Oral colonic release compositions able to enhance the proliferation and growth of both endogenous eubiotic bacteria, in particular probiotics, already present at the intestinal level, and of exogenous eubiotic bacteria present at the intestinal level upon their separate and extemporaneous administration, said compositions being in the form of tablets, powders or gastro-resistant capsules, consisting of: A) a combination of substances used as co-adjuvants for the growth of eubiotic bacteria, said combination consisting of: a) at least one essential amino acid, b) at least one protein hydrolysate of vegetable or animal origin, c) at least one trace element for use in the food or biochemical fields, d) at least one sugar selected from monosaccharides or di-saccharides, e) at least one mucoadhesive polysaccharide, capable of gelling in contact with the intestinal mucosa, B) conventional excipients wherein said tablets or powders are coated with, or the outer shell of said capsules comprises, an anionic copolymer, simultaneously containing repeating units of the following monomers: i) esters of acrylic and methacrylic acid with C1-C4, preferably C1-C2, alcohols and relative mixtures of said alcohols; ii) acrylic acid, methacrylic acid and relative mixtures, iii) wherein the ratio between the ester functional groups (carboxyalkyl) and the free carboxylic functional groups (COOH) in said polymer is between 8:1 and 12:1, and is able to release the components a) - e) at the level of the colon, said oral colonic release compositions being free from eubiotic, in particular probiotic bacteria and being able to enhance proliferation and growth of eubiotic, in particular probiotic bacteria at the intestinal level, wherein said eubiotic, in particular probiotic bacteria are of endogenous and optionally exogenous type, these latter being present at the intestinal level upon a separate administration with respect to said oral colonic release composition. A) a combination of substances used as co-adjuvants for the growth of eubiotic bacteria, said combination consisting of: a) at least one essential amino acid, b) at least one protein hydrolysate of vegetable or animal origin, c) at least one trace element for use in the food or biochemical fields, d) at least one sugar selected from monosaccharides or di-saccharides, e) at least one mucoadhesive polysaccharide, capable of gelling in contact with the intestinal mucosa, a) at least one essential amino acid, b) at least one protein hydrolysate of vegetable or animal origin, c) at least one trace element for use in the food or biochemical fields, d) at least one sugar selected from monosaccharides or di-saccharides, e) at least one mucoadhesive polysaccharide, capable of gelling in contact with the intestinal mucosa, B) conventional excipients wherein said tablets or powders are coated with, or the outer shell of said capsules comprises, an anionic copolymer, simultaneously containing repeating units of the following monomers: i) esters of acrylic and methacrylic acid with C1-C4, preferably C1-C2, alcohols and relative mixtures of said alcohols; ii) acrylic acid, methacrylic acid and relative mixtures, iii) wherein the ratio between the ester functional groups (carboxyalkyl) and the free carboxylic functional groups (COOH) in said polymer is between 8:1 and 12:1, and is able to release the components a) - e) at the level of the colon, said oral colonic release compositions being free from eubiotic, in particular probiotic bacteria and being able to enhance proliferation and growth of eubiotic, in particular probiotic bacteria at the intestinal level, wherein said eubiotic, in particular probiotic bacteria are of endogenous and optionally exogenous type, these latter being present at the intestinal level upon a separate administration with respect to said oral colonic release composition. wherein said tablets or powders are coated with, or the outer shell of said capsules comprises, an anionic copolymer, simultaneously containing repeating units of the following monomers: i) esters of acrylic and methacrylic acid with C1-C4, preferably C1-C2, alcohols and relative mixtures of said alcohols; ii) acrylic acid, methacrylic acid and relative mixtures, iii) wherein the ratio between the ester functional groups (carboxyalkyl) and the free carboxylic functional groups (COOH) in said polymer is between 8:1 and 12:1, and is able to release the components a) - e) at the level of the colon, i) esters of acrylic and methacrylic acid with C1-C4, preferably C1-C2, alcohols and relative mixtures of said alcohols; ii) acrylic acid, methacrylic acid and relative mixtures, iii) wherein the ratio between the ester functional groups (carboxyalkyl) and the free carboxylic functional groups (COOH) in said polymer is between 8:1 and 12:1, and is able to release the components a) - e) at the level of the colon, said oral colonic release compositions being free from eubiotic, in particular probiotic bacteria and being able to enhance proliferation and growth of eubiotic, in particular probiotic bacteria at the intestinal level, wherein said eubiotic, in particular probiotic bacteria are of endogenous and optionally exogenous type, these latter being present at the intestinal level upon a separate administration with respect to said oral colonic release composition.