A polypeptide comprising an immunoglobulin chain variable domain which binds to TNF-alpha, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3) and four framework regions (FR1-FR4), wherein: (a) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 2 and the sequence of CDR3 comprises SEQ ID NO: 3; (b) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 63 and the sequence of CDR3 comprises SEQ ID NO: 70; (c) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 64 and the sequence of CDR3 comprises SEQ ID NO: 70; (d) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 65 and the sequence of CDR3 comprises SEQ ID NO: 70, (e) the sequence of CDR1 comprises SEQ ID NO: 59, the sequence of CDR2 comprises SEQ ID NO: 66 and the sequence of CDR3 comprises SEQ ID NO: 71; (f) the sequence of CDR1 comprises SEQ ID NO: 60, the sequence of CDR2 comprises SEQ ID NO: 67, and the sequence of CDR3 comprises SEQ ID NO: 70; (g) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 67 and the sequence of CDR3 comprises SEQ ID NO: 70; (h) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 68 and the sequence of CDR3 comprises SEQ ID NO: 72; (i) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 69 and the sequence of CDR3 comprises SEQ ID NO: 70; (j) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 62 and the sequence of CDR3 comprises SEQ ID NO: 70; (k) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 69 and the sequence of CDR3 comprises SEQ ID NO: 3; (l) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 2 and the sequence of CDR3 comprises SEQ ID NO: 70; (m) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 61 and the sequence of CDR3 comprises SEQ ID NO: 70 or (n) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 62 and the sequence of CDR3 comprises SEQ ID NO: 3 and wherein the polypeptide neutralizes human TNF-alpha cytotoxicity in the normal L929 assay with an EC50 of 0.7 nM or less. (a) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 2 and the sequence of CDR3 comprises SEQ ID NO: 3; (b) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 63 and the sequence of CDR3 comprises SEQ ID NO: 70; (c) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 64 and the sequence of CDR3 comprises SEQ ID NO: 70; (d) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 65 and the sequence of CDR3 comprises SEQ ID NO: 70, (e) the sequence of CDR1 comprises SEQ ID NO: 59, the sequence of CDR2 comprises SEQ ID NO: 66 and the sequence of CDR3 comprises SEQ ID NO: 71; (f) the sequence of CDR1 comprises SEQ ID NO: 60, the sequence of CDR2 comprises SEQ ID NO: 67, and the sequence of CDR3 comprises SEQ ID NO: 70; (g) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 67 and the sequence of CDR3 comprises SEQ ID NO: 70; (h) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 68 and the sequence of CDR3 comprises SEQ ID NO: 72; (i) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 69 and the sequence of CDR3 comprises SEQ ID NO: 70; (j) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 62 and the sequence of CDR3 comprises SEQ ID NO: 70; (k) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 69 and the sequence of CDR3 comprises SEQ ID NO: 3; (l) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 2 and the sequence of CDR3 comprises SEQ ID NO: 70; (m) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 61 and the sequence of CDR3 comprises SEQ ID NO: 70 or (n) the sequence of CDR1 comprises SEQ ID NO: 1, the sequence of CDR2 comprises SEQ ID NO: 62 and the sequence of CDR3 comprises SEQ ID NO: 3