An infant feeding system comprising: a nipple formed of a deformable material, the nipple comprising: a connector configured to be coupled to a container of liquid, wherein (i) the container is a spout pouch having an opening, (ii) the connector includes a connector region configured to engage with the opening of the spout pouch so as to form a liquid tight seal with the opening without need for additional hardware, and (iii) the connector includes an axial bore; and a tip region configured to be placed in a mouth of an infant, the tip region having an orifice in communication with the axial bore, so that the liquid can flow from the container through the axial bore and the orifice into the mouth of the infant; the spout pouch having a spout and a pouch, wherein the connector of the nipple is configured to engage with the spout so as to form the liquid tight seal with the spout without the need for additional hardware, the spout having (i) a longitudinal axis through a center of the spout and (ii) an inner surface that includes a feature selected from the group consisting of a ridge, rib, boss, recess, groove and step, the feature configured to engage with the connector when the connector is inserted into the spout; and the pouch comprising flexible material coupled to the spout, the pouch configured to hold the liquid; and a holder having a top and a body, wherein the top of the holder has an opening configured to removably receive and snap fit to the spout and the body has an interior configured to receive the spout pouch, the spout having an outer surface with two flanges (40a, 40b) that are spaced apart such that an upper flange is above the top of the holder, and a lower flange is below the top of the holder 12, the flanges (40a, 40b) configured to prevent movement of the spout and pouch within the holder along the longitudinal axis of the spout. a nipple formed of a deformable material, the nipple comprising: a connector configured to be coupled to a container of liquid, wherein (i) the container is a spout pouch having an opening, (ii) the connector includes a connector region configured to engage with the opening of the spout pouch so as to form a liquid tight seal with the opening without need for additional hardware, and (iii) the connector includes an axial bore; and a tip region configured to be placed in a mouth of an infant, the tip region having an orifice in communication with the axial bore, so that the liquid can flow from the container through the axial bore and the orifice into the mouth of the infant; a connector configured to be coupled to a container of liquid, wherein (i) the container is a spout pouch having an opening, (ii) the connector includes a connector region configured to engage with the opening of the spout pouch so as to form a liquid tight seal with the opening without need for additional hardware, and (iii) the connector includes an axial bore; and a tip region configured to be placed in a mouth of an infant, the tip region having an orifice in communication with the axial bore, so that the liquid can flow from the container through the axial bore and the orifice into the mouth of the infant; the spout pouch having a spout and a pouch, wherein the connector of the nipple is configured to engage with the spout so as to form the liquid tight seal with the spout without the need for additional hardware, the spout having (i) a longitudinal axis through a center of the spout and (ii) an inner surface that includes a feature selected from the group consisting of a ridge, rib, boss, recess, groove and step, the feature configured to engage with the connector when the connector is inserted into the spout; and the pouch comprising flexible material coupled to the spout, the pouch configured to hold the liquid; and a holder having a top and a body, wherein the top of the holder has an opening configured to removably receive and snap fit to the spout and the body has an interior configured to receive the spout pouch, the spout having an outer surface with two flanges (40a, 40b) that are spaced apart such that an upper flange is above the top of the holder, and a lower flange is below the top of the holder 12, the flanges (40a, 40b) configured to prevent movement of the spout and pouch within the holder along the longitudinal axis of the spout.