The method for preparing micelles comprising a compound of Formula, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof; wherein the method comprises: adding an amount of the compound of Formula, a pharmaceutically acceptable salt thereof, and/or a stereoisomer thereof to a first aqueous alkaline solution having a pH from 10 to 12, comprising at least one basic metal salt, at least one neutral metal salt, and a predetermined concentration of metal ion, wherein the concentration of the compound of Formula in the first aqueous solution is higher than the critical micelle concentration, and wherein the pH of the first aqueous alkaline solution is higher than the pKa of the at least one ionizable group of the compound of Formula; thereby forming a second aqueous alkaline solution comprising micelles of the compound of Formula, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof with a preselected hydrodynamic diameter, wherein the compound of Formula is: wherein R 1 is selected from the group consisting of: and J, K and Q are each independently a straight or branched C 1-15 alkyl; L is O, N or C; M is O or N; G is N, O, S, SO or SO 2; R 2 is a straight or branched C 5-15 alkyl; R 3 is selected from the group consisting of: and E is N, O, S, SO or SO 2; A, B and D are each independently a straight or branched C 1-15 alkyl group; R 4 is a straight or branched C 4-20 alkyl group or U and V are each independently a straight or branched C 2-15 alkyl group; W is a hydrogen or a straight or branched C 1-5 alkyl group; R 5 is hydrogen, -J', -J'-OH, -J'-O-K', -J'-O-K'-OH or J'-O-PO 2; J' and K' are each independently a straight or branched C 1-5 alkyl group; R 6 is hydroxy, halogen, a C 1-5 alkoxy group or a C 1-5 acyloxy group; A 1 and A 2 are each independently selected from the group consisting of: Z is a straight or branched C 1-10 alkyl group. adding an amount of the compound of Formula, a pharmaceutically acceptable salt thereof, and/or a stereoisomer thereof to a first aqueous alkaline solution having a pH from 10 to 12, comprising at least one basic metal salt, at least one neutral metal salt, and a predetermined concentration of metal ion, wherein the concentration of the compound of Formula in the first aqueous solution is higher than the critical micelle concentration, and wherein the pH of the first aqueous alkaline solution is higher than the pKa of the at least one ionizable group of the compound of Formula; forming a second aqueous alkaline solution comprising micelles of the compound of Formula, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof with a preselected hydrodynamic diameter, wherein the compound of Formula is: wherein R 1 is selected from the group consisting of: and J, K and Q are each independently a straight or branched C 1-15 alkyl; L is O, N or C; M is O or N; G is N, O, S, SO or SO 2; R 2 is a straight or branched C 5-15 alkyl; R 3 is selected from the group consisting of: and E is N, O, S, SO or SO 2; A, B and D are each independently a straight or branched C 1-15 alkyl group; R 4 is a straight or branched C 4-20 alkyl group or U and V are each independently a straight or branched C 2-15 alkyl group; W is a hydrogen or a straight or branched C 1-5 alkyl group; R 5 is hydrogen, -J', -J'-OH, -J'-O-K', -J'-O-K'-OH or J'-O-PO 2; J' and K' are each independently a straight or branched C 1-5 alkyl group; R 6 is hydroxy, halogen, a C 1-5 alkoxy group or a C 1-5 acyloxy group; A 1 and A 2 are each independently selected from the group consisting of: Z is a straight or branched C 1-10 alkyl group. J, K and Q are each independently a straight or branched C 1-15 alkyl; L is O, N or C; M is O or N; G is N, O, S, SO or SO 2; R 2 is a straight or branched C 5-15 alkyl; R 3 is selected from the group consisting of: E is N, O, S, SO or SO 2; A, B and D are each independently a straight or branched C 1-15 alkyl group; R 4 is a straight or branched C 4-20 alkyl group or U and V are each independently a straight or branched C 2-15 alkyl group; W is a hydrogen or a straight or branched C 1-5 alkyl group; R 5 is hydrogen, -J', -J'-OH, -J'-O-K', -J'-O-K'-OH or J'-O-PO 2; J' and K' are each independently a straight or branched C 1-5 alkyl group; R 6 is hydroxy, halogen, a C 1-5 alkoxy group or a C 1-5 acyloxy group; A 1 and A 2 are each independently selected from the group consisting of: Z is a straight or branched C 1-10 alkyl group.