A computer-implemented method of processing information to assist interventional instrument guidance using a processed target location within a patient anatomy and a received position and orientation for a tip portion of an interventional instrument at a first location within the patient anatomy, the method comprising: determining a three-dimensional distance between the first location and the target location; and displaying, on a graphical user interface in a first window of a display, an image that includes a symbol (402, 502) representing the target location, a symbol (400, 500) representing the tip portion of the interventional instrument, and a rotational assist symbol (418, 518) indicating a rotational orientation of a deployment feature of the tip portion; characterized in that: the image further includes a symbol (404, 504) representing a direction between the tip portion of the interventional instrument and the target location that also extends between the symbol representing the tip portion of the interventional instrument and the symbol representing the target location; the method further comprises displaying, on the graphical user interface in a second window of the display, a secondary guidance image, the secondary guidance image comprising one of the following: an endoscopic camera image, a virtual endoscopic image, a pre-operative image of the patient anatomy with a mark at the target location, and a virtual pathway image; and the secondary guidance image rotates to reflect an orientation of the tip portion. determining a three-dimensional distance between the first location and the target location; and displaying, on a graphical user interface in a first window of a display, an image that includes a symbol (402, 502) representing the target location, a symbol (400, 500) representing the tip portion of the interventional instrument, and a rotational assist symbol (418, 518) indicating a rotational orientation of a deployment feature of the tip portion; characterized in that: the image further includes a symbol (404, 504) representing a direction between the tip portion of the interventional instrument and the target location that also extends between the symbol representing the tip portion of the interventional instrument and the symbol representing the target location; the method further comprises displaying, on the graphical user interface in a second window of the display, a secondary guidance image, the secondary guidance image comprising one of the following: an endoscopic camera image, a virtual endoscopic image, a pre-operative image of the patient anatomy with a mark at the target location, and a virtual pathway image; and the secondary guidance image rotates to reflect an orientation of the tip portion. the image further includes a symbol (404, 504) representing a direction between the tip portion of the interventional instrument and the target location that also extends between the symbol representing the tip portion of the interventional instrument and the symbol representing the target location; the method further comprises displaying, on the graphical user interface in a second window of the display, a secondary guidance image, the secondary guidance image comprising one of the following: an endoscopic camera image, a virtual endoscopic image, a pre-operative image of the patient anatomy with a mark at the target location, and a virtual pathway image; and the secondary guidance image rotates to reflect an orientation of the tip portion.