Solid oral pharmaceutical form with modified release of at least one active ingredient, containing at least microparticles containing said active ingredient and at least one viscosifying agent in a form isolated from said microparticles of active ingredient, characterized in that - said microparticles of active ingredient possess an average diameter ranging from 100 to 600 μm, and are formed by a core containing at least said active ingredient and coated with at least one coating layer, - said core is formed by a support particle covered by a layer comprising at least said active ingredient, - said coating layer is formed by a material composed of at least: - 25 to 70 % by weight relative to the total weight of said coating, of at least one water-insoluble polymer A which, - 30 to 75 % by weight relative to the total weight of said coating, of at least one polymer B which is insoluble in water below pH 5 and soluble in water above pH 7, and - 0 to 25 % by weight relative to the total weight of said coating, of at least one plasticizer, - said polymers A and B being in a polymer(s) B/ polymer(s) A weight ratio comprised between 0.75 and 4, and - said coating layer represents at least 35 % by weight, relative to the total weight of said microparticle - said microparticles of active ingredient have an in vitro release profile characterized by: - in an aqueous acid medium with a pH less than 4, a latency period of less than 12 hours, in particular between 0.5 and 8 hours, or even between 1 and 5 hours, followed by the sustained release of the active ingredient, - after increasing pH to a pH greater than 7, an acceleration of the release of the active ingredient. - said microparticles of active ingredient possess an average diameter ranging from 100 to 600 μm, and are formed by a core containing at least said active ingredient and coated with at least one coating layer, - said core is formed by a support particle covered by a layer comprising at least said active ingredient, - said coating layer is formed by a material composed of at least: - 25 to 70 % by weight relative to the total weight of said coating, of at least one water-insoluble polymer A which, - 30 to 75 % by weight relative to the total weight of said coating, of at least one polymer B which is insoluble in water below pH 5 and soluble in water above pH 7, and - 0 to 25 % by weight relative to the total weight of said coating, of at least one plasticizer, - 25 to 70 % by weight relative to the total weight of said coating, of at least one water-insoluble polymer A which, - 30 to 75 % by weight relative to the total weight of said coating, of at least one polymer B which is insoluble in water below pH 5 and soluble in water above pH 7, and - 0 to 25 % by weight relative to the total weight of said coating, of at least one plasticizer, - said polymers A and B being in a polymer(s) B/ polymer(s) A weight ratio comprised between 0.75 and 4, and - said coating layer represents at least 35 % by weight, relative to the total weight of said microparticle - said microparticles of active ingredient have an in vitro release profile characterized by: - in an aqueous acid medium with a pH less than 4, a latency period of less than 12 hours, in particular between 0.5 and 8 hours, or even between 1 and 5 hours, followed by the sustained release of the active ingredient, - after increasing pH to a pH greater than 7, an acceleration of the release of the active ingredient. - in an aqueous acid medium with a pH less than 4, a latency period of less than 12 hours, in particular between 0.5 and 8 hours, or even between 1 and 5 hours, followed by the sustained release of the active ingredient, - after increasing pH to a pH greater than 7, an acceleration of the release of the active ingredient.