mhurhangee/ep-ind-claims huggingface dataset:
A genetically modified mouse, comprising: a null mutation in the mouse SIRPα gene at the mouse SIRPα gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human SIRPα protein and is operably linked to an endogenous mouse SIRPα gene promoter at the mouse SIRPα gene locus; and a null mutation in the mouse IL-15 gene at the mouse IL-15 gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human IL-15 protein and is operably linked to an endogenous mouse IL-15 gene promoter at the mouse IL-15 gene locus, wherein the genetically modified mouse expresses the human SIRPα protein and the human IL-15 protein, wherein the genetically modified mouse is immunodeficient and comprises a Rag2 gene knock-out and an IL2rg gene knock-out, a Rag2 gene knock-out, or an IL2rg gene knock-out, and wherein when the genetically modified mouse comprises an engraftment of human hematopoietic cells, the genetically modified mouse comprises human intraepithelial lymphocytes (IELs) in the lung, or small intestine and Peyer's patches, of the genetically modified mouse. a null mutation in the mouse SIRPα gene at the mouse SIRPα gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human SIRPα protein and is operably linked to an endogenous mouse SIRPα gene promoter at the mouse SIRPα gene locus; and a null mutation in the mouse IL-15 gene at the mouse IL-15 gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human IL-15 protein and is operably linked to an endogenous mouse IL-15 gene promoter at the mouse IL-15 gene locus, wherein the genetically modified mouse expresses the human SIRPα protein and the human IL-15 protein, wherein the genetically modified mouse is immunodeficient and comprises a Rag2 gene knock-out and an IL2rg gene knock-out, a Rag2 gene knock-out, or an IL2rg gene knock-out, and wherein when the genetically modified mouse comprises an engraftment of human hematopoietic cells, the genetically modified mouse comprises human intraepithelial lymphocytes (IELs) in the lung, or small intestine and Peyer's patches, of the genetically modified mouse.
A method of positioning an inlet guide vane assembly before start-up of a chiller system including a compressor having a motor, a condenser, and a cooler, characterized in that the method comprises: receiving a first input from sensors located in the cooler and the condenser when the motor is in an idle, non-rotating state; calculating a saturation temperature in the cooler and a saturation temperature in the condenser based on the input from the sensors; receiving a second input indicative of a minimum speed of a motor coupled to the compressor at start-up; determining an allowable position of the inlet guide vane assembly based on the higher one of the calculated saturation temperatures and the second input; and moving the inlet guide vane assembly to the determined allowable position. receiving a first input from sensors located in the cooler and the condenser when the motor is in an idle, non-rotating state; calculating a saturation temperature in the cooler and a saturation temperature in the condenser based on the input from the sensors; receiving a second input indicative of a minimum speed of a motor coupled to the compressor at start-up; determining an allowable position of the inlet guide vane assembly based on the higher one of the calculated saturation temperatures and the second input; and moving the inlet guide vane assembly to the determined allowable position.
A dual-bearing reel, comprising: a first reel body; a second reel body; a first bearing member attached to the first reel body; a second bearing member attached to the second reel body; a spool disposed between the first reel body and the second reel body; a spool shaft including a first protruding part and being supported by the first and second bearing members, characterised by the first protruding part radially protruding between the first bearing member and the second bearing member; and by a first urging member disposed between the first protruding part and the first bearing member and urging the first protruding part and the first bearing member in opposite directions. a first reel body; a second reel body; a first bearing member attached to the first reel body; a second bearing member attached to the second reel body; a spool disposed between the first reel body and the second reel body; a spool shaft including a first protruding part and being supported by the first and second bearing members, characterised by the first protruding part radially protruding between the first bearing member and the second bearing member; and by a first urging member disposed between the first protruding part and the first bearing member and urging the first protruding part and the first bearing member in opposite directions.
Method for producing a three-dimensionally shaped surface protection element for a housing of an electronic device, wherein a synthetic resin printing method is used to print a curable synthetic resin composition forming a scratch protection coating as droplets pixel by pixel in a printing pattern on a substrate in the form of a three-dimensional carrier element or a three-dimensional surface area of the device, and the printed synthetic resin composition is then cured.
A system for use during administration of cardiopulmonary resuscitation, CPR, chest compressions and defibrillating shock on a victim, the system comprising: a chest compression monitor comprising a motion sensor configured to provide signals indicative of motion of the chest of the victim during the chest compressions; and a control system operatively coupled to the chest compression monitor, the control system configured to: receive the signals from the chest compression monitor to determine a compression waveform representative of the chest compressions experienced by the victim, determine at least one compression waveform characteristic from the compression waveform, determine a source of the chest compressions based on the at least one compression waveform characteristic, predetermined compression waveform characteristics for manual chest compressions provided by a CPR provider, and predetermined compression waveform characteristics for automated chest compressions provided by a piston-based chest compression device, and provide feedback for a rescuer, wherein the feedback is based on the determined source of the chest compressions. a chest compression monitor comprising a motion sensor configured to provide signals indicative of motion of the chest of the victim during the chest compressions; and a control system operatively coupled to the chest compression monitor, the control system configured to: receive the signals from the chest compression monitor to determine a compression waveform representative of the chest compressions experienced by the victim, determine at least one compression waveform characteristic from the compression waveform, determine a source of the chest compressions based on the at least one compression waveform characteristic, predetermined compression waveform characteristics for manual chest compressions provided by a CPR provider, and predetermined compression waveform characteristics for automated chest compressions provided by a piston-based chest compression device, and provide feedback for a rescuer, wherein the feedback is based on the determined source of the chest compressions. receive the signals from the chest compression monitor to determine a compression waveform representative of the chest compressions experienced by the victim, determine at least one compression waveform characteristic from the compression waveform, determine a source of the chest compressions based on the at least one compression waveform characteristic, predetermined compression waveform characteristics for manual chest compressions provided by a CPR provider, and predetermined compression waveform characteristics for automated chest compressions provided by a piston-based chest compression device, and provide feedback for a rescuer, wherein the feedback is based on the determined source of the chest compressions.
A temperature control system for a vehicle, comprising a first coolant loop with a first heat exchanger being configured to exchange heat with a first part of the vehicle and being arranged fluidically between a first inlet and a first outlet, a second coolant loop with a second heat exchanger being configured to exchange heat with a second part of the vehicle and being arranged fluidically between a second inlet and a second outlet, a coolant heating loop with a conduit portion being thermally coupled to a condenser of a heat pump unit being configured to selectively heat the coolant, wherein the conduit portion is fluidically arranged between a coolant heating inlet and a coolant heating outlet, a coolant chilling loop with a conduit portion being thermally coupled to an evaporator of the heat pump unit being configured to selectively chill the coolant, wherein the conduit portion is fluidically arranged between a coolant chilling inlet and a coolant chilling outlet, wherein the first inlet, the second inlet, the coolant heating inlet, the coolant chilling inlet, the first outlet, the second outlet, the coolant heating outlet, and the coolant chilling outlet are coupled to a valve unit, wherein the valve unit is configured to selectively fluidically connect or fluidically disconnect at least one of the coolant heating loop and the coolant chilling loop to at least one of the first coolant loop and the second coolant loop, characterized in that the first coolant loop and the second coolant loop are coupled via two inter loop connection lines (122, 124). a first coolant loop with a first heat exchanger being configured to exchange heat with a first part of the vehicle and being arranged fluidically between a first inlet and a first outlet, a second coolant loop with a second heat exchanger being configured to exchange heat with a second part of the vehicle and being arranged fluidically between a second inlet and a second outlet, a coolant heating loop with a conduit portion being thermally coupled to a condenser of a heat pump unit being configured to selectively heat the coolant, wherein the conduit portion is fluidically arranged between a coolant heating inlet and a coolant heating outlet, a coolant chilling loop with a conduit portion being thermally coupled to an evaporator of the heat pump unit being configured to selectively chill the coolant, wherein the conduit portion is fluidically arranged between a coolant chilling inlet and a coolant chilling outlet, wherein the first inlet, the second inlet, the coolant heating inlet, the coolant chilling inlet, the first outlet, the second outlet, the coolant heating outlet, and the coolant chilling outlet are coupled to a valve unit, wherein the valve unit is configured to selectively fluidically connect or fluidically disconnect at least one of the coolant heating loop and the coolant chilling loop to at least one of the first coolant loop and the second coolant loop, characterized in that the first coolant loop and the second coolant loop are coupled via two inter loop connection lines (122, 124).
A device for loading an implant into a delivery system, the device comprising a guide cap, a guider and a guiding tube, wherein: the guide cap has a conical section and a straight or conical tube in communication with a small open end of the conical section, the conical section having a large open end that flares outward and thereby forms a flange; the guider has a circumferential wall (9, 10) tapered along an axis of the guider and thus forms a large open end at a first edge and a small open end at a second edge of the circumferential wall, the small open end of the guider having a diameter greater than a diameter of a free end of the straight or conical tube of the guide cap; the guide cap and the guider are so sized that the flange is able to cover the large open end of the guider, with the free end of the straight or conical tube protruding from the small open end of the guider; and the guiding tube is a round tube with a first and a second open end, the first open end having a diameter greater than the diameter of the small open end of the conical section of the guide cap and smaller than the diameter of the small open end of the guider. the guide cap has a conical section and a straight or conical tube in communication with a small open end of the conical section, the conical section having a large open end that flares outward and thereby forms a flange; the guider has a circumferential wall (9, 10) tapered along an axis of the guider and thus forms a large open end at a first edge and a small open end at a second edge of the circumferential wall, the small open end of the guider having a diameter greater than a diameter of a free end of the straight or conical tube of the guide cap; the guide cap and the guider are so sized that the flange is able to cover the large open end of the guider, with the free end of the straight or conical tube protruding from the small open end of the guider; and the guiding tube is a round tube with a first and a second open end, the first open end having a diameter greater than the diameter of the small open end of the conical section of the guide cap and smaller than the diameter of the small open end of the guider.
A mobile air conditioner with illumination (50, 150, 250), comprising: a base pan (54, 154, 254), an air shroud (52, 152, 252) engaging said base pan (54, 154, 254); a plurality of ventilation holes (56, 58, 156, 158, 256, 258) in at least one of said base pan (54, 154, 254) or said air shroud (52, 152, 252); a luminaire disposed within one of said base pan (54, 154, 254) or said air shroud (52, 152, 252), said luminaire emitting light through at least some of said plurality of ventilation holes (56, 58, 156, 158, 256, 258). a base pan (54, 154, 254), an air shroud (52, 152, 252) engaging said base pan (54, 154, 254); a plurality of ventilation holes (56, 58, 156, 158, 256, 258) in at least one of said base pan (54, 154, 254) or said air shroud (52, 152, 252); a luminaire disposed within one of said base pan (54, 154, 254) or said air shroud (52, 152, 252), said luminaire emitting light through at least some of said plurality of ventilation holes (56, 58, 156, 158, 256, 258).
A pharmaceutical composition comprising an active substance selected from nicotinic acid; nicotinamide; tryptophan; nicotinic acid esters; nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide phosphate (NADP); an intermediate in the biosynthesis of NAD or NADP selected from the group consisting of N-formylkynurenine, L-kynurenine, 3-hydroxy-L-kynurenine, 3-hydroxyanthranilate, 2-amino-3-carboxymuconate semialdehyde, quinolinate, and beta-nicotinate D-ribonucleotide; a tryptophan dipeptide; or a combination thereof, wherein the pharmaceutical composition releases the active substance for topical efficacy in the terminal ileum, the colon or both, where the intestinal microbiota to be modified are located.
A system for monitoring intra-fraction motions of a patient in connection with treatment of treatment volumes such as cancer tumors of said patient in a radiation therapy system, which radiation therapy system comprises an external beam radiation therapy unit having a radiation focus point and a patient positioning unit for positioning a treatment volume in a patient in relation to said focus point in the radiation therapy unit, said system comprising: a patient fixation arrangement for fixation of said patient during treatment; at least one patient marker arranged to be attached to the nose of the patient such that movement of the patient marker indicates movement of the head; at least one reference marker arranged to be positioned in a defined position relative to the patient fixation arrangement; an optical tracking system arranged in a position such that images of the at least one patient marker, when said at least one patient marker is provided on the nose of the patient, and of the at least one reference marker can be captured, said position of said optical tracking system being fixed relative to the at least one reference marker; and a processing module configured to determine a position of the at least one patient marker relative to the coordinate system established by the at least one reference marker based on images captured by the optical tracking system, wherein changes in said position provides information if the patient or a part of said patient has moved relative to said patient fixation arrangement, wherein the processing module is configured to provide an interrupting signal instructing the radiation therapy system to interrupt the treatment if a motion change exceeding a predetermined limit and/or lasting at least a predetermined period of time is detected. a patient fixation arrangement for fixation of said patient during treatment; at least one patient marker arranged to be attached to the nose of the patient such that movement of the patient marker indicates movement of the head; at least one reference marker arranged to be positioned in a defined position relative to the patient fixation arrangement; an optical tracking system arranged in a position such that images of the at least one patient marker, when said at least one patient marker is provided on the nose of the patient, and of the at least one reference marker can be captured, said position of said optical tracking system being fixed relative to the at least one reference marker; and a processing module configured to determine a position of the at least one patient marker relative to the coordinate system established by the at least one reference marker based on images captured by the optical tracking system, wherein changes in said position provides information if the patient or a part of said patient has moved relative to said patient fixation arrangement, wherein the processing module is configured to provide an interrupting signal instructing the radiation therapy system to interrupt the treatment if a motion change exceeding a predetermined limit and/or lasting at least a predetermined period of time is detected.
An array substrate, comprising a plurality of pixel units formed on a base substrate, a thin film transistor and a pixel electrode, a passivation layer and a common electrode sequentially formed on the base substrate being provided in the pixel unit, the pixel electrode being connected with a drain electrode of the thin film transistor, wherein, a via hole located above the pixel electrode is further provided in at least one of the pixel units, the via hole penetrates through the common electrode and the passivation layer, a bottom of the via hole is in contact with a conductive surface electrically connected with a portion of the pixel electrode, a test pattern electrically connected with the pixel electrode is further disposed in the at least one of the pixel units, and the conductive surface is a surface of the test pattern, characterized in that the test pattern is disposed between the passivation layer and the pixel electrode, and is in direct contact with the passivation layer and the pixel electrode.
A skin or hair washing composition, comprising the following components, and: a compound represented by formula: R 1 O- n -R 2 wherein R 1 represents a straight-chained or branched alkyl group or alkenyl group having 8 to 10 carbon atoms; AO represents an alkyleneoxy group having 2 to 4 carbon atoms; n, the average number of added moles, represents a number from 0.5 to less than 4.0; and R 2 represents a hydrogen atom or a methyl group; a surfactant other than the component; and a cationic polymer, wherein the weight ratio of the component and the component, /, is from 0.5 to 60. a compound represented by formula: R 1 O- n -R 2 wherein R 1 represents a straight-chained or branched alkyl group or alkenyl group having 8 to 10 carbon atoms; AO represents an alkyleneoxy group having 2 to 4 carbon atoms; n, the average number of added moles, represents a number from 0.5 to less than 4.0; and R 2 represents a hydrogen atom or a methyl group; a surfactant other than the component; and a cationic polymer,
An ophthalmic composition comprising a physiologically effective amount of an androgen which is testosterone and castor oil wherein said composition is suitable for topical administration to an eye.
N-(2-(6-fluoro-1H-indol-3-yl)ethyl)-3-(2,2,3,3-tetrafluoropropoxy) benzylamine (idalopirdine) or a pharmaceutically acceptable salt thereof and an acetylcholinesterase inhibitor selected from the group consisting of donepezil and rivastigmine for use in the treatment Parkinson's disease, wherein the treatment of Parkinson's disease consist of reducing falls in a patient with Parkinson's disease.
A digital security system comprising: abdominal pressure signal acquiring means for acquiring an abdominal pressure signal from an abdominal pressure sensor for detecting an abdominal pressure of personnel and for acquiring a respiration signal from a respiration sensor for detecting breathing of said personnel to which these sensors are fitted; abdominal pressure signal extracting means for subtracting the respiration signal component from the acquired abdominal pressure signal to extract an abdominal pressure signal with suppressed influence of respiration; abnormality determining means for determining whether it is abnormality based on the abdominal pressure signal extracted by the abdominal pressure signal extracting means; and control means for reporting an abnormal situation according to the abnormality determination result by the abnormality determining means. abdominal pressure signal acquiring means for acquiring an abdominal pressure signal from an abdominal pressure sensor for detecting an abdominal pressure of personnel and for acquiring a respiration signal from a respiration sensor for detecting breathing of said personnel to which these sensors are fitted; abdominal pressure signal extracting means for subtracting the respiration signal component from the acquired abdominal pressure signal to extract an abdominal pressure signal with suppressed influence of respiration; abnormality determining means for determining whether it is abnormality based on the abdominal pressure signal extracted by the abdominal pressure signal extracting means; and control means for reporting an abnormal situation according to the abnormality determination result by the abnormality determining means.