A compound of formula: including a pharmaceutically acceptable salt, tautomer, stereoisomer or N -oxide derivative thereof, wherein: R 1 is H, OH or an optionally substituted alkyl group; R 2 is an optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C6 alkylcycloalkyl, optionally substituted C4-C6 aryl, optionally substituted C3-C6 heteroaryl, optionally substituted C4-C8 aryloxy, optionally substituted C7-C10 arylalkyl or optionally substituted C5-C10 heteroarylalkyl group; and Q is represented by formula: wherein: R 5a is H, halo, optionally substituted C1-C6 alkyl, or optionally substituted amino; R 5b is H, halo, optionally substituted C2-C6 alkynyl, benzyl, optionally monosubstituted C3-C6 heteroaryl, optionally substituted C3-C6 heterocycloalkyl, optionally substituted C1-C6 alkoxy, NR'R", or R a NR'R", wherein R a is C1-C6 alkyl or C2-C6 alkenyl; and wherein R' and R" are each independently selected from H, oxo-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, optionally substituted C1-C7 alkylamine, optionally substituted C2-C7 alkenylamine, optionally substituted C3-C10 heterocycloalkyl, optionally substituted C4-C10 aryl, optionally substituted C3-C10 heteroaryl, optionally substituted C5-C10 alkylaryl, optionally substituted C4-C10 alkylheterocycloalkyl, and C4-C6 alkylheteroaryl, or wherein R' and R" together form an optionally substituted C3-C8 heterocycloalkyl including the N to which they are attached, wherein for any of the functional groups for which one or more substituents are optional, the optional substituents are independently selected from OH, F, Cl, Br, I, CN, C1-C6 alkyl, CF 3, CHF 2, CH 2 F, CH 2 OH, COOH, C CH 3, CH2NHC OCH 2 CH 3, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 alkoxy, amino, C1-C6 alkylamine, C5-C6 aryl, C3-C6 heteroaryl, benzyl, oxo and amide. including a pharmaceutically acceptable salt, tautomer, stereoisomer or N -oxide derivative thereof, wherein: R 1 is H, OH or an optionally substituted alkyl group; R 2 is an optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C6 alkylcycloalkyl, optionally substituted C4-C6 aryl, optionally substituted C3-C6 heteroaryl, optionally substituted C4-C8 aryloxy, optionally substituted C7-C10 arylalkyl or optionally substituted C5-C10 heteroarylalkyl group; and Q is represented by formula: wherein: R 5a is H, halo, optionally substituted C1-C6 alkyl, or optionally substituted amino; R 5b is H, halo, optionally substituted C2-C6 alkynyl, benzyl, optionally monosubstituted C3-C6 heteroaryl, optionally substituted C3-C6 heterocycloalkyl, optionally substituted C1-C6 alkoxy, NR'R", or R a NR'R", wherein R a is C1-C6 alkyl or C2-C6 alkenyl; and R 1 is H, OH or an optionally substituted alkyl group; R 2 is an optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C6 alkylcycloalkyl, optionally substituted C4-C6 aryl, optionally substituted C3-C6 heteroaryl, optionally substituted C4-C8 aryloxy, optionally substituted C7-C10 arylalkyl or optionally substituted C5-C10 heteroarylalkyl group; and Q is represented by formula: wherein: R 5a is H, halo, optionally substituted C1-C6 alkyl, or optionally substituted amino; R 5b is H, halo, optionally substituted C2-C6 alkynyl, benzyl, optionally monosubstituted C3-C6 heteroaryl, optionally substituted C3-C6 heterocycloalkyl, optionally substituted C1-C6 alkoxy, NR'R", or R a NR'R", wherein R a is C1-C6 alkyl or C2-C6 alkenyl; and R 5a is H, halo, optionally substituted C1-C6 alkyl, or optionally substituted amino; R 5b is H, halo, optionally substituted C2-C6 alkynyl, benzyl, optionally monosubstituted C3-C6 heteroaryl, optionally substituted C3-C6 heterocycloalkyl, optionally substituted C1-C6 alkoxy, NR'R", or R a NR'R", wherein R a is C1-C6 alkyl or C2-C6 alkenyl; and wherein R' and R" are each independently selected from H, oxo-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, optionally substituted C1-C7 alkylamine, optionally substituted C2-C7 alkenylamine, optionally substituted C3-C10 heterocycloalkyl, optionally substituted C4-C10 aryl, optionally substituted C3-C10 heteroaryl, optionally substituted C5-C10 alkylaryl, optionally substituted C4-C10 alkylheterocycloalkyl, and C4-C6 alkylheteroaryl, or wherein R' and R" together form an optionally substituted C3-C8 heterocycloalkyl including the N to which they are attached, wherein for any of the functional groups for which one or more substituents are optional, the optional substituents are independently selected from OH, F, Cl, Br, I, CN, C1-C6 alkyl, CF 3, CHF 2, CH 2 F, CH 2 OH, COOH, C CH 3, CH2NHC OCH 2 CH 3, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 alkoxy, amino, C1-C6 alkylamine, C5-C6 aryl, C3-C6 heteroaryl, benzyl, oxo and amide.