mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition for use in a method of inducing immune tolerance in a human subject suffering from or at risk of developing an autoimmune disease, disorder or condition, the pharmaceutical composition comprising an enucleated erythroid cell expressing an exogenous antigen, wherein the pharmaceutical composition is administered in an amount effective to induce immune tolerance in the subject to the antigen mediating the autoimmune disease, disorder or condition; and wherein: the exogenous antigen is bound to the cell membrane of the enucleated erythroid cell; and the exogenous antigen is a fusion or a chimera polypeptide, wherein the fusion or chimera polypeptide is a polypeptide that is derived from the combination of two or more amino acid sequences that are not found together in nature. the exogenous antigen is bound to the cell membrane of the enucleated erythroid cell; and the exogenous antigen is a fusion or a chimera polypeptide, wherein the fusion or chimera polypeptide is a polypeptide that is derived from the combination of two or more amino acid sequences that are not found together in nature.
A compound comprising a modified antisense oligonucleotide consisting of 10 to 30 linked nucleosides complementary to a non-repeat region of an expanded CUG repeat-containing DMPK RNA for use in a method of treating an animal having type 1 myotonic dystrophy, wherein the oligonucleotide has a nucleobase sequence that is at least 90% complementary to SEQ ID NO: 1 and/or SEQ ID NO: 2 as measured over the entirety of said oligonucleotide, wherein the modified antisense oligonucleotide, when bound to the expanded CUG repeat-containing DMPK RNA, activates a nuclear ribonuclease.
A fluid coupling device comprising: a male connector component comprising a male coupling shuttle valve member disposed within the male connector component; and a locking sleeve coupled to the male connector component, wherein the locking sleeve is coupled to the male coupling shuttle valve member; a female connector component releasably matable to the male connector component; and a female coupling shuttle valve member partially disposed within the male connector component and partially disposed within the female connector component when the female connector component releasably mates with the male connector component, wherein sliding the locking sleeve longitudinally along the male connector component also longitudinally slides the male coupling shuttle valve member and the female coupling shuttle valve member within the fluid coupling device, wherein the sliding of the locking sleeve causes a blockage of fluid flow through the fluid coupling device. a male connector component comprising a male coupling shuttle valve member disposed within the male connector component; and a locking sleeve coupled to the male connector component, wherein the locking sleeve is coupled to the male coupling shuttle valve member; a male coupling shuttle valve member disposed within the male connector component; and a locking sleeve coupled to the male connector component, wherein the locking sleeve is coupled to the male coupling shuttle valve member; a female connector component releasably matable to the male connector component; and a female coupling shuttle valve member partially disposed within the male connector component and partially disposed within the female connector component when the female connector component releasably mates with the male connector component, wherein sliding the locking sleeve longitudinally along the male connector component also longitudinally slides the male coupling shuttle valve member and the female coupling shuttle valve member within the fluid coupling device, wherein the sliding of the locking sleeve causes a blockage of fluid flow through the fluid coupling device.
A control method for the operation of a combustion boiler, comprising: a) providing a predetermined upper limit (V F,max) for the flue gas velocity in at least one location of the boiler; b) monitoring the flue gas velocity (V F) during the combustion of fuel in said at least one location of the boiler; c) comparing the flue gas velocity(V F) with the predetermined upper limit (V F,max); characterized in that the method further comprises: d) decreasing the thermal load of the boiler if the flue gas velocity exceeds the predetermined upper limit (V F,max). a) providing a predetermined upper limit (V F,max) for the flue gas velocity in at least one location of the boiler; b) monitoring the flue gas velocity (V F) during the combustion of fuel in said at least one location of the boiler; c) comparing the flue gas velocity(V F) with the predetermined upper limit (V F,max); characterized in that the method further comprises: d) decreasing the thermal load of the boiler if the flue gas velocity exceeds the predetermined upper limit (V F,max).
Sensor arrangement (1, 1', 1", 5, 105) having at least one sensor module (34, 134) arranged on a carrier plate (32, 132) and a fastening arrangement with a metal bush (20, 20', 20", 120) and fastening means (40, 140), wherein the metal bush (20, 20', 20", 120) can be connected to a vehicle body (50, 150) via the fastening means (40, 140), wherein the metal bush (20, 20', 20", 120) comprises a sleeve (22, 22', 22", 122) as single-point fixing and a disc (24, 24', 24", 124) as carrier unit for the carrier plate (32, 132), and wherein the sleeve (22, 22', 22'', 122) is led through a central passage opening (33, 133) in the carrier plate (32, 132), and the sensor module (34, 134) is positioned on an area of the carrier plate (32, 132) which is not susceptible to interference and in which interfering influences of the carrier plate resonances and of resonances of further components (36, 11, 111) connected to the carrier plate (32, 132) are reduced.
An electronic device comprising: a memory configured to store a plurality of pieces of speech information used for voice recognition, wherein the plurality of pieces of speech information correspond to voice signals; and a processor including processing circuitry, the processor functionally connected to the memory, wherein the processor is configured to select speaker speech information from at least portions of the plurality of pieces of speech information based on mutual similarity, and to generate voice recognition information to be registered as personalized voice information based on the speaker speech information; wherein voice recognition information corresponds to voice commands; and wherein personalized voice information corresponds to phonemic models. a memory configured to store a plurality of pieces of speech information used for voice recognition, wherein the plurality of pieces of speech information correspond to voice signals; and a processor including processing circuitry, the processor functionally connected to the memory, wherein the processor is configured to select speaker speech information from at least portions of the plurality of pieces of speech information based on mutual similarity, and to generate voice recognition information to be registered as personalized voice information based on the speaker speech information; wherein voice recognition information corresponds to voice commands; and wherein personalized voice information corresponds to phonemic models.
A signal processing system for a hearing implant system having an implanted electrode array with a plurality of stimulation contacts for delivering electrode stimulation signals to adjacent auditory neural tissue, the system comprising: a band pass filter bank (402, 502) configured for processing an audio input signal to generate a plurality of band pass signals each representing an associated band of audio frequencies in the audio input signal; and an implant signal processor (400, 500) configured for processing the band pass signals to generate the electrode stimulation signals, wherein the processing includes: i. monitoring a key feature characteristic of the audio input signal, ii. using an original coding strategy to generate the electrode stimulation signals when the key feature is less than or equal to an initial value, and iii. using a different new coding strategy to generate the electrode stimulation signals when the key feature is greater than or equal to a coding change value; characterized in that the implant signal processor (400, 500) is configured for automatically transitioning from the original coding strategy to the new coding strategy over a transition period of time during which the implant signal processor adaptively changes the original coding strategy to become the new coding strategy, wherein one of the coding strategies is an event-based coding strategy and the other coding strategy is an envelope-based coding strategy. a band pass filter bank (402, 502) configured for processing an audio input signal to generate a plurality of band pass signals each representing an associated band of audio frequencies in the audio input signal; and an implant signal processor (400, 500) configured for processing the band pass signals to generate the electrode stimulation signals, wherein the processing includes: i. monitoring a key feature characteristic of the audio input signal, ii. using an original coding strategy to generate the electrode stimulation signals when the key feature is less than or equal to an initial value, and iii. using a different new coding strategy to generate the electrode stimulation signals when the key feature is greater than or equal to a coding change value; i. monitoring a key feature characteristic of the audio input signal, ii. using an original coding strategy to generate the electrode stimulation signals when the key feature is less than or equal to an initial value, and iii. using a different new coding strategy to generate the electrode stimulation signals when the key feature is greater than or equal to a coding change value; characterized in that the implant signal processor (400, 500) is configured for automatically transitioning from the original coding strategy to the new coding strategy over a transition period of time during which the implant signal processor adaptively changes the original coding strategy to become the new coding strategy, wherein one of the coding strategies is an event-based coding strategy and the other coding strategy is an envelope-based coding strategy.
A heat pump device, comprising a refrigerant circuit with a compressor, a low pressure sensor and a high pressure sensor, and with an injection, which can be active or inactive, wherein the high pressure sensor and the low pressure sensor (120, 110) are arranged upstream and downstream of the compressor and detect the pressure (p_C, p_0) in the refrigerant circuit upstream and downstream of the compressor, and a controller with a heat quantity unit for evaluating the quantity of heat generated by the heat pump device based on the signals from the low pressure sensor and the high pressure sensor, wherein the quantity of heat is determined by Q pkt C = p_0 * a − b * p_C * 1 − E + p_0 * C + p_C * d + e * E, wherein p_C indicates a condensing pressure, p_0 indicates an evaporating pressure and E (E=1; E=0) indicates that the injection is active or inactive, wherein a, b, C, d, e represent factors which can be determined on a test stand, the evaporating pressure p_0 is determined by the low pressure sensor and the condensing pressure p_C is determined by the high pressure sensor. wherein the high pressure sensor and the low pressure sensor (120, 110) are arranged upstream and downstream of the compressor and detect the pressure (p_C, p_0) in the refrigerant circuit upstream and downstream of the compressor, and a controller with a heat quantity unit for evaluating the quantity of heat generated by the heat pump device based on the signals from the low pressure sensor and the high pressure sensor, wherein the quantity of heat is determined by Q pkt C = p_0 * a − b * p_C * 1 − E + p_0 * C + p_C * d + e * E, wherein p_C indicates a condensing pressure, p_0 indicates an evaporating pressure and E (E=1; E=0) indicates that the injection is active or inactive, wherein a, b, C, d, e represent factors which can be determined on a test stand, the evaporating pressure p_0 is determined by the low pressure sensor and the condensing pressure p_C is determined by the high pressure sensor.
A method of generating expected average speeds of travel across one or more segments of an electronic map, the electronic map being representative of a network in an area covered by the electronic map, each segment representing a navigable segment of the network, and wherein each segment of the electronic map has associated therewith: an average speed of travel across that segment; segment data comprising at least one jam probability, the jam probability indicating the likelihood of a jam on that segment; and a jam speed indicative of the speed of travel on that segment when it is considered jammed, the method comprising: using a jam probability of the segment data to predict whether a jam condition exists on at least one or each of the segments; and outputting the expected average speed of travel across these segments as: a) a first speed when a jam condition is predicted to exist, the first speed being the jam speed for the relevant segment or a speed based thereon, or b) a second speed when a jam condition is not predicted, the second speed being the average speed for the relevant segment or a speed based thereon. an average speed of travel across that segment; segment data comprising at least one jam probability, the jam probability indicating the likelihood of a jam on that segment; and a jam speed indicative of the speed of travel on that segment when it is considered jammed, using a jam probability of the segment data to predict whether a jam condition exists on at least one or each of the segments; and outputting the expected average speed of travel across these segments as: a) a first speed when a jam condition is predicted to exist, the first speed being the jam speed for the relevant segment or a speed based thereon, or b) a second speed when a jam condition is not predicted, the second speed being the average speed for the relevant segment or a speed based thereon. a) a first speed when a jam condition is predicted to exist, the first speed being the jam speed for the relevant segment or a speed based thereon, or b) a second speed when a jam condition is not predicted, the second speed being the average speed for the relevant segment or a speed based thereon.
A method for determining density of fresh concrete inside a drum of a mixer truck using a probe, the drum having a rotation axis being at least partially horizontally-oriented, the probe being mounted inside the drum, extending in a radial orientation of the drum and being moved circumferentially as the drum rotates, and onto which a normal pressure is imparted by resistance due to the movement of the probe in the fresh concrete by the rotation of the drum and a normal pressure contribution is imparted by buoyancy due to a volume of the probe when the probe is submerged in the fresh concrete, the method comprising: receiving a first pressure value indicative of a normal pressure contribution exerted on the probe by the fresh concrete at a first circumferential position of the drum during rotation of the drum; receiving a second pressure value indicative of a normal pressure contribution exerted on the probe by the fresh concrete at a second circumferential position during rotation of the drum, the first circumferential position being different from the second circumferential position; and determining a density value of the fresh concrete based on the volume of the probe, the first pressure value and the second pressure value; wherein the first circumferential position lies on one side of the drum relative to the vertical and the second circumferential position lies on one other side of the drum relative to the vertical, wherein the step of determining includes using a trigonometric factor corresponding to a difference between the sinus of the first circumferential position and the sinus of the second circumferential position, and wherein none of the first and second circumferential positions of the drum corresponds to the bottom of the drum. receiving a first pressure value indicative of a normal pressure contribution exerted on the probe by the fresh concrete at a first circumferential position of the drum during rotation of the drum; receiving a second pressure value indicative of a normal pressure contribution exerted on the probe by the fresh concrete at a second circumferential position during rotation of the drum, the first circumferential position being different from the second circumferential position; and determining a density value of the fresh concrete based on the volume of the probe, the first pressure value and the second pressure value; wherein the first circumferential position lies on one side of the drum relative to the vertical and the second circumferential position lies on one other side of the drum relative to the vertical, wherein the step of determining includes using a trigonometric factor corresponding to a difference between the sinus of the first circumferential position and the sinus of the second circumferential position, and wherein none of the first and second circumferential positions of the drum corresponds to the bottom of the drum.
An integrated magnetic resonance device and a reactor comprising means for containing a flowing media and reacting said media; said reactor comprising a continuous wall portion, enveloping said reactor; said MRD comprising a permanent magnet (1 a), a pole piece (1 b), an array of side wall magnets (1 c), a shimming mechanism adapted to maintain uniform magnetic field within said reactor, a global gradient coil extending along the length of said reactor, an array of local gradient coils, positioned at intervals along the length of said reactor and overlapping each other such that any volume section within said reactor is within the field of at least one of the local gradient coils; said MRD is adapted for applying a magnetic field within said reactor for performing a plurality of localized spectroscopic measurements; characterized in that said permanent magnet (1 a), said pole piece (1 b), said array of side wall magnets (1 c), said shimming mechanism, said global gradient coil and said array of local gradient coils, are integrated within said continuous wall portion.
Appliance for heating water in a vessel, including an immersion part, which is immersible in the water to heat it, and a holder attachable to a wall of the vessel for attaching the appliance thereto, characterized in that the immersion part comprises a guide, which extends along a side of the immersion part and on which the holder is displaceably arranged to adjust the immersion depth.
A high pressure filter (100,200,300,400), comprising: a first housing (105,205,405) having a tapered surface (140,240) on a first end and a fluid fitting on a second end, at least a portion of the exterior surface of the first housing being threaded; a second housing (110,210,410) having a tapered surface (145,245) on a first end and a fluid fitting on a second end, the tapered surface of the second housing being tapered complementary to the tapered surface of the first housing; a filter element (125,225) centrally disposed within the first and second housings; a gasket (150,250,250',450) located between the tapered surfaces (140,145,240,245) of the first housing (105,205) and the second housing (110,210); and a compression collar (115,215,415) fitted over the second housing (110,210,410) and threaded onto the first housing (105,205,405). a second housing (110,210,410) having a tapered surface (145,245) on a first end and a fluid fitting on a second end, the tapered surface of the second housing being tapered complementary to the tapered surface of the first housing; a filter element (125,225) centrally disposed within the first and second housings; a gasket (150,250,250',450) located between the tapered surfaces (140,145,240,245) of the first housing (105,205) and the second housing (110,210); and a compression collar (115,215,415) fitted over the second housing (110,210,410) and threaded onto the first housing (105,205,405).
A travel state display device, comprising: A first travel position information recording unit configured to acquire and to record, first travel position information relating to a travel position of a first work vehicle that travels in a travel region by using a satellite positioning system; a second travel position information acquisition unit configured to acquire second travel position information relating to a travel position of a second work vehicle when the second work vehicle travels in the travel region by using the satellite positioning system, the second work vehicle being different from the first work vehicle; and a display control unit configured to cause a display unit to display the first travel position information and the second travel position information in a superimposed manner when the second work vehicle travels in the travel region, characterised in that the first travel position information includes a first wheel passing position when the first work vehicle travels in the travel region, the second travel position information includes a scheduled second wheel passing position estimated from a current position of the second work vehicle and obtained when the second work vehicle travels in the travel region, and the display control unit configured to cause the display unit to display the first wheel passing position of the first work vehicle and the scheduled second wheel passing position of the second work vehicle in a superimposed manner. A first travel position information recording unit configured to acquire and to record, first travel position information relating to a travel position of a first work vehicle that travels in a travel region by using a satellite positioning system; a second travel position information acquisition unit configured to acquire second travel position information relating to a travel position of a second work vehicle when the second work vehicle travels in the travel region by using the satellite positioning system, the second work vehicle being different from the first work vehicle; and a display control unit configured to cause a display unit to display the first travel position information and the second travel position information in a superimposed manner when the second work vehicle travels in the travel region, characterised in that the first travel position information includes a first wheel passing position when the first work vehicle travels in the travel region, the second travel position information includes a scheduled second wheel passing position estimated from a current position of the second work vehicle and obtained when the second work vehicle travels in the travel region, and the display control unit configured to cause the display unit to display the first wheel passing position of the first work vehicle and the scheduled second wheel passing position of the second work vehicle in a superimposed manner.