Apparatus comprising: a device for delivery of a therapeutic fluid into a body of a patient and/or for sensing of a bodily analyte, the device having an opening configured as a well; and an insertion device comprising: a housing having accomodated therein: at least one penetrating cartridge comprising a penetrating member and a subcutaneously insertable element; and a manually actuable displacement mechanism which upon actuation is capable of protracting said penetrating cartridge towards the device for delivery and/or sensing, with protraction resulting in insertion of at least the subcutaneously insertable element (1100 into a subcutaneous compartment of the body; with said insertion device being suitable for inserting at least the subcutaneously insertable element into the subcutaneous compartment of the body via the opening provided in the device for delivery and/or sensing and said insertion device being suitable for allowing evacuation of the penetrating member from the subcutaneous compartment via said opening; characterized in that said insertion device further comprises a position enabling feature which is a safety mechanism for preventing the displacement mechanism from being actuated when said penetrating cartridge is not aligned with the well and which allows actuation of the displacement mechanism only when the insertion device has been placed in a predetermined position with respect to the device for delivery and/or sensing, said safety mechanism including indentation grooves on an upper surface of the device and matching positioning protrusions on a lower surface of the housing of the inserteion device, with correct positioning of the positioning protrusions inside the indentation grooves allowing movement of a safety rod to enable protracting of the penetrating cartridge when the penetrating cartridge is aligned with the well, with the safety rod being locked in a safety position preventing actuation of the displacement mechanism when the positioning protrusions are not properly located inside the indentation grooves. a device for delivery of a therapeutic fluid into a body of a patient and/or for sensing of a bodily analyte, the device having an opening configured as a well; and an insertion device comprising: a housing having accomodated therein: at least one penetrating cartridge comprising a penetrating member and a subcutaneously insertable element; and a manually actuable displacement mechanism which upon actuation is capable of protracting said penetrating cartridge towards the device for delivery and/or sensing, with protraction resulting in insertion of at least the subcutaneously insertable element (1100 into a subcutaneous a housing having accomodated therein: at least one penetrating cartridge comprising a penetrating member and a subcutaneously insertable element; and a manually actuable displacement mechanism which upon actuation is capable of protracting said penetrating cartridge towards the device for delivery and/or sensing, with protraction resulting in insertion of at least the subcutaneously insertable element (1100 into a subcutaneous compartment of the body; with said insertion device being suitable for inserting at least the subcutaneously insertable element into the subcutaneous compartment of the body via the opening provided in the device for delivery and/or sensing and said insertion device being suitable for allowing evacuation of the penetrating member from the subcutaneous compartment via said opening; characterized in that said insertion device further comprises a position enabling feature which is a safety mechanism for preventing the displacement mechanism from being actuated when said penetrating cartridge is not aligned with the well and which allows actuation of the displacement mechanism only when the insertion device has been placed in a predetermined position with respect to the device for delivery and/or sensing, said safety mechanism including indentation grooves on an upper surface of the device and matching positioning protrusions on a lower surface of the housing of the inserteion device, with correct positioning of the positioning protrusions inside the indentation grooves allowing movement of a safety rod to enable protracting of the penetrating cartridge when the penetrating cartridge is aligned with the well, with the safety rod being locked in a safety position preventing actuation of the displacement mechanism when the positioning protrusions are not properly located inside the indentation grooves.