An 1,3,4-oxadiazole sulfamide derivative compound represented by the following formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof: wherein L 1, L 2 or L 3 are each independently a bond or -(C 1 -C 2 alkylene)-; Z 1 to Z 4 are each independently N or CR Z, wherein R Z is -H or -X; R 1 is -CX 2 H or -CX 3; R 2 is or -NR 8 R 9, wherein Y is -N-, -O- or -S(=O) 2 -, a to d are each independently an integer of 1, 2 or 3, Ra to Rd are each independently -H or -(C 1 -C 4 alkyl), the dotted line is a single bond or a double bond, R 4 and R 5 are each independently -H, -X, -(C 1 -C 4 alkyl), -aryl or -NReRf, provided that the dotted line is a double bond, R 5 is null, Re and Rf are each independently -H or -(C 1 -C 4 alkyl), when Y is -N-, R 6 and R 7 are each independently -H, -(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl),-C(=O)-O(C 1 -C 4 alkyl), -C(=O)-CF 3, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloaklyl), -aryl, -(C 1 -C 4 alkyl)-aryl, -heteroaryl or amine protecting group, wherein at least one H of the -(C 1 -C 4 alkyl) may be substituted with -X or -OH, at least one H of the -aryl, -(C 1 -C 4 alkyl)-aryl or -heteroaryl may be substituted with -X, -OH or -CF 3, and the -(C 2 -C 6 heterocycloalkyl) may contain an N, O or S atom in the ring, and when Y is -O- or -S(=O) 2 -, R 6 and R 7 are null, R 8 and R 9 are each independently -H, -(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl), -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl), -aryl, -heteroaryl or -(C 1 -C 4 alkyl)-aryl, wherein at least one H of the -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl), -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl), -aryl, -heteroaryl or -(C 1 -C 4 alkyl)-aryl may be substituted with -(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl) or -(C 2 -C 6 heterocycloalkyl); and R 3 is -H, -(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl)-O(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl) -C(=O)-O(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -aryl,-heteroaryl or wherein at least one H of the -(C 3 -C 7 cycloalkyl), -aryl or -heteroaryl may be substituted with -X, -OH, -(C 1 -C 4 alkyl), -CF 3, -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl) -(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl),-C(=O)-O(C 1 -C 4 alkyl), -O(C 1 -C 4 alkyl), -OCF 3, -S(=O) 2 -(C 1 -C 4 alkyl), -aryl, -heteroaryl or -NR 11 R 12, R 11 and R 12 are each independently -H or -(C 1 -C 4 alkyl), R 1, L 1, Z 1, Z 2, Z 3 and Z 4 are as defined above; and X is F, Cl, Br or I. wherein L 1, L 2 or L 3 are each independently a bond or -(C 1 -C 2 alkylene)-; Z 1 to Z 4 are each independently N or CR Z, wherein R Z is -H or -X; R 1 is -CX 2 H or -CX 3; R 2 is or -NR 8 R 9, wherein Y is -N-, -O- or -S(=O) 2 -, a to d are each independently an integer of 1, 2 or 3, Ra to Rd are each independently -H or -(C 1 -C 4 alkyl), the dotted line is a single bond or a double bond, R 4 and R 5 are each independently -H, -X, -(C 1 -C 4 alkyl), -aryl or -NReRf, provided that the dotted line is a double bond, R 5 is null, Re and Rf are each independently -H or -(C 1 -C 4 alkyl), when Y is -N-, R 6 and R 7 are each independently -H, -(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl),-C(=O)-O(C 1 -C 4 alkyl), -C(=O)-CF 3, -(C 1 -C 4 alkyl)-C(=O)-O(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloaklyl), -aryl, -(C 1 -C 4 alkyl)-aryl, -heteroaryl or amine protecting group, wherein at least one H of the -(C 1 -C 4 alkyl) may be substituted with -X or -OH, at least one H of the -aryl, -(C 1 -C 4 alkyl)-aryl or -heteroaryl may be substituted with -X, -OH or -CF 3, and the -(C 2 -C 6 heterocycloalkyl) may contain an N, O or S atom in the ring, and when Y is -O- or -S(=O) 2 -, R 6 and R 7 are null, R 8 and R 9 are each independently -H, -(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl), -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl), -aryl, -heteroaryl or -(C 1 -C 4 alkyl)-aryl, wherein at least one H of the -(C 3 -C 7 cycloalkyl), -(C 2 -C 6 heterocycloalkyl), -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl), -aryl, -heteroaryl or -(C 1 -C 4 alkyl)-aryl may be substituted with -(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl), -S(=O) 2 -(C 1 -C 4 alkyl) or -(C 2 -C 6 heterocycloalkyl); and R 3 is -H, -(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl)-O(C 1 -C 4 alkyl), -(C 1 -C 4 alkyl) -C(=O)-O(C 1 -C 4 alkyl), -(C 3 -C 7 cycloalkyl), -aryl,-heteroaryl or wherein at least one H of the -(C 3 -C 7 cycloalkyl), -aryl or -heteroaryl may be substituted with -X, -OH, -(C 1 -C 4 alkyl), -CF 3, -(C 1 -C 4 alkyl)-(C 2 -C 6 heterocycloalkyl) -(C 1 -C 4 alkyl), -C(=O)-(C 1 -C 4 alkyl),-C(=O)-O(C 1 -C 4 alkyl), -O(C 1 -C 4 alkyl), -OCF 3, -S(=O) 2 -(C 1 -C 4 alkyl), -aryl, -heteroaryl or -NR 11 R 12, R 11 and R 12 are each independently -H or -(C 1 -C 4 alkyl), R 1, L 1, Z 1, Z 2, Z 3 and Z 4 are as defined above; and X is F, Cl, Br or I.