mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula: or a salt thereof, wherein R 1 is a group of formula (i), (ii), (iii) (iv) or (v): R 2 is a C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), methanesulphonyl, a halogeno-C 1-6 alkyl or a halogen, R 3 is i) a phenyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl, a halogeno-C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), an -O-(halogeno-C 1-6 alkyl), cyano, nitro, methanesulphonyl and a halogen, ii) a C 3-8 cycloalkyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl and a halogen, iii) a pyridyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl, a halogeno-C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), an -O-(halogeno-C 1-6 alkyl), cyano, nitro, methanesulphonyl and a halogen, iv) a pyrazolyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl and a halogen, or v) a pyrrolidinyl optionally substituted with a C 1-6 alkyl, R 4 is H or F, L is a bond, CO, SO 2, O or NH, X is CH 2, O or N-methyl, Y is CH 2 or O, R a is H or methyl, R b is H, methyl, ethyl or -(CH 2) 2 O-CH 3, R c is H, methyl or oxetanyl, R d is H, methyl, -(CH 2) 2 OH, -(CH 2) 2 O-CH 3 or oxetanyl, m is 1 or 2, and n is 1 or 2. R 1 is a group of formula (i), (ii), (iii) (iv) or (v): R 2 is a C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), methanesulphonyl, a halogeno-C 1-6 alkyl or a halogen, R 3 is i) a phenyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl, a halogeno-C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), an -O-(halogeno-C 1-6 alkyl), cyano, nitro, methanesulphonyl and a halogen, ii) a C 3-8 cycloalkyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl and a halogen, iii) a pyridyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl, a halogeno-C 1-6 alkyl, a C 3-5 cycloalkyl, an -O-(C 1-6 alkyl), an -O-(halogeno-C 1-6 alkyl), cyano, nitro, methanesulphonyl and a halogen, iv) a pyrazolyl optionally substituted with a group selected from the group consisting of a C 1-6 alkyl and a halogen, or v) a pyrrolidinyl optionally substituted with a C 1-6 alkyl, R 4 is H or F, L is a bond, CO, SO 2, O or NH, X is CH 2, O or N-methyl, Y is CH 2 or O, R a is H or methyl, R b is H, methyl, ethyl or -(CH 2) 2 O-CH 3, R c is H, methyl or oxetanyl, R d is H, methyl, -(CH 2) 2 OH, -(CH 2) 2 O-CH 3 or oxetanyl, m is 1 or 2, and n is 1 or 2.
Equipment for selectively depositing by shockwave-induced spraying at least one particle onto a deposition surface of a receiver substrate, said equipment comprising: - at least one laser source configured to emit a laser beam, said laser beam being made up of a series of light pulses; - a substrate carrier to which the substrate is fastened; - a shockwave-generating layer comprising a first surface that is oriented toward the laser beam and a second surface that is oriented toward the deposition surface of the substrate; - an optical system for directing and focusing said laser beam toward a focal region of the first surface of the generating layer; - said second surface comprising a plurality of cavities, each of the cavities housing at least one particle; - said laser beam being configured to generate a plasma in the focal region on the first surface of the generating layer and a shockwave that propagates within the generating layer from the first surface to the second surface of the generating layer in order to eject at least one particle in the direction of the deposition surface of the receiver substrate. - at least one laser source configured to emit a laser beam, said laser beam being made up of a series of light pulses; - a substrate carrier to which the substrate is fastened; - a shockwave-generating layer comprising a first surface that is oriented toward the laser beam and a second surface that is oriented toward the deposition surface of the substrate; - an optical system for directing and focusing said laser beam toward a focal region of the first surface of the generating layer; - said second surface comprising a plurality of cavities, each of the cavities housing at least one particle; - said laser beam being configured to generate a plasma in the focal region on the first surface of the generating layer and a shockwave that propagates within the generating layer from the first surface to the second surface of the generating layer in order to eject at least one particle in the direction of the deposition surface of the receiver substrate.
A method of handling packet error for a communication device in a wireless communication system, the method comprising: obtaining a payload corresponding to the communication device from a received protocol data unit, hereinafter called PDU; characterized by that the method further comprising: verifying the payload according to a predetermined payload format, wherein verifying the payload according to the predetermined payload format comprises verifying a length and value range of payload elements and verifying a temporary cell radio network temporary identifier. obtaining a payload corresponding to the communication device from a received protocol data unit, hereinafter called PDU; characterized by that the method further comprising: verifying the payload according to a predetermined payload format, wherein verifying the payload according to the predetermined payload format comprises verifying a length and value range of payload elements and verifying a temporary cell radio network temporary identifier.
A blood flow measurement system, comprising: a catheter configured for placement within a gastrointestinal tract of a patient, the catheter comprising: a distal end, a proximal end, an expandable member disposed near the distal end, a lumen extending between the proximal end and the expandable member, and an optical sensor disposed adjacent to the expandable member, the optical sensor configured to generate a signal indicative of blood flow within the gastrointestinal tract; and a processor operatively coupled to the optical sensor and the expandable member, the processor configured to control the optical sensor and to receive the signal, characterised in that the processor is further configured to control periodic inflation and deflation of the expandable member. a catheter configured for placement within a gastrointestinal tract of a patient, the catheter comprising: a distal end, a proximal end, an expandable member disposed near the distal end, a lumen extending between the proximal end and the expandable member, and an optical sensor disposed adjacent to the expandable member, the optical sensor configured to generate a signal indicative of blood flow within the gastrointestinal tract; and a distal end, a proximal end, an expandable member disposed near the distal end, a lumen extending between the proximal end and the expandable member, and an optical sensor disposed adjacent to the expandable member, the optical sensor configured to generate a signal indicative of blood flow within the gastrointestinal tract; and a processor operatively coupled to the optical sensor and the expandable member, the processor configured to control the optical sensor and to receive the signal, characterised in that the processor is further configured to control periodic inflation and deflation of the expandable member.
A terminal comprising: a receiver, which, in operation, receives information indicating a set of parameters related to a physical uplink control channel, PUCCH, resource; and a transmitter, which, in operation, transmits a uplink control information using the PUCCH resource determined based on the information, wherein the set of parameters includes a slot, a starting symbol within the slot, and a number of symbols for a PUCCH transmission, a plurality of sets, each set including parameters related to the PUCCH resource, are configured to the terminal, and the information indicates one set of the plurality of sets, characterized in that frequency domain resources of the PUCCH resource are represented by a starting resource block which is represented as an offset from an edge of a bandwidth, a number of consecutive resource blocks, a number of clusters, and an inter-cluster distance, the set of parameters further includes the starting resource block, the number of clusters, and the inter-cluster distance, the number of consecutive resource blocks is associated with a format of the PUCCH when the number of consecutive resource blocks is not included in the set of parameters, and the terminal comprises a control unit which, in operation, determines the number of resource blocks by the format of the PUCCH. a receiver, which, in operation, receives information indicating a set of parameters related to a physical uplink control channel, PUCCH, resource; and a transmitter, which, in operation, transmits a uplink control information using the PUCCH resource determined based on the information, wherein the set of parameters includes a slot, a starting symbol within the slot, and a number of symbols for a PUCCH transmission, a plurality of sets, each set including parameters related to the PUCCH resource, are configured to the terminal, and the information indicates one set of the plurality of sets, characterized in that frequency domain resources of the PUCCH resource are represented by a starting resource block which is represented as an offset from an edge of a bandwidth, a number of consecutive resource blocks, a number of clusters, and an inter-cluster distance, the set of parameters further includes the starting resource block, the number of clusters, and the inter-cluster distance, the number of consecutive resource blocks is associated with a format of the PUCCH when the number of consecutive resource blocks is not included in the set of parameters, and the terminal comprises a control unit which, in operation, determines the number of resource blocks by the format of the PUCCH.
A method for choosing the sequence of bursts of an access pattern in the primary network of a cognitive wireless network comprising a primary and a secondary network, wherein this access pattern comprises an alternation of listen periods and signaling transmission periods, these periods having various lengths; comprising the steps of computing a random integer X, and then generating a sequence of bursts corresponding to the computed random integer X; characterized in that it comprises the steps of: - choosing a number p between 0 and 1 as a function of the wanted collision rate and choosing an integer L chosen of order loglog of the maximum size N of the primary network, these parameters p and L being common to all devices in the primary network; - computing the random integer X having a geometric distribution with a probability p; - when X<k L, letting m 1, m 2,..., m i,..., m L be the sequence that is encoded by X in a given base k; m i being integers chosen between 0 and k-1; - then deriving a preamble sequence from this integer sequence by taking BS(k-1-m 1), BS(k-1-m 2),..., BS(k-1-m L) as a preamble sequence, where BS(u) is the binary k-sequence which encodes the number u, u being an integer between 0 and k-1. - choosing a number p between 0 and 1 as a function of the wanted collision rate and choosing an integer L chosen of order loglog of the maximum size N of the primary network, these parameters p and L being common to all devices in the primary network; - computing the random integer X having a geometric distribution with a probability p; - when X<k L, letting m 1, m 2,..., m i,..., m L be the sequence that is encoded by X in a given base k; m i being integers chosen between 0 and k-1; - then deriving a preamble sequence from this integer sequence by taking BS(k-1-m 1), BS(k-1-m 2),..., BS(k-1-m L) as a preamble sequence, where BS(u) is the binary k-sequence which encodes the number u, u being an integer between 0 and k-1.
A method for identifying an aptamer having a slow rate of dissociation (t 1/2) from its target molecule, wherein the aptamer comprises at least one base-modified pyrimidine, the method comprising: (a) contacting a candidate mixture with a target molecule, wherein nucleic acids having an increased affinity to the target molecule relative to other nucleic acids in the candidate mixture bind the target molecule, forming nucleic acid-target molecule complexes and wherein the candidate mixture comprises modified nucleic acids in which one, several or all pyrimidines in at least one, or each, nucleic acid of the candidate mixture is chemically modified at the 5- position to form a base-modified pyrimidine; (b) partitioning the nucleic acid-target molecule complexes from the candidate mixture; (c) dissociating the nucleic acid-target molecule complexes to generate free nucleic acids; (d) amplifying the free nucleic acids to yield a mixture of nucleic acids enriched in sequences that are capable of binding to the target molecule with increased affinity, whereby an aptamer to the target molecule may be identified; (e) optionally, repeating (a) through (d) as necessary; (f) identifying at least one aptamer to the target molecule, wherein the aptamer comprises at least one base-modified pyrimidine, and (g) screening the aptamer(s) identified in (f) to identify aptamer(s) having a slow rate of dissociation (t 1/2) from the target molecule. (a) contacting a candidate mixture with a target molecule, wherein nucleic acids having an increased affinity to the target molecule relative to other nucleic acids in the candidate mixture bind the target molecule, forming nucleic acid-target molecule complexes and wherein the candidate mixture comprises modified nucleic acids in which one, several or all pyrimidines in at least one, or each, nucleic acid of the candidate mixture is chemically modified at the 5- position to form a base-modified pyrimidine; (b) partitioning the nucleic acid-target molecule complexes from the candidate mixture; (c) dissociating the nucleic acid-target molecule complexes to generate free nucleic acids; (d) amplifying the free nucleic acids to yield a mixture of nucleic acids enriched in sequences that are capable of binding to the target molecule with increased affinity, whereby an aptamer to the target molecule may be identified; (e) optionally, repeating (a) through (d) as necessary; (f) identifying at least one aptamer to the target molecule, wherein the aptamer comprises at least one base-modified pyrimidine, and (g) screening the aptamer(s) identified in (f) to identify aptamer(s) having a slow rate of dissociation (t 1/2) from the target molecule.
An aero-engine, comprising a fan rotor, a stator part intermediate case, a first bearing and a second bearing supporting the fan rotor, a first support cone wall supporting the first bearing on the stator part intermediate case, and a second support wall supporting the second bearing on the stator part intermediate case, the first support cone wall being of a thin-wall annular structure and comprising an upper cone wall having an upper junction surface and a lower cone wall having a lower junction surface, characterized in that the upper junction surface or the lower junction surface is a concave spherical surface while the other one is a convex spherical surface; the upper junction surface and the lower junction surface are complementary and welded into a fusing structure with strength being lower than that of a parent material, a center of a spherical surface of the fusing structure being located at an axis of the fan rotor.
A radio communication apparatus used as one of a plurality of second radio communication apparatus, which can be realized as subscriber stations in a radio communication system, the radio communication system including a first radio communication apparatus, which can be realized as a base station or relay station, configured to receive data from the plurality of second radio communication apparatus, the radio communication apparatus comprising: a detection section configured to detect at least one of a first radio resource that is assigned by the first radio communication apparatus and that can be used on a contention basis by the plurality of second radio communication apparatus for data transmission and a second radio resource for a control channel assigned by the first radio communication apparatus; and a transmission processing section configured to selectively perform, according to a result of the detection by the detection section, indicating that first and second radio resources are assigned, one of three or more transmission methods including a first transmission method using the first radio resource for data transmission, a second transmission method by which data transmission is performed by performing a process using the second radio resource, and a third transmission method in which random access is performed to the first radio communication apparatus and a third radio resource assigned by the first radio communication apparatus is used for data transmission, thereby not performing the three or more transmission methods in parallel. a detection section configured to detect at least one of a first radio resource that is assigned by the first radio communication apparatus and that can be used on a contention basis by the plurality of second radio communication apparatus for data transmission and a second radio resource for a control channel assigned by the first radio communication apparatus; and a transmission processing section configured to selectively perform, according to a result of the detection by the detection section, indicating that first and second radio resources are assigned, one of three or more transmission methods including a first transmission method using the first radio resource for data transmission, a second transmission method by which data transmission is performed by performing a process using the second radio resource, and a third transmission method in which random access is performed to the first radio communication apparatus and a third radio resource assigned by the first radio communication apparatus is used for data transmission, thereby not performing the three or more transmission methods in parallel.
A method performed by a wireless device when operating in a wireless network, for handling handover from a source cell to a target cell when the wireless device has obtained and stored a handover configuration for at least one target cell X (106A-C), the method comprising: - performing cell selection upon detecting a communication failure, - determining whether the selected cell is one of the at least one target cell X for which a handover configuration has been obtained and stored; - initiating handover to one of the at least one target cell X (106A-C) when that target cell was selected in said cell selection, by applying the stored handover configuration of the selected cell, and - initiating an RRC re-establishment procedure when none of the at least one target cell X was selected in said cell selection. - performing cell selection upon detecting a communication failure, - determining whether the selected cell is one of the at least one target cell X for which a handover configuration has been obtained and stored; - initiating handover to one of the at least one target cell X (106A-C) when that target cell was selected in said cell selection, by applying the stored handover configuration of the selected cell, and - initiating an RRC re-establishment procedure when none of the at least one target cell X was selected in said cell selection.
Use of at least one compound binding to the sigma receptor and having an IC 50 value of ≤50 nM for the production of a medicament for the treatment of mechanical allodynia, characterized in that said compound binding to the sigma receptor is acting on the sigma receptor as an antagonist, characterized in that said compound binding to the sigma receptor is binding to the sigma-1 receptor subtype.
A method of estimating a plant characteristic, comprising: a. building a predictive model using inverse modeling using: i. a first set of spectroscopic data from a first plant population, and ii. corresponding measured characteristic data sets from the first plant population; and, b. applying the model to a second set of spectroscopic data from a second plant, a second plant population, or both, so as to estimate the characteristic in the second plant. a. building a predictive model using inverse modeling using: i. a first set of spectroscopic data from a first plant population, and ii. corresponding measured characteristic data sets from the first plant population; and, i. a first set of spectroscopic data from a first plant population, and ii. corresponding measured characteristic data sets from the first plant population; and, b. applying the model to a second set of spectroscopic data from a second plant, a second plant population, or both, so as to estimate the characteristic in the second plant.
A method for loading a fluid into a microcapillary array flow cell comprising a fluid access region encompassing a chip comprising a plurality of microcapillary wells, the method comprising: pumping said fluid into a fluid inlet hole of the microcapillary array flow cell, the fluid inlet hole in communication with a fluid outlet hole and said plurality of microcapillary wells, wherein said plurality of microcapillary wells are open to a bottom planar surface, wherein said microcapillary wells are through holes, wherein said fluid is distributed in a lateral path along a top planar surface of the plurality of microcapillary wells between the fluid inlet hole and the fluid outlet hole, the lateral path perpendicular to said microcapillary wells, wherein the exit pressure of the fluid from an outlet hole of the microcapillary array flow cell is lower than the surface tension of water, lower than the capillary well pressure, or lower than the liquid surface tension in the microcapillary wells, and wherein said fluid is distributed into said plurality of microcapillary wells. pumping said fluid into a fluid inlet hole of the microcapillary array flow cell, the fluid inlet hole in communication with a fluid outlet hole and said plurality of microcapillary wells, wherein said plurality of microcapillary wells are open to a bottom planar surface, wherein said microcapillary wells are through holes, wherein said fluid is distributed in a lateral path along a top planar surface of the plurality of microcapillary wells between the fluid inlet hole and the fluid outlet hole, the lateral path perpendicular to said microcapillary wells, wherein the exit pressure of the fluid from an outlet hole of the microcapillary array flow cell is lower than the surface tension of water, lower than the capillary well pressure, or lower than the liquid surface tension in the microcapillary wells, and wherein said fluid is distributed into said plurality of microcapillary wells.
A composition for preparing a bio-film resistant surface comprising (i) a biguanide present at between about 0.1 and 5 percent (weight/volume), (ii) an alkanediol present at between about 0.5 and 5 percent (volume/volume), (iii) a silver compound present at between about 0.05 and 3 percent (weight/volume), (iv) lactic acid in an amount between 0.5 and 3 percent (volume/volume), and (v) a solvent selected from the group consisting of methanol, ethanol, isopropanol, tetrahydrofuran, and mixtures thereof. (i) a biguanide present at between about 0.1 and 5 percent (weight/volume), (ii) an alkanediol present at between about 0.5 and 5 percent (volume/volume), (iii) a silver compound present at between about 0.05 and 3 percent (weight/volume), (iv) lactic acid in an amount between 0.5 and 3 percent (volume/volume), and (v) a solvent selected from the group consisting of methanol, ethanol, isopropanol, tetrahydrofuran, and mixtures thereof.