mhurhangee/ep-ind-claims huggingface dataset:
A humanized anti-NGF antibody or a fragment thereof which maintains binding activity to NGF, wherein the humanized anti-NGF antibody comprises: (a) a heavy chain variable region having a first CDR comprising the amino acid sequence GFSLTNNNVN, a second CDR comprising the amino acid sequence GVWAGGATDYNSALKS, and a third CDR comprising the amino acid sequence DGGYSSSTLYAMDA; and (b) a light chain variable region having a first CDR comprising the amino acid sequence RASEDIYNALA, a second CDR comprising the amino acid sequence HT, and a third CDR comprising the amino acid sequence QHYFHYPRT; wherein the framework of the heavy chain variable region is at least 85% identical to the framework of SEQ ID NO: 19; and the framework of the light chain variable region is at least 85% identical to the framework of SEQ ID NO: 20; and wherein the amino acid of the heavy chain variable region that corresponds to position 67 of SEQ ID NO: 19 is Phe, and wherein the amino acid of the heavy chain variable region that corresponds to position 71 of SEQ ID NO: 19 is Arg; and wherein the amino acid of the light chain variable region that corresponds to position 46 of SEQ ID NO: 20 is Leu, wherein the amino acid of the light chain variable region that corresponds to position 50 of SEQ ID NO: 20 is Asn, wherein the amino acid of the light chain variable region that corresponds to position 51 of SEQ ID NO: 20 is Thr, wherein the amino acid of the light chain variable region that corresponds to position 52 of SEQ ID NO: 20 is Asp, wherein the amino acid of the light chain variable region that corresponds to position 53 of SEQ ID NO: 20 is Thr, wherein the amino acid of the light chain variable region that corresponds to position 54 of SEQ ID NO: 20 is Leu, and wherein the amino acid of the light chain variable region that corresponds to position 87 of SEQ ID NO: 20 is Phe. (a) a heavy chain variable region having a first CDR comprising the amino acid sequence GFSLTNNNVN, a second CDR comprising the amino acid sequence GVWAGGATDYNSALKS, and a third CDR comprising the amino acid sequence DGGYSSSTLYAMDA; and (b) a light chain variable region having a first CDR comprising the amino acid sequence RASEDIYNALA, a second CDR comprising the amino acid sequence HT, and a third CDR comprising the amino acid sequence QHYFHYPRT;
A method for preparing a retort ink, comprising: selecting a polyurethane binder on the basis of the polyurethane having an enthalpic relaxation endotherm of 0.6 J/g or less after 3 days of aging at ambient temperature as measured using differential scanning calorimetry within a temperature range of -60°C to 180°C using open aluminum pans in an inert environment and a heating ramp of 10°C per minute; and combining the polyurethane binder, a colorant and a carrier to produce a retort ink. selecting a polyurethane binder on the basis of the polyurethane having an enthalpic relaxation endotherm of 0.6 J/g or less after 3 days of aging at ambient temperature as measured using differential scanning calorimetry within a temperature range of -60°C to 180°C using open aluminum pans in an inert environment and a heating ramp of 10°C per minute; and combining the polyurethane binder, a colorant and a carrier to produce a retort ink.
A surgical stapling instrument, comprising: a handle comprising a trigger; a shaft extending from said handle; a firing member operably coupled with said trigger such that a firing motion can be transferred from said trigger to said firing member to move said firing member along a firing path; a plurality of staple cartridges positioned within said shaft, wherein each said staple cartridge comprises: a cartridge body comprising a plurality of apertures; and a plurality of staples each comprising a staple leg positioned in one of said apertures, wherein said staple legs are slidable within said apertures; a first jaw comprising a channel configured to receive said staple cartridges; a second jaw comprising an anvil, wherein said staple legs are configured to contact said anvil; a biasing member configured to sequentially advance said staple cartridges into a staging position, wherein said plurality of staple cartridges comprises a distal staple cartridge positioned in said staging position and a proximal staple cartridge, and wherein said biasing member is configured to directly engage said proximal staple cartridge, said instrument being characterized in that it comprises a cartridge driver configured to sequentially advance said staple cartridges into said channel from said staging position, wherein said cartridge driver is configured to directly engage said distal staple cartridge and advance said distal staple cartridge into said channel. a handle comprising a trigger; a shaft extending from said handle; a firing member operably coupled with said trigger such that a firing motion can be transferred from said trigger to said firing member to move said firing member along a firing path; a plurality of staple cartridges positioned within said shaft, wherein each said staple cartridge comprises: a cartridge body comprising a plurality of apertures; and a plurality of staples each comprising a staple leg positioned in one of said apertures, wherein said staple legs are slidable within said apertures; a cartridge body comprising a plurality of apertures; and a plurality of staples each comprising a staple leg positioned in one of said apertures, wherein said staple legs are slidable within said apertures; a first jaw comprising a channel configured to receive said staple cartridges; a second jaw comprising an anvil, wherein said staple legs are configured to contact said anvil; a biasing member configured to sequentially advance said staple cartridges into a staging position, a biasing member configured to sequentially advance said staple cartridges into a staging position,
A spinning cycle control method of a laundry machine comprising a drum and a balancer (70; 310; 330) having a movable gravity center and being mounted to the drum, the control method comprising: implementing a first balancing after a speed of a drum passes a transient region of the laundry machine and before the drum enters into an accelerating step; decreasing the speed of a drum when vibration of the drum sensed in the accelerating step is a predetermined value or more; and rotating the drum at a constant speed for a predetermined time period to implement a second balancing, wherein the transient region is a predetermined RPM band including at least one resonance frequency which generates resonance according to the system of the laundry machine. implementing a first balancing after a speed of a drum passes a transient region of the laundry machine and before the drum enters into an accelerating step; decreasing the speed of a drum when vibration of the drum sensed in the accelerating step is a predetermined value or more; and rotating the drum at a constant speed for a predetermined time period to implement a second balancing, wherein the transient region is a predetermined RPM band including at least one resonance frequency which generates resonance according to the system of the laundry machine.
A method for controlling a water jet propulsion device for the propulsion of a marine vessel, the water jet propulsion device comprising - a conduit extending between an inlet and an outlet, - an impeller in the conduit, and - a mechanical power provider arranged to deliver power to the impeller, - the method comprising receiving a plurality of thrust commands, and controlling a thrust level of the water jet propulsion device in dependence of the thrust commands, wherein controlling the thrust level comprises adjusting a position of a deflector arranged to deflect water flowing out of the outlet, - characterised by - coordinating the adjustment of the position of the deflector with a level of engagement of a clutch, arranged to adjust the delivery of power from the power provider to the impeller, so that the thrust level is substantially continuous in a thrust command domain. - a conduit extending between an inlet and an outlet, - an impeller in the conduit, and - a mechanical power provider arranged to deliver power to the impeller, - the method comprising receiving a plurality of thrust commands, and controlling a thrust level of the water jet propulsion device in dependence of the thrust commands, wherein controlling the thrust level comprises adjusting a position of a deflector arranged to deflect water flowing out of the outlet, - characterised by - coordinating the adjustment of the position of the deflector with a level of engagement of a clutch, arranged to adjust the delivery of power from the power provider to the impeller, so that the thrust level is substantially continuous in a thrust command domain.
Method for determining at least one optimal insertion segment (810a, 810b, 810c, 810d) in a blood vessel of a patient for inserting a needle into said blood vessel, said segment (810a, 810b, 810c, 810d) being representative of an insertion point (820a, 820b, 820c, 820d) in a part of the body of the patient, an insertion direction and a maximum insertion length, comprising the following steps: - a step of illuminating the part of the body of the patient with near-infrared illumination, - a step of acquiring near-infrared images of the part of the body of the patient with at least one camera, - a step of pre-processing the acquired images to obtain an image of the blood vessels visible on the surface of the part of the body of the patient, referred to as pre-processed image, - a step of applying a linear structure detection filter to said pre-processed image to obtain an image, referred to as vascular profile map, which identifies the blood vessels visible on the surface of the part of the body of the patient, - a step of binarizing the vascular profile map, - a step of skeletonising the blood vessels on the binarized vascular profile map, configured to obtain, for each blood vessel, a skeleton of said blood vessel, - a step of defining insertion segments from said skeletons of the blood vessels, for each blood vessel, - a step of classifying the insertion segments according to predetermined classification parameters, so as to identify one or more optimal insertion segments. - a step of illuminating the part of the body of the patient with near-infrared illumination, - a step of acquiring near-infrared images of the part of the body of the patient with at least one camera, - a step of pre-processing the acquired images to obtain an image of the blood vessels visible on the surface of the part of the body of the patient, referred to as pre-processed image, - a step of applying a linear structure detection filter to said pre-processed image to obtain an image, referred to as vascular profile map, which identifies the blood vessels visible on the surface of the part of the body of the patient, - a step of binarizing the vascular profile map, - a step of skeletonising the blood vessels on the binarized vascular profile map, configured to obtain, for each blood vessel, a skeleton of said blood vessel, - a step of defining insertion segments from said skeletons of the blood vessels, for each blood vessel, - a step of classifying the insertion segments according to predetermined classification parameters, so as to identify one or more optimal insertion segments.
A method implemented in a base station used in a wireless communication network, the method including: providing, to a radio device, a first control message on a first channel, the first control message indicating: a presence of a second control message on a second channel; and a coverage enhancement configuration of the second control message; and providing, to the radio device, the second control message on the second channel according to the coverage enhancement configuration, and providing, to the radio device, repetitions of the first message in a plurality of distinguishable control regions, wherein the coverage enhancement configuration defines a number of repetitions of the second control message in a repetition region for repeating the second control message on the second channel, the first message is provided on a physical downlink control indicator channel, the second message is provided on a physical downlink control channel, and the radio device comprises a Machine-Type Communication, MTC, device, wherein, the plurality of the distinguishable control regions comprise control regions of consecutive subframes within a radio frame immediately preceding the radio frame having the second control message, and wherein the first and second channels are MTC specific control channels. providing, to a radio device, a first control message on a first channel, the first control message indicating: a presence of a second control message on a second channel; and a coverage enhancement configuration of the second control message; and a presence of a second control message on a second channel; and a coverage enhancement configuration of the second control message; and providing, to the radio device, the second control message on the second channel according to the coverage enhancement configuration, and providing, to the radio device, repetitions of the first message in a plurality of distinguishable control regions, wherein the coverage enhancement configuration defines a number of repetitions of the second control message in a repetition region for repeating the second control message on the second channel, the first message is provided on a physical downlink control indicator channel, the second message is provided on a physical downlink control channel, and the radio device comprises a Machine-Type Communication, MTC, device, wherein, the plurality of the distinguishable control regions comprise control regions of consecutive subframes within a radio frame immediately preceding the radio frame having the second control message, and wherein the first and second channels are MTC specific control channels. wherein the first and second channels are MTC specific control channels.
A corneal contact lens for orthokeratology comprising: a central zone having a first curvature; at least a first annular zone located concentrically around said central zone and having a second curvature, and at least one peripheral annular zone outside the first annular zone having a third curvature or zero curvature, said first annular zone and the at least one peripheral annular zone being continuous with said central zone, wherein the first and second curvatures are generated from first and second origins of curvature respectively, and the lens including a central axis defined by an apex of the central zone and the first origin of said first curvature and wherein the second origin of said second curvature is not located on said central axis a central zone having a first curvature; at least a first annular zone located concentrically around said central zone and having a second curvature, and at least one peripheral annular zone outside the first annular zone having a third curvature or zero curvature, said first annular zone and the at least one peripheral annular zone being continuous with said central zone, wherein the first and second curvatures are generated from first and second origins of curvature respectively, and the lens including a central axis defined by an apex of the central zone and the first origin of said first curvature and wherein the second origin of said second curvature is not located on said central axis
Method for calibrating a rotary encoder for measuring a rotary angle position of a machine shaft, in particular an externally mounted absolute-value encoder, wherein the rotary encoder has at least one exciter unit which is rotationally fixedly connected to the machine shaft and by means of which at least one measuring point (61a, 61b, 61c, 61d) is defined to measure an actual rotary angle position, and a stationary sensor unit functionally interacting with the exciter unit, comprising the following steps: - setting the machine shaft in rotation at a predetermined rotational speed, - measuring a start measuring point by the sensor unit, - activating a timer module for incrementing a time value (t), - measuring at least one intermediate measuring point (61b, 61c) by the sensor unit, the intermediate measuring point (61b, 61c) being assigned a time value (t) that has been incremented at the measurement time, - storing the rotary angle position of the intermediate measuring point (61b, 61c) and the associated time value (t), - measuring an end measuring point by the sensor unit, - determining a time value (t) being incremented by the timer module and indicating a runtime for the rotary motion from the start measuring point to the end measuring point, - calculating at least one time-dependent reference rotary angle position assuming a constant rotary motion of the machine shaft from the start measuring point to the end measuring point, - calculating a deviation between the measured actual rotary angle position and the calculated reference rotary angle position for at least one time value (t) by a calculation module stored in the rotary encoder and - correcting the output signal of the rotary encoder by the calculated deviation. - setting the machine shaft in rotation at a predetermined rotational speed, - measuring a start measuring point by the sensor unit, - activating a timer module for incrementing a time value (t), - measuring at least one intermediate measuring point (61b, 61c) by the sensor unit, the intermediate measuring point (61b, 61c) being assigned a time value (t) that has been incremented at the measurement time, - storing the rotary angle position of the intermediate measuring point (61b, 61c) and the associated time value (t), - measuring an end measuring point by the sensor unit, - determining a time value (t) being incremented by the timer module and indicating a runtime for the rotary motion from the start measuring point to the end measuring point, - calculating at least one time-dependent reference rotary angle position assuming a constant rotary motion of the machine shaft from the start measuring point to the end measuring point, - calculating a deviation between the measured actual rotary angle position and the calculated reference rotary angle position for at least one time value (t) by a calculation module stored in the rotary encoder and - correcting the output signal of the rotary encoder by the calculated deviation.
A heat exchanger comprising: • a tank (10a, 10b) adapted to receive a first heat exchange fluid therein; • a plurality of spaced apart tubular elements defining a heat exchanger core, adapted to be in fluid communication with the tank (10a, 10b) and enable heat exchange between a first heat exchange fluid flowing there through and a second heat exchange fluid flowing around and across the tubular elements; • a plurality of fins arranged alternately with the tubular elements, the fins being adapted to promote heat exchange between the first heat exchange fluid and the second heat exchange fluid, the first and the last of the fins constituting respectively opposite lateral faces of the heat exchanger core; • a side cover adjacent to a lateral face of the core; wherein the side cover is adapted to cover the corresponding lateral face of the heat exchanger core and at least a portion of the heat exchanger core disposed between the tubular element proximal to the lateral face of the heat exchanger core and the corresponding side cover and in that the side cover comprises: ∘ a side panel complimentary to and aligned with respect to a corresponding lateral face of the heat exchanger core; and ∘ tabs configured on at least one of the opposite lateral sides of the side panel, the tabs being orthogonal to the side panel and adapted to cover at least a portion of the fins disposed between the tubular element proximal to the lateral face of the heat exchanger core and the corresponding side panel and wherein the tabs formed on extreme ends of the opposite sides of the side panel are abutting the respective tank (10a, 10b), and characterized in that the tank (10a,10b) is wider than the side cover, the side cover being wider than the heat exchanger core accommodating an insulating material between the side cover and the heat exchanger core. • a tank (10a, 10b) adapted to receive a first heat exchange fluid therein; • a plurality of spaced apart tubular elements defining a heat exchanger core, adapted to be in fluid communication with the tank (10a, 10b) and enable heat exchange between a first heat exchange fluid flowing there through and a second heat exchange fluid flowing around and across the tubular elements; • a plurality of fins arranged alternately with the tubular elements, the fins being adapted to promote heat exchange between the first heat exchange fluid and the second heat exchange fluid, the first and the last of the fins constituting respectively opposite lateral faces of the heat exchanger core; • a side cover adjacent to a lateral face of the core; ∘ a side panel complimentary to and aligned with respect to a corresponding lateral face of the heat exchanger core; and ∘ tabs configured on at least one of the opposite lateral sides of the side panel, the tabs being orthogonal to the side panel and adapted to cover at least a portion of the fins disposed between the tubular element proximal to the lateral face of the heat exchanger core and the corresponding side panel and wherein the tabs formed on extreme ends of the opposite sides of the side panel are abutting the respective tank (10a, 10b),
A cosmetic formulation selected from the group consisting of sunscreen compositions, comprising at least one UV filter selected from the group consisting of PABA, Camphor Benzalkonium Methosulfate, Homosalate, Benzophenone-3 (BENZ-3), Phenylbenzimidazole Sulfonic Acid (PBSA), Terephthalidene Dicamphor Sulfonic Acid, Butyl Methoxydibenzoylmethane (BMDBM), Benzylidene Camphor Sulfonic Acid, Octocrylene, Polyacrylamidomethyl Benzylidene Camphor, Ethylhexyl Methoxycinnamate (EMC, OMC), PEG-25 PABA (PEG-PABA), Isoamyl p-Methoxycinnamate, Ethylhexyl Triazone (OT, ET), Drometrizole Trisiloxane, Diethylhexyl Butamido Triazone, 4-Methyl-benzylidene Camphor, 3-Benzylidene Camphor, Ethylhexyl Salicylate (OS, ES), Ethylhexyl Dimethyl PABA (OD-PABA, ED-PABA), Benzophenone-4 (BENZ-4), Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Bisoctyltriazol, BOT), Bisimidazylate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Polysilicone 15, Diethylamino Hydroxybenzoyl Hexyl Benzoate, 2,4,6-Tris (biphenyl)-1,3,5-triazine, Methanone 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]] of CAS number 919803-06-8, 1,1-Di(carboxy-(2',2'-dimethyl-propyl))-4,4-diphenylbutadiene, Merocyanine derivatives, Benzylidene Malonate UVB filters, Titanium Dioxide and Zinc Oxide and at least one copolymer comprising a) 40 to 95% by weight of N-vinylpyrrolidone and b) 5 to 60% by weight of a hydrophobically modified acrylic ester derivative which is an acrylic acid ester or methacrylic acid ester of the formula I, in which R 1 is hydrogen or methyl and R 2 is C 14 to C 22 -alkyl, wherein the copolymers consist to more than 99% by weight of N-vinylpyrrolidone and the hydrophobically modified acrylic acid derivative. a) 40 to 95% by weight of N-vinylpyrrolidone and b) 5 to 60% by weight of a hydrophobically modified acrylic ester derivative which is an acrylic acid ester or methacrylic acid ester of the formula I, R 1 is hydrogen or methyl and R 2 is C 14 to C 22 -alkyl,
A MetAP2 inhibitor for use in a method of treating, reducing, or ameliorating a renal injury selected from the group consisting of an ischemic renal injury and an ischemic-reperfusion renal injury to a kidney, comprising administering an effective amount of MetAP2 inhibitor to a patient, wherein the MetAP2 inhibitor is 6- O -(4-dimethylaminoethoxy)cinnamoyl fumagillol or a pharmaceutically acceptable salt thereof.