mhurhangee/ep-ind-claims huggingface dataset:
A liposomal antifolate composition comprising: a liposome including an interior space; a bioactive antifolate agent disposed within said interior space; a PEG attached to an exterior of the liposome; a protein with specific affinity for at least one folate receptor, said protein attached to at least one of the PEG and the exterior of the liposome; and wherein the liposome has a zeta potential that is less than or equal to zero and the liposome is anionic or neutral. a liposome including an interior space; a bioactive antifolate agent disposed within said interior space; a PEG attached to an exterior of the liposome; a protein with specific affinity for at least one folate receptor, said protein attached to at least one of the PEG and the exterior of the liposome; and wherein the liposome has a zeta potential that is less than or equal to zero and the liposome is anionic or neutral.
A combination of sepetaprost, a hydrate thereof or a solvate thereof, and a Rho-associated coiled-coil containing protein kinase inhibitor(s), for use in the prophylaxis or treatment for glaucoma or ocular hypertension, wherein the Rho-associated coiled-coil containing protein kinase inhibitor(s) is at least one kind selected from the group consisting of ripasudil, a salt thereof, a hydrate thereof and a solvate thereof.
Method for operating a switching element, comprising the following steps: determining a temperature (Tmp) of the switching element, operating the switching element depending on the determined temperature (Tmp); determining a permissible load current (Iz) through the switching element depending on the determined temperature (Tmp), wherein the switching element is operated using a load current that is not greater than the permissible load current (Iz); characterized by the further steps of: comparing the determined temperature (Tmp) with a temperature threshold value (Tsw), actively heating the switching element as long as the determined temperature (Tmp) is lower than the temperature threshold value (Tsw). determining a temperature (Tmp) of the switching element, operating the switching element depending on the determined temperature (Tmp); determining a permissible load current (Iz) through the switching element depending on the determined temperature (Tmp), wherein the switching element is operated using a load current that is not greater than the permissible load current (Iz); characterized by the further steps of: comparing the determined temperature (Tmp) with a temperature threshold value (Tsw), actively heating the switching element as long as the determined temperature (Tmp) is lower than the temperature threshold value (Tsw). comparing the determined temperature (Tmp) with a temperature threshold value (Tsw), actively heating the switching element as long as the determined temperature (Tmp) is lower than the temperature threshold value (Tsw).
A centrifugal filtration device, for separating living cells, characterized by comprising a spindle, a rotary arm which is connected perpendicularly to the spindle axis to the spindle and capable of rotating as the spindle rotates to produce centrifugal force, and a microporous membrane filter which is mounted on the rotary arm; - wherein the microporous membrane filter comprises an inlet, an outlet, a front cavity having the inlet formed thereon, a rear cavity having the outlet formed thereon, and a filter membrane arranged between the front cavity and the rear cavity; the diameter of the filter pore of the filter membrane is 1-30 μm; - the inlet and the front cavity are arranged on a far end referring to the rotary arm, and the outlet and the rear cavity are arranged on a near end referring to the rotary arm; - the inlet is arranged at the top or a sidewall of the front cavity, and the outlet is arranged at the bottom or a sidewall of the rear cavity. - wherein the microporous membrane filter comprises an inlet, an outlet, a front cavity having the inlet formed thereon, a rear cavity having the outlet formed thereon, and a filter membrane arranged between the front cavity and the rear cavity; the diameter of the filter pore of the filter membrane is 1-30 μm; - the inlet and the front cavity are arranged on a far end referring to the rotary arm, and the outlet and the rear cavity are arranged on a near end referring to the rotary arm; - the inlet is arranged at the top or a sidewall of the front cavity, and the outlet is arranged at the bottom or a sidewall of the rear cavity.
A method for transferring data between a first solid state drive, SSD, and a second SSD, the first SSD having a first built-in network interface device configured to communicate via a network fabric, and the second SSD having a second built-in network interface device configured to communicate via the network fabric, the method comprising: opening a connection between the first SSD and the second SSD over a network fabric; based on a non-volatile memory over fabric, NVMe-oF, communication protocol, encapsulating in a capsule an NVMe command to transfer data between the first SSD and the second SSD over the connection; sending the capsule from the first SSD to the second SSD over the connection via the network fabric; executing, by the second SSD, the NVMe command in the capsule to transfer the data between the first SSD and the second SSD over the connection; and sending to the second SSD, by the first SSD, an indication of a data rate that the second SSD is to use when communicating with a host computer that is communicatively coupled to the network fabric, including sending the indication of the data rate to the second SSD via the network fabric. opening a connection between the first SSD and the second SSD over a network fabric; based on a non-volatile memory over fabric, NVMe-oF, communication protocol, encapsulating in a capsule an NVMe command to transfer data between the first SSD and the second SSD over the connection; sending the capsule from the first SSD to the second SSD over the connection via the network fabric; executing, by the second SSD, the NVMe command in the capsule to transfer the data between the first SSD and the second SSD over the connection; and sending to the second SSD, by the first SSD, an indication of a data rate that the second SSD is to use when communicating with a host computer that is communicatively coupled to the network fabric, including sending the indication of the data rate to the second SSD via the network fabric.
Recoverable temporary traverse applicable in the construction of railway tracks on plates with rails that are not interconnected and anchored by means of block or plate supports with inserts, and intended to attach and position in a given space rails provided with a head and a foot defining a running surface and forming a track and anchoring supports thereof while performing a mounting, levelling and alignment process of the track and pouring and hardening on a concrete base a setting concrete that will definitively secure said track in a position, characterized in that it comprises: - a main supporting structure intended to be placed between the rails perpendicularly to the axis of the track, said main structure having, at its opposite ends, upper housings wherein at least one portion of the heads of the rails are inserted and are laterally and vertically supported, and lower housings wherein at least one portion of the feet of the respective rails are laterally and vertically supported in a given position, said main structure having at least two anchoring systems for temporary attaching secondary parts; - at least two secondary parts having: a lower wing provided with a housing or the like for temporary attachment to at least one anchoring system of respective lateral end of the main structure and intended to be positioned beneath the corresponding rail without interference with a running surface of the track, and an vertical wing arranged on the outer side of the corresponding rail, - tightening mechanisms mounted on the vertical wings of the secondary parts and intended to push the rails from the outer side of the track against the housings (3, 4) of the main structure; said main structure determining, in the pushing operating position of the tightening mechanisms, the track gauge and the inclination of the rails with respect to the running surface. - a main supporting structure intended to be placed between the rails perpendicularly to the axis of the track, said main structure having, at its opposite ends, upper housings wherein at least one portion of the heads of the rails are inserted and are laterally and vertically supported, and lower housings wherein at least one portion of the feet of the respective rails are laterally and vertically supported in a given position, said main structure having at least two anchoring systems for temporary attaching secondary parts; - at least two secondary parts having: a lower wing provided with a housing or the like for temporary attachment to at least one anchoring system of respective lateral end of the main structure and intended to be positioned beneath the corresponding rail without interference with a running surface of the track, and an vertical wing arranged on the outer side of the corresponding rail, - tightening mechanisms mounted on the vertical wings of the secondary parts and intended to push the rails from the outer side of the track against the housings (3, 4) of the main structure; said main structure determining, in the pushing operating position of the tightening mechanisms, the track gauge and the inclination of the rails with respect to the running surface.
Air spring system for a vehicle, comprising an air spring, and a control unit, wherein the air spring comprises: a first mounting element for being fixed to a vehicle's chassis, a second mounting element for being fixed to a movable part of a vehicle being movable with respect to the chassis, a bellow extending from the first mounting element to the second mounting element and including an air volume, a sensor arrangement being arranged within the air volume, wherein the sensor arrangement is adapted for sensing at least one of a road condition, a vehicle condition and a pay load condition, wherein the control unit is adapted for receiving sensed signals from the sensor arrangement of the air spring, characterized in that the sensor arrangement comprises at least two sensors, wherein the sensors are arranged at least at one of the first mounting element and/or the second mounting element and the sensor arrangement is configured to determine vibrations of the vehicle chassis and/or to determine vibrations of the wheel or the wheel suspension, whereby the control unit is adapted to evaluate the sensed signals upon at least one of a road condition, a vehicle condition and a pay load condition, wherein the control unit is adapted for conducting a signal profile analysis based on the sensed signals and correlations thereof, wherein the control unit is adapted for comparing the sensed signals and correlations thereof with known signal profiles as to identify and recognize the current signal profile. a first mounting element for being fixed to a vehicle's chassis, a second mounting element for being fixed to a movable part of a vehicle being movable with respect to the chassis, a bellow extending from the first mounting element to the second mounting element and including an air volume, a sensor arrangement being arranged within the air volume, wherein the sensor arrangement is adapted for sensing at least one of a road condition, a vehicle condition and a pay load condition, wherein the control unit is adapted for receiving sensed signals from the sensor arrangement of the air spring, characterized in that the sensor arrangement comprises at least two sensors, wherein the sensors are arranged at least at one of the first mounting element and/or the second mounting element and the sensor arrangement is configured to determine vibrations of the vehicle chassis and/or to determine vibrations of the wheel or the wheel suspension, whereby the control unit is adapted to evaluate the sensed signals upon at least one of a road condition, a vehicle condition and a pay load condition, wherein the control unit is adapted for conducting a signal profile analysis based on the sensed signals and correlations thereof, wherein the control unit is adapted for comparing the sensed signals and correlations thereof with known signal profiles as to identify and recognize the current signal profile.
Method for releasing locally assignable useful data, in particular navigation data, which are stored on a data storage medium or are transmitted to a data processing system, the data being released for an area which can be selected by the user of the useful data, characterized in that the useful data are released for an area which is stipulated by the user by - specifying a centre and a radius as a circular area or - stipulating particular corner points. - specifying a centre and a radius as a circular area or - stipulating particular corner points.
A leg pad assembly for a safety harness, the leg pad assembly comprising: a pair of leg pad portions structured to receive leg straps of the safety harness; a central pad portion connecting the pair of leg pad portions and structured to receive a seat strap of the safety harness; characterized in that said leg pad assembly further comprises: a pair of handles, wherein each handle is attached to a respective one of the pair of leg pad portions; and elastic cording attached to each of the pair of handles and being structured to bias the pair of handles toward each other and against the pair of leg pad portions. a pair of leg pad portions structured to receive leg straps of the safety harness; a central pad portion connecting the pair of leg pad portions and structured to receive a seat strap of the safety harness; characterized in that said leg pad assembly further comprises: a pair of handles, wherein each handle is attached to a respective one of the pair of leg pad portions; and elastic cording attached to each of the pair of handles and being structured to bias the pair of handles toward each other and against the pair of leg pad portions. a pair of handles, wherein each handle is attached to a respective one of the pair of leg pad portions; and elastic cording attached to each of the pair of handles and being structured to bias the pair of handles toward each other and against the pair of leg pad portions.
A method of interrogating an optical sensing system performed at an interrogation system, comprising the steps of: receiving a plurality of bursts of samples of an optical signal, each burst of samples comprising a plurality of samples of each pulse in a group of discrete optical pulses returning from optical sensors, wherein the groups are regularly spaced in time with a group repetition period larger than the group width, and the optical pulses comprise a phase modulated signal; processing the bursts of samples to obtain a series of regularly spaced samples at a rate equivalent to an average sample rate (F av) of the optical signal over the group repetition period; and demodulating the regularly spaced samples to retrieve the phase information from the detected pulses, wherein the step of processing comprises the steps of: downsampling the received samples at a downsampling ratio equal to the sample rate in each burst divided by the group repetition frequency, upsampling the downsampled samples, filtering the upsampled samples, and combining the filtered samples. receiving a plurality of bursts of samples of an optical signal, each burst of samples comprising a plurality of samples of each pulse in a group of discrete optical pulses returning from optical sensors, wherein the groups are regularly spaced in time with a group repetition period larger than the group width, and the optical pulses comprise a phase modulated signal; processing the bursts of samples to obtain a series of regularly spaced samples at a rate equivalent to an average sample rate (F av) of the optical signal over the group repetition period; and demodulating the regularly spaced samples to retrieve the phase information from the detected pulses, wherein the step of processing comprises the steps of: downsampling the received samples at a downsampling ratio equal to the sample rate in each burst divided by the group repetition frequency, upsampling the downsampled samples, filtering the upsampled samples, and combining the filtered samples. downsampling the received samples at a downsampling ratio equal to the sample rate in each burst divided by the group repetition frequency, upsampling the downsampled samples, filtering the upsampled samples, and combining the filtered samples.
A method of forming a component having an internal passage defined therein, said method comprising: positioning a jacketed core with respect to a mold, wherein the jacketed core includes: a hollow structure formed from at least a first material and a second material; and an inner core disposed within the hollow structure; introducing a component material in a molten state into a cavity of the mold; and cooling the component material in the cavity to form the component, wherein the inner core defines the internal passage within the component, characterized in that a shape of the internal passage defines at least one stress concentration region in the component, and wherein at least one portion of the hollow structure corresponding to the at least one stress concentration region is at least partially formed from the second material, said introducing the component material into the cavity comprises introducing the component material such that, after the component is formed, the second material forms at least a portion of the at least one stress concentration region. positioning a jacketed core with respect to a mold, wherein the jacketed core includes: a hollow structure formed from at least a first material and a second material; and an inner core disposed within the hollow structure; a hollow structure formed from at least a first material and a second material; and an inner core disposed within the hollow structure; introducing a component material in a molten state into a cavity of the mold; and cooling the component material in the cavity to form the component, wherein the inner core defines the internal passage within the component, characterized in that a shape of the internal passage defines at least one stress concentration region in the component, and wherein at least one portion of the hollow structure corresponding to the at least one stress concentration region is at least partially formed from the second material, said introducing the component material into the cavity comprises introducing the component material such that, after the component is formed, the second material forms at least a portion of the at least one stress concentration region.
A steering mechanism of a drawn vehicle for steering one or more turnable steered axles (2,41) of the drawn vehicle by the mutual bending movement between the drawn vehicle and the towing vehicle or tractor unit when making a turn, characterised in that it at least has: • A slewing bearing with a first slewing bearing part and a second slewing bearing part that are turnable with respect to one another, whereby the first slewing bearing part can be coupled to the drawn vehicle and the second slewing bearing part can be coupled to a tractor unit. • A control for steering the aforementioned axles consisting of a rocker and a support that can be coupled to the drawn vehicle, whereby the support at least contains a vertical shaft around which the rocker is rotatably affixed. • A cable whose first end is connected to a first side of the rocker and whose second end is connected to a second side of the rocker, whereby the vertical shaft of the control is located between the aforementioned first side and second side of the rocker, whereby an interjacent part of the cable is affixed around the second bearing part to transmit a turn of the second slewing bearing part to a turn of the rocker; and, • A tackle (17,18) at each end (12,14) of the cable, consisting of two or more pulleys (19,20), where at least one pulley of each tackle (17,18) can be coupled to the drawn vehicle, hereinafter termed the fixed pulley, and at least one pulley of each tackle (17,18) is on the rocker, hereinafter termed the movable pulley, and where a part of the cable between each end (12,14) and the interjacent part of the cable is guided over the pulleys (17,18) of the tackle concerned (17,18). • A slewing bearing with a first slewing bearing part and a second slewing bearing part that are turnable with respect to one another, whereby the first slewing bearing part can be coupled to the drawn vehicle and the second slewing bearing part can be coupled to a tractor unit. • A control for steering the aforementioned axles consisting of a rocker and a support that can be coupled to the drawn vehicle, whereby the support at least contains a vertical shaft around which the rocker is rotatably affixed. • A cable whose first end is connected to a first side of the rocker and whose second end is connected to a second side of the rocker, whereby the vertical shaft of the control is located between the aforementioned first side and second side of the rocker, whereby an interjacent part of the cable is affixed around the second bearing part to transmit a turn of the second slewing bearing part to a turn of the rocker; and, • A tackle (17,18) at each end (12,14) of the cable, consisting of two or more pulleys (19,20), where at least one pulley of each tackle (17,18) can be coupled to the drawn vehicle, hereinafter termed the fixed pulley, and at least one pulley of each tackle (17,18) is on the rocker, hereinafter termed the movable pulley, and where a part of the cable between each end (12,14) and the interjacent part of the cable is guided over the pulleys (17,18) of the tackle concerned (17,18).