An artificial nephron device comprising a multi micro channel in which, while blood containing waste and water without other components are passing therethrough, the waste is separated so as to purify the blood and the separated waste is concentrated into the water to be discharged, wherein the multi micro channel comprises a glomerulus micro channel simulating a Glomerulus, a tubule micro channel simulating a Tubule, and a Henle's loop micro channel simulating a Henle's loop, further comprising: a blood purification passage including a blood inlet through which the blood is supplied, a blood outlet through which the blood purified while passing through the multi micro channel is discharged, and a blood passage which sequentially connects the blood inlet, the glomerulus micro channel, the tubule micro channel, the Henle's loop micro channel and the blood outlet; a water inlet (31, 32, 33) flowing water without other components into the glomerulus micro channel, the tubule micro channel and the Henle's loop micro channel; and a waste concentration passage including a waste outlet through which the waste having been concentrated into the water while passing through the multi micro channel is discharged, and a waste passage which sequentially connects the glomerulus micro channel, the tubule micro channel, the Henle's loop micro channel and the waste outlet, wherein the glomerulus micro channel separates small molecule from the blood and merges the same into the water and remains large molecule to the blood, the large molecule comprises hemoglobin, and the small molecule comprises glucose and urea, wherein the tubule micro channel separates the water containing the small molecule into the water containing the glucose and the water containing the urea, and wherein the Henle's loop micro channel regulates the amounts of water, according to the osmotic pressure, respectively in the water containing the glucose, the water containing the urea, and the water which is flowed thereinto separately from the water containing the glucose and the water containing the urea, and subsequently merges the water containing the glucose into the blood containing the remained hemoglobin to discharge as the purified blood, and discharges the water containing the urea as the water containing the waste. a blood purification passage including a blood inlet through which the blood is supplied, a blood outlet through which the blood purified while passing through the multi micro channel is discharged, and a blood passage which sequentially connects the blood inlet, the glomerulus micro channel, the tubule micro channel, the Henle's loop micro channel and the blood outlet; a water inlet (31, 32, 33) flowing water without other components into the glomerulus micro channel, the tubule micro channel and the Henle's loop micro channel; and a waste concentration passage including a waste outlet through which the waste having been concentrated into the water while passing through the multi micro channel is discharged, and a waste passage which sequentially connects the glomerulus micro channel, the tubule micro channel, the Henle's loop micro channel and the waste outlet, wherein the glomerulus micro channel separates small molecule from the blood and merges the same into the water and remains large molecule to the blood, the large molecule comprises hemoglobin, and the small molecule comprises glucose and urea, wherein the tubule micro channel separates the water containing the small molecule into the water containing the glucose and the water containing the urea, and wherein the Henle's loop micro channel regulates the amounts of water, according to the osmotic pressure, respectively in the water containing the glucose, the water containing the urea, and the water which is flowed thereinto separately from the water containing the glucose and the water containing the urea, and subsequently merges the water containing the glucose into the blood containing the remained hemoglobin to discharge as the purified blood, and discharges the water containing the urea as the water containing the waste.