A system for assessing fluid responsiveness, the system comprising: at least one processor; an infusion pump in communication with the at least one processor; and a plurality of physiological monitors (40, 42, 44, 46) operable to receive physiological signals (48, 50) from an associated patient; wherein the at least one processor is programmed to: receive, from the infusion pump administering a fluid challenge to the associated patient, a timing signal corresponding to an infusion of fluids by the infusion pump during administration of the fluid challenge to the associated patient; synchronize physiological signals acquired from the associated patient during the fluid challenge with the timing signal of the infusion pump so as to indicate the amount of fluid provided to the associated patient in correlation with the corresponding physiological signal at a given time; calculate one or more dynamic indices and/or features from the synchronized physiological signals and calculate one or more dynamic indices and/ or features from baseline physiological signals acquired from the patient prior to administration of the fluid challenge; and determine a fluid responsiveness probability value of the patient based on the one or more dynamic indices and/or features calculated from the synchronized physiological signals and based on the one or more dynamic indices and/or features calculated from the baseline physiological signals. at least one processor; an infusion pump in communication with the at least one processor; and a plurality of physiological monitors (40, 42, 44, 46) operable to receive physiological signals (48, 50) from an associated patient; wherein the at least one processor is programmed to: receive, from the infusion pump administering a fluid challenge to the associated patient, a timing signal corresponding to an infusion of fluids by the infusion pump during administration of the fluid challenge to the associated patient; synchronize physiological signals acquired from the associated patient during the fluid challenge with the timing signal of the infusion pump so as to indicate the amount of fluid provided to the associated patient in correlation with the corresponding physiological signal at a given time; calculate one or more dynamic indices and/or features from the synchronized physiological signals and calculate one or more dynamic indices and/ or features from baseline physiological signals acquired from the patient prior to administration of the fluid challenge; and determine a fluid responsiveness probability value of the patient based on the one or more dynamic indices and/or features calculated from the synchronized physiological signals and based on the one or more dynamic indices and/or features calculated from the baseline physiological signals. receive, from the infusion pump administering a fluid challenge to the associated patient, a timing signal corresponding to an infusion of fluids by the infusion pump during administration of the fluid challenge to the associated patient; synchronize physiological signals acquired from the associated patient during the fluid challenge with the timing signal of the infusion pump so as to indicate the amount of fluid provided to the associated patient in correlation with the corresponding physiological signal at a given time; calculate one or more dynamic indices and/or features from the synchronized physiological signals and calculate one or more dynamic indices and/ or features from baseline physiological signals acquired from the patient prior to administration of the fluid challenge; and determine a fluid responsiveness probability value of the patient based on the one or more dynamic indices and/or features calculated from the synchronized physiological signals and based on the one or more dynamic indices and/or features calculated from the baseline physiological signals.