mhurhangee/ep-ind-claims huggingface dataset:
A method for in vitro screening a test compound for toxicity or teratogenicity to human embryonic stem cells (hESCs) or hESC-derived lineage-specific cells contacted with the test compound, the method comprising the steps of: a) culturing hESCs or hESC-derived lineage-specific cells in the presence or absence of a test compound; b) separating a plurality of cellular metabolites of from 10 to 1500 Daltons that are secreted from hESCs or hESC-derived lineage specific cells; c) detecting one or a plurality of the cellular metabolites separated in step b); and d) identifying the effect of a test compound on hESCs or hESC-derived lineage- specific cells by identifying one or a plurality of cellular metabolites detected in step c) that are differentially secreted between cells cultured in the presence or the absence of the test compound. a) culturing hESCs or hESC-derived lineage-specific cells in the presence or absence of a test compound; b) separating a plurality of cellular metabolites of from 10 to 1500 Daltons that are secreted from hESCs or hESC-derived lineage specific cells; c) detecting one or a plurality of the cellular metabolites separated in step b); and d) identifying the effect of a test compound on hESCs or hESC-derived lineage- specific cells by identifying one or a plurality of cellular metabolites detected in step c) that are differentially secreted between cells cultured in the presence or the absence of the test compound.
A method for determining whether a subject having sepsis has an Inflammopathic phenotype, an Adaptive phenotype or a Coagulopathic phenotype, comprising: (a) measuring the amount of RNA transcripts encoded by at least two of ARG1, LCN2, LTF, OLFM4, HLA-DMB, YKT6, PDE4B, TWISTNB, BTN2A2, ZBTB33, PSMB9, CAMK4, TMEM19, SLC12A7, TP53BP1, PLEKHO1, SLC25A22, FRS2, GADD45A, CD24, S100A12, STX1A, KCNMB4, CRISP2, HTRA1, PPL, RHBDF2, ZCCHC4, YKT6, DDX6, SENP5, RAPGEF1, DTX2 and RELB in a sample of RNA obtained from the subject, to obtain gene expression data; and (b) based on the gene expression data, providing a report indicating whether the subject has an Inflammopathic phenotype, an Adaptive phenotype or a Coagulopathic phenotype, wherein: (i) increased ARG1, LCN2, LTF, and/or OLFM4 and/or decreased HLA-DMB indicates that the subject has an Inflammopathic phenotype; (ii) increased YKT6, PDE4B, TWISTNB, BTN2A2, ZBTB33, PSMB9, CAMK4, TMEM19, SLC12A7, TP53BP1, PLEKHO1, SLC25A22, and/or FRS2 and/or decreased GADD45A, CD24, S100A12, and/or STX1A indicates that the subject has an Adaptive phenotype; and (iii) increased KCNMB4, CRISP2, HTRA1, and/or PPL and/or decreased RHBDF2, ZCCHC4, YKT6, DDX6, SENP5, RAPGEF1, DTX2 and/or RELB indicates that the subject has a Coagulopathic phenotype. (a) measuring the amount of RNA transcripts encoded by at least two of ARG1, LCN2, LTF, OLFM4, HLA-DMB, YKT6, PDE4B, TWISTNB, BTN2A2, ZBTB33, PSMB9, CAMK4, TMEM19, SLC12A7, TP53BP1, PLEKHO1, SLC25A22, FRS2, GADD45A, CD24, S100A12, STX1A, KCNMB4, CRISP2, HTRA1, PPL, RHBDF2, ZCCHC4, YKT6, DDX6, SENP5, RAPGEF1, DTX2 and RELB in a sample of RNA obtained from the subject, to obtain gene expression data; and (b) based on the gene expression data, providing a report indicating whether the subject has an Inflammopathic phenotype, an Adaptive phenotype or a Coagulopathic phenotype, wherein: (i) increased ARG1, LCN2, LTF, and/or OLFM4 and/or decreased HLA-DMB indicates that the subject has an Inflammopathic phenotype; (ii) increased YKT6, PDE4B, TWISTNB, BTN2A2, ZBTB33, PSMB9, CAMK4, TMEM19, SLC12A7, TP53BP1, PLEKHO1, SLC25A22, and/or FRS2 and/or decreased GADD45A, CD24, S100A12, and/or STX1A indicates that the subject has an Adaptive phenotype; and (iii) increased KCNMB4, CRISP2, HTRA1, and/or PPL and/or decreased RHBDF2, ZCCHC4, YKT6, DDX6, SENP5, RAPGEF1, DTX2 and/or RELB indicates that the subject has a Coagulopathic phenotype. (i) increased ARG1, LCN2, LTF, and/or OLFM4 and/or decreased HLA-DMB indicates that the subject has an Inflammopathic phenotype; (ii) increased YKT6, PDE4B, TWISTNB, BTN2A2, ZBTB33, PSMB9, CAMK4, TMEM19, SLC12A7, TP53BP1, PLEKHO1, SLC25A22, and/or FRS2 and/or decreased GADD45A, CD24, S100A12, and/or STX1A indicates that the subject has an Adaptive phenotype; and (iii) increased KCNMB4, CRISP2, HTRA1, and/or PPL and/or decreased RHBDF2, ZCCHC4, YKT6, DDX6, SENP5, RAPGEF1, DTX2 and/or RELB indicates that the subject has a Coagulopathic phenotype.
Peptide comprising at least one amino acid sequence which binds to amyloid beta species and in which the negative charge of the carboxyl group normally present at the free C-terminus has been removed by modification so that there is no charge or a positive charge, wherein an acid amide group (CONH2 group) is present at the free C-terminus in place of the carboxyl group, comprising at least one monomer having an amino acid sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6.
A data processing method suitable for a system including an image processing apparatus capable of processing a plurality of jobs, the image processing apparatus including storage means for storing the jobs and setting means for setting any one of a plurality of erasing methods to each of a plurality of operating modes of the image processing apparatus, the data processing method comprising: an input step of inputting a job including data to process an image according to an operation mode of the image processing apparatus; a determining step of determining and storing an erasing method for the data in the job input in the input step in accordance with the operation mode of the job; a control step of processing a job in the operating mode (S1310 to S1312); a checking step of, upon completion of processing of the job, checking whether or not the erasing method for the operation mode of the job corresponds to the stored erasing method, and, in a case where the erasing method for the operation mode of the job does not correspond to the stored erasing method, not performing any erasure on the job (S1322, NO); and an erasing step of erasing the job input by the input step in response to completion of the job in accordance with the erasing method determined by the determining step if the erasing method for the operation mode of the job corresponds to the stored erasing method. an input step of inputting a job including data to process an image according to an operation mode of the image processing apparatus; a determining step of determining and storing an erasing method for the data in the job input in the input step in accordance with the operation mode of the job; a control step of processing a job in the operating mode (S1310 to S1312); a checking step of, upon completion of processing of the job, checking whether or not the erasing method for the operation mode of the job corresponds to the stored erasing method, and, in a case where the erasing method for the operation mode of the job does not correspond to the stored erasing method, not performing any erasure on the job (S1322, NO); and an erasing step of erasing the job input by the input step in response to completion of the job in accordance with the erasing method determined by the determining step if the erasing method for the operation mode of the job corresponds to the stored erasing method.
A method for producing a storable and swellable molded body made of bacterial cellulose, wherein the method has the steps of: i) providing a molded body made of bacterial cellulose; ii) optionally, mechanically pressing the entire molded body or parts of the molded body at temperatures in the range of 10°C to 100°C and pressures in the range of 0.01 to 1 MPa for a pressing time of 10 - 200 min; iii) treating the molded body with a solution of 20% by weight to 50% by weight of glycerol and 50% by weight to 80% by weight of a C1-C3-alcohol/water mixture; and iv) drying the treated molded body. i) providing a molded body made of bacterial cellulose; ii) optionally, mechanically pressing the entire molded body or parts of the molded body at temperatures in the range of 10°C to 100°C and pressures in the range of 0.01 to 1 MPa for a pressing time of 10 - 200 min; iii) treating the molded body with a solution of 20% by weight to 50% by weight of glycerol and 50% by weight to 80% by weight of a C1-C3-alcohol/water mixture; and iv) drying the treated molded body.
A composition comprising an effective amount of a hydroxypropyl-beta-cyclodextrin for use in the treatment of Alzheimer's disease in a human patient suffering from Alzheimer's disease, wherein the hydroxypropyl-beta-cyclodextrin composition is administered in a monthly dose amount of about 500 mg/kg to about 1500 mg/kg.
Apparatus for filling capillary tubes of a positive plate electrode of a lead accumulator with pasty active mass, comprising: a first conveying device having an outlet for the active mass, a filling collector tube (3, 3') that is fluidly connected to the outlet of the conveying device, and a plurality of filling tubes which protrude from the filling collector tube (3, 3') and are respectively arranged and configured in such a way that a capillary tube can be slid onto one of the filling tubes with a sliding fit, characterized in that at least one second conveying device (2a, 2b; 2a', 2b') is interposed between the first conveying device and the filling collector tube (3, 3'), the second filling device (2a, 2b; 2a', 2b'), when operated according to intended use, producing a defined filling pressure at at least one filling end of the filling collector tube or along the longitudinal extension of the filling collector tube.
A method in a radio base station (120, 600), of assigning a preamble to a user equipment, UE (110, 700), for enabling said UE (110, 700) to perform a random access, said radio base station being allocated a first set forming a pool of non-dedicated random access preambles and a second set forming a pool of dedicated random access preambles, the method comprising the steps of: - determining a dedicated random access preamble, of the second set, available for assignment to said UE; and - transmitting a message to the UE (110, 700), the message comprises an identification number of said available dedicated random access preamble, and further comprising a field with a binary value corresponding to an index indicating for which several PRACH occurrences, out of the PRACH occurrences of a predefined PRACH configuration, the dedicated random access preamble is valid to be used by the UE (110, 700) for random access, wherein a table contains values indicating the several PRACH occurrences. - determining a dedicated random access preamble, of the second set, available for assignment to said UE; and - transmitting a message to the UE (110, 700), the message comprises an identification number of said available dedicated random access preamble, and further comprising a field with a binary value corresponding to an index indicating for which several PRACH occurrences, out of the PRACH occurrences of a predefined PRACH configuration, the dedicated random access preamble is valid to be used by the UE (110, 700) for random access, wherein a table contains values indicating the several PRACH occurrences.
Unit mounting for an electric vehicle, wherein the unit mounting comprises a drive unit, a subframe, first and second unit bearings (34, 36, 35, 38) and unit supports (40, 46, 48), wherein at least one first unit bearing (34, 36) and one second unit bearing (35, 38) are arranged on a subframe so as to be spaced apart from one another in vehicle transverse direction (y), and the unit bearings (34, 35, 36, 38) each support the drive unit by means of a unit support (40, 46, 48), wherein the first unit bearing (34, 36) and the second unit bearing (35, 38) are arranged on a transverse beam (24, 30) of the subframe asymmetrically, offset relative to one another in vehicle vertical direction (z) and in vehicle longitudinal direction (x), characterised in that the asymmetrical first and second unit bearing (36, 38) each have a bearing axis, wherein the respective bearing axes are arranged offset relative to one another in vehicle vertical direction (z) and in vehicle longitudinal direction (x), starting from any central point, and wherein the transverse beam (24, 30) has a first bearing mount (32, 42) and a second bearing mount (33, 44) for respectively mounting the asymmetrical first unit bearing (34, 36) and second unit bearing (35, 38) and the first bearing mount (32, 42) and the second bearing mount (33, 44) are arranged respectively at the end regions of the transverse beam (24, 30). the first unit bearing (34, 36) and the second unit bearing (35, 38) are arranged on a transverse beam (24, 30) of the subframe asymmetrically, offset relative to one another in vehicle vertical direction (z) and in vehicle longitudinal direction (x), characterised in that the asymmetrical first and second unit bearing (36, 38) each have a bearing axis, wherein the respective bearing axes are arranged offset relative to one another in vehicle vertical direction (z) and in vehicle longitudinal direction (x), starting from any central point, and wherein the transverse beam (24, 30) has a first bearing mount (32, 42) and a second bearing mount (33, 44) for respectively mounting the asymmetrical first unit bearing (34, 36) and second unit bearing (35, 38) and the first bearing mount (32, 42) and the second bearing mount (33, 44) are arranged respectively at the end regions of the transverse beam (24, 30).
A sensor system comprising a first sensor device comprising a touch controller connected with a plurality of first sensor electrodes and a second capacitive sensor device comprising a capacitive non-touching movement controller connected with a plurality of second capacitive sensor electrodes configured to detect a movement of an object relative to a detection surface, wherein one of the first sensor electrodes and one of the second capacitive sensor electrodes are placed to have a distance between each other, which defines a capacitive coupling (C PATH), wherein the sensor system may be operated in a first mode of operation using said first sensor device and in a second mode of operation using said second capacitive sensor device, wherein the sensor system is configured to be switched over from the first mode of operation into the second mode of operation, and wherein when switched over from the first mode of operation into the second mode of operation, while in the second mode of operation said one of the second capacitive sensor electrodes is connected to a sensor input of the capacitive non-touching movement controller and said one of the first sensor electrodes is connected to a sensor input of the touch controller, the first sensor device comprises at least one signal path connected with a predetermined fixed electric potential, which is parallel to a parasitic capacitance (C PARA) of the first sensor device, wherein the parasitic capacitance (C PARA) is connected between a connection node of the controller that is connected with said one of the first sensor electrodes and said predetermined fixed electric potential.
Method for manufacturing open or closed annular structural components made of light metal and light metal alloys, with a two- or three-dimensional structure created by means of extrusion, wherein the extruded profile emerging from the die of the extruder is formed into a helix shape by means of one or more guide tools whose ends overlap slightly, whereupon the helix shape is separated from the extruded strand in the region of the overlap and is formed by a calibrating device into a ready-to-install two- or three-dimensional structural component, the structural component being formed in any approximately polygonal shape with radii provided in the corner regions which may be constant or increasing or decreasing; the calibration device consisting of a two-part calibration tool and embossing dies, cutting or punching tools are integrated in one or both tool halves by which embossing operations can be carried out in the surfaces and/or cutting and/or punching operations during the calibration process.
A water current power generating system, the system comprising: a support structure for location on a bed of a body of water, a power generating apparatus adapted for mounting on the support structure and operable to generate electrical power from a water current flowing past the system, a measurement unit housed within a main body of the power generating apparatus and operable to determine operating information relating to operation of the system wherein the operating information includes operating condition information relating to at least one operating condition of the system, the at least one operating condition being chosen from: inclination of the power generating apparatus, rate of change of inclination of the power generating apparatus, relative inclination between the power generating apparatus and the support structure, rate of change of relative inclination between the power generating apparatus and the support structure, wave height, wave period, and turbulence measurements; and a controller housed within a main body of the power generating apparatus, characterized in that the controller being operable to determine loading on the system from such operating information, and to adjust a controlled parameter of the system so as to cause the power output of the system to rise, and such that loading on the system falls. a support structure for location on a bed of a body of water, a power generating apparatus adapted for mounting on the support structure and operable to generate electrical power from a water current flowing past the system, a measurement unit housed within a main body of the power generating apparatus and operable to determine operating information relating to operation of the system wherein the operating information includes operating condition information relating to at least one operating condition of the system, the at least one operating condition being chosen from: inclination of the power generating apparatus, rate of change of inclination of the power generating apparatus, relative inclination between the power generating apparatus and the support structure, rate of change of relative inclination between the power generating apparatus and the support structure, wave height, wave period, and turbulence measurements; and a controller housed within a main body of the power generating apparatus, characterized in that the controller being operable to determine loading on the system from such operating information, and to adjust a controlled parameter of the system so as to cause the power output of the system to rise, and such that loading on the system falls.
A method of determining whether a subject is suffering from, or having a risk of suffering from, type 2 diabetes (T2D) or impaired glucose tolerance, said method comprising: determining an amount of imidazole propionate in a body sample from said subject; determining an amount of urocanate in said body sample; and determining whether said subject is suffering from, or having a risk of suffering from, type 2 diabetes or impaired glucose tolerance based on said determined amount of imidazole propionate and said determined amount of urocanate. determining an amount of imidazole propionate in a body sample from said subject; determining an amount of urocanate in said body sample; and determining whether said subject is suffering from, or having a risk of suffering from, type 2 diabetes or impaired glucose tolerance based on said determined amount of imidazole propionate and said determined amount of urocanate.
A composition for use in occluding a dentinal tubule within a mammalian tooth by applying to the tooth surface the composition comprising: a) isolated theobromine, or a salt or double salt thereof, or a co-crystal comprising theobromine; b) a source of calcium selected from the group consisting of calcium chloride, calcium carbonate, calcium gluconate, calcium phosphate, calcium acetate, and combinations thereof; and c) a source of phosphate selected from the group consisting of potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, and combinations thereof. a) isolated theobromine, or a salt or double salt thereof, or a co-crystal comprising theobromine; b) a source of calcium selected from the group consisting of calcium chloride, calcium carbonate, calcium gluconate, calcium phosphate, calcium acetate, and combinations thereof; and c) a source of phosphate selected from the group consisting of potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, and combinations thereof.
A device in the form of a tube or catheter for draining or sealing a natural or artificial bladder outlet, comprising a shaft body that can be applied extracorporeally into the bladder, as well as a balloon that surrounds it like a cuff with (i) an intra-vesically placeable balloon segment for the vesical anchoring of the shaft body in the bladder, as well as (ii) a transurethral balloon segment, which extends into the urethra or through the urethra for the purpose of a transurethral sealing, characterized in that the transurethral balloon segment is preformed with a residual diameter, which exceeds the diameter of the urethral lumen by 0.5 to 1.5 times, preferably by 0.5 to 1.0 times.
An antimicrobial therapeutic aqueous composition comprising (a) a silver salt, (b) acemannan; wherein the silver salt is anhydrous with less than 10% retained water or hydrous with greater than 10% retained water, wherein the silver salt is stabilized, and wherein the silver salt has a concentration of ionic silver in the range 0.01-1000 ppm. (a) a silver salt, (b) acemannan;