A liquid transfer device for use with an IV bottle, an additive transfer device and an infusion set with an IV spike for intravenous administration of infusion liquid to a patient, an IV bottle having a closed end and tapering towards an open IV bottle neck and containing infusion liquid, and an IV bottle crown mounted on the IV bottle neck and having an IV bottle stopper for sealing the IV bottle, the additive transfer device having a male connector, the liquid transfer device having a longitudinal liquid transfer device centerline and comprising: a) a vial adapter having a transverse vial adapter top surface and a downward depending vial adapter skirt configured to telescopically mount on the IV bottle crown, said vial adapter having a cannula configured to puncture the IV bottle stopper for fluid communication with the IV bottle upon mounting on the IV bottle crown, said transverse vial adapter top surface having an upright nipple oppositely directed with respect to said cannula, said nipple having a first nipple section with a first nipple section lumen in fluid communication with a cannula lumen of said cannula, and said nipple having a second nipple section with a second nipple section lumen in fluid communication with said cannula lumen; b) an IV port extending from said first nipple section and including a sealing membrane comprising a material puncturable by the IV spike of the infusion set; and c) a needleless self-sealing port extending from said second nipple section, said needleless self-sealing port configured to couple with the male connector of the additive transfer device. an IV bottle having a closed end and tapering towards an open IV bottle neck and containing infusion liquid, and an IV bottle crown mounted on the IV bottle neck and having an IV bottle stopper for sealing the IV bottle, the additive transfer device having a male connector, the liquid transfer device having a longitudinal liquid transfer device centerline and comprising: a) a vial adapter having a transverse vial adapter top surface and a downward depending vial adapter skirt configured to telescopically mount on the IV bottle crown, said vial adapter having a cannula configured to puncture the IV bottle stopper for fluid communication with the IV bottle upon mounting on the IV bottle crown, said transverse vial adapter top surface having an upright nipple oppositely directed with respect to said cannula, said nipple having a first nipple section with a first nipple section lumen in fluid communication with a cannula lumen of said cannula, and said nipple having a second nipple section with a second nipple section lumen in fluid communication with said cannula lumen; b) an IV port extending from said first nipple section and including a sealing membrane comprising a material puncturable by the IV spike of the infusion set; and c) a needleless self-sealing port extending from said second nipple section, said needleless self-sealing port configured to couple with the male connector of the additive transfer device. a) a vial adapter having a transverse vial adapter top surface and a downward depending vial adapter skirt configured to telescopically mount on the IV bottle crown, said vial adapter having a cannula configured to puncture the IV bottle stopper for fluid communication with the IV bottle upon mounting on the IV bottle crown, said transverse vial adapter top surface having an upright nipple oppositely directed with respect to said cannula, said nipple having a first nipple section with a first nipple section lumen in fluid communication with a cannula lumen of said cannula, and said nipple having a second nipple section with a second nipple section lumen in fluid communication with said cannula lumen; said transverse vial adapter top surface having an upright nipple oppositely directed with respect to said cannula, said nipple having a first nipple section with a first nipple section lumen in fluid communication with a cannula lumen of said cannula, and said nipple having a second nipple section with a second nipple section lumen in fluid communication with said cannula lumen; b) an IV port extending from said first nipple section and including a sealing membrane comprising a material puncturable by the IV spike of the infusion set; and c) a needleless self-sealing port extending from said second nipple section, said needleless self-sealing port configured to couple with the male connector of the additive transfer device.