors to detect the level of the fluid inside the container, and the periodic passage of the floater in the vicinity of one or more of said magnetic sensors.
An organic electroluminescence device comprising opposite anode and cathode, and a hole-transporting region, an emitting layer and an electron-transporting region In sequential order from the anode between the anode and the cathode, the emitting layer comprising a red emitting portion, a green emitting portion, and a blue emitting portion; the blue emitting portion comprising a host BH and a fluorescent dopant FBD; and the green emitting portion comprising a host GH and a phosphorescent dopant PGD; the organic electroluminescent device being characterized In that the triplet energy E T fbd of the fluorescent dopant FBD is larger than the triplet energy E T bh of the host BH; the electron-transporting region comprises a common electron-transporting layer adjacent to the red emitting portion, the green emitting portion and the blue emitting portion; the common electron-transporting layer comprises a material having a triplet energy E T el larger than E T bh; the hole-transporting region comprises a hole-transporting layer adjacent to the blue-emitting portion; the hole-transporting layer comprises a material having a triplet energy E T ho larger than E T h of the host of the blue emitting portion; and the difference between the electron affinity of the host GH and the electron affinity of the material constituting the common electron-transporting layer is 0.4 eV or less.
Device for the electrical heating of liquid (Liq), comprising: - a first tube made from electrically conductive material forming a resistor, - two electrical connections (30, 31) each fitted in one of the ends of the resistor, the electrical connections being adapted to bring a direct current through the resistor and to make it emerge respectively, - an intermediate element (6, 22), made from material that is both thermally conductive and electrically insulating, surrounding, with direct mechanical contact, respectively the resistor and the two electrical connections over at least part of their length, - a second tube forming a sheath, made from thermally conductive material and surrounding the thermally conductive intermediate element with direct mechanical contact, the sheath being intended to be immersed, over at least a major part of its length, in the liquid to be heated. - a first tube made from electrically conductive material forming a resistor, - two electrical connections (30, 31) each fitted in one of the ends of the resistor, the electrical connections being adapted to bring a direct current through the resistor and to make it emerge respectively, - an intermediate element (6, 22), made from material that is both thermally conductive and electrically insulating, surrounding, with direct mechanical contact, respectively the resistor and the two electrical connections over at least part of their length, - a second tube forming a sheath, made from thermally conductive material and surrounding the thermally conductive intermediate element with direct mechanical contact, the sheath being intended to be immersed, over at least a major part of its length, in the liquid to be heated.