A compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is -C NH- or -NHC -; R 1 is (C 1 -C 4)alkyl -C(=O)OR c, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, - NR d R e, monocyclic heterocyclyl, or monocyclic cycloalkyl, wherein said (C 1 -C 4)alkyl is optionally substituted with -OR c, said monocyclic heterocyclyl is optionally substituted with (C 1 -C 4)alkyl or =O, and said monocyclic cycloalkyl is optionally substituted with -C(=O)OR c, -CN, or one or more halo; L 2 is CH 2, CHMe, or cyclopropyl; Cy 1 is aryl, heteroaryl, heterocyclyl, or cycloalkyl, each of which is optionally substituted with 1 to 3 groups independently selected from R 5; Cy 2 is bicyclic heterocyclyl or bicyclic heteroaryl, each of which is optionally substituted with 1 to 3 groups independently selected from R 6; R 5 and R 6 are each independently selected from halo, -CN, -OR c, -NR d R e, -S k R b, - NR c S 2 R c, -S 2 NR d R e, -C(=O)OR c, -OC(=O)OR c, -OC(=O)R c, -OC(=S)OR c, -C(=S)OR c, - OC(=S)R c, -C(=O)NR d R e, -NR c C(=O)R c, -C(=S)NR d R e, -NR c C(=S)R c, -NR c C(=O)OR c, - OC(=O)NR d R e, -NR c (C=S)OR c, -OC(=S)NR d R e, -NR c C(=O)NR d R e, -NR c (C=S)NR d R e, - C(=S)R c, -C(=O)R c, oxo, (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -NHC(=O)-heterocyclyl, -NHC(=O)-cycloalkyl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl portion present in each of said (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl substituent for R 5 and R 6 are further optionally substituted with one or more halo, OR c, -NO 2, -CN, -NR c C(=O)R c, -NR d R e, -S k R b, -C(=O)OR c, -C(=O)NR d R e, -C(=O)R c, (C 1 -C 3)alkyl, halo(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy, or halo(C 1 -C 3)alkoxy; R 7 and R 8 are each independently hydrogen, OR c, -C(=O)OR c, monocyclic heterocyclyl, halophenyl, or (C 1 -C 3)alkyl, wherein the (C 1 -C 3)alkyl is optionally substituted with OR c, -NR d R e, -O(C 1 -C 3)alkyl-C(=O)OR c, -C(=O)OR c, -C(=O)NR d R e, or halophenyl; k is 0, 1 or 2; each R b is independently selected from hydrogen and (C 1 -C 3)alkyl optionally substituted with OH, -O(C 1 -C 3)alkyl, -C O(C 1 -C 3)alkyl, -C NH 2, -C NH(C 1 -C 3)alkyl, or - C N((C 1 -C 3)alkyl) 2; each R c is independently selected from hydrogen and (C 1 -C 3)alkyl optionally substituted with one or more halo; and each R d and R e is independently selected from hydrogen and (C 1 -C 3)alkyl. X is -C NH- or -NHC -; R 1 is (C 1 -C 4)alkyl -C(=O)OR c, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, - NR d R e, monocyclic heterocyclyl, or monocyclic cycloalkyl, wherein said (C 1 -C 4)alkyl is optionally substituted with -OR c, said monocyclic heterocyclyl is optionally substituted with (C 1 -C 4)alkyl or =O, and said monocyclic cycloalkyl is optionally substituted with -C(=O)OR c, -CN, or one or more halo; L 2 is CH 2, CHMe, or cyclopropyl; Cy 1 is aryl, heteroaryl, heterocyclyl, or cycloalkyl, each of which is optionally substituted with 1 to 3 groups independently selected from R 5; Cy 2 is bicyclic heterocyclyl or bicyclic heteroaryl, each of which is optionally substituted with 1 to 3 groups independently selected from R 6; R 5 and R 6 are each independently selected from halo, -CN, -OR c, -NR d R e, -S k R b, - NR c S 2 R c, -S 2 NR d R e, -C(=O)OR c, -OC(=O)OR c, -OC(=O)R c, -OC(=S)OR c, -C(=S)OR c, - OC(=S)R c, -C(=O)NR d R e, -NR c C(=O)R c, -C(=S)NR d R e, -NR c C(=S)R c, -NR c C(=O)OR c, - OC(=O)NR d R e, -NR c (C=S)OR c, -OC(=S)NR d R e, -NR c C(=O)NR d R e, -NR c (C=S)NR d R e, - C(=S)R c, -C(=O)R c, oxo, (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -NHC(=O)-heterocyclyl, -NHC(=O)-cycloalkyl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl portion present in each of said (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl substituent for R 5 and R 6 are further optionally substituted with one or more halo, OR c, -NO 2, -CN, -NR c C(=O)R c, -NR d R e, -S k R b, -C(=O)OR c, -C(=O)NR d R e, -C(=O)R c, (C 1 -C 3)alkyl, halo(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy, or halo(C 1 -C 3)alkoxy; R 7 and R 8 are each independently hydrogen, OR c, -C(=O)OR c, monocyclic heterocyclyl, halophenyl, or (C 1 -C 3)alkyl, wherein the (C 1 -C 3)alkyl is optionally substituted with OR c, -NR d R e, -O(C 1 -C 3)alkyl-C(=O)OR c, -C(=O)OR c, -C(=O)NR d R e, or halophenyl; k is 0, 1 or 2; each R b is independently selected from hydrogen and (C 1 -C 3)alkyl optionally substituted with OH, -O(C 1 -C 3)alkyl, -C O(C 1 -C 3)alkyl, -C NH 2, -C NH(C 1 -C 3)alkyl, or - C N((C 1 -C 3)alkyl) 2; each R c is independently selected from hydrogen and (C 1 -C 3)alkyl optionally substituted with one or more halo; and each R d and R e is independently selected from hydrogen and (C 1 -C 3)alkyl.