A compound selected from the group consisting of: -9-fluoro-15-hydroxy-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26] hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R,15 R)-9-fluoro-15-hydroxy-13-oxa-2,11,17,21,22,25-hexaazapentacyclo-[17.5.2.0 2,6.0 7,12.0 22,26]hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-13-oxa-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-13-oxa-2,11,18,22,23,26-hexaazapentacyclo[18.5,2.0 2,6.0 7,12.0 23,27]heptacosa-1,7,9,11,20,21,24-heptaen-19-one; -9-fluoro-2,11,13,16,20,21,24-heptaazapentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-2,11,13,17,21,22,25-heptaazapentacyclo[17.5.2.0 2,6.0 7,12 0 22,26]hexacosa 1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-17-methyl-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26] hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9,15,15-trifluoro-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26]hexa-cosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,1.0 1,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,6.0 7,12.02 1,25]pentacosa-l,7,9,11,18, 19,22-heptaen-17-one; (6 R)-9-fluoro-15,15-dimethyl-13-oxa-2,11,17,21,22,25-hexaaza-pentacyclo[17.5.2.0 2,6.0 7,12.0 22,26]hexacosa-1,7,9,11,19,20,23-heptaen-18-one; and (6 R)-9-fluoro-15,15-dimethyl-2,11,16,20,21,24-hexaaza-pentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; or a pharmaceutically acceptable salt thereof. -9-fluoro-15-hydroxy-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26] hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R,15 R)-9-fluoro-15-hydroxy-13-oxa-2,11,17,21,22,25-hexaazapentacyclo-[17.5.2.0 2,6.0 7,12.0 22,26]hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-13-oxa-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-13-oxa-2,11,18,22,23,26-hexaazapentacyclo[18.5,2.0 2,6.0 7,12.0 23,27]heptacosa-1,7,9,11,20,21,24-heptaen-19-one; -9-fluoro-2,11,13,16,20,21,24-heptaazapentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-2,11,13,17,21,22,25-heptaazapentacyclo[17.5.2.0 2,6.0 7,12 0 22,26]hexacosa 1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-17-methyl-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26] hexacosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9,15,15-trifluoro-13-oxa-2,11,17,21,22,25-hexaazapentacyclo[17.5.2.0 2,6.0 7,12.0 22,26]hexa-cosa-1,7,9,11,19,20,23-heptaen-18-one; (6 R)-9-fluoro-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,1.0 1,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one; (6 R)-9-fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.0 2,6.0 7,12.02 1,25]pentacosa-l,7,9,11,18, 19,22-heptaen-17-one; (6 R)-9-fluoro-15,15-dimethyl-13-oxa-2,11,17,21,22,25-hexaaza-pentacyclo[17.5.2.0 2,6.0 7,12.0 22,26]hexacosa-1,7,9,11,19,20,23-heptaen-18-one; and (6 R)-9-fluoro-15,15-dimethyl-2,11,16,20,21,24-hexaaza-pentacyclo[16.5.2.0 2,6.0 7,12.0 21,25]pentacosa-1,7,9,11,18,19,22-heptaen-17-one;