Compound according the following formula, or pharmaceutically acceptable salt, solvate, solvate of salt, tautomer or stereoisomer thereof, wherein: X 1 is N or CH, X 2 is CH 2 or NH, X 3 is CO, X 4 is O, CH 2 or NH, R 1 is Ar, Het, or unbranched or branched alkyl with 1-10 C-atoms, each of which is substituted by 1-6 of Hal, A, phenyl, CON(R 3) 2, COOR 3, NHCOA, NHSO 2 A, CHO, COA, SO 2 N(R 3) 2, SO 2 A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2 and/or [C(R 3) 2] p CN; R 2 is [C(R 3) 2] p Het 1 or A, R 3 is H or alkyl with 1, 2, 3, or 4 C-atoms, Ar is phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, phenyl, CON(R 3) 2, COOR 3, NHCOA, NHSO 2 A, CHO, COA, SO 2 N(R 3) 2, SO 2 A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2 and/or [C(R 3) 2] p CN, Het is furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl or quinolyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, CON(R 3) 2, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S m A and/or O[C(R 3) 2] q N(R 3) 2, Het 1 is dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydroimidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, azepanyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, tetrahydropyranyl, pyridyl or piperazinyl, which is unsubstituted or mono- or disubstituted by A, A is unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by F or Cl, Hal is F, Cl, Br or I, each m is independently 0, 1 or 2, each n is independently 1 or 2, each p is independently 0, 1, 2, 3 or 4, each q is independently 2, 3 or 4. X 1 is N or CH, X 2 is CH 2 or NH, X 3 is CO, X 4 is O, CH 2 or NH, R 1 is Ar, Het, or unbranched or branched alkyl with 1-10 C-atoms, each of which is substituted by 1-6 of Hal, A, phenyl, CON(R 3) 2, COOR 3, NHCOA, NHSO 2 A, CHO, COA, SO 2 N(R 3) 2, SO 2 A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2 and/or [C(R 3) 2] p CN; R 2 is [C(R 3) 2] p Het 1 or A, R 3 is H or alkyl with 1, 2, 3, or 4 C-atoms, Ar is phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, phenyl, CON(R 3) 2, COOR 3, NHCOA, NHSO 2 A, CHO, COA, SO 2 N(R 3) 2, SO 2 A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2 and/or [C(R 3) 2] p CN, Het is furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl or quinolyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, CON(R 3) 2, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S m A and/or O[C(R 3) 2] q N(R 3) 2, Het 1 is dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydroimidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, azepanyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, tetrahydropyranyl, pyridyl or piperazinyl, which is unsubstituted or mono- or disubstituted by A, A is unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by F or Cl, Hal is F, Cl, Br or I, each m is independently 0, 1 or 2, each n is independently 1 or 2, each p is independently 0, 1, 2, 3 or 4, each q is independently 2, 3 or 4.