A compound having the Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halo, (C 1 -C 4)alkyl, or hydroxyl; X is S, SO, SO 2, or -SONH; R 2 is (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, or halo(C 1 -C 4)alkyl; R 3 is cyano or nitro; R 4 is hydrogen, halo, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, or hydroxyl; R 5 is halo, halo(C 1 -C 4)alkyl, or cyano; R 6 is halo, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkyl, or cyano; R 7 is halo, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkyl, halo(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylOR a, -(C 1 -C 4)alkylC R a, -(C 1 -C 4)alkylC OR a, -C NR a R b, -(C 1 -C4)alkylC NR a R b, -C R a, -C OR a, -NR a R b, -(C 1 -C 4)alkylNR a R b, -C NR a SO 3 H, - NR a C R b, -NR a C OR b, -NR a C OR b, -NR c C N a R b, -NR c C NR a R b, - NR c S 2 NR a R b, -C R a, -S 2 R a, -S R a, -C OR a, -C NR a R b, -NR a C R b, -SR a, phenyl, 4- to 6-membered heterocyclyl, and 5- to 7-membered heteroaryl, wherein each of said phenyl, 4- to 6-membered heterocyclyl, and 5- to 7-membered heteroaryl are optionally and independently substituted with 1 to 3 groups selected from R 8 R 8 is selected from halo, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, nitro, oxo, cyano, -(C 1 -C 4)alkylOR d, -(C 1 -C 4)alkylC R d, -(C 1 -C4)alkylC OR d, -C NR d R e, -(C 1 -C 4)alkylC NR d R e, -C R d, -C OR d, -NR d R e, - (C 1 -C 4)alkylNR d R e, -C NR d SO 3 H, -NR d C R e, -NR d C OR e, -NR d C OR e, - NR f C N d R e, -NR f C NR d R e, -NR f S 2 NR d R e, -C R d, -S 2 R d, -S R d, -C OR d, - C NR d R e, -NR d C R e, and -SR d; R a, R b, R c, R d, R e, and R f are each independently hydrogen or (C 1 -C 4)alkyl; and q and r are each independently 0 or 1. R 1 is hydrogen, halo, (C 1 -C 4)alkyl, or hydroxyl; X is S, SO, SO 2, or -SONH; R 2 is (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, or halo(C 1 -C 4)alkyl; R 3 is cyano or nitro; R 4 is hydrogen, halo, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, or hydroxyl; R 5 is halo, halo(C 1 -C 4)alkyl, or cyano; R 6 is halo, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkyl, or cyano; R 7 is halo, (C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkyl, halo(C 1 -C 4)alkoxy, -(C 1 -C 4)alkylOR a, -(C 1 -C 4)alkylC R a, -(C 1 -C 4)alkylC OR a, -C NR a R b, -(C 1 -C4)alkylC NR a R b, -C R a, -C OR a, -NR a R b, -(C 1 -C 4)alkylNR a R b, -C NR a SO 3 H, - NR a C R b, -NR a C OR b, -NR a C OR b, -NR c C N a R b, -NR c C NR a R b, - NR c S 2 NR a R b, -C R a, -S 2 R a, -S R a, -C OR a, -C NR a R b, -NR a C R b, -SR a, phenyl, 4- to 6-membered heterocyclyl, and 5- to 7-membered heteroaryl, wherein each of said phenyl, 4- to 6-membered heterocyclyl, and 5- to 7-membered heteroaryl are optionally and independently substituted with 1 to 3 groups selected from R 8 R 8 is selected from halo, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, nitro, oxo, cyano, -(C 1 -C 4)alkylOR d, -(C 1 -C 4)alkylC R d, -(C 1 -C4)alkylC OR d, -C NR d R e, -(C 1 -C 4)alkylC NR d R e, -C R d, -C OR d, -NR d R e, - (C 1 -C 4)alkylNR d R e, -C NR d SO 3 H, -NR d C R e, -NR d C OR e, -NR d C OR e, - NR f C N d R e, -NR f C NR d R e, -NR f S 2 NR d R e, -C R d, -S 2 R d, -S R d, -C OR d, - C NR d R e, -NR d C R e, and -SR d; R a, R b, R c, R d, R e, and R f are each independently hydrogen or (C 1 -C 4)alkyl; and q and r are each independently 0 or 1.