A compound of Formula: wherein R 1 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (alkoxycarbonyl)alkyl, alkoxycarbonyl, (NR 6 R 7)carbonyl, Ar 1, or (Ar 1)alkyl; Ar 1 is cycloalkyl, aryl, heteroaryl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, heterocyclyl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, or spiroheterocyclyl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, each substituted with 1-5 R 5; R 2 is hydrogen, alkyl, or haloalkyl; R 3 is phenyl or pyridinyl substituted with 1 R 3a and 1-2 R 3b; R 3a is halo, haloalkyl, alkoxy, or haloalkoxy; R 3b is hydrogen, halo, or haloalkyl; R 4 is phenyl or pyridinyl substituted with 1-2 R 4a; R 4a is halo, alkoxy, or haloalkoxy; R 5 is hydrogen, hydroxyl, cyano, halo, alkyl, haloalkyl, amino, haloalkylamino, alkoxyalkyl, hydroxyalkyl, alkoxy, haloalkoxy, carboxamide, alkoxycarbonyl, alkylsulfonylamino, or hydroxyalkylcarbonyl; R 5a is hydrogen, alkyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, hydroalkylcarbonyl, carboxamide, alkylaminocarbonyl, aminocarbonylalkylcarbonyl, alkylsulfonyl, or alkoxycarbonyl; R 6 and R 7 are independently hydrogen, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, aryl, heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S, heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S, arylalkyl, or heteroarylalkyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S; wherein said cycloalkyl, aryl, heteroaryl, or heterocyclyl is substituted with 1-5 R 8; or R 6 and R 7, together with the nitrogen to which they are attached, form a heterocyclyl or heteroaryl comprising carbon atoms and 0-3 additional heteroatoms selected from N, NR 8a, O, S, wherein said heteroaryl or heterocyclyl is substituted with 1-5 R 8; R 8 is hydrogen, halo, hydroxy, hydroxyalkyl, alkyl, alkoxy, or oxo; R 8a is hydrogen, hydroxyalkyl, or alkyl; or a pharmaceutically acceptable salt thereof. R 1 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (alkoxycarbonyl)alkyl, alkoxycarbonyl, (NR 6 R 7)carbonyl, Ar 1, or (Ar 1)alkyl; Ar 1 is cycloalkyl, aryl, heteroaryl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, heterocyclyl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, or spiroheterocyclyl comprising carbon atoms and 1-5 heteroatoms selected from N, NR 5a, O, and S, each substituted with 1-5 R 5; R 2 is hydrogen, alkyl, or haloalkyl; R 3 is phenyl or pyridinyl substituted with 1 R 3a and 1-2 R 3b; R 3a is halo, haloalkyl, alkoxy, or haloalkoxy; R 3b is hydrogen, halo, or haloalkyl; R 4 is phenyl or pyridinyl substituted with 1-2 R 4a; R 4a is halo, alkoxy, or haloalkoxy; R 5 is hydrogen, hydroxyl, cyano, halo, alkyl, haloalkyl, amino, haloalkylamino, alkoxyalkyl, hydroxyalkyl, alkoxy, haloalkoxy, carboxamide, alkoxycarbonyl, alkylsulfonylamino, or hydroxyalkylcarbonyl; R 5a is hydrogen, alkyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, hydroalkylcarbonyl, carboxamide, alkylaminocarbonyl, aminocarbonylalkylcarbonyl, alkylsulfonyl, or alkoxycarbonyl; R 6 and R 7 are independently hydrogen, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, aryl, heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S, heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S, arylalkyl, or heteroarylalkyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8a, O, and S; wherein said cycloalkyl, aryl, heteroaryl, or heterocyclyl is substituted with 1-5 R 8; or R 6 and R 7, together with the nitrogen to which they are attached, form a heterocyclyl or heteroaryl comprising carbon atoms and 0-3 additional heteroatoms selected from N, NR 8a, O, S, wherein said heteroaryl or heterocyclyl is substituted with 1-5 R 8; R 8 is hydrogen, halo, hydroxy, hydroxyalkyl, alkyl, alkoxy, or oxo; R 8a is hydrogen, hydroxyalkyl, or alkyl; or a pharmaceutically acceptable salt thereof.