A system suitable for a ductless fume hood and a chemical database, said system comprising: a ductless fume hood comprising: a hood enclosure; a control panel; a processor operatively coupled to the control panel and configured to execute computer program instructions for an operating system configured to operate the ductless fume hood; an exhaust stack; and wherein a motor operatively coupled to the ductless fume hood is configured to draw an effluent stream of contaminated air through the hood enclosure and at least one chemical removal filter for egress at the exhaust stack; a chemical database which is configured to be accessed by the operating system, characterized in that the ductless fume hood is also provided of two or more detectors comprising a photo-ionization detector sensor, PID, and at least one of a metal oxide detector, MOX, or an acid array sensor for monitoring for the presence of at least one contaminant species in the ductless fume hood; in that the chemical database is pre-programed with chemicals approved for use in the ductless fume hood with filters; in that the operating system is configured to confirm, in response to a user selection of one chemical from the chemical database, that the at least one chemical removal filter is capable of removing the chemical selected from the effluent stream of contaminated air; in that the operating system is configured to select, in response to the chemical selected, the detector that is compatible with the chemical; and in that, in the event that the chemical filter is not compatible with the chemical selected, the operating system will prevent operation of the ductless fume hood using the chemical filter or wherein in the event that the detectors are not compatible with the chemical selected, the operating system will not allow operation of the ductless fume hood using said detectors. a ductless fume hood comprising: a hood enclosure; a control panel; a processor operatively coupled to the control panel and configured to execute computer program instructions for an operating system configured to operate the ductless fume hood; an exhaust stack; and wherein a motor operatively coupled to the ductless fume hood is configured to draw an effluent stream of contaminated air through the hood enclosure and at least one chemical removal filter for egress at the exhaust stack; a hood enclosure; a control panel; a processor operatively coupled to the control panel and configured to execute computer program instructions for an operating system configured to operate the ductless fume hood; an exhaust stack; and wherein a motor operatively coupled to the ductless fume hood is configured to draw an effluent stream of contaminated air through the hood enclosure and at least one chemical removal filter for egress at the exhaust stack; a chemical database which is configured to be accessed by the operating system, characterized in that the ductless fume hood is also provided of two or more detectors comprising a photo-ionization detector sensor, PID, and at least one of a metal oxide detector, MOX, or an acid array sensor for monitoring for the presence of at least one contaminant species in the ductless fume hood; in that the chemical database is pre-programed with chemicals approved for use in the ductless fume hood with filters; in that the operating system is configured to confirm, in response to a user selection of one chemical from the chemical database, that the at least one chemical removal filter is capable of removing the chemical selected from the effluent stream of contaminated air; in that the operating system is configured to select, in response to the chemical selected, the detector that is compatible with the chemical; and in that, in the event that the chemical filter is not compatible with the chemical selected, the operating system will prevent operation of the ductless fume hood using the chemical filter or wherein in the event that the detectors are not compatible with the chemical selected, the operating system will not allow operation of the ductless fume hood using said detectors.