A method for closing a plurality of pre-crimped cartridges for use in pharmaceutical, medical or cosmetic applications, said pre-crimped cartridges having an upper end and a bottom end opposite to the upper end, a cylindrical body with a filling opening at the bottom end, and a shoulder portion at the upper end, which is followed by a widened upper rim with a secondary opening for drug administering, wherein the secondary opening is sealed by a seal and an outer closure is crimped over the widened upper rim to secure the seal at the pre-crimped cartridge, said method comprising: providing a supporting structure for closures having a plurality of tubular receptacles disposed in a regular arrangement, wherein the receptacles releasably accommodate a plurality of closures at least partially and comprise retaining structures (66, 67) for releasably engaging with the closures for retaining the closures in the receptacles; providing a supporting structure for cartridges having a plurality of tubular receptacles disposed in the same regular arrangement, which are formed by circumferential side-walls protruding downward from a bottom side of a supporting plate of the supporting structure for cartridges and which accommodate a plurality of pre-crimped cartridges, wherein retaining protrusions are formed at the bottom ends of the receptacles protruding inward and the pre-crimped cartridges are accommodated upside-down in the receptacles so that the shoulder portions of the pre-crimped cartridges are supported on the retaining protrusions of the receptacles and the sealed upper ends of the pre-crimped cartridges extend through central openings formed by the retaining protrusions at the bottom ends of the receptacles; disposing the supporting structure for closures above the supporting structure for cartridges in an environment with reduced pressure so that the receptacles of the supporting structure for closures are aligned with the receptacles of the supporting structure for cartridges; and pushing the closures downward out of the receptacles of the supporting structure for closures and into the filling openings at the bottoms ends of the pre-crimped cartridges, while the pre-crimped cartridges are accommodated in the receptacles of the supporting structure for cartridges. providing a supporting structure for closures having a plurality of tubular receptacles disposed in a regular arrangement, wherein the receptacles releasably accommodate a plurality of closures at least partially and comprise retaining structures (66, 67) for releasably engaging with the closures for retaining the closures in the receptacles; providing a supporting structure for cartridges having a plurality of tubular receptacles disposed in the same regular arrangement, which are formed by circumferential side-walls protruding downward from a bottom side of a supporting plate of the supporting structure for cartridges and which accommodate a plurality of pre-crimped cartridges, wherein retaining protrusions are formed at the bottom ends of the receptacles protruding inward and the pre-crimped cartridges are accommodated upside-down in the receptacles so that the shoulder portions of the pre-crimped cartridges are supported on the retaining protrusions of the receptacles and the sealed upper ends of the pre-crimped cartridges extend through central openings formed by the retaining protrusions at the bottom ends of the receptacles; disposing the supporting structure for closures above the supporting structure for cartridges in an environment with reduced pressure so that the receptacles of the supporting structure for closures are aligned with the receptacles of the supporting structure for cartridges; and pushing the closures downward out of the receptacles of the supporting structure for closures and into the filling openings at the bottoms ends of the pre-crimped cartridges, while the pre-crimped cartridges are accommodated in the receptacles of the supporting structure for cartridges.