A method of synchronizing one or more unsynchronized sequencing products, said method comprising: (a) hybridizing a plurality of sequencing primers to a plurality of target nucleic acids; (b) performing 50 or more successive rounds of sequencing, thereby producing a plurality of sequencing products, said plurality of sequencing products comprising said one or more unsynchronized sequencing products; wherein each round of said 50 or more successive rounds of sequencing comprising: extending said plurality of sequencing primers in the presence of one labeled nucleotide, and (c) after said 50 or more successive rounds of sequencing, performing one or more synchronization steps on said plurality of sequencing products comprising said one or more unsynchronized sequencing products, wherein each of said one or more synchronization steps comprises: (i) contacting said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a first set of three different unlabeled nucleotides selected from the group consisting of: dATP, dTTP, dCTP, dGTP and dUTP; (ii) extending said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a DNA polymerase; and (iii) optionally, removing said first set of three different unlabeled nucleotides, thereby synchronizing said one or more unsynchronized sequencing products. (a) hybridizing a plurality of sequencing primers to a plurality of target nucleic acids; (b) performing 50 or more successive rounds of sequencing, thereby producing a plurality of sequencing products, said plurality of sequencing products comprising said one or more unsynchronized sequencing products; wherein each round of said 50 or more successive rounds of sequencing comprising: extending said plurality of sequencing primers in the presence of one labeled nucleotide, and (c) after said 50 or more successive rounds of sequencing, performing one or more synchronization steps on said plurality of sequencing products comprising said one or more unsynchronized sequencing products, wherein each of said one or more synchronization steps comprises: (i) contacting said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a first set of three different unlabeled nucleotides selected from the group consisting of: dATP, dTTP, dCTP, dGTP and dUTP; (ii) extending said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a DNA polymerase; and (iii) optionally, removing said first set of three different unlabeled nucleotides, thereby synchronizing said one or more unsynchronized sequencing products. (i) contacting said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a first set of three different unlabeled nucleotides selected from the group consisting of: dATP, dTTP, dCTP, dGTP and dUTP; (ii) extending said plurality of sequencing products comprising said one or more unsynchronized sequencing products with a DNA polymerase; and (iii) optionally, removing said first set of three different unlabeled nucleotides, thereby synchronizing said one or more unsynchronized sequencing products.