A device, comprising: - an extraction chamber filled with an extraction reagent, wherein the extraction reagent includes a nitrite salt, - a swab comprising a tip and a stem, the tip being an absorptive component attached to the stem that is configured to incorporate a non-volatile reagent on a back end at a tip-stem boundary, away from a sample collection zone of the of the absorptive component, and to collect a biological sample at the sample collection zone, wherein the absorptive component comprises the non-volatile reagent, wherein the non-volatile reagent is configured to react with the extraction reagent to form an extraction solution, the extraction solution configured to extract an analyte from the biological sample, wherein the non-volatile reagent is acidic, wherein the swab is configured to be received within the extraction chamber so as to position the absorptive component of the swab in fluid communication with the extraction reagent so as to form the extraction solution, - a test strip configured to be brought in fluid communication with the extraction solution following extraction of the analyte from the biological sample, the test strip comprising: - a sample receiving portion configured to accept a sample, wherein the sample is a liquid sample, and wherein the sample receiving portion is configured to permit the movement of the analyte in the liquid sample through the test strip by capillary action, - a site on the strip where an analyte-specific labeled reagent has been incorporated, wherein the analyte-specific labeled reagent is configured to bind the analyte from the biological sample, and wherein the analyte-specific labeled reagent comprises a molecule that is configured to bind the analyte specifically and with high affinity and wherein the analyte-specific labeled reagent is labeled with a label that allows its detection, - a capture portion configured to receive the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and - an adsorbent pad attached to a distal end of the test strip and configured to bind to an excess extraction reagent thereby allowing flow across the test strip. - an extraction chamber filled with an extraction reagent, wherein the extraction reagent includes a nitrite salt, - a swab comprising a tip and a stem, the tip being an absorptive component attached to the stem that is configured to incorporate a non-volatile reagent on a back end at a tip-stem boundary, away from a sample collection zone of the of the absorptive component, and to collect a biological sample at the sample collection zone, wherein the absorptive component comprises the non-volatile reagent, wherein the non-volatile reagent is configured to react with the extraction reagent to form an extraction solution, the extraction solution configured to extract an analyte from the biological sample, wherein the non-volatile reagent is acidic, wherein the swab is configured to be received within the extraction chamber so as to position the absorptive component of the swab in fluid communication with the extraction reagent so as to form the extraction solution, - a test strip configured to be brought in fluid communication with the extraction solution following extraction of the analyte from the biological sample, the test strip comprising: - a sample receiving portion configured to accept a sample, wherein the sample is a liquid sample, and wherein the sample receiving portion is configured to permit the movement of the analyte in the liquid sample through the test strip by capillary action, - a site on the strip where an analyte-specific labeled reagent has been incorporated, wherein the analyte-specific labeled reagent is configured to bind the analyte from the biological sample, and wherein the analyte-specific labeled reagent comprises a molecule that is configured to bind the analyte specifically and with high affinity and wherein the analyte-specific labeled reagent is labeled with a label that allows its detection, - a capture portion configured to receive the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and - an adsorbent pad attached to a distal end of the test strip and configured to bind to an excess extraction reagent thereby allowing flow across the test strip. - a test strip configured to be brought in fluid communication with the extraction solution following extraction of the analyte from the biological sample, the test strip comprising: - a sample receiving portion configured to accept a sample, wherein the sample is a liquid sample, and wherein the sample receiving portion is configured to permit the movement of the analyte in the liquid sample through the test strip by capillary action, - a site on the strip where an analyte-specific labeled reagent has been incorporated, wherein the analyte-specific labeled reagent is configured to bind the analyte from the biological sample, and - a capture portion configured to receive the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and - an adsorbent pad attached to a distal end of the test strip and configured to bind to an excess extraction reagent thereby allowing flow across the test strip.