A continuous fermentation, separation, and refinement apparatus of products comprising: a culture bath in which a microbe is cultured together with a raw material to produce the products; at least two columns (110,120) filled with an adsorbent; and a conversion part (170,172,174,176) configured to control a flow of a culture medium containing the products, so that a culture medium containing the products is supplied from the culture bath to a specific column (110,120), wherein the conversion part (170,172,174,176) is configured to change into where the culture medium flows from a first column to a second column in the case in which the products are sufficiently adsorbed in the first column supplied with the culture medium, wherein a continuous flow of culture medium from the culture bath is maintained, wherein the case in which the products are sufficiently adsorbed is a case in which an adsorption rate of the product with respect to the adsorbent is decreased, a case in which a concentration of the product in the discharge solution discharged from the column (110,120) is 80% or more of a concentration of the product in the culture medium supplied to the column (110,120), a case in which growth of the microbe in the culture bath is inhibited by an increase in the concentration of the product, or a case in which productivity of the product of the microbe is decreased, or a case in which the concentration of butanol in the culture medium reaches at about 12 g/L, and wherein the first column and second column (110,120) each include a stirrer stirring the adsorbent and the product in the column and a filter preventing the adsorbent from being eluted to thereby be lost. a culture bath in which a microbe is cultured together with a raw material to produce the products; at least two columns (110,120) filled with an adsorbent; and a conversion part (170,172,174,176) configured to control a flow of a culture medium containing the products, so that a culture medium containing the products is supplied from the culture bath to a specific column (110,120), wherein the conversion part (170,172,174,176) is configured to change into where the culture medium flows from a first column to a second column in the case in which the products are sufficiently adsorbed in the first column supplied with the culture medium, wherein a continuous flow of culture medium from the culture bath is maintained, wherein the case in which the products are sufficiently adsorbed is a case in which an adsorption rate of the product with respect to the adsorbent is decreased, a case in which a concentration of the product in the discharge solution discharged from the column (110,120) is 80% or more of a concentration of the product in the culture medium supplied to the column (110,120), a case in which growth of the microbe in the culture bath is inhibited by an increase in the concentration of the product, or a case in which productivity of the product of the microbe is decreased, or a case in which the concentration of butanol in the culture medium reaches at about 12 g/L, and wherein the first column and second column (110,120) each include a stirrer stirring the adsorbent and the product in the column and a filter preventing the adsorbent from being eluted to thereby be lost.