An orthopedic device, comprising: a body having a monolithic structure and arranged to form a closed circumference in a secured configuration, the body having a predetermined shape in an unsecured configuration; wherein the body is formed continuously without interruption from at least one polymeric material, the body defining a band disposed about a periphery of the body, the band enclosing at least one fenestration region (108, 110) defining at least two fenestrations (140, 142, 144) formed by the body and arranged in a predetermined pattern the body defining at least one rib extending from the band and adjacent to the at least one fenestration region (108, 110), the at least one rib exhibiting greater rigidity than the at least one fenestration region (108, 110), the body defining a thumb column sized and configured for supporting a thumb; wherein the band and the at least one rib (112, 113) combine to form a frame that extends around the at least one fenestration region (108, 110), such that the frame is substantially more rigid than the at least one fenestration region (108, 110), the frame having a varying width about the periphery of the body; wherein the body defines an opening bordered by the at least one rib and the band, and formed along a wall of the body, the opening being greater in size than the at least two fenestrations (140, 142, 144) of the at least two fenestration regions (108, 110), the opening located within a length of the thumb column, the thumb column defines an outlet from which a portion of a distal phalange of the thumb extends, the orthopedic device being characterised by the thumb Column defining a lip extending about the opening and having a greater thickness than the at least one rib and/or band. a body having a monolithic structure and arranged to form a closed circumference in a secured configuration, the body having a predetermined shape in an unsecured configuration; wherein the body is formed continuously without interruption from at least one polymeric material, the body defining a band disposed about a periphery of the body, the band enclosing at least one fenestration region (108, 110) defining at least two fenestrations (140, 142, 144) formed by the body and arranged in a predetermined pattern the body defining at least one rib extending from the band and adjacent to the at least one fenestration region (108, 110), the at least one rib exhibiting greater rigidity than the at least one fenestration region (108, 110), the body defining a thumb column sized and configured for supporting a thumb; wherein the band and the at least one rib (112, 113) combine to form a frame that extends around the at least one fenestration region (108, 110), such that the frame is substantially more rigid than the at least one fenestration region (108, 110), the frame having a varying width about the periphery of the body; wherein the body defines an opening bordered by the at least one rib and the band, and formed along a wall of the body, the opening being greater in size than the at least two fenestrations (140, 142, 144) of the at least two fenestration regions (108, 110), the opening located within a length of the thumb column, the thumb column defines an outlet from which a portion of a distal phalange of the thumb extends, the orthopedic device being characterised by the thumb Column defining a lip extending about the opening and having a greater thickness than the at least one rib and/or band.