A method for tiling production for a pair of boxes at an electronic packaging system, the electronic packaging system having packaging system characteristics, some of packaging system characteristics varying over time, the electronic packaging system including one or more packaging production machines, each packaging production machine having packaging machine characteristics, some of the packaging machine characteristics varying over time, each packaging production machine loaded with packaging material for producing boxes, the method comprising: accessing item data identifying a plurality of items that are to be packaged; determining packaging requirements for each of the plurality of items; selecting a pair of box sizes for tiled production at a packaging production machine, the pair of box sizes including a first box size for packaging a first one or more items in the plurality of items and including a second box size for packaging a second one or more items in the plurality of items, the pair of box sizes satisfying the packaging requirements for the first one or more items and second one or more items, the packaging production machine selected from among the one or more packaging production machines, including: at a specified time, collectively analyzing (a) the packaging requirements for each of the plurality of items, (b) the packing system characteristics, and (c) the packaging machine characteristics for each of the one or more packaging production machines; and determining how to allocate box production to the one or more packaging production machines for a period of time based on the collective analysis, including: matching the pair of box sizes to the packaging production machine based on the collective analysis; generating box production instructions in response to the selection, the box production instructions indicating how to tile production of a box of the first box size with a box of the second box size at the packaging production machine; and sending the box production instructions to the packaging production machine. accessing item data identifying a plurality of items that are to be packaged; determining packaging requirements for each of the plurality of items; selecting a pair of box sizes for tiled production at a packaging production machine, the pair of box sizes including a first box size for packaging a first one or more items in the plurality of items and including a second box size for packaging a second one or more items in the plurality of items, the pair of box sizes satisfying the packaging requirements for the first one or more items and second one or more items, the packaging production machine selected from among the one or more packaging production machines, including: at a specified time, collectively analyzing (a) the packaging requirements for each of the plurality of items, (b) the packing system characteristics, and (c) the packaging machine characteristics for each of the one or more packaging production machines; and determining how to allocate box production to the one or more packaging production machines for a period of time based on the collective analysis, including: matching the pair of box sizes to the packaging production machine based on the collective analysis; at a specified time, collectively analyzing (a) the packaging requirements for each of the plurality of items, (b) the packing system characteristics, and (c) the packaging machine characteristics for each of the one or more packaging production machines; and determining how to allocate box production to the one or more packaging production machines for a period of time based on the collective analysis, including: matching the pair of box sizes to the packaging production machine based on the collective analysis; matching the pair of box sizes to the packaging production machine based on the collective analysis; generating box production instructions in response to the selection, the box production instructions indicating how to tile production of a box of the first box size with a box of the second box size at the packaging production machine; and sending the box production instructions to the packaging production machine.