A compound of Formula IA: or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein " ----- " represents a single or double bond; R° is selected from hydrogen and C 1-6 alkyl; R 1 is selected from cyano, 6-membered heterocycloalkyl, 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R 1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C 1-6 alkyl, C 1-6 haloalkyl, -C R 13, -C OR 13, -NR 14a R 14b, 5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein R 13 is selected from C 1-6 alkyl, amino, and C 1-6 alkylamino; R 14a and R 14b are each independently selected from hydrogen, C 1-6 alkyl, -C R 15, -C OR 15, and -S 2 R 15, wherein R 15 is hydrogen or C 1-6 alkyl; and the heterocycloalkyl, phenyl or heteroaryl substituent of R 1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C 1-6 alkyl, and C 1-6 haloalkyl; R 3 is selected from 5- and 6-membered cycloalkyl, 5- and 6-membered heterocycloalkyl, 6- and 10-membered heterocyclyl, phenyl, and 5- and 6-membered heteroaryl, wherein the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R 3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -C R 16, -C OR 16, - S 2 R 16, 5- and 6-membered heterocycloalkyl, and phenyl; wherein R 16 is hydrogen or C 1-6 alkyl; the phenyl or heterocycloalkyl substituent of R 3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and R 2 and R 4 are each hydrogen or C 1-6 alkyl; or R 2 and R 4 taken together form a cyclopropyl ring fused to the bicyclic ring; or R 2 and R 4 taken together form a bond producing a double bond between the two carbons to which R 2 and R 4 are attached; R 5 is hydrogen or C 1-6 alkyl, or R 5 and R 10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring; R 6 and R 7 are each hydrogen or C 1-6 alkyl; or R 6 and R 7 taken together form a bond producing a double bond between the two carbons to which R 6 and R 7 are attached; and R 10 is hydrogen or C 1-6 alkyl. or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein " ----- " represents a single or double bond; R° is selected from hydrogen and C 1-6 alkyl; R 1 is selected from cyano, 6-membered heterocycloalkyl, 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R 1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C 1-6 alkyl, C 1-6 haloalkyl, -C R 13, -C OR 13, -NR 14a R 14b, 5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein R 13 is selected from C 1-6 alkyl, amino, and C 1-6 alkylamino; R 14a and R 14b are each independently selected from hydrogen, C 1-6 alkyl, -C R 15, -C OR 15, and -S 2 R 15, wherein R 15 is hydrogen or C 1-6 alkyl; and the heterocycloalkyl, phenyl or heteroaryl substituent of R 1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C 1-6 alkyl, and C 1-6 haloalkyl; R 13 is selected from C 1-6 alkyl, amino, and C 1-6 alkylamino; R 14a and R 14b are each independently selected from hydrogen, C 1-6 alkyl, -C R 15, -C OR 15, and -S 2 R 15, wherein R 15 is hydrogen or C 1-6 alkyl; and the heterocycloalkyl, phenyl or heteroaryl substituent of R 1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C 1-6 alkyl, and C 1-6 haloalkyl; R 3 is selected from 5- and 6-membered cycloalkyl, 5- and 6-membered heterocycloalkyl, 6- and 10-membered heterocyclyl, phenyl, and 5- and 6-membered heteroaryl, wherein the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R 3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -C R 16, -C OR 16, - S 2 R 16, 5- and 6-membered heterocycloalkyl, and phenyl; wherein R 16 is hydrogen or C 1-6 alkyl; the phenyl or heterocycloalkyl substituent of R 3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and R 16 is hydrogen or C 1-6 alkyl; the phenyl or heterocycloalkyl substituent of R 3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and R 2 and R 4 are each hydrogen or C 1-6 alkyl; or R 2 and R 4 taken together form a cyclopropyl ring fused to the bicyclic ring; or R 2 and R 4 taken together form a bond producing a double bond between the two carbons to which R 2 and R 4 are attached; R 5 is hydrogen or C 1-6 alkyl, or R 5 and R 10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring; R 6 and R 7 are each hydrogen or C 1-6 alkyl; or R 6 and R 7 taken together form a bond producing a double bond between the two carbons to which R 6 and R 7 are attached; and R 10 is hydrogen or C 1-6 alkyl.