mhurhangee/ep-ind-claims huggingface dataset:
A method for making a purified polysaccharide packaged in an oxygen reduced environment, the method comprising: (a) providing a polysaccharide, (b) removing at least some impurities from the polysaccharide to obtain an integration ratio of 1 or less, wherein the integration ratio is capable of being evaluated using 1 H NMR spectroscopy by comparing a value of a peak at δ 3.92 ppm through δ 3.94 ppm to a value of a reference peak of about δ 4.5 ppm, (c) drying the polysaccharide to a moisture content of 7% by weight or less, (d) packaging the polysaccharide in less than 2% oxygen by volume, and (e) sterilizing the polysaccharide with ionizing radiation; wherein the sterilized polysaccharide is soluble and has less than a 50% change in solids content after nine months as measured using the Percent Solids Measurement. (a) providing a polysaccharide, (b) removing at least some impurities from the polysaccharide to obtain an integration ratio of 1 or less, wherein the integration ratio is capable of being evaluated using 1 H NMR spectroscopy by comparing a value of a peak at δ 3.92 ppm through δ 3.94 ppm to a value of a reference peak of about δ 4.5 ppm, (c) drying the polysaccharide to a moisture content of 7% by weight or less, (d) packaging the polysaccharide in less than 2% oxygen by volume, and (e) sterilizing the polysaccharide with ionizing radiation; wherein the sterilized polysaccharide is soluble and has less than a 50% change in solids content after nine months as measured using the Percent Solids Measurement.
In vitro use of a compound to maintain a function of platelets related to blood coagulation, wherein the compound is any one of N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyforamide and N-{4-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(formylhydroxyamino)ethyl]benzyl}methanesulfonamide; or a salt thereof, or a solvate thereof.
A method of sample separation in a liquid-liquid system using a device comprising at least one first chamber (11, 21b, 41, 51b, 61) with a U- or V-shaped bottom, wherein at least one aperture (13a, 13b, 23b, 43, 53b, 63) with a diameter within the range of 1 to 100 μm, preferably 1 to 40 μm, is provided in the first chamber and wherein at least the surface of each aperture (13a, 13b, 23b, 43, 53b, 63) is hydrophilized or hydrophobized, wherein the device further comprises a second chamber (12, 22, 42, 52, 62) surrounding the outside of the bottom of the first chamber, said method containing the following steps: - introducing a system containing immiscible liquids into the first chamber with the hydrophilized or hydrophobized surface of at least the aperture of the first chamber, - introducing a fluid sample into the first chamber; this step can be performed together with the step of introducing the system containing immiscible liquids or subsequently to the step of introducing the system containing immiscible liquids, or prior to the step of introducing the system containing immiscible liquids, - optional step of emulsification and subsequent phase stabilization, - application of pressure force on the system in the first chamber causing the liquid fraction having the same chemical hydrophilic or hydrophobic nature, respectively, as the hydrophilic or hydrophobic nature of the aperture surface, respectively, to pass through the aperture into the next chamber, and causing the retention of the liquid fraction having the opposite chemical hydrophilic or hydrophobic nature, respectively, than the hydrophilic of hydrophobic nature of the aperture surface, respectively. - introducing a system containing immiscible liquids into the first chamber with the hydrophilized or hydrophobized surface of at least the aperture of the first chamber, - introducing a fluid sample into the first chamber; this step can be performed together with the step of introducing the system containing immiscible liquids or subsequently to the step of introducing the system containing immiscible liquids, or prior to the step of introducing the system containing immiscible liquids, - optional step of emulsification and subsequent phase stabilization, - application of pressure force on the system in the first chamber causing the liquid fraction having the same chemical hydrophilic or hydrophobic nature, respectively, as the hydrophilic or hydrophobic nature of the aperture surface, respectively, to pass through the aperture into the next chamber, and causing the retention of the liquid fraction having the opposite chemical hydrophilic or hydrophobic nature, respectively, than the hydrophilic of hydrophobic nature of the aperture surface, respectively.
A fixing anchor for bolted joints adapted to be secured on a support surface, comprising: - a bent and punched sheet metal base configured according to a first longitudinal segment (1.1) having a joining surface (1.4) for joining same to the support surface by welding, a first end flange (1.2) prolonging from one of the ends of the first longitudinal segment (1.1), and a second end flange (1.3) prolonging from the opposite end of the first longitudinal segment (1.1), where both flanges (1.2, 1.3) are arranged transverse to the first longitudinal segment (1.1) and essentially parallel to one another (1.2, 1.3), and where both end flanges (1.2, 1.3) comprise a hole (1.2.1, 1.3.1) such that the line extending between the centers of both holes establishes the longitudinal direction X-X' in which a screw fastener suitable for the anchor extends, - a bent and punched sheet metal compression part configured according to a segment having a cylindrical sector (2.1) where the steering axis thereof is parallel to direction X-X' and said segment having a cylindrical sector (2.1) extends longitudinally from the first end flange (1.2) to the second end flange (1.3); and comprises a force transmission surface (2.2, 2.3) at each longitudinal end of the compression part, where one force transmission surface (2.2) is in contact with the first end flange (1.2) of the base, and the other force transmission surface (2.3) is in contact with the second end flange (1.3) of the base, where the base and the compression part are joined by welding at least between the surfaces of the end flanges (1.2, 1.3) of the base and the force transmission surfaces (2.2, 2.3) of the compression part which are in contact with one another. - a bent and punched sheet metal base configured according to a first longitudinal segment (1.1) having a joining surface (1.4) for joining same to the support surface by welding, a first end flange (1.2) prolonging from one of the ends of the first longitudinal segment (1.1), and a second end flange (1.3) prolonging from the opposite end of the first longitudinal segment (1.1), where both flanges (1.2, 1.3) are arranged transverse to the first longitudinal segment (1.1) and essentially parallel to one another (1.2, 1.3), and where both end flanges (1.2, 1.3) comprise a hole (1.2.1, 1.3.1) such that the line extending between the centers of both holes establishes the longitudinal direction X-X' in which a screw fastener suitable for the anchor extends, - a bent and punched sheet metal compression part configured according to a segment having a cylindrical sector (2.1) where the steering axis thereof is parallel to direction X-X' and said segment having a cylindrical sector (2.1) extends longitudinally from the first end flange (1.2) to the second end flange (1.3); and comprises a force transmission surface (2.2, 2.3) at each longitudinal end of the compression part, where one force transmission surface (2.2) is in contact with the first end flange (1.2) of the base, and the other force transmission surface (2.3) is in contact with the second end flange (1.3) of the base,
An apparatus (408, 408', 508) for accessing a thoracic duct of a patient's body that includes an outlet adjacent a confluence of an internal jugular vein and subclavian vein of the patient's body, the apparatus configured to engage a vessel wall surrounding the outlet without entering the outlet, the apparatus comprising: a tubular member (410, 410', 510) comprising a proximal end, a distal end sized for introduction into a patient's vasculature, and an aspiration lumen (416, 516) extending between the proximal and distal ends; and an expandable sealing member (450, 450', 550) provided on the distal end, said expandable sealing member expandable from a delivery condition sized for introduction into a patient's vasculature to a deployed condition in which the sealing member defines a concave contact surface (456, 456', 556) shaped for engaging the vessel wall surrounding the outlet of the thoracic duct, the sealing member comprising an aspiration port (458, 458', 558) in the contact surface communicating with the aspiration lumen for removing fluid from the thoracic duct through the aspiration port into the aspiration lumen, wherein the sealing member comprises a membrane (452, 452', 552) including the concave contact surface and the aspiration port and a frame (460, 460', 560) supporting the membrane, the frame movable between a collapsed configuration and an expanded configuration for moving the membrane between the delivery and deployed conditions, and wherein the frame comprises a first arm coupled to a first end of the membrane and a second arm coupled to a second end of the membrane, the arms defining a generally "V" shape in the expanded configuration. a tubular member (410, 410', 510) comprising a proximal end, a distal end sized for introduction into a patient's vasculature, and an aspiration lumen (416, 516) extending between the proximal and distal ends; and an expandable sealing member (450, 450', 550) provided on the distal end, said expandable sealing member expandable from a delivery condition sized for introduction into a patient's vasculature to a deployed condition in which the sealing member defines a concave contact surface (456, 456', 556) shaped for engaging the vessel wall surrounding the outlet of the thoracic duct, the sealing member comprising an aspiration port (458, 458', 558) in the contact surface communicating with the aspiration lumen for removing fluid from the thoracic duct through the aspiration port into the aspiration lumen, wherein the sealing member comprises a membrane (452, 452', 552) including the concave contact surface and the aspiration port and a frame (460, 460', 560) supporting the membrane, the frame movable between a collapsed configuration and an expanded configuration for moving the membrane between the delivery and deployed conditions, and wherein the frame comprises a first arm coupled to a first end of the membrane and a second arm coupled to a second end of the membrane, the arms defining a generally "V" shape in the expanded configuration.
A method for improving the kernel productivity of a maize plant, wherein said method comprises overexpressing in said plant an active glutamine synthetase isoenzyme having at least 95% identity with the polypeptide SEQ ID NO: 2.
A therapeutic agent in combination with an agent that is a checkpoint inhibitor for use in a method of treating a glioma or initiating, enhancing, or prolonging an anti-glioma response in a subject in need thereof comprising administering to the subject the therapeutic agent in combination with the agent that is a checkpoint inhibitor, wherein the therapeutic agent is a glioma lysate-pulsed dendritic cell vaccine, and wherein the checkpoint inhibitor is selected from the group consisting of a monoclonal antibody, a humanized antibody and a fully human antibody or a combination thereof and inhibits a checkpoint protein selected from the group consisting of PD-1 and PDL1 or a combination thereof
An article of tableware being a vessel for soaking in fluid and consuming a plurality of a food item being a cookie, said article having a support structure affixed to the underside at an entry end, said article further comprising: a level floor at a scooping end which extends from said scooping end and which is semicircular at said scooping end; a wall which is half-circumferential at said scooping end and bounds said level floor, which continues longitudinally along parallel paths on laterally opposed sides to said entry end, and which defines a rim at its upper edge;and a sloped floor which merges with the edge of said level floor which is not bounded by the wall opposite said scooping end, which sloped floor runs the remaining longitudinal length of the vessel to said entry end, which is bounded on its lateral sides by the laterally opposed sides of said wall, and which is sloped from said level floor to align with said rim at said entry end, wherein the sloped floor is sloped, aligning with the level floor toward the scooping end and aligning with the rim at the entry end, and wherein the level floor, the sloped floor and the wall are merged to form a vessel body which is capable of holding a fluid, and the length to width ratio of said article of tableware is at least two to one. a level floor at a scooping end which extends from said scooping end and which is semicircular at said scooping end; a wall which is half-circumferential at said scooping end and bounds said level floor, which continues longitudinally along parallel paths on laterally opposed sides to said entry end, and which defines a rim at its upper edge;and a sloped floor which merges with the edge of said level floor which is not bounded by the wall opposite said scooping end, which sloped floor runs the remaining longitudinal length of the vessel to said entry end, which is bounded on its lateral sides by the laterally opposed sides of said wall, and which is sloped from said level floor to align with said rim at said entry end, wherein the sloped floor is sloped, aligning with the level floor toward the scooping end and aligning with the rim at the entry end, and wherein the level floor, the sloped floor and the wall are merged to form a vessel body which is capable of holding a fluid, and the length to width ratio of said article of tableware is at least two to one.
A method for automatic configuration of command keys (11, 21, 22) of a device (10, 20) for control of display means including a plurality of screens, each screen being configured to display one or more formats, comprising a step of: - selecting a screen from among said screens of the display means, wherein it comprises the following steps: - determining a set of formats that can be displayed on, and a current display format of, said selected screen; - updating visualization aids associated respectively with said command keys to differentiate said current display format; - assigning to said command keys (11, 21, 22) of the device (10, 20) for control of functions that command the display respectively of formats that are displayable on said selected screen; and - updating said visualization aids to visually identify the formats assigned respectively to said command keys. - selecting a screen from among said screens of the display means, wherein it comprises the following steps: - determining a set of formats that can be displayed on, and a current display format of, said selected screen; - updating visualization aids associated respectively with said command keys to differentiate said current display format; - assigning to said command keys (11, 21, 22) of the device (10, 20) for control of functions that command the display respectively of formats that are displayable on said selected screen; and - updating said visualization aids to visually identify the formats assigned respectively to said command keys.
An electrolyser with at least one electrolysis cell arranged between two end plates (6, 8), in a polymer electrolyte membrane construction manner, and with means for producing a pressing force between the end plates (6, 8), characterised in that the means for producing a pressing force comprise an actuator which via a closed overflow path from the inside of the electrolyser to the actuator is controlled by the gas pressure produced by the electrolysis cell, wherein the actuator comprises a pressure amplifier which produces a pressing pressure exerted onto the electrolysis cell, which is greater than the gas pressure produced by the electrolysis cell.
A composite sintered material comprising: cubic boron nitride grains; and hexagonal boron nitride grains or the hexagonal boron nitride grains and wurtzite type boron nitride grains, wherein a dislocation density of the cubic boron nitride grains is more than or equal to 1×10 15 /m 2 and less than or equal to 1×10 17 /m 2, the dislocation density being measured as described in the description, a median diameter d50 of equivalent circle diameters of the cubic boron nitride grains is more than or equal to 10 nm and less than or equal to 500 nm, the median diameter d50 being measured as described in the description, and a relationship of the following expression 2a is satisfied: 0.05 ≤ Vh + Vw / Vc + Vh + Vw ≤ 0.4, where Vc represents a volume-based content ratio of the cubic boron nitride grains, Vh represents a volume-based content ratio of the hexagonal boron nitride grains, and Vw represents a volume-based content ratio of the wurtzite type boron nitride grains. cubic boron nitride grains; and hexagonal boron nitride grains or the hexagonal boron nitride grains and wurtzite type boron nitride grains, wherein a dislocation density of the cubic boron nitride grains is more than or equal to 1×10 15 /m 2 and less than or equal to 1×10 17 /m 2, the dislocation density being measured as described in the description, a median diameter d50 of equivalent circle diameters of the cubic boron nitride grains is more than or equal to 10 nm and less than or equal to 500 nm, the median diameter d50 being measured as described in the description, and a relationship of the following expression 2a is satisfied: 0.05 ≤ Vh + Vw / Vc + Vh + Vw ≤ 0.4, where Vc represents a volume-based content ratio of the cubic boron nitride grains, Vh represents a volume-based content ratio of the hexagonal boron nitride grains, and Vw represents a volume-based content ratio of the wurtzite type boron nitride grains.
A nucleic acid molecule comprising: (a) a first polynucleotide having at least 95% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO: 2; and (b) a second polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 4; wherein (a) and (b) are joined 5'-3' in this order either contiguously or wherein 1-10 linker nucleotides are present between the first and second polynucleotides, and wherein said nucleic acid molecule is capable of promoting transcription of an operably-linked heterologous polynucleotide in a mammalian cell. (a) a first polynucleotide having at least 95% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO: 2; and (b) a second polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 4;
A method performed by a remote unit, the method comprising: transmitting a request message to one or more network devices; in response to transmitting the request message, authenticating with the one or more network devices; in response to successfully authenticating with the one or more network devices, receiving a security mode command message having a first security key derived with a public land mobile network identity associated with the one or more network devices as input; deriving a second security key with an associated public land mobile network identifier as input; verifying the integrity of the security mode command message is invalid by determining a mismatch between the first security key and the second security key; and in response to the verification of the integrity of the security mode command message indicating invalidity, performing a cell reselection procedure. transmitting a request message to one or more network devices; in response to transmitting the request message, authenticating with the one or more network devices; in response to successfully authenticating with the one or more network devices, receiving a security mode command message having a first security key derived with a public land mobile network identity associated with the one or more network devices as input; deriving a second security key with an associated public land mobile network identifier as input; verifying the integrity of the security mode command message is invalid by determining a mismatch between the first security key and the second security key; and in response to the verification of the integrity of the security mode command message indicating invalidity, performing a cell reselection procedure.
Vehicle tyre with a decorative lateral wall hatching comprising a multiplicity of linearly running elevations which are formed on hatching areas that form hatching elements, wherein the hatching elements are identical regular or irregular n-sided polygons, where n is from four to six, and directly adjoin one another with common outer element sides, wherein the number of elevations is the same in all of the hatching areas and wherein, at common element sides of hatching elements, the elevations from the corresponding hatching areas directly abut one another, characterized in that the elevations in the hatching areas of a hatching element extend radially from a central region of the hatching element to the element sides.
A radiation curable fluid including a vinylether (meth)acrylate monomer; a compound having a sulfonic acid group; and a polymeric dispersant with heterocyclic groups having hetero atoms consisting of one or two nitrogen atoms.
An aqueous coating composition comprising: an anionic acrylic polymer, and from 0.1% to 1.55%, by weight based on the total weight of the aqueous coating composition, of an acetoacetamide functional compound having the structure of formula, where R is hydrogen or a C 1 -C 6 alkyl group; D is a group represented by Structure A; L and M are each independently hydrogen, a C 1 -C 6 alkyl group, or a group represented by Structure A; wherein Structure A has the following structure, where R 1, R 2, and R 3 are each independently hydrogen or methyl; x, y, and z are each independently an average value ranging from 0 to 50; and n is 0 or 1; provided that the sum of x, y, and z in formula is at least 2. an anionic acrylic polymer, and from 0.1% to 1.55%, by weight based on the total weight of the aqueous coating composition, of an acetoacetamide functional compound having the structure of formula, where R is hydrogen or a C 1 -C 6 alkyl group; D is a group represented by Structure A; L and M are each independently hydrogen, a C 1 -C 6 alkyl group, or a group represented by Structure A; wherein Structure A has the following structure, where R 1, R 2, and R 3 are each independently hydrogen or methyl; x, y, and z are each independently an average value ranging from 0 to 50; and n is 0 or 1; provided that the sum of x, y, and z in formula is at least 2.
An isolated human antibody, or an antigen-binding portion thereof, that binds to apical membrane antigen 1 (AMA-1) of Plasmodium parasites, in particular to AMA-1 of Plasmodium falciparum, wherein said antibody or antigen-binding portion thereof inhibits the invasion of a Plasmodium parasite into the erythrocyte and/or the growth of the Plasmodium parasite within the erythrocyte, wherein the isolated antibody or antigen-binding portion thereof is a monoclonal antibody, an antibody from human B-cell cultures, a recombinant antibody, a synthetic antibody or an antigen-binding portion thereof, and wherein said isolated human antibody, or an antigen-binding portion thereof has a light chain variable region (LCVR) comprising CDR1 of SEQ ID NO:1, CDR2 of SEQ ID N0:2 and CDR3 of SEQ ID N0:3, and a heavy chain variable region (HCVR) comprising CDR1 of SEQ ID NO:4, CDR2 of SEQ ID NO:5 and CDR3 of SEQ ID N0:6.