A compound having formula I or pharmaceutically acceptable salts, hydrates, N-oxides, isotopically enriched or an enantiomerically enriched versions thereof, wherein the subscript n is an integer of from 0 to 2; each R 1, when present, is independently selected from the group consisting of C 1-4 alkyl, -CO 2 R a, -X-CO 2 R a, -CONR a R b and -X-CONR a R b; R 2 and R 3 are each members independently selected from the group consisting of H, -R a, -XR a, -XNR a R b, -XNHCONR a R b, -XNHCOR a, -X-O-CONR a R b, -XNHSO 2 R a, -CO 2 R a, -X-CO 2 R a, -CONR a R b and -X-CONR a R b; or taken together are oxo; C 1 is selected from the group consisting of phenyl, optionally substituted with from 1 to 3 R 4 substituents; pyridyl, optionally substituted with from 1 to 3 R 4 substituents; naphthyl, optionally substituted with from 1 to 3 R 4 substituents; and a fused-bicyclic heteroaryl, wherein the fused-bicyclic heteroaryl is selected from the group consisting of quinolinyl and benzopyrazolyl, optionally substituted with from 1 to 3 R 4 substituents; C 2 is monocyclic four-, five-, six- or seven-membered ring selected from the group consisting of benzene, heteroaromatic, cycloalkane, and heterocycloalkane, wherein the heteroaromatic and heterocycloalkane rings have from 1-3 heteroatoms as ring members selected from N, O and S; and wherein each of said monocyclic C 2 rings are optionally substituted with from 1 to 3 R 5 substituents; C 3 is selected from the group consisting of hydrogen, C 1-8 alkyl, C 3-8 cycloalkyl, aryl, aryl-C 1-4 alkyl, heteroaryl, heteroaryl-C 1-4 alkyl, and four- to six-membered heterocycloalkyl, wherein the heterocycloalkyl group or portion has from 1-3 heteroatoms selected from N, O and S, and wherein the heteroaryl group has from 1-3 heteroatoms as ring members selected from N, O and S, and each C 3 is optionally substituted with from 1-3 R 6 substituents; each R 4 is independently selected from the group consisting of halogen, -CN, -NO 2, -R c, -CO 2R a, -NR a R b, -OR a, -X-CO 2 R a, -CONR a R b and -X-CONR a R b; wherein within each of R 1, R 2, R 3 and R 4, each R a and R b is independently selected from hydrogen, C 1-8 alkyl, C 3-7 cycloalkyl, C 1-8 haloalkyl, and four- to six-membered heterocycloalkyl, or when attached to the same nitrogen atom can be combined with the nitrogen atom to form a four-, five- or six-membered ring having from 0 to 2 additional heteroatoms as ring members selected from N, O or S; each R c is independently selected from the group consisting of C 1-8 alkyl, C 1-8 haloalkyl, C 3-6 cycloalkyl, aryl and heteroaryl, and wherein the aliphatic and cyclic portions of R a, R b and R c are optionally further substituted with from one to three halogen, hydroxy, methyl, alkoxy, amino, alkyl-amino, dialkylamino, carboxamide, carboxy alkyl ester, carboxylic acid, heteroaryl, and four- to six-membered heterocycloalkyl groups; and wherein the heterocycloalkyl portions of R 2, R 3 and R 4 are optionally substituted with oxo; and optionally when two R 4 substituents are on adjacent atoms, are combined to form a fused five or six-membered ring having carbon and oxygen atoms as ring members; each R 5 is independently selected from the group consisting of halogen, -CN, -NO 2, -R f, -CO 2 R d, -COR d, -NR d R e, -OR d, -X-CO 2 R d, -CONR d R e and -X-CONR d R e; wherein each R d and R e is independently selected from hydrogen, C 1-8 alkyl, C 1-8 haloalkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylalkyl, and four- to six-membered heterocycloalkyl or when attached to the same nitrogen atom can be combined with the nitrogen atom to form a five or six-membered ring having from 0 to 2 additional heteroatoms as ring members selected from N, O or S; each R f is independently selected from the group consisting of C 1-8 alkyl, C 1-8 haloalkyl, and C 3-6 cycloalkyl, and wherein the aliphatic and cyclic portions of R d, R e and R f are optionally further substituted with from one to three halogen, hydroxy, methyl, alkoxy, amino, alkylamino, dialkylamino, carboxamide, carboxy alkyl ester, carboxylic acid, heteroaryl, four- to six-membered heterocycloalkyl groups; each R 6 is independently selected from the group consisting of halogen, -CN, -NO 2, -R i, -CO 2 R g, -COR g, -NR g R h, -OR g, -X-CO 2 R g, -X-COR g, -CONR g R h and -X-CONR g R h, wherein each R g and R h is independently selected from hydrogen, C 1-8 alkyl and C 1-8 haloalkyl; each R i is independently selected from the group consisting of C 1-8 alkyl and C 1-8 haloalkyl; and each X is a C 1-4 alkylene linking group or a linking group having the formula -(CH 2) m O(CH 2) p -, wherein the subscripts m and p are integer of from 0 to 5, and m + p is from 0 to 6, wherein any of the methylene portions of X are optionally substituted with one or two methyl groups.