A system for acquisition and co-registered display of intravascular information, comprising: an imaging flexible elongate member having a proximal end and a distal end; an imaging probe located near the distal end of the flexible elongate member, and configured to obtain information for generating an image of a vessel; a radiopaque marker located near the imaging probe; a first memory for storing angiogram image data; a second memory for storing intravascular image data derived from information obtained by the imaging probe; characterized in a third memory for storing fluoroscopic image data, distinct from the angiogram image data, comprising radiopaque marker image data being derived from information obtained from a fluoroscopic imaging device; a display processor that combines data retrieved from the first memory and second memory, and the third memory to render a composite image including: an enhanced radiological image (410, 510) derived from the angiogram image data comprising a superposition of at least a portion of the angiogram data and the radiopaque marker image data and providing a location of the radiopaque marker based upon an actual location during active fluoroscopy and an estimated location during inactive fluoroscopy based upon its last registered position and other indicators of catheter movement; an intravascular image element corresponding to the intravascular image data, wherein the enhanced radiological image (410, 510) and the intravascular image element are displayed proximate each other; and a cursor (420, 520), displayed upon the enhanced radiological image (410, 510), indicative of a location of the imaging probe while acquiring data for the intravascular image element presently displayed on the composite image said cursor (420, 520) having a position that is based at least in part on third data derived from the radiopaque marker image data stored in the third memory; wherein an error is calculated based on a difference between the estimated location of the radiopaque marker and the actual location of the radiopaque marker when active fluoroscopy is resumed after inactive fluoroscopy and wherein the error is utilized to correct the estimated location of the radiopaque marker for the preceding period of inactive fluoroscopy. an imaging flexible elongate member having a proximal end and a distal end; an imaging probe located near the distal end of the flexible elongate member, and configured to obtain information for generating an image of a vessel; a radiopaque marker located near the imaging probe; a first memory for storing angiogram image data; a second memory for storing intravascular image data derived from information obtained by the imaging probe; a third memory for storing fluoroscopic image data, distinct from the angiogram image data, comprising radiopaque marker image data being derived from information obtained from a fluoroscopic imaging device; a display processor that combines data retrieved from the first memory and second memory, and the third memory to render a composite image including: an enhanced radiological image (410, 510) derived from the angiogram image data comprising a superposition of at least a portion of the angiogram data and the radiopaque marker image data and providing a location of the radiopaque marker based upon an actual location during active fluoroscopy and an estimated location during inactive fluoroscopy based upon its last registered position and other indicators of catheter movement; an intravascular image element corresponding to the intravascular image data, wherein the enhanced radiological image (410, 510) and the intravascular image element are displayed proximate each other; and a cursor (420, 520), displayed upon the enhanced radiological image (410, 510), indicative of a location of the imaging probe while acquiring data for the intravascular image element presently displayed on the composite image said cursor (420, 520) having a position that is based at least in part on third data derived from the radiopaque marker image data stored in the third memory; wherein an error is calculated based on a difference between the estimated location of the radiopaque marker and the actual location of the radiopaque marker when active fluoroscopy is resumed after inactive fluoroscopy and wherein the error is utilized to correct the estimated location of the radiopaque marker for the preceding period of inactive fluoroscopy. an enhanced radiological image (410, 510) derived from the angiogram image data comprising a superposition of at least a portion of the angiogram data and the radiopaque marker image data and providing a location of the radiopaque marker based upon an actual location during active fluoroscopy and an estimated location during inactive fluoroscopy based upon its last registered position and other indicators of catheter movement; an intravascular image element corresponding to the intravascular image data, wherein the enhanced radiological image (410, 510) and the intravascular image element are displayed proximate each other; and a cursor (420, 520), displayed upon the enhanced radiological image (410, 510), indicative of a location of the imaging probe while acquiring data for the intravascular image element presently displayed on the composite image said cursor (420, 520) having a position that is based at least in part on third data derived from the radiopaque marker image data stored in the third memory;