A multi-zone downhole testing assembly (112, 200), comprising: a cylindrical body configured to be disposed in a wellbore extending into a formation, the cylindrical body comprising a central bore extending between a first, uphole end of the cylindrical body and a second, downhole end opposite the first, uphole end of the cylindrical body; an open hole packer that circumscribes the cylindrical body, the open hole packer configured to engage and seal against an open hole surface of the wellbore to define a first open-hole zone of the wellbore downhole of the open hole packer, wherein the open hole packer comprises a first hydraulic packer, the first hydraulic packer configured to activate in response to a pressure in the central bore greater than a first threshold pressure; a first cased hole packer that circumscribes the cylindrical body uphole of the open hole packer, the first cased hole packer configured to engage and seal against a first portion of a casing of the wellbore to define a second open-hole zone of the wellbore between the first cased hole packer and the open hole packer, wherein the first cased hole packer comprises a second hydraulic packer, the second hydraulic packer configured to activate in response to a pressure in the central bore greater than a second threshold pressure greater than or equal to the first threshold pressure; and a second cased hole packer that circumscribes the cylindrical body, the second cased hole packer configured to engage and seal against a second portion of the casing uphole of the first portion to define a cased zone of the wellbore between the second cased hole packer and the first cased hole packer. a cylindrical body configured to be disposed in a wellbore extending into a formation, the cylindrical body comprising a central bore extending between a first, uphole end of the cylindrical body and a second, downhole end opposite the first, uphole end of the cylindrical body; an open hole packer that circumscribes the cylindrical body, the open hole packer configured to engage and seal against an open hole surface of the wellbore to define a first open-hole zone of the wellbore downhole of the open hole packer, wherein the open hole packer comprises a first hydraulic packer, the first hydraulic packer configured to activate in response to a pressure in the central bore greater than a first threshold pressure; a first cased hole packer that circumscribes the cylindrical body uphole of the open hole packer, the first cased hole packer configured to engage and seal against a first portion of a casing of the wellbore to define a second open-hole zone of the wellbore between the first cased hole packer and the open hole packer, wherein the first cased hole packer comprises a second hydraulic packer, the second hydraulic packer configured to activate in response to a pressure in the central bore greater than a second threshold pressure greater than or equal to the first threshold pressure; and a second cased hole packer that circumscribes the cylindrical body, the second cased hole packer configured to engage and seal against a second portion of the casing uphole of the first portion to define a cased zone of the wellbore between the second cased hole packer and the first cased hole packer.