mhurhangee/ep-ind-claims huggingface dataset:
Use of a polyfunctional compound of the Formula I: wherein: A is a low molecular weight scaffold selected from the group consisting of functionalized monocyclic and polycyclic hydrocarbons, functionalized monocyclic and polycyclic heterocycles, an amino acid residue, linear peptides, cyclic peptides, synthetic peptides, semisynthetic peptides, peptidomimetics and hyaluronic acid; each L 1, L 2 and L 3 is independently a bond, a linker selected from the group consisting of an amino acid residue, -O-, -S-, -S -, -S 2 -, -NR a -, C 1-6 alkyl, and-(CH 2 CH 2 O) 1-15, wherein R a is H, C 1-5 alkyl, heterocyclyl, aryl, or heteroaryl, and wherein 1 or 2 carbon atoms of the C 1-6 alkyl are optionally replaced by a -O-, -C -, -C NR'-, -S-, -S -, -S 2 -, -S 2 NR'- or -NR'- wherein R' is H or C 1-5 alkyl, and wherein the C 1-6 alkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of-OH, -SH, -NH 2, heterocyclyl, aryl and heteroaryl; V is -N 3 or C 2 -C 4 alkynyl; X is an activated moiety of a carboxyl group; Y is electrophilic group; each of m, n and p is independently an integer of 1 to 10; or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof, in the preparation of a compound of any one of claims 7-12 or 13-17. A is a low molecular weight scaffold selected from the group consisting of functionalized monocyclic and polycyclic hydrocarbons, functionalized monocyclic and polycyclic heterocycles, an amino acid residue, linear peptides, cyclic peptides, synthetic peptides, semisynthetic peptides, peptidomimetics and hyaluronic acid; each L 1, L 2 and L 3 is independently a bond, a linker selected from the group consisting of an amino acid residue, -O-, -S-, -S -, -S 2 -, -NR a -, C 1-6 alkyl, and-(CH 2 CH 2 O) 1-15, wherein R a is H, C 1-5 alkyl, heterocyclyl, aryl, or heteroaryl, and wherein 1 or 2 carbon atoms of the C 1-6 alkyl are optionally replaced by a -O-, -C -, -C NR'-, -S-, -S -, -S 2 -, -S 2 NR'- or -NR'- wherein R' is H or C 1-5 alkyl, and wherein the C 1-6 alkyl is optionally substituted with 1 or 2 substituents selected from the group consisting of-OH, -SH, -NH 2, heterocyclyl, aryl and heteroaryl; V is -N 3 or C 2 -C 4 alkynyl; X is an activated moiety of a carboxyl group; Y is electrophilic group; each of m, n and p is independently an integer of 1 to 10; or a pharmaceutically acceptable salt thereof, optionally in the form of a single stereoisomer or mixtures of stereoisomers thereof, in the preparation of a compound of any one of claims 7-12 or 13-17.
An image recording apparatus comprising: a laser emitting device configured to emit laser beams emitted from a plurality of laser light-emitting elements; an optical fiber array including a plurality of optical fibers provided corresponding to the laser light-emitting elements and configured to guide the laser beams emitted from the laser light-emitting elements to a recording object that relatively moves with respect to the laser emitting device, laser emitting portions of the respective optical fibers being arrayed in an array form in a predetermined direction; an image recording unit configured to control the laser emitting device so as to irradiate the recording object which relatively moves with respect to the laser emitting device in a direction different from the predetermined direction, with laser beams via the optical fiber array, to heat the recording object and record an image; and characterized by an amplitude measurement unit configured to measure amplitude of vibration in a direction orthogonal to a conveying direction of the recording-object conveying unit, wherein the image recording unit is configured to record an image on the recording object, based on a measurement result of the amplitude measurement unit, wherein the image recording unit is configured to record the image on the recording object while amplitude of vibration of the recording object is equal to or less than a threshold. a laser emitting device configured to emit laser beams emitted from a plurality of laser light-emitting elements; an optical fiber array including a plurality of optical fibers provided corresponding to the laser light-emitting elements and configured to guide the laser beams emitted from the laser light-emitting elements to a recording object that relatively moves with respect to the laser emitting device, laser emitting portions of the respective optical fibers being arrayed in an array form in a predetermined direction; an image recording unit configured to control the laser emitting device so as to irradiate the recording object which relatively moves with respect to the laser emitting device in a direction different from the predetermined direction, with laser beams via the optical fiber array, to heat the recording object and record an image; and characterized by an amplitude measurement unit configured to measure amplitude of vibration in a direction orthogonal to a conveying direction of the recording-object conveying unit, wherein the image recording unit is configured to record an image on the recording object, based on a measurement result of the amplitude measurement unit, wherein the image recording unit is configured to record the image on the recording object while amplitude of vibration of the recording object is equal to or less than a threshold.
A valve body for pumps, comprising: a compressed air-filled chamber in a center of the valve body; a compressed air supply port through which compressed air is supplied into said compressed air-filled chamber; a first side wall joined to a first air chamber block that defines a first air chamber and that has at least one first through-hole; a first communication passage communicating between said compressed air-filled chamber and said first side wall; an annular groove-shaped first air supply chamber formed in said first side wall, said first communication passage and said at least one first through-hole being communicated with each other through said annular groove-shaped first air supply chamber; and an annular groove-shaped second air supply chamber; characterized in that a second side wall is joined to a second air chamber block that defines a second air chamber and that has at least one second through-hole; a second communication passage communicating between said compressed air-filled chamber and said second side wall is provided and the annular groove-shaped second air supply chamber is formed in said second side wall, said second communication passage and said at least one second through-hole being communicated with each other through said annular groove-shaped second air supply chamber. a compressed air-filled chamber in a center of the valve body; a compressed air supply port through which compressed air is supplied into said compressed air-filled chamber; a first side wall joined to a first air chamber block that defines a first air chamber and that has at least one first through-hole; a first communication passage communicating between said compressed air-filled chamber and said first side wall; an annular groove-shaped first air supply chamber formed in said first side wall, said first communication passage and said at least one first through-hole being communicated with each other through said annular groove-shaped first air supply chamber; and an annular groove-shaped second air supply chamber; characterized in that a second side wall is joined to a second air chamber block that defines a second air chamber and that has at least one second through-hole; a second communication passage communicating between said compressed air-filled chamber and said second side wall is provided and the annular groove-shaped second air supply chamber is formed in said second side wall, said second communication passage and said at least one second through-hole being communicated with each other through said annular groove-shaped second air supply chamber.
Process for the manufacturing of a drug delivery system based on a polymer comprising dispersed bioactive agent via the following process steps: (a) dissolving a polymer in an organic solvent (b) mixing the dissolved polymer with the bioactive agent (c) laminating the mixture between at least two sheets of polymeric material, whereby at least one sheet is permeable to the organic solvent, (d) delamination of the two polymeric sheets to provide a film. (a) dissolving a polymer in an organic solvent (b) mixing the dissolved polymer with the bioactive agent (c) laminating the mixture between at least two sheets of polymeric material, whereby at least one sheet is permeable to the organic solvent, (d) delamination of the two polymeric sheets to provide a film.
A measurement module for high frequency ground monitoring, comprising: at least one processor; at least one memory including computer program code, wherein the computer program code, when executed by operation of the at least one processor, performs an operation comprising: receiving a defined system topology of a system and information on characteristics of components (110,110,110) in the system; calculating an expected system impedance for the system; conducting one or more measurements of actual system impedance of the system using a high frequency voltage stimulus; and comparing the one or more measurements of actual system impedance with the expected system impedance to determine adequacy of protective grounding of the system. at least one processor; at least one memory including computer program code, wherein the computer program code, when executed by operation of the at least one processor, performs an operation comprising: receiving a defined system topology of a system and information on characteristics of components (110,110,110) in the system; calculating an expected system impedance for the system; conducting one or more measurements of actual system impedance of the system using a high frequency voltage stimulus; and comparing the one or more measurements of actual system impedance with the expected system impedance to determine adequacy of protective grounding of the system.
Insulation displacement contact for contacting a conductor line of an insulated ribbon cable, the insulation displacement contact having a tubular body, the tubular body extending along a longitudinal axis towards an open end, the open end comprising at least two separate cutting edges, wherein, on opposing side surfaces (8, 10) of the tubular body, slots (12, 14) are provided that extend to the open end, where they are located between the at least two cutting edges, wherein the slot on one of the opposing side surfaces is formed as a contacting slot and the slot on the other of the opposing side surfaces is formed as a positioning slot, wherein a clear width of the contacting slot is smaller than a clear width of the positioning slot, wherein the contacting slot has a first end opposite the open end and the positioning slot has a second end opposite the open end, and wherein the first end and second end are offset from one another along the longitudinal axis, characterized in that the first end is further spaced apart from the open end than the second end.
A self-recovering energy dissipation support with a shape memory alloy damper, comprising a shape memory alloy damper and cross-shaped steel columns, wherein the shape memory alloy damper is composed of a set of two rectangular steel-tube inner sleeves and a set of two outer sleeves; both ends of the inner sleeves are provided with a damper inner end plate with holes on four comers; the set of two rectangular steel-tube inner sleeves are connected by inserting superelastic shape memory alloy rods I into the damper inner end plates with holes in a stretching and anchoring manner; the set of two rectangular steel-tube inner sleeves and the set of the two outer sleeves are respectively connected by inserting superelastic shape memory alloy rods II into inner sleeve connecting plates with holes and outer sleeve connecting plates with the holes in a stretching and anchoring manner; the outer sleeves of the shape memory alloy damper are connected with cross-shaped steel column end plates; and the cross-shaped steel columns are connected with an external building structure through a semicircular connecting plate with a bolt hole at an end; the outer wall of each inner sleeve is provided with a grooved track symmetric about a symmetric axis of a section of said grooved track; the grooved track is grooved close to a first end surface of the inner sleeve, and is rectangular close to a second end surface of the inner sleeve; the second end surface of the inner sleeve is symmetrically provided with the inner sleeve connecting plates with holes; and the inner wall of each outer sleeve is provided with a convex track corresponding to the grooved track; the convex track is convex close to a first end surface of the outer sleeve and is rectangular close to a second end surface of the outer sleeve; and the first end surface of the outer sleeve is symmetrically provided with the outer sleeve connecting plates with holes.
A refrigerator, comprising: a barrier partitioning an interior of the refrigerator into a freezing compartment and a refrigerating compartment; a recess formed in the barrier and having a predetermined depth; a cover selectively positioned across an open top of the recess; a seating step formed along a peripheral portion of the recess, wherein a corresponding peripheral portion of the cover is seated on the seating step; and a guide groove extending outward from the seating step along the barrier to guide a sliding movement of the cover characterized in that a distance between two opposite outer peripheral edges of the seating step is equal to a width of the guide groove, wherein the height of the seating step is equal to the height of the guide groove, and wherein the guide groove extends from the peripheral portion of the recess toward a rear side of the interior of the refrigerator. a barrier partitioning an interior of the refrigerator into a freezing compartment and a refrigerating compartment; a recess formed in the barrier and having a predetermined depth; a cover selectively positioned across an open top of the recess; a seating step formed along a peripheral portion of the recess, wherein a corresponding peripheral portion of the cover is seated on the seating step; and a guide groove extending outward from the seating step along the barrier to guide a sliding movement of the cover characterized in that a distance between two opposite outer peripheral edges of the seating step is equal to a width of the guide groove, wherein the height of the seating step is equal to the height of the guide groove, and wherein the guide groove extends from the peripheral portion of the recess toward a rear side of the interior of the refrigerator.
A method of broadcasting a plurality of data packets at periodic intervals, comprising: setting, by a controller, a transmission interval of at least one data packet such that a transmission rate of the at least one data packet is compatible with a receiver rate of a receiving device within a transmission range of the at least one data packet, wherein the transmission interval is equal to a Bluetooth Low Energy, BLE, transmission interval for a single beacon protocol divided by a number of interleaved beacon protocols, wherein the at least one data packet is a BLE Advertising Protocol Data Unit; populating, by the controller, a portion of the at least one data packet with a first protocol, the first protocol including first protocol data; enabling, by the controller, transmission of the populated at least one data packet on a BLE sub-system controlled by the controller; and after delaying for an interleave interval, which is a function of the transmission interval, wherein the interleave interval is equal to a repeat factor, representing an approximation of how many times a BLE transmission should use a given beacon protocol and data, multiplied by the transmission interval, populating, by the controller, the at least one data packet with a second protocol including second protocol data, wherein the number of interleaved beacon protocols comprises the first and second protocols. setting, by a controller, a transmission interval of at least one data packet such that a transmission rate of the at least one data packet is compatible with a receiver rate of a receiving device within a transmission range of the at least one data packet, wherein the transmission interval is equal to a Bluetooth Low Energy, BLE, transmission interval for a single beacon protocol divided by a number of interleaved beacon protocols, wherein the at least one data packet is a BLE Advertising Protocol Data Unit; populating, by the controller, a portion of the at least one data packet with a first protocol, the first protocol including first protocol data; enabling, by the controller, transmission of the populated at least one data packet on a BLE sub-system controlled by the controller; and after delaying for an interleave interval, which is a function of the transmission interval, wherein the interleave interval is equal to a repeat factor, representing an approximation of how many times a BLE transmission should use a given beacon protocol and data, multiplied by the transmission interval, populating, by the controller, the at least one data packet with a second protocol including second protocol data, wherein the number of interleaved beacon protocols comprises the first and second protocols.
Method for lyophilizing RNA, wherein the method comprises the following steps: a) providing a liquid comprising at least one RNA and at least one lyoprotectant; b) introducing the liquid provided into a freeze drying chamber of a freeze dryer; c) cooling the liquid to a freezing temperature, wherein the cooling is performed at a defined cooling rate, which is in a range from 0.1 °C/min to 2°C/min; d) freezing the liquid at the freezing temperature in order to obtain a frozen liquid; e) reducing the pressure in the freeze drying chamber to a pressure below atmospheric pressure subsequently to the freezing of the liquid provided in step a); f) drying the frozen liquid obtained in step d) in order to obtain a lyophilized composition comprising the at least one RNA and at least one lyoprotectant; and g) equilibrating the pressure in the freeze drying chamber to atmospheric pressure and removing the lyophilized composition comprising the at least one RNA and the at least one lyoprotectant obtained in step f) from the freeze drying chamber, wherein step f) comprises heating the frozen liquid obtained in step d) to a pre-determined drying temperature, which does not exceed the melting temperature of the frozen liquid obtained in step d), wherein the heating is performed at a defined heating rate in a range from 0.1 °C/h to 20°C/h. a) providing a liquid comprising at least one RNA and at least one lyoprotectant; b) introducing the liquid provided into a freeze drying chamber of a freeze dryer; c) cooling the liquid to a freezing temperature, wherein the cooling is performed at a defined cooling rate, which is in a range from 0.1 °C/min to 2°C/min; d) freezing the liquid at the freezing temperature in order to obtain a frozen liquid; e) reducing the pressure in the freeze drying chamber to a pressure below atmospheric pressure subsequently to the freezing of the liquid provided in step a); f) drying the frozen liquid obtained in step d) in order to obtain a lyophilized composition comprising the at least one RNA and at least one lyoprotectant; and g) equilibrating the pressure in the freeze drying chamber to atmospheric pressure and removing the lyophilized composition comprising the at least one RNA and the at least one lyoprotectant obtained in step f) from the freeze drying chamber,
Electrode for production of aluminium metal by electrolysis of an aluminium containing compound dissolved in a molten electrolyte, where the electrowinning process is performed in smelting cells of conventional Hall-Heroult design, where the electrode comprises a calcinated carbon containing body having fixed thereto at least one composite metallic conductor comprising conducting elements of a Fe containing material and conducting elements of a Cu containing material, characterised in that the composite conductor comprises an electronic conductive diffusion barrier layer material at the interface between the two conducting materials wherein the barrier layer is constituted by a ceramic material or a metallic material of Mo, W or Ru.
A sealer and inflator composition, comprising: a concentrate comprising a polymer emulsion and a carrier; and a propellant/inflator comprising tetrafluoropropene wherein the polymer emulsion comprises an elastomeric polymer. a concentrate comprising a polymer emulsion and a carrier; and a propellant/inflator comprising tetrafluoropropene wherein the polymer emulsion comprises an elastomeric polymer.
An electronic apparatus, comprising: one or more substrates; a controller coupled to the one or more substrates, the controller configured to allocate a first secure portion of a pooled memory to a first instantiation of an application on a first node, wherein the first secure portion of the pooled memory is configured to be encrypted and holds data used by the first instantiation of the application, and the encryption is based on a key identity; and circuitry coupled to the one or more substrates and the controller, the circuitry configured to: provide a failover interface for a second instantiation of the application on a second node to access the first secure portion of the pooled memory, in the event of a failure of the first node; authenticate, through a trusted source, the second instantiation of the application, based on authentication information for the second instantiation of the application; and receive, from the pooled memory, the key identity to enable the second instantiation of the application in the second node to access the data in the first secure portion of the pooled memory, in the event the first node has failed and the second instantiation of the application is authenticated. one or more substrates; a controller coupled to the one or more substrates, the controller configured to allocate a first secure portion of a pooled memory to a first instantiation of an application on a first node, wherein the first secure portion of the pooled memory is configured to be encrypted and holds data used by the first instantiation of the application, and the encryption is based on a key identity; and circuitry coupled to the one or more substrates and the controller, the circuitry configured to: provide a failover interface for a second instantiation of the application on a second node to access the first secure portion of the pooled memory, in the event of a failure of the first node; authenticate, through a trusted source, the second instantiation of the application, based on authentication information for the second instantiation of the application; and receive, from the pooled memory, the key identity to enable the second instantiation of the application in the second node to access the data in the first secure portion of the pooled memory, in the event the first node has failed and the second instantiation of the application is authenticated. provide a failover interface for a second instantiation of the application on a second node to access the first secure portion of the pooled memory, in the event of a failure of the first node; authenticate, through a trusted source, the second instantiation of the application, based on authentication information for the second instantiation of the application; and receive, from the pooled memory, the key identity to enable the second instantiation of the application in the second node to access the data in the first secure portion of the pooled memory, in the event the first node has failed and the second instantiation of the application is authenticated.