mhurhangee/ep-ind-claims huggingface dataset:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein: X is A is fluorophenyl; B is b) -C CH=C(CH 3) 2; c) Ar; d) -C -Ar; e) -C CHR y -Ar; f) -C CH(NHR x)-Ar; g) -SO 2 (CH 2) 0-2 -Ar; h) -SO 2 -CH=CH-Ar; i) -CO-Cyc; j) -COCH 2 -Cyc; k) -SO 2 -Cyc; Ar is an aromatic ring system selected from: (i) 5-6 membered monocyclic ring with 0, 1, or 2 heteroatom ring atoms independently selected from N or O, optionally substituted with 1 or 2 substituents independently selected from fluorophenyl, C 1 -C 6 alkyl, and halo; and (ii) 8-10 membered bicyclic rings with 1, 2 or 3 heteroatom ring atoms selected from N, O and S, optionally substituted with 1, 2 or 3 substituents independently selected from C 1- C 6 alkyl, C 1- C 6 alkoxy, halo, CF 3, cyano, oxo, -NH 2, and cyclopropylmethyl; Cyc is C 3 -C 6 cycloalkyl optionally substituted with fluorophenyl or pyridine; or 3-oxabicyclo[3.1.0]hexane; D is NR 3 SO 2 R 4; R 2, R 3, and R 4 are independently C 1 -C 6 alkyl; R a is hydrogen or C 1 -C 6 alkyl; R x is hydrogen or C OC(CH 3) 3; and R y is hydrogen, morpholinyl or Ar. X is A is fluorophenyl; B is b) -C CH=C(CH 3) 2; c) Ar; d) -C -Ar; e) -C CHR y -Ar; f) -C CH(NHR x)-Ar; g) -SO 2 (CH 2) 0-2 -Ar; h) -SO 2 -CH=CH-Ar; i) -CO-Cyc; j) -COCH 2 -Cyc; k) -SO 2 -Cyc; b) -C CH=C(CH 3) 2; c) Ar; d) -C -Ar; e) -C CHR y -Ar; f) -C CH(NHR x)-Ar; g) -SO 2 (CH 2) 0-2 -Ar; h) -SO 2 -CH=CH-Ar; i) -CO-Cyc; j) -COCH 2 -Cyc; k) -SO 2 -Cyc; Ar is an aromatic ring system selected from: (i) 5-6 membered monocyclic ring with 0, 1, or 2 heteroatom ring atoms independently selected from N or O, optionally substituted with 1 or 2 substituents independently selected from fluorophenyl, C 1 -C 6 alkyl, and halo; and (ii) 8-10 membered bicyclic rings with 1, 2 or 3 heteroatom ring atoms selected from N, O and S, optionally substituted with 1, 2 or 3 substituents independently selected from C 1- C 6 alkyl, C 1- C 6 alkoxy, halo, CF 3, cyano, oxo, -NH 2, and cyclopropylmethyl; (i) 5-6 membered monocyclic ring with 0, 1, or 2 heteroatom ring atoms independently selected from N or O, optionally substituted with 1 or 2 substituents independently selected from fluorophenyl, C 1 -C 6 alkyl, and halo; and (ii) 8-10 membered bicyclic rings with 1, 2 or 3 heteroatom ring atoms selected from N, O and S, optionally substituted with 1, 2 or 3 substituents independently selected from C 1- C 6 alkyl, C 1- C 6 alkoxy, halo, CF 3, cyano, oxo, -NH 2, and cyclopropylmethyl; Cyc is C 3 -C 6 cycloalkyl optionally substituted with fluorophenyl or pyridine; or 3-oxabicyclo[3.1.0]hexane; D is NR 3 SO 2 R 4; R 2, R 3, and R 4 are independently C 1 -C 6 alkyl; R a is hydrogen or C 1 -C 6 alkyl; R x is hydrogen or C OC(CH 3) 3; and R y is hydrogen, morpholinyl or Ar.
A polymer composition comprising: a diene-based polymer; and a filler, wherein the diene-based polymer contains a polymer and a polymer, polymer: a diene-based polymer that is a polymer of a conjugate diene compound or a copolymer of a conjugate diene compound and an aromatic vinyl compound, the diene-based polymer being modified with a polar group having affinity for the filler, in which an aromatic vinyl content is 25 mass% or less, and a modification rate is 30-100%, and polymer: a diene-based polymer that is a copolymer of an aromatic vinyl compound and a conjugate diene compound containing 1,3-butadiene, in which an aromatic vinyl content is 30-50 mass%, a vinyl content is 5-30 mass%, and a peak molecular weight in terms of polystyrene measured by gel permeation chromatography is 400,000 to 2,000,000, and a ratio of a weight-average molecular weight to a number-average molecular weight of the polymer is 1.5 to 3.0. a diene-based polymer; and a filler, wherein the diene-based polymer contains a polymer and a polymer, polymer: a diene-based polymer that is a polymer of a conjugate diene compound or a copolymer of a conjugate diene compound and an aromatic vinyl compound, the diene-based polymer being modified with a polar group having affinity for the filler, in which an aromatic vinyl content is 25 mass% or less, and a modification rate is 30-100%, and polymer: a diene-based polymer that is a copolymer of an aromatic vinyl compound and a conjugate diene compound containing 1,3-butadiene, in which an aromatic vinyl content is 30-50 mass%, a vinyl content is 5-30 mass%, and a peak molecular weight in terms of polystyrene measured by gel permeation chromatography is 400,000 to 2,000,000, and a ratio of a weight-average molecular weight to a number-average molecular weight of the polymer is 1.5 to 3.0.
A system for treating an aneurysm, said system comprising: at least a first double-walled filling structure (12; 112) having an outer wall (24; 124) and an inner wall (26; 126), wherein the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow, wherein the first filling structure comprises a sealing feature (608, 610; 620), the sealing feature forming a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal wherein the sealing feature comprises a shaped region disposed near an upper portion of the first filling structure so as to be disposed in a neck of the aneurysm and/or upstream of the aneurysm when the filling structure is deployed, wherein the sealing feature comprises a tapered upper portion _ forming a flat surface configured to form a seal with the inside surface of the aneurysm.
A method of encoding RFID transponders on a continuous moving web, the method comprising the steps of: determining if a RF field is capable of encoding the RFID transponders at a selected continuous web speed; if the selected continuous web speed is too high to encode the RFID transponders, determining a continuous lower web speed at which to encode the RFID transponders based on the RF field length; and adjusting the web speed to the determined continuous web speed to encode the RFID transponders, characterized in that the determined continuous web speed capable of encoding RFID transponders is calculated during a calibration sequence, wherein the calibration sequence comprises the steps of: initiating web motion; detecting a RFID transponder in the RF field; counting a number of steps taken by a stepper motor for driving the RFID transponder during which steps the transponder remains in the RF field; and determining the RF field length based on an average of captured RFID transponder counted steps for a plurality of RFID transponders. determining if a RF field is capable of encoding the RFID transponders at a selected continuous web speed; if the selected continuous web speed is too high to encode the RFID transponders, determining a continuous lower web speed at which to encode the RFID transponders based on the RF field length; and adjusting the web speed to the determined continuous web speed to encode the RFID transponders, initiating web motion; detecting a RFID transponder in the RF field; counting a number of steps taken by a stepper motor for driving the RFID transponder during which steps the transponder remains in the RF field; and determining the RF field length based on an average of captured RFID transponder counted steps for a plurality of RFID transponders.
A SKI inhibitor in combination with an immune checkpoint inhibitor for use in the treatment of cancer in a subject in need thereof, wherein the immune checkpoint inhibitor is an antibody selected from the group consisting of anti-CTLA4 antibodies and anti-PD-1 antibodies.
Radiating element (700, 800) comprising at least two feeding guides and one horn common to the at least two feeding guides and having an excitation interface, each feeding guide being distinct from the other feeding guides, each feeding guide consisting of a port guide (701, 711, 801) and an excitation guide (702, 712, 802) connected to the port guide (701, 711, 801) by a port interface and connected to the common horn by the excitation interface, each excitation guide (702, 712, 802) being flared in the direction from the port interface to the excitation interface, each excitation guide (702, 712, 802) not having an axis of symmetry, the at least two feeding guides being identical and disposed symmetrically relative to one another relative to a plane of symmetry of the radiating element.
A method for diagnosing pancreas cancer in a subject comprising the steps of: (a) determining in a sample of a subject suspected to suffer from pancreas cancer the amount of the at least one biomarker Sphingomyelin (d18:1, C20:1), and (b) comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. (a) determining in a sample of a subject suspected to suffer from pancreas cancer the amount of the at least one biomarker Sphingomyelin (d18:1, C20:1), and (b) comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed.
A pick tool for degrading asphalt, comprising a PCD element; the PCD element comprising a PCD structure bonded to a cemented carbide support body at an interface; the PCD structure comprising a first region and a second region adjacent the first region, the second region bonded to the first region by intergrowth of diamond grains; the first region comprising a plurality of alternating strata (24t, 24c), each stratum having a thickness in the range of 30 to 300 microns; the second region comprising a plurality of strata (25a, 25b, 25c), one or more strata in the second region having a thickness greater than the thicknesses of the individual strata in the first region, wherein the alternating strata in the first region comprise first strata alternating with second strata, the first strata being in a state of residual compressive stress and the second strata being in a state of residual tensile stress; characterised in that the PCD structure defines a working end including a rounded conical apex having a radius of curvature of 1.3 mm to 3.2 mm and is 2.5 mm to 10 mm thick from the apex to the interface.
An RPG defeat method comprising: placing a porous body on or in proximity to a vehicle or structure; a plug of the porous body being displaced by an incoming RPG forming a channel in the porous body allowing an RPG sensor to enter the channel in the porous body without the RPG sensor signaling the RPG detonator; the method being characterized by the porous body material proximate the channel deforming the RPG nose cone and short circuiting the electrical connection between the RPO sensor and detonator before the RPG sensor strikes the vehicle or structure. placing a porous body on or in proximity to a vehicle or structure; a plug of the porous body being displaced by an incoming RPG forming a channel in the porous body allowing an RPG sensor to enter the channel in the porous body without the RPG sensor signaling the RPG detonator; the method being characterized by the porous body material proximate the channel deforming the RPG nose cone and short circuiting the electrical connection between the RPO sensor and detonator before the RPG sensor strikes the vehicle or structure.
A connector including a connector housing formed in a tubular shape by an insulating synthetic resin, a cover for closing an opening of one end side in an axial direction of the connector housing, and plural terminal fittings formed inside the connector housing, one end of the terminal fittings each being arranged in an opening for coupling of the other end side in the axial direction of the connector housing and the other end of the terminal fittings each being connected to one end of an electric wire, wherein the one end of the terminal fittings each led out of one inner wall part of the connector housing traverses the opening for coupling,, characterized in that the plural terminal fittings are formed inside the connector housing by insert molding, a distal end of the terminal fittings each is buried in the other inner wall part opposed to the one inner wall part, and the distal end is folded inside the other inner wall part.
An inventory tracking system comprising: a mobile structure with a reading zone configured to receive one or more electronically labelled items on a horizontal reading surface; and a near field electronic reader comprising at least one omnidirectional reader antenna associated with the reading zone, wherein the electronic reader is configured to read electronic labels of the one or more electronically labelled items placed on the horizontal reading surface with random orientations, wherein the reading zone associated with the reader antenna is a three-dimensional reading zone that operates up to a distance of 0.5m, characterized in that the three-dimensional reading zone is configurable by one or more of: varying the power to one or more antenna coils of the at least one omnidirectional reader antenna, and switching individual antenna coils, thereby altering dimensions of the three-dimensional reading zone; and the inventory tracking system further comprises a user interface, and the reading zone is configurable via the user interface. a mobile structure with a reading zone configured to receive one or more electronically labelled items on a horizontal reading surface; and a near field electronic reader comprising at least one omnidirectional reader antenna associated with the reading zone, wherein the electronic reader is configured to read electronic labels of the one or more electronically labelled items placed on the horizontal reading surface with random orientations, wherein the reading zone associated with the reader antenna is a three-dimensional reading zone that operates up to a distance of 0.5m, characterized in that the three-dimensional reading zone is configurable by one or more of: varying the power to one or more antenna coils of the at least one omnidirectional reader antenna, and switching individual antenna coils, thereby altering dimensions of the three-dimensional reading zone; and the inventory tracking system further comprises a user interface, and the reading zone is configurable via the user interface.
A light curing apparatus comprising a control circuit by which the light curing apparatus can be switched on and/or off, in particular from a standby mode to an operating mode and vice versa, and a sensor to cause switching on and/or switching off, characterized in that the light curing apparatus Is provided with a sensor to cause switching on and/or switching off, in that the sensor is designed as a capacitive proximity sensor which has a sensitivity of less than 1 pF, and in that the control circuit distinguishes between the approach of a user's hand to the light curing device and the approach of the light curing device to a support.
A steel material comprising a chemical composition consisting of, in mass%, C: more than 0.45 to 0.65%, Si: 0.10 to 1.0%, Mn: 0.1 to 1.0%, P: 0.050% or less, S: 0.010% or less, Sol. Al:: 0.01 to 0.1%, N: 0.01% or less, Cr: 0.1 to 2.5%, Mo: 0.25 to 5.0%, Co: 0.05 to 5.0%, Cu: 0 to 0.50%, Ni: 0 to 0.50%, Ti: 0 to 0.030%, Nb: 0 to 0.15%, V: 0 to 0.5%, B: 0 to 0.003%, Ca: 0 to 0.004%, Mg: 0 to 0.004%, Zr: 0 to 0.004%, and rare earth metal: 0 to 0.004%, with a balance being Fe and impurities, and satisfying expressions and, wherein the microstructure comprises, by volume ratio, 90% or more of tempered martensite: C + Mn / 6 + Cr + Mo + V / 5 + Cu + Ni / 15 − Co / 6 + α ≥ 0.70 3 C + Mo + 3 Co / 3 Mn + Cr ≥ 1.0 Effective B = B − 11 N − Ti / 3.4 / 14 where, α in expression is 0.250 when effective B, by mass%, defined by expression is 0.0003% or more, and is 0 when the effective B is less than 0.0003%, where, a content, by mass%, of a corresponding element is substituted for each symbol of an element in expression to expression. C: more than 0.45 to 0.65%, Si: 0.10 to 1.0%, Mn: 0.1 to 1.0%, P: 0.050% or less, S: 0.010% or less, Sol. Al:: 0.01 to 0.1%, N: 0.01% or less, Cr: 0.1 to 2.5%, Mo: 0.25 to 5.0%, Co: 0.05 to 5.0%, Cu: 0 to 0.50%, Ni: 0 to 0.50%, Ti: 0 to 0.030%, Nb: 0 to 0.15%, V: 0 to 0.5%, B: 0 to 0.003%, Ca: 0 to 0.004%, Mg: 0 to 0.004%, Zr: 0 to 0.004%, and rare earth metal: 0 to 0.004%, with a balance being Fe and impurities, and satisfying expressions and, wherein the microstructure comprises, by volume ratio, 90% or more of tempered martensite: C + Mn / 6 + Cr + Mo + V / 5 + Cu + Ni / 15 − Co / 6 + α ≥ 0.70 3 C + Mo + 3 Co / 3 Mn + Cr ≥ 1.0 Effective B = B − 11 N − Ti / 3.4 / 14 where, α in expression is 0.250 when effective B, by mass%, defined by expression is 0.0003% or more, and is 0 when the effective B is less than 0.0003%, where, a content, by mass%, of a corresponding element is substituted for each symbol of an element in expression to expression.
Sawing machine comprising a plurality of saw blades, which are arranged in parallel planes, are adjustable relative to one another and can be driven in a rotatable manner, for sawing elongate workpieces consisting of wood, such as boards and/or pattern blocks, which workpieces are adjustable relative to the rotating saw blades in their longitudinal direction by means of a feed drive, wherein the sawing machine comprises at least two slides which face one another at the same height relative to the feed direction and have drive shafts, arranged coaxially with respect to one another, for the parallel saw blades, these slides are adjustable relative to one another transverse to the feed direction, and arranged on each slide is at least one rotatably driven drive shaft which is connected thereto and supports at least one saw blade, wherein arranged in each case above or below one of the slides is a further slide having a drive shaft and the respectively higher slide is mounted so as to be adjustable downwards and upwards, and wherein the saw blades of an upper and a lower slide are adjustable in parallel with one another and in each case in a corresponding plane and are slightly offset in the feed direction with their centre axes and are adjustable with their cutting edges in the feed direction in an overlapping manner one behind the other or laterally with respect to one another, characterised in that the rotatably driven drive shafts are formed on the slides as a hollow shaft, that mounted in the interior of these hollow shafts is a coaxial second shaft for at least one second parallel saw blade, which second shaft protrudes on the end side beyond said hollow shaft and is connected thereto for conjoint rotation but is adjustable together with a saw blade in the longitudinal direction, and that the lower slides are also adjustable in the vertical direction in addition to their horizontal adjustability.
A transport refrigeration system comprising: a natural gas engine; a compressed natural gas storage tank, characterized by further comprising: an artificial aspiration device providing decompressed natural gas and compressed air to the natural gas engine, the artificial aspiration device comprising: a turbine assembly comprising a turbine housing, at least one turbine enclosed within the turbine housing, a compressed natural gas inlet in the turbine housing and a decompressed natural gas outlet in the turbine housing; a compressor assembly comprising a compressor housing, at least one compressor enclosed within the compressor housing, an air inlet in the compressor housing and a hot compressed air outlet in the compressor housing; and a drive system mechanically connecting the at least one turbine to the at least one compressor; an electric generation device powered by the natural gas engine and providing an electric output; and a refrigeration unit electrically powered by the electric output of the electric generation device. a natural gas engine; a compressed natural gas storage tank, characterized by further comprising: an artificial aspiration device providing decompressed natural gas and compressed air to the natural gas engine, the artificial aspiration device comprising: a turbine assembly comprising a turbine housing, at least one turbine enclosed within the turbine housing, a compressed natural gas inlet in the turbine housing and a decompressed natural gas outlet in the turbine housing; a compressor assembly comprising a compressor housing, at least one compressor enclosed within the compressor housing, an air inlet in the compressor housing and a hot compressed air outlet in the compressor housing; and a drive system mechanically connecting the at least one turbine to the at least one compressor; a turbine assembly comprising a turbine housing, at least one turbine enclosed within the turbine housing, a compressed natural gas inlet in the turbine housing and a decompressed natural gas outlet in the turbine housing; a compressor assembly comprising a compressor housing, at least one compressor enclosed within the compressor housing, an air inlet in the compressor housing and a hot compressed air outlet in the compressor housing; and a drive system mechanically connecting the at least one turbine to the at least one compressor; an electric generation device powered by the natural gas engine and providing an electric output; and a refrigeration unit electrically powered by the electric output of the electric generation device.
A method of selectively encrypting digital video content, comprising; receiving a plurality of packets containing the digital video content; identifying packets containing start of frame headers; selecting certain of the packets for encryption according to a selection criterion, wherein the selected packets exclude the packets containing SOF headers; encrypting the selected packets; and retaining the packets containing the SOF headers unencrypted to form selectively encrypted digital video content, characterised by inserting padding into the packets containing SOF headers to move the information which is desired to be protected of the packets containing the SOF headers to different packets.
A pressure sensor configuration, comprising: a pressure sensor; a switchable valve coupled to the pressure sensor, the switchable valve enabling the pressure sensor to measure pressure at multiple ports of a pressurized tank; and a controller in communication with the pressure sensor, wherein the controller is configured to receive pressure measurements at the multiple ports from the pressure sensor and to calculate a differential pressure for the pressurized tank with the error in the differential pressure calculation cancelling out. a pressure sensor; a switchable valve coupled to the pressure sensor, the switchable valve enabling the pressure sensor to measure pressure at multiple ports of a pressurized tank; and a controller in communication with the pressure sensor, wherein the controller is configured to receive pressure measurements at the multiple ports from the pressure sensor and to calculate a differential pressure for the pressurized tank with the error in the differential pressure calculation cancelling out.