A compound of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomer or a tautomer thereof, wherein A is U is wherein X 8 to X 10 are independently selected from C-R 14 and N; G 1 and G 2 are independently selected from C and N; V 1 is selected from C-R 15, N, O and S; V 2 is selected from N, O, S and C-R 15; and W is V 4 - V 5, V 4 = V 5 or V 3, wherein V 3 to V 5 are independently selected from C-R 16, N, O and S, wherein V 4 connects with V 1; and V 5 connects with V 2; L is Q is each of which is unsubstituted or substituted with 1 to 3 R 4a groups; Z is each of which is unsubstituted or substituted with 1 to 3 R 5a groups; R 1 to R 3 are independently selected from H and C 1 -C 6 alkyl, wherein C 1 -C 6 alkyl is unsubstituted or substituted with 1 to 3 halide, -CN, -OH, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl, or C 1 -C 3 alkoxy groups; R 14 to R 16 are independently selected from H, halide, -CN, -OH, amino, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkylthio, wherein amino, C 1 -C 6 alkyl and C 1 -C 6 alkoxy are unsubstituted or substituted with 1 to 3 halide, C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl groups; R 4a and R 5a are independently selected from halide, -CN, and -OH, or R 4a and R 5a are independently selected from C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkylsulfonyl, C 1 -C 8 acyl, aminoacyl, C 1 -C 8 acylamino, C 1 -C 8 alkylcarbamoylamino, C 1 -C 8 alkoxycarbamoyl, C 1 -C 8 alkylsulfonamido, C 1 -C 8 alkylaminosulphonyl, C 2 -C 8 alkoxyacyl, and 3-8 membered heterocycle, all of which are unsubstituted or substituted with 1-3 halide, -OH, -CN, C 1 -C 3 alkyl, C 1 -C 3 alkoxyl or C 3 -C 8 cycloalkyl groups, wherein 3-8 membered heterocycle comprises one or more hetero atoms from N, O or S; R 2m is H, deuterium, tritium, halide, -OH, -CN, C 3 -C 8 cycloalkyl or C 1 -C 8 alkoxy; and R 4b and R 5b are independently selected from H, halide, -CN, amino, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, and C 1 -C 3 alkylamino. A is U is wherein X 8 to X 10 are independently selected from C-R 14 and N; G 1 and G 2 are independently selected from C and N; V 1 is selected from C-R 15, N, O and S; V 2 is selected from N, O, S and C-R 15; and W is V 4 - V 5, V 4 = V 5 or V 3, wherein V 3 to V 5 are independently selected from C-R 16, N, O and S, wherein V 4 connects with V 1; and V 5 connects with V 2; X 8 to X 10 are independently selected from C-R 14 and N; G 1 and G 2 are independently selected from C and N; V 1 is selected from C-R 15, N, O and S; V 2 is selected from N, O, S and C-R 15; and W is V 4 - V 5, V 4 = V 5 or V 3, wherein V 3 to V 5 are independently selected from C-R 16, N, O and S, wherein V 4 connects with V 1; and V 5 connects with V 2; L is Q is each of which is unsubstituted or substituted with 1 to 3 R 4a groups; Z is each of which is unsubstituted or substituted with 1 to 3 R 5a groups; R 1 to R 3 are independently selected from H and C 1 -C 6 alkyl, wherein C 1 -C 6 alkyl is unsubstituted or substituted with 1 to 3 halide, -CN, -OH, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl, or C 1 -C 3 alkoxy groups; R 14 to R 16 are independently selected from H, halide, -CN, -OH, amino, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkylthio, wherein amino, C 1 -C 6 alkyl and C 1 -C 6 alkoxy are unsubstituted or substituted with 1 to 3 halide, C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl groups; R 4a and R 5a are independently selected from halide, -CN, and -OH, or R 4a and R 5a are independently selected from C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkylsulfonyl, C 1 -C 8 acyl, aminoacyl, C 1 -C 8 acylamino, C 1 -C 8 alkylcarbamoylamino, C 1 -C 8 alkoxycarbamoyl, C 1 -C 8 alkylsulfonamido, C 1 -C 8 alkylaminosulphonyl, C 2 -C 8 alkoxyacyl, and 3-8 membered heterocycle, all of which are unsubstituted or substituted with 1-3 halide, -OH, -CN, C 1 -C 3 alkyl, C 1 -C 3 alkoxyl or C 3 -C 8 cycloalkyl groups, wherein 3-8 membered heterocycle comprises one or more hetero atoms from N, O or S; R 2m is H, deuterium, tritium, halide, -OH, -CN, C 3 -C 8 cycloalkyl or C 1 -C 8 alkoxy; and R 4b and R 5b are independently selected from H, halide, -CN, amino, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, and C 1 -C 3 alkylamino.