mhurhangee/ep-ind-claims huggingface dataset:
An AAV8 or AAV9 vector comprising a nucleic acid that encodes a RPGR-ORF15 protein having the amino acid sequence of SEQ ID NO: 4, 23 or 25, wherein the nucleic acid comprises an intact purine stretch of the RPGR-ORF15 gene and: (a) a 5' AAV2 inverted terminal repeat and a 3' AAV2 ITR; (b) a human β-globin polyadenylation signal; (c) a CMV/human β-globin intron; and (d) the said nucleic acid that encodes RPGR-ORF15 under the control of the human rhodopsin kinase promoter. (a) a 5' AAV2 inverted terminal repeat and a 3' AAV2 ITR; (b) a human β-globin polyadenylation signal; (c) a CMV/human β-globin intron; and (d) the said nucleic acid that encodes RPGR-ORF15 under the control of the human rhodopsin kinase promoter.
A gas water heating appliance comprising: a housing; a burner disposed in the housing to generate heat; a heat exchanger for absorbing the heat and transferring the heat to water passing therethrough; an air supply fan disposed in the housing for supplying air to the burner; characterized in that an air pressure switch having a negative pressure port and a positive pressure port, said negative pressure port being connected to the air supply fan via a first tube, and said positive pressure port being connected to atmosphere via a second tube; and in that the housing defines an air inlet at a lower portion thereof; wherein the second tube has an air intake end, and said air intake end is located adjacent to the air inlet to receive air passing through the air inlet; said air inlet is defined in a front plate of the housing, and said front plate is provided with a shield plate having a bottom edge which forms a top edge of the air inlet; wherein the air intake end is disposed behind the shield plate. a housing; a burner disposed in the housing to generate heat; a heat exchanger for absorbing the heat and transferring the heat to water passing therethrough; an air supply fan disposed in the housing for supplying air to the burner; characterized in that an air pressure switch having a negative pressure port and a positive pressure port, said negative pressure port being connected to the air supply fan via a first tube, and said positive pressure port being connected to atmosphere via a second tube; and in that the housing defines an air inlet at a lower portion thereof; wherein the second tube has an air intake end, and said air intake end is located adjacent to the air inlet to receive air passing through the air inlet; said air inlet is defined in a front plate of the housing, and said front plate is provided with a shield plate having a bottom edge which forms a top edge of the air inlet; wherein the air intake end is disposed behind the shield plate.
A polymeric matrix comprising a crosslinked network of end-of-life tire- derived rubber and at least one complementary polymer, wherein the polymeric matrix encapsulates carbon black and/or graphene particles.
A vehicle comprising a display and a processor, the processor being configured to calculate the maximum wading depth of the vehicle in dependence on one or more vehicle parameters, wherein the processor is configured to display the maximum wading depth on the display wherein the display comprises an elevation of a vehicle on which is superimposed a line indicative of maximum wading depth, the vehicle further including a wading depth indicator, said display simultaneously displaying the maximum wading depth and current water level on said elevation.
A double elastic foam assembly for a saddle including a first foam material layer and a high-elasticity foam material layer formed on the first foam material layer, the saddle being adapted to receive a cyclist to sit thereon so that two portions of the saddle that correspond to portions of the cyclist associated with the ischiums of the cyclist are defined as ischiatic pressure bearing zones, characterized in that the double elastic foam assembly comprises: the first foam material layer formed with a pair of first hollowed zones at locations corresponding to the ischiatic pressure bearing zones of the saddle, each of the first hollowed zones receiving therein a second foam material layer; and the high-elasticity foam material layer formed with a pair of second hollowed zones at locations corresponding to the ischiums of the cyclist, each of the second hollowed zones receiving therein a memory foam layer that is in alignment, in a vertical direction, with the second foam material layer of the first hollowed zone; wherein the ischiatic pressure bearing zones of the saddle receive and bear vibration forces applied by the ischiums of the cyclist thereto in the vertical direction, and the memory foam layers and the second foam material layers collaboratively absorb the vibration forces. the first foam material layer formed with a pair of first hollowed zones at locations corresponding to the ischiatic pressure bearing zones of the saddle, each of the first hollowed zones receiving therein a second foam material layer; and the high-elasticity foam material layer formed with a pair of second hollowed zones at locations corresponding to the ischiums of the cyclist, each of the second hollowed zones receiving therein a memory foam layer that is in alignment, in a vertical direction, with the second foam material layer of the first hollowed zone; wherein the ischiatic pressure bearing zones of the saddle receive and bear vibration forces applied by the ischiums of the cyclist thereto in the vertical direction, and the memory foam layers and the second foam material layers collaboratively absorb the vibration forces.
A combination of levocetirizine and montelukast in an effective amount for use in the treatment of a traumatic injury or a symptom of traumatic injury in a patient in need thereof.
Procedure designed to measure the flow and the flow direction of a medium in a measuring tube, with a thermal flowmeter designed to determine and/or monitor the flow of a medium through a measuring tube with a control/evaluation unit, a first sensor and at least a second sensor, which are at least partially arranged in the measuring tube, wherein the first sensor has a first heatable resistance thermometer, and wherein the second sensor has a second heatable resistance thermometer, and wherein the thermal flowmeter has a body which guides the flow and which is arranged in the measuring tube with the second heatable resistance thermometer in a line that is essentially parallel to the measuring tube axis, wherein the first heatable resistance thermometer is arranged at a distance from the second resistance thermometer in the measuring tube, characterized in that the control/evaluation unit and the second sensor are designed in such a way that, at a certain point in time, the second resistance thermometer absorbs a defined heating capacity and/or in that a defined voltage drops at the second resistance thermometer at a certain point in time, wherein the measured values T medium,actual (t) representing the temperature of the medium are measured at the times t=t 0, t 1, t 2, t 3,... t n, wherein a first heating capacity P 1.1 (t 1) is absorbed by the first heatable resistance thermometer at time t 1, wherein a second heating capacity P 2.2 (t 2) is absorbed by the second heatable resistance thermometer at time t 2, wherein the first heatable resistance thermometer makes available a first measured value for the temperature T 1,heated,actual (t 1) at the time t 1 and in that a first coefficient PC 1 (t 1) representing the flow of medium through the measuring tube is calculated as a function of the heating capacity P 1.1 (t 1) absorbed by the first resistance thermometer, the temperature of the medium T medium, actual (t 1) and the temperature of the first heatable resistance thermometer T 1,heated, actual (t 1), wherein the second heatable resistance thermometer makes available a second measured value for the temperature T 2,heated,actual (t 2) at the time t 2, and in that a second coefficient PC 2 (t 2) is calculated as a function of the heating capacity P 2.2 (t 2) absorbed by the second resistance thermometer, the temperature of the medium T medium,actual (t 2) and the temperature of the second heatable resistance thermometer T 2,heated,actual (t 2), and wherein a decision coefficient is calculated as a function of the first coefficient PC 1 (t 1) and of the second coefficient PC 2 (t 2), wherein the value of the decision coefficient indicates a flow of the medium in the measuring tube in a first flow direction if the value of the decision coefficient is above a predefined limit value and wherein the value of the decision coefficient indicates a flow of the medium in the measuring tube in a second flow direction if the value of the decision coefficient is below the predefined limit value, wherein the second flow direction points in the direction opposite to the first flow direction.
Coated substrate comprising a substrate material, which is coated at least in part with an oxidation-resistant coating, wherein the coating consists of or comprises a wear-resistant abrasive coating layer, which consists of coated abrasive particles embedded in an oxidation-resistant matrix material, wherein at least some of the abrasive particles consist of α-Al 2 O 3, wherein the abrasive particles are coated with a first particles coating layer disposed on the abrasive particles and a second particle coating layer disposed on the first particles coating layer, wherein the matrix material consists of or comprises the compound MCrAlY, and wherein M is at least one element selected from the group consisting of Ni, Co and Fe, and wherein the first particles coating layer is chemically bonded to the substrate material.
A method for manufacturing an electrolytic copper foil for a lithium secondary battery by using an apparatus for electrolytic deposition, the apparatus comprising a rotating drum and a positive electrode plate, in an electrolytic bath, wherein copper sulphate solution is used as an electrolytic solution for electroplating and a thiourea-based compound containing thiourea, chlorine and total organic carbon is used as an additive put into the copper sulphate solution, wherein concentration of each component contained in the thiourea-based compound is controlled so that thiourea has a concentration of 0.1 to 3 ppm, chlorine has a concentration of less than 5 ppm, and TOC has a concentration of less than 50 ppm in the electrolytic bath, and wherein the electrolytic copper foil is electroplated on the rotating drum with a current density of 10 ASD to 80 ASD, characterized in that the weight deviation of the electrolytic copper foil is controlled by installing a shielding plate or auxiliary positive electrode at a region deviating from core, wherein the weight deviation is a value obtained by (i) cutting a sample of 10cm×10cm out of each of left, right and center portions of the electrolytic copper foil, (ii) measuring weights of the respective samples, and (iii) calculating the weight deviation according to a following formula: * weight deviation % = maximum weight − minimum weight / average weight × 100 wherein the maximum weight is a maximum value among the measured weights of the samples, the minimum weight is a minimum value among the measured weights of the samples, and the average weight is an average value of the measured weights of the samples. characterized in that the weight deviation of the electrolytic copper foil is controlled by installing a shielding plate or auxiliary positive electrode at a region deviating from core, wherein the weight deviation is a value obtained by (i) cutting a sample of 10cm×10cm out of each of left, right and center portions of the electrolytic copper foil, (ii) measuring weights of the respective samples, and (iii) calculating the weight deviation according to a following formula: * weight deviation % = maximum weight − minimum weight / average weight × 100 wherein the maximum weight is a maximum value among the measured weights of the samples, the minimum weight is a minimum value among the measured weights of the samples, and the average weight is an average value of the measured weights of the samples.
Flame retardant bar element (10; 12; 14, 16) consisting of polyurethane foam (PUR-foam) and/or polyisocyanurate foam (PIR-foam), for heat insulation systems (WDVS) at buildings (38; 40; 42), characterised by a homogenous apparent density, for the determination of which a pore volume in the material volume is taken into account, wherein - in a distribution of measurements of apparent density, which is determined via sample volumes embodied as cubes having a 10 mm edge length and obtained from a portion of the flame retardant bar element from a middle plane located parallel to an exterior surface through a volume center up to the exterior surface - at least 70%of the obtained measurement values of the apparent density are in an interval of ± 20% round a statistic average value, wherein at least one fixation surface (18, 20, 22) is embodied by an open-pored surface, in particular a cut surface, at which coatings of a material for the purpose of a color design and/or of fixation adhere without intermediary carrier.
A dual vector system comprising: (a) a gene editing AAV vector comprising a Cas9 gene under control of regulatory sequences which direct expression of the Cas9 in a target cell comprising a targeted gene which has one or more mutations resulting in a disorder; (b) a targeting AAV vector comprising one or more sgRNA and a donor template, wherein the one or more sgRNA individually comprise at least 20 nucleotides which specifically bind to a selected site in the targeted genes and which selected site is 5' to a protospacer-adjacent motif which is specifically recognized by the Cas9, and wherein the donor template comprises nucleic acid sequences which replaces at least one of the mutations in the targeted gene; wherein the ratio of the gene editing AAV vector (a) to the targeting AAV vector (b) is such that the targeting AAV vector (b) is in excess of the gene editing AAV vector (a), as determined based on vector genome copies of (a) and (b), and wherein the target cells are hepatocytes or liver cells. (a) a gene editing AAV vector comprising a Cas9 gene under control of regulatory sequences which direct expression of the Cas9 in a target cell comprising a targeted gene which has one or more mutations resulting in a disorder; (b) a targeting AAV vector comprising one or more sgRNA and a donor template, wherein the one or more sgRNA individually comprise at least 20 nucleotides which specifically bind to a selected site in the targeted genes and which selected site is 5' to a protospacer-adjacent motif which is specifically recognized by the Cas9, and wherein the donor template comprises nucleic acid sequences which replaces at least one of the mutations in the targeted gene;
Use of a thermoplastic resin composition, comprising: a-1) 1 to 30 % by weight of a first graft polymer obtained by graft-polymerizing an aromatic vinyl compound and a vinyl cyanide compound onto a conjugated diene rubber having an average particle diameter of 0.05 μm or more and less than 0.2 μm; a-2) 5 to 45 % by weight of a second graft polymer obtained by graft-polymerizing an aromatic vinyl compound and a vinyl cyanide compound onto a conjugated diene rubber having an average particle diameter of 0.2 to 0.5 μm; b) 50 to 80 % by weight of an aromatic vinyl compound-vinyl cyanide compound copolymer; and c) 1 to 10 % by weight of a (meth)acrylic acid alkyl ester polymer as a plating material in a plating process comprising using a chromium-free etchant to plate the thermoplastic resin composition. a-1) 1 to 30 % by weight of a first graft polymer obtained by graft-polymerizing an aromatic vinyl compound and a vinyl cyanide compound onto a conjugated diene rubber having an average particle diameter of 0.05 μm or more and less than 0.2 μm; a-2) 5 to 45 % by weight of a second graft polymer obtained by graft-polymerizing an aromatic vinyl compound and a vinyl cyanide compound onto a conjugated diene rubber having an average particle diameter of 0.2 to 0.5 μm; b) 50 to 80 % by weight of an aromatic vinyl compound-vinyl cyanide compound copolymer; and c) 1 to 10 % by weight of a (meth)acrylic acid alkyl ester polymer as a plating material in a plating process comprising using a chromium-free etchant to plate the thermoplastic resin composition.
An apparatus for determining the contact force between two components (13, 14), of which at least one is movable, comprising: a deformation body which can be attached to one of the components such that it is at least regionally strained under the influence of the contact force; a first strain sensor attached to the deformation body for detecting the strain; and an evaluation device which is configured to determine a static contact force with reference to the detected strain, characterized in that a test mass is provided at a flexible section of the deformation body such that it can carry out oscillating movements in and against the direction of the contact force, in which a second strain sensor is attached to the flexible section for detecting the bend; in which the evaluation device is configured to determine an acceleration of the test mass with reference to the detected bend and to determine a contact force compensated with respect to inertia on the basis of the determined static contact force and on the basis of the determined acceleration of the test mass; and in which the first strain sensor and/or the second strain sensor is/are configured as fiber optic sensors. a deformation body which can be attached to one of the components such that it is at least regionally strained under the influence of the contact force; a first strain sensor attached to the deformation body for detecting the strain; and an evaluation device which is configured to determine a static contact force with reference to the detected strain, characterized in that a test mass is provided at a flexible section of the deformation body such that it can carry out oscillating movements in and against the direction of the contact force, in which a second strain sensor is attached to the flexible section for detecting the bend; in which the evaluation device is configured to determine an acceleration of the test mass with reference to the detected bend and to determine a contact force compensated with respect to inertia on the basis of the determined static contact force and on the basis of the determined acceleration of the test mass; and in which the first strain sensor and/or the second strain sensor is/are configured as fiber optic sensors.
Electromagnetic switching device with an electromagnet and a movable magnet armature, and with at least one first resetting spring acting on the magnet armature which, in an OPEN position, exercises a holding force (F 1p,0) which is not zero on the magnet armature and which is supported on the magnet armature such that the direction of the overall force (F 1ges) exerted by it on the magnet armature depends on the position of the magnet armature such that the component (F 1p) of the overall force (F 1ges) acting against the direction of movement of the closing movement of the magnet armature is at its maximum in the OPEN position, characterised by at least a second resetting spring, of which the spring axis is oriented in parallel to the direction of movement of the magnet armature and which exerts a force on the magnet armature acting against the direction of movement of the closing movement of the magnet armature in the OPEN position.
A method for manufacturing a printed circuit board, the method comprising in this order the steps: (i) providing a non-conductive substrate having on at least one surface - a copper circuitry with a copper surface, wherein the copper surface is - chemically treated by (a) an oxidation and subsequent reduction reaction and/or (b) an organic compound attached to the copper surface, - a permanent, non-conductive, not fully polymerized cover layer covering at least partially said copper surface, (ii) thermally treating the substrate with the permanent, non-conductive, not fully polymerized cover layer at a temperature in the range from 140°C to 250°C in an atmosphere, which contains molecular oxygen in an amount of 100000 ppm or less, based on the total volume of the atmosphere, such that a substrate with a permanent, non-conductive cover layer is obtained, the cover layer being more polymerized compared to step (i), with the proviso: - that step (ii) is carried out after step (i) but before any metal or metal alloy is deposited onto the permanent, non-conductive, not fully polymerized cover layer, and - that in step (ii) the permanent, non-conductive, not fully polymerized cover layer is fully polymerized in solely one single thermal treating step, if the cover layer is a solder mask. (i) providing a non-conductive substrate having on at least one surface - a copper circuitry with a copper surface, wherein the copper surface is - chemically treated by (a) an oxidation and subsequent reduction reaction and/or (b) an organic compound attached to the copper surface, - a permanent, non-conductive, not fully polymerized cover layer covering at least partially said copper surface, - a copper circuitry with a copper surface, wherein the copper surface is - chemically treated by (a) an oxidation and subsequent reduction reaction and/or (b) an organic compound attached to the copper surface, - chemically treated by (a) an oxidation and subsequent reduction reaction and/or (b) an organic compound attached to the copper surface, - a permanent, non-conductive, not fully polymerized cover layer covering at least partially said copper surface, (ii) thermally treating the substrate with the permanent, non-conductive, not fully polymerized cover layer at a temperature in the range from 140°C to 250°C in an atmosphere, which contains molecular oxygen in an amount of 100000 ppm or less, based on the total volume of the atmosphere, such that a substrate with a permanent, non-conductive cover layer is obtained, the cover layer being more polymerized compared to step (i), - that step (ii) is carried out after step (i) but before any metal or metal alloy is deposited onto the permanent, non-conductive, not fully polymerized cover layer, and - that in step (ii) the permanent, non-conductive, not fully polymerized cover layer is fully polymerized in solely one single thermal treating step, if the cover layer is a solder mask.
A locking linear actuator, comprising: an actuator housing defining an internal longitudinal bore; an actuator piston disposed in the internal longitudinal bore, the actuator piston being configured to slidably move between a proximal retracted position and a distal extended position; and a lock sleeve disposed in the internal longitudinal bore, the lock sleeve being configured to slidably move between a distal locking position and a proximal unlocked position; and an actuator piston biasing mechanism configured to urge the actuator piston in a proximal direction in the internal longitudinal bore, toward the retracted position; wherein when the actuator piston is in the retracted position and the lock sleeve is in the locking position, a distal portion of the lock sleeve extends into a proximal portion of the actuator piston to prevent the actuator piston from leaving the retracted position. an actuator housing defining an internal longitudinal bore; an actuator piston disposed in the internal longitudinal bore, the actuator piston being configured to slidably move between a proximal retracted position and a distal extended position; and a lock sleeve disposed in the internal longitudinal bore, the lock sleeve being configured to slidably move between a distal locking position and a proximal unlocked position; and an actuator piston biasing mechanism configured to urge the actuator piston in a proximal direction in the internal longitudinal bore, toward the retracted position; wherein when the actuator piston is in the retracted position and the lock sleeve is in the locking position, a distal portion of the lock sleeve extends into a proximal portion of the actuator piston to prevent the actuator piston from leaving the retracted position.