A nucleic acid sequencing method comprising: contacting a spatially defined, at a spatially defined site, target nucleic acid sequence with N≥1 oligonucleotide probes, i) if N=1, said oligonucleotide probe having a label; ii) if N ≥2, each oligonucleotide probe of said N oligonucleotide probes having a nucleic acid sequence that is different from nucleic acid sequences of the other N-1 oligonucleotide probes of said N oligonucleotide probes; and iiia) if N ≥2, said N oligonucleotide probes having different labels; or iiib) if N ≥2, an oligonucleotide probe of said N oligonucleotide probes lacking a label and the other N-1 oligonucleotide probes of said N oligonucleotide probes having different labels; performing measurements, at least at said spatially defined site, at M ≥2 time instances during i) a hybridization reaction comprising hybridization of said N oligonucleotide probes to said target nucleic acid sequence or ii) a ligation reaction comprising ligation of said N oligonucleotide probes to an anchor probe complementary to a segment of a nucleic acid molecule comprising said target nucleic acid sequence to form M data sets; co-processing said M data sets in order to identify a label or absence of any label at said spatially defined site; and determining a sequenced base of said target nucleic acid sequence based on said identified label or said identified absence of any label. contacting a spatially defined, at a spatially defined site, target nucleic acid sequence with N≥1 oligonucleotide probes, i) if N=1, said oligonucleotide probe having a label; ii) if N ≥2, each oligonucleotide probe of said N oligonucleotide probes having a nucleic acid sequence that is different from nucleic acid sequences of the other N-1 oligonucleotide probes of said N oligonucleotide probes; and iiia) if N ≥2, said N oligonucleotide probes having different labels; or iiib) if N ≥2, an oligonucleotide probe of said N oligonucleotide probes lacking a label and the other N-1 oligonucleotide probes of said N oligonucleotide probes having different labels; i) if N=1, said oligonucleotide probe having a label; ii) if N ≥2, each oligonucleotide probe of said N oligonucleotide probes having a nucleic acid sequence that is different from nucleic acid sequences of the other N-1 oligonucleotide probes of said N oligonucleotide probes; and iiia) if N ≥2, said N oligonucleotide probes having different labels; or iiib) if N ≥2, an oligonucleotide probe of said N oligonucleotide probes lacking a label and the other N-1 oligonucleotide probes of said N oligonucleotide probes having different labels; iiia) if N ≥2, said N oligonucleotide probes having different labels; or iiib) if N ≥2, an oligonucleotide probe of said N oligonucleotide probes lacking a label and the other N-1 oligonucleotide probes of said N oligonucleotide probes having different labels; performing measurements, at least at said spatially defined site, at M ≥2 time instances during i) a hybridization reaction comprising hybridization of said N oligonucleotide probes to said target nucleic acid sequence or ii) a ligation reaction comprising ligation of said N oligonucleotide probes to an anchor probe complementary to a segment of a nucleic acid molecule comprising said target nucleic acid sequence to form M data sets; co-processing said M data sets in order to identify a label or absence of any label at said spatially defined site; and determining a sequenced base of said target nucleic acid sequence based on said identified label or said identified absence of any label.