mhurhangee/ep-ind-claims huggingface dataset:
A ROR1 specific multi-chain Chimeric Antigen Receptor (mcCAR) comprising: - a transmembrane polypeptide from the alpha chain of high-affinity IgE receptor (FcεRI) fused to an extracellular ROR1 ligand binding domain; - a second transmembrane polypeptide from the gamma chain of FcεRI fused to a signal transducing domain from CD3zeta; - a third transmembrane polypeptide from the beta chain of FcεRI comprising a co-stimulatory domain from 4-1BB, wherein said ROR1 ligand binding domain fused to said alpha chain of FcεRI is a single-chain variable fragment (scFv) comprising heavy (V H) and light (V L) chains conferring specificity to ROR1, wherein said extra cellular ligand binding-domain comprises: - a VH chain comprising the CDRs from the mouse monoclonal antibody D10 of SEQ ID NO.: 29 (CDR-H1), SEQ ID NO.: 30 (CDR-H2) and SEQ ID NO.: 31 (CDR-H3), and a VL chain comprising the CDRs from the mouse monoclonal antibody D10 of NO.: 33 (CDR-L1), SEQ ID NO.: 34 (CDR-L2) and SEQ ID NO: 35 (CDR-L3); or - a VH chain comprising the CDRs from the mouse monoclonal antibody 2A2 of SEQ ID NO.: 13 (CDR-H1), SEQ ID NO.: 14 (CDR-H2) and SEQ ID NO.:15 (CDR-H3) and a VL chain comprising the CDRs from the mouse monoclonal antibody 2A2 of SEQ ID NO.: 17 (CDR-L1), SEQ ID NO: 18 (CDR-L2) and SEQ ID NO: 19 (CDR-L3). - a transmembrane polypeptide from the alpha chain of high-affinity IgE receptor (FcεRI) fused to an extracellular ROR1 ligand binding domain; - a second transmembrane polypeptide from the gamma chain of FcεRI fused to a signal transducing domain from CD3zeta; - a third transmembrane polypeptide from the beta chain of FcεRI comprising a co-stimulatory domain from 4-1BB, - a VH chain comprising the CDRs from the mouse monoclonal antibody D10 of SEQ ID NO.: 29 (CDR-H1), SEQ ID NO.: 30 (CDR-H2) and SEQ ID NO.: 31 (CDR-H3), and a VL chain comprising the CDRs from the mouse monoclonal antibody D10 of NO.: 33 (CDR-L1), SEQ ID NO.: 34 (CDR-L2) and SEQ ID NO: 35 (CDR-L3); or - a VH chain comprising the CDRs from the mouse monoclonal antibody 2A2 of SEQ ID NO.: 13 (CDR-H1), SEQ ID NO.: 14 (CDR-H2) and SEQ ID NO.:15 (CDR-H3) and a VL chain comprising the CDRs from the mouse monoclonal antibody 2A2 of SEQ ID NO.: 17 (CDR-L1), SEQ ID NO: 18 (CDR-L2) and SEQ ID NO: 19 (CDR-L3).
A layered nonwoven fabric comprising an upper layer consisting of a first nonwoven fabric and a lower layer consisting of a second nonwoven fabric, wherein the first nonwoven fabric and second nonwoven fabric are each composed of extendable fibers, and some of the extendable fibers of the first nonwoven fabric are tangled with some of the extendable fibers of the second nonwoven fabric, the layered nonwoven fabric has a first surface on the first nonwoven fabric side with a plurality of protrusions and recesses and a second surface on the second nonwoven fabric side, the protrusions on the first surface have a higher basis weight than the recesses on the first surface, and the protrusions on the first surface have a lower fiber density than the recesses on the first surface.
An environmental control system, comprising: an inlet line configured to receive a medium flowing from a low-pressure location of an engine to a chamber; a plurality of heat exchangers (110,120) configured to receive the medium from the inlet line; a valve located upstream from the plurality of heat exchangers (110,120), the valve configured to divide in parallel the medium across at least a first heat exchanger and a second heat exchanger of the plurality of heat exchangers; and characterized by further comprising a recirculation air system configured to supply a recirculation air from the chamber to the inlet line upstream of the plurality of heat exchangers (110,120). an inlet line configured to receive a medium flowing from a low-pressure location of an engine to a chamber; a plurality of heat exchangers (110,120) configured to receive the medium from the inlet line; a valve located upstream from the plurality of heat exchangers (110,120), the valve configured to divide in parallel the medium across at least a first heat exchanger and a second heat exchanger of the plurality of heat exchangers; and characterized by further comprising a recirculation air system configured to supply a recirculation air from the chamber to the inlet line upstream of the plurality of heat exchangers (110,120).
A system comprising a broadcast receiving device and a renewable energy source, wherein the broadcast receiving device is a television comprising a display that provides the program to be watched, the broadcast receiving device being energized by the renewable energy source and comprising at least one receiver receiving a broadcast to be received, a recording unit recording a broadcast to be recorded, and a control unit, wherein the control unit is provided for controlling the operation of the recording unit according to an energy amount supplied by the renewable energy source, wherein the control unit causes the recording unit to record the program being watched when the energy amount supplied by the renewable energy source drops below a limit energy amount predetermined by the producer of the broadcast receiving device, and wherein the control unit switches off the display as well upon causing the recording unit to record the program being watched according to the energy amount supplied by the renewable energy source.
Multiple-use sensorassembly for body fluids, the sensor assembly comprising: - a measurement chamber extending in an axial direction from an inlet to an outlet, the measurement chamber having a transverse cross-section with side walls (5, 6) defining a chamber width in a horizontal direction, and with top and bottom walls (7, 8) defining a chamber height in a vertical direction, each of the side walls (5, 6), top wall and bottom wall having a respective wall wettability for aqueous solutions; - a first sensor (10a-h) adapted to measure a first parameter of body fluids, the first sensor having a first sensor surface (11a-h) exposed to the inside of the measurement chamber at a first axial position, the first sensor surface having a first wettability for aqueous solutions; and - a second sensor adapted to measure a second parameter of body fluids, the second sensor having a second sensor surface exposed to the inside of the measurement chamber at a second axial position upstream or downstream from the first axial position, characterised in the second sensor surface having a second wettability for aqueous solutions higher than the first wettability; wherein at the second axial position the chamber width exceeds the width of the second sensor surface, and wherein the measurement chamber at the second axial position has a widening in a horizontal direction as compared to the first axial position. - a measurement chamber extending in an axial direction from an inlet to an outlet, the measurement chamber having a transverse cross-section with side walls (5, 6) defining a chamber width in a horizontal direction, and with top and bottom walls (7, 8) defining a chamber height in a vertical direction, each of the side walls (5, 6), top wall and bottom wall having a respective wall wettability for aqueous solutions; - a first sensor (10a-h) adapted to measure a first parameter of body fluids, the first sensor having a first sensor surface (11a-h) exposed to the inside of the measurement chamber at a first axial position, the first sensor surface having a first wettability for aqueous solutions; and - a second sensor adapted to measure a second parameter of body fluids, the second sensor having a second sensor surface exposed to the inside of the measurement chamber at a second axial position upstream or downstream from the first axial position, characterised in the second sensor surface having a second wettability for aqueous solutions higher than the first wettability; wherein at the second axial position the chamber width exceeds the width of the second sensor surface, and wherein the measurement chamber at the second axial position has a widening in a horizontal direction as compared to the first axial position.
A method for producing refrigeration comprising: compressing a composition including a lubricant and a refrigerant comprising, preferably, consisting essentially of, trans-chloro-3,3,3,-trifluoropropene (1233zd); wherein the compressing occurs within a centrifugal chiller system. compressing a composition including a lubricant and a refrigerant comprising, preferably, consisting essentially of, trans-chloro-3,3,3,-trifluoropropene (1233zd); wherein the compressing occurs within a centrifugal chiller system.
A surgical device, comprising: a first clamping member (1005, 1105); a second clamping member (1010, 1110); an electric motor configured to drive at least one of the first or second clamping members toward a predetermined tissue gap (1020, 1120) between the first and second clamping members, a current sensor configured to measure a current delivered to the electric motor; and a control system configured to monitor a parameter of the electric motor indicative of a clamping force exerted to the tissue by the clamping members and to control the electric motor, based on the monitored parameter, to limit the clamping force to a predetermined maximum limit, characterized in that the parameter is a net motor current, and the control system is configured to determine the net motor current by the steps of: measuring, prior to clamping the first and second clamping members on tissue, a first current delivered to the electric motor due to frictional losses associated with moving the clamping members; and subtracting the first current from a measured second current delivered to the electric motor during clamping of the first and second clamping members (1005, 1105, 1010, 1110) on the tissue. a first clamping member (1005, 1105); a second clamping member (1010, 1110); an electric motor configured to drive at least one of the first or second clamping members toward a predetermined tissue gap (1020, 1120) between the first and second clamping members, a current sensor configured to measure a current delivered to the electric motor; and a control system configured to monitor a parameter of the electric motor indicative of a clamping force exerted to the tissue by the clamping members and to control the electric motor, based on the monitored parameter, to limit the clamping force to a predetermined maximum limit, characterized in that the parameter is a net motor current, and the control system is configured to determine the net motor current by the steps of: measuring, prior to clamping the first and second clamping members on tissue, a first current delivered to the electric motor due to frictional losses associated with moving the clamping members; and subtracting the first current from a measured second current delivered to the electric motor during clamping of the first and second clamping members (1005, 1105, 1010, 1110) on the tissue. measuring, prior to clamping the first and second clamping members on tissue, a first current delivered to the electric motor due to frictional losses associated with moving the clamping members; and subtracting the first current from a measured second current delivered to the electric motor during clamping of the first and second clamping members (1005, 1105, 1010, 1110) on the tissue.
A method for providing at least one tomographic or planar distribution (n(x,y)) of refractive index values in a sample, the sample being located in a sample unit, the sample unit including a container containing a dispersive medium in which said sample is located, the dispersion law of the index of refraction of the medium being known, the method comprising the steps of: - illuminating the sample with electromagnetic radiation; - creating an object wave in a transmission imaging geometry by collecting the electromagnetic radiation that has crossed the sample; - creating a reference wave from the electromagnetic radiation, - producing a plurality of holograms via interference between the reference wave and the object wave, the plurality of holograms being produced by varying the incidence angle of the electromagnetic radiation illuminating the sample; - producing a plurality of digital holograms by acquiring and digitizing said plurality of holograms; - providing a plurality of amplitude-contrast images and/or a plurality of quantitative phase contrast images by numerical reconstruction calculations applied to the plurality of digital holograms; - calculating the at least one tomographic or planar distribution (n(x,y)) of refractive index values in the sample based on the known dispersion law of the index of refraction of the medium and on the plurality of amplitude-contrast images and/or the plurality of quantitative phase contrast images; and wherein the wavelength of said electromagnetic radiation is modified and said plurality of holograms are generated by varying the wavelength of said electromagnetic radiation and the incidence angle of said electromagnetic radiation. - illuminating the sample with electromagnetic radiation; - creating an object wave in a transmission imaging geometry by collecting the electromagnetic radiation that has crossed the sample; - creating a reference wave from the electromagnetic radiation, - producing a plurality of holograms via interference between the reference wave and the object wave, the plurality of holograms being produced by varying the incidence angle of the electromagnetic radiation illuminating the sample; - producing a plurality of digital holograms by acquiring and digitizing said plurality of holograms; - providing a plurality of amplitude-contrast images and/or a plurality of quantitative phase contrast images by numerical reconstruction calculations applied to the plurality of digital holograms; - calculating the at least one tomographic or planar distribution (n(x,y)) of refractive index values in the sample based on the known dispersion law of the index of refraction of the medium and on the plurality of amplitude-contrast images and/or the plurality of quantitative phase contrast images; and
A system comprising an operating table for supporting a patient, the operating table having a base and a table top, the table top comprising: - at least three elements (20 1 -20 6) and - at least two interface joints (40 1 - 40 3), each interface joint serving as a movable connection between two adjacent elements, the operating table further comprising - a controller arranged to control each interface joint (40 1 - 40 3) to actuate a movement of at least one adjacent element relative to the other; - a light emitting arrangement being associated with each interface joint (40 1 - 40 3) and adapted to display light in a pattern that is visible on at least one end of each interface joint at a lateral edge of the table top, a characteristic of the pattern displayed by the light emitting arrangement being visibly unique to the associated interface joint such that the interface joints (40 1 - 40 3) are visually distinguishable from one another. - at least three elements (20 1 -20 6) and - at least two interface joints (40 1 - 40 3), each interface joint serving as a movable connection between two adjacent elements, the operating table further comprising - a controller arranged to control each interface joint (40 1 - 40 3) to actuate a movement of at least one adjacent element relative to the other; - a light emitting arrangement being associated with each interface joint (40 1 - 40 3) and adapted to display light in a pattern that is visible on at least one end of each interface joint at a lateral edge of the table top, a characteristic of the pattern displayed by the light emitting arrangement being visibly unique to the associated interface joint such that the interface joints (40 1 - 40 3) are visually distinguishable from one another.
A system comprising: a computing cloud comprising at least one data storage unit and at least one processing unit; wherein the computing cloud is configured to connect to a client, monitor traffic associated with the client, select an operational mode defining a state in which the client is operating from a list of known operational modes, identify a traffic condition of the monitored traffic, compare the identified traffic condition of the monitored traffic with an anticipated traffic pattern associated with the selected operational mode to form a comparison, and determine if a security threat is indicated based on the comparison; wherein the computing cloud is configured to identify the traffic condition of the monitored traffic based on a number of factors including a number of destination Internet Protocol addresses for the traffic, an amount of network bandwidth used, and ports over which the traffic is being transmitted. a computing cloud comprising at least one data storage unit and at least one processing unit; wherein the computing cloud is configured to connect to a client, monitor traffic associated with the client, select an operational mode defining a state in which the client is operating from a list of known operational modes, identify a traffic condition of the monitored traffic, compare the identified traffic condition of the monitored traffic with an anticipated traffic pattern associated with the selected operational mode to form a comparison, and determine if a security threat is indicated based on the comparison; wherein the computing cloud is configured to identify the traffic condition of the monitored traffic based on a number of factors including a number of destination Internet Protocol addresses for the traffic, an amount of network bandwidth used, and ports over which the traffic is being transmitted.
A pressure relief system including a pressure relief assembly and a duct, the duct having an interior volume defined by a sidewall and a relief aperture defined through the sidewall of the duct, the pressure relief system comprising: a cover configured to seal the relief aperture when positioned in a closed configuration and to expose the relief aperture to an external environment when positioned in an open configuration; a first chamber at least partially defined by the sidewall and having a first volume fluidly coupled to the interior volume of the duct through a first orifice; a second chamber at least partially defined by the sidewall and having a second volume fluidly coupled to the interior volume of the duct through a second orifice, the second orifice having a larger area than an area of the first orifice; and a piston coupled to the cover, positioned between the first chamber and the second chamber and defining a wall of the first chamber and the second chamber, and configured to change the first volume and the second volume in response to a change in pressure in at least the first chamber or the second chamber, the piston also configured to move the cover between the open and the closed configuration. a cover configured to seal the relief aperture when positioned in a closed configuration and to expose the relief aperture to an external environment when positioned in an open configuration; a first chamber at least partially defined by the sidewall and having a first volume fluidly coupled to the interior volume of the duct through a first orifice; a second chamber at least partially defined by the sidewall and having a second volume fluidly coupled to the interior volume of the duct through a second orifice, the second orifice having a larger area than an area of the first orifice; and a piston coupled to the cover, positioned between the first chamber and the second chamber and defining a wall of the first chamber and the second chamber, and configured to change the first volume and the second volume in response to a change in pressure in at least the first chamber or the second chamber, the piston also configured to move the cover between the open and the closed configuration.
A subintimal recanalization catheter (600, 900, 1000), comprising: an elongate shaft including a first tubular member and a penetration member slidably disposed in a lumen of the first tubular member; the first tubular member including a distal nose at the distal end of the elongate shaft; the penetration member including a distal portion having a distal tip positioned proximal of the distal nose of the first tubular member; and the distal nose of the first tubular member including a ramp and a guide wire lumen extending through the distal nose of the first tubular member; characterized in that the catheter is configured such that longitudinal movement of the penetration member relative to the first tubular member causes the penetration member to contact the ramp to direct the distal tip of the penetration member away from the first tubular member while a guide wire configured to extend through a lumen of the penetration member and through the lumen of the distal nose of the first tubular member is routed through the lumen of the distal nose of the first tubular member, and the distal portion of the penetration member is free to deflect away from a central axis of the first tubular member. an elongate shaft including a first tubular member and a penetration member slidably disposed in a lumen of the first tubular member; the first tubular member including a distal nose at the distal end of the elongate shaft; the penetration member including a distal portion having a distal tip positioned proximal of the distal nose of the first tubular member; and the distal nose of the first tubular member including a ramp and a guide wire lumen extending through the distal nose of the first tubular member; characterized in that the catheter is configured such that longitudinal movement of the penetration member relative to the first tubular member causes the penetration member to contact the ramp to direct the distal tip of the penetration member away from the first tubular member while a guide wire configured to extend through a lumen of the penetration member and through the lumen of the distal nose of the first tubular member is routed through the lumen of the distal nose of the first tubular member, and the distal portion of the penetration member is free to deflect away from a central axis of the first tubular member.