mhurhangee/ep-ind-claims huggingface dataset:
A process for producing an antibody or a fragment thereof comprising the steps of: (i) transforming a bacterial host cell with a single vector consisting of a dual cistronic expression system; (ii) culturing the transformed bacterial cells in suitable medium to express the antibody or a fragment thereof as inclusion bodies; (iii) performing solubilization of the said inclusion bodies; (iv) performing refolding of the antibody or the fragment thereof; wherein the dual cistronic expression system comprises: a) a first cistron comprising a T7 promoter operably linked with a polynucleotide sequence encoding a heavy chain of the antibody or the fragment thereof; b) a second cistron comprising an arabinose promoter operably linked with a polynucleotide sequence encoding a light chain of the antibody or the fragment thereof; wherein the first and second cistrons are positioned in the single vector and express the antibody or fragment thereof as inclusion bodies; and wherein heavy chain expression is induced by IPTG while light chain expression is induced by arabinose such that the heavy chain and light chain are expressed at equimolar levels of expression. (i) transforming a bacterial host cell with a single vector consisting of a dual cistronic expression system; (ii) culturing the transformed bacterial cells in suitable medium to express the antibody or a fragment thereof as inclusion bodies; (iii) performing solubilization of the said inclusion bodies; (iv) performing refolding of the antibody or the fragment thereof; wherein the dual cistronic expression system comprises: a) a first cistron comprising a T7 promoter operably linked with a polynucleotide sequence encoding a heavy chain of the antibody or the fragment thereof; b) a second cistron comprising an arabinose promoter operably linked with a polynucleotide sequence encoding a light chain of the antibody or the fragment thereof; wherein the first and second cistrons are positioned in the single vector and express the antibody or fragment thereof as inclusion bodies; and wherein heavy chain expression is induced by IPTG while light chain expression is induced by arabinose such that the heavy chain and light chain are expressed at equimolar levels of expression. a) a first cistron comprising a T7 promoter operably linked with a polynucleotide sequence encoding a heavy chain of the antibody or the fragment thereof; b) a second cistron comprising an arabinose promoter operably linked with a polynucleotide sequence encoding a light chain of the antibody or the fragment thereof;
Presentation case for a watch comprising at least one housing intended to receive a watch comprising, for the winding thereof, a winding crown, said presentation case comprising an automatic winding device for the watch arranged to be able to wind the watch using its winding crown when it is in place in its housing, characterised in that the automatic winding device for the watch comprises a winding carriage arranged to be translationally movable between a rest position, furthest away from the winding crown, and a winding position, closest to the winding crown, said winding carriage bearing a rotating shaft having a connecting member arranged to be able to cooperate with the winding crown when the winding carriage is in its winding position, the watch being in place in its housing, in order for it to be able to be wound.
A dialysis machine comprising a hydraulic circuit for the distribution of a solvent and of a bicarbonate solution produced with said solvent, and coupling means to couple a bag containing bicarbonate powder to said circuit; said coupling means comprising two ducts (40, 41), which can be connected to two respective passage elements (11, 12) of the bag; said circuit comprising: a main branch, which is flown through by the solvent according to a circulation direction; a solvent delivery branch, which connects the main branch to a first one of said ducts so as to feed the solvent to the bag; a solution return branch, which connects the second duct to the main branch, downstream of the connection to the solvent delivery branch relative to the circulation direction, so as to receive the solution obtained from the dissolution of the bicarbonate powder in the solvent inside the bag and to introduce the solution into the main branch; and a dripper, which is arranged in the solution return branch so as to prevent the gases generated with production of the solution to be introduced into the main branch; the dialysis machine being characterized in that each one of said ducts (40, 41) is provided with a respective filter (48, 49) so as to prevent the bicarbonate powder from entering said circuit.
Method of preventing tampering of a mobile device lock comprising: a client application executed in a mobile device monitoring the reception of presence messages transmitted by a user-detecting device in a vehicle, the user-detecting device comprising a motion sensor and a radio interface configured to wirelessly transmit presence messages when the motion sensor detects that the vehicle is moving; the client application repeatedly wirelessly transmitting notification messages to a server in a network, the notification messages signaling the server that the client application is being executed on the mobile device; the client application determining on the basis of a received presence message that the user of the mobile device is inside the vehicle; the client application monitoring the velocity of the vehicle and locking the mobile device for preventing the user to access the mobile device if the velocity of the vehicle is above a predetermined threshold; the client application monitoring user interaction with the mobile device and transmitting information associated with the user detecting device and/or the mobile device and/or the client application running on the mobile device and/or the location and/or speed of the vehicle in the notification messages to the server; and, the mobile device receiving a warning message from the server and notifying the user that tampering should be stopped, if the server determines on the basis of the information in the notification messages an indication that the user is tampering with the mobile device lock. a client application executed in a mobile device monitoring the reception of presence messages transmitted by a user-detecting device in a vehicle, the user-detecting device comprising a motion sensor and a radio interface configured to wirelessly transmit presence messages when the motion sensor detects that the vehicle is moving; the client application repeatedly wirelessly transmitting notification messages to a server in a network, the notification messages signaling the server that the client application is being executed on the mobile device; the client application determining on the basis of a received presence message that the user of the mobile device is inside the vehicle; the client application monitoring the velocity of the vehicle and locking the mobile device for preventing the user to access the mobile device if the velocity of the vehicle is above a predetermined threshold; the client application monitoring user interaction with the mobile device and transmitting information associated with the user detecting device and/or the mobile device and/or the client application running on the mobile device and/or the location and/or speed of the vehicle in the notification messages to the server; and, the mobile device receiving a warning message from the server and notifying the user that tampering should be stopped, if the server determines on the basis of the information in the notification messages an indication that the user is tampering with the mobile device lock.
A battery pack comprising: battery cells comprising first battery cells and second battery cells, each of the first and second battery cells comprising a first end portion and a second end portion that are opposite each other in a length direction thereof, adjacent first end portions being arranged in a stepped manner; and a case providing an accommodation space in which the battery cells and a cooling fluid to cool the battery cells are accommodated, the case comprising a first cover covering the first end portions of the battery cells, the first cover being arranged along a height difference between the first end portions of the first and second battery cells and defining a height difference space, corresponding to the height difference, on an outer side of the first cover. battery cells comprising first battery cells and second battery cells, each of the first and second battery cells comprising a first end portion and a second end portion that are opposite each other in a length direction thereof, adjacent first end portions being arranged in a stepped manner; and a case providing an accommodation space in which the battery cells and a cooling fluid to cool the battery cells are accommodated, the case comprising a first cover covering the first end portions of the battery cells, the first cover being arranged along a height difference between the first end portions of the first and second battery cells and defining a height difference space, corresponding to the height difference, on an outer side of the first cover.
A wireless terminal for use in a wireless cellular communication system comprising a radio access network, RAN, of a first type and also for use in a wireless cellular communication system comprising a radio access network, RAN, of a second type different from the first type, each RAN comprising at least one base station, the base stations of respective RANs being located in respective radio access cells that may be the same or different radio access cell, the wireless terminal being configured for registration with a RAN of the first type and a RAN of the second type at the same time and configured for wireless connection to a RAN of either the first type or the second type in a connected state, wherein: the wireless terminal is arranged, when registered with both a first RAN of the first type and a second RAN of the second type and when wirelessly connected to the first RAN in the connected state, to receive a mobility signal via the first RAN indicating a RAN of the second type, in response to receiving the mobility signal and in response to being so registered with the first RAN and second RAN, to transmit a routing area update for receipt by the second RAN, the routing area update indicating that the wireless terminal is to be connected to the second RAN in the connected state, characterized in that the wireless terminal is arranged, when the wireless terminal is in an idle mode signaling reduction, ISR, mode, to deactivate the idle mode signaling reduction mode before transmitting the routing area update. the wireless terminal is arranged, when registered with both a first RAN of the first type and a second RAN of the second type and when wirelessly connected to the first RAN in the connected state, to receive a mobility signal via the first RAN indicating a RAN of the second type, in response to receiving the mobility signal and in response to being so registered with the first RAN and second RAN, to transmit a routing area update for receipt by the second RAN, the routing area update indicating that the wireless terminal is to be connected to the second RAN in the connected state, characterized in that the wireless terminal is arranged, when the wireless terminal is in an idle mode signaling reduction, ISR, mode, to deactivate the idle mode signaling reduction mode before transmitting the routing area update. to transmit a routing area update for receipt by the second RAN, the routing area update indicating that the wireless terminal is to be connected to the second RAN in the connected state, characterized in that the wireless terminal is arranged, when the wireless terminal is in an idle mode signaling reduction, ISR, mode, to deactivate the idle mode signaling reduction mode before transmitting the routing area update.
A system comprising: a head-up display comprising: an overhead unit comprising a relay lens assembly; and a combiner; an illuminated reticle spatially coupled to the relay lens assembly, wherein a movement of the relay lens assembly results in a commensurate movement of the illuminated reticle, wherein the illuminated reticle comprises a light emitting diode and a diffuser, wherein the illuminated reticle is configured to emit a light pattern; an optical sensor spatially coupled to the combiner or optically coupled to a mirror spatially coupled to the combiner, wherein the optical sensor is configured to detect the light pattern emitted from the illuminated reticle; and a control module comprising one or more processors and a memory, wherein the control module is configured to: receive an input from the optical sensor; determine a position of the combiner relative to the relay lens assembly based on the received input; and generate an output based on a determined position of the combiner relative to the relay lens assembly; characterized in that the system is configured to: recognize the light pattern and determine an X, Z position of the reticle relative to the position of the sensor; and determine a distance from the sensor to the reticle based on a dispersion of the light pattern from the reticle. a head-up display comprising: an overhead unit comprising a relay lens assembly; and a combiner; an overhead unit comprising a relay lens assembly; and a combiner; an illuminated reticle spatially coupled to the relay lens assembly, wherein a movement of the relay lens assembly results in a commensurate movement of the illuminated reticle, wherein the illuminated reticle comprises a light emitting diode and a diffuser, wherein the illuminated reticle is configured to emit a light pattern; an optical sensor spatially coupled to the combiner or optically coupled to a mirror spatially coupled to the combiner, wherein the optical sensor is configured to detect the light pattern emitted from the illuminated reticle; and a control module comprising one or more processors and a memory, wherein the control module is configured to: receive an input from the optical sensor; determine a position of the combiner relative to the relay lens assembly based on the received input; and generate an output based on a determined position of the combiner relative to the relay lens assembly; receive an input from the optical sensor; determine a position of the combiner relative to the relay lens assembly based on the received input; and generate an output based on a determined position of the combiner relative to the relay lens assembly; characterized in that the system is configured to: recognize the light pattern and determine an X, Z position of the reticle relative to the position of the sensor; and determine a distance from the sensor to the reticle based on a dispersion of the light pattern from the reticle. recognize the light pattern and determine an X, Z position of the reticle relative to the position of the sensor; and determine a distance from the sensor to the reticle based on a dispersion of the light pattern from the reticle.
A scroll compressor comprising: a bearing housing including at least one radially extending arm having an axially extending bore; an orbiting scroll member including a first end plate and a first scroll wrap extending from the first end plate; a non-orbiting scroll member having a first acoustic impedance value, and including a second end plate, a second scroll wrap extending from the second end plate and meshingly engaged with the first scroll wrap, and a radially extending flanged portion comprising at least one axially extending aperture substantially aligned with the axially extending bore; at least one fastener disposed within the at least one axially extending aperture and the axially extending bore; and characterized by: a sound isolation member (55, 82, 84, 84a, 92a, 92b, 94) disposed between at least a portion of the fastener and at least a portion of the non-orbiting scroll member, wherein the sound isolation member comprises a composite material comprising a polymer and a plurality of particles, the composite material having a second acoustic impedance value greater than the first acoustic impedance value and a coefficient of thermal expansion of less than or equal to about 1.5 x 10 -3 1/°C for 0.25 mm growth. a bearing housing including at least one radially extending arm having an axially extending bore; an orbiting scroll member including a first end plate and a first scroll wrap extending from the first end plate; a non-orbiting scroll member having a first acoustic impedance value, and including a second end plate, a second scroll wrap extending from the second end plate and meshingly engaged with the first scroll wrap, and a radially extending flanged portion comprising at least one axially extending aperture substantially aligned with the axially extending bore; at least one fastener disposed within the at least one axially extending aperture and the axially extending bore; and characterized by: a sound isolation member (55, 82, 84, 84a, 92a, 92b, 94) disposed between at least a portion of the fastener and at least a portion of the non-orbiting scroll member, wherein the sound isolation member comprises a composite material comprising a polymer and a plurality of particles, the composite material having a second acoustic impedance value greater than the first acoustic impedance value and a coefficient of thermal expansion of less than or equal to about 1.5 x 10 -3 1/°C for 0.25 mm growth.
An in vitro method of generating immunosuppressive regulatory T cells from a sample, the method comprising: providing an initial sample containing a population of CD4+CD25 - T cells; and contacting the population with a T cell receptor /CD3 activator, a TCR co-stimulator activator, IL-2 and rapamycin, wherein the T cell receptor /CD3 activator is immobilized on a solid phase; and the TCR co- stimulator activator is immobilized on a solid phase; wherein the T cell receptor /CD3 activator is an antibody or a ligand for TCR/CD3, and wherein the TCR co-stimulator activator is a CD28 antibody, CD137 antibody, GITR antibody, B7-1/2 antibody, CD5 antibody, ICOS antibody, OX40 antibody, or CD40 antibody or a ligand for CD28, CD137, GITR, B7-1/2, CD5, ICOS, OX40 or CD40; generating a final sample comprising immunosuppressive CD4+CD25+FOXP3 - regulatory T cells. providing an initial sample containing a population of CD4+CD25 - T cells; and contacting the population with a T cell receptor /CD3 activator, a TCR co-stimulator activator, IL-2 and rapamycin, wherein the T cell receptor /CD3 activator is immobilized on a solid phase; and the TCR co- stimulator activator is immobilized on a solid phase; wherein the T cell receptor /CD3 activator is an antibody or a ligand for TCR/CD3, and wherein the TCR co-stimulator activator is a CD28 antibody, CD137 antibody, GITR antibody, B7-1/2 antibody, CD5 antibody, ICOS antibody, OX40 antibody, or CD40 antibody or a ligand for CD28, CD137, GITR, B7-1/2, CD5, ICOS, OX40 or CD40; generating a final sample comprising immunosuppressive CD4+CD25+FOXP3 - regulatory T cells.
Process for operating a fuel-operated vehicle heater, the vehicle heater comprising a burner area with a combustion chamber; a fuel pump for feeding fuel to the combustion chamber; and a combustion air blower for feeding combustion air to the combustion chamber, a pressure sensor being associated with the combustion air blower for detecting a feed back pressure downstream of the combustion air blower; further comprising an actuating unit for actuating the fuel pump such that the fuel pump is operated with a predefined value of a pump operating variable, and for actuating the combustion air blower such that the combustion air blower is operated with a predefined value of a blower operating variable, in which process associated with feed operating states and with a reference fuel defined by the pump operating variable and the blower operating variable, information on a feed back pressure to be expected in each case is provided, wherein the process further comprises the following steps: a) detection of the feed back pressure in case of a feed operating state set during the combustion operation, b) comparison of the detected feed back pressure (P e) with the feed back pressure (P E) to be expected for the set feed operating state, c) if the detected feed back pressure (P e) deviates from the feed back pressure (P E) to be expected, changing the pump operating variable such that the feed back pressure changes in the direction toward the expected feed pressure or/and essentially corresponds to the expected feed back pressure (P E). a) detection of the feed back pressure in case of a feed operating state set during the combustion operation, b) comparison of the detected feed back pressure (P e) with the feed back pressure (P E) to be expected for the set feed operating state, c) if the detected feed back pressure (P e) deviates from the feed back pressure (P E) to be expected, changing the pump operating variable such that the feed back pressure changes in the direction toward the expected feed pressure or/and essentially corresponds to the expected feed back pressure (P E).
A lamination device comprising: a power source unit; and a pattern roller including a rotation roller and a pattern cover, wherein the pattern roller is configured to embody a pattern on an electrode assembly, wherein the rotation roller is configured to emit heat supplied from the power source unit and to press a surface of the electrode assembly together with the heat, and the pattern cover comprises a pattern film for embodying the pattern and a deformation member, wherein the pattern film comprises an outer film and an inner film disposed on an inner surface of the outer film and having a width less than that of the outer film, the outer film has strength greater than that of the inner film, and the deformation member is made of a shape-memory alloy material and disposed in each of one or more opening grooves formed between a side portion of the inner film and the inner surface of the outer film in a direction perpendicular to an axis of the rotation roller. a power source unit; and a pattern roller including a rotation roller and a pattern cover, wherein the pattern roller is configured to embody a pattern on an electrode assembly, wherein the rotation roller is configured to emit heat supplied from the power source unit and to press a surface of the electrode assembly together with the heat, and the pattern cover comprises a pattern film for embodying the pattern and a deformation member,
An applicator for applying thermotherapy to a part of the human or animal body comprising: a flexible enclosure in which thermal energy transfer fluid can circulate; a connector for connecting the applicator to a control system; an interface layer attached to an outer surface of the flexible enclosure for providing a thermally conductive interface between the flexible enclosure and a part of a human or animal body; and and electrically conductive supporting layer for supporting the interface layer relative to the flexible enclosure, coupled to the control system to receive an electrical signal, characterised in that the interface layer is a colloidal fluid including electrically conductive particles in suspension and held within a membranous enclosure supported by the electrically conductive supporting layer, and the colloid is activatable in response to an electric current to become more viscous and gel-like. a flexible enclosure in which thermal energy transfer fluid can circulate; a connector for connecting the applicator to a control system; an interface layer attached to an outer surface of the flexible enclosure for providing a thermally conductive interface between the flexible enclosure and a part of a human or animal body; and