A medical injection device for setting and injecting set doses from a held drug cartridge, comprising: - a housing (110, 120, 130, 140) defining proximal and distal ends, - a dose setting arrangement including a dose setting device (350,400) that is moved in a first direction away from a predetermined stop in accordance with the size of a set dose and that moves back to the predetermined stop during injection of the set dose, the predetermined stop being configured for being fixedly arranged relative to the housing (110, 120, 130, 140), - an injection activator adapted to be activated to inject the set dose, - a piston rod adapted to translate relative to the housing (110, 120, 130, 140) in a distal direction in order to expel a set dose, and - a rotatable driver (500, 560, 600, 700) coupled to the piston rod and including a stored energy source configured to drive rotation of the driver (500, 560, 600, 700) when the injection activator is activated to cause the piston rod to translate relative to the housing (110, 120, 130, 140), Wherein: - the dose setting device (350, 400) defines a dose control member configured for rotation around a first axis, - a first clutch arrangement (C1, 352, 502) is arranged between the dose control member and the driver (500, 560, 600, 700), wherein the first clutch arrangement (C1, 352, 502) is disengaged during dose setting so that the dose control member rotates independently of the driver (500, 560, 600, 700), and wherein the first clutch arrangement (C1, 352, 502) engages upon activation of the injection activator to enable the driver (500, 560, 600, 700) to rotate the dose control member while causing the dose setting device (350,400) to move back towards the predetermined stop, and - a second clutch arrangement (C2, 122, 372) arranged between the driver (500, 560, 600, 700) and the housing (110, 120, 130, 140), wherein the second clutch arrangement (C2, 122, 372) is engaged during dose setting so that the driver (500, 560, 600, 700) is prevented from rotating during dose setting, and wherein the second clutch arrangement (C2, 122, 372) disengages upon activation of the injection activator to enable the driver (500, 560, 600, 700) to rotate relative to the housing (110, 120, 130, 140). - a housing (110, 120, 130, 140) defining proximal and distal ends, - a dose setting arrangement including a dose setting device (350,400) that is moved in a first direction away from a predetermined stop in accordance with the size of a set dose and that moves back to the predetermined stop during injection of the set dose, the predetermined stop being configured for being fixedly arranged relative to the housing (110, 120, 130, 140), - an injection activator adapted to be activated to inject the set dose, - a piston rod adapted to translate relative to the housing (110, 120, 130, 140) in a distal direction in order to expel a set dose, and - a rotatable driver (500, 560, 600, 700) coupled to the piston rod and including a stored energy source configured to drive rotation of the driver (500, 560, 600, 700) when the injection activator is activated to cause the piston rod to translate relative to the housing (110, 120, 130, 140), - the dose setting device (350, 400) defines a dose control member configured for rotation around a first axis, - a first clutch arrangement (C1, 352, 502) is arranged between the dose control member and the driver (500, 560, 600, 700), wherein the first clutch arrangement (C1, 352, 502) is disengaged during dose setting so that the dose control member rotates independently of the driver (500, 560, 600, 700), and wherein the first clutch arrangement (C1, 352, 502) engages upon activation of the injection activator to enable the driver (500, 560, 600, 700) to rotate the dose control member while causing the dose setting device (350,400) to move back towards the predetermined stop, and - a second clutch arrangement (C2, 122, 372) arranged between the driver (500, 560, 600, 700) and the housing (110, 120, 130, 140), wherein the second clutch arrangement (C2, 122, 372) is engaged during dose setting so that the driver (500, 560, 600, 700) is prevented from rotating during dose setting, and wherein the second clutch arrangement (C2, 122, 372) disengages upon activation of the injection activator to enable the driver (500, 560, 600, 700) to rotate relative to the housing (110, 120, 130, 140).