mhurhangee/ep-ind-claims huggingface dataset:
A method of producing an anti-CLDN6 antibody that specifically binds to CLDN6 associated with the surface of a cell that expresses CLDN6, wherein the antibody mediates killing of cells by inducing ADCC and/or CDC, the method comprising the steps of: a. culturing a host cell transformed with one or more expression vectors encoding the antibody under conditions in which the host cell expresses the antibody; and b. harvesting a preparation of the antibody or an antigen binding fragment thereof expressed by the host cell; wherein the antibody expressed by the host cell is an antibody that is capable of discriminating between CLDN6 on the surface of a cell that expresses CLDN6 and a CLDN6 mutant on the surface of a cell that expresses said CLDN6 mutant, wherein said CLDN6 mutant comprises an alanine mutation at position 35, 37 or 39 of the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 8, wherein the antibody comprises an antibody heavy chain comprising the CDR3 sequence Xaa1 Gly Xaa2 Val Xaa3, wherein Xaa1 is an aromatic amino acid, Xaa2 is an aromatic amino acid, and Xaa3 is Leu or Phe. a. culturing a host cell transformed with one or more expression vectors encoding the antibody under conditions in which the host cell expresses the antibody; and b. harvesting a preparation of the antibody or an antigen binding fragment thereof expressed by the host cell; wherein the antibody expressed by the host cell is an antibody that is capable of discriminating between CLDN6 on the surface of a cell that expresses CLDN6 and a CLDN6 mutant on the surface of a cell that expresses said CLDN6 mutant, wherein said CLDN6 mutant comprises an alanine mutation at position 35, 37 or 39 of the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 8, wherein the antibody comprises an antibody heavy chain comprising the CDR3 sequence Xaa1 Gly Xaa2 Val Xaa3, wherein Xaa1 is an aromatic amino acid, Xaa2 is an aromatic amino acid, and Xaa3 is Leu or Phe.
A hybrid work machine comprising: - an engine; - a motor generator for generating electricity by using power of the engine; - a hydraulic pump operated by using the power of the engine and/or the motor generator; and - a controller configured to estimate engine power requirement (Pe) that is power required of the engine when a request to generate electricity is sent to the motor generator, and permit the motor generator to generate electricity only when the engine power requirement is equal to or less than a preset threshold value (E th1, E th), characterized in that the threshold value is set so that a rate of an increase in energy loss when the power of the engine increases by a predetermined value in a range smaller than the threshold value is smaller than a rate of an increase in energy loss when the power of the engine increases by the predetermined value in a range exceeding the threshold value. - an engine; - a motor generator for generating electricity by using power of the engine; - a hydraulic pump operated by using the power of the engine and/or the motor generator; and - a controller configured to estimate engine power requirement (Pe) that is power required of the engine when a request to generate electricity is sent to the motor generator, and permit the motor generator to generate electricity only when the engine power requirement is equal to or less than a preset threshold value (E th1, E th),
A polyethylene-2,6-naphthalate composition comprising a phosphorus compound represented by the following formula, cobalt element derived from a cobalt compound, manganese element derived from a manganese compound, and antimony element derived from an antimony compound, the content of each of the elements simultaneously satisfying the following expressions to: wherein R represents an alkyl group having 1 to 12 carbon atoms, an aryl group having 6 to 12 carbon atoms, or a benzyl group; 10 ≤ Co ≤ 30 mmol % 0.50 ≤ P / Mn ≤ 1.28 10 ≤ Sb ≤ 25 mmol % 0.60 ≤ IV ≤ 1.50 dL / g in the expressions to, Co, P, Mn, and Sb respectively represent the content of the cobalt element derived from the cobalt compound, the content of the phosphorus compound represented by the formula, the content of the manganese element derived from the manganese compound, and the content of the antimony element derived from the antimony compound, per mole of a dicarboxylic acid component constituting polyethylene-2,6-naphthalate in the polyethylene-2,6-naphthalate composition, and IV represents the intrinsic viscosity of the polyethylene-2,6-naphthalate composition; and wherein the element content of the polyethylene-2,6-naphthalate composition is measured by X-ray fluorescence.
A management method of an assistance system for a windscreen of a cab of a vehicle, the vehicle comprising a camera assembly including at least one camera having a field of vision between 150° and 180° and located on the top of the windscreen with an angle between 25° and 75° with respect to the windscreen, for providing a captured image of a wide angle field of view located in front of the vehicle, said wide angle field of view comprising a first front field of vision, a second field of vision of a class VI front-view according to the Regulation UN ECE n°46 and a third rear field of the vision, wherein the first front field of vision corresponds to a first part of the captured image, the second field of view corresponds to a second part of the captured image and the third field of view corresponds to a third part of the captured image, wherein the third rear field of vision provides the captured image including at least 60% of the windscreen, the method comprising: - Determining a state of the windscreen using the at least one camera, and - Processing the captured image, according to the state of the windscreen, to operate the windscreen system on the windscreen, wherein the processing of the captured image is based at least on the third part of the captured image. - Determining a state of the windscreen using the at least one camera, and - Processing the captured image, according to the state of the windscreen, to operate the windscreen system on the windscreen, wherein the processing of the captured image is based at least on the third part of the captured image.
Battery pack, characterised in that the battery pack comprises: a plurality of individual batteries; a battery holder for fixing the individual batteries; a circuit board electrically connected to the batteries and mounted on the battery holder; and a temperature sensor electrically connected to the circuit board and comprising a flexible sheet and a temperature sensing block attached to the flexible sheet, the temperature sensing block being thicker than the flexible sheet, wherein the battery holder is provided with a through mounting slot and is provided with a concave yielding slot on the side facing the batteries, the temperature sensor can pass through the mounting slot and be fixed by the battery holder and the batteries, and the temperature sensing block is accommodated in the yielding slot and in close contact with the batteries. a plurality of individual batteries; a battery holder for fixing the individual batteries; a circuit board electrically connected to the batteries and mounted on the battery holder; and a temperature sensor electrically connected to the circuit board and comprising a flexible sheet and a temperature sensing block attached to the flexible sheet, the temperature sensing block being thicker than the flexible sheet, wherein the battery holder is provided with a through mounting slot and is provided with a concave yielding slot on the side facing the batteries, the temperature sensor can pass through the mounting slot and be fixed by the battery holder and the batteries, and the temperature sensing block is accommodated in the yielding slot and in close contact with the batteries.
A pharmaceutical composition for use in treating an inflammatory skin disease or disorder, comprising an effective amount of 3-methanesulfonylpropionitrile, or a pharmaceutically acceptable salt or solvate thereof, wherein the inflammatory skin disease or disorder is acne or rosacea.
A compound represented by the general formula: wherein R 1 represents COOH, COOR 2, CH 2 OH, or CONR 3 R 4, R 2 represents a C1-C6 alkyl group optionally substituted with a hydroxy group, ONO 2 or a C1-4 alkoxy group, R 3 and R 4 each represent independently a hydrogen atom, or a C1-4 alkyl group optionally substituted with ONO 2, R 5 represents a halogen atom, a hydroxy group, or a C1-4 alkoxy group, Z represents -(CH 2) m -, -(CH 2) n -CH=CH-, -(CH 2) p -A-CH 2 -, or ring 1, A represents an oxygen atom, or a sulfur atom, W represents a C1-6 alkyl group optionally substituted with 1 to 5 substituents selected from the group consisting of a hydroxy group, an oxo group, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, ring 2, -O-ring 2, and - S-ring 2, ring 1 and ring 2 each represent independently a C3-10 carbocycle or a 3- to 10-membered heterocycle, optionally substituted with 1 to 5 substituents selected from the group consisting of a halogen atom, CF 3, OCF 3, a C1-4 alkoxy group, a C1-4 alkyl group, a hydroxy group, and a nitrile group, m represents an integer of 1 to 6, n represents an integer of 1 to 4, p represents an integer of 1 to 4, represents a single bond or a double bond, represents α configuration, represents β configuration, and represents α configuration, β configuration or an arbitrary mixture of them, or a salt thereof or a solvate thereof.
An ultrasonic emitter for ablation application comprising: (a) an active element having front and rear surfaces, said active element being operative to generate ultrasonic vibrations in response to an applied signal; (b) a rear structure (1714, 1720) defining a space disposed to the rear of said active element; and (c) a liquid in said space, wherein said space is open to an exterior of said active element, said active element, said rear structure and said liquid cooperatively forming a resonant unit, said resonant unit including a backing interface forming a reflective interface for acoustic energy, said liquid at least partially defining said backing interface, wherein said rear structure includes a wall having a front surface facing toward said space and a rear surface facing away from said space; and characterized in that the ultrasound emitter comprises d) an inner support; and the ultrasound emitter further comprises a gap formed between said rear structure and said inner support, wherein said gap comprises a medium having acoustic impedance lower than the acoustic impedance of said liquid, said medium abutting said rear surface of said wall. (a) an active element having front and rear surfaces, said active element being operative to generate ultrasonic vibrations in response to an applied signal; (b) a rear structure (1714, 1720) defining a space disposed to the rear of said active element; and (c) a liquid in said space, wherein said space is open to an exterior of said active element, d) an inner support; and the ultrasound emitter further comprises a gap formed between said rear structure and said inner support, wherein said gap comprises a medium having acoustic impedance lower than the acoustic impedance of said liquid, said medium abutting said rear surface of said wall.
A metalware, where the surface thereof is coated with a layer which is a hydrolysis and polycondensation product of a composition comprising tetraethoxy silane (TEOS), methyl trimethoxy silane (MTMS), dimethyl siloxane, inorganic filler and polar solvent characterized in that the said composition comprises 1,3-dialkyl imidazolium alkyl sulfate.
A rotorcraft provided on its top with a fairing longitudinally extended in the longitudinal orientation of extension of the rotorcraft which is defined between the front and the rear of the rotorcraft considered when on the ground, said fairing covering a mechanism enabling a pilot of the rotorcraft to operate the blades of a main rotor with a substantially vertical axis providing at least the lift for the rotorcraft, said fairing being formed below the rotary wing of the main rotor and above a cowling covering a power plant of the rotorcraft, the profile of the fairing considered in a horizontal plane of the rotorcraft being in the shape of a drop of water, characterised in that said profile is truncated with a rear end comprising transversely equally well a truncated portion and/or an inclined plane forming two lateral trailing edges (13, 13', 14, 14', 78, 78', 88, 88') of the fairing, each oriented transversely to said horizontal plane of the rotorcraft, each of said two lateral trailing edges (13, 13', 14, 14', 78, 78', 88, 88') of the fairing being provided with at least one mobile member (15, 65, 75, 85) having a degree of freedom in rotation relative to the fairing along said two trailing edges (13, 13', 14, 14', 78, 78', 88, 88'), said at least one mobile member (15, 65, 75, 85) guiding a first airflow flowing along the fairing and escaping from one of said two trailing edges (13, 13', 14, 14', 78, 78', 88, 88') towards the rear of the rotorcraft during flight.
Fire service lift with a lift cage having a cage roof, a first side wall and a second side wall, wherein the lift cage is at least partly supported and driven by at least one support means, characterised in that the lift cage is looped under by at least one support means so that the at least one support means runs along the two opposite side walls, wherein the fire service lift is designed so that the lift cage in an operational state reaches speeds of more than 1 metre per second and wherein the lift cage has at least one protective element which is arranged substantially above a side wall so that extinguishing water falling onto the cage roof in the case of fire is substantially prevented from wetting the at least one support means.
Middle hoop system for a vehicle joint which is arranged between a vehicle front part and a vehicle rear part of a vehicle and forms a passage between the vehicle front part and the vehicle rear part, comprising a cable strand, wherein the cable strand is designed to extend between the vehicle front part and the vehicle rear part, and a middle hoop, wherein the middle hoop is designed to surround the passage, and wherein the cable strand can be arranged above the passage, furthermore comprising a pivot lever between the middle hoop and the cable strand, wherein a first pivot joint is formed between the pivot lever and the middle hoop, characterized in that the pivot lever guides the cable strand at a radial distance from the axis of the first pivot joint.
A foamable, alcohol-based composition for disinfecting skin, which is free of silicone surfactants and free of polyfluorinated chemicals, containing: a) ethanol, n-propanol and/or i-propanol in an aqueous solution with an alcohol content of more than 50 wt% and b) one or more hydrogenated phospholipids in a proportion of 0.5-5 wt% in relation to the total amount of the liquid. a) ethanol, n-propanol and/or i-propanol in an aqueous solution with an alcohol content of more than 50 wt%
A method of detecting and quantifying a biomolecule target analyte in a sample, the method comprising: a) providing a sample and a substrate, said sample comprising a biomolecule target analyte, said substrate containing at least 1000 reaction vessels, each reaction vessel having a defined volume of between 10 attoliters and 50 picoliters; b) contacting the substrate with the sample so that reaction vessels contain biomolecule target analyte bound to capture components such that the ratio of biomolecule target analyte to the number of reaction vessels is less than 1:1; and c) determining the fraction of reaction vessels which contain a single biomolecule. a) providing a sample and a substrate, said sample comprising a biomolecule target analyte, said substrate containing at least 1000 reaction vessels, each reaction vessel having a defined volume of between 10 attoliters and 50 picoliters; b) contacting the substrate with the sample so that reaction vessels contain biomolecule target analyte bound to capture components such that the ratio of biomolecule target analyte to the number of reaction vessels is less than 1:1; and c) determining the fraction of reaction vessels which contain a single biomolecule.
Winding machine (100; 100a, 100b) for wrapping strands of rolled material, such as a bar, a rod, wire or the like, around a reel into coils, comprising: - a reel (50; 50a, 50b); - a base flange defining a first catching recess intended to receive an end of a first strand (17; 17a, 17b); - a first cover movable between an open position leaving said first catching recess exposed and a closed position wherein it covers said first catching recess to form a closed passage for the end of said first strand (17; 17a, 17b) in order to secure said end of said first strand to the reel (50; 50a, 50b); characterized in that said winding machine (100; 100a, 100b) further comprises: - at least a second element defining a second catching recess; and - at least a second cover movable between an open position leaving said further catching recess exposed and a closed position wherein it covers said second catching recess to form a closed passage for the end of a second strand (27; 27a, 27b) in order to secure said end of said second strand to the reel (50; 50a, 50b). - a reel (50; 50a, 50b); - a base flange defining a first catching recess intended to receive an end of a first strand (17; 17a, 17b); - a first cover movable between an open position leaving said first catching recess exposed and a closed position wherein it covers said first catching recess to form a closed passage for the end of said first strand (17; 17a, 17b) in order to secure said end of said first strand to the reel (50; 50a, 50b); characterized in that said winding machine (100; 100a, 100b) further comprises: - at least a second element defining a second catching recess; and - at least a second cover movable between an open position leaving said further catching recess exposed and a closed position wherein it covers said second catching recess to form a closed passage for the end of a second strand (27; 27a, 27b) in order to secure said end of said second strand to the reel (50; 50a, 50b). - at least a second element defining a second catching recess; and - at least a second cover movable between an open position leaving said further catching recess exposed and a closed position wherein it covers said second catching recess to form a closed passage for the end of a second strand (27; 27a, 27b) in order to secure said end of said second strand to the reel (50; 50a, 50b).
A positively-electrified charged niosome, comprising: a niosome which includes as a constituent thereof a lipid containing at least one or a plurality of diacylglycerol PEG adducts chosen from a group which consists of glycerol PEG dioleate-12, glycerol PEG dimyristate-12, glycerol PEG dipalmitate-23, glycerol PEG distearate-12 and glycerol PEG distearate-23, and encapsulates a specified aqueous solution; and a cationic surfactant modifying a surface of the niosome with a positive charge of the hydrophilic part of the cationic surfactant; such that the niosome is charged with a zeta potential within a range of 60mV to 80mV, wherein the cationic surfactant is one or a plurality of cationic surfactants chosen from a group which consists of an aliphatic amine, an aliphatic or aliphatic-amide quaternary ammonium salt,an aliphatic amideamine and an acylamino acid derivative, and the hydrophobic part of the cationic surfactant contains one saturated or unsaturated normal hydrocarbon group having a carbon number of 11 to 21. a niosome which includes as a constituent thereof a lipid containing at least one or a plurality of diacylglycerol PEG adducts chosen from a group which consists of glycerol PEG dioleate-12, glycerol PEG dimyristate-12, glycerol PEG dipalmitate-23, glycerol PEG distearate-12 and glycerol PEG distearate-23, and encapsulates a specified aqueous solution; and a cationic surfactant modifying a surface of the niosome with a positive charge of the hydrophilic part of the cationic surfactant; such that the niosome is charged with a zeta potential within a range of 60mV to 80mV, wherein the cationic surfactant is one or a plurality of cationic surfactants chosen from a group which consists of an aliphatic amine, an aliphatic or aliphatic-amide quaternary ammonium salt,an aliphatic amideamine and an acylamino acid derivative, and the hydrophobic part of the cationic surfactant contains one saturated or unsaturated normal hydrocarbon group having a carbon number of 11 to 21.
A disinfectant composition for hard articles used for disinfection of the surfaces of hard articles comprising: a two-agent type disinfectant composition including a first agent containing a powder mixture and a second agent containing an aqueous hydrogen peroxide solution (B-1), wherein the powder mixture containing an alkali metal salt (A-1) exhibiting basicity when the salt is in a form of an aqueous solution, a water-soluble copper salt (A-2), a compound (A-3) represented by the following formula, and a nonionic surfactant (A-4) represented by the following formula, wherein a molar ratio of the water-soluble copper salt (A-2) and the compound (A-3) represented by a mixing amount of (A-3)/mixing amount of (A-2) is 3.0 to 20: wherein Y 1 and Y 2 each independently represent a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, -CH 2 -COOX 3, -CH -COOX 4, -CH 2 CH 2 -COOX 5, -CH 2 CH 2 -OH or CH 2 -OH; Z represents a hydrogen atom, an alkyl group having 8 to 16 carbon atoms, -CH 2 -COOX 6 or CH 2 CH 2 -OH; X 1 to X 6 each independently represent a hydrogen atom, an alkali metal atom, an alkaline earth metal atom, or a cationic ammonium group; [Chemical Formula 2] R 1 O p q H wherein R 1 represents an alkyl group or alkenyl group having 8 to 20 carbon atoms; EO represents an oxyethylene group; PO represents an oxypropylene group; p represents the average number of added moles of EO and is a number of 2 to 10; q represents the average number of added moles of PO and is a number of 1 to 2; and p > q. a two-agent type disinfectant composition including a first agent containing a powder mixture and a second agent containing an aqueous hydrogen peroxide solution (B-1), wherein the powder mixture containing an alkali metal salt (A-1) exhibiting basicity when the salt is in a form of an aqueous solution, a water-soluble copper salt (A-2), a compound (A-3) represented by the following formula, and a nonionic surfactant (A-4) represented by the following formula, wherein a molar ratio of the water-soluble copper salt (A-2) and the compound (A-3) represented by a mixing amount of (A-3)/mixing amount of (A-2) is 3.0 to 20: wherein Y 1 and Y 2 each independently represent a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, -CH 2 -COOX 3, -CH -COOX 4, -CH 2 CH 2 -COOX 5, -CH 2 CH 2 -OH or CH 2 -OH; Z represents a hydrogen atom, an alkyl group having 8 to 16 carbon atoms, -CH 2 -COOX 6 or CH 2 CH 2 -OH; X 1 to X 6 each independently represent a hydrogen atom, an alkali metal atom, an alkaline earth metal atom, or a cationic ammonium group; [Chemical Formula 2] R 1 O p q H wherein R 1 represents an alkyl group or alkenyl group having 8 to 20 carbon atoms; EO represents an oxyethylene group; PO represents an oxypropylene group; p represents the average number of added moles of EO and is a number of 2 to 10; q represents the average number of added moles of PO and is a number of 1 to 2; and p > q.