mhurhangee/ep-ind-claims huggingface dataset:
A method for measuring cell-mediated immune response activity, said method comprising: (a) providing an incubation composition by contacting a sample comprising immune cells capable of producing immune effector molecules following stimulation by a peptide antigen with at least one peptide antigen having a length selected from 5 to 100 amino acids and with at least one non-reducing sugar capable of increasing the interferon-gamma response of immune cells that respond to the antigen; and (b) detecting the presence or level of at least one immune effector molecule, wherein detecting the presence or level of at least one immune effector molecule comprises detecting the presence or level of interferon-gamma (INF-gamma) and/or an immune effector molecule whose production is induced or enhanced by interferon-gamma. (a) providing an incubation composition by contacting a sample comprising immune cells capable of producing immune effector molecules following stimulation by a peptide antigen with at least one peptide antigen having a length selected from 5 to 100 amino acids and with at least one non-reducing sugar capable of increasing the interferon-gamma response of immune cells that respond to the antigen; and (b) detecting the presence or level of at least one immune effector molecule, wherein detecting the presence or level of at least one immune effector molecule comprises detecting the presence or level of interferon-gamma (INF-gamma) and/or an immune effector molecule whose production is induced or enhanced by interferon-gamma.
A mask handling module for aligning a mask to a substrate, comprising: a substrate carrier for carrying at least one substrate; a mask carrier for carrying at least two masks, wherein the mask carrier comprises at least two mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) each being adapted to carry a mask; a mask carrier positioning device having at least an actuator configured for moving the mask carrier relative to the substrate carrier, wherein the actuator is adapted to bring at least one of the at least two masks into contact with one of the at least one substrate, wherein the mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) are arranged so that the masks carried on the mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) can be positioned on the mask carrier in respective planes forming an angle (α) in the range from 0.01° to 30° with respect to each other so that only one of the at least two masks can be aligned to one of the at least one substrate, wherein at least parts of the mask handling module are configured to operate under vacuum conditions, and wherein the substrate carrier and the mask carrier are arranged so that the at least one substrate and the at least two masks can be held in substantially vertical positions. a substrate carrier for carrying at least one substrate; a mask carrier for carrying at least two masks, wherein the mask carrier comprises at least two mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) each being adapted to carry a mask; a mask carrier positioning device having at least an actuator configured for moving the mask carrier relative to the substrate carrier, wherein the actuator is adapted to bring at least one of the at least two masks into contact with one of the at least one substrate, wherein the mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) are arranged so that the masks carried on the mask carrier sections (31, 32; 301, 302, 303; 304, 305, 306, 307) can be positioned on the mask carrier in respective planes forming an angle (α) in the range from 0.01° to 30° with respect to each other so that only one of the at least two masks can be aligned to one of the at least one substrate, wherein at least parts of the mask handling module are configured to operate under vacuum conditions, and wherein the substrate carrier and the mask carrier are arranged so that the at least one substrate and the at least two masks can be held in substantially vertical positions.
A polar modifier system for making block copolymers of vinyl aromatic monomers and conjugated diene monomers by anionic polymerization using an organolithium initiator, comprising: (a) one or more of the chemicals selected from the group consisting of ditetrahydrofurfurylpropane, ethyltetrahydrofurfuryl ether, N,N,N',N'-tetramethyl ethylenediamine and tetrahydrofurfuryl-N,N-dimethylamine; (b) bis[2-(N,N-dimethylamino)ethyl] ether; and (c) a sodium alkoxide compound. (a) one or more of the chemicals selected from the group consisting of ditetrahydrofurfurylpropane, ethyltetrahydrofurfuryl ether, N,N,N',N'-tetramethyl ethylenediamine and tetrahydrofurfuryl-N,N-dimethylamine; (b) bis[2-(N,N-dimethylamino)ethyl] ether; and (c) a sodium alkoxide compound.
A plastic moulding for a moulding arrangement having a housing, stepped due to the formation of a step, for another plastic moulding of the moulding arrangement, wherein the stepped housing is formed within a moulding body of the plastic moulding, which moulding body consists of a weldable material in at least some areas, characterised in that on the moulding body a contact element is arranged, consisting at least partly of an electrically conductive material and limiting a recess of the moulding body adjoining the housing in at least some areas, wherein the contact element includes a protrusion arranged in the recess and projecting towards the housing up to an inner edge of the step.
A recombination system which comprises, in a plant cell or a plant organism, I) a transgenic recombination construct inserted into the chromosomal DNA of a plant cell or of a plant organism comprising a sequence composed, in the 5'/3'-direction, of a1) a first homology sequence A and b1) at least one recognition sequence for the targeted induction of DNA double-strand breaks and c) an expression cassette as further nucleic acid sequence and a2) a second homology sequence B, the homology sequences A and B having a sufficient length and sufficient homology in order to ensure homologous recombination between the homology sequences A and B, and said expression cassette and said recognistion sequences(s) for the targeted induction of DNA double-strand breaks being removed from the chromosomal DNA as a result of homologous recombination between A and B, together with II) an enzyme suitable for inducing DNA double-strand breaks at the recognition sequences for the targeted induction of DNA double-strand breaks or a nucleic acid sequence encoding an enzyme suitable for inducing DNA double-strand breaks at the recognition sequences, and the enzyme suitable for inducing DNA double-strand breaks is selected from the group consisting of homing endonucleases, group II intron endonucleases, recombinases, transposases and chimeric nucleases. I) a transgenic recombination construct inserted into the chromosomal DNA of a plant cell or of a plant organism comprising a sequence composed, in the 5'/3'-direction, of a1) a first homology sequence A and b1) at least one recognition sequence for the targeted induction of DNA double-strand breaks and c) an expression cassette as further nucleic acid sequence and a2) a second homology sequence B, the homology sequences A and B having a sufficient length and sufficient homology in order to ensure homologous recombination between the homology sequences A and B, and said expression cassette and said recognistion sequences(s) for the targeted induction of DNA double-strand breaks being removed from the chromosomal DNA as a result of homologous recombination between A and B, together with a1) a first homology sequence A and b1) at least one recognition sequence for the targeted induction of DNA double-strand breaks and c) an expression cassette as further nucleic acid sequence and a2) a second homology sequence B, the homology sequences A and B having a sufficient length and sufficient homology in order to ensure homologous recombination between the homology sequences A and B, II) an enzyme suitable for inducing DNA double-strand breaks at the recognition sequences for the targeted induction of DNA double-strand breaks or a nucleic acid sequence encoding an enzyme suitable for inducing DNA double-strand breaks at the recognition sequences, and the enzyme suitable for inducing DNA double-strand breaks is selected from the group consisting of homing endonucleases, group II intron endonucleases, recombinases, transposases and chimeric nucleases.
A syringe assembly connectable to an injector comprising a syringe interface and a drive member, comprising: a syringe portion comprising a barrel section to contain fluid to be pressurized and an outlet in fluid connection with the barrel section; and an adapter formed separately from the syringe portion and comprising a plurality of sections, at least two sections (210, 250) of the plurality of sections being engageable to connect the adapter to the syringe portion, and a mounting mechanism (242a, 242b) adapted to be connected to the injector syringe interface, characterized in that the at least two sections (210, 250) are attachable via a permanent snap fit to non-removably connect the adapter to the syringe portion. a syringe portion comprising a barrel section to contain fluid to be pressurized and an outlet in fluid connection with the barrel section; and an adapter formed separately from the syringe portion and comprising a plurality of sections, at least two sections (210, 250) of the plurality of sections being engageable to connect the adapter to the syringe portion, and a mounting mechanism (242a, 242b) adapted to be connected to the injector syringe interface, characterized in that the at least two sections (210, 250) are attachable via a permanent snap fit to non-removably connect the adapter to the syringe portion.
Method for manufacturing panels having a decorative surface, wherein said panels at least comprise a substrate and a top layer, wherein said top layer comprises a paper layer having a printed pattern, wherein said method at least comprises the steps of - providing said paper layer with thermosetting resin, - providing said resin provided paper layer with at least a portion of said printed pattern, and - applying a further resin layer above the printed pattern after printing, wherein for providing said printed pattern use is made of pigment containing inks deposited on said resin provided paper layer by means of a digital inkjet printer, characterized in that the printed pattern is essentially made up of such pigment containing inks and covers 80 percent or more of the surface of said resin provided paper layer, and in that the dry weight of the total volume of said pigment containing inks deposited on said resin provided paper layer is lower than 9 grams per square meter, wherein for said pigment containing ink use is made of a water based ink. - providing said paper layer with thermosetting resin, - providing said resin provided paper layer with at least a portion of said printed pattern, and - applying a further resin layer above the printed pattern after printing,
A multi-mode controller for a switching mode power supply that includes a transformer having a primary winding and a secondary winding to supply power to a load and a feedback circuit that generates a feedback signal that varies in relation to the load on the secondary winding, the multi-mode controller comprising: a switching circuit to be coupled to the primary winding to control current flow through the primary winding; a frequency control circuit to control a switching frequency of the switching circuit; and a current limiting circuit to limit current flow through the primary winding by causing the switching circuit to suspend current flow through the primary winding when the current reaches a peak current limit that is set based on the feedback signal; characterized in that the switching frequency is based on the feedback signal; wherein during at least one mode, the switching frequency (fs) decreases as the load becomes lighter; and wherein during at least one mode, the peak current limit (PEAK CURRENT) decreases as the load becomes lighter. a switching circuit to be coupled to the primary winding to control current flow through the primary winding; a frequency control circuit to control a switching frequency of the switching circuit; and a current limiting circuit to limit current flow through the primary winding by causing the switching circuit to suspend current flow through the primary winding when the current reaches a peak current limit that is set based on the feedback signal; characterized in that the switching frequency is based on the feedback signal; wherein during at least one mode, the switching frequency (fs) decreases as the load becomes lighter; and wherein during at least one mode, the peak current limit (PEAK CURRENT) decreases as the load becomes lighter.
A method of processing immune cells, comprising: (a) tagmenting accessible genomic deoxyribonucleic acid (gDNA) in a nucleus in a plurality of said immune cells to produce a plurality of tagged gDNA fragments in a tagmentation reaction; (b) adding a primer, reverse transcriptase, and dNTPs to the plurality of immune cells to reverse transcribe a plurality of mRNA molecules in the plurality of immune cells to produce complimentary DNA (cDNA) molecules, wherein said cDNA molecules comprise sequences that correspond to a V J region of a genome of said immune cells; (c) sequencing the cDNA corresponding to the V J region of the genome of said immune cells and/or the sequences corresponding to said tagged gDNA fragments to generate a plurality of sequencing reads; and (d) mapping a correlation between accessible gDNA and the sequences that correspond to the V J region from one or more sequencing reads of the tagged gDNA fragments, or amplicons thereof, and/or one or more sequencing reads of the cDNA molecules, or amplicons thereof, wherein the method comprises lysing said immune cells, wherein each of said tagged gDNA fragments comprises one or more adapters, wherein the method comprises capturing one or more of said immune cells in a partition, and wherein the method comprises identifying an epigenomic signature or map of one or more of said immune cells. (a) tagmenting accessible genomic deoxyribonucleic acid (gDNA) in a nucleus in a plurality of said immune cells to produce a plurality of tagged gDNA fragments in a tagmentation reaction; (b) adding a primer, reverse transcriptase, and dNTPs to the plurality of immune cells to reverse transcribe a plurality of mRNA molecules in the plurality of immune cells to produce complimentary DNA (cDNA) molecules, wherein said cDNA molecules comprise sequences that correspond to a V J region of a genome of said immune cells; (c) sequencing the cDNA corresponding to the V J region of the genome of said immune cells and/or the sequences corresponding to said tagged gDNA fragments to generate a plurality of sequencing reads; and (d) mapping a correlation between accessible gDNA and the sequences that correspond to the V J region from one or more sequencing reads of the tagged gDNA fragments, or amplicons thereof, and/or one or more sequencing reads of the cDNA molecules, or amplicons thereof, wherein the method comprises lysing said immune cells, wherein each of said tagged gDNA fragments comprises one or more adapters, wherein the method comprises capturing one or more of said immune cells in a partition, and wherein the method comprises identifying an epigenomic signature or map of one or more of said immune cells. wherein the method comprises lysing said immune cells, wherein each of said tagged gDNA fragments comprises one or more adapters, wherein the method comprises capturing one or more of said immune cells in a partition, and wherein the method comprises identifying an epigenomic signature or map of one or more of said immune cells.
Vented extruder for the devolatilization of a polymer material, encompassing at least one drive, at least one extruder barrel, at least one rotatably driven extruder screw mounted in the extruder barrel, at least one material feed, at least one extrudate outlet, at least one vent zone, at least one gas outlet, and at least one condensation chamber provided immediately downstream of the gas output or connected to the gas output by way of pipelines, the drive has been provided in the region of that end of the extruder screw that is downstream in relation to the direction of conveying of the polymer, characterized in that the vent zone is formed via a section of the extruder barrel with increased internal diameter, the material feed has been provided in the region of the vent zone, and at least a portion of the gas stream arising can be taken off at that end of the extruder barrel that is upstream in relation to the direction of conveying of the polymer material and of the material feed, and opens there directly into the condensation chamber.
A composition for reducing emissions, carbon deposits and fuel consumption at liquid hydrocarbon fuels combustion, characterized in that it contains from 80 to 90 percent by weight of Ferrocen and the rest is composed of Behenyl alcohol and one or more components selected from a group consisting of hydrogenated cottonseed oil and magnesium stearate, wherein each of the components Behenyl alcohol, hydrogenated cottonseed oil and magnesium stearate is present in the mixture in the maximum quantity of 10 % by weight.
Battery pack for supplying an electrically driven treatment apparatus with an electric driving power, the battery pack comprising: - a stack limiting structure, - a plurality of pouch cells, wherein the pouch cells are disposed in a stack, wherein the stack is disposed within the stack limiting structure, - an outer temperature sensor, wherein the outer temperature sensor is disposed and configured for measuring an outer temperature of the stack outside the stack at an edge (20R, 10R) of the stack or the stack limiting structure or outside the stack limiting structure, and - a control device, wherein the control device is configured for comparison of the measured outer temperature or a quantity based on the measured outer temperature to at least one temperature comparative value (T37G), wherein the at least one temperature comparative value (T37G) is a function of at least one of the pouch cells, and wherein the control device is configured for controlling the battery pack in response to a result of the comparison, and - wherein the control device is configured for controlling the output of the electric driving power and/or an input of electric charging power and is disposed on a side of the stack, and - wherein the outer temperature sensor is disposed on an averted side of the stack. - a stack limiting structure, - a plurality of pouch cells, wherein the pouch cells are disposed in a stack, wherein the stack is disposed within the stack limiting structure, - an outer temperature sensor, wherein the outer temperature sensor is disposed and configured for measuring an outer temperature of the stack outside the stack at an edge (20R, 10R) of the stack or the stack limiting structure or outside the stack limiting structure, and - a control device, wherein the control device is configured for comparison of the measured outer temperature or a quantity based on the measured outer temperature to at least one temperature comparative value (T37G), wherein the at least one temperature comparative value (T37G) is a function of at least one of the pouch cells, and wherein the control device is configured for controlling the battery pack in response to a result of the comparison, and - wherein the control device is configured for controlling the output of the electric driving power and/or an input of electric charging power and is disposed on a side of the stack, and - wherein the outer temperature sensor is disposed on an averted side of the stack.
A cold/hot water supply apparatus comprising: a refrigerant circuit including a compressor, a first heat exchanger, expansion means and a second heat exchanger which are annularly connected to one another and through which refrigerant flows; a fluid circuit including the first heat exchanger and a third heat exchanger which are annularly connected to each other and through which fluid flows; a heat accumulator tank in which water is stored; a first switching pipe which is connected to the third heat exchanger in parallel, and which exchanges heat between the fluid and water in the heat accumulator tank; and a control apparatus which switches between a flow of the fluid to the third heat exchanger and a flow of the fluid to the heat accumulator tank; in which the cold/hot water supply apparatus has a heat-accumulation operation mode and a cooling operation mode, in the heat-accumulation operation mode, the fluid flows to the first switching pipe, thereby heating the water in the heat accumulator tank, and in the cooling operation mode, the fluid flows to the third heat exchanger, thereby absorbing heat in air, wherein the cold/hot water supply apparatus also includes: a temperature sensor which detects temperature of the fluid; and characterized by a second switching pipe which is connected to the third heat exchanger in parallel and which is connected to the first switching pipe in parallel, the fluid flowing through the second switching pipe; and when the cooling operation mode is changed to the heat-accumulation operation mode, the control apparatus determines whether the fluid which flows out of the first heat exchanger should be made to flow to the second switching pipe or to the first switching pipe based on temperature of the fluid detected by the temperature sensor.
Pneumatic vehicle tyre of a radial type of construction for commercial vehicles comprising a four-ply breaker belt with a first, a second, a third and a fourth belt ply (7, 8, 9, 10), wherein the first belt ply is arranged radially on the inside and the last belt ply is arranged as the radially outermost belt ply of the breaker belt, wherein each belt ply (7, 8, 9, 10) contains steel cords as reinforcing elements, which respectively run parallel to one another and are inclined with respect to the circumferential direction of the tyre, wherein the fourth belt ply has the smallest width of all the plies, wherein the second and third belt plies (8, 9) are load-bearing belt plies, the steel cords of which are inclined oppositely with respect to the circumferential direction of the tyre, and wherein arranged between the second and third belt plies (8, 9) in the region of the belt edges (11, 12) there is a rubber profile, which runs around the circumference of the tyre and has the function of a so-called belt pad, characterized in that the rubber profile is arranged in such a way that, measured from the edge of the third belt ply, it is made to extend axially inwards by less than 17 mm and in that it is made to extend axially outwards in such a way that it completely covers the edge of the second belt ply in the axially outward direction.