mhurhangee/ep-ind-claims huggingface dataset:
A compound represented by Formula I: or a stereoisomer, tautomer, or salt thereof, wherein: R 1 is L 1 -X; R 2 is halogen or SO 2 NH 2; R 3 is H or halogen; R 4, R 7, R 8, and R 11 when taken alone are independently H, halogen, or optionally substituted C 1 -C 6 alkyl; R 5, R 6, R 9, and R 10 when taken alone are independently H or optionally substituted C 1 -C 6 alkyl; R 4 and R 5 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 4 and R 5 are attached; R 6 and R 7 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 6 and R 7 are attached; R 8 and R 9 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 8 and R 9 are attached; R 10 and R 11 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 10 and R 11 are attached; R 5 and R 6, when taken together with the nitrogen atom to which R 5 and R 6 are attached, form a 5-membered or a 6-membered unsaturated ring; R 9 and R 10, when taken together with the nitrogen atom to which R 9 and R 10 are attached, form a 5-membered or a 6-membered unsaturated ring; L 1 is an optionally substituted C 2 -C 10 alkylene or optionally substituted C 2 -C 20 heteroalkylene; Xis and wherein the term "alkyl" includes a straight-chain, branched-chain, or cyclic monovalent hydrocarbyl radical, or a combination thereof, which contain(s) only C and H when unsubstituted, and wherein the alkyl is optionally substituted. R 1 is L 1 -X; R 2 is halogen or SO 2 NH 2; R 3 is H or halogen; R 4, R 7, R 8, and R 11 when taken alone are independently H, halogen, or optionally substituted C 1 -C 6 alkyl; R 5, R 6, R 9, and R 10 when taken alone are independently H or optionally substituted C 1 -C 6 alkyl; R 4 and R 5 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 4 and R 5 are attached; R 6 and R 7 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 6 and R 7 are attached; R 8 and R 9 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 8 and R 9 are attached; R 10 and R 11 when taken together are an optionally substituted C 2 -C 3 alkylene chain connecting the atoms to which R 10 and R 11 are attached; R 5 and R 6, when taken together with the nitrogen atom to which R 5 and R 6 are attached, form a 5-membered or a 6-membered unsaturated ring; R 9 and R 10, when taken together with the nitrogen atom to which R 9 and R 10 are attached, form a 5-membered or a 6-membered unsaturated ring; L 1 is an optionally substituted C 2 -C 10 alkylene or optionally substituted C 2 -C 20 heteroalkylene; Xis and wherein the term "alkyl" includes a straight-chain, branched-chain, or cyclic monovalent hydrocarbyl radical, or a combination thereof, which contain(s) only C and H when unsubstituted, and wherein the alkyl is optionally substituted.
A terminal comprising: a transmitting/receiving section adapted to receive a configuration indicating indexes respectively corresponding to sets of cyclic shift candidates; and a control section adapted to determine a cyclic shift of a set of cyclic shift candidates, the set of cyclic shift candidates corresponding to an index of the indexes, and generate a sequence using the cyclic shift, wherein the transmitting/receiving section is further adapted to transmit the sequence in a physical uplink control channel, wherein the cyclic shift corresponds to an uplink control information value, wherein when the uplink control information value is one of two values of a 1-bit Hybrid Automatic Repeat reQuest-Acknowledgement, HARQ-ACK, an interval between two cyclic shifts of the set of cyclic shift candidates respectively corresponding to the two values is equal to π, and when the uplink control information value is one of four values of a 2-bit HARQ-ACK, intervals between four cyclic shifts of the set of cyclic shift candidates respectively corresponding to the four values are each equal to π/2, and wherein the index is based on the remainder obtained from division of a value based on a Control Channel Element, CCE, index of a physical downlink control channel by the number of the indexes. a transmitting/receiving section adapted to receive a configuration indicating indexes respectively corresponding to sets of cyclic shift candidates; and a control section adapted to determine a cyclic shift of a set of cyclic shift candidates, the set of cyclic shift candidates corresponding to an index of the indexes, and generate a sequence using the cyclic shift, wherein the transmitting/receiving section is further adapted to transmit the sequence in a physical uplink control channel, wherein the cyclic shift corresponds to an uplink control information value, wherein when the uplink control information value is one of two values of a 1-bit Hybrid Automatic Repeat reQuest-Acknowledgement, HARQ-ACK, an interval between two cyclic shifts of the set of cyclic shift candidates respectively corresponding to the two values is equal to π, and when the uplink control information value is one of four values of a 2-bit HARQ-ACK, intervals between four cyclic shifts of the set of cyclic shift candidates respectively corresponding to the four values are each equal to π/2, and wherein the index is based on the remainder obtained from division of a value based on a Control Channel Element, CCE, index of a physical downlink control channel by the number of the indexes.
A wavefront analysis system for measuring aberrations in an eye, comprising: a projecting optical system (12,14,16,18) producing light to be delivered onto a retina of an eye; an adjustable telescope which compensates the light to be delivered onto the retina of the eye for refractive errors in the eye, the adjustable telescope being positioned in an optical path between the projecting optical system and the eye and having lenses (32, 34) that are moveable relative to one another to correct for defocus aberrations of the eye; an imaging system which collects light scattered by the retina; and a wavefront sensor receiving light returned by the retina from the imaging system and detecting an amplitude and phase of a wavefront of the received light, the telescope further comprising a dynamic range limiting aperture that blocks any rays of the light returned by the retina outside an angular dynamic range of the wavefront sensor, the aperture being positioned in between the lenses (32, 34), and wherein the adjustable telescope is located in an optical path from the eye to the wavefront sensor. a projecting optical system (12,14,16,18) producing light to be delivered onto a retina of an eye; an adjustable telescope which compensates the light to be delivered onto the retina of the eye for refractive errors in the eye, the adjustable telescope being positioned in an optical path between the projecting optical system and the eye and having lenses (32, 34) that are moveable relative to one another to correct for defocus aberrations of the eye; an imaging system which collects light scattered by the retina; and a wavefront sensor receiving light returned by the retina from the imaging system and detecting an amplitude and phase of a wavefront of the received light, the telescope further comprising a dynamic range limiting aperture that blocks any rays of the light returned by the retina outside an angular dynamic range of the wavefront sensor, the aperture being positioned in between the lenses (32, 34), and wherein the adjustable telescope is located in an optical path from the eye to the wavefront sensor.
A refiner segment arrangeable on a refiner element (2; 3) in a disc refiner intended for refining fibrous material, the refiner segment having a radially inner edge and a radially outer edge and comprising refining zones (Z(x)) where refining of the fibrous material takes place, the refiner segment being provided with a pattern of bars arranged at a respective feeding angle (β (x)) relative to a radius of the refiner segment within a respective refining zone (Z(x)), the feeding angle (β (x)) being directed opposite to a first circumferential direction on the refiner segment, and intermediate grooves between the bars, and dams extending between the bars and protruding above the surface of the grooves, characterized in that the dams are arranged at least at the ends of at least some of the bars at borders between the refining zones (Z(x)) such that openings are formed at the radially inner ends of the bars at the borders between the refining zones (Z(x)), radially outside of the dams with respect to the radially inner edge of the refiner segment, the openings being configured to allow back-streaming steam to flow along the bars and dams and pass through the openings towards the inner edge of the refiner segment, the lengths of the bars within a refining zone (Z(x)) increasing in a direction opposite to the first circumferential direction and being adapted such that a respective angle (γ (x)) is formed between an imaginary line connecting the openings at a radially inner border of a respective refining zone (Z(x)), and a line which is perpendicular to a radius (r) of the refiner segment.
A guidewire delivery catheter used to implant a shunt between the coronary sinus and the left atrium, the catheter comprising: a needle housed within the catheter in a delivery configuration, the needle configured to extend out of the catheter to puncture a vessel wall in a deployment configuration; a needle port through which the needle extends out of the catheter to transition from the delivery configuration to the deployment configuration; characterised by a securing mechanism housed within the catheter in a delivery configuration, the securing mechanism comprising a compliant wire configured to be advanced out of the catheter in a deployment configuration; and a wire port through which the compliant wire of the securing mechanism extends out of the catheter to transition from the delivery configuration to the deployment configuration, wherein the compliant wire includes a curved endcap at a distal end of the compliant wire so that the curved endcap of the compliant wire comes into contact with the vessel wall to provide wall apposition for the needle to puncture the vessel wall. a needle housed within the catheter in a delivery configuration, the needle configured to extend out of the catheter to puncture a vessel wall in a deployment configuration; a needle port through which the needle extends out of the catheter to transition from the delivery configuration to the deployment configuration; characterised by a securing mechanism housed within the catheter in a delivery configuration, the securing mechanism comprising a compliant wire configured to be advanced out of the catheter in a deployment configuration; and a wire port through which the compliant wire of the securing mechanism extends out of the catheter to transition from the delivery configuration to the deployment configuration, wherein the compliant wire includes a curved endcap at a distal end of the compliant wire so that the curved endcap of the compliant wire comes into contact with the vessel wall to provide wall apposition for the needle to puncture the vessel wall.
A compound comprising a Transient Receptor Potential Vanilloid 6 (TRPV6)-binding peptide conjugated to a biomolecule, wherein the TRPV6-binding peptide does not exhibit paralytic activity and: a) comprises from 9 to 27 contiguous amino acids of the C-terminal sequence of SEQ ID NO:1; b) has at least 70% identity to the amino acid sequence HPSKVDLPR; c) has at least 70% identity to the amino acid sequence KEFLHPSKVDLPR; or d) has at least 70% identity to the amino acid sequence EGKLSSNDTEGGLCKEFLHPSKVDLPR. a) comprises from 9 to 27 contiguous amino acids of the C-terminal sequence of SEQ ID NO:1; b) has at least 70% identity to the amino acid sequence HPSKVDLPR; c) has at least 70% identity to the amino acid sequence KEFLHPSKVDLPR; or d) has at least 70% identity to the amino acid sequence EGKLSSNDTEGGLCKEFLHPSKVDLPR.
A system for providing one or both of light and ultrasound to a skin surface, comprising: a flexible device having a layered structure and comprising a flexible substrate that supports (a) a flexible light emitter layer comprising a plurality of printed light emitting diodes, wherein the flexible light emitter layer is electrically coupled to a first flexible conductive layer and a second flexible conductive layer, wherein at least one of the first and second flexible conductive layers is transparent, wherein the flexible light emitter layer is configured to emit light with an intensity that is substantially constant across a surface of the device when driven by a first power source connected to the first and second flexible conductive layers so as to provide a substantially uniform light emission; and (b) a flexible ultrasound emitter layer comprising a piezoelectric coating, wherein the flexible ultrasound emitter layer is electrically coupled to a third flexible conductive layer and a fourth flexible conductive layer, wherein the flexible ultrasound emitter layer is configured to emit ultrasound with an intensity that is substantially constant across the surface of the device when driven by a second power source connected to the third and fourth flexible conductive layers so as to provide a substantially uniform ultrasound field.
A recombinant microorganism for producing 2,3-butanediol and 1,3-propanediol, wherein a pathway for converting pyruvate to lactate and a pathway for converting oxaloacetate to succinate are inhibited in a microorganism having a diol biosynthetic pathway wherein the microorganism is Klebsiella and the recombinant microorganism has decreased succinate-producing ability in comparison to a wild type microorganism.
A modified resin for a molded article obtained by modifying an ethylene/unsaturated carboxylic acid copolymer with at least one guanidine compound selected from guanidine derivatives and salts thereof, wherein a melt flow rate of the ethylene/unsaturated carboxylic acid copolymer, measured according to the Japanese Industrial Standard: JIS K7210 at a temperature of 190 °C and a loaded weight of 2160 g, is 20 (g/10 minutes) or more and 600 (g/10 minutes) or less.
A catheter comprising: an elongated catheter body having proximal and distal ends and at least one lumen therethrough; a basket-shaped electrode assembly at the distal end of the catheter body, the basket-shaped electrode assembly having proximal and distal ends and comprising a plurality of spines, at least one spine having at least one region of greater flexibility between at least two regions of lesser flexibility, wherein the assembly is adapted to assume a collapsed configuration, wherein the at least one spine is arranged along the axis of the catheter body, and an expanded configuration, wherein the at least one spine has a generally uniform flexed curvature along its length, an expander configured to move longitudinally relative to the catheter to change the assembly from the collapsed configuration to the expanded configuration, wherein the assembly is also adapted to assume a hyper-expanded configuration having a generally uniform curvature at the at least two regions of lesser flexibility and at the at least one region of greater flexibility a hyper or more acute curvature, wherein the at least one region of greater flexibility in the at least one spine allows the spine to change elastically between the expanded configuration and the hyper-expanded configuration in response to an additional force when the assembly, including its distal end, contacts tissue, and wherein the catheter further comprises a tensile member affixed to and connecting adjacent spines to each other. an elongated catheter body having proximal and distal ends and at least one lumen therethrough; a basket-shaped electrode assembly at the distal end of the catheter body, the basket-shaped electrode assembly having proximal and distal ends and comprising a plurality of spines, at least one spine having at least one region of greater flexibility between at least two regions of lesser flexibility, wherein the assembly is adapted to assume a collapsed configuration, wherein the at least one spine is arranged along the axis of the catheter body, and an expanded configuration, wherein the at least one spine has a generally uniform flexed curvature along its length, an expander configured to move longitudinally relative to the catheter to change the assembly from the collapsed configuration to the expanded configuration, wherein the assembly is also adapted to assume a hyper-expanded configuration having a generally uniform curvature at the at least two regions of lesser flexibility and at the at least one region of greater flexibility a hyper or more acute curvature, wherein the at least one region of greater flexibility in the at least one spine allows the spine to change elastically between the expanded configuration and the hyper-expanded configuration in response to an additional force when the assembly, including its distal end, contacts tissue, and wherein the catheter further comprises a tensile member affixed to and connecting adjacent spines to each other.
A process for the production of extracts from branches of Sambucus nigra L. comprises the following procedures a. arrangement of two-year-old branches of Sambucus nigra L. b. addition of deionized water and extraction of the material obtained from the procedure a) in an autoclave at pressure between 2 and 5 atm and in the absence of air, for times varying from 1 to 5 hours and at a temperature of 120 - 150°C, using a weight ratio of material obtained from stage a): deionized water from 1:10 to 1:20; c. cooling to room temperature for a period of 5 - 24 hours and collection of the aqueous extract; d. filtration on a filter having a porosity such as to prevent the passage of sediment from 1 micron to 10 micron and obtainment of a filtered extract. a. arrangement of two-year-old branches of Sambucus nigra L. b. addition of deionized water and extraction of the material obtained from the procedure a) in an autoclave at pressure between 2 and 5 atm and in the absence of air, for times varying from 1 to 5 hours and at a temperature of 120 - 150°C, using a weight ratio of material obtained from stage a): deionized water from 1:10 to 1:20; c. cooling to room temperature for a period of 5 - 24 hours and collection of the aqueous extract; d. filtration on a filter having a porosity such as to prevent the passage of sediment from 1 micron to 10 micron and obtainment of a filtered extract.
A sliding component (10, 101) that has an annular shape and is disposed in a place where relative rotation is performed in a rotary machine, so as to relatively rotate with a counterpart sliding component, comprising a plurality of dynamic pressure generating mechanisms (14, 141) provided in a sliding surface of the sliding component, each of the dynamic pressure generating mechanisms (14, 141) including a deep groove portion (15, 115) that communicates with a leakage side, and a plurality of shallow groove portions (9A, 9A', 109A, 109C) that is shallower than the deep groove portion (15, 115), the shallow groove portions (9A, 9A', 109A, 109C) communicating with the deep groove portion (15, 115) and being arranged in a circumferential direction in parallel relationship to each other, characterized in that each of the dynamic pressure generating mechanisms further includes sub-shallow groove portions (9B, 109B, 109D) that directly communicate with the leakage side, are arranged in the circumferential direction in parallel relationship to each other on the leakage side of the shallow groove portions (9A, 9A', 109A, 109C), and are independent of the shallow groove portions (9A, 9A', 109A, 109C), wherein the shallow groove portions (9A, 9A', 109A, 109C) extend from both sides of the deep groove portion (15, 115) in the circumferential direction. each of the dynamic pressure generating mechanisms further includes sub-shallow groove portions (9B, 109B, 109D) that directly communicate with the leakage side, are arranged in the circumferential direction in parallel relationship to each other on the leakage side of the shallow groove portions (9A, 9A', 109A, 109C), and are independent of the shallow groove portions (9A, 9A', 109A, 109C), wherein the shallow groove portions (9A, 9A', 109A, 109C) extend from both sides of the deep groove portion (15, 115) in the circumferential direction.
An organopolysiloxane emulsion composition for making release paper or release film, obtained by dispersing in water a mixture comprising the following components to: 100 parts by weight of an alkenyl group-containing diorganopolysiloxane having at least two alkenyl groups per molecule and having a viscosity at 25°C of not more than 1,000 Pa·s; an organohydrogenpolysiloxane having at least two Si-H groups per molecule and having a viscosity at 25°C of not more than 1 Pa·s, in an amount corresponding to a number of moles of Si-H groups that is from 0.5 to 10 times the number of moles of alkenyl groups in component; from 0.01 to 3 parts by weight of a curing catalyst; and from 0.01 to 10 parts by weight of a polyether-modified and/or polyol-modified organosilicon compound, where viscosity is determined in accordance with the method outlined in the description. 100 parts by weight of an alkenyl group-containing diorganopolysiloxane having at least two alkenyl groups per molecule and having a viscosity at 25°C of not more than 1,000 Pa·s; an organohydrogenpolysiloxane having at least two Si-H groups per molecule and having a viscosity at 25°C of not more than 1 Pa·s, in an amount corresponding to a number of moles of Si-H groups that is from 0.5 to 10 times the number of moles of alkenyl groups in component; from 0.01 to 3 parts by weight of a curing catalyst; and from 0.01 to 10 parts by weight of a polyether-modified and/or polyol-modified organosilicon compound,
A unitary catheter placement device including: a non-threaded, laterally extending location portion for locating the device relative to a patient's head, and a tubular upstand extending upwardly from the location portion and having a bore therethrough, the bore being oriented such that the bore extends angularly relative to the patient's head in use; wherein the location portion includes a foot portion, one or more gripping configurations extending from an underside of the foot portion for pressing against a surface of the patient's head, and a tubular collar extending from a lower surface of the foot portion and, when in use, at least below an upper surface of the patient's head, the tubular collar being coaxial with the bore through the upstand; and wherein the bore includes an unbroken periphery. a non-threaded, laterally extending location portion for locating the device relative to a patient's head, and a tubular upstand extending upwardly from the location portion and having a bore therethrough, the bore being oriented such that the bore extends angularly relative to the patient's head in use; wherein the location portion includes a foot portion, one or more gripping configurations extending from an underside of the foot portion for pressing against a surface of the patient's head, and a tubular collar extending from a lower surface of the foot portion and, when in use, at least below an upper surface of the patient's head, the tubular collar being coaxial with the bore through the upstand; and wherein the bore includes an unbroken periphery.
An agent comprising a p62/SQSTM1 nucleic acid that encodes a polypeptide at least 98% identical to SEQ ID NO: 2; for use in treating, alleviating, ameliorating, relieving, delaying onset of, inhibiting progression of, reducing severity of, and/or reducing incidence of one or more symptoms of a non-cancer-related chronic inflammatory disease in a subject, wherein said agent inhibits the expression of a proinflammatory cytokine in a subject.