A system for simultaneously treating a plurality of tissue sites on a patient, the system comprising: a plurality of reduced-pressure dressings; a plurality of multi-lumen reduced-pressure delivery conduits, wherein each multi-lumen reduced-pressure delivery conduit includes at least a pressure-sampling lumen and at least a reduced-pressure supply lumen; a multi-port therapy unit comprising: a plurality of patient-side ports, wherein each of the plurality of patient-side ports is configured to fluidly couple with one of the plurality of multi-lumen reduced-pressure delivery conduits and with at least one of the pressure-sampling lumens and one of the reduced-pressure supply lumens therein, a single fluid reservoir fluidly coupled to the plurality of patient-side ports, a plurality of pressure sensors, wherein the plurality of pressure sensors are associated with the plurality of patient-side ports for determining a pressure associated with each of the plurality of pressure-sampling lumens, a controller operatively coupled to the plurality of pressure sensors for receiving treatment pressure data from the plurality of pressure sensors, wherein the controller comprises a microprocessor and memory configured to monitor pressure for each of the plurality of pressure sensors and to signal an alarm condition if the pressure is outside of a pre-selected range, an electrical source operatively coupled to the controller, a single supply-side port for receiving reduced pressure, wherein the supply-side port is fluidly coupled to the single fluid reservoir, and an alarm indicator operatively coupled to the controller for indicating when the controller signals an alarm condition; and a reduced-pressure source fluidly coupled to the single supply-side port. a plurality of reduced-pressure dressings; a plurality of multi-lumen reduced-pressure delivery conduits, wherein each multi-lumen reduced-pressure delivery conduit includes at least a pressure-sampling lumen and at least a reduced-pressure supply lumen; a multi-port therapy unit comprising: a plurality of patient-side ports, wherein each of the plurality of patient-side ports is configured to fluidly couple with one of the plurality of multi-lumen reduced-pressure delivery conduits and with at least one of the pressure-sampling lumens and one of the reduced-pressure supply lumens therein, a single fluid reservoir fluidly coupled to the plurality of patient-side ports, a plurality of pressure sensors, wherein the plurality of pressure sensors are associated with the plurality of patient-side ports for determining a pressure associated with each of the plurality of pressure-sampling lumens, a controller operatively coupled to the plurality of pressure sensors for receiving treatment pressure data from the plurality of pressure sensors, wherein the controller comprises a microprocessor and memory configured to monitor pressure for each of the plurality of pressure sensors and to signal an alarm condition if the pressure is outside of a pre-selected range, an electrical source operatively coupled to the controller, a single supply-side port for receiving reduced pressure, wherein the supply-side port is fluidly coupled to the single fluid reservoir, and an alarm indicator operatively coupled to the controller for indicating when the controller signals an alarm condition; and a plurality of patient-side ports, wherein each of the plurality of patient-side ports is configured to fluidly couple with one of the plurality of multi-lumen reduced-pressure delivery conduits and with at least one of the pressure-sampling lumens and one of the reduced-pressure supply lumens therein, a single fluid reservoir fluidly coupled to the plurality of patient-side ports, a plurality of pressure sensors, wherein the plurality of pressure sensors are associated with the plurality of patient-side ports for determining a pressure associated with each of the plurality of pressure-sampling lumens, a controller operatively coupled to the plurality of pressure sensors for receiving treatment pressure data from the plurality of pressure sensors, wherein the controller comprises a microprocessor and memory configured to monitor pressure for each of the plurality of pressure sensors and to signal an alarm condition if the pressure is outside of a pre-selected range, an electrical source operatively coupled to the controller, a single supply-side port for receiving reduced pressure, wherein the supply-side port is fluidly coupled to the single fluid reservoir, and an alarm indicator operatively coupled to the controller for indicating when the controller signals an alarm condition; and a reduced-pressure source fluidly coupled to the single supply-side port.