mhurhangee/ep-ind-claims huggingface dataset:
Use of primers to amplify a target nucleic acid in the kinase domain of the erbB1 gene, in a method which predicts the likelihood of effectiveness of an EGFR tyrosine kinase inhibitor to treat cancer in a patient affected with cancer by detecting whether the target nucleic acid comprises at least one nucleic acid variance or mutation, wherein the presence of the at least one nucleic acid variance indicates the EGFR tyrosine kinase inhibitor is likely to be effective, wherein the variance or mutation, is selected from: a. a mutation in exon 18 that results in a substitution of cysteine for glycine at codon 719 of SEQ. ID. NO: 511 (G719C) or in a substitution of serine for glycine at codon 719 of SEQ. ID. NO: 511 (G719S); b. an in-frame deletion in exon 19 that results in a deletion of at least amino acids leucine, arginine, glutamic acid and alanine at codons 747, 748, 749, and 750 of SEQ. ID. NO: 511; or c. a mutation in exon 21 that results in an amino acid substitution of arginine for leucine at codon 858 of SEQ. ID. NO: 511 (L858R) or of glutamine for leucine at codon 861 of SEQ. ID. NO: 511 (L861Q). a. a mutation in exon 18 that results in a substitution of cysteine for glycine at codon 719 of SEQ. ID. NO: 511 (G719C) or in a substitution of serine for glycine at codon 719 of SEQ. ID. NO: 511 (G719S); b. an in-frame deletion in exon 19 that results in a deletion of at least amino acids leucine, arginine, glutamic acid and alanine at codons 747, 748, 749, and 750 of SEQ. ID. NO: 511; or c. a mutation in exon 21 that results in an amino acid substitution of arginine for leucine at codon 858 of SEQ. ID. NO: 511 (L858R) or of glutamine for leucine at codon 861 of SEQ. ID. NO: 511 (L861Q).
A method of synthesizing a bicyclo[3.3.0]octene compound, the method comprising contacting a compound of formula ("compound "): wherein R1, R2, and R3 are independently H or (C 1 -C 4)alkyl, or R1 and R3 are bonded together to form a (C 1 -C 4)alkylene and R2 is H or (C 1 -C 4)alkyl, with a compound of formula ("compound "): wherein R4 is H or (C 1 -C 4)alkyl, in the presence of an effective amount of a phosphoric and sulfonic acid reagent and under reaction conditions sufficient to make a compound of formula ("compound "): and/or its oxo/R4 regioisomer; wherein R1 to R4 are as defined above; and wherein the phosphoric and sulfonic acid reagent is a mixture of a phosphorous pentoxide and methanesulfonic acid ("P 2 O 5 /H 3 CSO 3 H mixture"), or a reaction product thereof; or a combination of a polyphosphoric acid and a P 2 O 5 /H 3 CSO 3 H mixture, or a reaction product thereof.
A multi-use transfer mold comprising: a transfer substrate comprising a plurality of pixels, and a first groove and a second groove provided in each of the plurality of pixels, wherein the first groove comprises a first transfer area configured to accommodate a transfer micro-light-emitting device, and a first preliminary area connected to the first transfer area and configured to accommodate a preliminary micro-light-emitting device, wherein the first preliminary area comprises a first outlet configured to allow the preliminary micro-light-emitting device to move to the first transfer area, wherein the second groove comprises a second transfer area configured to accommodate the transfer micro-light-emitting device, and a second preliminary area connected to the second transfer area and configured to accommodate the preliminary micro-light-emitting device, and wherein the second preliminary area comprises a second outlet configured to allow the preliminary micro-light-emitting device to move to the second transfer area. a transfer substrate comprising a plurality of pixels, and a first groove and a second groove provided in each of the plurality of pixels, wherein the first groove comprises a first transfer area configured to accommodate a transfer micro-light-emitting device, and a first preliminary area connected to the first transfer area and configured to accommodate a preliminary micro-light-emitting device, wherein the first preliminary area comprises a first outlet configured to allow the preliminary micro-light-emitting device to move to the first transfer area, wherein the second groove comprises a second transfer area configured to accommodate the transfer micro-light-emitting device, and a second preliminary area connected to the second transfer area and configured to accommodate the preliminary micro-light-emitting device, and wherein the second preliminary area comprises a second outlet configured to allow the preliminary micro-light-emitting device to move to the second transfer area.
A system, comprising: at least one transmitter antenna positioned in a borehole within a subterranean formation and configured to transmit a signal into the subterranean formation; at least two receiver antennas (302, 304) coupled to one or more tools positioned in the borehole within the subterranean formation and configured to receive one or more measurements of the subterranean formation associated with the transmitted signal, wherein the at least two receiver antennas are arranged at different lateral positions with respect to the borehole in a non-parallel orientation with respect to each other and in differing azimuthal directions relative to the one or more tools; and an information handling system communicably coupled to the at least two receiver antennas, and characterised in that the information handling system is configured to receive the one or more measurements from the at least two receiver antennas, to determine a measurement for a pseudo receiver antenna having a different lateral position along the length of the one or more tools from the positions of the at least two receiver antennas and a different azimuthal direction from the azimuthal directions of the at least two receiver antennas, the determined measurements being based, at least in part, on the received one or more measurements and to determine one or more characteristics of the formation from the determined measurement. at least one transmitter antenna positioned in a borehole within a subterranean formation and configured to transmit a signal into the subterranean formation; at least two receiver antennas (302, 304) coupled to one or more tools positioned in the borehole within the subterranean formation and configured to receive one or more measurements of the subterranean formation associated with the transmitted signal, wherein the at least two receiver antennas are arranged at different lateral positions with respect to the borehole in a non-parallel orientation with respect to each other and in differing azimuthal directions relative to the one or more tools; and an information handling system communicably coupled to the at least two receiver antennas, and characterised in that the information handling system is configured to receive the one or more measurements from the at least two receiver antennas, to determine a measurement for a pseudo receiver antenna having a different lateral position along the length of the one or more tools from the positions of the at least two receiver antennas and a different azimuthal direction from the azimuthal directions of the at least two receiver antennas, the determined measurements being based, at least in part, on the received one or more measurements and to determine one or more characteristics of the formation from the determined measurement.
Diesel oxidation catalyst comprising a carrier body having a length L extending between a first end face a and a second end face b, and variously composed catalytically active material zones A and B arranged on the carrier body, wherein - material zone A contains palladium or platinum and palladium in a weight ratio Pt: Pd of ≤ 1 and extends starting from end face a over 20 to 80% of length L, and - material zone B contains platinum and palladium in a weight ratio Pt: Pd of < 10 and extends over 80 to 100% of length L, and wherein material zone B is arranged above material zone A and the weight ratio Pt: Pd relative to the material zones A and B is 1.5 to 3.0 and wherein the support body is a flow-through honeycomb element. a carrier body having a length L extending between a first end face a and a second end face b, and variously composed catalytically active material zones A and B arranged on the carrier body, wherein - material zone A contains palladium or platinum and palladium in a weight ratio Pt: Pd of ≤ 1 and extends starting from end face a over 20 to 80% of length L, and - material zone B contains platinum and palladium in a weight ratio Pt: Pd of < 10 and extends over 80 to 100% of length L, and - material zone A contains palladium or platinum and palladium in a weight ratio Pt: Pd of ≤ 1 and extends starting from end face a over 20 to 80% of length L, and - material zone B contains platinum and palladium in a weight ratio Pt: Pd of < 10 and extends over 80 to 100% of length L, and wherein material zone B is arranged above material zone A and the weight ratio Pt: Pd relative to the material zones A and B is 1.5 to 3.0 and wherein the support body is a flow-through honeycomb element.
A cargo ship comprising at least one Magnus rotor, an outside wall and a gangway for going on to and leaving the ship, characterised in that the gangway has a floor having a lower surface which in the travel position of the gangway goes continuously into the surface of the outside wall and in the travel position is accommodated within a recess in the outside wall, and the lower surface of the gangway is a closed surface and is adapted to completely close the recess in the travel position, so that the air can flow substantially laminarly and without additional eddy formation past the recess.
A joint lock having a lock body and a joint bar hoop, wherein the lock body accommodates a lock cylinder and a latch which is selectively movable by the lock cylinder from a locking position into a release position, and wherein the joint bar hoop comprises a plurality of joint bars pivotally connected to one another, with a first end of the joint bar hoop having an elongate locking bar which can be introduced into an introduction opening of the lock body and which can be locked in the lock body by means of the latch, wherein the lock body furthermore accommodates a preloading device which preloads the latch into the locking position, with the latch being temporarily movable against the preload from the locking position into the release position by introduction of the locking bar into the lock body, with the preloading device being adapted to move the latch back into the locking position again when the locking bar is completely introduced into the lock body; and wherein the locking bar has at a free end a locking section which is in operational engagement with the latch in the locking position of the latch to lock the locking bar in the lock body, characterized in that the locking section of the locking bar is formed by an elevated securing portion.
A honeycomb structured body comprising: a plurality of silicon carbide-based honeycomb fired bodies bonded with one another by adhesive layers residing therebetween, the plurality of silicon carbide-based honeycomb fired bodies each comprising a large number of cells longitudinally disposed in parallel with one another with a cell wall being interposed therebetween, either one end of each of the cells being sealed, wherein the honeycomb fired bodies comprise silicon carbide particles having a surface coated with a silicon-containing oxide layer, and the adhesive layers comprise at least alumina fibers and inorganic balloons, wherein the oxide layer has a thickness of 100 to 600 nm, and wherein the amount of the inorganic balloons is 5.0 to 50.0 vol%. a plurality of silicon carbide-based honeycomb fired bodies bonded with one another by adhesive layers residing therebetween, the plurality of silicon carbide-based honeycomb fired bodies each comprising a large number of cells longitudinally disposed in parallel with one another with a cell wall being interposed therebetween, either one end of each of the cells being sealed, wherein the honeycomb fired bodies comprise silicon carbide particles having a surface coated with a silicon-containing oxide layer, and the adhesive layers comprise at least alumina fibers and inorganic balloons, wherein the oxide layer has a thickness of 100 to 600 nm, and wherein the amount of the inorganic balloons is 5.0 to 50.0 vol%.
A dipole antenna comprising: a balun, wherein the balun comprises two sides (405, 410), the sides having metal contact end portions for electrical connection to a printed circuit board; two radiating elements (412, 414), each radiating element in coplanar relationship to a corresponding side of the balun; an antenna support member, having a spacer portion placed between the two sides of the balun, wherein the spacer portion separates one radiating element of the dipole antenna from another radiating element of the dipole antenna, and characterized in that the dipole antenna is a folded metal sheet antenna having three folds. a balun, wherein the balun comprises two sides (405, 410), the sides having metal contact end portions for electrical connection to a printed circuit board; two radiating elements (412, 414), each radiating element in coplanar relationship to a corresponding side of the balun; an antenna support member, having a spacer portion placed between the two sides of the balun, wherein the spacer portion separates one radiating element of the dipole antenna from another radiating element of the dipole antenna, and characterized in that the dipole antenna is a folded metal sheet antenna having three folds.
A method for inactivating virus or bacteria in cell culture media while the media maintains suitability for cell culture, said method comprising (a) subjecting the cell culture media to high temperature short time (HTST) treatment; and (b) adjusting one or more parameters selected from the group consisting of pH, calcium level and phosphate level, whereby precipitate formation is suppressed, wherein the HTST treatment comprises raising the temperature of the media to at least about 85 degrees Celsius for a sufficient amount of time to inactivate virus or bacteria in the media, a) wherein the pH is adjusted when the media comprises calcium and phosphate, the pH is adjusted in preparing the media prior to HTST treatment to a suitable low level, and the pH is adjusted following HTST treatment to a suitable level for cell culture; b) wherein the calcium level is adjusted when the media comprises phosphate, the calcium level is reduced such that formation of complexes comprised of calcium and phosphate is suppressed, and the calcium level is adjusted following HTST treatment to a suitable level for cell culture; or c) wherein the phosphate level is adjusted when the media comprises calcium, the phosphate level is reduced such that formation of complexes comprised of calcium and phosphate is suppressed, and the phosphate level is adjusted following HTST treatment to a suitable level for cell culture. a) wherein the pH is adjusted when the media comprises calcium and phosphate, the pH is adjusted in preparing the media prior to HTST treatment to a suitable low level, and the pH is adjusted following HTST treatment to a suitable level for cell culture; b) wherein the calcium level is adjusted when the media comprises phosphate, the calcium level is reduced such that formation of complexes comprised of calcium and phosphate is suppressed, and the calcium level is adjusted following HTST treatment to a suitable level for cell culture; or c) wherein the phosphate level is adjusted when the media comprises calcium, the phosphate level is reduced such that formation of complexes comprised of calcium and phosphate is suppressed, and the phosphate level is adjusted following HTST treatment to a suitable level for cell culture.
Composition comprising: at least one N-acyl-amino acid surfactant as component A, wherein component A consists of at least one C 8 -C 22 -acylated amino acid and is selected from the group consisting of acyl glycinate, acyl aspartate, acyl glutamate, acyl sarcosinate, their salts and mixtures thereof, at least one N-methyl-N-acylglucamine as component B, at least one C 8 -C 22 -fatty acid or a fatty acid salt as component C, at least one oily substance as component D, optionally at least one acyl isethionate as component E, optionally at least one anionic, sulfonated surfactant as component F, optionally at least one betaine surfactant as component G, optionally at least one additive as component H, and water. at least one N-acyl-amino acid surfactant as component A, wherein component A consists of at least one C 8 -C 22 -acylated amino acid and is selected from the group consisting of acyl glycinate, acyl aspartate, acyl glutamate, acyl sarcosinate, their salts and mixtures thereof, at least one N-methyl-N-acylglucamine as component B, at least one C 8 -C 22 -fatty acid or a fatty acid salt as component C, at least one oily substance as component D, optionally at least one acyl isethionate as component E, optionally at least one anionic, sulfonated surfactant as component F, optionally at least one betaine surfactant as component G, optionally at least one additive as component H, and water.
An air treatment unit for an air-to-air heat pump conditioning plant used to heat the air of an inside environment of a building, the air treatment unit comprising an external heat exchanger, which normally works as an evaporator, a first inner compartment, first fan means arranged in the first compartment to generate a first air flow, and an internal heat exchanger, which is arranged in the first compartment and normally acts as a condenser to heat the first air flow; the first compartment having a delivery opening to normally deliver the first air flow into the inside environment; the air treatment unit being characterized in that said first compartment has a first expulsion opening to expel air towards an outside environment, and in that it comprises first closing means, which can be controlled by electronic control means of the plant so as to close the delivery opening during a temporary reversal of the refrigeration cycle of the heat pump of the plant, and second closing means, which can be controlled by the electronic control means so as to normally leave the first expulsion opening closed and open it during said temporary reversal of the refrigeration cycle so as to expel the first air flow (33; 34) from the first compartment.
An addition-fragmentation oligomer of the formula: wherein R A is a (hetero)hydrocarbyl group; R B is each independently a (hetero)hydrocarbyl group; R C is each independently a (hetero)hydrocarbyl group; subscript a is greater than 1; FG 1, FG 2 and FG 3 are each independently functional groups connected the depicted R A, R B and R C groups; wherein FG 1, FG 2 and FG 3 are selected from ester, amide, urea, urethane, ether, amine, anhydride, thioester, thioether functional groups, and Z comprises an ethylenically unsaturated polymerizable group. R A is a (hetero)hydrocarbyl group; R B is each independently a (hetero)hydrocarbyl group; R C is each independently a (hetero)hydrocarbyl group; subscript a is greater than 1; FG 1, FG 2 and FG 3 are each independently functional groups connected the depicted R A, R B and R C groups; wherein FG 1, FG 2 and FG 3 are selected from ester, amide, urea, urethane, ether, amine, anhydride, thioester, thioether functional groups, and Z comprises an ethylenically unsaturated polymerizable group.
Method for determining a hysteresis curve of an electromagnetically driveable valve made of an electromagnet (2, 2a, 2b), an armature which is movable by the electromagnet (2, 2a, 2b) and a valve body with means (4, 4a, 4b, 4c) for converting a movement of the armature into an opening or closing of the valve, wherein the electromagnet (2, 2a, 2b) and the armature are inserted into the valve body, wherein a magnetic hysteresis curve of a combination of the electromagnet (2, 2a, 2b) with a test armature resting against said electromagnet (2, 2a, 2b) is recorded before the electromagnet (2, 2a, 2b) is inserted into the valve body, characterized in that the gradient m 1 of a first, substantially linear curve section of the hysteresis curve is determined in the unsaturated state and in that the gradient m 1 * of a curve section of a hysteresis curve, corresponding to the first curve section, of the fully assembled valve with an armature permanently resting against the electromagnet (2, 2a, 2b) is determined from the gradient m 1.
A display device with a built-in touch screen, comprising: a substrate comprising a display area; (M ∗ n) pixels, each comprising m subpixels in the display area, where: n is a natural number, m is 3 or 4, and M is an even number when m is 3 and is a natural number when m is 4; [(M ∗ m/2) + 1] data lines on the substrate; 2n gate lines that cross the data lines on the substrate; and a plurality of touch electrodes on the substrate, wherein each of n rows of the subpixels is defined by an odd-numbered gate line and an even-numbered gate line that are continuous among the 2n gate lines, and wherein [(M ∗ m/2) - 1] data lines of the [M ∗ m/2 + 1] data lines are connected to a pair of subpixels in each of the n rows of subpixels, such that each data line of the [M ∗ m/2 - 1] data lines is shared by a pair of subpixels in each of the n rows of subpixels, wherein the first data line and the [(M ∗ m/2) + 1] th data line are at both edges in a horizontal direction of the display area of the substrate, wherein the display device further comprises first and second dummy subpixels outside the first data line and the [(M ∗ m/2) + 1] th data line at both edges in the horizontal direction of the display area, wherein the subpixels overlap the plurality of touch electrodes; and the first and second dummy subpixels partially overlap the touch electrodes. a substrate comprising a display area; (M ∗ n) pixels, each comprising m subpixels in the display area, where: n is a natural number, m is 3 or 4, and M is an even number when m is 3 and is a natural number when m is 4; n is a natural number, m is 3 or 4, and M is an even number when m is 3 and is a natural number when m is 4; [(M ∗ m/2) + 1] data lines on the substrate; 2n gate lines that cross the data lines on the substrate; and a plurality of touch electrodes on the substrate, wherein each of n rows of the subpixels is defined by an odd-numbered gate line and an even-numbered gate line that are continuous among the 2n gate lines, and wherein [(M ∗ m/2) - 1] data lines of the [M ∗ m/2 + 1] data lines are connected to a pair of subpixels in each of the n rows of subpixels, such that each data line of the [M ∗ m/2 - 1] data lines is shared by a pair of subpixels in each of the n rows of subpixels, wherein the first data line and the [(M ∗ m/2) + 1] th data line are at both edges in a horizontal direction of the display area of the substrate, wherein the display device further comprises first and second dummy subpixels outside the first data line and the [(M ∗ m/2) + 1] th data line at both edges in the horizontal direction of the display area, wherein the subpixels overlap the plurality of touch electrodes; and the first and second dummy subpixels partially overlap the touch electrodes.