A system for high throughput screening of fluidic samples, the system comprising: a first valve coupled to a sipper, a vacuum, a wash solution pump, and a sample loop; and a second valve coupled to the first valve, an elution solvent pump, a chromatography column, a waste port, and an optical interrogator or a mass spectrometer; wherein the first valve is configured for actuation to: a first position, wherein the sample loop is in communication with the vacuum and the sipper, and wherein the wash solution pump is in communication with the second valve; and a second position, wherein the sample loop is in communication with the wash solution pump and the second valve, and wherein the sipper is in communication with the vacuum; wherein the second valve is configured for actuation to: a first position, wherein the chromatography column is in communication with the first valve and the waste port, and wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump; and a second position, wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump via the chromatography column, and wherein the waste port is in communication with the first valve; wherein for filling the sample loop and flushing the chromatography column and the optical interrogator or the mass spectrometer, the system is configured to actuate the first valve to the first position and the second valve to the first position; wherein for delivering the sample loop's contents to the chromatography column in a first direction and for cleaning the sipper, the system is configured to actuate the first valve to the second position and the second valve to the first position; and wherein for flowing the elution solvent over the chromatography column in a second direction and presenting the elution solvent and an eluted sample to the optical interrogator or the mass spectrometer and for washing the sample loop, the system is configured to actuate the first valve to the second position and the second valve to the second position. a first valve coupled to a sipper, a vacuum, a wash solution pump, and a sample loop; and a second valve coupled to the first valve, an elution solvent pump, a chromatography column, a waste port, and an optical interrogator or a mass spectrometer; wherein the first valve is configured for actuation to: a first position, wherein the sample loop is in communication with the vacuum and the sipper, and wherein the wash solution pump is in communication with the second valve; and a second position, wherein the sample loop is in communication with the wash solution pump and the second valve, and wherein the sipper is in communication with the vacuum; a first position, wherein the sample loop is in communication with the vacuum and the sipper, and wherein the wash solution pump is in communication with the second valve; and a second position, wherein the sample loop is in communication with the wash solution pump and the second valve, and wherein the sipper is in communication with the vacuum; wherein the second valve is configured for actuation to: a first position, wherein the chromatography column is in communication with the first valve and the waste port, and wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump; and a second position, wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump via the chromatography column, and wherein the waste port is in communication with the first valve; a first position, wherein the chromatography column is in communication with the first valve and the waste port, and wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump; and a second position, wherein the optical interrogator or the mass spectrometer is in communication with the elution solvent pump via the chromatography column, and wherein the waste port is in communication with the first valve; wherein for filling the sample loop and flushing the chromatography column and the optical interrogator or the mass spectrometer, the system is configured to actuate the first valve to the first position and the second valve to the first position; wherein for delivering the sample loop's contents to the chromatography column in a first direction and for cleaning the sipper, the system is configured to actuate the first valve to the second position and the second valve to the first position; and