Compound of formula wherein: W 1, W 2, W 3, W 4 denotes independently from each other N or CR 3, W 5 denotes N or C, preferably denotes N or CR 3, more preferably denotes N, Z denotes C=C, N(R 4)CO, NR 4, O, CON(R 4), S, CH or N=N, R 1 denotes a monocyclic aryl having 5, 6, 7, 8, 9 or 10 C atoms or a monocyclic heteroaryl having 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, each of which can be independently substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3 or OY, R 2 denotes H, Hal, A, - n -OY, - n -NYY, - n -Het, SY, NO 2, CN, COOY, -CO-NYY, -NY-COA, -NY-SO 2 A,-SO2-NYY, S m A, -CO-Het, -O k -OY, -O n -NYY, -O n -Het, -NH-COOA, -NH-CO-NYY, -NH-COO- n -NYY, -NH-COO- n -Het, -NH-CO-NH- n -NYY, -NH-CO-NH n -Het, -OCO-NH- n -NYY,-OCO-NH- n -Het, CHO, COA or a monocyclic aryl having 5, 6, 7, 8, 9 or 10 C atoms or a monocyclic heteroaryl having 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, each of monocyclic aryl and monocyclic heteroaryl can be independently substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3 or OY, R 3 denotes H, OY, NYY, NY-COY, NY-CO- n -OY, NY-COY-NYY, NY- n -NYY, O- n -NYY or O- n -Het, R 4 denotes H, A, - o -Het, - o -NYY or - o -OY, R 5 denotes H, A, OY, NYY or Het, Y denotes H or A, in case of - n/o - Y denotes H, A or OH, A denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 H atoms can be replaced independently from one another by Hal; alternatively, A denotes cycloalkyl with 3, 4, 5, 6, 7 or 8 C-atoms, Het denotes a saturated or unsaturated, mono, bi- or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, which can be substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3, OY, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, o denotes 0, 1, 2, 3 or 4, preferably if Z is NR 4, o additionally denotes 2, 3 or 4, p denotes 0, 1, 2 or 3, q denotes 0, 1, 2 or 3, and the physiologically acceptable salts, solvates, stereoisomers and tautomers thereof, including mixtures thereof in all ratios. W 5 denotes N or C, preferably denotes N or CR 3, more preferably denotes N, Z denotes C=C, N(R 4)CO, NR 4, O, CON(R 4), S, CH or N=N, R 1 denotes a monocyclic aryl having 5, 6, 7, 8, 9 or 10 C atoms or a monocyclic heteroaryl having 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, each of which can be independently substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3 or OY, R 2 denotes H, Hal, A, - n -OY, - n -NYY, - n -Het, SY, NO 2, CN, COOY, -CO-NYY, -NY-COA, -NY-SO 2 A,-SO2-NYY, S m A, -CO-Het, -O k -OY, -O n -NYY, -O n -Het, -NH-COOA, -NH-CO-NYY, -NH-COO- n -NYY, -NH-COO- n -Het, -NH-CO-NH- n -NYY, -NH-CO-NH n -Het, -OCO-NH- n -NYY,-OCO-NH- n -Het, CHO, COA or a monocyclic aryl having 5, 6, 7, 8, 9 or 10 C atoms or a monocyclic heteroaryl having 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, each of monocyclic aryl and monocyclic heteroaryl can be independently substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3 or OY, R 3 denotes H, OY, NYY, NY-COY, NY-CO- n -OY, NY-COY-NYY, NY- n -NYY, O- n -NYY or O- n -Het, R 4 denotes H, A, - o -Het, - o -NYY or - o -OY, R 5 denotes H, A, OY, NYY or Het, Y denotes H or A, in case of - n/o - Y denotes H, A or OH, A denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 H atoms can be replaced independently from one another by Hal; alternatively, A denotes cycloalkyl with 3, 4, 5, 6, 7 or 8 C-atoms, Het denotes a saturated or unsaturated, mono, bi- or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 C atoms and 1, 2, 3, 4 or 5 N, O and/or S atoms, which can be substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF 3, OY, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, o denotes 0, 1, 2, 3 or 4, preferably if Z is NR 4, o additionally denotes 2, 3 or 4, p denotes 0, 1, 2 or 3, q denotes 0, 1, 2 or 3,