A device for the collection of biological samples, characterized by: - a cylindrical body with: - a proximal end; - a distal end; - a tab located inside the cylindrical body, between the proximal end and the distal end; - a stop located on the internal surface of the cylindrical body between the proximal end and the distal end; and - a ring located between the tab and the stop; - a rod located inside the cylindrical body, where the rod has: - a proximal tip; - a distal tip protruding from the distal end of the cylindrical body; - a flange located between the proximal tip and the distal tip; - a central section that extends between the distal tip of the rod and the proximal tip of the rod; - at least one longitudinal slot located in the central section and disposed on the axial axis of the rod; and - at least one protuberance located between the flange and the distal tip, and around the at least one longitudinal slot; and - a brush with a distal connection connected to the proximal tip of the rod; wherein when the rod moves longitudinally along the cylindrical body in the proximal direction, the rod connects the flange with the tab; wherein the rod is configured to move longitudinally along the cylindrical body in the distal direction causing first that the ring presses the at least one protuberance and elastically deforms the at least one longitudinal slot and then it causes the distal connection of the brush to collide against the stop of the cylindrical body, causing the brush to detach from the rod. - a cylindrical body with: - a proximal end; - a distal end; - a tab located inside the cylindrical body, between the proximal end and the distal end; - a stop located on the internal surface of the cylindrical body between the proximal end and the distal end; and - a ring located between the tab and the stop; - a proximal end; - a distal end; - a tab located inside the cylindrical body, between the proximal end and the distal end; - a stop located on the internal surface of the cylindrical body between the proximal end and the distal end; and - a ring located between the tab and the stop; - a rod located inside the cylindrical body, where the rod has: - a proximal tip; - a distal tip protruding from the distal end of the cylindrical body; - a flange located between the proximal tip and the distal tip; - a central section that extends between the distal tip of the rod and the proximal tip of the rod; - at least one longitudinal slot located in the central section and disposed on the axial axis of the rod; and - at least one protuberance located between the flange and the distal tip, and around the at least one longitudinal slot; and - a proximal tip; - a distal tip protruding from the distal end of the cylindrical body; - a flange located between the proximal tip and the distal tip; - a central section that extends between the distal tip of the rod and the proximal tip of the rod; - at least one longitudinal slot located in the central section and disposed on the axial axis of the rod; and - at least one protuberance located between the flange and the distal tip, and around the at least one longitudinal slot; and - a brush with a distal connection connected to the proximal tip of the rod; wherein when the rod moves longitudinally along the cylindrical body in the proximal direction, the rod connects the flange with the tab; wherein the rod is configured to move longitudinally along the cylindrical body in the distal direction causing first that the ring presses the at least one protuberance and elastically deforms the at least one longitudinal slot and then it causes the distal connection of the brush to collide against the stop of the cylindrical body, causing the brush to detach from the rod.