A system for enhanced surgical navigation through one or more branched luminal networks comprising: a computing device comprising a display device, and the system comprising an imaging device; wherein the computing device is configured to import, or to execute instructions causing it to plan, a navigation path to a target through one or more branched luminal networks using a first data set of computed tomography images previously acquired, wherein the display is configured to display the navigation path on a graphical user interface for navigation to the target and placement of a plurality of markers in tissue proximate the target, and wherein the computing device is configured to receive a second data set of computed tomography images including the plurality of markers; and wherein the imaging device is configured to capture fluoroscopic data of tissue proximate the plurality of markers; the computing device being further configured to register the fluoroscopic data to the second data set of computed tomography images based on marker position and marker orientation within the fluoroscopic data and marker position and orientation within the second data set of computed tomography images, wherein the computing device is configured to combine at least a portion of the second data set of computed tomography images with the fluoroscopic data into a combined image, and display the combined image on the graphical user interface, wherein the combined image includes at least one of a fused, superimposed, or overlaid image of at least a portion of the second data set of computed tomography images with the fluoroscopic data, wherein the combined image includes the target, the navigation path, the plurality of markers and luminal pathways of the branched luminal networks. a computing device comprising a display device, and the system comprising an imaging device; wherein the computing device is configured to import, or to execute instructions causing it to plan, a navigation path to a target through one or more branched luminal networks using a first data set of computed tomography images previously acquired, wherein the display is configured to display the navigation path on a graphical user interface for navigation to the target and placement of a plurality of markers in tissue proximate the target, and wherein the computing device is configured to receive a second data set of computed tomography images including the plurality of markers; and wherein the imaging device is configured to capture fluoroscopic data of tissue proximate the plurality of markers; the computing device being further configured to register the fluoroscopic data to the second data set of computed tomography images based on marker position and marker orientation within the fluoroscopic data and marker position and orientation within the second data set of computed tomography images, wherein the computing device is configured to combine at least a portion of the second data set of computed tomography images with the fluoroscopic data into a combined image, and display the combined image on the graphical user interface, wherein the combined image includes at least one of a fused, superimposed, or overlaid image of at least a portion of the second data set of computed tomography images with the fluoroscopic data, wherein the combined image includes the target, the navigation path, the plurality of markers and luminal pathways of the branched luminal networks.