An offloading and reduced-pressure treatment system comprising: an offloading and reduced-pressure treatment device, wherein the offloading and reduced pressure treatment device comprises: a plantar member formed from an offloading manifold material; wherein the offloading manifold material comprises: a support layer having a first, tissue-facing surface and a second surface, a pressure-transmitting layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the pressure-transmitting member coupled to the second surface of the support layer, and a first barrier layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the first barrier layer coupled to the second surface of the pressure-transmitting layer; a reduced-pressure interface fluidly coupled to the pressure-transmitting layer of the plantar member; a reduced-pressure source; and a reduced-pressure delivery conduit fluidly coupled to the reduced-pressure source and to the reduced-pressure interface. an offloading and reduced-pressure treatment device, wherein the offloading and reduced pressure treatment device comprises: a plantar member formed from an offloading manifold material; wherein the offloading manifold material comprises: a support layer having a first, tissue-facing surface and a second surface, a pressure-transmitting layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the pressure-transmitting member coupled to the second surface of the support layer, and a first barrier layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the first barrier layer coupled to the second surface of the pressure-transmitting layer; a reduced-pressure interface fluidly coupled to the pressure-transmitting layer of the plantar member; a reduced-pressure source; and a reduced-pressure delivery conduit fluidly coupled to the reduced-pressure source and to the reduced-pressure interface. a plantar member formed from an offloading manifold material; wherein the offloading manifold material comprises: a support layer having a first, tissue-facing surface and a second surface, a pressure-transmitting layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the pressure-transmitting member coupled to the second surface of the support layer, and a first barrier layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the first barrier layer coupled to the second surface of the pressure-transmitting layer; a support layer having a first, tissue-facing surface and a second surface, a pressure-transmitting layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the pressure-transmitting member coupled to the second surface of the support layer, and a first barrier layer having a first, tissue-facing surface and a second surface, the first, tissue-facing surface of the first barrier layer coupled to the second surface of the pressure-transmitting layer; a reduced-pressure interface fluidly coupled to the pressure-transmitting layer of the plantar member; a reduced-pressure source; and a reduced-pressure delivery conduit fluidly coupled to the reduced-pressure source and to the reduced-pressure interface.