Loading machine for cartridges with a metal case comprising: - a frame structure; - feed means for a plurality of cases having a given caliber and a longitudinally extending axis; - feed means for a plurality of ogival balls adapted to act as bullets; - feed means for gunpowder; - a first operating beam having an alternating vertical translation movement, provided with working tools having a vertical axis, adapted to load said cases; - a second operating beam, having an alternating vertical translation movement coordinated with the alternating vertical translation movement of said first operating beam, wherein said second operating beam is provided with a plurality of hollow centering cylinders, having a vertical axis, each centering cylinder being arranged so that its vertical axis coincides with the vertical axis of one of said tools, - feed and conveying means of said cases during loading; - means for ejecting the loaded cartridges; - motor means adapted to produce a continuous rotational motion for activation of kinematic mechanisms; - a control unit, where said frame structure comprises vertical guides engaged simultaneously by said first and said second operating beam, characterized in that said loading machine comprises a gearbox for transmission of motion from said motor means to said first and said second operating beam, and said gearbox comprises: - a drive shaft having a longitudinal axis (x), operated by said motor means; - at least a first and a second connecting rod and crank kinematic mechanism connected to said first operating beam; - at least a third and a fourth connecting rod and crank kinematic mechanism connected to said second operating beam, where: - said first and said second kinematic mechanism are connected to said drive shaft respectively by means of a first cam and a second cam with globoidal profile; - said third and said fourth kinematic mechanism are connected to said drive shaft respectively by means of a third cam and a fourth cam with globoidal profile, so that the alternating vertical translation movement of said first beam is independent from the alternating movement of said second beam. - a frame structure; - feed means for a plurality of cases having a given caliber and a longitudinally extending axis; - feed means for a plurality of ogival balls adapted to act as bullets; - feed means for gunpowder; - a first operating beam having an alternating vertical translation movement, provided with working tools having a vertical axis, adapted to load said cases; - a second operating beam, having an alternating vertical translation movement coordinated with the alternating vertical translation movement of said first operating beam, wherein said second operating beam is provided with a plurality of hollow centering cylinders, having a vertical axis, each centering cylinder being arranged so that its vertical axis coincides with the vertical axis of one of said tools, - feed and conveying means of said cases during loading; - means for ejecting the loaded cartridges; - motor means adapted to produce a continuous rotational motion for activation of kinematic mechanisms; - a control unit, - a drive shaft having a longitudinal axis (x), operated by said motor means; - at least a first and a second connecting rod and crank kinematic mechanism connected to said first operating beam; - at least a third and a fourth connecting rod and crank kinematic mechanism connected to said second operating beam, - said first and said second kinematic mechanism are connected to said drive shaft respectively by means of a first cam and a second cam with globoidal profile; - said third and said fourth kinematic mechanism are connected to said drive shaft respectively by means of a third cam and a fourth cam with globoidal profile,