A method for adaptive adjustment of operating biases of photodetectors of an imaging system comprising a shutter, an array of photodetectors, and detector electronic circuitry for reading out image data from the array of photodetectors, the method comprising: acquiring, with the shutter closed to occlude the array of photodetectors, image data from the array of photodetectors during a first time period, the image data comprising an array of pixel values; adjusting operating bias points for individual pixels, wherein an adjusted operating bias point for an individual pixel is configured to adjust image data acquired with the shutter closed so that a pixel value from the individual pixel is within a threshold range around a data value assigned to a reference bias point; acquiring, with the shutter open to expose the array of photodetectors, image data of a scene at a time after the first time period, the image data acquired using the adjusted operating bias points; acquiring, with the shutter closed to occlude the array of photodetectors, image data from the array of photodetectors during a second time period after the first time period, the image data comprising an array of pixel values; re-adjusting the operating bias points for one or more individual pixels whose pixel values have drifted outside the threshold range, and not re-adjusting the operating bias points for one or more individual pixels with pixel values not equal to the reference bias point but within the threshold range, wherein a re-adjusted operating bias point for an individual pixel is configured to adjust image data acquired with the shutter closed so that a pixel value from the individual pixel is within the threshold range around the data value assigned to the reference bias point, wherein adjusting and re-adjusting an operating bias point comprises adjusting at least one component in a resistor digital-to-analog converter ("RDAC") network such that a finest adjustment level corresponds to a change of one least significant bit in the RDAC network, and wherein the threshold range is configured to exceed the size of the change in the operating bias point corresponding to a change of one least significant bit in the RDAC; and acquiring, with the shutter open to expose the array of photodetectors, image data of a scene at a time after the second time period, the image data acquired using the re-adjusted operating bias points. acquiring, with the shutter closed to occlude the array of photodetectors, image data from the array of photodetectors during a first time period, the image data comprising an array of pixel values; adjusting operating bias points for individual pixels, wherein an adjusted operating bias point for an individual pixel is configured to adjust image data acquired with the shutter closed so that a pixel value from the individual pixel is within a threshold range around a data value assigned to a reference bias point; acquiring, with the shutter open to expose the array of photodetectors, image data of a scene at a time after the first time period, the image data acquired using the adjusted operating bias points; acquiring, with the shutter closed to occlude the array of photodetectors, image data from the array of photodetectors during a second time period after the first time period, the image data comprising an array of pixel values; re-adjusting the operating bias points for one or more individual pixels whose pixel values have drifted outside the threshold range, and not re-adjusting the operating bias points for one or more individual pixels with pixel values not equal to the reference bias point but within the threshold range, wherein a re-adjusted operating bias point for an individual pixel is configured to adjust image data acquired with the shutter closed so that a pixel value from the individual pixel is within the threshold range around the data value assigned to the reference bias point, wherein adjusting and re-adjusting an operating bias point comprises adjusting at least one component in a resistor digital-to-analog converter ("RDAC") network such that a finest adjustment level corresponds to a change of one least significant bit in the RDAC network, and wherein the threshold range is configured to exceed the size of the change in the operating bias point corresponding to a change of one least significant bit in the RDAC; and acquiring, with the shutter open to expose the array of photodetectors, image data of a scene at a time after the second time period, the image data acquired using the re-adjusted operating bias points.