mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for determining if an allergic patient, who is undergoing an allergen immunotherapy which is a desensitization therapy, is developing an immune response oriented either towards a regulatory T cell response or towards an effector T cell response, which method comprises: a) determining the level of expression of at least STAB1 protein, or an mRNA thereof, in PBMCs from the patient; b) comparing said level of expression with that of a control which consists of (i) immature dendritic cells which have not been polarized towards tolerogenic or effector subsets, or (ii) PBMCs from the patient obtained before said patient undergoes allergen immunotherapy; c) based on the comparison with the control, identifying that the immune response developed by the patient is oriented - either towards a regulatory T cell response if the level of expression of at least STAB1 protein, or an mRNA thereof, is higher than that of the control, or - towards an effector T cell if the level of expression of at least STAB1 protein, or an mRNA thereof, is lower than that of the control. a) determining the level of expression of at least STAB1 protein, or an mRNA thereof, in PBMCs from the patient; b) comparing said level of expression with that of a control which consists of (i) immature dendritic cells which have not been polarized towards tolerogenic or effector subsets, or (ii) PBMCs from the patient obtained before said patient undergoes allergen immunotherapy; c) based on the comparison with the control, identifying that the immune response developed by the patient is oriented - either towards a regulatory T cell response if the level of expression of at least STAB1 protein, or an mRNA thereof, is higher than that of the control, or - towards an effector T cell if the level of expression of at least STAB1 protein, or an mRNA thereof, is lower than that of the control. - either towards a regulatory T cell response if the level of expression of at least STAB1 protein, or an mRNA thereof, is higher than that of the control, or - towards an effector T cell if the level of expression of at least STAB1 protein, or an mRNA thereof, is lower than that of the control.
Monitoring system for a multiple-walled fluid system with a first walled region comprising a flowing or stagnant fluid and at least one second walled region (2, 2') at least partially surrounding the first walled region, the first walled region and the at least one second walled region (2, 2') forming the multiple-walled fluid system, characterized in that the first walled region being in fluid communication (A 12) with the at least one second walled region, the at least one second walled region also being in fluid communication (A 2E) with the ambient environment, in particular via a fluid connection (A 22') with a further second walled region, a first control volume in fluid connection (A 1C, A CE) with the first walled region and the ambient environment, in particular via fluid connections (A CC', A C'E) through a further control volume (C'), with a data processing device for monitoring at least one pressure difference between a pressure (p C, p C') in at least one of the control volume (C, C') and at least one second pressure (p 2, p 2') in the at least one second walled region (2, 2'), the at least one pressure difference (p C - p 2, p C' - p 2') indicating the status of the multiple-walled fluid system, in particular the mechanical integrity of at least one of the walled regions (1, 2, 2').
Method for increasing the toughness of a material obtained by curing a composition comprising at least one vinylester monomer comprising at least two reactive sites of formula -O-CO-CR=CH 2, wherein R represents a hydrogen atom or a methyl group, and a bisphenol A unit and/or a novolac unit, which method comprises the incorporation into this composition of a sulfonated polyaromatic thermoplastic polymer, this incorporation being achieved by dissolving the vinylester monomer and the thermoplastic polymer in a reactive diluent in which they are both soluble, the reactive diluent being a N -vinyl lactam.
A multi-link piston-crank mechanism for an internal combustion engine, comprising: an upper link connected through a piston pin with a piston; a lower link swingably connected through a first connecting pin with the upper link; a control link including one end swingably connected through a second connecting pin with the lower link; and a control shaft rotatably attached to a cylinder block, the control shaft including an eccentric shaft that swingably supports another end of the control link, wherein the lower link is formed with a crankpin through-hole through which a crankpin is passing, the lower link is rotatably attached to the crankpin through a cylindrical bearing metal held in the crankpin through-hole, the lower link is formed such that rigidity of outer circumferential portions of both end portions of the crankpin through-hole is higher than rigidity of an outer circumferential portion of a center portion of the crankpin through-hole, and inner diameters of the both end portions of the crankpin through-hole are larger than an inner diameter of the center portion of the crankpin through-hole, characterized in that an inner circumferential surface of the crankpin through-hole is curved along the axial direction of the crankshaft at a curvature according to rigidity of an outer circumferential portion of the crankpin through-hole, and the curvature is set such that a part of the outer circumferential portion of the crankpin through-hole which has a high rigidity has a curvature level larger than that of a part of the outer circumferential portion of the crankpin through-hole which has a low rigidity. an upper link connected through a piston pin with a piston; a lower link swingably connected through a first connecting pin with the upper link; a control link including one end swingably connected through a second connecting pin with the lower link; and a control shaft rotatably attached to a cylinder block, the control shaft including an eccentric shaft that swingably supports another end of the control link, wherein the lower link is formed with a crankpin through-hole through which a crankpin is passing, the lower link is rotatably attached to the crankpin through a cylindrical bearing metal held in the crankpin through-hole, the lower link is formed such that rigidity of outer circumferential portions of both end portions of the crankpin through-hole is higher than rigidity of an outer circumferential portion of a center portion of the crankpin through-hole, and inner diameters of the both end portions of the crankpin through-hole are larger than an inner diameter of the center portion of the crankpin through-hole, characterized in that an inner circumferential surface of the crankpin through-hole is curved along the axial direction of the crankshaft at a curvature according to rigidity of an outer circumferential portion of the crankpin through-hole, and the curvature is set such that a part of the outer circumferential portion of the crankpin through-hole which has a high rigidity has a curvature level larger than that of a part of the outer circumferential portion of the crankpin through-hole which has a low rigidity.
A method for generating additive manufacturing instructions comprising: acquiring, at a processor, a first data model and a second data model, wherein: the first data model comprises a geometric model characterising the geometry of at least part of a first object, and the second data model comprises a geometric model characterising the geometry of at least part of a second object, and the first and second objects are to be generated in a common additive manufacturing operation; generating, using the processor, a first print layer model and a second, different, print layer model, wherein each of the print layer models comprises a data model of an intended print layer in object generation, wherein the layer is to comprise at least part of the first and second object and wherein: generating the first print layer model comprises combining the geometrical models of the first and second data models to determine the locations of object portions within the layer, and generating the second print layer model comprises generating a model characterising a separation between the objects to expose a way in which the objects could interact or influence one another during object generation; the method further comprising generating additive manufacturing instructions based on the first print layer model and the second print layer model. the first data model comprises a geometric model characterising the geometry of at least part of a first object, and the second data model comprises a geometric model characterising the geometry of at least part of a second object, and the first and second objects are to be generated in a common additive manufacturing operation; generating, using the processor, a first print layer model and a second, different, print layer model, wherein each of the print layer models comprises a data model of an intended print layer in object generation, wherein the layer is to comprise at least part of the first and second object and wherein: generating the first print layer model comprises combining the geometrical models of the first and second data models to determine the locations of object portions within the layer, and generating the second print layer model comprises generating a model characterising a separation between the objects to expose a way in which the objects could interact or influence one another during object generation; the method further comprising generating additive manufacturing instructions based on the first print layer model and the second print layer model. generating the first print layer model comprises combining the geometrical models of the first and second data models to determine the locations of object portions within the layer, and generating the second print layer model comprises generating a model characterising a separation between the objects to expose a way in which the objects could interact or influence one another during object generation; the method further comprising generating additive manufacturing instructions based on the first print layer model and the second print layer model.
Apparatus for data transmission between a position measuring device and downstream electronics via a data transmission channel, wherein the position measuring device comprises an interface unit and a processing unit, the interface unit is connected firstly to the data transmission channel and secondly, for the purpose of internal data interchange, by means of a request channel and a response channel to the processing unit, wherein the interface unit comprises a command interpreter that can be used, using conversion rules (R0.. Rn; Rn+1), to convert commands that arrive via the data transmission channel into internal requests and to supply said requests to the processing unit via the request channel, and to convert response data that arrive from the processing unit via the response channel into output data, and the interface unit additionally comprises a rule memory for storing the conversion rules (R0.. Rn; Rn+1), and the rule memory is modifiable at least to some extent.
A compound of Formula I wherein: R 1 is selected from hydrogen, alkyl, or cycloalkyl; R 2 is tetrahydroisoquinolinyl and is substituted with 1 R 6 substituent and also with 0-3 halo or alkyl substituents; R 3 is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; R 4 is selected from alkyl or haloalkyl; R 5 is alkyl; and R 6 is selected from benzothiazolyl, pyrazolopyrimidinyl, thiazolopyridinyl, triazolopymidinyl, benzooxazolyl, pyrrolopyrimidinyl, purinyl, imidazopyridinyl, benzoisoxazolyl, benzoimidazolyl or thienopyrimidinyl, and is substituted with 0-3 substituents selected from amino, cyano, halo, hydroxyl, alkyl, haloalkyl, alkoxy, and haloalkoxy; or a pharmaceutically acceptable salt thereof. R 1 is selected from hydrogen, alkyl, or cycloalkyl; R 2 is tetrahydroisoquinolinyl and is substituted with 1 R 6 substituent and also with 0-3 halo or alkyl substituents; R 3 is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; R 4 is selected from alkyl or haloalkyl; R 5 is alkyl; and R 6 is selected from benzothiazolyl, pyrazolopyrimidinyl, thiazolopyridinyl, triazolopymidinyl, benzooxazolyl, pyrrolopyrimidinyl, purinyl, imidazopyridinyl, benzoisoxazolyl, benzoimidazolyl or thienopyrimidinyl, and is substituted with 0-3 substituents selected from amino, cyano, halo, hydroxyl, alkyl, haloalkyl, alkoxy, and haloalkoxy; or a pharmaceutically acceptable salt thereof.
Composition obtained by centrifuging blood, separating platelet-rich plasma and adding calcium chloride to the platelet-rich plasma thereby causing a release of growth factors by platelets contained in the plasma and the plasma to coagulate until it acquires a consistency similar to a gel, for its use as a therapeutic substance to be administered intranasally in the treatment of a neurodegenerative disease.
A method for communicating data underwater between at least one master node and a plurality of slave nodes, the master and slave nodes having synchronized clocks, comprising: defining time slots during which the master node will receive data from at least one slave node; a slave node calculating, using a processor having access to information regarding a distance between the slave node and the master node, a time to acoustically transmit data so that the acoustically transmitted data is received by the master node during a defined time slot; the slave node, at the calculated time, acoustically transmitting the data; and receiving the data transmitted by the slave node at the master node during the defined time slot, wherein the master node receives acoustic transmissions having at least first and second frequencies, the second frequency being higher than the first frequency, wherein the slave nodes communicate with the master node at the first frequency when a distance between the slave node and the master node is greater than a first threshold distance, and wherein the slave nodes communicate with the master node at the second frequency when the distance between the slave node and the master node is less than a second threshold distance, smaller than the first threshold distance. defining time slots during which the master node will receive data from at least one slave node; a slave node calculating, using a processor having access to information regarding a distance between the slave node and the master node, a time to acoustically transmit data so that the acoustically transmitted data is received by the master node during a defined time slot; the slave node, at the calculated time, acoustically transmitting the data; and receiving the data transmitted by the slave node at the master node during the defined time slot, wherein the master node receives acoustic transmissions having at least first and second frequencies, the second frequency being higher than the first frequency, wherein the slave nodes communicate with the master node at the first frequency when a distance between the slave node and the master node is greater than a first threshold distance, and wherein the slave nodes communicate with the master node at the second frequency when the distance between the slave node and the master node is less than a second threshold distance, smaller than the first threshold distance.
A method for manufacturing an optical duplexer intended to receive light at a first optical wavelength (λ1) and to transmit back light at a second optical wavelength (λ2), comprising the steps of: forming, on a first silicon wafer, a photoreceptor of the first optical wavelength (λ1), comprising semiconductor regions, successively heavily doped of a first conductivity type intrinsic, and heavily doped of a second conductivity type, and coating the assembly with a planar bonding layer, forming on a second SOI-type wafer, in the upper silicon layer of the SOI structure, a waveguide adapted to receive light from a source at the second optical wave length, having a surface comprising a grating which is transparent for the first optical wavelength (λ1) and diffracting for the second optical wavelength (λ2), and depositing successive layers forming a selective filter letting through the first optical wavelength and not the second optical wavelength and coating the assembly with a planar bonding layer, and bonding the surface opposite to the substrate of the first wafer to the surface opposite to the substrate of the second wafer and removing the silicon substrate of the second wafer. forming, on a first silicon wafer, a photoreceptor of the first optical wavelength (λ1), comprising semiconductor regions, successively heavily doped of a first conductivity type intrinsic, and heavily doped of a second conductivity type, and coating the assembly with a planar bonding layer, forming on a second SOI-type wafer, in the upper silicon layer of the SOI structure, a waveguide adapted to receive light from a source at the second optical wave length, having a surface comprising a grating which is transparent for the first optical wavelength (λ1) and diffracting for the second optical wavelength (λ2), and depositing successive layers forming a selective filter letting through the first optical wavelength and not the second optical wavelength and coating the assembly with a planar bonding layer, and bonding the surface opposite to the substrate of the first wafer to the surface opposite to the substrate of the second wafer and removing the silicon substrate of the second wafer.
Device for folding in a camera on a motor vehicle in order to protect the device in the event of a collision with an obstacle, in particular folding-in device for a mirror replacement system of a motor vehicle, having: a first housing element, in which the camera is received; a second housing element which is constructed to be connected to the motor vehicle in a positionally fixed manner; and an intermediate member, wherein the first housing element and the intermediate member are pivotably connected to each other by means of a first pivot connection and/or the second housing element and the intermediate member are pivotably connected to each other by means of a second pivot connection; wherein the first housing element and the second housing element are pivotably connected to each other by means of the first pivot connection, which defines a first rotation axis, and the second pivot connection, which defines a second rotation axis which is spaced apart from the first rotation axis, characterized in that the first housing element has a first connection region which is connected via the first pivot connection to the intermediate member and the intermediate member has a first guiding element, in particular a first guiding sleeve, which is supported on a first guiding contour of the first connection region; and/or the second housing element has a second connection region which is connected via the second pivot connection to the intermediate member and the intermediate member has a second guiding element, in particular a second guiding sleeve, which is supported on a second guiding contour of the second connection region. a first housing element, in which the camera is received; a second housing element which is constructed to be connected to the motor vehicle in a positionally fixed manner; and an intermediate member, wherein the first housing element and the intermediate member are pivotably connected to each other by means of a first pivot connection and/or the second housing element and the intermediate member are pivotably connected to each other by means of a second pivot connection; wherein the first housing element and the second housing element are pivotably connected to each other by means of the first pivot connection, which defines a first rotation axis, and the second pivot connection, which defines a second rotation axis which is spaced apart from the first rotation axis, characterized in that the first housing element has a first connection region which is connected via the first pivot connection to the intermediate member and the intermediate member has a first guiding element, in particular a first guiding sleeve, which is supported on a first guiding contour of the first connection region; and/or the second housing element has a second connection region which is connected via the second pivot connection to the intermediate member and the intermediate member has a second guiding element, in particular a second guiding sleeve, which is supported on a second guiding contour of the second connection region.
Method of producing a patient-specific eye cavity cover grid, wherein a 3D primary model is formed of the bone structure to be covered or replaced in the region of an eye cavity of a patient to be treated, then a border region representative of the maximum spatial extension of the planned eye cavity cover grid is established, then a 2D secondary model is positioned within the border region over the 3D primary model so that the geometric dimensions of the 3D primary model transferred to the starting form of the original 2D secondary model lead to a 3D tertiary model which is used as the basis for the production of the eye cavity cover grid.
A method for programming the progress of an injection moulding cycle, comprising several sequences, of an injection moulding machine, wherein the sequences of the injection moulding cycle are taught individually, wherein the sequences of the injection moulding cycle are respectively manually started firstly as a whole or in part in a setup mode and subsequently as a whole or in part in a teaching mode, wherein in the setup mode parts of the injection moulding machine are first actuated and are tested as to the functionality thereof, and wherein the tested parts are then actuated once again in the teaching mode according to the desired sequence of movements, wherein this sequence of movements is stored in a controller of the injection moulding machine.
A robotic arm arrangement comprises an elongate robotic arm having a plurality of control cables (205, 414) extending along the arm for controlling the position of the arm, a corresponding plurality of actuators (206, 400) for actuating the control cables, and a coupling arrangement between each cable and the associated actuator, the coupling arrangement comprising a coupling member, in which each coupling member extends radially outwardly with respect to the arm, and is arranged such that the actuators produce axial movement of the cables, characterised in that the coupling arrangement is releasable, and wherein the cables extend axially out of an end of arm plate, provided at the proximal end of the arm, and terminate at an arm base plate, with ferrules (302, 413) being provided between the end of arm plate and the arm base plate.