Plasmapheresis device, with: a collection bag for receiving a predetermined amount of blood, a first flow path connected to the collection bag and supplying blood to the collection bag, a bag containing a citrate-phosphate-dextrose solution, a bag containing a saline solution, a hollow fiber filter for separating the blood into a concentrate of cellular components and plasma, a concentrate bag for receiving the concentrate of cellular constituents separated by the hollow fiber filter, a plasma bag for receiving the plasma separated by the hollow fiber filter, a second flow path connected to the bag containing the saline solution and adapted to be connected to a vein, a third flow path which connects the removal bag to the plasma bag via the hollow fiber filter and through which the plasma separated by the hollow fiber filter flows into the plasma bag, a fourth flow path connecting the collection bag and the concentrate bag via the hollow fiber filter and through which the cellular constituents concentrated by the hollow fiber filter flow into the concentrate bag, a fifth flow path connecting the concentrate bag directly to the collection bag and through which the cellular components concentrated by the hollow fiber filter flow from the concentrate bag back into the collection bag, a sixth flow path connected to the removal bag and adapted to be connected to a vein, and a seventh flow path connecting the bag containing the citrate-phosphate dextrose solution to the blood collection bag, wherein, for generating a hydrostatic pressure, the removal bag is arranged at a height above the hollow-fiber filter adapted to the pore size of the hollow-fiber filter, and wherein each flow path is formed as a hose portion having a clamp for selectively opening and closing the flow path. a collection bag for receiving a predetermined amount of blood, a first flow path connected to the collection bag and supplying blood to the collection bag, a bag containing a citrate-phosphate-dextrose solution, a bag containing a saline solution, a hollow fiber filter for separating the blood into a concentrate of cellular components and plasma, a concentrate bag for receiving the concentrate of cellular constituents separated by the hollow fiber filter, a plasma bag for receiving the plasma separated by the hollow fiber filter, a second flow path connected to the bag containing the saline solution and adapted to be connected to a vein, a third flow path which connects the removal bag to the plasma bag via the hollow fiber filter and through which the plasma separated by the hollow fiber filter flows into the plasma bag, a fourth flow path connecting the collection bag and the concentrate bag via the hollow fiber filter and through which the cellular constituents concentrated by the hollow fiber filter flow into the concentrate bag, a fifth flow path connecting the concentrate bag directly to the collection bag and through which the cellular components concentrated by the hollow fiber filter flow from the concentrate bag back into the collection bag, a sixth flow path connected to the removal bag and adapted to be connected to a vein, and a seventh flow path connecting the bag containing the citrate-phosphate dextrose solution to the blood collection bag, wherein, for generating a hydrostatic pressure, the removal bag is arranged at a height above the hollow-fiber filter adapted to the pore size of the hollow-fiber filter, and wherein each flow path is formed as a hose portion having a clamp for selectively opening and closing the flow path.