A syringe adapter comprising: a housing having a first end and a second end positioned opposite the first end, the housing including a connector body positioned at the first end of the housing and configured to be secured to a syringe barrel; a cannula positioned within the housing, the cannula having a first end and a second end opposite the first end, the cannula defining a transfer opening and a valve opening; a seal arrangement positioned within the housing and movable within the housing, the seal arrangement comprising a membrane; and characterized in an aspiration assembly positioned within the housing comprising: an aspiration housing defining an aspiration opening; a filter received by the aspiration housing; and a one-way valve received by the aspiration housing, wherein the valve opening of the cannula is positioned within the aspiration housing, wherein air is configured to flow into the filter via the aspiration opening, into the one-way valve, and into the valve opening of the cannula, and wherein the seal arrangement has a first position with the second end of the cannula received within the membrane of the seal arrangement and a second position with the second end of the cannula positioned outside of the membrane of the seal arrangement, the membrane of the seal arrangement engaging and sealing the aspiration opening of the aspiration housing when the seal arrangement is in the second position. a housing having a first end and a second end positioned opposite the first end, the housing including a connector body positioned at the first end of the housing and configured to be secured to a syringe barrel; a cannula positioned within the housing, the cannula having a first end and a second end opposite the first end, the cannula defining a transfer opening and a valve opening; a seal arrangement positioned within the housing and movable within the housing, the seal arrangement comprising a membrane; and characterized in an aspiration assembly positioned within the housing comprising: an aspiration housing defining an aspiration opening; a filter received by the aspiration housing; and a one-way valve received by the aspiration housing, wherein the valve opening of the cannula is positioned within the aspiration housing, wherein air is configured to flow into the filter via the aspiration opening, into the one-way valve, and into the valve opening of the cannula, and wherein the seal arrangement has a first position with the second end of the cannula received within the membrane of the seal arrangement and a second position with the second end of the cannula positioned outside of the membrane of the seal arrangement, the membrane of the seal arrangement engaging and sealing the aspiration opening of the aspiration housing when the seal arrangement is in the second position. an aspiration housing defining an aspiration opening; a filter received by the aspiration housing; and a one-way valve received by the aspiration housing, wherein the valve opening of the cannula is positioned within the aspiration housing, wherein air is configured to flow into the filter via the aspiration opening, into the one-way valve, and into the valve opening of the cannula, and wherein the seal arrangement has a first position with the second end of the cannula received within the membrane of the seal arrangement and a second position with the second end of the cannula positioned outside of the membrane of the seal arrangement, the membrane of the seal arrangement engaging and sealing the aspiration opening of the aspiration housing when the seal arrangement is in the second position.