A compound of Formula A: having the structure of (i) wherein Het/Ar is C 6 -C 10 aryl, or a 5-10-membered heteroaryl having 1-3 ring heteroatoms selected from N, O, and S; and L is C 1 -C 14 alkyl-OC NH-C 1 -C 14 alkyl-R z; R z is H, C 1 -C 6 alkyl, or C 1 -C 6 alkyl-CO 2 R 5, and the alkyl is optionally substituted with one or more of hydroxy, halogen, C 1 -C 6 -alkoxy, C 1 -C 6 haloalkoxy, NH 2, -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl) 2, -OCO(C 1 -C 4 alkyl), -CO-C 1 -C 4 alkyl, -CO 2 H, and -CO 2 C 1 -C 4 alkyl; each R 5 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkoxy, C 2 -C 8 alkoxy-C 6 -C 10 aryl, CO 2 H, CO 2 -C 1 -C 6 alkyl, CONH 2, CONH-C 1 -C 6 alkyl, CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-CO 2 H, C 1 -C 6 alkyl-CO 2 -C 1 -C 6 alkyl, C 1 -C 6 alkyl-CONH 2, C 1 -C 6 alkyl-CONH(C 1 -C 6 alkyl), C 1 -C 6 alkyl-CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-C 6 -C 10 aryl, 5-10 membered heteroaryl, or C 1 -C 6 alkyl-5-10 membered heteroaryl, wherein said heteroaryl comprises 1-3 ring heteroatoms selected from O, N, and S; or (ii) wherein R" is -H or C 1 -C 6 alkyl optionally substituted with one or moresubstituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 aminoalkoxy, C 1 -C 6 cyanoalkoxy, C 1 -C 6 hydroxyalkoxy and C 2 -C 6 alkoxyalkoxy, or a pharmaceutically acceptable salt thereof. (i) wherein Het/Ar is C 6 -C 10 aryl, or a 5-10-membered heteroaryl having 1-3 ring heteroatoms selected from N, O, and S; and L is C 1 -C 14 alkyl-OC NH-C 1 -C 14 alkyl-R z; R z is H, C 1 -C 6 alkyl, or C 1 -C 6 alkyl-CO 2 R 5, and the alkyl is optionally substituted with one or more of hydroxy, halogen, C 1 -C 6 -alkoxy, C 1 -C 6 haloalkoxy, NH 2, -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl) 2, -OCO(C 1 -C 4 alkyl), -CO-C 1 -C 4 alkyl, -CO 2 H, and -CO 2 C 1 -C 4 alkyl; each R 5 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkoxy, C 2 -C 8 alkoxy-C 6 -C 10 aryl, CO 2 H, CO 2 -C 1 -C 6 alkyl, CONH 2, CONH-C 1 -C 6 alkyl, CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-CO 2 H, C 1 -C 6 alkyl-CO 2 -C 1 -C 6 alkyl, C 1 -C 6 alkyl-CONH 2, C 1 -C 6 alkyl-CONH(C 1 -C 6 alkyl), C 1 -C 6 alkyl-CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-C 6 -C 10 aryl, 5-10 membered heteroaryl, or C 1 -C 6 alkyl-5-10 membered heteroaryl, wherein said heteroaryl comprises 1-3 ring heteroatoms selected from O, N, and S; or Het/Ar is C 6 -C 10 aryl, or a 5-10-membered heteroaryl having 1-3 ring heteroatoms selected from N, O, and S; and L is C 1 -C 14 alkyl-OC NH-C 1 -C 14 alkyl-R z; R z is H, C 1 -C 6 alkyl, or C 1 -C 6 alkyl-CO 2 R 5, and the alkyl is optionally substituted with one or more of hydroxy, halogen, C 1 -C 6 -alkoxy, C 1 -C 6 haloalkoxy, NH 2, -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl) 2, -OCO(C 1 -C 4 alkyl), -CO-C 1 -C 4 alkyl, -CO 2 H, and -CO 2 C 1 -C 4 alkyl; each R 5 is independently H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkoxy, C 2 -C 8 alkoxy-C 6 -C 10 aryl, CO 2 H, CO 2 -C 1 -C 6 alkyl, CONH 2, CONH-C 1 -C 6 alkyl, CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-CO 2 H, C 1 -C 6 alkyl-CO 2 -C 1 -C 6 alkyl, C 1 -C 6 alkyl-CONH 2, C 1 -C 6 alkyl-CONH(C 1 -C 6 alkyl), C 1 -C 6 alkyl-CON(C 1 -C 6 alkyl) 2, C 1 -C 6 alkyl-C 6 -C 10 aryl, 5-10 membered heteroaryl, or C 1 -C 6 alkyl-5-10 membered heteroaryl, wherein said heteroaryl comprises 1-3 ring heteroatoms selected from O, N, and S; or (ii) wherein R" is -H or C 1 -C 6 alkyl optionally substituted with one or moresubstituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 aminoalkoxy, C 1 -C 6 cyanoalkoxy, C 1 -C 6 hydroxyalkoxy and C 2 -C 6 alkoxyalkoxy,