A system for reducing neural activity of nerves around a blood vessel of a patient, the system comprising: a handle; an inner catheter (110, 110', 110", 110′′′) comprising a guidewire lumen extending through at least a portion of a length of the inner catheter; a proximal region of the inner catheter operatively coupled to the handle; a transducer assembly comprising a transducer shaft having an ultrasound transducer (114, 114', 114", 114'", 114"", 1900, 1910, 1950) coupled thereto, the ultrasound transducer configured to be actuated to emit ultrasonic energy within the blood vessel to reduce neural activity of nerves around the blood vessel, the transducer shaft comprising a lumen sized and shaped to slidably receive the inner catheter therein and a proximal region operatively coupled to the handle; an outer catheter (116, 116', 116", 116′′′) comprising a lumen sized and shaped to receive the transducer shaft therein and a proximal region operatively coupled to the handle; an expandable anchor (200, 200', 200", 200′′′, 200"", 2200, 2220, 2500, 2600, 3000) comprising a distal end coupled to the inner catheter and a proximal end coupled to the outer catheter such that relative movement between the inner catheter and the outer catheter causes the expandable anchor to transition between a collapsed delivery state and an expanded deployed state, the expandable anchor configured to centralize the ultrasound transducer within the blood vessel of the patient in the expanded deployed state; a sheath (118, 118', 118") comprising a lumen sized and shaped to slidably receive the outer catheter and the expandable anchor in the collapsed delivery state therein, a distal region (118b, 118b') of the sheath having a stiffness sufficient to facilitate transitioning of the expandable anchor from the expanded deployed state to the collapsed delivery state upon movement of the distal region of the sheath relative to the expandable anchor without buckling the distal region of the sheath, a proximal region of the sheath operatively coupled to the handle; a separation sleeve comprising a lumen sized and shaped to slidably receive the sheath therein, a proximal region of the separation sleeve fixedly coupled to the handle; an introducer configured to be fixed relative to the patient, the introducer comprising a lumen sized and shaped to slidably receive the sheath and the separation sleeve therein; and a valve disposed within the lumen of the introducer, the valve configured to be actuated against the separation sleeve when the separation sleeve is disposed within the lumen of the introducer to prevent relative movement between the separation sleeve and the introducer such that the sheath is moveable relative to the separation sleeve without relative movement between the transducer assembly and the patient. a handle; an inner catheter (110, 110', 110", 110′′′) comprising a guidewire lumen extending through at least a portion of a length of the inner catheter; a proximal region of the inner catheter operatively coupled to the handle; a transducer assembly comprising a transducer shaft having an ultrasound transducer (114, 114', 114", 114'", 114"", 1900, 1910, 1950) coupled thereto, the ultrasound transducer configured to be actuated to emit ultrasonic energy within the blood vessel to reduce neural activity of nerves around the blood vessel, the transducer shaft comprising a lumen sized and shaped to slidably receive the inner catheter therein and a proximal region operatively coupled to the handle; an outer catheter (116, 116', 116", 116′′′) comprising a lumen sized and shaped to receive the transducer shaft therein and a proximal region operatively coupled to the handle; an expandable anchor (200, 200', 200", 200′′′, 200"", 2200, 2220, 2500, 2600, 3000) comprising a distal end coupled to the inner catheter and a proximal end coupled to the outer catheter such that relative movement between the inner catheter and the outer catheter causes the expandable anchor to transition between a collapsed delivery state and an expanded deployed state, the expandable anchor configured to centralize the ultrasound transducer within the blood vessel of the patient in the expanded deployed state; a sheath (118, 118', 118") comprising a lumen sized and shaped to slidably receive the outer catheter and the expandable anchor in the collapsed delivery state therein, a distal region (118b, 118b') of the sheath having a stiffness sufficient to facilitate transitioning of the expandable anchor from the expanded deployed state to the collapsed delivery state upon movement of the distal region of the sheath relative to the expandable anchor without buckling the distal region of the sheath, a proximal region of the sheath operatively coupled to the handle; a separation sleeve comprising a lumen sized and shaped to slidably receive the sheath therein, a proximal region of the separation sleeve fixedly coupled to the handle; an introducer configured to be fixed relative to the patient, the introducer comprising a lumen sized and shaped to slidably receive the sheath and the separation sleeve therein; and a valve disposed within the lumen of the introducer, the valve configured to be actuated against the separation sleeve when the separation sleeve is disposed within the lumen of the introducer to prevent relative movement between the separation sleeve and the introducer such that the sheath is moveable relative to the separation sleeve without relative movement between the transducer assembly and the patient.