A pharmaceutical cartridge (700, 900, 1000, 1200, 1700, 1800) comprising: a unitary body portion including a cylindrical reservoir (542, 742, 902, 1842) having a longitudinal axis (758, 1393) and an extension (536, 736, 936, 1036, 1236, 1836) extending from a distal end of said reservoir (542, 742, 902, 1842); and a sterile tube (752, 938, 1238, 1438, 1538) having a sharpened tip (754, 948) projecting laterally beyond an edge of said reservoir (542, 742, 902, 1842), characterized in that: said tube (752, 938, 1238, 1438, 1538) is attached to a distal end of said reservoir (542, 742, 902, 1842) and an attachment point between said tube (752, 938, 1238, 1438, 1538) and said distal end of said reservoir (542, 742, 902, 1842) is offset from a longitudinal axis (758, 1393) of said reservoir (542, 742, 902, 1842); the extension (536, 736, 936, 1036, 1236, 1836) includes a bend (942, 1342); the sterile tube (752, 938, 1238, 1438, 1538) includes a portion (753, 1044) embedded in said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion and a straight part (751, 1038) extending from said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion; and a fluid path (750, 934, 1034, 1850) connecting the reservoir (542, 742, 902, 1842) to the sharpened tip (754, 948) is entirely contained within components of the set consisting of the unitary body and the tube (752, 938, 1238, 1438, 1538). a unitary body portion including a cylindrical reservoir (542, 742, 902, 1842) having a longitudinal axis (758, 1393) and an extension (536, 736, 936, 1036, 1236, 1836) extending from a distal end of said reservoir (542, 742, 902, 1842); and a sterile tube (752, 938, 1238, 1438, 1538) having a sharpened tip (754, 948) projecting laterally beyond an edge of said reservoir (542, 742, 902, 1842), characterized in that: said tube (752, 938, 1238, 1438, 1538) is attached to a distal end of said reservoir (542, 742, 902, 1842) and an attachment point between said tube (752, 938, 1238, 1438, 1538) and said distal end of said reservoir (542, 742, 902, 1842) is offset from a longitudinal axis (758, 1393) of said reservoir (542, 742, 902, 1842); the extension (536, 736, 936, 1036, 1236, 1836) includes a bend (942, 1342); the sterile tube (752, 938, 1238, 1438, 1538) includes a portion (753, 1044) embedded in said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion and a straight part (751, 1038) extending from said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion; and a fluid path (750, 934, 1034, 1850) connecting the reservoir (542, 742, 902, 1842) to the sharpened tip (754, 948) is entirely contained within components of the set consisting of the unitary body and the tube (752, 938, 1238, 1438, 1538). said tube (752, 938, 1238, 1438, 1538) is attached to a distal end of said reservoir (542, 742, 902, 1842) and an attachment point between said tube (752, 938, 1238, 1438, 1538) and said distal end of said reservoir (542, 742, 902, 1842) is offset from a longitudinal axis (758, 1393) of said reservoir (542, 742, 902, 1842); the extension (536, 736, 936, 1036, 1236, 1836) includes a bend (942, 1342); the sterile tube (752, 938, 1238, 1438, 1538) includes a portion (753, 1044) embedded in said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion and a straight part (751, 1038) extending from said extension (536, 736, 936, 1036, 1236, 1836) of said unitary body portion; and a fluid path (750, 934, 1034, 1850) connecting the reservoir (542, 742, 902, 1842) to the sharpened tip (754, 948) is entirely contained within components of the set consisting of the unitary body and the tube (752, 938, 1238, 1438, 1538).