mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition formulated for subcutaneous injection comprising an anti-C5 antibody comprising the VH sequence of SEQ ID NO: 2 and the VL sequence of SEQ ID NO: 6 for use in a method of treatment or prevention of a C5-related disease selected from the group consisting of rheumatoid arthritis; lupus nephritis; ischemia-reperfusion injury; paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome (aHUS), dense deposit disease; macular degeneration; hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome; thrombotic thrombocytopenic purpura; spontaneous fetal loss; Pauci-immune vasculitis; epidermolysis bullosa; recurrent fetal loss; multiple sclerosis; traumatic brain injury; injury resulting from myocardial infarction, cardiopulmonary bypass or hemodialysis; refractory generalized myasthenia gravis (gMG), and neuromyelitis optica, wherein the composition is subcutaneously administered in two phases after a pharmaceutical composition formulated for intravenous injection comprising an anti-C5 antibody is administered, wherein in both phases of the subcutaneous administrations there is an interval between every two subcutaneous administrations, wherein each phase comprises at least one interval, wherein the antibody dose of the intravenous administration is 1,000 mg, wherein the first subcutaneous administration of the first phase is administered 0 to 8 days after the final administration of the intravenously administered pharmaceutical composition, wherein the dose of the antibody in the subcutaneous administration of the first phase is 170 mg or 340 mg, wherein the pharmaceutical composition is administered in the first phase once every week (weekly), and wherein the pharmaceutical composition for subcutaneous administration is administered in the second phase four-weekly at a dose of 680 mg. wherein the composition is subcutaneously administered in two phases after a pharmaceutical composition formulated for intravenous injection comprising an anti-C5 antibody is administered, wherein in both phases of the subcutaneous administrations there is an interval between every two subcutaneous administrations, wherein each phase comprises at least one interval, wherein the antibody dose of the intravenous administration is 1,000 mg, wherein the first subcutaneous administration of the first phase is administered 0 to 8 days after the final administration of the intravenously administered pharmaceutical composition, wherein the dose of the antibody in the subcutaneous administration of the first phase is 170 mg or 340 mg, wherein the pharmaceutical composition is administered in the first phase once every week (weekly), and wherein the pharmaceutical composition for subcutaneous administration is administered in the second phase four-weekly at a dose of 680 mg.
Espagnolette lock in particular for a double-leaf door with a bolt device, with a bolt of the bolt device that is extractable from a lock box, and with an espagnolette connecting slide of the bolt device that is shiftable diagonally to the movement of the bolt, with a guide curve arranged in the espagnolette connecting slide and with a guide element of the bolt that is coupled with the guide curve, wherein in a locking position of the bolt device the guide element is arranged in a guide portion of the guide curve arranged in the movement direction of the espagnolette connecting slide, with a protrusion of the bolt device movable between the locking position and a release position, arranged on the espagnolette connecting slide, wherein the protrusion supports the bolt in the locking position on a shoulder and is pushed out in the release position from the movement area of the shoulder, and with a control ramp arranged in the bolt to move out the protrusion from the movement area of the shoulder, characterised in that the espagnolette connecting slide has a support, that the support supports the bolt located in the locking position in relation to an abutment of the lock box and is moved out of the movement area of the bolt in the release position.
A pyrazolopyrimidine compound having a structure represented by formula, or a pharmaceutically acceptable salt thereof, or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate thereof, wherein, in the formula, R 1, R 2, R 3 and R 4 are each independently selected from H, halogen, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogen; R 5 is selected from H, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogens, C 1-12 alkyl substituted by hydroxy, C 2-12 alkyl substituted by alkoxy, C 2-12 alkyl substituted by cyano, and C 2-12 cycloalkyl containing 1-3 heteroatoms selected from N, O and S; R 6 is selected from the group consisting of H, C 1-12 alkyl, C 1-12 alkyl substituted by hydroxy, halogen; R 7 is selected from H, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogens, C 1-12 alkyl substituted by hydroxy, C 2-12 alkyl substituted by cyano, C 2-12 cycloalkyl containing 1-3 hetero atoms selected from N, O and S, C 2-12 acyl, sulfonyl. R 1, R 2, R 3 and R 4 are each independently selected from H, halogen, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogen; R 5 is selected from H, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogens, C 1-12 alkyl substituted by hydroxy, C 2-12 alkyl substituted by alkoxy, C 2-12 alkyl substituted by cyano, and C 2-12 cycloalkyl containing 1-3 heteroatoms selected from N, O and S; R 6 is selected from the group consisting of H, C 1-12 alkyl, C 1-12 alkyl substituted by hydroxy, halogen; R 7 is selected from H, C 1-12 alkyl, C 1-12 alkyl substituted by 1-6 halogens, C 1-12 alkyl substituted by hydroxy, C 2-12 alkyl substituted by cyano, C 2-12 cycloalkyl containing 1-3 hetero atoms selected from N, O and S, C 2-12 acyl, sulfonyl.
Method of manufacturing a pre-insulated pipe containing a covering pipe made of plastics material, a foamed insulation layer and an inner pipe which carries a medium, having the following manufacturing steps: • providing a covering pipe made of plastics material, • fitting spacers on the covering pipe in order to ensure the concentric arrangement of the covering pipe and the inner pipe, • securing the spacers to the covering pipe, • introducing the inner pipe into the covering pipe, wherein the inner pipe is guided by the spacers concentrically with respect to the covering pipe, • foaming the intermediate space between the covering pipe and inner pipe (2, 6), whereby the insulation layer is formed, characterized in that the spacers are removed after the foaming. • providing a covering pipe made of plastics material, • fitting spacers on the covering pipe in order to ensure the concentric arrangement of the covering pipe and the inner pipe, • securing the spacers to the covering pipe, • introducing the inner pipe into the covering pipe, wherein the inner pipe is guided by the spacers concentrically with respect to the covering pipe, • foaming the intermediate space between the covering pipe and inner pipe (2, 6), whereby the insulation layer is formed,
A method of operating a user equipment, UE, comprising: performing a channel measurement on a measurement resource for channel measurement within a time interval of length prs; performing periodic interference measurements on measurement resources within the time interval, wherein the periodic interference measurements are taken according to a period of length pim, where pim < prs; for each interference measurement, determining a quality value associated with the interference measurement and the channel measurement; determining a statistical measure based on the quality values; and transmitting the statistical measure to a network node in a channel state information, CSI, report. performing a channel measurement on a measurement resource for channel measurement within a time interval of length prs; performing periodic interference measurements on measurement resources within the time interval, wherein the periodic interference measurements are taken according to a period of length pim, where pim < prs; for each interference measurement, determining a quality value associated with the interference measurement and the channel measurement; determining a statistical measure based on the quality values; and transmitting the statistical measure to a network node in a channel state information, CSI, report.
Hydraulic-vibration damping device that can be incorporated into a hydraulic circuit forming a hydraulic clutch control, the device comprising: - a body, and - an insert housed at least partially in the body, the device extending along a longitudinal axis between an upstream end and a downstream end which are defined in relation to the direction in which a fluid circulates in the said hydraulic circuit, the device defining: - a first path formed in the insert, in the form of a screw the axis of which is the longitudinal axis of the device, the said path allowing the fluid present at the upstream end to reach the downstream end by travelling a first length through the device, and - at least one second path (26, 50) allowing the fluid present at the upstream end to reach the downstream end by travelling a second length through the device and without travelling the first path, the first length being greater than the second length, the device comprising a valve (30, 46) closing off the second path (26, 50) as long as the pressure difference across the said valve (30, 46) is below a predefined value. - a body, and - an insert housed at least partially in the body, - a first path formed in the insert, in the form of a screw the axis of which is the longitudinal axis of the device, the said path allowing the fluid present at the upstream end to reach the downstream end by travelling a first length through the device, and - at least one second path (26, 50) allowing the fluid present at the upstream end to reach the downstream end by travelling a second length through the device and without travelling the first path, the first length being greater than the second length,
Infusion method for producing a fibre-reinforced composite component having textile semi-finished products which in a mould that is open on one side are disposed in a chamber to be evacuated and form the composite component to be infiltrated by a matrix material, wherein at least one local gas-receiving space (54, 62) is formed between the composite component and a chamber wall (56, 68), said gas-receiving space (54, 62) being blocked in relation to the matrix material by way of at least one local gas-permeable membrane (58, 78) and volatile substances contained in the matrix material and/or in the construction (31; 61; 89) escaping into said gas-receiving space (54, 62) when infiltrating, characterized in that at least one dimensionally stable gas reservoir (64, 66) is disposed in the gas-receiving space (54, 62), and wherein the dimensionally stable gas reservoir (64, 66) has an open-pore material structure.
An STS (Ship-to-Shore) crane comprising a portal frame structure; a boom supported to a top part of the portal frame structure and having a portion intended to extend to a ship's side and a portion intended to extend to a quay side; a trolley adapted to move along the boom, supported by trolley rails arranged on it; a hoisting mechanism arranged on top of the boom and having a rope drum for hoisting ropes, whereby the hoisting ropes are routed from the rope drum through boom ends to the trolley; auxiliary trolleys (9, 10) arranged to move along the boom on both sides of the trolley to support and/or tighten the hoisting ropes; a drive mechanism (11, 12) and drive roping (13, 14) of the auxiliary trolleys (9, 10) for moving the auxiliary trolleys; and a folding joint on the boom portion intended to extend on the ship's side for folding up the folding portion of the boom extending to the direction of the ship from the folding joint, characterised in that there are auxiliary trolley rails arranged on the boom for supporting the auxiliary trolleys (9, 10) and for their movement, these auxiliary trolley rails being separate from the trolley rails; and in that the drive roping (13, 14) of the auxiliary trolleys (9, 10) is divided into two separate and independent drive ropings (13, 14) which have separate and independent drive mechanisms (11, 12) and which are on different sides of the folding joint on the boom. a portal frame structure; a boom supported to a top part of the portal frame structure and having a portion intended to extend to a ship's side and a portion intended to extend to a quay side; a trolley adapted to move along the boom, supported by trolley rails arranged on it; a hoisting mechanism arranged on top of the boom and having a rope drum for hoisting ropes, whereby the hoisting ropes are routed from the rope drum through boom ends to the trolley; auxiliary trolleys (9, 10) arranged to move along the boom on both sides of the trolley to support and/or tighten the hoisting ropes; a drive mechanism (11, 12) and drive roping (13, 14) of the auxiliary trolleys (9, 10) for moving the auxiliary trolleys; and a folding joint on the boom portion intended to extend on the ship's side for folding up the folding portion of the boom extending to the direction of the ship from the folding joint, characterised in that there are auxiliary trolley rails arranged on the boom for supporting the auxiliary trolleys (9, 10) and for their movement, these auxiliary trolley rails being separate from the trolley rails; and in that the drive roping (13, 14) of the auxiliary trolleys (9, 10) is divided into two separate and independent drive ropings (13, 14) which have separate and independent drive mechanisms (11, 12) and which are on different sides of the folding joint on the boom.
A surgical graft, comprising: a remodelable collagenous material, said remodelable collagenous material comprising a plurality of sheets disposed in a multilayer configuration, wherein said sheets are of collagenous extracellular matrix material sheets harvested intact from a mammalian source, and wherein said sheets are bonded to one another by lyophilization; at least one interweaving member; and wherein said at least one interweaving member is interwoven through said plurality of sheets of remodelable collagenous material such that said sheets are affixed together. a remodelable collagenous material, said remodelable collagenous material comprising a plurality of sheets disposed in a multilayer configuration, wherein said sheets are of collagenous extracellular matrix material sheets harvested intact from a mammalian source, and wherein said sheets are bonded to one another by lyophilization; at least one interweaving member; and
Device arranged for radiating UV and/or IR radiation to a human body, the device comprising an upright housing comprising one or more radiation units each including one or more radiation sources and one or more reflectors, said reflectors being covered by a first radiation transmitting wall and a second radiation transmitting wall, parallel to the first radiation transmitting wall and spaced apart from it; the device including a cooling circuit for cooling the radiation units and/or the first and/or the second radiation transmitting walls (6,7), comprising - a cooling channel inlet at the bottom part of the device, - a front cooling channel, extending from said channel inlet and including the space between said first and second radiation transmitting walls, and - a rear cooling channel, connected to the front cooling channel through an interconnection part at the top side of the device, including a space between the radiation units and the rear and/or side walls of the upright housing, - an exhaust ventilator at the bottom side of the device, the rear cooling channel being connected to said exhaust ventilator and arranged to remove, via a channel outlet, cooling air sucked by the ventilator into the cooling circuit via said channel inlet and flowing through the front and rear channels meanwhile cooling the radiation units, characterized by a double-acting protective valve arranged to close both the channel inlet and the channel outlet when the exhaust ventilator is off, and/or to open the channel inlet and the channel outlet when the exhaust ventilator is on. - a cooling channel inlet at the bottom part of the device, - a front cooling channel, extending from said channel inlet and including the space between said first and second radiation transmitting walls, and - a rear cooling channel, connected to the front cooling channel through an interconnection part at the top side of the device, including a space between the radiation units and the rear and/or side walls of the upright housing, - an exhaust ventilator at the bottom side of the device,
A washing tub of a dishwasher comprising two guide rails (2; 2') parallel to each other of a dish rack (3; 4), said dish rack (3; 4) being translationally mounted between a retracted position and an extracted position of the washing tub, said dish rack (3; 4) having a first edge adapted to slide on a first of said two guide rails between said retracted position and said extracted position, characterized in that said first guide rail comprises a stop, said first edge of said dish rack (3; 4) being provided with an unhooking device comprising a holding portion and an unlocking lever, said holding portion being integral with said dish rack (3; 4) and being adapted to abut against said stop of said first guide rail, said unlocking lever being pivotably mounted to said first edge of said dish rack (3; 4) and being adapted to act on said holding portion to disengage said holding portion from said position abutting against said stop of said first guide rail.
A light generating device comprising: - a light source comprising a light emitting surface, wherein the light source is configured to generate light source light, wherein the light emitting surface is configured in a light chamber; - wherein the light chamber is at least partly defined by a chamber wall, wherein the chamber wall comprises: (i) a first part, wherein the first part is transmissive for the light source light, wherein the first part has a first reflectance R1 for the light source light, and wherein the first part has a first part area; and (ii) one or more second parts, wherein each second part is transmissive for the light source light, has a second reflectance R2 for the light source light, and wherein the one or more second parts together have a second part area, wherein R1-R2 ≥ 20%, wherein 65% ≤ R1 < 100%, wherein the second part area is smaller than the first part area, and wherein 0.005 ≤ A2/A1 ≤ 0.05. - a light source comprising a light emitting surface, wherein the light source is configured to generate light source light, wherein the light emitting surface is configured in a light chamber; - wherein the light chamber is at least partly defined by a chamber wall, wherein the chamber wall comprises: (i) a first part, wherein the first part is transmissive for the light source light, wherein the first part has a first reflectance R1 for the light source light, and wherein the first part has a first part area; and (ii) one or more second parts, wherein each second part is transmissive for the light source light, has a second reflectance R2 for the light source light, and wherein the one or more second parts together have a second part area, wherein R1-R2 ≥ 20%, wherein 65% ≤ R1 < 100%, wherein the second part area is smaller than the first part area, and wherein 0.005 ≤ A2/A1 ≤ 0.05. (i) a first part, wherein the first part is transmissive for the light source light, wherein the first part has a first reflectance R1 for the light source light, and wherein the first part has a first part area; and (ii) one or more second parts, wherein each second part is transmissive for the light source light, has a second reflectance R2 for the light source light, and wherein the one or more second parts together have a second part area, wherein R1-R2 ≥ 20%, wherein 65% ≤ R1 < 100%, wherein the second part area is smaller than the first part area, and wherein 0.005 ≤ A2/A1 ≤ 0.05.
A method performed in a control device for controlling a power compensation arrangement comprising a voltage source converter and one or more power compensation branches (4, 5, 8), each power compensation branch (4, 5, 8) comprising a thyristor controlled reactor, a thyristor switched reactor or a thyristor controlled capacitor, the voltage source converter and the one or more power compensation branches (4, 5, 8) being connected to a same busbar, the method comprising: - detecting a request in an electrical power system to which the power compensation arrangement is connected, characterized in that it comprises - determining, based on the request, a need for reactive power supply to the electrical power system to be larger than a reactive power capacity of the voltage source converter or determined to minimize total losses of the power compensation arrangement, - providing reactive power by means of the voltage source converter and by one or more of the power compensation branches (4, 5, 8), and - compensating, by means of the voltage source converter, any disturbances caused by the power compensation branches (4, 5, 8) when providing the reactive power to the electrical power system. - detecting a request in an electrical power system to which the power compensation arrangement is connected, characterized in that it comprises - determining, based on the request, a need for reactive power supply to the electrical power system to be larger than a reactive power capacity of the voltage source converter or determined to minimize total losses of the power compensation arrangement, - providing reactive power by means of the voltage source converter and by one or more of the power compensation branches (4, 5, 8), and - compensating, by means of the voltage source converter, any disturbances caused by the power compensation branches (4, 5, 8) when providing the reactive power to the electrical power system. - determining, based on the request, a need for reactive power supply to the electrical power system to be larger than a reactive power capacity of the voltage source converter or determined to minimize total losses of the power compensation arrangement, - providing reactive power by means of the voltage source converter and by one or more of the power compensation branches (4, 5, 8), and - compensating, by means of the voltage source converter, any disturbances caused by the power compensation branches (4, 5, 8) when providing the reactive power to the electrical power system.