An implantable neurostimulation system, comprising: a first VNS electrode assembly configured to couple to and deliver electrical stimulation to a vagus nerve (15, 16); a first CBS electrode configured to couple to and deliver electrical stimulation to carotid baroreceptors; and a pulse generator comprising: a vagus nerve stimulation subsystem comprising VNS stimulation circuitry; an implantable carotid baroreceptor stimulation subsystem comprising CBS stimulation circuitry; and a control system; and characterised in that said control system is configured to: activate the VNS subsystem and control the VNS stimulation circuitry to deliver electrical energy to the first VNS electrode assembly according to a first set of parameters; activate the CBS subsystem and control the CBS stimulation circuitry to deliver electrical energy to the first CBS electrode assembly according to a second set of parameters different than the first set of parameters; estimate an activity level of the patient; and temporarily suspend CBS therapy during a period of increased activity level. a first VNS electrode assembly configured to couple to and deliver electrical stimulation to a vagus nerve (15, 16); a first CBS electrode configured to couple to and deliver electrical stimulation to carotid baroreceptors; and a pulse generator comprising: a vagus nerve stimulation subsystem comprising VNS stimulation circuitry; an implantable carotid baroreceptor stimulation subsystem comprising CBS stimulation circuitry; and a control system; and characterised in that said control system is configured to: activate the VNS subsystem and control the VNS stimulation circuitry to deliver electrical energy to the first VNS electrode assembly according to a first set of parameters; activate the CBS subsystem and control the CBS stimulation circuitry to deliver electrical energy to the first CBS electrode assembly according to a second set of parameters different than the first set of parameters; estimate an activity level of the patient; and temporarily suspend CBS therapy during a period of increased activity level. a vagus nerve stimulation subsystem comprising VNS stimulation circuitry; an implantable carotid baroreceptor stimulation subsystem comprising CBS stimulation circuitry; and a control system; and characterised in that said control system is configured to: activate the VNS subsystem and control the VNS stimulation circuitry to deliver electrical energy to the first VNS electrode assembly according to a first set of parameters; activate the CBS subsystem and control the CBS stimulation circuitry to deliver electrical energy to the first CBS electrode assembly according to a second set of parameters different than the first set of parameters; estimate an activity level of the patient; and temporarily suspend CBS therapy during a period of increased activity level. activate the VNS subsystem and control the VNS stimulation circuitry to deliver electrical energy to the first VNS electrode assembly according to a first set of parameters; activate the CBS subsystem and control the CBS stimulation circuitry to deliver electrical energy to the first CBS electrode assembly according to a second set of parameters different than the first set of parameters; estimate an activity level of the patient; and temporarily suspend CBS therapy during a period of increased activity level.