An in-vitro lateral flow device for detecting in a sample neurotoxins or ligands of an ion-channel-linked receptor, and/or a voltage gated ion-channel comprising: - a zone for depositing a sample; - a zone comprising ∘ a conjugate comprising an enzyme coupled to a molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising an enzyme coupled to a molecule which binds to an antibody directed against the neurotoxin binding site of the ion-channel-linked receptor and/or of the voltage gated ion-channel, and/or ∘ a conjugate comprising a nanogold coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a carbon-black coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a fluorescent molecule that binds to a tagged ligand of an ion-channel-linked receptor and/or a voltage gated ion-channel - a visualizing zone comprising ∘ a test zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel fixed on the test surface, and ∘ a control zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel bound with a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ion-channel-linked receptor and/or a voltage gated ion-channel being fixed on the test surface or ∘ a control zone comprising a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ligand being fixed directly on the test surface and - an absorption zone wherein zones and overlap at one of their ends, the other end of zone overlaps with one end of zone and absorption zone overlaps with the free end of the zone, and wherein the test surface is a glass fiber support or a test surface selected from the group comprising nitrocellulose membranes, mixed cellulose ester membranes, cellulose acetate membranes, hydrophilic PTFE membranes, nylon or polycarbonate membranes of high porosity. - a zone for depositing a sample; - a zone comprising ∘ a conjugate comprising an enzyme coupled to a molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising an enzyme coupled to a molecule which binds to an antibody directed against the neurotoxin binding site of the ion-channel-linked receptor and/or of the voltage gated ion-channel, and/or ∘ a conjugate comprising a nanogold coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a carbon-black coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a fluorescent molecule that binds to a tagged ligand of an ion-channel-linked receptor and/or a voltage gated ion-channel ∘ a conjugate comprising an enzyme coupled to a molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising an enzyme coupled to a molecule which binds to an antibody directed against the neurotoxin binding site of the ion-channel-linked receptor and/or of the voltage gated ion-channel, and/or ∘ a conjugate comprising a nanogold coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a carbon-black coated molecule which binds to a tagged ligand of an ion-channel-linked receptor, and/or a voltage gated ion-channel, or ∘ a conjugate comprising a fluorescent molecule that binds to a tagged ligand of an ion-channel-linked receptor and/or a voltage gated ion-channel - a visualizing zone comprising ∘ a test zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel fixed on the test surface, and ∘ a control zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel bound with a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ion-channel-linked receptor and/or a voltage gated ion-channel being fixed on the test surface or ∘ a control zone comprising a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ligand being fixed directly on the test surface and ∘ a test zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel fixed on the test surface, and ∘ a control zone comprising fragmented and isolated cell membranes comprising an ion-channel-linked receptor and/or a voltage gated ion-channel bound with a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ion-channel-linked receptor and/or a voltage gated ion-channel being fixed on the test surface or ∘ a control zone comprising a tagged ligand of the ion-channel-linked receptor and/or of the voltage gated ion-channel, said ligand being fixed directly on the test surface - an absorption zone