Machine for producing tiles from a block, in particular a block of marble, granite and the like, said machine comprising a support surface for supporting said block, a plurality of first cutting means (D1,..., Dn) for cutting said block parallel to a first horizontal line, said first cutting means (D1,..., Dn) being arranged above said support surface, comprising respective lower edges, configured for cutting said block longitudinally on the upper part, said lower edges being arranged at the same adjustable height, with reference to a vertical line, and being arranged with an axis aligned along at least a first horizontal axis (y'), parallel to a second horizontal line, orthogonal to said first horizontal line; in that said machine comprises a second cutting means for cutting said block transversally, i.e. parallel to said second horizontal line, said second cutting means being configured to move along a second horizontal axis (y") relative to said support surface, said second horizontal axis (y") being parallel or inclined by a first angle α<90°, with respect to said second horizontal line, said second cutting means comprising a resting position, wherein it does not interact with the block, and a working position, wherein it comprises a lower edge arranged at said same adjustable height as said first cutting means (D1,..., Dn); characterised in that said machine comprises a horizontal blade for cutting said longitudinally and transversally cut block along a horizontal plane, said horizontal blade comprising a first cutting edge arranged at said same adjustable height as said first cutting means (D1,..., Dn); in that said support surface is apt to move on said horizontal line along a first cutting direction, relative to said first cutting means (D1,..., Dn), to said second cutting means, and to said horizontal blade, said horizontal blade being arranged downstream of said first horizontal axis (y') and said second horizontal axis (y"), with reference to said first cutting direction. a plurality of first cutting means (D1,..., Dn) for cutting said block parallel to a first horizontal line, said first cutting means (D1,..., Dn) being arranged above said support surface, comprising respective lower edges, configured for cutting said block longitudinally on the upper part, said lower edges being arranged at the same adjustable height, with reference to a vertical line, and being arranged with an axis aligned along at least a first horizontal axis (y'), parallel to a second horizontal line, orthogonal to said first horizontal line; in that said machine comprises a second cutting means for cutting said block transversally, i.e. parallel to said second horizontal line, said second cutting means being configured to move along a second horizontal axis (y") relative to said support surface, said second horizontal axis (y") being parallel or inclined by a first angle α<90°, with respect to said second horizontal line, said second cutting means comprising a resting position, wherein it does not interact with the block, and a working position, wherein it comprises a lower edge arranged at said same adjustable height as said first cutting means (D1,..., Dn); characterised in that said machine comprises a horizontal blade for cutting said longitudinally and transversally cut block along a horizontal plane, said horizontal blade comprising a first cutting edge arranged at said same adjustable height as said first cutting means (D1,..., Dn); in that said support surface is apt to move on said horizontal line along a first cutting direction, relative to said first cutting means (D1,..., Dn), to said second cutting means, and to said horizontal blade, said horizontal blade being arranged downstream of said first horizontal axis (y') and said second horizontal axis (y"), with reference to said first cutting direction.