A computed tomography imaging system, comprising: a radiation source configured to emit X-ray radiation; a pixelated detector configured to generate signals in response to the emitted radiation, wherein the pixelated detector comprises a plurality of detector elements, each detector element comprising a plurality of segments disposed at a plurality of depths with respect to a direction of X-ray propagation and with respect to the surface of the detector element facing the radiation source, wherein at least a portion of the detector elements are separated by radiation blocking plates in at least one dimension: a processing component configured to receive signals read out from the pixelated detector, wherein a signal is read out for each segment of each detector element, and wherein for each detector element the processing component: estimates a scatter signal at one or more segments of the detector element; based upon the estimated scatter signal at the one or more segments, estimates a primary signal substantially free of scatter at one or more segments to generate scatter-corrected readout signals for the detector element; and for the combined scatter corrected readout signals from each detector element, reconstructs an image using the scatter corrected readout signals, and characterized in that: the estimation of the scatter signal is based on a calculated acceptance angle of the respective segment of the detector element, wherein the acceptance angle depends on the depth of the respective segment of the detector element. a radiation source configured to emit X-ray radiation; a pixelated detector configured to generate signals in response to the emitted radiation, wherein the pixelated detector comprises a plurality of detector elements, each detector element comprising a plurality of segments disposed at a plurality of depths with respect to a direction of X-ray propagation and with respect to the surface of the detector element facing the radiation source, wherein at least a portion of the detector elements are separated by radiation blocking plates in at least one dimension: a processing component configured to receive signals read out from the pixelated detector, wherein a signal is read out for each segment of each detector element, and wherein for each detector element the processing component: estimates a scatter signal at one or more segments of the detector element; based upon the estimated scatter signal at the one or more segments, estimates a primary signal substantially free of scatter at one or more segments to generate scatter-corrected readout signals for the detector element; and for the combined scatter corrected readout signals from each detector element, reconstructs an image using the scatter corrected readout signals, and characterized in that: the estimation of the scatter signal is based on a calculated acceptance angle of the respective segment of the detector element, wherein the acceptance angle depends on the depth of the respective segment of the detector element. estimates a scatter signal at one or more segments of the detector element; based upon the estimated scatter signal at the one or more segments, estimates a primary signal substantially free of scatter at one or more segments to generate scatter-corrected readout signals for the detector element; and for the combined scatter corrected readout signals from each detector element, reconstructs an image using the scatter corrected readout signals, and characterized in that: the estimation of the scatter signal is based on a calculated acceptance angle of the respective segment of the detector element, wherein the acceptance angle depends on the depth of the respective segment of the detector element.