mhurhangee/ep-ind-claims huggingface dataset:
A compound capable of modulating or inhibiting the activity of a receptor tyrosine kinase having a structure of Formula I: wherein R 1 is independently H, optionally substituted amino, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkoxy, optionally substituted C 1-6 alkenyl, optionally substituted C 1-6 alkynyl, optionally substituted benzyloxy, cyano, halo, hydroxy, nitro, optionally substituted phenoxy, or mono-, di-, or trifluoromethyl; n is 1, 2, or 3; R 2 is independently H or C 1-3 -alkyl; R 3A is -OR 5A, -NR 2 R 5A, -SR 5A, -C R 5A, -C OR 5A, -C N(R 2)(R 5A), -OC R 5A,-OC OR 5A, -OC NR 2 R 5A, -NR 2 C R 5A, -NR 2 C OR 5A; R 4 is H, -N(R 2) 2, optionally substituted C 1-3 -alkyl, optionally substituted C 1-3 -alkoxy, cyano, halo, hydroxy, nitro, or mono-, di-, or trifluoromethyl; R 5A is -(C 1-4 -alkyl)-X-R 6 -R 7; X is O, S, or N(R 2); R 6 is a bond or C 5-6 aryl or a heteroaryl having 5-6 ring members; R 7 is either (i) a C 1-4 -alkyl substituted by at least one -OH or -C OR 2 or -C N(R 2) 2, or (ii) a heteroaryl having 5 ring members, containing 1-3 heteroatoms and substituted by R 2 and either a halo-substituted benzyloxy or -X-R 8; and R 8 is C 1-3 alkyl substituted by at least one -OH, -COOH, -C O-C 1-4 alkyl, - C N(R 2) 2, or C 1-5 cycloalkyl; or a pharmaceutically acceptable salt form thereof. R 1 is independently H, optionally substituted amino, optionally substituted C 1-6 alkyl, optionally substituted C 1-6 alkoxy, optionally substituted C 1-6 alkenyl, optionally substituted C 1-6 alkynyl, optionally substituted benzyloxy, cyano, halo, hydroxy, nitro, optionally substituted phenoxy, or mono-, di-, or trifluoromethyl; n is 1, 2, or 3; R 2 is independently H or C 1-3 -alkyl; R 3A is -OR 5A, -NR 2 R 5A, -SR 5A, -C R 5A, -C OR 5A, -C N(R 2)(R 5A), -OC R 5A,-OC OR 5A, -OC NR 2 R 5A, -NR 2 C R 5A, -NR 2 C OR 5A; R 4 is H, -N(R 2) 2, optionally substituted C 1-3 -alkyl, optionally substituted C 1-3 -alkoxy, cyano, halo, hydroxy, nitro, or mono-, di-, or trifluoromethyl; R 5A is -(C 1-4 -alkyl)-X-R 6 -R 7; X is O, S, or N(R 2); R 6 is a bond or C 5-6 aryl or a heteroaryl having 5-6 ring members; R 7 is either (i) a C 1-4 -alkyl substituted by at least one -OH or -C OR 2 or -C N(R 2) 2, or (ii) a heteroaryl having 5 ring members, containing 1-3 heteroatoms and substituted by R 2 and either a halo-substituted benzyloxy or -X-R 8; and R 8 is C 1-3 alkyl substituted by at least one -OH, -COOH, -C O-C 1-4 alkyl, - C N(R 2) 2, or C 1-5 cycloalkyl;
A method for determining functional binding activity of an antibody for an agglutinating factor, comprising: (a) incubating an agglutinating factor with an antibody in a well of a culture plate, said well having been coated with a protein or lectin, (b) adding a target object to the well of (a) under conditions permitting agglutination of the target object by the agglutinating factor, and (c) detecting agglutination of the target object on the surface of the well bottom of (b), wherein when agglutination detected in (c) is less than agglutination detected in the absence of the antibody, the antibody is determined to have functional binding activity for the agglutinating factor, and wherein the agglutinating factor is selected from the group consisting of a virus, a virus-like particle and a bacterium. (a) incubating an agglutinating factor with an antibody in a well of a culture plate, said well having been coated with a protein or lectin, (b) adding a target object to the well of (a) under conditions permitting agglutination of the target object by the agglutinating factor, and (c) detecting agglutination of the target object on the surface of the well bottom of (b), wherein when agglutination detected in (c) is less than agglutination detected in the absence of the antibody, the antibody is determined to have functional binding activity for the agglutinating factor, and
A shroud hanger assembly comprising: a shroud hanger; an impingement baffle that is coupled to said shroud hanger, said shroud hanger comprises a cavity and a plurality of cooling passages defined within said shroud hanger, at least two of said cooling passages are coupled together in flow communication via said cavity; the shroud hanger assembly further comprising a screen comprising a plurality of openings extending therethrough to enable air flow to enter said cavity through said screen; characterized in that: each said cooling passage extends from an upstream end face of said shroud hanger through said shroud hanger for channeling cooling air towards said impingement baffle; wherein said screen is coupled to said upstream end face for air flow in an axial direction through said upstream end face. a shroud hanger; an impingement baffle that is coupled to said shroud hanger, said shroud hanger comprises a cavity and a plurality of cooling passages defined within said shroud hanger, at least two of said cooling passages are coupled together in flow communication via said cavity; each said cooling passage extends from an upstream end face of said shroud hanger through said shroud hanger for channeling cooling air towards said impingement baffle;
Actuator means for a heat exchanger valve, said actuator means comprising a thermally expandable medium in a closed volume acting on a plunger, heating means for heating said medium and control means controlling said heating means, characterized in that said heating means has a temperature depending electrical resistance value and said control means uses said resistance value for determining a stroke of said plunger.
A heavy load pneumatic tire for construction vehicles comprising: side lug rows, at both side regions of a tread surface, formed by a plurality of lugs defined by lug grooves each opening to a respective tread end in a tread width direction, and a central block row aligned on a tire equator and formed by a plurality of blocks disposed between positions at 1/4 of a tread surface width from the tire equator; and a directional tread pattern, with a designated rotation direction, formed by circumferential grooves and width direction grooves that define the blocks of the central block row and have groove widths narrower than that of the lug grooves, characterized in that each block of the central block row is defined by circumferential grooves on both sides in the tread width direction, and a distance (HS, HE) from the tire equator to a groove wall in each of the circumferential grooves defining the blocks is larger at a leading edge of each block than at a trailing edge of each block. side lug rows, at both side regions of a tread surface, formed by a plurality of lugs defined by lug grooves each opening to a respective tread end in a tread width direction, and a central block row aligned on a tire equator and formed by a plurality of blocks disposed between positions at 1/4 of a tread surface width from the tire equator; and a directional tread pattern, with a designated rotation direction, formed by circumferential grooves and width direction grooves that define the blocks of the central block row and have groove widths narrower than that of the lug grooves, characterized in that each block of the central block row is defined by circumferential grooves on both sides in the tread width direction, and a distance (HS, HE) from the tire equator to a groove wall in each of the circumferential grooves defining the blocks is larger at a leading edge of each block than at a trailing edge of each block.
A method for manufacturing a water absorption treatment material, comprising: a core portion forming step of forming a core portion in a granular shape; a coating portion forming step of forming a coating portion so as to cover the core portion; and a coating portion removing step of removing a part of the coating portion, and wherein in the coating portion removing step, the coating portion is removed such that the core portion is exposed at a portion where the coating portion is removed. a core portion forming step of forming a core portion in a granular shape; a coating portion forming step of forming a coating portion so as to cover the core portion; and a coating portion removing step of removing a part of the coating portion, and wherein in the coating portion removing step, the coating portion is removed such that the core portion is exposed at a portion where the coating portion is removed.
A method for optimizing the production safety of a membrane-based device for the filtration of a medium for the production of dairy products, the medium being a raw product from which the dairy product is obtained, comprising the steps of: a) taking a sample of the medium that is present in the device for the production of dairy products such as milk, curd, cheese, yogurt, cottage cheese, ricotta, milk protein, milk protein hydrolysate, milk protein concentrate, whey protein, or lactose protein, wherein the dairy product is obtained by separating the medium; b) determining at least one parameter essential for optimizing the production safety of the device; c) transmitting the results obtained in step b) to an external server positioned in a building outside the factory facility where the device is located; d) evaluating the results by the external server; e) If applicable, performing an action based on the evaluation in step d), wherein the method is performed continuously during operation of the device, and in the case of an action, the operation is interrupted, the device is emptied, and the action is performed, wherein the action comprises introducing at least one additive into the device. a) taking a sample of the medium that is present in the device for the production of dairy products such as milk, curd, cheese, yogurt, cottage cheese, ricotta, milk protein, milk protein hydrolysate, milk protein concentrate, whey protein, or lactose protein, wherein the dairy product is obtained by separating the medium; b) determining at least one parameter essential for optimizing the production safety of the device; c) transmitting the results obtained in step b) to an external server positioned in a building outside the factory facility where the device is located; d) evaluating the results by the external server; e) If applicable, performing an action based on the evaluation in step d), wherein the method is performed continuously during operation of the device, and in the case of an action, the operation is interrupted, the device is emptied, and the action is performed, wherein the action comprises introducing at least one additive into the device.
A composition comprising a polyether-based polymer and a nano-carbon material, the polyether-based polymer containing oxirane monomer units at least part of which are oxirane monomer units each having a cationic group wherein the oxirane monomer units each having a cationic group of the polyether-based polymer are each a unit represented by the following formula: where A + is a cationic group or a cationic group containing group, and X - is a counter anion and wherein the nano-carbon material is a single-walled carbon nanotube.
A method to be executed at least in part in a computing device for automated recovery and escalation of alerts in distributed systems, the method comprising: detecting, by a monitoring engine, a problem associated with at least one of a device and a software application within a distributed system; transmitting, by the monitoring engine, an alert based on the detected problem to an automation engine; receiving the alert associated with a detected problem from the monitoring engine at the automation engine; the method further comprising the following steps performed by the automation engine; collecting diagnostic information associated with the detected problem; attempt to map the alert to a recovery action, wherein the automation engine performs a wild card search of a troubleshoot database to determine multiple recovery actions in response to the received alert, the troubleshoot database storing profiles of alerts matched to recovery actions further classified by device or software programs; if the alert is mapped to a recovery action, perform the recovery action, wherein, if the alert matches several wild card mappings, only the most specific mapping is applied; else escalate the alert to a designee together with the collected diagnostic information; and update, by employing the collected diagnostic information, records associated with alert - recovery action mapping; the method further comprising the monitoring engine receiving a feedback response from a device or software program after execution of the recovery action and passing the response on to the automation engine; in response, the automation engine updating the troubleshoot database. detecting, by a monitoring engine, a problem associated with at least one of a device and a software application within a distributed system; transmitting, by the monitoring engine, an alert based on the detected problem to an automation engine; receiving the alert associated with a detected problem from the monitoring engine at the automation engine; the method further comprising the following steps performed by the automation engine; collecting diagnostic information associated with the detected problem; attempt to map the alert to a recovery action, wherein the automation engine performs a wild card search of a troubleshoot database to determine multiple recovery actions in response to the received alert, the troubleshoot database storing profiles of alerts matched to recovery actions further classified by device or software programs; if the alert is mapped to a recovery action, perform the recovery action, wherein, if the alert matches several wild card mappings, only the most specific mapping is applied; else escalate the alert to a designee together with the collected diagnostic information; and update, by employing the collected diagnostic information, records associated with alert - recovery action mapping; the method further comprising the monitoring engine receiving a feedback response from a device or software program after execution of the recovery action and passing the response on to the automation engine; in response, the automation engine updating the troubleshoot database.
A surface-coated cutting tool comprising a base material and a coating formed on the base material, said base material containing C, said coating including one or two or more layers, a layer among said layers that abuts on said base material being a TiN layer, said TiN layer containing C together with TiN, wherein C has a concentration distribution in a thickness direction of said TiN layer, characterized in that the concentration of C increases in the vicinity of the surface of said base material, said concentration distribution has a distribution where the concentration of C decreases in the direction from said base material, then reaches a local minimum, and thereafter increases in the direction toward the surface of said coating, and said concentration distribution has a difference between a maximum concentration and a minimum concentration of C of 10 atomic % or more, wherein said C in said TiN layer has a maximum concentration of 30 atomic % or less.
Molded article comprising popcorn substantially surrounded by a polymer and further a binder, wherein the summed amount of polymer and binder is ≤ 20% (wt./wt.) based on the molded article, wherein the polymer is a hydrophobic polymer, wherein the popcorn has a particle size distribution in which the fat content of the popcorn before processing is ≤ 10 (wt.-)%.
A pulsation damper for a condensate pump comprising: a housing defining a fluid chamber having a liquid inlet connectable to an outlet of the condensate pump, an air inlet, and a liquid outlet, and a damper element connected to the liquid inlet and projecting into the fluid chamber, forming a pulsation dampening channel, wherein the air inlet includes a one-way valve configured to selectively introduce air into the housing to maintain a first air pocket within the fluid chamber as liquid flows through the fluid chamber from the liquid inlet to the liquid outlet, wherein the liquid outlet is located outside the first air pocket, wherein the air pocket is configured to dissipate pulsations within liquid entering the housing at the liquid inlet prior to the liquid discharging via the liquid outlet. a housing defining a fluid chamber having a liquid inlet connectable to an outlet of the condensate pump, an air inlet, and a liquid outlet, and a damper element connected to the liquid inlet and projecting into the fluid chamber, forming a pulsation dampening channel, wherein the air inlet includes a one-way valve configured to selectively introduce air into the housing to maintain a first air pocket within the fluid chamber as liquid flows through the fluid chamber from the liquid inlet to the liquid outlet, wherein the liquid outlet is located outside the first air pocket, wherein the air pocket is configured to dissipate pulsations within liquid entering the housing at the liquid inlet prior to the liquid discharging via the liquid outlet.
Aerodynamic deflector (30; 50) intended to be mounted under the body base of a motor vehicle, comprising a sole (31; 51) intended to cover at least a portion of this body base and first pre-holding means (34; 54) arranged at a first longitudinal end of said sole (31; 51) and capable of cooperating with complementary means (11; 12) provided on said base so as to ensure pre-holding of this sole deflector (30; 50) on said underframe in a position suspended vertically, said first pre-holding means (34; 54) being further configured so that said deflector (30; 50) can freely pivot relative to said underframe about a transverse axis (A1; A2) so as to allow it to be folded in horizontal position against this underframe; wherein it comprises second pre-holding means comprising a main snap-fastening member (37; 57) projecting from the upper face of the transverse edge (31A; 51A) of said sole (31; 51) extending along the second longitudinal end of this sole (31; 51), said main snap-fastening member (37; 57) being intended, when said deflector (30; 50) is folded down in a horizontal position of assembly line against said base, to cooperate by snap-fastening with the edge of a corresponding hole or cut (22; 26) made on a wall of said base.
A security device having a region of piezochromic material, and an integrated relief structure and being characterized in that it comprises structural modulations in the thickness of the relief structure, the device being arranged such that when the piezochromic material and relief structure are together subjected to a stress an optical effect is generated in the piezochromic material by the said stress causing localised modulations in the deformation of the piezochromic material which are representative of the structural modulations of the relief structure, wherein the optical effect is modulated in accordance with the said structural modulations of the relief structure such that the optical effect is representative of the said relief of the integrated relief structure and wherein the device comprises first and second discrete absorbing regions whereby at least one of the said first and second absorbing regions comprises the relief structure.
An arithmetic processing device comprising: a fixed-point operator that executes an operation on a fixed-point number; a floating-point operator that executes an operation on a floating-point number; a first converter that converts a result of the operation by the floating-point operator to a fixed-point number having a second bit width larger than a first bit width; a statistical information acquirer that acquires statistical information of any of the fixed-point number output by the fixed-point operator and the fixed-point number output by the first converter; and a second converter that converts, to a fixed-point number having the first bit width, the fixed-point number that has been output by the fixed-point operator or by the first converter and of which the statistical information has been acquired. a fixed-point operator that executes an operation on a fixed-point number; a floating-point operator that executes an operation on a floating-point number; a first converter that converts a result of the operation by the floating-point operator to a fixed-point number having a second bit width larger than a first bit width; a statistical information acquirer that acquires statistical information of any of the fixed-point number output by the fixed-point operator and the fixed-point number output by the first converter; and a second converter that converts, to a fixed-point number having the first bit width, the fixed-point number that has been output by the fixed-point operator or by the first converter and of which the statistical information has been acquired.
Punching device for punching a sheet of corrugated cardboard of a specified thickness, comprising a support plate in which at least one punching line is fastened in such a way that it protrudes perpendicularly to the support plate and comprises a punching edge at its free, protruding end, a holding-down surface that extends in parallel with the punching edge being arranged adjacently to at least one longitudinal side of the punching line, the distance between the holding-down surface and the support plate being shorter than the distance between the punching edge and the support plate, characterised in that - the distance between the punching edge and the holding-down surface is between 0.40 mm and 2.00 mm, depending on the compressed thickness of the sheet to be punched, and - the holding-down surface consists of a non-resilient hard material. - the distance between the punching edge and the holding-down surface is between 0.40 mm and 2.00 mm, depending on the compressed thickness of the sheet to be punched, and - the holding-down surface consists of a non-resilient hard material.
Fiber laying machine for producing laid fiber scrims, having - a machine frame, - an x carriage which is linearly displaceable in a horizontal x direction, - a tool table for positioning a mold, said tool table being arranged on the x carriage and being pivotable about a vertically extending pivot axis, - a fiber laying head for laying fibers on a mold, said fiber laying head being arranged above the tool table in a vertical z direction, - a fiber supply unit for supplying the fibers to be laid by the fiber laying head, wherein the fiber laying head is linearly displaceable by means of a y carriage in a horizontal y direction extending transversely to the x direction, wherein the fiber laying head and the y carriage are arranged on the machine frame, characterized in that the machine frame has a machine bed which extends in the x and y direction and on which the x carriage is linearly displaceable or on which x guide rails are arranged. - a machine frame, - an x carriage which is linearly displaceable in a horizontal x direction, - a tool table for positioning a mold, said tool table being arranged on the x carriage and being pivotable about a vertically extending pivot axis, - a fiber laying head for laying fibers on a mold, said fiber laying head being arranged above the tool table in a vertical z direction, - a fiber supply unit for supplying the fibers to be laid by the fiber laying head,
Radial shaft seal with at least one sealing lip of elastomeric material, which on its inner side facing the shaft to be sealed has a first circumferential ring, which in the installation position rests against the shaft and seals against the medium side, return elements (21, 22) arranged over the circumference of the sealing lip, which are provided on the side of the first ring facing the air side and convey leakage medium towards the medium side independently of the direction of rotation of the shaft, and at least one second circulating ring which is provided on the side of the first ring facing the air side and has further return elements on its air side, characterised in that the second ring is provided on its side facing the medium side with bulges which are arranged distributed over its circumference and extend in the direction of the first ring.