A system for monitoring negative-pressure treatment of a tissue site, comprising: a therapy system comprising: a negative-pressure source; a dressing fluidly coupled to the negative-pressure source for disposal on the tissue site for distributing negative pressure; a communication device coupled to the negative-pressure source and configured to transmit operational data of the negative-pressure source; the communication device comprising: a receiver configured to receive operational data from the negative-pressure source; a processor configured to process the operational data to compute one or more first usage statistics; and a transmitter configured to transmit the one or more first usage statistics to a remote monitoring center for providing an alert signal indicating a level of compliance with a prescribed protocol; wherein the remote monitoring center transmits a user message indicated non-compliance with the prescribed protocol to the therapy system for display on a graphical user interface of the therapy system to a user of the negative pressure source, and after the remote monitoring center transmits the user message monitoring usage for detecting indications of improved compliance with the prescribed protocol; and if there has not been improved compliance with the prescribed protocol triggering an alert for a clinician or compliance team member. a therapy system comprising: a negative-pressure source; a dressing fluidly coupled to the negative-pressure source for disposal on the tissue site for distributing negative pressure; a communication device coupled to the negative-pressure source and configured to transmit operational data of the negative-pressure source; a negative-pressure source; a dressing fluidly coupled to the negative-pressure source for disposal on the tissue site for distributing negative pressure; a communication device coupled to the negative-pressure source and configured to transmit operational data of the negative-pressure source; the communication device comprising: a receiver configured to receive operational data from the negative-pressure source; a processor configured to process the operational data to compute one or more first usage statistics; and a transmitter configured to transmit the one or more first usage statistics to a remote monitoring center for providing an alert signal indicating a level of compliance with a prescribed protocol; a receiver configured to receive operational data from the negative-pressure source; a processor configured to process the operational data to compute one or more first usage statistics; and a transmitter configured to transmit the one or more first usage statistics to a remote monitoring center for providing an alert signal indicating a level of compliance with a prescribed protocol; wherein the remote monitoring center transmits a user message indicated non-compliance with the prescribed protocol to the therapy system for display on a graphical user interface of the therapy system to a user of the negative pressure source, and after the remote monitoring center transmits the user message monitoring usage for detecting indications of improved compliance with the prescribed protocol; and if there has not been improved compliance with the prescribed protocol triggering an alert for a clinician or compliance team member.