mhurhangee/ep-ind-claims huggingface dataset:
Vibratory screener, comprising a screen carrier frame having an inner circumference and an outer circumference, a screen for separation of solid particles extending horizontally within the screen carrier frame and being vertically supported by the screen carrier frame, and at least two internal annular disks (14.1, 14.2, 14.3) each having an inner rim (15.1, 15.2, 15.3) and an outer rim (16.1, 16.2, 16.3), wherein each of said at least two internal annular disks (14.1, 14.2, 14.3) is attached to the inner circumference of the screen carrier frame by its outer rim (16.1, 16.2, 16.3), and wherein said at least two internal annular disks (14.1, 14.2, 14.3) are spaced apart from each other in parallel planes, characterized by one or more vibration motors arranged on the outer circumference of the screen carrier frame and configured to generate a component of vibration in a direction (z) perpendicular to the screen, and an inner sleeve arranged within the screen carrier frame and attached to the inner rims (15.2, 15.3) of two (14.2, 14.3) of said at least two internal annular disks, wherein the upper internal annular disk (14.2) of said two internal annular disks and the inner sleeve provide an unbroken surface whereas the lower internal annular disk (14.3) of said two internal annular disks is provided with openings towards the outside environment. a screen carrier frame having an inner circumference and an outer circumference, a screen for separation of solid particles extending horizontally within the screen carrier frame and being vertically supported by the screen carrier frame, and at least two internal annular disks (14.1, 14.2, 14.3) each having an inner rim (15.1, 15.2, 15.3) and an outer rim (16.1, 16.2, 16.3), wherein each of said at least two internal annular disks (14.1, 14.2, 14.3) is attached to the inner circumference of the screen carrier frame by its outer rim (16.1, 16.2, 16.3), and wherein said at least two internal annular disks (14.1, 14.2, 14.3) are spaced apart from each other in parallel planes, characterized by one or more vibration motors arranged on the outer circumference of the screen carrier frame and configured to generate a component of vibration in a direction (z) perpendicular to the screen, and an inner sleeve arranged within the screen carrier frame and attached to the inner rims (15.2, 15.3) of two (14.2, 14.3) of said at least two internal annular disks, wherein the upper internal annular disk (14.2) of said two internal annular disks and the inner sleeve provide an unbroken surface whereas the lower internal annular disk (14.3) of said two internal annular disks is provided with openings towards the outside environment.
A composition comprising an mRNA encoding a frataxin protein for use in a method of treating Friedreich's ataxia (FRDA) comprising administering said composition to a subject in need of treatment; wherein the composition is administered to the subject via intrathecal delivery; wherein the mRNA comprises a polynucleotide sequence at least 90% identical to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4; and the mRNA is codon optimized; wherein the mRNA comprises a polynucleotide sequence wherein: i. the percentage of guanine nucleotides is at least 28%, the percentage of cytosine nucleotides is at least 30%, the combined percentage of guanine and cytosine nucleotides is at least 59%, and/or the percentage of adenine nucleotides is no more than 22.5%; and/or ii. the percent change in the number of guanine nucleotides relative to a native human FXN mRNA sequence is at least 9%, the percent change in the number of cytosine nucleotides relative to a native human FXN mRNA sequence is at least 7%, the percent change in the combined number of guanine and cytosine nucleotides relative to a native human FXN mRNA is at least 9%, and/or the percent change in the number of adenine nucleotides relative to a native human FXN mRNA sequence is at least -7%. i. the percentage of guanine nucleotides is at least 28%, the percentage of cytosine nucleotides is at least 30%, the combined percentage of guanine and cytosine nucleotides is at least 59%, and/or the percentage of adenine nucleotides is no more than 22.5%; and/or ii. the percent change in the number of guanine nucleotides relative to a native human FXN mRNA sequence is at least 9%, the percent change in the number of cytosine nucleotides relative to a native human FXN mRNA sequence is at least 7%, the percent change in the combined number of guanine and cytosine nucleotides relative to a native human FXN mRNA is at least 9%, and/or the percent change in the number of adenine nucleotides relative to a native human FXN mRNA sequence is at least -7%.
A light fixture control system, the light fixture control system comprising a control box and a plurality of wireless switches, each wireless switch is wirelessly and communicatively connected to the control box; an output end of the control box is connectable to a plurality of LED lamps, the control box comprises a main controller, a code matching control circuit, a first wireless communication circuit and a multiple-independent-output control interface circuit, the main controller is connected to the code matching control circuit and the first wireless communication circuit, respectively and an output end of the main controller is connected to the multiple-independent-output control interface circuit; output ends of the multiple-independent-output control interface circuit are connectable to the plurality of LED lamps in a one-to-one correspondence; wherein, the first wireless communication circuit is configured to receive a wireless switch signal output by the plurality of wireless switches; the code matching control circuit is configured to output a corresponding code matching signal to the main controller according to an operation instruction of a user; the main controller is configured to output a corresponding LED switch control signal to the multiple-independent-output control interface circuit according to the code matching signal and the wireless switch signal, and is configured to drive one or more corresponding LED lamps of the plurality of LED lamps to operate; and wherein, based on the code matching signal and the wireless switch signal, a corresponding control relationship is established between the plurality of wireless switches and the plurality of LED lamps such that each of the plurality of wireless switches is able to control one LED lamp or more LED lamps of the plurality of LED lamps. the first wireless communication circuit is configured to receive a wireless switch signal output by the plurality of wireless switches; the code matching control circuit is configured to output a corresponding code matching signal to the main controller according to an operation instruction of a user; the main controller is configured to output a corresponding LED switch control signal to the multiple-independent-output control interface circuit according to the code matching signal and the wireless switch signal, and is configured to drive one or more corresponding LED lamps of the plurality of LED lamps to operate; and wherein, based on the code matching signal and the wireless switch signal, a corresponding control relationship is established between the plurality of wireless switches and the plurality of LED lamps such that each of the plurality of wireless switches is able to control one LED lamp or more LED lamps of the plurality of LED lamps.
Continuous method for preparing neopentyl glycol by addition of isobutyraldehyde and formaldehyde in the presence of a tertiary alkylamine as catalyst to give hydroxypivalaldehyde with subsequent hydrogenation in the gas phase at a temperature of 125 to 180°C, characterised in that the hydrogenation is carried out in the presence of a copper chromite catalyst comprising the activators barium and manganese and at a superatmospheric pressure of 30 to 120 kPa.
A sending apparatus, comprising a processing unit (1901, 2001) and a sending unit, wherein the processing unit (1901, 2001) is configured to determine a first low-density parity-check LDPC matrix based on a quantity n 1 of first transmission bits; the processing unit (1901, 2001) is further configured to encode information bits based on the first LDPC matrix, to obtain the first transmission bits; and the sending unit is configured to send the first transmission bits; wherein the quantity n 1 of the first transmission bits has a correspondence with a coding rate of the first LDPC matrix, characterised in that: if n 1 is less than No, the coding rate of the first LDPC matrix is 5/6; if n 1 is greater than or equal to N0 and less than N1, the coding rate of the first LDPC matrix is 5/6; if n 1 is greater than or equal to N1 and less than N2, the coding rate of the first LDPC matrix is 3/4; if n 1 is greater than or equal to N2 and less than N3, the coding rate of the first LDPC matrix is 2/3; if n 1 is greater than or equal to N3 and less than or equal to N4, the coding rate of the first LDPC matrix is 1/2; or if n 1 is greater than N4, the coding rate of the first LDPC matrix is 1/2; wherein N0 is 324; N1 is 468; N2 is 648; N3 is 972; and N4 is 1932. the processing unit (1901, 2001) is configured to determine a first low-density parity-check LDPC matrix based on a quantity n 1 of first transmission bits; the processing unit (1901, 2001) is further configured to encode information bits based on the first LDPC matrix, to obtain the first transmission bits; and the sending unit is configured to send the first transmission bits; wherein the quantity n 1 of the first transmission bits has a correspondence with a coding rate of the first LDPC matrix, characterised in that: if n 1 is less than No, the coding rate of the first LDPC matrix is 5/6; if n 1 is greater than or equal to N0 and less than N1, the coding rate of the first LDPC matrix is 5/6; if n 1 is greater than or equal to N1 and less than N2, the coding rate of the first LDPC matrix is 3/4; if n 1 is greater than or equal to N2 and less than N3, the coding rate of the first LDPC matrix is 2/3; if n 1 is greater than or equal to N3 and less than or equal to N4, the coding rate of the first LDPC matrix is 1/2; or if n 1 is greater than N4, the coding rate of the first LDPC matrix is 1/2; wherein N0 is 324; N1 is 468; N2 is 648; N3 is 972; and N4 is 1932.
Pneumatic vehicle tyre for utility vehicles having a belt and having a tread profile which extends in an axial direction A of the pneumatic vehicle tyre between two tyre shoulders, in which tyre shoulders there is formed in each case one shoulder profile band which is formed so as to extend over the circumference of the pneumatic vehicle tyre and which is delimited, in the axial direction A toward the equatorial plane Ä of the tyre, by a channel extending over the circumference of the pneumatic vehicle tyre and, on its side pointing away from the equatorial plane Ä, in each case by a surface of the tyre side wall, which surface forms that flank of the shoulder profile band which points away from the equatorial plane Ä, wherein, in the section planes that encompass the tyre axis, the tread profile is delimited by a surface which forms the road contact surface and which, between the shoulder profile bands, forms a surface contour line K which is curved toward the tyre, wherein the surface which forms the road contact surface is, in at least one shoulder profile band, in an axial first extent section of the width a adjacent to the circumferential channel, formed as the elongation of the curved surface contour line K into the shoulder profile band and, in a second extent section of the width c adjoining the first extent section and extending as far as the surface of the tyre side wall, declines continuously in terms of its radial position of the tyre outwardly along the axial extent, wherein the surface which forms the road contact surface is, in the second extent section, formed with a first subsection, which extends as far as a point P, and from a second subsection, which extends from the point P to the surface of the tyre side wall, wherein the surface which forms the road contact surface is formed with a concavely curved contour profile in the first subsection and with a convexly curved contour profile in the second subsection, with a turning point of the contour profile at the point P, wherein the point P is arranged outside the belt in the axial direction A, characterized in that, in the section planes that encompass the tyre axis, the concavely curved contour profile is a contour profile curved with a curvature radius R a about a curvature central point M a, wherein the curvature central point M a is arranged outside the contour line on that side of the contour line which points away from the tyre, and in that the first subsection with concavely curved contour profile is formed so as to extend in the axial direction A of the tyre from an axial position within the belt extent to the point P outside the belt.
A toilet lid (102, 202) capable of being connected to a toilet seat (104, 204), wherein the toilet lid comprises: a core structural layer having a shape and size associated with the toilet lid, wherein the core structural layer is formed of medium density fiberboard or molded wood; a first decorative graphic layer disposed on a first surface of the core structural layer, wherein the first decorative graphic layer comprises a paper comprising at least one of image, graphic, text, picture or a plain color; a first exterior layer disposed on the top surface of the toilet lid on the exterior surface of the first decorative graphic layer; wherein the first exterior layer comprises polymethyl-methacrylate (PMMA); and a second exterior layer disposed on the bottom surface of the toilet lid and opposite to the first exterior layer; wherein the second exterior layer is an exterior finish layer that is not clear. a core structural layer having a shape and size associated with the toilet lid, wherein the core structural layer is formed of medium density fiberboard or molded wood; a first decorative graphic layer disposed on a first surface of the core structural layer, wherein the first decorative graphic layer comprises a paper comprising at least one of image, graphic, text, picture or a plain color; a first exterior layer disposed on the top surface of the toilet lid on the exterior surface of the first decorative graphic layer; wherein the first exterior layer comprises polymethyl-methacrylate (PMMA); and a second exterior layer disposed on the bottom surface of the toilet lid and opposite to the first exterior layer; wherein the second exterior layer is an exterior finish layer that is not clear.
A device for the recording by sensors of at least one human vital parameter, with a carrier, which is suitably shaped and dimensioned to be placed in a removable manner at least partially in the human external auditory canal and on which at least one sensor for recording a vital parameter is applied wherein the carrier is in the form of a hollow cylinder, outwardly delimits a continuously open hollow channel radially to a cylinder axis assigned to the hollow cylinder, and comprises a hollow cylinder outer wall area which in the state of placement of the carrier at least partially in the human auditory canal is configured to come into contact therewith, characterised in that the carrier is a surface substrate which through winding around a winding axis can be transformed in the form of the hollow cylinder, and in that the surface substrate has a material-inherent shape-retaining stiffness so that the surface substrate transformed by winding into the form of a hollow cylinder has two surface substrate regions lying opposite each other which due to winding and without external mechanical force, loosely overlap each other.
An optical signal processing apparatus comprising: an input unit to which signal light is input; a wave coupling unit for coupling the signal light from the input unit and pump light having a wavelength different from that of the signal light; a first nonlinear optical medium for transmitting light coupled by the wave coupling unit, the light being the signal light and the pump light; a dispersion medium for transmitting the light that has been transmitted through the first nonlinear optical medium, the dispersion medium having a length that causes relative timing of the signal light and the pump light traveling through the dispersion medium to shift; and a second nonlinear optical medium that transmits the light that has been transmitted through the dispersion medium, wherein the dispersion medium and the second nonlinear optical medium are disposed in N combination(s) downstream from the first nonlinear optical medium, where N is a positive integer, and the dispersion medium has a length that causes an extent of a shift of the timing to be approximately 1/(N+1) of a pulse interval of the pump light. an input unit to which signal light is input; a wave coupling unit for coupling the signal light from the input unit and pump light having a wavelength different from that of the signal light; a first nonlinear optical medium for transmitting light coupled by the wave coupling unit, the light being the signal light and the pump light; a dispersion medium for transmitting the light that has been transmitted through the first nonlinear optical medium, the dispersion medium having a length that causes relative timing of the signal light and the pump light traveling through the dispersion medium to shift; and a second nonlinear optical medium that transmits the light that has been transmitted through the dispersion medium, wherein the dispersion medium and the second nonlinear optical medium are disposed in N combination(s) downstream from the first nonlinear optical medium, where N is a positive integer, and the dispersion medium has a length that causes an extent of a shift of the timing to be approximately 1/(N+1) of a pulse interval of the pump light.
A weaning pacifier, of the type comprising: - a mouthpiece intended to be suckled by a child; - a handle; - at least one base flange having a base thickness and on one side of which the mouthpiece extends so as to have a suction length L, and on the other side of which the handle extends; - a system for reducing the length L, characterised in that the reduction system comprises at least one first adjustment flange having a passage for the mouthpiece so as to surround the mouthpiece and means for coupling the first adjustment flange to the base flange so as to present the first adjustment flange on the side of the mouthpiece with respect to the base flange, the first adjustment flange having a first adjustment thickness at least equal to the base thickness, and in that it comprises at least one second adjustment flange having a passage for the mouthpiece so as to surround the mouthpiece and means for fastening the second adjustment flange to the first adjustment flange so as to present the second adjustment flange on the side of the mouthpiece with respect to the first adjustment flange, the second adjustment flange having a second adjustment thickness at least equal to the base thickness. - a mouthpiece intended to be suckled by a child; - a handle; - at least one base flange having a base thickness and on one side of which the mouthpiece extends so as to have a suction length L, and on the other side of which the handle extends; - a system for reducing the length L,
A rotational atherectomy device for removing a stenotic tissue from a vessel of a patient, the device comprising a rotatable, flexible, hollow drive shaft and, an abrasive element (1,101) mounted to a distal end portion of the drive shaft, characterised in that the drive shaft has a fluid impermeable wall defining a fluid impermeable lumen of the drive shaft, the abrasive element (1,101) being mounted proximal to and spaced away from a distal support element formed at a distal end of the drive shaft, the distal support element being inflatable by pressurized fluid which flows in an antegrade direction through said lumen of the drive shaft and is at least partially re-directed into the distal fluid inflatable support element, wherein the distal fluid inflatable support element has an outer wall comprising an outflow opening located such that said outflow opening faces an inner surface of a treated vessel during rotation of the drive shaft so that a flow of fluid through said outflow opening forms a layer of fluid between the outer wall of the rotating fluid inflated distal support element and a wall of the treated vessel to form a fluid bearing between the outer wall of the rotating fluid inflated distal support element and the wall of the treated vessel, the drive shaft being comprised of at least one fluid impermeable membrane and at least two torque transmitting coils (4,44), one of said coils extending distally beyond the distal end of the other coil and conveying torque to the abrasive element mounted to the drive shaft distal to and spaced away from a portion of the drive shaft formed from the fluid impermeable membrane and said torque transmitting coils (4,44).
A method of imaging an object that is at least partially obscured by an obscuration, the method comprising: generating frequency-entangled photons including photons having first and second frequencies wherein the first frequency is selected such that the photons with the first frequency can pass through the obscuration; sending the photons having the first frequency down a first path toward the object and sending the photons having the second frequency down a second path, the second path separate from the first path; illuminating the object with the photons having the first frequency; and using photons having the first frequency scattered by the object and the photons having the second frequency to form an image by counting coincidences in time of arrival, wherein the photons scattered by the object are correlated with the photons having the second frequency. generating frequency-entangled photons including photons having first and second frequencies wherein the first frequency is selected such that the photons with the first frequency can pass through the obscuration; sending the photons having the first frequency down a first path toward the object and sending the photons having the second frequency down a second path, the second path separate from the first path; illuminating the object with the photons having the first frequency; and using photons having the first frequency scattered by the object and the photons having the second frequency to form an image by counting coincidences in time of arrival, wherein the photons scattered by the object are correlated with the photons having the second frequency.