mhurhangee/ep-ind-claims huggingface dataset:
A method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method comprising the steps of: (a) removing high molecular weight proteins by ammonium sulfate salt precipitation and recovery of antibody or antibody fragment that remains soluble; (b) inducing the formation of immunoglobulin aggregates by addition of a multivalent hapten to said supernatant from (a), wherein said multivalent hapten comprises multiple haptens connected by a linker effective to prevent the binding of the multiple haptens of the multivalent hapten to the same antibody or antibody fragment; (c) dissolving immunoglobulin aggregates recovered from (b) and dissociating them from multivalent hapten by addition of excess monovalent hapten; and (d) separating the dissociated antibodies or antibody fragments from said monovalent and multivalent haptens. (a) removing high molecular weight proteins by ammonium sulfate salt precipitation and recovery of antibody or antibody fragment that remains soluble; (b) inducing the formation of immunoglobulin aggregates by addition of a multivalent hapten to said supernatant from (a), wherein said multivalent hapten comprises multiple haptens connected by a linker effective to prevent the binding of the multiple haptens of the multivalent hapten to the same antibody or antibody fragment; (c) dissolving immunoglobulin aggregates recovered from (b) and dissociating them from multivalent hapten by addition of excess monovalent hapten; and (d) separating the dissociated antibodies or antibody fragments from said monovalent and multivalent haptens.
A method of repairing a shaft, such as a subsea riser, for use in the oil industry, the method comprising: cutting through the shaft at a pre-determined location, resulting in a first shaft section and a second shaft section; attaching a gripper unit apparatus onto the first shaft section, the gripper unit apparatus protruding from the first shaft section; landing an alignment and installation apparatus onto said gripper unit apparatus, the alignment and installation apparatus carrying a component to be installed on the cut end of the first shaft section, wherein the component is a connector for connecting the first shaft section to a flexible pipe; pitching and rotating the alignment and installation apparatus to align an axis of the connector with the axis of the first shaft section; contracting the alignment and installation apparatus, thereby translating the connector substantially along the axis of the first shaft section until the cut end of the first shaft section is positioned on or within the connector; and activating the connector to secure it onto the first shaft section, thereby enabling the communication of fluids between the flexible pipe and the first shaft section. cutting through the shaft at a pre-determined location, resulting in a first shaft section and a second shaft section; attaching a gripper unit apparatus onto the first shaft section, the gripper unit apparatus protruding from the first shaft section; landing an alignment and installation apparatus onto said gripper unit apparatus, the alignment and installation apparatus carrying a component to be installed on the cut end of the first shaft section, wherein the component is a connector for connecting the first shaft section to a flexible pipe; pitching and rotating the alignment and installation apparatus to align an axis of the connector with the axis of the first shaft section; contracting the alignment and installation apparatus, thereby translating the connector substantially along the axis of the first shaft section until the cut end of the first shaft section is positioned on or within the connector; and activating the connector to secure it onto the first shaft section, thereby enabling the communication of fluids between the flexible pipe and the first shaft section.
Filter device with a plurality of filter elements, which can be received in a filter housing with a filter inlet for fluid to be filtered and a filter outlet for the filtered fluid, at least one of the filter elements being able to be backwashed during operation of the device to clean its active filter surface by means of a backwashing apparatus, which contains a pressure control apparatus to support backwashing, the filter elements each being received in an element housing, said element housing, with the filter elements performing the filtration operation, being connected by their one open end in a fluid-conveying manner to the filter outlet, the element housing of each filter element that can be backwashed being connected by its open end exclusively to the pressure control apparatus, characterised in that all filter elements with their element housings are mounted on their ends in rotary receptacles in a filtrate chamber, said receptacles being able to be moved from a filtration position into a backwashing position and back into a filtration position by means of a rotary drive, in that a partition wall is drawn in the filter housing between the pressure control apparatus and the filtrate chamber with the rotary receptacles, said wall comprising a passage, with which the filter element provided for a backwashing operation is aligned, and in that the pressure control apparatus comprises a storage part with a pressure chamber that can be filled with a working gas and a fluid chamber that receives a backwashing volume.
A method for preparing a tissue sample for confocal laser scanning microscopy, comprising the following steps: 1.) providing a tissue sample (13, 13', 13") 2.) if necessary, cutting of the tissue sample (13, 13', 13") 3.) Applying the tissue sample to a object slide (18; 34) 4.) Applying a cover (22; 42) over the tissue sample (13, 13', 13"), wherein the cover (22; 42) is connected to the slide (18; 34) by means of a hardenable, plastically deformable mass, 5.) pressing the cover (22; 42) onto the tissue sample (13, 13', 13") with a predetermined force, and 6.) Hardening of the plastically deformable mass, while maintaining the pressure of step 5, wherein the hardenable, plastically deformable mass is selected from the hardenable silicones and the hardenable polyethers, in particular selected from the A-silicones and the K-silicones. 1.) providing a tissue sample (13, 13', 13") 2.) if necessary, cutting of the tissue sample (13, 13', 13") 3.) Applying the tissue sample to a object slide (18; 34) 4.) Applying a cover (22; 42) over the tissue sample (13, 13', 13"), wherein the cover (22; 42) is connected to the slide (18; 34) by means of a hardenable, plastically deformable mass, 5.) pressing the cover (22; 42) onto the tissue sample (13, 13', 13") with a predetermined force, and 6.) Hardening of the plastically deformable mass, while maintaining the pressure of step 5,
A replaceable cartridge configured for being detachably connected to ar aerosol-generating device comprising: a liquid storage portion for storing a liquid agent, the liquid storage portion comprising a liquid outlet for directing the liquid agent out of the liquid storage portion, a slidable sealing element for sealing the liquid outlet, the slidable sealing element being configured to slide away from the liquid outlet upon application of a pressure to the sealing element, a wicking element arranged adjacent to the liquid outlet for absorbing and supplying the liquid agent to the liquid outlet. a liquid storage portion for storing a liquid agent, the liquid storage portion comprising a liquid outlet for directing the liquid agent out of the liquid storage portion, a slidable sealing element for sealing the liquid outlet, the slidable sealing element being configured to slide away from the liquid outlet upon application of a pressure to the sealing element, a wicking element arranged adjacent to the liquid outlet for absorbing and supplying the liquid agent to the liquid outlet.
Method for detecting liquids using a system for the optical verification of liquids, wherein the system comprises an insert part with two contiguous layers (1, 2), wherein the first layer and the second layer are substantially optically separated and only optically coupled in the measurement region, wherein at least one microfluidic structure for passing liquids is situated in the measurement region, wherein a light beam is able to be input coupled into the first layer and wherein the second layer is transparent to the input-coupled light beam, characterized in that the microfluidic structure in the measurement region is filled with a first medium in the first layer, said medium having a refractive index at which the conditions for total-internal reflection are satisfied in the first layer and wherein, then, the microfluidic structure is filled with a second medium and wherein the refractive index in the measurement region changes on account of the arriving second medium such that the conditions for total-internal reflection are no longer satisfied and the light beam is guided into the second layer and this deflection of the light beam is measured by the detector and the arrival of the liquid front in the measurement region is determined thereby.
Sealing assembly for bearings, in particular for use in agriculture, the sealing assembly being suitable to be arranged in a bearing unit provided with an outer ring and with an inner ring (16b, 25) that define a gap, and prevents the ingress of contaminants into the bearing unit through the gap and comprising a first shield, which extends from an outer surface of the inner ring (16b, 25) to an inner surface of the outer ring, and is mounted on the outer surface of the inner ring (16b, 25), and a seal with a plurality of contact lips supported by the first shield, and comprising a predetermined number of contact lips arranged in series axially next to one another; wherein the contact lips lie, when in a respective pre-assembly configuration, in respective planes that are inclined with respect to a central axis of the bearing, the sealing assembly being characterized in that the lips have radial heights decreasing axially towards the bearing; the contact lips starting from a common base made of the same material as the lips, that is rigidly secured to a cylindrical support body of the first screen, and the gradual reduction in radial height of the contact lips is obtained by means of a gradual axial increase in a radial thickness of the relative base.
Method for welding a base material made of fully austenitic, nitrogen-alloyed chromium-nickel steel using a welding filler, characterised in that the base material is UNS S20910 and the welding filler is a combination of 51% 1.4452 and 49% 2.4659 in weight percent.
An ADSL modem comprising: memory adapted to store a plurality of PRBS generator definitions used for training of the ADSL modem; and circuitry adapted to determine an operating environment of the modem, wherein the operating environment of the ADSL modem comprises at least one channel condition; and to select one of the plurality of PRBS generator definitions based on the operating environment, wherein the PRBS generator is a shift register based PRBS generator, defined by a set of coefficients having the general form {c N, c N-1,..., c 1}, the PRBS generator having a length N exceeding 9, wherein the modem is adapted to transmit an indication of the selected PRBS generator definition to a remote communication device to inform the remote communication device of the selection. memory adapted to store a plurality of PRBS generator definitions used for training of the ADSL modem; and circuitry adapted to determine an operating environment of the modem, wherein the operating environment of the ADSL modem comprises at least one channel condition; and to select one of the plurality of PRBS generator definitions based on the operating environment, wherein the PRBS generator is a shift register based PRBS generator, defined by a set of coefficients having the general form {c N, c N-1,..., c 1}, the PRBS generator having a length N exceeding 9, wherein the modem is adapted to transmit an indication of the selected PRBS generator definition to a remote communication device to inform the remote communication device of the selection.
A storage warehouse configured to store a first article and a second article, the second article having a shape or size different from that of the first article and being transported while placed on an attachment, the storage warehouse comprising: the attachment; a storage part including a shelf (32, 33) whereon the first article or the second article in a state in which it is placed on the attachment are placeable; a port (11, 12) whereon the first article or the second article in the state in which it is placed on the attachment is placed in order to enter the first article or the second article in the state in which it is placed on the attachment into the storage part and/or in order to remove the first article or the second article in the state in which it is placed on the attachment from the storage part; a transport apparatus (13, 14) configured to transport the first article or the second article in the state in which it is placed on the attachment between the storage part and the port (11, 12); a buffer part configured to temporarily store the attachment; and a transfer apparatus configured to transfer the attachment between the buffer part and the port (11, 12). the attachment; a storage part including a shelf (32, 33) whereon the first article or the second article in a state in which it is placed on the attachment are placeable; a port (11, 12) whereon the first article or the second article in the state in which it is placed on the attachment is placed in order to enter the first article or the second article in the state in which it is placed on the attachment into the storage part and/or in order to remove the first article or the second article in the state in which it is placed on the attachment from the storage part; a transport apparatus (13, 14) configured to transport the first article or the second article in the state in which it is placed on the attachment between the storage part and the port (11, 12); a buffer part configured to temporarily store the attachment; and a transfer apparatus configured to transfer the attachment between the buffer part and the port (11, 12).
A method for efficient matching for content-based addressing, the method comprising: accepting, at a receiver machine, a first query from a query application, wherein the first query comprises one or more fields and one or more values, wherein the one or more fields are associated with a category of content, and wherein the one or more values are associated with a particular type of content; generating, at the receiver machine, a tree structure ordered by the one or more fields of the first query, wherein the tree structure comprises one or more tree nodes and the one or more tree nodes comprise one or more query nodes and wherein each of the query nodes comprises at least one field and at least one value associated with the first query; analyzing, at the receiver machine, a message from a sender machine, wherein the message comprises a content field associated with a content value; searching, by the receiver machine, the tree structure using the content field of the message; determining, by the receiver machine, if the content value of the message matches a content value of the first query stored in the tree structure; and accepting, by the receiver machine, the message if the content value of the message matches one or more content values of the first query. accepting, at a receiver machine, a first query from a query application, wherein the first query comprises one or more fields and one or more values, wherein the one or more fields are associated with a category of content, and wherein the one or more values are associated with a particular type of content; generating, at the receiver machine, a tree structure ordered by the one or more fields of the first query, wherein the tree structure comprises one or more tree nodes and the one or more tree nodes comprise one or more query nodes and wherein each of the query nodes comprises at least one field and at least one value associated with the first query; analyzing, at the receiver machine, a message from a sender machine, wherein the message comprises a content field associated with a content value; searching, by the receiver machine, the tree structure using the content field of the message; determining, by the receiver machine, if the content value of the message matches a content value of the first query stored in the tree structure; and accepting, by the receiver machine, the message if the content value of the message matches one or more content values of the first query.
A food mixer cleaning apparatus for cleaning the interior of a food mixing bowl of a food mixer comprising: a support structure (2, 3) for attachment to or attached to the exterior of a food mixer, an arm movably carried by said support structure, a cleaning lance carried by said arm, a spray nozzle assembly at an end of the lance, and a pump operable to deliver cleaning fluid under pressure over a conduit to the lance and spray nozzle assembly, characterized in that it comprises an actuator operable to reciprocally move the arm on the support structure (2, 3) to insert or retract the lance into or out of a food mixing bowl through an aperture, and in that it comprises a flap and associated actuator to normally close the aperture when the cleaning lance is retracted, the associated actuator being operable to open the flap to allow insertion and retraction of the lance into and from the bowl through said aperture. a support structure (2, 3) for attachment to or attached to the exterior of a food mixer, an arm movably carried by said support structure, a cleaning lance carried by said arm, a spray nozzle assembly at an end of the lance, and a pump operable to deliver cleaning fluid under pressure over a conduit to the lance and spray nozzle assembly, characterized in that it comprises an actuator operable to reciprocally move the arm on the support structure (2, 3) to insert or retract the lance into or out of a food mixing bowl through an aperture, and in that it comprises a flap and associated actuator to normally close the aperture when the cleaning lance is retracted, the associated actuator being operable to open the flap to allow insertion and retraction of the lance into and from the bowl through said aperture.
Apparatus for removing solid material from liquid comprising: a pair of chains, each forming a continuous loop; a plurality of step-shaped filter units each comprising a riser plate and a tread plate, each filter unit mounted between the chains, by rotatable mounts allowing rotation about an axis along the edge of the riser plate opposite to the tread plate; a drive mechanism to convey the filter units around the loop; a guide track that engages with the filter units to guide the rotation of each filter unit, such that in use, each filter unit sequentially transitions between presenting a stepped profile and a smooth profile on the outside of the loop. a pair of chains, each forming a continuous loop; a plurality of step-shaped filter units each comprising a riser plate and a tread plate, each filter unit mounted between the chains, by rotatable mounts allowing rotation about an axis along the edge of the riser plate opposite to the tread plate; a drive mechanism to convey the filter units around the loop; a guide track that engages with the filter units to guide the rotation of each filter unit, such that in use, each filter unit sequentially transitions between presenting a stepped profile and a smooth profile on the outside of the loop.
Crankshaft for a controlled variable compression ratio engine, comprising an axis of rotation which defines a longitudinal axis (y) and comprising at least one crank pin, at least one journal connected by a connecting arm, and at least one control element which is capable of translationally moving along the longitudinal axis (y) in order to engage with an actuator of a system for adjusting the length of a connecting rod, the crankshaft being characterized in that: • the control element, which is arranged at the connecting arm, comprises an annular portion which is coaxial with the crank pin and capable of establishing continuous contact with the actuator of the system for adjusting the length of the connecting rod, regardless of the angular position of the crankshaft, • the crankshaft comprises a fluid control circuit for moving the control element along the longitudinal axis (y). • the control element, which is arranged at the connecting arm, comprises an annular portion which is coaxial with the crank pin and capable of establishing continuous contact with the actuator of the system for adjusting the length of the connecting rod, regardless of the angular position of the crankshaft, • the crankshaft comprises a fluid control circuit for moving the control element along the longitudinal axis (y).
A core-sheath filament comprising: a) 90 to 99.9 weight percent of a core that is a thermally conductive pressure-sensitive adhesive, the core comprising 1) 2 to 50 weight percent of a (meth)acrylate-based polymeric material based on a total weight of the core; and 2) 50 to 98 weight percent of thermally conductive particles based on a total weight of the core; and b) 0.1 to 10 weight percent of a sheath surrounding the core, wherein the sheath comprises a thermoplastic material that is non-tacky; wherein the core-sheath filament has a diameter in a range of 1 to 20 millimeters. a) 90 to 99.9 weight percent of a core that is a thermally conductive pressure-sensitive adhesive, the core comprising 1) 2 to 50 weight percent of a (meth)acrylate-based polymeric material based on a total weight of the core; and 2) 50 to 98 weight percent of thermally conductive particles based on a total weight of the core; and 1) 2 to 50 weight percent of a (meth)acrylate-based polymeric material based on a total weight of the core; and 2) 50 to 98 weight percent of thermally conductive particles based on a total weight of the core; and b) 0.1 to 10 weight percent of a sheath surrounding the core, wherein the sheath comprises a thermoplastic material that is non-tacky;
A compound of formula -4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)- cyclopropyl)benzoic acid or a pharmaceutically acceptable salt thereof for use in the prevention of heterotopic ossification.
An oral cleaning device comprising: a body portion; a brush head member extending from the body portion, the head comprising a bristle face, wherein the bristle face is configured to move relative to the body portion; a master clock; a sensor in communication with the master clock, wherein the sensor is configured to sample sensor data at a sensor sampling frequency, the sampling frequency based on input from the master clock; a second clock; and a drivetrain in communication with the second clock, wherein the drivetrain is configured to generate movement of the bristle face at a first drivetrain frequency, the first drivetrain frequency based on input from the second clock; wherein the sampling frequency and the first drivetrain frequency are coordinated to minimize drivetrain interference of the sensor. a body portion; a brush head member extending from the body portion, the head comprising a bristle face, wherein the bristle face is configured to move relative to the body portion; a master clock; a sensor in communication with the master clock, wherein the sensor is configured to sample sensor data at a sensor sampling frequency, the sampling frequency based on input from the master clock; a second clock; and a drivetrain in communication with the second clock, wherein the drivetrain is configured to generate movement of the bristle face at a first drivetrain frequency, the first drivetrain frequency based on input from the second clock; wherein the sampling frequency and the first drivetrain frequency are coordinated to minimize drivetrain interference of the sensor.