A compound having the structure of Formula I-R or I-S or a pharmaceutically acceptable salt, hydrate or solvate thereof: wherein X is -NR'R" or -OR'''; Y is -CN, -Cl, -CF 3, I, -COOH, or -COOR 1; R' is H, C 1-4 alkyl, n-hydroxy C 1-4 alkyl, -SO 2 -R 1, or -CO-R 1; R" is H, -SO 2 -R 3, C 1-4 alkyl optionally substituted with 1 or more R 2, or a ring moiety optionally substituted with R 4 wherein such ring moiety is piperidinyl, cyclohexyl, morpholinyl, thiazolyl, pyrazolyl, pyrrolidinyl, imidazolyl, or phenyl; or R' and R" taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally singly or multiply substituted with substituents independently selected from the group consisting of -OH, oxo, - NH 2, n-hydroxy-C 1-4 alkyl, -COOH, -(CH 2) m -COOH, -(CH 2) m -COOR 1, -N(R 1 R 1), and-(CH 2) m -CO-N(R 5 R 5); R"' is H, C 1-4 alkyl, or -CO-R 1; each R 1 is independently C 1-4 alkyl or H; each R 2 is independently H, halo, OH, oxo, =NH, NH 2, -COOH, F, -NHR 1, -N(R 5 R 5),-SO 2 -R 1, -SO 2 -N(R 5 R 5), -N(R 1)-SO 2 -R 1, -COOR 1, -OCO-R 1, -CO-N(R 5 R 5), -N(R 1)-COR 1, C 1-3 alkyl, C 1-3 alkoxy, and a ring moiety optionally substituted with R 4 wherein such ring moiety is piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrazolyl, imidazolyl, benzimidazolyl, azetidinyl, cyclobutinyl, or phenyl; each R 3 is independently R 2, C 1-4 alkyl, C 3-6 cycloalkyl, or C 1-4 alkyl optionally substituted with 1 or more R 2; each R 4 is independently halo, OH, -NH 2, -NHR 1, -N(R 1 R 1), -COOH, -COOR 1, -NHCO-R 1; each R 5 is independently C 1-4 alkyl or H, or two R 5 taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally substituted with -OH, -NH 2, -N(R 1 R 1), n-hydroxy C 1-4 alkyl, -(CH 2) m -COOH,-(CH 2) m -COOR 1; and each m is independently 0, 1, 2, or 3. X is -NR'R" or -OR'''; Y is -CN, -Cl, -CF 3, I, -COOH, or -COOR 1; R' is H, C 1-4 alkyl, n-hydroxy C 1-4 alkyl, -SO 2 -R 1, or -CO-R 1; R" is H, -SO 2 -R 3, C 1-4 alkyl optionally substituted with 1 or more R 2, or a ring moiety optionally substituted with R 4 wherein such ring moiety is piperidinyl, cyclohexyl, morpholinyl, thiazolyl, pyrazolyl, pyrrolidinyl, imidazolyl, or phenyl; or R' and R" taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally singly or multiply substituted with substituents independently selected from the group consisting of -OH, oxo, - NH 2, n-hydroxy-C 1-4 alkyl, -COOH, -(CH 2) m -COOH, -(CH 2) m -COOR 1, -N(R 1 R 1), and-(CH 2) m -CO-N(R 5 R 5); R"' is H, C 1-4 alkyl, or -CO-R 1; each R 1 is independently C 1-4 alkyl or H; each R 2 is independently H, halo, OH, oxo, =NH, NH 2, -COOH, F, -NHR 1, -N(R 5 R 5),-SO 2 -R 1, -SO 2 -N(R 5 R 5), -N(R 1)-SO 2 -R 1, -COOR 1, -OCO-R 1, -CO-N(R 5 R 5), -N(R 1)-COR 1, C 1-3 alkyl, C 1-3 alkoxy, and a ring moiety optionally substituted with R 4 wherein such ring moiety is piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrazolyl, imidazolyl, benzimidazolyl, azetidinyl, cyclobutinyl, or phenyl; each R 3 is independently R 2, C 1-4 alkyl, C 3-6 cycloalkyl, or C 1-4 alkyl optionally substituted with 1 or more R 2; each R 4 is independently halo, OH, -NH 2, -NHR 1, -N(R 1 R 1), -COOH, -COOR 1, -NHCO-R 1; each R 5 is independently C 1-4 alkyl or H, or two R 5 taken together with the nitrogen atom to which they are bound form a 4, 5, or 6 membered saturated heterocyclic ring containing 0 or 1 additional heteroatoms where such additional heteroatom is O or N wherein such heterocycle is optionally substituted with -OH, -NH 2, -N(R 1 R 1), n-hydroxy C 1-4 alkyl, -(CH 2) m -COOH,-(CH 2) m -COOR 1; and each m is independently 0, 1, 2, or 3.