A compound of Formula II: or a pharmaceutically acceptable salt thereof, for use in treatment of heart failure, cardiac hypertrophy, myocarditis, myocardial infarction, ischemia, cardiac arrhythmias, vascular rhexis, valvulopathy, diastolic dysfunction, hypertension, cancer, neurodegenerative disorders, viral infection, liver disease, or inflammation in a patient in need thereof; wherein: Ar is aryl or heteroaryl, each of which is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected R 1a groups; W is S or O; Y is O; each X is N; Z is O, S, or NR A; R A is H or C 1-4 alkyl; R 1, R 2, R 3, and R 4 are each independently selected from hydrogen, halo, CN, nitro, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, di-C 1-4 -alkylamino, carboxy, carbamyl, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di-C 1-4 alkylaminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, and di-C 1-4 alkylaminosulfonylamino; wherein said C 1-6 alkyl, C 1-8 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, di-C 1-4 -alkylamino, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, and C 1-6 alkylcarbonyl are each optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino, and di-C 1-3- alkylamino; and each R 1A is independently selected from halo, CN, nitro, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 2-6 heterocycloalkyl, phenyl, C 1-6 heteroaryl, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, di-C 1-4 -alkylamino, carboxy, carbamyl, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylsulfonyl, C 1-8 alkylcarbonylamino, C 1-8 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di-C 1-4 alkylaminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, and di-C 1-4 alkylaminosulfonylamino; wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 2-6 heterocycloalkyl, phenyl, C 1-6 heteroaryl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, di-C 1-4 -alkylamino, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, and C 1-6 alkylcarbonyl are each optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino, and di-C 1-3 -alkylamino; or two adjacent R 1a taken together with the atoms to which they are attached can form a 3-7 membered carbocyclic or 4-6 membered heterocyclic ring, each of which is optionally substituted with 1, 2, 3, or 4 C 1-3 alkyl groups. Ar is aryl or heteroaryl, each of which is optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected R 1a groups; W is S or O; Y is O; each X is N; Z is O, S, or NR A; R A is H or C 1-4 alkyl; R 1, R 2, R 3, and R 4 are each independently selected from hydrogen, halo, CN, nitro, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, di-C 1-4 -alkylamino, carboxy, carbamyl, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di-C 1-4 alkylaminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, and di-C 1-4 alkylaminosulfonylamino; wherein said C 1-6 alkyl, C 1-8 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, di-C 1-4 -alkylamino, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, and C 1-6 alkylcarbonyl are each optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino, and di-C 1-3- alkylamino; and each R 1A is independently selected from halo, CN, nitro, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 2-6 heterocycloalkyl, phenyl, C 1-6 heteroaryl, C 1-6 alkoxy, C 1-6 haloalkoxy, amino, C 1-6 alkylamino, di-C 1-4 -alkylamino, carboxy, carbamyl, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylcarbonyloxy, C 1-6 alkylsulfonyl, C 1-8 alkylcarbonylamino, C 1-8 alkylsulfonylamino, aminosulfonyl, C 1-6 alkylaminosulfonyl, di-C 1-4 alkylaminosulfonyl, aminosulfonylamino, C 1-6 alkylaminosulfonylamino, and di-C 1-4 alkylaminosulfonylamino; wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 2-6 heterocycloalkyl, phenyl, C 1-6 heteroaryl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkylamino, di-C 1-4 -alkylamino, C 1-6 alkylcarbamyl, di(C 1-4 alkyl)carbamyl, and C 1-6 alkylcarbonyl are each optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino, and di-C 1-3 -alkylamino; or two adjacent R 1a taken together with the atoms to which they are attached can form a 3-7 membered carbocyclic or 4-6 membered heterocyclic ring, each of which is optionally substituted with 1, 2, 3, or 4 C 1-3 alkyl groups.