A system for mapping the locations of captured images of skin tissue having a lesion comprising a tracing guide sheet providing a guide member and a template device - whereas the guide member comprises features to facilitate the spatial alignment of the guide member in the form of at least a grid comprising at least x and y orthogonal axis (26a, 26b) extending along the grid in which a center or fiducial mark is provided on the guide member defining the center of the x and y axes in such a coordinate system and optionally further comprising diagonal axes along said grid through said center; - whereas the template device is movable along the guide member, when the guide member is temporarily coupled or affixed to the tissue; - whereas the template device having a first aperture located over the surface of the guide member and a second aperture located over the tissue having at least the lesion disposed adjacent the guide member; - whereas the template device has a first dimension extending longitudinally along the template device extending centrally through the first and second aperture and to be aligned parallel to the x axis of the grid of the guide member; - whereas the first aperture and the second aperture of the template device each have a centrally oriented second dimension orthogonal to the first dimension to be aligned parallel to the y axis of the grid of the guide member; - whereas lines, grooves, or channels (38, 39b) are provided along the front of the template device extending along the first dimension and parallel second dimensions for use in aligning the guide member to the template device to provide the spatial correlation to the guide member; - whereas the tracing guide sheet is configured to be used to establish the spatial correlation between the lesion and the grid and the axes on the guide member, to enable operation of the template device to guide imaging by a microscope along the guide member to selected or mapped locations; whereas the tracing guide sheet has two portions (17, 18) with one portion providing the guide member, and whereas the portions may fold over each other so that both portions extend along common orthogonal dimensions or axes in folded state. - whereas the guide member comprises features to facilitate the spatial alignment of the guide member in the form of at least a grid comprising at least x and y orthogonal axis (26a, 26b) extending along the grid in which a center or fiducial mark is provided on the guide member defining the center of the x and y axes in such a coordinate system and optionally further comprising diagonal axes along said grid through said center; - whereas the template device is movable along the guide member, when the guide member is temporarily coupled or affixed to the tissue; - whereas the template device having a first aperture located over the surface of the guide member and a second aperture located over the tissue having at least the lesion disposed adjacent the guide member; - whereas the template device has a first dimension extending longitudinally along the template device extending centrally through the first and second aperture and to be aligned parallel to the x axis of the grid of the guide member; - whereas the first aperture and the second aperture of the template device each have a centrally oriented second dimension orthogonal to the first dimension to be aligned parallel to the y axis of the grid of the guide member; - whereas lines, grooves, or channels (38, 39b) are provided along the front of the template device extending along the first dimension and parallel second dimensions for use in aligning the guide member to the template device to provide the spatial correlation to the guide member; - whereas the tracing guide sheet is configured to be used to establish the spatial correlation between the lesion and the grid and the axes on the guide member, to enable operation of the template device to guide imaging by a microscope along the guide member to selected or mapped locations; whereas the tracing guide sheet has two portions (17, 18) with one portion providing the guide member, and whereas the portions may fold over each other so that both portions extend along common orthogonal dimensions or axes in folded state.