A compound of Formula: or a tautomer or a pharmaceutically acceptable salt thereof, wherein G 1 is N and G 2 is N; L 1 is NH; Z 1 is phenyl optionally substituted with 1 to 5 R 1; R 1 is independently selected from the group consisting of halo, C 1-8 alkyl, C 2-8 alkenyl, haloC 1-8 alkyl, (CH 2) n SR 1a, (CH 2) n OR 1a, O(CH 2) j OR 1a, (CH 2) n NR 1b R 1c, (CH 2) n COR 1e, (CH 2) n CONR 1b R 1c, (CH 2) n NR 1b COR 1e, (CH 2) n CONR 1b (OR 1a), (CH 2) n CO 2 R 1a, O(CH 2) n CO 2 R 1a, (CH 2) n NR 1b CO 2 R 1a, n SO 2 NR 1b R 1c, (CH 2) n NR 1b SO 2 R 1e, (CH 2) n SOR 1e, (CH 2) n SO 2 R 1e, oxo, (CH 2) n CN, N 3, NO 2, and -L 2 -W, where n is 0, 1, 2, 3, 4, 5, or 6 and j is 1, 2, 3, 4, 5, or 6; L 2 is selected from the group consisting of -O(CH 2) b -, -SO-, -SO 2 - -CO-, -NR 1d -, -CONR 1d (CH 2) b -, -NR 1d CO-, -NR 1d SO 2 -, -SO 2 NR 1d -, a bond, and -(CH 2) e - where b is 0, 1, 2, 3, 4, or 5 and e is 1, 2, 3, 4, or 5; W is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocyclyl each optionally substituted with 1 to 3 R 2; R 2 is independently selected from the group consisting of halo, C 1-8 alkyl, C 2-8 alkenyl, haloC 1-8 alkyl, (CH 2) m SR 2a, (CH 2) m OR 2a, O(CH 2) k OR 2a, (CH 2) m NR 2b R 2c, (CH 2) m COR 2e, (CH 2) m CONR 2b R 2c, (CH 2) m NR 2b COR 2e, (CH 2) m CONR 2b (OR 2a), (CH 2) m CO 2 R 2a, O(CH 2) m CO 2 R 2a, (CH 2) m NR 2b CO 2 R 2a, m SO 2 NR 2b R 2c, (CH 2) m NR 2b SO 2 R 2e, (CH 2) m SOR 2e, (CH 2) m SO 2 R 2e, oxo, (CH 2) m CN, N 3, and NO 2, where m is 0, 1, 2, 3, 4, 5, or 6 and k is 1, 2, 3, 4, 5, or 6; R 1a, R 1b, R 1c,, R 1d R 2a, R 2b, and R 2c are independently selected from the group consisting of H, C 1-8 alkyl, C 2-8 alkenyl, and haloC 1-8 alkyl; R 1e and R 2e are independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and haloC 1-8 alkyl; Y 1 is optionally substituted with 1 to 2 halo substituents; and the wavy line indicates the point of attachment to the rest of the molecule. G 1 is N and G 2 is N; L 1 is NH; Z 1 is phenyl optionally substituted with 1 to 5 R 1; R 1 is independently selected from the group consisting of halo, C 1-8 alkyl, C 2-8 alkenyl, haloC 1-8 alkyl, (CH 2) n SR 1a, (CH 2) n OR 1a, O(CH 2) j OR 1a, (CH 2) n NR 1b R 1c, (CH 2) n COR 1e, (CH 2) n CONR 1b R 1c, (CH 2) n NR 1b COR 1e, (CH 2) n CONR 1b (OR 1a), (CH 2) n CO 2 R 1a, O(CH 2) n CO 2 R 1a, (CH 2) n NR 1b CO 2 R 1a, n SO 2 NR 1b R 1c, (CH 2) n NR 1b SO 2 R 1e, (CH 2) n SOR 1e, (CH 2) n SO 2 R 1e, oxo, (CH 2) n CN, N 3, NO 2, and -L 2 -W, where n is 0, 1, 2, 3, 4, 5, or 6 and j is 1, 2, 3, 4, 5, or 6; L 2 is selected from the group consisting of -O(CH 2) b -, -SO-, -SO 2 - -CO-, -NR 1d -, -CONR 1d (CH 2) b -, -NR 1d CO-, -NR 1d SO 2 -, -SO 2 NR 1d -, a bond, and -(CH 2) e - where b is 0, 1, 2, 3, 4, or 5 and e is 1, 2, 3, 4, or 5; W is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocyclyl each optionally substituted with 1 to 3 R 2; R 2 is independently selected from the group consisting of halo, C 1-8 alkyl, C 2-8 alkenyl, haloC 1-8 alkyl, (CH 2) m SR 2a, (CH 2) m OR 2a, O(CH 2) k OR 2a, (CH 2) m NR 2b R 2c, (CH 2) m COR 2e, (CH 2) m CONR 2b R 2c, (CH 2) m NR 2b COR 2e, (CH 2) m CONR 2b (OR 2a), (CH 2) m CO 2 R 2a, O(CH 2) m CO 2 R 2a, (CH 2) m NR 2b CO 2 R 2a, m SO 2 NR 2b R 2c, (CH 2) m NR 2b SO 2 R 2e, (CH 2) m SOR 2e, (CH 2) m SO 2 R 2e, oxo, (CH 2) m CN, N 3, and NO 2, where m is 0, 1, 2, 3, 4, 5, or 6 and k is 1, 2, 3, 4, 5, or 6; R 1a, R 1b, R 1c,, R 1d R 2a, R 2b, and R 2c are independently selected from the group consisting of H, C 1-8 alkyl, C 2-8 alkenyl, and haloC 1-8 alkyl; R 1e and R 2e are independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and haloC 1-8 alkyl; Y 1 is