A blood flow cessation system, comprising: a blood flow cessation device comprising: a catheter having a distal end portion, a proximal end portion, and an inflation lumen extending from the proximal end portion to the distal end portion; an expandable member comprising an inflatable balloon positioned at the distal end portion and being selectively expandable to stop blood flow through a vessel; a rapid exchange port formed in a sidewall of the catheter at a location proximal of the expandable member; and a structure defining a guidewire lumen extending from the rapid exchange port distally through the distal end portion of the catheter, with the expandable member having a proximal portion connected to the distal end portion of the catheter and a distal portion connected to a distal end of the structure defining the guidewire lumen, with the structure defining the guidewire lumen extending through the inflation lumen such that inflation fluid flowing therethrough to inflate the inflatable balloon flows around the guidewire lumen; and a treatment device; a guidewire extending through the rapid exchange port and through the distal end portion of the catheter; wherein the blood flow cessation device is configured to advance along the guidewire through a vessel puncture and into a vessel where the expandable member is expandable to limit blood flow in the vessel, characterized in that the treatment device comprises a large bore closure device, and the treatment device is configured to advance along the guidewire to the vessel puncture, and the blood flow cessation system further comprises an insertion sheath positionable in the vessel puncture, the blood flow cessation device being insertable through the insertion sheath into the vessel, with the treatment device being positioned on the guidewire external to the insertion sheath. a blood flow cessation device comprising: a catheter having a distal end portion, a proximal end portion, and an inflation lumen extending from the proximal end portion to the distal end portion; an expandable member comprising an inflatable balloon positioned at the distal end portion and being selectively expandable to stop blood flow through a vessel; a rapid exchange port formed in a sidewall of the catheter at a location proximal of the expandable member; and a structure defining a guidewire lumen extending from the rapid exchange port distally through the distal end portion of the catheter, with the expandable member having a proximal portion connected to the distal end portion of the catheter and a distal portion connected to a distal end of the structure defining the guidewire lumen, with the structure defining the guidewire lumen extending through the inflation lumen such that inflation fluid flowing therethrough to inflate the inflatable balloon flows around the guidewire lumen; and a catheter having a distal end portion, a proximal end portion, and an inflation lumen extending from the proximal end portion to the distal end portion; an expandable member comprising an inflatable balloon positioned at the distal end portion and being selectively expandable to stop blood flow through a vessel; a rapid exchange port formed in a sidewall of the catheter at a location proximal of the expandable member; and a structure defining a guidewire lumen extending from the rapid exchange port distally through the distal end portion of the catheter, with the expandable member having a proximal portion connected to the distal end portion of the catheter and a distal portion connected to a distal end of the structure defining the guidewire lumen, with the structure defining the guidewire lumen extending through the inflation lumen such that inflation fluid flowing therethrough to inflate the inflatable balloon flows around the guidewire lumen; and a treatment device; a guidewire extending through the rapid exchange port and through the distal end portion of the catheter; wherein the blood flow cessation device is configured to advance along the guidewire through a vessel puncture and into a vessel where the expandable member is expandable to limit blood flow in the vessel, characterized in that the treatment device comprises a large bore closure device, and the treatment device is configured to advance along the guidewire to the vessel puncture, and the blood flow cessation system further comprises an insertion sheath positionable in the vessel puncture, the blood flow cessation device being insertable through the insertion sheath into the vessel, with the treatment device being positioned on the guidewire external to the insertion sheath.