Granulation method consisting of the following steps: a -incorporating, into a nutritional mixture adapted to the target application, a probiotic composition consisting of: - 2 to 30% by weight of the total weight of the composition, of probiotic yeast in a dry form agglomerated into spherules having content of dry matter equal to between 93 and 98% and a median spherule diameter (d) equal to between 800 and 1200μm, and - from 70 to 98% by weight of the total weight of the composition, of a nutritional complement comprising at least one constituent chosen from vitamins, trace elements, amino acids and other additives intended for animal or human food and/or health. b -injecting steam at a temperature of between 60°C and 85°C at pressures varying from 0.5 to 4 bars in the mixture obtained in the previous step, c -granulating by pressing at a temperature of between 70°C and 92°C to obtain granules of large diameter granules of between 2 and 6 mm, and d -cooling, characterised in that the temperature of the granulation press, the diameter of the granules, the content of dry matter and the median diameter (d) of the spherules are defined to satisfy the following equation: X = - 196.482 - 0.023 d + 2.256 MS - 14.793 T + 3.046 D + 6.25 ⁢ x ⁢ 10 - 5 ⁢ d MS + 0.001 d. T + 5.63 x ⁢ 10 - 5 ⁢ d. T + 0.167 MS. T - 0.036 MS. T - 0.023 ⁢ D. T + 4.06 ⁢ x ⁢ 10 - 6 ⁢ d 2 + 0.003 ⁢ T 2 in which yeast losses after granulation X (logCFU/g initial - logCFU/g after granulation) are less than 1 log CFU/g of granulated food, and in which the probiotic yeast is chosen from yeasts corresponding to those chosen from the group comprising the Saccharomyces cerevisiae strain Sc47 deposited at the NCYC under number 47, the Saccharomyces cerevisiae strain deposited at the Pasteur collection (CNCM) under number 1-1077, the Saccharomyces cerevisiae strain deposited at the Pasteur collection (CNCM) under number 1-1079, the Saccharomyces cerevisiae strain deposited at the MUCL collection under number 39 885, the Saccharomyces cerevisiae strain deposited at the CBS collection under number 39 493.94, the Kluyveromyces marxianus strain deposited at the MUCL collection under number 39434 and mixtures thereof. a -incorporating, into a nutritional mixture adapted to the target application, a probiotic composition consisting of: - 2 to 30% by weight of the total weight of the composition, of probiotic yeast in a dry form agglomerated into spherules having content of dry matter equal to between 93 and 98% and a median spherule diameter (d) equal to between 800 and 1200μm, and - from 70 to 98% by weight of the total weight of the composition, of a nutritional complement comprising at least one constituent chosen from vitamins, trace elements, amino acids and other additives intended for animal or human food and/or health. - 2 to 30% by weight of the total weight of the composition, of probiotic yeast in a dry form agglomerated into spherules having content of dry matter equal to between 93 and 98% and a median spherule diameter (d) equal to between 800 and 1200μm, and - from 70 to 98% by weight of the total weight of the composition, of a nutritional complement comprising at least one constituent chosen from vitamins, trace elements, amino acids and other additives intended for animal or human food and/or health. b -injecting steam at a temperature of between 60°C and 85°C at pressures varying from 0.5 to 4 bars in the mixture obtained in the previous step, c -granulating by pressing at a temperature of between 70°C and 92°C to obtain granules of large diameter granules of between 2 and 6 mm, and d -cooling,