A variable angle orthopedic plate, the plate comprising: an upper surface; a bone facing surface; at least one variable angle through hole between the upper surface and the bone facing surface, the hole having a generally cylindrical shape with a central hole axis and comprising a single continuous thread, an apex of which comprising a thread peak that defines a central hole aperture of radius (r aperture), and a thread trough defining a total hole radius of (r hole), wherein the thread has at least two indentations and two peaks spaced apart at regular intervals along its length, each indentation having a radius (r indent), wherein r aperture < r indent < r hole, the plate being characterized in that the thread peak varies along the length of the thread, the radius of the central hole aperture (r aperture) varying between a maximum (r aperture-max) and a minimum (r aperture-min) value, said maximum value (r aperture-max) being less than the total radius of the hole (r aperture-max < r hole), wherein the thread spans at least two turns around the circumference of the hole, each turn comprising at least: a first region having a maximum thread height (h max1), a second region having a maximum thread height (h max2), and a third region having a minimum thread height (h min3) positioned between the first region and the second region, wherein h max1 > h min3, h max2 > h min3, and h min3 > 0 for each turn independently, the height being calculated as the distance between the thread apex and the thread trough, and wherein the variable angle through hole is operable to engage a threaded head of an orthopedic screw at a first angle aligned with the central hole axis and at least one other angle. an upper surface; a bone facing surface; at least one variable angle through hole between the upper surface and the bone facing surface, the hole having a generally cylindrical shape with a central hole axis and comprising a single continuous thread, an apex of which comprising a thread peak that defines a central hole aperture of radius (r aperture), and a thread trough defining a total hole radius of (r hole), wherein the thread has at least two indentations and two peaks spaced apart at regular intervals along its length, each indentation having a radius (r indent), wherein r aperture < r indent < r hole, the plate being characterized in that the thread peak varies along the length of the thread, the radius of the central hole aperture (r aperture) varying between a maximum (r aperture-max) and a minimum (r aperture-min) value, said maximum value (r aperture-max) being less than the total radius of the hole (r aperture-max < r hole), wherein the thread spans at least two turns around the circumference of the hole, each turn comprising at least: a first region having a maximum thread height (h max1), a second region having a maximum thread height (h max2), and a third region having a minimum thread height (h min3) positioned between the first region and the second region, wherein h max1 > h min3, h max2 > h min3, and h min3 > 0 for each turn independently, the height being calculated as the distance between the thread apex and the thread trough, and a first region having a maximum thread height (h max1), a second region having a maximum thread height (h max2), and a third region having a minimum thread height (h min3) positioned between the first region and the second region, wherein h max1 > h min3, h max2 > h min3, and h min3 > 0 for each turn independently, the height being calculated as the distance between the thread apex and the thread trough, and wherein the variable angle through hole is operable to engage a threaded head of an orthopedic screw at a first angle aligned with the central hole axis and at least one other angle.