mhurhangee/ep-ind-claims huggingface dataset:
A compound according to Formula Ib: wherein X is O or S; R 1 is H; or R 1 is selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, and C 1 -C 6 acyl; each of which may optionally be substituted with cyano, one or more halo, hydroxyl, or C 1 -C 6 alkoxy; R 2a is selected from H, P 2, and C (CH 2) n1 C OH; or R 2a is selected from C 1 -C 6 acyl, and C 3 -C 6 alkenyl; each of which may optionally be substituted with amino, or carboxy; n1 is 0, 1, 2, 3, or 4; each R 2b and R 2c is independently selected from H, and C 1 -C 6 alkyl; or R 2b and R 2c may join together to form a C 3 -C 7 cycloalkyl; R 3a is H, halo, cyano, or nitro; each R 3b is independently halo, cyano, or nitro; each R 4a, and R 4b is independently H, halo, cyano, carboxy or nitro; or each R 4a, and R 4b is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; each of which may optionally be substituted by one or more halo, or C 1 -C 6 alkoxy; or R 4a and R 4b are joined together to form an 5 or 6- membered cycloalkyl, 5 or 6-membered heterocycloalkyl, 5 or 6-membered aryl, or 5 or 6-membered heteroaryl; R 4c is halo, cyano, or nitro; and ml is 0, 1, or 2; or pharmaceutically acceptable salts, and the solvates of the compounds or the solvates of the pharmaceutically acceptable salts thereof. X is O or S; R 1 is H; or R 1 is selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, and C 1 -C 6 acyl; each of which may optionally be substituted with cyano, one or more halo, hydroxyl, or C 1 -C 6 alkoxy; R 2a is selected from H, P 2, and C (CH 2) n1 C OH; or R 2a is selected from C 1 -C 6 acyl, and C 3 -C 6 alkenyl; each of which may optionally be substituted with amino, or carboxy; n1 is 0, 1, 2, 3, or 4; each R 2b and R 2c is independently selected from H, and C 1 -C 6 alkyl; or R 2b and R 2c may join together to form a C 3 -C 7 cycloalkyl; R 3a is H, halo, cyano, or nitro; each R 3b is independently halo, cyano, or nitro; each R 4a, and R 4b is independently H, halo, cyano, carboxy or nitro; or each R 4a, and R 4b is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; each of which may optionally be substituted by one or more halo, or C 1 -C 6 alkoxy; or R 4a and R 4b are joined together to form an 5 or 6- membered cycloalkyl, 5 or 6-membered heterocycloalkyl, 5 or 6-membered aryl, or 5 or 6-membered heteroaryl; R 4c is halo, cyano, or nitro; and ml is 0, 1, or 2;
Laser working machine for laser working of tubes and profiled sections, comprising a working head provided with a focussing device arranged to emit a focussed laser beam on a surface of the tube or profiled section to be worked, a carriage on which the working head is mounted, wherein the carriage is mounted so as to be able to translate relative to the tube or profiled section both in a longitudinal direction (x) coinciding with the longitudinal axis of the tube and in a transverse direction (y). characterised by a scanning system arranged to scan at least a portion of the outline of the cross-section of the tube or profiled section, wherein the scanning system comprises at least one laser scanning module having a laser emitter arranged to emit a light blade with which to illuminate a portion of the tube or profiled section, a camera arranged to acquire an image of the portion of tube or profiled section illuminated by said light blade, and a processing unit configured to process the images acquired by each camera to reconstruct the whole outline, or at least a portion thereof, of the cross-section of the tube or profiled section, and wherein the working head and said at least one laser scanning module are mounted on said carriage so as to be drivingly connected for translation therewith both in the longitudinal direction (x) and in the transverse direction (y).
A method of orienting, processing, embedding and microtome slicing a tissue sample using a gel compound block preformed into a self supporting geometric shape, the method comprising: retaining the tissue sample in an orientation in a hole, slit or groove formed in the preformed, geometrically shaped gel compound block, and between resiliently deformable first and second portions (20, 22) of the same preformed, geometrically shaped gel compound block, the first and second resiliently deformable portions applying a force to the tissue sample to thereby retain the tissue sample; processing the tissue sample while in the orientation by subjecting the tissue sample and the preformed, geometrically shaped gel compound block to processing fluids and reagents; securing the preformed, geometrically shaped gel compound block and the retained tissue sample on a microtome sectionable cassette; embedding the preformed, geometrically shaped gel compound block, the microtome sectionable cassette and the tissue sample while in the orientation in an embedding media to form a microtome sectionable block of the embedding media, the tissue sample, the microtome sectionable cassette and the preformed, geometrically shaped gel compound block; and microtome sectioning the microtome sectionable block to obtain thin sections of the tissue sample for diagnosis. retaining the tissue sample in an orientation in a hole, slit or groove formed in the preformed, geometrically shaped gel compound block, and between resiliently deformable first and second portions (20, 22) of the same preformed, geometrically shaped gel compound block, the first and second resiliently deformable portions applying a force to the tissue sample to thereby retain the tissue sample; processing the tissue sample while in the orientation by subjecting the tissue sample and the preformed, geometrically shaped gel compound block to processing fluids and reagents; securing the preformed, geometrically shaped gel compound block and the retained tissue sample on a microtome sectionable cassette; embedding the preformed, geometrically shaped gel compound block, the microtome sectionable cassette and the tissue sample while in the orientation in an embedding media to form a microtome sectionable block of the embedding media, the tissue sample, the microtome sectionable cassette and the preformed, geometrically shaped gel compound block; and microtome sectioning the microtome sectionable block to obtain thin sections of the tissue sample for diagnosis.
A manifold for a medicament delivery device configured to deliver discrete doses of medicament contained in a plurality of individual compartments spaced along a carrier strip and sealed by a sealing layer to form a medicament carrier, the manifold comprising: at least one opening mechanism comprising a release member arranged to engage between the carrier strip and the sealing layer of a medicament carrier so as to separate the sealing layer from the carrier strip and thereby open a compartment of the medicament carrier as it is advanced into an entrainment position; wherein the release member includes a surface configured to cover the opened compartment when in the entrainment position so as substantially to contain the medicament dose of said opened compartment; wherein the opening mechanism further comprises a cylindrical indexing wheel having a plurality of indentations spaced around its exterior surface, each indentation configured to receive a compartment of the medicament carrier therein such that rotation of the indexing wheel advances the medicament carrier and thereby moves compartments of the medicament carrier sequentially into the entrainment position; wherein the indexing wheel is positioned adjacent said surface of the release member such that the separated carrier strip passes between the indexing wheel and the release member; and wherein, while in the entrainment position, the opened compartment is retained within the indentation of the indexing wheel into which it is received, whereby subsequent rotation of the indexing wheel allows the compartment to be released from said indent. at least one opening mechanism comprising a release member arranged to engage between the carrier strip and the sealing layer of a medicament carrier so as to separate the sealing layer from the carrier strip and thereby open a compartment of the medicament carrier as it is advanced into an entrainment position; wherein the release member includes a surface configured to cover the opened compartment when in the entrainment position so as substantially to contain the medicament dose of said opened compartment; wherein the opening mechanism further comprises a cylindrical indexing wheel having a plurality of indentations spaced around its exterior surface, each indentation configured to receive a compartment of the medicament carrier therein such that rotation of the indexing wheel advances the medicament carrier and thereby moves compartments of the medicament carrier sequentially into the entrainment position; wherein the indexing wheel is positioned adjacent said surface of the release member such that the separated carrier strip passes between the indexing wheel and the release member; and wherein, while in the entrainment position, the opened compartment is retained within the indentation of the indexing wheel into which it is received, whereby subsequent rotation of the indexing wheel allows the compartment to be released from said indent.
A pharmaceutical or dermatological composition for application thereof as a medicament for the treatment of tissue lesions selected from the group comprising locomotor system lesions, bone marrow lesions, muscular tissue lesions, lung lesions, skin lesions, digestive tract lesions, said composition comprising: - a biocompatible polymer of general formula AaXxYy or of formula: AaXxYyZz in which: A represents a monomer which is glucose X represents an R 1 COOR 2 group, Y represents a R 7 SO 3 R 8 group Z is an acid acetic group R 1 represents an aliphatic hydrocarbon-based chain which is optionally branched and/or unsaturated, R 2, represents a hydrogen atom or a cation, Rs is an alkali metal selected from the group comprising lithium, sodium, potassium, rubidium and cesium, and R 7 is a bound, a represents the number of monomers such as the weight of said polymers of formula is greater than 2000 daltons, x represents the degree of substitution of the monomers A by groups X, x is between 20% and 150%. y represents the degree of substitution of the monomers A by groups Y, y is between 30% and 150%, z represents the degree of substitution of the monomers A by groups Z, z is from 0% to 50%, preferably equal to 30%. and - a eukaryotic cell selected from mesenchymal cells, adipocytes cells, bone marrow cells. - a biocompatible polymer of general formula AaXxYy or of formula: AaXxYyZz in which: A represents a monomer which is glucose X represents an R 1 COOR 2 group, Y represents a R 7 SO 3 R 8 group Z is an acid acetic group R 1 represents an aliphatic hydrocarbon-based chain which is optionally branched and/or unsaturated, R 2, represents a hydrogen atom or a cation, Rs is an alkali metal selected from the group comprising lithium, sodium, potassium, rubidium and cesium, and R 7 is a bound, a represents the number of monomers such as the weight of said polymers of formula is greater than 2000 daltons, x represents the degree of substitution of the monomers A by groups X, x is between 20% and 150%. y represents the degree of substitution of the monomers A by groups Y, y is between 30% and 150%, z represents the degree of substitution of the monomers A by groups Z, z is from 0% to 50%, preferably equal to 30%. and A represents a monomer which is glucose X represents an R 1 COOR 2 group, Y represents a R 7 SO 3 R 8 group Z is an acid acetic group R 1 represents an aliphatic hydrocarbon-based chain which is optionally branched and/or unsaturated, R 2, represents a hydrogen atom or a cation, Rs is an alkali metal selected from the group comprising lithium, sodium, potassium, rubidium and cesium, and R 7 is a bound, a represents the number of monomers such as the weight of said polymers of formula is greater than 2000 daltons, x represents the degree of substitution of the monomers A by groups X, x is between 20% and 150%. y represents the degree of substitution of the monomers A by groups Y, y is between 30% and 150%, z represents the degree of substitution of the monomers A by groups Z, z is from 0% to 50%, preferably equal to 30%. - a eukaryotic cell selected from mesenchymal cells, adipocytes cells, bone marrow cells.
A medical balloon assembly, comprising: a catheter having a proximal and distal end, a balloon having two opposed shoulder portions terminating into first and second legs, wherein the balloon is configured to be arranged over a portion of the distal end of the catheter; and a continuous fiber extending from the first leg at a first position to a second leg at a second position the fiber being at least partially wrapped around the second leg at the second position and returning back to the first leg portion at a third position, wherein the first and third positions are different. a catheter having a proximal and distal end, a balloon having two opposed shoulder portions terminating into first and second legs, wherein the balloon is configured to be arranged over a portion of the distal end of the catheter; and a continuous fiber extending from the first leg at a first position to a second leg at a second position the fiber being at least partially wrapped around the second leg at the second position and returning back to the first leg portion at a third position, wherein the first and third positions are different.
A data system, comprising: an information bus; a volatile memory located on the information bus; a Magnetic Random Access Memory, MRAM, 136 located on the information bus; a threat handling circuit, wherein in response to a first threat condition, the threat handling circuit initiates a transfer of data via the information bus from the MRAM to the volatile memory for storage during a threat to the MRAM as indicated by the first threat condition, and wherein the threat is characterized by a magnetic field exposure. an information bus; a volatile memory located on the information bus; a Magnetic Random Access Memory, MRAM, 136 located on the information bus; a threat handling circuit, wherein in response to a first threat condition, the threat handling circuit initiates a transfer of data via the information bus from the MRAM to the volatile memory for storage during a threat to the MRAM as indicated by the first threat condition, and wherein the threat is characterized by a magnetic field exposure.
A method for automatically processing patient sample material within a sample processing station, said method comprising: (a) providing to the sample processing station, a sample container (102, 210, 211) containing a volume of patient sample material, the sample container including a sample container barcode on a surface thereof, the sample container barcode containing patient identifying information; (b) with a barcode reader, reading the sample container barcode on the sample container in the sample processing station; (c) providing a tubular reaction vessel to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel; (d) with the printer module, printing a barcode on the surface of the reaction vessel by direct thermal printing or thermal transfer printing, the barcode printed onto the reaction vessel being associated with the sample container barcode read in step (b); and (e) automatically moving the reaction vessel from the printer module to the sample processing station. (a) providing to the sample processing station, a sample container (102, 210, 211) containing a volume of patient sample material, the sample container including a sample container barcode on a surface thereof, the sample container barcode containing patient identifying information; (b) with a barcode reader, reading the sample container barcode on the sample container in the sample processing station; (c) providing a tubular reaction vessel to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel; (d) with the printer module, printing a barcode on the surface of the reaction vessel by direct thermal printing or thermal transfer printing, the barcode printed onto the reaction vessel being associated with the sample container barcode read in step (b); and (e) automatically moving the reaction vessel from the printer module to the sample processing station.
A method relating to a time when a wireless terminal (22, 36) reports an event to a network (14, 32), the method implemented in the wireless terminal comprising: detecting an event to be reported to the network, determining a rate of change of a received signal parameter for a signal received from a base station currently serving the wireless terminal. characterized by calculating a time when a call may drop as a function of received signal parameter value at that moment, a minimum received signal parameter value, and the determined rate of change, wherein the minimum received signal parameter value is the value required for the call not to drop, comparing the calculated time when the call may drop to a total delay budget, wherein the total delay budget is the sum of a time-to-trigger-period, a network processing delay, and a round trip time, determining a communications condition affecting a communication between the wireless terminal and the network, wherein the communications condition is that the time when the call may drop is shorter than the total delay budget, and adjusting the time-to-trigger period based on the detected communications condition so that a physical channel reconfiguration message arrives at the UE before the call drops. detecting an event to be reported to the network, determining a rate of change of a received signal parameter for a signal received from a base station currently serving the wireless terminal. characterized by calculating a time when a call may drop as a function of received signal parameter value at that moment, a minimum received signal parameter value, and the determined rate of change, wherein the minimum received signal parameter value is the value required for the call not to drop, comparing the calculated time when the call may drop to a total delay budget, wherein the total delay budget is the sum of a time-to-trigger-period, a network processing delay, and a round trip time, determining a communications condition affecting a communication between the wireless terminal and the network, wherein the communications condition is that the time when the call may drop is shorter than the total delay budget, and adjusting the time-to-trigger period based on the detected communications condition so that a physical channel reconfiguration message arrives at the UE before the call drops.
A method for manufacturing a nonwoven fabric having an air permeability of between 100 and 1500 l/m 2 /s when measured at a pressure difference of 200 Pa according to EN ISO 9237, the method comprising the steps of: providing at least two sets of fibers, wherein a first fiber set comprises a significant level of at least 30 wt-% of splittable fibers and a second fiber set comprises a low level of less than 20 wt-% of splittable fibers or no splittable fibers; using the first fiber set to form at least one first fibrous web in a first web formation process and using the second fiber set to form at least one second fibrous web in a second web formation process; stacking the first and second webs so obtained to provide a multilayer web including two distinct layers of fibrous webs; bonding the multilayer web, wherein the bonding comprises spunlacing to direct high pressure fluid jets to the multilayer web; and impregnating the bonded multilayer web, the impregnating comprising adding a binder to stiffen and fixate the nonwoven fabric and a flame retardant. providing at least two sets of fibers, wherein a first fiber set comprises a significant level of at least 30 wt-% of splittable fibers and a second fiber set comprises a low level of less than 20 wt-% of splittable fibers or no splittable fibers; using the first fiber set to form at least one first fibrous web in a first web formation process and using the second fiber set to form at least one second fibrous web in a second web formation process; stacking the first and second webs so obtained to provide a multilayer web including two distinct layers of fibrous webs; bonding the multilayer web, wherein the bonding comprises spunlacing to direct high pressure fluid jets to the multilayer web; and impregnating the bonded multilayer web, the impregnating comprising adding a binder to stiffen and fixate the nonwoven fabric and a flame retardant.
Method for synthesizing an N -alkyl-glycosyl(di)amine derivative represented by the following general formula: wherein: - R 1 is a glycosyl radical chosen from a rhamnosyl, glucosyl, galactosyl, maltosyl, lactosyl radical, - R 2 represents a hydrogen atom, - n is an integer ranging from 0 to 20, - X represents an alkyl, alkenyl, alkynyl radical, or an -NR 3 R 4 group, wherein R 3 represents a hydrogen atom or a glycosyl radical chosen from a rhamnosyl, glucosyl, galactosyl, maltosyl, lactosyl radical, and R 4 represents a hydrogen atom or a C 1 -C 12 alkyl radical, with the condition that n is different from 0 when X is an -NR 3 R 4 group, said method comprising the following steps: (i) mixing in a reactor of an ose or oside compound chosen from rhamnose, glucose, galactose, maltose, lactose and an amine of formula R 2 NH-(CH 2) n -X, and (ii) grinding said mixture in a ball mill. - R 1 is a glycosyl radical chosen from a rhamnosyl, glucosyl, galactosyl, maltosyl, lactosyl radical, - R 2 represents a hydrogen atom, - n is an integer ranging from 0 to 20, - X represents an alkyl, alkenyl, alkynyl radical, or an -NR 3 R 4 group, wherein R 3 represents a hydrogen atom or a glycosyl radical chosen from a rhamnosyl, glucosyl, galactosyl, maltosyl, lactosyl radical, and R 4 represents a hydrogen atom or a C 1 -C 12 alkyl radical, (i) mixing in a reactor of an ose or oside compound chosen from rhamnose, glucose, galactose, maltose, lactose and an amine of formula R 2 NH-(CH 2) n -X, and (ii) grinding said mixture in a ball mill.