A method for preventing and handling in-car air pollution, applicable for dealing with air pollutant by air exchanging and filtering of a polluted air in an interior space of a car, the method comprises: providing an out-car pollution detector to detect the polluted air outside the car and transmit an out-car air detection data; providing an in-car pollution detector to detect the polluted air in the interior space of the car and transmit an in-car air detection data; providing an in-car air exchange system for controlling and determining if it is needed to introduce a air outside the car into the interior space of the car, wherein the in-car air exchange system comprises a cleaning unit and a control driving unit; the cleaning unit is provided for filtering the polluted air in the interior space of the car, and the control driving unit receives the out-car air detection data and the in-car air detection data and compares the out-car air detection data with the in-car air detection data; and providing an intelligent selection for introducing the air outside the car by the in-car air exchange system after the control driving unit compares the out-car air detection data with the in-car air detection data, so that the polluted air in the interior space of the car is filtered and exchanged out of the car, thereby allowing the polluted air in the interior space of the car to be exchanged and filtered to be a clean, safe, and breathable air, characterized in that: the in-car air exchange system has at least one air inlet and at least one air outlet; the air outside the car enters into the in-car air exchange system through the at least one air inlet and passes through the cleaning unit for filtering, and then the air is introduced into the interior space of the car through the at least one air outlet; the at least one air inlet is connected to an inlet channel and comprises an inlet valve for opening or closing the at least one air inlet; the air outlet is connected to a flow-guiding component; the in-car air exchange system further comprises an air-exchange inlet, an air-exchange channel, and an air-exchange outlet; the air-exchange inlet is connected to the air-exchange channel, the air-exchange channel is in communication with the air-exchange outlet and the inlet channel; the air-exchange outlet comprises an outlet valve for opening or closing the air-exchange outlet. providing an out-car pollution detector to detect the polluted air outside the car and transmit an out-car air detection data; providing an in-car pollution detector to detect the polluted air in the interior space of the car and transmit an in-car air detection data; providing an in-car air exchange system for controlling and determining if it is needed to introduce a air outside the car into the interior space of the car, wherein the in-car air exchange system comprises a cleaning unit and a control driving unit; the cleaning unit is provided for filtering the polluted air in the interior space of the car, and the control driving unit receives the out-car air detection data and the in-car air detection data and compares the out-car air detection data with the in-car air detection data; and providing an intelligent selection for introducing the air outside the car by the in-car air exchange system after the control driving unit compares the out-car air detection data with the in-car air detection data, so that the polluted air in the interior space of the car is filtered and exchanged out of the car, thereby allowing the polluted air in the interior space of the car to be exchanged and filtered to be a clean, safe, and breathable air, characterized in that: the in-car air exchange system has at least one air inlet and at least one air outlet; the air outside the car enters into the in-car air exchange system through the at least one air inlet and passes through the cleaning unit for filtering, and then the air is introduced into the interior space of the car through the at least one air outlet; the at least one air inlet is connected to an inlet channel and comprises an inlet valve for opening or closing the at least one air inlet; the air outlet is connected to a flow-guiding component; the in-car air exchange system further comprises an air-exchange inlet, an air-exchange channel, and an air-exchange outlet; the air-exchange inlet is connected to the air-exchange channel, the air-exchange channel is in communication with the air-exchange outlet and the inlet channel; the air-exchange outlet comprises an outlet valve for opening or closing the air-exchange outlet.