mhurhangee/ep-ind-claims huggingface dataset:
A composition for use in treating a subject having a nucleotide repeat expansion disorder, wherein said nucleotide repeat expansion disorder is characterized by expansion of a nucleotide repeat in a gene of interest, said composition comprising: at least a first nucleic acid encoding a first engineered nuclease and a second nucleic acid encoding a second engineered nuclease, wherein said first engineered nuclease and said second engineered nuclease are expressible in target cells in vivo; wherein said first engineered nuclease recognizes and cleaves a first recognition sequence positioned 5' upstream of said nucleotide repeat in said gene of interest; and wherein said second engineered nuclease recognizes and cleaves a second recognition sequence positioned 3' downstream of said nucleotide repeat in said gene of interest; and wherein an intervening DNA fragment between said first recognition sequence and said second recognition sequence is excised and the number of said nucleotide repeat is reduced in said gene of interest; and wherein said first engineered nuclease and said second engineered nuclease generate complementary overhangs which promote direct re-ligation of said gene of interest.
A mask system (10, 210) comprising: a headgear and cushion module; and a seal and frame module provided to the headgear and cushion module, the seal and frame module including a sealing portion (51, 551) adapted to form a seal with the patient's face and a frame portion adapted to form a breathing chamber; and the headgear and cushion module including a cushion region (30, 330, 430, 530, 630) adapted to support and shape the sealing portion (51, 551) and a headgear region adapted to support and stabilize the mask system on the patient's face; the mask system being characterized in that the headgear and cushion module includes a composite including an outer fabric layer (25, 325, 625) that provides an exterior surface of the module, the cushion region (30, 330, 430, 530, 630) including a cushioning component (31, 632) within the fabric layer (25, 325, 625); and in that the sealing portion (51, 551) of the seal and frame module includes a first side and a second side opposite to the first side, the first side providing a sealing surface adapted to engage the patient's face and provide the seal, and the second side providing a channel to receive the cushion region (30, 330, 430, 530, 630) of the headgear and cushion module and to maintain the position of the cushion region (30, 330, 430, 530, 630). a headgear and cushion module; and a seal and frame module provided to the headgear and cushion module, the seal and frame module including a sealing portion (51, 551) adapted to form a seal with the patient's face and a frame portion adapted to form a breathing chamber; and the headgear and cushion module including a cushion region (30, 330, 430, 530, 630) adapted to support and shape the sealing portion (51, 551) and a headgear region adapted to support and stabilize the mask system on the patient's face; the mask system being characterized in that the headgear and cushion module includes a composite including an outer fabric layer (25, 325, 625) that provides an exterior surface of the module, the cushion region (30, 330, 430, 530, 630) including a cushioning component (31, 632) within the fabric layer (25, 325, 625); and in that the sealing portion (51, 551) of the seal and frame module includes a first side and a second side opposite to the first side, the first side providing a sealing surface adapted to engage the patient's face and provide the seal, and the second side providing a channel to receive the cushion region (30, 330, 430, 530, 630) of the headgear and cushion module and to maintain the position of the cushion region (30, 330, 430, 530, 630).
A vacuum cleaner, comprising: a tank defining an interior space; a vacuum pump arranged to draw a vacuum in the interior space; a plurality of accessory receivers (20, 20a, 20b), each accessory receiver (20, 20a, 20b) arranged to selectively and detachably receive a vacuum accessory; and a cord retainer (12, 12a) for receiving a cord, characterized in that the cord retainer (12, 12a) is arranged to be selectively and detachably coupled to each one of the plurality of accessory receivers (20, 20a, 20b) separately by a friction fit. a tank defining an interior space; a vacuum pump arranged to draw a vacuum in the interior space; a plurality of accessory receivers (20, 20a, 20b), each accessory receiver (20, 20a, 20b) arranged to selectively and detachably receive a vacuum accessory; and a cord retainer (12, 12a) for receiving a cord, characterized in that the cord retainer (12, 12a) is arranged to be selectively and detachably coupled to each one of the plurality of accessory receivers (20, 20a, 20b) separately by a friction fit.
A composition consisting of microparticles, wherein the microparticles consist of polyinosinic-polycytidylic acid (Poly(I:C)) and a starch carrier polymer.
A method for operating a magnetic levitation railway which contains a track (2, 3) and a magnetic levitation vehicle with a plurality of levitation magnets (20a... 20j) and support skids assigned thereto, wherein the magnetic levitation vehicle is held in a floating state by means of the levitation magnets (20a... 20j)while travelling along the track (2, 3), lowered at destinations by disconnecting the levitation magnets (20a... 20j) by means of the support skids on the track (2, 3) and gradually slowed down before the destination is reached, wherein the slowing down is brought about or assisted simply in that at least one of the levitation magnets (20a... 20j) is disconnected before the destination is reached and the magnetic levitation vehicle is lowered by means of the support skids assigned to this levitation magnet (20a... 20j) on the track (2, 3) and brought to a standstill at the destination using the frictional forces thereby created, characterized in that the frictional forces required in order to reach the destination are produced by the number of support skids on which the magnetic levitation vehicle is lowered and the times at which this takes place, wherein production of the frictional forces takes place depending on the speed of the magnetic levitation vehicle and its distance from the destination.
Apparatus for cleaning a borehole, having: - an intake channel, - a filter element, - a pump, and - an outlet channel, wherein: - the pump has an intake side and an outlet side, - the intake channel is connected to the filter element for a flow connection, - the filter element is connected to the intake side of the pump for a flow connection, - the outlet side of the pump is connected to the outlet channel for a flow connection, - the intake channel has at least one suction nozzle for sucking in drilling dust from the borehole, and - the outlet channel has at least one blowing nozzle for swirling up drilling dust in the borehole, characterized in that - the blowing nozzle is of flexible form at a free end. - an intake channel, - a filter element, - a pump, and - an outlet channel, - the pump has an intake side and an outlet side, - the intake channel is connected to the filter element for a flow connection, - the filter element is connected to the intake side of the pump for a flow connection, - the outlet side of the pump is connected to the outlet channel for a flow connection, - the intake channel has at least one suction nozzle for sucking in drilling dust from the borehole, and - the outlet channel has at least one blowing nozzle for swirling up drilling dust in the borehole, - the blowing nozzle is of flexible form at a free end.
A hinge tab of a hinge for connecting a leaf to a frame so as to be hinged about a hinge axis, having at least one assembly part (1, 2) which can be assembled on the leaf or on the frame, and having at least one hinge part (6, 7) which can be assembled on the assembly part (1, 2), wherein one of the assembly part (1, 2) and the hinge part (6, 7) comprises an undercut groove with a longitudinal axis as well as a threaded bore which defines a rotational axis, wherein the longitudinal axis and the rotational axis extend parallel to the hinge axis, wherein an adjustment spindle which is screwed into the threaded bore is provided with an end face designed as a support surface, wherein the other of the assembly part (1, 2) and the hinge part (6, 7) comprises a protrusion, which engages into the groove, and a contact surface, which can be brought into contact with the support surface, characterized in that two assembly parts (1, 2) spaced apart from each other in the direction of the hinge axis and two hinge parts (6, 7) spaced apart from each other in the direction of the hinge axis are provided, wherein each hinge part (6, 7) comprises a mounting (8, 9) for a hinge bolt defining the hinge axis, wherein the hinge bolt is formed divided into two longitudinal sections (11, 12) with ends facing each other (13, 14) in a plane extending transversely to the hinge axis, and the ends facing each other (13, 14) are in positive locking. having at least one assembly part (1, 2) which can be assembled on the leaf or on the frame, and having at least one hinge part (6, 7) which can be assembled on the assembly part (1, 2), wherein one of the assembly part (1, 2) and the hinge part (6, 7) comprises an undercut groove with a longitudinal axis as well as a threaded bore which defines a rotational axis, wherein the longitudinal axis and the rotational axis extend parallel to the hinge axis, wherein an adjustment spindle which is screwed into the threaded bore is provided with an end face designed as a support surface, wherein the other of the assembly part (1, 2) and the hinge part (6, 7) comprises a protrusion, which engages into the groove, and a contact surface, which can be brought into contact with the support surface, characterized in that two assembly parts (1, 2) spaced apart from each other in the direction of the hinge axis and two hinge parts (6, 7) spaced apart from each other in the direction of the hinge axis are provided, wherein each hinge part (6, 7) comprises a mounting (8, 9) for a hinge bolt defining the hinge axis, wherein the hinge bolt is formed divided into two longitudinal sections (11, 12) with ends facing each other (13, 14) in a plane extending transversely to the hinge axis, and the ends facing each other (13, 14) are in positive locking.
A communication mode selection method, wherein the method comprises: transmitting, in a first communication mode, an vehicle to everything, V2X, service between a leading vehicle and a following vehicle that are in a vehicle platoon, wherein the first communication mode is a direct communication mode; obtaining, by the leading vehicle, signal quality of the first communication mode; and when the signal quality of the first communication mode meets a first preset condition, obtaining, by the leading vehicle, a service type of the V2X service; and if the service type of the V2X service is a first service type, sending, by the leading vehicle, a configuration instruction to the following vehicle, wherein the configuration instruction is used to instruct the following vehicle to enable a second communication mode to communicate with the leading vehicle, and the second communication mode is a communication mode in which a network device performs forwarding. transmitting, in a first communication mode, an vehicle to everything, V2X, service between a leading vehicle and a following vehicle that are in a vehicle platoon, wherein the first communication mode is a direct communication mode; obtaining, by the leading vehicle, signal quality of the first communication mode; and when the signal quality of the first communication mode meets a first preset condition, obtaining, by the leading vehicle, a service type of the V2X service; and if the service type of the V2X service is a first service type, sending, by the leading vehicle, a configuration instruction to the following vehicle, wherein the configuration instruction is used to instruct the following vehicle to enable a second communication mode to communicate with the leading vehicle, and the second communication mode is a communication mode in which a network device performs forwarding.
A ternary oxide based composite cathode material for a lithium-sulfur battery, comprising: sulfur and LiNi 0.8 Co 0.15 Al 0.05 O 2 or LiNi x Co y Mn 1-x-y O 2 (0<x<1, 0<y<1, 0<x+y<1) as a host, wherein a sulfur content is 50 wt.%-80 wt.%.
A fuel supply manifold assembly for a gas turbine engine, the fuel supply manifold assembly comprising: a plurality of fuel supply tubes (53; 54); a fitting connecting at least two members of the plurality of fuel supply tubes; a bracket attached to the fitting; characterised in that the fuel supply manifold assembly further comprises: a bearing housing including a ball bearing; a bushing attachable to a diffuser case of the gas turbine engine, wherein the bushing is surrounded by the ball bearing; and a removable fastener to connect the bearing housing to the bracket. a plurality of fuel supply tubes (53; 54); a fitting connecting at least two members of the plurality of fuel supply tubes; a bracket attached to the fitting; characterised in that the fuel supply manifold assembly further comprises: a bearing housing including a ball bearing; a bushing attachable to a diffuser case of the gas turbine engine, wherein the bushing is surrounded by the ball bearing; and a removable fastener to connect the bearing housing to the bracket. a bearing housing including a ball bearing; a bushing attachable to a diffuser case of the gas turbine engine, wherein the bushing is surrounded by the ball bearing; and a removable fastener to connect the bearing housing to the bracket.
A seating load detecting device including a band shaped first film formed by a plurality of portions to be contacted, each portion being separated with a distance from each other forming a pressure sensitive switch for detecting a seating state of an occupant of a seat and a switch connecting wiring connecting the plurality of portions to be contacted, a band shaped second film disposed facing to the first film and formed by a plurality of portions to contact forming the pressure sensitive switch and contacting with or separating from the corresponding plurality of portions to be contacted and a partition member disposed between the first and the second films and formed with a plurality of penetration holes positioned opposite to the plurality of pressure sensitive switches and an air passage communicating with the plurality of penetrating holes and exposed to the atmosphere, wherein the first and the second films (14, 16), between which the partition member is interposed are attached to a seating surface of the seat under the films being bent, and wherein the partition member includes a relief hole provided between a bent portion formed by the first and the second films when attached to the seating surface of the seat and one of the plurality of pressure sensitive switches positioned closest to the bent portion for absorbing a strain generated due to a perimeter difference between the first and the second films.
A computer-implemented seismic imaging method that comprises: obtaining at least one shot gather for a survey region; performing reverse time migration of the shot gather, using 3D TTI equations, to determine horizontal stresses, parallel to formation layer boundaries, and vertical stresses, perpendicular to formation layer boundaries, of formation layers throughout a survey region while accounting for formations having tilted transverse isotropy; and constructing an image based at least in part on said horizontal and vertical stresses. obtaining at least one shot gather for a survey region; performing reverse time migration of the shot gather, using 3D TTI equations, to determine horizontal stresses, parallel to formation layer boundaries, and vertical stresses, perpendicular to formation layer boundaries, of formation layers throughout a survey region while accounting for formations having tilted transverse isotropy; and constructing an image based at least in part on said horizontal and vertical stresses.
A driving support method for controlling a controller to start an own vehicle by following a preceding vehicle existing in front of the own vehicle, comprising: acquiring an elapsed time from a stop of the own vehicle or a detection of a start request of the own vehicle to a start of the preceding vehicle; setting a timing to start the own vehicle based on the elapsed time, wherein the timing in case that the elapsed time is long is later than the timing in case that the elapsed time is short; and starting the own vehicle at the timing; characterized in that a rate of change in acceleration of the own vehicle in case that the elapsed time is long is set smaller than a rate of change in acceleration of the own vehicle in case that the elapsed time is short. acquiring an elapsed time from a stop of the own vehicle or a detection of a start request of the own vehicle to a start of the preceding vehicle; setting a timing to start the own vehicle based on the elapsed time, wherein the timing in case that the elapsed time is long is later than the timing in case that the elapsed time is short; and starting the own vehicle at the timing; characterized in that a rate of change in acceleration of the own vehicle in case that the elapsed time is long is set smaller than a rate of change in acceleration of the own vehicle in case that the elapsed time is short.
A method, comprising: determining, at a first metering component on a host of a provider network comprising a plurality of hosts (105A, 105B), networking metadata comprising (a) endpoint address information and (b) a traffic metric, wherein the networking metadata is associated with one or more network transmissions for which at least one endpoint comprises a virtualized resource (114A-C) instantiated at the host; aggregating networking metadata, received from at least the first metering component, at a second metering component in accordance with an aggregation policy; generating, at a traffic classification node of the provider network, one or more categorized usage records corresponding to the one or more network transmissions, based at least in part on aggregated networking metadata obtained from at least the second metering component and based at least in part on a representation of a network topology associated with the provider network; and determining, at a billing node and using the one or more categorized usage records, a billing amount to be charged for the one or more network transmissions. determining, at a first metering component on a host of a provider network comprising a plurality of hosts (105A, 105B), networking metadata comprising (a) endpoint address information and (b) a traffic metric, wherein the networking metadata is associated with one or more network transmissions for which at least one endpoint comprises a virtualized resource (114A-C) instantiated at the host; aggregating networking metadata, received from at least the first metering component, at a second metering component in accordance with an aggregation policy; generating, at a traffic classification node of the provider network, one or more categorized usage records corresponding to the one or more network transmissions, based at least in part on aggregated networking metadata obtained from at least the second metering component and based at least in part on a representation of a network topology associated with the provider network; and determining, at a billing node and using the one or more categorized usage records, a billing amount to be charged for the one or more network transmissions.
Dose setting mechanism for a drug delivery device, preferably a resettable drug delivery device, the mechanism comprising: a dose setting member, a drive member, for driving a piston rod in a distal direction during dose dispensing, the drive member comprising a proximal drive member (4") and a distal drive member, a first clutch for releasably coupling the proximal drive member (4") and the distal drive member, spring means for biasing the proximal drive member (4") and the distal drive member in the coupled state during dose setting and dose dispensing, and engaging means (3a, 4a) associated to the proximal drive member (4") and to the dose setting member, characterized in that the engaging means (3a, 4a) comprise hooks provided on fingers protruding from the proximal end of the proximal drive member (4") and a corresponding inwardly protruding flange on the proximal end of the dose setting member such that the proximal drive member (4") entrains the dose setting member in the distal direction during dose dispensing but allows a relative axial movement of the proximal drive member (4") with respect to the dose setting member in the proximal direction. a dose setting member, a drive member, for driving a piston rod in a distal direction during dose dispensing, the drive member comprising a proximal drive member (4") and a distal drive member, a first clutch for releasably coupling the proximal drive member (4") and the distal drive member, spring means for biasing the proximal drive member (4") and the distal drive member in the coupled state during dose setting and dose dispensing, and engaging means (3a, 4a) associated to the proximal drive member (4") and to the dose setting member, characterized in that the engaging means (3a, 4a) comprise hooks provided on fingers protruding from the proximal end of the proximal drive member (4") and a corresponding inwardly protruding flange on the proximal end of the dose setting member such that the proximal drive member (4") entrains the dose setting member in the distal direction during dose dispensing but allows a relative axial movement of the proximal drive member (4") with respect to the dose setting member in the proximal direction.
A fuel cell including two bipolar plates and an electrode membrane assembly sandwiched between these bipolar plates, each bipolar plate including a peripheral frame and a central area for distribution of the reagents, the electrode membrane assembly comprising an active zone having a layer of anode or cathode diffusion (71a, 73a) which is the site of the anode and cathode reactions, and a peripheral frame, a seal being affixed between a bipolar plate and the electrode membrane assembly, said seal being in the form of a membrane, the profile of which corresponds to the peripheral frame of the bipolar plate and comprising a central opening coinciding with the central area for distribution of the reagents of the bipolar plate, characterized in that the seal comprises a rebate at the level of the inner framing rim of the central opening on which the anode or cathode diffusion layer (71a, 73a) at least partly bears on assembling of the cell whilst also bearing on the bipolar plate at the level of its central zone; and in that this seal also comprises a front face on which the peripheral frame of the assembly bears.