Interferometric system for detecting analytes present in a fluid sample, including: ∘ a matrix of Mach-Zehnder interferometers, intended to be coupled on one side to at least one laser source and on another side to a plurality of photodetectors, each interferometer including two waveguides forming the arms of the interferometer, the arms extending in a spiral and/or in a coil with an aspect ratio of 1, • the interferometers being arranged in a periodic and rectangular manner, and aligned in columns along a longitudinal axis passing between the arms of each interferometer, and in rows along a transverse axis orthogonal to the longitudinal axis; ∘ a matrix of sensitive surfaces each formed by receptors with which the analytes are able to interact by adsorption/desorption, each sensitive surface at least partly covering one of the arms of an interferometer, which then forms a sensitive arm, and not covering the other arm, which then forms a reference arm; ∘ characterised in that: • the sensitive surfaces are arranged periodically and hexagonally, so that the sensitive surfaces on one and the same row are each positioned on the same side of the longitudinal axis passing between the two arms of the interferometer in question, the side where the sensitive surfaces are positioned with respect to the interferometers in one and the same column then alternating from one row to another. ∘ a matrix of Mach-Zehnder interferometers, intended to be coupled on one side to at least one laser source and on another side to a plurality of photodetectors, each interferometer including two waveguides forming the arms of the interferometer, the arms extending in a spiral and/or in a coil with an aspect ratio of 1, • the interferometers being arranged in a periodic and rectangular manner, and aligned in columns along a longitudinal axis passing between the arms of each interferometer, and in rows along a transverse axis orthogonal to the longitudinal axis; • the interferometers being arranged in a periodic and rectangular manner, and aligned in columns along a longitudinal axis passing between the arms of each interferometer, and in rows along a transverse axis orthogonal to the longitudinal axis; ∘ a matrix of sensitive surfaces each formed by receptors with which the analytes are able to interact by adsorption/desorption, each sensitive surface at least partly covering one of the arms of an interferometer, which then forms a sensitive arm, and not covering the other arm, which then forms a reference arm; ∘ characterised in that: • the sensitive surfaces are arranged periodically and hexagonally, so that the sensitive surfaces on one and the same row are each positioned on the same side of the longitudinal axis passing between the two arms of the interferometer in question, the side where the sensitive surfaces are positioned with respect to the interferometers in one and the same column then alternating from one row to another. • the sensitive surfaces are arranged periodically and hexagonally, so that the sensitive surfaces on one and the same row are each positioned on the same side of the longitudinal axis passing between the two arms of the interferometer in question, the side where the sensitive surfaces are positioned with respect to the interferometers in one and the same column then alternating from one row to another.