A compound of the following general formula: or a pharmaceutically acceptable salt and/or solvate thereof, wherein: • is • when is X 1 is a nitrogen atom and -X 2 is -N-Y, • when is -X 1 is -N-Y and X 2 is a nitrogen atom, • Y is -C NR 10 R 11; -C R 12; -S 2 R 25; -C OR 29 or -SO 2 -NR 30 R 31; • Z is a (C 1 -C 6)alkyl and R 1 is H, halo, (C 1 -C 6)alkyl, -OR 51, CF 3, -NR 52 R 53,-OS 2 NR 54 R 55 or -CN; or Z and R 1 together form a heterocycloalkyl; • R 2 to R 4 are, independently of one another, H, halo, (C 1 -C 6)alkyl, -OR 51, -CF 3,-NR 52 R 53, -OS 2 NR 54 R 55 or -CN; • R 5 is H, (C 1 -C 6)alkyl or -O-(C 1 -C 6)alkyl; • R 6 to R 8 are, independently of one another, H; halo; -OR 56; -NR 57 R 58;-C NR 59 R 60; -C R 61; -R 62 C O 63; -R 64 C R 65; -R 66 NR 67 R 68; -R 69 OR 70;-S 2 R 74; -OR 75 C OR 76; -OC R 77; -C OR 78; or a group selected from (C 1 -C 6)alkyl, heterocycloalkyl, aryl, heteroaryl, -(C 1 -C 6)alkyl-aryl, -(C 1 -C 6)alkylheterocycloalkyl, said group being optionally substituted with one or several groups selected from halo, -OR 79, -NR 80 R 81, -SR 82, -S R 83, -SO 2 R 84, -SO 2 NR 85 R 86,-OCOR 87, -NR 88 COR 89, -NR 90 C OR 91, -CO 2 R 92, -CONR 93 R 94, -CO 2 R 95,-OCONR 96 R 97, -COR 98, nitro (-NO 2), cyano (-CN) and oxo (=O); and • R 10 to R 12, R 25, R 29 to R 31 and R 51 to R 98 are, independently of one another, H; halo; or a group selected from (C 1 -C 6)alkyl, aryl, heteroaryl, heterocycloalkyl and -(C 1 -C 6)alkyl-aryl, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, -C R alk, -C OR alk, -SO 2 R alk, -OR alk,-COR alk R alk ', oxo (=O), and SO 2 -R alk, wherein R alk and R alk are, independently of each other, (C 1 -C 6)alkyl; or R 57 -R 58, R 59 -R 60, R 67 -R 68, R 80 -R 81, R 85 -R 86, R 93 -R 94, and/or R 96 -R 97 respectively form together a heterocycloalkyl group; with the proviso that: when is and Z is a methyl, Y is not -SO 2 -phenyl. • is • when is X 1 is a nitrogen atom and -X 2 is -N-Y, • when is -X 1 is -N-Y and X 2 is a nitrogen atom, • Y is -C NR 10 R 11; -C R 12; -S 2 R 25; -C OR 29 or -SO 2 -NR 30 R 31; • Z is a (C 1 -C 6)alkyl and R 1 is H, halo, (C 1 -C 6)alkyl, -OR 51, CF 3, -NR 52 R 53,-OS 2 NR 54 R 55 or -CN; or Z and R 1 together form a heterocycloalkyl; • R 2 to R 4 are, independently of one another, H, halo, (C 1 -C 6)alkyl, -OR 51, -CF 3,-NR 52 R 53, -OS 2 NR 54 R 55 or -CN; • R 5 is H, (C 1 -C 6)alkyl or -O-(C 1 -C 6)alkyl; • R 6 to R 8 are, independently of one another, H; halo; -OR 56; -NR 57 R 58;-C NR 59 R 60; -C R 61; -R 62 C O 63; -R 64 C R 65; -R 66 NR 67 R 68; -R 69 OR 70;-S 2 R 74; -OR 75 C OR 76; -OC R 77; -C OR 78; or a group selected from (C 1 -C 6)alkyl, heterocycloalkyl, aryl, heteroaryl, -(C 1 -C 6)alkyl-aryl, -(C 1 -C 6)alkylheterocycloalkyl, said group being optionally substituted with one or several groups selected from halo, -OR 79, -NR 80 R 81, -SR 82, -S R 83, -SO 2 R 84, -SO 2 NR 85 R 86,-OCOR 87, -NR 88 COR 89, -NR 90 C OR 91, -CO 2 R 92, -CONR 93 R 94, -CO 2 R 95,-OCONR 96 R 97, -COR 98, nitro (-NO 2), cyano (-CN) and oxo (=O); and • R 10 to R 12, R 25, R 29 to R 31 and R 51 to R 98 are, independently of one another, H; halo; or a group selected from (C 1 -C 6)alkyl, aryl, heteroaryl, heterocycloalkyl and -(C 1 -C 6)alkyl-aryl, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6)alkyl, -C R alk, -C OR alk, -SO 2 R alk, -OR alk,-COR alk R alk ', oxo (=O), and SO 2 -R alk, wherein R alk and R alk are, independently of each other, (C 1 -C 6)alkyl; or R 57 -R 58, R 59 -R 60, R 67 -R 68, R 80 -R 81, R 85 -R 86, R 93 -R 94, and/or R 96 -R 97 respectively form together a heterocycloalkyl group; with the proviso that: when is and Z is a methyl, Y is not -SO 2 -phenyl.