Use of a syringe comprising: • a syringe barrel, comprising a thermoplastic wall having an interior surface enclosing at least a portion of a lumen, an exterior surface, and a coating set on at least one of the interior surface and the exterior surface of the wall, the coating set comprising: o a tie coating or layer on the interior surface or the exterior surface comprising SiO x C y H z in which x is from about 0.5 to about 2.4 as measured by X-ray photoelectron spectroscopy, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of Rutherford backscattering spectrometry or hydrogen forward scattering, the tie coating or layer having a facing surface facing toward the wall, the tie coating or layer also having an opposed surface facing away from the wall; ∘ a barrier coating or layer of SiO x, in which x is from about 1.5 to about 2.9 as measured by XPS, the barrier coating or layer having a facing surface facing toward the opposed surface of the tie coating or layer and an opposed surface facing away from the tie coating or layer; ∘ optionally, a pH protective coating or layer of SiO x C y H z, in which x is from about 0.5 to about 2.4 as measured by XPS, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of RBS or HFS, the pH protective coating or layer, if present, having a facing surface facing toward the opposed surface of the barrier layer and an opposed surface facing away from the barrier layer; and ∘ a lubricity coating or layer positioned between the pH protective coating or layer and the lumen; and • a closure, for example a plunger or stopper, seated in the lumen having a front face facing the liquid formulation, as a pre-filled syringe for storing in the lumen a liquid formulation of an ophthalmic drug suitable for intravitreal injection, and thereby achieving that the ophthalmic drug suitable for intravitreal injection meets the particle count standard for particulate matter in ophthalmic solutions of USP789 as in force on November 1, 2015, or Ph. Eur. 5.7.1 as in force on November 1, 2015, or both after three months of storage of the pre-filled syringe at 4-8°C, alternatively after three months of storage of the pre-filled syringe at 25°C and 60% relative humidity, alternatively after three months of storage of the pre-filled syringe at 40°C and 75% relative humidity. • a syringe barrel, comprising a thermoplastic wall having an interior surface enclosing at least a portion of a lumen, an exterior surface, and a coating set on at least one of the interior surface and the exterior surface of the wall, the coating set comprising: o a tie coating or layer on the interior surface or the exterior surface comprising SiO x C y H z in which x is from about 0.5 to about 2.4 as measured by X-ray photoelectron spectroscopy, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of Rutherford backscattering spectrometry or hydrogen forward scattering, the tie coating or layer having a facing surface facing toward the wall, the tie coating or layer also having an opposed surface facing away from the wall; ∘ a barrier coating or layer of SiO x, in which x is from about 1.5 to about 2.9 as measured by XPS, the barrier coating or layer having a facing surface facing toward the opposed surface of the tie coating or layer and an opposed surface facing away from the tie coating or layer; ∘ optionally, a pH protective coating or layer of SiO x C y H z, in which x is from about 0.5 to about 2.4 as measured by XPS, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of RBS or HFS, the pH protective coating or layer, if present, having a facing surface facing toward the opposed surface of the barrier layer and an opposed surface facing away from the barrier layer; and ∘ a lubricity coating or layer positioned between the pH protective coating or layer and the lumen; and o a tie coating or layer on the interior surface or the exterior surface comprising SiO x C y H z in which x is from about 0.5 to about 2.4 as measured by X-ray photoelectron spectroscopy, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of Rutherford backscattering spectrometry or hydrogen forward scattering, the tie coating or layer having a facing surface facing toward the wall, the tie coating or layer also having an opposed surface facing away from the wall; ∘ a barrier coating or layer of SiO x, in which x is from about 1.5 to about 2.9 as measured by XPS, the barrier coating or layer having a facing surface facing toward the opposed surface of the tie coating or layer and an opposed surface facing away from the tie coating or layer; ∘ optionally, a pH protective coating or layer of SiO x C y H z, in which x is from about 0.5 to about 2.4 as measured by XPS, y is from about 0.6 to about 3 as measured by XPS, and z is from about 2 to about 9 as measured by at least one of RBS or HFS, the pH protective coating or layer, if present, having a facing surface facing toward the opposed surface of the barrier layer and an opposed surface facing away from the barrier layer; and ∘ a lubricity coating or layer positioned between the pH protective coating or layer and the lumen; and • a closure, for example a plunger or stopper, seated in the lumen having a front face facing the liquid formulation,