A formulation for the controlled release of one or more active ingredients or one or more active ingredient containing cores in the colon of a mammal, which is adapted to release the one or more active ingredients or the one or more active ingredient containing cores depending on the course of the pH value, comprising a sequence of layers (layer sequence), which envelops the one or more active ingredients or the one or more active ingredient containing cores, wherein said layer sequence comprises a layer, which is soluble or permeable in aqueous solutions only above a defined pH value and, enveloped by said layer or arranged below it, comprises a layer, the solubility or permeability of which in aqueous solutions is dependent on the pH value, characterized in that it comprises one or more than one effectively parallel arranged layer sequences, which envelop the one or more active ingredients or the one or more active ingredient containing cores, wherein each layer sequence comprises an "inner" layer, which is soluble or permeable in aqueous solutions only above a defined last pH value, which also constitutes its defined upper pH value, which preferably lies between 2 and 9, more preferably between 4 and 8, and at least one layer sequence comprises, enveloped by or arranged below said "inner" layer, one or more "further" layers, which envelop or are arranged below each other, which each are soluble or permeable in aqueous solutions both below an individual defined lower pH value, which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, and above an individual defined upper pH value, which is higher than its own defined lower pH value, preferably by 0.1 to 2.5 pH levels, and which is higher than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, but not in between, and/or comprises, enveloped by or arranged below said "inner" layer or, in case the layer sequence comprises one or more "further" layers, enveloped by or arranged below said one or more "further" layers, a "most inner" layer, which is soluble or permeable in aqueous solutions only below a defined first pH value, which preferably lies between 2 and 9, more preferably between 3.8 and 8, and which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, wherein the formulation comprises at least one of the layers defined above as "further" layers, or at least two effectively parallel arranged layer sequences, wherein the effective parallel arrangement is ensured by the fact that in each case not the whole surface is covered so that the surface has at least one area per layer sequence, at which only that one has to become soluble or permeable in order for the intestinal content coming into contact with the one or more active ingredients or the one or more active ingredient containing cores and the one or more active ingredients can be released, wherein layers represent coatings or other types of envelopments. which is soluble or permeable in aqueous solutions only above a defined last pH value, which also constitutes its defined upper pH value, which preferably lies between 2 and 9, more preferably between 4 and 8, which each are soluble or permeable in aqueous solutions both below an individual defined lower pH value, which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, and above an individual defined upper pH value, which is higher than its own defined lower pH value, preferably by 0.1 to 2.5 pH levels, and which is higher than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, but not in between, and/or comprises, enveloped by or arranged below said "inner" layer or, in case the layer sequence comprises one or more "further" layers, enveloped by or arranged below said one or more "further" layers, a "most inner" layer, which is soluble or permeable in aqueous solutions only below a defined first pH value, which preferably lies between 2 and 9, more preferably between 3.8 and 8, and which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, both below an individual defined lower pH value, which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, and above an individual defined upper pH value, which is higher than its own defined lower pH value, preferably by 0.1 to 2.5 pH levels, and which is higher than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, which is higher than its own defined lower pH value, preferably by 0.1 to 2.5 pH levels, and which is higher than the defined upper pH value of the layer enveloping it or being arranged above it, preferably lower by 0.1 to 2.5 pH levels, but not in between, which is soluble or permeable in aqueous solutions only below a defined first pH value, which preferably lies between 2 and 9, more preferably between 3.8 and 8, and which is lower than the defined upper pH value of the layer enveloping it or being arranged above it, which preferably lies between 2 and 9, more preferably between 3.8 and 8, and which is lower than the defined upper pH value of the layer enveloping it or being arranged above it,