A delivery system for introducing an active agent coated balloon into a subject comprising: an introducing sheath; a tunneling sheath disposed within the introducing sheath, the tunneling sheath comprising: a tubular shaft having an outer diameter and defining a lumen, the shaft having a proximal end and a distal end; and a proximal collar defining a lumen, the proximal collar attached to the tubular shaft at the proximal end, the proximal collar comprising an outer diameter that is greater than the outer diameter of the tubular shaft; and a balloon catheter disposed within the tunneling sheath and the introducing sheath, the balloon catheter comprising: a balloon catheter shaft disposed within the tubular shaft, the balloon catheter shaft comprising a lumen for the passage of a fluid therein; an expandable balloon disposed on the balloon catheter shaft in fluid communication with the lumen of the balloon catheter shaft; and an active agent layer disposed on the expandable balloon; wherein the tunneling sheath and the balloon catheter are configured to be fixed with respect to one another such that the position of the expandable balloon is configured to be stationary relative to the tubular shaft as the delivery system is passed through a blood vessel of a patient, and the tunneling sheath and balloon catheter are moveable together through the introducing sheath; wherein a volume of the tubular shaft that is not taken up by the balloon catheter is filled with a biocompatible liquid. an introducing sheath; a tunneling sheath disposed within the introducing sheath, the tunneling sheath comprising: a tubular shaft having an outer diameter and defining a lumen, the shaft having a proximal end and a distal end; and a proximal collar defining a lumen, the proximal collar attached to the tubular shaft at the proximal end, the proximal collar comprising an outer diameter that is greater than the outer diameter of the tubular shaft; and a tubular shaft having an outer diameter and defining a lumen, the shaft having a proximal end and a distal end; and a proximal collar defining a lumen, the proximal collar attached to the tubular shaft at the proximal end, the proximal collar comprising an outer diameter that is greater than the outer diameter of the tubular shaft; and a balloon catheter disposed within the tunneling sheath and the introducing sheath, the balloon catheter comprising: a balloon catheter shaft disposed within the tubular shaft, the balloon catheter shaft comprising a lumen for the passage of a fluid therein; an expandable balloon disposed on the balloon catheter shaft in fluid communication with the lumen of the balloon catheter shaft; and an active agent layer disposed on the expandable balloon; wherein the tunneling sheath and the balloon catheter are configured to be fixed with respect to one another such that the position of the expandable balloon is configured to be stationary relative to the tubular shaft as the delivery system is passed through a blood vessel of a patient, and the tunneling sheath and balloon catheter are moveable together through the introducing sheath; a balloon catheter shaft disposed within the tubular shaft, the balloon catheter shaft comprising a lumen for the passage of a fluid therein; an expandable balloon disposed on the balloon catheter shaft in fluid communication with the lumen of the balloon catheter shaft; and an active agent layer disposed on the expandable balloon; wherein the tunneling sheath and the balloon catheter are configured to be fixed with respect to one another such that the position of the expandable balloon is configured to be stationary relative to the tubular shaft as the delivery system is passed through a blood vessel of a patient, and the tunneling sheath and balloon catheter are moveable together through the introducing sheath; wherein a volume of the tubular shaft that is not taken up by the balloon catheter is filled with a biocompatible liquid.