A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature T b and for stabilizing said body temperature at said target temperature T b, said system comprising: - a thermally insulated cabinet for receiving said individual, equipped with channeling means to channel fluids into the body of said individual; - at least one thermal means, configured to raise said body temperature of said individual, when placed inside said cabinet, and to subsequently maintain the target temperature T b of said individual; - one or more devices for heating fluids to be channeled into the body of said individual via said channeling means; - one or more sensors configured to monitor the temperature and/or heat flux of said individual, when placed inside said cabinet; and - a controller configured to control said at least one thermal means and said one or more devices for heating fluids; wherein said one or more sensors are connected to said controller so as to provide monitored temperature values and/or said monitored heat flux values to said controller; wherein said at least one thermal means comprises means for heating air and injecting said heated air into said cabinet so as to impact on the body of said individual; wherein said system further comprises means for monitoring blood parameters, wherein said monitored blood parameters comprise one or more of pH, PO2, PCO2, salts, lactate concentration, blood sugar, hematocrit values, CPK, and dissolved gases; and wherein said system further comprises a heat exchanger for local application, configured for circulating a heating or cooling fluid, and means to bring said heating or cooling fluid to a set temperature T f, wherein T f = T b ± 0.5 K. - a thermally insulated cabinet for receiving said individual, equipped with channeling means to channel fluids into the body of said individual; - at least one thermal means, configured to raise said body temperature of said individual, when placed inside said cabinet, and to subsequently maintain the target temperature T b of said individual; - one or more devices for heating fluids to be channeled into the body of said individual via said channeling means; - one or more sensors configured to monitor the temperature and/or heat flux of said individual, when placed inside said cabinet; and - a controller configured to control said at least one thermal means and said one or more devices for heating fluids; wherein said one or more sensors are connected to said controller so as to provide monitored temperature values and/or said monitored heat flux values to said controller; wherein said at least one thermal means comprises means for heating air and injecting said heated air into said cabinet so as to impact on the body of said individual; wherein said system further comprises means for monitoring blood parameters, wherein said monitored blood parameters comprise one or more of pH, PO2, PCO2, salts, lactate concentration, blood sugar, hematocrit values, CPK, and dissolved gases; and wherein said system further comprises a heat exchanger for local application, configured for circulating a heating or cooling fluid, and means to bring said heating or cooling fluid to a set temperature T f, wherein T f = T b ± 0.5 K.