A compound expressed by Formula 1, pharmaceutically acceptable salt thereof or optical isomer thereof: where A 1 is -NR 1 R 2; A 2, A 3 and A 4 are, either independently or optionally, any one selected from a group consisting of -H, halogen, - OH, -CN, -N 3, C 1 -C 10 alkoxy, C 1 -C 10 straight- or branched-chain alkyl, C 6 -C 12 aryl, -O (C=O) R 1, - (C=O) R 1, - (C=O) OR 1, - O(C=O) OR 1, -O(C=O) NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O)R 2, - NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3 and -NR 1 (C=S) -NR 2 R 3, or two or more neighboring substituents of A 1, A 2, A 3 and A 4 may form a ring together, wherein a ring formed by two or more neighboring substituents of A 1, A 2, A 3 and A 4 may include one or more hetero atom, and the hetero atom is N, O or S; G is halogen, -OH, -CN, -N 3, C 1 -C 10 alkoxy, -O (C=O) R 1, -(C=O)R 2, -(C=O)OR 1, -O(C=O)OR 1, -O(C=O) NR 1 R 2, -NO 2, -NR 1 R 2, - NR 1 (C=O) R 2, -NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3, - NR 1 (C=S) -NR 2 R 3 or D 1, D 2, D 3 and D 4 are, either independently or optionally, any one selected from a group consisting of -H, halogen, -OH, -CN, C 1 -C 10 alkoxy, C 1 -C 10 straight- or branched-chain alkyl, C 6 -C 12 aryl, -(CH 2) n -(C=O) OR 1, - O (C=O) R 1, - (C=O) R 1, - (C=O) OR 1, -O(C=O) OR 1, -O(C=O)NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O) R 2, -NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) - NR 2 R 3, -SR 1 and -NR 1 (C=S) -NR 2 R 3, or two or more neighboring substituents of D 1, D 2, D 3 and D 4 may for a ring together, a ring formed by two or more neighboring substituent of D 1, D 2, D 3 and D 4 may include one or more hetero atom, and the hetero atom is N, O or S; E is -H, -OH, -OR 1, -O(C=O)R 1, -(C=O)R 1, -(C=O)OR 1, - O(C=O) OR 1, -O (C=O) NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O) R 2, -SR 1, - NR 1 (C=S)R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3 or -NR 1 (C=S) -NR 2 R 3; R 1, R 2 and R 3 are, each independently, hydrogen, non-substituted or phenyl-substituted C 1 -C 10 straight- or branched-chain alkyl, C 1 -C 10 alkoxy, non-substituted or phenyl-substituted C 1 -C 10 straight- or branched-chain alkenyl, C 3 -C 7 cycloalkyl or non-substituted or phenyl-substituted C 6 -C 12 aryl; X and Y are oxygen; Z 1, Z 2 and Z 3 are carbon or nitrogen; n is integer between 1-10; and ' - - - ' denotes a double bond. where A 1 is -NR 1 R 2; A 2, A 3 and A 4 are, either independently or optionally, any one selected from a group consisting of -H, halogen, - OH, -CN, -N 3, C 1 -C 10 alkoxy, C 1 -C 10 straight- or branched-chain alkyl, C 6 -C 12 aryl, -O (C=O) R 1, - (C=O) R 1, - (C=O) OR 1, - O(C=O) OR 1, -O(C=O) NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O)R 2, - NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3 and -NR 1 (C=S) -NR 2 R 3, or two or more neighboring substituents of A 1, A 2, A 3 and A 4 may form a ring together, wherein a ring formed by two or more neighboring substituents of A 1, A 2, A 3 and A 4 may include one or more hetero atom, and the hetero atom is N, O or S; G is halogen, -OH, -CN, -N 3, C 1 -C 10 alkoxy, -O (C=O) R 1, -(C=O)R 2, -(C=O)OR 1, -O(C=O)OR 1, -O(C=O) NR 1 R 2, -NO 2, -NR 1 R 2, - NR 1 (C=O) R 2, -NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3, - NR 1 (C=S) -NR 2 R 3 or D 1, D 2, D 3 and D 4 are, either independently or optionally, any one selected from a group consisting of -H, halogen, -OH, -CN, C 1 -C 10 alkoxy, C 1 -C 10 straight- or branched-chain alkyl, C 6 -C 12 aryl, -(CH 2) n -(C=O) OR 1, - O (C=O) R 1, - (C=O) R 1, - (C=O) OR 1, -O(C=O) OR 1, -O(C=O)NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O) R 2, -NR 1 (C=S) R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) - NR 2 R 3, -SR 1 and -NR 1 (C=S) -NR 2 R 3, or two or more neighboring substituents of D 1, D 2, D 3 and D 4 may for a ring together, a ring formed by two or more neighboring substituent of D 1, D 2, D 3 and D 4 may include one or more hetero atom, and the hetero atom is N, O or S; E is -H, -OH, -OR 1, -O(C=O)R 1, -(C=O)R 1, -(C=O)OR 1, - O(C=O) OR 1, -O (C=O) NR 1 R 2, -NO 2, -NR 1 R 2, -NR 1 (C=O) R 2, -SR 1, - NR 1 (C=S)R 2, -NR 1 (C=O) OR 2, -NR 1 (C=O) -NR 2 R 3 or -NR 1 (C=S) -NR 2 R 3; R 1, R 2 and R 3 are, each independently, hydrogen, non-substituted or phenyl-substituted C 1 -C 10 straight- or branched-chain alkyl, C 1 -C 10 alkoxy, non-substituted or phenyl-substituted C 1 -C 10 straight- or branched-chain alkenyl, C 3 -C 7 cycloalkyl or non-substituted or phenyl-substituted C 6 -C 12 aryl; X and Y are oxygen; Z 1, Z 2 and Z 3 are carbon or nitrogen; n is integer between 1-10; and ' - - - ' denotes a double bond.