A system for detecting and removing a gas bubble from a vascular infusion line, the system comprising: a disposable cassette adapted for disposition intermediate the fluid line, the disposable cassette comprising: - a body comprising an inlet port, an outlet port, and a purge port, a first passageway connected to the inlet port, the first passageway comprising a first bubble detection section where a gas bubble may be detected within the first passageway, a second passageway connected to the outlet port, and a first pinch valve disposed along the second passageway, and a third: passageway connected to the purge port, and a second pinch valve disposed along the third passageway, characterised by the disposable cassette comprising in addition a chamber, the first, second and third passageway (330, 340, 350) connecting the inlet port, the outlet port, and the purge port to the chamber, the first pinch valve being disposed intermediate the chamber and the outlet port, the third passageway comprising the second bubble detection section where a gas bubble may be detected within the third passageway, the second pinch valve being disposed intermediate the chamber and the second bubble detection section. a disposable cassette adapted for disposition intermediate the fluid line, the disposable cassette comprising: - a body comprising an inlet port, an outlet port, and a purge port, a first passageway connected to the inlet port, the first passageway comprising a first bubble detection section where a gas bubble may be detected within the first passageway, a second passageway connected to the outlet port, and a first pinch valve disposed along the second passageway, and a third: passageway connected to the purge port, and a second pinch valve disposed along the third passageway, characterised by the disposable cassette comprising in addition a chamber, the first, second and third passageway (330, 340, 350) connecting the inlet port, the outlet port, and the purge port to the chamber, the first pinch valve being disposed intermediate the chamber and the outlet port, the third passageway comprising the second bubble detection section where a gas bubble may be detected within the third passageway, the second pinch valve being disposed intermediate the chamber and the second bubble detection section. - a body comprising an inlet port, an outlet port, and a purge port, a first passageway connected to the inlet port, the first passageway comprising a first bubble detection section where a gas bubble may be detected within the first passageway, a second passageway connected to the outlet port, and a first pinch valve disposed along the second passageway, and a third: passageway connected to the purge port, and a second pinch valve disposed along the third passageway, characterised by the disposable cassette comprising in addition a chamber, the first, second and third passageway (330, 340, 350) connecting the inlet port, the outlet port, and the purge port to the chamber, the first pinch valve being disposed intermediate the chamber and the outlet port, the third passageway comprising the second bubble detection section where a gas bubble may be detected within the third passageway, the second pinch valve being disposed intermediate the chamber and the second bubble detection section.