A high reliability analyte detection device, wherein, including: a bottom case; a sensor, assembled on the bottom case, wherein the sensor includes a signal output portion and a detection portion, and the signal output portion, which has a shape of a polyline or an arc toward a top of the bottom case, is provided with at least two first electrical connection ends (316a, 316b, 316c) insulated from each other; a transmitter, fastened with the bottom case, wherein the transmitter is provided with at least two second electrical connection ends (322a, 322b, 322c) which are insulated from each other and correspond to the first electrical connection ends (316a, 316b, 316c) and one elastic member contacted with the signal output portion wherein the elastic member includes at least two conductive areas and at least one insulation area, and the insulation area is provided between two adjacent conductive areas of the at least two conductive areas and the at least two first electrical connection ends (316a, 316b, 316c), through different conductive areas, are respectively electrically connected to the corresponding second electrical connection ends (322a, 322b, 322c) of the second electrical connection ends, and the different first electrical connection ends (316a, 316b, 316c) or the different second electrical connection ends (322a, 322b, 322c) are respectively electrically connected to the different conductive areas; characterised in that the different first electrical connection ends (316a, 316b, 316c) are provided on different parts of the signal output portion which are independent of each other and do not interfere with each other; and wherein the signal output portion is embedded inside the elastic member and the embedding heights of the different parts of the signal output portion (3 13a) in the elastic member are not exactly the same. a bottom case; a sensor, assembled on the bottom case, wherein the sensor includes a signal output portion and a detection portion, and the signal output portion, which has a shape of a polyline or an arc toward a top of the bottom case, is provided with at least two first electrical connection ends (316a, 316b, 316c) insulated from each other; a transmitter, fastened with the bottom case, wherein the transmitter is provided with at least two second electrical connection ends (322a, 322b, 322c) which are insulated from each other and correspond to the first electrical connection ends (316a, 316b, 316c) and one elastic member contacted with the signal output portion wherein the elastic member includes at least two conductive areas and at least one insulation area, and the insulation area is provided between two adjacent conductive areas of the at least two conductive areas and the at least two first electrical connection ends (316a, 316b, 316c), through different conductive areas, are respectively electrically connected to the corresponding second electrical connection ends (322a, 322b, 322c) of the second electrical connection ends, and the different first electrical connection ends (316a, 316b, 316c) or the different second electrical connection ends (322a, 322b, 322c) are respectively electrically connected to the different conductive areas; characterised in that the different first electrical connection ends (316a, 316b, 316c) are provided on different parts of the signal output portion which are independent of each other and do not interfere with each other; and wherein the signal output portion is embedded inside the elastic member and the embedding heights of the different parts of the signal output portion (3 13a) in the elastic member are not exactly the same.