A compound of Formula I, or a stereoisomer, a tautomer, a polymorph, a solvate, or a pharmaceutically acceptable salt thereof, wherein, ring A is aryl or heteroaryl; Z is selected from the group consisting of CH 2, NH, O and S; R 1 is independently selected from the group consisting of hydrogen, halogen, CN, NO 2, OH, NH 2, C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-(CH 2) m -, aryl-C 1-6 alkyl-, heteroaryl-C 1-6 alkyl-, -NR 12 R 13, -NR 12 -C 1-6 alkylene-NR 12 R 13, and heterocyclyl-C -, wherein the C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-(CH 2) m -, aryl-C 1-6 alkyl-, heteroaryl-C 1-6 alkyl-, or heterocyclyl-C - are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, heterocyclyl, -NR 12 R 13, or -(CH 2) t -OH; R 2 and R 3 are each independently selected from H, OH, CN, NO 2, NH 2, halogen, C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl; wherein the C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, or heterocyclyl; R 12 and R 13 are each independently selected from H, C 1-8 alkyl, aryl, heteroaryl, heterocyclyl, C 3-8 cycloalkyl; wherein the C 1-8 alkyl, aryl, heteroaryl, heterocyclyl, or C 3-8 cycloalkyl are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, or heterocyclyl; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; t is 0, 1, 2, 3 or 4; aryl is mono cyclic or bicyclic 6-10 membered aromatic ring systems; heteroaryl is an unsubstituted or substituted stable five or six membered monocyclic aromatic ring system or an unsubstituted or substituted nine or ten membered benzo-fused heteroaromatic ring system or bicyclic heteroaromatic ring system which consists of carbon atoms and from one to four heteroatoms selected from N, O or S; and heterocyclyl is an unsubstituted or substituted stable three to eight membered monocyclic saturated ring system which consists of carbon atoms and from one to three heteroatoms selected from N, O or S. ring A is aryl or heteroaryl; Z is selected from the group consisting of CH 2, NH, O and S; R 1 is independently selected from the group consisting of hydrogen, halogen, CN, NO 2, OH, NH 2, C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-(CH 2) m -, aryl-C 1-6 alkyl-, heteroaryl-C 1-6 alkyl-, -NR 12 R 13, -NR 12 -C 1-6 alkylene-NR 12 R 13, and heterocyclyl-C -, wherein the C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-(CH 2) m -, aryl-C 1-6 alkyl-, heteroaryl-C 1-6 alkyl-, or heterocyclyl-C - are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, heterocyclyl, -NR 12 R 13, or -(CH 2) t -OH; R 2 and R 3 are each independently selected from H, OH, CN, NO 2, NH 2, halogen, C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl; wherein the C 1-8 alkyl, C 1-8 alkoxy, C 3-8 cycloalkyl, aryl, heteroaryl, heterocyclyl are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, or heterocyclyl; R 12 and R 13 are each independently selected from H, C 1-8 alkyl, aryl, heteroaryl, heterocyclyl, C 3-8 cycloalkyl; wherein the C 1-8 alkyl, aryl, heteroaryl, heterocyclyl, or C 3-8 cycloalkyl are each unsubstituted or substituted with at least one substituent selected from halogen, hydroxyl, C 1-8 alkyl, C 3-8 cycloalkyl, or heterocyclyl; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; t is 0, 1, 2, 3 or 4; aryl is mono cyclic or bicyclic 6-10 membered aromatic ring systems; heteroaryl is an unsubstituted or substituted stable five or six membered monocyclic aromatic ring system or an unsubstituted or substituted nine or ten membered benzo-fused heteroaromatic ring system or bicyclic heteroaromatic ring system which consists of carbon atoms and from one to four heteroatoms selected from N, O or S; and heterocyclyl is an unsubstituted or substituted stable three to eight membered monocyclic saturated ring system which consists of carbon atoms and from one to three heteroatoms selected from N, O or S.