An in-vivo glucose monitoring and management system, comprising: an analyte sensor for monitoring an analyte level; and a transmitter, the transmitter comprising: a data stream generator that generates a data stream associated with the monitored analyte level; a radio frequency logic portion operatively coupled to the data stream generator, the radio frequency logic portion configured to generate a radio frequency data stream based on the data stream generated from the data stream generator, characterised in that the radio frequency logic portion further includes one or more finite state machines and a plurality of discrete digital logic circuits, the one or more finite state machines configured to control the plurality of digital logic circuits to generate the radio frequency data stream for wireless communication; and a radio frequency communication component, wherein the one or more finite state machines include a transmit state machine, wherein the transmit state machine is configured to issue a build packet command to the radio frequency logic portion to control the generation of the radio frequency data stream and to build a data packet based on the monitored analyte level from the analyte sensor, and to issue a send packet command to the radio frequency logic portion to transmit the data packet to the radio frequency communication component for communication to a remote location. an analyte sensor for monitoring an analyte level; and a transmitter, the transmitter comprising: a data stream generator that generates a data stream associated with the monitored analyte level; a radio frequency logic portion operatively coupled to the data stream generator, the radio frequency logic portion configured to generate a radio frequency data stream based on the data stream generated from the data stream generator, characterised in that the radio frequency logic portion further includes one or more finite state machines and a plurality of discrete digital logic circuits, the one or more finite state machines configured to control the plurality of digital logic circuits to generate the radio frequency data stream for wireless communication; and a radio frequency communication component, a data stream generator that generates a data stream associated with the monitored analyte level; a radio frequency logic portion operatively coupled to the data stream generator, the radio frequency logic portion configured to generate a radio frequency data stream based on the data stream generated from the data stream generator, characterised in that the radio frequency logic portion further includes one or more finite state machines and a plurality of discrete digital logic circuits, the one or more finite state machines configured to control the plurality of digital logic circuits to generate the radio frequency data stream for wireless communication; and a radio frequency communication component, wherein the one or more finite state machines include a transmit state machine, wherein the transmit state machine is configured to issue a build packet command to the radio frequency logic portion to control the generation of the radio frequency data stream and to build a data packet based on the monitored analyte level from the analyte sensor, and to issue a send packet command to the radio frequency logic portion to transmit the data packet to the radio frequency communication component for communication to a remote location.