mhurhangee/ep-ind-claims huggingface dataset:
A method for producing a hepatic precursor-like cell line, comprising: S1: providing human primary hepatocyte cultures, proliferation-and passage-culturing the human primary hepatocyte cultures with a passage ratio of 1:3 to 1:6 and a passage number of 2 to 30 to obtain to-be-infected cultures; S2: confluence-culturing the to-be-infected cultures at a seeding density of 0.5×10 4 -1×10 5 cells/cm 2 to obtain adherent cells, wherein the confluence rate of the adherent cells is not less than 80%; S3: virus-infecting the adherent cells with a lentivirus suspension and a viral infection enhancement buffer using TEM medium, wherein one expressed gene of the lentivirus is SV40 large T antigen, HPV E6E7 gene or human telomerase reverse transcriptase gene (hTERT gene), and the viral infection enhancement buffer is polybrene buffer, and replacing the TEM medium during the virus infection, wherein the amount of the lentivirus in the suspension is 0.5 to 50 times the amount of adherent cells, and the concentration of the virus infection enhancement buffer is 6-12 μg/ml; S4: proliferation-culturing and subculturing the infected cell with a selecting agent and an amplification medium for a proliferation duration of 24-36 hours to obtain immortalized cells with a subculture ratio of 1:3 to 1:6 and a passage number of 10 to 100, wherein the selecting agent is puromycin, hygromycin, or neomycin sulfate and used for selection of the infected cell, and the amplification medium is the TEM medium; and S5: overexpressing FOXA3 in the immortalized cell line to obtain the hepatic precursor-like cell line. S1: providing human primary hepatocyte cultures, proliferation-and passage-culturing the human primary hepatocyte cultures with a passage ratio of 1:3 to 1:6 and a passage number of 2 to 30 to obtain to-be-infected cultures; S2: confluence-culturing the to-be-infected cultures at a seeding density of 0.5×10 4 -1×10 5 cells/cm 2 to obtain adherent cells, wherein the confluence rate of the adherent cells is not less than 80%; S3: virus-infecting the adherent cells with a lentivirus suspension and a viral infection enhancement buffer using TEM medium, wherein one expressed gene of the lentivirus is SV40 large T antigen, HPV E6E7 gene or human telomerase reverse transcriptase gene (hTERT gene), and the viral infection enhancement buffer is polybrene buffer, and replacing the TEM medium during the virus infection, wherein the amount of the lentivirus in the suspension is 0.5 to 50 times the amount of adherent cells, and the concentration of the virus infection enhancement buffer is 6-12 μg/ml; S4: proliferation-culturing and subculturing the infected cell with a selecting agent and an amplification medium for a proliferation duration of 24-36 hours to obtain immortalized cells with a subculture ratio of 1:3 to 1:6 and a passage number of 10 to 100, wherein the selecting agent is puromycin, hygromycin, or neomycin sulfate and used for selection of the infected cell, and the amplification medium is the TEM medium; and S5: overexpressing FOXA3 in the immortalized cell line to obtain the hepatic precursor-like cell line.
A method for manufacturing a multi-ply tissue paper, comprising the steps of: (a) providing a first tissue comprising at least one tissue ply; (b) applying an aqueous, repulpable adhesive composition comprising an alkali soluble acrylic copolymer to the surface area of one face of the first tissue; (c) providing a second tissue comprising at least one tissue ply; (d) laminating the first tissue to the second tissue together by contacting the face of the first tissue provided with the adhesive composition with one face of the second tissue, thereby forming a multi-ply tissue paper, wherein the plies are adhesively bonded to one another; (e) optionally providing the multi-ply tissue paper of step (d) as a first tissue comprising at least one tissue ply and repeating steps (b) to (d), characterised in that the acrylic copolymer is a fully or partially saponified acrylic copolymer. (a) providing a first tissue comprising at least one tissue ply; (b) applying an aqueous, repulpable adhesive composition comprising an alkali soluble acrylic copolymer to the surface area of one face of the first tissue; (c) providing a second tissue comprising at least one tissue ply; (d) laminating the first tissue to the second tissue together by contacting the face of the first tissue provided with the adhesive composition with one face of the second tissue, thereby forming a multi-ply tissue paper, wherein the plies are adhesively bonded to one another; (e) optionally providing the multi-ply tissue paper of step (d) as a first tissue comprising at least one tissue ply and repeating steps (b) to (d),
Bus system comprising a control device, bus lines, bus subscribers, wherein at least one bus subscriber is a distributor, wherein at least one bus subscriber is an actuator, and wherein at least one bus subscriber is a sensor, subbus distributors, a subbus system wherein the bus subscribers of the bus system are connected to the control device via the bus lines, characterized in that the series-connected subbus distributors of the subbus system are in turn connected to the distributor, which each comprise a device for monitoring the supply voltage present at the subbus distributors and connections, wherein the subbus distributors are further provided with a device for outputting a warning message when the supply voltage falls below a minimum.
A method, performed by a processor of a vehicle, of generating current position data of the vehicle, the method comprising the steps of: receiving electronic horizon data indicating possible paths of movement of said vehicle on a road network; receiving sensor data (130a, 130b, 130c) obtained by a plurality of sensors (300a, 300b), and using the sensor data (130a, 130b, 130c) obtained by one of the sensors (300a, 300b) to generate a sensor data path (120a, 120b) which is a position path of the vehicle by calculation from the respective sensor data; and generating a fused position of said vehicle as said current position, based on the received sensor data (130a, 130b, 130c) and the received electronic horizon data; characterized in that said step of generating a fused position includes the steps of comparing each of the sensor data paths (120a, 120b) with the electronic horizon data; judging, for each of the sensor data paths (120a, 120b), whether the respective path and the sensor data indicating the path are reliable, based on the result of the comparing step; selecting the sensor data paths that are judged to be reliable and ignoring the sensor data paths that are not judged to be reliable; and performing a data fusion based on the sensor data indicating the selected sensor data paths. receiving electronic horizon data indicating possible paths of movement of said vehicle on a road network; receiving sensor data (130a, 130b, 130c) obtained by a plurality of sensors (300a, 300b), and using the sensor data (130a, 130b, 130c) obtained by one of the sensors (300a, 300b) to generate a sensor data path (120a, 120b) which is a position path of the vehicle by calculation from the respective sensor data; and generating a fused position of said vehicle as said current position, based on the received sensor data (130a, 130b, 130c) and the received electronic horizon data; characterized in that said step of generating a fused position includes the steps of comparing each of the sensor data paths (120a, 120b) with the electronic horizon data; judging, for each of the sensor data paths (120a, 120b), whether the respective path and the sensor data indicating the path are reliable, based on the result of the comparing step; selecting the sensor data paths that are judged to be reliable and ignoring the sensor data paths that are not judged to be reliable; and performing a data fusion based on the sensor data indicating the selected sensor data paths.
ONCOS-102 oncolytic adenoviral vector of serotype 5 comprising a 24 base pair (bp) deletion in the E1A-gene constant region 2, a deletion in the early 3 region coding for 6.7K and gp19K proteins, a transgene coding for the human granulocyte macrophage colony stimulating factor (GM-CSF) protein inserted to the E3 region, replacing said 6.7K and gp19K, and having a serotype 5 fiber knob replaced by serotype 3 fiber for use in the treatment of human PD-1 inhibitor refractory cancer, wherein the virus vector is administered in combination with pembrolizumab or nivolumab to a patient, wherein the administration comprises first priming with the virus vector followed by administering pembrolizumab or nivolumab, wherein the virus vector administration is conducted through an intratumoral, intrapleural or intraperitoneal injection.
An image forming apparatus comprising: - a cover that can be opened or closed; - a switch (2, 3) that opens or closes in conjunction with opening or closing of the cover; - a load unit that drives the image forming apparatus; - a load power supply device (1, 1a, 1b) that supplies power to the load unit; - a relay (10, 11) that passes power from the load power supply device (1, 1a, 1b) to the load unit by connecting the load power supply device (1, 1a, 1b) to the load unit by connecting the load power supply device (1, 1a, 1b) and the load unit in conjunction with opening or closing of the switch (2, 3); and - a controller (4, 5) that is configured to output a voltage generation signal and to detect opening or closing of the switch (2, 3) and to control the load power supply device (1, 1a, 1b) according to a detection result, wherein when detecting opening of the switch (2, 3), the controller (4, 5) turns off the voltage generation signal, and then controls the load power supply device (1, 1a, 1b) to interrupt supplying power to the load unit until detecting closing of the switch (2, 3), characterized in that the controller (4, 5) further includes a relay driving unit that drives the relay (10, 11), and when the image forming apparatus shifts to an energy-saving mode, the controller (4, 5) controls the relay driving unit to stop driving the relay (10, 11). - a cover that can be opened or closed; - a switch (2, 3) that opens or closes in conjunction with opening or closing of the cover; - a load unit that drives the image forming apparatus; - a load power supply device (1, 1a, 1b) that supplies power to the load unit; - a relay (10, 11) that passes power from the load power supply device (1, 1a, 1b) to the load unit by connecting the load power supply device (1, 1a, 1b) to the load unit by connecting the load power supply device (1, 1a, 1b) and the load unit in conjunction with opening or closing of the switch (2, 3); and - a controller (4, 5) that is configured to output a voltage generation signal and to detect opening or closing of the switch (2, 3) and to control the load power supply device (1, 1a, 1b) according to a detection result, wherein when detecting opening of the switch (2, 3), the controller (4, 5) turns off the voltage generation signal, and then controls the load power supply device (1, 1a, 1b) to interrupt supplying power to the load unit until detecting closing of the switch (2, 3),
A method of mapping electrical activation of tissue, comprising: receiving, at an electroanatomical mapping system, a plurality of electrophysiology data points, each of the plurality of electrophysiology data points including local activation timing information; selecting each of the plurality of electrophysiology data points; and identifying a subset of neighboring electrophysiology data points falling within a preset distance to the selected electrophysiology data point, the electroanatomical mapping system computing a slow conduction metric for the selected electrophysiology data point as one of a weighted variance of the local activation timing information for the subset of the plurality of electrophysiology data points and a weighted standard deviation of the local activation timing information for the subset of the plurality of electrophysiology data points, where weighting is inversely related to distance from the selected electrophysiology data point, thereby creating a slow conduction map. receiving, at an electroanatomical mapping system, a plurality of electrophysiology data points, each of the plurality of electrophysiology data points including local activation timing information; selecting each of the plurality of electrophysiology data points; and identifying a subset of neighboring electrophysiology data points falling within a preset distance to the selected electrophysiology data point, the electroanatomical mapping system computing a slow conduction metric for the selected electrophysiology data point as one of a weighted variance of the local activation timing information for the subset of the plurality of electrophysiology data points and a weighted standard deviation of the local activation timing information for the subset of the plurality of electrophysiology data points, where weighting is inversely related to distance from the selected electrophysiology data point, thereby creating a slow conduction map.
Tensioning device for tensioning traction means of a traction drive, comprising: a base member; a first tensioning arm, pivotably supported on the base member and carrying a first tensioning roller; a second tensioning arm, pivotably supported on the base member and carrying a second tensioning roller; a spring arrangement with a first spring and a second spring, arranged to be effective between the first and the second tensioning arm (4, 6); wherein the two tensioning arms (4, 6), when being pivoted relative to each other within a first tensioning angle range, are force-loaded against each other by the first spring, characterised in that the second spring within the first tensioning angle range is force-free relative to at least one of the two tensioning arms (4, 6); and that the two tensioning arms (4, 6), when being pivoted relative to each other within a second tensioning angle range comprising larger tensioning angles than the first tensioning angle range, are force-loaded against each other by the first spring and additionally by the second spring. a base member; a first tensioning arm, pivotably supported on the base member and carrying a first tensioning roller; a second tensioning arm, pivotably supported on the base member and carrying a second tensioning roller; a spring arrangement with a first spring and a second spring, arranged to be effective between the first and the second tensioning arm (4, 6); wherein the two tensioning arms (4, 6), when being pivoted relative to each other within a first tensioning angle range, are force-loaded against each other by the first spring, characterised in that the second spring within the first tensioning angle range is force-free relative to at least one of the two tensioning arms (4, 6); and that the two tensioning arms (4, 6), when being pivoted relative to each other within a second tensioning angle range comprising larger tensioning angles than the first tensioning angle range, are force-loaded against each other by the first spring and additionally by the second spring.
Method for controlling the stability conditions of a machine moveable on a ground having at least an operational component, in particular a hydraulic cylinder, for moving a portion of the machine, and being maneuvered by an operator through operational commands, the method comprising: acquiring at least a first sensor signal defining the position of the portion of the machine; acquiring at least a second sensor signal defining a variation of the position of the portion of the machine relative to the ground; acquiring at least a command signal defining the operational commands of the operator for actuating the operational component and for transmitting an operational velocity to said portion of the machine; determining a stability condition of the machine based on the first sensor signal, the second sensor signal and the command signal, and outputting a control signal to control the operational component as a function of the determined stability condition, wherein the stability condition is determined by monitoring and estimating both the static and the dynamic stability conditions of the machine, by monitoring and estimating the position of the center of gravity and of an index of stability of the machine, relative to a contact area of the machine with the ground, characterized in that estimating the dynamic stability comprises an acceleration scaling process, the method comprising generating a corrected operational acceleration based on said acceleration scaling process. acquiring at least a first sensor signal defining the position of the portion of the machine; acquiring at least a second sensor signal defining a variation of the position of the portion of the machine relative to the ground; acquiring at least a command signal defining the operational commands of the operator for actuating the operational component and for transmitting an operational velocity to said portion of the machine; determining a stability condition of the machine based on the first sensor signal, the second sensor signal and the command signal, and outputting a control signal to control the operational component as a function of the determined stability condition, wherein the stability condition is determined by monitoring and estimating both the static and the dynamic stability conditions of the machine, by monitoring and estimating the position of the center of gravity and of an index of stability of the machine, relative to a contact area of the machine with the ground, characterized in that estimating the dynamic stability comprises an acceleration scaling process, the method comprising generating a corrected operational acceleration based on said acceleration scaling process.
A method, comprising: accessing a request to rollback one or more changes made to parameters of managed objects associated with a communication network 102 within a given time period; retrieving information identifying the one or more changes made to the parameters of the managed objects within the given time period, wherein retrieving information identifying the one or more changes made to the parameters of the managed objects within the given time period includes calling an application programming interface of a differential service provided by the communication network 102 that maintains a record of changes made to parameters of managed objects associated with the communication network; and for each managed object: determining a cumulative changetype associated with the one or more changes made to the parameters of the managed object; and performing an action to apply the determined cumulative changetype to the managed object; wherein the cumulative changetype is determined by merging all changes made to the managed object within the given time period. accessing a request to rollback one or more changes made to parameters of managed objects associated with a communication network 102 within a given time period; retrieving information identifying the one or more changes made to the parameters of the managed objects within the given time period, wherein retrieving information identifying the one or more changes made to the parameters of the managed objects within the given time period includes calling an application programming interface of a differential service provided by the communication network 102 that maintains a record of changes made to parameters of managed objects associated with the communication network; and for each managed object: determining a cumulative changetype associated with the one or more changes made to the parameters of the managed object; and performing an action to apply the determined cumulative changetype to the managed object; wherein the cumulative changetype is determined by merging all changes made to the managed object within the given time period. determining a cumulative changetype associated with the one or more changes made to the parameters of the managed object; and performing an action to apply the determined cumulative changetype to the managed object; wherein the cumulative changetype is determined by merging all changes made to the managed object within the given time period.
A microstructured optical fibre referred to as MOF comprising a doped core region embedded in a cladding layer, and comprising a plurality of longitudinal tubes, wherein a radial cross-section of the MOF comprises a central hexagonal portion comprising a plurality of holes (4, 5, 7) arranged according to a hexagonal grid surrounding a core section of the core region, each hole (4, 5, 7) corresponding to a respective tube, within a hexagonal boundary of said grid, the plurality of holes (4, 5, 7) comprising holes of a first type and holes of a second type and arranged in a biaxial mirror-symmetric configuration with respect to two perpendicular central axes (Al, All) of the radial cross-section of the MOF, wherein said holes of said first type are arranged in two side holey structures (HS1, HS2) symmetrically arranged with respect to one of the central axis and comprising distinct sub-grids of said hexagonal grid, each of said side holey structures (HS1, HS2) being defined by respective outer boundaries corresponding to portions of said hexagonal boundary of said grid and respective inner boundaries (i1, i2), wherein the holes of the first type have a diameter which is larger than a diameter of the holes of the second type, characterized in that the inner boundaries (i1, i2) of the respective side holey structures (HS1, HS2) are defined by sub-grid positions of holes of the first type along a straight line extending across the centre of the MOF, wherein each side holey structure (HS1, HS2) comprises three grid positions (c3, c4, c5) directly adjacent to the core section, the two outer grid positions (c3, c5) comprising holes (5, 7) of diameter smaller than the diameter of the holes of the first type while the central grid position of the three grid positions comprises a hole of the first type.
A nutritional emulsion comprising fat, carbohydrate, protein, and calcium beta-hydroxy-beta-methylbutyrate wherein a soluble protein represents from 50% to 100% by weight of total protein in the emulsion; and wherein the emulsion comprises from 0.1% to 8% by weight of calcium beta-hydroxy-beta-methylbutyrate.
Lighting module for a vehicle, comprising: - a light source for generating a light beam, - a light-converting device for converting the laser beam into a beam of converted light, - a safety system for monitoring the beam of converted light, the safety system comprising a detecting device placed so as to receive the beam of converted light directly, the detecting device being capable of measuring variations in at least two parameters associated with the beam of converted light and of delivering at least two distinctive information items (A, B) corresponding to the two parameters of the beam of converted light characterized in that a first parameter is an intensity of the beam of converted light for a first wavelength spectrum of the beam of converted light, and a second parameter is an intensity of the beam of converted light for a second wavelength spectrum of the beam of converted light, said second wavelength spectrum being different from the first wavelength spectrum. - a light source for generating a light beam, - a light-converting device for converting the laser beam into a beam of converted light, - a safety system for monitoring the beam of converted light, the safety system comprising a detecting device placed so as to receive the beam of converted light directly,