A system comprising: a blood fluid removal device comprising (i) an inlet for receiving blood from a patient, (ii) a first outlet for returning blood to the patient, (iii) a medium for removing fluid and contaminants from the blood in a blood compartment of the patient, the medium being positioned between the inlet and the first outlet, wherein removal of fluid from the blood causes a flow of fluid from a tissue compartment of the patient to the blood compartment of the patient; (iv) a fluid rate removal controller; and (v) a second outlet for flow of the removed fluid and contaminants; a first sensor at a first location for monitoring tissue fluid in the tissue compartment of the patient for an indicator of tissue fluid volume; a second sensor at a second, different location for monitoring blood fluid in the blood compartment of the patient for an indicator of blood fluid volume; control electronics in operable communication with the sensor for monitoring an indicator of tissue fluid volume, the sensor for monitoring an indicator of blood fluid volume; and the fluid rate removal controller; and a computer readable medium comprising instructions that cause the control electronics to determine a ratio of tissue fluid volume and blood fluid volume from data obtained from the first sensor and the second sensor, to adjust the rate at which fluid is removed based on the ratio. a blood fluid removal device comprising (i) an inlet for receiving blood from a patient, (ii) a first outlet for returning blood to the patient, (iii) a medium for removing fluid and contaminants from the blood in a blood compartment of the patient, the medium being positioned between the inlet and the first outlet, wherein removal of fluid from the blood causes a flow of fluid from a tissue compartment of the patient to the blood compartment of the patient; (iv) a fluid rate removal controller; and (v) a second outlet for flow of the removed fluid and contaminants; (i) an inlet for receiving blood from a patient, (ii) a first outlet for returning blood to the patient, (iii) a medium for removing fluid and contaminants from the blood in a blood compartment of the patient, the medium being positioned between the inlet and the first outlet, wherein removal of fluid from the blood causes a flow of fluid from a tissue compartment of the patient to the blood compartment of the patient; (iv) a fluid rate removal controller; and (v) a second outlet for flow of the removed fluid and contaminants; a first sensor at a first location for monitoring tissue fluid in the tissue compartment of the patient for an indicator of tissue fluid volume; a second sensor at a second, different location for monitoring blood fluid in the blood compartment of the patient for an indicator of blood fluid volume; control electronics in operable communication with the sensor for monitoring an indicator of tissue fluid volume, the sensor for monitoring an indicator of blood fluid volume; and the fluid rate removal controller; and a computer readable medium comprising instructions that cause the control electronics to determine a ratio of tissue fluid volume and blood fluid volume from data obtained from the first sensor and the second sensor, to adjust the rate at which fluid is removed based on the ratio.