A compound of Formula or pharmaceutically acceptable salts and stereoisomers thereof, wherein: A 1, A 2, A 3, A 4, and A 5 are independently selected from the group consisting of CH, CR 1 and N; Y is absent or is selected from CH 2 or CHC 1 -C 5 alkyl; is a single bond when Y is CH 2 or CHC 1 -C 5 alkyl; Z 1 and Z 2 are independently selected from the group consisting of CH and N; R 1 is independently selected from the group consisting of halogen, CN, OH, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 2 is selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkylene-OR 4a, C 1 -C 6 alkylene-N(R 4a)(R 4b), C 1 -C 6 alkylene-C N(R 4a)(R 4b), C 1 -C 6 alkylene-C OR 4a, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, and C 3 -C 5 cycloalkyl; R 3 is selected from the group consisting of H, C 1 -C 6 alkyl, and C 1 -C 6 alkylene-C N(R 4a)(R 4b) when Y is absent or, R 3 is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkylene-C N(R 4a)(R 4b) when Y is CH 2 or CHC 1 -C 5 alkyl; R 4a and R 4b are independently selected from H, C 1 -C 4 alkyl, and cyclopropyl; R 5 is selected from the group consisting of H, F, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 6 is selected from the group consisting of H, F, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 7 is selected from the group consisting of H, halogen, CN, OH, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyloxy, O(CH 2) m O(CH 2) n CH 3, O(CH 2) m N(R 4a)(R 4b), OSO 2 CH 3, SO 2 C 1 -C 6 alkyl, C 1 -C 6 alkylene-SO 2 C 1 -C 6 alkyl, SO 2 C 3 -C 6 cycloalkyl, C 1 -C 6 alkylene-SO 2 C 3 -C 6 cycloalkyl, SC 1 -C 6 alkyl, SC 3 -C 6 cycloalkyl, C 1 -C 6 alkylene-SC 1 -C 6 alkyl, C 1 -C 6 alkylene-SC 3 -C 6 cycloalkyl, and S (NR 8a)(R 8b); R 8a is selected from H, C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl; R 8b is C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl; m is an integer selected from the group consisting of 1, 2, and 3; n is an integer selected from the group consisting of 0,1, and 2; with the proviso that R5, R6, and R7 cannot be H simultaneously; and with the proviso the compound is not: and A 1, A 2, A 3, A 4, and A 5 are independently selected from the group consisting of CH, CR 1 and N; Y is absent or is selected from CH 2 or CHC 1 -C 5 alkyl; is a single bond when Y is CH 2 or CHC 1 -C 5 alkyl; Z 1 and Z 2 are independently selected from the group consisting of CH and N; R 1 is independently selected from the group consisting of halogen, CN, OH, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 2 is selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkylene-OR 4a, C 1 -C 6 alkylene-N(R 4a)(R 4b), C 1 -C 6 alkylene-C N(R 4a)(R 4b), C 1 -C 6 alkylene-C OR 4a, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, and C 3 -C 5 cycloalkyl; R 3 is selected from the group consisting of H, C 1 -C 6 alkyl, and C 1 -C 6 alkylene-C N(R 4a)(R 4b) when Y is absent or, R 3 is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkylene-C N(R 4a)(R 4b) when Y is CH 2 or CHC 1 -C 5 alkyl; R 4a and R 4b are independently selected from H, C 1 -C 4 alkyl, and cyclopropyl; R 5 is selected from the group consisting of H, F, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 6 is selected from the group consisting of H, F, C 1 -C 6 alkyl, C 1 -C 3 alkylene-C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl, and C 1 -C 6 alkyloxy; R 7 is selected from the group consisting of H, halogen, CN, OH, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyloxy, O(CH 2) m O(CH 2) n CH 3, O(CH 2) m N(R 4a)(R 4b), OSO 2 CH 3, SO 2 C 1 -C 6 alkyl, C 1 -C 6 alkylene-SO 2 C 1 -C 6 alkyl, SO 2 C 3 -C 6 cycloalkyl, C 1 -C 6 alkylene-SO 2 C 3 -C 6 cycloalkyl, SC 1 -C 6 alkyl, SC 3 -C 6 cycloalkyl, C 1 -C 6 alkylene-SC 1 -C 6 alkyl, C 1 -C 6 alkylene-SC 3 -C 6 cycloalkyl, and S (NR 8a)(R 8b); R 8a is selected from H, C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl; R 8b is C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl; m is an integer selected from the group consisting of 1, 2, and 3; n is an integer selected from the group consisting of 0,1, and 2; with the proviso that R5, R6, and R7 cannot be H simultaneously; and with the proviso the compound is not: and