A fiber optic splice enclosure system comprising: an enclosure defining an enclosure chamber; first and second endplate assemblies (100, 200) adapted to be interchangeably mounted on the enclosure to provide different respective configurations for connecting drop fiber optic cables to the enclosure; wherein the first endplate assembly includes cable pass through ports each configured to terminate a drop fiber optic cable by the drop fiber optic cable passing and extending through the cable pass through port into the enclosure chamber and an optical fiber of the drop fiber optic cable being spliced within the enclosure chamber; and the second endplate assembly includes optical fiber connectors each configured to terminate a drop fiber optic cable by an optical fiber of the drop fiber optic cable being terminated to the optical fiber connector; wherein the first and second endplate assemblies (100, 200) are each configured to connect the drop fiber optic cables to the enclosure; and the enclosure further includes resilient grommets mounted in cable slots defined by a base to form an environmental seal about a main fiber optic cable, the resilient grommets each include a main port and a side opening formed by a radially and longitudinally extending slit the main port configured to receive the main fiber optic cable into the enclosure chamber; wherein the radially and longitudinally extending slit enables a section of the main fiber optic cable to be inserted laterally into the main port, and each of the first and second endplate assemblies (100, 200) when mounted on the enclosure, closes the side opening of the main port to prevent lateral removal of the main fiber optic cable from the main port; and wherein a splice tray is disposed in the enclosure chamber. an enclosure defining an enclosure chamber; first and second endplate assemblies (100, 200) adapted to be interchangeably mounted on the enclosure to provide different respective configurations for connecting drop fiber optic cables to the enclosure; wherein the first endplate assembly includes cable pass through ports each configured to terminate a drop fiber optic cable by the drop fiber optic cable passing and extending through the cable pass through port into the enclosure chamber and an optical fiber of the drop fiber optic cable being spliced within the enclosure chamber; and the second endplate assembly includes optical fiber connectors each configured to terminate a drop fiber optic cable by an optical fiber of the drop fiber optic cable being terminated to the optical fiber connector; wherein the first and second endplate assemblies (100, 200) are each configured to connect the drop fiber optic cables to the enclosure; and the enclosure further includes resilient grommets mounted in cable slots defined by a base to form an environmental seal about a main fiber optic cable, the resilient grommets each include a main port and a side opening formed by a radially and longitudinally extending slit the main port configured to receive the main fiber optic cable into the enclosure chamber; wherein the radially and longitudinally extending slit enables a section of the main fiber optic cable to be inserted laterally into the main port, and each of the first and second endplate assemblies (100, 200) when mounted on the enclosure, closes the side opening of the main port to prevent lateral removal of the main fiber optic cable from the main port; and wherein a splice tray is disposed in the enclosure chamber.