A clamp assembly comprising: a rail extending along a length and configured to receive a first fluidic assembly (104, 204); and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly (108, 208), the carriage including an actuator and a stop mechanism (66, 68, 70, 72, 74), where the stop mechanism (66, 68, 70, 72, 74) is configured to selectively prevent and allow movement of the carriage relative to the rail, wherein the stop mechanism (66, 68, 70, 72, 74) is configured to be independently operable from the actuator, and wherein the actuator is configured: to move a chromatography column (56, 90, 116, 216) received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column (56, 90, 116, 216) and the first fluidic assembly (104, 204), and move the second fluidic assembly (108, 208) relative to the carriage to create a second fluid tight seal between the second fluidic assembly (108, 208) and the chromatography column (56, 90, 116, 216), wherein the rail is a guide rod and wherein the carriage includes a bore through which the guide rod extends, wherein the carriage is configured to be rotated about the guide rod to move the carriage into and out of a plurality of separate locations along the rail. a rail extending along a length and configured to receive a first fluidic assembly (104, 204); and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly (108, 208), the carriage including an actuator and a stop mechanism (66, 68, 70, 72, 74), where the stop mechanism (66, 68, 70, 72, 74) is configured to selectively prevent and allow movement of the carriage relative to the rail, wherein the stop mechanism (66, 68, 70, 72, 74) is configured to be independently operable from the actuator, and wherein the actuator is configured: to move a chromatography column (56, 90, 116, 216) received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column (56, 90, 116, 216) and the first fluidic assembly (104, 204), and move the second fluidic assembly (108, 208) relative to the carriage to create a second fluid tight seal between the second fluidic assembly (108, 208) and the chromatography column (56, 90, 116, 216), wherein the rail is a guide rod and wherein the carriage includes a bore through which the guide rod extends, wherein the carriage is configured to be rotated about the guide rod to move the carriage into and out of a plurality of separate locations along the rail. to move a chromatography column (56, 90, 116, 216) received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column (56, 90, 116, 216) and the first fluidic assembly (104, 204), and move the second fluidic assembly (108, 208) relative to the carriage to create a second fluid tight seal between the second fluidic assembly (108, 208) and the chromatography column (56, 90, 116, 216), wherein the rail is a guide rod and wherein the carriage includes a bore through which the guide rod extends, wherein the carriage is configured to be rotated about the guide rod to move the carriage into and out of a plurality of separate locations along the rail.