mhurhangee/ep-ind-claims huggingface dataset:
A method of production of substituted, optically active alcohols of formula IV in which Cyc stands for a mono- or polynuclear, saturated or unsaturated, carbocyclic or heterocyclic, optionally singly or multiply substituted ring, which has at least one free hydroxyl group, and R 1 and R 2 independently of one another stand for H or an optionally singly or multiply substituted alkyl residue; or of salts of this compound; in each case in stereoisomerically pure form or as a mixture of stereoisomers, wherein a) a ketone of formula I in which Cyc has the meanings stated above, is reacted in the presence of an aliphatic alcohol with a halogenating agent to a halogenated compound of formula II in which Cyc has the meanings stated above and Hal stands for a halogen atom; b) the resultant compound of formula II is reduced enzymatically using an enzyme, selected from alcohol dehydrogenases (E.C. 1.1.1.1), to the alcohol of formula III in which Cyc and Hal have the meanings stated above; and c) the resultant alcohol of formula III is reacted with an amine of formula HNR 1 R 2, in which R 1 and R 2 have the meanings stated above, to the compound of formula IV. Cyc stands for a mono- or polynuclear, saturated or unsaturated, carbocyclic or heterocyclic, optionally singly or multiply substituted ring, which has at least one free hydroxyl group, and R 1 and R 2 independently of one another stand for H or an optionally singly or multiply substituted alkyl residue; or of salts of this compound; in each case in stereoisomerically pure form or as a mixture of stereoisomers, a) a ketone of formula I in which Cyc has the meanings stated above, is reacted in the presence of an aliphatic alcohol with a halogenating agent to a halogenated compound of formula II in which Cyc has the meanings stated above and Hal stands for a halogen atom; b) the resultant compound of formula II is reduced enzymatically using an enzyme, selected from alcohol dehydrogenases (E.C. 1.1.1.1), to the alcohol of formula III in which Cyc and Hal have the meanings stated above; and c) the resultant alcohol of formula III is reacted with an amine of formula HNR 1 R 2, in which R 1 and R 2 have the meanings stated above, to the compound of formula IV.
A process for producing readily saccharifiable biomass comprising: a) providing lignocellulosic biomass with a moisture content of between 15% and 30% by weight; b) contacting the biomass of (a) with anhydrous ammonia gas to produce ammonia-treated biomass having a moisture content after ammonia treatment that is equal to or less than 15% by weight; and c) disrupting the ammonia-treated biomass of (b) by applying mechanical energy through a mechanical disruption means to produce a pretreated biomass which is readily saccharifiable; whereby the pretreated biomass comprises an amorphous cellulose component and; wherein the percentage of the amorphous cellulose component in the pretreated biomass is higher as compared with the percentage of the amorphous cellulose component in a pretreated biomass not contacted with anhydrous ammonia gas and disrupted with the same level of mechanical energy as in (c). a) providing lignocellulosic biomass with a moisture content of between 15% and 30% by weight; b) contacting the biomass of (a) with anhydrous ammonia gas to produce ammonia-treated biomass having a moisture content after ammonia treatment that is equal to or less than 15% by weight; and c) disrupting the ammonia-treated biomass of (b) by applying mechanical energy through a mechanical disruption means to produce a pretreated biomass which is readily saccharifiable;
A method of guiding melanoma patient treatment with immunotherapy drugs, comprising: a) conducting mass spectrometry on a blood-based sample of the patient and obtaining mass spectrometry data; (b) obtaining integrated intensity values in the mass spectrometry data of a multitude of mass-spectral features; and (c) operating on the mass spectral data with a programmed computer implementing a classifier, wherein the classifier is obtained from filtered mini-classifiers combined using a regularized combination method comprising repeatedly conducting logistic regression with extreme dropout on the filtered mini-classifiers; wherein in the operating step the classifier compares the integrated intensity values with feature values of a reference set of class-labeled mass spectral data obtained from blood-based samples obtained from a multitude of other melanoma patients treated with an antibody drug blocking ligand activation of programmed cell death 1 (PD-1) with a classification algorithm and generates a class label for the sample, wherein the class label "Good" or the equivalent predicts the patient is likely to obtain similar benefit from a combination therapy comprising an antibody drug blocking ligand activation of PD-1 and an antibody drug targeting CTLA4 and is therefore guided to a monotherapy of an antibody drug blocking ligand activation of PD-1, whereas a class label of "Not Good" or the equivalent indicates the patient is likely to obtain greater benefit from the combination therapy as compared to the monotherapy of an antibody drug blocking ligand activation of programmed cell death 1 (PD-1) and is therefore guided to the combination therapy, wherein the mass spectral features include a multitude of features listed in Appendix A, Appendix B or Appendix C. a) conducting mass spectrometry on a blood-based sample of the patient and obtaining mass spectrometry data; (b) obtaining integrated intensity values in the mass spectrometry data of a multitude of mass-spectral features; and (c) operating on the mass spectral data with a programmed computer implementing a classifier, wherein the classifier is obtained from filtered mini-classifiers combined using a regularized combination method comprising repeatedly conducting logistic regression with extreme dropout on the filtered mini-classifiers;
A paper tube comprising, in the vicinity of at least one end, a tail thread wrapping groove having parallel edges along a circumferential direction perpendicular to the axis of the paper tube, the paper tube comprising a recession, the maximum width of which is greater than the width of the tail thread wrapping groove and the deepest part of which is deeper than the tail thread wrapping groove, over the tail thread wrapping groove or an extension of the tail thread wrapping groove, wherein the recession has a groove shape such that at least one side is greater than the width of the tail thread wrapping groove, and intersects the circumferential direction perpendicular to the axis of the paper tube, wherein the groove-shaped recession is provided orthogonally to the tail thread wrapping groove or the extension of the tail thread wrapping groove, and characterized in that the groove-shaped recession reaches an end of the paper tube. wherein the recession has a groove shape such that at least one side is greater than the width of the tail thread wrapping groove, and intersects the circumferential direction perpendicular to the axis of the paper tube, wherein the groove-shaped recession is provided orthogonally to the tail thread wrapping groove or the extension of the tail thread wrapping groove, and characterized in that the groove-shaped recession reaches an end of the paper tube.
A knocking sensor comprising: a sensor body including, a metal shell including a tubular portion which is formed in a cylindrical shape, and a flange portion which extends from one end portion of the tubular portion toward a radially outward side, an annular piezoelectric element in which the tubular portion is passed through a through hole thereof, an annular weight in which the tubular portion is passed through a through hole thereof and which is placed so as to sandwich the piezoelectric element with the flange portion, a flange portion-side electrode plate which is placed between the piezoelectric element and the flange portion, a weight-side electrode plate which is placed between the piezoelectric element and said annular weight, a flange portion-side insulating plate which is placed between the flange portion and the flange portion-side electrode plate and which electrically insulates the flange portion from the flange portion-side electrode plate, and a weight-side insulating plate which is placed between said annular weight and the weight-side electrode plate and which electrically insulates said annular weight from the weight-side electrode plate; and a resin molded body which is made of a resin and which covers the sensor body, and wherein the flange portion-side insulating plate and the weight-side insulating plate are made of a resin that does not contain ester bond, characterized in that the resin molded body is made of polyphenylene sulfide. a sensor body including, a metal shell including a tubular portion which is formed in a cylindrical shape, and a flange portion which extends from one end portion of the tubular portion toward a radially outward side, an annular piezoelectric element in which the tubular portion is passed through a through hole thereof, an annular weight in which the tubular portion is passed through a through hole thereof and which is placed so as to sandwich the piezoelectric element with the flange portion, a flange portion-side electrode plate which is placed between the piezoelectric element and the flange portion, a weight-side electrode plate which is placed between the piezoelectric element and said annular weight, a flange portion-side insulating plate which is placed between the flange portion and the flange portion-side electrode plate and which electrically insulates the flange portion from the flange portion-side electrode plate, and a weight-side insulating plate which is placed between said annular weight and the weight-side electrode plate and which electrically insulates said annular weight from the weight-side electrode plate; and a resin molded body which is made of a resin and which covers the sensor body, and
An assembly comprising an abnormality determination apparatus comprising an abnormality determination unit (203, 110, 401) configured to compare first obstacle information related to an obstacle detected by a first sensor with second obstacle information related to the obstacle detected by a second sensor existing in a location different from a location of the first sensor, the abnormality determination unit (203, 110, 401) configured to determine whether or not the first sensor or the second sensor is abnormal based on a result of the comparison, wherein the assembly comprising the first and second sensor, wherein the first sensor is an infrastructure sensor (200, 200A, 200B) adapted to be installed in a predetermined place to detect the obstacle, the second sensor is an onboard sensor adapted to be mounted on a vehicle, the onboard sensor being adapted to be mounted on each of a plurality of the vehicles, and the abnormality determination unit (203, 110, 401) compares the first obstacle information by the infrastructure sensor (200, 200A, 200B) with pieces of the second obstacle information by the respective onboard sensors mounted on at least two or more infrastructure cooperative vehicles selected from among a plurality of the vehicles, characterized in that the abnormality determination unit (203, 110, 401) determines that, if pieces of the second obstacle information by the respective onboard sensors mounted on the plurality of infrastructure cooperative vehicles do not match each other, the onboard sensor that outputs the second obstacle information different from the first obstacle information is abnormal; and determines that, if pieces of the second obstacle information by the respective onboard sensors match each other and if the first obstacle information does not match the second obstacle information, the infrastructure sensor (200, 200A, 200B) is abnormal. the first sensor is an infrastructure sensor (200, 200A, 200B) adapted to be installed in a predetermined place to detect the obstacle, the second sensor is an onboard sensor adapted to be mounted on a vehicle, the onboard sensor being adapted to be mounted on each of a plurality of the vehicles, and the abnormality determination unit (203, 110, 401) compares the first obstacle information by the infrastructure sensor (200, 200A, 200B) with pieces of the second obstacle information by the respective onboard sensors mounted on at least two or more infrastructure cooperative vehicles selected from among a plurality of the vehicles, characterized in that the abnormality determination unit (203, 110, 401) determines that, if pieces of the second obstacle information by the respective onboard sensors mounted on the plurality of infrastructure cooperative vehicles do not match each other, the onboard sensor that outputs the second obstacle information different from the first obstacle information is abnormal; and determines that, if pieces of the second obstacle information by the respective onboard sensors match each other and if the first obstacle information does not match the second obstacle information, the infrastructure sensor (200, 200A, 200B) is abnormal.
A rubber composition comprising a rubber component and a short fibrous resin having a ratio A/B of 1.5 or larger, wherein A is a length of a cross section perpendicular to a long axis direction in a long diameter direction thereof and B is a length of the cross section perpendicular to the long axis direction in a short diameter direction thereof, wherein the short fibrous resin is a complex resin comprising a hydrophilic resin and a coat layer coating the hydrophilic resin, wherein the coat layer is composed of a resin having an affinity with the rubber component, wherein the resin having an affinity with the rubber component is a low-melting point resin having a melting point lower than a maximum vulcanization temperature of the rubber composition, and the low-melting point resin is a polyolefin-based resin, and wherein A and B are measured according to the method as disclosed in the present description. a rubber component and a short fibrous resin having a ratio A/B of 1.5 or larger, wherein A is a length of a cross section perpendicular to a long axis direction in a long diameter direction thereof and B is a length of the cross section perpendicular to the long axis direction in a short diameter direction thereof, wherein the short fibrous resin is a complex resin comprising a hydrophilic resin and a coat layer coating the hydrophilic resin, wherein the coat layer is composed of a resin having an affinity with the rubber component, wherein the resin having an affinity with the rubber component is a low-melting point resin having a melting point lower than a maximum vulcanization temperature of the rubber composition, and the low-melting point resin is a polyolefin-based resin, and wherein A and B are measured according to the method as disclosed in the present description.
A sensor comprising: a molded body having an internal cavity comprising at least one terminal pin, at least one current collector connected to the at least one terminal pin, and a gas inlet port comprising a protrusion in the center of the body; a fitted table attached inside the internal cavity of the body with epoxy, the table comprising a hollow central leg, and a gas inlet port in alignment with the gas inlet port of the body, wherein the hollow central leg sits over and is configured to snap into the protrusion of the gas inlet port of the body; a vent membrane carried on the table wherein the vent membrane comprises a tab that hangs into the body; a counter electrode carried on the vent membrane; at least one first washer or pad carried on the counter electrode; a wick carried on the one first washer or pad; a reference electrode in communication with but separated from the counter electrode by the at least one first washer or pad; at least one second washer or pad; a sensing electrode in communication with but separated from the reference electrode by the at least one second washer or pad; and a cap on top of the sensing electrode, which cap attaches to the body and forms a seal to contain an enclosed electrolyte. a molded body having an internal cavity comprising at least one terminal pin, at least one current collector connected to the at least one terminal pin, and a gas inlet port comprising a protrusion in the center of the body; a fitted table attached inside the internal cavity of the body with epoxy, the table comprising a hollow central leg, and a gas inlet port in alignment with the gas inlet port of the body, wherein the hollow central leg sits over and is configured to snap into the protrusion of the gas inlet port of the body; a vent membrane carried on the table wherein the vent membrane comprises a tab that hangs into the body; a counter electrode carried on the vent membrane; at least one first washer or pad carried on the counter electrode; a wick carried on the one first washer or pad; a reference electrode in communication with but separated from the counter electrode by the at least one first washer or pad; at least one second washer or pad; a sensing electrode in communication with but separated from the reference electrode by the at least one second washer or pad; and a cap on top of the sensing electrode, which cap attaches to the body and forms a seal to contain an enclosed electrolyte.
Device for the enclosing of portions of excrement, bandaging materials, feminine hygiene articles or the like, each in a wrapping, with - a container or a lid for a container with at least one fill opening to receive at least one object being sealed, - a movement coordinator at least partly mounted in the container or the lid for a propelling of the object in at least one direction of movement, - at least one magazine (20, 30) for dispensing of wrapping material, wherein at least one surface region of the movement coordinator is arranged in the direction of movement toward the magazine (20, 30), - wherein either the fill opening looking in the direction of movement is arranged between at least two magazines (20, 30) each with at least one wrapping material or the at least one magazine (20, 30) stockpiles at least two wrapping materials, which can be separated from each other before reaching the fill opening or in the fill opening, looking in the direction of movement - and with a joining device, which is designed to communicate with the fill opening or which is arranged after the fill opening in the direction of movement, in order to join together the wrapping materials enclosing the object, characterized in that in a central region of the movement coordinator at least one ejector is arranged and the movement coordinator is at least partly open in a middle travel region, so that the ejector coming after the second magazine in the direction of movement reaches the wrapped material and ejects it, and preferably the wrapped material is designed to deflect the ejector against the force of a spring. - a container or a lid for a container with at least one fill opening to receive at least one object being sealed, - a movement coordinator at least partly mounted in the container or the lid for a propelling of the object in at least one direction of movement, - at least one magazine (20, 30) for dispensing of wrapping material, wherein at least one surface region of the movement coordinator is arranged in the direction of movement toward the magazine (20, 30), - wherein either the fill opening looking in the direction of movement is arranged between at least two magazines (20, 30) each with at least one wrapping material or the at least one magazine (20, 30) stockpiles at least two wrapping materials, which can be separated from each other before reaching the fill opening or in the fill opening, looking in the direction of movement - and with a joining device, which is designed to communicate with the fill opening or which is arranged after the fill opening in the direction of movement, in order to join together the wrapping materials enclosing the object, characterized in that in a central region of the movement coordinator at least one ejector is arranged and the movement coordinator is at least partly open in a middle travel region, so that the ejector coming after the second magazine in the direction of movement reaches the wrapped material and ejects it, and preferably the wrapped material is designed to deflect the ejector against the force of a spring.
A use of a liquid composition for forming a silica porous film, wherein the liquid composition is prepared by mixing a hydrolyzate of tetramethoxysilane or tetraethoxysilane as a silicon alkoxide with a silica sol in which fumed silica particles having primary particles having a mean particle diameter of 40 nm or less and secondary particles having a mean particle diameter of 20 nm to 400 nm, that is greater than the mean particle diameter of the primary particles, are dispersed in a liquid medium, wherein a mass ratio (A/B) of a SiO 2 content of the silica sol to a SiO 2 content in the hydrolyzate is in a range of 1/99 to 60/40, the liquid medium is any one of methanol, ethanol, isopropyl alcohol, ethylene glycol, propylene glycol monomethyl ether, and propylene glycol monomethyl ether acetate, and a SiO 2 concentration of the hydrolyzate is 1 % by mass to 20 % by mass. wherein a mass ratio (A/B) of a SiO 2 content of the silica sol to a SiO 2 content in the hydrolyzate is in a range of 1/99 to 60/40, the liquid medium is any one of methanol, ethanol, isopropyl alcohol, ethylene glycol, propylene glycol monomethyl ether, and propylene glycol monomethyl ether acetate, and a SiO 2 concentration of the hydrolyzate is 1 % by mass to 20 % by mass.
An intra-oral X-ray imaging arrangement comprising: a control system; a radiation source which is arranged e.g. in connection with a jointed arm construction; an electric image data receiver such as e.g. a sensor based on CMOS technology; and a wireless transmission link (33, 43; 36, 46) for transmitting at least image data detected by the electric image data receiver to a base station of the electric image data receiver, to an image processing device or to a corresponding other device capable of receiving image information, the transmitter and the receiver of which transmission link (33, 43; 36, 46) are arranged, on the one hand, in connection with the electric image data receiver, and on the other hand, at least in functional connection with said base station, characterised in that the arrangement further includes a wireless power transmission link (33, 43), which wireless power transmission link (33, 43) is arranged for the use of supplying the electric image data receiver with energy in connection with an imaging event. a control system; a radiation source which is arranged e.g. in connection with a jointed arm construction; an electric image data receiver such as e.g. a sensor based on CMOS technology; and a wireless transmission link (33, 43; 36, 46) for transmitting at least image data detected by the electric image data receiver to a base station of the electric image data receiver, to an image processing device or to a corresponding other device capable of receiving image information, the transmitter and the receiver of which transmission link (33, 43; 36, 46) are arranged, on the one hand, in connection with the electric image data receiver, and on the other hand, at least in functional connection with said base station, characterised in that the arrangement further includes a wireless power transmission link (33, 43), which wireless power transmission link (33, 43) is arranged for the use of supplying the electric image data receiver with energy in connection with an imaging event.