mhurhangee/ep-ind-claims huggingface dataset:
A recombinant nucleic acid molecule comprising a bidirectional promoter (hCMV-rhCMV promoter) operably linked to a first transgene in one direction and to a second transgene in the opposite direction, wherein the hCMV-rhCMV promoter comprises: (i) an enhancer, flanked by (ii) a human cytomegalovirus major immediate early promoter (hCMV promoter) on one side of the enhancer, and (iii) a rhesus cytomegalovirus major immediate early promoter (rhCMV promoter) on the other side of the enhancer, wherein (iv) the first transgene is located downstream of the hCMV promoter, and (v) the second transgene is located downstream of the rhCMV promoter. (i) an enhancer, flanked by (ii) a human cytomegalovirus major immediate early promoter (hCMV promoter) on one side of the enhancer, and (iii) a rhesus cytomegalovirus major immediate early promoter (rhCMV promoter) on the other side of the enhancer, wherein (iv) the first transgene is located downstream of the hCMV promoter, and (v) the second transgene is located downstream of the rhCMV promoter.
Process for preparing compounds containing thioallophanate groups, comprising reaction of A) at least one component having at least one uretdione group with B) at least one component having at least one thiol group in the presence of C) at least one catalyst of the general formula in which R 1, R 2, R 3 and R 4 are independently identical or different radicals that are saturated or unsaturated, linear or branched, aliphatic, cycloaliphatic, araliphatic or aromatic organic radicals which have 1 to 18 carbon atoms and are substituted or unsubstituted and/or have heteroatoms in the chain, where R 1 and R 2, including in combination with one another, together with the nitrogen atom and optionally with any further heteroatom, may form heterocyclic rings which have 3 to 8 carbon atoms and may optionally have further substitution, with the proviso that at least one of the R 1 to R 4 radicals has at least two carbon atoms. A) at least one component having at least one uretdione group with B) at least one component having at least one thiol group in the presence of C) at least one catalyst of the general formula
A street cover for an extension spindle, said extension spindle comprising an attachment portion comprising at least one radially extending lug (24,26), said extension spindle further comprising a tool part spaced apart from said at least one radially extending lug, said street cover comprising: an upper housing part defining an upper cavity for housing said tool part of said extension spindle, said upper cavity being closeable by a cover assembly, and, a lower housing part defining a lower cavity for receiving said attachment portion and said at least one radially extending lug (24, 26), said lower cavity and said upper cavity being separated from each other by a wall, at least part of said wall defining a seat for engaging the upper side of said at least one radially extending lug (24, 26), said wall comprising an aperture for admitting said tool part into said upper cavity, characterized in that said lower housing part further comprises at least one set of two spaced apart holes (70, 72) for receiving and holding a retaining member, said at least one set of two spaced apart holes (70, 72) being positioned such that said retaining member engages the underside of said at least one radially extending lug (24, 26) for retaining said attachment portion in said lower cavity. an upper housing part defining an upper cavity for housing said tool part of said extension spindle, said upper cavity being closeable by a cover assembly, and, a lower housing part defining a lower cavity for receiving said attachment portion and said at least one radially extending lug (24, 26), said lower cavity and said upper cavity being separated from each other by a wall, at least part of said wall defining a seat for engaging the upper side of said at least one radially extending lug (24, 26), said wall comprising an aperture for admitting said tool part into said upper cavity, characterized in that said lower housing part further comprises at least one set of two spaced apart holes (70, 72) for receiving and holding a retaining member, said at least one set of two spaced apart holes (70, 72) being positioned such that said retaining member engages the underside of said at least one radially extending lug (24, 26) for retaining said attachment portion in said lower cavity.
A connection device comprising a cover including at least one opening and a sealing means, the sealing means including at least one elastically deformable sheath including a first end, connected in a watertight way to a peripheral edge of the opening, and a second end, the opening and the sheath allowing the movement of the second end of the sheath between an "extension position" and a "retraction position", characterised in that the sheath turns around on itself during the passage of the second end from the "extension position" to the "retraction position".
A composition comprising intentionally added synthetic mixed-metal oxide pigment particles, wherein at least 10 wt% of the synthetic mixed-metal oxide pigment particles have a McConnellite crystal structure having the formula Cu 1+ Cr 3+ O 2, and wherein the particles having the McConnellite crystal structure having the formula Cu 1+ Cr 3+ O 2 have a plate-like morphology.
A wheel set measuring device for wheel sets of rail vehicles, by means of which the wheel sets of rail vehicles, when fitted into the rail vehicles, can be checked for a reliable operating state and the adherence of operating limits, characterised in that the wheel set measuring device comprises two device sub-units (7, 8) separated from each other and movable along the floor separately from each other, which can each be pushed up to the wheel set and positioned when pushed up to the wheel set, and in that the wheel set measuring device is configured as a wheel set lifting and rotating device, wherein both wheel set sub-units (7, 8) are configured as a wheel set lifting device and at least one wheel set sub-unit is configured as a wheel set rotating and measuring device.
A broadcast signal transmitter comprising: an input formatting module configured to generate Physical Layer Pipe, PLP, data; a Bit Interleaved Coded Modulation, BICM, module configured to perform error correction processing on the PLP data; a framing module configured to generate a signal frame comprising the PLP data; and a waveform generating module configured to perform Orthogonal Frequency Division Multiplexing, OFDM, modulation on the signal frame, wherein the signal frame comprises a preamble and at least one subframe, wherein the at least one subframe includes at least one subframe boundary symbol, and the subframe boundary symbol has a greater scattered pilot, SP, density than data symbols of the subframe, and wherein at least one of a last symbol of an immediately preceding subframe or a first symbol of an immediately following subframe is the subframe boundary symbol for contiguous subframes when the signal frame comprises a plurality of subframes and Fast Fourier Transform, FFT, sizes of the contiguous subframes are different to each other. an input formatting module configured to generate Physical Layer Pipe, PLP, data; a Bit Interleaved Coded Modulation, BICM, module configured to perform error correction processing on the PLP data; a framing module configured to generate a signal frame comprising the PLP data; and a waveform generating module configured to perform Orthogonal Frequency Division Multiplexing, OFDM, modulation on the signal frame, wherein the signal frame comprises a preamble and at least one subframe, wherein the at least one subframe includes at least one subframe boundary symbol, and the subframe boundary symbol has a greater scattered pilot, SP, density than data symbols of the subframe, and wherein at least one of a last symbol of an immediately preceding subframe or a first symbol of an immediately following subframe is the subframe boundary symbol for contiguous subframes when the signal frame comprises a plurality of subframes and Fast Fourier Transform, FFT, sizes of the contiguous subframes are different to each other.
A refrigerator comprising: a body provided with a storage compartment; a door unit provided with a first door provided with an opening and rotatably coupled to the body to open or close to cause the storage compartment of the body to open or close, respectively, and a second door provided in front of the first door and configured to open or close to cause the opening of the first door to open or close, respectively; and a latch unit provided in the door unit and configured to selectively couple the second door to the first door; characterized by a first hinge unit on the body to support a rotation of the first door and provided with a push portion configured to selectively operate the latch unit according to the rotation of the first door to cause the latch unit to couple and decouple the second door to the first door based on the rotation of the first door, wherein the first door includes an auto close lever having one end portion thereof fixed to the first door and having an elasticity, and a roller rotatably installed in the other end portion that is opposite to the one end portion of the auto close lever, and wherein the push portion selectively makes contact with the roller and presses the roller toward a direction in which the first door is closed, when the first door is closed. a body provided with a storage compartment; a door unit provided with a first door provided with an opening and rotatably coupled to the body to open or close to cause the storage compartment of the body to open or close, respectively, and a second door provided in front of the first door and configured to open or close to cause the opening of the first door to open or close, respectively; and a latch unit provided in the door unit and configured to selectively couple the second door to the first door; characterized by a first hinge unit on the body to support a rotation of the first door and provided with a push portion configured to selectively operate the latch unit according to the rotation of the first door to cause the latch unit to couple and decouple the second door to the first door based on the rotation of the first door, wherein the first door includes an auto close lever having one end portion thereof fixed to the first door and having an elasticity, and a roller rotatably installed in the other end portion that is opposite to the one end portion of the auto close lever, and wherein the push portion selectively makes contact with the roller and presses the roller toward a direction in which the first door is closed, when the first door is closed.
A method of forming a clear polymer article comprising: a. forming a solid color concentrate by mixing a high molecular weight thermoplastic saturated polyester resin, a dispersant, and at least one colorant; and b. mixing the solid color concentrate with a melt-processible polymer selected from polycarbonate PC, polymethylmethacrylate PMMA, polyethylene terephthalate PET, PET modified with cyclohexanedimethanol PETG, copolyester, thermoplastic polyurethane TPU, polysulfone, specialty polyamides, or a combination of two or more thereof to form a polymeric article having less than 20% of haze as determined by ASTM D 1003. a. forming a solid color concentrate by mixing a high molecular weight thermoplastic saturated polyester resin, a dispersant, and at least one colorant; and b. mixing the solid color concentrate with a melt-processible polymer selected from polycarbonate PC, polymethylmethacrylate PMMA, polyethylene terephthalate PET, PET modified with cyclohexanedimethanol PETG, copolyester, thermoplastic polyurethane TPU, polysulfone, specialty polyamides, or a combination of two or more thereof to form a polymeric article having less than 20% of haze as determined by ASTM D 1003.
Dual coupling gear mechanism for a motor vehicle, having a first input shaft and a second input shaft and having a first and a second countershaft (32, 34), the input shafts (24, 26) and the countershafts (32, 34) being connected to each other by means of a plurality of shiftable wheel sets in order to establish at least seven forward gear stages and at least one reverse gear stage, wherein at least one wheel set (50, 58, 68; 48, 56, 66) has a fixed wheel (48; 50) which is connected to one of the input shafts (24, 26) and has two loose wheels (56, 66; 58, 68) which are rotatably supported on the first and on the second countershaft (32, 34), respectively and which are in engagement with the fixed wheel (48; 50), wherein there are arranged on the first countershaft a loose wheel which is associated with the second forward gear stage, a loose wheel which is associated with the sixth forward gear stage, a loose wheel (54'; 54"'; 54 IV) which is associated with the first forward gear stage and a loose wheel which is associated with the seventh forward gear stage, that is, in this sequence when viewed from a gear input, characterized in that there are arranged on the second countershaft a loose wheel which is associated with the reverse gear stage, a loose wheel which is associated with the fourth forward gear stage, a loose wheel (64'; 64") which is associated with the third forward gear stage and a loose wheel which is associated with the fifth forward gear stage, that is, in this sequence when viewed from a gear input, wherein an electric engine is connected to a loose wheel (68; 64'; 68"; 64") of one of the wheel sets or can be connected thereto by means of a shift clutch.
Locking assembly for a bicycle transmission chain, comprising at least one articulating pin and a corresponding locking button plastically deformable to prevent deformations or movements of inner walls of said articulating pin in a radial direction, towards a relative longitudinal axis, the articulating pin comprising a central portion and a distal end which is at least in part elastically deformable suitable for the insertion through aligned holes (17, 19) of an outer link and of a corresponding inner link of said chain, the articulating pin being of the type intended to hinge said links (5, 10) to one another, characterised in that said locking button comprises an inner cavity suitable for the insertion of an outer deformation tool and/or of a guide element of the articulating pin in the insertion in the holes (17, 19) of said outer and inner links (5, 10).
A system for providing respiratory therapy to a patient comprising: a patient interface (108, 408, 808, 908) adapted to present a respiratory gas at an entrance to a patient's airways; an air delivery conduit (106, 406A, 406B, 406C, 906) connected to the patient interface; and apparatus (102, 302, 402) to provide a controllable supply of air having a flow rate, a temperature and a humidity, the apparatus being controlled to vary at least one of flow rate, temperature and humidity, the apparatus being adapted to deliver toward the patient a first level of humidification during an inspiratory portion of a respiratory cycle of a patient and a second level of humidification during an expiratory portion of the respiratory cycle, wherein two air streams are provided comprising a first relatively dry air stream in one flow channel, and a second relatively moist air stream in another flow channel and mixed to a third flow channel to rapidly change a level of humidification as necessitated by settings of the apparatus. a patient interface (108, 408, 808, 908) adapted to present a respiratory gas at an entrance to a patient's airways; an air delivery conduit (106, 406A, 406B, 406C, 906) connected to the patient interface; and apparatus (102, 302, 402) to provide a controllable supply of air having a flow rate, a temperature and a humidity, the apparatus being controlled to vary at least one of flow rate, temperature and humidity, the apparatus being adapted to deliver toward the patient a first level of humidification during an inspiratory portion of a respiratory cycle of a patient and a second level of humidification during an expiratory portion of the respiratory cycle, wherein two air streams are provided comprising a first relatively dry air stream in one flow channel, and a second relatively moist air stream in another flow channel and mixed to a third flow channel to rapidly change a level of humidification as necessitated by settings of the apparatus.
A method of wireless communication at a user equipment, UE, comprising: communicating with an evolved node B, eNB, over a frequency channel of a shared frequency band in which a clear channel assessment, CCA, procedure is in operation to reserve the frequency channel; receiving a downlink, DL, data transmission from the eNB over the frequency channel of the shared frequency band; determining acknowledgement/negative acknowledgement, ACK/NACK, information for the data transmission; and transmitting the ACK/NACK information in a CCA-exempt feedback transmission to the eNB via the frequency channel of the shared frequency band, wherein the ACK/NACK information is mapped to designated resources of an uplink control channel structure for the CCA-exempt feedback transmission and characterized in that the start of the CCA-exempt feedback transmission occurs less than a predetermined CCA time period from the end of the DL data transmission. communicating with an evolved node B, eNB, over a frequency channel of a shared frequency band in which a clear channel assessment, CCA, procedure is in operation to reserve the frequency channel; receiving a downlink, DL, data transmission from the eNB over the frequency channel of the shared frequency band; determining acknowledgement/negative acknowledgement, ACK/NACK, information for the data transmission; and transmitting the ACK/NACK information in a CCA-exempt feedback transmission to the eNB via the frequency channel of the shared frequency band, wherein the ACK/NACK information is mapped to designated resources of an uplink control channel structure for the CCA-exempt feedback transmission and characterized in that the start of the CCA-exempt feedback transmission occurs less than a predetermined CCA time period from the end of the DL data transmission.
Control valve arrangement of a fuel injector comprising a valve housing wherein are arranged a filling channel extending from a high pressure fuel supply line to a filling chamber that is in a first fluid communication with a first control chamber, said first fluid communication being controlled by a filling valve normally biased open, by a first spring, away from a first seat arranged in the valve housing and, a communication channel extending from the first control chamber to a second control chamber that is in a second fluid communication with a low pressure outlet line, said second fluid communication being controlled by a control valve normally biased closed, by a second spring, in complementary abutment against a second seat arranged in the housing, the control valve cooperating with an actuator to commute from the normally closed position to an open position and, a bore in which a piston is slidably arranged, the piston piloting the injection of the fuel into a compression chamber, the bore being in a third fluid communication with the first control chamber, characterized in that the bore directly opens into the first control chamber, said third fluid communication being unrestricted, the volume of the second control chamber being minimal and wherein, the filling valve and the control valve are poppet valves each provided with a stem (44, 60), the two valves (40, 56) being coaxially arranged and in close vicinity, the second control chamber being between the extremity of the filling valve stem and the control valve so that the volume of said second control chamber is minimal.
A method for increasing the secretion yield of a mature protein comprising: (i) providing a polynucleotide that encodes an immature protein comprising an amino acid sequence of a leader sequence and of a mature desired protein; (ii) modifying the polynucleotide sequence to introduce an amino acid sequence motif into the leader sequence; and (iii) allowing the immature protein to be secreted by a fungal host cell to generate a mature protein; wherein: (a) the motif comprises -X 1 -X 2 -X 3 -X 4 -X 5 - where X 1 is phenylalanine, tryptophan, or tyrosine, X 2 is isoleucine, leucine, valine, alanine or methionine, X 3 is leucine, valine, alanine or methionine, X 4 is serine or threonine and X 5 is isoleucine, valine, alanine or methionine; and (b) the secretion yield of the mature protein is increased relative to the secretion yield of a mature protein resulting from an immature protein comprising the leader sequence without the motif. (i) providing a polynucleotide that encodes an immature protein comprising an amino acid sequence of a leader sequence and of a mature desired protein; (ii) modifying the polynucleotide sequence to introduce an amino acid sequence motif into the leader sequence; and (iii) allowing the immature protein to be secreted by a fungal host cell to generate a mature protein; wherein: (a) the motif comprises -X 1 -X 2 -X 3 -X 4 -X 5 - where X 1 is phenylalanine, tryptophan, or tyrosine, X 2 is isoleucine, leucine, valine, alanine or methionine, X 3 is leucine, valine, alanine or methionine, X 4 is serine or threonine and X 5 is isoleucine, valine, alanine or methionine; and (b) the secretion yield of the mature protein is increased relative to the secretion yield of a mature protein resulting from an immature protein comprising the leader sequence without the motif. (a) the motif comprises -X 1 -X 2 -X 3 -X 4 -X 5 - where X 1 is phenylalanine, tryptophan, or tyrosine, X 2 is isoleucine, leucine, valine, alanine or methionine, X 3 is leucine, valine, alanine or methionine, X 4 is serine or threonine and X 5 is isoleucine, valine, alanine or methionine; and (b) the secretion yield of the mature protein is increased relative to the secretion yield of a mature protein resulting from an immature protein comprising the leader sequence without the motif.
A pivot bearing for a leaf of a window, a French window or the like, which is pivotable relative to a frame, having a bearing fork part having two fork legs (6, 106, 206), having a bearing pin, and having a securing element (7, 107, 207) for axially securing the bearing bin to one of the two fork legs (6, 106, 206), wherein the securing element (7, 107, 207) has a basic element (9, 109, 209) arranged in the one of the two fork legs (6, 106, 206) and a spring element (10, 110, 210) and that the basic element (9, 109, 209) and the spring element (10, 110, 210) are designed as separate components, characterized in that the one of the two fork legs (6, 106, 206) is designed bow-shaped, engaging over the basic element (9, 109, 209) in such a manner that the basic element is supported in the radial direction when viewed from the bearing pin, that the basic element (9, 109, 209) has a shell for the bearing pin, that the spring element (10, 110, 210) connects the one of the two fork legs (6, 106, 206) to the basic element (9, 109, 209) and the bearing pin and that the basic element (9, 109, 209) has a recess (14, 114, 214) for accommodating the spring element (10, 110, 210).