A universal wiper base assembly structure for accommodating a wiper driving arm, the universal wiper base assembly structure comprising: a fastening base, comprising a main body and a decorative cover, wherein the main body comprises a coupling hole defined at a bottom thereof, an insertion slot defined at a top thereof, a protruding platform, a positioning protrusion disposed on the protruding platform, a first shaft hole defined at a lateral side thereof, two limiting arc surfaces disposed on two sides thereof opposite to each other, and a plurality of engagement grooves defined on a bottom surface thereof, and the decorative cover is rotatably connected to a front side of the main body and comprises a fastening slot; a rear base, comprising two contact blocks disposed on two sides thereof opposite to each other, a top abutting block abutting against the positioning protrusion, a trench defined in front of the top abutting block, and two hooks disposed in front of the top abutting block, wherein the rear base is detachably coupled to a rear side of the main body through the two hooks being engaged with the main body; a combination base, detachably coupled to a top surface of the main body and positioned in the trench, and comprising two side plates, a connection plate located between the two side plates, and an open groove defined at a position corresponding to the protruding platform and the positioning protrusion, wherein each of the side plates comprises a second shaft hole defined at a position corresponding to the first shaft hole; and an outer cover, comprising a fastening block, an opening exposing the protruding platform and the positioning protrusion, and a third shaft hole defined at a position corresponding the second shaft hole, wherein the outer cover is detachably fixed to the combination base by the fastening block being engaged with the fastening slot; wherein the wiper driving arm is positioned through the rear base, the combination base, or/and the outer cover being selectively coupled to the fastening base. a fastening base, comprising a main body and a decorative cover, wherein the main body comprises a coupling hole defined at a bottom thereof, an insertion slot defined at a top thereof, a protruding platform, a positioning protrusion disposed on the protruding platform, a first shaft hole defined at a lateral side thereof, two limiting arc surfaces disposed on two sides thereof opposite to each other, and a plurality of engagement grooves defined on a bottom surface thereof, and the decorative cover is rotatably connected to a front side of the main body and comprises a fastening slot; a rear base, comprising two contact blocks disposed on two sides thereof opposite to each other, a top abutting block abutting against the positioning protrusion, a trench defined in front of the top abutting block, and two hooks disposed in front of the top abutting block, wherein the rear base is detachably coupled to a rear side of the main body through the two hooks being engaged with the main body; a combination base, detachably coupled to a top surface of the main body and positioned in the trench, and comprising two side plates, a connection plate located between the two side plates, and an open groove defined at a position corresponding to the protruding platform and the positioning protrusion, wherein each of the side plates comprises a second shaft hole defined at a position corresponding to the first shaft hole; and an outer cover, comprising a fastening block, an opening exposing the protruding platform and the positioning protrusion, and a third shaft hole defined at a position corresponding the second shaft hole, wherein the outer cover is detachably fixed to the combination base by the fastening block being engaged with the fastening slot; wherein the wiper driving arm is positioned through the rear base, the combination base, or/and the outer cover being selectively coupled to the fastening base.