A cap comprising: a housing comprising: a top wall; an essentially cylindrical sidewall forming a first cavity; and an open bottom formed by the cylindrical sidewall with an opening to the first cavity within the housing for receiving a hub of a medical connector (450, 460); and a protrusion extending from the housing and positioned within the first cavity, the protrusion having an inner surface and an outer surface, the inner surface of the protrusion defining a second cavity, an inner thread on the inner surface of the protrusion, the inner thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a female medical connector, and an outer thread on the outer surface of the protrusion, the outer thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a male medical connector; a disinfection sponge configured within the second cavity, the disinfection sponge comprising a slotted end; an essentially cylindrical sponge sidewall defining a hollow and an open end; and a sponge end wall; and characterized by a pressure seal disposed in the hollow of the disinfection sponge, the pressure seal comprising: an elongate member extending from an interior surface of the top wall of the housing; and an insert comprising a bottom wall, and an essentially cylindrical insert sidewall, the insert sidewall forming a chamber and a top edge of the insert sidewall defining an aperture; the insert slidably engaging with the elongate member; wherein upon engagement of the cap with the medical connector (450, 460), the disinfection sponge contacts a lumen edge of the medical connector (450, 460) and the insert of the pressure seal blocks a lumen of the medical connector (450, 460) thereby inhibiting disinfectant ingress into the lumen. comprising: a top wall; an essentially cylindrical sidewall forming a first cavity; and an open bottom formed by the cylindrical sidewall with an opening to the first cavity within the housing for receiving a hub of a medical connector (450, 460); and a top wall; an essentially cylindrical sidewall forming a first cavity; and an open bottom formed by the cylindrical sidewall with an opening to the first cavity within the housing for receiving a hub of a medical connector (450, 460); and a protrusion extending from the housing and positioned within the first cavity, the protrusion having an inner surface and an outer surface, the inner surface of the protrusion defining a second cavity, an inner thread on the inner surface of the protrusion, the inner thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a female medical connector, and an outer thread on the outer surface of the protrusion, the outer thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a male medical connector; an inner thread on the inner surface of the protrusion, the inner thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a female medical connector, and an outer thread on the outer surface of the protrusion, the outer thread being sufficient to interlock with a mating feature of the medical connector (450, 460) comprising a male medical connector; a disinfection sponge configured within the second cavity, the disinfection sponge comprising a slotted end; an essentially cylindrical sponge sidewall defining a hollow and an open end; and a sponge end wall; and characterized by a pressure seal disposed in the hollow of the disinfection sponge, the pressure seal comprising: an elongate member extending from an interior surface of the top wall of the housing; and an insert comprising a bottom wall, and an essentially cylindrical insert sidewall, the insert sidewall forming a chamber and a top edge of the insert sidewall defining an aperture; the insert slidably engaging with the elongate member; wherein upon engagement of the cap with the medical connector (450, 460), the disinfection sponge contacts a lumen edge of the medical connector (450, 460) and the insert of the pressure seal blocks a lumen of the medical connector (450, 460) thereby inhibiting disinfectant ingress into the lumen. an elongate member extending from an interior surface of the top wall of the housing; and an insert comprising a bottom wall, and an essentially cylindrical insert sidewall, the insert sidewall forming a chamber and a top edge of the insert sidewall defining an aperture; the insert slidably engaging with the elongate member; wherein upon engagement of the cap with the medical connector (450, 460), the disinfection sponge contacts a lumen edge of the medical connector (450, 460) and the insert of the pressure seal blocks a lumen of the medical connector (450, 460) thereby inhibiting disinfectant ingress into the lumen.