A computer-implemented method for assessing swallowing motor function in a subject, the method including: (a) accessing from a database or from a server intraluminal impedance measurements and pressure measurements that have previously been obtained from the pharynx and/or esophagus of the subject during clearance of a bolus from the mouth and/or throat of the subject, wherein the intraluminal impedance measurements are used to generate an impedance waveform of bolus clearance and the pressure measurements are used to generate a pressure waveform of the bolus clearance; (b) deriving values for pressure-flow variables in the pharynx and/or esophagus of the subject, wherein said pressure-flow variables include: (i) duration of the drop in intraluminal impedance during bolus clearance (Flow Interval); (ii) pressure at the nadir of the impedance waveform (PNadlmp); (iii) peak pressure of the pressure waveform (PeakP); (iv) time from the nadir of the impedance waveform to the peak pressure (TNadlmp-PeakP); wherein the values of said pressure-flow variables are combined to generate a swallow risk index in the subject, wherein said swallow risk index has the following formula: Flow Interval × PNadlmp PeakP × TNadlmp − PeakP + 1 x 100. and (c) assessing swallowing motor function in the subject, wherein a swallow risk index which is higher than a predetermined reference swallow index is indicative of an ineffective swallow and/or a risk of aspiration in the subject. (a) accessing from a database or from a server intraluminal impedance measurements and pressure measurements that have previously been obtained from the pharynx and/or esophagus of the subject during clearance of a bolus from the mouth and/or throat of the subject, wherein the intraluminal impedance measurements are used to generate an impedance waveform of bolus clearance and the pressure measurements are used to generate a pressure waveform of the bolus clearance; (b) deriving values for pressure-flow variables in the pharynx and/or esophagus of the subject, wherein said pressure-flow variables include: (i) duration of the drop in intraluminal impedance during bolus clearance (Flow Interval); (ii) pressure at the nadir of the impedance waveform (PNadlmp); (iii) peak pressure of the pressure waveform (PeakP); (iv) time from the nadir of the impedance waveform to the peak pressure (TNadlmp-PeakP); wherein the values of said pressure-flow variables are combined to generate a swallow risk index in the subject, wherein said swallow risk index has the following formula: Flow Interval × PNadlmp PeakP × TNadlmp − PeakP + 1 x 100. and (i) duration of the drop in intraluminal impedance during bolus clearance (Flow Interval); (ii) pressure at the nadir of the impedance waveform (PNadlmp); (iii) peak pressure of the pressure waveform (PeakP); (iv) time from the nadir of the impedance waveform to the peak pressure (TNadlmp-PeakP); wherein the values of said pressure-flow variables are combined to generate a swallow risk index in the subject, wherein said swallow risk index has the following formula: Flow Interval × PNadlmp PeakP × TNadlmp − PeakP + 1 x 100. and (c) assessing swallowing motor function in the subject, wherein a swallow risk index which is higher than a predetermined reference swallow index is indicative of an ineffective swallow and/or a risk of aspiration in the subject.