A clamp applicable to a tyre of a vehicle wheel and comprising: - a body including a plurality of arms extending radially from a central axis and angularly distributed about the central axis; - a plurality of sliders, each slidably coupled to a respective arm to move radially between a retracted position, where it is at a first distance from the central axis, and an extracted position, where it is at a second distance from the central axis, greater than the first distance, each slider including a side abutment surface, configured to abut against a tread of the tyre; - a single manoeuvring member that is movably connected to the clamp body; - a plurality of connecting levers, each connecting lever having a first end that is articulated to the manoeuvring member and a second end that is articulated to a corresponding slider of the plurality of sliders to allow the sliders to move simultaneously so that a movement of the manoeuvring member in a first direction corresponds to a movement of the sliders towards the retracted position and a movement of the manoeuvring member in a second rotation direction, opposite to the first direction, corresponds to a movement of the sliders towards the extracted position; - a locking device that is movable between a locked position, where it acts on the manoeuvring member to prevent it from moving in the second rotation direction, and an unlocked position, where it allows the manoeuvring member to move in the first and second rotation directions, the clamp being characterized in that it comprises a single handgrip which is integral with said manoeuvring member and configured to be gripped by a user to move the manoeuvring member directly. - a body including a plurality of arms extending radially from a central axis and angularly distributed about the central axis; - a plurality of sliders, each slidably coupled to a respective arm to move radially between a retracted position, where it is at a first distance from the central axis, and an extracted position, where it is at a second distance from the central axis, greater than the first distance, each slider including a side abutment surface, configured to abut against a tread of the tyre; - a single manoeuvring member that is movably connected to the clamp body; - a plurality of connecting levers, each connecting lever having a first end that is articulated to the manoeuvring member and a second end that is articulated to a corresponding slider of the plurality of sliders to allow the sliders to move simultaneously so that a movement of the manoeuvring member in a first direction corresponds to a movement of the sliders towards the retracted position and a movement of the manoeuvring member in a second rotation direction, opposite to the first direction, corresponds to a movement of the sliders towards the extracted position; - a locking device that is movable between a locked position, where it acts on the manoeuvring member to prevent it from moving in the second rotation direction, and an unlocked position, where it allows the manoeuvring member to move in the first and second rotation directions, the clamp being characterized in that it comprises a single handgrip which is integral with said manoeuvring member and configured to be gripped by a user to move the manoeuvring member directly.