mhurhangee/ep-ind-claims huggingface dataset:
A method of expanding definitive endoderm cells in culture, said method comprising the steps of: (a) isolating a portion of the definitive endoderm cells from a portion of the other cells in a cell culture comprising definitive endoderm cells, thereby producing a cell population enriched in definitive endoderm cells; and (b) culturing said cell population enriched in definitive endoderm cells under conditions that permit the expansion of said definitive endoderm cells, wherein said culturing step comprises incubating said population enriched in definitive endoderm cells or a portion thereof in a medium comprising a growth factor from the TGFβ superfamily of growth factors selected from the group consisting of activin A, activin B and combinations of these factors. (a) isolating a portion of the definitive endoderm cells from a portion of the other cells in a cell culture comprising definitive endoderm cells, thereby producing a cell population enriched in definitive endoderm cells; and (b) culturing said cell population enriched in definitive endoderm cells under conditions that permit the expansion of said definitive endoderm cells, wherein said culturing step comprises incubating said population enriched in definitive endoderm cells or a portion thereof in a medium comprising a growth factor from the TGFβ superfamily of growth factors selected from the group consisting of activin A, activin B and combinations of these factors.
A multiphase emulsion polymer comprising at least one hard phase polymer having a glass transition temperature of from 0 to 100° C and at least one soft phase polymer having a glass transition temperature of less than 0° C and at least 20° C lower than the glass transition temperature of the hard phase polymer, wherein the hard phase polymer is a copolymer of at least one ethylenically unsaturated monomer and at least one oxyalkylene-containing (meth)acrylate corresponding to formula or or a mixture thereof: CH 2 =C(R 1)-C(=O)-O-[X-O] n -R 2; CH 2 =C(R 1)-C(=O)-O-[X-O] n -P(=O) 2; wherein R 1 is H or CH 3, R 2 is H or a Ci-Cs alkyl group, each X is independently -(CH 2) 2 -, -CH 2 CH(CH 3)- or -CH(CH 3)CH 2 -, each Y is independently H, ammonium or an alkali metal atom, and n is an integer of from 1 to 30 and wherein the said multiphase emulsion polymer is in the form of latex particles and wherein the latex particles comprise an inner phase comprised of the soft phase polymer and an outer phase comprised of the hard phase polymer and the said soft polymer phase represents from 90% to 40% by weight of the multiphase emulsion polymer and the said hard polymer phase represents from 10% to 60% by weight of the multiphase emulsion polymer, the total weight amount of soft polymer phase and hard polymer phase equaling 100%. wherein R 1 is H or CH 3, R 2 is H or a Ci-Cs alkyl group, each X is independently -(CH 2) 2 -, -CH 2 CH(CH 3)- or -CH(CH 3)CH 2 -, each Y is independently H, ammonium or an alkali metal atom, and n is an integer of from 1 to 30 and wherein the said multiphase emulsion polymer is in the form of latex particles and wherein the latex particles comprise an inner phase comprised of the soft phase polymer and an outer phase comprised of the hard phase polymer and the said soft polymer phase represents from 90% to 40% by weight of the multiphase emulsion polymer and the said hard polymer phase represents from 10% to 60% by weight of the multiphase emulsion polymer, the total weight amount of soft polymer phase and hard polymer phase equaling 100%.
A compound of formula or a stereoisomeric form thereof, wherein R 1 is selected from pyridinyl, morpholinyl and pyrrolidinyl; R 2 is selected from hydrogen, methyl, ethyl, cyclopropyl, isopropyl, methoxy and trifluoromethyl; R 3 is selected from hydrogen, chloro, methyl, trifluoromethyl and cyclopropyl; Het is selected from pyridinyl and pyrazolyl; R 4 is selected from hydrogen; methyl; ethyl; isopropyl; isobutyl; trifluoromethyl; 2,2,2-trifluoroethyl; 2-hydroxy-2-methylpropyl; (2,2-difluorocyclopropyl)methyl; 2,2-difluoro-2-cyclopropylethyl; cyclopropyl; 2-methoxyethyl; 2-methoxypropyl; (2 S)-2-methoxypropyl; 2-isopropoxyethyl; 2-ethoxyethyl; ethoxymethyl; 1-methoxy-1-methylethyl; 1-methoxy-1-methylethyl; 2-methoxy-1,1-dimethylethyl; 3-methoxy-3-methylbutyl; 3-methoxypropyl; 2-methoxy-2-methyl-propyl; isopropoxy; 2,2,2-trifluoroethoxy; cyclopropylmethoxy; 2-methoxyethoxy; 2-methoxy-2-methylpropoxy; tetrahydro- 2H -pyran-4-yl; (pyridin-3-yl)methyl; 2-(pyrrolidin-1-yl)ethyl; isopropylamino; morpholin-4-yl; pyrrolidin-1-yl; piperazin-1-yl; -3-methoxypyrrolidin-1-yl; and (3 S)-3-methoxypyrrolidin-1-yl; and R 5 is hydrogen or methyl or a pharmaceutically acceptable salt or a solvate thereof. R 1 is selected from pyridinyl, morpholinyl and pyrrolidinyl; R 2 is selected from hydrogen, methyl, ethyl, cyclopropyl, isopropyl, methoxy and trifluoromethyl; R 3 is selected from hydrogen, chloro, methyl, trifluoromethyl and cyclopropyl; Het is selected from pyridinyl and pyrazolyl; R 4 is selected from hydrogen; methyl; ethyl; isopropyl; isobutyl; trifluoromethyl; 2,2,2-trifluoroethyl; 2-hydroxy-2-methylpropyl; (2,2-difluorocyclopropyl)methyl; 2,2-difluoro-2-cyclopropylethyl; cyclopropyl; 2-methoxyethyl; 2-methoxypropyl; (2 S)-2-methoxypropyl; 2-isopropoxyethyl; 2-ethoxyethyl; ethoxymethyl; 1-methoxy-1-methylethyl; 1-methoxy-1-methylethyl; 2-methoxy-1,1-dimethylethyl; 3-methoxy-3-methylbutyl; 3-methoxypropyl; 2-methoxy-2-methyl-propyl; isopropoxy; 2,2,2-trifluoroethoxy; cyclopropylmethoxy; 2-methoxyethoxy; 2-methoxy-2-methylpropoxy; tetrahydro- 2H -pyran-4-yl; (pyridin-3-yl)methyl; 2-(pyrrolidin-1-yl)ethyl; isopropylamino; morpholin-4-yl; pyrrolidin-1-yl; piperazin-1-yl; -3-methoxypyrrolidin-1-yl; and (3 S)-3-methoxypyrrolidin-1-yl; and R 5 is hydrogen or methyl
Mammography-apparatus for detecting malignant cells in a breast comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against an x-ray detector cover, and comprising a contact area measuring device for measuring a contact area between the breast and the mammography-apparatus, wherein the contact area measuring device comprises a laminate of an electrically low resistance material (7") sandwiched between two layers of an electrically insulating material (7', 7′′′), with the contact area measuring device being embodied with a measurement circuit and equipped to be connected during use to an alternating current excitation source for measuring the electrical potential between the X-ray detector cover and the electrically low resistance material (7") of the laminate on the detector cover characterized in that the paddle is replaceable and embodied without a contact area measuring device and that the contact area measuring device is only provided on or incorporated in the detector cover facing the breast.
A refrigerant charging method of recovering a refrigerant and charging the refrigerant to a second heat source unit, the refrigerant being included in a first heat source unit of an already installed refrigeration cycle apparatus having a utilization unit and in which a refrigeration cycle is to be performed by the refrigerant that circulates, wherein the utilization unit is connected to the first heat source unit and the first heat source unit includes a high-pressure-side shutoff valve and a low-pressure-side shutoff valve, the method comprising: a step of closing the high-pressure-side shutoff valve and the low-pressure-side shutoff valve of the first heat source unit; a step of detaching the first heat source unit from the already installed refrigeration cycle apparatus; a step of incorporating the second heat source unit into the already installed refrigeration cycle apparatus; a step of transferring a first refrigerant from the first heat source unit to the second heat source unit, thereby obtaining a recovered refrigerant, wherein the second heat source unit is configured to be connected to a power source and in an operable state, the first heat source unit and the second heat source unit are connected to each other by a charge hose, and the first refrigerant is transferred from the first heat source unit through the charge hose to the second heat source unit; and then a step of further charging a second refrigerant whose composition differs from a composition of the recovered refrigerant to the already installed refrigeration cycle apparatus that includes the second heat source unit. a step of closing the high-pressure-side shutoff valve and the low-pressure-side shutoff valve of the first heat source unit; a step of detaching the first heat source unit from the already installed refrigeration cycle apparatus; a step of incorporating the second heat source unit into the already installed refrigeration cycle apparatus; a step of transferring a first refrigerant from the first heat source unit to the second heat source unit, thereby obtaining a recovered refrigerant, wherein the second heat source unit is configured to be connected to a power source and in an operable state, the first heat source unit and the second heat source unit are connected to each other by a charge hose, and the first refrigerant is transferred from the first heat source unit through the charge hose to the second heat source unit; and then a step of further charging a second refrigerant whose composition differs from a composition of the recovered refrigerant to the already installed refrigeration cycle apparatus that includes the second heat source unit.
A medical device implantation apparatus, comprising: an outer sheath, connected to a first portion of a handle and extending from a proximal end to a distal end; a middle sheath, the middle sheath being arranged in the outer sheath, and the middle sheath being connected to a second portion of the handle; an inner sheath, the inner sheath being allowed to pass through the middle sheath, the inner sheath being connected to a third portion of the handle, and the inner sheath being movable relative to the outer sheath; outer casings, with at least two outer casings being provided; and a medical device, arranged around the inner sheath, wherein the inner sheath moves relative to the outer sheath by manipulating the third portion of the handle to release the medical device, wherein the medical device is partially accommodated in the outer casings, characterized in that the inner sheath has a distal end bifurcation structure, and portions of the distal end bifurcation structure are connected to the first outer casing and the second outer casing, respectively wherein during implantation a distal end of the middle sheath is abutted against a proximal end of the medical device to limit the position of the medical device. an outer sheath, connected to a first portion of a handle and extending from a proximal end to a distal end; a middle sheath, the middle sheath being arranged in the outer sheath, and the middle sheath being connected to a second portion of the handle; an inner sheath, the inner sheath being allowed to pass through the middle sheath, the inner sheath being connected to a third portion of the handle, and the inner sheath being movable relative to the outer sheath; outer casings, with at least two outer casings being provided; and a medical device, arranged around the inner sheath, wherein the inner sheath moves relative to the outer sheath by manipulating the third portion of the handle to release the medical device, wherein the medical device is partially accommodated in the outer casings, characterized in that the inner sheath has a distal end bifurcation structure, and portions of the distal end bifurcation structure are connected to the first outer casing and the second outer casing, respectively wherein during implantation a distal end of the middle sheath is abutted against a proximal end of the medical device to limit the position of the medical device.
A method of providing high availability for a network, the method comprising: configuring a first supervisor in a first chassis of a virtual network device as an active supervisor; configuring a second supervisor in a second chassis of the virtual network device as a standby supervisor for the virtual network device, the second supervisor being kept in a hot standby state; configuring a third supervisor in the first chassis as a first pseudo-standby supervisor, wherein the first pseudo-standby supervisor is kept in data-plane hot state and control plane warm state by the first supervisor; wherein a standby supervisor operating in a warm state has, for example, its configuration state continuously synchronized to match the running configuration of the active supervisor; and wherein a standby supervisor operating in a hot state has, for example, also its routing tables and port index tables, continuously synchronized to match those of the active supervisor. configuring a first supervisor in a first chassis of a virtual network device as an active supervisor; configuring a second supervisor in a second chassis of the virtual network device as a standby supervisor for the virtual network device, the second supervisor being kept in a hot standby state; configuring a third supervisor in the first chassis as a first pseudo-standby supervisor, wherein the first pseudo-standby supervisor is kept in data-plane hot state and control plane warm state by the first supervisor; wherein a standby supervisor operating in a warm state has, for example, its configuration state continuously synchronized to match the running configuration of the active supervisor; and wherein a standby supervisor operating in a hot state has, for example, also its routing tables and port index tables, continuously synchronized to match those of the active supervisor.
A method of receiving an optical signal modulated with a transmitted electrical signal which comprises an information-bearing component and a pilot tone having a predetermined frequency, the method comprising steps of: detecting the optical signal to produce a received electrical signal comprising a distorted variant of the transmitted electrical signal, wherein sources of distortion of the received signal include nonlinear optical transmission impairments; extracting the pilot tone from the received electrical signal; determining a compensation signal based upon the extracted pilot tone; and processing the received electrical signal using the compensation signal to produce a compensated signal having reduced distortion resulting from said nonlinear optical transmission impairments, wherein the processing comprises multiplying the received electrical signal by the compensation signal, the method characterized in that: the extracting step is performed using an adaptive filter having at least an adaptive bandwidth parameter; the compensation signal comprises a complex conjugate of the extracted pilot tone; and the adaptive bandwidth parameter is determined via feedback optimisation so as to substantially maximise a measure of quality of the compensated signal. detecting the optical signal to produce a received electrical signal comprising a distorted variant of the transmitted electrical signal, wherein sources of distortion of the received signal include nonlinear optical transmission impairments; extracting the pilot tone from the received electrical signal; determining a compensation signal based upon the extracted pilot tone; and processing the received electrical signal using the compensation signal to produce a compensated signal having reduced distortion resulting from said nonlinear optical transmission impairments, wherein the processing comprises multiplying the received electrical signal by the compensation signal, the method characterized in that: the extracting step is performed using an adaptive filter having at least an adaptive bandwidth parameter; the compensation signal comprises a complex conjugate of the extracted pilot tone; and the adaptive bandwidth parameter is determined via feedback optimisation so as to substantially maximise a measure of quality of the compensated signal. the extracting step is performed using an adaptive filter having at least an adaptive bandwidth parameter; the compensation signal comprises a complex conjugate of the extracted pilot tone; and the adaptive bandwidth parameter is determined via feedback optimisation so as to substantially maximise a measure of quality of the compensated signal.
A connector housing comprising a cover for closing an opening in the connector housing; the cover comprising: at least one through hole, adapted to receive a cable; and at least two flexible arms extending from the cover in closing direction adapted to retain a cable received in the through hole; and wherein the connector housing comprises a cavity, adapted to at least partially receive the flexible arms in a closed condition of the cover; and wherein each of the flexible arms, comprises an outer contact surface, characterized in that at least five flexible arms are provided; the outer contact surface comprises at least a first step; in closed condition, the first step engages a cavity wall, such that the flexible arms are biased towards any cable received in said through hole at a continuous inner contact surface extending from tips of the flexible arms over at least 30% of the length of the flexible arms, a second step is provided at the outer contact surface, the second step engages a front edge of the cavity wall in closed condition; and the second step blocks further movement of the flexible arms in closing direction. at least one through hole, adapted to receive a cable; and at least two flexible arms extending from the cover in closing direction adapted to retain a cable received in the through hole; and wherein the connector housing comprises a cavity, adapted to at least partially receive the flexible arms in a closed condition of the cover; and wherein each of the flexible arms, comprises an outer contact surface, characterized in that at least five flexible arms are provided; the outer contact surface comprises at least a first step; in closed condition, the first step engages a cavity wall, such that the flexible arms are biased towards any cable received in said through hole at a continuous inner contact surface extending from tips of the flexible arms over at least 30% of the length of the flexible arms, a second step is provided at the outer contact surface, the second step engages a front edge of the cavity wall in closed condition; and the second step blocks further movement of the flexible arms in closing direction.
A process of production of a compound of formula wherein R 1 is a C 1 -C 4 -alkyl moiety, preferably -CH 3 or -CH 2 CH 3, R 2 is by rearrangement of the compound of formula wherein R 1 and R 2 have the same meanings as in formula, characterized in that the process is carried out in the present of at least one transition metal based catalyst, wherein the transition metal is Cu and/or Ti. R 1 is a C 1 -C 4 -alkyl moiety, preferably -CH 3 or -CH 2 CH 3, R 2 is by rearrangement of the compound of formula wherein R 1 and R 2 have the same meanings as in formula, characterized in that the process is carried out in the present of at least one transition metal based catalyst, wherein the transition metal is Cu and/or Ti.
A vacuum coating installation for homogeneous PVD coating of three-dimensional substrates, comprising a coating chamber, two or more magnetron sputtering sources or arc evaporator sources arranged peripherally within the coating chamber, one or more substrate carriers for holding the substrates, vacuum pumps and voltage sources (15, 16, 17, 18, 19), characterized in that an individual, central anode is connected to a pulsed voltage source and the respective magnetron sputtering sources or arc evaporator sources are connected to pulsed voltage sources (18, 18,...) and the substrate carriers are positoned between the anode and magnetron sputtering sources or arc evaporator sources.
A switchover method for multimedia broadcast multicast service, MBMS, transmission modes, comprising: a network side counting up a number of user equipments, UEs, which are receiving one or more MBMSs by means of a point to point, PTP, mode, if the network side determines to perform a switchover from the PTP mode to a point to multipoint, PTM, mode according to the counting result, and the network side determines that the PTM mode can be established successfully according to a priority rank of a PTM mode bearer of the one or more MBMSs and/or MBMS resources, then the network side notifying a UE that the one or more MBMSs will be switched to be transmitted by means of the PTM mode from the PTP mode, and transmitting relevant information of the one or more MBMSs to the UE; wherein the relevant information comprises one kind or a combination of the following information: multimedia broadcast multicast service single frequency network, MBSFN, area information of the MBMS under the PTM mode, start time information of the MBMS under the PTM mode, and a temporary mobile group identify, TMGI, corresponding to the MBMS under the PTM mode. a network side counting up a number of user equipments, UEs, which are receiving one or more MBMSs by means of a point to point, PTP, mode, if the network side determines to perform a switchover from the PTP mode to a point to multipoint, PTM, mode according to the counting result, and the network side determines that the PTM mode can be established successfully according to a priority rank of a PTM mode bearer of the one or more MBMSs and/or MBMS resources, then the network side notifying a UE that the one or more MBMSs will be switched to be transmitted by means of the PTM mode from the PTP mode, and transmitting relevant information of the one or more MBMSs to the UE; wherein the relevant information comprises one kind or a combination of the following information: multimedia broadcast multicast service single frequency network, MBSFN, area information of the MBMS under the PTM mode, start time information of the MBMS under the PTM mode, and a temporary mobile group identify, TMGI, corresponding to the MBMS under the PTM mode.
A body structure for a utility vehicle, having a roof outer skin and a side outer skin, which in each case have front transverse flanges (23, 25), which form a common windshield flange for a windshield and are connected in an overlapping manner at a first three-layer connection point, in particular, a welding point and are supported on a cross-member flange of a cross-member profile, wherein at the first three-layer connection point the transverse flanges (23, 25) of the roof- and side outer skin (7, 11) converge with their longitudinal flanges (19, 21), which form a roof channel, and wherein the cross-member profile is constructed from a cross-member center part and at least one cross-member console part, which lie one above the other in an overlapping manner at a second three-layer connection point, in particular, a welding point and are connected with one of the front transverse flanges (23, 25) of the roof- and the side outer skin (7, 11), characterized in that both in a first vehicle variant as well as in a second vehicle variant the two three-layer connection points (A1, A2) are spaced apart from one another by a transverse offset (Δy 1, Δy 2).