mhurhangee/ep-ind-claims huggingface dataset:
A method for preparing a sequencing library comprising nucleic acids from a plurality of single nuclei or cells, the method comprising: (a) providing a plurality of nuclei or cells in a first plurality of compartments, wherein each compartment comprises a subset of nuclei or cells; (b) labeling newly synthesized RNA in the subsets of cells or nuclei obtained from the cells; (c) processing RNA molecules in each subset of nuclei or cells to generate indexed nuclei or cells, wherein the processing comprises adding to RNA nucleic acids present in each subset of nuclei or cells a first compartment specific index sequence to result in indexed nucleic acids present in indexed nuclei or cells, wherein the processing comprises ligation, primer extension, hybridization, or amplification; and (d) combining the indexed nuclei or cells to generate pooled indexed nuclei or cells. (a) providing a plurality of nuclei or cells in a first plurality of compartments, wherein each compartment comprises a subset of nuclei or cells; (b) labeling newly synthesized RNA in the subsets of cells or nuclei obtained from the cells; (c) processing RNA molecules in each subset of nuclei or cells to generate indexed nuclei or cells, wherein the processing comprises adding to RNA nucleic acids present in each subset of nuclei or cells a first compartment specific index sequence to result in indexed nucleic acids present in indexed nuclei or cells, wherein the processing comprises ligation, primer extension, hybridization, or amplification; and wherein the processing comprises adding to RNA nucleic acids present in each subset of nuclei or cells a first compartment specific index sequence to result in indexed nucleic acids present in indexed nuclei or cells, wherein the processing comprises ligation, primer extension, hybridization, or amplification; and (d) combining the indexed nuclei or cells to generate pooled indexed nuclei or cells.
A compound of formula wherein A 1 is S or SO 2; A 2 is A 3 is cycloalkyl, substituted cycloalkyl, piperidinyl, substituted piperidinyl, tetrahydropyranyl, dimethyltetrahydropyranyl, tetrahydrothiopyranyl, morpholinyl, thiomoipholinyl, pyrrolidinyl, piperazinyl, substituted piperazinyl or azepanyl, wherein substituted cycloalkyl is cycloalkyl substituted with one or two substitutents independently selected from halogen and alkyl, wherein substituted piperidinyl is piperidinyl substituted with one substituent selected from alkyl, phenyl, 3-methyl-[1,2,4]thiadiazol-5-yl, acetyl, haloalkyl, alkoxycarbonyl and alkylsulfonyl or with two substituents independently selected from alkyl, and wherein substituted piperazinyl is piperazinyl substituted with one substituent selected from alkyl, alkoxycarbonyl, acetyl, formyl, alkylsulfonyl and haloalkylcarbonyl; and R 1, R 2 and R are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy and haloalkoxy; or a pharmaceutically acceptable salt or ester thereof. A 1 is S or SO 2; A 2 is A 3 is cycloalkyl, substituted cycloalkyl, piperidinyl, substituted piperidinyl, tetrahydropyranyl, dimethyltetrahydropyranyl, tetrahydrothiopyranyl, morpholinyl, thiomoipholinyl, pyrrolidinyl, piperazinyl, substituted piperazinyl or azepanyl, wherein substituted cycloalkyl is cycloalkyl substituted with one or two substitutents independently selected from halogen and alkyl, wherein substituted piperidinyl is piperidinyl substituted with one substituent selected from alkyl, phenyl, 3-methyl-[1,2,4]thiadiazol-5-yl, acetyl, haloalkyl, alkoxycarbonyl and alkylsulfonyl or with two substituents independently selected from alkyl, and wherein substituted piperazinyl is piperazinyl substituted with one substituent selected from alkyl, alkoxycarbonyl, acetyl, formyl, alkylsulfonyl and haloalkylcarbonyl; and R 1, R 2 and R are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy and haloalkoxy;
A transmission device comprising: a plurality of optical transmitters configured to transmit optical signals of different wavelengths (λ1 ∼ λ40); a plurality of optical couplers configured to multiplex the optical signals transmitted from the plurality of optical transmitters; a wavelength selective switch configured to multiplex multiplexed optical signals obtained by multiplexing by the plurality of optical couplers; a plurality of selecting units configured to select destinations of the optical signals transmitted from the plurality of optical transmitters to the plurality of optical couplers; and a control unit configured to acquire wavelengths of the optical signals, determine channel numbers (ch1 - ch40) assigned to the wavelengths in continuous sequence from the wavelengths, and control the plurality of selecting units based on the channel numbers so that the optical signals of neighboring channel numbers are transmitted to separate optical couplers of the plurality of optical couplers. a plurality of optical transmitters configured to transmit optical signals of different wavelengths (λ1 ∼ λ40); a plurality of optical couplers configured to multiplex the optical signals transmitted from the plurality of optical transmitters; a wavelength selective switch configured to multiplex multiplexed optical signals obtained by multiplexing by the plurality of optical couplers; a plurality of selecting units configured to select destinations of the optical signals transmitted from the plurality of optical transmitters to the plurality of optical couplers; and a control unit configured to acquire wavelengths of the optical signals, determine channel numbers (ch1 - ch40) assigned to the wavelengths in continuous sequence from the wavelengths, and control the plurality of selecting units based on the channel numbers so that the optical signals of neighboring channel numbers are transmitted to separate optical couplers of the plurality of optical couplers.
An apparatus for application of surgical clips to body tissue, the apparatus comprising: a handle assembly having a handle and a trigger moveable with respect to the handle; an elongated shaft extending distally from the handle assembly, the elongated shaft including a stack of surgical clips disposed therein, each surgical clip including a pair of legs (220a, 220b) connected to each other at one end by a crossbar, each of the pair of legs having an inwardly facing surface (222a,222b) and an outwardly facing surface (224a,224b); a jaw assembly disposed at a distal end of the elongated shaft, the jaw assembly including first and second opposed jaws (120a, 120b) moveable between a spaced apart position and an approximated position, each of the jaws defining a clip forming recess (122a,122b) extending longitudinally along opposing inner surfaces (121 a,121 b) thereof, characterized in that: the outwardly facing surface (224a,224b) of each of the pair of legs (220a,220b) of each said clip has a raised profile (226a,226b) protruding therefrom and extending longitudinally therealong; and a longitudinally extending groove (124a, 124b) having a profile complementary to the raised profile of the legs of the at least one surgical clip is formed within each said clip forming recess (122a,122b), wherein a pair of shoulders is defined at an interface between the recess (122a,122b) and the groove (124a, 124b) of each jaw at opposed sides of the groove; and wherein the legs (220a, 220b) of each of the surgical clips are positionable at least partially within respective grooves (124a,124b) of the clip forming recesses (122a,122b) of the jaws. a handle assembly having a handle and a trigger moveable with respect to the handle; an elongated shaft extending distally from the handle assembly, the elongated shaft including a stack of surgical clips disposed therein, each surgical clip including a pair of legs (220a, 220b) connected to each other at one end by a crossbar, each of the pair of legs having an inwardly facing surface (222a,222b) and an outwardly facing surface (224a,224b); a jaw assembly disposed at a distal end of the elongated shaft, the jaw assembly including first and second opposed jaws (120a, 120b) moveable between a spaced apart position and an approximated position, each of the jaws defining a clip forming recess (122a,122b) extending longitudinally along opposing inner surfaces (121 a,121 b) thereof, the outwardly facing surface (224a,224b) of each of the pair of legs (220a,220b) of each said clip has a raised profile (226a,226b) protruding therefrom and extending longitudinally therealong; and a longitudinally extending groove (124a, 124b) having a profile complementary to the raised profile of the legs of the at least one surgical clip is formed within each said clip forming recess (122a,122b), wherein a pair of shoulders is defined at an interface between the recess (122a,122b) and the groove (124a, 124b) of each jaw at opposed sides of the groove; and wherein the legs (220a, 220b) of each of the surgical clips are positionable at least partially within respective grooves (124a,124b) of the clip forming recesses (122a,122b) of the jaws.
A method comprising: receiving, at data processing hardware, a web page request for a web page; generating, by the data processing hardware, an attack payload for an injection vulnerability context of the web page based on a version of an interpreted programming language framework and an interpolation sign of the web page; instrumenting, by the data processing hardware, the web page to inject the attack payload by injecting the attack payload into one or more possible input vectors associated with the injection vulnerability context, wherein the one or more possible input vectors comprise at least one of: text boxes; uniform resource locators; buttons; or lists; executing, by the data processing hardware, the instrumented web page; catching, by the data processing hardware, a thrown exception triggered by the attack payload during execution of the instrumented web page; and identifying, by the data processing hardware, a vulnerability of the web page based on the thrown exception. receiving, at data processing hardware, a web page request for a web page; generating, by the data processing hardware, an attack payload for an injection vulnerability context of the web page based on a version of an interpreted programming language framework and an interpolation sign of the web page; instrumenting, by the data processing hardware, the web page to inject the attack payload by injecting the attack payload into one or more possible input vectors associated with the injection vulnerability context, wherein the one or more possible input vectors comprise at least one of: text boxes; uniform resource locators; buttons; or lists; executing, by the data processing hardware, the instrumented web page; catching, by the data processing hardware, a thrown exception triggered by the attack payload during execution of the instrumented web page; and identifying, by the data processing hardware, a vulnerability of the web page based on the thrown exception.
A double-sided cutting insert for corner milling, said cutting insert having a top surface; a bottom surface; a circumferential lateral face; a first cutting edge which is realized at a transition from the top surface to the circumferential lateral face; a second cutting edge which is realized at a transition from the bottom surface to the circumferential lateral face; an axis of symmetry with reference to which the cutting insert comprises a 4-fold rotational symmetry; and a reference plane which extends perpendicular to the axis of symmetry and divides the cutting insert into two halves; wherein the cutting insert has a substantially square-shaped basic form in a top view onto the top surface and the first cutting edge and the second cutting edge comprise in each case four cutting edge portions (20, 20', 20", 20"'), one cutting edge portion (20, 20', 20", 20"') comprises in each case a main edge (21, 21', 21", 21"') and a wiper edge (22, 22', 22", 22"'), both of which are connected together by means of an associated rounded cutting corner (23, 23', 23", 23"'), characterized in that the first and second cutting edges (14,15) are in each case at the greatest distance from the reference plane in the region of the cutting corners (23, 23', 23", 23"'), wherein a main clearance face (24, 24', 24", 24"') is realized in each case directly adjoining an assigned main edge (21, 21', 21", 21"') in the circumferential lateral face, wherein a wiper clearance face (25, 25', 25", 25"') is realized in each case directly adjoining an assigned wiper edge (22, 22', 22", 22"') in the circumferential lateral face, and wherein the exterior angles (ρ) formed between the main clearance faces (24, 24', 24", 24"') and the reference plane are greater than the exterior angles (σ) formed between the wiper clearance faces (25, 25', 25", 25"') and the reference plane.
- A process for producing maltitol, comprising: a) a step of producing a maltose syrup, referred to as "maltose syrup A", by hydrolysis of a granular starch, this step comprising a first stage of liquefaction of said granular starch by hydrolysis to form a liquefied starch, followed by a stage of saccharification of the liquefied starch to form the maltose syrup A; b) optionally subjecting the maltose syrup A to a step of concentration, of dilution, of enrichment in maltose, and/or of mixing with another starch hydrolyzate syrup to form another maltose syrup, referred to as "maltose syrup B"; c) a step of hydrogenation of the maltose syrup A or of the maltose syrup B to form an aqueous composition of maltitol, referred to as "maltitol composition C"; d) optionally subjecting the maltitol composition C to a step of concentration, of dilution, of enrichment in maltitol, and/or of mixing with an additional polyol syrup to form an aqueous maltitol composition, referred to as "maltitol composition D"; e) optionally a step of formation of maltitol powder from the maltitol composition C or from the maltitol composition D; f) a step of recovering the maltitol composition C, the maltitol composition D or the maltitol powder; wherein the stage of saccharification of the liquefied starch comprises the introduction, into the liquefied starch, of an aqueous solution of beta-amylase, also comprising: • from 0.05 to 0.5% of potassium sorbate; • from 30 to 50% of glycerol; • from 0.05 to 0.5% of sodium carbonate these percentages being expressed as percentage by dry weight of each constituent relative to the total weight of said aqueous solution. a) a step of producing a maltose syrup, referred to as "maltose syrup A", by hydrolysis of a granular starch, this step comprising a first stage of liquefaction of said granular starch by hydrolysis to form a liquefied starch, followed by a stage of saccharification of the liquefied starch to form the maltose syrup A; b) optionally subjecting the maltose syrup A to a step of concentration, of dilution, of enrichment in maltose, and/or of mixing with another starch hydrolyzate syrup to form another maltose syrup, referred to as "maltose syrup B"; c) a step of hydrogenation of the maltose syrup A or of the maltose syrup B to form an aqueous composition of maltitol, referred to as "maltitol composition C"; d) optionally subjecting the maltitol composition C to a step of concentration, of dilution, of enrichment in maltitol, and/or of mixing with an additional polyol syrup to form an aqueous maltitol composition, referred to as "maltitol composition D"; e) optionally a step of formation of maltitol powder from the maltitol composition C or from the maltitol composition D; f) a step of recovering the maltitol composition C, the maltitol composition D or the maltitol powder; • from 0.05 to 0.5% of potassium sorbate; • from 30 to 50% of glycerol; • from 0.05 to 0.5% of sodium carbonate
A knot tying device, suitable for realizing a knot of a tie comprising a narrower part and a wider part, said knot tying device comprising: - A ring defining an internal cavity of passage for the narrower part and an external surface of support for said wider part; characterised in that it further comprises: - At least one ferromagnetic body, integral to said ring; - At least one magnet suitable for resting on said wider part so as to substantially overlap to the ferromagnetic body, constraining itself to said ferromagnetic body and blocking said wider part to said ring. - A ring defining an internal cavity of passage for the narrower part and an external surface of support for said wider part; characterised in that it further comprises: - At least one ferromagnetic body, integral to said ring; - At least one magnet suitable for resting on said wider part so as to substantially overlap to the ferromagnetic body, constraining itself to said ferromagnetic body and blocking said wider part to said ring. - At least one ferromagnetic body, integral to said ring; - At least one magnet suitable for resting on said wider part so as to substantially overlap to the ferromagnetic body, constraining itself to said ferromagnetic body and blocking said wider part to said ring.
A process for the reduction of the content of residual monomeric isocyanate in a polyurethane prepolymer containing said residual monomeric isocyanate comprising the step of (i) contacting the polyurethane prepolymer with a porous material having pores formed by a framework containing isocyanate reactive functional groups at a temperature allowing chemical reaction of the reactive functional groups with the residual monomeric isocyanate in at least a fraction of the pores in order to covalently bind the reacted isocyanate, wherein the porous material is a porous metal-organic framework material comprising at least one metal ion and at least one at least bidentate organic compound, which is coordinately bound to said metal ion, wherein the polyurethane prepolymer is liquid with a viscosity in the range from 0.1 to 10 7 mPas, determined with a Haake-Mars rheometer with plate-plate geometry in rotation and 1 mm gap width at a shear rate of 10 and 40 s -1 at the temperature and wherein the ratio (w:w) of polyurethane prepolymer to porous material is in the range of from 100:0.1 to 100:50. (i) contacting the polyurethane prepolymer with a porous material having pores formed by a framework containing isocyanate reactive functional groups at a temperature allowing chemical reaction of the reactive functional groups with the residual monomeric isocyanate in at least a fraction of the pores in order to covalently bind the reacted isocyanate, wherein the porous material is a porous metal-organic framework material comprising at least one metal ion and at least one at least bidentate organic compound, which is coordinately bound to said metal ion, wherein the polyurethane prepolymer is liquid with a viscosity in the range from 0.1 to 10 7 mPas, determined with a Haake-Mars rheometer with plate-plate geometry in rotation and 1 mm gap width at a shear rate of 10 and 40 s -1 at the temperature and wherein the ratio (w:w) of polyurethane prepolymer to porous material is in the range of from 100:0.1 to 100:50.
A dental round blank holding ring, wherein the holding ring consists of at least two components (26, 28), characterized in that the harder one of which overlaps the softer one and in that the holding ring comprises a horizontally extending separation plane at which an upper part of the holding ring can be separated from a lower part of the holding ring, wherein the softer component consists of a thermoplastic elastomer or another plastic material with a Shore A hardness of less than 80, and that the holding ring comprises a vertically extending parting line which interrupts the holding ring at that point or a slit at which the holding ring can be spread open.
Screening basket for a screening bucket; said basket comprising a first cylindrical body having a central axis and a plurality of first holes arranged longitudinally at a first given pitch; a fluid-dynamic actuating unit being provided to rotate said first cylindrical body around said central axis; said basket comprising a second cylindrical body arranged inside said first cylindrical body and coupled to said first cylindrical body; said second cylindrical body having a plurality of second holes arranged longitudinally at a second given pitch and facing said first holes; actuating means being associated with said first and second cylindrical bodies to move them relative to each other; characterized in that said second cylindrical body is arranged inside said first cylindrical body in a longitudinally and angularly free manner, and in that said actuating means are so designed, that the rotation of one of the first and second cylindrical bodies through said actuating means results in a change in both the reciprocal position of the first and second cylindrical bodies along the longitudinal direction parallel to said central axis and in their reciprocal position in rotational direction, wherein therefore, by means of the actuating means, one of the two cylindrical bodies is both translated and rotated with respect to the other cylindrical body.
Method for manufacturing a support for an item of equipment comprising a main body covered with a coating, the method comprising: - a step of production of a mould comprising at least one impression which is concave and adapted to accommodate at least partially the item of equipment, characterized in that the mould being made from a digital model of the item of equipment, the digital model being made by computer-aided design software or obtained by digitizing an equipment, and that the method also includes - a step of liquid projection of a sealed elastomer material on to the mould to form the coating of the support, the coating comprising polyurea and being suitable to come into contact with the equipment, and - after coating hardening, a step of formation of the main body of the support on the coating. - a step of production of a mould comprising at least one impression which is concave and adapted to accommodate at least partially the item of equipment, characterized in that the mould being made from a digital model of the item of equipment, the digital model being made by computer-aided design software or obtained by digitizing an equipment, and that the method also includes - a step of liquid projection of a sealed elastomer material on to the mould to form the coating of the support, the coating comprising polyurea and being suitable to come into contact with the equipment, and - after coating hardening, a step of formation of the main body of the support on the coating.
An intelligent hub device, comprising a plurality of detector connectors configured to receive measurement signals from detectors intended to be connected thereto, and to output control signals to the detectors, at least one of the intended detectors comprising an array of individually addressable and readable sensors, controlling means configured to output for each of the plurality of detectors a corresponding control signal to induce each of the detectors to measure and output resulting measurement signals, including an array control signal to the array of individually addressable and readable sensors intended to address only a subset of these sensors such that these become the only sensors of the array to output array measurement signal to the hub, reading means configured to receive the output measurement signal and the array measurement signal, processing means configured to at least operate the controlling means, and com munication means configured to handle data communication of the processing means to an outside of the hub.