A compound of formula, wherein A and A' are independently from each other -CH 2 - or -CH 2 -CH 2 -; R is selected from -N R 1 R 2, -N R 3 R 4 R 5 (+) Z 1 (-) and -OR 13; X denotes halogen; Z 1 (-) denotes halogen anion or an organic acid anion; Z 2 (-) denotes halogen anion or an organic acid anion; Z 3 (-) denotes halogen anion or an organic acid anion; Z 4 (-) denotes halogen anion or an organic acid anion; R 1 and R 2 are selected independently from each other from H, -C(NH 2)NH, -CN(CH 3) 2 N(CH 3) 2 + Z 2 -, -C 1-3 -alkyl, -C 2-4 -alkyl-N(CH 3) 2, -C 1-3 -alkyl-phenyl- R 12, -C 1-3 -alkyl-COOH, -C 1-4 -alkyl-CO- Y 2 - R 11, -CO-phenyl-CO-O- R 13, -CO-C 1-4 -alkyl, -CO-C 1-3 -alkyl-N R 6 R 7, -CO-C 1-3 -alkyl-N(CH 3) 3 + Z 3 -, -CO-C 1-4 -alkyl- Y 1 - R 9, -CO-O-C 1-4 -alkyl- R 8, -CO-NH-C 3-7 -cycloalkyl, -CO-NH-C 1-4 -alkyl, -CH 2 -CO-O-C 1-3 -alkyl, -CH 2 -CO-O-C 1-3 -alkyl-phenyl and -SO 2 - R 10; R 6 is selected from -C 1-3 -alkyl, H, -C 1-4 -alkyl-OH, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 7 is selected from -C 1-3 -alkyl, -CO-O-C 1-3 -alkyl, -C 1-4 -alkyl-OH, H, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 8 denotes H or phenyl; R 9 is selected from H, -C 1-3 -alkyl, OH, -N R 6 R 7 and =O; R 10 is C 1-3 -alkyl or an optionally substituted N-containing nonaromatic heterocycle; R 11 is selected from H, C 1-3 -alkyl, =O, -N(CH 3) 2 and -N(CH 3) 3 + Z 4 -; R 12 is selected from H, halogen, -COOH, -PO(OC 1-4 -alkyl)OH optionally substituted at the 2,3 or 4 position of the C 1-4 -alkyl group by -N(C 1-3 -alkyl) 2 or -N(C 1-3 -alkyl) 3 + Z 4 -, and -PO(OC 1-4 -alkyl) 2, -PO 2; R 13 is selected from H or C 1-4 -alkyl; Y 1 is selected from an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle, -N(C 1-3 -alkyl)-C 2-4 -alkyl-N(C 1-3 -alkyl) 2 and -N(C 1-3 -alkyl)-C 2-4 -alkyl-N + (C 1-3 alkyl) 3 Z 1 (-); Y 2 is an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle; or R 1 and R 2 are together with the nitrogen atom they are attached to an optionally substituted 4-7-membered heterocycle, containing at least one N and optionally one or more heteroatoms selected from the group consisting of piperazino, morpholino, piperidino; thiomorpholino, thiomorpholino-1-oxide, thiomorpholinon-1,1-dioxide, diazepane and pyrrolidino, wherein the nitrogen atoms may be substituted by a group selected from among phenyl, C 1-3 -alkylsulfonyl, C 1-3 -alkyl and -CO-C 1-3 -alkyl; R 3, R 4, R 5 denote independently from each other -C 1-3 -alkyl; or tautomers or pharmacologically acceptable acid addition salts thereof. A and A' are independently from each other -CH 2 - or -CH 2 -CH 2 -; R is selected from -N R 1 R 2, -N R 3 R 4 R 5 (+) Z 1 (-) and -OR 13; X denotes halogen; Z 1 (-) denotes halogen anion or an organic acid anion; Z 2 (-) denotes halogen anion or an organic acid anion; Z 3 (-) denotes halogen anion or an organic acid anion; Z 4 (-) denotes halogen anion or an organic acid anion; R 1 and R 2 are selected independently from each other from H, -C(NH 2)NH, -CN(CH 3) 2 N(CH 3) 2 + Z 2 -, -C 1-3 -alkyl, -C 2-4 -alkyl-N(CH 3) 2, -C 1-3 -alkyl-phenyl- R 12, -C 1-3 -alkyl-COOH, -C 1-4 -alkyl-CO- Y 2 - R 11, -CO-phenyl-CO-O- R 13, -CO-C 1-4 -alkyl, -CO-C 1-3 -alkyl-N R 6 R 7, -CO-C 1-3 -alkyl-N(CH 3) 3 + Z 3 -, -CO-C 1-4 -alkyl- Y 1 - R 9, -CO-O-C 1-4 -alkyl- R 8, -CO-NH-C 3-7 -cycloalkyl, -CO-NH-C 1-4 -alkyl, -CH 2 -CO-O-C 1-3 -alkyl, -CH 2 -CO-O-C 1-3 -alkyl-phenyl and -SO 2 - R 10; R 6 is selected from -C 1-3 -alkyl, H, -C 1-4 -alkyl-OH, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 7 is selected from -C 1-3 -alkyl, -CO-O-C 1-3 -alkyl, -C 1-4 -alkyl-OH, H, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 8 denotes H or phenyl; R 9 is selected from H, -C 1-3 -alkyl, OH, -N R 6 R 7 and =O; R 10 is C 1-3 -alkyl or an optionally substituted N-containing nonaromatic heterocycle; R 11 is selected from H, C 1-3 -alkyl, =O, -N(CH 3) 2 and -N(CH 3) 3 + Z 4 -; R 12 is selected from H, halogen, -COOH, -PO(OC 1-4 -alkyl)OH optionally substituted at the 2,3 or 4 position of the C 1-4 -alkyl group by -N(C 1-3 -alkyl) 2 or -N(C 1-3 -alkyl) 3 + Z 4 -, and -PO(OC 1-4 -alkyl) 2, -PO 2; R 13 is selected from H or C 1-4 -alkyl; Y 1 is selected from an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle, -N(C 1-3 -alkyl)-C 2-4 -alkyl-N(C 1-3 -alkyl) 2 and -N(C 1-3 -alkyl)-C 2-4 -alkyl-N + (C 1-3 alkyl) 3 Z 1 (-); Y 2 is an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle; R 6 is selected from -C 1-3 -alkyl, H, -C 1-4 -alkyl-OH, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 7 is selected from -C 1-3 -alkyl, -CO-O-C 1-3 -alkyl, -C 1-4 -alkyl-OH, H, -CH 2 -CO-O-C 1-3 -alkyl and -CH 2 COOH; R 8 denotes H or phenyl; R 9 is selected from H, -C 1-3 -alkyl, OH, -N R 6 R 7 and =O; R 10 is C 1-3 -alkyl or an optionally substituted N-containing nonaromatic heterocycle; R 11 is selected from H, C 1-3 -alkyl, =O, -N(CH 3) 2 and -N(CH 3) 3 + Z 4 -; R 12 is selected from H, halogen, -COOH, -PO(OC 1-4 -alkyl)OH optionally substituted at the 2,3 or 4 position of the C 1-4 -alkyl group by -N(C 1-3 -alkyl) 2 or -N(C 1-3 -alkyl) 3 + Z 4 -, and -PO(OC 1-4 -alkyl) 2, -PO 2; R 13 is selected from H or C 1-4 -alkyl; Y 1 is selected from an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle, -N(C 1-3 -alkyl)-C 2-4 -alkyl-N(C 1-3 -alkyl) 2 and -N(C 1-3 -alkyl)-C 2-4 -alkyl-N + (C 1-3 alkyl) 3 Z 1 (-); Y 2 is an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle;