mhurhangee/ep-ind-claims huggingface dataset:
An oligonucleotide comprising: at least one nucleotide having both (a) a 2' modification; and (b) an amino carbonyl base modification at the C-5 position of a pyrimidine base, wherein the oligonucleotide hybridizes to a human microRNA with high affinity and is from 6 to 22 nucleotides in length and contains one or more phosphorothioate linkages; and wherein the 2' modification is 2'-OMe and wherein the amino carbonyl base modification has the following structure: wherein R is at least one member selected from the group consisting of: at least one nucleotide having both (a) a 2' modification; and (b) an amino carbonyl base modification at the C-5 position of a pyrimidine base, wherein the oligonucleotide hybridizes to a human microRNA with high affinity and is from 6 to 22 nucleotides in length and contains one or more phosphorothioate linkages; and wherein the 2' modification is 2'-OMe and wherein the amino carbonyl base modification has the following structure: wherein R is at least one member selected from the group consisting of: (a) a 2' modification; and (b) an amino carbonyl base modification at the C-5 position of a pyrimidine base,
A method for subscriber unit operation in a wireless communications system, the wireless communications system having a base station, the method comprising: computing an estimate of a communications channel between the subscriber unit and the base station; quantizing the estimate with a first codebook, thereby producing a first quantized estimate; quantizing an ( n -1)-th quantized estimate with an n -th codebook, thereby producing an n- th quantized estimate, where n is an integer value ranging from 2 to R and n initially being equal to 2, R is a total number of quantizations of the estimate, wherein the n -th codebook is a localized codebook at a radius γ 2m, with a scaling factor γ being a parameter of a progressive refinement algorithm, and the value of m is chosen based on a mobility estimation; incrementing n; repeating the quantizing an ( n -1)-th quantized estimate until n > R; and transmitting information based on the R quantized estimates to the base station. computing an estimate of a communications channel between the subscriber unit and the base station; quantizing the estimate with a first codebook, thereby producing a first quantized estimate; quantizing an ( n -1)-th quantized estimate with an n -th codebook, thereby producing an n- th quantized estimate, where n is an integer value ranging from 2 to R and n initially being equal to 2, R is a total number of quantizations of the estimate, wherein the n -th codebook is a localized codebook at a radius γ 2m, with a scaling factor γ being a parameter of a progressive refinement algorithm, and the value of m is chosen based on a mobility estimation; incrementing n; repeating the quantizing an ( n -1)-th quantized estimate until n > R; and transmitting information based on the R quantized estimates to the base station.
Fuel pump of a fuel injection equipment of an internal combustion engine, the pump having a housing provided with an axial bore defining a compression chamber, the pump being further provided with a cylindrical piston slidably arranged in the bore, the piston extending from a top extremity that is inside the bore, defining a high pressure extremity, to a lower extremity, defining a low pressure extremity, the piston being able to reciprocally slide between a lower position where fuel at low pressure enters the compression chamber via an inlet and, an top position where fuel present in the compression chamber is pressurized before being expelled via an outlet, wherein the piston is provided with a dilation means (20, 22, 24) arranged on its high pressure extremity, said means (20, 22, 24) enabling the piston to expand radially when fuel in the compression chamber is pressurized and wherein, the dilation means is a recess provided on the top face of the piston, said recess being surrounded by a peripheral wall integral to the piston and wherein, the dilation means further comprises a pressure drop feature (28, 30) enabling pressurized fuel to drop in pressure and to flow toward a low pressure circuit, the location of said feature (28, 30) limiting the portion of the piston that expands under fuel pressure, characterized in that the pressure drop feature (28, 30) comprises a groove ring arranged on the outer cylindrical face of the peripheral wall and a fuel path extending from said groove ring toward the low pressure circuit.
A device for coupling an HF signal along a signal path, which extends between a first and a second coaxial HF connection structure, wherein the two coaxial HF connection structures (1, 2) each comprise an internal conductor (3, 4) electrically connected to each other via a line structure with the line structure being capacitively coupled to an electrically conducting coupling structure, via which the HF signal can be coupled along the signal path, wherein the line structure consistently connects the two coaxial HF connection structures (1, 2) to each other, a bore or opening oriented essentially transversely to the longitudinal extension of the line structure is drilled along the line structure, through which a first portion of the coupling structure protrudes, the first portion of the coupling structure and the line structure are spaced apart from each other by means of an insulator, the HF signal can be capacitively coupled between the first portion of the coupling structure and the line structure, characterised in that the coupling capacity between the coupling structure and the line structure is constant.
Use of a multifunctional hydrocarbon oil composition as a metalworking oil composition, the multifunctional hydrocarbon oil comprising a hydrocarbon oil having a density at 15°C of 0.7 to 0.8 g/cm 3 and including a n-paraffin content of 10 to 90% by mass, an aromatic content of 0 to 3 % by volume, and a naphthene content of 0 to 20% by volume relative to the total hydrocarbon oil, 1 to 70 mass% relative to the total composition and an ester oil consisting of at least one selected from a synthetic ester of C1 to C24 monohydric or polyhydric alcohol and monobasic C2 to C24 fatty acid or C2 to C16 polybasic acid and a naturally-derived ester, 10-95 mass% relative to the total composition, the ester oil having a kinematic viscosity at 40°C of 1 to 300 mm 2 /s, wherein said hydrocarbon oil is a light oil/kerosene fraction produced by a production process having at least one process selected from a Fischer-Tropsch synthetic process, a hydrocracking process for a wax-containing component, and a hydrogenation refining process for a component obtained from these processes, wherein the distillation properties of the hydrocarbon oil based on JIS K2554 (Engler distillation) are; the initial boiling point is 160-180°C, the 10% distillation point is 160-214°C, the 50%-distillation point is 170-230°C, the 90%-distillation point is 190-250°C and the end point is 190-400°C.
A method of displaying a screen of an electronic device, the method comprising: detecting a user gesture for unlocking a sleep state of the electronic device; determining a screen display direction based on the detected user gesture during the sleep state; and displaying the screen based on the determined screen display direction. detecting a user gesture for unlocking a sleep state of the electronic device; determining a screen display direction based on the detected user gesture during the sleep state; and displaying the screen based on the determined screen display direction.
An intraocular lens system comprising: a haptic system comprising: (i) a center portion; (ii) a plurality of radially disposed haptics attached to the center portion and adapted to move independently in response to forces of at least one of a ciliary muscle and zonules of an eye when implanted; (iii) a first accommodation restraining arm disposed proximate each one of the haptics and extending along a side thereof, each first accommodation restraining arm attached to the center portion; (iv) a second accommodation restraining arm disposed proximate each one of the haptics and extending along a second side thereof, each second accommodation restraining arm attached to the center portion, wherein a base of each one of the haptics is disposed between the respective first and second accommodation restraining arms; wherein the first and second accommodation restraining arms are configured to restrain each one of the haptics in a disaccommodated configuration by trapping each one of the haptics on top of the respective first and second accommodation restraining arms; and an optic connected to the haptics of the haptic system. a haptic system comprising: (i) a center portion; (ii) a plurality of radially disposed haptics attached to the center portion and adapted to move independently in response to forces of at least one of a ciliary muscle and zonules of an eye when implanted; (iii) a first accommodation restraining arm disposed proximate each one of the haptics and extending along a side thereof, each first accommodation restraining arm attached to the center portion; (iv) a second accommodation restraining arm disposed proximate each one of the haptics and extending along a second side thereof, each second accommodation restraining arm attached to the center portion, wherein a base of each one of the haptics is disposed between the respective first and second accommodation restraining arms; wherein the first and second accommodation restraining arms are configured to restrain each one of the haptics in a disaccommodated configuration by trapping each one of the haptics on top of the respective first and second accommodation restraining arms; and (i) a center portion; (ii) a plurality of radially disposed haptics attached to the center portion and adapted to move independently in response to forces of at least one of a ciliary muscle and zonules of an eye when implanted; (iii) a first accommodation restraining arm disposed proximate each one of the haptics and extending along a side thereof, each first accommodation restraining arm attached to the center portion; (iv) a second accommodation restraining arm disposed proximate each one of the haptics and extending along a second side thereof, each second accommodation restraining arm attached to the center portion, wherein a base of each one of the haptics is disposed between the respective first and second accommodation restraining arms; an optic connected to the haptics of the haptic system.
A method for producing amino acid chelate compounds, characterized in that metal oxides and/or metal carbonates and/or metal sulfates and/or metal chlorides and/or metal hydroxides in solid form are activated mechanically and then the activated metal oxides and/or metal carbonates and/or metal hydroxides and/or metal sulfates and/or metal chlorides are brought together with amino acids in solid form and converted to amino acid chelate compounds in a solid-state reaction, in which the activation and/or conversion takes place with an eccentric vibrating grinding mill and/or in another vibrating grinding mill and/or with an agitator ball and/or in a drum mill and/or with a mixed reactor and/or the activation and/or conversion takes place through mechanical stress by strike and pressure in a fine crushing machine.
A femtosecond laser source comprising: - an injecting laser oscillator based on optical fiber doped with a given dopant, suitable for delivering, via an exit optical fiber, a first picosecond pulse, at a first wavelength λ 1; - a power amplifier based on amplifying optical fiber for producing, from the first pulse, a second pulse, at the first wavelength, with an energy that is amplified with respect to the first pulse, the amplifying optical fiber being doped with the same dopant as the optical fiber of the injecting oscillator, having a length smaller than or equal to the distance of the soliton compression point and larger than the distance from which the amplifying optical fiber operates in non-linear regime; and - a frequency-shifting fiber suitable for receiving the second pulse and generating by Raman self-shifting a fundamental soliton at a second wavelength λ 2 strictly longer than the first wavelength λ 1, said shifting fiber having a modal area larger than an modal area of the amplifying fiber. - an injecting laser oscillator based on optical fiber doped with a given dopant, suitable for delivering, via an exit optical fiber, a first picosecond pulse, at a first wavelength λ 1; - a power amplifier based on amplifying optical fiber for producing, from the first pulse, a second pulse, at the first wavelength, with an energy that is amplified with respect to the first pulse, the amplifying optical fiber being doped with the same dopant as the optical fiber of the injecting oscillator, having a length smaller than or equal to the distance of the soliton compression point and larger than the distance from which the amplifying optical fiber operates in non-linear regime; and - a frequency-shifting fiber suitable for receiving the second pulse and generating by Raman self-shifting a fundamental soliton at a second wavelength λ 2 strictly longer than the first wavelength λ 1, said shifting fiber having a modal area larger than an modal area of the amplifying fiber.
Method for the solid-liquid separation of compositions and suspensions, comprising a continuously operated filtration chamber and one or more intermittently operated pressure chambers, in which a) the composition or the suspension is continuously fed into the filtration chamber and treated there by means of hydrostatic pressure of up to 0.2 bar, wherein from 80 to 90 % of the volume fed in is removed as a filtrate and the separation of the liquid phase is not interrupted, b) subsequently the condensed remaining volume is drawn off by means of a screw extruder and conveyed, at a pressure of up to 5 bar, into one of the pressure chambers and further treated there, and c) concludingly the remaining filtrate is separated off by means of reducing the volume of the pressure chamber with a pressure of up to 50 bar, wherein the further treatment is carried out in cycles downstream of the hydrostatic filtration in the pressure chamber and composition or suspension is fed into the filtration chamber in a continuous and uninterrupted manner throughout the entire operating time and the liquid phase is separated off while the filter cake is discharged in cycles from the pressure chamber, a) the composition or the suspension is continuously fed into the filtration chamber and treated there by means of hydrostatic pressure of up to 0.2 bar, wherein from 80 to 90 % of the volume fed in is removed as a filtrate and the separation of the liquid phase is not interrupted, b) subsequently the condensed remaining volume is drawn off by means of a screw extruder and conveyed, at a pressure of up to 5 bar, into one of the pressure chambers and further treated there, and c) concludingly the remaining filtrate is separated off by means of reducing the volume of the pressure chamber with a pressure of up to 50 bar, wherein the further treatment is carried out in cycles downstream of the hydrostatic filtration in the pressure chamber and composition or suspension is fed into the filtration chamber in a continuous and uninterrupted manner throughout the entire operating time and the liquid phase is separated off while the filter cake is discharged in cycles from the pressure chamber,
A hollow microneedle array for rapid, high-volume, intradermal infusion with minimal pain, the hollow microneedle array comprising: an array of 10 to 30 hollow microneedles having a length of greater than 100um to less than 1mm.; the hollow microneedle array being adapted for pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min; and being characterized in that the microneedles are spaced an average of at least 2 mm apart from each other. an array of 10 to 30 hollow microneedles having a length of greater than 100um to less than 1mm.; the hollow microneedle array being adapted for pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min; and being characterized in that the microneedles are spaced an average of at least 2 mm apart from each other.
A method of forming a gypsum based product, the method comprising the steps of: calcining a mixture of water and gypsum under conditions of raised temperature and pressure within a vessel to produce an alpha-hemihydrate slurry therein, wherein the raised temperature comprises a temperature within the range 110°C to 170°C, and wherein the raised pressure comprises a pressure within the range 2 to 8 Bars; reducing the water content of the alpha-hemihydrate slurry to provide a separate water stream from the alpha-hemihydrate slurry; and subsequently passing the alpha-hemihydrate slurry from the vessel to a mixer for mixing with additional water to reduce the temperature of the alpha-hemihydrate slurry and to produce a settable slurry, which is arranged to set to form the gypsum based product, wherein the additional water has a temperature of 20-30°C. calcining a mixture of water and gypsum under conditions of raised temperature and pressure within a vessel to produce an alpha-hemihydrate slurry therein, wherein the raised temperature comprises a temperature within the range 110°C to 170°C, and wherein the raised pressure comprises a pressure within the range 2 to 8 Bars; reducing the water content of the alpha-hemihydrate slurry to provide a separate water stream from the alpha-hemihydrate slurry; and subsequently passing the alpha-hemihydrate slurry from the vessel to a mixer for mixing with additional water to reduce the temperature of the alpha-hemihydrate slurry and to produce a settable slurry, which is arranged to set to form the gypsum based product, wherein the additional water has a temperature of 20-30°C.
A storage container for a prosthetic heart valve, comprising: a container housing sized to receive a heart valve in an expanded configuration; and a crimping mechanism incorporated into the storage container and operable to engage a heart valve and convert a heart valve from its expanded configuration to its crimped configuration as it passes through an opening in the container. a container housing sized to receive a heart valve in an expanded configuration; and a crimping mechanism incorporated into the storage container and operable to engage a heart valve and convert a heart valve from its expanded configuration to its crimped configuration as it passes through an opening in the container.
A high-temperature gasification method for producing synthetic gas from biomass, in which the temperature of the outlet of the gasification furnace is controlled between 1200 and 1600°C, comprising the steps of: feeding raw material, performing carbonization, charcoal milling, and delivering charcoal powder to the gasification furnace for gasification, characterized in that said carbonization comprises directly reacting a combustion of externally offered combustible gas and oxygen in the carbonization furnace, the heat emitted from the reaction being directly provided to the necessary heat of biomass pyrolysis, and producing pyrolysis gas and charcoal from the carbonization furnace, wherein the process of said charcoal milling comprises reducing the pressure of charcoal to atmospheric pressure through a charcoal depressurized feeding device, and then delivering the charcoal to a milling mechanism for producing charcoal powder, and then delivering the charcoal powder to a pressurized feeding system of the charcoal powder by a carrier gas at atmospheric pressure. feeding raw material, performing carbonization, charcoal milling, and delivering charcoal powder to the gasification furnace for gasification, characterized in that said carbonization comprises directly reacting a combustion of externally offered combustible gas and oxygen in the carbonization furnace, the heat emitted from the reaction being directly provided to the necessary heat of biomass pyrolysis, and producing pyrolysis gas and charcoal from the carbonization furnace,
Household appliance for treating an item to be treated, wherein the household appliance has a controller for carrying out all necessary treatment steps for achieving an intended treatment success in relation to the item to be treated and the controller is configured for autonomously carrying out the necessary treatment steps in relation to the identified item to be treated, wherein the controller comprises an input controller part, a base controller part and a computer-like expansion controller part (7; 17; 17'), wherein when the item to be treated is introduced into the household appliance, information about the item to be treated can be read into the controller of the household appliance via an input controller part, characterised in that the input controller part (5; 5') comprises a camera (14; 14') and the computer-like expansion controller part is realised by a server (17; 17') that can be coupled via the Internet and is also configured for identifying the item to be treated in terms of type and status via the input controller part on the basis of a mapping of the item to be treated which can be achieved by the camera (14; 14').
A battery casing for accommodating one or several interconnected battery modules, preferably of a vehicle, wherein the battery casing is formed as a high-strength and rigid structural element and the wall elements of the battery casing are each formed with a double wall, i.e. in sandwich design, with an inner wall and an outer wall (4, 2) spaced therefrom, and said intermediate space between said inner and outer wall (4, 2) is respectively filled with a porous and simultaneously crash-resistant support material and is subsequently evacuated, and in addition respective cooling elements are integrated in said intermediate space between the inner and outer wall (4, 2), wherein the battery casing is reversibly fully encapsulated, i.e. it is opened on one side in case of maintenance and it can subsequently be closed and evacuated again, wherein the opening and closing of a wall element of the battery casing can be realised via two elastomer-sealed flanges or blind flanges which are arranged one behind the other, one each for the inner wall and one for the outer wall (4 and 2), wherein the renewed evacuation of the battery casing can be carried out via a vacuum port welded into the outer wall in conjunction with a suitable transfer port system, or the inner and outer wall (4 and 2) of the battery casing are connected to each other via beadings, wherein the beads are formed in such a way that said connecting region can be separated and closed again several times.
An electrical installation device for installation technology which can be arranged in a fixed position and which comprises a housing comprising a lower part open at one side and an upper part for the sealed closure of an inner space, wherein the lower part comprises a rear wall and side walls and an electrical insert is arranged in the lower part, wherein the upper part comprises a functional element at the user side which represents a visible cover of the installation device, wherein a seal is arranged between the upper part and the lower part, and wherein the upper part is arranged in the lower part along its total periphery between the side walls, characterized in that the upper part and also the seal are inserted into the lower part in a flush manner.