A hand-held device for delivery and removal of fluids comprising: (a) a removable and replaceable head comprising: (i) a housing, (ii) an irrigant reservoir within the housing, the irrigant reservoir adapted to contain irrigation fluid, (iii) an aspirant reservoir within the housing, the aspirant reservoir adapted to contain aspirated fluid, (iv) a barrier means adapted to retain aspirated liquid in the aspirant reservoir and allow gas to pass out of the aspirant reservoir, (v) at least one nozzle extending from the housing, the nozzle including an irrigant lumen adapted to provide fluid communication between the irrigant reservoir and an irrigant port, and an aspirant lumen adapted to provide fluid communication between the aspirant reservoir and an aspirant port; (b) a body adapted to be releasably coupled to the housing, the body including pumping means adapted to expel irrigation fluid from the irrigant reservoir through the irrigant port and pumping means to draw fluid into the aspirant reservoir through the aspirant port; (c) an interface region for coupling the head to the body, the interface region comprising at least one non-fluid flow component and at least one gas flow component, wherein the device is sized and configured to be portable and held for operation in a user's hand; characterized in that the removeable and replaceable head further comprises a diagnostic means embedded in one of: the head and the aspirant reservoir and configured for testing the aspirated liquid drawn into the aspirant reservoir, and in that the aspirant reservoir comprises a smaller sample collection chamber, a first portion of the diagnostic means extending into the smaller chamber and the remainder of the diagnostic means being sealed off and separated from the smaller chamber. (a) a removable and replaceable head comprising: (i) a housing, (ii) an irrigant reservoir within the housing, the irrigant reservoir adapted to contain irrigation fluid, (iii) an aspirant reservoir within the housing, the aspirant reservoir adapted to contain aspirated fluid, (iv) a barrier means adapted to retain aspirated liquid in the aspirant reservoir and allow gas to pass out of the aspirant reservoir, (v) at least one nozzle extending from the housing, the nozzle including an irrigant lumen adapted to provide fluid communication between the irrigant reservoir and an irrigant port, and an aspirant lumen adapted to provide fluid communication between the aspirant reservoir and an aspirant port; (i) a housing, (ii) an irrigant reservoir within the housing, the irrigant reservoir adapted to contain irrigation fluid, (iii) an aspirant reservoir within the housing, the aspirant reservoir adapted to contain aspirated fluid, (iv) a barrier means adapted to retain aspirated liquid in the aspirant reservoir and allow gas to pass out of the aspirant reservoir, (v) at least one nozzle extending from the housing, the nozzle including an irrigant lumen adapted to provide fluid communication between the irrigant reservoir and an irrigant port, and an aspirant lumen adapted to provide fluid communication between the aspirant reservoir and an aspirant port; (b) a body adapted to be releasably coupled to the housing, the body including pumping means adapted to expel irrigation fluid from the irrigant reservoir through the irrigant port and pumping means to draw fluid into the aspirant reservoir through the aspirant port; (c) an interface region for coupling the head to the body, the interface region comprising at least one non-fluid flow component and at least one gas flow component, wherein the device is sized and configured to be portable and held for operation in a user's hand;