mhurhangee/ep-ind-claims huggingface dataset:
A compound having the formula I: or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, -OH, -OC 1-6 alkyl, or halogen; R 8 is hydrogen, deuterium, or -C 1-6 alkyl; R 11 and R 12 are independently hydrogen, -C 1-6 alkyl, -OH, -OC 1-6 alkyl, or halogen; R 13 and R 14 are independently -C 1-6 alkyl, -(CH 2) 1-2 OH, or -OC 1-6 alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or -C 1-6 alkyl; R 15 is - (CR 1 R 2) n C OR 16, wherein n is 0, 1 or 2, - C NHCH(R 17)OR 16, or - C NHCH(R 17)C NHCH(R 18)C OR 16; R 16 is hydrogen, -C 1-6 alkyl, or -(CH 2) 1-2 N+R 19 R 20 R 21; R 1, R 2, R 4, R 5, R 6, R 7, R 9, R 10, R 17, R 18, R 19, R 20, and R 21 are independently hydrogen or -C 1-6 alkyl; or a compound selected from: and pharmaceutically acceptable salts thereof. R3 is hydrogen, deuterium, -OH, -OC 1-6 alkyl, or halogen; R 8 is hydrogen, deuterium, or -C 1-6 alkyl; R 11 and R 12 are independently hydrogen, -C 1-6 alkyl, -OH, -OC 1-6 alkyl, or halogen; R 13 and R 14 are independently -C 1-6 alkyl, -(CH 2) 1-2 OH, or -OC 1-6 alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or -C 1-6 alkyl; R 15 is - (CR 1 R 2) n C OR 16, wherein n is 0, 1 or 2, - C NHCH(R 17)OR 16, or - C NHCH(R 17)C NHCH(R 18)C OR 16; - (CR 1 R 2) n C OR 16, wherein n is 0, 1 or 2, - C NHCH(R 17)OR 16, or - C NHCH(R 17)C NHCH(R 18)C OR 16; R 16 is hydrogen, -C 1-6 alkyl, or -(CH 2) 1-2 N+R 19 R 20 R 21; R 1, R 2, R 4, R 5, R 6, R 7, R 9, R 10, R 17, R 18, R 19, R 20, and R 21 are independently hydrogen or -C 1-6 alkyl;
A compound, which compound is BCY6136 or a pharmaceutically acceptable salt thereof, wherein said compound BCY6136 has the structure: wherein BCY6099 is a polypeptide of SEQ ID NO: 2 (β-Ala)-Sar 10 -A(HArg)D-C i (HyP)LVNPLC ii LHP(D-Asp)W(HArg)C iii (SEQ ID NO: 2) wherein Sar is sarcosine, HArg is homoarginine and HyP is hydroxyproline; wherein the polypeptide of SEQ ID NO: 2 is cyclised at C i, C ii and C iii with 1,1',1"-(1,3,5-triazinane-1,3,5-triyl)triprop-2-en-1-one (TATA). wherein BCY6099 is a polypeptide of SEQ ID NO: 2 (β-Ala)-Sar 10 -A(HArg)D-C i (HyP)LVNPLC ii LHP(D-Asp)W(HArg)C iii (SEQ ID NO: 2) wherein Sar is sarcosine, HArg is homoarginine and HyP is hydroxyproline; wherein the polypeptide of SEQ ID NO: 2 is cyclised at C i, C ii and C iii with 1,1',1"-(1,3,5-triazinane-1,3,5-triyl)triprop-2-en-1-one (TATA).
A method for controlling clutch pressure in an electronically controlled limited slip differential, comprising: receiving a target clutch pressure command indicative of a desired differential torque transfer setting; processing the target clutch pressure command in a processing device comprising a processor, a memory, and processor-executable programming, characterised in that the processing comprises: estimating one of a motor current or a motor speed; calculating an integrated error of a target motor current or an integrated error of a target motor speed; processing the estimated motor current or the estimated motor speed and processing the integrated error of the target motor current or the integrated error of the target motor speed to calculate gains; applying the calculated gains to the target motor current or to the target motor speed thereby forming a closed loop feedback; and calculating an oscillation about the target motor current or about the target motor speed; and applying the target motor current or the target motor speed to a motor connected to a clutch in the differential according to the calculated oscillation to control the clutch pressure of the differential. receiving a target clutch pressure command indicative of a desired differential torque transfer setting; processing the target clutch pressure command in a processing device comprising a processor, a memory, and processor-executable programming, characterised in that the processing comprises: estimating one of a motor current or a motor speed; calculating an integrated error of a target motor current or an integrated error of a target motor speed; processing the estimated motor current or the estimated motor speed and processing the integrated error of the target motor current or the integrated error of the target motor speed to calculate gains; applying the calculated gains to the target motor current or to the target motor speed thereby forming a closed loop feedback; and calculating an oscillation about the target motor current or about the target motor speed; and estimating one of a motor current or a motor speed; calculating an integrated error of a target motor current or an integrated error of a target motor speed; processing the estimated motor current or the estimated motor speed and processing the integrated error of the target motor current or the integrated error of the target motor speed to calculate gains; applying the calculated gains to the target motor current or to the target motor speed thereby forming a closed loop feedback; and calculating an oscillation about the target motor current or about the target motor speed; and applying the target motor current or the target motor speed to a motor connected to a clutch in the differential according to the calculated oscillation to control the clutch pressure of the differential.
A method of reconditioning an intravascular device for reuse in a clinical procedure, comprising: reading first security data and first device data from a memory of the intravascular device, the first device data comprising performance parameters; determining if the intravascular device is authentic based on the first security data; permitting reconditioning of the intravascular device for reuse in a clinical procedure by generating second security data, when the intravascular device is authentic; evaluating change in performance parameters of the intravascular device; generating second device data comprising reuse instructions for the intravascular device that compensate for the identified change in performance parameters; and writing (414,420) the second device data and the second security data to the memory of the intravascular device, wherein the first and second security data include a message authentication code. reading first security data and first device data from a memory of the intravascular device, the first device data comprising performance parameters; determining if the intravascular device is authentic based on the first security data; permitting reconditioning of the intravascular device for reuse in a clinical procedure by generating second security data, when the intravascular device is authentic; evaluating change in performance parameters of the intravascular device; generating second device data comprising reuse instructions for the intravascular device that compensate for the identified change in performance parameters; and writing (414,420) the second device data and the second security data to the memory of the intravascular device, wherein the first and second security data include a message authentication code.
A conveyor frame (10, 110, 600) for supporting a conveyor belt traveling between a first end and a second end of the frame, comprising: a plurality of legs (18, 118, 618); a first longitudinally-extending rail (20, 120, 620) extending between and connecting a first leg and a second leg; and a second longitudinally-extending rail (20, 120, 620) extending between and connecting a third and a fourth leg, wherein the first and second longitudinally-extending rails form the carryway for the conveyor belt; a lateral leg connector (19; 119; 651) extending between the first leg and the third leg; and a lateral leg connector (19; 119; 651) extending between the second leg and the fourth leg; wherein the first and second longitudinally-extending rails (20, 120, 620), which also structurally support the frame, have curved ends (23, 24, 124, 621) integral with the respective linear portions that form reversing elements between the carryway and a returnway below the carryway; and curved longitudinally-extending returnway support rails (50, 150, 650) extending from the lateral leg connectors (19; 119; 651) for guiding said conveyor belt in the returnway; characterised in that the curved returnway support rails curve downwards such that, when in use, the curved returnway support rails allow for sagging of the conveyor belt in the returnway; and in that the curved returnway support rails are integral with the lateral leg connectors such that, when in use, the curved returnway support rails accommodate sagging of the conveyor belt in the returnway. a plurality of legs (18, 118, 618); a first longitudinally-extending rail (20, 120, 620) extending between and connecting a first leg and a second leg; and a second longitudinally-extending rail (20, 120, 620) extending between and connecting a third and a fourth leg, wherein the first and second longitudinally-extending rails form the carryway for the conveyor belt; a lateral leg connector (19; 119; 651) extending between the first leg and the third leg; and a lateral leg connector (19; 119; 651) extending between the second leg and the fourth leg; wherein the first and second longitudinally-extending rails (20, 120, 620), which also structurally support the frame, have curved ends (23, 24, 124, 621) integral with the respective linear portions that form reversing elements between the carryway and a returnway below the carryway; and curved longitudinally-extending returnway support rails (50, 150, 650) extending from the lateral leg connectors (19; 119; 651) for guiding said conveyor belt in the returnway; characterised in that the curved returnway support rails curve downwards such that, when in use, the curved returnway support rails allow for sagging of the conveyor belt in the returnway; and in that the curved returnway support rails are integral with the lateral leg connectors such that, when in use, the curved returnway support rails accommodate sagging of the conveyor belt in the returnway.
A method for creating a three-dimensional structure on at least one portion of a surface of an object, in which drops (12, 13) of a structure-forming mass are delivered by a delivery device of an application device controlled by a control device onto the surface of the object, and the object and the application device are moved relative to one another and the object is held in a positioned manner on a positioning device and the three-dimensional structure is subsequently hardened, wherein the position, number and/or the volume of the drops (12, 13) of the structure-forming mass are determined by the control device based on the three-dimensional structure in a plane that is parallel to a bearing surface of the positioning device for the object in different directions as well as in a direction transverse to said plane, and the drops (12, 13) are delivered in a positioned manner onto the surface of the object by means of the delivery device of the application device (4, 19), characterized in that the created three-dimensional structure is a three-dimensional structure having a plurality of layers of drops (12, 13) which are applied on top of one another, thus in the direction of a spatial axis or a height (40, 41, 42), and that the three-dimensional structure's height extending perpendicular to the bearing surface is created by varying the number of drops of the structure-forming mass per unit area of the surface of the object, wherein applying the drops on the surface of the object is carried out in only one pass, and wherein from the color information of a two-dimensional image, a height model for the three-dimensional structure is derived.
An atomiser for dispensing a fragrance; the atomiser comprising a) an outer housing; b) an orifice plate and piezo electric element; c) a liquid reservoir, comprising a liquid to be atomised, the liquid comprising a fragrance composition and a carrier solvent; and d) a liquid transport member; wherein the liquid transport member extends from within the liquid reservoir to abut the orifice plate; wherein the liquid transport member is a wick comprising paper, cotton, nylon, or polypropylene and is substantially contained within the liquid reservoir and both the wick and liquid reservoir are readily detachable together from the atomiser; wherein the liquid comprises: a) a fragrance composition 2-25% by weight and b) a carrier solvent 75-98% by weight; and wherein the carrier solvent comprises at least 50% by weight C11-C16 branched chain alkanes. a) an outer housing; b) an orifice plate and piezo electric element; c) a liquid reservoir, comprising a liquid to be atomised, the liquid comprising a fragrance composition and a carrier solvent; and d) a liquid transport member; wherein the liquid transport member extends from within the liquid reservoir to abut the orifice plate; wherein the liquid transport member is a wick comprising paper, cotton, nylon, or polypropylene and is substantially contained within the liquid reservoir and both the wick and liquid reservoir are readily detachable together from the atomiser; wherein the liquid comprises: a) a fragrance composition 2-25% by weight and b) a carrier solvent 75-98% by weight; and wherein the carrier solvent comprises at least 50% by weight C11-C16 branched chain alkanes. wherein the liquid transport member extends from within the liquid reservoir to abut the orifice plate; wherein the liquid transport member is a wick comprising paper, cotton, nylon, or polypropylene and is substantially contained within the liquid reservoir and both the wick and liquid reservoir are readily detachable together from the atomiser; wherein the liquid comprises: a) a fragrance composition 2-25% by weight and b) a carrier solvent 75-98% by weight; and a) a fragrance composition 2-25% by weight and b) a carrier solvent 75-98% by weight; and wherein the carrier solvent comprises at least 50% by weight C11-C16 branched chain alkanes.
A liner configured to provide an interface between a residual limb and a prosthetic socket, comprising: an elongate, generally conical liner body formed from at least one material segment that is at least radially elastically extensible from a relaxed non-extended condition and including proximal and distal end areas; wherein a seal component is connected to the liner body and has at least one exterior configuration defined along an exterior surface of the seal component for engaging a prosthetic socket and at least one interior configuration for movably engaging the liner body; characterized in that the at least one interior configuration, of said seal component, defines a plurality of blades arranged for engaging an exterior surface of the liner body. an elongate, generally conical liner body formed from at least one material segment that is at least radially elastically extensible from a relaxed non-extended condition and including proximal and distal end areas; wherein a seal component is connected to the liner body and has at least one exterior configuration defined along an exterior surface of the seal component for engaging a prosthetic socket and at least one interior configuration for movably engaging the liner body; characterized in that the at least one interior configuration, of said seal component, defines a plurality of blades arranged for engaging an exterior surface of the liner body.
Valve, in particular proportional pressure control valve, with a spring-loaded valve piston, which is guided longitudinally in travel within a valve body by an energisable actuating solenoid and which, depending on its travel position, makes a fluid-carrying connection, or closes it again, between a pump connection and a working connection as well as between this working connection and a tank connection in the valve body, wherein the opposing end faces of the valve piston are permanently subjected to the pressure of the tank connection and wherein the valve piston has a pressure-active control surface, which can open have a fluid-carrying link to the working connection to create the control pressure, and with an annular space in the valve body, into which the working connection opens in radial or axial direction, characterised in that on the valve piston, at the position of the transition between the annular space and the inlet of the working connection, the pressure-active control surface is configured so that a maximum control pressure can be produced in the de-energised state of the actuating solenoid in which a respective control state is produced between the force of a compression spring of the spring-loaded valve piston and the control pressure (P R) arising at the control surface of the valve piston.
Blade rotor for a mowing apparatus, with a mowing disc, at least one mowing blade, at least one bearing pin, which is fastened to the mowing disc, for the pivotable mounting of the mowing blade, and a spring sheet, which is arranged on the mowing disc, for holding the mowing blade on the bearing pin, characterized in that a fastening hole, into which the bearing pin is screwable into the fastening hole from a side of the mowing disc that faces away from the spring sheet, is provided in or on the mowing disc, wherein a threaded region and a holding region are formed on the bearing pin, and the holding region can be introduced when the bearing pin is screwed through the fastening hole and can be brought into engagement with the spring sheet.
A method for cleaning a substrate which is or comprises a textile, the method comprising agitating the substrate and a cleaning composition comprising: i. cleaning particles comprising a thermoplastic polyamide and a hydrophilic material at least part of which is located inside the cleaning particle, said cleaning particles having an average particle size of from 1 to 100 mm; and ii. an aqueous liquid medium, wherein the hydrophilic material is or comprises a surfactant, a dye transfer inhibitor or a builder, or wherein the hydrophilic material is or comprises a polyether. i. cleaning particles comprising a thermoplastic polyamide and a hydrophilic material at least part of which is located inside the cleaning particle, said cleaning particles having an average particle size of from 1 to 100 mm; and ii. an aqueous liquid medium,
A peptide for use in treating or preventing HCV infection, or inhibiting the replication of HCV in a subject, wherein the peptide comprises an amino acid sequence having at least 70% identity to the amino acid sequence DEAQETAVSSHEQD or fragments thereof.
A communication apparatus for a vehicle (100, 100a), comprising: an interface unit configured to receive sensing information regarding a first other vehicle from an object detection apparatus not part of the communication apparatus and configured to generate the sensing information by sensing the first other vehicle located in a vicinity of the vehicle (100, 100a) and incapable of performing vehicle-to-vehicle communication; a receiver configured to receive information from a plurality of other vehicles; a transmitter configured to transmit information to a second other vehicle capable of performing vehicle-to-vehicle communication; and a processor configured to generate recognition information for the first other vehicle based on the sensing information, and transmit the recognition information for the first other vehicle to the second other vehicle through the transmitter, characterised in that 11 the processor is further configured to:. receive, through the receiver, recognition information for the first other vehicle from the plurality of other vehicles; and determine reliability of the received recognition information for the first other vehicle, based on at least one of communication strength, information on a type of a sensor sensing the first other vehicle, and information on a position where the sensor sensing the first other vehicle is attached. an interface unit configured to receive sensing information regarding a first other vehicle from an object detection apparatus not part of the communication apparatus and configured to generate the sensing information by sensing the first other vehicle located in a vicinity of the vehicle (100, 100a) and incapable of performing vehicle-to-vehicle communication; a receiver configured to receive information from a plurality of other vehicles; a transmitter configured to transmit information to a second other vehicle capable of performing vehicle-to-vehicle communication; and a processor configured to generate recognition information for the first other vehicle based on the sensing information, and transmit the recognition information for the first other vehicle to the second other vehicle through the transmitter, characterised in that 11 the processor is further configured to:. receive, through the receiver, recognition information for the first other vehicle from the plurality of other vehicles; and determine reliability of the received recognition information for the first other vehicle, based on at least one of communication strength, information on a type of a sensor sensing the first other vehicle, and information on a position where the sensor sensing the first other vehicle is attached. receive, through the receiver, recognition information for the first other vehicle from the plurality of other vehicles; and determine reliability of the received recognition information for the first other vehicle, based on at least one of communication strength, information on a type of a sensor sensing the first other vehicle, and information on a position where the sensor sensing the first other vehicle is attached.