mhurhangee/ep-ind-claims huggingface dataset:
A modified laminin selected from a modified laminin comprising a fibronectin fragment having a cell adhesion domain, wherein the fragment having a cell adhesion domain is a fragment comprising the 7th to 10th type III modules of human fibronectin, fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, a modified laminin comprising globular domains 4 and/or 5 of a laminin α1 chain fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, a modified laminin comprising a perlecan fragment having a growth factor binding domain, wherein the fragment having a growth factor binding domain is a fragment comprising the domains I to III of perlecan, fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, wherein the laminin E8 fragment is laminin α5β1γ1 E8 fragment or laminin α3β3γ2 E8 fragment. a modified laminin comprising a fibronectin fragment having a cell adhesion domain, wherein the fragment having a cell adhesion domain is a fragment comprising the 7th to 10th type III modules of human fibronectin, fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, a modified laminin comprising globular domains 4 and/or 5 of a laminin α1 chain fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, a modified laminin comprising a perlecan fragment having a growth factor binding domain, wherein the fragment having a growth factor binding domain is a fragment comprising the domains I to III of perlecan, fused to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of a heterotrimeric laminin E8 fragment having integrin binding activity, wherein the laminin E8 fragment is laminin α5β1γ1 E8 fragment or laminin α3β3γ2 E8 fragment.
A pharmaceutical composition for use in preventing or treating non-alcoholic fatty liver disease (NAFLD), comprising trametinib or a pharmaceutically acceptable salt thereof.
Method for providing an object with a protective coating of silicone elastomer, wherein the method is free of volatile organic compounds (VOC's) and comprises the steps of a) providing a liquid composition comprising room temperature vulcanisation silicone elastomers, wherein said liquid composition comprising RTV silicone elastomer has a viscosity of between 2500 mPa·s to 10000 mPa·s, and wherein the composition further comprises between 0. 1% to 0.5% w/w of a thixotropic additive based on the total weight of the composition. b) spraying a first layer of said liquid composition on the surface of said object, thereby coating the surface of the object with the liquid composition, wherein the object is comprised of polymeric foam selected from the group consisting of polyurethane, polyether, silicone, natural latex, polystyrene, polyethylene, polypropylene, or mixtures thereof, preferably polyurethane, and wherein spraying is performed at an air pressure of at least 3 bar, wherein the first layer covering the surface of the object, has a thickness of at most 1 mm c) allowing polymerization of the first layer of RTV silicone elastomers, and d) optionally, providing on said first layer at least one additional layer of said composition comprising a silicon elastomer. a) providing a liquid composition comprising room temperature vulcanisation silicone elastomers, wherein said liquid composition comprising RTV silicone elastomer has a viscosity of between 2500 mPa·s to 10000 mPa·s, and wherein the composition further comprises between 0. 1% to 0.5% w/w of a thixotropic additive based on the total weight of the composition. b) spraying a first layer of said liquid composition on the surface of said object, thereby coating the surface of the object with the liquid composition, wherein the object is comprised of polymeric foam selected from the group consisting of polyurethane, polyether, silicone, natural latex, polystyrene, polyethylene, polypropylene, or mixtures thereof, preferably polyurethane, and wherein spraying is performed at an air pressure of at least 3 bar, wherein the first layer covering the surface of the object, has a thickness of at most 1 mm c) allowing polymerization of the first layer of RTV silicone elastomers, and d) optionally, providing on said first layer at least one additional layer of said composition comprising a silicon elastomer.
A motor, comprising: a stator for receiving electrical power; a rotor arranged coaxially within the stator and having one or more magnets arranged thereon, the rotor comprising a rotor housing having an inner wall, the magnets being arranged around the housing, and wherein the rotor also comprises a conduit having an axial component for the flow of a coolant between a first end of the rotor and a second distal end of the rotor; the rotor further comprising radial fluid conduits, the radial fluid conduits being fluidly coupled to the conduit having an axial component and arranged in use to receive coolant from or provide coolant to the conduit having an axial component, the inner wall having one or more fluid paths for the flow of coolant, thereby to cool the rotor; at least one fluid impeller arranged at the first end of the rotor and arranged to rotate with the rotor characterised in that the at least one fluid impeller is arranged to remove and/or maintain rotary movement of fluid leaving the motor, said one or more fluid paths being tortuous fluid paths, and in that the impeller is a unitary moulded component having guide ribs to guide coolant, and in that said impeller is arranged to guide the fluid towards the rotor axis for removal from the motor. a stator for receiving electrical power; a rotor arranged coaxially within the stator and having one or more magnets arranged thereon, the rotor comprising a rotor housing having an inner wall, the magnets being arranged around the housing, and wherein the rotor also comprises a conduit having an axial component for the flow of a coolant between a first end of the rotor and a second distal end of the rotor; the rotor further comprising radial fluid conduits, the radial fluid conduits being fluidly coupled to the conduit having an axial component and arranged in use to receive coolant from or provide coolant to the conduit having an axial component, the inner wall having one or more fluid paths for the flow of coolant, thereby to cool the rotor; at least one fluid impeller arranged at the first end of the rotor and arranged to rotate with the rotor characterised in that the at least one fluid impeller is arranged to remove and/or maintain rotary movement of fluid leaving the motor, said one or more fluid paths being tortuous fluid paths, and in that the impeller is a unitary moulded component having guide ribs to guide coolant, and in that said impeller is arranged to guide the fluid towards the rotor axis for removal from the motor.
A device for coupling a drawer to a runner of a drawer slide, comprising - a fastening means (10, 11) for fastening the device to the drawer, - a detent element (13, 13') for latchingly connecting the device to the runner, - an actuation element for moving the detent element (13, 13') into a coupled position, in which the detent element (13, 13') is latchingly connected to the runner, and into a decoupled position, in which the detent element (13, 13') is not connected to the runner, - the fastening means (10, 11), the detent element (13, 13') and the actuation element are integrally interconnected, forming a single coupling part, - the coupling part has two longitudinal struts (12, 12') extending parallel to each other, on each outer sideof which the detent element (13, 13')is formed, - that the longitudinal struts (12, 12') having a first end are formed on a base element of the coupling part,said element having the fastening means (10, 11), and - that the actuation element,on an opposing side of the two longitudinal struts (12, 12'), protrudes from the same, characterized in that the actuation element has a connecting strut which connects the first longitudinal strut to the second longitudinal strut, wherein the connecting strut has an indentation directed toward the base element. - a fastening means (10, 11) for fastening the device to the drawer, - a detent element (13, 13') for latchingly connecting the device to the runner, - an actuation element for moving the detent element (13, 13') into a coupled position, in which the detent element (13, 13') is latchingly connected to the runner, and into a decoupled position, in which the detent element (13, 13') is not connected to the runner, - the fastening means (10, 11), the detent element (13, 13') and the actuation element are integrally interconnected, forming a single coupling part, - the coupling part has two longitudinal struts (12, 12') extending parallel to each other, on each outer sideof which the detent element (13, 13')is formed, - that the longitudinal struts (12, 12') having a first end are formed on a base element of the coupling part,said element having the fastening means (10, 11), and - that the actuation element,on an opposing side of the two longitudinal struts (12, 12'), protrudes from the same,
A separation device (703a, 703b) for shearing a moving glass sheet without having to score the moving glass sheet, the device comprising: a separation mechanism (902a, 902b, 902c, 902d, 904a, 904b, 904c, 904d) that generates a stress profile within the moving glass sheet, characterized in that: the stress profile produces a crack in a predefined location within the moving glass sheet to shear off at least one edge (706a, 706b) of the moving glass sheet; and the separation mechanism includes a pair of rolls (902a/902c, 902b/902d) through which passes the moving glass sheet, where the pair of rolls includes a first roll (902a, 902b) that has a curved surface and a tiltable second roll (902c, 902d) that has a flat surface that is tilted with respect to a face of the moving glass sheet and also interfaces with the moving glass sheet to generate the stress profile within the moving glass sheet. the stress profile produces a crack in a predefined location within the moving glass sheet to shear off at least one edge (706a, 706b) of the moving glass sheet; and the separation mechanism includes a pair of rolls (902a/902c, 902b/902d) through which passes the moving glass sheet, where the pair of rolls includes a first roll (902a, 902b) that has a curved surface and a tiltable second roll (902c, 902d) that has a flat surface that is tilted with respect to a face of the moving glass sheet and also interfaces with the moving glass sheet to generate the stress profile within the moving glass sheet.
A vacuum pump, in particular a turbomolecular pump, comprising at least one pump mechanism for pumping gas along a pump channel extending from an inlet to an outlet of the vacuum pump, wherein the pump channel extends through at least one first gap (83a, 83b, 83c) in which a pumping function is performed during operation of the vacuum pump, wherein the first gap (83a, 83b, 83c) is a Holweck gap, wherein at least one second gap (85, 85a) is provided in which no pumping function is performed during operation of the vacuum pump, wherein the pump channel extends through the second gap, wherein the second gap (85, 85a) is larger by at least a factor, in particular 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, 8 times, 9 times or 10 times, than the first gap (83a, 83b, 83c), wherein the second gap (85, 85a) is provided between two components (82, 128) of the vacuum pump which, during operation of the vacuum pump, do not interact such that they effect a pumping function, wherein the two components between which the second gap (85, 85a) is provided are a rotating component and a stationary component, wherein the second gap (85, 85a) and the first gap (83a, 83b, 83c) extend parallel to one another and, with respect to an axis of rotation of the rotating component, extend concentrically disposed within one another, and wherein the vacuum pump comprises a sealing gas inlet. at least one pump mechanism for pumping gas along a pump channel extending from an inlet to an outlet of the vacuum pump, wherein the pump channel extends through at least one first gap (83a, 83b, 83c) in which a pumping function is performed during operation of the vacuum pump, wherein the first gap (83a, 83b, 83c) is a Holweck gap, wherein at least one second gap (85, 85a) is provided in which no pumping function is performed during operation of the vacuum pump, wherein the pump channel extends through the second gap, wherein the second gap (85, 85a) is larger by at least a factor, in particular 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, 8 times, 9 times or 10 times, than the first gap (83a, 83b, 83c), wherein the second gap (85, 85a) is provided between two components (82, 128) of the vacuum pump which, during operation of the vacuum pump, do not interact such that they effect a pumping function, wherein the two components between which the second gap (85, 85a) is provided are a rotating component and a stationary component, wherein the second gap (85, 85a) and the first gap (83a, 83b, 83c) extend parallel to one another and, with respect to an axis of rotation of the rotating component, extend concentrically disposed within one another, and wherein the vacuum pump comprises a sealing gas inlet.
An electronic device comprising: a display; at least one processor electrically connected to the display; and a memory electrically connected to the at least one processor and including instructions, wherein the instructions, when executed by the at least one processor, cause the at least one processor to: display a user interface in the form of a bar indicating a time interval on a first region of a screen displayed by the display; display, in the bar, a text or an image representing information regarding the bar; receive a user input for scrolling the first region; determine whether a part of the text or the image is located on a second region included in the first region; fix the text or the image on the second region during a scroll operation according to the user input when the part of the text or the image is located on the second region; compare a size of the text or the image with a size of the bar remaining on the screen; and modify an arrangement of the text or the image when the size of the text or the image is larger than the size of the bar remaining on the screen. a display; at least one processor electrically connected to the display; and a memory electrically connected to the at least one processor and including instructions, wherein the instructions, when executed by the at least one processor, cause the at least one processor to: display a user interface in the form of a bar indicating a time interval on a first region of a screen displayed by the display; display, in the bar, a text or an image representing information regarding the bar; receive a user input for scrolling the first region; determine whether a part of the text or the image is located on a second region included in the first region; fix the text or the image on the second region during a scroll operation according to the user input when the part of the text or the image is located on the second region; compare a size of the text or the image with a size of the bar remaining on the screen; and modify an arrangement of the text or the image when the size of the text or the image is larger than the size of the bar remaining on the screen. display a user interface in the form of a bar indicating a time interval on a first region of a screen displayed by the display; display, in the bar, a text or an image representing information regarding the bar; receive a user input for scrolling the first region; determine whether a part of the text or the image is located on a second region included in the first region; fix the text or the image on the second region during a scroll operation according to the user input when the part of the text or the image is located on the second region; compare a size of the text or the image with a size of the bar remaining on the screen; and modify an arrangement of the text or the image when the size of the text or the image is larger than the size of the bar remaining on the screen.
A computer-implemented method for generating and/or augmenting an execution protocol for at least one standard operating procedure, SOP, in an industrial plant, comprising the steps of: • providing at least one SOP of the plant, said SOP comprising a plurality of steps (2a-2g); • providing measurement data that has been acquired during multiple executions of the at least one SOP and is indicative of actions performed in the plant that modify the state and/or the behavior of the plant or any part thereof for the purpose of executing the SOP; the method being characterized in the steps: • for each step (2a-2g) of the SOP, determining, from the measurement data, a subset (3a-3g) of the measurement data that is indicative of actions performed for the purpose of executing this particular step (2a-2g) of the SOP; and • aggregating the subset (3a-3g) of the measurement data determined for each step (2a-2g) of the SOP into at least one instruction (4a-4g) for executing this particular step (2a-2g) of the SOP, wherein this instruction (4a-4g) is part of the sought protocol. • providing at least one SOP of the plant, said SOP comprising a plurality of steps (2a-2g); • providing measurement data that has been acquired during multiple executions of the at least one SOP and is indicative of actions performed in the plant that modify the state and/or the behavior of the plant or any part thereof for the purpose of executing the SOP; the method being characterized in the steps: • for each step (2a-2g) of the SOP, determining, from the measurement data, a subset (3a-3g) of the measurement data that is indicative of actions performed for the purpose of executing this particular step (2a-2g) of the SOP; and • aggregating the subset (3a-3g) of the measurement data determined for each step (2a-2g) of the SOP into at least one instruction (4a-4g) for executing this particular step (2a-2g) of the SOP, wherein this instruction (4a-4g) is part of the sought protocol. • for each step (2a-2g) of the SOP, determining, from the measurement data, a subset (3a-3g) of the measurement data that is indicative of actions performed for the purpose of executing this particular step (2a-2g) of the SOP; and • aggregating the subset (3a-3g) of the measurement data determined for each step (2a-2g) of the SOP into at least one instruction (4a-4g) for executing this particular step (2a-2g) of the SOP, wherein this instruction (4a-4g) is part of the sought protocol.
A pant-type article, said article comprising: a first panel and a second panel, said first and second panels being joined by first and second side seams (12, 12') to form a waist opening at a first transverse end of said article; said first and second panels (20, 30) being further joined by a crotch region joint in a crotch region spaced from said waist opening to thereby form a pair of leg openings (60, 70) at a second transverse end of said article; said crotch region joint comprising a crotch seam extending substantially perpendicular to said first and second side seams (12, 12') and spaced therefrom, said crotch seam having a first end and a second end; said crotch region joint further comprising a first inner leg seam extending a first distance from said first end of said crotch seam to said second transverse end of said article, and a second inner leg seam extending said first distance from said second end of said crotch seam to said second transverse end of said article; said article having an interior and an exterior; said article further comprising a crotch flap located in the interior of said article, said crotch flap comprising material of said first and second panels (20, 30), characterised in that said crotch flap extends from said crotch seam by a second distance (W') substantially equal to said first distance. a first panel and a second panel, said first and second panels being joined by first and second side seams (12, 12') to form a waist opening at a first transverse end of said article; said first and second panels (20, 30) being further joined by a crotch region joint in a crotch region spaced from said waist opening to thereby form a pair of leg openings (60, 70) at a second transverse end of said article; said crotch region joint comprising a crotch seam extending substantially perpendicular to said first and second side seams (12, 12') and spaced therefrom, said crotch seam having a first end and a second end; said crotch region joint further comprising a first inner leg seam extending a first distance from said first end of said crotch seam to said second transverse end of said article, and a second inner leg seam extending said first distance from said second end of said crotch seam to said second transverse end of said article; said article having an interior and an exterior; said article further comprising a crotch flap located in the interior of said article, said crotch flap comprising material of said first and second panels (20, 30), characterised in that said crotch flap extends from said crotch seam by a second distance (W') substantially equal to said first distance.
A sanitary fitting apparatus comprising a sanitary fitting for discharging a fluid, a preparation device (5, 7) for providing at least one type of prepared fluid, wherein the preparation device has one or more preparation components (5a, 5b, 5c, 5d, 7), and a central distribution device which is connected at least to the preparation device (5, 7), comprising an energy distribution component which is constructed to provide electrical energy for at least one preparation component (5a, 5b, 5c, 5d, 7) of the preparation device (5, 7), characterised in that the distribution device is constructed to control the overall electrical power of all the electrical energy discharged by means of the central distribution device below a predetermined maximum overall power, wherein the distribution device is constructed to measure the electrical power received by the respective preparation component (5a, 5b, 5c, 5d, 7a) of the preparation device (5, 7) and to control the individual electrical power for each preparation component (5a, 5b, 5c, 5d, 7a) in a predetermined individual power range. a sanitary fitting for discharging a fluid, a preparation device (5, 7) for providing at least one type of prepared fluid, wherein the preparation device has one or more preparation components (5a, 5b, 5c, 5d, 7), and a central distribution device which is connected at least to the preparation device (5, 7), comprising an energy distribution component which is constructed to provide electrical energy for at least one preparation component (5a, 5b, 5c, 5d, 7) of the preparation device (5, 7), characterised in that the distribution device is constructed to control the overall electrical power of all the electrical energy discharged by means of the central distribution device below a predetermined maximum overall power, wherein the distribution device is constructed to measure the electrical power received by the respective preparation component (5a, 5b, 5c, 5d, 7a) of the preparation device (5, 7) and to control the individual electrical power for each preparation component (5a, 5b, 5c, 5d, 7a) in a predetermined individual power range.