A method for sequentially operating an array of biosensors within a single monitoring device to provide continuous monitoring over an extended period beyond the operating life of an individual biosensor, the method comprising: enabling a first sensor that comprises a first working electrode, wherein a first control amplifier receives an input from a first reference electrode and provides a first output to a counter electrode (412, 482), wherein the first control amplifier maintains a first specified voltage between the first reference electrode and the first working electrode, wherein at least one first current is detected at the first sensor while the first control amplifier is operative; rupturing or displacing a reservoir cap to permit a second working electrode to contact an analyte; prior to failure of the first sensor, enabling a second sensor that comprises the second working electrode, wherein the counter electrode (412, 482) is operative with the first control amplifier to maintain the first specified voltage between the first reference electrode and the second working electrode, wherein at least one second current is detected at the second sensor while the first control amplifier is operative; disabling the first control amplifier; and enabling a second control amplifier that receives a second input from a second reference electrode and provides a second output to the counter electrode (412, 482), wherein the counter electrode is operative with the second control amplifier to maintain a second specified voltage between the second reference electrode and the second working electrode, wherein at least one third current is detected at the first working electrode while the second control amplifier is operative, wherein at least one fourth current is detected at the second working electrode while the second control amplifier is operative. enabling a first sensor that comprises a first working electrode, wherein a first control amplifier receives an input from a first reference electrode and provides a first output to a counter electrode (412, 482), wherein the first control amplifier maintains a first specified voltage between the first reference electrode and the first working electrode, wherein at least one first current is detected at the first sensor while the first control amplifier is operative; rupturing or displacing a reservoir cap to permit a second working electrode to contact an analyte; prior to failure of the first sensor, enabling a second sensor that comprises the second working electrode, wherein the counter electrode (412, 482) is operative with the first control amplifier to maintain the first specified voltage between the first reference electrode and the second working electrode, wherein at least one second current is detected at the second sensor while the first control amplifier is operative; disabling the first control amplifier; and enabling a second control amplifier that receives a second input from a second reference electrode and provides a second output to the counter electrode (412, 482), wherein the counter electrode is operative with the second control amplifier to maintain a second specified voltage between the second reference electrode and the second working electrode, wherein at least one third current is detected at the first working electrode while the second control amplifier is operative, wherein at least one fourth current is detected at the second working electrode while the second control amplifier is operative.