Device for negative pressure wound therapy comprising (a) a cover material for an airtight enclosure of the wound and its surroundings; (b) means suitable for generating negative pressure in the wound space; and (c) an open-cell, crosslinked silicone-containing polyurethane foam as a wound dressing, wherein the silicone-containing polyurethane foam (c) is obtainable by a reaction of a curable mixture comprising the components (i) polyisocyanate (ii) siloxane of Formula wherein R 1, R 2, R 3, R 4, R 5, and R 6 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, R 7 and R 8 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, under the condition that at least one of radicals R 7 and R 8 has at least one hydroxyl or thiol group, Z and Z' are independently oxygen or sulfur, L and L' are independently a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms, wherein one of the carbon atoms thereof may be replaced by oxygen such that there is an ether bond, or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms and optionally containing a heteroatom, G is a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, optionally containing a heteroatom, q is an integer from 1 to 100, r is an integer from 1 to 10. (a) a cover material for an airtight enclosure of the wound and its surroundings; (b) means suitable for generating negative pressure in the wound space; and (c) an open-cell, crosslinked silicone-containing polyurethane foam as a wound dressing, (i) polyisocyanate (ii) siloxane of Formula wherein R 1, R 2, R 3, R 4, R 5, and R 6 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, R 7 and R 8 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, under the condition that at least one of radicals R 7 and R 8 has at least one hydroxyl or thiol group, Z and Z' are independently oxygen or sulfur, L and L' are independently a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms, wherein one of the carbon atoms thereof may be replaced by oxygen such that there is an ether bond, or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms and optionally containing a heteroatom, G is a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, optionally containing a heteroatom, q is an integer from 1 to 100, r is an integer from 1 to 10. R 1, R 2, R 3, R 4, R 5, and R 6 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, R 7 and R 8 are independently hydrogen, a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 8 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, under the condition that at least one of radicals R 7 and R 8 has at least one hydroxyl or thiol group, Z and Z' are independently oxygen or sulfur, L and L' are independently a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms, wherein one of the carbon atoms thereof may be replaced by oxygen such that there is an ether bond, or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms and optionally containing a heteroatom, G is a substituted or unsubstituted aliphatic hydrocarbon radical having 1 to 6 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon radical having 6 to 12 carbon atoms, optionally containing a heteroatom, q is an integer from 1 to 100, r is an integer from 1 to 10.