A system for controlling fluid flow to a patient through a fluid pathway comprising: a fluid port comprising: a fluid channel; a fluid inlet at a first end of the fluid channel configured to couple to an outlet of a manually administrable fluid source; a fluid outlet at a second end of the fluid channel configured to deliver fluid from the manually administrable fluid source to a fluid pathway (202, 204, 206) that provides fluid to a patient; at least one sensor (145, 148) configured to determine at least one attribute of the fluid from the manually administrable fluid source; a flow controller (125, 130) in communication with the at least one sensor that generates at least one flow modification signal in response to the determined at least one attribute matching at least one condition specified by at least one rule; and a flow control valve in communication with the flow controller and positioned within the fluid pathway at a location separate and distinct from the fluid port, the flow control valve changing a level of flow restriction of the fluid from the manually administrable fluid source passing therethrough in response to receiving the at least one flow modification signal, wherein changing a level of flow restriction of the fluid from the manually administrable fluid source passing through the flow control valve comprises adjusting a current flow rate of the fluid passing through the flow control valve to a higher or lower flow rate, wherein the flow control valve partially restricts the fluid passing through the flow control valve at the higher or lower rate; and wherein the at least one sensor is configured to automatically measure a withdrawn downstream fluid volume, wherein the withdrawn downstream fluid volume is a total volume of the fluid downstream of the fluid inlet and still within the fluid channel after fluid flow through the fluid pathway is stopped. a fluid port comprising: a fluid channel; a fluid inlet at a first end of the fluid channel configured to couple to an outlet of a manually administrable fluid source; a fluid outlet at a second end of the fluid channel configured to deliver fluid from the manually administrable fluid source to a fluid pathway (202, 204, 206) that provides fluid to a patient; at least one sensor (145, 148) configured to determine at least one attribute of the fluid from the manually administrable fluid source; a flow controller (125, 130) in communication with the at least one sensor that generates at least one flow modification signal in response to the determined at least one attribute matching at least one condition specified by at least one rule; and a flow control valve in communication with the flow controller and positioned within the fluid pathway at a location separate and distinct from the fluid port, the flow control valve changing a level of flow restriction of the fluid from the manually administrable fluid source passing therethrough in response to receiving the at least one flow modification signal, wherein changing a level of flow restriction of the fluid from the manually administrable fluid source passing through the flow control valve comprises adjusting a current flow rate of the fluid passing through the flow control valve to a higher or lower flow rate, wherein the flow control valve partially restricts the fluid passing through the flow control valve at the higher or lower rate; and wherein the at least one sensor is configured to automatically measure a withdrawn downstream fluid volume, wherein the withdrawn downstream fluid volume is a total volume of the fluid downstream of the fluid inlet and still within the fluid channel after fluid flow through the fluid pathway is stopped. a fluid channel; a fluid inlet at a first end of the fluid channel configured to couple to an outlet of a manually administrable fluid source; a fluid outlet at a second end of the fluid channel configured to deliver fluid from the manually administrable fluid source to a fluid pathway (202, 204, 206) that provides fluid to a patient; at least one sensor (145, 148) configured to determine at least one attribute of the fluid from the manually administrable fluid source; a flow controller (125, 130) in communication with the at least one sensor that generates at least one flow modification signal in response to the determined at least one attribute matching at least one condition specified by at least one rule; and a flow control valve in communication with the flow controller and positioned within the fluid pathway at a location separate and distinct from the fluid port, the flow control valve changing a level of flow restriction of the fluid from the manually administrable fluid source passing therethrough in response to receiving the at least one flow modification signal, wherein changing a level of flow restriction of the fluid from the manually administrable fluid source passing through the flow control valve comprises adjusting a current flow rate of the fluid passing through the flow control valve to a higher or lower flow rate, wherein the flow control valve partially restricts the fluid passing through the flow control valve at the higher or lower rate; and wherein the at least one sensor is configured to automatically measure a withdrawn downstream fluid volume, wherein the withdrawn downstream fluid volume is a total volume of the fluid downstream of the fluid inlet and still within the fluid channel after fluid flow through the fluid pathway is stopped.