A compound having a structure represented by Formula: wherein, n1 is an integer of 1-2, and n3 is an integer of 0-1, and n1+n3=2-3; each of m1, m2, and m3 is independently an integer of 2-10; each of R 10, R 11, R 12, R 13, R 14 and R 15 is independently selected from H, C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, and C 1 -C 10 alkoxy; R 4 is a moiety capable of binding to an active drug or active agent via a covalent bond; each L 1 is a linear alkylene of 1 to 70 carbon atoms in length, wherein one or more carbon atoms are optionally replaced with any one or more of the group consisting of: C, NH, O, S, CH=N, S 2, C 2 -C 10 alkenylene, C 2 -C 10 alkynylene, C 6 -C 10 arylene, C 3 -C 18 heterocyclylene, and C 5 -C 10 heteroarylene, and wherein L 1 is optionally substituted by any one or more of the group consisting of: C 1 -C 10 alkyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 1 -C 10 haloalkyl, -OC 1 -C 10 alkyl, -OC 1 -C 10 alkylphenyl, -C 1 -C 10 alkyl-OH, -OC 1 -C 10 haloalkyl, -SC 1 -C 10 alkyl, -SC 1 -C 10 alkylphenyl, -C 1 -C 10 alkyl-SH, -SC 1 -C 10 haloalkyl, halo, -OH, -SH, -NH 2, -C 1 -C 10 alkyl-NH 2, -N(C 1 -C 10 alkyl)(C 1 -C 10 alkyl), -NH(C 1 -C 10 alkyl), -N(C 1 -C 10 alkyl)(C 1 -C 10 alkylphenyl), -NH(C 1 -C 10 alkylphenyl), cyano, nitro, -CO 2 H, -C OC 1 -C 10 alkyl, -CON(C 1 -C 10 alkyl)(C 1 -C 10 alkyl), -CONH(C 1 -C 10 alkyl), -CONH 2, -NHC (C 1 -C 10 alkyl), -NHC (phenyl), -N(C 1 -C 10 alkyl)C (C 1 -C 10 alkyl), -N(C 1 -C 10 alkyl)C (phenyl), -C C 1 -C 10 alkyl, -C C 1 -C 10 alkylphenyl, -C C 1 -C 10 haloalkyl, -OC C 1 -C 10 alkyl, -SO 2 (C 1 -C 10 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 10 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 10 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 10 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 10 haloalkyl); each S 1 is independently an M 1, wherein any active hydroxyl, if any, is protected with a hydroxyl protecting group; each M 1 is independently selected from a ligand capable of binding to a cell surface receptor; and wherein the receptor is an asialoglycoprotein receptor on human hepatocytes. n1 is an integer of 1-2, and n3 is an integer of 0-1, and n1+n3=2-3; each of m1, m2, and m3 is independently an integer of 2-10; each of R 10, R 11, R 12, R 13, R 14 and R 15 is independently selected from H, C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, and C 1 -C 10 alkoxy; R 4 is a moiety capable of binding to an active drug or active agent via a covalent bond; each L 1 is a linear alkylene of 1 to 70 carbon atoms in length, wherein one or more carbon atoms are optionally replaced with any one or more of the group consisting of: C, NH, O, S, CH=N, S 2, C 2 -C 10 alkenylene, C 2 -C 10 alkynylene, C 6 -C 10 arylene, C 3 -C 18 heterocyclylene, and C 5 -C 10 heteroarylene, and wherein L 1 is optionally substituted by any one or more of the group consisting of: C 1 -C 10 alkyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 1 -C 10 haloalkyl, -OC 1 -C 10 alkyl, -OC 1 -C 10 alkylphenyl, -C 1 -C 10 alkyl-OH, -OC 1 -C 10 haloalkyl, -SC 1 -C 10 alkyl, -SC 1 -C 10 alkylphenyl, -C 1 -C 10 alkyl-SH, -SC 1 -C 10 haloalkyl, halo, -OH, -SH, -NH 2, -C 1 -C 10 alkyl-NH 2, -N(C 1 -C 10 alkyl)(C 1 -C 10 alkyl), -NH(C 1 -C 10 alkyl), -N(C 1 -C 10 alkyl)(C 1 -C 10 alkylphenyl), -NH(C 1 -C 10 alkylphenyl), cyano, nitro, -CO 2 H, -C OC 1 -C 10 alkyl, -CON(C 1 -C 10 alkyl)(C 1 -C 10 alkyl), -CONH(C 1 -C 10 alkyl), -CONH 2, -NHC (C 1 -C 10 alkyl), -NHC (phenyl), -N(C 1 -C 10 alkyl)C (C 1 -C 10 alkyl), -N(C 1 -C 10 alkyl)C (phenyl), -C C 1 -C 10 alkyl, -C C 1 -C 10 alkylphenyl, -C C 1 -C 10 haloalkyl, -OC C 1 -C 10 alkyl, -SO 2 (C 1 -C 10 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 10 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 10 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 10 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 10 haloalkyl); each S 1 is independently an M 1, wherein any active hydroxyl, if any, is protected with a hydroxyl protecting group; each M 1 is independently selected from a ligand capable of binding to a cell surface receptor; and wherein the receptor is an asialoglycoprotein receptor on human hepatocytes.