Apparatus for the connection of one or more panels to a building element, comprising: - a support profile, provided with an anchor base fixed to an installation surface of said building element, a first and a second wing opposed to one other, between said wings (21, 22) and said base a cavity being thereby defined that acts as a seat for at least a portion or edge of said panel; - a laying set-up adjustment system of said panel with respect to said support profile, so as to adjust the inclination of said panel with respect to said building element or to panels adjacent thereto, said laying set-up adjustment system of said panel comprising an adjustment assembly, capable of imparting to said edge of said panel a controllable rotation around a fulcrum and of adjusting the inclination of said panel, wherein said adjustment assembly comprises: - an adjuster support, positioned close to said first wing, provided with at least two actuators, capable of operating on the opposing face of said panel and causing the rotation of at least said edge; - a stop plate, positioned close to said second wing, and provided with an abutment surface, capable of being associated in frontal coupling with the other face of said panel and shaped to define and identify said fulcrum of rotation of at least said edge; where of said at least two actuators there is identified: - at least one proximal actuator positioned in proximity to the base of said support profile; - at least one distal actuator positioned in the upper area of said support profile, close to the mouth of said cavity; wherein, by operating said proximal actuators and distal actuators, said adjuster support is deformed and made to translate crosswise inside said cavity so that it can operate on the opposite side of said panel and cause the rotation of at least its edge, characterised by the fact that said adjuster support comprises: - a greater number of proximal actuators than distal actuators, said arrangement being better adapted to respond to loads from the side of said first wing of said profile; or - a greater number of distal actuators than proximal actuators, said arrangement being better adapted to respond to loads from the side of said second wing of said profile said adjuster support being changeable in its orientation inside said profile. - a support profile, provided with an anchor base fixed to an installation surface of said building element, a first and a second wing opposed to one other, between said wings (21, 22) and said base a cavity being thereby defined that acts as a seat for at least a portion or edge of said panel; - a laying set-up adjustment system of said panel with respect to said support profile, so as to adjust the inclination of said panel with respect to said building element or to panels adjacent thereto, said laying set-up adjustment system of said panel comprising an adjustment assembly, capable of imparting to said edge of said panel a controllable rotation around a fulcrum and of adjusting the inclination of said panel, wherein said adjustment assembly comprises: - an adjuster support, positioned close to said first wing, provided with at least two actuators, capable of operating on the opposing face of said panel and causing the rotation of at least said edge; - a stop plate, positioned close to said second wing, and provided with an abutment surface, capable of being associated in frontal coupling with the other face of said panel and shaped to define and identify said fulcrum of rotation of at least said edge; - an adjuster support, positioned close to said first wing, provided with at least two actuators, capable of operating on the opposing face of said panel and causing the rotation of at least said edge; - a stop plate, positioned close to said second wing, and provided with an abutment surface, capable of being associated in frontal coupling with the other face of said panel and shaped to define and identify said fulcrum of rotation of at least said edge; where of said at least two actuators there is identified: - at least one proximal actuator positioned in proximity to the base of said support profile; - at least one distal actuator positioned in the upper area of said support profile, close to the mouth of said cavity; - at least one proximal actuator positioned in proximity to the base of said support profile; - at least one distal actuator positioned in the upper area of said support profile, close to the mouth of said cavity; wherein, by operating said proximal actuators and distal actuators, said adjuster support is deformed and made to translate crosswise inside said cavity so that it can operate on the opposite side of said panel and cause the rotation of at least its edge, characterised by the fact that said adjuster support comprises: - a greater number of proximal actuators than distal actuators, said arrangement being better adapted to respond to loads from the side of said first wing of said profile; or - a greater number of distal actuators than proximal actuators, said arrangement being better adapted to respond to loads from the side of said second wing of said profile - a greater number of proximal actuators than distal actuators, said arrangement being better adapted to respond to loads from the side of said first wing of said profile; or - a greater number of distal actuators than proximal actuators, said arrangement being better adapted to respond to loads from the side of said second wing of said profile said adjuster support being changeable in its orientation inside said profile.