A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein: G 1 is selected from: Z 1 is -C 1 -C 3 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; Z 2 is -O-, -S-, -S(O 2)-, -NH-, -N(G 6)-, -N(C G 6)-, -N(SO 2 G 6)-, -CH(G 4)-, -C(G 6)(G 4)-,-C -, -C(-C s -C 6 alkylene-)-, -C(-O(C s -C 5 alkylene)-), -C(-(C 1 -C 3 alkylene)-O-(C 1 -C 2 alkylene)-)-, -C(-(C 1 -C 3 alkylene)-NH-(C 1 -C 2 alkylene)-)-, or -C(-(C 1 -C 3 alkylene)-N(G 6)-(C 1 -C 2 alkylene)-)-; Z 3 is -C 1 -C 3 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; Z 4 is -C =C -, -N S(O 2)-, or -N(G 6)S(O 2)-; Z 5 is -C 1 -C 2 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; X is Z 2 or Z 4; G 2 is hydrogen or C 1 -C 3 alkyl; G 3 is -CH(G 6)G 7, -C(CH 3)(G 6)G 7, C 4 -C 6 alkyl, or C 1 -C 3 alkyl where C 1 -C 3 alkyl is substituted with 1-3 fluorines; G 4 is hydrogen F, OH, CN, -PO(OG 6) 2, -SO 3 H, -S(O 2)N(G 6) 2, -S(O 2)G 6, -OG 6, G 6, -C 3 -C 6 cycloalkyl optionally substituted with 1-2 fluorines, CH 2 OH, CH 2 OG 6, G 7, or OG 7; G 5 is hydrogen or C 1 -C 3 alkyl, or G 3; G 6 is C 1 -C 4 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-2 fluorines; G 7 is phenyl; R 3 is hydrogen, Cl, F, CH 3 or OCH 3; R 4 is hydrogen, C 1 -C 3 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-3 fluorines; R 5 is C 1 -C 6 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-3 fluorines A 1 is selected from: wherein R 9 and R 10 are independently selected from H, -CH 3, -CH 2 F, -CHF 2, -CF 3, isopropyl, cyclopropyl, or -CF 2 CH 3; A 2 is H or -CH 3; E 1, E 2 and E 3 are independently selected from H, F, Cl, -CN, -OCH 3, -CH 3, -CH 2 F, -CHF 2, - CF 3; X 1, X 2, and X 3 are independently selected from H, F, Cl, -CN, -OCH 3, -CH 3, -CH 2 F, -CHF 2,-CF 3. G 1 is selected from: Z 1 is -C 1 -C 3 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; Z 2 is -O-, -S-, -S(O 2)-, -NH-, -N(G 6)-, -N(C G 6)-, -N(SO 2 G 6)-, -CH(G 4)-, -C(G 6)(G 4)-,-C -, -C(-C s -C 6 alkylene-)-, -C(-O(C s -C 5 alkylene)-), -C(-(C 1 -C 3 alkylene)-O-(C 1 -C 2 alkylene)-)-, -C(-(C 1 -C 3 alkylene)-NH-(C 1 -C 2 alkylene)-)-, or -C(-(C 1 -C 3 alkylene)-N(G 6)-(C 1 -C 2 alkylene)-)-; Z 3 is -C 1 -C 3 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; Z 4 is -C =C -, -N S(O 2)-, or -N(G 6)S(O 2)-; Z 5 is -C 1 -C 2 alkylene optionally substituted once with G 4 and also optionally substituted once with -CH 3; X is Z 2 or Z 4; G 2 is hydrogen or C 1 -C 3 alkyl; G 3 is -CH(G 6)G 7, -C(CH 3)(G 6)G 7, C 4 -C 6 alkyl, or C 1 -C 3 alkyl where C 1 -C 3 alkyl is substituted with 1-3 fluorines; G 4 is hydrogen F, OH, CN, -PO(OG 6) 2, -SO 3 H, -S(O 2)N(G 6) 2, -S(O 2)G 6, -OG 6, G 6, -C 3 -C 6 cycloalkyl optionally substituted with 1-2 fluorines, CH 2 OH, CH 2 OG 6, G 7, or OG 7; G 5 is hydrogen or C 1 -C 3 alkyl, or G 3; G 6 is C 1 -C 4 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-2 fluorines; G 7 is phenyl; R 3 is hydrogen, Cl, F, CH 3 or OCH 3; R 4 is hydrogen, C 1 -C 3 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-3 fluorines; R 5 is C 1 -C 6 alkyl optionally substituted with 1-3 fluorines, or C 3 -C 6 cycloalkyl optionally substituted with 1-3 fluorines A 1 is selected from: wherein R 9 and R 10 are independently selected from H, -CH 3, -CH 2 F, -CHF 2, -CF 3, isopropyl, cyclopropyl, or -CF 2 CH 3; A 2 is H or -CH 3; E 1, E 2 and E 3 are independently selected from H, F, Cl, -CN, -OCH 3, -CH 3, -CH 2 F, -CHF 2, - CF 3; X 1, X 2, and X 3 are independently selected from H, F, Cl, -CN, -OCH 3, -CH 3, -CH 2 F, -CHF 2,-CF 3.