mhurhangee/ep-ind-claims huggingface dataset:
A process for the manufacture of or pharmaceutically acceptable salts thereof (Compound I), said method comprising reacting a compound of formula II wherein X represents Br or I, with a compound of formula III wherein Y represents Cl or Br and R' represents hydrogen or a metal ion, and a compound of formula IV wherein R represents hydrogen or a protective group, in the presence of a solvent, a base and a palladium catalyst consisting of a palladium source and a phosphine ligand at a temperature between 50°C and 130°C, wherein when R represents a protective group, said protective group is removed in a subsequent step.
A method for providing trusted e-mail communication, the method comprising: receiving a message from a message source organization for a recipient organization; identifying the message source organization; determining whether the recipient organization supports an attribution data extension; and in response to determining that the recipient organization supports the attribution data extension, transmitting (250, 260) the message to the recipient organization with an attribution element associated with the message source organization, wherein the attribution data identifies a trusted message source organization, wherein the transmitting comprises transmitting a Simple Message Transport Protocol, SMTP, command comprising the attribution element to the recipient organization. receiving a message from a message source organization for a recipient organization; identifying the message source organization; determining whether the recipient organization supports an attribution data extension; and in response to determining that the recipient organization supports the attribution data extension, transmitting (250, 260) the message to the recipient organization with an attribution element associated with the message source organization, wherein the attribution data identifies a trusted message source organization, wherein the transmitting comprises transmitting a Simple Message Transport Protocol, SMTP, command comprising the attribution element to the recipient organization.
A computer-implemented method, comprising: receiving an input at a service portal of a mobile telecommunication network, the input configuring multiple user devices to share in use a common telephone number to initiate and receive communications via the mobile telecommunication network; storing the input as a device association profile in a device association data store that is accessible by a call session control function, CSCF, node of the mobile telecommunication network; determining at the CSCF node based at least on the device association profile whether a user device is eligible to use the common telephone number to initiate and receive communications via the mobile telecommunication network; and sending, from the CSCF node, a registration message to a Telephony Application Server, TAS, of the mobile telecommunication network, wherein the registration with the TAS enables the TAS to send communications for the common telephone number to the CSCF node for routing to each user device that shares the common telephone number. receiving an input at a service portal of a mobile telecommunication network, the input configuring multiple user devices to share in use a common telephone number to initiate and receive communications via the mobile telecommunication network; storing the input as a device association profile in a device association data store that is accessible by a call session control function, CSCF, node of the mobile telecommunication network; determining at the CSCF node based at least on the device association profile whether a user device is eligible to use the common telephone number to initiate and receive communications via the mobile telecommunication network; and sending, from the CSCF node, a registration message to a Telephony Application Server, TAS, of the mobile telecommunication network, wherein the registration with the TAS enables the TAS to send communications for the common telephone number to the CSCF node for routing to each user device that shares the common telephone number.
Airplane comprising a lifting element, a fuselage and a girder for coupling the lifting element with the fuselage, wherein the fuselage comprises a former for seating and fixing the girder, wherein the former comprises an insert placed in an opening in the former, wherein the insert has an inner shape that represents the outer shape of an end of the girder, characterized in that the insert has an outer shape that represents the inner shape of the former of the fuselage, wherein the height of the insert as measured along the opening in the former corresponds to at most a half of the depth of the opening in the former.
An electrode for an energy storage device characterized in that a foil-like lead electrode for a positive electrode in which Zn layer or Zn alloy layer, Ni layer, and Sn layer or Sn alloy layer are formed on the positive electrode containing Al by plating, and a foil-like lead electrode for a negative electrode containing Cu are connected to each other by soldering.
A method of producing elvitegravir of formula I, starting from dimethoxy derivatives of the general formula II, wherein X is Cl, Br, or I, and wherein R is an (un)branched C 1 -C 4 alkyl, characterized in reacting with a suitable silylation agent, selected among O,N -bis-trimethylsilylacetamide, O,N -bis-trimethylsilyltrifluoroacetamide or N -methyl-trimethylsilylacetamide, in a solvent, selected among an excess of the silylation agent used or dimethyl formamide, to provide in situ, after processing and isolation, the corresponding silylated intermediate III, wherein X and R have the above mentioned meaning, which then provides, through a reaction with the organozinc reagent of formula IV, an intermediate of the general formula V, wherein R is an (un)branched C 1 -C 4 alkyl, which is optionally crystallized from a crystallization solvent and further hydrolyzed to elvitegravir, which is optionally further crystallized from another crystallization solvent.
A barrel for directing the path of a dischargeable projectile, comprising: an inner liner defining an axial bore; and an outer shell surrounding and in direct contact with the inner liner, said outer shell fabricated from a polymer matrix composite, said PMC comprising a resin mixture and fibers, characterized by said resin mixture comprising generally spherical metallic particles (76, 78, 80), said metallic particles comprising a plurality of sizes between about 0.1 microns and 10.0 microns in diameter.
Combined appliance comprising a hob with an integrated fume extraction device having a fume extraction housing and an air duct, wherein the hob has a cover plate with a cutout, which is provided in the central region of the cover plate, wherein an accommodating space in the fume extraction housing for a fan has an upper face with an air inlet opening, wherein the upper face in at least some regions is adjacent to the lower face of the hob and the air inlet opening is located below the cutout, an end of the air duct is connected to the fume extraction housing, characterised in that the air duct has a vertical region which runs downward, the air duct contains at least one circulating air filter, the circulating air filter is retained in a circulating air module which has a drawer for the circulating air filter and the circulating air module is arranged in the vertical region of the air duct.
A method of synthesizing a zincoaluminosilicate molecular sieve having the framework structure of SSZ-41, the method comprising: (a) preparing a reaction mixture comprising: a combined source of silicon oxide and aluminum oxide which is a FAU framework type zeolite; a source of zinc; a source of a Group 1 or Group 2 metal; a structure directing agent comprising 1,1'-(1,4-butanediyl)bis-4-aza-1-azoniabicyclo[2.2.2]octane dications; hydroxide ions; and water; and (b) subjecting the reaction mixture to crystallization conditions sufficient to form crystals of the molecular sieve; wherein the reaction mixture has a composition, in terms of molar ratios, as follows: SiO 2 /Al 2 O 3 60 to 90 SiO 2 /ZnO 15 to 40 M/SiO 2 0.10 to 0.30 Q/SiO 2 0.15 to 0.40 OH/SiO 2 0.15 to 0.40 H 2 O/SiO 2 15 to 45. (a) preparing a reaction mixture comprising: a combined source of silicon oxide and aluminum oxide which is a FAU framework type zeolite; a source of zinc; a source of a Group 1 or Group 2 metal; a structure directing agent comprising 1,1'-(1,4-butanediyl)bis-4-aza-1-azoniabicyclo[2.2.2]octane dications; hydroxide ions; and water; and a combined source of silicon oxide and aluminum oxide which is a FAU framework type zeolite; a source of zinc; a source of a Group 1 or Group 2 metal; a structure directing agent comprising 1,1'-(1,4-butanediyl)bis-4-aza-1-azoniabicyclo[2.2.2]octane dications; hydroxide ions; and water; and (b) subjecting the reaction mixture to crystallization conditions sufficient to form crystals of the molecular sieve;
Separation media for use in the high pressure chromatographic separation of a sample mixture, said separation media comprising first particles of a first material and second particles of a second material, said first particles being sized between 1 and 100 μm, said first particles being capable of at least temporarily retaining at least one component of a sample mixture, and said second material being selected to have a higher thermal conductivity than said first material, wherein said first material comprises a siliceous polymer represented by (i) the formula SiO 2 /[R 2 p R 4 q SiO t] n, where R 2 and R 4 are independently C 1 - C 18 aliphatic or aromatic moieties, p+q = 1 or 2, provided that t = 1.5 if p+q = 1 and t = 1 if p+q = 2, and n is a number between 0.03 and 1, or (ii) the formula SiO 2 /[R 6 (R 2 r SiO t) m] n, where R 2 is C 1 - C 18 aliphatic or aromatic moiety, R 6 is a substituted or unsubstituted C 1 - C 18 alkylene, alkynylene, or arylene moiety bridging two or more silicon atoms, r = 0 or 1, provided that t = 1.5 if r = 0 and t = 1 if r = 1, m is an integer ≥ 2, and n is a number between 0.03 and 1; and said second material is selected from the group consisting of diamond and graphite.
An impact protection arrangement for persons for shielding obstacles, such as mast, snow cannon lance, tree, etc., in the area of sports-runs, in particular ski, sled, bicycle, comprising: a protective unit, which at least partially surrounds the obstacle and extends along a longitudinal axis of the obstacle and which can be rotatably mounted on the obstacle, the protective unit having an inner fastening region and an impact sleeve which surrounds the inner fastening region and which is resiliently connected to the fastening region via a support arrangement at a radial distance from the fastening region, wherein the support arrangement comprises a plurality of flexible deformable support elements which are arranged and formed between the impact sleeve and fastening region in such a way that the impact sleeve rotates about the fastening region in the event of an impact in such a way that an impacting person is displaced from a front region into a flank region of the impact protection arrangement. a protective unit, which at least partially surrounds the obstacle and extends along a longitudinal axis of the obstacle and which can be rotatably mounted on the obstacle, the protective unit having an inner fastening region and an impact sleeve which surrounds the inner fastening region and which is resiliently connected to the fastening region via a support arrangement at a radial distance from the fastening region, wherein the support arrangement comprises a plurality of flexible deformable support elements which are arranged and formed between the impact sleeve and fastening region in such a way that the impact sleeve rotates about the fastening region in the event of an impact in such a way that an impacting person is displaced from a front region into a flank region of the impact protection arrangement.
A modified Pantoea ananatis microorganism which has the ability of producing L-glutamic acid and has been modified so that the potassium transporting P-type ATPase ( kdp) system, encoded by the kdp operon, is enhanced when compared to an unmodified strain, wherein the kdp system is enhanced so that the P-type ATPase activity of the microorganism is enhanced, by increasing expression of said kdp operon or one or more genes constituting said kdp operon, and/or increasing translation of said kdp operon or of said genes, by increasing the copy number of said kdp operon or one or more of said genes, or modifying an expression control sequence of said operon.
An apparatus for liquid disinfection by ultraviolet light, the apparatus comprising: a conduit to carry a flowing liquid to be disinfected, wherein the conduit comprises three or more UV transparent conduit elements joined by two or more metal ring-shaped housings, wherein each of the UV transparent conduit elements is made of quartz and surrounded by air; two or more UV transparent sleeves, each located within one of the metal ring-shaped housings substantially perpendicular to the direction of flow and to the longitudinal axis of the conduit and positioned such that adjacent sleeves are orthogonal to each other; and two or more UV sources, each located within one of the UV transparent sleeves, wherein the apparatus is configured such that at least part of UV light emitted from the UV sources and directed onto one of the UV transparent conduit elements is totally-internally reflected. a conduit to carry a flowing liquid to be disinfected, wherein the conduit comprises three or more UV transparent conduit elements joined by two or more metal ring-shaped housings, wherein each of the UV transparent conduit elements is made of quartz and surrounded by air; two or more UV transparent sleeves, each located within one of the metal ring-shaped housings substantially perpendicular to the direction of flow and to the longitudinal axis of the conduit and positioned such that adjacent sleeves are orthogonal to each other; and two or more UV sources, each located within one of the UV transparent sleeves, wherein the apparatus is configured such that at least part of UV light emitted from the UV sources and directed onto one of the UV transparent conduit elements is totally-internally reflected.
A device for fixing two parts (1, 2) to one another, said parts being a bumper and a body element of a motor vehicle, the device being intended for housing and retaining in its interior a portion of at least a first of the parts (1, 2), characterized in that it includes a stationary portion and a removable portion which are superposed in a fixing position of the device with a spacing between the two portions (4, 8), the spacing comprising zone for housing and retaining the portions (1a, 2a) of the first and second parts (1, 2) superposed with respect to one another, a passage, supported by an end of each of the stationary and removable portions, being offset on the device relative to the housing zone, this passage receiving a fixing means (12, 12a) of the portions (4, 8) with one another.
A method for rapidly restoring an application from a set of one or more backup images to a target node, comprising: selecting said backup images; creating addressable virtual storage LUNs from said backup images on an on-demand basis; making said virtual storage LUNs visible to said target node; attaching said virtual storage LUNs as local disks on the restore target via iSCSI protocols; and programmatically recovering said application using application-specific APIs to apply application-specific log files. selecting said backup images; creating addressable virtual storage LUNs from said backup images on an on-demand basis; making said virtual storage LUNs visible to said target node; attaching said virtual storage LUNs as local disks on the restore target via iSCSI protocols; and programmatically recovering said application using application-specific APIs to apply application-specific log files.
A method of preparing antigen-specific CD4+ T cells or dendritic cells loaded with an antigen, the method comprising: culturing dendritic cells ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor and loading the dendritic cells with an antigen, wherein the culturing ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor is in amounts of the IL-15 and the p38 MAP kinase inhibitor and for a time effective to increase TNF-alpha expression and CCR4 expression and decrease FoxP3 expression in CD4+ T cells contacted with the dendritic cells as compared to CD4+ T cells contacted with dendritic cells that are cultured with GM-CSF and IL-4 without IL-15 and without the p38 MAP kinase inhibitor; and/or stimulating antigen-specific CD4+ T cells ex vivo with dendritic cells that are cultured ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor and loaded with an antigen, wherein the culturing of the dendritic cells ex vivo in GM-CSF, IL-4, IL-15, and the p38 MAP kinase inhibitor is in amounts of IL-15 and the p38 MAP kinase inhibitor and for a time effective to increase TNF-alpha expression and CCR4 expression and reduce FoxP3 expression of the antigen-specific CD4+ T cells as compared to antigen-specific CD4+ T cells stimulated ex vivo with dendritic cells that are cultured with GM-CSF and IL-4 without IL-15 and without the p38 MAP kinase inhibitor. culturing dendritic cells ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor and loading the dendritic cells with an antigen, wherein the culturing ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor is in amounts of the IL-15 and the p38 MAP kinase inhibitor and for a time effective to increase TNF-alpha expression and CCR4 expression and decrease FoxP3 expression in CD4+ T cells contacted with the dendritic cells as compared to CD4+ T cells contacted with dendritic cells that are cultured with GM-CSF and IL-4 without IL-15 and without the p38 MAP kinase inhibitor; and/or stimulating antigen-specific CD4+ T cells ex vivo with dendritic cells that are cultured ex vivo in GM-CSF, IL-4, IL-15, and a p38 MAP kinase inhibitor and loaded with an antigen, wherein the culturing of the dendritic cells ex vivo in GM-CSF, IL-4, IL-15, and the p38 MAP kinase inhibitor is in amounts of IL-15 and the p38 MAP kinase inhibitor and for a time effective to increase TNF-alpha expression and CCR4 expression and reduce FoxP3 expression of the antigen-specific CD4+ T cells as compared to antigen-specific CD4+ T cells stimulated ex vivo with dendritic cells that are cultured with GM-CSF and IL-4 without IL-15 and without the p38 MAP kinase inhibitor.
A method for managing, by a computer system, the operation of an intrusion detection device of an anti-theft apparatus of a motor vehicle, said intrusion detection device comprising at least one ultrasonic sensor, characterized in that the method comprises the steps of: • determine whether data characterising a wake-up signal intended for a siren of the anti-theft equipment and transmitted by an electronic control unit of the vehicle are received; and, where it is established that this is the case, • determine the duration of a time interval between the current moment and the time at which the next time an intrusion detection in the vehicle by means of the sensor will take place; and, where it is established that the duration is less than or equal to a pre-established threshold value, • cause an intrusion detection in the vehicle by means of the sensor; and • determine, depending on the current time, a later time for the next ingress detection in the vehicle by means of the sensor; or, where it is established that the duration is greater than the threshold value, • manage the operation of the intrusion detection device in a mode of operation in which its power consumption is reduced. • determine whether data characterising a wake-up signal intended for a siren of the anti-theft equipment and transmitted by an electronic control unit of the vehicle are received; and, where it is established that this is the case, • determine the duration of a time interval between the current moment and the time at which the next time an intrusion detection in the vehicle by means of the sensor will take place; and, where it is established that the duration is less than or equal to a pre-established threshold value, • cause an intrusion detection in the vehicle by means of the sensor; and • determine, depending on the current time, a later time for the next ingress detection in the vehicle by means of the sensor; or, where it is established that the duration is greater than the threshold value, • manage the operation of the intrusion detection device in a mode of operation in which its power consumption is reduced.
A system for pacing transmission from a plurality of transmit queues in a memory of a host computer accessible to a network interface device via a communication bus, the system comprising at the network interface device: a plurality of bins (240, 250, 260), each bin having a specified pacing threshold; characterized in that the system comprises: a pace table storing pace values for the plurality of transmit queues; a bus interface unit configured to allow the host computer system to write pace values over the communication bus to the pace table for the plurality of transmit queues; a binning controller for assigning queue identifiers of the plurality of transmit queues to the plurality of bins in dependence upon the pace values stored at the pace table; and an output arbiter (230, 235, 270, 280) configured to select queue identifiers from the plurality of bins in accordance with the specified pacing thresholds of the bins, the queue identifiers identifying transmit queues having data packets for transmission and the bins being accessible to the output arbiter without accessing the communication bus. a pace table storing pace values for the plurality of transmit queues; a bus interface unit configured to allow the host computer system to write pace values over the communication bus to the pace table for the plurality of transmit queues; a binning controller for assigning queue identifiers of the plurality of transmit queues to the plurality of bins in dependence upon the pace values stored at the pace table; and an output arbiter (230, 235, 270, 280) configured to select queue identifiers from the plurality of bins in accordance with the specified pacing thresholds of the bins, the queue identifiers identifying transmit queues having data packets for transmission and the bins being accessible to the output arbiter without accessing the communication bus.