mhurhangee/ep-ind-claims huggingface dataset:
A recombinant adeno-associated virus having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional monospecific antibodies in a cell, wherein the recombinant AAV comprises: a 5' AAV inverted terminal repeat; a first expression cassette which encodes at least a first open reading frame for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF are for a second and third immunoglobulin construct; and a 3'AAV ITR, whereby an immunoglobulin light chain, a first immunoglobulin heavy chain and a second immunoglobulin heavy chain are encoded. a 5' AAV inverted terminal repeat; a first expression cassette which encodes at least a first open reading frame for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF are for a second and third immunoglobulin construct; and a 3'AAV ITR, whereby an immunoglobulin light chain, a first immunoglobulin heavy chain and a second immunoglobulin heavy chain are encoded.
A method of determining whether a pregnant subject has, or is predisposed to having, preeclampsia, the method comprising: a) measuring a level of sex hormone binding globulin (SHBG) in a biological sample obtained from a pregnant subject; b) measuring a level of placental growth factor (PIGF) in a biological sample obtained from the pregnant subject; c) comparing the SHBG level obtained from the pregnant subject with an SHBG level obtained from at least one subject having a normal pregnancy; and d) comparing the PIGF level obtained from the pregnant subject with a PIGF level obtained from at least one subject having a normal pregnancy, wherein low levels of SHBG and PIGF present in the sample obtained from the pregnant subject, as compared to the levels present in the at least one subject having a normal pregnancy, indicate that the pregnant subject has, or is predisposed to having, preeclampsia. a) measuring a level of sex hormone binding globulin (SHBG) in a biological sample obtained from a pregnant subject; b) measuring a level of placental growth factor (PIGF) in a biological sample obtained from the pregnant subject; c) comparing the SHBG level obtained from the pregnant subject with an SHBG level obtained from at least one subject having a normal pregnancy; and d) comparing the PIGF level obtained from the pregnant subject with a PIGF level obtained from at least one subject having a normal pregnancy,
A method of making an anhydrous, pigmented sunscreen composition, comprising in sequence: adding a hydrophobic silica to a lipid phase comprising a dispersed color pigment and an organic UV-filter; homogenizing the lipid phase comprising the hydrophobic silica by rotary mixing at a rotation speed of at least 1000 rpm; adding a hydrophilic silica to the lipid phase comprising hydrophobic silica; and re-homogenizing the lipid phase comprising the hydrophobic silica and the hydrophilic silica by rotary mixing at a rotation speed of at least 1000 rpm; wherein said lipid phase comprises one or more oils, and wherein said anhydrous, pigmented sunscreen composition comprises 40 % to 75 % by weight of oil. adding a hydrophobic silica to a lipid phase comprising a dispersed color pigment and an organic UV-filter; homogenizing the lipid phase comprising the hydrophobic silica by rotary mixing at a rotation speed of at least 1000 rpm; adding a hydrophilic silica to the lipid phase comprising hydrophobic silica; and re-homogenizing the lipid phase comprising the hydrophobic silica and the hydrophilic silica by rotary mixing at a rotation speed of at least 1000 rpm; wherein said lipid phase comprises one or more oils, and wherein said anhydrous, pigmented sunscreen composition comprises 40 % to 75 % by weight of oil.
A far-infrared imaging apparatus, comprising: a wavelength-tunable far-infrared light source for generating first far-infrared light; an illumination optical system for irradiating a line on a specimen with the first far-infrared light; a far-infrared light imaging optical system for forming an image of the specimen using second far-infrared light reflected from or transmitted through the specimen; an array sensor for detecting the image; a stage for placing the specimen, the stage being movable in at least one direction; a non-linear optical crystal for detection for converting the second far-infrared light from the specimen into near-infrared light by using pump light, wherein the non-linear optical crystal for detection is arranged in the vicinity of an image plane of the far-infrared light imaging optical system, and the end surface of the non-linear optical crystal for detection on which the pump light is incident is substantially parallel to the optical axis of the second far-infrared light in the non-linear optical crystal; and a detection optical system for directing the near-infrared light emitted from the non-linear optical crystal for detection onto the array sensor. a wavelength-tunable far-infrared light source for generating first far-infrared light; an illumination optical system for irradiating a line on a specimen with the first far-infrared light; a far-infrared light imaging optical system for forming an image of the specimen using second far-infrared light reflected from or transmitted through the specimen; an array sensor for detecting the image; a stage for placing the specimen, the stage being movable in at least one direction; a non-linear optical crystal for detection for converting the second far-infrared light from the specimen into near-infrared light by using pump light, wherein the non-linear optical crystal for detection is arranged in the vicinity of an image plane of the far-infrared light imaging optical system, and the end surface of the non-linear optical crystal for detection on which the pump light is incident is substantially parallel to the optical axis of the second far-infrared light in the non-linear optical crystal; and a detection optical system for directing the near-infrared light emitted from the non-linear optical crystal for detection onto the array sensor.
A method that includes one or more processing devices of a secure resource management system performing operations comprising: receiving a request to verify an authorized user of a resource; responsive to receiving the request, querying a resource record repository; determining, from a private blockchain, a resource user currently having a right to obtain the resource as the authorized user of the resource; transmitting, in response to the request, a verification result to a remote computing device (104, 110), the verification result identifying the authorized user of the resource, wherein the verification result is useable to grant access to the resource to the authorized user; characterised in that the resource record repository is implemented in a hybrid blockchain, the hybrid blockchain comprising (a) the private blockchain storing a resource record that comprises information of a resource provider of the resource, information of resource users having a right to obtain the resource, and a resource transaction history and (b) a public blockchain storing an encrypted version of the resource transaction history contained in the resource record, such that the public blockchain is usable to verify the authenticity of a transaction involving the resource, and wherein the public blockchain is directly accessible via a public data network and the private blockchain is only accessible by the secure resource management system. receiving a request to verify an authorized user of a resource; responsive to receiving the request, querying a resource record repository; determining, from a private blockchain, a resource user currently having a right to obtain the resource as the authorized user of the resource; transmitting, in response to the request, a verification result to a remote computing device (104, 110), the verification result identifying the authorized user of the resource, wherein the verification result is useable to grant access to the resource to the authorized user; characterised in that the resource record repository is implemented in a hybrid blockchain, the hybrid blockchain comprising (a) the private blockchain storing a resource record that comprises information of a resource provider of the resource, information of resource users having a right to obtain the resource, and a resource transaction history and (b) a public blockchain storing an encrypted version of the resource transaction history contained in the resource record, such that the public blockchain is usable to verify the authenticity of a transaction involving the resource, and wherein the public blockchain is directly accessible via a public data network and the private blockchain is only accessible by the secure resource management system.
A composition comprising nivolumab for use in treating a melanoma in a patient: (i) wherein the patient is identified as having a PD-L1 positive melanoma tumor by measuring a PD-L1 expression on the melanoma tumor; and (ii) wherein the patient is to be administered a flat dose of 480 mg of nivolumab as monotherapy once every four weeks, wherein the patient is not administered a combination of nivolumab and ipilimumab. (i) wherein the patient is identified as having a PD-L1 positive melanoma tumor by measuring a PD-L1 expression on the melanoma tumor; and (ii) wherein the patient is to be administered a flat dose of 480 mg of nivolumab as monotherapy once every four weeks, wherein the patient is not administered a combination of nivolumab and ipilimumab.
A method of configuring a storage system comprising a plurality of addressable panel controllers each having an indicator, the method comprising the steps of: broadcasting, by a system controller, an address set-up command to said panel controllers, said command including an address to be assigned; at each panel controller, after determining that a received command is a said address set-up command, displaying whether a valid address is set using the indicator; receiving a user selection at one of said plurality of panel controllers; and at the selected panel controller, determining whether said address to be assigned is from a preset range of addresses that are hard-coded in the panel controller; and if said address to be assigned is from the preset range of addresses that are hard-coded in the panel controller, storing said address to be assigned in the selected panel controller and displaying by the indicator that the address set-up was successful; and if said address to be assigned is not from the preset range of addresses that are hard-coded in the panel controller, rejecting said address. broadcasting, by a system controller, an address set-up command to said panel controllers, said command including an address to be assigned; at each panel controller, after determining that a received command is a said address set-up command, displaying whether a valid address is set using the indicator; receiving a user selection at one of said plurality of panel controllers; and at the selected panel controller, determining whether said address to be assigned is from a preset range of addresses that are hard-coded in the panel controller; and if said address to be assigned is from the preset range of addresses that are hard-coded in the panel controller, storing said address to be assigned in the selected panel controller and displaying by the indicator that the address set-up was successful; and if said address to be assigned is not from the preset range of addresses that are hard-coded in the panel controller, rejecting said address. if said address to be assigned is from the preset range of addresses that are hard-coded in the panel controller, storing said address to be assigned in the selected panel controller and displaying by the indicator that the address set-up was successful; and if said address to be assigned is not from the preset range of addresses that are hard-coded in the panel controller, rejecting said address.
A heat radiation structure (2, 2A, 2B) comprising: a heat spreader provided on a heating component mounted on a substrate; a heat sink (16, 16A) disposed at a position facing the heat spreader; a heat transfer member disposed between the heat spreader and the heat sink (16, 16A), and transmitting heat from the heat spreader to the heat sink (16; 16A) characterized by a conductive member (30, 30A, 30B) electrically connecting the heat spreader and the heat sink (16, 16A), distinct from said heat transfer member. a heat spreader provided on a heating component mounted on a substrate; a heat sink (16, 16A) disposed at a position facing the heat spreader; a heat transfer member disposed between the heat spreader and the heat sink (16, 16A), and transmitting heat from the heat spreader to the heat sink (16; 16A) characterized by a conductive member (30, 30A, 30B) electrically connecting the heat spreader and the heat sink (16, 16A), distinct from said heat transfer member.
A control valve arrangement of a fuel injector comprising a valve housing wherein are arranged a filling channel extending from a high pressure fuel supply line to a filling chamber, the filling chamber being in a first fluid communication with a first control chamber, wherein the first fluid communication is controlled by a filling valve normally biased open by a first spring, away from a first seat arranged in the valve housing, and a communication channel extending from the first control chamber to a second control chamber which is in a second fluid communication with a low pressure outlet line, wherein the filling valve comprises a stem, a guiding section of which is located within a guide portion of the valve housing; wherein the second fluid communication is controlled by a control valve normally biased in a closed position by a second spring, in complementary abutment against a second seat arranged in the housing, the control valve cooperating with an actuator to move from the normally closed position to an open position and, a bore in which a piston is slidably arranged, the piston piloting the injection of the fuel into a compression chamber; wherein the bore is in a third fluid communication with the first control chamber, and wherein the bore opens into the first control chamber such that the third fluid communication is unrestricted; wherein a fourth fluid communication is provided between the high pressure supply line and the second control chamber and, wherein the stem of the filling valve additionally comprises an elongate groove, and wherein a close clearance is maintained between the guiding section of the stem and the guide portion of the valve housing at regions either side of the groove, and wherein the fourth fluid communication comprises clearance between the groove and the guide portion of the valve housing and leak paths between the regions either side of the groove and the guide portion of the valve housing.
Drive for a sash/leaf of a window, of a door or the like, having a housing and having a piston which is arranged in the housing, interacts with an output shaft for opening and closing the sash/leaf, is loaded by a spring unit in the closing direction and by means of which the housing is subdivided into a spring space containing the spring unit and into a damping space, characterized in that the housing is filled with hydraulic liquid in such a way that a gas volume serving for pressure equalization is left in the spring space and hydraulic liquid can be transferred from the spring space into the damping space only through a sleeve connected to the piston and extending in the spring space or through a piston rod having at least one outflow duct, the cavity of which sleeve or respective outflow duct is in communication with the spring space via at least one inlet opening, and wherein the sleeve or piston rod is arranged in the spring space in such a way and a respective inlet opening is positioned in such a way that a respective inlet opening of the sleeve or piston rod is completely surrounded by the hydraulic liquid even at the lowest operating temperature of the drive.
Piezoelectric resonator at quartz having X, Y and Z crystalline axis and comprising a base and at least two vibrating arms (3, 3') connected to the base in a direction of a crystalline axis X, wherein the vibrating arms (3, 3') extend from the base in a direction of a crystalline axis +Y or -Y, wherein at least a first groove (4a, 4a') is formed on an upper face on a side +Z of each arm (3, 3') along the crystalline axis +Y or -Y on part of the length of the arms (3, 3') and wherein at least a second groove (4b, 4b') is formed on a lower face on a side -Z of each arm (3, 3') along said crystalline axis +Y or -Y on part of the length of the arms (3, 3') and opposite the first groove (4a, 4a'), where the first groove and the second groove are formed with different depths, characterized in that the depth of the first groove (4a, 4a') is less than 30% of the total thickness of each arm (3, 3') or more than 50% of the total thickness of each arm (3, 3'), and in that the depth of the second groove (4b, 4b') is more than 50% of the total thickness of each arm (3, 3') if the depth of the first groove (4a, 4a') is less than 30% of the total thickness of each arm (3, 3'), or less than 30% of the total thickness of each arm (3, 3') if the depth of the first groove (4a, 4a') is more than 50% of the total thickness of each arm (3, 3'), and in that the width of each groove (4a, 4a', 4b, 4b') is between 40% and 90% of the width of each arm (3, 3').
A non-toxic full-history time-temperature indicator system which exhibits a time-temperature dependent and visually detectable, substantially irreversible chemical reaction, the system comprising at least one immobilized and at least one mobile reactant, at least one of said immobilized and mobile reactants is a metal compound, said immobilized reactant being immobilized in a hydrocolloid gel, said reactants being contained in separate adjacent compartments, and said at least one immobilized and at least one mobile reactant initially being separated by a sealing to prevent contact between the reactants.
Stacking panel, formed from at least three board layers, formed in each case by parallel boards, a plurality of dowel nodes which consist of two or more dowels arranged so as to be inclined with respect to one another being provided for connecting the board layers, which result in a connection of board layers stacked one above the other such that the individual board layers are inseparably interconnected because the dowels are pressed two-dimensionally into the board layers, characterised in that each of the dowels of the plurality of dowel nodes interconnects only two board layers, a plurality of dowel nodes being arranged one above the other in each case, an overlap of the individual dowels being prevented by the inclined arrangement of the dowels, and the superimposed dowels being arranged preferably in parallel.
A liquid laundry composition comprising: (i) one or more anionic surfactants; and (ii) a non-ionic ethoxylated C 10 Guerbet alcohol surfactant with a degree of ethoxylation in the range of 1 to 10; wherein the total amount of anionic surfactant in the composition is in the range of 3 to 16 wt% of the total composition and the weight ratio of the total amount of anionic surfactant to the non-ionic ethoxylated C 10 Guerbet alcohol surfactant is in the range of 8:1 to 60:1. (i) one or more anionic surfactants; and (ii) a non-ionic ethoxylated C 10 Guerbet alcohol surfactant with a degree of ethoxylation in the range of 1 to 10;
Use of a filter material in a foodstuff packaging having a fiber product (2, 2.1, 2.2, 2.3) that is interspersed with the filter material for binding of mineral oil substances for reducing the migration of mineral oil substances from the fiber product (2, 2.1, 2.2, 2.3) into another product to a migration value of at least less than 0.6 mg/kg, wherein the fiber product is card, board and/or paper.
An in-vehicle gateway for relaying communication data in an in-vehicle network including a time-triggered network, the in-vehicle gateway comprising: a transmission unit that transmits communication data to the in-vehicle network; a reception unit that receives communication data from the in-vehicle network; a network configuration changing unit that changes a slot amount used by the in-vehicle gateway for the time-triggered network, or a slot ID used by the in-vehicle gateway for the time-triggered network, in accordance with a traffic to be relayed by the in-vehicle gateway; a process timing determination unit that synchronizes the timing of execution of a process allocated to a slot for the time-triggered network with the slot; and a relay processing unit that relays the communication data by the transmission unit, characterized in that after the slot amount or the slot ID is changed by the network configuration changing unit, the process timing determination unit readjusts the timing of execution of the process, so that the transmission unit can complete a necessary preprocessing for transmitting the communication data by a slot time of the time-triggered network assigned to the transmission unit for transmission of the communication data. a transmission unit that transmits communication data to the in-vehicle network; a reception unit that receives communication data from the in-vehicle network; a network configuration changing unit that changes a slot amount used by the in-vehicle gateway for the time-triggered network, or a slot ID used by the in-vehicle gateway for the time-triggered network, in accordance with a traffic to be relayed by the in-vehicle gateway; a process timing determination unit that synchronizes the timing of execution of a process allocated to a slot for the time-triggered network with the slot; and a relay processing unit that relays the communication data by the transmission unit, characterized in that after the slot amount or the slot ID is changed by the network configuration changing unit, the process timing determination unit readjusts the timing of execution of the process, so that the transmission unit can complete a necessary preprocessing for transmitting the communication data by a slot time of the time-triggered network assigned to the transmission unit for transmission of the communication data.
A method comprising: beamforming a plurality of microphone outputs to obtain at least one virtual microphone channel; performing voice recognition on the at least one virtual microphone channel; and characterised by: adjusting a corresponding beamform until the voice recognition indicates that voice is not present on the at least one virtual microphone channel. beamforming a plurality of microphone outputs to obtain at least one virtual microphone channel; performing voice recognition on the at least one virtual microphone channel; and characterised by: adjusting a corresponding beamform until the voice recognition indicates that voice is not present on the at least one virtual microphone channel.