A device configured for monitoring central-to-peripheral arterial pressure decoupling in a subject comprising: a sensor (100, 200) for providing arterial pressure waveform data from the subject; a processing system for executing code; a software module comprising computer-executable code for applying a first multivariate statistical model to the arterial pressure waveform data to determine the subject's first arterial tone, the first multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects that were experiencing central-to-peripheral arterial pressure decoupling, the first multivariate statistical model providing a value for the subject's first arterial tone, wherein the software module further comprises computer-executable code for applying a second multivariate statistical model to the arterial pressure waveform data to determine the subject's normal arterial tone, the second multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects with normal hemodynamic conditions, the second multivariate statistical model providing a value for the subject's second arterial tone; and a calculation module comprising computer-executable code for comparing the subject's first arterial tone to the subject's second arterial tone; wherein the processing system determines central-to-peripheral arterial pressure decoupling when a difference between the subject's first arterial tone and the subject's second arterial tone greater than a threshold value indicates that the subject is experiencing central-to-peripheral arterial pressure decoupling. a sensor (100, 200) for providing arterial pressure waveform data from the subject; a processing system for executing code; a software module comprising computer-executable code for applying a first multivariate statistical model to the arterial pressure waveform data to determine the subject's first arterial tone, the first multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects that were experiencing central-to-peripheral arterial pressure decoupling, the first multivariate statistical model providing a value for the subject's first arterial tone, wherein the software module further comprises computer-executable code for applying a second multivariate statistical model to the arterial pressure waveform data to determine the subject's normal arterial tone, the second multivariate statistical model being prepared from a set of arterial pressure waveform data from a group of test subjects with normal hemodynamic conditions, the second multivariate statistical model providing a value for the subject's second arterial tone; and a calculation module comprising computer-executable code for comparing the subject's first arterial tone to the subject's second arterial tone; wherein the processing system determines central-to-peripheral arterial pressure decoupling when a difference between the subject's first arterial tone and the subject's second arterial tone greater than a threshold value indicates that the subject is experiencing central-to-peripheral arterial pressure decoupling.