A vascular catheter comprising: - a catheter shaft having a distal end, a proximal end and a longitudinal axis therebetween, adapted to reach at least a predefined position in a blood vessel in a patient; - a catheter handle at the proximal end of the catheter shaft; - at least two occlusion elements (42, 43) fitted onto the catheter shaft adapted to act as an occluder to isolate an isolated volume of the blood vessel longitudinally interposed between said at least two occlusion elements (42, 43); - an expandable balloon, longitudinally interposed between the two occlusion elements (42, 43) and adapted to act as a core to occupy a first portion of the isolated volume of the blood vessel, defining a second portion of isolated volume radially externally contouring the wall of the expandable balloon; wherein: - the vascular catheter comprises at least two delivery and return catheter paths (11, 12, 13), independent from each other, which define in the vascular catheter at least a first path and at least a second path, distinct from the first path; and wherein: - the catheter shaft comprises a first hole which opens into the at least one expandable balloon adapted to act as a core; - the first hole is in fluid communication with said first path; - the catheter handle comprises a first pumping device associated with the first path and associable with a first collection and storage tank containing a first fluid; and wherein: the catheter shaft comprises a second hole which opens out of the at least one expandable balloon so as to be adapted to lead into said second portion of said isolated volume; - the second hole is in fluid communication with said second path; - the catheter handle comprises a second pumping device associated with the second path and associable with a second collection and storage tank containing a second, pharmacological fluid which contains drug; characterised in that, the catheter handle comprises a synchronization device operatively connectable both to the first pumping device and to the second pumping device, so that when said synchronization device is operatively connected to both said first pumping device and said second pumping device, the catheter handle can deliver in said isolated volume a predetermined volume of second, pharmacological fluid out of the at least one expandable balloon simultaneously causing a reduction in volume of the expandable balloon by an equal predetermined volume; and wherein both said first tank and said second tank act as a collection tank and a storage tank for the respective fluid, said first and second paths (P1, P2) allowing the respective fluid to travel in both directions, so that the catheter shaft can be repositioned in various portions of the blood vessel having different caliber to create said isolated volume. - a catheter shaft having a distal end, a proximal end and a longitudinal axis therebetween, adapted to reach at least a predefined position in a blood vessel in a patient; - a catheter handle at the proximal end of the catheter shaft; - at least two occlusion elements (42, 43) fitted onto the catheter shaft adapted to act as an occluder to isolate an isolated volume of the blood vessel longitudinally interposed between said at least two occlusion elements (42, 43); - an expandable balloon, longitudinally interposed between the two occlusion elements (42, 43) and adapted to act as a core to occupy a first portion of the isolated volume of the blood vessel, defining a second portion of isolated volume radially externally contouring the wall of the expandable balloon; - the vascular catheter comprises at least two delivery and return catheter paths (11, 12, 13), independent from each other, which define in the vascular catheter at least a first path and at least a second path, distinct from the first path; - the catheter shaft comprises a first hole which opens into the at least one expandable balloon adapted to act as a core; - the first hole is in fluid communication with said first path; - the catheter handle comprises a first pumping device associated with the first path and associable with a first collection and storage tank containing a first fluid; the catheter shaft comprises a second hole which opens out of the at least one expandable balloon so as to be adapted to lead into said second portion of said isolated volume; - the second hole is in fluid communication with said second path; - the catheter handle comprises a second pumping device associated with the second path and associable with a second collection and storage tank containing a second, pharmacological fluid which contains drug; - the second hole is in fluid communication with said second path; - the catheter handle comprises a second pumping device associated with the second path and associable with a second collection and storage tank containing a second, pharmacological fluid which contains drug; characterised in that, the catheter handle comprises a synchronization device operatively connectable both to the first pumping device and to the second pumping device, so that when said synchronization device is operatively connected to both said first pumping device and said second pumping device, the catheter handle can deliver in said isolated volume a predetermined volume of second, pharmacological fluid out of the at least one expandable balloon simultaneously causing a reduction in volume of the expandable balloon by an equal predetermined volume;