A machine for the cold sanification of medical devices, wherein each medical device has a sheath enveloping one or more inner channels to be treated with one or more sanification fluids contained in respective reservoirs (S, S', S"), which machine comprises: - at least one sanification chamber adapted to housing at least one medical device to be treated; - means for supplying one or more sanification fluids comprising a plurality of hydraulic circuits (4, 4', 4") each having a drawing conduit (5, 5', 5") for the sanification fluids connectable to a respective reservoir (S, S', S") and a plurality of delivering conduits (6, 6', 6",...) having respective outlet (14, 14', 14") into said sanification chamber for introducing the pressurized fluids therein; - means for fluidically connecting one or more of said drawing conduits (6, 6', 6",...) with corresponding inner channels of the device housed into said sanification chamber; wherein said supplying means comprise a plurality of pipes having one end connected with a corresponding outlet (14, 14', 14",...) of a corresponding delivery conduit (6, 6', 6",...) and the opposite end adapted to be removably connected to a corresponding inner channel for supplying fluid directly thereinside with a predetermined pressure; characterized in that said supplying means comprise a central collector interposed between said drawing conduits (5, 5', 5") and said delivering conduits (6, 6', 6",..,) and having thereinside a mixing chamber of the sanification fluids drawn from the reservoirs (S, S', S",...) for receiving from said drawing conduits (5, 5', 5") the fluids to be supplied toward each of said delivering conduits (6, 6', 6",...), said mixing chamber having at least one inlet for said drawing conduits (5, 5', 5") and a plurality of outlets (12, 12', 12",...) in each of which a respective delivering conduit (6, 6', 6",...) is jointed to have at the corresponding outlets (14, 14', 14",...) pressures equal with each other. - at least one sanification chamber adapted to housing at least one medical device to be treated; - means for supplying one or more sanification fluids comprising a plurality of hydraulic circuits (4, 4', 4") each having a drawing conduit (5, 5', 5") for the sanification fluids connectable to a respective reservoir (S, S', S") and a plurality of delivering conduits (6, 6', 6",...) having respective outlet (14, 14', 14") into said sanification chamber for introducing the pressurized fluids therein; - means for fluidically connecting one or more of said drawing conduits (6, 6', 6",...) with corresponding inner channels of the device housed into said sanification chamber; wherein said supplying means comprise a plurality of pipes having one end connected with a corresponding outlet (14, 14', 14",...) of a corresponding delivery conduit (6, 6', 6",...) and the opposite end adapted to be removably connected to a corresponding inner channel for supplying fluid directly thereinside with a predetermined pressure; characterized in that said supplying means comprise a central collector interposed between said drawing conduits (5, 5', 5") and said delivering conduits (6, 6', 6",..,) and having thereinside a mixing chamber of the sanification fluids drawn from the reservoirs (S, S', S",...) for receiving from said drawing conduits (5, 5', 5") the fluids to be supplied toward each of said delivering conduits (6, 6', 6",...), said mixing chamber having at least one inlet for said drawing conduits (5, 5', 5") and a plurality of outlets (12, 12', 12",...) in each of which a respective delivering conduit (6, 6', 6",...) is jointed to have at the corresponding outlets (14, 14', 14",...) pressures equal with each other.