An endoscope, comprising: an insertion portion which has a distal end hard portion at a distal end side and a treatment instrument insertion channel inside, and is inserted into a body cavity; an operation portion which is connected to a proximal end side of the insertion portion; and a treatment instrument raiser which is arranged near a distal end side opening of the treatment instrument insertion channel in the insertion portion, has a treatment instrument guiding surface for guiding a treatment instrument, and able to rise according to an operation from the operation portion, wherein the treatment instrument raiser includes a slit which is formed on a distal end side of the treatment instrument guiding surface and with which a guide wire guided toward the distal end side opening of the treatment instrument insertion channel can be engaged, and a guide wire guiding unit which is formed on an outer periphery of the treatment instrument guiding surface and serves to guide the guide wire into the slit, wherein the guide wire is configured to be guided into the slit by the guide wire guiding unit, when the treatment instrument raiser is raised by the operation from the operation portion, characterized in that the distal end hard portion has a retraction portion to avoid an interference of the guide wire guiding unit at a time the treatment instrument raiser is raised by the operation from the operation portion, and the treatment instrument guiding surface is a groove with a substantially V-shaped section. an insertion portion which has a distal end hard portion at a distal end side and a treatment instrument insertion channel inside, and is inserted into a body cavity; an operation portion which is connected to a proximal end side of the insertion portion; and a treatment instrument raiser which is arranged near a distal end side opening of the treatment instrument insertion channel in the insertion portion, has a treatment instrument guiding surface for guiding a treatment instrument, and able to rise according to an operation from the operation portion, wherein the treatment instrument raiser includes a slit which is formed on a distal end side of the treatment instrument guiding surface and with which a guide wire guided toward the distal end side opening of the treatment instrument insertion channel can be engaged, and a guide wire guiding unit which is formed on an outer periphery of the treatment instrument guiding surface and serves to guide the guide wire into the slit, wherein a slit which is formed on a distal end side of the treatment instrument guiding surface and with which a guide wire guided toward the distal end side opening of the treatment instrument insertion channel can be engaged, and a guide wire guiding unit which is formed on an outer periphery of the treatment instrument guiding surface and serves to guide the guide wire into the slit, wherein the guide wire is configured to be guided into the slit by the guide wire guiding unit, when the treatment instrument raiser is raised by the operation from the operation portion, characterized in that the distal end hard portion has a retraction portion to avoid an interference of the guide wire guiding unit at a time the treatment instrument raiser is raised by the operation from the operation portion, and the treatment instrument guiding surface is a groove with a substantially V-shaped section.