A compound of Formula I: wherein R 1 is H; halo; -C 1-6 alkyl; -C 1-6 alkoxy; optionally substituted pyridyl; optionally substituted pyrimidinyl; optionally substituted pyrazinyl; optionally substituted pyrazolyl; optionally substituted imidazolyl; optionally substituted isoxazolyl; optionally substituted oxazolyl; optionally substituted thiazolyl; optionally substituted isothiazolyl; optionally substituted morpholinyl; optionally substituted piperazinyl, optionally substituted piperidinyl; optionally substituted tetrahydropyranyl; optionally substituted pyrrolidinyl; tetrahydrothiopyranyl 1,1-dioxide; thiomorpholinyl 1,1-dioxide; pyrrolidinyl-one; piperidinyl-one; optionally substituted -NH-aryl; optionally substituted -NH-pyridyl; optionally substituted -NH-pyrimidinyl; -C NHC 1-6 alkyl; - C N(C 1-6 alkyl) 2; -NHS 2 C 1-6 alkyl; -N(C 1-6 alkyl)S 2 C 1-6 alkyl; -NHC C 1-6 alkyl; -NC 1-6 alkylC C 1-6 alkyl; -NHC OC 1-6 alkyl; -NC 1-6 alkylC OC 1-6 alkyl; -NHC NHC 1-6 alkyl; -NC 1-6 alkylC N(C 1-6 alkyl) 2; optionally substituted -NHC -piperazinyl; or optionally substituted -NC 1-6 alkylC -piperazinyl; each R 2 is independently H, halo, -C 1-6 alkyl, -C 1-6 alkoxy, -OH, -O-alkaryl, or trihaloalkyl; R 3 is H or halo; A is CR 2 or N; B is CR 2 or N; Q is -S 2 aryl optionally substituted with halo or C 1-6 alkyl; pyridyl optionally substituted with halo or -C NHphenyl; pyrimidinyl; pyrazinyl; -C -NHC -alkaryl optionally substituted with halo or C 1-6 alkyl; -C -NHC -alkaryl optionally substituted with halo or C 1-6 alkyl; -C -alkaryl optionally substituted with halo or C 1-6 alkyl; -C NH-aryl optionally substituted with halo, C 1-6 alkyl or C 1-6 alkoxy; -C -O-aryl optionally substituted with halo, C 1-6 alkyl or C 1-6 alkoxy; or wherein X is CR 6, wherein R 6 is H or C 1-6 alkyl; or N; R 4 is H; C 1-6 alkoxy; halo; -OC 1-6 alkylene-O-C 1-6 alkyl; -NHC 1-6 alkyl; or -N(C 1-6 alkyl) 2; R 5 is aryl optionally substituted with halo or C 1-6 alkyl; or alkaryl optionally substituted with halo or C 1-6 alkyl; or wherein Y is C or N; R 7 is H or C 1-6 alkyl; R 8 is H; C 1-6 alkylene-O-C 1-6 alkyl; C 1-6 alkyl; C 1-6 alkylene-O-C 1-6 alkaryl; or C 1-6 alkylene-OH; R 9 is H, C 1-6 alkyl; or halo; or wherein R 10 is H; halo; or C 1-6 alkyl; or wherein R 11 is H or C 1-6 alkyl; R 12 is H; C 1-6 alkyl; or aryl optionally substituted with halo; R 13 is H; C 1-6 alkyl; or trihaloC 1-6 alkyl; or wherein R 14 is H; C 1-6 alkyl; or halo; or a pharmaceutically acceptable salt thereof. R 1 is H; halo; -C 1-6 alkyl; -C 1-6 alkoxy; optionally substituted pyridyl; optionally substituted pyrimidinyl; optionally substituted pyrazinyl; optionally substituted pyrazolyl; optionally substituted imidazolyl; optionally substituted isoxazolyl; optionally substituted oxazolyl; optionally substituted thiazolyl; optionally substituted isothiazolyl; optionally substituted morpholinyl; optionally substituted piperazinyl, optionally substituted piperidinyl; optionally substituted tetrahydropyranyl; optionally substituted pyrrolidinyl; tetrahydrothiopyranyl 1,1-dioxide; thiomorpholinyl 1,1-dioxide; pyrrolidinyl-one; piperidinyl-one; optionally substituted -NH-aryl; optionally substituted -NH-pyridyl; optionally substituted -NH-pyrimidinyl; -C NHC 1-6 alkyl; - C N(C 1-6 alkyl) 2; -NHS 2 C 1-6 alkyl; -N(C 1-6 alkyl)S 2 C 1-6 alkyl; -NHC C 1-6 alkyl; -NC 1-6 alkylC C 1-6 alkyl; -NHC OC 1-6 alkyl; -NC 1-6 alkylC OC 1-6 alkyl; -NHC NHC 1-6 alkyl; -NC 1-6 alkylC N(C 1-6 alkyl) 2; optionally substituted -NHC -piperazinyl; or optionally substituted -NC 1-6 alkylC -piperazinyl; each R 2 is independently H, halo, -C 1-6 alkyl, -C 1-6 alkoxy, -OH, -O-alkaryl, or trihaloalkyl; R 3 is H or halo; A is CR 2 or N; B is CR 2 or N; Q is -S 2 aryl optionally substituted with halo or C 1-6 alkyl; pyridyl optionally substituted with halo or -C NHphenyl; pyrimidinyl; pyrazinyl; -C -NHC -alkaryl optionally substituted with halo or C 1-6 alkyl; -C -NHC -alkaryl optionally substituted with halo or C 1-6 alkyl; -C -alkaryl optionally substituted with halo or C 1-6 alkyl; -C NH-aryl optionally substituted with halo, C 1-6 alkyl or C 1-6 alkoxy; -C -O-aryl optionally substituted with halo, C 1-6 alkyl or C 1-6 alkoxy; or wherein X is CR 6, wherein R 6 is H or C 1-6 alkyl; or N; R 4 is H; C 1-6 alkoxy; halo; -OC 1-6 alkylene-O-C 1-6 alkyl; -NHC 1-6 alkyl; or -N(C 1-6 alkyl) 2; R 5 is aryl optionally substituted with halo or C 1-6 alkyl; or alkaryl optionally substituted with halo or C 1-6 alkyl; wherein Y is C or N; R 7 is H or C 1-6 alkyl; R 8 is H; C 1-6 alkylene-O-C 1-6 alkyl; C 1-6 alkyl; C 1-6 alkylene-O-C 1-6 alkaryl; or C 1-6 alkylene-OH; R 9 is H, C 1-6 alkyl; or halo; R 11 is H or C 1-6 alkyl; R 12 is H; C 1-6 alkyl; or aryl optionally substituted with halo; R 13 is H; C 1-6 alkyl; or trihaloC 1-6 alkyl;