A high-strength steel sheet having excellent brittle crack arrestability, consisting of: 0.065 wt% to 0.1 wt% of carbon, 0.9 wt% to 1.5 wt% of manganese (Mn), 0.8 wt% to 1.5 wt% of nickel (Ni), 0.005 wt% to 0.1 wt% of niobium (Nb), 0.005 wt% to 0.1 wt% of titanium (Ti), 0.1 wt% to 0.6 wt% of copper (Cu), 0.1 wt% to 0.4 wt% of silicon (Si), 100 ppm or less of phosphorus, 40 ppm or less of sulfur, and the remainder being iron (Fe) and other inevitably contained impurities, the high-strength steel having a microstructure being one structure selected from the group consisting of a single-phase structure of ferrite, a single-phase structure of bainite, a complex structure of ferrite and bainite, a complex structure of ferrite and pearlite, and a complex structure of ferrite, bainite and pearlite, and having a thickness of 50 mm or more, wherein the contents of Cu and Ni are set such that a weight ratio of Cu/Ni is 0.6 or less, wherein the ferrite is acicular ferrite or polygonal ferrite, and the bainite is granular bainite, wherein when the microstructure of the high-strength steel sheet is a complex structure including pearlite, a fraction of pearlite is 20 volume% or less, wherein the steel sheet has a grain size of a crystal grain having a high angle boundary, in which a difference in crystal orientations measured in a region from a surface layer portion to a 1/4 thickness point thereof in a thickness direction using an EBSD method is 15 degrees or more, of 15 μm or less, wherein the steel sheet has a yield strength of 390 MPa or more, and wherein the steel sheet has an area ratio of a plane forming an angle of less than 15 degrees with respect to a plane thereof parallel to a rolling direction in a region from a surface layer portion to a 1/4 thickness point of the high-strength steel in a thickness direction of 30% or more. 0.065 wt% to 0.1 wt% of carbon, 0.9 wt% to 1.5 wt% of manganese (Mn), 0.8 wt% to 1.5 wt% of nickel (Ni), 0.005 wt% to 0.1 wt% of niobium (Nb), 0.005 wt% to 0.1 wt% of titanium (Ti), 0.1 wt% to 0.6 wt% of copper (Cu), 0.1 wt% to 0.4 wt% of silicon (Si), 100 ppm or less of phosphorus, 40 ppm or less of sulfur, and the remainder being iron (Fe) and other inevitably contained impurities, the high-strength steel having a microstructure being one structure selected from the group consisting of a single-phase structure of ferrite, a single-phase structure of bainite, a complex structure of ferrite and bainite, a complex structure of ferrite and pearlite, and a complex structure of ferrite, bainite and pearlite, and having a thickness of 50 mm or more, wherein the contents of Cu and Ni are set such that a weight ratio of Cu/Ni is 0.6 or less, wherein the ferrite is acicular ferrite or polygonal ferrite, and the bainite is granular bainite, wherein when the microstructure of the high-strength steel sheet is a complex structure including pearlite, a fraction of pearlite is 20 volume% or less, wherein the steel sheet has a grain size of a crystal grain having a high angle boundary, in which a difference in crystal orientations measured in a region from a surface layer portion to a 1/4 thickness point thereof in a thickness direction using an EBSD method is 15 degrees or more, of 15 μm or less, wherein the steel sheet has a yield strength of 390 MPa or more, and wherein the steel sheet has an area ratio of a plane forming an angle of less than 15 degrees with respect to a plane thereof parallel to a rolling direction in a region from a surface layer portion to a 1/4 thickness point of the high-strength steel in a thickness direction of 30% or more.