Method for preparing co-processed excipient granules using a co-rotating twin-screw extruder, the twin screw extruder having at least a conveying zone, a kneading zone and a mixing zone, the method comprising the steps of a. Feeding at least one binder to the conveying zone of the extruder; b. Conveying the binder towards the kneading zone; c. Feeding a solvent into at least one point between the beginning and the end of the conveying zone of the extruder, thereby wetting the binder; d. Kneading the wetted binder in the kneading zone of the extruder to form binder agglomerates; e. Conveying the kneaded, wetted binder agglomerates to the mixing zone; f. Feeding one or more superdisintegrants to the mixing zone, thereby forming agglomerates of binder and the one or more superdisintegrants; g. Collecting the agglomerates of binder and superdisintegrant from the extruder; and h. Drying the agglomerates of binder and superdisintegrant to form the co-processed excipient granules; wherein the binder is selected from the group consisting of (i) disaccharides; (ii) monosaccharides; (iii) polyols; (iv) cellulose derivatives selected from the group consisting of cellulose fibers, microcrystalline cellulose, carboxymethylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, and mixtures thereof; (v) starches; (vi) inorganic salts; and mixtures thereof; and wherein the superdisintegrant is selected from the group consisting of sodium starch glycolate, croscarmellose sodium, crospovidon, low-substituted hydroxypropyl cellulose, soy non-starch polysaccharides, polacrilin potassium, calcium alginate, alginic acid, and mixtures thereof. a. Feeding at least one binder to the conveying zone of the extruder; b. Conveying the binder towards the kneading zone; c. Feeding a solvent into at least one point between the beginning and the end of the conveying zone of the extruder, thereby wetting the binder; d. Kneading the wetted binder in the kneading zone of the extruder to form binder agglomerates; e. Conveying the kneaded, wetted binder agglomerates to the mixing zone; f. Feeding one or more superdisintegrants to the mixing zone, thereby forming agglomerates of binder and the one or more superdisintegrants; g. Collecting the agglomerates of binder and superdisintegrant from the extruder; and h. Drying the agglomerates of binder and superdisintegrant to form the co-processed excipient granules; wherein the binder is selected from the group consisting of (i) disaccharides; (ii) monosaccharides; (iii) polyols; (iv) cellulose derivatives selected from the group consisting of cellulose fibers, microcrystalline cellulose, carboxymethylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, and mixtures thereof; (v) starches; (vi) inorganic salts; and mixtures thereof; (i) disaccharides; (ii) monosaccharides; (iii) polyols; (iv) cellulose derivatives selected from the group consisting of cellulose fibers, microcrystalline cellulose, carboxymethylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, and mixtures thereof; (v) starches; (vi) inorganic salts; and wherein the superdisintegrant is selected from the group consisting of sodium starch glycolate, croscarmellose sodium, crospovidon, low-substituted hydroxypropyl cellulose, soy non-starch polysaccharides, polacrilin potassium, calcium alginate, alginic acid, and mixtures thereof.