mhurhangee/ep-ind-claims huggingface dataset:
An oncolytic adenovirus comprising a sequence of formula: 5'ITR-B 1 -B A -B 2 -B X -B B -B Y -B 3 -3'ITR wherein: B 1 is bond or comprises: E1A, E1B or E1A-E1B; B A comprises-E2B-L1-L2-L3-E2A-L4; B 2 is a bond or comprises: E3; B X is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B B comprises L5; B Y is a DNA sequence comprising: a restriction site, one or more transgenes or both; B 3 is a bond or comprises: E4; wherein the adenovirus encodes a Bispecific T cell Engager in position B Y comprising at least two binding domains wherein: one of the said domains is specific to a component of the T-cell receptor complex; and another of the said domains is specific to a tumour stromal antigen; wherein the adenovirus is Enadenotucirev (EnAd) or serotype 11 adenovirus; and wherein the tumour stromal antigen is selected from: fibroblast activation protein, TREM1, IGFBP7, FSP-1, platelet-derived growth factor-α receptor (PDGFR-α), platelet-derived growth factor-β receptor (PDGFR-β) and vimentin. B 1 is bond or comprises: E1A, E1B or E1A-E1B; B A comprises-E2B-L1-L2-L3-E2A-L4; B 2 is a bond or comprises: E3; B X is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B B comprises L5; B Y is a DNA sequence comprising: a restriction site, one or more transgenes or both; B 3 is a bond or comprises: E4; wherein the adenovirus encodes a Bispecific T cell Engager in position B Y comprising at least two binding domains wherein: one of the said domains is specific to a component of the T-cell receptor complex; and another of the said domains is specific to a tumour stromal antigen; one of the said domains is specific to a component of the T-cell receptor complex; and another of the said domains is specific to a tumour stromal antigen; wherein the adenovirus is Enadenotucirev (EnAd) or serotype 11 adenovirus; and wherein the tumour stromal antigen is selected from: fibroblast activation protein, TREM1, IGFBP7, FSP-1, platelet-derived growth factor-α receptor (PDGFR-α), platelet-derived growth factor-β receptor (PDGFR-β) and vimentin.
An image transmitting device to be mounted on a vehicle, the image transmitting device comprising: a checking unit configured to check communicability with an external device (31, 32) outside of the vehicle; a providing unit configured to provide notification information based on a result of the checking by the checking unit; a capturing unit configured to capture an image; and a transmitting unit configured to transmit the image captured by the capturing unit to the external device (31, 32); characterized in that the checking unit is configured to perform the checking by measuring, at a parking place of the vehicle, reception electric field intensity of radio waves from the external device (31, 32); and the image transmitting device further comprises a positioning unit configured to measure a position of the vehicle, wherein the checking unit is further configured to examine communicability with the external device (31, 32) by measuring reception electric field intensity of radio waves from the external device (31, 32), at a place other than the parking place of the vehicle, and the providing unit is further configured to provide information based on a result of the examining, when a result of the checking shows that the communicability is denied, the information indicating a position which is within a predetermined distance range from the parking place of the vehicle and where communication with the external device (31, 32) is possible. a checking unit configured to check communicability with an external device (31, 32) outside of the vehicle; a providing unit configured to provide notification information based on a result of the checking by the checking unit; a capturing unit configured to capture an image; and a transmitting unit configured to transmit the image captured by the capturing unit to the external device (31, 32); characterized in that the checking unit is configured to perform the checking by measuring, at a parking place of the vehicle, reception electric field intensity of radio waves from the external device (31, 32); and the image transmitting device further comprises a positioning unit configured to measure a position of the vehicle, wherein the checking unit is further configured to examine communicability with the external device (31, 32) by measuring reception electric field intensity of radio waves from the external device (31, 32), at a place other than the parking place of the vehicle, and the providing unit is further configured to provide information based on a result of the examining, when a result of the checking shows that the communicability is denied, the information indicating a position which is within a predetermined distance range from the parking place of the vehicle and where communication with the external device (31, 32) is possible.
An electronic device, comprising: a first plate including a planar area oriented in a first direction, and a curved area extending from at least a portion of an edge of the planar area; a second plate oriented in a second direction opposite the first direction, the first plate and second plate defining an inner space; a support member disposed between the first plate and the second plate configured to surround the inner space; and a first adhesive member disposed between the curved area of the first plate and the support member, wherein the first adhesive member includes: a first adhesive layer attached to at least a portion of the curved area of the first plate, and is configured to be activated by heat, and a second adhesive layer attached to at least a portion of the support member, wherein the first adhesive layer is configured to be in an inactive state at a first temperature, wherein the first adhesive layer is configured to change from the inactive state to an active state in response to change from the first temperature to a second temperature higher than the first temperature, and wherein the second adhesive layer is formed of an adhesive material that is configured to be activated at the first temperature and deactivated at the second temperature. a first plate including a planar area oriented in a first direction, and a curved area extending from at least a portion of an edge of the planar area; a second plate oriented in a second direction opposite the first direction, the first plate and second plate defining an inner space; a support member disposed between the first plate and the second plate configured to surround the inner space; and a first adhesive member disposed between the curved area of the first plate and the support member, wherein the first adhesive member includes: a first adhesive layer attached to at least a portion of the curved area of the first plate, and is configured to be activated by heat, and a second adhesive layer attached to at least a portion of the support member, a first adhesive layer attached to at least a portion of the curved area of the first plate, and is configured to be activated by heat, and a second adhesive layer attached to at least a portion of the support member, wherein the first adhesive layer is configured to be in an inactive state at a first temperature, wherein the first adhesive layer is configured to change from the inactive state to an active state in response to change from the first temperature to a second temperature higher than the first temperature, and wherein the second adhesive layer is formed of an adhesive material that is configured to be activated at the first temperature and deactivated at the second temperature.
An earphone comprising: an earphone assembly having an earphone body with an inner surface, an acoustic opening and a cavity defined by the inner surface and the acoustic opening, the earphone assembly further including a first acoustic impedance branch extending from an open end at the inner surface to a closed end inside the earphone body, wherein the first acoustic impedance branch includes a branch volume that reduces a magnitude of a resonance at a first resonance frequency for an occluded ear canal defined by the cavity of the earphone assembly and an ear canal of a user when the earphone is at least partially inserted into the ear canal; a first electro-acoustic transducer disposed inside the earphone assembly and configured to generate a first acoustic signal in response to a first electrical signal; and a second electro-acoustic transducer disposed inside the earphone body along a length of the first acoustic impedance branch and configured to generate a second acoustic signal in response to a second electrical signal, wherein the first acoustic impedance branch comprises an acoustic waveguide having a length equal to one quarter of an acoustic wavelength for the first resonance frequency. an earphone assembly having an earphone body with an inner surface, an acoustic opening and a cavity defined by the inner surface and the acoustic opening, the earphone assembly further including a first acoustic impedance branch extending from an open end at the inner surface to a closed end inside the earphone body, wherein the first acoustic impedance branch includes a branch volume that reduces a magnitude of a resonance at a first resonance frequency for an occluded ear canal defined by the cavity of the earphone assembly and an ear canal of a user when the earphone is at least partially inserted into the ear canal; a first electro-acoustic transducer disposed inside the earphone assembly and configured to generate a first acoustic signal in response to a first electrical signal; and a second electro-acoustic transducer disposed inside the earphone body along a length of the first acoustic impedance branch and configured to generate a second acoustic signal in response to a second electrical signal,
A sleeve for mounting on a printing machine cylinder according to the principle of sleeve technology, with a first layer and a second layer and at least one first intermediate layer arranged in stable manner as to its form between the two layers (1; 2), in which the first layer is designed as a hollow cylinder, the at least one first intermediate layer has radial webs (3 to 18) arranged in fixed manner concentrically on the first layer, the radial webs (3 to 18) of the first intermediate layer are arranged according to a continuous pattern on the circumferential surface of the first layer, and the second layer is arranged in fixed manner and concentrically on the webs (3 to 18); characterized in that the intermediate layer is built according to the principle of lightweight construction and comprises, adjacent to the webs (3 to 18), associated free spaces, wherein the second layer is arranged to close the free spaces; in that the free spaces are arranged closed by the webs (3 to 18) and, when viewed in the radial direction, have a quadrilateral and polygonal cross-section; and in that the webs (3 to 18) and the free spaces extend completely in the circumferential and axial direction with respect to the first layer.
A method for detecting a compromised client device includes the steps of: monitoring an execution of an application by a client device, the client device comprising a set of protected resources that are unavailable for use by the application; identifying an exposed resource, the exposed resource comprising a protected resource having a privilege level modified to enable the protected resource to be available for use by the application; maintaining a record of exposed resources; detecting a hidden resource, the hidden resource available to the application but hidden from the record of exposed resources; selectively disabling the application in response to the detection of the hidden resource; and wherein the step of monitoring the execution of the application including monitoring the set of protected resources, includes a step of periodically issuing a series of access requests to the set of protected resources using a first access function to provide a series of point-in-time lists of exposed resources, and wherein the record of exposed resources comprises the series of point-in-time lists of exposed resources. monitoring an execution of an application by a client device, the client device comprising a set of protected resources that are unavailable for use by the application; identifying an exposed resource, the exposed resource comprising a protected resource having a privilege level modified to enable the protected resource to be available for use by the application; maintaining a record of exposed resources; detecting a hidden resource, the hidden resource available to the application but hidden from the record of exposed resources; selectively disabling the application in response to the detection of the hidden resource; and wherein the step of monitoring the execution of the application including monitoring the set of protected resources, includes a step of periodically issuing a series of access requests to the set of protected resources using a first access function to provide a series of point-in-time lists of exposed resources, and wherein the record of exposed resources comprises the series of point-in-time lists of exposed resources.
An active-active cluster control method, comprising: receiving, by a control node, a first query request sent by a first network processing node in an active-active cluster, wherein the first query request carries forwarding information of a first packet, and the forwarding information of the first packet records a sending direction of the first packet as an outbound direction; configuring, by the control node, an outbound forwarding rule based on the forwarding information of the first packet, generating an inbound forwarding rule whose direction is opposite to that of the outbound forwarding rule, recording the outbound forwarding rule and the inbound forwarding rule, and sending the outbound forwarding rule to the first network processing node; receiving, by the control node, a second query request sent by a second network processing node in the active-active cluster, wherein the second query request carries forwarding information of a second packet, and the forwarding information of the second packet records a sending direction of the second packet as an inbound direction; and determining, by the control node, that the forwarding information of the second packet matches the inbound forwarding rule, obtaining, based on the forwarding information of the second packet, the recorded inbound forwarding rule, and sending the inbound forwarding rule to the second network processing node. receiving, by a control node, a first query request sent by a first network processing node in an active-active cluster, wherein the first query request carries forwarding information of a first packet, and the forwarding information of the first packet records a sending direction of the first packet as an outbound direction; configuring, by the control node, an outbound forwarding rule based on the forwarding information of the first packet, generating an inbound forwarding rule whose direction is opposite to that of the outbound forwarding rule, recording the outbound forwarding rule and the inbound forwarding rule, and sending the outbound forwarding rule to the first network processing node; receiving, by the control node, a second query request sent by a second network processing node in the active-active cluster, wherein the second query request carries forwarding information of a second packet, and the forwarding information of the second packet records a sending direction of the second packet as an inbound direction; and determining, by the control node, that the forwarding information of the second packet matches the inbound forwarding rule, obtaining, based on the forwarding information of the second packet, the recorded inbound forwarding rule, and sending the inbound forwarding rule to the second network processing node.
Method for the production of a multilayer body (100, 200, 300), in particular an optical security element or an optical decorative element, wherein in the method: a) a monolayer or multilayer first decorative layer is applied to a carrier layer; b) at least one metal layer is applied to the side of the first decorative layer which is facing away from the carrier layer; c) the at least one metal layer is structured in such a way that the metal layer is provided in one or more first zones of the multilayer body (100, 200, 300) in a first layer thickness and is provided in one or more second zones of the multilayer body (100, 200, 300) in a second layer thickness which is different from the first layer thickness, wherein, in particular, the second layer thickness is equal to zero; d) a monolayer or multilayer second decorative layer is applied to the side of the metal layer which is facing away from the first decorative layer; characterised in that e) the first and/or second decorative layer using the metal layer as a mask is structured in a first region of the multilayer body in such a way that the first or second decorative layer is at least partially removed in the first or second zones. a) a monolayer or multilayer first decorative layer is applied to a carrier layer; b) at least one metal layer is applied to the side of the first decorative layer which is facing away from the carrier layer; c) the at least one metal layer is structured in such a way that the metal layer is provided in one or more first zones of the multilayer body (100, 200, 300) in a first layer thickness and is provided in one or more second zones of the multilayer body (100, 200, 300) in a second layer thickness which is different from the first layer thickness, wherein, in particular, the second layer thickness is equal to zero; d) a monolayer or multilayer second decorative layer is applied to the side of the metal layer which is facing away from the first decorative layer; characterised in that e) the first and/or second decorative layer using the metal layer as a mask is structured in a first region of the multilayer body in such a way that the first or second decorative layer is at least partially removed in the first or second zones.
A position estimation program causing a computer to execute a process, the process comprising: acquiring a captured image of an optical signal pattern including identification information pertaining to a mobile terminal; extracting the identification information from the captured image; estimating a position of the mobile terminal by estimating a position of the image of the optical signal pattern in the captured image; and transmitting notification information corresponding to the estimated position, wherein the transmitting includes identifying the mobile terminal of a destination based on the identification information and transmitting the notification information to the identified mobile terminal. acquiring a captured image of an optical signal pattern including identification information pertaining to a mobile terminal; extracting the identification information from the captured image; estimating a position of the mobile terminal by estimating a position of the image of the optical signal pattern in the captured image; and transmitting notification information corresponding to the estimated position, wherein the transmitting includes identifying the mobile terminal of a destination based on the identification information and transmitting the notification information to the identified mobile terminal.
A motor vehicle key having a housing, a printed circuit board accommodated in the housing, on which at least one electronic component is mounted, at least one pushbutton element which is operatively connected to the printed circuit board and mounted on the housing, an electrical energy source for operating the at least one electronic component and a first contact element and a second contact element that electrically couple the electrical energy source to the printed circuit board, wherein the electrical energy source is arranged at the side next to the printed circuit board and the electrical energy source a solution is extends over at least a height subsection of the printed circuit board relative to the height direction of the motor vehicle key, wherein the first contact element has a contact section with elastically movable contact fins which contact the electrical energy source on a surface section, wherein a self-supporting bridge connector which is attached to the printed circuit board extends between the contact section of the first contact element and the printed circuit board, assuring an electrical connection between the contact section and the printed circuit board, wherein the self-supporting bridge connector bridges a height difference between the contact section and the printed circuit board, wherein a support geometry supports the contact section of the first contact element in such manner that the support geometry protects the self-supporting bridge connector from damage, deformation or undesirable bending, and wherein the support geometry, the first contact element, the second contact element and the printed circuit board form a subassembly that can be transportable and fitted together, which is installed in the housing element.
Cross-country skiing kit having a cross-country binding and a cross-country boot, the cross-country binding being used connect the cross-country boot to a cross-country ski in an articulated manner, comprising - a substantially unyielding binding base body that has a standing surface for a sole of the cross-country boot, - a holding device that has a receptacle for pivotable arrangement of the cross-country boot about a pivot axis extending in the transverse direction of the binding base body, and - an elastically deformable reset element for resetting the cross-country boot from an upwardly pivoted position in the direction of the standing surface of the binding base body, the reset element being arranged on the cross-country binding, - at least one substantially unyielding elevation being provided on the standing surface of the binding base body, behind the pivot axis in the longitudinal direction of the binding base body, by means of which elevation the sole of the cross-country boot is arranged in its unloaded state at a distance from the standing surface of the binding base body, characterised in that the cross-country boot has a pivot pin for pivotable arrangement in the receptacle, and in that, in the unloaded state, the cross-country boot approaches at most an angle other than zero to the standing surface of the binding base body, due to the elevation. - a substantially unyielding binding base body that has a standing surface for a sole of the cross-country boot, - a holding device that has a receptacle for pivotable arrangement of the cross-country boot about a pivot axis extending in the transverse direction of the binding base body, and - an elastically deformable reset element for resetting the cross-country boot from an upwardly pivoted position in the direction of the standing surface of the binding base body, the reset element being arranged on the cross-country binding, - at least one substantially unyielding elevation being provided on the standing surface of the binding base body, behind the pivot axis in the longitudinal direction of the binding base body, by means of which elevation the sole of the cross-country boot is arranged in its unloaded state at a distance from the standing surface of the binding base body,