A compound of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: A is phenyl which may be substituted with one of chloro, fluoro, or methyl; W is pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, or furanyl, any of which may be connected through any carbon atom, wherein the pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, or furanyl may contain one -Cl, -CN, -NO 2, -OMe, or -CF 3 substitution, connected to any other carbon; R 2 is cycloalkyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, and C alkyl, with the proviso that tetrahydropyridyl is connected to the ring A through a carbon-carbon bond; wherein the term "cycloalkyl" refers to a saturated or partially unsaturated ring composed of from 3 to 8 carbon atoms; X is and is attached to the phenyl A ring para to the nitrogen substituent, as depicted in Formula II: Z is CH or N; D 1 and D 2 are each hydrogen or taken together form a double bond to an oxygen: D 3 and D 4 are hydrogen; E is N or SO 2, with the proviso that E may not be N if the following three conditions are simultaneously met: Q a is absent, Q b is absent, and R 3 is an amino group or cyclic amino radical wherein the point of attachment to E is N; Q a is absent, -CH 2 -, -CH 2 CH 2 -, or -C -; Q b is absent, -NH-, -CH 2 -, -CH 2 CH 2 -, or -C -, with the proviso that Q b may not be C if Q a is C, and further provided that Q b may not be -NH- if E is N and Q a is absent, further provided that Q b may not be -NH- if R 3 is an amino group or cyclic amino radical wherein the point of attachment to Q b is N; R 3 is hydrogen, piperidinyl, alkylamino, dialkylamino, hydroxyalkylamino, (hydroxyalkyl) 2 amino, imidazolyl, 1-methyl imidazolyl, pyridyl, pyridyl N-oxide, hydroxyalkyl, -COOH, -CONH 2, -CN, -SO 2 CH 3, -NH 2, morpholinyl; R 3 may also be absent, with the proviso that R 3 is not absent when E is nitrogen. A is phenyl which may be substituted with one of chloro, fluoro, or methyl; W is pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, or furanyl, any of which may be connected through any carbon atom, wherein the pyrrolyl, imidazolyl, isoxazolyl, oxazolyl, or furanyl may contain one -Cl, -CN, -NO 2, -OMe, or -CF 3 substitution, connected to any other carbon; R 2 is cycloalkyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, and C alkyl, with the proviso that tetrahydropyridyl is connected to the ring A through a carbon-carbon bond; wherein the term "cycloalkyl" refers to a saturated or partially unsaturated ring composed of from 3 to 8 carbon atoms; X is and is attached to the phenyl A ring para to the nitrogen substituent, as depicted in Formula II: Z is CH or N; D 1 and D 2 are each hydrogen or taken together form a double bond to an oxygen: D 3 and D 4 are hydrogen; E is N or SO 2, with the proviso that E may not be N if the following three conditions are simultaneously met: Q a is absent, Q b is absent, and R 3 is an amino group or cyclic amino radical wherein the point of attachment to E is N; Q a is absent, -CH 2 -, -CH 2 CH 2 -, or -C -; Q b is absent, -NH-, -CH 2 -, -CH 2 CH 2 -, or -C -, with the proviso that Q b may not be C if Q a is C, and further provided that Q b may not be -NH- if E is N and Q a is absent, further provided that Q b may not be -NH- if R 3 is an amino group or cyclic amino radical wherein the point of attachment to Q b is N; R 3 is hydrogen, piperidinyl, alkylamino, dialkylamino, hydroxyalkylamino, (hydroxyalkyl) 2 amino, imidazolyl, 1-methyl imidazolyl, pyridyl, pyridyl N-oxide, hydroxyalkyl, -COOH, -CONH 2, -CN, -SO 2 CH 3, -NH 2, morpholinyl; R 3 may also be absent, with the proviso that R 3 is not absent when E is nitrogen.