A prosthetic device (70; 600) for treating heart valve regurgitation comprising: a radially compressible and radially expandable body (72; 602) having a first end configured to be positioned in or adjacent to a ventricle, a second end configured to be positioned in or adjacent to an atrium, and an outer surface extending from the first end to the second end; and an anchor (74; 604, 606) having a connection portion (84; 608) and a leaflet capture portion (88; 616), wherein: the connection portion (84; 608) is coupled to the body (72; 602) such that the leaflet capture portion (88; 616) is biased against the outer surface of the body (72; 602) when the body is in a radially expanded state; the prosthetic device (70; 600) is configured to capture a leaflet (6, 8) of a native heart valve between the leaflet capture portion (88; 616) of the anchor (74; 604, 606) and the outer surface of the body (72; 602), wherein when the device (70; 600) is implanted a portion of the leaflet (6, 8) is pressed against the outer surface of the body (72; 602) by the anchor (74; 604, 606); and the body (72; 602) is configured to prevent blood from flowing through the body (72; 602) in a direction extending from the first end to the second end and in a direction extending from the second end to the first end. a radially compressible and radially expandable body (72; 602) having a first end configured to be positioned in or adjacent to a ventricle, a second end configured to be positioned in or adjacent to an atrium, and an outer surface extending from the first end to the second end; and an anchor (74; 604, 606) having a connection portion (84; 608) and a leaflet capture portion (88; 616), wherein: the connection portion (84; 608) is coupled to the body (72; 602) such that the leaflet capture portion (88; 616) is biased against the outer surface of the body (72; 602) when the body is in a radially expanded state; the prosthetic device (70; 600) is configured to capture a leaflet (6, 8) of a native heart valve between the leaflet capture portion (88; 616) of the anchor (74; 604, 606) and the outer surface of the body (72; 602), wherein when the device (70; 600) is implanted a portion of the leaflet (6, 8) is pressed against the outer surface of the body (72; 602) by the anchor (74; 604, 606); and the body (72; 602) is configured to prevent blood from flowing through the body (72; 602) in a direction extending from the first end to the second end and in a direction extending from the second end to the first end. the connection portion (84; 608) is coupled to the body (72; 602) such that the leaflet capture portion (88; 616) is biased against the outer surface of the body (72; 602) when the body is in a radially expanded state; the prosthetic device (70; 600) is configured to capture a leaflet (6, 8) of a native heart valve between the leaflet capture portion (88; 616) of the anchor (74; 604, 606) and the outer surface of the body (72; 602), wherein when the device (70; 600) is implanted a portion of the leaflet (6, 8) is pressed against the outer surface of the body (72; 602) by the anchor (74; 604, 606); and the body (72; 602) is configured to prevent blood from flowing through the body (72; 602) in a direction extending from the first end to the second end and in a direction extending from the second end to the first end.