A system for directing a device to a target region within a cavity of a body, the system comprising a first catheter comprising a handle at a proximate end, an expandable cage at a distal end, and a lumen therebetween, an outer sheath axially movable to alternatively cover and expose the expandable cage to permit the expandable cage to move from a collapsed delivery mode to an expanded deployed mode, the expandable cage comprising a plurality of members (32, 34) that expand to engage a wall of the body cavity to stabilize the expandable cage within the cavity, the expandable cage being rotatable within the cavity when the handle of the first catheter is rotated; a second catheter positioned within the lumen of the first catheter, the second catheter comprising a proximal end that passes through the handle of the first catheter; characterized in that the second catheter has a distal end that passes through a hub, the second catheter comprising a lumen therethrough, the second catheter being axially and rotationally movable within the lumen of the first catheter in association with axial and rotational movement of the expandable cage; a plurality of pairs of wires (36, 38), each wire (36, 38) having a first end (36a, 36b, 38a, 38b) secured within the handle of the first catheter and a second opposite end secured at the hub of the second catheter, each pair of wires being (36, 38) movable in conjunction with each other by manipulation of the handle so as to move the hub, and thereby the distal end of the second catheter, a first pair of wires movable to move the hub in a first direction and a second pair of wires movable to move the hub in a second direction; whereby, through manipulation of the handle and wires (36, 38), the distal end of the second catheter may be rotated within the cavity while moved in the first and second direction. a first catheter comprising a handle at a proximate end, an expandable cage at a distal end, and a lumen therebetween, an outer sheath axially movable to alternatively cover and expose the expandable cage to permit the expandable cage to move from a collapsed delivery mode to an expanded deployed mode, the expandable cage comprising a plurality of members (32, 34) that expand to engage a wall of the body cavity to stabilize the expandable cage within the cavity, the expandable cage being rotatable within the cavity when the handle of the first catheter is rotated; a second catheter positioned within the lumen of the first catheter, the second catheter comprising a proximal end that passes through the handle of the first catheter; characterized in that the second catheter has a distal end that passes through a hub, the second catheter comprising a lumen therethrough, the second catheter being axially and rotationally movable within the lumen of the first catheter in association with axial and rotational movement of the expandable cage; a plurality of pairs of wires (36, 38), each wire (36, 38) having a first end (36a, 36b, 38a, 38b) secured within the handle of the first catheter and a second opposite end secured at the hub of the second catheter, each pair of wires being (36, 38) movable in conjunction with each other by manipulation of the handle so as to move the hub, and thereby the distal end of the second catheter, a first pair of wires movable to move the hub in a first direction and a second pair of wires movable to move the hub in a second direction; whereby, through manipulation of the handle and wires (36, 38), the distal end of the second catheter may be rotated within the cavity while moved in the first and second direction.