A tissue clipping device, comprising: a distal portion sized and shaped for insertion into a body lumen, the distal portion including a clip having a first clip arm, a proximal end of the clip movably housed within a lumen of.a capsule (106; 206; 306) extending longitudinally from a proximal end to a distal end such that the clip is movable relative to the capsule (106; 206; 306) between a tissue receiving configuration in which the first clip arm extends distally from a distal end of the capsule (106; 206; 306) in a biased open position and a tissue gripping configuration in which the first arm is retracted proximally within the capsule (106; 206; 306), the capsule (106; 206; 306) including a first window (128; 228; 328) extending laterally through a proximal end thereof; a bushing (102; 202; 302) extending from a proximal end to a distal end and including a channel extending therethrough, the distal end including a first bushing arm (104; 204; 304) extending distally therefrom such that the first bushing arm (104; 204; 304) is releasably engagable with the first window (128; 228; 328) of the capsule (106; 206; 306); and a core member (110; 210; 310) received within the capsule (106; 206; 306) and coupled to a proximal end of the clip arm, the core member (110; 210; 310) including a locking portion, the locking portion sized and shaped to be received within the channel of the bushing (102; 202; 302) to apply a radially outward pressure to the first bushing arm (104; 204; 304) such that the first bushing arm (104; 204; 304) engages the first window (128; 228; 328) of the capsule (106; 206; 306) characterised in that the core member includes a first engaging element (130; 230; 330), the first engaging element (130; 230; 330) extending radially outward from a portion of the core member (110; 210; 310) distal of the locking portion such that when the core member (110; 210; 310) is moved proximally relative to the capsule (106; 206; 306), the first engaging element (130; 230; 330) engages the first bushing arm (104; 204; 304) to deform the first bushing arm (104; 204; 304) radically inward and out of engagement with the first window (128; 228; 328) of the capsule (106; 206; 306). a distal portion sized and shaped for insertion into a body lumen, the distal portion including a clip having a first clip arm, a proximal end of the clip movably housed within a lumen of.a capsule (106; 206; 306) extending longitudinally from a proximal end to a distal end such that the clip is movable relative to the capsule (106; 206; 306) between a tissue receiving configuration in which the first clip arm extends distally from a distal end of the capsule (106; 206; 306) in a biased open position and a tissue gripping configuration in which the first arm is retracted proximally within the capsule (106; 206; 306), the capsule (106; 206; 306) including a first window (128; 228; 328) extending laterally through a proximal end thereof; a bushing (102; 202; 302) extending from a proximal end to a distal end and including a channel extending therethrough, the distal end including a first bushing arm (104; 204; 304) extending distally therefrom such that the first bushing arm (104; 204; 304) is releasably engagable with the first window (128; 228; 328) of the capsule (106; 206; 306); and a core member (110; 210; 310) received within the capsule (106; 206; 306) and coupled to a proximal end of the clip arm, the core member (110; 210; 310) including a locking portion, the locking portion sized and shaped to be received within the channel of the bushing (102; 202; 302) to apply a radially outward pressure to the first bushing arm (104; 204; 304) such that the first bushing arm (104; 204; 304) engages the first window (128; 228; 328) of the capsule (106; 206; 306) characterised in that the core member includes a first engaging element (130; 230; 330), the first engaging element (130; 230; 330) extending radially outward from a portion of the core member (110; 210; 310) distal of the locking portion such that when the core member (110; 210; 310) is moved proximally relative to the capsule (106; 206; 306), the first engaging element (130; 230; 330) engages the first bushing arm (104; 204; 304) to deform the first bushing arm (104; 204; 304) radically inward and out of engagement with the first window (128; 228; 328) of the capsule (106; 206; 306).