An aerosol delivery device comprising: a power unit comprising: a power unit housing having a distal end, a proximal end, and a longitudinal axis extending between the distal end and the proximal end; a power source positioned within the power unit housing; a first interface defined at the proximal end of the power unit housing; and processing circuitry; and a cartridge that is coupleable with the power unit, the cartridge comprising: a cartridge housing having a distal end defining a second interface, a proximal end, and a longitudinal axis extending between the distal end and the proximal end, the cartridge housing being configured for containing an aerosol precursor composition; and a vaporizer positioned within the cartridge housing and operable to vaporize the aerosol precursor composition upon delivery of power from the power source of the power unit; wherein the cartridge is configured for rotation about the longitudinal axis of the cartridge housing so as to be coupleable with the power unit in at least a first orientation relative to the power unit and a second, different orientation relative to the power unit; and wherein the processing circuitry of the power unit is configured for detection of whether the cartridge is present in the first orientation or the second, different orientation and executing a control function assigned to the respective orientation. a power unit comprising: a power unit housing having a distal end, a proximal end, and a longitudinal axis extending between the distal end and the proximal end; a power source positioned within the power unit housing; a first interface defined at the proximal end of the power unit housing; and processing circuitry; and a power unit housing having a distal end, a proximal end, and a longitudinal axis extending between the distal end and the proximal end; a power source positioned within the power unit housing; a first interface defined at the proximal end of the power unit housing; and processing circuitry; and a cartridge that is coupleable with the power unit, the cartridge comprising: a cartridge housing having a distal end defining a second interface, a proximal end, and a longitudinal axis extending between the distal end and the proximal end, the cartridge housing being configured for containing an aerosol precursor composition; and a vaporizer positioned within the cartridge housing and operable to vaporize the aerosol precursor composition upon delivery of power from the power source of the power unit; a cartridge housing having a distal end defining a second interface, a proximal end, and a longitudinal axis extending between the distal end and the proximal end, the cartridge housing being configured for containing an aerosol precursor composition; and a vaporizer positioned within the cartridge housing and operable to vaporize the aerosol precursor composition upon delivery of power from the power source of the power unit; wherein the cartridge is configured for rotation about the longitudinal axis of the cartridge housing so as to be coupleable with the power unit in at least a first orientation relative to the power unit and a second, different orientation relative to the power unit; and wherein the processing circuitry of the power unit is configured for detection of whether the cartridge is present in the first orientation or the second, different orientation and executing a control function assigned to the respective orientation.