A method for making a Nanolipidic Particle assembly population, comprising the steps of: (a) providing a monophasic precursor solution, said monophasic precursor solution made by; solubilizing an amphipathic material comprising phospholipids in a first quantity of non-aqueous solvent; adding a quantity of water to form a turbid suspension; and adding a second quantity of nonaqueous solvent until the turbid suspension is monophasic and has optical clarity at room temperature; (b) admixing a passenger molecule selected from the group consisting of lipophilic and amphipathic passenger molecules with said monophasic precursor solution to form a loaded vehicle population; (c) diluting said loaded vehicle population with one or more aliquots of non-aqueous solvent to form an NLP loaded particle population; (i) said non-aqueous solvent is added in a sequential manner to the precursor solution after addition of a passenger molecule, (ii) said loaded vehicle population is combined with said nonaqueous solvent at a ratio ranging from about 1 part loaded vehicle population to 20 parts non-aqueous solvent, to a ratio of 1 part loaded vehicle population to 0.3 parts non-aqueous solvent, (iii) wherein said diluting of said loaded vehicle population forms a NLP loaded particle population having nanolipidic particles (NLPs) sized from 1 nm to 20 nm, said sizes determined by laser light scattering at ambient room temperature, and said NLP size decreasing as said non-aqueous solvent concentration increases, and (d) admixing an aliquot of said loaded NLP population with an aqueous solvent to form a NLP assembly population having a mean particle diameter of 20 to 200 nm. (a) providing a monophasic precursor solution, said monophasic precursor solution made by; solubilizing an amphipathic material comprising phospholipids in a first quantity of non-aqueous solvent; adding a quantity of water to form a turbid suspension; and adding a second quantity of nonaqueous solvent until the turbid suspension is monophasic and has optical clarity at room temperature; solubilizing an amphipathic material comprising phospholipids in a first quantity of non-aqueous solvent; adding a quantity of water to form a turbid suspension; and adding a second quantity of nonaqueous solvent until the turbid suspension is monophasic and has optical clarity at room temperature; (b) admixing a passenger molecule selected from the group consisting of lipophilic and amphipathic passenger molecules with said monophasic precursor solution to form a loaded vehicle population; (c) diluting said loaded vehicle population with one or more aliquots of non-aqueous solvent to form an NLP loaded particle population; (i) said non-aqueous solvent is added in a sequential manner to the precursor solution after addition of a passenger molecule, (ii) said loaded vehicle population is combined with said nonaqueous solvent at a ratio ranging from about 1 part loaded vehicle population to 20 parts non-aqueous solvent, to a ratio of 1 part loaded vehicle population to 0.3 parts non-aqueous solvent, (iii) wherein said diluting of said loaded vehicle population forms a NLP loaded particle population having nanolipidic particles (NLPs) sized from 1 nm to 20 nm, said sizes determined by laser light scattering at ambient room temperature, and said NLP size decreasing as said non-aqueous solvent concentration increases, and (i) said non-aqueous solvent is added in a sequential manner to the precursor solution after addition of a passenger molecule, (ii) said loaded vehicle population is combined with said nonaqueous solvent at a ratio ranging from about 1 part loaded vehicle population to 20 parts non-aqueous solvent, to a ratio of 1 part loaded vehicle population to 0.3 parts non-aqueous solvent, (iii) wherein said diluting of said loaded vehicle population forms a NLP loaded particle population having nanolipidic particles (NLPs) sized from 1 nm to 20 nm, said sizes determined by laser light scattering at ambient room temperature, and said NLP size decreasing as said non-aqueous solvent concentration increases, (d) admixing an aliquot of said loaded NLP population with an aqueous solvent to form a NLP assembly population having a mean particle diameter of 20 to 200 nm.