A dual mode sample manager for a liquid chromatography system, comprising: a sample needle to acquire a sample from a sample source for injection into a chromatography system flow; a sample loop having a fixed volume; a metering pump controllable to draw or dispense a volume of a liquid: a needle seat configured to fluidically couple the sample needle in a first fluidic path; a first valve having a plurality of first valve ports (50-N) and being configurable in a first valve state wherein one of the first valve ports is configured in fluidic communication with at least one of the other first valve ports and configurable in a second valve state wherein the one of the first valve ports is configured in fluidic communication with a different one of the other first valve ports, the first valve being in fluidic communication with the metering pump and configured to receive a wash solvent and a chromatography system flow, and to deliver the received chromatography system flow; and a second valve having a plurality of second valve ports (52-N) and being configurable in the first valve state wherein one of the second valve ports is configured in fluidic communication with at least one of the other second valve ports and configurable in the second valve state wherein the one of the second valve ports is configured in fluidic communication with a different one of the other second valve ports, the second valve having a first pair of second valve ports coupled to ends of the first fluidic path and having a second pair of second valve ports coupled to ends of a second fluidic path defined by the fixed sample loop, wherein the first valve and second valve are configurable so that in one mode the sample acquired and stored in the first fluidic path is injected into the chromatography system flow and in another mode the sample acquired through the sample needle and stored in the second fluidic path is injected into the chromatography system flow. a sample needle to acquire a sample from a sample source for injection into a chromatography system flow; a sample loop having a fixed volume; a metering pump controllable to draw or dispense a volume of a liquid: a needle seat configured to fluidically couple the sample needle in a first fluidic path; a first valve having a plurality of first valve ports (50-N) and being configurable in a first valve state wherein one of the first valve ports is configured in fluidic communication with at least one of the other first valve ports and configurable in a second valve state wherein the one of the first valve ports is configured in fluidic communication with a different one of the other first valve ports, the first valve being in fluidic communication with the metering pump and configured to receive a wash solvent and a chromatography system flow, and to deliver the received chromatography system flow; and a second valve having a plurality of second valve ports (52-N) and being configurable in the first valve state wherein one of the second valve ports is configured in fluidic communication with at least one of the other second valve ports and configurable in the second valve state wherein the one of the second valve ports is configured in fluidic communication with a different one of the other second valve ports, the second valve having a first pair of second valve ports coupled to ends of the first fluidic path and having a second pair of second valve ports coupled to ends of a second fluidic path defined by the fixed sample loop, wherein the first valve and second valve are configurable so that in one mode the sample acquired and stored in the first fluidic path is injected into the chromatography system flow and in another mode the sample acquired through the sample needle and stored in the second fluidic path is injected into the chromatography system flow.