A composition for use in treating skin diseases and skin conditions in a human patient in need of such treatment by topical dermatological application of a therapeutically effective amount of said composition comprising a compound according to Formula I, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystal forms, its individual tautomers or a pharmaceutically acceptable salt thereof, wherein R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H; C 1-10 alkyl; an aromatic or non-aromatic 5- to 10-membered monocyclic or bicyclic heterocycle containing at least one heteroatom selected from O or N or S or combinations thereof; or a C 6-10 monocyclic or bicyclic aryl group; and R is a C 1-10 alkyl group optionally substituted by amino groups, aryl groups and halogen atoms, wherein one methylene group of the alkyl chain can be replaced by carbonyl, -NH-, carboxyl, amide, -S- or -O-; an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic heterocycle containing at least one heteroatom selected from O or N or S or combinations thereof, wherein the heterocycle is optionally substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), -C O(C 1-6 alkyl), - NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), -S(C 1-6 alkyl) groups; or a C 6-10 monocyclic or bicyclic aryl group optionally substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl),-OC (C I - 6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl) or -S(C 1-6 alkyl) groups; wherein said skin diseases and skin conditions are selected from: rosacea, sunburn, chronic sun damage, discreet erythemas, psoriasis, atopic dermatitis, menopause-associated hot flashes, hot flashes resulting from orchiectomy, atopic dermatitis, photoaging, seborrheic dermatitis, acne, allergic dermatitis, and irritant dermatitis. R 1 is H or C 1-3 alkyl; R 2 is H or C 1-3 alkyl; R 3 is H; C 1-10 alkyl; an aromatic or non-aromatic 5- to 10-membered monocyclic or bicyclic heterocycle containing at least one heteroatom selected from O or N or S or combinations thereof; or a C 6-10 monocyclic or bicyclic aryl group; and R is a C 1-10 alkyl group optionally substituted by amino groups, aryl groups and halogen atoms, wherein one methylene group of the alkyl chain can be replaced by carbonyl, -NH-, carboxyl, amide, -S- or -O-; an aromatic or non-aromatic 5 to 10 membered monocyclic or bicyclic heterocycle containing at least one heteroatom selected from O or N or S or combinations thereof, wherein the heterocycle is optionally substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl), -OC (C 1-6 alkyl), -C O(C 1-6 alkyl), - NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl), -S(C 1-6 alkyl) groups; or a C 6-10 monocyclic or bicyclic aryl group optionally substituted by C 1-6 alkyl, amino, halogen, -O(C 1-6 alkyl),-OC (C I - 6 alkyl), -C O(C 1-6 alkyl), -NHC (C 1-6 alkyl), -C NH(C 1-6 alkyl) or -S(C 1-6 alkyl) groups; wherein said skin diseases and skin conditions are selected from: rosacea, sunburn, chronic sun damage, discreet erythemas, psoriasis, atopic dermatitis, menopause-associated hot flashes, hot flashes resulting from orchiectomy, atopic dermatitis, photoaging, seborrheic dermatitis, acne, allergic dermatitis, and irritant dermatitis.