A syringe assembly for use with a drug vial having a close ended drug vial tube, a tubular drug vial crown having a drug vial crown opening and a drug vial stopper for stopping the drug vial crown opening, the drug vial containing liquid drug contents, the syringe assembly having a longitudinal syringe assembly centerline and comprising: (a) a syringe including a proximal syringe end and a distal syringe tip, said syringe including an open ended syringe barrel having a proximal syringe barrel end and a distal syringe barrel end; (b) a liquid drug administration device for administrating the liquid drug contents; and (c) a puncturing cannula for puncturing the drug vial stopper, said puncturing cannula being in flow communication with said syringe barrel; characterised in that the liquid drug administration device is integral with the distal syringe tip, and the syringe assembly further comprises: (d) a drug vial adapter including a proximal tubular stem manually detachably mounted on said distal syringe tip, a distal downward depending skirt for telescopic mounting on the drug vial, and said puncturing cannula for puncturing the drug vial stopper on said telescopic mounting said drug vial adapter on the drug vial, and (e) a flow control member displaceable from an initial flow path position to a final flow path position, said flow control member arranged to provide a flow path between said puncturing cannula and said syringe barrel in said initial flow path position of said flow control member in an initial set-up position of the syringe assembly in which said drug vial adapter is initially detachably mounted on said distal syringe tip, the syringe assembly being such that, on manual detachment of said drug vial adapter from said distal syringe tip, including a manual rotation of said drug vial adapter relative to said syringe, the manual rotation of said drug vial adapter displaces said flow control member from said initial flow path position to said final flow path position, said flow control member arranged to provide a flow path between said syringe barrel and said liquid drug administration device in said final flow path position for enabling administering the liquid drug contents. (a) a syringe including a proximal syringe end and a distal syringe tip, said syringe including an open ended syringe barrel having a proximal syringe barrel end and a distal syringe barrel end; (b) a liquid drug administration device for administrating the liquid drug contents; and (c) a puncturing cannula for puncturing the drug vial stopper, said puncturing cannula being in flow communication with said syringe barrel; characterised in that the liquid drug administration device is integral with the distal syringe tip, and the syringe assembly further comprises: (d) a drug vial adapter including a proximal tubular stem manually detachably mounted on said distal syringe tip, a distal downward depending skirt for telescopic mounting on the drug vial, and said puncturing cannula for puncturing the drug vial stopper on said telescopic mounting said drug vial adapter on the drug vial, and (e) a flow control member displaceable from an initial flow path position to a final flow path position, said flow control member arranged to provide a flow path between said puncturing cannula and said syringe barrel in said initial flow path position of said flow control member in an initial set-up position of the syringe assembly in which said drug vial adapter is initially detachably mounted on said distal syringe tip, the syringe assembly being such that, on manual detachment of said drug vial adapter from said distal syringe tip, including a manual rotation of said drug vial adapter relative to said syringe, the manual rotation of said drug vial adapter displaces said flow control member from said initial flow path position to said final flow path position, said flow control member arranged to provide a flow path between said syringe barrel and said liquid drug administration device in said final flow path position for enabling administering the liquid drug contents. (d) a drug vial adapter including a proximal tubular stem manually detachably mounted on said distal syringe tip, a distal downward depending skirt for telescopic mounting on the drug vial, and said puncturing cannula for puncturing the drug vial stopper on said telescopic mounting said drug vial adapter on the drug vial, and (e) a flow control member displaceable from an initial flow path position to a final flow path position, said flow control member arranged to provide a flow path between said puncturing cannula and said syringe barrel in said initial flow path position of said flow control member in an initial set-up position of the syringe assembly in which said drug vial adapter is initially detachably mounted on said distal syringe tip, the syringe assembly being such that, on manual detachment of said drug vial adapter from said distal syringe tip, including a manual rotation of said drug vial adapter relative to said syringe, the manual rotation of said drug vial adapter displaces said flow control member from said initial flow path position to said final flow path position, said flow control member arranged to provide a flow path between said syringe barrel and said liquid drug administration device in said final flow path position for enabling administering the liquid drug contents.