mhurhangee/ep-ind-claims huggingface dataset:
Measuring apparatus for an automatic liquid-handling laboratory apparatus for detecting the relative position of an end section of a pipetting container (50; 50') which can be moved automatically by the automatic laboratory apparatus, which consists partly or completely of plastic and which serves to hold a fluid laboratory sample by means of suction into the pipetting container and/or to dispense the fluid laboratory sample, having a holding device for holding the movable pipetting container (50; 50), which comprises a tubular container body (55; 55') with a first end section (51; 51') and a second end section (52; 52'), wherein the first end section is configured to connect the pipetting container to the holding device and comprises an auxiliary measuring section (54; 54'), and wherein the second end section comprises an end portion (56; 56') configured as a mouth region with a fluid exchange opening, an electronic control device with a data storage device for storing data, characterized in that the measuring apparatus comprises a first measuring device (10; 60) which is set up to measure a position, in particular a rotational position, of the auxiliary measuring section of the pipetting container on the holding device, and a second measuring device (20; 120; 120') which is configured to measure the position of the mouth region of the pipetting container, and the measuring apparatus is configured to store the position of the mouth region as a function of the position of the auxiliary measuring section as relative position data in the data storage device, so that the position of the mouth region of the pipetting container is subsequently determinable by measuring the position of the auxiliary measuring section and from the relative position data. a holding device for holding the movable pipetting container (50; 50), which comprises a tubular container body (55; 55') with a first end section (51; 51') and a second end section (52; 52'), wherein the first end section is configured to connect the pipetting container to the holding device and comprises an auxiliary measuring section (54; 54'), and wherein the second end section comprises an end portion (56; 56') configured as a mouth region with a fluid exchange opening, an electronic control device with a data storage device for storing data, characterized in that the measuring apparatus comprises a first measuring device (10; 60) which is set up to measure a position, in particular a rotational position, of the auxiliary measuring section of the pipetting container on the holding device, and a second measuring device (20; 120; 120') which is configured to measure the position of the mouth region of the pipetting container, and the measuring apparatus is configured to store the position of the mouth region as a function of the position of the auxiliary measuring section as relative position data in the data storage device, so that the position of the mouth region of the pipetting container is subsequently determinable by measuring the position of the auxiliary measuring section and from the relative position data.
An isolated human monoclonal antibody or antigen binding fragment thereof, comprising: a heavy chain variable region comprising amino acids 26-33 (HCDR1), 51-60 (HCDR2), and 99-120 (HCDR3) of SEQ ID NO: 1; and a light chain variable region comprising amino acids 26-31 (LCDR1), 49-51 (LCDR2), and 88-99 (LCDR3) of SEQ ID NO: 2; wherein the heavy chain variable region comprises an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO: 1 and wherein the light chain variable region comprises an amino acid sequence at least 90% identical to the amino acid sequence set forth as SEQ ID NO: 2; wherein the antibody or antigen-binding fragment specifically binds to gp41 and neutralizes HIV-1. a heavy chain variable region comprising amino acids 26-33 (HCDR1), 51-60 (HCDR2), and 99-120 (HCDR3) of SEQ ID NO: 1; and a light chain variable region comprising amino acids 26-31 (LCDR1), 49-51 (LCDR2), and 88-99 (LCDR3) of SEQ ID NO: 2; wherein the heavy chain variable region comprises an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO: 1 and wherein the light chain variable region comprises an amino acid sequence at least 90% identical to the amino acid sequence set forth as SEQ ID NO: 2; wherein the antibody or antigen-binding fragment specifically binds to gp41 and neutralizes HIV-1.
An automotive electrical and electronic system (100a-h) comprising: a plurality of computing platforms (101, 102, 103, 104) coupled together in a ring network; a plurality of power and data center nodes (105a-d) coupled to the ring network, the power and data center nodes each including at least one sensor interface, a power interface, and at least one data interface, the sensor interface configured to receive sensor data from one or more sensors (106a-h, 107a-e, 108a-h, 109a-l), the data interface configured to transmit the sensor data into the ring network; and a plurality of power supply rings each coupled to a different power source (202a, 202b) or source system (201a, 201b), the plurality of power supply rings coupled to the computing platforms and the power and data center nodes. a plurality of computing platforms (101, 102, 103, 104) coupled together in a ring network; a plurality of power and data center nodes (105a-d) coupled to the ring network, the power and data center nodes each including at least one sensor interface, a power interface, and at least one data interface, the sensor interface configured to receive sensor data from one or more sensors (106a-h, 107a-e, 108a-h, 109a-l), the data interface configured to transmit the sensor data into the ring network; and a plurality of power supply rings each coupled to a different power source (202a, 202b) or source system (201a, 201b), the plurality of power supply rings coupled to the computing platforms and the power and data center nodes.
A double-camera drive device, wherein the double-camera drive device comprises: a first cover body and a second cover body, the first cover body and the second cover body being respectively provided with a lens accommodating cavity; a first photographing component and a second photographing component provided on the first cover body and the second cover body respectively, and the first photographing component and the second photographing component each comprising an upper spring, an upper cover, a lens support wound with a drive coil at an outer periphery, driving magnets and a lower spring, wherein the driving magnets comprise a left driving magnet provided on a left side of the first cover body, a right driving magnet provided on a right side of the second cover body and a middle driving magnet provided between the first cover body and the second cover body; and a first Hall detection component provided on the first cover body and the first photographing component and a second Hall detection component provided on the second cover body and the second photographing component, the first Hall detection component and the second Hall detection component each comprising a Hall gasket and a Hall magnet provided on the respective support, and a Printed Circuit Board, PCB, component, each of the PCB components comprising a PCB board provided at one side of the respective cover body, as well as a Hall chip, a capacitor, pins and an internal circuit provided on the PCB board. a first cover body and a second cover body, the first cover body and the second cover body being respectively provided with a lens accommodating cavity; a first photographing component and a second photographing component provided on the first cover body and the second cover body respectively, and the first photographing component and the second photographing component each comprising an upper spring, an upper cover, a lens support wound with a drive coil at an outer periphery, driving magnets and a lower spring, wherein the driving magnets comprise a left driving magnet provided on a left side of the first cover body, a right driving magnet provided on a right side of the second cover body and a middle driving magnet provided between the first cover body and the second cover body; and a first Hall detection component provided on the first cover body and the first photographing component and a second Hall detection component provided on the second cover body and the second photographing component, the first Hall detection component and the second Hall detection component each comprising a Hall gasket and a Hall magnet provided on the respective support, and a Printed Circuit Board, PCB, component, each of the PCB components comprising a PCB board provided at one side of the respective cover body, as well as a Hall chip, a capacitor, pins and an internal circuit provided on the PCB board.
Boom of a piece of agricultural equipment, in particular a spreader boom of a crop sprayer, having a plurality of portions (4, 6, 8, 9), which are connected for pivoting action via joints (3, 5, 7, 9) more or less perpendicular to the ground, are each designed in a manner of upright lattice beams, are fitted on either side of a central boom part and can be adjusted by means of actuating elements between an outwardly folded-out boom-operating position, in which the portions are aligned approximately transversely to the operating direction and more or less parallel to the ground, and a zigzag-folded boom-transporting position, which is oriented approximately in the operating direction and in which portions are placed parallel one on the other, characterized in that, starting from the central boom part, at least two portions (4, 6, 8), which follow one after the other via the respective joint (5, 7), are stiffened in each case by at least one transverse limb, which is approximately parallel to the ground and projects in relation to a top boom side of the portion, and in that, in the boom-operating position, the transverse limbs of the two portions (4, 6; 6, 8) project, as seen with respect to the joint (5; 7) in relation to the mutually remote top sides of the two portions and at different height levels such that the transverse limbs can be guided past one another, into the boom-transporting position, for nesting purposes.
A method for the prevention of the reduction of a disulfide bond in a polypeptide expressed in a recombinant host cell during processing following fermentation, comprising, following fermentation, supplementing the pre-harvest cell culture fluid or harvested cell culture fluid (HCCF) of said recombinant host cell with a thioredoxin inhibitor, wherein said thioredoxin inhibitor is: (i) a direct inhibitor of thioredoxin; (ii) a specific inhibitor of thioredoxin reductase; (iii) is cupric sulfate; (a) added in a concentration between about 5 μM and about 100 μM; (b) added in a concentration between about 10 μM to about 80 μM; (c) added in a concentration between about 15 μM and about 50 μM; or (d) added at a concentration at least about two-times of thioredoxin concentration in said pre-harvest or harvested culture fluid. (iv) an inhibitor of G6PD, selected from the group consisting of pyridoxal 5'-phosphate, 1 fluoro-2,4 dinitrobenzene, dehydroepiandrosterone (DHEA) and epiandrosterone; (v) an inhibitor of hexokinase activity, which inhibitor is (a) a chelator of metal ions; or (b) selected from the group consisting of sorbose-1-phosphate, polyphosphates, 6-deoxy-6-fluoroglucose, 2-C-hydroxy-methylglucose, xylose, and lyxose; (vi) an antibody specifically binding to a thioredoxin reductase; or (vii) a measure indirectly resulting in the inhibition of thioredoxin activity, which measure is air sparging the harvested culture fluid of said recombinant host cell. (i) a direct inhibitor of thioredoxin; (ii) a specific inhibitor of thioredoxin reductase; (iii) is cupric sulfate; (a) added in a concentration between about 5 μM and about 100 μM; (b) added in a concentration between about 10 μM to about 80 μM; (c) added in a concentration between about 15 μM and about 50 μM; or (d) added at a concentration at least about two-times of thioredoxin concentration in said pre-harvest or harvested culture fluid. (a) added in a concentration between about 5 μM and about 100 μM; (b) added in a concentration between about 10 μM to about 80 μM; (c) added in a concentration between about 15 μM and about 50 μM; or (d) added at a concentration at least about two-times of thioredoxin concentration in said pre-harvest or harvested culture fluid. (iv) an inhibitor of G6PD, selected from the group consisting of pyridoxal 5'-phosphate, 1 fluoro-2,4 dinitrobenzene, dehydroepiandrosterone (DHEA) and epiandrosterone; (v) an inhibitor of hexokinase activity, which inhibitor is (a) a chelator of metal ions; or (b) selected from the group consisting of sorbose-1-phosphate, polyphosphates, 6-deoxy-6-fluoroglucose, 2-C-hydroxy-methylglucose, xylose, and lyxose; (vi) an antibody specifically binding to a thioredoxin reductase; or (vii) a measure indirectly resulting in the inhibition of thioredoxin activity, which measure is air sparging the harvested culture fluid of said recombinant host cell.
A method at an authentication server for multi-factor authentication of a user of an electronic device, wherein the multi-factor authentication comprises a first authentication of the electronic device and a second authentication based on a further authentication factor associated with the user, the method comprising: receiving at the authentication server a request for the first authentication of the electronic device; in response to receiving the request for the first authentication of the electronic device, sending information to the electronic device; receiving a response based on the information sent to the electronic device, wherein the response includes an authentication time limit; authenticating the electronic device based on the received response; and storing the authentication time limit upon authenticating the electronic device to allow subsequent completion of the multi-factor authentication by completing the second authentication within the authentication time limit. receiving at the authentication server a request for the first authentication of the electronic device; in response to receiving the request for the first authentication of the electronic device, sending information to the electronic device; receiving a response based on the information sent to the electronic device, wherein the response includes an authentication time limit; authenticating the electronic device based on the received response; and storing the authentication time limit upon authenticating the electronic device to allow subsequent completion of the multi-factor authentication by completing the second authentication within the authentication time limit.
A method performed by a station, STA, to receive a frame in a wireless local area network, WLAN, system, the method comprising: receiving, at the STA, the frame comprising a signaling, SIG, field for control information and a data field for data, wherein the SIG field comprises a first SIG field, SIG A and a second SIG field, SIG B, wherein the control information of the SIG A includes a bandwidth field, a field for guard interval, GI, length, and a basic service set, BSS, color field, wherein the control information of the SIG B includes user specific information; and processing the bandwidth field within the SIG A, wherein the STA identifies a bandwidth of 20 MHz, 40 MHz, 80 MHz and 160 MHz or 80+80 MHz based on a value of the bandwidth field, if the STA determines the value of the bandwidth field is within a first range of values available for the bandwidth field, wherein the STA identifies a presence of one or more null channels based on a value of the bandwidth field, if the STA determines the value of the bandwidth field is within a second range of values available for the bandwidth field, and wherein the first range of values do not overlap with the second range of values. receiving, at the STA, the frame comprising a signaling, SIG, field for control information and a data field for data, wherein the SIG field comprises a first SIG field, SIG A and a second SIG field, SIG B, wherein the control information of the SIG A includes a bandwidth field, a field for guard interval, GI, length, and a basic service set, BSS, color field, wherein the control information of the SIG B includes user specific information; and processing the bandwidth field within the SIG A, wherein the STA identifies a bandwidth of 20 MHz, 40 MHz, 80 MHz and 160 MHz or 80+80 MHz based on a value of the bandwidth field, if the STA determines the value of the bandwidth field is within a first range of values available for the bandwidth field, wherein the STA identifies a presence of one or more null channels based on a value of the bandwidth field, if the STA determines the value of the bandwidth field is within a second range of values available for the bandwidth field, and wherein the first range of values do not overlap with the second range of values.
Apramycin of formula, or an acid addition salt thereof; or an apramycin derivative of formula, wherein - one or more amino groups are alkylated, cycloalkylated, alkenylated and/or acylated, or replaced by a hydroxy group, and/or - one or more hydroxy groups are alkylated, alkenylated, acylated, and/or replaced by an amino group, and/or - two neighbouring hydroxy groups are cyclized to form an acetal or a carbonate, and/or - a neighbouring hydroxy group and amino group are cyclized to form an aminoacetal or a carbamate, and/or - the 7'-NHCH 3 group is replaced by an amino group NH 2, an alkylated, cycloalkylated, alkenylated and/or acylated amino group, a hydroxy group, an alkylated, cycloalkylated, alkenylated or acetylated hydroxy group, and/or - the 3' carbon atom is substituted by an amino group NH 2 or an alkylated, cycloalkylated, alkenylated and/or acylated amino group, or by a hydroxy group OH or an alkylated, alkenylated or acylated hydroxy group, and/or - the 5 and/or the 6 hydroxy group is glycosylated by a monosaccharide, and/or - ring I or ring III is replaced by a different monosaccharide; or a pharmaceutically acceptable acid addition salt thereof; for use in the treatment of bacterial infectious diseases in humans. - one or more amino groups are alkylated, cycloalkylated, alkenylated and/or acylated, or replaced by a hydroxy group, and/or - one or more hydroxy groups are alkylated, alkenylated, acylated, and/or replaced by an amino group, and/or - two neighbouring hydroxy groups are cyclized to form an acetal or a carbonate, and/or - a neighbouring hydroxy group and amino group are cyclized to form an aminoacetal or a carbamate, and/or - the 7'-NHCH 3 group is replaced by an amino group NH 2, an alkylated, cycloalkylated, alkenylated and/or acylated amino group, a hydroxy group, an alkylated, cycloalkylated, alkenylated or acetylated hydroxy group, and/or - the 3' carbon atom is substituted by an amino group NH 2 or an alkylated, cycloalkylated, alkenylated and/or acylated amino group, or by a hydroxy group OH or an alkylated, alkenylated or acylated hydroxy group, and/or - the 5 and/or the 6 hydroxy group is glycosylated by a monosaccharide, and/or - ring I or ring III is replaced by a different monosaccharide;
Seat (101, 102, 103) having a seat-adjusting mechanism for a person to enter into and exit from an interior of a motor vehicle more easily, wherein a backrest part is positively coupled via a swing arm to a seat part so that an adjustment movement of the backrest part is transmitted to the seat part, characterized in that the backrest part and the seat part of the seat (101, 102, 103) are displaced in a first step, starting from a starting position, into an intermediate position by a first, predeterminable, horizontal linear measure (Δ×1) by means of a displacement device (400; 400-1, 400-2, 400-3) connected to an upper rail of a seat rail, wherein the backrest part is rigidly connected to a backrest unlocking unit of the backrest part via a coupling element pivotable about a first coupling element pivot axis (y10a) with respect to the displacement device (400; 400-1, 400-2, 400-3), wherein the coupling element is always coupled to the displacement device (400; 400-1, 400-2, 400-3) and thus to the upper rail, whereby the backrest part is displaced in the longitudinal direction (+x) along a first, predeterminable, horizontal, backrest-part adjustment path (Δ×1a), and, at the same time, the inclination of the backrest part is displaced from its starting position to its intermediate position at a predeterminable angle (α), wherein the positively-coupled seat part supported on a pivot arm directly or indirectly on the upper rail of the seat rail is displaced in the first step along a first, horizontal, seat-part adjustment path (Δ×1b) in the longitudinal direction (+x), and, simultaneously, a front side of the seat part is lowered along a vertical adjustment path (Δz), whereupon the backrest part and the seat part together are simultaneously displaced further in the longitudinal direction (+x) along a predeterminable, second, horizontal adjustment path (Δ×2) into an easy-entry position in a second step by unlocking the upper rail relative to a lower rail, affixed to the bodywork, of the seat rail.
A corner bracket for a window blind frame, the corner bracket including a central body portion and extending from the central body portion a first connector and a second connector, wherein the second connector is angled relative to the first connector; each connector includes a locating arm, a friction plate and a stop surface; wherein each friction plate defines a pair of opposed surfaces (18, 20) and each surface carries thereon a respective outwardly projecting deformable rib (22, 24); wherein each locating arm further includes at least one further outwardly projecting deformable rib (26, 28); and wherein each friction plate is spaced from the respective locating arm to define a gap between the friction plate and the locating arm.
A method of diagnosing a thyroid disease in a human subject using recombinant cynomolgus monkey thyroid peroxidase (cm-rTPO) of SEQ ID NO: 1, the method comprising: a) incubating a biological sample that had been obtained from the subject with: an unlabeled recombinant cynomolgus monkey thyroid peroxidase (rTPO) comprising the amino acid sequence of SEQ ID NO: 1 directly or indirectly linked to a solid support, and a labeled cynomolgus monkey rTPO comprising the amino acid sequence of SEQ ID NO: 1; b) detecting the presence or absence of a complex comprising the labeled cynomolgus monkey rTPO, an anti-thyroid peroxidase antibody, and the solid support, wherein the presence of the complex indicates the presence of the anti-thyroid peroxidase antibody in the biological sample; and c) diagnosing the subject with the thyroid disease when the complex is formed. a) incubating a biological sample that had been obtained from the subject with: an unlabeled recombinant cynomolgus monkey thyroid peroxidase (rTPO) comprising the amino acid sequence of SEQ ID NO: 1 directly or indirectly linked to a solid support, and a labeled cynomolgus monkey rTPO comprising the amino acid sequence of SEQ ID NO: 1; an unlabeled recombinant cynomolgus monkey thyroid peroxidase (rTPO) comprising the amino acid sequence of SEQ ID NO: 1 directly or indirectly linked to a solid support, and a labeled cynomolgus monkey rTPO comprising the amino acid sequence of SEQ ID NO: 1; b) detecting the presence or absence of a complex comprising the labeled cynomolgus monkey rTPO, an anti-thyroid peroxidase antibody, and the solid support, wherein the presence of the complex indicates the presence of the anti-thyroid peroxidase antibody in the biological sample; and c) diagnosing the subject with the thyroid disease when the complex is formed.