mhurhangee/ep-ind-claims huggingface dataset:
An autotaxin inhibitor for use in a method for treating or preventing: pruritus, an inflammatory disease or condition, an autoimmune disease or condition, elevated intraocular pressure, or combinations thereof in a mammal, wherein the inflammatory disease or condition, or the autoimmune disease or condition is: psoriasis, rheumatoid arthritis, vasculitis, inflammatory bowel disease, dermatitis, inflammatory muscle disease, allergic rhinitis, vaginitis, interstitial cystitis, scleroderma, eczema, lupus erythematosus, dermatomyositis, Sjögren's syndrome, thyroiditis, myasthenia gravis, autoimmune hemolytic anemia, multiple sclerosis, cystic fibrosis, chronic relapsing hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, allergic conjunctivitis or atopic dermatitis; wherein the autotaxin inhibitor has the following structure: or or a pharmaceutically acceptable salt, or solvate thereof. pruritus, an inflammatory disease or condition, an autoimmune disease or condition, elevated intraocular pressure, or combinations thereof in a mammal, wherein the inflammatory disease or condition, or the autoimmune disease or condition is: psoriasis, rheumatoid arthritis, vasculitis, inflammatory bowel disease, dermatitis, inflammatory muscle disease, allergic rhinitis, vaginitis, interstitial cystitis, scleroderma, eczema, lupus erythematosus, dermatomyositis, Sjögren's syndrome, thyroiditis, myasthenia gravis, autoimmune hemolytic anemia, multiple sclerosis, cystic fibrosis, chronic relapsing hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, allergic conjunctivitis or atopic dermatitis; wherein the autotaxin inhibitor has the following structure: or
An enclosure for an electronic device comprising: a housing including a bottom wall and at least one sidewall extending from the bottom wall to define a cavity, the at least one sidewall having a distal end portion; and a cover attached to the housing, the cover including: a top wall and at least one outer wall extending from the top wall to define a chamber, the at least one outer wall defining an aperture that is in communication with the chamber; a ridge extending from the top wall and into the chamber; and a groove defined between the at least one outer wall and the ridge, wherein at least a portion of the housing is received within the chamber such that the distal end portion of the at least one sidewall is aligned with and positioned within the groove, characterized in that an interior surface of the at least one outer wall includes a step, the step positioned opposite and adjacent the ridge such that the step and the ridge define the groove, wherein the step includes a plurality of segments distributed along a length of the outer wall with adjacent segments of the plurality of segments separated by a gap. a housing including a bottom wall and at least one sidewall extending from the bottom wall to define a cavity, the at least one sidewall having a distal end portion; and a cover attached to the housing, the cover including: a top wall and at least one outer wall extending from the top wall to define a chamber, the at least one outer wall defining an aperture that is in communication with the chamber; a ridge extending from the top wall and into the chamber; and a groove defined between the at least one outer wall and the ridge, wherein at least a portion of the housing is received within the chamber such that the distal end portion of the at least one sidewall is aligned with and positioned within the groove, characterized in that an interior surface of the at least one outer wall includes a step, the step positioned opposite and adjacent the ridge such that the step and the ridge define the groove, wherein the step includes a plurality of segments distributed along a length of the outer wall with adjacent segments of the plurality of segments separated by a gap. a top wall and at least one outer wall extending from the top wall to define a chamber, the at least one outer wall defining an aperture that is in communication with the chamber; a ridge extending from the top wall and into the chamber; and a groove defined between the at least one outer wall and the ridge, wherein at least a portion of the housing is received within the chamber such that the distal end portion of the at least one sidewall is aligned with and positioned within the groove, characterized in that an interior surface of the at least one outer wall includes a step, the step positioned opposite and adjacent the ridge such that the step and the ridge define the groove, wherein the step includes a plurality of segments distributed along a length of the outer wall with adjacent segments of the plurality of segments separated by a gap.
Hydraulic module for a hydraulic anti-lock system for a two-wheeled vehicle, the hydraulic module comprising: a first hydraulic port for the connection of the hydraulic module to a hydraulic line to a brake actuating device; a second hydraulic port for the connection of the hydraulic module to a hydraulic line to a wheel brake; an inlet valve for the connection and separation of the first hydraulic port to and from the second hydraulic port; an outlet valve for connecting and separating a pressure accumulator to and from the second hydraulic port; a housing in which the inlet valve and the outlet valve are accommodated and which provides the first hydraulic port and the second hydraulic port; characterized by a holder for accommodating the housing, which cover has a clamp which is designed to fasten the hydraulic module to a frame element of the two-wheeled vehicle; and wherein the pressure accumulator is arranged in the housing, and the housing comprises a pressure accumulator opening for accommodating the pressure accumulator, which pressure accumulator opening runs parallel to an axis of the inlet valve and/or of the outlet valve; wherein the holder has a side wall which at least partially surrounds the housing and has a base wall on which the housing, at the side of the pressure accumulator, is seated. a first hydraulic port for the connection of the hydraulic module to a hydraulic line to a brake actuating device; a second hydraulic port for the connection of the hydraulic module to a hydraulic line to a wheel brake; an inlet valve for the connection and separation of the first hydraulic port to and from the second hydraulic port; an outlet valve for connecting and separating a pressure accumulator to and from the second hydraulic port; a housing in which the inlet valve and the outlet valve are accommodated and which provides the first hydraulic port and the second hydraulic port; characterized by a holder for accommodating the housing, which cover has a clamp which is designed to fasten the hydraulic module to a frame element of the two-wheeled vehicle; and wherein the pressure accumulator is arranged in the housing, and the housing comprises a pressure accumulator opening for accommodating the pressure accumulator, which pressure accumulator opening runs parallel to an axis of the inlet valve and/or of the outlet valve; wherein the holder has a side wall which at least partially surrounds the housing and has a base wall on which the housing, at the side of the pressure accumulator, is seated.
An article useful as forming and cutting tool comprising: (a) an upper die having: (i) an upper pressure pad mounted to a support surface of the upper die, wherein the upper pressure pad includes an upper shearing edge located at least partially about an inner perimeter of the upper pressure pad; (ii) an upper mold mounted to the support surface of the upper die and disposed within a recess of the upper pressure pad; (b) a lower die opposing the upper die having: (i) a lower pressure pad mounted to a support surface of the lower die; (ii) a lower mold mounted to the support surface of the lower die and disposed within a recess of the lower pressure pad, wherein the lower mold includes a lower shearing edge located at least partially about an outer perimeter of the lower mold; and wherein the upper die is adapted to come into contact with the lower die such that the upper pressure pad applies pressure to the lower pressure pad and the upper mold applies pressure to the lower mold to form a composite structure; characterized in that the upper die is adapted to contact the lower die so that the upper shearing edge bypasses the lower shearing edge to form a non-planar cut in a portion of the composite structure, wherein a portion of the upper shearing edge and a portion of the lower shearing edge are non-planar and are curved, angled or both relative to a transverse plane of the article, a longitudinal plane of the article, or both, and are adapted to form the non-planar cut. (a) an upper die having: (i) an upper pressure pad mounted to a support surface of the upper die, wherein the upper pressure pad includes an upper shearing edge located at least partially about an inner perimeter of the upper pressure pad; (ii) an upper mold mounted to the support surface of the upper die and disposed within a recess of the upper pressure pad; (i) an upper pressure pad mounted to a support surface of the upper die, wherein the upper pressure pad includes an upper shearing edge located at least partially about an inner perimeter of the upper pressure pad; (ii) an upper mold mounted to the support surface of the upper die and disposed within a recess of the upper pressure pad; (b) a lower die opposing the upper die having: (i) a lower pressure pad mounted to a support surface of the lower die; (ii) a lower mold mounted to the support surface of the lower die and disposed within a recess of the lower pressure pad, wherein the lower mold includes a lower shearing edge located at least partially about an outer perimeter of the lower mold; and (i) a lower pressure pad mounted to a support surface of the lower die; (ii) a lower mold mounted to the support surface of the lower die and disposed within a recess of the lower pressure pad, wherein the lower mold includes a lower shearing edge located at least partially about an outer perimeter of the lower mold; and
An image capturing apparatus comprising: an image capturing unit for capturing a first image and a second image; an image generator for generating, from the first image, a reduced image whose number of pixels is reduced compared to the first image; a memory for prestoring, for each of a plurality of different camera rotation angles, characteristic data of face areas of images of a subject captured at the respective angle, in correspondence with the respective angles as comparison standards, said plurality of camera rotation angles comprising a rotation angle of 0 degrees representing a generally horizontally oriented image capture angle of view and rotation angles of -90 and +90 degrees representing a generally vertically oriented image capture angle of view, said characteristic data representing a configuration of a face captured within the face area at the respective angle; a face area detector for detecting a face area in the reduced image by comparing the reduced image to the prestored characteristic data for each of the plurality of different angles and for storing information on the detected face area in a detection result storage area, said information indicating an image capture angle of the detected face area; and a face area detection controller for controlling the face area detector to detect a face area in the second image by comparing the second image only to the prestored characteristic data that corresponds to the image capture angle indicated by the information stored in the detection result storage area. an image capturing unit for capturing a first image and a second image; an image generator for generating, from the first image, a reduced image whose number of pixels is reduced compared to the first image; a memory for prestoring, for each of a plurality of different camera rotation angles, characteristic data of face areas of images of a subject captured at the respective angle, in correspondence with the respective angles as comparison standards, said plurality of camera rotation angles comprising a rotation angle of 0 degrees representing a generally horizontally oriented image capture angle of view and rotation angles of -90 and +90 degrees representing a generally vertically oriented image capture angle of view, said characteristic data representing a configuration of a face captured within the face area at the respective angle; a face area detector for detecting a face area in the reduced image by comparing the reduced image to the prestored characteristic data for each of the plurality of different angles and for storing information on the detected face area in a detection result storage area, said information indicating an image capture angle of the detected face area; and a face area detection controller for controlling the face area detector to detect a face area in the second image by comparing the second image only to the prestored characteristic data that corresponds to the image capture angle indicated by the information stored in the detection result storage area.
An amphoteric fluorescent substance capable of binding to a biomaterial, the substance comprising at least one of compounds represented by a following Structural Formula 1: wherein in the Structural Formula 1, L i s - n -, L1 is -NH-CH 2 -(CH 2 -O-CH 2) m -CH 2 -C(=O)-, L2 is one of azide, acetylene, maleimide, biotin, hydrizide, R 3 -(C(=O) 2 -NH-NH 2, and -R 4 -(S(=O) 2 -NH-NH 2, each of R 1, R 2, R 3, and R 4 is C1-6 divalent aliphatic hydrocarbon, C1-6 alkylene or divalent aromatic hydrocarbon, or a derivative thereof, n is 0 or 1, and m is an integer of 0 to 4. L i s - n -, L1 is -NH-CH 2 -(CH 2 -O-CH 2) m -CH 2 -C(=O)-, L2 is one of azide, acetylene, maleimide, biotin, hydrizide, R 3 -(C(=O) 2 -NH-NH 2, and -R 4 -(S(=O) 2 -NH-NH 2, each of R 1, R 2, R 3, and R 4 is C1-6 divalent aliphatic hydrocarbon, C1-6 alkylene or divalent aromatic hydrocarbon, or a derivative thereof, n is 0 or 1, and m is an integer of 0 to 4.
A surgical instrument comprising: a balloon dissector assembly, including: a balloon dissector having a dissector housing; a dissector tube extending distally from the dissector housing and comprising an inflation port at a proximal end, and a dissection balloon mounted on a distal end of the dissector tube, and a balloon tip cannula assembly, including: a cannula having a cannula housing and a cannula tube extending distally from the cannula housing, the cannula housing having a balloon anchor at a distal end of the cannula tube, wherein the dissector tube is received within the cannula tube when the balloon dissector is engaged with the cannula, characterized in that the surgical instrument further comprises an adapter assembly configured for attachment to the proximal end of the dissector tube, the adapter assembly including a central opening, the central opening being adapted to receive instrumentation therethrough, the adapter assembly including a removable shroud dimensioned and configured to surround the proximal end of the dissector tube and an end cap having a latching adapter attached thereto, the latching adapter configured for engagement with the shroud and configured for engagement with the cannula housing when the shroud is removed. a balloon dissector assembly, including: a balloon dissector having a dissector housing; a dissector tube extending distally from the dissector housing and comprising an inflation port at a proximal end, and a dissection balloon mounted on a distal end of the dissector tube, and a balloon dissector having a dissector housing; a dissector tube extending distally from the dissector housing and comprising an inflation port at a proximal end, and a dissection balloon mounted on a distal end of the dissector tube, and a balloon tip cannula assembly, including: a cannula having a cannula housing and a cannula tube extending distally from the cannula housing, the cannula housing having a balloon anchor at a distal end of the cannula tube, wherein the dissector tube is received within the cannula tube when the balloon dissector is engaged with the cannula, characterized in that the surgical instrument further comprises an adapter assembly configured for attachment to the proximal end of the dissector tube, the adapter assembly including a central opening, the central opening being adapted to receive instrumentation therethrough, the adapter assembly including a removable shroud dimensioned and configured to surround the proximal end of the dissector tube and an end cap having a latching adapter attached thereto, the latching adapter configured for engagement with the shroud and configured for engagement with the cannula housing when the shroud is removed.
Method of operating a base station of a cellular communications network, wherein time and frequency resources are used for data transmission, wherein a first scheduling granularity is used for scheduling first resources associated with a first frequency range, and wherein a second scheduling granularity, which is different from said first scheduling granularity, is used for scheduling second resources associated with a second frequency range, wherein said first and second scheduling granularities are used within respective time intervals (ti1, ti2) which at least partly overlap each other.
Clamping gap nut, having a basic body in the form of a circumferentially open ring which has an outer casing wall, an inner casing wall with an inside diameter and two gap walls (15a, 15b) which are spaced apart from one another, point towards one another and delimit a gap of the circumferentially open ring and which are adjustable with respect to one another by means of a tension device, characterized in that the tension device has at least one traction means which is laid flexibly around at least one circumferential portion, bridging the gap, of the basic body.
Creping doctor comprising a blade-like main part composed of metal, in particular composed of steel or stainless steel, having a working edge which can be placed against a drying cylinder and which is adjoined by an end face with a counterpart edge, wherein notches are incorporated into the end face and are arranged at distances from one another, characterized in that a wear protection layer is provided between the working edge and that wall of the main body which faces towards the drying cylinder, and in that the notches are incorporated at least into the wear protection layer.
A packaging for filling materials, in particular a bag or a pouch made of a plastic film, with a packaging wall enclosing the filling material, which packaging wall is formed by means of at least one front wall and one rear wall (2, 3, 22, 23), wherein the front and rear walls are connected to one another in the base region (5, 25) by means of a standing base (4, 24) that is formed from at least two inner layers of an in-fold of a tubular web section folded at least on one side in the longitudinal direction, wherein the front and rear walls (2, 3, 22, 23) each have a fold-over (7, 8, 27, 28) in the top region (6, 26) of the packaging, wherein the upper wall section of one of the walls (2, 23) is folded over on itself so as to form a multi-layer region (16, 40), wherein the multi-layer region is formed by laying surface area sections of the inner wall face of the one wall on top of one another, and wherein at least one joining seam (9, 29) is provided, by means of which certain layers of the walls (2, 3, 22, 23) at least partially closing the packaging are connected to one another, characterized in that the upper wall section of the other wall (3, 22) is folded with its inner wall face onto the multi-layer region (16, 40) for forming an overlap region (17, 41) and that the joining seam (9, 29) is provided in the overlap region (17, 41).
A device (24, 90) suitable for delivery of a fluid composition to an eye, comprising: a hollow needle with abore having a proximal end and a distal end, said needle; and a solid separator (50, 92) having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said needle distal end, and further configured to create separation when inserted into layers of the eye below said sclera. characterized in that the device includes a body assembly comprising a separator assembly-accepting void connected by a communication passage with said bore of said hollow needle and an injector assembly-accepting void in fluid communication with said bore of said hollow needle, a separator assembly comprising said separator (50, 92) and an injector assembly, wherein the device is configured, when said separator assembly is located in said separator assembly-accepting void and said injector assembly is located in said injector assembly-accepting void, to allow said separator to protrude from said distal end of said needle and characterized in that said solid separator is configured to move inside the bore of the hollow needle allowing the distal tip of the separator to protrude from the distal end of the needle. a hollow needle with abore having a proximal end and a distal end, said needle; and a solid separator (50, 92) having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said needle distal end, and further configured to create separation when inserted into layers of the eye below said sclera. characterized in that the device includes a body assembly comprising a separator assembly-accepting void connected by a communication passage with said bore of said hollow needle and an injector assembly-accepting void in fluid communication with said bore of said hollow needle, a separator assembly comprising said separator (50, 92) and an injector assembly, wherein the device is configured, when said separator assembly is located in said separator assembly-accepting void and said injector assembly is located in said injector assembly-accepting void, to allow said separator to protrude from said distal end of said needle and characterized in that said solid separator is configured to move inside the bore of the hollow needle allowing the distal tip of the separator to protrude from the distal end of the needle.
A catheter containing a locking solution represented by an antimicrobial composition, the antimicrobial composition consisting of: at least one poloxamer; at least 10 weight percent of at least one alcohol on a basis of total weight of the antimicrobial composition; 0.01 wt.% to 10 wt.%, based on the weight of the antimicrobial composition, of at least one biocidal agent that is not an alcohol; and optionally, an additive selected from the group consisting of an anticoagulant, saline, water, and combinations thereof. at least one poloxamer; at least 10 weight percent of at least one alcohol on a basis of total weight of the antimicrobial composition; 0.01 wt.% to 10 wt.%, based on the weight of the antimicrobial composition, of at least one biocidal agent that is not an alcohol; and optionally, an additive selected from the group consisting of an anticoagulant, saline, water, and combinations thereof.