A compound, wherein the compound is a compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: R 1 is a C 1-6 aliphatic group, wherein R 1 is optionally substituted with up to 2 groups independently selected from -OR, -OR 4, or -C 1-3 haloalkyl; each R is independently hydrogen or a C 1-6 aliphatic; each R 2 is independently R, fluoro, or chloro; m is 0, 1, or 2; R 3 is hydrogen, C 1-3 aliphatic, fluoro, or chloro; each R 4 is independently hydrogen, -C 2 O-R 5, or R 5, provided that at least one R 4 or R 8 group is other than hydrogen; each R 5 is independently -C R 6, -C OR 6, -C -O-R 6, -C -(CH 2) n -C OR 6, -C -(CH 2) n -C N(R 7) 2, -C -(CH 2) n -CH(R 6)N(R 7) 2, -P (OR 6) 2; each R 6 is independently hydrogen, an optionally substituted C 1-6 aliphatic group or an optionally substituted 5-8 membered saturated, partially unsaturated, or fully unsaturated ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 7 is independently hydrogen, -C R 6, -C OR 6, -S 2 R 6, -OR 6, an optionally substituted C 1-6 aliphatic group or an optionally substituted 5-8 membered saturated, partially unsaturated, or fully unsaturated ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or: two R 6 on the same nitrogen atom taken together with the nitrogen atom bound thereto form a 4-7 membered saturated, partially unsaturated, or fully unsaturated ring having 1-3 heteroatoms in addition to the nitrogen atom, independently selected from nitrogen, oxygen, or sulfur; each n is 0-6; Q is an optionally substituted C 1-10 alkylidene chain wherein zero to four methylene units of Q are independently replaced by -O-, -N -, -S-, -S -, -S 2 -, or -C -; and R 8 is hydrogen or-C 2 O-R 5. R 1 is a C 1-6 aliphatic group, wherein R 1 is optionally substituted with up to 2 groups independently selected from -OR, -OR 4, or -C 1-3 haloalkyl; each R is independently hydrogen or a C 1-6 aliphatic; each R 2 is independently R, fluoro, or chloro; m is 0, 1, or 2; R 3 is hydrogen, C 1-3 aliphatic, fluoro, or chloro; each R 4 is independently hydrogen, -C 2 O-R 5, or R 5, provided that at least one R 4 or R 8 group is other than hydrogen; each R 5 is independently -C R 6, -C OR 6, -C -O-R 6, -C -(CH 2) n -C OR 6, -C -(CH 2) n -C N(R 7) 2, -C -(CH 2) n -CH(R 6)N(R 7) 2, -P (OR 6) 2; each R 6 is independently hydrogen, an optionally substituted C 1-6 aliphatic group or an optionally substituted 5-8 membered saturated, partially unsaturated, or fully unsaturated ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R 7 is independently hydrogen, -C R 6, -C OR 6, -S 2 R 6, -OR 6, an optionally substituted C 1-6 aliphatic group or an optionally substituted 5-8 membered saturated, partially unsaturated, or fully unsaturated ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or: two R 6 on the same nitrogen atom taken together with the nitrogen atom bound thereto form a 4-7 membered saturated, partially unsaturated, or fully unsaturated ring having 1-3 heteroatoms in addition to the nitrogen atom, independently selected from nitrogen, oxygen, or sulfur; two R 6 on the same nitrogen atom taken together with the nitrogen atom bound thereto form a 4-7 membered saturated, partially unsaturated, or fully unsaturated ring having 1-3 heteroatoms in addition to the nitrogen atom, independently selected from nitrogen, oxygen, or sulfur; each n is 0-6; Q is an optionally substituted C 1-10 alkylidene chain wherein zero to four methylene units of Q are independently replaced by -O-, -N -, -S-, -S -, -S 2 -, or -C -; and R 8 is hydrogen or-C 2 O-R 5.