A distributed antenna system comprising: a remote antenna unit configured to communicate with wireless devices in a coverage area; one or more additional remote antenna units configured to communicate with wireless devices in one or more additional coverage areas; and a unit configured for communicating with the remote antenna unit and the one or more additional remote antenna units, the unit comprising a distributed antenna system controller that is configured to: determine that an undesirable signal component having a signal power exceeding a threshold power is communicated via an uplink path from the remote antenna unit; and minimize an impact of the undesirable signal component on the additional coverage areas of the one or more additional remote antenna units, wherein minimizing the impact comprises modifying the gain of the uplink path over which the undesirable signal component is communicated; wherein the undesirable signal component comprises an interfering signal received by the remote antenna unit and wherein the remote antenna unit comprises: a measurement receiver configured to measure the signal power of the interfering signal; a controller configured to: determine that the signal power of the interfering signal exceeds a threshold signal power; configure an attenuator disposed in the remote antenna unit to attenuate the interfering signal based on the signal power of the interfering signal; and generate a control message for the distributed antenna system controller, the control message identifying an amount of gain adjustment of the uplink path over which the interfering signal is communicated based on the signal power of the interfering signal; and wherein the distributed antenna system controller is configured to minimize the undesirable signal component by providing a control signal to a gain adjustment device of the unit, the control signal configuring the gain adjustment device to adjust the gain of the uplink path over which the interfering signal is communicated by the amount of gain adjustment. a remote antenna unit configured to communicate with wireless devices in a coverage area; one or more additional remote antenna units configured to communicate with wireless devices in one or more additional coverage areas; and a unit configured for communicating with the remote antenna unit and the one or more additional remote antenna units, the unit comprising a distributed antenna system controller that is configured to: determine that an undesirable signal component having a signal power exceeding a threshold power is communicated via an uplink path from the remote antenna unit; and minimize an impact of the undesirable signal component on the additional coverage areas of the one or more additional remote antenna units, wherein minimizing the impact comprises modifying the gain of the uplink path over which the undesirable signal component is communicated; determine that an undesirable signal component having a signal power exceeding a threshold power is communicated via an uplink path from the remote antenna unit; and minimize an impact of the undesirable signal component on the additional coverage areas of the one or more additional remote antenna units, wherein minimizing the impact comprises modifying the gain of the uplink path over which the undesirable signal component is communicated; a measurement receiver configured to measure the signal power of the interfering signal; a controller configured to: determine that the signal power of the interfering signal exceeds a threshold signal power; configure an attenuator disposed in the remote antenna unit to attenuate the interfering signal based on the signal power of the interfering signal; and generate a control message for the distributed antenna system controller, the control message identifying an amount of gain adjustment of the uplink path over which the interfering signal is communicated based on the signal power of the interfering signal; and determine that the signal power of the interfering signal exceeds a threshold signal power; configure an attenuator disposed in the remote antenna unit to attenuate the interfering signal based on the signal power of the interfering signal; and generate a control message for the distributed antenna system controller, the control message identifying an amount of gain adjustment of the uplink path over which the interfering signal is communicated based on the signal power of the interfering signal; and wherein the distributed antenna system controller is configured to minimize the undesirable signal component by providing a control signal to a gain adjustment device of the unit, the control signal configuring the gain adjustment device to adjust the gain of the uplink path over which the interfering signal is communicated by the amount of gain adjustment.