A multipoint safety isolation system for a vehicle, comprising: an isolation device configured to: isolate a low voltage battery component from a high battery component, or isolate batteries of the HV battery component into a plurality of HV battery subpacks; an isolation trigger coupled to the isolation device and configured to: cause the isolation device to isolate the LV battery component from the HV battery component, or cause the isolation device to isolate the batteries of the HV battery component into the plurality of HV battery subpacks; at least one of an audio indicator or a visual indicator that indicates a location of the isolation trigger; a sensor configured to detect impact collision data or temperature data; and an electronic control unit coupled to the isolation device, the isolation trigger, the at least one of the audio indicator or the visual indicator, the electronic control unit being configured to: obtain the impact collision data or the temperature data, determine that the impact collision data exceeds a safety margin or that the temperature data exceeds a threshold temperature, activate the at least one of the audio indicator or the visual indicator to provide the location of the isolation trigger, and activate the isolation trigger to isolate the LV battery component from the HV battery component or isolate the batteries of the HV battery component into the plurality of HV battery subpacks. an isolation device configured to: isolate a low voltage battery component from a high battery component, or isolate batteries of the HV battery component into a plurality of HV battery subpacks; isolate a low voltage battery component from a high battery component, or isolate batteries of the HV battery component into a plurality of HV battery subpacks; an isolation trigger coupled to the isolation device and configured to: cause the isolation device to isolate the LV battery component from the HV battery component, or cause the isolation device to isolate the batteries of the HV battery component into the plurality of HV battery subpacks; cause the isolation device to isolate the LV battery component from the HV battery component, or cause the isolation device to isolate the batteries of the HV battery component into the plurality of HV battery subpacks; at least one of an audio indicator or a visual indicator that indicates a location of the isolation trigger; a sensor configured to detect impact collision data or temperature data; and an electronic control unit coupled to the isolation device, the isolation trigger, the at least one of the audio indicator or the visual indicator, the electronic control unit being configured to: obtain the impact collision data or the temperature data, determine that the impact collision data exceeds a safety margin or that the temperature data exceeds a threshold temperature, activate the at least one of the audio indicator or the visual indicator to provide the location of the isolation trigger, and activate the isolation trigger to isolate the LV battery component from the HV battery component or isolate the batteries of the HV battery component into the plurality of HV battery subpacks. obtain the impact collision data or the temperature data, determine that the impact collision data exceeds a safety margin or that the temperature data exceeds a threshold temperature, activate the at least one of the audio indicator or the visual indicator to provide the location of the isolation trigger, and activate the isolation trigger to isolate the LV battery component from the HV battery component or isolate the batteries of the HV battery component into the plurality of HV battery subpacks.