A compound of Formula: or a stereoisomer, a geometric isomer, a tautomer, an N -oxide, a solvate or a pharmaceutically salt thereof, wherein: each of W 1, W 2 and W 3 is independently N or CR c; Z is CN; Y is (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 6 -C 10)aryl or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 6 -C 10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N 3, OR a, SR a, NR a R b, -C(=O)NR a R b, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, -(C 1 -C 4)alkylene-CN, -(C 1 -C 4)alkylene-OR a, -(C 1 -C 4)alkylene-NR a R b, (C 6 -C 10)aryl and 5-10 membered heteroaryl; R 1 is OR a; each R a and R b is independently H or (C 1 -C 6)alkyl, wherein the (C 1 -C 6)alkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)alkoxy, and (C 1 -C 6)alkylamino; and each R c is independently H, D, F, Cl, Br, I, N 3, CN, OH, NH 2, (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkylamino, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkylamino, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy and (C 1 -C 6)alkylamino. each of W 1, W 2 and W 3 is independently N or CR c; Z is CN; Y is (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 6 -C 10)aryl or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 6 -C 10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N 3, OR a, SR a, NR a R b, -C(=O)NR a R b, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, -(C 1 -C 4)alkylene-CN, -(C 1 -C 4)alkylene-OR a, -(C 1 -C 4)alkylene-NR a R b, (C 6 -C 10)aryl and 5-10 membered heteroaryl; R 1 is OR a; each R a and R b is independently H or (C 1 -C 6)alkyl, wherein the (C 1 -C 6)alkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)alkoxy, and (C 1 -C 6)alkylamino; and each R c is independently H, D, F, Cl, Br, I, N 3, CN, OH, NH 2, (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkylamino, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkylamino, (C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy and (C 1 -C 6)alkylamino.