A pharmaceutical composition comprising an EBP-modulating anti-cancer compound for use in a method of treating a tumour, the method comprising identifying a subject who will benefit from treatment with a pharmaceutical composition comprising said EBP-modulating anti-cancer compound by: (a) isolating a tumor sample comprising a population of cancer cells from the subject; (b) providing (i) an aliquot of the tumor sample in (a) as a test population of cancer cells, (ii) a known population of cancer cells sensitive to an EBP-modulating anticancer compound (positive control), and (iii) a known population of cancer cells insensitive to an EBP-modulating anticancer compound (negative control); (c) determining whether the aliquot of the tumor sample contains a subpopulation of cancer cells sensitive to a composition comprising an EBP-modulating anti-cancer compound by: contacting the known EBP-modulating anticancer compound to the populations of cancer cells in (b); measuring EBP enzyme activity and a parameter of endogenous cholesterol synthesis for each population of cancer cells, wherein an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP enzyme activity and to decrease endogenous cholesterol synthesis in a cancer cell sensitive to the known EBP modulating anti-cancer compound, while an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP activity and to increase endogenous cholesterol synthesis in a cancer cell insensitive to the EBP modulating anti-cancer compound; distinguishing the sensitive population of cancer cells from the insensitive population of cancer cells in the test population of cancer cells; and (d) if the test population of cancer cells contains a population of cancer cells sensitive to the EBP modulating anti-cancer compound, treating the tumour by administering to the subject the said pharmaceutical, wherein the EBP-modulating anti-cancer compound is selected from the group consisting of TASIN-1, dendrogenin A, SR31747A, tamoxifen, emopamil, verapamil, cis-flupentixol, trifluoroperazine, 7-ketocholestenol, haloperidol, and fenpropimorph, or a functional equivalent of TASIN-1 selected from the group consisting of: and the cancer cell sensitive to the EBP-modulating anti-cancer compound comprises a truncated APC protein. (a) isolating a tumor sample comprising a population of cancer cells from the subject; (b) providing (i) an aliquot of the tumor sample in (a) as a test population of cancer cells, (ii) a known population of cancer cells sensitive to an EBP-modulating anticancer compound (positive control), and (iii) a known population of cancer cells insensitive to an EBP-modulating anticancer compound (negative control); (c) determining whether the aliquot of the tumor sample contains a subpopulation of cancer cells sensitive to a composition comprising an EBP-modulating anti-cancer compound by: contacting the known EBP-modulating anticancer compound to the populations of cancer cells in (b); measuring EBP enzyme activity and a parameter of endogenous cholesterol synthesis for each population of cancer cells, wherein an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP enzyme activity and to decrease endogenous cholesterol synthesis in a cancer cell sensitive to the known EBP modulating anti-cancer compound, while an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP activity and to increase endogenous cholesterol synthesis in a cancer cell insensitive to the EBP modulating anti-cancer compound; distinguishing the sensitive population of cancer cells from the insensitive population of cancer cells in the test population of cancer cells; and contacting the known EBP-modulating anticancer compound to the populations of cancer cells in (b); measuring EBP enzyme activity and a parameter of endogenous cholesterol synthesis for each population of cancer cells, wherein an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP enzyme activity and to decrease endogenous cholesterol synthesis in a cancer cell sensitive to the known EBP modulating anti-cancer compound, while an amount of the EBP-modulating anti-cancer compound is effective to decrease EBP activity and to increase endogenous cholesterol synthesis in a cancer cell insensitive to the EBP modulating anti-cancer compound; distinguishing the sensitive population of cancer cells from the insensitive population of cancer cells in the test population of cancer cells; and (d) if the test population of cancer cells contains a population of cancer cells sensitive to the EBP modulating anti-cancer compound, treating the tumour by administering to the subject the said pharmaceutical, wherein the EBP-modulating anti-cancer compound is selected from the group consisting of TASIN-1, dendrogenin A, SR31747A, tamoxifen, emopamil, verapamil, cis-flupentixol, trifluoroperazine, 7-ketocholestenol, haloperidol, and fenpropimorph, or a functional equivalent of TASIN-1 selected from the group consisting of: and the cancer cell sensitive to the EBP-modulating anti-cancer compound comprises a truncated APC protein. the EBP-modulating anti-cancer compound is selected from the group consisting of TASIN-1, dendrogenin A, SR31747A, tamoxifen, emopamil, verapamil, cis-flupentixol, trifluoroperazine, 7-ketocholestenol, haloperidol, and fenpropimorph, or a functional equivalent of TASIN-1 selected from the group consisting of: and the cancer cell sensitive to the EBP-modulating anti-cancer compound comprises a truncated APC protein.