Selective operation valve, intended for equipping a recipient for biopharmaceutical use having a wall comprising an opening for this purpose, of the type having a main axis and comprising: • a hollow female part, having a lateral flange part adapted for attachment to the wall of the recipient and a first valve opening, • a hollow male part, mounted to slide axially within the female part in a stroke C between a closed state and an open state, having a proximal closing/opening part provided with a second valve opening, proximal, capable of selectively preventing or allowing the passage of fluid product when respectively in the closed state and in the open state, a distal portion provided with a distal opening, and a passageway adapted for the passage of fluid product, arranged in the proximal portion and the distal portion between the second valve opening and the distal opening, • sealing means, • the female part comprising a closed, transverse, proximal end wall, and a tubular wall extending axially and integral with the flange part, said tubular wall having a proximal section between the end wall and the flange part, extending axially for a length at least equal to the stroke C, and a distal section closed on the side opposite the proximal section relative to the flange part, the first opening being a lateral valve opening arranged in said proximal section, • the male part comprising a tubular wall extending axially, forming, on the proximal side, the closing/opening part whose open proximal transverse end constitutes the second opening, and forming, on the distal side, the distal portion, • the closing/opening part having an external shape and an external dimension that fit the internal shape and internal dimension of the proximal receiving part of the female part delimited by its end wall and its proximal section of tubular wall, characterized in that: • the sealing means comprise three ring seals spaced apart from each other in the axial direction, supported by the outer surface of the tubular wall of the male part and cooperating with the female part, a proximal seal to the fluid product, associated with the closing/opening part, a distal seal to contaminants of external original, the furthest from the proximal seal, and an intermediate seal to the fluid product and to contaminants of external origin, between the proximal seal and the distal seal. • a hollow female part, having a lateral flange part adapted for attachment to the wall of the recipient and a first valve opening, • a hollow male part, mounted to slide axially within the female part in a stroke C between a closed state and an open state, having a proximal closing/opening part provided with a second valve opening, proximal, capable of selectively preventing or allowing the passage of fluid product when respectively in the closed state and in the open state, a distal portion provided with a distal opening, and a passageway adapted for the passage of fluid product, arranged in the proximal portion and the distal portion between the second valve opening and the distal opening, • sealing means, • the female part comprising a closed, transverse, proximal end wall, and a tubular wall extending axially and integral with the flange part, said tubular wall having a proximal section between the end wall and the flange part, extending axially for a length at least equal to the stroke C, and a distal section closed on the side opposite the proximal section relative to the flange part, the first opening being a lateral valve opening arranged in said proximal section, • the male part comprising a tubular wall extending axially, forming, on the proximal side, the closing/opening part whose open proximal transverse end constitutes the second opening, and forming, on the distal side, the distal portion, • the closing/opening part having an external shape and an external dimension that fit the internal shape and internal dimension of the proximal receiving part of the female part delimited by its end wall and its proximal section of tubular wall, characterized in that: • the sealing means comprise three ring seals spaced apart from each other in the axial direction, supported by the outer surface of the tubular wall of the male part and cooperating with the female part, a proximal seal to the fluid product, associated with the closing/opening part, a distal seal to contaminants of external original, the furthest from the proximal seal, and an intermediate seal to the fluid product and to contaminants of external origin, between the proximal seal and the distal seal.