Method for enriching or depleting at least one hydrogen isotope in a gas stream, comprising the steps: a) providing of a gas stream which comprises, as gaseous components, at least two different hydrogen isotopes or at least one of the hydrogen isotopes and an inert gas; and b) providing of a moved solid which comprises at least one sorbent, wherein the sorbent is selected in such a manner that the gaseous components of the gas stream differ from each other in terms of an extent of absorption on the sorbent; characterized by c) alternately contacting of the moved solid and the gas stream i) at at least one first temperature at which absorption of the gaseous components of the gas stream on the sorbent occurs in at least one first region, and ii) at at least two second temperatures which differ from the first temperature and also from one another and at which desorption of one of the hydrogen isotopes among the gaseous components of the gas stream from the sorbent occurs in each case in at least one second region, wherein the at least one first region is maintained at the first temperature and the at least one second region is maintained at the two second temperatures differing from each other; until a desired degree of enrichment or depletion of at least one of the hydrogen isotopes is attained. a) providing of a gas stream which comprises, as gaseous components, at least two different hydrogen isotopes or at least one of the hydrogen isotopes and an inert gas; and b) providing of a moved solid which comprises at least one sorbent, wherein the sorbent is selected in such a manner that the gaseous components of the gas stream differ from each other in terms of an extent of absorption on the sorbent; characterized by c) alternately contacting of the moved solid and the gas stream i) at at least one first temperature at which absorption of the gaseous components of the gas stream on the sorbent occurs in at least one first region, and ii) at at least two second temperatures which differ from the first temperature and also from one another and at which desorption of one of the hydrogen isotopes among the gaseous components of the gas stream from the sorbent occurs in each case in at least one second region, wherein the at least one first region is maintained at the first temperature and the at least one second region is maintained at the two second temperatures differing from each other; until a desired degree of enrichment or depletion of at least one of the hydrogen isotopes is attained. i) at at least one first temperature at which absorption of the gaseous components of the gas stream on the sorbent occurs in at least one first region, and ii) at at least two second temperatures which differ from the first temperature and also from one another and at which desorption of one of the hydrogen isotopes among the gaseous components of the gas stream from the sorbent occurs in each case in at least one second region, wherein the at least one first region is maintained at the first temperature and the at least one second region is maintained at the two second temperatures differing from each other; until a desired degree of enrichment or depletion of at least one of the hydrogen isotopes is attained.