mhurhangee/ep-ind-claims huggingface dataset:
A compound, or a pharmaceutically-acceptable salt thereof, selected from the group consisting of: 5-(2-ethyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-isopropyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-ethyl-5-methyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-propyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-vinyl-2,3-dihydro-1 H -inden-2-yl)-1 H- imidazole, 5-(2-(prop-1-en-2-yl)-2,3-dihydro-1 H- inden-2-yl)-1 H- imidazole, 5-(2-allyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-butyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2,5-dimethyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole,5-(2-ethyl-5-fluoro-2,3-dihydro-1 H- inden-2-yl)-1 H- imidazole, 5-(5-chloro-2-ethyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 2-(1 H -imidazol-5-yl)-2-methyl-2,3-dihydro-1 H -inden-5-amine, (2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -inden-2-yl)methanol, 1-(2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -inden-2-yl)ethanol, 2-(2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -inden-2-yl)propan-2-ol, 2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -indene-2-carbonitrile, 5-(5-fluoro-2-methyl-2,3-dihydro-1 H -inden-2-yl)-1 H- imidazole, 5-(5,6-dichloro-2-ethyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(5-chloro-2-ethyl-6-fluoro-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(2-ethyl-5,6-difluoro-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 2-ethyl-6-fluoro-2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -inden-5-amine, 5-(2-ethyl-5-nitro-2,3-dihydro-1 H- inden-2-yl)-1 H- imidazole, 5-(2-(methoxymethyl)-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 5-(5-methyl-2,3-dihydro-1 H -inden-2-yl)-1 H -imidazole, 1-(2-(1 H -imidazol-5-yl)-2,3-dihydro-1 H -inden-2-yl)ethanone, 5-(2,3-dihydro-1-methyl-1H-inden-1-yl)-1 H -imidazole, 5-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole, and 5-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-imidazole, for use for producing local or regional anesthesia or analgesia in a nerve or tissue containing an axon or nerve fiber.
An in vitro method of inducing a non-pluripotent human cell into an induced pluripotent stem cell, the method comprising (a) contacting the non-pluripotent human cell with an Oct4 polypeptide and a Klf polypeptide or introducing into the non-pluripotent human cell a polynucleotide encoding an Oct4 polypeptide and a polynucleotide encoding a Klf polypeptide; (b) contacting the non-pluripotent human cell with (i) a compound that promotes glycolytic metabolism, wherein the compound that promotes glycolytic metabolism comprises F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), or a small molecule PDK1 (3'-phosphoinositide-dependent kinase-1) activator; and (ii) a small molecule TGFβ receptor/ALK5 inhibitor, and a small molecule MEK inhibitor, under conditions sufficient to induce the cell to become a pluripotent stem cell, thereby inducing the non-pluripotent human cell to reprogram into an induced pluripotent stem cell. (a) contacting the non-pluripotent human cell with an Oct4 polypeptide and a Klf polypeptide or introducing into the non-pluripotent human cell a polynucleotide encoding an Oct4 polypeptide and a polynucleotide encoding a Klf polypeptide; (b) contacting the non-pluripotent human cell with (i) a compound that promotes glycolytic metabolism, wherein the compound that promotes glycolytic metabolism comprises F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), or a small molecule PDK1 (3'-phosphoinositide-dependent kinase-1) activator; and (ii) a small molecule TGFβ receptor/ALK5 inhibitor, and a small molecule MEK inhibitor, (i) a compound that promotes glycolytic metabolism, wherein the compound that promotes glycolytic metabolism comprises F2,6P (fructose 2,6-bisphosphate), F6P (fructose 6-phosphate), DNP (2,4-dinitrophenol), NOG (N-oxalylglycine), QC (quercetin), 2-HA (2-hydroxyglutaric acid), NA (nicotinic acid), or a small molecule PDK1 (3'-phosphoinositide-dependent kinase-1) activator; and (ii) a small molecule TGFβ receptor/ALK5 inhibitor, and a small molecule MEK inhibitor,
Thermal actuator including at least two extensible elements (12, 14, 16), which elements are capable of undergoing an increase in length in a direction of force application (XX'), under the effect of an increase in temperature, and vice versa, and at least one invariant element (13, 15), which element is capable of undergoing an increase in length that is much smaller than the increase in length of the extensible element, or even no increase in length, under the effect of said increase in temperature, each invariant element (13, 15) being bonded to and intercalated between two extensible elements (12, 14, 16), characterized in that the invariant element (13, 15) includes, at a first longitudinal end (133, 153), a collar, referred to as the inner collar (131, 151), extending radially inwards towards an interior of the actuator, and at an opposite longitudinal end (134, 154), a collar, referred to as the outer collar (132, 152), extending radially outwards towards an exterior of the actuator.
Method for controlling the temperature of rooms in a building in which a voltage source is arranged, in which method a heating circuit distributor is installed in the building, which heating circuit distributor has a controller and a number of valves which corresponds to the number of heating circuits present in the building, in each case one of which valves is incorporated in a feed line for a heating or cooling medium of a heating circuit, in which method each valve is equipped with an actuating drive by way of which the position of the valve, which position determines the throughflow of the heating or cooling medium, between an open position and a closed position as end positions is adjusted, and in which method an actuating drive which is equipped with an electric motor is used as the actuating drive for each of the valves, characterized - in that the motors of all of the actuating drives are each, individually and at separate times from one another, connected to the voltage source with the proviso that always only the motor of a single actuating drive is connected to the voltage source by the controller for a prespecified period of time for the purpose of operating a valve and, after the period of time has elapsed, is disconnected from the voltage source while maintaining the respective position as a stable position, and - in that the motors of all of the actuating drives are equipped with a self-locking gear mechanism for the purpose of converting the rotational movement of the rotors, which are equipped with a shaft, of the motors into a translatory movement. - in that the motors of all of the actuating drives are each, individually and at separate times from one another, connected to the voltage source with the proviso that always only the motor of a single actuating drive is connected to the voltage source by the controller for a prespecified period of time for the purpose of operating a valve and, after the period of time has elapsed, is disconnected from the voltage source while maintaining the respective position as a stable position, and - in that the motors of all of the actuating drives are equipped with a self-locking gear mechanism for the purpose of converting the rotational movement of the rotors, which are equipped with a shaft, of the motors into a translatory movement.
A back panel device for installation in a vehicle used for public transportation, comprising: - a back panel including a front side for supporting a wheelchair user; - a securing device for securing the back panel device in the passenger compartment of a vehicle; and - a pivot arm by way of which the back panel is pivotably hinged on the securing device, the back panel being pivotable about a horizontal pivot axis in the installation position of the back panel device, characterized in that the back panel can be pivoted with the front side in the direction of travel (F, F') or with the front side counter to the direction of travel (F, F'). - a back panel including a front side for supporting a wheelchair user; - a securing device for securing the back panel device in the passenger compartment of a vehicle; and - a pivot arm by way of which the back panel is pivotably hinged on the securing device, the back panel being pivotable about a horizontal pivot axis in the installation position of the back panel device,
Packaging for the transport and handling of elongated elements such as watch hands including elongated elements at least one support having a face for receiving the elongated elements and a means of fixing said elongated elements, said support being characterized in that the fixing means is at least one bead of adhesive material of sufficient height to hold the elongated element at a distance from the receiving face.
A supercontinuum radiation source comprising: a modulator (Mod) being operable to modulate pump laser radiation comprising a train of radiation pulses to provide modulated pump laser radiation (B mod), said modulation being such to selectively provide a burst of said pulses; and a hollow-core photonic crystal fiber (HC-PCF) being operable to receive the modulated pump laser radiation and excite a working medium contained within the hollow-core photonic crystal fiber so as to generate supercontinuum radiation (B out). a modulator (Mod) being operable to modulate pump laser radiation comprising a train of radiation pulses to provide modulated pump laser radiation (B mod), said modulation being such to selectively provide a burst of said pulses; and a hollow-core photonic crystal fiber (HC-PCF) being operable to receive the modulated pump laser radiation and excite a working medium contained within the hollow-core photonic crystal fiber so as to generate supercontinuum radiation (B out).
A method of image processing comprising correcting an image on an area-by-area basis to generate an output image intensity (O ij) of an area which is different to an input image intensity (I ij) of the area, the output image intensity (O ij) of an area being related to the input image intensity (I ij) of the area by: O ij = amplification coefficient × I ij wherein the method comprises: using a non-linear image transform (122,124) to generate an amplification coefficient of a given area relative to the input image intensity (I ij), where the non-linear transform is a transform which alters the dynamic range of the image; applying an erosion procedure to vary the amplification coefficient of the given area to be closer to a minimum amplification coefficient of a set of neighbouring areas, the set comprising the given area; and generating an output image intensity (O ij) of the given area using the varied amplification coefficient, whereby to at least partially preserve, in at least part of the image, the local contrast of the input image in the output image. using a non-linear image transform (122,124) to generate an amplification coefficient of a given area relative to the input image intensity (I ij), where the non-linear transform is a transform which alters the dynamic range of the image; applying an erosion procedure to vary the amplification coefficient of the given area to be closer to a minimum amplification coefficient of a set of neighbouring areas, the set comprising the given area; and generating an output image intensity (O ij) of the given area using the varied amplification coefficient, whereby to at least partially preserve, in at least part of the image, the local contrast of the input image in the output image.
Sole for a sports shoe, notably for a cross-country ski boot, comprising a first component acting as a framework and at least one second component assembled with the first component, characterized in that the second component comprises an anterior part extending substantially longitudinally in an anterior part of the sole and in that the anterior part of the second component of the sole extends between two lateral parts of the anterior part of the first component and/or at least partially between two lateral rows of anterior studs of the first component of the sole.
A device for producing transformer cores, the device comprising a retaining system having a stacking table (18, 33, 52) for collecting sheets of metal (16, 35) from which a transformer core is formed and having at least two positioning aids (20, 32, 50) for the sheets of metal, the stacking table forming a positioning surface (26, 37, 51) for the positioning aids and being equipped with the positioning aids, characterized in that the stacking table and the positioning aids are realized such that free positioning and location-independent fastening of the positioning aids within the positioning surface is possible, the device having a positioning system by means of which the positioning aids can be disposed on and/or be removed from the stacking table.
A method of implementing geofencing using a mobile device having a GPS capability, the mobile device configured to be operably coupled to a building controller, the method comprising: setting a geofence defining a region about a building; turning on the GPS capability of the mobile device, ascertain an updated current location of the mobile device, and then turning off the GPS capability; determining a position of the mobile device relative to the geofence based on the updated current location; calculating a time to fence value, wherein the time to fence value is an estimate of a minimum length of time it would take for an individual carrying the mobile device to cross the geofence; calculating a delay time value, where the delay time value is based at least in part on the calculated time to fence value and is less than the time to fence value; with the GPS capability turned off, waiting the delay time value and then: turning on the GPS capability of the mobile device; ascertaining an updated current location of the mobile device; turning off the GPS capability; repeating the determining the position, calculating the time to fence value, calculating the delay time value, waiting the delay time value, turning on the GPS capability, ascertaining an updated current location, and turning off the GPS capability steps; and transmitting the time to fence value to the building controller so that the building controller can regulate operation of a building system in accordance with the time to fence value. setting a geofence defining a region about a building; turning on the GPS capability of the mobile device, ascertain an updated current location of the mobile device, and then turning off the GPS capability; determining a position of the mobile device relative to the geofence based on the updated current location; calculating a time to fence value, wherein the time to fence value is an estimate of a minimum length of time it would take for an individual carrying the mobile device to cross the geofence; calculating a delay time value, where the delay time value is based at least in part on the calculated time to fence value and is less than the time to fence value; with the GPS capability turned off, waiting the delay time value and then: turning on the GPS capability of the mobile device; ascertaining an updated current location of the mobile device; turning off the GPS capability; turning on the GPS capability of the mobile device; ascertaining an updated current location of the mobile device; turning off the GPS capability; repeating the determining the position, calculating the time to fence value, calculating the delay time value, waiting the delay time value, turning on the GPS capability, ascertaining an updated current location, and turning off the GPS capability steps; and transmitting the time to fence value to the building controller so that the building controller can regulate operation of a building system in accordance with the time to fence value.
A method for producing particles, the method comprising: applying vibration to a liquid including a physiologically active substance and included in a liquid-column resonance liquid-chamber to form a standing wave based on liquid column resonance, to thereby discharge the liquid from at least one discharging port, which is formed in an amplitude direction of the standing wave, to at least one region corresponding to at least one anti-node of the standing wave; and drying the liquid discharged, to thereby form particles containing a physiologically active substance, wherein the physiologically active substance is a pharmaceutical compound. applying vibration to a liquid including a physiologically active substance and included in a liquid-column resonance liquid-chamber to form a standing wave based on liquid column resonance, to thereby discharge the liquid from at least one discharging port, which is formed in an amplitude direction of the standing wave, to at least one region corresponding to at least one anti-node of the standing wave; and drying the liquid discharged, to thereby form particles containing a physiologically active substance, wherein the physiologically active substance is a pharmaceutical compound.
A process for the manufacture of a compound, or salt thereof, of formula which comprises the reduction of a compound of formula, or salt thereof, for obtaining a compound, or salt thereof, of formula and converting the compound, or salt thereof, of formula to the compound, or salt thereof, of formula.
A medical system, comprising a. a housing; b. a preassembled functional module received in the housing, the preassembled functional module comprising b1. an analytical sensor for detecting at least one analyte in a body fluid of a user; b2. an electronics unit electrically connected to the analytical sensor; b3. an insertion component for inserting the analytical sensor into a body tissue of the user; and b4. at least one sterility cap at least partially surrounding the insertion component; c. at least one removable protective cap connected to the housing, covering the preassembled functional module; wherein the sterility cap is configured for being pulled off from the insertion component when the protective cap is pulled off from the housing, wherein the sterility cap is connected to the protective cap at a distal end of the sterility cap by one or more of a form-fit connection, a force-fit connection. a. a housing; b. a preassembled functional module received in the housing, the preassembled functional module comprising b1. an analytical sensor for detecting at least one analyte in a body fluid of a user; b2. an electronics unit electrically connected to the analytical sensor; b3. an insertion component for inserting the analytical sensor into a body tissue of the user; and b4. at least one sterility cap at least partially surrounding the insertion component; b1. an analytical sensor for detecting at least one analyte in a body fluid of a user; b2. an electronics unit electrically connected to the analytical sensor; b3. an insertion component for inserting the analytical sensor into a body tissue of the user; and b4. at least one sterility cap at least partially surrounding the insertion component; c. at least one removable protective cap connected to the housing, covering the preassembled functional module;
A method for preparing taurine, wherein in a production process of taurine by an ethylene oxide method, isethionate and ammonia are subjected to an ammonolysis reaction under a microwave condition.
A circulating hot water system with a hot water flow circuit defined by pipework leading out from and back to a heater, the system including the heater and a pump to drive circulation of hot water in the flow circuit; the heater being operable to act on the flow circuit to heat water flowing therein and having a heat output which is controllably variable, and the system comprising multiple user points on the flow circuit, at least some of the user points being outlet user points where an outlet can be opened to take hot water out of the system, the hot water flow circuit having a main flow circuit and a branch from the main flow circuit leading to a said outlet user point; characterised in that the branch comprises an outflow branch conduit and a return flow branch conduit, branch circulation being provided by communication, adjacent to the outlet user point, between the outflow branch conduit and the return flow branch conduit, the branch return flow conduit returning to the main flow circuit, and in that the system comprises a shut-off or flow restrictor, operable when hot water is taken out at a said outlet user point to stop or restrict return flow back to the heater in a return conduit of the flow circuit. the heater being operable to act on the flow circuit to heat water flowing therein and having a heat output which is controllably variable, and the system comprising multiple user points on the flow circuit, at least some of the user points being outlet user points where an outlet can be opened to take hot water out of the system, the hot water flow circuit having a main flow circuit and a branch from the main flow circuit leading to a said outlet user point; characterised in that the branch comprises an outflow branch conduit and a return flow branch conduit, branch circulation being provided by communication, adjacent to the outlet user point, between the outflow branch conduit and the return flow branch conduit, the branch return flow conduit returning to the main flow circuit, and in that the system comprises a shut-off or flow restrictor, operable when hot water is taken out at a said outlet user point to stop or restrict return flow back to the heater in a return conduit of the flow circuit.
Electromotive furniture drive having at least one adjusting drive (7, 8) for the electromotive adjustment of at least one movable furniture part relative to further furniture parts and a control device for actuating the at least one adjusting drive (7, 8), wherein the at least one adjusting drive (7, 8) is supplied with an operating voltage between 24 and 30 V, and a charging apparatus having at least one charging connection for supplying power to an external electronic device, wherein the charging apparatus has a cable for connection to the control device and wherein the voltage provided at the at least one charging connection is 5V, wherein the cable leads from the control device to a voltage converter to which the at least one charging connection is connected, wherein the cable is supplied by the control device with the operating voltage is also provided to the at least one adjusting drive (7, 8).
An apparatus comprising: a wire retaining tray comprising at least one outlet; one or more springs; and a plurality of wire retainers, wherein the plurality of wire retainers are coupled together and coupled to the one or more springs and at least one of the at least one outlet of the wire retaining tray, wherein the one or more springs are adapted to exert a force on one or more wire retainers to position the wire retainers relative to the wire retaining tray and wherein at least one of the wire retainers comprises a wire holding mechanism configured to hold at least a portion of a wire in a substantially straight orientation. a wire retaining tray comprising at least one outlet; one or more springs; and a plurality of wire retainers, wherein the plurality of wire retainers are coupled together and coupled to the one or more springs and at least one of the at least one outlet of the wire retaining tray, wherein the one or more springs are adapted to exert a force on one or more wire retainers to position the wire retainers relative to the wire retaining tray and wherein at least one of the wire retainers comprises a wire holding mechanism configured to hold at least a portion of a wire in a substantially straight orientation.