A compound of Formula: or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof; wherein: B ring is X 1 and X 4 are each independently C or N; X 2 and X 3 are each independently CR 3, N, NR 4, O, or S; E 1, E 2 and E 3 together form a moiety selected from L 1 is a covalent bond, Z is benzo[d]thiazolyl, isoquinolinyl, phenyl, pyrazolyl, pyridinyl, or quinolinyl, each substituted with zero to 3 R 10; L 2 is a covalent bond; R X is -C OH, -C NH 2, -C NHS 2 CH 3, -CH 2 C OH, or -C OCH 3; R Z is selected from -CN, -OH, -C OR 13, -C NR 14a R 14b, R e is C 1-6 alkyl, C 3-6 cycloalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, or phenyl; R 1 is cyclopropyl; R 2 is phenyl or pyridinyl, each independently substituted with 0 to 3 R 16, R 3 is hydrogen, halo, cyano, hydroxyl, amino, C 1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy; R 4, is hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, or haloalkoxyalkyl; a is an integer of 0, 1, 2, or 3; R 10 is independently F, Cl, -CH 3, -CH 2 CH 3, -CF 3, -OCH 3, -OCH 2 CH 3, -OCH(CH 3) 2, -OCHF 2, -OCF 3, -O(C 3-5 cycloalkyl), or cyclopropyl; R 16 is F, Cl, -CH 3, -CF 3, -OCH 3, or -OCF 3; R a is selected from C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl; R 13 is hydrogen, C 1-10 alkyl, or glycosyl; and R 14a and R 14b are each independently hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy. B ring is X 1 and X 4 are each independently C or N; X 2 and X 3 are each independently CR 3, N, NR 4, O, or S; E 1, E 2 and E 3 together form a moiety selected from L 1 is a covalent bond, Z is benzo[d]thiazolyl, isoquinolinyl, phenyl, pyrazolyl, pyridinyl, or quinolinyl, each substituted with zero to 3 R 10; L 2 is a covalent bond; R X is -C OH, -C NH 2, -C NHS 2 CH 3, -CH 2 C OH, or -C OCH 3; R Z is selected from -CN, -OH, -C OR 13, -C NR 14a R 14b, R e is C 1-6 alkyl, C 3-6 cycloalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, or phenyl; R 1 is cyclopropyl; R 2 is phenyl or pyridinyl, each independently substituted with 0 to 3 R 16, R 3 is hydrogen, halo, cyano, hydroxyl, amino, C 1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy; R 4, is hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, or haloalkoxyalkyl; a is an integer of 0, 1, 2, or 3; R 10 is independently F, Cl, -CH 3, -CH 2 CH 3, -CF 3, -OCH 3, -OCH 2 CH 3, -OCH(CH 3) 2, -OCHF 2, -OCF 3, -O(C 3-5 cycloalkyl), or cyclopropyl; R 16 is F, Cl, -CH 3, -CF 3, -OCH 3, or -OCF 3; R a is selected from C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl; R 13 is hydrogen, C 1-10 alkyl, or glycosyl; and R 14a and R 14b are each independently hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy.