mhurhangee/ep-ind-claims huggingface dataset:
A robotic apparatus comprising: a main bed fitted with an imaging station where a sample container containing a sample of one or more cells or cell colonies can be placed in an object position; a head with associated positioning system mounted above the main bed of the apparatus; excitation and collection optical sub-systems mounted under the main bed of the apparatus and arranged to excite, and collect light from, the object position from below so as to make a spectroscopic measurement on the cell or cell colonies; spectroscopic analysis means operable to analyse the spectroscopic measurement and select one or more of the cells or cell colonies for picking based on their spectroscopic properties; wherein the head is a cell picking head comprising at least one pin controllable by a controller to pick the selected one or ones of the cells or cell colonies; the robotic apparatus being characterized in that the excitation optical sub-system comprises a plurality of different types of optical source of different emission wavelengths for selectively exciting a plurality of different dyes of interest; and the excitation optical sub-system further comprises at least one white light source arranged to illuminate the object position at an oblique angle, and wherein the collection optical sub-system is arranged to collect light from the object position such that light from said at least one white light source is collected in a dark field configuration where light from the at least one white light source, if not scattered, does not contribute to the collected signal. a main bed fitted with an imaging station where a sample container containing a sample of one or more cells or cell colonies can be placed in an object position; a head with associated positioning system mounted above the main bed of the apparatus; excitation and collection optical sub-systems mounted under the main bed of the apparatus and arranged to excite, and collect light from, the object position from below so as to make a spectroscopic measurement on the cell or cell colonies; spectroscopic analysis means operable to analyse the spectroscopic measurement and select one or more of the cells or cell colonies for picking based on their spectroscopic properties; wherein the head is a cell picking head comprising at least one pin controllable by a controller to pick the selected one or ones of the cells or cell colonies; the robotic apparatus being characterized in that the excitation optical sub-system comprises a plurality of different types of optical source of different emission wavelengths for selectively exciting a plurality of different dyes of interest; and the excitation optical sub-system further comprises at least one white light source arranged to illuminate the object position at an oblique angle, and wherein the collection optical sub-system is arranged to collect light from the object position such that light from said at least one white light source is collected in a dark field configuration where light from the at least one white light source, if not scattered, does not contribute to the collected signal.
A shaft-hub connection, wherein a shaft, in particular motor shaft, is introduced into a receiving region of a hub, in particular adapter shaft, and is connected in non-positive manner, in particular connected by clamping, characterised in that the hub, at least in an axial region, has three flattened portions, spaced apart regularly from each other in the circumferential direction, wherein a first screwing part is screwed into a clamping ring (2, 73) and presses on a region of the hub in order to bring about the non-positive connection, wherein the region in the circumferential direction is arranged centrally between two of the flattened portions.
A method for bonding of a first contact surface of a first substrate to a second contact surface of a second substrate with the following sequence: - forming at least one reservoir (5, 5') in at least one reservoir formation layer (6, 6') on the first substrate and/or the second substrate, the reservoir (5, 5') consisting especially at least largely of an amorphous material, and wherein the forming of the at least one reservoir (5, 5') as reservoir formation layer (6, 6') is made by use of a tetraethoxysilane-oxide layer - at least partial filling of the reservoir/reservoirs (5, 5') with a first educt or a first group of educts, - forming or applying a reaction layer which contains a second educt or a second group of educts to the reservoirs (5, 5'), - bringing the first contact surface in contact with the second contact surface for formation of a prebond connection, - forming a permanent bond between the first and second contact surface (3, 4), at least partially strengthened by the reaction of the first educt or the first group with the second educt or the second group. - forming at least one reservoir (5, 5') in at least one reservoir formation layer (6, 6') on the first substrate and/or the second substrate, the reservoir (5, 5') consisting especially at least largely of an amorphous material, and wherein the forming of the at least one reservoir (5, 5') as reservoir formation layer (6, 6') is made by use of a tetraethoxysilane-oxide layer - at least partial filling of the reservoir/reservoirs (5, 5') with a first educt or a first group of educts, - forming or applying a reaction layer which contains a second educt or a second group of educts to the reservoirs (5, 5'), - bringing the first contact surface in contact with the second contact surface for formation of a prebond connection, - forming a permanent bond between the first and second contact surface (3, 4), at least partially strengthened by the reaction of the first educt or the first group with the second educt or the second group.
A device comprising - one or more moveable components and - either an automatically resetting apparatus configured to trap a target creature or an apparatus configured to automatically dispense a substance to a target creature and - an automatic test activation system configured to automatically initiate a periodic test activation of the device, wherein - the automatic test activation system comprises: - an electric power supply; and - and an electronic control system powered by the electric power supply, the device being characterized in that - the electronic control system is configured to automatically activate the device to test the operation of the one or more moveable components, by activating these moveable components and wherein the electronic control system is configured to automatically activate the device periodically based on output from a timer or programmed instructions or both. - one or more moveable components and - either an automatically resetting apparatus configured to trap a target creature or an apparatus configured to automatically dispense a substance to a target creature and - an automatic test activation system configured to automatically initiate a periodic test activation of the device, wherein - the automatic test activation system comprises: - an electric power supply; and - and an electronic control system powered by the electric power supply, the device being characterized in that - the electronic control system is configured to automatically activate the device to test the operation of the one or more moveable components, by activating these moveable components
A method of manufacturing fibre-reinforced blades for wind power plants whereby a number of mats of material comprising fibre are arranged on a curved surface of an elongated open mould, so that some of the mats of material overlap at least partially, wherein each mat of material is positioned on the mould by means of a number of rollers provided on a cart being conveyed along the open mould, whereby at least some of the rollers are displaced mutually during the conveyance of the cart so that the rollers substantially follow an intended contour of the mat of material, wherein said material comprising fibre is unrolled from one or more rolls comprising material, and wherein said rolls comprising material are conveyed along said mould, alternatively said material comprising fibre is unrolled from one or more rolls comprising material by means of an unrolling arrangement drawing said material from said one or more rolls comprising material, and wherein one or more rolls comprising material and said rollers are at least partially accommodated by a dispenser suspended from an arm of said cart, wherein the dispenser is rotationally connected to the arm via pivot, such that said material is arranged on said mould simultaneously with said material being unrolled from said one or more rolls comprising material, and wherein said dispenser is pivoted about the pivot during conveyance, such that said rolls comprising material, and said rollers assumes different angular orientations, wherein an axis of the pivot is oriented substantially in a longitudinal axis of the mould and/or substantially parallel to a direction of conveyance of the cart.
A dispense volume sensor comprising: a dispense needle for dispensing a liquid sample; and a receiving cylinder (5,15) for receiving the dispense needle; wherein a capacitor (Cs) is formed upon receipt of the dispense needle by the receiving cylinder, characterized in that a plurality of dispense needles is arranged in an array of at least one row and at least one column held in place by a first electrical insulating member, a plurality of receiving cylinders (5, 15) is arranged in a matching array of at least one row and at least one column and supported by a second electrical insulating member, such that with an insertion of said plurality of dispense needles a certain distance into said plurality of receiving cylinders a plurality of capacitors (Cs) are formed and arranged to detect amounts of liquid located on the outside of the respective dispense needles after liquid has been aspirated into, or dispensed from, the respective dispense needles. a dispense needle for dispensing a liquid sample; and a receiving cylinder (5,15) for receiving the dispense needle; wherein a capacitor (Cs) is formed upon receipt of the dispense needle by the receiving cylinder, characterized in that a plurality of dispense needles is arranged in an array of at least one row and at least one column held in place by a first electrical insulating member, a plurality of receiving cylinders (5, 15) is arranged in a matching array of at least one row and at least one column and supported by a second electrical insulating member, such that with an insertion of said plurality of dispense needles a certain distance into said plurality of receiving cylinders a plurality of capacitors (Cs) are formed and arranged to detect amounts of liquid located on the outside of the respective dispense needles after liquid has been aspirated into, or dispensed from, the respective dispense needles.
A method for manufacturing a ready-to-use peptide emulsion on the industrial scale, comprising the step of emulsifying a suspension of at least two peptides under low shear conditions, at a rotation speed of between 100 and 1000 rpm, during 2 to 20 minutes, with at least one adjuvant, wherein the method does not comprise any mixing step at high speed, particularly above 7000 rpm.
A 2,2'-bibenzo[d]imidazolidene compound expressed by the following general formula: wherein Ar 1 to Ar 4 each represent substituted or unsubstituted condensed rings, and R 1 to R 8 each represent a hydrogen atom or a substituent selected from the group consisting of halogen atoms, alkyl groups having a carbon number in the range of 1 to 8, and substituted or unsubstituted aromatic hydrocarbon groups.
Canvas cover of a commercial vehicle, in particular a truck, trailer or semitrailer, having at least one side wall canvas and a rear wall, wherein at least one connecting means for fixing the side wall canvas is provided on the rear-facing side of the rear wall and wherein the back end of the side wall canvas is fixed to the rear-facing side of the rear wall on the at least one connecting means of the rear wall, characterised in that the rear wall has at least one swing door opening to the side and in that the at least one connecting means is provided on the rear-facing side of the swing door in the closed position of the swing door.
A method of providing digital map information comprising: providing a map database comprising a plurality of first map elements relating to a first temporal period, each of said plurality of first map elements comprising first attribute information; providing a plurality of second map elements relating to a second different temporal period, each of said plurality of second map elements comprising second attribute information, and each of said second map elements being paired to one of said first map elements; and allowing an alternate selection of said first map elements or said second map elements by providing a switch setting controlling a choice between said first map elements or said second map elements. providing a map database comprising a plurality of first map elements relating to a first temporal period, each of said plurality of first map elements comprising first attribute information; providing a plurality of second map elements relating to a second different temporal period, each of said plurality of second map elements comprising second attribute information, and each of said second map elements being paired to one of said first map elements; and allowing an alternate selection of said first map elements or said second map elements by providing a switch setting controlling a choice between said first map elements or said second map elements.
A drawing method used when performing drawing on a thermal recording medium that includes, above a recording layer, a light-transmitting member having an uneven shape in a plane, the drawing method comprising: providing, on the light-transmitting member, an optical compensator having one surface and another surface to cause the one surface and the light-transmitting member to face each other, the one surface having a shape that fits the uneven shape of the light-transmitting member and the other surface being flat and opposed to the one surface; and irradiating the thermal recording medium with a laser beam via the optical compensator. providing, on the light-transmitting member, an optical compensator having one surface and another surface to cause the one surface and the light-transmitting member to face each other, the one surface having a shape that fits the uneven shape of the light-transmitting member and the other surface being flat and opposed to the one surface; and irradiating the thermal recording medium with a laser beam via the optical compensator.
An antenna unit, comprising: an antenna; at least one radio unit; and at least one interconnect including first and second mating connectors (120, 122), said first connector being configured to be electrically and mechanically coupled to said antenna and said second connector being configured to be electrically and mechanically coupled to said at least one radio unit, wherein said first connector having radial and axial float for blind mating of said first and second mating connectors (120, 122), characterised in that said first connector includes a mounting body, a housing, and a shroud, said mounting body mounts said first connector to said antenna, said shroud surrounds a mating interface of said housing, and a space between said shroud and said mounting body providing the radial float,and in that said mounting body and said shroud are each formed of a dielectric material. an antenna; at least one radio unit; and at least one interconnect including first and second mating connectors (120, 122), said first connector being configured to be electrically and mechanically coupled to said antenna and said second connector being configured to be electrically and mechanically coupled to said at least one radio unit,
A control device of an engine, the engine including: a piston which is contained in a cylinder; an intake passage which is communicated to a combustion chamber of the cylinder; an exhaust passage which is led from the combustion chamber; a fuel injection valve which is configured to inject fuel to the combustion chamber or the intake passage; and an ignition unit which is provided in the combustion chamber, the control device comprising: a low speed pre-ignition predicting unit which is configured to perform prediction of occurrence of low speed pre-ignition, based on operation condition of the engine; a lubricating oil injection controlling unit which is configured to control a lubricating oil injecting device to inject lubricating oil to the piston or a member located around the piston, based on the prediction of the occurrence of the low speed pre-ignition performed by the low speed pre-ignition predicting unit; and a self ignition index calculating unit which is configured to calculate self ignition index which indicates possibility of occurring self ignition of the fuel at a crank angle before an ignition time during a compression stroke, based on temperature and pressure inside the combustion chamber, wherein the low speed pre-ignition predicting unit is configured to perform the prediction of the occurrence of the low speed pre-ignition, based on the self ignition index calculated by the self ignition index calculating unit, characterized in that an injecting direction of the lubricating oil based on the self ignition index is different from an injecting direction of lubricating oil based on a control index for restraining an ordinary pre-ignition, the control index being other than the self ignition index. a low speed pre-ignition predicting unit which is configured to perform prediction of occurrence of low speed pre-ignition, based on operation condition of the engine; a lubricating oil injection controlling unit which is configured to control a lubricating oil injecting device to inject lubricating oil to the piston or a member located around the piston, based on the prediction of the occurrence of the low speed pre-ignition performed by the low speed pre-ignition predicting unit; and a self ignition index calculating unit which is configured to calculate self ignition index which indicates possibility of occurring self ignition of the fuel at a crank angle before an ignition time during a compression stroke, based on temperature and pressure inside the combustion chamber, wherein the low speed pre-ignition predicting unit is configured to perform the prediction of the occurrence of the low speed pre-ignition, based on the self ignition index calculated by the self ignition index calculating unit, characterized in that an injecting direction of the lubricating oil based on the self ignition index is different from an injecting direction of lubricating oil based on a control index for restraining an ordinary pre-ignition, the control index being other than the self ignition index.
A vaporizer device, comprising: a shell; a cartridge receptacle formed from a cartridge interface disposed at least partially inside a sheath, the cartridge interface being configured to provide a plurality of electrical couplings with a vaporizer cartridge when the vaporizer cartridge is disposed at least partially inside the cartridge receptacle, the plurality of electrical couplings including a first electrical coupling with a heating element of the vaporizer cartridge, and the plurality of electrical couplings further including a second electrical coupling with a cartridge identification chip of the vaporizer cartridge; and a skeleton coupled with the cartridge interface, the skeleton being configured to secure the cartridge interface inside the shell, wherein the cartridge interface includes a set of receptacle contacts configured to form the first electrical coupling with a set of heater contacts of the heating element of the vaporizer cartridge, wherein the cartridge interface further includes a set of cartridge identifier contacts configured to form the second electrical coupling with a corresponding set of cartridge identifier contacts at the cartridge identification chip of the vaporizer device, and characterized in that the set of cartridge identifier contacts includes a first set of three electrical contacts disposed at one side of the cartridge receptacle and a second set of three electrical contacts disposed at an opposite side of the cartridge receptacle. a shell; a cartridge receptacle formed from a cartridge interface disposed at least partially inside a sheath, the cartridge interface being configured to provide a plurality of electrical couplings with a vaporizer cartridge when the vaporizer cartridge is disposed at least partially inside the cartridge receptacle, the plurality of electrical couplings including a first electrical coupling with a heating element of the vaporizer cartridge, and the plurality of electrical couplings further including a second electrical coupling with a cartridge identification chip of the vaporizer cartridge; and a skeleton coupled with the cartridge interface, the skeleton being configured to secure the cartridge interface inside the shell, wherein the cartridge interface includes a set of receptacle contacts configured to form the first electrical coupling with a set of heater contacts of the heating element of the vaporizer cartridge, wherein the cartridge interface further includes a set of cartridge identifier contacts configured to form the second electrical coupling with a corresponding set of cartridge identifier contacts at the cartridge identification chip of the vaporizer device, and characterized in that the set of cartridge identifier contacts includes a first set of three electrical contacts disposed at one side of the cartridge receptacle and a second set of three electrical contacts disposed at an opposite side of the cartridge receptacle.
A conveying apparatus comprising a moving, planar conveying means for conveying bulk material or individual entities, for example material or entities which is/are at rest or which can move of their own accord, in particular people or other living things, or for people or animals to walk or run on, wherein the conveying means has arranged beneath it a supporting device, which comprises a roller body with a multiplicity of rollers, wherein the roller body, on one side, has the rollers rolling along a non-circular path on the supporting body and, on the other side, supports the conveying means by the rollers rolling on the conveying means itself or on a belt which runs along between the conveying means and rollers, characterized in that the rollers are connected to one another, and spaced apart from one another, by a flexible connecting body, wherein the connecting body is planar, and the rollers are inserted in openings of the connecting body.
The combination of a MEK inhibitor comprising [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[ -piperidin-2-yl]azetidin-1-yl}methanone (cobimetinib), or a pharmaceutically acceptable salt thereof, and a selective Bcl-2 inhibitor comprising 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (ABT-199), or a pharmaceutically acceptable salt thereof, for use in a method of treating a proliferative disorder, the method comprising administering to a mammal in need thereof a therapeutically effective amount of the combination of the MEK inhibitor and the selective Bcl-2 inhibitor.