A compound of Formula, or a pharmaceutically acceptable salt thereof: wherein: R 1 is methyl; L a is C 1 -C 6 alkyl, C 3 -C 10 carbocycle, C 6 -C 10 aryl, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, carbocycle, aryl, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with halogen; R 2 is C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OH, C 6 -C 10 aryl, C 3 -C 10 carbocycle, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, alkenyl, alkynyl, aryl, carbocycle, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; R 3 is H, C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, SO 2 R 4, or S R 4, wherein the alkyl, alkenyl, or alkynyl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, halogen, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; R 4 is C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OH, C 6 -C 10 aryl, C 3 -C 10 carbocycle, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, alkenyl, alkynyl, aryl, carbocycle, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, halogen, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; or alternatively, R 2 and R 3, together with the atoms to which they are attached, form a cyclic moiety comprising one or two 5- or 6-membered rings, and optionally further comprising 1-5 additional heteroatoms selected from N, O and S, wherein the rings can be optionally substituted with oxo; and n is 1 or 2. R 1 is methyl; L a is C 1 -C 6 alkyl, C 3 -C 10 carbocycle, C 6 -C 10 aryl, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, carbocycle, aryl, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with halogen; R 2 is C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OH, C 6 -C 10 aryl, C 3 -C 10 carbocycle, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, alkenyl, alkynyl, aryl, carbocycle, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; R 3 is H, C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, SO 2 R 4, or S R 4, wherein the alkyl, alkenyl, or alkynyl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, halogen, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; R 4 is C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OH, C 6 -C 10 aryl, C 3 -C 10 carbocycle, heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, or heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, wherein the alkyl, alkenyl, alkynyl, aryl, carbocycle, heterocycle, or heteroaryl groups are optionally, independently substituted one or more times with C 1 -C 6 alkyl, OH, O(C 1 -C 6 alkyl), oxo, halogen, NH 2, N (C 1 -C 6 alkyl), N(C 1 -C 6 alkyl) 2, SO 2 H, SO 2 (C 1 -C 6 alkyl), CHO, CO 2 H, CO 2 (C 1 -C 6 alkyl), or CN; or alternatively, R 2 and R 3, together with the atoms to which they are attached, form a cyclic moiety comprising one or two 5- or 6-membered rings, and optionally further comprising 1-5 additional heteroatoms selected from N, O and S, wherein the rings can be optionally substituted with oxo; and n is 1 or 2.