A, preferably self-standing, device (100, 200, 300) for delivery of photobiomodulation to a retinal tissue of an eye of a patient, the device (100, 200, 300) comprising: a housing comprising an interior; an eyebox or an eyepiece, wherein the eyebox or eyepiece is disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyebox or eyepiece; a first light source adapted to produce a first light beam exhibiting a first wavelength peak having a first therapeutic wavelength comprising near infrared light, the first light source being disposed within the housing; and a second light source adapted to produce a second light beam exhibiting a second wavelength peak having a second therapeutic wavelength, the second light source being disposed within the housing, wherein the first wavelength peak is distinct from the second wavelength peak and the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm or the first wavelength peak differs from the second wavelength peak by at least 25 nm; a relay structure configured and arranged to direct the first and second light beams through the eyebox or eyepiece to provide PBM to the retinal tissue of the eye or eyes of the patient; the device being characterized by further comprising an actuator (642, 742) configured and arranged to move at least a portion of the relay structure from at least a first position to at least a second position to adjust the direction of at least one of the light beams, wherein the actuator permits adjustment of a direction of at least one of the light beams from a first eye toward a second eye, or permits finer adjustment of the light beam position. a housing comprising an interior; an eyebox or an eyepiece, wherein the eyebox or eyepiece is disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyebox or eyepiece; a first light source adapted to produce a first light beam exhibiting a first wavelength peak having a first therapeutic wavelength comprising near infrared light, the first light source being disposed within the housing; and a second light source adapted to produce a second light beam exhibiting a second wavelength peak having a second therapeutic wavelength, the second light source being disposed within the housing, wherein the first wavelength peak is distinct from the second wavelength peak and the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm or the first wavelength peak differs from the second wavelength peak by at least 25 nm; a relay structure configured and arranged to direct the first and second light beams through the eyebox or eyepiece to provide PBM to the retinal tissue of the eye or eyes of the patient; the device being characterized by further comprising an actuator (642, 742) configured and arranged to move at least a portion of the relay structure from at least a first position to at least a second position to adjust the direction of at least one of the light beams, wherein the actuator permits adjustment of a direction of at least one of the light beams from a first eye toward a second eye, or permits finer adjustment of the light beam position.