A compound of Formula III: or a pharmaceutically acceptable salt, thereof; wherein: R 1 is H or CH 3; R 2 is OH; R 3 is H; R 4 is OH; R 5 is H; R 6 is CN; R 7 is H, or each Y or Y 1 is, independently, O, S, NR, + N, N, + N, or N-NR 2; W 1 and W 2, when taken together, are -Y 3 (C(R y) 2) 3 Y 3 -; or one of W 1 or W 2 together with either R 3 or R 4 is -Y 3 - and the other of W 1 or W 2 is Formula Ia; or W 1 and W 2 are each, independently, a group of the Formula Ia: wherein: each Y 2 is independently a bond, O, CR 2, NR, + N, N, + N, N-NR 2, S, S-S, S, or S 2; each Y 3 is independently O, S, or NR; M2 is 0, 1 or 2; each R x is independently R y or the formula: wherein: each M1 a, M1c, and M1d is independently 0 or 1; M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; each R y is independently H, F, Cl, Br, I, OH, R, -C(=Y 1)R, -C(=Y 1)OR, -C(=Y 1)N 2, -N 2, - + N 3, -SR, -S R, -S 2 R, -S, -S 2, -OC(=Y 1)R, -OC(=Y 1)OR, -OC(=Y 1)(N 2), -SC(=Y 1)R, -SC(=Y 1)OR, -SC(=Y 1)(N 2), -N C(=Y 1)R, -N C(=Y 1)OR, -N C(=Y 1)N 2, -SO 2 NR 2, -CN, -N 3, -NO 2, -OR, or W 3; or when taken together, two R y on the same carbon atom form a carbocyclic ring of 3 to 7 carbon atoms; each R is independently H, (C 1 -C 8) alkyl, (C 1 -C 8) substituted alkyl, (C 2 -C 8)alkenyl, (C 1 -C 8) substituted alkenyl, (C 1 -C 8) alkynyl, (C 1 -C 8) substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heterocyclyl, C 2 -C 20 substituted heterocyclyl, arylalkyl or substituted arylalkyl; W 3 is W 4 or W 5; W 4 is R, -C(Y 1)R y, -C(Y 1)W 5, -SO 2 R y, or -SO 2 W 5; and W 5 is a carbocycle or a heterocycle wherein W 5 is independently substituted with 0 to 3 R y groups; R 8 is NR 11 R 12; each R 9 or R 10 is independently H; each R 11 or R 12 is independently H. R 1 is H or CH 3; R 2 is OH; R 3 is H; R 4 is OH; R 5 is H; R 6 is CN; R 7 is H, or each Y or Y 1 is, independently, O, S, NR, + N, N, + N, or N-NR 2; W 1 and W 2, when taken together, are -Y 3 (C(R y) 2) 3 Y 3 -; or one of W 1 or W 2 together with either R 3 or R 4 is -Y 3 - and the other of W 1 or W 2 is Formula Ia; or W 1 and W 2 are each, independently, a group of the Formula Ia: each Y 2 is independently a bond, O, CR 2, NR, + N, N, + N, N-NR 2, S, S-S, S, or S 2; each Y 3 is independently O, S, or NR; M2 is 0, 1 or 2; each R x is independently R y or the formula: each M1 a, M1c, and M1d is independently 0 or 1; M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; each R y is independently H, F, Cl, Br, I, OH, R, -C(=Y 1)R, -C(=Y 1)OR, -C(=Y 1)N 2, -N 2, - + N 3, -SR, -S R, -S 2 R, -S, -S 2, -OC(=Y 1)R, -OC(=Y 1)OR, -OC(=Y 1)(N 2), -SC(=Y 1)R, -SC(=Y 1)OR, -SC(=Y 1)(N 2), -N C(=Y 1)R, -N C(=Y 1)OR, -N C(=Y 1)N 2, -SO 2 NR 2, -CN, -N 3, -NO 2, -OR, or W 3; or when taken together, two R y on the same carbon atom form a carbocyclic ring of 3 to 7 carbon atoms; each R is independently H, (C 1 -C 8) alkyl, (C 1 -C 8) substituted alkyl, (C 2 -C 8)alkenyl, (C 1 -C 8) substituted alkenyl, (C 1 -C 8) alkynyl, (C 1 -C 8) substituted alkynyl, C 6 -C 20 aryl, C 6 -C 20 substituted aryl, C 2 -C 20 heterocyclyl, C 2 -C 20 substituted heterocyclyl, arylalkyl or substituted arylalkyl; W 3 is W 4 or W 5; W 4 is R, -C(Y 1)R y, -C(Y 1)W 5, -SO 2 R y, or -SO 2 W 5; and W 5 is a carbocycle or a heterocycle wherein W 5 is independently substituted with 0 to 3 R y groups; R 8 is NR 11 R 12; each R 9 or R 10 is independently H; each R 11 or R 12 is independently H.