A vehicle door structure comprising: a door outer panel including a projected section that is projected outward in a vehicle width direction, a recessed section that is separated from the projected section and formed to be recessed inward in the vehicle width direction, and a boundary section (α) between the projected section and the recessed section; and a panel reinforcement that is fixed to an inner surface in the vehicle width direction of the door outer panel, wherein the panel reinforcement includes: a first frame section that extends in a vehicle front-rear direction; and a second frame section that is provided at a position that overlaps with the boundary section (α) in the vehicle side view and is configured to be able to transit a load to the first frame section at the time when the load in an inward direction of the vehicle width direction is applied to the boundary section (α), characterized in that the second frame section includes: a front-rear frame section at a height position where the door outer handle is provided, the front-rear frame section extending in the vehicle front-rear direction in a manner capable of transmitting the load; and at least one up-down frame section (34 to 36) that couples the first frame section and the front-rear frame section in an up-down direction, the second frame section includes at least one truss section (T1 to T3) that is configured in a truss shape by the front-rear frame section and the at least one up-down frame section (34 to 36), and the apex of at least one of the truss sections (T1 to T3) is provided on a vehicle front-rear imaginary line (γ) that connects a front end and a rear end of the door outer handle and extends to the front of a vehicle. a door outer panel including a projected section that is projected outward in a vehicle width direction, a recessed section that is separated from the projected section and formed to be recessed inward in the vehicle width direction, and a boundary section (α) between the projected section and the recessed section; and a projected section that is projected outward in a vehicle width direction, a recessed section that is separated from the projected section and formed to be recessed inward in the vehicle width direction, and a boundary section (α) between the projected section and the recessed section; and a panel reinforcement that is fixed to an inner surface in the vehicle width direction of the door outer panel, wherein the panel reinforcement includes: a first frame section that extends in a vehicle front-rear direction; and a second frame section that is provided at a position that overlaps with the boundary section (α) in the vehicle side view and is configured to be able to transit a load to the first frame section at the time when the load in an inward direction of the vehicle width direction is applied to the boundary section (α), characterized in that the second frame section includes: a front-rear frame section at a height position where the door outer handle is provided, the front-rear frame section extending in the vehicle front-rear direction in a manner capable of transmitting the load; and at least one up-down frame section (34 to 36) that couples the first frame section and the front-rear frame section in an up-down direction, the second frame section includes at least one truss section (T1 to T3) that is configured in a truss shape by the front-rear frame section and the at least one up-down frame section (34 to 36), and the apex of at least one of the truss sections (T1 to T3) is provided on a vehicle front-rear imaginary line (γ) that connects a front end and a rear end of the door outer handle and extends to the front of a vehicle.