mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition for use in treating a subject having Hemophilia A, wherein the pharmaceutical composition comprises: (a) about 50 IU/ml to about 2500 IU/ml of a long-acting chimeric Factor VIII-Fc (rFVIIIFc) polypeptide; (b) about 13 mg/ml to about 20 mg/ml sucrose; (c) about 10 mg/ml to about 13 mg/ml sodium chloride (NaCl); (d) about 0.75 mg/ml to about 2.25 mg/ml L-histidine; (e) about 5mM to about 10mM calcium chloride; and (f) about 0.08 mg/ml to about 0.25 mg/ml polysorbate 20 or polysorbate 80, wherein the long-acting rFVIIIFc polypeptide comprises a first subunit and a second subunit, wherein the first subunit comprises an amino acid sequence at least 95% identical to amino acids 20 to 1684 of SEQ ID NO: 2, and wherein the second subunit comprises a first FcRn binding partner, wherein the first FcRn binding partner comprises an amino acid sequence at least 95% identical to amino acids 21 to 247 of SEQ ID NO: 4. (a) about 50 IU/ml to about 2500 IU/ml of a long-acting chimeric Factor VIII-Fc (rFVIIIFc) polypeptide; (b) about 13 mg/ml to about 20 mg/ml sucrose; (c) about 10 mg/ml to about 13 mg/ml sodium chloride (NaCl); (d) about 0.75 mg/ml to about 2.25 mg/ml L-histidine; (e) about 5mM to about 10mM calcium chloride; and (f) about 0.08 mg/ml to about 0.25 mg/ml polysorbate 20 or polysorbate 80, wherein the long-acting rFVIIIFc polypeptide comprises a first subunit and a second subunit, wherein the first subunit comprises an amino acid sequence at least 95% identical to amino acids 20 to 1684 of SEQ ID NO: 2, and wherein the second subunit comprises a first FcRn binding partner, wherein the first FcRn binding partner comprises an amino acid sequence at least 95% identical to amino acids 21 to 247 of SEQ ID NO: 4. wherein the long-acting rFVIIIFc polypeptide comprises a first subunit and a second subunit, wherein the first subunit comprises an amino acid sequence at least 95% identical to amino acids 20 to 1684 of SEQ ID NO: 2, and wherein the second subunit comprises a first FcRn binding partner, wherein the first FcRn binding partner comprises an amino acid sequence at least 95% identical to amino acids 21 to 247 of SEQ ID NO: 4.
A refrigerator comprising: a cabinet having a storage chamber; a main door rotatably coupled to the cabinet and configured to open and close the storage chamber, and including a frame assembly with an opening; a thermal insulator foamed in a foaming space that is defined by the frame assembly; and a sub door rotatably coupled to the main door and configured to open and close the opening, wherein the frame assembly includes: a first injection hole configured for the injection of foaming agent into the foaming space and positioned on a first surface of the frame assembly; a second injection hole configured for the injection of foaming agent into the foaming space and spaced apart from the first injection hole on the first surface of the frame assembly; a gasket installed on a second surface of the frame assembly, vent holes formed on the second surface of the frame assembly and spaced apart from the first and second injection holes (B4, B5), wherein the first surface is provided at an upper portion or a lower portion of the frame assembly, and the second surface is provided at a rear portion of the frame assembly. a cabinet having a storage chamber; a main door rotatably coupled to the cabinet and configured to open and close the storage chamber, and including a frame assembly with an opening; a thermal insulator foamed in a foaming space that is defined by the frame assembly; and a sub door rotatably coupled to the main door and configured to open and close the opening, wherein the frame assembly includes: a first injection hole configured for the injection of foaming agent into the foaming space and positioned on a first surface of the frame assembly; a second injection hole configured for the injection of foaming agent into the foaming space and spaced apart from the first injection hole on the first surface of the frame assembly; a gasket installed on a second surface of the frame assembly, vent holes formed on the second surface of the frame assembly and spaced apart from the first and second injection holes (B4, B5), wherein the first surface is provided at an upper portion or a lower portion of the frame assembly, and the second surface is provided at a rear portion of the frame assembly. a first injection hole configured for the injection of foaming agent into the foaming space and positioned on a first surface of the frame assembly; a second injection hole configured for the injection of foaming agent into the foaming space and spaced apart from the first injection hole on the first surface of the frame assembly; a gasket installed on a second surface of the frame assembly, vent holes formed on the second surface of the frame assembly and spaced apart from the first and second injection holes (B4, B5), wherein the first surface is provided at an upper portion or a lower portion of the frame assembly, and the second surface is provided at a rear portion of the frame assembly.
Mixer with a housing and with a mixing device drive arranged in the housing, wherein the mixing device drive for measuring a torque introduced into a medium to be mixed by said mixing device drive is mounted to pivot about a pivot axis within the housing, and is supported at least indirectly against at least one rotational direction (Pf. 1) of the mixing device drive, wherein the mixer has a measuring device for detecting a reaction force of this support.
Dryer or washer-dryer with a closed process air circuit comprising a drum, a condenser downstream the drum for dehumidifying warm air and a thermoelectric device having a cold side arranged in the process air circuit downstream the drum and arranged upstream the condenser, characterized in that the dryer or washer-dryer further comprises - a liquid/air heat exchanger arranged in the process air circuit downstream the condenser; - a liquid circuit; and wherein the thermoelectric device has warm side cooled by a liquid which is circulated in the liquid circuit from the warm side of the thermoelectric device to the liquid/air heat exchanger. - a liquid/air heat exchanger arranged in the process air circuit downstream the condenser; - a liquid circuit; and
Endless mat for a floor for livestock facilities, which floor is formed with a defined longitudinal direction, and in which direction the mat is arranged to be driven, wherein the mat comprises a liquid-impermeable support layer and a wear layer, which wear layer is applied on or integrated with said support layer and which support layer has the ability to be imposed an intermittent bending to essentially be able to connect against a cylindrical object having the diameter of Ø=2R o, and which mat is provided with slip-reducing means (502, 602, 603, 702, 802, 803, 902, 903), characterized in that said intermittent bending primarily is located to straight and parallel lines, grooves, or bands extending transversely to the driving direction of the mat in or on the wear layer, and that bending in these lines, grooves, or bands takes place with a radius r, wherein R o > r.
A method of detecting a disease associated with abnormal protein aggregation in a subject, comprising: contacting one or more non-plasma blood elements obtained from the subject with a conformationally-sensitive probe that binds to pathogenic protein aggregates, wherein the non-plasma blood elements are selected from red blood cells, microvesicles, leukocytes and platelets, generating a fluorescence emission spectra or absorption spectra of the probe bound to the pathogenic protein aggregates, wherein the emission spectra or the absorption spectra of the conformationally-sensitive probe changes when the probe is bound to the pathogenic protein aggregate, and comparing the fluorescence emission spectra or absorption spectra of the probe contacted with the non-plasma blood elements to one or more reference fluorescence emission spectra or absorption spectra, wherein the reference non-plasma blood elements are from a reference subject who has a disease associated with abnormal protein aggregation and correspondence between the fluorescence emission spectrum or absorption spectra and the one or more reference fluorescence emission spectra or absorption spectra is indicative that the subject has a disease associated with abnormal protein aggregation, wherein the disease associated with abnormal protein aggregation is Alzheimer's disease, mild cognitive impairment, cerebral amyloid angiopathy, brain trauma, traumatic brain injury, bovine spongiform encephalopathy or multiple sclerosis. contacting one or more non-plasma blood elements obtained from the subject with a conformationally-sensitive probe that binds to pathogenic protein aggregates, wherein the non-plasma blood elements are selected from red blood cells, microvesicles, leukocytes and platelets, generating a fluorescence emission spectra or absorption spectra of the probe bound to the pathogenic protein aggregates, wherein the emission spectra or the absorption spectra of the conformationally-sensitive probe changes when the probe is bound to the pathogenic protein aggregate, and comparing the fluorescence emission spectra or absorption spectra of the probe contacted with the non-plasma blood elements to one or more reference fluorescence emission spectra or absorption spectra, wherein the reference non-plasma blood elements are from a reference subject who has a disease associated with abnormal protein aggregation and correspondence between the fluorescence emission spectrum or absorption spectra and the one or more reference fluorescence emission spectra or absorption spectra is indicative that the subject has a disease associated with abnormal protein aggregation, wherein the disease associated with abnormal protein aggregation is Alzheimer's disease, mild cognitive impairment, cerebral amyloid angiopathy, brain trauma, traumatic brain injury, bovine spongiform encephalopathy or multiple sclerosis.
Process for moisturizing a human keratin material, in particular the skin, characterized in that it comprises the application to the surface of the said keratin material on contact with water of a composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium: a) at least one aqueous phase; and b) at least one oily phase comprising at least one apolar non-volatile hydrocarbon-based oil and at least one pasty apolar lipophilic hydrocarbon-based compound; and c) at least one hydrophilic gelling polysaccharide; and d) at least one mixture of emulsifying nonionic surfactants comprising (i) at least one fatty acid ester of polyol and (ii) at least one fatty acid ester of polyalkylene glycol. a) at least one aqueous phase; and b) at least one oily phase comprising at least one apolar non-volatile hydrocarbon-based oil and at least one pasty apolar lipophilic hydrocarbon-based compound; and c) at least one hydrophilic gelling polysaccharide; and d) at least one mixture of emulsifying nonionic surfactants comprising (i) at least one fatty acid ester of polyol and (ii) at least one fatty acid ester of polyalkylene glycol.
A recliner mechanism comprising: a first member (40, 340, 740) rotatably supported with respect to a second member (60, 360, 760); and at least one locking arm member (140, 160, 440, 460, 840, 860) movably located between the first and second members, the at least one locking arm member configured to lock the position of the first and second members with respect to one another in a locked position; wherein actuating a cam member (180, 480, 880) engages or disengages the at least one locking arm member to lock and unlock the first and second members; and wherein the first and second members have a plurality of stop members for engagement with each other to define the limits of travel of the recliner mechanism, characterized by further comprising at least one disc member (200, 500, 900, 902) located between the at least one locking arm member and the cam member when in the locked position, wherein, when moving into an unlocking position, the cam member contacts an abutment surface (174, 845) of the locking arm member so as to force the locking arm member to move and the disc member becomes free to move in a radially inward direction.
Roof joint for connecting a first carriage and a second carriage of a multi-unit vehicle, comprising a first main support extending to the first carriage and a second main support extending to the second carriage, wherein the first main support has a rotary joint, and wherein there is a rigid connection in the longitudinal direction between the first main support and the second main support, wherein the first main support and the second main support are connected to each other via a sliding guide, which is oriented in the transverse direction, wherein the roof joint is configured to build up a resetting force acting in the direction of a central position of the sliding guide, wherein an elastic resetting element is provided which is deformed by a movement of the sliding guide, characterized in that a tie rod is provided which extends through the elastic resetting element, wherein the elastic resetting element is connected to a transverse support of the first main support via the tie rod, and wherein the elastic resetting element is compressed by means of the tie rod.
A Global Positioning System signal optimizing garment (100, 200, 300, 400, 502), the garment (100, 200, 300, 400, 502) comprising: a shirt (105, 205, 305, 505) that extends around at least a portion of a wearer's torso in an as worn position, the shirt (105, 205, 305, 505) having a front (115, 306, 506) and a back (117, 220, 307, 420, 507); and a three-dimensional pocket (110, 210, 310, 410, 510) attached to the back (117, 220, 307, 420, 507) of the shirt (105, 205, 305, 505) at least 2.5cm (one inch) from a neckline (125, 215, 315, 415, 515) of the back (117, 220, 307, 420, 507) of the shirt (105, 205, 305, 505), the pocket (110, 210, 310, 410, 510) having a size to hold a GPS device (225, 325, 425), characterised in that the garment (100, 200, 300, 400, 502) further comprises four heart rate monitor tabs (135, 700) attached to the inside of the garment (100, 200, 300, 400, 502) below sleeves thereof, wherein two heart rate monitor tabs (135, 700) are below each sleeve to receive and retain heart rate monitor chest straps and enable a heart rate monitor device to be attached to the chest of the wearer when the garment (100, 200, 300, 400, 502) is in an as worn position. a shirt (105, 205, 305, 505) that extends around at least a portion of a wearer's torso in an as worn position, the shirt (105, 205, 305, 505) having a front (115, 306, 506) and a back (117, 220, 307, 420, 507); and a three-dimensional pocket (110, 210, 310, 410, 510) attached to the back (117, 220, 307, 420, 507) of the shirt (105, 205, 305, 505) at least 2.5cm (one inch) from a neckline (125, 215, 315, 415, 515) of the back (117, 220, 307, 420, 507) of the shirt (105, 205, 305, 505), the pocket (110, 210, 310, 410, 510) having a size to hold a GPS device (225, 325, 425), characterised in that the garment (100, 200, 300, 400, 502) further comprises four heart rate monitor tabs (135, 700) attached to the inside of the garment (100, 200, 300, 400, 502) below sleeves thereof, wherein two heart rate monitor tabs (135, 700) are below each sleeve to receive and retain heart rate monitor chest straps and enable a heart rate monitor device to be attached to the chest of the wearer when the garment (100, 200, 300, 400, 502) is in an as worn position.
Method for inserting a wire (7a, 7b) into a longitudinal groove (2a, 2b) of a semiconductor chip with a view to the assembly thereof, the groove containing a pad (6a, 6b) made of a bonding material having a predetermined melting point, the pad (6a, 6b) occupying a sufficient portion of the groove (2a, 2b) so as to not allow the wire to be fully accommodated therein, the method comprising: - in an installation step, arranging a longitudinal portion of the wire (7a, 7b) along the groove (2a, 2b), in forced abutment against the pad (6a, 6b); - in an insertion step, exposing a region containing at least part of the pad (6a, 6b) to a treatment temperature above the melting point of the bonding material and for a period of time which is sufficient to melt at least part of the pad (6a, 6b), and thus cause the wire (7a, 7b) to be inserted into the groove (2a, 2b). - in an installation step, arranging a longitudinal portion of the wire (7a, 7b) along the groove (2a, 2b), in forced abutment against the pad (6a, 6b); - in an insertion step, exposing a region containing at least part of the pad (6a, 6b) to a treatment temperature above the melting point of the bonding material and for a period of time which is sufficient to melt at least part of the pad (6a, 6b), and thus cause the wire (7a, 7b) to be inserted into the groove (2a, 2b).
A device for determining a cyclic shift diversity, CSD, value for a wireless transmission, the device comprising storage and processing circuitry configured to: identify a first high efficiency, HE, frame received from an access point, characterized in that the first HE frame comprises an indication of the CSD value of a second high efficiency, HE, frame, the indication provided in a high efficiency signal-B, HE-SIG-B, field of the first HE frame; determine the CSD value based on the indication; and cause to send the second HE frame in a spatial stream using the CSD value. identify a first high efficiency, HE, frame received from an access point, characterized in that the first HE frame comprises an indication of the CSD value of a second high efficiency, HE, frame, the indication provided in a high efficiency signal-B, HE-SIG-B, field of the first HE frame; determine the CSD value based on the indication; and cause to send the second HE frame in a spatial stream using the CSD value.
A steering apparatus that is capable of adjusting a position of a steering wheel by moving a column that holds a shaft of the steering wheel with respect to a vehicle body, the steering apparatus comprising: a pivot lever for clamping and unclamping the column with respect to the vehicle body; a cam (120, 121) that clamps and unclamps the column by changing a turn of the pivot lever into an axial movement of said turn; a sleeve that holds the cam (120, 121) and slides against the cam (120, 121) when the pivot lever is turned; and a rattle mitigating member, characterized in that the rattle mitigating member is configured to increase at least any one of friction forces from among a friction force generated between the sleeve and a sliding surface of the cam (120, 121) or a friction force generated between the sleeve and the pivot lever. a pivot lever for clamping and unclamping the column with respect to the vehicle body; a cam (120, 121) that clamps and unclamps the column by changing a turn of the pivot lever into an axial movement of said turn; a sleeve that holds the cam (120, 121) and slides against the cam (120, 121) when the pivot lever is turned; and a rattle mitigating member, characterized in that the rattle mitigating member is configured to increase at least any one of friction forces from among a friction force generated between the sleeve and a sliding surface of the cam (120, 121) or a friction force generated between the sleeve and the pivot lever.
A composition comprising 5 - 50 wt% of calcium silicate hydrate, 10 - 60 wt% of at least one water-soluble, acid group-containing polymer comprising polyether groups, 5 - 40 wt% of at least one polyalkylene glycol ether of the formula R α -(C β H 2β O) ω -H where R α is hydrogen or an aliphatic hydrocarbon radical having 1 to 20 C atoms, a cycloaliphatic hydrocarbon radical having 5 to 8 C atoms, or an optionally substituted aryl radical having 6 to 14 C atoms, the aryl radical comprising no acid groups, and β independently at each occurrence and in a manner identical or different for each (C β H 2β O) unit is 2, 3, 4 or 5, and ω is 3 to 200. R α is hydrogen or an aliphatic hydrocarbon radical having 1 to 20 C atoms, a cycloaliphatic hydrocarbon radical having 5 to 8 C atoms, or an optionally substituted aryl radical having 6 to 14 C atoms, the aryl radical comprising no acid groups, and β independently at each occurrence and in a manner identical or different for each (C β H 2β O) unit is 2, 3, 4 or 5, and ω is 3 to 200.
A screw joint arrangement for connecting flared pipe ends (8, 17) of two pipes (6, 18), comprising two pipes (6, 18) with flared pipe ends (8, 17), a screw, a screw nut and a spacer element, wherein the screw nut features a front opening and a preferably cylindrical receptacle space extends from said front opening in the direction of a rear opening of the screw nut, wherein a surface of the screw nut on the side of the receptacle space features a thread section, wherein said thread section is realized in the form of an internal thread and, starting from the front opening, sectionally extends into the receptacle space in the direction of the rear opening, wherein the rear opening is arranged in a rear end wall of the screw nut and said rear end wall features a connection face on the side of the receptacle space, wherein the spacer element and a first pipe end with a first flare can be accommodated in the screw nut in a preassembled state, wherein a thread profile of the internal thread extends into the receptacle space in such a way that the spacer element is in the preassembled state captively held in the receptacle space between the first flare and the internal thread with predefined play, wherein a second pipe end with a second flare can be held in the screw, wherein an assembled state can be procuced by screwing the screw into the screw nut, wherein the screw can in the assembled state act upon the second flare with a motive force in such a way that the second flare is pressed against a sealing face (second sealing face) of the spacer element and the spacer element is pressed against the first flare with an additional sealing face (first sealing face) such that a rear contact face of the first flare is in the assembled state pressed against the connection face of the screw nut, and wherein the spacer element features an external thread that is realized complementary to the internal thread of the screw nut, characterized in that the spacer element is held in the receptacle space in such a way that the spacer element is only movable in the axial direction or the longitudinal direction of the receptacle space, respectively.
Apparatus for sensing a movement of a moving object (10,11) relative to a fluid (12, 13), e.g. for sensing relative movements of a surf board in water, comprising a housing mounted inside the object (10, 11) in fixed arrangement to a surface of the object, the housing comprising a cover element, which is mounted in flush arrangement to the surface, the housing receiving a spring member having a plurality of blades (25a, 25b, 25c, 25d), wherein each blade has an outer end which is fixed to the housing, and an inner end which is connecting to a center portion of the spring, the plurality of blades defining a plane, wherein a plurality of strain gauges (26a, 26b, 26c, 26d) is positioned on the blades, and wherein a rigid pin is mounted, the rigid pin being elongate and having an inner end and a free end, the rigid pin being mounted with its inner end on the center portion of the spring member, said pin is extending in a direction of a normal vector of the plane, through a bore in the cover element, and said pin protruding outward from the bore, and said free end of the pin being configured to dip into the fluid.