A compound having the Formula IIIa, IVa, VIIa", VIIb", or VIIc" or or a pharmaceutically acceptable salt thereof, wherein p is 0 or 1 L 2 is a bond or is selected from CH 2, O, and CH 2 O, wherein the oxygen atom in CH 2 O is attached to a carbon atom on Cy 2; Cy 1 is aryl or heteroaryl each substituted with 1 to 3 groups independently selected from R 5; wherein at least one R 5 is -SO 2 -(C 1 -C 3)alkyl; Cy 2 is selected from aryl, heteroaryl, monocyclic cycloalkyl, and monocyclic heterocyclyl, wherein the aryl, heteroaryl, monocyclic cycloalkyl, and monocyclic heterocyclyl are each optionally substituted with 1 to 3 groups independently selected from R 6; R 2 is (C 1 -C 4)alkyl, (C 2 -C 4)alkenyl, (C 1 -C 4)haloalkyl, or monocyclic cycloalkyl; R 5 and R 6 are each independently selected from halogen, -CN, -OR c, -NR d R e, -S k R c, -NR c S 2 R c, -S 2 NR d R e, -C(=O)OR c, -OC(=O)OR c, -OC(=O)R c, -OC(=S)OR c, -C(=S)OR c, -OC(=S)R c, -C(=O)NR d R e, -NR c C(=O)R c, -C(=S)NR d R e, -NR c C(=S)R c, -NR c C(=O)OR c, -OC(=O)NR d R e, -NR c (C=S)OR c, -OC(=S)NR d R e, -NR c C(=O)NR d R e, -NR c (C=S)NR d R e, -C(=S)R c, -C(=O)R c, (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -NHC(=O)-heterocyclyl, -NHC(=O)-cycloalkyl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl portion present in each of said (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl substituent for R 6 are optionally substituted with halogen, OR c, -NO 2, -CN, -NR c C(=O)R c, -NR d R e, -S k R c, -C(=O)OR c, -C(=O)NR d R e, -C(=O)R c, (C 1 -C 3)alkyl, halo(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy, or halo(C 1 -C 3)alkoxy; each R c is independently selected from hydrogen and (C 1 -C 6)alkyl optionally substituted with hydroxy, (C 1 -C 2)alkoxy, -C NH 2, -C O(C 1 -C 3)alkyl, or 1 to 3 halogen; each R d and R e is independently selected from hydrogen and (C 1 -C 6)alkyl; k is 0, 1 or 2; any heterocyclyl or heteroaryl portion of Cy 1 or Cy 2 is further optionally substituted with =O; each instance of R 7 is independently hydrogen, OR c, -C(=O)OR c, monocyclic heterocyclyl, halophenyl, quinolin-2 one-4yl-methyl, or (C 1 -C 3)alkyl, wherein the (C 1 -C 3)alkyl is optionally substituted with OR c, -NR d R e, -C(=O)OR c, -C(=O)NR d R e, or halophenyl; and R 10 is (C 1 -C 4)alkyl or halo. p is 0 or 1 L 2 is a bond or is selected from CH 2, O, and CH 2 O, wherein the oxygen atom in CH 2 O is attached to a carbon atom on Cy 2; Cy 1 is aryl or heteroaryl each substituted with 1 to 3 groups independently selected from R 5; wherein at least one R 5 is -SO 2 -(C 1 -C 3)alkyl; Cy 2 is selected from aryl, heteroaryl, monocyclic cycloalkyl, and monocyclic heterocyclyl, wherein the aryl, heteroaryl, monocyclic cycloalkyl, and monocyclic heterocyclyl are each optionally substituted with 1 to 3 groups independently selected from R 6; R 2 is (C 1 -C 4)alkyl, (C 2 -C 4)alkenyl, (C 1 -C 4)haloalkyl, or monocyclic cycloalkyl; R 5 and R 6 are each independently selected from halogen, -CN, -OR c, -NR d R e, -S k R c, -NR c S 2 R c, -S 2 NR d R e, -C(=O)OR c, -OC(=O)OR c, -OC(=O)R c, -OC(=S)OR c, -C(=S)OR c, -OC(=S)R c, -C(=O)NR d R e, -NR c C(=O)R c, -C(=S)NR d R e, -NR c C(=S)R c, -NR c C(=O)OR c, -OC(=O)NR d R e, -NR c (C=S)OR c, -OC(=S)NR d R e, -NR c C(=O)NR d R e, -NR c (C=S)NR d R e, -C(=S)R c, -C(=O)R c, (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -NHC(=O)-heterocyclyl, -NHC(=O)-cycloalkyl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl portion present in each of said (C 1 -C 6)alkyl, cycloalkyl, -(CH 2) 1-4 -cycloalkyl, heterocyclyl, -(CH 2) 1-4 -heterocyclyl, aryl, -(CH 2) 1-4 -aryl, heteroaryl and -(CH 2) 1-4 -heteroaryl substituent for R 6 are optionally substituted with halogen, OR c, -NO 2, -CN, -NR c C(=O)R c, -NR d R e, -S k R c, -C(=O)OR c, -C(=O)NR d R e, -C(=O)R c, (C 1 -C 3)alkyl, halo(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy(C 1 -C 3)alkyl, (C 1 -C 3)alkoxy, or halo(C 1 -C 3)alkoxy; each R c is independently selected from hydrogen and (C 1 -C 6)alkyl optionally substituted with hydroxy, (C 1 -C 2)alkoxy, -C NH 2, -C O(C 1 -C 3)alkyl, or 1 to 3 halogen; each R d and R e is independently selected from hydrogen and (C 1 -C 6)alkyl; k is 0, 1 or 2; any heterocyclyl or heteroaryl portion of Cy 1 or Cy 2 is further optionally substituted with =O; each instance of R 7 is independently hydrogen, OR c, -C(=O)OR c, monocyclic heterocyclyl, halophenyl, quinolin-2 one-4yl-methyl, or (C 1 -C 3)alkyl, wherein the (C 1 -C 3)alkyl is optionally substituted with OR c, -NR d R e, -C(=O)OR c, -C(=O)NR d R e, or halophenyl; and R 10 is (C 1 -C 4)alkyl or halo.