mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula or a pharmaceutically acceptable salt thereof: wherein: L represents a binding moiety selected from a cationic anti-microbial peptide linked to X 1 by an amine; S 1 represents a bond or a spacer selected from a -(CH 2) a - or -(CH 2) b -(CH 2 -CH 2 -O) c -(CH 2) d -group, wherein one to five of said -CH 2 - groups may optionally be substituted by a - C NH- or -NHC - group; a represents an integer selected from 1 to 40; b represents an integer selected from 0 to 25; c represents an integer selected from 1 to 20; d represents an integer selected from 1 to 15; S 2 represents a spacer selected from a -(CH 2) e - or -(CH 2) f -(CH 2 -CH 2 -O) g -(CH 2) h - group, wherein one to three of said -CH 2 - groups may optionally be substituted by a -C NH- or - NHC - group; e represents an integer selected from 1 to 20; f represents an integer selected from 1 to 10; g represents an integer selected from 1 to 15; h represents an integer selected from 1 to 5; X 1 represents a bond or -C -; Y 1 and Y 2 independently represent a bond, -O-, -S-, -NH-, -C -, -NHC - or -C NH-group; F represents a carbohydrate molecule capable of binding to a human anti-alpha-galactosyl antibody; m represents an integer selected from 1 to 5; and Cy represents phenyl, biphenyl or triphenyl, such that when Cy represents biphenyl or triphenyl, said -Y 1 -S 1 -X 1 -L group may be present on any of said phenyl rings and said [F-S 2 -Y 2] m - group or groups may be present on any of said phenyl rings. L represents a binding moiety selected from a cationic anti-microbial peptide linked to X 1 by an amine; S 1 represents a bond or a spacer selected from a -(CH 2) a - or -(CH 2) b -(CH 2 -CH 2 -O) c -(CH 2) d -group, wherein one to five of said -CH 2 - groups may optionally be substituted by a - C NH- or -NHC - group; a represents an integer selected from 1 to 40; b represents an integer selected from 0 to 25; c represents an integer selected from 1 to 20; d represents an integer selected from 1 to 15; S 2 represents a spacer selected from a -(CH 2) e - or -(CH 2) f -(CH 2 -CH 2 -O) g -(CH 2) h - group, wherein one to three of said -CH 2 - groups may optionally be substituted by a -C NH- or - NHC - group; e represents an integer selected from 1 to 20; f represents an integer selected from 1 to 10; g represents an integer selected from 1 to 15; h represents an integer selected from 1 to 5; X 1 represents a bond or -C -; Y 1 and Y 2 independently represent a bond, -O-, -S-, -NH-, -C -, -NHC - or -C NH-group; F represents a carbohydrate molecule capable of binding to a human anti-alpha-galactosyl antibody; m represents an integer selected from 1 to 5; and Cy represents phenyl, biphenyl or triphenyl, such that when Cy represents biphenyl or triphenyl, said -Y 1 -S 1 -X 1 -L group may be present on any of said phenyl rings and said [F-S 2 -Y 2] m - group or groups may be present on any of said phenyl rings.
Heater (110, 120, 130) for vehicles having an internal combustion engine, comprising a heater block with at least four rows of flow channels (2a, 2b, 3a, 3b) for a coolant to be taken from the cooling circuit of the internal combustion engine, wherein the rows of flow channels (2a, 2b, 3a, 3b) extend in the direction of the width of the heater, having at least one coolant tank (114, 124, 134, 115) for the inlet and possibly the outlet of the coolant, wherein longitudinal and transverse separating walls for redirecting the coolant in the depth and the width are arranged in at least one coolant tank (114, 124, 134) and wherein air flows through the heater block in the flow direction which corresponds to the depth direction and the coolant is guided through the flow channels (2a, 2b, 3a, 3b) in counter-flow, characterised in that the coolant is distributed to a number of flow channels (2a, 2b) at the inlet side of at least one coolant tank (114, 124, 134) at the inlet side corresponding to the number of flow channels of one row maximum and the coolant is distributed to two rows of channels (2a, 2b), wherein two respective adjacent flow channels (2a, 2b, 3a, 3b) are formed as two-chamber flat tubes (2, 3), wherein the coolant at the inlet side is redirected at least once in the width and at least one transverse separating wall is arranged in the coolant tank (114, 124, 134) at the inlet side, wherein the coolant is subsequently redirected in the depth and distributed to only one row of flow channels (3a, 3b), wherein afterwards a second redirection of the coolant in the depth occurs.
A process for preparing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group of ammonia, primary and secondary amines, in the presence of a supported copper-, nickel- and cobalt-containing catalyst, wherein the catalytically active material of the catalyst, before the reduction thereof with hydrogen, comprises oxygen compounds of aluminum, of copper, of nickel and of cobalt, and in the range from 0.2 to 5.0% by weight of oxygen compounds of tin, calculated as SnO.
A random access method, comprising: receiving, by a target eNB, a handover request message from a source eNB; wherein the handover request message includes user equipment's, UE's, capability information about target component carriers being supported and information of target component carriers selected by the source eNB; determining, by the target eNB, whether the target component carriers selected by the source eNB are allowed; wherein the target component carriers include an uplink and/or a downlink component carrier; if the target component carriers selected by the source eNB are allowed, notifying, by the target eNB, the UE of information about the target component carriers through the source eNB; wherein the notifying step comprises notifying, by the target eNB, the source eNB of the information about the target component carriers through a handover request acknowledgement message in response to which the information about the target component carriers is sent to the UE from the source eNB through a handover command; receiving, by the target eNB, a dedicated random access preamble from the UE; sending, by the target eNB, a random access response message on a component carrier in the target component carriers; receiving, by the target eNB, a radio resource control connection reconfiguration complete message from the UE. receiving, by a target eNB, a handover request message from a source eNB; wherein the handover request message includes user equipment's, UE's, capability information about target component carriers being supported and information of target component carriers selected by the source eNB; determining, by the target eNB, whether the target component carriers selected by the source eNB are allowed; wherein the target component carriers include an uplink and/or a downlink component carrier; if the target component carriers selected by the source eNB are allowed, notifying, by the target eNB, the UE of information about the target component carriers through the source eNB; wherein the notifying step comprises notifying, by the target eNB, the source eNB of the information about the target component carriers through a handover request acknowledgement message in response to which the information about the target component carriers is sent to the UE from the source eNB through a handover command; receiving, by the target eNB, a dedicated random access preamble from the UE; sending, by the target eNB, a random access response message on a component carrier in the target component carriers; receiving, by the target eNB, a radio resource control connection reconfiguration complete message from the UE.
A balloon catheter comprising: a balloon; and a cylindrical outer shaft to which at least a part of the balloon is attached, the outer shaft forming an inflation lumen through which fluid for inflating the balloon is supplied; an opening control portion provided in the outer shaft and having a control hole (36b, 336b, 436b) that communicates with the inflation lumen; and a core wire formed of a long wire disposed in the outer shaft, characterized by: the core wire including a pushing portion (72,172) that is capable of coming into contact with and of being removed from the control hole (36b, 336b, 436b) in the opening control portion. a balloon; and a cylindrical outer shaft to which at least a part of the balloon is attached, the outer shaft forming an inflation lumen through which fluid for inflating the balloon is supplied; an opening control portion provided in the outer shaft and having a control hole (36b, 336b, 436b) that communicates with the inflation lumen; and a core wire formed of a long wire disposed in the outer shaft, characterized by: the core wire including a pushing portion (72,172) that is capable of coming into contact with and of being removed from the control hole (36b, 336b, 436b) in the opening control portion.
A terminal comprising: an address book configured to store data associated with one or more contact persons; one or more application programs capable of running on the terminal; a program determining unit configured to determine, for a designated contact person in the address book, at least one of the one or more application programs that is associated with the designated contact person; and characterised by comprising: a displaying unit configured to simultaneously display: a head portrait of the designated contact person from the address book, and a head portrait of the designated contact person for each of the application programs that is associated with the designated contact person, wherein each head portrait of the designated contact person for each of the application programs that is associated with the designated contact person is selectable, and wherein the terminal is operable, via the displaying unit, to set the head portrait of the designated contact person for each of the application programs. an address book configured to store data associated with one or more contact persons; one or more application programs capable of running on the terminal; a program determining unit configured to determine, for a designated contact person in the address book, at least one of the one or more application programs that is associated with the designated contact person; and characterised by comprising: a displaying unit configured to simultaneously display: a head portrait of the designated contact person from the address book, and a head portrait of the designated contact person for each of the application programs that is associated with the designated contact person, wherein each head portrait of the designated contact person for each of the application programs that is associated with the designated contact person is selectable, and wherein the terminal is operable, via the displaying unit, to set the head portrait of the designated contact person for each of the application programs. a displaying unit configured to simultaneously display: a head portrait of the designated contact person from the address book, and a head portrait of the designated contact person for each of the application programs that is associated with the designated contact person, a head portrait of the designated contact person from the address book, and a head portrait of the designated contact person for each of the application programs that is associated with the designated contact person, wherein each head portrait of the designated contact person for each of the application programs that is associated with the designated contact person is selectable, and wherein the terminal is operable, via the displaying unit, to set the head portrait of the designated contact person for each of the application programs.
Accessory (100; 100'; 100"; 1000) for a trunking which is intended to establish a continuation between at least two joined end to end trunking cover portions, said accessory (100; 100'; 100"; 1000) having an inner face (102; 102'; 102"; 1002) which is capable of covering the two cover portions in part, characterised in that said inner face (102; 102'; 102"; 1002) is subdivided into at least two zones (102A, 102B; 102'A, 102'B; 102"A, 102"B; 1002A, 1002B), namely at least one first zone (102A; 102'A; 102"A; 1002A) which is provided with an adhesive material (103; 103'; 103"; 1003) and is capable of being applied against one of said cover portions, and a second zone (102B; 102'B; 102"B; 1002B) which is completely free of adhesive material and is capable of being applied against at least the other of said cover portions, in such a way that said accessory (100; 100'; 100"; 1000) is capable of being fixed by adhesion exclusively onto one of said cover portions.
A therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds programmed death 1 (PD-1) for use in a method of treating or inhibiting the growth of a MUC16-expressing tumor in combination with a therapeutically effective amount of a bispecific antibody comprising a first antigen-binding arm that specifically binds MUC16 and a second antigen-binding arm that specifically binds CD3, said method comprising administering to a subject in need thereof the antibody or antigen-binding fragment thereof that specifically binds PD-1 and the bispecific antibody, wherein: (a) the anti-PD-1 antibody or antigen-binding fragment thereof comprises three heavy chain complementarity determining regions, HCDR1, HCDR2, HCDR3, and three light chain complementarity determining regions, LCDR1, LCDR2, and LCDR3, wherein HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 comprise the amino acid sequences of SEQ ID NOs: 35, 36, 37, 38, 39, and 40, respectively; (b) the first antigen-binding arm of the bispecific antibody comprises three heavy chain complementarity determining regions, A-HCDR1, A-HCDR2 and A-HCDR3, and three light chain complementarity determining regions, A-LCDR1, A-LCDR2 and A-LCDR3, wherein A-HCDR1, A-HCDR2, A-HCDR3, A-LCDR1, A-LCDR2, and A-LCDR3 comprise the amino acid sequences of SEQ ID NOs: 8, 9, 10, 11, 12 and 13, respectively; and (c) the second antigen-binding arm of the bispecific antibody comprises three heavy chain complementarity determining regions, B-HCDR1, B-HCDR2 and B-HCDR3, and three light chain complementarity determining regions, B-LCDR1, B-LCDR2 and B-LCDR3, wherein B-HCDR1, B-HCDR2, B-HCDR3, B-LCDR1, B-LCDR2, and B-LCDR3 comprise the amino acid sequences of SEQ ID NOs: 14, 15, 16, 11, 12, and 13, respectively, or SEQ ID NOs: 26, 27, 28, 11, 12, and 13, respectively. (a) the anti-PD-1 antibody or antigen-binding fragment thereof comprises three heavy chain complementarity determining regions, HCDR1, HCDR2, HCDR3, and three light chain complementarity determining regions, LCDR1, LCDR2, and LCDR3, wherein HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 comprise the amino acid sequences of SEQ ID NOs: 35, 36, 37, 38, 39, and 40, respectively; (b) the first antigen-binding arm of the bispecific antibody comprises three heavy chain complementarity determining regions, A-HCDR1, A-HCDR2 and A-HCDR3, and three light chain complementarity determining regions, A-LCDR1, A-LCDR2 and A-LCDR3, wherein A-HCDR1, A-HCDR2, A-HCDR3, A-LCDR1, A-LCDR2, and A-LCDR3 comprise the amino acid sequences of SEQ ID NOs: 8, 9, 10, 11, 12 and 13, respectively; and (c) the second antigen-binding arm of the bispecific antibody comprises three heavy chain complementarity determining regions, B-HCDR1, B-HCDR2 and B-HCDR3, and three light chain complementarity determining regions, B-LCDR1, B-LCDR2 and B-LCDR3, wherein B-HCDR1, B-HCDR2, B-HCDR3, B-LCDR1, B-LCDR2, and B-LCDR3 comprise the amino acid sequences of SEQ ID NOs: 14, 15, 16, 11, 12, and 13, respectively, or SEQ ID NOs: 26, 27, 28, 11, 12, and 13, respectively.
A method implemented by a network service provider in a network, wherein the network contains network devices, wherein traffic flows transmit through a number of network devices of the network, the method comprising: dividing traffic flows of the network into a plurality of traffic aggregates, wherein each traffic aggregate contains one or more traffic flows, and wherein each traffic aggregate is an entry of a first set for monitoring; and for each entry of the first set, collecting a second set of one or more network devices from the network devices of the network to monitor the entry, wherein the second set comprises one or more network devices that the traffic flows contained within the entry flow through; and selecting one network device from the second set of one or more network devices to monitor the entry for a traffic anomaly, wherein the selection is at least partially based on a monitor count of the network device, wherein the monitor count of the network device is a count of a number of entries of the first set that the network device is currently monitoring. dividing traffic flows of the network into a plurality of traffic aggregates, wherein each traffic aggregate contains one or more traffic flows, and wherein each traffic aggregate is an entry of a first set for monitoring; and for each entry of the first set, collecting a second set of one or more network devices from the network devices of the network to monitor the entry, wherein the second set comprises one or more network devices that the traffic flows contained within the entry flow through; and selecting one network device from the second set of one or more network devices to monitor the entry for a traffic anomaly, wherein the selection is at least partially based on a monitor count of the network device, wherein the monitor count of the network device is a count of a number of entries of the first set that the network device is currently monitoring. collecting a second set of one or more network devices from the network devices of the network to monitor the entry, wherein the second set comprises one or more network devices that the traffic flows contained within the entry flow through; and selecting one network device from the second set of one or more network devices to monitor the entry for a traffic anomaly, wherein the selection is at least partially based on a monitor count of the network device, wherein the monitor count of the network device is a count of a number of entries of the first set that the network device is currently monitoring.
A method of wireless communication, comprising: transmitting a first set of information in a first peer discovery signal with a first periodicity and a first peer discovery range; generating an identifier based on the first set of information, wherein the identifier is transmitted with a second set of information and wherein the identifier is a hash value generated based on a hash function applied to the first set of information; and transmitting the second set of information in a second peer discovery signal with a second periodicity and a second peer discovery range, the second periodicity being different from the first periodicity, the second peer discovery range being less than the first peer discovery range, the second set of information being associated with the first set of information. transmitting a first set of information in a first peer discovery signal with a first periodicity and a first peer discovery range; generating an identifier based on the first set of information, wherein the identifier is transmitted with a second set of information and wherein the identifier is a hash value generated based on a hash function applied to the first set of information; and transmitting the second set of information in a second peer discovery signal with a second periodicity and a second peer discovery range, the second periodicity being different from the first periodicity, the second peer discovery range being less than the first peer discovery range, the second set of information being associated with the first set of information.
A composition for use in treating dysphoria, depression and/or mood swings relating to premenstrual syndrome wherein said composition comprises as first active ingredient: - a pollen and pistil extract derived from plants belonging to the Graminae and/or Pinacea family, preferably from plant material originating from corn ( Zea mays L)., rye ( Secale cereale L.), cocksfoot ( Dactylis glomerata L.), pine ( Pinus sylvestris L.) or a mixture thereof, - at least one second active ingredient, being a source of safranal and/or (picro)crocin wherein said source of safranal and/or (picro)crocin is saffron or a derivative of saffron, and - vitamin E. - a pollen and pistil extract derived from plants belonging to the Graminae and/or Pinacea family, preferably from plant material originating from corn ( Zea mays L)., rye ( Secale cereale L.), cocksfoot ( Dactylis glomerata L.), pine ( Pinus sylvestris L.) or a mixture thereof, - at least one second active ingredient, being a source of safranal and/or (picro)crocin wherein said source of safranal and/or (picro)crocin is saffron or a derivative of saffron, and - vitamin E.
An apparatus comprising: (a) a body; (b) a shaft assembly extending distally from the body, wherein the shaft assembly has a distal end; (c) an end effector at the distal end of the shaft assembly, wherein the end effector is operable to operate on tissue; (d) an activation circuit, wherein the activation circuit comprises: (i) an end effector driver, wherein the end effector driver is operable to drive the end effector to perform an operation on tissue, and (ii) a driver activation switch, wherein the driver activation switch is configured to transition between an open state and a closed state; and (e) a user input feature operable to transition between a non-actuated state and an actuated state, characterized in that the end effector driver is configured to activate in response to the driver activation switch transitioning to the open state, wherein the end effector driver is configured to not activate in response to the driver activation switch being in the closed state, and wherein the driver activation switch is configured to remain in the closed state when the user input feature is in the non-actuated state, wherein the driver activation switch is configured to transition from the closed state to the open state in response to the user input feature transitioning from the non-actuated state to the actuated state. (a) a body; (b) a shaft assembly extending distally from the body, wherein the shaft assembly has a distal end; (c) an end effector at the distal end of the shaft assembly, wherein the end effector is operable to operate on tissue; (d) an activation circuit, wherein the activation circuit comprises: (i) an end effector driver, wherein the end effector driver is operable to drive the end effector to perform an operation on tissue, and (ii) a driver activation switch, wherein the driver activation switch is configured to transition between an open state and a closed state; and (i) an end effector driver, wherein the end effector driver is operable to drive the end effector to perform an operation on tissue, and (ii) a driver activation switch, wherein the driver activation switch is configured to transition between an open state and a closed state; and (e) a user input feature operable to transition between a non-actuated state and an actuated state, characterized in that the end effector driver is configured to activate in response to the driver activation switch transitioning to the open state, wherein the end effector driver is configured to not activate in response to the driver activation switch being in the closed state, and wherein the driver activation switch is configured to remain in the closed state when the user input feature is in the non-actuated state, wherein the driver activation switch is configured to transition from the closed state to the open state in response to the user input feature transitioning from the non-actuated state to the actuated state.