A medicament delivery device comprising a housing (1100, 2100) and a safety member (1700, 2700, 3700) coupled to the housing, wherein: the housing (1100, 2100) contains at least a portion of a medicament container (1210, 2210), the medicament container defining a longitudinal axis, the housing including a housing surface defining a lock chamber (1150, 2155); wherein the safety member (1700, 2700, 3700)includes an outer surface and a lock protrusion (1706, 2706), the outer surface of the safety member being disposed outside of the housing, the safety member (1700, 2700, 3700) being removably coupled to the housing to move relative to the housing between a first position and a second position, the lock protrusion (1706, 2706) being disposed within the lock chamber (1150, 2155) of the housing when the safety member is in the first position to limit the delivery of a contents of the medicament container when the safety member (1700, 2700, 3700) is in the first position, and the lock protrusion (1706, 2706) being disposed outside of the lock chamber (1150, 2155) when the safety member is in the second position; wherein the medicament delivery device further comprises a lock member (1730, 2730) disposed within the lock chamber (1150, 2155) of the housing and configured to move along the housing surface defining ef the lock chamber (1150, 2155) when an orientation of the longitudinal axis of the medicament container changes, the lock member (1730, 2730) being positioned in contact with the lock protrusion (1706, 2706) of the safety member to limit movement of the safety member (1700, 2700, 3700) from the first position to the second position when the longitudinal axis of the medicament container (1210, 2210) is in a first orientation, the lock member (1730, 2730) being spaced apart from the lock protrusion (1706, 2706) when the longitudinal axis of the medicament container is in a second orientation to permit movement of the safety member (1700, 2700, 3700) from the first position to the second position. the housing (1100, 2100) contains at least a portion of a medicament container (1210, 2210), the medicament container defining a longitudinal axis, the housing including a housing surface defining a lock chamber (1150, 2155); wherein the safety member (1700, 2700, 3700)includes an outer surface and a lock protrusion (1706, 2706), the outer surface of the safety member being disposed outside of the housing, the safety member (1700, 2700, 3700) being removably coupled to the housing to move relative to the housing between a first position and a second position, the lock protrusion (1706, 2706) being disposed within the lock chamber (1150, 2155) of the housing when the safety member is in the first position to limit the delivery of a contents of the medicament container when the safety member (1700, 2700, 3700) is in the first position, and the lock protrusion (1706, 2706) being disposed outside of the lock chamber (1150, 2155) when the safety member is in the second position; wherein the medicament delivery device further comprises a lock member (1730, 2730) disposed within the lock chamber (1150, 2155) of the housing and configured to move along the housing surface defining ef the lock chamber (1150, 2155) when an orientation of the longitudinal axis of the medicament container changes, the lock member (1730, 2730) being positioned in contact with the lock protrusion (1706, 2706) of the safety member to limit movement of the safety member (1700, 2700, 3700) from the first position to the second position when the longitudinal axis of the medicament container (1210, 2210) is in a first orientation, the lock member (1730, 2730) being spaced apart from the lock protrusion (1706, 2706) when the longitudinal axis of the medicament container is in a second orientation to permit movement of the safety member (1700, 2700, 3700) from the first position to the second position.