A compound of Formula I wherein: R 1 is phenyl, optionally substituted with one or more C 1-6 alkyl, C 1-6 haloalkyl, hydroxy, hydroxy C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyl sulfonyl, halo, nitro, amino, aminoalkyl, amido, cyano, oxo, or R 1'; R 1' is heterocycloalkyl or spiro heterocycloalkyl, each optionally substituted with one or more R 1''; R 1'' is hydroxy, halo, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 haloalkyl; B is phenyl, pyridinyl, pyrrolidinyl, or piperidinyl; X is OH, C 1-6 alkoxy, NHC(=O)Y, C(=O)NH 2, C(=O)NHY, C(=O)X', C(=O)Y,CH 2 NHY, CH 2 CH 2 Y, CF=CHY, CH=CHY, CH 2 OH, C(=O)NHCH 2 CH 2 N(CH 3) 2, or C(=O)NHCH 2 CH 2 Y; X' is OH or C 1-6 alkoxy; Y is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each optionally substituted with one or more Y 3; Y 3 is hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo, oxo, C 1-6 haloalkyl, hydroxy C 1-6 alkyl, amino, amido, C(=O)NH(CH 3), C(=O)OH, C(=O)OY 4, or heteroaryl optionally substituted by with one or more C 1-6 alkyl, oxo or SH; Y 4 is C 1-6 alkyl; or a pharmaceutically acceptable salt thereof, wherein "heterocycloalkyl" denotes a monovalent saturated cyclic radical, consisting of one to two rings, including spirocyclic ring systems, of three to eight atoms per ring, incorporating one or more ring heteroatoms (chosen from N,O or S 0-2), and which can optionally be independently substituted with one or two substituents selected from hydroxy, oxo, cyano, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, alkylthio, halo, C 1-6 haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonyl, arylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, and ionic forms thereof, unless otherwise indicated; "cycloalkyl" refers to a saturated carbocyclic ring containing 3 to 8 carbon atoms; and "heteroaryl" refers to monocyclic aromatic heterocycles having 5 to 6 ring atoms and 1 to 3 heteroatoms which can optionally be substituted with one or two substituents selected from hydroxy, cyano, alkyl, alkoxy, thio, C 1-6 haloalkoxy, alkylthio, halo, C 1-6 haloalkyl, alkylsulfinyl, alkylsulfonyl, halogen, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, and dialkylaminoalkyl, nitro, alkoxycarbonyl and carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, arylcarbamoyl, alkylcarbonylamino and arylcarbonylamino. R 1 is phenyl, optionally substituted with one or more C 1-6 alkyl, C 1-6 haloalkyl, hydroxy, hydroxy C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyl sulfonyl, halo, nitro, amino, aminoalkyl, amido, cyano, oxo, or R 1'; R 1' is heterocycloalkyl or spiro heterocycloalkyl, each optionally substituted with one or more R 1''; R 1'' is hydroxy, halo, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 haloalkyl; R 1' is heterocycloalkyl or spiro heterocycloalkyl, each optionally substituted with one or more R 1''; R 1'' is hydroxy, halo, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 haloalkyl; R 1'' is hydroxy, halo, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 haloalkyl; B is phenyl, pyridinyl, pyrrolidinyl, or piperidinyl; X is OH, C 1-6 alkoxy, NHC(=O)Y, C(=O)NH 2, C(=O)NHY, C(=O)X', C(=O)Y,CH 2 NHY, CH 2 CH 2 Y, CF=CHY, CH=CHY, CH 2 OH, C(=O)NHCH 2 CH 2 N(CH 3) 2, or C(=O)NHCH 2 CH 2 Y; X' is OH or C 1-6 alkoxy; Y is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each optionally substituted with one or more Y 3; Y 3 is hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo, oxo, C 1-6 haloalkyl, hydroxy C 1-6 alkyl, amino, amido, C(=O)NH(CH 3), C(=O)OH, C(=O)OY 4, or heteroaryl optionally substituted by with one or more C 1-6 alkyl, oxo or SH; Y 4 is C 1-6 alkyl; X' is OH or C 1-6 alkoxy; Y is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each optionally substituted with one or more Y 3; Y 3 is hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo, oxo, C 1-6 haloalkyl, hydroxy C 1-6 alkyl, amino, amido, C(=O)NH(CH 3), C(=O)OH, C(=O)OY 4, or heteroaryl optionally substituted by with one or more C 1-6 alkyl, oxo or SH; Y 4 is C 1-6 alkyl; Y 3 is hydroxy, C 1-6 alkyl, C 1-6 alkoxy, halo, oxo, C 1-6 haloalkyl, hydroxy C 1-6 alkyl, amino, amido, C(=O)NH(CH 3), C(=O)OH, C(=O)OY 4, or heteroaryl optionally substituted by with one or more C 1-6 alkyl, oxo or SH; Y 4 is C 1-6 alkyl; Y 4 is C 1-6 alkyl;