A power generation system comprising: a first heating fluid circuit thermally coupled to a first plurality of heat sources (102a-102g) from a first plurality of sub-units of a petrochemical refining system, the first plurality of sub-units comprising a hydrocracking plant; a second heating fluid circuit thermally coupled to a second plurality of heat sources (103a-103c) from a second plurality of sub-units of the petrochemical refining system, the second plurality of sub-units comprising a diesel hydrotreating reaction and stripping plant; a third heating fluid circuit thermally coupled to a third plurality of heat sources (105a-105h) of a third plurality of sub-units of the petrochemical refining system, the third plurality of sub-units comprising a CCR plant and a portion of an aromatics plants separation plant; a fourth heating fluid circuit thermally coupled to a fourth plurality of heat sources (107a-107c) of a fourth plurality of sub-units of the petrochemical refining system, the fourth plurality of sub-units comprising a Naphtha hydrotreating plant and a CCR/aromatics plant; a fifth heating fluid circuit thermally coupled to a fifth plurality of heat sources (109a-109c) of a fifth plurality of sub-units of the petrochemical refining system, the fifth plurality of sub-units comprising a para-xylene separation unit; a power generation system that comprises an organic Rankine cycle, the organic Rankine cycle comprising i) a working fluid that is thermally coupled to the first through fifth heating fluid circuits to heat the working fluid, and ii) a expander configured to generate electrical power from the heated working fluid; and a control system configured to actuate a first set of control valves to selectively thermally couple the first heating fluid circuit to at least a portion of the first plurality of heat sources, the control system also configured to actuate a second set of control valves to selectively thermally couple the second heating fluid circuit to at least a portion of the second plurality of heat sources, the control system also configured to actuate a third set of control valves to selectively thermally couple the third heating fluid circuit to at least a portion of the third plurality of heat sources, the control system also configured to actuate a fourth set of control valves to selectively thermally couple the fourth heating fluid circuit to at least a portion of the fourth plurality of heat sources, and the control system also configured to actuate a fifth set of control valves to selectively thermally couple the fifth heating fluid circuit to at least a portion of the fifth plurality of heat sources. a first heating fluid circuit thermally coupled to a first plurality of heat sources (102a-102g) from a first plurality of sub-units of a petrochemical refining system, the first plurality of sub-units comprising a hydrocracking plant; a second heating fluid circuit thermally coupled to a second plurality of heat sources (103a-103c) from a second plurality of sub-units of the petrochemical refining system, the second plurality of sub-units comprising a diesel hydrotreating reaction and stripping plant; a third heating fluid circuit thermally coupled to a third plurality of heat sources (105a-105h) of a third plurality of sub-units of the petrochemical refining system, the third plurality of sub-units comprising a CCR plant and a portion of an aromatics plants separation plant; a fourth heating fluid circuit thermally coupled to a fourth plurality of heat sources (107a-107c) of a fourth plurality of sub-units of the petrochemical refining system, the fourth plurality of sub-units comprising a Naphtha hydrotreating plant and a CCR/aromatics plant; a fifth heating fluid circuit thermally coupled to a fifth plurality of heat sources (109a-109c) of a fifth plurality of sub-units of the petrochemical refining system, the fifth plurality of sub-units comprising a para-xylene separation unit; a power generation system that comprises an organic Rankine cycle, the organic Rankine cycle comprising i) a working fluid that is thermally coupled to the first through fifth heating fluid circuits to heat the working fluid, and ii) a expander configured to generate electrical power from the heated working fluid; and a control system configured to actuate a first set of control valves to selectively thermally couple the first heating fluid circuit to at least a portion of the first plurality of heat sources, the control system also configured to actuate a second set of control valves to selectively thermally couple the second heating fluid circuit to at least a portion of the second plurality of heat sources, the control system also configured to actuate a third set of control valves to selectively thermally couple the third heating fluid circuit to at least a portion of the third plurality of heat sources, the control system also configured to actuate a fourth set of control valves to selectively thermally couple the fourth heating fluid circuit to at least a portion of the fourth plurality of heat sources, and the control system also configured to actuate a fifth set of control valves to selectively thermally couple the fifth heating fluid circuit to at least a portion of the fifth plurality of heat sources.