mhurhangee/ep-ind-claims huggingface dataset:
A method of altering a eukaryotic non-human germline cell of an organism comprising introducing into the germline cell a first foreign nucleic acid sequence encoding an RNA guided DNA binding protein nuclease and one or more guide RNAs, and including corresponding promoter sequences and a first flanking sequence and a second flanking sequence, wherein the one or more guide RNAs are complementary to one or more target locations on genomic DNA of a first chromosome and a second chromosome of a chromosome pair of the germline cell, wherein the nucleic acid sequence encoding the RNA guided DNA binding protein nuclease and the nucleic acid sequence encoding the one or more guide RNAs are between the first flanking sequence and the second flanking sequence, wherein the first flanking sequence includes a first sequence identical to a first portion of the target location on the first chromosome or the second chromosome of the genomic DNA, wherein the second flanking sequence includes a second sequence identical to a second portion of the target location on the first chromosome or the second chromosome of the genomic DNA, expressing the first foreign nucleic acid sequence to produce the RNA guided DNA binding protein nuclease and the one or more guide RNAs wherein the RNA guided DNA binding protein nuclease and an associated guide RNA co-localize to an associated target location on the first chromosome of the genomic DNA and the second chromosome of the genomic DNA and the RNA guided DNA binding protein nuclease cleaves the first chromosome of the genomic DNA at the target location in a cleavage site specific manner and cleaves the second chromosome of the genomic DNA at the target location in a cleavage site specific manner, inserting the first foreign nucleic acid sequence into the first chromosome of the chromosome pair of the genomic DNA at the cleavage site, and inserting the first foreign nucleic acid sequence into the second chromosome of the chromosome pair of the genomic DNA at the cleavage site to render the germline cell homozygous for the foreign nucleic acid sequence, and further comprising introducing into the germline cell a second foreign nucleic acid sequence encoding an RNA guided DNA binding protein nuclease and one or more guide RNAs, and including corresponding promoter sequences and a first flanking sequence and a second flanking sequence, wherein the one or more guide RNAs are complementary to the one or more target locations that were altered by the first foreign nucleic acid sequence, expressing the second foreign nucleic acid sequence to produce the RNA guided DNA binding protein nuclease and the one or more guide RNAs wherein the RNA guided DNA binding protein nuclease and an associated guide RNA co-localize to an associated target location on the chromosome of the genomic DNA and the RNA guided DNA binding protein nuclease cleaves the chromosome of the genomic DNA at the target location in a cleavage site specific manner to remove the first foreign nucleic acid sequence, and inserting the second foreign nucleic acid sequence into the chromosome of the genomic DNA at the cleavage site.
A process for preparing C 2 to C 5 olefins, comprising: introducing a feed stream comprising hydrogen and at least one carbon-containing component selected from the group consisting of CO and mixtures of CO and CO 2 into a reaction zone; contacting the feed stream with a hybrid catalyst in the reaction zone, wherein the hybrid catalyst comprises a methanol synthesis component and a solid microporous acid component that is selected from molecular sieves having 8-MR access and having a framework type selected from the group consisting of the following framework types CHA, AEI, AFX, ERI, LTA, UFI, RTH, and combinations thereof, the framework types corresponding to the naming convention of the International Zeolite Association, wherein the methanol synthesis component comprises a metal oxide support impregnated with a metal catalyst, wherein the metal oxide support comprises titania, zirconia, hafnia or mixtures thereof, and the metal catalyst comprises zinc; and forming a product stream that exits the reaction zone, wherein the product stream comprises C 2 to C 5 olefins.
A unitary RF connector, intended to link two printed circuit boards (PCB1, PCB2), comprising: - a central rigid RF line comprising a conductive element (30, 40, 50) retained within an electrical insulating body which is rigid and which comprises two end faces (21, 22); - at least one flexible RF line (B1, B2) comprising a conductive element linked to the conductive element of the central rigid line and being able to flex toward one of the end face (21, 22) of the insulating body taking any closer position when acted upon by a pressure force of a complementary connection element (PCB1, PCB2), characterised in that the unitary RF connector comprises an electromagnetic shield of the central rigid RF line, which is retained outside and surrounding the insulating body, the shield comprising flexible cuts or tabs made in lateral ends of said electromagnetic shield allowing a floating mounting of the unitary RF connector into a holder. - a central rigid RF line comprising a conductive element (30, 40, 50) retained within an electrical insulating body which is rigid and which comprises two end faces (21, 22); - at least one flexible RF line (B1, B2) comprising a conductive element linked to the conductive element of the central rigid line and being able to flex toward one of the end face (21, 22) of the insulating body taking any closer position when acted upon by a pressure force of a complementary connection element (PCB1, PCB2),
A method of decoding a sequence of at least two instructions of a data processing program into a sequence of code words used to control a data path (31, 41), wherein said sequence of at least two instructions forms a loop body of said data processing program, said method comprising the steps of: a) separating an invariant code word portion which does not change in said sequence of code words; and b) using said invariant code word portion to configure a part of said data path (31, 41) to be fixed during said sequence of code words, said method being characterized by the step of using a configuration mask register for controlling a control word loading means, so as to load the bits in the variant code portion of said sequence of code words into the appropriate bit positions of a control register. a) separating an invariant code word portion which does not change in said sequence of code words; and b) using said invariant code word portion to configure a part of said data path (31, 41) to be fixed during said sequence of code words, said method being characterized by the step of using a configuration mask register for controlling a control word loading means, so as to load the bits in the variant code portion of said sequence of code words into the appropriate bit positions of a control register.
A method for determining a local contrast value for a digital image captured by an image sensor in a camera, the method comprising: applying an edge detection algorithm to image data of the digital image, thereby obtaining a data set pertaining to edges in the digital image; calculating, based on said data set, an edge occurrence value for the digital image; estimating, based on image data of the digital image and a noise model of the image sensor, image sensor noise for the digital image, estimating, based on the estimated image sensor noise, an expected value of edge occurrence, computing the local contrast value as a relationship between the edge occurrence value of the digital image and the estimated expected value of edge occurrence. applying an edge detection algorithm to image data of the digital image, thereby obtaining a data set pertaining to edges in the digital image; calculating, based on said data set, an edge occurrence value for the digital image; estimating, based on image data of the digital image and a noise model of the image sensor, image sensor noise for the digital image, estimating, based on the estimated image sensor noise, an expected value of edge occurrence, computing the local contrast value as a relationship between the edge occurrence value of the digital image and the estimated expected value of edge occurrence.
A wind turbine blade tester comprising: a pair of linearly reciprocable actuators each arranged to deliver a stroke to a wind turbine blade being tested; characterised in that the actuators are arranged to be connected to the ground, and in that the actuators are each inclined at an angle relative to the wind turbine blade being tested whereby the stroke delivered by each of the actuators provides a controlled force in both the edgewise and flapwise directions. a pair of linearly reciprocable actuators each arranged to deliver a stroke to a wind turbine blade being tested; characterised in that the actuators are arranged to be connected to the ground, and in that the actuators are each inclined at an angle relative to the wind turbine blade being tested whereby the stroke delivered by each of the actuators provides a controlled force in both the edgewise and flapwise directions.
A method for producing shaped bodies from a building material by means of an additive manufacturing method, in which during a construction process, a layerwise construction of a shaped body takes place by successively solidifying layers of the building material through the action of electromagnetic radiation in a layer area having a contour specified for the respective layer, wherein in the construction process together with the shaped body, a sleeve-like frame surrounding the shaped body at a distance is constructed layer by layer from the building material, and wherein in addition in the construction process, a plurality of pin-like connections is constructed integral with the frame and the shaped body, which are distributed around the shaped body and which connect the shaped body with the frame, characterized in that the shaped body is a tooth replacement part, such as a tooth crown, and the pin-like connections which connect the tooth replacement part to the frame are constructed on the oral or vestibular surfaces of the tooth replacement part. wherein in the construction process together with the shaped body, a sleeve-like frame surrounding the shaped body at a distance is constructed layer by layer from the building material, and wherein in addition in the construction process, a plurality of pin-like connections is constructed integral with the frame and the shaped body, which are distributed around the shaped body and which connect the shaped body with the frame, characterized in that the shaped body is a tooth replacement part, such as a tooth crown, and the pin-like connections which connect the tooth replacement part to the frame are constructed on the oral or vestibular surfaces of the tooth replacement part.
An aerostructure assembly (50; 50a), comprising: an aerostructure (60; 60a) comprising an outer shell having a first end and a closed end spaced from the first end along a first dimension, a first female receiver disposed within an interior of the outer shell and spaced from the outer shell, and a plurality of first supports extending between the outer shell and an outer perimeter of the first female receiver, wherein the aerostructure (60; 60a) is an integral structure and comprises resin; a coupling assembly (100; 100a) comprising a coupling having a first coupling end and a second coupling end that are spaced along the first dimension and a first beam (120; 120a), the first beam (120; 120a) extending from the second coupling end in the first dimension, into the outer shell of the aerostructure (60; 60a), and into the first female receiver of the aerostructure (60; 60a); and at least one first fastener that extends through the outer shell and at least into the first beam (120; 120a). an aerostructure (60; 60a) comprising an outer shell having a first end and a closed end spaced from the first end along a first dimension, a first female receiver disposed within an interior of the outer shell and spaced from the outer shell, and a plurality of first supports extending between the outer shell and an outer perimeter of the first female receiver, wherein the aerostructure (60; 60a) is an integral structure and comprises resin; a coupling assembly (100; 100a) comprising a coupling having a first coupling end and a second coupling end that are spaced along the first dimension and a first beam (120; 120a), the first beam (120; 120a) extending from the second coupling end in the first dimension, into the outer shell of the aerostructure (60; 60a), and into the first female receiver of the aerostructure (60; 60a); and at least one first fastener that extends through the outer shell and at least into the first beam (120; 120a).
A method of debugging a processor, the method comprising: receiving an input of a template file for each of a plurality of test types; for each particular test type from the plurality of test types: generating a first predetermined number of randomized subtests according to a respective template file of the particular test type, and compiling the first predetermined number of randomized subtests into a test binary for the particular test type; linking the test binary for each of plurality of test types to form a test library; randomly selecting a subset of test binaries from the test library; executing each of the selected subset of test binaries on a number of physical threads of the processor according to a control data structure for each test binary, wherein the executing includes randomly selecting particular randomized subtests from each test binary of the subset of test binaries and running each of the selected particular randomized subtests; detecting one or more errors in the executing; and redesigning the processor based on the one or more errors detected. receiving an input of a template file for each of a plurality of test types; for each particular test type from the plurality of test types: generating a first predetermined number of randomized subtests according to a respective template file of the particular test type, and compiling the first predetermined number of randomized subtests into a test binary for the particular test type; generating a first predetermined number of randomized subtests according to a respective template file of the particular test type, and compiling the first predetermined number of randomized subtests into a test binary for the particular test type; linking the test binary for each of plurality of test types to form a test library; randomly selecting a subset of test binaries from the test library; executing each of the selected subset of test binaries on a number of physical threads of the processor according to a control data structure for each test binary, wherein the executing includes randomly selecting particular randomized subtests from each test binary of the subset of test binaries and running each of the selected particular randomized subtests; detecting one or more errors in the executing; and redesigning the processor based on the one or more errors detected.
A compound for use in preventing or treating cancer cachexia in a subject, wherein the compound is of general formula I: or a pharmaceutically acceptable salt or solvate thereof; wherein - R 1 is a C 1 -C 6 alkyl group, which alkyl group carries up to five -OR 2 substituents, wherein R 2 represents hydrogen, or C 1 -C 6 alkyl or wherein -OR 2 represents a -3-hydroxybutyrate moiety; or - R 1 is a moiety derived from an alcohol HOR 1, wherein said alcohol is a sugar. - R 1 is a C 1 -C 6 alkyl group, which alkyl group carries up to five -OR 2 substituents, wherein R 2 represents hydrogen, or C 1 -C 6 alkyl or wherein -OR 2 represents a -3-hydroxybutyrate moiety; or - R 1 is a moiety derived from an alcohol HOR 1, wherein said alcohol is a sugar.
Method for controlling an illumination arrangement, in particular an illumination arrangement for illuminating a merchandise presentation surface, comprising the following steps: - providing the lighting arrangement; - providing a pattern; and characterized by the following steps: - providing a measuring arrangement for measuring color changes of the pattern due to the effects of light through the illumination arrangement in the region to be illuminated by the illumination arrangement, comprising a sensor arrangement which is suitable for determining a color change of the pattern; - arranging the pattern so that the pattern is exposed to the light of the illumination arrangement; - determining the color change of the pattern through the sensor arrangement after the pattern has been exposed to the light of the illumination arrangement for a predetermined duration; - controlling the illumination arrangement as a function of the color variation of the pattern determined by the measuring arrangement. - providing the lighting arrangement; - providing a pattern; - providing a measuring arrangement for measuring color changes of the pattern due to the effects of light through the illumination arrangement in the region to be illuminated by the illumination arrangement, comprising a sensor arrangement which is suitable for determining a color change of the pattern; - arranging the pattern so that the pattern is exposed to the light of the illumination arrangement; - determining the color change of the pattern through the sensor arrangement after the pattern has been exposed to the light of the illumination arrangement for a predetermined duration; - controlling the illumination arrangement as a function of the color variation of the pattern determined by the measuring arrangement.
A computer implemented method for analyzing a biological sample of a female pregnant with a plurality of fetuses to determine whether at least two fetuses of the pregnant female are dizygotic, the biological sample comprising fetal and maternal DNA, the method comprising: for each of a plurality of chromosomal regions: at each of one or more loci in the respective chromosomal region: measuring one or more alleles in the biological sample; and determining a respective amount of each measured allele; based on the respective amounts of the measured alleles, determining whether at least two of the fetuses have inherited a different haplotype of the respective chromosomal region from a first parent; determining a first amount of the chromosomal regions where at least two of the fetuses have inherited a different haplotype from the first parent; and comparing the first amount to a cutoff value to determine whether at least two of the fetuses are dizygotic. for each of a plurality of chromosomal regions: at each of one or more loci in the respective chromosomal region: measuring one or more alleles in the biological sample; and determining a respective amount of each measured allele; based on the respective amounts of the measured alleles, determining whether at least two of the fetuses have inherited a different haplotype of the respective chromosomal region from a first parent; at each of one or more loci in the respective chromosomal region: measuring one or more alleles in the biological sample; and determining a respective amount of each measured allele; measuring one or more alleles in the biological sample; and determining a respective amount of each measured allele; based on the respective amounts of the measured alleles, determining whether at least two of the fetuses have inherited a different haplotype of the respective chromosomal region from a first parent; determining a first amount of the chromosomal regions where at least two of the fetuses have inherited a different haplotype from the first parent; and comparing the first amount to a cutoff value to determine whether at least two of the fetuses are dizygotic.
A method of operating a smelt cyclone to control accretions of metalliferous feed material at the inside of the smelt cyclone, wherein the smelt cyclone is provided with an array of tuyeres (22,24,26,28) to supply feed material and an oxygen containing gas into the smelt cyclone and wherein a cooling system with fluid-cooled panels is provided in the wall of the smelt cyclone, characterized in that the method comprises controlling the supply of feed material and/or oxygen containing gas dependent on temperatures measured in the fluid-cooled panels, wherein changes in the measured temperatures are used to determine changes in heat flux, and wherein the supply of metalliferous feed material is reduced to below normal-operation supply rates through tuyeres used to inject metalliferous feed material to the smelt cyclone which are directed at areas with temperatures or heat fluxes that are below the temperatures or heat fluxes measured during normal-operation.
A method for preparing fluorine-containing vinyl ether, comprising carrying out - hydrolytic neutralization on a small molecular weight byproduct which is produced in the process of preparing perfluoropolyether or a perfluorinated surfactant by photooxidation of fluorine-containing olefin; and - obtaining fluorine-containing vinyl ether by drying and cracking. - hydrolytic neutralization on a small molecular weight byproduct which is produced in the process of preparing perfluoropolyether or a perfluorinated surfactant by photooxidation of fluorine-containing olefin; and - obtaining fluorine-containing vinyl ether by drying and cracking.
A display device comprising: a flexible display layer, the flexible display layer comprising: a display area comprising: an upper flat area extending along a first plane; lower display areas extending along a second plane, which is parallel to the first plane and separated from the first plane by a distance (d e); and bent side display areas connecting the upper flat area and the lower display areas; and non-display areas extending from at least one edge of the lower display areas at a location where the lower display areas meet, wherein the non-display areas are bent to extend towards the first plane, and configured to receive a signal for displaying an image on the flexible display layer, wherein the display area extends across an entire upper surface, lateral sides, and the bottom surface of the display device. an upper flat area extending along a first plane; lower display areas extending along a second plane, which is parallel to the first plane and separated from the first plane by a distance (d e); and bent side display areas connecting the upper flat area and the lower display areas; and non-display areas extending from at least one edge of the lower display areas at a location where the lower display areas meet, wherein the non-display areas are bent to extend towards the first plane, and configured to receive a signal for displaying an image on the flexible display layer, wherein the display area extends across an entire upper surface, lateral sides, and the bottom surface of the display device.