An indexed drug containment device for an indexed drug actuation device for use in an indexed drug delivery and regulation device, the indexed drug containment device comprising: a housing and a valve, the valve disposed within the housing; a gas canister in fluid communication with the valve, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a first indexed member integral to the housing and a third indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member integral to a collar of the indexed drug actuation device, the second indexed member being a first key, the third indexed member adapted to be complementary to a fourth indexed member integral to the collar of the indexed drug actuation device, the fourth indexed member being a second key, wherein the first indexed member is non-complementary to the fourth indexed member, and wherein the third indexed member is non-complementary to the second indexed member, wherein one or more of the first and third indexed members (36, 36') are predeterminately adapted to indicate the identity of the active pharmaceutical ingredient, wherein indexing features that correspond to the identity of the active pharmaceutical ingredient are provided by one or more of different axial widths, axial juxtaposition, or different cross-sectional shapes of the first and third indexed member (36, 36') such that the indexed collar engages only the indexed drug containment device, whereby the indexing provides fully complementary members identified for the predetermined active pharmaceutical ingredient, characterized in that: the first indexed member is a first opening disposed on one side of the housing and the third indexed member is a second opening disposed on an opposite side of the housing with respect to the longitudinal axis of the gas canister. a housing and a valve, the valve disposed within the housing; a gas canister in fluid communication with the valve, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a first indexed member integral to the housing and a third indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member integral to a collar of the indexed drug actuation device, the second indexed member being a first key, the third indexed member adapted to be complementary to a fourth indexed member integral to the collar of the indexed drug actuation device, the fourth indexed member being a second key, wherein the first indexed member is non-complementary to the fourth indexed member, and wherein the third indexed member is non-complementary to the second indexed member, wherein one or more of the first and third indexed members (36, 36') are predeterminately adapted to indicate the identity of the active pharmaceutical ingredient, wherein indexing features that correspond to the identity of the active pharmaceutical ingredient are provided by one or more of different axial widths, axial juxtaposition, or different cross-sectional shapes of the first and third indexed member (36, 36') such that the indexed collar engages only the indexed drug containment device, whereby the indexing provides fully complementary members identified for the predetermined active pharmaceutical ingredient, characterized in that: the first indexed member is a first opening disposed on one side of the housing and the third indexed member is a second opening disposed on an opposite side of the housing with respect to the longitudinal axis of the gas canister.