mhurhangee/ep-ind-claims huggingface dataset:
An apparatus for producing two beams of x-ray radiation comprising first and second tubes for generating x-rays (32, 32'), the first and second tubes (32, 32') being placed in an abutting position with the target of the first tube facing away from the second tube, and the target of the second tube facing away from the first tube, the rotational axes (54, 54') of the rotating systems of the first and second tubes (32, 32') being collinear; each tube (32, 32') comprising: a cathode (42, 42') adapted to emit electrons; a target (40, 40') comprising a target material (46, 46'), wherein the target (40, 40') is positioned to receive the electrons from the cathode (42, 42') on a surface (50, 50') thereof at a focal point (48, 48'); an anode (43, 43') adapted with an aperture (52, 52') and positioned between the cathode (42, 42') and the target (40, 40') and configured to accelerate the electrons toward the target (40, 40'); and a rotating system (56, 56') adapted to rotate the target (40, 40') about an axis (54, 54'), the rotating system (56, 56') attached to the target (40, 40') and located in a position facing said surface (50, 50') of the target (40, 40') that is positioned to receive the electrons from the cathode (42, 42'); wherein a longitudinal axis of the cathode (42, 42') is parallel to the axis of rotation (54, 54') of the target (40, 40'); and the cathode (42, 42') and the rotating system (56, 56') face the surface (50, 50') of the target (40, 40'); such that the distance between the focal points (48, 48') is in a range of 60-120mm. a cathode (42, 42') adapted to emit electrons; a target (40, 40') comprising a target material (46, 46'), wherein the target (40, 40') is positioned to receive the electrons from the cathode (42, 42') on a surface (50, 50') thereof at a focal point (48, 48'); an anode (43, 43') adapted with an aperture (52, 52') and positioned between the cathode (42, 42') and the target (40, 40') and configured to accelerate the electrons toward the target (40, 40'); and a rotating system (56, 56') adapted to rotate the target (40, 40') about an axis (54, 54'), the rotating system (56, 56') attached to the target (40, 40') and located in a position facing said surface (50, 50') of the target (40, 40') that is positioned to receive the electrons from the cathode (42, 42'); wherein a longitudinal axis of the cathode (42, 42') is parallel to the axis of rotation (54, 54') of the target (40, 40'); and the cathode (42, 42') and the rotating system (56, 56') face the surface (50, 50') of the target (40, 40'); such that the distance between the focal points (48, 48') is in a range of 60-120mm.
A method of identifying subject specific T cell receptor pairs suitable for subject specific cancer therapy, the method comprising: (a) determining by single cell sequencing the sequences encoding the TCR pairs on individual cells in a population of T cells isolated from a human subject; (b) transfecting or transducing T cells with the sequences encoding individual TCR pairs determined in (a); and (c) using the T cells from (b) to assay binding of the subject specific TCR pairs to subject specific neoepitopes and selecting the TCR pairs that bind to subject specific neoepitopes. (a) determining by single cell sequencing the sequences encoding the TCR pairs on individual cells in a population of T cells isolated from a human subject; (b) transfecting or transducing T cells with the sequences encoding individual TCR pairs determined in (a); and (c) using the T cells from (b) to assay binding of the subject specific TCR pairs to subject specific neoepitopes and selecting the TCR pairs that bind to subject specific neoepitopes.
A blasting system which includes at least one detonator, a blast energy source, a connection between the blast energy source and the at least one detonator, and control equipment (16, 18) for controlling initiation of the at least one detonator by causing energy from the blast energy source to be supplied to the at least one detonator, and wherein at least one component (42, 42A, 42B) of the blasting system is physically movable from an operative position to a safe position, which is visible by an operator, at which blast energy from the energy source cannot be supplied to the at least one detonator, and which is characterised in that the blasting system includes one solenoid which, when energised keeps the component in the operative position, and a biasing mechanism which moves the component (42, 42A, 42B) from the operative position automatically to the safe position when the one solenoid is de-energised, and wherein the component is selected from a plunger with a conductor embedded therein wherein the one solenoid and a second solenoid are mounted to a base of the said plunger and a structure (96,96B) carrying the blast energy source, a blast energy converter or a connector link.
A method of making a stent-graft with an inner layer and an outer layer where the outer layer is less porous than the inner layer, comprising: applying a first charge to a mandrel; applying a second charge to a first needle; rotating and translating said mandrel and said first needle relative to each other; dispensing a first polymer mixed with a first solvent through said first needle at a first flow rate, a first layer of fibers thereby being electrospun onto said mandrel; disposing a stent onto said first layer; applying a third charge to said mandrel; applying a fourth charge to a second needle; rotating and translating said mandrel and said second needle relative to each other; dispensing a second polymer mixed with a second solvent through said second needle at a second flow rate, a second layer of fibers thereby being electrospun onto said stent; and wherein said second needle has a larger lumen than said first needle and said second flow rate is higher than said first flow rate. applying a first charge to a mandrel; applying a second charge to a first needle; rotating and translating said mandrel and said first needle relative to each other; dispensing a first polymer mixed with a first solvent through said first needle at a first flow rate, a first layer of fibers thereby being electrospun onto said mandrel; disposing a stent onto said first layer; applying a third charge to said mandrel; applying a fourth charge to a second needle; rotating and translating said mandrel and said second needle relative to each other; dispensing a second polymer mixed with a second solvent through said second needle at a second flow rate, a second layer of fibers thereby being electrospun onto said stent; and wherein said second needle has a larger lumen than said first needle and said second flow rate is higher than said first flow rate.
A floor cleaning head comprising a body portion and a nozzle portion attached to the body portion, the nozzle portion comprising: front and rear transversely extending elongate blades (33,34) formed of a resiliently flexible material depending from the underside thereof; and a suction mouth disposed on the underside thereof between said blades (33,34); characterised in that the nozzle portion is pivotally attached to the body portion for rotation about a transverse axis (x - x) which extends parallel to the suction mouth, means being provided for pivoting the nozzle portion in a first direction such that the suction mouth faces forwardly and the front blade is raised away from a floor surface when the head is moved forwardly across the surface and for pivoting the nozzle portion in a second direction such that the suction mouth faces rearwardly and the rear blade is raised away from the floor surface when the head is moved rearwardly across the surface. front and rear transversely extending elongate blades (33,34) formed of a resiliently flexible material depending from the underside thereof; and a suction mouth disposed on the underside thereof between said blades (33,34);
Sequentially operating waste water treatment plant for the biological purification of waste water, adapted for the withdrawal of clear water whilst dispensing with a pump or an air-lift pump and the valves required for control thereof, comprising - a reactor vessel for receiving waste water, comprising an inlet (2.1) for the untreated waste water and an outlet (2.2) for the treated waste water, wherein the outlet (2.2) is arranged underneath the inlet (2.1) in the reactor vessel, - an aeration device for introducing air into the waste water which is arranged on the base of the rector vessel, - a drainage device arranged movably in the reactor vessel having a drain inlet (5.3) for the treated waste water, - a fluid-conducting connection between the drain inlet (5.3) of the drainage device and the outlet (2.2), - an aeratable and ventable lifting device for the drainage device which by aerating lifts the drain inlet (5.3) of the drainage device completely out of the waste water and by venting immerses the drain inlet (5.3) of the drainage device into the waste water, wherein the lifting device is an inflatable floating body, - a compressed air supply adapted for aerating both the lifting device and also the aeration device, - a throttle adapted for time-delayed venting of the lifting device after the end of the aeration, wherein the throttle is an exhaust air opening in the floating body having a cross-section that is determined in such a manner that an air stream permanently escapes from the floating body that is always smaller than the air stream supplied during aeration and - a controller for the temporary operation of the compressed air supply. - a reactor vessel for receiving waste water, comprising an inlet (2.1) for the untreated waste water and an outlet (2.2) for the treated waste water, wherein the outlet (2.2) is arranged underneath the inlet (2.1) in the reactor vessel, - an aeration device for introducing air into the waste water which is arranged on the base of the rector vessel, - a drainage device arranged movably in the reactor vessel having a drain inlet (5.3) for the treated waste water, - a fluid-conducting connection between the drain inlet (5.3) of the drainage device and the outlet (2.2), - an aeratable and ventable lifting device for the drainage device which by aerating lifts the drain inlet (5.3) of the drainage device completely out of the waste water and by venting immerses the drain inlet (5.3) of the drainage device into the waste water, wherein the lifting device is an inflatable floating body, - a compressed air supply adapted for aerating both the lifting device and also the aeration device, - a throttle adapted for time-delayed venting of the lifting device after the end of the aeration, wherein the throttle is an exhaust air opening in the floating body having a cross-section that is determined in such a manner that an air stream permanently escapes from the floating body that is always smaller than the air stream supplied during aeration and - a controller for the temporary operation of the compressed air supply.
Case for remote control units, comprising at least a cover wrapping for covering the substantial totality of a remote control unit having at least a pushbutton panel, said cover wrapping comprising at least a sector which is at least partially transparent and can be placed in correspondence to said pushbutton panel of the remote control unit to permit the view of said pushbutton panel, characterized by the fact that it comprises at least a covering element which is associated in a removable way with said cover wrapping substantially in correspondence to said sector and suitable for preventing said pushbutton panel from being viewed as long as said covering element is not removed from said cover wrapping.
Security element (92, 95, 97) in the form of a multilayer film body, in particular a laminating film or transfer film, having an upper side facing towards the observer and a volume hologram which provides a first optically variable piece of information, wherein the security element (92, 95, 97) has a layer, having a surface which has a relief structure (22, 23, 24) which has a relief depth of more than 0 in one or more first regions, and has a relief depth of less than 2μm in one or more second regions, and the relief structure (22, 23, 24)is filled with a volume-hologram material in the first regions of the layer, in which volume-hologram material the volume hologram is recorded, characterised in that the layer is a replicating layer, in the surface of which the relief structure (22, 23, 24) is moulded, the relief structure (23, 24) has a relief depth of more than 10μm in the first regions, and has structural elements in the second regions or in sub-regions of the second regions, said structural elements providing a second optically variable piece of information, and a metallic layer is provided in the second regions or in sub-regions of the second regions, and the metallic layer is not provided in the first regions.
A wearable package comprising: • a sealed first compartment for housing a product; • a second compartment for housing a bi-stable band, • the bi-stable band positioned within the second compartment, wherein the second compartment comprises an elongated opening configured and arranged in the second compartment for accepting the bi-stable band, wherein the package is so constructed and arranged to be worn by a consumer. • a sealed first compartment for housing a product; • a second compartment for housing a bi-stable band, • the bi-stable band positioned within the second compartment, wherein the second compartment comprises an elongated opening configured and arranged in the second compartment for accepting the bi-stable band, wherein the package is so constructed and arranged to be worn by a consumer.
A probiotic bacterial composition comprising bacteria selected from the group consisting of Bacteroidesfragilis, Bacteroides thetaiotaomicron, Burkholderia cepacia and mixtures thereof, for use for treating a cancer, in combination with an anti-CTLA4 antibody blocking CTLA4.
A process for obtaining an insulating glazing comprising first and second glass sheets (2, 3) that are held parallelly spaced apart with the aid of at least one transparent glass spacer adhesively bonded to the periphery of said glass sheets (2, 3) so as to make a gas-filled interlayer space, said process comprising the following steps: - a step of providing said spacer, said spacer being substantially parallelepipedal and comprising at least two rough faces (41, 42) opposite one another, and two smooth faces (43, 44) opposite one another, then - a step of assembling said at least one spacer between the glass sheets (2, 3), so that each rough face (41, 42) of said spacer is positioned close to an edge, and against a face (21, 31), referred to as an inner face, of each of said glass sheets (2, 3), the interstitial width between the rough faces (41, 42) of the spacer and the inner faces (21, 31) of the glass sheets (2, 3) being less than 0.01 mm, then - a step of depositing, at the external joint lines (24, 34) between the rough faces of the spacer and the inner faces of the glass sheets, a transparent adhesive, said adhesive moving by capillary action so as to cover the surface of said rough faces of the spacer, then - at least one step of curing said adhesive; at the end of the assembling step, the interstitial width between the rough faces of the spacer and the inner faces of the glass sheets should be at most 0.01 mm, over the entire length of the spacer, therefore generally over the entire length of the edge of the glass sheet in the vicinity of which the spacer is placed. - a step of providing said spacer, said spacer being substantially parallelepipedal and comprising at least two rough faces (41, 42) opposite one another, and two smooth faces (43, 44) opposite one another, then - a step of assembling said at least one spacer between the glass sheets (2, 3), so that each rough face (41, 42) of said spacer is positioned close to an edge, and against a face (21, 31), referred to as an inner face, of each of said glass sheets (2, 3), the interstitial width between the rough faces (41, 42) of the spacer and the inner faces (21, 31) of the glass sheets (2, 3) being less than 0.01 mm, then - a step of depositing, at the external joint lines (24, 34) between the rough faces of the spacer and the inner faces of the glass sheets, a transparent adhesive, said adhesive moving by capillary action so as to cover the surface of said rough faces of the spacer, then - at least one step of curing said adhesive;
An authentication method in an Enrollment over Secured Transport, EST, solution based on a constraint network protocol to be applied to a constraint network in an internet of things environment, comprising: receiving, by a first network node being an EST server, an enrollment request from a second network node, being an EST client; obtaining, by the first network node, position information of the second network node; and authenticating, by the first network node, the second network node according to the obtained position information of the second network node, when for the authentication the first network node determines that the second network node is within a preset trustable region, wherein when establishing a bottomlayer Datagram Transport Layer Security, DTLS, connection to the second network node, the first network node does not provide a certificate, and the first network node determines the position information of the second network node to perform the authentication operation. receiving, by a first network node being an EST server, an enrollment request from a second network node, being an EST client; obtaining, by the first network node, position information of the second network node; and authenticating, by the first network node, the second network node according to the obtained position information of the second network node, when for the authentication the first network node determines that the second network node is within a preset trustable region, wherein when establishing a bottomlayer Datagram Transport Layer Security, DTLS, connection to the second network node, the first network node does not provide a certificate, and the first network node determines the position information of the second network node to perform the authentication operation.
A method for preparing the intermediate of roxadustat of formula 34, characterized in that the intermediate of formula 32 is converted in an acidic medium to an intermediate of formula 33, which spontaneously cyclizes to the intermediate of formula 34, wherein R 1 is halogen, PhO, OH or a protected hydroxyl group; R 2 is H or a C1 -C10 alkyl group; R 3 is H or a C1 -C10 alkyl group or aryl group; A is a precursor of an acetyl group, preferably a group A1, wherein R 4 is a C1-C10 alkyl group; A2, where n = 1 to 5; A3, wherein PG is a protecting group, preferably SiR 5 R 6 R 7 or CR 8 R 9 OH, where R 5 to R 9 is a C1-C10 alkyl group; or A4 R 1 is halogen, PhO, OH or a protected hydroxyl group; R 2 is H or a C1 -C10 alkyl group; R 3 is H or a C1 -C10 alkyl group or aryl group; A is a precursor of an acetyl group, preferably a group A1, wherein R 4 is a C1-C10 alkyl group; A2, where n = 1 to 5; A3, wherein PG is a protecting group, preferably SiR 5 R 6 R 7 or CR 8 R 9 OH, where R 5 to R 9 is a C1-C10 alkyl group; or A4 A1, wherein R 4 is a C1-C10 alkyl group; A2, where n = 1 to 5; A3, wherein PG is a protecting group, preferably SiR 5 R 6 R 7 or CR 8 R 9 OH, where R 5 to R 9 is a C1-C10 alkyl group; or A4
Wind turbine comprising at least two communication protocol handlers, each of said protocol handlers comprising means for generating and interpreting Supervisory Control And Data Acquisition, SCADA, related data according to an associated communication protocol, wherein said at least two protocol handlers are associated to different communication protocols, and wherein said protocol handlers are comprised by a SCADA interface, wherein the two different communication protocols are utilized simultaneously and have different communication priorities of the data.
Method for operating a network-infrastructure network unit of a cell-based wireless communication network (CELL), the method comprising: - receiving (202; 708; 720) a scheduling request message (BSR1; BSR2) for a sidelink channel in an unlicensed frequency band (NLFB) from a roadside network unit on an uplink channel, the scheduling request message (BSR1; BSR2) indicating a size of data (D1; D2) that are available at the roadside network unit for sending on the sidelink channel; - ascertaining (204; 710; 722) a scheduling grant message on the basis of the size of the available data (D1; D2), the scheduling grant message comprising an allocation of a number of sidelink resources (SRR1; SRR2; SRR3) of the sidelink channel to the roadside network unit, and the allocated number of sidelink resources (SRR1; SRR2; SRR3) being sufficient to send the available data (D1; D2) and further data from other roadside network units (NE1; NE2); and - sending (206; 712; 724) the scheduling grant message to the roadside network unit on a downlink channel. - receiving (202; 708; 720) a scheduling request message (BSR1; BSR2) for a sidelink channel in an unlicensed frequency band (NLFB) from a roadside network unit on an uplink channel, the scheduling request message (BSR1; BSR2) indicating a size of data (D1; D2) that are available at the roadside network unit for sending on the sidelink channel; - ascertaining (204; 710; 722) a scheduling grant message on the basis of the size of the available data (D1; D2), the scheduling grant message comprising an allocation of a number of sidelink resources (SRR1; SRR2; SRR3) of the sidelink channel to the roadside network unit, and the allocated number of sidelink resources (SRR1; SRR2; SRR3) being sufficient to send the available data (D1; D2) and further data from other roadside network units (NE1; NE2); and - sending (206; 712; 724) the scheduling grant message to the roadside network unit on a downlink channel.
Fuel cell comprising two plates sandwiching an electrode membrane assembly, characterised in that the plates each comprise a reactive face intended to convey an oxidising gas or a fuel gas to an electrode membrane assembly, the reactive face comprising projecting ridges delimiting channels provided for the circulation of gas, over at least part of their height the ridges having a width decreasing in the direction of their apex on a cutting plane perpendicular to the plane of the plate and perpendicular to the circulation axis of the channel delimited by the ridges in question, the top of the ridges being curved and convex, the ridges having a section delimited by a curve with a roughly sinusoidal shape on a cutting plane perpendicular to the plane of the plate and perpendicular to the circulation axis of the channel delimited by the ridges in question, the top ends of the ridges being curved at the junction between the flanks and the top of the ridges, the bottom ends of the ridges being curved at the junction between the flanks of the ridges and the surface of the plate delimiting the bottom of the channels, characterised in that, in cross section along a plane perpendicular to the plane of the plate and perpendicular to the circulation axis of the channel delimited by the ridges in question, the width of the channels halfway up the ridges is between 1 and 1.5 mm, and in that, on a plane perpendicular to the plane of the plate and perpendicular to the circulation axis of the channel delimited by the ridges in question, the ridges have, halfway up, a width of between 0.5 and 1 mm, and in that the flanks of the ridges are inclined with respect to the direction perpendicular to the plane of the plate at an angle of between 5 and 50 degrees and preferably between 10 and 30 degrees, and in that, in cross section on a plane perpendicular to the plane of the plate and perpendicular to the circulation axis of the channel delimited by the ridges in question, the bottom of the channel and the ridges are connected in a continuously curved fashion on a profile with a roughly sinusoidal shape.