mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing a compound having formula: the method comprising contacting a compound of formula with R 1 -Y in a solvent, in the presence of a palladium catalyst selected from dichloro[1,1'-bis(ditert-butylphosphino)ferrocene]palladium and dichlorobis(p-dimethylamino phenylditbutylphosphine)palladium, wherein said contacting occurs under conditions suitable to provide a compound of formula, wherein: X is halogen, B(OR +) 2 or Sn(R ++) 3; Y is halogen, triflate, B(OR +) 2 or Sn(R ++) 3; wherein a) when X is halogen, then Y is B(OR +) 2 or Sn(R ++) 3; or b) when Y is halogen or triflate, then X is B(OR +) 2 or Sn(R ++) 3; wherein each R + is independently hydrogen or substituted or unsubstituted C 1-3 alkyl, or each R +, together with the boron atom and the atoms to which they are attached, form a cyclic boronate; and each R ++ is a C 1-3 alkyl; and wherein: R 1 is substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylalkyl; R 2 is H, substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl; R 3 is H, or a substituted or unsubstituted C 1-8 alkyl; provided the compound of formula is not 7-(4-hydroxyphenyl)-1-(3-methoxybenzyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 -one. X is halogen, B(OR +) 2 or Sn(R ++) 3; Y is halogen, triflate, B(OR +) 2 or Sn(R ++) 3; wherein a) when X is halogen, then Y is B(OR +) 2 or Sn(R ++) 3; or b) when Y is halogen or triflate, then X is B(OR +) 2 or Sn(R ++) 3; a) when X is halogen, then Y is B(OR +) 2 or Sn(R ++) 3; or b) when Y is halogen or triflate, then X is B(OR +) 2 or Sn(R ++) 3; R 1 is substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylalkyl; R 2 is H, substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl; R 3 is H, or a substituted or unsubstituted C 1-8 alkyl; provided the compound of formula is not 7-(4-hydroxyphenyl)-1-(3-methoxybenzyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 -one.
A communication device arranged for transmitting information from a medicament delivery device including at least one physical part such as springs, drivers, rotators, sleeves, rods and indicators providing a translational movement when a state of change occurs in the medicament delivery device, the communication device comprises - at least one translation detection arrangement, configured to detect a translation of at least one physical part of said medicament delivery device by utilization of a resilience and an electrical conductivity for at least one spring (45,145) of said medicament delivery device; - at least one change of state detection unit, configured to detect at least one change of state; - at least one activation unit, configured to activate said at least one change of state detection unit and - at least one transmission unit (104, 304) configured to provide a wireless transmission of information related to said at least one change of state to an external receiving device, wherein the communication device also includes at least one determination unit configured to determine information related to a medicament delivery performed by the medicament delivery device, wherein information is based on preconfigured data and/or measured data related to the medicament delivery, characterized in that the communication device uses at least one spring of the medicament delivery device in combination with a first connector of the communication device and a second connector of the communication device, in order to achieve a function of a translation switch. - at least one translation detection arrangement, configured to detect a translation of at least one physical part of said medicament delivery device by utilization of a resilience and an electrical conductivity for at least one spring (45,145) of said medicament delivery device; - at least one change of state detection unit, configured to detect at least one change of state; - at least one activation unit, configured to activate said at least one change of state detection unit and - at least one transmission unit (104, 304) configured to provide a wireless transmission of information related to said at least one change of state to an external receiving device, wherein the communication device also includes at least one determination unit configured to determine information related to a medicament delivery performed by the medicament delivery device, wherein information is based on preconfigured data and/or measured data related to the medicament delivery, characterized in that the communication device uses at least one spring of the medicament delivery device in combination with a first connector of the communication device and a second connector of the communication device, in order to achieve a function of a translation switch.
An antigen delivery system consisting essentially of PEGylated stealth liposomes loaded with an immunogenic human leukocyte antigen class I restricted peptide and surface-modified with a cancer-specific cell targeting peptide which mediates binding and internalization of the liposomes into a target cell, wherein the cell-targeting peptide is H1299.3, wherein the delivery system does not contain any viral particles or toxins.
A lighting system intended to be fitted to a swimming pool wall, said lighting system comprising: a) a wall feed-through element in the form of a cylindrical sleeve whose inner surface is provided with a female thread, b) a lighting device comprising: - a lighting support provided with a front face, a rear face and a through-hole, - lighting means integral with said front face of said lighting support, - means for fastening said lighting support to said wall feed-through element, and - a cable for the power supply of said lighting means, said power cable extending through said through-hole of said lighting support, characterized in that said wall feed-through element is intended to be fastened into the wall of a swimming pool to delimit a through-passage of said wall, through which said cable is intended to extend, and in that said means for fastening said lighting support to said wall feed-through element comprise: - an interlock connector integral with said lighting support, provided with first interlock means (23a1), and - a fastening ring provided with a male thread (23b1) adapted to cooperate with said female thread of said wall feed-through element, said fastening ring including second interlock means (23b2) adapted to cooperate with said first interlock means (23a1) of said interlock connector. a) a wall feed-through element in the form of a cylindrical sleeve whose inner surface is provided with a female thread, b) a lighting device comprising: - a lighting support provided with a front face, a rear face and a through-hole, - lighting means integral with said front face of said lighting support, - means for fastening said lighting support to said wall feed-through element, and - a cable for the power supply of said lighting means, said power cable extending through said through-hole of said lighting support, characterized in that said wall feed-through element is intended to be fastened into the wall of a swimming pool to delimit a through-passage of said wall, through which said cable is intended to extend, and in that said means for fastening said lighting support to said wall feed-through element comprise: - an interlock connector integral with said lighting support, provided with first interlock means (23a1), and - a fastening ring provided with a male thread (23b1) adapted to cooperate with said female thread of said wall feed-through element, said fastening ring including second interlock means (23b2) adapted to cooperate with said first interlock means (23a1) of said interlock connector. - a lighting support provided with a front face, a rear face and a through-hole, - lighting means integral with said front face of said lighting support, - means for fastening said lighting support to said wall feed-through element, and - a cable for the power supply of said lighting means, said power cable extending through said through-hole of said lighting support, - an interlock connector integral with said lighting support, provided with first interlock means (23a1), and - a fastening ring provided with a male thread (23b1) adapted to cooperate with said female thread of said wall feed-through element,
A circuit for multiplexing multiple channels of voice signals, wherein the circuit comprises: a micro control unit(100; 200), MCU, wherein the MCU comprises at least two general purpose input/output GPIO interfaces(100-1,100-2; 200-1, 200-2); and at least two subscriber line interface circuits SLICs(101,102; 201, 202), wherein each of the at least two SLICs(101,102; 201, 202) comprises an enabling, CS, port; the CS port of each of the at least two SLICs(101,102; 201, 202) is separately connected to the at least two GPIO interfaces(100-1,100-2; 200-1, 200-2); and the at least two GPIO interfaces (100-1,100-2; 200-1, 200-2) generate an enabling signal, characterized in that said at least two GPIO interfaces enable the at least two SLICs(101,102; 201, 202) in a time division manner by using the CS port of each of the at least two SLICs(101,102; 201, 202). a micro control unit(100; 200), MCU, wherein the MCU comprises at least two general purpose input/output GPIO interfaces(100-1,100-2; 200-1, 200-2); and at least two subscriber line interface circuits SLICs(101,102; 201, 202), wherein each of the at least two SLICs(101,102; 201, 202) comprises an enabling, CS, port; the CS port of each of the at least two SLICs(101,102; 201, 202) is separately connected to the at least two GPIO interfaces(100-1,100-2; 200-1, 200-2); and the at least two GPIO interfaces (100-1,100-2; 200-1, 200-2) generate an enabling signal, characterized in that said at least two GPIO interfaces enable the at least two SLICs(101,102; 201, 202) in a time division manner by using the CS port of each of the at least two SLICs(101,102; 201, 202).
An automated method for monitoring the amount of a nutriment taken up by an animal or group of animals feeding or drinking from a nutriment supply station wherein said method comprises the steps of: a. acquiring data on the vibration of said nutriment supply station and/or on the impact sounds transmitted through said feed supply station; b. analyzing said vibration or impact sound data in order to identify and count individual signals, referred to as nutriment uptake signals, resulting from a nutriment uptake action of an animal feeding or drinking from said nutriment supply station; and c. extrapolating the amount of nutriment taken up by said animal or group of animals within a given period of time based on the number of nutriment uptake signals recorded over said same period of time. a. acquiring data on the vibration of said nutriment supply station and/or on the impact sounds transmitted through said feed supply station; b. analyzing said vibration or impact sound data in order to identify and count individual signals, referred to as nutriment uptake signals, resulting from a nutriment uptake action of an animal feeding or drinking from said nutriment supply station; and c. extrapolating the amount of nutriment taken up by said animal or group of animals within a given period of time based on the number of nutriment uptake signals recorded over said same period of time.
An apparatus for dissection and coagulation of tissue, comprising: a surgical instrument having an end effector configured to dissect and seal tissue at a distal end thereof; a generator electrically coupled to the surgical instrument and configured to deliver energy to the end effector; and a surgical mode selector input having a plurality of surgical modes for selection by a user such that each surgical mode corresponds to an algorithm for controlling the power delivered from the generator to the end effector, wherein the surgical instrument includes a closure switch configured to move between a first position in which the end effector is opened to allow tissue to be positioned within the end effector and a second position in which the end effector is closed such that tissue to held by the end effector, wherein one or more of the algorithms corresponding to the plurality of surgical modes includes a threshold counter for counting the number of activations of the end effector when the closure switch is in the second position such that the power output from the generator can be varied as a function of the number of activations of the end effector when the closure switch is in the second position. a surgical instrument having an end effector configured to dissect and seal tissue at a distal end thereof; a generator electrically coupled to the surgical instrument and configured to deliver energy to the end effector; and a surgical mode selector input having a plurality of surgical modes for selection by a user such that each surgical mode corresponds to an algorithm for controlling the power delivered from the generator to the end effector, wherein the surgical instrument includes a closure switch configured to move between a first position in which the end effector is opened to allow tissue to be positioned within the end effector and a second position in which the end effector is closed such that tissue to held by the end effector, wherein one or more of the algorithms corresponding to the plurality of surgical modes includes a threshold counter for counting the number of activations of the end effector when the closure switch is in the second position such that the power output from the generator can be varied as a function of the number of activations of the end effector when the closure switch is in the second position.
Refrigeration unit having at least one housing part, wherein the housing part is formed by means of a door, and wherein the housing part has at least one outer wall, wherein at least one receiving slot for receiving an electronic module is provided behind the outer wall in the housing part, the inlet opening of said receiving slot being accessible from an outer edge of the housing part, wherein the receiving slot runs substantially parallel to the top edge or bottom edge of the outer wall of the housing part, wherein the inlet opening of the receiving slot is provided on a vertical longitudinal edge of the outer wall of the respective housing part, characterised in that outer wall is formed in its entirety by means of a glass panel, wherein a heat-insulating material layer is installed behind the outer wall of the housing part, and that the outer wall is the front wall of the door, which is formed in its entirety solely by means of the glass panel which is integrated into the structural design of the door as a composite component.
A method performed by a wireless transmitter for resource block-level index modulation, the method comprising: determining data for transmission to a wireless receiver (110, 120); modulating a first portion of the data to provide modulation symbols that correspond to the first portion of the data; selecting, based on a data value of a second portion of the data, respective index locations for one or more resource blocks by which to transmit the modulation symbols to the wireless receiver; scheduling transmission of the modulation symbols in the one or more resource blocks having the respective index locations; transmitting an indication to the wireless receiver that the respective index locations of the one or more resource blocks indicate the second portion of the data; and transmitting the modulation symbols to the wireless receiver using the one or more resource blocks to convey the first portion of the data and the second portion of the data to the wireless receiver. determining data for transmission to a wireless receiver (110, 120); modulating a first portion of the data to provide modulation symbols that correspond to the first portion of the data; selecting, based on a data value of a second portion of the data, respective index locations for one or more resource blocks by which to transmit the modulation symbols to the wireless receiver; scheduling transmission of the modulation symbols in the one or more resource blocks having the respective index locations; transmitting an indication to the wireless receiver that the respective index locations of the one or more resource blocks indicate the second portion of the data; and transmitting the modulation symbols to the wireless receiver using the one or more resource blocks to convey the first portion of the data and the second portion of the data to the wireless receiver.
A composite barrier film comprising a base layer defining a base layer thickness, the base layer comprising a core layer comprising a polymer selected from the group consisting of polyolefin and polyester, and a barrier layer coextensively adjacent in direct contact with one side of the base layer, the barrier layer defining a barrier layer thickness and comprising modified polyvinyl amine, in which the modified polyvinyl amine is a vinylamine polymer crosslinked by citric acid, in which the composite barrier film is optically clear, and in which the composite barrier film has moisture vapor transmission rate and oxygen transmission rate at most equal to that of a composite control film consisting essentially of a substrate identical to the base layer, and a layer of polyvinyl alcohol of thickness equal to the barrier layer thickness and disposed coextensively on the substrate.
Forging machine with two bases, which can be moved mutually between a contact position and a drawn-back position, and the intermediate space between them, where the first base has a first working tool and the second base has a second working tool and the working tools are designed for pressing an object lying between them together with a form fit, wherein said forging machine comprises at least one carrying segment, on which a lubricating segment is mounted, that is movable in the intermediate space in order to spray the first and second working tools with lubricant, when the bases are in their drawn-back positions, the at least one carrying segment is in its starting position relative to the first working tool, and the at least one carrying segment and the lubricating segment are movably fastened to the forging machine in such a way that, when the bases move towards each other and the at least one carrying segment or the lubricating segment is brought into contact with the second base, this at least one carrying segment and the lubricating segment are moved, together with the second base, towards the first base or are pushed away from the second base in the direction of the first base and, when the bases move away from one another, are gradually returned to the starting position, characterised in that the at least one carrying segment is a pivot arm which is connected at one end to the lubricating segment and at the second end pivotably to the first base, wherein joint pivoting of the pivot arm and the lubricating segment takes place when the first base is moved towards the second base. wherein said forging machine comprises at least one carrying segment, on which a lubricating segment is mounted, that is movable in the intermediate space in order to spray the first and second working tools with lubricant, when the bases are in their drawn-back positions, the at least one carrying segment is in its starting position relative to the first working tool, and the at least one carrying segment and the lubricating segment are movably fastened to the forging machine in such a way that, when the bases move towards each other and the at least one carrying segment or the lubricating segment is brought into contact with the second base, this at least one carrying segment and the lubricating segment are moved, together with the second base, towards the first base or are pushed away from the second base in the direction of the first base and, when the bases move away from one another, are gradually returned to the starting position, characterised in that the at least one carrying segment is a pivot arm which is connected at one end to the lubricating segment and at the second end pivotably to the first base, wherein joint pivoting of the pivot arm and the lubricating segment takes place when the first base is moved towards the second base.
A cast ferritic stainless steel excellent in quality and workability, characterized by containing Cr: 11 to 17 wt% and Mg: 0.0005 to 0.010%, and Ti concentration [%Ti] and N concentration [%N] satisfying the following formula: % Ti × % N × ≥ % Cr 2.5 + 150 × 10 - 6, wherein [%Ti] designates the amount Ti, [%N] designates the amount of N, and [%Cr] designates the amount of Cr, in molten steel in terms of mass%, and containing not less than 100 pieces/cm 2 of inclusions composed of one or more of MgO, MgAl 2 O 3, TiN, CeS, Ce 2 O 3, CaS, ZrO 2, TiC, and VN having a size of not more than 10 μm, whose lattice incoherence with δ-ferrite formed during the solidification of molten steel is not more than 6%, and equiaxed crystals having not less than 60% of the cross section in the direction of the thickness of the cast stainless steel, wherein the lattice incoherence with δ-ferrite is defined as a value of the difference between the lattice constant of δ-ferrite formed by the solidification of molten steel and the lattice constant of metallic compound divided by the lattice constant of solidification nuclei in molten steel.