mhurhangee/ep-ind-claims huggingface dataset:
An improved process for preparation of Indocyanine green of Formula having high purity, wherein the process comprises steps of: a) reacting 1,1,2-trimethyl-1H-benzo[e]indole of Formula with 1,4-butane sultone of Formula in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula; b) condensing 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula in presence of sodium acetate and an alcohol; and c) extracting the title compound formula with an ester solvent. a) reacting 1,1,2-trimethyl-1H-benzo[e]indole of Formula with 1,4-butane sultone of Formula in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula; b) condensing 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula in presence of sodium acetate and an alcohol; and c) extracting the title compound formula with an ester solvent.
A rotor for a gas turbine engine, comprising: a rotor hub including at least one rotor lug; and a heat shield engaging the at least one rotor lug; wherein the heat shield and the rotor lug define a cooling passage, the lug includes a first rail and a second rail extending from a radially outer end thereof, and the heat shield includes a planar portion with a first longitudinal hook on a first side of the planar portion for engaging the first rail and a second longitudinal hook on an opposite second side of the planar portion for engaging the second rail, characterised in that the rotor further comprises: at least one turbulent structure located on at least one of the rotor hub or the heat shield and configured to increase turbulence of a cooling fluid flowing through the cooling passage. a rotor hub including at least one rotor lug; and a heat shield engaging the at least one rotor lug; wherein the heat shield and the rotor lug define a cooling passage, the lug includes a first rail and a second rail extending from a radially outer end thereof, and the heat shield includes a planar portion with a first longitudinal hook on a first side of the planar portion for engaging the first rail and a second longitudinal hook on an opposite second side of the planar portion for engaging the second rail, characterised in that the rotor further comprises: at least one turbulent structure located on at least one of the rotor hub or the heat shield and configured to increase turbulence of a cooling fluid flowing through the cooling passage.
A rotary indexing device (130; 230), configured for use in connection with a medical instrument, the rotary indexing device comprising: a base (131; 231); a rotary member (132; 232) rotatably coupled to the base and configured to be coupled to the medical instrument, the rotary member and base engaged such that interaction between the base and the rotary member releasably couples rotation of the rotary member with respect to the base at one or more stops such that rotation of the rotary member is configured to rotate the medical instrument at positions corresponding to the one or more stops, the rotary indexing device comprising one or more detents (136, 137; 236, 237) configured to releasably couple rotation of the rotary member with respect to the base at the one or more stops such that the rotary member may only rotate with respect to the base when the one or more detents are not engaged; and a medical device characterised in that the medical device is coupled to the rotary member such that rotation of the rotary member also rotates the medical device, the medical device comprising an elongate member having a curved distal tip and a pointer coupled adjacent a proximal end of the elongate member, the pointer disposed such that a portion of the pointer lies in substantially the same plane as the curved distal tip. a base (131; 231); a rotary member (132; 232) rotatably coupled to the base and configured to be coupled to the medical instrument, the rotary member and base engaged such that interaction between the base and the rotary member releasably couples rotation of the rotary member with respect to the base at one or more stops such that rotation of the rotary member is configured to rotate the medical instrument at positions corresponding to the one or more stops, the rotary indexing device comprising one or more detents (136, 137; 236, 237) configured to releasably couple rotation of the rotary member with respect to the base at the one or more stops such that the rotary member may only rotate with respect to the base when the one or more detents are not engaged; and a medical device characterised in that the medical device is coupled to the rotary member such that rotation of the rotary member also rotates the medical device, the medical device comprising an elongate member having a curved distal tip and a pointer coupled adjacent a proximal end of the elongate member, the pointer disposed such that a portion of the pointer lies in substantially the same plane as the curved distal tip.
Lifting apparatus for a lifting crane, adapted to carry an elongated component, especially a rotor blade of a wind turbine, comprising a frame with at least two support arms for carrying the component, characterized in that at least one flap-like interaction means for interacting with blowing wind is provided at the frame or a support arm, which flap-like interaction means is movable from a non-working position in a working position, in which it is set against the wind, wherein the flap-like interaction means is linearly movable, or in a combined linear and curved movement; and the at least one or each flap-like interaction means is shiftable along the frame or the support arm to change its frame or arm position. wherein the flap-like interaction means is linearly movable, or in a combined linear and curved movement; and the at least one or each flap-like interaction means is shiftable along the frame or the support arm to change its frame or arm position.
A sustained release composition for use in the treatment of arthritis, comprising: liposomes; and one or more therapeutic agents, characterized in that the liposomes comprise a mixture of a first phospholipid and a second phospholipid and cholesterol, the first phospholipid being DOPC and the second phospholipid being DOPG, wherein the mole percent of DOPC:DOPG:cholesterol of the liposomes is about 56.25 to 72.5: 7.5 to 18.75: 20 to 25, wherein the liposomes are in an aqueous suspension, and wherein the therapeutic agent is not covalently bound to a phospholipid, and the sustained release composition is intraarticularly injected into a joint of a subject in need of treatment for arthritis. liposomes; and one or more therapeutic agents, characterized in that the liposomes comprise a mixture of a first phospholipid and a second phospholipid and cholesterol, the first phospholipid being DOPC and the second phospholipid being DOPG, wherein the mole percent of DOPC:DOPG:cholesterol of the liposomes is about 56.25 to 72.5: 7.5 to 18.75: 20 to 25, wherein the liposomes are in an aqueous suspension, and wherein the therapeutic agent is not covalently bound to a phospholipid, and the sustained release composition is intraarticularly injected into a joint of a subject in need of treatment for arthritis.
A process for purifying contaminated water, preferably of liquid manure provenance, comprising: • performing a first purification step including exposing the contaminated water in vapor phase to a solvent, preferably hexylalcohol, in liquid phase to thereby substantially rid the contaminated water vapor of contaminants by transfer of the contaminants into the liquid solvent; • recuperating (29, 22) mixed contaminated liquid solvent and liquid water condensing during the first purification step, the solvent used forming a heterogeneous azeotrope with water; • vaporizing the recuperated liquids into a contaminated azeotropic vapor and additionally exposing the contaminated azeotropic vapor to the solvent in liquid phase to thereby substantially rid the contaminated azeotropic vapor of contaminants by transfer of the contaminants into the liquid solvent in the first purification step; • condensing the decontaminated water and solvent vapors from the first purification step together into a heterogeneous liquid; substantially separating the heterogeneous liquid into a liquid water constituent and a liquid solvent constituent and channeling the separated liquid solvent constituent into the first purification step; • subsequently to the first purification step, performing a second purification step including exposing the decontaminated water in liquid phase to water in vapor phase to thereby substantially rid the decontaminated liquid water of solvent by transfer of the solvent into the water vapor. • performing a first purification step including exposing the contaminated water in vapor phase to a solvent, preferably hexylalcohol, in liquid phase to thereby substantially rid the contaminated water vapor of contaminants by transfer of the contaminants into the liquid solvent; • recuperating (29, 22) mixed contaminated liquid solvent and liquid water condensing during the first purification step, the solvent used forming a heterogeneous azeotrope with water; • vaporizing the recuperated liquids into a contaminated azeotropic vapor and additionally exposing the contaminated azeotropic vapor to the solvent in liquid phase to thereby substantially rid the contaminated azeotropic vapor of contaminants by transfer of the contaminants into the liquid solvent in the first purification step; • condensing the decontaminated water and solvent vapors from the first purification step together into a heterogeneous liquid; substantially separating the heterogeneous liquid into a liquid water constituent and a liquid solvent constituent and channeling the separated liquid solvent constituent into the first purification step; • subsequently to the first purification step, performing a second purification step including exposing the decontaminated water in liquid phase to water in vapor phase to thereby substantially rid the decontaminated liquid water of solvent by transfer of the solvent into the water vapor.
A downhole tool, comprising: a housing defining a first bore; a mandrel disposed in the first bore and defining a second bore, the mandrel having first and second mandrel sections (50,60), the first mandrel section defining a first cross-port for communicating fluid in the second bore with an annular space between the mandrel and the housing; a seat disposed in the first bore of the housing between the first and second mandrel sections (50,60), the seat movable to a constricted state in the first bore and movable to an expanded state in the first bore; and a piston disposed in the annular space, the piston in a first position at least temporarily supporting the seat in the constricted state, the piston movable in response to the communicated fluid to a second position removing at least temporary support of the seat. a housing defining a first bore; a mandrel disposed in the first bore and defining a second bore, the mandrel having first and second mandrel sections (50,60), the first mandrel section defining a first cross-port for communicating fluid in the second bore with an annular space between the mandrel and the housing; a seat disposed in the first bore of the housing between the first and second mandrel sections (50,60), the seat movable to a constricted state in the first bore and movable to an expanded state in the first bore; and a piston disposed in the annular space, the piston in a first position at least temporarily supporting the seat in the constricted state, the piston movable in response to the communicated fluid to a second position removing at least temporary support of the seat.
A light control material for the representation of different colors, comprising: a material body including a plurality of microstructures (43, 52, 55, 67, 75,130, 146, 148, 208), each microstructure having a stepped reflective microstructure designed to reflect a bandwidth of light by means of constructive interference effects in accordance with the design of the particular microstructure, the microstructures incorporating color information that upon reflection of light from the microstructures provides a two-dimensional image, characterized in that a first one of said microstructures is comprised of steps having a height differing from the height of steps of a second one of said microstructures, the first and second microstructures respectively reflecting wavelengths of visible light approximately twice the height of the respective steps without the need of a multiple layer device, and the bandwidth being defined at least in part by the number of steps in each microstructure. a material body including a plurality of microstructures (43, 52, 55, 67, 75,130, 146, 148, 208), each microstructure having a stepped reflective microstructure designed to reflect a bandwidth of light by means of constructive interference effects in accordance with the design of the particular microstructure, the microstructures incorporating color information that upon reflection of light from the microstructures provides a two-dimensional image, characterized in that a first one of said microstructures is comprised of steps having a height differing from the height of steps of a second one of said microstructures, the first and second microstructures respectively reflecting wavelengths of visible light approximately twice the height of the respective steps without the need of a multiple layer device, and the bandwidth being defined at least in part by the number of steps in each microstructure.
A computer-implemented method, comprising: receiving, by a management code embedded in mobile app code of a first instance of a mobile app being executed on a mobile device, an indication that the first instance of the mobile app has performed an operation affecting mobile app data of the first instance of the mobile app, wherein an issue exists with the first instance of the mobile app; storing, by the management code embedded in the mobile app code of the first instance of the mobile app, at least a portion of the mobile app data to a remote storage system based on the indication, wherein the mobile app data stored at the remote storage system is accessible by a device management server, wherein the device management server is configured to send to the remote storage system a command to provide the mobile app data to a remote device of a technician, wherein a second instance of the mobile app is launched on the remote device, wherein the mobile app data is provided from the remote storage system to a local storage of the remote device, wherein the mobile app data is loaded in the second instance of the mobile app to recreate the issue that exists with the first instance of the mobile app, wherein in response to diagnose and resolve the issue associated with the first instance of the mobile app by a technician, a library embedded in the second instance of the mobile app synchronizes changed mobile app data to the remote storage system; and synchronizing the synchronized mobile app data stored at the remote storage system with the first instance of the mobile app. receiving, by a management code embedded in mobile app code of a first instance of a mobile app being executed on a mobile device, an indication that the first instance of the mobile app has performed an operation affecting mobile app data of the first instance of the mobile app, wherein an issue exists with the first instance of the mobile app; storing, by the management code embedded in the mobile app code of the first instance of the mobile app, at least a portion of the mobile app data to a remote storage system based on the indication, wherein the mobile app data stored at the remote storage system is accessible by a device management server, wherein the device management server is configured to send to the remote storage system a command to provide the mobile app data to a remote device of a technician, wherein a second instance of the mobile app is launched on the remote device, wherein the mobile app data is provided from the remote storage system to a local storage of the remote device, wherein the mobile app data is loaded in the second instance of the mobile app to recreate the issue that exists with the first instance of the mobile app, wherein in response to diagnose and resolve the issue associated with the first instance of the mobile app by a technician, a library embedded in the second instance of the mobile app synchronizes changed mobile app data to the remote storage system; and synchronizing the synchronized mobile app data stored at the remote storage system with the first instance of the mobile app.
A method of making a labeled oligonucleotide for use as a hybridization probe in a PCR reaction comprising: (a) providing a fluorescent dye that is a rhodamine derivative wherein said fluorescent dye is attached with a bifunctional linker molecule; (b) binding a reactive group to the fluorescent dye via the bifunctional linker molecule for incorporating said fluorescent dye within the oligonucleotide; (c) incorporating the fluorescent dye between two internal nucleotides of the oligonucleotide, with the proviso that the fluorescent dye is not incorporated at the 5' terminus of the oligonucleotide, wherein the bifunctional linker molecule is consisting of L-threoninol or (2R,3R)-2-amino-1,3-butanediol. (a) providing a fluorescent dye that is a rhodamine derivative wherein said fluorescent dye is attached with a bifunctional linker molecule; (b) binding a reactive group to the fluorescent dye via the bifunctional linker molecule for incorporating said fluorescent dye within the oligonucleotide; (c) incorporating the fluorescent dye between two internal nucleotides of the oligonucleotide, with the proviso that the fluorescent dye is not incorporated at the 5' terminus of the oligonucleotide,
A compound of formula: wherein X 1 is O or NH; n is an integer between 1 to 4; R 1 is hydrogen, cyano, -C R 1a, -C NR 1b R 1c, heteroaryl or CH 2 OH; R 1a is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl or heteroaryl; R 1b and R 1c are each independently hydrogen, C 1 -C 6 alkyl, phenyl or heteroaryl, wherein said C 1 -C 6 alkyl, said phenyl or said heteroaryl are optionally substituted with one or more, particularly one to three substituents independently selected from the group consisting of hydroxy, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl and haloC 1 -C 6 alkoxy; R 2a is hydrogen or C 1 -C 6 alkyl; R 2b is haloC 1 -C 6 alkyl, C 1 -C 6 alkyl, phenyl or heteroaryl, wherein said phenyl or said heteroaryl are optionally substituted with one or more, particularly with one or two substituents independently selected from the group consisting of hydroxy, halogen, C 1 -C 6 alkyl and haloC 1 -C 6 alkyl; R 3a and R 3b are each independently phenyl or heteroaryl, wherein said phenyl or said heteroaryl are optionally substituted with one or more, particularly one to three substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl and haloC 1 -C 6 alkyl; or pharmaceutically acceptable salts. X 1 is O or NH; n is an integer between 1 to 4; R 1 is hydrogen, cyano, -C R 1a, -C NR 1b R 1c, heteroaryl or CH 2 OH; R 1a is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl or heteroaryl; R 1b and R 1c are each independently hydrogen, C 1 -C 6 alkyl, phenyl or heteroaryl, wherein said C 1 -C 6 alkyl, said phenyl or said heteroaryl are optionally substituted with one or more, particularly one to three substituents independently selected from the group consisting of hydroxy, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl and haloC 1 -C 6 alkoxy; R 2a is hydrogen or C 1 -C 6 alkyl; R 2b is haloC 1 -C 6 alkyl, C 1 -C 6 alkyl, phenyl or heteroaryl, wherein said phenyl or said heteroaryl are optionally substituted with one or more, particularly with one or two substituents independently selected from the group consisting of hydroxy, halogen, C 1 -C 6 alkyl and haloC 1 -C 6 alkyl; R 3a and R 3b are each independently phenyl or heteroaryl, wherein said phenyl or said heteroaryl are optionally substituted with one or more, particularly one to three substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl and haloC 1 -C 6 alkyl; or pharmaceutically acceptable salts.
Sliding door assembly, comprising a fixed frame, a horizontally displaceable door leaf and a drive device for displacing the door leaf, which drive device comprises a drive motor, arranged on the leaf, having a gear wheel which cooperates with a toothed belt arranged on the frame, wherein the toothed belt wraps around the gear wheel over a partial circumference of the gear wheel, and in that at least two teeth of the gear wheel are simultaneously fully engaged with at least two teeth of the toothed belt, wherein a first deflecting element (78, 110) formed as a deflecting roll and a second deflecting element (80, 112) formed as a deflecting roll are provided each of which cooperate with a rear side of the toothed belt, wherein the first deflecting element (78, 110), the second deflecting element (80, 112) and the gear wheel are arranged on a support and have axes of rotation (86, 88, 100) which are parallel to each other, wherein the toothed belt is arranged on a horizontal frame part, at the top when in the installation position, of the fixed frame, and wherein a drive axis of the drive motor is oriented in the vertical direction, characterized in that the axes of rotation (86, 88) of the deflecting rolls and an axis of rotation of the gear wheel are arranged within one plane, or the axes of rotation (86, 88) of the deflecting rolls are arranged within one plane and an axis of rotation of the gear wheel is spaced apart by at most 20 mm from said plane, and in that the frame part is formed as a sliding guide which is open to the bottom and in which the support is slidably arranged.
A catheter system for treating a treatment site within or adjacent to a vessel wall or heart valve, the catheter system comprising: a first light source that generates light energy; a plurality of light guides that are each configured to alternatingly receive light energy from the first light source, each light guide having a guide proximal end; a multiplexer that receives the light energy from the first light source, the multiplexer alternatingly directing the light energy from the first light source to each of the plurality of light guides; and a multiplexer alignment system that is operatively coupled to the multiplexer, the multiplexer alignment system including a second light source that generates a probe source beam that scans the guide proximal end of each of the plurality of light guides; and a first beamsplitter that receives a source beam from the first light source and the probe source beam from the second light source, the first beamsplitter being configured to direct each of the source beam and the probe source beam toward the guide proximal end of each of the plurality of light guides. a first light source that generates light energy; a plurality of light guides that are each configured to alternatingly receive light energy from the first light source, each light guide having a guide proximal end; a multiplexer that receives the light energy from the first light source, the multiplexer alternatingly directing the light energy from the first light source to each of the plurality of light guides; and a multiplexer alignment system that is operatively coupled to the multiplexer, the multiplexer alignment system including a second light source that generates a probe source beam that scans the guide proximal end of each of the plurality of light guides; and a first beamsplitter that receives a source beam from the first light source and the probe source beam from the second light source, the first beamsplitter being configured to direct each of the source beam and the probe source beam toward the guide proximal end of each of the plurality of light guides.