A compound of Formula: wherein X is selected from a covalent bond, S, and O; Y is S or O; Z is O or CH 2, provided when Y is O, then Z is O; R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 1-3 alkoxy, halo, and NR a R b wherein R a and R b are independently H or C 1-3 alkyl; R 3 and R 4 are independently selected from H, halo, cyano, C 1-5 alkyl, hydroxy, C 2-4 acyl, C 1-4 alkoxy, and NR c R d wherein R c and R d are independently H or C 1-3 alkyl, provided that R 3 and R 4 are not both H; R 5 and R 6 are independently selected from H, C 1-8 alkyl and substituted C 1-8 alkyl, provided that R 5 and R 6 are not both H; R 7 is selected from H, halo, C 1-8 alkyl, and phenyl; R 8 and R 9 together form C 1-9 alkylidenyl or C 3-9 alkenylidenyl; or R 8, R 9 and the carbon atom to which they are attached together form C 3-7 cycloalkyl; n is 0, 1 or 2; and m is 0, 1 or 2; or a pharmaceutically acceptable salt thereof, wherein "alkyl" and "alkoxy" are optionally substituted with one or more substituents independently selected from: halogen; hydroxy; amino; alkoxyl; nitro; alkyl; cyano; phenyl; heteroaryl; heterocyclyl; phenoxy; heteroaryloxy; heterocyclyloxy; thioalkyl; thiophenyl; and carboxyl; "alkenyl" is optionally substituted with one or more substituents independently selected from cyano- and thio-; and "aryl" is optionally substituted with one to three substituents independently selected from C 1 -C 8 alkyl; C 1 -C 8 alkoxy; fluorinated C 1 -C 8 alkyl; fluorinated C 1 -C 8 alkoxy; halogen; cyano; C 1 -C 8 alkylcarbonyl; carboxyl; hydroxy; amino; nitro; C 1 -C 4 alkylamino; C 1 -C 4 dialkylamino; and unsubstituted, mono-, di- or tri-substituted phenyl wherein the substituents on the phenyl are independently selected from C 1 -C 8 alkyl; C 1 -C 8 alkoxy; fluorinated C 1 -C 8 alkyl; fluorinated C 1 -C 8 alkoxy; halogen; cyano; acetyl; carboxyl; hydroxy; amino; nitro; alkylamino; dialkylamino and five or six membered heteroaryl having 1-3 heteroatoms selected from N, O and S; "heteroaryl" is optionally substituted with one to three substituents selected from C 1 -C 8 alkyl; halogen; and aryl. X is selected from a covalent bond, S, and O; Y is S or O; Z is O or CH 2, provided when Y is O, then Z is O; R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 1-3 alkoxy, halo, and NR a R b wherein R a and R b are independently H or C 1-3 alkyl; R 3 and R 4 are independently selected from H, halo, cyano, C 1-5 alkyl, hydroxy, C 2-4 acyl, C 1-4 alkoxy, and NR c R d wherein R c and R d are independently H or C 1-3 alkyl, provided that R 3 and R 4 are not both H; R 5 and R 6 are independently selected from H, C 1-8 alkyl and substituted C 1-8 alkyl, provided that R 5 and R 6 are not both H; R 7 is selected from H, halo, C 1-8 alkyl, and phenyl; R 8 and R 9 together form C 1-9 alkylidenyl or C 3-9 alkenylidenyl; or R 8, R 9 and the carbon atom to which they are attached together form C 3-7 cycloalkyl; n is 0, 1 or 2; and m is 0, 1 or 2; "alkyl" and "alkoxy" are optionally substituted with one or more substituents independently selected from: halogen; hydroxy; amino; alkoxyl; nitro; alkyl; cyano; phenyl; heteroaryl; heterocyclyl; phenoxy; heteroaryloxy; heterocyclyloxy; thioalkyl; thiophenyl; and carboxyl; halogen; hydroxy; amino; alkoxyl; nitro; alkyl; cyano; phenyl; heteroaryl; heterocyclyl; phenoxy; heteroaryloxy; heterocyclyloxy; thioalkyl; thiophenyl; and carboxyl; "alkenyl" is optionally substituted with one or more substituents independently selected from cyano- and thio-; and "aryl" is optionally substituted with one to three substituents independently selected from C 1 -C 8 alkyl; C 1 -C 8 alkoxy; fluorinated C 1 -C 8 alkyl; fluorinated C 1 -C 8 alkoxy; halogen; cyano; C 1 -C 8 alkylcarbonyl; carboxyl; hydroxy; amino; nitro; C 1 -C 4 alkylamino; C 1 -C 4 dialkylamino; and unsubstituted, mono-, di- or tri-substituted phenyl wherein the substituents on the phenyl are independently selected from C 1 -C 8 alkyl; C 1 -C 8 alkoxy; fluorinated C 1 -C 8 alkyl; fluorinated C 1 -C 8 alkoxy; halogen; cyano; acetyl; carboxyl; hydroxy; amino; nitro; alkylamino; dialkylamino and five or six membered heteroaryl having 1-3 heteroatoms selected from N, O and S; "heteroaryl" is optionally substituted with one to three substituents selected from C 1 -C 8 alkyl; halogen; and aryl.