An apparatus for delivery of an ultrasound-guided drug-loaded microbubble, comprising: a delivery module, configured to emit a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region; an imaging module, configured to emit a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image; an identification module, configured to identify a contour of a blood vessel of the breaking region based on the ultrasound image; a first parameter adjustment module, configured to update a characteristic parameter of the breaking region based on the contour of the blood vessel; a second parameter adjustment module, configured to adjust locations and shapes of a plurality of regions of interest of the breaking region based on the contour of the blood vessel; an evaluation module, configured to obtain evaluation data of concentrations of drug-loaded microbubbles in the plurality of regions of interest based on the locations and shapes of the plurality of regions of interest; and a voltage adjustment module, configured to adjust, based on the evaluation data of the concentrations of drug-loaded microbubbles, an ultrasonic voltage used when the array transducer emits the first ultrasonic signal; characterized in that, the plurality of regions of interest comprise an upstream region of interest and a downstream region of interest, and the second parameter adjustment module is further configured to divide the contour of the blood vessel of the breaking region into the upstream region of interest and the downstream region of interest by taking a center line of the breaking region as a dividing line, to learn locations and shapes of the upstream region of interest and the downstream region of interest. a delivery module, configured to emit a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region; an imaging module, configured to emit a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image; an identification module, configured to identify a contour of a blood vessel of the breaking region based on the ultrasound image; a first parameter adjustment module, configured to update a characteristic parameter of the breaking region based on the contour of the blood vessel; a second parameter adjustment module, configured to adjust locations and shapes of a plurality of regions of interest of the breaking region based on the contour of the blood vessel; an evaluation module, configured to obtain evaluation data of concentrations of drug-loaded microbubbles in the plurality of regions of interest based on the locations and shapes of the plurality of regions of interest; and a voltage adjustment module, configured to adjust, based on the evaluation data of the concentrations of drug-loaded microbubbles, an ultrasonic voltage used when the array transducer emits the first ultrasonic signal; characterized in that, the plurality of regions of interest comprise an upstream region of interest and a downstream region of interest, and the second parameter adjustment module is further configured to divide the contour of the blood vessel of the breaking region into the upstream region of interest and the downstream region of interest by taking a center line of the breaking region as a dividing line, to learn locations and shapes of the upstream region of interest and the downstream region of interest.