A print production system that comprises: a source of a sheet of packaging material including a packaging material requirement specification and packaging material vendor; a printer having a printer plate that is configured to transfer images to the sheet of packaging material to yield a printed sheet with a predetermined box print layout arrangement that minimizes packaging material wastage by nesting multiple customer orders into a single production run, wherein the predetermined box print layout arrangement contains an arrangement of a plurality of box patterns that minimize areas of un-utilized regions of the printer plate; a cutting system that converts the printed sheet into individual pieces of packaging material; a packaging system that assembles the individual pieces of packaging material into boxes such that each box exhibits a grain direction that is parallel to a width axis; and a processor that is configured to: print the sheet, cut the printed sheet, and package pieces of packaging material based on aggregated customer orders subject to constraints of order delivery timing and packaging material properties requirements; and optimize the predetermined box print layout arrangement based on printer and supplier prospective input parameters; wherein the predetermined box print layout arrangement is optimized by sequential optimization based on the design or type of boxes produced, and wherein the boxes are sequentially allocated in the predetermined box print layout arrangement as per the following sequence: (a) up and down setting, (b) normal setting, and (c) square setting. a source of a sheet of packaging material including a packaging material requirement specification and packaging material vendor; a printer having a printer plate that is configured to transfer images to the sheet of packaging material to yield a printed sheet with a predetermined box print layout arrangement that minimizes packaging material wastage by nesting multiple customer orders into a single production run, wherein the predetermined box print layout arrangement contains an arrangement of a plurality of box patterns that minimize areas of un-utilized regions of the printer plate; a cutting system that converts the printed sheet into individual pieces of packaging material; a packaging system that assembles the individual pieces of packaging material into boxes such that each box exhibits a grain direction that is parallel to a width axis; and a processor that is configured to: print the sheet, cut the printed sheet, and package pieces of packaging material based on aggregated customer orders subject to constraints of order delivery timing and packaging material properties requirements; and optimize the predetermined box print layout arrangement based on printer and supplier prospective input parameters; print the sheet, cut the printed sheet, and package pieces of packaging material based on aggregated customer orders subject to constraints of order delivery timing and packaging material properties requirements; and optimize the predetermined box print layout arrangement based on printer and supplier prospective input parameters; wherein the predetermined box print layout arrangement is optimized by sequential optimization based on the design or type of boxes produced, and wherein the boxes are sequentially allocated in the predetermined box print layout arrangement as per the following sequence: (a) up and down setting, (b) normal setting, and (c) square setting.