A biopsy device, comprising: (a) a body; (b) a needle extending distally relative to the body, wherein the needle defines a first lumen and a second lumen, wherein the first lumen extends along a first longitudinal axis, wherein the second lumen extends along a second longitudinal axis, wherein the needle includes an opening fluidly coupling the first lumen with the second lumen; (c) a cutter, wherein the cutter is configured to translate relative to the needle to sever tissue; and (d) a valve assembly, the valve assembly including: (i) a vent opening, and (ii) a spool body, the spool body including a plurality of cutter engaging members extending inwardly within a hollow interior of the spool body and longitudinally between a proximal end and a distal end of the spool body, the cutter engaging members defining a plurality of vent channels extending through at least a portion of the spool body, the plurality of vent channels being configured to communicate fluid from a proximal end portion of the spool body to a distal end portion of the spool body, wherein the spool body is movable relative to the vent opening between a first position and a second position, the spool body being configured to transition between the first and second position by moving in proportion to translation of the cutter, wherein the valve assembly is configured to couple the second lumen of the needle to the vent opening via at least one vent channel of the plurality of vent channels when the spool body is in the first position, wherein the valve assembly is configured such that the second lumen is sealed relative to the vent opening when the spool body is in the second position. (a) a body; (b) a needle extending distally relative to the body, wherein the needle defines a first lumen and a second lumen, wherein the first lumen extends along a first longitudinal axis, wherein the second lumen extends along a second longitudinal axis, wherein the needle includes an opening fluidly coupling the first lumen with the second lumen; (c) a cutter, wherein the cutter is configured to translate relative to the needle to sever tissue; and (d) a valve assembly, the valve assembly including: (i) a vent opening, and (ii) a spool body, the spool body including a plurality of cutter engaging members extending inwardly within a hollow interior of the spool body and longitudinally between a proximal end and a distal end of the spool body, the cutter engaging members defining a plurality of vent channels extending through at least a portion of the spool body, the plurality of vent channels being configured to communicate fluid from a proximal end portion of the spool body to a distal end portion of the spool body, wherein the spool body is movable relative to the vent opening between a first position and a second position, the spool body being configured to transition between the first and second position by moving in proportion to translation of the cutter, wherein the valve assembly is configured to couple the second lumen of the needle to the vent opening via at least one vent channel of the plurality of vent channels when the spool body is in the first position, wherein the valve assembly is configured such that the second lumen is sealed relative to the vent opening when the spool body is in the second position. (i) a vent opening, and (ii) a spool body, the spool body including a plurality of cutter engaging members extending inwardly within a hollow interior of the spool body and longitudinally between a proximal end and a distal end of the spool body, the cutter engaging members defining a plurality of vent channels extending through at least a portion of the spool body, the plurality of vent channels being configured to communicate fluid from a proximal end portion of the spool body to a distal end portion of the spool body, wherein the spool body is movable relative to the vent opening between a first position and a second position, the spool body being configured to transition between the first and second position by moving in proportion to translation of the cutter, wherein the valve assembly is configured to couple the second lumen of the needle to the vent opening via at least one vent channel of the plurality of vent channels when the spool body is in the first position, wherein the valve assembly is configured such that the second lumen is sealed relative to the vent opening when the spool body is in the second position.