A method of detecting at least one target nucleic acid, the method comprising: (a) providing a sample comprising or suspected of comprising said target nucleic acid; (b) providing at least one set of two or more capture probes capable of hybridizing to said target nucleic acid; (c) providing a signal generating multimer capable of hybridizing to said set of two or more capture probes, wherein said signal generating multimer comprises a label probe; (d) providing a signal amplification probe capable of conjugating to said label probe, wherein said signal amplification probe comprises: (i) a biotin molecule which is capable of conjugating to said label probe, an avidin/streptavidin molecule which is capable of binding to said biotin molecule, and additional biotin molecules which are conjugated to Horse Radish Peroxidase, Alkaline Phosphatase, or fluorophores and capable of binding to said avidin/streptavidin molecule; (ii) an HRP, AP, Dinitrophenyl, or fluorophore molecule which is capable of conjugating to said label probe, one or more first antibody which is capable of binding to HRP, AP, DNP, or fluorophore molecule, and one or more second antibody which is conjugated to HRP, Polymer-HRP, AP, Polymer-AP, or fluorophore and capable of binding to said one or more first antibody; or (iii) an HRP molecule which is capable of conjugating to said label probe, a plurality of tyramide-fluorophore molecules or a plurality of tyramide-biotin or tyramide-hapten molecules which are capable of reacting with said HRP molecule, and detection labels which are capable of detecting said tyramide-biotin or tyramide-hapten molecules visually; (e) hybridizing said target nucleic acid to said set of two or more capture probes; (f) capturing the signal generating multimer to said set of two or more capture probes and thereby capturing the signal generating multimer to said target nucleic acid; (g) capturing said signal amplification probe to said label probe and thereby capturing the signal amplification probe to said signal generating multimer; and (h) detecting the presence, absence, or amount of the signal generated by said signal amplification probe. (a) providing a sample comprising or suspected of comprising said target nucleic acid; (b) providing at least one set of two or more capture probes capable of hybridizing to said target nucleic acid; (c) providing a signal generating multimer capable of hybridizing to said set of two or more capture probes, wherein said signal generating multimer comprises a label probe; (d) providing a signal amplification probe capable of conjugating to said label probe, wherein said signal amplification probe comprises: (i) a biotin molecule which is capable of conjugating to said label probe, an avidin/streptavidin molecule which is capable of binding to said biotin molecule, and additional biotin molecules which are conjugated to Horse Radish Peroxidase, Alkaline Phosphatase, or fluorophores and capable of binding to said avidin/streptavidin molecule; (ii) an HRP, AP, Dinitrophenyl, or fluorophore molecule which is capable of conjugating to said label probe, one or more first antibody which is capable of binding to HRP, AP, DNP, or fluorophore molecule, and one or more second antibody which is conjugated to HRP, Polymer-HRP, AP, Polymer-AP, or fluorophore and capable of binding to said one or more first antibody; or (iii) an HRP molecule which is capable of conjugating to said label probe, a plurality of tyramide-fluorophore molecules or a plurality of tyramide-biotin or tyramide-hapten molecules which are capable of reacting with said HRP molecule, and detection labels which are capable of detecting said tyramide-biotin or tyramide-hapten molecules visually; (i) a biotin molecule which is capable of conjugating to said label probe, an avidin/streptavidin molecule which is capable of binding to said biotin molecule, and additional biotin molecules which are conjugated to Horse Radish Peroxidase, Alkaline Phosphatase, or fluorophores and capable of binding to said avidin/streptavidin molecule; (ii) an HRP, AP, Dinitrophenyl, or fluorophore molecule which is capable of conjugating to said label probe, one or more first antibody which is capable of binding to HRP, AP, DNP, or fluorophore molecule, and one or more second antibody which is conjugated to HRP, Polymer-HRP, AP, Polymer-AP, or fluorophore and capable of binding to said one or more first antibody; or (iii) an HRP molecule which is capable of conjugating to said label probe, a plurality of tyramide-fluorophore molecules or a plurality of tyramide-biotin or tyramide-hapten molecules which are capable of reacting with said HRP molecule, and detection labels which are capable of detecting said tyramide-biotin or tyramide-hapten molecules visually; (e) hybridizing said target nucleic acid to said set of two or more capture probes; (f) capturing the signal generating multimer to said set of two or more capture probes and thereby capturing the signal generating multimer to said target nucleic acid; (g) capturing said signal amplification probe to said label probe and thereby capturing the signal amplification probe to said signal generating multimer; and (h) detecting the presence, absence, or amount of the signal generated by said signal amplification probe.