A process for functionalizing a surface of a solid support with nano- or microparticles, said process comprising the stages of: i) Reacting at least one monomer with at least one amine, to obtain an amine-functionalized monomer, said at least one monomer being a mono, bi-, tri- or tetrafunctional monomer wherein said functions are chosen from acrylate, methacrylate, epoxy and vinyl groups, said vinyl groups not being acrylate or methacrylate groups, at least one of said functions being an acrylate, methacrylate or epoxy group, said at least one amine being chosen from: - amines of following formula NR 1 R 2 R 3, wherein R 1, R 2 and R 3 are each independently chosen from H and C 1 -C 8 linear or branched alkyl groups optionally substituted by a group R 4 chosen from -OH, -SH and aromatic groups, in particular phenyl, with the proviso that when R 1, R 2 and R 3 are not H, then at least one of R 1, R 2 and R 3 is a C 1 -C 8 linear or branched alkyl group substituted by at least one -OH or -SH group, in particular by at least one -OH group; - aminoacids, in particular α-amino acids, more particulary natural aminoacids; and - hexamethylenetetramine; ii) bringing at least said surface into contact with a composition consisting of or comprising: - the functionalized monomer obtained in step i); - a polymerization initiator; - a solvent; and optionally - a polymerization inhibitor; iii) polymerization of the composition of step ii) in contact with the surface to functionalize, to obtain a surface coated with an amine-functionalized polymer; and iv) contacting at least the surface coated with an amine-functionalized polymer obtained in step iii) with nano- or microparticles functionalized with negatively charged ligands, at a pH equal or less than (pKa of the amine, in particular of formula, + 1), to obtain a solid support with a surface functionalized with nano- or microparticles. i) Reacting at least one monomer with at least one amine, to obtain an amine-functionalized monomer, said at least one monomer being a mono, bi-, tri- or tetrafunctional monomer wherein said functions are chosen from acrylate, methacrylate, epoxy and vinyl groups, said vinyl groups not being acrylate or methacrylate groups, at least one of said functions being an acrylate, methacrylate or epoxy group, said at least one amine being chosen from: - amines of following formula NR 1 R 2 R 3, wherein R 1, R 2 and R 3 are each independently chosen from H and C 1 -C 8 linear or branched alkyl groups optionally substituted by a group R 4 chosen from -OH, -SH and aromatic groups, in particular phenyl, with the proviso that when R 1, R 2 and R 3 are not H, then at least one of R 1, R 2 and R 3 is a C 1 -C 8 linear or branched alkyl group substituted by at least one -OH or -SH group, in particular by at least one -OH group; - aminoacids, in particular α-amino acids, more particulary natural aminoacids; and - hexamethylenetetramine; said at least one monomer being a mono, bi-, tri- or tetrafunctional monomer wherein said functions are chosen from acrylate, methacrylate, epoxy and vinyl groups, said vinyl groups not being acrylate or methacrylate groups, at least one of said functions being an acrylate, methacrylate or epoxy group, said at least one amine being chosen from: - amines of following formula NR 1 R 2 R 3, wherein R 1, R 2 and R 3 are each independently chosen from H and C 1 -C 8 linear or branched alkyl groups optionally substituted by a group R 4 chosen from -OH, -SH and aromatic groups, in particular phenyl, with the proviso that when R 1, R 2 and R 3 are not H, then at least one of R 1, R 2 and R 3 is a C 1 -C 8 linear or branched alkyl group substituted by at least one -OH or -SH group, in particular by at least one -OH group; - aminoacids, in particular α-amino acids, more particulary natural aminoacids; and - hexamethylenetetramine; - amines of following formula NR 1 R 2 R 3, wherein R 1, R 2 and R 3 are each independently chosen from H and C 1 -C 8 linear or branched alkyl groups optionally substituted by a group R 4 chosen from -OH, -SH and aromatic groups, in particular phenyl, with the proviso that when R 1, R 2 and R 3 are not H, then at least one of R 1, R 2 and R 3 is a C 1 -C 8 linear or branched alkyl group substituted by at least one -OH or -SH group, in particular by at least one -OH group; - aminoacids, in particular α-amino acids, more particulary natural aminoacids; and - hexamethylenetetramine; ii) bringing at least said surface into contact with a composition consisting of or comprising: - the functionalized monomer obtained in step i); - a polymerization initiator; - a solvent; and optionally - a polymerization inhibitor; - the functionalized monomer obtained in step i); - a polymerization initiator; - a solvent; and optionally - a polymerization inhibitor; iii) polymerization of the composition of step ii) in contact with the surface to functionalize, to obtain a surface coated with an amine-functionalized polymer; and iv) contacting at least the surface coated with an amine-functionalized polymer obtained in step iii) with nano- or microparticles functionalized with negatively charged ligands, at a pH equal or less than (pKa of the amine, in particular of formula, + 1), to obtain a solid support with a surface functionalized with nano- or microparticles.