A system for performing ophthalmic surgery, comprising: a wavefront aberrometer, configured to obtain a wavefront map of an eye in its natural state to measure a refractive error; a first iris imager, in communication with the wavefront aberrometer, configured to obtain a first iris image of the eye in its natural state; a laser surgery device including, a patient interface configured to dock to the eye; a second iris imager, configured to obtain a second iris image for the docked eye; a computer processor and memory in communication with the wavefront aberrometer, configured to: determine a cutting profile to cut in a cornea of the eye in its natural state, based on the wavefront aberrometer measurement; wherein the cutting profile for the eye in its natural state includes a lenticule shape comprising a top lenticular incision and a bottom lenticular incision; and determine a translation of the cutting profile for the docked eye using the cutting profile, the iris image for the eye in its natural state and the iris image for the docked eye; and an ultrashort pulsed laser in communication with the computer processor; characterized in that: a portion of the patient interface that contacts the patient cornea comprises a liquid interface; the computer processor and memory are configured to: determine a first translation of the cutting profile based on an estimated perturbation of the eye by docking to the patient interface; and determine a second translation of the cutting profile for the docked eye using the iris image for the docked eye compared to the iris image of the eye in its natural state, wherein the second translation of the cutting profile accounts for iris distortion in the second iris image for the docked eye; and the ultrashort pulsed laser is configured to incise the bottom lenticular incision and the top lenticular incision in the cornea on the docked eye based on the first translation of the cutting profile and the second translation of the cutting profile. a wavefront aberrometer, configured to obtain a wavefront map of an eye in its natural state to measure a refractive error; a first iris imager, in communication with the wavefront aberrometer, configured to obtain a first iris image of the eye in its natural state; a laser surgery device including, a patient interface configured to dock to the eye; a second iris imager, configured to obtain a second iris image for the docked eye; a computer processor and memory in communication with the wavefront aberrometer, configured to: determine a cutting profile to cut in a cornea of the eye in its natural state, based on the wavefront aberrometer measurement; wherein the cutting profile for the eye in its natural state includes a lenticule shape comprising a top lenticular incision and a bottom lenticular incision; and determine a translation of the cutting profile for the docked eye using the cutting profile, the iris image for the eye in its natural state and the iris image for the docked eye; and an ultrashort pulsed laser in communication with the computer processor; a patient interface configured to dock to the eye; a second iris imager, configured to obtain a second iris image for the docked eye; a computer processor and memory in communication with the wavefront aberrometer, configured to: determine a cutting profile to cut in a cornea of the eye in its natural state, based on the wavefront aberrometer measurement; wherein the cutting profile for the eye in its natural state includes a lenticule shape comprising a top lenticular incision and a bottom lenticular incision; and determine a translation of the cutting profile for the docked eye using the cutting profile, the iris image for the eye in its natural state and the iris image for the docked eye; and determine a cutting profile to cut in a cornea of the eye in its natural state, based on the wavefront aberrometer measurement; wherein the cutting profile for the eye in its natural state includes a lenticule shape comprising a top lenticular incision and a bottom lenticular incision; and determine a translation of the cutting profile for the docked eye using the cutting profile, the iris image for the eye in its natural state and the iris image for the docked eye; and an ultrashort pulsed laser in communication with the computer processor; characterized in that: a portion of the patient interface that contacts the patient cornea comprises a liquid interface; determine a first translation of the cutting profile based on an estimated perturbation of the eye by docking to the patient interface; and determine a second translation of the cutting profile for the docked eye using the iris image for the docked eye compared to the iris image of the eye in its natural state, wherein the second translation of the cutting profile accounts for iris distortion in the second iris image for the docked eye; and