A scientific instrument, comprising: a material analysis chamber having an input port; an injector (208, 304) configured to insert one material sample from a plurality of material samples into the material analysis chamber via the input port, wherein the material analysis chamber is configured to perform a scientific analysis of the inserted material sample, wherein the plurality of material samples includes at least one diagnostic material sample (204, 306); a data processor having a memory storing correlation data for comparing a first set of results of a first scientific analysis to expected results associated with the at least one diagnostic material sample to form a first set of compared results, wherein the data processor is further configured to selectively generate an output report of the first set of compared results; and a controller operatively coupled with the material analysis chamber, and the injector (208, 304), and the data processor, wherein the controller is configured to receive a first command via a user input feature, characterized in that, upon receiving the first command at the user input feature, the controller is configured to autonomously initiate and direct an evaluation of the health of the scientific instrument by: directing the injector (208, 304) to inject at least one diagnostic material sample that is formulated to test different aspects of chromatography into the material analysis chamber, initiating the scientific analysis to formulate the first set of results, directing the data processor to analyze the first set of results and to generate the first set of compared results, and directing the data processor to generate a first output report illustrating the first set of compared results indicative of the health of the scientific instrument. a material analysis chamber having an input port; an injector (208, 304) configured to insert one material sample from a plurality of material samples into the material analysis chamber via the input port, wherein the material analysis chamber is configured to perform a scientific analysis of the inserted material sample, wherein the plurality of material samples includes at least one diagnostic material sample (204, 306); a data processor having a memory storing correlation data for comparing a first set of results of a first scientific analysis to expected results associated with the at least one diagnostic material sample to form a first set of compared results, wherein the data processor is further configured to selectively generate an output report of the first set of compared results; and a controller operatively coupled with the material analysis chamber, and the injector (208, 304), and the data processor, wherein the controller is configured to receive a first command via a user input feature, characterized in that, upon receiving the first command at the user input feature, the controller is configured to autonomously initiate and direct an evaluation of the health of the scientific instrument by: directing the injector (208, 304) to inject at least one diagnostic material sample that is formulated to test different aspects of chromatography into the material analysis chamber, initiating the scientific analysis to formulate the first set of results, directing the data processor to analyze the first set of results and to generate the first set of compared results, and directing the data processor to generate a first output report illustrating the first set of compared results indicative of the health of the scientific instrument. directing the injector (208, 304) to inject at least one diagnostic material sample that is formulated to test different aspects of chromatography into the material analysis chamber, initiating the scientific analysis to formulate the first set of results, directing the data processor to analyze the first set of results and to generate the first set of compared results, and directing the data processor to generate a first output report illustrating the first set of compared results indicative of the health of the scientific instrument.