A method of synthesizing 2,3,3,3-tetrafluoropropene comprising: (a) contacting 1,3,3,3-tetrachloropropane with a base at a temperature sufficient to effect dehydrochlorination to form 1,1,3-trichloro-1-propene; (b) contacting the 1,1,3-trichloro-1-propene, in the vapor phase, with hydrogen fluoride in the presence of a fluorination catalyst at a temperature sufficient to effect formation of 3,3,3-trifluoropropene; and contacting the 3,3,3-trifluoropropene with one or more additional reagents sufficient to effect formation of 2,3,3,3-tetrafluoropropene, wherein the step of contacting the 3,3,3-trifluoropropene with one or more additional reagents includes the steps of: (c) contacting the 3,3,3-trifluoropropene in the vapor phase with chlorine gas at a temperature to effect formation of 2,3-dichloro-1,1,1-trifluoropropane; (d) contacting the 2,3-dichloro-1,1,1-trifluoropropane in the vapor phase in the presence of a dehydrochlorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2-chloro-3,3,3-trifluoropropene; (e) contacting the 2-chloro-3,3,3-trifluoropropene in the vapor phase or in the liquid phase, with hydrogen fluoride in the presence of a fluorination catalyst at a temperature sufficient to effect formation of 2-chloro-2,3,3,3-tetrafluoropropane; and (f) contacting the 2-chloro-2,3,3,3-tetrafluoropropane in the vapor phase in the presence or absence of a dehydrofluorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2,3,3,3-tetrafluoropropene. (a) contacting 1,3,3,3-tetrachloropropane with a base at a temperature sufficient to effect dehydrochlorination to form 1,1,3-trichloro-1-propene; (b) contacting the 1,1,3-trichloro-1-propene, in the vapor phase, with hydrogen fluoride in the presence of a fluorination catalyst at a temperature sufficient to effect formation of 3,3,3-trifluoropropene; and contacting the 3,3,3-trifluoropropene with one or more additional reagents sufficient to effect formation of 2,3,3,3-tetrafluoropropene, wherein the step of contacting the 3,3,3-trifluoropropene with one or more additional reagents includes the steps of: (c) contacting the 3,3,3-trifluoropropene in the vapor phase with chlorine gas at a temperature to effect formation of 2,3-dichloro-1,1,1-trifluoropropane; (d) contacting the 2,3-dichloro-1,1,1-trifluoropropane in the vapor phase in the presence of a dehydrochlorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2-chloro-3,3,3-trifluoropropene; (e) contacting the 2-chloro-3,3,3-trifluoropropene in the vapor phase or in the liquid phase, with hydrogen fluoride in the presence of a fluorination catalyst at a temperature sufficient to effect formation of 2-chloro-2,3,3,3-tetrafluoropropane; and (f) contacting the 2-chloro-2,3,3,3-tetrafluoropropane in the vapor phase in the presence or absence of a dehydrofluorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2,3,3,3-tetrafluoropropene. (c) contacting the 3,3,3-trifluoropropene in the vapor phase with chlorine gas at a temperature to effect formation of 2,3-dichloro-1,1,1-trifluoropropane; (d) contacting the 2,3-dichloro-1,1,1-trifluoropropane in the vapor phase in the presence of a dehydrochlorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2-chloro-3,3,3-trifluoropropene; (e) contacting the 2-chloro-3,3,3-trifluoropropene in the vapor phase or in the liquid phase, with hydrogen fluoride in the presence of a fluorination catalyst at a temperature sufficient to effect formation of 2-chloro-2,3,3,3-tetrafluoropropane; and (f) contacting the 2-chloro-2,3,3,3-tetrafluoropropane in the vapor phase in the presence or absence of a dehydrofluorination catalyst or in the liquid phase with a base at a temperature sufficient to effect dehydrochlorination to form 2,3,3,3-tetrafluoropropene.