A combination biopsy and marker placement device, comprising: a first portion comprising (20, 52) an introducer conduit; a second portion (21, 54) that is securable to the first portion (20, 52) at a selected relative position within a range of available positions, the second portion comprising: a body; a slider movable along a longitudinal axis of the device; a biasing element that biases the slider in a deployment direction; a trigger movable along the longitudinal axis of the device; a plurality of coaxial tine assemblies, wherein a first portion of each of the tine assemblies are coupled for movement with the trigger and a second portion of each of the tine assemblies are coupled for movement with the slider; wherein, in use, the second portion (21, 54) is coupled to the first portion (20, 52) at the selected position, the slider is retracted against the force of the biasing element, the trigger is depressed to simultaneously or substantially simultaneously deploy the first portions of the tine assemblies and the slider is released to deploy the second portions of the tine assemblies, wherein the tissue samples are taken when the second portions of the tine assemblies are deployed over the first portions, characterized in that: the first portion comprises a stylet, each tine assembly carries a marker, and wherein, in use, the introducer conduit is positioned at a desired location within an organ or tissue and the stylet is removed from the introducer conduit, and wherein when the tine assemblies are removed the markers are left in place. a first portion comprising (20, 52) an introducer conduit; a second portion (21, 54) that is securable to the first portion (20, 52) at a selected relative position within a range of available positions, the second portion comprising: a body; a slider movable along a longitudinal axis of the device; a biasing element that biases the slider in a deployment direction; a trigger movable along the longitudinal axis of the device; a plurality of coaxial tine assemblies, wherein a first portion of each of the tine assemblies are coupled for movement with the trigger and a second portion of each of the tine assemblies are coupled for movement with the slider; a body; a slider movable along a longitudinal axis of the device; a biasing element that biases the slider in a deployment direction; a trigger movable along the longitudinal axis of the device; a plurality of coaxial tine assemblies, wherein a first portion of each of the tine assemblies are coupled for movement with the trigger and a second portion of each of the tine assemblies are coupled for movement with the slider; wherein, in use, the second portion (21, 54) is coupled to the first portion (20, 52) at the selected position, the slider is retracted against the force of the biasing element, the trigger is depressed to simultaneously or substantially simultaneously deploy the first portions of the tine assemblies and the slider is released to deploy the second portions of the tine assemblies, wherein the tissue samples are taken when the second portions of the tine assemblies are deployed over the first portions, characterized in that: the first portion comprises a stylet, each tine assembly carries a marker, and wherein, in use, the introducer conduit is positioned at a desired location within an organ or tissue and the stylet is removed from the introducer conduit, and wherein when the tine assemblies are removed the markers are left in place. the first portion comprises a stylet, each tine assembly carries a marker, and wherein, in use, the introducer conduit is positioned at a desired location within an organ or tissue and the stylet is removed from the introducer conduit, and wherein when the tine assemblies are removed the markers are left in place.