A system for measuring an analyte from blood over a measuring area comprising: a. a disposable housing (810, 801) having an opening for receiving the blood for measuring the analyte and at least two disposable electrical contacts (816, 818) for performing the measurement; wherein the disposable housing comprises a single skin piercing element, a single measuring element sensitive to the analyte from the blood and a coupling mechanism for attaching the housing over the measuring area; b. a reusable housing (820, 801) having at least two reusable electrical contacts (826, 828) corresponding to the at least two disposable electrical contacts (816, 818); and comprising a power source, a controller, a transponder and a mechanical actuator for performing and communicating the measurement; c. wherein the reusable housing is associated with the disposable housing over the at least two corresponding reusable electrical contacts (826, 828) and the at least two disposable electrical contacts (816, 818); and wherein the mechanical actuator is coupled to and manipulates the single skin piercing element and the single measuring element; d. a remote controller adapted for wireless communication with the transponder for communicating a triggering signal; e. wherein the system is adapted such that the triggering signal triggers the mechanical actuator to manipulate the movement of the single skin piercing element and the single measuring element therein triggering the measurement of the analyte within the reusable housing and communicating the measurement to the remote controller; and f. wherein the remote controller is further adapted to receive the analyte measurement and to display it in the form of a concentration of the analyte in the blood. a. a disposable housing (810, 801) having an opening for receiving the blood for measuring the analyte and at least two disposable electrical contacts (816, 818) for performing the measurement; wherein the disposable housing comprises a single skin piercing element, a single measuring element sensitive to the analyte from the blood and a coupling mechanism for attaching the housing over the measuring area; b. a reusable housing (820, 801) having at least two reusable electrical contacts (826, 828) corresponding to the at least two disposable electrical contacts (816, 818); and comprising a power source, a controller, a transponder and a mechanical actuator for performing and communicating the measurement; c. wherein the reusable housing is associated with the disposable housing over the at least two corresponding reusable electrical contacts (826, 828) and the at least two disposable electrical contacts (816, 818); and wherein the mechanical actuator is coupled to and manipulates the single skin piercing element and the single measuring element; d. a remote controller adapted for wireless communication with the transponder for communicating a triggering signal; e. wherein the system is adapted such that the triggering signal triggers the mechanical actuator to manipulate the movement of the single skin piercing element and the single measuring element therein triggering the measurement of the analyte within the reusable housing and communicating the measurement to the remote controller; and f. wherein the remote controller is further adapted to receive the analyte measurement and to display it in the form of a concentration of the analyte in the blood.