A system to measure temperature in a region of interest, comprising: an instrument assembly including: an exterior housing having an external wall defining an internal closed blind bore extending a first length from a first housing end to a second closed housing end and configured to be moved to a position within a volume, and an energy delivery component extending a second length from a first energy delivery component end to a second energy delivery component end and configured to be moved to a position within a volume and deliver energy to affect a thermal therapy at a region of interest within the volume and outside of the exterior housing, wherein the energy delivery component is moveable within the exterior housing; a first temperature sensor embedded within the external wall of the exterior housing and fixed near the first energy delivery component end and wherein the first temperature sensor is configured to sense a temperature within the region of interest outside of the exterior housing and spaced a distance away from the external surface of the housing; an energy source configured to deliver energy through the energy delivery component to affect the thermal therapy in the region of interest outside the exterior housing; a tracking device fixed near the first energy delivery component end; and a processor configured to execute instructions to: determine a temperature profile within the region of interest based on a signal from the first temperature sensor, and determine a position of the instrument within the region of interest; wherein the thermal therapy is operable to increase a temperature in the region of interest outside the exterior housing. an instrument assembly including: an exterior housing having an external wall defining an internal closed blind bore extending a first length from a first housing end to a second closed housing end and configured to be moved to a position within a volume, and an energy delivery component extending a second length from a first energy delivery component end to a second energy delivery component end and configured to be moved to a position within a volume and deliver energy to affect a thermal therapy at a region of interest within the volume and outside of the exterior housing, wherein the energy delivery component is moveable within the exterior housing; an exterior housing having an external wall defining an internal closed blind bore extending a first length from a first housing end to a second closed housing end and configured to be moved to a position within a volume, and an energy delivery component extending a second length from a first energy delivery component end to a second energy delivery component end and configured to be moved to a position within a volume and deliver energy to affect a thermal therapy at a region of interest within the volume and outside of the exterior housing, wherein the energy delivery component is moveable within the exterior housing; a first temperature sensor embedded within the external wall of the exterior housing and fixed near the first energy delivery component end and wherein the first temperature sensor is configured to sense a temperature within the region of interest outside of the exterior housing and spaced a distance away from the external surface of the housing; an energy source configured to deliver energy through the energy delivery component to affect the thermal therapy in the region of interest outside the exterior housing; a tracking device fixed near the first energy delivery component end; and a processor configured to execute instructions to: determine a temperature profile within the region of interest based on a signal from the first temperature sensor, and determine a position of the instrument within the region of interest; determine a temperature profile within the region of interest based on a signal from the first temperature sensor, and determine a position of the instrument within the region of interest; wherein the thermal therapy is operable to increase a temperature in the region of interest outside the exterior housing.