A compound of Formula V-A: or a pharmaceutically acceptable salt thereof, wherein: T is an optionally substituted C 1 -C 2 aliphatic chain, wherein each of the carbon units is optionally and independently replaced by -CO-, -CS-, -COCO-, -SO 2 -, -B -, or -B(O(C 1 -C 6 alkyl))-; R 1 ' is independently an optionally substituted C 1 -C 6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted 3 to 10 membered cycloaliphatic, an optionally substituted 3 to 10 membered heterocycloaliphatic, carboxy, amido, amino, halo, or hydroxy; R 1 " is selected from the group consisting of H, C 1-6 aliphatic, halo, CF 3, CHF 2, and-O(C 1-6 aliphatic); R D1 is attached to carbon 3" or 4"; each R D1 and R D2 is -Z D R 9, wherein each Z D is independently a bond or an optionally substituted branched or straight C 1 -C 6 aliphatic chain wherein up to two carbon units of Z D are optionally and independently replaced by -CO-, -CS-, -CONR E -, - CONR E NR E -, -CO2-, -OCO-,-NR E CO 2 -, -O-, -NR E CONR E -, -OCONR E -, - NR E NR E -, -NR E CO-, -S-, -SO-, -SO 2 -, -NR E -, -SO 2 NR E -, -NR E SO 2 -, or - NR E SO 2 NR E -; R 9 is independently R E, halo, -OH, -NH 2, -NO 2, -CN, -CF 3, or -OCF 3; or R D1 and R D2, taken together with atoms to which they are attached, form a 3-8 membered saturated, partially unsaturated, or aromatic ring with up to 3 ring members independently selected from the group consisting of O, NH, NR E, and S; and each R E is independently hydrogen, an optionally substituted C 1 -C 8 aliphatic group, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl. T is an optionally substituted C 1 -C 2 aliphatic chain, wherein each of the carbon units is optionally and independently replaced by -CO-, -CS-, -COCO-, -SO 2 -, -B -, or -B(O(C 1 -C 6 alkyl))-; R 1 ' is independently an optionally substituted C 1 -C 6 aliphatic, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted 3 to 10 membered cycloaliphatic, an optionally substituted 3 to 10 membered heterocycloaliphatic, carboxy, amido, amino, halo, or hydroxy; R 1 " is selected from the group consisting of H, C 1-6 aliphatic, halo, CF 3, CHF 2, and-O(C 1-6 aliphatic); R D1 is attached to carbon 3" or 4"; each R D1 and R D2 is -Z D R 9, wherein each Z D is independently a bond or an optionally substituted branched or straight C 1 -C 6 aliphatic chain wherein up to two carbon units of Z D are optionally and independently replaced by -CO-, -CS-, -CONR E -, - CONR E NR E -, -CO2-, -OCO-,-NR E CO 2 -, -O-, -NR E CONR E -, -OCONR E -, - NR E NR E -, -NR E CO-, -S-, -SO-, -SO 2 -, -NR E -, -SO 2 NR E -, -NR E SO 2 -, or - NR E SO 2 NR E -; R 9 is independently R E, halo, -OH, -NH 2, -NO 2, -CN, -CF 3, or -OCF 3; or R D1 and R D2, taken together with atoms to which they are attached, form a 3-8 membered saturated, partially unsaturated, or aromatic ring with up to 3 ring members independently selected from the group consisting of O, NH, NR E, and S; and each R E is independently hydrogen, an optionally substituted C 1 -C 8 aliphatic group, an optionally substituted cycloaliphatic, an optionally substituted heterocycloaliphatic, an optionally substituted aryl, or an optionally substituted heteroaryl.