mhurhangee/ep-ind-claims huggingface dataset:
Pharmaceutical composition comprising as active substance an isolated mutated feline lentiviral ENV protein, or a fragment thereof, that has lost at least 50%, at least 75% or 100% of its immunosuppressive activity in comparison to the immunosuppressive activity of the wild type Env protein, said fragment of said isolated mutated feline lentiviral ENV protein comprising at least 40 amino acids, in particular at least 60 amino acids, said mutated feline lentiviral ENV protein resulting from mutation of the transmembrane subunit of a wild type feline lentiviral ENV protein, said mutated ENV protein having at least 70% identity, preferably at least 80% identity, to the sequence SEQ ID NO: 5, said mutated feline lentiviral ENV protein or fragment thereof comprising a mutated immunosuppressive domain containing the following amino acid sequence: A-[I/M/T/L]-X 1 -X 2 -X 3 -X 4 -X 5 -T-A (SEQ ID NO: 1), wherein, X 1 is R, X 2 is K, X 3 is F or P, X 4 is L or V or I and X 5 is Y, or X 2 is R, X 1 is E, X 3 is F or P, X 4 is L or V or I and X 5 is Y, or X 3 is R, X 1 is E, X 2 is K, X 4 is L or V or I and X 5 is Y, or X 4 is R, X 1 is E, X 2 is K, X 3 is F or P and X 5 is Y, or X 5 is R, X 1 is E, X 2 is K, X 3 is F or P and X 4 is L or V or I, which respectively correspond to the following amino acid sequence: A-[I/M/T/L]-R-K-[F/P]-[LN/I]-Y-T-A (SEQ ID NO: 497), or A-[I/M/T/L]-E-R-[F/P]-[L/V/I]-Y-T-A (SEQ ID NO: 498), or A-[I/M/T/L]-E-K-R-[L/V/I]-Y-T-A (SEQ ID NO: 499), or A-[I/M/T/L]-E-K-[F/P]-R-Y-T-A (SEQ ID NO: 500), or A-[I/M/T/L]-E-K-[F/P]-[L/V/I]-R-T-A (SEQ ID NO: 501), in association with a pharmaceutically acceptable carrier, said loss of at least 50%, at least 75% or 100% of its immunosuppressive activity of the above mentioned mutated feline lentiviral ENV protein or of the above defined fragment being liable to be assessed by the fact that in an in vivo assay involving engrafted tumor cells rejection, in animals excluding human beings, said tumor cells being transduced either so as to express said mutated ENV protein or said fragment (mutated ENV tumor cells), or said tumor cells being transduced so as to express said wild type ENV protein or a fragment thereof (wild type ENV tumor cells), or said tumor cells being not transduced (normal tumor cells), the following ratio: immunosuppression index of said mutated ENV protein or of said fragment i mutated env immunosuppression index of wild type ENV protein i wild type env is less than 0.5, or even less than 0.25, i mutated env being defined by: maximum area reached by mutated ENV tumor cells − maximum area reached by normal tumor cells maximum area reached by normal tumor cells, and i wild type env being defined by: maximum area reached by wild type ENV tumor cells − maximum area reached by normal tumor cells maximum area reached by normal tumor cells. A-[I/M/T/L]-R-K-[F/P]-[LN/I]-Y-T-A (SEQ ID NO: 497), or A-[I/M/T/L]-E-R-[F/P]-[L/V/I]-Y-T-A (SEQ ID NO: 498), or A-[I/M/T/L]-E-K-R-[L/V/I]-Y-T-A (SEQ ID NO: 499), or A-[I/M/T/L]-E-K-[F/P]-R-Y-T-A (SEQ ID NO: 500), or A-[I/M/T/L]-E-K-[F/P]-[L/V/I]-R-T-A (SEQ ID NO: 501),
A neonatal bovine dietary supplement in liquid form that delivers a dosage of naturally occurring caffeine that is formulated with a viscosity of 400 - 800 centipoise at 21 degrees Celsius such that the supplement is absorbed through the oral mucosal lining of a neonatal calf.
Use of a casting nozzle in a magnesium or magnesium alloy twin roll casting method, wherein: the casting nozzle, which supplies molten metal of pure magnesium or magnesium alloy into a twin roll movable casting die, comprises: a molten metal contact portion which comes into contact with the molten metal; a casting die contact portion formed of thermal insulation material which comes into contact with the movable casting die; and a pouring port from which the molten metal is poured into the movable casting.die, wherein at least a part of the molten metal contact part is formed of a material having an oxygen content of 20 mass% or less, and wherein a leading end of the nozzle at which the pouring port is provided is in contact with the rolls so that the nozzle leading end is put between the rolls. the casting nozzle, which supplies molten metal of pure magnesium or magnesium alloy into a twin roll movable casting die, comprises: a molten metal contact portion which comes into contact with the molten metal; a casting die contact portion formed of thermal insulation material which comes into contact with the movable casting die; and a pouring port from which the molten metal is poured into the movable casting.die, wherein at least a part of the molten metal contact part is formed of a material having an oxygen content of 20 mass% or less, and wherein a leading end of the nozzle at which the pouring port is provided is in contact with the rolls so that the nozzle leading end is put between the rolls. a molten metal contact portion which comes into contact with the molten metal; a casting die contact portion formed of thermal insulation material which comes into contact with the movable casting die; and a pouring port from which the molten metal is poured into the movable casting.die, wherein at least a part of the molten metal contact part is formed of a material having an oxygen content of 20 mass% or less, and wherein a leading end of the nozzle at which the pouring port is provided is in contact with the rolls so that the nozzle leading end is put between the rolls.
A hot water meter installable in each individual household in a central hot water system which produces warm water by heating raw water with a heat exchanger and supplies the warm water to the each individual household, the hot water meter comprising: a raw water temperature receiving unit adapted for receiving a measurement value Tcm of a temperature of the raw water via communication with a raw water temperature measuring unit, said raw water temperature measuring unit being adapted for measuring the temperature of the raw water supplied to the heat exchanger; a hot water flow rate measuring unit adapted for measuring a flow rate of the hot water flowing through the hot water meter; a hot water temperature measuring unit adapted for measuring a temperature of the hot water; and a hot water heating value calculating unit adapted for calculating a heating value of the hot water by multiplying a difference value between the temperature of the hot water and the temperature of the raw water by the flow rate of the hot water, characterized by a raw water temperature estimating unit adapted for estimating the temperature Tce of the raw water by using a record of the temperature of the raw water stored according to the measurement value of the temperature of the raw water which is received; wherein, when the raw water temperature receiving unit fails to receive the measurement value Tcm of the temperature of the raw water, the hot water heating value calculating unit calculates the heating value of the hot water by using an estimation value of the temperature of the raw water estimated by the raw water temperature estimating unit. a raw water temperature receiving unit adapted for receiving a measurement value Tcm of a temperature of the raw water via communication with a raw water temperature measuring unit, said raw water temperature measuring unit being adapted for measuring the temperature of the raw water supplied to the heat exchanger; a hot water flow rate measuring unit adapted for measuring a flow rate of the hot water flowing through the hot water meter; a hot water temperature measuring unit adapted for measuring a temperature of the hot water; and a hot water heating value calculating unit adapted for calculating a heating value of the hot water by multiplying a difference value between the temperature of the hot water and the temperature of the raw water by the flow rate of the hot water, characterized by a raw water temperature estimating unit adapted for estimating the temperature Tce of the raw water by using a record of the temperature of the raw water stored according to the measurement value of the temperature of the raw water which is received; wherein, when the raw water temperature receiving unit fails to receive the measurement value Tcm of the temperature of the raw water, the hot water heating value calculating unit calculates the heating value of the hot water by using an estimation value of the temperature of the raw water estimated by the raw water temperature estimating unit.
A method of determining the amount of adenosine monophosphate in a solution comprising: i) converting substantially all AMP in the solution to adenosine diphosphate using a first enzyme that is capable of converting AMP to ADP, wherein the first enzyme is polyphosphate:AMP phosphotransferase; ii) converting substantially all the ADP in the solution to adenosine triphosphate using a second enzyme that is capable of converting ADP to ATP, wherein the second enzyme is adenylate kinase; iii) after step (ii) determining the amount of the ATP produced in step (ii) using a bioluminescent reaction utilizing a luciferase enzyme and a substrate for the luciferase enzyme. iv) using the amount of ATP produced to determine the amount of AMP present in the solution before step (i); wherein before step (i) there is a step of converting at least 95% of all adenosine triphosphate in the solution to cyclic adenosine monophosphate (cAMP) and pyrophosphate with adenylate cyclase. i) converting substantially all AMP in the solution to adenosine diphosphate using a first enzyme that is capable of converting AMP to ADP, wherein the first enzyme is polyphosphate:AMP phosphotransferase; ii) converting substantially all the ADP in the solution to adenosine triphosphate using a second enzyme that is capable of converting ADP to ATP, wherein the second enzyme is adenylate kinase; iii) after step (ii) determining the amount of the ATP produced in step (ii) using a bioluminescent reaction utilizing a luciferase enzyme and a substrate for the luciferase enzyme. iv) using the amount of ATP produced to determine the amount of AMP present in the solution before step (i);
A gas-fired barbecue grill cooking system comprising: a firebox; a burner assembly (132, 180, 210) mounted within the firebox, the burner assembly (132, 180, 210) having a first burner tube (184, 186, 214, 215, 216, 217) defining a first cooking zone and a second burner tube (184, 186, 214, 215, 216, 217) defining a second cooking zone; and a gas control assembly (202, 222) having a gas control valve (200, 220, 300) and a control actuator (160, 224), wherein the gas control valve (200, 220, 300) being configured, in response to positioning of the control actuator (160, 224), to selectively control a first flow of gas to the first burner tube (184, 186, 214, 215, 216, 217) and a second flow of gas to the second burner tube (184, 186, 214, 215, 216, 217) such that the first cooking zone and the second cooking zone are operable to be heated independently in a first mode, in which only one of the first cooking zone and the second cooking zone is heated, and heated simultaneously in a second mode, and, characterized in that the control actuator (160, 224) comprises a control knob and a selector ring, each of which is rotatable about a common axis; the selector ring being configured to designate, via rotation, at least one of the first burner tube (184, 186, 214, 215, 216, 217) or the second burner tube (184, 186, 214, 215, 216, 217) for receiving a corresponding flow of gas; and the control knob being configured to set a flow rate of gas to the at least of the first burner tube (184, 186, 214, 215, 216, 217) or the second burner tube (184, 186, 214, 215, 216, 217) designated with the selector ring. a firebox; a burner assembly (132, 180, 210) mounted within the firebox, the burner assembly (132, 180, 210) having a first burner tube (184, 186, 214, 215, 216, 217) defining a first cooking zone and a second burner tube (184, 186, 214, 215, 216, 217) defining a second cooking zone; and a gas control assembly (202, 222) having a gas control valve (200, 220, 300) and a control actuator (160, 224), wherein the gas control valve (200, 220, 300) being configured, in response to positioning of the control actuator (160, 224), to selectively control a first flow of gas to the first burner tube (184, 186, 214, 215, 216, 217) and a second flow of gas to the second burner tube (184, 186, 214, 215, 216, 217) such that the first cooking zone and the second cooking zone are operable to be heated independently in a first mode, in which only one of the first cooking zone and the second cooking zone is heated, and heated simultaneously in a second mode, and, characterized in that the control actuator (160, 224) comprises a control knob and a selector ring, each of which is rotatable about a common axis; the selector ring being configured to designate, via rotation, at least one of the first burner tube (184, 186, 214, 215, 216, 217) or the second burner tube (184, 186, 214, 215, 216, 217) for receiving a corresponding flow of gas; and the control knob being configured to set a flow rate of gas to the at least of the first burner tube (184, 186, 214, 215, 216, 217) or the second burner tube (184, 186, 214, 215, 216, 217) designated with the selector ring.
A controlled release fertilizer material comprising a particulate plant nutrient surrounded by at least one coating comprising the reaction product of a mixture comprising a polyol, an isocyanate, a wax and an epoxidized fatty acid triglyceride oil, wherein the epoxidized fatty acid triglyceride oil is present in an amount of from 0.1 to 70 percent by weight based on the total coating weight and wherein the epoxidized fatty acid triglyceride oil is and wax is present in the coating in an amount of from 0.1 to 75 percent by combined weight based on the total coating weight.
Power semiconductor component comprising a semiconductor base body (2, 4) having a first doping, a contact region having a second doping with a first doping profile, said contact region being formed in said base body in a trench-type cutout and forming a pn junction with the region having the first doping, and a field ring structure having a second doping with a second doping profile of the respective field ring, wherein the penetration depth of the first and second doping profiles (120, 140) are identical, wherein the contact region and the field ring structure are arranged at respectively assigned first and second partial areas of a first surface of the base body and extend into the volume of the base body, and wherein the base body (2, 4) has, for the field ring structure, a trench-type cutout assigned to the respective field ring, a surface of said cutout essentially following the contour of the assigned doping profile, wherein the first doping is embodied as n-doping and the second doping is embodied as p-doping, wherein the power semiconductor component is embodied as a power diode, characterized in that the power semiconductor component has a basic area in the range of between 10 mm 2 and 100 mm 2, wherein the thickness of the power semiconductor component is between 100 μm und 450 μm, wherein the penetration depth of the second doping (120, 140) is between 10 μm and 30 μm, wherein the depth extent of the respective trench-type cutout (122, 142) is a maximum of 90 per cent and a minimum of 50 per cent of the penetration depth of the second doping, wherein the region of the second doping of the field rings has a concentration of 10 15 to 10 16 cm -3 at the surface, wherein the lateral extent of the trench-type cutout of the assigned field rings with respect to the depth extent has a ratio of 1:3 to 3:1.
A hydraulic transmission comprising: a hydraulic pump configured to be driven by a mechanical energy which is inputted to a rotation shaft; a plurality of hydraulic motors (14A,14B) each of which has a variable displacement and is configured to be driven by a pressurized oil from the hydraulic pump; and a controller for controlling a displacement of each of the hydraulic motors (14A,14B), wherein the controller includes: a total displacement determination unit for determining a total displacement D total of the hydraulic motors (14A,14B); a displacement distribution unit configured to distribute the total displacement D total to each of the hydraulic motors (14A,14B) based on a motor information which indicates at least one of an inherent property or an operation state of each of the hydraulic motors (14A,14B) and to determine the displacement of each of the hydraulic motors (14A,14B); a command output unit which is configured to output a command for each of the hydraulic motors (14A,14B) so as to achieve the displacement determined by the displacement distributing unit; characterized in that the controller includes an operation state information obtaining unit which is configured to obtain an operation state information including a vibration information, said operation state information indicating the operation state of each of the hydraulic motors (14A,14B) while the hydraulic transmission is operated, the operation state information includes a vibration information which indicates a vibration of each of the hydraulic motors (14A,14B), and the displacement distribution unit is configured to determine the displacement of each of the hydraulic motors (14A,14B) based on at least the vibration information so that an amplitude or a frequency of the vibration of each of the hydraulic motors (14A,14B) is within an tolerable range. a hydraulic pump configured to be driven by a mechanical energy which is inputted to a rotation shaft; a plurality of hydraulic motors (14A,14B) each of which has a variable displacement and is configured to be driven by a pressurized oil from the hydraulic pump; and a controller for controlling a displacement of each of the hydraulic motors (14A,14B), a total displacement determination unit for determining a total displacement D total of the hydraulic motors (14A,14B); a displacement distribution unit configured to distribute the total displacement D total to each of the hydraulic motors (14A,14B) based on a motor information which indicates at least one of an inherent property or an operation state of each of the hydraulic motors (14A,14B) and to determine the displacement of each of the hydraulic motors (14A,14B); a command output unit which is configured to output a command for each of the hydraulic motors (14A,14B) so as to achieve the displacement determined by the displacement distributing unit;
A composition with antimicrobial activity which also promotes the remineralization of the surface of tooth enamel and dentin, wherein the composition comprises at least: a) an inorganic antimicrobial agent; b) a promoter agent of remineralization of a surface of tooth enamel and dentin being composed by an ammonia complex of copper whose counter ion is fluoride Cu(NH 3) 6)F 2 at a pH between 8 and 12; c) an inhibitor agent of the demineralization of tooth enamel and dentin; and d) a stabilizing agent which has antimicrobial properties and also helps the remineralization is selected among derivates from graphene and/or graphite, more specifically graphite oxides and graphene oxides. a) an inorganic antimicrobial agent; b) a promoter agent of remineralization of a surface of tooth enamel and dentin being composed by an ammonia complex of copper whose counter ion is fluoride Cu(NH 3) 6)F 2 at a pH between 8 and 12; c) an inhibitor agent of the demineralization of tooth enamel and dentin; and d) a stabilizing agent which has antimicrobial properties and also helps the remineralization is selected among derivates from graphene and/or graphite, more specifically graphite oxides and graphene oxides.
A method for pre-provisioning validated database snapshots, the method comprising: receiving a plurality of database blocks corresponding to a source database; storing the database blocks on a storage system; receiving transaction logs from the source database corresponding to transactions executed in the source database; creating multiple recovery milestones based on a predefined schedule, the recovery milestones being created in advance of receiving a request for provisioning a virtual database, each recovery milestone comprising database blocks from which a consistent snapshot of the source database corresponding to a point in time can be created, wherein at least some of the database blocks are associated with multiple recovery milestones, the creating of each recovery milestone comprising: applying a set of transaction logs to either a plurality of database blocks received from the source database or a plurality of database blocks of a previously created recovery milestone and validating the recovery milestone created to determine whether the recovery milestone can be used to create a consistent snapshot of the source database; receiving a request for provisioning the virtual database corresponding to a point in time; and responsive to receiving the request to provision the virtual database, identifying a recovery milestone corresponding to the point in time, and provisioning the requested virtual database based on the recovery milestone. receiving a plurality of database blocks corresponding to a source database; storing the database blocks on a storage system; receiving transaction logs from the source database corresponding to transactions executed in the source database; creating multiple recovery milestones based on a predefined schedule, the recovery milestones being created in advance of receiving a request for provisioning a virtual database, each recovery milestone comprising database blocks from which a consistent snapshot of the source database corresponding to a point in time can be created, wherein at least some of the database blocks are associated with multiple recovery milestones, the creating of each recovery milestone comprising: applying a set of transaction logs to either a plurality of database blocks received from the source database or a plurality of database blocks of a previously created recovery milestone and validating the recovery milestone created to determine whether the recovery milestone can be used to create a consistent snapshot of the source database; applying a set of transaction logs to either a plurality of database blocks received from the source database or a plurality of database blocks of a previously created recovery milestone and validating the recovery milestone created to determine whether the recovery milestone can be used to create a consistent snapshot of the source database; receiving a request for provisioning the virtual database corresponding to a point in time; and responsive to receiving the request to provision the virtual database, identifying a recovery milestone corresponding to the point in time, and provisioning the requested virtual database based on the recovery milestone.