mhurhangee/ep-ind-claims huggingface dataset:
A zinc finger protein comprising a non-canonical (non-C2H2) zinc finger, wherein the non-canonical zinc finger has a helical portion involved in DNA binding and wherein at least one zinc finger comprises the sequence Cys-(X A) 2-4 -Cys-(X B) 12 -His-(X C) 3-5 -Cys-(X D) 1-10 (SEQ ID NO:3), where X A, X B, X C and X D can be any amino acid and His-(X C) 3-5 -Cys(X D) 1-10 comprises one of the sequences as shown in any of SEQ ID NOs:14-80, 83-87 and 89-92 and further wherein the zinc finger protein is engineered to bind to a target sequence.
A method for estimating the thermal resistivity of soil surrounding an underground cable, the method being performed by a thermal resistivity estimating unit and comprising: obtaining (S100; S110; S120) a first temperature (T s) from a first temperature sensor at an exterior surface of the cable, obtaining (S102; s112) a second temperature (T a) from a second temperature sensor placed in the soil at a distance from the cable, obtaining (S104; S114) a measurement of current (I c) transmitted in the cable, and estimating (S106; S116, S118, S120, S122, S124, S126) the thermal resistivity of soil based on the first and the second temperatures (T s, T a) as well as on the current measurement (I c), characterized in that the estimation of the thermal resistivity of the soil is based on a difference between an estimate of the temperature at the exterior surface of the cable caused by power losses in the cable when the measured current (I c) is running in the cable and the measured temperature at the exterior surface of the cable, and the estimation of the thermal resistivity of the soil is iterative and involves predicting a following thermal resistivity of the soil based on a combination of a previous thermal resistivity of the soil and the difference between the estimated temperature and the measured temperature at the exterior surface of the cable. obtaining (S100; S110; S120) a first temperature (T s) from a first temperature sensor at an exterior surface of the cable, obtaining (S102; s112) a second temperature (T a) from a second temperature sensor placed in the soil at a distance from the cable, obtaining (S104; S114) a measurement of current (I c) transmitted in the cable, and estimating (S106; S116, S118, S120, S122, S124, S126) the thermal resistivity of soil based on the first and the second temperatures (T s, T a) as well as on the current measurement (I c), characterized in that the estimation of the thermal resistivity of the soil is based on a difference between an estimate of the temperature at the exterior surface of the cable caused by power losses in the cable when the measured current (I c) is running in the cable and the measured temperature at the exterior surface of the cable, and the estimation of the thermal resistivity of the soil is iterative and involves predicting a following thermal resistivity of the soil based on a combination of a previous thermal resistivity of the soil and the difference between the estimated temperature and the measured temperature at the exterior surface of the cable.
Computer-implemented method for allocating columns of a table stored in a database system into at least two sets of columns, a first set and a second set, the data of the columns allocated to the first set being stored on a primary storage medium using a column-oriented data structure and the data of columns allocated to the second set being stored on a secondary storage medium using a row-oriented data structure, characterized in that the method comprises the step of allocating the columns of the table to the first and the second set autonomously on the basis of a performance-cost model, wherein the step of allocating the columns comprises the step of: iteratively adding columns to the first set so that, in each iteration, a column is added to the first set that - has not been added in a previous iteration and that, - in accordance with the performance-cost-model, provides the largest performance gain per occupied space on the primary storage medium if it is added to the first set. the data of the columns allocated to the first set being stored on a primary storage medium using a column-oriented data structure and the data of columns allocated to the second set being stored on a secondary storage medium using a row-oriented data structure, characterized in that the method comprises the step of allocating the columns of the table to the first and the second set autonomously on the basis of a performance-cost model, wherein the step of allocating the columns comprises the step of: iteratively adding columns to the first set so that, in each iteration, a column is added to the first set that - has not been added in a previous iteration and that, - in accordance with the performance-cost-model, provides the largest performance gain per occupied space on the primary storage medium if it is added to the first set. - has not been added in a previous iteration and that, - in accordance with the performance-cost-model, provides the largest performance gain per occupied space on the primary storage medium if it is added to the first set.
A composition for use in the treatment of amyotrophic lateral sclerosis, wherein said composition comprises a pharmaceutically acceptable vehicle and an agent selected from: an isolated exogenous antibody or fragment thereof that binds selectively to a disease specific epitope selected from: i) DLGKGGNEESTKTGNAGS (SEQ ID NO:2) or CDLGKGGNEESTKTGNAGS (SEQ ID NO: 11), ii) CIKGLTEGLHGF (SEQ ID NO:14) or IKGLTEGLHGF (SEQ ID NO:5); and iii) GLHGFHVH (SEQ ID NO:7); and/or iv) a disease specific epitope of any one of i), ii) or iii) comprising one or more oxidized or nitrated amino acids; and/or an immunogen comprising a peptide consisting of the amino acid sequence of any one of SEQ ID NO: 2, 5, 7, 11, 14, said peptide comprising up to 50 SOD1 residues, or an immunogen of comprising one or more oxidized or nitrated amino acids. an isolated exogenous antibody or fragment thereof that binds selectively to a disease specific epitope selected from: i) DLGKGGNEESTKTGNAGS (SEQ ID NO:2) or CDLGKGGNEESTKTGNAGS (SEQ ID NO: 11), ii) CIKGLTEGLHGF (SEQ ID NO:14) or IKGLTEGLHGF (SEQ ID NO:5); and iii) GLHGFHVH (SEQ ID NO:7); and/or iv) a disease specific epitope of any one of i), ii) or iii) comprising one or more oxidized or nitrated amino acids; and/or i) DLGKGGNEESTKTGNAGS (SEQ ID NO:2) or CDLGKGGNEESTKTGNAGS (SEQ ID NO: 11), ii) CIKGLTEGLHGF (SEQ ID NO:14) or IKGLTEGLHGF (SEQ ID NO:5); and iii) GLHGFHVH (SEQ ID NO:7); and/or iv) a disease specific epitope of any one of i), ii) or iii) comprising one or more oxidized or nitrated amino acids; and/or an immunogen comprising a peptide consisting of the amino acid sequence of any one of SEQ ID NO: 2, 5, 7, 11, 14, said peptide comprising up to 50 SOD1 residues, or an immunogen of comprising one or more oxidized or nitrated amino acids.
An optical element comprising: a substrate; and a silica film disposed on the substrate, wherein the silica film has a first surface and a second surface, the first and second surfaces being opposite to each other, the silica film includes silica and fluorinated hollow silica particles, the fluorinated hollow silica particles are unevenly distributed with a greater concentration toward the first surface, and the first surface of the silica film has a convex-concave structure, wherein the fluorinated hollow silica particles comprise two or more sets of particles, wherein the sets of particles have particle size distributions which are different from each other. a substrate; and a silica film disposed on the substrate, wherein the silica film has a first surface and a second surface, the first and second surfaces being opposite to each other, the silica film includes silica and fluorinated hollow silica particles, the fluorinated hollow silica particles are unevenly distributed with a greater concentration toward the first surface, and the first surface of the silica film has a convex-concave structure, wherein the fluorinated hollow silica particles comprise two or more sets of particles, wherein the sets of particles have particle size distributions which are different from each other.
Heat pump system comprising a heat medium circuit (210,220,230,240,250,310,320,410,420,430,440,450,460) in turn comprising a compressor, an expansion valve (232,242), at least one primary heat exchanging means (422,433,452) arranged to transfer thermal energy between a primary-side heat medium and a respective primary heat source or sink selected from outdoor air, a water body or the ground, at least two secondary heat exchanging means (314,315,316) arranged to transfer thermal energy between a secondary-side heat medium and a respective secondary heat source or sink selected from indoors air, pool water, water and a topmost outdoor ground layer, a valve means (311,312,313) arranged to selectively direct the secondary-side heat medium to one or several of said secondary heat exchanging means, and a control means, wherein the speed of the compressor can be controlled, wherein an opening of the expansion valve is adjustable, and wherein the control means is arranged to control the power of the heat pump system by controlling the speed of the compressor, characterised in that the control means is arranged to control an output temperature of heat medium flowing out from the expansion valve by controlling the opening of the expansion valve given the controlled speed of the compressor and based upon information regarding to which secondary heat exchanging means the secondary-side heat medium is directed. a compressor, an expansion valve (232,242), at least one primary heat exchanging means (422,433,452) arranged to transfer thermal energy between a primary-side heat medium and a respective primary heat source or sink selected from outdoor air, a water body or the ground, at least two secondary heat exchanging means (314,315,316) arranged to transfer thermal energy between a secondary-side heat medium and a respective secondary heat source or sink selected from indoors air, pool water, water and a topmost outdoor ground layer, a valve means (311,312,313) arranged to selectively direct the secondary-side heat medium to one or several of said secondary heat exchanging means, and a control means,
A delamination container formed in a shape including a tubular mouth and a trunk contiguous with the mouth, the delamination container comprising: an outer layer body formed of a resin material; an inner layer body that is formed of a resin material and that is disposed on an inner side of the outer layer body in a manner such that the inner layer body is peelable from the outer layer body; and an intermediate layer that is formed of a resin material different from the resin materials forming the outer layer body and the inner layer body and that is disposed between the outer layer body and the inner layer body, wherein the outer layer body, the inner layer body, and the intermediate layer are formed by direct-blow molding a laminated parison including resin layers corresponding to the outer layer body, the inner layer body, and the intermediate layer, and at an opening end of the mouth, an end portion of the intermediate layer is covered by the outer layer body and the inner layer body, characterized in that the mouth is integrally provided, on an outer circumferential surface thereof, with an annular ring-shaped moil cut portion including a downwardly extending tapered surface inclined with respect to an axis direction of the mouth, and in the mouth, the end portion of the intermediate layer is bent to an outer side in a radial direction toward the moil cut portion. an outer layer body formed of a resin material; an inner layer body that is formed of a resin material and that is disposed on an inner side of the outer layer body in a manner such that the inner layer body is peelable from the outer layer body; and an intermediate layer that is formed of a resin material different from the resin materials forming the outer layer body and the inner layer body and that is disposed between the outer layer body and the inner layer body, wherein the outer layer body, the inner layer body, and the intermediate layer are formed by direct-blow molding a laminated parison including resin layers corresponding to the outer layer body, the inner layer body, and the intermediate layer, and
An endoscope system, comprising: an illumination unit adapted to irradiate a specimen with first and second illumination light having different spectral characteristics; an endoscope including a CMOS type imaging element adapted to image the specimen illuminated by the illumination unit using a plurality of pixel rows arranged in a column direction; a control unit adapted to cause the illumination unit and the imaging element to execute a first imaging scheme for resetting some of the plurality of pixel rows en bloc after the specimen is irradiated with the first illumination light from the illumination unit, turning off the illumination unit after the specimen is irradiated with the second illumination light from the illumination unit, and performing signal reading from all of the pixel rows; and an image processing unit adapted to generate a normal observation image on the basis of a first imaging signal read from the pixel row exposed by the first and second illumination light without being subjected to the resetting, and generates a special observation image on the basis of a second imaging signal read from the pixel row at least subjected to the resetting and exposed by only the second illumination light. an illumination unit adapted to irradiate a specimen with first and second illumination light having different spectral characteristics; an endoscope including a CMOS type imaging element adapted to image the specimen illuminated by the illumination unit using a plurality of pixel rows arranged in a column direction; a control unit adapted to cause the illumination unit and the imaging element to execute a first imaging scheme for resetting some of the plurality of pixel rows en bloc after the specimen is irradiated with the first illumination light from the illumination unit, turning off the illumination unit after the specimen is irradiated with the second illumination light from the illumination unit, and performing signal reading from all of the pixel rows; and an image processing unit adapted to generate a normal observation image on the basis of a first imaging signal read from the pixel row exposed by the first and second illumination light without being subjected to the resetting, and generates a special observation image on the basis of a second imaging signal read from the pixel row at least subjected to the resetting and exposed by only the second illumination light.
Sheet flipping device, comprising a receiving member for receiving a sheet, a flipping volume being substantially the volume which in operation is defined by the flipping movement of the sheet, a flipping element for flipping the sheet around an axis of rotation within the flipping volume onto the receiving member, wherein the sheet flipping device further comprises a discharge element arranged adjacent to said flipping volume, characterized in that the discharge element has a base in a lateral position with respect to the flipping volume and extending in a direction substantially perpendicular to the direction of the axis of rotation and having multiple electrodes with an end portion extending in a direction towards the flipping volume.
Apparatus for bone densitometry, comprising: - a patient-carrier frame with a support surface comprising a scanning area and being configured to support a lying patient; - an arm movable with respect to the patient-carrier frame in a longitudinal direction by means of a longitudinal movement system, from the feet to the head of the patient lying on the support surface, and comprising a generator-detector assembly comprising an X-ray generator and an X-ray detector, which are mechanically aligned so that the collimated beam of X-rays produced by the generator centres the X-ray detector; - a control unit which is configured to implement Dual Energy X-ray Absorptiometry (DEXA); characterised in that the patient-carrier frame is a monocoque, that is a single rigid structure with bearing function, and consists of a single sheet of aluminium,which has been folded to form the patient-carrier table, and which fully supports the arm, in that the longitudinal movement system is attached to a lower side of the support surface, which is opposite to the side on which the patient lies, in order to leave the space underneath the patient-carrier frame free, and in that the scanning area is formed by reducing the thickness of the frame to create a filtering portion for the X-rays. - a patient-carrier frame with a support surface comprising a scanning area and being configured to support a lying patient; - an arm movable with respect to the patient-carrier frame in a longitudinal direction by means of a longitudinal movement system, from the feet to the head of the patient lying on the support surface, and comprising a generator-detector assembly comprising an X-ray generator and an X-ray detector, which are mechanically aligned so that the collimated beam of X-rays produced by the generator centres the X-ray detector; - a control unit which is configured to implement Dual Energy X-ray Absorptiometry (DEXA);
A method for detecting soft faults in a transmission line comprising the following steps: - acquiring a measurement signal, called time-domain reflectogram, characteristic of the reflection of a reference signal previously injected into the line, - calculating the integral of the time-domain reflectogram, - selecting, from the samples of the integral of the time-domain reflectogram, a first sample P1, a second sample P 2, delayed by a first delay k 1 relative to the first sample P 1, and a third sample P 3, delayed by a second delay k 2 relative to the second sample P 2, - calculating a first distance equal to the difference in absolute value between the value of the second sample P 2 and the value of either one of the first sample P 1 or of the third sample P 3, - calculating a second distance equal to the difference in absolute value between the value of the first sample P 1 and of the third sample P 3, - performing a first comparison of the first distance to the second distance weighted by a weighting coefficient β, - deducing from the result of the first comparison a piece of information on the existence of a soft fault at a position of the cable corresponding to the time-domain abscissa of the second sample P 2. - acquiring a measurement signal, called time-domain reflectogram, characteristic of the reflection of a reference signal previously injected into the line, - calculating the integral of the time-domain reflectogram, - selecting, from the samples of the integral of the time-domain reflectogram, a first sample P1, a second sample P 2, delayed by a first delay k 1 relative to the first sample P 1, and a third sample P 3, delayed by a second delay k 2 relative to the second sample P 2, - calculating a first distance equal to the difference in absolute value between the value of the second sample P 2 and the value of either one of the first sample P 1 or of the third sample P 3, - calculating a second distance equal to the difference in absolute value between the value of the first sample P 1 and of the third sample P 3, - performing a first comparison of the first distance to the second distance weighted by a weighting coefficient β, - deducing from the result of the first comparison a piece of information on the existence of a soft fault at a position of the cable corresponding to the time-domain abscissa of the second sample P 2.
A method for detecting a raise gesture in a wrist-wearable device, the method comprising: obtaining, at a motion coprocessor in the wrist-wearable device, a set of motion-sensor data samples from an internal motion sensor of the wrist-wearable device, the set of motion-sensor data samples corresponding to a time interval; determining, by the motion coprocessor, based on the set of motion-sensor data samples, a starting pose reflecting the orientation of the device and corresponding to a beginning of the time interval; selecting, by the motion coprocessor, based at least in part on the starting pose, a set of criteria for identifying a possible raise gesture using the set of motion-sensor data samples, wherein different sets of criteria are defined for different starting poses; identifying, by the motion coprocessor, the possible raise gesture based at least in part on whether the set of motion-sensor data samples satisfies the selected set of criteria; waking, by the motion coprocessor, an applications processor of the wrist-wearable device from a sleep state in response to identifying the possible raise gesture; identifying, by the motion coprocessor, a detected raise gesture in the event that the possible raise gesture is followed by at least a minimum period of time during which the device holds an approximately constant position in a focus pose corresponding to a particular orientation of the device; and activating a display of the wrist-wearable device in response to identifying a detected raise gesture. obtaining, at a motion coprocessor in the wrist-wearable device, a set of motion-sensor data samples from an internal motion sensor of the wrist-wearable device, the set of motion-sensor data samples corresponding to a time interval; determining, by the motion coprocessor, based on the set of motion-sensor data samples, a starting pose reflecting the orientation of the device and corresponding to a beginning of the time interval; selecting, by the motion coprocessor, based at least in part on the starting pose, a set of criteria for identifying a possible raise gesture using the set of motion-sensor data samples, wherein different sets of criteria are defined for different starting poses; identifying, by the motion coprocessor, the possible raise gesture based at least in part on whether the set of motion-sensor data samples satisfies the selected set of criteria; waking, by the motion coprocessor, an applications processor of the wrist-wearable device from a sleep state in response to identifying the possible raise gesture; identifying, by the motion coprocessor, a detected raise gesture in the event that the possible raise gesture is followed by at least a minimum period of time during which the device holds an approximately constant position in a focus pose corresponding to a particular orientation of the device; and activating a display of the wrist-wearable device in response to identifying a detected raise gesture.
A multi-stage compressor device for compressing gas, which compressor device mainly consists of at least two compressor elements placed in series one after the other, at least one of which forms a high-pressure compressor element that is driven by a motor and is of the screw type, and at least one other compressor element forms a low-pressure compressor element that is of the centrifugal type and is driven separately, in other words without any mechanical link with said motor, by means of an expander characterized in that the expander belongs to a closed power cycle with a circulating medium inside which is heated by the compressed gas coming from the high-pressure compressor element, in that the medium in the closed power cycle is pumped around by means of a pump, successively through: a heater which is made up of at least one heat exchanger through which at least part of the compressed gas flows; said expander which is connected with said compressor element; and a condenser, and in that the compressor device has a drive in the form of a thermal motor with an outlet line for the exhaust gases and that the heater in the closed power cycle has an additional heat exchanger, which is included in said outlet line.