mhurhangee/ep-ind-claims huggingface dataset:
A recombinant microorganism comprising: (a) a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis, wherein said one or more enzymes is encoded by a gpd1, gpd2, gpp1, gpp2 or fps1 polynucleotide; (b) a heterologous pyruvate formate lyase for conversion of pyruvate to acetyl-CoA and formate and heterologous and/or native acetaldehyde dehydrogenase, alcohol dehydrogenase, or a bifunctional acetaldehyde/alcohol dehydrogenase for conversion of acetyl-CoA to ethanol; (c) a deletion of one or more enzymes encoded by a fdh1 polynucleotide and/or a fdh2 polynucleotide; and (d) one or more heterologous polynucleotides which encodes a heterologous saccharolytic enzyme, wherein the heterologous saccharolytic enzyme is a glucoamylase. (a) a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis, wherein said one or more enzymes is encoded by a gpd1, gpd2, gpp1, gpp2 or fps1 polynucleotide; (b) a heterologous pyruvate formate lyase for conversion of pyruvate to acetyl-CoA and formate and heterologous and/or native acetaldehyde dehydrogenase, alcohol dehydrogenase, or a bifunctional acetaldehyde/alcohol dehydrogenase for conversion of acetyl-CoA to ethanol; (c) a deletion of one or more enzymes encoded by a fdh1 polynucleotide and/or a fdh2 polynucleotide; and (d) one or more heterologous polynucleotides which encodes a heterologous saccharolytic enzyme, wherein the heterologous saccharolytic enzyme is a glucoamylase.
Measuring arrangement for measuring a molten tube or a blow-molding product (16, 116, 216), the measuring arrangement comprising: - a molten tube put out by a blow-molding extruder through a ring gap along an extrusion axis or a blow-molding product (16, 116, 216) extruded along an extrusion axis, - a THz measuring device including at least one THz sensor, said THz sensor comprising optics for focusing a THz transmission beam onto a focus, - a controller means, adapted to receive measuring signals from the THz measuring device and to determine at least one wall thickness (wd) of a front wall of the molten tube or the blow-molding product (16, 116, 216), the front wall lying in a divergent beam area of the THz transmission beam behind the focus or in a convergent beam area before the focus, where the front wall has a set distance to the focus that lies in an area above a Rayleigh length up to a pre-determined multiple of the Rayleigh length, and the focal point lies before the extrusion axis and/or the axis of symmetry of the molten tube or the blow-molding product (16, 116, 216). the measuring arrangement comprising: - a molten tube put out by a blow-molding extruder through a ring gap along an extrusion axis or a blow-molding product (16, 116, 216) extruded along an extrusion axis, - a THz measuring device including at least one THz sensor, said THz sensor comprising optics for focusing a THz transmission beam onto a focus, - a controller means, adapted to receive measuring signals from the THz measuring device and to determine at least one wall thickness (wd) of a front wall of the molten tube or the blow-molding product (16, 116, 216), - a molten tube put out by a blow-molding extruder through a ring gap along an extrusion axis or a blow-molding product (16, 116, 216) extruded along an extrusion axis, - a THz measuring device including at least one THz sensor, said THz sensor comprising optics for focusing a THz transmission beam onto a focus, - a controller means, adapted to receive measuring signals from the THz measuring device and to determine at least one wall thickness (wd) of a front wall of the molten tube or the blow-molding product (16, 116, 216), the front wall lying in a divergent beam area of the THz transmission beam behind the focus or in a convergent beam area before the focus, where the front wall has a set distance to the focus that lies in an area above a Rayleigh length up to a pre-determined multiple of the Rayleigh length, and the focal point lies before the extrusion axis and/or the axis of symmetry of the molten tube or the blow-molding product (16, 116, 216).
A system for rapidly starting an engine of a multi-engine aircraft, the system comprising: a first engine and a second engine, the first and second engines (16A, 16B) coupled to a rotor of the aircraft, a first energy source comprising at least one supercapacitor; and a starter-generator configured to be coupled to the first engine during regular starting of the first engine at a regular rate, and coupled to the second engine during rapid starting of the second engine using the first energy source at a rapid rate higher than the regular rate, wherein the first energy source is in charging engagement with the first or second engine (16A, 16B) via the starter-generator, characterised in that either (i) the at least one supercapacitor is configured to operate at different output settings under normal and rapid-start conditions and to deliver energy to the starter-generator at the regular rate during regular starting of the first engine, or (ii) the system further comprises a second energy source configured to deliver energy to the starter-generator at the regular rate during regular starting of the first engine. a first engine and a second engine, the first and second engines (16A, 16B) coupled to a rotor of the aircraft, a first energy source comprising at least one supercapacitor; and a starter-generator configured to be coupled to the first engine during regular starting of the first engine at a regular rate, and coupled to the second engine during rapid starting of the second engine using the first energy source at a rapid rate higher than the regular rate, wherein the first energy source is in charging engagement with the first or second engine (16A, 16B) via the starter-generator, characterised in that either (i) the at least one supercapacitor is configured to operate at different output settings under normal and rapid-start conditions and to deliver energy to the starter-generator at the regular rate during regular starting of the first engine, or (ii) the system further comprises a second energy source configured to deliver energy to the starter-generator at the regular rate during regular starting of the first engine.
An apparatus for producing microdroplets using microchannels in a crossed form, said apparatus comprising a microchannel board and a holder for retaining the microchannel board, wherein the microchannel board has: a microdroplet-outlet port formed at the center thereof, microdroplet-forming parts on a first to a Mth (M is an integer of 1 or more) circular or polygonal peripheries from inside to outside, said microdroplet-forming parts being connected through microchannels to the microdroplet-outlet port and a plurality of said microdroplet-forming parts being disposed on each of said M circular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for a first liquid disposed on a first circular or polygonal inlet periphery with the microdroplet-outlet port at the center, inlet ports for 2 nd up to a Nth liquid (N is an integer of 2 or more, M≤N-1) sequentially disposed on circular or polygonal inlet peripheries further outside of the first inlet periphery, and microchannels for feeding the first to the Nth liquids to the above plurality of microdroplet-forming parts from the first to the Nth inlet ports, wherein the holder for retaining the microchannel board has a multitube structure, with the microdroplet-outlet port as the central axis, the multitube structure having N circular or polygonal circular channels (I, II) for providing an even flow rate of the above first to the Nth liquids to the inlet ports (1, 2) for each liquid of the microchannel board. a microdroplet-outlet port formed at the center thereof, microdroplet-forming parts on a first to a Mth (M is an integer of 1 or more) circular or polygonal peripheries from inside to outside, said microdroplet-forming parts being connected through microchannels to the microdroplet-outlet port and a plurality of said microdroplet-forming parts being disposed on each of said M circular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for a first liquid disposed on a first circular or polygonal inlet periphery with the microdroplet-outlet port at the center, inlet ports for 2 nd up to a Nth liquid (N is an integer of 2 or more, M≤N-1) sequentially disposed on circular or polygonal inlet peripheries further outside of the first inlet periphery, and microchannels for feeding the first to the Nth liquids to the above plurality of microdroplet-forming parts from the first to the Nth inlet ports,
A conjugate delivery system for in vivo delivering an RNA interference polynucleotide to a liver cell comprising: N-A and wherein, P is an amphipathic membrane active polyamine; L 2 is a physiologically labile linkage; M 1 is a charge neutral masking agent containing a targeting moiety, M 2 is a charge neutral masking agent containing a steric stabilizer, N is an RNA interference polynucleotide, A is a galactose trimer or a hydrophobic group having at least 20 carbon atoms, y is an integer greater than or equal to 1 and z is an integer greater than or equal to 0 wherein the value of y and z together is greater than 50% of the number of amines of the polyamine P; the positive charge of polyamine P is neutralized and the membrane activity of polyamine P is reversibly inhibited by attachment of M 1 and M 2 through the physiologically labile linkage L 2 and cleavage of L2 in response to a decrease in pH restores membrane activity of the polyamine P; N and A are not, directly or indirectly, covalently linked to P, L 2, M 1 or M 2. P is an amphipathic membrane active polyamine; L 2 is a physiologically labile linkage; M 1 is a charge neutral masking agent containing a targeting moiety, M 2 is a charge neutral masking agent containing a steric stabilizer, N is an RNA interference polynucleotide, A is a galactose trimer or a hydrophobic group having at least 20 carbon atoms, y is an integer greater than or equal to 1 and z is an integer greater than or equal to 0 wherein the value of y and z together is greater than 50% of the number of amines of the polyamine P; the positive charge of polyamine P is neutralized and the membrane activity of polyamine P is reversibly inhibited by attachment of M 1 and M 2 through the physiologically labile linkage L 2 and cleavage of L2 in response to a decrease in pH restores membrane activity of the polyamine P; N and A are not, directly or indirectly, covalently linked to P, L 2, M 1 or M 2.
An aircraft propulsion system intended for being integrated into the rear of an aircraft fuselage, the propulsion system comprising, from upstream to downstream in the direction of a gas flow in the propulsion system, at least two gas generators (102a, 102b) supplying a power turbine having two counter-rotating turbine rotors (104a, 104b) for driving two fans (112a, 112b) disposed downstream of the gas generators (102a, 102b), and separate air inlets (106a, 106b) for supplying each gas generator (102a, 102b), characterised in that it comprises an electrical drive device configured to rotate at least one of the turbine rotors (104a, 104b) and comprising at least one electrical generator (142a, 142b) configured to transform part of the energy of the flow coming from the gas generators (102a, 102b) into electrical power and an electric motor supplied by said electrical generator (142a, 142b) and capable of rotating at least one of the turbine rotors (104a, 104b), said electrical generator (142a, 142b) being installed on one of said gas generators (102a, 102b), and in that said turbine rotor is capable of being rotated simultaneously by a flow coming from said gas generators (102a, 102b) and by the electrical drive device.
Under ballast mat, comprising a base structure, on which spring elements made from an elastomeric material are arranged, the cross-section of which tapers from the base structure to its free end, characterised in that the cross-section of the latter is oval, wherein a first group of spring elements (6, 10) is provided for which the longer extension of the cross-section of the respective spring element (6, 10) extends along a first axis and at least one second group of spring elements (8, 12) is provided for which the longer extension of the cross-section extends along a second axis, wherein the first axis and the second axis are arranged at right angles to one another and wherein spring elements (6, 10) of the first group and spring elements (8, 12) of the second groups are arranged alternately along both axes (14, 16).
A thioether having the formula: B-(A-R 3) z wherein: (i) B denotes a z-valent residue of a polyfunctionalizing agent; (ii) A denotes a structure having the formula: -[-S- p -(R 1 X) q -R 2 -] n - in which: (a) each R, which may be the same or different, denotes a C 2-10 n-alkylene group; (b) each R 1, which may be the same or different, denotes a C 1-10 n-alkylene group; (c) each R 2, which may be the same or different, denotes a C 2-10 n-alkylene group; (d) each X denotes O; (e) p has a value of from 1 to 5; (f) q has a value of 0 to 5; (g) n has a value of at least 2; and (h) R and R 1 are different from each other; (iii) each R 3, which may be the same or different, comprises -SH; -OH, alkyl, alkenyl, -NCO, or a hydrolyzable functional group; and (iv) z is an integer from 3 to 6. (i) B denotes a z-valent residue of a polyfunctionalizing agent; (ii) A denotes a structure having the formula: -[-S- p -(R 1 X) q -R 2 -] n - in which: (a) each R, which may be the same or different, denotes a C 2-10 n-alkylene group; (b) each R 1, which may be the same or different, denotes a C 1-10 n-alkylene group; (c) each R 2, which may be the same or different, denotes a C 2-10 n-alkylene group; (d) each X denotes O; (e) p has a value of from 1 to 5; (f) q has a value of 0 to 5; (g) n has a value of at least 2; and (h) R and R 1 are different from each other; (a) each R, which may be the same or different, denotes a C 2-10 n-alkylene group; (b) each R 1, which may be the same or different, denotes a C 1-10 n-alkylene group; (c) each R 2, which may be the same or different, denotes a C 2-10 n-alkylene group; (d) each X denotes O; (e) p has a value of from 1 to 5; (f) q has a value of 0 to 5; (g) n has a value of at least 2; and (h) R and R 1 are different from each other; (iii) each R 3, which may be the same or different, comprises -SH; -OH, alkyl, alkenyl, -NCO, or a hydrolyzable functional group; and (iv) z is an integer from 3 to 6.
Use of a concentration device for monitoring drinking water quality by image analysis of protozoan contaminants after filtration, wherein said device comprises: a filter configured to filter particles of a predefined size in the volume of the fluid wherein the concentration device comprises an ultrasonic transducer that is configured to clean the filter; and wherein the concentration device comprises a housing having a cavity, which cavity is separated into a first volume and a second volume by the filter; wherein the housing has an inlet being in fluid communication with the first volume and the housing has an outlet being in fluid communication with the second volume and that the particles are concentrated in the first volume; and wherein the ultrasonic transducer has a driving surface arranged in the second volume; wherein the housing has a concentrate outlet being in fluid communication with the first volume and that the concentration device comprises means for pumping concentrate away from the first volume to an analysis device or a collection container for further analysis through the concentrate outlet; wherein said filter is plate-shaped. a filter configured to filter particles of a predefined size in the volume of the fluid wherein the concentration device comprises an ultrasonic transducer that is configured to clean the filter; and wherein the concentration device comprises a housing having a cavity, which cavity is separated into a first volume and a second volume by the filter;
Apparatus for inspecting a sample, provided with a charged particle microscope (7, 8) having a column for producing a focused beam of charged particles to observe or modify the sample, and an optical microscope (2, 3, 4) to observe a region of interest on the sample as is observed by the charged particle beam or vice versa, the apparatus accommodated with a detection and processing unit is adapted and equipped for acquiring an image as generated with said charged particle and said optical microscope, the unit is further adapted for performing an image alignment procedure mutually correlating the image coordinate systems of said images, wherein the apparatus is adapted for using a detection of a change in the optical image as caused therein by the charged particle beam for correlating said images characterized in that the change in the optical image comprises a modification in a luminescent or fluorescent light from the sample or the generation of cathodoluminescence light by the charged particle beam falling on the sample.
Sulfur-crosslinkable rubber mixture, characterized in that it comprises at least the following constituents: - 5 to 95 phr of at least one styrene-butadiene rubber, which is functionalized with phthalocyanine groups and/or hydroxy groups and/or epoxy groups and/or silane sulfide groups, has a styrene content of 0 to 12 wt%, and has a glass transition temperature (Tg) in the unvulcanized state according to DSC of -75 to -120°C, - 5 to 95 phr of at least one further rubber, and - 20 to 300 phr of at least one silicic acid. - 5 to 95 phr of at least one styrene-butadiene rubber, which is functionalized with phthalocyanine groups and/or hydroxy groups and/or epoxy groups and/or silane sulfide groups, has a styrene content of 0 to 12 wt%, and has a glass transition temperature (Tg) in the unvulcanized state according to DSC of -75 to -120°C, - 5 to 95 phr of at least one further rubber, and - 20 to 300 phr of at least one silicic acid.
A compound of formula or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein R 1 is hydrogen, or R 1 is a C 4-7 heterocycle group, aryl, or a bicyclic heterocycle group, each of which is optionally substituted by one or more C 1-6 alkoxy; R 2 is C 1-6 alkyl, with the proviso that N-(2-amino-5-phenethylpyrimidine-4-yl)-N-pentylamine is excluded, for use in the treatment of a disorder in which the modulation of TLR 7 and/or the modulation of TLR8 is involved to treat viral infections. R 1 is hydrogen, or R 1 is a C 4-7 heterocycle group, aryl, or a bicyclic heterocycle group, each of which is optionally substituted by one or more C 1-6 alkoxy; R 2 is C 1-6 alkyl,
Method for programming a projectile during passage through a weapon barrel, a muzzle brake or the like by means of a programming unit, having the following steps: - the programming is carried out during passage by means of a waveguide which is operated below the cut-off frequency of the relevant waveguide mode (TE, TM), - a signal generator provides a signal at a constant frequency (f 1) which is operated below the lowest cut-off frequency of the waveguide, - an item of information required for the programming is modulated onto the carrier for the frequency (f 1) in a modulator and is imprinted on the projectile. - the programming is carried out during passage by means of a waveguide which is operated below the cut-off frequency of the relevant waveguide mode (TE, TM), - a signal generator provides a signal at a constant frequency (f 1) which is operated below the lowest cut-off frequency of the waveguide, - an item of information required for the programming is modulated onto the carrier for the frequency (f 1) in a modulator and is imprinted on the projectile.
Water-bearing household appliance with a pipe system (6, 7, 10) for process liquid and with a measurement device for determining the surface tension of the process liquid, wherein the measurement device has at least a nozzle and measurement means (47, 48) arranged at the nozzle, for determining at least a parameter of the process liquid, which depends on the surface tension, wherein the household appliance is adapted to rinse at least the nozzle for cleansing, and wherein the measurement device has a vat arrangement for capturing the process liquid, characterized in that the vat arrangement is pivotable or rotatable with a drive, and wherein the nozzle is arranged at the vat arrangement and is pivotable or rotatable with the vat arrangement.
A surgical device comprising: a handle assembly; a locking collar; and a set of replaceable bits that load along an axis into said handle assembly; wherein said locking collar is fully removable from said handle assembly, said locking collar loads axially to a first position, and said locking collar rotates between said first position and a second position; wherein, in said second position, said locking collar is prevented from axial movement relative to said handle assembly and said replaceable bits are prevented from being received within, or removed from, said handle assembly; characterized in that, in said first position, said locking collar is free to be axially removed from said handle assembly and said replaceable bits are free to be loaded or unloaded from said handle assembly; and said locking collar is guided to said first position and between said first position and said second position by a groove in said handle assembly mating with a member carried by said locking collar. a handle assembly; a locking collar; and a set of replaceable bits that load along an axis into said handle assembly; wherein said locking collar is fully removable from said handle assembly, said locking collar loads axially to a first position, and said locking collar rotates between said first position and a second position; wherein, in said second position, said locking collar is prevented from axial movement relative to said handle assembly and said replaceable bits are prevented from being received within, or removed from, said handle assembly; characterized in that, in said first position, said locking collar is free to be axially removed from said handle assembly and said replaceable bits are free to be loaded or unloaded from said handle assembly; and said locking collar is guided to said first position and between said first position and said second position by a groove in said handle assembly mating with a member carried by said locking collar.
Sliding door module/pivotable sliding door module for a rail vehicle, comprising: - at least one door panel, - a carrier orientated along the sliding direction of the door panel, which in particular is fitted so that it can be moved horizontally in the direction transverse to its length, and - a linear guide with a profiled rail and at least one guiding carriage/guiding slide, wherein the profiled rail is fixed on the carrier or forms part thereof in the form of a profiled area, wherein the at least one guiding carriage/guiding slide is fitted onto the profiled rail and wherein with the help of the at least one guiding carriage/guiding slide the door panel is fitted so that it can slide, characterised in that the maximum static deflection of the carrier relative to its bearing points (7, 8, 12, 13) when the door panel is open in the range of a clear door width LW of 800 mm to 2300 mm amounts to at least y 1 = 0,007 ⋅ e LW 800 − 1 millimetres per kilogram of door panel weight. - at least one door panel, - a carrier orientated along the sliding direction of the door panel, which in particular is fitted so that it can be moved horizontally in the direction transverse to its length, and - a linear guide with a profiled rail and at least one guiding carriage/guiding slide, wherein the profiled rail is fixed on the carrier or forms part thereof in the form of a profiled area, wherein the at least one guiding carriage/guiding slide is fitted onto the profiled rail and wherein with the help of the at least one guiding carriage/guiding slide the door panel is fitted so that it can slide,