A dental medicament applicator comprising: a placement device sized for insertion at a dental site, the dental site being an interproximal site, the placement device including a central body, a first wing, and a second wing; the central body having a front, a rear, an upper end, a lower end, a first lateral end, and a second lateral end; the first wing having a proximal end and a distal end, the first wing being coupled to the first lateral end, the first wing providing subterminal opposition surfaces (54, 56, 58, 60) in which palmar surfaces of a thumb and an index finger can hold the first wing therebetween, the first wing having a transverse axis from the distal end to the proximal end, the transverse axis having a transverse length (L W1) greater than twice the mean width for a human tooth, the first wing being free of a topical substance for treating incipient lesions; the second wing having a proximal end and a distal end, the second wing being coupled to the second lateral end, the second wing providing subterminal opposition surfaces (94, 96, 98, 100) in which palmar surfaces of a thumb and an index finger can hold the second wing therebetween, the second wing having a transverse axis from the distal end to the proximal end, the transverse axis having a transverse length (L W2) greater than twice the mean width for a human tooth, the second wing being free of the topical substance; at least one active matrix secured to the front of the central body, the at least one active matrix containing the topical substance; each of the first wing and the second wing having a larger surface area than the at least one active matrix; the placement device, in response to being physically affixed to the dental site, dissolving at a first controlled rate; and the at least one active matrix, in response to being physically affixed to the dental site, delivering the topical substance at a second controlled rate to the dental site, the second controlled rate being slower in time than the first controlled rate. a placement device sized for insertion at a dental site, the dental site being an interproximal site, the placement device including a central body, a first wing, and a second wing; the central body having a front, a rear, an upper end, a lower end, a first lateral end, and a second lateral end; the first wing having a proximal end and a distal end, the first wing being coupled to the first lateral end, the first wing providing subterminal opposition surfaces (54, 56, 58, 60) in which palmar surfaces of a thumb and an index finger can hold the first wing therebetween, the first wing having a transverse axis from the distal end to the proximal end, the transverse axis having a transverse length (L W1) greater than twice the mean width for a human tooth, the first wing being free of a topical substance for treating incipient lesions; the second wing having a proximal end and a distal end, the second wing being coupled to the second lateral end, the second wing providing subterminal opposition surfaces (94, 96, 98, 100) in which palmar surfaces of a thumb and an index finger can hold the second wing therebetween, the second wing having a transverse axis from the distal end to the proximal end, the transverse axis having a transverse length (L W2) greater than twice the mean width for a human tooth, the second wing being free of the topical substance; at least one active matrix secured to the front of the central body, the at least one active matrix containing the topical substance; each of the first wing and the second wing having a larger surface area than the at least one active matrix; the placement device, in response to being physically affixed to the dental site, dissolving at a first controlled rate; and the at least one active matrix, in response to being physically affixed to the dental site, delivering the topical substance at a second controlled rate to the dental site, the second controlled rate being slower in time than the first controlled rate.