A compound of general formula and pharmaceutically acceptable salts and solvates thereof wherein R 1 is ▪ halogen; ▪ vinylene-aryl; ▪ aryl, which is substituted with one or more substituent selected from the following group: - alkoxy which is optionally substituted with one or more halogen or with aryl which is optionally substituted with one or more halogen, alkyl or alkoxy, preferably with alkoxy, - halogen, - alkyl which is optionally substituted with one or more halogen or alkoxy, preferably with halogen, - alkylaryloxy which is optionally substituted with alkoxy which is optionally substituted with one or more halogen, - aminocarbonyl, - amino, which is optionally substituted with one or two alkyl; - alkylthio, - alkylsulfinyl or alkylsulfonyl, - aryloxy, - hydroxyl; ▪ group of formula (a) wherein m is 1, 2 or 3 and R' is hydrogen, halogen, alkyl or alkoxy; ▪ heteroaryl; W is a ▪ group of formula (b) wherein R 2 stands for - alkyl, alkoxy or aryl, which groups are optionally substituted with one or more halogen, - heteroaryl, - benzyl, which is optionally substituted with one or more halogen, alkyl or alkoxy, - amino, which is optionally substituted with one or two alkyl; ▪ heteroaryl group, which is optionally substituted with a (CH 2) k -heterocycloalkyl group, where k is 0, 1, 2 or 3; ▪ NH-R 3, wherein R 3 is hydrogen, alkyl, alkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aminoalkyl, aminoaryl or aminoheteroaryl, or R 3 is -CO-aryl, -CO-NH-aryl where the aryl is optionally substituted with one or more halogen; and n is 1, 2, 3 or 4. R 1 is ▪ halogen; ▪ vinylene-aryl; ▪ aryl, which is substituted with one or more substituent selected from the following group: - alkoxy which is optionally substituted with one or more halogen or with aryl which is optionally substituted with one or more halogen, alkyl or alkoxy, preferably with alkoxy, - halogen, - alkyl which is optionally substituted with one or more halogen or alkoxy, preferably with halogen, - alkylaryloxy which is optionally substituted with alkoxy which is optionally substituted with one or more halogen, - aminocarbonyl, - amino, which is optionally substituted with one or two alkyl; - alkylthio, - alkylsulfinyl or alkylsulfonyl, - aryloxy, - hydroxyl; ▪ group of formula (a) wherein m is 1, 2 or 3 and R' is hydrogen, halogen, alkyl or alkoxy; ▪ heteroaryl; ▪ halogen; ▪ vinylene-aryl; ▪ aryl, which is substituted with one or more substituent selected from the following group: - alkoxy which is optionally substituted with one or more halogen or with aryl which is optionally substituted with one or more halogen, alkyl or alkoxy, preferably with alkoxy, - halogen, - alkyl which is optionally substituted with one or more halogen or alkoxy, preferably with halogen, - alkylaryloxy which is optionally substituted with alkoxy which is optionally substituted with one or more halogen, - aminocarbonyl, - amino, which is optionally substituted with one or two alkyl; - alkylthio, - alkylsulfinyl or alkylsulfonyl, - aryloxy, - hydroxyl; - alkoxy which is optionally substituted with one or more halogen or with aryl which is optionally substituted with one or more halogen, alkyl or alkoxy, preferably with alkoxy, - halogen, - alkyl which is optionally substituted with one or more halogen or alkoxy, preferably with halogen, - alkylaryloxy which is optionally substituted with alkoxy which is optionally substituted with one or more halogen, - aminocarbonyl, - amino, which is optionally substituted with one or two alkyl; - alkylthio, - alkylsulfinyl or alkylsulfonyl, - aryloxy, - hydroxyl; ▪ group of formula (a) wherein m is 1, 2 or 3 and R' is hydrogen, halogen, alkyl or alkoxy; ▪ heteroaryl; W is a ▪ group of formula (b) wherein R 2 stands for - alkyl, alkoxy or aryl, which groups are optionally substituted with one or more halogen, - heteroaryl, - benzyl, which is optionally substituted with one or more halogen, alkyl or alkoxy, - amino, which is optionally substituted with one or two alkyl; ▪ heteroaryl group, which is optionally substituted with a (CH 2) k -heterocycloalkyl group, where k is 0, 1, 2 or 3; ▪ NH-R 3, wherein R 3 is hydrogen, alkyl, alkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aminoalkyl, aminoaryl or aminoheteroaryl, or R 3 is -CO-aryl, -CO-NH-aryl where the aryl is optionally substituted with one or more halogen; and ▪ group of formula (b) wherein R 2 stands for - alkyl, alkoxy or aryl, which groups are optionally substituted with one or more halogen, - heteroaryl, - benzyl, which is optionally substituted with one or more halogen, alkyl or alkoxy, - amino, which is optionally substituted with one or two alkyl; - alkyl, alkoxy or aryl, which groups are optionally substituted with one or more halogen, - heteroaryl, - benzyl, which is optionally substituted with one or more halogen, alkyl or alkoxy, - amino, which is optionally substituted with one or two alkyl; ▪ heteroaryl group, which is optionally substituted with a (CH 2) k -heterocycloalkyl group, where k is 0, 1, 2 or 3; ▪ NH-R 3, wherein R 3 is hydrogen, alkyl, alkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aminoalkyl, aminoaryl or aminoheteroaryl, or R 3 is -CO-aryl, -CO-NH-aryl where the aryl is optionally substituted with one or more halogen; and n is 1, 2, 3 or 4.