A handheld diabetes data management unit having an analyte test sensor, a processor coupled to a memory and display screen, the handheld diabetes data management unit comprising: means for measuring a plurality of blood glucose concentration values of a user with the analyte test sensor over a plurality of time periods; means for collecting data representative of a plurality of fasting blood glucose concentration values of the plurality of measured blood glucose concentration values with the handheld diabetes data management unit; means for ascertaining from the collected data that the user has not missed two or more fasting glucose measurements in the last four days before the ascertaining, that a fasting glucose measurement was not missed the day before the ascertaining, that fasting glucose concentration values were not within target for three consecutive days, that the fasting glucose concentration value was between a first low value and a low threshold for four consecutive days, and that the fasting glucose concentration value results were below the first low value for two consecutive days; means for determining whether the collected data indicate one of a first low blood glucose concentration pattern, thereby comprising comparing the collected data with a first low blood glucose concentration value, and a second low blood glucose concentration pattern, thereby comprising comparing the collected data with a second low blood glucose concentration value, wherein the second low blood glucose concentration value is lower than the first low blood glucose concentration value; and means for, upon determination of at least one of the first and second low blood glucose concentration patterns of the user, displaying safety notifications on the display screen of the handheld diabetes data management unit. means for measuring a plurality of blood glucose concentration values of a user with the analyte test sensor over a plurality of time periods; means for collecting data representative of a plurality of fasting blood glucose concentration values of the plurality of measured blood glucose concentration values with the handheld diabetes data management unit; means for ascertaining from the collected data that the user has not missed two or more fasting glucose measurements in the last four days before the ascertaining, that a fasting glucose measurement was not missed the day before the ascertaining, that fasting glucose concentration values were not within target for three consecutive days, that the fasting glucose concentration value was between a first low value and a low threshold for four consecutive days, and that the fasting glucose concentration value results were below the first low value for two consecutive days; means for determining whether the collected data indicate one of a first low blood glucose concentration pattern, thereby comprising comparing the collected data with a first low blood glucose concentration value, and a second low blood glucose concentration pattern, thereby comprising comparing the collected data with a second low blood glucose concentration value, wherein the second low blood glucose concentration value is lower than the first low blood glucose concentration value; and means for, upon determination of at least one of the first and second low blood glucose concentration patterns of the user, displaying safety notifications on the display screen of the handheld diabetes data management unit.