A compound of Formula: wherein: A is phenyl or benzofuranyl, wherein phenyl and benzofuranyl are each optionally substituted with at least one R; or A is phenyl substituted with two R groups on adjacent carbon atoms wherein the two R groups and the carbon atoms to which they are attached form a C 4 -C 8 cycloalkyl or C 3 -Csheterocycloalkyl; R is selected from F, Cl, Br, I, -CN, -NO 2, -CF 3, -OH, -OR 3, -OCF 3, -C≡CH, -C≡CR 3, C 1 -C 6 alkylenealkynyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 6 heterocycloalkyl, phenyl, -NHS(=O) 2 R 3, S(=O) 2 N(R 4) 2, -C(=O)CF 3, -C(=O)NHS(=O) 2 R 3, - S(=O) 2 NHC(=O)R 4, N(R 4) 2, -N(R 4)C(=O)R 3, -CO 2 R 4, -C(=O)R 3, -OC(=O)R 3, -C(=O)N(R 4) 2, -SR 3, - S(=O)R 3, and -S(=O) 2 R 3; J is a bond, R 1 is CO 2 R 2, wherein R 2 is hydrogen; Z is O; X is B, optionally substituted with at least one R; B is selected from thiophene, pyrrole, pyridine, oxazole, thiazole, imidazole, thiadiazole, isoxazole, isothiazole, pyrazole, pyridazine, pyrimidine, pyrazine, oxadiazole, thiadiazole, triazole, indole, benzoxazole, benzothiazole, benzimidazole, benzoxadiazole, benzothiadiazole, benzotriazole, pyrazolopyridine, imidazopyridine, pyrrolopyridine, pyrrolopyrimidine, indolizine, purine, furopyridine, thienopyridine, furopyrrole, furofuran, thienofuran, 1,4-dihydropyrrolopyrrole, thienopyrrole, thienothiophene, quinoline, isoquinoline, furopyrazole, thienopyrazole, and 1,6-dihydropyrrolopyrazole; each R 3 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; R 4 is hydrogen; or a pharmaceutically acceptable salt thereof. A is phenyl or benzofuranyl, wherein phenyl and benzofuranyl are each optionally substituted with at least one R; or A is phenyl substituted with two R groups on adjacent carbon atoms wherein the two R groups and the carbon atoms to which they are attached form a C 4 -C 8 cycloalkyl or C 3 -Csheterocycloalkyl; R is selected from F, Cl, Br, I, -CN, -NO 2, -CF 3, -OH, -OR 3, -OCF 3, -C≡CH, -C≡CR 3, C 1 -C 6 alkylenealkynyl, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, tetrazolyl, C 2 -C 6 heterocycloalkyl, phenyl, -NHS(=O) 2 R 3, S(=O) 2 N(R 4) 2, -C(=O)CF 3, -C(=O)NHS(=O) 2 R 3, - S(=O) 2 NHC(=O)R 4, N(R 4) 2, -N(R 4)C(=O)R 3, -CO 2 R 4, -C(=O)R 3, -OC(=O)R 3, -C(=O)N(R 4) 2, -SR 3, - S(=O)R 3, and -S(=O) 2 R 3; J is a bond, R 1 is CO 2 R 2, wherein R 2 is hydrogen; Z is O; X is B, optionally substituted with at least one R; B is selected from thiophene, pyrrole, pyridine, oxazole, thiazole, imidazole, thiadiazole, isoxazole, isothiazole, pyrazole, pyridazine, pyrimidine, pyrazine, oxadiazole, thiadiazole, triazole, indole, benzoxazole, benzothiazole, benzimidazole, benzoxadiazole, benzothiadiazole, benzotriazole, pyrazolopyridine, imidazopyridine, pyrrolopyridine, pyrrolopyrimidine, indolizine, purine, furopyridine, thienopyridine, furopyrrole, furofuran, thienofuran, 1,4-dihydropyrrolopyrrole, thienopyrrole, thienothiophene, quinoline, isoquinoline, furopyrazole, thienopyrazole, and 1,6-dihydropyrrolopyrazole; each R 3 is independently selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; R 4 is hydrogen; or