A cryotherapeutic system (100, 200), comprising: a high-pressure line (106, 206) configured to be removably connected to a supply lumen of a cryo-catheter; a low-pressure line (108, 210) configured to be removably connected to an exhaust lumen of the cryo-catheter; and a recompression unit (110, 400, 500, 600, 700) operably connected to the high-pressure line (106, 206) and the low-pressure line (108, 210), the recompression unit (110, 400, 500, 600, 700) configured to increase the pressure of and at least partially condense refrigerant moving from the low-pressure line (108, 210) to the high-pressure line (106, 206), wherein the high-pressure line (106, 206), the low-pressure line (108, 210), and the recompression unit are configured to define a portion of a closed loop when the high-pressure line (106, 206) is operably connected to the supply lumen and the low-pressure line (108, 210) is operably connected to the exhaust lumen, and wherein: the high-pressure line (106, 206), the low-pressure line (108, 210), and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir (138, 220) configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line (106, 206), disconnecting the exhaust lumen from the low-pressure line (108, 210), or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel (111, 212) configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant. a high-pressure line (106, 206) configured to be removably connected to a supply lumen of a cryo-catheter; a low-pressure line (108, 210) configured to be removably connected to an exhaust lumen of the cryo-catheter; and a recompression unit (110, 400, 500, 600, 700) operably connected to the high-pressure line (106, 206) and the low-pressure line (108, 210), the recompression unit (110, 400, 500, 600, 700) configured to increase the pressure of and at least partially condense refrigerant moving from the low-pressure line (108, 210) to the high-pressure line (106, 206), wherein the high-pressure line (106, 206), the low-pressure line (108, 210), and the recompression unit are configured to define a portion of a closed loop when the high-pressure line (106, 206) is operably connected to the supply lumen and the low-pressure line (108, 210) is operably connected to the exhaust lumen, and wherein: the high-pressure line (106, 206), the low-pressure line (108, 210), and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir (138, 220) configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line (106, 206), disconnecting the exhaust lumen from the low-pressure line (108, 210), or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel (111, 212) configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant. the high-pressure line (106, 206), the low-pressure line (108, 210), and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir (138, 220) configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line (106, 206), disconnecting the exhaust lumen from the low-pressure line (108, 210), or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel (111, 212) configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant.