A biopsy device, comprising: a chamber housing having a proximal chamber, a transition chamber, and a distal chamber that form a continuous passage in the chamber housing, and having a longitudinal axis along which the proximal chamber, the transition chamber, and the distal chamber are arranged, the proximal chamber having a first cylindrical side wall that has a first proximal end and a first distal end, the transition chamber having a frustoconical side wall that has a base end and a narrowed end, and the distal chamber having a second cylindrical side wall that has a second proximal end and a second distal end, the base end of the frustoconical side wall being joined to the first distal end of the first cylindrical side wall and the narrowed end of the frustoconical side wall being joined to the second proximal end of the second cylindrical side wall, such that the first cylindrical side wall, the frustoconical side wall, and the second cylindrical side wall form a continuous interior surface of the chamber housing; a drive piston located in the proximal chamber; a drive source connected to the drive piston, the drive source configured to move the drive piston in the proximal chamber along the longitudinal axis; a driven piston located in the distal chamber, the driven piston configured to move in the distal chamber along the longitudinal axis; a cavity defined in the chamber housing between the drive piston and the driven piston; a hydraulic fluid of a fixed quantity that fills the cavity between the drive piston and the driven piston, forming a hydraulic connection between the drive piston and the driven piston, such that a displacement of the drive piston along the longitudinal axis results in an amplified displacement of the driven piston along the longitudinal axis; and an elongate biopsy member connected to the driven piston. a chamber housing having a proximal chamber, a transition chamber, and a distal chamber that form a continuous passage in the chamber housing, and having a longitudinal axis along which the proximal chamber, the transition chamber, and the distal chamber are arranged, the proximal chamber having a first cylindrical side wall that has a first proximal end and a first distal end, the transition chamber having a frustoconical side wall that has a base end and a narrowed end, and the distal chamber having a second cylindrical side wall that has a second proximal end and a second distal end, the base end of the frustoconical side wall being joined to the first distal end of the first cylindrical side wall and the narrowed end of the frustoconical side wall being joined to the second proximal end of the second cylindrical side wall, such that the first cylindrical side wall, the frustoconical side wall, and the second cylindrical side wall form a continuous interior surface of the chamber housing; a drive piston located in the proximal chamber; a drive source connected to the drive piston, the drive source configured to move the drive piston in the proximal chamber along the longitudinal axis; a driven piston located in the distal chamber, the driven piston configured to move in the distal chamber along the longitudinal axis; a cavity defined in the chamber housing between the drive piston and the driven piston; a hydraulic fluid of a fixed quantity that fills the cavity between the drive piston and the driven piston, forming a hydraulic connection between the drive piston and the driven piston, such that a displacement of the drive piston along the longitudinal axis results in an amplified displacement of the driven piston along the longitudinal axis; and an elongate biopsy member connected to the driven piston.