A roller pump comprising: a drive shaft defining a central axis; a motor coupled to the drive shaft for rotating the drive shaft about the central axis; a roller head assembly including: a hub mounted to the drive shaft, a first slide body slidably connected to the hub such that the slide body rotates with rotation of the hub, a first roller rotatably coupled to the slide body opposite the drive shaft; a stator frame forming a raceway having an inner arcuate receiving surface; wherein the stator frame is associated with the roller head assembly to define an occlusion zone between the roller and the receiving surface; and an occlusion adjustment assembly for slidably adjusting a radial position of the roller relative to the receiving surface, the occlusion adjustment assembly including: an actuator knob, an actuating structure connected to the knob, a ground shaft disposed within the drive shaft, the ground shaft supporting the actuator knob relative to the drive shaft, wherein the actuating structure interfaces with the slide body to alter a radial position of the slide body relative to the central axis with rotation of the knob; wherein the drive shaft and the ground shaft are rotationally isolated from one another. a drive shaft defining a central axis; a motor coupled to the drive shaft for rotating the drive shaft about the central axis; a roller head assembly including: a hub mounted to the drive shaft, a first slide body slidably connected to the hub such that the slide body rotates with rotation of the hub, a first roller rotatably coupled to the slide body opposite the drive shaft; a stator frame forming a raceway having an inner arcuate receiving surface; wherein the stator frame is associated with the roller head assembly to define an occlusion zone between the roller and the receiving surface; and an occlusion adjustment assembly for slidably adjusting a radial position of the roller relative to the receiving surface, the occlusion adjustment assembly including: an actuator knob, an actuating structure connected to the knob, a ground shaft disposed within the drive shaft, the ground shaft supporting the actuator knob relative to the drive shaft, wherein the actuating structure interfaces with the slide body to alter a radial position of the slide body relative to the central axis with rotation of the knob; wherein the drive shaft and the ground shaft are rotationally isolated from one another. a hub mounted to the drive shaft, a first slide body slidably connected to the hub such that the slide body rotates with rotation of the hub, a first roller rotatably coupled to the slide body opposite the drive shaft; a stator frame forming a raceway having an inner arcuate receiving surface; wherein the stator frame is associated with the roller head assembly to define an occlusion zone between the roller and the receiving surface; and an occlusion adjustment assembly for slidably adjusting a radial position of the roller relative to the receiving surface, the occlusion adjustment assembly including: an actuator knob, an actuating structure connected to the knob, a ground shaft disposed within the drive shaft, the ground shaft supporting the actuator knob relative to the drive shaft, wherein the actuating structure interfaces with the slide body to alter a radial position of the slide body relative to the central axis with rotation of the knob; wherein the drive shaft and the ground shaft are rotationally isolated from one another. an actuator knob, an actuating structure connected to the knob, a ground shaft disposed within the drive shaft, the ground shaft supporting the actuator knob relative to the drive shaft, wherein the actuating structure interfaces with the slide body to alter a radial position of the slide body relative to the central axis with rotation of the knob; wherein the drive shaft and the ground shaft are rotationally isolated from one another.