A system for simulating the cardiovascular system of a human or other mammal in which one or more operational parameters are automatically controlled without the need for manual adjustments comprising: a computer based control unit operatively coupled to a closed loop pneumatic feedback circuit configured to generate or move pneumatic fluid through said system and a closed loop hydraulic feedback circuit configured to move hydraulic fluid through said system, said closed looped pneumatic feedback circuit or said closed looped hydraulic feedback circuit is operatively connected to a cardiac system module comprising an atrial actuator and a ventricle actuator; said computer based control unit configured to receive or process data obtained from sensors (134, 136) placed within said system and cause at least one component of said atrial actuator or said ventricle actuator to function based on said data received or processed; at least one sensor (134, 136) placed within said system is configured to detect or respond to changes in one or more parameters of said closed loop pneumatic feedback circuit; and at least one sensor (134, 136) placed within said system is configured to detect or respond to changes in one or more parameters of said closed loop hydraulic feedback circuit; said atrial actuator comprising a rigid outer casing sized and shaped to house a pressurized air delivery device therein and fluidly connected to a flexible, fluid filled inner chamber, said flexible, fluid filled inner chamber constructed and arranged to contract when a pressurized fluid is exerted thereupon, thereby causing said fluid stored within to be ejected out, and expand when said pressurized fluid is removed, and said ventricle actuator comprises an irregularly shaped, flexible ventricle assembly inner member having said fluid stored within and surrounded by a rigid ventricle assembly outer member, said ventricle assembly inner member and said rigid ventricle assembly outer member being separated by a space therebetween, whereby pressurized fluid inserted within said space exerts a force upon said flexible ventricle assembly inner member, causing said flexible ventricle assembly inner member to eject said fluid stored within; said computer based control unit providing physiologically accurate representation of a cardiovasculature system in normal or diseased states whereby one or more operational parameters are automatically controlled without the need for manual adjustments. a computer based control unit operatively coupled to a closed loop pneumatic feedback circuit configured to generate or move pneumatic fluid through said system and a closed loop hydraulic feedback circuit configured to move hydraulic fluid through said system, said closed looped pneumatic feedback circuit or said closed looped hydraulic feedback circuit is operatively connected to a cardiac system module comprising an atrial actuator and a ventricle actuator; said computer based control unit configured to receive or process data obtained from sensors (134, 136) placed within said system and cause at least one component of said atrial actuator or said ventricle actuator to function based on said data received or processed; at least one sensor (134, 136) placed within said system is configured to detect or respond to changes in one or more parameters of said closed loop pneumatic feedback circuit; and at least one sensor (134, 136) placed within said system is configured to detect or respond to changes in one or more parameters of said closed loop hydraulic feedback circuit; said atrial actuator comprising a rigid outer casing sized and shaped to house a pressurized air delivery device therein and fluidly connected to a flexible, fluid filled inner chamber, said flexible, fluid filled inner chamber constructed and arranged to contract when a pressurized fluid is exerted thereupon, thereby causing said fluid stored within to be ejected out, and expand when said pressurized fluid is removed, and said ventricle actuator comprises an irregularly shaped, flexible ventricle assembly inner member having said fluid stored within and surrounded by a rigid ventricle assembly outer member, said ventricle assembly inner member and said rigid ventricle assembly outer member being separated by a space therebetween, whereby pressurized fluid inserted within said space exerts a force upon said flexible ventricle assembly inner member, causing said flexible ventricle assembly inner member to eject said fluid stored within; said computer based control unit providing physiologically accurate representation of a cardiovasculature system in normal or diseased states whereby one or more operational parameters are automatically controlled without the need for manual adjustments.