mhurhangee/ep-ind-claims huggingface dataset:
A catheter comprising: a shaft having a proximal end and a distal end, the distal end terminating in a tip; a drainage opening located at the distal end of the shaft and on a side of the shaft, the drainage opening communicating with a drainage lumen of the shaft; a balloon located at the distal end of the shaft, the balloon comprising a first region secured to the shaft, a second region secured to the shaft and an elastic-walled and/or flexible-walled conduit extending between the first region and the second region, the conduit extending over the tip; wherein at least part of the balloon is in the form of an elongate tube, the elongate tube being folded over the tip. a shaft having a proximal end and a distal end, the distal end terminating in a tip; a drainage opening located at the distal end of the shaft and on a side of the shaft, the drainage opening communicating with a drainage lumen of the shaft; a balloon located at the distal end of the shaft, the balloon comprising a first region secured to the shaft, a second region secured to the shaft and an elastic-walled and/or flexible-walled conduit extending between the first region and the second region, the conduit extending over the tip; wherein at least part of the balloon is in the form of an elongate tube, the elongate tube being folded over the tip.
A combination comprising doxycycline and an inhibitor of glycolytic metabolism for use in a method of treating doxycycline-resistant cancer stem cells.
A motorized tensioning system for an article of footwear, comprising: a motor; a lace; a spool comprising a receiving portion for receiving the lace, wherein the receiving portion comprises a first lace winding region and a second lace winding region separated by a dividing portion; a gear reduction assembly connecting the spool with the motor; wherein the lace is provided in sections and includes a first tensile member portion, a second tensile member portion and a third tensile member portion; wherein the second tensile member portion is releasably attached to the first tensile member portion, and wherein the third tensile member portion is releasably attached to the first tensile member portion; wherein the dividing portion includes a lace receiving channel extending through the dividing portion; wherein the lace receiving channel is configured to retain the first tensile member portion of the lace on the spool; and wherein the spool is configured to tighten the motorized tensioning system by winding the two ends of lace around the first lace winding region and the second lace winding region. a motor; a lace; a spool comprising a receiving portion for receiving the lace, wherein the receiving portion comprises a first lace winding region and a second lace winding region separated by a dividing portion; a gear reduction assembly connecting the spool with the motor; wherein the lace is provided in sections and includes a first tensile member portion, a second tensile member portion and a third tensile member portion; wherein the second tensile member portion is releasably attached to the first tensile member portion, and wherein the third tensile member portion is releasably attached to the first tensile member portion; wherein the dividing portion includes a lace receiving channel extending through the dividing portion; wherein the lace receiving channel is configured to retain the first tensile member portion of the lace on the spool; and wherein the spool is configured to tighten the motorized tensioning system by winding the two ends of lace around the first lace winding region and the second lace winding region.
An electrosurgical instrument for treating biological tissue, the instrument comprising: a coaxial transmission line (303, 304) for conveying microwave electromagnetic energy, the coaxial transmission line comprising an inner conductor, outer conductor, and a dielectric material separating the inner conductor and the outer conductor; a radiating tip mounted at a distal end of the coaxial transmission line to receive and radiate the microwave EM energy from the coaxial transmission line into a treatment zone around the radiating tip, the radiating tip comprising a distal conductive section of the inner conductor that extends beyond a distal end of the outer conductor; a fluid feed for conveying a tissue-freezing fluid to the treatment zone, wherein the inner conductor of the coaxial transmission line is hollow to provide a passageway for the fluid feed; and a thermal transfer portion connected to receive the tissue-freezing fluid from the fluid feed at a distal end of the coaxial transmission line, wherein the thermal transfer portion is arranged to provide thermal communication between the tissue-freezing fluid and biological tissue in the treatment zone to freeze the biological tissue in the treatment zone, wherein the fluid feed comprises a delivery conduit for conveying the tissue-freezing fluid to the thermal transfer portion, wherein the thermal transfer portion comprises an outlet configured to deliver the tissue-freezing fluid into the treatment zone, and wherein the instrument further comprises a decompression tube configured to convey gas away from the treatment zone. a coaxial transmission line (303, 304) for conveying microwave electromagnetic energy, the coaxial transmission line comprising an inner conductor, outer conductor, and a dielectric material separating the inner conductor and the outer conductor; a radiating tip mounted at a distal end of the coaxial transmission line to receive and radiate the microwave EM energy from the coaxial transmission line into a treatment zone around the radiating tip, the radiating tip comprising a distal conductive section of the inner conductor that extends beyond a distal end of the outer conductor; a fluid feed for conveying a tissue-freezing fluid to the treatment zone, wherein the inner conductor of the coaxial transmission line is hollow to provide a passageway for the fluid feed; and a thermal transfer portion connected to receive the tissue-freezing fluid from the fluid feed at a distal end of the coaxial transmission line, wherein the thermal transfer portion is arranged to provide thermal communication between the tissue-freezing fluid and biological tissue in the treatment zone to freeze the biological tissue in the treatment zone, wherein the fluid feed comprises a delivery conduit for conveying the tissue-freezing fluid to the thermal transfer portion, wherein the thermal transfer portion comprises an outlet configured to deliver the tissue-freezing fluid into the treatment zone, and wherein the instrument further comprises a decompression tube configured to convey gas away from the treatment zone.
A composition comprising a PD-1 antagonist or a TLR9 agonist for use in treating cancer in an individual comprising administering to the individual a combination therapy which comprises a PD-1 antagonist and a TLR9 agonist, wherein the TLR9 agonist is a CpG-C type oligonucleotide, wherein: (a) the PD-1 antagonist is a monoclonal antibody, or antigen binding fragment thereof, which comprises: (a) light chain CDRs of SEQ ID NOs:1, 2 and 3 and heavy chain CDRs of SEQ ID NOs:4, 5 and 6; or (b) light chain CDRs of SEQ ID NOs:7, 8 and 9 and heavy chain CDRs of SEQ ID NOs:10, 11 and 12; and (b) the TLR9 agonist is a CpG-C type oligonucleotide, wherein the CpG-C type oligonucleotide comprises 5'-TCG N q TTCGA ACG TTC GAA CGT TCG AAT-3', wherein N are nucleosides and q=4. (a) the PD-1 antagonist is a monoclonal antibody, or antigen binding fragment thereof, which comprises: (a) light chain CDRs of SEQ ID NOs:1, 2 and 3 and heavy chain CDRs of SEQ ID NOs:4, 5 and 6; or (b) light chain CDRs of SEQ ID NOs:7, 8 and 9 and heavy chain CDRs of SEQ ID NOs:10, 11 and 12; and (b) the TLR9 agonist is a CpG-C type oligonucleotide, wherein the CpG-C type oligonucleotide comprises 5'-TCG N q TTCGA ACG TTC GAA CGT TCG AAT-3', wherein N are nucleosides and q=4.
A medical system comprising an instrument, a position acquisition apparatus (12, 14) for the instrument, a data processing and image generating apparatus and an image display and control unit, of which the position acquisition apparatus (12, 14) is embodied to acquire a position of the instrument in relation to a reference coordinate system and of which the data processing and image generating apparatus is embodied to generate an image of a body part from currently recorded or stored data representing a body part, which image reproduces a view of the body part together with a representation of the position of the instrument in such a way that an observer can gather the position of the instrument in the body part from the image of the body part, wherein the image display and control unit is wirelessly connected to the data processing and image generating apparatus, and comprises a display and input unit with a closed surface, on which control elements and a respective view of the body part are displayed during operation, together with a representation of the position of the instrument, wherein the image display and control unit is furthermore embodied to accept user inputs via displayed control elements and to transmit control signals to those of the data processing and image generating apparatus as a function of the respectively accepted user inputs, characterized in that basic settings concerning the representation are stored for different image display and control units on the data processing and image generating apparatus.
A structural component for a motor vehicle, comprising first and second profiled sheet metal parts (101, 102) joined together by welding spots, which sheet metal parts (101, 102) have opposing free ends (103, 104) arranged to be mating to form an overlapping portion over a predetermined distance, wherein a cross-section of the component through the overlapping portion has a hat shape comprising - first and second edge portions (111, 112; 121, 122) extending in the longitudinal direction of the component; - first and second side portions (113, 114; 123, 124) arranged to join a respective edge portion; and - a central portion (115; 125) arranged to join the side portions (113, 114; 123, 124); characterized in that the free end of the central portion (115; 125) of each sheet metal part comprises at least two tabs (116, 117; 126, 127) separated by a recess, and that the tabs (116, 117; 126, 127) of the first and second sheet metal parts (101, 102) are joined to a part of an adjacent central portion (115; 125) by welding. - first and second edge portions (111, 112; 121, 122) extending in the longitudinal direction of the component; - first and second side portions (113, 114; 123, 124) arranged to join a respective edge portion; and - a central portion (115; 125) arranged to join the side portions (113, 114; 123, 124); characterized in that
A super-absorbent liquid-controlled bolster (31, 131), comprising: a breathable, fluid-restricted dry layer (38, 138) for placement against a wound and having a first surface (40, 140) and a second surface (42, 142) the breathable, fluid restricted dry layer (38, 138) being adapted to allow a gas to permeate and adapted to allow fluid flow in only one direction through the breathable, fluid restricted dry layer (38, 138) from the second surface (42, 142) to the first surface (40, 140) and restrict fluid flow in the other direction; a super-absorbent layer (32, 132) having a first surface (34, 134) and second surface (36, 136), the second surface (36, 136) of the super-absorbent layer (32, 132) disposed adjacent to the first surface (40, 140) of the breathable dry layer (38, 138); and a non-breathable layer (44, 144) having a first surface (46, 146) and a second surface (48, 148), the second surface (48, 148) of the non-breathable layer (44, 144) disposed adjacent to the first surface (34, 134) of the super-absorbent layer (32, 132); wherein the super-absorbent layer (32, 132) is adapted to become more rigid with the addition of fluid. a breathable, fluid-restricted dry layer (38, 138) for placement against a wound and having a first surface (40, 140) and a second surface (42, 142) the breathable, fluid restricted dry layer (38, 138) being adapted to allow a gas to permeate and adapted to allow fluid flow in only one direction through the breathable, fluid restricted dry layer (38, 138) from the second surface (42, 142) to the first surface (40, 140) and restrict fluid flow in the other direction; a super-absorbent layer (32, 132) having a first surface (34, 134) and second surface (36, 136), the second surface (36, 136) of the super-absorbent layer (32, 132) disposed adjacent to the first surface (40, 140) of the breathable dry layer (38, 138); and a non-breathable layer (44, 144) having a first surface (46, 146) and a second surface (48, 148), the second surface (48, 148) of the non-breathable layer (44, 144) disposed adjacent to the first surface (34, 134) of the super-absorbent layer (32, 132); wherein the super-absorbent layer (32, 132) is adapted to become more rigid with the addition of fluid.
A system for recognizing an order of signals, including in a cell of an analog-to-digital converter, used to determine a value of a bit having index x of an n-bit output digital word, a main MUTEX circuit provided with a set input connected to an input of a source signal and a reset input connected to an input of a reference signal and a first output connected to a first control input of a path configuration circuit and a second output connected to a second control input of the path configuration circuit, and furthermore the input of the source signal is connected to an input of a first delay circuit, whose output is connected to an input of a source path of the path configuration circuit, whereas the input of the reference signal is connected to an input of a second delay circuit, whose output is connected to an input of a reference path of the path configuration circuit, wherein propagation time of the first delay circuit is equal to propagation time of the second delay circuit and longer than nominal propagation delay of the main MUTEX circuit, characterized in that the input of the source signal (Sc x) is connected to a first input of a first gate (B1 x), whose second input is connected to the input of the reference signal (Rf x), whereas an output of the first gate (B1 x) is connected to an input of an additional delay circuit (T Dx), whose output is connected to a reset input of an additional MUTEX circuit (MA x), wherein propagation time (to) of the additional delay circuit (T Dx) is shorter than the propagation time (t M) of the first delay circuit (T M1x) and at the same time longer than the nominal propagation delay (t N) of the main MUTEX circuit (MM x), and the first output of the main MUTEX circuit (MM x) is connected to a data input (D x) of an output module and to a first input of a second gate (B2 x), whose second input is connected to the second output of the main MUTEX circuit (MM x), whereas an output of the second gate (B2 x) is connected to a set input of the additional MUTEX circuit (MA x), whose second output is connected to a priority input (Prt x) of the output module equipped with outputs of bits (b n-1,..., b 0) of the n-bit output digital word.
An ice protection assembly comprising: an aircraft component having a surface; a pressure sensitive adhesive on the surface of the aircraft component, wherein the pressure sensitive adhesive is loaded with nanoparticles, and characterised in that the pressure sensitive adhesive has a dynamic storage modulus (G') at 0.01 radians/second of less than 300 kPa, a dynamic storage modulus (G') greater than 30 kPa between -40 °C and 71 °C and a dynamic loss modulus (G") greater than 32 kPa between -40 °C and 71 °C and the pressure sensitive adhesive is selected from the group consisting of acrylates, silicones, nitriles, and styrenes and the nanoparticles have diameters ranging from 50 μm to 5 nm and comprise between 5% to 25% by volume of the pressure sensitive adhesive; and a heater attached to the aircraft component by the pressure sensitive adhesive. an aircraft component having a surface; a pressure sensitive adhesive on the surface of the aircraft component, wherein the pressure sensitive adhesive is loaded with nanoparticles, and characterised in that the pressure sensitive adhesive has a dynamic storage modulus (G') at 0.01 radians/second of less than 300 kPa, a dynamic storage modulus (G') greater than 30 kPa between -40 °C and 71 °C and a dynamic loss modulus (G") greater than 32 kPa between -40 °C and 71 °C and the pressure sensitive adhesive is selected from the group consisting of acrylates, silicones, nitriles, and styrenes and the nanoparticles have diameters ranging from 50 μm to 5 nm and comprise between 5% to 25% by volume of the pressure sensitive adhesive; and a heater attached to the aircraft component by the pressure sensitive adhesive.
Product surface having an optoelectronically readable code, which is formed by an arrangement of flat cells (6, 7) of different cell types, - the cells (6, 7) being an integral component of the product surface, - the cells (6, 7) of each cell type each having a surface profile, - the surface profile of at least one cell type having at least one elevation and/or depression relative to the product surface, and - the surface profile of a first cell type being formed relative to the surface profile of a second cell type such that the reflective properties of the surface profile of the first cell type differ from the reflective properties of the surface profile of the second cell type, characterized in that - the surface profiles of the cell types of a code differ in their surface roughness, and in that the ratio of the surface roughness of the surface profile of a first cell type relative to the surface roughness of the surface profile of a second cell type is at least 20. - the cells (6, 7) being an integral component of the product surface, - the cells (6, 7) of each cell type each having a surface profile, - the surface profile of at least one cell type having at least one elevation and/or depression relative to the product surface, and - the surface profile of a first cell type being formed relative to the surface profile of a second cell type such that the reflective properties of the surface profile of the first cell type differ from the reflective properties of the surface profile of the second cell type, - the surface profiles of the cell types of a code differ in their surface roughness, and in that the ratio of the surface roughness of the surface profile of a first cell type relative to the surface roughness of the surface profile of a second cell type is at least 20.
A stimulator device, comprising: a plurality of electrode nodes, each electrode node configured to be coupled to one of a plurality of electrodes configured to contact a patient's tissue; stimulation circuitry configured to execute a stimulation program to provide a stimulation current to at least two of the electrode nodes, wherein the stimulation program comprises a plurality of sub-programs configured to be executed by the stimulation circuitry; and controller circuitry, characterised in that the controller circuitry is configured to periodically store information that indicates where the stimulation circuitry is in its execution of the plurality of sub-programs, and if the stimulator device experiences an interruption that prevents the stimulation circuitry from continuing execution of the plurality of sub-programs, use the stored information to continue execution of the plurality of sub-programs at a point corresponding to the interruption. a plurality of electrode nodes, each electrode node configured to be coupled to one of a plurality of electrodes configured to contact a patient's tissue; stimulation circuitry configured to execute a stimulation program to provide a stimulation current to at least two of the electrode nodes, wherein the stimulation program comprises a plurality of sub-programs configured to be executed by the stimulation circuitry; and controller circuitry, characterised in that the controller circuitry is configured to periodically store information that indicates where the stimulation circuitry is in its execution of the plurality of sub-programs, and if the stimulator device experiences an interruption that prevents the stimulation circuitry from continuing execution of the plurality of sub-programs, use the stored information to continue execution of the plurality of sub-programs at a point corresponding to the interruption. periodically store information that indicates where the stimulation circuitry is in its execution of the plurality of sub-programs, and if the stimulator device experiences an interruption that prevents the stimulation circuitry from continuing execution of the plurality of sub-programs, use the stored information to continue execution of the plurality of sub-programs at a point corresponding to the interruption.
An apparatus (10; 100) for the continuous hot dip coating of a metal strip, including: - a vessel intended to contain a liquid metal bath, - a bottom roller arranged in the vessel and intended to be immersed in the liquid metal bath, - a displacement casing for the metal strip whose lower end is intended to be immersed in the liquid metal bath to determine, with the surface of said bath and the inside of said casing, a liquid metal seal, the casing including an upper portion and a lower portion, said lower portion bearing a pouring box delimiting at least two liquid metal pouring compartments (25, 29), each pouring compartment (25, 29) being inwardly delimited by an inner wall (20, 26), the inner wall (20, 26) including an upper rim (21, 27), the upper rim (21; 27) of each inner wall (20, 26) being intended to be arranged below the liquid seal surface to produce a flow from said surface into each of said pouring compartments (25; 29), the apparatus being characterised in that the casing provided with the pouring box is rotatable relative to the metal strip around a first rotation axis; and in that the pouring box is rotatable relative to the upper portion of the casing around a second rotation axis, the second rotation axis being substantially parallel to the first rotation axis, the articulation allowing the rotation of the pouring box relative to the upper portion of the casing being a pivot link. - a vessel intended to contain a liquid metal bath, - a bottom roller arranged in the vessel and intended to be immersed in the liquid metal bath, - a displacement casing for the metal strip whose lower end is intended to be immersed in the liquid metal bath to determine, with the surface of said bath and the inside of said casing, a liquid metal seal, the casing including an upper portion and a lower portion, said lower portion bearing a pouring box delimiting at least two liquid metal pouring compartments (25, 29), each pouring compartment (25, 29) being inwardly delimited by an inner wall (20, 26), the inner wall (20, 26) including an upper rim (21, 27), the upper rim (21; 27) of each inner wall (20, 26) being intended to be arranged below the liquid seal surface to produce a flow from said surface into each of said pouring compartments (25; 29), the apparatus being characterised in that the casing provided with the pouring box is rotatable relative to the metal strip around a first rotation axis; and in that the pouring box is rotatable relative to the upper portion of the casing around a second rotation axis, the second rotation axis being substantially parallel to the first rotation axis, the articulation allowing the rotation of the pouring box relative to the upper portion of the casing being a pivot link.