mhurhangee/ep-ind-claims huggingface dataset:
A composition for in vivo delivery of a compound to a target cell, the composition comprising a non-liposomal particle and at least one prodrug, wherein (a) the outer surface of the particle is a membrane comprised of the at least one prodrug, and is further comprised of 100% to 60% phospholipid, wherein the outer surface of the particle is capable of fusing to the outer leaflet of the target cell membrane in vivo, such fusion resulting in transfer of the prodrug from the particle to the outer leaflet of the target cell, and (b) the prodrug comprises a compound of less than 3000 da linked to an acyl moiety of a phosphoglyceride, wherein the compound may be released from the phosphoglyceride backbone via enzyme cleavage. (a) the outer surface of the particle is a membrane comprised of the at least one prodrug, and is further comprised of 100% to 60% phospholipid, wherein the outer surface of the particle is capable of fusing to the outer leaflet of the target cell membrane in vivo, such fusion resulting in transfer of the prodrug from the particle to the outer leaflet of the target cell, and (b) the prodrug comprises a compound of less than 3000 da linked to an acyl moiety of a phosphoglyceride, wherein the compound may be released from the phosphoglyceride backbone via enzyme cleavage.
An apparatus for imaging tissue in three dimensions, comprising a shaft, an acoustic imaging element disposed within the shaft and configured to capture a two-dimensional image slice of a tissue to be imaged, the imaging element including an active face that emits energy along a beam path and towards the tissue to be imaged, wherein the beam path is oriented perpendicular to a longitudinal axis of the shaft, an energy deflector positioned within the beam path, and a drive assembly coupled to the energy deflector, characterised in that the drive assembly is operable to oscillate the energy deflector about the longitudinal axis of the shaft on a pivot or a hinge which is positioned running through the energy deflector or on a side of the energy deflector.
A reset circuit for compensating a reduction of a level at a first node of a circuit during a first stage without affecting levels at the first node during a second stage, comprising a reset unit, a reset control unit, and at least three input terminals (X1, X2, X3), characterized in that: the at least three input terminals (X1, X2, X3) comprise a first input terminal, a second input terminal, and a third input terminal, wherein the first input terminal is coupled to the first node; the reset unit is coupled to the first input terminal, the second input terminal, and a second node, and is configured to be turned on if the second node is at a first level, so as to electrically couple the second input terminal with the first input terminal; and the reset control unit is coupled to the first input terminal, the second input terminal, the third input terminal, and the second node, and is configured to electrically couple the second input terminal with the second node if the first input terminal is at the first level, and to electrically couple the second node with the third input terminal if the second input terminal is at a second level. the at least three input terminals (X1, X2, X3) comprise a first input terminal, a second input terminal, and a third input terminal, wherein the first input terminal is coupled to the first node; the reset unit is coupled to the first input terminal, the second input terminal, and a second node, and is configured to be turned on if the second node is at a first level, so as to electrically couple the second input terminal with the first input terminal; and the reset control unit is coupled to the first input terminal, the second input terminal, the third input terminal, and the second node, and is configured to electrically couple the second input terminal with the second node if the first input terminal is at the first level, and to electrically couple the second node with the third input terminal if the second input terminal is at a second level.
Folding apparatus for sheets, comprising at least a conditioning unit suitable to prepare the sheet to be folded, at least an extraction mean mobile along the axis of said conditioning unit in order to extract from the conditioning unit the sheet prepared by the conditioning unit, and at least a folding unit suitable to fold the sheet previously prepared by the conditioning unit and coordinated with said conditioning unit, said conditioning unit being associable in a temporarily stable manner with a sheet feeding unit, wherein said conditioning unit comprises a containing body and a housing guide associated with a limiting body, characterized in that said containing body has a conditioning seating that houses a winding shaft cantilevered.
Device for testing the function of a driver assistance system of a motor vehicle or for characterising such a motor vehicle on a testing ground, characterised by - four ropes, - for each rope an electrically controllable winding and unwinding device for winding or unwinding the assigned rope, - for each rope a support mast over which the assigned rope is guided or by which the assigned winding and unwinding device is supported, - a holding device to which the test body can be fastened and which connects the four ropes together, and - a control device for controlling the winding and unwinding devices, wherein the control device is configured to receive position signals with information on the respective current position of a motor vehicle on the testing ground and the position of the test body on the testing ground, to process these position signals and to generate control signals based on the position signals which cause the winding and unwinding devices to wind or unwind the ropes and thereby move the test body along arbitrary desired trajectories based on the position of the motor vehicle. - four ropes, - for each rope an electrically controllable winding and unwinding device for winding or unwinding the assigned rope, - for each rope a support mast over which the assigned rope is guided or by which the assigned winding and unwinding device is supported, - a holding device to which the test body can be fastened and which connects the four ropes together, and - a control device for controlling the winding and unwinding devices, wherein the control device is configured to receive position signals with information on the respective current position of a motor vehicle on the testing ground and the position of the test body on the testing ground, to process these position signals and to generate control signals based on the position signals which cause the winding and unwinding devices to wind or unwind the ropes and thereby move the test body along arbitrary desired trajectories based on the position of the motor vehicle.
A method of suppressing an engine overspeed condition of an engine having at least one combustion chamber defined by a cylinder, a piston operable to reciprocate within the cylinder, and at least one intake valve and at least one exhaust valve associated with the cylinder, the engine having an engine cycle comprising an intake stroke, a compression stroke, an expansion stroke, and an exhaust stroke, wherein the intake valve is open during the intake stroke and closed during the compression stroke, the method comprising: determining whether the engine is operating in an engine overspeed condition; operating an engine overspeed suppression mechanism when the engine is operating in the engine overspeed condition, wherein operating the engine overspeed suppression mechanism comprises: causing the exhaust valve to be closed during a first stage of the compression stroke, and thereafter causing the exhaust valve to open during a second stage of the compression stroke. determining whether the engine is operating in an engine overspeed condition; operating an engine overspeed suppression mechanism when the engine is operating in the engine overspeed condition, wherein operating the engine overspeed suppression mechanism comprises: causing the exhaust valve to be closed during a first stage of the compression stroke, and thereafter causing the exhaust valve to open during a second stage of the compression stroke.
A wireless communication method, comprising: receiving, by a communication device from a serving cell, a signaling including a minimum threshold indication in a first slot n, wherein the minimum threshold indication indicates a first minimum threshold of k0, k0min, and a second minimum threshold of k2, k2min, wherein k0 includes an offset between a downlink control information, DCI, and a physical downlink shared channel, PDSCH, scheduled by the DCI, wherein k2 includes an offset between another DCI and a physical uplink shared channel, PUSCH, scheduled by the another DCI; and applying, by the communication device and for a cross-carrier scheduling, the first minimum threshold of k0, k0min, and the second minimum threshold of k2, k2min, in a second slot n+X, wherein X is a value that indicates an application delay, and wherein a subcarrier spacing, SCS, of the application delay is based on another SCS of the serving cell in a prior bandwidth part, BWP, before a BWP switching during the application delay. receiving, by a communication device from a serving cell, a signaling including a minimum threshold indication in a first slot n, wherein the minimum threshold indication indicates a first minimum threshold of k0, k0min, and a second minimum threshold of k2, k2min, wherein k0 includes an offset between a downlink control information, DCI, and a physical downlink shared channel, PDSCH, scheduled by the DCI, wherein k2 includes an offset between another DCI and a physical uplink shared channel, PUSCH, scheduled by the another DCI; and wherein the minimum threshold indication indicates a first minimum threshold of k0, k0min, and a second minimum threshold of k2, k2min, wherein k0 includes an offset between a downlink control information, DCI, and a physical downlink shared channel, PDSCH, scheduled by the DCI, wherein k2 includes an offset between another DCI and a physical uplink shared channel, PUSCH, scheduled by the another DCI; and applying, by the communication device and for a cross-carrier scheduling, the first minimum threshold of k0, k0min, and the second minimum threshold of k2, k2min, in a second slot n+X, wherein X is a value that indicates an application delay, and wherein a subcarrier spacing, SCS, of the application delay is based on another SCS of the serving cell in a prior bandwidth part, BWP, before a BWP switching during the application delay. wherein X is a value that indicates an application delay, and wherein a subcarrier spacing, SCS, of the application delay is based on another SCS of the serving cell in a prior bandwidth part, BWP, before a BWP switching during the application delay.
A medical system comprising: a control member including a body and a handle rotatable relative to the body about a first axis and a second axis different than the first axis; a plurality of control wires including a first control wire (326a, 326b), a second control wire, and a third control wire; a first disk coupled to the second control wire, and a second disk coupled to the third control wire; and a catheter; wherein rotating the handle about the first axis tensions the first control wire (326a, 326b) to deflect a distal portion of the catheter along a first plane; and wherein rotating the handle about the second axis in a first direction tensions the second control wire without pushing the third control wire to deflect the distal portion of the catheter in one direction along a second plane, and rotating the handle about the second axis in a second direction tensions the third control wire without pushing the second control wire to deflect the distal portion of the catheter in another direction along the second plane. a control member including a body and a handle rotatable relative to the body about a first axis and a second axis different than the first axis; a plurality of control wires including a first control wire (326a, 326b), a second control wire, and a third control wire; a first disk coupled to the second control wire, and a second disk coupled to the third control wire; and a catheter; wherein rotating the handle about the first axis tensions the first control wire (326a, 326b) to deflect a distal portion of the catheter along a first plane; and wherein rotating the handle about the second axis in a first direction tensions the second control wire without pushing the third control wire to deflect the distal portion of the catheter in one direction along a second plane, and rotating the handle about the second axis in a second direction tensions the third control wire without pushing the second control wire to deflect the distal portion of the catheter in another direction along the second plane.
Process for preparing polymers in the form of their aqueous polymer dispersions by means of free-radically initiated polymerization in a polymerization reactor equipped with an external cooling circuit having a pump and having at least one heat exchanger, characterized in that the heat exchanger installed is a shell and tube heat exchanger which is operated in such a way that the coolant is passed through the tubes of the tube aggregate and the polymerization mixture to be cooled is guided around the outside of the tubes of the tube aggregate.
At least one chemotherapeutic anti-cancer agent and at least one anti-GDF15 antibody or GDF15-binding fragment thereof for use in treating chemotherapy induced cachexia by increasing the overall survival in a subject having chemotherapy-induced cachexia.
A method comprising the steps of: a) accessing a Web page out of a plurality of Web pages of a Web site; b) determining a set of actions available to a user for the Web page; c) determining a set of the next pages linked to the Web page; d) defining a set of rules that modify the set of actions available to the user or the set of next pages linked to the Web page in accordance with an identity of the user; and e) storing the set of actions, the set of next pages, and the set of rules in a table data structure for the Web page to track a user flow of the Web page. a) accessing a Web page out of a plurality of Web pages of a Web site; b) determining a set of actions available to a user for the Web page; c) determining a set of the next pages linked to the Web page; d) defining a set of rules that modify the set of actions available to the user or the set of next pages linked to the Web page in accordance with an identity of the user; and e) storing the set of actions, the set of next pages, and the set of rules in a table data structure for the Web page to track a user flow of the Web page.
A chip, comprising: a selector, a one time programmable device, and a controller, wherein the controller is separately connected to a selection end of the selector and the one time programmable device, and the controller is configured to read a device value of the one time programmable device from the one time programmable device, wherein the device value of the one time programmable device is data stored at a preset storage address of the one time programmable device, and provide a first selection signal to the selection end of the selector when the device value of the one time programmable device is within a first preset range; a first input end of the selector is configured to receive access data, a second input end of the selector is configured to receive a preset invalid value, and an output end of the selector is connected to the one time programmable device; and the selector is configured to: when the first selection signal is input to the selection end, control the preset invalid value received by the second input end to be output from the output end of the selector to the one time programmable device, to prohibit subsequent access to the one time programmable device, wherein the controller is further configured to provide a second selection signal to the selection end of the selector when the device value of the one time programmable device is the same as a first preset value; the selector is configured to: when the second selection signal is input to the selection end, control the access data received by the first input end to be output from the output end of the selector to the one time programmable device; and the one time programmable device is configured to: when receiving the access data, burn program code compiled by a user to the one time programmable device according to the access data, wherein the first preset value is not within the first preset range.
Dustpan and broom assembly comprising a dustpan, and a broom comprising a broom handle and a brush having a brush back carrying bristles, the assembly having a broom element (A2, 1) wherein the brush is secured with the bristles of the broom extending beyond an edge of the broom element, and a dustpan element designed to scoop up waste, the dustpan element and the broom element comprising complementary assembly means (A2, D5; 12, 27; 13, 29) which are complementary to one another and designed such that, in an assembled position, the dustpan element and the broom element form a box containing the brush, characterized in that said broom handle comprises a plurality of separable pieces, the dustpan and broom assembly having a handle compartment (F2; 7) integrated in the box and designed to receive the pieces of the broom handle.
A network management system for managing a plurality of virtual network slices in a physical network, wherein the network management system comprises a single physical network datastore configured to store network configuration information for all network entities in the physical network, wherein the network configuration information is in a form of an encoded document and wherein the network management system comprises means for: generating a virtual network slice view of the physical network datastore for a first of the plurality of virtual network slices by filtering the network configuration information to obtain filtered network configuration information by applying at least one transformation to the encoded document to generate a transformed encoded document including the filtered network configuration information, the filtered network configuration information including network configuration information for only network entities assigned to the first of the plurality of virtual network slices; the network management system comprising means for performing said filtering of the network configuration information, and further comprising means for providing the filtered network configuration information to a first slice owner of the first of the plurality of virtual network slices.
An operation system for installation in a vehicle, the operation system comprising: a memory; and a processor coupled to the memory and configured to acquire a first signal indicating whether a seat in the vehicle is facing forward or rearward, and generate a display screen by arranging at least two operation elements (810, 820, 821, 822) or guide elements (1011, 1012) in a longitudinal direction of the vehicle, the display screen being displayed on a side operation panel installed on an inner side of a door of the vehicle, wherein the processor is configured to reverse the arrangement of the at least two operation elements (810, 820, 821, 822) or guide elements (1011, 1012) in the longitudinal direction of the vehicle in accordance with the first signal. a memory; and a processor coupled to the memory and configured to acquire a first signal indicating whether a seat in the vehicle is facing forward or rearward, and generate a display screen by arranging at least two operation elements (810, 820, 821, 822) or guide elements (1011, 1012) in a longitudinal direction of the vehicle, the display screen being displayed on a side operation panel installed on an inner side of a door of the vehicle, wherein the processor is configured to reverse the arrangement of the at least two operation elements (810, 820, 821, 822) or guide elements (1011, 1012) in the longitudinal direction of the vehicle in accordance with the first signal.
Method for manufacturing pile carpet or pile carpet tiles, wherein a pile yarn is connected via a pile thread holder to at least a primary backing, characterized in that the pile thread holder comprises a plurality of pile thread guide channels in a matrix-like configuration which perforate the pile thread holder through two opposite sides, wherein the pile thread holder is provided between a pile thread gripping station on a first perforated side and a primary backing on a second perforated side, and the pile yarn is arranged via the gripping station from the first perforated side through a pile thread guide channel to the second perforated side through the primary backing.
An aperture plate body having a plurality of apertures that taper between a first surface and a second surface, the apertures having an exit angle (θ) that is in the range of from 30° to 60° characterised in that the plate is formed from a palladium nickel alloy comprising about 89% of palladium and about 11% nickel and having a generally fine randomly oriented substantially equiaxed grain microstructure throughout the thickness of the aperture plate.
A method, performed by a terminal (1d-01, 1e-01), for a random access in a wireless communication system, the method comprising: receiving, from a base station (ld-01, 1e-01), a message including bandwidth part, BWP, configuration information for at least one downlink, DL, BWP and at least one uplink, UL, BWP for each of at least one serving cell, wherein an identity of each of the at least one DL BWP and the at least one UL BWP is identified based on the BWP configuration information; identifying (1g-09) a random access occasion configured for an active UL BWP of a serving cell; in case that the serving cell is a special cell and an ID of an active DL BWP of the serving cell is not same as an ID of the active UL BWP of the serving cell, switching the active DL BWP of the serving cell (1g-11) to a DL BWP of the serving cell with an ID same as the ID of the active UL BWP of the serving cell, and performing a random access procedure on the switched DL BWP (1g-13) of the serving cell and the active UL BWP of the serving cell; and in case that the serving cell is a secondary cell, SCell, performing a random access procedure on an active DL BWP (1g-15) of the special cell and the active UL BWP of the serving cell, wherein the special cell is a primary cell, PCell, or a primary secondary cell group cell. receiving, from a base station (ld-01, 1e-01), a message including bandwidth part, BWP, configuration information for at least one downlink, DL, BWP and at least one uplink, UL, BWP for each of at least one serving cell, wherein an identity of each of the at least one DL BWP and the at least one UL BWP is identified based on the BWP configuration information; identifying (1g-09) a random access occasion configured for an active UL BWP of a serving cell; in case that the serving cell is a special cell and an ID of an active DL BWP of the serving cell is not same as an ID of the active UL BWP of the serving cell, switching the active DL BWP of the serving cell (1g-11) to a DL BWP of the serving cell with an ID same as the ID of the active UL BWP of the serving cell, and performing a random access procedure on the switched DL BWP (1g-13) of the serving cell and the active UL BWP of the serving cell; and switching the active DL BWP of the serving cell (1g-11) to a DL BWP of the serving cell with an ID same as the ID of the active UL BWP of the serving cell, and performing a random access procedure on the switched DL BWP (1g-13) of the serving cell and the active UL BWP of the serving cell; and in case that the serving cell is a secondary cell, SCell, performing a random access procedure on an active DL BWP (1g-15) of the special cell and the active UL BWP of the serving cell, wherein the special cell is a primary cell, PCell, or a primary secondary cell group cell.