A resource configuration method of a demodulation reference signal, wherein the method comprises: determining the number of transmission layers of User Equipment, UE, for transmitting uplink data; selecting, based on the determined number of transmission layers, a combinational configuration of Cyclic Shift, CS, and Orthogonal Cover Code, OCC, sequence that is required for generating respective Demodulation Reference Signal, DMRS, sequences of the transmission layers of the UE for transmitting uplink data, from one of preset multiple combinational configuration items of CS and OCC sequence, wherein the combinational configuration items are set with respect to the maximum number of transmission layers supportable by the system and are required for generating respective DMRS sequences of transmission layers, and wherein a first configuration condition is satisfied among the preset combinational configuration items, and the first configuration condition comprises that different OCC sequences are configured among at least a part of the combinational configuration items which are configured with at least two same CS resources; generating control signaling and delivering the control signaling to the UE, wherein the control signaling contains configuration indication information, and the configuration indication information indicates the selected combinational configuration of the CS and OCC sequence that is required for generating respective DMRS sequences of the transmission layers of the UE for transmitting uplink data; characterised in that each of the preset combinational configuration items also satisfies a second configuration condition; wherein the second configuration condition comprises that, in a combinational configuration item, the spacing between CS resources corresponding to the transmission layers mapped to the same codeword is greater than the spacing between CS resources corresponding to the transmission layers mapped to different codewords. determining the number of transmission layers of User Equipment, UE, for transmitting uplink data; selecting, based on the determined number of transmission layers, a combinational configuration of Cyclic Shift, CS, and Orthogonal Cover Code, OCC, sequence that is required for generating respective Demodulation Reference Signal, DMRS, sequences of the transmission layers of the UE for transmitting uplink data, from one of preset multiple combinational configuration items of CS and OCC sequence, wherein the combinational configuration items are set with respect to the maximum number of transmission layers supportable by the system and are required for generating respective DMRS sequences of transmission layers, and wherein a first configuration condition is satisfied among the preset combinational configuration items, and the first configuration condition comprises that different OCC sequences are configured among at least a part of the combinational configuration items which are configured with at least two same CS resources; generating control signaling and delivering the control signaling to the UE, wherein the control signaling contains configuration indication information, and the configuration indication information indicates the selected combinational configuration of the CS and OCC sequence that is required for generating respective DMRS sequences of the transmission layers of the UE for transmitting uplink data; characterised in that each of the preset combinational configuration items also satisfies a second configuration condition; wherein the second configuration condition comprises that, in a combinational configuration item, the spacing between CS resources corresponding to the transmission layers mapped to the same codeword is greater than the spacing between CS resources corresponding to the transmission layers mapped to different codewords.