Method for configuring a system for withdrawing body fluid, which system is usable for withdrawing body fluid from a body part via a withdrawal site located on the surface of said body part, said method comprising the steps of A) measuring at least one variable dependent on the location and state of the withdrawal site by using a sensor, wherein at least one of the following variables is measured: temperature, electrical resistance, electrical conductivity, electrical current strength, electrical voltage, position or inclination of the system upon contact with the withdrawal site, pressure, acceleration, and optical variables; B) selecting a setting, wherein i) said setting is selected dependent on the value of the measured at least one variable and wherein said setting influences the withdrawal of body fluid and ii) by said selection of the setting the system for withdrawing body fluid is automatically and optimally adapted to the withdrawal conditions before the skin is punctured, wherein at least one of the following settings is selected as a function of the value of the measured at least one variable: - blocking or releasing of a puncturing device, - setting a puncture depth of a puncturing device selected for creating the opening in the body, - setting a geometric shape of a press-on area of the system for withdrawing body fluid, - setting the cross section of an opening in a press-on area of the system for withdrawing body fluid, through which opening a puncturing device can penetrate into the surface of the body part, - selecting one of at least two press-on areas included in the system for withdrawing body fluid, - selecting one of at least two puncturing devices contained in the system for withdrawing body fluid, - setting the duration of the withdrawal procedure, and - displaying or setting evaluation parameters which are used by a system for analyzing body fluid. A) measuring at least one variable dependent on the location and state of the withdrawal site by using a sensor, wherein at least one of the following variables is measured: temperature, electrical resistance, electrical conductivity, electrical current strength, electrical voltage, position or inclination of the system upon contact with the withdrawal site, pressure, acceleration, and optical variables; B) selecting a setting, wherein i) said setting is selected dependent on the value of the measured at least one variable and wherein said setting influences the withdrawal of body fluid and ii) by said selection of the setting the system for withdrawing body fluid is automatically and optimally adapted to the withdrawal conditions before the skin is punctured, i) said setting is selected dependent on the value of the measured at least one variable and wherein said setting influences the withdrawal of body fluid and ii) by said selection of the setting the system for withdrawing body fluid is automatically and optimally adapted to the withdrawal conditions before the skin is punctured, - blocking or releasing of a puncturing device, - setting a puncture depth of a puncturing device selected for creating the opening in the body, - setting a geometric shape of a press-on area of the system for withdrawing body fluid, - setting the cross section of an opening in a press-on area of the system for withdrawing body fluid, through which opening a puncturing device can penetrate into the surface of the body part, - selecting one of at least two press-on areas included in the system for withdrawing body fluid, - selecting one of at least two puncturing devices contained in the system for withdrawing body fluid, - setting the duration of the withdrawal procedure, and - displaying or setting evaluation parameters which are used by a system for analyzing body fluid.