A cryotherapy device comprising: at least one inflow channel; at least one element (49, 69a, 69b, 69c, 69d, 69e), located at said distal end of said cryotherapy device and defining a channel between said inflow channel and a body lumen, wherein said at least one inflow channel is configured to provide said pressurized expandable cryo-fluid from a source of said pressurized expandable cryo-fluid to a distal end of said cryotherapy device, and that said at least one element is configured for selectively directing the pressurized expandable cryo-fluid from said distal end of said cryotherapy device directly onto tissue at a targeted area in the body lumen and configured for expansion of the pressurized expandable cryo-fluid when exiting from said cryotherapy device towards said targeted area in the body lumen; at least one outflow channel; wherein the comprises: at least one sensor that gathers data regarding internal pressure in said body lumen; control means for controlling evacuation of fluid from said body lumen through said at least one outflow channel, wherein said control means is configured to receive data from said at least one sensor and to control evacuation of fluid from said body lumen through said at least one outflow channel according to said received data, wherein said body lumen comprises a bladder, a cervix, a prostate and/or uterus, and wherein said cryotherapy device that comprises said at least one inflow channel and said at least one outflow channel, has an overall diameter between 0.8-9 mm. at least one inflow channel; at least one element (49, 69a, 69b, 69c, 69d, 69e), located at said distal end of said cryotherapy device and defining a channel between said inflow channel and a body lumen, wherein said at least one inflow channel is configured to provide said pressurized expandable cryo-fluid from a source of said pressurized expandable cryo-fluid to a distal end of said cryotherapy device, and that said at least one element is configured for selectively directing the pressurized expandable cryo-fluid from said distal end of said cryotherapy device directly onto tissue at a targeted area in the body lumen and configured for expansion of the pressurized expandable cryo-fluid when exiting from said cryotherapy device towards said targeted area in the body lumen; at least one outflow channel; wherein the comprises: at least one sensor that gathers data regarding internal pressure in said body lumen; control means for controlling evacuation of fluid from said body lumen through said at least one outflow channel, wherein said control means is configured to receive data from said at least one sensor and to control evacuation of fluid from said body lumen through said at least one outflow channel according to said received data, wherein said body lumen comprises a bladder, a cervix, a prostate and/or uterus, and wherein said cryotherapy device that comprises said at least one inflow channel and said at least one outflow channel, has an overall diameter between 0.8-9 mm. at least one sensor that gathers data regarding internal pressure in said body lumen; control means for controlling evacuation of fluid from said body lumen through said at least one outflow channel, wherein said control means is configured to receive data from said at least one sensor and to control evacuation of fluid from said body lumen through said at least one outflow channel according to said received data, wherein said body lumen comprises a bladder, a cervix, a prostate and/or uterus, and wherein said cryotherapy device that comprises said at least one inflow channel and said at least one outflow channel, has an overall diameter between 0.8-9 mm.