A combination of a disinfection cap and a needleless connector comprising a mating feature, the disinfection cap comprising: a housing (302, 802, 1102) comprising a closed top (322, 822, 1122), an essentially cylindrical sidewall (304, 804, 1104), and an open bottom (324, 824, 1124) formed by said sidewall with an opening (326, 826, 1126) to an inner cavity (328, 828, 1128) within said housing for receiving a tip including a mating feature of a needleless connector; a disinfection sponge (380, 880, 1180) configured within said inner cavity; and a removable cover (399, 899, 1199) sealing said opening to said inner cavity to seal said sponge within said inner cavity prior to use of said cap, wherein said inner cavity comprises at least one cap thread (340, 840, 1140) on an inner sidewall surface (330, 830, 1130) of said sidewall, said cap thread (340, 840, 1140) being sufficient to interlock with said mating feature of said needleless connector, said open bottom does not form an airtight seal with an outer surface of said needleless connector when said cap thread (340, 840, 1140) interlocks with said mating feature of said needleless connector, characterized in that said cap thread does not correspond to said mating feature of said needleless connector, a portion of said at least one cap thread (340, 840, 1140) comprising a non-engaging portion that does not engage said mating feature of said needleless connector, achieving at least one venting path (311, 811, 1111) between said cap thread (340, 840, 1140) and said mating feature of said needless connector from said inner cavity (328, 828, 1128) to outside of said housing (302, 802, 1102) when said cap thread (340, 840, 1140) interlocks with said mating feature of said needleless connector. a housing (302, 802, 1102) comprising a closed top (322, 822, 1122), an essentially cylindrical sidewall (304, 804, 1104), and an open bottom (324, 824, 1124) formed by said sidewall with an opening (326, 826, 1126) to an inner cavity (328, 828, 1128) within said housing for receiving a tip including a mating feature of a needleless connector; a disinfection sponge (380, 880, 1180) configured within said inner cavity; and a removable cover (399, 899, 1199) sealing said opening to said inner cavity to seal said sponge within said inner cavity prior to use of said cap, wherein said inner cavity comprises at least one cap thread (340, 840, 1140) on an inner sidewall surface (330, 830, 1130) of said sidewall, said cap thread (340, 840, 1140) being sufficient to interlock with said mating feature of said needleless connector, said open bottom does not form an airtight seal with an outer surface of said needleless connector when said cap thread (340, 840, 1140) interlocks with said mating feature of said needleless connector, characterized in that said cap thread does not correspond to said mating feature of said needleless connector, a portion of said at least one cap thread (340, 840, 1140) comprising a non-engaging portion that does not engage said mating feature of said needleless connector, achieving at least one venting path (311, 811, 1111) between said cap thread (340, 840, 1140) and said mating feature of said needless connector from said inner cavity (328, 828, 1128) to outside of said housing (302, 802, 1102) when said cap thread (340, 840, 1140) interlocks with said mating feature of said needleless connector.