A system for processing bioprocessing fluids, comprising: a. the system includes a manifold, one or more consumables and at least one non-consumable, each consumable and non-consumable having a predetermined function, wherein the system combines the consumables and the non-consumables, the system being for purifying, filtering or collecting of a bioprocessing fluid; b. at least one of the consumables is a specific consumable characterized by readable tolerance specifications that are embedded within the specific consumable or its packaging and that define suitability of the consumable for use in the system, which readable tolerance specifications are associated with the specific consumable, one of the tolerance specifications being the consumable is a non-genuine consumable for that manifold system, and another of the tolerance specifications being an operational detail, a parameter specification, or combination thereof to define suitability of the particular consumable for its intended use and the environment of such use, c. the non-consumable includes operating logic that controls interrogation of the specific consumable with respect to said readable tolerance specifications thereby determining whether the specific consumable is operating consistent with the readable tolerance specifications; and d. an interlock that activates to inform on non-compliance of the consumable when the operating logic detects operation inconsistent with at least one of the readable tolerance specifications, wherein the interlock activates a stoppage function with respect to the manifold capable of avoiding out-of-compliance operation. a. the system includes a manifold, one or more consumables and at least one non-consumable, each consumable and non-consumable having a predetermined function, wherein the system combines the consumables and the non-consumables, the system being for purifying, filtering or collecting of a bioprocessing fluid; b. at least one of the consumables is a specific consumable characterized by readable tolerance specifications that are embedded within the specific consumable or its packaging and that define suitability of the consumable for use in the system, which readable tolerance specifications are associated with the specific consumable, one of the tolerance specifications being the consumable is a non-genuine consumable for that manifold system, and another of the tolerance specifications being an operational detail, a parameter specification, or combination thereof to define suitability of the particular consumable for its intended use and the environment of such use, c. the non-consumable includes operating logic that controls interrogation of the specific consumable with respect to said readable tolerance specifications thereby determining whether the specific consumable is operating consistent with the readable tolerance specifications; and d. an interlock that activates to inform on non-compliance of the consumable when the operating logic detects operation inconsistent with at least one of the readable tolerance specifications, wherein the interlock activates a stoppage function with respect to the manifold capable of avoiding out-of-compliance operation.