The compounds of Formula I or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W is wherein each R 4 is independently H, F, Cl, Br, I, OH, OCH 3, OCH 2 CH 3, SC alkyl, SOC (1.4) alkyl, SO 2 C alkyl, -C alkyl, -CO 2 R d CONR e R f, C=CR g, or CN; wherein R d is H, or -C alkyl; R e is H, or -C alkyl; R f is H, or -C alkyl; and R g is H, -CH 2 OH, or -CH 2 CH 2 OH; R 2 is cycloalkyl, spiro-substituted cycloalkenyl, piperidinyl, spirosubstituted piperidinyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, C alkyl, and C alkyl; or wherein R 2 is 4-(1'hydroxyeth-2'yl)piperidinyl; Z is H, F, or CH 3; J is CH, or N; X is or R 2 is H or -Q alkyl, wherein both R 2 may have either syn or anti stereochemistry; alternatively both R 2 in a syn relationship may be taken together to form -(CH 2) n -, where n is 2 or 3; R 3 is H, C alkyl, CH 2 CH 2 NH 2, CH 2 CH 2 OR a, -COCH 3, CONCH 2, or CO 2 R a; R 9 is H, C alkyl, OR 4, -NA 1 A 2, NA 1 SO 2 C alkyl, NA 1 COC alkyl,-NHCH 2 CH 2 OCH 2 CH 3, N(CH 2 CH 2 OH) 2, -N(CH 3)CH 2 CH 2 OCH 3, NHCH 2 CH 2 SO 2 CH 3, -NHCH 2 CON(CH 3) 2, or R 3 and R 9 may be taken together to form oxo, -OCH 2 CH 2 O-, or -OCH 2 C(R n) 2 CH 2 O-; R 10 is H, -C alkyl, -OR a, -CN, -NA 1 A 2, -SO 2 CH 3, -COOR a, -CO 2 CH 3, -CH 2 -NA 1 A 2,-CONA 1 A 2, -CH 2 OR a, -OC alkylOR a, -NHCH 2 CH 2 CO 2 R a,-NHCH 2 CH 2 OR a, -NR a CH 2 CH 2 NA 1 A 2,-OC alkylNA 1 A 2, -OCH 2 CO 2 R a,-CH 2 CO 2 R a, -CH 2 CH 2 SO 2 C alkyl, -SO 2 CH 2 CH 2 NA 1 A 2, SOCH 2 CH 2 NA 1 A 2,-SCH 2 CH 2 NA 1 A 2, -NHSO 2 CH 2 CH 2 MA 1 A 2, phenyl, imidazolyl, thiazolyl, 4H-[1,2,4]oxadiazol-5-onyl, 4H-pyrrolo[2,3-b]pyrazinyl, pyridinyl, [1,3,4]oxadiazolyl, 4H-[1,2,4]triazolyl, tetrazolyl, pyrazolyl, [1,3,5]triazinyl, and [1,3,4]thiadiazolyl; A 1 is H, -C alkyl, or CH 2 CH 2 OR a; A 2 is H, -C alkyl, COR a, CH 2 CON(CH 3) 2, -CH 2 CH 2 OR a, -CH 2 CH 2 SC alkyl, -CH 2 CH 2 SOC alkyl, or -CH 2 CH 2 SO 2 C alkyl; alternatively, A 1 and A 2 may be taken together with their attached nitrogen to form a heterocyclic ring selected from the following: wherein R a is H or C alkyl; R aa is H or C alkyl; and R bb is H, -C alkyl, -CH 2 CH 2 OCH 2 CH 2 OCH 3, -CH 2 CO 2 H,-C C alkly, or -CH 2 C C alkyl,. wherein cycloalkyl is a saturated or partially unsaturated ring composed of from 3 to 8 carbon atoms; and wherein spiro-substituted cycloalkenyl is a pair of cycloalkyl rings that share a single carbon atom and at least one of the rings is partially unsaturated; and wherein spiro-substituted piperidinyl is a piperidinyl and a cycloalkyl ring that share a single carbon atom W is wherein each R 4 is independently H, F, Cl, Br, I, OH, OCH 3, OCH 2 CH 3, SC alkyl, SOC (1.4) alkyl, SO 2 C alkyl, -C alkyl, -CO 2 R d CONR e R f, C=CR g, or CN; wherein R d is H, or -C alkyl; R e is H, or -C alkyl; R f is H, or -C alkyl; and R g is H, -CH 2 OH, or -CH 2 CH 2 OH; R 2 is cycloalkyl, spiro-substituted cycloalkenyl, piperidinyl, spirosubstituted piperidinyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl, or dihydropyranyl, any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, C alkyl, and C alkyl; or wherein R 2 is 4-(1'hydroxyeth-2'yl)piperidinyl; Z is H, F, or CH 3; J is CH, or N; X is or R 2 is H or -Q alkyl, wherein both R 2 may have either syn or anti stereochemistry; alternatively both R 2 in a syn relationship may be taken together to form -(CH 2) n -, where n is 2 or 3; R 3 is H, C alkyl, CH 2 CH 2 NH 2, CH 2 CH 2 OR a, -COCH 3, CONCH 2, or CO 2 R a; R 9 is H, C alkyl, OR 4, -NA 1 A 2, NA 1 SO 2 C alkyl, NA 1 COC alkyl,-NHCH 2 CH 2 OCH 2 CH 3, N(CH 2 CH 2 OH) 2, -N(CH 3)CH 2 CH 2 OCH 3, NHCH 2 CH 2 SO 2 CH 3, -NHCH 2 CON(CH 3) 2, or R 3 and R 9 may be taken together to form oxo, -OCH 2 CH 2 O-, or -OCH 2 C(R n) 2 CH 2 O-; R 10 is H, -C alkyl, -OR a, -CN, -NA 1 A 2, -SO 2 CH 3, -COOR a, -CO 2 CH 3, -CH 2 -NA 1 A 2,-CONA 1 A 2, -CH 2 OR a, -OC alkylOR a, -NHCH 2 CH 2 CO 2 R a,-NHCH 2 CH 2 OR a, -NR a CH 2 CH 2 NA 1 A 2,-OC alkylNA 1 A 2, -OCH 2 CO 2 R a,-CH 2 CO 2 R a, -CH 2 CH 2 SO 2 C alkyl, -SO 2 CH 2 CH 2 NA 1 A 2, SOCH 2 CH 2 NA 1 A 2,-SCH 2 CH 2 NA 1 A 2, -NHSO 2 CH 2 CH 2 MA 1 A 2, phenyl, imidazolyl, thiazolyl, 4H-[1,2,4]oxadiazol-5-onyl, 4H-pyrrolo[2,3-b]pyrazinyl, pyridinyl, [1,3,4]oxadiazolyl, 4H-[1,2,4]triazolyl, tetrazolyl, pyrazolyl, [1,3,5]triazinyl, and [1,3,4]thiadiazolyl; A 1 is H, -C alkyl, or CH 2 CH 2 OR a; A 2 is H, -C alkyl, COR a, CH 2 CON(CH 3) 2, -CH 2 CH 2 OR a, -CH 2 CH 2 SC alkyl, -CH 2 CH 2 SOC alkyl, or -CH 2 CH 2 SO 2 C alkyl; alternatively, A 1 and A 2 may be taken together with their attached nitrogen to form a heterocyclic ring selected from the following: wherein R a is H or C alkyl; R aa is H or C alkyl; and R bb is H, -C alkyl, -CH 2 CH 2 OCH 2 CH 2 OCH 3, -CH 2 CO 2 H,-C C alkly, or -CH 2 C C alkyl,.