A method for detecting an analyte in a sample of a body fluid, the method comprising the following steps: a) providing at least one optical measurement curve, wherein the optical measurement curve contains a plurality of measurement values recorded by monitoring a time development of at least one measurement value indicating a progress of a detection reaction of at least one test substance and the sample of a body fluid, wherein the measurement values contained in the optical measurement curve are acquired at differing points in time, wherein the detection reaction is known to be influenced by a set of state variables, each state variable characterizing at least one of a state of the sample of the body fluid and a condition of the detection reaction; b) providing a set of at least two different evaluation rules, each evaluation rule being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={X i} i=1...N from the optical measurement curve, the set of characteristic values comprising at least one first characteristic value being derived from the optical measurement curve by using at least one first evaluation rule from the set of evaluation rules and at least one second characteristic value being derived from the optical measurement curve by using at least one second evaluation rule from the set of evaluation rules, the second evaluation rule being different from the first evaluation rule; c) performing at least one multivariate analysis of the at least one first characteristic value and the at least one second characteristic value by using at least one predetermined multivariate evaluation algorithm, the multivariate evaluation algorithm being an algorithm adapted to derive at least one result from at least two variables, wherein the at least one first characteristic value and the at least one second characteristic value are used as the at least two variables, thereby deriving at least one estimate value for at least one target variable Y of the state variables; d) determining a concentration of the at least one analyte by using the at least one target variable Y. a) providing at least one optical measurement curve, wherein the optical measurement curve contains a plurality of measurement values recorded by monitoring a time development of at least one measurement value indicating a progress of a detection reaction of at least one test substance and the sample of a body fluid, wherein the measurement values contained in the optical measurement curve are acquired at differing points in time, wherein the detection reaction is known to be influenced by a set of state variables, each state variable characterizing at least one of a state of the sample of the body fluid and a condition of the detection reaction; b) providing a set of at least two different evaluation rules, each evaluation rule being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={X i} i=1...N from the optical measurement curve, the set of characteristic values comprising at least one first characteristic value being derived from the optical measurement curve by using at least one first evaluation rule from the set of evaluation rules and at least one second characteristic value being derived from the optical measurement curve by using at least one second evaluation rule from the set of evaluation rules, the second evaluation rule being different from the first evaluation rule; c) performing at least one multivariate analysis of the at least one first characteristic value and the at least one second characteristic value by using at least one predetermined multivariate evaluation algorithm, the multivariate evaluation algorithm being an algorithm adapted to derive at least one result from at least two variables, wherein the at least one first characteristic value and the at least one second characteristic value are used as the at least two variables, thereby deriving at least one estimate value for at least one target variable Y of the state variables; d) determining a concentration of the at least one analyte by using the at least one target variable Y.