mhurhangee/ep-ind-claims huggingface dataset:
A compound of the formula: or or a pharmaceutically acceptable salt thereof, where D is an alkyl or alkenyl group having 6 to 10 carbon atoms; R 1 and R 2 are taken together to form an optionally substituted 5- to 7-membered heterocyclic ring containing 0 or 1 additional N, S, or O atoms, or an optionally substituted 5- to 7-membered heterocyclic ring containing 0 or 1 additional N, S, or O atoms fused to an optionally substituted 5- to 7-membered carbocyclic or heterocyclic ring; R 3, R 4, R 6, and R 8 are independently chosen from hydrogen, C 1 -C 4 alkyl, and (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl; R 9 is hydroxyl, amino,, -NR 10 R 11, -OR 12,, or -NR 10 SO 2 R 11, R 10, R 11, and R 12 are independently at each occurrence hydrogen, or C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (aryl)C 0 -C 2 alkyl, (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, (C 3 -C 7 cycloalkenyl)C 0 -C 2 alkyl, (heterocycloalkyl)C 0 -C 2 alkyl, or (5- to 10-membered heteroaryl)C 0 -C 2 alkyl, each of which is optionally substituted; n is 0; M is hydrogen, halogen, hydroxyl, C 1 -C 2 alkyl, or C 1 -C 2 alkoxy, Y is O; Z is a group of the formula where R 21 represents from 0 to 3 groups independently chosen from halogen, hydroxyl, amino, cyano,-CONH 2, -COOH, C 1 -C 4 alkyl, C 2 -C 4 alkanoyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, mono- and di-C 1 -C 4 alkylamino, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy; R 22 is hydrogen, halogen, hydroxyl, amino, cyano, -CONH 2, -COOH, C 1 -C 4 alkyl, C 2 -C 4 alkanoyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, mono- and di-C 1 -C 4 alkylamino, C 1 -C 4 alkylester, C 1 -C 2 haloalkyl, and C 1 -C 2 haloalkoxy, or R 22 is (C 3 -C 7 cycloalkyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkyl, (phenyl)C 0 -C 2 alkoxy, (5- or 6-membered heteroaryl)C 0 -C 2 alkyl, (5- or 6-membered heteroaryl)C 0 -C 2 alkoxy, naphthyl, indanyl, (5- or 6-membered heterocycloalkyl)C 0 -C 2 alkyl, or 9- or 10 membered bicyclic heteroaryl, each of which is substituted with 0, 1, or 2 substituents independently chosen from (i) halogen, hydroxyl, amino, cyano, nitro, -COOH, -CONH 2, CH 3 (C=O)NH-, =NOH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 hydroxyalkyl, mono- and di-C 1 -C 4 alkylamino,-NR 10 SO 2 R 11, -C OR 11, -NR 10 COR 11, -NR 10 C OR 11, trifluoromethyl, and trifluoromethoxy, and (ii) phenyl and 5- or 6-membered heteroaryl, each of which is substituted with 0 or 1 or more of halogen, hydroxyl, C 1 -C 4 alkyl, and C 1 -C 2 alkoxy; and R 16 represents 0 to 4 substituents is independently chosen at from halogen, C 1 -C 2 alkyl, and C 1 -C 2 alkoxy. (i) halogen, hydroxyl, amino, cyano, nitro, -COOH, -CONH 2, CH 3 (C=O)NH-, =NOH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 hydroxyalkyl, mono- and di-C 1 -C 4 alkylamino,-NR 10 SO 2 R 11, -C OR 11, -NR 10 COR 11, -NR 10 C OR 11, trifluoromethyl, and trifluoromethoxy, and (ii) phenyl and 5- or 6-membered heteroaryl, each of which is substituted with 0 or 1 or more of halogen, hydroxyl, C 1 -C 4 alkyl, and C 1 -C 2 alkoxy; and
A staple cartridge assembly for use with a surgical stapler, comprising: a cartridge body (1052, 1054) having a plurality of staple cavities configured to seat staples therein; a biologic tissue membrane (404, 404', 504, 604); a synthetic layer (402, 402', 502, 602) associated with the membrane such that the synthetic layer is configured to provide structural integrity to the membrane so as to allow the membrane to be securely coupled to the cartridge body; wherein the membrane (404, 404', 504, 604) and synthetic layer (402, 402', 502, 602) are configured to be securely attached to tissue by staples in the cartridge, and wherein the biologic tissue membrane (404, 404', 504, 604 2304) and the synthetic layer (402, 402', 502, 602, 2302) are configured to be snap-fit together. a cartridge body (1052, 1054) having a plurality of staple cavities configured to seat staples therein; a biologic tissue membrane (404, 404', 504, 604); a synthetic layer (402, 402', 502, 602) associated with the membrane such that the synthetic layer is configured to provide structural integrity to the membrane so as to allow the membrane to be securely coupled to the cartridge body; wherein the membrane (404, 404', 504, 604) and synthetic layer (402, 402', 502, 602) are configured to be securely attached to tissue by staples in the cartridge, and wherein the biologic tissue membrane (404, 404', 504, 604 2304) and the synthetic layer (402, 402', 502, 602, 2302) are configured to be snap-fit together.
An effervescent composition in solid form comprising: - an acid-base system comprising an organic acid and a salt of the carbonate and/or bicarbonate anion; said salt being present in an amount comprised from 1 to 15% by weight, relative to the total weight of the composition, with the proviso that the composition contains neither adipic acid nor ascorbic acid, - a mixture comprising microcrystalline cellulose and arabinogalactan, wherein said microcrystalline cellulose and arabinogalactan are present in a ratio by weight comprised from 1:1 to 3:1, - at least one probiotic bacterial strain having the ability to reduce and/or eliminate the presence of pathogenic agents selected from the group comprising: Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, Gardnerella vaginalis, Trichomonas vaginalis, Neisseria gonorrhoeae, Escherichia coli, Herpes simplex and Haemophilus ducreyi, said composition being for use in vaginal applications for the treatment of vaginal infections. - an acid-base system comprising an organic acid and a salt of the carbonate and/or bicarbonate anion; said salt being present in an amount comprised from 1 to 15% by weight, relative to the total weight of the composition, with the proviso that the composition contains neither adipic acid nor ascorbic acid, - a mixture comprising microcrystalline cellulose and arabinogalactan, wherein said microcrystalline cellulose and arabinogalactan are present in a ratio by weight comprised from 1:1 to 3:1, - at least one probiotic bacterial strain having the ability to reduce and/or eliminate the presence of pathogenic agents selected from the group comprising: Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, Gardnerella vaginalis, Trichomonas vaginalis, Neisseria gonorrhoeae, Escherichia coli, Herpes simplex and Haemophilus ducreyi, said composition being for use in vaginal applications for the treatment of vaginal infections.
A method of controlling a thermal actuator of a microvalve using a controller (154, 184, 212) to supply a voltage to the thermal actuator, the method comprising the steps of: (a) providing an initial constant voltage (80, 82) from the controller (154, 184, 212) to the thermal actuator which is effective to actuate the microvalve; and (b) providing a pulsed voltage (84, 86, 88, 90) from the controller (154, 184, 212) to the thermal actuator which is effective to continue the actuation of the microvalve. (a) providing an initial constant voltage (80, 82) from the controller (154, 184, 212) to the thermal actuator which is effective to actuate the microvalve; and (b) providing a pulsed voltage (84, 86, 88, 90) from the controller (154, 184, 212) to the thermal actuator which is effective to continue the actuation of the microvalve.
An article of apparel comprising: a dynamic padding system, the dynamic padding system including a pad, a spool, and a filament; wherein the filament is wound around the spool and extends through the pad; wherein the spool is configured to reversibly wind the filament from a first length within the pad to a second length within the pad; wherein the dynamic padding system is configured to reversibly change from a first state to a second state, the first state being associated with the first length of filament within the pad and the second state being associated with the second length of filament within the pad; the first state being associated with a first stiffness, the second state being associate with a second stiffness, the second stiffness being different from the first stiffness.
Multiple clutch for a motor vehicle, in particular for a hybrid drive of a motor vehicle, having at least one first, one second and one third separating clutch (K1, K2, K0), wherein the first separating clutch is provided for coupling or decoupling a first transmission input shaft with a drive (4 or 5), in particular with an internal combustion engine and/or an electric machine, and the second separating clutch is provided for coupling or decoupling a second transmission input shaft with a drive (4 or 5), in particular with an internal combustion engine and/or with an electric machine, wherein the first and second clutches (K1, K2) are configured as a disk clutch and have an inner (6, 7) and outer disc carrier (8a, 8b), wherein the third separating clutch is provided for coupling or decoupling the outer disc carrier (8a, 8b) of the first and second separating clutches (K1, K2) with a drive (4 or 5), in particular with an internal combustion engine and/or an electric machine, wherein the third separating clutch is configured as a multi-plate clutch and an inner and outer disc carrier, and wherein the outer disc carrier (8a, 8b, 8c) of the first, the second and the third separating clutches (K1, K2, K0) is configured as a common outer disc carrier for bearing and/or guiding the outer clutch discs (10, 11, 12) of the first, second and third separating clutches (K1, K2, K0), characterized in that the first, second and third separating clutches (K1, K2, K0) are arranged essentially one behind the other, wherein the middle separating clutch, in particular the first separating clutch, can be actuated by an actuating piston that is at least partially borne and/or guided within of the outer disc carrier of an adjacent separating clutch, in particular of the second separating clutch, and that the actuating piston has a double bearing so that a rotary motion acting on the actuating piston through the first and second clutches (K1, K2) applied are decoupled from each other.
Device for handling fragments of a broken needle, with a container for receipt of the fragments of the broken needle, wherein the container comprises a main body having a topside that limits a reception space together with a cover configured to cover the topside of the main body, wherein a retaining magnet is arranged on the main body, the magnetic field thereof is configured to retain the fragments on the topside of the main body, characterized in that a camera held on the device is configured to capture an image of the fragments retained at the topside of the main body for documentation and/or evaluation and that the processor unit is configured to transmit the captured image to a central computing unit. with a container for receipt of the fragments of the broken needle, wherein the container comprises a main body having a topside that limits a reception space together with a cover configured to cover the topside of the main body, wherein a retaining magnet is arranged on the main body, the magnetic field thereof is configured to retain the fragments on the topside of the main body, characterized in that a camera held on the device is configured to capture an image of the fragments retained at the topside of the main body for documentation and/or evaluation and that the processor unit is configured to transmit the captured image to a central computing unit.
Connection device for connecting an arm and a windscreen wiper, said device comprising a connection element comprising a connection cavity, said connection cavity comprising a transverse shaft designed to cooperate with an end of the actuation arm in order to articulate the windscreen wiper to said actuation arm, characterized in that one end of the connection cavity comprises an asymmetric shape in a sagittal plane of the windscreen wiper, said asymmetric shape forming a single upper abutment wall cooperating with a transverse protuberance of a tongue of the end of the actuation arm in order to limit the pivoting of the wiper about the actuation arm.
A pneumatic tire comprising two sidewalls, two annular bead portions each having a bead core, a carcass extending between the bead portions through the respective sidewall of the tire, and a tread, wherein each sidewall has an upper sidewall portion and a lower sidewall which are separated by a point of maximum axial width of the tire, wherein the lower sidewall portion includes a first concave portion located between a radially outward end of a bead apex and the point of maximum width of the tire, when measured on an unmounted, uninflated tire in a new condition, characterized in that the first concave portion has a radius (R 4) in a range of from 5 cm to 15 cm; and wherein the tire has a second concave portion located in the upper sidewall portion of the tire, the second concave portion having a radius (R 1) in a range of from 7.5 cm to 12.5 cm.
A tool body for a shell end mill, the tool body comprising: at least one spiral-shaped chip guiding groove arranged on a circumference of the tool body for chip dissipation; and at least two receptacles for indexable cutting inserts arranged at the at least one chip-guiding groove, wherein each receptacle comprises a base surface comprising a bore for receiving an indexable cutting insert fastening screw and at least one first abutment surface located adjacent to the base surface, the first abutment surface being perpendicular to the base surface, wherein the transition between the base surface and the first abutment surface is a groove, characterized in that at least one coolant outlet opening is arranged for cooling of a machining process on the end face of the tool body. at least one spiral-shaped chip guiding groove arranged on a circumference of the tool body for chip dissipation; and at least two receptacles for indexable cutting inserts arranged at the at least one chip-guiding groove, wherein each receptacle comprises a base surface comprising a bore for receiving an indexable cutting insert fastening screw and at least one first abutment surface located adjacent to the base surface, the first abutment surface being perpendicular to the base surface, wherein the transition between the base surface and the first abutment surface is a groove, characterized in that at least one coolant outlet opening is arranged for cooling of a machining process on the end face of the tool body.
A method of message acknowledgement performed by a user equipment, UE, of a wireless communication network, the method comprising: establishing, while the UE is in an active radio resource control, RRC, connected mode and prior to entering an uplink-enhanced idle mode, one or more idle-mode uplink air interface resources for communicating with a base station, BS, of the wireless communication network during the uplink-enhanced idle mode of the UE; establishing a UE-specific identifier with the BS; entering the uplink-enhanced idle mode; transmitting a plurality of uplink messages to the BS: during the uplink-enhanced idle mode; through at least one of the one or more idle-mode uplink air interface resources established with the BS; and using the UE-specific identifier; and following the transmitting the plurality of uplink messages, receiving a group acknowledgment from the BS indicating a success or failure of reception by the BS of each of the uplink messages. establishing, while the UE is in an active radio resource control, RRC, connected mode and prior to entering an uplink-enhanced idle mode, one or more idle-mode uplink air interface resources for communicating with a base station, BS, of the wireless communication network during the uplink-enhanced idle mode of the UE; establishing a UE-specific identifier with the BS; entering the uplink-enhanced idle mode; transmitting a plurality of uplink messages to the BS: during the uplink-enhanced idle mode; through at least one of the one or more idle-mode uplink air interface resources established with the BS; and using the UE-specific identifier; and during the uplink-enhanced idle mode; through at least one of the one or more idle-mode uplink air interface resources established with the BS; and using the UE-specific identifier; and following the transmitting the plurality of uplink messages, receiving a group acknowledgment from the BS indicating a success or failure of reception by the BS of each of the uplink messages.
A pharmaceutical composition for use in preventing or treating stroke or neurodegenerative diseases comprising an extract complex of Pueraria lobata and Scutellaria baicalensis as an active ingredient wherein the neurodegenerative disease is selected from a group consisting of dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, Pick's disease and Creutzfeld-Jacob disease, wherein the extract complex of Pueraria lobata and Scutellaria baicalensis is extracted from a mixture containing 65-95 wt% of Pueraria lobata and 5-35 wt% of Scutellaria baicalensis.
A method of graphically previewing changes to hardware driver parameters in a graphical computing environment, using a preview application, said method comprising: forcing an executable graphics application to load hardware driver parameter settings; drawing a first preview region using said executable graphics application; receiving user input indicating changes to said hardware driver parameter settings from initial settings to changed settings by way of an user interface presented by said preview application; altering said hardware driver parameter settings to reflect said changed settings; creating a further instance of said executable graphics application, and forcing said further instance of said executable graphics application to load said hardware parameter settings as changed; drawing a second preview region at the location of said first preview region, using said further instance of said executable graphics application, said second preview region reflective of said changed settings making said second preview region visible in place of said first preview region, thereby graphically previewing said changed settings at the location of said first preview region; altering said hardware driver parameter settings to said initial settings after said drawing said second preview region, so that new instances of executable graphics applications, created after said hardware driver parameters have been altered to said initial settings, are unaffected by said changes. forcing an executable graphics application to load hardware driver parameter settings; drawing a first preview region using said executable graphics application; receiving user input indicating changes to said hardware driver parameter settings from initial settings to changed settings by way of an user interface presented by said preview application; altering said hardware driver parameter settings to reflect said changed settings; creating a further instance of said executable graphics application, and forcing said further instance of said executable graphics application to load said hardware parameter settings as changed; drawing a second preview region at the location of said first preview region, using said further instance of said executable graphics application, said second preview region reflective of said changed settings making said second preview region visible in place of said first preview region, thereby graphically previewing said changed settings at the location of said first preview region; altering said hardware driver parameter settings to said initial settings after said drawing said second preview region, so that new instances of executable graphics applications, created after said hardware driver parameters have been altered to said initial settings, are unaffected by said changes.
A nitride-based semiconductor light-emitting device, comprising: an n-electrode; a nitride-based semiconductor multilayer structure including an n-type GaN based semiconductor layer, a GaN based active layer, and a p-type GaN based semiconductor layer; and a p-electrode arranged on the p-type GaN based semiconductor layer, wherein the p-electrode includes an Mg layer which is in contact with the surface of the p-type GaN based semiconductor layer and an Ag layer which is provided on the Mg layer, characterized in that a surface of the p-type GaN based semiconductor layer being an m -plane, and a concentration of N in the Mg layer is lower than a concentration of Ga in the Mg layer. an n-electrode; a nitride-based semiconductor multilayer structure including an n-type GaN based semiconductor layer, a GaN based active layer, and a p-type GaN based semiconductor layer; and a p-electrode arranged on the p-type GaN based semiconductor layer, wherein the p-electrode includes an Mg layer which is in contact with the surface of the p-type GaN based semiconductor layer and an Ag layer which is provided on the Mg layer, characterized in that a surface of the p-type GaN based semiconductor layer being an m -plane, and a concentration of N in the Mg layer is lower than a concentration of Ga in the Mg layer.
A computer-implemented method for managing applications on a mobile device (102; 302), comprising: receiving context data related to the mobile device; assigning a situational utility score to one or more applications available in an application repository by analyzing the context data and tags associated with the one or more applications to determine which applications are relevant to a user or to the mobile device; responsive to determining that the situational utility score for an application is greater than a threshold value, sending an instruction to the mobile device to automatically install the application, or display a prompt on the mobile device to request permission to install the application as a temporary application; and responsive to determining that the situational utility score for an application has decreased to be under a certain minimum threshold value, automatically uninstalling the application or displaying a prompt to uninstall the application. receiving context data related to the mobile device; assigning a situational utility score to one or more applications available in an application repository by analyzing the context data and tags associated with the one or more applications to determine which applications are relevant to a user or to the mobile device; responsive to determining that the situational utility score for an application is greater than a threshold value, sending an instruction to the mobile device to automatically install the application, or display a prompt on the mobile device to request permission to install the application as a temporary application; and responsive to determining that the situational utility score for an application has decreased to be under a certain minimum threshold value, automatically uninstalling the application or displaying a prompt to uninstall the application.