A system configured to provide respiratory therapy of a subject having an airway, the system comprising: a pressure generator configured to generate a pressurized flow for delivery to the airway of the subject during respiratory therapy, wherein the pressurized flow includes breathable gas; one or more sensors configured to generate one or more output signals conveying information related to one or more gas parameters of the pressurized flow; and one or more processors configured to execute processing modules, the processing modules comprising: a control module configured to control the pressure generator to provide the pressurized flow during a therapy session; a therapy module configured to adjust levels of one or more gas parameters of the pressurized flow; a usage module configured to gather usage information based on the provided pressurized flow; and a starting level module configured to determine a starting level of one or more gas parameters of the pressurized flow, wherein the determination is based on gathered usage information, wherein the gathered usage information corresponds to therapeutic usage of the system spanning at least a threshold amount of usage, wherein the threshold amount of usage is more than one therapy session, and wherein the gathered usage information pertains to a predetermined percentile of the pressure level of the generated pressurized flow, a predetermined range of percentiles of the pressure level of the generated pressurized flow, and/or another statistical metric based on the pressure level of the generated pressurized flow; wherein the therapy module is further configured to apply the starting level at a beginning of a therapy session, and wherein the starting level module is further configured to adjust the starting level of the one or more gas parameters of the pressurized flow such that consecutive adjustments of starting levels occur at least the threshold amount of usage apart. a pressure generator configured to generate a pressurized flow for delivery to the airway of the subject during respiratory therapy, wherein the pressurized flow includes breathable gas; one or more sensors configured to generate one or more output signals conveying information related to one or more gas parameters of the pressurized flow; and one or more processors configured to execute processing modules, the processing modules comprising: a control module configured to control the pressure generator to provide the pressurized flow during a therapy session; a therapy module configured to adjust levels of one or more gas parameters of the pressurized flow; a usage module configured to gather usage information based on the provided pressurized flow; and a starting level module configured to determine a starting level of one or more gas parameters of the pressurized flow, wherein the determination is based on gathered usage information, wherein the gathered usage information corresponds to therapeutic usage of the system spanning at least a threshold amount of usage, wherein the threshold amount of usage is more than one therapy session, and wherein the gathered usage information pertains to a predetermined percentile of the pressure level of the generated pressurized flow, a predetermined range of percentiles of the pressure level of the generated pressurized flow, and/or another statistical metric based on the pressure level of the generated pressurized flow; wherein the therapy module is further configured to apply the starting level at a beginning of a therapy session, and wherein the starting level module is further configured to adjust the starting level of the one or more gas parameters of the pressurized flow such that consecutive adjustments of starting levels occur at least the threshold amount of usage apart. a control module configured to control the pressure generator to provide the pressurized flow during a therapy session; a therapy module configured to adjust levels of one or more gas parameters of the pressurized flow; a usage module configured to gather usage information based on the provided pressurized flow; and a starting level module configured to determine a starting level of one or more gas parameters of the pressurized flow, wherein the determination is based on gathered usage information, wherein the gathered usage information corresponds to therapeutic usage of the system spanning at least a threshold amount of usage, wherein the threshold amount of usage is more than one therapy session, and wherein the gathered usage information pertains to a predetermined percentile of the pressure level of the generated pressurized flow, a predetermined range of percentiles of the pressure level of the generated pressurized flow, and/or another statistical metric based on the pressure level of the generated pressurized flow; wherein the therapy module is further configured to apply the starting level at a beginning of a therapy session, and wherein the starting level module is further configured to adjust the starting level of the one or more gas parameters of the pressurized flow such that consecutive adjustments of starting levels occur at least the threshold amount of usage apart.