mhurhangee/ep-ind-claims huggingface dataset:
A method of making an antibody that recognizes the same antigen as a non-human reference antibody, the method comprising: (a) joining a heavy chain CDR3-FR4 that comprises a CDR3 D segment from the reference antibody linked to a FR4, to a human V H V-segment repertoire thereby creating a library of V H regions; (b) joining a light chain CDR3-FR4 that comprises a CDR3 binding specificity determinant from the reference antibody linked to a FR4, to a human V L V-segment repertoire thereby creating a library of V L regions; (c) combining the libraries of steps (a) and (b) to create an antibody library comprising members where a member has one V H comprising a CDR3-FR4 linked to a V-segment from the V H V-segment repertoire and one V L comprising a CDR3-FR4 linked to a V-segment from the V L V-segment repertoire; and (d) isolating a member of the library of step (c) that binds the same antigen as the reference antibody. (a) joining a heavy chain CDR3-FR4 that comprises a CDR3 D segment from the reference antibody linked to a FR4, to a human V H V-segment repertoire thereby creating a library of V H regions; (b) joining a light chain CDR3-FR4 that comprises a CDR3 binding specificity determinant from the reference antibody linked to a FR4, to a human V L V-segment repertoire thereby creating a library of V L regions; (c) combining the libraries of steps (a) and (b) to create an antibody library comprising members where a member has one V H comprising a CDR3-FR4 linked to a V-segment from the V H V-segment repertoire and one V L comprising a CDR3-FR4 linked to a V-segment from the V L V-segment repertoire; and (d) isolating a member of the library of step (c) that binds the same antigen as the reference antibody.
A sitting position adjustment system for adjusting a sitting position of a user of a seat, said sitting position adjustment system comprising - a pressure distribution determination system for determining a pressure distribution of said user in said seat, characterized in that said sitting position adjustment system further comprises - a micro-adjustment system for making micro-adjustments of a sitting surface of said seat based on said determined pressure distribution, said micro-adjustment system being adapted to operate in the millimetre range and/or the submillimetre range. - a pressure distribution determination system for determining a pressure distribution of said user in said seat, characterized in that said sitting position adjustment system further comprises - a micro-adjustment system for making micro-adjustments of a sitting surface of said seat based on said determined pressure distribution, said micro-adjustment system being adapted to operate in the millimetre range and/or the submillimetre range.
Actinomycete Streptomyces beta-vulgaris strain having a sequence of rDNA 16S SEQ No. 1, said strain being deposited at the CNCM under number I-3639 or obtained by selective mutation from the strain deposited at the CNCM under number I-3639, said strain being efficient for: - stimulating the growth of plants, and/or - struggling against the phytopathogenic agents, and/or - stimulating the natural defenses of plants, and/or - improving the assimilation of nutrients by the plants. - stimulating the growth of plants, and/or - struggling against the phytopathogenic agents, and/or - stimulating the natural defenses of plants, and/or - improving the assimilation of nutrients by the plants.
A method for amplifying bisulfite-treated DNA derived from an archived sample by polymerase chain reaction, comprising amplifying bisulfite-treated DNA in a DNA amplification step comprising use of a polymerase concentration in the range of 0.05 to 0.3 U/μl and a concentration of each nucleotide in the range of 350 to 650 μmol/l.
Silica for use in the treatment of skin conditions selected from the group consisting of skin damage due to cortico steroids, skin atrophy, structural weakness of the connective tissue, wound healing, atophic dermatitis, eczema, psoriasis, rosacea.
A process for simultaneously amplifying at least a first and a second target nucleic acid that may be present in a fluid sample, said process comprising the automated steps of: d. contacting nucleic acids from said sample with one or more amplification reagents comprising a polymerase with reverse transcriptase activity in at least two reaction vessels for amplification of the at least first and second target nucleic acids in the at least two reaction vessels; e. incubating in said reaction vessels said nucleic acids with said one or more amplification reagents for a period of time and under conditions suitable for transcription of RNA by said polymerase with reverse transcriptase activity to occur, wherein the incubation of the polymerase with reverse transcriptase activity is carried out at 55°C, 60°C, and 65°C; f. incubating in said reaction vessels said nucleic acids with said one or more amplification reagents for a period of time and under conditions sufficient for an amplification reaction indicative of the presence or absence of said first and second target nucleic acid to occur while amplifying the first, but not the second target nucleic acid in the first reaction vessel and the second, but not the first target nucleic acid in the second reaction vessel, using probes to detect the amplificates of the target nucleic acids, wherein the conditions for transcription and amplification in steps d. to f. are identical for the at least first and second target nucleic acids, and wherein the at least two target nucleic acids comprise RNA and DNA. d. contacting nucleic acids from said sample with one or more amplification reagents comprising a polymerase with reverse transcriptase activity in at least two reaction vessels for amplification of the at least first and second target nucleic acids in the at least two reaction vessels; e. incubating in said reaction vessels said nucleic acids with said one or more amplification reagents for a period of time and under conditions suitable for transcription of RNA by said polymerase with reverse transcriptase activity to occur, wherein the incubation of the polymerase with reverse transcriptase activity is carried out at 55°C, 60°C, and 65°C; f. incubating in said reaction vessels said nucleic acids with said one or more amplification reagents for a period of time and under conditions sufficient for an amplification reaction indicative of the presence or absence of said first and second target nucleic acid to occur while amplifying the first, but not the second target nucleic acid in the first reaction vessel and the second, but not the first target nucleic acid in the second reaction vessel, using probes to detect the amplificates of the target nucleic acids,
A control device for controlling the valve of an internal-combustion engine; the control device comprising: - a rocker arm, which is mounted so as to be rotatable about a first axis and can be coupled to a shaped shaft, in particular a camshaft; - a driving foot configured to act on the valve; - an actuation device (22, 23, 18, 16) housed within the rocker arm for selectively transmitting a movement between the shaped shaft and the valve; - a driving duct in communication with the actuation device (22, 23, 18, 16); the driving duct being configured to hydraulically enable or disable the actuation device (22, 23, 18, 16); preferably the valve is an exhaust or intake valve; the control device being characterized in that: the rocker arm comprises a driving piston and a first chamber, preferably a compensation chamber, that houses part of the driving piston, which in turn defines the position of the driving foot; a driving valve; and a second chamber, preferably the second chamber is housed in the driving valve; the driving duct is in connection with the first chamber via the driving valve; the driving valve is arranged between the first chamber and the driving duct; wherein the driving valve comprises a third chamber in communication with the second chamber via a protection element interposed between the second and the third chambers (23, 42). - a rocker arm, which is mounted so as to be rotatable about a first axis and can be coupled to a shaped shaft, in particular a camshaft; - a driving foot configured to act on the valve; - an actuation device (22, 23, 18, 16) housed within the rocker arm for selectively transmitting a movement between the shaped shaft and the valve; - a driving duct in communication with the actuation device (22, 23, 18, 16); the driving duct being configured to hydraulically enable or disable the actuation device (22, 23, 18, 16); preferably the valve is an exhaust or intake valve; the rocker arm comprises a driving piston and a first chamber, preferably a compensation chamber, that houses part of the driving piston, which in turn defines the position of the driving foot; a driving valve; and a second chamber, preferably the second chamber is housed in the driving valve; the driving duct is in connection with the first chamber via the driving valve; the driving valve is arranged between the first chamber and the driving duct; wherein the driving valve comprises a third chamber in communication with the second chamber via a protection element interposed between the second and the third chambers (23, 42).
A polycarbosilazane comprising a repeating unit represented by the following formula and a repeating unit represented by the following formula: wherein, R 1, R 2, and R 3 are each independently a single bond, hydrogen or C 1-4 alkyl; R 4, R 5, and R 6 are each independently a single bond or hydrogen; provided that when R 1, R 2, R 4, and R 5 are single bonds, R 1, R 2, R 4, and R 5 are bonded to N contained in other repeating units, and when R 3 and R 6 are single bonds, R 3 and R 6 are bonded to N contained in other repeating units; and n and m are each independently 1 to 3. R 1, R 2, and R 3 are each independently a single bond, hydrogen or C 1-4 alkyl; R 4, R 5, and R 6 are each independently a single bond or hydrogen; provided that when R 1, R 2, R 4, and R 5 are single bonds, R 1, R 2, R 4, and R 5 are bonded to N contained in other repeating units, and when R 3 and R 6 are single bonds, R 3 and R 6 are bonded to N contained in other repeating units; and n and m are each independently 1 to 3.
A solenoid valve device, comprising: a solenoid valve that includes a solenoid that is supplied with driving current to generate magnetic flux, and a valve element that is moved by the magnetic flux generated from the solenoid; and a control device that controls the solenoid valve, characterized in that the control device includes an alternating current component in the driving current and supplies the driving current including the alternating current component to the solenoid, and detects an impedance of the solenoid. a solenoid valve that includes a solenoid that is supplied with driving current to generate magnetic flux, and a valve element that is moved by the magnetic flux generated from the solenoid; and a control device that controls the solenoid valve, characterized in that the control device includes an alternating current component in the driving current and supplies the driving current including the alternating current component to the solenoid, and detects an impedance of the solenoid.
A refrigerant vapor compression system comprising: a compressor for compressing a refrigerant, the compressor having a suction port and a discharge port; a refrigerant heat rejection heat exchanger operatively coupled downstream to the discharge port of the compressor; a refrigerant heat absorption heat exchanger operatively coupled downstream to the refrigerant heat rejection heat exchanger; a compressor suction inlet line connecting the refrigerant heat absorption heat exchanger to the suction port of the compressor; an adiabatic expansion device operatively coupled to the suction inlet line; a sensor (78,84) operatively coupled to the suction inlet line for measuring a superheat value of the refrigerant; and a controller in communication with the sensor, characterised in that: the controller is configured to operate the refrigerant vapor compression system in a first mode when a pressure of the refrigerant downstream of the adiabatic expansion device is greater than a threshold value, and operate the refrigerant vapor compression system in a second mode when the pressure of the refrigerant downstream of the adiabatic expansion device is less than the threshold value, the threshold value being indicative of a pressure at which expansion across the adiabatic expansion device would result in formation of solid-phase refrigerant; and a bypass line connecting the discharge port of the compressor to the suction port of the compressor, the bypass line having an unload valve to regulate the refrigerant flow therethrough, the second mode of operation including opening the unload valve to.admit higher-temperature refrigerant to the suction port of the compressor; wherein the adiabatic expansion device is positioned upstream with respect to refrigerant flow of a point where the bypass line connects to the suction inlet line; and wherein the compressor continues to operate in both modes. a compressor for compressing a refrigerant, the compressor having a suction port and a discharge port; a refrigerant heat rejection heat exchanger operatively coupled downstream to the discharge port of the compressor; a refrigerant heat absorption heat exchanger operatively coupled downstream to the refrigerant heat rejection heat exchanger; a compressor suction inlet line connecting the refrigerant heat absorption heat exchanger to the suction port of the compressor; an adiabatic expansion device operatively coupled to the suction inlet line; a sensor (78,84) operatively coupled to the suction inlet line for measuring a superheat value of the refrigerant; and a controller in communication with the sensor,
A wireless communication unit comprising a transmitter having a power amplifier biased by a bias circuit and a controller operably coupled to the bias circuit for setting one or more bias levels applied to the power amplifier, wherein the bias circuit is a single bias circuit configured to provide either a current mode bias control of the power amplifier or a voltage mode bias control of the power amplifier in response to a control signal from the controller wherein the bias circuit comprises a current source operably coupled to an input port of the power amplifier via a first switch that is configured by the controller to be in a closed position when biasing the power amplifier in a current mode and in an open position when biasing the power amplifier in a voltage mode, and wherein the bias circuit comprises a current-to-voltage converter circuit that is activated when biasing the power amplifier in a voltage mode, and wherein the current-to-voltage converter circuit is located between the current source and the input port of the power amplifier wherein the current-to-voltage converter circuit comprises a reference transistor, a second switch located between the current source and the reference transistor and a third switch located between a base port of the reference transistor and the input port of the power amplifier wherein the second switch and third switch are configured by the controller to be: in a closed position when biasing the power amplifier in a voltage mode, and in an open position when biasing the power amplifier in a current mode. in a closed position when biasing the power amplifier in a voltage mode, and in an open position when biasing the power amplifier in a current mode.
An air conditioner comprising: an air intake port; a heat exchanger configured for exchanging heat with the introduced air; an air discharge unit configured for discharging the heat exchanged air; and a blowing unit configured for introducing air through the air intake port and via the heat exchanger and transmitting the heat exchanged air toward the air discharge unit, wherein the air discharge unit has a space through which the heat exchanged air is discharged and a ring-shaped air discharge port formed along the periphery of the space to allow the heat exchanged air to be discharged to the space, characterized in that the space is open in the front-rear direction through the air discharge unit, wherein the air discharge unit includes: a front inner body having the space formed therein; a rear inner body having a front end thereof inserted in the space so as to form the ring-shaped air discharge port together with the front inner body; and an outer case forming an air passage together with the rear inner body, through which the air introduced into the outer case can be discharged, wherein the rear inner body has a rear space formed inside thereof such that the rear space communicates with the space in the front-rear direction, and wherein the front inner body has a front extending portion formed ahead of the ring-shaped air discharge port, an inner diameter of the front extending portion being larger than a diameter of the front end of the rear inner body. an air intake port; a heat exchanger configured for exchanging heat with the introduced air; an air discharge unit configured for discharging the heat exchanged air; and a blowing unit configured for introducing air through the air intake port and via the heat exchanger and transmitting the heat exchanged air toward the air discharge unit, wherein the air discharge unit has a space through which the heat exchanged air is discharged and a ring-shaped air discharge port formed along the periphery of the space to allow the heat exchanged air to be discharged to the space, characterized in that the space is open in the front-rear direction through the air discharge unit, wherein the air discharge unit includes: a front inner body having the space formed therein; a rear inner body having a front end thereof inserted in the space so as to form the ring-shaped air discharge port together with the front inner body; and an outer case forming an air passage together with the rear inner body, through which the air introduced into the outer case can be discharged, wherein the rear inner body has a rear space formed inside thereof such that the rear space communicates with the space in the front-rear direction, and wherein the front inner body has a front extending portion formed ahead of the ring-shaped air discharge port, an inner diameter of the front extending portion being larger than a diameter of the front end of the rear inner body.
A compound for use in a method of treating lung adenocarcinoma in a patient, wherein the compound is the malate salt of Compound 1: and wherein the lung adenocarcinoma is KIF5B-RET fusion-positive non-small cell lung cancer.
A green ball grinding method comprising the steps of: supplying a green ball between a first surface of a first member having a first plane and a second surface of a second member having a second plane facing the first plane constituting a grinding apparatus, and grinding said green ball between said first plane of said first surface and said second plane of said second surface while said green ball rotates around its own axis and in orbital motion, in said step of grinding said green ball, the step of causing said green ball grinding to proceed while applying load between said green ball and each of said first surface and said second surface, characterized in that, the green ball grinding method is further comprising the step of modifying a rotation axis of said green ball by reducing said load lower than in the step of causing said green ball grinding to proceed, wherein the step of causing said green ball grinding to proceed and the step of modifying a rotation axis are executed alternately, and wherein in the step of modifying a rotation axis of said green ball is controlled so that the load applied to said green ball is zero. supplying a green ball between a first surface of a first member having a first plane and a second surface of a second member having a second plane facing the first plane constituting a grinding apparatus, and grinding said green ball between said first plane of said first surface and said second plane of said second surface while said green ball rotates around its own axis and in orbital motion, in said step of grinding said green ball, the step of causing said green ball grinding to proceed while applying load between said green ball and each of said first surface and said second surface, characterized in that, the green ball grinding method is further comprising the step of modifying a rotation axis of said green ball by reducing said load lower than in the step of causing said green ball grinding to proceed, wherein the step of causing said green ball grinding to proceed and the step of modifying a rotation axis are executed alternately, and wherein in the step of modifying a rotation axis of said green ball is controlled so that the load applied to said green ball is zero.
A monitoring system for a working machine, comprising: a first communicator device to communicate wirelessly, the first communicator device being provided on the working machine including a working device and a traveling device; a second communicator device to communicate with the first communicator device wirelessly, the second communicator device being provided on a monitoring device installed in an agricultural field; a monitor to monitor the agricultural field, the monitor being provided on the monitoring device; a judgment analyzer to judge whether the working machine is in a monitoring area of the monitor based on intensities of signals of the first communicator device and the second communicator device, the judgment analyzer being provided on the monitoring device; and an instruction controller to instruct the monitor to start monitoring when the judgment analyzer determines that the working machine is in the monitoring area, the instruction controller being provided on the working machine, wherein the monitoring device is a field server to collect information about the agricultural field and crops to be grown in the agricultural field. a first communicator device to communicate wirelessly, the first communicator device being provided on the working machine including a working device and a traveling device; a second communicator device to communicate with the first communicator device wirelessly, the second communicator device being provided on a monitoring device installed in an agricultural field; a monitor to monitor the agricultural field, the monitor being provided on the monitoring device; a judgment analyzer to judge whether the working machine is in a monitoring area of the monitor based on intensities of signals of the first communicator device and the second communicator device, the judgment analyzer being provided on the monitoring device; and an instruction controller to instruct the monitor to start monitoring when the judgment analyzer determines that the working machine is in the monitoring area, the instruction controller being provided on the working machine, wherein the monitoring device is a field server to collect information about the agricultural field and crops to be grown in the agricultural field.