mhurhangee/ep-ind-claims huggingface dataset:
A bi-specific asymmetric antibody which in vivo has less susceptibility to undergo exchange than wild type IgG4 antibodies, said antibody comprising: i. two light chains, and ii. two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a C H 1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the C H 1 domain is substituted with a non-thiol containing amino acid; and b. one of the amino acids positioned in the upper hinge region selected from S227, K228, Y229 and G230 is substituted with cysteine, and wherein the second heavy chain or fragment thereof is IgG4 wild type or IgG4 wild type with a S241G or S241A mutation, and wherein each heavy chain has a different variable region. i. two light chains, and ii. two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a C H 1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the C H 1 domain is substituted with a non-thiol containing amino acid; and b. one of the amino acids positioned in the upper hinge region selected from S227, K228, Y229 and G230 is substituted with cysteine, and a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the C H 1 domain is substituted with a non-thiol containing amino acid; and b. one of the amino acids positioned in the upper hinge region selected from S227, K228, Y229 and G230 is substituted with cysteine, and
Process for the preparation of an alkali metal sulfide from at least one oxygen-comprising alkali metal compound, comprising at least one step a) consisting in reacting said oxygen-comprising alkali metal compound(s) with at least one sulfur-comprising compound of formula: in which: - R represents a linear or branched alkyl or linear or branched alkenyl radical comprising from 1 to 6 carbon atoms, preferably from 1 to 4 carbon atoms, limits included; - n is equal to 0, 1 or 2; - x is equal to 0 or to an integer taking the values from 1 to 10, limits included, preferably x is an integer equal to 1, 2, 3 or 4; - R' represents a linear or branched alkyl or a linear or branched alkenyl radical comprising from 1 to 6 carbon atoms, limits included, preferably from 1 to 4 carbon atoms, or, only if n = x = 0, a hydrogen atom; - or else R and R' can together form, with the sulfur-comprising atom(s) which carry/carries them, a sulfur-comprising heterocycle comprising from 2 to 12 carbon atoms, limits included, preferably from 2 to 8 carbon atoms, limits included, and optionally, in addition to the sulfur atom(s) indicated in formula, one or more heteroatoms chosen from oxygen, nitrogen and sulfur, - in which said sulfur-comprising compound of formula is such that n = 0, and - in which said sulfur-comprising compound of formula is such that x = 1, 2 or 3, or is a mixture of sulfur-comprising compounds with, on average, x between 2 and 10 (limits included), preferably with an average value of x of between 3 and 5 (limits included). - R represents a linear or branched alkyl or linear or branched alkenyl radical comprising from 1 to 6 carbon atoms, preferably from 1 to 4 carbon atoms, limits included; - n is equal to 0, 1 or 2; - x is equal to 0 or to an integer taking the values from 1 to 10, limits included, preferably x is an integer equal to 1, 2, 3 or 4; - R' represents a linear or branched alkyl or a linear or branched alkenyl radical comprising from 1 to 6 carbon atoms, limits included, preferably from 1 to 4 carbon atoms, or, only if n = x = 0, a hydrogen atom; - or else R and R' can together form, with the sulfur-comprising atom(s) which carry/carries them, a sulfur-comprising heterocycle comprising from 2 to 12 carbon atoms, limits included, preferably from 2 to 8 carbon atoms, limits included, and optionally, in addition to the sulfur atom(s) indicated in formula, one or more heteroatoms chosen from oxygen, nitrogen and sulfur, - in which said sulfur-comprising compound of formula is such that n = 0, and - in which said sulfur-comprising compound of formula is such that x = 1, 2 or 3, or is a mixture of sulfur-comprising compounds with, on average, x between 2 and 10 (limits included), preferably with an average value of x of between 3 and 5 (limits included).
A method for use in designing a structural health monitoring "SHM" system for use in monitoring a host structure, the SHM system including at least one actuator and at least one sensor, said method comprising: creating a first SHM system model of the SHM system using a finite element model "FEM"; creating a second SHM system model of the SHM system using a FEM, wherein the first model includes structural damage and the second model does not include the structural damage; simulating (308, 310) signal propagation and response of each of the first model and the second model; comparing the simulated responses of the first model and the second model, for a first frequency range comprising a plurality of excitation frequencies, to determine a sensitivity of the SHM system to the structural damage at each of the plurality of excitation frequencies; and storing the simulated responses of each of the first model and the second model; and choosing for use in real world testing, based at least in part on said simulating, a second frequency range within the first frequency range in which the simulated response of the SHM system is most sensitive to the structural damage. creating a first SHM system model of the SHM system using a finite element model "FEM"; creating a second SHM system model of the SHM system using a FEM, wherein the first model includes structural damage and the second model does not include the structural damage; simulating (308, 310) signal propagation and response of each of the first model and the second model; comparing the simulated responses of the first model and the second model, for a first frequency range comprising a plurality of excitation frequencies, to determine a sensitivity of the SHM system to the structural damage at each of the plurality of excitation frequencies; and storing the simulated responses of each of the first model and the second model; and choosing for use in real world testing, based at least in part on said simulating, a second frequency range within the first frequency range in which the simulated response of the SHM system is most sensitive to the structural damage.
A photoresist resin composition, comprising: a plurality of quantum dots; a photopolymerizable monomer; a photopolymerization initiator; a scatterer; a binder resin; and a solvent, wherein an amount of the scatterer is in a range of about 2 parts to about 20 parts by weight based on 100 parts by weight of a total amount of the photoresist resin composition; and characterized in that the photoresist resin composition comprises the quantum dots and the scatterer at a weight ratio in a range of 2:1 to 10:1. a plurality of quantum dots; a photopolymerizable monomer; a photopolymerization initiator; a scatterer; a binder resin; and a solvent, wherein an amount of the scatterer is in a range of about 2 parts to about 20 parts by weight based on 100 parts by weight of a total amount of the photoresist resin composition; and characterized in that the photoresist resin composition comprises the quantum dots and the scatterer at a weight ratio in a range of 2:1 to 10:1.
A water heater for an aircraft beverage brewing apparatus, comprising: a three way electrical conduit for conducting electrical power in three separate phases; a housing coupled to the three way electrical conduit, the housing including a body, a first removable end piece, and a second removable end piece; a fluid inlet port at the first removable end piece and a fluid outlet port at the second removable end piece; a hollow cylindrical core disposed in the housing between the first and second removable end pieces (18, 20), characterized in that the hollow cylindrical core includes a heating element wound around the core from a first end to a second end; and by first, second, and third resettable temperature sensors (24A, 24B, 24C) disposed on the second removable end piece, each of the first, second, and third resettable temperature sensors (24A, 24B, 24C) connected to a separate phase of power from the three way electrical conduit. a three way electrical conduit for conducting electrical power in three separate phases; a housing coupled to the three way electrical conduit, the housing including a body, a first removable end piece, and a second removable end piece; a fluid inlet port at the first removable end piece and a fluid outlet port at the second removable end piece; a hollow cylindrical core disposed in the housing between the first and second removable end pieces (18, 20), characterized in that the hollow cylindrical core includes a heating element wound around the core from a first end to a second end; and by first, second, and third resettable temperature sensors (24A, 24B, 24C) disposed on the second removable end piece, each of the first, second, and third resettable temperature sensors (24A, 24B, 24C) connected to a separate phase of power from the three way electrical conduit.
An endoscopic treatment instrument comprising: a treating portion for carrying out a predetermined treatment with respect to a body; a control rod of flat plate shape with a cross-section having a long axis direction and a short axis direction; and a distal end side connecting member, formed into an oval pipe shape having a constant cross-sectional area and having a proximal opening end surface and a distal opening end surface facing in the axial direction of the control rod, in which a distal end of the control rod and a dissection wire are respectively inserted, and through which the dissection wire and the control rod are connected; wherein the distal end side connecting member has an inlet at its center, through which a solder has been injected, the solder connecting the dissection wire and the control rod by means of soldering, and the proximal opening end surface of said distal end side connecting member is formed with an inclined surface of generally flat shape which intersects the axial direction of the control rod and the short axis direction of the cross-section of the control rod and is parallel with the long axis direction of the cross-section of the control rod. a treating portion for carrying out a predetermined treatment with respect to a body; a control rod of flat plate shape with a cross-section having a long axis direction and a short axis direction; and a distal end side connecting member, formed into an oval pipe shape having a constant cross-sectional area and having a proximal opening end surface and a distal opening end surface facing in the axial direction of the control rod, in which a distal end of the control rod and a dissection wire are respectively inserted, and through which the dissection wire and the control rod are connected; wherein the distal end side connecting member has an inlet at its center, through which a solder has been injected, the solder connecting the dissection wire and the control rod by means of soldering, and the proximal opening end surface of said distal end side connecting member is formed with an inclined surface of generally flat shape which intersects the axial direction of the control rod and the short axis direction of the cross-section of the control rod and is parallel with the long axis direction of the cross-section of the control rod.
Method performed by a mediation function entity for use in a Lawful Intercept system for enabling a Law Enforcement Agency, LEA, to determine targets' positions, said targets are connected to a WiFi network via Access Points, the method comprises steps of: - receiving a RADIUS account message for a subscriber having been accepted access to the WiFi network; - checking by means of a target database if the subscriber is a target, wherein a target is a subscriber of interest for interception; and - based on the checking, performing one of: - if the subscriber is a target, retrieving from the received RADIUS account message RADIUS parameters corresponding to an Access Point Identifier and a Service Set Identifier, SSID, and sending together with a target identification the RADIUS parameters corresponding to the Access Point Identifier and the SSID to the LEA; and - if the subscriber is not a target, discarding the RADIUS account message. - receiving a RADIUS account message for a subscriber having been accepted access to the WiFi network; - checking by means of a target database if the subscriber is a target, wherein a target is a subscriber of interest for interception; and - based on the checking, performing one of: - if the subscriber is a target, retrieving from the received RADIUS account message RADIUS parameters corresponding to an Access Point Identifier and a Service Set Identifier, SSID, and sending together with a target identification the RADIUS parameters corresponding to the Access Point Identifier and the SSID to the LEA; and - if the subscriber is not a target, discarding the RADIUS account message. - if the subscriber is a target, retrieving from the received RADIUS account message RADIUS parameters corresponding to an Access Point Identifier and a Service Set Identifier, SSID, and sending together with a target identification the RADIUS parameters corresponding to the Access Point Identifier and the SSID to the LEA; and - if the subscriber is not a target, discarding the RADIUS account message.
Sieving device with a support device by which a sieve is held, which has at least one sieve lining which is held by a sieve frame which is connected to a drive device, wherein the drive device, which can be controlled by a control unit by means of a control program, comprises at least three actuators (31, 32, 33, 34), characterised in that that the at least three actuators (31, 32, 33, 34) on the one hand are each connected via a first swivel joint (311; 321; 331; 341) to the support device and on the other hand are each connected via a second swivel joint (312; 322; 332; 342) to the sieve frame, so that the sieve is held solely by the actuators (31, 32, 33, 34) and is displaceable and rotatable within an operating volume, and in that the actuators (31, 32, 33, 34) are controllable by the control unit in such a way that they can execute oscillating movements in order to generate vibrations of the sieve lining.
A method for providing a middlebox service for data messages exchanged between machines (122, 132) in each of a plurality of virtual private clouds 'VPCs' (105, 205) in a public cloud, the method comprising: for each of at least two VPCs (105, 205) using a set of one or more middlebox service machines: establishing a logical overlay network on top of an underlay network of the public cloud; configuring at least one logical interface 'LIF' of at least one logical forwarding element 'LFE' of the logical overlay network to direct, to a forwarding element of the underlay network, a subset of data messages with logical destination addresses that are stored in headers of the data messages with a set of other network addresses defined in a logical address space of the logical overlay network, and that identify the destination machines in the VPC (105, 205); and configuring the underlay-network forwarding element to forward data messages received from the LIF to the set of one or more middlebox service machines when the data messages are from the VPC (105, 205) and have destination addresses that fall within at least a subset of addresses in the logical address space, the middlebox service machine set residing outside of the logical overlay network (i) to perform a set of one or more middlebox services on the data messages and (ii) to provide processed data messages to a gateway to forward the data messages to the logical overlay network for forwarding the data messages to destination machines that are addressed by the processed data messages. establishing a logical overlay network on top of an underlay network of the public cloud; configuring at least one logical interface 'LIF' of at least one logical forwarding element 'LFE' of the logical overlay network to direct, to a forwarding element of the underlay network, a subset of data messages with logical destination addresses that are stored in headers of the data messages with a set of other network addresses defined in a logical address space of the logical overlay network, and that identify the destination machines in the VPC (105, 205); and configuring the underlay-network forwarding element to forward data messages received from the LIF to the set of one or more middlebox service machines when the data messages are from the VPC (105, 205) and have destination addresses that fall within at least a subset of addresses in the logical address space, the middlebox service machine set residing outside of the logical overlay network (i) to perform a set of one or more middlebox services on the data messages and (ii) to provide processed data messages to a gateway to forward the data messages to the logical overlay network for forwarding the data messages to destination machines that are addressed by the processed data messages.
An image processing system, wherein the system comprises: an application client, a data source manager, a general-purpose data source, and at least two image input devices corresponding to the general-purpose data source; the general-purpose data source is configured to: switch a mapping relationship between the general-purpose data source and a previously mapped image input device to a mapping relationship between the general-purpose data source and a specified image input device; the application client is configured to send an image processing instruction for the general-purpose data source to the data source manager; the data source manager is configured to: when receiving the image processing instruction, send the image processing instruction to the general-purpose data source; the general-purpose data source is configured to: when receiving the image processing instruction, process, according to the image processing instruction, an image that is obtained by the specified image input device specified by the image processing instruction; and send a processing result to the data source manager; and the data source manager is further configured to: when receiving the processing result, send the processing result to the application client.
A de-stacker for de-stacking a stack of book covers having a backlining and for transferring individual book covers, wherein the de-stacker has a removal unit for removing and holding a top book cover of a stack of book covers and a movement unit for moving the removal unit with the removed and held book cover from the stack of book covers to a transfer point, wherein the removal unit has holding elements for temporarily holding a book cover, characterised in that the removal unit moreover has a holding-down element for holding down the backlining of the book cover, wherein the de-stacker is adapted to hold down the backlining of the top book cover by means of the holding-down element during the removal of the top book cover in order to lift the sides of the top book cover and free them from the stack and, after the sides of the top book cover have been freed, to move the removal unit to the transfer point by means of the movement unit, wherein the holding-down element is resiliently formed by means of a spring, wherein the de-stacker has a sensor for monitoring the holding-down element, wherein the sensor is adapted to measure the preload travel by the spring during the placement on the book cover, wherein the de-stacker is adapted to stop the placement on the book cover after a predetermined travel.
An electronic device, comprising: control circuitry; radio-frequency transceiver circuitry coupled to the control circuitry; a phased antenna array having a plurality of antennas coupled to the radio-frequency transceiver circuitry; and at least one radio-frequency sensor coupled to the control circuitry and having a sensor antenna and a sensor circuit coupled to the sensor antenna that measures radio-frequency signals while the control circuitry uses the radio-frequency transceiver circuitry to transmit wireless radio-frequency signals using at least one of the plurality of antennas, the sensor antenna is not part of the phased antenna array, the sensor antenna of the at least one radio-frequency sensor receives radio-frequency signals and does not transmit any radio-frequency signals, and the control circuitry is configured to take at least one action in response to the measured radio-frequency signals that is selected from the group consisting of: tuning at least one of the plurality of antennas, switching at least one of the plurality of antennas into or out of use, adjusting the phased antenna array, and adjusting a maximum transmit power associated with using the radio-frequency transceiver circuitry to transmit the wireless radio-frequency signals. control circuitry; radio-frequency transceiver circuitry coupled to the control circuitry; a phased antenna array having a plurality of antennas coupled to the radio-frequency transceiver circuitry; and at least one radio-frequency sensor coupled to the control circuitry and having a sensor antenna and a sensor circuit coupled to the sensor antenna that measures radio-frequency signals while the control circuitry uses the radio-frequency transceiver circuitry to transmit wireless radio-frequency signals using at least one of the plurality of antennas, the sensor antenna is not part of the phased antenna array, the sensor antenna of the at least one radio-frequency sensor receives radio-frequency signals and does not transmit any radio-frequency signals, and the control circuitry is configured to take at least one action in response to the measured radio-frequency signals that is selected from the group consisting of: tuning at least one of the plurality of antennas, switching at least one of the plurality of antennas into or out of use, adjusting the phased antenna array, and adjusting a maximum transmit power associated with using the radio-frequency transceiver circuitry to transmit the wireless radio-frequency signals. tuning at least one of the plurality of antennas, switching at least one of the plurality of antennas into or out of use, adjusting the phased antenna array, and adjusting a maximum transmit power associated with using the radio-frequency transceiver circuitry to transmit the wireless radio-frequency signals.