A mobile x-ray radiography apparatus, comprising: a wheeled moveable transport frame; an adjustable support structure coupled to the moveable transport frame; an x-ray source assembly mounted to the adjustable support structure, wherein the adjustable support structure allows movement of the x-ray source assembly over a range of vertical and horizontal positions, wherein the x-ray source assembly is configured to direct x-ray radiation towards a subject from one or a plurality of different source positions, where the x-ray source assembly includes a first x-ray source configured to emit full power x-rays for projection radiography and a plurality of distributed x-ray sources disposed in a prescribed spatial relationship and configured to emit x-rays having a lower power to capture projection image data sets used for reconstruction of tomosynthesis images; control circuitry at the mobile x-ray radiography apparatus and coupled to the x-ray source assembly, the control circuitry configured to receive the projection image data sets used for reconstruction of tomosynthesis images; a portable power supply configured to power the moveable transport frame, control circuitry, the first x-ray source and the plurality of distributed x-ray sources; and a portable human interface device coupled to the control circuitry to control the capture of projection image data sets used for reconstruction of tomosynthesis images, wherein the control circuitry is configured to transmit at least one projection radiography image obtained using the first x-ray source, and to transmit the projection image data sets obtained using the plurality of distributed x-ray sources, to a remote system for processing of projection radiography images and for reconstruction of tomosynthesis images or to process projection radiography images and reconstruct tomosynthesis images at the mobile x-ray apparatus. a wheeled moveable transport frame; an adjustable support structure coupled to the moveable transport frame; an x-ray source assembly mounted to the adjustable support structure, wherein the adjustable support structure allows movement of the x-ray source assembly over a range of vertical and horizontal positions, wherein the x-ray source assembly is configured to direct x-ray radiation towards a subject from one or a plurality of different source positions, where the x-ray source assembly includes a first x-ray source configured to emit full power x-rays for projection radiography and a plurality of distributed x-ray sources disposed in a prescribed spatial relationship and configured to emit x-rays having a lower power to capture projection image data sets used for reconstruction of tomosynthesis images; control circuitry at the mobile x-ray radiography apparatus and coupled to the x-ray source assembly, the control circuitry configured to receive the projection image data sets used for reconstruction of tomosynthesis images; a portable power supply configured to power the moveable transport frame, control circuitry, the first x-ray source and the plurality of distributed x-ray sources; and a portable human interface device coupled to the control circuitry to control the capture of projection image data sets used for reconstruction of tomosynthesis images, wherein the control circuitry is configured to transmit at least one projection radiography image obtained using the first x-ray source, and to transmit the projection image data sets obtained using the plurality of distributed x-ray sources, to a remote system for processing of projection radiography images and for reconstruction of tomosynthesis images or to process projection radiography images and reconstruct tomosynthesis images at the mobile x-ray apparatus.