A method for co-producing HFO-1234ze and HFC-245fa, characterized in that the method comprises the following steps: adding into a first reactor a starting material stream that contains anhydrous HF and HCC-240fa, and in the presence of oxygen and the action of a fluorination catalyst, reacting the anhydrous HF and HCC-240fa to produce a product stream; adding the product stream into a first separation tower to form a material stream that contains HCL at the top of the first separation tower and a material stream that contains HFC-245fa, HCFC-1233zd and HF in a boiler of the first separation tower; introducing the material stream into a second reactor and simultaneously introducing into the second reactor oxygen to react, under the action of a fluorination catalyst, and form a product stream; introducing the product stream into a second separation tower to form a material stream containing HCL and trans-HFO-1234ze at the top of the second separation tower, and a material stream containing cis-HFO-1234ze, HFC-245fa, HCFC-1233zd, HCFC-244fa and HF in the boiler of the second separation tower, wherein the material stream, after washing with water, separation, and drying, produces trans-HFO-1234ze; introducing the material stream into a static can; after layer separation, circulating the upper layer, material stream comprising primarily HF, back into the first reactor, wherein the lower layer organic phase forming material stream that comprises cis-HFO-1234ze, HFC-245fa and HCFC-1233zd; introducing the material stream into a third separation tower, wherein a material stream forms at the top of the third separation tower and contains primarily cis-HFO-1234ze, and a material stream formed in the boiler of the third separation tower comprises HFC-245fa and HCFC-1233zd, wherein the material stream is isomerized to produce trans-HFO-1234ze; introducing the material stream into a fourth separation tower, wherein a material stream formed at the top of the fourth separation tower comprises HFC-245fa, and a material stream formed in the boiler of the fourth separation tower comprise HCFC-1233zd, wherein the material stream is circulated back into the first separation tower or the second reactor. adding into a first reactor a starting material stream that contains anhydrous HF and HCC-240fa, and in the presence of oxygen and the action of a fluorination catalyst, reacting the anhydrous HF and HCC-240fa to produce a product stream; adding the product stream into a first separation tower to form a material stream that contains HCL at the top of the first separation tower and a material stream that contains HFC-245fa, HCFC-1233zd and HF in a boiler of the first separation tower; introducing the material stream into a second reactor and simultaneously introducing into the second reactor oxygen to react, under the action of a fluorination catalyst, and form a product stream; introducing the product stream into a second separation tower to form a material stream containing HCL and trans-HFO-1234ze at the top of the second separation tower, and a material stream containing cis-HFO-1234ze, HFC-245fa, HCFC-1233zd, HCFC-244fa and HF in the boiler of the second separation tower, wherein the material stream, after washing with water, separation, and drying, produces trans-HFO-1234ze; introducing the material stream into a static can; after layer separation, circulating the upper layer, material stream comprising primarily HF, back into the first reactor, wherein the lower layer organic phase forming material stream that comprises cis-HFO-1234ze, HFC-245fa and HCFC-1233zd; introducing the material stream into a third separation tower, wherein a material stream forms at the top of the third separation tower and contains primarily cis-HFO-1234ze, and a material stream formed in the boiler of the third separation tower comprises HFC-245fa and HCFC-1233zd, wherein the material stream is isomerized to produce trans-HFO-1234ze; introducing the material stream into a fourth separation tower, wherein a material stream formed at the top of the fourth separation tower comprises HFC-245fa, and a material stream formed in the boiler of the fourth separation tower comprise HCFC-1233zd, wherein the material stream is circulated back into the first separation tower or the second reactor.