A control device controlling at least one device (311 to 313, 321, 322, 331, 332) included in a production line producing a product, the control device comprising: a monitoring portion (11, 102) configured to monitor a statistic obtained by performing a multivariate analysis on a plurality of parameters related to an operation of the at least one device (311 to 313, 321, 322, 331, 332); an extraction portion (12, 102) configured to extract, from the plurality of parameters, a predetermined number of higher-order parameters in terms of an influence degree on fluctuation of the statistic, in response to a fact that the fluctuation of the statistic is larger than a reference; a generation portion (13, 102) configured to generate a plurality of experimental patterns in which combinations of target values of the predetermined number of higher-order parameters are different from each other according to an experimental design method; an experiment execution portion (14, 102) configured to acquire, for each of the plurality of experimental patterns, a measurement result of a specific parameter indicating quality of the product when the at least one device (311 to 313, 321, 322, 331, 332) is controlled according to the experimental pattern; a setting portion (15, 102) configured to perform variance analysis on the measurement results of the plurality of experimental patterns, and calculate a fluctuation S, a variance V, and a contribution ratio p of each parameter, and set a new target value of the predetermined number of higher-order parameters according to a fluctuation direction and a fluctuation amount of the specific parameter, in order to stabilize a value of the specific parameter within a management range based on the measurement result; and a controller (10, 102) configured to control the at least one device (311 to 313, 321, 322, 331, 332) such that the predetermined number of higher-order parameters approaches the new target value. a monitoring portion (11, 102) configured to monitor a statistic obtained by performing a multivariate analysis on a plurality of parameters related to an operation of the at least one device (311 to 313, 321, 322, 331, 332); an extraction portion (12, 102) configured to extract, from the plurality of parameters, a predetermined number of higher-order parameters in terms of an influence degree on fluctuation of the statistic, in response to a fact that the fluctuation of the statistic is larger than a reference; a generation portion (13, 102) configured to generate a plurality of experimental patterns in which combinations of target values of the predetermined number of higher-order parameters are different from each other according to an experimental design method; an experiment execution portion (14, 102) configured to acquire, for each of the plurality of experimental patterns, a measurement result of a specific parameter indicating quality of the product when the at least one device (311 to 313, 321, 322, 331, 332) is controlled according to the experimental pattern; a setting portion (15, 102) configured to perform variance analysis on the measurement results of the plurality of experimental patterns, and calculate a fluctuation S, a variance V, and a contribution ratio p of each parameter, and set a new target value of the predetermined number of higher-order parameters according to a fluctuation direction and a fluctuation amount of the specific parameter, in order to stabilize a value of the specific parameter within a management range based on the measurement result; and a controller (10, 102) configured to control the at least one device (311 to 313, 321, 322, 331, 332) such that the predetermined number of higher-order parameters approaches the new target value.