An ultrasound imaging system configured to provide quantification of landmark mobility, the system comprising: a non-transitory computer readable medium encoded with instructions and configured to store a temporal sequence of image frames; and at least one processor in communication with the non-transitory computer readable medium and configured to execute the instructions, wherein when executed, the instructions cause the at least one processor to: determine whether one or more landmarks are present in individual image frames of the sequence of image frames; characterized in that the instructions cause the at least one processor to: output bounding boxes indicating locations of the one or more landmarks determined to be present in the individual image frames; output flow fields for the one or more landmarks determined to be present in the individual image frames based, at least in part, on the bounding boxes; generate values of displacement fields based, at least in part, on the flow fields; generate values of velocity vectors indicating direction and magnitude of motion based, at least in part, on the flow fields; calculate a displacement/velocity isotropy values by taking a ratio of a magnitude of spatially averaged displacement fields divided by the velocity vectors/magnitude of displacement fields; and generate (1016, 1018) at least one of a mobility map or a mobility index based, at least in part, on the displacement/velocity isotropy values. a non-transitory computer readable medium encoded with instructions and configured to store a temporal sequence of image frames; and at least one processor in communication with the non-transitory computer readable medium and configured to execute the instructions, wherein when executed, the instructions cause the at least one processor to: determine whether one or more landmarks are present in individual image frames of the sequence of image frames; characterized in that the instructions cause the at least one processor to: output bounding boxes indicating locations of the one or more landmarks determined to be present in the individual image frames; output flow fields for the one or more landmarks determined to be present in the individual image frames based, at least in part, on the bounding boxes; generate values of displacement fields based, at least in part, on the flow fields; generate values of velocity vectors indicating direction and magnitude of motion based, at least in part, on the flow fields; calculate a displacement/velocity isotropy values by taking a ratio of a magnitude of spatially averaged displacement fields divided by the velocity vectors/magnitude of displacement fields; and generate (1016, 1018) at least one of a mobility map or a mobility index based, at least in part, on the displacement/velocity isotropy values. determine whether one or more landmarks are present in individual image frames of the sequence of image frames; characterized in that the instructions cause the at least one processor to: output bounding boxes indicating locations of the one or more landmarks determined to be present in the individual image frames; output flow fields for the one or more landmarks determined to be present in the individual image frames based, at least in part, on the bounding boxes; generate values of displacement fields based, at least in part, on the flow fields; generate values of velocity vectors indicating direction and magnitude of motion based, at least in part, on the flow fields; calculate a displacement/velocity isotropy values by taking a ratio of a magnitude of spatially averaged displacement fields divided by the velocity vectors/magnitude of displacement fields; and generate (1016, 1018) at least one of a mobility map or a mobility index based, at least in part, on the displacement/velocity isotropy values. output bounding boxes indicating locations of the one or more landmarks determined to be present in the individual image frames; output flow fields for the one or more landmarks determined to be present in the individual image frames based, at least in part, on the bounding boxes; generate values of displacement fields based, at least in part, on the flow fields; generate values of velocity vectors indicating direction and magnitude of motion based, at least in part, on the flow fields; calculate a displacement/velocity isotropy values by taking a ratio of a magnitude of spatially averaged displacement fields divided by the velocity vectors/magnitude of displacement fields; and generate (1016, 1018) at least one of a mobility map or a mobility index based, at least in part, on the displacement/velocity isotropy values.