A compound of Formula: or a stereoisomer, a tautomer, a solvate or a pharmaceutically acceptable salt thereof, wherein: L 1 is independently L 4 -O or O-L 4; L 2 is independently a hydrocarbon linker substituted with 0-2 R c, a hydrocarbon-heteroatom linker substituted with 0-2 R c, or -(CH 2) 1-2 -(C 3-4 cycloalkyl substituted with 0-2 R C)-(CH 2) 0-1 -; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, -CO-, S, -SO-, -SO 2, NH, N(C 1-4 alkyl), -CONH-, and -NHCO-; L 4 is independently a bond or a hydrocarbon linker; wherein said hydrocarbon linker has one to four carbon atoms and may be straight or branched; R 1 is independently selected from: C 6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein said carbocycle and heterocycle are substituted with 0-4 R 3 and 0-1 R 4; R 2 independently selected from: OH, CO 2 H, CO 2 (C 1-4 alkyl), CONR e NR f and -CONHSO 2 R f; R 3, at each occurrence, is independently selected from: halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 haloalkylthio, and NO 2; R 4 is independently -L 3 -R 5; L 3 is independently selected from: a bond, O, and C(=O); R 5 is independently selected from: phenyl and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein each ring moiety is substituted with 0-2 R a; R a, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R b, at each occurrence, is independently selected from: H, C 1-4 alkyl, and -(CH 2) 0-2 -(phenyl substituted with 0-3 R d); R c, at each occurrence, is independently selected from: =O, halogen, OH, C 1-4 alkyl, C 1-4 haloalkyl, and C 1-4 alkoxy; R d, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R e, at each occurrence, is independently selected from: H and C 1-4 alkyl; R f at each occurrence, is independently selected from: H, C 1-4 alkyl, -(CH 2) 0-2 -phenyl, and C 3-6 cycloalkyl substituted with 1-2 OH; R e and R f may be combined with the nitrogen atom to which they are attached to form a 4- to 6-membered heterocyclic ring comprising carbon atoms and 1 additional heteroatom selected from N, NR b, O, and S; wherein said heterocycle is substituted with and 0-1 OH; and p is, independently at each occurrence, selected from 0, 1, and 2. L 1 is independently L 4 -O or O-L 4; L 2 is independently a hydrocarbon linker substituted with 0-2 R c, a hydrocarbon-heteroatom linker substituted with 0-2 R c, or -(CH 2) 1-2 -(C 3-4 cycloalkyl substituted with 0-2 R C)-(CH 2) 0-1 -; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, -CO-, S, -SO-, -SO 2, NH, N(C 1-4 alkyl), -CONH-, and -NHCO-; L 4 is independently a bond or a hydrocarbon linker; wherein said hydrocarbon linker has one to four carbon atoms and may be straight or branched; R 1 is independently selected from: C 6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein said carbocycle and heterocycle are substituted with 0-4 R 3 and 0-1 R 4; R 2 independently selected from: OH, CO 2 H, CO 2 (C 1-4 alkyl), CONR e NR f and -CONHSO 2 R f; R 3, at each occurrence, is independently selected from: halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 haloalkylthio, and NO 2; R 4 is independently -L 3 -R 5; L 3 is independently selected from: a bond, O, and C(=O); R 5 is independently selected from: phenyl and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein each ring moiety is substituted with 0-2 R a; R a, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R b, at each occurrence, is independently selected from: H, C 1-4 alkyl, and -(CH 2) 0-2 -(phenyl substituted with 0-3 R d); R c, at each occurrence, is independently selected from: =O, halogen, OH, C 1-4 alkyl, C 1-4 haloalkyl, and C 1-4 alkoxy; R d, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R e, at each occurrence, is independently selected from: H and C 1-4 alkyl; R f at each occurrence, is independently selected from: H, C 1-4 alkyl, -(CH 2) 0-2 -phenyl, and C 3-6 cycloalkyl substituted with 1-2 OH; R e and R f may be combined with the nitrogen atom to which they are attached to form a 4- to 6-membered heterocyclic ring comprising carbon atoms and 1 additional heteroatom selected from N, NR b, O, and S; wherein said heterocycle is substituted with and 0-1 OH; and p is, independently at each occurrence, selected from 0, 1, and 2.