mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula wherein A is or where the dotted line represents an optional double bond; X is a -(CR 7 R 8) m -, Y and Z are independently -O-, -NR 6 - or are absent; V is -N- or -CH-; W is -CH- or -N-; R 1 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted arylalkyl or optionally substituted aryl; R 2 and R 3 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl; R 4 is hydrogen or optionally substituted alkyl; R 6 is hydrogen or optionally substituted alkyl, optionally substituted cycloalkyl; R 7 and R 8 are independently hydrogen, halogen or optionally substituted alkyl; R 9 and R 10 are independently hydrogen, halogen or optionally substituted alkyl, or R 9 and R 10 can be taken together to form a ring; R 11, R 12, R 13 and R 14 are independently hydrogen, halogen, optionally substituted alkyl or OR 15; R 15 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q is 0, 1, 2, 3, or 4; r is 0 or 1; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. A is or where the dotted line represents an optional double bond; X is a -(CR 7 R 8) m -, Y and Z are independently -O-, -NR 6 - or are absent; V is -N- or -CH-; W is -CH- or -N-; R 1 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted arylalkyl or optionally substituted aryl; R 2 and R 3 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl or optionally substituted heterocycloalkyl; R 4 is hydrogen or optionally substituted alkyl; R 6 is hydrogen or optionally substituted alkyl, optionally substituted cycloalkyl; R 7 and R 8 are independently hydrogen, halogen or optionally substituted alkyl; R 9 and R 10 are independently hydrogen, halogen or optionally substituted alkyl, or R 9 and R 10 can be taken together to form a ring; R 11, R 12, R 13 and R 14 are independently hydrogen, halogen, optionally substituted alkyl or OR 15; R 15 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; m and n are independently 0, 1, 2, 3, or 4; o and p are independently 0, 1, 2 or 3; q is 0, 1, 2, 3, or 4; r is 0 or 1; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
A surgical instrument for implanting an implantable material to treat incontinence, the instrument comprising: a handle, a needle extending from the handle, the needle comprising a spacer portion connected to the handle, and a three-dimensional region connected to the spacer portion distal from the handle, and having structure in three dimensions including a needle distal end at the distal end of the three-dimensional region, wherein the needle portion is sized and shaped to extend between an incision substantially adjacent to a patient's obturator foramen, through the obturator foramen, and to a medial incision; the three-dimensional region has a length in the range from 58.4 to 127 mm (2.3 to 5 inches) and a diameter in the range from 58.4 to 127 mm (2.3 to 5 inches), and an axis of the needle end portion lies within a plane that is orthogonal to the longitudinal axis of the tool, characterised in that an angle between an axis of the needle end portion and a tangent at said end portion of a circle having an origin at the longitudinal axis and a radius extending to the needle distal end, when viewed along the longitudinal axis, is up to 15 degrees. a handle, a needle extending from the handle, the needle comprising a spacer portion connected to the handle, and a three-dimensional region connected to the spacer portion distal a needle extending from the handle, the needle comprising a spacer portion connected to the handle, and a three-dimensional region connected to the spacer portion distal from the handle, and having structure in three dimensions including a needle distal end at the distal end of the three-dimensional region, wherein the needle portion is sized and shaped to extend between an incision substantially adjacent to a patient's obturator foramen, through the obturator foramen, and to a medial incision; the three-dimensional region has a length in the range from 58.4 to 127 mm (2.3 to 5 inches) and a diameter in the range from 58.4 to 127 mm (2.3 to 5 inches), and an axis of the needle end portion lies within a plane that is orthogonal to the longitudinal axis of the tool, characterised in that an angle between an axis of the needle end portion and a tangent at said end portion of a circle having an origin at the longitudinal axis and a radius extending to the needle distal end, when viewed along the longitudinal axis, is up to 15 degrees. the needle portion is sized and shaped to extend between an incision substantially adjacent to a patient's obturator foramen, through the obturator foramen, and to a medial incision; the three-dimensional region has a length in the range from 58.4 to 127 mm (2.3 to 5 inches) and a diameter in the range from 58.4 to 127 mm (2.3 to 5 inches), and an axis of the needle end portion lies within a plane that is orthogonal to the longitudinal axis of the tool, characterised in that an angle between an axis of the needle end portion and a tangent at said end portion of a circle having an origin at the longitudinal axis and a radius extending to the needle distal end, when viewed along the longitudinal axis, is up to 15 degrees.
A receiver for a self-loading firearm which has a breech block guided in a longitudinally movable manner in the receiver, with: a first guide track within which a loading lever is movable to move a loading tube that can be brought into contact with, or is in contact with, the breech block, wherein the receiver has a second guide track connected to the first guide track via a first opening in the receiver, within which the loading lever is movable to move the loading tube, such that the loading lever can be operated either on the left or on the right side in order to load the self-loading firearm.
A sole for an article of footwear, the sole comprising: a. a fiber-reinforced polymer plate extending from a heel area of the article of footwear to a toe area of the article of footwear, wherein a flexibility of the fiber-reinforced polymer plate varies as a function of a location along a longitudinal axis of the fiber-reinforced polymer plate, and wherein the fiber-reinforced polymer plate comprises a stiffening layer disposed at a midfoot area of the fiber-reinforced polymer plate; and b. a midsole support coupled to the fiber-reinforced polymer plate, wherein the midsole support extends around a peripheral edge of the fiber-reinforced polymer plate and wherein a continuous portion of the midsole support covers two portions of the peripheral edge spaced apart by an uncovered portion of the peripheral edge, wherein the midsole support defines a serpentine shape along the peripheral edge of the fiber-reinforced polymer plate, and wherein the midsole support extends above and below the fiber-reinforced polymer plate. a. a fiber-reinforced polymer plate extending from a heel area of the article of footwear to a toe area of the article of footwear, wherein a flexibility of the fiber-reinforced polymer plate varies as a function of a location along a longitudinal axis of the fiber-reinforced polymer plate, and wherein the fiber-reinforced polymer plate comprises a stiffening layer disposed at a midfoot area of the fiber-reinforced polymer plate; and wherein a flexibility of the fiber-reinforced polymer plate varies as a function of a location along a longitudinal axis of the fiber-reinforced polymer plate, and wherein the fiber-reinforced polymer plate comprises a stiffening layer disposed at a midfoot area of the fiber-reinforced polymer plate; and b. a midsole support coupled to the fiber-reinforced polymer plate, wherein the midsole support extends around a peripheral edge of the fiber-reinforced polymer plate and wherein a continuous portion of the midsole support covers two portions of the peripheral edge spaced apart by an uncovered portion of the peripheral edge, wherein the midsole support defines a serpentine shape along the peripheral edge of the fiber-reinforced polymer plate, and wherein the midsole support extends above and below the fiber-reinforced polymer plate. wherein the midsole support extends around a peripheral edge of the fiber-reinforced polymer plate and wherein a continuous portion of the midsole support covers two portions of the peripheral edge spaced apart by an uncovered portion of the peripheral edge, wherein the midsole support defines a serpentine shape along the peripheral edge of the fiber-reinforced polymer plate, and wherein the midsole support extends above and below the fiber-reinforced polymer plate.
Electrochemical precipitation reactor comprising an electrically conductive electrode, - wherein the electrode comprises an area electrode having a two-dimensional extension which gets into contact with a liquid to be treated in the precipitation reactor, - wherein the area electrode includes a plastic matrix, wherein the area electrode has a smooth surface (56, 57) there, where it gets into contact with the liquid to be treated in the precipitation reactor, characterized in - that the plastic matrix is based on a thermoplastic elastomer and forms the smooth surface (56, 57), - that electrically conductive particles embedded in the plastic matrix are based on carbon, and - that the particles have a particle size of up to 1000 μm. - wherein the electrode comprises an area electrode having a two-dimensional extension which gets into contact with a liquid to be treated in the precipitation reactor, - wherein the area electrode includes a plastic matrix, wherein the area electrode has a smooth surface (56, 57) there, where it gets into contact with the liquid to be treated in the precipitation reactor, - that the plastic matrix is based on a thermoplastic elastomer and forms the smooth surface (56, 57), - that electrically conductive particles embedded in the plastic matrix are based on carbon, and - that the particles have a particle size of up to 1000 μm.
An arrangement for splitting an animal carcass along its spine, with an inner and/or outer guide device adjustable along the spine, which guide device has two skid elements (16, 18, 116, 118) extending at a distance from one another and which can be applied in the spine region of the animal carcass, and two roller elements (21, 23), characterized in that the inner and/or outer guide device comprises both the two skid elements (16, 18, 116, 118) extending at a distance from one another and the two roller elements (21, 23), which are arranged as extensions of the skid elements (16, 18, 116, 118).
An encoding method for a multi-channel audio signal encoding, the method being performed by an audio encoder and comprising: obtaining a plurality of audio signal channels; and coordinating a selection of an encoding mode for the plurality of the obtained channels, wherein the coordination is based on an encoding mode selected for one of the obtained channels, and wherein the coordination is selectively activated. obtaining a plurality of audio signal channels; and coordinating a selection of an encoding mode for the plurality of the obtained channels, wherein the coordination is based on an encoding mode selected for one of the obtained channels, and wherein the coordination is selectively activated.
An implantable tissue connector adapted so as to be connectable to a tubular part of living tissue within a patient's body, comprising a conduit having at least a first end and a second end and further having an outer surface, and at least one flexible sleeve adapted to axially extend and closely fit around at least part of said outer surface of the conduit, said flexible sleeve is mounted on said outer surface either folded or rolled upon itself so that it can be unfolded or unrolled, or said flexible sleeve is mounted on said outer surface so as to be foldable upon itself; characterised in that the flexible sleeve comprises a porous ingrowth layer allowing ingrowth of living tissue.
Endoscopic medical device comprising a main body, cylindrical with respect to a main extension axis (X-X), which extends from a proximal end to a distal end, said main body being hollow so as to delimit a cavity adapted to at least partially house a distal portion of an endoscope which can be associated therewith, on the side of said proximal end of the main body, said main body, at an outer side wall, opposite to said cavity, having a plurality of flexible fins provided with arms which, in a resting condition, extend along main directions (Y-Y) incident with said main extension axis (X-X) according to an opening angle (α) comprised between 10 and 55 degrees, measured from the side of the distal end, wherein said arms are engaged with the outer side wall at fixing ends for fixing to the main body, said endoscopic medical device being characterized in that said arms, at cantilevered ends opposite to the fixing ends, branch into pairs of branches (52,56), arranged symmetrically with respect to a centerline plane (M-M) passing through said arms and through said main extension axis (X-X). said main body being hollow so as to delimit a cavity adapted to at least partially house a distal portion of an endoscope which can be associated therewith, on the side of said proximal end of the main body, said main body, at an outer side wall, opposite to said cavity, having a plurality of flexible fins provided with arms which, in a resting condition, extend along main directions (Y-Y) incident with said main extension axis (X-X) according to an opening angle (α) comprised between 10 and 55 degrees, measured from the side of the distal end, wherein said arms are engaged with the outer side wall at fixing ends for fixing to the main body, said endoscopic medical device being characterized in that said arms, at cantilevered ends opposite to the fixing ends, branch into pairs of branches (52,56), arranged symmetrically with respect to a centerline plane (M-M) passing through said arms and through said main extension axis (X-X).
A method for initiating a data connection between a central server and a control unit communicatively coupled to an elevator, escalator or autowalk, characterized in that the method comprising: receiving a trigger signal in the control unit from the central server, wherein the trigger signal is delivered with a voice call service or a messaging service of a mobile communication network i to which the control unit is communicatively coupled, detecting if the trigger signal complies with at least one pre-defined requirement, and in response to a positive outcome of the detection initiating an IP based data connection establishment from the control unit to the central server by instructing, by the control unit, a transceiver equipped with a subscription of the mobile communication network to establish the IP based data connection. receiving a trigger signal in the control unit from the central server, wherein the trigger signal is delivered with a voice call service or a messaging service of a mobile communication network i to which the control unit is communicatively coupled, detecting if the trigger signal complies with at least one pre-defined requirement, and in response to a positive outcome of the detection initiating an IP based data connection establishment from the control unit to the central server by instructing, by the control unit, a transceiver equipped with a subscription of the mobile communication network to establish the IP based data connection.
A computer-implemented method of reconciling values of a feature, each value of the feature being provided by a different artificial intelligence, AI, system, the method comprising: collecting logs from the different AI systems, each log including a value of the feature; identifying any discrepancy between the values of the feature, and when there is any discrepancy: creating global information from the values of the feature provided by the different AI systems, the global information taking into account some or all of the values of the feature, and when the global information differs from the value of the feature of one of the AI systems: sending the global information to that AI system, wherein the AI systems determine a position of an object or identify an object, and the feature is a determined position of an object, or an identification of an object. collecting logs from the different AI systems, each log including a value of the feature; identifying any discrepancy between the values of the feature, and when there is any discrepancy: creating global information from the values of the feature provided by the different AI systems, the global information taking into account some or all of the values of the feature, and when the global information differs from the value of the feature of one of the AI systems: sending the global information to that AI system, wherein the AI systems determine a position of an object or identify an object, and the feature is a determined position of an object, or an identification of an object.
A computer implemented method for determining tubular wear volume, the method comprising: determining a stretch factor of an inner tubular string positioned inside an outer tubular string, wherein the stretch factor comprises a tubular stretch correction for operational conditions that result in an elongation of the inner tubing string; determining a wear factor along the outer tubular string based upon the stretch factor; determining the tubular wear volume based upon the wear factor, the tubular wear volume being an amount of outer tubing string material removed by wear caused by the inner tubular string; and designing a drill string based upon the tubular wear volume; or adjusting a drilling operation in real-time based upon the tubular wear volume. determining a stretch factor of an inner tubular string positioned inside an outer tubular string, wherein the stretch factor comprises a tubular stretch correction for operational conditions that result in an elongation of the inner tubing string; determining a wear factor along the outer tubular string based upon the stretch factor; determining the tubular wear volume based upon the wear factor, the tubular wear volume being an amount of outer tubing string material removed by wear caused by the inner tubular string; and designing a drill string based upon the tubular wear volume; or adjusting a drilling operation in real-time based upon the tubular wear volume.
A solid oral dosage form comprising about 0.5 mg estradiol and about 0.25 mg drospirenone, and at least one pharmaceutically acceptable excipient for use as a medicament.
Method of MR imaging of an object positioned in an examination volume of a MR device, the method comprising the steps of: - subjecting the object to an imaging sequence comprising: a) gradually varying a magnetic field gradient vector (GX, GY, GZ) from an initial position to an end position over a plurality of intermediate positions while a number of RF pulses is radiated in the presence of the magnetic field gradient; b) gradually varying the magnetic field gradient vector (GX, GY, GZ) again from the initial position to the end position over the plurality of intermediate positions while a number of MR echo signals is acquired in the presence of the magnetic field gradient; c) sampling a spherical volume in k-space by repeating steps a) and b) a number of times for different initial and end positions and/or trajectories of the magnetic field gradient vector; - reconstructing a MR image from the acquired MR echo signals. - subjecting the object to an imaging sequence comprising: a) gradually varying a magnetic field gradient vector (GX, GY, GZ) from an initial position to an end position over a plurality of intermediate positions while a number of RF pulses is radiated in the presence of the magnetic field gradient; b) gradually varying the magnetic field gradient vector (GX, GY, GZ) again from the initial position to the end position over the plurality of intermediate positions while a number of MR echo signals is acquired in the presence of the magnetic field gradient; c) sampling a spherical volume in k-space by repeating steps a) and b) a number of times for different initial and end positions and/or trajectories of the magnetic field gradient vector; a) gradually varying a magnetic field gradient vector (GX, GY, GZ) from an initial position to an end position over a plurality of intermediate positions while a number of RF pulses is radiated in the presence of the magnetic field gradient; b) gradually varying the magnetic field gradient vector (GX, GY, GZ) again from the initial position to the end position over the plurality of intermediate positions while a number of MR echo signals is acquired in the presence of the magnetic field gradient; c) sampling a spherical volume in k-space by repeating steps a) and b) a number of times for different initial and end positions and/or trajectories of the magnetic field gradient vector; - reconstructing a MR image from the acquired MR echo signals.
A shift by wire gear shift actuator comprising a selector knob, rotatable for selecting one of a number of gearshift positions among at least Park, Reverse, Neutral, and Drive gearshift positions (P, R, N, D) for controlling a vehicle transmission, and a display arrangement associated with the selector knob, the display arrangement comprising display units arranged to be sequentially switched on according to said different gearshift positions (P, R, N, D) for sequentially and dynamically providing optical indications according to said gearshift positions (P, R, N, D) having the effect of simulating a rotational movement of the selector knob informing the user that the vehicle transmission is being automatically driven into the Park gearshift position when a determined condition is met, characterized in that the display units in the display arrangement are arranged as a progress band located on the selector knob in the form of cursors configured to switch on and off alternatively around the selector knob for sequentially displaying different gearshift positions (P, R, N, D).
Cooling arrangement for a utility vehicle comprising a hood which together with a frame element and a driver's cabin forms a cooling chamber, wherein the cooling chamber is divided by means of a separating element into a radiator compartment and an engine compartment, and the hood comprises at least one opening for drawing cool external ambient air into the radiator compartment, and a heat exchange unit is arranged in the radiator compartment, wherein a connecting duct connects a region of the radiator compartment, which precedes the heat exchange unit, to the engine compartment, characterised in that a cavity formed between the heat exchange unit and the separating element is connected to external ambient air by at least one first outlet arranged in the hood transversely to the direction of travel of the utility vehicle