mhurhangee/ep-ind-claims huggingface dataset:
A Ral GTPase inhibiting compound for use in treating, ameliorating cancer or preventing metastasis of a cancer in an individual wherein the compound is at least one compound selected from the group consisting of: (6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3- c]pyrazole-5-carbonitrile); (11-(2-chlorophenyl)-10-pentanoyl-2,3,4,5,10,11-hexahydro-1 H -dibenzo[ b, e][1,4]diazepin-1-one); (6-amino-4-(3,5-dichloro-2-hydroxyphenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile); (2-(6-(4-ethylphenyl)-2-p-tolyl-2,3,4,5-tetrahydropyrimidin-4-yl)phenol); (2-(2-(2-methoxyphenyl)-6-(4-methoxyphenyl)-2,3,4,5-tetrahydropyrimidin-4-yl)phenol), and pharmaceutically acceptable enantiomers, diastereomers, racemates, and salts thereof, or wherein the compound is at least one compound selected from the group consisting of: and pharmaceutically acceptable enantiomers, diastereomers, racemates, and salts thereof or wherein the compound has the structure: and pharmaceutically acceptable enantiomers, diastereomers, racemates, and salts thereof, wherein: n = 0 - 5; A is CH 2, NH, or N-oxide; B, M, and D are individually selected from C, N, or N-oxide; R 1, R 2, R 8, R 9, R 11, R 12, R 13 are independently (including when B, M or D are carbon) selected from hydrogen, halogen, -OH, -O-R 14, C 1 -C 24 alkyl, C 3 -C 24 alkenyl, C 4 -C 24 dienyl, C 6 -C 24 trienyl, C 8 -C 24 tetraenyl, C 6 -C 18 aryl, substituted C 6 -C 18 aryl, C 1 -C 14 -alkoxy, carboxy, cyano, C 1 -C 14 alkanoyloxy, C 1 -C 14 alkylthio, C 1 -C 14 alkylsulfonyl, C 2 -C 14 alkoxycarbonyl, C 2 -C 14 alkanoylamino, S-R 14, -SO 2 -R 12, -NHSO 2 R 14 and -NHCO 2 R 14; and, R 14 is phenyl or naphthyl substituted with one to three groups selected from C 1 -C 6 -alkyl, C6-C 10 aryl, C 1 -C 6 alkoxy and halogen, and C 4 -C 20 hydroxyheteroaryl wherein the heteroatoms are selected from the sulfur, nitrogen, and oxygen. n = 0 - 5; A is CH 2, NH, or N-oxide; B, M, and D are individually selected from C, N, or N-oxide; R 1, R 2, R 8, R 9, R 11, R 12, R 13 are independently (including when B, M or D are carbon) selected from hydrogen, halogen, -OH, -O-R 14, C 1 -C 24 alkyl, C 3 -C 24 alkenyl, C 4 -C 24 dienyl, C 6 -C 24 trienyl, C 8 -C 24 tetraenyl, C 6 -C 18 aryl, substituted C 6 -C 18 aryl, C 1 -C 14 -alkoxy, carboxy, cyano, C 1 -C 14 alkanoyloxy, C 1 -C 14 alkylthio, C 1 -C 14 alkylsulfonyl, C 2 -C 14 alkoxycarbonyl, C 2 -C 14 alkanoylamino, S-R 14, -SO 2 -R 12, -NHSO 2 R 14 and -NHCO 2 R 14; and, R 14 is phenyl or naphthyl substituted with one to three groups selected from C 1 -C 6 -alkyl, C6-C 10 aryl, C 1 -C 6 alkoxy and halogen, and C 4 -C 20 hydroxyheteroaryl wherein the heteroatoms are selected from the sulfur, nitrogen, and oxygen.
Thread feeder for textile machines, comprising a support, which comprises at least one clamp for securing the thread feeder onto the textile machine, an upper leg and a lower leg, wherein between the upper and the lower leg (7, 8) an intermediate space is formed, with a shaft which extends when in use vertically through the intermediate space and the legs (7, 8) and is mounted rotatably on the latter, with at least one belt disc, which is arranged on the shaft within the intermediate space and comprises a belt bearing surface for a drive belt, with a clutch, which is configured to couple the at least one belt disc in a non-rotatable manner to the shaft or to release the rotary connection and which comprises a grip for engaging and disengaging, with a thread feeder wheel which is arranged on a lower end of the shaft when in use, in order to be driven by the shaft, with a thread inlet guiding device, which is arranged on the upper leg, wherein underneath the thread inlet guiding device there is free access to the belt disc and the grip of the clutch, characterised in that the grip is arranged adjacent to the belt disc in the intermediate space between the legs (7, 8).
Method for braking a self-propelling road finisher or feeding appliance, wherein at least one wheel of a wheeled undercarriage or a chain of a chain running gear unit can be braked by at least one braking device, having at least one activation means (11, 13), of a brake system, and the at least one braking device is controlled by electrical signals, characterized in that an activation travel path of the activation means is sensed by at least one Sensor, and the activation travel path is divided into a first activation travel path and a subsequent second activation travel path, wherein electrical signals which are separated along the first activation travel path and along the second activation travel path and are proportional to the travel path are generated by sensors (27, 28).
A rubber compound production method comprising a first mixing step wherein at least one cross-linkable unsaturated-chain polymer base, silica, and a silane bonding agent in the alkoxymercaptoalkyl-silane class are mixed together; and a following mixing step wherein a curing system comprising at least sulphur and accelerants is added and mixed to the compound being produced; said method being characterized in that 0.2 to 5 phr of an accelerant, and 0.5 to 6 phr of a zinc salt of a fatty acid with a carbon atom number of C8 to C24 are added at said first mixing step; said accelerant being comprised in the group of benzothiazyl-cyclohexyl-sulphenamide, benzothiazole disulphide (MBTS), N-tert-butyl-2-benzothiazylsulphenamide (TBBS), 2- mercaptobenzothiazole, zinc salts of 2-mercaptobenzothiazole (ZMBT), benzothiazyl-2-dicyalohexyl-sulphenamide (DCBS), diphenylguanidine, triphenylguanidine, diorthotolyl guanidine (DOTG), o-tolylbiguanidine (OTBG), ethylene thiourea and their mixtures.
A method comprising: a) providing a sample previously obtained from a first subject; b) contacting said sample with an agent in a reaction mixture; c) obtaining an enumeration of the abundance of at least 60 microbial taxa in said reaction mixture after contacting said sample with said agent; wherein said method further comprises evaluating said sample by performing a barrier function assay, a cytokine assay and/or an immune response assay after said sample is contacted with the agent, and wherein said first subject is a mammal. a) providing a sample previously obtained from a first subject; b) contacting said sample with an agent in a reaction mixture; c) obtaining an enumeration of the abundance of at least 60 microbial taxa in said reaction mixture after contacting said sample with said agent;
Air-conditioning system comprising a heat exchanger and at least one fan system (46, 48) having an intake side and a discharge side, where - the heat exchanger is at least a section of a wall limiting a first room to be cooled from a second room, - the second room is flow-connected via the fan system (46, 48) to a double floor limiting at least the first room, preferably both the first and the second room, and having a cavity, - a plurality of cold aisles (28, 30) extends on the double floor and are limited by heat-generating units such as computers arranged in racks (38, 40, 42, 44), - the cold aisles are limited by hot aisles (32, 34, 36), and - the cold aisles are connected via through-holes such as slotted panels (24, 26) to the cavity for supplying air-conditioned air into the cold aisles, wherein the hot aisles (32, 34, 36) are areas of the first room, the cold aisles (28, 30) are closed at the top with covers, at least one fan system (46, 48) arranged in the hollow floor of the double floor directly underneath the cold aisle is associated with each cold aisle (28, 30), the at least one fan system is controllable depending on the thermal load of the heat-generating units limiting the cold aisle, and regardless of the thermal loads of the heat-generating units limiting the cold aisles (28, 30) supply air of a constant temperature is applied to the second room, and hence the temperature at the intake side of each fan system is identical. - the heat exchanger is at least a section of a wall limiting a first room to be cooled from a second room, - the second room is flow-connected via the fan system (46, 48) to a double floor limiting at least the first room, preferably both the first and the second room, and having a cavity, - a plurality of cold aisles (28, 30) extends on the double floor and are limited by heat-generating units such as computers arranged in racks (38, 40, 42, 44), - the cold aisles are limited by hot aisles (32, 34, 36), and - the cold aisles are connected via through-holes such as slotted panels (24, 26) to the cavity for supplying air-conditioned air into the cold aisles,
Pneumatic vehicle tyre with a profiled tread, which is divided by a central circumferential groove that is made to the maximum profile depth and by two shoulder-side circumferential grooves that are likewise made to the maximum profile depth into two rows of shoulder blocks and two middle rows of blocks, wherein the rows of shoulder blocks are divided into blocks, wherein successive blocks in the circumferential direction are separated from one another by two transverse grooves (9, 10) that are spaced apart from one another in the circumferential direction and an additional groove that connects these transverse grooves and extends in the circumferential direction approximately in the middle of the row of blocks, wherein the one transverse groove in each case merges into the shoulder-side circumferential groove and the other extends from the additional groove over the edge of the tread, wherein the additional grooves in each case adjoin the end on the inner side of the row of blocks of the transverse grooves merging into the shoulder-side circumferential groove and wherein a base elevation, which has a depth (t 6) that corresponds to the depth (t 6) of the additional grooves, is in each case formed at the end portions on the inner side of the row of blocks of these transverse grooves, characterized in that the transverse grooves merging into the shoulder-side circumferential groove have a depth of 70% to 90% of the profile depth and have a width that increases over their course from the merging regions in the direction of the outer side of the tread, wherein the additional grooves have a depth (t 6) of 1.5 mm to 2.5 mm and a width that decreases over their course from their adjoining regions with the transverse grooves.
A device comprising: a breakable capillary tube configured to absorb and retain a sample of a first liquid by capillary action when placed in contact with the first liquid, the breakable capillary tube having a generally hollow tubular body that is open on one or both ends; a container able to retain the sample of the first liquid as well as a second liquid; an insertion device, the breakable capillary tube being affixed to the insertion device; a force assisted sample ejection mechanism, the force assisted sample ejection mechanism configured to release at least part of the sample of the first liquid from the breakable capillary tube when the sample of the first liquid is retained in the breakable capillary tube, break the breakable capillary tube into at least two pieces in order to release the first liquid; characterized in that, when the insertion device is placed in the container the breakable capillary tube is placed in a test position, wherein the force assisted sample ejection mechanism breaks the breakable capillary tube once the breakable capillary tube is in the test position. a breakable capillary tube configured to absorb and retain a sample of a first liquid by capillary action when placed in contact with the first liquid, the breakable capillary tube having a generally hollow tubular body that is open on one or both ends; a container able to retain the sample of the first liquid as well as a second liquid; an insertion device, the breakable capillary tube being affixed to the insertion device; a force assisted sample ejection mechanism, the force assisted sample ejection mechanism configured to release at least part of the sample of the first liquid from the breakable capillary tube when the sample of the first liquid is retained in the breakable capillary tube, break the breakable capillary tube into at least two pieces in order to release the first liquid; release at least part of the sample of the first liquid from the breakable capillary tube when the sample of the first liquid is retained in the breakable capillary tube, break the breakable capillary tube into at least two pieces in order to release the first liquid; characterized in that, when the insertion device is placed in the container the breakable capillary tube is placed in a test position, wherein the force assisted sample ejection mechanism breaks the breakable capillary tube once the breakable capillary tube is in the test position.
A splint, comprising: a plurality of flexible tubes formed of a first material, wherein the plurality of flexible tubes are coupled together to form a web; a second material positioned in the flexible tubes; characterised by the second material having a lower thermal softening point than the first material; wherein: the web is conformable when the second material is heated to a temperature above the thermal softening point of the second material; and the web is rigid when a temperature of the second material is below the thermal softening point of the second material. a plurality of flexible tubes formed of a first material, wherein the plurality of flexible tubes are coupled together to form a web; a second material positioned in the flexible tubes; characterised by the second material having a lower thermal softening point than the first material; wherein: the web is conformable when the second material is heated to a temperature above the thermal softening point of the second material; and the web is rigid when a temperature of the second material is below the thermal softening point of the second material. the web is conformable when the second material is heated to a temperature above the thermal softening point of the second material; and the web is rigid when a temperature of the second material is below the thermal softening point of the second material.
An electronic device, comprising: a housing, wherein the housing is provided with an opening; a functional module, wherein the functional module is retractable into the housing or extendable out of the housing through the opening; and a driving mechanism, wherein the driving mechanism is arranged in the housing, and the driving mechanism comprises a driving source, a lead screw, a nut set, and a caliper; the driving source is drivingly connected to the lead screw; the nut set comprises a fitting part, and the fitting part is threadedly fitted with the lead screw; a first end of the caliper is in position-limiting fit with the fitting part, and a second end of the caliper is fixedly connected to the functional module; and the cross-sectional shape of the fitting part is a polygon; characterised by, that the nut set further comprises an elastic member and a movable baffle; the movable baffle is connected to the fitting part through the elastic member, and the movable baffle is located on a side of the fitting part away from the opening; the caliper is slidable relative to the fitting part, and the caliper moves along the lead screw; in a case that the caliper is at least partially separated from the fitting part, the elastic member drives the movable baffle to make the caliper be in contact with the fitting part. a housing, wherein the housing is provided with an opening; a functional module, wherein the functional module is retractable into the housing or extendable out of the housing through the opening; and a driving mechanism, wherein the driving mechanism is arranged in the housing, and the driving mechanism comprises a driving source, a lead screw, a nut set, and a caliper; the driving source is drivingly connected to the lead screw; the nut set comprises a fitting part, and the fitting part is threadedly fitted with the lead screw; a first end of the caliper is in position-limiting fit with the fitting part, and a second end of the caliper is fixedly connected to the functional module; and the cross-sectional shape of the fitting part is a polygon; characterised by, that the nut set further comprises an elastic member and a movable baffle; the movable baffle is connected to the fitting part through the elastic member, and the movable baffle is located on a side of the fitting part away from the opening; the caliper is slidable relative to the fitting part, and the caliper moves along the lead screw; in a case that the caliper is at least partially separated from the fitting part, the elastic member drives the movable baffle to make the caliper be in contact with the fitting part.
A method for manufacturing coated paperboard suitable for packaging paperboard applications, the method comprising - coating a first surface of the paperboard web by applying a. a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web, weight of the precoating layer being less than 30 g/m 2, and b. a second coating composition in form of an aqueous polymer dispersion in a curtain coating unit for forming at least one barrier coating layer having a weight less than 20 g/m 2 on top of the precoating layer, and c. a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer, having a weight less than 20 g/m 2, on top of the barrier coating layer, whereby the second and third coating layers are applied simultaneously as aqueous dispersions without intermediate drying between the coating layers, - controlling and adjusting the temperature of the coated paperboard web in a adjustable heating unit, which is configured to control and adjust the temperature of the paperboard web and to remove water therefrom, and - cooling the paperboard web in at least one cooling unit. - coating a first surface of the paperboard web by applying a. a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web, weight of the precoating layer being less than 30 g/m 2, and b. a second coating composition in form of an aqueous polymer dispersion in a curtain coating unit for forming at least one barrier coating layer having a weight less than 20 g/m 2 on top of the precoating layer, and c. a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer, having a weight less than 20 g/m 2, on top of the barrier coating layer, whereby the second and third coating layers are applied simultaneously as aqueous dispersions without intermediate drying between the coating layers, a. a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web, weight of the precoating layer being less than 30 g/m 2, and b. a second coating composition in form of an aqueous polymer dispersion in a curtain coating unit for forming at least one barrier coating layer having a weight less than 20 g/m 2 on top of the precoating layer, and c. a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer, having a weight less than 20 g/m 2, on top of the barrier coating layer, - controlling and adjusting the temperature of the coated paperboard web in a adjustable heating unit, which is configured to control and adjust the temperature of the paperboard web and to remove water therefrom, and - cooling the paperboard web in at least one cooling unit.
An apparatus for wireless communication, comprising: two or more transceiver array groups (802, 804), each transceiver array group (802, 804) comprising one or more radio frequency, RF, circuits (300a, 301a, 806, 807), and one or more RF front end, RF FE, circuits (300b, 301b, 808, 809); wherein the transceiver array groups (802, 804) are configured to operate at different frequencies; wherein the transceiver array groups (802, 804) are configured to be connected to one corresponding digital baseband processor; wherein the transceiver array groups (802, 804) comprise at least one first transceiver array group configured to operate at cm wavelength or larger; characterized in that the transceiver array groups (802, 804) are configured to enable selective coupling of each RF circuit (300a, 301a, 806, 807) of one transceiver array group to one or more of the RF FE circuits (300b, 301b, 808, 809) of the same transceiver array group and vice versa, and wherein a first of the transceiver array groups includes a first RF FE circuit which is connected to an RF circuit and which does not have phase and amplitude control blocks, and a second of the transceiver array groups different from the first of the transceiver array groups includes a second RF FE circuit which is connected to an RF circuit and which comprises phase and amplitude control blocks. two or more transceiver array groups (802, 804), each transceiver array group (802, 804) comprising one or more radio frequency, RF, circuits (300a, 301a, 806, 807), and one or more RF front end, RF FE, circuits (300b, 301b, 808, 809); wherein the transceiver array groups (802, 804) are configured to operate at different frequencies; wherein the transceiver array groups (802, 804) are configured to be connected to one corresponding digital baseband processor; wherein the transceiver array groups (802, 804) comprise at least one first transceiver array group configured to operate at cm wavelength or larger; characterized in that the transceiver array groups (802, 804) are configured to enable selective coupling of each RF circuit (300a, 301a, 806, 807) of one transceiver array group to one or more of the RF FE circuits (300b, 301b, 808, 809) of the same transceiver array group and vice versa, and wherein a first of the transceiver array groups includes a first RF FE circuit which is connected to an RF circuit and which does not have phase and amplitude control blocks, and a second of the transceiver array groups different from the first of the transceiver array groups includes a second RF FE circuit which is connected to an RF circuit and which comprises phase and amplitude control blocks.