A wellbore monitoring system comprising: a packing element configured to at least partially seal an uphole portion of a wellbore from a downhole portion of the wellbore, wherein the packing element includes a first hydraulic power unit (310, 312, 314, 501) operatively coupled to one or more processors of a control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors; a first annular pressure sensor configured to be positioned uphole of the packing element, the first annular pressure sensor configured to measure a first pressure within the wellbore uphole of the packing element; a second annular pressure sensor configured to be positioned downhole of the packing element, the second annular pressure sensor configured to measure a second pressure within the wellbore downhole of the packing element; the control sub-assembly configured to be positioned within the wellbore, the control sub-assembly configured to monitor a sealing efficiency of the system by comparing the first pressure and the second pressure, wherein the control sub-assembly includes a power source and the one or more processors, wherein the power source is operatively coupled to the one or more processors and configured to provide operating power to the one or more processors; a cylindrical body that supports the packing element, the first annular pressure sensor, the second annular pressure sensor, and the control sub-assembly; a first packer slip configured to be positioned nearer an uphole end of the cylindrical body than a downhole end of the cylindrical body, the first packer slip configured to at least partially support the system, wherein the first packer slip is operatively coupled to a second hydraulic power unit (310, 312, 314, 401) that is operatively coupled to the one or more processors of the control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors; and a second packer slip configured to be positioned nearer the downhole end of the cylindrical body than the uphole end of the cylindrical body, the second packer slip configured to at least partially support the system, wherein the second packer slip is operatively coupled to a third hydraulic power unit (310, 312, 314, 401) that is operatively coupled to the one or more processors of the control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors. a packing element configured to at least partially seal an uphole portion of a wellbore from a downhole portion of the wellbore, wherein the packing element includes a first hydraulic power unit (310, 312, 314, 501) operatively coupled to one or more processors of a control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors; a first annular pressure sensor configured to be positioned uphole of the packing element, the first annular pressure sensor configured to measure a first pressure within the wellbore uphole of the packing element; a second annular pressure sensor configured to be positioned downhole of the packing element, the second annular pressure sensor configured to measure a second pressure within the wellbore downhole of the packing element; the control sub-assembly configured to be positioned within the wellbore, the control sub-assembly configured to monitor a sealing efficiency of the system by comparing the first pressure and the second pressure, wherein the control sub-assembly includes a power source and the one or more processors, wherein the power source is operatively coupled to the one or more processors and configured to provide operating power to the one or more processors; a cylindrical body that supports the packing element, the first annular pressure sensor, the second annular pressure sensor, and the control sub-assembly; a first packer slip configured to be positioned nearer an uphole end of the cylindrical body than a downhole end of the cylindrical body, the first packer slip configured to at least partially support the system, wherein the first packer slip is operatively coupled to a second hydraulic power unit (310, 312, 314, 401) that is operatively coupled to the one or more processors of the control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors; and a second packer slip configured to be positioned nearer the downhole end of the cylindrical body than the uphole end of the cylindrical body, the second packer slip configured to at least partially support the system, wherein the second packer slip is operatively coupled to a third hydraulic power unit (310, 312, 314, 401) that is operatively coupled to the one or more processors of the control sub-assembly to receive at least a portion of a set of sealing instructions from the one or more processors.