A compound having the Formula: or any pharmaceutically acceptable salts, solvates, hydrates, N-oxides, tautomers or rotamers thereof, wherein is independently selected from the group consisting of B is furanyl or oxazolyl, each of which is optionally substituted with R 1a and R 1b which are independently selected from the group consisting of halogen, CN, C 1-4 alkyl, C 1-4 alkoxy and C 1-4 haloalkyl; R 3 is a member selected from the group consisting of H and D; R 4 is a member selected from the group consisting of H, C 1-8 alkyl, OH, - NR a R b, -C 1-4 alkoxy, and Y; wherein the C 1-8 alkyl is optionally substituted with halogen, -CN, - CO 2 R a, -CONR a R b, -C R a, OC NR a R b, -NR a C R b, -NR a C a R c, - NR a C NR a R b, -NR a R b, -OR a, -S 2 NR a R b, -NR a S 2 R b and Y, wherein Y is a 4 to 8 membered cycloheteroalkyl group or a 3 to 8 membered cycloalkyl group or a 5- or 6-membered aryl or heteroaryl group any of which is optionally substituted with from 1 to four substituents selected from halogen, oxo, -CN, -C 1-6 alkyl, -C 1-6 alkoxy, -C 1-6 hydroxyalkyl, -C 1-6 haloalkyl, O- C 1-6 haloalkyl, -C 1-4 alkyl-O-C 1-4 alkyl, -C 1-6 alkyl-NR a R b, -C 1-6 alkyl-CO 2 H, -C 1-6 alkyl-CO 2 R a, -C 1-6 alkyl-CONR a R b, -C 1-6 alkyl-C R a, - C 1-6 alkyl-OC NR a R b, -C 1-6 alkyl-NR a C R b, -C 1-6 alkyl-NR a C 2 R c, -C 1-6 alkyl-NR a C NR a R b, -C 1-6 alkyl-OR a, -C 1-6 alkyl-S 2 NR a R b, -C 1-6 alkyl-NR a S 2 R b, - CO 2 R a, -CONR a R b, -C R a, -OC NR a R b, -NR a C R b, -NR a C 2 R c, - NR a C NR a R b, -NR a R b, -OR a, -S 2 NR a R b, -NR a S 2 R b,-CH 2 CO 2 R a; each R a and R b is independently selected from hydrogen, C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 haloalkyl, and R c is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 haloalkyl; and wherein the 4 to 8 membered cycloheteroalkyl group and the 3 to 8 membered cycloalkyl group may additionally be optionally substituted with oxo; R 5a and R 5b are each members independently selected from the group consisting of H, halogen, C 1-4 alkyl, -C 1-4 haloalkyl, O-C 1-4 haloalkyl, C 1-4 alkoxy, CO 2 H and CN; and R 7 is a member selected from the group consisting of methyl, ethyl and C 1-2 haloalkyl. B is furanyl or oxazolyl, each of which is optionally substituted with R 1a and R 1b which are independently selected from the group consisting of halogen, CN, C 1-4 alkyl, C 1-4 alkoxy and C 1-4 haloalkyl; R 3 is a member selected from the group consisting of H and D; R 4 is a member selected from the group consisting of H, C 1-8 alkyl, OH, - NR a R b, -C 1-4 alkoxy, and Y; wherein the C 1-8 alkyl is optionally substituted with halogen, -CN, - CO 2 R a, -CONR a R b, -C R a, OC NR a R b, -NR a C R b, -NR a C a R c, - NR a C NR a R b, -NR a R b, -OR a, -S 2 NR a R b, -NR a S 2 R b and Y, wherein Y is a 4 to 8 membered cycloheteroalkyl group or a 3 to 8 membered cycloalkyl group or a 5- or 6-membered aryl or heteroaryl group any of which is optionally substituted with from 1 to four substituents selected from halogen, oxo, -CN, -C 1-6 alkyl, -C 1-6 alkoxy, -C 1-6 hydroxyalkyl, -C 1-6 haloalkyl, O- C 1-6 haloalkyl, -C 1-4 alkyl-O-C 1-4 alkyl, -C 1-6 alkyl-NR a R b, -C 1-6 alkyl-CO 2 H, -C 1-6 alkyl-CO 2 R a, -C 1-6 alkyl-CONR a R b, -C 1-6 alkyl-C R a, - C 1-6 alkyl-OC NR a R b, -C 1-6 alkyl-NR a C R b, -C 1-6 alkyl-NR a C 2 R c, -C 1-6 alkyl-NR a C NR a R b, -C 1-6 alkyl-OR a, -C 1-6 alkyl-S 2 NR a R b, -C 1-6 alkyl-NR a S 2 R b, - CO 2 R a, -CONR a R b, -C R a, -OC NR a R b, -NR a C R b, -NR a C 2 R c, - NR a C NR a R b, -NR a R b, -OR a, -S 2 NR a R b, -NR a S 2 R b,-CH 2 CO 2 R a; each R a and R b is independently selected from hydrogen, C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 haloalkyl, and R c is selected from C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 haloalkyl; and wherein the 4 to 8 membered cycloheteroalkyl group and the 3 to 8 membered cycloalkyl group may additionally be optionally substituted with oxo; R 5a and R 5b are each members independently selected from the group consisting of H, halogen, C 1-4 alkyl, -C 1-4 haloalkyl, O-C 1-4 haloalkyl, C 1-4 alkoxy, CO 2 H and CN; and R 7 is a member selected from the group consisting of methyl, ethyl and C 1-2 haloalkyl.