mhurhangee/ep-ind-claims huggingface dataset:
A method for predicting the efficacy of ipilimumab for enhancing anti-tumour immunity in a patient, the method comprising the steps of: measuring pre-treatment levels of peripheral blood monocytes that are CD14 + and HLA-DR low (PBM14 + HLA-DR low) contained in a blood sample previously taken from the patient, comparing the measured pre-treatment levels in the blood sample to a discrimination threshold determined for a population of comparable patients, said discrimination threshold being selected to segregate the population into a sub-population of patients that tend to show improved overall survival over a period of up to 2 years from ipilimumab treatment and a sub-population of patients that do not tend to show improved overall survival over a period of up to 2 years from ipilimumab treatment with a p value (statistical probability) of at most 0.10, and determining that a measured level in the blood sample of PBM14 + HLA-DR low that is below the discrimination threshold indicates a likelihood of the efficacy of the therapeutic for enhancing said anti-tumour immunity in the patient. measuring pre-treatment levels of peripheral blood monocytes that are CD14 + and HLA-DR low (PBM14 + HLA-DR low) contained in a blood sample previously taken from the patient, comparing the measured pre-treatment levels in the blood sample to a discrimination threshold determined for a population of comparable patients, said discrimination threshold being selected to segregate the population into a sub-population of patients that tend to show improved overall survival over a period of up to 2 years from ipilimumab treatment and a sub-population of patients that do not tend to show improved overall survival over a period of up to 2 years from ipilimumab treatment with a p value (statistical probability) of at most 0.10, and determining that a measured level in the blood sample of PBM14 + HLA-DR low that is below the discrimination threshold indicates a likelihood of the efficacy of the therapeutic for enhancing said anti-tumour immunity in the patient.
Process for the production of electronic structures having an insulating or semiconducting or conductive zinc oxide layer or surface, characterised in that a. precursor solutions of an organometallic zinc complex which contains at least one ligand from the class of oximates, whereby the precursor is printable and is employed in the form of a printing ink or printing paste, and the zinc complex is free from alkali metals and alkaline-earth metals are applied to a substrate in a layered manner, optionally one or more times, corresponding to the electronic structure to be achieved, by dip coating, spin coating or ink-jet printing or flexographic/gravure printing, whereby the electronic structure is a printed field-effect transistor, b. calcining or drying of the applied precursor layer in air or oxygen atmosphere with formation of a zinc oxide layer or surface, c. optionally, finally sealing the applied electronic structure with an insulating layer, and providing it with contacts and completing it. a. precursor solutions of an organometallic zinc complex which contains at least one ligand from the class of oximates, whereby the precursor is printable and is employed in the form of a printing ink or printing paste, and the zinc complex is free from alkali metals and alkaline-earth metals are applied to a substrate in a layered manner, optionally one or more times, corresponding to the electronic structure to be achieved, by dip coating, spin coating or ink-jet printing or flexographic/gravure printing, whereby the electronic structure is a printed field-effect transistor, b. calcining or drying of the applied precursor layer in air or oxygen atmosphere with formation of a zinc oxide layer or surface, c. optionally, finally sealing the applied electronic structure with an insulating layer, and providing it with contacts and completing it.
Cleaning turbine having a cylindrical shape with an axis of rotation and provided with a concave base surface facing toward the work zone, with an upper surface, opposite the base surface, and a circumferential surface interposed between the base surface and the upper surface, said cleaning turbine being provided circumferentially with a plurality of slits angularly distanced from each other, facing upward and passing through said base surface and said upper surface, characterized in that said cleaning turbine is also provided with a plurality of lateral apertures each of which extends radially from said slits to said circumferential surface.
Brake actuating unit (1, 1') for a motor vehicle brake system of the brake-by-wire type, comprising • a housing, • a first hydraulic cylinder/piston arrangement having an actuating piston which is guided displaceably in the housing and delimits a hydraulic pressure chamber to which wheel brakes of the motor vehicle are connectable, the actuating piston being actuable by means of a push rod which transmits actuating forces, • an electrically controllable pressure supplying device which is in the form of a second hydraulic cylinder/piston arrangement, the piston of which can be displaced by an electric motor by means of a rotational-translational gear mechanism, and • a valve arrangement comprising a number of valves (41, 42, 43) for setting wheel-individual brake pressures and for disconnecting or connecting the wheel brakes from/to the first cylinder/piston arrangement or from/to the pressure supplying device, characterized in that the valve arrangement and the pressure supplying device are arranged at least partially inside the housing, the axis of the electric motor of the pressure supplying device being arranged substantially perpendicular to the longitudinal axis of the first cylinder/piston arrangement. • a housing, • a first hydraulic cylinder/piston arrangement having an actuating piston which is guided displaceably in the housing and delimits a hydraulic pressure chamber to which wheel brakes of the motor vehicle are connectable, the actuating piston being actuable by means of a push rod which transmits actuating forces, • an electrically controllable pressure supplying device which is in the form of a second hydraulic cylinder/piston arrangement, the piston of which can be displaced by an electric motor by means of a rotational-translational gear mechanism, and • a valve arrangement comprising a number of valves (41, 42, 43) for setting wheel-individual brake pressures and for disconnecting or connecting the wheel brakes from/to the first cylinder/piston arrangement or from/to the pressure supplying device,
Method of producing hexachlorodisilane (Si 2 Cl 6), wherein chlorinated polysilane of the formula SiCl x with x = 0.2 - 0.8 is oxidatively cleaved by chlorination.
An actuator for a parking lock, comprising at least the following components: - an axial drive means for transmitting an axial force; - an actuating element having an actuating axis, which is axially moveable from a normal position into a deflected position by means of the axial force of the axial drive means; - a stopper element; - a stopper component corresponding to the stopper element; and - a holding element which is moveable between a released position and a locking position, wherein, while the actuating element is in the deflected position, the stopper element and the stopper component are fixed relative to one another with the holding element in the locking position, wherein a solenoid having a coil and a piston that is axially moveable by means of a magnetic force generated by the coil is also provided, and wherein the holding element is fixedly connected to the axially moveable piston, characterised in that the magnetic flux generated by the coil is conducted through a return path, the return path comprises a radially inner return path and a radially outer return path, which surround the piston in a U-shape, an axial gap is present between the piston and the inner return path in at least one of the two positions of the holding element, and the magnetic flux is conducted through the two surfaces of the piston and the inner return path, which form the axial gap. - an axial drive means for transmitting an axial force; - an actuating element having an actuating axis, which is axially moveable from a normal position into a deflected position by means of the axial force of the axial drive means; - a stopper element; - a stopper component corresponding to the stopper element; and - a holding element which is moveable between a released position and a locking position, wherein, while the actuating element is in the deflected position, the stopper element and the stopper component are fixed relative to one another with the holding element in the locking position, wherein a solenoid having a coil and a piston that is axially moveable by means of a magnetic force generated by the coil is also provided, and wherein the holding element is fixedly connected to the axially moveable piston, characterised in that the magnetic flux generated by the coil is conducted through a return path, the return path comprises a radially inner return path and a radially outer return path, which surround the piston in a U-shape, an axial gap is present between the piston and the inner return path in at least one of the two positions of the holding element, and the magnetic flux is conducted through the two surfaces of the piston and the inner return path, which form the axial gap.
A laminate comprising: an active material layer that comprises a plurality of active material particles; and a separator that is layered on the active material layer, and comprises a first surface and a second surface opposed to the first surface, wherein the separator comprises particles comprising an inorganic compound having lithium ion conductivity at 25°C of 1 × 10 -10 S/cm or more, and a ratio (L/R max) of a thickness L to a radius R max satisfies 0 < L/R max ≤ 5, where the radius R max is a radius of the active material particle having a maximum particle size among the active material particles being in contact with the first surface of the separator, and the thickness L is distance from an interface between the active material particle having a maximum particle size and the first surface of the separator to the second surface of the separator, wherein an average particle size of the active material particles is within a range of 0.05 μm to 30 μm, wherein the radius R max is determined by observing the interface appearing on a cut surface of the laminate using a scanning electron microscope at a magnification of 5000, when the laminate has a square or polygonal shaped surface, the cut surface of the laminate is obtained by cutting the laminate along a diagonal line of the square or polygonal shaped surface such that the interface appearing on the cut surface has a length of 5 mm across a center of the diagonal line of the square or polygonal shaped surface, and when the laminate has a circular shaped or oval shaped surface, the cut surface of the laminate is obtained by cutting the laminate along a diameter of the circular shaped or oval shaped surface such that the interface appearing on the cut surface has a length of 5 mm across a central part of the circular shaped or oval shaped surface. an active material layer that comprises a plurality of active material particles; and a separator that is layered on the active material layer, and comprises a first surface and a second surface opposed to the first surface,
An optical test instrument comprising: an instrument casing, including measurement components therein; a cartridge receiving cavity extending within the instrument casing, the cartridge receiving cavity having: an inner end provided with a test instrument optical port; and an outer end provided with a cartridge receiving opening, the opening being located on the instrument casing; a connector cartridge sized and configured to fit in the cartridge receiving cavity, the connector cartridge having: a cartridge inner end which faces the test instrument optical port, and a cartridge outer end which receives an optic fiber from a device under test, the connector cartridge housing a fiber optic cable extending between the cartridge inner end and the cartridge outer end, the connector cartridge being removably connectable to the instrument casing. an instrument casing, including measurement components therein; a cartridge receiving cavity extending within the instrument casing, the cartridge receiving cavity having: an inner end provided with a test instrument optical port; and an outer end provided with a cartridge receiving opening, the opening being located on the instrument casing; an inner end provided with a test instrument optical port; and an outer end provided with a cartridge receiving opening, the opening being located on the instrument casing; a connector cartridge sized and configured to fit in the cartridge receiving cavity, the connector cartridge having: a cartridge inner end which faces the test instrument optical port, and a cartridge outer end which receives an optic fiber from a device under test, the connector cartridge housing a fiber optic cable extending between the cartridge inner end and the cartridge outer end, the connector cartridge being removably connectable to the instrument casing. a cartridge inner end which faces the test instrument optical port, and a cartridge outer end which receives an optic fiber from a device under test, the connector cartridge housing a fiber optic cable extending between the cartridge inner end and the cartridge outer end, the connector cartridge being removably connectable to the instrument casing.
A hot water production installation including a ventilation system, a storage tank, a clean electric power supply system delivering a variable power (Pv), and a thermodynamic circuit equipped with at least one evaporator intended to be disposed in an air flow of said ventilation system of a building, with at least one condenser disposed in the tank, and with at least one variable speed compressor, the installation including means for measuring the variable power (Pv) delivered by the clean electric power supply system, and means for regulating the speed of said at least one variable speed compressor according to the measurement provided by these means for measuring the variable power (Pv).
A flight vehicle comprising: an upstream portion; and a downstream portion aft of the upstream portion; wherein one of the portions has a local variation in surface shape, whereby the local variation in surface shape produces a shock in supersonic flow; wherein one or both of the portions have one or more holes, downstream of the shock produced by the local variation in surface shape, in fluid communication with a cavity defined at least in part by the portions, and between the portions; wherein the local variation in surface shape includes a variation in diameter providing a reduced diameter for the upstream portion at an aft end of the upstream portion, the reduced diameter being less than a relatively wide diameter of the upstream portion forward of the aft end; wherein a forward end of the downstream portion has a shoulder that extends radially out further than the aft end of the upstream portion; and wherein the shock is produced forward of the shoulder. an upstream portion; and a downstream portion aft of the upstream portion; wherein one of the portions has a local variation in surface shape, whereby the local variation in surface shape produces a shock in supersonic flow; wherein one or both of the portions have one or more holes, downstream of the shock produced by the local variation in surface shape, in fluid communication with a cavity defined at least in part by the portions, and between the portions; wherein the local variation in surface shape includes a variation in diameter providing a reduced diameter for the upstream portion at an aft end of the upstream portion, the reduced diameter being less than a relatively wide diameter of the upstream portion forward of the aft end; wherein a forward end of the downstream portion has a shoulder that extends radially out further than the aft end of the upstream portion; and wherein the shock is produced forward of the shoulder.
Device for degassing a steel melt, comprising an evacuation vessel, a casting ladle, an inlet nozzle with a gas flushing device arranged therein and an outlet nozzle, wherein the outlet nozzle has at the lower edge in radial direction referred to the centre longitudinal axis of the outlet nozzle at least one bore so as to suck up melt with carbon content from a deadwater region between the outlet nozzle and the ladle infeed and to conduct it into the downward flow of the outlet nozzle.
System for selectively switching on and off a balise arranged in a rail track comprising the balise featuring a first induction device for receiving a telepowering signal emitted by a rail vehicle and a switching circuit operable by the energy gained from the telepowering signal for emitting a balise telegram, characterized in that a second induction device is provided having a openable switch and wirelessly coupled to the first induction device, with the balise in the case of an opened switch being able to send out the balise telegram and in the case of a closed switch able to generate an inductive coupling signal in the second induction device for at least partially mitigating the induction impact of the telepowering signal so that the power still induced in the first induction device stays below an activation threshold of the switching circuit.
A scanning optical system, comprising: a mirror unit equipped with a first mirror surface and a second mirror surface each of which inclines to a rotation axis; and a light projecting system including at least one light source to emit a light flux toward the first mirror surface, wherein the scanning optical system is configured such that a light flux emitted from the light source is reflected on the first mirror surface of the mirror unit, thereafter, reflected on the second mirror surface, and then, projected so as to scan in a main scanning direction onto an object in accordance with rotation of the mirror unit, characterized in that the scanning optical system is configured such that the light flux reflected on the second mirror surface is polarized in a range within an angle (Φ) of ± 30 degrees to a direction perpendicular to the main scanning direction on the object side. a mirror unit equipped with a first mirror surface and a second mirror surface each of which inclines to a rotation axis; and a light projecting system including at least one light source to emit a light flux toward the first mirror surface, wherein the scanning optical system is configured such that a light flux emitted from the light source is reflected on the first mirror surface of the mirror unit, thereafter, reflected on the second mirror surface, and then, projected so as to scan in a main scanning direction onto an object in accordance with rotation of the mirror unit, characterized in that the scanning optical system is configured such that the light flux reflected on the second mirror surface is polarized in a range within an angle (Φ) of ± 30 degrees to a direction perpendicular to the main scanning direction on the object side.
A method of transcoding Mixed Excitation Linear Prediction (MELP) encoded speech data as speech frame rates from a first MELP voice coder (vocoder) for use at a different speech frame rate in a second MELP vocoder, which comprises: converting input data representing speech into MELP speech parameters used by the first MELP vocoder; buffering the MELP parameters; performing a time interpolation of the MELP parameters from frames of speech data with quantization; and performing an encoding function on the interpolated data as a block of bits corresponding to a frame of speech data to produce a reduction in bit-rate as used by the second MELP vocoder at a different speech frame rate than the first MELP vocoder. converting input data representing speech into MELP speech parameters used by the first MELP vocoder; buffering the MELP parameters; performing a time interpolation of the MELP parameters from frames of speech data with quantization; and performing an encoding function on the interpolated data as a block of bits corresponding to a frame of speech data to produce a reduction in bit-rate as used by the second MELP vocoder at a different speech frame rate than the first MELP vocoder.
A method of a user equipment, UE, communicating with a base station in time division duplex, TDD, communication systems, the method comprising: receiving a higher layer signal regarding downlink control information, DCI, with a cyclic redundancy check, CRC, scrambled by a radio network temporary identifier, RNTI; monitoring, on a common search space, the DCI based on a configured control channel element, CCE, aggregation level, wherein the DCI includes configuration information, per cell, associated with time resources comprising at least one of time resource with downlink, DL, direction, time resource with uplink, UL, direction and time resource with flexible direction; and communicating with the base station based on the configuration information, wherein a location of the configuration information per cell in the DCI is indicated by a higher layer parameter included in the higher layer signal. receiving a higher layer signal regarding downlink control information, DCI, with a cyclic redundancy check, CRC, scrambled by a radio network temporary identifier, RNTI; monitoring, on a common search space, the DCI based on a configured control channel element, CCE, aggregation level, wherein the DCI includes configuration information, per cell, associated with time resources comprising at least one of time resource with downlink, DL, direction, time resource with uplink, UL, direction and time resource with flexible direction; and communicating with the base station based on the configuration information, wherein a location of the configuration information per cell in the DCI is indicated by a higher layer parameter included in the higher layer signal.
A catalyst article for use in an internal combustion engine comprising: a first catalytic layer formed on a substrate, wherein the first catalytic layer comprises palladium impregnated on a ceria-free oxygen storage component and platinum impregnated on a refractory metal oxide, and; a palladium-free second catalytic layer formed on the first catalytic layer, the second catalytic layer comprising platinum and rhodium impregnated on a ceria-containing oxygen storage component, wherein the ceria-containing oxygen storage component contains refractory metal oxides in amounts of no more than 50% by weight, and non-ceria rare earth oxides in an amount of no more than 10% by weight, wherein the catalyst article is effective to reduce carbon monoxide in exhaust gas from the internal combustion engine. a first catalytic layer formed on a substrate, wherein the first catalytic layer comprises palladium impregnated on a ceria-free oxygen storage component and platinum impregnated on a refractory metal oxide, and; a palladium-free second catalytic layer formed on the first catalytic layer, the second catalytic layer comprising platinum and rhodium impregnated on a ceria-containing oxygen storage component, wherein the ceria-containing oxygen storage component contains refractory metal oxides in amounts of no more than 50% by weight, and non-ceria rare earth oxides in an amount of no more than 10% by weight, wherein the catalyst article is effective to reduce carbon monoxide in exhaust gas from the internal combustion engine.