A compound of Formula, or a pharmaceutically acceptable salt thereof: wherein: G 1 is -CR 4 R 5 -; G 2 is a bond; G 3 is -CR 8 - or -N-; R 1, R 3, R 4, R 5, and R 8 are each independently H, C 1 -C 6 alkyl, halo, or hydroxyl; R 2 is H, C 2 -C 6 alkyl, halo, or hydroxyl; Z is selected from the group consisting of a bond, C 1 -C 6 alkyl, -O-,-R x O-, and - OR y -; A is selected from the group consisting of unsubstituted phenyl, and 5- or 6-membered heteroaryl comprising at least one annular N atom, wherein the 5- or 6-membered heteroaryl is unsubstituted or substituted with one or more R 10 substituents; each R 10 is independently selected from the group consisting of -C OCH 3, methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl, wherein each methyl, ethyl and isopropyl of R 10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of -OCH 3, -OH, and -OC CH 3; B is selected from the group consisting of H, C 1 -C 6 alkyl, cycloalkyl, aryl, heterocycloalkyl, and heteroaryl, wherein the C 1 -C 6 alkyl, cycloalkyl, aryl, heterocycloalkyl, or heteroaryl of B is unsubstituted or substituted with one or more R 11 substituents; each R 11 is independently selected from the group consisting of substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, unsubstituted C 1 -C 6 alkyl, Ci-C 6 alkyl substituted with one or more R 12 substituents, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, halo, -OR b, -C R c, -C OR d, oxo, and -NR e R f; each R 12 is independently selected from the group consisting of halo, -OR b, - C R g, -C OR h, and -C NR i R j; each R b, R c, R d, R e, R f, R g, R h, and R j is independently H or C 1 -C 6 alkyl; and R x and R y are each C 1 -C 6 alkyl, wherein when A is unsubstituted phenyl, the -Z-B moiety is not - OC(CH 3) 3 or 1-ethyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-onyl. G 1 is -CR 4 R 5 -; G 2 is a bond; G 3 is -CR 8 - or -N-; R 1, R 3, R 4, R 5, and R 8 are each independently H, C 1 -C 6 alkyl, halo, or hydroxyl; R 2 is H, C 2 -C 6 alkyl, halo, or hydroxyl; Z is selected from the group consisting of a bond, C 1 -C 6 alkyl, -O-,-R x O-, and - OR y -; A is selected from the group consisting of unsubstituted phenyl, and 5- or 6-membered heteroaryl comprising at least one annular N atom, wherein the 5- or 6-membered heteroaryl is unsubstituted or substituted with one or more R 10 substituents; each R 10 is independently selected from the group consisting of -C OCH 3, methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl, wherein each methyl, ethyl and isopropyl of R 10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of -OCH 3, -OH, and -OC CH 3; B is selected from the group consisting of H, C 1 -C 6 alkyl, cycloalkyl, aryl, heterocycloalkyl, and heteroaryl, wherein the C 1 -C 6 alkyl, cycloalkyl, aryl, heterocycloalkyl, or heteroaryl of B is unsubstituted or substituted with one or more R 11 substituents; each R 11 is independently selected from the group consisting of substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, unsubstituted C 1 -C 6 alkyl, Ci-C 6 alkyl substituted with one or more R 12 substituents, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, halo, -OR b, -C R c, -C OR d, oxo, and -NR e R f; each R 12 is independently selected from the group consisting of halo, -OR b, - C R g, -C OR h, and -C NR i R j; each R b, R c, R d, R e, R f, R g, R h, and R j is independently H or C 1 -C 6 alkyl; and R x and R y are each C 1 -C 6 alkyl, wherein when A is unsubstituted phenyl, the -Z-B moiety is not - OC(CH 3) 3 or 1-ethyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-onyl.