A system to acquire image data of a subject with an imaging system, comprising: an annular gantry configured to completely annularly encompass a subject; an x-ray source movable within the annular gantry housing; a detector moveable within the annular gantry housing to detect x-rays emitted from the x-ray source that pass through the subject, wherein the imaging system is adapted such that said moving of the detector also includes moving the source, which is substantially diametrically opposed to the detector; and the system to acquire image data further comprising a processor system configured to execute instructions to: acquire initial image data of at least a portion of the subject by transfer via a connection with the imaging system; construct an initial three-dimensional model of the portion of the subject with the initial image data, prior to a procedure being performed on the portion of the subject; acquire, by transfer via a connection with the imaging system, discriminatory discrete location image data of the subject after the procedure has been performed on the subject; compare the acquired discriminatory discrete location image data to the constructed initial three-dimensional model of the portion of the subject; identify specific regions of threshold change between the acquired discriminatory discrete location image data and the constructed initial three-dimensional model of the portion of the subject; and determine a comparative path along which a detector in the gantry shall move to acquire comparative image data based upon the identified regions of change. an annular gantry configured to completely annularly encompass a subject; an x-ray source movable within the annular gantry housing; a detector moveable within the annular gantry housing to detect x-rays emitted from the x-ray source that pass through the subject, wherein the imaging system is adapted such that said moving of the detector also includes moving the source, which is substantially diametrically opposed to the detector; and the system to acquire image data further comprising a processor system configured to execute instructions to: acquire initial image data of at least a portion of the subject by transfer via a connection with the imaging system; construct an initial three-dimensional model of the portion of the subject with the initial image data, prior to a procedure being performed on the portion of the subject; acquire, by transfer via a connection with the imaging system, discriminatory discrete location image data of the subject after the procedure has been performed on the subject; compare the acquired discriminatory discrete location image data to the constructed initial three-dimensional model of the portion of the subject; identify specific regions of threshold change between the acquired discriminatory discrete location image data and the constructed initial three-dimensional model of the portion of the subject; and determine a comparative path along which a detector in the gantry shall move to acquire comparative image data based upon the identified regions of change. acquire initial image data of at least a portion of the subject by transfer via a connection with the imaging system; construct an initial three-dimensional model of the portion of the subject with the initial image data, prior to a procedure being performed on the portion of the subject; acquire, by transfer via a connection with the imaging system, discriminatory discrete location image data of the subject after the procedure has been performed on the subject; compare the acquired discriminatory discrete location image data to the constructed initial three-dimensional model of the portion of the subject; identify specific regions of threshold change between the acquired discriminatory discrete location image data and the constructed initial three-dimensional model of the portion of the subject; and determine a comparative path along which a detector in the gantry shall move to acquire comparative image data based upon the identified regions of change.