A method of detecting a genetic event, the method comprising the steps of: a) partitioning a sample from a subject into a plurality of partitions, wherein said partitions comprise an amplification mixture comprising: i. a polymerase; ii. at least two pairs of nucleic acid primers, each pair of nucleic acid primers being capable of hybridizing to a respective nucleic acid target of the genetic event; and iii. at least two nucleic acid probes, each nucleic acid probe being capable of hybridizing to a respective nucleic acid target of the genetic event, and being attached or linked to a different detectable fluorescent label, the different detectable fluorescent labels having non-overlapping excitation wavelength ranges and/or non-overlapping emission wavelength ranges; b) performing a digital polymerase chain reaction (dPCR) assay on the plurality of partitions under conditions suitable to amplify, if present, each nucleic acid target of the genetic event; c) providing a conclusion regarding the presence of said genetic event based on whether fluorescence in at least one partition of the plurality of partitions is detected or not, wherein fluorescence in a given partition is indicative of amplification of at least one nucleic acid target of the genetic event in said given partition; wherein the at least two nucleic acid targets are located, upon spontaneous and/or artificial fragmentation of nucleic acids in the sample, on separate fragments of said nucleic acids, thereby statistically behaving independently from each other during partitioning of the sample into a plurality of partitions, and therefore behaving independently from each other in the dPCR assay, the genetic event being a monosomy, a trisomy or a tetrasomy. a) partitioning a sample from a subject into a plurality of partitions, wherein said partitions comprise an amplification mixture comprising: i. a polymerase; ii. at least two pairs of nucleic acid primers, each pair of nucleic acid primers being capable of hybridizing to a respective nucleic acid target of the genetic event; and iii. at least two nucleic acid probes, each nucleic acid probe being capable of hybridizing to a respective nucleic acid target of the genetic event, and being attached or linked to a different detectable fluorescent label, the different detectable fluorescent labels having non-overlapping excitation wavelength ranges and/or non-overlapping emission wavelength ranges; i. a polymerase; ii. at least two pairs of nucleic acid primers, each pair of nucleic acid primers being capable of hybridizing to a respective nucleic acid target of the genetic event; and iii. at least two nucleic acid probes, each nucleic acid probe being capable of hybridizing to a respective nucleic acid target of the genetic event, and being attached or linked to a different detectable fluorescent label, the different detectable fluorescent labels having non-overlapping excitation wavelength ranges and/or non-overlapping emission wavelength ranges; b) performing a digital polymerase chain reaction (dPCR) assay on the plurality of partitions under conditions suitable to amplify, if present, each nucleic acid target of the genetic event; c) providing a conclusion regarding the presence of said genetic event based on whether fluorescence in at least one partition of the plurality of partitions is detected or not, wherein fluorescence in a given partition is indicative of amplification of at least one nucleic acid target of the genetic event in said given partition; wherein the at least two nucleic acid targets are located, upon spontaneous and/or artificial fragmentation of nucleic acids in the sample, on separate fragments of said nucleic acids, thereby statistically behaving independently from each other during partitioning of the sample into a plurality of partitions, and therefore behaving independently from each other in the dPCR assay, the genetic event being a monosomy, a trisomy or a tetrasomy.