System for exfoliating a layered material, comprising in combination: an exfoliation station operating on a volume of a dispersion of a layered precursor material, including a wet-jet milling device; and a collecting station (30, 40), arranged downstream of the exfoliation station, operating on a volume of a dispersion of at least partially exfoliated material, wherein the exfoliation station and the collecting station (30, 40) are connected to each other through a fluid communication path along which there are interposed flow regulating means, said flow regulating means being adapted to assume a first operating configuration in which the communication path between the exfoliation station and the collecting station (30, 40) is discontinued, whereby the exfoliation station is adapted to expose a volume of a dispersion of a layered precursor material to a predetermined number of wet-jet milling cycles, and the collecting station (30, 40) is adapted to extract an amount of exfoliated material from the volume of the dispersion previously exposed to milling and including material at least partially exfoliated; and a second operative configuration in which the communication path between the exfoliation station and the collecting station (30, 40) is continuous, whereby the exfoliation station is adapted to convey a volume of a dispersion previously exposed to milling and including a material at least partially exfoliated towards the collecting station (30, 40), and the exfoliation station is placed in connection with a supply chamber so as to be fed with a further volume of a dispersion of a layered precursor material. an exfoliation station operating on a volume of a dispersion of a layered precursor material, including a wet-jet milling device; and a collecting station (30, 40), arranged downstream of the exfoliation station, operating on a volume of a dispersion of at least partially exfoliated material, wherein the exfoliation station and the collecting station (30, 40) are connected to each other through a fluid communication path along which there are interposed flow regulating means, said flow regulating means being adapted to assume a first operating configuration in which the communication path between the exfoliation station and the collecting station (30, 40) is discontinued, whereby the exfoliation station is adapted to expose a volume of a dispersion of a layered precursor material to a predetermined number of wet-jet milling cycles, and the collecting station (30, 40) is adapted to extract an amount of exfoliated material from the volume of the dispersion previously exposed to milling and including material at least partially exfoliated; and a second operative configuration in which the communication path between the exfoliation station and the collecting station (30, 40) is continuous, whereby the exfoliation station is adapted to convey a volume of a dispersion previously exposed to milling and including a material at least partially exfoliated towards the collecting station (30, 40), and the exfoliation station is placed in connection with a supply chamber so as to be fed with a further volume of a dispersion of a layered precursor material.