Device for extracting physiological information indicative of at least one vital sign of a subject, said device comprising: - a pre-treatment unit configured to derive at least three detection signals from electromagnetic radiation reflected from a skin region of a subject, wherein at least two detection signals comprise wavelength-dependent reflection information in a different wavelength channel and at least two detection signals comprise reflection information in different polarization channels having different polarization directions, wherein the pre-treatment unit is further configured to derive two of the at least three detection signals comprising wavelength-dependent reflection information in the same wavelength channel but in different polarization channels and/or to derive one of the at least three detection signals as a difference detection signal representing the difference between first reflection information in a first wavelength channel and a first polarization channel having a first polarization direction and second reflection information in the first wavelength channel and a second polarization channel having a second polarization direction different from the first polarization direction, - a pulse signal computation unit configured to compute at least two pulse signals from said at least three detection signals using different given signature vectors, wherein for the computation of each pulse signal a different given signature vector is used, wherein a given signature vector represents expected relative pulsatilities of the respective pulse signal in the at least three detection signals, wherein the computation of a pulse signal involves computing a weighted combination of the at least three detection signals using weights resulting in a pulse signal for which the products with the original detection signals equals the relative pulsatilities as represented by the respective signature vector, - a quality indicator computation unit configured to compute quality indicator values for said pulse signals indicating a characteristic of the respective pulse signal, and - a processing unit configured to derive physiological information indicative of at least one vital sign from the signature vector that results in the pulse signal with the best quality indicator value and/or from said pulse signal with the best quality indicator value itself. - a pre-treatment unit configured to derive at least three detection signals from electromagnetic radiation reflected from a skin region of a subject, wherein at least two detection signals comprise wavelength-dependent reflection information in a different wavelength channel and at least two detection signals comprise reflection information in different polarization channels having different polarization directions, wherein the pre-treatment unit is further configured to derive two of the at least three detection signals comprising wavelength-dependent reflection information in the same wavelength channel but in different polarization channels and/or to derive one of the at least three detection signals as a difference detection signal representing the difference between first reflection information in a first wavelength channel and a first polarization channel having a first polarization direction and second reflection information in the first wavelength channel and a second polarization channel having a second polarization direction different from the first polarization direction, - a pulse signal computation unit configured to compute at least two pulse signals from said at least three detection signals using different given signature vectors, wherein for the computation of each pulse signal a different given signature vector is used, wherein a given signature vector represents expected relative pulsatilities of the respective pulse signal in the at least three detection signals, wherein the computation of a pulse signal involves computing a weighted combination of the at least three detection signals using weights resulting in a pulse signal for which the products with the original detection signals equals the relative pulsatilities as represented by the respective signature vector, - a quality indicator computation unit configured to compute quality indicator values for said pulse signals indicating a characteristic of the respective pulse signal, and - a processing unit configured to derive physiological information indicative of at least one vital sign from the signature vector that results in the pulse signal with the best quality indicator value and/or from said pulse signal with the best quality indicator value itself.