A multiple layer interlayer comprising: a first polymer layer comprising a first poly(vinyl acetal) resin; a second polymer layer comprising a second poly(vinyl acetal) resin; a third polymer layer comprising a third poly(vinyl acetal) resin; a fourth polymer layer comprising a fourth poly(vinyl acetal) resin; and a fifth polymer layer comprising a fifth poly(vinyl acetal) resin, wherein said second polymer layer is disposed between and in contact with each of said first and said third polymer layers and wherein said fourth polymer layer is disposed between and in contact with each of said third and said fifth polymer layers, wherein each of said second and said fourth polymer layers has a glass transition temperature that is at least 3°C different than the glass transition temperature of at least one of said first, third, and fifth polymer layers, the glass transition temperature being determined by mechanical thermal analysis as a function of temperature at an oscillation frequency of 1 Hz under shear mode and temperature sweep rate of 3°C/ min by determining the position of the tan delta peak on the temperature scale, and wherein each of said second and said fourth polymer layers has a thickness of less than 50 microns, wherein each of said first, second, third, fourth, and fifth poly(vinyl acetal) resins has a respective first, second, third, fourth, and fifth residual hydroxyl content and a respective first, second, third, fourth, and fifth residual acetate content, and wherein at least one of the following statements is true - (i) the difference between at least one of the first, third, and fifth residual hydroxyl contents and at least one of the second and the fourth residual hydroxyl contents is at least 2 weight percent; and (ii) the difference between at least one of the first, third, and fifth residual acetate contents and at least one of the second and the fourth residual acetate contents is at least 2 weight percent and (iii) wherein the maximum difference between one of the first, third, and fifth residual acetate contents and one of the second and the fourth residual acetate contents is not more than 4 weight percent, the residual hydroxyl and acetate contents being measured according to ASTM D-1396. a first polymer layer comprising a first poly(vinyl acetal) resin; a second polymer layer comprising a second poly(vinyl acetal) resin; a third polymer layer comprising a third poly(vinyl acetal) resin; a fourth polymer layer comprising a fourth poly(vinyl acetal) resin; and a fifth polymer layer comprising a fifth poly(vinyl acetal) resin, wherein said second polymer layer is disposed between and in contact with each of said first and said third polymer layers and wherein said fourth polymer layer is disposed between and in contact with each of said third and said fifth polymer layers, wherein each of said second and said fourth polymer layers has a glass transition temperature that is at least 3°C different than the glass transition temperature of at least one of said first, third, and fifth polymer layers, the glass transition temperature being determined by mechanical thermal analysis as a function of temperature at an oscillation frequency of 1 Hz under shear mode and temperature sweep rate of 3°C/ min by determining the position of the tan delta peak on the temperature scale, and wherein each of said second and said fourth polymer layers has a thickness of less than 50 microns, wherein each of said first, second, third, fourth, and fifth poly(vinyl acetal) resins has a respective first, second, third, fourth, and fifth residual hydroxyl content and a respective first, second, third, fourth, and fifth residual acetate content, and wherein at least one of the following statements is true - (i) the difference between at least one of the first, third, and fifth residual hydroxyl contents and at least one of the second and the fourth residual hydroxyl contents is at least 2 weight percent; and (ii) the difference between at least one of the first, third, and fifth residual acetate contents and at least one of the second and the fourth residual acetate contents is at least 2 weight percent and (iii) wherein the maximum difference between one of the first, third, and fifth residual acetate contents and one of the second and the fourth residual acetate contents is not more than 4 weight percent, (i) the difference between at least one of the first, third, and fifth residual hydroxyl contents and at least one of the second and the fourth residual hydroxyl contents is at least 2 weight percent; and (ii) the difference between at least one of the first, third, and fifth residual acetate contents and at least one of the second and the fourth residual acetate contents is at least 2 weight percent and (iii) wherein the maximum difference between one of the first, third, and fifth residual acetate contents and one of the second and the fourth residual acetate contents is not more than 4 weight percent, the residual hydroxyl and acetate contents being measured according to ASTM D-1396.