A control handle for mitral valve repair, comprising: an outer clamp arm control mechanism which is configured to control a movement of an outer clamp arm of a tissue clamping device and includes a sleeve, a first control part, and a sliding part, wherein the sliding part is disposed in the sleeve, and the first control part rotates to drive the sliding part to move in the sleeve along a length direction of the sleeve, so as to control the opening and closing of the outer clamp arm; and an inner clamp arm control mechanism which is configured to control a movement of an inner clamp arm of the tissue clamping device and includes a housing and a second control part, wherein a second sliding groove is set on the housing, and the second control part passes through and moves along the second sliding groove to control the opening and closing of the inner clamp arm relative to the outer clamp arm; wherein the outer clamp arm control mechanism further includes a driving rod, a fixing block, and a protective cover; the sliding part controls the opening and closing of the outer clamp arm by the driving rod; a rear end of the driving rod is fixedly connected to the fixing block; the protective cover is detachably connected to the sliding part by a thread; and when connected to the sliding part, the protective cover restricts a relative movement of the fixing block and the sliding part. an outer clamp arm control mechanism which is configured to control a movement of an outer clamp arm of a tissue clamping device and includes a sleeve, a first control part, and a sliding part, wherein the sliding part is disposed in the sleeve, and the first control part rotates to drive the sliding part to move in the sleeve along a length direction of the sleeve, so as to control the opening and closing of the outer clamp arm; and the sliding part is disposed in the sleeve, and the first control part rotates to drive the sliding part to move in the sleeve along a length direction of the sleeve, so as to control the opening and closing of the outer clamp arm; and an inner clamp arm control mechanism which is configured to control a movement of an inner clamp arm of the tissue clamping device and includes a housing and a second control part, wherein a second sliding groove is set on the housing, and the second control part passes through and moves along the second sliding groove to control the opening and closing of the inner clamp arm relative to the outer clamp arm; wherein the outer clamp arm control mechanism further includes a driving rod, a fixing block, and a protective cover; the sliding part controls the opening and closing of the outer clamp arm by the driving rod; a rear end of the driving rod is fixedly connected to the fixing block; the protective cover is detachably connected to the sliding part by a thread; and when connected to the sliding part, the protective cover restricts a relative movement of the fixing block and the sliding part. a second sliding groove is set on the housing, and the second control part passes through and moves along the second sliding groove to control the opening and closing of the inner clamp arm relative to the outer clamp arm; wherein the outer clamp arm control mechanism further includes a driving rod, a fixing block, and a protective cover; the sliding part controls the opening and closing of the outer clamp arm by the driving rod; a rear end of the driving rod is fixedly connected to the fixing block; the protective cover is detachably connected to the sliding part by a thread; and when connected to the sliding part, the protective cover restricts a relative movement of the fixing block and the sliding part.