A kit for the delivery of a therapeutic agent to an organ blood flow and the removal of the excess of said therapeutic agent from said organ blood flow, said kit comprises: a. optionally a therapeutic agent which is a fluid treatment and/or particles comprising a radioactive element, the size of said particles is comprised between 20 and 60 micrometers, b. a first retrievable medical device, for delivering said therapeutic agent into the organ inflow blood, comprising a catheter and an injection device, said catheter having a proximal end, a distal end and a lumen; the distal end is in fluid communication with the proximal end via the lumen; said injection device is suitable to be connected to the proximal end of the catheter, c. a second retrievable medical device for isolating the organ outflow, having a distal end and a proximal end; said second medical device comprises a catheter suitable for deploying a self-expanding hollow tubular member; the proximal end of the tubular member is attached to the distal end of the catheter; said tubular member is configured to expand radially to form a central part flanked by two annular ridges, a distal annular ridge and a proximal annular ridge wherein the central part radially expands to a lesser degree compared to the annular ridges (12, 13); said tubular member comprises a liquid-impermeable area disposed with one or more fluid ports for the collection of the organ outflow and two liquid-permeable regions, one distal to the distal annular ridge and one proximal to the proximal annular ridge so forming a passageway between the distal end and the proximal end of the tubular member for the flow the organ blood devoid of therapeutic agent, whereby the liquid-impermeable area is disposed in an area defined by the region flanked by the annular ridges (12, 13), the distal annular ridge and at least part of the proximal annular ridge isolating the organ outflow containing therapeutic agent excess from the organ blood flow devoid of therapeutic agent, and d. a separation device comprising at least one filter able to separate the therapeutic agent excess from the organ outflow, having an inlet for the organ outflow having a therapeutic agent excess and an outlet for filtered organ outflow blood, characterised in that the separation device is located in the second retrievable medical device, said separation device comprising at least one filter which is positioned at the inner proximal end of the tubular member of the second retrievable medical device. a. optionally a therapeutic agent which is a fluid treatment and/or particles comprising a radioactive element, the size of said particles is comprised between 20 and 60 micrometers, b. a first retrievable medical device, for delivering said therapeutic agent into the organ inflow blood, comprising a catheter and an injection device, said catheter having a proximal end, a distal end and a lumen; the distal end is in fluid communication with the proximal end via the lumen; said injection device is suitable to be connected to the proximal end of the catheter, c. a second retrievable medical device for isolating the organ outflow, having a distal end and a proximal end; said second medical device comprises a catheter suitable for deploying a self-expanding hollow tubular member; the proximal end of the tubular member is attached to the distal end of the catheter; said tubular member is configured to expand radially to form a central part flanked by two annular ridges, a distal annular ridge and a proximal annular ridge wherein the central part radially expands to a lesser degree compared to the annular ridges (12, 13); said tubular member comprises a liquid-impermeable area disposed with one or more fluid ports for the collection of the organ outflow and two liquid-permeable regions, one distal to the distal annular ridge and one proximal to the proximal annular ridge so forming a passageway between the distal end and the proximal end of the tubular member for the flow the organ blood devoid of therapeutic agent, whereby the liquid-impermeable area is disposed in an area defined by the region flanked by the annular ridges (12, 13), the distal annular ridge and at least part of the proximal annular ridge isolating the organ outflow containing therapeutic agent excess from the organ blood flow devoid of therapeutic agent, and d. a separation device comprising at least one filter able to separate the therapeutic agent excess from the organ outflow, having an inlet for the organ outflow having a therapeutic agent excess and an outlet for filtered organ outflow blood,