A compound of Formula I, a tautomer, enantiomer or pharmaceutically acceptable salt, solvate or hydrate thereof: wherein: L A is CH 2 or CH(CH 3); L B is a covalent chemical bond, OC 0-3 -alkyl, SC 0-3 - alkyl, NHC C 0-3 -alkyl, C NHC 0-3 -alkyl, C C 0-3 -alkyl, NHC 0-3 -alkyl, CH 2 O, CH 2 S, CH 2 C NH or CH 2 NH; cycle A is phenyl or a 5-6 membered heteroaryl containing 0-3 N atoms and 0-1 O or S atoms, and optionally substituted by 1-4 R A groups; R A is independently selected from halogen, partially or fully halogenated C 1-5 -alkyl, C 2-5 -alkenyl, C 2-5 -alkynyl, (CH 2) m O(CH 2) n H, (CH 2) m NH(CH 2] n H, (CH 2) m C O(CH 2) n H, (CH 2) m OC (CH 2) n H, (CH 2) m C NH(CH 2) n H, (CH 2) m NHC (CH 2) n H, CN, P (R F) 2, P 2 (R F), P 2 OH, SR E, S R E, S 2 R E or S 2 OH; cycle B is phenyl, C 3-8 cycloalkyl, 4-8-membered saturated or partially saturated heterocycle containing 0-3 N atoms, and 0-1 O or S atoms; or a 5-6 membered heteroaryl ring containing 0-3 N atoms, and 0-1 O or S atoms; ring B is optionally substituted with 1-5 R B groups; R B is independently selected from, L C -R C, L C -H, halogen, partially or completely halogenated C 1-5 -alkyl, C 2-5 -alkenyl, C 2-5 -alkynyl or CN; alternatively, two adjacent groups of R B, together with the atoms to which they are attached, may form a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring, containing 0-3 heteroatoms selected from N, O, S, S, S 2 and optionally substituted by 1-4 R C or R D substituents; L C is a covalent chemical bond, C 1-3 -alkyl, (CH 2) m O(CH 2) n, (CH 2) m NH(CH 2) n, (CH 2) m C (CH 2) n, (CH 2) m C O(CH 2) n, (CH 2) m OC (CH 2) n, (CH 2) m C NH(CH 2) n or (CH 2) m NHC (CH 2) n; R C is independently selected from phenyl, C 1-6 -alkyl, C 3-7 cycloalkyl or 3-7 membered heteroalicyclyl containing 0-3 N atoms, 0-2 O atoms and 0-2 S atoms; R C is optionally substituted by 1-5 R D or CH 2 R D substituents; R D is independently selected from halogen, (CH 2) m CH 3, (CH 2) m O(CH 2) n H, (CH 2) m C NH(CH 2) n H, (CH 2) m C (CH 2) n H, (CH 2) m NH 2, NHR F, N(R F) 2 or 3-7 membered heteroalicyclyl containing 0-3 N atoms, 0-2 O atoms, 0-2 S atoms, and optionally substituted by 1-3 R F substituents; R E is independently selected from the group consisting of C 1-3 -alkyl, NHC 1-3 -alkyl or N(C 1-3 -alkyl) 2; R F is independently selected and represents C 1-3 -alkyl; m and n are selected independently from 0, 1, 2, 3. L A is CH 2 or CH(CH 3); L B is a covalent chemical bond, OC 0-3 -alkyl, SC 0-3 - alkyl, NHC C 0-3 -alkyl, C NHC 0-3 -alkyl, C C 0-3 -alkyl, NHC 0-3 -alkyl, CH 2 O, CH 2 S, CH 2 C NH or CH 2 NH; cycle A is phenyl or a 5-6 membered heteroaryl containing 0-3 N atoms and 0-1 O or S atoms, and optionally substituted by 1-4 R A groups; R A is independently selected from halogen, partially or fully halogenated C 1-5 -alkyl, C 2-5 -alkenyl, C 2-5 -alkynyl, (CH 2) m O(CH 2) n H, (CH 2) m NH(CH 2] n H, (CH 2) m C O(CH 2) n H, (CH 2) m OC (CH 2) n H, (CH 2) m C NH(CH 2) n H, (CH 2) m NHC (CH 2) n H, CN, P (R F) 2, P 2 (R F), P 2 OH, SR E, S R E, S 2 R E or S 2 OH; cycle B is phenyl, C 3-8 cycloalkyl, 4-8-membered saturated or partially saturated heterocycle containing 0-3 N atoms, and 0-1 O or S atoms; or a 5-6 membered heteroaryl ring containing 0-3 N atoms, and 0-1 O or S atoms; ring B is optionally substituted with 1-5 R B groups; R B is independently selected from, L C -R C, L C -H, halogen, partially or completely halogenated C 1-5 -alkyl, C 2-5 -alkenyl, C 2-5 -alkynyl or CN; alternatively, two adjacent groups of R B, together with the atoms to which they are attached, may form a 5-, 6- or 7-membered saturated, partially saturated or unsaturated ring, containing 0-3 heteroatoms selected from N, O, S, S, S 2 and optionally substituted by 1-4 R C or R D substituents; L C is a covalent chemical bond, C 1-3 -alkyl, (CH 2) m O(CH 2) n, (CH 2) m NH(CH 2) n, (CH 2) m C (CH 2) n, (CH 2) m C O(CH 2) n, (CH 2) m OC (CH 2) n, (CH 2) m C NH(CH 2) n or (CH 2) m NHC (CH 2) n; R C is independently selected from phenyl, C 1-6 -alkyl, C 3-7 cycloalkyl or 3-7 membered heteroalicyclyl containing 0-3 N atoms, 0-2 O atoms and 0-2 S atoms; R C is optionally substituted by 1-5 R D or CH 2 R D substituents; R D is independently selected from halogen, (CH 2) m CH 3, (CH 2) m O(CH 2) n H, (CH 2) m C NH(CH 2) n H, (CH 2) m C (CH 2) n H, (CH 2) m NH 2, NHR F, N(R F) 2 or 3-7 membered heteroalicyclyl containing 0-3 N atoms, 0-2 O atoms, 0-2 S atoms, and optionally substituted by 1-3 R F substituents; R E is independently selected from the group consisting of C 1-3 -alkyl, NHC 1-3 -alkyl or N(C 1-3 -alkyl) 2; R F is independently selected and represents C 1-3 -alkyl; m and n are selected independently from 0, 1, 2, 3.