A renal neuromodulation system, comprising: an intravascular catheter comprising an elongated shaft having a proximal portion and a distal portion; a therapeutic assembly carried by the distal portion of the shaft, the therapeutic assembly being positionable within a human renal blood vessel and including a plurality of energy delivery elements configured to deliver energy to modulate nerves associated with sympathetic neural function; a pressure measurement device configured to measure pressure at or at least proximate to the plurality of energy delivery elements, the pressure measurement device having a plurality of regions (76A, 76B, 76C, 76D) that are separated by one or more non-conductive areas (75A, 75B), wherein the pressure measurement device includes a plurality of capacitive elements that individually correspond to the plurality of regions (76A, 76B, 76C, 76D); and an elongated support structure configured to take a pre-determined shape upon deployment in a vessel, wherein at least one of the energy delivery elements is disposed in a predetermined orientation on the elongated support structure, and wherein the pressure measurement device is arranged such that the plurality of regions (76A, 76B, 76C, 76D) are configured to sense pressure in a plurality of directions about at least one of the energy delivery elements, wherein the elongated support structure is shape set in a helical geometry; and a controller operably connected to the energy delivery elements and the pressure measurement device, the controller configured to obta in a plurality of pressure measurements corresponding individually to the plurality of regions (76A, 76B, 76C, 76D); and determine an orientation of the energy delivery elements relative to the vessel wall based on at least one of the plurality of pressure measurements. an intravascular catheter comprising an elongated shaft having a proximal portion and a distal portion; a therapeutic assembly carried by the distal portion of the shaft, the therapeutic assembly being positionable within a human renal blood vessel and including a plurality of energy delivery elements configured to deliver energy to modulate nerves associated with sympathetic neural function; a pressure measurement device configured to measure pressure at or at least proximate to the plurality of energy delivery elements, the pressure measurement device having a plurality of regions (76A, 76B, 76C, 76D) that are separated by one or more non-conductive areas (75A, 75B), wherein the pressure measurement device includes a plurality of capacitive elements that individually correspond to the plurality of regions (76A, 76B, 76C, 76D); and an elongated support structure configured to take a pre-determined shape upon deployment in a vessel, wherein at least one of the energy delivery elements is disposed in a predetermined orientation on the elongated support structure, and wherein the pressure measurement device is arranged such that the plurality of regions (76A, 76B, 76C, 76D) are configured to sense pressure in a plurality of directions about at least one of the energy delivery elements, wherein the elongated support structure is shape set in a helical geometry; and a plurality of energy delivery elements configured to deliver energy to modulate nerves associated with sympathetic neural function; a pressure measurement device configured to measure pressure at or at least proximate to the plurality of energy delivery elements, the pressure measurement device having a plurality of regions (76A, 76B, 76C, 76D) that are separated by one or more non-conductive areas (75A, 75B), wherein the pressure measurement device includes a plurality of capacitive elements that individually correspond to the plurality of regions (76A, 76B, 76C, 76D); and an elongated support structure configured to take a pre-determined shape upon deployment in a vessel, wherein at least one of the energy delivery elements is disposed in a predetermined orientation on the elongated support structure, and wherein the pressure measurement device is arranged such that the plurality of regions (76A, 76B, 76C, 76D) are configured to sense pressure in a plurality of directions about at least one of the energy delivery elements, wherein the elongated support structure is shape set in a helical geometry; and a controller operably connected to the energy delivery elements and the pressure measurement device, the controller configured to obta in a plurality of pressure measurements corresponding individually to the plurality of regions (76A, 76B, 76C, 76D); and determine an orientation of the energy delivery elements relative to the vessel wall based on at least one of the plurality of pressure measurements. in a plurality of pressure measurements corresponding individually to the plurality of regions (76A, 76B, 76C, 76D); and determine an orientation of the energy delivery elements relative to the vessel wall based on at least one of the plurality of pressure measurements.