A compound according to Formula I: or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein: W 1 is selected from N and CR 1; W 2 is selected from N and CR 2; W 3 is selected from N and CR 3; W 4 is selected from N and CR 4; X is selected from N and CH; Y is selected from -S -,-NH-, -NHCH 2 -, -NHCH 2 CH 2 -, and -NHCH 2 CH 2 CH 2 -, wherein if Y is -NH-, -NHCH 2 -, -NHCH 2 CH 2 -, or -NHCH 2 CH 2 CH 2 -, then the nitrogen is attached to the B ring, and one or more hydrogens may be optionally substituted with alkyl(C 1 -C 3), halogen, hydroxyl, or amino; R 1, R 2, R 3, and R 4 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amino, aryloxy, aryl, hydroxyl, and halogen; wherein each alkyl and alkoxy may be optionally substituted with hydroxyl, amino, or halogen, and wherein each aryl and aryloxy may be optionally substituted with halogen, alkoxy, or amino, and wherein two adjacent substituents selected from R 1, R 2, R 3, and R 4 may be connected in a 5- or 6-membered ring to form a bicyclic carbocycle or bicyclic heterocycle; R 5 is selected from amino and 5- and 6- membered carbocycles and heterocycles, which may optionally be substituted with halogen, amino, urea, ester, carbamate, amide, alkyl(C 1 -C 6), alkoxy(C 1 -C 6), or aryl; R 6 is selected from hydrogen, alkoxy, alkyl, halogen, aminoalkyl, and thioalkyl, wherein said alkyl, alkoxy, aminoalkyl or thioalkyl is optionally substituted with halogen, amino, hydroxyl or alkoxy; and R 7 is selected from hydrogen, alkyl, alkoxy, thioalkyl, aminoalkyl, and halogen; and wherein amino refers to -NR d R e or -N(R d)R e -, where R d and R e are independently selected from alkyl, alkenyl, alkynyl, aryl, arylalkyl, carbamate, cycloalkyl, haloalkyl, heteroaryl, heterocycle, and hydrogen, wherein R d and R e each may be optionally substituted with hydroxyl, halogen, alkoxy, ester, or amino. W 1 is selected from N and CR 1; W 2 is selected from N and CR 2; W 3 is selected from N and CR 3; W 4 is selected from N and CR 4; X is selected from N and CH; Y is selected from -S -,-NH-, -NHCH 2 -, -NHCH 2 CH 2 -, and -NHCH 2 CH 2 CH 2 -, wherein if Y is -NH-, -NHCH 2 -, -NHCH 2 CH 2 -, or -NHCH 2 CH 2 CH 2 -, then the nitrogen is attached to the B ring, and one or more hydrogens may be optionally substituted with alkyl(C 1 -C 3), halogen, hydroxyl, or amino; R 1, R 2, R 3, and R 4 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amino, aryloxy, aryl, hydroxyl, and halogen; wherein each alkyl and alkoxy may be optionally substituted with hydroxyl, amino, or halogen, and wherein each aryl and aryloxy may be optionally substituted with halogen, alkoxy, or amino, and wherein two adjacent substituents selected from R 1, R 2, R 3, and R 4 may be connected in a 5- or 6-membered ring to form a bicyclic carbocycle or bicyclic heterocycle; R 5 is selected from amino and 5- and 6- membered carbocycles and heterocycles, which may optionally be substituted with halogen, amino, urea, ester, carbamate, amide, alkyl(C 1 -C 6), alkoxy(C 1 -C 6), or aryl; R 6 is selected from hydrogen, alkoxy, alkyl, halogen, aminoalkyl, and thioalkyl, wherein said alkyl, alkoxy, aminoalkyl or thioalkyl is optionally substituted with halogen, amino, hydroxyl or alkoxy; and R 7 is selected from hydrogen, alkyl, alkoxy, thioalkyl, aminoalkyl, and halogen; and wherein amino refers to -NR d R e or -N(R d)R e -, where R d and R e are independently selected from alkyl, alkenyl, alkynyl, aryl, arylalkyl, carbamate, cycloalkyl, haloalkyl, heteroaryl, heterocycle, and hydrogen, wherein R d and R e each may be optionally substituted with hydroxyl, halogen, alkoxy, ester, or amino.