Process for producing a saposin lipoprotein particle, wherein the produced saposin lipoprotein particle comprises - a saposin-like protein, - lipids, and - optionally, a hydrophobic agent, wherein the hydrophobic agent is different from the lipids and wherein the process comprises the following steps: a) providing the lipids, and optionally the hydrophobic agent; b.1) contacting the saposin-like protein with a support that is capable of selectively binding the saposin-like protein to the support in a liquid environment; c.1) contacting the support-bound saposin-like protein with the lipids and, optionally, the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle; or wherein alternatively the process comprises the following steps: a) providing the hydrophobic agent and the lipids; b.2) contacting the hydrophobic agent with a support that is capable of selectively binding the hydrophobic agent to the support; c.2) contacting the support-bound hydrophobic agent with the saposin-like protein to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle. - a saposin-like protein, - lipids, and - optionally, a hydrophobic agent, wherein the hydrophobic agent is different from the lipids and wherein the process comprises the following steps: a) providing the lipids, and optionally the hydrophobic agent; b.1) contacting the saposin-like protein with a support that is capable of selectively binding the saposin-like protein to the support in a liquid environment; c.1) contacting the support-bound saposin-like protein with the lipids and, optionally, the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle; or wherein alternatively the process comprises the following steps: a) providing the hydrophobic agent and the lipids; b.2) contacting the hydrophobic agent with a support that is capable of selectively binding the hydrophobic agent to the support; c.2) contacting the support-bound hydrophobic agent with the saposin-like protein to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle. wherein the process comprises the following steps: a) providing the lipids, and optionally the hydrophobic agent; b.1) contacting the saposin-like protein with a support that is capable of selectively binding the saposin-like protein to the support in a liquid environment; c.1) contacting the support-bound saposin-like protein with the lipids and, optionally, the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle; or a) providing the lipids, and optionally the hydrophobic agent; b.1) contacting the saposin-like protein with a support that is capable of selectively binding the saposin-like protein to the support in a liquid environment; c.1) contacting the support-bound saposin-like protein with the lipids and, optionally, the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle; or b.1) contacting the saposin-like protein with a support that is capable of selectively binding the saposin-like protein to the support in a liquid environment; c.1) contacting the support-bound saposin-like protein with the lipids and, optionally, the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle; or wherein alternatively the process comprises the following steps: a) providing the hydrophobic agent and the lipids; b.2) contacting the hydrophobic agent with a support that is capable of selectively binding the hydrophobic agent to the support; c.2) contacting the support-bound hydrophobic agent with the saposin-like protein to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle. a) providing the hydrophobic agent and the lipids; b.2) contacting the hydrophobic agent with a support that is capable of selectively binding the hydrophobic agent to the support; c.2) contacting the support-bound hydrophobic agent with the saposin-like protein to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle. b.2) contacting the hydrophobic agent with a support that is capable of selectively binding the hydrophobic agent to the support; c.2) contacting the support-bound hydrophobic agent with the saposin-like protein to allow for the self-assembly of the saposin lipoprotein particle on the support; d) optionally eluting the support-bound saposin lipoprotein particle.