mhurhangee/ep-ind-claims huggingface dataset:
A compound having a formula, (IIa) or: or wherein R 1 is selected from the group consisting of -O(CH 2) m NEt 2; -O(CH 2) m NMe 2; -O(CH 2) m NHEt; -O(CH 2) m NHMe 2; -O(CH 2) m morpholinyl; -O(CH 2) m substituted morpholinyl; -O(CH 2) m Sulfoxymorpholinyl; -O(CH 2) m substituted sulfoxymorpholinyl; -O(CH 2) m pyrrolidinyl; -O(CH 2) m substituted pyrrolidinyl; -O(CH 2) m piperazinyl; -O(CH 2) m substituted piperazinyl; -O(CH 2) m piperidinyl; -O(CH 2) m substituted piperidinyl; -O(CH 2) m N(Me)(CH 2) 2 NMe 2; -O(CH 2) m N(Me)(CH 2) 2 NHMe; -O(CH 2) m N(Me)(CH 2) 2 NEt 2; -O(CH 2),N(Me)(CH 2) 2 NHEt; -O(CH 2) m O(CH 2) 2 NMe 2; -O(CH 2) m O(CH 2) 2 NHMe; -O(CH 2) m O(CH 2) 2 NEt 2; and O(CH 2) m O(CH 2) 2 NHEt; R 1A is selected from the group consisting of H, amido, substituted amido, halide, -(CH 2) m R 9, -NH(CH 2) m R 9, -NHC (CH 2) m R 9, -C NH(CH 2) m R 9 and -O(CH 2) m R 9; X is fluoro or chloro; R 2 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, Het is heteroaryl or substituted heteroaryl excluding 2-pyridyl; R 9 is amino, substituted amino, hydroxy, alkoxy, substituted alkoxy, cycloheteroalkyl, or substituted cycloheteroalkyl; and m is 2, 3, or 4, or salt thereof. wherein R 1 is selected from the group consisting of -O(CH 2) m NEt 2; -O(CH 2) m NMe 2; -O(CH 2) m NHEt; -O(CH 2) m NHMe 2; -O(CH 2) m morpholinyl; -O(CH 2) m substituted morpholinyl; -O(CH 2) m Sulfoxymorpholinyl; -O(CH 2) m substituted sulfoxymorpholinyl; -O(CH 2) m pyrrolidinyl; -O(CH 2) m substituted pyrrolidinyl; -O(CH 2) m piperazinyl; -O(CH 2) m substituted piperazinyl; -O(CH 2) m piperidinyl; -O(CH 2) m substituted piperidinyl; -O(CH 2) m N(Me)(CH 2) 2 NMe 2; -O(CH 2) m N(Me)(CH 2) 2 NHMe; -O(CH 2) m N(Me)(CH 2) 2 NEt 2; -O(CH 2),N(Me)(CH 2) 2 NHEt; -O(CH 2) m O(CH 2) 2 NMe 2; -O(CH 2) m O(CH 2) 2 NHMe; -O(CH 2) m O(CH 2) 2 NEt 2; and O(CH 2) m O(CH 2) 2 NHEt; R 1A is selected from the group consisting of H, amido, substituted amido, halide, -(CH 2) m R 9, -NH(CH 2) m R 9, -NHC (CH 2) m R 9, -C NH(CH 2) m R 9 and -O(CH 2) m R 9; X is fluoro or chloro; R 2 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, Het is heteroaryl or substituted heteroaryl excluding 2-pyridyl; R 9 is amino, substituted amino, hydroxy, alkoxy, substituted alkoxy, cycloheteroalkyl, or substituted cycloheteroalkyl; and m is 2, 3, or 4,
A device (10; 110) for aiding the memory of a user, said device comprising a series of actuators, which are independently actuatable by said user, and means for recording and storing a plurality of audible messages created by said user and assigning each of said audible messages to one of said actuators, wherein each of said audible messages is playable by actuation of the actuator to which it is assigned, and the series of said actuators is arranged in an ordered sequence, the order being identifiable to the user by the physical arrangement of said actuators and visual indications associated with said actuators, and characterised in that said device (10; 110) further comprises means for assigning scheduled playback times to said audible messages, and said device (10; 110) is adapted to assign each of said audible messages to its actuator based on one or more rules such that said audible messages are ordered with respect to said ordered sequence of the series of actuators in an order according to said scheduled playback times, said device (10; 110) being adapted to play back the audible messages at the corresponding scheduled playback times.
A base station in a system supporting WWAN-WLAN aggregation communication in which a radio terminal performs communication using WWAN communication and WLAN communication simultaneously, the base station comprising: a controller configured to acquire capability information from the radio terminal that indicates a protocol architecture of WWAN-WLAN aggregation supported by the radio terminal, characterized in that a first protocol architecture of WWAN-WLAN aggregation and a second protocol architecture of WWAN-WLAN aggregation are defined in the WWAN-WLAN aggregation communication, the first protocol architecture of WWAN-WLAN aggregation splits a bearer of the radio terminal in a PDCP layer of the WWAN communication, and uses the WWAN communication and the WLAN communication for radio communication of the bearer, the second protocol architecture of WWAN-WLAN aggregation uses only the WLAN communication for the radio communication of the bearer without splitting the bearer going through the PDCP layer, and the controller is further configured to acquire capability information of the second protocol architecture of WWAN-WLAN aggregation as information different from capability information of the first protocol architecture of WWAN-WLAN aggregation. a controller configured to acquire capability information from the radio terminal that indicates a protocol architecture of WWAN-WLAN aggregation supported by the radio terminal, characterized in that a first protocol architecture of WWAN-WLAN aggregation and a second protocol architecture of WWAN-WLAN aggregation are defined in the WWAN-WLAN aggregation communication, the first protocol architecture of WWAN-WLAN aggregation splits a bearer of the radio terminal in a PDCP layer of the WWAN communication, and uses the WWAN communication and the WLAN communication for radio communication of the bearer, the second protocol architecture of WWAN-WLAN aggregation uses only the WLAN communication for the radio communication of the bearer without splitting the bearer going through the PDCP layer, and the controller is further configured to acquire capability information of the second protocol architecture of WWAN-WLAN aggregation as information different from capability information of the first protocol architecture of WWAN-WLAN aggregation.
An apparatus for extracting analytes from a liquid medium, comprising: a sample container, and a sorptive stirrer comprising a sorptive material; wherein said liquid medium is placed in said sample container; and wherein said sorptive stirrer is placed in said sample container; characterized in that the apparatus further comprises a cooling source for freezing the liquid medium from the bottom of the sample container in an upward direction, wherein said sample container is placed in or on said cooling source, and wherein the apparatus is adapted to perform simultaneously freeze concentrating and extracting the analyte into or by the sorptive material. a sample container, and a sorptive stirrer comprising a sorptive material; wherein said liquid medium is placed in said sample container; and wherein said sorptive stirrer is placed in said sample container;
Capsule for preparing a predetermined quantity of beverage suitable for consumption using an extractable product, comprising a circumferential wall, a bottom closing the circumferential wall at a first end, and a lid closing the circumferential wall at a second end opposite the bottom, wherein the wall, bottom and lid enclose an inner space comprising the extractable product, wherein the bottom comprises an entrance area arranged for supplying there through a fluid under pressure to the extractable product for preparing the beverage, wherein the lid comprises an exit area for draining there through the prepared beverage from the capsule, and wherein the entrance area of the capsule comprises an entrance filter for supplying the fluid to the extractable product there through, wherein the entrance filter is formed by a plurality of entrance openings provided in the bottom of the capsule, wherein the capsule further comprises a bottom seal at least partially removable connected to the bottom, to an optional rim positioned near the first end and/or to the circumferential wall for sealing the entrance filter prior to use, said bottom seal closing off the entrance openings, wherein the exit area comprises an exit filter through which the beverage can drain from the capsule, wherein the capsule further comprises a lid seal at least partially removable connected to the lid, to an optional rim positioned near the second end of the capsule and/or to the circumferential wall for sealing the exit filter prior to use wherein if the optional rim is present the optional rim is an outwardly extending rim at the second end wherein the lid is attached to the outwardly extending rim, wherein the bottom seal comprises a lip to allow easy removal of the bottom seal by a user of the capsule, and the lid seal comprises a lip to allow easy removal of the lid seal by a user of the capsule, characterized in that the lip of the bottom seal is connected to the lip of the lid seal.
A card insertion detection unit for a card processing apparatus comprising a reading unit adapted for reading magnetic data recorded on a magnetic card and for outputting a reproduction signal, comprising a decoding unit adapted for determining the presence of a detection pulse for every predetermined cycle to decode the reproduction signal outputted from the reading unit to binary data; characterised in that the card insertion detection unit further comprises a conversion portion adapted for irreversibly converting the magnetic data read from the magnetic card by extracting predetermined data from the data decoded by the decoding unit; and an output unit adapted for outputting the data irreversibly converted by the conversion portion, wherein the data is used to determine whether the magnetic card is inserted or not.
End closure for a superconducting cable, which is arranged in a tubular cryostat serving to guide a coolant, and at least one electrical conductor, wherein the end closure has an inner sheath, in which one end of the cable is disposed in a coolant, and an outer sheath, wherein the sheaths (3, 4) are made of electrically insulating material and are arranged in a space between the inner and the outer sheath of insulating material, wherein the inner sheath is connectable to the cryostat, and wherein the end closure is arranged vertically in its mounting position, so that, in the operating state, a lower part of the inner and outer sheath is earthed, while an upper part of the inner and outer sheath is connected to high voltage potential, characterized in that at their respective upper ends, the inner sheath is closed with a first bursting disk, while the outer sheath is closed with a second bursting disk.
Electrically heated vessel, comprising a container space for containing liquid, a heating element for supplying heat to the container space, and a seal, which seal is positioned inside the vessel for protecting a portion of the vessel which is present at a side of the heating element facing away from the container space from penetration of liquid from the container space, and which seal has an annular shape, and comprises at least one resilient circumferential projection extending outwardly, characterised in that the projection has at least one discontinuity in its surface.
A domestic oven having at least one cooking chamber encircled by an outer body; a door providing access to the cooking chamber in an open position; and a lock mechanism providing locking of said door in a closed position, wherein the lock mechanism of the domestic oven comprises a triggering element which activates a lock, which is in locked position, in a releasable manner, and which is placed on a door lever in a hidden manner on an accessible side of an outer wall of the door and wherein the lock mechanism comprises a housing element providing placement of the triggering element on an accessible side of the outer wall, characterized in that the housing element - comprises a groove formed so as to face the outer wall and wherein the triggering element is positioned, - comprises a bearing extension through which a channel of the triggering element passes so that the triggering element is fixed, wherein the triggering element is fixed on the bearing extension in a manner moving in the triggering direction (b) and in the inverse direction, - comprises a slit through which a trigger latch of the triggering element passes, wherein since the trigger latch extends outwardly from the slit for providing access to the trigger latch, the width of the slit provides a trigger movement clearance (a) for the trigger latch. - comprises a groove formed so as to face the outer wall and wherein the triggering element is positioned, - comprises a bearing extension through which a channel of the triggering element passes so that the triggering element is fixed, wherein the triggering element is fixed on the bearing extension in a manner moving in the triggering direction (b) and in the inverse direction, - comprises a slit through which a trigger latch of the triggering element passes, wherein since the trigger latch extends outwardly from the slit for providing access to the trigger latch, the width of the slit provides a trigger movement clearance (a) for the trigger latch.
Radome comprising a composite structure having an external surface capable of being subjected to an airflow, said structure comprising a lightning-arresting system comprising at least one part that is made of an insulating composite and that is inserted into the thickness of the composite structure, the part forming an integral portion of the composite structure and having a recessed profile and at least one electrically conductive strip positioned in the recessed profile and fasteners fastening said strip to the structure, said strip being capable of being electrically connected, by conductive elements, to a ground allowing the evacuation of currents, said strip having a shape intended to interact with the recessed profile produced in said external surface so that the external surface of the strip is flush with said external surface of the structure, and in that said fasteners include an upper portion that is flush with the external surface of the strip.
A method of dispensing a fluid, the method comprising: charging a fluid to a pressure with a prime mover; cycling a downstream valve open and closed at a fixed frequency; varying a valve-open time to maintain a desired flow rate at a downstream dispenser; sensing the valve-open time; and controlling the prime mover to alter the pressure generated by the prime mover such that the pressure is increased as the valve-open time approaches 100 percent of the frequency, and the pressure is decreased as the valve-open time approaches zero percent of the frequency. charging a fluid to a pressure with a prime mover; cycling a downstream valve open and closed at a fixed frequency; varying a valve-open time to maintain a desired flow rate at a downstream dispenser; sensing the valve-open time; and controlling the prime mover to alter the pressure generated by the prime mover such that the pressure is increased as the valve-open time approaches 100 percent of the frequency, and the pressure is decreased as the valve-open time approaches zero percent of the frequency.
A filling machine for the hot filling of containers with food-type liquids, which comprises a line for feeding the containers to be filled to at least one supporting plate and a line for unloading the filled container from said supporting plate, above said at least one supporting plate there being a filling head, which is associated with a respective valve assembly which is adapted to convey the liquid from a containment tank into the container to be filled, said valve assembly being associated with a feeder conduit which is internally hollow and is associated with a suction conduit which is provided with at least one suction inlet which is designed to determine the level of the liquid inside said container, said feeder conduit being functionally associated with a flow control element, said filling head comprising a sealing element which has a first sealing body which defines a chamber and is designed to engage hermetically against the upper edge of said container, the first sealing body being associated with a vent which is adapted to pass between a position for sealing the chamber for passing liquid from said supply feeder conduit toward said container and a position for venting in which at least one port is defined for the passage of air from said chamber for passing liquid toward the outside, means being provided for actuating the suction of the liquid from said container by way of said suction conduit which are functionally associated with a device for activating said vent from said position for sealing to said position for venting, said filling machine being characterized by comprising an element for moving said suction conduit between an inactive position, in which it is arranged with its lower edge above the lower edge of said first sealing body, and an active position, in which said lower edge of said suction conduit is arranged below the lower edge of said first sealing body.
Thread-laying device for use during the manufacture of a bobbin wound with a yarn, which has a spool shaft extending along a bobbin longitudinal axis and a conical foot disk located at the spool shaft, with a bobbin support and with a yarn guide, which abuts against the bobbin or against a yarn layer located on the bobbin during winding, wherein the yarn can be wound on the bobbin by means of the yarn guide in axially displaced yarn layers and wherein a control means is provided for controlling the winding process, wherein the yarn guide can be moved back and forth relative to the bobbin support by means of an oscillating movement along the bobbin longitudinal axis for forming the respective yarn layers, wherein a foot disk-sided end position of the oscillating movement of the yarn guide and the foot plate of the bobbin can be advanced relative to one another during the winding process along the bobbin longitudinal axis by a feed motion of the yarn guide, superimposed on the oscillating movement of the yarn guide and the bobbin, characterized in that the control equipment is programmed to control or regulate the oscillating movement of the yarn guide depending on the feed motion of the yarn guide and the bobbin relative to one another such that the relative speed of the yarn guide resulting from the oscillating movement and the feed motion in relation to the bobbin is kept constant.
A vehicle steering system transmission comprising: a driver connected to a driver shaft having an input sprocket; the driver shaft connected to an output shaft by a first linkage, the first linkage comprising a first intermediate shaft having a first sprocket and a second sprocket, where the first sprocket of the first intermediate shaft is connected to the driver shaft by a first flexible link; a first sensor mounted to the driver shaft and for sensing the driver shaft; and a control unit receiving a signal from the first sensor, the control unit transmitting a signal to the driver to control an output shaft movement; characterized in that: the first sensor is for sensing the driver shaft angular position; the first linkage further comprises: a second intermediate shaft having a third sprocket and a fourth sprocket, where the third sprocket of the second intermediate shaft is connected to the second sprocket of the first intermediate shaft by a second flexible link, and the fourth sprocket of the second intermediate shaft is connected to the output shaft by a belt; and further comprising: a second sensor mounted to the first intermediate shaft and for sensing the first intermediate shaft angular position; and a third sensor mounted to the second intermediate shaft and for sensing the second intermediate shaft angular position; the second sensor and the third sensor for transmitting a signal to the control unit. a driver connected to a driver shaft having an input sprocket; the driver shaft connected to an output shaft by a first linkage, the first linkage comprising a first intermediate shaft having a first sprocket and a second sprocket, where the first sprocket of the first intermediate shaft is connected to the driver shaft by a first flexible link; a first sensor mounted to the driver shaft and for sensing the driver shaft; and a control unit receiving a signal from the first sensor, the control unit transmitting a signal to the driver to control an output shaft movement; the first sensor is for sensing the driver shaft angular position; the first linkage further comprises: a second intermediate shaft having a third sprocket and a fourth sprocket, where the third sprocket of the second intermediate shaft is connected to the second sprocket of the first intermediate shaft by a second flexible link, and the fourth sprocket of the second intermediate shaft is connected to the output shaft by a belt; and further comprising: a second sensor mounted to the first intermediate shaft and for sensing the first intermediate shaft angular position; and a third sensor mounted to the second intermediate shaft and for sensing the second intermediate shaft angular position; the second sensor and the third sensor for transmitting a signal to the control unit.
A computer-implemented method for detecting somatic single nucleotide variants (SNVs) from cell-free deoxyribonucleic acid (cfDNA), the method comprising the steps of: a) estimating, for a set of sequence data from a cfDNA sample, an estimated global tumor cfDNA fraction by maximizing a likelihood of observing the set of sequence data at a plurality of potential SNV sites in the set of sequence data; b) determining, for at least one potential SNV site in the set of sequencing data, a genotype likelihood based at least in part on the estimated global tumor cfDNA fraction; c) eliminating, from the set of sequence data, germline polymorphism based at least in part on the genotype likelihood to detect a plurality of somatic SNV candidates; d) filtering the plurality of somatic SNV candidates by a set of filters to output a plurality of filtered somatic SNV candidates; and e) analyzing, using a probabilistic model that incorporates the estimated global tumor cfDNA fraction and the filtered somatic SNV candidates, the set of sequence data to determine a fraction of tumor-derived DNA (ctDNA) in the cfDNA sample. a) estimating, for a set of sequence data from a cfDNA sample, an estimated global tumor cfDNA fraction by maximizing a likelihood of observing the set of sequence data at a plurality of potential SNV sites in the set of sequence data; b) determining, for at least one potential SNV site in the set of sequencing data, a genotype likelihood based at least in part on the estimated global tumor cfDNA fraction; c) eliminating, from the set of sequence data, germline polymorphism based at least in part on the genotype likelihood to detect a plurality of somatic SNV candidates; d) filtering the plurality of somatic SNV candidates by a set of filters to output a plurality of filtered somatic SNV candidates; and e) analyzing, using a probabilistic model that incorporates the estimated global tumor cfDNA fraction and the filtered somatic SNV candidates, the set of sequence data to determine a fraction of tumor-derived DNA (ctDNA) in the cfDNA sample.