A replacement mitral valve configured to be deployed within a native mitral valve, the replacement mitral valve comprising: an expandable frame (20, 20', 20", 20"') comprising a proximal portion (38, 38', 38"') configured to be positioned in a left atrium, a distal portion (42, 42', 42"') and a transition portion (40, 40', 40"') between the proximal and distal portions, wherein a diameter of the distal portion is greater than a diameter of the proximal portion, and wherein the frame is configured to radially expand and collapse for deployment within the native mitral valve; a valve body (30, 30"') attached to the expandable frame, the valve body comprising a proximal end, a distal end, and a plurality of valve leaflets (32, 32', 32"'), wherein the plurality of valve leaflets are configured to open to allow flow in a first direction from the proximal end to the distal end and are configured to engage one another to close and not allow flow in a direction opposite the first direction; a plurality of proximal anchors (22, 22', 22", 22"') each connected to the frame so that when the frame is in its expanded configuration an end of each proximal anchor is positioned radially outward from the frame; wherein the proximal anchors are configured to be positioned on an atrial side of a native mitral valve annulus; and a plurality of distal anchors (24, 24', 24", 24"') each connected to the frame so that when the frame is in its expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends proximally and substantially parallel to a longitudinal axis of the frame, wherein the distal anchors extend from the distal portion of the frame and are configured to be positioned on a ventricular side of the native mitral valve annulus. an expandable frame (20, 20', 20", 20"') comprising a proximal portion (38, 38', 38"') configured to be positioned in a left atrium, a distal portion (42, 42', 42"') and a transition portion (40, 40', 40"') between the proximal and distal portions, wherein a diameter of the distal portion is greater than a diameter of the proximal portion, and wherein the frame is configured to radially expand and collapse for deployment within the native mitral valve; a valve body (30, 30"') attached to the expandable frame, the valve body comprising a proximal end, a distal end, and a plurality of valve leaflets (32, 32', 32"'), wherein the plurality of valve leaflets are configured to open to allow flow in a first direction from the proximal end to the distal end and are configured to engage one another to close and not allow flow in a direction opposite the first direction; a plurality of proximal anchors (22, 22', 22", 22"') each connected to the frame so that when the frame is in its expanded configuration an end of each proximal anchor is positioned radially outward from the frame; wherein the proximal anchors are configured to be positioned on an atrial side of a native mitral valve annulus; and a plurality of distal anchors (24, 24', 24", 24"') each connected to the frame so that when the frame is in its expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends proximally and substantially parallel to a longitudinal axis of the frame, wherein the distal anchors extend from the distal portion of the frame and are configured to be positioned on a ventricular side of the native mitral valve annulus.