An electroporation therapy apparatus, comprising: an electroporation generator, wherein the electroporation generator is configured to output an asymmetric balanced waveform to a medical device comprising an electrode assembly comprising a circular catheter having a plurality of electrode elements disposed on the circular catheter, wherein the asymmetric balanced waveform comprises a first positive phase and a first negative phase, wherein the first positive phase comprises a first current and a first time and wherein the first negative phase comprises a second current and a second time, wherein the first current is greater than the second current and wherein the second time is greater than the first time, wherein the first time is between 0,5 μs and 130 μs, wherein there is a latency period, during which an applied current is zero, between the first positive phase and first negative phase, wherein the electroporation generator is further configured to receive a signal for identifying which pairs of the plurality of electrode elements have electrical characteristics indicative of contact with a target tissue when the target tissue is energized with an excitation signal, wherein the electroporation generator is configured to use an electroporation energization strategy to energize at least one of the pairs of the plurality of electrode elements identified as having contact with the target tissue with the asymmetric balanced waveform configured to irreversibly electroporate the target tissue; and wherein the electroporation generator is configured to determine whether neurostimulation will occur using the equation ∀ t ∈ 0 τ chron: ∫ 0 t E m dτ = ∫ 0 t 1 a m Φ m d τ < E threshold, wherein τ chron is the chronaxie time, a m is the thickness of the membrane, E threshold = E rheobase 1 + τ chron T, E rheobase is between 5,4 V/m and 20 V/m, T=1/f, f is the frequency of the applied electric field, Φ m is the applied voltage over the membrane, and E m is the applied electrical field. an electroporation generator, wherein the electroporation generator is configured to output an asymmetric balanced waveform to a medical device comprising an electrode assembly comprising a circular catheter having a plurality of electrode elements disposed on the circular catheter, wherein the asymmetric balanced waveform comprises a first positive phase and a first negative phase, wherein the first positive phase comprises a first current and a first time and wherein the first negative phase comprises a second current and a second time, wherein the first current is greater than the second current and wherein the second time is greater than the first time, wherein the first time is between 0,5 μs and 130 μs, wherein there is a latency period, during which an applied current is zero, between the first positive phase and first negative phase, wherein the electroporation generator is further configured to receive a signal for identifying which pairs of the plurality of electrode elements have electrical characteristics indicative of contact with a target tissue when the target tissue is energized with an excitation signal, wherein the electroporation generator is configured to use an electroporation energization strategy to energize at least one of the pairs of the plurality of electrode elements identified as having contact with the target tissue with the asymmetric balanced waveform configured to irreversibly electroporate the target tissue; and wherein the electroporation generator is configured to determine whether neurostimulation will occur using the equation ∀ t ∈ 0 τ chron: ∫ 0 t E m dτ = ∫ 0 t 1 a m Φ m d τ < E threshold, wherein τ chron is the chronaxie time, a m is the thickness of the membrane, E threshold = E rheobase 1 + τ chron T, E rheobase is between 5,4 V/m and 20 V/m, T=1/f, f is the frequency of the applied electric field, Φ m is the applied voltage over the membrane, and E m is the applied electrical field.