A therapeutic multimer compound formed from the multimerization in an aqueous media of a first monomer represented by: X 1 -Y 1 -Z 1 (Formula I) and a second monomer represented by X 2 -Y 2 -Z 2 (Formula II), wherein X 1 is a first ligand moiety capable of binding to a first target biomolecule; Y 1 is absent or is a connector moiety covalently bound to X 1 and Z 1; Z 1 is a first linker selected from the group consisting of: wherein A 3 is -OH; R 3 and R 4 are independently selected from the group consisting of H, C 1-4 alkyl, phenyl, or R 3 and R 4 taken together from a 3-6 membered ring; R 5 and R 6 are independently selected from the group consisting of H, C 1-4 alkyl optionally substituted by hydroxyl, amino, halogen, or thio; C 1-4 alkoxy; halogen; -OH; -CN; -COOH; -CONHR'; or R 5 and R 6 taken together form phenyl or a 4-6 membered heterocycle; and R' is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -NH 2, -NO 2, -SH, or -OH; wherein X 2 is a second ligand moiety having a molecular weight between 50 Da and 2000 Da, capable of binding to a second target biomolecule; Y 2 is absent or is a connector moiety covalently bound to X 2 and Z 2; and Z 2 is a second linker selected from the group consisting of: wherein R 8 is selected from the group consisting of H, halogen, oxo, C 1-4 alkyl optionally substituted by hydroxyl, amino, halo or thio; C 2-4 alkenyl, C 1-4 alkoxy; -S- C 1-4 alkyl; -CN; -COOH; or -CONHR'; and R' is H or C 1-4 alkyl; and pharmaceutically acceptable salts, stereoisomers, and hydrates thereof. X 1 is a first ligand moiety capable of binding to a first target biomolecule; Y 1 is absent or is a connector moiety covalently bound to X 1 and Z 1; Z 1 is a first linker selected from the group consisting of: wherein A 3 is -OH; R 3 and R 4 are independently selected from the group consisting of H, C 1-4 alkyl, phenyl, or R 3 and R 4 taken together from a 3-6 membered ring; R 5 and R 6 are independently selected from the group consisting of H, C 1-4 alkyl optionally substituted by hydroxyl, amino, halogen, or thio; C 1-4 alkoxy; halogen; -OH; -CN; -COOH; -CONHR'; or R 5 and R 6 taken together form phenyl or a 4-6 membered heterocycle; and R' is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -NH 2, -NO 2, -SH, or -OH; wherein A 3 is -OH; R 3 and R 4 are independently selected from the group consisting of H, C 1-4 alkyl, phenyl, or R 3 and R 4 taken together from a 3-6 membered ring; R 5 and R 6 are independently selected from the group consisting of H, C 1-4 alkyl optionally substituted by hydroxyl, amino, halogen, or thio; C 1-4 alkoxy; halogen; -OH; -CN; -COOH; -CONHR'; or R 5 and R 6 taken together form phenyl or a 4-6 membered heterocycle; and R' is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -NH 2, -NO 2, -SH, or -OH; X 2 is a second ligand moiety having a molecular weight between 50 Da and 2000 Da, capable of binding to a second target biomolecule; Y 2 is absent or is a connector moiety covalently bound to X 2 and Z 2; and Z 2 is a second linker selected from the group consisting of: wherein R 8 is selected from the group consisting of H, halogen, oxo, C 1-4 alkyl optionally substituted by hydroxyl, amino, halo or thio; C 2-4 alkenyl, C 1-4 alkoxy; -S- C 1-4 alkyl; -CN; -COOH; or -CONHR'; and R' is H or C 1-4 alkyl; and pharmaceutically acceptable salts, stereoisomers, and hydrates thereof. R 8 is selected from the group consisting of H, halogen, oxo, C 1-4 alkyl optionally substituted by hydroxyl, amino, halo or thio; C 2-4 alkenyl, C 1-4 alkoxy; -S- C 1-4 alkyl; -CN; -COOH; or -CONHR'; and R' is H or C 1-4 alkyl; and