A compound having formula: or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein: D 1 is phenyl substituted with heteroaryl; each E 1 is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, aminocarbonyl, C 1-8 alkoxycarbonylC 1-8 alkylene, C 1-8 alkoxycarbonylC 1-8 C 1-8 alkoxy, C 1-8 alkoxycarbonylamino, oxo, halo, cyano, haloC 1-8 alkyl, haloC 1-8 alkoxy, aminosulfonyl, heteroarylsulfinyl; amino, hydroxyl, C 1-8 arylalkylene, phenyl, aminoC 1-8 alkyl, aminoC 3-8 cycloalkyl, heterocyclyl, heteroaryl, C 1-8 acyl, C 1-8 alkylsulfonyl, acylamino and heterocyclylC 1-8 alkylene; the subscript n is 0, 1, 2, 3 or 4; the moiety: is either: (a) and wherein X and Y is each independently selected from the group consisting of: CH 2, NH, NCOCH 3 and S; (b) selected from the group consisting of: and wherein each R 8a and R 8b is independently H, hydroxyl, halo or if on adjacent carbon atoms, may be combined with the atoms to which they are attached to form a fused benzene ring; and each R 9a and R 9b is independently H, hydroxyl, halo or, if on adjacent carbon atoms, may be combined with the atoms to which they are attached to form a fused benzene ring; and the wavy line indicates the point of attachment to the rest of the molecule; or (c) wherein each R 8a and R 8b is independently H or may be combined with the atoms to which they are attached to form a fused benzene ring; and the wavy line indicates the point of attachment to the rest of the molecule; and "cycloalkyl" refers to a mono- or polycyclic aliphatic hydrocarbon group, which may form a bridged ring or a spiro ring, and which may have one or more double or triple bond(s). D 1 is phenyl substituted with heteroaryl; each E 1 is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, aminocarbonyl, C 1-8 alkoxycarbonylC 1-8 alkylene, C 1-8 alkoxycarbonylC 1-8 C 1-8 alkoxy, C 1-8 alkoxycarbonylamino, oxo, halo, cyano, haloC 1-8 alkyl, haloC 1-8 alkoxy, aminosulfonyl, heteroarylsulfinyl; amino, hydroxyl, C 1-8 arylalkylene, phenyl, aminoC 1-8 alkyl, aminoC 3-8 cycloalkyl, heterocyclyl, heteroaryl, C 1-8 acyl, C 1-8 alkylsulfonyl, acylamino and heterocyclylC 1-8 alkylene; the subscript n is 0, 1, 2, 3 or 4; (a) and wherein X and Y is each independently selected from the group consisting of: CH 2, NH, NCOCH 3 and S; (b) selected from the group consisting of: and wherein each R 8a and R 8b is independently H, hydroxyl, halo or if on adjacent carbon atoms, may be combined with the atoms to which they are attached to form a fused benzene ring; and each R 9a and R 9b is independently H, hydroxyl, halo or, if on adjacent carbon atoms, may be combined with the atoms to which they are attached to form a fused benzene ring; and the wavy line indicates the point of attachment to the rest of the molecule; or (c) wherein each R 8a and R 8b is independently H or may be combined with the atoms to which they are attached to form a fused benzene ring; and the wavy line indicates the point of attachment to the rest of the molecule; and "cycloalkyl" refers to a mono- or polycyclic aliphatic hydrocarbon group, which may form a bridged ring or a spiro ring, and which may have one or more double or triple bond(s).