A multilayer surgical graft, comprising: a first remodelable extracellular matrix sheet; a second remodelable extracellular matrix sheet; and a synthetic mesh material with a plurality of mesh openings disposed between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet contacting one another through said plurality of mesh openings including through a first mesh opening to provide a first contacting region between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, wherein said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet are bonded to one another around the peripheral edges of the mesh material and through said plurality of mesh openings including through said first mesh opening to provide a first bonded region between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, wherein bonding of said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet to one another through said plurality of mesh openings and around the peripheral edges of said synthetic mesh material seals the synthetic mesh material within the first and second extracellular matrix sheets (41, 42), wherein said multilayer surgical graft includes a first passageway extending through said first remodelable extracellular matrix sheet, through said first mesh opening, and through said second remodelable extracellular matrix sheet within said first bonded region, wherein said first bonded region extends laterally beyond and fully around said first open passageway, and said first passageway allows passage of fluids through the passageway from a first side of the surgical graft to a second side of the surgical graft. a first remodelable extracellular matrix sheet; a second remodelable extracellular matrix sheet; and a synthetic mesh material with a plurality of mesh openings disposed between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet contacting one another through said plurality of mesh openings including through a first mesh opening to provide a first contacting region between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, wherein said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet are bonded to one another around the peripheral edges of the mesh material and through said plurality of mesh openings including through said first mesh opening to provide a first bonded region between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, wherein bonding of said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet to one another through said plurality of mesh openings and around the peripheral edges of said synthetic mesh material seals the synthetic mesh material within the first and second extracellular matrix sheets (41, 42), wherein said multilayer surgical graft includes a first passageway extending through said first remodelable extracellular matrix sheet, through said first mesh opening, and through said second remodelable extracellular matrix sheet within said first bonded region, wherein said first bonded region extends laterally beyond and fully around said first open passageway, and said first passageway allows passage of fluids through the passageway from a first side of the surgical graft to a second side of the surgical graft.