A compound represented by Formula wherein R 1 is a phenyl group optionally substituted with one or more substituents independently selected from halogen, straight-chained or branched haloC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy groups; a furanyl or thiophenyl group; R 2 and R 3 are independently hydrogen or C 1-6 alkyl group; R 4 is C 1-6 alkyl group substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; and R 5 is hydrogen, C 1-6 alkyl group optionally substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; or R 4 is hydrogen, C 1-6 alkyl group optionally substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; and R 5 is C 1-6 alkyl group substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; R 6 is C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-6 alkyl or arylC 1-6 alkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters thereof for use as smart drug in the therapeutic or prophylactic treatment of a heat shock protein modulated disorder selected from the group consisting of neurodegenerative diseases, cancerous diseases, metabolic syndromes, lysosomal storage diseases and skin disorder conditions by selective interactions with only those cells which are under stress. R 1 is a phenyl group optionally substituted with one or more substituents independently selected from halogen, straight-chained or branched haloC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy groups; a furanyl or thiophenyl group; R 2 and R 3 are independently hydrogen or C 1-6 alkyl group; R 4 is C 1-6 alkyl group substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; and R 5 is hydrogen, C 1-6 alkyl group optionally substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; or R 4 is hydrogen, C 1-6 alkyl group optionally substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; and R 5 is C 1-6 alkyl group substituted with amino, mono- or di(C 1-6 alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C 1-6 alkyl or C 1-6 alkoxy; R 6 is C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-6 alkyl or arylC 1-6 alkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters thereof for use as smart drug in the therapeutic or prophylactic treatment of a heat shock protein modulated disorder selected from the group consisting of neurodegenerative diseases, cancerous diseases, metabolic syndromes, lysosomal storage diseases and skin disorder conditions by selective interactions with only those cells which are under stress.