Micro flow filtration system for performing a fluidic process, such as concentrating of components contained in a fluid sample or for exchanging the solvent of the sample fluid, the system comprising: - a fluid channel having two ends (10, 11) and being formed by conduits (4, 5) allowing a bidirectional flow of the fluid sample through the channel; - a tangential flow filtration module (TFF-module) having a first fluid port, a second fluid port, a permeate outlet and a semipermeable membrane capable of separating the fluid sample into a retentate stream flowing through one of the ports (14, 15) and a permeate stream upon passage of the fluid of the sample through the semipermeable membrane and through the permeate outlet; - at least two pairs (8, 9) of piston pumps having each two piston pumps, each piston pump having a piston swept volume forming a reservoir (18, 19) being able to contain a fluid, the piston pumps being capable to drive a fluid flow; - the volume of the piston pumps of one pair of piston pumps (8a, 8b) is larger than the volume of the piston pumps of the other pair of piston pumps (9a, 9b), - a control unit for controlling the piston pumps, wherein - the TFF-module is located in the fluid channel so that one conduit is connected to the first fluid port and the other conduit is connected to the second fluid port to allow a fluid flowing through the channel to pass through the TFF-module; - at each of the ends (10, 11) of the channel one piston pump of each pair (8, 9) of piston pumps is arranged in such a manner that the piston pumps are fluidically connected; - the control unit is arranged and adapted to control driving of the piston pumps of each pair (8, 9) of piston pumps synchronously and/or to control the switching and/or the switching time for switching from one pair of piston pumps (8a, 8b) to the other pair of piston pumps (9a, 9b) and - the system is arranged and adapted such that during the fluidic process at least for a period of time only one of the pairs (8, 9) of piston pumps is used to drive the fluid flow through the fluid channel. - a fluid channel having two ends (10, 11) and being formed by conduits (4, 5) allowing a bidirectional flow of the fluid sample through the channel; - a tangential flow filtration module (TFF-module) having a first fluid port, a second fluid port, a permeate outlet and a semipermeable membrane capable of separating the fluid sample into a retentate stream flowing through one of the ports (14, 15) and a permeate stream upon passage of the fluid of the sample through the semipermeable membrane and through the permeate outlet; - at least two pairs (8, 9) of piston pumps having each two piston pumps, each piston pump having a piston swept volume forming a reservoir (18, 19) being able to contain a fluid, the piston pumps being capable to drive a fluid flow; - the volume of the piston pumps of one pair of piston pumps (8a, 8b) is larger than the volume of the piston pumps of the other pair of piston pumps (9a, 9b), - a control unit for controlling the piston pumps, wherein - the TFF-module is located in the fluid channel so that one conduit is connected to the first fluid port and the other conduit is connected to the second fluid port to allow a fluid flowing through the channel to pass through the TFF-module; - at each of the ends (10, 11) of the channel one piston pump of each pair (8, 9) of piston pumps is arranged in such a manner that the piston pumps are fluidically connected; - the control unit is arranged and adapted to control driving of the piston pumps of each pair (8, 9) of piston pumps synchronously and/or to control the switching and/or the switching time for switching from one pair of piston pumps (8a, 8b) to the other pair of piston pumps (9a, 9b) and - the system is arranged and adapted such that during the fluidic process at least for a period of time only one of the pairs (8, 9) of piston pumps is used to drive the fluid flow through the fluid channel.