A method of acquiring medical image data (400, 500) with at least one region of interest (230, 402, 502) with a predefined freely shaped geometry, the method comprising the following steps: - acquiring a first set of medical image data, wherein the first set of medical image data is coarse survey image data, - performing an automated anatomy detection by using a segmentation technique to identify at least one anatomical landmark (406, 408, 410, 412, 414) in the first set of medical image data, - determining the at least one region of interest with a trained pattern recognition module using the at least one anatomical landmark, wherein the trained pattern recognition module was trained by an operator in a training step for enabling the trained pattern recognition module to determine a desired way of positioning the at least one region of interest using the anatomical landmark, - displaying the at least one region of interest graphically, - receiving a modification to the at least one region of interest from the operator, - using the modification to perform a further training step for the trained pattern recognition module for, during subsequent performing of the method, more accurately determining the at least one region of interest with the trained pattern recognition module - acquiring a second set of medical image data, wherein the second set of medical image data is diagnostic image data, wherein the second set of medical image data has a contrast, - adjusting the location and/or shape of the at least one region of interest with the trained pattern recognition module using the at least one anatomical landmark and the second set of medical image data, - calculating a second set of medical image data contrast metric of the second set of medical image data, - determining if the second set of medical image data contrast metric satisfies a second predetermined criterion, - alerting an operator if the second predetermined criterion is not satisfied and/or reacquiring the second set of medical image data if the second predetermined criterion is not satisfied and/or halting the step of adjusting the at least one region of interest if the second predetermined criterion is not satisfied and/or displaying a second user interface operable for receiving instructions from an operator which allows the operator to manually control the adjusting of the at least one region of interest if the second predetermined criterion is not satisfied. - acquiring a first set of medical image data, wherein the first set of medical image data is coarse survey image data, - performing an automated anatomy detection by using a segmentation technique to identify at least one anatomical landmark (406, 408, 410, 412, 414) in the first set of medical image data, - determining the at least one region of interest with a trained pattern recognition module using the at least one anatomical landmark, wherein the trained pattern recognition module was trained by an operator in a training step for enabling the trained pattern recognition module to determine a desired way of positioning the at least one region of interest using the anatomical landmark, - displaying the at least one region of interest graphically, - receiving a modification to the at least one region of interest from the operator, - using the modification to perform a further training step for the trained pattern recognition module for, during subsequent performing of the method, more accurately determining the at least one region of interest with the trained pattern recognition module - acquiring a second set of medical image data, wherein the second set of medical image data is diagnostic image data, wherein the second set of medical image data has a contrast, - adjusting the location and/or shape of the at least one region of interest with the trained pattern recognition module using the at least one anatomical landmark and the second set of medical image data, - calculating a second set of medical image data contrast metric of the second set of medical image data, - determining if the second set of medical image data contrast metric satisfies a second predetermined criterion, - alerting an operator if the second predetermined criterion is not satisfied and/or reacquiring the second set of medical image data if the second predetermined criterion is not satisfied and/or halting the step of adjusting the at least one region of interest if the second predetermined criterion is not satisfied and/or displaying a second user interface operable for receiving instructions from an operator which allows the operator to manually control the adjusting of the at least one region of interest if the second predetermined criterion is not satisfied.