A compound of Formula III or a tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof, wherein A 4 is CR 4 or N; A 5 is CR 5 or N; A 6 is CR 6 or N; A 8 is CR 8 or N, provided that no more than two of A 4, A 5, A 6 and A 8 is N; each of R a and R b, independently, is H, F, CH 3, CH 2 F, CHF 2 or CF 3; each of R 1 and R 2, independently, is H, F, CH 3, CH 2 F, CHF 2 or CF 3; R 3 is CH 3, CF 3, CH 2 F or CHF 2; each of R 4, R 5, R 6 and R 8, independently, is H, F, Cl or CH 3; R 7 is -NH-C(=O)-R 9, or R 7 is wherein V is NR 10, O or S; and each W, independently, is CH, CF, CCl, CCH 3 or N; R 9 is a ring selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, pyrazolo[3,4-c]pyridinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl or thienyl, wherein the ring is optionally substituted with 1-5 substituents of R 10; and each R 10, independently, is H, halo, haloalkyl, CN, OH, NO 2, NH 2, SF 5, acetyl, -C NHCH 3, oxo, cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl,, piperazinyl, oxetan-3-yl, imidazo-pyridinyl or dioxolyl, wherein each of the cyclopropylmethoxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetan-3-yl or dioxolyl, is optionally substituted independently with 1-5 substituents of F, Cl, CN, NO 2, NH 2, OH, oxo, CF 3, CHF 2, CH 2 F, methyl, methoxy, ethyl, ethoxy, CH 2 CF 3, CH 2 CHF 2, propyl, propoxy, isopropyl, isopropoxy, cyclopropyl, butyl, butoxyl, cyclobutyl, isobutoxy, tert-butoxy, isobutyl, sec-butyl, tert-butyl, cyclopentyl, cyclohexyl, C 1-3 alkylamino-, C 1-3 dialkylamino, C 1-3 thioalkoxyl tetrahydropyranyl, pyrrolidinyl, oxazolyl, thiazolyl or oxetan-3yl. provided that in cases where R 10 is 2-propynyloxy or is substituted with oxazolyl or thiazolyl, then R 7 is -NH-C(=O)-R 9 wherein R 9 is A 4 is CR 4 or N; A 5 is CR 5 or N; A 6 is CR 6 or N; A 8 is CR 8 or N, provided that no more than two of A 4, A 5, A 6 and A 8 is N; each of R a and R b, independently, is H, F, CH 3, CH 2 F, CHF 2 or CF 3; each of R 1 and R 2, independently, is H, F, CH 3, CH 2 F, CHF 2 or CF 3; R 3 is CH 3, CF 3, CH 2 F or CHF 2; each of R 4, R 5, R 6 and R 8, independently, is H, F, Cl or CH 3; R 7 is -NH-C(=O)-R 9, or R 7 is wherein V is NR 10, O or S; and each W, independently, is CH, CF, CCl, CCH 3 or N; wherein V is NR 10, O or S; and each W, independently, is CH, CF, CCl, CCH 3 or N; R 9 is a ring selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, pyrazolo[3,4-c]pyridinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl or thienyl, wherein the ring is optionally substituted with 1-5 substituents of R 10; and each R 10, independently, is H, halo, haloalkyl, CN, OH, NO 2, NH 2, SF 5, acetyl, -C NHCH 3, oxo, cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl,, piperazinyl, oxetan-3-yl, imidazo-pyridinyl or dioxolyl, wherein each of the cyclopropylmethoxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetan-3-yl or dioxolyl, is optionally substituted independently with 1-5 substituents of F, Cl, CN, NO 2, NH 2, OH, oxo, CF 3, CHF 2, CH 2 F, methyl, methoxy, ethyl, ethoxy, CH 2 CF 3, CH 2 CHF 2, propyl, propoxy, isopropyl, isopropoxy, cyclopropyl, butyl, butoxyl, cyclobutyl, isobutoxy, tert-butoxy, isobutyl, sec-butyl, tert-butyl, cyclopentyl, cyclohexyl, C 1-3 alkylamino-, C 1-3 dialkylamino, C 1-3 thioalkoxyl tetrahydropyranyl, pyrrolidinyl, oxazolyl, thiazolyl or oxetan-3yl. provided that in cases where R 10 is 2-propynyloxy or is substituted with oxazolyl or thiazolyl, then R 7 is -NH-C(=O)-R 9 wherein R 9 is