A compound of Formula, or a pharmaceutically acceptable salt, or solvate thereof: wherein, is C 3 -C 10 cycloalkyl, for example C 4 -C 7 cycloalkyl; each R 1 is independently -OR 6a, -SR 6a, -S(=O)R 7, -S(=O) 2 R 7, or -N(R 6b) 2; Y 5 is CR 4; Y 1, Y 2, Y 3, and Y 4 are each independently selected from CR 5 or Y 2 is nitrogen and Y 1, Y 3 and Y 4 are each independently CR 5; each R 6a is independently H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 1 -C 4 fluoroalkyl, -X-optionally substituted C 1 -C 4 alkyl, -X-optionally substituted C 1 -C 4 heteroalkyl, -X-optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 3 -C 4 cycloalkylC 1 -C 3 alkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; each R 6b is independently H or optionally substituted C 1 -C 3 alkyl, for example wherein each R 6b is independently H, -CH 2 CH 2 CH 3, -CH 2 CH 3, or -CH 3; or two R 6b are taken together with the N atom to which they are attached to form an optionally substituted heterocycle, for example optionally substituted heterocycle selected from piperidinyl, morpholinyl, and thiomorpholinyl; X is -C(=O)-; each R 7 is independently optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; A 2 is N or CR A; R A is H; R A1, R A2, R A3 and R A4 are each independently H, optionally substituted C 1 -C 4 alkyl or optionally substituted C 1 -C 4 fluoroalkyl; is phenylene or a 6-membered heteroarylene ring comprising 1 or 2 nitrogen atoms in the ring, for example pyridinylene, pyrimidinylene, pyrazinylene, or pyridazinylene; B is each R 3 is independently halogen, -CN, -OR 11, -SR 11, optionally substituted C 1 -C 4 alkyl or optionally substituted C 1 -C 4 fluoroalkyl; each R 11 is independently H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; n is 0, 1, 2, 3, or 4, for example n is 0 or 1; p is 1, 2, or 3, for example p is 1; q is 0; R 4 is halogen, for example Cl; each R 5 are each independently H or halogen, for example each R 5 is independently H or -Cl; and R 13 is H or unsubstituted C 1 -C 4 alkyl, for example R 13 is H. each R 1 is independently -OR 6a, -SR 6a, -S(=O)R 7, -S(=O) 2 R 7, or -N(R 6b) 2; Y 5 is CR 4; Y 1, Y 2, Y 3, and Y 4 are each independently selected from CR 5 or Y 2 is nitrogen and Y 1, Y 3 and Y 4 are each independently CR 5; each R 6a is independently H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 1 -C 4 fluoroalkyl, -X-optionally substituted C 1 -C 4 alkyl, -X-optionally substituted C 1 -C 4 heteroalkyl, -X-optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 3 -C 4 cycloalkylC 1 -C 3 alkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; each R 6b is independently H or optionally substituted C 1 -C 3 alkyl, for example wherein each R 6b is independently H, -CH 2 CH 2 CH 3, -CH 2 CH 3, or -CH 3; or two R 6b are taken together with the N atom to which they are attached to form an optionally substituted heterocycle, for example optionally substituted heterocycle selected from piperidinyl, morpholinyl, and thiomorpholinyl; X is -C(=O)-; each R 7 is independently optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; A 2 is N or CR A; R A is H; R A1, R A2, R A3 and R A4 are each independently H, optionally substituted C 1 -C 4 alkyl or optionally substituted C 1 -C 4 fluoroalkyl; is phenylene or a 6-membered heteroarylene ring comprising 1 or 2 nitrogen atoms in the ring, for example pyridinylene, pyrimidinylene, pyrazinylene, or pyridazinylene; B is each R 3 is independently halogen, -CN, -OR 11, -SR 11, optionally substituted C 1 -C 4 alkyl or optionally substituted C 1 -C 4 fluoroalkyl; each R 11 is independently H, optionally substituted C 1 -C 4 alkyl, optionally substituted C 1 -C 4 fluoroalkyl, optionally substituted C 1 -C 4 heteroalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 10 heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; n is 0, 1, 2, 3, or 4, for example n is 0 or 1; p is 1, 2, or 3, for example p is 1; q is 0; R 4 is halogen, for example Cl; each R 5 are each independently H or halogen, for example each R 5 is independently H or -Cl; and R 13 is H or unsubstituted C 1 -C 4 alkyl, for example R 13 is H.