An orthopedic system comprising: a lateral wedge positionable under a foot of a user, the lateral wedge including: posterior and anterior ends (116, 118); upper and lower surfaces (102, 104) extending between the posterior and anterior ends (116, 118); a first side extending between the upper and lower surfaces (102, 104); a second side opposed the first side; a thickness defined between the upper and lower surfaces (102, 104), wherein the thickness tapers from the first side toward the second side such that the lateral wedge provides a lift under the foot to unload pressure from an affected compartment of the knee by supporting a lateral side of the foot or a medial side of the foot in an elevated position relative to the other, at least one trim line extending in a direction between the posterior and anterior ends (116, 118), the lateral wedge being trimmable along the at least one trim line to vary or control the amount of lift provided under the foot by varying the thickness of the lateral wedge along the first side relative to the thickness of the lateral wedge along the second side, the upper surface extending at a downward angle (β) relative to a horizontal surface parallel to the lower surface and from the first side to the second side, characterized in further comprising a concave-shaped cutout defined in the anterior end and configured to terminate short of phalanges of the foot, and a ramped surface extending diagonally across the upper surface between the first and second sides in a forefoot region of the lateral wedge and angling downwardly from the upper surface to the concave-shaped cutout, the ramped surface configured to help roll a user's foot over along a given line of progression when the user steps forward on the lateral wedge. posterior and anterior ends (116, 118); upper and lower surfaces (102, 104) extending between the posterior and anterior ends (116, 118); a first side extending between the upper and lower surfaces (102, 104); a second side opposed the first side; a thickness defined between the upper and lower surfaces (102, 104), wherein the thickness tapers from the first side toward the second side such that the lateral wedge provides a lift under the foot to unload pressure from an affected compartment of the knee by supporting a lateral side of the foot or a medial side of the foot in an elevated position relative to the other, at least one trim line extending in a direction between the posterior and anterior ends (116, 118), the lateral wedge being trimmable along the at least one trim line to vary or control the amount of lift provided under the foot by varying the thickness of the lateral wedge along the first side relative to the thickness of the lateral wedge along the second side, the upper surface extending at a downward angle (β) relative to a horizontal surface parallel to the lower surface and from the first side to the second side, characterized in further comprising a concave-shaped cutout defined in the anterior end and configured to terminate short of phalanges of the foot, and a ramped surface extending diagonally across the upper surface between the first and second sides in a forefoot region of the lateral wedge and angling downwardly from the upper surface to the concave-shaped cutout, the ramped surface configured to help roll a user's foot over along a given line of progression when the user steps forward on the lateral wedge.