A signal transmission method, comprising: selecting, by a transmitter in a cell, a multiplexing mode of signals to be transmitted by a receiver according to both interference strength experienced by the cell and interference strength experienced by a neighboring cell or according to the interference strength experienced by the neighboring cell; notifying, by the transmitter in the cell, the receiver of the multiplexing mode, so that the receiver transmits the signals according to the multiplexing mode; wherein the selecting the multiplexing mode of signals to be transmitted by the receiver according to both the interference strength experienced by the cell and the interference strength experienced by the neighboring cell or according to the interference strength experienced by the neighboring cell comprises: if the interference strength experienced by the cell and the interference strength experienced by the neighboring cell is greater than or equal to a first threshold or the interference strength experienced by the neighboring cell is greater than or equal to the first threshold, selecting, by the transmitter in the cell, a code division multiplexing, CDM, mode; otherwise, selecting a second multiplexing mode, wherein the second multiplexing mode is an orthogonal frequency division multiplexing, OFDM, mode, or a single carrier frequency division multiple access, SC-FDMA, mode, or a frequency division multiplexing, FDM, mode, or a time division multiplexing, TDM, mode. selecting, by a transmitter in a cell, a multiplexing mode of signals to be transmitted by a receiver according to both interference strength experienced by the cell and interference strength experienced by a neighboring cell or according to the interference strength experienced by the neighboring cell; notifying, by the transmitter in the cell, the receiver of the multiplexing mode, so that the receiver transmits the signals according to the multiplexing mode; wherein the selecting the multiplexing mode of signals to be transmitted by the receiver according to both the interference strength experienced by the cell and the interference strength experienced by the neighboring cell or according to the interference strength experienced by the neighboring cell comprises: if the interference strength experienced by the cell and the interference strength experienced by the neighboring cell is greater than or equal to a first threshold or the interference strength experienced by the neighboring cell is greater than or equal to the first threshold, selecting, by the transmitter in the cell, a code division multiplexing, CDM, mode; otherwise, selecting a second multiplexing mode, wherein the second multiplexing mode is an orthogonal frequency division multiplexing, OFDM, mode, or a single carrier frequency division multiple access, SC-FDMA, mode, or a frequency division multiplexing, FDM, mode, or a time division multiplexing, TDM, mode. if the interference strength experienced by the cell and the interference strength experienced by the neighboring cell is greater than or equal to a first threshold or the interference strength experienced by the neighboring cell is greater than or equal to the first threshold, selecting, by the transmitter in the cell, a code division multiplexing, CDM, mode; otherwise, selecting a second multiplexing mode, wherein the second multiplexing mode is an orthogonal frequency division multiplexing, OFDM, mode, or a single carrier frequency division multiple access, SC-FDMA, mode, or a frequency division multiplexing, FDM, mode, or a time division multiplexing, TDM, mode.