A vehicle body frame structure of a straddle-type vehicle, the vehicle body frame structure comprising: a head pipe into which a steering shaft connected to a handle is inserted; and a pair of main frames extending rearward and outward in a vehicle width direction from the head pipe in such a manner that the main frames are spaced apart from each other in the vehicle width direction, wherein each of the main frames includes an upper frame extending rearward from an upper portion of the head pipe, a lower frame extending rearward from a lower portion of the head pipe, and coupling frames (18a-18e) coupling the upper frame to the lower frame, and wherein the end portion of the handle in a turn operation state tends to overlap with the main frame when viewed from a side, characterized in that between the upper frame and the lower frame, a retraction space which is located inward in the vehicle width direction relative to an end portion of the handle in the turn operation state is provided, and in that, at a location that is above at least the end portion of the handle in the turn operation state, the upper frame extends in a vehicle length direction in such a manner that the upper frame protrudes farther upward than a virtual flat plane extending through a connection portion of the upper frame and the head pipe and being perpendicular to a rotational axis of the steering shaft; and the upper frame extends rearward with from the head pipe at a location that is inward in the vehicle width direction relative to the lower frame and the coupling frames (18a-18e) are placed in such a manner that they do not overlap with the end portions of the handle in the turn operation state when viewed from the side. a head pipe into which a steering shaft connected to a handle is inserted; and a pair of main frames extending rearward and outward in a vehicle width direction from the head pipe in such a manner that the main frames are spaced apart from each other in the vehicle width direction, wherein each of the main frames includes an upper frame extending rearward from an upper portion of the head pipe, a lower frame extending rearward from a lower portion of the head pipe, and coupling frames (18a-18e) coupling the upper frame to the lower frame, and wherein the end portion of the handle in a turn operation state tends to overlap with the main frame when viewed from a side, characterized in that between the upper frame and the lower frame, a retraction space which is located inward in the vehicle width direction relative to an end portion of the handle in the turn operation state is provided, and in that, at a location that is above at least the end portion of the handle in the turn operation state, the upper frame extends in a vehicle length direction in such a manner that the upper frame protrudes farther upward than a virtual flat plane extending through a connection portion of the upper frame and the head pipe and being perpendicular to a rotational axis of the steering shaft; and the upper frame extends rearward with from the head pipe at a location that is inward in the vehicle width direction relative to the lower frame and the coupling frames (18a-18e) are placed in such a manner that they do not overlap with the end portions of the handle in the turn operation state when viewed from the side.