A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl; R 2, R 3, R 4, R 5, are independently hydrogen or halogen; R 6, R 7, R 8 and R 10 are independently hydrogen, cyano or halogen; R 9 is hydrogen or optionally substituted C 1 -C 6 alkyl; and R 11 is -COR 12, -CONR 12 R 13, or -SO 2 NR 12 R 13, where R 12 is optionally substituted aryl or optionally substituted heteroaryl; and R 13 is hydrogen or optionally substituted alkyl; wherein each optionally substituted group is unsubstituted or independently substituted with one or more substituents independently selected from the group consisting of C 1 -C 4 alkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl, -OC 1 -C 4 alkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -cosh, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 alkylphenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); provided that when R 10 is fluoro, then R 7 is not hydrogen, or R 8 is not hydrogen, or R 6 is not hydrogen, or halo. R 1 is hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl; R 2, R 3, R 4, R 5, are independently hydrogen or halogen; R 6, R 7, R 8 and R 10 are independently hydrogen, cyano or halogen; R 9 is hydrogen or optionally substituted C 1 -C 6 alkyl; and R 11 is -COR 12, -CONR 12 R 13, or -SO 2 NR 12 R 13, where R 12 is optionally substituted aryl or optionally substituted heteroaryl; and R 13 is hydrogen or optionally substituted alkyl; wherein each optionally substituted group is unsubstituted or independently substituted with one or more substituents independently selected from the group consisting of C 1 -C 4 alkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl, -OC 1 -C 4 alkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -cosh, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 alkylphenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); provided that when R 10 is fluoro, then R 7 is not hydrogen, or R 8 is not hydrogen, or R 6 is not hydrogen, or halo.