A method for amplifying nucleic acid molecules, said method comprising: providing a collection of different circular chimeric single-stranded nucleic acid constructs, each construct comprising: a first single stranded segment of original genomic DNA from a host organism and a second single stranded synthetic nucleic acid segment that is linked to the first single stranded segment and comprises a nucleotide sequence that is exogenous to the host organism, said nucleotide sequence comprising a unique identifier portion, wherein the nucleotide sequence of both the unique identifier portion and the segment of original genomic DNA distinguishes one chimeric single-stranded nucleic acid construct in the collection from every other chimeric single-stranded nucleic acid construct in the collection, said chimeric single-stranded nucleic acid constructs of the collection being circularized and suitable for rolling circle amplification and/or sequencing; blending the collection of different circular chimeric single-stranded nucleic acid constructs with a polymerase and a plurality of short primers that are 6 to 10 nucleotides in length and comprise random bases and/or nucleotide analogues, wherein one or more of the short primers is complementary to a portion of one or more circular chimeric single stranded nucleic acid constructs of the collection, whereby said blending forms an amplification reaction mixture; and subjecting the amplification reaction mixture to one or more hybridization and extension treatments, wherein the one or more short primers hybridize to the circular chimeric single-stranded nucleic acid constructs and the polymerase extends the hybridized short primers to produce a plurality of extension products, each extension product comprising two or more tandem linear sequences, wherein each tandem linear sequence is complementary to a chimeric single-stranded nucleic acid construct from the collection. providing a collection of different circular chimeric single-stranded nucleic acid constructs, each construct comprising: a first single stranded segment of original genomic DNA from a host organism and a second single stranded synthetic nucleic acid segment that is linked to the first single stranded segment and comprises a nucleotide sequence that is exogenous to the host organism, said nucleotide sequence comprising a unique identifier portion, wherein the nucleotide sequence of both the unique identifier portion and the segment of original genomic DNA distinguishes one chimeric single-stranded nucleic acid construct in the collection from every other chimeric single-stranded nucleic acid construct in the collection, said chimeric single-stranded nucleic acid constructs of the collection being circularized and suitable for rolling circle amplification and/or sequencing; a first single stranded segment of original genomic DNA from a host organism and a second single stranded synthetic nucleic acid segment that is linked to the first single stranded segment and comprises a nucleotide sequence that is exogenous to the host organism, said nucleotide sequence comprising a unique identifier portion, wherein the nucleotide sequence of both the unique identifier portion and the segment of original genomic DNA distinguishes one chimeric single-stranded nucleic acid construct in the collection from every other chimeric single-stranded nucleic acid construct in the collection, said chimeric single-stranded nucleic acid constructs of the collection being circularized and suitable for rolling circle amplification and/or sequencing; blending the collection of different circular chimeric single-stranded nucleic acid constructs with a polymerase and a plurality of short primers that are 6 to 10 nucleotides in length and comprise random bases and/or nucleotide analogues, wherein one or more of the short primers is complementary to a portion of one or more circular chimeric single stranded nucleic acid constructs of the collection, whereby said blending forms an amplification reaction mixture; and subjecting the amplification reaction mixture to one or more hybridization and extension treatments, wherein the one or more short primers hybridize to the circular chimeric single-stranded nucleic acid constructs and the polymerase extends the hybridized short primers to produce a plurality of extension products, each extension product comprising two or more tandem linear sequences, wherein each tandem linear sequence is complementary to a chimeric single-stranded nucleic acid construct from the collection.