mhurhangee/ep-ind-claims huggingface dataset:
A method of evaluating genomic DNA, the method comprising: providing a plurality of DNA samples, wherein at least one sample of the plurality is a reference sample, with a known number of copies for each interrogated genomic locus, and at least one sample is a genomic DNA sample of unknown genomic content; providing a particle mixture comprising particles from different particle sets, wherein each particle set contains numerous encoded particles, wherein each particle within a set comprises i) the same code, and ii) a nucleic acid hybridization probe for a particular genomic locus, wherein the nucleic acid hybridization probe of each particle comprises cloned nucleic acid produced by sonicating a cloned nucleic acid comprising a sequence of the genomic locus or comprises a fragment from a mixture of fragments comprising randomly overlapping sequences and wherein each different particle set is specific for a different genomic locus, such that the mixture collectively includes probes for a plurality of different genomic loci; labelling the DNA samples with a single label or with an indirect label; contacting each of the samples to a portion of the particle mixture under hybridization conditions; and evaluating hybridization of each of the samples to particles in the respective portion of the mixture by monitoring the label, wherein signals from monitoring the reference sample are compared to signals from other samples to determine the number of copies of each interrogated genomic locus for the samples. providing a plurality of DNA samples, wherein at least one sample of the plurality is a reference sample, with a known number of copies for each interrogated genomic locus, and at least one sample is a genomic DNA sample of unknown genomic content; providing a particle mixture comprising particles from different particle sets, wherein each particle set contains numerous encoded particles, wherein each particle within a set comprises i) the same code, and ii) a nucleic acid hybridization probe for a particular genomic locus, wherein the nucleic acid hybridization probe of each particle comprises cloned nucleic acid produced by sonicating a cloned nucleic acid comprising a sequence of the genomic locus or comprises a fragment from a mixture of fragments comprising randomly overlapping sequences and wherein each different particle set is specific for a different genomic locus, such that the mixture collectively includes probes for a plurality of different genomic loci; labelling the DNA samples with a single label or with an indirect label; contacting each of the samples to a portion of the particle mixture under hybridization conditions; and evaluating hybridization of each of the samples to particles in the respective portion of the mixture by monitoring the label, wherein signals from monitoring the reference sample are compared to signals from other samples to determine the number of copies of each interrogated genomic locus for the samples.
Method for configuring a modular control device of an industrial automation system, in which - the control device comprises a central processing unit for processing control programs and at least one communication module which each comprise an integrated router and are connected to one another via a backplane bus system, - each integrated router is allocated either a role as a first router or a role as a second router, first routers, as uplink routers, having an extended router function for a connection to a superordinate communication network, and second routers, as downlink routers, having a restricted router function for a connection to a subordinate field level subnetwork, characterized in that - router configuration units of the first routers each use router configuration units of other routers to capture available router functions and assigned priority values of the respective routers, - the router configuration units of the first routers each use the captured router functions of other routers to check whether further first routers are available, - if further first routers are available, the router configuration units of the first routers each use the priority values to check which first router is assigned the highest priority value, - the first router with the highest priority value is configured as the superordinate router for a connection to a superordinate communication network, - all other routers are each configured as subordinate routers for a connection to a subordinate field level subnetwork and assume a name service and subnetwork address configuration predefined by the superordinate router. - the control device comprises a central processing unit for processing control programs and at least one communication module which each comprise an integrated router and are connected to one another via a backplane bus system, - each integrated router is allocated either a role as a first router or a role as a second router, first routers, as uplink routers, having an extended router function for a connection to a superordinate communication network, and second routers, as downlink routers, having a restricted router function for a connection to a subordinate field level subnetwork, characterized in that - router configuration units of the first routers each use router configuration units of other routers to capture available router functions and assigned priority values of the respective routers, - the router configuration units of the first routers each use the captured router functions of other routers to check whether further first routers are available, - if further first routers are available, the router configuration units of the first routers each use the priority values to check which first router is assigned the highest priority value, - the first router with the highest priority value is configured as the superordinate router for a connection to a superordinate communication network, - all other routers are each configured as subordinate routers for a connection to a subordinate field level subnetwork and assume a name service and subnetwork address configuration predefined by the superordinate router.
A system for transporting an Short Message Service,SMS, message from a sending Mobile Network Operator party, MNO A, to a receiving Mobile Network Operator party, MNO B, wherein the MNO B uses a sponsor Mobile Network Operator party, MNO S, within the context of SMS interworking services and wherein the system comprises a component, WB, in a routing path between MNO B and MNO A, the component, WB, being arranged for: - receiving a Request to send Routing Info for Short Message,SRI for SM response, sent by MNO B, the SRI for SM response comprising an International Mobile Subscriber Identity,IMSI; - reading a SMS, routing information in the SRI for SM response; - accessing data relating to an SMS interworking arrangement between the MNO A, and the MNO B, - establishing, dependent on the data relating to the SMS interworking arrangement between the MNO A, and the MNO B, whether use of the MNO S, is required or preferred and - if use of the MNO S, is required or preferred, amending the SMS routing information data in the SRI for SM response, wherein the component introduces itself as the receiving MNO to the sending MNO using a Global Title, GT, address from the MNO S and replaces the IMSI in the SRI for SM response with a Sponsored B-IMSI; - if the use of the MNO S is not required, passing on the SRI for SM response sent by the MNO B; - receiving a subsequent SMS Mobile Terminating,SMS MT, request by the component and a SMS MT response message, wherein the component maps in the SMS MT request and SMS MT response the sponsored GT addresses to/from the corresponding sending MNO or receiving MNO GT addresses, and replaces in the SMS MT request the Sponsored B-IMSI with the IMSI comprised in the SRI for SM response. - receiving a Request to send Routing Info for Short Message,SRI for SM response, sent by MNO B, the SRI for SM response comprising an International Mobile Subscriber Identity,IMSI; - reading a SMS, routing information in the SRI for SM response; - accessing data relating to an SMS interworking arrangement between the MNO A, and the MNO B, - establishing, dependent on the data relating to the SMS interworking arrangement between the MNO A, and the MNO B, whether use of the MNO S, is required or preferred and - if use of the MNO S, is required or preferred, amending the SMS routing information data in the SRI for SM response, wherein the component introduces itself as the receiving MNO to the sending MNO using a Global Title, GT, address from the MNO S and replaces the IMSI in the SRI for SM response with a Sponsored B-IMSI; - if the use of the MNO S is not required, passing on the SRI for SM response sent by the MNO B; - receiving a subsequent SMS Mobile Terminating,SMS MT, request by the component and a SMS MT response message, wherein the component maps in the SMS MT request and SMS MT response the sponsored GT addresses to/from the corresponding sending MNO or receiving MNO GT addresses, and replaces in the SMS MT request the Sponsored B-IMSI with the IMSI comprised in the SRI for SM response.
A dual-chambered medical barrel comprising an inner wall and an outer wall, the inner wall comprising at least one bypass groove having a substantially constant cross section, wherein the outer wall adjacent to the bypass groove has a surface geometry that is unaltered by the bypass groove, the medical barrel being made from an injection moldable thermoplastic material, characterised in that the dual-chambered medical barrel comprises a pH protective organo-siloxane coating or layer applied by plasma enhanced chemical vapor deposition (PECVD) to the inner wall.
A tire comprising a buttress surface extending inward in a tire radial direction from a tread ground-contact end (Te), wherein the tire has a plurality of line grooves recessed inward from the buttress surface and extending on the buttress surface and a plurality of ridges protruding outward from the buttress surface and extending on the buttress surface, and the line grooves and the ridges are alternately arranged, wherein the tread ground-contact ends (Te) are defined as ground contact positions at the outermost sides in the tire axial direction, when a normal load is applied to the tire in the normal state and the tire is brought into contact with a flat surface at a camber angle of 0°. a buttress surface extending inward in a tire radial direction from a tread ground-contact end (Te), wherein the tire has a plurality of line grooves recessed inward from the buttress surface and extending on the buttress surface and a plurality of ridges protruding outward from the buttress surface and extending on the buttress surface, and the line grooves and the ridges are alternately arranged, wherein the tread ground-contact ends (Te) are defined as ground contact positions at the outermost sides in the tire axial direction, when a normal load is applied to the tire in the normal state and the tire is brought into contact with a flat surface at a camber angle of 0°.
Home automation system comprising, - at least one evaluation device, - display means arranged to display a view of at least a part of a floor plan of a spatial environment of the home automation system, and, - programming means arranged for programming at least one action of an actuator of the home automation system based on the currently displayed view of the floor plan and on a function of the actuator and/or a sensor of the home automation system, characterized in that - the evaluation device obtains, from the reception signals of a transmitter received by at least two sensors, a respective reception field strength together with a transmitter identification and a sensor identification as reception information, and detects a position from the reception information, - such that a mobile display device of the display means displays a part of the floor plan depending on the detected position within the floor plan. - at least one evaluation device, - display means arranged to display a view of at least a part of a floor plan of a spatial environment of the home automation system, and, - programming means arranged for programming at least one action of an actuator of the home automation system based on the currently displayed view of the floor plan and on a function of the actuator and/or a sensor of the home automation system, characterized in that - the evaluation device obtains, from the reception signals of a transmitter received by at least two sensors, a respective reception field strength together with a transmitter identification and a sensor identification as reception information, and detects a position from the reception information, - such that a mobile display device of the display means displays a part of the floor plan depending on the detected position within the floor plan.
A process for preparing a glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain thereof, the process comprising: esterifying a hydroxyl group of a resin having the hydroxyl group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, removing the fat-soluble protective group to form a free amino group, amidating the free amino group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, removing the fat-soluble protective group to form a free amino group, repeating the steps and at least once, amidating the free amino group and a carboxyl group of the asparagine portion of an asparagine-linked disialooligosaccharide or asparagine-linked monosialooligosaccharide having the hydroxy groups unprotected and having amino group nitrogen protected with a fat-soluble protective group and the carboxyl group of the sialic acid protected with a benzyl, allyl, or diphenylmethyl group, removing the fat-soluble protective group to form a free amino group, amidating the free amino group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, repeating the steps and at least once, removing the fat-soluble protective group to form a free amino group, cutting off the resin with an acid, and transferring fluoro-sialic acid to the resulting glycopeptide using a sialic acid transferase and CMP-7-fluoro-sialic acid, CMP-8-fluoro-sialic acid, or CMP-9-fluoro-sialic acid. esterifying a hydroxyl group of a resin having the hydroxyl group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, removing the fat-soluble protective group to form a free amino group, amidating the free amino group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, removing the fat-soluble protective group to form a free amino group, repeating the steps and at least once, amidating the free amino group and a carboxyl group of the asparagine portion of an asparagine-linked disialooligosaccharide or asparagine-linked monosialooligosaccharide having the hydroxy groups unprotected and having amino group nitrogen protected with a fat-soluble protective group and the carboxyl group of the sialic acid protected with a benzyl, allyl, or diphenylmethyl group, removing the fat-soluble protective group to form a free amino group, amidating the free amino group and a carboxyl group of an amino acid having amino group nitrogen protected with a fat-soluble protective group, repeating the steps and at least once, removing the fat-soluble protective group to form a free amino group, cutting off the resin with an acid, and transferring fluoro-sialic acid to the resulting glycopeptide using a sialic acid transferase and CMP-7-fluoro-sialic acid, CMP-8-fluoro-sialic acid, or CMP-9-fluoro-sialic acid.
An mRNA-mannose conjugate, comprising an mRNA encoding a polypeptide with at least one 5' cap structure, a 5' UTR with at least one Kozak sequence, a 3' UTR, and a polyA tail, and at least one mannose attached to the mRNA via an amine at a 3' terminus of the mRNA, and wherein the mRNA comprises uridine, cytidine, adenosine, guanosine and/or chemically modified nucleosides thereof, wherein the amine is a secondary amine, and wherein the amine is formed on a last adenine of the polyA tail of the mRNA.
An antibody or antigen-binding fragment thereof that binds a Factor IX Padua comprising the amino acid sequence of SEQ ID NO: 1 and does not bind to a wild-type Factor IX comprising the amino acid sequence of SEQ ID NO: 2, wherein the antibody or antigen-binding fragment thereof comprises the amino acid sequences of: SSYAIS (SEQ ID NO: 6); GIVPAFGTANYAQKFQG (SEQ ID NO: 7); SWGVISFAY (SEQ ID NO: 8); RASQDISSYLN (SEQ ID NO: 9); AASNLQS (SEQ ID NO: 10); and MQYDSLPFTF (SEQ ID NO: 11).
An in vitro or ex vivo method of producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the steps of: (a) providing a population of cells comprising neutrophil progenitor cells in an animal cell culture medium and at an initial cell density of less than 20,000 neutrophil progenitor cells per ml; (b) culturing the population of cells under conditions of low oxidative stress, which comprise a dissolved oxygen content of the culture less than 10% and wherein the animal cell culture medium comprises (i) one or more early acting cytokines which are not neutrophil pathway specific but act on stem cells and progenitor cells to promote growth and expansion and (ii) one or more cytokines that differentiate said progenitor cells into a neutrophil specific lineage to produce a population of progeny cells at a density of at least 100,000 cells per ml of medium; (c) determining a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and the progeny thereof under static conditions; and (d) agitating the culture medium during continued culture of the cells once the cells reach the cell density determined in (c) to produce a population of post-mitotic cells of the neutrophil lineage. (a) providing a population of cells comprising neutrophil progenitor cells in an animal cell culture medium and at an initial cell density of less than 20,000 neutrophil progenitor cells per ml; (b) culturing the population of cells under conditions of low oxidative stress, which comprise a dissolved oxygen content of the culture less than 10% and wherein the animal cell culture medium comprises (i) one or more early acting cytokines which are not neutrophil pathway specific but act on stem cells and progenitor cells to promote growth and expansion and (ii) one or more cytokines that differentiate said progenitor cells into a neutrophil specific lineage to produce a population of progeny cells at a density of at least 100,000 cells per ml of medium; (c) determining a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and the progeny thereof under static conditions; and (d) agitating the culture medium during continued culture of the cells once the cells reach the cell density determined in (c) to produce a population of post-mitotic cells of the neutrophil lineage.
Triggering unit for a fire extinguishing system with at least one extinguishing agent container, to which at least one extinguishing agent pipe is connected, and wherein at least one extinguishing agent nozzle is provided, which is connected to the extinguishing agent pipe, wherein, if the extinguishing agent container is activated, an extinguishing agent is releasable and can be guided through the extinguishing agent pipe to the extinguishing agent nozzle, wherein the activation of the extinguishing agent container can be triggered by a pressure increase in the extinguishing agent pipe, wherein the triggering unit comprises an opening element which triggers the pressure increase in the extinguishing agent pipe, characterized in that a temperature-dependent activating element is integrated in the extinguishing agent pipe together with a pressure accumulator, wherein the activating element is configured for activating the pressure accumulator.
An incubation system (50, 150) for automated cell culture and/or testing, the system comprising: a housing forming a chamber; a rack defining storage positions to support an array of sample holders inside the chamber; a detection robot to capture one or more images of cells contained by one or more wells of each sample holder while the sample holder remains at one of the storage positions of the rack, wherein the detection robot is movable along three orthogonal axes, to reach every well of each sample holder supported by the rack; a fluid handling station configured to add fluid to, and/or remove fluid from, the one or more wells of each of the sample holders inside the housing; at least one plate robot to move sample holders between the rack and the fluid handling station; and a computer to control operation of the detection robot, the fluid handling station, and the at least one plate robot. a housing forming a chamber; a rack defining storage positions to support an array of sample holders inside the chamber; a detection robot to capture one or more images of cells contained by one or more wells of each sample holder while the sample holder remains at one of the storage positions of the rack, wherein the detection robot is movable along three orthogonal axes, to reach every well of each sample holder supported by the rack; a fluid handling station configured to add fluid to, and/or remove fluid from, the one or more wells of each of the sample holders inside the housing; at least one plate robot to move sample holders between the rack and the fluid handling station; and a computer to control operation of the detection robot, the fluid handling station, and the at least one plate robot.
A surface treating composition for copper or a copper alloy, comprising an imidazole compound represented by the chemical formula: wherein R represents a hydrogen atom or a methyl group, and Y represents a phenyl group, a group represented by formula or a group represented by formula, wherein n is 0, 1 or 2, and wherein the imidazole compound is present in the composition in an amount of from 0.01 wt% to 10 wt%.
A method for controlling an exhaust gas purification system, comprising: an exhaust gas purification device including an oxidation catalyst device for carrying an oxidation catalyst and a diesel particulate filter device in order from an upstream side in an exhaust passage of an internal combustion engine, or an exhaust gas purification device including a diesel particulate filter device for carrying an oxidation catalyst; index temperature detection means for detecting a catalyst temperature index temperature that indexes the temperature of the oxidation catalyst; a control device for performing regeneration control based on a detection result of the index temperature detection means in order to recover a purification capacity of the diesel particulate filter device, characterized in that during regeneration control when a vehicle mounted with the internal combustion engine is stopped, a first exhaust gas temperature rise control is performed to make an engine speed of idling to a predetermined first objective engine speed that is higher than the engine speed of idling in a normal operation when a catalyst temperature index temperature is lower than a first determination temperature, and a second exhaust gas temperature rise control is performed to make the engine speed of idling lower than the predetermined first objective engine speed and a predetermined second objective engine speed that is higher than the engine speed of idling in the normal operation when the catalyst temperature index temperature is not less than the predetermined first determination temperature, wherein the predetermined first determination temperature is a temperature at which unburned fuel is oxidized in the oxidation catalyst.