Stimulation therapy system, comprising: - a stimulation device such as an implantable pulse generator connected to one or more electrodes placed on or close to a nerve of the autonomic nervous system; - an external communication device, capable of communicating with the pulse generator; - at least one sensor for detecting physiological and/or physical signals and units for processing the signals, which are capable of delivering at least one current physiological/physical level ( PVLcourant); - means for controlling the stimulation device according to a set of stimulation parameters; and - means for adapting the state transition model of a physiological or physical level, characterized in that it comprises means for regulating the stimulation, these means: - being multiresolution means that are capable of operating on the basis of multiple variables having different respective time and/or space resolutions; - including a plurality of control modules (227a... 227n), each comprising: • a state transition model comprising a transition matrix (Tk) and a connection matrix (Ck), making it possible to estimate the optimal stimulation parameters (Pi,k) so as to bring the current physiological/physical level ( PVLcourant) to a given setpoint level ( PVLcible); • the states (Si,k) being characterized by a set of values of the stimulation parameters (Pi,k) and at least one expected physiological/physical response (RSi,k) when applying a stimulation; • a state transition control device determining, in an organized manner, the transitions from a current state (Si,k) to a new state (Sj,k), causing a corresponding change in the set of values of the respective stimulation parameters; and • a parameter-merging module making it possible to define the definitive stimulation parameters according to the parameters estimated by each of the control modules. - a stimulation device such as an implantable pulse generator connected to one or more electrodes placed on or close to a nerve of the autonomic nervous system; - an external communication device, capable of communicating with the pulse generator; - at least one sensor for detecting physiological and/or physical signals and units for processing the signals, which are capable of delivering at least one current physiological/physical level ( PVLcourant); - means for controlling the stimulation device according to a set of stimulation parameters; and - means for adapting the state transition model of a physiological or physical level, characterized in that it comprises means for regulating the stimulation, these means: - being multiresolution means that are capable of operating on the basis of multiple variables having different respective time and/or space resolutions; - including a plurality of control modules (227a... 227n), each comprising: • a state transition model comprising a transition matrix (Tk) and a connection matrix (Ck), making it possible to estimate the optimal stimulation parameters (Pi,k) so as to bring the current physiological/physical level ( PVLcourant) to a given setpoint level ( PVLcible); • the states (Si,k) being characterized by a set of values of the stimulation parameters (Pi,k) and at least one expected physiological/physical response (RSi,k) when applying a stimulation; • a state transition control device determining, in an organized manner, the transitions from a current state (Si,k) to a new state (Sj,k), causing a corresponding change in the set of values of the respective stimulation parameters; and • a parameter-merging module making it possible to define the definitive stimulation parameters according to the parameters estimated by each of the control modules. - being multiresolution means that are capable of operating on the basis of multiple variables having different respective time and/or space resolutions; - including a plurality of control modules (227a... 227n), each comprising: • a state transition model comprising a transition matrix (Tk) and a connection matrix (Ck), making it possible to estimate the optimal stimulation parameters (Pi,k) so as to bring the current physiological/physical level ( PVLcourant) to a given setpoint level ( PVLcible); • the states (Si,k) being characterized by a set of values of the stimulation parameters (Pi,k) and at least one expected physiological/physical response (RSi,k) when applying a stimulation; • a state transition control device determining, in an organized manner, the transitions from a current state (Si,k) to a new state (Sj,k), causing a corresponding change in the set of values of the respective stimulation parameters; and • a parameter-merging module making it possible to define the definitive stimulation parameters according to the parameters estimated by each of the control modules. • a state transition model comprising a transition matrix (Tk) and a connection matrix (Ck), making it possible to estimate the optimal stimulation parameters (Pi,k) so as to bring the current physiological/physical level ( PVLcourant) to a given setpoint level ( PVLcible); • the states (Si,k) being characterized by a set of values of the stimulation parameters (Pi,k) and at least one expected physiological/physical response (RSi,k) when applying a stimulation; • a state transition control device determining, in an organized manner, the transitions from a current state (Si,k) to a new state (Sj,k), causing a corresponding change in the set of values of the respective stimulation parameters; and • a parameter-merging module making it possible to define the definitive stimulation parameters according to the parameters estimated by each of the control modules.