An ophthalmic treatment system for performing therapy on target tissue in a patient's eye, comprising: a light source for producing treatment light; a delivery system for delivering the treatment light to the target tissue in the patient's eye; a camera for capturing a live image of the patient's eye; control electronics for: controlling the delivery system; applying an affine transformation to a pre-treatment image of the patient's eye, wherein the affine transform stretches or morphs the pre-treatment image of the target tissue to fit the pre-treatment image of the target tissue to the live image of the target tissue; registering the transformed pre-treatment image of the patient's eye to the live image captured by the camera, wherein the transformed pre-treatment image includes a treatment template that identifies the target tissue within the patient's eye, and wherein the transformed pre-treatment image is registered by tracking movement of the patient's eye by fitting a current frame of the live image of the target tissue to a previous frame of the live image of the target tissue; and verifying whether or not the delivery system is aligned to the target tissue defined by the treatment template; and a trigger device connected to the control electronics, wherein in response to both an activation of the trigger device and the verification that the delivery system is aligned to the target tissue, the control electronics are configured to control the delivery system to project the treatment light onto the target tissue in the patient's eye. a light source for producing treatment light; a delivery system for delivering the treatment light to the target tissue in the patient's eye; a camera for capturing a live image of the patient's eye; control electronics for: controlling the delivery system; applying an affine transformation to a pre-treatment image of the patient's eye, wherein the affine transform stretches or morphs the pre-treatment image of the target tissue to fit the pre-treatment image of the target tissue to the live image of the target tissue; registering the transformed pre-treatment image of the patient's eye to the live image captured by the camera, wherein the transformed pre-treatment image includes a treatment template that identifies the target tissue within the patient's eye, and wherein the transformed pre-treatment image is registered by tracking movement of the patient's eye by fitting a current frame of the live image of the target tissue to a previous frame of the live image of the target tissue; and verifying whether or not the delivery system is aligned to the target tissue defined by the treatment template; and controlling the delivery system; applying an affine transformation to a pre-treatment image of the patient's eye, wherein the affine transform stretches or morphs the pre-treatment image of the target tissue to fit the pre-treatment image of the target tissue to the live image of the target tissue; registering the transformed pre-treatment image of the patient's eye to the live image captured by the camera, wherein the transformed pre-treatment image includes a treatment template that identifies the target tissue within the patient's eye, and wherein the transformed pre-treatment image is registered by tracking movement of the patient's eye by fitting a current frame of the live image of the target tissue to a previous frame of the live image of the target tissue; and verifying whether or not the delivery system is aligned to the target tissue defined by the treatment template; and a trigger device connected to the control electronics, wherein in response to both an activation of the trigger device and the verification that the delivery system is aligned to the target tissue, the control electronics are configured to control the delivery system to project the treatment light onto the target tissue in the patient's eye.