A materials screening system comprising: a scan region configured to receive an object; a source of radiation configured to illuminate the scan region; a sensor configured to sense radiation from the scan region; a processor; a computer-readable storage medium storing instructions for generating a two-dimensional image of the object of interest, the instructions, when executed, cause the processor to perform the following: generate a volumetric image of the scan region based on the sensed radiation, the volumetric image including a representation of an object of interest and another object, generate a two-dimensional radiograph of the scan region based on the sensed radiation, the two-dimensional radiograph including a representation of the object of interest and the other object, analyze the volumetric image to identify the object of interest or the other object in the volumetric image, based on the analyzed volumetric image, generate a two-dimensional image that excludes the object of interest, characterized in that the instructions, when executed, further cause the processor to perform the following: compare the two-dimensional radiograph and the two-dimensional image that was generated based on the analyzed volumetric image and that excludes the identified object of interest, and generate a two-dimensional image based on the comparison, the two-dimensional image including the object of interest and excluding the other object. a scan region configured to receive an object; a source of radiation configured to illuminate the scan region; a sensor configured to sense radiation from the scan region; a processor; a computer-readable storage medium storing instructions for generating a two-dimensional image of the object of interest, the instructions, when executed, cause the processor to perform the following: generate a volumetric image of the scan region based on the sensed radiation, the volumetric image including a representation of an object of interest and another object, generate a two-dimensional radiograph of the scan region based on the sensed radiation, the two-dimensional radiograph including a representation of the object of interest and the other object, analyze the volumetric image to identify the object of interest or the other object in the volumetric image, based on the analyzed volumetric image, generate a two-dimensional image that excludes the object of interest, generate a volumetric image of the scan region based on the sensed radiation, the volumetric image including a representation of an object of interest and another object, generate a two-dimensional radiograph of the scan region based on the sensed radiation, the two-dimensional radiograph including a representation of the object of interest and the other object, analyze the volumetric image to identify the object of interest or the other object in the volumetric image, based on the analyzed volumetric image, generate a two-dimensional image that excludes the object of interest, characterized in that the instructions, when executed, further cause the processor to perform the following: compare the two-dimensional radiograph and the two-dimensional image that was generated based on the analyzed volumetric image and that excludes the identified object of interest, and generate a two-dimensional image based on the comparison, the two-dimensional image including the object of interest and excluding the other object. compare the two-dimensional radiograph and the two-dimensional image that was generated based on the analyzed volumetric image and that excludes the identified object of interest, and generate a two-dimensional image based on the comparison, the two-dimensional image including the object of interest and excluding the other object.