A method (100, 200, 400) comprising: receiving patient-specific anatomical structure data (102, 202, 302, 402, 502) and patient-specific physiological data (104, 210, 322, 406, 522), wherein the anatomical structure data comprises structural information about a patient's coronary arteries, and wherein the patient-specific physiological data comprises a continuously recorded blood pressure waveform; generating, based at least in part on the anatomical structure data, an anatomical model of at least a portion of the patient's coronary arteries (106, 204, 306, 308, 310, 312, 314, 316, 318, 320, 404, 506, 508, 510, 512, 514, 516, 518, 520); determining, based at least in part on the continuously recorded blood pressure waveform, boundary conditions for a computational fluid dynamics simulation of blood flow in the anatomical model (108, 212, 334, 336, 338, 340, 408, 524, 526, 528, 530); simulating blood flow in the anatomical model using CFD and the boundary conditions (110, 208, 214, 326, 328, 330, 342, 412, 536, 538, 540); and determining, based at least in part on the simulation, one or more hemodynamic parameters associated with the patient's coronary arteries (112, 214, 344, 414, 542), characterized in that the continuously recorded blood pressure waveform is from a non-invasive measurement, and wherein determining the boundary conditions (108, 212, 334, 336, 338, 340, 408, 524, 526, 528, 530) comprises: determining, based at least in part on a blood circulation system model and the continuously recorded blood pressure waveform, volumetric blood flow rate data; determining, based at least in part on a heart chambers pressure-volume model and the volumetric blood flow rate data, ventricle pressure data; determining, based at least in part on a coronary blood flow model, the continuously recorded blood pressure waveform, and the ventricle pressure data, coronary artery inlet flow data, and determining, based at least in part on an allometric scaling law and the coronary artery inlet flow data, coronary artery outlet flow data. receiving patient-specific anatomical structure data (102, 202, 302, 402, 502) and patient-specific physiological data (104, 210, 322, 406, 522), wherein the anatomical structure data comprises structural information about a patient's coronary arteries, and wherein the patient-specific physiological data comprises a continuously recorded blood pressure waveform; generating, based at least in part on the anatomical structure data, an anatomical model of at least a portion of the patient's coronary arteries (106, 204, 306, 308, 310, 312, 314, 316, 318, 320, 404, 506, 508, 510, 512, 514, 516, 518, 520); determining, based at least in part on the continuously recorded blood pressure waveform, boundary conditions for a computational fluid dynamics simulation of blood flow in the anatomical model (108, 212, 334, 336, 338, 340, 408, 524, 526, 528, 530); simulating blood flow in the anatomical model using CFD and the boundary conditions (110, 208, 214, 326, 328, 330, 342, 412, 536, 538, 540); and determining, based at least in part on the simulation, one or more hemodynamic parameters associated with the patient's coronary arteries (112, 214, 344, 414, 542), characterized in that the continuously recorded blood pressure waveform is from a non-invasive measurement, and wherein determining the boundary conditions (108, 212, 334, 336, 338, 340, 408, 524, 526, 528, 530) comprises: determining, based at least in part on a blood circulation system model and the continuously recorded blood pressure waveform, volumetric blood flow rate data; determining, based at least in part on a heart chambers pressure-volume model and the volumetric blood flow rate data, ventricle pressure data; determining, based at least in part on a coronary blood flow model, the continuously recorded blood pressure waveform, and the ventricle pressure data, coronary artery inlet flow data, and determining, based at least in part on an allometric scaling law and the coronary artery inlet flow data, coronary artery outlet flow data. determining, based at least in part on a blood circulation system model and the continuously recorded blood pressure waveform, volumetric blood flow rate data; determining, based at least in part on a heart chambers pressure-volume model and the volumetric blood flow rate data, ventricle pressure data; determining, based at least in part on a coronary blood flow model, the continuously recorded blood pressure waveform, and the ventricle pressure data, coronary artery inlet flow data, and determining, based at least in part on an allometric scaling law and the coronary artery inlet flow data, coronary artery outlet flow data.