A tissue-removing catheter comprising: an elongate catheter body configured for insertion into a body lumen of a subject, the catheter body having opposite distal and proximal ends,and a longitudinal axis (LA 1) extending between the distal and proximal ends; a rotatable cutter located generally at the distal end of the catheter body, the cutter having a proximal end, a distal end, and a longitudinal axis (LA 3) extending between the proximal and distal ends, the cutter includeing a central hub extending generally along the longitudinal axis (LA 3) of the cutter and having a circumference, the central hub having a central hub surface at a distal end of the central hub, a plurality of flutes spaced apart from one another around the circumference of the central hub and extending through the distal end of the cutter and generally longitudinally along the cutter, a plurality of arcuate cutting members at the distal end of the cutter, each cutting member having a leading end, a trailing end, and an arc length extending between the leading and trailing ends (226a, 226b) and partially surrounding the circumference of the hub, whereby each arcuate cutting member is spaced apart from an adjacent one of the arcuate cutting members by one of the flutes, each cutting member including an arcuate cutting edge extending along the arc length of the cutting member for cutting tissue as the cutter is rotated, wherein the tissue-removing catheter is characterised in that each cutting member includes a raised element located adjacent the leading end of the cutting member and extending distally outward relative to the central hub surface, the raised element having a leading cutting edge at the leading end of the cutting member for cutting tissue as the cutter is rotated, and a clearance portion that is recessed, relative to the longitudinal axis (LA 3) of the cutter, from the raised element and extends from the raised element to the trailing end of the cutting member to provide clearance for the leading cutting edge of an adjacent and opposing cutting member. an elongate catheter body configured for insertion into a body lumen of a subject, the catheter body having opposite distal and proximal ends,and a longitudinal axis (LA 1) extending between the distal and proximal ends; a rotatable cutter located generally at the distal end of the catheter body, the cutter having a proximal end, a distal end, and a longitudinal axis (LA 3) extending between the proximal and distal ends, a central hub extending generally along the longitudinal axis (LA 3) of the cutter and having a circumference, the central hub having a central hub surface at a distal end of the central hub, a plurality of flutes spaced apart from one another around the circumference of the central hub and extending through the distal end of the cutter and generally longitudinally along the cutter, a plurality of arcuate cutting members at the distal end of the cutter, each cutting member having a leading end, a trailing end, and an arc length extending between the leading and trailing ends (226a, 226b) and partially surrounding the circumference of the hub, whereby each arcuate cutting member is spaced apart from an adjacent one of the arcuate cutting members by one of the flutes, each cutting member including an arcuate cutting edge extending along the arc length of the cutting member for cutting tissue as the cutter is rotated, wherein the tissue-removing catheter is characterised in that each cutting member includes a raised element located adjacent the leading end of the cutting member and extending distally outward relative to the central hub surface, the raised element having a leading cutting edge at the leading end of the cutting member for cutting tissue as the cutter is rotated, and a clearance portion that is recessed, relative to the longitudinal axis (LA 3) of the cutter, from the raised element and extends from the raised element to the trailing end of the cutting member to provide clearance for the leading cutting edge of an adjacent and opposing cutting member. an arcuate cutting edge extending along the arc length of the cutting member for cutting tissue as the cutter is rotated, wherein the tissue-removing catheter is characterised in that each cutting member includes a raised element located adjacent the leading end of the cutting member and extending distally outward relative to the central hub surface, the raised element having a leading cutting edge at the leading end of the cutting member for cutting tissue as the cutter is rotated, and a clearance portion that is recessed, relative to the longitudinal axis (LA 3) of the cutter, from the raised element and extends from the raised element to the trailing end of the cutting member to provide clearance for the leading cutting edge of an adjacent and opposing cutting member.