A ventilator system for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea event(s) overlap syndrome, the system comprising: a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of a subject; one or more sensors configured to generate output signals conveying information related to one or more parameters related to breathable gas; and one or more physical computer processors operatively connected to the one or more sensors and the pressure generator, the one or more physical computer processors configured by computer readable instructions to: detect presence of obstructive sleep apnea OSA event(s) and expiratory flow limitation in the subject based on the output signals; and responsive to detecting concurrent presence of OSA event(s) and EFL: determine one or more OSA event(s) therapy parameters for treating the detected obstructive sleep apnea in the subject; determine one or more EFL therapy parameters for treating the detected expiratory flow limitation in the subject; determine a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters, the priority treatment prioritizing treatment of the detected OSA event(s) over treatment for the detected EFL; and control the pressure generator to deliver the determined priority treatment to the subject. a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of a subject; one or more sensors configured to generate output signals conveying information related to one or more parameters related to breathable gas; and one or more physical computer processors operatively connected to the one or more sensors and the pressure generator, the one or more physical computer processors configured by computer readable instructions to: detect presence of obstructive sleep apnea OSA event(s) and expiratory flow limitation in the subject based on the output signals; and responsive to detecting concurrent presence of OSA event(s) and EFL: determine one or more OSA event(s) therapy parameters for treating the detected obstructive sleep apnea in the subject; determine one or more EFL therapy parameters for treating the detected expiratory flow limitation in the subject; determine a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters, the priority treatment prioritizing treatment of the detected OSA event(s) over treatment for the detected EFL; and control the pressure generator to deliver the determined priority treatment to the subject. detect presence of obstructive sleep apnea OSA event(s) and expiratory flow limitation in the subject based on the output signals; and responsive to detecting concurrent presence of OSA event(s) and EFL: determine one or more OSA event(s) therapy parameters for treating the detected obstructive sleep apnea in the subject; determine one or more EFL therapy parameters for treating the detected expiratory flow limitation in the subject; determine a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters, the priority treatment prioritizing treatment of the detected OSA event(s) over treatment for the detected EFL; and control the pressure generator to deliver the determined priority treatment to the subject. determine one or more OSA event(s) therapy parameters for treating the detected obstructive sleep apnea in the subject; determine one or more EFL therapy parameters for treating the detected expiratory flow limitation in the subject; determine a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters, the priority treatment prioritizing treatment of the detected OSA event(s) over treatment for the detected EFL; and control the pressure generator to deliver the determined priority treatment to the subject.