A system for obtaining images within a lumen or cavity, the system comprising: an imaging probe configured for insertion into a lumen or cavity, said imaging probe comprising an imaging assembly configured to obtain images according to a first imaging modality and a second imaging modality, wherein said first imaging modality is compatible with a presence of a displaceable medium within the lumen or cavity, and wherein the second imaging modality is different from the first imaging modality; a driver and adapter unit for interfacing with said imaging probe, the driver and adapter unit comprising a mechanism for longitudinal translation of the imaging probe; medium displacement means for effecting a displacement of the displaceable medium within the lumen or cavity; at least one processor interfaceable with said imaging assembly through said driver and adapter unit, wherein said at least one processor is configured to: control said driver and adapter unit to direct a first translation operation of said imaging assembly; during said first translation operation, obtain a first set of images from said imaging assembly according to the first imaging modality; spatially correlate the first set of images with an associated position of said imaging assembly; identify, or receive input identifying, a region of interest within the first set of images; control said driver and adapter unit to direct a second translation operation of said imaging assembly; and; during said second translation operation: obtain a second set of images of the region of interest from said imaging assembly according to the second imaging modality; and direct a medium displacement operation employing said medium displacement means when obtaining the second set of images; and spatially correlate the second set of images with an associated position of said imaging assembly of said imaging probe. an imaging probe configured for insertion into a lumen or cavity, said imaging probe comprising an imaging assembly configured to obtain images according to a first imaging modality and a second imaging modality, wherein said first imaging modality is compatible with a presence of a displaceable medium within the lumen or cavity, and wherein the second imaging modality is different from the first imaging modality; a driver and adapter unit for interfacing with said imaging probe, the driver and adapter unit comprising a mechanism for longitudinal translation of the imaging probe; medium displacement means for effecting a displacement of the displaceable medium within the lumen or cavity; at least one processor interfaceable with said imaging assembly through said driver and adapter unit, wherein said at least one processor is configured to: control said driver and adapter unit to direct a first translation operation of said imaging assembly; during said first translation operation, obtain a first set of images from said imaging assembly according to the first imaging modality; spatially correlate the first set of images with an associated position of said imaging assembly; identify, or receive input identifying, a region of interest within the first set of images; control said driver and adapter unit to direct a second translation operation of said imaging assembly; and; during said second translation operation: obtain a second set of images of the region of interest from said imaging assembly according to the second imaging modality; and direct a medium displacement operation employing said medium displacement means when obtaining the second set of images; and spatially correlate the second set of images with an associated position of said imaging assembly of said imaging probe. control said driver and adapter unit to direct a first translation operation of said imaging assembly; during said first translation operation, obtain a first set of images from said imaging assembly according to the first imaging modality; spatially correlate the first set of images with an associated position of said imaging assembly; identify, or receive input identifying, a region of interest within the first set of images; control said driver and adapter unit to direct a second translation operation of said imaging assembly; and; during said second translation operation: obtain a second set of images of the region of interest from said imaging assembly according to the second imaging modality; and direct a medium displacement operation employing said medium displacement means when obtaining the second set of images; and spatially correlate the second set of images with an associated position of said imaging assembly of said imaging probe. obtain a second set of images of the region of interest from said imaging assembly according to the second imaging modality; and direct a medium displacement operation employing said medium displacement means when obtaining the second set of images; and spatially correlate the second set of images with an associated position of said imaging assembly of said imaging probe.