A compound of Formula wherein R 1 denotes absent or denotes A or Q-Het, Z denotes a group: wherein X denotes O, S or N, Y denotes C or N, T denotes C or N, or Z denotes a pyridine or a pyridazine group, R a is absent or denotes OR 3, CF 3, Hal, NO 2, R b is absent or denotes one of the groups selected from A and COHet, R 2 denotes H, Het, Q-Het, Cyc, A or OA, Het denotes a 4-9 membered monocyclic ring or a fused, spiro or bridged bicyclic ring, which is saturated, unsaturated, or aromatic, which contains 1 to 3 heteroatoms independently selected from N, O, S and a group CO, SO or SO 2, and wherein 1 or 2 H atoms may be replaced by A, OA, COA, CN, Hal, NO 2, OR 3, SOA and/or SO 2 A, Cyc denotes a 4-8 saturated carbocyclic ring optionally containing a group SO, SO 2, CO, and optionally substituted once or twice by a group selected from CO(NR 3) 2, and COHet, OR 3, Het 1, A, CH 2 Het 1, NH 2, NHCOA, OCH 2 Cyc 1, SO 2 A and/or -SA(=NH)(=O), Q denotes a linear or branched alkylene, having 1 to 6 carbon atoms wherein 1-5 H atoms may be replaced by a groupe independently selected from OR 3, Hal, N(R 3) 2, and wherein 1 or 2 CH 2 groups may be replaced by a group independently selected from CO, SO, SO 2 and NR 3, or Q denotes a 4-8-membered bivalent heterocyclic ring, which is saturated, unsaturated or aromatic and which contains 1 to 3 heteroatoms independently selected from N, O and S, A denotes a linear or branched alkyl having 1 to 10 carbon atoms wherein 1 to 7 H atoms may be replaced by a group independently selected from -OR 3, Hal, NHSO 2 A, SO 2 A, SOA, N(R 3) 2, and wherein 1, 2 or 3 non-adjacent -CH 2 - groups may be replaced by a group independently selected from -CO-, NR 3 and/or -O-, Hal denotes F, Cl, Br or I, R 3 denotes H or C 1 -C 6 -alkyl wherein 1 H atom may be replaced by a group selected from OH, O-C 1 -C 6 -alkyl, and Hal, Het 1 denotes a five- or six membered saturated monocyclic heterocycle which contains 1-3 N- and/or O-atoms, which optionally is monosubstituted by A, Cyc 1 denotes cycloalkyl with 3-7 atoms, and pharmaceutically acceptable solvates, tautomers, salts, hydrates and stereoisomers thereof, including mixtures thereof in all ratios. R 1 denotes absent or denotes A or Q-Het, Z denotes a group: X denotes O, S or N, Y denotes C or N, T denotes C or N, or Z denotes a pyridine or a pyridazine group, R a is absent or denotes OR 3, CF 3, Hal, NO 2, R b is absent or denotes one of the groups selected from A and COHet, R 2 denotes H, Het, Q-Het, Cyc, A or OA, Het denotes a 4-9 membered monocyclic ring or a fused, spiro or bridged bicyclic ring, which is saturated, unsaturated, or aromatic, which contains 1 to 3 heteroatoms independently selected from N, O, S and a group CO, SO or SO 2, and wherein 1 or 2 H atoms may be replaced by A, OA, COA, CN, Hal, NO 2, OR 3, SOA and/or SO 2 A, Cyc denotes a 4-8 saturated carbocyclic ring optionally containing a group SO, SO 2, CO, and optionally substituted once or twice by a group selected from CO(NR 3) 2, and COHet, OR 3, Het 1, A, CH 2 Het 1, NH 2, NHCOA, OCH 2 Cyc 1, SO 2 A and/or -SA(=NH)(=O), Q denotes a linear or branched alkylene, having 1 to 6 carbon atoms wherein 1-5 H atoms may be replaced by a groupe independently selected from OR 3, Hal, N(R 3) 2, and wherein 1 or 2 CH 2 groups may be replaced by a group independently selected from CO, SO, SO 2 and NR 3, or Q denotes a 4-8-membered bivalent heterocyclic ring, which is saturated, unsaturated or aromatic and which contains 1 to 3 heteroatoms independently selected from N, O and S, A denotes a linear or branched alkyl having 1 to 10 carbon atoms wherein 1 to 7 H atoms may be replaced by a group independently selected from -OR 3, Hal, NHSO 2 A, SO 2 A, SOA, N(R 3) 2, and wherein 1, 2 or 3 non-adjacent -CH 2 - groups may be replaced by a group independently selected from -CO-, NR 3 and/or -O-, Hal denotes F, Cl, Br or I, R 3 denotes H or C 1 -C 6 -alkyl wherein 1 H atom may be replaced by a group selected from OH, O-C 1 -C 6 -alkyl, and Hal, Het 1 denotes a five- or six membered saturated monocyclic heterocycle which contains 1-3 N- and/or O-atoms, which optionally is monosubstituted by A, Cyc 1 denotes cycloalkyl with 3-7 atoms,