A method of filling gas mixture supply vessels with at least two constituent gases to achieve a gas mixture, said method comprising: providing a source vessel of a constituent first gas, and multiple target vessels to be filled with said at least two constituent gases; flowing the constituent first gas to at least one of the multiple target vessels for a period of time until a predetermined pressure is reached or until pressure stabilizes; discontinuing flow of the constituent first gas to said at least one of the multiple target vessels, comprising closing said at least one of the multiple target vessels to which constituent first gas has been flowed; repeating steps - for each of other ones of the multiple target vessels to which constituent first gas has not been introduced; closing the source vessel; optionally repeating steps - with other source vessel(s) until a predetermined target pressure of the constituent first gas is reached in said multiple target vessels, to provide constituent first gas in said multiple target vessels at said predetermined target pressure; flowing a constituent second gas to at least one of the multiple target vessels containing the constituent first gas to produce a gas mixture having relative proportions of the constituent first gas and the constituent second gas while maintaining the at least one target vessel at a predetermined temperature during introduction of the constituent second gas to the at least one target vessel; said method being characterized in that it further comprises: cooling the at least one target vessel containing the gas mixture to condense one of the constituent first gas or constituent second gas, wherein the other of the constituent first gas or constituent second gas that is not condensed remains in the gas phase; and removing the gas phase constituent first gas or constituent second gas from the at least one target vessel or introducing additional constituent first gas or constituent second gas to the at least one target vessel to adjust the relative proportions of the constituent first gas and the constituent second gas in the gas mixture to a desired value. providing a source vessel of a constituent first gas, and multiple target vessels to be filled with said at least two constituent gases; flowing the constituent first gas to at least one of the multiple target vessels for a period of time until a predetermined pressure is reached or until pressure stabilizes; discontinuing flow of the constituent first gas to said at least one of the multiple target vessels, comprising closing said at least one of the multiple target vessels to which constituent first gas has been flowed; repeating steps - for each of other ones of the multiple target vessels to which constituent first gas has not been introduced; closing the source vessel; optionally repeating steps - with other source vessel(s) until a predetermined target pressure of the constituent first gas is reached in said multiple target vessels, to provide constituent first gas in said multiple target vessels at said predetermined target pressure; flowing a constituent second gas to at least one of the multiple target vessels containing the constituent first gas to produce a gas mixture having relative proportions of the constituent first gas and the constituent second gas while maintaining the at least one target vessel at a predetermined temperature during introduction of the constituent second gas to the at least one target vessel; said method being characterized in that it further comprises: cooling the at least one target vessel containing the gas mixture to condense one of the constituent first gas or constituent second gas, wherein the other of the constituent first gas or constituent second gas that is not condensed remains in the gas phase; and removing the gas phase constituent first gas or constituent second gas from the at least one target vessel or introducing additional constituent first gas or constituent second gas to the at least one target vessel to adjust the relative proportions of the constituent first gas and the constituent second gas in the gas mixture to a desired value.