mhurhangee/ep-ind-claims huggingface dataset:
Modified PIN4 gene, the wild type of which is as identified in SEQ ID No. 1, encoding the protein of SEQ ID No. 5, or the wild type of which encodes a protein that has a sequence similarity of at least 80% to SEQ ID No. 5, which modified PIN4 gene encodes a protein that comprises a non-conservative amino acid substitution, which non-conservative amino acid substitution is a substitution of a negatively charged or uncharged amino acid with a positively charged amino acid, of a polar amino acid with a hydrophobic amino acid, of an uncharged polar amino acid with a hydrophobic amino acid, of a hydrophobic amino acid with a non-hydrophobic amino acid, or of a negatively charged amino acid with a positively charged or uncharged amino acid, in the intracellular loop of the protein structure as a result of the modification, and which modified protein is capable of inducing parthenocarpic fruit set when present in a plant.
A fitting, especially for mounting wall cupboards, comprising a mounting plate on which a cut-out section is provided, into which an eccentric disk (20, 20', 20") having an opening (23, 23') is inserted, a screw extending through said opening (23, 23'), whereby the opening (23, 23') on the eccentric disk (20, 20', 20") is designed in such a manner that the eccentric disk (20, 20', 20") can be placed on the shank of a wall-mounted screw (40, 40') with a screw head, characterized in that the mounting plate can be vertically and horizontally adjusted relative to the screw (40, 40') by rotating the eccentric disk (20, 20', 20"), whereby the cut-out section is formed as an elongate hole in the mounting plate.
A wire rope with a long splice connection, which wire rope includes several strands, wherein at least between two adjacent strands a support element is provided in the region of the long splice connection, characterized in that the support element is comprised of a homogenous profile member having a substantially trapezoidal cross section, or a substantially equilateral trapezoidal cross section with the oblique sides (9, 10) of the trapezoid being each concavely formed, against which the strands laterally bear.
A patient ceiling lift system, including: first and second motor units; first and second tension support members each coupled to a respective one of the first and second motor units, each motor unit being operable to change an operative length of its associated tension support member by extending or retracting the strap out of or into the motor unit, each tension support member including a coupling for attachment to a patient sling; a support frame assembly (32, 60, 62, 64) to which the first and second motor units are attached, the support frame assembly including a coupling for a ceiling carrier system; wherein the support frame assembly includes first and second independent pivotable support members to which the first and second motor units are attached, whereby the motor units are able to pivot on the support frame and relative to one another. first and second motor units; first and second tension support members each coupled to a respective one of the first and second motor units, each motor unit being operable to change an operative length of its associated tension support member by extending or retracting the strap out of or into the motor unit, each tension support member including a coupling for attachment to a patient sling; a support frame assembly (32, 60, 62, 64) to which the first and second motor units are attached, the support frame assembly including a coupling for a ceiling carrier system; wherein the support frame assembly includes first and second independent pivotable support members to which the first and second motor units are attached, whereby the motor units are able to pivot on the support frame and relative to one another.
A cardiopulmonary resuscitation, CPR, device for enhancing the delivery of CPR to a patient, the device comprising: a patient side for engagement with the chest of the patient; and a user side for engagement with the hands of a user delivering CPR to the patient; characterized in that the CPR device further comprises: an actuator configured to at least partially alter the external form of one or more of the patient side and the user side so as to regulate a shape profile of the one or more of the patient side and the user side. a patient side for engagement with the chest of the patient; and a user side for engagement with the hands of a user delivering CPR to the patient; characterized in that the CPR device further comprises: an actuator configured to at least partially alter the external form of one or more of the patient side and the user side so as to regulate a shape profile of the one or more of the patient side and the user side.
A method for increasing the color value change by increasing the lightness of dyed material comprising the following steps: (a) applying a hygroscopic substance to said dyed material, (b) dwelling the dyed material of step a) at least 5 minutes up to 24 hours, or even longer, and (c) applying ozone gas to said material of (b) in order to obtain the desired change in color intensity, and wherein the ozone activity is increased by the hygroscopic substance. (a) applying a hygroscopic substance to said dyed material, (b) dwelling the dyed material of step a) at least 5 minutes up to 24 hours, or even longer, and (c) applying ozone gas to said material of (b) in order to obtain the desired change in color intensity, and wherein the ozone activity is increased by the hygroscopic substance.
A composition comprising a (i) high pressure polyolefin free of silane functionality, and (ii) hydrophobic polyether polyol of which at least 50 weight percent based on the total weight of the bulk polymer of polyether polyol of its molecules comprise no more than a single hydroxyl functionality.
A packing method for folding a blank on a packing machine; the packing method comprising the steps of: engaging a first panel of the blank, inside a store, by means of a first suction pickup head; engaging a second panel of the blank, inside the store, by means of a second suction pickup head; and moving the pickup heads (21, 22) from a withdrawal position at the store to a release position at a packing conveyor, to insert the blank inside a pocket on the packing conveyor; and releasing the blank, folded into a 'U', inside the pocket on the packing conveyor; the packing method being characterized by comprising the further step, as the pickup heads are moved from the withdrawal position to the release position, of producing a relative movement between the first pickup head and the second pickup head to fold the blank into a 'U' before the blank is inserted into the pocket on the packing conveyor. engaging a first panel of the blank, inside a store, by means of a first suction pickup head; engaging a second panel of the blank, inside the store, by means of a second suction pickup head; and moving the pickup heads (21, 22) from a withdrawal position at the store to a release position at a packing conveyor, to insert the blank inside a pocket on the packing conveyor; and releasing the blank, folded into a 'U', inside the pocket on the packing conveyor; the packing method being characterized by comprising the further step, as the pickup heads are moved from the withdrawal position to the release position, of producing a relative movement between the first pickup head and the second pickup head to fold the blank into a 'U' before the blank is inserted into the pocket on the packing conveyor.
A compound represented by the following chemical structural formula: or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of an eye disease selected from the group consisting of age-related macular degeneration, diabetic retinopathy, macular edema, retinal vein occlusion, neovascular maculopathy and neovascular glaucoma.
A method for use in the transmission of signals between at least one first node and at least one second node via at least one intermediate node, said nodes being part of a transmission channel, said method comprising at said intermediate node the steps of: receiving a plurality of signals from said at least one first node; acquiring a channel quality condition of the transmission channel; selecting, depending on said acquired channel quality condition, as transmission mode either transmitting said plurality of signals to said at least one second node; or performing the steps of: concatenating said plurality of signals as received to obtain a concatenated signal; transmitting said concatenated signal to said second node; characterized in that concatenating comprises combining said plurality of signals as received and adding a guard interval at least at the beginning of the combination, without including a guard interval in between said plurality of signals. receiving a plurality of signals from said at least one first node; acquiring a channel quality condition of the transmission channel; selecting, depending on said acquired channel quality condition, as transmission mode either transmitting said plurality of signals to said at least one second node; or performing the steps of: concatenating said plurality of signals as received to obtain a concatenated signal; transmitting said concatenated signal to said second node; concatenating said plurality of signals as received to obtain a concatenated signal; transmitting said concatenated signal to said second node; characterized in that concatenating comprises combining said plurality of signals as received and adding a guard interval at least at the beginning of the combination, without including a guard interval in between said plurality of signals.
A method for use in a radio base station for communicating with a user equipment over a channel structured in transmission time intervals in a radio communications network, which user equipment is served in a cell controlled by the radio base station, the method comprises - receiving information regarding active cells and/or active user equipments, and/or receiving information on a transmission scheme being used by the active cells and/or active user equipments - identifying (203,303,402,402B) an interference situation based on the received information, the interference situation being associated with a transmission time interval, and where the interference situation is identified in the cell from an indexed set of interference situations, wherein each interference situation is connected to a correction value via an index; - selecting (204,304,403,403B) a correction value associated with the identified interference situation; - determining (205,305,404,404B) a radio transmission parameter using the selected correction value; and - transmitting (206,306,405,405B) information, to the user equipment, based on the determined radio transmission parameter. - receiving information regarding active cells and/or active user equipments, and/or receiving information on a transmission scheme being used by the active cells and/or active user equipments - identifying (203,303,402,402B) an interference situation based on the received information, the interference situation being associated with a transmission time interval, and where the interference situation is identified in the cell from an indexed set of interference situations, wherein each interference situation is connected to a correction value via an index; - selecting (204,304,403,403B) a correction value associated with the identified interference situation; - determining (205,305,404,404B) a radio transmission parameter using the selected correction value; and - transmitting (206,306,405,405B) information, to the user equipment, based on the determined radio transmission parameter.
A method for controlled shallow etching of a surface of a substrate (1702, 1802, 1902) comprising the steps of: providing a reduced pressure chamber; forming a gas cluster ion beam comprising gas cluster ions within the reduced pressure chamber; accelerating the gas cluster ions to form an accelerated gas cluster ion beam along a beam path within the reduced pressure chamber; promoting fragmentation and/or dissociation of at least a portion of the accelerated gas cluster ions along the beam path; removing charged particles from the beam path to form an accelerated neutral beam along the beam path in the reduced pressure chamber; holding the substrate (1702, 1802, 1902) in the beam path; treating a portion of a surface of the substrate (1702, 1802, 1902) by irradiating it with the accelerated neutral beam to form a shallow modified layer (1728, 1828, 1934) on the irradiated portion of the surface, the shallow modified layer (1728, 1828, 1934), overlying unmodified substrate (1702, 1802, 1902) beneath, wherein the shallow modified layer (1728, 1828, 1934) is more susceptible to chemical etching using etching agents that otherwise are not highly active or are inactive for etching the unmodified substrate (1702, 1802, 1902) beneath; applying a chemical etchant which etches the surface having the shallow modified layer (1728, 1828, 1934), formed by the irradiation, to preferentially remove material in the shallow modified layer (1728, 1828, 1934) on the surface and wherein the etching stops at the unmodified substrate (1702, 1802, 1902) beneath. providing a reduced pressure chamber; forming a gas cluster ion beam comprising gas cluster ions within the reduced pressure chamber; accelerating the gas cluster ions to form an accelerated gas cluster ion beam along a beam path within the reduced pressure chamber; promoting fragmentation and/or dissociation of at least a portion of the accelerated gas cluster ions along the beam path; removing charged particles from the beam path to form an accelerated neutral beam along the beam path in the reduced pressure chamber; holding the substrate (1702, 1802, 1902) in the beam path; treating a portion of a surface of the substrate (1702, 1802, 1902) by irradiating it with the accelerated neutral beam to form a shallow modified layer (1728, 1828, 1934) on the irradiated portion of the surface, the shallow modified layer (1728, 1828, 1934), overlying unmodified substrate (1702, 1802, 1902) beneath, wherein the shallow modified layer (1728, 1828, 1934) is more susceptible to chemical etching using etching agents that otherwise are not highly active or are inactive for etching the unmodified substrate (1702, 1802, 1902) beneath; applying a chemical etchant which etches the surface having the shallow modified layer (1728, 1828, 1934), formed by the irradiation, to preferentially remove material in the shallow modified layer (1728, 1828, 1934) on the surface and wherein the etching stops at the unmodified substrate (1702, 1802, 1902) beneath.
An SMA actuation apparatus comprising: a support structure; a movable element movably supported on the support structure; an arrangement of three or more SMA actuator wires mechanically connected between the support structure and the movable element, the SMA actuator wires being arranged on contraction thereof to drive displacement of the movable element relative to the support structure, a group of three or more of the SMA actuator wires having an interconnection at the movable element that electrically connects the group of SMA actuator wires together; and a control circuit electrically connected to the group of SMA actuator wires at the support structure, without the control circuit being electrically connected to the SMA actuator wires at the movable element, for supplying drive signals to the SMA actuator wires. a support structure; a movable element movably supported on the support structure; an arrangement of three or more SMA actuator wires mechanically connected between the support structure and the movable element, the SMA actuator wires being arranged on contraction thereof to drive displacement of the movable element relative to the support structure, a group of three or more of the SMA actuator wires having an interconnection at the movable element that electrically connects the group of SMA actuator wires together; and a control circuit electrically connected to the group of SMA actuator wires at the support structure, without the control circuit being electrically connected to the SMA actuator wires at the movable element, for supplying drive signals to the SMA actuator wires.
A pulp distribution compartment arrangement for pulp filter equipment utilizing cylinder-based dewatering, comprising: - a distribution compartment; - an exit opening from said distribution compartment, said exit opening having an elongated shape with a main extension in a first direction; - a inlet to said distribution compartment at a side of the distribution compartment opposite to said exit opening, said inlet entering said distribution compartment at an inlet position in said first direction; - a distributer screw rotatably arranged in said distribution compartment with a rotation axis parallel to said first direction; whereby an elongated flow passage is defined between said distributer screw and a side wall of said distribution compartment, said side wall extending in a flow direction between said inlet and said exit opening, characterized by - a throttle surface provided at said side wall in a throttle position along said first direction corresponding to said inlet position; whereby said throttle surface provides a restriction of said elongated flow passage at said throttle position in comparison to other positions in said first direction. - a distribution compartment; - an exit opening from said distribution compartment, said exit opening having an elongated shape with a main extension in a first direction; - a inlet to said distribution compartment at a side of the distribution compartment opposite to said exit opening, said inlet entering said distribution compartment at an inlet position in said first direction; - a distributer screw rotatably arranged in said distribution compartment with a rotation axis parallel to said first direction; whereby an elongated flow passage is defined between said distributer screw and a side wall of said distribution compartment, said side wall extending in a flow direction between said inlet and said exit opening, characterized by - a throttle surface provided at said side wall in a throttle position along said first direction corresponding to said inlet position; - a throttle surface provided at said side wall in a throttle position along said first direction corresponding to said inlet position; whereby said throttle surface provides a restriction of said elongated flow passage at said throttle position in comparison to other positions in said first direction.
A method of bonding a polymer film, comprising contacting a surface of a polymer film which is a polyvinyl alcohol resin film with a surface of a material to be bonded and laser welding an interface between the surface of the polymer film and the surface of the material to be bonded, wherein water is absorbed at least in the interface side of the polymer film, the interface side is irradiated with laser light, and the laser light is absorbed by the absorbed water to perform the laser welding.
A method for producing a flame-retardant resin composition comprising, as a polymer component: 50 to 95% by mass of copolymer of ethylene and a vinyl ester, 5 to 50% by mass of propylene copolymer wherein the content of an α-olefin except for propylene is 10 to 60% by mole, and 0 to 40% by mass of polypropylene wherein the content of an α-olefin except for propylene is less than 10% by mole; wherein the total of components,, and is 100% by mass; and further comprising, with respect to 100 parts by mass of the total of components,, and: 50 to 350 parts by mass of metal hydroxide, 0.1 to 50 parts by mass of zinc borate, and 0.1 to 50 parts by mass of powdered silicone; wherein the mass ratio [D/(E+F)] of component with respect to the total amount of components and is 15 or less, wherein the process comprises melt-kneading the polymer component comprising at least copolymer of ethylene and a vinyl ester and propylene copolymer to produce a polymer composition; and melt-kneading at least polymer composition, metal hydroxide, zinc borate, and powdered silicone. 50 to 95% by mass of copolymer of ethylene and a vinyl ester, 5 to 50% by mass of propylene copolymer wherein the content of an α-olefin except for propylene is 10 to 60% by mole, and 0 to 40% by mass of polypropylene wherein the content of an α-olefin except for propylene is less than 10% by mole; wherein the total of components,, and is 100% by mass; and further comprising, with respect to 100 parts by mass of the total of components,, and: 50 to 350 parts by mass of metal hydroxide, 0.1 to 50 parts by mass of zinc borate, and 0.1 to 50 parts by mass of powdered silicone; wherein the mass ratio [D/(E+F)] of component with respect to the total amount of components and is 15 or less, wherein the process comprises melt-kneading the polymer component comprising at least copolymer of ethylene and a vinyl ester and propylene copolymer to produce a polymer composition; and melt-kneading at least polymer composition, metal hydroxide, zinc borate, and powdered silicone.
Conveyor device for crop, with a conveyor rotor, a conveyor channel and a conveyor channel floor, wherein conveyor rotor and conveyor channel floor are arranged spaced apart from each other in a changeable manner and at least partially delimit the conveyor channel, wherein the conveyor channel floor can be changed in distance from the conveyor rotor radially with respect to the axis of rotation of the conveyor rotor by means of at least one adjustment device, characterized in that the conveyor channel floor is divided in the direction of the axis of rotation into at least two floor segments (28', 28", 28"') which can be changed in distance from the conveyor rotor separately from one another in each case by means of an adjustment device.
A compound of Formula I: or a pharmaceutically acceptable salt or a stereoisomer thereof, for use in a method of treating a disease or disorder associated with PD-1/PD-L1 interaction in combination with one or more other therapies, wherein the disease or disorder is cancer or an infection, wherein: R 1 is methyl, CN, F, Cl, or Br; R 2 is methyl, CN, F, Cl, or Br; and R 3 is H, C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-2 alkyl-, C 6-10 aryl, C 6-10 aryl-C 1-2 alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl or 4- to 6-membered heterocycloalkyl-C 1-2 alkyl-, wherein the 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- each has one or two heteroatoms as ring members selected from O, N and S, and wherein the C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-2 alkyl-, C 6-10 aryl, C 6-10 aryl-C 1-2 alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- of R 3 are each optionally substituted with 1 or 2 substituents independently selected from CONH 2, SO 2 NH 2, COOH, OH, CON(CH 3) 2, CH 3, F, Cl, Br, CN, ethyl, and propyl. R 1 is methyl, CN, F, Cl, or Br; R 2 is methyl, CN, F, Cl, or Br; and R 3 is H, C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-2 alkyl-, C 6-10 aryl, C 6-10 aryl-C 1-2 alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl or 4- to 6-membered heterocycloalkyl-C 1-2 alkyl-, wherein the 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- each has one or two heteroatoms as ring members selected from O, N and S, and wherein the C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-2 alkyl-, C 6-10 aryl, C 6-10 aryl-C 1-2 alkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heteroaryl-C 1-2 alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- of R 3 are each optionally substituted with 1 or 2 substituents independently selected from CONH 2, SO 2 NH 2, COOH, OH, CON(CH 3) 2, CH 3, F, Cl, Br, CN, ethyl, and propyl.