mhurhangee/ep-ind-claims huggingface dataset:
A compound according to formula 1, wherein the compound exhibits cytotoxic activity and: R 2 is hydrogen or dimethylamino; R 3 is hydrogen; R 4 is cycloalkyl optionally substituted with alkyl, or benzyl optionally substituted with halogen; or R 3 and R 4, together with the nitrogen atom to which they are attached, form piperidinyl substituted with one or more substituents independently selected from the group consisting of: hydroxyl and phenyl optionally substituted with halogen; R 5 is alkyl or benzyl optionally substituted with halogen; and R 6 is benzodioxolyl or phenyl optionally substituted with one to three substituents independently selected from the group consisting of: halogen, hydroxyl, alkoxy optionally substituted with halogen, alkyl, phenoxy optionally substituted with halogen, cyano, or alkyl, and phenyl optionally substituted with alkyl or halogen; or a pharmaceutically-acceptable salt thereof. R 2 is hydrogen or dimethylamino; R 3 is hydrogen; R 4 is cycloalkyl optionally substituted with alkyl, or benzyl optionally substituted with halogen; or R 3 and R 4, together with the nitrogen atom to which they are attached, form piperidinyl substituted with one or more substituents independently selected from the group consisting of: hydroxyl and phenyl optionally substituted with halogen; R 5 is alkyl or benzyl optionally substituted with halogen; and R 6 is benzodioxolyl or phenyl optionally substituted with one to three substituents independently selected from the group consisting of: halogen, hydroxyl, alkoxy optionally substituted with halogen, alkyl, phenoxy optionally substituted with halogen, cyano, or alkyl, and phenyl optionally substituted with alkyl or halogen; or a pharmaceutically-acceptable salt thereof. hydroxyl and phenyl optionally substituted with halogen; R 5 is alkyl or benzyl optionally substituted with halogen; and R 6 is benzodioxolyl or phenyl optionally substituted with one to three substituents independently selected from the group consisting of: halogen, hydroxyl, alkoxy optionally substituted with halogen, alkyl, phenoxy optionally substituted with halogen, cyano, or alkyl, and phenyl optionally substituted with alkyl or halogen; or a pharmaceutically-acceptable salt thereof.
A system for separating a multicomponent fluid into two or more flow channels (161, 162), each containing components with different buoyancy, comprising: a housing having a fluid inlet at a first end and at least two outlets (165, 169), the housing having an inner cylindrical surface with an approximately constant cross section; a first member configured to fit within the housing at the first end of the housing and having a passageway from the fluid inlet through the first member, the first member having a conical concave inner surface; a second member having a conical convex surface at one end that fits into the concave inner surface of the first member, the second member having at least one helical channel (144, 144') on an outer cylindrical surface extending from the convex surface to an opposite end of the second member, and wherein a gap formed between the concave and the convex surfaces of the first and second members has a funnel shape with the fluid inlet at a first end along the central axis and the outlets at a second end in an annulus shape, wherein in operation, the concave and convex surfaces direct the fluid flow into the helical channels (144, 144') formed in the second member; and a third member having a central fluid passageway for carrying higher buoyancy fluid and extending through the third member along a central axis, and at least one other fluid passageway for carrying lower buoyancy fluid with an inlet positioned radially outward of an inlet of the central fluid passageway; wherein the first member, the second member, and the third member are configured to fit within the housing and aligned along a central longitudinal axis. a housing having a fluid inlet at a first end and at least two outlets (165, 169), the housing having an inner cylindrical surface with an approximately constant cross section; a first member configured to fit within the housing at the first end of the housing and having a passageway from the fluid inlet through the first member, the first member having a conical concave inner surface; a second member having a conical convex surface at one end that fits into the concave inner surface of the first member, the second member having at least one helical channel (144, 144') on an outer cylindrical surface extending from the convex surface to an opposite end of the second member, and wherein a gap formed between the concave and the convex surfaces of the first and second members has a funnel shape with the fluid inlet at a first end along the central axis and the outlets at a second end in an annulus shape, wherein in operation, the concave and convex surfaces direct the fluid flow into the helical channels (144, 144') formed in the second member; and a third member having a central fluid passageway for carrying higher buoyancy fluid and extending through the third member along a central axis, and at least one other fluid passageway for carrying lower buoyancy fluid with an inlet positioned radially outward of an inlet of the central fluid passageway; wherein the first member, the second member, and the third member are configured to fit within the housing and aligned along a central longitudinal axis.
A die pack mounting for a bodymaker, said die pack mounting comprising: a die pack mounting bed; a die pack mounting door assembly, said die pack mounting door assembly movably coupled to said die pack mounting bed; and said die pack mounting door assembly movable between an open, first position, wherein said die pack mounting door assembly is structured to support a die pack in a maintenance configuration, and, a closed, second position, wherein said die pack mounting door assembly fixes said die pack in a selected position, wherein said die pack mounting door assembly includes a body having an inner side, an outer side, a forward side and a rear side, and characterized by: said die pack mounting door assembly body defining a number coolant passages; said die pack mounting door assembly body coolant passages including a number of inlets, outlets and machining portals; each said coolant passage outlet disposed on said die pack mounting door assembly body inner side; a number of plugs; and wherein each plug is disposed in an associated coolant passage machining portal. a die pack mounting bed; a die pack mounting door assembly, said die pack mounting door assembly movably coupled to said die pack mounting bed; and said die pack mounting door assembly movable between an open, first position, wherein said die pack mounting door assembly is structured to support a die pack in a maintenance configuration, and, a closed, second position, wherein said die pack mounting door assembly fixes said die pack in a selected position, wherein said die pack mounting door assembly includes a body having an inner side, an outer side, a forward side and a rear side, and characterized by: said die pack mounting door assembly body defining a number coolant passages; said die pack mounting door assembly body coolant passages including a number of inlets, outlets and machining portals; each said coolant passage outlet disposed on said die pack mounting door assembly body inner side; a number of plugs; and wherein each plug is disposed in an associated coolant passage machining portal. said die pack mounting door assembly body defining a number coolant passages; said die pack mounting door assembly body coolant passages including a number of inlets, outlets and machining portals; each said coolant passage outlet disposed on said die pack mounting door assembly body inner side; a number of plugs; and wherein each plug is disposed in an associated coolant passage machining portal.
A composition comprising an adeno-associated virus viral vector which has a clade F AAV capsid which comprises a cell surface β-galactose binding domain for use in therapy in combination with a neuraminidase which provides means for enzymatic cleavage of sialic acid in a subject having cells with a cell surface glycan having terminal sialic acid and a penultimate β-galactose, wherein said AAV vector further comprises a minigene having AAV inverted terminal repeats and a heterologous gene operably linked to regulatory sequences which direct its expression in a host cell.
A method for enhancing the activity of a protease in a washing or cleaning agent, characterized in that a microbial metabolite is added to the washing or cleaning agent which, in conjunction with the protease, provides synergistic cleaning performance when the agent is used, the microbial metabolite being selected from the group consisting of 2,3-butanediol, pyruvate, propionate, butyrate, and levane.
A composition comprising a non-toxic sodium chloride-free aqueous gel containing at least 20% by weight of a cosmetically-acceptable oil being any or a mixture of isopropyl myristate, isopropyl palmitate and isononyl isononanoate, a thickener and at least 60% by weight water, wherein the cosmetically-acceptable oil is isononyl isononanoate, for use in the treatment of a human or an animal to loosen louse ova and nits.
An apparatus suitable for landing in a wellhead, comprising: a helix structure comprising: at least one helical surface; a spring-loaded, outwardly-biased orientation key; a plurality of orientation slots positioned around a perimeter of the helix structure, each of the orientation slots being adapted to receive the spring-loaded, outwardly-biased orientation key; a component orientation slot positioned adjacent a bottom end of the at least one helical surface; and characterized by a threaded bottom recess; and a threaded adjustable nut that is adapted to be at least partially positioned in the bottom recess and threadingly coupled to the threaded bottom recess, the threaded adjustable nut further comprising a bottom landing surface. a helix structure comprising: at least one helical surface; a spring-loaded, outwardly-biased orientation key; a plurality of orientation slots positioned around a perimeter of the helix structure, each of the orientation slots being adapted to receive the spring-loaded, outwardly-biased orientation key; a component orientation slot positioned adjacent a bottom end of the at least one helical surface; and characterized by a threaded bottom recess; and at least one helical surface; a spring-loaded, outwardly-biased orientation key; a plurality of orientation slots positioned around a perimeter of the helix structure, each of the orientation slots being adapted to receive the spring-loaded, outwardly-biased orientation key; a component orientation slot positioned adjacent a bottom end of the at least one helical surface; and characterized by a threaded bottom recess; and a threaded adjustable nut that is adapted to be at least partially positioned in the bottom recess and threadingly coupled to the threaded bottom recess, the threaded adjustable nut further comprising a bottom landing surface.
A spark plug for an internal combustion engine, the spark plug comprising: an elongated center electrode having a center electrode tip at one end and a terminal proximate to another end; an insulator surrounding a portion of the center electrode, the insulator having a channel formed in an exterior surface of the insulator; and a jamb nut surrounding the insulator, the jamb nut being aligned with the channel such that a distal end of the jamb nut does not contact the insulator wherein the backside of the jam nut portion does not make contact with the barrel surface of the insulator but characterised in that: there is securement of a outer shell to the insulator. an elongated center electrode having a center electrode tip at one end and a terminal proximate to another end; an insulator surrounding a portion of the center electrode, the insulator having a channel formed in an exterior surface of the insulator; and a jamb nut surrounding the insulator, the jamb nut being aligned with the channel such that a distal end of the jamb nut does not contact the insulator wherein the backside of the jam nut portion does not make contact with the barrel surface of the insulator but characterised in that: there is securement of a outer shell to the insulator.
A C797S resistant mutant EGFR specific tyrosine kinase inhibitor comprising a compound represented by the formula: wherein X is O or NH, R 1 and R 2 are each independently a hydrogen atom or an optionally substituted hydrocarbon group, wherein at least one of R 1 and R 2 is a C 1-6 alkyl group substituted by an amino group disubstituted by a methyl group; R 3 and R 4 are each independently a hydrogen atom, a halogen atom or an optionally substituted hydrocarbon group, and R 5 and R 6 are each independently an optionally substituted hydrocarbon group, or a salt thereof, for use as a medicament. X is O or NH, R 1 and R 2 are each independently a hydrogen atom or an optionally substituted hydrocarbon group, wherein at least one of R 1 and R 2 is a C 1-6 alkyl group substituted by an amino group disubstituted by a methyl group; R 3 and R 4 are each independently a hydrogen atom, a halogen atom or an optionally substituted hydrocarbon group, and R 5 and R 6 are each independently an optionally substituted hydrocarbon group,
A spinning position device for a ring spinning machine comprising a spindle for a package body, which spindle is rotatably mounted on a spindle rail, and an encapsulation extending in the longitudinal direction of the spindle and enclosing the package body, wherein the encapsulation being connected to the spindle rail, is longitudinally divided and has a rear encapsulation wall and a front encapsulation wall, wherein the front encapsulation wall being movable into an open position, so that in the open position the package body of the spinning position device is accessible for operation, characterised in that the spinning position device further has a spindle brake which can be actuated by opening the encapsulation in order to brake the spindle or package body, wherein the brake force of the spindle brake can be controlled. a spindle for a package body, which spindle is rotatably mounted on a spindle rail, and an encapsulation extending in the longitudinal direction of the spindle and enclosing the package body, wherein the encapsulation being connected to the spindle rail, is longitudinally divided and has a rear encapsulation wall and a front encapsulation wall, wherein the front encapsulation wall being movable into an open position, so that in the open position the package body of the spinning position device is accessible for operation, characterised in that the spinning position device further has a spindle brake which can be actuated by opening the encapsulation in order to brake the spindle or package body, wherein the brake force of the spindle brake can be controlled.
An aircraft propulsion system comprising; a propulsor; a motor arranged to drive the propulsor; and a reduction gearbox coupled to a prime mover comprising the motor and / or a gas turbine engine at an input side, and the propulsor at an output side, the reduction gearbox being configured to provide a reduction ratio between the input and output; wherein the reduction gearbox is configured such that the input side rotates in an opposite direction to the output side, and the prime mover, motor, propulsor and reduction gearbox are configured such that gyroscopic forces of the propulsor, motor, prime mover and reduction gearbox generated during aircraft manoeuvres are substantially cancelled; characterised in that the motor, propulsor and reduction gearbox are configured such that, at a given input and output rotational speed, the total angular momentum of clockwise rotating components is within 20% of the sum of total angular momentum of anti-clockwise rotating components. a propulsor; a motor arranged to drive the propulsor; and a reduction gearbox coupled to a prime mover comprising the motor and / or a gas turbine engine at an input side, and the propulsor at an output side, the reduction gearbox being configured to provide a reduction ratio between the input and output; wherein the reduction gearbox is configured such that the input side rotates in an opposite direction to the output side, and the prime mover, motor, propulsor and reduction gearbox are configured such that gyroscopic forces of the propulsor, motor, prime mover and reduction gearbox generated during aircraft manoeuvres are substantially cancelled; characterised in that the motor, propulsor and reduction gearbox are configured such that, at a given input and output rotational speed, the total angular momentum of clockwise rotating components is within 20% of the sum of total angular momentum of anti-clockwise rotating components.
A method of making a semiconductor buried-heterostructure quantum cascade laser chip (Fig. 4; Fig. 5) configured for epitaxial-side-down bonding, said chip comprising a substrate (28; 34), an active region (26; 31) with two facets, a cladding (25; 32), a burying layer (27; 33), and a top electrode (24; 30) providing for current injection into said active region, characterized by - etching a trench (23; 29) extending, with the exception of the two facets of said active region (26; 31), in other words with the exception of the facets of the waveguide, around the circumference of said chip, - said trench having a cross-section with a width of about 5-15% of the width of said chip and a depth of about 2-10% of the thickness of said chip. - etching a trench (23; 29) extending, with the exception of the two facets of said active region (26; 31), in other words with the exception of the facets of the waveguide, around the circumference of said chip, - said trench having a cross-section with a width of about 5-15% of the width of said chip and a depth of about 2-10% of the thickness of said chip.
Structural assembly for a fluid-flow machine provided with: - a main flow path boundary confining a main flow path of a fluid-flow machine, where at least one row of blades each with one blade end is arranged in the main flow path, where a gap exists between the blade ends of the at least one row of blades and the main flow path boundary, and where there is a rotating relative movement between the blades of a blade row and the main flow path boundary, and - at least one secondary flow duct, having one opening (111, 112) each provided in the main flow path boundary at ends spaced apart in the flow direction, such that the secondary flow duct is connected to the main flow path via the two openings (111, 112), where the secondary flow duct is designed as a one-way duct, having a first opening (111, 112) through which fluid flows into the secondary flow duct and a second opening (112, 111) through which fluid exits the secondary flow duct, characterized in that the structural assembly has at least one support component and at least one insertion component, where in the support component a recess (210, 211) extending in the circumferential direction is provided that receives at least one insertion component such that the support component surrounds the at least one insertion component largely on its sides not facing the main flow path, and where the insertion component surrounds or forms at least one secondary flow duct so completely that all wetted surfaces of the secondary flow duct are associated with the insertion component in undivided manner. - a main flow path boundary confining a main flow path of a fluid-flow machine, where at least one row of blades each with one blade end is arranged in the main flow path, where a gap exists between the blade ends of the at least one row of blades and the main flow path boundary, and where there is a rotating relative movement between the blades of a blade row and the main flow path boundary, and - at least one secondary flow duct, having one opening (111, 112) each provided in the main flow path boundary at ends spaced apart in the flow direction, such that the secondary flow duct is connected to the main flow path via the two openings (111, 112), where the secondary flow duct is designed as a one-way duct, having a first opening (111, 112) through which fluid flows into the secondary flow duct and a second opening (112, 111) through which fluid exits the secondary flow duct,
An article being an article of apparel or an article of footwear, the article comprising a three-dimensional object (1210; 1305; 2002) printed onto a surface of the article by dispensing droplets of print material including one or more pigments, the surface of the article being a non-white substrate for the three-dimensional object (1210; 1305; 2002), wherein the non-white substrate is of a material being a textile, natural fabric, synthetic fabric, knit, woven material, nonwoven material, mesh, leather, synthetic leather, polymer, rubber, or foam, or any combination of them, the three-dimensional object comprising: a lower color graphic layer (620; 1320; 1804; 2004) printed onto the non-white substrate; one or more transparent structural layers (1104; 1322; 1806; 2006) printed onto the lower color graphic layer (620; 1320; 1804; 2004); and an upper color graphic layer (1208; 1324; 1808; 2010) printed onto an uppermost layer of the one or more transparent structural layers (620; 1320; 1804; 2004), wherein the upper color graphic layer (1208; 1324; 1808; 2010) and the lower color graphic layer (620; 1320; 1804; 2004) collectively visually depict a color graphic image, the article being characterized in that it further comprises: a white layer printed onto the non-white substrate of the article below the lower color graphic layer (620; 1320; 1804; 2004). a lower color graphic layer (620; 1320; 1804; 2004) printed onto the non-white substrate; one or more transparent structural layers (1104; 1322; 1806; 2006) printed onto the lower color graphic layer (620; 1320; 1804; 2004); and an upper color graphic layer (1208; 1324; 1808; 2010) printed onto an uppermost layer of the one or more transparent structural layers (620; 1320; 1804; 2004), wherein the upper color graphic layer (1208; 1324; 1808; 2010) and the lower color graphic layer (620; 1320; 1804; 2004) collectively visually depict a color graphic image, the article being characterized in that it further comprises: a white layer printed onto the non-white substrate of the article below the lower color graphic layer (620; 1320; 1804; 2004).
A method for a transmitter apparatus configured to transmit signals to a receiver apparatus using a beam selected from a plurality of available beams, wherein a set of the plurality of available beams is for beam selection measurements by the receiver apparatus, the method comprising: determining a collection of linear combinations of beams of the set, wherein the cardinality of the collection is lower than a cardinality of the set and larger than one, and wherein each of the linear combinations is a unique linear combination of all of the beams of the set, each beam of the set providing a non-zero contribution to each of the linear combinations; and transmitting each of the linear combinations of beams for beam selection measurements by the receiver apparatus. determining a collection of linear combinations of beams of the set, wherein the cardinality of the collection is lower than a cardinality of the set and larger than one, and wherein each of the linear combinations is a unique linear combination of all of the beams of the set, each beam of the set providing a non-zero contribution to each of the linear combinations; and transmitting each of the linear combinations of beams for beam selection measurements by the receiver apparatus.
A method of diagnosing and/or monitoring traumatic brain injury in a subject, wherein the TBI is severe TBI (sTBI), the method comprising determining a level of at least one miRNA in a fluid sample obtained from the subject, wherein the fluid sample comprises serum, and wherein the at least one miRNA comprises miR-335.