A new cytidine derivative, having the following general formula: wherein, R1 is C 1 -C 10 alkyl, C 1 -C 10 substituted alkyl, -(CH 2)n-Ph, or substituted -(CH 2)n-Ph; wherein in said -(CH 2)n-Ph, n = 0, 1, 2, 3 to 10, Ph is phenyl; a carbon chain of said substituted alkyl is independently substituted by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; in said substituted -(CH 2)n-Ph, n = 0, 1, 2, 3 to 10, and a carbon chain or a phenyl ring of which is independently substituted by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; R2 is wherein X1 is C 1 -C 10 alkyl, C 1 -C 10 substituted alkyl, C 1 -C 10 alkoxy, C 1 -C 10 substituted alkoxy, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylthiol, -(CH 2)n-Ph, or substituted -(CH 2)n-Ph; wherein a carbon chain of said substituted alkyl is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; a carbon chain of said substituted alkoxy is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; in said (CH 2) n-Ph, n = 0, 1, 2, 3 to 10; in said substituted (CH 2) n-Ph, n = 0, 1, 2, 3 to 10, and a carbon chain or a phenyl ring of which is substituted by one or two or three H, halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; R3 is H wherein X3 is phenyl ring, heterocyclic ring, fused heterocyclic ring, substituted phenyl that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group, substituted heterocyclic ring that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group, or substituted fused heterocyclic ring that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; wherein said heterocyclic ring is imidazole, pyridine, furan, thiophene, thiazole, pyrimidine, piperazine or piperidine; said fused heterocyclic ring is quinoline or indole; and X2 is -(CH 2)n-, wherein n = 1, 2, 3, or X2 is -O-(CH 2) n-, wherein n = 0, 1, 2, 3. wherein, R1 is C 1 -C 10 alkyl, C 1 -C 10 substituted alkyl, -(CH 2)n-Ph, or substituted -(CH 2)n-Ph; wherein in said -(CH 2)n-Ph, n = 0, 1, 2, 3 to 10, Ph is phenyl; a carbon chain of said substituted alkyl is independently substituted by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; in said substituted -(CH 2)n-Ph, n = 0, 1, 2, 3 to 10, and a carbon chain or a phenyl ring of which is independently substituted by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; R2 is wherein X1 is C 1 -C 10 alkyl, C 1 -C 10 substituted alkyl, C 1 -C 10 alkoxy, C 1 -C 10 substituted alkoxy, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylthiol, -(CH 2)n-Ph, or substituted -(CH 2)n-Ph; wherein a carbon chain of said substituted alkyl is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; a carbon chain of said substituted alkoxy is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; in said (CH 2) n-Ph, n = 0, 1, 2, 3 to 10; in said substituted (CH 2) n-Ph, n = 0, 1, 2, 3 to 10, and a carbon chain or a phenyl ring of which is substituted by one or two or three H, halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; R3 is H wherein X3 is phenyl ring, heterocyclic ring, fused heterocyclic ring, substituted phenyl that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group, substituted heterocyclic ring that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group, or substituted fused heterocyclic ring that is substituted independently by one or two or three halogen, cyano group, nitro group, amino group, hydroxyl group or carboxyl group; wherein said heterocyclic ring is imidazole, pyridine, furan, thiophene, thiazole, pyrimidine, piperazine or piperidine; said fused heterocyclic ring is quinoline or indole; and X2 is -(CH 2)n-, wherein n = 1, 2, 3, or X2 is -O-(CH 2) n-, wherein n = 0, 1, 2, 3.