A compound of formula Ib wherein Z is independently selected from N and CH; R 1 is independently selected from H, halogen, OH, CONHR 2, CON(R 2) 2, CF 3, R 2 OR 2, CN, morpholino, thiomorpholinyl, thiomorpholino-1, 1-dioxide, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, imidazolyl, substituted or unsubstituted pyrrolidinyl and C 1-4 alkylene wherein the carbon atoms are optionally replaced with NR Y and/or O substituted with morpholino, thiomorpholinyl, thiomorpholino-1, 1-dioxide, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, imidazolyl or substituted or unsubstituted pyrrolidinyl; R 2 is substituted or unsubstituted C 1-4 alkyl; R Y is H or substituted or unsubstituted C 1-4 alkyl; R 8 is R X CN; R X is substituted or unsubstituted C 1-4 alkylene wherein up to 2 carbon atoms can be optionally replaced with CO, NS 2 R, NR Y, CONR Y, SO, SO 2 or O; R 11 is H or C 1-4 alkyl, wherein the substituents are selected from the group consisting of C 1-4 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, heterocyclyl, halo, haloaryl, haloheterocyclyl, hydroxy, C 1-4 alkoxy, aryloxy, carboxy, amino, C 1-6 alkylacyl, arylacyl, heterocyclylacyl, acylamino, acyloxy, C 1-6 alkylsulphenyl, arylsulphonyl and cyano; or an enantiomer thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof, wherein the prodrugs are selected from • compounds wherein an amino acid residue, or a polypeptide chain of two or more amino acid residues is covalently joined through a peptide bond to a free amino, hydroxy or carboxylic acid group of said compound of formula Ib; • compounds wherein a carbonate, carbamate, amide or alkyl ester is covalently bonded to a free amino, amido, hydroxy or carboxylic acid group of said compound of formula Ib through a carbonyl carbon prodrug sidechain; and • compounds wherein a free hydroxyl of said compound of formula Ib is joined through a phosphorus-oxygen bond to a phosphate derivative of a compound (such as an acid, salt of acid, or ester). Z is independently selected from N and CH; R 1 is independently selected from H, halogen, OH, CONHR 2, CON(R 2) 2, CF 3, R 2 OR 2, CN, morpholino, thiomorpholinyl, thiomorpholino-1, 1-dioxide, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, imidazolyl, substituted or unsubstituted pyrrolidinyl and C 1-4 alkylene wherein the carbon atoms are optionally replaced with NR Y and/or O substituted with morpholino, thiomorpholinyl, thiomorpholino-1, 1-dioxide, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, imidazolyl or substituted or unsubstituted pyrrolidinyl; R 2 is substituted or unsubstituted C 1-4 alkyl; R Y is H or substituted or unsubstituted C 1-4 alkyl; R 8 is R X CN; R X is substituted or unsubstituted C 1-4 alkylene wherein up to 2 carbon atoms can be optionally replaced with CO, NS 2 R, NR Y, CONR Y, SO, SO 2 or O; R 11 is H or C 1-4 alkyl, wherein the substituents are selected from the group consisting of C 1-4 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, heterocyclyl, halo, haloaryl, haloheterocyclyl, hydroxy, C 1-4 alkoxy, aryloxy, carboxy, amino, C 1-6 alkylacyl, arylacyl, heterocyclylacyl, acylamino, acyloxy, C 1-6 alkylsulphenyl, arylsulphonyl and cyano; • compounds wherein an amino acid residue, or a polypeptide chain of two or more amino acid residues is covalently joined through a peptide bond to a free amino, hydroxy or carboxylic acid group of said compound of formula Ib; • compounds wherein a carbonate, carbamate, amide or alkyl ester is covalently bonded to a free amino, amido, hydroxy or carboxylic acid group of said compound of formula Ib through a carbonyl carbon prodrug sidechain; and • compounds wherein a free hydroxyl of said compound of formula Ib is joined through a phosphorus-oxygen bond to a phosphate derivative of a compound (such as an acid, salt of acid, or ester).