mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a P-gp inducer, for use in preventing one or more side effects of a chemotherapeutic and/or reducing the risk of getting one or more side effects of a chemotherapeutic and/or reducing the severity of one or more side effects of a chemotherapeutic and/or increasing the tolerability of a chemotherapeutic and/or removing dose limiting side effects of a chemotherapeutic in a subject, wherein, said chemotherapeutic, in vivo, is transported out of cells by P-gp; wherein the P-gp inducer is selected from the group consisting of rifampicin, carbamazepine and dexamethasone, wherein the chemotherapeutic is selected from the group consisting of taxanes, vinca alkaloids, epothilones, anthracyclines, proteasome inhibitors and topoisomerase inhibitors; wherein the P-gp inducer is prepared to be topically administered to the subject before administering the chemotherapeutic to the subject; and wherein said one or more side effects is selected from the group consisting of CIPN (i.e. chemotherapy-induced peripheral neuropathy), hair loss (alopecia), and nail damage, such as damage to the root of nails. wherein, said chemotherapeutic, in vivo, is transported out of cells by P-gp; wherein the P-gp inducer is selected from the group consisting of rifampicin, carbamazepine and dexamethasone, wherein the chemotherapeutic is selected from the group consisting of taxanes, vinca alkaloids, epothilones, anthracyclines, proteasome inhibitors and topoisomerase inhibitors; wherein the P-gp inducer is prepared to be topically administered to the subject before administering the chemotherapeutic to the subject; and wherein said one or more side effects is selected from the group consisting of CIPN (i.e. chemotherapy-induced peripheral neuropathy), hair loss (alopecia), and nail damage, such as damage to the root of nails.
A computer assisted orthopaedic system comprising: a display, a sensor module configured to transmit joint force data indicative of the joint force of a patient's knee joint, the module comprising (i) a tibial paddle configured to be inserted between a patient's tibia and femur, and (ii) a handle which extends from a side of the paddle so that the paddle can be positioned in a patient's knee joint without the need to sublux or to evert the patient's patella, a computer coupled to the display and including a receiver circuit configured to receive the joint force data from the sensor module the computer being configured: to determine position data indicative of a position of a patient's femur and a patient's tibia, to display an image of the patient's femur and the patient's tibia based on the position data, to determine a medial force value indicative of a medial component of the joint force based on the joint force data, to determine a lateral force value indicative of a lateral component of the joint force based on the joint force data, and to display the medial force value and the lateral force value on the display. a display, a sensor module configured to transmit joint force data indicative of the joint force of a patient's knee joint, the module comprising (i) a tibial paddle configured to be inserted between a patient's tibia and femur, and (ii) a handle which extends from a side of the paddle so that the paddle can be positioned in a patient's knee joint without the need to sublux or to evert the patient's patella, a computer coupled to the display and including a receiver circuit configured to receive the joint force data from the sensor module the computer being configured: to determine position data indicative of a position of a patient's femur and a patient's tibia, to display an image of the patient's femur and the patient's tibia based on the position data, to determine a medial force value indicative of a medial component of the joint force based on the joint force data, to determine a lateral force value indicative of a lateral component of the joint force based on the joint force data, and to display the medial force value and the lateral force value on the display. to determine position data indicative of a position of a patient's femur and a patient's tibia, to display an image of the patient's femur and the patient's tibia based on the position data, to determine a medial force value indicative of a medial component of the joint force based on the joint force data, to determine a lateral force value indicative of a lateral component of the joint force based on the joint force data, and to display the medial force value and the lateral force value on the display.
An aspiration syringe comprising: a barrel with a tip for attaching a needle; a piston having a stem and slidably mounted inside the barrel; and a grip located at an end of the stem, characterized in that the syringe is provided with a handle moveably attached to the stem grip and rotatable in relation to a hinge unit located at the stem grip, wherein the handle is formed at least as a bracket with a reverse grip located at an end opposite to the handle attachment and with a slot arranged in the middle portion and intended for enclosing the stem from two sides, and the bracket has an arched shape, wherein the radius of curvature of the bracket approximately equals the distance the piston exits the barrel in operation. characterized in that the syringe is provided with a handle moveably attached to the stem grip and rotatable in relation to a hinge unit located at the stem grip, wherein the handle is formed at least as a bracket with a reverse grip located at an end opposite to the handle attachment and with a slot arranged in the middle portion and intended for enclosing the stem from two sides, and the bracket has an arched shape, wherein the radius of curvature of the bracket approximately equals the distance the piston exits the barrel in operation.
A thermosetting resin composition comprising: a thermosetting resin and an adsorbing filler in which a thermoplastic resin C is adsorbed on a filler; wherein the filler is at least one selected from the group consisting of carbon black and silica, and an adsorption coefficient that is greater than 0 and less than or equal to 0.8, defined by Formula 1 below, is satisfied: Adsorption coefficient = Amount parts by mass of the thermoplastic resin C adsorbed on 100 parts by mass of the filler / specific gravity of the thermoplastic resin C / DBP oil absorption mL / 100 g of the filler. a thermosetting resin and an adsorbing filler in which a thermoplastic resin C is adsorbed on a filler; wherein the filler is at least one selected from the group consisting of carbon black and silica, and an adsorption coefficient that is greater than 0 and less than or equal to 0.8, defined by Formula 1 below, is satisfied: Adsorption coefficient = Amount parts by mass of the thermoplastic resin C adsorbed on 100 parts by mass of the filler / specific gravity of the thermoplastic resin C / DBP oil absorption mL / 100 g of the filler.
A dispensing apparatus for a flowable component comprising - a storage container having a first storage chamber for a first component and having a first component outlet and - a dispensing element which is connected to the storage container and which has a dispensing opening, wherein - the storage container has an outlet flange which encompasses the first component outlet (17, 19) and has a cylindrical jacket surface which is at least partly surrounded by an inlet flange of the dispensing element, - the inlet flange is arranged rotatable with respect to the outlet flange and - the inlet flange can adopt a closed position with respect to the outlet flange in which the first component outlet is closed and can adopt a dispensing position in which a dispensing of the first component is possible via the first component outlet (17, 19) and the dispensing opening and a change from the closed position into the dispensing position can be carried out by a rotation of the inlet flange with respect to the outlet flange, characterized in that - the first component outlet is arranged at the named jacket surface of the outlet flange, - the first component outlet (17, 19) is closed by the inlet flange in the closed position of the inlet flange, and - the inlet flange has a first crossover passage which is designed and arranged such that it establishes a connection between the first component outlet and the dispensing opening in the dispensing position of the inlet flange. - a storage container having a first storage chamber for a first component and having a first component outlet and - a dispensing element which is connected to the storage container and which has a dispensing opening, - the storage container has an outlet flange which encompasses the first component outlet (17, 19) and has a cylindrical jacket surface which is at least partly surrounded by an inlet flange of the dispensing element, - the inlet flange is arranged rotatable with respect to the outlet flange and - the inlet flange can adopt a closed position with respect to the outlet flange in which the first component outlet is closed and can adopt a dispensing position in which a dispensing of the first component is possible via the first component outlet (17, 19) and the dispensing opening and a change from the closed position into the dispensing position can be carried out by a rotation of the inlet flange with respect to the outlet flange, - the first component outlet is arranged at the named jacket surface of the outlet flange, - the first component outlet (17, 19) is closed by the inlet flange in the closed position of the inlet flange, and - the inlet flange has a first crossover passage which is designed and arranged such that it establishes a connection between the first component outlet and the dispensing opening in the dispensing position of the inlet flange.
A compound of formula I or a pharmaceutically acceptable salt thereof: wherein R 1, R 2 and R 3 are respectively and independently selected from the following substituents: H, C 1-6 alkyl, C 1-6 alkoxy, halogen, cyano, C 1-6 alkyl substituted by halogen or cyano.
Microparticles of chitosan hydrogel of a median size d50, obtained from a number distribution, comprised between 1 and 500 μm, the chitosan having a degree of acetylation of less than or equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on the total weight of the hydrogel, for their use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons or precursors of neural cells and/or in the treatment of neurodegenerative diseases and/or in the treatment of ischemic wounds and/or in the treatment of paralyses.
An optoelectronic safety barrier for detecting the intrusion of persons through a passage defined by two opposite sides, comprising: - an active column located on a first one of said sides of the passage, the active column bearing a first and a second cameras (14,16) having parallel optical axes directed across the passage towards the opposite side; - a passive column located on the opposite side of the passage and bearing two identical geometrical patterns (18, 20) which are respectively aligned with the optical axes of said first and second cameras and at equal distances from the respective cameras, the field of view of each of said cameras (14, 16) on the active column being such that it encompasses both said patterns; - a control system adapted to cyclically execute the following steps: - acquiring a first current image from said first camera and a second current image from said second camera, - flipping the second current image about a line (X-X) at right angles to the active column to obtain a flipped second current image, - overlapping and comparing said first current image and said flipped second current image, respectively, with a desired stored reference image, and - issuing an alarm signal whenever a difference is found between the reference image and either one of said first current image and said flipped second current image. - an active column located on a first one of said sides of the passage, the active column bearing a first and a second cameras (14,16) having parallel optical axes directed across the passage towards the opposite side; - a passive column located on the opposite side of the passage and bearing two identical geometrical patterns (18, 20) which are respectively aligned with the optical axes of said first and second cameras and at equal distances from the respective cameras, the field of view of each of said cameras (14, 16) on the active column being such that it encompasses both said patterns; - a control system adapted to cyclically execute the following steps: - acquiring a first current image from said first camera and a second current image from said second camera, - flipping the second current image about a line (X-X) at right angles to the active column to obtain a flipped second current image, - overlapping and comparing said first current image and said flipped second current image, respectively, with a desired stored reference image, and - issuing an alarm signal whenever a difference is found between the reference image and either one of said first current image and said flipped second current image. - acquiring a first current image from said first camera and a second current image from said second camera, - flipping the second current image about a line (X-X) at right angles to the active column to obtain a flipped second current image, - overlapping and comparing said first current image and said flipped second current image, respectively, with a desired stored reference image, and - issuing an alarm signal whenever a difference is found between the reference image and either one of said first current image and said flipped second current image.
A method for producing composites comprising aluminum oxide and cerium/zirconium (optionally rare earth) mixed oxides comprising the following steps: (a) providing a suspension comprising boehmite as the alumina precursor and adjusting the pH to 8 to 11.5; (b) producing an aqueous metal salt solution comprising metal salts of cerium and of zirconium; (c) bringing in contact the suspension of (a) with the metal salt solution from (b) at temperatures of 5 to 95°C or exposing the resulting slurry to these temperatures, wherein the suspension from (c) is hydrothermally aged in an aqueous environment at a temperature of at least 90°C and for at least one hour; (d) isolating the solids from (c) and (e) calcining the solids from (d). (a) providing a suspension comprising boehmite as the alumina precursor and adjusting the pH to 8 to 11.5; (b) producing an aqueous metal salt solution comprising metal salts of cerium and of zirconium; (c) bringing in contact the suspension of (a) with the metal salt solution from (b) at temperatures of 5 to 95°C or exposing the resulting slurry to these temperatures, wherein the suspension from (c) is hydrothermally aged in an aqueous environment at a temperature of at least 90°C and for at least one hour; (d) isolating the solids from (c) and (e) calcining the solids from (d).
A knob for a shifter assembly of a vehicle, said knob comprising: a housing having an interior surface defining a cavity and an opening extending into said cavity; a body at least partially disposed within said cavity having a first surface and a second surface spaced from one another with said body extending to a periphery and being formed of an at least partially transparent material; an illumination device disposed within said cavity between said interior surface of said housing and said body for emitting light rays; characterized by at least one reflective surface disposed along said periphery of said body for receiving the light rays from said illumination device with a first portion of the light rays reflecting off of said reflective surface and internally reflecting within said body off of said first surface toward said second surface; and at least one indicium disposed along said body; said body defining at least one indicium cavity having a bottom substantially parallel to said first surface with said indicium disposed within said indicium cavity along said bottom for reflecting the first portion of the light rays toward said opening for illuminating said indicium; said at least one reflective surface being further defined as a plurality of reflective surfaces disposed and staggered about said periphery of said body. a housing having an interior surface defining a cavity and an opening extending into said cavity; a body at least partially disposed within said cavity having a first surface and a second surface spaced from one another with said body extending to a periphery and being formed of an at least partially transparent material; an illumination device disposed within said cavity between said interior surface of said housing and said body for emitting light rays; characterized by at least one reflective surface disposed along said periphery of said body for receiving the light rays from said illumination device with a first portion of the light rays reflecting off of said reflective surface and internally reflecting within said body off of said first surface toward said second surface; and at least one indicium disposed along said body; said body defining at least one indicium cavity having a bottom substantially parallel to said first surface with said indicium disposed within said indicium cavity along said bottom for reflecting the first portion of the light rays toward said opening for illuminating said indicium; said at least one reflective surface being further defined as a plurality of reflective surfaces disposed and staggered about said periphery of said body.
A nanopore cell, comprising: a substrate; a conductive layer disposed overlying a top portion of the substrate; a first dielectric layer overlying the conductive layer, the first dielectric laye having an opening exposing a portion of the conductive layer, an electrode layer disposed in the opening of the first dielectric layer, the electrode layer having an overhang portion extending over the first dielectric layer, a second dielectric layer disposed on the first dielectric layer, a cavity in the second dielectric layer, the cavity exposing at least a portion of the electrode layer, the cavity including an undercut portion of the second dielectric layer above the overhang portion of the electrode, and a well formed by the cavity, the well having a bottom base formed by a top surface of the electrode layer and well sidewalls formed by the second dielectric layer. a substrate; a conductive layer disposed overlying a top portion of the substrate; a first dielectric layer overlying the conductive layer, the first dielectric laye having an opening exposing a portion of the conductive layer, an electrode layer disposed in the opening of the first dielectric layer, the electrode layer having an overhang portion extending over the first dielectric layer, a second dielectric layer disposed on the first dielectric layer, a cavity in the second dielectric layer, the cavity exposing at least a portion of the electrode layer, the cavity including an undercut portion of the second dielectric layer above the overhang portion of the electrode, and a well formed by the cavity, the well having a bottom base formed by a top surface of the electrode layer and well sidewalls formed by the second dielectric layer.
A method for wireless communication, comprising: transmitting, at a base station, a channel state information reference signal, CSI-RS, in a downlink, DL, common burst of an uplink, UL, centric subframe; receiving UL data in a UL data burst of the UL centric subframe; and receiving, from a mobile station, channel state feedback, CSF, information in the UL data burst or a UL common burst of the UL centric subframe in response to the CSI-RS, wherein the CSF is generated at the mobile station based on the CSI-RS, wherein the DL common burst includes a control region including one or more of the following: a UL grant for transmitting the UL data in the UL data burst, resources in the UL data burst for transmitting the UL data. transmitting, at a base station, a channel state information reference signal, CSI-RS, in a downlink, DL, common burst of an uplink, UL, centric subframe; receiving UL data in a UL data burst of the UL centric subframe; and receiving, from a mobile station, channel state feedback, CSF, information in the UL data burst or a UL common burst of the UL centric subframe in response to the CSI-RS, wherein the CSF is generated at the mobile station based on the CSI-RS, wherein the DL common burst includes a control region including one or more of the following: a UL grant for transmitting the UL data in the UL data burst, resources in the UL data burst for transmitting the UL data.
Drive arrangement for the motorized adjustment of a flap arrangement for a motor vehicle, with a drive controller for realizing a respectively predefined desired flap adjustment by means of at least one drive (2, 3), wherein the flap arrangement is configured with two wings, wherein the two flap wings (4, 5) are substantially pivotable about two spaced-apart, parallel pivot axes (6, 7) and, in the closed state, are in engagement with each other via the free wing ends (4a, 5a) thereof opposite the respective pivot axis (6, 7), wherein the two flap wings (4, 5) are assigned collusion pivoting regions (8, 9) which are mounted upstream of the respective closed position and in which the movement regions (10, 11) of the flap wings (4, 5) overlap in such a manner that a predetermined opening and closing sequence has to be observed there in order to avoid collisions between the free wing ends (4a, 5a), characterized in that the two collision pivoting regions are stored in the drive controller and in that, in the event that a desired flap adjustment runs counter to the predetermined opening and closing sequence in the collision pivoting regions (8, 9) of the flap wings (4, 5), the drive controller temporarily pivots one of the flap wings (4, 5) out of the initial position thereof in a deviating movement into a parking position located outside the collision pivoting region (8, 9) of said flap wing in order to avoid a collision.
Luminous motor-vehicle device, said device comprising: - a segmenting part including a plurality of through-cavities; - a plurality of light sources upstream of the segmenting part; - a mask that blocks at least one through-cavity of the segmenting part, said mask being able to be partially passed through by light and including at least one apertured zone; and the mask and the segmenting part being arranged with respect to each other so that the apertured zone is placed facing at least one through-cavity said luminous device being arranged so that each through-cavity directly or indirectly receives light from at least one separate light source. - a segmenting part including a plurality of through-cavities; - a plurality of light sources upstream of the segmenting part; - a mask that blocks at least one through-cavity of the segmenting part, said mask being able to be partially passed through by light and including at least one apertured zone; and the mask and the segmenting part being arranged with respect to each other so that the apertured zone is placed facing at least one through-cavity said luminous device being arranged so that each through-cavity directly or indirectly receives light from at least one separate light source. the mask and the segmenting part being arranged with respect to each other so that the apertured zone is placed facing at least one through-cavity said luminous device being arranged so that each through-cavity directly or indirectly receives light from at least one separate light source.