Method comprising the steps of: - providing a library of antibodies and/or antibody fragments - introducing the antibodies and/or antibody fragments to a selection method, the selection method comprising at least two selection cycles, a first selection cycle and a second selection cycle - sequencing the genes of the antibodies and/or antibody fragments after the first selection cycle and after the second selection cycle and ascertaining V L genes encoding the variable domains of light chains of the antibodies and/or antibody fragments and V H genes encoding the variable domains of the heavy chains of the antibodies and/or antibody fragments - ascertaining features relating to the V L genes and V H genes from the first selection method and from the second selection method, the features relating to the V L genes and V H genes comprising the following features: • unambiguous identifiers of the ascertained V H genes, • unambiguous identifiers of the ascertained V L genes, • counts of the V H genes in the pool from the second selection cycle, • counts of the V L genes in the pool from the second selection cycle, • the counts of the V H genes in the pool from the first selection cycle, and • the counts of the V L genes in the pool from the first selection cycle - forming feature vectors for pairs of V L genes and V H genes from the second selection cycle on the basis of the ascertained features from the first selection cycle and the second selection cycle - introducing the feature vectors to a classification model which performs for the respective pairs a classification into one of at least two classes, a first class encompassing pairs in which the V L gene and the V H gene encode variable domains which belong to the same antibody and/or antibody fragment and a second class encompassing pairs in which the V L gene and the V H gene encode variable domains which do not belong to the same antibody and/or antibody fragment - outputting information at least in relation to pairs in the first class. - providing a library of antibodies and/or antibody fragments - introducing the antibodies and/or antibody fragments to a selection method, the selection method comprising at least two selection cycles, a first selection cycle and a second selection cycle - sequencing the genes of the antibodies and/or antibody fragments after the first selection cycle and after the second selection cycle and ascertaining V L genes encoding the variable domains of light chains of the antibodies and/or antibody fragments and V H genes encoding the variable domains of the heavy chains of the antibodies and/or antibody fragments - ascertaining features relating to the V L genes and V H genes from the first selection method and from the second selection method, the features relating to the V L genes and V H genes comprising the following features: • unambiguous identifiers of the ascertained V H genes, • unambiguous identifiers of the ascertained V L genes, • counts of the V H genes in the pool from the second selection cycle, • counts of the V L genes in the pool from the second selection cycle, • the counts of the V H genes in the pool from the first selection cycle, and • the counts of the V L genes in the pool from the first selection cycle • unambiguous identifiers of the ascertained V H genes, • unambiguous identifiers of the ascertained V L genes, • counts of the V H genes in the pool from the second selection cycle, • counts of the V L genes in the pool from the second selection cycle, • the counts of the V H genes in the pool from the first selection cycle, and • the counts of the V L genes in the pool from the first selection cycle - forming feature vectors for pairs of V L genes and V H genes from the second selection cycle on the basis of the ascertained features from the first selection cycle and the second selection cycle - introducing the feature vectors to a classification model which performs for the respective pairs a classification into one of at least two classes, a first class encompassing pairs in which the V L gene and the V H gene encode variable domains which belong to the same antibody and/or antibody fragment and a second class encompassing pairs in which the V L gene and the V H gene encode variable domains which do not belong to the same antibody and/or antibody fragment - outputting information at least in relation to pairs in the first class.