A touch signal detection circuit, comprising a processing unit, at least one linear transmitting electrode, and at least two linear receiving electrodes, wherein: the transmitting electrode is perpendicular to the at least two receiving electrodes, the at least two receiving electrodes are perpendicular to a source driver line of a display screen, and each of the at least two receiving electrodes and each transmitting electrode form one node mutual capacitance; and the processing unit is configured to acquire capacitance change values of at least two node mutual capacitances, and acquire a location of a touch signal according to the capacitance change values of the at least two node mutual capacitances; wherein the processing unit is specifically configured to collect statistics on the capacitance change values of the at least two node mutual capacitances, determine an interference value according to a statistical result when the touch signal detection circuit performs detection on a touch location, and determine the location of the touch signal according to the interference value and the capacitance change values; and characterised in that the processing unit is specifically configured to divide the capacitance change values into two groups according to a numerical range of the capacitance change values, use an average value of all capacitance change values in one group that comprises a larger number of capacitance change values as the interference value, obtain a data value by subtracting the interference value from each of the capacitance change values, and take a location, at which the data value is greater than a preset value, of a node mutual capacitance as the location of the touch signal. the transmitting electrode is perpendicular to the at least two receiving electrodes, the at least two receiving electrodes are perpendicular to a source driver line of a display screen, and each of the at least two receiving electrodes and each transmitting electrode form one node mutual capacitance; and the processing unit is configured to acquire capacitance change values of at least two node mutual capacitances, and acquire a location of a touch signal according to the capacitance change values of the at least two node mutual capacitances; wherein the processing unit is specifically configured to collect statistics on the capacitance change values of the at least two node mutual capacitances, determine an interference value according to a statistical result when the touch signal detection circuit performs detection on a touch location, and determine the location of the touch signal according to the interference value and the capacitance change values; and characterised in that the processing unit is specifically configured to divide the capacitance change values into two groups according to a numerical range of the capacitance change values, use an average value of all capacitance change values in one group that comprises a larger number of capacitance change values as the interference value, obtain a data value by subtracting the interference value from each of the capacitance change values, and take a location, at which the data value is greater than a preset value, of a node mutual capacitance as the location of the touch signal.