mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical immuno-oncology combination for use in a method of treatment of cancer in an individual, said combination comprising: (i) a checkpoint inhibitor that is an anti-PD-1 or PD-L1 inhibitory antibody, and (ii) an expression vector encoding an antigen specific TAA/ecdCD40L vaccine component, wherein TAA/ecdCD40L is a fusion protein of a mucin-1 antigen ("TAA", MUC1) and the extracellular domain of a CD40 ligand ("ecdCD40L"), with CD40 ligand also being known as CD154 or TNF5, excluding at least the transmembrane domain that inhibits secretion, wherein said checkpoint inhibitor and said vaccine component are both to be administered to an individual including additional boosts of the same; the administration generates an immune response against a cancerous tumor antigen in said individual by effecting a reduction of total population of CD11b positive cells in the cancerous tumor and increasing the magnitude of the antitumor immune response in said individual; and the checkpoint inhibitor and the vaccine component are administered as a combination at effective amounts over a common time period to produce through their biological interaction an enhanced synergistic immune response relative to an immune response by the checkpoint inhibitor antibody component administered as monotherapy. (i) a checkpoint inhibitor that is an anti-PD-1 or PD-L1 inhibitory antibody, and (ii) an expression vector encoding an antigen specific TAA/ecdCD40L vaccine component, wherein TAA/ecdCD40L is a fusion protein of a mucin-1 antigen ("TAA", MUC1) and the extracellular domain of a CD40 ligand ("ecdCD40L"), with CD40 ligand also being known as CD154 or TNF5, excluding at least the transmembrane domain that inhibits secretion, wherein said checkpoint inhibitor and said vaccine component are both to be administered to an individual including additional boosts of the same; the administration generates an immune response against a cancerous tumor antigen in said individual by effecting a reduction of total population of CD11b positive cells in the cancerous tumor and increasing the magnitude of the antitumor immune response in said individual; and the checkpoint inhibitor and the vaccine component are administered as a combination at effective amounts over a common time period to produce through their biological interaction an enhanced synergistic immune response relative to an immune response by the checkpoint inhibitor antibody component administered as monotherapy.
A porcelain laminate characterised in that it comprises two sheets: - a sheet of porcelain material with a thickness between 2 to 7 mm glued to - a sheet serving as a base or support, where the support sheet is formed by a laminate that has a core of any of the components of the group formed by medium density fibreboard, chipboard, high density foam, polyethylene, polypropylene, ABS, PVC foam, methacrylate, high pressure laminate and phenolic plywood, and which is laminated on both sides by two metallic sheets of aluminium that have a thickness of 0.4 to 3 mm, the two sheets of aluminium not having to have the same thickness. - a sheet of porcelain material with a thickness between 2 to 7 mm glued to - a sheet serving as a base or support,
Use of a complex for catalysis of a hydroformylation reaction comprising: a) Pt; b) a ligand corresponding to formula: where R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are selected from: -H, -(C 1 -C 12)-alkyl, -(C 6 -C 20)-aryl; and, if R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are -(C 6 -C 20)-aryl, the aryl ring may have substituents selected from: -(C 1 -C 12)-alkyl, -O-(C 1 -C 12)-alkyl; c) an iodine ligand. a) Pt; b) a ligand corresponding to formula: where R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are selected from: -H, -(C 1 -C 12)-alkyl, -(C 6 -C 20)-aryl; and, if R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are -(C 6 -C 20)-aryl, the aryl ring may have substituents selected from: -(C 1 -C 12)-alkyl, -O-(C 1 -C 12)-alkyl; c) an iodine ligand.
A method in a first base station, the method comprising: detecting latency information of data being transmitted on at least one link between a first base station and at least one second base station; forming a latency histogram comprising at least one array where each array entry represents one latency range of the data; and modifying a system behavior relating to at least one of the first base station or the at least one second base station based on the at least one array included in the latency histogram. detecting latency information of data being transmitted on at least one link between a first base station and at least one second base station; forming a latency histogram comprising at least one array where each array entry represents one latency range of the data; and modifying a system behavior relating to at least one of the first base station or the at least one second base station based on the at least one array included in the latency histogram.
An ablation device, comprising an ablation applicator for applying ablation energy to an ablation region, the ablation applicator having a first applicator end portion, a second applicator end portion, and an elongate portion extending between the first and second applicator end portions, a first catheter having a first distal end portion and a first proximate end portion, the first distal end portion being coupled to the first applicator end portion, and a second catheter having a second distal end portion and a second proximate end portion, the second distal end portion being coupled to the second applicator end portion to supply an ablation medium to the ablation applicator, wherein the ablation applicator is adapted to form an applicator shape having an applicator size in a plane perpendicular to a longitudinal axis of the first catheter, and wherein the coupling between the first distal end portion and the first applicator end portion is adapted to transfer a rotational force applied to the first proximate end portion to the ablation applicator and thereby cause the applicator size to change, the ablation device further comprising a handle housing the first proximate end portion and the second proximate end portion, the handle comprising a rotational member for applying the rotational force to the first proximate portion. an ablation applicator for applying ablation energy to an ablation region, the ablation applicator having a first applicator end portion, a second applicator end portion, and an elongate portion extending between the first and second applicator end portions, a first catheter having a first distal end portion and a first proximate end portion, the first distal end portion being coupled to the first applicator end portion, and a second catheter having a second distal end portion and a second proximate end portion, the second distal end portion being coupled to the second applicator end portion to supply an ablation medium to the ablation applicator, wherein the ablation applicator is adapted to form an applicator shape having an applicator size in a plane perpendicular to a longitudinal axis of the first catheter, and wherein the coupling between the first distal end portion and the first applicator end portion is adapted to transfer a rotational force applied to the first proximate end portion to the ablation applicator and thereby cause the applicator size to change, the ablation device further comprising a handle housing the first proximate end portion and the second proximate end portion, the handle comprising a rotational member for applying the rotational force to the first proximate portion.
Apparatus for car windshield removal, wherein the apparatus has the structure of an over 360 degrees rotatably working swivel head on the perpendicular axle of a suction plate, which is applied on the inner- or outer side of said windshield, wherein said swivel head has a wind up medium for hauling in a cutting thread or wire, which is cutting through the adhesive bead between the coach frame and the windshield edge, characterized in that said working swivel head of the apparatus is executed eccentrically rotating around said perpendicular axle of said suction plate, wherein in said working swivel head an electromotor with a driving axle is installed with at the outer end a winch up wheel for fixing a sawing and cutting thread (31,25) and said winch up wheel is directed to the windshield (5,15), wherein said winch up wheel has an extra outer bigger flange with three eccentric applied bore holes ( 11,12,13), wherein in one bore hole with a ring and over 360 degrees rotatably, an elongated strip is mounted for fixing one end of the sawing and cutting thread (31,25), for executing a sawing and cutting movement of said thread through said adhesive bead (4, 14) and the other end of said sawing and cutting thread is fixed in the remaining bore holes ( 11,12) of said outer flange or at a held hand grip.
A tower for a wind turbine generator, the tower comprising a system comprising a platform mounted to said tower, a housing arranged on the platform, and a crane arranged on the platform and arranged to lift equipment after removal from the housing and to lower the equipment on to an external surface, wherein the system further comprises an apparatus for removing the equipment from a housing arranged on the platform of the wind turbine generator, the apparatus comprising: a winch for withdrawing the equipment from the housing in a substantially horizontal direction; and a portable support structure arranged to support the equipment during its withdrawal from the housing. a winch for withdrawing the equipment from the housing in a substantially horizontal direction; and a portable support structure arranged to support the equipment during its withdrawal from the housing.
An air jet loom with a display device, the air jet loom comprising: a weft insertion device causing a weft yarn released from a weft measuring and storing device to move by compressed air injected from a main nozzle and plural sub-nozzles arranged in the direction of weft insertion; a first sensor that is adapted to detect an angular position of the air jet loom at the time of weft insertion completion; a setting device (21, 24, 28, 29, 37, 45) that serves to set pressure or flow rate of the main nozzle and also to set pressure of the sub nozzles; a measuring device (23, 36, 44) that serves to measure pressure or flow rate of the main nozzle and also to measure pressure of the sub nozzles; and a controller storing the measured pressure or flow rate of the main nozzle for each of different predetermined pressures of the sub-nozzles and equipped with a display, characterized in that the controller causes the display to show a line graph representing pressure or flow rate of the main nozzle with which weft insertion is completed at a previously set angular position of the air jet loom for each if the different predetermined pressures of the sub-nozzles. a weft insertion device causing a weft yarn released from a weft measuring and storing device to move by compressed air injected from a main nozzle and plural sub-nozzles arranged in the direction of weft insertion; a first sensor that is adapted to detect an angular position of the air jet loom at the time of weft insertion completion; a setting device (21, 24, 28, 29, 37, 45) that serves to set pressure or flow rate of the main nozzle and also to set pressure of the sub nozzles; a measuring device (23, 36, 44) that serves to measure pressure or flow rate of the main nozzle and also to measure pressure of the sub nozzles; and a controller storing the measured pressure or flow rate of the main nozzle for each of different predetermined pressures of the sub-nozzles and equipped with a display, characterized in that the controller causes the display to show a line graph representing pressure or flow rate of the main nozzle with which weft insertion is completed at a previously set angular position of the air jet loom for each if the different predetermined pressures of the sub-nozzles.
A method comprising: with a mobile device:obtaining an estimated location of a controllable device; storing the estimated location of the controllable device in a memory of the mobile device; processing signals from one or more inertial sensors of the mobile device to characterize one or more gestures as being associated with one or more commands for controlling the controllable device; storing in the memory of the mobile device, the characterized one or more gestures and associated one or more commands for controlling the controllable device; programming the mobile device to initiate one or more of the associated commands to the controllable device based, at least in part, on the one or more characterized gestures; and programming the mobile device to select the controllable device for receiving said one or more commands responsive to orientation of the mobile device with a direction toward the estimated location stored in the memory of the mobile device for the controllable device. with a mobile device:obtaining an estimated location of a controllable device; storing the estimated location of the controllable device in a memory of the mobile device; processing signals from one or more inertial sensors of the mobile device to characterize one or more gestures as being associated with one or more commands for controlling the controllable device; storing in the memory of the mobile device, the characterized one or more gestures and associated one or more commands for controlling the controllable device; programming the mobile device to initiate one or more of the associated commands to the controllable device based, at least in part, on the one or more characterized gestures; and programming the mobile device to select the controllable device for receiving said one or more commands responsive to orientation of the mobile device with a direction toward the estimated location stored in the memory of the mobile device for the controllable device.
A construction system of wooden load-bearing structures, for buildings, said structures being extended from a foundation level to a roof structure, comprising: a. internal uprights, with height equal to one floor, on which support beams rest, b. external uprights, extending from the foundation level up to the roof structure, c. vertical bracing/joining layer, clamped between the internal uprights and the support beams on one side and the external uprights on the other, d. horizontal and/or tilted structures constituted by the double beams (6, 13) of the various floors which rest on the support beams and, by crossing through the bracing/joining layer, clamp in a jaw-like manner the external uprights that are arranged on the structure sides perpendicular to the beams (6, 13) themselves, e. a layer of wooden panels or boards, with the function of distribution of the static and dynamic loads, fixed above the double beams (6, 13). a. internal uprights, with height equal to one floor, on which support beams rest, b. external uprights, extending from the foundation level up to the roof structure, c. vertical bracing/joining layer, clamped between the internal uprights and the support beams on one side and the external uprights on the other, d. horizontal and/or tilted structures constituted by the double beams (6, 13) of the various floors which rest on the support beams and, by crossing through the bracing/joining layer, clamp in a jaw-like manner the external uprights that are arranged on the structure sides perpendicular to the beams (6, 13) themselves, e. a layer of wooden panels or boards, with the function of distribution of the static and dynamic loads, fixed above the double beams (6, 13).
Process for the dimerization of ethylene to 1-butene, comprising bringing ethylene into contact with a catalytic composition comprising: - at least one nickel precursor with an oxidation state of (+II), - at least one phosphine ligand with formula PR 1 R 2 R 3, in which the R 1, R 2 and R 3 groups, which may be identical or different, and which may optionally be bonded together, are chosen - from substituted or unsubstituted aromatic groups optionally containing heteroelements, - and/or from cyclic or non-cyclic, substituted or unsubstituted hydrocarbyl groups optionally containing heteroelements, - and at least one activating agent chosen from the group formed by chlorinated and brominated hydrocarbylaluminium compounds, used alone or as a mixture, said composition having a molar ratio of the phosphine ligand to the nickel precursor of between 5 and 30 and a molar ratio of the activating agent to the phosphine ligand of greater than or equal to 1, the process being carried out at a temperature between 45°C and 250°C. - at least one nickel precursor with an oxidation state of (+II), - at least one phosphine ligand with formula PR 1 R 2 R 3, in which the R 1, R 2 and R 3 groups, which may be identical or different, and which may optionally be bonded together, are chosen - from substituted or unsubstituted aromatic groups optionally containing heteroelements, - and/or from cyclic or non-cyclic, substituted or unsubstituted hydrocarbyl groups optionally containing heteroelements, - from substituted or unsubstituted aromatic groups optionally containing heteroelements, - and/or from cyclic or non-cyclic, substituted or unsubstituted hydrocarbyl groups optionally containing heteroelements, - and at least one activating agent chosen from the group formed by chlorinated and brominated hydrocarbylaluminium compounds, used alone or as a mixture,
A probe assembly comprising: an inlet for receiving an eluent from a chromatography device; an outlet for delivering the eluent to an ion source of a mass spectrometer; and an attachment device for attaching the outlet to the mass spectrometer; wherein the outlet comprises an electrically conductive capillary and an electrically conductive member surrounding at least part of the electrically conductive capillary; wherein the probe assembly comprises an insulating fluid line for transporting eluent from the inlet to the electrically conductive capillary and a joint between the insulating fluid line and the electrically conductive capillary, wherein the joint is downstream of the attachment device; and wherein the electrically conductive member is arranged to be in electrical connection with the electrically conductive capillary; the probe assembly characterised in that the electrically conductive member is arranged to receive a voltage upon connection of the attachment device to the mass spectrometer through an electrically conductive ferrule. an inlet for receiving an eluent from a chromatography device; an outlet for delivering the eluent to an ion source of a mass spectrometer; and an attachment device for attaching the outlet to the mass spectrometer; wherein the outlet comprises an electrically conductive capillary and an electrically conductive member surrounding at least part of the electrically conductive capillary; wherein the probe assembly comprises an insulating fluid line for transporting eluent from the inlet to the electrically conductive capillary and a joint between the insulating fluid line and the electrically conductive capillary, wherein the joint is downstream of the attachment device; and wherein the electrically conductive member is arranged to be in electrical connection with the electrically conductive capillary; the probe assembly characterised in that the electrically conductive member is arranged to receive a voltage upon connection of the attachment device to the mass spectrometer through an electrically conductive ferrule.
A protocol for cryopreservation of shrimp spermatophores or shrimp sperm mass characterized by comprising the steps of: a) placing a sample of shrimp spermatophores or shrimp sperm mass in a tube or cryovial containing an extender aqueous solution for a period of time ranging from 18 to 22 minutes at a temperature of 21 °C to 25 °C preventing the sample from coming into contact with the solution or the inner walls of the tube, said extender aqueous solution comprising 2,125 g/Kg of NaCl, 0,110 g/Kg of KCl, 0,052 g/Kg of H 3 BO 3, 0,019 g/Kg of NaOH, 0,484 g/Kg of MgSO 4 ·7H 2 O and, 20 μl for each 100ml of extender solution from a solution containing 10000 IU of penicillin, 10mg of streptomycin and 25 μg of amphotericin B; b) submerging the sample in Trehalose at 0.25-0.5M for a period of time ranging from 18 to 22 minutes; c) transferring the sample into a cryoprotectant solution comprising 0.25-0.5 M of Trehalose and 10-15% of DMSO in extender solution, submerging only 2/3 of it for a period of time ranging from 2 to 4 minutes; d) removing the sample from the cryoprotectant solution and immediately submerge it in liquid nitrogen; and e) placing the sample in a cryovial and ultimately store it in liquid nitrogen at a temperature ranging from -196 °C to -200 °C. a) placing a sample of shrimp spermatophores or shrimp sperm mass in a tube or cryovial containing an extender aqueous solution for a period of time ranging from 18 to 22 minutes at a temperature of 21 °C to 25 °C preventing the sample from coming into contact with the solution or the inner walls of the tube, said extender aqueous solution comprising 2,125 g/Kg of NaCl, 0,110 g/Kg of KCl, 0,052 g/Kg of H 3 BO 3, 0,019 g/Kg of NaOH, 0,484 g/Kg of MgSO 4 ·7H 2 O and, 20 μl for each 100ml of extender solution from a solution containing 10000 IU of penicillin, 10mg of streptomycin and 25 μg of amphotericin B; b) submerging the sample in Trehalose at 0.25-0.5M for a period of time ranging from 18 to 22 minutes; c) transferring the sample into a cryoprotectant solution comprising 0.25-0.5 M of Trehalose and 10-15% of DMSO in extender solution, submerging only 2/3 of it for a period of time ranging from 2 to 4 minutes; d) removing the sample from the cryoprotectant solution and immediately submerge it in liquid nitrogen; and e) placing the sample in a cryovial and ultimately store it in liquid nitrogen at a temperature ranging from -196 °C to -200 °C.
A fastener for screw fastening to a mounting rail, wherein the fastener has a support that is provided for contact on the outside of the mounting rail and has a through-hole for a threaded rod that can be arranged with the fastener on the mounting rail, wherein the fastener has a hammerhead element that is provided for contact on the inside of the mounting rail, which hammerhead element has a fastening thread that is coaxial with the through-hole of the support and the outer thread diameter of which is not greater than a diameter of the through-hole of the support, and wherein the fastener has a holder for the hammerhead element that connects the hammerhead element to the support such that its distance can be varied with respect to the support and that connects the hammerhead element to the support coaxially with the fastening thread with respect to the through-hole of the support, characterized in that the holder holds the hammerhead element in a first latching position in a position close to the support and in a second latching position in a position remote from the support, wherein the hammerhead element is transferable from the second to the first latching position.