mhurhangee/ep-ind-claims huggingface dataset:
A method for large-scale expansion and simultaneous activation of natural killer cells with the phenotype CD3 - CD56 + and NK-like T cells with the phenotype CD3 + CD56 +, wherein said expansion and activation is performed in a closed system, and the expanded cells obtained exhibit an increased cytotoxicity as determined by an in vitro cytotoxicity test, said method comprising: (i) providing cells from a sample of peripheral blood from a tumour bearing subject; (ii) adding the cells to a closed cell culture bag bioreactor at a concentration of about 0.5 x 10 6 to about 2 x 10 6 /ml of cell growth medium supplemented with serum, interleukin 2 (IL-2) and anti-CD3 antibodies; (iii) incubating and expanding the cells of step ii) with rocking motion agitation and heating until at least 50% of the expanded cell population comprises activated NK cells and NK-like T cells; and (iv) harvesting said expanded cell suspension of activated NK cells and NK-like T cells from said bioreactor, wherein said cells exhibit an increased cytotoxicity compared to freshly isolated cells as determined by an in vitro cytotoxicity test. (i) providing cells from a sample of peripheral blood from a tumour bearing subject; (ii) adding the cells to a closed cell culture bag bioreactor at a concentration of about 0.5 x 10 6 to about 2 x 10 6 /ml of cell growth medium supplemented with serum, interleukin 2 (IL-2) and anti-CD3 antibodies; (iii) incubating and expanding the cells of step ii) with rocking motion agitation and heating until at least 50% of the expanded cell population comprises activated NK cells and NK-like T cells; and (iv) harvesting said expanded cell suspension of activated NK cells and NK-like T cells from said bioreactor, wherein said cells exhibit an increased cytotoxicity compared to freshly isolated cells as determined by an in vitro cytotoxicity test.
A fan drive gear system for a gas turbine engine, comprising: a torque frame having an arm extending therefrom, the arm providing an axis, wherein the arm has an outer surface that forms a bias angle with respect to the axis of the arm; a journal bearing mounted on the arm and having an outer circumferential surface, a main body having an inner radial surface that interfaces with the arm, a first wing extending from a first side of the main body, and a second wing extending from a second opposing side of the main body, the first and second wings being asymmetric with respect to one another; wherein the angle of the outer surface of the journal bearing is substantially the same as the bias angle of the outer surface of the arm; a planet gear supported on the journal bearing for rotation about a rotational axis which substantially aligns with and is parallel to the axis of the arm; a sun gear located radially inward from and intermeshing with the planet gear, the sun gear coupled to a low pressure shaft of the gas turbine engine; and a ring gear arranged about and intermeshing with the planet gear, the ring gear coupled to a fan shaft of the gas turbine engine; wherein when the fan drive gear system is in an unloaded condition the outer circumferential surface of the journal bearing is disposed at an angle that is non-parallel with respect to the axis of the arm, and wherein when the fan drive gear system is in a loaded condition the outer circumferential surface of the journal bearing is disposed substantially parallel with respect to the axis of the arm. a torque frame having an arm extending therefrom, the arm providing an axis, wherein the arm has an outer surface that forms a bias angle with respect to the axis of the arm; a journal bearing mounted on the arm and having an outer circumferential surface, a main body having an inner radial surface that interfaces with the arm, a first wing extending from a first side of the main body, and a second wing extending from a second opposing side of the main body, the first and second wings being asymmetric with respect to one another; wherein the angle of the outer surface of the journal bearing is substantially the same as the bias angle of the outer surface of the arm; a planet gear supported on the journal bearing for rotation about a rotational axis which substantially aligns with and is parallel to the axis of the arm; a sun gear located radially inward from and intermeshing with the planet gear, the sun gear coupled to a low pressure shaft of the gas turbine engine; and a ring gear arranged about and intermeshing with the planet gear, the ring gear coupled to a fan shaft of the gas turbine engine; wherein when the fan drive gear system is in an unloaded condition the outer circumferential surface of the journal bearing is disposed at an angle that is non-parallel with respect to the axis of the arm, and wherein when the fan drive gear system is in a loaded condition the outer circumferential surface of the journal bearing is disposed substantially parallel with respect to the axis of the arm.
A steel pipe having excellent expandability, characterized in that the steel pipe has a steel composition comprising, by mass%, C: 0.1 to 0.45%, Si: 0.3 to 3.5%, Mn: 0.5 to 5%, P: less than or equal to 0.03%, S: less than or equal to 0.01%, soluble Al: 0.2 to 0.8%, N: less than or equal to 0.05%, O: less than or equal to 0.01%, and optionally at least one element selected from at least one of Groups to specified below, and balance being Fe and impurities, wherein the steel has a mixed microstructure comprising ferrite and one or more selected from fine pearlite, bainite and martensite, and the steel has a tensile strength of 600MPa or more and a uniform elongation satisfying the following formula: u-el ≧ 28 − 0.0075 ⁢ TS wherein u-el means uniform elongation (%), and TS means tensile strength (MPa): wherein Group of elements is; Cr: less than or equal to 1.5% and Cu: less than or equal to 3.0%; wherein Group of elements is; Mo: less than or equal to 1%; wherein Group of elements is; Ni: less than or equal to 2%; wherein Group of elements is; Ti: less than or equal to 0.3%, Nb: less than or equal to 0.3%, V: less than or equal to 0.3%, Zr: less than or equal to 0.3%, and B: less than or equal to 0.01%; wherein Group of elements is: Ca: less than or equal to 0.01%, Mg: less than or equal to 0.01%, and REM: less than or equal to 1.0%. wherein Group of elements is; Cr: less than or equal to 1.5% and Cu: less than or equal to 3.0%; wherein Group of elements is; Mo: less than or equal to 1%; wherein Group of elements is; Ni: less than or equal to 2%; wherein Group of elements is; Ti: less than or equal to 0.3%, Nb: less than or equal to 0.3%, V: less than or equal to 0.3%, Zr: less than or equal to 0.3%, and B: less than or equal to 0.01%; wherein Group of elements is: Ca: less than or equal to 0.01%, Mg: less than or equal to 0.01%, and REM: less than or equal to 1.0%.
Process for preparing pimecrolimus, characterised in that it comprises an enzymatic acylation step and an enzymatic alcoholysis step with lipase from Candida antartica, according to the following steps: a) selective enzymatic acylation of the hydroxyl in position 33 of ascomycin with lipase from Candida antartica, in the presence of an acylating agent and an organic solvent; b) conversion of the 33-acylated derivative thus obtained in the corresponding 24- tert -butyl-dimethyl-silyl ether, with a silylating agent in the presence of an organic base; c) enzymatic removal with lipase from Candida antartica of the acyl in position 33 of the compound prepared in step b), in the presence an organic solvent and a C 1 -C 8 primary aliphatic alcohol, obtaining 24- tert -butyl-dimethyl-silyl ether of ascomycin. a) selective enzymatic acylation of the hydroxyl in position 33 of ascomycin with lipase from Candida antartica, in the presence of an acylating agent and an organic solvent; b) conversion of the 33-acylated derivative thus obtained in the corresponding 24- tert -butyl-dimethyl-silyl ether, with a silylating agent in the presence of an organic base; c) enzymatic removal with lipase from Candida antartica of the acyl in position 33 of the compound prepared in step b), in the presence an organic solvent and a C 1 -C 8 primary aliphatic alcohol, obtaining 24- tert -butyl-dimethyl-silyl ether of ascomycin.
An array speaker, comprising: an axisymmetric device housing; audio driver assemblies distributed radially about and defining a recess within an interior of the axisymmetric device housing, each of the audio driver assemblies including a diaphragm arranged to generate audio waves initially oriented toward the recess; and a power supply unit suspended above and coupled to supply power to the audio driver assemblies, a portion of the power supply unit extends into the recess defined by the audio driver assemblies. an axisymmetric device housing; audio driver assemblies distributed radially about and defining a recess within an interior of the axisymmetric device housing, each of the audio driver assemblies including a diaphragm arranged to generate audio waves initially oriented toward the recess; and a power supply unit suspended above and coupled to supply power to the audio driver assemblies, a portion of the power supply unit extends into the recess defined by the audio driver assemblies.
A production method of foodstuffs and pharmaceuticals comprising, in order, the steps of: a) jetting a radiation curable inkjet ink having a viscosity smaller than 30 mPa.s at 25°C and at a shear rate of 1,000 s -1 on a polymeric surface of a packaging material; b) curing the radiation curable inkjet ink on the polymeric surface of the packaging material; and c) heat sterilization of the packaging material; wherein the polymeric surface is the outside surface of a packaging material for including a substance for human or animal consumption or administration; and wherein the radiation curable inkjet ink includes a vinyl ether acrylate and a photoinitiator selected from the group consisting of non-polymeric multifunctional photoinitiators, oligomeric or polymeric photoinitiators and polymerizable photoinitiators. a) jetting a radiation curable inkjet ink having a viscosity smaller than 30 mPa.s at 25°C and at a shear rate of 1,000 s -1 on a polymeric surface of a packaging material; b) curing the radiation curable inkjet ink on the polymeric surface of the packaging material; and c) heat sterilization of the packaging material;
A method for the reductive amination of a carbonyl compound, comprising one or more carbonyl groups amenable to reductive amination, wherein the reaction is carried out in the presence of a homogeneously dissolved catalyst K and an acid as co-catalyst, wherein the catalyst K is a ruthenium catalyst which comprises a bidentate phosphane ligand, a carbonyl ligand, a hydride ligand and optionally a neutral ligand.
A method of monitoring switching by an on-load tap changer, OLTC, from a first contact to a second contact of a transformer winding during a switching time period, the method comprising: measuring a phase voltage of the transformer over time; measuring a temperature of the OLTC over time; based on the measured voltage and temperature, determining that the switching from the first contact to the second contact has not been successful; wherein the determining comprises determining that the measured voltage has changed during the switching time period and that the change is above a predetermined threshold; and wherein the determining comprises determining that the measured temperature continues to rise after the end of the switching time period. measuring a phase voltage of the transformer over time; measuring a temperature of the OLTC over time; based on the measured voltage and temperature, determining that the switching from the first contact to the second contact has not been successful; wherein the determining comprises determining that the measured voltage has changed during the switching time period and that the change is above a predetermined threshold; and wherein the determining comprises determining that the measured temperature continues to rise after the end of the switching time period.
A portable electronic device (200, 600), comprising: an electronic device housing (202, 602) including a bottom surface and side surfaces; a translucent cover (208, 608) for a top surface for the electronic device housing, the translucent cover having a bottom surface; at least one mounting bracket (214, 614) secured to a peripheral region of the bottom surface of the translucent cover, wherein the at least one mounting bracket is positioned below the translucent cover a screen assembly (210, 610) having a top surface, a bottom surface, and a sensing layer, the top surface being secured to a central region of the bottom surface of the translucent cover; and at least one frame (218, 614) secured within the electronic device housing such that the at least one frame is adjacent the bottom surface of the screen assembly, characterised in that the mounting bracket is positioned only within the peripheral region of the bottom surface of the translucent cover. an electronic device housing (202, 602) including a bottom surface and side surfaces; a translucent cover (208, 608) for a top surface for the electronic device housing, the translucent cover having a bottom surface; at least one mounting bracket (214, 614) secured to a peripheral region of the bottom surface of the translucent cover, wherein the at least one mounting bracket is positioned below the translucent cover a screen assembly (210, 610) having a top surface, a bottom surface, and a sensing layer, the top surface being secured to a central region of the bottom surface of the translucent cover; and at least one frame (218, 614) secured within the electronic device housing such that the at least one frame is adjacent the bottom surface of the screen assembly, characterised in that the mounting bracket is positioned only within the peripheral region of the bottom surface of the translucent cover.
Device for measuring contractions and/or the relaxation of one or several muscles of a body cavity, said device comprising a hollow body which is for positioning in said body cavity, and which is covered by a coating made of, or comprising, a biocompatible material, said body being formed by two half-shells (7 and 8) which are each physically connected, permanently and continuously during the use of said device, using non-compressible or deformable connecting means, to at least one pressure sensor, or part of said pressure sensor, arranged in said body.
Printing plate cylinder of a flexographic printing press, with a cylinder core which is rotatably mounted in the printing press, with a sleeve displaceable on the cylinder core, wherein the sleeve is displaceable in the axial direction (z) and in the circumferential direction (φ) with respect to the cylinder core, wherein the cylinder core comprises a stop which the sleeve reaches at its end position in the axial direction (z), and wherein the sleeve is displaceable in its circumferential direction (φ) to its reference position when it reaches its end position in the axial direction (z), with a register element, which is part of the cylinder core, and with a counterpart to this register element which is a component of the sleeve, wherein the register element is pivotally mounted on the cylinder core or the counterpart is pivotally mounted on the sleeve in such a manner, that there is a form fit between the register element and the counterpart, when the cylinder core and the sleeve are in their reference position with respect to each other.
An apparatus for backscattering an incoming radio frequency signal transmitted at a carrier frequency, the apparatus comprising: an antenna configured for emitting a backscattered radio frequency signal responsive to the incoming RF signal in accordance with an adjustable reflection coefficient of the antenna; a variable impedance circuit having a switchable impedance element in parallel with a fixed impedance element, wherein the switchable impedance element has a control input for switching the switchable impedance element between (i) a control-on state in which the switchable impedance element has a null impedance notch response at the carrier frequency and a high impedance response at all other frequencies and (ii) a control-off state in which the switchable impedance element has a high impedance response at all frequencies, wherein the variable impedance circuit further has a variable impedance circuit output electrically connected to the antenna for adjusting the adjustable reflection coefficient of the antenna; and a low pass delta sigma modulator having (i) a delta sigma modulator input for receiving a delta sigma modulator input signal and (ii) a delta sigma modulator output coupled to the control input of the switchable impedance element of the variable impedance circuit; wherein the reflection coefficient of the antenna is adjusted based on the output of the variable impedance circuit. an antenna configured for emitting a backscattered radio frequency signal responsive to the incoming RF signal in accordance with an adjustable reflection coefficient of the antenna; a variable impedance circuit having a switchable impedance element in parallel with a fixed impedance element, wherein the switchable impedance element has a control input for switching the switchable impedance element between (i) a control-on state in which the switchable impedance element has a null impedance notch response at the carrier frequency and a high impedance response at all other frequencies and (ii) a control-off state in which the switchable impedance element has a high impedance response at all frequencies, wherein the variable impedance circuit further has a variable impedance circuit output electrically connected to the antenna for adjusting the adjustable reflection coefficient of the antenna; and a low pass delta sigma modulator having (i) a delta sigma modulator input for receiving a delta sigma modulator input signal and (ii) a delta sigma modulator output coupled to the control input of the switchable impedance element of the variable impedance circuit; wherein the reflection coefficient of the antenna is adjusted based on the output of the variable impedance circuit.
An operation assisting tool comprising: a gripper; and an engagement portion to engage with a handle of a drawer (12, 12a) drawable from a housing of an image forming apparatus, wherein the engagement portion has a first counter face and a second counter face to face a pair of faces (12b1, 12b2) of the handle that are orthogonal to a moving direction of the drawer (12, 12a), wherein the first counter face of the engagement portion is to face downstream one (12b1) of the pair of faces (12b1, 12b2) of the handle in the moving direction, wherein the second counter face of the engagement portion is to face upstream one (12b2) of the pair of faces (12b1, 12b2) of the handle in the moving direction, and wherein the engagement portion has an opening to which the handle is to be inserted, characterized in that the first counter face has a first protrusion protruding toward the second counter face, the second counter face has a second protrusion protruding toward the first counter face, and each of the first protrusion and the second protrusion is disposed at a position lower than the position of the handle when the operation assisting tool is attached to the handle. a gripper; and an engagement portion to engage with a handle of a drawer (12, 12a) drawable from a housing of an image forming apparatus, wherein the engagement portion has a first counter face and a second counter face to face a pair of faces (12b1, 12b2) of the handle that are orthogonal to a moving direction of the drawer (12, 12a), wherein the first counter face of the engagement portion is to face downstream one (12b1) of the pair of faces (12b1, 12b2) of the handle in the moving direction, wherein the second counter face of the engagement portion is to face upstream one (12b2) of the pair of faces (12b1, 12b2) of the handle in the moving direction, and wherein the engagement portion has an opening to which the handle is to be inserted, characterized in that the first counter face has a first protrusion protruding toward the second counter face, the second counter face has a second protrusion protruding toward the first counter face, and each of the first protrusion and the second protrusion is disposed at a position lower than the position of the handle when the operation assisting tool is attached to the handle.
Building panels provided with a locking system comprising a tongue at a second edge of a second panel, the tongue being configured to cooperate with a tongue groove at a first edge of a first panel for locking in a vertical direction, the tongue groove comprising an upper lip and a lower lip, the locking system further comprising one or more clips attached to the first edge and a downwardly open locking groove formed at the second edge, wherein each clip comprises an upwardly extending locking element, which is configured to cooperate with the locking groove for locking the first edge and the second edge in a horizontal direction, wherein: the clip comprises a clip body at a rear side of the first panel, said clip body being provided with an inner part, which extends inwardly from the first edge, and an outer part, which extends outwardly from said first edge, the inner part comprises a fixing element that cooperates with a downwardly open fixing groove, formed on the rear side of the first panel, for locking the clip to the first edge in a horizontal direction, the clip comprises a locking protrusion, which protrudes upwardly from the clip body, said locking protrusion being configured to lock the clip to the first edge in a vertical direction, the lower lip or the tongue comprises a recess, and the locking protrusion is in a locked position positioned in the recess, characterized in that said locking protrusion is spaced horizontally inwardly in the tongue groove beyond the outer tip of the tongue. the clip comprises a clip body at a rear side of the first panel, said clip body being provided with an inner part, which extends inwardly from the first edge, and an outer part, which extends outwardly from said first edge, the inner part comprises a fixing element that cooperates with a downwardly open fixing groove, formed on the rear side of the first panel, for locking the clip to the first edge in a horizontal direction, the clip comprises a locking protrusion, which protrudes upwardly from the clip body, said locking protrusion being configured to lock the clip to the first edge in a vertical direction, the lower lip or the tongue comprises a recess, and the locking protrusion is in a locked position positioned in the recess, characterized in that said locking protrusion is spaced horizontally inwardly in the tongue groove beyond the outer tip of the tongue.