mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising: CRISPR complex components comprising: I. CRISPR-Cas system polynucleotide sequence(s) which comprise(s): (a) an engineered guide sequence comprised of RNA and capable of hybridizing to a target sequence in a polynucleotide locus, (b) a tracr mate sequence comprised of RNA, and (c) a tracrRNA sequence comprised of RNA, and wherein (a), (b) and (c) are arranged in a 5' to 3' orientation, II. a Type II Cas9 protein, wherein the tracr mate sequence hybridizes to the tracrRNA sequence and the guide sequence directs sequence-specific binding of a CRISPR complex to a target sequence, wherein the CRISPR complex comprises the Type II Cas9 protein complexed with the guide sequence that is hybridized to the target sequence, and the tracr mate sequence that is hybridized to the tracrRNA sequence, and wherein the Type II Cas9 protein is or comprises a Staphylococcus aureus Cas9 (SaCas9). CRISPR complex components comprising: I. CRISPR-Cas system polynucleotide sequence(s) which comprise(s): (a) an engineered guide sequence comprised of RNA and capable of hybridizing to a target sequence in a polynucleotide locus, (b) a tracr mate sequence comprised of RNA, and (c) a tracrRNA sequence comprised of RNA, and wherein (a), (b) and (c) are arranged in a 5' to 3' orientation, II. a Type II Cas9 protein, wherein the tracr mate sequence hybridizes to the tracrRNA sequence and the guide sequence directs sequence-specific binding of a CRISPR complex to a target sequence, wherein the CRISPR complex comprises the Type II Cas9 protein complexed with the guide sequence that is hybridized to the target sequence, and the tracr mate sequence that is hybridized to the tracrRNA sequence, and wherein the Type II Cas9 protein is or comprises a Staphylococcus aureus Cas9 (SaCas9). I. CRISPR-Cas system polynucleotide sequence(s) which comprise(s): (a) an engineered guide sequence comprised of RNA and capable of hybridizing to a target sequence in a polynucleotide locus, (b) a tracr mate sequence comprised of RNA, and (c) a tracrRNA sequence comprised of RNA, and wherein (a), (b) and (c) are arranged in a 5' to 3' orientation, (a) an engineered guide sequence comprised of RNA and capable of hybridizing to a target sequence in a polynucleotide locus, (b) a tracr mate sequence comprised of RNA, and (c) a tracrRNA sequence comprised of RNA, and wherein (a), (b) and (c) are arranged in a 5' to 3' orientation, II. a Type II Cas9 protein,
Threaded insert suitable for installation in a pipe portion through which a fluid flows, the threaded insert comprising: a hollow cylindrical main body (12; 112; 212; 312) having a first end portion (14; 114) and a second end portion (16; 116; 216; 316) and having an internal thread; a bearing head (18; 118; 218) on the first end portion (14; 114) of the main body (12; 112; 212; 312), which bearing head protrudes beyond the main body (12; 112; 212; 312) in the radial direction of the main body (12; 112; 212; 312); a fastening portion (20; 120; 220; 320), which is arranged on the main body (12; 112; 212; 312) at a predetermined distance from the bearing head (18; 118; 218) in the axial direction of the main body (12; 112; 212; 312) and protrudes beyond the main body (12; 112; 212; 312) in the radial direction; and a contact portion (22; 122; 222; 322), which is arranged and designed between the bearing head (18; 118; 218) and the fastening portion (20; 120; 220; 320) in the axial direction of the main body (12; 112; 212; 312) such that, in an installed state, a wall of a distributing pipe opening rests against said contact portion, characterised in that the main body (12; 112; 212; 312) has an oval or polygonal outer periphery at least in the region of the contact portion (22; 122; 222; 322). a hollow cylindrical main body (12; 112; 212; 312) having a first end portion (14; 114) and a second end portion (16; 116; 216; 316) and having an internal thread; a bearing head (18; 118; 218) on the first end portion (14; 114) of the main body (12; 112; 212; 312), which bearing head protrudes beyond the main body (12; 112; 212; 312) in the radial direction of the main body (12; 112; 212; 312); a fastening portion (20; 120; 220; 320), which is arranged on the main body (12; 112; 212; 312) at a predetermined distance from the bearing head (18; 118; 218) in the axial direction of the main body (12; 112; 212; 312) and protrudes beyond the main body (12; 112; 212; 312) in the radial direction; and a contact portion (22; 122; 222; 322), which is arranged and designed between the bearing head (18; 118; 218) and the fastening portion (20; 120; 220; 320) in the axial direction of the main body (12; 112; 212; 312) such that, in an installed state, a wall of a distributing pipe opening rests against said contact portion, characterised in that the main body (12; 112; 212; 312) has an oval or polygonal outer periphery at least in the region of the contact portion (22; 122; 222; 322).
A method for compressing and sizing a sintered body obtained by sintering a compact of a metal powder to densify a surface of the sintered body, comprising the following steps: Providing a sizing die comprising: a die member (3, 4) for densifying the surface of the sintered body, said die member (3, 4) having: a taper portion (12, 22) provided on an upper portion (13, 13A, 23, 23A) of said die member (3, 4); and a straight portion provided on a lower portion (14, 24) of said die member (3, 4), wherein at least an upper portion (15, 25) of the taper portion (12, 22) is made of a material having a Young's modulus that is higher than the Young's modulus of a material of said lower portion (14, 24) of said die member (3, 4), and is at least 50 GPa higher than the Young's modulus of said sintered body that has not yet been sized; Inserting the sintered body from the taper portion (12, 22) toward the straight portion (11, 21) to size the sintered body; and Compressing the sintered body vertically at the straight portion (11, 21) by upper and lower punches (6, 5) to densify the surface of the sintered body. a die member (3, 4) for densifying the surface of the sintered body, said die member (3, 4) having: a taper portion (12, 22) provided on an upper portion (13, 13A, 23, 23A) of said die member (3, 4); and a straight portion provided on a lower portion (14, 24) of said die member (3, 4), wherein a taper portion (12, 22) provided on an upper portion (13, 13A, 23, 23A) of said die member (3, 4); and a straight portion provided on a lower portion (14, 24) of said die member (3, 4), wherein at least an upper portion (15, 25) of the taper portion (12, 22) is made of a material having a Young's modulus that is higher than the Young's modulus of a material of said lower portion (14, 24) of said die member (3, 4), and is at least 50 GPa higher than the Young's modulus of said sintered body that has not yet been sized; Inserting the sintered body from the taper portion (12, 22) toward the straight portion (11, 21) to size the sintered body; and Compressing the sintered body vertically at the straight portion (11, 21) by upper and lower punches (6, 5) to densify the surface of the sintered body.
An airfoil for a gas turbine engine, the airfoil comprising: a cooling channel extending generally radially through the airfoil; an impingement cavity disposed adjacent the cooling channel and at least partially bounded by an interior surface of a leading edge of the airfoil; and an airfoil structure bounding the cooling channel; characterised in that: the airfoil structure defines a cooling passage therethrough for directing a cooling medium into the impingement cavity to impinge on the interior surface of the leading edge; and the airfoil further comprises a swirl structure operatively associated with the cooling passage and configured to impart tangential velocity to the cooling medium. a cooling channel extending generally radially through the airfoil; an impingement cavity disposed adjacent the cooling channel and at least partially bounded by an interior surface of a leading edge of the airfoil; and an airfoil structure bounding the cooling channel; characterised in that: the airfoil structure defines a cooling passage therethrough for directing a cooling medium into the impingement cavity to impinge on the interior surface of the leading edge; and the airfoil further comprises a swirl structure operatively associated with the cooling passage and configured to impart tangential velocity to the cooling medium. the airfoil structure defines a cooling passage therethrough for directing a cooling medium into the impingement cavity to impinge on the interior surface of the leading edge; and the airfoil further comprises a swirl structure operatively associated with the cooling passage and configured to impart tangential velocity to the cooling medium.
A fluid circulation device for circulating a fluid comprising a structure body which comprises: a plural number of micro-channels extended in a direction, and at the same time, arranged so as to be lined up in a direction intersecting the direction, each for circulating the fluid; and at least one communicating part (30, 75, 76, 78, 79, 80) for linking micro-channels adjacent to each other in an arrangement direction of the plural number of micro-channels to each other, to allow communicating with each other; formed inside of the structure body, characterized in that the communicating part (30, 75, 76, 78, 79, 80) has a width (Wi) equal to or less than a flow passage width (Wa) of the micro-channel. a plural number of micro-channels extended in a direction, and at the same time, arranged so as to be lined up in a direction intersecting the direction, each for circulating the fluid; and at least one communicating part (30, 75, 76, 78, 79, 80) for linking micro-channels adjacent to each other in an arrangement direction of the plural number of micro-channels to each other, to allow communicating with each other; formed inside of the structure body, characterized in that the communicating part (30, 75, 76, 78, 79, 80) has a width (Wi) equal to or less than a flow passage width (Wa) of the micro-channel.
Method for revamping a reforming section of a chemical plant in which: the reforming section receives a first stream of a hydrocarbon feed and steam and converts it into at least partially reformed gas, the plant comprises at least one apparatus operated as heater or evaporator of a fluid and comprising a shell and first heat exchange bodies, wherein said apparatus is heated with at least partially reformed hot gas coming from the reforming section and fed to the shell side, and said fluid is heated and/or evaporated inside said first heat exchange bodies by means of indirect heat exchange with said hot gas, the method comprising: modifying said apparatus by replacing said first heat exchange bodies with second heat exchange bodies containing a reforming catalyst, providing a hydrocarbon feed line arranged to direct a second stream of a hydrocarbon feed inside said second heat exchange bodies, and providing a line arranged to withdraw an at least partially reformed gas stream from said second heat exchange bodies, the apparatus thus being converted into a gas heated reformer. the reforming section receives a first stream of a hydrocarbon feed and steam and converts it into at least partially reformed gas, the plant comprises at least one apparatus operated as heater or evaporator of a fluid and comprising a shell and first heat exchange bodies, wherein said apparatus is heated with at least partially reformed hot gas coming from the reforming section and fed to the shell side, and said fluid is heated and/or evaporated inside said first heat exchange bodies by means of indirect heat exchange with said hot gas, the method comprising: modifying said apparatus by replacing said first heat exchange bodies with second heat exchange bodies containing a reforming catalyst, providing a hydrocarbon feed line arranged to direct a second stream of a hydrocarbon feed inside said second heat exchange bodies, and providing a line arranged to withdraw an at least partially reformed gas stream from said second heat exchange bodies, the apparatus thus being converted into a gas heated reformer. modifying said apparatus by replacing said first heat exchange bodies with second heat exchange bodies containing a reforming catalyst, providing a hydrocarbon feed line arranged to direct a second stream of a hydrocarbon feed inside said second heat exchange bodies, and providing a line arranged to withdraw an at least partially reformed gas stream from said second heat exchange bodies, the apparatus thus being converted into a gas heated reformer.
A loudspeaker, comprising: a speaker assembly having a central plane; and a plurality of drivers (305, 310a, 310b) at least three in number mounted on said speaker assembly in said central plane of said speaker assembly, each driver being associated with a magnet reaction force and with a moment based in part on its position relative to a center of mass of said speaker assembly the magnet reaction force of each driver being essentially perpendicular to said central plane of said speaker assembly; wherein said drivers are laterally mutually offset from one another relative to said center of mass of said speaker assembly, and the drivers are selectively driven by an audio signal in a manner such that the sum of the magnet reaction forces associated with all of the drivers is substantially equal to zero, and the sum of the moments associated with all of the drivers is substantially equal to zero to cancel vibrations of the loudspeaker. a speaker assembly having a central plane; and a plurality of drivers (305, 310a, 310b) at least three in number mounted on said speaker assembly in said central plane of said speaker assembly, each driver being associated with a magnet reaction force and with a moment based in part on its position relative to a center of mass of said speaker assembly the magnet reaction force of each driver being essentially perpendicular to said central plane of said speaker assembly; wherein said drivers are laterally mutually offset from one another relative to said center of mass of said speaker assembly, and the drivers are selectively driven by an audio signal in a manner such that the sum of the magnet reaction forces associated with all of the drivers is substantially equal to zero, and the sum of the moments associated with all of the drivers is substantially equal to zero to cancel vibrations of the loudspeaker.
An aircraft cabin floor structure comprising: a rigid carpet impermeable to air, the carpet having a carpet top face and a carpet bottom face; an adhesive layer having an adhesive top face and an adhesive bottom face, the adhesive top face adhering to the carpet bottom face; and a floor panel impermeable to air, the floor panel having a panel top face and a panel bottom face, the adhesive bottom face adhering to the panel top face, characterised in that the carpet bottom face includes grooves and comprises on its periphery at least one air evacuation channel; and the adhesive layer comprises a plurality of through holes. a rigid carpet impermeable to air, the carpet having a carpet top face and a carpet bottom face; an adhesive layer having an adhesive top face and an adhesive bottom face, the adhesive top face adhering to the carpet bottom face; and a floor panel impermeable to air, the floor panel having a panel top face and a panel bottom face, the adhesive bottom face adhering to the panel top face, characterised in that the carpet bottom face includes grooves and comprises on its periphery at least one air evacuation channel; and the adhesive layer comprises a plurality of through holes.
Method for producing a large component for a rail vehicle from light metal hollow profiles, having the following method steps: - arranging the light metal hollow profiles in a determined sequence, - joining the light metal hollow profiles to the respectively adjacent light metal hollow profiles by means of a welding method, characterized in that - a cover layer of the light metal hollow profiles is at least partially removed, wherein, in addition to the cover layer, webs within the light metal hollow profiles are also removed, wherein portions of webs remain underneath the removed regions of the cover layer. - arranging the light metal hollow profiles in a determined sequence, - joining the light metal hollow profiles to the respectively adjacent light metal hollow profiles by means of a welding method, - a cover layer of the light metal hollow profiles is at least partially removed, wherein, in addition to the cover layer, webs within the light metal hollow profiles are also removed, wherein portions of webs remain underneath the removed regions of the cover layer.
A straddled vehicle comprising: a head pipe; a steering device turnably supported by the head pipe; a side cover disposed lateral to the steering device and on one side of the head pipe in a vehicle width direction; a storage box disposed inside the side cover, the storage box including a storage portion and a lid portion, the storage portion including an opening for putting-in and taking-out of an item, the lid portion configured to open and close the storage portion; and an operating member for causing the lid portion to perform an opening action, the operating member being disposed apart from the side cover on the one side of the head pipe in the vehicle width direction and on an inner side of the storage box in the vehicle width direction; said operating member being accessible from a space between the steering device and the side cover; characterized in that said operating member is disposed on an external surface of a vehicle width directionally inner portion of the storage box. a head pipe; a steering device turnably supported by the head pipe; a side cover disposed lateral to the steering device and on one side of the head pipe in a vehicle width direction; a storage box disposed inside the side cover, the storage box including a storage portion and a lid portion, the storage portion including an opening for putting-in and taking-out of an item, the lid portion configured to open and close the storage portion; and an operating member for causing the lid portion to perform an opening action, the operating member being disposed apart from the side cover on the one side of the head pipe in the vehicle width direction and on an inner side of the storage box in the vehicle width direction; said operating member being accessible from a space between the steering device and the side cover; characterized in that said operating member is disposed on an external surface of a vehicle width directionally inner portion of the storage box.
A cartridge assembly for use in an electronic nicotine delivery system comprising: a) a body assembly having an interior surface defining an interior volume, the interior volume including a reservoir, the reservoir having a top wall with an opening formed therein, a sealing element, and side walls having an inner surface and an outer surface, the interior surface of side walls defining an interior volume of the reservoir; b) a port formed in the sealing element of the reservoir to allow insertion of a wick therethrough from the electronic nicotine delivery system; c) at least one conduit formed between the outer surface of sidewalls of the reservoir and the interior surface of the body assembly, the at least one conduit having at least one open top end, at least one open bottom end, and being configured for conducting aerosolized nicotine; and d) a manifold for holding and distributing aerosolized nicotine, the manifold positioned above the top wall of the reservoir, the manifold having an open top end and at least one open bottom end, and at least one interior channel connecting the open top end with the at least one open bottom end, wherein the at least one open bottom end is secured onto the at least one open top end of the at least one conduit and is in fluid communication with the at least one conduit. a) a body assembly having an interior surface defining an interior volume, the interior volume including a reservoir, the reservoir having a top wall with an opening formed therein, a sealing element, and side walls having an inner surface and an outer surface, the interior surface of side walls defining an interior volume of the reservoir; b) a port formed in the sealing element of the reservoir to allow insertion of a wick therethrough from the electronic nicotine delivery system; c) at least one conduit formed between the outer surface of sidewalls of the reservoir and the interior surface of the body assembly, the at least one conduit having at least one open top end, at least one open bottom end, and being configured for conducting aerosolized nicotine; and d) a manifold for holding and distributing aerosolized nicotine, the manifold positioned above the top wall of the reservoir, the manifold having an open top end and at least one open bottom end, and at least one interior channel connecting the open top end with the at least one open bottom end, wherein the at least one open bottom end is secured onto the at least one open top end of the at least one conduit and is in fluid communication with the at least one conduit.
A vehicle controller, comprising: a control unit configured to control, in accordance with a transportation plan, a vehicle to autonomously move to a position of a checkpoint at an entrance to a target highway port which is provided along a highway for dispatching and storing goods, and interact with a checkpoint controller corresponding to the position of the checkpoint for autonomously passing the checkpoint; and control the vehicle to autonomously move from the position of the checkpoint to a specified loading/unloading position in the target highway port, and interact with a loading/unloading control apparatus for autonomous loading/unloading at the loading/unloading position, characterized in that the control unit being configured to control the vehicle to autonomously move to the position of the checkpoint at the entrance to the target highway port comprises: the control unit being configured to plan a route from a current position to the position of the checkpoint, control the vehicle to autonomously move along the route, and control the vehicle to stop in response to determining from an image or point cloud data transmitted by a vehicle-mounted sensor that an obstacle in the front is a checkpoint and a distance from the vehicle to the checkpoint is smaller than or equal to a distance threshold. a control unit configured to control, in accordance with a transportation plan, a vehicle to autonomously move to a position of a checkpoint at an entrance to a target highway port which is provided along a highway for dispatching and storing goods, and interact with a checkpoint controller corresponding to the position of the checkpoint for autonomously passing the checkpoint; and control the vehicle to autonomously move from the position of the checkpoint to a specified loading/unloading position in the target highway port, and interact with a loading/unloading control apparatus for autonomous loading/unloading at the loading/unloading position, characterized in that the control unit being configured to control the vehicle to autonomously move to the position of the checkpoint at the entrance to the target highway port comprises: the control unit being configured to plan a route from a current position to the position of the checkpoint, control the vehicle to autonomously move along the route, and control the vehicle to stop in response to determining from an image or point cloud data transmitted by a vehicle-mounted sensor that an obstacle in the front is a checkpoint and a distance from the vehicle to the checkpoint is smaller than or equal to a distance threshold.