mhurhangee/ep-ind-claims huggingface dataset:
An oxygenator unit adapted for the use in an extracorporeal blood treatment device, comprising an oxygenator and a supply line for conducting a gas, the supply line being provided at a gas inlet port of the oxygenator and connectable to a source of a pressurized gas containing oxygen, wherein the oxygenator unit further comprises a pressure relief valve which is provided in the supply line upstream of the oxygenator, the pressure relief valve being configured to release pressure exceeding a predetermined pressure value from the supply line, thereby preventing a critical overpressure in the oxygenator, characterized in that the pressure relief valve is a 3/2 switching valve provided with a spring, or provided with a piezo element and a corresponding control unit, wherein, when the supply line is exposed to pressure below the predetermined pressure value, the spring or the piezo element holds the pressure relief valve in the open position, and, when the pressure exceeds the predetermined pressure value, the pressure relief valve is switched to the closed position and the pressure of the source is released via the pressure relief valve.
An iron comprising a soleplate, a heating element (6, 28) thermally coupled with the soleplate, a thermostat unit (12, 29) configured for controlling operation of the heating element (6, 28), the thermostat unit (12, 29) being configured for alternatingly effecting heating phases and non-heating phases of the heating element (6, 28), a switch element (14, 31) adapted for switching a power supply of the heating element (6, 28), a control unit (15, 32) adapted for controlling a switching operation of the switch element (14, 31), wherein the control unit (15, 32) is configured for assigning a respective time pattern defining one or more power interruption intervals (21, 41) to at least one selected heating phase of said heating phases, with the switch element (14, 31) being configured for interrupting power supply of the heating element (6, 28) during the one or more power interruption intervals (21, 41) in accordance with the respective time pattern; characterised in that the iron further comprises an auto switch-off unit configured for switching off the power supply of the heating element (6, 28) in case the iron is not moved or gripped during a predetermined period of time; with the control unit (15, 32) and the switch element (14, 31) being part of the auto switch-off unit; wherein the switch element (14, 31) is connected in series with the thermostat unit (12, 29); wherein the auto switch-off unit further comprises a sensor connected to the control unit, such that the sensor signals generated by the sensor are evaluated by the control unit, and wherein the thermostat unit (12,29) is a mechanical thermostat.
A method for heat treating a superalloy component, comprising: heating a superalloy component to a first temperature; cooling the superalloy component from the first temperature to a second temperature at a first pressure in a furnace; and cooling the superalloy component from the second temperature to a final temperature at second pressure, wherein the second pressure is higher than the first pressure, without removing the superalloy component from the furnace, wherein the first cooling step has a first rate of cooling and the second cooling step has a second rate of cooling, and wherein the second rate of cooling is greater than the first rate of cooling. heating a superalloy component to a first temperature; cooling the superalloy component from the first temperature to a second temperature at a first pressure in a furnace; and cooling the superalloy component from the second temperature to a final temperature at second pressure, wherein the second pressure is higher than the first pressure, without removing the superalloy component from the furnace, wherein the first cooling step has a first rate of cooling and the second cooling step has a second rate of cooling, and wherein the second rate of cooling is greater than the first rate of cooling.
An aircraft landing gear, comprising: a shock strut including a rod with a first end slidably disposed within a cylinder; a beam rotatably coupled to a second end of the rod, the beam being configured to have a forward wheel and an aft wheel rotatably mounted thereto; and a link assembly, comprising: an upper link having a first end rotatably connected to the cylinder; and a lower link having a first end rotatably connected to the beam, a second end of the lower link being rotatably coupled to a second end of the upper link; and a limiter, characterised in that the limiter comprises a first stop associated with the upper link and a second stop associated with the lower link, the first stop engaging the second stop to limit rotation of the upper link relative to the lower link, wherein the limiter is selectively adjustable to provide a predetermined maximum distance between the first end of the upper link and the first end of the lower link. a shock strut including a rod with a first end slidably disposed within a cylinder; a beam rotatably coupled to a second end of the rod, the beam being configured to have a forward wheel and an aft wheel rotatably mounted thereto; and a link assembly, comprising: an upper link having a first end rotatably connected to the cylinder; and a lower link having a first end rotatably connected to the beam, a second end of the lower link being rotatably coupled to a second end of the upper link; and a limiter, characterised in that the limiter comprises a first stop associated with the upper link and a second stop associated with the lower link, the first stop engaging the second stop to limit rotation of the upper link relative to the lower link, wherein the limiter is selectively adjustable to provide a predetermined maximum distance between the first end of the upper link and the first end of the lower link.
A server, comprising: communication circuitry configured to communicate with a plurality of external terminals; a storage configured to store reference data of the plurality of external terminals; and a processor configured to, based on a request for hardware integrity verification of a second external terminal being received from a first external terminal through the communication circuitry, perform hardware integrity verification of a second external terminal using reference data of the second external terminal, wherein, based on the second external terminal accessing the first external terminal, the server is configured to receive, from the first external terminal, a transmission of the request for hardware integrity verification of the second external terminal, wherein, based the request for the hardware integrity verification being received, the processor is configured to control the communication circuitry to request transmission of data for the hardware integrity verification of the second external terminal to the second external terminal, not via the first external terminal, and, wherein, based on the data for the hardware integrity verification of the second external terminal being received from the second external terminal, not via the first external terminal, the processor is configured to perform the hardware integrity verification of the second external terminal by comparing the received data with the reference data of the second external terminal stored in the storage. communication circuitry configured to communicate with a plurality of external terminals; a storage configured to store reference data of the plurality of external terminals; and a processor configured to, based on a request for hardware integrity verification of a second external terminal being received from a first external terminal through the communication circuitry, perform hardware integrity verification of a second external terminal using reference data of the second external terminal, wherein, based on the second external terminal accessing the first external terminal, the server is configured to receive, from the first external terminal, a transmission of the request for hardware integrity verification of the second external terminal, wherein, based the request for the hardware integrity verification being received, the processor is configured to control the communication circuitry to request transmission of data for the hardware integrity verification of the second external terminal to the second external terminal, not via the first external terminal, and, wherein, based on the data for the hardware integrity verification of the second external terminal being received from the second external terminal, not via the first external terminal, the processor is configured to perform the hardware integrity verification of the second external terminal by comparing the received data with the reference data of the second external terminal stored in the storage.
A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer, the method comprising the following steps: a) at least one voltage application step, wherein in the voltage application step a direct current voltage and a radio frequency voltage are applied between two pairs of electrodes of at least one mass filter of the quadrupole mass analyzer, wherein the AC voltage has an amplitude V AC and the DC voltage has an applicable voltage V DC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage; b) at least one measurement step, wherein at least one transition of the analyte is determined with at least one detector of the quadrupole mass analyzer, characterized in that an amplitude ΔV DC of the supplementary AC voltage is ≤ V DC, max 2 b + 1, wherein V DC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board that provides the AC and/or the DC voltages to the electrodes of said at least one mass filter of the quadrupole mass analyzer, wherein the electronics board is configured for providing the AC and DC voltages to the electrodes of the mass filter, wherein the electronics board comprises at least one digital-to-analog converter. a) at least one voltage application step, wherein in the voltage application step a direct current voltage and a radio frequency voltage are applied between two pairs of electrodes of at least one mass filter of the quadrupole mass analyzer, wherein the AC voltage has an amplitude V AC and the DC voltage has an applicable voltage V DC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage; b) at least one measurement step, wherein at least one transition of the analyte is determined with at least one detector of the quadrupole mass analyzer, characterized in that an amplitude ΔV DC of the supplementary AC voltage is ≤ V DC, max 2 b + 1, wherein V DC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board that provides the AC and/or the DC voltages to the electrodes of said at least one mass filter of the quadrupole mass analyzer, wherein the electronics board is configured for providing the AC and DC voltages to the electrodes of the mass filter, wherein the electronics board comprises at least one digital-to-analog converter.
A FGF2-binding peptide of formula I: R 1 -Ala-X 1 -Pro-X 2 -Ala-R 2 wherein: X 1 is an amino acid selected between Arg and Lys; X 2 is an amino acid selected between Cys and Thr; R 1 is either absent or consists of the amino acid sequence selected from SEQ ID NO: 1 and SEQ ID NO: 3; R 2 is either absent or consists of the amino acid sequence selected from SEQ ID NO: 2 and SEQ ID NO: 4, with the following provisions: when R 1 is absent, also R 2 is absent; when R 1 is the amino acid sequence of SEQ ID NO: 1, R 2 is the amino acid sequence of SEQ ID NO: 2; when R 1 is the amino acid sequence of SEQ ID NO: 3, R 2 is an amino acid sequence selected between SEQ ID NO: 2 and SEQ ID NO: 4; or a pharmaceutically acceptable salt thereof. X 1 is an amino acid selected between Arg and Lys; X 2 is an amino acid selected between Cys and Thr; R 1 is either absent or consists of the amino acid sequence selected from SEQ ID NO: 1 and SEQ ID NO: 3; R 2 is either absent or consists of the amino acid sequence selected from SEQ ID NO: 2 and SEQ ID NO: 4, with the following provisions: when R 1 is absent, also R 2 is absent; when R 1 is the amino acid sequence of SEQ ID NO: 1, R 2 is the amino acid sequence of SEQ ID NO: 2; when R 1 is the amino acid sequence of SEQ ID NO: 3, R 2 is an amino acid sequence selected between SEQ ID NO: 2 and SEQ ID NO: 4; or a pharmaceutically acceptable salt thereof.
A fixture for being attached to an arm of a patient, comprising: an arm holder to be arranged adjacent an elbow of the patient and comprising an arm support and a belt for attaching the arm to the arm support; a wrist holder attached to the arm holder for supporting the wrist; and a link for attaching the arm holder to a fixture board intended to be arranged on a bed board for a patient, wherein the distance between the arm holder and the fixture board is adjustable. characterized in that said link comprises a first swivel joint arranged at said fixture board, a second swivel joint arranged at said arm holder and a link arm for connecting said first and second swivel joints. an arm holder to be arranged adjacent an elbow of the patient and comprising an arm support and a belt for attaching the arm to the arm support; a wrist holder attached to the arm holder for supporting the wrist; and a link for attaching the arm holder to a fixture board intended to be arranged on a bed board for a patient, wherein the distance between the arm holder and the fixture board is adjustable. characterized in that said link comprises a first swivel joint arranged at said fixture board, a second swivel joint arranged at said arm holder and a link arm for connecting said first and second swivel joints.
A method for prioritizing candidate neoantigens for a patient for the immunotherapeutic treatment of cancer comprising: identifying candidate neoantigens_using sequence data obtained from a patient's tumor sample; determining self-similarity of the candidate neoantigens to an equivalent parental wildtype peptide to determine a self-similarity score, wherein a lower self-similarity score indicates an increased likelihood of clinical utility for a candidate neoantigen; determining similarity of the candidate neoantigens to known antigens_to determine a known antigen similarity score, wherein a higher known antigen similarity score indicates an increased likelihood of clinical utility for a candidate neoantigen, wherein the known antigens are peptides associated with recurrent somatic mutations, and wherein the peptides are selected from at least two of the following, BRAF, KRAS, PIK3CA, NRAS, APC, TP53, FBXW7, EGFR, IDH1 and SMAD4; determining a level of expression of the candidate neoantigens; identifying a mutant allele frequency in exons encoding the candidate neoantigens; performing a multivariate analysis of the results of the determining steps and identifying step to rank the candidate neoantigens according to a likelihood of clinical significance, wherein one or more of the identifying, determining, or performing steps are performed using a computer comprising a processor coupled to a tangible, non-transient memory and an input/output device; preparing a report comprising the ranking of the candidate neoantigens; and sending the report to the output device, thereby prioritizing candidates neoantigens. identifying candidate neoantigens_using sequence data obtained from a patient's tumor sample; determining self-similarity of the candidate neoantigens to an equivalent parental wildtype peptide to determine a self-similarity score, wherein a lower self-similarity score indicates an increased likelihood of clinical utility for a candidate neoantigen; determining similarity of the candidate neoantigens to known antigens_to determine a known antigen similarity score, wherein a higher known antigen similarity score indicates an increased likelihood of clinical utility for a candidate neoantigen, wherein the known antigens are peptides associated with recurrent somatic mutations, and wherein the peptides are selected from at least two of the following, BRAF, KRAS, PIK3CA, NRAS, APC, TP53, FBXW7, EGFR, IDH1 and SMAD4; determining a level of expression of the candidate neoantigens; identifying a mutant allele frequency in exons encoding the candidate neoantigens; performing a multivariate analysis of the results of the determining steps and identifying step to rank the candidate neoantigens according to a likelihood of clinical significance, wherein one or more of the identifying, determining, or performing steps are performed using a computer comprising a processor coupled to a tangible, non-transient memory and an input/output device; preparing a report comprising the ranking of the candidate neoantigens; and sending the report to the output device,
A display device (1000, 1000a, 1000b, 1000c), comprising a substrate that includes a first display area and a second display area, wherein: the first display area includes a plurality of first pixel areas and regions between the first pixel areas, each of the plurality of first pixel areas including one or more first pixels, the second display area includes a plurality of second pixel areas and a light transmittance area, each of the plurality of second pixel areas including one or more second pixels, the light transmittance area has higher light transmittance than the second pixel area, the first display area and the second display area include a common electrode that transmits a constant common voltage, a thickness of the common electrode in the first display area is uniform, the common electrode in the second display area includes a plurality of patterned regions that correspond to a first light transmittance area in the light transmittance area, and the plurality of patterned regions and the plurality of second pixel areas are alternately arranged along a first direction in the second display area, characterised in that, a thickness of the common electrode in the patterned regions is smaller than a thickness of the common electrode in a region other than the patterned regions, and is greater than zero. the first display area includes a plurality of first pixel areas and regions between the first pixel areas, each of the plurality of first pixel areas including one or more first pixels, the second display area includes a plurality of second pixel areas and a light transmittance area, each of the plurality of second pixel areas including one or more second pixels, the light transmittance area has higher light transmittance than the second pixel area, the first display area and the second display area include a common electrode that transmits a constant common voltage, a thickness of the common electrode in the first display area is uniform, the common electrode in the second display area includes a plurality of patterned regions that correspond to a first light transmittance area in the light transmittance area, and the plurality of patterned regions and the plurality of second pixel areas are alternately arranged along a first direction in the second display area, characterised in that, a thickness of the common electrode in the patterned regions is smaller than a thickness of the common electrode in a region other than the patterned regions, and is greater than zero.
Dental prosthesis, in particular on implants, optionally for the replacement of an entire dental arch, said dental prosthesis comprising: a structure mainly extending along a direction and having at least one chewing portion developing transverse to said structure, said structure being made through a plurality of fibres, optionally carbon fibres and/or glass fibres, developing along the development of said structure transverse to the development of the chewing portion, said chewing portion being made in a single piece with said structure and being substantially tooth and dental-arch shaped, said chewing portion developing according to a direction of main development between a contact edge suitable for engaging the tissues of the patient and a chewing edge opposite said contact edge, said chewing and/or contact edges being made through said a filler thermosetting resin which is filled with micro particles of fibre; at least one, preferably a plurality of, hooking element, engaged, in particular integrated, in said structure and engageable to a respective implant applied in the mouth of a patient for fixing said dental prosthesis to the tissues of the latter. a structure mainly extending along a direction and having at least one chewing portion developing transverse to said structure, said structure being made through a plurality of fibres, optionally carbon fibres and/or glass fibres, developing along the development of said structure transverse to the development of the chewing portion, said chewing portion being made in a single piece with said structure and being substantially tooth and dental-arch shaped, said chewing portion developing according to a direction of main development between a contact edge suitable for engaging the tissues of the patient and a chewing edge opposite said contact edge, said chewing and/or contact edges being made through said a filler thermosetting resin which is filled with micro particles of fibre; at least one, preferably a plurality of, hooking element, engaged, in particular integrated, in said structure and engageable to a respective implant applied in the mouth of a patient for fixing said dental prosthesis to the tissues of the latter.
A laminate of thermoplastic resin film with vapor-permeable barrier function, wherein said laminate comprises: at least one layer of non-amorphous thermoplastic resin film having a continuous structure in a thickness of 1-120 μm with vapor-permeable barrier function; at least one layer of natural or chemical product layer with a gram weight of 1-250 g/m 2; and one or more resin layers with a gram weight of 0.1 g/m 2 to 550 g/m 2 which are made from thermoplastic resin and/or curable resin, which locate between said thermoplastic resin film and said product layer in order to bond both together, and which have physical interval gaps of 700 nm to 3 mm; wherein the natural or chemical product layer is a discontinuous film, a non-woven product, a viscose fibre product, and/or a textile fiber product; wherein the thermoplastic resin film with vapor-permeable barrier function is formed from a thermoplastic resin composition which, by mass percentage, comprises the following components: 3-95% thermoplastic non-amorphous elastomer resin material with a proportion of 5% or more hydrophilic segment, 1-99% polar thermoplastic resin material, and 0-28% compatibilizer selected from thermoplastic resin material; and wherein said laminate is capable of blocking solid dusts, aerosols, bacteria, virus and liquid with a size larger than 5 nm. at least one layer of non-amorphous thermoplastic resin film having a continuous structure in a thickness of 1-120 μm with vapor-permeable barrier function; at least one layer of natural or chemical product layer with a gram weight of 1-250 g/m 2; and one or more resin layers with a gram weight of 0.1 g/m 2 to 550 g/m 2 which are made from thermoplastic resin and/or curable resin, which locate between said thermoplastic resin film and said product layer in order to bond both together, and which have physical interval gaps of 700 nm to 3 mm; wherein the natural or chemical product layer is a discontinuous film, a non-woven product, a viscose fibre product, and/or a textile fiber product; wherein the thermoplastic resin film with vapor-permeable barrier function is formed from a thermoplastic resin composition which, by mass percentage, comprises the following components: 3-95% thermoplastic non-amorphous elastomer resin material with a proportion of 5% or more hydrophilic segment, 1-99% polar thermoplastic resin material, and 0-28% compatibilizer selected from thermoplastic resin material; and wherein said laminate is capable of blocking solid dusts, aerosols, bacteria, virus and liquid with a size larger than 5 nm.