mhurhangee/ep-ind-claims huggingface dataset:
Digital input circuit for receiving digital input signals of at least one signal generator, comprising - a first subcircuit with a first digital input, via which a first digital input signal can be supplied to the first subcircuit, and with a first threshold value element, by means of which a logic state of the first subcircuit can be determined, wherein the first subcircuit adopts a first state, when the first digital input signal reaches or falls below a lower threshold, and wherein the first subcircuit adopts a second state, when the first digital input signal reaches or exceeds an upper threshold, and - at least one second subcircuit with a second digital input, via which a second digital input signal can be supplied to the second subcircuit, and with a second threshold value element, by means of which a logic state of the second subcircuit can be determined, wherein the second subcircuit adopts a first state, when the second digital input signal reaches or falls below a lower threshold, and wherein the second subcircuit adopts a second state, when the second digital input signal reaches or exceeds an upper threshold, characterised in that the digital input circuit has a combined test and current boosting device, which is configured to generate a driving signal such that a function test of the two subcircuits (14, 14') is performed simultaneously with the driving signal and an input current of the digital inputs (10, 10') is increased, wherein each of the two subcircuits (14, 14') has a current limiting device (15, 15') with a transistor (150, 150'), and wherein the subcircuits (14, 14') are configured so that on receiving the driving signal of the combined test and current boosting device for testing the subcircuits (14, 14') the levels of the digital input signals, which are supplied via the digital inputs (10, 10') to the subcircuits (14, 14'), are lowered internally so far by means of the transistors (150, 150') that they correspond to the first state of the relevant subcircuit (14, 14'), and an increased input current flows via the transistors (150, 150'). - a first subcircuit with a first digital input, via which a first digital input signal can be supplied to the first subcircuit, and with a first threshold value element, by means of which a logic state of the first subcircuit can be determined, wherein the first subcircuit adopts a first state, when the first digital input signal reaches or falls below a lower threshold, and wherein the first subcircuit adopts a second state, when the first digital input signal reaches or exceeds an upper threshold, and - at least one second subcircuit with a second digital input, via which a second digital input signal can be supplied to the second subcircuit, and with a second threshold value element, by means of which a logic state of the second subcircuit can be determined, wherein the second subcircuit adopts a first state, when the second digital input signal reaches or falls below a lower threshold, and wherein the second subcircuit adopts a second state, when the second digital input signal reaches or exceeds an upper threshold,
A positioning method including the steps of: calculating a lower accuracy positioning solution; applying an offset to the lower accuracy positioning solution to form a final positioning solution if a higher accuracy positioning solution is unavailable, whereby the offset is a difference between the lower accuracy positioning solution at the last epoch when the higher accuracy positioning solution was last available and the higher accuracy positioning solution at the last epoch when the higher accuracy positioning solution was last available; continuously determining whether the higher accuracy positioning solution has again become available; and characterised in that in the event that the higher accuracy positioning solution has become available; calculating the higher accuracy positioning solution; applying a reacquisition offset to the higher accuracy positioning solution to form an adjusted higher accuracy positioning solution; and setting the adjusted higher accuracy position solution as a new final positioning solution, wherein the reacquisition offset is a difference between the final positioning solution at the current epoch and the higher accuracy positioning solution. calculating a lower accuracy positioning solution; applying an offset to the lower accuracy positioning solution to form a final positioning solution if a higher accuracy positioning solution is unavailable, whereby the offset is a difference between the lower accuracy positioning solution at the last epoch when the higher accuracy positioning solution was last available and the higher accuracy positioning solution at the last epoch when the higher accuracy positioning solution was last available; continuously determining whether the higher accuracy positioning solution has again become available; and characterised in that in the event that the higher accuracy positioning solution has become available; calculating the higher accuracy positioning solution; applying a reacquisition offset to the higher accuracy positioning solution to form an adjusted higher accuracy positioning solution; and setting the adjusted higher accuracy position solution as a new final positioning solution, wherein the reacquisition offset is a difference between the final positioning solution at the current epoch and the higher accuracy positioning solution.
Filter device for transmission oil, having a filter element which can be inserted into a transmission oil pan and the filter medium of which separates an unfiltered medium side from a filtrate chamber, which filtrate chamber is connected in a fluid-conducting manner to an outlet to which a vacuum conveying device, such as a suction oil pump, can be connected, wherein the filter medium of the filter element comprises at least one structural layer with a predefinable surface area and with predefinable filter properties and at least one further structural layer with predefinable filter properties, wherein the surface area of the further structural layer is different from the surface area of the first structural layer, wherein the individual structural layers (44, 46) enclose an inner filter cavity, wherein the individual structural layers (44, 46) are pleated with the same type of pleats, and wherein the pleated structural layers (44, 46) extend in axial orientation between two end caps (22, 34) of the filter element, characterised in that, viewed in the direction of flow of the fluid flow to be cleaned, the respective structural layer with the higher filter fineness follows a preceding structural layer with a lower filter fineness in each case, and in that the filter element is accommodated in the oil pan in an inner housing which comprises an inlet leading to the inner filter cavity, a filtrate chamber surrounding the filter element and a fluid outlet leading from said filtrate chamber to a suction connection.
A method to form a remodelled and functionalized antibody using a synthetic oligosaccharide oxazoline having a predetermined oligosaccharide component with a defined number of saccharide mannose residues and glycosidic linkage types, the method comprising: (a) providing an antibody substrate comprising at least two N-acetylglucosamine (GlcNAc) residues with a GlcNAc-GlcNAc bond; (b) treating the antibody substrate with an endoglycosidase enzyme to hydrolyze the bond between the two GlcNAc residues positioned closest to the peptide thereby forming an acceptor GlcNAc-containing antibody substrate with a single GlcNAc-moiety, wherein the single GlcNAc moiety is positioned on the Fc region of the antibody; (c) reacting the synthetic oligosaccharide oxazoline with the single GlcNAc moiety in the presence of an endoglycosidase (ENGase) selected from the group consisting of Endo A and Endo M thereby adding the predetermined oligosaccharide component to form a remodelled antibody; and (d) adding an additional tag to a mannose saccharide residue of the synthetic oligosaccharide oxazoline either before reacting with the single GlcNAc moiety or to the remodelled antibody of step (c) to form the functionalised antibody, wherein the tag is an antigen, drug, toxin, fluorescent probe, biotin, a PEG species, lipid, nucleotides or polypeptide. (a) providing an antibody substrate comprising at least two N-acetylglucosamine (GlcNAc) residues with a GlcNAc-GlcNAc bond; (b) treating the antibody substrate with an endoglycosidase enzyme to hydrolyze the bond between the two GlcNAc residues positioned closest to the peptide thereby forming an acceptor GlcNAc-containing antibody substrate with a single GlcNAc-moiety, wherein the single GlcNAc moiety is positioned on the Fc region of the antibody; (c) reacting the synthetic oligosaccharide oxazoline with the single GlcNAc moiety in the presence of an endoglycosidase (ENGase) selected from the group consisting of Endo A and Endo M thereby adding the predetermined oligosaccharide component to form a remodelled antibody; and (d) adding an additional tag to a mannose saccharide residue of the synthetic oligosaccharide oxazoline either before reacting with the single GlcNAc moiety or to the remodelled antibody of step (c) to form the functionalised antibody, wherein the tag is an antigen, drug, toxin, fluorescent probe, biotin, a PEG species, lipid, nucleotides or polypeptide.
A process of making O,O-dimethyl phosphoroamidothioate comprising, a. reacting sulfur with PCl 3 to form PSCl 3, b. reacting the PSCl 3 formed with methanol to form O-methyl phosphorodichloridothioate, c. reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH 2 Cl 2, wherein methyl lye is prepared by reaction of pre-chilled (0-5°C) methanol (1.1 equivalent) with aqueous sodium hydroxide (1.1 equivalent) under an inert atmosphere, and d. reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH 2 Cl 2, wherein the O,O-dimethyl phosphorochloridothioate and O, O-dimethyl phosphoramidothioate formed is maintained throughout the process in solution in CH 2 Cl 2 at all times. a. reacting sulfur with PCl 3 to form PSCl 3, b. reacting the PSCl 3 formed with methanol to form O-methyl phosphorodichloridothioate, c. reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CH 2 Cl 2, wherein methyl lye is prepared by reaction of pre-chilled (0-5°C) methanol (1.1 equivalent) with aqueous sodium hydroxide (1.1 equivalent) under an inert atmosphere, and d. reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CH 2 Cl 2,
A system for storing and retrieving the calories contained in a heat-transfer fluid, this system comprising: - a series of adjoining and insulated tanks, said series comprising at least a first tank and a last tank and at least one intermediate tank (220, 230, 240, 250) between the first tank and the last tank; - each tank (210, 220, 230, 240, 250) in said series, except for the last tank comprising a pipe connecting the upper part of said tank to the lower part of the next intermediate tank in said series; and - a retrieval exchanger, supplying thermal energy and capable of heating the heat-transfer fluid, the said exchanger having a circuit for circulating the said heat-transfer fluid, one inlet of which is connected to the upper part of the last tank and the outlet of which is connected to the lower part of the first tank; the said system being characterized in that it includes - a storage exchanger, which consumes thermal energy and is capable of heating the heat-transfer fluid, said exchanger having a circuit for circulating said heat-transfer fluid, one inlet of which is connected to the lower part of the first tank and the outlet of which is connected to the lower part of the last tank. - a series of adjoining and insulated tanks, said series comprising at least a first tank and a last tank and at least one intermediate tank (220, 230, 240, 250) between the first tank and the last tank; - each tank (210, 220, 230, 240, 250) in said series, except for the last tank comprising a pipe connecting the upper part of said tank to the lower part of the next intermediate tank in said series; and - a retrieval exchanger, supplying thermal energy and capable of heating the heat-transfer fluid, the said exchanger having a circuit for circulating the said heat-transfer fluid, one inlet of which is connected to the upper part of the last tank and the outlet of which is connected to the lower part of the first tank; the said system being characterized in that it includes - a storage exchanger, which consumes thermal energy and is capable of heating the heat-transfer fluid, said exchanger having a circuit for circulating said heat-transfer fluid, one inlet of which is connected to the lower part of the first tank and the outlet of which is connected to the lower part of the last tank.
A filter candle element for the dedusting of industrial gases, comprising a filter body which is composed of inorganic fibers, and comprising a mineral additive which is accumulated to the inorganic fibers, wherein the mineral additive comprises zeolite.
Self-propelled construction machine comprising a machine frame supported by a chassis having wheels or crawler tracks (3, 4), a milling drum arranged on the machine frame for machining the ground, a drive device for driving the wheels or crawler tracks (3, 4) and the milling drum, a lifting device for adjusting the height of the milling drum with respect to the surface of the ground to be machined, a control and processing unit, which is configured in such a way that a particular advance speed (v), at which the construction machine moves in the terrain, a particular milling drum rotational speed (n), at which the milling drum rotates, and a particular height of the milling drum with respect to the surface of the ground to be machined are adjustable such that material is removed from the ground leading to a milled track having a particular milling profil, the control and processing unit being configured in such a way that a variable (Δ) which is characteristic of the milling profile is determined on the basis of a functional relationship between the variable which is characteristic of the milling profile and the advance speed (v) and/or the milling drum rotational speed (n, characterised in that the variable (Δ) which is characteristic of the milling profile is a correction variable for a specified milling depth (h), the control and processing unit being configured in such a way that, instead of the specified milling depth (h), a value that is corrected using the correction variable is set for the milling depth.
A surgical instrument comprising: a handle assembly comprising a proximal section, an intermediate section, and a distal section, the proximal section forming a first aperture and the distal section forming a second aperture; a tip assembly comprising a proximal end extending through the second aperture to a distal tip comprising an articulating portion; one or more control wires disposed internally to the handle assembly and the tip assembly and coupled to the articulating portion; an articulation control (28, 30) extending through the first aperture, the articulation control being actuatable between a plurality of positions to deflect the articulating portion; and one or more guides operable to interact with the one or more control wires during actuation of the articulation control (28, 30), wherein a first longitudinal axis of the proximal section of the handle assembly is offset from a second longitudinal axis of the distal section of the handle assembly wherein the one or more guides are positioned internally in the handle assembly, wherein the one or more guides are one or more posts. a handle assembly comprising a proximal section, an intermediate section, and a distal section, the proximal section forming a first aperture and the distal section forming a second aperture; a tip assembly comprising a proximal end extending through the second aperture to a distal tip comprising an articulating portion; one or more control wires disposed internally to the handle assembly and the tip assembly and coupled to the articulating portion; an articulation control (28, 30) extending through the first aperture, the articulation control being actuatable between a plurality of positions to deflect the articulating portion; and one or more guides operable to interact with the one or more control wires during actuation of the articulation control (28, 30), wherein a first longitudinal axis of the proximal section of the handle assembly is offset from a second longitudinal axis of the distal section of the handle assembly wherein the one or more guides are positioned internally in the handle assembly, wherein the one or more guides are one or more posts.
A pump system, comprising: a pair of pumps (3A, 3B), each of which contains a vibration actuator having a movable body which can perform reciprocating rotation around a shaft portion by electromagnetic drive and can discharge fluid due to drive of the vibration actuator, wherein: each of the pair of pumps (3A, 3B) can be vibrated by the reciprocating rotation of the movable body, characterized in that: the pump system has: a vibration suppression mode in which the pair of pumps (3A 3B) are respectively driven by AC voltages whose phases are shifted from each other by 180°, a first vibration generation mode in which the pair of pumps (3A 3B) are respectively driven by in-phase AC voltages, and a second vibration generation mode in which the pair of pumps (3A, 3B) are respectively driven by AC voltages whose phases are shifted from each other by 90°. a pair of pumps (3A, 3B), each of which contains a vibration actuator having a movable body which can perform reciprocating rotation around a shaft portion by electromagnetic drive and can discharge fluid due to drive of the vibration actuator, wherein: each of the pair of pumps (3A, 3B) can be vibrated by the reciprocating rotation of the movable body, characterized in that: the pump system has: a vibration suppression mode in which the pair of pumps (3A 3B) are respectively driven by AC voltages whose phases are shifted from each other by 180°, a first vibration generation mode in which the pair of pumps (3A 3B) are respectively driven by in-phase AC voltages, and a second vibration generation mode in which the pair of pumps (3A, 3B) are respectively driven by AC voltages whose phases are shifted from each other by 90°. a vibration suppression mode in which the pair of pumps (3A 3B) are respectively driven by AC voltages whose phases are shifted from each other by 180°, a first vibration generation mode in which the pair of pumps (3A 3B) are respectively driven by in-phase AC voltages, and a second vibration generation mode in which the pair of pumps (3A, 3B) are respectively driven by AC voltages whose phases are shifted from each other by 90°.
A tank for a machine for the production of hot drinks comprising: - a vessel suitable for containing water to be supplied to the machine for the production of hot drinks; - a connecting element which connects the vessel to a feed circuit of the machine for the production of hot drinks; - housing means for removably housing a cartridge filter; characterised in that it comprises positioning means (7; 7'; 7"; 72) for removably fixing a conveyor element to the vessel, the conveyor element being suitable for covering the filter at an inlet section for the water to enter the filter, leaving a passage for the water defined between the vessel and the conveyor element, a feed channel being further defined between the conveyor element and the filter so as to allow a flow of water from the vessel towards the inlet section. - a vessel suitable for containing water to be supplied to the machine for the production of hot drinks; - a connecting element which connects the vessel to a feed circuit of the machine for the production of hot drinks; - housing means for removably housing a cartridge filter; characterised in that it comprises positioning means (7; 7'; 7"; 72) for removably fixing a conveyor element to the vessel, the conveyor element being suitable for covering the filter at an inlet section for the water to enter the filter, leaving a passage for the water defined between the vessel and the conveyor element, a feed channel being further defined between the conveyor element and the filter so as to allow a flow of water from the vessel towards the inlet section.
A combination for use as a medicament, the combination comprising: a) a therapeutically effective amount of hypomethylating agent selected from azacitidine, decitabine, or a combination thereof; and b) a therapeutically effective amount of sulforaphane, resveratrol and curcumin. a) a therapeutically effective amount of hypomethylating agent selected from azacitidine, decitabine, or a combination thereof; and b) a therapeutically effective amount of sulforaphane, resveratrol and curcumin.
A kneading device comprising: a kneading chamber for accommodating materials to be kneaded; and a pair of rotors for being rotated in the kneading chamber and kneading the materials to be kneaded by a plurality of kneading blades, wherein when each rotor is developed into a planar state, the plurality of kneading blades in each rotor is composed only of inclined blades inclined to the same direction in a rotational direction of the rotor with respect to an axial direction of the rotor; wherein, in each rotor: the rotor has a long bent blade and a short bent blade which are bent at respective bent portions (31, 41) to change its respective tilt angle with respect to the axial direction of the rotor in the plurality of kneading blades; characterized in that both end portions (21, 22) of the long bent blade are located on the end portions (12, 13) of the rotor; an end portion of the short bent blade is formed at a position away from the end portions (12, 13) of the rotor and is located between one end portion and the other end portion of the rotor; and on an outer periphery of the rotor, a passage portion through which the materials to be kneaded can pass is provided between one end portion of the rotor and the one end portion of the short bent blade. a kneading chamber for accommodating materials to be kneaded; and a pair of rotors for being rotated in the kneading chamber and kneading the materials to be kneaded by a plurality of kneading blades, wherein when each rotor is developed into a planar state, the plurality of kneading blades in each rotor is composed only of inclined blades inclined to the same direction in a rotational direction of the rotor with respect to an axial direction of the rotor; wherein, in each rotor: the rotor has a long bent blade and a short bent blade which are bent at respective bent portions (31, 41) to change its respective tilt angle with respect to the axial direction of the rotor in the plurality of kneading blades; characterized in that both end portions (21, 22) of the long bent blade are located on the end portions (12, 13) of the rotor; an end portion of the short bent blade is formed at a position away from the end portions (12, 13) of the rotor and is located between one end portion and the other end portion of the rotor; and on an outer periphery of the rotor, a passage portion through which the materials to be kneaded can pass is provided between one end portion of the rotor and the one end portion of the short bent blade.