A compound selected from compounds of Formula I: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein: Q is selected from C and N; W is selected from C and N; X is selected from CH 2 and O; Y is selected from NR 12, O, and S; Z is selected from O, S, NR 13, CO, SO, SO 2, and CR 13 R 14; R 1, R 2, R 3, R 4, R 5, and R 6, which may be the same or different, are each selected from hydrogen, halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, alkynyl, - CN, -NR 13 R 14, -OR 13, -COR 13, -CO 2 R 13, -CONR 13 R 14, -C(=NR 13)NR 14 R 15 -NR 13 COR 14,- NR 13 CONR 14 R 15, -NR 13 CO 2 R 14, -SO 2 R 13, -NR 13 SO 2 NR 14 R 15, -NR 13 SO 2 R 14, and -NR 13 SO 2 aryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, aryl, and heterocyclyl are optionally substituted with at least one substituent R 16, or (R 1 and R 2), and /or (R 3 and R 4), and /or (R 5 and R 6), together with the ring to which they are attached, form a fused ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R 16; provided that R 1 is absent when Q is N, and R 5 is absent when W is N; R 7 is selected from hydrogen, halogen, alkyl, -O-alkyl, and -S-alkyl; R 12 is selected from hydrogen and alkyl; R 13, R 14 and R 15, which may be the same or different, are each selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl; or (R 13 and R 14), and /or (R 14 and R 15) together with the atom(s) to which they are attached, each form a ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R 16; R 16 is selected from halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkynyl, oxo, -CN, -OR', -NR'R", -COR', -CO 2 R', -CONR'R", -C(=NR')NR"R"', - NR'COR", -NR'CONR'R", -NR'CO 2 R" -SO 2 R' -SO 2 aryl, -NR'SO 2 NR"R"', NR'SO 2 R", and - NR'SO 2 aryl, wherein R', R", and R'" are independently selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or (R' and R"), and /or (R" and R"') together with the atoms to which they are attached, form a ring selected from heterocyclyl, and heteroaryl rings. Q is selected from C and N; W is selected from C and N; X is selected from CH 2 and O; Y is selected from NR 12, O, and S; Z is selected from O, S, NR 13, CO, SO, SO 2, and CR 13 R 14; R 1, R 2, R 3, R 4, R 5, and R 6, which may be the same or different, are each selected from hydrogen, halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, alkynyl, - CN, -NR 13 R 14, -OR 13, -COR 13, -CO 2 R 13, -CONR 13 R 14, -C(=NR 13)NR 14 R 15 -NR 13 COR 14,- NR 13 CONR 14 R 15, -NR 13 CO 2 R 14, -SO 2 R 13, -NR 13 SO 2 NR 14 R 15, -NR 13 SO 2 R 14, and -NR 13 SO 2 aryl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, aryl, and heterocyclyl are optionally substituted with at least one substituent R 16, or (R 1 and R 2), and /or (R 3 and R 4), and /or (R 5 and R 6), together with the ring to which they are attached, form a fused ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R 16; provided that R 1 is absent when Q is N, and R 5 is absent when W is N; R 7 is selected from hydrogen, halogen, alkyl, -O-alkyl, and -S-alkyl; R 12 is selected from hydrogen and alkyl; R 13, R 14 and R 15, which may be the same or different, are each selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl; or (R 13 and R 14), and /or (R 14 and R 15) together with the atom(s) to which they are attached, each form a ring selected from heterocyclyl, and heteroaryl rings optionally substituted with at least one substituent R 16; R 16 is selected from halogen, haloalkyl, alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkynyl, oxo, -CN, -OR', -NR'R", -COR', -CO 2 R', -CONR'R", -C(=NR')NR"R"', - NR'COR", -NR'CONR'R", -NR'CO 2 R" -SO 2 R' -SO 2 aryl, -NR'SO 2 NR"R"', NR'SO 2 R", and - NR'SO 2 aryl, wherein R', R", and R'" are independently selected from H, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or (R' and R"), and /or (R" and R"') together with the atoms to which they are attached, form a ring selected from heterocyclyl, and heteroaryl rings.