A compound of Formula or a pharmaceutically acceptable salt thereof wherein R 1 is H or -CH 3; R 2 is H or -CH 3; R 3 is H, -C 1 -C 5 alkyl, -OCH 3, or -O-C 1 -C 3 haloalkyl; R 4 is H or -CH 3; moiety is R aa is H or -CH 3; R bb is H, -CH 3 or -CF 3; R cc is -CH 3, -CD 3 or -CH 2 CF 3; moiety is E is N or CH; F is O, S, NH or NCH 3; R a is H or -CH 3; R b is H, D, -OH, F, -C 1 -C 5 alkyl, -CH 2 OCH 3, -C 1 -C 5 haloalkyl, -NH 2, cyclopropyl, or -CH 2 OH; R c is H, D or -CH 3; R d is H, -CN, -CF 3, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, -O-C 1 -C 3 alkyl, -N(R 6)R 7, wherein R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3, -COCH 3, -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R e is H, -CD 3, Br, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, or -C 1 -C 5 alkyl substituted with 1 to 3 R g groups, wherein R g is -NH 2, or F; R 10 is H orF; R 11 is H or F; R f is H, -CH 3 or R h is -CH 3, -NH 2 or R i is H, -CH 3, -CN, Br, R j is -NH 2 or R k is H, -CF 3, I, Cl, Br, -CN, -C 1 -C 6 alkyl, R 12 is H or -CH 3; R 13 is H, -CH 3, -CH 2 (CH 3) 2 OH, -(CH 2) 3 CN, or -(CH 2) 2 NH 2; R 14 is H or -CH 3; R l is H, -C 1 -C 4 alkyl, -CF 3, R m is H or -CH 3; R n is -NH 2; R o is H or -CH 3; R p is H or -CH 3; R q is H, -CN, F, Cl, -OCH 3, -CF 3, or -CH 3; and R s is -NH 2 or provided that when moiety is and each R 1, R 2, R 3 and R 4 is H, then moiety is R 1 is H or -CH 3; R 2 is H or -CH 3; R 3 is H, -C 1 -C 5 alkyl, -OCH 3, or -O-C 1 -C 3 haloalkyl; R 4 is H or -CH 3; moiety is R aa is H or -CH 3; R bb is H, -CH 3 or -CF 3; R cc is -CH 3, -CD 3 or -CH 2 CF 3; moiety is E is N or CH; F is O, S, NH or NCH 3; R a is H or -CH 3; R b is H, D, -OH, F, -C 1 -C 5 alkyl, -CH 2 OCH 3, -C 1 -C 5 haloalkyl, -NH 2, cyclopropyl, or -CH 2 OH; R c is H, D or -CH 3; R d is H, -CN, -CF 3, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, -O-C 1 -C 3 alkyl, -N(R 6)R 7, wherein R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3, -COCH 3, -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3, -COCH 3, -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R e is H, -CD 3, Br, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, or -C 1 -C 5 alkyl substituted with 1 to 3 R g groups, wherein R g is -NH 2, or F; R 10 is H orF; R 11 is H or F; R 10 is H orF; R 11 is H or F; R f is H, -CH 3 or R h is -CH 3, -NH 2 or R i is H, -CH 3, -CN, Br, R j is -NH 2 or R k is H, -CF 3, I, Cl, Br, -CN, -C 1 -C 6 alkyl, R 12 is H or -CH 3; R 13 is H, -CH 3, -CH 2 (CH 3) 2 OH, -(CH 2) 3 CN, or -(CH 2) 2 NH 2; R 14 is H or -CH 3; R 12 is H or -CH 3; R 13 is H, -CH 3, -CH 2 (CH 3) 2 OH, -(CH 2) 3 CN, or -(CH 2) 2 NH 2; R 14 is H or -CH 3; R l is H, -C 1 -C 4 alkyl, -CF 3, R m is H or -CH 3; R n is -NH 2; R o is H or -CH 3; R p is H or -CH 3; R q is H, -CN, F, Cl, -OCH 3, -CF 3, or -CH 3; and R s is -NH 2 or provided that when moiety is and each R 1, R 2, R 3 and R 4 is H, then moiety is