A method for performing Digital Radiography according to multiple imaging modes, the method comprising the steps of: - positioning an object in between an x-ray source and an x-ray detector (6a, 6b, 9) using an object support and positioning system; - selecting a radiographic imaging modality and a desired region of interest; - adjusting, by one or more x-ray collimators (22, 24), the shape of the x-ray beam according to the selected imaging modality; - positioning the x-ray detector (6a, 6b, 9) in a predefined position into the x-ray beam; - generating x-ray radiation by the x-ray source; - performing a movement for scanning of the object while detecting the x-ray radiation by means of the x-ray detector (6a, 6b, 9); - performing a readout of the x-ray detector image data, acquisition and elaboration in order to obtain a processed image or tridimensional data set of the selected region of interest according to the selected imaging modality, characterized in that - in at least one imaging modality the x-ray detector is a large area x-ray detector of rectangular dimensions which is enclosed within an x-ray sensor cassette, that - the x-ray sensor cassette is equipped with at least one motor drive providing horizontal movement transverse to a reference axis of the x-ray beam, and that - the collimators include at least one secondary x-ray collimator utilized for cephalometric radiography in combination with a cephalometric x-ray detector, the secondary x-ray collimator being also enclosed within the x-ray sensor cassette and having a distance from the x-ray source, which is greater than the distance of the large area x-ray detector from the x-ray source. - positioning an object in between an x-ray source and an x-ray detector (6a, 6b, 9) using an object support and positioning system; - selecting a radiographic imaging modality and a desired region of interest; - adjusting, by one or more x-ray collimators (22, 24), the shape of the x-ray beam according to the selected imaging modality; - positioning the x-ray detector (6a, 6b, 9) in a predefined position into the x-ray beam; - generating x-ray radiation by the x-ray source; - performing a movement for scanning of the object while detecting the x-ray radiation by means of the x-ray detector (6a, 6b, 9); - performing a readout of the x-ray detector image data, acquisition and elaboration in order to obtain a processed image or tridimensional data set of the selected region of interest according to the selected imaging modality, characterized in that - in at least one imaging modality the x-ray detector is a large area x-ray detector of rectangular dimensions which is enclosed within an x-ray sensor cassette, that - the x-ray sensor cassette is equipped with at least one motor drive providing horizontal movement transverse to a reference axis of the x-ray beam, and that - the collimators include at least one secondary x-ray collimator utilized for cephalometric radiography in combination with a cephalometric x-ray detector, the secondary x-ray collimator being also enclosed within the x-ray sensor cassette and having a distance from the x-ray source, which is greater than the distance of the large area x-ray detector from the x-ray source.