An endoscope comprising: an insertion portion insertable into a subject and comprising a bending portion bendable in all directions including four directions of up, down, left and right directions with a longitudinal insertion axis as a center; four wires configured to cause the bending portion to bend by pulling, distal end sides of the four wires being inserted through the insertion portion; an operation portion linked to a proximal end of the insertion portion; an operation button projectingly disposed at the center in a left and right width direction of the operation portion; a button linking member provided in the operation portion and linked to the operation button; an operation lever disposed at the center in the left and right width direction of the operation portion so that the operation lever and the operation button face each other in front and behind, and tiltable in all directions including four directions corresponding to the up, down, left and right directions of the bending portion; and a wire pulling member tiltably provided in the operation portion, the operation lever being coupled with a central part of the wire pulling member, and proximal end sides of the wires being coupled with respective distal end sides of four arm portions extended in cross directions from the central part; wherein tilt directions of the operation lever for causing the bending portion to bend in the up, down, left and right directions are set to correspond to four directions of the left and right width directions of the operation portion and directions orthogonal to the left and right width directions, respectively; characterized in that the four arm portions of the wire pulling member are disposed at positions rotated around a longitudinal central axis of the operation lever by a predetermined angle within a range of 30 to 60 degrees relative to the four tilt directions set for the operation lever; and the button linking member is provided at a position facing the wire pulling member and is positioned between and faced by two arm portions among the four arm portions so that, when the operation lever is tilted, the four arm portions and the four wires, coupled with respective distal end sides of the four arm portions do not interfere with the button linking member. an insertion portion insertable into a subject and comprising a bending portion bendable in all directions including four directions of up, down, left and right directions with a longitudinal insertion axis as a center; four wires configured to cause the bending portion to bend by pulling, distal end sides of the four wires being inserted through the insertion portion; an operation portion linked to a proximal end of the insertion portion; an operation button projectingly disposed at the center in a left and right width direction of the operation portion; a button linking member provided in the operation portion and linked to the operation button; an operation lever disposed at the center in the left and right width direction of the operation portion so that the operation lever and the operation button face each other in front and behind, and tiltable in all directions including four directions corresponding to the up, down, left and right directions of the bending portion; and a wire pulling member tiltably provided in the operation portion, the operation lever being coupled with a central part of the wire pulling member, and proximal end sides of the wires being coupled with respective distal end sides of four arm portions extended in cross directions from the central part; wherein tilt directions of the operation lever for causing the bending portion to bend in the up, down, left and right directions are set to correspond to four directions of the left and right width directions of the operation portion and directions orthogonal to the left and right width directions, respectively; characterized in that the four arm portions of the wire pulling member are disposed at positions rotated around a longitudinal central axis of the operation lever by a predetermined angle within a range of 30 to 60 degrees relative to the four tilt directions set for the operation lever; and the button linking member is provided at a position facing the wire pulling member and is positioned between and faced by two arm portions among the four arm portions so that, when the operation lever is tilted, the four arm portions and the four wires, coupled with respective distal end sides of the four arm portions do not interfere with the button linking member.