A substituted azole derivative represented by the following Formula or pharmaceutically acceptable salts thereof: wherein, R is selected from the group consisting of C 7 -C 15 arylalkyl unsubstituted or substituted by at least one selected from the group consisting of halogen, trifluoromethyl, trifluoroalkoxy, -NO 2, C(=O)OCH 3, linear or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy, benzyloxy,-C(=O)H, -OH and -CH=N-OH; C 4 -C 15 heteroarylalkyl unsubstituted or substituted by at least one selected from the group consisting of halogen, C(=O)OCH 3, linear or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy and benzyloxy; linear, branched, or cyclic C 1 -C 10 alkyl substituted by at least one selected from the group consisting of C 1 -C 3 alkyloxy, C 1 -C 3 alkylthio, carbamate, (-OC(=O)NH 2), tert-butyl-OC(=O)NH-, -NH 3 +, -NH 2, -OH, -C(=O)OCH 2 CH 3, NHC(=O)NH 2, trifluoromethylsufanyl, trifluoromethyl, and -CN, Y is selected from the group consisting of O and -N-R 1; R 1 is selected from the group consisting of H and linear or branched C 1 -C 3 alkyl; R 2 is selected from the group consisting of H and halogen; A is selected from the group consisting of O and S; B is selected from the group consisting of C and N; Z is selected from the group consisting of imidazole, pyrrolidine, and tetrazole unsubstituted or substituted by at least one substituent selected from the group consisting of OH, carbamate, linear or branched C 1 -C 4 alkyl, halogen, -NO 2, -NH 2,-CF 3, -CN and phenyl; -OC(=O)NR 3 R 4; NR 5 R 6; NHC(=NH)NH 2, and -NHC(=O)NH 2; each of R 3 and R 4 is independently selected from the group consisting of H; C 1 -C 5 alkyl unsubstituted or substituted by at least one selected from the group consisting of NH 2, and NR 7 R 8; piperidine, piperazine, and diazepane unsubstituted or substituted by C 1 -C 3 alkyl; or R 3 and R 4 together may form piperidine, piperazine, imidazole, pyrrolidine, triazole, tetrazole, diazepane or morpholine unsubstituted or substituted by C 1 -C 3 alkyl; each of R 5 and R 6 is independently selected from the group consisting of C 2 -C 3 alkene; C 2 -C 3 alkyne; and linear or branched C 1 -C 4 alkyl substituted by at least one selected from the group consisting of -OH, -C NH 2, C 1 -C 3 alkoxy, and carbamate; each of R 7 and R 8 is at least one independently selected from the group consisting of H and linear or branched C 1 -C 3 alkyl, each of m and n is independently 0 or 1. R is selected from the group consisting of C 7 -C 15 arylalkyl unsubstituted or substituted by at least one selected from the group consisting of halogen, trifluoromethyl, trifluoroalkoxy, -NO 2, C(=O)OCH 3, linear or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy, benzyloxy,-C(=O)H, -OH and -CH=N-OH; C 4 -C 15 heteroarylalkyl unsubstituted or substituted by at least one selected from the group consisting of halogen, C(=O)OCH 3, linear or branched C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl, phenyloxy and benzyloxy; linear, branched, or cyclic C 1 -C 10 alkyl substituted by at least one selected from the group consisting of C 1 -C 3 alkyloxy, C 1 -C 3 alkylthio, carbamate, (-OC(=O)NH 2), tert-butyl-OC(=O)NH-, -NH 3 +, -NH 2, -OH, -C(=O)OCH 2 CH 3, NHC(=O)NH 2, trifluoromethylsufanyl, trifluoromethyl, and -CN, Y is selected from the group consisting of O and -N-R 1; R 1 is selected from the group consisting of H and linear or branched C 1 -C 3 alkyl; R 2 is selected from the group consisting of H and halogen; A is selected from the group consisting of O and S; B is selected from the group consisting of C and N; Z is selected from the group consisting of imidazole, pyrrolidine, and tetrazole unsubstituted or substituted by at least one substituent selected from the group consisting of OH, carbamate, linear or branched C 1 -C 4 alkyl, halogen, -NO 2, -NH 2,-CF 3, -CN and phenyl; -OC(=O)NR 3 R 4; NR 5 R 6; NHC(=NH)NH 2, and -NHC(=O)NH 2; each of R 3 and R 4 is independently selected from the group consisting of H; C 1 -C 5 alkyl unsubstituted or substituted by at least one selected from the group consisting of NH 2, and NR 7 R 8; piperidine, piperazine, and diazepane unsubstituted or substituted by C 1 -C 3 alkyl; or R 3 and R 4 together may form piperidine, piperazine, imidazole, pyrrolidine, triazole, tetrazole, diazepane or morpholine unsubstituted or substituted by C 1 -C 3 alkyl; each of R 5 and R 6 is independently selected from the group consisting of C 2 -C 3 alkene; C 2 -C 3 alkyne; and linear or branched C 1 -C 4 alkyl substituted by at least one selected from the group consisting of -OH, -C NH 2, C 1 -C 3 alkoxy, and carbamate; each of R 7 and R 8 is at least one independently selected from the group consisting of H and linear or branched C 1 -C 3 alkyl, each of m and n is independently 0 or 1.