mhurhangee/ep-ind-claims huggingface dataset:
A method of adapting a pharmaceutical composition comprising immunocompound pharmaceutical components for the treatment of a cancerous disease in a patient in need thereof, comprising: determining a model including: a current disease state including as factors determinations of cell count prevalences of a plurality of clonal cell types in the cancerous disease of the patient, and immunocompound pharmaceutical components having treatment effects on the disease state based on the measured partitioning of the immunocompound pharmaceutical components among the clonal cell types; calculating a composition of said immunocompound pharmaceutical components acting on the current disease state according to their measured partitioning to produce a target disease state model including as factors determinations of cell count prevalences of the plurality of clonal cell types; formulating a treatment composition for said patient based on the calculated composition; receiving results providing information about cell count prevalences of the plurality of clonal cell types in the patient after the treatment composition was administered; producing a new disease state model based on the received results; adjusting the model based on differences between the target disease state model and the new disease state model of the patient; and repeating said calculating and formulating. determining a model including: a current disease state including as factors determinations of cell count prevalences of a plurality of clonal cell types in the cancerous disease of the patient, and immunocompound pharmaceutical components having treatment effects on the disease state based on the measured partitioning of the immunocompound pharmaceutical components among the clonal cell types; calculating a composition of said immunocompound pharmaceutical components acting on the current disease state according to their measured partitioning to produce a target disease state model including as factors determinations of cell count prevalences of the plurality of clonal cell types; formulating a treatment composition for said patient based on the calculated composition; receiving results providing information about cell count prevalences of the plurality of clonal cell types in the patient after the treatment composition was administered; producing a new disease state model based on the received results; adjusting the model based on differences between the target disease state model and the new disease state model of the patient; and repeating said calculating and formulating.
A structure comprising at least two extendable panels (11, 12, 13) and a shockproof device intended to prevent said panels (11, 12, 13) from colliding when they are folded against each other, characterised in that said shockproof device comprises a one-piece element comprising two plates (26, 27) and arms (41, 42, 43, 44) connecting said two plates (26, 27), in that a first of said two plates is fixed to said first panel, in that a second of said two plates forms an abutment, against which said second panel comes into abutment, and in that said arms (41, 42, 43, 44) form a flexible element between said two plates (26, 27).
A building construction with a wall that comprises - a sandwich panel, comprising a pair of parallel metal plates (20a,b), forming opposite parallel surfaces (20a,b) of the wall, and fiber material between said metal plates (20a,b), glued to said metal plates (20a,b); - a beam, the sandwich panel hanging from said beam on fasteners that extend into said beam; wherein the fasteners extend through the sandwich panel between the parallel surfaces (20a,b) into said beam; characterized in that the wall comprises - a heat isolation layer on at least one side of the sandwich panel, over the fasteners and over an area of the panel surrounding the fasteners on that side of the panel, and in that the building construction further comprises a heat isolation element that comprises said heat isolation layer and a cover attached over the heat isolation layer, the cover serving as a mechanical coupling of the heat isolation layer directly or indirectly to said beam and/or the metal plate on said at least one side of the sandwich panel. - a sandwich panel, comprising a pair of parallel metal plates (20a,b), forming opposite parallel surfaces (20a,b) of the wall, and fiber material between said metal plates (20a,b), glued to said metal plates (20a,b); - a beam, the sandwich panel hanging from said beam on fasteners that extend into said beam; wherein the fasteners extend through the sandwich panel between the parallel surfaces (20a,b) into said beam; characterized in that the wall comprises - a heat isolation layer on at least one side of the sandwich panel, over the fasteners and over an area of the panel surrounding the fasteners on that side of the panel, and - a heat isolation layer on at least one side of the sandwich panel, over the fasteners and over an area of the panel surrounding the fasteners on that side of the panel, and in that the building construction further comprises a heat isolation element that comprises said heat isolation layer and a cover attached over the heat isolation layer, the cover serving as a mechanical coupling of the heat isolation layer directly or indirectly to said beam and/or the metal plate on said at least one side of the sandwich panel.
A fixing device comprising: - a crimping part comprising a first shank, - a nut comprising a second shank arranged in the continuity of the first shank, said second shank being provided with an internal thread and with a securing part mounted on the first shank so as to enable a radial movement of the second shank with respect to the first shank, characterized in that: - the securing part is configured with the first shank to form a stop enabling an axial movement of the second shank with respect to the first shank while at the same time limiting this axial movement so as to prevent separation of the nut and of the crimping part, - an insert is screwed into the thread of the second shank, said insert penetrating into a section of the first shank having a larger inner diameter than the outer diameter of the insert so as to enable radial movement of the second shank with respect to the first shank and to form a stop of said radial movement. - a crimping part comprising a first shank, - a nut comprising a second shank arranged in the continuity of the first shank, said second shank being provided with an internal thread and with a securing part mounted on the first shank so as to enable a radial movement of the second shank with respect to the first shank, - the securing part is configured with the first shank to form a stop enabling an axial movement of the second shank with respect to the first shank while at the same time limiting this axial movement so as to prevent separation of the nut and of the crimping part, - an insert is screwed into the thread of the second shank, said insert penetrating into a section of the first shank having a larger inner diameter than the outer diameter of the insert so as to enable radial movement of the second shank with respect to the first shank and to form a stop of said radial movement.
A method of providing cooling by a cooling system to a computer data center, comprising: providing a plurality of air-and-water radiators and one or more chillers, the chillers each having a first side in fluid communication with a chilled water loop, where heated water from the computer data center is circulated to chilled water sides of the one or more chillers and a second side in fluid communication with a condenser water loop (112, 114), where warmed return water from the condenser water side of the chiller is circulated through one or more of the plurality of air-and-water radiators; selectively proportioning the warmed return water from the computer data center into a first portion and a second portion based on a cooling load; circulating the first portion of the warmed return water coming from the computer data center through a first subset of the plurality of air-and-water radiators; circulating the second portion of the warmed return water coming from the computer data center through the chilled water loop; circulating the water in the condenser water loop through a second subset of the air-and water radiators; and circulating the first portion and the second portion of the return water to the computer data center as cooled supply water; wherein selectively proportioning further comprises proportioning the first and second subsets of the plurality of air-and-water radiators. providing a plurality of air-and-water radiators and one or more chillers, the chillers each having a first side in fluid communication with a chilled water loop, where heated water from the computer data center is circulated to chilled water sides of the one or more chillers and a second side in fluid communication with a condenser water loop (112, 114), where warmed return water from the condenser water side of the chiller is circulated through one or more of the plurality of air-and-water radiators; selectively proportioning the warmed return water from the computer data center into a first portion and a second portion based on a cooling load; circulating the first portion of the warmed return water coming from the computer data center through a first subset of the plurality of air-and-water radiators; circulating the second portion of the warmed return water coming from the computer data center through the chilled water loop; circulating the water in the condenser water loop through a second subset of the air-and water radiators; and circulating the first portion and the second portion of the return water to the computer data center as cooled supply water; wherein selectively proportioning further comprises proportioning the first and second subsets of the plurality of air-and-water radiators.
A casting core for a shroud or a blade outer air seal (BOAS) comprising: first and second end portions (202, 204); and a plurality of legs including: a plurality of first legs (210, 214, 218), each having: a first end (230, 240, 250) joining the first end portion; a main body portion; and a second end (230, 242, 252); and a plurality of second legs (212, 216, 200), each having: a first end (236, 246, 248); a main body portion; and a second end (239, 256, 254) joining the second end portion, wherein: at least one of the second legs (212, 216, 220) has: its first end (236, 246, 248) joining the first end portion; and a plurality of apertures in the main body portion; or at least one of the first legs (210, 214, 218) has: its second end (230, 242, 252) joining the second end portion; and a plurality of apertures in the main body portion. first and second end portions (202, 204); and a plurality of legs including: a plurality of first legs (210, 214, 218), each having: a first end (230, 240, 250) joining the first end portion; a main body portion; and a second end (230, 242, 252); and a plurality of second legs (212, 216, 200), each having: a first end (236, 246, 248); a main body portion; and a second end (239, 256, 254) joining the second end portion, a plurality of first legs (210, 214, 218), each having: a first end (230, 240, 250) joining the first end portion; a main body portion; and a second end (230, 242, 252); and a first end (230, 240, 250) joining the first end portion; a main body portion; and a second end (230, 242, 252); and a plurality of second legs (212, 216, 200), each having: a first end (236, 246, 248); a main body portion; and a second end (239, 256, 254) joining the second end portion, a first end (236, 246, 248); a main body portion; and a second end (239, 256, 254) joining the second end portion, at least one of the second legs (212, 216, 220) has: its first end (236, 246, 248) joining the first end portion; and a plurality of apertures in the main body portion; or at least one of the first legs (210, 214, 218) has: its second end (230, 242, 252) joining the second end portion; and a plurality of apertures in the main body portion. its first end (236, 246, 248) joining the first end portion; and a plurality of apertures in the main body portion; or at least one of the first legs (210, 214, 218) has: its second end (230, 242, 252) joining the second end portion; and a plurality of apertures in the main body portion.
A resource allocation method, comprising: • allocating, by a network-side device, a first resource block, wherein the first resource block is used to carry a positioning reference signal, and the positioning reference signal is used to perform positioning on a terminal device; • determining, by the network-side device, a first allocation mode of the first resource block, wherein the first allocation mode is configuring the positioning reference signal in all unoccupied resource elements of the first resource block; and • sending, by the network-side device, the positioning reference signal on the first resource block in the first allocation mode, or receiving, by the network-side device, the positioning reference signal on the first resource block in the first allocation mode. • allocating, by a network-side device, a first resource block, wherein the first resource block is used to carry a positioning reference signal, and the positioning reference signal is used to perform positioning on a terminal device; • determining, by the network-side device, a first allocation mode of the first resource block, wherein the first allocation mode is configuring the positioning reference signal in all unoccupied resource elements of the first resource block; and • sending, by the network-side device, the positioning reference signal on the first resource block in the first allocation mode, or receiving, by the network-side device, the positioning reference signal on the first resource block in the first allocation mode.
Method for determining isotropic stress by means of at least one Hall element, which has a plate-shaped area made of a doped semiconductor material and comprises four contacts contacting the plate-shaped area, the contacts forming corners of a quadrangle, two neighbouring corners of the quadrangle defining an edge thereof, the method comprising determining at least one van der Pauw transresistance value (R vdp1, R vdp2) in at least one van der Pauw measurement setup of the at least one Hall element, wherein the four contacts of the Hall element form contact pairs, a contact pair comprising two contacts which are neighbouring corners of the quadrangle, one contact pair being used for supplying a current and the other contact pair being used for measuring a voltage (V vdp1), a relationship between the supplied current and the measured voltage (V vdp1) defining the Van der Pauw transresistance value (R vdp1), characterized in that the method comprises determining a stress signal (V s) which depends at least on the at least one Van der Pauw transresistance value (R vdp1, R vdp2) of which at least a first Van der Pauw transresistance is measured, and of which a second Van der Pauw transresistance value is measured or determined from a transresistance offset value (R offset) and the first Van der Pauw transresistance value wherein R Offset = R vdp 2 - R vdp 1, wherein determining the stress signal (V S) is done by deriving a sheet resistance value, or sheet resistance voltage V sq, by solving the van der Pauw equation exp − π R vdp 1 R sq + exp − π R vdp 2 R sq = 1 or an approximation based on a linear combination of the at least one Van der Pauw transresistance value, wherein the sheet resistance voltage (V sq) is proportional to the sheet resistance value (R sq) and, by determining the stress signal (V s) by evaluating V S = V sq 2 + Γ 1 2 V Offset 2 + Γ 2 2 Δ V W 2 wherein Γ 1 is a constant and V offset is a voltage proportional to the transresistance offset value (R offset), and wherein Γ 2 is a constant and ΔV W is the difference voltage over a first diagonal of the contacts as a result from applying a current along the first diagonal and the voltage over a second diagonal of the contacts as a result from applying a current along the second diagonal, and determining the isotropic stress by comparing the determined stress signal (V s) with a reference function for the stress signal (V S, ref) which is obtained by a calibration procedure in function of temperature.
Heater device, in particular continuous flow heater device, having at least one gas burner for heating of flowing water according to requirement, and having at least one pilot flame supply line for the gas supply for a pilot flame of the gas burner, characterized by a shut-off unit which has at least one shut-off valve and which is intended for interrupting a feed of gas to the pilot flame supply line in dependence on at least one characteristic variable of flow of the water.
A current transformer system configured to measure a current signal, the current transformer system including: an integrated magnetic actuator component (104, 202); a bobbin that houses a primary coil, wherein the bobbin retains an upper plate and a lower plate; characterized in that the current transformer system further includes a lamination stack abutted to an end of the upper plate and to an end of the lower plate, that improves magnetic coupling between the upper plate and the lower plate, wherein the primary coil is wrapped around both the integrated magnetic actuator component and the lamination stack. an integrated magnetic actuator component (104, 202); a bobbin that houses a primary coil, wherein the bobbin retains an upper plate and a lower plate; characterized in that the current transformer system further includes a lamination stack abutted to an end of the upper plate and to an end of the lower plate, that improves magnetic coupling between the upper plate and the lower plate, wherein the primary coil is wrapped around both the integrated magnetic actuator component and the lamination stack.
A lancing device having: a housing comprising a main body portion and a forward nose portion removable and replaceable to allow loading and unloading of a lancet in use; a lancet holder movably mounted in said main body and having a forward portion for receiving a lancet in use; a lancet release element (40, 42) movable in a longitudinal direction between a rearward rest position and a forward release position, wherein movement of said lancet release element (40, 42) to its forward release position is prevented or resisted by said forward nose portion when connected to said main body portion. a housing comprising a main body portion and a forward nose portion removable and replaceable to allow loading and unloading of a lancet in use; a lancet holder movably mounted in said main body and having a forward portion for receiving a lancet in use; a lancet release element (40, 42) movable in a longitudinal direction between a rearward rest position and a forward release position, wherein movement of said lancet release element (40, 42) to its forward release position is prevented or resisted by said forward nose portion when connected to said main body portion.
A hair treatment method for curling a lock of hair using a hair holder (1, 1a, 1b, 1c) including a tubular body (2, 2a, 2b, 2c), the tubular body (2, 2a, 2b, 2c) having: a first opening located at a first end of the tubular body (2, 2a, 2b, 2c); and a second opening located at a second end of the tubular body (2, 2a, 2b, 2c), and being configured to allow a lock of hair to be inserted from the first opening toward the second opening and to be capable of being rolled up, the method comprising inserting a lock of hair into the hair holder (1, 1a, 1b, 1c), rolling up the tubular body (2, 2a, 2b, 2c) together with the lock of hair inserted in the tubular body (2, 2a, 2b, 2c), and curling the lock of hair in this wound state, characterized in that the rolling up the tubular body (2, 2a, 2b, 2c) together with the lock of hair inserted in the tubular body (2, 2a, 2b, 2c) is conducted in such a manner that the number of turns of the lock of hair is less than one. the method comprising inserting a lock of hair into the hair holder (1, 1a, 1b, 1c), rolling up the tubular body (2, 2a, 2b, 2c) together with the lock of hair inserted in the tubular body (2, 2a, 2b, 2c), and curling the lock of hair in this wound state, characterized in that the rolling up the tubular body (2, 2a, 2b, 2c) together with the lock of hair inserted in the tubular body (2, 2a, 2b, 2c) is conducted in such a manner that the number of turns of the lock of hair is less than one.
A multi-drive combined bending machine, comprising a bending component with a vertical plate provided with a bending portion, a driving component and a transmission component, wherein two ends of the transmission component are respectively connected to the bending component and the driving component so that the transmission component is capable of driving the bending component to move toward a material to be bent under the action of the driving component; and the transmission component comprises a transmission member and a mounting member arranged on the transmission member, the mounting member is connected with a connecting member fixedly connected thereto at one end, characterized in that the connecting member is sleeved with the bending component rotatable relative thereto, a thrust joint bearing comprising a spherical sliding surface in order to enable the tilting motion sleeved on the connecting member and rotatable relative to the connecting member is arranged between the mounting member and the bending component, and the bending component is capable of abutting against the thrust joint bearing, the thrust joint bearing is able to rotate according to the deformation of the vertical plate, so as to rotate relative to the connecting member under an applied force.
Door system, comprising a door leaf, a door frame, a plurality of door hinges and a protective profile, wherein the door leaf is arranged on the door frame so as to be pivotable via the door hinges, wherein the door leaf can be transferred from an open state into a closed state and vice versa by a pivoting movement, wherein the protective profile is arranged between an upper one of the door hinges and a lower one of the door hinges and at least partially covers a gap between the door leaf and the door frame in the open state of the door leaf, wherein the protective profile has a cavity, characterized in that a drive is arranged in the cavity, which drive is designed to cause the pivoting movement.