A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, wherein the meanings are: X is S or O; D is N or -C =; R is H, (C 1 -C 6)-alkyl, (C 3 -C 8)-cycloalkyl; R1 is H, (C 1 -C 6)-alkyl, (C 3 -C 8)-cycloalkyl, (C 1 -C 6)-alkylen-(C 3 -C 8)-cycloalkyl; wherein alkyl is optionally substituted by one ore more F-atoms; R3 is H, methyl or ethyl; R2 is Hydrogen or (C 1 -C 6 -)-alkyl; E 1 is N or -C =; E 2 is N or -C =; E 3 is N or -C =; E 4 is N or -C =; wherein none or one of E 1, E 2, E 3 or E 4 is N; R4 is H or O-(C 1 -C 6)-alkyl; R5 is H F, Cl, CF 3, (C 1 -C 6)-alkyl, (C 1 -C 6)-cycloalkyl; R6 is H or -O-CH 2 -phenyl; R7 is H; G 1 is N or -C =; G 2 is N or -C =; G 3 is N or -C =; G 4 is N or -C =; wherein none or one of G 1, G 2, G 3 or G 4 is N; or G 3 and G 4 are -C = and -C =, wherein R10 and R11 form a 4 to 7 membered saturated carbocycle- or heterocycle with one or two oxygen atoms; which is optionally mono- or disubstituted by (C 1 -C 3)-alkyl; R8 is H, F, Cl, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl, CF 3 or OCF 3; R9 is H, F, Cl, OH, O-(C 1 -C 6)-alkyl, CH 2 OH, CO-NH 2, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl, CF 3 or OCF 3; R10 is H, F, Cl, OH, (C 1 -C 6)-alkyl, CH 2 OH, CO-O-(C 1 -C 6)-alkyl, SO 2 -(C 1 -C 6)-alkyl, CN, O-(C 1 -C 6)-alkyl, CF 3, CH 2 -CN, C(CH 3) 2)-CN, (C 1 -C 6)-alkyl-OH, -O-(C 1 -C 6)-alkyl-OH, -O-CH 2 -CO-(C 1 -C 6)-alkyl or OCF 3; R11 is H, F, Cl, OH, O-(C 1 -C 6)-alkyl, CH 2 OH, CO-(C 1 -C 6)-methyl, CO-N(R20R21), CO-O-(C 1 -C 6)-alkyl, CN, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl or OCF 3; wherein R20 and R21 are independently from each other H or (C 1 -C 3)-alkyl or form together with the nitrogen to which they are attached a 5 or 6 membered saturated ring. X is S or O; D is N or -C =; R is H, (C 1 -C 6)-alkyl, (C 3 -C 8)-cycloalkyl; R1 is H, (C 1 -C 6)-alkyl, (C 3 -C 8)-cycloalkyl, (C 1 -C 6)-alkylen-(C 3 -C 8)-cycloalkyl; wherein alkyl is optionally substituted by one ore more F-atoms; R3 is H, methyl or ethyl; R2 is Hydrogen or (C 1 -C 6 -)-alkyl; E 1 is N or -C =; E 2 is N or -C =; E 3 is N or -C =; E 4 is N or -C =; wherein none or one of E 1, E 2, E 3 or E 4 is N; R4 is H or O-(C 1 -C 6)-alkyl; R5 is H F, Cl, CF 3, (C 1 -C 6)-alkyl, (C 1 -C 6)-cycloalkyl; R6 is H or -O-CH 2 -phenyl; R7 is H; G 1 is N or -C =; G 2 is N or -C =; G 3 is N or -C =; G 4 is N or -C =; wherein none or one of G 1, G 2, G 3 or G 4 is N; or G 3 and G 4 are -C = and -C =, wherein R10 and R11 form a 4 to 7 membered saturated carbocycle- or heterocycle with one or two oxygen atoms; which is optionally mono- or disubstituted by (C 1 -C 3)-alkyl; R8 is H, F, Cl, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl, CF 3 or OCF 3; R9 is H, F, Cl, OH, O-(C 1 -C 6)-alkyl, CH 2 OH, CO-NH 2, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl, CF 3 or OCF 3; R10 is H, F, Cl, OH, (C 1 -C 6)-alkyl, CH 2 OH, CO-O-(C 1 -C 6)-alkyl, SO 2 -(C 1 -C 6)-alkyl, CN, O-(C 1 -C 6)-alkyl, CF 3, CH 2 -CN, C(CH 3) 2)-CN, (C 1 -C 6)-alkyl-OH, -O-(C 1 -C 6)-alkyl-OH, -O-CH 2 -CO-(C 1 -C 6)-alkyl or OCF 3; R11 is H, F, Cl, OH, O-(C 1 -C 6)-alkyl, CH 2 OH, CO-(C 1 -C 6)-methyl, CO-N(R20R21), CO-O-(C 1 -C 6)-alkyl, CN, (C 1 -C 6)-alkyl, O-(C 1 -C 6)-alkyl or OCF 3; wherein R20 and R21 are independently from each other H or (C 1 -C 3)-alkyl or form together with the nitrogen to which they are attached a 5 or 6 membered saturated ring.