A method for the enrichment of a selected genomic region, comprising the steps of: a. Selecting a genomic region to be sequenced; b. Providing at least one probe set targeting said genomic region; c. Providing at least a library of nucleic acid fragments, said library comprising at least said selected genomic region, wherein said fragments have a predetermined first average length selected so that at least one flanking region of the selected genomic region is included in one or more fragments and wherein said library comprises fragments including at least a portion of an exon and at least a portion of an intron; d. enriching at least said genomic region in said library through said at least one probe set, to obtain at least one enriched selected genomic region; e. Sequencing said at least one enriched selected genomic region using at least a first sequencing technique, to obtain at least a first sequencing data pool of said selected genomic region; f. Processing said at least first sequencing data pool obtaining at least a first computer readable file including genotypability information of said selected genomic region, wherein said step f. comprises the steps of: f.a. aligning the sequence data pool obtained in said step e. to a reference genome sequence; f.b. determining genomic coordinates of genotypable portions of said selected genomic region; f.c. generating at least a first computer readable file including as genotypability information the genomic coordinates of the genotypable portions of said selected genomic region; wherein said first computer-readable file is in gVCF format; said method further comprising a step of: g. Generating at least a second computer readable file including non-genotypability information of said selected genomic region, based on said at least first computer readable file, wherein said second computer-readable file includes as non-genotypability information the genomic coordinates of the non-genotypable portions of said selected genomic region, and wherein said second computer-readable file is in BED format. a. Selecting a genomic region to be sequenced; b. Providing at least one probe set targeting said genomic region; c. Providing at least a library of nucleic acid fragments, said library comprising at least said selected genomic region, wherein said fragments have a predetermined first average length selected so that at least one flanking region of the selected genomic region is included in one or more fragments and wherein said library comprises fragments including at least a portion of an exon and at least a portion of an intron; d. enriching at least said genomic region in said library through said at least one probe set, to obtain at least one enriched selected genomic region; e. Sequencing said at least one enriched selected genomic region using at least a first sequencing technique, to obtain at least a first sequencing data pool of said selected genomic region; f. Processing said at least first sequencing data pool obtaining at least a first computer readable file including genotypability information of said selected genomic region, wherein said step f. comprises the steps of: f.a. aligning the sequence data pool obtained in said step e. to a reference genome sequence; f.b. determining genomic coordinates of genotypable portions of said selected genomic region; f.c. generating at least a first computer readable file including as genotypability information the genomic coordinates of the genotypable portions of said selected genomic region; wherein said first computer-readable file is in gVCF format; said method further comprising a step of: f.a. aligning the sequence data pool obtained in said step e. to a reference genome sequence; f.b. determining genomic coordinates of genotypable portions of said selected genomic region; f.c. generating at least a first computer readable file including as genotypability information the genomic coordinates of the genotypable portions of said selected genomic region; g. Generating at least a second computer readable file including non-genotypability information of said selected genomic region, based on said at least first computer readable file, wherein said second computer-readable file includes as non-genotypability information the genomic coordinates of the non-genotypable portions of said selected genomic region, and wherein said second computer-readable file is in BED format.