A glucose monitoring system comprising: a glucose sensor configured to be positioned at least in part in contact with interstitial fluid in a body of a user; a transmitter unit configured to process data indicative of a plurality of monitored glucose levels from the glucose sensor; and a receiver unit (104, 200) comprising a processor, and a user interface having a display and an actuator, wherein the receiver unit (104, 200) is configured to receive the processed data from the transmitter unit, wherein the display is configured to render a plurality of display screens, including at least a home screen (300, 390) and an alert screen (1900, 2000, 2100), wherein the home screen (300, 390) is divided into a plurality of simultaneously displayed panels, wherein a first panel (302, 303) of the plurality of panels is configured to display the plurality of monitored glucose levels, wherein a second panel (320, 360) of the plurality of panels is configured to simultaneously display a current glucose level and a glucose trend indicator, and wherein a third panel of the plurality of panels is configured to display status information (330, 332, 334, 336) of a plurality of components of the receiver unit (104, 200); wherein the display is further configured to: render the alert screen (1900, 2000, 2100) in place of one of the first panel (302, 303), the second panel (320, 360), or the third panel of the home screen (300, 390) and not in place of the remaining panels out of the first panel (302, 303), the second panel (320, 360), and the third panel of the home screen (300, 390) when an alarm condition is detected, the alert screen (1900, 2000, 2100) having information (1920, 2020, 2120) corresponding to the detected alarm condition, and to affect a further output of the glucose monitoring system corresponding to the detected alarm condition in response to user actuation of the actuator; and wherein the processor is configured to cause the display to render the plurality of display screens. a glucose sensor configured to be positioned at least in part in contact with interstitial fluid in a body of a user; a transmitter unit configured to process data indicative of a plurality of monitored glucose levels from the glucose sensor; and a receiver unit (104, 200) comprising a processor, and a user interface having a display and an actuator, wherein the receiver unit (104, 200) is configured to receive the processed data from the transmitter unit, wherein the display is configured to render a plurality of display screens, including at least a home screen (300, 390) and an alert screen (1900, 2000, 2100), wherein the home screen (300, 390) is divided into a plurality of simultaneously displayed panels, wherein a first panel (302, 303) of the plurality of panels is configured to display the plurality of monitored glucose levels, wherein a second panel (320, 360) of the plurality of panels is configured to simultaneously display a current glucose level and a glucose trend indicator, and wherein a third panel of the plurality of panels is configured to display status information (330, 332, 334, 336) of a plurality of components of the receiver unit (104, 200); wherein the display is further configured to: render the alert screen (1900, 2000, 2100) in place of one of the first panel (302, 303), the second panel (320, 360), or the third panel of the home screen (300, 390) and not in place of the remaining panels out of the first panel (302, 303), the second panel (320, 360), and the third panel of the home screen (300, 390) when an alarm condition is detected, the alert screen (1900, 2000, 2100) having information (1920, 2020, 2120) corresponding to the detected alarm condition, and to affect a further output of the glucose monitoring system corresponding to the detected alarm condition in response to user actuation of the actuator; render the alert screen (1900, 2000, 2100) in place of one of the first panel (302, 303), the second panel (320, 360), or the third panel of the home screen (300, 390) and not in place of the remaining panels out of the first panel (302, 303), the second panel (320, 360), and the third panel of the home screen (300, 390) when an alarm condition is detected, the alert screen (1900, 2000, 2100) having information (1920, 2020, 2120) corresponding to the detected alarm condition, and to affect a further output of the glucose monitoring system corresponding to the detected alarm condition in response to user actuation of the actuator; and wherein the processor is configured to cause the display to render the plurality of display screens.