An oral sustained-release composition for an insoluble drug, wherein the oral sustained-release composition comprises a sustained-release granule part and a gel skeleton part, the sustained-release granule part comprises the insoluble drug, an enteric material and a strong liquid sorbent; the gel skeleton part comprises a hydrophilic gel skeleton material; and the sustained-release granules are obtained by preparing the insoluble drug and a liquid substance containing the enteric material into a suspension and then spraying the suspension onto the strong liquid sorbent, wherein the insoluble drug in the sustained-release granules accounts for 2%-15% of a weight of the sustained-release granules, a weight ratio of the insoluble drug to the enteric material is 1: 2 to 1: 4, and the strong liquid sorbent accounts for 35%-75% of the weight of the sustained-release granules; the sustained-release granules account for 40%-70% of a weight of the oral sustained-release composition; and a dose of the hydrophilic gel skeleton material account for 20%-50% of the weight of the oral sustained-release composition; wherein the liquid substance containing the enteric material is in an aqueous dispersion form or an organic solvent solution form of the enteric material, wherein the aqueous dispersion form of the enteric material is obtained by adding water and/or water containing an alkaline substance to the enteric material, and the organic solvent solution of the enteric material is obtained by dissolving the enteric material with an organic solvent; wherein a solid content of the drug-containing suspension is 10-35%; and wherein the strong liquid sorbent is any one of the following group: microcrystalline cellulose, croscarmellose sodium, croscarmellose, polyvinylpolypyrrolidone, sodium carboxymethyl starch, low substituted hydroxypropyl cellulose, starch and pregelatinized starch wherein the enteric material is a polymer material soluble in a pH range of 6-8, and the drug coated by the enteric material is capable of being completely released in a position of colon. wherein the enteric material is any one of a copolymer of methacrylic acid and methyl methacrylate, and a copolymer of methacrylic acid, methyl acrylate, and methyl methacrylate. wherein the liquid substance containing the enteric material is in an aqueous dispersion form or an organic solvent solution form of the enteric material, wherein the aqueous dispersion form of the enteric material is obtained by adding water and/or water containing an alkaline substance to the enteric material, and the organic solvent solution of the enteric material is obtained by dissolving the enteric material with an organic solvent; wherein a solid content of the drug-containing suspension is 10-35%; and wherein the strong liquid sorbent is any one of the following group: microcrystalline cellulose, croscarmellose sodium, croscarmellose, polyvinylpolypyrrolidone, sodium carboxymethyl starch, low substituted hydroxypropyl cellulose, starch and pregelatinized starch wherein the enteric material is a polymer material soluble in a pH range of 6-8, and the drug coated by the enteric material is capable of being completely released in a position of colon. wherein the enteric material is any one of a copolymer of methacrylic acid and methyl methacrylate, and a copolymer of methacrylic acid, methyl acrylate, and methyl methacrylate.