A compound of Formula, and its pharmaceutically acceptable salts or stereoisomers thereof: wherein R 1 represents 6-7-membered nitrogen-containing hetero fused ring group, 7-12-membered nitrogen-containing hetero spiro ring group, or 7-12-membered nitrogen-containing hetero bridged ring group, each of which is linked to pyrimidine ring via N and is unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, cyano, amino, hydroxy, C 1-6 alkyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylcarbonyl or C 1-6 alkoxycarbonyl; R 2 represents hydrogen atom, hydroxy, amino, cyano, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 1-6 alkyl, haloC 1-6 alkyl, hydroxy C 1-6 alkyl or C 1-6 alkoxy; R 3 and R 4 each independently represent hydrogen atom or -M-R 7, M represents a single bond, or C 1-6 alkylidene (-(CH 2) t -(t is an integer from 1 to 6)) unsubstituted or substituted with 1-4 substituents, R 7 represents a cyclic group other than adamantyl, which is unsubstituted or substituted with 1-4 substituents, or R 3 and R 4 together with the nitrogen atom to which they link form a 5-7-membered nitrogen-containing hetero ring group unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, hydroxy, cyano, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, oxo, C 1-6 alkyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl or di(C 1-6 alkyl)phosphino; R 5 represents hydrogen atom or -Q-R 8, Q represents a single bond, or C 1-6 alkylidene (-(CH 2) t -(t is an integer from 1 to 6)) unsubstituted or substituted with 1-4 substituents, R 8 represents 6-14-membered aryl, 5-7-membered heteromonocyclic group or 6-14-membered fused ring group, each of which is unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, hydroxy, C 1-6 alkyl, haloC 1-6 alkyl, carboxylC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-8 alkoxy, haloC 1-8 alkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, cyano, nitro, C 1-6 alkylcarbonyl, sulfonylamino or C 1-6 alkylsulfonylamino. R 1 represents 6-7-membered nitrogen-containing hetero fused ring group, 7-12-membered nitrogen-containing hetero spiro ring group, or 7-12-membered nitrogen-containing hetero bridged ring group, each of which is linked to pyrimidine ring via N and is unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, cyano, amino, hydroxy, C 1-6 alkyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylcarbonyl or C 1-6 alkoxycarbonyl; R 2 represents hydrogen atom, hydroxy, amino, cyano, C 1-6 alkylamino, di(C 1-6 alkyl)amino, C 1-6 alkyl, haloC 1-6 alkyl, hydroxy C 1-6 alkyl or C 1-6 alkoxy; R 3 and R 4 each independently represent hydrogen atom or -M-R 7, M represents a single bond, or C 1-6 alkylidene (-(CH 2) t -(t is an integer from 1 to 6)) unsubstituted or substituted with 1-4 substituents, R 7 represents a cyclic group other than adamantyl, which is unsubstituted or substituted with 1-4 substituents, or R 3 and R 4 together with the nitrogen atom to which they link form a 5-7-membered nitrogen-containing hetero ring group unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, hydroxy, cyano, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, oxo, C 1-6 alkyl, hydroxyC 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkylsulfonyl or di(C 1-6 alkyl)phosphino; R 5 represents hydrogen atom or -Q-R 8, Q represents a single bond, or C 1-6 alkylidene (-(CH 2) t -(t is an integer from 1 to 6)) unsubstituted or substituted with 1-4 substituents, R 8 represents 6-14-membered aryl, 5-7-membered heteromonocyclic group or 6-14-membered fused ring group, each of which is unsubstituted or substituted with 1-4 substituents, the substituents are selected from halogen atoms, hydroxy, C 1-6 alkyl, haloC 1-6 alkyl, carboxylC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-8 alkoxy, haloC 1-8 alkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, cyano, nitro, C 1-6 alkylcarbonyl, sulfonylamino or C 1-6 alkylsulfonylamino.