A peristaltic pump system comprising: a length of tubing having first and second ends (110, 112), the tubing having an outer diameter d o, a first tube collar fixedly attached to the tubing at a first position between the first and second ends (110, 112) and extending outwardly of the outer diameter d o, and a second tube collar fixedly attached to the tubing at a second position spaced from the first position between the first and second ends (110, 112),and extending outwardly of the outer diameter d o; a rotary peristaltic pump with an arcuate tube channel having a first end and a second end, the length of tubing disposed in the arcuate tube channel, and a rotor configured to contact the length of tubing disposed in the arcuate tube channel to move fluid through the length of tubing; and a first tube guide disposed at the first end of the tube channel and a second tube guide disposed at the second end of the tube channel, the first and second tube guides (106, 108) each comprising a passage (150, 250) therethrough with an inner diameter d i that is larger than the outer diameter d o of the tubing, and an opening (152, 252) in communication with the passage (150, 250) through which the length of tubing is disposed into the passage (150, 250), the first tube guide having an unrestricted shoulder configured to abut the first tube collar with the length of tubing in the arcuate tube channel in an installation state, and the second tube guide having an unrestricted shoulder configured to abut the second tube collar with the length of tubing in the arcuate tube channel in the installation state, and the passage of the first tube guide is disposed between the unrestricted shoulder of the first tube guide and the first end of the arcuate tube channel, and the passage of the second tube guide is disposed between the unrestricted shoulder of the second tube guide and the second end of the arcuate tube channel, wherein: the first tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end, and the second tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end. a length of tubing having first and second ends (110, 112), the tubing having an outer diameter d o, a first tube collar fixedly attached to the tubing at a first position between the first and second ends (110, 112) and extending outwardly of the outer diameter d o, and a second tube collar fixedly attached to the tubing at a second position spaced from the first position between the first and second ends (110, 112),and extending outwardly of the outer diameter d o; a rotary peristaltic pump with an arcuate tube channel having a first end and a second end, the length of tubing disposed in the arcuate tube channel, and a rotor configured to contact the length of tubing disposed in the arcuate tube channel to move fluid through the length of tubing; and a first tube guide disposed at the first end of the tube channel and a second tube guide disposed at the second end of the tube channel, the first and second tube guides (106, 108) each comprising a passage (150, 250) therethrough with an inner diameter d i that is larger than the outer diameter d o of the tubing, and an opening (152, 252) in communication with the passage (150, 250) through which the length of tubing is disposed into the passage (150, 250), the first tube guide having an unrestricted shoulder configured to abut the first tube collar with the length of tubing in the arcuate tube channel in an installation state, and the second tube guide having an unrestricted shoulder configured to abut the second tube collar with the length of tubing in the arcuate tube channel in the installation state, and the passage of the first tube guide is disposed between the unrestricted shoulder of the first tube guide and the first end of the arcuate tube channel, and the passage of the second tube guide is disposed between the unrestricted shoulder of the second tube guide and the second end of the arcuate tube channel, wherein: the first tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end, and the second tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end. the first tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end, and the second tube guide comprises another passage with an inner diameter D i that is larger than the inner diameter d i of the passage, the another passage having a first end connected to the passage and a second end.