A compound, having the following structure: wherein, the E ring is selected from: and in the E ring, each R 0 is independently selected from: -H, -D, C 1-10 linear/branched alkyl, -N(C 0-10 alkyl)(C 0-10 alkyl), -OC 0-10 alkyl, -CO(C 0-10 alkyl) and C 3-10 cycloalkyl, wherein H attached to the C atoms or heteroatoms may be substituted with deuterium; R 1 is selected from: -H, -D, -O heterocycloalkyl, -N heterocycloalkyl, C 1-10 linear/branched alkyl, C 3-10 cycloalkyl, -OC 0-10 alkyl, -N(C 0-10 alkyl)( 0-10 alkyl), -SO 2 (C 0-10 alkyl), -CO(C 0-10 alkyl), -O-phenyl, -S(C 0-10 alkyl), -N heterocycloaryl, -O heterocycloaryl and -S heterocycloaryl, wherein H attached to the C atoms or heteroatoms may be substituted with deuterium;R 2 is selected from: -NH 2, -NHD, -ND 2 and -NO 2; R 3 is selected from: -H, halogen, -OC 0-10 alkyl, -CO(C 0-10 alkyl) and C 1-10 linear/branched alkyl; R 4 is -C≡C-R 10; R 5, R 6 and R 7 are independently selected from: -H, halogen, -CN, C 1-3 linear/branched alkyl, -OC 0-3 alkyl, - CO(C 0-3 alkyl) and C 1-3 linear/branched alkyl containing N; R 8 and R 9 are independently selected from: -H, -D and C 1-3 linear/branched alkyl, wherein one or more H atoms attached to the C atoms may be substituted with deuterium; R 10 is selected from: -H, -D, C 1-5 linear/branched alkyl, C 3-10 cycloalkyl and wherein one or more H atoms attached to the C atoms may be substituted with deuterium; R 11 and R 12 are independently selected from: -H, -D, -CF 3, -CHF 2, -CH 2 F, C 1-10 linear/branched alkyl, -CH=C(C 0-10 alkyl)(C 0-10 alkyl), -C≡C(C 0-10 alkyl), C 3-10 cycloalkyl, an aromatic five-membered cyclic group and an aromatic six-membered cyclic group, or R 11 and R 12, together with carbon atoms between R 11 and R 12, form C 3-8 cycloalkyl or C 3-8 heterocycloalkyl containing -O- or -S-, C 4-9 fused cycloalkyl, C 5-10 spiro cycloalkyl, C 4-9 bridged cycloalkyl, C 3-7 cyclolactam, C 3-7 cyclic lactone or C 3-7 cyclic ketone, wherein one or more H atoms attached to the C atoms or heteroatoms may be substituted with deuterium; and at least one of R 1, R 4, R 8 and R 9 contains a deuterium atom; or a pharmaceutically acceptable salt, a stereoisomer, an ester, and a solvate thereof. the E ring is selected from: and in the E ring, each R 0 is independently selected from: -H, -D, C 1-10 linear/branched alkyl, -N(C 0-10 alkyl)(C 0-10 alkyl), -OC 0-10 alkyl, -CO(C 0-10 alkyl) and C 3-10 cycloalkyl, wherein H attached to the C atoms or heteroatoms may be substituted with deuterium; R 1 is selected from: -H, -D, -O heterocycloalkyl, -N heterocycloalkyl, C 1-10 linear/branched alkyl, C 3-10 cycloalkyl, -OC 0-10 alkyl, -N(C 0-10 alkyl)( 0-10 alkyl), -SO 2 (C 0-10 alkyl), -CO(C 0-10 alkyl), -O-phenyl, -S(C 0-10 alkyl), -N heterocycloaryl, -O heterocycloaryl and -S heterocycloaryl, wherein H attached to the C atoms or heteroatoms may be substituted with deuterium;R 2 is selected from: -NH 2, -NHD, -ND 2 and -NO 2; R 3 is selected from: -H, halogen, -OC 0-10 alkyl, -CO(C 0-10 alkyl) and C 1-10 linear/branched alkyl; R 4 is -C≡C-R 10; R 5, R 6 and R 7 are independently selected from: -H, halogen, -CN, C 1-3 linear/branched alkyl, -OC 0-3 alkyl, - CO(C 0-3 alkyl) and C 1-3 linear/branched alkyl containing N; R 8 and R 9 are independently selected from: -H, -D and C 1-3 linear/branched alkyl, wherein one or more H atoms attached to the C atoms may be substituted with deuterium; R 10 is selected from: -H, -D, C 1-5 linear/branched alkyl, C 3-10 cycloalkyl and wherein one or more H atoms attached to the C atoms may be substituted with deuterium; R 11 and R 12 are independently selected from: -H, -D, -CF 3, -CHF 2, -CH 2 F, C 1-10 linear/branched alkyl, -CH=C(C 0-10 alkyl)(C 0-10 alkyl), -C≡C(C 0-10 alkyl), C 3-10 cycloalkyl, an aromatic five-membered cyclic group and an aromatic six-membered cyclic group, or R 11 and R 12, together with carbon atoms between R 11 and R 12, form C 3-8 cycloalkyl or C 3-8 heterocycloalkyl containing -O- or -S-, C 4-9 fused cycloalkyl, C 5-10 spiro cycloalkyl, C 4-9 bridged cycloalkyl, C 3-7 cyclolactam, C 3-7 cyclic lactone or C 3-7 cyclic ketone, wherein one or more H atoms attached to the C atoms or heteroatoms may be substituted with deuterium; and at least one of R 1, R 4, R 8 and R 9 contains a deuterium atom; or a pharmaceutically acceptable salt, a stereoisomer, an ester, and a solvate thereof.