mhurhangee/ep-ind-claims huggingface dataset:
A recombinant fusion protein, comprising i) an extracellular Ig-like domain of a signal-regulatory protein (SIRP), and ii) an Ig-like anti-HER2 antibody, wherein the extracellular Ig-like domain of the signal-regulatory protein is linked via a linker to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a light chain constituting the paratope, wherein the signal-regulatory protein is SIRPα, wherein the extracellular Ig-like domain of the signal-regulatory protein is first extracellular Ig-like domain of signal-regulatory protein (SIRPαD1), wherein SIRPαD1 comprises the amino acid of SEQ ID NO: 2, wherein the Ig-like anti-HER2 antibody comprises two heavy chains each having an amino acid sequence of SEQ ID NO: 6, and two light chains each having an amino acid sequence of SEQ ID NO: 8, and wherein the recombinant fusion protein is capable of blocking binding of CD47s on cancer cells to SIRPs on surfaces of macrophages, binding to HER2s on cancer cells to inhibit uncontrolled cancer cell growth, and binding to FcRs on NK cells or macrophages. i) an extracellular Ig-like domain of a signal-regulatory protein (SIRP), and ii) an Ig-like anti-HER2 antibody, wherein the extracellular Ig-like domain of the signal-regulatory protein is linked via a linker to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a light chain constituting the paratope, wherein the signal-regulatory protein is SIRPα, wherein the extracellular Ig-like domain of the signal-regulatory protein is first extracellular Ig-like domain of signal-regulatory protein (SIRPαD1), wherein SIRPαD1 comprises the amino acid of SEQ ID NO: 2, wherein the Ig-like anti-HER2 antibody comprises two heavy chains each having an amino acid sequence of SEQ ID NO: 6, and two light chains each having an amino acid sequence of SEQ ID NO: 8, and wherein the recombinant fusion protein is capable of blocking binding of CD47s on cancer cells to SIRPs on surfaces of macrophages, binding to HER2s on cancer cells to inhibit uncontrolled cancer cell growth, and binding to FcRs on NK cells or macrophages.
Smoke grenade having an active smoke compound for production of a concealment smoke and having a break-up charge for breaking up and firing the active smoke compound, wherein a delay charge is provided, which results in the break-up charge becoming effective with a delay, wherein the break-up charge comprises a charge based on explosive, characterized in that the active smoke compound comprises a charge with a detonation effect.
Closing device for closing a functionally essential component of a vehicle, in particular a radiator of the vehicle, with at least one closing element for regulating an air inlet to the functionally essential component, and a support element for receiving the at least one closing element, wherein the closing device comprises at least one deformation element for the absorption of impact energy at the vehicle, characterized in that the deformation element serves to fasten the closing device to a mounting support, wherein the mounting support is configured to fasten a plurality of functional components and/or functionally essential components of the vehicle, wherein the deformation element serves as an energy absorber for pedestrian protection during an impact of the vehicle, and comprises at least one hollow chamber.
A gas sensor comprising: a conductive material comprising a carbon-carbon multiple bond moiety, the conductive material being in electrical communication with at least two electrodes, wherein the conductive material includes a plurality of single-walled carbon nanotubes; and a transition metal complex coordinately or covalently bound to the carbon-carbon multiple bond moiety in the nanotube framework of the conductive material, and wherein the transition metal complex is capable of forming a stable complex with ethylene, wherein the gas sensor is an ethylene sensor. a conductive material comprising a carbon-carbon multiple bond moiety, the conductive material being in electrical communication with at least two electrodes, wherein the conductive material includes a plurality of single-walled carbon nanotubes; and a transition metal complex coordinately or covalently bound to the carbon-carbon multiple bond moiety in the nanotube framework of the conductive material, and wherein the transition metal complex is capable of forming a stable complex with ethylene, wherein the gas sensor is an ethylene sensor.
A gas turbine engine defining a radial direction R, the gas turbine engine comprising: a core engine including an outer casing; an engine air flowpath extending through the core engine; a cooling air flowpath extending outwardly generally along the radial direction R between an inlet in flow communication with the engine air flowpath and an outlet defined by an opening in the outer casing of the core engine; and a heat exchanger positioned at least partially within the outer casing of the core engine, the cooling air flowpath extending over or through the heat exchanger; wherein the core engine defines a plurality of bleed air flowpaths extending outwardly generally along the radial direction R from the engine air flowpath through the outer casing, wherein the gas turbine engine further defines a circumferential direction C, and wherein the bleed air flowpaths and the cooling air flowpath are spaced along the circumferential direction C; and wherein the core engine includes an inner liner and an outer liner spaced from one another along the radial direction R and at least partially defining the engine air flowpath, wherein the core engine also includes a pair of sidewalls extending outwardly along the radial direction R from the outer liner at least partially defining the cooling air flowpath, wherein each of the sidewalls defines an opening allowing for air to flow between the cooling air flowpath and one or more of the bleed air flowpaths. a core engine including an outer casing; an engine air flowpath extending through the core engine; a cooling air flowpath extending outwardly generally along the radial direction R between an inlet in flow communication with the engine air flowpath and an outlet defined by an opening in the outer casing of the core engine; and a heat exchanger positioned at least partially within the outer casing of the core engine, the cooling air flowpath extending over or through the heat exchanger; wherein the core engine defines a plurality of bleed air flowpaths extending outwardly generally along the radial direction R from the engine air flowpath through the outer casing, wherein the gas turbine engine further defines a circumferential direction C, and wherein the bleed air flowpaths and the cooling air flowpath are spaced along the circumferential direction C; and wherein the core engine includes an inner liner and an outer liner spaced from one another along the radial direction R and at least partially defining the engine air flowpath, wherein the core engine also includes a pair of sidewalls extending outwardly along the radial direction R from the outer liner at least partially defining the cooling air flowpath, wherein each of the sidewalls defines an opening allowing for air to flow between the cooling air flowpath and one or more of the bleed air flowpaths.
A turbine blade rotor assembly for a gas turbine engine comprising: a rotor; nickel alloy turbine blades each having a root and an airfoil, the roots supported by the rotor; and a ceramic platform supported between each pair of the turbine blades adjacent to the airfoils, wherein the turbine blades include leading and trailing edges (26, 28) opposite one another; and characterised by further comprising leading and trailing flow guides supported by the rotor and arranged axially from the leading and trailing edges (26, 28) respectively, the flow guides being discrete from the platforms. a rotor; nickel alloy turbine blades each having a root and an airfoil, the roots supported by the rotor; and a ceramic platform supported between each pair of the turbine blades adjacent to the airfoils, wherein the turbine blades include leading and trailing edges (26, 28) opposite one another; and characterised by further comprising leading and trailing flow guides supported by the rotor and arranged axially from the leading and trailing edges (26, 28) respectively, the flow guides being discrete from the platforms.
Multilayer film comprising at least one first and one second layer of plasticized polyvinyl acetal characterised in that the first layer comprises a first plasticizer and a first polyvinyl acetal with a degree of acetalization of 75.1- 84.0 mol % and a molar ratio of the amount of continuous sequences of vinyl alcohol groups with 5 members with a stereochemical sequence of rrrr of more than 0,23 based on the total amount of continuous syndiotactic sequences of vinyl alcohol groups with 3 members in the polyvinyl acetal and the second layer comprises a second plasticizer and a second polyvinyl acetal with a degree of acetalization of 60 - 84 mol %.
Cash box, comprising a housing, and comprising a base tray arranged within the housing, wherein the base tray at least partly delimits a receiving region for receiving a stack of notes of value, and wherein the notes of value of the stack of notes of value that is received stand with their edges on a bottom element of the base tray, wherein the base tray is movable relative to the housing between a removal position and a retracted position, wherein the cash box comprises a displacement unit for moving the base tray between the retracted position and the removal position, and wherein the cash box has an opening for the mechanical supply and/or removal of notes of value, and wherein a front side of the base tray, facing this opening, has a shorter distance from the opening in the removal position than in the retracted position, and wherein, on its front side facing an opening of the cash box for the mechanical supply and/or removal, the base tray has a front wall, which delimits the receiving region in the direction of the opening, and wherein a slot for notes of value to be fed through is provided between the bottom element and the front wall. comprising a housing, and comprising a base tray arranged within the housing, wherein the base tray at least partly delimits a receiving region for receiving a stack of notes of value, and wherein the notes of value of the stack of notes of value that is received stand with their edges on a bottom element of the base tray, wherein the base tray is movable relative to the housing between a removal position and a retracted position, wherein the cash box comprises a displacement unit for moving the base tray between the retracted position and the removal position, and wherein the cash box has an opening for the mechanical supply and/or removal of notes of value, and wherein a front side of the base tray, facing this opening, has a shorter distance from the opening in the removal position than in the retracted position, and wherein, on its front side facing an opening of the cash box for the mechanical supply and/or removal, the base tray has a front wall, which delimits the receiving region in the direction of the opening, and wherein a slot for notes of value to be fed through is provided between the bottom element and the front wall.
A method for producing a water absorbent comprising a crosslinked naturally derived polymer and a clay mineral, wherein the method comprises the steps of preparing a starting solution in which a naturally derived polymer is dissolved and a clay mineral is dispersed, and crosslinking the naturally derived polymer by adding a crosslinking agent to the starting solution; wherein the water absorbent comprises 100 parts by dry weight of the crosslinked naturally derived polymer and 10 to 100 parts by dry weight of the clay mineral; wherein the naturally derived polymer is poly(glutamic) acid having a condensable functional group being a carboxyl group; wherein the crosslinking agent is a polyamine; wherein the crosslinking agent is added in an amount of 0.5 to 25 parts by weight based on 100 parts by dry weight of the naturally derived polymer; wherein a condensation agent is used together with the crosslinking agent, the condensation agent being a water-soluble carbodiimide; and wherein a condensation aid is used together with the crosslinking agent, the condensation aid being an N-hydroxyimide.
An injection device for the delivery of a medicament from a container through a needle disposed at the distal end of the container, the container having a stopper for containing the medicament within the container, the device comprising: a housing; an advancing mechanism (190, 204, 230) for moving, when activated, the container relative to the housing from a starting position in which the needle is shrouded and an insertion position in which the needle is exposed; and a stopper drive arrangement for moving, when activated, the stopper towards the distal end of the container, wherein the stopper drive arrangement is moveable with the container, and the advancing mechanism (190, 204, 230) comprises an insertion spring for axially moving the container and the stopper drive arrangement in the distal direction relative to the housing, wherein the stopper drive arrangement comprises a drive body, a driveshaft arranged for rotation with respect to the drive body, a plunger arranged for axial movement with respect to the drive body to move the stopper upon rotation of the driveshaft, and a drive spring housed in the drive body and biased for rotating the driveshaft; and wherein the device further comprises a clutch member moveable with respect to the drive body between a locked position in which the clutch member blocks rotation of the driveshaft and an unlocked position in which the driveshaft can rotate, and wherein, at an activation position during said axial movement of the stopper drive arrangement with the container, the clutch member is moved from the locked position to the unlocked position for activating the stopper drive arrangement. a housing; an advancing mechanism (190, 204, 230) for moving, when activated, the container relative to the housing from a starting position in which the needle is shrouded and an insertion position in which the needle is exposed; and a stopper drive arrangement for moving, when activated, the stopper towards the distal end of the container, wherein the stopper drive arrangement is moveable with the container, and the advancing mechanism (190, 204, 230) comprises an insertion spring for axially moving the container and the stopper drive arrangement in the distal direction relative to the housing, wherein the stopper drive arrangement comprises a drive body, a driveshaft arranged for rotation with respect to the drive body, a plunger arranged for axial movement with respect to the drive body to move the stopper upon rotation of the driveshaft, and a drive spring housed in the drive body and biased for rotating the driveshaft; and wherein the device further comprises a clutch member moveable with respect to the drive body between a locked position in which the clutch member blocks rotation of the driveshaft and an unlocked position in which the driveshaft can rotate, and wherein, at an activation position during said axial movement of the stopper drive arrangement with the container, the clutch member is moved from the locked position to the unlocked position for activating the stopper drive arrangement.
System for conveying planar supports with at least one endless belt arranged with a set of through holes, in a machine for printing supports equipped with at least one printing unit, comprising at least one suction box, comprising: suction means, able to generate an air vacuum, and a suction compartment, divided into at least two separate chambers (26, 27, 28), with a first suction chamber having an adjustable volume with variable capacity, in communication with the suction means, for applying through the holes of the belt the air vacuum to the supports conveyed by the belt, and a second chamber at ambient pressure (26, 27), the first and second chambers (28, 26, 27) being oriented longitudinally, and being separated one from the other by a movable partition (31, 33), so as to adjust the suction box to the format of the planar supports conveyed, characterised in that the suction compartment has an open upper face provided with a holding arrangement (14, 43, 44, 46, 47, 48), the belt moving on the holding arrangement (14, 43, 44, 46, 47, 48). suction means, able to generate an air vacuum, and a suction compartment, divided into at least two separate chambers (26, 27, 28), with a first suction chamber having an adjustable volume with variable capacity, in communication with the suction means, for applying through the holes of the belt the air vacuum to the supports conveyed by the belt, and a second chamber at ambient pressure (26, 27), the first and second chambers (28, 26, 27) being oriented longitudinally, and being separated one from the other by a movable partition (31, 33), so as to adjust the suction box to the format of the planar supports conveyed, characterised in that the suction compartment has an open upper face provided with a holding arrangement (14, 43, 44, 46, 47, 48), the belt moving on the holding arrangement (14, 43, 44, 46, 47, 48).
An apparatus (200, 300, 400) for component positioning, comprising a receptacle (212, 412) configured to receive a number of components to be placed on a target substrate (108, 111), agitator (210, 410) configured to exert force impulses, such as abrupt force impulses, on the receptacle so as to cause the components to change their position including turning over inside the receptacle, inspection equipment (216, 316, 416) configured to verify the position of the components inside the receptacle to identify one or more components that fulfil a predefined position criterion, and pick and place equipment (206, 306, 406) configured to pick said identified one or more components from the receptacle that fulfil the predefined position criterion and place the components on the target substrate while leaving the remaining components in the receptacle for further agitation, characterized by weighing equipment for determining the space available in the receptacle.
A synergistic herbicidal mixture consisting of an herbicidally effective amount of (a) fluroxypyr, or an agriculturally acceptable salt or ester, and (b) penoxsulam.
A data transmission method, comprising: receiving first downlink control information, DCI, from a network device in a common detection space, and receiving first downlink data based on the first DCI, wherein the first downlink data is used to indicate a second detection space, and the first downlink data is a paging message, a random access response, RAR, or a message B, MsgB; and receiving second DCI from the network device in the second detection space, and receiving second downlink data based on the second DCI, wherein the second downlink data is data specific to a terminal device, and the terminal device is in a radio resource control, RRC, non-connected mode. receiving first downlink control information, DCI, from a network device in a common detection space, and receiving first downlink data based on the first DCI, wherein the first downlink data is used to indicate a second detection space, and the first downlink data is a paging message, a random access response, RAR, or a message B, MsgB; and receiving second DCI from the network device in the second detection space, and receiving second downlink data based on the second DCI, wherein the second downlink data is data specific to a terminal device, and the terminal device is in a radio resource control, RRC, non-connected mode.
Gripping means intended to be sealed for its subsequent use in a hardenable material forming part of the object to be grasped formed when this foam material is hardened, comprising a handle or spacer linking two vertical lateral walls (3, 3') mounted on a flat or substantially flat support, said flat or substantially flat support having, on its bottom face opposite that receiving said lateral walls (3, 3'), at least one anchoring means protruding from said gripping means into said hardenable material, or the anchoring means being produced in the form of a horizontal plate parallel or substantially parallel to the flat or substantially flat support and linked thereto by at least one vertical spacer.
An apparatus (1, 1') comprising: pipes (2, 3) having internal longitudinal walls dividing the pipes into channels, a first connecting part attached to first ends of the pipes (2, 3) for providing a flow path between the channels of the pipes, a second connecting part attached to second ends of the pipes for providing a flow path between the channels of the pipes, and a first heat transfer element (11, 11') comprising a base plate (7, 7') with a first surface for receiving a heat load from one or more electric components and for transferring the heat load to a fluid, and a second heat transfer element for receiving the fluid from the first heat transfer element (11, 11'), and for transferring the heat load from the fluid, characterized in that the pipes which are at the location of an electric component are at least partly embedded into the base plate (7, 7') via a second surface of the base plate, while the pipes which are not at the location of an electric component are not embedded into the base plate, the channels of the at least partly embedded pipe or pipes which are located in the embedded part of the respective pipe are evaporator channels which receive said heat load from the one or more electric components to the fluid in the evaporator channels and pass the fluid to the second heat transfer element, and the other channels of the pipes (2, 3) are condenser channels. pipes (2, 3) having internal longitudinal walls dividing the pipes into channels, a first connecting part attached to first ends of the pipes (2, 3) for providing a flow path between the channels of the pipes, a second connecting part attached to second ends of the pipes for providing a flow path between the channels of the pipes, and a first heat transfer element (11, 11') comprising a base plate (7, 7') with a first surface for receiving a heat load from one or more electric components and for transferring the heat load to a fluid, and a second heat transfer element for receiving the fluid from the first heat transfer element (11, 11'), and for transferring the heat load from the fluid, characterized in that the pipes which are at the location of an electric component are at least partly embedded into the base plate (7, 7') via a second surface of the base plate, while the pipes which are not at the location of an electric component are not embedded into the base plate, the channels of the at least partly embedded pipe or pipes which are located in the embedded part of the respective pipe are evaporator channels which receive said heat load from the one or more electric components to the fluid in the evaporator channels and pass the fluid to the second heat transfer element, and the other channels of the pipes (2, 3) are condenser channels.