A compound of the formula: wherein: W is wherein: R A is -H or -F; and R B is -H, -OH, or -F, wherein if R A is -F, then R B is -H or -F; A is C-R" or N, wherein: R" is -H, or -OH; R' is -H; X is: halo, t -butyl, CF 3, CF 2 H or cyano; wherein R 4 and R 5 are each independently alkyl (C≤8), or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 6 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CH 2 F, -CO 2 H, -CO2-alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 4 and R 5 are each -CF 3, then R 6 is -OH; wherein n is 1 or 2 and X 1 is -H; or wherein: A' is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 7 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); Y is: t -butyl; wherein R 8 and R 9 are each independently alkyl (C≤8) or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 10 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 8 and R 9 are each -CF 3, then R 10 is -OH; wherein n" is 1 or 2 and Y 1 is -H; or wherein: A" is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 11 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); L is hydrogen; and Z is hydrogen or hydroxy and is attached to either carbon atom 2 or 6; provided that if W is then X and Y are not both each t- butyl; and further provided that if W is A is C-OH, Z is hydrogen, and X is bromo or iodo, then Y is not t -butyl; or a pharmaceutically acceptable salt or tautomer thereof. W is wherein: R A is -H or -F; and R B is -H, -OH, or -F, wherein if R A is -F, then R B is -H or -F; R A is -H or -F; and R B is -H, -OH, or -F, wherein if R A is -F, then R B is -H or -F; A is C-R" or N, wherein: R" is -H, or -OH; R" is -H, or -OH; R' is -H; X is: halo, t -butyl, CF 3, CF 2 H or cyano; wherein R 4 and R 5 are each independently alkyl (C≤8), or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 6 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CH 2 F, -CO 2 H, -CO2-alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 4 and R 5 are each -CF 3, then R 6 is -OH; wherein n is 1 or 2 and X 1 is -H; or wherein: A' is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 7 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); R 4 and R 5 are each independently alkyl (C≤8), or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 6 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CH 2 F, -CO 2 H, -CO2-alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 4 and R 5 are each -CF 3, then R 6 is -OH; wherein n is 1 or 2 and X 1 is -H; or wherein: A' is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 7 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); Y is: t -butyl; wherein R 8 and R 9 are each independently alkyl (C≤8) or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 10 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 8 and R 9 are each -CF 3, then R 10 is -OH; wherein n" is 1 or 2 and Y 1 is -H; or wherein: A" is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 11 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); R 8 and R 9 are each independently alkyl (C≤8) or substituted alkyl (C≤8), wherein one or more hydrogen atom has been independently replaced by -OH, -F, -Cl, -Br, -I, -NH 2, -NO 2, -CO 2 H,-CO 2 CH 3, -CN, -SH, -OCH 3, -OCH 2 CH 3, -C CH 3,-N(CH 3) 2, -C NH 2, -OC CH 3, or -S 2 NH 2; R 10 is -OH, -CN, -NH 2, -CF 3, -CF 2 H, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CH 2 OH, or alkoxy (C≤8), provided that where R 8 and R 9 are each -CF 3, then R 10 is -OH; wherein n" is 1 or 2 and Y 1 is -H; or wherein: A" is a covalent bond, thereby forming a cyclopropane ring, alkanediyl (C≤6) or alkoxydiyl (C≤8); and R 11 is -OH, -CN, -NH 2, -CO 2 H, -CO 2 -alkyl (C≤8), -C(=O)NH 2, -CF 3, -CF 2 H, or alkoxy (C≤8); L is hydrogen; and Z is hydrogen or hydroxy and is attached to either carbon atom 2 or 6;