An ingredient delivery device, comprising: an ingredient-containing reservoir, wherein the reservoir is in liquid or gel matrix form, or is made of an absorbable material; and wherein the ingredient-containing reservoir defines a perimeter; a backing layer having a cavity overlying the ingredient-containing reservoir, wherein the backing layer is made of a polymer material which is substantially impermeable to ingredients contained in the reservoir; a cover for the reservoir, the cover being made of a material substantially impermeable to ingredients contained in the reservoir, but having at least one opening defining a perimeter, such that ingredients to be delivered from the reservoir will flow through the opening but will not readily flow through the material of which the cover is made; a first seal sealing the cover to the backing layer at the perimeter of the reservoir, wherein the first seal is not subject to permeation, disintegration or degradation by any ingredient contained in the reservoir; an adhesive layer adhered to the backing layer for adhering the device to a patient's skin or mucosa, the adhesive layer not extending to the perimeter of the opening in the cover, such that a portion of the cover surrounding the perimeter of the opening is exposed to thereby define a cover sealing surface; a microprotrusion array at least partially adhered to the adhesive layer having a plurality of microprotrusions, the microprotrusion array including at least one opening therethrough generally aligned with the opening in the cover, such that ingredients to be delivered from the reservoir, flow through the opening in the microprotrusion array, wherein the microprotrusion array pierces at least a portion of the skin or mucosa when the device is applied to a patient's skin or mucosa; a second seal; and a release liner covering the sealing surface of the cover and the opening of the cover, the liner being releasably sealed to the sealing surface of the cover by the second seal, wherein the second seal is not subject to permeation, disintegration or degradation by any ingredient in the reservoir; wherein the microprotrusions of the array comprise a biocompatible, biodegradable polymer; whereby ingredients contained in the reservoir are sealed therein during storage and non-use by the first and second seals, but are free to flow through the openings in the microprotrusion array and the cover and onto a patient's skin or mucosa when the liner is removed from the device and the device is applied to skin or mucosa. an ingredient-containing reservoir, wherein the reservoir is in liquid or gel matrix form, or is made of an absorbable material; and wherein the ingredient-containing reservoir defines a perimeter; a backing layer having a cavity overlying the ingredient-containing reservoir, wherein the backing layer is made of a polymer material which is substantially impermeable to ingredients contained in the reservoir; a cover for the reservoir, the cover being made of a material substantially impermeable to ingredients contained in the reservoir, but having at least one opening defining a perimeter, such that ingredients to be delivered from the reservoir will flow through the opening but will not readily flow through the material of which the cover is made; a first seal sealing the cover to the backing layer at the perimeter of the reservoir, wherein the first seal is not subject to permeation, disintegration or degradation by any ingredient contained in the reservoir; an adhesive layer adhered to the backing layer for adhering the device to a patient's skin or mucosa, the adhesive layer not extending to the perimeter of the opening in the cover, such that a portion of the cover surrounding the perimeter of the opening is exposed to thereby define a cover sealing surface; a microprotrusion array at least partially adhered to the adhesive layer having a plurality of microprotrusions, the microprotrusion array including at least one opening therethrough generally aligned with the opening in the cover, such that ingredients to be delivered from the reservoir, flow through the opening in the microprotrusion array, wherein the microprotrusion array pierces at least a portion of the skin or mucosa when the device is applied to a patient's skin or mucosa; a second seal; and a release liner covering the sealing surface of the cover and the opening of the cover, the liner being releasably sealed to the sealing surface of the cover by the second seal, wherein the second seal is not subject to permeation, disintegration or degradation by any ingredient in the reservoir; wherein the microprotrusions of the array comprise a biocompatible, biodegradable polymer; whereby ingredients contained in the reservoir are sealed therein during storage and non-use by the first and second seals, but are free to flow through the openings in the microprotrusion array and the cover and onto a patient's skin or mucosa when the liner is removed from the device and the device is applied to skin or mucosa.