mhurhangee/ep-ind-claims huggingface dataset:
A method for preparing therapeutically active fusion protein, wherein the fusion protein comprises a tumor targeting moiety and at least one immunomodulatory molecule that counteracts immune tolerance of a cancer cell, wherein the tumor targeting moiety is an antibody that binds to EGFR1 or CTLA-4 and wherein the fusion protein is prepared by the following steps: preparing a codon optimized nucleotide sequence encoding the fusion protein for expression in CHO cells, wherein the codon optimized nucleotide sequence is modified to increase CG sequences, and wherein the codon optimized nucleotide sequence is SEQ ID NO: 1 or 5 for the heavy chain of the antibody, SEQ ID NO: 2 or 6 for the light chain of the antibody, SEQ ID NO: 3 or 7 for immunomodulatory molecule, wherein the codon optimized nucleotide sequence SEQ ID NO: 1 or 5 for the heavy chain of the antibody that binds to EGFR1 or CTLA-4, respectively is lacking nucleotides for expression of a lysine at the C-terminal end of the heavy chain of the antibody; cloning the optimized sequence of said fusion protein in the CHO cells capable of transient or stable expression; growing the CHO cells in a media under suitable conditions for growing and allowing the host cell to express the fusion protein; and collecting secreted fusion proteins and optionally for further purification. preparing a codon optimized nucleotide sequence encoding the fusion protein for expression in CHO cells, wherein the codon optimized nucleotide sequence is modified to increase CG sequences, and wherein the codon optimized nucleotide sequence is SEQ ID NO: 1 or 5 for the heavy chain of the antibody, SEQ ID NO: 2 or 6 for the light chain of the antibody, SEQ ID NO: 3 or 7 for immunomodulatory molecule, wherein the codon optimized nucleotide sequence SEQ ID NO: 1 or 5 for the heavy chain of the antibody that binds to EGFR1 or CTLA-4, respectively is lacking nucleotides for expression of a lysine at the C-terminal end of the heavy chain of the antibody; cloning the optimized sequence of said fusion protein in the CHO cells capable of transient or stable expression; growing the CHO cells in a media under suitable conditions for growing and allowing the host cell to express the fusion protein; and collecting secreted fusion proteins and optionally for further purification.
A search apparatus, comprising a global dispatcher, a global arbiter, and N search engines, wherein N is an integer greater than 1, the N search engines can access a first search table, each search engine can access only one subtable of the first search table, for any two subtables N1 and N2 of the first search table, any entry in the subtable N1 is different from any entry in the subtable N2, and the first search table is corresponding to a first search algorithm; the global dispatcher is configured to: determine that a first search keyword is corresponding to the first search table, determine that the first search table is corresponding to the N search engines, and dispatch the first search keyword to the N search engines; each search engine in the N search engines is configured to: search, according to the first search algorithm, the one subtable that is of the first search table and can be accessed by each search engine in the N search engines, to determine whether an entry that matches the first search keyword dispatched by the global dispatcher exists; and output a search result to the global arbiter; and the global arbiter is configured to arbitrate the search result output by each search engine, to obtain a search result corresponding to the first search table.
A multi-functional keypad comprising a keypad body and a composite hinge assembly; the composite hinge assembly comprising: a clamping portion and a rotating shaft portion fixed relative to the clamping portion and extending out of the two ends of the clamping portion, the clamping portion having an inner surface defining a slot configured for receiving a part of a tablet computer and an outer surface which is a damping layer made of an elastic material; the composite hinge assembly being rotatably disposed on the keypad body by means of the rotating shaft portion at the two ends; characterized by: the damping layer being configured to be pressed and to come into elastic contact with the keypad body as the clamping portion is rotated about the rotating shaft portion relative to the keypad body, so that the tablet computer is stably disposed at any desired opening angle; and the outer surface of the clamping portion being a cam surface centered on the rotating shaft portion; wherein as the clamping portion is rotated to a larger angle, the damping layer is configured to be pressed to a larger extent, such that the pressing force is offset by the turning force generated by the gravity of the tablet computer to achieve a stable positioning. the damping layer being configured to be pressed and to come into elastic contact with the keypad body as the clamping portion is rotated about the rotating shaft portion relative to the keypad body, so that the tablet computer is stably disposed at any desired opening angle; and the outer surface of the clamping portion being a cam surface centered on the rotating shaft portion; wherein as the clamping portion is rotated to a larger angle, the damping layer is configured to be pressed to a larger extent, such that the pressing force is offset by the turning force generated by the gravity of the tablet computer to achieve a stable positioning.
An electrically peelable pressure-sensitive adhesive sheet (1a, 1b, 1c, 1d, 2a, 2b) comprising an electrically conductive substrate having a support, an intermediate layer, and an electrically conductive layer in this order, a first pressure-sensitive adhesive layer having electrical peelability laminated on a side of the electrically conductive layer of the electrically conductive substrate, and a second pressure-sensitive adhesive layer laminated on a side of the support, wherein the electrically conductive substrate has substantially no extension portion elongating and exposed more than the first pressure-sensitive adhesive layer and the second pressure-sensitive adhesive layer in a surface extending direction of the electrically conductive substrate, wherein at least part of the intermediate layer comprises an electrically conductive pressure-sensitive adhesive layer, and wherein the terms "has substantially no extension portion" and "electrical peelability" are as defined in the description. wherein the electrically conductive substrate has substantially no extension portion elongating and exposed more than the first pressure-sensitive adhesive layer and the second pressure-sensitive adhesive layer in a surface extending direction of the electrically conductive substrate, wherein at least part of the intermediate layer comprises an electrically conductive pressure-sensitive adhesive layer, and wherein the terms "has substantially no extension portion" and "electrical peelability" are as defined in the description.
A method performed by a user agent, UA, in an evolved packet system, EPS, comprising: upon initiation of a circuit-switched, CS, fallback service, identifying, by a non-access stratum, NAS, protocol layer, a type of the CS fallback service; determining, by the NAS protocol layer, a radio resource control, RRC, establishment cause, EC, based on the type of the CS fallback service; and providing the RRC EC to an access stratum, AS, protocol layer, wherein when the type of the CS fallback service is mobile originating, MO, CS fallback emergency call, the RRC EC is set to emergency call. upon initiation of a circuit-switched, CS, fallback service, identifying, by a non-access stratum, NAS, protocol layer, a type of the CS fallback service; determining, by the NAS protocol layer, a radio resource control, RRC, establishment cause, EC, based on the type of the CS fallback service; and providing the RRC EC to an access stratum, AS, protocol layer, wherein when the type of the CS fallback service is mobile originating, MO, CS fallback emergency call, the RRC EC is set to emergency call.
Stable liquid ingredient composition comprising oleyl lactylate and/or salts thereof and a further lactylate selected from lauroyl lactylate and/or salts thereof or a mixture of lauroyl lactylate and myristoyl lactylate and/or their salts (LL/ML-blend).
A sound reproduction system comprising a front horn in communication with a speaker driver, a front acoustical chamber, a rear acoustical chamber and a feed-back duct, wherein the front chamber is in communication with the front horn, characterized by a ring resonator duct, whereby the rear acoustical chamber is in communication with the ring resonator duct which connects the rear acoustical chamber with itself thereby forming a continuous loop duct and which is in communication with the front horn by means of the feedback duct.
Medical fastening device for a sensor with a clamping element and with a sensor mount, wherein the clamping element has a counterpiece and a pressing piece movable relative to the counterpiece, wherein the counterpiece has a lateral opening, which frees a free mounting area, wherein the counterpiece encloses the mounting area at least partially in a framelike manner, wherein the counterpiece has a depression, which points towards the mounting area and which is arranged opposite the pressing piece, wherein the counterpiece is provided with an opening arranged opposite the depression, and wherein the pressing piece is movable in the opening in the direction of the depression of the counterpiece, wherein the fastening device is configured for receiving an electromagnetic sensor, wherein a sensor mount is provided, the pressing piece has a carriage and a screwed part, characterized in that the carriage is connected to the screwed part in a positive-locking manner and is mounted rotatably at the screwed part and that moreover, the carriage has a groove having a circle segment-shaped section on its end face facing the depression of the counterpiece.
A method for wireless communications by a first device, comprising: obtaining, via an ultrasonic or near-ultrasonic signal, identification information and information indicating one or more capabilities of a second device; using the identification information to establish a connection with said second device via a radio frequency interface; obtaining a selection by a user of the first device of one or more of the indicated one or more capabilities of the second device; and transferring data, based on the information indicating one or more capabilities of the second device and the selected one or more capabilities of the second device, between the first and second devices via the radio frequency Interface. obtaining, via an ultrasonic or near-ultrasonic signal, identification information and information indicating one or more capabilities of a second device; using the identification information to establish a connection with said second device via a radio frequency interface; obtaining a selection by a user of the first device of one or more of the indicated one or more capabilities of the second device; and transferring data, based on the information indicating one or more capabilities of the second device and the selected one or more capabilities of the second device, between the first and second devices via the radio frequency Interface.
Method for disconnecting a first mechanical part from a magnetic second mechanical part, the first mechanical part being adhered to the magnetic second mechanical part by means of an adhesive film along a connecting area, method wherein a magnetic field is generated, at least in the connecting area, so as to generate by induction eddy current in the magnetic second mechanical part in order to soften the adhesive film and enable the disconnecting of the mechanical parts (4, 1).
An engine system (10, 10') comprising a hydrogen combustion engine and an exhaust aftertreatment system, EATS (20, 20'), configured to reduce emissions of the engine exhausts, wherein the EATS (20, 20') comprises: - an exhaust gas inlet for receiving engine exhaust from the hydrogen combustion engine; - a plurality of emission reducing modules arranged downstream of the exhaust gas inlet and being configured to reduce emissions of the engine exhausts, the plurality of emission reducing modules comprising at least: - a first emission reducing module with a porous substrate having an inlet face and an outlet face, the porous substrate comprising inlet channels extending from the inlet face, and outlet channels extending from the outlet face; the inlet channels and the outlet channels being separated by a plurality of filter walls (42a, 42b, 42c) having a porous structure; the porous structure of the filter walls (42a, 42b, 42c) and/or the outlet channels of the porous substrate being loaded with a selective catalyst reduction, SCR, catalyst coating (49a, 49b); - a second emission reducing module being a selective catalyst reduction, SCR, catalyst unit; wherein one of the first and second emission reducing modules (40, 50) is arranged as the first occurring emission reducing module of the EATS (20, 20') downstream of the exhaust gas inlet, characterized by that the inlet channels of the porous substrate is loaded with a powder coating configured to filter particles from the engine exhaust. - an exhaust gas inlet for receiving engine exhaust from the hydrogen combustion engine; - a plurality of emission reducing modules arranged downstream of the exhaust gas inlet and being configured to reduce emissions of the engine exhausts, the plurality of emission reducing modules comprising at least: - a first emission reducing module with a porous substrate having an inlet face and an outlet face, the porous substrate comprising inlet channels extending from the inlet face, and outlet channels extending from the outlet face; the inlet channels and the outlet channels being separated by a plurality of filter walls (42a, 42b, 42c) having a porous structure; the porous structure of the filter walls (42a, 42b, 42c) and/or the outlet channels of the porous substrate being loaded with a selective catalyst reduction, SCR, catalyst coating (49a, 49b); - a second emission reducing module being a selective catalyst reduction, SCR, catalyst unit; - a first emission reducing module with a porous substrate having an inlet face and an outlet face, the porous substrate comprising inlet channels extending from the inlet face, and outlet channels extending from the outlet face; the inlet channels and the outlet channels being separated by a plurality of filter walls (42a, 42b, 42c) having a porous structure; the porous structure of the filter walls (42a, 42b, 42c) and/or the outlet channels of the porous substrate being loaded with a selective catalyst reduction, SCR, catalyst coating (49a, 49b); - a second emission reducing module being a selective catalyst reduction, SCR, catalyst unit;
A refrigerant amount determining device configured to determine 2 the refrigerant amount of an air conditioning system comprising: an operation data acquiring unit configured to acquire operation data of an air conditioning system; a calculating unit configured to calculate a refrigerant amount index value being an indicative value of the refrigerant amount correlating with the refrigerant amount from the operation data acquired; an inferring unit configured to infer information regarding correction of the refrigerant amount index value using a correction model and at least one of the acquired operation data or the calculated refrigerant amount index value; and a determining unit configured to determine a refrigerant amount of the air conditioning system based on the information regarding correction of the refrigerant amount index value. an operation data acquiring unit configured to acquire operation data of an air conditioning system; a calculating unit configured to calculate a refrigerant amount index value being an indicative value of the refrigerant amount correlating with the refrigerant amount from the operation data acquired; an inferring unit configured to infer information regarding correction of the refrigerant amount index value using a correction model and at least one of the acquired operation data or the calculated refrigerant amount index value; and a determining unit configured to determine a refrigerant amount of the air conditioning system based on the information regarding correction of the refrigerant amount index value.
A vibration reduction apparatus for a power hammer apparatus comprising a housing, a motor arranged in the housing, a piston (520; 620; 1120) adapted to be caused by the motor to execute reciprocating motion in a bore, and a flying mass (569; 1169) arranged in the bore such that said reciprocating motion of said piston (520; 620; 1120) in said bore in use causes reciprocating motion of said flying mass (569; 1169) relative to the housing to impart impacts to a working member of the hammer apparatus, the vibration reduction apparatus comprising:- at least one driveable mass (521; 621; 1121) adapted to at least partially surround at least part of the bore, wherein at least one said driveable mass (521; 621; 1121) is adapted to be caused by the motor to execute reciprocating motion to at least partially cancel vibration of said housing caused by reciprocating motion of the flying mass (569; 1169) relative to the housing; at least one driving gear adapted to be driven by said motor to cause said reciprocating motion of said piston (520; 620; 1120) and to cause said reciprocating motion of at least one said driveable mass (521; 621; 1121); cam means (533; 633; 1133) rotatable by means of at least one said driving gear and adapted to engage at least one said drivable mass (521; 621; 1121); characterised in that there is first biasing means (535; 1187) for urging at least one said drivable mass (521; 621; 1121) into engagement with said cam means (533; 633; 1133).
A crop residue management apparatus for flexible distribution of straw and chaff contained within the crop residue, said apparatus comprising: a pair of laterally spaced spreader devices for distributing a crop residue laterally; a duct for directing a crop residue stream to said spreader devices in a downward direction toward said laterally spaced spreader devices; and, a swath chute displaceable between a first position in which the swath chute is out of the crop residue stream and a second position in which it directs straw in the residue stream in a windrow behind said apparatus and directs chaff laterally, wherein the swath chute has a bottom portion converging in a downstream direction and sidewalls extending from the bottom section, the swath chute including a deflector (62, 64) connected to the bottom of the bottom portion to deflect chaff from the spreaders in a lateral direction characterized in that the spreader devices are circular disks and the deflector (62, 64) extending from the bottom of the bottom portion is curved to conform to the curving of the disks. a pair of laterally spaced spreader devices for distributing a crop residue laterally; a duct for directing a crop residue stream to said spreader devices in a downward direction toward said laterally spaced spreader devices; and, a swath chute displaceable between a first position in which the swath chute is out of the crop residue stream and a second position in which it directs straw in the residue stream in a windrow behind said apparatus and directs chaff laterally, wherein the swath chute has a bottom portion converging in a downstream direction and sidewalls extending from the bottom section, the swath chute including a deflector (62, 64) connected to the bottom of the bottom portion to deflect chaff from the spreaders in a lateral direction characterized in that
Device, comprising: - a mould container with at least one mould cavity, wherein the mould cavity is bounded by a bottom and at least one wall; - at least one ejector per mould cavity, comprising the bottom which is movable in the mould cavity for the purpose of ejecting a green brick formed in the mould cavity; and - a separator configured to release the green brick from the bottom., characterized in that - the separator comprises a division of the bottom into a first part and a second part; and - the second part is surrounded by the first part. - a mould container with at least one mould cavity, wherein the mould cavity is bounded by a bottom and at least one wall; - at least one ejector per mould cavity, comprising the bottom which is movable in the mould cavity for the purpose of ejecting a green brick formed in the mould cavity; and - a separator configured to release the green brick from the bottom., - the separator comprises a division of the bottom into a first part and a second part; and - the second part is surrounded by the first part.
A device for determining the temperature of a tubular strand conveyed out of an extrusion device, comprising a first temperature sensor for measuring a first temperature of the outer face of the tubular strand at a first position of the tubular strand, and an evaluation apparatus, characterized in that the evaluation apparatus is designed to compare the first temperature with a second temperature of the outer face of the tubular strand at a second position of the tubular strand that is at a distance from the first position in the conveying direction of the tubular strand, and to determine the temperature inside the tubular strand and/or on the inner face of the tubular strand at a position of the tubular strand from the comparison of the first and second temperature.
A solar cell comprising an organic-inorganic hybrid perovskite compound, wherein the organic-inorganic hybrid perovskite compound is represented by the following chemical formula 1 or 2: [Formula 1] AMX 3 [Formula 2] A 2 MX 4 in the above formulas, A is CD 3-a H a N + D 3-b H b, wherein a is a real number from 0 to 3, b is a real number from 0 to 3, except i) when a is 3 and b is 3, ii) when a is 3 and b is 0, or iii) when a is 0 and b is 3, M is a divalent metal ion, and X is a halogen ion. A is CD 3-a H a N + D 3-b H b, wherein a is a real number from 0 to 3, b is a real number from 0 to 3, except i) when a is 3 and b is 3, ii) when a is 3 and b is 0, or iii) when a is 0 and b is 3, M is a divalent metal ion, and X is a halogen ion.