An ion guide (152, 169, 199, 201, 202, 220, 224, 225) for the transmission of ions in a mass spectrometer, said ion guide (152, 169, 199, 201, 202, 220, 224, 225) comprising: a plurality of segmented and apertured electrodes (101-111, 101', 191-195), each said electrode (101-111, 101', 191-195) comprising alternating electrically insulating and electrically conducting segments (101a-111d; 101a'-101f') such that each said electrically conducting segment (101a-111d; 101a'-101f') is adjacent to at least two said electrically insulating segments; and a means for applying a first RF potential (250, 252) to a first set of said electrically conducting segments and a second RF potential (251, 253) to a second set of said electrically conducting segments; wherein each of said segmented electrodes (101-111, 101', 191-195) is composed of at least two of said electrically conducting segments (101a-111d; 101a'-101f'), wherein said electrodes (101-111, 101', 191-195) are aligned along a common axis (153, 205) such that said electrically conducting segments (101a-111d; 101a'-101f') of each said electrode (101-111, 101', 191-195) are aligned with said electrically conducting segments (101a-111d; 101a'-101f') of adjacent said electrodes (101-111, 101', 191-195), wherein said first set of electrically conducting segments are interleaved with said second set of electrically conducting segments such that only conducting segments (101a-111d; 101a'-101f') of said second set are adjacent along the axis (153, 205) of the ion guide (152, 169, 199, 201, 202, 220, 224, 225) to any given conducting segment (101a-111d; 101a'-101f') of said first set and vice versa, and wherein said first RF potential (250, 252) is out of phase with said second RF potential (251, 253). a plurality of segmented and apertured electrodes (101-111, 101', 191-195), each said electrode (101-111, 101', 191-195) comprising alternating electrically insulating and electrically conducting segments (101a-111d; 101a'-101f') such that each said electrically conducting segment (101a-111d; 101a'-101f') is adjacent to at least two said electrically insulating segments; and a means for applying a first RF potential (250, 252) to a first set of said electrically conducting segments and a second RF potential (251, 253) to a second set of said electrically conducting segments; wherein each of said segmented electrodes (101-111, 101', 191-195) is composed of at least two of said electrically conducting segments (101a-111d; 101a'-101f'), wherein said electrodes (101-111, 101', 191-195) are aligned along a common axis (153, 205) such that said electrically conducting segments (101a-111d; 101a'-101f') of each said electrode (101-111, 101', 191-195) are aligned with said electrically conducting segments (101a-111d; 101a'-101f') of adjacent said electrodes (101-111, 101', 191-195), wherein said first set of electrically conducting segments are interleaved with said second set of electrically conducting segments such that only conducting segments (101a-111d; 101a'-101f') of said second set are adjacent along the axis (153, 205) of the ion guide (152, 169, 199, 201, 202, 220, 224, 225) to any given conducting segment (101a-111d; 101a'-101f') of said first set and vice versa, and wherein said first RF potential (250, 252) is out of phase with said second RF potential (251, 253).