A grain-oriented electrical steel sheet, comprising: a base steel sheet which contains Si of 0.50 to 7.00 mass%, Mn of 0.05 to 1.00 mass%, C of 0.005 mass% or less, and N of 0.0050 mass% or less and a remainder thereof is composed of Fe and impurities, wherein the base steel sheet optionally contains in place of some of Fe one or more of the following optional elements in the following respective ranges: Acid-soluble Al: 0.0065 mass% or less, S and Se: 0.001 mass% or less in total, Bi: 0.010 mass% or less, B: 0.0080 mass% or less, Ti: 0.015 mass% or less, Nb: 0.020 mass% or less, V: 0.015 mass% or less, Sn: 0.50 mass% or less, Sb: 0.50 mass% or less, Cr: 0.30 mass% or less, Cu: 0.40 mass% or less, P: 0.50 mass% or less, Ni: 1.00 mass% or less, and Mo: 0.10 mass% or less; an intermediate layer which is disposed on a surface of the base steel sheet and contains a silicon oxide as a main component, the intermediate layer having an Fe content of less than 30 atomic%, a P content of less than 5 atomic%, a Si content of 20 atomic% or more and less than 50 atomic%, an O content of 50 atomic% or more and less than 80 atomic%, and a Mg content of 10 atomic% or less; and an insulation coating which is disposed on a surface of the intermediate layer, wherein a number density of the oxide having a circle-equivalent diameter of 0.1 μm or more is 0.020 pieces/μm 2 or less in a region having the depth of 10 μm from the surface of the base steel sheet toward the inside of the base steel sheet, so that a final-annealed film is substantially not present on a surface of the base steel sheet, and in a surface layer region, a Mn-depletion layer having a valley portion of a Mn content in which a Mn content is lower than an average Mn content of the base steel sheet in a region deeper than the surface layer region is provided, and a Mn-rich layer having a peak portion of a Mn content in which a Mn content is higher than that in the valley portion of the Mn content is provided in a region closer to a surface of the insulation coating than the Mn-depletion layer, whereby the number density of the oxides, the Mn-depletion layer and the Mn-rich layer are determined according to the method described in the description. Acid-soluble Al: 0.0065 mass% or less, S and Se: 0.001 mass% or less in total, Bi: 0.010 mass% or less, B: 0.0080 mass% or less, Ti: 0.015 mass% or less, Nb: 0.020 mass% or less, V: 0.015 mass% or less, Sn: 0.50 mass% or less, Sb: 0.50 mass% or less, Cr: 0.30 mass% or less, Cu: 0.40 mass% or less, P: 0.50 mass% or less, Ni: 1.00 mass% or less, and Mo: 0.10 mass% or less; an intermediate layer which is disposed on a surface of the base steel sheet and contains a silicon oxide as a main component, the intermediate layer having an Fe content of less than 30 atomic%, a P content of less than 5 atomic%, a Si content of 20 atomic% or more and less than 50 atomic%, an O content of 50 atomic% or more and less than 80 atomic%, and a Mg content of 10 atomic% or less; and an insulation coating which is disposed on a surface of the intermediate layer, wherein a number density of the oxide having a circle-equivalent diameter of 0.1 μm or more is 0.020 pieces/μm 2 or less in a region having the depth of 10 μm from the surface of the base steel sheet toward the inside of the base steel sheet, so that a final-annealed film is substantially not present on a surface of the base steel sheet, and in a surface layer region, a Mn-depletion layer having a valley portion of a Mn content in which a Mn content is lower than an average Mn content of the base steel sheet in a region deeper than the surface layer region is provided, and a Mn-rich layer having a peak portion of a Mn content in which a Mn content is higher than that in the valley portion of the Mn content is provided in a region closer to a surface of the insulation coating than the Mn-depletion layer, whereby the number density of the oxides, the Mn-depletion layer and the Mn-rich layer are determined according to the method described in the description.