mhurhangee/ep-ind-claims huggingface dataset:
A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof an effective amount of an active agent that suppresses miR-29a, having the sequence UAGCACCAUCUGAAAUCGGUUA (SEQ. ID. No.: 1), and/or miR-29b, having the sequence UAGCACCAUUUGAAAUCAGUGUU (SEQ. ID No.: 2), in a cosmetically acceptable vehicle, for a time sufficient to enhance the production of collagen, elastin, and/or fibrillin in the skin, characterized in that said active agent is a compound having the structure of formula I: where: R 1 and R 2 are independently hydrogen, -R, or -C(=O)R*, wherein R 1 and R 2 may together with the nitrogen atom to which they are attached form a three to six-membered ring; R 3 is selected from hydrogen, -R, -OR*, -SR*, and -N(R n)(R*); R 4 and R 5 are independently selected at each occurrence from hydrogen; -R; or X 1; and wherein any two adjacent groups R 5 may form a five- or six-membered ring fused to the benzene ring to which they are attached; R 6 is hydrogen, -R, or -C(=O)R*; R, R*, and R N are independently hydrogen or a C 1-20 hydrocarbon radical; wherein said C 1-20 hydrocarbon radical may optionally be substituted with a group X 1 and/or with from one to twelve heteroatoms selected from oxygen, nitrogen, and sulfur; X 1 is selected from the group consisting of -F; -Cl; -Br; -I; -OH; -C≡C-R*; -C≡N; - C =N-R N; -C=N-N(R N) 2; -C(=NR N)-N(R N) 2; -CH 2 OH; -CHO; -(C=O)-R*; -CO 2 H; - CO 2 -; -CO 2 R*: -CS 2 R*; -(C=O)-S-R*; -S-(C=O)-R*; -(C=O)-NH 2; -(C=O)-NR N R N; - (C=O)-NHNH 2; -O-(C=O)-NHNH 2; -(C=S)-NH 2; -(C=S)-N(R N) 2; -O-(C=O)-H; -O-(C=O)-R*; -O-(C=O)-NH 2; -O-(C=O)-NR N R N; -OR*; -SR*; -NH 2; -NHR N; -NR N 2; - N(R N) 3 +; -N(R N)-OH; -N(→O)(R*) 2; -O-N(R N) 2; -N(R N)-O-R*; -N(R N)-N(R N) 2; - NR N -(C=O)-R*; NR N C(=O)O-R*; -NR N -CHO; -NR N -(C=O)-R*; -NR N C(=O)NR N; - N(R N)-C(=O)-N(R N) 2; -N(R N)-C(=S)-N(R N) 2; -N=C(R*) 2; -N=N-R N; -SCN; NCS; -NSO; -SS-R*; -SO-R*; -SO 2 -R*; -O-S(=O) 2 R*; -S(=O) 2 OR*; -N(R N)-SO 2 -R*; -SO 2 -N(R*) 2; -O-SO 3 -; -O-S(=O) 2 -OR*; -O-S(=O)-OR*; -O-S(=O)-R*; -S(=O)-OR*; -S(=O)-R*; NO; -NO 2; NO 3; -O-NO; -O-NO 2; -N 3; -N 2; -N(C 2 H 4); -Si(R*) 3; - CF 3; -O-CF 3, -(C=O)-R*; -P(R*) 2; -O-P(=O)(OR*) 2; and -P(=O)(OR*) 2; "n" is an integer from 0 to 3, and, in the case where "n" is 2 or 3, R 5 is independently selected at each occurrence; and cosmetically acceptable acid addition salts thereof.
A method of refueling a pressurized water nuclear reactor having a pressure vessel; an upper removable head for sealably engaging an upper opening in the pressure vessel; a core having an axial dimension supported within the pressure vessel; a plurality of nuclear fuel assemblies supported within the core, at least two of the fuel assemblies having at least one instrumentation thimble extending axially therethrough; an upper internals assembly supported above the core and having axially extending instrumentation guide paths supported therethrough with each of the instrumentation thimbles that are configured to receive instrumentation through the upper internals assembly being aligned with one of the instrumentation guide paths; the upper internals assembly including an instrumentation grid assembly plate supported above and axially movable relative to a lower portion of the upper internals; at least two in-core instrumentation thimble assemblies respectively extending through a corresponding one of the instrumentation guide paths into a corresponding one of the instrumentation thimbles and retractable into the upper internals assembly when the instrumentation grid assembly plate is raised; each of the in- core instrumentation thimble assemblies having a signal output lead that is routed within the vicinity of the instrumentation grid plate to and through a penetration flange that fits between the removable head and the pressure vessel; and an electrical connector that connects each of the signal output leads from the at least two in-core instrumentation assemblies to an output cable that extends through the penetration flange to the exterior of the pressure vessel, the method comprising the steps of: lowering a water level in the pressure vessel below the penetration flange; removing the upper removable head from the penetration flange; axially raising the instrumentation grid assembly plate until the instrumentation thimble assemblies are above the core; exposing the core by removing the upper internals assembly; and refueling the core, characterized by lowering the water level in the pressure vessel below the electrical connector; and disconnecting the electrical connector which simultaneously disconnects each of the signal output leads associated with the at least two in-core instrumentation thimble assemblies from the penetration flange prior to axially raising the instrumentation grid assembly plate. lowering a water level in the pressure vessel below the penetration flange; removing the upper removable head from the penetration flange; axially raising the instrumentation grid assembly plate until the instrumentation thimble assemblies are above the core; exposing the core by removing the upper internals assembly; and refueling the core, characterized by lowering the water level in the pressure vessel below the electrical connector; and disconnecting the electrical connector which simultaneously disconnects each of the signal output leads associated with the at least two in-core instrumentation thimble assemblies from the penetration flange prior to axially raising the instrumentation grid assembly plate.
A sound processor assembly with an electromagnetic coil with an adjustable orientation adapted for an electromagnetic hearing implant comprising: a) a rigid shell made from a first polymer which is formed to the shape of an ear canal of an intended user to support the sound processor assembly and which is not deformed when heated to a temperature which softens and deforms a second polymer; b) a coil support material made from the second polymer which will deform when heated and is rigid at room temperature, the coil support material defining a second polymer portion connected to the rigid shell; and c) the electromagnetic coil which is supported by and contained within the second polymer portion. a) a rigid shell made from a first polymer which is formed to the shape of an ear canal of an intended user to support the sound processor assembly and which is not deformed when heated to a temperature which softens and deforms a second polymer; b) a coil support material made from the second polymer which will deform when heated and is rigid at room temperature, the coil support material defining a second polymer portion connected to the rigid shell; and c) the electromagnetic coil which is supported by and contained within the second polymer portion.
A rasterizer in a graphic processor device implemented on a field programmable gate array circuitry, comprising: a preprocessor that creates data packets to generate at least one line; a main module that generates a stream of data fragments that become pixels; wherein the main module is based upon a multi-threading packet processing engine; and a postprocessor that combines the data fragments and pipeline commands into one output to a fragment processor. a preprocessor that creates data packets to generate at least one line; a main module that generates a stream of data fragments that become pixels; wherein the main module is based upon a multi-threading packet processing engine; and a postprocessor that combines the data fragments and pipeline commands into one output to a fragment processor.
Method for processing acceleration data (Da) outputted by an acceleration sensor in a housing (7, 71), the method comprising the steps of: repeatedly acquiring the acceleration data (Da) from the acceleration sensor, characterized in that it further comprises: an acceleration determining step (S82 to S89) for determining whether the acquired acceleration data represent an acceleration with an acceleration magnitude data (Dd) or a deceleration with a deceleration magnitude data (De) of the housing in a predetermined direction, and a step of calculating a moving direction (dir) of the housing by using the determined deceleration magnitude data (De). repeatedly acquiring the acceleration data (Da) from the acceleration sensor, characterized in that it further comprises: an acceleration determining step (S82 to S89) for determining whether the acquired acceleration data represent an acceleration with an acceleration magnitude data (Dd) or a deceleration with a deceleration magnitude data (De) of the housing in a predetermined direction, and a step of calculating a moving direction (dir) of the housing by using the determined deceleration magnitude data (De). an acceleration determining step (S82 to S89) for determining whether the acquired acceleration data represent an acceleration with an acceleration magnitude data (Dd) or a deceleration with a deceleration magnitude data (De) of the housing in a predetermined direction, and a step of calculating a moving direction (dir) of the housing by using the determined deceleration magnitude data (De).
A process for manufacturing a part including a formation of successive solid metal layers (20 1... 20 n), superposed on one another, each layer describing a pattern defined from a numerical model, each layer being formed by the deposition of a metal, referred to as filler metal, the filler metal being subjected to an input of energy so as to melt and form, by solidifying, said layer, wherein the filler metal takes the form of a powder, the exposure of which to an energy beam results in melting followed by a solidification so as to form a solid layer (20 1...20 n), the process being characterised in that the filler metal is an aluminium alloy comprising at least the following alloying elements: - Si, in a weight fraction of from 4% to 20%; - Fe, in a weight fraction of from 2% to 15% optionally at least one element selected from: - Mn, in a weight fraction of from 0.1% to 5%; - Ti, in a weight fraction of from 0.01% to 5%; - V, in a weight fraction of from 0.1% to 5%; - Zr, in a weight fraction of from 0.05% to 5%; - Cr, in a weight fraction of from 0.05% to 5%; - Hf, in a weight fraction of from 0.05% to 5%; optionally at least one element selected from: - Ag, in a weight fraction of 0.1 to 1%; - Li, in a weight fraction of from 0.1 to 2%; - Zn, in a weight fraction of from 0.1 to 1%; optionally the element Mg in a weight fraction of from 0.1 to 7%; optionally at least one element selected from W, Nb, Ta, Y, Yb, Nd, Er, with a weight fraction of at least 0.1% and at most 5%; optionally at least one element selected from Co and Ni with a weight fraction of at least 0.1% and at most 7%; optionally at least one element selected from La, Ce or mischmetal, with a weight fraction of at least 0.1% and at most 12%; optionally at least one element selected from Bi, Sr, Ba, Ca, Sb, P and B, with a weight fraction of at least 0.01% and at most 1%; a weight fraction of other elements or impurities less than 0.05%, the cumulative weight fraction of other elements or impurities being less than 0.15%; remains aluminium. - Si, in a weight fraction of from 4% to 20%; - Fe, in a weight fraction of from 2% to 15% optionally at least one element selected from: - Mn, in a weight fraction of from 0.1% to 5%; - Ti, in a weight fraction of from 0.01% to 5%; - V, in a weight fraction of from 0.1% to 5%; - Zr, in a weight fraction of from 0.05% to 5%; - Cr, in a weight fraction of from 0.05% to 5%; - Hf, in a weight fraction of from 0.05% to 5%; - Ag, in a weight fraction of 0.1 to 1%; - Li, in a weight fraction of from 0.1 to 2%; - Zn, in a weight fraction of from 0.1 to 1%;
Piste grooming vehicle for preparing a ski piste, having - a track drive, - a snow blower arranged at the rear of the piste grooming vehicle and controllable with regard to at least one variable function parameter by a vehicle operator, - a computer unit for controlling the snow blower and - a display screen connected to the computer unit and arranged inside a vehicle operator cab of the piste grooming vehicle, where the computer unit is designed to display on the display screen status information on the variable function parameters of the snow blower, characterized in that the computer unit is designed to display on the display screen in a first display mode a snow blower display in a three-dimensional or perspective manner, where at least two function parameters of the snow blower independent of one another are displayed in the snow blower display and where the computer unit is designed to display the function parameters with regard to the position of the snow blower in that, in the snow blower display, the position of the displayed snow blower matches the position of the snow blower attached to the piste grooming vehicle. - a track drive, - a snow blower arranged at the rear of the piste grooming vehicle and controllable with regard to at least one variable function parameter by a vehicle operator, - a computer unit for controlling the snow blower and - a display screen connected to the computer unit and arranged inside a vehicle operator cab of the piste grooming vehicle,
Bearing unit for a vehicle wheel, the bearing unit having an axis of rotation and comprising: - a radially outer stationary ring provided with a tubular axial lug delimited by an outer cylindrical surface, and with a flange transverse to the axis of rotation and axially delimited, on the side where the axial lug is located, by an axial front surface; - a radially inner rotatable ring defining, together with the stationary ring, a space; - an encoder fixed onto the inner ring and extending outside of the space and in front of the axial lug; and - a protective cover mounted on the axial lug so as to protect the encoder and close off the space and comprising a side wall mounted on the outer cylindrical surface; and wherein - the stationary ring comprises a shaped annular channel formed across the axial surface and delimited axially by a bottom surface; - the side wall of the cover is provided with a bent edge arranged axially in abutment against the bottom surface of the annular channel; - the bearing unit also comprises sealing means arranged between the bent edge and the bottom surface so as to seal in a leak-tight manner the annular channel, preventing the infiltration of impurities between the cover and the axial lug. - a radially outer stationary ring provided with a tubular axial lug delimited by an outer cylindrical surface, and with a flange transverse to the axis of rotation and axially delimited, on the side where the axial lug is located, by an axial front surface; - a radially inner rotatable ring defining, together with the stationary ring, a space; - an encoder fixed onto the inner ring and extending outside of the space and in front of the axial lug; and - a protective cover mounted on the axial lug so as to protect the encoder and close off the space and comprising a side wall mounted on the outer cylindrical surface; and wherein - the stationary ring comprises a shaped annular channel formed across the axial surface and delimited axially by a bottom surface; - the side wall of the cover is provided with a bent edge arranged axially in abutment against the bottom surface of the annular channel; - the bearing unit also comprises sealing means arranged between the bent edge and the bottom surface so as to seal in a leak-tight manner the annular channel, preventing the infiltration of impurities between the cover and the axial lug.
A system comprising: at least one processing unit (1010, 1185); and at least one memory (1015, 1145) storing computer executable instructions that, when executed by the at least one processing unit, cause the system to provide a user interface for a collaborative workspace environment (140, 1005), the user interface comprising: a first canvas associated with an entity provided by a service in the collaborative workspace environment; a set of commenting tools that enable comments to be provided about the entity; and a second canvas for displaying a representation of the entity and for providing a conversation area for the entity, wherein comments made in the first canvas are reflected in the conversation area of the second canvas and wherein comments made in the conversation area of the second canvas are reflected in the first canvas. at least one processing unit (1010, 1185); and at least one memory (1015, 1145) storing computer executable instructions that, when executed by the at least one processing unit, cause the system to provide a user interface for a collaborative workspace environment (140, 1005), the user interface comprising: a first canvas associated with an entity provided by a service in the collaborative workspace environment; a set of commenting tools that enable comments to be provided about the entity; and a second canvas for displaying a representation of the entity and for providing a conversation area for the entity, wherein comments made in the first canvas are reflected in the conversation area of the second canvas and wherein comments made in the conversation area of the second canvas are reflected in the first canvas. a first canvas associated with an entity provided by a service in the collaborative workspace environment; a set of commenting tools that enable comments to be provided about the entity; and a second canvas for displaying a representation of the entity and for providing a conversation area for the entity, wherein comments made in the first canvas are reflected in the conversation area of the second canvas and wherein comments made in the conversation area of the second canvas are reflected in the first canvas.
A powdered material for additive manufacturing, having a d 50 -value ranging between 10 and 100 μm, as measured by laser scattering in isopropanol, comprising: - one polymeric component comprising at least one poly(arylene sulfide) polymer, comprising recurring units p, q and r according of formula, and: wherein ▪ n p, n q and n r are respectively the mole % of each recurring units p, q and r; ▪ recurring units p, q and r are arranged in blocks, in alternation or random ly; ▪ 1 % ≤ n q + n r / n p + n q + n r ≤ 12 %; ▪ n q is ≥ 0% and n r is ≥ 0%; ▪ j is zero or an integer varying between 1 and 4; ▪ R 1 is selected from the group consisting of halogen atoms, C 1 -C 12 alkyl groups, C 7 -C 24 alkylaryl groups, C 7 -C 24 aralkyl groups, C 6 -C 24 arylene groups, C 1 -C 12 alkoxy groups, and C 6 -C 18 aryloxy groups, - optionally one or several flow agent(s), - optionally one or several additive(s) selected from the group consisting of lubricants, heat stabilizers, light stabilizers, antioxidants, pigments, processing aids, dyes, fillers, nanofillers or electromagnetic absorbers and flame retardants. - one polymeric component comprising at least one poly(arylene sulfide) polymer, comprising recurring units p, q and r according of formula, and: wherein ▪ n p, n q and n r are respectively the mole % of each recurring units p, q and r; ▪ recurring units p, q and r are arranged in blocks, in alternation or random ly; ▪ 1 % ≤ n q + n r / n p + n q + n r ≤ 12 %; ▪ n q is ≥ 0% and n r is ≥ 0%; ▪ j is zero or an integer varying between 1 and 4; ▪ R 1 is selected from the group consisting of halogen atoms, C 1 -C 12 alkyl groups, C 7 -C 24 alkylaryl groups, C 7 -C 24 aralkyl groups, C 6 -C 24 arylene groups, C 1 -C 12 alkoxy groups, and C 6 -C 18 aryloxy groups, ▪ n p, n q and n r are respectively the mole % of each recurring units p, q and r; ▪ recurring units p, q and r are arranged in blocks, in alternation or random ly; ▪ 1 % ≤ n q + n r / n p + n q + n r ≤ 12 %; ▪ n q is ≥ 0% and n r is ≥ 0%; ▪ j is zero or an integer varying between 1 and 4; ▪ R 1 is selected from the group consisting of halogen atoms, C 1 -C 12 alkyl groups, C 7 -C 24 alkylaryl groups, C 7 -C 24 aralkyl groups, C 6 -C 24 arylene groups, C 1 -C 12 alkoxy groups, and C 6 -C 18 aryloxy groups, - optionally one or several flow agent(s), - optionally one or several additive(s) selected from the group consisting of lubricants, heat stabilizers, light stabilizers, antioxidants, pigments, processing aids, dyes, fillers, nanofillers or electromagnetic absorbers and flame retardants.
Liquid-crystalline medium, characterised in that it comprises one or more compounds of the formula I, in which X denotes F, Cl, CN, OCN, SF 5, a fluorinated alkyl radical having 1-6 C atoms, a fluorinated alkoxy radical having 1-6 C atoms, a fluorinated alkenyl radical having 2-6 C atoms, a fluorinated alkylalkoxy radical having 1-6 C atoms, L 1-4 each, independently of one another, denote H or F, alkenyl denotes an alkenyl radical having 2-6 C atoms, and additionally one or more compounds of the formulae II and/or III, in which A denotes 1,4-phenylene or trans-1,4-cyclohexylene, a denotes 0 or 1, R 3 denotes alkenyl having 2 to 9 C atoms, and R 4 denotes a straight-chain alkyl radical having 1 to 12 C atoms or alkenyl radical having 2 to 9 C atoms. X denotes F, Cl, CN, OCN, SF 5, a fluorinated alkyl radical having 1-6 C atoms, a fluorinated alkoxy radical having 1-6 C atoms, a fluorinated alkenyl radical having 2-6 C atoms, a fluorinated alkylalkoxy radical having 1-6 C atoms, L 1-4 each, independently of one another, denote H or F, alkenyl denotes an alkenyl radical having 2-6 C atoms, A denotes 1,4-phenylene or trans-1,4-cyclohexylene, a denotes 0 or 1, R 3 denotes alkenyl having 2 to 9 C atoms, and R 4 denotes a straight-chain alkyl radical having 1 to 12 C atoms or alkenyl radical having 2 to 9 C atoms.
A device for controlling the rate of flow of a liquid in a flexible tube, comprising two opposed surfaces (11, 12) between which the tube is received in use, wherein the surfaces (11, 12) are elongated in the direction of flow of the liquid in the tube such that the length of the opposed surfaces (11, 12) in contact with the tube in use is at least five times greater than the internal diameter of the tube, those portions of the opposed surfaces (11, 12) which contact the tube in use are flat, and the opposed surfaces (11, 12) are arranged with a variable included angle (α) between them, so that the opposed surfaces (11, 12) can be arranged parallel to one another and in use the included angle (α) does not exceed 40°, and a means for varying the distance between the surfaces (11, 12) are provided so as to compress the tube between them by the desired amount, characterized in that the opposed surfaces (11, 12) are hinged along one long edge and each provided with an aperture in the free long edge and the means comprises a screw so that the ends of the screw can be received in the apertures.