A targeting guide (5200; 4300) for use with a volar distal radius plate, comprising: - a body having an upper portion configured to be disposed on a head portion of the volar distal radius plate and a lower portion configured to couple the targeting guide (5200; 4300) to the volar distal radius plate; - a plurality of cannulated openings corresponding to respective openings of the volar distal radius plate, wherein the cannulated openings are configured to facilitate drilling pilot holes and inserting fasteners at desired trajectories through the openings of the volar distal radius plate; - a counterbored hole extending through the body; - a retaining arm disposed adjacent the counterbored hole and extending from the lower portion of the body and into an opening in the volar distal radius plate, wherein the retaining arm includes a detent configured to receive and mate with a portion of the opening of the volar distal radius plate and a flange extending radially outward from a distal end of the retaining arm; and - a cam screw disposed through the counterbored hole, wherein the cam screw includes a head and a shaft extending from the head, wherein the shaft includes a radially outwardly extending flange extending from a distal end of the shaft, characterized in that - the head includes a cam surface that extends radially from the head in a direction opposite to the radially outwardly extending flange, - wherein when the cam screw is moveable between an unlocked position, in which the targeting guide (5200; 4300) inserted into and removed from the volar distal radius plate, and a locked position, in which the targeting guide (5200; 4300) is locked onto the volar distal radius plate. - a body having an upper portion configured to be disposed on a head portion of the volar distal radius plate and a lower portion configured to couple the targeting guide (5200; 4300) to the volar distal radius plate; - a plurality of cannulated openings corresponding to respective openings of the volar distal radius plate, wherein the cannulated openings are configured to facilitate drilling pilot holes and inserting fasteners at desired trajectories through the openings of the volar distal radius plate; - a counterbored hole extending through the body; - a retaining arm disposed adjacent the counterbored hole and extending from the lower portion of the body and into an opening in the volar distal radius plate, wherein the retaining arm includes a detent configured to receive and mate with a portion of the opening of the volar distal radius plate and a flange extending radially outward from a distal end of the retaining arm; and - a cam screw disposed through the counterbored hole, wherein the cam screw includes a head and a shaft extending from the head, wherein the shaft includes a radially outwardly extending flange extending from a distal end of the shaft, characterized in that - the head includes a cam surface that extends radially from the head in a direction opposite to the radially outwardly extending flange, - wherein when the cam screw is moveable between an unlocked position, in which the targeting guide (5200; 4300) inserted into and removed from the volar distal radius plate, and a locked position, in which the targeting guide (5200; 4300) is locked onto the volar distal radius plate.