A packing apparatus in a sterile environment with a loading and supply system of articles, the apparatus comprising a series of walls (P1, P2, P3, P4) assembled to one another and predisposed in such a way as to identify and circumscribe an isolated environment from a surrounding environment, in which isolated environment measures are predisposed to maintain the isolated environment in sterile and aseptic conditions, at least a line and a series of operating stations associated to the line for the packing operations, and a loading and supply system which comprises: a hatch, realised and predisposed on a first wall of the walls (P1, P2, P3, P4) such as to be facing and in proximity of an operating station of the operating stations of the apparatus, and in a position such as to be at a height from a ground level corresponding to a normal, ergonomic and unified working height for an operative; and a container element for containing articles having a shape that is such as to exhibit an internal volume for containing articles, a first load opening communicating with the internal volume, for loading the articles into the internal volume, and a second unloading opening, communicating with the internal volume, for unloading the articles from the internal volume to externally of the container element, with the container element which is predisposed such as to be positioned internally of the isolated environment in a zone in proximity of the operating station which is to be supplied with the articles and further predisposed such as to be movable both with respect to the operative station and the hatch in such a way that: it is movable in order to be positioned in a lowered position at the hatch so that the first load opening is positioned at the hatch, such as to enable loading of the articles into the internal volume via the hatch and the first load opening and thereafter it is movable to be positioned in a raised position in such a way that the second unloading opening is positioned above the supply zone of the operating station to be supplied with the articles and with an orientation and configuration such that the articles contained in the internal volume remain within the volume and, when it is positioned in the raised position, the container element is further movable in such a way that the articles contained in the internal volume are directed towards the second unloading opening to be unloaded to outside the container element at the supply zone of the operating station, said loading and supply system further comprising a support frame of the container element, predisposed in such a way as to be positioned internally of the isolated environment, in a zone in proximity of the operating station which is to be supplied with the articles, and mounted with respect to a second wall of the walls (P1, P2, P3, P4) which circumscribe the isolated environment, opposite the first wall, in such a way as to be movable in rotation about a first rotation axis parallel to the second wall, in such a way that the container element can be movable in order to be positionable in the lowered position and in the raised position, and further movable in rotation about a second rotation axis, perpendicular to the first rotation axis and perpendicular to the second wall, such that the container element, when positioned in the raised position, can be moved in rotation about the second rotation axis, in such a way that the articles contained in the internal volume are directed towards the second unloading opening for unloading the container element to the outside at the supply zone of the operating station.