A method for quantification and characterization of one or more types of viruses or viral particles, comprising the steps of: a) treating specimens comprising said viruses or viral particles with one or more enzymes to obtain a plurality of viral samples, wherein said specimens are treated in a solvent before or after treating with said one or more enzymes; b) applying a first viral sample to a size exclusion chromatographic system comprising a plurality of pumps and a plurality of size exclusion chromatographic columns, wherein i. a first pump is connected to a first size exclusion chromatographic column via a first valve, said first column is further connected via a second valve to a detection system comprising a Dynamic Light Scattering detector and an UV detector; and ii. a second pump is connected to a second size exclusion chromatographic column via said first valve, said second column is further connected via said second valve to a waste collector, wherein the first viral sample is run through the first column while a washing buffer is run through the second column; c) eluting the first viral sample from the first column and obtaining chromatographic profile for quantification and characterization of the first viral sample by said detection system; d) switching connections for said first and second pumps so that i. said first pump is now connected to said second column via said first valve, said second column is further connected via said second valve to said detection system; and ii. said second pump is now connected to said first column via said first valve, said first column is further connected via said second valve to a waste collector; e) applying a second viral sample to the second column while applying a washing buffer to the first column; f) eluting said second viral sample from said second column and obtaining chromatographic profile for quantification and characterization of said second viral sample by said detection system; and g) repeating the steps of (b) to (f), thereby obtaining quantification and characterization of said plurality of viral samples. a) treating specimens comprising said viruses or viral particles with one or more enzymes to obtain a plurality of viral samples, wherein said specimens are treated in a solvent before or after treating with said one or more enzymes; b) applying a first viral sample to a size exclusion chromatographic system comprising a plurality of pumps and a plurality of size exclusion chromatographic columns, wherein i. a first pump is connected to a first size exclusion chromatographic column via a first valve, said first column is further connected via a second valve to a detection system comprising a Dynamic Light Scattering detector and an UV detector; and ii. a second pump is connected to a second size exclusion chromatographic column via said first valve, said second column is further connected via said second valve to a waste collector, wherein the first viral sample is run through the first column while a washing buffer is run through the second column; i. a first pump is connected to a first size exclusion chromatographic column via a first valve, said first column is further connected via a second valve to a detection system comprising a Dynamic Light Scattering detector and an UV detector; and ii. a second pump is connected to a second size exclusion chromatographic column via said first valve, said second column is further connected via said second valve to a waste collector, c) eluting the first viral sample from the first column and obtaining chromatographic profile for quantification and characterization of the first viral sample by said detection system; d) switching connections for said first and second pumps so that i. said first pump is now connected to said second column via said first valve, said second column is further connected via said second valve to said detection system; and ii. said second pump is now connected to said first column via said first valve, said first column is further connected via said second valve to a waste collector; i. said first pump is now connected to said second column via said first valve, said second column is further connected via said second valve to said detection system; and ii. said second pump is now connected to said first column via said first valve, said first column is further connected via said second valve to a waste collector; e) applying a second viral sample to the second column while applying a washing buffer to the first column; f) eluting said second viral sample from said second column and obtaining chromatographic profile for quantification and characterization of said second viral sample by said detection system; and g) repeating the steps of (b) to (f), thereby obtaining quantification and characterization of said plurality of viral samples.