A compound having the structure: wherein L 1, L 2 and-N(SO 2 R 12)- together with the attached carbons of the aromatic ring to form a 5-12 member ring, containing 1-4 heteroatoms of N, O, S, P and/or Si; L 1 or L 2 is independently selected from the group consisting of a bond, -O-, -C(R 15 R 16)-, -NR 3 -,-S n,-, -P -, -Si(R 4 R 5)-, -C -, -C O-, and substituted alkyl, alkenyl, alkoxy, cycloalkyl, cycloalkoxy, heterocycle, aryl, heteroaryl, amide, carbamate, urea, and sulfonamide; n is 0, 1, or 2; and R 1 is selected from hydrogen, halide, -CF 3, -CN, -C H, -C OR 6 -, -C NHR 7,-C N R 7, -C(=NOMe)NHR 7, C(=NOH)NHR 7, -C(CF 3)NHR 8, -C NHR 9,-S 2 NHR 10, -C(=NCN)NHR 11, R 2 is a phenyl having one or more R 17 substituents; R 3 is selected from the group of hydrogen, alkylcarbonyl, cycloalkylcarbonyl, alkoxylcarbonyl, cycloalkoxycarbonyl, alkylsulfonyl and cycloalkylsulfonyl; R 4 and R 5 are independently methyl, ethyl, or cyclopropyl; R 6 is hydrogen, allyl, C 1-4 alkyl, cyclopropyl, or benzyl; R 7 is hydrogen, C 1-4 alkyl, cyclopropyl, C 1-4 alkoxy, cyclopropoxy, alkylsulfonyl, or cycloalkyl sulfonyl; R 8, R 9, R 10, or R 11 is independently hydrogen, C 1-4 alkyls, cyclopropyl, C 1-4 alkoxys, or cyclopropoxy; and R 12 is independently C 1-3 alkyl, cyclopropyl, -OMe, or -NHMe; R 15, R 16 is independently hydrogen, hydroxyl, azide, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkyl, cyclopropyl, C 1-4 alkoxy, or cyclopropoxy or R 15 and R 16 together are a carbonyl or C 1-4 alkenylidene or R 15 and R 16 joined together with the attached carbon are 3-6 member ring optionally containing 0-3 heteroatoms of O, NR N and/or S; each R N is independently selected from the group consisting of hydrogen, -OH, C 1 to C 12 alkyl, C 1 to C 12 heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate and sulfonamide; two R N may be taken together with C, O, N or S to which they are attached to form a five to seven membered ring which may optionally contain a further heteroatom; and R 17 is F, Cl or CN; or a pharmaceutically acceptable salt thereof L 1, L 2 and-N(SO 2 R 12)- together with the attached carbons of the aromatic ring to form a 5-12 member ring, containing 1-4 heteroatoms of N, O, S, P and/or Si; L 1 or L 2 is independently selected from the group consisting of a bond, -O-, -C(R 15 R 16)-, -NR 3 -,-S n,-, -P -, -Si(R 4 R 5)-, -C -, -C O-, and substituted alkyl, alkenyl, alkoxy, cycloalkyl, cycloalkoxy, heterocycle, aryl, heteroaryl, amide, carbamate, urea, and sulfonamide; n is 0, 1, or 2; and R 1 is selected from hydrogen, halide, -CF 3, -CN, -C H, -C OR 6 -, -C NHR 7,-C N R 7, -C(=NOMe)NHR 7, C(=NOH)NHR 7, -C(CF 3)NHR 8, -C NHR 9,-S 2 NHR 10, -C(=NCN)NHR 11, R 2 is a phenyl having one or more R 17 substituents; R 3 is selected from the group of hydrogen, alkylcarbonyl, cycloalkylcarbonyl, alkoxylcarbonyl, cycloalkoxycarbonyl, alkylsulfonyl and cycloalkylsulfonyl; R 4 and R 5 are independently methyl, ethyl, or cyclopropyl; R 6 is hydrogen, allyl, C 1-4 alkyl, cyclopropyl, or benzyl; R 7 is hydrogen, C 1-4 alkyl, cyclopropyl, C 1-4 alkoxy, cyclopropoxy, alkylsulfonyl, or cycloalkyl sulfonyl; R 8, R 9, R 10, or R 11 is independently hydrogen, C 1-4 alkyls, cyclopropyl, C 1-4 alkoxys, or cyclopropoxy; and R 12 is independently C 1-3 alkyl, cyclopropyl, -OMe, or -NHMe; R 15, R 16 is independently hydrogen, hydroxyl, azide, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkyl, cyclopropyl, C 1-4 alkoxy, or cyclopropoxy or R 15 and R 16 together are a carbonyl or C 1-4 alkenylidene or R 15 and R 16 joined together with the attached carbon are 3-6 member ring optionally containing 0-3 heteroatoms of O, NR N and/or S; each R N is independently selected from the group consisting of hydrogen, -OH, C 1 to C 12 alkyl, C 1 to C 12 heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate and sulfonamide; two R N may be taken together with C, O, N or S to which they are attached to form a five to seven membered ring which may optionally contain a further heteroatom; and R 17 is F, Cl or CN;