An integrated surgical system for reducing intraocular pressure in an eye having a cornea, an anterior chamber, and an irido-corneal angle comprising an aqueous humor outflow pathway formed of a trabecular meshwork, a Schlemm's canal, and one or more collector channels branching from the Schlemm's canal, the system comprising: a first optical subsystem including: a window configured to be coupled to the cornea, and an exit lens configured to be coupled to the window, wherein each of the window and exit lens comprises a concave surface and a convex surface, and the concave surface of the exit lens is configured to couple to the convex surface of the window; a second optical subsystem optically coupled with the first optical subsystem and including: an optical coherence tomography imaging apparatus configured to output an OCT beam, a laser source configured to output a laser beam, and a plurality of components configured to one or more of condition, scan, combine, and direct one or more of the OCT beam and the laser beam; and a control system coupled to the second optical subsystem and configured to: instruct the OCT imaging apparatus to output an OCT beam and the laser source to output a laser beam, for delivery through the first optical subsystem, the cornea, and the anterior chamber into the irido-corneal angle, and instruct the laser source to modify a volume of ocular tissue within the outflow pathway to reduce a pathway resistance present in one or more of the trabecular meshwork, the Schlemm's canal, and the one or more collector channels by applying the laser beam to ocular tissue defining the volume to thereby cause photo-disruptive interaction with the ocular tissue to reduce the pathway resistance or create a new outflow pathway. a first optical subsystem including: a window configured to be coupled to the cornea, and an exit lens configured to be coupled to the window, wherein each of the window and exit lens comprises a concave surface and a convex surface, and the concave surface of the exit lens is configured to couple to the convex surface of the window; a second optical subsystem optically coupled with the first optical subsystem and including: an optical coherence tomography imaging apparatus configured to output an OCT beam, a laser source configured to output a laser beam, and a plurality of components configured to one or more of condition, scan, combine, and direct one or more of the OCT beam and the laser beam; and a control system coupled to the second optical subsystem and configured to: instruct the OCT imaging apparatus to output an OCT beam and the laser source to output a laser beam, for delivery through the first optical subsystem, the cornea, and the anterior chamber into the irido-corneal angle, and instruct the laser source to modify a volume of ocular tissue within the outflow pathway to reduce a pathway resistance present in one or more of the trabecular meshwork, the Schlemm's canal, and the one or more collector channels by applying the laser beam to ocular tissue defining the volume to thereby cause photo-disruptive interaction with the ocular tissue to reduce the pathway resistance or create a new outflow pathway. instruct the OCT imaging apparatus to output an OCT beam and the laser source to output a laser beam, for delivery through the first optical subsystem, the cornea, and the anterior chamber into the irido-corneal angle, and instruct the laser source to modify a volume of ocular tissue within the outflow pathway to reduce a pathway resistance present in one or more of the trabecular meshwork, the Schlemm's canal, and the one or more collector channels by applying the laser beam to ocular tissue defining the volume to thereby cause photo-disruptive interaction with the ocular tissue to reduce the pathway resistance or create a new outflow pathway.