A method of immunoassay to measure neo-epitope containing protein fragments naturally present in a body fluid sample, wherein said immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with an N-terminal neo-epitope formed by cleavage of a protein by a proteinase or a C-terminal neo-epitope formed by cleavage of a protein by a proteinase, which immunological binding partner is non-reactive with the intact protein from which the epitope derives and is not reactive with a prolongated version of the neo-epitope sequence in which the neo-epitope sequence is prolonged past the cleavage site, and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, wherein said immunological binding partner specifically binds a neo-epitope constituted by an N-terminal amino acid sequence present in peptides produced by cleavage of collagen type IV, said peptides comprising an N-terminal sequence selected from the group consisting of: Collagen type IV IDGYRG... SEQ ID NO609 MGPPGT... SEQ ID NO610 DGLPGS... SEQ ID NO611 PGSKGE... SEQ ID NO612 RGFPGP... SEQ ID NO613 PGPPGL... SEQ ID NO614 GPPGPP... SEQ ID NO100 GLPGSM... SEQ ID NO615 GLPGQQ... SEQ ID NO616 PGIGVQ... SEQ ID NO618 GIGPPG... SEQ ID NO611 PGLPGI... SEQ ID NO504 PGPKGF... SEQ ID NO621 SPGIPG... SEQ ID NO619 PGMQGE... SEQ ID NO620 LGSKGE... SEQ ID NO617 KGQPGL... SEQ ID NO622 RGPPGP... SEQ ID NO148 IRGEPG... SEQ ID NO626 FPGPPG... SEQ ID NO627 GPLGEK... SEQ ID NO625 DGVIGM... SEQ ID NO629 PGNPGI... SEQ ID NO630 PGLKGD... SEQ ID NO624 IKGDKG... SEQ ID NO631 PGSPGC... SEQ ID NO632 PPSDEI... SEQ ID NO623 GPPGVP... SEQ ID NO633 DQGDQG... SEQ ID NO634 GAPGPQ... SEQ ID NO445 KGSIGI... SEQ ID NO635 GIPGAP... SEQ ID NO372 DRGPQG... SEQ ID NO442 ERGSPG... SEQ ID NO38 LQGIRG... SEQ ID NO628 DGGVPN... SEQ ID NO638 SGRDGL... SEQ ID NO639 PGPMGP... SEQ ID NO25 GPPGLM... SEQ ID NO643 DGYRGP... SEQ ID NO642 AEGLPG... SEQ ID NO641 LPGFAG... SEQ ID NO644 GIPGMP... SEQ ID NO645 PPGRLG... SEQ ID NO636 GPPGEK... SEQ ID NO640 EKGQKG... SEQ ID NO637.LPGPDG SEQ ID NO2214.PGIPGT SEQ ID NO2227 •ILGHVP SEQ ID NO2212.LRGIPG SEQ ID NO760.PGDIVF SEQ ID NO2215.PGLPGQ SEQ ID NO2213.PGFPGA SEQ ID NO2218.GNKGDP SEQ ID NO2216.SGYPGN SEQ ID NO2217.QQGNRG SEQ ID NO2221.PGPRGK SEQ ID NO2219.VSGPPG SEQ ID NO2220.VGQPGP SEQ ID NO2222.PGPPGP SEQ ID NO458.KRGPPG SEQ ID NO2223.GEPGMQ SEQ ID NO2224.SKGEKG SEQ ID NO2226.LHGFPG SEQ ID NO2225.GEPGPP SEQ ID NO675 or, wherein said immunological binding partner specifically binds a neo-epitope constituted by a C-terminal amino acid sequence present in peptides produced by cleavage of collagen type IV, said peptides comprising an C-terminal sequence selected from the group consisting of: Collagen type IV...RGPPGP SEQ ID NO148...SVDHGF SEQ ID NO646...PSVDHG SEQ ID NO647...VDHGFL SEQ ID NO648...PGQPGY SEQ ID NO649...QPGYTN SEQ ID NO650...PGLPGS SEQ ID NO651...GTPSVD SEQ ID NO652...SVGSPG SEQ ID NO653...LPGSMG SEQ ID NO654...GPPGVP SEQ ID NO633...PGFPGL SEQ ID NO655...PGLPGE SEQ ID NO656...GDPGPP SEQ ID NO373...HQGEMG SEQ ID NO657...GPPGLV SEQ ID NO658...PGIPGP SEQ ID NO659...PGFPGT SEQ ID NO660...PGLPGP SEQ ID NO58...DGIPGP SEQ ID NO661...SGPKGY SEQ ID NO662...GIGPPG SEQ ID NO611...PGPRGE SEQ ID NO663...GQGPPG SEQ ID NO664...PGAIGP SEQ ID NO668...KVDMGS SEQ ID NO665...PGIDGV SEQ ID NO666...GPKGPP SEQ ID NO671...PPGPPG SEQ ID NO119...KGHMGE SEQ ID NO667...GPKGLP SEQ ID NO670...SPGPPG SEQ ID NO672...KGLPGP SEQ ID NO669...GSVGYP SEQ ID NO673...PPGSPG SEQ ID NO674...GEPGPP SEQ ID NO675...AGNPGP SEQ ID NO676...FPGPQG SEQ ID NO679...PGYTNG SEQ ID NO678...SVDHGF SEQ ID NO646...LSGPPG SEQ ID NO680...GQGPPG SEQ ID NO664...GVMGTP SEQ ID NO681...PGIKGS SEQ ID NO677...PGPPGP SEQ ID NO458...GVSGPK SEQ ID NO682 HVPGML. SEQ ID NO2228 LPVPGQ. SEQ ID NO2229 LGPPGL. SEQ ID NO2230 GVPGQA. SEQ ID NO2231 VPGQAQ. SEQ ID NO2232 GPDGFL. SEQ ID NO2233 QEGPLG. SEQ ID NO2234 LPGEVL. SEQ ID NO2235 RGIPGF. SEQ ID NO2236 NRGLGF. SEQ ID NO2238 IPSDTL. SEQ ID NO2239 PAGEKG. SEQ ID NO2240 GEKGNK. SEQ ID NO2241 PVGPPG. SEQ ID NO2242 DIVFRK. SEQ ID NO2243 PPGPKG. SEQ ID NO167 RGKPGM. SEQ ID NO2244 PGTRGL. SEQ ID NO2245 GEKGSK. SEQ ID NO2246 EKGSKG. SEQ ID NO2247 SGQPGL. SEQ ID NO2248 AGIPQK. SEQ ID NO2237