A neurostimulation system (10, 50), comprising: a neural stimulation lead comprising a plurality of electrodes (30a-30d) configured to be positioned proximate to an autonomic neural target; a neural stimulation circuit (76, 110), coupled to the plurality of electrodes (30a-30d), to deliver neural stimulation pulses to a plurality of electrode configurations, wherein each of the plurality of electrode configurations include at least one of the plurality of electrodes (30a-30d); at least one sensor (12, 54, 90) to sense motor fiber capture and sense at least one other physiological response; and a processor (86, 106) and controller (78, 112) configured to: test for a motor fiber capture threshold to prioritize further testing, including control the neural stimulation circuit (76, 110) to deliver first neural stimulation pulses to each of the plurality of electrode configurations and use the at least one sensor (12, 54, 90) to sense motor fiber capture, identify a subset of the plurality of electrode configurations that have a lowest motor fiber capture threshold for the further testing; and perform the further testing on the subset of the plurality of electrode configurations, including control the neural stimulation circuit (76, 110) to deliver second neural stimulation pulses to each electrode configuration in the subset and use the at least one sensor (12, 54, 90) to sense the at least one other physiological response, the second neural stimulation pulses having a different stimulation parameter value than the first neural stimulation pulses to induce the at least one other physiological response. a neural stimulation lead comprising a plurality of electrodes (30a-30d) configured to be positioned proximate to an autonomic neural target; a neural stimulation circuit (76, 110), coupled to the plurality of electrodes (30a-30d), to deliver neural stimulation pulses to a plurality of electrode configurations, wherein each of the plurality of electrode configurations include at least one of the plurality of electrodes (30a-30d); at least one sensor (12, 54, 90) to sense motor fiber capture and sense at least one other physiological response; and a processor (86, 106) and controller (78, 112) configured to: test for a motor fiber capture threshold to prioritize further testing, including control the neural stimulation circuit (76, 110) to deliver first neural stimulation pulses to each of the plurality of electrode configurations and use the at least one sensor (12, 54, 90) to sense motor fiber capture, identify a subset of the plurality of electrode configurations that have a lowest motor fiber capture threshold for the further testing; and perform the further testing on the subset of the plurality of electrode configurations, including control the neural stimulation circuit (76, 110) to deliver second neural stimulation pulses to each electrode configuration in the subset and use the at least one sensor (12, 54, 90) to sense the at least one other physiological response, the second neural stimulation pulses having a different stimulation parameter value than the first neural stimulation pulses to induce the at least one other physiological response.