A system (2, 2') for particle beam therapy, comprising as seen in the flow direction of the particle beam: a) an adjustable gantry (10, 10') for the beam delivery to a target volume, i.e. malign tissue of a patient, said gantry (10, 10') comprising: a1) a beam coupling section for the incoming particle beam; said incoming particle beam being oriented substantially horizontally thereby defining a horizontal plane; a2) a first beam bending section (8, 8') comprising a number of beam deflection and/or focusing magnets (12, 14); said first bending section (8, 8') being adapted either to bend the particle beam with an adjustable angle into the vertical plane, or with 90 degrees in the horizontal plane, but with the mechanical possibility to rotate with an adjustable angle along the axis of the incoming particle beam; a3) a beam transport section adapted to receive the particle beam leaving the first beam bending section (8, 8') and to guide the particle beam to a second beam bending section; a4) the second beam bending section comprising a number of beam deflection magnets and/or beam focusing magnets; a5) a beam nozzle comprising a window for the exit of the particle beam; and b) a patient table/chair being rotatable and/or shiftable in the horizontal plane or in a plane being parallel to the horizontal plane and optionally being adjustable vertically, the system being characterised in that: c) the gantry (10, 10') is supported by a tilting mechanism allowing the gantry (10, 10') to be tilted vertically by an angle Φ 1, Φ 1 ε [-90°; +90°], wherein the gantry (10, 10') comprises a pivot (7, 7') being disposed in the region of the first beam bending section (8, 8'); and d) a rotation mechanism being disposed in a way that the second beam bending section and the beam nozzle are rotatable by an angle Φ 2, Φ 2 ε [-180°; +180°] around a direction given by the angle Φ 1. a) an adjustable gantry (10, 10') for the beam delivery to a target volume, i.e. malign tissue of a patient, said gantry (10, 10') comprising: a1) a beam coupling section for the incoming particle beam; said incoming particle beam being oriented substantially horizontally thereby defining a horizontal plane; a2) a first beam bending section (8, 8') comprising a number of beam deflection and/or focusing magnets (12, 14); said first bending section (8, 8') being adapted either to bend the particle beam with an adjustable angle into the vertical plane, or with 90 degrees in the horizontal plane, but with the mechanical possibility to rotate with an adjustable angle along the axis of the incoming particle beam; a3) a beam transport section adapted to receive the particle beam leaving the first beam bending section (8, 8') and to guide the particle beam to a second beam bending section; a4) the second beam bending section comprising a number of beam deflection magnets and/or beam focusing magnets; a5) a beam nozzle comprising a window for the exit of the particle beam; and a1) a beam coupling section for the incoming particle beam; said incoming particle beam being oriented substantially horizontally thereby defining a horizontal plane; a2) a first beam bending section (8, 8') comprising a number of beam deflection and/or focusing magnets (12, 14); said first bending section (8, 8') being adapted either to bend the particle beam with an adjustable angle into the vertical plane, or with 90 degrees in the horizontal plane, but with the mechanical possibility to rotate with an adjustable angle along the axis of the incoming particle beam; a3) a beam transport section adapted to receive the particle beam leaving the first beam bending section (8, 8') and to guide the particle beam to a second beam bending section; a4) the second beam bending section comprising a number of beam deflection magnets and/or beam focusing magnets; a5) a beam nozzle comprising a window for the exit of the particle beam; and b) a patient table/chair being rotatable and/or shiftable in the horizontal plane or in a plane being parallel to the horizontal plane and optionally being adjustable vertically, c) the gantry (10, 10') is supported by a tilting mechanism allowing the gantry (10, 10') to be tilted vertically by an angle Φ 1, Φ 1 ε [-90°; +90°], wherein the gantry (10, 10') comprises a pivot (7, 7') being disposed in the region of the first beam bending section (8, 8'); and d) a rotation mechanism being disposed in a way that the second beam bending section and the beam nozzle are rotatable by an angle Φ 2, Φ 2 ε [-180°; +180°] around a direction given by the angle Φ 1.