mhurhangee/ep-ind-claims huggingface dataset:
An apparatus configured to perform an assay on assay sites of an assay consumable, the apparatus comprising: an assay consumable handler configured to be operatively coupled to the assay consumable having a surface comprising assay sites; a sealer constructed and positioned to apply a sealing component to the surface of the assay consumable, the sealing component comprising a sealing liquid; a sample loader configured to load an assay sample into at least a portion of the plurality of assay sites of the assay consumable; an imaging system configured to acquire an image of at least a portion of the assay sites of the assay consumable containing assay sample; and a computer implemented control system configured to automatically operate the sealer and receive information from the imaging system related to the image, the assay consumable operatively coupled to the assay consumable handler, wherein the assay sites have a volume between about 10 attoliters and about 50 picoliters; and the assay consumable comprises fluidically isolated areas, each fluidically isolated area comprising a plurality of the assay sites, wherein the fluidically isolated areas are situated on a disc; wherein the sealer, the sample loader, and the imaging system are arranged to be positioned about the disc, and wherein the apparatus is capable of providing rotational relative motion between the assay consumable and the sealer, the sample loader, and the imaging system. an assay consumable handler configured to be operatively coupled to the assay consumable having a surface comprising assay sites; a sealer constructed and positioned to apply a sealing component to the surface of the assay consumable, the sealing component comprising a sealing liquid; a sample loader configured to load an assay sample into at least a portion of the plurality of assay sites of the assay consumable; an imaging system configured to acquire an image of at least a portion of the assay sites of the assay consumable containing assay sample; and a computer implemented control system configured to automatically operate the sealer and receive information from the imaging system related to the image, the assay consumable operatively coupled to the assay consumable handler, wherein the assay sites have a volume between about 10 attoliters and about 50 picoliters; and the assay consumable comprises fluidically isolated areas, each fluidically isolated area comprising a plurality of the assay sites, wherein the fluidically isolated areas are situated on a disc; the assay sites have a volume between about 10 attoliters and about 50 picoliters; and the assay consumable comprises fluidically isolated areas, each fluidically isolated area comprising a plurality of the assay sites, wherein the fluidically isolated areas are situated on a disc; wherein the sealer, the sample loader, and the imaging system are arranged to be positioned about the disc, and wherein the apparatus is capable of providing rotational relative motion between the assay consumable and the sealer, the sample loader, and the imaging system.
Synchronization method for a master sensor and at least one slave sensor, for synchronized recording of at least one sensor value by the at least one slave sensor in relation to an intended value of the master sensor to be predetermined, comprising a: • collection of a first time/measured value pair by the master sensor at a first time, • collection of at least a second time/measured value pair by the master sensor at a second time, • provision of an extrapolation rule by calculation from the first time/measured value pair and at least the second time/measured value pair, • provision of an extrapolated time associated with a predetermined intended value of the master sensor, on the basis of the extrapolation rule, • transmission of a first synchronization signal to the at least one slave sensor when the extrapolated time occurs and/or when a delay time, different from the extrapolated time in a temporally defined manner, occurs, • triggering of a recording of at least one slave sensor value by the first synchronization signal and • provision of the intended value and the at least one slave sensor value as connected value tuple. • collection of a first time/measured value pair by the master sensor at a first time, • collection of at least a second time/measured value pair by the master sensor at a second time, • provision of an extrapolation rule by calculation from the first time/measured value pair and at least the second time/measured value pair, • provision of an extrapolated time associated with a predetermined intended value of the master sensor, on the basis of the extrapolation rule, • transmission of a first synchronization signal to the at least one slave sensor when the extrapolated time occurs and/or when a delay time, different from the extrapolated time in a temporally defined manner, occurs, • triggering of a recording of at least one slave sensor value by the first synchronization signal and • provision of the intended value and the at least one slave sensor value as connected value tuple.
A combination of an airbag deployment control system for use in a vehicle seat and a trim cover defining a burst seam for an airbag member to deploy through upon inflation of the airbag member, the airbag deployment control system comprising: an upper outer liner member having a first end for coupling to an airbag module and a second opposite end for coupling to the trim cover, and a lower outer liner member having a first end for coupling to the airbag module and a second opposite end for coupling to the trim cover; and wherein the upper outer liner member and the lower outer liner member are configured to control deployment of the inflatable airbag member in at least two locations and direct the deployment of the inflatable airbag member towards the burst seam upon inflation of the airbag member. an upper outer liner member having a first end for coupling to an airbag module and a second opposite end for coupling to the trim cover, and a lower outer liner member having a first end for coupling to the airbag module and a second opposite end for coupling to the trim cover; and wherein the upper outer liner member and the lower outer liner member are configured to control deployment of the inflatable airbag member in at least two locations and direct the deployment of the inflatable airbag member towards the burst seam upon inflation of the airbag member.
A composition comprising an effective amount of 10-propargyl-10-deazaaminopterin or its pharmaceutically acceptable salts for use in treating a methotrexate-resistant disorder in an individual having a methotrexate-resistant disorder, wherein the methotrexate-resistant disorder is an acquired methotrexate-resistant disorder.
A diagnostic ultrasound system for assessing regurgitant flow comprising: - an ultrasound probe having a transducer array configured for transmitting ultrasonic energy to, and receiving ultrasonic echoes from, a location of regurgitant flow in a body; - an image processor, responsive to received echoes, configured for producing an ultrasound image of the location of regurgitant flow; - a Doppler processor, responsive to received echoes, configured for producing Doppler ultrasound measurements of blood flow velocity in the vicinity of the location of regurgitant flow; and a user control; characterized in that the ultrasound system further comprises: - a flow quantification processor, responsive to blood flow velocity measurements in the vicinity of a regurgitant orifice, configured to produce calculated location coordinates of the orifice, wherein the flow quantification processor is responsive to an initial estimate of the location of the orifice and to flow velocity estimates to iteratively refine by use of a flow velocity field model the location coordinates of the orifice; and - an ultrasound image display, responsive to the image processor and the flow quantification processor, configured to display an indication of the location of the orifice in an ultrasound image at the calculated location coordinates; wherein the user control is operable by a user to indicate the initial estimate of the location of the orifice in the ultrasound image and wherein the flow quantification processor is responsive to said indicated initial estimate to produce the calculated location coordinates of the orifice. - an ultrasound probe having a transducer array configured for transmitting ultrasonic energy to, and receiving ultrasonic echoes from, a location of regurgitant flow in a body; - an image processor, responsive to received echoes, configured for producing an ultrasound image of the location of regurgitant flow; - a Doppler processor, responsive to received echoes, configured for producing Doppler ultrasound measurements of blood flow velocity in the vicinity of the location of regurgitant flow; and - a flow quantification processor, responsive to blood flow velocity measurements in the vicinity of a regurgitant orifice, configured to produce calculated location coordinates of the orifice, wherein the flow quantification processor is responsive to an initial estimate of the location of the orifice and to flow velocity estimates to iteratively refine by use of a flow velocity field model the location coordinates of the orifice; and - an ultrasound image display, responsive to the image processor and the flow quantification processor, configured to display an indication of the location of the orifice in an ultrasound image at the calculated location coordinates;
Quartz glass crucible for pulling a silicon single crystal, comprising a straight body part and a bottom part, said quartz glass crucible for pulling a silicon single crystal being characterized in that a fictive temperature gradient is formed over the thickness of the crucible wall on at least the abovementioned straight body part, and the outermost fictive temperature is made to be at least 50°C lower than the innermost fictive temperature.
A scanning system for incising target tissue in a patient's eye, the scanning system comprising: an ultrafast laser light source configured to deliver a laser beam comprising a plurality of laser pulses; an Optical Coherence Tomography device configured to generate signals that can be used to create an image of eye tissue that includes a cornea, a limbus and sclera of the patient's eye; a scanner (40, 50) configured to direct the laser beam to different locations within the patient's eye; and a controller operatively coupled to the laser source, the OCT device, and the scanner, and configured to: (a) operate the OCT device to scan the eye tissue to generate imaging data for the target tissue; (b) control the formation of a first treatment pattern by the scanner in response to the generated imaging data, so that the laser beam incises a cataract incision in the cornea or limbus that provides access to an eye chamber of the patient's eye, wherein the cataract incision comprises a bevel feature, and to control the formation of a second treatment pattern by the scanner in response to the imaging data so that the laser beam incises one or more relaxation incisions along limbus tissue or along corneal tissue anterior to the limbus to reduce astigmatism; wherein the scanning system further comprises a delivery system arranged downstream of the scanner for delivering the first and second treatment patterns to the target tissue. an ultrafast laser light source configured to deliver a laser beam comprising a plurality of laser pulses; an Optical Coherence Tomography device configured to generate signals that can be used to create an image of eye tissue that includes a cornea, a limbus and sclera of the patient's eye; a scanner (40, 50) configured to direct the laser beam to different locations within the patient's eye; and a controller operatively coupled to the laser source, the OCT device, and the scanner, and configured to: (a) operate the OCT device to scan the eye tissue to generate imaging data for the target tissue; (b) control the formation of a first treatment pattern by the scanner in response to the generated imaging data, so that the laser beam incises a cataract incision in the cornea or limbus that provides access to an eye chamber of the patient's eye, wherein the cataract incision comprises a bevel feature, and to control the formation of a second treatment pattern by the scanner in response to the imaging data so that the laser beam incises one or more relaxation incisions along limbus tissue or along corneal tissue anterior to the limbus to reduce astigmatism; (a) operate the OCT device to scan the eye tissue to generate imaging data for the target tissue; (b) control the formation of a first treatment pattern by the scanner in response to the generated imaging data, so that the laser beam incises a cataract incision in the cornea or limbus that provides access to an eye chamber of the patient's eye, wherein the cataract incision comprises a bevel feature, and wherein the scanning system further comprises a delivery system arranged downstream of the scanner for delivering the first and second treatment patterns to the target tissue.
Circuitry for an implantable neurostimulator device having a plurality of electrodes, comprising: a first multiplexer configured to select from at least the plurality of electrodes and for producing a first output; a second multiplexer configured to select from at least the plurality of electrodes and for producing a second output; and holding circuitry for receiving the first output and the second output and for producing a first voltage and a second voltage; characterised in that the holding circuitry comprises a first and a second capacitor, wherein the first capacitor is configured to store a difference in voltage between the first and second outputs during a first stage occurring during a first phase of a pulse, and wherein the second capacitor is configured to store a difference in voltage between the first and second outputs during a second stage occurring during a second phase of the pulse, and wherein the holding circuitry is further configured to connect the first and second capacitors in series during a third stage occurring during a third phase of the pulse, and wherein the first and second voltages are connected to the ends of the serial connection of the first and second capacitors, and wherein the circuitry further comprises an amplifier for outputting a differe between the first voltage and the second voltage. a first multiplexer configured to select from at least the plurality of electrodes and for producing a first output; a second multiplexer configured to select from at least the plurality of electrodes and for producing a second output; and holding circuitry for receiving the first output and the second output and for producing a first voltage and a second voltage; characterised in that the holding circuitry comprises a first and a second capacitor, wherein the first capacitor is configured to store a difference in voltage between the first and second outputs during a first stage occurring during a first phase of a pulse, and wherein the second capacitor is configured to store a difference in voltage between the first and second outputs during a second stage occurring during a second phase of the pulse, and wherein the holding circuitry is further configured to connect the first and second capacitors in series during a third stage occurring during a third phase of the pulse, and wherein the first and second voltages are connected to the ends of the serial connection of the first and second capacitors, and wherein the circuitry further comprises an amplifier for outputting a differe between the first voltage and the second voltage.
Middle support for a building opening with a large clearance with at least two rolling doors and/or roll-up grates provided thereon, for supporting and laterally guiding adjacent doors or grates, comprising a base body which is an elongated extruded profile, and a locking device with at least one locking rod (30, 34) and a locking rod guide (32, 36), characterized in that the locking rod guide (32, 36) comprises a cover plate which is fixed on an end face of the extruded profile, wherein the end face is the upper side face and/or the lower side face of the elongated extruded profile when used as intended.
A compound of the formula: or a pharmaceutically acceptable salt thereof, for use in the treatment of non-small cell lung cancer in combination with an antibody comprising a light chain variable region (LCVR) whose amino acid sequence is that given in SEQ ID NO: 2, and a heavy chain variable region (HCVR) whose amino acid sequence is that given in SEQ ID NO: 4, wherein that the antibody binds to VEGFR2.
An antenna device (600, 1000, 1400), comprising: an end-fire antenna array, the end-fire antenna array comprising a ground member including a plane part and a plurality of extension parts (611-614, 1011-1014, 1411-1414) extending from one end of the plane part in a first direction and arranged along a second direction; a plurality of patch-type radiators (630, 1030, 1430) arranged on the plane part along the second direction and configured mainly to radiate vertical polarization in the first direction; and a plurality of straight radiators (650, 1050, 1450) spaced apart from the ground member, respectively arranged to be adjacent to the plurality of extension parts (611-614, 1011-1014, 1411-1414) extending in the first direction, and configured mainly to radiate horizontal polarization in the first direction; wherein one or more slits (660, 1060, 1460) are formed in the plane part, and wherein the one or more slits (660, 1060, 1460) are positioned in gaps between the plurality of extension parts (611-614, 1011-1014, 1411-1414), respectively. an end-fire antenna array, the end-fire antenna array comprising a ground member including a plane part and a plurality of extension parts (611-614, 1011-1014, 1411-1414) extending from one end of the plane part in a first direction and arranged along a second direction; a plurality of patch-type radiators (630, 1030, 1430) arranged on the plane part along the second direction and configured mainly to radiate vertical polarization in the first direction; and a plurality of straight radiators (650, 1050, 1450) spaced apart from the ground member, respectively arranged to be adjacent to the plurality of extension parts (611-614, 1011-1014, 1411-1414) extending in the first direction, and configured mainly to radiate horizontal polarization in the first direction; wherein one or more slits (660, 1060, 1460) are formed in the plane part, and wherein the one or more slits (660, 1060, 1460) are positioned in gaps between the plurality of extension parts (611-614, 1011-1014, 1411-1414), respectively.
A method for plasma dicing a substrate, the method comprising: providing a process chamber having a wall; providing a plasma source adjacent to the wall of the process chamber; providing a work piece support within the process chamber; placing the substrate onto a support film on a rigid frame with an intermediate ring to form a work piece wherein the intermediate ring does not overlap the substrate and there is no contact between the intermediate ring and the substrate; placing the work piece onto the work piece support; generating a plasma through the plasma source; and processing the substrate by exposing the substrate of the work piece to the generated plasma; modifying the work piece by removing the rigid frame once the substrate has been at least partially processed; and sending the modified work piece downstream for further processing. providing a process chamber having a wall; providing a plasma source adjacent to the wall of the process chamber; providing a work piece support within the process chamber; placing the substrate onto a support film on a rigid frame with an intermediate ring to form a work piece wherein the intermediate ring does not overlap the substrate and there is no contact between the intermediate ring and the substrate; placing the work piece onto the work piece support; generating a plasma through the plasma source; and processing the substrate by exposing the substrate of the work piece to the generated plasma; modifying the work piece by removing the rigid frame once the substrate has been at least partially processed; and sending the modified work piece downstream for further processing.
A combustion installation for combusting liquid, solid or gaseous fuels, comprising a combustion chamber with a fuel feed and a combustion air feed, a flue gas path (2, 3, 3', 4, 4', 4", 5, 6, 6') and a heat accumulator, wherein the combustion installation is configured in a way that, in an operating state in which fuel combustion inside the combustion chamber is taking place, to conduct at least part of the thermal energy of the flue gas (2, 3) conducted out of the combustion chamber into the heat accumulator, and the heat accumulator is configured to store the thermal energy, characterized in that said combustion installation is further configured, in an operating state in which combustion inside the combustion chamber is turned off, to transfer thermal energy from the heat accumulator into the combustion chamber, wherein the entry of the thermal energy into the combustion chamber occurs by way of a gaseous heat carrier medium (10, 10'), preferably air.
An isolated immunogenic peptide comprising: - an MHC class II T cell epitope of an auto-antigen protein involved in multiple sclerosis; and - a C-X - or -X -C redox motif, said motif being either adjacent to said epitope, or separated from said epitope by at most 7 amino acids. - an MHC class II T cell epitope of an auto-antigen protein involved in multiple sclerosis; and - a C-X - or -X -C redox motif, said motif being either adjacent to said epitope, or separated from said epitope by at most 7 amino acids.
A refrigerating machine including a compressor, an evaporator and a condenser, the compressor being adapted to compress refrigerant gas evaporated in the evaporator to convey the compressed refrigerant gas to the condenser, the compressor comprising: a motor; a housing having a compression chamber inside; a rotary member which has a rotating shaft and is rotated by a driving force of the motor so as to compress water vapor serving as the refrigerant gas in the compression chamber; a bearing (26, 26, 26) for supporting the rotating shaft of the rotary member in the housing; and a lubricant supplier for supplying water serving as a lubricant to the bearing (26, 26, 26), characterized in that the refrigerating machine is provided with a coolant supplying line configured to supply coolant water to the condenser; the lubricant supplier includes a lubricant supplying line connecting the bearing (26, 26, 26) with the coolant supplying line. a motor; a housing having a compression chamber inside; a rotary member which has a rotating shaft and is rotated by a driving force of the motor so as to compress water vapor serving as the refrigerant gas in the compression chamber; a bearing (26, 26, 26) for supporting the rotating shaft of the rotary member in the housing; and a lubricant supplier for supplying water serving as a lubricant to the bearing (26, 26, 26), characterized in that the refrigerating machine is provided with a coolant supplying line configured to supply coolant water to the condenser; the lubricant supplier includes a lubricant supplying line connecting the bearing (26, 26, 26) with the coolant supplying line.