A compound of Formula or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, phenyl, 5-10 membered heteroaryl, 5-9 membered heterocycloalkyl, (C 1 -C 3 alkylene)-(C 3 -C 6 cycloalkyl), (C 1 -C 3 alkylene)-phenyl, (C 1 -C 3 haloalkylene)-phenyl, (C 1 -C 3 alkylene)-(5-10 membered heteroaryl), (C 1 -C 3 alkylene)-(5-9 membered heterocycloalkyl), (C 1 -C 3 alkylene)-O-(C 3 -C 6 cycloalkyl), and (C 1 -C 3 alkylene)-NH-(C 3 -C 6 cycloalkyl), wherein the alkyl, alkylene, cycloalkyl, phenyl, heteroaryl, and heterocycloalkyl are each optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -NH 2, C 1 -C 3 alkyl, (C 1 -C 3 haloalkyl), (C 3 -C 6 cycloalkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-O-(C 1 -C 3 alkyl), and phenyl; R 2 is selected from 4-6 membered heterocycloalkyl, (C 1 -C 3 alkylene)-(4-10 membered heterocycloalkyl), and (C 1 -C 3 alkylene)-NR 2A R 2B, wherein the alkylene and heterocycloalkyl are each optionally substituted with one or more substituents independently selected from halogen, oxo, -OH, (C 1 -C 3 alkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-C OH, -C H, -C OH, -C (C 1 -C 3 alkyl), -C (C 1 -C 3 alkylene)-OH, -C C OH, and -SO 2 (C 1 -C 3 alkyl); R 2A and R 2B are each independently selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 3 -C 6 cycloalkyl, (C 1 -C 3 alkylene)-O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-OH, (C 1 -C 3 alkylene)-(C 3 -C 6 cycloalkyl), (C 1 -C 3 alkylene)-S(=O)-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-SO 2 (C 1 -C 3 alkyl), and C(=NH)(C 1 -C 3 alkyl); or R 2A and R 2B, taken together with the nitrogen to which they are attached, form a 3-9 membered heterocycloalkyl ring optionally substituted with one or more substituents independently selected from halogen, oxo, -OH, C 1 -C 3 alkyl, (C 1 -C 3 haloalkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-C OH, -C H, -C (C 1 -C 3 alkyl), -C (C 1 -C 3 alkylene)-OH, -C C OH, and -SO 2 (C 1 -C 3 alkyl), and optionally containing one additional heteroatom selected from the group of N, O, and S; R 3 and R 4 are each independently selected from H, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 5 is selected from H and C 1 -C 6 alkyl. R 1 is selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, phenyl, 5-10 membered heteroaryl, 5-9 membered heterocycloalkyl, (C 1 -C 3 alkylene)-(C 3 -C 6 cycloalkyl), (C 1 -C 3 alkylene)-phenyl, (C 1 -C 3 haloalkylene)-phenyl, (C 1 -C 3 alkylene)-(5-10 membered heteroaryl), (C 1 -C 3 alkylene)-(5-9 membered heterocycloalkyl), (C 1 -C 3 alkylene)-O-(C 3 -C 6 cycloalkyl), and (C 1 -C 3 alkylene)-NH-(C 3 -C 6 cycloalkyl), wherein the alkyl, alkylene, cycloalkyl, phenyl, heteroaryl, and heterocycloalkyl are each optionally substituted with one or more substituents independently selected from halogen, - CN, -OH, -NH 2, C 1 -C 3 alkyl, (C 1 -C 3 haloalkyl), (C 3 -C 6 cycloalkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-O-(C 1 -C 3 alkyl), and phenyl; R 2 is selected from 4-6 membered heterocycloalkyl, (C 1 -C 3 alkylene)-(4-10 membered heterocycloalkyl), and (C 1 -C 3 alkylene)-NR 2A R 2B, wherein the alkylene and heterocycloalkyl are each optionally substituted with one or more substituents independently selected from halogen, oxo, -OH, (C 1 -C 3 alkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-C OH, -C H, -C OH, -C (C 1 -C 3 alkyl), -C (C 1 -C 3 alkylene)-OH, -C C OH, and -SO 2 (C 1 -C 3 alkyl); R 2A and R 2B are each independently selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 3 -C 6 cycloalkyl, (C 1 -C 3 alkylene)-O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-OH, (C 1 -C 3 alkylene)-(C 3 -C 6 cycloalkyl), (C 1 -C 3 alkylene)-S(=O)-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-SO 2 (C 1 -C 3 alkyl), and C(=NH)(C 1 -C 3 alkyl); or R 2A and R 2B, taken together with the nitrogen to which they are attached, form a 3-9 membered heterocycloalkyl ring optionally substituted with one or more substituents independently selected from halogen, oxo, -OH, C 1 -C 3 alkyl, (C 1 -C 3 haloalkyl), -O-(C 1 -C 3 alkyl), (C 1 -C 3 alkylene)-C OH, -C H, -C (C 1 -C 3 alkyl), -C (C 1 -C 3 alkylene)-OH, -C C OH, and -SO 2 (C 1 -C 3 alkyl), and optionally containing one additional heteroatom selected from the group of N, O, and S; R 3 and R 4 are each independently selected from H, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 5 is selected from H and C 1 -C 6 alkyl.