A compound of Formula I-A: or a pharmaceutically acceptable salt thereof, wherein W 1 is CR 5, W 2 is CR 6, W 3 is CR 7, W 4 is CR 8; R 1 is - n -R 1'; L is -S-, -N(R 2)-, -C(R 3) 2 -, or -O-; n is 0 or 1; R 1' is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR'R" wherein R' and R" are taken together with nitrogen to form a cyclic moiety; R 4, R 5, R 6, R 7 and R 8 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR'R" wherein R' and R" are taken together with nitrogen to form a cyclic moiety; X is -(CH(R 10)) z - and z is an integer of 1, 2, 3, or 4; Y is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -N(R 9)-, -C(=O)-(CHR 10) z -, -C(=O)-, -N(R 9)-C(=O)-, -N(R 9)-C(=O)NH-, or -N(R 9)C(R 10) 2 -; each instance of R 2 and R 9 is independently hydrogen, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, heterocycloalkyl, C 2 -C 10 heteroalkyl, aryl, or heteroaryl; each instance of R 3 and R 10 is independently hydrogen, alkyl, aryl, heteroaryl or halo; and W d is or wherein each instance of R a is independently hydrogen or alkyl; R 11 is H, alkyl, halo, amino, amido, hydroxy, or alkoxy; and R 12 is H, alkyl, cyano, alkynyl, alkenyl, halo, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, amino, carboxylic acid, alkoxycarbonyl, or amido. W 1 is CR 5, W 2 is CR 6, W 3 is CR 7, W 4 is CR 8; R 1 is - n -R 1'; L is -S-, -N(R 2)-, -C(R 3) 2 -, or -O-; n is 0 or 1; R 1' is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR'R" wherein R' and R" are taken together with nitrogen to form a cyclic moiety; R 4, R 5, R 6, R 7 and R 8 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR'R" wherein R' and R" are taken together with nitrogen to form a cyclic moiety; X is -(CH(R 10)) z - and z is an integer of 1, 2, 3, or 4; Y is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -N(R 9)-, -C(=O)-(CHR 10) z -, -C(=O)-, -N(R 9)-C(=O)-, -N(R 9)-C(=O)NH-, or -N(R 9)C(R 10) 2 -; each instance of R 2 and R 9 is independently hydrogen, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, heterocycloalkyl, C 2 -C 10 heteroalkyl, aryl, or heteroaryl; each instance of R 3 and R 10 is independently hydrogen, alkyl, aryl, heteroaryl or halo; and W d is or wherein each instance of R a is independently hydrogen or alkyl; R 11 is H, alkyl, halo, amino, amido, hydroxy, or alkoxy; and R 12 is H, alkyl, cyano, alkynyl, alkenyl, halo, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, amino, carboxylic acid, alkoxycarbonyl, or amido.