Detection system for detecting at least one extracellular vesicle in a microfluid, comprising: a broadband light source, generating at least one incident beam of light in the near infrared region; collimating optics; focusing optics; a coupler; a spectrophotometer; and an active sensing element comprising: a substrate; a metal layer with a thickness of 15-50 nanometers, deposited on said substrate; and a dielectric waveguide layer, deposited on said thin metal layer, wherein said thin metal layer and said dielectric waveguide layer comprise a waveguide; wherein said collimating optics collimates said beam of light which is coupled to said substrate via said coupler; wherein said focusing optics receives at least one reflection of said at least one incident beam of light from said substrate via said coupler and provides said at least one reflection to said spectrophotometer; wherein said active sensing element causes surface plasmon waves in said microfluid when said microfluid is injected into said microfluid apparatus; and wherein said spectrophotometer detects resonance wavelength shifts in said at least one reflection according to said surface plasmon waves thereby detecting the presence of said at least one extracellular vesicle in said microfluid; the detection system being characterized in that it further comprises a microfluidic apparatus, comprising an inlet and an outlet, wherein the active sensing element is positioned inside said microfluid apparatus, and in that said dielectric waveguide layer is a polymeric dielectric waveguide layer with a thickness between 500-1500 nanometers. a broadband light source, generating at least one incident beam of light in the near infrared region; collimating optics; focusing optics; a coupler; a spectrophotometer; and an active sensing element comprising: a substrate; a metal layer with a thickness of 15-50 nanometers, deposited on said substrate; and a dielectric waveguide layer, deposited on said thin metal layer, wherein said thin metal layer and said dielectric waveguide layer comprise a waveguide; wherein said collimating optics collimates said beam of light which is coupled to said substrate via said coupler; wherein said focusing optics receives at least one reflection of said at least one incident beam of light from said substrate via said coupler and provides said at least one reflection to said spectrophotometer; wherein said active sensing element causes surface plasmon waves in said microfluid when said microfluid is injected into said microfluid apparatus; and wherein said spectrophotometer detects resonance wavelength shifts in said at least one reflection according to said surface plasmon waves thereby detecting the presence of said at least one extracellular vesicle in said microfluid; the detection system being characterized in that it further comprises a microfluidic apparatus, comprising an inlet and an outlet, wherein the active sensing element is positioned inside said microfluid apparatus, and in that said dielectric waveguide layer is a polymeric dielectric waveguide layer with a thickness between 500-1500 nanometers. a substrate; a metal layer with a thickness of 15-50 nanometers, deposited on said substrate; and a dielectric waveguide layer, deposited on said thin metal layer, wherein said thin metal layer and said dielectric waveguide layer comprise a waveguide; wherein said collimating optics collimates said beam of light which is coupled to said substrate via said coupler; wherein said focusing optics receives at least one reflection of said at least one incident beam of light from said substrate via said coupler and provides said at least one reflection to said spectrophotometer; wherein said active sensing element causes surface plasmon waves in said microfluid when said microfluid is injected into said microfluid apparatus; and wherein said spectrophotometer detects resonance wavelength shifts in said at least one reflection according to said surface plasmon waves thereby detecting the presence of said at least one extracellular vesicle in said microfluid; the detection system being characterized in that it further comprises a microfluidic apparatus, comprising an inlet and an outlet, wherein the active sensing element is positioned inside said microfluid apparatus, and in that said dielectric waveguide layer is a polymeric dielectric waveguide layer with a thickness between 500-1500 nanometers.