A compound of Formula: wherein: X is a C 1-6 alkylene substituted with 0, 1, or 2 R 7b; R 1 is an Arginine mimetic moiety selected from the group consisting of R 2 is hydrogen or C 1-6 alkyl; R 3 is selected from the group consisting from hydrogen, or R 2 and R 3 taken together with the atom to which they are attached form a carbocyclyl or a heterocyclyl, wherein the carbocyclyl and heterocyclyl are each independently substituted with 0, 1, 2, or 3 R 12; R 4 is hydrogen; R 5 is H or R 5a; and R 5a is methyl, ethyl, isopropyl, n -butyl, isopentyl, or a structural moiety selected from R 7b is each independently halo, cyano, hydroxyl, amino, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide; R 12, is independently halo, cyano, nitro, OH, amino, C 1-6 alkyl, alkoxy, aminoalkyl, haloalkyl, haloalkoxy, haloaminoalkyl, 3 to 6 membered carbocyclyl, or 3 to 6 membered heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl; wherein the aryl and heteroaryl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, and sulfonamide; and the carbocyclyl and heterocyclyl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, oxo, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide; or a pharmaceutically acceptable salt thereof. X is a C 1-6 alkylene substituted with 0, 1, or 2 R 7b; R 1 is an Arginine mimetic moiety selected from the group consisting of R 2 is hydrogen or C 1-6 alkyl; R 3 is selected from the group consisting from hydrogen, or R 2 and R 3 taken together with the atom to which they are attached form a carbocyclyl or a heterocyclyl, wherein the carbocyclyl and heterocyclyl are each independently substituted with 0, 1, 2, or 3 R 12; R 4 is hydrogen; R 5 is H or R 5a; and R 5a is methyl, ethyl, isopropyl, n -butyl, isopentyl, or a structural moiety selected from R 7b is each independently halo, cyano, hydroxyl, amino, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide; R 12, is independently halo, cyano, nitro, OH, amino, C 1-6 alkyl, alkoxy, aminoalkyl, haloalkyl, haloalkoxy, haloaminoalkyl, 3 to 6 membered carbocyclyl, or 3 to 6 membered heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl; wherein the aryl and heteroaryl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, and sulfonamide; and the carbocyclyl and heterocyclyl, by themselves or as part of another group, are each independently substituted with one or more groups independently selected from halo, cyano, hydroxyl, amino, oxo, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, haloalkoxy, amido, carbamate, or sulfonamide; or a pharmaceutically acceptable salt thereof.