A spin column assembly, comprising: a) a spin column device, the spin column device comprising: 1) a column, the column having an inner diameter and an upper opening; and 2) a lower end containing an effluent port, wherein the effluent port comprises an opening to allow passage of effluent liquids; characterized in that the spin column assembly further comprises: b) a monolithic HGR (Height Greater than or equal to the Radius) filter assembly inserted within the spin column device above the lower end of the spin column device, the filter assembly comprising a plurality of cylindrical elements (42, 44), each cylindrical element (42, 44) having a curved outer surface, the cylindrical elements (42, 44) comprising: 1) a separation media element having an upper surface, said separation media element comprised of separation media or fiber impregnated with or coated with separation media, the separation media being selected from the group consisting of cross-linked dextrans, polyacrylamides, cellulose particles, ion exchange resins, silica particles, silica gels, and affinity chromatography media; and 2) a first rigid porous HGR filter element in close contact with the upper surface of the separation media element, the filter element having a diameter about equal to the inner diameter of the column and a height greater than half the inner diameter of the column, said filter element comprised of fiber or sintered material, the fiber selected from the group consisting of cellulose, cellulose acetate, nitrocellulose, polyethylene, nylon and polytetrafluoroethylene (Teflon®), the sintered material selected from the group consisting of plastic, ceramic and metal; wherein the plurality of cylindrical elements (42, 44) are aligned next to each other and held together by a casing that coats the entire curved outer surface of all the aligned cylindrical elements (42, 44), the casing consisting of a cellophane film or polyvinyl chloride film. a) a spin column device, the spin column device comprising: 1) a column, the column having an inner diameter and an upper opening; and 2) a lower end containing an effluent port, wherein the effluent port comprises an opening to allow passage of effluent liquids; 1) a column, the column having an inner diameter and an upper opening; and 2) a lower end containing an effluent port, wherein the effluent port comprises an opening to allow passage of effluent liquids; b) a monolithic HGR (Height Greater than or equal to the Radius) filter assembly inserted within the spin column device above the lower end of the spin column device, the filter assembly comprising a plurality of cylindrical elements (42, 44), each cylindrical element (42, 44) having a curved outer surface, the cylindrical elements (42, 44) comprising: 1) a separation media element having an upper surface, said separation media element comprised of separation media or fiber impregnated with or coated with separation media, the separation media being selected from the group consisting of cross-linked dextrans, polyacrylamides, cellulose particles, ion exchange resins, silica particles, silica gels, and affinity chromatography media; and 2) a first rigid porous HGR filter element in close contact with the upper surface of the separation media element, the filter element having a diameter about equal to the inner diameter of the column and a height greater than half the inner diameter of the column, said filter element comprised of fiber or sintered material, the fiber selected from the group consisting of cellulose, cellulose acetate, nitrocellulose, polyethylene, nylon and polytetrafluoroethylene (Teflon®), the sintered material selected from the group consisting of plastic, ceramic and metal; wherein the plurality of cylindrical elements (42, 44) are aligned next to each other and held together by a casing that coats the entire curved outer surface of all the aligned cylindrical elements (42, 44), the casing consisting of a cellophane film or polyvinyl chloride film. 1) a separation media element having an upper surface, said separation media element comprised of separation media or fiber impregnated with or coated with separation media, the separation media being selected from the group consisting of cross-linked dextrans, polyacrylamides, cellulose particles, ion exchange resins, silica particles, silica gels, and affinity chromatography media; and 2) a first rigid porous HGR filter element in close contact with the upper surface of the separation media element, the filter element having a diameter about equal to the inner diameter of the column and a height greater than half the inner diameter of the column, said filter element comprised of fiber or sintered material, the fiber selected from the group consisting of cellulose, cellulose acetate, nitrocellulose, polyethylene, nylon and polytetrafluoroethylene (Teflon®), the sintered material selected from the group consisting of plastic, ceramic and metal;