mhurhangee/ep-ind-claims huggingface dataset:
A vesicle comprising a membrane containing: a block copolymer having an uncharged hydrophilic segment and a cationic segment; and a nucleic acid; said membrane defining a cavity surrounded thereby, wherein the uncharged hydrophilic segment is polyalkylene glycol and the cationic segment is polyamine, and wherein the molecular weight ratio X of the uncharged hydrophilic segment is within the range of 0.05 < X < 0.1, said weight ratio X being defined as follows: X = M N M N + M C + M A * P C N + / P * P A wherein: M N represents the molecular weight of the uncharged hydrophilic segment, M C represents the molecular weight of the cationic segment, M A represents the molecular weight of the nucleic acid, P C represents the number of cationic amino groups in the cationic segment, P A represents the number of the phosphate groups in the nucleic acid, and N + /P is the mole ratio of cationic groups of the cationic segment to phosphate groups of the nucleic acid and is within the range of 1.0 < N + /P < 3.0. a block copolymer having an uncharged hydrophilic segment and a cationic segment; and a nucleic acid; said membrane defining a cavity surrounded thereby, wherein the uncharged hydrophilic segment is polyalkylene glycol and the cationic segment is polyamine, and wherein the molecular weight ratio X of the uncharged hydrophilic segment is within the range of 0.05 < X < 0.1, said weight ratio X being defined as follows: X = M N M N + M C + M A * P C N + / P * P A wherein: M N represents the molecular weight of the uncharged hydrophilic segment, M C represents the molecular weight of the cationic segment, M A represents the molecular weight of the nucleic acid, P C represents the number of cationic amino groups in the cationic segment, P A represents the number of the phosphate groups in the nucleic acid, and N + /P is the mole ratio of cationic groups of the cationic segment to phosphate groups of the nucleic acid and is within the range of 1.0 < N + /P < 3.0. M N represents the molecular weight of the uncharged hydrophilic segment, M C represents the molecular weight of the cationic segment, M A represents the molecular weight of the nucleic acid, P C represents the number of cationic amino groups in the cationic segment, P A represents the number of the phosphate groups in the nucleic acid, and N + /P is the mole ratio of cationic groups of the cationic segment to phosphate groups of the nucleic acid and is within the range of 1.0 < N + /P < 3.0.
A system, comprising: an aircraft recorder (110, 120) configured to be installed on an aircraft; and a plurality of memory units (130, 140, 150, 160) configured to be installed on the aircraft and remotely located from the aircraft recorder (110, 120), wherein the memory units (130, 140, 150, 160) are configured to receive streaming audio and flight data from the aircraft recorder, characterized in that, the plurality of the memory units are connected to the aircraft recorder by an Ethernet network comprising at least one of a copper network or a fiber network, wherein the plurality of memory units (130, 140, 150, 160) are powered by power from the aircraft recorder (110, 120). an aircraft recorder (110, 120) configured to be installed on an aircraft; and a plurality of memory units (130, 140, 150, 160) configured to be installed on the aircraft and remotely located from the aircraft recorder (110, 120), wherein the memory units (130, 140, 150, 160) are configured to receive streaming audio and flight data from the aircraft recorder, characterized in that, the plurality of the memory units are connected to the aircraft recorder by an Ethernet network comprising at least one of a copper network or a fiber network, wherein the plurality of memory units (130, 140, 150, 160) are powered by power from the aircraft recorder (110, 120).
Surface cleaning device for cleaning a surface, the surface cleaning device comprising: a brush having a rotation axis at a center of a cross-section of the brush, the rotation axis being substantially parallel to the surface, characterized in that the brush is curved at least partially around a center part of the surface cleaning device, the rotation axis being curved at least partially around the center part of the surface cleaning device, a deformability of the brush determining a deformability of an outer circumference of the surface cleaning device. a brush having a rotation axis at a center of a cross-section of the brush, the rotation axis being substantially parallel to the surface, the brush is curved at least partially around a center part of the surface cleaning device, the rotation axis being curved at least partially around the center part of the surface cleaning device, a deformability of the brush determining a deformability of an outer circumference of the surface cleaning device.
A method of determining whether a composition is capable of causing coeliac disease comprising determining whether a protein with a sequence that is capable of being modified by a transglutaminase to a sequence selected from: (i) transglutaminase-deamidated SEQ ID NOs: 1787, 1793, 1794, 1796 and 1797; is present in the composition, the presence of the protein indicating that the composition is capable of causing coeliac disease. (i) transglutaminase-deamidated SEQ ID NOs: 1787, 1793, 1794, 1796 and 1797;
An apparatus comprising: a plurality of radio ports (A, B, C, D) for interconnection with radio circuits, a plurality of antenna ports (A', B', C', D') for interconnection with antennas, interconnection circuitry configured to enable interconnection of each of one or more radio ports to different non-overlapping sets of the antenna ports, said interconnection circuitry comprises a cascade arrangement of selection circuits, each selection circuit comprising two first ports and two second ports, said cascade arrangement comprising a first tier comprising a single selection circuit that has a second port interconnected to a first one of the first ports of a first selection circuit in a second, lower order tier and a different, second port interconnected to a first one of the first ports of a second selection circuit in the second, lower order tier, wherein two of the radio ports (A, C) are interconnected to the first ports of the selection circuit in the first tier, a third radio port is interconnected to a second of the first ports of a first one of the selection circuits 60 in the second tier and a fourth radio port is interconnected to a second one of the first ports of the second selection circuit in the second tier, the second ports of the first selection circuit in the second tier and the second ports of the second selection circuit 60 in the second tier are interconnected to the plurality of antenna ports, (A', B', C', D'). a plurality of radio ports (A, B, C, D) for interconnection with radio circuits, a plurality of antenna ports (A', B', C', D') for interconnection with antennas, interconnection circuitry configured to enable interconnection of each of one or more radio ports to different non-overlapping sets of the antenna ports, said interconnection circuitry comprises a cascade arrangement of selection circuits, each selection circuit comprising two first ports and two second ports, said cascade arrangement comprising a first tier comprising a single selection circuit that has a second port interconnected to a first one of the first ports of a first selection circuit in a second, lower order tier and a different, second port interconnected to a first one of the first ports of a second selection circuit in the second, lower order tier, wherein two of the radio ports (A, C) are interconnected to the first ports of the selection circuit in the first tier, a third radio port is interconnected to a second of the first ports of a first one of the selection circuits 60 in the second tier and a fourth radio port is interconnected to a second one of the first ports of the second selection circuit in the second tier, the second ports of the first selection circuit in the second tier and the second ports of the second selection circuit 60 in the second tier are interconnected to the plurality of antenna ports, (A', B', C', D').
An anti-transthyretin humanized antibody or fragment thereof, said antibody and fragment having the activity to inhibit fibrillization of TTR, wherein said humanized antibody and fragment thereof comprise the complementarity determining regions of an H chain consisting of the polypeptide of (a) below and the complementarity determining regions of an L chain consisting of the polypeptide of (b) below: (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NOs: 1 to 3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NOs: 4 to 6. (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NOs: 1 to 3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NOs: 4 to 6.
A tool (170,300) for measuring a geological formation surrounding a wellbore (104,220), the tool comprising: a tool body; one or more sensor pads (202,302), each sensor pad being coupled to the tool body by an extendable coupling (206,306), each coupling being operable to adjust the radial position of the sensor pad by extending away from or retracting toward the tool body; one or more sensors (204,304), each sensor being mounted to one of the sensor pads and operable to obtain a measurement a property of the formation; a downhole control unit (172,310) having a transmitter and receiver, the downhole control unit being operable to receive the measurement and transmit the measurement to a surface controller, wherein the transmitted measurement indicates a measurement resolution, characterized in that the downhole control unit is further operable to receive a control signal from the surface controller (184,320) based on the measurement resolution, and to extend or retract the sensor pad in response to the control signal. a tool body; one or more sensor pads (202,302), each sensor pad being coupled to the tool body by an extendable coupling (206,306), each coupling being operable to adjust the radial position of the sensor pad by extending away from or retracting toward the tool body; one or more sensors (204,304), each sensor being mounted to one of the sensor pads and operable to obtain a measurement a property of the formation; a downhole control unit (172,310) having a transmitter and receiver, the downhole control unit being operable to receive the measurement and transmit the measurement to a surface controller, wherein the transmitted measurement indicates a measurement resolution, characterized in that the downhole control unit is further operable to receive a control signal from the surface controller (184,320) based on the measurement resolution, and to extend or retract the sensor pad in response to the control signal.
A method for producing a mesh including a resin mesh main body, and a resin reinforcing member configured to reinforce the mesh main body, the method comprising: a step of forming a plurality of through-holes using a laser beam in a mesh formation region of a first film material made of resin; a step of forming an opening portion in a second film material made of resin; a step of layering the first film material and the second film material so that the mesh formation region and the opening portion are arranged at positions that conform to each other; and a step of joining the first film material and the second film material to each other through laser welding at a portion surrounding the opening portion. a step of forming a plurality of through-holes using a laser beam in a mesh formation region of a first film material made of resin; a step of forming an opening portion in a second film material made of resin; a step of layering the first film material and the second film material so that the mesh formation region and the opening portion are arranged at positions that conform to each other; and a step of joining the first film material and the second film material to each other through laser welding at a portion surrounding the opening portion.
Method for characterizing in vitro the ageing of an epithelium comprising at least the steps consisting in: a) determining in a sample of the said epithelium the content of polypeptide having an amino acid sequence encoded by a nucleic acid sequence represented as a whole by a sequence represented by SEQ ID NO 1, in particular represented as a whole by a sequence represented by SEQ ID NO 2, or a nucleic acid sequence encoding the said polypeptide, and b) comparing the said content determined in step a) to a reference value. a) determining in a sample of the said epithelium the content of polypeptide having an amino acid sequence encoded by a nucleic acid sequence represented as a whole by a sequence represented by SEQ ID NO 1, in particular represented as a whole by a sequence represented by SEQ ID NO 2, or a nucleic acid sequence encoding the said polypeptide, and b) comparing the said content determined in step a) to a reference value.
A knot carrier for indirectly coupling a knot to a medical device, the knot carrier comprising: a knot carrier body, configured to slidably engage with a portion of a medical device; and an obstructing member projecting from a proximal portion of the knot carrier body, the obstructing member having a first configuration for preventing a knot from being deployed from the knot carrier and a second configuration for allowing the knot to be deployed from the knot carrier. a knot carrier body, configured to slidably engage with a portion of a medical device; and an obstructing member projecting from a proximal portion of the knot carrier body, the obstructing member having a first configuration for preventing a knot from being deployed from the knot carrier and a second configuration for allowing the knot to be deployed from the knot carrier.
A method of charging an inker in a lithographic printing press including a plurality of printing units, each printing unit including a blanket cylinder, a plate cylinder, a take away roller, and an ink train, comprising: placing all of the printing units of the printing press in an off impression position, with a continuous substrate passing through the printing units, each printing unit including a blanket cylinder; in one or more printing units of the plurality of printing units, moving the takeaway roller into contact with the blanket cylinder of the printing unit; and thereafter driving the ink train, plate cylinder, blanket cylinder and the take away roller at a first surface speed, whereby the ink from the ink train is transmitted to the plate cylinder from the ink train, from the plate cylinder to the blanket cylinder, and from the blanket cylinder to the take away roller; and during said driving step, keeping the continuous substrate stationary or moving the continuous substrate at a second surface speed less than 50% of the first surface speed. placing all of the printing units of the printing press in an off impression position, with a continuous substrate passing through the printing units, each printing unit including a blanket cylinder; in one or more printing units of the plurality of printing units, moving the takeaway roller into contact with the blanket cylinder of the printing unit; and thereafter driving the ink train, plate cylinder, blanket cylinder and the take away roller at a first surface speed, whereby the ink from the ink train is transmitted to the plate cylinder from the ink train, from the plate cylinder to the blanket cylinder, and from the blanket cylinder to the take away roller; and during said driving step, keeping the continuous substrate stationary or moving the continuous substrate at a second surface speed less than 50% of the first surface speed.
A cartridge casing comprising: a single walled casing tube having a first end provided with a corner edge; a head cap provided with a shoulder edge, wherein the first end of the casing tube abuts and is joined with the head cap such that the corner edge of the casing tube sits within the shoulder edge of the head cap; and such that an orifice in the first end of the casing tube is aligned with a passage in the head cap to define a flash passage; and the head cap and casing tube are held together by a deformable member which directly clamps against the end cap and casing tube to thereby provide a mechanical joint between the head cap and casing tube; wherein: the deformable member, tube casing and head cap comprise a ferritic alloy; an environmental seal material is provided between the first end of the casing tube and head cap; and the walls of the casing tube are configured to contain a pressure of up to about 500MPa. a single walled casing tube having a first end provided with a corner edge; a head cap provided with a shoulder edge, wherein the first end of the casing tube abuts and is joined with the head cap such that the corner edge of the casing tube sits within the shoulder edge of the head cap; and such that an orifice in the first end of the casing tube is aligned with a passage in the head cap to define a flash passage; and the head cap and casing tube are held together by a deformable member which directly clamps against the end cap and casing tube to thereby provide a mechanical joint between the head cap and casing tube; wherein: the deformable member, tube casing and head cap comprise a ferritic alloy; an environmental seal material is provided between the first end of the casing tube and head cap; and the walls of the casing tube are configured to contain a pressure of up to about 500MPa. the deformable member, tube casing and head cap comprise a ferritic alloy; an environmental seal material is provided between the first end of the casing tube and head cap; and the walls of the casing tube are configured to contain a pressure of up to about 500MPa.
A manual breast pump (20, 100, 120) comprising: a body having a communicating part that communicates with space surrounded by a hood placed on a breast when in use; a diaphragm that deforms to generate a negative pressure in the communicating part; and a handle for operation that approaches and separates from the body to deform the diaphragm, the handle having a lift part that is arranged above the diaphragm to lift and thereby deform the diaphragm and further having a lever part that turns from the lift part and extends adjacent a side surface of the body, the lever part approaching the body when the lift part lifts and thereby deforms the diaphragm in order to generate the negative pressure; and characterized by a colliding part (40, 50, 82), against which the handle collides before the lever part of the handle and the body directly contact each other when the lever part approaches the body, is provided in at least a region of the body or the diaphragm, the colliding part (40, 50, 82) is integrally made of a same material as a material of the region in which the colliding part (40, 50, 82) is arranged, and the colliding part (40, 50, 82) has a damper structure that absorbs an impulsive force generated when making the collision or reduces propagation of the impulsive force; wherein the handle collides against the colliding part (40, 50, 82) when the lever part of the handle approaches the body in order to generate the negative pressure. a body having a communicating part that communicates with space surrounded by a hood placed on a breast when in use; a diaphragm that deforms to generate a negative pressure in the communicating part; and a handle for operation that approaches and separates from the body to deform the diaphragm, the handle having a lift part that is arranged above the diaphragm to lift and thereby deform the diaphragm and further having a lever part that turns from the lift part and extends adjacent a side surface of the body, the lever part approaching the body when the lift part lifts and thereby deforms the diaphragm in order to generate the negative pressure; and characterized by a colliding part (40, 50, 82), against which the handle collides before the lever part of the handle and the body directly contact each other when the lever part approaches the body, is provided in at least a region of the body or the diaphragm, the colliding part (40, 50, 82) is integrally made of a same material as a material of the region in which the colliding part (40, 50, 82) is arranged, and the colliding part (40, 50, 82) has a damper structure that absorbs an impulsive force generated when making the collision or reduces propagation of the impulsive force; wherein the handle collides against the colliding part (40, 50, 82) when the lever part of the handle approaches the body in order to generate the negative pressure.
A fuel pump comprising; a pump head (112; 212) defining a barrel in which a pumping plunger (116; 216) is slidable to pressurise fuel in a pumping chamber (122; 222), and a fluid-inlet path (120; 220) through which fuel flows in to the pumping chamber (122; 222) under control of an inlet valve during a plunger return stroke, wherein the pumping plunger (116; 216) is configured to cause pressurisation of the fuel in the fluid-inlet path (120; 220) and, wherein a portion of the fluid-inlet path (120; 220) is defined by a priming-pump chamber (123; 223), said fluid-inlet path (120; 220) comprising a fluid-inlet passage (120b; 220b) defined through the pump head (112; 212) and leading from the priming-pump chamber (123; 223) to a pumping-chamber inlet (125; 225) and, wherein said fluid-inlet passage (120b; 220b) is configured to permit fuel to flow into the priming-pump chamber (123; 223) from a fluid-inlet gallery.
A method of manufacturing a toothbrush with needle-shaped bristles, comprising: setting needle-shaped bristles, partially tapered by being immersed in a chemical such that end points of the bristles range from 0.03 to 0.05mm in thickness and tapered portions of the bristles range from 3.5 to 10mm in length, in a head part of a toothbrush body; and grinding the needle-shape bristles using a drum grinder having protrusions such that end points of the bristles, range from 0.01 to 0.03mm in thickness and tapered portions of the bristles range from 3.5 to 8mm in length, characterized in that the drum grinder is coupled to a rotor, the drum grinder rotates in a longitudinal direction while the rotor simultaneously rotates in a transverse direction and the protrusions range from 2 to 10mm in height.
A gas turbine engine comprising: a main compressor section having a high pressure compressor with a downstream discharge, and more upstream locations, wherein a main fan delivers bypass air into a bypass duct and into said main compressor section; a turbine section having a high pressure turbine; and a tap tapping air from at least one of said more upstream locations in said compressor section, passing said tapped air through a heat exchanger and then to a cooling compressor, said cooling compressor compressing air downstream of said heat exchanger, characterized in that: said tap is further configured to deliver air into said high pressure turbine, and in that said turbine section drives a tower shaft, said tower shaft further driving an impeller of said cooling compressor. a main compressor section having a high pressure compressor with a downstream discharge, and more upstream locations, wherein a main fan delivers bypass air into a bypass duct and into said main compressor section; a turbine section having a high pressure turbine; and a tap tapping air from at least one of said more upstream locations in said compressor section, passing said tapped air through a heat exchanger and then to a cooling compressor, said cooling compressor compressing air downstream of said heat exchanger, characterized in that: said tap is further configured to deliver air into said high pressure turbine, and in that said turbine section drives a tower shaft, said tower shaft further driving an impeller of said cooling compressor.