A compound of formula wherein R 1 is optionally substituted imidazolyl, optionally substituted pyrazolyl, optionally substituted triazolyl or optionally substituted pyrrolidinyl; R 2 is optionally substituted C 6 -C 12 -aryl, optionally substituted M 3 -M 12 -heterocyclyl, optionally substituted C 3 -C 12 -cycloalkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkoxy-C 11 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl or halogenated C 1 -C 12 -alkyl; R 3a is optionally substituted C 6 -C 12 -aryl, optionally substituted M 3 -M 12 -heterocyclyl, optionally substituted C 3 -C 12 -cycloalkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy or halogenated C 1 -C 12 -alkyl; R 3b is hydrogen or C 1 -C 6 -alkyl; R 4a and R 4b are independently hydrogen or C 1 -C 4 -alkyl; wherein at least one of R 2 and R 3a is optionally substituted C 6 -C 12 -aryl or optionally substituted M 3 -M 12 -heterocyclyl; and wherein the term "substituted" means that a radical is substituted with 1, 2 or 3 substituents which are independently selected from the group consisting of halogen, cyano (-CN), C 1 -C 4 -alkyl, halogenated-C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, hydroxy-(halogenated C 1 -C 4 -alkyl), C 1 -C 4 -alkylamino, di-C 1 -C 4 -alkylamino, C 1 -C 6 -alkylsulfonylamino, amino-C 1 -C 4 -alkyl, C 1 -C 4 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 4 -alkylamino-C 1 -C 4 -alkyl, C 1 -C 4 -alkylcarbonylamino, C 1 -C 4 -alkylaminocarbonyl, (di-C 1 -C 4 -alkylamino)carbonyl, C 1 -C 4 -alkylamino-C 1 -C 4 -alkoxy, di-C 1 -C 4 -alkylamino-C 1 -C 4 -alkoxy, C 1 -C 4 -alkylcarbonyl, halogenated C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylsulfonyl, C 1 -C 4 -alkylaminosulfonyl, di-C 1 -C 4 -alkylaminosulfonyl, C 1 -C 4 -alkoxy, halogenated-C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxycarbonyl, carboxy-C 1 -C 4 -alkoxy, C 2 -C 4 -alkenyl, -CO 2 H, SH, aminosulfonyl, amino (-NH 2), aminocarbonyl, oxo (=O), hydroxy (-OH), C 3 -C 2 -cycloalkyl, C 3 -C 12 -cycloalkoxy, C 3 -C 12 -cycloalykyl-C 1 -C 4 -alkoxy, C 6 -C 12 -aryl, C 6 -C 12 -aryloxy, C 6 -C 12 -arylsulfonyl, C 6 -C 12 -aryl-C 1 -C 4 -alkyl, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 6 -C 12 -aryl-C 1 -C 4 -alkylamino, C 6 -C 2 -arylaminocarbonyl, C 6 -C 12 -arylcarbonylamino, C 6 -C 12 -arylaminosulfonyl, C 6 -C 12 -arylsulfonylamino, M 3 -M 12 -heterocyclyl, M 3 -M 12 -heterocycloxy, M 3 -M 12 -heterocyclyl-C 1 -C 4 -alkyl, M 3 -M 12 -heterocyclyl-C 1 -C 4 -alkoxy, M 3 -M 12 -heterocyclylaminocarbonyl, M 3 -M 12 -heterocyclylcarbonylamino, M 3 -M 12 -heterocyclylaminosulfonyl, and M 3 -M 12 -heterocyclylsulfonylamino, wherein aryl and heterocyclyl may be unsubstituted or substituted with 1, 2 or 3 substituents independently selected from the group consisting of halogen, C 1 -C 4 -alkyl, halogenated C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halogenated C 1 -C 4 -alkoxy, or a physiologically tolerated salt thereof. R 1 is optionally substituted imidazolyl, optionally substituted pyrazolyl, optionally substituted triazolyl or optionally substituted pyrrolidinyl; R 2 is optionally substituted C 6 -C 12 -aryl, optionally substituted M 3 -M 12 -heterocyclyl, optionally substituted C 3 -C 12 -cycloalkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkoxy-C 11 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl or halogenated C 1 -C 12 -alkyl; R 3a is optionally substituted C 6 -C 12 -aryl, optionally substituted M 3 -M 12 -heterocyclyl, optionally substituted C 3 -C 12 -cycloalkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkyl, (optionally substituted C 6 -C 12 -aryl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted M 3 -M 12 -heterocyclyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, (optionally substituted C 3 -C 12 -cycloalkyl)-C 1 -C 12 -alkoxy-C 1 -C 12 -alkyl, C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy or halogenated C 1 -C 12 -alkyl; R 3b is hydrogen or C 1 -C 6 -alkyl; R 4a and R 4b are independently hydrogen or C 1 -C 4 -alkyl;