mhurhangee/ep-ind-claims huggingface dataset:
3α-Hydroxysteroid dehydrogenase (3α-HSDH) which catalyses at least the stereospecific enzymatic reduction of a 3-ketosteroid to the corresponding 3-hydroxysteroid, in particular with stoichiometric consumption of NADH, wherein the enzyme possesses at least 80% sequence identity in relation to SEQ ID NO:4; and is selected among: a) the single mutants R34X 1 and L68X 2 and b) the double mutants R34X 1 /L68X 2 where X 1 represents N, C, S or L and X 2 represents A, C, K, S or V; c) addition mutants which are C-terminally extended by a tail comprising 9 consecutive histidine residues; and d) mutants as per a) and b), in each case additionally C-terminally extended by a tail comprising 1 to 10 histidine residues and/or N-terminally extended by a tail comprising 1 to 10 histidine residues; wherein this 3α-HSDH shows the following property profile in comparison with the 3α-HSDH with SEQ ID NO:4: i) an increased specific activity (v max [U/mg]) for dehydrocholic acid (DHCA) in the enzymatic reduction of DHCA with NADH as cofactor, ii) a reduced substrate inhibition by DHCA, iii) an increased specific activity (v max [U/mg]) for NADH in the enzymatic reduction of DHCA with NADH as cofactor, iv) it being possible for these properties i) to iii) to be present individually or in any combination. a) the single mutants R34X 1 and L68X 2 and R34X 1 and L68X 2 and b) the double mutants R34X 1 /L68X 2 where X 1 represents N, C, S or L and X 2 represents A, C, K, S or V; X 1 represents N, C, S or L and X 2 represents A, C, K, S or V; c) addition mutants which are C-terminally extended by a tail comprising 9 consecutive histidine residues; and d) mutants as per a) and b), in each case additionally C-terminally extended by a tail comprising 1 to 10 histidine residues and/or N-terminally extended by a tail comprising 1 to 10 histidine residues; i) an increased specific activity (v max [U/mg]) for dehydrocholic acid (DHCA) in the enzymatic reduction of DHCA with NADH as cofactor, ii) a reduced substrate inhibition by DHCA, iii) an increased specific activity (v max [U/mg]) for NADH in the enzymatic reduction of DHCA with NADH as cofactor, iv) it being possible for these properties i) to iii) to be present individually or in any combination.
A turbine component, comprising: a metallic wall (24, 26, 228) consisting of a material with a positive CTE and having opposed interior and exterior surfaces, the wall configured for directing a combustion gas stream in a gas turbine engine; and a hollow metallic negative CTE structure (48, 50, 54) rigidly attached to one of the surfaces, wherein the dimensions of said structure (48, 50, 54) decrease with increasing temperatures, wherein the negative CTE structure is monolithically formed with the metallic wall (24, 26, 228), characterized in that the negative CTE structure comprises a repeating two-dimensional array of generally hourglass-shaped cells, each cell having two spaced-apart concave walls joined by two spaced-apart convex walls. a metallic wall (24, 26, 228) consisting of a material with a positive CTE and having opposed interior and exterior surfaces, the wall configured for directing a combustion gas stream in a gas turbine engine; and a hollow metallic negative CTE structure (48, 50, 54) rigidly attached to one of the surfaces, wherein the dimensions of said structure (48, 50, 54) decrease with increasing temperatures, wherein the negative CTE structure is monolithically formed with the metallic wall (24, 26, 228), characterized in that the negative CTE structure comprises a repeating two-dimensional array of generally hourglass-shaped cells, each cell having two spaced-apart concave walls joined by two spaced-apart convex walls.
A vacuum glass sealing device comprising an air extraction table, an upper pressing plate and a heating device, wherein the air extraction table is provided with an accommodating groove for placing glass plates to be sealed, the upper pressing plate is pressable on the glass plates to be sealed in the accommodating groove and air-tightly connected with the air extraction table around the periphery of the accommodating groove, and then the glass plates to be sealed are sealable in a closed space; and the air extraction table and/or the upper pressing plate are provided with air extraction ports, for vacuumizing the closed space and the glass plates to be sealed in the closed space, characterized in that the heating device is suitable for heating the parts to be sealed on the glass plates to be sealed from the exterior of one side of the upper pressing plate and/or the exterior of one side of the air extraction table so as to complete metal welding of the parts to be sealed.
A diamond sintered body comprising diamond particles, a binder, and a void, said diamond particles having an average particle diameter of 2 μm or less; said diamond particles having a content of not less than 80 % by volume but less than 98 % by volume, said binder including a solid solution as well as an iron group element, wherein said solid solution contains carbon and tungsten and at least one element selected from a group consisting of titanium, zirconium, vanadium, niobium and chromium, said solid solution having a content of not less than 0.1 % by volume but less than 15 % by volume, and the iron group element having a content of not less than 0.1 % by volume but less than 3 % by volume; neighboring ones of said diamond particles being bonded to one another.
A cover anchor clip comprising: a plate shaped base section for retention in a foam body (112, 122); an anchor portion including a pair of extension portions that stands up from the base section and that are disposed facing each other, a pair of anchor claws that are formed at respective leading ends of the pair of extension portions, and that project out toward sides in which the extension portions mutually face each other so that the pair of anchor claws are configured to anchor an anchored member attached to a cover (114, 124) for covering the foam body (112, 122) when the anchored member is inserted between the pair of anchor claws, and a protrusion that is formed at each leading end of the pair of extension portions and that projects out to the opposite side to the mutually facing sides of the pair of extension portions; characterized by upstanding portions each of that stands up from the base section and each of that can make contact with either one of the protrusions in the event that either one of the extension portions undergoes elastic deformation such that the pair of anchor claws move away from each other. a plate shaped base section for retention in a foam body (112, 122); an anchor portion including a pair of extension portions that stands up from the base section and that are disposed facing each other, a pair of anchor claws that are formed at respective leading ends of the pair of extension portions, and that project out toward sides in which the extension portions mutually face each other so that the pair of anchor claws are configured to anchor an anchored member attached to a cover (114, 124) for covering the foam body (112, 122) when the anchored member is inserted between the pair of anchor claws, and a protrusion that is formed at each leading end of the pair of extension portions and that projects out to the opposite side to the mutually facing sides of the pair of extension portions; a pair of extension portions that stands up from the base section and that are disposed facing each other, a pair of anchor claws that are formed at respective leading ends of the pair of extension portions, and that project out toward sides in which the extension portions mutually face each other so that the pair of anchor claws are configured to anchor an anchored member attached to a cover (114, 124) for covering the foam body (112, 122) when the anchored member is inserted between the pair of anchor claws, and a protrusion that is formed at each leading end of the pair of extension portions and that projects out to the opposite side to the mutually facing sides of the pair of extension portions; characterized by upstanding portions each of that stands up from the base section and each of that can make contact with either one of the protrusions in the event that either one of the extension portions undergoes elastic deformation such that the pair of anchor claws move away from each other.
Method for operating a vehicle, in which as a function of a geographical position of the vehicle a control centre transmits at least one piece of information to a receiving device of the vehicle, wherein the control centre discloses the at least one piece of information associated with a predefined region (16, 18, 20, 22) in the form of a fixed tile and the at least one piece of information associated with the predefined region (16, 18, 20, 22), wherein the control centre makes the pieces of information available for retrieval by the use of publish/subscribe middleware, wherein the vehicle receives the at least one piece of information when a control device of the vehicle has subscribed to receiving pieces of information from the predefined region (16, 18, 20, 22) subscribed to by the control device of the vehicle, wherein the control device of the vehicle subscribes to receiving pieces of information, which are assigned to those predefined regions (16, 18, 20) through which a route determined by means of a navigation system of the vehicle runs, wherein the receiving device of the vehicle receives the at least one piece of information, as soon as the geographical position of the vehicle comes to lie in the predefined region, and wherein the receiving device of the vehicle receives pieces of information which are assigned to at least one other predefined region (18, 20, 22) than the one in which the geographical position of the vehicle comes to lie, when receiving the pieces of information at the geographical position of the vehicle is made easier than receiving it in the at least one other predefined region (18, 20, 22), because at the geographical position of the vehicle there are more powerful radio connections for receiving the pieces of information by means of the receiving device of the vehicle than in the at least one other predefined region (18, 20, 22).
A polymer builder comprising monomer units derived from itaconic acid and from 0.01 to 4.95 mole % polymerisation initiator based on the total amount of monomers, wherein said polymer contains less than 0.5 mole % of citraconic acid and/or mesaconic acid based on the number of monomer units in the polymer, and wherein from about 0.1 to about 60 % of the total acid groups from all monomers in the polymer are either esterified, contain an ether linkage, or a combination thereof.
A method for changing a random ID associated with a smartcard in a system having a card reader system interacting with the smartcard comprising: - providing an initial random ID code for the smartcard and storing the initial random ID code in a non-secure memory of the smartcard; and - providing a user of the smartcard with the option of generating, by means of a random number generator in the smartcard, a new random ID code for the smartcard via a user interface on the smartcard after an RF reset and storing the new random ID code in the non-secure memory, wherein the new random ID code is used together with an encryption key to encrypt private data. - providing an initial random ID code for the smartcard and storing the initial random ID code in a non-secure memory of the smartcard; and - providing a user of the smartcard with the option of generating, by means of a random number generator in the smartcard, a new random ID code for the smartcard via a user interface on the smartcard after an RF reset and storing the new random ID code in the non-secure memory, wherein the new random ID code is used together with an encryption key to encrypt private data.
A control device for an automatic reset apparatus, that comprises a plurality of electromechanical units, each of said units being electrically connected to a phase of an electrical system, said units being kinematically connected to one actuation mechanism (9, 10, 11, 12) of one common microswitch that is adapted to drive an electronic control device of a reset apparatus associated with a protection device of the system; each of said units operating independently of the other units and being adapted to use an electromagnetic field that is generated by the fault current in the phase connected thereto in order to act on said actuation mechanism (9,10,11,12) that acts on said microswitch, which is functionally connected to said electronic control device of said reset apparatus; a means for the independent fine adjustment of the fault current threshold of each unit that causes the actuation of said protection device discriminating any overload current values from short-circuit current values.
A fusion protein, comprising two protein domains separated by a heterologous protease cleavage site, wherein a first of said protein domains is a degradation domain, and a second of said protein domains is a chimeric antigen receptor, wherein the degradation domain has a first state associated with a first level of surface expression of the fusion protein and a second state associated with a second level of surface expression of the fusion protein, wherein the second level is increased, e.g., by at least 2, 3, 4, 5, 10, 20 or 30 fold over the first level in the presence of a stabilization compound, further wherein the degradation domain is chosen from an estrogen receptor domain, an FKB protein (FKBP) domain or a dihydrofolate reductase (DHFR) domain.
A silica composition, comprising: compound represented by the following general formula; and acryl- or methacryl-modified silica particles: where X - represents a halogen ion or a methyl sulfate ion, R 1 to R 4 each independently represent a hydrocarbon group having 1 to 36 carbon atoms, a hydrocarbon group having 1 to 36 carbon atoms that has any one or more kinds of substituents selected from an ester group, an amide group, and a hydroxyl group, or a polyether group represented by the following general formula, provided that at least one of R 1 to R 4 needs to represent a polyether group represented by the following general formula: where m represents a number of from 1 to 100 and R 5 represents an alkylene group having 2 to 4 carbon atoms, and wherein compound is contained in an amount of from 2 to 10 parts by mass with respect to 10 parts by mass of raw silica particles. compound represented by the following general formula; and acryl- or methacryl-modified silica particles: where X - represents a halogen ion or a methyl sulfate ion, R 1 to R 4 each independently represent a hydrocarbon group having 1 to 36 carbon atoms, a hydrocarbon group having 1 to 36 carbon atoms that has any one or more kinds of substituents selected from an ester group, an amide group, and a hydroxyl group, or a polyether group represented by the following general formula, provided that at least one of R 1 to R 4 needs to represent a polyether group represented by the following general formula: where m represents a number of from 1 to 100 and R 5 represents an alkylene group having 2 to 4 carbon atoms, and wherein compound is contained in an amount of from 2 to 10 parts by mass with respect to 10 parts by mass of raw silica particles.
Signal processing method for acquisition of a measured value, wherein a measurement signal (ADC, ADC') is filtered by a first digital filter and a second digital filter in a first period (S1, S1') up to reaching a first standstill criterion (SK1, SK1'), wherein the limit frequency of the first digital filter is higher than the limit frequency of the second filter and/or the order of the first digital filter is lower than the order of the second digital filter, wherein after reaching the first standstill criterion (SK1, SK1') a filter change to a adaptive third filter is initiated and after reaching a second standstill criterion (SK2, SK2') a final measured value is output, wherein the output signals of the first digital filter and of the second digital filter are calculated simultaneously and the adaptive third filter is formed in that the output values of the second digital filter are overwritten with the values of the first digital filter, and thereby, the adaptive third filter acts as strong filter from that point of time during a second time span or the adaptive third filter is formed in that the first digital filter is further calculated with the filter coefficients of the second digital filter from the beginning of the second time span.
A device for discharge of an electrostatic charge from a work piece, for example, in a painting plant, comprising an absorber for the removal and discharge of the electrostatic charges from the work piece, wherein a connecting device is provided between the work piece and absorber for the transfer of the electrostatic loads, wherein the absorber comprises an air-ionization device, characterized in that the air-ionization device is arranged in at least one air duct with a supply air and exhaust air opening and that at least one ventilation device is arranged in the air duct for the generation of an air flow.
A method for triggering a terminal to establish a connection or transmit data to a triggering server in a communication network including a network node, the method being for executing at the network node and comprising the steps of: evaluating whether or not the connection can be established from the terminal to the server, including determining whether the network is congested and/or whether a back-off timer is running and/or the remaining time of the back-off timer at the terminal; and transmitting a delivery delay indication to a device triggering control server for informing the triggering server, the delivery delay indication indicating at least one of impossibility of establishing the connection to the server after the trigger or a data transmission delay. evaluating whether or not the connection can be established from the terminal to the server, including determining whether the network is congested and/or whether a back-off timer is running and/or the remaining time of the back-off timer at the terminal; and transmitting a delivery delay indication to a device triggering control server for informing the triggering server, the delivery delay indication indicating at least one of impossibility of establishing the connection to the server after the trigger or a data transmission delay.
Freezing tunnel for cooling and freezing individual food portions, comprising a freezing room in which food is frozen by means of cooled air, and a conveying device for moving the food through the freezing room, wherein the conveying device comprises an endless conveyor belt which is movable about a drive roll and reversing roller and has at least a top layer made of silicone material in which a number of flexible mould cavities are provided which are suitable for receiving an individual food portion, characterized in that the conveying device furthermore comprises a guide roller for the conveyor belt, which guide roller is situated between the drive roll and reversing roller, wherein the conveyor belt, after passing the guide roller, follows a downwardly directed course, wherein the freezing tunnel furthermore comprises a vibration device provided between the guide roller and the reversing roller on the downwardly directed course of the conveyor belt.
A process for producing a chewing gum composition containing a fat-free and gelatin-free chewing paste, comprising the following steps: 1) preparing the liquid phase, composed of starch and polyol syrups, 2) optionally, adding glycerol and/or emulsifier and/or flavorings, 3) introducing into the liquid phase thus obtained a powder fraction composed of non-cariogenic ingredients, and 4) introducing the gum base, characterized in that said process is carried out at a temperature of less than 100°C, preferably at a temperature of less than 90°C, in particular at a temperature of between 30-80°C, preferably between 50-80°C, for example at approximately 50°C, the weight ratio between the amount of water introduced by the polyol syrup and the amount of starch and/or of starch hydrolysate, in particular maltodextrin, is between 1 and 4, preferably between 1 and 2, more preferentially between 1 and 1.5. 1) preparing the liquid phase, composed of starch and polyol syrups, 2) optionally, adding glycerol and/or emulsifier and/or flavorings, 3) introducing into the liquid phase thus obtained a powder fraction composed of non-cariogenic ingredients, and 4) introducing the gum base,
An infrastructure equipment forming part of a wireless communications network, the infrastructure equipment configured to transmit data or receive data and comprising transceiver circuitry (802.1) configured to transmit signals and receive signals via a wireless access interface provided by the wireless communications network, and controller circuitry (802.2) configured in combination with the transceiver circuitry to transmit, to a communications device, a first control signal providing an indication of a set of downlink communications resources of the wireless access interface in which the infrastructure equipment is going to transmit a plurality of transport blocks to the communications device, wherein the plurality of transport blocks comprises a first plurality of transport blocks that are to be transmitted in a first set of downlink communications resources and a second plurality of transport blocks that are to be transmitted in a second set of downlink communications resources, the first set of downlink communications resources and the second set of downlink communications resources being separated in time by a scheduling gap formed by a third set of downlink communications resources of the wireless access interface, characterized in, that the infrastructure equipment is configured to transmit, to the communications device during the scheduling gap, a second control signal providing an indication of at least one change relating to the second plurality of transport blocks. transceiver circuitry (802.1) configured to transmit signals and receive signals via a wireless access interface provided by the wireless communications network, and controller circuitry (802.2) configured in combination with the transceiver circuitry to transmit, to a communications device, a first control signal providing an indication of a set of downlink communications resources of the wireless access interface in which the infrastructure equipment is going to transmit a plurality of transport blocks to the communications device, wherein the plurality of transport blocks comprises a first plurality of transport blocks that are to be transmitted in a first set of downlink communications resources and a second plurality of transport blocks that are to be transmitted in a second set of downlink communications resources, the first set of downlink communications resources and the second set of downlink communications resources being separated in time by a scheduling gap formed by a third set of downlink communications resources of the wireless access interface, characterized in, that the infrastructure equipment is configured to transmit, to the communications device during the scheduling gap, a second control signal providing an indication of at least one change relating to the second plurality of transport blocks.
A benefit agent delivery particle having a core-shell structure in which a porous shell of polymeric material entraps a core containing the benefit agent; in which the pores in the shell are at least partially occluded by a wash-removable coating provided at the exterior surface of the shell; and characterized in that the wash-removable coating is formed from deposited melamine/acid complex.