An apparatus for applying surgical clips, the apparatus comprising: a handle portion a housing body portion supported by and extending from the handle portion, the housing body portion housing a stack of clips therein; a pair of jaws (16,18) supported at a distal end of the housing body portion; the housing body portion including: a clip pusher extending into the handle portion wherein the clip pusher is operable to advance a distal-most clip from the stack of clips to a position between the pair of jaws (16,18); a camming member extending into the handle portion, the camming member being operable to approximate the pair of jaws (16,18) to form a clip loaded into the pair of jaws (16,18), the camming member defining at least one notch formed therein for selective engagement with a lockout member; a clip follower disposed proximal of the stack of clips, the clip follower being operable to urge the stack of clips distally toward the pair of jaws (16,18) after a distal-most clip thereof is advanced into the pair of jaws (16,18); a lockout member including an engagement member for retaining the lockout member in a first position in slidable relation to the camming member and at least one stop member (704, 706) for securing the lockable member to a second position, the lockable member being movable from the first position to the second position interlocked with the camming member; wherein in the second position, the at least one stop member (704,706) engages the at least one notch of the camming member to limit a distal movement of the camming member; wherein the clip follower actuates the lockout member to the second position after a final clip of the stack of clips is formed by the pair of jaws (16,18) wherein the lockout engagement member normally engages a stationary surface provided by a separator plate lockout member, and wherein the clip follower has a lockout tab; characterised in that the lockout tab is arranged to be positioned to contact the lockout engagement member when the final clip is discharged from the clip stack; wherein in use, when the final clip is discharged from the clip stack the clip follower moves to bring the lockout tab of the clip follower to directly engage and displace the engagement member from the separator plate lockout member whereby the lockout member is freed for movement from the first position to the second locked out position. a handle portion a housing body portion supported by and extending from the handle portion, the housing body portion housing a stack of clips therein; a pair of jaws (16,18) supported at a distal end of the housing body portion; the housing body portion including: a clip pusher extending into the handle portion wherein the clip pusher is operable to advance a distal-most clip from the stack of clips to a position between the pair of jaws (16,18); a camming member extending into the handle portion, the camming member being operable to approximate the pair of jaws (16,18) to form a clip loaded into the pair of jaws (16,18), the camming member defining at least one notch formed therein for selective engagement with a lockout member; a clip follower disposed proximal of the stack of clips, the clip follower being operable to urge the stack of clips distally toward the pair of jaws (16,18) after a distal-most clip thereof is advanced into the pair of jaws (16,18); a lockout member including an engagement member for retaining the lockout member in a first position in slidable relation to the camming member and at least one stop member (704, 706) for securing the lockable member to a second position, the lockable member being movable from the first position to the second position interlocked with the camming member; wherein in the second position, the at least one stop member (704,706) engages the at least one notch of the camming member to limit a distal movement of the camming member; wherein the clip follower actuates the lockout member to the second position after a final clip of the stack of clips is formed by the pair of jaws (16,18) wherein the lockout engagement member normally engages a stationary surface provided by a separator plate lockout member, and wherein the clip follower has a lockout tab; characterised in that the lockout tab is arranged to be positioned to contact the lockout engagement member when the final clip is discharged from the clip stack; wherein in use, when the final clip is discharged from the clip stack the clip follower moves to bring the lockout tab of the clip follower to directly engage and displace the engagement member from the separator plate lockout member whereby the lockout member is freed for movement from the first position to the second locked out position.