mhurhangee/ep-ind-claims huggingface dataset:
A process, comprising: (a) forming an aqueous reaction mixture comprising: i. a source of iron ions; ii. a source of hydroxide ions; iii. at least one carboxylic acid, and wherein the at least one carboxylic acid is chosen from a monoether carboxylic acid, or an ether carboxylic acid of formula I R-O-(CH 2 CH 2 O) n CHR 1 CO 2 Y wherein: R represents hydrogen or a substituted or unsubstituted alkyl group or a substituted or unsubstituted aromatic group; R 1 represents hydrogen or an alkyl group; Y represents H or a counterion; and n is 0-5; and (b) heating or cooling the reaction mixture to a temperature in the range of 0 °C to 100 °C, thereby directly forming in the reaction mixture an aqueous dispersion of crystalline iron-containing nanoparticles; and wherein: said source of iron ions and said source of hydroxide ions are added concurrently at a molar ratio of the carboxylic acid to iron ions of greater than 2.6; or said source of iron ions is added separately to the source of hydroxide ions at a molar ratio of the carboxylic acid to iron ions of greater than 1.8. (a) forming an aqueous reaction mixture comprising: i. a source of iron ions; ii. a source of hydroxide ions; iii. at least one carboxylic acid, and wherein the at least one carboxylic acid is chosen from a monoether carboxylic acid, or an ether carboxylic acid of formula I R-O-(CH 2 CH 2 O) n CHR 1 CO 2 Y wherein: R represents hydrogen or a substituted or unsubstituted alkyl group or a substituted or unsubstituted aromatic group; R 1 represents hydrogen or an alkyl group; Y represents H or a counterion; and n is 0-5; and i. a source of iron ions; ii. a source of hydroxide ions; iii. at least one carboxylic acid, and wherein the at least one carboxylic acid is chosen from a monoether carboxylic acid, or an ether carboxylic acid of formula I R-O-(CH 2 CH 2 O) n CHR 1 CO 2 Y wherein: R represents hydrogen or a substituted or unsubstituted alkyl group or a substituted or unsubstituted aromatic group; R 1 represents hydrogen or an alkyl group; Y represents H or a counterion; and n is 0-5; and R represents hydrogen or a substituted or unsubstituted alkyl group or a substituted or unsubstituted aromatic group; R 1 represents hydrogen or an alkyl group; Y represents H or a counterion; and n is 0-5; and (b) heating or cooling the reaction mixture to a temperature in the range of 0 °C to 100 °C, thereby directly forming in the reaction mixture an aqueous dispersion of crystalline iron-containing nanoparticles; said source of iron ions and said source of hydroxide ions are added concurrently at a molar ratio of the carboxylic acid to iron ions of greater than 2.6; or said source of iron ions is added separately to the source of hydroxide ions at a molar ratio of the carboxylic acid to iron ions of greater than 1.8.
A cardiac monitoring and therapy system (214, 218), comprising: a first unit adapted for monitoring a cardiac condition of a patient via ECG monitoring circuitry and configured for providing processing or control for CPR functions, the first unit configured to provide an indication of the patient's condition and further configured to store chest compression performance data in a memory of the first unit; a second unit separate from and in communication with the first unit, the second unit comprising an energy delivery unit (172, 173, 174) and at least two high-voltage defibrillation electrodes (12, 14) operatively connected to the energy delivery unit and adapted to be placed on the patient; and a processor in communication with the at least two high-voltage defibrillation electrodes (12, 14) and configured to provide at least one of defibrillation and pacing pulses to the patient via at the least two high-voltage defibrillation electrodes, the system being configured to transfer the chest compression performance data between the memory and the second unit. a first unit adapted for monitoring a cardiac condition of a patient via ECG monitoring circuitry and configured for providing processing or control for CPR functions, the first unit configured to provide an indication of the patient's condition and further configured to store chest compression performance data in a memory of the first unit; a second unit separate from and in communication with the first unit, the second unit comprising an energy delivery unit (172, 173, 174) and at least two high-voltage defibrillation electrodes (12, 14) operatively connected to the energy delivery unit and adapted to be placed on the patient; and a processor in communication with the at least two high-voltage defibrillation electrodes (12, 14) and configured to provide at least one of defibrillation and pacing pulses to the patient via at the least two high-voltage defibrillation electrodes, the system being configured to transfer the chest compression performance data between the memory and the second unit.
An inhibitor of the ubiquitin-proteasome system for use in treating cancer in a patient, wherein the patient has been assessed to establish that the cancer is associated with tumor cells in which the functional activity of SMARCB1 is low or absent, which means a reduced or absent expression of SMARCB1 in tumor cells relative to internal positive controls in tissue samples as assessed at the protein and/or mRNA level, as well as presence of chromosomal aberrations or DNA mutations or epigenetic alterations.
Method of managing a system comprising a multitude of power sources (S1 - Sm) and power loads (L1 - Ln), configured for execution in a computing device, the computing device being assigned to the system, characterized in that the multitude of sources (S1 - Sm) and loads (PL1 - Ln) in a first step is divided into a plurality of groups of sources and loads and in at least one second step the managing of the system is executed for each group separately, wherein the grouping in the first step is executed according to at least one property of the sources and loads, in such a way that the sources and loads of each group share at least one similar property, the property for executing the grouping being a relative physical proximity of devices comprising the sources and/or loads.
Locking device with a strike plate (13, 14) for receiving a locking pin bolt (17, 18) in different positions of an espagnolette fitting with a drive equipment and with an opening (23, 33) in the strike plate (13, 14) for moving the locking pin bolt (17 - 20) in and out and with two locking edges (21, 22, 31, 32) for engaging from behind the locking pin bolt (17 - 20) in different positions of the espagnolette fitting, wherein a slider (24, 34) is slidably arranged parallel to the locking edges (21, 22) of the strike plate (13, 14) and the slider has a locking edge (25, 35), which blocks or clears the opening (23, 33) in the strike plate (13, 14) depending on a switching sequence of the drive equipment, characterized in that the slider (24, 34) has two control edges (27, 28, 37, 38), arranged orthogonally to the locking edge (25, 35) and extending into the range of movement of the locking pin bolt (17, 18), and between one of the control edges (27, 28, 37, 38) and the locking edge (25, 35) it has an opening (26, 36) for the insertion of the locking pin bolt (17, 18) and in that the blocking or clearing of the opening in the strike plate takes place in a particularly reliable manner so that operating the locking equipment in a faulty manner is prevented reliably.
A process for evacuating bottles of liquefied petroleum gas, characterised in that: - the bottle of liquefied petroleum is cooled in a bath filled with a cooled liquid to between -5 and -10°C, when it contains butane, and to between -50 and -55°C when it contains propane, - the valve is removed from the cooled bottle, a sealed device with an orifice for the injection of an inert gas is attached to the neck of the bottle and a glass tube discharging at the bottom of the bottle to expel the liquefied petroleum gas to the outside through the glass tube, - an inert gas is injected under pressure which expels the liquefied petroleum gas to the outside, - the sealed device is removed from the bottle. - the bottle of liquefied petroleum is cooled in a bath filled with a cooled liquid to between -5 and -10°C, when it contains butane, and to between -50 and -55°C when it contains propane, - the valve is removed from the cooled bottle, a sealed device with an orifice for the injection of an inert gas is attached to the neck of the bottle and a glass tube discharging at the bottom of the bottle to expel the liquefied petroleum gas to the outside through the glass tube, - an inert gas is injected under pressure which expels the liquefied petroleum gas to the outside, - the sealed device is removed from the bottle.
A rubber composition comprising: 100 parts by mass of a rubber component containing 45 to 75% by mass of natural rubber and 25 to 55% by mass of a conjugated diene-based polymer, in which a bonded styrene amount of conjugated diene compound moieties is 25% or less; 1 to 40 parts by mass of a non-modified conjugated diene-based polymer which has a weight average molecular weight of 5,000 or more but less than 40,000 in terms of polystyrene as measured by gel permeation chromatography and in which a bonded styrene amount of conjugated diene compound moieties is less than 10% and a bonded vinyl amount of conjugated diene compound moieties is 45% or more but 55% or less; and a filler, wherein at least one of the conjugated diene-based polymers contained in the rubber component is a modified conjugated diene-based polymer. 100 parts by mass of a rubber component containing 45 to 75% by mass of natural rubber and 25 to 55% by mass of a conjugated diene-based polymer, in which a bonded styrene amount of conjugated diene compound moieties is 25% or less; 1 to 40 parts by mass of a non-modified conjugated diene-based polymer which has a weight average molecular weight of 5,000 or more but less than 40,000 in terms of polystyrene as measured by gel permeation chromatography and in which a bonded styrene amount of conjugated diene compound moieties is less than 10% and a bonded vinyl amount of conjugated diene compound moieties is 45% or more but 55% or less; and a filler, wherein at least one of the conjugated diene-based polymers contained in the rubber component is a modified conjugated diene-based polymer.
A photostimulable plate reading device, comprising: at least one photostimulable plate (12; 62) carrying image data and having two opposite surfaces; illuminating means for homogeneously illuminating a first one of the two opposite surfaces of the at least one photostimulable plate (12; 62) with light emitted by one or more electroluminescent diodes in a first wavelength range, the illumination causing the at least one photostimulable plate (12; 62) both to emit light in a second wavelength range by photostimulated luminescence and to scatter light in the first wavelength range; filtering means (22; 40; 41; 64) adapted to allow substantially 1000000 times more light emitted in the second wavelength range to pass than light emitted in the first wavelength range, the filtering being formed by a block of optical fibers (30; 42; 43; 49; 66), wherein the filtering means faces a second one of the two opposite surfaces of the at least one photostimulable plate (12; 62), wherein the optical fibers are arranged within the block of optical fibers in such a manner that opposite ends of the optical fibers form two dimensional arrays at opposite ends of the block of optical fibers, and wherein each optical fiber is made of glass and has a core and an outer clad surrounding the core, the core of each fiber having a t least 35% increased metallic oxide particles with respect to the original glass to increase the refractive index of said core; and detecting means (24; 68) composed of a two dimensional array of pixels for detecting the light allowed to pass and for obtaining image data therefrom. at least one photostimulable plate (12; 62) carrying image data and having two opposite surfaces; illuminating means for homogeneously illuminating a first one of the two opposite surfaces of the at least one photostimulable plate (12; 62) with light emitted by one or more electroluminescent diodes in a first wavelength range, the illumination causing the at least one photostimulable plate (12; 62) both to emit light in a second wavelength range by photostimulated luminescence and to scatter light in the first wavelength range; filtering means (22; 40; 41; 64) adapted to allow substantially 1000000 times more light emitted in the second wavelength range to pass than light emitted in the first wavelength range, the filtering being formed by a block of optical fibers (30; 42; 43; 49; 66), wherein the filtering means faces a second one of the two opposite surfaces of the at least one photostimulable plate (12; 62), wherein the optical fibers are arranged within the block of optical fibers in such a manner that opposite ends of the optical fibers form two dimensional arrays at opposite ends of the block of optical fibers, and wherein each optical fiber is made of glass and has a core and an outer clad surrounding the core, the core of each fiber having a t least 35% increased metallic oxide particles with respect to the original glass to increase the refractive index of said core; and detecting means (24; 68) composed of a two dimensional array of pixels for detecting the light allowed to pass and for obtaining image data therefrom.
A method of controlling movement of sediment in water adjacent a shore, comprising: determining at a predetermined location where incident waves have an average incident wavelength of between 20m and 200m an average incident wavelength of waves travelling towards the shore; erecting at the predetermined location a structure on an underwater substrate, the structure presenting a substantially convex horizontal profile extending substantially around its periphery, the profile having a horizontal width of no more than about four times the average incident wavelength and no less than about half the average incident wavelength, and the structure having a height sufficient to extend above the surface of the water to enable incident waves to be at least partially reflected therefrom; and erecting a further structure on the underwater substrate, spaced from the predetermined location, the further structure presenting a substantially convex horizontal profile to waves travelling toward the shore, the profile of the further structure having a horizontal width of no more than about four times the average incident wavelength, and the further structure having a height sufficient for incident waves to be at least partially reflected therefrom, wherein the further structure is spaced from the predetermined location between three and eight times a distance of first-defined structure from the shore. determining at a predetermined location where incident waves have an average incident wavelength of between 20m and 200m an average incident wavelength of waves travelling towards the shore; erecting at the predetermined location a structure on an underwater substrate, the structure presenting a substantially convex horizontal profile extending substantially around its periphery, the profile having a horizontal width of no more than about four times the average incident wavelength and no less than about half the average incident wavelength, and the structure having a height sufficient to extend above the surface of the water to enable incident waves to be at least partially reflected therefrom; and erecting a further structure on the underwater substrate, spaced from the predetermined location, the further structure presenting a substantially convex horizontal profile to waves travelling toward the shore, the profile of the further structure having a horizontal width of no more than about four times the average incident wavelength, and the further structure having a height sufficient for incident waves to be at least partially reflected therefrom, wherein the further structure is spaced from the predetermined location between three and eight times a distance of first-defined structure from the shore.
A polishing tool holder configured to removably hold a polishing tool having a grinding element holder and a grinding element (2, 61, 71) held in the grinding element holder, the polishing tool holder comprising: a shank configured to be connected, during use of the polishing tool holder, to a spindle of a machine tool; a support mechanism configured to support the polishing tool movably in an axis direction of the shank; and a load detector configured to detect a load exerted on the polishing tool from a workpiece when the polishing tool supported by the support mechanism is polishing the workpiece; characterized in that,the polishing tool holder further comprises: a movement mechanism including a drive source to move the polishing tool in the axis direction of the shank; a control unit configured to actuate the movement mechanism based on output from the load detector to move the polishing tool in the axis direction of the shank; a first power source configured to supply power to the drive source of the movement mechanism;and a second power source configured to supply power to the control unit. a shank configured to be connected, during use of the polishing tool holder, to a spindle of a machine tool; a support mechanism configured to support the polishing tool movably in an axis direction of the shank; and a load detector configured to detect a load exerted on the polishing tool from a workpiece when the polishing tool supported by the support mechanism is polishing the workpiece; characterized in that,the polishing tool holder further comprises: a movement mechanism including a drive source to move the polishing tool in the axis direction of the shank; a control unit configured to actuate the movement mechanism based on output from the load detector to move the polishing tool in the axis direction of the shank; a first power source configured to supply power to the drive source of the movement mechanism;and a second power source configured to supply power to the control unit. a movement mechanism including a drive source to move the polishing tool in the axis direction of the shank; a control unit configured to actuate the movement mechanism based on output from the load detector to move the polishing tool in the axis direction of the shank; a first power source configured to supply power to the drive source of the movement mechanism;and a second power source configured to supply power to the control unit.
A dispensing apparatus for strips of coiled flexible material, and having at regular intervals tear lines to form the strips, said apparatus comprises a casing receiving said coil, said casing having a circular opening for the passage and distribution of a strip under a tensile stress, the apparatus comprising washers fastened on the casing concentrically with the distribution opening, the internal diameters of the washers being smaller than the diameter of the opening, said washers being made of an elastomeric material capable of being deformed under the effect of the material distribution through said opening for achieving, concomitantly, a strip cut according to a tear line, characterised in that said washers cooperate with an element manually operable to reduce at will the exit space formed through the internal diameters of the washers and said operable element, and in that either the superimposed washers are made of elastomer and with an internal diameter decreasing towards the strip dispensing direction, so as to create a cone effect, or a washer of rigid material is interposed between the elastomeric washers, whose internal diameter is at least equal to the diameter of the dispensing opening.
A compound of formula or a pharmaceutically acceptable salt thereof, wherein: A is a 6-membered heteroaryl group selected from pyridinyl, pyradizinyl, pyrazinyl and pyrimidinyl; R 1 is halogen, C 1 -C 6 -alkyl or C 2 -C 8 -alkoxyalkyl; R 3 and R 4 are each independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 - alkoxy, C 1 -C 6 -haloalkoxy, cyano, C 3 -C 12 -cycloalkyl, C 2 -C 9 -heterocycloalkyl, -NR 5 R 6 and -S 2 -R 7; R 5 and R 6 are each independently selected from hydrogen and C 1 -C 6 -alkyl, and R 7 is C 1 -C 6 -alkyl; X is N; n is 3; and m is 0. A is a 6-membered heteroaryl group selected from pyridinyl, pyradizinyl, pyrazinyl and pyrimidinyl; R 1 is halogen, C 1 -C 6 -alkyl or C 2 -C 8 -alkoxyalkyl; R 3 and R 4 are each independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 - alkoxy, C 1 -C 6 -haloalkoxy, cyano, C 3 -C 12 -cycloalkyl, C 2 -C 9 -heterocycloalkyl, -NR 5 R 6 and -S 2 -R 7; R 5 and R 6 are each independently selected from hydrogen and C 1 -C 6 -alkyl, and R 7 is C 1 -C 6 -alkyl; X is N; n is 3; and m is 0.
A copper alloy having a composition represented by the composition formula by atom%: Cu 100-a-b-c (Zr, Hf) a (Cr, Ni, Mn, Ta) b (Ti, Al) c [wherein, 2.5 ≤ a ≤ 4.0, 0.1 < b ≤ 1.5 and 0 ≤ c ≤ 0.2; (Zr, Hf) means one or both of Zr and Hf; (Cr, Ni, Mn, Ta) means one or more of Cr, Ni, Mn and Ta; and (Ti, Al) means one or both of Ti and Al], and having Cu primary phases in which the mean secondary dendrite arm spacing is 2 μm or less and eutectic matrices in which the lamellar spacing between a metastable Cu 5 (Zr, Hf) compound phase and a Cu phase is 0.2 μm or less.
A floating dispenser having a central axis comprising: a first dispensing cartridge having a base, a float, a dispersant chamber, and a set of fluid openings therein for ingress and egress of water into contact with a dispersant in the dispersant chamber; and a second dispensing cartridge containing a consumable dispersant therein having a specific gravity greater than one, said second dispensing cartridge having a base rotationally securable to the base of the first dispensing cartridge to control water access to the consumable dispersant therein by increasing or decreasing a flow area through alignment of internal ports in a grid in the first dispenser cartridge and a grid in the second dispenser cartridge without separating the two dispensing cartridges (11, 16) since there is only one position where the dispensing cartridges can be separated from each other, with the second dispensing cartridge and the first dispensing cartridge floating as a unit, with the first dispensing cartridge located above the second dispensing cartridge which is less buoyant than the first dispensing cartridge when the consumable dispersant is in an unconsumed state and floating below the second dispensing cartridge when the floating dispenser has self inverted 180 degrees in response to consumption of the consumable dispersant to thereby provide a visual indication that the consumable dispersant has been consumed. a first dispensing cartridge having a base, a float, a dispersant chamber, and a set of fluid openings therein for ingress and egress of water into contact with a dispersant in the dispersant chamber; and a second dispensing cartridge containing a consumable dispersant therein having a specific gravity greater than one, said second dispensing cartridge having a base rotationally securable to the base of the first dispensing cartridge to control water access to the consumable dispersant therein by increasing or decreasing a flow area through alignment of internal ports in a grid in the first dispenser cartridge and a grid in the second dispenser cartridge without separating the two dispensing cartridges (11, 16) since there is only one position where the dispensing cartridges can be separated from each other, with the second dispensing cartridge and the first dispensing cartridge floating as a unit, with the first dispensing cartridge located above the second dispensing cartridge which is less buoyant than the first dispensing cartridge when the consumable dispersant is in an unconsumed state and floating below the second dispensing cartridge when the floating dispenser has self inverted 180 degrees in response to consumption of the consumable dispersant to thereby provide a visual indication that the consumable dispersant has been consumed.