An isoindoline derivative having a structure of general formula, a pharmaceutically acceptable salt, a solvate, a polymorph, a stereoisomer or an isotopic compound thereof; in the general formula, n1 is 1; Z is wherein the carbon atom labelled by ∗ is an asymmetric center; each of R 1, R 3, R 4, R 5, R 6, R 7, R 8 and R 9 is independently selected from H or D; R 2 is selected from H or D; each of L 1 and L 2 is independently selected from CD 2, CHD or CH 2; X is selected from NH, ND or O; R 10 is wherein each of R 2 ', R 3 ', R 4 'and R 5 ' is independently selected from H, D, a halogen, a cyano, a hydroxy, a substituted or unsubstituted (C 1 -C 12)alkyl, a substituted or unsubstituted (C 1 -C 12)alkoxy, a (C 2 ~C 20)heterocycloalkyl or deuterated (C 2 ~C 20)heterocycloalkyl; wherein each of R a and R b is independently H, a (C 1 -C 12)alkyl, a (C 1 -C 12)alkylacyl; each of R c and R d is independently H or a (C 1 -C 12)alkyl; R e is or a (C 2 ~C 20)heterocycloalkyl; each of R e1 and R e2 is independently H or a (C 1 -C 12)alkyl; the substituent contained in the substituted (C 1 -C 12)alkoxy is selected from the group consisting of D, a halogen, a hydroxy, a (C 1 -C 12)alkoxy, a (C 2 ~C 20)heterocycloalkyl, a (C 2 ~C 20)heteocycloalkyl substitued with a (C 1 -C 12)alkyl, wherein each of R f and R g is independently H or a (C 1 -C 12)alkyl; R h is a (C 2 ~C 20)heterocycloalkyl; the substituent contained in the substituted (C 1 -C 12)alkyl is selected from the group consisting of D, a (C 2~ C 20)heterocycloalkyl, a deuterated (C 2~ C 20)heterocycloalkyl, a (C 2 ~C 20)heteocycloalkyl substituted with a (C 1 -C 12)alkyl, or a (C 2 ~C 20)heteocycloalkyl substituted with a deuterated (C 1 -C 12)alkyl; when more than one substituents are contained in the substituted (C 1 -C 12)alkoxy or the substituted (C 1 -C 12)alkyl, the substituents are the same or different; in each of the groups mentioned above, the heteroatom of the (C 2 ~C 20)heterocycloalkyl contained in the (C 2~ C 20)heterocycloalkyl, the deuterated (C 2~ C 20)heterocycloalkyl, the (C 2 ~C 20)heteocycloalkyl substituted with a (C 1 -C 12)alkyl or the (C 2 ~C 20)heteocycloalkyl substituted with a deuterated (C 1 -C 12)alkyl, is selected from consisting of O, N and S. in the general formula, n1 is 1; Z is wherein the carbon atom labelled by ∗ is an asymmetric center; each of R 1, R 3, R 4, R 5, R 6, R 7, R 8 and R 9 is independently selected from H or D; R 2 is selected from H or D; each of L 1 and L 2 is independently selected from CD 2, CHD or CH 2; X is selected from NH, ND or O; R 10 is wherein each of R 2 ', R 3 ', R 4 'and R 5 ' is independently selected from H, D, a halogen, a cyano, a hydroxy, a substituted or unsubstituted (C 1 -C 12)alkyl, a substituted or unsubstituted (C 1 -C 12)alkoxy, a (C 2 ~C 20)heterocycloalkyl or deuterated (C 2 ~C 20)heterocycloalkyl; wherein each of R a and R b is independently H, a (C 1 -C 12)alkyl, a (C 1 -C 12)alkylacyl; each of R c and R d is independently H or a (C 1 -C 12)alkyl; R e is or a (C 2 ~C 20)heterocycloalkyl; each of R e1 and R e2 is independently H or a (C 1 -C 12)alkyl; the substituent contained in the substituted (C 1 -C 12)alkoxy is selected from the group consisting of D, a halogen, a hydroxy, a (C 1 -C 12)alkoxy, a (C 2 ~C 20)heterocycloalkyl, a (C 2 ~C 20)heteocycloalkyl substitued with a (C 1 -C 12)alkyl, wherein each of R f and R g is independently H or a (C 1 -C 12)alkyl; R h is a (C 2 ~C 20)heterocycloalkyl; the substituent contained in the substituted (C 1 -C 12)alkyl is selected from the group consisting of D, a (C 2~ C 20)heterocycloalkyl, a deuterated (C 2~ C 20)heterocycloalkyl, a (C 2 ~C 20)heteocycloalkyl substituted with a (C 1 -C 12)alkyl, or a (C 2 ~C 20)heteocycloalkyl substituted with a deuterated (C 1 -C 12)alkyl; when more than one substituents are contained in the substituted (C 1 -C 12)alkoxy or the substituted (C 1 -C 12)alkyl, the substituents are the same or different; in each of the groups mentioned above, the heteroatom of the (C 2 ~C 20)heterocycloalkyl contained in the (C 2~ C 20)heterocycloalkyl, the deuterated (C 2~ C 20)heterocycloalkyl, the (C 2 ~C 20)heteocycloalkyl substituted with a (C 1 -C 12)alkyl or the (C 2 ~C 20)heteocycloalkyl substituted with a deuterated (C 1 -C 12)alkyl, is selected from consisting of O, N and S.