A microsurgical tool (510a; 510b; 530; 610; 710a; 710b; 730; 810; 910; 1010; 1110; 1420; 1440; 1520; 1610; 1650; 1710; 1815; 1830; 2010; 2050; 2310) for monitoring electrophysiological activity within the vicinity of an organ within a body, the microsurgical tool comprising: an endoscopically deliverable elongate structure configured so as to extend from an entry site within the body to the vicinity of the organ; and at least one sensing tip (140; 145; 155; 535; 620; 715; 830; 940; 1017; 1235; 1240; 1535; 1620; 1645; 2030; 2055; 2060; 2215a-d) electrically and mechanically coupled to the endoscopically deliverable elongate structure, the at least one sensing tip being configured: to interface with tissues in the vicinity of the organ; to measure local neural activity associated with the tissues in the vicinity of the organ; and to convey one or more electrophysiological signals associated with the local neural activity; wherein the at least one sensing tip comprises a clamp structure (110a; 110b) having an inner surface configured contact the tissues in the vicinity of the organ and an outer surface opposite the inner surface; and wherein the at least one sensing tip comprises: a plurality of electrodes (140; 145) arranged on the inner surface of the clamp, the plurality of electrodes comprising one or more sensing electrodes configured to measure the local neural activity associated with the tissues in the vicinity of the organ; and one or more additional electrodes arranged on the outer surface of the clamp, the one or more additional electrodes arranged on the outer surface of the clamp being configured to determine a reference signal used by the at least one sensing tip to cancel out ambient environmental action potentials and noise from measurements of the local neural activity by the one or more sensing electrodes on the inner surface of the clamp; and wherein the clamp structure comprises a self-wrapping tool. an endoscopically deliverable elongate structure configured so as to extend from an entry site within the body to the vicinity of the organ; and at least one sensing tip (140; 145; 155; 535; 620; 715; 830; 940; 1017; 1235; 1240; 1535; 1620; 1645; 2030; 2055; 2060; 2215a-d) electrically and mechanically coupled to the endoscopically deliverable elongate structure, the at least one sensing tip being configured: to interface with tissues in the vicinity of the organ; to measure local neural activity associated with the tissues in the vicinity of the organ; and to convey one or more electrophysiological signals associated with the local neural activity; to interface with tissues in the vicinity of the organ; to measure local neural activity associated with the tissues in the vicinity of the organ; and to convey one or more electrophysiological signals associated with the local neural activity; wherein the at least one sensing tip comprises a clamp structure (110a; 110b) having an inner surface configured contact the tissues in the vicinity of the organ and an outer surface opposite the inner surface; and wherein the at least one sensing tip comprises: a plurality of electrodes (140; 145) arranged on the inner surface of the clamp, the plurality of electrodes comprising one or more sensing electrodes configured to measure the local neural activity associated with the tissues in the vicinity of the organ; and one or more additional electrodes arranged on the outer surface of the clamp, the one or more additional electrodes arranged on the outer surface of the clamp being configured to determine a reference signal used by the at least one sensing tip to cancel out ambient environmental action potentials and noise from measurements of the local neural activity by the one or more sensing electrodes on the inner surface of the clamp; and a plurality of electrodes (140; 145) arranged on the inner surface of the clamp, the plurality of electrodes comprising one or more sensing electrodes configured to measure the local neural activity associated with the tissues in the vicinity of the organ; and one or more additional electrodes arranged on the outer surface of the clamp, the one or more additional electrodes arranged on the outer surface of the clamp being configured to determine a reference signal used by the at least one sensing tip to cancel out ambient environmental action potentials and noise from measurements of the local neural activity by the one or more sensing electrodes on the inner surface of the clamp; and wherein the clamp structure comprises a self-wrapping tool.