A method for reconstructing an image from anatomical projection data of a moving tissue of interest, acquired during a plurality of motion phases, comprising: manipulating segmented tissue of interest, which is segmented from first reconstructed image data at a reference motion phase of interest, that is registered to second reconstructed image data at one or more other motion phases, updating initial motion vector fields corresponding to the registration of the segmented tissue of interest to the second reconstructed image data based on the manipulation; and reconstructing the projection data with a motion compensated reconstruction algorithm employing the updated motion vector fields, characterized by further comprising: validating the updated motion vector fields prior to employing the updated motion vector fields to reconstruct, the validating, comprising: computing a similarity measure between first reconstructed image data at the motion phase of interest and second reconstructed image data at the one or more other motion phases after the manipulation; comparing the similarity measure to a predetermined threshold; and validating the updated motion vector in response to the similarity measure satisfying the predetermined threshold. manipulating segmented tissue of interest, which is segmented from first reconstructed image data at a reference motion phase of interest, that is registered to second reconstructed image data at one or more other motion phases, updating initial motion vector fields corresponding to the registration of the segmented tissue of interest to the second reconstructed image data based on the manipulation; and reconstructing the projection data with a motion compensated reconstruction algorithm employing the updated motion vector fields, characterized by further comprising: validating the updated motion vector fields prior to employing the updated motion vector fields to reconstruct, the validating, comprising: computing a similarity measure between first reconstructed image data at the motion phase of interest and second reconstructed image data at the one or more other motion phases after the manipulation; comparing the similarity measure to a predetermined threshold; and validating the updated motion vector in response to the similarity measure satisfying the predetermined threshold. validating the updated motion vector fields prior to employing the updated motion vector fields to reconstruct, the validating, comprising: computing a similarity measure between first reconstructed image data at the motion phase of interest and second reconstructed image data at the one or more other motion phases after the manipulation; comparing the similarity measure to a predetermined threshold; and validating the updated motion vector in response to the similarity measure satisfying the predetermined threshold. computing a similarity measure between first reconstructed image data at the motion phase of interest and second reconstructed image data at the one or more other motion phases after the manipulation; comparing the similarity measure to a predetermined threshold; and validating the updated motion vector in response to the similarity measure satisfying the predetermined threshold.