mhurhangee/ep-ind-claims huggingface dataset:
A lyophilized therapeutic peptibody composition comprising a buffer, a bulking agent, a stabilizing agent, and a surfactant, wherein said buffer is comprised of a pH buffering agent, wherein said buffering agent is 10 mM glutamate, pH 4.5; said bulking agent is 4% w/v mannitol; said stabilizing agent is 2% w/v sucrose; and said surfactant is 0.004% w/v polysorbate-20; and wherein said therapeutic peptibody comprises a structure set out in Formula I, Formula I: [(X 1) a -F 1 -(X 2) b]-(L 1) c -WSP d wherein: F 1 is an Fc domain; X 1 is selected from: P 1 -(L 2) e - P 2 -(L 3) f -P 1 (L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e; X 2 is selected from: -(L 2) e -P 1, -(L 2) e -P 1 -(L 3) f -P 2, -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3 -(L 5) h -P 4; wherein P 1, P 2, P 3, and P 4 are each independently sequences of pharmacologically active peptides; L 1, L 2, L 3, L 4, and L 5 are each independently linkers; a, b, c, e, f, g, and h are each independently 0 or 1, provided that at least one of a and b is 1; d is 0, 1, or greater than 1; and WSP is a water soluble polymer, the attachment of which is effected at any reactive moiety in F 1. F 1 is an Fc domain; X 1 is selected from: P 1 -(L 2) e - P 2 -(L 3) f -P 1 (L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e; P 1 -(L 2) e - P 2 -(L 3) f -P 1 (L 2) e - P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e - and P 4 -(L 5) h -P 3 -(L 4) g -P 2 -(L 3) f -P 1 -(L 2) e; X 2 is selected from: -(L 2) e -P 1, -(L 2) e -P 1 -(L 3) f -P 2, -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3 -(L 5) h -P 4; wherein P 1, P 2, P 3, and P 4 are each independently sequences of pharmacologically active peptides; -(L 2) e -P 1, -(L 2) e -P 1 -(L 3) f -P 2, -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3, and -(L 2) e -P 1 -(L 3) f -P 2 -(L 4) g -P 3 -(L 5) h -P 4; wherein P 1, P 2, P 3, and P 4 are each independently sequences of pharmacologically active peptides; L 1, L 2, L 3, L 4, and L 5 are each independently linkers; a, b, c, e, f, g, and h are each independently 0 or 1, provided that at least one of a and b is 1; d is 0, 1, or greater than 1; and WSP is a water soluble polymer, the attachment of which is effected at any reactive moiety in F 1.
A method for use in encoding video data within a sequence of video frames, the method comprising; encoding at least a portion of a reference frame using motion vector information associated with said portion of said reference frame, wherein said portion of said reference frame is a macroblock; defining at least a direct mode macroblock of a B frame that is collocated with said portion of said reference frame; and encoding at least said direct mode macroblock of said B frame without including corresponding motion vector information for said direct mode macroblock in a bit stream but including mode identifying data in the bit stream, wherein said encoding of said direct mode macroblock of said B frame can make use of spatial motion vector prediction with motion vector information of surrounding macroblocks in the B frame, and wherein the mode identifying data identifies how said direct mode macroblock of said B frame can be directly derived using said motion vector information associated with said portion of said reference frame or spatial motion vector prediction with said motion vector information of surrounding macroblocks in the B frame.
A method for conducting maintenance on a chromatography column, said column comprising a column tube, a top end cell and a bottom end cell, where during chromatography said column tube is secured between said top end cell and said bottom end cell, said top end cell being secured to rotatable upper fastening means on a stand by diametrically opposed engaging means of the top end cell, the corresponding diameter representing an horizontal axis, wherein said method comprises, in that order, the steps of: a) releasing the column tube from the top end cell; b) lowering the bottom end cell together with the column tube; c) rotating, in situ, the top end cell 180 degrees around said horizontal axis; and d) conducting maintenance to the top end cell. a) releasing the column tube from the top end cell; b) lowering the bottom end cell together with the column tube; c) rotating, in situ, the top end cell 180 degrees around said horizontal axis; and d) conducting maintenance to the top end cell.
A method of repairing a piston seal assembly for a gas turbine engine, comprising: removing worn material from a piston seal groove to generate a worked seal groove; applying a groove buildup member to the worked seal groove; and disposing a seal member proximate the groove buildup member, wherein the groove buildup member is a guard type member, characterised in that the guard type member is configured to interface with a reduced wall of the piston seal assembly and comprises an inner guard and an outer guard each joined at a distal end by an orthogonal web, wherein the inner guard is relatively longer than the outer guard, wherein the inner guard is disposed within the worked seal groove. removing worn material from a piston seal groove to generate a worked seal groove; applying a groove buildup member to the worked seal groove; and disposing a seal member proximate the groove buildup member, wherein the groove buildup member is a guard type member, characterised in that the guard type member is configured to interface with a reduced wall of the piston seal assembly and comprises an inner guard and an outer guard each joined at a distal end by an orthogonal web, wherein the inner guard is relatively longer than the outer guard, wherein the inner guard is disposed within the worked seal groove.
A method of continuously casting metal strip with reduced ridges comprising: assembling a pair of counter-rotatable casting rolls to form a gap at a nip between the casting rolls through which thin cast strip can be cast, each casting roll having casting surfaces with at least a center portion and edge portion, the center portion having a surface roughness varied across said center portion to correspond to a desired variation in metal shell thickness across the cast strip, assembling a metal delivery system adapted to deliver molten metal above the nip to form a casting pool supported on the casting surfaces of the casting rolls and confined at the edges of the casting rolls, and counter-rotating the casting rolls to form metal shells on the casting surfaces of the casting rolls that are brought together at the nip to deliver cast strip downwardly with varied thicknesses of the metal shells across the strip width, wherein the surface roughness of the center portion is tapered across the width in stepped zones, with: (i) the average surface roughness (Ra) of the stepped zones being in a range between 5 and 12 microns, and (ii) the middle part of the center portion having an average surface roughness at least 2 microns below the average surface roughness at the outermost parts of the center portion. assembling a pair of counter-rotatable casting rolls to form a gap at a nip between the casting rolls through which thin cast strip can be cast, each casting roll having casting surfaces with at least a center portion and edge portion, the center portion having a surface roughness varied across said center portion to correspond to a desired variation in metal shell thickness across the cast strip, assembling a metal delivery system adapted to deliver molten metal above the nip to form a casting pool supported on the casting surfaces of the casting rolls and confined at the edges of the casting rolls, and counter-rotating the casting rolls to form metal shells on the casting surfaces of the casting rolls that are brought together at the nip to deliver cast strip downwardly with varied thicknesses of the metal shells across the strip width, wherein the surface roughness of the center portion is tapered across the width in stepped zones, with: (i) the average surface roughness (Ra) of the stepped zones being in a range between 5 and 12 microns, and (ii) the middle part of the center portion having an average surface roughness at least 2 microns below the average surface roughness at the outermost parts of the center portion. (i) the average surface roughness (Ra) of the stepped zones being in a range between 5 and 12 microns, and (ii) the middle part of the center portion having an average surface roughness at least 2 microns below the average surface roughness at the outermost parts of the center portion.
Nebulizer, in particular an inhaler, for a fluid, comprising: a replaceable container containing the fluid, and a counting device for counting the number of operations with the current container, wherein the container is moveable within the nebulizer and relative to a housing part of the nebulizer during conveying of the fluid, pressure generation and/or nebulization, wherein the container is provided with an electronic storage, and wherein the container comprises connecting means for electrically connecting the electronic storage, wherein the connecting means is located at a base of the container, wherein the connecting means is adapted to allow a respective movement of the electronic storage associated to the container relative to the counting device or its circuit board associated to the housing part and to provide the electrical connection to the electronic storage only in an end position of the container, wherein the connecting means comprises multiple conductors which are arranged ring-like, characterized in that the conductors are arranged coaxially on the lower end face of the container. a replaceable container containing the fluid, and a counting device for counting the number of operations with the current container, wherein the container is moveable within the nebulizer and relative to a housing part of the nebulizer during conveying of the fluid, pressure generation and/or nebulization, wherein the container is provided with an electronic storage, and wherein the container comprises connecting means for electrically connecting the electronic storage, wherein the connecting means is located at a base of the container, wherein the connecting means is adapted to allow a respective movement of the electronic storage associated to the container relative to the counting device or its circuit board associated to the housing part and to provide the electrical connection to the electronic storage only in an end position of the container, wherein the connecting means comprises multiple conductors which are arranged ring-like, characterized in that the conductors are arranged coaxially on the lower end face of the container.
A milking cluster for a milking parlor for milking milk-producing animals, said milking cluster having at least one teat cup unit (10, 10', 10") with a housing, a teat cup, a drive device and a pulling element arrangement which is connected to the teat cup, wherein the pulling element arrangement has a segment unit with at least two pulling elements (16, 16', 17), characterized in that the teat cup has a connection portion with a fixing device which cooperates with a corresponding tilt segment of the segment unit, and that the segment unit has several intermediate segments which are arranged between a fixing segment which is attached on the housing and the tilt segment 13, wherein the at least two pulling elements (16, 16') of the pulling element arrangement are arranged one above the other.
A method for producing salamis and sausages with low fat content, comprising the following steps: a. providing crumb obtained from a dough based on whey proteins or ground crumb of sandwich loaf; b. soaking said crumb with vegetable food oil; c. preparing a paste based on ground meat and/or animal fat comprising said crumb, wherein the percentage of crumb by weight of the paste weight is equal or higher than 50%, wherein the step of providing crumb obtained from a dough based on whey proteins comprises the following sub-steps: - mixing whey proteins, NaCl, Na 2 CO 3 and water; - baking the mixture obtained in an oven; - grinding the baked mixture. a. providing crumb obtained from a dough based on whey proteins or ground crumb of sandwich loaf; b. soaking said crumb with vegetable food oil; c. preparing a paste based on ground meat and/or animal fat comprising said crumb, wherein the percentage of crumb by weight of the paste weight is equal or higher than 50%, wherein the step of providing crumb obtained from a dough based on whey proteins comprises the following sub-steps: - mixing whey proteins, NaCl, Na 2 CO 3 and water; - baking the mixture obtained in an oven; - grinding the baked mixture.
An inkjet cartridge, comprising: a) an ink cartridge body; b) an ink reservoir disposed within the ink cartridge body and adapted to receive and contain ink; c) the ink cartridge body including a tower; d1) a chamber inside the tower that holds ink; d2) a plurality of extending elements formed by pillars (81, 82, 83) attached at the bottom of the chamber disposed within the chamber, the ink passing through the chamber and around the plurality of extending elements, wherein the extending elements are spaced apart from, and are substantially parallel to, one another; d3) a plurality of trenches (89, 90) disposed within the chamber, wherein the plurality of trenches are defined by the spaces between the extending elements; and d4) a free-floating member formed as a slider free floating in the sense that it is not physically connected to other elements in the tower and positioned within the tower that agitates the ink within the tower, the free-floating member comprising a bridging member and a plurality of shafts (84, 85, 86) protruding from the bridging member substantially parallel to one another, the shafts (84, 85) situated within the trenches (89, 90) between the extending elements (81, 82, 83) with one shaft arranged in the chamber outside the trenches adjacent to one extending element. a) an ink cartridge body; b) an ink reservoir disposed within the ink cartridge body and adapted to receive and contain ink; c) the ink cartridge body including a tower; d1) a chamber inside the tower that holds ink; d2) a plurality of extending elements formed by pillars (81, 82, 83) attached at the bottom of the chamber disposed within the chamber, the ink passing through the chamber and around the plurality of extending elements, wherein the extending elements are spaced apart from, and are substantially parallel to, one another; d3) a plurality of trenches (89, 90) disposed within the chamber, wherein the plurality of trenches are defined by the spaces between the extending elements; and d4) a free-floating member formed as a slider free floating in the sense that it is not physically connected to other elements in the tower and positioned within the tower that agitates the ink within the tower, the free-floating member comprising a bridging member and a plurality of shafts (84, 85, 86) protruding from the bridging member substantially parallel to one another, the shafts (84, 85) situated within the trenches (89, 90) between the extending elements (81, 82, 83) with one shaft arranged in the chamber outside the trenches adjacent to one extending element.
Protective device (10; 110; 210) comprising a protective cover and further comprising a needle-protecting cap inside the protective cover, wherein the protective cover is made of a rigid material, intended to be gripped on the needle-protecting cap, made of a flexible material, of a syringe to take the needle-protecting cap away from the needle upon the removal of the said protective cover, said protective cover having an internal surface (13; 113; 213) and comprising claws (20; 120; 220) protruding from this internal surface, said claws (20; 120; 220) configured to grip the needle-protecting cap and the claws (20; 120; 220) having a free end in the form of a point arranged so as to stick into the needle-protecting cap, wherein the claws (20; 120; 220): - are downstream oriented, - are integral with the protective cover, - and characterised in that the claws (20; 120; 220) are fixed in respect of said internal surface (13; 113; 213) without any articulation. - are downstream oriented, - are integral with the protective cover, - and characterised in that the claws (20; 120; 220) are fixed in respect of said internal surface (13; 113; 213) without any articulation.
A work vehicle comprising an engine configured to output power that has a rotational speed corresponding to an operation on an engine rotational speed changing operation member, a traveling-system transmission disposed in a traveling-system power transmission path from the engine to travel members (20F, 20R) and configured to perform a speed change action corresponding to an operation on a traveling-system speed changing operation member, a multi-stage PTO transmission disposed in an working-system power transmission path from the engine to a PTO shaft and configured to perform a speed change action corresponding to an operation on a PTO speed changing operation member, a display device (400, 450) having a liquid crystal display part, and a control device, characterized in that the control device calculates, for each of a plurality of speed-changing stages in the PTO transmission, an expected maximum rotational speed of PTO rotary power that is output from the PTO shaft when the engine rotational speed changing operation member is operated to a maximum extent, and shows the calculated results in the liquid crystal display part in a listed manner.
A flexible printed board comprising: a base film with an optical transmissivity; a recognition mark formed in the form of copper foil pattern on a first face of the base film, wherein the copper foil pattern has a hollow shape with an outer circumferential section and an inner circumferential section; a first face coverlay having an opening formed therein, wherein the first face coverlay is bonded to the first face of the base film and covers the outer circumferential section of the copper foil pattern such that an edge of the opening is positioned between the outer circumferential section and the inner circumferential section of the copper foil pattern; an adhesive between the first face coverlay and the base film; and a second face coverlay having a larger opening formed therein than the copper foil pattern, wherein the second face coverlay is bonded to a second face of the base film such that the copper foil pattern is contained within the opening when viewed through the base film. a base film with an optical transmissivity; a recognition mark formed in the form of copper foil pattern on a first face of the base film, wherein the copper foil pattern has a hollow shape with an outer circumferential section and an inner circumferential section; a first face coverlay having an opening formed therein, wherein the first face coverlay is bonded to the first face of the base film and covers the outer circumferential section of the copper foil pattern such that an edge of the opening is positioned between the outer circumferential section and the inner circumferential section of the copper foil pattern; an adhesive between the first face coverlay and the base film; and a second face coverlay having a larger opening formed therein than the copper foil pattern, wherein the second face coverlay is bonded to a second face of the base film such that the copper foil pattern is contained within the opening when viewed through the base film. an adhesive between the first face coverlay and the base film; and a second face coverlay having a larger opening formed therein than the copper foil pattern, wherein the second face coverlay is bonded to a second face of the base film such that the copper foil pattern is contained within the opening when viewed through the base film.
A caster wheel assembly of a pickup for an agricultural machine, comprising a wheel (11, 41) on a carrier shaft (14, 24, 34, 44) mounted rotatably within a bushing (13, 23, 33, 43) of a pickup arm (10, 20, 40), the wheel (11, 41) being biased by a spring (16, 26, 36, 46) to be oriented in a predetermined direction relative to the pickup arm, characterized in that the spring (16, 26, 36, 46) is a helical spring mounted coaxially with the carrier shaft between the wheel and the pickup arm, and the helical spring (16, 26, 36, 46) is attached at its one end to the carrier shaft (14, 24, 34, 44) and at its second end to the bushing (13, 23, 33, 43).
An isolated double stranded nucleic acid molecule directed against superoxide dismutase 1 comprising a guide strand and a passenger strand, wherein the isolated double stranded nucleic acid molecule includes a double stranded region and a single stranded region, wherein the region of the molecule that is double stranded is from 8-15 nucleotides long, wherein the guide strand contains a single stranded region that is 2-14 nucleotides long, wherein the guide strand contains 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 or 22 phosphorothioate modifications, wherein the passenger strand is 8 to 15 nucleotides long, wherein the passenger strand contains 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 phosphorothioate modifications, wherein at least 40% of the nucleotides of the isolated double stranded nucleic acid molecule are modified, and wherein: (i) the passenger strand comprises SEQ ID NO: 2, SEQ ID NO: 32, or SEQ ID NO: 122, and the guide strand comprises SEQ ID NO: 61, SEQ ID NO: 91, or SEQ ID NO: 123: (ii) the passenger strand comprises SEQ ID NO: 4, SEQ ID NO: 34, or SEQ ID NO: 126, and the guide strand comprises SEQ ID NO: 63 or SEQ ID NO: 93; (iii) the passenger strand comprises SEQ ID NO: 9, SEQ ID NO: 38, or SEQ ID NO:135, and the guide strand comprises SEQ ID NO: 68, SEQ ID NO: 97, or SEQ ID NO: 136; (iv) the passenger strand comprises SEQ ID NO: 10 or SEQ ID NO: 39, and the guide strand comprises SEQ ID NO: 69 or SEQ ID NO: 98; or (v) the passenger strand comprises SEQ ID NO: 5, SEQ ID NO: 127 or SEQ ID NO: 137, and the guide strand comprises SEQ ID NO: 64, SEQ ID NO: 128 or SEQ ID NO: 138. (i) the passenger strand comprises SEQ ID NO: 2, SEQ ID NO: 32, or SEQ ID NO: 122, and the guide strand comprises SEQ ID NO: 61, SEQ ID NO: 91, or SEQ ID NO: 123: (ii) the passenger strand comprises SEQ ID NO: 4, SEQ ID NO: 34, or SEQ ID NO: 126, and the guide strand comprises SEQ ID NO: 63 or SEQ ID NO: 93; (iii) the passenger strand comprises SEQ ID NO: 9, SEQ ID NO: 38, or SEQ ID NO:135, and the guide strand comprises SEQ ID NO: 68, SEQ ID NO: 97, or SEQ ID NO: 136; (iv) the passenger strand comprises SEQ ID NO: 10 or SEQ ID NO: 39, and the guide strand comprises SEQ ID NO: 69 or SEQ ID NO: 98; or (v) the passenger strand comprises SEQ ID NO: 5, SEQ ID NO: 127 or SEQ ID NO: 137, and the guide strand comprises SEQ ID NO: 64, SEQ ID NO: 128 or SEQ ID NO: 138.