A device for needle biopsy comprising: an adjustable delivery handle system comprising: a delivery handle, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable needle subassemblies; and a sheath coupled to a distal end of the delivery handle and having a lumen in fluid communication with the inner lumen of the delivery handle; and a needle subassembly removably disposed within the inner lumen of the delivery handle and the lumen of the sheath, the needle subassembly comprising an exchangeable biopsy needle comprising: an elongate tubular body comprising a lumen extending therethrough from a proximal open end to a distal open end of the body, the distal end comprising a first tip portion extending from the distal end and having a first length and a second tip portion extending from the distal end and having a second length that is less than the first length of the first tip portion, such that the first tip portion is configured to contact and engage tissue to be sampled prior to the second tip portion, wherein the first tip portion of the needle is formed from first and second angular bevel grinds oblique to the longitudinal axis of the body, wherein the second tip portion of the needle is formed from third and fourth angular bevel grinds oblique to the longitudinal axis of the body, wherein the first and third angular bevel grinds form first and second distinct curved cutting edges (320, 324) on a first side of the body, and wherein the second and fourth angular bevel grinds form third and fourth distinct curved cutting edges on a second side of the body opposite the first side wherein the distal end of the body of the needle comprises additional third and fourth tip portions formed between the first and second tip portions (306, 314), wherein the first and second tip portions (306, 314) radially oppose one another on either side of the needle body and the third and fourth tip portions radially oppose one another on either side of the needle body, wherein the first, second, third and fourth curved cutting edges (320, 324) are formed between the tip portions, and wherein the first tip portion is longer than the third tip portion and the third tip portion is longer than the second tip portion. a delivery handle, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable needle subassemblies; and a sheath coupled to a distal end of the delivery handle and having a lumen in fluid communication with the inner lumen of the delivery handle; and a needle subassembly removably disposed within the inner lumen of the delivery handle and the lumen of the sheath, the needle subassembly comprising an exchangeable biopsy needle comprising: an elongate tubular body comprising a lumen extending therethrough from a proximal open end to a distal open end of the body, the distal end comprising a first tip portion extending from the distal end and having a first length and a second tip portion extending from the distal end and having a second length that is less than the first length of the first tip portion, such that the first tip portion is configured to contact and engage tissue to be sampled prior to the second tip portion, wherein the first tip portion of the needle is formed from first and second angular bevel grinds oblique to the longitudinal axis of the body, wherein the second tip portion of the needle is formed from third and fourth angular bevel grinds oblique to the longitudinal axis of the body, wherein the first and third angular bevel grinds form first and second distinct curved cutting edges (320, 324) on a first side of the body, and wherein the second and fourth angular bevel grinds form third and fourth distinct curved cutting edges on a second side of the body opposite the first side an elongate tubular body comprising a lumen extending therethrough from a proximal open end to a distal open end of the body, the distal end comprising a first tip portion extending from the distal end and having a first length and a second tip portion extending from the distal end and having a second length that is less than the first length of the first tip portion, such that the first tip portion is configured to contact and engage tissue to be sampled prior to the second tip portion, wherein the first tip portion of the needle is formed from first and second angular bevel grinds oblique to the longitudinal axis of the body, wherein the second tip portion of the needle is formed from third and fourth angular bevel grinds oblique to the longitudinal axis of the body, wherein the first and third angular bevel grinds form first and second distinct curved cutting edges (320, 324) on a first side of the body, and wherein the second and fourth angular bevel grinds form third and fourth distinct curved cutting edges on a second side of the body opposite the first side wherein the distal end of the body of the needle comprises additional third and fourth tip portions formed between the first and second tip portions (306, 314), wherein the first and second tip portions (306, 314) radially oppose one another on either side of the needle body and the third and fourth tip portions radially oppose one another on either side of the needle body, wherein the first, second, third and fourth curved cutting edges (320, 324) are formed between the tip portions, and wherein the first tip portion is longer than the third tip portion and the third tip portion is longer than the second tip portion.