A method for determining a Physical Uplink Share Channel, PUSCH, transmission power, the method implementable by a user equipment, UE, the method comprising: measuring reference signal received power; calculating downlink path loss by comparing the reference signal received power to a downlink transmit power from a next generation node B, gNB; obtaining parameters from the gNB; and determining the PUSCH transmission power P PUSCH,c ( i,j) for a PUSCH transmission of a serving cell c using parameter set configuration with index j in PUSCH transmission period i, based on a formula as follows: P PUSCH, c i j = min P CMAX, c i, 10 log 10 M PUSCH, c i + P O _ PUSCH, c j + α c j ⋅ PL c + Δ TF, c i + f c i, wherein P CMAX,c ( i) is a configured UE transmission power for the serving cell c in the PUSCH transmission period i, M PUSCH,c ( i)is bandwidth of PUSCH resource assignment expressed in number of resource blocks for PUSCH transmission period i, P O_PUSCH,c ( j)is a target power including the sum of a cell specific nominal component P O_NOMINAL_PUSCH,c ( j) and a UE specific component P O_UE_PUSCH,c ( j), α c ( j) is a scaling factor, PL c is a downlink, DL, path loss, Δ TF,c ( i) is a UE specific parameter for different types of traffic, and f c ( i) is PUSCH power control adjustment state for the PUSCH transmission period i; the method further comprising: calculating a numerology adjustment factor δ SCS as follows: δ SCS = 10 log SCS conf SCS default dB, wherein SCS conf is a configured subcarrier spacing for the PUSCH transmission and SCS default is default subcarrier spacing; and utilizing the numerology adjustment factor δ SCS as an additional parameter to determine the PUSCH transmission power as follows: P PUSCH, c i j = min P CMAX, c i, 10 log 10 M PUSCH, c i + δ SCS + P O _ PUSCH, c j + α c j ⋅ PL c + Δ TF, c i + f c i; determining a UL multiple access scheme of the PUSCH transmission; and setting a value of the nominal component P O_NOMINAL_PUSCH,c ( j) of the target power P O_PUSCH,c ( j) based on the determined UL multiple access scheme; wherein the multiple access scheme includes one or more of scheduled based orthogonal multiple access SB-OMA, non-orthogonal multiple access, NOMA, and grant free multiple access GRMA; and wherein interference levels of different multiple access schemes are different. measuring reference signal received power; calculating downlink path loss by comparing the reference signal received power to a downlink transmit power from a next generation node B, gNB; obtaining parameters from the gNB; and determining the PUSCH transmission power P PUSCH,c ( i,j) for a PUSCH transmission of a serving cell c using parameter set configuration with index j in PUSCH transmission period i, based on a formula as follows: P PUSCH, c i j = min P CMAX, c i, 10 log 10 M PUSCH, c i + P O _ PUSCH, c j + α c j ⋅ PL c + Δ TF, c i + f c i, wherein P CMAX,c ( i) is a configured UE transmission power for the serving cell c in the PUSCH transmission period i, M PUSCH,c ( i)is bandwidth of PUSCH resource assignment expressed in number of resource blocks for PUSCH transmission period i, P O_PUSCH,c ( j)is a target power including the sum of a cell specific nominal component P O_NOMINAL_PUSCH,c ( j) and a UE specific component P O_UE_PUSCH,c ( j), α c ( j) is a scaling factor, PL c is a downlink, DL, path loss, Δ TF,c ( i) is a UE specific parameter for different types of traffic, and f c ( i) is PUSCH power control adjustment state for the PUSCH transmission period i; the method further comprising: calculating a numerology adjustment factor δ SCS as follows: δ SCS = 10 log SCS conf SCS default dB, wherein SCS conf is a configured subcarrier spacing for the PUSCH transmission and SCS default is default subcarrier spacing; and utilizing the numerology adjustment factor δ SCS as an additional parameter to determine the PUSCH transmission power as follows: P PUSCH, c i j = min P CMAX, c i, 10 log 10 M PUSCH, c i + δ SCS + P O _ PUSCH, c j + α c j ⋅ PL c + Δ TF, c i + f c i; determining a UL multiple access scheme of the PUSCH transmission; and setting a value of the nominal component P O_NOMINAL_PUSCH,c ( j) of the target power P O_PUSCH,c ( j) based on the determined UL multiple access scheme; wherein the multiple access scheme includes one or more of scheduled based orthogonal multiple access SB-OMA, non-orthogonal multiple access, NOMA, and grant free multiple access GRMA; and wherein interference levels of different multiple access schemes are different. calculating a numerology adjustment factor δ SCS as follows: δ SCS = 10 log SCS conf SCS default dB, wherein SCS conf is a configured subcarrier spacing for the PUSCH transmission and SCS default is default subcarrier spacing; and utilizing the numerology adjustment factor δ SCS as an additional parameter to determine the PUSCH transmission power as follows: P PUSCH, c i j = min P CMAX, c i, 10 log 10 M PUSCH, c i + δ SCS + P O _ PUSCH, c j + α c j ⋅ PL c + Δ TF, c i + f c i; determining a UL multiple access scheme of the PUSCH transmission; and setting a value of the nominal component P O_NOMINAL_PUSCH,c ( j) of the target power P O_PUSCH,c ( j) based on the determined UL multiple access scheme; wherein the multiple access scheme includes one or more of scheduled based orthogonal multiple access SB-OMA, non-orthogonal multiple access, NOMA, and grant free multiple access GRMA; and wherein interference levels of different multiple access schemes are different.