A cell analysis system, comprising: a body adapted to selectively receive a disposable fluidic cartridge (14, 100), wherein the disposable fluidic cartridge (14, 100) includes a blood receiving port for receiving a whole blood sample, a red blood cell flow cytometry analysis channel adapted to hydrodynamically focus a sample fluid in the red blood cell flow cytometry analysis channel, a white blood cell flow cytometry analysis channel adapted to hydrodynamically focus a sample fluid in the white blood cell flow cytometry analysis channel, a branch for partitioning the whole blood sample received through the blood receiving port into the red blood cell flow cytometry analysis channel and the white blood cell flow cytometry analysis channel, and wherein the white blood cell flow cytometry analysis channel includes an intersecting region configured to receive a lysing reagent to lyse the whole blood sample; a first light source for providing a first light beam to at least part of the sample fluid in the red blood cell flow cytometry analysis channel; one or more first detectors for receiving at least some of the first light beam that passes through the sample fluid in the red blood cell flow cytometry analysis channel and for providing one or more first detector output signals; a second light source for providing a second light beam to at least part of the sample fluid in the white blood cell flow cytometry analysis channel; one or more second detectors for receiving at least some of the second light beam that passes through the sample fluid in the white blood cell flow cytometry analysis channel and for providing one or more second detector output signals; and a processing block coupled to the one or more first detector output signals and the one or more second detector output signals. a body adapted to selectively receive a disposable fluidic cartridge (14, 100), wherein the disposable fluidic cartridge (14, 100) includes a blood receiving port for receiving a whole blood sample, a red blood cell flow cytometry analysis channel adapted to hydrodynamically focus a sample fluid in the red blood cell flow cytometry analysis channel, a white blood cell flow cytometry analysis channel adapted to hydrodynamically focus a sample fluid in the white blood cell flow cytometry analysis channel, a branch for partitioning the whole blood sample received through the blood receiving port into the red blood cell flow cytometry analysis channel and the white blood cell flow cytometry analysis channel, and wherein the white blood cell flow cytometry analysis channel includes an intersecting region configured to receive a lysing reagent to lyse the whole blood sample; a first light source for providing a first light beam to at least part of the sample fluid in the red blood cell flow cytometry analysis channel; one or more first detectors for receiving at least some of the first light beam that passes through the sample fluid in the red blood cell flow cytometry analysis channel and for providing one or more first detector output signals; a second light source for providing a second light beam to at least part of the sample fluid in the white blood cell flow cytometry analysis channel; one or more second detectors for receiving at least some of the second light beam that passes through the sample fluid in the white blood cell flow cytometry analysis channel and for providing one or more second detector output signals; and a processing block coupled to the one or more first detector output signals and the one or more second detector output signals.