A method of performing a measurement of a processed biological sample using a cartridge (100, 200, 2100) formed from a carrier structure and a cover, wherein the cartridge is operable for being spun around a rotational axis, wherein the cartridge further comprises at least one container with at least one fluid reservoir (108, 202) containing at least one fluid (110, 204), wherein the cartridge comprises a cavity (104, 104') for each of the at least one container, wherein the at least one cavity is formed from the carrier structure and the cover, wherein the at least one container is configured to rotate about the rotational axis of the cartridge within the cavity, wherein the at least one container is configured to rotate relative to the cartridge, wherein each of the at least one fluid reservoir comprises a pierceable seal, wherein the cavity comprises at least one piercing structure for each of the at least one fluid reservoir, wherein the at least one piercing structure is configured to open the seal by piercing the pierceable seal when the at least one container is rotated relative to the cartridge, wherein the at least one container comprises a first frictional element and the cavity comprises a second frictional element, wherein the first frictional element mates with the second frictional element, wherein the first frictional element and the second frictional element are configured for causing friction between the cavity and the at least one container, wherein the at least one container comprises a first engaging surface operable for mating with a second engaging surface of a rotational actuator operable for applying torque to the at least one container, wherein the cartridge comprises a fluidic structure (120, 2116, 2117, 2118, 2120, 2121, 2122, 2123, 2124, 2125, 2130, 2131, 2132, 2133, 2134, 2135) for processing a biological sample into the processed biological sample, wherein the fluidic structure is formed from the carrier structure and the cover, wherein the cartridge comprises a duct between the cavity and the fluidic structure, wherein the duct is formed from the carrier structure and the cover, wherein the fluidic structure is located within the carrier structure, wherein the fluidic structure comprises an measurement structure (2119, 2210) for enabling the measurement of the processed biological sample, wherein the fluidic structure is configured for receiving the biological sample, wherein the method comprises the steps of: - placing the biological sample into the fluidic structure; - applying the torque to the at least one container using the rotational actuator to overcome the friction between the cavity and the at least one container and rotate the at least one container relative to the cartridge around the rotational axis of the cartridge to open the pierceable seal, wherein rotating the at least one container relative to the cartridge causes the at least one piercing structure to open the seal by piercing the pierceable seal; - controlling the rotational rate of the cartridge to process the biological sample into the processed biological sample using the fluidic structure; - controlling the rotational rate of the cartridge to force the at least one fluid through the duct and through at least a portion of the fluidic structure, wherein the friction between the cavity and the at least one container causes the at least one container to rotate around the rotational axis of the axis at the same rate as the cartridge; - performing the measurement through the measurement structure using a measurement system. - placing the biological sample into the fluidic structure; - applying the torque to the at least one container using the rotational actuator to overcome the friction between the cavity and the at least one container and rotate the at least one container relative to the cartridge around the rotational axis of the cartridge to open the pierceable seal, wherein rotating the at least one container relative to the cartridge causes the at least one piercing structure to open the seal by piercing the pierceable seal; - controlling the rotational rate of the cartridge to process the biological sample into the processed biological sample using the fluidic structure; - controlling the rotational rate of the cartridge to force the at least one fluid through the duct and through at least a portion of the fluidic structure, wherein the friction between the cavity and the at least one container causes the at least one container to rotate around the rotational axis of the axis at the same rate as the cartridge; - performing the measurement through the measurement structure using a measurement system.