mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising: (a) a plurality of intact, bacterially derived minicells, each minicell of the plurality encompassing regulatory RNA that is packaged in the minicell, and (b) a pharmaceutically acceptable carrier therefor, wherein (i) the regulatory RNA is selected from the group consisting of antisense ssRNA, ribozyme and decoy RNA, (ii) there is an absence from the minicells of a construct for in situ expression of the regulatory RNA, and (iii) the plurality comprises a therapeutically effective amount of the regulatory RNA. (a) a plurality of intact, bacterially derived minicells, each minicell of the plurality encompassing regulatory RNA that is packaged in the minicell, and (b) a pharmaceutically acceptable carrier therefor,
Oil separator, particularly for crankcase ventilation of an internal combustion engine, having a hollow member which extends axially in a longitudinal axis and through which a gas flow which is charged with oil can flow, wherein, in the hollow member, there is formed an oil separation member which is provided with an axial passage in the direction of the longitudinal axis is formed in a funnel-like manner such that the funnel-like shape is constructed so as to be open counter to the flow direction of the gas flow and which can be flowed against by the gas flow (12, wherein, in the region of the passage of the oil separation member, there is formed in the hollow member a redirection member which can be flowed against with the gas flow by the gas flow substantially from the direction of the longitudinal axis and by which the gas flow can be redirected radially outward against the inner side of the oil separation member and in that there is formed in the hollow member downstream of the oil separation member an opening funnel which forms a diffuser.
A connecting system for connecting two conduits in a body of water, the connecting system comprising a first tubular structure, which is coupled to a conduit and extends along a first longitudinal axis; a second tubular structure, which is coupled to another conduit, extends along a second longitudinal axis and comprises a tubular member, and a sleeve, which is telescopically coupled to the tubular member, and faces the first tubular structure; an actuating assembly comprising a bidirectional translating device to selectively displace the sleeve forward or backward so as to selectively couple or respectively uncouple an end portion of the sleeve and the first tubular structure, characterised in that: the bidirectional translating device comprises an actuator comprising a screw/nut mechanism for selectively sliding the sleeve in relation to the tubular member in two opposite directions and parallel to the second longitudinal axis.
Radically polymerisable dental material comprising 5 to 40 wt % of at least one polyfunctional radically polymerisable monomer, 2 to 15 wt % of at least one monofunctional radically polymerisable monomer, 0.1 to 3.0 wt.% of at least one photo initiator for the radical polymerisation and 10 to 85 wt % filler(s), characterised in that the dental material comprises a filler and the refractive index of the mixture of monomers and is from 1.50 to 1.70 and that the refractive index of the monomer mixture before curing corresponds to the refractive index of the filler or is greater by up to 0.013 and after curing is higher than the refractive index of the filler by at least 0.02, and the dental material, relative to the total quantity of filler, comprises - 0 to 15 wt % filler, the refractive index of which is 0.02 to at most 0.155 less than the refractive index of the mixture of monomers and, - 0 to 10 wt % filler that does not scatter visible light and does not affect the translucence and - at most 15.5 wt % filler that does not fall within any of these categories. 5 to 40 wt % of at least one polyfunctional radically polymerisable monomer, 2 to 15 wt % of at least one monofunctional radically polymerisable monomer, 0.1 to 3.0 wt.% of at least one photo initiator for the radical polymerisation and 10 to 85 wt % filler(s), - 0 to 15 wt % filler, the refractive index of which is 0.02 to at most 0.155 less than the refractive index of the mixture of monomers and, - 0 to 10 wt % filler that does not scatter visible light and does not affect the translucence and - at most 15.5 wt % filler that does not fall within any of these categories.
Biodegradable thermoplastic pellet comprising at least one caseinate and/or at least one casein, at least one plasticizer, and at least one biodegradable polyester.
A chemical compound suitable for use as a surface active agent, said compound comprising: - a carboxyl group comprising a first carbon atom bonded to a carbonyl oxygen and a hydroxyl oxygen; - a hydrocarbon chain bonded to the first carbon atom; and - an aromatic group bonded to the hydrocarbon chain at a secondary location - wherein a sulfonate group is bonded to the aromatic group - wherein a methyl-terminated polyethoxy group is bonded to the hydroxyl oxygen. - a carboxyl group comprising a first carbon atom bonded to a carbonyl oxygen and a hydroxyl oxygen; - a hydrocarbon chain bonded to the first carbon atom; and - an aromatic group bonded to the hydrocarbon chain at a secondary location - wherein a sulfonate group is bonded to the aromatic group - wherein a methyl-terminated polyethoxy group is bonded to the hydroxyl oxygen.
A plasmid vector comprising: (a) DNA encoding an infectious RNA molecule encoding an attenuated alphavirus; and (b) a eukaryotic RNA polymerase promoter; wherein the DNA encoding the infectious RNA molecule is operably linked to the RNA polymerase promoter. (a) DNA encoding an infectious RNA molecule encoding an attenuated alphavirus; and (b) a eukaryotic RNA polymerase promoter;
A double T shaped building element for a floor construction and/or roof construction in a building, which building element comprises an upper side, a lower side, at least one first lateral face, at least one first end face and two flange elements extending down from its lower side, wherein the building element comprises reinforcement iron that extend out from the at least one end face for casting into a load bearing element, characterized in that the at least one lateral face is formed with a longitudinal groove such that a longitudinal upper groove edge and a longitudinal lower groove edge are formed where the upper groove edge and the lower groove edge extend along the whole length of the side face, which upper groove edge has a toothed shape, and that the building element comprises at least one rapid coupling device with a sleeve element being cast embedded into the building element and which end in the at least one end face such that a telescoping element, which is arranged in the sleeve element, mav be pulled out of the sleeve element.
An isolated nucleic acid molecule comprising or consisting of the nucleic acid sequence of SEQ ID NO:1, or comprising or consisting of a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression of a gene in rod photoreceptors when a nucleic acid sequence coding for said gene is operatively linked to said isolated nucleic acid molecule.
Wind turbine with a rotor rotatable by way of wind power, which has a rotor hub and at least one rotor blade rotatably mounted thereon, a superordinate operational control apparatus and a blade angle adjustment system in communicative connection with said superordinate operational control apparatus and having components that can be used for the emergency shutdown of the wind turbine, by means of which blade angle adjustment system the rotor blade is rotatable relative to the rotor hub and therefore can be positioned in different blade angle positions, wherein control commands to position the rotor blade can be emitted from the operational control apparatus to the blade angle adjustment system and the blade angle adjustment system follows the control commands in a normal operation of the wind turbine and positions the rotor blade accordingly, wherein the blade angle adjustment system also has a monitoring unit that can operate parallel to normal operation, by means of which the functionality of the or a part of the components can be checked, characterised in that the operational control apparatus is connected to the blade angle adjustment system by way of at least one emergency shutdown control line, via which at least one periodic emergency shutdown control signal of defined frequency can be emitted from the operational control apparatus to the blade angle adjustment system, wherein the components comprise the emergency shutdown control line and in order to check the functionality of the emergency shutdown control line in normal operation at least the frequency of the emergency shutdown control signal can be checked by means of the monitoring unit.
A method for reporting a buffer status, comprising: when a terminal judges that there is a split bearer in a radio bearer or receives a notification transmitted by a base station that an additional buffer report is required to be reported, the terminal transmitting a Buffer Status Report, BSR, of the radio bearer to the base station; characterized in that the BSR carries size information about buffer data and size information about additional buffer data of the radio bearer; wherein when there are both a split bearer and a non-split bearer in the radio bearers, the size information about additional buffer data is size information about total buffer data of Packet Data Convergence Protocol, PDCP, layer corresponding to various split bearers in the radio bearers; and when all of the radio bearers are split bearers, the size information about additional buffer data is size information about total buffer data of the PDCP layer or Radio Link Control, RLC, layers. when a terminal judges that there is a split bearer in a radio bearer or receives a notification transmitted by a base station that an additional buffer report is required to be reported, the terminal transmitting a Buffer Status Report, BSR, of the radio bearer to the base station; characterized in that the BSR carries size information about buffer data and size information about additional buffer data of the radio bearer; wherein when there are both a split bearer and a non-split bearer in the radio bearers, the size information about additional buffer data is size information about total buffer data of Packet Data Convergence Protocol, PDCP, layer corresponding to various split bearers in the radio bearers; and when all of the radio bearers are split bearers, the size information about additional buffer data is size information about total buffer data of the PDCP layer or Radio Link Control, RLC, layers.
A device configured to perform calculations for determining a personalized estimate; the magnitude of an intended medical effect, a duration and a shape of this, for a drug, based on sections of data where a target glucose and dose history have been recorded, wherein the personalized estimate of a finite impulse-response model parameters a = [a 0, a 1... a n] and the basal hepatic glucose production G b is determined according to: I(t k) represents a drug infusion and y(t k) (i) is a glucose level at a time sample t k, v(t k) ∼ N(0, σ v) corresponds to a process noise perturbation with variance σ v 2, and T j represents the time instances in a dataset j, and where the finite impulse-response model parameters a = [a 0, a 1... a n] have a glucose dependence; for each glucose level G of interest, the following problem is solved to retrieve the parameter estimates; a and G b = [G b...G b] using N periods of data: subject to and wherein a second-order regularization matrix R is populated as follows: R j, j − 1: j + 1 = 1 − 2 1, j = 1,..., n wherein y j = y t 1 j... y t n j is the collected glucose data for data record j covering sample times T j = t 1 j... t n j, and y ^ j = y ^ t 1 j... y ^ t n j is the corresponding estimate of glucose level according to the equation; W G is the quadratic kernel matrix defining the weight of each glucose measurement according to the distance to the glucose level G; G b 0 is the prior expected value estimate of G b, and α, β and γ are penalty terms.
A spray treatment system for cleaning a surface of a part, the spray treatment system comprising: - a conveyor mechanism configured to support the part and to move the part along a cleaning path having a central axis; - a plurality of spray nozzles, each spray nozzle configured to spray a cleaning agent in form of a cleaning jet towards the part, wherein the spray nozzles are positioned along at least one side (91,92) of the cleaning path; - a part rotating mechanism configured to rotate the part about an axis of the part such that the part is aligned in different orientations with respect to the central axis of the cleaning path; characterized by - a 3D scanner (40,40') configured to scan the part to be cleaned to determine a shape and/or a size of the part and to generate data indicative of the shape and/or the size of the part to be cleaned; and - a processor configured to receive the data from the 3D scanner (40,40') and to direct the part rotating mechanism to orient the part based on the shape and/or the size of the part such that a surface portion (4,4') of the surface of the part is disposed at a predetermined distance from at least one spray nozzle from the plurality of spray nozzles. - a conveyor mechanism configured to support the part and to move the part along a cleaning path having a central axis; - a plurality of spray nozzles, each spray nozzle configured to spray a cleaning agent in form of a cleaning jet towards the part, wherein the spray nozzles are positioned along at least one side (91,92) of the cleaning path; - a part rotating mechanism configured to rotate the part about an axis of the part such that the part is aligned in different orientations with respect to the central axis of the cleaning path; - a 3D scanner (40,40') configured to scan the part to be cleaned to determine a shape and/or a size of the part and to generate data indicative of the shape and/or the size of the part to be cleaned; and - a processor configured to receive the data from the 3D scanner (40,40') and to direct the part rotating mechanism to orient the part based on the shape and/or the size of the part such that a surface portion (4,4') of the surface of the part is disposed at a predetermined distance from at least one spray nozzle from the plurality of spray nozzles.
A method of determining the immune repertoire in a subject, comprising: (a) reverse transcribing mRNA obtained from the subject to produce immunoglobulin chain cDNAs comprising a 3' homopolymer tail by using immunoglobulin chain specific primers and a reverse transcriptase; (b) adding a random molecular tag and a universal sequence to the 3' end of the immunoglobulin chain cDNAs to form extended cDNAs, by using the reverse transcriptase and oligonucleotides comprising a 3' sequence complementary to the homopolymer tail and a 5' flanking sequence comprising the universal sequence and the random molecular tag, wherein each extended cDNA is associated with a unique random molecular tag; (c) amplifying the extended cDNAs by using one or more immunoglobulin chain specific primers and a primer specific to the universal sequence and further comprising a sequencing platform specific flanking sequence to produce a plurality of molecular tagged immunoglobulin chain nucleic acids; and (d) sequencing the molecular tagged immunoglobulin chain nucleic acids to produce a plurality of sequencing reads thereby determining the immune repertoire of the subject. (a) reverse transcribing mRNA obtained from the subject to produce immunoglobulin chain cDNAs comprising a 3' homopolymer tail by using immunoglobulin chain specific primers and a reverse transcriptase; (b) adding a random molecular tag and a universal sequence to the 3' end of the immunoglobulin chain cDNAs to form extended cDNAs, by using the reverse transcriptase and oligonucleotides comprising a 3' sequence complementary to the homopolymer tail and a 5' flanking sequence comprising the universal sequence and the random molecular tag, wherein each extended cDNA is associated with a unique random molecular tag; (c) amplifying the extended cDNAs by using one or more immunoglobulin chain specific primers and a primer specific to the universal sequence and further comprising a sequencing platform specific flanking sequence to produce a plurality of molecular tagged immunoglobulin chain nucleic acids; and (d) sequencing the molecular tagged immunoglobulin chain nucleic acids to produce a plurality of sequencing reads thereby determining the immune repertoire of the subject.
A power control method for an image forming apparatus to control a heating roller, in which a roller power being supplied to a heating resistor included in the heating roller is in the form of an alternating current and is controlled in the image forming apparatus using the heating roller to fix a toner image, the power control method comprising, in the following order: supplying a source power supplied from an external source to the heating resistor as the roller power while gradually increasing a maximum level of the source power up to a specific maximum supply level; measuring a surface temperature of the heating roller, and supplying the source power having a maximum level at the specific maximum supply level to the heating resistor as the roller power until the measured surface temperature reaches a specific fixing target temperature; supplying the source power to the heating resistor as the roller power until a paper feed detecting unit of the image forming apparatus determines that a printing medium is first fed, a maximum level of the supplied source power having an upper limit equal to a specific fixing property improving level, wherein the specific fixing property improving level is less than the specific maximum supply level; and supplying a source power having a maximum level equal to a thermostat level of the heating resistor as the roller power and fixing a toner image of print data onto the fed printing medium by using the heating roller, wherein supplying of the source power having the upper limit of the maximum level at the specific fixing property improving level raises the surface temperature of a pressure roller of the image forming apparatus, which co-rotates with the heating roller, to reach the specific fixing target temperature. supplying a source power supplied from an external source to the heating resistor as the roller power while gradually increasing a maximum level of the source power up to a specific maximum supply level; measuring a surface temperature of the heating roller, and supplying the source power having a maximum level at the specific maximum supply level to the heating resistor as the roller power until the measured surface temperature reaches a specific fixing target temperature; supplying the source power to the heating resistor as the roller power until a paper feed detecting unit of the image forming apparatus determines that a printing medium is first fed, a maximum level of the supplied source power having an upper limit equal to a specific fixing property improving level, wherein the specific fixing property improving level is less than the specific maximum supply level; and supplying a source power having a maximum level equal to a thermostat level of the heating resistor as the roller power and fixing a toner image of print data onto the fed printing medium by using the heating roller, wherein supplying of the source power having the upper limit of the maximum level at the specific fixing property improving level raises the surface temperature of a pressure roller of the image forming apparatus, which co-rotates with the heating roller, to reach the specific fixing target temperature.
Motor-vehicle light comprising a rigid rear shell and, within said rigid rear shell, at least one cup-shaped body having its mouth faced to the mouth of the rigid rear shell, and at least one LED light source which is located close to the bottom of said cup-shaped body and is structured so to emit light when electricity powered; the motor-vehicle light furthermore comprises an essentially sheet-shaped intermediate lenticular body which is made of either transparent or semitransparent material, and is closing the mouth of the cup-shaped body so to be crossed by the light emitted by the LED light source; the motor-vehicle light being characterized in that the rear face of said intermediate lenticular body being provided with a plenty of crests or rectilinear grooves having a substantially cylindrical transversal profile, which are distributed on the surface of the lenticular body one parallel and adjacent to the other, so as to form a cylindrical-optics flat lens that extends substantially without interruption, along the portion of the intermediate lenticular body that is crossed by the light coming out from the mouth of the cup-shaped body; in that the pitch or centers-distance (p) between two adjacent crests or rectilinear grooves on the rear face of the intermediate lenticular body ranges between 0.15 and 1.2 millimeters; and in that the curvature radius (r) of the cylindrical profile of the rectilinear crests or grooves is lower than double the value of the pitch or centers-distance (p) existing between the crests or rectilinear grooves.
A shield system for a gas turbine engine comprising: an inner case structure; a vane pack; a vane mount portion; an inner portion configured for attachment to the inner case structure; and an outer portion spaced radially outward of the inner portion relative to an engine center axis and configured for attachment to the vane pack; said system including a first set of fasteners that attach the outer portion to the vane pack and a second set of fasteners that attach the inner portion to the inner case structure, characterised in that it includes a bushing that is clamped to the vane mount portion of the vane pack with a fastner from the first set of fasteners; such that the outer portion is prevented from axial movement relative to the vane pack while being capable of radial movement relative to the vane pack, and wherein the bushing includes a flange spaced from an aft end face of the vane mount portion such that the outer portion is positioned between the vane mounting portion and the flange.
At least one polypeptide (i) comprising or consisting of the sequence of the FERM domain of an ERM protein, or (ii) comprising or consisting of a sequence derived from the sequence of the FERM domain of an ERM protein by substitution, deletion, or insertion of at least one amino acid, provided that said polypeptide comprising or consisting of the sequence derived from the sequence of the FERM domain of an ERM protein prevents the ligand-independent activation of ErbB2 in cells, wherein when said sequence of the FERM domain of an ERM protein is SEQ ID NO: 1, said sequence derived therefrom is a mutant in which the tyrosine at position 353 is not mutated and the 149-168 domain is not mutated, for use as a medicament. (i) comprising or consisting of the sequence of the FERM domain of an ERM protein, or (ii) comprising or consisting of a sequence derived from the sequence of the FERM domain of an ERM protein by substitution, deletion, or insertion of at least one amino acid, provided that said polypeptide comprising or consisting of the sequence derived from the sequence of the FERM domain of an ERM protein prevents the ligand-independent activation of ErbB2 in cells, wherein when said sequence of the FERM domain of an ERM protein is SEQ ID NO: 1, said sequence derived therefrom is a mutant in which the tyrosine at position 353 is not mutated and the 149-168 domain is not mutated, for use as a medicament.