A compound of Formula: or a stereoisomer, a geometric isomer, a tautomer, an N- oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein: Q is -N(R c)C(=O)R d; W is CR 7 or N; each of X, Y and Z is independently H, D, (C 1 -C 6)alky), (C 3 -C 8)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 8)cycloalkyl, (C 3 -C 7)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 7)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl or -(C 1 -C 4)alkylene-(5-10 membered heteroaryl), wherein each of the (C 1 -C 6)alkyl, (C 3 -C 8)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 8)cycloalkyl, (C 3 -C 7)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 7)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl, - (C 1 -C 4)alkylene-(C 6 -C 10)aryl and -(C 1 -C 4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from D, F, Cl, Br, CN, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, OR a, NR a R b, -(C 1 -C 4)alkylene-OR a and -(C 1 -C 4)alkylene-NR a R b; each of R 1, R 2, R 3, R 4, R 5, R 6 and R 7 is independently H, D, F, Cl, Br, CN, N 3, OR a, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 2 -C 6)alkenyl or (C 2 -C 6)alkynyl; each of R a, R b and R c is independently H, (C 1 -C 6)aliphatic, (C 1 -C 6)haloalkyl, (C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl or -(C 1 -C 4)alkylene-(5-10 membered heteroaryl), with the proviso wherein R a and R b are bonded to the same nitrogen atom, R a and R b, together with the nitrogen atom they are attached to, optionally form a substituted or unsubstituted 3-8 membered heterocyclic ring, wherein each of the (C 1 -C 6)aliphatic, (C 1 -C 6)haloalkyl, (C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl, -(C 1 -C 4)alkylene-(5-10 membered heteroaryl) and 3-8 membered heterocyclic ring is optionally substituted with 1, 2, 3 or 4 substitutents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy and (C 1 -C 6)alkylamino; and R d is (C 1 -C 6)alkyl, wherein the (C 1 -C 6)alkyl is optionally substituted with 1, 2, 3 or 4 substitutents independently selected from D, F, Cl, Br, CN, OR a, NR a R b,-(C 1 -C 4)alkylene-OR a and - (C 1 -C 4)alkylene-NR a R b. Q is -N(R c)C(=O)R d; W is CR 7 or N; each of X, Y and Z is independently H, D, (C 1 -C 6)alky), (C 3 -C 8)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 8)cycloalkyl, (C 3 -C 7)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 7)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl or -(C 1 -C 4)alkylene-(5-10 membered heteroaryl), wherein each of the (C 1 -C 6)alkyl, (C 3 -C 8)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 8)cycloalkyl, (C 3 -C 7)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 7)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl, - (C 1 -C 4)alkylene-(C 6 -C 10)aryl and -(C 1 -C 4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from D, F, Cl, Br, CN, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, OR a, NR a R b, -(C 1 -C 4)alkylene-OR a and -(C 1 -C 4)alkylene-NR a R b; each of R 1, R 2, R 3, R 4, R 5, R 6 and R 7 is independently H, D, F, Cl, Br, CN, N 3, OR a, (C 1 -C 6)alkyl, (C 1 -C 6)haloalkyl, (C 2 -C 6)alkenyl or (C 2 -C 6)alkynyl; each of R a, R b and R c is independently H, (C 1 -C 6)aliphatic, (C 1 -C 6)haloalkyl, (C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl or -(C 1 -C 4)alkylene-(5-10 membered heteroaryl), with the proviso wherein R a and R b are bonded to the same nitrogen atom, R a and R b, together with the nitrogen atom they are attached to, optionally form a substituted or unsubstituted 3-8 membered heterocyclic ring, wherein each of the (C 1 -C 6)aliphatic, (C 1 -C 6)haloalkyl, (C 3 -C 6)cycloalkyl, -(C 1 -C 4)alkylene-(C 3 -C 6)cycloalkyl, (C 3 -C 6)heterocyclyl, -(C 1 -C 4)alkylene-(C 3 -C 6)heterocyclyl, (C 6 -C 10)aryl, 5-10 membered heteroaryl, -(C 1 -C 4)alkylene-(C 6 -C 10)aryl, -(C 1 -C 4)alkylene-(5-10 membered heteroaryl) and 3-8 membered heterocyclic ring is optionally substituted with 1, 2, 3 or 4 substitutents independently selected from D, F, Cl, CN, N 3, OH, NH 2, (C 1 -C 6)haloalkyl, (C 1 -C 6)alkoxy and (C 1 -C 6)alkylamino; and R d is (C 1 -C 6)alkyl, wherein the (C 1 -C 6)alkyl is optionally substituted with 1, 2, 3 or 4 substitutents independently selected from D, F, Cl, Br, CN, OR a, NR a R b,-(C 1 -C 4)alkylene-OR a and - (C 1 -C 4)alkylene-NR a R b.