A method for checking the integrity of a biopharmaceutical fluid-containing pouch, using a device comprising at least one pressure sensor (6; 16), a control unit, two plates (1, 2) having porous front surfaces (SF1, SF2) between which is interposed the pouch to be checked and at least one actuator configured to move at least one of the plates, each plate having a frame (10, 20), an electrically conductive porous front layer (11, 21) and a porous intermediate layer (12, 22) interposed between the porous front layer and the frame, the intermediate layer being electrically non-conductive when dry, the method comprising: s1- applying a predetermined test pressure (Ptest) by bringing the two plates closer together by means of said actuator, thus sandwiching the pouch to be checked, s2- then maintaining the position of the plates during the rest of the test, s3- measuring a pressure value representative of the pressure prevailing in the pouch using the pressure sensor (6;16) and determining the characteristics of a pressure drop over time, s4- deducing therefrom, by the control unit, a defective state of the pouch if the pressure drop exceeds a predefined criterion, the method comprising, after step s1, and optionally, in parallel, steps s3 and s4: c- applying an electric potential difference between a frame electrode (10, 20; 17; 27) and the porous front layer (11, 21), d- measuring an electrical value representative of an electrical current (i-leak) passing through the intermediate layer (12, 22), such a current being representative of the presence of a leakage liquid inside the intermediate layer, e- deducing therefrom a defective state of the pouch if the electrical value representative of an electrical current exceeds a predefined criterion (Ith). s1- applying a predetermined test pressure (Ptest) by bringing the two plates closer together by means of said actuator, thus sandwiching the pouch to be checked, s2- then maintaining the position of the plates during the rest of the test, s3- measuring a pressure value representative of the pressure prevailing in the pouch using the pressure sensor (6;16) and determining the characteristics of a pressure drop over time, s4- deducing therefrom, by the control unit, a defective state of the pouch if the pressure drop exceeds a predefined criterion, the method comprising, after step s1, and optionally, in parallel, steps s3 and s4: c- applying an electric potential difference between a frame electrode (10, 20; 17; 27) and the porous front layer (11, 21), d- measuring an electrical value representative of an electrical current (i-leak) passing through the intermediate layer (12, 22), such a current being representative of the presence of a leakage liquid inside the intermediate layer, e- deducing therefrom a defective state of the pouch if the electrical value representative of an electrical current exceeds a predefined criterion (Ith). c- applying an electric potential difference between a frame electrode (10, 20; 17; 27) and the porous front layer (11, 21), d- measuring an electrical value representative of an electrical current (i-leak) passing through the intermediate layer (12, 22), such a current being representative of the presence of a leakage liquid inside the intermediate layer, e- deducing therefrom a defective state of the pouch if the electrical value representative of an electrical current exceeds a predefined criterion (Ith).