A compound of Formula III, wherein X and X' are each independently CR 8 or N; Y is independently N or CR 8'; provided that at least one of X, X' or Y is not N; R 1 is C 6 -C 6 alkyl or C 3 -C 6 cycloalkyl, wherein said alkyl or cycloalkyl is optionally substituted with deuterium, halogen, OH, cyano, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy or C 1 -C 6 alkylthiolyl; R 3a and R 3b are each independently hydrogen or C 1 -C 3 alkyl; R 4 for each occurrence (one, two, three, four or five) is independently and optionally halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, -OR 5, -(CR 3a R 3b) n -(3- to 6- membered cycloalkyl), -(CR 3a R 3b) n -(4- to 6- membered heterocycloalkyl) wherein said alkyl, cycloalkyl or heterocycloalkyl is each optionally and independently substituted with one to five deuterium, halogen, OH, CN, -C (CH 2) t CN or -C 1 -C 6 alkoxy; -NR 11a R 11b; two R 4 taken together with the respective carbons to which each are bonded form a cyclopropyl, cyclobutyl or cyclopentyl, wherein said cyclopropyl, cyclobutyl or cyclopentyl is optionally substituted with one to three F, Cl, OH, methyl, ethyl, propyl, C 1 -C 3 fluoroalkyl, C 1 -C 3 difluoroalkyl, C 1 -C 3 trifluoroalkyl, C 1 -C 3 hydroxyalkyl, methoxy or ethoxy; R 5 is hydrogen or C 1 -C 6 alkyl, wherein said alkyl is optionally substituted with fluoro; R 8 is independently hydrogen, halogen, cyano, -NR 11a R 11b, C 1 -C 6 alkyl, 5- to 6-membered heteroaryl or aryl, wherein said alkyl or heteroaryl or aryl is optionally substituted with one, two or three halogen, -NR 11a R 11b, C 1 -C 3 alkyl or oxo; R 8' is hydrogen, deuterium, halogen or cyano; R 11a and R 11b are each independently hydrogen or C 1 -C 6 alkyl, wherein said alkyl is optionally substituted with OH; n is independently 0 or 1; and t is 1, 2 or 3; or a pharmaceutically acceptable salt of said compound or a tautomer of said compound or said salt. X and X' are each independently CR 8 or N; Y is independently N or CR 8'; provided that at least one of X, X' or Y is not N; R 1 is C 6 -C 6 alkyl or C 3 -C 6 cycloalkyl, wherein said alkyl or cycloalkyl is optionally substituted with deuterium, halogen, OH, cyano, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy or C 1 -C 6 alkylthiolyl; R 3a and R 3b are each independently hydrogen or C 1 -C 3 alkyl; R 4 for each occurrence (one, two, three, four or five) is independently and optionally halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, -OR 5, -(CR 3a R 3b) n -(3- to 6- membered cycloalkyl), -(CR 3a R 3b) n -(4- to 6- membered heterocycloalkyl) wherein said alkyl, cycloalkyl or heterocycloalkyl is each optionally and independently substituted with one to five deuterium, halogen, OH, CN, -C (CH 2) t CN or -C 1 -C 6 alkoxy; -NR 11a R 11b; two R 4 taken together with the respective carbons to which each are bonded form a cyclopropyl, cyclobutyl or cyclopentyl, wherein said cyclopropyl, cyclobutyl or cyclopentyl is optionally substituted with one to three F, Cl, OH, methyl, ethyl, propyl, C 1 -C 3 fluoroalkyl, C 1 -C 3 difluoroalkyl, C 1 -C 3 trifluoroalkyl, C 1 -C 3 hydroxyalkyl, methoxy or ethoxy; R 5 is hydrogen or C 1 -C 6 alkyl, wherein said alkyl is optionally substituted with fluoro; R 8 is independently hydrogen, halogen, cyano, -NR 11a R 11b, C 1 -C 6 alkyl, 5- to 6-membered heteroaryl or aryl, wherein said alkyl or heteroaryl or aryl is optionally substituted with one, two or three halogen, -NR 11a R 11b, C 1 -C 3 alkyl or oxo; R 8' is hydrogen, deuterium, halogen or cyano; R 11a and R 11b are each independently hydrogen or C 1 -C 6 alkyl, wherein said alkyl is optionally substituted with OH; n is independently 0 or 1; and t is 1, 2 or 3;