A method comprising: generating, by one or more processors and for display at a user interface, a representation of an anatomical region of a patient; generating, by the one or more processors and for display at the user interface, a representation of one or more atlas-defined anatomical structures at a first position over the representation of the anatomical region of the patient; receiving, by the one or more processors, a user annotation that defines an adjustment to at least one atlas-defined anatomical structure of the one or more atlas-defined anatomical structures relative to the representation of the anatomical region of the patient; determining, by the one or more processors and based on the adjustment defined by the user annotation, one or more adjustments of the representation of the one or more atlas-defined anatomical structures by one or more movement amounts; selecting, by the one or more processors, one of the one or more adjustments that decreases a distance between the representation of the one or more atlas-defined anatomical structures and the annotation by a greatest amount; performing, by the one or more processors, the one of the one or more adjustments that decreases the distance between the representation of the one or more atlas-defined anatomical structures and the annotation by the greatest amount to move the representation of the one or more atlas-defined anatomical structures to a second position over the representation of the anatomical region of the patient; and controlling, by the one or more processors, the user interface to display the representation of the one or more atlas-defined anatomical structures at the second position over the representation of the anatomical region of the patient. generating, by one or more processors and for display at a user interface, a representation of an anatomical region of a patient; generating, by the one or more processors and for display at the user interface, a representation of one or more atlas-defined anatomical structures at a first position over the representation of the anatomical region of the patient; receiving, by the one or more processors, a user annotation that defines an adjustment to at least one atlas-defined anatomical structure of the one or more atlas-defined anatomical structures relative to the representation of the anatomical region of the patient; determining, by the one or more processors and based on the adjustment defined by the user annotation, one or more adjustments of the representation of the one or more atlas-defined anatomical structures by one or more movement amounts; selecting, by the one or more processors, one of the one or more adjustments that decreases a distance between the representation of the one or more atlas-defined anatomical structures and the annotation by a greatest amount; performing, by the one or more processors, the one of the one or more adjustments that decreases the distance between the representation of the one or more atlas-defined anatomical structures and the annotation by the greatest amount to move the representation of the one or more atlas-defined anatomical structures to a second position over the representation of the anatomical region of the patient; and controlling, by the one or more processors, the user interface to display the representation of the one or more atlas-defined anatomical structures at the second position over the representation of the anatomical region of the patient.