A system for production of an organic compound from a sugar source by fermentation, comprising: a fermentation vessel for containing a fermentation broth; a solids separation means in fluid connection with the fermentation vessel to receive at least a portion of the fermentation broth, wherein said solids separation means is configured to separate suspended solids from the fermentation broth to produce a clarified broth, and wherein said solids separation means is configured to conduct a flow of the clarified broth out of the separation means; a membrane module configured to receive the flow of clarified broth, wherein said membrane module comprises a selectively permeable membrane configured to permit preferential passage of the organic compound relative to water, and wherein said membrane module comprises: a broth inlet port to receive the flow of clarified broth from the solids separation means in a first flow direction tangential to the membrane; a broth exit port to conduct a flow of solvent-extracted broth comprising residual extraction solvent from the membrane module; a solvent inlet port to receive a flow of an extraction solvent in a second flow direction tangential to the membrane; an outlet port configured to conduct the flow of extraction solvent containing the organic compound from the membrane module; a pressurizing means to maintain a positive pressure on the flow of clarified broth relative to the flow of extraction solvent in the membrane module; and a decanter configured to receive the flow of solvent-extracted broth from the membrane module and to separate an extraction solvent phase comprising a portion of said residual extraction solvent from an aqueous phase of the solvent-extracted broth. a fermentation vessel for containing a fermentation broth; a solids separation means in fluid connection with the fermentation vessel to receive at least a portion of the fermentation broth, wherein said solids separation means is configured to separate suspended solids from the fermentation broth to produce a clarified broth, and wherein said solids separation means is configured to conduct a flow of the clarified broth out of the separation means; a membrane module configured to receive the flow of clarified broth, wherein said membrane module comprises a selectively permeable membrane configured to permit preferential passage of the organic compound relative to water, and wherein said membrane module comprises: a broth inlet port to receive the flow of clarified broth from the solids separation means in a first flow direction tangential to the membrane; a broth exit port to conduct a flow of solvent-extracted broth comprising residual extraction solvent from the membrane module; a solvent inlet port to receive a flow of an extraction solvent in a second flow direction tangential to the membrane; an outlet port configured to conduct the flow of extraction solvent containing the organic compound from the membrane module; a pressurizing means to maintain a positive pressure on the flow of clarified broth relative to the flow of extraction solvent in the membrane module; and a decanter configured to receive the flow of solvent-extracted broth from the membrane module and to separate an extraction solvent phase comprising a portion of said residual extraction solvent from an aqueous phase of the solvent-extracted broth. a broth inlet port to receive the flow of clarified broth from the solids separation means in a first flow direction tangential to the membrane; a broth exit port to conduct a flow of solvent-extracted broth comprising residual extraction solvent from the membrane module; a solvent inlet port to receive a flow of an extraction solvent in a second flow direction tangential to the membrane; an outlet port configured to conduct the flow of extraction solvent containing the organic compound from the membrane module; a pressurizing means to maintain a positive pressure on the flow of clarified broth relative to the flow of extraction solvent in the membrane module; and a decanter configured to receive the flow of solvent-extracted broth from the membrane module and to separate an extraction solvent phase comprising a portion of said residual extraction solvent from an aqueous phase of the solvent-extracted broth.