A wrist prosthesis to replace at least a portion of a bone forming a portion of a wrist of a patient, comprising: a radial portion operable to be connected to a radius, the radial portion includes a stem member extending between a first end and a second end, wherein the second end is operable to extend into the radius and an articulation assembly operable to be interconnected with the stem member to replace a resected portion of the radius of the patient, the articulating assembly including: an articulation portion operable to articulate with a carpal bearing portion (2220, 56); a stem connection portion formed near the articulation portion to interconnect with the first end of the stem member to be held relative to the radius; a bone replacement member operable to be positioned between the stem member and the articulation portion, the bone replacement member defining a bore through which the stem connection portion passes; and a connection portion (2204, 2224) operable to interconnect the bone replacement member and the articulation portion; a carpal bearing portion (2220, 56) operable to be connected to a second bone, wherein the carpal bearing portion (2220, 56) is operable to be positioned next to a carpal complex for movement relative to the radial bone of the articulation portion; wherein the carpal bearing portion (2220, 56) is operable to form an articulation with the articulation assembly; and wherein the carpal bearing portion is one of a first carpal bearing portion including a first member formed of a hard material and a second member formed of a soft material that is softer than the hard material, or a second carpal bearing portion that is formed of a hard material. a radial portion operable to be connected to a radius, the radial portion includes a stem member extending between a first end and a second end, wherein the second end is operable to extend into the radius and an articulation assembly operable to be interconnected with the stem member to replace a resected portion of the radius of the patient, the articulating assembly including: an articulation portion operable to articulate with a carpal bearing portion (2220, 56); a stem connection portion formed near the articulation portion to interconnect with the first end of the stem member to be held relative to the radius; a bone replacement member operable to be positioned between the stem member and the articulation portion, the bone replacement member defining a bore through which the stem connection portion passes; and a connection portion (2204, 2224) operable to interconnect the bone replacement member and the articulation portion; a carpal bearing portion (2220, 56) operable to be connected to a second bone, wherein the carpal bearing portion (2220, 56) is operable to be positioned next to a carpal complex for movement relative to the radial bone of the articulation portion; wherein the carpal bearing portion (2220, 56) is operable to form an articulation with the articulation assembly; and wherein the carpal bearing portion is one of a first carpal bearing portion including a first member formed of a hard material and a second member formed of a soft material that is softer than the hard material, or a second carpal bearing portion that is formed of a hard material. an articulation portion operable to articulate with a carpal bearing portion (2220, 56); a stem connection portion formed near the articulation portion to interconnect with the first end of the stem member to be held relative to the radius; a bone replacement member operable to be positioned between the stem member and the articulation portion, the bone replacement member defining a bore through which the stem connection portion passes; and a connection portion (2204, 2224) operable to interconnect the bone replacement member and the articulation portion; a carpal bearing portion (2220, 56) operable to be connected to a second bone, wherein the carpal bearing portion (2220, 56) is operable to be positioned next to a carpal complex for movement relative to the radial bone of the articulation portion; wherein the carpal bearing portion (2220, 56) is operable to form an articulation with the articulation assembly; and wherein the carpal bearing portion is one of a first carpal bearing portion including a first member formed of a hard material and a second member formed of a soft material that is softer than the hard material, or a second carpal bearing portion that is formed of a hard material.