A straddled vehicle comprising: an engine having a cylinder unit; and a body frame for supporting the engine; the body frame including: a head tube having at least part thereof located forward and upward of the engine; a right frame extending rearward and downward from the head tube; and a left frame disposed leftward of the right frame and extending rearward and downward from the head tube; the right frame including a right main frame (6R, 82R) disposed above the engine in a side view of the vehicle; the left frame including a left main frame (6L, 82L) disposed above the engine in the side view of the vehicle; the cylinder unit including: a cylinder member having a cylinder bore centering on a cylinder axis extending upward and forward at an angle of 45 degrees or larger to a horizontal line in the side view of the vehicle; a cylinder head connected to an upper part of the cylinder member, and having ports formed therein for communicating with the cylinder bore; a head cover connected to an upper part of the cylinder head, and forming a valve operating chamber with the cylinder head; a valve operating device disposed in the valve operating chamber for opening and closing the ports; and a variable valve mechanism having an actuator for changing opening and closing conditions of the valve operating device; the actuator having an actuator body disposed outside the valve operating chamber, wherein the body frame is not disposed forward of a front wall (35F, 41F, 45F, F1) of each of the cylinder member, the cylinder head, and the head cover, and does not overlap the each front wall (35F, 41F, 45F, F1) in a front view of the vehicle; the actuator body is attached to the head cover; the actuator body has a center thereof located rearward of the cylinder axis in the side view of the vehicle; and characterised in that, the cylinder unit is inclined so that the actuator body overlap neither the right main frame (6R, 82R) nor the left main frame (6L, 82L) in the side view of the vehicle. an engine having a cylinder unit; and a body frame for supporting the engine; the body frame including: a head tube having at least part thereof located forward and upward of the engine; a right frame extending rearward and downward from the head tube; and a left frame disposed leftward of the right frame and extending rearward and downward from the head tube; a head tube having at least part thereof located forward and upward of the engine; a right frame extending rearward and downward from the head tube; and a left frame disposed leftward of the right frame and extending rearward and downward from the head tube; the right frame including a right main frame (6R, 82R) disposed above the engine in a side view of the vehicle; the left frame including a left main frame (6L, 82L) disposed above the engine in the side view of the vehicle; the cylinder unit including: a cylinder member having a cylinder bore centering on a cylinder axis extending upward and forward at an angle of 45 degrees or larger to a horizontal line in the side view of the vehicle; a cylinder head connected to an upper part of the cylinder member, and having ports formed therein for communicating with the cylinder bore; a head cover connected to an upper part of the cylinder head, and forming a valve operating chamber with the cylinder head; a valve operating device disposed in the valve operating chamber for opening and closing the ports; and a variable valve mechanism having an actuator for changing opening and closing conditions of the valve operating device; the actuator having an actuator body disposed outside the valve operating chamber, wherein the body frame is not disposed forward of a front wall (35F, 41F, 45F, F1) of each of the cylinder member, the cylinder head, and the head cover, and does not overlap the each front wall (35F, 41F, 45F, F1) in a front view of the vehicle; the actuator body is attached to the head cover; the actuator body has a center thereof located rearward of the cylinder axis in the side view of the vehicle; and characterised in that, the cylinder unit is inclined so that the actuator body overlap neither the right main frame (6R, 82R) nor the left main frame (6L, 82L) in the side view of the vehicle. a cylinder member having a cylinder bore centering on a cylinder axis extending upward and forward at an angle of 45 degrees or larger to a horizontal line in the side view of the vehicle; a cylinder head connected to an upper part of the cylinder member, and having ports formed therein for communicating with the cylinder bore; a head cover connected to an upper part of the cylinder head, and forming a valve operating chamber with the cylinder head; a valve operating device disposed in the valve operating chamber for opening and closing the ports; and a variable valve mechanism having an actuator for changing opening and closing conditions of the valve operating device; the actuator having an actuator body disposed outside the valve operating chamber, wherein the body frame is not disposed forward of a front wall (35F, 41F, 45F, F1) of each of the cylinder member, the cylinder head, and the head cover, and does not overlap the each front wall (35F, 41F, 45F, F1) in a front view of the vehicle; the actuator body is attached to the head cover; the actuator body has a center thereof located rearward of the cylinder axis in the side view of the vehicle; and characterised in that, the cylinder unit is inclined so that the actuator body overlap neither the right main frame (6R, 82R) nor the left main frame (6L, 82L) in the side view of the vehicle.