mhurhangee/ep-ind-claims huggingface dataset:
A process for synthesising a compound of formula V wherein: n is 0, 1 or 2; and R is H or or a physiologically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof, the process comprising the steps of: a) deprotecting a N -benzyl protected histidine of formula 11 to form N -benzyl histidine of formula 12 b) converting compound 12 to -3-(1-benzyl-1 H -imidazol-4-yl)-2-(dimethylamino)propanoic acid of formula 13 c) converting compound 13 to (2 S)- N,N,N -2-trimethylethanaminium-3-(1-benzyl-1 H -imidazol-4-yl)propanoic acid of formula 14 d) brominating the imidazole ring of the compound of formula 14 to form 5-bromohercynine lactone; and e) converting the 5-bromohercynine lactone of step (d) to (β-amino-β-carboxyethyl)ergothioneine sulfide of formula 15 wherein the process optionally further includes any one of steps (f) to (h): f) converting the compound of formula 15 to a sulfoxide of formula II or g) converting the compound of formula 15 to a sulfone of formula III or h) converting the compound of formula 15 to ergothioneine of formula IV n is 0, 1 or 2; and R is H or a) deprotecting a N -benzyl protected histidine of formula 11 to form N -benzyl histidine of formula 12 b) converting compound 12 to -3-(1-benzyl-1 H -imidazol-4-yl)-2-(dimethylamino)propanoic acid of formula 13 c) converting compound 13 to (2 S)- N,N,N -2-trimethylethanaminium-3-(1-benzyl-1 H -imidazol-4-yl)propanoic acid of formula 14 d) brominating the imidazole ring of the compound of formula 14 to form 5-bromohercynine lactone; and e) converting the 5-bromohercynine lactone of step (d) to (β-amino-β-carboxyethyl)ergothioneine sulfide of formula 15 f) converting the compound of formula 15 to a sulfoxide of formula II or g) converting the compound of formula 15 to a sulfone of formula III or h) converting the compound of formula 15 to ergothioneine of formula IV
A wireless detonator arrangement which includes an initiator, a first housing in which is mounted a power supply, contacts connected to the power supply, a second housing which contains an explosive material, contacts at a first end of the second housing, contacts at a second end of the second housing, and conductors which extend from the contacts to the contacts, and a third housing which is engageable with the first end of the second housing, a signal processing assembly mounted inside the second housing, the signal processing assembly including a receiver and a processor for processing wireless signals received by the receiver, and contacts connected to the signal processing assembly, the first housing being engageable with the second end of the second housing thereby to connect the power supply to the signal processing assembly via a conductive path comprising the contacts (46, 48), the conductors and the contacts (52, 54),, and wherein the signal processing assembly, responsive to a fire command signal, causes ignition of the initiator.
An information processing apparatus for setting parameters for functional units to be used in a control system, the control system comprising a master device and one or more slave devices (1, 3) connected to the master device via a network, each slave device (1, 3) comprising one or more functional units configured to transmit and receive a signal to and from a control target, the information processing apparatus being characterized by: a calculation unit configured to calculate the parameters for the functional units included in each slave device in accordance with a mode selected from a plurality of available modes according to a user selection, wherein the parameters are set to values prestored in a device profile prepared for each functional unit and include parameters unique to the corresponding functional unit, particularly an input response delay time, an input conversion delay time, and an output response delay time; and a setting unit configured to set parameters calculated by the calculation unit in the control system, the plurality of modes including a first mode in which a timing to obtain a status value from the control target and a timing to update an output value for the control target are synchronized between all the functional units included in the slave device (1, 3), and a second mode in which the timing to obtain a status value from the control target and the timing to update an output value for the control target are synchronized between specific functional units from the functional units included in the slave device (1, 3). a calculation unit configured to calculate the parameters for the functional units included in each slave device in accordance with a mode selected from a plurality of available modes according to a user selection, wherein the parameters are set to values prestored in a device profile prepared for each functional unit and include parameters unique to the corresponding functional unit, particularly an input response delay time, an input conversion delay time, and an output response delay time; and a setting unit configured to set parameters calculated by the calculation unit in the control system, the plurality of modes including a first mode in which a timing to obtain a status value from the control target and a timing to update an output value for the control target are synchronized between all the functional units included in the slave device (1, 3), and a second mode in which the timing to obtain a status value from the control target and the timing to update an output value for the control target are synchronized between specific functional units from the functional units included in the slave device (1, 3). a first mode in which a timing to obtain a status value from the control target and a timing to update an output value for the control target are synchronized between all the functional units included in the slave device (1, 3), and a second mode in which the timing to obtain a status value from the control target and the timing to update an output value for the control target are synchronized between specific functional units from the functional units included in the slave device (1, 3).
3D printing process for the production of tissues and organs with vascular structures organs by means of (a) a droplet printer for photorealistic high-resolution prints and (b) a device for applying electromagnetic waves (202, 203) comprising the steps of: - providing at least a bio-ink and a capillary ink comprising cells and crosslinking molecules in the droplet printer - applying at least one droplet of the bioink and the capillary ink to a reaction plane - bringing the electromagnetic waves into contact with the crosslinking molecules in these droplets on the reaction plane - and activating the cross-linking molecules by means of undirected or directed movements of the electromagnetic waves in the droplets, whereby cross-linked structures are formed and vascular structures are thus obtained, characterised in that the capillary inks only crosslink or react in a layer-forming manner in the edge region of the drop and wherein uncrosslinked or unbound components are removed. (a) a droplet printer for photorealistic high-resolution prints and (b) a device for applying electromagnetic waves (202, 203) comprising the steps of: - providing at least a bio-ink and a capillary ink comprising cells and crosslinking molecules in the droplet printer - applying at least one droplet of the bioink and the capillary ink to a reaction plane - bringing the electromagnetic waves into contact with the crosslinking molecules in these droplets on the reaction plane - and activating the cross-linking molecules by means of undirected or directed movements of the electromagnetic waves in the droplets, whereby cross-linked structures are formed and vascular structures are thus obtained, - providing at least a bio-ink and a capillary ink comprising cells and crosslinking molecules in the droplet printer - applying at least one droplet of the bioink and the capillary ink to a reaction plane - bringing the electromagnetic waves into contact with the crosslinking molecules in these droplets on the reaction plane - and activating the cross-linking molecules by means of undirected or directed movements of the electromagnetic waves in the droplets, whereby cross-linked structures are formed and vascular structures are thus obtained,
A dust collecting apparatus to separate dust from introduced air comprising: a dust collecting receptacle which is opened at a lower portion thereof; a dust discharge cover mounted at the lower portion of the dust collecting receptacle so as to allow opening and closing thereof; and a packing member coupled to a lower side of the dust collecting receptacle to seal the dust collecting receptacle and the dust discharge cover, characterized in that the dust collecting receptacle is formed at an end thereof with a coupling groove; the packing member comprises a first sealing portion which extends from an end of the dust collecting receptacle to an inner portion of the dust collecting receptacle; and a coupling portion coupled to the coupling groove; the first sealing portion is mounted so as to cover a portion of an inner surface of the dust discharge cover from an upper surface of an edge portion of the dust discharge cover; and the packing member presses the dust discharge cover in a direction of opening the dust discharge cover. a dust collecting receptacle which is opened at a lower portion thereof; a dust discharge cover mounted at the lower portion of the dust collecting receptacle so as to allow opening and closing thereof; and a packing member coupled to a lower side of the dust collecting receptacle to seal the dust collecting receptacle and the dust discharge cover, characterized in that the dust collecting receptacle is formed at an end thereof with a coupling groove; the packing member comprises a first sealing portion which extends from an end of the dust collecting receptacle to an inner portion of the dust collecting receptacle; and a coupling portion coupled to the coupling groove; a first sealing portion which extends from an end of the dust collecting receptacle to an inner portion of the dust collecting receptacle; and a coupling portion coupled to the coupling groove; the first sealing portion is mounted so as to cover a portion of an inner surface of the dust discharge cover from an upper surface of an edge portion of the dust discharge cover; and the packing member presses the dust discharge cover in a direction of opening the dust discharge cover.
A casting core assembly, comprising: a casting core having an outer surface; a bumper disposed on the outer surface, the bumper extending outward from the outer surface, characterized by the bumper comprising a receptacle; and a metal apparatus partially disposed in the receptacle of the bumper, a portion of the metal apparatus extending outward from the bumper, wherein the metal apparatus is a sphere, and wherein the sphere is integrated into a bumper assembly of the casting core, the bumper assembly comprising the bumper and the sphere. a casting core having an outer surface; a bumper disposed on the outer surface, the bumper extending outward from the outer surface, characterized by the bumper comprising a receptacle; and a metal apparatus partially disposed in the receptacle of the bumper, a portion of the metal apparatus extending outward from the bumper, wherein the metal apparatus is a sphere, and wherein the sphere is integrated into a bumper assembly of the casting core, the bumper assembly comprising the bumper and the sphere.
Nedisertib or a physiologically acceptable salt or solvate thereof, for use in medicine in the treatment of disorders associated with an undesired genotype of a patient in need of the treatment, the disorder being a metabolic dysfunction or cancer, comprising genome editing in a eukaryotic target cell or in a eukaryotic target organism, wherein processes for cloning human beings, processes for modifying the germ line genetic identity of human beings, and uses of human embryos for industrial and commercial purposes are excluded.
A snare drum comprising: a hollow cylindrical shell; a batter head mounted on one end of the hollow cylindrical shell; a snare side head (13, 33, 43, 53) mounted on the other end of the hollow cylindrical shell, the snare side head (13, 33, 43, 53) having a plurality of through-holes (13c, 33c, 43c, 43d, 53c); and a snare wire adapted to vibrate on the snare side head (13, 33, 43, 53); characterized in that the through-holes (13c, 33c, 43c, 43d, 53c) are provided only on an area of the snare side head (13, 33, 43, 53) which does not face the snare wire. a hollow cylindrical shell; a batter head mounted on one end of the hollow cylindrical shell; a snare side head (13, 33, 43, 53) mounted on the other end of the hollow cylindrical shell, the snare side head (13, 33, 43, 53) having a plurality of through-holes (13c, 33c, 43c, 43d, 53c); and a snare wire adapted to vibrate on the snare side head (13, 33, 43, 53); characterized in that the through-holes (13c, 33c, 43c, 43d, 53c) are provided only on an area of the snare side head (13, 33, 43, 53) which does not face the snare wire.
An electrode current collector comprising a metal foil, wherein a coating layer is formed on one or both surfaces of the metal foil, the coating layer comprises a conductive assistant, a fluorine-based polymer and a resin, the resin is other than a fluorine-based polymer, a silicon-based polymer, a fluorine compound, a silicon compound, and a content of the fluorine-based polymer with respect to a total amount of the fluorine-based polymer and the resin is 0.45 % to 20 % by mass.
Polyurea compound preparable via reaction of a polyisocyanate based on isophorone diisocyanate and having isocyanurate and allophanate groups with an aminosilane of general formula R 1 a (R 1 O) (3-a) Si (CH 2) n NHCHR 2 CH 2 COOR 3 where the radicals R 1 independently of one another are selected from C 1 -C 20 -alkyl or C 6 -C 20 -aryl, a is an integer between 0 and 2, n is an integer between 1 and 4, R 2 is selected from H, C 1 -C 20 -alkyl, C 6 -C 12 -aryl and -COOR 3, and R 3 in each case is C 1 -C 20 -alkyl. a is an integer between 0 and 2, n is an integer between 1 and 4, R 2 is selected from H, C 1 -C 20 -alkyl, C 6 -C 12 -aryl and -COOR 3, and R 3 in each case is C 1 -C 20 -alkyl.
Watch case comprising a middle and a control device for a clockwork mechanism comprising a pushbutton that is arranged through a suitable opening of said middle and is intended to act on a control lever of the clockwork mechanism in response to an action of a user, said control device comprising an intermediate rocker that is intended to be interposed between said pushbutton and the control lever of the clockwork mechanism, said intermediate rocker being arranged so as to have a rotary movement about an axis X1 and comprising an actuation finger that is intended to act on the control lever of the clockwork mechanism in response to the action of the user, said intermediate rocker having a contact surface which is arranged facing said pushbutton and on which the latter exerts a pressure in response to the action of the user, said contact surface being located between said axis of rotation X1 and said actuation finger, said control device comprising an external control member that is arranged to act on said pushbutton in response to the action of the user, said external control member comprising an external control lever that is mounted so as to be able to pivot on said middle about an axis of rotation X2, and having a grip surface that is intended to receive the pressure from the user, said grip surface and said axis of rotation X2 being respectively located on either side of an actuation surface of said external control lever arranged facing said pushbutton so as to act thereon in response to the action of the user, said grip surface being arranged so as to effect a lever arm the purpose of which is to increase the force applied to said pushbutton compared to the force exerted by the user on said external control lever, said control device comprising at least one return spring arranged between said middle and said external control lever. said intermediate rocker having a contact surface which is arranged facing said pushbutton and on which the latter exerts a pressure in response to the action of the user, said contact surface being located between said axis of rotation X1 and said actuation finger, said control device comprising an external control member that is arranged to act on said pushbutton in response to the action of the user, said external control member comprising an external control lever that is mounted so as to be able to pivot on said middle about an axis of rotation X2, and having a grip surface that is intended to receive the pressure from the user, said grip surface and said axis of rotation X2 being respectively located on either side of an actuation surface of said external control lever arranged facing said pushbutton so as to act thereon in response to the action of the user, said grip surface being arranged so as to effect a lever arm the purpose of which is to increase the force applied to said pushbutton compared to the force exerted by the user on said external control lever, said control device comprising at least one return spring arranged between said middle and said external control lever.
A superhydrophobic coating, comprising: a hydrophobic thermoset resin powder; and a plurality of superhydrophobic particles, wherein each superhydrophobic particle comprises a hydrophilic porous core provided with a hydrophobic coating and has a three dimensional, nanostructured surface topology, defining a plurality of pores, the hydrophobic coating conforming to the surface of the superhydrophobic particle so as to preserve the nanostructured surface topology, wherein at least a portion of the superhydrophobic particles are embedded within the cured thermal set resin so as to be surrounded by and mechanically bonded to the resin, and wherein the pore volume of the superhydrophobic particle is less than 50% filled by the resin such that the three dimensional surface topology of the superhydrophobic particles is preserved. a hydrophobic thermoset resin powder; and a plurality of superhydrophobic particles, wherein each superhydrophobic particle comprises a hydrophilic porous core provided with a hydrophobic coating and has a three dimensional, nanostructured surface topology, defining a plurality of pores, the hydrophobic coating conforming to the surface of the superhydrophobic particle so as to preserve the nanostructured surface topology, wherein at least a portion of the superhydrophobic particles are embedded within the cured thermal set resin so as to be surrounded by and mechanically bonded to the resin, and wherein the pore volume of the superhydrophobic particle is less than 50% filled by the resin such that the three dimensional surface topology of the superhydrophobic particles is preserved. wherein each superhydrophobic particle comprises a hydrophilic porous core provided with a hydrophobic coating and has a three dimensional, nanostructured surface topology, defining a plurality of pores, the hydrophobic coating conforming to the surface of the superhydrophobic particle so as to preserve the nanostructured surface topology, wherein at least a portion of the superhydrophobic particles are embedded within the cured thermal set resin so as to be surrounded by and mechanically bonded to the resin, and wherein the pore volume of the superhydrophobic particle is less than 50% filled by the resin such that the three dimensional surface topology of the superhydrophobic particles is preserved.
Portable lighting apparatus, comprising - a lighting device; - a column device which carries the lighting device and extends in a longitudinal direction; - a stand device which carries the column device; and comprising - a ballast for providing electrical power for the lighting device; wherein - the ballast is arranged on the column device in the longitudinal direction below the column device; - the ballast is held by a holding device (16, 17) on the column device; - the ballast comprises a suspension device; - the holding device (16, 17) can be connected to the suspension device in order to hold the ballast; - the suspension device comprises a handle device for carrying the ballast; and wherein - the holding device (16, 17) is formed to hold the handle device. - a lighting device; - a column device which carries the lighting device and extends in a longitudinal direction; - a stand device which carries the column device; and comprising - a ballast for providing electrical power for the lighting device; - the ballast is arranged on the column device in the longitudinal direction below the column device; - the ballast is held by a holding device (16, 17) on the column device; - the ballast comprises a suspension device; - the holding device (16, 17) can be connected to the suspension device in order to hold the ballast; - the suspension device comprises a handle device for carrying the ballast; and wherein - the holding device (16, 17) is formed to hold the handle device.
An optical measurement apparatus (1, 201, 301) comprising: a main body base; an optical base movably combined with the main body base; and a measurement optical system fixed to the optical base, characterized in that the optical measurement apparatus (1, 201, 301) further comprises an optical base moving mechanism which moves the optical base relative to the main body base between an internal measurement position defined such that a measurement object position of the measurement optical system coincides with an internal measurement object position within the main body base and an external measurement position defined such that the measurement object position of the measurement optical system coincides with an external measurement object position outside the main body base. a main body base; an optical base movably combined with the main body base; and a measurement optical system fixed to the optical base, characterized in that the optical measurement apparatus (1, 201, 301) further comprises an optical base moving mechanism which moves the optical base relative to the main body base between an internal measurement position defined such that a measurement object position of the measurement optical system coincides with an internal measurement object position within the main body base and an external measurement position defined such that the measurement object position of the measurement optical system coincides with an external measurement object position outside the main body base.
A tool, in particular a screwdriver, comprising a housing and a handle, a working part connected to the housing and serving to open or close a screw connection and a coupling comprising an adjustment device, which coupling will decouple the working part from the housing if a labour value that can be set by means of the adjustment device, for example a tightening torque of the screw connection, is reached, and/or which coupling will signalize if the labour value adjustable by means of the adjustment device is obtained, characterized in that the adjustment device comprises an adjustment screw with a clamping system.