mhurhangee/ep-ind-claims huggingface dataset:
A process for drying a protein solution comprising: a) Selecting a target pH for the dried protein, which target pH is between 6.0 and 8.5 b) Selecting a target pH for the protein solution, which target pH between 7.4 and 11.0 c) Providing an aqueous phase, d) Adding a protein, e) Optionally adding excipients, f) Adjusting the pH with a non volatile base and optionally a non volatile acid to the target pH for the dried protein, which base has a vapour pressure below 65 Pa at room temperature and which acid has a vapour pressure below 65 Pa at room temperature, g) Adjusting the pH with a volatile base to the target pH of the protein solution to be dried, which bases which have a vapour pressure above 65 Pa at room temperature or which bases is an aqueous azeotropic mixture including a base having a vapour pressure above 65 Pa at room temperature and h) Spray-drying, spray freeze drying or freeze drying the protein solution. wherein the steps d, e, f and g can be carried out in any order while stirring continuously, wherein the protein is selected from the group consisting of insulin, insulin analogues, insulin derivatives, GLP-1, GLP-1 analogues and GLP-1 derivatives, glucagon and/or any combination thereof. a) Selecting a target pH for the dried protein, which target pH is between 6.0 and 8.5 b) Selecting a target pH for the protein solution, which target pH between 7.4 and 11.0 c) Providing an aqueous phase, d) Adding a protein, e) Optionally adding excipients, f) Adjusting the pH with a non volatile base and optionally a non volatile acid to the target pH for the dried protein, which base has a vapour pressure below 65 Pa at room temperature and which acid has a vapour pressure below 65 Pa at room temperature, g) Adjusting the pH with a volatile base to the target pH of the protein solution to be dried, which bases which have a vapour pressure above 65 Pa at room temperature or which bases is an aqueous azeotropic mixture including a base having a vapour pressure above 65 Pa at room temperature and h) Spray-drying, spray freeze drying or freeze drying the protein solution. wherein the steps d, e, f and g can be carried out in any order while stirring continuously, wherein the protein is selected from the group consisting of insulin, insulin analogues, insulin derivatives, GLP-1, GLP-1 analogues and GLP-1 derivatives, glucagon and/or any combination thereof.
Apparatus for sealing an opening (O/A-F/3a-3h/4a-4d/5d-5j/206a-c) to a compartment defined by at least one edge, including: a seal layer (10/30/102) sized and configured to cover said opening (O/A-F/3a-3h/4a-4d/5d-5j/206a-c), said seal layer (10/30/102) to effectively adhere to at least substantially all of the edge of said opening, at least one additional layer (104/106) of material provided in a generally parallel and confronting overlying relationship with and on top of said seal layer (10/30/102), said apparatus is characterised by said seal layer (10/30/102) having a plurality of tear lines (12/14/L/TL) defining a plurality of portions (5a-c/22/24/26) of the seal layer (10/30/102) to be positioned over the opening (O/A-F/3a-3h/4a-4d/5d-5j/206a-c) of the compartment, the tear lines (12/14/L/TL) positioned and formed for selective tearing to permit selective removal of at least two of the plurality of portions (5a-c/22/24/26) of the seal layer (10/30/102) from the opening (O/A-F/3a-3h/4a-4d/Sd-Sj/206a-c), and said additional material (104/106) being separable along a line in a location of the additional material (104/106) that does not have a tear line, said line at least generally corresponding to one of the plurality of tear lines (12/14/L/TL) of the seal layer (10/30/102) when said one of the plurality of tear lines (12/14/L/TL) is selectively torn. a seal layer (10/30/102) sized and configured to cover said opening (O/A-F/3a-3h/4a-4d/5d-5j/206a-c), said seal layer (10/30/102) to effectively adhere to at least substantially all of the edge of said opening, at least one additional layer (104/106) of material provided in a generally parallel and confronting overlying relationship with and on top of said seal layer (10/30/102), said apparatus is characterised by said seal layer (10/30/102) having a plurality of tear lines (12/14/L/TL) defining a plurality of portions (5a-c/22/24/26) of the seal layer (10/30/102) to be positioned over the opening (O/A-F/3a-3h/4a-4d/5d-5j/206a-c) of the compartment, the tear lines (12/14/L/TL) positioned and formed for selective tearing to permit selective removal of at least two of the plurality of portions (5a-c/22/24/26) of the seal layer (10/30/102) from the opening (O/A-F/3a-3h/4a-4d/Sd-Sj/206a-c), and said additional material (104/106) being separable along a line in a location of the additional material (104/106) that does not have a tear line, said line at least generally corresponding to one of the plurality of tear lines (12/14/L/TL) of the seal layer (10/30/102) when said one of the plurality of tear lines (12/14/L/TL) is selectively torn.
A multiphase detergent or cleaning composition comprising at least one liquid phase containing from 1 to 20% by weight of water, the term liquid including all flowable phases, in particular also gels and pasty compositions, and at least one solid, powder or granular phase, characterized in that the at least one solid, powder or granular phase contains at least one particle comprising at least one bleach activator, the at least one bleach activator being compounded with at least one complexing agent.
An in vitro method for assessing the disease burden in human neuroblastoma patients comprising: - providing a sample obtained from a patient, - quantifying the expression level of all of the following miRNAs: miR-124-3p, miR-375, miR-323a-3p, miR-129-5p, miR-218-5p, miR-490-5p, miR-149-5p, miR-873-3p and miR-10b-3p in said sample, and, - assessing the disease burden based on the quantity of the expression level of all of said miRNAs wherein a relative increased abundance of all of said miRNAs correlates with an increased disease burden, wherein said assessing the disease burden allows to monitor disease and to evaluate treatment response. - providing a sample obtained from a patient, - quantifying the expression level of all of the following miRNAs: miR-124-3p, miR-375, miR-323a-3p, miR-129-5p, miR-218-5p, miR-490-5p, miR-149-5p, miR-873-3p and miR-10b-3p in said sample, and, - assessing the disease burden based on the quantity of the expression level of all of said miRNAs wherein a relative increased abundance of all of said miRNAs correlates with an increased disease burden, wherein said assessing the disease burden allows to monitor disease and to evaluate treatment response.
Method for determining the position of an object point in a scene from a digital image of said scene acquired through a 3-D camera having an optical system, said image comprising a number of image points corresponding to respective object points, wherein distance information is also associated with each image point, which is indicative of the measured remoteness of the corresponding object point, characterized in that a stored, respective predetermined vector is associated with each of said image points, each predetermined vector being determined by calibration and representing the direction of a light ray in the object space that will produce the associated image point through said optical system, said predetermined vector including the optical distortion through the optical system; and in that the three dimensional coordinates of object points are determined by means of the predetermined vector and the distance information associated with the respective image points.
An aircraft fuel tank comprising: a tank wall enclosing a liquid storage space, the tank wall comprising two opposing aircraft external skins and an aircraft substructure disposed between the two aircraft external skins; and a plurality of tie assemblies located at least partially within the liquid storage space, each tie assembly comprising: a first attachment device fixed to an inner surface of a first of the aircraft external skins; a second attachment device fixed to an inner surface of a second of the aircraft external skins; and an elongate member fixed between the first and second attachment devices of that tie assembly such that the elongate member of that tie assembly crosses the liquid storage space; and the tie assemblies are more closely spaced together at or proximate to points at which the aircraft external skins are attached to the aircraft substructure. a tank wall enclosing a liquid storage space, the tank wall comprising two opposing aircraft external skins and an aircraft substructure disposed between the two aircraft external skins; and a plurality of tie assemblies located at least partially within the liquid storage space, each tie assembly comprising: a first attachment device fixed to an inner surface of a first of the aircraft external skins; a second attachment device fixed to an inner surface of a second of the aircraft external skins; and an elongate member fixed between the first and second attachment devices of that tie assembly such that the elongate member of that tie assembly crosses the liquid storage space; and a first attachment device fixed to an inner surface of a first of the aircraft external skins; a second attachment device fixed to an inner surface of a second of the aircraft external skins; and an elongate member fixed between the first and second attachment devices of that tie assembly such that the elongate member of that tie assembly crosses the liquid storage space; and the tie assemblies are more closely spaced together at or proximate to points at which the aircraft external skins are attached to the aircraft substructure.
A vehicle service system for a vehicle including a set of wheels, the vehicle service system having a central processor (106, 206), and an output device operatively connected to the central processor (106, 206), characterised in that: the central processor (106, 206) is further configured to utilize at least one lateral force measurement associated with each vehicle wheel to identify a placement location for each vehicle wheel that minimizes the sum of the lateral forces acting upon the vehicle's axles, and to provide to an operator through said output device the placement location for each said vehicle wheel about the vehicle to minimize a net lateral force acting upon the vehicle during vehicle travel.
An Internet Protocol, IP, camera control method, comprising: receiving, by an IP camera, a standby instruction sent by a server; switching, by the IP camera, from a working state to a standby state, powering off a security chip and an image sensor of the IP camera, and keeping a Wi-Fi module in the IP camera running when receiving the standby instruction from the server; constructing, by the IP camera, a heartbeat packet to be transmitted between the IP camera and the server; sending, by the IP camera, the heartbeat packet to the server at a first preset frequency to make the IP camera maintain a heartbeat connection to the server when in the standby state; receiving, by the IP camera, a wake-up instruction from the server by using the Wi-Fi module; and switching, by the IP camera, from the standby state to the working state and powering on the security chip and the image sensor of the IP camera when receiving the wake-up instruction from the server. receiving, by an IP camera, a standby instruction sent by a server; switching, by the IP camera, from a working state to a standby state, powering off a security chip and an image sensor of the IP camera, and keeping a Wi-Fi module in the IP camera running when receiving the standby instruction from the server; constructing, by the IP camera, a heartbeat packet to be transmitted between the IP camera and the server; sending, by the IP camera, the heartbeat packet to the server at a first preset frequency to make the IP camera maintain a heartbeat connection to the server when in the standby state; receiving, by the IP camera, a wake-up instruction from the server by using the Wi-Fi module; and switching, by the IP camera, from the standby state to the working state and powering on the security chip and the image sensor of the IP camera when receiving the wake-up instruction from the server.
A beach umbrella made of two separate parts, a pole, to be fitted to the ground, and the upper part including the canopy, wherein the pole comprises a serrated element with side fins on the lower end of the beach umbrella, and wherein the element also comprises a central hole, that allows sand to flow without any friction, characterized in that the pole comprises a lever with a rotary knob hinged on the upper part of the pole, enabling its rotation.
Vessel lower part for a metallurgical vessel, having a vessel wall, a vessel base, a melt space and at least one tapping device for drawing off liquid metal (4a, 4b) from the melt space, wherein the melt space is designed to receive > 100 t of liquid metal (4a, 4b) and there is at least one first tapping device designed as a siphon, which device has at least two separate inlet openings (6a, 6b) in the vessel wall for the purpose of transferring the liquid metal from the melt space into the first tapping device, wherein the inlet openings (6a, 6b) open into a single supply channel and the supply channel opens, in the region of at least one overflow edge, into a single discharge channel, or wherein each inlet opening (6a, 6b) opens into a separate supply channel (7a, 7b) and the supply channels (7a, 7b) open, in the region of at least one overflow edge (8a, 8b), into a single discharge channel.
Injector, having a control valve for opening a connection between a control chamber for controlling a nozzle needle position and a prechamber of a fluid return line, wherein a pressure compensation means is arranged in the prechamber for compensating a change in a prechamber pressure, wherein the pressure compensation means has at least one body which is sealed off with respect to the prechamber and in which there is arranged a compressible medium (301, 407) characterized in that an actuator is provided for actuating the control valve and in that the body is formed as a double-walled diaphragm which seals off the actuator with respect to the prechamber.
A needle channel usable in a hair transplanter, the needle channel being configured to be coupled to an outer circumference of a center shaft in the hair transplanter to be slidable up and down, the needle channel comprising: a body having a tubular inner space formed therein; a needle coupled to a lower end of the body; a core shaft slidably disposed in the tubular inner space and the needle; characterized in that a slot formed on the body in a longitudinal direction and opened in an outward radial direction from a center axis of the center shaft; a lever coupled to an upper end of the core shaft, and disposed to be slidable up and down in the slot; and a spring fitted over a circumference of the core shaft and having an upper end supported on the lever and a lower end supported on a bottom surface of the slot. a body having a tubular inner space formed therein; a needle coupled to a lower end of the body; a core shaft slidably disposed in the tubular inner space and the needle; characterized in that a slot formed on the body in a longitudinal direction and opened in an outward radial direction from a center axis of the center shaft; a lever coupled to an upper end of the core shaft, and disposed to be slidable up and down in the slot; and a spring fitted over a circumference of the core shaft and having an upper end supported on the lever and a lower end supported on a bottom surface of the slot.
Sealing arrangement, comprising at least one abradable seal for sealing off a gap between a rotor and a housing, wherein the abradable seal has a sealing shell with an oval opening for receiving the rotor and wherein the rotor is supported by active magnetic bearings, and provision is made of touchdown bearings, which perform the mounting of the rotor in the event of failure or during downtime of the rotor, characterized in that the abradable seal is arranged in such a manner that the longitudinal axis thereof is oriented in a substantially vertical manner, wherein the longitudinal axis corresponds substantially to the direction of the main axis of the rotor deflection.
A power cable comprising: a. a plurality of cores, surrounded by an outer covering, the area between any two adjacent cores and the immediately opposing inner surface of the outer covering defining an interstitial zone, b. a plurality of elongated plastic fillers, said fillers having a central, interstices-filling portion arranged to essentially fill an interstitial zone, and two curved, outwardly extending arm portions, c. at least a part of the arm portions is arranged intermediate the cores and the outer covering, forming a barrier between the cores and the inner surface of the outer covering, characterized in that the number of cores as well as the number of fillers is three, and wherein the arm portions of adjacent fillers abutting to form the barrier between the cores and the outer covering. a. a plurality of cores, surrounded by an outer covering, the area between any two adjacent cores and the immediately opposing inner surface of the outer covering defining an interstitial zone, b. a plurality of elongated plastic fillers, said fillers having a central, interstices-filling portion arranged to essentially fill an interstitial zone, and two curved, outwardly extending arm portions, c. at least a part of the arm portions is arranged intermediate the cores and the outer covering, forming a barrier between the cores and the inner surface of the outer covering,
An ultraviolet radiation absorbing polymer composition comprising the reaction product of a monoglyceride and a poly-acid monomer containing a UV-chromophore.
Machine for treating objects, in particular for cleaning and disinfecting, characterized in that it comprises a frame, a treatment chamber provided with an aperture and a closing device for closing said aperture, said closing device comprising a flap door configured to rotate with respect to a corresponding hinging axis (Ah), a transmission member and a drive mean, wherein said transmission member comprises: - a first crank, provided with one end associated with the drive mean, and with an opposite end cooperating with - a second crank provided with one end associated with a rotation pintle, which defines the hinging axis (Ah) on which said door rotates, and an opposite free end associated with the first crank - a transmission strut which advantageously achieves the association between the first crank and the second crank, said closing device being configured so that the rotation of the first crank at least partly moves the second crank, about its axis of rotation, in a counter-clockwise direction or in a clockwise direction wherein said counter-clockwise direction and said clockwise direction coincide respectively with a corresponding opening rotation and closing rotation of the door, wherein the movement and the movement of the second crank, which have opposite directions to each other, are obtained with a rotation of the first crank which has a single direction. - a first crank, provided with one end associated with the drive mean, and with an opposite end cooperating with - a second crank provided with one end associated with a rotation pintle, which defines the hinging axis (Ah) on which said door rotates, and an opposite free end associated with the first crank - a transmission strut which advantageously achieves the association between the first crank and the second crank,
A method of producing a metal comprising: adding a catholyte comprising a quantity of metal alkoxide (M x), wherein M is a metal selected from the group consisting of Cerium, Aluminum, Tantalum, Titanium, Yttrium and Neodymium and x is the number that provides the stoichiometric balance of the M cation, dissolved in a solvent to a cathode compartment of an electrolytic cell, wherein the solvent is selected from ionic liquids, alcohols, polyols, and organic solvents and wherein the cathode compartment includes a cathode; adding an anolyte comprising alkali metal ions to an anode compartment of the electrolytic cell, wherein the anode compartment includes an anode; separating the cathode compartment from the anode compartment with an alkali-ion selective membrane that allows alkali metal ions to migrate from the anode compartment to the cathode compartment; and electrolyzing the electrolytic cell to cause alkali metal ions to migrate from the anode compartment into the cathode compartment and react with the metal alkoxide (M x) thereby producing the metal, and an alkali metal alkoxide. adding a catholyte comprising a quantity of metal alkoxide (M x), wherein M is a metal selected from the group consisting of Cerium, Aluminum, Tantalum, Titanium, Yttrium and Neodymium and x is the number that provides the stoichiometric balance of the M cation, dissolved in a solvent to a cathode compartment of an electrolytic cell, wherein the solvent is selected from ionic liquids, alcohols, polyols, and organic solvents and wherein the cathode compartment includes a cathode; adding an anolyte comprising alkali metal ions to an anode compartment of the electrolytic cell, wherein the anode compartment includes an anode; separating the cathode compartment from the anode compartment with an alkali-ion selective membrane that allows alkali metal ions to migrate from the anode compartment to the cathode compartment; and electrolyzing the electrolytic cell to cause alkali metal ions to migrate from the anode compartment into the cathode compartment and react with the metal alkoxide (M x) thereby producing the metal, and an alkali metal alkoxide.
An OLED display, comprising: a. a substrate formed of a flexible material; b. an OLED having two spaced-apart electrodes (20, 40) and organic layers disposed there between, and the OLED formed on the substrate; and c. an encapsulation container fixed by a perimeter seal to the substrate and disposed over the OLED to provide an enclosure; characterized in that the substrate includes compliant regions that flex, compress, or expand under stress and reduce stress transfer between the substrate or the encapsulation container through the perimeter seal, wherein the compliant regions are provided by spaced-apart bends or flexures in the substrate. a. a substrate formed of a flexible material; b. an OLED having two spaced-apart electrodes (20, 40) and organic layers disposed there between, and the OLED formed on the substrate; and c. an encapsulation container fixed by a perimeter seal to the substrate and disposed over the OLED to provide an enclosure;