A locking assembly (240, 440, 540) for fluid ends, comprising: a first actuator (241, 464, 541), the first actuator comprising one or more coupling surfaces (284, 466); a second actuator (242, 441, 542) disposed at least partially below the first actuator, the second actuator comprising: a body (280, 442, 581), the body comprising one or more tapered interfacing surfaces (261, 444, 561); one or more coupling surfaces (285, 452) disposed in coupling engagement with the one or more coupling surfaces (284, 466) of the first actuator; and a center axis (286, 447) extending in a longitudinal direction through the body (280, 442, 581), wherein the one or more tapered interfacing surfaces (261, 444, 561) taper inward at an angle relative to the center axis; a plurality of wedges (243, 448, 543) disposed about the second actuator (242, 441, 542) and movable between an unlocked position and a locked position, each wedge of the plurality of wedges comprising: a set of one or more external locking surfaces (2002, 4002, 5002); a set of one or more tapered interfacing surfaces (262, 449, 562), wherein the one or more tapered interfacing surfaces of each wedge is configured to engage with one of the one or more tapered interfacing surfaces (261, 444, 561) of the second actuator; and a lock ring (247, 475, 547) disposed about the plurality of wedges (243, 448, 543), the lock ring comprising a set of one or more internal locking surfaces (2001, 4001, 5001) configured to engage with the external locking surfaces (2002, 4002, 5002) of each wedge of the plurality of wedges; and wherein the body (280, 442, 581) of the second actuator (242, 441, 542) comprises a plurality of guide blocks (244, 453, 544); and each wedge of the plurality of wedges (243, 448, 543) comprises a guide slot (251, 456, 457, 551) formed in a respective tapered interfacing surface of the set of one or more tapered interfacing surfaces of the respective wedge, and each guide slot includes a guide block of the plurality of guide blocks disposed at least partially in the respective guide slot. a first actuator (241, 464, 541), the first actuator comprising one or more coupling surfaces (284, 466); a second actuator (242, 441, 542) disposed at least partially below the first actuator, the second actuator comprising: a body (280, 442, 581), the body comprising one or more tapered interfacing surfaces (261, 444, 561); one or more coupling surfaces (285, 452) disposed in coupling engagement with the one or more coupling surfaces (284, 466) of the first actuator; and a center axis (286, 447) extending in a longitudinal direction through the body (280, 442, 581), wherein the one or more tapered interfacing surfaces (261, 444, 561) taper inward at an angle relative to the center axis; a body (280, 442, 581), the body comprising one or more tapered interfacing surfaces (261, 444, 561); one or more coupling surfaces (285, 452) disposed in coupling engagement with the one or more coupling surfaces (284, 466) of the first actuator; and a center axis (286, 447) extending in a longitudinal direction through the body (280, 442, 581), wherein the one or more tapered interfacing surfaces (261, 444, 561) taper inward at an angle relative to the center axis; a plurality of wedges (243, 448, 543) disposed about the second actuator (242, 441, 542) and movable between an unlocked position and a locked position, each wedge of the plurality of wedges comprising: a set of one or more external locking surfaces (2002, 4002, 5002); a set of one or more tapered interfacing surfaces (262, 449, 562), wherein the one or more tapered interfacing surfaces of each wedge is configured to engage with one of the one or more tapered interfacing surfaces (261, 444, 561) of the second actuator; and a set of one or more external locking surfaces (2002, 4002, 5002); a set of one or more tapered interfacing surfaces (262, 449, 562), wherein the one or more tapered interfacing surfaces of each wedge is configured to engage with one of the one or more tapered interfacing surfaces (261, 444, 561) of the second actuator; and a lock ring (247, 475, 547) disposed about the plurality of wedges (243, 448, 543), the lock ring comprising a set of one or more internal locking surfaces (2001, 4001, 5001) configured to engage with the external locking surfaces (2002, 4002, 5002) of each wedge of the plurality of wedges; and wherein the body (280, 442, 581) of the second actuator (242, 441, 542) comprises a plurality of guide blocks (244, 453, 544); and each wedge of the plurality of wedges (243, 448, 543) comprises a guide slot (251, 456, 457, 551) formed in a respective tapered interfacing surface of the set of one or more tapered interfacing surfaces of the respective wedge, and each guide slot includes a guide block of the plurality of guide blocks disposed at least partially in the respective guide slot.