mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula wherein A is NH, O, S, C=O, NR 3 or CR 4 R 5; Cy is an optionally substituted arylene, heteroarylene, cycloalkylene, heterocycloalkylene, alkylcycloalkylene, heteroalkylcycloalkylene, aralkylene or heteroaralkylene group; R 1 is an optionally substituted alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 2 is a hydrogen atom, a halogen atom, NO 2 N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 3 is an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 4 is a hydrogen atom, NO 2, N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; and R 5 is a hydrogen atom, NO 2, N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; or a pharmaceutically acceptable salt, ester, solvate or hydrate or a pharmaceutically acceptable formulation thereof, wherein the following compounds are excluded: A is NH, O, S, C=O, NR 3 or CR 4 R 5; Cy is an optionally substituted arylene, heteroarylene, cycloalkylene, heterocycloalkylene, alkylcycloalkylene, heteroalkylcycloalkylene, aralkylene or heteroaralkylene group; R 1 is an optionally substituted alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 2 is a hydrogen atom, a halogen atom, NO 2 N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 3 is an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; R 4 is a hydrogen atom, NO 2, N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; and R 5 is a hydrogen atom, NO 2, N 3, OH, SH, NH 2 or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl group; or a pharmaceutically acceptable salt, ester, solvate or hydrate or a pharmaceutically acceptable formulation thereof, wherein the following compounds are excluded:
A method for interfacing an input control device (102;C1,C2,C3,C4;402;602;1270;1314;1403) with a computer program executing at a base computing device, the method comprising: sending a command from the base computing device to the input control device; generating (1626, 1632) a visual cue at a spherical section of the input control device in response to the command sent from the base computing device, the visual cue providing at least one of user feedback and input for the computer program; determining whether the visual cue provides input for the computer program; and when the visual cue provides input for the computer program, the method comprises: capturing an image of the input control device at the base computing device; processing the visual cue at the base computing device based on the captured image of the input control device; and updating a state of an object being processed by the computer program in response to the input for the computer program, the updating used to drive interactivity with the computer program via the input control device. sending a command from the base computing device to the input control device; generating (1626, 1632) a visual cue at a spherical section of the input control device in response to the command sent from the base computing device, the visual cue providing at least one of user feedback and input for the computer program; determining whether the visual cue provides input for the computer program; and when the visual cue provides input for the computer program, the method comprises: capturing an image of the input control device at the base computing device; processing the visual cue at the base computing device based on the captured image of the input control device; and updating a state of an object being processed by the computer program in response to the input for the computer program, the updating used to drive interactivity with the computer program via the input control device. capturing an image of the input control device at the base computing device; processing the visual cue at the base computing device based on the captured image of the input control device; and updating a state of an object being processed by the computer program in response to the input for the computer program, the updating used to drive interactivity with the computer program via the input control device.
Use of a compound that activates an AMPA/kainate type receptor to stimulate glucagon release in the manufacture of a medicament to treat hypoglycemia.
A tissue therapy device comprising: a sealant layer, said sealant layer configured to create a sealed enclosure around an area of tissue requiring therapy; and a suction apparatus, said suction apparatus in fluid communication through the sealant layer with said enclosure, wherein said suction apparatus is configured to self-create a reduced pressure level within said enclosure; wherein said sealant layer and said suction apparatus are configured to create a closed reduced pressure system; and wherein the suction apparatus comprises a suction chamber, a reciprocating mechanism to alter a volume of the suction chamber which is in fluid communication with the enclosure, an actuator, a one-way flow valve adapted and configured to prevent fluid from returning to the area of tissue requiring therapy, and a helical threaded interface between the actuator and the suction chamber. a sealant layer, said sealant layer configured to create a sealed enclosure around an area of tissue requiring therapy; and a suction apparatus, said suction apparatus in fluid communication through the sealant layer with said enclosure, wherein said suction apparatus is configured to self-create a reduced pressure level within said enclosure; wherein said sealant layer and said suction apparatus are configured to create a closed reduced pressure system; and wherein the suction apparatus comprises a suction chamber, a reciprocating mechanism to alter a volume of the suction chamber which is in fluid communication with the enclosure, an actuator, a one-way flow valve adapted and configured to prevent fluid from returning to the area of tissue requiring therapy, and a helical threaded interface between the actuator and the suction chamber.
A level sensor for determining the presence or absence of a liquid in contact with the sensor with a mount for holding said sensor, comprising: an elongate probe; a transducer operably connected to the probe and configured to produce compressional waves in the probe; and circuitry for detecting acoustic energy emitted into the liquid, when liquid is in contact with the probe, a base having an inverted cup-shape that defines a well; at least one contact; and a cartridge configured to retain the probe therein, and being disposed in the base, characterized in that the transducer is operably connected to the contact which is positioned at the end of the well, and the cartridge is resiliently secured in the base, a seal is disposed to isolate the probe from the cartridge, the base having channels extending upwardly from the lower edge to form flexible fingers, the fingers having detents at about the end of each finger, the cartridge including a circumferential recess for engaging with the detents of the flexible fingers in a snap fit configuration. an elongate probe; a transducer operably connected to the probe and configured to produce compressional waves in the probe; and circuitry for detecting acoustic energy emitted into the liquid, when liquid is in contact with the probe, a base having an inverted cup-shape that defines a well; at least one contact; and a cartridge configured to retain the probe therein, and being disposed in the base, characterized in that the transducer is operably connected to the contact which is positioned at the end of the well, and the cartridge is resiliently secured in the base, a seal is disposed to isolate the probe from the cartridge, the base having channels extending upwardly from the lower edge to form flexible fingers, the fingers having detents at about the end of each finger, the cartridge including a circumferential recess for engaging with the detents of the flexible fingers in a snap fit configuration.
An industrial robot comprising a robot arm having a plurality of links connected by joints, one of said links being formed as a swing and another of said links being formed as an arm cantilever pivotally supported on one side of said swing by means of one of said joints about an axis of rotation and carrying at least two more of said links forming hand links of said robot arm, further comprising an arm cantilever drive with a motor shaft arranged on the arm cantilever and adapted to pivot the arm cantilever with respect to the swing, a first hand link drive with a motor shaft arranged on the arm cantilever and adapted to move one of the hand links (21, 22, 23) with respect to the arm cantilever, preferably a second hand link drive arranged on the arm cantilever with a motor shaft and adapted to move another one of the hand links (21, 22, 23) with respect to the arm cantilever and/or with respect to the one hand link (21, 22), wherein the motor shaft of the arm cantilever drive is arranged on the arm cantilever aligned at a distance offset parallel to the axis of rotation, and wherein the motor shaft of the first hand link drive is arranged on the arm cantilever aligned perpendicular to the axis of rotation at a distance from the axis of rotation, characterized in that the first hand link drive and preferably the second hand link drive with their respective motor shafts (14a, 15a) are arranged on the arm cantilever at a distance from the axis of rotation, which is oriented opposite to the direction with which the motor shaft of the arm cantilever drive is arranged on the arm cantilever aligned at a distance offset parallel to the axis of rotation. further comprising an arm cantilever drive with a motor shaft arranged on the arm cantilever and adapted to pivot the arm cantilever with respect to the swing, a first hand link drive with a motor shaft arranged on the arm cantilever and adapted to move one of the hand links (21, 22, 23) with respect to the arm cantilever, preferably a second hand link drive arranged on the arm cantilever with a motor shaft and adapted to move another one of the hand links (21, 22, 23) with respect to the arm cantilever and/or with respect to the one hand link (21, 22), wherein the motor shaft of the arm cantilever drive is arranged on the arm cantilever aligned at a distance offset parallel to the axis of rotation, and wherein the motor shaft of the first hand link drive is arranged on the arm cantilever aligned perpendicular to the axis of rotation at a distance from the axis of rotation, characterized in that the first hand link drive and preferably the second hand link drive with their respective motor shafts (14a, 15a) are arranged on the arm cantilever at a distance from the axis of rotation, which is oriented opposite to the direction with which the motor shaft of the arm cantilever drive is arranged on the arm cantilever aligned at a distance offset parallel to the axis of rotation.
A branched carboxylic acid functional polyester resin P1, having: a. a T g of at least 40°C as measured by Differential Scanning Calorimetry at a heating rate of 5°C/min; and b. an acid value of at least 19 and of at most 35 mg KOH/g P1; and c. a hydroxyl value of at most 7 mg KOH/g P1; and d. a functionality of at least 2.1 and of at most 3; and said polyester resin P1 being the reaction product of at least the following monomers: i) neopentyl glycol in an amount of at least 25 and of at most 50 mol%; and ii) ethylene glycol in an amount of at least 2.5 and of at most 20 mol%; and iii) a C 6 diol in an amount of at least 1.1 and of at most 4.9 mol%; and iv) isophthalic acid in an amount of at least 0 and of a most 6.5 mol%; and v) terephthalic acid in an amount of at least 39 and of at most 48 mol%; and vi) adipic acid in an amount of at least 1 and of at most 10 mol%; and vii) an at least trifunctional monomer in an amount of at least 0.001 and of at most 3 mol%; and wherein the mol% is based on the polyester resin P1 and wherein the total amount of monomers used for the preparation of the polyester resin P1 is 100 mol%. a. a T g of at least 40°C as measured by Differential Scanning Calorimetry at a heating rate of 5°C/min; and b. an acid value of at least 19 and of at most 35 mg KOH/g P1; and c. a hydroxyl value of at most 7 mg KOH/g P1; and d. a functionality of at least 2.1 and of at most 3; and said polyester resin P1 being the reaction product of at least the following monomers: i) neopentyl glycol in an amount of at least 25 and of at most 50 mol%; and ii) ethylene glycol in an amount of at least 2.5 and of at most 20 mol%; and iii) a C 6 diol in an amount of at least 1.1 and of at most 4.9 mol%; and iv) isophthalic acid in an amount of at least 0 and of a most 6.5 mol%; and v) terephthalic acid in an amount of at least 39 and of at most 48 mol%; and vi) adipic acid in an amount of at least 1 and of at most 10 mol%; and vii) an at least trifunctional monomer in an amount of at least 0.001 and of at most 3 mol%; and wherein the mol% is based on the polyester resin P1 and wherein the total amount of monomers used for the preparation of the polyester resin P1 is 100 mol%. i) neopentyl glycol in an amount of at least 25 and of at most 50 mol%; and ii) ethylene glycol in an amount of at least 2.5 and of at most 20 mol%; and iii) a C 6 diol in an amount of at least 1.1 and of at most 4.9 mol%; and iv) isophthalic acid in an amount of at least 0 and of a most 6.5 mol%; and v) terephthalic acid in an amount of at least 39 and of at most 48 mol%; and vi) adipic acid in an amount of at least 1 and of at most 10 mol%; and vii) an at least trifunctional monomer in an amount of at least 0.001 and of at most 3 mol%;
A turbine engine comprising: a compressor section; a combustor section in fluid communication with the compressor section; a turbine section in fluid communication with the combustor section; a mixing chamber defined by an inner diffuser case wall, an outer diffuser case wall, and a mixing chamber wall, wherein the mixing chamber is located between the compressor section and the combustor section and wherein the mixing chamber is radially outward of a primary fluid flow path connecting the compressor section, the combustor section, and the turbine section; and wherein said mixing chamber wall isolates said mixing chamber from a diffuser chamber, and wherein said mixing chamber wall includes a seal having local penetrations such that diffuser air can travel from said diffuser into said mixing chamber. a compressor section; a combustor section in fluid communication with the compressor section; a turbine section in fluid communication with the combustor section; a mixing chamber defined by an inner diffuser case wall, an outer diffuser case wall, and a mixing chamber wall, wherein the mixing chamber is located between the compressor section and the combustor section and wherein the mixing chamber is radially outward of a primary fluid flow path connecting the compressor section, the combustor section, and the turbine section; and wherein said mixing chamber wall isolates said mixing chamber from a diffuser chamber, and wherein said mixing chamber wall includes a seal having local penetrations such that diffuser air can travel from said diffuser into said mixing chamber.
A method performed by a Base Station, BS, in a Time Division Duplex, TDD, system, wherein there is at least one TDD uplink, UL,/downlink, DL, configuration for subframes in the TDD system, and the at least one UL/DL configuration comprises at least one special subframe and at least one UL subframe, wherein the method is characterised by: sending to a user equipment, UE, a message; in response to the UE determining that the message includes a first indication indicating that a special subframe is to be applied in TTI bundling, receiving on a Physical Uplink Shared Channel, PUSCH, TTI bundling packets from the UE using an Uplink Pilot Time Slot, UpPTS, of the at least one special subframe, wherein the TTI bundling packets are received from the UE using the special subframe in a respective TDD UL/DL configuration whose total number of uplink subframes and special subframes per radio frame is the number of TTIs of a bundle being 4; and in response to the UE determining that the message does not include the first indication, receiving TTI bundling packets from the UE in TDD UL/DL configuration 0, 1, or 6 on UL subframes only. sending to a user equipment, UE, a message; in response to the UE determining that the message includes a first indication indicating that a special subframe is to be applied in TTI bundling, receiving on a Physical Uplink Shared Channel, PUSCH, TTI bundling packets from the UE using an Uplink Pilot Time Slot, UpPTS, of the at least one special subframe, wherein the TTI bundling packets are received from the UE using the special subframe in a respective TDD UL/DL configuration whose total number of uplink subframes and special subframes per radio frame is the number of TTIs of a bundle being 4; and in response to the UE determining that the message does not include the first indication, receiving TTI bundling packets from the UE in TDD UL/DL configuration 0, 1, or 6 on UL subframes only.
A flexible sheath for use in endoscopic procedures, wherein the flexible sheath comprises: an elongate tubular body having an elongate tubular body proximal end and an elongate tubular body distal end; a braided body portion extending from the elongate tubular body distal end to the elongate tubular body proximal end, a marker region positioned at the elongate tubular body distal end, wherein the composition of the braided body portion is a heat-resistant synthetic fiber, wherein the diameter of the flexible sheath is less than 5 mm, and wherein the composition of the marker region is a high temperature resistant plastic substrate with a high density ceramic coating. an elongate tubular body having an elongate tubular body proximal end and an elongate tubular body distal end; a braided body portion extending from the elongate tubular body distal end to the elongate tubular body proximal end, a marker region positioned at the elongate tubular body distal end, wherein the composition of the braided body portion is a heat-resistant synthetic fiber, wherein the diameter of the flexible sheath is less than 5 mm, and wherein the composition of the marker region is a high temperature resistant plastic substrate with a high density ceramic coating.
A compound for use in enhancing therapeutic or prophylactic effect of administering (a) renin-angiotensin system inhibitor(s) on (a) renal disease(s), wherein said renin-angiotensin system inhibitor is selected from the group consisting of enalapril maleate, lisinopril, perindopril erbumine, losartan, candesartan cilexetil, telmisartan, and candesartan, wherein said compound comprises as an effective ingredient a prostaglandin I derivative, being beraprost or pharmaceutically acceptable salt thereof, represented by the Formula: [wherein R 1 is COOR 2, wherein R 2 is hydrogen or a pharmaceutically acceptable cation, A is -(CH 2) m -, wherein m is 3, Y is hydrogen, B is -X-C(R 11)(R 12)OR 13, wherein R 11 and R 13 are hydrogen, X is -CH=CH-, R 12 is -C u H 2u -C≡C-R 17, wherein u is 3, C u H 2u is branched alkylene, and R 17 is methyl, E is -OH, wherein said formula includes d-isomers, 1-isomers and racemic compounds]. [wherein R 1 is COOR 2, wherein R 2 is hydrogen or a pharmaceutically acceptable cation, A is -(CH 2) m -, wherein m is 3, Y is hydrogen, B is -X-C(R 11)(R 12)OR 13, wherein R 11 and R 13 are hydrogen, X is -CH=CH-, R 12 is -C u H 2u -C≡C-R 17, wherein u is 3, C u H 2u is branched alkylene, and R 17 is methyl, E is -OH,
A security plug for a fastener having a longitudinally extending female socket adapted to receive a first tool, the plug adapted to be inserted into the female socket to prevent the first tool engaging in the female socket, the plug comprising: - an outer surface portion complementary to the female socket; - at least one retaining member for retaining the plug in the female socket, and - at least one removal portion comprising at least one first engagement surface adapted to be engaged by a second tool having at least one second engagement surface complementary to the at least one first engagement surface, whereby mechanical engagement of the at least one first and second engagement surfaces (70, 104) provides mechanical engagement between the second tool and the plug to allow force applied longitudinally by the second tool on the plug to withdraw the plug from the female socket against the action of the at least one retaining member, wherein at least one first engagement surface has a Morse taper or a Morse like taper. - an outer surface portion complementary to the female socket; - at least one retaining member for retaining the plug in the female socket, and - at least one removal portion comprising at least one first engagement surface adapted to be engaged by a second tool having at least one second engagement surface complementary to the at least one first engagement surface, whereby mechanical engagement of the at least one first and second engagement surfaces (70, 104) provides mechanical engagement between the second tool and the plug to allow force applied longitudinally by the second tool on the plug to withdraw the plug from the female socket against the action of the at least one retaining member,