A donepezil transdermal patch, comprising: (a) a backing layer, and (b) a pressure sensitive adhesive matrix layer, comprising: (i) donepezil free base in non-crystalline form; (ii) an acrylate pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, wherein 2-ethylhexyl acrylate is present in an amount of about 65% to about 75%, vinyl acetate is present in an amount of about 25% to about 35%, and the hydroxyl-containing monomers are present in an amount of about 0% to about 10%, based on the total weight of the copolymer; and (iii) a permeation enhancer selected from the group consisting of lauryl lactate, isopropyl myristate, and oleic alcohol; wherein the donepezil free base is present in an amount of about 1 % to about 15%, the acrylic pressure sensitive adhesive agent is present in an amount of about 50% to about 99%, and the permeation enhancer is present in an amount of about 1% to about 10%, based on the total weight of the pressure sensitive adhesive matrix layer. (a) a backing layer, and (b) a pressure sensitive adhesive matrix layer, comprising: (i) donepezil free base in non-crystalline form; (ii) an acrylate pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, wherein 2-ethylhexyl acrylate is present in an amount of about 65% to about 75%, vinyl acetate is present in an amount of about 25% to about 35%, and the hydroxyl-containing monomers are present in an amount of about 0% to about 10%, based on the total weight of the copolymer; and (iii) a permeation enhancer selected from the group consisting of lauryl lactate, isopropyl myristate, and oleic alcohol; wherein the donepezil free base is present in an amount of about 1 % to about 15%, the acrylic pressure sensitive adhesive agent is present in an amount of about 50% to about 99%, and the permeation enhancer is present in an amount of about 1% to about 10%, based on the total weight of the pressure sensitive adhesive matrix layer. (i) donepezil free base in non-crystalline form; (ii) an acrylate pressure sensitive adhesive agent selected from the group consisting of a copolymer of 2-ethylhexyl acrylate and vinyl acetate and a copolymer of 2-ethylhexyl acrylate, vinyl acetate, and hydroxyl-containing monomers, wherein 2-ethylhexyl acrylate is present in an amount of about 65% to about 75%, vinyl acetate is present in an amount of about 25% to about 35%, and the hydroxyl-containing monomers are present in an amount of about 0% to about 10%, based on the total weight of the copolymer; and (iii) a permeation enhancer selected from the group consisting of lauryl lactate, isopropyl myristate, and oleic alcohol; wherein the donepezil free base is present in an amount of about 1 % to about 15%, the acrylic pressure sensitive adhesive agent is present in an amount of about 50% to about 99%, and the permeation enhancer is present in an amount of about 1% to about 10%, based on the total weight of the pressure sensitive adhesive matrix layer.