mhurhangee/ep-ind-claims huggingface dataset:
Probe for measuring uterine muscle activity in a non-pregnant uterus, the probe comprising: - an elongate member, and - one or more uterine cavity wall sensing electrodes, characterized in that the probe further comprises: - a reference electrode having a rounded tip arranged at a distal end of the elongate member, and - a uterine internal orifice sensing electrode arranged concentrically with the reference electrode, - wherein the one or more uterine cavity wall sensing electrodes are arranged between the reference electrode and the uterine internal orifice sensing electrode, - wherein the electrodes are separated by an interelectrode distance along the longitudinal axis of the probe, and - wherein the probe is configured such that, in use, the reference electrode is in contact with a fundus of the uterus while the uterine internal orifice electrode is in contact with a uterine internal orifice. - an elongate member, and - one or more uterine cavity wall sensing electrodes, characterized in that the probe further comprises: - a reference electrode having a rounded tip arranged at a distal end of the elongate member, and - a uterine internal orifice sensing electrode arranged concentrically with the reference electrode, - a reference electrode having a rounded tip arranged at a distal end of the elongate member, and - a uterine internal orifice sensing electrode arranged concentrically with the reference electrode, - wherein the one or more uterine cavity wall sensing electrodes are arranged between the reference electrode and the uterine internal orifice sensing electrode, - wherein the electrodes are separated by an interelectrode distance along the longitudinal axis of the probe, and - wherein the probe is configured such that, in use, the reference electrode is in contact with a fundus of the uterus while the uterine internal orifice electrode is in contact with a uterine internal orifice.
A transport device for transporting and handling containers, especially containers made of a thermoplastic material, wherein the containers are transported by the transport device in a transport direction from an input point to an output point, wherein the transport device has multiple handling devices, which are moving in the transport direction, for especially simultaneously handling one or more containers, and wherein the handling devices are arranged so that they are movable relative to the transport direction for a movement in a direction differing from the transport direction, wherein the transport device has at least one motor (32, 34, 37) by means of which the handling devices can be moved by a motor in the direction which differs from the transport direction, wherein the handling devices are configured to be pivotable by a motor with respect to the transport direction, wherein the transport device is configured as a rotating transfer wheel (15, 16, 17, 29) and wherein the handling devices are configured to perform at least one longitudinal movement as well as at least one rotational and/or one pivoting movement relative to the transport direction, characterised in that - the handling devices are adapted as transport arms, which are displaceable substantially radially to the transfer wheel, wherein retaining clips arranged at the radially outwardly positioned support arm ends can be adjusted in the tangential direction about a rotational axis, wherein this rotational axis is arranged parallel to the central rotational axis of the transfer wheel. - the handling devices are adapted as transport arms, which are displaceable substantially radially to the transfer wheel, wherein retaining clips arranged at the radially outwardly positioned support arm ends can be adjusted in the tangential direction about a rotational axis, wherein this rotational axis is arranged parallel to the central rotational axis of the transfer wheel.
A histochemical method of classifying a tumor on the basis of PD-L1 expression, the method comprising: contacting a tissue sample from the tumor with an antibody specific for human PD-L1 or an antigen-binding fragment thereof in a manner that deposits a stain on the tumor sample in proximity to areas of the tumor sample to which the antibody binds, wherein the antibody comprises a heavy chain CDR1 comprising SEQ ID NO: 1, a heavy chain CDR2 comprising SEQ ID NO: 2, a heavy chain CDR3 comprising SEQ ID NO: 3, a light chain CDR1 comprising SEQ ID NO: 4, a light chain CDR2 comprising SEQ ID NO: 5, a light chain CDR3 comprising SEQ ID NO: 6; quantitating a percentage of tumor cells having membrane-staining at any intensity above background; and scoring the tumor for PD-L1 expression, wherein the tumor is scored as PD-L1 positive if the percentage of tumor cells having membrane-staining at any intensity above background exceeds a predetermined cutoff that correlates with a likelihood that the tumor will respond to a PD-1 axis binding therapeutic agent, and wherein the cutoff is 25% or more of tumor cells having membrane-staining at any intensity above background and the scoring does not include quantitating anti-PD-Ll stained immune cells. contacting a tissue sample from the tumor with an antibody specific for human PD-L1 or an antigen-binding fragment thereof in a manner that deposits a stain on the tumor sample in proximity to areas of the tumor sample to which the antibody binds, wherein the antibody comprises a heavy chain CDR1 comprising SEQ ID NO: 1, a heavy chain CDR2 comprising SEQ ID NO: 2, a heavy chain CDR3 comprising SEQ ID NO: 3, a light chain CDR1 comprising SEQ ID NO: 4, a light chain CDR2 comprising SEQ ID NO: 5, a light chain CDR3 comprising SEQ ID NO: 6; quantitating a percentage of tumor cells having membrane-staining at any intensity above background; and scoring the tumor for PD-L1 expression, wherein the tumor is scored as PD-L1 positive if the percentage of tumor cells having membrane-staining at any intensity above background exceeds a predetermined cutoff that correlates with a likelihood that the tumor will respond to a PD-1 axis binding therapeutic agent, and wherein the cutoff is 25% or more of tumor cells having membrane-staining at any intensity above background and the scoring does not include quantitating anti-PD-Ll stained immune cells.
A pacifier comprising a nipple and a shield made of an elastic material, the shield having two stable mechanical states, in a first state the shield serving the purpose of a shield and in a second state the shield serving the purpose of a nipple cover, wherein the shield is arranged such that, upon impact to the shield, tension built up in the elastic material of shield transfers the shield from the first state to the second state.
An electropolishing or electroplating system comprising: an inner tank (160,460) configured to hold electrolytic fluid (170,470), the inner tank comprising a conductive plate (180a-c,480a-d); a system drive (192,492) configured to move a conveyor belt (190,490) from a first roller (105,200a,400a,405) located outside of the inner tank (160,460), around at least one second roller (200b,200c,400b,400c) within the inner tank (160,460), and onto a third roller (195,200d,400d,495), the conveyor belt (190,490) comprising a continuous assembly of interconnected component parts; and a tension device (102,402) connected to the first roller (105,200a,400a,405) and configured to actively resist movement of the conveyor belt (190,490) between the first roller (105,200a,400a,405) and the third roller (195,200d,400d,495) to maintain tension in the conveyor belt (190,490) and physical contact between the interconnected component parts, wherein the interconnected component parts turn with respect to one another as the conveyor belt (190,490) passes around the at least one second roller (200b,200c,400b,400c) within the inner tank (160,460) to expose previously covered portions of the interconnected component parts to the electrolytic fluid (170,470) and the conductive plate (180a-c,480a-d). an inner tank (160,460) configured to hold electrolytic fluid (170,470), the inner tank comprising a conductive plate (180a-c,480a-d); a system drive (192,492) configured to move a conveyor belt (190,490) from a first roller (105,200a,400a,405) located outside of the inner tank (160,460), around at least one second roller (200b,200c,400b,400c) within the inner tank (160,460), and onto a third roller (195,200d,400d,495), the conveyor belt (190,490) comprising a continuous assembly of interconnected component parts; and a tension device (102,402) connected to the first roller (105,200a,400a,405) and configured to actively resist movement of the conveyor belt (190,490) between the first roller (105,200a,400a,405) and the third roller (195,200d,400d,495) to maintain tension in the conveyor belt (190,490) and physical contact between the interconnected component parts, wherein the interconnected component parts turn with respect to one another as the conveyor belt (190,490) passes around the at least one second roller (200b,200c,400b,400c) within the inner tank (160,460) to expose previously covered portions of the interconnected component parts to the electrolytic fluid (170,470) and the conductive plate (180a-c,480a-d).
A valve prosthesis, comprising: a support frame radially expandable between a compact condition and an expanded condition, said support frame having an outer surface and defining a central orifice about an axis along an inflow-outflow direction; a plurality of flexible leaflets attached to the support frame to provide a one-way valve in the orifice when the support frame is in its expanded condition; and at least one valve clasper, wherein the at least one valve clasper and the support frame are movably connected such that during delivery and deployment of the valve prosthesis to a native valve the valve clasper is longitudinally moveable along the axis relative to the support frame from an engagement position in which the support frame is in the compact condition and the support frame and valve clasper are serially positioned so as to be off-set along said axis, and a nesting position where the at least one valve clasper is in a nested or concentric arrangement with the support frame, and longitudinal movement of the valve clasper is restricted when the support frame is in the expanded condition; and further wherein (i) in the engagement position, portions of the at least one valve clasper are radially displaceable from the support frame for contacting a floor of the native valve sinus, and (ii) when deployed, in the expanded condition tissue of the native valve is sandwiched between the support frame and the at least one valve clasper; characterised in that the number of valve claspers equals the number of native leaflets in the native valve to be treated. a support frame radially expandable between a compact condition and an expanded condition, said support frame having an outer surface and defining a central orifice about an axis along an inflow-outflow direction; a plurality of flexible leaflets attached to the support frame to provide a one-way valve in the orifice when the support frame is in its expanded condition; and at least one valve clasper, wherein the at least one valve clasper and the support frame are movably connected such that during delivery and deployment of the valve prosthesis to a native valve the valve clasper is longitudinally moveable along the axis relative to the support frame from an engagement position in which the support frame is in the compact condition and the support frame and valve clasper are serially positioned so as to be off-set along said axis, and a nesting position where the at least one valve clasper is in a nested or concentric arrangement with the support frame, and longitudinal movement of the valve clasper is restricted when the support frame is in the expanded condition; and further wherein (i) in the engagement position, portions of the at least one valve clasper are radially displaceable from the support frame for contacting a floor of the native valve sinus, and (ii) when deployed, in the expanded condition tissue of the native valve is sandwiched between the support frame and the at least one valve clasper; characterised in that the number of valve claspers equals the number of native leaflets in the native valve to be treated.
A method for determining a fetal nucleic acid concentration in maternal blood, comprising: step 1 of determining, by a processor, first genotype information based on alignment of sequencing data with at least a part of a reference genome, wherein the sequencing data are derived from a nucleic acid sample of the maternal blood; step 2 of correcting, by the processor, the first genotype information based on reference data by using a linkage disequilibrium relationship, to obtain second genotype information; and step 3 of determining, by the processor, the fetal nucleic acid concentration based on a difference between the first genotype information and the second genotype information. step 1 of determining, by a processor, first genotype information based on alignment of sequencing data with at least a part of a reference genome, wherein the sequencing data are derived from a nucleic acid sample of the maternal blood; step 2 of correcting, by the processor, the first genotype information based on reference data by using a linkage disequilibrium relationship, to obtain second genotype information; and step 3 of determining, by the processor, the fetal nucleic acid concentration based on a difference between the first genotype information and the second genotype information.
Core Network for data transmission in an Evolved Packet System, the Core Network comprising one or more node(s) serving as a Home Location Register according to a GSM/UMTS mobile communication network standard, the Core Network further comprising a node serving as a Home Subscriber Server according to 3GPP standards, and the Core Network further comprising an Interworking Function for the handling of messages exchanged between a signalling layer of the Core Network on the one hand and the node(s) serving as the Home Location Register as well as the node(s) serving as the Home Subscriber Server on the other hand, wherein the Core Network is arranged such that for an exchange of information between the signalling layer on the one hand, and the Interworking Function on the other hand, an Intelligent Network or an Advanced Intelligent Network is used, characterized in that the Interworking Function is arranged such that, in view of a specific request from the signalling layer regarding a specific User Equipment, in case that the specific User Equipmentis related or potentially related to a plurality of nodes serving as the Home Location Register and/or serving as the Home Subscriber Server, -- the specific request is multiplied by the Interworking Function and sent to the plurality of nodes serving as the Home Location Register and/or serving as the Home Subscriber Server, respectively, and -- responses of the plurality of nodes serving as the Home Location Register and/or serving as the Home Subscriber Server are consolidated and the specific request answered to the signalling layer by means of a feedback communication, wherein the specific request is preferably an ATI request, preferably regarding the location of the User Equipment. -- the specific request is multiplied by the Interworking Function and sent to the plurality of nodes serving as the Home Location Register and/or serving as the Home Subscriber Server, respectively, and -- responses of the plurality of nodes serving as the Home Location Register and/or serving as the Home Subscriber Server are consolidated and the specific request answered to the signalling layer by means of a feedback communication, wherein the specific request is preferably an ATI request, preferably regarding the location of the User Equipment.
End-piece for a motor vehicle glass wiper including at least one flexible support and a wiper blade intended to be pressed against the glass, the end-piece including a housing adapted to receive an end portion of the flexible support, the end-piece including means for locking the end portion of the flexible support in an engaged position inside the housing, the locking means including at least one tongue, characterized in that the locking means include at least one cavity that is delimited by at least a first lateral wall, a second lateral wall and the tongue.
A compound of Formula or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from the group consisting of -OR a and a 5-6 membered heteroaryl; R 2 and R 3 are each independently selected from the group consisting of H, C 1-6 alkyl, -OR b, -C 0-6 alkylene-SO 2 R 4, and -C OR 5; R 4 is -OR 5, C 1-6 alkyl, C 1-6 haloalkyl, heteroC 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-8 cycloalkylC 0-6 alkyl; R 5 is H or C 1-6 alkyl; R a is selected from the group consisting of H, -P (R b) 2, -C R c, -C OR c, C 1-6 alkyl, and C 1-6 hydroxyalkyl; each R b is independently selected from the group consisting of H and C 1-6 alkyl; and each R c is independently selected from the group consisting of H, C 1-6 alkyl, and C 1-6 hydroxyalkyl. R 1 is selected from the group consisting of -OR a and a 5-6 membered heteroaryl; R 2 and R 3 are each independently selected from the group consisting of H, C 1-6 alkyl, -OR b, -C 0-6 alkylene-SO 2 R 4, and -C OR 5; R 4 is -OR 5, C 1-6 alkyl, C 1-6 haloalkyl, heteroC 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-8 cycloalkylC 0-6 alkyl; R 5 is H or C 1-6 alkyl; R a is selected from the group consisting of H, -P (R b) 2, -C R c, -C OR c, C 1-6 alkyl, and C 1-6 hydroxyalkyl; each R b is independently selected from the group consisting of H and C 1-6 alkyl; and each R c is independently selected from the group consisting of H, C 1-6 alkyl, and C 1-6 hydroxyalkyl.
An aerosol generating product with flavoring in supporting section, wherein, the product comprises a smoking core-material section, a supporting section, a permeable hollow section and a filtering section arranged in turn; the supporting section is provided with a hollow airflow channel and a plurality of flavoring channels inside; the plurality of flavoring channels surround the outer side of the hollow airflow channel, and one end of the plurality of flavoring channels that is close to the smoking core-material section is closed, and the other end that is close to the permeable hollow section is open; a flavoring capsule is provided in at least part of the flavoring channel, and the flavoring capsule is close to one side of the smoking core-material section; an air-vent hole that axially penetrates the permeable hollow section is provided on the permeable hollow section. the supporting section is provided with a hollow airflow channel and a plurality of flavoring channels inside; the plurality of flavoring channels surround the outer side of the hollow airflow channel, and one end of the plurality of flavoring channels that is close to the smoking core-material section is closed, and the other end that is close to the permeable hollow section is open; a flavoring capsule is provided in at least part of the flavoring channel, and the flavoring capsule is close to one side of the smoking core-material section; an air-vent hole that axially penetrates the permeable hollow section is provided on the permeable hollow section.
A ply-twisted yarn suitable for use in a flame-retardant, cut-resistant fabric, the ply-twisted yarn comprising: (a) at least one first yarn comprising at least 50 weight percent heat-resistant polymeric fiber, wherein at least 30 weight percent of the polymeric fiber present in the at least one first yarn is cut-resistant heat-resistant polymeric fiber having a cut resistance of 4.9 N (500 grams force) or higher per ASTM F2992-15; and (b) at least one second yarn having a sheath/core construction with a core comprising at least one continuous elastomeric filament, the second yarn being free of inorganic fibers; characterized in that the sheath of the second yarn comprises halogenated self-extinguishing staple fibers, 60 to 95 weight percent of the at least one second yarn is halogenated self-extinguishing fiber, and the halogenated self-extinguishing fiber is in contact with the at least one continuous elastomeric filament. (a) at least one first yarn comprising at least 50 weight percent heat-resistant polymeric fiber, wherein at least 30 weight percent of the polymeric fiber present in the at least one first yarn is cut-resistant heat-resistant polymeric fiber having a cut resistance of 4.9 N (500 grams force) or higher per ASTM F2992-15; and (b) at least one second yarn having a sheath/core construction with a core comprising at least one continuous elastomeric filament, the second yarn being free of inorganic fibers;
A liquid crystal display device, comprising: a substrate; a first gate line disposed on the substrate; a first data line disposed on the substrate and crossing the first gate line; a first subpixel unit including a first switching element which includes a control electrode connected with the first gate line and a first electrode connected with the first data line, and a first subpixel electrode connected with a second electrode of the first switching element; a second subpixel unit including a second switching element which includes a control electrode connected with the first gate line and a first electrode connected with the first data line, a second subpixel electrode connected with a second electrode of the second switching element, and a third switching element including a control electrode connected with the first gate line; and characterized by a storage wiring including a first storage line, at least a part thereof overlapping the first subpixel electrode, and a second storage line, at least a part thereof overlapping the second subpixel electrode, wherein a first electrode of the third switching element is disposed on a different layer from that on which the first and second storage lines (RL1, RL2) are disposed and is connected with both the first and second storage lines (RL1, RL2), and a second electrode of the third switching element is connected with the second subpixel electrode. a substrate; a first gate line disposed on the substrate; a first data line disposed on the substrate and crossing the first gate line; a first subpixel unit including a first switching element which includes a control electrode connected with the first gate line and a first electrode connected with the first data line, and a first subpixel electrode connected with a second electrode of the first switching element; a second subpixel unit including a second switching element which includes a control electrode connected with the first gate line and a first electrode connected with the first data line, a second subpixel electrode connected with a second electrode of the second switching element, and a third switching element including a control electrode connected with the first gate line; and characterized by a storage wiring including a first storage line, at least a part thereof overlapping the first subpixel electrode, and a second storage line, at least a part thereof overlapping the second subpixel electrode, wherein a first electrode of the third switching element is disposed on a different layer from that on which the first and second storage lines (RL1, RL2) are disposed and is connected with both the first and second storage lines (RL1, RL2), and a second electrode of the third switching element is connected with the second subpixel electrode.