mhurhangee/ep-ind-claims huggingface dataset:
A compound 15 to 30 nucleobases in length targeted to a nucleic acid molecule encoding human glucagon receptor for use in treating high blood glucose, treating diabetes, treating obesity or treating insulin resistance, wherein said compound specifically hybridizes with said nucleic acid molecule encoding human glucagon receptor and inhibits the expression of human glucagon receptor, and wherein the compound comprises: a) a phosphorothioate backbone; b) at least one modified sugar moiety, which is a 2'-O-methoxyethyl sugar moiety or a bicyclic sugar moiety in which a methylene (-CH 2 -) n group bridges the 2' oxygen atom and the 4' carbon atom of the sugar ring and wherein n is 1 or 2; and/or c) at least one modified nucleobase, and wherein the compound has at least 90% complementarity with a nucleic acid molecule of SEQ ID NO: 4 encoding human glucagon receptor. a) a phosphorothioate backbone; b) at least one modified sugar moiety, which is a 2'-O-methoxyethyl sugar moiety or a bicyclic sugar moiety in which a methylene (-CH 2 -) n group bridges the 2' oxygen atom and the 4' carbon atom of the sugar ring and wherein n is 1 or 2; and/or c) at least one modified nucleobase,
Device for delivering a product to the base of hair shafts and/or on the scalp of a predefined user, characterised in that it comprises: - a base comprising a container for the product, equipped with a filler cap, and an electric pump aspirating the product in the container and pushing it into a flexible tube, and - a case connected to the flexible tube, a case whose geometry is configured to be held in the palm of the user's hand and comprising a row of assemblies having a convex distal surface of contact with the user's head, these assemblies comprising a tooth, at least one nozzle and at least one applicator, this tooth being configured to separate the hair strands down to their roots, each nozzle being configured to deliver the product onto the roots of the hair strands separated by the tooth and/or on the scalp between the hair strands separated by the tooth, and each applicator being configured to spread the product delivered by at least one nozzle over the roots and/or scalp, all the convex distal surfaces of the assemblies being tangential to a flat curve whose radius of curvature is equal to a radius of curvature of the user's skull, this case also comprising a control button for controlling the operation of the pump. - a base comprising a container for the product, equipped with a filler cap, and an electric pump aspirating the product in the container and pushing it into a flexible tube, and - a case connected to the flexible tube, a case whose geometry is configured to be held in the palm of the user's hand and comprising a row of assemblies having a convex distal surface of contact with the user's head, these assemblies comprising a tooth, at least one nozzle and at least one applicator, this tooth being configured to separate the hair strands down to their roots, each nozzle being configured to deliver the product onto the roots of the hair strands separated by the tooth and/or on the scalp between the hair strands separated by the tooth, and each applicator being configured to spread the product delivered by at least one nozzle over the roots and/or scalp, all the convex distal surfaces of the assemblies being tangential to a flat curve whose radius of curvature is equal to a radius of curvature of the user's skull, this case also comprising a control button for controlling the operation of the pump.
A multi-blade rotor for a rotary wing aircraft, comprising an associated rotor head and a plurality of rotor blades (2a, 2b, 2c, 2d, 2e) connected to the associated rotor head via a plurality of flexbeam elements (10a, 10b, 10c, 10d, 10e), wherein at least one flexbeam element (10a, 10b, 10c, 10d, 10e) of the plurality of flexbeam elements (10a, 10b, 10c, 10d, 10e) comprises an asymmetrical flexbeam root (14a, 14b, 14c, 14d, 14e) that is mounted to the associated rotor head; characterized in that the asymmetrical flexbeam root (14a, 14b, 14c, 14d, 14e) is in an associated longitudinal flexbeam direction approximately L- or shoe-shaped and comprises a single-sided longitudinal extension (13a, 13b, 13c) oriented at least approximately towards the associated rotor head.
An isolated FcRn-antagonist which consists of a variant IgG1 Fc region, or FcRn-binding fragment thereof, wherein the Fc domains of the Fc region or FcRn-binding fragment thereof comprise the amino acids Y, T, E, K, F, and Y at EU positions 252, 254, 256, 433, 434, and 436 respectively, and wherein the Fc region binds to FcRn with increased affinity and reduced pH dependence relative to a wild-type IgG1 Fc region.
A sanitary cleaning device comprising: a nozzle configured to discharge water toward a region of a user; a water supply path through which water is supplied to the nozzle; a backflow prevention mechanism including a tank provided on the water supply path, a water inlet port that is communicated with an upstream water supply path positioned upstream of the tank on the water supply path and through which water flows into the tank, a water outlet port that is communicated with a downstream water supply path positioned downstream of the tank on the water supply path and through which water in the tank flows out to the downstream water supply path, and an overflow port that is provided to form an air gap between the overflow port and the water inlet port and through which surplus water in the tank is discharged; a solution provision unit configured to supply acid solution provided by the user to the tank; and a control unit configured to execute scale removal processing of filling the downstream water supply path and the nozzle with the acid solution accumulated in the tank and then discharging the acid solution from the downstream water supply path and the nozzle, wherein, when having received the instruction to transition to the scale removal mode, the control unit executes water discharge processing of discharging water in the tank before the scale removal processing. a nozzle configured to discharge water toward a region of a user; a water supply path through which water is supplied to the nozzle; a backflow prevention mechanism including a tank provided on the water supply path, a water inlet port that is communicated with an upstream water supply path positioned upstream of the tank on the water supply path and through which water flows into the tank, a water outlet port that is communicated with a downstream water supply path positioned downstream of the tank on the water supply path and through which water in the tank flows out to the downstream water supply path, and an overflow port that is provided to form an air gap between the overflow port and the water inlet port and through which surplus water in the tank is discharged; a solution provision unit configured to supply acid solution provided by the user to the tank; and a control unit configured to execute scale removal processing of filling the downstream water supply path and the nozzle with the acid solution accumulated in the tank and then discharging the acid solution from the downstream water supply path and the nozzle, wherein, when having received the instruction to transition to the scale removal mode, the control unit executes water discharge processing of discharging water in the tank before the scale removal processing.
A combined flue ozone distribution system, comprising a first ozone distributor and a second ozone distributor that are disposed in a flue, wherein the first ozone distributor and the second ozone distributor each comprises: a plurality of main distribution pipes, a plurality of branch distribution pipes, and connecting pipes configured to supply ozone, wherein both sides of each of the plurality of main distribution pipes are each provided with a branch distribution pipe, a first end of one of the plurality of main distribution pipes is communicated with a connecting pipe, and a second end of the one of the plurality of main distribution pipes is communicated with a branch distribution pipe, characterized in that the first ozone distributor further comprises hemispherical distributors, and one of the hemispherical distributors is disposed at an end of the one of the plurality of branch distribution pipes of the first ozone distributor; the second ozone distributor further comprises rhombic guide plates, and one of the rhombic guide plates is disposed at an end of the one of the plurality of branch distribution pipes of the second ozone distributor. a plurality of main distribution pipes, a plurality of branch distribution pipes, and connecting pipes configured to supply ozone, wherein both sides of each of the plurality of main distribution pipes are each provided with a branch distribution pipe, a first end of one of the plurality of main distribution pipes is communicated with a connecting pipe, and a second end of the one of the plurality of main distribution pipes is communicated with a branch distribution pipe, characterized in that the first ozone distributor further comprises hemispherical distributors, and one of the hemispherical distributors is disposed at an end of the one of the plurality of branch distribution pipes of the first ozone distributor; the second ozone distributor further comprises rhombic guide plates, and one of the rhombic guide plates is disposed at an end of the one of the plurality of branch distribution pipes of the second ozone distributor.
A method for determining the amount of insulin in a biological sample by tandem mass spectrometry, the method comprising: (a) subjecting the sample to conditions suitable to generate insulin B chains from insulin; (b) processing the sample from step (a) to obtain a fraction enriched in insulin B chains; (c) subjecting the enriched insulin B chains to an ionization source under conditions suitable to generate one or more insulin B chain ions detectable by mass spectrometry, wherein said one or more ions comprise a precursor ion with a mass to charge ratio (m/z) of 1144.2 ± 0.5, 686.8 ± 0.5, 1181.9 ± 0.5, 886.9 ± 0.5, or 709.8 ± 0.5 wherein 1181.9 ± 0.5, 886.9 ± 0.5 and 709.8 ± 0.5 are m/z of alkylated insulin B chains and (d) determining the amount of one or more insulin B chain ions by tandem mass spectrometry, wherein the amount of ions determined in step (d) is related to the amount of insulin in said sample. (a) subjecting the sample to conditions suitable to generate insulin B chains from insulin; (b) processing the sample from step (a) to obtain a fraction enriched in insulin B chains; (c) subjecting the enriched insulin B chains to an ionization source under conditions suitable to generate one or more insulin B chain ions detectable by mass spectrometry, wherein said one or more ions comprise a precursor ion with a mass to charge ratio (m/z) of 1144.2 ± 0.5, 686.8 ± 0.5, 1181.9 ± 0.5, 886.9 ± 0.5, or 709.8 ± 0.5 wherein 1181.9 ± 0.5, 886.9 ± 0.5 and 709.8 ± 0.5 are m/z of alkylated insulin B chains and (d) determining the amount of one or more insulin B chain ions by tandem mass spectrometry,
An apparatus for binding stacks of flat parts comprising - a fixing unit for fixing a stack consisting of a plurality of flat parts, - a binder application device for applying liquid binder along a narrow face of the stack, - an irradiating unit for curing the binder by irradiating the binder on the narrow face of the stack, characterised in that a light-emitting diode unit being used for irradiation. - a fixing unit for fixing a stack consisting of a plurality of flat parts, - a binder application device for applying liquid binder along a narrow face of the stack, - an irradiating unit for curing the binder by irradiating the binder on the narrow face of the stack, characterised in that a light-emitting diode unit being used for irradiation.
Photonic chip comprising a substrate and a light guiding layer, the light guiding layer being supported by the substrate and including a light guiding structure optically coupled with a surface coupling array, the photonic chip having a front face on the side of the surface coupling array, a rear face on the side of the substrate and including a collimation structure integrated at the level of the rear face to increase the mode size of a light beam incident on said structure from the surface coupling array and to collimate this beam, the surface coupling array being configured to receive/transfer light from/to the light guiding structure and form/receive a light towards/from the collimation structure integrated at the level of the rear face, characterised in that the collimation structure is a reflective structure suitable for reflecting said incident light beam towards the front face and to perform extraction from said front face of a collimated light beam.
A hinged shield assembly comprising: a needle hub including a flange and a first hinge part formed with the flange, a needle extending from the needle hub and comprising a lengthwise axis; a shield including a second hinge part that engages the first hinge part to pivotably secure the shield to the hub, the shield further including a plurality of sidewalls (110, 112, 114) that partially surround the needle when the shield is in a protected position; wherein each of the sidewalls (110, 112, 114) comprises a base end; characterized in that the hinged shield assembly further comprises at least one stop piece extending radially of the lengthwise axis from the flange of the needle hub and located in a rotational path of the shield such that at least one of the plurality of sidewalls (110, 112, 114) contacts the at least one stop piece to prevent over rotation of the base end of each of the sidewalls (110, 112, 114) beyond an at rest point upon contact with the at least one stop piece in one rotational direction when the shield is in the protected position, and wherein the at least one stop piece includes a flat distal side configured to contact a proximal edge or contact edge of the at least one of the plurality of sidewalls (110, 112, 114) of the shield. a needle hub including a flange and a first hinge part formed with the flange, a needle extending from the needle hub and comprising a lengthwise axis; a shield including a second hinge part that engages the first hinge part to pivotably secure the shield to the hub, the shield further including a plurality of sidewalls (110, 112, 114) that partially surround the needle when the shield is in a protected position; wherein each of the sidewalls (110, 112, 114) comprises a base end; characterized in that the hinged shield assembly further comprises at least one stop piece extending radially of the lengthwise axis from the flange of the needle hub and located in a rotational path of the shield such that at least one of the plurality of sidewalls (110, 112, 114) contacts the at least one stop piece to prevent over rotation of the base end of each of the sidewalls (110, 112, 114) beyond an at rest point upon contact with the at least one stop piece in one rotational direction when the shield is in the protected position, and wherein the at least one stop piece includes a flat distal side configured to contact a proximal edge or contact edge of the at least one of the plurality of sidewalls (110, 112, 114) of the shield.
A rotor blade arrangement of a compressor or turbine stage of a gas turbine, comprising a plurality of rotor blades, a balancing body, and a ring, wherein the ring is either a radially outer ring that is formed of outer shrouds of the rotor blades of the rotor blade arrangement, or is a radially inner ring (4, 5) that is formed of blade platforms of the rotor blades of the rotor blade arrangement, characterized in that the ring comprises a first axial shoulder (6; 7), and the balancing body comprises a first stop with which it is attached in a form-fitting manner in one peripheral direction to the first axial shoulder (6; 7) of the ring.
Connecting device for connecting a protective glove to a protective suit, particularly to a diving suit, having a securing ring for connecting a first protective suit-sided connecting body and a second glove-sided connecting body, characterised in that the securing ring comprises an equipment carrier for attaching equipment.
A method of automatically configuring a playback device (102-124; 200-204; 400; 602-606; 764, 774; 902) in a playback network (128; 961), the method comprising: receiving, by a controller device, a configuration table from a server over a wide area network, determining, by the controller device (130; 300; 500; 608; 762, 772; 930), that the configuration table: includes an entry corresponding to the playback device that is unconfigured for playback; and indicates that the playback device is a component of a bonded zone, wherein the bonded zone includes two or more playback devices configured to render a same or different channels of an audio signal in synchrony; receiving, by the controller device, a first message from the playback device indicating that the playback device is available to be configured; responsively, transmitting from the controller device to the playback device, a second message comprising setup information for the playback device corresponding to the received configuration table; and causing the playback device to be configured according to the received setup information. receiving, by a controller device, a configuration table from a server over a wide area network, determining, by the controller device (130; 300; 500; 608; 762, 772; 930), that the configuration table: includes an entry corresponding to the playback device that is unconfigured for playback; and indicates that the playback device is a component of a bonded zone, includes an entry corresponding to the playback device that is unconfigured for playback; and indicates that the playback device is a component of a bonded zone, wherein the bonded zone includes two or more playback devices configured to render a same or different channels of an audio signal in synchrony; receiving, by the controller device, a first message from the playback device indicating that the playback device is available to be configured; responsively, transmitting from the controller device to the playback device, a second message comprising setup information for the playback device corresponding to the received configuration table; and causing the playback device to be configured according to the received setup information.
A drilling apparatus comprising: • a hydraulically powered hammer comprising: ∘ a piston to impact a drill bit; ∘ a shuttle valve to control reciprocation of the piston; and ∘ an accumulator for hydraulic fluid; and ∘ a hammer connection valve for connection of the hammer to a drill rod; • at least one drill rod (3, 4) comprising: ∘ a first connection valve for connection of the drill rod (3, 4) to the hammer; and ∘ a second connection valve for connection of the drill rod (3, 4) to the first connection valve of a like drill rod (3, 4) or to a rotation device wherein • the piston and shuttle valve are positioned substantially in-line to the axis of movement of the hammer; • the accumulator is positioned proximate to the shuttle valve; and each of the hammer connection valve, first connection valve and second connection valve comprises at least one poppet (19, 23) positioned proximate to a corresponding valve seat (20, 26), characterized in that each of the hammer connection valve and second connection valve comprises an inner connection valve seal and an outer connection valve seal which are configured to minimise hydraulic fluid loss from a pressure oil flow path and return oil flow path respectively during operation of the apparatus and connection and disconnection of each drill rod (3, 4). • a hydraulically powered hammer comprising: ∘ a piston to impact a drill bit; ∘ a shuttle valve to control reciprocation of the piston; and ∘ an accumulator for hydraulic fluid; and ∘ a hammer connection valve for connection of the hammer to a drill rod; ∘ a piston to impact a drill bit; ∘ a shuttle valve to control reciprocation of the piston; and ∘ an accumulator for hydraulic fluid; and ∘ a hammer connection valve for connection of the hammer to a drill rod; • at least one drill rod (3, 4) comprising: ∘ a first connection valve for connection of the drill rod (3, 4) to the hammer; and ∘ a second connection valve for connection of the drill rod (3, 4) to the first connection valve of a like drill rod (3, 4) or to a rotation device ∘ a first connection valve for connection of the drill rod (3, 4) to the hammer; and ∘ a second connection valve for connection of the drill rod (3, 4) to the first connection valve of a like drill rod (3, 4) or to a rotation device • the piston and shuttle valve are positioned substantially in-line to the axis of movement of the hammer; • the accumulator is positioned proximate to the shuttle valve; and each of the hammer connection valve, first connection valve and second connection valve comprises at least one poppet (19, 23) positioned proximate to a corresponding valve seat (20, 26), characterized in that each of the hammer connection valve and second connection valve comprises an inner connection valve seal and an outer connection valve seal which are configured to minimise hydraulic fluid loss from a pressure oil flow path and return oil flow path respectively during operation of the apparatus and connection and disconnection of each drill rod (3, 4).
A method of manufacturing a packaging material for use in forming a package to enclose one or more items, the method comprising: a. laminating together at least two layers of materials to form a laminated packaging material having an inner laminate structure and an outer laminate structure, the inner laminate structure being translucent or transparent and the outer laminate structure being opaque; b. forming a score line in the opaque laminate structure to define a section within the outer opaque laminate structure which can be wholly or partially removed; characterized in that the method comprises forming the score line so that it only partially encircles the section such that the section remains attached to the remainder of the opaque laminate structure along a line about which the section of opaque laminate structure can be folded. a. laminating together at least two layers of materials to form a laminated packaging material having an inner laminate structure and an outer laminate structure, the inner laminate structure being translucent or transparent and the outer laminate structure being opaque; b. forming a score line in the opaque laminate structure to define a section within the outer opaque laminate structure which can be wholly or partially removed;