A clipping system (100, 200) for treating tissue, comprising: an insertion device (104, 204) extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the insertion device including a plurality of longitudinal slots extending through a wall thereof and along a distal portion thereof such that the longitudinal slots are open to the channel and the distal end of the insertion device; a clip releasably received within the distal portion of the insertion device, the clip including a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, and a pair of clip arms, proximal ends of which are slidably received within the channel of the capsule to move the clip arms between an open configuration, in which distal ends thereof are separated from one another to receive a tissue therebetween, and a closed configuration, in which the distal ends are drawn toward one another to grip tissue therebetween; a collet (106, 206) slidably mounted over the insertion device and movable between an insertion configuration, in which the collet is positioned over the distal portion of the insertion device to press the distal portion against the capsule and to hold the capsule therein, and a deployed configuration, in which the collet is proximal the distal portion so that the clip is releasable from the distal portion of the insertion device; and a control member (116, 216) extending through the channel of the insertion device to be coupled to the proximal ends of the clip arms and a portion of the collet so that movement of the clip between the open and closed configurations and movement of the collet between the insertion configuration and the deployed configuration is controlled via a longitudinal movement of the control member relative to the insertion device. an insertion device (104, 204) extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the insertion device including a plurality of longitudinal slots extending through a wall thereof and along a distal portion thereof such that the longitudinal slots are open to the channel and the distal end of the insertion device; a clip releasably received within the distal portion of the insertion device, the clip including a capsule extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, and a pair of clip arms, proximal ends of which are slidably received within the channel of the capsule to move the clip arms between an open configuration, in which distal ends thereof are separated from one another to receive a tissue therebetween, and a closed configuration, in which the distal ends are drawn toward one another to grip tissue therebetween; a collet (106, 206) slidably mounted over the insertion device and movable between an insertion configuration, in which the collet is positioned over the distal portion of the insertion device to press the distal portion against the capsule and to hold the capsule therein, and a deployed configuration, in which the collet is proximal the distal portion so that the clip is releasable from the distal portion of the insertion device; and a control member (116, 216) extending through the channel of the insertion device to be coupled to the proximal ends of the clip arms and a portion of the collet so that movement of the clip between the open and closed configurations and movement of the collet between the insertion configuration and the deployed configuration is controlled via a longitudinal movement of the control member relative to the insertion device.