A tissue grasping device (1, 1B, 2) comprising: a longitudinal axis member which is configured to be capable of being inserted into a body; a first actuating member and a second actuating member provided at a distal end portion of the longitudinal axis member and configured to be capable of grasping a tissue, the second actuating member being configured to approach, respectively to separate from, the first actuating member to thereby perform an open-close operation; and a first wire member (31A, 61A), extending outwardly from the first actuating member and being curved in a loop shape, and a second wire member, extending outwardly from the second actuating member and being curved in a loop shape; wherein the tissue grasping device (1, 1B, 2) further comprises: a first distal end through hole provided on a distal end surface of the first actuating member, and a first side surface through hole provided on a side surface of the first actuating member; and a second distal end through hole provided on a distal end surface of the second actuating member and a second side surface through hole provided on a side surface of the second actuating member, wherein the first wire member (31A, 61A) forms a first loop portion which is curved in a loop shape between a point existing to the outside of the first actuating member through the first distal end through hole and a point returning to an inside of the first actuating member through the first side surface through hole, and wherein the second wire member forms a second loop portion which is curved in a loop shape between a point existing to the outside of the second actuating member through the second distal end through hole and a point returning to an inside of the second actuating member through the second side surface through hole. a longitudinal axis member which is configured to be capable of being inserted into a body; a first actuating member and a second actuating member provided at a distal end portion of the longitudinal axis member and configured to be capable of grasping a tissue, the second actuating member being configured to approach, respectively to separate from, the first actuating member to thereby perform an open-close operation; and a first wire member (31A, 61A), extending outwardly from the first actuating member and being curved in a loop shape, and a second wire member, extending outwardly from the second actuating member and being curved in a loop shape; wherein the tissue grasping device (1, 1B, 2) further comprises: a first distal end through hole provided on a distal end surface of the first actuating member, and a first side surface through hole provided on a side surface of the first actuating member; and a second distal end through hole provided on a distal end surface of the second actuating member and a second side surface through hole provided on a side surface of the second actuating member, a first distal end through hole provided on a distal end surface of the first actuating member, and a first side surface through hole provided on a side surface of the first actuating member; and a second distal end through hole provided on a distal end surface of the second actuating member and a second side surface through hole provided on a side surface of the second actuating member, wherein the first wire member (31A, 61A) forms a first loop portion which is curved in a loop shape between a point existing to the outside of the first actuating member through the first distal end through hole and a point returning to an inside of the first actuating member through the first side surface through hole, and wherein the second wire member forms a second loop portion which is curved in a loop shape between a point existing to the outside of the second actuating member through the second distal end through hole and a point returning to an inside of the second actuating member through the second side surface through hole.