mhurhangee/ep-ind-claims huggingface dataset:
A self-assembling compound having formula: or a salt, solvate, polymorph or stereoisomer thereof, for the use in treating, managing or preventing a human disease that is related to the abnormal membrane potential responses selected from a group comprising autosomal-dominant long-QT syndrome with deafness, autosomal-recessive long-QT syndrome, benign familial neonatal convulsions, Long-QT syndrome, Long-QT syndrome with dysmorphic features, generalised epilepsy with febrile seizures (GEFS+), generalised epilepsy with febrile and afebrile seizures, paramyotonia congenita, potassium-aggravated myotonia, hyperkalaemic periodic paralysis, Brugada syndrome; wherein X is an unsubstituted or substituted hydrocarbyl or heterocyclyl; n is an integer from 2 or 3; Y is a divalent or trivalent linking group formed by removing two or three hydrogen atoms respectively from an unsubstituted or substituted alkane, alkene or alkyne, from an unsubstituted or substituted monocyclic, bicyclic or tricyclic aromatic carbocycle or from an unsubstituted or substituted monocyclic, bicyclic or tricyclic heterocycle; and H DA is a divalent group having the formula,, (IIIA), (IIIB), (IIIC), (IIID), (IIIE), or: wherein each of Z 1 and Z 2 is independently O, S or NR 1; each of A, B 2, and D is independently a bond, O, S, NR 2 or a substituted or unsubstituted C 1-10 alkylene; each of B 1 and B 3 is independently a bond, O, S, NR 2 or a substituted or unsubstituted C 1-10 alkylene; k is an integer from 1 to 20, where each of R 1 and R 2 is independently H, acyl, hydrocarbyl, carbocyclyl or heterocyclyl and at least one of B 1 and B 2 of formula is NH. wherein each of Z 1 and Z 2 is independently O, S or NR 1; each of A, B 2, and D is independently a bond, O, S, NR 2 or a substituted or unsubstituted C 1-10 alkylene; each of B 1 and B 3 is independently a bond, O, S, NR 2 or a substituted or unsubstituted C 1-10 alkylene; k is an integer from 1 to 20, where each of R 1 and R 2 is independently H, acyl, hydrocarbyl, carbocyclyl or heterocyclyl and at least one of B 1 and B 2 of formula is NH.
A power conversion system, comprising: an AC input coupleable to receive AC input power from a power source; a rectifier, including a plurality of AC input terminals (U, V, W), first and second DC output terminals (DC+, DC-), and a plurality of switching devices (Q1,..., Q6) individually coupled between a corresponding one of the AC input terminals and one of the first and second DC output terminals; a filter circuit coupled between the AC input and the rectifier; and a controller to provide switching control signals to operate the switching devices of the rectifier, the controller operative in a first mode to: turn a single one of the switching devices on for a non-zero time period in order to short a pair of feeder lines (A, C) connected with the power source, turn the single one of the switching devices off after the non-zero time period, measure a voltage (Vca,b,c) or current signal (I1a,b,c; Ifa,b,c) associated with the filter circuit while all of the switching devices (Q1,..., Q6) are off after the non-zero time period, determine a resonant frequency (ω res) based on a transient response of the measured voltage or current signal, and selectively adjust a rectifier control parameter to mitigate filter resonance based on the resonant frequency. an AC input coupleable to receive AC input power from a power source; a rectifier, including a plurality of AC input terminals (U, V, W), first and second DC output terminals (DC+, DC-), and a plurality of switching devices (Q1,..., Q6) individually coupled between a corresponding one of the AC input terminals and one of the first and second DC output terminals; a filter circuit coupled between the AC input and the rectifier; and a controller to provide switching control signals to operate the switching devices of the rectifier, the controller operative in a first mode to: turn a single one of the switching devices on for a non-zero time period in order to short a pair of feeder lines (A, C) connected with the power source, turn the single one of the switching devices off after the non-zero time period, measure a voltage (Vca,b,c) or current signal (I1a,b,c; Ifa,b,c) associated with the filter circuit while all of the switching devices (Q1,..., Q6) are off after the non-zero time period, determine a resonant frequency (ω res) based on a transient response of the measured voltage or current signal, and selectively adjust a rectifier control parameter to mitigate filter resonance based on the resonant frequency. turn a single one of the switching devices on for a non-zero time period in order to short a pair of feeder lines (A, C) connected with the power source, turn the single one of the switching devices off after the non-zero time period, measure a voltage (Vca,b,c) or current signal (I1a,b,c; Ifa,b,c) associated with the filter circuit while all of the switching devices (Q1,..., Q6) are off after the non-zero time period, determine a resonant frequency (ω res) based on a transient response of the measured voltage or current signal, and selectively adjust a rectifier control parameter to mitigate filter resonance based on the resonant frequency.
Archimedes' screw device for a hydraulic power plant, including an assembly comprising two concentric tubes (2, 3) made integral with each other by a helix arranged helically between said two tubes (2, 3), and positioned inclined below a waterfall, the water, by passing by gravity between the two tubes (2, 3), causing said assembly to rotate, said assembly being carried on the one hand, in its upper portion, by a bearing, in which the end of the inner tube can journal, and on the other hand, in its lower portion, through a cradle, in which the outer tube rests, wherein the helical helix (4, 5, 6) is formed of two threads (P, S), one radial and the other one oblique with respect to the axis of the screw.
A high strength spring containing, by mass%, C: 0.40 to 0.50%, Si: 1.00 to 3.00%, Mn: 0.30 to 1.20%, Ni: 0.05 to 0.50%, Cr: 0.35 to 1.50%, Mo: 0.03 to 0.50%, Cu: 0.05 to 0.50%, Al: 0.005 to 0.100%, V: 0.05 to 0.50%, Nb: 0.005 to 0.150%, N: 0.0100 to 0.0200%, P: limited to be less than or equal to 0.015%, S: limited to be less than or equal to 0.010%, and the balance of Fe and inevitable impurities, wherein a Nb-compound including at least one of Nb-carbide, Nb-nitride and Nb-carbonitride is included, and wherein a V-compound including at least one of V-carbide and V-carbonitride that is precipitated around the Nb-compound is included, and wherein the number of the complex precipitates, formed by the Nb-compound and the V-compound precipitated around the Nb-compound, per unit is greater than or equal to 100/mm 2 and less than or equal to 100 000/mm 2.
A process which comprises: (a) heating a composition comprising recycled polyethylene terephthalate (rPET) with a C 3 -C 10 glycol reactant to give a digested intermediate comprising glycols and a terephthalate component, wherein the terephthalate component comprises, by gel permeation chromatography using ultraviolet detection, 45 to 70 wt.% of bis(hydroxyalkyl)terephthalates; and (b) treating the digested intermediate with activated carbon under conditions effective to give the polyester polyol; wherein the molar ratio of C 3 -C 10 glycol reactant to rPET is at least 2.0, and the polyester polyol has a hydroxyl number within the range of 25 to 800 mg KOH/g and a color index less than 20, where color index is defined by 100 x (|a*|/L*) as measured by CIE colorimetric analysis. (a) heating a composition comprising recycled polyethylene terephthalate (rPET) with a C 3 -C 10 glycol reactant to give a digested intermediate comprising glycols and a terephthalate component, wherein the terephthalate component comprises, by gel permeation chromatography using ultraviolet detection, 45 to 70 wt.% of bis(hydroxyalkyl)terephthalates; and (b) treating the digested intermediate with activated carbon under conditions effective to give the polyester polyol;
An apparatus for driving a Micro Electro Mechanical System, MEMS, structure and detecting motion of the driven MEMS structure, comprising: a driving signal generation part for generating and outputting a first driving signal to drive the MEMS structure; a motion detection part for detecting the motion of the MEMS structure driven according to the first driving signal and outputting a motion current signal corresponding to the motion of the MEMS structure; characterized in that said motion detection part comprises one single variable capacitor comprising a movable electrode plate integral to a movable MEMS structure and a fixed electrode plate disposed opposite to the movable electrode plate, wherein the movable electrode plate is supplied with the first driving signal and the fixed electrode plate is virtually grounded; an amplification part for amplifying the motion current signal output from the motion detection part and outputting a motion voltage signal; a gain adjustment part for amplifying the first driving signal input from the driving signal generation part and outputting a second driving signal amplified by a predetermined gain; a differential circuit part for performing adding and subtracting operations with respect to the motion voltage signal output from the amplification part and the second driving signal output from the gain adjustment part and outputting a motion signal without the second driving signal; and a motion signal detection part for selecting and outputting a motion signal of a predetermined frequency out of the motion signal output from the differential circuit part. a driving signal generation part for generating and outputting a first driving signal to drive the MEMS structure; a motion detection part for detecting the motion of the MEMS structure driven according to the first driving signal and outputting a motion current signal corresponding to the motion of the MEMS structure; characterized in that said motion detection part comprises one single variable capacitor comprising a movable electrode plate integral to a movable MEMS structure and a fixed electrode plate disposed opposite to the movable electrode plate, wherein the movable electrode plate is supplied with the first driving signal and the fixed electrode plate is virtually grounded; an amplification part for amplifying the motion current signal output from the motion detection part and outputting a motion voltage signal; a gain adjustment part for amplifying the first driving signal input from the driving signal generation part and outputting a second driving signal amplified by a predetermined gain; a differential circuit part for performing adding and subtracting operations with respect to the motion voltage signal output from the amplification part and the second driving signal output from the gain adjustment part and outputting a motion signal without the second driving signal; and a motion signal detection part for selecting and outputting a motion signal of a predetermined frequency out of the motion signal output from the differential circuit part.
A device for transmitting broadband pulsed mechanical waves, comprising: a mechanical waveguide (200; 400) having an elongated shape and extending between a proximal end and a distal end, the proximal end being operatively couplable to a mechanical wave pulse generator for propagating the broadband pulsed mechanical waves from the proximal end up to the distal end of the mechanical waveguide, the mechanical waveguide having at least two protrusions (216, 218, 402, 403) projecting from an outer face thereof adjacent to the distal end; a radiopaque marker (202; 404) secured to the mechanical waveguide adjacent to the distal end thereof, the radiopaque marker being hollow and positioned over the mechanical waveguide between the two protrusions; and wherein an inner dimension of the radiopaque marker is greater than an outer dimension (hl, h2) of a section of the mechanical waveguide between the two protrusions once the radiopaque marker is positioned between the two protrusions and deformed about the section of the mechanical waveguide so as to minimize leakage of the broadband pulsed mechanical waves. a mechanical waveguide (200; 400) having an elongated shape and extending between a proximal end and a distal end, the proximal end being operatively couplable to a mechanical wave pulse generator for propagating the broadband pulsed mechanical waves from the proximal end up to the distal end of the mechanical waveguide, the mechanical waveguide having at least two protrusions (216, 218, 402, 403) projecting from an outer face thereof adjacent to the distal end; a radiopaque marker (202; 404) secured to the mechanical waveguide adjacent to the distal end thereof, the radiopaque marker being hollow and positioned over the mechanical waveguide between the two protrusions; and wherein an inner dimension of the radiopaque marker is greater than an outer dimension (hl, h2) of a section of the mechanical waveguide between the two protrusions once the radiopaque marker is positioned between the two protrusions and deformed about the section of the mechanical waveguide so as to minimize leakage of the broadband pulsed mechanical waves.
System composed of cooktop (11, 311) and monitoring device (30, 230, 330), the cooktop comprising: - a cooktop surface (12, 312), - at least one heating device (17, 317) under the cooktop surface, - a cooktop control, wherein the monitoring device (30, 230, 330) includes: - an energy store (38, 338) of its own, - sensor means (43, 44, 45, 143, 144, 145, 243, 244, 245, 343, 344), in order to detect a cooking vessel placed on the cooktop surface and/or its temperature and/or its size, - a communication device (40, 340) for communication with an operator and/or the cooktop control, wherein in the second case the cooktop control has a corresponding communication device, a drive device (33, 334, 335), with which the monitoring device is self-propelled, characterized in that the monitoring device: - is freely movable and self-propelled, - is not fixedly connected to the cooktop surface (12, 312) and removable from it, - is designed to move freely on the cooktop surface, - has a control (36, 336) of its own, - has at least one position sensor (24a, 24b) for determining a position and/or a change in position of the monitoring device on the cooktop surface. - a cooktop surface (12, 312), - at least one heating device (17, 317) under the cooktop surface, - a cooktop control, wherein the monitoring device (30, 230, 330) includes: - an energy store (38, 338) of its own, - sensor means (43, 44, 45, 143, 144, 145, 243, 244, 245, 343, 344), in order to detect a cooking vessel placed on the cooktop surface and/or its temperature and/or its size, - a communication device (40, 340) for communication with an operator and/or the cooktop control, wherein in the second case the cooktop control has a corresponding communication device, a drive device (33, 334, 335), with which the monitoring device is self-propelled, - is freely movable and self-propelled, - is not fixedly connected to the cooktop surface (12, 312) and removable from it, - is designed to move freely on the cooktop surface, - has a control (36, 336) of its own, - has at least one position sensor (24a, 24b) for determining a position and/or a change in position of the monitoring device on the cooktop surface.
Non-medical use of a peptide or of its salt as a pesticide, said peptide having the sequence 1-octanoyl-Aib-X-Lys(HCl)-Leu-Y-Z wherein: X is chosen from the group consisting of: - Gly-Leu-Aib-Lys(HCl)-; - Gly-Leu-Aib-Gly-; and -Lys(HCl)-; or X is missing Y is the group: -Aib-Gly-Ile- or Y is missing and Z is chosen from the group consisting of: - Lol; and - Leu-NH 2, wherein said peptide is chosen from the group consisting of: 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:2), 1-octanoyl-Aib-Gly-Leu-Aib-Gly-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:4), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Lol (SEQ ID NO:5), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Leu-NH 2 (SEQ ID NO:6), or 1-octanoyl-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:7); and wherein said use as a pesticide is against plant and crop pathogenic oomycetes or fungi. X is chosen from the group consisting of: - Gly-Leu-Aib-Lys(HCl)-; - Gly-Leu-Aib-Gly-; and -Lys(HCl)-; - Gly-Leu-Aib-Lys(HCl)-; - Gly-Leu-Aib-Gly-; and -Lys(HCl)-; or X is missing Y is the group: -Aib-Gly-Ile- or Y is missing and Z is chosen from the group consisting of: - Lol; and - Leu-NH 2, - Lol; and - Leu-NH 2, wherein said peptide is chosen from the group consisting of: 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:2), 1-octanoyl-Aib-Gly-Leu-Aib-Gly-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:4), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Lol (SEQ ID NO:5), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Leu-NH 2 (SEQ ID NO:6), or 1-octanoyl-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:7); and 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:2), 1-octanoyl-Aib-Gly-Leu-Aib-Gly-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:4), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Lol (SEQ ID NO:5), 1-octanoyl-Aib-Gly-Leu-Aib-Lys(HCl)-Lys(HCl)-Leu-Leu-NH 2 (SEQ ID NO:6), or 1-octanoyl-Aib-Lys(HCl)-Lys(HCl)-Leu-Aib-Gly-Ile-Leu-NH 2 (SEQ ID NO:7); and wherein said use as a pesticide is against plant and crop pathogenic oomycetes or fungi.
A process for the preparation of a block copolymer comprising a first type of polyolefin block and at least one type of second polymer block, the process comprising the steps of: A) polymerizing at least one type of olefin monomer using a catalyst system to obtain a first polyolefin block containing a main group metal on at least one chain end; the catalyst system comprising: i) a metal catalyst or metal catalyst precursor comprising a metal from Group 3-10 of the IUPAC Periodic Table of elements; and ii) at least one type of chain transfer agent; and iii) optionally a co-catalyst; B) reacting the first polyolefin block containing a main group metal on at least one chain end obtained in step A) with at least one type of oxidizing agent and subsequently at least one type of metal substituting agent to obtain a first polyolefin block containing at least one functionalized chain end; C) forming at least one second polymer block on the first polyolefin block, wherein as an initiator the functionalized chain end of the first polyolefin block obtained in step B) is used to obtain the block copolymer, wherein step C) of obtaining a block copolymer is carried out by at least one nucleophilic substitution reaction at a carbonyl group-containing functionality of at least one type of second polymer. A) polymerizing at least one type of olefin monomer using a catalyst system to obtain a first polyolefin block containing a main group metal on at least one chain end; the catalyst system comprising: i) a metal catalyst or metal catalyst precursor comprising a metal from Group 3-10 of the IUPAC Periodic Table of elements; and ii) at least one type of chain transfer agent; and iii) optionally a co-catalyst; i) a metal catalyst or metal catalyst precursor comprising a metal from Group 3-10 of the IUPAC Periodic Table of elements; and ii) at least one type of chain transfer agent; and iii) optionally a co-catalyst; B) reacting the first polyolefin block containing a main group metal on at least one chain end obtained in step A) with at least one type of oxidizing agent and subsequently at least one type of metal substituting agent to obtain a first polyolefin block containing at least one functionalized chain end; C) forming at least one second polymer block on the first polyolefin block, wherein as an initiator the functionalized chain end of the first polyolefin block obtained in step B) is used to obtain the block copolymer, wherein step C) of obtaining a block copolymer is carried out by at least one nucleophilic substitution reaction at a carbonyl group-containing functionality of at least one type of second polymer.
A system comprising: a device configured for placement over at least a portion of a patient's eye socket to deliver light into the patient's eye, wherein the device comprises an eyepatch device configured to attach to the patient's head to cover at least a portion of the patient's eye, the device comprising: a printed circuit board comprising an array of light delivery devices to provide the light; a controller to power the printed circuit board; the system being characterised in that the device further comprises: a lens comprising a plurality of ridges that provide a heat sink for the light delivery devices; a flexible metallic ring to conform the printed circuit board and the lens to the patient's eye and to direct the light through the patient's eye and into the patient's pupil; and at least one Mylar sheet to facilitate a homogeneous uniform density of light the printed circuit board. a printed circuit board comprising an array of light delivery devices to provide the light; a controller to power the printed circuit board; the system being characterised in that the device further comprises: a lens comprising a plurality of ridges that provide a heat sink for the light delivery devices; a flexible metallic ring to conform the printed circuit board and the lens to the patient's eye and to direct the light through the patient's eye and into the patient's pupil; and at least one Mylar sheet to facilitate a homogeneous uniform density of light the printed circuit board. a lens comprising a plurality of ridges that provide a heat sink for the light delivery devices; a flexible metallic ring to conform the printed circuit board and the lens to the patient's eye and to direct the light through the patient's eye and into the patient's pupil; and at least one Mylar sheet to facilitate a homogeneous uniform density of light the printed circuit board.
A method for decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass which comprises heating the hemp extract or hemp biomass to a temperature of 40° C to 100° C in the presence of one or more divalent reagents, wherein the divalent reagent is selected from the group consisting of MgO, CaO, ZnO, Mg 2, Ca 2, CaCl 2, MgSO 4, MgSO 4 (H 2 O) 7, and ZnSO 4 and a mixture thereof.
A catheter-like device for the medical delivery and/or discharge of substances that are particularly odor-intensive, particularly soluble, or otherwise capable of migration, comprising - a balloon component (3, 3a) that anchors and retains a device that is placed in an organ or in a body interior space, - a delivering and/or discharging tube unit that adjoins the balloon component (3, 3a) and leads transluminally to the organ or to the interior space, and - an extracorporeally adjoining tube-like portion, characterized in that at least the extracorporeal tube-like portion is formed from a multilayer film, the multilayer film including at least one barrier layer made of an odor-proof barrier material and at least one carrier layer made of some other, mechanically stable material, the wall thickness of the carrier layer being greater than the wall thickness of the barrier layer, wherein one or more layers of the multilayer film material are coextruded with one another and wherein the (overall) thickness d T of the carrier layer or of all carrier layers is greater than or equal to five times the (overall) thickness d B of the barrier layer or of all barrier layers: d T ≥ 5 * d B. - a balloon component (3, 3a) that anchors and retains a device that is placed in an organ or in a body interior space, - a delivering and/or discharging tube unit that adjoins the balloon component (3, 3a) and leads transluminally to the organ or to the interior space, and - an extracorporeally adjoining tube-like portion,