A method of making a compound of Formula or, comprising the steps of: (a) reacting a compound of Formula and R 1 R 2 -NH to form a compound of Formula: (b) reacting a compound of Formula with an compound of Formula, in the presence of acid and a phase transfer catalyst, to form a compound of Formula: and (c) subjecting a compound of Formula to reducing conditions to form a compound of Formula: or a compound of Formula: wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted C 6 or C 10 aryl, optionally substituted 5 to 10 membered heteroaryl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, optionally substituted amido, and a suitable amine protecting group; and R 3 is selected from the group consisting of optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, and optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, the method is carried out at a temperature of at least at least 0°C, at least 10°C, at least 20°C, at least 30°C, at least 40°C, at least 50°C, at least 60°C, at least 70°C, at least 80°C, at least 90°C, at least 100°C, at least 110°C, at least 120°C, at least 130°C, at least 140°C, at least 150°C, at least 160°C, at least 170°C, or at least 180°C. (a) reacting a compound of Formula and R 1 R 2 -NH to form a compound of Formula: (b) reacting a compound of Formula with an compound of Formula, in the presence of acid and a phase transfer catalyst, to form a compound of Formula: and (c) subjecting a compound of Formula to reducing conditions to form a compound of Formula: or a compound of Formula: wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted C 6 or C 10 aryl, optionally substituted 5 to 10 membered heteroaryl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, optionally substituted amido, and a suitable amine protecting group; and R 3 is selected from the group consisting of optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, and optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, the method is carried out at a temperature of at least at least 0°C, at least 10°C, at least 20°C, at least 30°C, at least 40°C, at least 50°C, at least 60°C, at least 70°C, at least 80°C, at least 90°C, at least 100°C, at least 110°C, at least 120°C, at least 130°C, at least 140°C, at least 150°C, at least 160°C, at least 170°C, or at least 180°C. R 1 and R 2 are independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted C 6 or C 10 aryl, optionally substituted 5 to 10 membered heteroaryl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, optionally substituted amido, and a suitable amine protecting group; and R 3 is selected from the group consisting of optionally substituted C 1 -C 24 alkyl, optionally substituted C 2 -C 24 alkenyl, optionally substituted C 2 -C 24 alkynyl, optionally substituted 5 to 10 membered heterocyclyl, optionally substituted C 7-13 aralkyl, optionally substituted (5 to 10 membered heteroaryl)-C 1 -C 6 alkyl, optionally substituted C 3-10 carbocyclyl, optionally substituted C 4-10 (carbocyclyl)alkyl, and optionally substituted (5 to 10 membered heterocyclyl)-C 1 -C 6 alkyl, the method is carried out at a temperature of at least at least 0°C, at least 10°C, at least 20°C, at least 30°C, at least 40°C, at least 50°C, at least 60°C, at least 70°C, at least 80°C, at least 90°C, at least 100°C, at least 110°C, at least 120°C, at least 130°C, at least 140°C, at least 150°C, at least 160°C, at least 170°C, or at least 180°C.