mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for site-specific insertion of foreign DNA into a genome in an animal cell, comprising: a step of constructing a donor plasmid in which DNA of 125 bp to 200 bp having a sequence homologous to an insertion site on a genome is ligated to the upstream and downstream of foreign DNA of 0.1 kbp to 10 kbp; and a step of inserting the foreign DNA of 0.1 kbp to 10 kbp into a target site on the genome by homology-directed repair-based genome editing using the obtained donor plasmid, wherein the animal cell is a human HCT116 cell, or a mouse ES cell, wherein the homology-directed repair-based genome editing method is a foreign DNA insertion method using a CRISPR-Cas9 system, and wherein the DNA having a sequence homologous to the inserted genomic site is obtained by PCR or DNA synthesis. a step of constructing a donor plasmid in which DNA of 125 bp to 200 bp having a sequence homologous to an insertion site on a genome is ligated to the upstream and downstream of foreign DNA of 0.1 kbp to 10 kbp; and a step of inserting the foreign DNA of 0.1 kbp to 10 kbp into a target site on the genome by homology-directed repair-based genome editing using the obtained donor plasmid, wherein the animal cell is a human HCT116 cell, or a mouse ES cell, wherein the homology-directed repair-based genome editing method is a foreign DNA insertion method using a CRISPR-Cas9 system, and wherein the DNA having a sequence homologous to the inserted genomic site is obtained by PCR or DNA synthesis. wherein the homology-directed repair-based genome editing method is a foreign DNA insertion method using a CRISPR-Cas9 system, and wherein the DNA having a sequence homologous to the inserted genomic site is obtained by PCR or DNA synthesis.
A composition for transdermal delivery, comprising: a drug reservoir comprising micronized particles of an amine salt form of an active agent dispersed in the drug reservoir, a proton accepting entity, and a salt form solubilizer; wherein the active agent is donepezil; wherein the proton accepting entity is sodium bicarbonate; and wherein the salt form solubilizer is selected from the group consisting of water, alcohols, glycerol, propylene glycol, ethylene glycol, dimethyl sulfoxide, and N-methylpyrrolidone. a drug reservoir comprising micronized particles of an amine salt form of an active agent dispersed in the drug reservoir, a proton accepting entity, and a salt form solubilizer; wherein the active agent is donepezil; wherein the proton accepting entity is sodium bicarbonate; and wherein the salt form solubilizer is selected from the group consisting of water, alcohols, glycerol, propylene glycol, ethylene glycol, dimethyl sulfoxide, and N-methylpyrrolidone.
A compound of the general formula: wherein each of R 1 -R 8 is independently selected from the group consisting of H, OH, SH, halogen, nitro, amino, nitrilo, nitroso, acetyl, acetamido, acylamido, alkylamino, straight or branched C 1 -C 5 alkyl, straight or branched C 1 -C 5 alkenyl, straight or branched C 1 -C 5 alkynyl, amine, straight or branched C 1 -C 5 alkoxy, straight or branched C 1 -C 5 carboxyl, straight or branched C 1 -C 5 ester, straight or branched C 1 -C 5 thioxy, straight or branched C 1 -C 5 sulfinyl and straight or branched C 1 -C 5 thionyl; R 9 is a straight or branched C 1 -C 9 alkyl, substituted with a group of the general formula: wherein each of R', R" and R"' is independently selected from a group consisting of straight or branched C 1 -C 9 alkyl, straight or branched C 1 -C 9 alkenyl and straight or branched C 1 -C 9 alkynyl; and wherein at least one of R 1 -R 4 is a halogen; or at least one of R 5 -R 8 is a halogen; or at least one of R 1 -R 4 is a halogen and at least one of R 5 -R 8 is a halogen; or at least one of R 1 -R 4 is OH; or at least one of R 5 -R 8 is OH; or at least one of R 1 -R 4 is a nitro; or at least one of R 1 -R 4 is a nitro and at least one of R 5 -R 8 is a nitro. each of R 1 -R 8 is independently selected from the group consisting of H, OH, SH, halogen, nitro, amino, nitrilo, nitroso, acetyl, acetamido, acylamido, alkylamino, straight or branched C 1 -C 5 alkyl, straight or branched C 1 -C 5 alkenyl, straight or branched C 1 -C 5 alkynyl, amine, straight or branched C 1 -C 5 alkoxy, straight or branched C 1 -C 5 carboxyl, straight or branched C 1 -C 5 ester, straight or branched C 1 -C 5 thioxy, straight or branched C 1 -C 5 sulfinyl and straight or branched C 1 -C 5 thionyl; R 9 is a straight or branched C 1 -C 9 alkyl, substituted with a group of the general formula: wherein each of R', R" and R"' is independently selected from a group consisting of straight or branched C 1 -C 9 alkyl, straight or branched C 1 -C 9 alkenyl and straight or branched C 1 -C 9 alkynyl; and wherein at least one of R 1 -R 4 is a halogen; or at least one of R 5 -R 8 is a halogen; or at least one of R 1 -R 4 is a halogen and at least one of R 5 -R 8 is a halogen; or at least one of R 1 -R 4 is OH; or at least one of R 5 -R 8 is OH; or at least one of R 1 -R 4 is a nitro; or at least one of R 1 -R 4 is a nitro and at least one of R 5 -R 8 is a nitro.
A base station comprising: a transceiver configured to enable communication with a user equipment, UE, in a wireless network; and one or more processors communicatively coupled to the transceiver and configured to: receive an uplink, UL, transmission from the UE carrying a tracking reference signal, TRS, request to trigger a TRS transmission from the base station; and generate, based upon the TRS request, a downlink, DL, transmission, wherein the DL transmission carries the TRS transmission and a Synchronization Signal block, SS-block, transmission within a slot, wherein the TRS transmission is allocated to one or more subcarriers in a symbol within the slot and outside resource blocks used for the SS-block transmission in the same symbol in which the TRS transmission is allocated to, and wherein the one or more subcarriers for the TRS transmission are adjacent to one or more subcarriers for the SS-block transmission. a transceiver configured to enable communication with a user equipment, UE, in a wireless network; and one or more processors communicatively coupled to the transceiver and configured to: receive an uplink, UL, transmission from the UE carrying a tracking reference signal, TRS, request to trigger a TRS transmission from the base station; and generate, based upon the TRS request, a downlink, DL, transmission, wherein the DL transmission carries the TRS transmission and a Synchronization Signal block, SS-block, transmission within a slot, wherein the TRS transmission is allocated to one or more subcarriers in a symbol within the slot and outside resource blocks used for the SS-block transmission in the same symbol in which the TRS transmission is allocated to, and wherein the one or more subcarriers for the TRS transmission are adjacent to one or more subcarriers for the SS-block transmission. receive an uplink, UL, transmission from the UE carrying a tracking reference signal, TRS, request to trigger a TRS transmission from the base station; and generate, based upon the TRS request, a downlink, DL, transmission, wherein the DL transmission carries the TRS transmission and a Synchronization Signal block, SS-block, transmission within a slot, wherein the TRS transmission is allocated to one or more subcarriers in a symbol within the slot and outside resource blocks used for the SS-block transmission in the same symbol in which the TRS transmission is allocated to, and wherein the one or more subcarriers for the TRS transmission are adjacent to one or more subcarriers for the SS-block transmission.
A combination comprising: a wave energy converter having a shaft and a shell intended to be placed in a body of water, the shaft and shell being able to move relative to each other in response to forces applied to the WEC by waves in the body of water; power take off means connected between the shaft and the shell for: extracting energy from the WEC and for producing output electric energy as a function of the relative movement between the shell and the shaft; and means for sensing and determining selected ones of the displacement, velocity and acceleration of one of the shell and the shaft and, in response to signals indicative that one of the shell and the shaft is at, or near, its maximum displacement and the velocity of said one of the shell and the shaft is going towards zero or just passes zero, electrical energy is selectively and actively supplied to one of the shell and shaft for causing an increase in the displacement and velocity of one of the shell and shaft relative to the other thereby changing the phase relationship between the forces of the waves and the motion of the WEC for increasing the net amount of output electrical energy produced by said PTO means. a wave energy converter having a shaft and a shell intended to be placed in a body of water, the shaft and shell being able to move relative to each other in response to forces applied to the WEC by waves in the body of water; power take off means connected between the shaft and the shell for: extracting energy from the WEC and for producing output electric energy as a function of the relative movement between the shell and the shaft; and means for sensing and determining selected ones of the displacement, velocity and acceleration of one of the shell and the shaft and, in response to signals indicative that one of the shell and the shaft is at, or near, its maximum displacement and the velocity of said one of the shell and the shaft is going towards zero or just passes zero, electrical energy is selectively and actively supplied to one of the shell and shaft for causing an increase in the displacement and velocity of one of the shell and shaft relative to the other thereby changing the phase relationship between the forces of the waves and the motion of the WEC for increasing the net amount of output electrical energy produced by said PTO means.
A method of receiving information for streaming of media data using Moving Pictures Experts Group dynamic adaptive streaming over HTTP, MPEG DASH, the method comprising: receiving, by a client device (40, 134), a media presentation description, MPD, for media content, wherein the MPD includes data indicative of wall-clock times at which the client device can retrieve data of the media content from a source device, and wherein the data indicates a synchronization method by which the client device is to synchronize the wall-clock times with a clock of the client device, and wherein the synchronization method indicated by the MPD comprises HTTP, wherein the MPD includes data indicative of network addresses for one or more HTTP servers, and wherein synchronizing the clock comprises requesting a time from at least one of the HTTP servers; synchronizing the clock of the client device with the wall-clock times using the method indicated by the MPD, and wherein synchronizing the clock comprises sending an HTTP GET request to at least one of the HTTP servers and receiving, in response to the HTTP GET request, a well-formatted time stamp value that is formatted according to one of network time protocol, NTP, and Extensible Markup Language, XML, and an international organization for standardization, ISO, time code; and requesting data of the media content from the source device using the synchronized clock; and wherein the MPD includes data that indicates that the client device is to retrieve a segment of the media content at a first time and that a separate client device is to retrieve the segment at a second time different from the first time, and wherein requesting data comprises requesting the segment at or after the first time. receiving, by a client device (40, 134), a media presentation description, MPD, for media content, wherein the MPD includes data indicative of wall-clock times at which the client device can retrieve data of the media content from a source device, and wherein the data indicates a synchronization method by which the client device is to synchronize the wall-clock times with a clock of the client device, and wherein the synchronization method indicated by the MPD comprises HTTP, wherein the MPD includes data indicative of network addresses for one or more HTTP servers, and wherein synchronizing the clock comprises requesting a time from at least one of the HTTP servers; synchronizing the clock of the client device with the wall-clock times using the method indicated by the MPD, and wherein synchronizing the clock comprises sending an HTTP GET request to at least one of the HTTP servers and receiving, in response to the HTTP GET request, a well-formatted time stamp value that is formatted according to one of network time protocol, NTP, and Extensible Markup Language, XML, and an international organization for standardization, ISO, time code; and requesting data of the media content from the source device using the synchronized clock; and
A press plate for a radiographic imaging apparatus, comprising: a press section that is disposed to face towards an imaging face of an imaging table when incorporated in a radiographic imaging apparatus and is resiliently deformable; a support section that is disposed separated from the press section on the opposite side to the imaging face and has a higher overall rigidity than the press section, wherein the press section and the support section are integrally formed through coupling sections (26C and 26D) at their end portions such that a slit is provided to each of the side faces of the press plate, extending from a portion at one end side of the press section and the support section to span across to a portion at the other side thereof, and a movable support point portion that is movable in the slit and supports the press section at the opposite side to the imaging face, wherein an adjustment mechanism (264, 268) is provided and adapted to move the movable support point portion between the press section and the support section so that the position of support from the support section to the press section is changed by such movement, such that a reaction force occurring at the press section is adjusted according to a position of the movable support point portion to support the press section. a press section that is disposed to face towards an imaging face of an imaging table when incorporated in a radiographic imaging apparatus and is resiliently deformable; a support section that is disposed separated from the press section on the opposite side to the imaging face and has a higher overall rigidity than the press section, wherein the press section and the support section are integrally formed through coupling sections (26C and 26D) at their end portions such that a slit is provided to each of the side faces of the press plate, extending from a portion at one end side of the press section and the support section to span across to a portion at the other side thereof, and a movable support point portion that is movable in the slit and supports the press section at the opposite side to the imaging face, wherein an adjustment mechanism (264, 268) is provided and adapted to move the movable support point portion between the press section and the support section so that the position of support from the support section to the press section is changed by such movement, such that a reaction force occurring at the press section is adjusted according to a position of the movable support point portion to support the press section.
A hand drip coffee tumbler comprising: a container keeping dripped coffee; a filter unit seated at the top of the container; a grinder unit (30, 300) disposed over the filter unit and separably coupled to the container to grind coffee beans; and a cap separably coupled to the container, wherein the cap has an internal space enough for keeping the grinder unit when the cap is coupled to the top of the container, characterized in that the cap may be used to keep hot water and pour the hot water into the container through the filter unit keeping ground coffee beans and wherein a discharge hole for discharging hot water is formed through the side of the cap. a container keeping dripped coffee; a filter unit seated at the top of the container; a grinder unit (30, 300) disposed over the filter unit and separably coupled to the container to grind coffee beans; and a cap separably coupled to the container, wherein the cap has an internal space enough for keeping the grinder unit when the cap is coupled to the top of the container, characterized in that the cap may be used to keep hot water and pour the hot water into the container through the filter unit keeping ground coffee beans and wherein a discharge hole for discharging hot water is formed through the side of the cap.
A base portion assembly for a needleless valve system, said base portion assembly comprising: a base portion with a body; a valve coupling feature disposed on said body, wherein said valve coupling feature is configured for coupling to a base coupling feature of a valve of a positive displacement valve and a base coupling feature of a negative displacement valve; and a valve having said base coupling feature and coupled to said valve coupling feature, said valve being a negative displacement valve; the base portion further comprising: an air channel configured for association with an air channel in a positive displacement valve, wherein said negative displacement valve does not include an air channel. a base portion with a body; a valve coupling feature disposed on said body, wherein said valve coupling feature is configured for coupling to a base coupling feature of a valve of a positive displacement valve and a base coupling feature of a negative displacement valve; and a valve having said base coupling feature and coupled to said valve coupling feature, said valve being a negative displacement valve; the base portion further comprising: an air channel configured for association with an air channel in a positive displacement valve, wherein said negative displacement valve does not include an air channel.
A variable capacity vane pump having a pump control ring which is moveable to alter the capacity of the pump, the pump being operable at at least two selected equilibrium pressures, comprising: a pump casing having a pump chamber therein, said pump chamber having an inlet port and an outlet port; a pump control ring pivotable within the pump chamber to alter the capacity of the pump; a vane pump rotor rotatably mounted within the pump control ring, said vane pump rotor having a plurality of slidably mounted vanes engaging an inside surface of said pump control ring, the vane pump rotor having an axis of rotation eccentric from a centre of said pump control ring, the vane pump rotor rotates to pressurize fluid as the fluid moves from the inlet port to the outlet port; a first control chamber between the pump casing and the pump control ring, the first control chamber operable to receive pressurized fluid to create a force on the pump control ring; a second control chamber between the pump casing and the pump control ring, the second control chamber selectively operable to receive pressurized fluid to create a force to pivot the pump control ring to reduce the volumetric capacity of the pump; and a return spring acting between the pump control ring and the casing to bias the pump control ring towards a position of maximum volumetric capacity; characterized in that the first control chamber is positioned such that the force created by the pressurized fluid received in the first control chamber pivots the pump control ring to reduce the volumetric capacity of the pump, the return spring acting against the pivoting force of the first and second control chambers (60, 64) to establish an equilibrium pressure. a pump casing having a pump chamber therein, said pump chamber having an inlet port and an outlet port; a pump control ring pivotable within the pump chamber to alter the capacity of the pump; a vane pump rotor rotatably mounted within the pump control ring, said vane pump rotor having a plurality of slidably mounted vanes engaging an inside surface of said pump control ring, the vane pump rotor having an axis of rotation eccentric from a centre of said pump control ring, the vane pump rotor rotates to pressurize fluid as the fluid moves from the inlet port to the outlet port; a first control chamber between the pump casing and the pump control ring, the first control chamber operable to receive pressurized fluid to create a force on the pump control ring; a second control chamber between the pump casing and the pump control ring, the second control chamber selectively operable to receive pressurized fluid to create a force to pivot the pump control ring to reduce the volumetric capacity of the pump; and a return spring acting between the pump control ring and the casing to bias the pump control ring towards a position of maximum volumetric capacity;
A method comprising: determining an interaction navigational location; causing display of a perspective image (300, 310, 320, 500, 510, 520) that depicts a view of a portion of map information from the interaction navigational location; causing display of a video region indicator (502, 512, 522) that indicates that video content, which is panoramic video content and the video content is captured by a plurality of camera modules of a video capture apparatus, is available at a video navigational location, the video content depicting a view of a portion of the map information from the video navigational location; determining that the interaction navigational location has changed such the interaction navigational location corresponds with the video navigational location; and causing rendering of the video content, such that a viewing angle of the perspective image corresponds with the viewing angle of the panoramic video content, based, at least in part, on the interaction navigational location corresponding with the video navigational location. determining an interaction navigational location; causing display of a perspective image (300, 310, 320, 500, 510, 520) that depicts a view of a portion of map information from the interaction navigational location; causing display of a video region indicator (502, 512, 522) that indicates that video content, which is panoramic video content and the video content is captured by a plurality of camera modules of a video capture apparatus, is available at a video navigational location, the video content depicting a view of a portion of the map information from the video navigational location; determining that the interaction navigational location has changed such the interaction navigational location corresponds with the video navigational location; and causing rendering of the video content, such that a viewing angle of the perspective image corresponds with the viewing angle of the panoramic video content, based, at least in part, on the interaction navigational location corresponding with the video navigational location.
A method of operating a device for hair styling, the method being characterized by comprising: in response to detecting a change in an open/close state of arms of the device, identifying a current styling operation; determining a variation in temperature of hair between the current styling operation and a previous styling operation; and determining, based on the variation in temperature of hair, a count that the device has operated on a same strand of hair, to thereby control the hair styling. in response to detecting a change in an open/close state of arms of the device, identifying a current styling operation; determining a variation in temperature of hair between the current styling operation and a previous styling operation; and determining, based on the variation in temperature of hair, a count that the device has operated on a same strand of hair, to thereby control the hair styling.