A method for determining an analyte concentration in a physiological sample, the method comprising: (a) introducing the physiological sample into an electrochemical cell to initiate a reaction with a reagent in the cell, the electrochemical cell comprising first and second electrodes in a spaced apart relationship, the reagent layer comprising an enzyme and a mediator; (b) applying a first electric potential having a first polarity to the reaction cell and measuring cell current as a function of time to obtain a first time-current transient; (c) applying a second electric potential having a second polarity to the cell, wherein the second polarity is opposite the first polarity, and measuring cell current as a function of time to obtain a second time-current transient; and (d) calculating a first current value based on an integral of current values over a first time interval of the second time-current transient and a second current value based on an integral of current values over a second time interval of the second time-current transient, and calculating a third current value based on an integral of current values over a third time interval of the first time-current transient, wherein the first, second, and third time intervals are determined empirically such that the determined analyte concentration is accurate within ± 10% of a reference measurement, and has variation of 2 % at 1σ; (e) calculating a ratio which comprises the second current value divided by the third current value; (f) calculating a correction factor by setting the ratio to a power p; (g) multiplying the first current value less a background value by the correction factor to derive the analyte concentration. (a) introducing the physiological sample into an electrochemical cell to initiate a reaction with a reagent in the cell, the electrochemical cell comprising first and second electrodes in a spaced apart relationship, the reagent layer comprising an enzyme and a mediator; (b) applying a first electric potential having a first polarity to the reaction cell and measuring cell current as a function of time to obtain a first time-current transient; (c) applying a second electric potential having a second polarity to the cell, wherein the second polarity is opposite the first polarity, and measuring cell current as a function of time to obtain a second time-current transient; and (d) calculating a first current value based on an integral of current values over a first time interval of the second time-current transient and a second current value based on an integral of current values over a second time interval of the second time-current transient, and calculating a third current value based on an integral of current values over a third time interval of the first time-current transient, wherein the first, second, and third time intervals are determined empirically such that the determined analyte concentration is accurate within ± 10% of a reference measurement, and has variation of 2 % at 1σ; (e) calculating a ratio which comprises the second current value divided by the third current value; (f) calculating a correction factor by setting the ratio to a power p; (g) multiplying the first current value less a background value by the correction factor to derive the analyte concentration.