A compound represented by formula 1 below, an optical isomer thereof, a solvate thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof: wherein, R 1 is hydrogen or C1-10 alkyl; containing R 2 can form or R 6 is hydrogen or tert-butoxycarbonyl; R 3 is R 7a, R 7b, R 7c and R 7d are independently hydrogen, NH 2 or methyl;R 4 is hydrogen, C 3-10 cycloalkyl, C 6-10 aryl or 3-10 membered heterocycloalkyl or 5-13 membered heteroaryl; L 1 is L 2 is - X-, - y -O-, - z-N(R a)-, -CH(C(R b) 3)-O-, or wherein x is an integer of 0 to 4, y is an integer of 0 to 4, z is an integer of 0 to 4, R a is hydrogen or C 1-6 alkyl, R b is hydrogen or halogen; wherein the said alkyl, aryl, cycloalkyl, heterocycloalkyl and heteroaryl can be independently substituted with one or more substituents selected form the group consisting of halogen; NH 2; hydroxy; C 1-6 alkyl; C 1-6 alkoxy; C 6-10 aryl; hydroxyl C 1-6 alkyl; hydroxyl C 1-6 alkoxy; hydroxyl C 6-10 aryl; halo C 1-6 alkyl; halo C 1-6 alkoxy; halo C 6-10 aryl; C 1-6 alkyl C 6-10 aryl; C 1-6, alkoxy C 6-10 aryl; C 1-6 alkylcarbonyl; C 1-6 alkoxycarbonyl; halo C 3-10 cycloalkenyl; halo C 1-6 alkoxy C 6-10 aryl; C 3-10 cycloalkyl C 1-6 alkoxy C 6-10 aryl; hydroxyl C 1-6 alkyl C 6-10 aryl; 5-13 membered heteroaryl; fused rings containing halophenyl, pyridine and C 5-7 cycloalkyl; C 1-6 alkyl 5-13 membered heteroaryl; 3-10 memberedheterocycloalkenyl; and C 1-6 alkyl 3-10 membered heterocycloalkenyl, and the substituent can be bound to alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl by single bonds or double bonds; the said heteroaryl, heterocycloalkyl and heterocycloalkenyl independently include one or more hetero atoms selected from the group consisting of N, O and S; and alkyl or alkoxy can have a straight or branched form. R 1 is hydrogen or C1-10 alkyl; containing R 2 can form or R 6 is hydrogen or tert-butoxycarbonyl; R 3 is R 7a, R 7b, R 7c and R 7d are independently hydrogen, NH 2 or methyl;R 4 is hydrogen, C 3-10 cycloalkyl, C 6-10 aryl or 3-10 membered heterocycloalkyl or 5-13 membered heteroaryl; L 1 is L 2 is - X-, - y -O-, - z-N(R a)-, -CH(C(R b) 3)-O-, or wherein x is an integer of 0 to 4, y is an integer of 0 to 4, z is an integer of 0 to 4, R a is hydrogen or C 1-6 alkyl, R b is hydrogen or halogen; wherein the said alkyl, aryl, cycloalkyl, heterocycloalkyl and heteroaryl can be independently substituted with one or more substituents selected form the group consisting of halogen; NH 2; hydroxy; C 1-6 alkyl; C 1-6 alkoxy; C 6-10 aryl; hydroxyl C 1-6 alkyl; hydroxyl C 1-6 alkoxy; hydroxyl C 6-10 aryl; halo C 1-6 alkyl; halo C 1-6 alkoxy; halo C 6-10 aryl; C 1-6 alkyl C 6-10 aryl; C 1-6, alkoxy C 6-10 aryl; C 1-6 alkylcarbonyl; C 1-6 alkoxycarbonyl; halo C 3-10 cycloalkenyl; halo C 1-6 alkoxy C 6-10 aryl; C 3-10 cycloalkyl C 1-6 alkoxy C 6-10 aryl; hydroxyl C 1-6 alkyl C 6-10 aryl; 5-13 membered heteroaryl; fused rings containing halophenyl, pyridine and C 5-7 cycloalkyl; C 1-6 alkyl 5-13 membered heteroaryl; 3-10 memberedheterocycloalkenyl; and C 1-6 alkyl 3-10 membered heterocycloalkenyl, and the substituent can be bound to alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl by single bonds or double bonds; the said heteroaryl, heterocycloalkyl and heterocycloalkenyl independently include one or more hetero atoms selected from the group consisting of N, O and S; and alkyl or alkoxy can have a straight or branched form.