A method of making a transparent, thermoformed high barrier plastic bottle, which includes the following steps: providing a transparent barrier film including first and second outer layers (12, 14) formed using an amorphous polymer, an inner nanolayer sequence including a plurality of nanolayers (28, 30, 32) a) including ethylene vinyl alcohol, alternating with nanolayers (22, 24, 26) b) including at least one of ethylene ethyl acrylate, ethylene acrylic acid, low density polyethylene and linear low density polyethylene, each of the nanolayers b) having a degree of crystallinity less than about 45%, and adhesive layers (16, 18) between each of the two outer layers and the inner nanolayer sequence; heating the transparent barrier film; drawing the transparent barrier film over a neck end of a hollow perforated mold having a shape of a bottle; the hollow perforated mold having a perforated narrower neck end, a perforated wider main body, and an open or perforated bottom end; drawing a vacuum through perforations in the hollow perforated mold from an interior of the mold, causing the transparent barrier film to thermoform around an exterior of the hollow perforated mold and form a bottle with an open bottom end; discontinuing the vacuum and applying compressed gas to the interior of the mold from the open or perforated bottom end of the mold, causing the bottle with open bottom end to discharge from the mold; filling the bottle with a product through the open bottom end to form a filled bottle; and closing the bottom end of the filled bottle by sealing the bottom end with a flat sheet or a flat portion of the transparent barrier film. providing a transparent barrier film including first and second outer layers (12, 14) formed using an amorphous polymer, an inner nanolayer sequence including a plurality of nanolayers (28, 30, 32) a) including ethylene vinyl alcohol, alternating with nanolayers (22, 24, 26) b) including at least one of ethylene ethyl acrylate, ethylene acrylic acid, low density polyethylene and linear low density polyethylene, each of the nanolayers b) having a degree of crystallinity less than about 45%, and adhesive layers (16, 18) between each of the two outer layers and the inner nanolayer sequence; heating the transparent barrier film; drawing the transparent barrier film over a neck end of a hollow perforated mold having a shape of a bottle; the hollow perforated mold having a perforated narrower neck end, a perforated wider main body, and an open or perforated bottom end; drawing a vacuum through perforations in the hollow perforated mold from an interior of the mold, causing the transparent barrier film to thermoform around an exterior of the hollow perforated mold and form a bottle with an open bottom end; discontinuing the vacuum and applying compressed gas to the interior of the mold from the open or perforated bottom end of the mold, causing the bottle with open bottom end to discharge from the mold; filling the bottle with a product through the open bottom end to form a filled bottle; and closing the bottom end of the filled bottle by sealing the bottom end with a flat sheet or a flat portion of the transparent barrier film.