A compound of the formula: or the reduced form thereof; wherein: X and Y are C; or X is N, Y is C, and R 2 is not present; or X is C, Y is N, and R 5 is not present; Z is N or N-oxide, wherein when Z is N-oxide then X and Y are C; R 1 is -C(R 11)(R 12)-; R 2, R 3, R 4, and R 5 are each independently selected from the group consisting of hydrogen, C 1 -C 6 haloalkyl, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, C 1 -C 6 alkoxy, -C OH, -C O(phenyl), -C NR 13 R 14, -OH, and C 1 -C 6 haloalkoxy; R 6 is C 1 -C 6 alkyl, H, or OH; where the C 1 -C 6 alkyl is optionally substituted with a 3-7 membered heterocyclic group which is optionally substituted with one C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 7, R 8, R 9, and R 10 are each independently selected from the group consisting of: hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, hydroxy, C 1 -C 6 alkoxy, -NHSO 2 CH 3, and 5-6 membered heteroaryl where the 5-6 membered heteroaryl is optionally substituted with one C 1 -C 6 alkyl; R 11 and R 12 are independently selected from the group consisting of hydrogen, methyl, and methoxy; with the proviso that R 11 and R 12 are not both methoxy; and R 13 and R 14 are each independently H or C 1 -C 6 alkyl; or wherein R 13 and R 14 together with the nitrogen atom to which they are attached form a 4-6 membered saturated heterocyclic ring in which one of the carbons is optionally replaced by an additional N, and wherein the 4-6 membered saturated heterocyclic ring is optionally substituted with one or more substituents independently selected from the group consisting of halo and C 1 -C 6 alkyl; or any salt(s), stereoisomer, mixture of stereoisomers, isotopologue(s), solvate(s), and/or hydrate(s) thereof. X and Y are C; or X is N, Y is C, and R 2 is not present; or X is C, Y is N, and R 5 is not present; Z is N or N-oxide, wherein when Z is N-oxide then X and Y are C; R 1 is -C(R 11)(R 12)-; R 2, R 3, R 4, and R 5 are each independently selected from the group consisting of hydrogen, C 1 -C 6 haloalkyl, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cyano, C 1 -C 6 alkoxy, -C OH, -C O(phenyl), -C NR 13 R 14, -OH, and C 1 -C 6 haloalkoxy; R 6 is C 1 -C 6 alkyl, H, or OH; where the C 1 -C 6 alkyl is optionally substituted with a 3-7 membered heterocyclic group which is optionally substituted with one C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 7, R 8, R 9, and R 10 are each independently selected from the group consisting of: hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, hydroxy, C 1 -C 6 alkoxy, -NHSO 2 CH 3, and 5-6 membered heteroaryl where the 5-6 membered heteroaryl is optionally substituted with one C 1 -C 6 alkyl; R 11 and R 12 are independently selected from the group consisting of hydrogen, methyl, and methoxy; with the proviso that R 11 and R 12 are not both methoxy; and R 13 and R 14 are each independently H or C 1 -C 6 alkyl; or wherein R 13 and R 14 together with the nitrogen atom to which they are attached form a 4-6 membered saturated heterocyclic ring in which one of the carbons is optionally replaced by an additional N, and wherein the 4-6 membered saturated heterocyclic ring is optionally substituted with one or more substituents independently selected from the group consisting of halo and C 1 -C 6 alkyl; or any salt(s), stereoisomer, mixture of stereoisomers, isotopologue(s), solvate(s), and/or hydrate(s) thereof.