A process for preparing a peptide tertiary amide of formula or its enantiomer with the opposite stereochemistry at Cα: wherein R 1 is selected from optionally substituted C 1 -C 10 alkyl, optionally substituted aryl, optionally substituted alkaryl, optionally substituted alkoxyl, optionally substituted heteroaryl, optionally substituted arylalkoxyl, optionally substituted acyl, OH, OR' NH 2, NHR', NR' 2, SH, SR', C R', and an amino acid side chain; R 2 is selected from optionally substituted C 2 -C 10 alkyl, optionally substituted aryl, optionally substituted alkaryl, optionally substituted alkoxyl, optionally substituted heteroaryl, optionally arylalkoxyl, optionally substituted acyl, OH, OR', NH 2, NHR', NR' 2, SH, SR', C R', and an amino acid side chain; wherein R' is selected from optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 alkenyl, optionally substituted C 1 -C 10 alkynyl, optionally substituted aryl, optionally substituted alkaryl, and optionally substituted acyl; comprising: oxidizing a primary amine of an amino acid of formula with an oxidizing agent followed by treatment with a nucleophilic bromide source to give an optically pure 2-bromo acid of formula: wherein the synthesis comprises a solid or semi-solid phase synthetic step; wherein the solid or semi-solid phase synthetic step comprises bonding the 2-bromo acid of formula to the solid-phase bead using a coupling agent in an appropriate solvent to give a compound of formula: wherein the compound of formula is reacted with an amine of formula: NH 2 -R 2 to give a compound of formula: and wherein the compound of formula is further reacted with additional 2-bromo acid of formula followed by amine of formula to obtain oligomers of the compound of formula. wherein R 1 is selected from optionally substituted C 1 -C 10 alkyl, optionally substituted aryl, optionally substituted alkaryl, optionally substituted alkoxyl, optionally substituted heteroaryl, optionally substituted arylalkoxyl, optionally substituted acyl, OH, OR' NH 2, NHR', NR' 2, SH, SR', C R', and an amino acid side chain; R 2 is selected from optionally substituted C 2 -C 10 alkyl, optionally substituted aryl, optionally substituted alkaryl, optionally substituted alkoxyl, optionally substituted heteroaryl, optionally arylalkoxyl, optionally substituted acyl, OH, OR', NH 2, NHR', NR' 2, SH, SR', C R', and an amino acid side chain; wherein R' is selected from optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 alkenyl, optionally substituted C 1 -C 10 alkynyl, optionally substituted aryl, optionally substituted alkaryl, and optionally substituted acyl; comprising: oxidizing a primary amine of an amino acid of formula with an oxidizing agent followed by treatment with a nucleophilic bromide source to give an optically pure 2-bromo acid of formula: wherein the synthesis comprises a solid or semi-solid phase synthetic step; wherein the solid or semi-solid phase synthetic step comprises bonding the 2-bromo acid of formula to the solid-phase bead using a coupling agent in an appropriate solvent to give a compound of formula: wherein the compound of formula is reacted with an amine of formula: NH 2 -R 2 to give a compound of formula: and wherein the compound of formula is further reacted with additional 2-bromo acid of formula followed by amine of formula to obtain oligomers of the compound of formula. oxidizing a primary amine of an amino acid of formula with an oxidizing agent followed by treatment with a nucleophilic bromide source to give an optically pure 2-bromo acid of formula: wherein the synthesis comprises a solid or semi-solid phase synthetic step; wherein the solid or semi-solid phase synthetic step comprises bonding the 2-bromo acid of formula to the solid-phase bead using a coupling agent in an appropriate solvent to give a compound of formula: wherein the compound of formula is reacted with an amine of formula: NH 2 -R 2 to give a compound of formula: and wherein the compound of formula is further reacted with additional 2-bromo acid of formula followed by amine of formula to obtain oligomers of the compound of formula.