A compound of Formula: wherein: A is O, or S; R 0 is H, or C alkyl; wherein said C alkyl is optionally substituted with OH, C alkyl-(OCH 2 CH 2) n -OCH 3, OCH 3, CO 2 H, C NH 2, SO 2 NH 2, or CO 2 C alkyl; n is 1, 2, or 3; R 1 is cyclohexyl, or tetrahydropyranyl; wherein said cyclohexyl or tetrahydropyranyl may be optionally substituted with one substituent selected from the group consisting of: OCH 3, OH, CH 2 CH 3, -CN, NH 2, NH(CH 3), N(CH 3) 2, or OCF 3; alternatively, R 0 and R 1 are taken together with their attached nitrogen to form a ring selected from the group consisting of R a is phenyl; wherein the phenyl is optionally substituted with C NH 2, C NHC alkyl, SO 2 NH 2, C N(C alkyl) 2, OCH 3, CO 2 CH 3, or CO 2 H; R b is C alkyl, or OC alkyl; R 2 is selected from the group consisting of H, C alkyl, cyclopropyl, cyclohexyl, phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, furyl, and thiophenyl; wherein said phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, furyl, or thiophenyl is optionally substituted with one substituent selected from the group consisting of NH 2, NHC alkyl, N(C alkyl) 2, C alkyl, -CN, -CH=CH 2, -CONH 2, -CO 2 H, -NO 2, -CONHC alkyl, CON(C alkyl) 2, C alkylCONH 2, -NHCOC alkyl, -CO 2 C alkyl, CF 3, SO 2 C alkyl, -SO 2 NH 2,-SO 2 NH(C alkyl), and -SO 2 N(C alkyl) 2; R 3 is H, or CH 3; alternatively, R 3 and R 2 are taken together with their attached carbon to form R 4 is R 5 is H, or CH 3; alternatively, R 4 and R 5 are taken together with their attached nitrogen to form a ring selected from the group consisting of: R 6 is CF 3, or OCF 3; R 7 is a CF 3 substituted heteroaryl, provided that R 7 is not R x is CF 3, F, Cl, CN, or OCH 3; R y is H, F, Cl, or CF 3; R z is H, or F; or a pharmaceutically acceptable salt thereof, provided that when R 0 and R 1 are taken together with their attached nitrogen to form A is O, or S; R a is phenyl, wherein said phenyl is optionally substituted with C NH 2, C NHCH 3, SO 2 NH 2, C N(CH 3) 2, OCH 3, CO 2 CH 3, or CO 2 H; R 2 is H, C alkyl, cyclopropyl, cyclohexyl, thiazol-2-yl, 1-methyl-imidazol-2-yl, 1-methyl-pyrazol-5-yl, or phenyl; R 4 and R 5 are taken together with their attached nitrogen to form a ring selected from the group consisting of: R 6 is CF 3, or OCF 3; and R 7 is A is O, or S; R 0 is H, or C alkyl; wherein said C alkyl is optionally substituted with OH, C alkyl-(OCH 2 CH 2) n -OCH 3, OCH 3, CO 2 H, C NH 2, SO 2 NH 2, or CO 2 C alkyl; n is 1, 2, or 3; R 1 is cyclohexyl, or tetrahydropyranyl; wherein said cyclohexyl or tetrahydropyranyl may be optionally substituted with one substituent selected from the group consisting of: OCH 3, OH, CH 2 CH 3, -CN, NH 2, NH(CH 3), N(CH 3) 2, or OCF 3; alternatively, R 0 and R 1 are taken together with their attached nitrogen to form a ring selected from the group consisting of R a is phenyl; wherein the phenyl is optionally substituted with C NH 2, C NHC alkyl, SO 2 NH 2, C N(C alkyl) 2, OCH 3, CO 2 CH 3, or CO 2 H; R b is C alkyl, or OC alkyl; R 2 is selected from the group consisting of H, C alkyl, cyclopropyl, cyclohexyl, phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, furyl, and thiophenyl; wherein said phenyl, pyridyl, pyrimidyl, pyrazyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, furyl, or thiophenyl is optionally substituted with one substituent selected from the group consisting of NH 2, NHC alkyl, N(C alkyl) 2, C alkyl, -CN, -CH=CH 2, -CONH 2, -CO 2 H, -NO 2, -CONHC alkyl, CON(C alkyl) 2, C alkylCONH 2, -NHCOC alkyl, -CO 2 C alkyl, CF 3, SO 2 C alkyl, -SO 2 NH 2,-SO 2 NH(C alkyl), and -SO 2 N(C alkyl) 2; R 3 is H, or CH 3; alternatively, R 3 and R 2 are taken together with their attached carbon to form R 4 is R 5 is H, or CH 3; alternatively, R 4 and R 5 are taken together with their attached nitrogen to form a ring selected from the group consisting of: R 6 is CF 3, or OCF 3; R 7 is a CF 3 substituted heteroaryl, provided that R 7 is not R x is CF 3, F, Cl, CN, or OCH 3; R y is H, F, Cl, or CF 3; R z is H, or F; A is O, or S; R a is phenyl, wherein said phenyl is optionally substituted with C NH 2, C NHCH 3, SO 2 NH 2, C N(CH 3) 2, OCH 3, CO 2 CH 3, or CO 2 H; R 2 is H, C alkyl, cyclopropyl, cyclohexyl, thiazol-2-yl, 1-methyl-imidazol-2-yl, 1-methyl-pyrazol-5-yl, or phenyl; R 4 and R 5 are taken together with their attached nitrogen to form a ring selected from the group consisting of: R 6 is CF 3, or OCF 3; and R 7 is