A touch display substrate, comprising a touch substrate, the touch substrate, comprising: a touch structure, comprising a sensor pattern and a touch line, wherein the sensor pattern comprises a plurality of first sensor patterns and a plurality of second sensor patterns, the plurality of first sensor patterns are intersected with and insulated from the plurality of second sensor patterns, and the touch line comprises a plurality of first touch lines and a plurality of second touch lines, each of the plurality of first sensor patterns is connected with at least one of the first touch lines, and each of the plurality of second sensor patterns is connected with at least one of the second touch lines; a first ground line, located at a periphery of the touch structure; and at least one second ground line, located at a side of the first ground line facing away from the touch structure, wherein the touch display substrate further comprises a base substrate and an encapsulation film, wherein the touch structure, the first ground line, and the at least one second ground line are located at a side of the encapsulation film facing away from the base substrate, the encapsulation film comprises a first film, a second film, and a third film, the second film is located between the first film and the third film, and the first film and the third film are in contact with each other at an edge to form a contacting part, and characterized in that: an orthographic projection of the at least one second ground line on the base substrate falls within an orthographic projection of the contacting part on the base substrate, or an orthographic projection of the at least one second ground line on the base substrate falls within an orthographic projection of the second film on the base substrate. a touch structure, comprising a sensor pattern and a touch line, wherein the sensor pattern comprises a plurality of first sensor patterns and a plurality of second sensor patterns, the plurality of first sensor patterns are intersected with and insulated from the plurality of second sensor patterns, and the touch line comprises a plurality of first touch lines and a plurality of second touch lines, each of the plurality of first sensor patterns is connected with at least one of the first touch lines, and each of the plurality of second sensor patterns is connected with at least one of the second touch lines; a first ground line, located at a periphery of the touch structure; and at least one second ground line, located at a side of the first ground line facing away from the touch structure, wherein the touch display substrate further comprises a base substrate and an encapsulation film, wherein the touch structure, the first ground line, and the at least one second ground line are located at a side of the encapsulation film facing away from the base substrate, the encapsulation film comprises a first film, a second film, and a third film, the second film is located between the first film and the third film, and the first film and the third film are in contact with each other at an edge to form a contacting part, and characterized in that: an orthographic projection of the at least one second ground line on the base substrate falls within an orthographic projection of the contacting part on the base substrate, or an orthographic projection of the at least one second ground line on the base substrate falls within an orthographic projection of the second film on the base substrate.