A method for managing a blood-pressure variation of a patient, the method comprising, by a processing unit: obtaining a measure of a nocturnal blood pressure dip of the patient; determining a target exercise intensity for the patient based on the obtained measure of the nocturnal blood pressure dip including - obtaining a waking blood pressure of the patient, - calculating a target sleeping blood pressure for the patient based on the waking blood pressure and the measure of nocturnal blood pressure dip of the patient, and - calculating the target exercise intensity based on the target sleeping blood pressure; obtaining a measure of the circadian rhythm of the patient; determining a target exercise timing for the patient based on the obtained measure of the circadian rhythm including - determining a predicted timing of melatonin onset for the patient based on the measure of the circadian rhythm and processing the predicted timing of melatonin onset in accordance with one or more algorithms to calculate the target exercise timing for the patient; or - comparing the measure of circadian rhythm with a threshold value and, based on the result of the comparison and determining the target exercise timing to either be in a time window after waking or a time window before sleeping; and generating an output signal representative of the target exercise intensity and target exercise timing. obtaining a measure of a nocturnal blood pressure dip of the patient; determining a target exercise intensity for the patient based on the obtained measure of the nocturnal blood pressure dip including - obtaining a waking blood pressure of the patient, - calculating a target sleeping blood pressure for the patient based on the waking blood pressure and the measure of nocturnal blood pressure dip of the patient, and - calculating the target exercise intensity based on the target sleeping blood pressure; - obtaining a waking blood pressure of the patient, - calculating a target sleeping blood pressure for the patient based on the waking blood pressure and the measure of nocturnal blood pressure dip of the patient, and - calculating the target exercise intensity based on the target sleeping blood pressure; obtaining a measure of the circadian rhythm of the patient; determining a target exercise timing for the patient based on the obtained measure of the circadian rhythm including - determining a predicted timing of melatonin onset for the patient based on the measure of the circadian rhythm and processing the predicted timing of melatonin onset in accordance with one or more algorithms to calculate the target exercise timing for the patient; or - comparing the measure of circadian rhythm with a threshold value and, based on the result of the comparison and determining the target exercise timing to either be in a time window after waking or a time window before sleeping; and - determining a predicted timing of melatonin onset for the patient based on the measure of the circadian rhythm and processing the predicted timing of melatonin onset in accordance with one or more algorithms to calculate the target exercise timing for the patient; or - comparing the measure of circadian rhythm with a threshold value and, based on the result of the comparison and determining the target exercise timing to either be in a time window after waking or a time window before sleeping; and generating an output signal representative of the target exercise intensity and target exercise timing.