A compound of Formula wherein D is N, CH, or CF; R 1 is (C 1 -C 4)alkyl optionally substituted with one, two or three substituents each independently selected from fluoro and (C 3 -C 6)cycloalkyl; R 2 is fluoro or (C 1 -C 4)alkyl; R 3 is H, (C 1 -C 4)alkyl, or (C 3 -C 6)cycloalkyl; R 4 is H, -(C 1 -C 4)alkyl, -((C 1 -C 4)alkyl) p -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) p -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) p -aryl, or -((C 1 -C 4)alkyl) p -heteroaryl wherein R 4 is optionally substituted with one, two, three, or four substituents selected from halo, cyano, oxo, aminyl, iminyl, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)fluoroalkyl, -(C 1 -C 4)alkoxy, - (C 3 -C 6)cycloalkoxy, -(C 1 -C 4)fluoroalkoxy, -((C 1 -C 4)alkyl) q -COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl-COOH, -((C 1 -C 4)alkyl) q -aryl-COOH, -((C 1 -C 4)alkyl) q -heteroaryl-COOH, -O-((C 1 -C 4)alkyl) q -COOH, -O-((C 1 -C 4)alkyl) q -aryl-COOH, -O-((C 1 -C 4)alkyl) q -heteroaryl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) q -aryl, -((C 1 -C 4)alkyl) q -heteroaryl, -C -(C 1 -C 4)alkyl, -C -(C 1 -C 4)alkoxy, -C -(C 3 -C 6)cycloalkyl, -C -(C 3 -C 6)heterocyclyl, -C -NR 6 R 7, -C -((C 1 -C 4)alkyl) q -aryl, - C -((C 1 -C 4)alkyl) q -heteroaryl, -NR 6 R 7, -NR 6 -C -R 7,-((C 1 -C 4)alkyl) q -O-aryl, -((C 1 -C 4)alkyl) q -O-heteroaryl, -S 2 -R 7, and -S 2 -NR 6 R 7; or R 3 and R 4 may be joined together to form a 4- to 10- member fully saturated, or partially saturated ring system optionally substituted with one, two, three, or four substituents selected from halo, cyano, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)fluoroalkyl, -(C 1 -C 4)alkoxy, -(C 3 -C 6)cycloalkoxy, -(C 1 -C 4)fluoroalkoxy, -((C 1 -C 4)alkyl) q -COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl-COOH, - ((C 1 -C 4)alkyl) q -aryl-COOH, -((C 1 -C 4)alkyl) q -heteroaryl-COOH, -O-((C 1 -C 4)alkyl) q -COOH, -O-((C 1 -C 4)alkyl) q -aryl-COOH, -O-((C 1 -C 4)alkyl) q -heteroaryl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) q -aryl, -((C 1 -C 4)alkyl) q -heteroaryl, -C -(C 1 -C 4)alkyl, -C -(C 3 -C 6)cycloalkyl, -C -(C 3 -C 6)heterocyclyl, -C -aryl, -C - heteroaryl, -C -NR 6 R 7, -C -(C 1 -C 4)alkyl-aryl, -C -(C 1 -C 4)alkyl-heteroaryl, -NR 6 R 7, -NR 6 -C -R 7,-O-aryl, -O-heteroaryl,-(C 1 -C 4)alkyl-O-aryl, -(C 1 -C 4)alkyl-O-heteroaryl, -O-(C 1 -C 4)alkyl-aryl, and -O-(C 1 -C 4)alkyl-heteroaryl; R 5 is H, F, or cyano; R 6 is H, (C 1 -C 4)alkyl, or -S 2 -R 7; R 7 is H, (C 1 -C 4)alkyl, -(C 3 -C 6)cycloalkyl, -(C 3 -C 6)heterocyclyl, aryl, or heteroaryl; n is 0, 1, 2 or 3; p is 0 or 1; and q is 0 or 1; or a pharmaceutically acceptable salt thereof. D is N, CH, or CF; R 1 is (C 1 -C 4)alkyl optionally substituted with one, two or three substituents each independently selected from fluoro and (C 3 -C 6)cycloalkyl; R 2 is fluoro or (C 1 -C 4)alkyl; R 3 is H, (C 1 -C 4)alkyl, or (C 3 -C 6)cycloalkyl; R 4 is H, -(C 1 -C 4)alkyl, -((C 1 -C 4)alkyl) p -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) p -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) p -aryl, or -((C 1 -C 4)alkyl) p -heteroaryl wherein R 4 is optionally substituted with one, two, three, or four substituents selected from halo, cyano, oxo, aminyl, iminyl, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)fluoroalkyl, -(C 1 -C 4)alkoxy, - (C 3 -C 6)cycloalkoxy, -(C 1 -C 4)fluoroalkoxy, -((C 1 -C 4)alkyl) q -COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl-COOH, -((C 1 -C 4)alkyl) q -aryl-COOH, -((C 1 -C 4)alkyl) q -heteroaryl-COOH, -O-((C 1 -C 4)alkyl) q -COOH, -O-((C 1 -C 4)alkyl) q -aryl-COOH, -O-((C 1 -C 4)alkyl) q -heteroaryl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) q -aryl, -((C 1 -C 4)alkyl) q -heteroaryl, -C -(C 1 -C 4)alkyl, -C -(C 1 -C 4)alkoxy, -C -(C 3 -C 6)cycloalkyl, -C -(C 3 -C 6)heterocyclyl, -C -NR 6 R 7, -C -((C 1 -C 4)alkyl) q -aryl, - C -((C 1 -C 4)alkyl) q -heteroaryl, -NR 6 R 7, -NR 6 -C -R 7,-((C 1 -C 4)alkyl) q -O-aryl, -((C 1 -C 4)alkyl) q -O-heteroaryl, -S 2 -R 7, and -S 2 -NR 6 R 7; or R 3 and R 4 may be joined together to form a 4- to 10- member fully saturated, or partially saturated ring system optionally substituted with one, two, three, or four substituents selected from halo, cyano, -OH, -(C 1 -C 4)alkyl, -(C 1 -C 4)fluoroalkyl, -(C 1 -C 4)alkoxy, -(C 3 -C 6)cycloalkoxy, -(C 1 -C 4)fluoroalkoxy, -((C 1 -C 4)alkyl) q -COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl-COOH, - ((C 1 -C 4)alkyl) q -aryl-COOH, -((C 1 -C 4)alkyl) q -heteroaryl-COOH, -O-((C 1 -C 4)alkyl) q -COOH, -O-((C 1 -C 4)alkyl) q -aryl-COOH, -O-((C 1 -C 4)alkyl) q -heteroaryl-COOH, -((C 1 -C 4)alkyl) q -(C 3 -C 6)cycloalkyl, -((C 1 -C 4)alkyl) q -(C 3 -C 6)heterocyclyl, -((C 1 -C 4)alkyl) q -aryl, -((C 1 -C 4)alkyl) q -heteroaryl, -C -(C 1 -C 4)alkyl, -C -(C 3 -C 6)cycloalkyl, -C -(C 3 -C 6)heterocyclyl, -C -aryl, -C - heteroaryl, -C -NR 6 R 7, -C -(C 1 -C 4)alkyl-aryl, -C -(C 1 -C 4)alkyl-heteroaryl, -NR 6 R 7, -NR 6 -C -R 7,-O-aryl, -O-heteroaryl,-(C 1 -C 4)alkyl-O-aryl, -(C 1 -C 4)alkyl-O-heteroaryl, -O-(C 1 -C 4)alkyl-aryl, and -O-(C 1 -C 4)alkyl-heteroaryl; R 5 is H, F, or cyano; R 6 is H, (C 1 -C 4)alkyl, or -S 2 -R 7; R 7 is H, (C 1 -C 4)alkyl, -(C 3 -C 6)cycloalkyl, -(C 3 -C 6)heterocyclyl, aryl, or heteroaryl; n is 0, 1, 2 or 3; p is 0 or 1; and q is 0 or 1;