mhurhangee/ep-ind-claims huggingface dataset:
Sanitary shower head, comprising - a shower head housing having a fluid inlet, - a fluid chamber in fluid communication with the fluid inlet in the shower head housing, and - a jet disk including at least one jet discharge opening, which disk is arranged on a shower jet discharge side of the shower head housing and is held on a circumferential side on the shower head housing and confines the fluid chamber on a discharge side, - wherein the jet disk is an elastic disk which is capable of being elastically deformed by a fluid pressure in the fluid chamber from an initial contour to a final contour, characterized in that - the fluid chamber is confined by a boundary surface on a side located opposite the jet disk, which boundary surface extends in conformity with the initial contour of the jet disk at least in a partial surface region (TB, TB1), and/or - the initial contour of the jet disk extends inwardly curved in direction towards the fluid chamber. - a shower head housing having a fluid inlet, - a fluid chamber in fluid communication with the fluid inlet in the shower head housing, and - a jet disk including at least one jet discharge opening, which disk is arranged on a shower jet discharge side of the shower head housing and is held on a circumferential side on the shower head housing and confines the fluid chamber on a discharge side, - wherein the jet disk is an elastic disk which is capable of being elastically deformed by a fluid pressure in the fluid chamber from an initial contour to a final contour, - the fluid chamber is confined by a boundary surface on a side located opposite the jet disk, which boundary surface extends in conformity with the initial contour of the jet disk at least in a partial surface region (TB, TB1), and/or - the initial contour of the jet disk extends inwardly curved in direction towards the fluid chamber.
A cytotoxic cell-targeting molecule comprising: i) a heterologous, binding region capable of specifically binding an extracellular target biomolecule, ii) a Shiga toxin effector polypeptide comprising (a) a Shiga toxin A1 fragment region having a carboxy terminus and (b) a disrupted furin-cleavage motif at the carboxy terminus of the A1 fragment region, and iii) a molecular moiety having a mass of at least 1.5 kDa and associated with the carboxy terminus of the Shiga toxin effector polypeptide; wherein the cytotoxic cell-targeting molecule does not comprise a compensatory furin-cleavage site; and wherein the cell-targeting molecule is capable of exhibiting improved stability and/or improved in vivo tolerability compared to a second cytotoxic cell-targeting molecule consisting of the cytotoxic cell-targeting molecule except for the Shiga toxin effector polypeptide consists of a wild-type, Shiga toxin A1 polypeptide. i) a heterologous, binding region capable of specifically binding an extracellular target biomolecule, ii) a Shiga toxin effector polypeptide comprising (a) a Shiga toxin A1 fragment region having a carboxy terminus and (b) a disrupted furin-cleavage motif at the carboxy terminus of the A1 fragment region, and (a) a Shiga toxin A1 fragment region having a carboxy terminus and (b) a disrupted furin-cleavage motif at the carboxy terminus of the A1 fragment region, and iii) a molecular moiety having a mass of at least 1.5 kDa and associated with the carboxy terminus of the Shiga toxin effector polypeptide; improved stability and/or improved in vivo tolerability
A first router in a hierarchical domain having egress routers in a plurality of levels, comprising: a transceiver configured to receive a multicast packet, wherein the first router multicasts at most a number of copies of the multicast packet that is equal to a number of levels in the hierarchical domain; a processor configured to generate a first copy of the multicast packet for transmission to a first subset of the egress routers in a local group associated with the first router based on a first bitstring that identifies the first subset of the egress routers and a second copy of the multicast packet for transmission to at least one second router based on a second bitstring that identifies the at least one second router, wherein the at least one second router is disposed between the first router and a second subset of the egress routers. a transceiver configured to receive a multicast packet, wherein the first router multicasts at most a number of copies of the multicast packet that is equal to a number of levels in the hierarchical domain; a processor configured to generate a first copy of the multicast packet for transmission to a first subset of the egress routers in a local group associated with the first router based on a first bitstring that identifies the first subset of the egress routers and a second copy of the multicast packet for transmission to at least one second router based on a second bitstring that identifies the at least one second router, wherein the at least one second router is disposed between the first router and a second subset of the egress routers.
A foamed tea beverage composed of: - a mixture of liquid and bubbles, - a foam head above the mixture of liquid and bubbles, the beverage being deprived of any creamer, lipid or thickener agent, and being generated from the combination of water, a powdered tea composition comprising a tea extract powder, and a food-grade acid, characterized in that said combination of water, tea, and acid, is performed under pressure. - a mixture of liquid and bubbles, - a foam head above the mixture of liquid and bubbles,
Connecting profile for components adjoining plaster, in particular for window or door frames, having a two-part base leg (11, 12), the inner leg of which has fastening means on the component side and is connected to an outer leg aligned parallel to the inner leg, wherein the outer leg has a plastering leg projecting substantially perpendicularly thereto and a plastering strip with a plaster removal edge, wherein an elastic sealing strip is arranged between the inner leg and the outer leg, which is suitable to at least partly compensate component movements between the plaster and the component, and that the inner leg, which is fixed to the component with an adhesive layer or an adhesive tape, has a sealing lip resting against the component, characterised in that a sealing flange projecting away from the component is arranged on the inner leg, the end region of which rests in a sliding and sealing manner against parts of the outer leg of the plastering leg and/or the plastering strip, and in that the sealing lip and the sealing flange are produced as an integral extrudate and are fastened to the inner leg by means of co-extrusion.
A method for manufacturing an electric winding of an electromagnetic induction apparatus, comprising the following steps: - providing a conductor structure including a conductor element extending longitudinally along a main extension direction and a plurality of spacer elements (3A, 3B) made of electrically insulating material, said spacer elements being fixed to at least a lateral surface (2A, 2B) of said conductor element and being arranged spaced one from another along said lateral surface (2A, 2B); - forming an electric winding by means of said conductor structure, said electric winding extending axially along a winding direction and having a plurality of turns arranged around said winding direction, wherein each turn of said electric winding is formed by a corresponding longitudinal portion (2E, 2F) of said conductor element; wherein said spacer elements (3A, 3B) are interposed between adjacent turns of said electric winding at opposite sides (101A, 101B) of said turns; characterised in that, for at least a turn of said electric winding, each spacer element (3A, 3B) at one side of said turn is partially overlapped with two spacer elements (3A, 3B) at the opposite side of said turn, the overlapping direction is parallel to the winding direction. - providing a conductor structure including a conductor element extending longitudinally along a main extension direction and a plurality of spacer elements (3A, 3B) made of electrically insulating material, said spacer elements being fixed to at least a lateral surface (2A, 2B) of said conductor element and being arranged spaced one from another along said lateral surface (2A, 2B); - forming an electric winding by means of said conductor structure, said electric winding extending axially along a winding direction and having a plurality of turns arranged around said winding direction, wherein each turn of said electric winding is formed by a corresponding longitudinal portion (2E, 2F) of said conductor element; wherein said spacer elements (3A, 3B) are interposed between adjacent turns of said electric winding at opposite sides (101A, 101B) of said turns;
An apparatus (100, 800) for assessing a risk of an exacerbation and/or hospitalization of a subject, the apparatus (100, 800) comprising: an input unit (110, 810) for receiving time-dependent physical activity data for said subject said time-dependent physical activity data being obtained by an accelerometer; an activity data transform unit (120, 820) configured to transform said time-dependent activity data to obtain frequency-dependent activity data, a moment determination unit (130, 830) that is configured to compute a moment of said frequency-dependent activity data; and a risk assessment unit (140, 840) that is configured to assess said risk of said exacerbation and/or hospitalization of said subject based at least on said moment, wherein said moment of said frequency-dependent activity data corresponds to an integral of said frequency-dependent activity data over all frequencies, and/or wherein said moment of said frequency-dependent activity data corresponds to an integral of said frequency-dependent activity data between a first frequency and a second frequency. an input unit (110, 810) for receiving time-dependent physical activity data for said subject said time-dependent physical activity data being obtained by an accelerometer; an activity data transform unit (120, 820) configured to transform said time-dependent activity data to obtain frequency-dependent activity data, a moment determination unit (130, 830) that is configured to compute a moment of said frequency-dependent activity data; and a risk assessment unit (140, 840) that is configured to assess said risk of said exacerbation and/or hospitalization of said subject based at least on said moment, wherein said moment of said frequency-dependent activity data corresponds to an integral of said frequency-dependent activity data over all frequencies, and/or wherein said moment of said frequency-dependent activity data corresponds to an integral of said frequency-dependent activity data between a first frequency and a second frequency.
Process for the preparation of benzene derivatives of the formula; wherein R 1 and R 2, are the same or different and independently are selected from the group consisting of hydrogen, alkyl, aralkyl, -CHO, -CH 2 OR 3, -CH(OR 4)(OR 5) and -COOR 6, wherein R 3, R 4 and R 5 are the same or different and are selected from hydrogen, alkyl, aryl, alkaryl, aralkyi, alkylcarbonyl or arylcarbonyl, or wherein R 4 and R 5 together form an alkylene group and wherein R 6 is selected from hydrogen, alkyl and aryl, which process comprises: reacting a furan derivative of formula wherein R 1 and R 2 have the meanings above, with ethylene under cycloaddition reaction conditions in the presence of an acid solvent to produce the benzene derivative, wherein the acid solvent is a carboxylic acid and is present in a weight ratio acid solvent to furan derivative from 1:1 to 250:1. reacting a furan derivative of formula wherein R 1 and R 2 have the meanings above, with ethylene under cycloaddition reaction conditions in the presence of an acid solvent to produce the benzene derivative, wherein the acid solvent is a carboxylic acid and is present in a weight ratio acid solvent to furan derivative from 1:1 to 250:1.
A reel for winding a cable segment of optical fiber cable type, the reel comprising: - a winding support for supporting the cable segment; - holder means adapted to hold the cable segment wound around the winding support; - first fastener means arranged to fasten the reel to an edge of an electrical circuit card so that the reel is positioned on one side of the circuit card; - second fastener means arranged to fasten the reel flat against a face of the circuit card. - a winding support for supporting the cable segment; - holder means adapted to hold the cable segment wound around the winding support; - first fastener means arranged to fasten the reel to an edge of an electrical circuit card so that the reel is positioned on one side of the circuit card; - second fastener means arranged to fasten the reel flat against a face of the circuit card.
A method of monitoring related communication signal streams, comprising: receiving an incoming communication signal stream from a calling party to a customer service representative of the related communication signal streams; receiving an outgoing communication signal stream from the customer service representative to the calling party of the related communication signal streams; receiving control information associated with the related communication signal streams; and recording the related communication signal streams and the control information; the method being characterized by automatically analyzing, at a search and replay application, the recorded related communication signal streams at a first analysis module to determine recording details and content (27, 28) of the related communication signal streams; automatically providing the recording details and content to a second analysis module to derive statistical details and an energy envelope (31, 32) of the related communication signal streams, the second analysis module further including a speech recognition module that determines a transcript of the related communication signal streams; automatically providing a graphical output of the statistical details and energy envelope to the search and replay application; and automatically scoring the related communication signal streams against a set of predetermined criteria based on the transcript to provide an indication of a performance of the customer service representative. receiving an incoming communication signal stream from a calling party to a customer service representative of the related communication signal streams; receiving an outgoing communication signal stream from the customer service representative to the calling party of the related communication signal streams; receiving control information associated with the related communication signal streams; and recording the related communication signal streams and the control information; the method being characterized by
An oligonucleotide comprising a nucleobase sequence that has at least 90% sequence identity to: GGTTGACATC GTCTGCCTGT (SEQ ID NO: 208 or SEQ ID NO: 285) wherein C in any of the nucleobase sequences is either cytosine or 5-methylcytosine, and wherein at least one nucleotide of the oligonucleotide has a 2'-modification.
A tool for simultaneous local stress relief of each of a multiple of linear friction welds, the tool comprising: a columnar track (506A, 506B) defined along an axis, the columnar track (506A, 506B) having a helical slot; and a support structure (502, 504) engaged with the helical slot to translate and rotate a heat treat fixture portion (300A, 300B) along the axis, wherein the support structure comprises: an upper support structure engaged with the helical slot to translate and rotate an upper heat treat fixture portion along the axis; and a lower support structure engaged with the helical slot to translate and rotate a lower heat treat fixture portion along the axis, wherein the lower support structure translates and rotates opposite the upper support structure. a columnar track (506A, 506B) defined along an axis, the columnar track (506A, 506B) having a helical slot; and a support structure (502, 504) engaged with the helical slot to translate and rotate a heat treat fixture portion (300A, 300B) along the axis, wherein the support structure comprises: an upper support structure engaged with the helical slot to translate and rotate an upper heat treat fixture portion along the axis; and a lower support structure engaged with the helical slot to translate and rotate a lower heat treat fixture portion along the axis, wherein the lower support structure translates and rotates opposite the upper support structure. an upper support structure engaged with the helical slot to translate and rotate an upper heat treat fixture portion along the axis; and a lower support structure engaged with the helical slot to translate and rotate a lower heat treat fixture portion along the axis, wherein the lower support structure translates and rotates opposite the upper support structure.
Arrangement of a valve on a device, the casing of the valve being snap-fitted onto the body of the device and in which, the casing and the body have, integrated therein, means of which at least one is elastic, said means being arranged in a complementary manner in a linear engagement along a main axis, the engagement being of the male-female type and being a force fit, in the course of which the elastic means deforms and in which one of the means comprises a channel and the other means comprises a protuberance arranged so as to engage in the channel at the end of the force-fitting such that the casing of the valve is snap-fitted onto the body of the device and in which, the complementary means comprise two tubular cylindrical portions (20, 32) of which at least one is crenellated such that its merlons are elastically deformable and in which, the protuberance is an annular bead integrated into the internal face of the female tubular portion and in which the channel is an annular channel integrated into the external face of the male tubular portion.
A method of packaging a planar resonator gyroscope, comprising: mounting a plantar resonator die comprising a planar resonator and a baseplate onto a substrate to define a cavity between the substrate and the baseplate, such that the resonator is suspended in the cavity; mounting the substrate to a carrier; and securing a cap to the carrier; wherein: at least a portion of the substrate is removed to define a plurality of cantilevered sections; and the baseplate is coupled to the substrate on at least one of the plurality of cantilevered sections. mounting a plantar resonator die comprising a planar resonator and a baseplate onto a substrate to define a cavity between the substrate and the baseplate, such that the resonator is suspended in the cavity; mounting the substrate to a carrier; and securing a cap to the carrier; wherein: at least a portion of the substrate is removed to define a plurality of cantilevered sections; and the baseplate is coupled to the substrate on at least one of the plurality of cantilevered sections. at least a portion of the substrate is removed to define a plurality of cantilevered sections; and the baseplate is coupled to the substrate on at least one of the plurality of cantilevered sections.
A nucleic acid molecule encoding a chimeric antigen receptor, wherein the chimeric antigen receptor comprises: chlorotoxin or variant thereof having 1-5 amino acid modifications; a transmembrane domain selected from: a CD4 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD8 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD28 transmembrane domain or a variant thereof having 1-5 amino acid modifications, and a CD3ζ transmembrane domain or a variant thereof having 1-5 amino acid modifications; a spacer region located between the chlorotoxin or variant thereof and the transmembrane domain; a costimulatory domain selected from: a CD28 costimulatory domain or a variant thereof having 1-5 amino acid modifications, a 4-1BB costimulatory domain or a variant thereof having 1-5 amino acid modifications and an OX40 costimulatory domain or a variant thereof having 1-5 amino acid modifications; and CD3 ζ signaling domain or a variant thereof having 1-5 amino acid modifications, wherein the chlorotoxin or variant thereof enables the chimeric antigen receptor, when expressed on the surface of a T cell, to direct T cell activity to glioblastoma cells. chlorotoxin or variant thereof having 1-5 amino acid modifications; a transmembrane domain selected from: a CD4 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD8 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD28 transmembrane domain or a variant thereof having 1-5 amino acid modifications, and a CD3ζ transmembrane domain or a variant thereof having 1-5 amino acid modifications; a spacer region located between the chlorotoxin or variant thereof and the transmembrane domain; a costimulatory domain selected from: a CD28 costimulatory domain or a variant thereof having 1-5 amino acid modifications, a 4-1BB costimulatory domain or a variant thereof having 1-5 amino acid modifications and an OX40 costimulatory domain or a variant thereof having 1-5 amino acid modifications; and CD3 ζ signaling domain or a variant thereof having 1-5 amino acid modifications, wherein the chlorotoxin or variant thereof enables the chimeric antigen receptor, when expressed on the surface of a T cell, to direct T cell activity to glioblastoma cells.
A compound of formula wherein A is CH or N R 1 is C 1 -C 4 alkyl R 2 is hydrogen, cyano, -C R7, -C OR8, C 1 -C 6 alkyl or -CONR 9 R 10, SO 2 R 11 wherein R 7 is hydrogen, C 1 -C 6 alkyl or C 1 -C 6 haloalkyl and R 8 is C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 9, R 10 independently of one another are hydrogen or C 1 -C 6 alkyl; R 11 is C 1 -C 6 alkyl; R 3 is hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, cyano, -CO 2 H, -CO 2 NH 2, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylaminocarbonyl, C 1 -C 4 dialkylaminocarbonyl n is 0 or 1; Q is a radical selected from the group consisting of formulae Q 2, Q 3, Q 4 and Q 5 wherein the arrow denotes the point of attachment to the ring incorporating the radical A; and wherein R 4 is trifluoromethyl, trifluoromethylsulfanyl or trifluoromethylsulfonyl; R 5 is C 1 -C 4 alkyl; R 6 is OCH 3, CH 2 CH 3 or cyclopropyl; G 1 and G 2 are, independently from each other, N or CH; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer or N-oxide of a compound of formula I. A is CH or N R 1 is C 1 -C 4 alkyl R 2 is hydrogen, cyano, -C R7, -C OR8, C 1 -C 6 alkyl or -CONR 9 R 10, SO 2 R 11 wherein R 7 is hydrogen, C 1 -C 6 alkyl or C 1 -C 6 haloalkyl and R 8 is C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; R 9, R 10 independently of one another are hydrogen or C 1 -C 6 alkyl; R 11 is C 1 -C 6 alkyl; R 3 is hydrogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, cyano, -CO 2 H, -CO 2 NH 2, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylaminocarbonyl, C 1 -C 4 dialkylaminocarbonyl n is 0 or 1; Q is a radical selected from the group consisting of formulae Q 2, Q 3, Q 4 and Q 5 wherein the arrow denotes the point of attachment to the ring incorporating the radical A; and wherein R 4 is trifluoromethyl, trifluoromethylsulfanyl or trifluoromethylsulfonyl; R 5 is C 1 -C 4 alkyl; R 6 is OCH 3, CH 2 CH 3 or cyclopropyl; G 1 and G 2 are, independently from each other, N or CH; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer or N-oxide of a compound of formula I.