A system for splitting a fluid, comprising: a source support configured to support a source container of a fluid flow circuit; a satellite support (20a, 20b) configured to support a satellite container (22, 24) of the fluid flow circuit fluidly connected to the source container; a weight scale associated with each of the supports (14, 20a, 20b); a clamp system; and a controller configured to receive an input corresponding to a concentration or an amount of a constituent in a fluid to be split, control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale, determine a plurality of possible distributions of the fluid to be split between the source container and the satellite container (22, 24) based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, and control the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container (22, 24) so as to distribute the fluid to be split between the source container and the satellite container (22, 24) according to one of said plurality of possible distributions, wherein at least one of said plurality of possible distributions is an uneven distribution of the fluid to be split. a source support configured to support a source container of a fluid flow circuit; a satellite support (20a, 20b) configured to support a satellite container (22, 24) of the fluid flow circuit fluidly connected to the source container; a weight scale associated with each of the supports (14, 20a, 20b); a clamp system; and a controller configured to receive an input corresponding to a concentration or an amount of a constituent in a fluid to be split, control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale, determine a plurality of possible distributions of the fluid to be split between the source container and the satellite container (22, 24) based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, and control the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container (22, 24) so as to distribute the fluid to be split between the source container and the satellite container (22, 24) according to one of said plurality of possible distributions, wherein at least one of said plurality of possible distributions is an uneven distribution of the fluid to be split. receive an input corresponding to a concentration or an amount of a constituent in a fluid to be split, control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale, determine a plurality of possible distributions of the fluid to be split between the source container and the satellite container (22, 24) based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, and control the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container (22, 24) so as to distribute the fluid to be split between the source container and the satellite container (22, 24) according to one of said plurality of possible distributions, wherein at least one of said plurality of possible distributions is an uneven distribution of the fluid to be split.