A compound of Formula: wherein: • Z is -N- or >CH; • R 1 is -H or -C 1-4 alkyl; • Ar 1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two R a moieties; where each R a moiety is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH, -S 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b)R c, -SO 2 NR b R c, -NR b SO 2 R c, -C(=O)NR b R c, -NO 2, and -CN, wherein R b and R c are each independently -H or -C 1 - 4 alkyl; and • Ar 2 is: phenyl fused at two adjacent ring carbon atoms to a group selected from the group consisting of -(CH 2) 3-5 - having 0 or 1 double bonds, -(CH 2) 2-3 O-, -OCH 2 CH 2 O-, and -OCF 2 O- to form a fused ring structure; or phenyl substituted on adjacent ring carbon atoms with -OCH 2 O- to form 4-benzo[1,3]dioxolyl; each phenyl moiety further unsubstituted or substituted with one, two, or three R e substituents, wherein each R e substituent is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH, -S 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b)R c, -SO 2 NR b R c, -NR b SO 2 R c, -C(=O)NR b R c, -NO 2, and -CN, wherein R b and R c as previously defined; or a pharmaceutically acceptable salt of such compound. • Z is -N- or >CH; • R 1 is -H or -C 1-4 alkyl; • Ar 1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two R a moieties; where each R a moiety is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH, -S 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b)R c, -SO 2 NR b R c, -NR b SO 2 R c, -C(=O)NR b R c, -NO 2, and -CN, wherein R b and R c are each independently -H or -C 1 - 4 alkyl; and • Ar 2 is: phenyl fused at two adjacent ring carbon atoms to a group selected from the group consisting of -(CH 2) 3-5 - having 0 or 1 double bonds, -(CH 2) 2-3 O-, -OCH 2 CH 2 O-, and -OCF 2 O- to form a fused ring structure; or phenyl substituted on adjacent ring carbon atoms with -OCH 2 O- to form 4-benzo[1,3]dioxolyl; each phenyl moiety further unsubstituted or substituted with one, two, or three R e substituents, wherein each R e substituent is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH, -S 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b)R c, -SO 2 NR b R c, -NR b SO 2 R c, -C(=O)NR b R c, -NO 2, and -CN, wherein R b and R c as previously defined; phenyl fused at two adjacent ring carbon atoms to a group selected from the group consisting of -(CH 2) 3-5 - having 0 or 1 double bonds, -(CH 2) 2-3 O-, -OCH 2 CH 2 O-, and -OCF 2 O- to form a fused ring structure; or phenyl substituted on adjacent ring carbon atoms with -OCH 2 O- to form 4-benzo[1,3]dioxolyl; each phenyl moiety further unsubstituted or substituted with one, two, or three R e substituents, wherein each R e substituent is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo, -CF 3, -OCF 3, -SCF 3, -SH, -S 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b)R c, -SO 2 NR b R c, -NR b SO 2 R c, -C(=O)NR b R c, -NO 2, and -CN, wherein R b and R c as previously defined;