A combination comprising: a composition in form of eye wash comprising: (i) a mixture comprising, or alternatively, consisting of: (i-a) an alginic acid, or a salt thereof, (i-b) a hyaluronic acid, or a salt thereof, and, optionally, (ii) at least one technological additive and/or at least one pharmaceutical or food grade excipient; and a composition in form of tablet comprising: (iii) a mixture comprising, or alternatively, consisting of: (iii-a) an alginic acid or a salt thereof of an alkaline metal or of an alkaline earth metal; (iii-b) a bicarbonate salt of an alkaline metal or alkaline earth and/or a carbonate salt of an alkaline metal or alkaline earth; (iii-c) a simethicone and/or dimethicone; and, optionally, (iv) at least one technological additive and/or at least one pharmaceutical or food grade excipient; said combination being for use in a method for the preventive or curative treatment of symptoms or diseases of the eyeball and periocular area, wherein said symptoms or diseases relate to, or derive from, extraoesophageal reflux or laryngopharyngeal reflux or from the backflow of the gastric content or of the acid gastric vapours from the stomach into at least one extraoesophageal area. a composition in form of eye wash comprising: (i) a mixture comprising, or alternatively, consisting of: (i-a) an alginic acid, or a salt thereof, (i-b) a hyaluronic acid, or a salt thereof, and, optionally, (ii) at least one technological additive and/or at least one pharmaceutical or food grade excipient; and (i) a mixture comprising, or alternatively, consisting of: (i-a) an alginic acid, or a salt thereof, (i-b) a hyaluronic acid, or a salt thereof, and, optionally, (i-a) an alginic acid, or a salt thereof, (i-b) a hyaluronic acid, or a salt thereof, and, optionally, (ii) at least one technological additive and/or at least one pharmaceutical or food grade excipient; and a composition in form of tablet comprising: (iii) a mixture comprising, or alternatively, consisting of: (iii-a) an alginic acid or a salt thereof of an alkaline metal or of an alkaline earth metal; (iii-b) a bicarbonate salt of an alkaline metal or alkaline earth and/or a carbonate salt of an alkaline metal or alkaline earth; (iii-c) a simethicone and/or dimethicone; and, optionally, (iv) at least one technological additive and/or at least one pharmaceutical or food grade excipient; said combination being for use in a method for the preventive or curative treatment of symptoms or diseases of the eyeball and periocular area, wherein said symptoms or diseases relate to, or derive from, extraoesophageal reflux or laryngopharyngeal reflux or from the backflow of the gastric content or of the acid gastric vapours from the stomach into at least one extraoesophageal area. (iii) a mixture comprising, or alternatively, consisting of: (iii-a) an alginic acid or a salt thereof of an alkaline metal or of an alkaline earth metal; (iii-b) a bicarbonate salt of an alkaline metal or alkaline earth and/or a carbonate salt of an alkaline metal or alkaline earth; (iii-c) a simethicone and/or dimethicone; and, optionally, (iii-a) an alginic acid or a salt thereof of an alkaline metal or of an alkaline earth metal; (iii-b) a bicarbonate salt of an alkaline metal or alkaline earth and/or a carbonate salt of an alkaline metal or alkaline earth; (iii-c) a simethicone and/or dimethicone; and, optionally, (iv) at least one technological additive and/or at least one pharmaceutical or food grade excipient; said combination being for use in a method for the preventive or curative treatment of symptoms or diseases of the eyeball and periocular area, wherein said symptoms or diseases relate to, or derive from, extraoesophageal reflux or laryngopharyngeal reflux or from the backflow of the gastric content or of the acid gastric vapours from the stomach into at least one extraoesophageal area.