mhurhangee/ep-ind-claims huggingface dataset:
A compound of the following formula or a pharmaceutically acceptable salt thereof: including any stereochemically isomeric form thereof, wherein: n is 0 or 1; R 1 is C1-C4 alkyl (optionally substituted with hydroxyl or halogen), preferably methyl, fluoromethyl, difluoromethyl, trifluoromethyl; each of R 2, R 3, and R 4 is independently hydrogen, halogen, or the R 2 and R 4 groups, taken together, form a six membered heterocyclic ring containing a nitrogen atom, provided that at least one of R 2, R 3, and R 4 is not hydrogen; each of R 5 and R 6 is hydrogen or halogen provided that at least one of R 5 and R 6 is halogen. n is 0 or 1; R 1 is C1-C4 alkyl (optionally substituted with hydroxyl or halogen), preferably methyl, fluoromethyl, difluoromethyl, trifluoromethyl; each of R 2, R 3, and R 4 is independently hydrogen, halogen, or the R 2 and R 4 groups, taken together, form a six membered heterocyclic ring containing a nitrogen atom, provided that at least one of R 2, R 3, and R 4 is not hydrogen; each of R 5 and R 6 is hydrogen or halogen provided that at least one of R 5 and R 6 is halogen.
An acetabular shell comprising: a cup-shaped body having an interior surface and an exterior surface, the cup-shaped body comprising a first porous structure; a plurality of holes (52A - 52L) extending from the interior surface to the exterior surface so as to be able to permit fasteners to extend through the cup-shaped body; a plug (54A - 54D) disposed in each of the plurality of holes to prevent a fastener from extending through each of the plurality of holes, characterised in that each of the plugs (54A - 54D) comprises a second porous structure the first and second porous structures comprised of a first material; and a plurality of crosspieces connecting each plug to one of the plurality of holes, wherein each crosspiece is comprised of a second material contiguously defining the cup-shaped body and the plugs, wherein the second material comprises a layer covering the first and second porous structures and defining the plurality of crosspieces and wherein each of the plurality of crosspieces comprises a ligament. a cup-shaped body having an interior surface and an exterior surface, the cup-shaped body comprising a first porous structure; a plurality of holes (52A - 52L) extending from the interior surface to the exterior surface so as to be able to permit fasteners to extend through the cup-shaped body; a plug (54A - 54D) disposed in each of the plurality of holes to prevent a fastener from extending through each of the plurality of holes, characterised in that each of the plugs (54A - 54D) comprises a second porous structure the first and second porous structures comprised of a first material; and a plurality of crosspieces connecting each plug to one of the plurality of holes, wherein each crosspiece is comprised of a second material contiguously defining the cup-shaped body and the plugs, wherein the second material comprises a layer covering the first and second porous structures and defining the plurality of crosspieces and wherein each of the plurality of crosspieces comprises a ligament.
An electrode implantation tool comprising: a catheter guide and introducer support comprising: a first alignment member; a second alignment member; and a body member attached to the first and second alignment members, wherein the body member fixes the relative orientations of the first and second alignment members; a catheter guide supported by the first alignment member, the catheter guide comprising an elongate body having a distal end and a channel that is aligned with a longitudinal axis; and an introducer comprising a sheath supported by the second alignment member, the sheath defining a longitudinal axis; wherein the first and second alignment members orient the longitudinal axis of the sheath at a predetermined angle to the longitudinal axis of the catheter guide characterised in that the sheath has a lumen through which an electrode lead may be passed. a catheter guide and introducer support comprising: a first alignment member; a second alignment member; and a body member attached to the first and second alignment members, wherein the body member fixes the relative orientations of the first and second alignment members; a first alignment member; a second alignment member; and a body member attached to the first and second alignment members, wherein the body member fixes the relative orientations of the first and second alignment members; a catheter guide supported by the first alignment member, the catheter guide comprising an elongate body having a distal end and a channel that is aligned with a longitudinal axis; and an introducer comprising a sheath supported by the second alignment member, the sheath defining a longitudinal axis; wherein the first and second alignment members orient the longitudinal axis of the sheath at a predetermined angle to the longitudinal axis of the catheter guide characterised in that the sheath has a lumen through which an electrode lead may be passed.
Electrical domestic appliance with a cold reservoir, in particular electrical refrigerator, including a cabinet body with freezer compartment, a closable door of the freezer compartment and a cold reservoir, which is arranged on the interior of the door, wherein the interior of the door has a projection oriented towards the freezer compartment and an opening for conveying chunks of ice out of the freezer compartment is located on this projection, characterised in that a depression is formed on the projection under this opening, and this cold reservoir is arranged in this depression.
Device for the estimation in real time of a land vehicle adhesion, comprising electronic computing means installed in a vehicle, configured to acquire the signals detected by: - at least a triaxial accelerometer integral to the vehicle; - a steering angle meter of said vehicle; - a plurality of encoders, configured to measure the angular velocity of each wheel of said vehicle; - a plurality of temperature sensors, configured to acquire the outer temperature of each tyre; - a plurality of pressure sensors configured to acquire the inner air pressure of each tyre, characterized in that computer programs are loaded on said electronic computing means, and are configured: to estimate the inner temperature of each tyre as a function of the outer temperature and inner air pressure; to calculate the angular velocity (w) and the components of the velocity of translation (V x, V y) for each tyre; to determine the slip ratio (sr) and the slip angle (sa) for each tyre, as a function of the velocities of translation (Vx, Vy), of the angular velocity (w) and of the tyre rolling height; to calculate the longitudinal, lateral and vertical components (Fx, Fy, Fz) of the forces exchanged by each tyre with the ground; to estimate the values of the instantaneous coefficient of friction from the equations of dynamic balance on each tyre: μ instantaneous, estimation = F x 2 + F y 2 F z to compare the values of the coefficient of friction calculated at point with the estimation of the maximum coefficient of friction estimated in the same vertical load (Fz), kinematic and thermodynamic conditions: μ potential = f F z sr sa T tyre p tyre w tyre - at least a triaxial accelerometer integral to the vehicle; - a steering angle meter of said vehicle; - a plurality of encoders, configured to measure the angular velocity of each wheel of said vehicle; - a plurality of temperature sensors, configured to acquire the outer temperature of each tyre; - a plurality of pressure sensors configured to acquire the inner air pressure of each tyre, to estimate the inner temperature of each tyre as a function of the outer temperature and inner air pressure; to calculate the angular velocity (w) and the components of the velocity of translation (V x, V y) for each tyre; to determine the slip ratio (sr) and the slip angle (sa) for each tyre, as a function of the velocities of translation (Vx, Vy), of the angular velocity (w) and of the tyre rolling height; to calculate the longitudinal, lateral and vertical components (Fx, Fy, Fz) of the forces exchanged by each tyre with the ground; to estimate the values of the instantaneous coefficient of friction from the equations of dynamic balance on each tyre: μ instantaneous, estimation = F x 2 + F y 2 F z to compare the values of the coefficient of friction calculated at point with the estimation of the maximum coefficient of friction estimated in the same vertical load (Fz), kinematic and thermodynamic conditions: μ potential = f F z sr sa T tyre p tyre w tyre
A method of handling time information in a communications system comprising: receiving a message at a proxy entity (110, 112, 114) acting as a proxy with respect to a core network, the proxy entity being one of a plurality of proxy entities of the communications system being located in respective visited networks (102, 104, 106), the visited networks having respective time differences with respect to a core network time; using by the proxy entity time information associated with the message to determine a time zone offset between a local time and the core network time; providing the time zone offset to a network element in the core network; and using the time zone offset to generate a time stamp in the core network adjusted to correspond to the local time. receiving a message at a proxy entity (110, 112, 114) acting as a proxy with respect to a core network, the proxy entity being one of a plurality of proxy entities of the communications system being located in respective visited networks (102, 104, 106), the visited networks having respective time differences with respect to a core network time; using by the proxy entity time information associated with the message to determine a time zone offset between a local time and the core network time; providing the time zone offset to a network element in the core network; and using the time zone offset to generate a time stamp in the core network adjusted to correspond to the local time.
An apparatus for dispensing liquid into an eye, the apparatus comprising: an emitter for emitting a light beam towards an eye; a detector for detecting light reflected off of an open eye while the detector is positioned proximate to the eye; an automated dispenser for dispensing a liquid towards the eye; a processor in logical communication with the detector, the processor functional to coordinate dispensing of the liquid towards the eye based upon a detection of light reflected off of an eye; wherein the apparatus comprises a line of sight comprising a tubular cutout in a body of the apparatus. an emitter for emitting a light beam towards an eye; a detector for detecting light reflected off of an open eye while the detector is positioned proximate to the eye; an automated dispenser for dispensing a liquid towards the eye; a processor in logical communication with the detector, the processor functional to coordinate dispensing of the liquid towards the eye based upon a detection of light reflected off of an eye; wherein the apparatus comprises a line of sight comprising a tubular cutout in a body of the apparatus.
Safety catheter needle comprising a cannula removably inserted in a catheter, said cannula being associated with a cannula holder, said catheter being associated with a catheter holder which is in turn removably attached to said cannula holder, the cannula having one proximal extremity attached to the cannula holder and a distal extremity capable of sliding in catheter at the time when the cannula is separated from said catheter, close to the distal extremities of said cannula having a deformed part, being provided with a protection device associated with the catheter holder capable of accommodating said distal extremity of the cannula after it has been completely detached from the catheter, said protection device comprising bodies (12, 13) which act together magnetically and are able to immobilise said distal extremity of the cannula within said protection device, said bodies being a first body and a second body, characterised in that both bodies are at least partly magnetised, the first body contains the second body, the second body having a transverse longitudinal axis with respect to said first body and being capable of rotating within said first body around such longitudinal axis, said second body having a through hole with an axis which is substantially coaxial with a longitudinal axis of a cavity in the first body when the distal extremity of said cannula is outside said protection device, said second body being rotated through magnetic repulsion and/or attraction between said first body and about its own longitudinal axis when the distal extremity of said cannula is within the protection device but outside said through hole, the rotated position of said second body around said longitudinal axis and within the aforesaid first body blocking emergence of said distal extremity of the cannula from said protection device.
A method of making a tissue valve, comprising: attaching a valve assembly within a support configured to fit within a blood vessel; and lyophilizing the valve assembly after the valve assembly has been attached to the support. attaching a valve assembly within a support configured to fit within a blood vessel; and lyophilizing the valve assembly after the valve assembly has been attached to the support.
A computer-implemented method for monitoring usage of a cutting element of a hair cutting device, the method comprising: receiving pressure data indicative of a pressure applied by a cutting element of a hair cutting device on a surface at intervals during a cutting event; storing the received pressure data in a storage device; estimating, based on pressure data stored in the storage device in relation to the cutting event and on pressure data stored in the storage device in relation to one or more previous cutting events, a level of wear of the cutting element wherein estimating a level of wear of the cutting element comprises: determining, based on a summation or numerical integration of the stored pressure data relating to the cutting event and the stored pressure data relating to the one or more previous cutting events, a total pressure applied by the cutting element to the surface since a defined start point; and estimating the level of wear based on the calculated summed or integrated pressure data.; and providing an indication of the estimated level of wear for presentation to a recipient. receiving pressure data indicative of a pressure applied by a cutting element of a hair cutting device on a surface at intervals during a cutting event; storing the received pressure data in a storage device; estimating, based on pressure data stored in the storage device in relation to the cutting event and on pressure data stored in the storage device in relation to one or more previous cutting events, a level of wear of the cutting element wherein estimating a level of wear of the cutting element comprises: determining, based on a summation or numerical integration of the stored pressure data relating to the cutting event and the stored pressure data relating to the one or more previous cutting events, a total pressure applied by the cutting element to the surface since a defined start point; and estimating the level of wear based on the calculated summed or integrated pressure data.; and providing an indication of the estimated level of wear for presentation to a recipient. determining, based on a summation or numerical integration of the stored pressure data relating to the cutting event and the stored pressure data relating to the one or more previous cutting events, a total pressure applied by the cutting element to the surface since a defined start point; and estimating the level of wear based on the calculated summed or integrated pressure data.; and providing an indication of the estimated level of wear for presentation to a recipient.
An irrigation system for irrigating a field divided into zones, wherein the system comprises a plurality of distinct drip line segments, wherein at least a first drip line segment is configured to irrigate at least a portion of a first zone and at least one other second drip line segment is configured to irrigate at least a portion of a second zone, wherein the first drip line segment is located immediately upstream of the second drip line segment, characterized in that the system is configured to open simultaneously a flow path out of the first drip line segment for flushing liquid, while opening a flow path into the second drip line segment for performing a drip irrigation sequence. wherein the system comprises a plurality of distinct drip line segments, wherein at least a first drip line segment is configured to irrigate at least a portion of a first zone and at least one other second drip line segment is configured to irrigate at least a portion of a second zone, wherein the first drip line segment is located immediately upstream of the second drip line segment, characterized in that the system is configured to open simultaneously a flow path out of the first drip line segment for flushing liquid, while opening a flow path into the second drip line segment for performing a drip irrigation sequence.
A method of operating an ATC Radar, comprising the steps of: receiving In-phase and Quadrature signals; creating first and second complex clutter maps using the I and Q signals; wherein the first map comprises data which is dynamically updated on a per-scan basis and the second map comprises data indicative of a static environment with no targets; subtracting data from the second map from the received I and Q signals to mitigate the effects of static objects in the environment, to yield compensated I and Q data; using the compensated I and Q data for target detection an/or tracking, characterised in that if a return is received from a wind turbine blade, which is substantially higher than other returns from the same transmit burst, then the substantially higher return is either ignored or attenuated to conform to other returns from the same transmit burst. receiving In-phase and Quadrature signals; creating first and second complex clutter maps using the I and Q signals; wherein the first map comprises data which is dynamically updated on a per-scan basis and the second map comprises data indicative of a static environment with no targets; subtracting data from the second map from the received I and Q signals to mitigate the effects of static objects in the environment, to yield compensated I and Q data; using the compensated I and Q data for target detection an/or tracking, characterised in that if a return is received from a wind turbine blade, which is substantially higher than other returns from the same transmit burst, then the substantially higher return is either ignored or attenuated to conform to other returns from the same transmit burst.
A vehicle control device for controlling a traveling operation of a vehicle, the vehicle control device comprising a processor that calculates a control parameter to control the traveling operation of the vehicle, wherein the processor executes: a first travel control mode in which the vehicle is caused to travel in a first traveling mode; a second travel control mode in which the vehicle is caused to travel in a second traveling mode in which a function is degenerated as compared to the first traveling mode; and a third travel control mode in which the vehicle is caused to travel in a third traveling mode which is a transitional traveling mode during transition from the second traveling mode to the first traveling mode, the processor calculates a first control parameter to control the traveling operation of the vehicle in the first traveling mode during execution of the third travel control mode, determines whether or not a value of the first control parameter is normal, calculates a second control parameter to control the traveling operation of the vehicle in the second traveling mode, and controls the traveling operation of the vehicle using a value of the second control parameter; the processor transitions from the third travel control mode to the first travel control mode when it is determined that the first control parameter is normal in the third travel control mode, and returns to the second travel control mode from the third travel control mode when it is determined that the first control parameter is not normal, and the processor measures a time during which a difference between the first control parameter and the second control parameter is equal to or less than a predetermined threshold value before returning to the second travel control mode from the third travel control mode, and transitions from the third travel control mode to the first travel control mode at a point in time at which the time during which the difference is equal to or less than the predetermined threshold value reaches a predetermined time or longer.
Use of beta-sitosterol-beta-D-glycoside-induced neurodegeneration in a non-human animal model for examining neurodegeneration, characterised in that said non-human animal model is a mouse having neurodegeneration caused by administration of beta-sitosterol-beta-D-glycoside in an amount sufficient to cause the neurodegeneration in said mouse.
A method of preparing wholly aromatic liquid crystalline polyester resin, the method comprising: synthesizing a wholly aromatic liquid crystalline polyester prepolymer by condensation polymerization of at least two different monomers; and reducing an internal pressure of a reaction vessel containing the prepolymer to remove a byproduct and unreacted monomers and lead to condensation polymerization of the prepolymer, thereby synthesizing the wholly aromatic liquid crystalline polyester resin, wherein an internal pressure reduction rate of the reaction vessel is in a range of about 17∼20 torr/min, wherein the reaction vessel is equipped with an agitator, and a time for which the reduced internal pressure of the reaction vessel is maintained is controlled based on a torque value of the agitator, wherein the reduced internal pressure state of the reaction vessel is released when the torque value of the agitator reaches about 5∼6N·m. synthesizing a wholly aromatic liquid crystalline polyester prepolymer by condensation polymerization of at least two different monomers; and reducing an internal pressure of a reaction vessel containing the prepolymer to remove a byproduct and unreacted monomers and lead to condensation polymerization of the prepolymer, thereby synthesizing the wholly aromatic liquid crystalline polyester resin, wherein an internal pressure reduction rate of the reaction vessel is in a range of about 17∼20 torr/min, wherein the reaction vessel is equipped with an agitator, and a time for which the reduced internal pressure of the reaction vessel is maintained is controlled based on a torque value of the agitator, wherein the reduced internal pressure state of the reaction vessel is released when the torque value of the agitator reaches about 5∼6N·m.
A pharmaceutical composition comprising an oritavancin drug substance preparation and one or more pharmaceutically acceptable excipients, wherein the oritavancin drug substance preparation has a maximum impurity level of not more than 3.0% by peak area of impurity 1 (oritavancin factor A) and impurity 7 (oritavancin factor C), wherein oritavancin factor A has the structure and oritavancin factor C has the structure and wherein the purity level of the oritavancin drug substance preparation is measured by HPLC.