A portable handheld pressure support system configured to deliver a pressurized flow of breathable gas to the airway of a subject, the pressure support system comprising: a pressure generator configured to generate the pressurized flow of breathable gas; a subject interface configured to communicate the pressurized flow of breathable gas to the airway of the subject; one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; one or more processors configured to control operation of the pressure generator to generate the pressurized flow of breathable gas based on the output signals from the one or more sensors, according to a positive pressure support therapy regime; a portable power source configured to power the pressure generator, the one or more sensors, and the one or more processors; a housing configured to contain the pressure generator, the subject interface, the one or more sensors, the one or more processors, and the power source; and a handle attached to and/or formed by the housing and configured to be grasped by the subject to hold the housing in position with respect to the airway of the subject as the pressurized flow of breathable gas is delivered to the airway of the subject via the subject interface, wherein the one or more processors comprise, and are configured to execute, one or more computer program modules comprising a parameter module configured to determine, when executed by the one or more processors, one or more parameters within the system based on the output signals, wherein such one or more parameters include said one or more gas parameters, wherein the housing has a length running along a first axis from a first side to a second side, the housing has a width running along a second axis from a third side to a fourth side, the housing has a thickness running along a third axis from a fifth side toward a sixth side, characterised in that: the subject interface is located on the fifth side towards the first side, and the handle is formed in the housing on the sixth side toward the second side, opposite the subject interface. a pressure generator configured to generate the pressurized flow of breathable gas; a subject interface configured to communicate the pressurized flow of breathable gas to the airway of the subject; one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; one or more processors configured to control operation of the pressure generator to generate the pressurized flow of breathable gas based on the output signals from the one or more sensors, according to a positive pressure support therapy regime; a portable power source configured to power the pressure generator, the one or more sensors, and the one or more processors; a housing configured to contain the pressure generator, the subject interface, the one or more sensors, the one or more processors, and the power source; and a handle attached to and/or formed by the housing and configured to be grasped by the subject to hold the housing in position with respect to the airway of the subject as the pressurized flow of breathable gas is delivered to the airway of the subject via the subject interface, wherein the one or more processors comprise, and are configured to execute, one or more computer program modules comprising a parameter module configured to determine, when executed by the one or more processors, one or more parameters within the system based on the output signals, wherein such one or more parameters include said one or more gas parameters, wherein the housing has a length running along a first axis from a first side to a second side, the housing has a width running along a second axis from a third side to a fourth side, the housing has a thickness running along a third axis from a fifth side toward a sixth side, characterised in that: the subject interface is located on the fifth side towards the first side, and the handle is formed in the housing on the sixth side toward the second side, opposite the subject interface. the subject interface is located on the fifth side towards the first side, and the handle is formed in the housing on the sixth side toward the second side, opposite the subject interface.