A fluid infusion device, comprising: a housing that includes a lock (406, 508) and defines an opening that receives a removable fluid reservoir, the lock spaced apart from the opening; and a set connector assembly (402, 502) for the fluid infusion device, the set connector assembly comprising: a connector (400, 500) having a body (420, 510), the body defining a graspable portion (422, 512) and a coupling portion (302, 514), the coupling portion to be received within the opening of the housing, and the graspable portion includes a hub (424, 516) coupled to the coupling portion and a locking arm (426, 518) having a first end coupled to the hub and a second end that has a locking tab (434, 524) to lock the connector to the fluid infusion device, the hub defines a bore that extends along a longitudinal axis of the connector, the locking arm movable relative to the coupling portion to move the connector between a first, locked position and a second, unlocked position relative to the fluid infusion device and the locking arm extends a distance (D3, D4) beyond a perimeter of the coupling portion to provide a force to bias the locking arm into the lock of the housing, wherein the bore is to receive a needle and a tube to define a fluid flow path out of the fluid infusion device; wherein the set connector assembly (402, 502) is removably couplable to the housing to define a fluid flow path from the removable fluid reservoir of the fluid infusion device, the coupling portion receivable within the opening of the housing and coupled to the removable fluid reservoir, and the locking tab engages the lock, with the locking arm movable relative to the coupling portion to move the connector between the first, locked position and the second, unlocked position relative to the housing. a housing that includes a lock (406, 508) and defines an opening that receives a removable fluid reservoir, the lock spaced apart from the opening; and a set connector assembly (402, 502) for the fluid infusion device, the set connector assembly comprising: a connector (400, 500) having a body (420, 510), the body defining a graspable portion (422, 512) and a coupling portion (302, 514), the coupling portion to be received within the opening of the housing, and the graspable portion includes a hub (424, 516) coupled to the coupling portion and a locking arm (426, 518) having a first end coupled to the hub and a second end that has a locking tab (434, 524) to lock the connector to the fluid infusion device, the hub defines a bore that extends along a longitudinal axis of the connector, the locking arm movable relative to the coupling portion to move the connector between a first, locked position and a second, unlocked position relative to the fluid infusion device and the locking arm extends a distance (D3, D4) beyond a perimeter of the coupling portion to provide a force to bias the locking arm into the lock of the housing, wherein the bore is to receive a needle and a tube to define a fluid flow path out of the fluid infusion device; wherein the set connector assembly (402, 502) is removably couplable to the housing to define a fluid flow path from the removable fluid reservoir of the fluid infusion device, the coupling portion receivable within the opening of the housing and coupled to the removable fluid reservoir, and the locking tab engages the lock, with the locking arm movable relative to the coupling portion to move the connector between the first, locked position and the second, unlocked position relative to the housing.