mhurhangee/ep-ind-claims huggingface dataset:
A covalent conjugate of an alpha amino acid ester and an inhibitor of the activity of the target intracellular enzyme p38 MAP kinase for use in a method of treatment of the human or animal body by therapy, wherein: the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid; the nitrogen of the amino group of the amino acid ester is substituted but not directly linked to a carbonyl moiety, or is left unsubstituted; and the alpha amino acid ester is conjugated to the inhibitor at a position remote from the binding interface between the inhibitor and the p38 MAP kinase enzyme; wherein the position of conjugation is remote when the inhibition of TNFα production in human whole blood exhibited by the conjugate is at least as high as that of the unconjugated inhibitor. the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid; the nitrogen of the amino group of the amino acid ester is substituted but not directly linked to a carbonyl moiety, or is left unsubstituted; and the alpha amino acid ester is conjugated to the inhibitor at a position remote from the binding interface between the inhibitor and the p38 MAP kinase enzyme; wherein the position of conjugation is remote when the inhibition of TNFα production in human whole blood exhibited by the conjugate is at least as high as that of the unconjugated inhibitor.
An aqueous laundry liquid detergent comprising alkyl ether sulphate surfactant and alkyl ethoxylate surfactant, wherein either at least 10% wt. of the alkyl ether sulphate surfactant is C16 or C18 alkyl, or at least 10% wt. of the alkyl ethoxylate surfactant is C16 or C18 alkyl, from 0.01 to 3% wt. of the composition a preservative selected from benzoic acid and salts thereof, alkylesters of p-hydroxybenzoic acid and salts thereof and wherein the composition has a pH of from 5.0 to 7.0 and the composition comprises from 10 to 40% wt surfactant.
A single molecule detection apparatus, comprising: a) a waveguide comprising: a core layer; and a first cladding layer, wherein at least one nanowell is formed in at least the first cladding layer, and the core layer of the waveguide has a larger refractive index than the first cladding layer; b) at least one light detector formed on or in a substrate, wherein the at least one nanowell and the light detector are arranged at opposite sides of the waveguide; and c) a light source. a) a waveguide comprising: a core layer; and a first cladding layer, wherein at least one nanowell is formed in at least the first cladding layer, and the core layer of the waveguide has a larger refractive index than the first cladding layer; a core layer; and a first cladding layer, wherein at least one nanowell is formed in at least the first cladding layer, and the core layer of the waveguide has a larger refractive index than the first cladding layer; b) at least one light detector formed on or in a substrate, wherein the at least one nanowell and the light detector are arranged at opposite sides of the waveguide; and c) a light source.
An in vitro method of promoting generation of exosomes from adult stem cell, the method comprising the steps of: - culturing of adult stem cells in a medium comprising thrombin; and - isolation of exosomes. - culturing of adult stem cells in a medium comprising thrombin; and - isolation of exosomes.
An episomal plasmid comprising a gene of interest and an autonomously replicating sequence which is not operably linked to the GOI, which ARS comprises or consists of a nucleotide sequence identified as any of SEQ ID NO:5-11.
Method for determining the longitudinal axis of symmetry between a front centre and a rear centre of a vehicle with the help of a line laser with an associated receiving unit designed as an adjusting device that has a vertical reference line on one side and an opto-acoustic transmitting unit on an opposite transmitting side, characterised by the following subsequent steps: a. Positioning the line laser under a front or rear end of the vehicle until a perpendicular laser beam of the line laser passes through the front or the rear centre point of the vehicle, b. Positioning the adjusting device under said end of the vehicle until the perpendicular laser beam is on the vertical reference line of the receiving unit, c. Leaving the receiving unit in this central position according to step b, d. Change the position of the line laser under the other end of the vehicle until the perpendicular laser beam runs through the opposite centre point at the other end of the vehicle, for which purpose e. the line laser is shifted in the x and/or y direction and f. is rotated about its central vertical axis until a horizontal laser beam of the line laser hits the transmitter side of the receiver unit facing away from the reference line according to step b, whereby g. this emits an acoustic signal in the now aligned position. a. Positioning the line laser under a front or rear end of the vehicle until a perpendicular laser beam of the line laser passes through the front or the rear centre point of the vehicle, b. Positioning the adjusting device under said end of the vehicle until the perpendicular laser beam is on the vertical reference line of the receiving unit, c. Leaving the receiving unit in this central position according to step b, d. Change the position of the line laser under the other end of the vehicle until the perpendicular laser beam runs through the opposite centre point at the other end of the vehicle, for which purpose e. the line laser is shifted in the x and/or y direction and f. is rotated about its central vertical axis until a horizontal laser beam of the line laser hits the transmitter side of the receiver unit facing away from the reference line according to step b, whereby g. this emits an acoustic signal in the now aligned position.
Football board game comprising: - an element representing a football field comprising a rectangular grid subdivided into bands (2,3), each band (2:3) being in turn subdivided into boxes and comprising action boxes (4,5,6) having at least one symbol associated with a possibility of game action and/or neutral boxes not having any symbol associated with a possibility of game action, - a plurality of player pieces, each player piece having at least one playing parameter of the player to which it refers and at least one value associated with the at last one playing parameter, - a piece representing a football, - at least one device capable of providing from time to time a random value, possibly different, which is combined with a playing parameter of at least one player piece which is relevant for the game action in progress, so as to determine the outcome of at least one type of game action; preferably, the value provided by said at least one device is a numerical value, - a set of game rules, wherein each player piece refers to a goalkeeper or to a movement player and wherein the movement player is a defender, a midfielder and a striker. - an element representing a football field comprising a rectangular grid subdivided into bands (2,3), each band (2:3) being in turn subdivided into boxes and comprising action boxes (4,5,6) having at least one symbol associated with a possibility of game action and/or neutral boxes not having any symbol associated with a possibility of game action, - a plurality of player pieces, each player piece having at least one playing parameter of the player to which it refers and at least one value associated with the at last one playing parameter, - a piece representing a football, - at least one device capable of providing from time to time a random value, possibly different, which is combined with a playing parameter of at least one player piece which is relevant for the game action in progress, so as to determine the outcome of at least one type of game action; preferably, the value provided by said at least one device is a numerical value, - a set of game rules,
A method for securely communicating messages using multi-factor authentication, comprising: receiving an encrypted message from a sender destined for an intended recipient; determining whether the intended recipient can decrypt the encrypted message; providing a notification to the intended recipient of the encrypted message, the notification including a designated link operable to facilitate access to the encrypted message, the designated link including a unique identifier associated with the encrypted message; receiving a request to access the encrypted message; authenticating the request according to a multi-factor authentication procedure, the authentication procedure including verifying whether the request corresponds to the designated link provided to the intended recipient; and in response to the request passing the authentication procedure, communicating a decrypted message corresponding to the encrypted message to the intended recipient in response to the intended recipient being unable to decrypt the encrypted message, otherwise forwarding the encrypted message to the intended recipient in response to the intended recipient being able to decrypt the encrypted message. receiving an encrypted message from a sender destined for an intended recipient; determining whether the intended recipient can decrypt the encrypted message; providing a notification to the intended recipient of the encrypted message, the notification including a designated link operable to facilitate access to the encrypted message, the designated link including a unique identifier associated with the encrypted message; receiving a request to access the encrypted message; authenticating the request according to a multi-factor authentication procedure, the authentication procedure including verifying whether the request corresponds to the designated link provided to the intended recipient; and in response to the request passing the authentication procedure, communicating a decrypted message corresponding to the encrypted message to the intended recipient in response to the intended recipient being unable to decrypt the encrypted message, otherwise forwarding the encrypted message to the intended recipient in response to the intended recipient being able to decrypt the encrypted message.
An electric power feed apparatus comprising an electric power transmission section including an electric power transmission coil for performing electric power transmission through a magnetic field and an auxiliary resonance section including a plurality of resonators each including an auxiliary coil (L31, L32), wherein during the electric power transmission the electric power transmission section is configured to perform a main resonance operation by a main resonant frequency and each resonator is configured to perform an auxiliary resonance operation by an auxiliary resonant frequency, wherein the main resonant frequency and the auxiliary resonant frequencies are different from each other, wherein an internal diameter of each of the auxiliary coils (L31, L32) in the plurality of resonators is smaller than an internal diameter of the electric power transmission coil, wherein the internal diameters of the auxiliary coils (L31, L32) are different from one another, wherein a central point of the electric power transmission coil and a central point (CP31, CP32) of each of the auxiliary coils (L31, L32) are located along a substantially same axis, and wherein a difference value between internal diameters of the electric power transmission coil and an outermost auxiliary coil and each difference value between internal diameters of adjacent auxiliary coils (L31, L32) gradually increase from the electric power transmission coil side toward the central point.
A method comprising: receiving, by a station, STA, in a wireless local area network, a first Physical layer Protocol Data Unit, PPDU, including a physical layer, PHY, header and a Medium Access Control, MAC, frame; decoding, by the STA, the MAC frame; checking, by the STA, information included in the MAC frame based on a MAC header of the MAC frame, the MAC header including at least one of a first address field and a second address field; and transmitting, by the STA to an access point, AP, a second PPDU including a PHY header, characterized in that, each of the PHY headers of the first PPDU and the second PPDU includes a signal, SIG, field having a uplink/downlink, UL/DL, indication subfield and a STA identifier, ID, subfield, in reception of the first PPDU, the STA checks the UL/DL indication subfield corresponds to a DL value and checks the STA ID subfield includes information on the STA's association identifier, AID, as a receiver's AID, in transmission of the second PPDU, the STA sets the UL/DL indication subfield to a UL value, and sets the STA ID subfield to information on the STA's AID as a transmitter's AID, and in that the DL/UL indication subfield is located before the STA ID subfield. receiving, by a station, STA, in a wireless local area network, a first Physical layer Protocol Data Unit, PPDU, including a physical layer, PHY, header and a Medium Access Control, MAC, frame; decoding, by the STA, the MAC frame; checking, by the STA, information included in the MAC frame based on a MAC header of the MAC frame, the MAC header including at least one of a first address field and a second address field; and transmitting, by the STA to an access point, AP, a second PPDU including a PHY header, characterized in that, each of the PHY headers of the first PPDU and the second PPDU includes a signal, SIG, field having a uplink/downlink, UL/DL, indication subfield and a STA identifier, ID, subfield, in reception of the first PPDU, the STA checks the UL/DL indication subfield corresponds to a DL value and checks the STA ID subfield includes information on the STA's association identifier, AID, as a receiver's AID, in transmission of the second PPDU, the STA sets the UL/DL indication subfield to a UL value, and sets the STA ID subfield to information on the STA's AID as a transmitter's AID, and in that the DL/UL indication subfield is located before the STA ID subfield.
A method for controlling the position of a vehicle (1b, 1c) having steerable wheels on a track of a racing vehicle game wherein the method comprises the steps of: - taking a first measurement of a lateral position of the vehicle (1b, 1c) on the track; - comparing the first measured lateral position with a desired lateral position for the vehicle (1b, 1c) so as to produce an error signal; - generating within a primary feedback loop of a steering servo a first input signal for a steering servo of the vehicle (1b, 1c) so as to minimise the error signal, the primary feedback loop having a first responsivity (Ks); - measuring the angle between the direction of propagation of the vehicle (1b, 1c) and a longitudinal axis of the track; and - generating within a secondary feedback loop of the steering servo a second input signal for the steering servo so as to minimise the measured angle, the secondary feedback loop having a second responsivity, characterised in that the second responsivity is made equal to the reciprocal of a responsivity (Kss) of the steering servo, such that the steerable wheel points in the direction that the vehicle should be travelling. - taking a first measurement of a lateral position of the vehicle (1b, 1c) on the track; - comparing the first measured lateral position with a desired lateral position for the vehicle (1b, 1c) so as to produce an error signal; - generating within a primary feedback loop of a steering servo a first input signal for a steering servo of the vehicle (1b, 1c) so as to minimise the error signal, the primary feedback loop having a first responsivity (Ks); - measuring the angle between the direction of propagation of the vehicle (1b, 1c) and a longitudinal axis of the track; and - generating within a secondary feedback loop of the steering servo a second input signal for the steering servo so as to minimise the measured angle, the secondary feedback loop having a second responsivity, characterised in that the second responsivity is made equal to the reciprocal of a responsivity (Kss) of the steering servo, such that the steerable wheel points in the direction that the vehicle should be travelling.
Method for filling a gripper for bulk material, said gripper being suspended on holding cables, raised and lowered by a crane via a controller and acting on the bulk material with its own weight during the closing and filling procedure, wherein by reducing the effect of the weight of the gripper on the bulk material, a fill degree of the gripper is influenced via the controller in that a tensile force acting on the holding cables is influenced, characterised in that a tensile force TARGET value (Fsoll) is determined for the holding cables via the controller, the tensile force TARGET value (Fsoll) is output to a tensile force controller as an input variable, an electric motor for lifting and lowering the gripper is controlled by the tensile force controller and an ascertained tensile force ACTUAL value (Fist) of the holding cables is supplied to the tensile force controller as an input variable.
A reference signal notification method, comprising: sending, by a network device, a reference signal notification message, wherein the reference signal notification message comprises time resource information of a reference signal; wherein the reference signal is a CSI-RS, and the time resource information is at least one of subframe configuration information, a time offset, and measurement window information of the CSI-RS; wherein the reference signal notification message further comprises a cell identity and numerology information of the CSI-RS. sending, by a network device, a reference signal notification message, wherein the reference signal notification message comprises time resource information of a reference signal; wherein the reference signal is a CSI-RS, and the time resource information is at least one of subframe configuration information, a time offset, and measurement window information of the CSI-RS; wherein the reference signal notification message further comprises a cell identity and numerology information of the CSI-RS.
A composition comprising: - from 4% to 6% by weight of difluoromethane; - from 2.5% to 3.5% by weight of pentafluoroethane; and - from 91% to 93.5% by weight of tetrafluoropropene. - from 4% to 6% by weight of difluoromethane; - from 2.5% to 3.5% by weight of pentafluoroethane; and - from 91% to 93.5% by weight of tetrafluoropropene.
A whole body nuclear imaging system comprising: a patient support for receiving a patient and moving the patient in an axial direction; a gantry which includes a plurality of radiation detectors arranged circumferentially around the patient support, said radiation detectors including slit-slat collimators, wherein the gantry includes a plurality of rings (40a,40b,40c) of radiation detectors, the radiation detectors of each ring being tilted differently in the transaxial plane; and one or more processors (20,24,32) connected to the plurality of detectors for recording strikes of gamma photons in the radiation detectors and reconstructing the recorded strikes of the gamma photons into a SPECT image. a patient support for receiving a patient and moving the patient in an axial direction; a gantry which includes a plurality of radiation detectors arranged circumferentially around the patient support, said radiation detectors including slit-slat collimators, wherein the gantry includes a plurality of rings (40a,40b,40c) of radiation detectors, the radiation detectors of each ring being tilted differently in the transaxial plane; and one or more processors (20,24,32) connected to the plurality of detectors for recording strikes of gamma photons in the radiation detectors and reconstructing the recorded strikes of the gamma photons into a SPECT image.
An adhesive, comprising at least one polymer system, wherein the polymer system is obtained by a process for reducing the melt viscosity of at least one polymer blend starting material, wherein the process comprises the step of treating at least one polymer blend starting material with at least one radical donor under shear stress at a temperature above the softening point of said polymer blend starting material, which consists of: a) an elastomeric rubber or a blend of elastomeric rubbers selected from the group consisting of ethylene-propylene rubber and ethylene-propylene-diene monomer terpolymer rubber, and b) a semi-crystalline olefinic polymer or a blend of semi-crystalline olefinic polymers, wherein the semi-crystalline olefinic polymer exhibits a melting point. a) an elastomeric rubber or a blend of elastomeric rubbers selected from the group consisting of ethylene-propylene rubber and ethylene-propylene-diene monomer terpolymer rubber, and b) a semi-crystalline olefinic polymer or a blend of semi-crystalline olefinic polymers, wherein the semi-crystalline olefinic polymer exhibits a melting point.
A gateway device comprising: a security monitor to monitor a security setting status of a communication path to each of a plurality of servers (10a, 10b, 10c); a first communication unit (22a, 22b, 22c) to receive first device information that is a first piece of information transmitted from a device; a converter to convert at least a part of the first device information into second device information that is a second piece of information in a format determined depending on the servers (10a, 10b, 10c) as a transfer destination; a determination unit to determine, for each of the servers (10a, 10b, 10c), whether or not the second device information is to be transferred to the server on the basis of the security setting status of the communication path to the server; and a second communication unit to transmit the second device information to the server that is determined to be able to receive the second device information by the determination unit, said gateway device being characterized by a secret level which is preset for each device information in the format so that the determination unit determines whether or not data is to be transferred in accordance with the secret level. a security monitor to monitor a security setting status of a communication path to each of a plurality of servers (10a, 10b, 10c); a first communication unit (22a, 22b, 22c) to receive first device information that is a first piece of information transmitted from a device; a converter to convert at least a part of the first device information into second device information that is a second piece of information in a format determined depending on the servers (10a, 10b, 10c) as a transfer destination; a determination unit to determine, for each of the servers (10a, 10b, 10c), whether or not the second device information is to be transferred to the server on the basis of the security setting status of the communication path to the server; and a second communication unit to transmit the second device information to the server that is determined to be able to receive the second device information by the determination unit, said gateway device being characterized by a secret level which is preset for each device information in the format so that the determination unit determines whether or not data is to be transferred in accordance with the secret level.
An aeroponic propagator for the cultivation of plants, the aeroponic propagator comprising: a fogging system for supplying fog within the aeroponic propagator, wherein the fogging system comprises a droplet generator, the droplet generator comprising at least one outlet, and characterised in that the droplet generator is configured such that in use each at least one outlet ejects one droplet of liquid at a time.