mhurhangee/ep-ind-claims huggingface dataset:
A liquid, viscous or dry rehydratable preparation comprising homogenised mealworm or lesser mealworm larvae and a chicken egg protein as binding agent whereby the preparation contains 9 to 17 gram dry chicken egg protein per 100 gram wet weight homogenised mealworm or lesser mealworm larvae.
Adhesive valve that comprises a flexible label (1; 11; 21; 31) having an upper surface and a lower surface which is provided with adhesive, wherein a flexible membrane (2; 12; 22; 32) is applied to the lower surface of the flexible label (1; 11; 21; 31) and has a substantially non-adhesive lower surface, wherein the lower surface of the flexible label (1; 11; 21; 31) is suitable to be joined to a further surface by means of said adhesive so that the flexible membrane (2; 12; 22; 32) is arranged between the flexible label (1; 11; 21; 31) and this further surface, wherein the flexible label (1; 11; 21; 31) has at least one incision (1b; 11b; 21b; 31b) that connects the two surfaces of the flexible label (1; 11; 21; 31) at the flexible membrane (2; 12; 22; 32), wherein at least one incision (4; 14; 24; 34) connects the two surfaces of the flexible membrane (2; 12; 22; 32) and is covered by the flexible label (1; 11; 21; 31), characterized in that the incision (4; 14; 24; 34) in the flexible membrane (2; 12; 22; 32) forms in the flexible membrane (2; 12; 22; 32) at least one tongue-shaped portion (2c; 12c; 22c; 32c).
A removable anode assembly for an ion source with a base assembly, the anode assembly comprising a pole piece removably attached to the base assembly; a thermally conductive plate having a gas duct and at least one channel extending from the gas duct to a position radially outward of the gas duct; a gas distributor removably attached to the thermally conductive plate; and an anode removably attached to the thermally conductive plate and the pole piece and electrically insulated from the pole piece; wherein the anode, the gas distributor, and the thermally conductive plate form an annular recess within the assembly with a volume for a gas between the gas distributor and the anode about a periphery of the gas distributor, wherein any gas introduced into the anode assembly from the base assembly travels through the gas duct, the at least one channel, and the annular recess before acceleration of the gas out of an open end of the anode; and wherein interfaces between the anode, the gas distributor, and the thermally conductive plate contain the gas introduced into the anode assembly from the base assembly within a volume bounded by the anode, the gas distributor, and the thermally conductive plate before acceleration of the gas out of the open end of the anode, and wherein upon removing the pole piece from the base assembly, the pole piece, the thermally conductive plate, the gas distributor, and the anode are separable from the ion source as a unitary assembly.
A T cell comprising: a) a chimeric antigen receptor that binds to CD19, wherein the binding of the CAR to the first antigen is capable of activating the T cell, and b) an inhibitory chimeric antigen receptor (iCAR) comprising an antigen-binding domain that binds to PSMA, and at least a portion of a signaling domain of an immunoinhibitory receptor selected from CTLA-4, PD-1, LAG-3, 2B4, and BTLA, wherein the binding of the iCAR PSMA reduces the cytotoxicity of the T cell against cells that are positive for both CD19 and PSMA a) a chimeric antigen receptor that binds to CD19, wherein the binding of the CAR to the first antigen is capable of activating the T cell, and b) an inhibitory chimeric antigen receptor (iCAR) comprising an antigen-binding domain that binds to PSMA, and at least a portion of a signaling domain of an immunoinhibitory receptor selected from CTLA-4, PD-1, LAG-3, 2B4, and BTLA, wherein the binding of the iCAR PSMA reduces the cytotoxicity of the T cell against cells that are positive for both CD19 and PSMA
A network communication device, comprising: a communication circuit configured and arranged to securely communicate within a wired communication network using a rotating code wherein securely communicating comprises conveying data in the wired communication channel and the rotating code is used for coding the data conveyed over the channel; and a processing circuit configured and arranged to enter a sleep mode in which mode the values of the rotating code are unknown by the network communication device, wherein the processing circuit enters the sleep mode by: requesting another network communication device of the network to authorize entering the sleep mode; and entering the sleep mode responsive to an indication verifying that the network communication device and the other network communication device agree on a set of secure parameters that is created pseudo-randomly, the set of secure parameters being stored and useable to code the values of the rotating code, wherein the processing circuit stores the set of secure parameters for awakening and enters the sleep mode; and wherein the processing circuit is further configured and arranged to transition from the sleep mode to an awake mode responsive to receiving a wake-up request via the communication circuit and a current value of the rotating code that is encoded using the set of secure parameters. a communication circuit configured and arranged to securely communicate within a wired communication network using a rotating code wherein securely communicating comprises conveying data in the wired communication channel and the rotating code is used for coding the data conveyed over the channel; and a processing circuit configured and arranged to enter a sleep mode in which mode the values of the rotating code are unknown by the network communication device, wherein the processing circuit enters the sleep mode by: requesting another network communication device of the network to authorize entering the sleep mode; and entering the sleep mode responsive to an indication verifying that the network communication device and the other network communication device agree on a set of secure parameters that is created pseudo-randomly, the set of secure parameters being stored and useable to code the values of the rotating code, requesting another network communication device of the network to authorize entering the sleep mode; and entering the sleep mode responsive to an indication verifying that the network communication device and the other network communication device agree on a set of secure parameters that is created pseudo-randomly, the set of secure parameters being stored and useable to code the values of the rotating code, wherein the processing circuit stores the set of secure parameters for awakening and enters the sleep mode; and wherein the processing circuit is further configured and arranged to transition from the sleep mode to an awake mode responsive to receiving a wake-up request via the communication circuit and a current value of the rotating code that is encoded using the set of secure parameters.
An acid sphingomyelinase for use in a method of treating an acid sphingomyelinase deficiency in a human subject, wherein the method comprises administering ASM: (a) in a regimen for debulking accumulated sphingomyelin substrate comprising: (i) administration of an initial low non-toxic dose of ASM, wherein said initial dose range is from 0.05 mg/kg to 0.275 mg/kg of ASM; (ii) administration of successively higher doses of ASM, and monitoring the subject for one or more adverse side effects after each successive dose as indicated by elevated total bilirubin concentration, elevated plasma ceramide concentration, elevated plasma C-reactive protein concentration, or an adverse event that has a causal relationship with treatment, wherein said successively higher dose is 0.1 to 1.0 mg/kg higher than the previous dose or 0.1 to 0.5 mg/kg higher than the previous dose; and (b) in a maintenance regimen comprising administration of a dose equal to or less than the highest dose tolerated by the subject as the maintenance dose for the subject, wherein said highest dose tolerated by the human subject is 1 mg/kg to 3 mg/kg. (a) in a regimen for debulking accumulated sphingomyelin substrate comprising: (i) administration of an initial low non-toxic dose of ASM, wherein said initial dose range is from 0.05 mg/kg to 0.275 mg/kg of ASM; (ii) administration of successively higher doses of ASM, and monitoring the subject for one or more adverse side effects after each successive dose as indicated by elevated total bilirubin concentration, elevated plasma ceramide concentration, elevated plasma C-reactive protein concentration, or an adverse event that has a causal relationship with treatment, wherein said successively higher dose is 0.1 to 1.0 mg/kg higher than the previous dose or 0.1 to 0.5 mg/kg higher than the previous dose; and (i) administration of an initial low non-toxic dose of ASM, wherein said initial dose range is from 0.05 mg/kg to 0.275 mg/kg of ASM; (ii) administration of successively higher doses of ASM, and monitoring the subject for one or more adverse side effects after each successive dose as indicated by elevated total bilirubin concentration, elevated plasma ceramide concentration, elevated plasma C-reactive protein concentration, or an adverse event that has a causal relationship with treatment, wherein said successively higher dose is 0.1 to 1.0 mg/kg higher than the previous dose or 0.1 to 0.5 mg/kg higher than the previous dose; and (b) in a maintenance regimen comprising administration of a dose equal to or less than the highest dose tolerated by the subject as the maintenance dose for the subject, wherein said highest dose tolerated by the human subject is 1 mg/kg to 3 mg/kg.
Double-flow axial turbomachine comprising: an axial compressor (42, 44), the compressor being traversed by a flow referred to as primary of the turbomachine; a wall surrounding the compressor (42, 44) and delineating the internal surface of a flow referred to as secondary of the turbomachine; a passage adapted to generate a discharge flow rate controlled from the primary flow in the compressor toward the secondary flow, the passage opening out into the wall delineating the internal surface of the secondary flow; an oil lubrication and/or cooling circuit for elements of the turbomachine; a heat exchanger adapted to cool the oil of the lubrication circuit and arranged at least partially directly in the discharge flow rate of the primary flow; characterized in that the heat exchanger is arranged in the secondary flow directly downstream of the junction of the passage of the discharge flow rate with the wall delineating the internal surface of the secondary flow. an axial compressor (42, 44), the compressor being traversed by a flow referred to as primary of the turbomachine; a wall surrounding the compressor (42, 44) and delineating the internal surface of a flow referred to as secondary of the turbomachine; a passage adapted to generate a discharge flow rate controlled from the primary flow in the compressor toward the secondary flow, the passage opening out into the wall delineating the internal surface of the secondary flow; an oil lubrication and/or cooling circuit for elements of the turbomachine; a heat exchanger adapted to cool the oil of the lubrication circuit and arranged at least partially directly in the discharge flow rate of the primary flow; characterized in that the heat exchanger is arranged in the secondary flow directly downstream of the junction of the passage of the discharge flow rate with the wall delineating the internal surface of the secondary flow.
Hair removal device having a housing which accommodates a drive motor for at least one first shaving system designed as a trimmer, wherein the trimmer has at least two shaving parts (7, 8) having rows of teeth that are each drivable relative to each other, and is always connected to the drive motor; and having at least one additional, second shaving system which has at least one sharp-edged shaver blade; wherein the second shaving system is arranged on a carrier element guided in a movable manner on the housing, characterized in that the carrier element is guided in a displaceable manner on the housing and can be set into at least two different positions via a corresponding switching movement by the user.
A method of blood fractionation comprising: a) centrifuging whole blood in a first syringe having a top coupling element and a bottom coupling element, wherein the whole blood fractionates into a platelet poor plasma layer, a buffy layer, and an erythrocyte layer within the syringe; b) removing at least a portion of the platelet poor plasma layer from the top coupling element of the first syringe; c) attaching a bottom coupling element of a second syringe or second container to the top coupling element of the first syringe; d) drawing any of the platelet poor plasma layer, the buffy layer, and optionally part of the erythrocyte layer into the second syringe or second container; and e) centrifuging the second syringe or second container wherein the any of the platelet poor plasma layer, the buffy layer, and the erythrocyte layer fractionates into a platelet rich plasma layer and an erythrocyte layer. a) centrifuging whole blood in a first syringe having a top coupling element and a bottom coupling element, wherein the whole blood fractionates into a platelet poor plasma layer, a buffy layer, and an erythrocyte layer within the syringe; b) removing at least a portion of the platelet poor plasma layer from the top coupling element of the first syringe; c) attaching a bottom coupling element of a second syringe or second container to the top coupling element of the first syringe; d) drawing any of the platelet poor plasma layer, the buffy layer, and optionally part of the erythrocyte layer into the second syringe or second container; and e) centrifuging the second syringe or second container wherein the any of the platelet poor plasma layer, the buffy layer, and the erythrocyte layer fractionates into a platelet rich plasma layer and an erythrocyte layer.
A burner such as a concentrate burner or a matte burner for feeding reaction gas and fine solids into a reaction shaft of a suspension smelting furnace, wherein the burner comprises an annular fine solids discharge channel that is radially limited at the outside by a first annular wall and that is radially limited at the inside by a second annular wall, wherein the first annular wall being an inner wall of a reaction gas feeding means that surrounds the annular fine solids discharge channel, wherein the second annular wall being formed by an outer wall of a fine solids dispersion device in the annular fine solids discharge channel, and wherein the annular fine solids discharge channel is configured to receive fine solids from a fine solids feeding arrangement and to create an annular flow of fine solids in the annular fine solids discharge channel, characterized by the annular fine solids discharge channel being provided with spreading means configured to be hit by the annular flow of fine solids and configured to even out particle distribution in the annular flow of fine solids, by the spreading means being attached to a separate supporting structure arranged in the annular fine solids discharge channel, by the spreading means being unattached to the first annular wall and unattached to the second annular wall, and by the spreading means having a first free end that is situated at a distance from the first annular wall and a second free end that is situated at a distance from the second annular wall.
A process for preparing a stabilized bioadhesive hot-melt extruded composition comprising an alkaline labile drug, an alkaline matrix-forming polymer and an acidic component, the process comprising the steps of: a) wet or dry granulating at least one water swellable or water soluble alkaline thermoplastic polymer; an antioxidant; at least one bioadhesive polymer; at least one acidic component; and optionally one or more hydrophobic polymers, one or more hydrophilic polymers, one or more other excipients, or a combination thereof to form an excipient mixture having a solution pH of 7 or less; b) mixing the excipient mixture with an alkaline labile drug to form a bioadhesive thermoplastic hydrophilic composition; and c) hot-melt extruding the hydrophilic composition to form the bioadhesive hot-melt extruded composition. a) wet or dry granulating at least one water swellable or water soluble alkaline thermoplastic polymer; an antioxidant; at least one bioadhesive polymer; at least one acidic component; and optionally one or more hydrophobic polymers, one or more hydrophilic polymers, one or more other excipients, or a combination thereof to form an excipient mixture having a solution pH of 7 or less; b) mixing the excipient mixture with an alkaline labile drug to form a bioadhesive thermoplastic hydrophilic composition; and c) hot-melt extruding the hydrophilic composition to form the bioadhesive hot-melt extruded composition.
A steering system of a saddle-ride type vehicle, comprising: a front fork that includes a steering shaft at the upper end and supports a front wheel at the lower end; a steering arm that is attached to the steering shaft; a steering force transmit member that is turnably supported by a steering stem that is arranged in a body frame; and a steering system link that joins the steering arm and the steering force transmit member, wherein the steering system link joins the steering arm and the steering force transmit member that is disposed rearward of the steering arm, characterised by that the steering system link is provided with a steering force detection sensor that detects a steering force transmitted to the steering shaft. a front fork that includes a steering shaft at the upper end and supports a front wheel at the lower end; a steering arm that is attached to the steering shaft; a steering force transmit member that is turnably supported by a steering stem that is arranged in a body frame; and a steering system link that joins the steering arm and the steering force transmit member, wherein the steering system link joins the steering arm and the steering force transmit member that is disposed rearward of the steering arm, characterised by that the steering system link is provided with a steering force detection sensor that detects a steering force transmitted to the steering shaft.
A microelectromechanical systems, MEMS, device comprising: a substrate (307, 407, 507, 907); a proof mass (305, 405, 505, 805, 905, 1205) positioned in space above a surface of the substrate, wherein the proof mass is configured to move relative to the substrate; a flexible travel stop structure (345, 445, 945, 1245) formed within the proof mass, wherein the flexible travel stop structure comprises a contact lever (470, 570, 970, 1270) connected to the proof mass via flexible elements (315, 415, 515, 565, 815, 915, 965, 1265); and a bumper (575, 975, 1275) formed on the surface of the substrate, wherein the contact lever (470, 570, 970, 1270) is aligned to make contact with the bumper (575, 975, 1275) when the proof mass moves toward the substrate; wherein a lower surface of the contact lever (470, 570, 970, 1270) is co-planar with a lower surface of the proof mass (305, 405, 505, 805, 905, 1205), prior to contact with the bumper (575, 975, 1275). a substrate (307, 407, 507, 907); a proof mass (305, 405, 505, 805, 905, 1205) positioned in space above a surface of the substrate, wherein the proof mass is configured to move relative to the substrate; a flexible travel stop structure (345, 445, 945, 1245) formed within the proof mass, wherein the flexible travel stop structure comprises a contact lever (470, 570, 970, 1270) connected to the proof mass via flexible elements (315, 415, 515, 565, 815, 915, 965, 1265); and a bumper (575, 975, 1275) formed on the surface of the substrate, wherein the contact lever (470, 570, 970, 1270) is aligned to make contact with the bumper (575, 975, 1275) when the proof mass moves toward the substrate; wherein a lower surface of the contact lever (470, 570, 970, 1270) is co-planar with a lower surface of the proof mass (305, 405, 505, 805, 905, 1205), prior to contact with the bumper (575, 975, 1275).
Chain link for forming a circular chain made up of a plurality of chain links for an apparatus for storing and providing at least one suspension product, the chain link thereby comprising: a swivelling bearing part with a recess and a bearing axis arranged spaced away from the swivelling bearing part in the direction of the longitudinal extension of the chain link by means of two parallel flange pieces with an axis perpendicular to the longitudinal extension, wherein the swivelling bearing part is C-shaped and designed as an open eyelet with an insertion mouth to hold the bearing axis of a successive chain link and wherein the insertion mouth is designed to lead into the recess, thereby completely extending along the recess in the transverse direction, characterized in that the chain link comprises a suspension hook to suspend a suspension product, that the chain link is designed as a single piece, and that the swivelling bearing piece passes into the suspension hook as a single piece. a swivelling bearing part with a recess and a bearing axis arranged spaced away from the swivelling bearing part in the direction of the longitudinal extension of the chain link by means of two parallel flange pieces with an axis perpendicular to the longitudinal extension, wherein the swivelling bearing part is C-shaped and designed as an open eyelet with an insertion mouth to hold the bearing axis of a successive chain link and wherein the insertion mouth is designed to lead into the recess, thereby completely extending along the recess in the transverse direction, characterized in that the chain link comprises a suspension hook to suspend a suspension product, that the chain link is designed as a single piece, and that the swivelling bearing piece passes into the suspension hook as a single piece.
A high gamma prime nickel-based superalloy, comprising by wt. %: - Chromium from 9.0 to 10.5 %, - Cobalt from about 16 to 22 %, - Molybdenum from 1.0 to 1.4 %, - Tungsten from 5.0 to 5.8 %, - Tantalum from 2.0 to 6.0 %, - Niobium from 1.0 to 4.0 %, - Tantalum plus Niobium from 3.0 to 7.0 %, - Aluminum from 3.0 to 6.5 %, - Hafnium from 0.2 to 1.5 %, - Germanium from 0 to 1.0 %, - Yttrium from 0 to 0.2 %, - Silicon from 0 to 1.0 %, - Boron from 0 to 0.015 %, - Carbon from 0.01 to 0.2%, - Rhenium from 1.5 to 3.5 %, and - Nickel with impurities to balance. - Chromium from 9.0 to 10.5 %, - Cobalt from about 16 to 22 %, - Molybdenum from 1.0 to 1.4 %, - Tungsten from 5.0 to 5.8 %, - Tantalum from 2.0 to 6.0 %, - Niobium from 1.0 to 4.0 %, - Tantalum plus Niobium from 3.0 to 7.0 %, - Aluminum from 3.0 to 6.5 %, - Hafnium from 0.2 to 1.5 %, - Germanium from 0 to 1.0 %, - Yttrium from 0 to 0.2 %, - Silicon from 0 to 1.0 %, - Boron from 0 to 0.015 %, - Carbon from 0.01 to 0.2%, - Rhenium from 1.5 to 3.5 %, and - Nickel with impurities to balance.