A therapeutic medical stocking having a variable pressure profile along its length, and comprising: (a) a knitted tubular body; (b) a knitted anti-slip portion formed proximate one end of the tubular body with an inner surface adapted for residing against a wearer's skin; (c) the knitted anti-slip portion including at least first and second high friction yarns (18, 20; 38, 40; 56, 58; 76, 78; 104, 106, 108), having a coefficient of friction in relation to a predetermined standard ceramic material above 0.5, and being simultaneously knitted to form a repeat having a raised surface texture on the inner surface of the anti-slip portion, wherein one of the first and second high friction yarns is a low elasticity yarn, exhibiting less than 100% elongation under a 50 gram load on a CRE tensile tester, and further wherein at least one of the first and second high friction yarns is knitted to reside on and form the raised surface texture on the inner face of the anti-slip portion, wherein the anti-slip portion has a fabric structure (10; 30; 50; 70) that is arranged such that the surface of the stocking facing away from the wearer, in use, is principally low-friction yarns (14, 16; 34, 36, 42; 54, 74), having a coefficient of friction in relation to a predetermined standard ceramic material below 0.5, so that the high-friction yarns do not cause objectionable cling between the stocking and other clothing items worn on over the stocking, wherein the coefficient of friction is determined according to ASTM standard B 3108 - 95 using apparatus 2 of fig. 2 of the standard a wrap angle of 163,5°, a rod diameter of 8mm, a pretension of 3,0 gram; the values being calculated using the equation specified in section 11.4 of the standard. (a) a knitted tubular body; (b) a knitted anti-slip portion formed proximate one end of the tubular body with an inner surface adapted for residing against a wearer's skin; (c) the knitted anti-slip portion including at least first and second high friction yarns (18, 20; 38, 40; 56, 58; 76, 78; 104, 106, 108), having a coefficient of friction in relation to a predetermined standard ceramic material above 0.5, and being simultaneously knitted to form a repeat having a raised surface texture on the inner surface of the anti-slip portion, wherein one of the first and second high friction yarns is a low elasticity yarn, exhibiting less than 100% elongation under a 50 gram load on a CRE tensile tester, and further wherein at least one of the first and second high friction yarns is knitted to reside on and form the raised surface texture on the inner face of the anti-slip portion, wherein the anti-slip portion has a fabric structure (10; 30; 50; 70) that is arranged such that the surface of the stocking facing away from the wearer, in use, is principally low-friction yarns (14, 16; 34, 36, 42; 54, 74), having a coefficient of friction in relation to a predetermined standard ceramic material below 0.5, so that the high-friction yarns do not cause objectionable cling between the stocking and other clothing items worn on over the stocking, wherein the coefficient of friction is determined according to ASTM standard B 3108 - 95 using apparatus 2 of fig. 2 of the standard a wrap angle of 163,5°, a rod diameter of 8mm, a pretension of 3,0 gram; the values being calculated using the equation specified in section 11.4 of the standard.