A compound of formula, wherein R 1 is heterocyclyl, said heterocyclyl being unsubstituted or substituted with one, two or three substituents independently selected from (C 1-6 alkyl) 2 aminocarbonyl, (C 1-6 alkyl) 2 morpholinylcarbonyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl, C 1-6 alkyl(C 1-6 alkylsulfonyl)amino, C 1-6 alkylaminocarbonyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylimidazolyl, C 1-6 alkylmorpholinylcarbonyl, C 1-6 alkyloxadiazolyl, C 1-6 alkyloxazolyl, C 1-6 alkylpyrazolyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonylamino, C 1-6 alkylsulfonylC 1-6 alkyl, carbamoyl, cyano, dioxopyrrolidinyl, haloC 1-6 alkyl, haloC 1-6 alkyloxadiazolyl, halogen, halopiperidinylcarbonyl, halopyridinyl, halopyrimidinylamino, halopyrimidinyloxy, halopyrrolidinylcarbonyl, hydroxy, hydroxyazetidinylcarbonyl, hydroxyC 1-6 alkyl, hydroxyC 1-6 alkyl(C 1-6 alkyl)aminocarbonyl, hydroxyC 1-6 alkylaminocarbonyl, hydroxypyrrolidinylcarbonyl, morpholinylcarbonyl, oxadiazolyl, oxazolyl, oxazolylaminocarbonyl, oxazolyl(C 1-6 alkyl)aminocarbonyl, oxazolylcarbonyl, oxazolylcarbonyl(C 1-6 alkyl)amino, oxomorpholinyl, oxooxazolidinyl, oxopyrrolidinyl, phenyl, phenylcarbonyl, pyrazolylC 1-6 alkyl, pyridinyl, pyrimidinyl, pyrimidinylamino, pyrimidinyl(C 1-6 alkyl)amino, pyrimidinyloxy, pyrimidinyloxyC 1-6 alkyl, pyrrolidinylcarbonyl and thiazolyl; heteroaryl, said heteroaryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 1-6 alkyl,haloC 1-6 alkyl, hydroxy C 1-6 alkyl and C 1-6 alkoxyC 1-6 alkyl; phenyl, said phenyl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, haloC 1-6 alkoxy and haloC 1-6 alkyl; or C 3-7 cycloalkyl; R 2 and R 3 are independently selected from hydrogen and C 1-6 alkyl; R 4 is heteroaryl, said heteroaryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl and (C 1-6 alkyl) 2 amino; aryl, said aryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 3-7 cycloalkyl, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkoxy, haloC 1-6 alkyl and haloC 1-6 alkoxy; phenylC 1-6 alkyl, said phenylC 1-6 alkyl being unsubstituted or substituted with one, two or three halogen; or C 3-7 cycloalkyl; Y and Q are independently selected from CH and N; or pharmaceutically acceptable salt, enantiomer or diastereomer thereof. R 1 is heterocyclyl, said heterocyclyl being unsubstituted or substituted with one, two or three substituents independently selected from (C 1-6 alkyl) 2 aminocarbonyl, (C 1-6 alkyl) 2 morpholinylcarbonyl, C 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl, C 1-6 alkyl(C 1-6 alkylsulfonyl)amino, C 1-6 alkylaminocarbonyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylimidazolyl, C 1-6 alkylmorpholinylcarbonyl, C 1-6 alkyloxadiazolyl, C 1-6 alkyloxazolyl, C 1-6 alkylpyrazolyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonylamino, C 1-6 alkylsulfonylC 1-6 alkyl, carbamoyl, cyano, dioxopyrrolidinyl, haloC 1-6 alkyl, haloC 1-6 alkyloxadiazolyl, halogen, halopiperidinylcarbonyl, halopyridinyl, halopyrimidinylamino, halopyrimidinyloxy, halopyrrolidinylcarbonyl, hydroxy, hydroxyazetidinylcarbonyl, hydroxyC 1-6 alkyl, hydroxyC 1-6 alkyl(C 1-6 alkyl)aminocarbonyl, hydroxyC 1-6 alkylaminocarbonyl, hydroxypyrrolidinylcarbonyl, morpholinylcarbonyl, oxadiazolyl, oxazolyl, oxazolylaminocarbonyl, oxazolyl(C 1-6 alkyl)aminocarbonyl, oxazolylcarbonyl, oxazolylcarbonyl(C 1-6 alkyl)amino, oxomorpholinyl, oxooxazolidinyl, oxopyrrolidinyl, phenyl, phenylcarbonyl, pyrazolylC 1-6 alkyl, pyridinyl, pyrimidinyl, pyrimidinylamino, pyrimidinyl(C 1-6 alkyl)amino, pyrimidinyloxy, pyrimidinyloxyC 1-6 alkyl, pyrrolidinylcarbonyl and thiazolyl; heteroaryl, said heteroaryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 1-6 alkyl,haloC 1-6 alkyl, hydroxy C 1-6 alkyl and C 1-6 alkoxyC 1-6 alkyl; phenyl, said phenyl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, haloC 1-6 alkoxy and haloC 1-6 alkyl; or C 3-7 cycloalkyl; R 2 and R 3 are independently selected from hydrogen and C 1-6 alkyl; R 4 is heteroaryl, said heteroaryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl and (C 1-6 alkyl) 2 amino; aryl, said aryl being unsubstituted or substituted with one, two or three substituents independently selected from halogen, cyano, C 3-7 cycloalkyl, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkoxy, haloC 1-6 alkyl and haloC 1-6 alkoxy; phenylC 1-6 alkyl, said phenylC 1-6 alkyl being unsubstituted or substituted with one, two or three halogen; or C 3-7 cycloalkyl; Y and Q are independently selected from CH and N;