A pulse diagnosis measurement device, comprising: a sensing device, configured to sense a blood pressure wave of an organism, to generate a pulse signal; a pulse-holding device, configured to apply a pressure on a pulse of the organism to facilitate the sensing device to sense the blood pressure wave; and a processing device; wherein the pulse-holding device has a first elasticity coefficient, the first elasticity coefficient is corresponding to a first frequency of a first harmonic of the blood pressure wave, such that the pulse-holding device resonates with the first harmonic to cause the processing device to generate pulse diagnosis information of the first harmonic by processing the pulse signal; characterized in that the first harmonic is a first integer harmonic or a first fractional harmonic; the pulse-holding device comprises a plurality of tourniquets for producing different elasticity coefficients, which include the first elasticity coefficient and a second elasticity coefficient, by being connectable in series or in parallel or by being used separately when the tourniquets have different elasticity coefficients; the second elasticity coefficient is corresponding to a second frequency of a second harmonic of the blood pressure wave, and the second harmonic is a second integer harmonic or a second fractional harmonic; the pulse-holding device is configured for switching from the first elasticity coefficient to the second elasticity coefficient by use of the tourniquets, such that the pulse-holding device resonates with the second harmonic to cause the processing device to generate pulse diagnosis information of the second harmonic by processing the pulse signal; when the second frequency of the second harmonic is greater than the first frequency of the first harmonic, the second elasticity coefficient is greater than the first elasticity coefficient. a sensing device, configured to sense a blood pressure wave of an organism, to generate a pulse signal; a pulse-holding device, configured to apply a pressure on a pulse of the organism to facilitate the sensing device to sense the blood pressure wave; and a processing device; wherein the pulse-holding device has a first elasticity coefficient, the first elasticity coefficient is corresponding to a first frequency of a first harmonic of the blood pressure wave, such that the pulse-holding device resonates with the first harmonic to cause the processing device to generate pulse diagnosis information of the first harmonic by processing the pulse signal; characterized in that the first harmonic is a first integer harmonic or a first fractional harmonic; the pulse-holding device comprises a plurality of tourniquets for producing different elasticity coefficients, which include the first elasticity coefficient and a second elasticity coefficient, by being connectable in series or in parallel or by being used separately when the tourniquets have different elasticity coefficients; the second elasticity coefficient is corresponding to a second frequency of a second harmonic of the blood pressure wave, and the second harmonic is a second integer harmonic or a second fractional harmonic; the pulse-holding device is configured for switching from the first elasticity coefficient to the second elasticity coefficient by use of the tourniquets, such that the pulse-holding device resonates with the second harmonic to cause the processing device to generate pulse diagnosis information of the second harmonic by processing the pulse signal; when the second frequency of the second harmonic is greater than the first frequency of the first harmonic, the second elasticity coefficient is greater than the first elasticity coefficient.