A compound of Formula 1, a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer, wherein: R 1 is selected from hydrogen, halo, -CN, C 1-4 alkyl, C 1-4 haloalkyl, and -OR 14; R 2 and R 3 together with carbon atoms to which they are attached, form a benzene ring or a pyridine ring, each optionally substituted with one or two substituents independently selected from fluoro, chloro, and methyl; R 4 has the formula in which indicates a point of attachment; L is selected from -O-, -CH 2 O-, and -N(R 4e)-; R 4a is selected from -CH 2 R 5 and ethenyl optionally substituted with from one to three methyl substituents; and (a) R 4c is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4d, together with a nitrogen atom and carbon atoms to which R 4b, R 4c, and R 4d are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (b) R 4b is selected from hydrogen and C 1-4 alkyl, R 4d is hydrogen, L is -N(R 4e)-, and R 4c and R 4e, together with the carbon atoms and a nitrogen atom to which R 4c, R 4d, and R 4e are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (c) R 4d is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4c, together with the nitrogen and carbon atoms to which R 4b and R 4c are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; R 5 is selected from hydrogen, halo, and C 1-4 alkyl; and R 14 is independently selected from hydrogen, C 1-4 alkyl, and C 1-4 haloalkyl. R 1 is selected from hydrogen, halo, -CN, C 1-4 alkyl, C 1-4 haloalkyl, and -OR 14; R 2 and R 3 together with carbon atoms to which they are attached, form a benzene ring or a pyridine ring, each optionally substituted with one or two substituents independently selected from fluoro, chloro, and methyl; R 4 has the formula in which indicates a point of attachment; L is selected from -O-, -CH 2 O-, and -N(R 4e)-; R 4a is selected from -CH 2 R 5 and ethenyl optionally substituted with from one to three methyl substituents; and (a) R 4c is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4d, together with a nitrogen atom and carbon atoms to which R 4b, R 4c, and R 4d are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (b) R 4b is selected from hydrogen and C 1-4 alkyl, R 4d is hydrogen, L is -N(R 4e)-, and R 4c and R 4e, together with the carbon atoms and a nitrogen atom to which R 4c, R 4d, and R 4e are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (c) R 4d is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4c, together with the nitrogen and carbon atoms to which R 4b and R 4c are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; L is selected from -O-, -CH 2 O-, and -N(R 4e)-; R 4a is selected from -CH 2 R 5 and ethenyl optionally substituted with from one to three methyl substituents; and (a) R 4c is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4d, together with a nitrogen atom and carbon atoms to which R 4b, R 4c, and R 4d are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (b) R 4b is selected from hydrogen and C 1-4 alkyl, R 4d is hydrogen, L is -N(R 4e)-, and R 4c and R 4e, together with the carbon atoms and a nitrogen atom to which R 4c, R 4d, and R 4e are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (c) R 4d is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4c, together with the nitrogen and carbon atoms to which R 4b and R 4c are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; (a) R 4c is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4d, together with a nitrogen atom and carbon atoms to which R 4b, R 4c, and R 4d are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (b) R 4b is selected from hydrogen and C 1-4 alkyl, R 4d is hydrogen, L is -N(R 4e)-, and R 4c and R 4e, together with the carbon atoms and a nitrogen atom to which R 4c, R 4d, and R 4e are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; or (c) R 4d is hydrogen, R 4e is selected from hydrogen and C 1-4 alkyl when L is -N(R 4e)-, and R 4b and R 4c, together with the nitrogen and carbon atoms to which R 4b and R 4c are respectively attached, form an unsubstituted pyrrolidine ring or an unsubstituted piperidine ring; R 5 is selected from hydrogen, halo, and C 1-4 alkyl; and R 14 is independently selected from hydrogen, C 1-4 alkyl, and C 1-4 haloalkyl.