A neuromodulation targeting system facilitating spatial selection of a neuromodulation objective, the system comprising: user-input means for providing user-selectable anatomic-specific inputs via an interactive display representing anatomy of a patient and associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation; and neuromodulation targeting means responsive to user selection of a first anatomic-specific input via the user-input means and comprising a neuromodulation delivery controller and a therapy configurator, the therapy configurator being configured to pass the first anatomic-specific input to the neuromodulation delivery controller, and the neuromodulation delivery controller comprising: a targeting selector for computationally determining a first target region where neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location of the anatomic-specific input, and a neuromodulation parameter selector for configuring and controlling delivery of the neuromodulation therapy to the first target region to produce a first localized clinical effect in the patient at a location corresponding to the first anatomic-specific input, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective, the neuromodulation parameter selector being programmed, or otherwise configured, to computationally determine electrical parameters for neuromodulation to be applied to the first target region. user-input means for providing user-selectable anatomic-specific inputs via an interactive display representing anatomy of a patient and associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation; and neuromodulation targeting means responsive to user selection of a first anatomic-specific input via the user-input means and comprising a neuromodulation delivery controller and a therapy configurator, the therapy configurator being configured to pass the first anatomic-specific input to the neuromodulation delivery controller, and the neuromodulation delivery controller comprising: a targeting selector for computationally determining a first target region where neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location of the anatomic-specific input, and a neuromodulation parameter selector for configuring and controlling delivery of the neuromodulation therapy to the first target region to produce a first localized clinical effect in the patient at a location corresponding to the first anatomic-specific input, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective, the neuromodulation parameter selector being programmed, or otherwise configured, to computationally determine electrical parameters for neuromodulation to be applied to the first target region. a targeting selector for computationally determining a first target region where neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location of the anatomic-specific input, and a neuromodulation parameter selector for configuring and controlling delivery of the neuromodulation therapy to the first target region to produce a first localized clinical effect in the patient at a location corresponding to the first anatomic-specific input, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective, the neuromodulation parameter selector being programmed, or otherwise configured, to computationally determine electrical parameters for neuromodulation to be applied to the first target region.