An immunomodulatory peptide construct having the formula P 1- x-P 2 or P 2 -x-P 1 where P 1 is a peptide associated with rheumatoid arthritis selected from the group consisting of SEQ ID NOs: 836, 837, and 838, which binds to an antigen receptor on a set or subset of T cells; P 2 is a peptide which will cause a T h 2 directed immune response by said set or subset of T cells to which the peptide P 1 is attached or which will bind to a T cell receptor which will cause said set or subset of T cells to which the peptide P 1 is attached to initiate, but not complete, an immune response causing said set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P 1 and P 2, wherein X 1 is selected from the group consisting of Ala and Gly, X 2 is selected from the group consisting of Asp and Glu, X 3 is selected from the group consisting of Ile, Leu and Val, X 4 is selected from the group consisting of Lys, Arg and His, X 5 is selected from the group consisting of Cys and Ser, X 6 is selected from the group consisting of Phe, Trp and Tyr, X 7 is selected from the group consisting of Phe and Pro, X 8 is selected from the group consisting of Met and Nle, X 9 is selected from the group consisting of Asn and Gln, X 10 is selected from the group consisting of Thr and Ser, X 11 is Gaba where X 2 X 3, X 3 X 2, X 2 X 3, X 3 X 2, X 3 X 3, or X 2 X 2 can be substituted with X 11, X 12 is selected from the group consisting of acetyl, propionyl group, D glycine, D alanine and cyclohexylalanine, X 13 is 5-aminopentanoic where any combination of 3 to 4 amino acids of X 2 and X 3 can be replaced with X 13, X 14 is selected from the group consisting of X 1, X 2, X 3, X 4, X 5, X 6, X 7, X 8, X 9 and X 10, and X 15 is selected from the group consisting of X 1 X 1, X 1 X 3, X 3 X 1, X 1 X 2 and X 2 X 1. P 1 is a peptide associated with rheumatoid arthritis selected from the group consisting of SEQ ID NOs: 836, 837, and 838, which binds to an antigen receptor on a set or subset of T cells; P 2 is a peptide which will cause a T h 2 directed immune response by said set or subset of T cells to which the peptide P 1 is attached or which will bind to a T cell receptor which will cause said set or subset of T cells to which the peptide P 1 is attached to initiate, but not complete, an immune response causing said set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P 1 and P 2, wherein X 1 is selected from the group consisting of Ala and Gly, X 2 is selected from the group consisting of Asp and Glu, X 3 is selected from the group consisting of Ile, Leu and Val, X 4 is selected from the group consisting of Lys, Arg and His, X 5 is selected from the group consisting of Cys and Ser, X 6 is selected from the group consisting of Phe, Trp and Tyr, X 7 is selected from the group consisting of Phe and Pro, X 8 is selected from the group consisting of Met and Nle, X 9 is selected from the group consisting of Asn and Gln, X 10 is selected from the group consisting of Thr and Ser, X 11 is Gaba where X 2 X 3, X 3 X 2, X 2 X 3, X 3 X 2, X 3 X 3, or X 2 X 2 can be substituted with X 11, X 12 is selected from the group consisting of acetyl, propionyl group, D glycine, D alanine and cyclohexylalanine, X 13 is 5-aminopentanoic where any combination of 3 to 4 amino acids of X 2 and X 3 can be replaced with X 13, X 14 is selected from the group consisting of X 1, X 2, X 3, X 4, X 5, X 6, X 7, X 8, X 9 and X 10, and X 15 is selected from the group consisting of X 1 X 1, X 1 X 3, X 3 X 1, X 1 X 2 and X 2 X 1.