A system for detecting biomedical parameters from a subject seated on a toilet seat, comprising: a toilet seat assembly comprising at least a toilet seat; a sensory unit comprising one or more electronic sensor modules configured to detect data from a user seated on the toilet seat in a normal position of use; a control unit connected to the sensory unit to receive data therefrom; and a power supply unit to supply power to the sensory unit and the control unit; wherein the sensor modules comprise at least a contact measurement module having at least one sensor defining a direct interface with the user body for acquiring ECG signals from the user; and an ECG (electrocardiography) module, configured to process ECG signals received from the contact measurement module; and wherein the sensor of the contact measurement module comprises a pair of sensor terminals positioned on the toilet seat so as to be in direct contact with respective thighs of the user seated on the toilet seat in a normal position of use; the sensor being configured to detect an electrical potential difference measured between said two terminals in contact with the body of the user; characterized in that the contact measurement module comprises only two terminals, positioned on opposite sides of the toilet seat and of a central axis thereof, in positions corresponding to the left and right thighs of the user seated on the toilet seat; the two terminals being separated by one or more insulating elements positioned between the terminals in the toilet seat; and in that the ECG module is configured to perform signal transduction and conditioning with virtual ground of the ECG signals received from the contact measurement module, the ECG module having an electronic circuit configured so as to generate a virtual ground signal, i.e. to provide a virtual reference voltage, enabling the use of only two measurement terminals for the acquisition of ECG signals. wherein the sensor modules comprise at least a contact measurement module having at least one sensor defining a direct interface with the user body for acquiring ECG signals from the user; and an ECG (electrocardiography) module, configured to process ECG signals received from the contact measurement module; and wherein the sensor of the contact measurement module comprises a pair of sensor terminals positioned on the toilet seat so as to be in direct contact with respective thighs of the user seated on the toilet seat in a normal position of use; the sensor being configured to detect an electrical potential difference measured between said two terminals in contact with the body of the user; characterized in that the contact measurement module comprises only two terminals, positioned on opposite sides of the toilet seat and of a central axis thereof, in positions corresponding to the left and right thighs of the user seated on the toilet seat; the two terminals being separated by one or more insulating elements positioned between the terminals in the toilet seat; and in that the ECG module is configured to perform signal transduction and conditioning with virtual ground of the ECG signals received from the contact measurement module, the ECG module having an electronic circuit configured so as to generate a virtual ground signal, i.e. to provide a virtual reference voltage, enabling the use of only two measurement terminals for the acquisition of ECG signals.