A compound of formula: R 1 is selected from: a group of the following formula: wherein P is aryl which is unsubstituted or substituted; Q is selected from -H, -OR, -SR, -Halo, -NR 3 R 4, -OS m R, -OC R, -OC NHR, -S m NR 3 R 4, -NRC R, -NRS m R, -NRC NR 3 R 4, and -NRC NR 3 R 4, wherein each R, R 3, and R 4 is independently selected from H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl and a 5- to 12-membered carbocyclic group, aryl or heteroaryl group, the group being unsubstituted or substituted; m is 1 or 2; or R 3 and R 4, which are the same or different, are each independently selected from H, C 1 -C 6 alkyl which is unsubstituted or substituted, C 3 -C 10 cycloalkyl which is unsubstituted or substituted, -C R, -C N 2 and -S m R wherein R and m are as defined above, or R 3 and R 4 together with the nitrogen atom to which they are attached form a saturated 5-, 6- or 7-membered N-containing heterocyclic group which is unsubstituted or substituted; Y is selected from -O-(CH 2) n -, -S-(CH 2) n -, and -S m (CH 2) n - wherein m is 1 or 2, n is an integer of 1 to 3, and R 2 is selected from H or a 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted, and a group -NR 3 R 4 wherein R 3 and R 4 are as defined above; Z is selected from (i) halo, -(CH 2) s COOR, -(CH 2) 5 CHO, -(CH 2) s CH 2 OR, - (CH 2) s CONR 3 R 4, -(CH 2) 5 CH 2 NR 3 R 4, -NR 3 R a and -O(CH 2) s NR 3 R 4 wherein s is 0 or an integer of 1 to 2 and wherein R, R 3 and R 4 are as defined above; (ii) substituted or unsubstituted heteroaryl, (iii) substituted or unsubstituted heterocyclyl, (iv) substituted or unsubstituted aryl, and (v) substituted or unsubstituted C 1 -C 6 -alkyl; and W is selected from NR 5 R 6, wherein R 5 and R 6 form, together with the N atom to which they are attached, a morpholine ring which is unsubstituted or substituted; or a stereoisomer, or a tautomer, or an N-oxide, or a pharmaceutically acceptable salt, or an ester, or a hydrate, or a solvate thereof. a group of the following formula: wherein P is aryl which is unsubstituted or substituted; Q is selected from -H, -OR, -SR, -Halo, -NR 3 R 4, -OS m R, -OC R, -OC NHR, -S m NR 3 R 4, -NRC R, -NRS m R, -NRC NR 3 R 4, and -NRC NR 3 R 4, wherein each R, R 3, and R 4 is independently selected from H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl and a 5- to 12-membered carbocyclic group, aryl or heteroaryl group, the group being unsubstituted or substituted; m is 1 or 2; or R 3 and R 4, which are the same or different, are each independently selected from H, C 1 -C 6 alkyl which is unsubstituted or substituted, C 3 -C 10 cycloalkyl which is unsubstituted or substituted, -C R, -C N 2 and -S m R wherein R and m are as defined above, or R 3 and R 4 together with the nitrogen atom to which they are attached form a saturated 5-, 6- or 7-membered N-containing heterocyclic group which is unsubstituted or substituted; Y is selected from -O-(CH 2) n -, -S-(CH 2) n -, and -S m (CH 2) n - wherein m is 1 or 2, n is an integer of 1 to 3, and R 2 is selected from H or a 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted, and a group -NR 3 R 4 wherein R 3 and R 4 are as defined above; Z is selected from (i) halo, -(CH 2) s COOR, -(CH 2) 5 CHO, -(CH 2) s CH 2 OR, - (CH 2) s CONR 3 R 4, -(CH 2) 5 CH 2 NR 3 R 4, -NR 3 R a and -O(CH 2) s NR 3 R 4 wherein s is 0 or an integer of 1 to 2 and wherein R, R 3 and R 4 are as defined above; (ii) substituted or unsubstituted heteroaryl, (iii) substituted or unsubstituted heterocyclyl, (iv) substituted or unsubstituted aryl, and (v) substituted or unsubstituted C 1 -C 6 -alkyl; and W is selected from NR 5 R 6, wherein R 5 and R 6 form, together with the N atom to which they are attached, a morpholine ring which is unsubstituted or substituted;