An automated endovascular perfusion augmentation system, the system comprising: a catheter having a proximal end portion and a distal end portion, the distal end portion configured for placement within an aorta of a patient; an expandable aortic blood flow regulation device disposed on the distal end portion of the catheter for placement within the aorta, the expandable aortic blood flow regulation device configured to expand to restrict blood flow through the aorta and to contract; a catheter controller unit coupled to the proximal end portion of the catheter and configured to cause the expandable aortic blood flow regulation device to expand and contract in the aorta; one or more sensors configured to measure physiological information indicative of blood flow through the aorta; and a non-transitory computer readable media having instructions stored thereon, characterized in that: the system further includes an automated pump configured to deliver intravenous medication to the patient, and in that the instructions, when executed by one or more processors coupled to the one or more sensors, cause the processors to: compare the measured physiological information with a target physiological range, and in response to determining that the measured physiological information falls outside the target physiological range, automatically adjust, via the catheter controller unit, expansion and contraction of the expandable aortic blood flow regulation device and deliver, via the automated pump, intravenous medication to the patient in order to modulate patient physiology and adjust an amount of blood flow through the aorta. a catheter having a proximal end portion and a distal end portion, the distal end portion configured for placement within an aorta of a patient; an expandable aortic blood flow regulation device disposed on the distal end portion of the catheter for placement within the aorta, the expandable aortic blood flow regulation device configured to expand to restrict blood flow through the aorta and to contract; a catheter controller unit coupled to the proximal end portion of the catheter and configured to cause the expandable aortic blood flow regulation device to expand and contract in the aorta; one or more sensors configured to measure physiological information indicative of blood flow through the aorta; and a non-transitory computer readable media having instructions stored thereon, characterized in that: the system further includes an automated pump configured to deliver intravenous medication to the patient, and in that the instructions, when executed by one or more processors coupled to the one or more sensors, cause the processors to: compare the measured physiological information with a target physiological range, and in response to determining that the measured physiological information falls outside the target physiological range, automatically adjust, via the catheter controller unit, expansion and contraction of the expandable aortic blood flow regulation device and deliver, via the automated pump, intravenous medication to the patient in order to modulate patient physiology and adjust an amount of blood flow through the aorta. the system further includes an automated pump configured to deliver intravenous medication to the patient, and in that the instructions, when executed by one or more processors coupled to the one or more sensors, cause the processors to: compare the measured physiological information with a target physiological range, and in response to determining that the measured physiological information falls outside the target physiological range, automatically adjust, via the catheter controller unit, expansion and contraction of the expandable aortic blood flow regulation device and deliver, via the automated pump, intravenous medication to the patient in order to modulate patient physiology and adjust an amount of blood flow through the aorta. compare the measured physiological information with a target physiological range, and in response to determining that the measured physiological information falls outside the target physiological range, automatically adjust, via the catheter controller unit, expansion and contraction of the expandable aortic blood flow regulation device and deliver, via the automated pump, intravenous medication to the patient in order to modulate patient physiology and adjust an amount of blood flow through the aorta.