Method of filtering a large volume of a medium using a pre-sterilized, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors comprise the following sensors: a flow sensor arranged at the unfiltrate inlet; an inlet pressure sensor arranged at the unfiltrate inlet; an outlet liquid detector arranged at the filtrate outlet; an outlet pressure sensor arranged at the filtrate outlet, wherein the regulating means comprise the following regulating means: an inlet regulating valve arranged at the unfiltrate inlet; an outlet regulating valve arranged at the filtrate outlet; a controlled or regulated feed pump, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprising the following process steps: a) filling the single-use filtration device with a wetting medium using low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements, using a rinsing medium; e) filtering the medium using the filter elements; f) re-rinsing with a rinsing medium using high flow; and g) closing the main line; wherein at least steps d) and e) are controlled by the monitoring and control system, and wherein the process steps f) and g) are optional. wherein the sensors comprise the following sensors: a flow sensor arranged at the unfiltrate inlet; an inlet pressure sensor arranged at the unfiltrate inlet; an outlet liquid detector arranged at the filtrate outlet; an outlet pressure sensor arranged at the filtrate outlet, wherein the regulating means comprise the following regulating means: an inlet regulating valve arranged at the unfiltrate inlet; an outlet regulating valve arranged at the filtrate outlet; a controlled or regulated feed pump, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprising the following process steps: a) filling the single-use filtration device with a wetting medium using low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements, using a rinsing medium; e) filtering the medium using the filter elements; f) re-rinsing with a rinsing medium using high flow; and g) closing the main line; a) filling the single-use filtration device with a wetting medium using low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements, using a rinsing medium; e) filtering the medium using the filter elements; f) re-rinsing with a rinsing medium using high flow; and g) closing the main line; wherein at least steps d) and e) are controlled by the monitoring and control system, and wherein the process steps f) and g) are optional.