A method for preparing a 2,5-disubstituted furan compound, wherein the 2,5-disubstituted furan compound is prepared by reacting 2,3-dicarboxylic anhydride-7-oxabicyclo[2.2.1]hept-5-ene and/or furan with an acylating reagent, wherein the acylating reagent is an anhydride and/or an acyl halide, wherein the anhydride is at least one selected from the compounds with the chemical structure formula represented by Formula I: wherein, R 1 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 1 is a group which is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; R 2 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 2 is a group which is selected from groups with carbon atoms from 1 to 20 carbon atoms and comprising at least one group selected from halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; wherein the acyl halide is at least one selected from the compounds with the chemical structure formula represented by Formula II: wherein, R 3 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 3 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; and X is selected from fluorine, chlorine, bromine, iodine, wherein the 2,5-disubstituted furan compound is at least one selected from the compounds with the chemical structure formula represented by Formula IV: wherein, R 5 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 5 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; R 6 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 6 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group. wherein the acylating reagent is an anhydride and/or an acyl halide, wherein the anhydride is at least one selected from the compounds with the chemical structure formula represented by Formula I: wherein, R 1 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 1 is a group which is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; R 2 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 2 is a group which is selected from groups with carbon atoms from 1 to 20 carbon atoms and comprising at least one group selected from halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; wherein the acyl halide is at least one selected from the compounds with the chemical structure formula represented by Formula II: wherein, R 3 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 3 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; and X is selected from fluorine, chlorine, bromine, iodine, wherein the 2,5-disubstituted furan compound is at least one selected from the compounds with the chemical structure formula represented by Formula IV: wherein, R 5 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 5 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group; R 6 is hydrogen or an alkyl group with carbon atoms from 1 to 20; or R 6 is selected from groups with carbon atoms from 1 to 20 and comprising at least one group selected from the list consisting of halogen, aryl, heteroaryl, carbonyl, aliphatic group, nitrile group.