A compound which is of Formula: wherein R 1 is -NR 5 R 5a; R 2a is halo or C 1 -C 6 alkyl; R 2 is -S-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or halo; and when R 3, R 3a, and R 3b are hydrogen, then R 2 is C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or -S-C 1 -C 6 alkyl; X is -S-; R 3, R 3a, and R 3b are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -S-C 1 -C 6 alkyl, halo, C 1 -C 6 alkoxy; C 3 -C 8 -cycloalkyloxy; heterocycloalkyloxy; heteroaryloxy, or phenoxy wherein each phenyl and heteroaryl is independently optionally substituted with 1, 2, or 3 R 6; R 5 is -OR 5b; R 5a is hydrogen; R 5b is C 3 -C 8 cycloalkyl-C 1 -C 6 -alkyl or an unbranched C 1 -C 6 hydroxyalkyl, wherein the C 1 -C 6 alkyl in C 1 -C 6 hydroxyalkyl is substituted with one hydroxy; each R 6 is independently selected from the group consisting of carboxy, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, heterocycloalkyl, -OC R 7, -OS 2 R 7, -O-C 1 -C 6 -haloalkyl, C 3 -C 8 cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, -NR 8a S 2 R 8, -NR 8a C R 8, -S 2 R 8, -S 2 NR 8a R 8, -C R 8, -C NR 8a R 8, and -C 1 -C 6 -alkylene-R 6a; each R 6a is independently selected from the group consisting of C 3 -C 8 cycloalkyl, heterocycloalkyl, -NH 2, -NH(C 1 -C 6 -alkyl), -N(C 1 -C 6 -alkyl) 2, -NR 9a S 2 R 9, - NR 9a C R 9, -S 2 R 9, -S 2 NR 9a R 9, -C R 9, and -C NR 9a R 9; each R 7 is independently selected from the group consisting of amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 -alkoxy, heterocycloalkyl, aryl, and heteroaryl; each R 8a and R 9a is independently H or C 1-6 alkyl; and each R 8 and R 9 is independently C 1 -C 6 alkyl, aryl, heteroaryl, C 3 -C 8 cycloalkyl, or heterocycloalkyl; or is an N-oxide, a stereoisomer, mixture of stereoisomers, and/or a pharmaceutically acceptable salt thereof. R 1 is -NR 5 R 5a; R 2a is halo or C 1 -C 6 alkyl; R 2 is -S-C 1 -C 6 alkyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or halo; and when R 3, R 3a, and R 3b are hydrogen, then R 2 is C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or -S-C 1 -C 6 alkyl; X is -S-; R 3, R 3a, and R 3b are independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -S-C 1 -C 6 alkyl, halo, C 1 -C 6 alkoxy; C 3 -C 8 -cycloalkyloxy; heterocycloalkyloxy; heteroaryloxy, or phenoxy wherein each phenyl and heteroaryl is independently optionally substituted with 1, 2, or 3 R 6; R 5 is -OR 5b; R 5a is hydrogen; R 5b is C 3 -C 8 cycloalkyl-C 1 -C 6 -alkyl or an unbranched C 1 -C 6 hydroxyalkyl, wherein the C 1 -C 6 alkyl in C 1 -C 6 hydroxyalkyl is substituted with one hydroxy; each R 6 is independently selected from the group consisting of carboxy, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 8 cycloalkyl, heterocycloalkyl, -OC R 7, -OS 2 R 7, -O-C 1 -C 6 -haloalkyl, C 3 -C 8 cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, -NR 8a S 2 R 8, -NR 8a C R 8, -S 2 R 8, -S 2 NR 8a R 8, -C R 8, -C NR 8a R 8, and -C 1 -C 6 -alkylene-R 6a; each R 6a is independently selected from the group consisting of C 3 -C 8 cycloalkyl, heterocycloalkyl, -NH 2, -NH(C 1 -C 6 -alkyl), -N(C 1 -C 6 -alkyl) 2, -NR 9a S 2 R 9, - NR 9a C R 9, -S 2 R 9, -S 2 NR 9a R 9, -C R 9, and -C NR 9a R 9; each R 7 is independently selected from the group consisting of amino, C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 -alkoxy, heterocycloalkyl, aryl, and heteroaryl; each R 8a and R 9a is independently H or C 1-6 alkyl; and each R 8 and R 9 is independently C 1 -C 6 alkyl, aryl, heteroaryl, C 3 -C 8 cycloalkyl, or heterocycloalkyl; or is an N-oxide, a stereoisomer, mixture of stereoisomers, and/or a pharmaceutically acceptable salt thereof.