A polyp removal device, comprising: an outer tubular body having proximal and distal ends; an inner tubular body positioned within a lumen of the outer tubular body, the inner tubular body having proximal and distal ends and being movable with respect to the outer tubular body; a handle (102, 202, 1802, 1902, 2002) coupled to the proximal end of the outer tubular body; an actuation member movably coupled to the handle, the actuation member configured to cause at least translation of the inner tubular body with respect to the outer tubular body when the actuation member is moved with respect to the handle; a vacuum port for coupling thereto of a vacuum source, the vacuum port being in fluid communication with a lumen of the inner tubular body; an opening near a distal end of the polyp removal device, the opening configured to allow fluid communication between an environment external to the polyp removal device and the lumen of the inner tubular body; a cutting block (2060, 1160, 2560) positioned at the distal end of the outer tubular body and at least partially distal to the opening, the cutting block comprising a blunt rounded distal portion that at least partially forms a distal tip of the polyp removal device, the cutting block further comprising a proximally extending cutting portion positioned within the lumen of the outer tubular body, the cutting portion comprising a cylindrical outer surface,; and a tubular cutter positioned at the distal end of the inner tubular body, the tubular cutter sized to fit at least partially within an annular shaped void between the lumen of the outer tubular body and the cylindrical outer surface of the cutting portion of the cutting block when the inner tubular body is in an extended position with respect to the outer tubular body, characterised in that the cutting portion further comprises a concave proximal face, and a cutting edge where the cylindrical outer surface meets the concave proximal face. an outer tubular body having proximal and distal ends; an inner tubular body positioned within a lumen of the outer tubular body, the inner tubular body having proximal and distal ends and being movable with respect to the outer tubular body; a handle (102, 202, 1802, 1902, 2002) coupled to the proximal end of the outer tubular body; an actuation member movably coupled to the handle, the actuation member configured to cause at least translation of the inner tubular body with respect to the outer tubular body when the actuation member is moved with respect to the handle; a vacuum port for coupling thereto of a vacuum source, the vacuum port being in fluid communication with a lumen of the inner tubular body; an opening near a distal end of the polyp removal device, the opening configured to allow fluid communication between an environment external to the polyp removal device and the lumen of the inner tubular body; a cutting block (2060, 1160, 2560) positioned at the distal end of the outer tubular body and at least partially distal to the opening, the cutting block comprising a blunt rounded distal portion that at least partially forms a distal tip of the polyp removal device, the cutting block further comprising a proximally extending cutting portion positioned within the lumen of the outer tubular body, the cutting portion comprising a cylindrical outer surface,; and a tubular cutter positioned at the distal end of the inner tubular body, the tubular cutter sized to fit at least partially within an annular shaped void between the lumen of the outer tubular body and the cylindrical outer surface of the cutting portion of the cutting block when the inner tubular body is in an extended position with respect to the outer tubular body, characterised in that the cutting portion further comprises a concave proximal face, and a cutting edge where the cylindrical outer surface meets the concave proximal face.