A liquid chromatography filtration device (300, 400, 500), comprising: a housing (310, 410, 550, 560) having a fluidic inlet (312, 412, 512), a fluidic outlet (314, 414, 514), wherein the housing (310, 410, 550, 560) is configured to be connected in line with a fluidic flow path of a liquid chromatography system (600, 700) such that at least a portion of the fluidic flow path is located between the fluidic inlet (312, 412, 512) and the fluidic outlet(314, 414, 514); at least one filter (324, 424, 524), which can be disposed in the portion of the fluidic flow path; the at least one filter being made of a micromachined material or a sintered material; a filter element (318, 418, 518), wherein a plurality of filters, including the at least one filter (324, 424, 524), are disposed on the filter element (318, 418, 518); and a dynamic sealing mechanism configured such that: when the filter element (318, 418, 518) is in a first slidably engageable position there is a fluidic seal between the at least one filter (324, 424, 524) and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the at least one filter (324, 424, 524) on the filter element (318, 418, 518), and when the filter element (318, 418, 518) is in a second slidably engageable position there is a fluidic seal between another of the plurality of filters and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the another filter (324, 424, 524) on the filter element (318, 418, 518) and the portion of the fluidic flow path is isolated from the at least one filter (324, 424, 524) on both sides of the at least one filter (324, 424, 524). a housing (310, 410, 550, 560) having a fluidic inlet (312, 412, 512), a fluidic outlet (314, 414, 514), wherein the housing (310, 410, 550, 560) is configured to be connected in line with a fluidic flow path of a liquid chromatography system (600, 700) such that at least a portion of the fluidic flow path is located between the fluidic inlet (312, 412, 512) and the fluidic outlet(314, 414, 514); at least one filter (324, 424, 524), which can be disposed in the portion of the fluidic flow path; the at least one filter being made of a micromachined material or a sintered material; a filter element (318, 418, 518), wherein a plurality of filters, including the at least one filter (324, 424, 524), are disposed on the filter element (318, 418, 518); and a dynamic sealing mechanism configured such that: when the filter element (318, 418, 518) is in a first slidably engageable position there is a fluidic seal between the at least one filter (324, 424, 524) and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the at least one filter (324, 424, 524) on the filter element (318, 418, 518), and when the filter element (318, 418, 518) is in a second slidably engageable position there is a fluidic seal between another of the plurality of filters and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the another filter (324, 424, 524) on the filter element (318, 418, 518) and the portion of the fluidic flow path is isolated from the at least one filter (324, 424, 524) on both sides of the at least one filter (324, 424, 524). when the filter element (318, 418, 518) is in a first slidably engageable position there is a fluidic seal between the at least one filter (324, 424, 524) and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the at least one filter (324, 424, 524) on the filter element (318, 418, 518), and when the filter element (318, 418, 518) is in a second slidably engageable position there is a fluidic seal between another of the plurality of filters and the portion of the fluidic flow path such that fluid can flow from the fluidic inlet (312, 412, 512) to the fluidic outlet (314, 414, 514) through the another filter (324, 424, 524) on the filter element (318, 418, 518) and the portion of the fluidic flow path is isolated from the at least one filter (324, 424, 524) on both sides of the at least one filter (324, 424, 524).