A crude oil refinery pre-heat train, i.e., PHT, comprising: a crude oil stream pipeline system that extends through the PHT and is configured to carry a stream of crude oil from an inlet of the PHT to a furnace of the PHT; a plurality of heat exchangers positioned in the crude oil stream pipeline system, the plurality of heat exchangers comprising a first set of heat exchangers (108a, 110a, 110b, 110c, 110d, 110e, 112a) positioned in the crude oil stream pipeline system in a first section (102, 405) of the PHT, the first section comprising a portion of the PHT between the inlet of the PHT and one or more de-salters of the PHT, a second set of heat exchangers (116a, 116b, 112b, 112c, 114b, 114c, 116c) positioned in the crude oil stream pipeline system in a second section (104, 410) of the PHT, the second section comprising a portion of the PHT after the one or more de-salters of the PHT and before one or more pre-flash drums of the PHT, and a third set of heat exchangers (116d, 108b, 116e, 118a, 118b, 118c, 116f, 116g, 116h, 116i, 112d, 112e, 112f, 118d, 116j) positioned in the crude oil stream pipeline system in a third section (106, 415) of the PHT, the third section comprising a portion of the PHT after the one or more pre-flash drums of the PHT and before the furnace of the PHT; and a control system configured to actuate a first plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the first section of the PHT, the control system also configured to actuate a second plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the second section of the PHT, the control system also configured to actuate a third plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the third section of the PHT. a crude oil stream pipeline system that extends through the PHT and is configured to carry a stream of crude oil from an inlet of the PHT to a furnace of the PHT; a plurality of heat exchangers positioned in the crude oil stream pipeline system, the plurality of heat exchangers comprising a first set of heat exchangers (108a, 110a, 110b, 110c, 110d, 110e, 112a) positioned in the crude oil stream pipeline system in a first section (102, 405) of the PHT, the first section comprising a portion of the PHT between the inlet of the PHT and one or more de-salters of the PHT, a second set of heat exchangers (116a, 116b, 112b, 112c, 114b, 114c, 116c) positioned in the crude oil stream pipeline system in a second section (104, 410) of the PHT, the second section comprising a portion of the PHT after the one or more de-salters of the PHT and before one or more pre-flash drums of the PHT, and a third set of heat exchangers (116d, 108b, 116e, 118a, 118b, 118c, 116f, 116g, 116h, 116i, 112d, 112e, 112f, 118d, 116j) positioned in the crude oil stream pipeline system in a third section (106, 415) of the PHT, the third section comprising a portion of the PHT after the one or more pre-flash drums of the PHT and before the furnace of the PHT; and a control system configured to actuate a first plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the first section of the PHT, the control system also configured to actuate a second plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the second section of the PHT, the control system also configured to actuate a third plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the third section of the PHT. a first set of heat exchangers (108a, 110a, 110b, 110c, 110d, 110e, 112a) positioned in the crude oil stream pipeline system in a first section (102, 405) of the PHT, the first section comprising a portion of the PHT between the inlet of the PHT and one or more de-salters of the PHT, a second set of heat exchangers (116a, 116b, 112b, 112c, 114b, 114c, 116c) positioned in the crude oil stream pipeline system in a second section (104, 410) of the PHT, the second section comprising a portion of the PHT after the one or more de-salters of the PHT and before one or more pre-flash drums of the PHT, and a third set of heat exchangers (116d, 108b, 116e, 118a, 118b, 118c, 116f, 116g, 116h, 116i, 112d, 112e, 112f, 118d, 116j) positioned in the crude oil stream pipeline system in a third section (106, 415) of the PHT, the third section comprising a portion of the PHT after the one or more pre-flash drums of the PHT and before the furnace of the PHT; and a control system configured to actuate a first plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the first section of the PHT, the control system also configured to actuate a second plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the second section of the PHT, the control system also configured to actuate a third plurality of control valves to selectively thermally couple the crude oil stream with a plurality of heat sources in the third section of the PHT.