A system for collecting plasma, comprising: a venipuncture needle configured to draw whole blood from a donor; a blood separator configured to separate the whole blood into a plasma product and a second blood component comprising red blood cells, the blood separator having a plasma output port coupled to a plasma line configured to send the plasma product to a plasma product collection container; a donor line fluidly coupled to the venipuncture needle configured to introduce the whole blood from the donor to the separator, flow through the donor line being controlled by a first pump; an anticoagulant line coupled to an anticoagulant source, the anticoagulant line configured to combine anticoagulant with the whole blood from the donor, flow through the anticoagulant line being controlled by a second pump; a touchscreen configured to receive input from an operator; and a controller configured to control operation of the system, the controller configured to receive donor parameters for a plasma collection procedure over a network from a remote database, the remote database comprising a donor management system used for donor screening prior to a donation, donor recruitment and/or donor record management, wherein the controller is further configured to receive a user input via the touchscreen to confirm at least one of the parameters and/or the procedure, to determine a target volume for plasma product and/or raw plasma which is based at least in part on at least one of the parameters received over the network from the remote database and, in response to confirming the at least one of the parameters and/or the procedure, to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the second blood component and to return the second blood component to the donor, wherein the donor parameters received electronically from the remote database comprise a donor weight, and characterized in that the controller is configured to determine the target volume for plasma product and/or raw plasma based at least in part on the donor weight, a venipuncture needle configured to draw whole blood from a donor; a blood separator configured to separate the whole blood into a plasma product and a second blood component comprising red blood cells, the blood separator having a plasma output port coupled to a plasma line configured to send the plasma product to a plasma product collection container; a donor line fluidly coupled to the venipuncture needle configured to introduce the whole blood from the donor to the separator, flow through the donor line being controlled by a first pump; an anticoagulant line coupled to an anticoagulant source, the anticoagulant line configured to combine anticoagulant with the whole blood from the donor, flow through the anticoagulant line being controlled by a second pump; a touchscreen configured to receive input from an operator; and a controller configured to control operation of the system, the controller configured to receive donor parameters for a plasma collection procedure over a network from a remote database, the remote database comprising a donor management system used for donor screening prior to a donation, donor recruitment and/or donor record management, wherein the controller is further configured to receive a user input via the touchscreen to confirm at least one of the parameters and/or the procedure, to determine a target volume for plasma product and/or raw plasma which is based at least in part on at least one of the parameters received over the network from the remote database and, in response to confirming the at least one of the parameters and/or the procedure, to control the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the second blood component and to return the second blood component to the donor, wherein the donor parameters received electronically from the remote database comprise a donor weight, and characterized in that the controller is configured to determine the target volume for plasma product and/or raw plasma based at least in part on the donor weight,