A delivery device comprising an elongated body with a needle with a lumen at a distal end; a first reservoir for a volume of gas to be delivered through the needle; a second reservoir for an active agent containing composition to be delivered through the needle; a gas flow path from the first reservoir to the needle lumen; a first plunger with a force element configured to pressurise the volume of gas in the first reservoir prior to or simultaneous with contact of the distal end of the device to a tissue surface; a second plunger or a push rod configured to provide a delivery force from the force element to the active agent containing composition; a distal element attached to the distal end of the device configured to seal the needle lumen from delivery of the gas under the delivery force; and a mechanism configured to provide a sequential delivery process for the volume of gas and the active agent containing composition; wherein: the distal element comprises a tissue interface and a distal seal, and the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device; the distal element being penetrated is configured to be slidable on the needle to allow advancement of the needle into tissue; the distal seal being penetrated is configured to open a path for flow or delivery of the gas from the first reservoir through the gas flow path to the distal end of the needle; and the active agent containing composition from the second reservoir is delivered through the needle by the second plunger or push rod and force element after all or a portion of the volume of gas has been delivered through the needle. an elongated body with a needle with a lumen at a distal end; a first reservoir for a volume of gas to be delivered through the needle; a second reservoir for an active agent containing composition to be delivered through the needle; a gas flow path from the first reservoir to the needle lumen; a first plunger with a force element configured to pressurise the volume of gas in the first reservoir prior to or simultaneous with contact of the distal end of the device to a tissue surface; a second plunger or a push rod configured to provide a delivery force from the force element to the active agent containing composition; a distal element attached to the distal end of the device configured to seal the needle lumen from delivery of the gas under the delivery force; and a mechanism configured to provide a sequential delivery process for the volume of gas and the active agent containing composition; wherein: the distal element comprises a tissue interface and a distal seal, and the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device; the distal element being penetrated is configured to be slidable on the needle to allow advancement of the needle into tissue; the distal seal being penetrated is configured to open a path for flow or delivery of the gas from the first reservoir through the gas flow path to the distal end of the needle; and the active agent containing composition from the second reservoir is delivered through the needle by the second plunger or push rod and force element after all or a portion of the volume of gas has been delivered through the needle. the distal element comprises a tissue interface and a distal seal, and the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device; the distal element being penetrated is configured to be slidable on the needle to allow advancement of the needle into tissue; the distal seal being penetrated is configured to open a path for flow or delivery of the gas from the first reservoir through the gas flow path to the distal end of the needle; and the active agent containing composition from the second reservoir is delivered through the needle by the second plunger or push rod and force element after all or a portion of the volume of gas has been delivered through the needle.