A method for selecting a treatment for a subject having or suspected of having cancer, the method comprising: (a) measuring the level of dimerization of at least two receptor tyrosine kinases (RTKs), wherein measuring comprises: (i) incubating a cellular extract with one or a plurality of dilution series of capture antibodies to form a plurality of captured RTK analytes, wherein the cellular extract is isolated from a subject having cancer after administration of an anticancer drug or wherein the cellular extract is contacted with an anticancer drug; (ii) incubating the plurality of captured analytes with detection antibodies comprising a first or a plurality of first activation state-independent antibodies and a second or a plurality of second activation state-independent antibodies specific for a first member and a second member, respectively, of a dimerized pair of analytes to form a plurality of detectable captured dimerized analytes, wherein the first activation state-independent antibodies are labeled with a facilitating moiety, the second activation state-independent antibodies are labeled with a first member of a signal amplification pair, and the facilitating moiety generates an oxidizing agent which channels to and reacts with the first member of the signal amplification pair; (iii) incubating the plurality of detectable captured dimerized analytes with a second member of the signal amplification pair to generate an amplified signal; and (iv) detecting the amplified signal generated from the first and second members of the signal amplification pair; and (b) selecting an anticancer drug by comparing the dimerization of at least two RTKs to a reference dimerization profile of the same two RTK wherein the reference dimerization profile is generated in the absence of the anticancer drug. (a) measuring the level of dimerization of at least two receptor tyrosine kinases (RTKs), wherein measuring comprises: (i) incubating a cellular extract with one or a plurality of dilution series of capture antibodies to form a plurality of captured RTK analytes, wherein the cellular extract is isolated from a subject having cancer after administration of an anticancer drug or wherein the cellular extract is contacted with an anticancer drug; (ii) incubating the plurality of captured analytes with detection antibodies comprising a first or a plurality of first activation state-independent antibodies and a second or a plurality of second activation state-independent antibodies specific for a first member and a second member, respectively, of a dimerized pair of analytes to form a plurality of detectable captured dimerized analytes, wherein the first activation state-independent antibodies are labeled with a facilitating moiety, the second activation state-independent antibodies are labeled with a first member of a signal amplification pair, and the facilitating moiety generates an oxidizing agent which channels to and reacts with the first member of the signal amplification pair; (iii) incubating the plurality of detectable captured dimerized analytes with a second member of the signal amplification pair to generate an amplified signal; and (iv) detecting the amplified signal generated from the first and second members of the signal amplification pair; and (i) incubating a cellular extract with one or a plurality of dilution series of capture antibodies to form a plurality of captured RTK analytes, wherein the cellular extract is isolated from a subject having cancer after administration of an anticancer drug or wherein the cellular extract is contacted with an anticancer drug; (ii) incubating the plurality of captured analytes with detection antibodies comprising a first or a plurality of first activation state-independent antibodies and a second or a plurality of second activation state-independent antibodies specific for a first member and a second member, respectively, of a dimerized pair of analytes to form a plurality of detectable captured dimerized analytes, wherein the first activation state-independent antibodies are labeled with a facilitating moiety, the second activation state-independent antibodies are labeled with a first member of a signal amplification pair, and the facilitating moiety generates an oxidizing agent which channels to and reacts with the first member of the signal amplification pair; (iii) incubating the plurality of detectable captured dimerized analytes with a second member of the signal amplification pair to generate an amplified signal; and (iv) detecting the amplified signal generated from the first and second members of the signal amplification pair; and (b) selecting an anticancer drug by comparing the dimerization of at least two RTKs to a reference dimerization profile of the same two RTK wherein the reference dimerization profile is generated in the absence of the anticancer drug.