A method for selection of image points in the representation of an object, in particular biological tissue, comprising the steps of: a) generating a first image of at least a sub-portion of the object by means of a first image generating device; b) generating a second image (8, 8') of at least the sub-portion of the object from step a) by means of a second image generating device; c) defining first coordinates of at least some image points of the second image in a first coordinate system; d) defining second coordinates of the image points of the second image by mapping the first coordinates into a second coordinate system, which is different from the first coordinate system and is assigned to the first device; and e) generating a combined image of the object from the first image and for selected image points from the second image using the determined second coordinates of the image points of the second image, wherein the selection of the image points to be combined is determined by the selection of a sub-portion of the object f) wherein • the first image generating device comprises a light source and the sub-portion of the object to be selected is marked by generating at least one light spot on the object with aid of the light source, or • the sub-portion of the object is marked with aid of a separate, navigated instrument by means of a plurality of support points, g) such that generating of the combined image occurs by replacing or superimposing image points of the first image within the selected sub-portion of the object through the selected image points of the second image. a) generating a first image of at least a sub-portion of the object by means of a first image generating device; b) generating a second image (8, 8') of at least the sub-portion of the object from step a) by means of a second image generating device; c) defining first coordinates of at least some image points of the second image in a first coordinate system; d) defining second coordinates of the image points of the second image by mapping the first coordinates into a second coordinate system, which is different from the first coordinate system and is assigned to the first device; and e) generating a combined image of the object from the first image and for selected image points from the second image using the determined second coordinates of the image points of the second image, wherein the selection of the image points to be combined is determined by the selection of a sub-portion of the object f) wherein • the first image generating device comprises a light source and the sub-portion of the object to be selected is marked by generating at least one light spot on the object with aid of the light source, or • the sub-portion of the object is marked with aid of a separate, navigated instrument by means of a plurality of support points, • the first image generating device comprises a light source and the sub-portion of the object to be selected is marked by generating at least one light spot on the object with aid of the light source, or • the sub-portion of the object is marked with aid of a separate, navigated instrument by means of a plurality of support points, g) such that generating of the combined image occurs by replacing or superimposing image points of the first image within the selected sub-portion of the object through the selected image points of the second image.