A tissue infiltration system comprising: at least a first and a second reaction chamber adapted to receive sequentially one and the same tissue sample, the first reaction chamber being adapted to receive a first dielectric fluid to be infiltrated into the tissue sample and the second reaction chamber being adapted to receive a second dielectric fluid to be infiltrated into a tissue sample, said first and second reaction chambers comprising a bottom and a circumferential wall; a holding element for sequentially holding a tissue transport basket configured to accommodate the tissue sample over a predetermined time period; a microwave system configured for irradiating microwave irradiation; and a transport mechanism adapted to create a relative motion between the first reaction chamber and the holding element and the second reaction chamber and the holding element such that the holding element holding the tissue transport basket is moved from inside the first reaction chamber to inside the second reaction chamber, wherein the system is a closed system and the first and second dielectrics are pre-filled into the first and second reaction chamber, respectively; characterized in that the circumferential wall comprises a window section that is transparent for microwave irradiation and the microwave system is configured to irradiate microwave irradiation sequentially through the window sections into the first and second reaction chambers; the holding element has a central axle of rotation and is adapted to be inserted into the reaction chamber so that the central axle of rotation rotates substantially around the axis of symmetry of the reaction chamber such that the tissue sample passes the window section at every round in a distance that is shorter than 3PD of the first and second dielectric fluid from the window section, wherein PD is the penetration depth of the microwaves into the dielectric fluid and defined as the depth where the initial microwave field intensity has been reduced to 1/e; and the system further comprises a drive mechanism connected to the central axle of rotation configured for rotating the holding element in the reaction chamber when infiltrating the tissue sample. at least a first and a second reaction chamber adapted to receive sequentially one and the same tissue sample, the first reaction chamber being adapted to receive a first dielectric fluid to be infiltrated into the tissue sample and the second reaction chamber being adapted to receive a second dielectric fluid to be infiltrated into a tissue sample, said first and second reaction chambers comprising a bottom and a circumferential wall; a holding element for sequentially holding a tissue transport basket configured to accommodate the tissue sample over a predetermined time period; a microwave system configured for irradiating microwave irradiation; and a transport mechanism adapted to create a relative motion between the first reaction chamber and the holding element and the second reaction chamber and the holding element such that the holding element holding the tissue transport basket is moved from inside the first reaction chamber to inside the second reaction chamber, wherein the system is a closed system and the first and second dielectrics are pre-filled into the first and second reaction chamber, respectively; characterized in that the circumferential wall comprises a window section that is transparent for microwave irradiation and the microwave system is configured to irradiate microwave irradiation sequentially through the window sections into the first and second reaction chambers; the holding element has a central axle of rotation and is adapted to be inserted into the reaction chamber so that the central axle of rotation rotates substantially around the axis of symmetry of the reaction chamber such that the tissue sample passes the window section at every round in a distance that is shorter than 3PD of the first and second dielectric fluid from the window section, wherein PD is the penetration depth of the microwaves into the dielectric fluid and defined as the depth where the initial microwave field intensity has been reduced to 1/e; and the system further comprises a drive mechanism connected to the central axle of rotation configured for rotating the holding element in the reaction chamber when infiltrating the tissue sample.