mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing a compound of the formula I: or a pharmaceutically acceptable salt thereof, which comprises: contacting a compound of the formula II: with an activating agent selected from oxalyl chloride, thionyl chloride, POCl 3, pivaloyl chloride, benzyl chloroformate, to form the acid chloride, followed by contacting the acid chloride with a compound of the formula III: or a salt thereof, in the presence of a weak base to give the compound of the formula I, or a pharmaceutically acceptable salt thereof; wherein the compound of the formula III or salt thereof, is prepared by: contacting a compound of the formula IV: with an asymmetric reducing agent in the presence of a weak base, and a terminal reductant to give the compound of the formula III, or a salt thereof. contacting a compound of the formula II: with an activating agent selected from oxalyl chloride, thionyl chloride, POCl 3, pivaloyl chloride, benzyl chloroformate, to form the acid chloride, followed by contacting the acid chloride with a compound of the formula III: or a salt thereof, in the presence of a weak base to give the compound of the formula I, or a pharmaceutically acceptable salt thereof; wherein the compound of the formula III or salt thereof, is prepared by: contacting a compound of the formula IV: with an asymmetric reducing agent in the presence of a weak base, and a terminal reductant to give the compound of the formula III, or a salt thereof. contacting a compound of the formula IV: with an asymmetric reducing agent in the presence of a weak base, and a terminal reductant to give the compound of the formula III, or a salt thereof.
A system for delivering an implant, the system comprising a delivery device comprising: an outer tubular member; an inner tubular member being within the outer tubular member, wherein the inner tubular member is adapted to house at least a portion of an implant; one or more structures slidably advanceable within a lumen of the inner tubular member to cause deployment of the implant from within the inner tubular member; and a proximal control device coupled with the inner tubular member and the one or more structures, and releasably coupled with the outer tubular member through a coupling mechanism, wherein the proximal control device comprises a pull wire and an actuator, the actuator comprising a rotatable wheel, an extension, a latch, and a ledge, wherein the pull wire extends through at least a portion of the outer tubular member, wherein the rotatable wheel is adapted to wind and unwind the pull wire and is located within a housing, wherein the extension has first and second sides and extends from the housing, and wherein the latch is housed within the extension and is slidable from the first side to the second side of the extension, and wherein the ledge is disposed on the housing and is adapted to frictionally engage the latch. an outer tubular member; an inner tubular member being within the outer tubular member, wherein the inner tubular member is adapted to house at least a portion of an implant; one or more structures slidably advanceable within a lumen of the inner tubular member to cause deployment of the implant from within the inner tubular member; and a proximal control device coupled with the inner tubular member and the one or more structures, and releasably coupled with the outer tubular member through a coupling mechanism, wherein the proximal control device comprises a pull wire and an actuator, the actuator comprising a rotatable wheel, an extension, a latch, and a ledge, wherein the pull wire extends through at least a portion of the outer tubular member, wherein the rotatable wheel is adapted to wind and unwind the pull wire and is located within a housing, wherein the extension has first and second sides and extends from the housing, and wherein the latch is housed within the extension and is slidable from the first side to the second side of the extension, and wherein the ledge is disposed on the housing and is adapted to frictionally engage the latch.
A cutting apparatus for providing a tissue graft, comprising: an annular cutting surface adapted to contract from a first diameter to a second diameter that is less than the first diameter, characterized in that the cutting apparatus is adapted for providing a tapered tissue graft.
A method for operating a CDMA mobile communication system, comprising: a) measuring a total receive power of uplink signals, at at least one base station, transmitted from one or more mobile stations located in a cell; b) measuring a sum of receive power of one or more EDCH, enhanced dedicated channel(s), in the cell; and c) calculating a total receive power of non-EDCH, non-enhanced dedicated channel, excluding the EDCH by subtracting said sum of the receive power from said measured total receive power. a) measuring a total receive power of uplink signals, at at least one base station, transmitted from one or more mobile stations located in a cell; b) measuring a sum of receive power of one or more EDCH, enhanced dedicated channel(s), in the cell; and c) calculating a total receive power of non-EDCH, non-enhanced dedicated channel, excluding the EDCH by subtracting said sum of the receive power from said measured total receive power.
A process for polymerizing an epoxide monomer, preferably ethylene oxide, comprising carrying out the process in the presence of a catalytically active amount of a catalyst obtainable by a preparation process comprising admixing at least one alkaline earth metal, liquid ammonia, an alkylene oxide, which is optionally substituted by aromatic radicals, and an organic nitrile having at least one acidic hydrogen atom to prepare a slurry of modified alkaline earth hexammine in liquid ammonia; continuously transferring the slurry of modified alkaline earth hexammine in liquid ammonia into a stripper vessel and continuously evaporating ammonia, thereby accumulating the modified catalyst in the stripper vessel; and upon complete transfer of the slurry of modified alkaline earth hexammine into the stripper vessel, aging the modified catalyst to obtain the final polymerization catalyst.
A multi-laser eye tracking system comprising: a plurality of laser light sources that includes at least a first laser light source and a second laser light source; scanning optics configured to scan light from the plurality of laser light sources across a region that includes an eye of a user, the scanning optics configured to scan first light from the first laser light source across a first portion of the region during a first period of time, the scanning optics configured to scan second light from the second laser light source across a second portion of the region during a second period of time that is different from the first period of time, the first portion of the region and the second portion of the region at least partially overlapping; a plurality of photodetectors configured to generate one or more respective analog signals, each photodetector configured to detect a portion of the light that is reflected from an iris of the eye and configured to generate the respective analog signal based at least in part on the detected portion of the light; an analog-to-digital converter configured to convert a sum of the one or more analog signals that are generated by the plurality of respective photodetectors to a digital signal; and one or more processors configured to: calculate a current mirror scan angle of a scanning mirror of the scanning optics; and provide the digital signal into a pixel of a frame buffer based at least in part on the current mirror scan angle. a plurality of laser light sources that includes at least a first laser light source and a second laser light source; scanning optics configured to scan light from the plurality of laser light sources across a region that includes an eye of a user, the scanning optics configured to scan first light from the first laser light source across a first portion of the region during a first period of time, the scanning optics configured to scan second light from the second laser light source across a second portion of the region during a second period of time that is different from the first period of time, the first portion of the region and the second portion of the region at least partially overlapping; a plurality of photodetectors configured to generate one or more respective analog signals, each photodetector configured to detect a portion of the light that is reflected from an iris of the eye and configured to generate the respective analog signal based at least in part on the detected portion of the light; an analog-to-digital converter configured to convert a sum of the one or more analog signals that are generated by the plurality of respective photodetectors to a digital signal; and one or more processors configured to: calculate a current mirror scan angle of a scanning mirror of the scanning optics; and provide the digital signal into a pixel of a frame buffer based at least in part on the current mirror scan angle. calculate a current mirror scan angle of a scanning mirror of the scanning optics; and provide the digital signal into a pixel of a frame buffer based at least in part on the current mirror scan angle.
A high molecular weight derivative of a nucleic acid antimetabolite, in which the nucleic acid antimetabolite is linked to the carboxyl group in the side chain of the high molecular weight compound comprising a polyethylene glycol moiety and a polymer moiety having a carboxyl group in the side chain via a hydrophobic linker represented by the following formula: wherein R represents a hydrogen atom or a C1-C6 alkyl group; A represents a hydrogen atom, a C1-C6 acyl group or a C1-C6 alkoxycarbonyl group; a+b represents from 3 to 200 as an average value, while a represents 75 to 100% of a+b, and b represents 0 to 25% of a+b; n represents from 5 to 2000 as an average value; X represents a hydrophobic amino acid residue or a hydrophobic amino acid derivative residue; Y represents two or more groups selected from the group consisting of a residue of a nucleic acid antimetabolite represented by the following formulae: a hydroxyl group, and -N CONH, wherein R1 and R2 may be identical or different, and are each a C1-C6 alkyl group which may be substituted with a tertiary amino group, and wherein, assuming that a+b is 100%, the number of nucleic acid antimetabolite residue is 5 to 80%, the number of - N CONH is 0 to 70%, and the number of hydroxyl group is 0 to 70%; and the constituent units of polyglutamic acid are bound in any order.
A method for manufacturing an inflatable bladder, comprising the steps of: (a) positioning (20(a)) a barrier material between a first film and a second film in a configuration that corresponds to the shape of an inflatable compartment of the inflatable bladder; (b) positioning (20(b)) said first and second films, with said barrier material positioned thereinbetween, between a first ply of material and a second ply of material, wherein at least one of said first and second plies of material is textured; (c) adhering (20(c)) said first film to said second film, except in the vicinity of said barrier material, to form said inflatable bladder having said inflatable compartment surrounded by a sealed, continuously substantially flat perimeter; and (d) removing (20(d)) said first and second plies of material from the inflatable bladder. (a) positioning (20(a)) a barrier material between a first film and a second film in a configuration that corresponds to the shape of an inflatable compartment of the inflatable bladder; (b) positioning (20(b)) said first and second films, with said barrier material positioned thereinbetween, between a first ply of material and a second ply of material, wherein at least one of said first and second plies of material is textured; (c) adhering (20(c)) said first film to said second film, except in the vicinity of said barrier material, to form said inflatable bladder having said inflatable compartment surrounded by a sealed, continuously substantially flat perimeter; and (d) removing (20(d)) said first and second plies of material from the inflatable bladder.
A high-strength steel sheet that has a component composition comprising, on a mass percent basis: C: 0.07% to 0.25%, Si: 0.01% to 1.80%, Mn: 1.8% to 3.2%. P: 0.05% or less, S: 0.02% or less, Al: 0.01% to 2.0%, and N: 0.01% or less; at least one of B: 0.0001% to 0.005%, Ti: 0.005% to 0.04%, and Nb: 0.005% to 0.06%; optionally at least one of Mo: 0.03% to 0.50% and Cr: 0.1% to 1.0% in a total of 1% or less, optionally a total of 0.5% or less of at least one of Cu, Ni, Sn, As, Sb, Ca, Mg, Pb, Co, Ta, W, REM, Zn, V, Sr, Cs, and Hf, and a balance being Fe and incidental impurities, that has a steel microstructure in which an area percentage of ferrite ranges from 5% to 50% in a thickness cross-section in a rolling direction, a total area percentage of fresh martensite and retained γ ranges from 2% to 30%, each of the fresh martensite and the retained γ has an average grain size of 5 μm or less, and a ratio of the fresh martensite and the retained γ adjacent only to ferrite with respect to the fresh martensite and the retained γ from a surface to 200 μm in the thickness direction is 30% or less in total area percentage, wherein residual microstructures include tempered martensite, bainite and pearlite in an amount of 93% or less, wherein tempered martensite may range from 40% to 85% and bainite and pearlite may be 16% or less in total, wherein the high-strength steel sheet has a yield strength of 550 MPa or more, wherein the yield strength, the area percentage of ferrite, the total area percentage of fresh martensite and retained γ, the average grain size of the fresh martensite and the retained γ, the ratio of the fresh martensite and the retained γ adjacent only to ferrite with respect to the fresh martensite and the retained γ as well as the percentage of tempered martensite and the total percentage of bainite and pearlite are determined in accordance with the specifics given in the description. C: 0.07% to 0.25%, Si: 0.01% to 1.80%, Mn: 1.8% to 3.2%. P: 0.05% or less, S: 0.02% or less, Al: 0.01% to 2.0%, and N: 0.01% or less; at least one of B: 0.0001% to 0.005%, Ti: 0.005% to 0.04%, and Nb: 0.005% to 0.06%; optionally at least one of Mo: 0.03% to 0.50% and Cr: 0.1% to 1.0% in a total of 1% or less, optionally a total of 0.5% or less of at least one of Cu, Ni, Sn, As, Sb, Ca, Mg, Pb, Co, Ta, W, REM, Zn, V, Sr, Cs, and Hf, and a balance being Fe and incidental impurities, that has a steel microstructure in which an area percentage of ferrite ranges from 5% to 50% in a thickness cross-section in a rolling direction, a total area percentage of fresh martensite and retained γ ranges from 2% to 30%, each of the fresh martensite and the retained γ has an average grain size of 5 μm or less, and a ratio of the fresh martensite and the retained γ adjacent only to ferrite with respect to the fresh martensite and the retained γ from a surface to 200 μm in the thickness direction is 30% or less in total area percentage,
A fan drive gear system for a turbofan engine comprising: a sun gear rotatable about an axis; a plurality of intermediate gears driven by the sun gear; and a baffle (80; 160) disposed between at least two of the plurality of intermediate gears for defining a lubricant flow path from an interface between the sun gear and at least one of the plurality of intermediate gears, the baffle (80; 160) including a channel (96; 165) with a first ramp portion (108; 162A) directing lubricant forward and a second ramp portion (110; 162B) directing lubricant aft, wherein the baffle (80; 160) includes an apex (116; 164) between the first ramp portion (108; 162A) and the second ramp portion (110; 162B); characterised in that: the apex (116; 164) is disposed at an inlet opening to the channel (96; 165). a sun gear rotatable about an axis; a plurality of intermediate gears driven by the sun gear; and a baffle (80; 160) disposed between at least two of the plurality of intermediate gears for defining a lubricant flow path from an interface between the sun gear and at least one of the plurality of intermediate gears, the baffle (80; 160) including a channel (96; 165) with a first ramp portion (108; 162A) directing lubricant forward and a second ramp portion (110; 162B) directing lubricant aft, wherein the baffle (80; 160) includes an apex (116; 164) between the first ramp portion (108; 162A) and the second ramp portion (110; 162B); characterised in that: the apex (116; 164) is disposed at an inlet opening to the channel (96; 165).
A motion assistance apparatus (1; 2; 3) comprising: a proximal frame configured to support a proximal part of a user; a connecting frame rotatably connected to the proximal frame; a distal frame rotatably connected to the connecting frame, the distal frame configured to support a distal part of the user; and a power transmitter configured to transmit a power from the proximal frame to the distal frame, wherein the connecting frame is configured to rotate about a rotation axis in a direction traversing a sagittal plane of the user thereby allowing 2-degree of freedom, DOF, rotational motion of the distal frame with respect to the proximal frame; and characterised in that the connecting frame is rotatably connected to each of the proximal frame and the distal frame such that the connecting frame is configured to rotate about the rotation axis in a direction so as to be parallel to the proximal frame, in response to the distal frame rotating in a direction in which an angle between the proximal frame and the distal frame increases. a proximal frame configured to support a proximal part of a user; a connecting frame rotatably connected to the proximal frame; a distal frame rotatably connected to the connecting frame, the distal frame configured to support a distal part of the user; and a power transmitter configured to transmit a power from the proximal frame to the distal frame, wherein the connecting frame is configured to rotate about a rotation axis in a direction traversing a sagittal plane of the user thereby allowing 2-degree of freedom, DOF, rotational motion of the distal frame with respect to the proximal frame; and characterised in that the connecting frame is rotatably connected to each of the proximal frame and the distal frame such that the connecting frame is configured to rotate about the rotation axis in a direction so as to be parallel to the proximal frame, in response to the distal frame rotating in a direction in which an angle between the proximal frame and the distal frame increases.
A roof window having a blind frame and a sash frame that is displaceable relative to the blind frame and carries a glazing, wherein the glazing is supported on a sash frame bar of the sash frame on which a sash frame seal for bridging an air gap present between the blind frame and the sash frame is arranged, wherein the sash frame seal, viewed in cross-section, at least in some regions engages over a blind frame bar of the blind frame when the roof window is closed, characterised in that an insulation block arranged between the blind frame and the sash frame and engaging in the air gap for thermal insulation of the roof window is formed integrally with the sash frame seal, so that the sash frame seal and the insulation block are present as one component.
Method for a first communication partner to create and transmit an asymmetric checksum for a message (m) on a computer-aided basis, in which a processor carries out the following method steps: - computing the asymmetric checksum (c') from a first checksum (c 1) by means of a bijective mapping of a first set (C'), wherein - the first checksum (c 1) is assigned from a set of all possible checksums to the message (m) from a set of all possible messages by means of a first function (F 1), - the first checksum (c 1) is conditioned in particular by virtue of a second function (F 2) mapping the set of all possible checksums onto the first set (C'); - distributing a piece of information that defines an inverse function (G -1) for the bijective mapping to at least one second communication partner, wherein the inverse function (G -1) is used to compute the first checksum (c 1) from the asymmetric checksum (c'); and - transmitting the asymmetric checksum (c') and the message (m) to the at least one second communication partner; characterized in that in addition to the message (m) and the asymmetric checksum (c') the first checksum (c 1) is sent to the second communication partner. - computing the asymmetric checksum (c') from a first checksum (c 1) by means of a bijective mapping of a first set (C'), wherein - the first checksum (c 1) is assigned from a set of all possible checksums to the message (m) from a set of all possible messages by means of a first function (F 1), - the first checksum (c 1) is conditioned in particular by virtue of a second function (F 2) mapping the set of all possible checksums onto the first set (C'); - the first checksum (c 1) is assigned from a set of all possible checksums to the message (m) from a set of all possible messages by means of a first function (F 1), - the first checksum (c 1) is conditioned in particular by virtue of a second function (F 2) mapping the set of all possible checksums onto the first set (C'); - distributing a piece of information that defines an inverse function (G -1) for the bijective mapping to at least one second communication partner, wherein the inverse function (G -1) is used to compute the first checksum (c 1) from the asymmetric checksum (c'); and - transmitting the asymmetric checksum (c') and the message (m) to the at least one second communication partner;
Method for producing rare earth metal-doped quartz glass, comprising the method steps: (a) providing a blank of the rare earth metal-doped quartz glass, and (b) homogenizing the blank by softening the blank zone by zone in a heating zone and by twisting the softened zone along a rotation axis, characterized in that during homogenization according to method step (b) the blank is softened under the action of an oxidizingly acting or neutral plasma. (a) providing a blank of the rare earth metal-doped quartz glass, and (b) homogenizing the blank by softening the blank zone by zone in a heating zone and by twisting the softened zone along a rotation axis,