mhurhangee/ep-ind-claims huggingface dataset:
A method of labeling a nucleic acid in a sample, comprising: hybridizing a target with a first oligonucleotide comprising a universal adaptor sequence and a target-specific sequence; extending said first oligonucleotide to generate a first nucleotide sequence; hybridizing said first nucleotide sequence with a second oligonucleotide; extending said second oligonucleotide to generate a second nucleotide sequence; hybridizing said second nucleotide sequence with a third oligonucleotide comprising a binding site for a first amplification primer and the universal adaptor sequence, wherein the third oligonucleotide comprises a stochastic barcode, wherein the stochastic barcode comprises a molecular label; extending said third oligonucleotide to generate a third nucleotide sequence; and amplifying said third nucleotide sequence using a first amplification primer to generate a plurality of a fourth nucleotide sequences, wherein each of the plurality of the fourth nucleotide sequences comprises said target and the stochastic barcode, wherein the target is an mRNA molecule; and wherein the molecular label comprises a nucleic acid sequence that provides a counter for the specific occurrence of the target nucleic acid. hybridizing a target with a first oligonucleotide comprising a universal adaptor sequence and a target-specific sequence; extending said first oligonucleotide to generate a first nucleotide sequence; hybridizing said first nucleotide sequence with a second oligonucleotide; extending said second oligonucleotide to generate a second nucleotide sequence; hybridizing said second nucleotide sequence with a third oligonucleotide comprising a binding site for a first amplification primer and the universal adaptor sequence, wherein the third oligonucleotide comprises a stochastic barcode, wherein the stochastic barcode comprises a molecular label; extending said third oligonucleotide to generate a third nucleotide sequence; and amplifying said third nucleotide sequence using a first amplification primer to generate a plurality of a fourth nucleotide sequences, wherein each of the plurality of the fourth nucleotide sequences comprises said target and the stochastic barcode, wherein the target is an mRNA molecule; and wherein the molecular label comprises a nucleic acid sequence that provides a counter for the specific occurrence of the target nucleic acid.
A subtilisin variant having protease activity comprising the substitutions corresponding to Y217X and N218Z of SEQ ID NO: 2, wherein X and Z are selected from the group consisting of K, H, R, D, E, S and T, wherein when X is either K, H or R then Z is also selected from K, H or R, and wherein when X is either D, E, S or T then Z is also selected from D, E, S or T, wherein the variant has an improved wash performance on egg stains compared to the protease with SEQ ID NO: 2, and wherein the variant has at least 85% sequence identity to the mature polypeptide of SEQ ID NO: 2.
A β-Ga 2 O 3 -based single crystal substrate, comprising a β-Ga 2 O 3 -based single crystal, wherein the β-Ga 2 O 3 -based single crystal comprises a full width at half maximum of an x-ray rocking curve of less than 75 seconds, wherein the β-Ga 2 O 3 -based single crystal comprises a main surface with a plane orientation of ( -201), or, and wherein the substrate is free from any twinned crystal.
An article having an environmental barrier coating, said article comprising a substrate comprising a ceramic matrix composite and an environmental barrier coating deposited on the surface of the substrate, the environmental barrier coating comprising: a bond coat layer comprising silicon; and at least one rare earth silicate-based hermetic layer deposited on the bond coat layer by thermal spraying, wherein said rare earth silicate-based hermetic layer comprises a thermal sprayed coating comprising a rare earth silicate having a hermetic microstructure having a density of 85% or more of its theoretical density and wherein the hermetic microstructure comprises a closed porosity, said closed porosity comprising a porosity by volume of less than 15 percent. a bond coat layer comprising silicon; and at least one rare earth silicate-based hermetic layer deposited on the bond coat layer by thermal spraying, wherein said rare earth silicate-based hermetic layer comprises a thermal sprayed coating comprising a rare earth silicate having a hermetic microstructure having a density of 85% or more of its theoretical density and wherein the hermetic microstructure comprises a closed porosity, said closed porosity comprising a porosity by volume of less than 15 percent.
A control device that is comprised in a mobile object main body and that is configured to control an imaging device, the imaging device performing imaging of a target object and comprising an image data acquisition device and a three-dimensional data acquisition device that are calibrated, wherein the control device is configured to acquire, for the target object, unit image data in which image data acquired for each angle of view of the image data acquisition device and three-dimensional data acquired by the three-dimensional data acquisition device are associated with each other from the imaging device, characterised in that: the control device is configured to perform plane estimation on an imaging target, based on the three-dimensional data, determines whether the imaging target is a plane, and determines, in the case where it is determined that the imaging target is the plane, a first distance which is a movement distance of the imaging device until next unit image data is acquired, based on information on the plane, wherein in the case where it is determined that the imaging target is not the plane, the control device is configured to determine a second distance shorter than the first distance as a distance until next unit image data is acquired. the control device is configured to acquire, for the target object, unit image data in which image data acquired for each angle of view of the image data acquisition device and three-dimensional data acquired by the three-dimensional data acquisition device are associated with each other from the imaging device, characterised in that: the control device is configured to perform plane estimation on an imaging target, based on the three-dimensional data, determines whether the imaging target is a plane, and determines, in the case where it is determined that the imaging target is the plane, a first distance which is a movement distance of the imaging device until next unit image data is acquired, based on information on the plane, wherein in the case where it is determined that the imaging target is not the plane, the control device is configured to determine a second distance shorter than the first distance as a distance until next unit image data is acquired.
A knitted component for incorporating into an article of footwear, the knitted component comprising: a plurality of lenticular knit structures, each of the lenticular knit structures including a first portion formed using a first yarn on one side of the lenticular knit structure and a second portion formed using a second yarn disposed on an opposite side of the lenticular knit structure, the first yarn and the second yarn being different; and a base portion, the lenticular knit structure extending away from the base portion in a vertical direction; and wherein the first portion of the lenticular knit structure is associated with a first visual effect when the knitted component is viewed from a first viewing angle and the second portion of the at least one lenticular knit structure is associated with a second visual effect when the knitted component is viewed from a second viewing angle that is different than the first viewing angle, characterised in that the base portion is disposed between adjacent lenticular knit structures, and in that the knitted component is configured such that the base portion is revealable from between the adjacent lenticular knit structures upon stretching of the knitted component. a plurality of lenticular knit structures, each of the lenticular knit structures including a first portion formed using a first yarn on one side of the lenticular knit structure and a second portion formed using a second yarn disposed on an opposite side of the lenticular knit structure, the first yarn and the second yarn being different; and a base portion, the lenticular knit structure extending away from the base portion in a vertical direction; and wherein the first portion of the lenticular knit structure is associated with a first visual effect when the knitted component is viewed from a first viewing angle and the second portion of the at least one lenticular knit structure is associated with a second visual effect when the knitted component is viewed from a second viewing angle that is different than the first viewing angle, characterised in that the base portion is disposed between adjacent lenticular knit structures, and in that the knitted component is configured such that the base portion is revealable from between the adjacent lenticular knit structures upon stretching of the knitted component.
An apparatus of an evolved universal terrestrial radio access network, E-UTRAN, operable to assist a serving user equipment, UE, and a requesting UE in operator-assisted device-to-device, D2D, communications, the apparatus comprising: memory configured to store discovery configuration information; and one or more processors configured to: determine when the serving UE and the requesting UE are within a wireless local area network, WLAN, direct communications range; generate, at the apparatus of the E-UTRAN, D2D discovery configuration information; and characterised in that the one or more processors are further configured to: process, at the apparatus of the E-UTRAN, the D2D discovery configuration information for transmission to the serving UE to enable the serving UE to perform operator-assisted D2D communications with the requesting UE when the serving UE and the requesting UE are within the WLAN direct communication range, wherein the apparatus of the E-UTRAN is configured to authenticate the serving UE and the requesting UE via an operator network authentication protocol to enable security on a D2D-assisted WLAN direct communications link between the serving UE and the requesting UE. memory configured to store discovery configuration information; and one or more processors configured to: determine when the serving UE and the requesting UE are within a wireless local area network, WLAN, direct communications range; generate, at the apparatus of the E-UTRAN, D2D discovery configuration information; and characterised in that the one or more processors are further configured to: process, at the apparatus of the E-UTRAN, the D2D discovery configuration information for transmission to the serving UE to enable the serving UE to perform operator-assisted D2D communications with the requesting UE when the serving UE and the requesting UE are within the WLAN direct communication range, wherein the apparatus of the E-UTRAN is configured to authenticate the serving UE and the requesting UE via an operator network authentication protocol to enable security on a D2D-assisted WLAN direct communications link between the serving UE and the requesting UE. determine when the serving UE and the requesting UE are within a wireless local area network, WLAN, direct communications range; generate, at the apparatus of the E-UTRAN, D2D discovery configuration information; and characterised in that the one or more processors are further configured to: process, at the apparatus of the E-UTRAN, the D2D discovery configuration information for transmission to the serving UE to enable the serving UE to perform operator-assisted D2D communications with the requesting UE when the serving UE and the requesting UE are within the WLAN direct communication range, wherein the apparatus of the E-UTRAN is configured to authenticate the serving UE and the requesting UE via an operator network authentication protocol to enable security on a D2D-assisted WLAN direct communications link between the serving UE and the requesting UE.
A hand-held scanning device comprising: a) a housing having walls bounding an interior, and a window; b) a generally planar printed circuit board mounted in said interior, wherein said printed circuit board is coplanar to the window; and c) an optical scanning assembly mounted on said printed circuit board and including a scanner for directing a light beam through the window at an acute angle relative to said printed circuit board exteriorly of the housing to an indicium to be scanned, and a detector for detecting light reflected from the indicium being scanned and for providing data signals representative of the indicium. a) a housing having walls bounding an interior, and a window; b) a generally planar printed circuit board mounted in said interior, wherein said printed circuit board is coplanar to the window; and c) an optical scanning assembly mounted on said printed circuit board and including a scanner for directing a light beam through the window at an acute angle relative to said printed circuit board exteriorly of the housing to an indicium to be scanned, and a detector for detecting light reflected from the indicium being scanned and for providing data signals representative of the indicium.
A pressing tool for producing a workpiece, comprising a base structure of metal, a pressing surface, and a lacquer or plastic layer (11, 31), in which mineral particles (12, 32) are embedded, arranged on the base structure, and at least partially forming the pressing surface, wherein the pressing surface has a structure of protrusions and recesses; the base structure is structured in accordance with the structure of the pressing surface; characterized in that the lacquer or plastic layer with the embedded mineral particles is formed partially, and is arranged on the base structure only in predetermined regions, which in particular are assigned to the protrusions or predetermined protrusions of the pressing surface. the pressing surface has a structure of protrusions and recesses; the base structure is structured in accordance with the structure of the pressing surface; characterized in that the lacquer or plastic layer with the embedded mineral particles is formed partially, and is arranged on the base structure only in predetermined regions, which in particular are assigned to the protrusions or predetermined protrusions of the pressing surface.
Use of a device as a laying aid for tiling work using adhesive and/or mortar, the device comprising a main element (7, 8) having a support region for planar support on a surface to be covered with tiles and a tile support region for supporting tiles, the tile support region comprising at least two rib-like spacing elements which extend perpendicularly to a plane defined by the tile support region and which are arranged in said plane at an angle of an integer multiple of 90° relative to one another, which spacing elements have a thickness corresponding to a desired joint spacing, the main element (7, 8) being designed as a disc-like element having a main surface that is smaller than the main surface of the tiles to be laid, characterised in that the support region and/or the tile support region comprises elevations for preventing undesired shifting of the laying aid with respect to the substrate and/or shifting of the tiles with respect to the laying aid.
A composition comprising the following formula and optionally salts thereof: wherein R 1 is H, R 2, and R 3 are butyl or n-butyl; wherein R 4 is C 4 -C 20 alkyl or alkenyl; and X - is a counterion; optionally further comprising at least one polar or nonpolar solvent or a mixture thereof. wherein R 1 is H, R 2, and R 3 are butyl or n-butyl; wherein R 4 is C 4 -C 20 alkyl or alkenyl; and X - is a counterion; optionally further comprising at least one polar or nonpolar solvent or a mixture thereof.
A method for diagnosing cancer in a subject, the method comprising measuring histone 2B protein monoubiquitination in a first cell obtained from the subject, wherein decreased histone 2B protein monoubiquitination in said first cell compared to that of a second non-cancerous cell is diagnostic of cancer.
A sound penetrating OLED, Organic Light Emitting Diode, display (100,300,520) apparatus for displaying images, comprising: an OLED display panel with a plurality of pixels; a plurality of matrix speakers; a plurality of holes which are distributed in the OLED display panel in such a way that one hole is assigned to each pixel (31,131) in order for sound from the matrix speakers disposed at a back side of the OLED display panel to penetrate; a driving circuit (110,120) for driving the OLED display panel; a protecting layer which is attached to a back side of the OLED display panel or is disposed close to the same and is formed of holes matching with the holes of the panel; wherein the plurality of matrix speakers are positioned such that the sound from the plurality of matrix speakers passes through the protecting layer. an OLED display panel with a plurality of pixels; a plurality of matrix speakers; a plurality of holes which are distributed in the OLED display panel in such a way that one hole is assigned to each pixel (31,131) in order for sound from the matrix speakers disposed at a back side of the OLED display panel to penetrate; a driving circuit (110,120) for driving the OLED display panel; a protecting layer which is attached to a back side of the OLED display panel or is disposed close to the same and is formed of holes matching with the holes of the panel; wherein the plurality of matrix speakers are positioned such that the sound from the plurality of matrix speakers passes through the protecting layer.
An equipotential bonding rail in the form of a plane material strip of metal, to which can be attached or is attached a tensioning plate of metal by means of attachment means passing through the parts, between the material strip and the tensioning plate a plane foundation earth electrode to be disposed transversely to the longitudinal extension of the material strip being clampable or being clamped, characterized by that the material strip, at least in the region covered by the tensioning plate, forms a bending-resistant structure such that it withstands the tensioning forces applied by the attachment means without being bent, and the foundation earth electrode, in the clamped position, rests over its full width flatly against the plane material strip, the plane material strip, at least in the region covered by the tensioning plate, having a profile-shaped cross-section, and the plane material strip, at least in the region covered by the tensioning plate, having a U-shaped cross-section, the foundation earth electrode resting outside on the base of the U-shape and being clamped thereonto.
An anti-CD38 antibody for use in treating a subject having a CD38-positive hematological malignancy, wherein the anti-CD38 antibody comprises a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 sequences of SEQ ID NOs: 6, 7 and 8, respectively, and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 sequences of SEQ ID NOs: 9, 10 and 11, respectively, wherein the anti-CD38 antibody is of IgG1 isotype and wherein the treatment also comprises administering a survivin inhibitor, wherein the survivin inhibitor is YM155.
Method for producing a meat-free meat-substitute or imitation-meat product, characterized in that fruit bodies of edible mushrooms are broken up into pieces in the first step, at least one portion of the fruit bodies being broken up into pieces that have a minimum extension of 3 mm, ingredients comprising the broken-up fruit bodies of edible mushrooms in the range of from 40 to 90 wt.%, plant oil in the range of from 2 to 20 wt.%, a starch source, in particular cooked rice, in the range of from 2 to 15 wt.%, animal and/or plant proteins in the range of from 4 to 15 wt.% and salt in the range of from 1 to 3 wt.% are mixed to form a homogenous production compound in the second step, the production compound is filled into at least one mold in the third step, the production compound is heated in the at least one mold in the fourth step such that the plant or animal protein solidifies in the optionally open or closed mold.
A straw for the conservation of small quantities of substances, in particular biological substances, said straw comprising a segment of tube provided, inside one end, with a stopper including gel powder, wherein said straw stopper includes a thermoplastics material core (4, 43) sheathed with filaments constituting a sheath (5, 53).
A method performed by a wireless device configured to support two or more contemporaneous links with two or more corresponding wireless access points, the method comprising: - receiving a separate maximum transmit power value for the wireless device for each contemporaneous link; - determining that contemporaneous transmission will be performed; and - applying power control to transmissions on each contemporaneous link in subframe k based on the maximum transmit power value corresponding to the respective link, characterized in that the determination that contemporaneous transmission will be performed is based on having received more than one uplink grant with respect to a subframe k. - receiving a separate maximum transmit power value for the wireless device for each contemporaneous link; - determining that contemporaneous transmission will be performed; and - applying power control to transmissions on each contemporaneous link in subframe k based on the maximum transmit power value corresponding to the respective link,
An apparatus for transcutaneous delivery of a medical therapy, comprising: a shell; a core, concentrically disposed within the shell, including one or more working channels, the one or more working channels including a first working channel and a second working channel; a proximal flange disposed at a proximal end of the shell; and a distal flange disposed at a distal end of the shell, wherein the first working channel and the second working channel are offset by a triangulation angle, the triangulation angle describing a relative arrangement of a longitudinal axis of the first working channel and a longitudinal axis of the second working channel, wherein an aperture of the first working channel is larger than an aperture of the second working channel, and wherein the distal flange is configured to be folded into the shell and held in position by a spacer in an insertion state, the spacer maintaining a distance between the proximal flange and a surface of the core. a shell; a core, concentrically disposed within the shell, including one or more working channels, the one or more working channels including a first working channel and a second working channel; a proximal flange disposed at a proximal end of the shell; and a distal flange disposed at a distal end of the shell, wherein the first working channel and the second working channel are offset by a triangulation angle, the triangulation angle describing a relative arrangement of a longitudinal axis of the first working channel and a longitudinal axis of the second working channel, wherein an aperture of the first working channel is larger than an aperture of the second working channel, and wherein the distal flange is configured to be folded into the shell and held in position by a spacer in an insertion state, the spacer maintaining a distance between the proximal flange and a surface of the core.