A method for determining a glucose analyte concentration in a blood sample using an electrochemical biosensor system, the method comprising: determining a fill state of a test sensor to be either an underfill state or a substantial full-fill state; if the fill state of the test sensor is the underfill state, signaling for the addition of additional sample to substantially full-fill the test sensor from the underfill state to the substantial full-fill state; if the fill state of the test sensor is the underfill state, adding additional sample to the test sensor and detecting whether the test sensor is in the substantially full-fill state; if the test sensor is still in the underfill state, go back to signaling for the addition of additional sample to substantially full-fill the test sensor from the underfill state to the substantial full-fill state; if the fill state is a substantial full-fill state, applying an analytic test excitation signal to the sample, the analytic test excitation signal being an electrical signal; generating at least one analytic output signal value responsive to the concentration of the analyte in the sample and the analytic test excitation signal, the analytic output signal being an electrical signal; compensating at least one analytic output signal value depending on whether the substantial full-fill state of the test sensor is an initial or subsequent substantial full-fill state of the test sensor, where the compensating includes: the electrochemical biosensor system selecting a slope-based compensation equation depending on whether the fill state is the initial or subsequent substantial full-fill state of the test sensor, the compensation equation including at least one index function responsive to an error parameter, the error parameter being hematocrit and/or temperature; and determining an analyte concentration in the sample from the at least one analytic output signal value and the compensation equation. determining a fill state of a test sensor to be either an underfill state or a substantial full-fill state; if the fill state of the test sensor is the underfill state, signaling for the addition of additional sample to substantially full-fill the test sensor from the underfill state to the substantial full-fill state; if the fill state of the test sensor is the underfill state, adding additional sample to the test sensor and detecting whether the test sensor is in the substantially full-fill state; if the test sensor is still in the underfill state, go back to signaling for the addition of additional sample to substantially full-fill the test sensor from the underfill state to the substantial full-fill state; if the fill state is a substantial full-fill state, applying an analytic test excitation signal to the sample, the analytic test excitation signal being an electrical signal; generating at least one analytic output signal value responsive to the concentration of the analyte in the sample and the analytic test excitation signal, the analytic output signal being an electrical signal; compensating at least one analytic output signal value depending on whether the substantial full-fill state of the test sensor is an initial or subsequent substantial full-fill state of the test sensor, where the compensating includes: the electrochemical biosensor system selecting a slope-based compensation equation depending on whether the fill state is the initial or subsequent substantial full-fill state of the test sensor, the compensation equation including at least one index function responsive to an error parameter, the error parameter being hematocrit and/or temperature; and determining an analyte concentration in the sample from the at least one analytic output signal value and the compensation equation. the electrochemical biosensor system selecting a slope-based compensation equation depending on whether the fill state is the initial or subsequent substantial full-fill state of the test sensor, the compensation equation including at least one index function responsive to an error parameter, the error parameter being hematocrit and/or temperature; and determining an analyte concentration in the sample from the at least one analytic output signal value and the compensation equation.