A medical coupling for fluid-tight connection of two fluid-guiding portions in medical applications, wherein the coupling is an axially lockable quick-connect coupling and comprises a male coupling portion (6") configured as a cylindrical projection having a continuous, internal first passage (10"), and a female coupling portion (4") adapted to be slipped over the male coupling portion (6") and having a continuous second passage, and wherein the male coupling portion (6") and the female coupling portion (4") are lockable to each other; and a circumferential radial sealing is provided on the outer periphery of the male coupling portion (6") and/or on the inner periphery of the female coupling portion (4"), characterized in that the male coupling portion (6") has a groove, and the male coupling portion (6") has, at an end remote from the female coupling portion (4"), a stop or shoulder which extends outwards in the radial direction and is provided to limit the movement of the female coupling portion (4") in the axial direction, wherein the male coupling portion (6") and the female coupling portion (4") are connectable to or disconnectable from each other by a release device, wherein the release device in a locked state comprises a lever parallel to a longitudinal axis of the medical coupling and a pin perpendicular to the longitudinal axis, wherein the lever is hingedly connected at its end facing the male coupling portion (6") to a radially outer end of the pin, wherein the pin is actuatable by an articulated movement of the lever via an articulation point in order to push into or move out of the groove, so that the male coupling portion (6") and the female coupling portion (4") are connectable to or disconnectable from each other, and wherein the unlocking device is provided on the female coupling portion (4"). the coupling is an axially lockable quick-connect coupling and comprises a male coupling portion (6") configured as a cylindrical projection having a continuous, internal first passage (10"), and a female coupling portion (4") adapted to be slipped over the male coupling portion (6") and having a continuous second passage, and wherein the male coupling portion (6") and the female coupling portion (4") are lockable to each other; and a circumferential radial sealing is provided on the outer periphery of the male coupling portion (6") and/or on the inner periphery of the female coupling portion (4"), characterized in that the male coupling portion (6") has a groove, and the male coupling portion (6") has, at an end remote from the female coupling portion (4"), a stop or shoulder which extends outwards in the radial direction and is provided to limit the movement of the female coupling portion (4") in the axial direction, wherein the male coupling portion (6") and the female coupling portion (4") are connectable to or disconnectable from each other by a release device, wherein the release device in a locked state comprises a lever parallel to a longitudinal axis of the medical coupling and a pin perpendicular to the longitudinal axis, wherein the lever is hingedly connected at its end facing the male coupling portion (6") to a radially outer end of the pin, wherein the pin is actuatable by an articulated movement of the lever via an articulation point in order to push into or move out of the groove, so that the male coupling portion (6") and the female coupling portion (4") are connectable to or disconnectable from each other, and wherein the unlocking device is provided on the female coupling portion (4").