A prosthetic valve for implanting in a native valve of a patient, said prosthetic valve comprising: a self-expanding frame having a first end, a second end opposite the first end, an atrial region near the second end, a ventricular region near the first end, an anterior portion, and a posterior portion, wherein the self-expanding frame has an expanded configuration and a collapsed configuration, the expanded configuration adapted to engage tissue at a treatment site, and the collapsed configuration adapted to be delivered to the treatment site, and wherein the expandable frame comprises: a self-expanding atrial skirt disposed in the atrial region; a self-expanding ventricular skirt disposed in the ventricular region; a self-expanding annular region disposed between the atrial region and the ventricular region; a first self-expanding anterior tab disposed on the anterior portion of the self-expanding frame in the ventricular region; and a self-expanding foot coupled to the ventricular region, wherein the foot is disposed in the posterior portion and extends radially outward at least 10mm from the self-expanding frame and has an outer surface for engaging the tissue, thereby facilitating anchoring of the prosthetic valve and minimizing or preventing rotation of the prosthetic valve. a self-expanding frame having a first end, a second end opposite the first end, an atrial region near the second end, a ventricular region near the first end, an anterior portion, and a posterior portion, wherein the self-expanding frame has an expanded configuration and a collapsed configuration, the expanded configuration adapted to engage tissue at a treatment site, and the collapsed configuration adapted to be delivered to the treatment site, and wherein the expandable frame comprises: a self-expanding atrial skirt disposed in the atrial region; a self-expanding ventricular skirt disposed in the ventricular region; a self-expanding annular region disposed between the atrial region and the ventricular region; a first self-expanding anterior tab disposed on the anterior portion of the self-expanding frame in the ventricular region; and a self-expanding foot coupled to the ventricular region, wherein the foot is disposed in the posterior portion and extends radially outward at least 10mm from the self-expanding frame and has an outer surface for engaging the tissue, thereby facilitating anchoring of the prosthetic valve and minimizing or preventing rotation of the prosthetic valve. a self-expanding atrial skirt disposed in the atrial region; a self-expanding ventricular skirt disposed in the ventricular region; a self-expanding annular region disposed between the atrial region and the ventricular region; a first self-expanding anterior tab disposed on the anterior portion of the self-expanding frame in the ventricular region; and a self-expanding foot coupled to the ventricular region, wherein the foot is disposed in the posterior portion and extends radially outward at least 10mm from the self-expanding frame and has an outer surface for engaging the tissue, thereby facilitating anchoring of the prosthetic valve and minimizing or preventing rotation of the prosthetic valve.