mhurhangee/ep-ind-claims huggingface dataset:
A therapeutic agent for an ophthalmic disease comprising a vascular endothelial growth factor (VEGF) receptor inhibitor in a nanoparticle form, wherein the VEGF receptor inhibitor is a compound represented by formula: or a pharmaceutically acceptable salt thereof, or a hydrate or a solvate of the compound or the salt, wherein the therapeutic agent for the ophthalmic disease is in the form of eye drops.
A stable, synthetic capture agent that specifically binds IL-17F, wherein the capture agent comprises a first ligand having affinity for a first epitope on IL-17F, a second ligand having affinity for a second epitope on IL-17F, and a linker covalently connecting the first ligand to the second ligand, wherein the first epitope comprises the amino acid sequence FFQKPES, wherein the second epitope comprises the amino acid sequence NENQRVS, wherein the capture agent is selective for IL-17F over IL-17A, wherein the first ligand is cyclic, wherein the second ligand is cyclic, wherein the length of the linker is from ~8.8 Å to ~26.4 Å or from ~7 Å to ~15 Å, wherein the first ligand comprises an amino acid sequence selected from the group consisting of: a. FYKTH; b. FYKQH; c. FYLTH; d. FYLQH; e. RRATS; and f. RRAQS, and wherein the second ligand comprises an amino acid sequence selected from the group consisting of: a. KYGEV; b. LYGEV; c. VHKSG; d. VHLSG; e. QKHGP; f. TKHGP; g. QLHGP; h. TLHGP; i. YDLQR; j. YDLTR; k. YDKQR; l. YDKTR; m. KKGWP; n. KLGWP; o. LKGWP; p. LLGWP; q. RSYNL; and r. RSYNK. a. FYKTH; b. FYKQH; c. FYLTH; d. FYLQH; e. RRATS; and f. RRAQS, a. KYGEV; b. LYGEV; c. VHKSG; d. VHLSG; e. QKHGP; f. TKHGP; g. QLHGP; h. TLHGP; i. YDLQR; j. YDLTR; k. YDKQR; l. YDKTR; m. KKGWP; n. KLGWP; o. LKGWP; p. LLGWP; q. RSYNL; and r. RSYNK.
Vehicle, in particular a rail vehicle, with a drive having one or more electric motors (21, 22), a drive controller connected to the drive and controlling it, and a monitoring device having a braking capacity calculation module, wherein the braking capacity calculation module determines a braking capacity value of the motor or motors (21, 22) and is directly or indirectly connected to a brake controller of the vehicle, characterised in that - in addition to the drive controller, the monitoring device is present and works independently of the drive controller and - the braking capacity calculation module of the brake controller of the vehicle transmits the braking capacity value, determined independently of the drive controller, of the motor or motors (21, 22). - in addition to the drive controller, the monitoring device is present and works independently of the drive controller and - the braking capacity calculation module of the brake controller of the vehicle transmits the braking capacity value, determined independently of the drive controller, of the motor or motors (21, 22).
A method for the determination of the hyaluronic acid content of a hydrogel, the method comprising the following steps: a. preparing, as reagent A, a solution of sodium tetraborate in sulfuric acid; b. preparing reagent B by dissolving carbazole in ethanol; c. preparing test solutions by dissolving the hydrogel in an aqueous solution; d. treating the test solution with ultrasounds for a period of time sufficient to obtain a macroscopically homogeneous solution; e. preparing a reference stock solution by dissolving glucuronic acid, or a glucuronic acid-containing substance in an aqueous solution; f. preparing at least 3 reference solutions by dilution of the reference stock solution in aqueous solution, preferably at concentration comprised between 0.0005% w/v and 0.0100% w/v, preferably between 0.0010 % w/v and 0.0050 % w/v; g. preparing the test tubes by admixing reagent A, reagent B and one of the following: reference solution, test solution, aqueous solution (blank), and optionally solution for interference (crosslinker sample or additive sample); place each test tube on a water bath for at least 5 min, then cool them to room temperature; h. reading the absorbance at a wavelength comprised between 500 and 580 nm, preferably at about 530 nm, against the blank and optionally the sample for interference. a. preparing, as reagent A, a solution of sodium tetraborate in sulfuric acid; b. preparing reagent B by dissolving carbazole in ethanol; c. preparing test solutions by dissolving the hydrogel in an aqueous solution; d. treating the test solution with ultrasounds for a period of time sufficient to obtain a macroscopically homogeneous solution; e. preparing a reference stock solution by dissolving glucuronic acid, or a glucuronic acid-containing substance in an aqueous solution; f. preparing at least 3 reference solutions by dilution of the reference stock solution in aqueous solution, preferably at concentration comprised between 0.0005% w/v and 0.0100% w/v, preferably between 0.0010 % w/v and 0.0050 % w/v; g. preparing the test tubes by admixing reagent A, reagent B and one of the following: reference solution, test solution, aqueous solution (blank), and optionally solution for interference (crosslinker sample or additive sample); place each test tube on a water bath for at least 5 min, then cool them to room temperature; h. reading the absorbance at a wavelength comprised between 500 and 580 nm, preferably at about 530 nm, against the blank and optionally the sample for interference.
An injector for injecting moldable liquid comprising: a barrel; a feed screw concentrically located in the barrel; and a motor having a drive shaft removably coupled to the feed screw via a bayonet connector;injector characterized in that the bayonet connector includes a receiver, and an insert including a first end, and a second end distal from the first end, the first end removably coupled to and housed in the receiver, the second end coupled to the feed screw, the drive shaft including a hollow portion having a non-round cross-section, the receiver shaped for a snug fit and housed in the hollow portion such that rotating the drive shaft about an axis of the drive shaft rotates the receiver. a barrel; a feed screw concentrically located in the barrel; and a motor having a drive shaft removably coupled to the feed screw via a bayonet connector;injector characterized in that the bayonet connector includes a receiver, and an insert including a first end, and a second end distal from the first end, the first end removably coupled to and housed in the receiver, the second end coupled to the feed screw, the drive shaft including a hollow portion having a non-round cross-section, the receiver shaped for a snug fit and housed in the hollow portion such that rotating the drive shaft about an axis of the drive shaft rotates the receiver.
A tube filling apparatus for filling tubes (100, 102, 104) with a herb mixture, the apparatus including: a base; a filling assembly mountable on the base, the filling assembly having a number of tube receiving recesses (26.1, 26.2) wherein tubes may be received; a vibration plate being locatable between the base and the filling assembly such that, in use, the tubes rest on the vibration plate when they are located in the recesses; and vibrating means which is in connection with the vibration plate for, in use, vibrating the vibration plate; wherein the vibration plate is capable of moving independently from the filling assembly. a base; a filling assembly mountable on the base, the filling assembly having a number of tube receiving recesses (26.1, 26.2) wherein tubes may be received; a vibration plate being locatable between the base and the filling assembly such that, in use, the tubes rest on the vibration plate when they are located in the recesses; and vibrating means which is in connection with the vibration plate for, in use, vibrating the vibration plate; wherein the vibration plate is capable of moving independently from the filling assembly.
An antimicrobial set screw for an antimicrobial implant device comprising a set screw body having a screw portion and a head portion wherein the screw portion has a screw groove on the outer surface thereof and the head portion has an opening on the top thereof; and a cap having a leg portion for fitting the opening of the set screw body, wherein at least a surface of the opening of the set screw body and at least a surface of the leg portion of the cap comprise a first material and a second material that have a potential difference; the first material comprises an antimicrobial metal; the second material is nobler than the first material; an electric circuit is formed between the first material and the second material when the set screw is implanted in vivo for use; ions of the antimicrobial metal are eluted from the first material under a presence of an electrolyte to impart an antimicrobial property to a surface and/or a surrounding area of the first material; wherein the first material is a cobalt-based alloy; wherein the second material is titanium or a titanium-based alloy; and wherein a ratio of a surface area of the second material to a surface area of the first material (second material/first material) is in a range of 0.2 to 10.8.
A toner comprising toner particles which comprise toner base particles having at least a colorant and a binder resin, and an inorganic fine powder added externally to the toner base particles, wherein; said inorganic fine powder has a primary-particle average particle diameter of from 30 nm to 300 nm, and has particles having at least one of a cubic particle shape, a cube-like particle shape, a rectangular particle shape and a rectangle-like particle shape and having perovskite type crystals; said inorganic fine powder has particles and agglomerates both having particle diameters of 600 nm or more, in a content of 0% to 1% by number; and said inorganic fine powder is in a liberation percentage, as determined in accordance with description, of 20% by volume or less with respect to the toner base particles.
An article sorting apparatus, comprising: a conveyance path extending in a first conveyance direction, the conveyance path having a curve (21, 22, 23, 24); a conveyance unit configured to move along the conveyance path and to convey an article loaded on the conveyance unit in a second conveyance direction that intersects the first conveyance direction of the conveyance path; a loading portion configured to load the article onto the conveyance unit; a sorting portion (15, 16) configured to sort the article conveyed by the conveyance unit; and a controller configured to control movement of the conveyance unit in the first conveyance direction and conveyance of the article in the second conveyance direction characterized in that the controller is configured to control the conveyance unit before entry of the conveyance unit into the curve (21, 22, 23, 24) such that if the curve (21, 22, 23, 24) has a curvature radius that is less than a predetermined threshold value, the position of the article on a load surface of the conveyance unit on which the article is placed is adjusted to a position that is offset from a middle position on the load surface to an inward side with respect to a radial direction of the curve (21, 22, 23, 24). a conveyance path extending in a first conveyance direction, the conveyance path having a curve (21, 22, 23, 24); a conveyance unit configured to move along the conveyance path and to convey an article loaded on the conveyance unit in a second conveyance direction that intersects the first conveyance direction of the conveyance path; a loading portion configured to load the article onto the conveyance unit; a sorting portion (15, 16) configured to sort the article conveyed by the conveyance unit; and a controller configured to control movement of the conveyance unit in the first conveyance direction and conveyance of the article in the second conveyance direction
An air separation unit for an OBOGS comprising a housing having an inlet for receiving a wet inlet air and an outlet for outputting a dry product gas, the housing including an outer side wall and first, second and third annular walls (21, 23, 25) to thereby define a series of concentric annular chambers (20,22,24) within the housing, wherein: a. a first annular chamber is defined by the outer side wall and a first annular wall and is fluidly coupled to the inlet, the first annular chamber including a desiccant material configured to receive the wet inlet air and output a dried air; b. an unfilled second annular chamber defined by the first annular wall and a second annular wall and fluidly coupled to the first annular chamber via a first passageway; and c. a third annular chamber defined by the second annular wall and the third annular wall and fluidly coupled to the second annular chamber via a second passageway at a first end and the outlet at a second end, the third annular chamber configured to receive air separation material to selectively remove unwanted constituents from the dried air and output the dry product gas. a. a first annular chamber is defined by the outer side wall and a first annular wall and is fluidly coupled to the inlet, the first annular chamber including a desiccant material configured to receive the wet inlet air and output a dried air; b. an unfilled second annular chamber defined by the first annular wall and a second annular wall and fluidly coupled to the first annular chamber via a first passageway; and c. a third annular chamber defined by the second annular wall and the third annular wall and fluidly coupled to the second annular chamber via a second passageway at a first end and the outlet at a second end, the third annular chamber configured to receive air separation material to selectively remove unwanted constituents from the dried air and output the dry product gas.
A power tool connected to a battery pack including a battery, comprising: a drive part driven by electric power supplied from the battery; a first switch unit for setting arbitrarily power supply from the battery to the drive part in ON/OFF state; a second switch unit for setting the power supply to the drive part in ON/OFF state, characterised in that said second switch unit is adapted to set the power supply to the drive part in ON/OFF state on the basis of a detection signal in accordance with the connection state of the battery pack; first signal output means (411, 412) is adapted to output a first detection signal for permitting the power supply from the battery to the drive part, the first detection signal being input to the second switch unit; and second signal output means (421, 422) is adapted to out-put a second detection signal for interrupting the power supply from the battery to the drive part, the second detection signal being input to the second switch unit, wherein in case that the battery and the drive part are connected in a state where the first switch unit is turned on, the second detection signal for interrupting the power supply is input into the second switch unit. a drive part driven by electric power supplied from the battery; a first switch unit for setting arbitrarily power supply from the battery to the drive part in ON/OFF state; a second switch unit for setting the power supply to the drive part in ON/OFF state, characterised in that said second switch unit is adapted to set the power supply to the drive part in ON/OFF state on the basis of a detection signal in accordance with the connection state of the battery pack; first signal output means (411, 412) is adapted to output a first detection signal for permitting the power supply from the battery to the drive part, the first detection signal being input to the second switch unit; and second signal output means (421, 422) is adapted to out-put a second detection signal for interrupting the power supply from the battery to the drive part, the second detection signal being input to the second switch unit, wherein in case that the battery and the drive part are connected in a state where the first switch unit is turned on, the second detection signal for interrupting the power supply is input into the second switch unit.
A cochlear implant comprising: a processor; an array of electrodes disposed along a flexible body; and a lead body connecting the processor to the array of electrodes, the lead body comprising: a first tube having a first outside diameter; a second tube having a second outside diameter smaller than the first diameter, a portion of the second tube being disposed within the first tube; wires passing through the first tube and the second tube, the wires comprising a helically coiled portion; charactezed in that the lead body further comprises a third tube, an internal portion of the third tube molded into the flexible body and an external portion of the third tube extending out of the flexible body, in which the wires pass linearly through the third tube. a processor; an array of electrodes disposed along a flexible body; and a lead body connecting the processor to the array of electrodes, the lead body comprising: a first tube having a first outside diameter; a second tube having a second outside diameter smaller than the first diameter, a portion of the second tube being disposed within the first tube; wires passing through the first tube and the second tube, the wires comprising a helically coiled portion; a first tube having a first outside diameter; a second tube having a second outside diameter smaller than the first diameter, a portion of the second tube being disposed within the first tube; wires passing through the first tube and the second tube, the wires comprising a helically coiled portion; charactezed in that the lead body further comprises a third tube, an internal portion of the third tube molded into the flexible body and an external portion of the third tube extending out of the flexible body, in which the wires pass linearly through the third tube.
Device for attaching an exhaust gas collector to a wall of the cylinder head of a heat engine which exhibits a substantially vertical wall extended by an inclined wall, resting against which the collector is attached, said collector being extended by an end flange comprising a lower strip secured to the cylinder head and a diametrically opposite upper strip including a contact surface, said device comprising an attachment bar including a plate for attachment to the vertical wall of the cylinder head and a plate for pressing against the upper strip, having a shape which is complementary to the contact surface of the upper strip and including a deformable elastic part, characterized in that the lower strip surrounds an axis of an attachment screw embedded in the inclined wall of the cylinder head and exhibits a beveled profile.
A method for producing three-dimensional information of an object in medical X-ray imaging in which method the object is X-radiated from at least two different directions and the said X-radiation is detected to form projection data of the object, characterized in that, - said projection data is utilized in a regularized reconstruction method based on solving the non-linear evolution equation ∂ t ⁢ φ x t = - h x t ⁢ A * A f φ x t - m + α P φ x t to produce three-dimensional information of the object, x representing the coordinates inside the object under imaging, t representing time, φ representing a level set function indicating the boundary of the object, h representing a positive-valued function, m representing projection data, the operator A representing the X-radiation attenuation model, A* representing the backprojection operator, α representing a positive number, P representing high pass filtering, and f representing a cut-off function returning zero for non-positive arguments and positive values for positive arguments. - said projection data is utilized in a regularized reconstruction method based on solving the non-linear evolution equation ∂ t ⁢ φ x t = - h x t ⁢ A * A f φ x t - m + α P φ x t to produce three-dimensional information of the object, x representing the coordinates inside the object under imaging, t representing time, φ representing a level set function indicating the boundary of the object, h representing a positive-valued function, m representing projection data, the operator A representing the X-radiation attenuation model, A* representing the backprojection operator, α representing a positive number, P representing high pass filtering, and f representing a cut-off function returning zero for non-positive arguments and positive values for positive arguments.
Antiballistic panel comprising at least a first stack and a second stack, wherein the first stack has a plurality of first laminates made of a first kind of fibers and the second stack has a plurality of second laminates made of a second kind of fibers, wherein the first kind of fibers has a tensile modulus in the range of 40-85 GPa measured according to ASTM D7269 and the second kind of fibers have a tensile modulus in the range of 86-140 GPa measured according to ASTM D7269.
A method for producing a radioactive substance comprising: step of preparing a target raw material containing a target nuclide which Is a radionuclide, and a muon irradiation step for obtaining a first radionuclide through a muon nuclear capture reaction at the target nuclide by irradiating the target raw material with negative muons, wherein the radioactive substance to be produced comprises at least one of the first radionuclide and a second radionuclide, the second radionuclide being at least one descendant nuclide obtained from the first radionuclide via radioactive decay, wherein the target nuclide is at least one of descendant nuclides obtained from the first radionuclide or the second radionuclide via radioactive decay, and wherein the target raw material contains a recycled raw material that contains at least any of: a by-product in any step, a left over substance obtained from the radioactive substance, and a left over substance obtained from unused substance of the radioactive substance, the target nuclide being originated from the recycled raw material. step of preparing a target raw material containing a target nuclide which Is a radionuclide, and a muon irradiation step for obtaining a first radionuclide through a muon nuclear capture reaction at the target nuclide by irradiating the target raw material with negative muons, wherein the radioactive substance to be produced comprises at least one of the first radionuclide and a second radionuclide, the second radionuclide being at least one descendant nuclide obtained from the first radionuclide via radioactive decay, wherein the target nuclide is at least one of descendant nuclides obtained from the first radionuclide or the second radionuclide via radioactive decay, and wherein the target raw material contains a recycled raw material that contains at least any of: a by-product in any step, a left over substance obtained from the radioactive substance, and a left over substance obtained from unused substance of the radioactive substance, the target nuclide being originated from the recycled raw material.
Method for measuring Troponin I in a sample comprising at least the following steps: a) Contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label b) Contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface, or at least two different anti-Troponin I antibodies coupled to a sensor surface,wherein said antibodies of step a) and b) are directed at amino acid sequence 30-110 of Troponin I d) detecting the magnetic label on the sensor surface, wherein steps a) and b) can be performed in any order. a) Contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label b) Contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface, or at least two different anti-Troponin I antibodies coupled to a sensor surface,wherein said antibodies of step a) and b) are directed at amino acid sequence 30-110 of Troponin I d) detecting the magnetic label on the sensor surface,