A complementary metal-oxide-semiconductor (CMOS) imaging system-on-chip (iSoC) sensor system, the sensor system comprising: a pixel array constructed as an array of from two-by-two pixel-structures, the pixel array comprising a first two-by-two pixel structure and a second two-by-two pixel structure, wherein the first two-by-two pixel structure and the second two-by-two pixel structure respectively include four pixels configured to share a floating diffusion region (404, 406); a plurality of read buses (408, 410) respectively associated with columns of two-by-two pixel structures of the pixel array, the plurality of read buses comprising a first read bus associated with the first two-by-two pixel structure so as to carry sampled signals from the floating diffusion region of the first two-by-two pixel structure to a first chain at a top of the chip and/or a second chain at a bottom of the chip, and a second read bus associated with the second two-by-two pixel structure so as to carry sampled signals from the floating diffusion region of the second two-by-two pixel structure to the first chain at the top of the chip and/or a second chain at the bottom of the chip; and a plurality of multiplexers (512, 514) respectively positioned at ends of pairs of read buses, the plurality of read buses comprising a first multiplexer configured to select one of the first read bus or the second read bus from which to transfer a first sampled signal, from one of the first two-by-two pixel structure or the second two-by-two pixel structure, to a first signal chain; and, a second multiplexer configured to select one of the first read bus or the second read bus from which to transfer a second sampled signal to a second signal chain, wherein the second multiplexer selects a disparate read bus from the first multiplexer, wherein the first multiplexer and second multiplexer coordinate selection such that signal information, from the first two-by-two pixel structure and the second two-by-two pixel structure, corresponding to a same color plane are transferred to a same signal chain. a pixel array constructed as an array of from two-by-two pixel-structures, the pixel array comprising a first two-by-two pixel structure and a second two-by-two pixel structure, wherein the first two-by-two pixel structure and the second two-by-two pixel structure respectively include four pixels configured to share a floating diffusion region (404, 406); a plurality of read buses (408, 410) respectively associated with columns of two-by-two pixel structures of the pixel array, the plurality of read buses comprising a first read bus associated with the first two-by-two pixel structure so as to carry sampled signals from the floating diffusion region of the first two-by-two pixel structure to a first chain at a top of the chip and/or a second chain at a bottom of the chip, and a second read bus associated with the second two-by-two pixel structure so as to carry sampled signals from the floating diffusion region of the second two-by-two pixel structure to the first chain at the top of the chip and/or a second chain at the bottom of the chip; and a plurality of multiplexers (512, 514) respectively positioned at ends of pairs of read buses, the plurality of read buses comprising a first multiplexer configured to select one of the first read bus or the second read bus from which to transfer a first sampled signal, from one of the first two-by-two pixel structure or the second two-by-two pixel structure, to a first signal chain; and, a second multiplexer configured to select one of the first read bus or the second read bus from which to transfer a second sampled signal to a second signal chain, wherein the second multiplexer selects a disparate read bus from the first multiplexer, wherein the first multiplexer and second multiplexer coordinate selection such that signal information, from the first two-by-two pixel structure and the second two-by-two pixel structure, corresponding to a same color plane are transferred to a same signal chain.