A compound of Formula or a pharmaceutically acceptable salt thereof, wherein: - Z-X-Y is selected from the group consisting of: -N=C-NH-, -NH-C=N-, -O-C=N-, - S-C=N-, -N=C-O-, -N=C-S-, -CH=C-NH-, -CH=C-O-, -CH=C-S-, and -C -C=N-; - A is selected from the group consisting of: a bond, SO 2, CH 2, C=S, C=O, C=NR 9, and NR 9; - T is selected from the group consisting of: a double bond and - Z 1, Z 2, Z 3, and Z 4 are each independently selected from the group consisting of CR 8 and N; - R 1 is selected from the group consisting of: H and C 1 -C 6 alkoxy; - R 2 is selected from the group consisting of: C 1 -C 12 alkyloxy optionally substituted with one or more halogens, and C 2 -C 12 alkynyloxy; - R 3 is selected from the group consisting of F 2 HCF 2 CO, F 2 HCO, F 3 CO, and CHCCH 2 O; - R 4 is selected from the group consisting of: H and C 1 -C 6 alkoxy; - R 5 is H; - R 6 is selected from the group consisting of: H and C 1 -C 6 alkyl; - R 7 is selected from the group consisting of: H, CN, NO 2, and C 1 -C 6 alkyl; - R 8 is selected from the group consisting of: H, halogen, COOH, CONH 2, CONHOH, CONHCH 3, NH 2, SO 2 CH 3, SO 2 NH 2, SONHCH 3, and SON(CH 3) 2; - R 10 and R 11 are each independently selected from the group consisting of: H, halogen, OH, NO 2, CN, NH 2, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 2 -C 12 heterocycloalkyl, C 2 -C 12 heterocycloalkenyl, C 6 -C 18 aryl, C 1 -C 18 heteroaryl, C 1 -C 12 alkyloxy, C 2 -C 12 alkenyloxy, C 2 -C 12 alkynyloxy, C 1 -C 10 heteroalkyloxy, C 3 -C l2 cycloalkyloxy, C 3 -C 12 cycloalkenyloxy, C 1 -C 12 heterocycloalkyloxy, C 1 -C 12 heterocycloalkenyloxy, C 6 -C 18 aryloxy, C 1 -C 18 heteroary l oxy, C1 -C 12 alkylamino, SR 12, SO 3 H, SO 2 NR 13 R 14, SO 2 R 12, SONR 13 R 14, SOR 12, COR 12, COOH, COOR 12, CONR 13 R 14, NR 13 COR 12, NR 13 COOR 12, NR 13 SO 2 R 12, NR 13 CONR 14 R 15, NR 14 R 15, and acyl; - R 9, R 13, R 14, and R 15 are each independently selected from the group consisting of: H, an N-protecting group, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 1 -C 12 heterocycloalkyl, C 1 -C 12 heterocycloalkenyl, C 6 -C 18 aryl, and C 1 -C 18 heteroaryl; and - R 12 is selected from the group consisting of H, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 1 -C 12 heterocycloalkyl, C 1 -C 12 heterocycloalkenyl, C6-C 18 aryl, and C 1 -C 18 heteroaryl. - Z-X-Y is selected from the group consisting of: -N=C-NH-, -NH-C=N-, -O-C=N-, - S-C=N-, -N=C-O-, -N=C-S-, -CH=C-NH-, -CH=C-O-, -CH=C-S-, and -C -C=N-; - A is selected from the group consisting of: a bond, SO 2, CH 2, C=S, C=O, C=NR 9, and NR 9; - T is selected from the group consisting of: a double bond and - Z 1, Z 2, Z 3, and Z 4 are each independently selected from the group consisting of CR 8 and N; - R 1 is selected from the group consisting of: H and C 1 -C 6 alkoxy; - R 2 is selected from the group consisting of: C 1 -C 12 alkyloxy optionally substituted with one or more halogens, and C 2 -C 12 alkynyloxy; - R 3 is selected from the group consisting of F 2 HCF 2 CO, F 2 HCO, F 3 CO, and CHCCH 2 O; - R 4 is selected from the group consisting of: H and C 1 -C 6 alkoxy; - R 5 is H; - R 6 is selected from the group consisting of: H and C 1 -C 6 alkyl; - R 7 is selected from the group consisting of: H, CN, NO 2, and C 1 -C 6 alkyl; - R 8 is selected from the group consisting of: H, halogen, COOH, CONH 2, CONHOH, CONHCH 3, NH 2, SO 2 CH 3, SO 2 NH 2, SONHCH 3, and SON(CH 3) 2; - R 10 and R 11 are each independently selected from the group consisting of: H, halogen, OH, NO 2, CN, NH 2, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 2 -C 12 heterocycloalkyl, C 2 -C 12 heterocycloalkenyl, C 6 -C 18 aryl, C 1 -C 18 heteroaryl, C 1 -C 12 alkyloxy, C 2 -C 12 alkenyloxy, C 2 -C 12 alkynyloxy, C 1 -C 10 heteroalkyloxy, C 3 -C l2 cycloalkyloxy, C 3 -C 12 cycloalkenyloxy, C 1 -C 12 heterocycloalkyloxy, C 1 -C 12 heterocycloalkenyloxy, C 6 -C 18 aryloxy, C 1 -C 18 heteroary l oxy, C1 -C 12 alkylamino, SR 12, SO 3 H, SO 2 NR 13 R 14, SO 2 R 12, SONR 13 R 14, SOR 12, COR 12, COOH, COOR 12, CONR 13 R 14, NR 13 COR 12, NR 13 COOR 12, NR 13 SO 2 R 12, NR 13 CONR 14 R 15, NR 14 R 15, and acyl; - R 9, R 13, R 14, and R 15 are each independently selected from the group consisting of: H, an N-protecting group, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 1 -C 12 heterocycloalkyl, C 1 -C 12 heterocycloalkenyl, C 6 -C 18 aryl, and C 1 -C 18 heteroaryl; and - R 12 is selected from the group consisting of H, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 1 -C 10 heteroalkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl, C 1 -C 12 heterocycloalkyl, C 1 -C 12 heterocycloalkenyl, C6-C 18 aryl, and C 1 -C 18 heteroaryl.