A composition consisting of an effective amount of an isolated anti-microbial adhesion inhibitory fraction A6 from cranberry as an active ingredient wherein said isolated fraction has an acetylated, neutral sugar-rich polysaccharide having a weight average molar mass of approximately 10.2 X 10 3 ± 2.0 Da, a Z-average hydrodynamic radius of approximately 2.0 ± 0.2 nm, a weight-average intrinsic viscosity of approximately 0.048 ± 0.0001 dL/g, has been prepared by a process comprising the steps of: (a) providing cranberry hulls, (b) treating said cranberry hulls with a pectinase equivalent to the family of Klerzyme 150 pectinase in amounts sufficient to depectinize said hulls to form an enzyme treated composition, (c) removing debris from said enzyme treated composition using a method such as decantation or centrifugation, to form a first liquid, (d) spray drying said first liquid to form a composition A1, (e) dissolving the composition A1 with deionized water and loading it to a column from a Biotage FLASH-40 chromatographic system, converted to accept Biotage SNAP KP-C18-HS 120 g cartridges, fitted with a SNAP KP-C18-HS 12 g samples, pre-conditioned with methanol and water, (f) fractionating said composition A1 by eluting column first with deionized water following with a methanol/water mixture to produce composition A2, (g) repeating step (f) 4 times, (h) freeze drying said composition A2 by first removing the methanol under vacuum, (i) analyzing the peak observed in the A2 fraction that eluted at approximately 6.7 min from a HPX-87C HPLC column using refractive index detection, (j) purifying composition A2 using LH20 gel column chromatography by first dissolving the fraction in deionized water to produce said anti-microbial adhesion inhibitory fraction A6 after the elution of the column with deionized water using a Masterflex L/S pump - model 7014-52 at a flow rate of about 2.5 ml/min, (k) freeze drying said anti-microbial adhesion inhibitory fraction A6 to produce a crystalline powder, (l) mixing said crystalline powder with a carrier to provide an anti-microbial adhesion inhibitory composition. (a) providing cranberry hulls, (b) treating said cranberry hulls with a pectinase equivalent to the family of Klerzyme 150 pectinase in amounts sufficient to depectinize said hulls to form an enzyme treated composition, (c) removing debris from said enzyme treated composition using a method such as decantation or centrifugation, to form a first liquid, (d) spray drying said first liquid to form a composition A1, (e) dissolving the composition A1 with deionized water and loading it to a column from a Biotage FLASH-40 chromatographic system, converted to accept Biotage SNAP KP-C18-HS 120 g cartridges, fitted with a SNAP KP-C18-HS 12 g samples, pre-conditioned with methanol and water, (f) fractionating said composition A1 by eluting column first with deionized water following with a methanol/water mixture to produce composition A2, (g) repeating step (f) 4 times, (h) freeze drying said composition A2 by first removing the methanol under vacuum, (i) analyzing the peak observed in the A2 fraction that eluted at approximately 6.7 min from a HPX-87C HPLC column using refractive index detection, (j) purifying composition A2 using LH20 gel column chromatography by first dissolving the fraction in deionized water to produce said anti-microbial adhesion inhibitory fraction A6 after the elution of the column with deionized water using a Masterflex L/S pump - model 7014-52 at a flow rate of about 2.5 ml/min, (k) freeze drying said anti-microbial adhesion inhibitory fraction A6 to produce a crystalline powder, (l) mixing said crystalline powder with a carrier to provide an anti-microbial adhesion inhibitory composition.