A compound of formula I or a pharmaceutically acceptable salt thereof wherein: U is (CH 2) n, where n = 1, 2 or 3; R 1 is selected from the group consisting of: (C 1 -C 10)alkyl, (C 1 -C 10)alkyl substituted with one or more fluorine, and nitrile; Cy is selected from the group consisting of phenyl, naphthyl, indole, quinoline, isoquinoline, pyridine, and benzimidazolyl,; R 11 and R 12 are independently selected from the group consisting of: H, (C 1 -C 10)alkyl, (C 1 -C 10)perfluoroalkyl, halogen, hydroxy, (C 1 -C 10)alkoxy, amino, (C 1 -C 10)alkylamino, (C 1 -C 10)acylamino, aryl, heteroaryl, aminocarbonyl, carboxyl, and (C 1 -C 10)alkoxycarbonyl; or taken together, R 11 and R 12 may form a 5, 6, or 7-membered carbocycle or heterocycle wherein said carbocycle or heterocycle may be optionally substituted with R 2; R 2 is selected from the group consisting of: halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, carboxy, amino, (C 1 -C 4)alkylamino and di(C 1 -C 4)alkylamino; Y is selected from L and L' are independently a bond or (CR 3 R 4) m where R 3 and R 4 are independently selected from the group consisting of H and (C 1 -C 4)alkyl, and m is 1 or 2; R 10 is chosen from carbocycle and heterocycle, wherein said carbocycle or heterocycle is optionally substituted with R 7 and/or R 8; R 20 is -C(=O)OR 21; R 21 is chosen from H and (C 1 -C 4)alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, hydroxy, (C 1 -C 10) hydrocarbyl, halo(C 1 -C 10)hydrocarbyl, and (C 1 -C 10)alkoxy; R 7 and R 8 are independently selected from the group consisting of: hydroxy, halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, (C 1 -C 4)alkylthio, (C 1 -C 4)alkylcarbonyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, oxo, (C 1 -C 4)alkylsulfonyl, amino, (C 1 -C 4)alkylamino, di(C 1 -C 4)alkylamino, (C 1 -C 4)acylamino, aminocarbonyl, carboxyl, and (C 1 -C 4)alkoxycarbonyl, where each said alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, may be further optionally substituted with hydroxy, oxo, carboxy, carboxy(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, (C 1 -C 4)alkoxycarbonyl, (C 1 -C 4)alkoxycarbonyl(C 1 -C 4)alkyl, amino, (C 1 -C 4)alkylamino, di (C 1 -C 4)alkylamino, amido, (C 1 -C 4)alkylamido, di (C 1 -C 4)alkylamido, halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, aryl, heteroaryl, heterocycloalkyl, or cycloalkyl; or, taken together, R 5 and R 6, or R 7 and R 8 may form a 5, 6, or 7-membered carbocycle or heterocycle, wherein said carbocycle or heterocycle is optionally substituted with R 9; R 9 is selected from the group consisting of: halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, amino, (C 1 -C 4)alkylamino and di(C 1 -C 4)alkylamino. U is (CH 2) n, where n = 1, 2 or 3; R 1 is selected from the group consisting of: (C 1 -C 10)alkyl, (C 1 -C 10)alkyl substituted with one or more fluorine, and nitrile; Cy is selected from the group consisting of phenyl, naphthyl, indole, quinoline, isoquinoline, pyridine, and benzimidazolyl,; R 11 and R 12 are independently selected from the group consisting of: H, (C 1 -C 10)alkyl, (C 1 -C 10)perfluoroalkyl, halogen, hydroxy, (C 1 -C 10)alkoxy, amino, (C 1 -C 10)alkylamino, (C 1 -C 10)acylamino, aryl, heteroaryl, aminocarbonyl, carboxyl, and (C 1 -C 10)alkoxycarbonyl; or taken together, R 11 and R 12 may form a 5, 6, or 7-membered carbocycle or heterocycle wherein said carbocycle or heterocycle may be optionally substituted with R 2; R 2 is selected from the group consisting of: halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, carboxy, amino, (C 1 -C 4)alkylamino and di(C 1 -C 4)alkylamino; Y is selected from L and L' are independently a bond or (CR 3 R 4) m where R 3 and R 4 are independently selected from the group consisting of H and (C 1 -C 4)alkyl, and m is 1 or 2; R 10 is chosen from carbocycle and heterocycle, wherein said carbocycle or heterocycle is optionally substituted with R 7 and/or R 8; R 20 is -C(=O)OR 21; R 21 is chosen from H and (C 1 -C 4)alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, hydroxy, (C 1 -C 10) hydrocarbyl, halo(C 1 -C 10)hydrocarbyl, and (C 1 -C 10)alkoxy; R 7 and R 8 are independently selected from the group consisting of: hydroxy, halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, (C 1 -C 4)alkylthio, (C 1 -C 4)alkylcarbonyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cyano, oxo, (C 1 -C 4)alkylsulfonyl, amino, (C 1 -C 4)alkylamino, di(C 1 -C 4)alkylamino, (C 1 -C 4)acylamino, aminocarbonyl, carboxyl, and (C 1 -C 4)alkoxycarbonyl, where each said alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, may be further optionally substituted with hydroxy, oxo, carboxy, carboxy(C 1 -C 4)alkyl, hydroxy(C 1 -C 4)alkyl, (C 1 -C 4)alkoxy, (C 1 -C 4)alkoxycarbonyl, (C 1 -C 4)alkoxycarbonyl(C 1 -C 4)alkyl, amino, (C 1 -C 4)alkylamino, di (C 1 -C 4)alkylamino, amido, (C 1 -C 4)alkylamido, di (C 1 -C 4)alkylamido, halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, aryl, heteroaryl, heterocycloalkyl, or cycloalkyl; or, taken together, R 5 and R 6, or R 7 and R 8 may form a 5, 6, or 7-membered carbocycle or heterocycle, wherein said carbocycle or heterocycle is optionally substituted with R 9; R 9 is selected from the group consisting of: halogen, (C 1 -C 4)alkyl, halo(C 1 -C 4)alkyl, hydroxy, (C 1 -C 4)alkoxy, halo(C 1 -C 4)alkoxy, amino, (C 1 -C 4)alkylamino and di(C 1 -C 4)alkylamino.