An automated processing system for transforming a spatio-temporal input data signal into a spatio- temporal output data signal, the system comprising: - an in vitro biological culture of neural cells (BNN culture) in a BNN core unit, wherein the neural cells are derived from rat stem cells or from human neural stem cells, excluding human Pluripotent Stem cells (PSc) obtained from human embryos; - an input stimulation unit SU adapted to apply an input spatio-temporal stimulation signal into a first set of the neural cells; - an output readout unit RU adapted to capture an output spatio-temporal readout signal from a second set of the neural cells; - one or more nutrient tanks in connection with one or more nutrient dispensers to inject one or more nutrients into the BNN culture; - one or more additive tanks (321, 323) each in connection with one or more additive dispensers (322, 324) to inject one or more additives into the BNN culture, the additives being chosen among a dopaminergic stimulation enhancer to increase the dopaminergic response of the BNN, a dopaminergic stimulation inhibitor to decrease the dopaminergic response of the BNN, botox, nicotine, curare, MDMA, strychnine, THC, caffeine, benzodiazepines, growth factors, hormone, CO 2 or a combination thereof; - one or more nutrient waste collectors, for filtering and expelling nutrient waste from the BNN culture; - one or more additive waste collectors (326, 327), for filtering and expelling additive waste from the BNN culture; - one or more vascularization networks to connect said nutrient dispensers, additive dispensers (322, 324), nutrient waste collectors and additive waste collectors (326, 327) to the BNN culture; - one or more sensors to measure at least one environmental parameter of the BNN culture; - an automation controller configured to adapt the stimulation signal to the input data signal, to adapt the output data signal to the readout signal and to control at least one of: - a BNN core unit environmental parameter; - a BNN culture nutrient supply; - a BNN culture additive supply; - a BNN culture nutrient waste collection; - a BNN culture additive waste collection; to maintain the homeostasis of the BNN culture over time so that the spatio-temporal input data signal is continuously transformed into the spatio-temporal output data signal, wherein the automation controller further comprises a pre-processing unit to transform the input data signal into the stimulation signal and wherein signal pre-processing comprises applying a repeated over time input data signal or varied over time input data signal. - an in vitro biological culture of neural cells (BNN culture) in a BNN core unit, wherein the neural cells are derived from rat stem cells or from human neural stem cells, excluding human Pluripotent Stem cells (PSc) obtained from human embryos; - an input stimulation unit SU adapted to apply an input spatio-temporal stimulation signal into a first set of the neural cells; - an output readout unit RU adapted to capture an output spatio-temporal readout signal from a second set of the neural cells; - one or more nutrient tanks in connection with one or more nutrient dispensers to inject one or more nutrients into the BNN culture; - one or more additive tanks (321, 323) each in connection with one or more additive dispensers (322, 324) to inject one or more additives into the BNN culture, the additives being chosen among a dopaminergic stimulation enhancer to increase the dopaminergic response of the BNN, a dopaminergic stimulation inhibitor to decrease the dopaminergic response of the BNN, botox, nicotine, curare, MDMA, strychnine, THC, caffeine, benzodiazepines, growth factors, hormone, CO 2 or a combination thereof; - one or more nutrient waste collectors, for filtering and expelling nutrient waste from the BNN culture; - one or more additive waste collectors (326, 327), for filtering and expelling additive waste from the BNN culture; - one or more vascularization networks to connect said nutrient dispensers, additive dispensers (322, 324), nutrient waste collectors and additive waste collectors (326, 327) to the BNN culture; - one or more sensors to measure at least one environmental parameter of the BNN culture; - an automation controller configured to adapt the stimulation signal to the input data signal, to adapt the output data signal to the readout signal and to control at least one of: - a BNN core unit environmental parameter; - a BNN culture nutrient supply; - a BNN culture additive supply; - a BNN culture nutrient waste collection; - a BNN culture additive waste collection; to maintain the homeostasis of the BNN culture over time so that the spatio-temporal input data signal is continuously transformed into the spatio-temporal output data signal, wherein the automation controller further comprises a pre-processing unit to transform the input data signal into the stimulation signal and wherein signal pre-processing comprises applying a repeated over time input data signal or varied over time input data signal.