A human monoclonal antibody or fragment thereof comprising (a) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 19 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 21; (ii) an amino acid sequence as set out in SEQ ID NO: 22; (iii) an amino acid sequence as set out in SEQ ID NO: 52; and (iv) an amino acid sequence as set out in SEQ ID NO: 53; or (b) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 54 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 23; (ii) an amino acid sequence as set out in SEQ ID NO: 26; and (iii) an amino acid sequence as set out in SEQ ID NO: 28; or (c) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 55 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 21; and (ii) an amino acid sequence as set out in SEQ ID NO: 22; or (d) a light chain comprising an amino acid sequence as set out in SEQ ID NO: 34 and further comprising a heavy chain selected from: (i) an amino acid sequence as set out in SEQ ID NO: 35; (ii) an amino acid sequence as set out in SEQ ID NO: 37; (iii) an amino acid sequence as set out in SEQ ID NO: 40; (iv) an amino acid sequence as set out in SEQ ID NO: 42; and (v) an amino acid sequence as set out in SEQ ID NO: 48 (a) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 19 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 21; (ii) an amino acid sequence as set out in SEQ ID NO: 22; (iii) an amino acid sequence as set out in SEQ ID NO: 52; and (iv) an amino acid sequence as set out in SEQ ID NO: 53; or (i) an amino acid sequence as set out in SEQ ID NO: 21; (ii) an amino acid sequence as set out in SEQ ID NO: 22; (iii) an amino acid sequence as set out in SEQ ID NO: 52; and (iv) an amino acid sequence as set out in SEQ ID NO: 53; or (b) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 54 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 23; (ii) an amino acid sequence as set out in SEQ ID NO: 26; and (iii) an amino acid sequence as set out in SEQ ID NO: 28; or (i) an amino acid sequence as set out in SEQ ID NO: 23; (ii) an amino acid sequence as set out in SEQ ID NO: 26; and (iii) an amino acid sequence as set out in SEQ ID NO: 28; or (c) a light chain variable region comprising an amino acid sequence as set out in SEQ ID NO: 55 and further comprising a heavy chain variable region selected from: (i) an amino acid sequence as set out in SEQ ID NO: 21; and (ii) an amino acid sequence as set out in SEQ ID NO: 22; or (i) an amino acid sequence as set out in SEQ ID NO: 21; and (ii) an amino acid sequence as set out in SEQ ID NO: 22; or (d) a light chain comprising an amino acid sequence as set out in SEQ ID NO: 34 and further comprising a heavy chain selected from: (i) an amino acid sequence as set out in SEQ ID NO: 35; (ii) an amino acid sequence as set out in SEQ ID NO: 37; (iii) an amino acid sequence as set out in SEQ ID NO: 40; (iv) an amino acid sequence as set out in SEQ ID NO: 42; and (v) an amino acid sequence as set out in SEQ ID NO: 48 (i) an amino acid sequence as set out in SEQ ID NO: 35; (ii) an amino acid sequence as set out in SEQ ID NO: 37; (iii) an amino acid sequence as set out in SEQ ID NO: 40; (iv) an amino acid sequence as set out in SEQ ID NO: 42; and (v) an amino acid sequence as set out in SEQ ID NO: 48