mhurhangee/ep-ind-claims huggingface dataset:
An antibody or binding fragment thereof comprising: an antibody heavy chain variable region comprising a sequence of the formula V1-X-V2, wherein: (a) V1 comprises an amino acid sequence selected from the group consisting of: (i) SEQ ID NO: 735, (ii) SEQ ID NO: 737, (iii) SEQ ID NO: 739, (vi) SEQ ID NO: 741, (v) SEQ ID NO: 743, (vi) SEQ ID NO: 745, (vii) SEQ ID NO 747, and (viii) SEQ ID NO:749; and (b) X comprises an ultralong CDR3, wherein the ultralong CDR3 comprises, in this order, an amino acid sequence TSVHQETKKYQS (SEQ ID NO: 498), a non-antibody sequence, wherein the non-antibody sequence is a cytokine sequence, a lymphokine sequence, a chemokine sequence, a growth factor sequence, a hormone sequence or a toxin sequence, and an amino acid sequence SYTYNYEWHVDV (SEQ ID NO: 499); and wherein the ultralong CDR3 is 35 amino acids in length or longer, and (c) V2 comprises an amino acid sequence that is WGQGLLVTVSS (SEQ ID NO: 500); and a light chain variable region. an antibody heavy chain variable region comprising a sequence of the formula V1-X-V2, wherein: (a) V1 comprises an amino acid sequence selected from the group consisting of: (i) SEQ ID NO: 735, (ii) SEQ ID NO: 737, (iii) SEQ ID NO: 739, (vi) SEQ ID NO: 741, (v) SEQ ID NO: 743, (vi) SEQ ID NO: 745, (vii) SEQ ID NO 747, and (viii) SEQ ID NO:749; and (b) X comprises an ultralong CDR3, wherein the ultralong CDR3 comprises, in this order, an amino acid sequence TSVHQETKKYQS (SEQ ID NO: 498), a non-antibody sequence, wherein the non-antibody sequence is a cytokine sequence, a lymphokine sequence, a chemokine sequence, a growth factor sequence, a hormone sequence or a toxin sequence, and an amino acid sequence SYTYNYEWHVDV (SEQ ID NO: 499); and wherein the ultralong CDR3 is 35 amino acids in length or longer, and (c) V2 comprises an amino acid sequence that is WGQGLLVTVSS (SEQ ID NO: 500); and (a) V1 comprises an amino acid sequence selected from the group consisting of: (i) SEQ ID NO: 735, (ii) SEQ ID NO: 737, (iii) SEQ ID NO: 739, (vi) SEQ ID NO: 741, (v) SEQ ID NO: 743, (vi) SEQ ID NO: 745, (vii) SEQ ID NO 747, and (viii) SEQ ID NO:749; and (i) SEQ ID NO: 735, (ii) SEQ ID NO: 737, (iii) SEQ ID NO: 739, (vi) SEQ ID NO: 741, (v) SEQ ID NO: 743, (vi) SEQ ID NO: 745, (vii) SEQ ID NO 747, and (viii) SEQ ID NO:749; and (b) X comprises an ultralong CDR3, wherein the ultralong CDR3 comprises, in this order, an amino acid sequence TSVHQETKKYQS (SEQ ID NO: 498), a non-antibody sequence, wherein the non-antibody sequence is a cytokine sequence, a lymphokine sequence, a chemokine sequence, a growth factor sequence, a hormone sequence or a toxin sequence, and an amino acid sequence SYTYNYEWHVDV (SEQ ID NO: 499); and wherein the ultralong CDR3 is 35 amino acids in length or longer, and (c) V2 comprises an amino acid sequence that is WGQGLLVTVSS (SEQ ID NO: 500); and a light chain variable region.
An exhaust gas processing apparatus (100, 110) that processes exhaust gas, comprising: a reaction tower in which the exhaust gas introduced by an exhaust gas introducing pipe moves upward while being circulated; a trunk tube that is provided in a height direction inside the reaction tower and is supplied with a liquid for processing the exhaust gas by a cleaning liquid supply pump; and a plurality of ejecting sections that are configured to eject, along with a circulating direction of the exhaust gas, the liquid supplied from the trunk tube, wherein the plurality of ejecting sections are provided at different positions in the height direction of the reaction tower from a bottom portion side where the exhaust gas is introduced to a top portion side where the exhaust gas is emitted, and a volume flow rate of the liquid ejected from the ejecting sections on the top portion side is less than a volume (or volumetric) flow rate of the liquid ejected from the ejecting sections on the bottom portion side, wherein the volume flow rate of the liquid ejected by the plurality of ejecting sections becomes smaller in order from the bottom portion side to the top portion side; and a particle diameter of the liquid ejected by the ejecting sections becomes small in order from the bottom portion side to the top portion side. a reaction tower in which the exhaust gas introduced by an exhaust gas introducing pipe moves upward while being circulated; a trunk tube that is provided in a height direction inside the reaction tower and is supplied with a liquid for processing the exhaust gas by a cleaning liquid supply pump; and a plurality of ejecting sections that are configured to eject, along with a circulating direction of the exhaust gas, the liquid supplied from the trunk tube, wherein the plurality of ejecting sections are provided at different positions in the height direction of the reaction tower from a bottom portion side where the exhaust gas is introduced to a top portion side where the exhaust gas is emitted, and a volume flow rate of the liquid ejected from the ejecting sections on the top portion side is less than a volume (or volumetric) flow rate of the liquid ejected from the ejecting sections on the bottom portion side, wherein the volume flow rate of the liquid ejected by the plurality of ejecting sections becomes smaller in order from the bottom portion side to the top portion side; and a particle diameter of the liquid ejected by the ejecting sections becomes small in order from the bottom portion side to the top portion side.
An electrical connector system, comprising: a plug including a conductive shell having a housing positioned therein; the housing having a plurality of electrical contacts including a ground contact internally wired to the shell via a jumper; the electrical contacts including sleeves extending from the housing; and a monitor circuit positioned in the housing and configured to determine continuity between the shell and the ground contact by measuring a voltage between the shell and the ground contact; the monitor circuit including an output connected to an indicator (210, 212; 214) that is configured to output an indicator signal in response to the continuity determination. a plug including a conductive shell having a housing positioned therein; the housing having a plurality of electrical contacts including a ground contact internally wired to the shell via a jumper; the electrical contacts including sleeves extending from the housing; and a monitor circuit positioned in the housing and configured to determine continuity between the shell and the ground contact by measuring a voltage between the shell and the ground contact; the monitor circuit including an output connected to an indicator (210, 212; 214) that is configured to output an indicator signal in response to the continuity determination.
A method of manufacturing an intravascular blood pump, the blood pump comprising a pumping device including an impeller and an electric motor for driving the impeller, the electric motor including a stator and a rotor, the rotor rotatable about an axis of rotation and coupled to the impeller so as to be able to cause rotation of the impeller, the method comprising the steps of: - providing a molding base sized and shaped for receiving stator components thereon; - placing the stator components on the molding base; - placing an outer sleeve on the molding base to thereby form at least a portion of an outer surface of the blood pump and an interspace between the molding base and the outer sleeve in which the stator components are disposed; and - injecting a casting compound into the interspace via the molding base to fix the stator components inside the outer sleeve. - providing a molding base sized and shaped for receiving stator components thereon; - placing the stator components on the molding base; - placing an outer sleeve on the molding base to thereby form at least a portion of an outer surface of the blood pump and an interspace between the molding base and the outer sleeve in which the stator components are disposed; and - injecting a casting compound into the interspace via the molding base to fix the stator components inside the outer sleeve.
Isolated nanoparticles comprising octapod iron oxide, wherein the octapod iron oxide is composed of magnetite and chloride ions, wherein the chloride-containing octapod iron oxide has a shape characterized by eight trigonal bipyramidal arms, a concave polyhedral geometry bounded by high-index facets, 14 facets in total, and 24 edges, and wherein the chloride ions are chelated to Fe ions exposed on the facets.
An oscillating heat pipe comprising: a channel configured to enable flow of working fluid between at least one condenser region 103 and at least one evaporator region 105; characterized in that the oscillating pipe further comprises: at least one wick structure in fluidic connection with the channel so as to enable working fluid to flow from the channel into the wick structure; and at least one vent configured to enable working fluid in an, at least partial, vapour phase to be returned from the wick structure to the channel. at least one wick structure in fluidic connection with the channel so as to enable working fluid to flow from the channel into the wick structure; and at least one vent configured to enable working fluid in an, at least partial, vapour phase to be returned from the wick structure to the channel.
System for bonding at least one wet-laid or dry-laid fiber layer to form a nonwoven web, having a conveyor which comprises a circulating belt with an upper strand on which the at least one fiber layer can be deposited and displaced in a production direction, having a first bonding device, by means of which the fiber layer can be bonded while it is on the upper strand, and having a second bonding device, by means of which the fiber layer can additionally be bonded after leaving the upper strand, characterized in that the system comprises a transfer device by means of which the fiber layer can optionally be fed to the second bonding device. having a conveyor which comprises a circulating belt with an upper strand on which the at least one fiber layer can be deposited and displaced in a production direction, having a first bonding device, by means of which the fiber layer can be bonded while it is on the upper strand, and having a second bonding device, by means of which the fiber layer can additionally be bonded after leaving the upper strand, characterized in that the system comprises a transfer device by means of which the fiber layer can optionally be fed to the second bonding device.
An optical assembly comprising an optical instrument and a device for passively reducing pollution of an optical access of said optical instrument located in a polluting environment, characterised in that the device for passively reducing pollution includes a part provided with: - a channel provided in said part and having a first end open outwardly of the part so as to lead into the polluting environment, said channel having a substantially rectilinear axis (X-X) and a mean general diameter d; and - a cavity provided in said part at a second end of the channel, opposite to said first end, said second end of the channel leading into the cavity, said cavity having an open end opposite to said second end of the channel, said cavity having a mean general diameter D, the ratio of the mean general diameter D to the mean general diameter d being greater than or equal to: 2, the assembly being configured to receive a radiation from upstream to downstream from the polluting environment along a penetration direction and the optical instrument being arranged downstream of the part and facing the open end of the cavity to receive the radiation which passes from upstream to downstream through the channel and the cavity by penetrating the part from the first end of the channel and coming out of the part by the open end of the cavity. - a channel provided in said part and having a first end open outwardly of the part so as to lead into the polluting environment, said channel having a substantially rectilinear axis (X-X) and a mean general diameter d; and - a cavity provided in said part at a second end of the channel, opposite to said first end, said second end of the channel leading into the cavity, said cavity having an open end opposite to said second end of the channel, said cavity having a mean general diameter D, the ratio of the mean general diameter D to the mean general diameter d being greater than or equal to: 2,
An exhaust purification system for an internal combustion engine, comprising: an exhaust purification catalyst provided in an exhaust passage of the internal combustion engine in a vehicle; a fuel supply device which is provided in the exhaust passage upstream the exhaust purification catalyst and supplies fuel to an exhaust gas flowing into the exhaust purification catalyst; a heating device which heats the fuel supplied from the fuel supply device; and a controller which comprises means for controlling the heating device, characterized in that the controller controls the heating device to a pre-heating temperature lower than an ignition threshold value (Ti) capable of igniting the fuel by supplying power to the heating device without performing fuel supply by the fuel supply device when a first processing request, which stands if a state of the exhaust purification catalyst requires combustion of the fuel, is standing and a second processing request, which stands if an operating state of the vehicle allows exhaust oxygen concentration suitable for combustion of the fuel to be supplied, is not standing, and controls the heating device to an ignition temperature higher than the ignition threshold value (Ti) when the first processing request and the second processing request are standing and controls the fuel supply device so that the fuel is supplied on condition that the heating device has reached the ignition temperature. an exhaust purification catalyst provided in an exhaust passage of the internal combustion engine in a vehicle; a fuel supply device which is provided in the exhaust passage upstream the exhaust purification catalyst and supplies fuel to an exhaust gas flowing into the exhaust purification catalyst; a heating device which heats the fuel supplied from the fuel supply device; and a controller which comprises means for controlling the heating device, characterized in that the controller controls the heating device to a pre-heating temperature lower than an ignition threshold value (Ti) capable of igniting the fuel by supplying power to the heating device without performing fuel supply by the fuel supply device when a first processing request, which stands if a state of the exhaust purification catalyst requires combustion of the fuel, is standing and a second processing request, which stands if an operating state of the vehicle allows exhaust oxygen concentration suitable for combustion of the fuel to be supplied, is not standing, and controls the heating device to an ignition temperature higher than the ignition threshold value (Ti) when the first processing request and the second processing request are standing and controls the fuel supply device so that the fuel is supplied on condition that the heating device has reached the ignition temperature.
Tablet press, having a turning unit comprising at least one die for forming the tablet, a drive unit which allows the turning unit to rotate station by station between individual processing positions, and at least one lower punch, wherein the lower punch is rotatably disposed in the die with the turning unit, wherein the tablet press further comprises a pressing force generating unit, characterised in that the pressing force generating unit is disposed below the turning unit, wherein the pressing force generating unit comprises a pressure cylinder which pulls an upper punch towards the lower punch during pressing.
A method of performing a routine maintenance procedure in respect of a wheel of an aircraft landing gear (12; 14), wherein the wheel comprises a tyre and consumable brake lining material, and the method comprises re-treading or replacing the tyre at successive intervals as part of the routine maintenance procedure, and characterised by inspecting or replacing the consumable brake lining material at the same successive intervals (1012; 1018; 1020; 1022). the wheel comprises a tyre and consumable brake lining material, and the method comprises re-treading or replacing the tyre at successive intervals as part of the routine maintenance procedure, and characterised by inspecting or replacing the consumable brake lining material at the same successive intervals (1012; 1018; 1020; 1022). re-treading or replacing the tyre at successive intervals as part of the routine maintenance procedure, and characterised by inspecting or replacing the consumable brake lining material at the same successive intervals (1012; 1018; 1020; 1022).
A method for extracting DNA from seeds, said method comprising: a. pretreating said seeds by soaking the seeds in a pretreatment solution comprising: i. an alkali in a concentration sufficient to soften said seed and ii. an osmoticum at a concentration of between about 1M and 5M; b. crushing said seeds; c. extracting said DNA from said crushed seeds and wherein said osmoticum is selected from the group consisting of sodium chloride, potassium chloride, polyethylene glycol, mannitol, sugar alcohols, and sucrose. a. pretreating said seeds by soaking the seeds in a pretreatment solution comprising: i. an alkali in a concentration sufficient to soften said seed and ii. an osmoticum at a concentration of between about 1M and 5M; i. an alkali in a concentration sufficient to soften said seed and ii. an osmoticum at a concentration of between about 1M and 5M; b. crushing said seeds; c. extracting said DNA from said crushed seeds
Device for stabilising a porous soil, the said device comprising: - a part forming a watertight tank which is intended to rest on a surface and to accommodate the said soil, the said part forming a tank comprising four sides and a bottom through which at least one perforation passes; and - an excess water conduit which forms a siphon comprising an inlet which is connected to the said at least one perforation, characterised in that the conduit comprises a portion which extends essentially vertically and the outlet of which discharges above the level of the said bottom and below the upper level of the said soil. - a part forming a watertight tank which is intended to rest on a surface and to accommodate the said soil, the said part forming a tank comprising four sides and a bottom through which at least one perforation passes; and - an excess water conduit which forms a siphon comprising an inlet which is connected to the said at least one perforation,
Machine tool for the processing and handling of plate-shaped workpieces with a machine table comprising at least two longitudinal frame modules and at least two cross frame modules, wherein each longitudinal frame module is connected to the at least two cross frame modules by fastening means and each longitudinal frame module comprises an upper flange and a lower flange, which are formed from metallic profiles, for example pipes, and which are connected to one another via spaced posts, wherein a guide rail for the movable mounting of a tool is supported on at least one upper flange, characterised in that on each longitudinal frame module the posts are welded to the upper flange and the lower flange and each longitudinal frame module is connected to at least two cross frame modules via mechanical fastening means for forming a rack of the machine table of the machine tool.
Assembly comprising: - an electrical machine which isopen at a longitudinal end and comprises: - a stator having windings which form coils, - a rotor, - a shaft rotating the rotor, - an impeller for cooling the electrical machine, said cooling impeller comprising at least two crowns (2, 21, 22), including a first crown and a second crown, each crown (2, 21, 22) comprising blades, wherein the blades (3, 31) of the first crown of the cooling impeller are arranged so as to generate a circulation of a cooling fluid flow in a first direction in which the flow travels parallel to a rotation axis of the rotor and away from the impeller, and the blades (3, 32) of the second crown are arranged so as to generate the circulation of the cooling fluid flow in a second direction, the second direction being opposite the first direction,with a flow outside the electrical machine entering via the cooling impeller and a flow inside the electrical machine exiting via the impeller. - an electrical machine which isopen at a longitudinal end and comprises: - a stator having windings which form coils, - a rotor, - a shaft rotating the rotor, - an impeller for cooling the electrical machine, said cooling impeller comprising at least two crowns (2, 21, 22), including a first crown and a second crown, each crown (2, 21, 22) comprising blades, - a stator having windings which form coils, - a rotor, - a shaft rotating the rotor, - an impeller for cooling the electrical machine, said cooling impeller comprising at least two crowns (2, 21, 22), including a first crown and a second crown, each crown (2, 21, 22) comprising blades,
A consolidated thermal module for securing and cooling an integrated circuit mounted to a printed circuit board, the CTM comprising: a heat removal assembly, the heat removal assembly disposed on a first surface of the PCB and in thermal contact with the IC; a retaining mechanism disposed on a second surface of the PCB; a backer plate disposed between the retaining mechanism and the PCB; and a fastener that secures the heat removal assembly to the backer plate and the retaining mechanism; characterized in that: the retaining mechanism comprises a leaf spring which applies a substantially uniform retaining force in a first direction to the backer plate thereby minimizing an amount of torque applied to the IC; wherein the heat removal assembly further comprises: a thermally conductive casting having fastener attachment points that secure the thermally conductive casting to the retaining mechanism; and a thermally conductive slug that provides a force to the IC in a second direction opposite to the first direction. a heat removal assembly, the heat removal assembly disposed on a first surface of the PCB and in thermal contact with the IC; a retaining mechanism disposed on a second surface of the PCB; a backer plate disposed between the retaining mechanism and the PCB; and a fastener that secures the heat removal assembly to the backer plate and the retaining mechanism; the retaining mechanism comprises a leaf spring which applies a substantially uniform retaining force in a first direction to the backer plate thereby minimizing an amount of torque applied to the IC; wherein the heat removal assembly further comprises: a thermally conductive casting having fastener attachment points that secure the thermally conductive casting to the retaining mechanism; and a thermally conductive slug that provides a force to the IC in a second direction opposite to the first direction. a thermally conductive casting having fastener attachment points that secure the thermally conductive casting to the retaining mechanism; and a thermally conductive slug that provides a force to the IC in a second direction opposite to the first direction.