A system for microbubble-enhanced treatment of target tissue, the system comprising: (i) an administration device comprising a first storage container for storing microbubbles, wherein the first storage container is connected to a plurality of channels, each having a manipulation means for changing the microbubble characteristic, and a controller configured to: (a) receive a desired characteristic of the microbubbles for treating the target tissue; (b) cause the microbubbles to be dispensed from the administration device; and (c) compare a characteristic of the dispensed microbubbles to the desired characteristic so as to validate a match therebetween; characterised in that the manipulation means is configured to apply an acoustic field to the microbubbles; OR (ii) an administration device comprising a storage container for storing microbubbles; and a controller configured to: (a) receive a desired characteristic of the microbubbles for treating the target tissue; and (b) cause substantially only the microbubbles having the desired characteristic to be administered into the target tissue, further comprising: at least one fluidic channel coupled to the storage container for delivering the microbubbles to the target tissue; and a manipulator associated with the at least one fluidic channel for changing therein the microbubble characteristic, characterised in that the manipulator comprises an ultrasound transducer for applying an acoustic field to the microbubbles in the at least one fluidic channel. (i) an administration device comprising a first storage container for storing microbubbles, wherein the first storage container is connected to a plurality of channels, each having a manipulation means for changing the microbubble characteristic, and a controller configured to: (a) receive a desired characteristic of the microbubbles for treating the target tissue; (b) cause the microbubbles to be dispensed from the administration device; and (c) compare a characteristic of the dispensed microbubbles to the desired characteristic so as to validate a match therebetween; characterised in that the manipulation means is configured to apply an acoustic field to the microbubbles; OR (a) receive a desired characteristic of the microbubbles for treating the target tissue; (b) cause the microbubbles to be dispensed from the administration device; and (c) compare a characteristic of the dispensed microbubbles to the desired (ii) an administration device comprising a storage container for storing microbubbles; and a controller configured to: (a) receive a desired characteristic of the microbubbles for treating the target tissue; and (b) cause substantially only the microbubbles having the desired characteristic to be administered into the target tissue, further comprising: at least one fluidic channel coupled to the storage container for delivering the microbubbles to the target tissue; and a manipulator associated with the at least one fluidic channel for changing therein the microbubble characteristic, characterised in that the manipulator comprises an ultrasound transducer for applying an acoustic field to the microbubbles in the at least one fluidic channel. a controller configured to: (a) receive a desired characteristic of the microbubbles for treating the target tissue; and (b) cause substantially only the microbubbles having the desired characteristic to be administered into the target tissue, (a) receive a desired characteristic of the microbubbles for treating the target tissue; and (b) cause substantially only the microbubbles having the desired characteristic to be administered into the target tissue, at least one fluidic channel coupled to the storage container for delivering the microbubbles to the target tissue; and a manipulator associated with the at least one fluidic channel for changing therein the microbubble characteristic, characterised in that the manipulator comprises an ultrasound transducer for applying an acoustic field to the microbubbles in the at least one fluidic channel.