A syringe assembly (44, 64, 90), comprising: a) a substantially cylindrical syringe barrel comprising a fluid dispensing end, an open end, and at least one protrusion adjacent the open end, the at least one protrusion projecting inwardly from an inner surface of the syringe barrel; b) a stopper (2, 66) configured to be received within the open end of the syringe barrel; and c) a plunger rod (40, 68, 92) having a plunger rod body (54, 74, 94, 96) extending along a longitudinal axis from a proximal end to a distal end and at least one support disk (56, 58, 76, 78, 98, 100) provided on the distal end thereof, wherein the at least one support disk (56, 58, 76, 78, 98, 100) on the plunger rod (40, 68, 92) is configured to bear against the protrusion of the syringe barrel upon misalignment of the plunger rod (40, 68, 92) in the syringe barrel, characterized in that: the at least one support disk (56, 58, 76, 78, 98, 100) comprises a first support disk (56, 76, 98) and a second support disk (58, 78, 100) on the plunger rod (40, 68, 92) spaced from one another such that, when the plunger rod (40, 68, 92) is misaligned in the syringe barrel, the first support disk (56, 76, 98) bears against a proximal side of the protrusion at a first load bearing point and the second support disk (58, 78, 100) bears against a distal side of the protrusion at a second load bearing point. a) a substantially cylindrical syringe barrel comprising a fluid dispensing end, an open end, and at least one protrusion adjacent the open end, the at least one protrusion projecting inwardly from an inner surface of the syringe barrel; b) a stopper (2, 66) configured to be received within the open end of the syringe barrel; and c) a plunger rod (40, 68, 92) having a plunger rod body (54, 74, 94, 96) extending along a longitudinal axis from a proximal end to a distal end and at least one support disk (56, 58, 76, 78, 98, 100) provided on the distal end thereof, wherein the at least one support disk (56, 58, 76, 78, 98, 100) on the plunger rod (40, 68, 92) is configured to bear against the protrusion of the syringe barrel upon misalignment of the plunger rod (40, 68, 92) in the syringe barrel, characterized in that: the at least one support disk (56, 58, 76, 78, 98, 100) comprises a first support disk (56, 76, 98) and a second support disk (58, 78, 100) on the plunger rod (40, 68, 92) spaced from one another such that, when the plunger rod (40, 68, 92) is misaligned in the syringe barrel, the first support disk (56, 76, 98) bears against a proximal side of the protrusion at a first load bearing point and the second support disk (58, 78, 100) bears against a distal side of the protrusion at a second load bearing point. wherein the at least one support disk (56, 58, 76, 78, 98, 100) on the plunger rod (40, 68, 92) is configured to bear against the protrusion of the syringe barrel upon misalignment of the plunger rod (40, 68, 92) in the syringe barrel, characterized in that: the at least one support disk (56, 58, 76, 78, 98, 100) comprises a first support disk (56, 76, 98) and a second support disk (58, 78, 100) on the plunger rod (40, 68, 92) spaced from one another such that, when the plunger rod (40, 68, 92) is misaligned in the syringe barrel, the first support disk (56, 76, 98) bears against a proximal side of the protrusion at a first load bearing point and the second support disk (58, 78, 100) bears against a distal side of the protrusion at a second load bearing point.