A positioning method, wherein the method comprises: separately obtaining, by a positioning server, location coordinates of M positioning nodes; separately obtaining, by the positioning server, a reference signal time difference, RSTD, between an i th positioning node and an (i+1) th positioning node in the M positioning nodes and a j th mobile terminal in two mobile terminals, wherein M is an integer and M ≥ 5, i is separately set to each of all integers ranging from 1 to M-1, and j is separately set to 1 or 2; determining, by the positioning server, a relative RSTD according to the RSTD, wherein the relative RSTD indicates a difference between an RSTD between the i th positioning node and the (i+1) th positioning node and a first mobile terminal in the two mobile terminals and an RSTD between the i th positioning node and the (i+1) th positioning node and a second mobile terminal in the two mobile terminals; and determining, by the positioning server, location coordinates of the two mobile terminals according to the relative RSTD and the location coordinates of the M positioning nodes; wherein the separately obtaining, by the positioning server, a reference signal time difference RSTD between an i th positioning node and an (i+1) th positioning node in the M positioning nodes and a j th mobile terminal in two mobile terminals comprises: separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, wherein the ToAs of the uplink pilot signals are obtained by the M positioning nodes by separately measuring the uplink pilot signals sent by the two mobile terminals; and determining, by the positioning server, an RSTD between the i th positioning node and the (i+1) th positioning node and the j th mobile terminal in the two mobile terminals according to the ToAs of the uplink pilot signals; wherein before the separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, the method further comprises: separately sending, by the positioning server, a first message to the two mobile terminals, so that the two mobile terminals simultaneously send the uplink pilot signals to the M positioning nodes. separately obtaining, by a positioning server, location coordinates of M positioning nodes; separately obtaining, by the positioning server, a reference signal time difference, RSTD, between an i th positioning node and an (i+1) th positioning node in the M positioning nodes and a j th mobile terminal in two mobile terminals, wherein M is an integer and M ≥ 5, i is separately set to each of all integers ranging from 1 to M-1, and j is separately set to 1 or 2; determining, by the positioning server, a relative RSTD according to the RSTD, wherein the relative RSTD indicates a difference between an RSTD between the i th positioning node and the (i+1) th positioning node and a first mobile terminal in the two mobile terminals and an RSTD between the i th positioning node and the (i+1) th positioning node and a second mobile terminal in the two mobile terminals; and determining, by the positioning server, location coordinates of the two mobile terminals according to the relative RSTD and the location coordinates of the M positioning nodes; wherein the separately obtaining, by the positioning server, a reference signal time difference RSTD between an i th positioning node and an (i+1) th positioning node in the M positioning nodes and a j th mobile terminal in two mobile terminals comprises: separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, wherein the ToAs of the uplink pilot signals are obtained by the M positioning nodes by separately measuring the uplink pilot signals sent by the two mobile terminals; and determining, by the positioning server, an RSTD between the i th positioning node and the (i+1) th positioning node and the j th mobile terminal in the two mobile terminals according to the ToAs of the uplink pilot signals; wherein before the separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, the method further comprises: separately sending, by the positioning server, a first message to the two mobile terminals, so that the two mobile terminals simultaneously send the uplink pilot signals to the M positioning nodes. separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, wherein the ToAs of the uplink pilot signals are obtained by the M positioning nodes by separately measuring the uplink pilot signals sent by the two mobile terminals; and determining, by the positioning server, an RSTD between the i th positioning node and the (i+1) th positioning node and the j th mobile terminal in the two mobile terminals according to the ToAs of the uplink pilot signals; wherein before the separately receiving, by the positioning server, times of arrival ToAs that are of uplink pilot signals and that are sent by the M positioning nodes, the method further comprises: separately sending, by the positioning server, a first message to the two mobile terminals, so that the two mobile terminals simultaneously send the uplink pilot signals to the M positioning nodes.