A pipette tip coupling device for coupling a pipette tip to a pipette device, the pipette tip coupling device comprising: a central body comprising: a proximal shank including a proximal end face; a distal stem portion having a first diameter; an end plate having a second diameter greater than the first diameter wherein the end plate is distal to the distal stem portion; and an open-ended interior circumscribing surface forming an open passageway extending longitudinally from the proximal end face through the end plate; an elastomeric element disposed around the distal stem portion and adjacent to the end plate; an expanding collet disposed around the central body, the expanding collet comprising: an annular base comprising: a proximal disk portion (171, 173); and a distal collet stem end portion (174, 176); characterized in that the annular base further comprises a plurality of circumferentially spaced apart, flexible, upwardly extending arms, wherein each of the plurality of circumferentially spaced apart, flexible, upwardly extending arms comprises: a distal end attached to the disk portion; a proximal free arm portion having an inner surface; and an outer surface including a radially outwardly extending stop disk segment; and wherein the proximal free arm portions of the plurality of circumferentially spaced apart, flexible, upwardly extending arms are capable of expanding radially relative to the central body between an unexpanded state with a first circumference and an expanded state with a second circumference that is larger than the first circumference. a proximal shank including a proximal end face; a distal stem portion having a first diameter; an end plate having a second diameter greater than the first diameter wherein the end plate is distal to the distal stem portion; and an open-ended interior circumscribing surface forming an open passageway extending longitudinally from the proximal end face through the end plate; an elastomeric element disposed around the distal stem portion and adjacent to the end plate; an expanding collet disposed around the central body, the expanding collet comprising: an annular base comprising: a proximal disk portion (171, 173); and a distal collet stem end portion (174, 176); characterized in that the annular base further comprises a plurality of circumferentially spaced apart, flexible, upwardly extending arms, wherein each of the plurality of circumferentially spaced apart, flexible, upwardly extending arms comprises: a distal end attached to the disk portion; a proximal free arm portion having an inner surface; and an outer surface including a radially outwardly extending stop disk segment; and wherein the proximal free arm portions of the plurality of circumferentially spaced apart, flexible, upwardly extending arms are capable of expanding radially relative to the central body between an unexpanded state with a first circumference and an expanded state with a second circumference that is larger than the first circumference. a proximal disk portion (171, 173); and a distal collet stem end portion (174, 176); characterized in that the annular base further comprises a plurality of circumferentially spaced apart, flexible, upwardly extending arms, wherein each of the plurality of circumferentially spaced apart, flexible, upwardly extending arms comprises: a distal end attached to the disk portion; a proximal free arm portion having an inner surface; and an outer surface including a radially outwardly extending stop disk segment; and wherein the proximal free arm portions of the plurality of circumferentially spaced apart, flexible, upwardly extending arms are capable of expanding radially relative to the central body between an unexpanded state with a first circumference and an expanded state with a second circumference that is larger than the first circumference. a distal end attached to the disk portion; a proximal free arm portion having an inner surface; and an outer surface including a radially outwardly extending stop disk segment; and wherein the proximal free arm portions of the plurality of circumferentially spaced apart, flexible, upwardly extending arms are capable of expanding radially relative to the central body between an unexpanded state with a first circumference and an expanded state with a second circumference that is larger than the first circumference.