A compound for use in a method for the treatment of cancer which is selected from: 5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2,3-dihydroxy-propoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-bromo-2-fluorophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide; 5-(4-bromo-2-fluoro-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-bromo-2-fluoro-phenylamino)-8-fluoro-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2,3-dihydroxy-propoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(2-fluoro-methanesulfanyl-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-cyclopropyl-2-fluoro-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; - N -(2,3-dihydroxypropoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; N -ethoxy-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; N -(cyclopropylmethoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; 5-(2-fluoro-4-iodophenylamino)- N -methylimidazo[1,5- a]pyrazine-6-carboxamide; 5-(4-bromo-2-fluorophenylamino)- N -(2-hydroxy-ethoxy)imidazo[1,5- a]pyrazine-6-carboxamide; -5-(4-bromo-2-fluorophenylamino)- N -(2-hydroxy-propoxy)imidazo[1,5- a]pyrazine-6-carboxamide; -5-(4-bromo-2-fluorophenylamino)- N -(2,3-dihydroxy-propoxy)imidazo[1,5- a]pyrazine-6-carboxamide; and, 5-(4-bromo-2-fluorophenylamino)- N -(cyclopropyl-methoxy)imidazo[1,5- a]pyrazine-6-carboxamide; or a pharmaceutically acceptable salt thereof; the method comprising administering the compound in combination with gemcitabine or a taxoid. 5-(2-fluoro-4-iodophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2,3-dihydroxy-propoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-bromo-2-fluorophenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxyethoxy)-amide; 5-(4-bromo-2-fluoro-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-bromo-2-fluoro-phenylamino)-8-fluoro-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2,3-dihydroxy-propoxy)-amide; 8-fluoro-5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(2-fluoro-methanesulfanyl-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; 5-(2-fluoro-4-iodo-phenylamino)-imidazo[1,5-a]pyrazine-6-carboxylic acid ( -2-hydroxy-propoxy)-amide; 5-(4-cyclopropyl-2-fluoro-phenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid (2-hydroxy-ethoxy)-amide; - N -(2,3-dihydroxypropoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; N -ethoxy-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; N -(cyclopropylmethoxy)-5-(2-fluoro-4-iodophenylamino)imidazo[1,5- a]pyrazine-6-carboxamide; 5-(2-fluoro-4-iodophenylamino)- N -methylimidazo[1,5- a]pyrazine-6-carboxamide; 5-(4-bromo-2-fluorophenylamino)- N -(2-hydroxy-ethoxy)imidazo[1,5- a]pyrazine-6-carboxamide; -5-(4-bromo-2-fluorophenylamino)- N -(2-hydroxy-propoxy)imidazo[1,5- a]pyrazine-6-carboxamide; -5-(4-bromo-2-fluorophenylamino)- N -(2,3-dihydroxy-propoxy)imidazo[1,5- a]pyrazine-6-carboxamide; and, 5-(4-bromo-2-fluorophenylamino)- N -(cyclopropyl-methoxy)imidazo[1,5- a]pyrazine-6-carboxamide; or a pharmaceutically acceptable salt thereof; the method comprising administering the compound in combination with gemcitabine or a taxoid.