mhurhangee/ep-ind-claims huggingface dataset:
A method of identifying a candidate inhibitor substance that inhibits hepsin activation of pro-macrophage-stimulating protein (pro-MSP), said method comprising: (a) contacting a candidate substance with a first sample comprising hepsin and a pro-MSP substrate, and (b) comparing amount of pro-MSP substrate activation in the sample with amount of pro-MSP substrate activation in a reference sample comprising similar amounts of hepsin and pro-MSP substrate as the first sample but that has not been contacted with said candidate substance, whereby a decrease in amount of pro-MSP substrate activation in the first sample compared to the reference sample indicates that the candidate substance is capable of inhibiting hepsin activation of single chain MSP (pro-MSP).
Method for producing a jointless shower tray made from waterproof natural or artificial stone or ceramics material using abrasive machining methods, the drainage surface (4, 11, 19, 23, 25, 30) which collects the water and guides it to the drainage opening (6, 14, 16, 27, 31, 32) of the shower tray (1, 10, 15, 18, 21, 24, 28, 29) being formed as a concave or convex curved surface and being machined from a block of material having at least two plane-parallel surfaces, characterised in that the drainage surface (4, 11, 19, 23, 25, 30) is produced in one continuous operation by means of a program-controlled three-dimensional machining method.
A last extension for a last for an article of footwear, the last extension comprising a body, the body comprising: an upper surface and a lower surface; a first surface and a second surface, the first surface and the second surface extending between the upper surface and the lower surface; and a dimensional pattern on at least the first surface, the pattern comprising: a groove having a width and depth; and a circle off the groove; the last extension further comprising a mounting mechanism for mating the last extension in a fixed position to the last with the lower surface proximal to the last relative to the upper surface, wherein the mounting mechanism comprises at least two protrusions (250, 260) situated along the lower surface of the body and permanently attached to the last extension, wherein the protrusions (250, 260) are joinable to corresponding cavities on the last. an upper surface and a lower surface; a first surface and a second surface, the first surface and the second surface extending between the upper surface and the lower surface; and a dimensional pattern on at least the first surface, the pattern comprising: a groove having a width and depth; and a circle off the groove; a groove having a width and depth; and a circle off the groove; the last extension further comprising a mounting mechanism for mating the last extension in a fixed position to the last with the lower surface proximal to the last relative to the upper surface, wherein the mounting mechanism comprises at least two protrusions (250, 260) situated along the lower surface of the body and permanently attached to the last extension, wherein the protrusions (250, 260) are joinable to corresponding cavities on the last.
A method for preventing hardener compounds to be formed from hardener precursors in an aerosol formulation suitable for use in aerosol can for making a paint or adhesive, wherein said aerosol formulation is prepared by adding into said can following compounds: - paint forming chemicals comprising an epoxy resin and an epoxy hardener precursor; - a weak acid and a possible solvent; and mixing said paint forming chemicals; weak acid and a possible solvent to obtain a mixture before or after adding said compounds into said can, characterized thereof, that - the weak acid (XCOOH) is added only a catalytic amount from 0.1 to 10 % by weight (w/w) of the aerosol formulation, preferable 0.1 to 5 % by weight (w/w) of the aerosol formulation, wherein said weak acid is selected from the group in which weak acid have the dissociation constant pKa value in the range from 1.2 to 5.2, to shift, in the presence of (free) water and ketone, the reaction balance between epoxy hardener precursor and epoxy hardener amines to favour the formation of epoxy hardener precursors according to general reaction: so that formation of epoxy hardener amines is prevented from said epoxy hardener precursors; wherein said epoxy hardener precursors, are selected from the group composing of an imine, an enamine, a Mannich base, an aldimine and mixtures thereof. - paint forming chemicals comprising an epoxy resin and an epoxy hardener precursor; - a weak acid and a possible solvent; and - the weak acid (XCOOH) is added only a catalytic amount from 0.1 to 10 % by weight (w/w) of the aerosol formulation, preferable 0.1 to 5 % by weight (w/w) of the aerosol formulation, wherein said weak acid is selected from the group in which weak acid have the dissociation constant pKa value in the range from 1.2 to 5.2, to shift, in the presence of (free) water and ketone, the reaction balance between epoxy hardener precursor and epoxy hardener amines to favour the formation of epoxy hardener precursors according to general reaction: so that formation of epoxy hardener amines is prevented from said epoxy hardener precursors; wherein said epoxy hardener precursors, are selected from the group composing of an imine, an enamine, a Mannich base, an aldimine and mixtures thereof.
Method of manufacturing an oral prolonged release pharmaceutical composition comprising at least the steps of: a) producing granules comprising at least one prolonged release material, wherein the granules do not comprise a pharmaceutically active agent; b) selecting granules of step a) of substantially uniform size; c) blending said granules of step b) with at least two pharmaceutically active agent, wherein the first pharmaceutically active agent is an opioid agonist and the second pharmaceutically active agent is an opioid antagonist, and wherein the at least two pharmaceutically active agents are provided as such that they are not comprised within granules; d) compressing said blended granules of step c) to obtain an oral prolonged release pharmaceutical composition in the form of a tablet. a) producing granules comprising at least one prolonged release material, wherein the granules do not comprise a pharmaceutically active agent; b) selecting granules of step a) of substantially uniform size; c) blending said granules of step b) with at least two pharmaceutically active agent, wherein the first pharmaceutically active agent is an opioid agonist and the second pharmaceutically active agent is an opioid antagonist, and wherein the at least two pharmaceutically active agents are provided as such that they are not comprised within granules; d) compressing said blended granules of step c) to obtain an oral prolonged release pharmaceutical composition in the form of a tablet.
An item of furniture, in particular a cabinet, comprising at least two hingedly interconnected door leaves (1, 2) which can be situated at least in a folded position and in a spread-apart position, wherein the item of furniture comprises an arrangement for spreading apart the door leaves (1, 2) from the folded position into the spread-apart position, wherein the arrangement comprises an energy accumulator and a spreading element which can impinged by the energy accumulator, and a control contour by means of which the movement of the spreading element can be controlled, wherein there is provided in the item of furniture a, preferably fully, inserted position for the at least two door leaves (1, 2) in the folded position, wherein there is provided an ejection device for ejecting the at least two door leaves (1, 2) in the folded position from the inserted position in the item of furniture into an open position beyond the item of furniture, wherein the at least two door leaves (1, 2) can be ejected by means of the ejection device in their folded position from the inserted position in the item of furniture into the open position beyond the item of furniture and can then be transferred by means of the spreading element which can be impinged by the energy accumulator from the folded position into the spread-apart position.
A protein composition suitable for an infant milk formula, the composition comprising casein, whey protein and at least one high isoelectric protein from a non-dairy source, said high isoelectric protein having an isoelectric point of between 6.0 and 11, wherein the weight ratio of the sum of casein and whey protein to the high-isoelectric protein in the composition is between 95:5 and 75:25.
An electronic device, comprising a memory and a processor connected with the memory, wherein the memory stores at least one computer readable instruction, and the at least one computer readable instruction is executed by the processor to implement the following steps: S1, after current voice data of a target user to be subjected to identity verification are received, carrying out framing processing on the current voice data according to preset framing parameters to obtain multiple voice frames; S2, extracting preset types of acoustic features in all the voice frames by using a predetermined filter, and generating multiple observed feature units corresponding to the current voice data according to the extracted acoustic features; S3, pairwise coupling each of the generated observed feature units with pre-stored observed feature units respectively to obtain multiple groups of coupled observed feature units; S4, inputting the multiple groups of coupled observed feature units into a preset type of identity verification model generated by pre-training, and obtaining an output identity verification result to carry out the identity verification on the target user. S1, after current voice data of a target user to be subjected to identity verification are received, carrying out framing processing on the current voice data according to preset framing parameters to obtain multiple voice frames; S2, extracting preset types of acoustic features in all the voice frames by using a predetermined filter, and generating multiple observed feature units corresponding to the current voice data according to the extracted acoustic features; S3, pairwise coupling each of the generated observed feature units with pre-stored observed feature units respectively to obtain multiple groups of coupled observed feature units; S4, inputting the multiple groups of coupled observed feature units into a preset type of identity verification model generated by pre-training, and obtaining an output identity verification result to carry out the identity verification on the target user.
A system for persistently increasing the overall diameter and lumen diameter of a peripheral vein to create an arteriovenous fistula or an arteriovenous graft using at least a portion of the peripheral vein having the persistently-increased overall diameter, the system comprising: a rotary blood pump comprising an inlet and an outlet; a first conduit fluidly coupled to the pump and configured to be coupled to a donating vessel; a second conduit fluidly coupled to the pump and wherein at least a portion of the second conduit is configured for making a surgical anastomosis with the peripheral vein; and a control unit in communication with the pump, wherein the control unit comprises at least one sensor that measures pressure of the blood in at least one of the first conduit, the inlet, the outlet, and the second conduit; wherein the inlet is in fluid communication with the first conduit, the first conduit extending away from the inlet; and the outlet is in fluid communication with the second conduit, the second conduit extending away from the outlet, wherein the first conduit is configured for fluid communication with the donating vessel and the second conduit is configured for fluid communication with the peripheral vein; wherein, the control unit is configured to regulate the pump to pump blood such that the mean pulse pressure in the peripheral vein is less than 20 mmHg and the control unit is further configured to regulate the pump to pump blood such that the wall shear stress in the peripheral vein is between 0.76 Pa and 23 Pa; wherein the system is configured to operate continuously for a period of time between 7 days and 84 days. a rotary blood pump comprising an inlet and an outlet; a first conduit fluidly coupled to the pump and configured to be coupled to a donating vessel; a second conduit fluidly coupled to the pump and wherein at least a portion of the second conduit is configured for making a surgical anastomosis with the peripheral vein; and a control unit in communication with the pump, wherein the control unit comprises at least one sensor that measures pressure of the blood in at least one of the first conduit, the inlet, the outlet, and the second conduit; wherein the inlet is in fluid communication with the first conduit, the first conduit extending away from the inlet; and the outlet is in fluid communication with the second conduit, the second conduit extending away from the outlet, wherein the first conduit is configured for fluid communication with the donating vessel and the second conduit is configured for fluid communication with the peripheral vein; wherein, the control unit is configured to regulate the pump to pump blood such that the mean pulse pressure in the peripheral vein is less than 20 mmHg and the control unit is further configured to regulate the pump to pump blood such that the wall shear stress in the peripheral vein is between 0.76 Pa and 23 Pa; wherein the system is configured to operate continuously for a period of time between 7 days and 84 days.
Composition comprising A) 64.0-99.94 wt% of aromatic polycarbonate and B) 0.05 to 3.0 wt% of at least one polyglycidyl ether compound of the formula in which R 4 is a C 1 - to C 8 -alkyl group or an aryl group, where the alkyl group is branched or unbranched, and R 11 to R 13 are the same or different and are H, C 1 - to C 8 -alkyl radicals or aryl radicals, where the alkyl radicals are branched or unbranched. A) 64.0-99.94 wt% of aromatic polycarbonate and B) 0.05 to 3.0 wt% of at least one polyglycidyl ether compound of the formula in which R 4 is a C 1 - to C 8 -alkyl group or an aryl group, where the alkyl group is branched or unbranched, and R 11 to R 13 are the same or different and are H, C 1 - to C 8 -alkyl radicals or aryl radicals, where the alkyl radicals are branched or unbranched.
A regenerative energy absorption device for damping forces, particularly tensile, impact and/or torsional forces, occurring during operation of a track-guided vehicle, wherein the energy absorption device comprises at least one spring device having an elastomer body which is designed so as to at least in part deform elastically upon the introduction of forces into the energy absorption device, characterized in that at least part of the elastomer body is formed from an electrically conductive material, the specific electrical resistance of which varies under tensile and/or compressive load, and wherein the energy absorption device is allocated a resistance sensor device for detecting an electrical conductivity or electrical resistance of the electrically conductive material.
A wiring board comprising a via conductor (3, 36 to 47), having dispersed therein an inorganic matter (7, 8) being ceramic particles, or glass, or SiO 2, Al 2 O 3 or TiO 2, wherein in a cross section in a thickness direction of the wiring board, a total area of the inorganic matter (7, 8) having a particle size of 2 μm or more is 10% or less of the sectional area of the via conductor (3, 36 to 47), characterized by a part of the via conductor (3, 36 to 47) being exposed on a surface of the wiring board, wherein the part of the via conductor exposed on the surface of the wiring board is plated.
Mechanical connection for panels on their edge sides (5, 10) which are to be connected to one another, wherein adjacent first and second panels (1, 2) can be locked in horizontal and vertical direction by means of a substantially vertical joining motion, wherein for the vertical locking a locking edge is arranged on the first panel and a locking element which can be displaced with respect to the panels (1, 2) is arranged on the second panel, wherein the locking edge is located below a supporting strip which is formed as a projection on an edge side of the first panel and wherein the second panel rests in the locking position on the supporting strip between the top side and a locking strip of the first panel, wherein the locking strip protrudes furthest with respect to the edge side of the first panel and for horizontal locking grips below the second panel which is to be laid subsequently, wherein for horizontal locking, when lowering the second panel, a domed bead of the second panel comes into engagement with a domed channel, open upwardly, of the locking strip and a domed channel of the second panel comes into engagement with a domed bead of the locking strip, wherein the locking element can be displaced by means of a pivoting movement behind the locking edge, wherein the locking element has a locking projection for displacing behind the locking edge, characterised in that the locking element has an arcuate guiding arm which is guided in a guiding groove of the second panel and is configured to be drawn partially out of the guiding groove with a turning or pivoting movement of the locking element, in that a leg of the locking element projecting out of the guiding groove comes into contact with the first panel (1, 2) in a region below the locking edge during laying. wherein the locking element can be displaced by means of a pivoting movement behind the locking edge, wherein the locking element has a locking projection for displacing behind the locking edge, characterised in that the locking element has an arcuate guiding arm which is guided in a guiding groove of the second panel and is configured to be drawn partially out of the guiding groove with a turning or pivoting movement of the locking element, in that a leg of the locking element projecting out of the guiding groove comes into contact with the first panel (1, 2) in a region below the locking edge during laying.
A bush assembly comprising a component having a bore, a bush fitted in the bore and having a flange that extends radially outwardly over a surface of the component surrounding the bore, and a seal assembly for sealing the interface between the flange and the surface of the component, characterised in that the seal assembly includes a seal member and a layer of sealant between the seal member and the interface between the flange and the surface of the component.
A kit for making an adhesive comprising: a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer having one or more aldehyde groups; and a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups, wherein less than 75 % of the surface groups comprise at least one primary or secondary amine. a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer having one or more aldehyde groups; and a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups, wherein less than 75 % of the surface groups comprise at least one primary or secondary amine.
A panel of bacteriophage, wherein the panel comprises any one or more bacteriophage selected from the group consisting of:- NCTC 12081404, NCTC 12081405, NCTC 12081406, NCTC 12081407, NCTC 12081408, NCTC 12081409 and NCTC 12081410.
A method to produce a photocatalyst by precipitating titanium dioxide on a sol of manganese dioxide comprising (i) obtaining the hydrated manganese dioxide sol, (ii) providing a mixture including a) the hydrated manganese dioxide sol, b) titanium solution and c) NH 3 solution, and (iii) processing the mixture to obtain powder including manganese dioxide and titanium dioxide.
A graft preparation system (200, 600) comprising: a spine (206, 302, 802) having first and second ends; a plurality of windings (210, 324, 406, 804, 902, 1002, 1202) formed from a first suture (212, 306, 805, 1003) and spaced longitudinally along the spine, each winding being coupled to the spine by passing the first suture through attachment elements longitudinally spaced along the spine; and a second, anchor suture (208, 306) configured to position the spine and the plurality of windings coupled thereto around a graft, the anchor suture being coupled to the spine by passing through at least one of the attachment elements adjacent to the first end of the spine. a spine (206, 302, 802) having first and second ends; a plurality of windings (210, 324, 406, 804, 902, 1002, 1202) formed from a first suture (212, 306, 805, 1003) and spaced longitudinally along the spine, each winding being coupled to the spine by passing the first suture through attachment elements longitudinally spaced along the spine; and a second, anchor suture (208, 306) configured to position the spine and the plurality of windings coupled thereto around a graft, the anchor suture being coupled to the spine by passing through at least one of the attachment elements adjacent to the first end of the spine.
A turbomachine compressor, such as a highpressure compressor, including air bleed means comprising a duct having a suction end opening out into an outer casing of the compressor level with a rotor wheel and a stator stage of the compressor, characterized in that a screen sheet of annular shape is mounted radially inside the casing facing a portion of the suction end of the duct so as to make the bleeding of air uniform over 360° around the axis of the compressor.
A method for producing hypromellose acetate succinate, comprising: an esterification step of reacting hypromellose with esterification agents in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate; a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension; a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate; and a drying step of drying the liquid-removed hypromellose acetate succinate; wherein in the liquid removal step, an average particle size, determined by a sieve analysis, is reduced by 10 to 90% with the centrifugal decanter; and the liquid-removed hypromellose acetate succinate has an average particle size, determined by a sieve analysis, of 70 to 400 μm. an esterification step of reacting hypromellose with esterification agents in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate; a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension; a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate; and a drying step of drying the liquid-removed hypromellose acetate succinate;