An apparatus for manufacturing multi-piece closed-back isolation garments, the apparatus comprising: at least one die unit configured to cut a neck opening in the continuous shoulder web; a first bonding unit configured to bond the first shoulder web panel to the second shoulder web panel; the apparatus being characterized in further comprising: a slitting unit configured to cut and separate a continuous cover strip segment from a continuous shoulder web; a first folding unit configured to fold a second shoulder web panel of the continuous shoulder web over a first shoulder web panel of the continuous shoulder web and create an area on the first shoulder web panel that is uncovered by the second shoulder web panel; a first adhesive applicator configured to apply a first adhesive strip to the uncovered area of the first shoulder web panel; a perforation unit configured to cut a perforation line in a continuous torso web to define a first tie strap; a second folding unit configured to fold the continuous torso web into a tube; a cutting unit (528, 554) configured to cut a torso web piece from the folded continuous torso web; a transfer unit configured to transfer the torso web piece having a substantially tubular shape onto the first adhesive strip; a second adhesive applicator (590, 591) configured to apply a second adhesive strip to attach the continuous cover strip segment to the torso web piece and second shoulder web panel and forming a continuous isolation garment web; and at least one other adhesive applicator configured to attach a second tie strap to the torso web piece of the continuous isolation garment web. at least one die unit configured to cut a neck opening in the continuous shoulder web; a first bonding unit configured to bond the first shoulder web panel to the second shoulder web panel; the apparatus being characterized in further comprising: a slitting unit configured to cut and separate a continuous cover strip segment from a continuous shoulder web; a first folding unit configured to fold a second shoulder web panel of the continuous shoulder web over a first shoulder web panel of the continuous shoulder web and create an area on the first shoulder web panel that is uncovered by the second shoulder web panel; a first adhesive applicator configured to apply a first adhesive strip to the uncovered area of the first shoulder web panel; a perforation unit configured to cut a perforation line in a continuous torso web to define a first tie strap; a second folding unit configured to fold the continuous torso web into a tube; a cutting unit (528, 554) configured to cut a torso web piece from the folded continuous torso web; a transfer unit configured to transfer the torso web piece having a substantially tubular shape onto the first adhesive strip; a second adhesive applicator (590, 591) configured to apply a second adhesive strip to attach the continuous cover strip segment to the torso web piece and second shoulder web panel and forming a continuous isolation garment web; and at least one other adhesive applicator configured to attach a second tie strap to the torso web piece of the continuous isolation garment web. a slitting unit configured to cut and separate a continuous cover strip segment from a continuous shoulder web; a first folding unit configured to fold a second shoulder web panel of the continuous shoulder web over a first shoulder web panel of the continuous shoulder web and create an area on the first shoulder web panel that is uncovered by the second shoulder web panel; a first adhesive applicator configured to apply a first adhesive strip to the uncovered area of the first shoulder web panel; a perforation unit configured to cut a perforation line in a continuous torso web to define a first tie strap; a second folding unit configured to fold the continuous torso web into a tube; a cutting unit (528, 554) configured to cut a torso web piece from the folded continuous torso web; a transfer unit configured to transfer the torso web piece having a substantially tubular shape onto the first adhesive strip; a second adhesive applicator (590, 591) configured to apply a second adhesive strip to attach the continuous cover strip segment to the torso web piece and second shoulder web panel and forming a continuous isolation garment web; and at least one other adhesive applicator configured to attach a second tie strap to the torso web piece of the continuous isolation garment web.