A method of determining an overall toxicity in a consumable product, comprising: a) combining a polar organic solvent and the consumable product to obtain a polar organic extract with an overall toxicity; b) contacting a teleost embryo with the organic extract of a); and c) determining whether the extract exerts a toxicity effect on the embryo; wherein a toxicity effect on the embryo shows an overall toxicity of the consumable product; wherein the consumable product is a lipid-containing consumable product, and the polar organic extract of step a) is further delipidated with a non-polar solvent; wherein if the sample is a low lipid containing sample it is not delipidated with a non-polar solvent; wherein the polar organic solvent is acetonitrile, ethanol, propanol, isopropanol, or a mixture containing two or more solvents thereof; wherein the teleost is fish of the Oryzias genus, the Danio genus or the Pimephales genus; and wherein the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the volume of the sample, when the sample is a liquid; or the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the weight of the sample, when the sample is a solid or semi-solid. a) combining a polar organic solvent and the consumable product to obtain a polar organic extract with an overall toxicity; b) contacting a teleost embryo with the organic extract of a); and c) determining whether the extract exerts a toxicity effect on the embryo; wherein a toxicity effect on the embryo shows an overall toxicity of the consumable product; wherein the consumable product is a lipid-containing consumable product, and the polar organic extract of step a) is further delipidated with a non-polar solvent; wherein if the sample is a low lipid containing sample it is not delipidated with a non-polar solvent; wherein the polar organic solvent is acetonitrile, ethanol, propanol, isopropanol, or a mixture containing two or more solvents thereof; wherein the teleost is fish of the Oryzias genus, the Danio genus or the Pimephales genus; and wherein the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the volume of the sample, when the sample is a liquid; or the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the weight of the sample, when the sample is a solid or semi-solid. wherein a toxicity effect on the embryo shows an overall toxicity of the consumable product; wherein the consumable product is a lipid-containing consumable product, and the polar organic extract of step a) is further delipidated with a non-polar solvent; wherein if the sample is a low lipid containing sample it is not delipidated with a non-polar solvent; wherein the polar organic solvent is acetonitrile, ethanol, propanol, isopropanol, or a mixture containing two or more solvents thereof; wherein the teleost is fish of the Oryzias genus, the Danio genus or the Pimephales genus; and wherein the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the volume of the sample, when the sample is a liquid; or the volume of the polar organic solvent combined with the consumable sample to form a mixture is 1 to 5 times the weight of the sample, when the sample is a solid or semi-solid.