A method for generating 44 Sc from a target solution, comprising the following steps: - a step of solid-liquid extraction comprising:. (a) the precipitation of a target solution comprising metal species with fluoride ions, said target solution comprising at least 44 Sc, 44 Ti, and 46 Sc and other metal impurities, wherein the amount of Sc is from 10,000 to 15 000 ppm in relation to the total weight of said target solution, the amount of Ti is from 5 to 10 ppm in relation to the total weight of said target solution, and the amount of each metal impurity is from 200 to 300 ppm in relation to the total volume of said target solution, whereby a solution comprising a precipitate made essentially of 46 Sc is obtained,. (b) the filtration of the resulting solution and the recovering of the resulting filtrate comprising essentially 44 Sc and 44 Ti; - a step of solid-phase extraction chromatography comprising:. (c) the loading of the filtrate obtained by the previous step onto a preconditioned hydroxamate column, wherein said preconditioned hydroxamate column is obtained from the treatment of a hydroxamate column with a strong acid and rinsing with water, and. (d) the elution of a hydrochloric acid solution through the preconditioned hydroxamate column, whereby 44 Ti is adsorbed onto said column, and - a step of recovering 44 Sc from the elution of the previous step. - a step of solid-liquid extraction comprising:. (a) the precipitation of a target solution comprising metal species with fluoride ions, said target solution comprising at least 44 Sc, 44 Ti, and 46 Sc and other metal impurities, wherein the amount of Sc is from 10,000 to 15 000 ppm in relation to the total weight of said target solution, the amount of Ti is from 5 to 10 ppm in relation to the total weight of said target solution, and the amount of each metal impurity is from 200 to 300 ppm in relation to the total volume of said target solution, whereby a solution comprising a precipitate made essentially of 46 Sc is obtained,. (b) the filtration of the resulting solution and the recovering of the resulting filtrate comprising essentially 44 Sc and 44 Ti;. (a) the precipitation of a target solution comprising metal species with fluoride ions, said target solution comprising at least 44 Sc, 44 Ti, and 46 Sc and other metal impurities, wherein the amount of Sc is from 10,000 to 15 000 ppm in relation to the total weight of said target solution, the amount of Ti is from 5 to 10 ppm in relation to the total weight of said target solution, and the amount of each metal impurity is from 200 to 300 ppm in relation to the total volume of said target solution, whereby a solution comprising a precipitate made essentially of 46 Sc is obtained,. (b) the filtration of the resulting solution and the recovering of the resulting filtrate comprising essentially 44 Sc and 44 Ti; - a step of solid-phase extraction chromatography comprising:. (c) the loading of the filtrate obtained by the previous step onto a preconditioned hydroxamate column, wherein said preconditioned hydroxamate column is obtained from the treatment of a hydroxamate column with a strong acid and rinsing with water, and. (d) the elution of a hydrochloric acid solution through the preconditioned hydroxamate column, whereby 44 Ti is adsorbed onto said column, and. (c) the loading of the filtrate obtained by the previous step onto a preconditioned hydroxamate column, wherein said preconditioned hydroxamate column is obtained from the treatment of a hydroxamate column with a strong acid and rinsing with water, and. (d) the elution of a hydrochloric acid solution through the preconditioned hydroxamate column, whereby 44 Ti is adsorbed onto said column, and - a step of recovering 44 Sc from the elution of the previous step.