A lead system comprising: a cuff electrode (64, 160, 1600) configured to be secured to a nerve of a patient, wherein the cuff electrode comprises: an electrode and a cuff body having an inner surface configured to wrap around the nerve of the patient, the cuff body having a central portion supporting the electrode to face the nerve from the inner surface at the central portion, the cuff body also having a first side and a second side each extending from the central portion in opposing circumferential directions to surround the nerve of the patient, wherein the first side has an narrower width than the second side, wherein the first side extends for a first circumferential distance and the second side extends for a second circumferential direction, and wherein the first circumferential distance is longer than the second circumferential distance, and wherein the first side is configured to overwrap at least a portion of the second side; a first lead portion (62, 2664) extending from the central portion of the cuff electrode (64, 160, 1600) and having a distal end coupled to the cuff electrode (64, 160, 1600), the first lead portion (62, 2664) including a first flexible undulation disposed proximally of the distal end; a second lead portion having a second flexible undulation, wherein an entirety of the second flexible undulation is disposed proximally of an entirety of the first flexible undulation; and an anchor interposed between the first lead portion (62, 2664) and the second lead portion and configured to be secured relative to a non-nerve body structure; wherein a proximal end of the second lead portion is configured to be operably coupled to an implantable pulse generator. a cuff electrode (64, 160, 1600) configured to be secured to a nerve of a patient, wherein the cuff electrode comprises: an electrode and a cuff body having an inner surface configured to wrap around the nerve of the patient, the cuff body having a central portion supporting the electrode to face the nerve from the inner surface at the central portion, the cuff body also having a first side and a second side each extending from the central portion in opposing circumferential directions to surround the nerve of the patient, wherein the first side has an narrower width than the second side, wherein the first side extends for a first circumferential distance and the second side extends for a second circumferential direction, and wherein the first circumferential distance is longer than the second circumferential distance, and wherein the first side is configured to overwrap at least a portion of the second side; a first lead portion (62, 2664) extending from the central portion of the cuff electrode (64, 160, 1600) and having a distal end coupled to the cuff electrode (64, 160, 1600), the first lead portion (62, 2664) including a first flexible undulation disposed proximally of the distal end; an electrode and a cuff body having an inner surface configured to wrap around the nerve of the patient, the cuff body having a central portion supporting the electrode to face the nerve from the inner surface at the central portion, the cuff body also having a first side and a second side each extending from the central portion in opposing circumferential directions to surround the nerve of the patient, wherein the first side has an narrower width than the second side, wherein the first side extends for a first circumferential distance and the second side extends for a second circumferential direction, and wherein the first circumferential distance is longer than the second circumferential distance, and wherein the first side is configured to overwrap at least a portion of the second side; a first lead portion (62, 2664) extending from the central portion of the cuff electrode (64, 160, 1600) and having a distal end coupled to the cuff electrode (64, 160, 1600), the first lead portion (62, 2664) including a first flexible undulation disposed proximally of the distal end; a second lead portion having a second flexible undulation, wherein an entirety of the second flexible undulation is disposed proximally of an entirety of the first flexible undulation; and an anchor interposed between the first lead portion (62, 2664) and the second lead portion and configured to be secured relative to a non-nerve body structure; wherein a proximal end of the second lead portion is configured to be operably coupled to an implantable pulse generator.