A system for secure ultrasound treatment of living tissues, said system comprising providing: - an ultrasound probe comprising a reflective cavity able to be in acoustic communication with living tissues to transmit ultrasound wave to said living tissues, at least one transducer (6, 6a) able to emit an ultrasound wave in the reflective cavity and at least one transducer (6, 6b) able to acquire a backscattered signal in the reflective cavity, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to emit at least one first ultrasound wave in the reflective cavity, said first ultrasound wave generating a backscattered ultrasound wave in the reflective cavity, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to acquire a backscattered signal in response to the backscattered ultrasound wave in the reflective cavity, characterized in that it further comprises: - means for determining whether an insonification can be safely performed by: o computing a similarity value between said backscattered signal and a predefined reference signal, o comparing said similarity value with a security threshold to determine whether an insonification can be safely performed, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to emit at least one second ultrasound wave in the reflective cavity if it is determined that an insonification can be safely performed, treating the living tissues, said at least one second ultrasound wave being transmitted to the living tissues, focused on at least one target point of the living tissues and generating a pressure pulse sufficient to result in cavitation at said at least one target point. - an ultrasound probe comprising a reflective cavity able to be in acoustic communication with living tissues to transmit ultrasound wave to said living tissues, at least one transducer (6, 6a) able to emit an ultrasound wave in the reflective cavity and at least one transducer (6, 6b) able to acquire a backscattered signal in the reflective cavity, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to emit at least one first ultrasound wave in the reflective cavity, said first ultrasound wave generating a backscattered ultrasound wave in the reflective cavity, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to acquire a backscattered signal in response to the backscattered ultrasound wave in the reflective cavity, - means for determining whether an insonification can be safely performed by: o computing a similarity value between said backscattered signal and a predefined reference signal, o comparing said similarity value with a security threshold to determine whether an insonification can be safely performed, o computing a similarity value between said backscattered signal and a predefined reference signal, o comparing said similarity value with a security threshold to determine whether an insonification can be safely performed, - means for controlling at least one transducer (6, 6a) of the ultrasound probe to emit at least one second ultrasound wave in the reflective cavity if it is determined that an insonification can be safely performed, treating the living tissues, said at least one second ultrasound wave being transmitted to the living tissues, focused on at least one target point of the living tissues and generating a pressure pulse sufficient to result in cavitation at said at least one target point.