mhurhangee/ep-ind-claims huggingface dataset:
A compound of general formula R 1 -S-CH 2 -OXA-R 2 including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable cocrystals or salts, and complexes thereof; wherein OXA is 1,3-oxazolyl; the group R 1 -S-CH 2 is bound to C 2 of the 1,3-oxazolyl and the group R 2 is bound to C 4 of the 1,3-oxazolyl; R 1 is a 6 membered heteroaryl group selected from the group consisting of 1,3,5-triazinyl and pyrimidinyl being independently substituted with one or more substituents selected from the group consisting of hydroxyl, amino, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, N-mono- or N,N-di-substituted C 1 -C 3 -alkylamino, nonaromatic 5- to 6-membered heterocyclyl, 6-membered aryl and 5- to 6-membered heteroaryl which substituents may be unsubstituted or substituted with one or more groups selected from the group consisting of halide, cyano and C 1 -C 6 -alkyl, wherein the 6-membered aryl and 5- to 6-membered heteroaryl group, respectively, may be fused to said 1,3,5-triazinyl or pyrimidyl group, respectively, and R 2 is phenyl being unsubstituted or being substituted with one or more substituents selected from the group consisting of halide, cyano, amino, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl which may be optionally substituted with one or more halides, C 1 -C 4 -alkoxy which may optionally substituted with one or more halides, hydroxy-C 1 -C 6 -alkyl, sulfonyl-C 1 -C 6 -alkyl, sulphamidyl-N-C 1 -C6-alkyl and carboxamidyl-N-mono- or - N,N-di-C 1 -C 6 -alkyl; with the proviso that the following compounds are excluded: including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable cocrystals or salts, and complexes thereof; wherein OXA is 1,3-oxazolyl; the group R 1 -S-CH 2 is bound to C 2 of the 1,3-oxazolyl and the group R 2 is bound to C 4 of the 1,3-oxazolyl; R 1 is a 6 membered heteroaryl group selected from the group consisting of 1,3,5-triazinyl and pyrimidinyl being independently substituted with one or more substituents selected from the group consisting of hydroxyl, amino, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, N-mono- or N,N-di-substituted C 1 -C 3 -alkylamino, nonaromatic 5- to 6-membered heterocyclyl, 6-membered aryl and 5- to 6-membered heteroaryl which substituents may be unsubstituted or substituted with one or more groups selected from the group consisting of halide, cyano and C 1 -C 6 -alkyl, wherein the 6-membered aryl and 5- to 6-membered heteroaryl group, respectively, may be fused to said 1,3,5-triazinyl or pyrimidyl group, respectively, and R 2 is phenyl being unsubstituted or being substituted with one or more substituents selected from the group consisting of halide, cyano, amino, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl which may be optionally substituted with one or more halides, C 1 -C 4 -alkoxy which may optionally substituted with one or more halides, hydroxy-C 1 -C 6 -alkyl, sulfonyl-C 1 -C 6 -alkyl, sulphamidyl-N-C 1 -C6-alkyl and carboxamidyl-N-mono- or - N,N-di-C 1 -C 6 -alkyl; with the proviso that the following compounds are excluded:
A method of dispersing and hydrating a water soluble polymer, comprising: forming a nonaqueous slurry of one or more polyethers, one or more water soluble polymers, and hydrophobically modified ethoxylated urethane, provided that the slurry contains less than five percent water; and then contacting the nonaqueous slurry with water to disperse and hydrate the water soluble polymer, with the exception of methods comprising forming the nonaqueous slurry of polypropylene glycol, water soluble polymer, and hydrophobically modified ethoxylated urethane. forming a nonaqueous slurry of one or more polyethers, one or more water soluble polymers, and hydrophobically modified ethoxylated urethane, provided that the slurry contains less than five percent water; and then contacting the nonaqueous slurry with water to disperse and hydrate the water soluble polymer, with the exception of methods comprising forming the nonaqueous slurry of polypropylene glycol, water soluble polymer, and hydrophobically modified ethoxylated urethane.
Ground-working machine having at least two elongate drilling and mixing tools arranged parallel to each other, which comprise a rod-form base body, on which a first screw conveyor and at least one second screw conveyor are arranged, the second screw conveyor being axially spaced apart from the first screw conveyor, wherein at least on one drilling and mixing tool at a lower end the first screw conveyor is formed with an outer diameter that is greater than an outer diameter of the second screw conveyor, which is arranged above the first screw conveyor. characterised in that at least one transverse yoke (12, 14) is arranged between the lower first screw conveyor and the upper second screw conveyor, the transverse yoke connecting the drilling and mixing tools to each other, that two drilling and mixing tools are provided, between which a rod-form intermediate element is arranged, which has a screw conveyor in its upper area, and that the intermediate element has, at least in its lower area, a smaller outer diameter than the neighbouring drilling and mixing tools.
Luer connection as a connecting system for lines in the medical sector, in particular for fluid, vacuum and compressed air lines, with a first male connecting element that has a distal connecting region and a second female connecting element that has a distal receiving region, wherein the connecting region can be inserted into the receiving region, so that a strong connection is made between the male connecting element and the female connecting element, wherein the connecting region has an encoding collar and the receiving region has an encoding surface corresponding to the encoding collar, wherein the encoding collar has on its inner side at least one encoding element formed as a rib, that the encoding surface is formed by grooves, that, in the connected state, the rib is pressed on to the surface of the receiving region such that the female connecting element is jammed on the inner side with the male connecting element and on the outer side with the encoding collar, c h a r a c t e r i s e d in that the grooves are tapered in the end region.
Medical instrument for guiding a tool into an operating space, with - a shaft, which has a first shaft segment (20, 21, 22) and a second shaft segment (20, 21, 22) connected to each other in an articulated manner (3, 3A, 3B), and - an adjustment element (5, 5A, 5B), which is guided longitudinally movably in an inner bore of the first shaft segment or second shaft segment (20, 21, 22) and is adjustable along an adjustment direction, in order to pivot the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) relative to each other, and - a connection element (4, 4A, 4B), which is connected in an articulated manner to the adjustment element (5, 5A) via a first hinge connection (40, 41, 40A, 40B, 41A, 41B, 42) and is connected in an articulated manner to the other of the first and second shaft segments (20, 21, 22) via a second hinge connection (40, 41, 40A, 40B, 41A, 41B, 42), wherein, by adjusting the adjustment element (5, 5A, 5B) along the adjustment direction, the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) are pivotable relative to each other, wherein the adjustment element (5, 5A, 5B) is designed to pivot the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) between a longitudinal extension state, in which the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) are aligned substantially collinearly with each other, and a pivoted state, in which the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) are pivoted from the longitudinal extension state. characterized in that the connection element (4, 4A, 4B) is designed as a semicylindrically shaped half-tube and has an inner bearing surface, on which at least one of the first and second shaft segments (20, 21, 22) bears in the longitudinal extension state. - a shaft, which has a first shaft segment (20, 21, 22) and a second shaft segment (20, 21, 22) connected to each other in an articulated manner (3, 3A, 3B), and - an adjustment element (5, 5A, 5B), which is guided longitudinally movably in an inner bore of the first shaft segment or second shaft segment (20, 21, 22) and is adjustable along an adjustment direction, in order to pivot the first shaft segment (20, 21, 22) and the second shaft segment (20, 21, 22) relative to each other, and - a connection element (4, 4A, 4B), which is connected in an articulated manner to the adjustment element (5, 5A) via a first hinge connection (40, 41, 40A, 40B, 41A, 41B, 42) and is connected in an articulated manner to the other of the first and second shaft segments (20, 21, 22) via a second hinge connection (40, 41, 40A, 40B, 41A, 41B, 42),
A device for the machining of curved laminar surfaces that have a concave face (1.1) to be machined with a radius of curvature (r) and a convex face (1.2) opposite the concave face (1.1), the device for machining comprising: - a first part including a tool configured for machining the concave face (1.1) of the curved laminar surface, and first pressure means configured to come into contact with the concave face (1.1) of the curved laminar surface, - a second part including second pressure means configured to come into contact with the convex face (1.2) of the curved laminar surface, and - synchronisation means for synchronising the movements of the first part and the second part of the device for machining, such that when used, both parts (2, 3) move opposite to each other and in a synchronised way, characterised in that the tool of the first part has a circular shape for the radial machining of the concave face (1.1) of the curved laminar surface, and that the first pressure means comprise at least one disc that is parallel to the tool, wherein the tool and the at least one disc are disposed on a rotary shaft, and both have a radius equal to or less than the radius of curvature (r) of the concave face (1.1) of the curved laminar surface. - a first part including a tool configured for machining the concave face (1.1) of the curved laminar surface, and first pressure means configured to come into contact with the concave face (1.1) of the curved laminar surface, - a second part including second pressure means configured to come into contact with the convex face (1.2) of the curved laminar surface, and - synchronisation means for synchronising the movements of the first part and the second part of the device for machining, such that when used, both parts (2, 3) move opposite to each other and in a synchronised way, characterised in that the tool of the first part has a circular shape for the radial machining of the concave face (1.1) of the curved laminar surface, and that the first pressure means comprise at least one disc that is parallel to the tool, wherein the tool and the at least one disc are disposed on a rotary shaft, and both have a radius equal to or less than the radius of curvature (r) of the concave face (1.1) of the curved laminar surface.
An in vitro method for enriching for a population of solid tumor stem cells, comprising the steps of: (a) dissociating a solid tumor of epithelial cancer; (b) contacting the dissociated cells with a first reagent that binds CD44 and a second reagent that binds CD24; and (c) selecting cells that bind to the first reagent and that do not detectably bind or bind poorly to the second reagent, wherein the selected cells are enriched in tumor stem cells. (a) dissociating a solid tumor of epithelial cancer; (b) contacting the dissociated cells with a first reagent that binds CD44 and a second reagent that binds CD24; and (c) selecting cells that bind to the first reagent and that do not detectably bind or bind poorly to the second reagent, wherein the selected cells are enriched in tumor stem cells.
A catheter assembly (10A-10G) comprising: a catheter (12, 60, 82, 112, 146, 174, 200, 250, 261, 270, 280, 300) having a distal opening (12b, 60b, 82b, 112b, 146b, 174b, 200b); an inner needle (16, 66, 88, 118, 150, 180, 206, 252) inserted through the catheter; and a deflection suppression mechanism (20, 70, 90, 126, 158, 186, 214) that supports the inner needle via the catheter to suppress a deflection of the inner needle, wherein the deflection suppression mechanism has a sliding contact support portion (54, 80, 100, 140, 172, 234) that is capable of supporting the catheter while rubbing against the catheter when the catheter is advanced with respect to the inner needle, characterized in that the catheter is provided with a side flow path structure (22, 72, 92, 128, 160, 188, 216), which has at least one liquid passage that allows passage of a liquid between an inside and an outside of the catheter, on a circumferential wall, and the sliding contact support portion is located to be closer to a proximal side than a liquid passage located on a most distal side of the side flow path structure in an initial state before the catheter is advanced with respect to the inner needle, wherein the deflection suppression mechanism has a lower support member that supports the catheter from a lower side, the lower support member has the sliding contact support portion, and the side flow path structure is provided only in a lower portion of the catheter. a catheter (12, 60, 82, 112, 146, 174, 200, 250, 261, 270, 280, 300) having a distal opening (12b, 60b, 82b, 112b, 146b, 174b, 200b); an inner needle (16, 66, 88, 118, 150, 180, 206, 252) inserted through the catheter; and a deflection suppression mechanism (20, 70, 90, 126, 158, 186, 214) that supports the inner needle via the catheter to suppress a deflection of the inner needle, wherein the deflection suppression mechanism has a sliding contact support portion (54, 80, 100, 140, 172, 234) that is capable of supporting the catheter while rubbing against the catheter when the catheter is advanced with respect to the inner needle, characterized in that the catheter is provided with a side flow path structure (22, 72, 92, 128, 160, 188, 216), which has at least one liquid passage that allows passage of a liquid between an inside and an outside of the catheter, on a circumferential wall, and the sliding contact support portion is located to be closer to a proximal side than a liquid passage located on a most distal side of the side flow path structure in an initial state before the catheter is advanced with respect to the inner needle, wherein the deflection suppression mechanism has a lower support member that supports the catheter from a lower side, the lower support member has the sliding contact support portion, and the side flow path structure is provided only in a lower portion of the catheter.
A method of determining a position of a downhole tool with respect to a wellbore, comprising: logging well data via the tool over a period of time; measuring a lateral acceleration of the tool over the period of time with one or more accelerometers embedded in the tool; and characterized by: double integrating the measured acceleration of the tool over the period of time; obtaining a displacement (502a, 502b) of the tool over the period of time from the double integration; fitting the displacement of the tool over the period of time to a best fit curve (504a, 504b), the best fit curve (504a,b) indicative of a lateral deviation of the wellbore; subtracting the best fit curve (504a,b) from the displacement (502a,b) of the tool over the period of time, the difference between the best fit curve and the displacement of the tool indicative of the position of the tool relative to the wellbore; and associating the logged well data with the position of the tool relative to the wellbore, generating calibrated logging data and forming a wellbore image therefrom. logging well data via the tool over a period of time; measuring a lateral acceleration of the tool over the period of time with one or more accelerometers embedded in the tool; double integrating the measured acceleration of the tool over the period of time; obtaining a displacement (502a, 502b) of the tool over the period of time from the double integration; fitting the displacement of the tool over the period of time to a best fit curve (504a, 504b), the best fit curve (504a,b) indicative of a lateral deviation of the wellbore; subtracting the best fit curve (504a,b) from the displacement (502a,b) of the tool over the period of time, the difference between the best fit curve and the displacement of the tool indicative of the position of the tool relative to the wellbore; and
Gas burner for a household cooking appliance with a burner housing, which has a mixing chamber for mixing of fuel gas with primary air, and a gas nozzle accommodated in the burner housing for injecting the fuel gas into the mixing chamber, wherein an annular first primary air inlet for drawing in the primary air is provided between the gas nozzle and the mixing chamber, wherein the gas nozzle has a second primary air inlet guided through said nozzle for drawing in the primary air, wherein the second primary air inlet, in the direction of flow of the primary air through the second primary air inlet tapers at least once and widens out again and wherein the gas nozzle has an annular fuel gas outlet opening which opens directly into the second primary air inlet.
A blood brain barrier shuttle comprising a brain effector entity and a brain targeting peptide comprising a three amino acid motif, wherein the brain targeting peptide comprising a three amino acid peptide motif has Seq. Id. No. 8, wherein the brain effector entity is selected from the group of proteins, polypeptides and peptides.
Cage component for an anti-friction bearing having a first section for guiding rolling bodies with respect to a bearing ring, and a second section which adjoins the first section in the axial direction, elastic webs with latching lugs being provided on the second section, which webs delimit the first section, the webs extending substantially in the tangential direction.
An automated tying tool, characterized by comprising: a slider, a guide rail, a first guide claw, a second guide claw, a frame, a tensioning wheel, a cutter, a stepping feeding mechanism 2., wherein the first guide claw and the second guide claw are mounted on the frame via a rotation-center pin, the cutter and the tensioning wheel are mounted in the frame, the guide rail is adjacent closely to the frame, the slider is adapted to cooperate with the guide rail and to slide along a length direction of the guide rail, the first guide claw, the second guide claw, the slider and the guide rail are arranged to have symmetrical center planes located on a center plane of the automated tying tool, the stepping feeding mechanism is mounted on the frame or mounted on a housing of the automated tying tool, the stepping feeding mechanism is capable of loading a tie, and the tie is conveyed, in each binding cycle, according to a fixed interval, to a position where a symmetrical center plane of the tie is coincident with a center plane of the automated tying tool, wherein the automatic tying tool is characterized by further comprising a material pushing rod which is mounted on the frame or the housing of the automated tying tool, the material pushing rod is adapted to push the tie located on the center plane of the automated tying tool to the slider to be pre-positioned, and the slider is adapted to drive the tie to slide from the pre-positioning position to a binding operation position. wherein the first guide claw and the second guide claw are mounted on the frame via a rotation-center pin, the cutter and the tensioning wheel are mounted in the frame, the guide rail is adjacent closely to the frame, the slider is adapted to cooperate with the guide rail and to slide along a length direction of the guide rail, the first guide claw, the second guide claw, the slider and the guide rail are arranged to have symmetrical center planes located on a center plane of the automated tying tool, the stepping feeding mechanism is mounted on the frame or mounted on a housing of the automated tying tool, the stepping feeding mechanism is capable of loading a tie, and the tie is conveyed, in each binding cycle, according to a fixed interval, to a position where a symmetrical center plane of the tie is coincident with a center plane of the automated tying tool, wherein the automatic tying tool is characterized by further comprising a material pushing rod which is mounted on the frame or the housing of the automated tying tool, the material pushing rod is adapted to push the tie located on the center plane of the automated tying tool to the slider to be pre-positioned, and the slider is adapted to drive the tie to slide from the pre-positioning position to a binding operation position.
An apparatus for sealing a pouch case of a pouch-type secondary battery, the apparatus comprising: an upper compression jig to apply pressure to the sealing portion of the pouch case in a downward direction; and a lower compression jig to apply pressure to the sealing portion of the pouch case in an upward direction, wherein at least one of the upper compression jig and the lower compression jig applies the pressure to the pouch case at different depths at an inner side end and an outer side end characterized in that at least one of the upper compression jig and the lower compression jig tilts in contact with the pouch case; and the tilting is performed in a manner of applying a higher pressure to the pouch case at an outside end of at least one of the upper compression jig and the lower compression jig. an upper compression jig to apply pressure to the sealing portion of the pouch case in a downward direction; and a lower compression jig to apply pressure to the sealing portion of the pouch case in an upward direction, wherein at least one of the upper compression jig and the lower compression jig applies the pressure to the pouch case at different depths at an inner side end and an outer side end characterized in that at least one of the upper compression jig and the lower compression jig tilts in contact with the pouch case; and the tilting is performed in a manner of applying a higher pressure to the pouch case at an outside end of at least one of the upper compression jig and the lower compression jig.
A rechargeable lithium battery comprising: a positive electrode comprising a positive active material; a negative electrode comprising a negative active material wherein the negative active material comprises a Si-based compound and a carbon material; and an electrolyte solution comprising: a non-aqueous organic solvent including alkyl acetate; a lithium salt; and an electrolyte additive including a sultone-based compound, wherein the sultone-based compound is included in an amount of 0.1 to 5 wt.% based on the total weight of the electrolyte solution, characterized in that the Si-based compound and the carbon material are included in a weight ratio ranging from 1:99 to 10:90. a positive electrode comprising a positive active material; a negative electrode comprising a negative active material wherein the negative active material comprises a Si-based compound and a carbon material; and an electrolyte solution comprising: a non-aqueous organic solvent including alkyl acetate; a lithium salt; and an electrolyte additive including a sultone-based compound, wherein the sultone-based compound is included in an amount of 0.1 to 5 wt.% based on the total weight of the electrolyte solution, characterized in that the Si-based compound and the carbon material are included in a weight ratio ranging from 1:99 to 10:90.