A method of generating an oxygenated compound from an aqueous feedstock solution comprising water and at least one water soluble oxygenated hydrocarbon having two or more carbon atoms and selected from ethanediol, ethanedione, acetic acid, propanol, propanediol, propionic acid, glycerol, glyceraldehyde, dihydroxyacetone, lactic acid, pyruvic acid, malonic acid, butanediols, butanoic acid, aldotetroses, tautaric acid, aldopentoses, aldohexoses, ketotetroses, ketopentoses, ketohexoses, alditols, sugars, sugar alcohols, cellulosics, lignocellulosics, saccharides, starches and polyols, the method comprising the steps of: a) generating aqueous phase reforming hydrogen by contacting an oxygenated hydrocarbon in a first portion of the aqueous feedstock solution with a first catalytic material comprising at least one Group VIII metal at: i. a temperature of 80°C to 400°C; ii. a weight hourly space velocity of at least 1.0 gram of the oxygenated hydrocarbon per gram of the first catalytic material per hour; and iii. a pressure where the water and the oxygenated hydrocarbons are condensed liquids; and b) reacting the APR hydrogen with an oxygenated hydrocarbon in a second portion of the feedstock solution to reduce the oxygenated hydrocarbon over a second catalytic material, the second catalytic material being different than the first catalytic material and being selected from the group consisting of: iron, ruthenium, copper, rhenium, cobalt, nickel, alloys thereof, and mixtures thereof, at: i. a temperature of 100°C to 300°C; and ii. a pressure of 1480 kPa to 8375 kPa (200 psig to 1200 psig), to produce a reaction product comprising at least one reduced oxygenated hydrocarbon compound selected from the group consisting of a polyol, a ketone, an aldehyde, a carboxylic acid and an alcohol. a) generating aqueous phase reforming hydrogen by contacting an oxygenated hydrocarbon in a first portion of the aqueous feedstock solution with a first catalytic material comprising at least one Group VIII metal at: i. a temperature of 80°C to 400°C; ii. a weight hourly space velocity of at least 1.0 gram of the oxygenated hydrocarbon per gram of the first catalytic material per hour; and iii. a pressure where the water and the oxygenated hydrocarbons are condensed liquids; and i. a temperature of 80°C to 400°C; ii. a weight hourly space velocity of at least 1.0 gram of the oxygenated hydrocarbon per gram of the first catalytic material per hour; and iii. a pressure where the water and the oxygenated hydrocarbons are condensed liquids; and b) reacting the APR hydrogen with an oxygenated hydrocarbon in a second portion of the feedstock solution to reduce the oxygenated hydrocarbon over a second catalytic material, the second catalytic material being different than the first catalytic material and being selected from the group consisting of: iron, ruthenium, copper, rhenium, cobalt, nickel, alloys thereof, and mixtures thereof, at: i. a temperature of 100°C to 300°C; and ii. a pressure of 1480 kPa to 8375 kPa (200 psig to 1200 psig), to produce a reaction product comprising at least one reduced oxygenated hydrocarbon compound selected from the group consisting of a polyol, a ketone, an aldehyde, a carboxylic acid and an alcohol. i. a temperature of 100°C to 300°C; and ii. a pressure of 1480 kPa to 8375 kPa (200 psig to 1200 psig),