mhurhangee/ep-ind-claims huggingface dataset:
Use of compounds of the following formula: wherein: - R 1, R 2 and R 3, identical or different and independently of one another, represent a hydrogen or halogen atom, a hydroxyl radical, an alkyl, perfluoroalkyl, alkoxy, alkylthio, nitrile group, a substituted alkoxy, or a fused heterocycle obtained from two of the adjacent R 1, R 2 and R 3 radicals, that can form, jointly with the carbon atoms of the phenyl cycle to which they are bonded, a fused heterocycle, - X represents a sulphur or oxygen atom, - Y represents a substituted or unsubstituted mono- or polycyclic heteroaryl group, a -NH-(C=O)-R 6, - (C=O)-NH-R 6 or -NH-(C=O)-NH-R 6 group wherein R 6 represents an unsubstituted aryl group; an aryl group comprising one or several substituents chosen from a halogen atom and an alkyl, alkoxy or mono- or dialkylamino radical; a mono- or polycyclic heteroaryl group; a linear or branched alkyl radical; a saturated or unsaturated mono- or polycyclic hydrocarbon group; - R 4 and R 5, identical or different and independently of one another, represent a hydrogen or halogen atom, an alkoxy, alkylthio, alkyl, perfluoroalkyl, nitrile or nitro group, for the manufacture of a drug for the treatment of tumours associated with a hyperactivation of the Hedgehog protein signalling pathway, said tumours being chosen from nerve tissue tumours (medulloblastomas, primitive neuroectodermal tumours, glioblastomas, meningeomas and oligodendrogliomas), skin tumours (basal cell carcinomas, trichoepitheliomas), bone and muscle tissue tumours (rhabdomyosarcomas, osteosarcomas) or tumours of other tissues (kidney, bladder) or pathologies of the neurodegenerative type chosen from multiple sclerosis or motor neuron disease. - R 1, R 2 and R 3, identical or different and independently of one another, represent a hydrogen or halogen atom, a hydroxyl radical, an alkyl, perfluoroalkyl, alkoxy, alkylthio, nitrile group, a substituted alkoxy, or a fused heterocycle obtained from two of the adjacent R 1, R 2 and R 3 radicals, that can form, jointly with the carbon atoms of the phenyl cycle to which they are bonded, a fused heterocycle, - X represents a sulphur or oxygen atom, - Y represents a substituted or unsubstituted mono- or polycyclic heteroaryl group, a -NH-(C=O)-R 6, - (C=O)-NH-R 6 or -NH-(C=O)-NH-R 6 group wherein R 6 represents an unsubstituted aryl group; an aryl group comprising one or several substituents chosen from a halogen atom and an alkyl, alkoxy or mono- or dialkylamino radical; a mono- or polycyclic heteroaryl group; a linear or branched alkyl radical; a saturated or unsaturated mono- or polycyclic hydrocarbon group; - R 4 and R 5, identical or different and independently of one another, represent a hydrogen or halogen atom, an alkoxy, alkylthio, alkyl, perfluoroalkyl, nitrile or nitro group,
A magnetic resonance imaging device, comprising a main magnet system, a gradient coil system, a signal processing system, a support or bed, and an RF System comprising an RF transmitter coil subsystem and an RF receiver coil subsystem, the RF receiver coil subsystem comprising at least one first coil-like element, and at least one second coil-like element assigned to an object to be analyzed by the magnetic resonance imaging device, wherein the or each first coil-like element is assigned to a main magnet system of the magnetic resonance imaging device, wherein the or each first coil-like element is positioned below, preferably directly below, the support or bed on which the object to be analyzed is placed, wherein the or each second coil-like element is positioned above, preferably directly above, the object to be analyzed by the magnetic resonance imaging device, wherein the or each second coil-like element is designed as a wearable unit, wherein said wearable unit is attachable to the object to be analyzed, outside the magnetic resonance imaging device and before MRI analysis.
A method of determining analyte concentration in physiological fluid, the method comprising: providing a reagent disposed between a first working electrode and a second working electrode; depositing a physiological fluid on the reagent; and applying an electrical potential to the first and second working electrodes to transform an analyte in the physiological fluid into a different form and generate a current transient from each of the first and second working electrodes (12, 14); wherein the method is characterized by determining a peak in the current transient for each of the first and second working electrodes (12, 14); measuring a value of the current transient at a first predetermined temporal offset from the peak of the current transient from the first working electrode, and measuring a value of the current transient at a second predetermined temporal offset from the peak of the current transient from the second working electrode, wherein the second time offset is different from the first time offset; and calculating the analyte concentration from the measured current values of the working electrodes in the measuring step. providing a reagent disposed between a first working electrode and a second working electrode; depositing a physiological fluid on the reagent; and applying an electrical potential to the first and second working electrodes to transform an analyte in the physiological fluid into a different form and generate a current transient from each of the first and second working electrodes (12, 14); wherein the method is characterized by determining a peak in the current transient for each of the first and second working electrodes (12, 14); measuring a value of the current transient at a first predetermined temporal offset from the peak of the current transient from the first working electrode, and measuring a value of the current transient at a second predetermined temporal offset from the peak of the current transient from the second working electrode, wherein the second time offset is different from the first time offset; and calculating the analyte concentration from the measured current values of the working electrodes in the measuring step.
A method of operating an electronic device, the method comprising: emitting a first sound from the electronic device, the first sound being an ultrasonic sound; receiving a second sound at the electronic device, the second sound based at least in part on the first sound; comparing, at a processor of the electronic device, at least one characteristic of the first sound to at least one corresponding characteristic of the second sound; receiving, at the processor, output data from at least one sensor; and modifying an output parameter of the electronic device upon which a notification output is based in response to the comparison of the first sound and the second sound and the output data from the at least one sensor. emitting a first sound from the electronic device, the first sound being an ultrasonic sound; receiving a second sound at the electronic device, the second sound based at least in part on the first sound; comparing, at a processor of the electronic device, at least one characteristic of the first sound to at least one corresponding characteristic of the second sound; receiving, at the processor, output data from at least one sensor; and modifying an output parameter of the electronic device upon which a notification output is based in response to the comparison of the first sound and the second sound and the output data from the at least one sensor.
Wind turbine for converting wind into mechanical energy, comprising a support and a vane (6, 16) rotatively connected to said support, the vane (6, 16) comprising a wind receptacle that can adopt a first configuration when the vane (6,16) is in a position to travel in the direction of the wind, in which first configuration the receptacle has a first capacity to convert wind force into motion of the vane (6, 16), and a second configuration when the vane (6,16) is in a position to travel against the direction of the wind, in which second configuration the receptacle has a second capacity to convert wind force into motion of the vane (6,16), the second capacity being lower than the first capacity, wherein the turbine is provided with a means (200, 200') that is operable to force the receptacle to adopt at least one of the said configurations independent from the direction of the wind, characterised in that the vane (6, 16) comprises multiple receptacles positioned along the length of the vane wherein a receptacle (7; 6,10) positioned near the support has a larger cross-section than a receptacle (7, 6,11) positioned further away from the support.
A surgical anvil assembly for use with a circular stapling instrument, comprising: an anvil center rod; an anvil head having a post pivotally coupled to the anvil center rod, the anvil head being movable relative to the anvil center rod between a first, operative condition and a second, tilted condition; a cam latch coupled to the post of the anvil head and pivotal therewith relative to the anvil center rod, the cam latch having an outer surface including a camming region and a notched region disposed adjacent the camming region; and a plunger at least partially received in the anvil center rod and spring biased in a distal direction to pivot the anvil head toward the second, tilted condition, wherein the plunger is configured to be received in the notched region of the cam latch, the plunger having a distal end comprising a plunger finger; the notched region of the cam latch includes a stop surface that extends substantially radially inward from an end of the camming region, wherein the plunger finger is configured to contact the camming region of the cam latch to bias the cam latch and, in turn, the anvil head, toward the second, tilted condition, characterised in that the stop surface engages the plunger finger upon the anvil head entering the second, tilted condition to resist movement of the anvil head out of the second, tilted condition. an anvil center rod; an anvil head having a post pivotally coupled to the anvil center rod, the anvil head being movable relative to the anvil center rod between a first, operative condition and a second, tilted condition; a cam latch coupled to the post of the anvil head and pivotal therewith relative to the anvil center rod, the cam latch having an outer surface including a camming region and a notched region disposed adjacent the camming region; and a plunger at least partially received in the anvil center rod and spring biased in a distal direction to pivot the anvil head toward the second, tilted condition, wherein the plunger is configured to be received in the notched region of the cam latch, the plunger having a distal end comprising a plunger finger; the notched region of the cam latch includes a stop surface that extends substantially radially inward from an end of the camming region, wherein the plunger finger is configured to contact the camming region of the cam latch to bias the cam latch and, in turn, the anvil head, toward the second, tilted condition, characterised in that the stop surface engages the plunger finger upon the anvil head entering the second, tilted condition to resist movement of the anvil head out of the second, tilted condition.
Operational assembly of a hydrocleaner intended to be mounted on a carrier vehicle provided with a frame, the operational assembly comprising a plurality of items of operational equipment (8, 25, 26, 27, 34), said operational assembly comprising two operational modules (9A, 9B) both comprising said operational equipment (8, 25, 26, 27, 34), namely a first operational module provided with at least one tank and a second operational module provided with at least one pumping system, characterized in that it comprises two subframes (10A, 10B), each of said operational modules (9A, 9B) being capable of being fixed on one of said subframes (10A, 10B), and in that each of said subframes (10A, 10B) is adaptable by width to different carrier vehicle frames and is adapted to the frame of the carrier vehicle on which it is intended to be mounted.
Method for applying a spray to an area of agricultural land by means of a spray nozzle unit of an agricultural spraying device, with the steps of: - detecting a first field portion (A1-E4) of the area of agricultural land by means of an optical detecting unit (18, 18A-C), in order to obtain a first item of image information from the first field portion (A1-E4); - identifying plants in a first evaluation region of the obtained first item of image information of the first field portion (A1-E4) by means of a control unit; - ascertaining a first plant parameter of the first evaluation region by means of the control unit by using the identified plants in the first evaluation region; and - applying the spray at a defined minimum amount per surface area to substantially the entire first field portion (A1-E4) of the area of agricultural land in dependence on the ascertained first plant parameter of the first evaluation region by means of the spray nozzle unit of the agricultural spraying device, characterized in that, in the step of applying, the spray is also applied at the defined minimum amount per surface area to substantially the entire second field portion (A1-E4) of the area of agricultural land adjoining the first field portion (A1-E4) in the direction of movement of the agricultural spraying device in dependence on the ascertained first plant parameter of the first evaluation region by means of the spray nozzle unit of the agricultural spraying device. - detecting a first field portion (A1-E4) of the area of agricultural land by means of an optical detecting unit (18, 18A-C), in order to obtain a first item of image information from the first field portion (A1-E4); - identifying plants in a first evaluation region of the obtained first item of image information of the first field portion (A1-E4) by means of a control unit; - ascertaining a first plant parameter of the first evaluation region by means of the control unit by using the identified plants in the first evaluation region; and - applying the spray at a defined minimum amount per surface area to substantially the entire first field portion (A1-E4) of the area of agricultural land in dependence on the ascertained first plant parameter of the first evaluation region by means of the spray nozzle unit of the agricultural spraying device,
Method for identifying a reagent during a process in an analysis system, wherein the analysis system comprises a liquid chromatograph and a mass spectrometer, the method comprising: - providing a reagent, wherein the reagent is used for treatment of a sample in order to prepare the sample for analysis in the analysis system, - adding before the sample is input into the liquid chromatograph at least one chemical substance to the reagent and the sample, the at least one chemical substance having a concentration being above a detection level of the mass spectrometer, - processing the sample and the reagent together with the chemical substance by means of the analysis system, whereby the sample, reagent and chemical substance pass through the liquid chromatograph and are input into the mass spectrometer, and - identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance, wherein the reagent is continuously identified within a time range from the input of the reagent into the analysis system to the discharge or removal of the reagent from the analysis system by continuously monitoring with the mass spectrometer the constant background signal caused by the chemical substance at any time during the analysis in order to detect whether the reagent has passed a target or correct liquid chromatography channel of the liquid chromatograph. - providing a reagent, wherein the reagent is used for treatment of a sample in order to prepare the sample for analysis in the analysis system, - adding before the sample is input into the liquid chromatograph at least one chemical substance to the reagent and the sample, the at least one chemical substance having a concentration being above a detection level of the mass spectrometer, - processing the sample and the reagent together with the chemical substance by means of the analysis system, whereby the sample, reagent and chemical substance pass through the liquid chromatograph and are input into the mass spectrometer, and - identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance, wherein the reagent is continuously identified within a time range from the input of the reagent into the analysis system to the discharge or removal of the reagent from the analysis system by continuously monitoring with the mass spectrometer the constant background signal caused by the chemical substance at any time during the analysis in order to detect whether the reagent has passed a target or correct liquid chromatography channel of the liquid chromatograph.
A seat system (1; 42) for a vehicle, comprising: a seat frame (2; 44); a seatback structure (7; 46) coupled to the seat frame (2; 44); and at least one adjustment device (10; 56) coupled to the seat system (1; 42) and comprising an actuator or at least one biasing device, at least one cable or at least one strap extending at least partially across a single, integrally formed, one-piece structure of the seatback structure (7; 46), wherein the adjustment device (10; 56) is configured to alter a contour of a seating surface of the single, integrally formed, one-piece structure of the seatback structure (7; 46), wherein the seating surface is configured to engage at least a lumbar portion of an occupant of the seat system (1; 42). a seat frame (2; 44); a seatback structure (7; 46) coupled to the seat frame (2; 44); and at least one adjustment device (10; 56) coupled to the seat system (1; 42) and comprising an actuator or at least one biasing device, at least one cable or at least one strap extending at least partially across a single, integrally formed, one-piece structure of the seatback structure (7; 46), wherein the adjustment device (10; 56) is configured to alter a contour of a seating surface of the single, integrally formed, one-piece structure of the seatback structure (7; 46), wherein the seating surface is configured to engage at least a lumbar portion of an occupant of the seat system (1; 42).
A method for attaching an anchor to a cable, comprising: a. providing an anchor having a neck end, an open end, and a strand cavity passing through said anchor from said neck end to said open end; b. providing a cable including a plurality of strands and a free end; c. placing said plurality of strands of said cable within said strand cavity of said anchor, so that said free end of said cable lies proximate said open end of said anchor; d. providing an anchor holding fixture; e. attaching said anchor to said anchor holding fixture; f. providing a cable holding fixture; g. attaching said cable to said cable holding fixture; h. aligning said cable holding fixture and said anchor holding fixture; i. providing an anchor sealing surface on said open end of said anchor; j. providing a sealing body; k. mating said sealing body with said anchor sealing surface; l. providing an injection orifice; m. providing a potting compound which transitions from a liquid state to a solid state over time; n. injecting said potting compound, in said liquid state, through said injection orifice and into said strand cavity, so that said liquid potting compound infuses throughout substantially all of said strand cavity; and o. allowing said liquid potting compound to harden into a solid, thereby locking said cable within said anchor. a. providing an anchor having a neck end, an open end, and a strand cavity passing through said anchor from said neck end to said open end; b. providing a cable including a plurality of strands and a free end; c. placing said plurality of strands of said cable within said strand cavity of said anchor, so that said free end of said cable lies proximate said open end of said anchor; d. providing an anchor holding fixture; e. attaching said anchor to said anchor holding fixture; f. providing a cable holding fixture; g. attaching said cable to said cable holding fixture; h. aligning said cable holding fixture and said anchor holding fixture; i. providing an anchor sealing surface on said open end of said anchor; j. providing a sealing body; k. mating said sealing body with said anchor sealing surface; l. providing an injection orifice; m. providing a potting compound which transitions from a liquid state to a solid state over time; n. injecting said potting compound, in said liquid state, through said injection orifice and into said strand cavity, so that said liquid potting compound infuses throughout substantially all of said strand cavity; and o. allowing said liquid potting compound to harden into a solid, thereby locking said cable within said anchor.
A compound which is N -(3-(6-Amino-5-(2-( N -methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide; or a pharmaceutically acceptable salt thereof.
A method comprising: a processor, in a contact center, receiving a request to contact a user of a social media network; the processor reading a dialog script that directs the contacting of the user of social media network; the processor accessing a trend for a user of the social media network, wherein the trend describes a likely usage of the social media network; the processor determining, from the trend, to which social media network to post a message to the user of the of social media network and at what time to post the message on the social media network; and the processor posting the message to the determined social media network at the determined time. a processor, in a contact center, receiving a request to contact a user of a social media network; the processor reading a dialog script that directs the contacting of the user of social media network; the processor accessing a trend for a user of the social media network, wherein the trend describes a likely usage of the social media network; the processor determining, from the trend, to which social media network to post a message to the user of the of social media network and at what time to post the message on the social media network; and the processor posting the message to the determined social media network at the determined time.
A mixture obtained by adding a resin composition to a collected multi-layer structure that can be reground and containing hydrolyzed ethylene-vinyl acetate copolymer, the resin composition comprising polyolefin, metal salt of higher fatty acid having 12 to 30 carbon atoms and zeolite, wherein the content of zeolite in the resin composition is at least 5 % by weight and less than 50 % by weight.
An ink jet recording apparatus in which ejection orifices (1002; 37, 39; 31; 35; 104) for a pigment ink and ejection orifices (1001; 39, 37; 32; 33; 34; 36; 101; 105) for at least one type of reactive ink that destabilizes a dispersed state of a pigment in the pigment ink are capped with an identical cap (1003; 1107), and the cap (1003; 1107) comprises a unit for removing an ink in the cap (1003; 1107), characterized in that, when a mixed thickening ratio is represented by Y (%) and an ejection orifice-to-ejection orifice distance between the ejection orifice (1002; 37, 39; 31; 35; 104) for the pigment ink and the ejection orifice (1001; 39, 37; 32; 33; 34; 36; 101; 105) for the reactive ink is represented by X (mm) provided that X > 0, Y and X in the pigment ink and the reactive ink the ejection orifices (1002; 37, 39; 31; 35; 104; 1001; 39, 37; 32; 33; 34; 36; 101; 105) for which are capped with the identical cap (1003; 1107) satisfy a relationship represented by the following expression: Y ≤ 0.60X + 50.0 wherein the mixed thickening ratio refers to a ratio at which the viscosity of a mixture containing the pigment ink and the reactive ink in equal volumes increases as compared with the average viscosity of the pigment ink and the reactive ink, and is represented in a "%" unit.