mhurhangee/ep-ind-claims huggingface dataset:
A genetically modified CD34+ hematopoietic stem cell comprising: a pair of zinc finger nucleases, the pair comprising: (i) a first zinc finger nuclease that binds to a target site as shown in SEQ ID NO:5, the first ZFN comprising the following recognition helix regions: F1: LRHHLTR (SEQ ID NO:11); F2: QSGTRKT (SEQ ID NO:12); F3: RSDNLST (SEQ ID NO:13); F4: DSANRIK (SEQ ID NO:14); F5: LRHHLTR (SEQ ID NO:11); and F6: QSGNLHV (SEQ ID NO:15); and (ii) a second zinc finger nuclease that binds to a target site as shown in SEQ ID NO:4, the second ZFN comprising the following recognition helix regions: F1: AMQTLRV (SEQ ID NO:16); F2: DRSHLAR (SEQ ID NO:7); F3: RSDNLSE (SEQ ID NO:8); F4: ASKTRKN (SEQ ID NO:9); and F5: TSSDRKK (SEQ ID NO:17) or VYEGLKK (SEQ ID NO:18); and a donor sequence comprising a sequence as shown in SEQ ID NO: 19 or SEQ ID NO: 21, wherein the donor sequence is inserted into an endogenous aberrant human beta-hemoglobin (Hbb) gene following targeted cleavage by the pair of zinc finger nucleases, thereby correcting the sequence of the Hbb gene, and wherein the aberrant Hbb gene comprises an intervening sequence 1, mutation number 1 (IVS1-1) mutation. a pair of zinc finger nucleases, the pair comprising: (i) a first zinc finger nuclease that binds to a target site as shown in SEQ ID NO:5, the first ZFN comprising the following recognition helix regions: F1: LRHHLTR (SEQ ID NO:11); F2: QSGTRKT (SEQ ID NO:12); F3: RSDNLST (SEQ ID NO:13); F4: DSANRIK (SEQ ID NO:14); F5: LRHHLTR (SEQ ID NO:11); and F6: QSGNLHV (SEQ ID NO:15); and (ii) a second zinc finger nuclease that binds to a target site as shown in SEQ ID NO:4, the second ZFN comprising the following recognition helix regions: F1: AMQTLRV (SEQ ID NO:16); F2: DRSHLAR (SEQ ID NO:7); F3: RSDNLSE (SEQ ID NO:8); F4: ASKTRKN (SEQ ID NO:9); and F5: TSSDRKK (SEQ ID NO:17) or VYEGLKK (SEQ ID NO:18); (i) a first zinc finger nuclease that binds to a target site as shown in SEQ ID NO:5, the first ZFN comprising the following recognition helix regions: F1: LRHHLTR (SEQ ID NO:11); F2: QSGTRKT (SEQ ID NO:12); F3: RSDNLST (SEQ ID NO:13); F4: DSANRIK (SEQ ID NO:14); F5: LRHHLTR (SEQ ID NO:11); and F6: QSGNLHV (SEQ ID NO:15); and F1: LRHHLTR (SEQ ID NO:11); F2: QSGTRKT (SEQ ID NO:12); F3: RSDNLST (SEQ ID NO:13); F4: DSANRIK (SEQ ID NO:14); F5: LRHHLTR (SEQ ID NO:11); and F6: QSGNLHV (SEQ ID NO:15); and (ii) a second zinc finger nuclease that binds to a target site as shown in SEQ ID NO:4, the second ZFN comprising the following recognition helix regions: F1: AMQTLRV (SEQ ID NO:16); F2: DRSHLAR (SEQ ID NO:7); F3: RSDNLSE (SEQ ID NO:8); F4: ASKTRKN (SEQ ID NO:9); and F5: TSSDRKK (SEQ ID NO:17) or VYEGLKK (SEQ ID NO:18); F1: AMQTLRV (SEQ ID NO:16); F2: DRSHLAR (SEQ ID NO:7); F3: RSDNLSE (SEQ ID NO:8); F4: ASKTRKN (SEQ ID NO:9); and F5: TSSDRKK (SEQ ID NO:17) or VYEGLKK (SEQ ID NO:18); and a donor sequence comprising a sequence as shown in SEQ ID NO: 19 or SEQ ID NO: 21,
A method of measuring a sample, in which: an acoustic wave is generated in the sample; the generated wave is detected; generation is effected at a plurality of values of a frequency of generation, to vary the efficiency of generation, the detected wave is measured to identify the efficiency of generation at each value of the frequency of generation, thereby to provide a measurement of the acoustic velocity at the generation site, and the method is executed at a plurality of generation sites (12, 20) on the sample, to provide a set of spatially resolved measurements of the sample, wherein the amplitude of the wave is detected and wherein the acoustic velocity at each generation site is calculated from the value which corresponds with the peak detected amplitude. an acoustic wave is generated in the sample; the generated wave is detected; generation is effected at a plurality of values of a frequency of generation, to vary the efficiency of generation, the detected wave is measured to identify the efficiency of generation at each value of the frequency of generation, thereby to provide a measurement of the acoustic velocity at the generation site, and the method is executed at a plurality of generation sites (12, 20) on the sample, to provide a set of spatially resolved measurements of the sample, wherein the amplitude of the wave is detected and wherein the acoustic velocity at each generation site is calculated from the value which corresponds with the peak detected amplitude.
An object information acquiring apparatus comprising: a supporting unit configured to be capable of holding a liquid acoustic matching member; a plurality of receiving elements each supported on the supporting unit to receive an acoustic wave propagated from an object via the acoustic matching member and output an electrical signal; a scanning unit that changes a relative position of the supporting unit and the object by moving the supporting unit; a controlling unit that controls a velocity of movement of the supporting unit performed by the scanning unit; and a processing unit that acquires specific information of an inside of the object based on the electrical signal, wherein the scanning unit moves the supporting unit on a path having portions of different curvatures, and the controlling unit controls the movement velocity in accordance with a magnitude of the curvature. a supporting unit configured to be capable of holding a liquid acoustic matching member; a plurality of receiving elements each supported on the supporting unit to receive an acoustic wave propagated from an object via the acoustic matching member and output an electrical signal; a scanning unit that changes a relative position of the supporting unit and the object by moving the supporting unit; a controlling unit that controls a velocity of movement of the supporting unit performed by the scanning unit; and a processing unit that acquires specific information of an inside of the object based on the electrical signal, wherein the scanning unit moves the supporting unit on a path having portions of different curvatures, and the controlling unit controls the movement velocity in accordance with a magnitude of the curvature.
An apparatus comprising: processing means adapted to perform frequency domain acknowledgement/negative acknowledgement, hereafter referred to as ACK/NACK, bundling for downlink data transmission across component carriers within a user equipment reception bandwidth; generating means adapted to generate a bundled ACK/NAK value corresponding to at least one code word of the downlink data transmission on the basis of the performed ACK/NAK bundling; and transmitting means adapted to indicate in an ACK/NACK resource to be transmitted on an uplink control channel, information relating to the generated bundled ACK/NAK value and the number of detected resource allocation grants in downlink across the component carriers within the user equipment reception bandwidth. processing means adapted to perform frequency domain acknowledgement/negative acknowledgement, hereafter referred to as ACK/NACK, bundling for downlink data transmission across component carriers within a user equipment reception bandwidth; generating means adapted to generate a bundled ACK/NAK value corresponding to at least one code word of the downlink data transmission on the basis of the performed ACK/NAK bundling; and transmitting means adapted to indicate in an ACK/NACK resource to be transmitted on an uplink control channel, information relating to the generated bundled ACK/NAK value and the number of detected resource allocation grants in downlink across the component carriers within the user equipment reception bandwidth.
An article comprising a film layer, the film layer comprising a polymer blend comprising a thermoplastic polyurethane and a cellulose ester; and an ink layer adjacent to at least one surface of the film, wherein the film layer is made by a hot melt process.
An antenna structure comprising: a first port; a second port; and a single radiator connected to both the first and second ports (202, 203), the single radiator being operable to simultaneously transceive in: a symmetrical excited mode in which current flows symmetrically through the single radiator to or from the first port, thereby causing the single radiator to resonate at a first resonant frequency; and an asymmetrical excited mode in which current flows asymmetrically through the single radiator to or from the second port, thereby causing the single radiator to resonate at a second resonant frequency, wherein the single radiator comprises: a first element, the first element being elongate and linear; a second element, the second element being elongate, linear, and parallel to the first element; and arm connectors connecting the first element to the second element; wherein the second port comprises two second port feedlines connected to the second element in a symmetrical arrangement; wherein the antenna structure is configured to feed a signal being transmitted or received via the second port as a differential signal along the two second port feedlines. a first port; a second port; and a single radiator connected to both the first and second ports (202, 203), the single radiator being operable to simultaneously transceive in: a symmetrical excited mode in which current flows symmetrically through the single radiator to or from the first port, thereby causing the single radiator to resonate at a first resonant frequency; and an asymmetrical excited mode in which current flows asymmetrically through the single radiator to or from the second port, thereby causing the single radiator to resonate at a second resonant frequency, a symmetrical excited mode in which current flows symmetrically through the single radiator to or from the first port, thereby causing the single radiator to resonate at a first resonant frequency; and an asymmetrical excited mode in which current flows asymmetrically through the single radiator to or from the second port, thereby causing the single radiator to resonate at a second resonant frequency, wherein the single radiator comprises: a first element, the first element being elongate and linear; a second element, the second element being elongate, linear, and parallel to the first element; and arm connectors connecting the first element to the second element; a first element, the first element being elongate and linear; a second element, the second element being elongate, linear, and parallel to the first element; and arm connectors connecting the first element to the second element; wherein the second port comprises two second port feedlines connected to the second element in a symmetrical arrangement; wherein the antenna structure is configured to feed a signal being transmitted or received via the second port as a differential signal along the two second port feedlines.
A vehicle comprising a power transmission path including a meshed gear disposed in the power transmission path between an engine and drive wheels and made up of a pair of gears (22, 64) meshed with each other, wherein at least one gear making up the meshed gear has a cylindrical shape, the one gear formed in the cylindrical shape has a dynamic damper disposed on an outer circumferential side of the one gear, and the dynamic damper is made up of a ring-shaped mass member disposed on the outer circumferential side of the one gear and an elastic member connecting the mass member and an outer circumferential portion of the one gear, characterized in that the one gear is rotatably supported by bearings (69, 71) disposed on an inner circumferential side of the one gear.
An apparatus for igniting fluid fuel in a combustion chamber, the apparatus comprising: at least one elongate member that defines an internal fuel channel for carrying fuel supplied thereto; a conductive wire loop including a heater coil and an igniter coil, said heater coil separate and distinct from and operably disposed inside of said internal fuel channel for resistive heating of fluid fuel flowing through said internal fuel channel, and said ignitor coil operably disposed downstream of said internal fuel channel for igniting the fluid fuel exiting said internal fuel channel, wherein, said heater coil and said ignitor coil are electronically coupled in series, said heater coil is in direct contact with the fluid fuel flowing through said internal fuel channel, and said ignitor coil is in direct contact with fuel exiting said internal fuel channel. at least one elongate member that defines an internal fuel channel for carrying fuel supplied thereto; a conductive wire loop including a heater coil and an igniter coil, said heater coil separate and distinct from and operably disposed inside of said internal fuel channel for resistive heating of fluid fuel flowing through said internal fuel channel, and said ignitor coil operably disposed downstream of said internal fuel channel for igniting the fluid fuel exiting said internal fuel channel, wherein, said heater coil and said ignitor coil are electronically coupled in series, said heater coil is in direct contact with the fluid fuel flowing through said internal fuel channel, and said ignitor coil is in direct contact with fuel exiting said internal fuel channel.
A method for transporting audio data between a first network element (110, 500) and a second network element, the method comprising: dividing, by the first network element, multichannel audio data by channel into a plurality of individual channels; determining, by the first network element, whether an entirety of an individual channel from the plurality of channels is an active channel for each individual channel from the plurality of channels, wherein detecting inactive channels is related to the active channel determination; packaging, by the first network element, only each of the plurality of active individual channels, and excluding any inactive individual channels into a packet; and transmitting, by the first network element to the second network element, the packet using bandwidth that is the initially reserved bandwidth for the audio data. dividing, by the first network element, multichannel audio data by channel into a plurality of individual channels; determining, by the first network element, whether an entirety of an individual channel from the plurality of channels is an active channel for each individual channel from the plurality of channels, wherein detecting inactive channels is related to the active channel determination; packaging, by the first network element, only each of the plurality of active individual channels, and excluding any inactive individual channels into a packet; and transmitting, by the first network element to the second network element, the packet using bandwidth that is the initially reserved bandwidth for the audio data.
Autonomous cooking apparatus for food comprising a base body, a lid defining with said base body a cooking chamber, a container, disposed in the base body and suitable to contain the food to be cooked, a mixing device, comprising at least a mixing blade suitable to cooperate with a cooking plane of said container, to mix said food, said mixing device being connected to a drive member configured to make it rotate with respect to said container around a central axis of rotation, a heating device configured to heat air in said cooking chamber to a desired temperature and a ventilation device configured to make the air circulate, characterized in that said mixing device is provided with means to receive the hot air along said central axis of rotation comprising an entrance aperture, and with exit means of the hot air (27, 29) comprising exit apertures associated with at least part of said mixing blade, wherein said autonomous apparatus comprises a conveying device disposed between said ventilation device and said means to receive the hot air.
A weeding system for an agricultural weeding vehicle, comprising: * at least one camera adapted to be mounted on an agricultural vehicle to acquire an image of a portion of a field while said agricultural vehicle is travelling in said field, said image comprising a matrix of pixel values, * a spraying unit adapted to be mounted on said agricultural vehicle, * a control unit adapted to receive running mode nighttime images from said camera, to apply to the received nighttime images in a running mode a trained weed recognition algorithm to generate a weed species detection signal and selectively cause the spraying of a chemical agent by the spraying unit on the basis of said weed species detection signal, the control unit being adapted to execute, in a training mode, a training of the weed recognition algorithm, the training being applied on a set of reference images labeled according to the effective presence or not of weed species in said images, each of said reference images comprising a pair of a so-called nighttime image and a so-called daytime image of the same scene taken with the same camera, said labeling being performed on the daytime images and applied to the corresponding nighttime images, and the training being applied on the nighttime images labeled accordingly. * at least one camera adapted to be mounted on an agricultural vehicle to acquire an image of a portion of a field while said agricultural vehicle is travelling in said field, said image comprising a matrix of pixel values, * a spraying unit adapted to be mounted on said agricultural vehicle, * a control unit adapted to receive running mode nighttime images from said camera, to apply to the received nighttime images in a running mode a trained weed recognition algorithm to generate a weed species detection signal and selectively cause the spraying of a chemical agent by the spraying unit on the basis of said weed species detection signal, the control unit being adapted to execute, in a training mode, a training of the weed recognition algorithm, the training being applied on a set of reference images labeled according to the effective presence or not of weed species in said images, each of said reference images comprising a pair of a so-called nighttime image and a so-called daytime image of the same scene taken with the same camera, said labeling being performed on the daytime images and applied to the corresponding nighttime images, and the training being applied on the nighttime images labeled accordingly.
A system comprising: an implant positioning device including a tracking component, a communication link for receiving control signals, and an end effector for removably coupling to an implant component; a tracking system including a tracking sensor, the tracking system adapted to monitor, in real-time, three dimensional position and orientation of the implant positioning device and an implant host; a control system, the control system including: a communication interface coupled to the implant positioning device via the communication link and the tracking system, the communication interface adapted to send control signals to the implant positioning device and adapted to receive tracking information identifying a current implant positioning device position and a current implant host position; one or more processors coupled to a memory device, the memory device including instructions that, when executed by the one or more processors, cause the control system to generate control signals based on the tracking information and an implant plan, the control signals controlling operation of the implant positioning device to assist a surgeon in positioning an implant according to the implant plan, characterized in that the instructions to generate control signals include additional instructions to generate signals to control amplitude and frequency of impacts delivered by the implant positioning device. an implant positioning device including a tracking component, a communication link for receiving control signals, and an end effector for removably coupling to an implant component; a tracking system including a tracking sensor, the tracking system adapted to monitor, in real-time, three dimensional position and orientation of the implant positioning device and an implant host; a control system, the control system including: a communication interface coupled to the implant positioning device via the communication link and the tracking system, the communication interface adapted to send control signals to the implant positioning device and adapted to receive tracking information identifying a current implant positioning device position and a current implant host position; one or more processors coupled to a memory device, the memory device including instructions that, when executed by the one or more processors, cause the control system to generate control signals based on the tracking information and an implant plan, the control signals controlling operation of the implant positioning device to assist a surgeon in positioning an implant according to the implant plan, characterized in that the instructions to generate control signals include additional instructions to generate signals to control amplitude and frequency of impacts delivered by the implant positioning device.
A communication method comprising the steps of: determining, by a first wireless communication apparatus, that a second wireless communication apparatus is contactable via wireless communication before a step of transmitting; transmitting, by means of the first wireless communication apparatus, disclosable personal information to the second wireless communication apparatus, wherein the personal information is a name or an address of a person who is not a user of a communication apparatus (1a, 1x) in which the personal information is held; receiving, by means of the second wireless communication apparatus, the personal information and searching, by means of the second wireless communication apparatus, whether or not personal information having a same content as the received personal information exists in the second wireless communication apparatus, wherein said searching by means of said second wireless communication apparatus further comprises, when identifying the presence of personal information having a same content as the received personal information and which is set as not being disclosable, notifying the user of the second wireless communication apparatus of the identification of not disclosable personal information; and notifying, by means of the second wireless communication apparatus, the first wireless communication apparatus of a search result, wherein the search result indicates the presence or absence of the personal information having the same content as the received personal information. determining, by a first wireless communication apparatus, that a second wireless communication apparatus is contactable via wireless communication before a step of transmitting; transmitting, by means of the first wireless communication apparatus, disclosable personal information to the second wireless communication apparatus, wherein the personal information is a name or an address of a person who is not a user of a communication apparatus (1a, 1x) in which the personal information is held; receiving, by means of the second wireless communication apparatus, the personal information and searching, by means of the second wireless communication apparatus, whether or not personal information having a same content as the received personal information exists in the second wireless communication apparatus, wherein said searching by means of said second wireless communication apparatus further comprises, when identifying the presence of personal information having a same content as the received personal information and which is set as not being disclosable, notifying the user of the second wireless communication apparatus of the identification of not disclosable personal information; and notifying, by means of the second wireless communication apparatus, the first wireless communication apparatus of a search result, wherein the search result indicates the presence or absence of the personal information having the same content as the received personal information.