A compound represented by formula, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: wherein, A ring is substituted or unsubstituted C 3-10 heterocyclic radical, or C 4-10 cycloalkenyl; said substituted or unsubstituted C 3-10 heterocyclic radical is substituted or unsubstituted 9 - 10 membered bicyclic heteroaryl ring containing 1, 2 or 3 nitrogen atoms and is selected from the group consisting of: wherein, Z 11 is CR 15 or N; Z 12 is CR 16 or N; Z 21 is CR 26 or N; R 12, R 13, R 14, R 15, R 16, R 22, R 23, R 24, R 25, R 26 are each independently H, hydroxy, CN, NO 2, halogen, C 1-3 haloalkyl, C 1-3 alkyl, -CON (C 1-3 alkyl) 2, -N(C 1-3 alkyl) 2, -C OC 1-3 alkyl, -OC C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said alkyl and phenyl are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; R 11, R 21 are each independently H, C 1-3 haloalkyl, C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; or said substituted or unsubstituted C 3-10 heterocyclic radical is substituted or unsubstituted 5 - 6 membered monocyclic heteroaryl ring containing 1 - 2 nitrogen atoms and is selected from the group consisting of: wherein, Z 31 is CR 34 or N; R 32, R 33, R 34, R 35, R 36, R 37, and R 38 are each independently H, hydroxy, CN, NO 2, halogen, C 1-3 haloalkyl, C 1-3 alkyl, -CON(C 1-3 alkyl) 2, -N(C 1-3 alkyl) 2, -C OC 1-3 alkyl, -OC C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; R 31 is H, C 1-3 haloalkyl, C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; or said substituted or unsubstituted C 3-10 heterocyclic radical is substituted or unsubstituted 4 - 7 membered saturated monocyclic heterocyclic ring containing one nitrogen atom and is selected from the group consisting of: wherein, n 1 is 1, 2 or 3; n 2 is 1 or 2; R 41 is H, C 1-3 alkyl, C 1-3 haloalkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; X is a covalent bond, or NH, O or S; R 0 is H, C 1-3 alkyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, C 3-6 halocycloalkyl, -CHO, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; R 1, R 2 are each independently H, halogen, C 1-3 alkyl, C 1-3 haloalkyl; R 3 is selected from the group consisting of: wherein, said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: halogen, C 1-3 alkyl. wherein, Z 11 is CR 15 or N; Z 12 is CR 16 or N; Z 21 is CR 26 or N; R 12, R 13, R 14, R 15, R 16, R 22, R 23, R 24, R 25, R 26 are each independently H, hydroxy, CN, NO 2, halogen, C 1-3 haloalkyl, C 1-3 alkyl, -CON (C 1-3 alkyl) 2, -N(C 1-3 alkyl) 2, -C OC 1-3 alkyl, -OC C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said alkyl and phenyl are unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; R 11, R 21 are each independently H, C 1-3 haloalkyl, C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; wherein, Z 31 is CR 34 or N; R 32, R 33, R 34, R 35, R 36, R 37, and R 38 are each independently H, hydroxy, CN, NO 2, halogen, C 1-3 haloalkyl, C 1-3 alkyl, -CON(C 1-3 alkyl) 2, -N(C 1-3 alkyl) 2, -C OC 1-3 alkyl, -OC C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; R 31 is H, C 1-3 haloalkyl, C 1-3 alkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; wherein, n 1 is 1, 2 or 3; n 2 is 1 or 2; R 41 is H, C 1-3 alkyl, C 1-3 haloalkyl, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl, -S C 1-3 alkyl, -S -phenyl; said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: fluorine, chlorine, methyl; X is a covalent bond, or NH, O or S; R 0 is H, C 1-3 alkyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, C 3-6 halocycloalkyl, -CHO, -COC 1-3 alkyl, -CO-phenyl, -SO 2 C 1-3 alkyl, -SO 2 -phenyl; R 1, R 2 are each independently H, halogen, C 1-3 alkyl, C 1-3 haloalkyl; R 3 is selected from the group consisting of: wherein, said phenyl is unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of: halogen, C 1-3 alkyl.