An article of footwear having a forefoot region, a midfoot region, and a heel region along a longitudinal axis of the article of footwear, the article of footwear comprising: an upper; and a sole structure including a bladder (1036, 3100), wherein the bladder includes a bulbous portion (1038, 1040a, 1040b, 1040c, 1042a, 1042b, 1042c), and wherein the bladder comprises at least a first multi-layered film (1076, 2160, 3110a, 3110b) having a plurality of gas-barrier layers and a plurality of elastomeric layers, wherein the gas-barrier layers alternate with the elastomeric layers; characterised in that the article of footwear further includes one or more of the following features (a) to (c): a) the bladder comprises a second multi-layered film, optionally wherein a structure of the second multi-layered film differs from a structure of the first multi-layered film in number of gas-barrier layers and elastomeric layers, or differs in thickness of gas-barrier layers and elastomeric layers, or differs in both number and thickness of gas-barrier layers and elastomeric layers; b) the bulbous portion extends a first distance beyond a biteline of the article of footwear in the uncompressed state and a second distance beyond the biteline in the compressed state, wherein a difference between the first distance and the second distance ranges from about 1.0 millimeter to about 3.0 millimeters; and c) the article of footwear further comprises an outsole disposed on an exterior surface of the bladder and the bulbous portion is a bulbous heel portion, wherein a geometry of the bulbous heel portion in the uncompressed state defines a first vector extending from a rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the midsole chassis, and a second vector extending from the rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the outsole, wherein the first vector and the second vector extend from each other at an angle ranging from about 115.0 degrees to about 137.5 degrees. an upper; and a sole structure including a bladder (1036, 3100), wherein the bladder includes a bulbous portion (1038, 1040a, 1040b, 1040c, 1042a, 1042b, 1042c), and wherein the bladder comprises at least a first multi-layered film (1076, 2160, 3110a, 3110b) having a plurality of gas-barrier layers and a plurality of elastomeric layers, wherein the gas-barrier layers alternate with the elastomeric layers; characterised in that the article of footwear further includes one or more of the following features (a) to (c): a) the bladder comprises a second multi-layered film, optionally wherein a structure of the second multi-layered film differs from a structure of the first multi-layered film in number of gas-barrier layers and elastomeric layers, or differs in thickness of gas-barrier layers and elastomeric layers, or differs in both number and thickness of gas-barrier layers and elastomeric layers; b) the bulbous portion extends a first distance beyond a biteline of the article of footwear in the uncompressed state and a second distance beyond the biteline in the compressed state, wherein a difference between the first distance and the second distance ranges from about 1.0 millimeter to about 3.0 millimeters; and c) the article of footwear further comprises an outsole disposed on an exterior surface of the bladder and the bulbous portion is a bulbous heel portion, wherein a geometry of the bulbous heel portion in the uncompressed state defines a first vector extending from a rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the midsole chassis, and a second vector extending from the rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the outsole, wherein the first vector and the second vector extend from each other at an angle ranging from about 115.0 degrees to about 137.5 degrees. a) the bladder comprises a second multi-layered film, optionally wherein a structure of the second multi-layered film differs from a structure of the first multi-layered film in number of gas-barrier layers and elastomeric layers, or differs in thickness of gas-barrier layers and elastomeric layers, or differs in both number and thickness of gas-barrier layers and elastomeric layers; b) the bulbous portion extends a first distance beyond a biteline of the article of footwear in the uncompressed state and a second distance beyond the biteline in the compressed state, wherein a difference between the first distance and the second distance ranges from about 1.0 millimeter to about 3.0 millimeters; and c) the article of footwear further comprises an outsole disposed on an exterior surface of the bladder and the bulbous portion is a bulbous heel portion, wherein a geometry of the bulbous heel portion in the uncompressed state defines a first vector extending from a rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the midsole chassis, and a second vector extending from the rearward-most point of the uncompressed bulbous heel portion to a rearward-most point of the outsole, wherein the first vector and the second vector extend from each other at an angle ranging from about 115.0 degrees to about 137.5 degrees.