An ocular injection device, comprising: a housing defining an inner volume, a proximal end portion of the housing configured to be coupled to a medicament container, a distal end portion of the housing including a hub surface, the hub surface configured to contact a target surface of a target tissue; an adjustment member disposed within the inner volume such that the inner volume is separated into a first chamber and a second chamber, the first chamber in fluid communication with the medicament container when the proximal end portion of the housing is coupled to the medicament container, the adjustment member configured to transition within the inner volume between a first configuration and a second configuration; and a puncture member coupled to the adjustment member, a proximal end portion of the puncture member in fluid communication with the first chamber such that a substance can be conveyed from the medicament container through the puncture member via the first chamber, a distal tip of the puncture member extending from the hub surface by a first distance when the adjustment member is in the first configuration, the distal tip of the puncture member extending from the hub surface by a second distance when the adjustment member is in the second configuration, the second distance greater than the first distance, wherein: the adjustment member includes a seal member in sliding contact with an inner surface of the housing, the seal member fluidically isolating the first chamber from the second chamber; and the adjustment member is configured to move from a first position to a second position when the adjustment member transitions within the inner volume from the first configuration towards the second configuration. a housing defining an inner volume, a proximal end portion of the housing configured to be coupled to a medicament container, a distal end portion of the housing including a hub surface, the hub surface configured to contact a target surface of a target tissue; an adjustment member disposed within the inner volume such that the inner volume is separated into a first chamber and a second chamber, the first chamber in fluid communication with the medicament container when the proximal end portion of the housing is coupled to the medicament container, the adjustment member configured to transition within the inner volume between a first configuration and a second configuration; and a puncture member coupled to the adjustment member, a proximal end portion of the puncture member in fluid communication with the first chamber such that a substance can be conveyed from the medicament container through the puncture member via the first chamber, a distal tip of the puncture member extending from the hub surface by a first distance when the adjustment member is in the first configuration, the distal tip of the puncture member extending from the hub surface by a second distance when the adjustment member is in the second configuration, the second distance greater than the first distance, wherein: the adjustment member includes a seal member in sliding contact with an inner surface of the housing, the seal member fluidically isolating the first chamber from the second chamber; and the adjustment member is configured to move from a first position to a second position when the adjustment member transitions within the inner volume from the first configuration towards the second configuration. the adjustment member includes a seal member in sliding contact with an inner surface of the housing, the seal member fluidically isolating the first chamber from the second chamber; and the adjustment member is configured to move from a first position to a second position when the adjustment member transitions within the inner volume from the first configuration towards the second configuration.