An antibody-drug-conjugate of the following formula: Ab-(L-D)n or a pharmaceutically acceptable salt thereof, wherein Ab is a [Target] antibody or an antigen antibody, or a [Target] binding fragment thereof or an antigen binding fragment thereof; L is a linker of the following formula: wherein L 2 is (C 4 -C 10)cycloalkyl-carbonyl, (C 2 -C 6)alkyl, or (C 2 -C 6)alkyl-carbonyl, W is an amino acid unit; w is an integer comprised between 0 and 5; Y is PAB-carbonyl with PAB being y is 0 or 1; the asterisk indicates the point of attachment to D; the wavy line indicates the point of attachment to Ab; D is a drug moiety of the following formula: wherein: R 1 is H or OH; R 2 is a group: (C 1 -C 6)alkyl, COOH, COO-((C 1 -C 6)alkyl) or thiazolyl; R 3 is H or a (C 1 -C 6)alkyl group; A is: - a group of formula -Het-Alk- wherein Alk is a (C 1 -C 8)alkanediyl group and is linked to NR 3, and Het is a heterocycle optionally substituted by a (C 1 -C 6)alkyl group and containing at least one nitrogen atom, said nitrogen atom being linked to L, or - a group of formula -A a -Ab- wherein A a is linked to L and is O or NR 9 with R 9 being H or (C 1 -C 6)alkyl and A b is linked to NR 3 and is: ▪ a (C 1 -C 8)alkanediyl group, ▪ a -(CH 2 CH 2 X 1) a1 (CH 2 CH 2 X 2) a2 (CH 2 CH 2 X 3) a3 (CH 2 CH 2 X 4) a4 CH 2 CH 2 -group with X 1, X 2, X 3 and X 4 each independently of one another representing O or NR 8; a1, a2, a3 and a4 each independently of one another representing 0 or 1; and R 8 representing H or a (C 1 -C 6)alkyl group, ▪ an aryl-(C 1 -C 8)alkanediyl or heterocycle-(C 1 -C 8)alkanediyl group, said group being optionally substituted by a (C 1 -C 6)alkyl group, the aryl or heterocycle moiety being linked to A a and the (C 1 -C 8)alkanediyl moiety being linked to NR 3; the wavy line indicates the point of attachment to L; and n is 1 to 12. R 1 is H or OH; R 2 is a group: (C 1 -C 6)alkyl, COOH, COO-((C 1 -C 6)alkyl) or thiazolyl; R 3 is H or a (C 1 -C 6)alkyl group; A is: - a group of formula -Het-Alk- wherein Alk is a (C 1 -C 8)alkanediyl group and is linked to NR 3, and Het is a heterocycle optionally substituted by a (C 1 -C 6)alkyl group and containing at least one nitrogen atom, said nitrogen atom being linked to L, or - a group of formula -A a -Ab- wherein A a is linked to L and is O or NR 9 with R 9 being H or (C 1 -C 6)alkyl and A b is linked to NR 3 and is: ▪ a (C 1 -C 8)alkanediyl group, ▪ a -(CH 2 CH 2 X 1) a1 (CH 2 CH 2 X 2) a2 (CH 2 CH 2 X 3) a3 (CH 2 CH 2 X 4) a4 CH 2 CH 2 -group with X 1, X 2, X 3 and X 4 each independently of one another representing O or NR 8; a1, a2, a3 and a4 each independently of one another representing 0 or 1; and R 8 representing H or a (C 1 -C 6)alkyl group, ▪ an aryl-(C 1 -C 8)alkanediyl or heterocycle-(C 1 -C 8)alkanediyl group, said group being optionally substituted by a (C 1 -C 6)alkyl group, the aryl or heterocycle moiety being linked to A a and the (C 1 -C 8)alkanediyl moiety being linked to NR 3; - a group of formula -Het-Alk- wherein Alk is a (C 1 -C 8)alkanediyl group and is linked to NR 3, and Het is a heterocycle optionally substituted by a (C 1 -C 6)alkyl group and containing at least one nitrogen atom, said nitrogen atom being linked to L, or - a group of formula -A a -Ab- wherein A a is linked to L and is O or NR 9 with R 9 being H or (C 1 -C 6)alkyl and A b is linked to NR 3 and is: ▪ a (C 1 -C 8)alkanediyl group, ▪ a -(CH 2 CH 2 X 1) a1 (CH 2 CH 2 X 2) a2 (CH 2 CH 2 X 3) a3 (CH 2 CH 2 X 4) a4 CH 2 CH 2 -group with X 1, X 2, X 3 and X 4 each independently of one another representing O or NR 8; a1, a2, a3 and a4 each independently of one another representing 0 or 1; and R 8 representing H or a (C 1 -C 6)alkyl group, ▪ an aryl-(C 1 -C 8)alkanediyl or heterocycle-(C 1 -C 8)alkanediyl group, said group being optionally substituted by a (C 1 -C 6)alkyl group, the aryl or heterocycle moiety being linked to A a and the (C 1 -C 8)alkanediyl moiety being linked to NR 3; ▪ a (C 1 -C 8)alkanediyl group, ▪ a -(CH 2 CH 2 X 1) a1 (CH 2 CH 2 X 2) a2 (CH 2 CH 2 X 3) a3 (CH 2 CH 2 X 4) a4 CH 2 CH 2 -group with X 1, X 2, X 3 and X 4 each independently of one another representing O or NR 8; a1, a2, a3 and a4 each independently of one another representing 0 or 1; and R 8 representing H or a (C 1 -C 6)alkyl group, ▪ an aryl-(C 1 -C 8)alkanediyl or heterocycle-(C 1 -C 8)alkanediyl group, said group being optionally substituted by a (C 1 -C 6)alkyl group, the aryl or heterocycle moiety being linked to A a and the (C 1 -C 8)alkanediyl moiety being linked to NR 3; the wavy line indicates the point of attachment to L; and n is 1 to 12.