A process of close-up inspection of at least one skin lesion within a region on a skin surface, the region containing multiple skin lesions, the process comprising: • in a handheld inspection device (104A-104D), positioned by a user at a remote distance from the skin surface, the remote distance being effective for acquiring an image of the region by the handheld inspection device: acquiring an image of the region; • in a processor (108,158): selecting a target skin lesion within the image of the region; • on a screen (116A-116D, 166): ∘ displaying the image of the region, and ∘ marking the target skin lesion within the image of the region, to visually distinguish the target skin lesion from other skin lesions within the region; • in the handheld inspection device (104A-104D): in a close distance that is less than the remote distance and is sufficiently close to the skin surface for performing a close-up inspection of the target skin lesion: performing the close-up inspection of the target skin lesion; • while the handheld inspection device (104A-104D) is moved by the user toward the skin surface: ∘ in the handheld inspection device (104A-104D): continuously acquiring a current image of the skin surface, and ∘ in the processor (108, 158) and on the screen (116A-116D, 166): showing and marking the target skin lesion within the current image of the skin surface, and, if the target skin lesion is not included within the current image of the skin surface, interrupting the process of close-up inspection and instructing the user to restart the process of close-up inspection from a remote distance.; and • in the handheld inspection device (104A-104D): in a close distance that is less than the remote distance and is sufficiently close to the skin surface for performing a close-up inspection of the target skin lesion: performing the close-up inspection of the target skin lesion. • in a handheld inspection device (104A-104D), positioned by a user at a remote distance from the skin surface, the remote distance being effective for acquiring an image of the region by the handheld inspection device: acquiring an image of the region; • in a processor (108,158): selecting a target skin lesion within the image of the region; • on a screen (116A-116D, 166): ∘ displaying the image of the region, and ∘ marking the target skin lesion within the image of the region, to visually distinguish the target skin lesion from other skin lesions within the region; ∘ displaying the image of the region, and ∘ marking the target skin lesion within the image of the region, to visually distinguish the target skin lesion from other skin lesions within the region; • in the handheld inspection device (104A-104D): in a close distance that is less than the remote distance and is sufficiently close to the skin surface for performing a close-up inspection of the target skin lesion: performing the close-up inspection of the target skin lesion; • while the handheld inspection device (104A-104D) is moved by the user toward the skin surface: ∘ in the handheld inspection device (104A-104D): continuously acquiring a current image of the skin surface, and ∘ in the processor (108, 158) and on the screen (116A-116D, 166): showing and marking the target skin lesion within the current image of the skin surface, and, if the target skin lesion is not included within the current image of the skin surface, interrupting the process of close-up inspection and instructing the user to restart the process of close-up inspection from a remote distance.; and ∘ in the handheld inspection device (104A-104D): continuously acquiring a current image of the skin surface, and ∘ in the processor (108, 158) and on the screen (116A-116D, 166): showing and marking the target skin lesion within the current image of the skin surface, and, if the target skin lesion is not included within the current image of the skin surface, interrupting the process of close-up inspection and instructing the user to restart the process of close-up inspection from a remote distance.; and • in the handheld inspection device (104A-104D): in a close distance that is less than the remote distance and is sufficiently close to the skin surface for performing a close-up inspection of the target skin lesion: performing the close-up inspection of the target skin lesion.