A medical device for delivery of a therapeutic agent with a combined release profile, the device comprising: an implantable medical device (10, 100); a first plurality of openings formed in the implantable medical device containing a first beneficial agent for delivery to tissue, wherein the first beneficial agent comprises a therapeutic agent and a first matrix, wherein the therapeutic agent and first matrix are arranged to deliver the therapeutic agent from the first plurality of openings according to a first release curve; and a second plurality of openings formed in the implantable medical device containing a second beneficial agent for delivery to tissue, wherein the second beneficial agent comprises the therapeutic agent and a second matrix, wherein the therapeutic agent and second matrix are arranged to deliver the therapeutic agent from the second plurality of openings according to a second release curve which is substantially different from the first release curve, and wherein the first and second openings together create a combination release kinetic, characterised in that the first release curve has an administration period of less than 1⁄2 an administration period of the second release curve. an implantable medical device (10, 100); a first plurality of openings formed in the implantable medical device containing a first beneficial agent for delivery to tissue, wherein the first beneficial agent comprises a therapeutic agent and a first matrix, wherein the therapeutic agent and first matrix are arranged to deliver the therapeutic agent from the first plurality of openings according to a first release curve; and a second plurality of openings formed in the implantable medical device containing a second beneficial agent for delivery to tissue, wherein the second beneficial agent comprises the therapeutic agent and a second matrix, wherein the therapeutic agent and second matrix are arranged to deliver the therapeutic agent from the second plurality of openings according to a second release curve which is substantially different from the first release curve, and wherein the first and second openings together create a combination release kinetic, a first plurality of openings formed in the implantable medical device containing a first beneficial agent for delivery to tissue, wherein the first beneficial agent comprises a therapeutic agent and a first matrix, wherein the therapeutic agent and first matrix are arranged to deliver the therapeutic agent from the first plurality of openings according to a first release curve; and a second plurality of openings formed in the implantable medical device containing a second beneficial agent for delivery to tissue, wherein the second beneficial agent comprises the therapeutic agent and a second matrix, wherein the therapeutic agent and second matrix are arranged to deliver the therapeutic agent from the second plurality of openings according to a second release curve which is substantially different from the first release curve, and wherein the first and second openings together create a combination release kinetic, characterised in that the first release curve has an administration period of less than 1⁄2 an administration period of the second release curve.