A method for generating an image depicting tissue microvasculature using an ultrasound system, the steps of the method comprising: (a) with an ultrasound imaging system, recording a sequence of first images of a blood vessel of a tissue, said blood vessel having a first spatial scale; (b) transforming the sequence of first images into a second image by separating a weakly-correlated ultrasound data of the sequence of first images from a highly-correlated ultrasound data of the sequence of first images, wherein said separating is carried out based on a pre-determined threshold value, wherein said weakly-correlated ultrasound data represents blood activity, wherein said highly-correlated ultrasound data represents more than 99% of energy in singular values; (c) generating a third image by reducing a spatially-variant background signal corresponding to features having a second spatial scale from the second image using a circular morphology structure, wherein the spatially-variant background signal is reduced by at least 10 dB; (d) transforming the third image into a fourth image by equalizing variations of intensity across the third image to compensate for ultrasound fluctuations caused by relative orientation of a probe of the ultrasound imaging system and the blood vessel; and (e) adjusting visibility of said blood vessel presented for viewing while forming a visually-perceived output, from said ultrasound imaging system, in which the third image has been modified based on representation of said blood vessel as a tubular structure. (a) with an ultrasound imaging system, recording a sequence of first images of a blood vessel of a tissue, said blood vessel having a first spatial scale; (b) transforming the sequence of first images into a second image by separating a weakly-correlated ultrasound data of the sequence of first images from a highly-correlated ultrasound data of the sequence of first images, wherein said separating is carried out based on a pre-determined threshold value, wherein said weakly-correlated ultrasound data represents blood activity, wherein said highly-correlated ultrasound data represents more than 99% of energy in singular values; wherein said separating is carried out based on a pre-determined threshold value, wherein said weakly-correlated ultrasound data represents blood activity, wherein said highly-correlated ultrasound data represents more than 99% of energy in singular values; (c) generating a third image by reducing a spatially-variant background signal corresponding to features having a second spatial scale from the second image using a circular morphology structure, wherein the spatially-variant background signal is reduced by at least 10 dB; (d) transforming the third image into a fourth image by equalizing variations of intensity across the third image to compensate for ultrasound fluctuations caused by relative orientation of a probe of the ultrasound imaging system and the blood vessel; and (e) adjusting visibility of said blood vessel presented for viewing while forming a visually-perceived output, from said ultrasound imaging system, in which the third image has been modified based on representation of said blood vessel as a tubular structure.