An instrument for delivering a transfascial suture, the instrument comprising: a handle; a drive mechanism housed in the handle; an elongated shaft (406, 1104) extending from the handle, the elongated shaft including a distal end; a first drive member (414,1112) and a second drive member (414,1112), the first and second drive members (414,1112) being operatively coupled to the drive mechanism and moveable along respective drive paths from a retracted position not extending beyond the distal end of the elongated shaft (406,1104) to an extended position beyond the distal end of the elongated shaft (406,1104) in response to actuation of the drive mechanism; a suture carried by the instrument, the suture defined by a first suture segment (452,1122) and a second suture segment (452,1124); and a first suture retainer (450,500,600,750,1004,1120,1208) connected to the first suture segment (452,1122) and located in a first drive path, and a second suture retainer (450,500,600,750,1004,1120,1208) connected to the second suture segment (452,1124) and located in a second drive path, the first and second suture retainers (450,500,600,750 1004,1120,1208) each having an axial bore and being carried by the instrument to be driven from the elongated shaft (406,1104) along the respective first and second drive paths by the first and second drive members (414,1112) as the first and second drive members (414,1112) are moved to the extended position, the bore of each of the first and second suture retainers (450,500,600,750,1004,1120,1208) being configured to receive respective first and second drive members (414,1112) to drive said first and second suture retainers (450,500,600,750,1004,1120,1208) from the elongated shaft (406, 1104). a handle; a drive mechanism housed in the handle; an elongated shaft (406, 1104) extending from the handle, the elongated shaft including a distal end; a first drive member (414,1112) and a second drive member (414,1112), the first and second drive members (414,1112) being operatively coupled to the drive mechanism and moveable along respective drive paths from a retracted position not extending beyond the distal end of the elongated shaft (406,1104) to an extended position beyond the distal end of the elongated shaft (406,1104) in response to actuation of the drive mechanism; a suture carried by the instrument, the suture defined by a first suture segment (452,1122) and a second suture segment (452,1124); and a first suture retainer (450,500,600,750,1004,1120,1208) connected to the first suture segment (452,1122) and located in a first drive path, and a second suture retainer (450,500,600,750,1004,1120,1208) connected to the second suture segment (452,1124) and located in a second drive path, the first and second suture retainers (450,500,600,750 1004,1120,1208) each having an axial bore and being carried by the instrument to be driven from the elongated shaft (406,1104) along the respective first and second drive paths by the first and second drive members (414,1112) as the first and second drive members (414,1112) are moved to the extended position, the bore of each of the first and second suture retainers (450,500,600,750,1004,1120,1208) being configured to receive respective first and second drive members (414,1112) to drive said first and second suture retainers (450,500,600,750,1004,1120,1208) from the elongated shaft (406, 1104).