A method of coating a metal medical device, especially vascular stent, comprising: - providing a metal medical device; - first treatment of said medical device by gaseous plasma (step 1) to enable removal of any surface impurities by oxidising plasma radicals and surface activation of said device by combined effects of oxidising plasma radicals and ultraviolet radiation, wherein said first plasma treatment comprises removal of impurities, activation and nanostructuring of said surface in order to assure a contaminant-free surface with a nano-structured topography; - immersing said medical device in a hydrothermal bath within 10 to 1.000 s, especially less than six minutes, after the said first treatment by gaseous plasma has been accomplished; - depositing of a titanium oxide layer (step 2) on the surface of the metal medical device by means of a hydrothermal technique, wherein said hydrothermal technique provides coating of the surface with said nanostructured titanium oxide layer consisting of nanoparticles and/or nanostructures of various morphologies like rods, needles, leaves, pores, pits, octahedral, squares with the dimension between 10 to 400 nm in width, 10 to 300 nm in height and thickness of titanium oxide layer ranging from 20 to 1.500 nm; - removal of said medical device from the hydrothermal bath and installing in a plasma reactor; - exposing of said medical device (step 3) with deposited titanium oxide layer on the surface of said metal medical device to highly reactive oxygen plasma in a second plasma treatment to optimise the titanium oxide coating, wherein said second plasma treatment of titanium oxide layer is provided with fluencies of OH or O radicals in the range of 10 22 to 10 26 m -2, preferably between 10 24 and 10 25 m -2. - providing a metal medical device; - first treatment of said medical device by gaseous plasma (step 1) to enable removal of any surface impurities by oxidising plasma radicals and surface activation of said device by combined effects of oxidising plasma radicals and ultraviolet radiation, wherein said first plasma treatment comprises removal of impurities, activation and nanostructuring of said surface in order to assure a contaminant-free surface with a nano-structured topography; - immersing said medical device in a hydrothermal bath within 10 to 1.000 s, especially less than six minutes, after the said first treatment by gaseous plasma has been accomplished; - depositing of a titanium oxide layer (step 2) on the surface of the metal medical device by means of a hydrothermal technique, wherein said hydrothermal technique provides coating of the surface with said nanostructured titanium oxide layer consisting of nanoparticles and/or nanostructures of various morphologies like rods, needles, leaves, pores, pits, octahedral, squares with the dimension between 10 to 400 nm in width, 10 to 300 nm in height and thickness of titanium oxide layer ranging from 20 to 1.500 nm; - removal of said medical device from the hydrothermal bath and installing in a plasma reactor; - exposing of said medical device (step 3) with deposited titanium oxide layer on the surface of said metal medical device to highly reactive oxygen plasma in a second plasma treatment to optimise the titanium oxide coating, wherein said second plasma treatment of titanium oxide layer is provided with fluencies of OH or O radicals in the range of 10 22 to 10 26 m -2, preferably between 10 24 and 10 25 m -2.