mhurhangee/ep-ind-claims huggingface dataset:
A hypoxia-inducible factor activator, or a pharmaceutically acceptable salt or solvate thereof, for use in promoting tissue repair in epithelial cells, wherein the HIF activator is selected from a group consisting of: dimethyloxalylglycine (DMOG); N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine; N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine; desferrioxamine; o-phenanthroline; iodochlorohydroxyquinoline; and cobalt chloride heptahydrate, or a pharmaceutically acceptable salt or solvate thereof, and is to be used with a prototypical tissue-protective cytokine, wherein the prototypical tissue-protective cytokine is erythropoietin, or an analogue or derivative thereof, interleukin 3 (IL-3), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 11 (IL-11), leukaemia inhibitory factor or a colony stimulating factor or a pharmaceutically acceptable salt or solvate thereof, which is administered exogenously to the body being treated, wherein the derivative of EPO is desialylated EPO, carbamylated EPO (CEPO), asialoerythropoietin (asialoEPO), glutaraldehyde EPO (GEPO), epopeptide AB, an isoform of EPO, recombinant EPO, mutant S100E of EPO, and the analogue of EPO is pyroglutamate helix B surface peptide (pHBSP).
A driver circuit for powering one or more LEDs, comprising a controllable constant current source for connecting one or more series-connected LEDs, and a switchable current sense resistor (RCS, RCS2) connectable in series with the one or more LEDs, wherein the driver circuit is configured to measure the current through the one or more LEDs via a voltage drop of the current sense resistor (RCS, RCS2) in order to regulate the current to a predetermined value, wherein the switching of the current sense resistor (RCS, RCS2) is controlled by a microcontroller of the driver circuit and the microcontroller further provides a control voltage which adjusts the current generation at the constant current source in accordance with the selected sense resistor (RCS, RCS2), wherein the driver circuit is further configured to switch the current sense resistor (RCS, RCS2) to at least two different values, wherein switching to the lower of the two values for measuring the current through the one or more LEDs in a higher current range and to the higher of the two values for measuring the current through the one or more LEDs in a lower current range, characterised in that the two current ranges partially overlap, and in that the driver circuit is configured to switch the current sense resistor (RCS, RCS2) to the lower value upon reaching the maximum of the lower current range and vice versa to switch back to the higher value only upon reaching the minimum of the higher current range. a switchable current sense resistor (RCS, RCS2) connectable in series with the one or more LEDs, wherein the driver circuit is configured to measure the current through the one or more LEDs via a voltage drop of the current sense resistor (RCS, RCS2) in order to regulate the current to a predetermined value, wherein the switching of the current sense resistor (RCS, RCS2) is controlled by a microcontroller of the driver circuit and the microcontroller further provides a control voltage which adjusts the current generation at the constant current source in accordance with the selected sense resistor (RCS, RCS2), wherein the driver circuit is further configured to switch the current sense resistor (RCS, RCS2) to at least two different values, wherein switching to the lower of the two values for measuring the current through the one or more LEDs in a higher current range and to the higher of the two values for measuring the current through the one or more LEDs in a lower current range, characterised in that the two current ranges partially overlap, and in that the driver circuit is configured to switch the current sense resistor (RCS, RCS2) to the lower value upon reaching the maximum of the lower current range and vice versa to switch back to the higher value only upon reaching the minimum of the higher current range.
A system (10, 40) for photoaltering a region of an eye, the eye having a pupil and an iris, the system comprising: a laser assembly (14, 16, 20, 26, 28) configured to output a pulsed laser beam; a controller (22, 58) coupled to the laser assembly; an image sensor coupled to the controller (22, 58) and configured to capture image data and transmit the image data to the controller to produce the first digital image; a user interface (32, 34) configured to display one of a first digital image of the eye and a second digital image of the eye, the first digital image having a first contrast between the pupil and the iris, the second digital image having a second contrast between the pupil and the iris; the controller being coupled to the user interface and configured to: increase the first contrast between the pupil and the iris of first digital image to the second contrast between the pupil and the iris of the second digital image; and direct the pulsed laser beam to the region of the eye based on one of the first and second digital images, and characterized in that the first digital image is associated with the image data and a default linear gamma function applicable by the image sensor and the second digital image is associated with the image data and a selectable non-linear gamma function applicable by the image sensor. a laser assembly (14, 16, 20, 26, 28) configured to output a pulsed laser beam; a controller (22, 58) coupled to the laser assembly; an image sensor coupled to the controller (22, 58) and configured to capture image data and transmit the image data to the controller to produce the first digital image; a user interface (32, 34) configured to display one of a first digital image of the eye and a second digital image of the eye, the first digital image having a first contrast between the pupil and the iris, the second digital image having a second contrast between the pupil and the iris; the controller being coupled to the user interface and configured to: increase the first contrast between the pupil and the iris of first digital image to the second contrast between the pupil and the iris of the second digital image; and direct the pulsed laser beam to the region of the eye based on one of the first and second digital images, and characterized in that the first digital image is associated with the image data and a default linear gamma function applicable by the image sensor and the second digital image is associated with the image data and a selectable non-linear gamma function applicable by the image sensor.
A portion for a portable electronic device, the portion comprising: a glass fiber laminate body; and a plastic rim disposed at the edges of the body, the rim including a connector (310, 316) configured to couple with a complementary part of the portable electronic device, wherein the rim is thicker than the body and wherein the plastic rim is overmolded to the glass fiber laminate body, wherein the body is generally rectangular in shape and the edges of the body are curved thereby forming a generally rectangular bowl, wherein the plastic rim includes a recess for receiving a functional component of the portable electronic device. a glass fiber laminate body; and a plastic rim disposed at the edges of the body, the rim including a connector (310, 316) configured to couple with a complementary part of the portable electronic device, wherein the rim is thicker than the body and wherein the plastic rim is overmolded to the glass fiber laminate body, wherein the body is generally rectangular in shape and the edges of the body are curved thereby forming a generally rectangular bowl, wherein the plastic rim includes a recess for receiving a functional component of the portable electronic device.
A location server in a cellular network, comprising: means (44, 52, 54, 56, 58) for selectively streaming at least one of service, assistance or measurement data to a terminal using a single secure user plane location session, initiated following a request sent by the terminal, wherein additional assistance data requests in the same secure user plane location session are made, wherein the secure user plane location session is terminated after a designated maximum time.
Method for water quality monitoring by at least one monitoring of proper motions of living test organisms (40a-g), in particular fish and/or daphnia, in a water volume (44a-g), wherein acoustic signals (30a-g) measured over a measuring period are compared to one another, wherein a change in a behaviour of the living test organisms (40a-g) during a course of the measuring period is determined by a change in the signals over the measuring period, characterised in that the proper motions of the living test organisms (40a-g) are monitored via Doppler sonography measuring, wherein an increase or decrease of an agitation is determined on the basis of a frequency shift of the acoustic signals that increases or decreases in the course of the measuring period and wherein an increased respiration frequency is detected via an intensity and frequency of a peak amplitude, allocated to a gill cover movement, in a signal spectrum of the acoustic signals (30a-g) that is implemented as a Doppler spectrum.
Clamping tool provided of a tightening conditions display device, said tool comprising • a body, containing control circuits and a processing electronic unit having at one end a handle for gripping by an operator making the clamping, and on the other end an arm • said arm comprising at its free end a seat wherein can be alternatively pluggable a plurality of inserts suitable for engaging the tool with a corresponding type and/or dimension of a mechanical member on which the tool is destined to operate to carry out a clamping operation, • sensor means being provided on said arm suitable for detecting tightening conditions exerted on said mechanical member, • said display device is controlled by said electronic processing unit and comprises an annular support connected to the tool, to which a plurality of lighting groups are associated, provided along a circle arch long the ring and each one comprising at least two lighting points, the groups being substantially equidistant each other along the ring, said points being destined to lighten when the clamping is finished, characterized in that the processing electronic unit switches on in each point of the plurality of points a progressive sequence with all the points switched off before starting the clamping operation until having all the points switched on when the clamping is finished so as to simulate an arch of a circle extending from a point up to its maximum dimension with all the points switched on, wherein the lighting groups are four arches, each one having a dimension slightly lower than 90°. • a body, containing control circuits and a processing electronic unit having at one end a handle for gripping by an operator making the clamping, and on the other end an arm • said arm comprising at its free end a seat wherein can be alternatively pluggable a plurality of inserts suitable for engaging the tool with a corresponding type and/or dimension of a mechanical member on which the tool is destined to operate to carry out a clamping operation, • sensor means being provided on said arm suitable for detecting tightening conditions exerted on said mechanical member, • said display device is controlled by said electronic processing unit and comprises an annular support connected to the tool, to which a plurality of lighting groups are associated, provided along a circle arch long the ring and each one comprising at least two lighting points, the groups being substantially equidistant each other along the ring, said points being destined to lighten when the clamping is finished, the processing electronic unit switches on in each point of the plurality of points a progressive sequence with all the points switched off before starting the clamping operation until having all the points switched on when the clamping is finished so as to simulate an arch of a circle extending from a point up to its maximum dimension with all the points switched on, wherein the lighting groups are four arches, each one having a dimension slightly lower than 90°.
An isolated nucleic acid molecule encoding a chimeric antigen receptor comprising at least one extracellular antigen binding domain comprising a mesothelin antigen binding domain encoded by a nucleotide sequence comprising SEQ ID NO: 3, 5, or 7, at least one transmembrane domain, and at least one intracellular signaling domain.
A liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65°C and 95°C, and having pH between 5.0 and 6.0 ii) cooling the solution so formed to a temperature equal to or above 35°C and below 40°C under an atmosphere of nitrogen, iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring, iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65°C and 95°C, and having pH between 5.0 and 6.0 ii) cooling the solution so formed to a temperature equal to or above 35°C and below 40°C under an atmosphere of nitrogen, iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring, iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere
Packaging material sealing device, in particular a cross seam packaging material sealing device for a vertical packaging machine, comprising: - a first sealing jaw and at least a second sealing jaw; - at least one movement unit, which comprises a first actuator and at least a second actuator for actuating the two sealing jaws (16, 18) along a sealing direction; and - at least one control unit, wherein the movement unit comprises a first drive shaft, which is connected to the first actuator and allows movement of first sections (50, 52) of the two sealing jaws (16, 18), and at least a second drive shaft, which is connected to the second actuator and allows movement of second sections (60, 62) of the two sealing jaws (16, 18), characterized in that the movement unit comprises a further first actuator and at least a further second actuator for moving the two sealing jaws (16, 18) perpendicular to the sealing direction, wherein the movement unit comprises a first threaded rod connected to the further first actuator and comprises at least a second threaded rod connected to the further second actuator, wherein the two sealing jaws (16, 18) are movable perpendicular to the sealing direction along the two threaded rods (76, 78), wherein the two threaded rods (76, 78) are mounted parallelly to the two drive shafts (36, 38). - a first sealing jaw and at least a second sealing jaw; - at least one movement unit, which comprises a first actuator and at least a second actuator for actuating the two sealing jaws (16, 18) along a sealing direction; and - at least one control unit, wherein the movement unit comprises a first drive shaft, which is connected to the first actuator and allows movement of first sections (50, 52) of the two sealing jaws (16, 18), and at least a second drive shaft, which is connected to the second actuator and allows movement of second sections (60, 62) of the two sealing jaws (16, 18), characterized in that the movement unit comprises a further first actuator and at least a further second actuator for moving the two sealing jaws (16, 18) perpendicular to the sealing direction, wherein the movement unit comprises a first threaded rod connected to the further first actuator and comprises at least a second threaded rod connected to the further second actuator, wherein the two sealing jaws (16, 18) are movable perpendicular to the sealing direction along the two threaded rods (76, 78), wherein the two threaded rods (76, 78) are mounted parallelly to the two drive shafts (36, 38).
An application unit comprising: a container to contain an application material; and an application needle to apply, to a target surface, the application material contained in the container, a first hole being formed in a bottom of the container, a second hole being formed in an upper lid of the container, the application needle being configured to be movable along a line passing through the first hole and the second hole, characterized in that said application needle comprising an upper part having a large diameter shaft arranged to be inserted into the application material container, a fine gap is formed between the wall of second hole and application needle to enable the application needle to move up and down, a third hole being formed in a part of the container for allowing air to be discharged through the third hole when the large-diameter shaft of the application needle is inserted in the application material container, and allowing the air in application material container not to be pressurized when the application material adheres to an upper portion of application needle and also enters the fine gap between the upper portion of application needle and the wall of second hole and thereby hermetically seals upper lid of application material container. a container to contain an application material; and an application needle to apply, to a target surface, the application material contained in the container, a first hole being formed in a bottom of the container, a second hole being formed in an upper lid of the container, the application needle being configured to be movable along a line passing through the first hole and the second hole, characterized in that said application needle comprising an upper part having a large diameter shaft arranged to be inserted into the application material container, a fine gap is formed between the wall of second hole and application needle to enable the application needle to move up and down, a third hole being formed in a part of the container for allowing air to be discharged through the third hole when the large-diameter shaft of the application needle is inserted in the application material container, and allowing the air in application material container not to be pressurized when the application material adheres to an upper portion of application needle and also enters the fine gap between the upper portion of application needle and the wall of second hole and thereby hermetically seals upper lid of application material container.
A noise cancellation enabled audio device, in particular a headphone, the audio device comprising - a speaker which is arranged within the audio device and which has a preferential side for sound emission, - a first cavity enclosing a first volume of air, where the first cavity is arranged at the preferential side for sound emission of the speaker, - an error microphone which is arranged within a second cavity within the audio device, wherein - the first cavity comprises a first opening to an outside of the audio device and the second cavity comprises a second opening to the outside of the audio device, - the first and the second opening (25, 26) are both arranged on a side of the audio device which is arranged to face an ear canal of a user, - the second cavity is separated from the first cavity by a separating wall, and - the error microphone terminates flush with a housing of the audio device. - a speaker which is arranged within the audio device and which has a preferential side for sound emission, - a first cavity enclosing a first volume of air, where the first cavity is arranged at the preferential side for sound emission of the speaker, - an error microphone which is arranged within a second cavity within the audio device, wherein - the first cavity comprises a first opening to an outside of the audio device and the second cavity comprises a second opening to the outside of the audio device, - the first and the second opening (25, 26) are both arranged on a side of the audio device which is arranged to face an ear canal of a user, - the second cavity is separated from the first cavity by a separating wall, and - the error microphone terminates flush with a housing of the audio device.
Battery assembly for a motor vehicle, - having a battery housing having a first housing part and a second housing part, which battery housing has a receiving space for the reception of at least one battery module, - wherein the battery housing is designed so as to be able to be divided by the first housing part and the second housing part in a motor vehicle Z direction and one of the housing parts (4, 5) is provided for arrangement on a vehicle underfloor of the motor vehicle, - wherein at least one crossmember arranged on the battery housing divides the receiving space at least partially into a first region and a second region, - wherein the at least one battery module is arranged in the first region or the second region, - wherein the crossmember has, in the region of a connecting point between the first housing part and the second housing part, a positioning device for the simplified and guided connection of the first housing part with the second housing part of the battery housing, characterised in that the positioning device is in the form of a toothing, wherein the crossmember has at least on one side tooth elements which engage in receiving elements, corresponding thereto, on the first housing part or on the second housing part. - having a battery housing having a first housing part and a second housing part, which battery housing has a receiving space for the reception of at least one battery module, - wherein the battery housing is designed so as to be able to be divided by the first housing part and the second housing part in a motor vehicle Z direction and one of the housing parts (4, 5) is provided for arrangement on a vehicle underfloor of the motor vehicle, - wherein at least one crossmember arranged on the battery housing divides the receiving space at least partially into a first region and a second region, - wherein the at least one battery module is arranged in the first region or the second region, - wherein the crossmember has, in the region of a connecting point between the first housing part and the second housing part, a positioning device for the simplified and guided connection of the first housing part with the second housing part of the battery housing,
An immunogenic composition comprising GNA1870, NadA and Lipo28, wherein said antigens, where present in an outer membrane vesicle, have been upregulated in the outer membrane vesicle, with the proviso that the immunogenic composition is not one of the following compositions disclosed in WO 2004/032958: - a mixture of a 'NadA' protein; a '741' protein; a '936' protein; a '953' protein; and a '287' protein; - a mixture of ΔG287-953 hybrid protein, 936-ΔG741 hybrid protein, NadA protein and an aluminium hydroxide adjuvant; - a mixture of ΔG287-953 hybrid protein, 936-ΔG741 hybrid protein, NadA protein and an aluminium hydroxide adjuvant, in combination with OMVs prepared from strain H44/76; or a mixture of ΔG287-953 hybrid protein, 936-ΔG741 hybrid protein, NadA protein and an aluminium hydroxide adjuvant, in combination with OMVs prepared from strain 394/98. - a mixture of a 'NadA' protein; a '741' protein; a '936' protein; a '953' protein; and a '287' protein; - a mixture of ΔG287-953 hybrid protein, 936-ΔG741 hybrid protein, NadA protein and an aluminium hydroxide adjuvant; - a mixture of ΔG287-953 hybrid protein, 936-ΔG741 hybrid protein, NadA protein and an aluminium hydroxide adjuvant, in combination with OMVs prepared from strain H44/76; or