A method of preparing a sterile human placental allograft comprising: (a) providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; and either before step (a) or during step (a) disinfecting the human placental tissue with at least one of a bactericidal composition, a tuberculocidal composition, a fungicidal composition, a virucidal composition, or any combination thereof; wherein the at least one of a bactericidal composition, tuberculocidal composition, fungicidal composition, virucidal composition, or any combination thereof includes an isopropyl alcohol at a concentration of 70% to 100%; (b) removing any visible blood, blood clots, and/or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; (c) washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue, preferably repeating step (c) for a predetermined number of times, wherein each wash step (c) is at a temperature ranging from 4 to 15 °C for a time-period of from 5 minutes to 15 minutes (d) dehydrating the human placental tissue thereby forming the dehydrated human placental tissue, wherein the dehydrating step (d) is at a temperature ranging from 20 to 40 °C for a time-period of from 60 minutes to 4.5 hours; (e) resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and (f) sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft, wherein the sterilizing step (f) comprises sterilizing with e-beam irradiation. (a) providing a human placental tissue from a donor within 24 hours to 72 hours post-childbirth; and either before step (a) or during step (a) disinfecting the human placental tissue with at least one of a bactericidal composition, a tuberculocidal composition, a fungicidal composition, a virucidal composition, or any combination thereof; wherein the at least one of a bactericidal composition, tuberculocidal composition, fungicidal composition, virucidal composition, or any combination thereof includes an isopropyl alcohol at a concentration of 70% to 100%; and either before step (a) or during step (a) disinfecting the human placental tissue with at least one of a bactericidal composition, a tuberculocidal composition, a fungicidal composition, a virucidal composition, or any combination thereof; wherein the at least one of a bactericidal composition, tuberculocidal composition, fungicidal composition, virucidal composition, or any combination thereof includes an isopropyl alcohol at a concentration of 70% to 100%; (b) removing any visible blood, blood clots, and/or blood components from the human placental tissue without scraping or scrubbing the human placental tissue to preserve structural integrity of the human placental tissue; (c) washing the human placental tissue in an isotonic solution while maintaining the structural integrity of the human placental tissue, preferably repeating step (c) for a predetermined number of times, wherein each wash step (c) is at a temperature ranging from 4 to 15 °C for a time-period of from 5 minutes to 15 minutes (d) dehydrating the human placental tissue thereby forming the dehydrated human placental tissue, wherein the dehydrating step (d) is at a temperature ranging from 20 to 40 °C for a time-period of from 60 minutes to 4.5 hours; (e) resizing the dehydrated human placental tissue into dehydrated human placental tissue portions having predetermined sizes; and (f) sterilizing the dehydrated human placental tissue portions of step (e) thereby forming the sterile human placental allograft,