A mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for a bacterial uric acid sensor-regulator fused to a transrepressor domain, wherein the bacterial uric acid sensor-regulator is uricase sensor-regulator HucR from Deinococcus radiodurans R1, the MarR type transcriptional regulator Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, the MarR-type transcriptional regulator Deide_3p00280 from Deinococcus deserti VCD115, or a sensor-regulator derived therefrom, wherein the sensor-regulator derived therefrom contains only conservative amino substitutions and remains at least 90% identical to the said bacterial uric acid sensor-regulator at the amino acid level and includes compounds at the polynucleotide level comprising triplet codons coding for the same amino acid but being especially adapted to mammalian cells; and (b) a vector comprising an operator sequence specifically binding a bacterial uric acid sensor-regulator, a promoter and a polynucleotide coding for a protein, wherein the operator sequence is an operator sequence produced by Deinococcaceae or Pseudomonadaceae specifically binding to sensor-regulator HucR from Deinococcus radiodurans R1, Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, or Deide_3p00280 from Deinococcus deserti VCD115, or an operator sequence derived therefrom, wherein the operator sequence derived therefrom is an operator sequence produced by Deinococcaceae or Pseudomonadaceae specifically binding to sensor-regulator HucR from Deinococcus radiodurans R1, Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, or Deide_3p00280 from Deinococcus deserti VCD115, wherein one to twelve nucleotides of the operator sequence are replaced by other nucleotides without diminishing the intended interaction with the sensor-regulator, wherein the protein is uricase or urate transporter protein. (a) a vector comprising a genetic code for a bacterial uric acid sensor-regulator fused to a transrepressor domain, wherein the bacterial uric acid sensor-regulator is uricase sensor-regulator HucR from Deinococcus radiodurans R1, the MarR type transcriptional regulator Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, the MarR-type transcriptional regulator Deide_3p00280 from Deinococcus deserti VCD115, or a sensor-regulator derived therefrom, wherein the sensor-regulator derived therefrom contains only conservative amino substitutions and remains at least 90% identical to the said bacterial uric acid sensor-regulator at the amino acid level and includes compounds at the polynucleotide level comprising triplet codons coding for the same amino acid but being especially adapted to mammalian cells; and (b) a vector comprising an operator sequence specifically binding a bacterial uric acid sensor-regulator, a promoter and a polynucleotide coding for a protein, wherein the operator sequence is an operator sequence produced by Deinococcaceae or Pseudomonadaceae specifically binding to sensor-regulator HucR from Deinococcus radiodurans R1, Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, or Deide_3p00280 from Deinococcus deserti VCD115, or an operator sequence derived therefrom, wherein the operator sequence derived therefrom is an operator sequence produced by Deinococcaceae or Pseudomonadaceae specifically binding to sensor-regulator HucR from Deinococcus radiodurans R1, Dgeo_2531 from Deinococcus geothermalis DSM 11300, the MarR-type transcriptional regulator from Pseudomonas mendocina ypm, or Deide_3p00280 from Deinococcus deserti VCD115, wherein one to twelve nucleotides of the operator sequence are replaced by other nucleotides without diminishing the intended interaction with the sensor-regulator, wherein the protein is uricase or urate transporter protein.