A pulse laser system configured for treatment of an eye, the system comprising: a diode pump source; a frequency doubled cw solid state visible laser configured to be pumped by the diode pump source, the frequency doubled cw solid state visible laser being operable to produce a pulsed laser output, wherein the pulsed laser output has a wavelength in a visible range from 520 nm to 615 nm; a photodetector configured to monitor the laser output before it is delivered to a target site, wherein the target site is eye tissue; and a feedback control system having a hardware light loop and a software light loop each connected to the diode pump source, the feedback control system being configured to be responsive to a signal from the photodetector and to repeatedly compare the photodetector signal to a target pulse power on a microsecond time scale throughout the duration of each pulse of the frequency doubled solid state laser so as to control power fluctuations of each pulse of the frequency doubled solid state laser to within less than 10% of the target pulse power level, said feedback control system further being configured to use a comparison of the photodetector signal to the target pulse power level to determine pulse on and off times and to create the pulsed laser output with a train of pulses with pulse on and off times that provide for photoactivation in the eye tissue of the target site, wherein the pulsed laser output has a pulse train of up to 500 pulses with a variable duty factor from 5 to 25%, pulse on times of 25 microseconds to 10,000 microseconds, and a power level up to 3 Watts, and wherein the train of pulses are configured to confine the thermal effect to the retinal pigment epithelium, RPE, without affecting the neurosensory retina of the eye. a diode pump source; a frequency doubled cw solid state visible laser configured to be pumped by the diode pump source, the frequency doubled cw solid state visible laser being operable to produce a pulsed laser output, wherein the pulsed laser output has a wavelength in a visible range from 520 nm to 615 nm; a photodetector configured to monitor the laser output before it is delivered to a target site, wherein the target site is eye tissue; and a feedback control system having a hardware light loop and a software light loop each connected to the diode pump source, the feedback control system being configured to be responsive to a signal from the photodetector and to repeatedly compare the photodetector signal to a target pulse power on a microsecond time scale throughout the duration of each pulse of the frequency doubled solid state laser so as to control power fluctuations of each pulse of the frequency doubled solid state laser to within less than 10% of the target pulse power level, said feedback control system further being configured to use a comparison of the photodetector signal to the target pulse power level to determine pulse on and off times and to create the pulsed laser output with a train of pulses with pulse on and off times that provide for photoactivation in the eye tissue of the target site, wherein the pulsed laser output has a pulse train of up to 500 pulses with a variable duty factor from 5 to 25%, pulse on times of 25 microseconds to 10,000 microseconds, and a power level up to 3 Watts, and wherein the train of pulses are configured to confine the thermal effect to the retinal pigment epithelium, RPE, without affecting the neurosensory retina of the eye.