Drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the device comprising: a housing, a dose setting element rotatable relative to the housing during dose setting and dose dispensing, a drive member coupled to the dose setting member via a clutch, a piston rod coupled to the housing and to the drive member, a cartridge holder removably attached to the housing and a reset element, which is permanently rotationally constrained to the housing and rotationally constrained to the drive member during dose setting, characterized in that the device further comprises at least one spring (130, 160) acting on the reset element, such that, if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing into a position in which the drive member is allowed to rotate relative to the housing, and in that the device further comprises a clutch (64, 153) which is decoupled if the cartridge holder is attached to the housing and which is coupled if the cartridge holder is detached from the housing, wherein the clutch (64, 153) rotationally couples the dose setting element and the reset element, wherein the reset element comprises clutch teeth and the drive member comprises corresponding clutch teeth for releasably rotationally constraining the reset element and the drive member depending on the relative axial positions of the reset element and the drive member, and wherein the drive member is axially movable relative to the housing between a dose setting position in which, if the cartridge holder is attached to the housing, the drive member is rotationally constrained to the housing via the reset element and a dose dispensing position in which, if the cartridge holder is attached to the housing, the drive member is rotatable relative to the reset element and the housing. a housing, a dose setting element rotatable relative to the housing during dose setting and dose dispensing, a drive member coupled to the dose setting member via a clutch, a piston rod coupled to the housing and to the drive member, a cartridge holder removably attached to the housing and a reset element, which is permanently rotationally constrained to the housing and rotationally constrained to the drive member during dose setting, characterized in that the device further comprises at least one spring (130, 160) acting on the reset element, such that, if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing into a position in which the drive member is allowed to rotate relative to the housing, and in that the device further comprises a clutch (64, 153) which is decoupled if the cartridge holder is attached to the housing and which is coupled if the cartridge holder is detached from the housing, wherein the clutch (64, 153) rotationally couples the dose setting element and the reset element, wherein the reset element comprises clutch teeth and the drive member comprises corresponding clutch teeth for releasably rotationally constraining the reset element and the drive member depending on the relative axial positions of the reset element and the drive member, and wherein the drive member is axially movable relative to the housing between a dose setting position in which, if the cartridge holder is attached to the housing, the drive member is rotationally constrained to the housing via the reset element and a dose dispensing position in which, if the cartridge holder is attached to the housing, the drive member is rotatable relative to the reset element and the housing.