mhurhangee/ep-ind-claims huggingface dataset:
A gapped oligonucleotide analog for use in therapy comprising two external regions separated by an internal region wherein the internal region comprises from 6 to 12 contiguous β-D-2'-deoxyribonucleosides and each external region independently comprises from 1 to 5 contiguous tricyclic nucleosides wherein each tricyclic nucleoside has formula II: wherein independently for each of said tricyclic nucleoside having formula II: Bx is a heterocyclic base moiety; one of T 1 and T 2 is an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligonucleotide analog and the other of T 1 and T 2 is hydroxyl, a protected hydroxyl, a phosphate moiety, a 5' or 3'-terminal group or an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligonucleotide analog; q 1, q 2, q 3, q 4, z 1 and z 2 are each H; wherein each internucleoside linking group is a phosphorothioate and wherein said oligonucleotide analog is complementary to at least a portion of a target RNA. Bx is a heterocyclic base moiety; one of T 1 and T 2 is an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligonucleotide analog and the other of T 1 and T 2 is hydroxyl, a protected hydroxyl, a phosphate moiety, a 5' or 3'-terminal group or an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligonucleotide analog; q 1, q 2, q 3, q 4, z 1 and z 2 are each H; wherein each internucleoside linking group is a phosphorothioate and wherein said oligonucleotide analog is complementary to at least a portion of a target RNA.
A charger adopted to charge either one of a first-type battery pack and a second-type battery pack, wherein the both the first-type battery pack and the second-type battery pack have an insertion portion (102a or 202a) respectively, and the shape of the insertion portion of the first-type battery pack is different from the shape of the insertion portion of the second-type battery pack, the charger comprising: a housing having a battery pack socket into which the insertion portion of the first-type battery pack and the insertion portion of the second-type battery pack can be selectively inserted in a prescribed attitude; a charging control unit housed in the housing; and at least a pair of output terminals (26 and 28) disposed in the battery pack socket wherein the output terminals (26 and 28) is electrically connected to the first-type battery pack when the insertion portion of the first-type battery pack in the prescribed attitude is inserted into the battery pack socket and the pair of output terminals is electrically connected to the second-type battery pack when the insertion portion of the second-type battery pack in the prescribed attitude is inserted into the battery pack socket, characterized in that an opening shape of the battery pack socket has a shape of two ellipses orthogonally overlapping each other with centers of the ellipses that are arranged along a longitudinal center line of one of the ellipses such that the shape does not allow insertion of the insertion portion of the first-type battery pack that is not in the prescribed attitude into the battery pack socket. a housing having a battery pack socket into which the insertion portion of the first-type battery pack and the insertion portion of the second-type battery pack can be selectively inserted in a prescribed attitude; a charging control unit housed in the housing; and at least a pair of output terminals (26 and 28) disposed in the battery pack socket wherein the output terminals (26 and 28) is electrically connected to the first-type battery pack when the insertion portion of the first-type battery pack in the prescribed attitude is inserted into the battery pack socket and the pair of output terminals is electrically connected to the second-type battery pack when the insertion portion of the second-type battery pack in the prescribed attitude is inserted into the battery pack socket, characterized in that an opening shape of the battery pack socket has a shape of two ellipses orthogonally overlapping each other with centers of the ellipses that are arranged along a longitudinal center line of one of the ellipses such that the shape does not allow insertion of the insertion portion of the first-type battery pack that is not in the prescribed attitude into the battery pack socket.
A washing machine comprising a drum rotated by a motor around the horizontal axis, wherein the laundry is placed, a tub wherein the drum moves, a shaft that transfers the movement received from the motor to the drum, a hub disposed at the center of the rear wall of the tub, which is stationary together with the tub and wherein the shaft is supported, at least one baffle disposed at the inner surface of the drum and wherein water is transferred in case of an unbalanced load, a cylindrical housing disposed at the center of the rear wall of the drum, surrounding the hub concentrically such that there remains a gap therebetween and rotating together with the drum, more than one ring-shaped gasket arranged one after the other and in parallel to each other in the gap between the housing and the hub, more than one slot disposed between the gaskets, at least one water inlet line which provides water taken from the water mains to be delivered to the slot for the balancing process of the unbalanced load, one end of which is connected to the water mains and the other end connected to the slot and which is stationary together with the tub, at least one separator placed at the inner region of the baffle and separating the inner volume of the baffle into two or more parts, at least two chambers (13, 113) disposed in the baffle, into which water is delivered according to the unbalanced load status and that the separator separates from each other, at least two distribution lines (14, 114) which provide water to be delivered to the chambers (13, 113) from the slot, a control unit which opens/closes water inlet valves by determining the amount and position of the unbalanced load when unbalanced load is detected and which determines how much water should be delivered into which baffle and chamber (13, 113), characterized by at least one valve placed at the outlet of the slot, connected to the distribution lines (14, 114) and guides water taken from the slot to the first chamber or the second chamber in the baffle when unbalanced load is detected by the control unit and thus provides the chambers (13, 113) in the baffle to be supplied from the same slot.
A crosslinkable rubber composition comprising: a carboxyl group-containing nitrile rubber containing a halogen or a halogen compound, and having an iodine value of 120 or less; a polyamine-based crosslinking agent; and a metal-based acid acceptor selected from oxides of metals belonging to Group 2, 12 or 13 of the Periodic Table, hydroxides of metals belonging to Group 13 of the Periodic Table, hydrotalcites, and any combination thereof. a carboxyl group-containing nitrile rubber containing a halogen or a halogen compound, and having an iodine value of 120 or less; a polyamine-based crosslinking agent; and a metal-based acid acceptor selected from oxides of metals belonging to Group 2, 12 or 13 of the Periodic Table, hydroxides of metals belonging to Group 13 of the Periodic Table, hydrotalcites, and any combination thereof.
A soil recycler having a housing for receiving a soil recycling device that has an upper housing side and a lower housing side as well as two opposed front and rear housing sides as well as two opposed housing side faces (22, 24), wherein the front housing side has an opening for receiving the material to be recycled and the rear housing side has an opening for dispensing the recycled material, and a coupling apparatus for coupling to an excavator or construction machine on the top housing side is provided, characterized in that the housing has a first receiving device for receiving a pair of fork tines of a lifting fork, wherein the first receiving device includes two spaced-apart recesses (34, 34', 34") which are embodied such that the respective fork tines of the lifting fork can each engage the recesses, and the recesses (34, 34', 34") are in particular located on either side of the coupling device, and wherein the first receiving device is located in the vicinity of the upper housing side and/or the lower housing side and/or the rear housing side, and the recesses (34, 34', 34"), in particular beginning at the upper housing side and/or the lower housing side and/or the rear housing side extend in the direction of the respective opposite side.
Method for manufacturing a strip of impregnated anodised aluminium, intended to be used in a coil of an electrotechnical component, said coil comprising an interstitial material providing the functions of cohesion and dielectric isolation, said interstitial material being obtained from a precursor mixture able to cross-link, said method comprising: - a step of applying the precursor mixture of said interstitial material to the anodised aluminium, - at least one step of cross-linking the precursor mixture in order to form said interstitial material on the aluminium strip; characterised in that anodised aluminium has not undergone sealing of the pores of the alumina formed by anodising before application of the precursor mixture of said interstitial material. - a step of applying the precursor mixture of said interstitial material to the anodised aluminium, - at least one step of cross-linking the precursor mixture in order to form said interstitial material on the aluminium strip;
Hand-held work apparatus having a housing in which a combustion engine for driving a tool of the work apparatus is arranged, having a fuel tank, having a control device for controlling at least one electric component of the work apparatus, wherein the control device is an electronic control device, wherein the control device is connected to at least one electric component of the work apparatus, and wherein the work apparatus has a top side which faces upwards when the work apparatus is set down in a normal set-down position on a flat, horizontal set-down surface, wherein at least one operating element for operating the combustion engine is arranged on a handle of the work apparatus, wherein the handle has a longitudinal central axis, and wherein a longitudinal plane of the work apparatus is oriented perpendicularly in the set-down position and contains the longitudinal central axis of the handle, characterized in that the control device, in the normal set-down position, is arranged laterally next to the fuel tank, perpendicularly to the longitudinal plane, with regard to the longitudinal plane of the work apparatus.
An ultrasonic measurement apparatus for measuring the flow velocity of a fluid which flows in a pipeline in a main flow direction, having at least one pair of ultrasonic transducers at a measurement path in an ultrasonic measurement region which is configured for a fluid to flow on a straight measurement line in a measurement flow direction, wherein the ultrasonic measurement apparatus comprises a pipe shaped base piece with connection flanges (16a, 16b) for the pipeline as well as a socket pipe having a supply region (30, 22, 36, 24) and the ultrasonic measurement region and being arranged at an angle with respect to the base piece, wherein the supply region (30, 22, 36, 24) is configured to deflect the fluid from the main flow direction and to guide the fluid to the ultrasonic measurement region so that the measurement flow direction and the main flow direction are arranged at the angle to one another and wherein the supply region (30, 22, 36, 24) is designed bent in itself so that the fluid is guided at first in an inflow region of the socket pipe from the base piece to the opposite end of the socket pipe and afterwards guided back in an outflow region to the base piece, characterized in that the ultrasonic measurement apparatus is configured as a gas meter for gas flowmetering in a gas pipeline, in that the measurement path is arranged transverse to the flow of the fluid, and in that the ultrasonic measurement region is arranged in the outflow region.
A turbocharger system comprising: a housing that comprises a through bore, a plurality of lubricant bores (562, 564), a plurality of lubricant bore to through bore openings, a recessed compressor-side surface that defines in part a passage that fluidly couples at least two of the lubricant bores (562, 564), and radial recesses (582, 584) that extend radially outwardly from the through bore; a rolling element bearing unit disposed at least in part in the through bore of the housing; and a plate that covers at least a portion of the recessed compressor-side surface of the housing, wherein: one of the radial recesses is in fluid communication with one of the plurality of lubricant bores and is a gravity support radial recess where, in use, acceleration of gravity acts upon the rolling element bearing unit and flow of fluid to the gravity support radial recess counteracts the effect such that the rolling element bearing unit lifts off of a bore wall in the through bore of the housing. a housing that comprises a through bore, a plurality of lubricant bores (562, 564), a plurality of lubricant bore to through bore openings, a recessed compressor-side surface that defines in part a passage that fluidly couples at least two of the lubricant bores (562, 564), and radial recesses (582, 584) that extend radially outwardly from the through bore; a rolling element bearing unit disposed at least in part in the through bore of the housing; and a plate that covers at least a portion of the recessed compressor-side surface of the housing, wherein: one of the radial recesses is in fluid communication with one of the plurality of lubricant bores and is a gravity support radial recess where, in use, acceleration of gravity acts upon the rolling element bearing unit and flow of fluid to the gravity support radial recess counteracts the effect such that the rolling element bearing unit lifts off of a bore wall in the through bore of the housing.
A method for transmitting a data resource acquisition request, the method comprising: when there is a need to transmit an acquisition request for a first data source, acquiring, by a first node, traffic scheduling information of a plurality of secondary nodes stored locally corresponding to a source server to which the first data source belongs, wherein the traffic scheduling information includes traffic-to-be-split domain name level and traffic-to-be-split ratio; selecting, by the first node, a target node among the plurality of secondary nodes based on the traffic scheduling information of the plurality of secondary nodes; and transmitting, by the first node, the acquisition request for the first data source to the target node. when there is a need to transmit an acquisition request for a first data source, acquiring, by a first node, traffic scheduling information of a plurality of secondary nodes stored locally corresponding to a source server to which the first data source belongs, wherein the traffic scheduling information includes traffic-to-be-split domain name level and traffic-to-be-split ratio; selecting, by the first node, a target node among the plurality of secondary nodes based on the traffic scheduling information of the plurality of secondary nodes; and transmitting, by the first node, the acquisition request for the first data source to the target node.
A biocompatible drug delivery system for use in a low dose method for treating dry age-related macular degeneration, the drug delivery system comprising between 5 μg and 20 μg of bevacizumab and a polymeric hyaluronic acid vehicle associated with the bevacizumab; wherein the method comprises the step of injecting the drug delivery system into the vitreous of an eye of a patient with dry AMD; and wherein the drug delivery system releases between 14 ng and 120 ng of bevacizumab over a 24 hour period for between 3 months and 6 months.
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein, W is O or S; Ring A is substituted or unsubstituted phenyl or substituted or unsubstituted pyridyl; Ring B is substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 1 and L 2 are independently substituted or unsubstituted (C 1 -C 5) alkylene; R 1 is substituted or unsubstituted (C 1 -C 5) alkyl; R 2 is hydrogen, or substituted or unsubstituted (C 1 -C 5) alkyl; R 1 and R 2 may optionally be joined to form a substituted or unsubstituted 3 to 6 membered heterocycloalkyl; L 1 and R 1 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl; L 1 and R 2 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl; L 3 is a -N(R 6)-; R 5 is hydrogen or substituted or unsubstituted (C 1 -C 5) alkyl; and R 6 is hydrogen or substituted or unsubstituted (C 1 -C 5) alkyl. or a pharmaceutically acceptable salt thereof, wherein, W is O or S; Ring A is substituted or unsubstituted phenyl or substituted or unsubstituted pyridyl; Ring B is substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 1 and L 2 are independently substituted or unsubstituted (C 1 -C 5) alkylene; R 1 is substituted or unsubstituted (C 1 -C 5) alkyl; R 2 is hydrogen, or substituted or unsubstituted (C 1 -C 5) alkyl; R 1 and R 2 may optionally be joined to form a substituted or unsubstituted 3 to 6 membered heterocycloalkyl; L 1 and R 1 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl; L 1 and R 2 may optionally be joined to form a substituted or unsubstituted 4 to 8 membered heterocycloalkyl; L 3 is a -N(R 6)-; R 5 is hydrogen or substituted or unsubstituted (C 1 -C 5) alkyl; and R 6 is hydrogen or substituted or unsubstituted (C 1 -C 5) alkyl.
A gas meter comprising: a meter entrance that allows a fluid to flow in; a meter exit that allows the fluid to flow out; and a flow rate measurer that measures a flow rate of the fluid; wherein the flow rate measurer includes a plurality of flow rate measuring units of a same shape, each of which is composed of a flow passage portion having a rectangular cross sectional shape on the outer side and a sensor portion disposed on one face of the flow passage portion, characterized in that the gas meter comprises a connecting member that is connected to the meter exit, the plurality of flow rate measuring units are integrally bonded together by bonding faces on a side opposite to faces having sensor portion, and an exit of the flow rate measurer is configured to be inserted into the connecting member and held. a meter entrance that allows a fluid to flow in; a meter exit that allows the fluid to flow out; and a flow rate measurer that measures a flow rate of the fluid; wherein the flow rate measurer includes a plurality of flow rate measuring units of a same shape, each of which is composed of a flow passage portion having a rectangular cross sectional shape on the outer side and a sensor portion disposed on one face of the flow passage portion, characterized in that the gas meter comprises a connecting member that is connected to the meter exit, the plurality of flow rate measuring units are integrally bonded together by bonding faces on a side opposite to faces having sensor portion, and an exit of the flow rate measurer is configured to be inserted into the connecting member and held.
A client computer for querying a database stored on a server via a network, the server being coupled to the client computer via the network, wherein the database comprises first data items and suffix items, wherein each suffix item describes a suffix of at least one first data item of the first data items having removed on its left side a number of its symbols, wherein for each suffix item a first referential connection exists in the database assigning said suffix item to the at least one first data item comprising the suffix of said suffix item, wherein each suffix item is encrypted with a suffix cryptographic key in the database, wherein each first data item is encrypted with a first cryptographic key in the database, wherein the client computer has installed thereon an application program, the application program being operational to: - receiving a search request, the search request specifying a postfix search on a search criterion, the postfix search comprising a wildcard search with one or more wildcards on the left side of the search criterion, - determining one of the suffix items of the database that matches the search criterion, - providing to the database a request for providing the one or more encrypted first data items being assigned via the first referential connection to the determined suffix item matching the search criterion, - receiving from the database the requested encrypted first data items and decrypting said received first data items. - receiving a search request, the search request specifying a postfix search on a search criterion, the postfix search comprising a wildcard search with one or more wildcards on the left side of the search criterion, - determining one of the suffix items of the database that matches the search criterion, - providing to the database a request for providing the one or more encrypted first data items being assigned via the first referential connection to the determined suffix item matching the search criterion, - receiving from the database the requested encrypted first data items and decrypting said received first data items.
A method of making a multi-wall, flash-free ceramic core (CC, 20, 20', 20", 20"') for casting an airfoil with one or more internal cooling passages, comprising preforming at least one fugitive core insert (1, 10, 100, 200) to have a joint-forming surface with a male and/or female joint feature, then forming at least one additional fugitive core insert (1, 10, 100, 200) in-situ adjacent and integrally connected to said at least one preformed core insert at said joint-forming surface to form an interlocked, over-molded, fused joint having an interlocked male joint feature (F, F') and female joint feature (F, F') to form a composite core insert that includes features to form internal passage surfaces in the ceramic core when the composite core insert is removed wherein some of said features reside in different planes that the composite core insert cannot be formed as one piece as a result of complex core geometry, placing the composite core insert in a core molding die cavity, introducing a fluid ceramic material into the die cavity to form a ceramic core body incorporating the composite core insert wherein the over-molded, fused joint is hidden internal of the ceramic core body and is so sealed as to prevent internal core body molding flash that cannot be detected or removed, and removing the ceramic core body from the die cavity, and selectively removing the composite core insert to yield a flash-free ceramic core having said internal passage surfaces.