A compound of Formula: or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof, wherein: G 1 and G 2 are each independently a bond, C 2 -C 12 alkylene, or C 2 -C 12 alkenylene, wherein one or more -CH 2 - in the alkylene or alkenylene is optionally replaced by -O-; L 1 is -OC(=O)R 1, -C(=O)OR 1, -OC(=O)OR 1, -C(=O)R 1, -OR 1, -S x R 1, -S-SR 1, - C(=O)SR 1, -SC(=O)R 1, -NR a C(=O)R 1, -C(=O)NR b R c, -NR a C(=O)NR b R c, -OC(=O)NR b R c, - NR a C(=O)OR 1, -SC(=S)R 1, -C(=S)SR 1, -C(=S)R 1, -CH R 1, -P(=O)(OR b)(OR c), -(C 6 -C 10 arylene)-R 1, -(6- to 10-membered heteroarylene)-R 1, or R 1; L 2 is -OC(=O)R 2, -C(=O)OR 2, -OC(=O)OR 2, -C(=O)R 2, -OR 2, -S x R 2, -S-SR 2, - C(=O)SR 2, -SC(=O)R 2, -NR d C(=O)R 2, -C(=O)NR e R f, -NR d C(=O)NR e R f, -OC(=O)NR e R f, - NR d C(=O)OR 2, -SC(=S)R 2, -C(=S)SR 2, -C(=S)R 2, -CH R 2, -P(=O)(OR e)(OR f), -(C 6 -C 10 arylene)-R 2, -(6- to 10-membered heteroarylene)-R 2, or R 2; R 1 and R 2 are each independently C 6 -C 32 alkyl or C 6 -C 32 alkenyl; R a, R b, R d, and R e are each independently H, C 1 -C 24 alkyl, or C 2 -C 24 alkenyl; R c and R f are each independently C 1 -C 32 alkyl or C 2 -C 32 alkenyl; G 3 is C 2 -C 24 alkylene, C 2 -C 24 alkenylene, C 3 -C 8 cycloalkylene, or C 3 -C 8 cycloalkenylene; R 3 is -N(R 4)R 5; R 4 is C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, or 4- to 8-membered heterocyclyl; and R 4 is unsubstituted or substituted with one or more hydroxyl, halogen, C 1 -C 6 alkyl, or oxo; R 5 is C 1 -C 12 alkyl or C 3 -C 8 cycloalkyl; and R 5 is unsubstituted, substituted with one or more hydroxyl, or substituted with one or more hydroxyl and one or more oxo; x is 0, 1 or 2; and wherein each alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, alkylene, alkenylene, cycloalkylene, cycloalkenylene, arylene, and heteroarylene is independently optionally substituted, wherein prodrug is acetate, formate and benzoate derivatives of alcohol or amide derivatives of amine functional groups of said compound of Formula. G 1 and G 2 are each independently a bond, C 2 -C 12 alkylene, or C 2 -C 12 alkenylene, wherein one or more -CH 2 - in the alkylene or alkenylene is optionally replaced by -O-; L 1 is -OC(=O)R 1, -C(=O)OR 1, -OC(=O)OR 1, -C(=O)R 1, -OR 1, -S x R 1, -S-SR 1, - C(=O)SR 1, -SC(=O)R 1, -NR a C(=O)R 1, -C(=O)NR b R c, -NR a C(=O)NR b R c, -OC(=O)NR b R c, - NR a C(=O)OR 1, -SC(=S)R 1, -C(=S)SR 1, -C(=S)R 1, -CH R 1, -P(=O)(OR b)(OR c), -(C 6 -C 10 arylene)-R 1, -(6- to 10-membered heteroarylene)-R 1, or R 1; L 2 is -OC(=O)R 2, -C(=O)OR 2, -OC(=O)OR 2, -C(=O)R 2, -OR 2, -S x R 2, -S-SR 2, - C(=O)SR 2, -SC(=O)R 2, -NR d C(=O)R 2, -C(=O)NR e R f, -NR d C(=O)NR e R f, -OC(=O)NR e R f, - NR d C(=O)OR 2, -SC(=S)R 2, -C(=S)SR 2, -C(=S)R 2, -CH R 2, -P(=O)(OR e)(OR f), -(C 6 -C 10 arylene)-R 2, -(6- to 10-membered heteroarylene)-R 2, or R 2; R 1 and R 2 are each independently C 6 -C 32 alkyl or C 6 -C 32 alkenyl; R a, R b, R d, and R e are each independently H, C 1 -C 24 alkyl, or C 2 -C 24 alkenyl; R c and R f are each independently C 1 -C 32 alkyl or C 2 -C 32 alkenyl; G 3 is C 2 -C 24 alkylene, C 2 -C 24 alkenylene, C 3 -C 8 cycloalkylene, or C 3 -C 8 cycloalkenylene; R 3 is -N(R 4)R 5; R 4 is C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, or 4- to 8-membered heterocyclyl; and R 4 is unsubstituted or substituted with one or more hydroxyl, halogen, C 1 -C 6 alkyl, or oxo; R 5 is C 1 -C 12 alkyl or C 3 -C 8 cycloalkyl; and R 5 is unsubstituted, substituted with one or more hydroxyl, or substituted with one or more hydroxyl and one or more oxo; x is 0, 1 or 2; and wherein each alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, alkylene, alkenylene, cycloalkylene, cycloalkenylene, arylene, and heteroarylene is independently optionally substituted, wherein prodrug is acetate, formate and benzoate derivatives of alcohol or amide derivatives of amine functional groups of said compound of Formula.