A method of acclimating a patient to a therapy, executed by a controller, the method comprising: providing an initial step of a therapy set up program as video and/or sound instruction via a user interface for the patient to perform; determining, via a biosensor positioned on the patient P, a patient's sympathetic activation; determining a stress level of the patient while performing the initial step and a task completion time needed to complete the initial step; determining a technical capability of the patient based on the task completion time; determining a readiness of the patient based on the sympathetic activation; determining a subsequent step of the therapy set up program for the patient to perform after the initial step based on a total step difficulty, wherein the total step difficulty is a sum of a technical difficulty and an emotional difficulty, wherein the technical difficulty is specified by an average time taken until completion and the amount of errors/retries before success across a patient population, wherein the emotional difficulty is specified by the average measured sympathetic activation during this step across the patient population; and providing the subsequent step as video and/or sound instruction via the user interface for the patient to perform, wherein the subsequent step has a technical difficulty smaller than the technical capability, and has an emotional difficulty smaller than the readiness, wherein the therapy is a positive airway pressure therapy. providing an initial step of a therapy set up program as video and/or sound instruction via a user interface for the patient to perform; determining, via a biosensor positioned on the patient P, a patient's sympathetic activation; determining a stress level of the patient while performing the initial step and a task completion time needed to complete the initial step; determining a technical capability of the patient based on the task completion time; determining a readiness of the patient based on the sympathetic activation; determining a subsequent step of the therapy set up program for the patient to perform after the initial step based on a total step difficulty, wherein the total step difficulty is a sum of a technical difficulty and an emotional difficulty, wherein the technical difficulty is specified by an average time taken until completion and the amount of errors/retries before success across a patient population, wherein the emotional difficulty is specified by the average measured sympathetic activation during this step across the patient population; and wherein the total step difficulty is a sum of a technical difficulty and an emotional difficulty, wherein the technical difficulty is specified by an average time taken until completion and the amount of errors/retries before success across a patient population, wherein the emotional difficulty is specified by the average measured sympathetic activation during this step across the patient population; and providing the subsequent step as video and/or sound instruction via the user interface for the patient to perform, wherein the subsequent step has a technical difficulty smaller than the technical capability, and has an emotional difficulty smaller than the readiness, wherein the therapy is a positive airway pressure therapy.