A process for the preparation of Compound: comprising the steps of: 1) reacting Compound 1 of the structure with Compound 2 of the formula wherein X is selected from Cl, Br, and I; Y is selected from OR 9, NHOC 1-3 alkyl, Cl, Br, and I; and R 9 is selected from C 1-3 alkyl, C 1-3 hydroxyalkyl, substituted phenyl and substituted benzyl; in a suitable solvent to yield Compounds 3a or 3b of the formula 2) converting Compound 3a or 3b to Compound 4 of the formula in the presence of an acid 3) subsequently reacting Compound 4 in an alcoholic solvent with a tri-alkyl orthoformate to yield Compound 5 of the formula wherein R 1 is C 1-6 alkyl; and R 3' is selected from C 1-6 alkyl, optionally substituted phenyl and benzyl; 4) which is ester hydrolyzed under basic condition or undergoes hydrogenolysis when R 3' is substituted benzyl to Compound 6 of the formula wherein R 1 and X are as defined above; 5) subsequently activating the carboxylic moiety of Compound 6 and reacting it with a chiral auxiliary to form Compound 6a of the formula wherein Xa is a chiral auxiliary and R 1 and X are as defined above; 6) then reacting Compound 6a with a base in the presence of a methyl donor such as alkyl halides in the presence of a chiral auxiliary to Compound 6b of the formula wherein R 1, X, and Xa are as defined above; 7) removing Xa to obtain Compound 7 of the formula wherein R 1 and X are as defined above; 8) subsequently reacting Compound 7 in the presence of a metal catalyst with Compound 8 of the structure to yield Compound 9 9) reducing the nitro group in Compound 9 to Compound 10 of the formula 10) cyclizing Compound 10 with a suitable coupling agent to yield Compound 11 11) unmasking the ketone functionality in the presence of an acid to yield Compound 12 12a) reducing Compound 12 with an ammonia equivalent in the presence of a reducing agent or 12b) an transaminase enzyme in the presence of an amine source, different recycling systems, and a co-factor to generate the amine stereogenic center present in Compound 13 13) which is then coupled with Compound 14 of the structure to yield Compound 1) reacting Compound 1 of the structure with Compound 2 of the formula wherein X is selected from Cl, Br, and I; Y is selected from OR 9, NHOC 1-3 alkyl, Cl, Br, and I; and R 9 is selected from C 1-3 alkyl, C 1-3 hydroxyalkyl, substituted phenyl and substituted benzyl; in a suitable solvent to yield Compounds 3a or 3b of the formula X is selected from Cl, Br, and I; Y is selected from OR 9, NHOC 1-3 alkyl, Cl, Br, and I; and R 9 is selected from C 1-3 alkyl, C 1-3 hydroxyalkyl, substituted phenyl and substituted benzyl; in a suitable solvent to yield Compounds 3a or 3b of the formula 2) converting Compound 3a or 3b to Compound 4 of the formula in the presence of an acid 3) subsequently reacting Compound 4 in an alcoholic solvent with a tri-alkyl orthoformate to yield Compound 5 of the formula wherein R 1 is C 1-6 alkyl; and R 3' is selected from C 1-6 alkyl, optionally substituted phenyl and benzyl; R 1 is C 1-6 alkyl; and R 3' is selected from C 1-6 alkyl, optionally substituted phenyl and benzyl; 4) which is ester hydrolyzed under basic condition or undergoes hydrogenolysis when R 3' is substituted benzyl to Compound 6 of the formula wherein R 1 and X are as defined above; 5) subsequently activating the carboxylic moiety of Compound 6 and reacting it with a chiral auxiliary to form Compound 6a of the formula wherein Xa is a chiral auxiliary and R 1 and X are as defined above; 6) then reacting Compound 6a with a base in the presence of a methyl donor such as alkyl halides in the presence of a chiral auxiliary to Compound 6b of the formula wherein R 1, X, and Xa are as defined above; 7) removing Xa to obtain Compound 7 of the formula wherein R 1 and X are as defined above; 8) subsequently reacting Compound 7 in the presence of a metal catalyst with Compound 8 of the structure to yield Compound 9 9) reducing the nitro group in Compound 9 to Compound 10 of the formula 10) cyclizing Compound 10 with a suitable coupling agent to yield Compound 11 11) unmasking the ketone functionality in the presence of an acid to yield Compound 12 12a) reducing Compound 12 with an ammonia equivalent in the presence of a reducing agent or 12b) an transaminase enzyme in the presence of an amine source, different recycling systems, and a co-factor to generate the amine stereogenic center present in Compound 13 13) which is then coupled with Compound 14 of the structure to yield Compound