mhurhangee/ep-ind-claims huggingface dataset:
A compound represented by Formula: or a pharmaceutically acceptable salt thereof, wherein: Y is absent, -CR b R b -, -O-, -NR b -, -S n -; R 1 is phenyl, cyclopentyl, cyclohexyl, thienyl, pyridinyl, thiazolyl, pyrrolyl, imidazolyl, furanyl, oxazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, oxadiazolyl, tetrahydropyranyl, triazolyl, or thiadiazolyl, each of which is optionally substituted with 1 to 3 groups individually represented by R a; R 3 is monocyclic heterocyclyl or monocyclic heteroaryl, each of which is optionally substituted with 1 to 3 groups selected from -F, -CI, -Br, I, -CN, -NO 2, -OR b, -(C 1 -C 4)alkyl, -(C 1 -C 3)alkylene-OR b, -(C 1 -C 3)alkylene-NR b R b, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)haloalkoxy, -(C 3 -C 8)cycloalkyl, -NR b R b, -C(=O)NR b R b, -NR b (C=O)NR b R b, -S n NR b R b, C(=O)OR b, -OC(=O)OR b, -S n R b, -NR b S n R b, -C(=S)OR b, -O(C=S)R b, -NR b C(=O)R b,-C(=S)NR b R b, -NR b C(=S)R b, -NR b (C=O)OR b, -O(C=O)NR b R b, -NR b (C=S)OR b, O(C=S)NR b R b, -NR b (C=S)NR b R b, -C(=S)R b and -C(=O)R b; each R 4 is independently selected from -F, -CI, -Br, I, -CN, -NR b R b, -OR b, -C 1 -C 4 alkyl, -(C 1 -C 3)alkylene-OR b, -(C 1 -C 3)alkylene-NR b R b, -C 1 -C 4 haloalkyl, and -C 1 -C 4 haloalkoxy; each R a is independently selected from -F, -CI, -Br, I, -CN, OR b, -(C 1 -C 4)alkyl, -(C 2 -C 6)alkenyl, -(C 2 -C 6)alkynyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)haloalkoxy, -(C 1 -C 3)alkylene-OR b, and -(C 1 -C 3)alkylene-NR b R b; each R b is independently -H or -C 1 -C 4 alkyl; each m is independently 0, 1, 2, or 3; and each n is independently 0, 1, or 2. Y is absent, -CR b R b -, -O-, -NR b -, -S n -; R 1 is phenyl, cyclopentyl, cyclohexyl, thienyl, pyridinyl, thiazolyl, pyrrolyl, imidazolyl, furanyl, oxazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, oxadiazolyl, tetrahydropyranyl, triazolyl, or thiadiazolyl, each of which is optionally substituted with 1 to 3 groups individually represented by R a; R 3 is monocyclic heterocyclyl or monocyclic heteroaryl, each of which is optionally substituted with 1 to 3 groups selected from -F, -CI, -Br, I, -CN, -NO 2, -OR b, -(C 1 -C 4)alkyl, -(C 1 -C 3)alkylene-OR b, -(C 1 -C 3)alkylene-NR b R b, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)haloalkoxy, -(C 3 -C 8)cycloalkyl, -NR b R b, -C(=O)NR b R b, -NR b (C=O)NR b R b, -S n NR b R b, C(=O)OR b, -OC(=O)OR b, -S n R b, -NR b S n R b, -C(=S)OR b, -O(C=S)R b, -NR b C(=O)R b,-C(=S)NR b R b, -NR b C(=S)R b, -NR b (C=O)OR b, -O(C=O)NR b R b, -NR b (C=S)OR b, O(C=S)NR b R b, -NR b (C=S)NR b R b, -C(=S)R b and -C(=O)R b; each R 4 is independently selected from -F, -CI, -Br, I, -CN, -NR b R b, -OR b, -C 1 -C 4 alkyl, -(C 1 -C 3)alkylene-OR b, -(C 1 -C 3)alkylene-NR b R b, -C 1 -C 4 haloalkyl, and -C 1 -C 4 haloalkoxy; each R a is independently selected from -F, -CI, -Br, I, -CN, OR b, -(C 1 -C 4)alkyl, -(C 2 -C 6)alkenyl, -(C 2 -C 6)alkynyl, -(C 1 -C 4)haloalkyl, -(C 1 -C 4)haloalkoxy, -(C 1 -C 3)alkylene-OR b, and -(C 1 -C 3)alkylene-NR b R b; each R b is independently -H or -C 1 -C 4 alkyl; each m is independently 0, 1, 2, or 3; and each n is independently 0, 1, or 2.
Module for directory-based cache coherence management in a multiprocessor system implementing an eviction mechanism, in which each data item stored in cache memory is associated with a state from among a plurality of states, at least one of which is a first state reflecting data sharing between a plurality of processors comprising: - a storage unit for storing a directory comprising a list of cache memory addresses, it being possible for each address to be associated with a state from among a plurality of states corresponding to the state of the data item available at each address, and - a processing unit configured to update said list, said processing unit being configured in order not to list in said list, the address lines that are relative to data associated with said first state reflecting data sharing between a plurality of processors, characterized in that the processing unit is configured to operate selectively in at least two modes: - a first operating mode in which the address lines associated with said first state are not listed in said list, and - a second operating mode in which the address lines associated with said first state are listed in said list; in that the processing unit is furthermore configured to implement an eviction mechanism for an address line of said directory, and in that the data item associated with the first state is an instruction pre-loaded by a plurality of processors. - a storage unit for storing a directory comprising a list of cache memory addresses, it being possible for each address to be associated with a state from among a plurality of states corresponding to the state of the data item available at each address, and - a processing unit configured to update said list, said processing unit being configured in order not to list in said list, the address lines that are relative to data associated with said first state reflecting data sharing between a plurality of processors, - a first operating mode in which the address lines associated with said first state are not listed in said list, and - a second operating mode in which the address lines associated with said first state are listed in said list; in that the processing unit is furthermore configured to implement an eviction mechanism for an address line of said directory, and in that the data item associated with the first state is an instruction pre-loaded by a plurality of processors.
A medication delivery and control system comprising: (a) an apparatus comprising at least one photoplethysmography, PPG, sensor (301, 302), wherein the apparatus is configured to secure to a subject's nose; (b) an infusion device that is configured to provide medication to the subject's nose; (c) a controller for receiving PPG signals from the PPG sensor and, based on the signals, increasing, decreasing or maintaining a rate of infusion of the infusion device; and (d) an accelerometer or other motion sensing device configured to be worn on the subject's head, wherein when the accelerometer or other motion sensing device receives signals that the subject is actively moving, the system enters a sleep mode wherein power consumption is reduced, wherein the medication delivery control system is a wearable device adapted to secure to the nose and/or head of the subject. (a) an apparatus comprising at least one photoplethysmography, PPG, sensor (301, 302), wherein the apparatus is configured to secure to a subject's nose; (b) an infusion device that is configured to provide medication to the subject's nose; (c) a controller for receiving PPG signals from the PPG sensor and, based on the signals, increasing, decreasing or maintaining a rate of infusion of the infusion device; and (d) an accelerometer or other motion sensing device configured to be worn on the subject's head, wherein when the accelerometer or other motion sensing device receives signals that the subject is actively moving, the system enters a sleep mode wherein power consumption is reduced, wherein the medication delivery control system is a wearable device adapted to secure to the nose and/or head of the subject.
A method, comprising: providing a rigid cylindrical probe having a distal end; fastening a rigid gripper (36, 136) around the cylindrical probe; fixedly attaching a sensor to the rigid gripper, wherein the sensor is configured to generate a sensor signal indicative of a location of the gripper; attaching a pair of conductors (62, 66, 148, 150) to the gripper so as to make contact with one another or be electrically connected to one another, while the gripper is fastened around the cylindrical probe, at a location along a length of the conductors that varies responsively to a diameter of the cylindrical probe; receiving a computerized tomography scan of a patient, registering an image of the patient derived from the scan with the magnetic tracking system, measuring an impedance of a current passing through the pair of conductors; generating an indication of the diameter responsively to the impedance; and while the distal end is in contact with the patient, formulating a metric of a location of the distal end responsively to the indication of the diameter and the sensor signal. providing a rigid cylindrical probe having a distal end; fastening a rigid gripper (36, 136) around the cylindrical probe; fixedly attaching a sensor to the rigid gripper, wherein the sensor is configured to generate a sensor signal indicative of a location of the gripper; attaching a pair of conductors (62, 66, 148, 150) to the gripper so as to make contact with one another or be electrically connected to one another, while the gripper is fastened around the cylindrical probe, at a location along a length of the conductors that varies responsively to a diameter of the cylindrical probe; receiving a computerized tomography scan of a patient, registering an image of the patient derived from the scan with the magnetic tracking system, measuring an impedance of a current passing through the pair of conductors; generating an indication of the diameter responsively to the impedance; and while the distal end is in contact with the patient, formulating a metric of a location of the distal end responsively to the indication of the diameter and the sensor signal.
A bearing comprising: a generally cylindrical sidewall defining first and second axial ends (104, 106) and an aperture extending between the first and second axial ends (104, 106), and a gap extending between the first and the second axial ends (104, 106); a flange extending radially from the generally cylindrical sidewall at a location proximate the first axial end; and a feature extending radially from the generally cylindrical sidewall at a location disposed between the flange and the second axial end, wherein the generally cylindrical sidewall comprises a low friction material, and wherein the flange comprises an engagement feature circumferentially offset from the gap, wherein the engagement feature comprises a projecting element, a corrugation, a ridge, a dimple, or a tine projecting from the flange. a generally cylindrical sidewall defining first and second axial ends (104, 106) and an aperture extending between the first and second axial ends (104, 106), and a gap extending between the first and the second axial ends (104, 106); a flange extending radially from the generally cylindrical sidewall at a location proximate the first axial end; and a feature extending radially from the generally cylindrical sidewall at a location disposed between the flange and the second axial end, wherein the generally cylindrical sidewall comprises a low friction material, and wherein the flange comprises an engagement feature circumferentially offset from the gap, wherein the engagement feature comprises a projecting element, a corrugation, a ridge, a dimple, or a tine projecting from the flange.
Machine for emptying cans automatically and hygienically, the machine comprising an extraction pipe, linked to a first support, upon which it is displaced, said first support being linked to an extender, mounted to a second support, along which the said extender is movable vertically and horizontally characterized in that the machine also has a number of bag fastening and closure means, these being linked to the said extender and the fastening and closure means being displaced alongside the extender in order to lift the bag to improve the product extraction of the said bag; the extraction pipe has an drainage channel, which runs along the centre of the extraction pipe, at the free end of which there is a displaceable cone, which fits on the output of the extraction pipe, it also has an internal sleeve and another external sleeve arranged concentrically to the former, the said internal sleeve has a ring shaped evacuation opening which is directed towards the inside of the drainage channel and the said external sleeve has a ring shaped evacuation channel, which evacuates or projects the water towards the outside of the extraction pipe.
A display device, arranged to receive motion image data from different sources on a network to which it is connectable, the device comprising: a display unit configured to reproduce motion image data from a source among the different sources, and to provide mode information relating to an execution state of said motion image data; a storage unit that stores a criterion for aborting a reproduction of motion image data reproduced by the display unit according to the mode information of a respective motion image data being provided for reproduction; and a determination unit that, in response to a display start request to display other motion image data from another source among the different sources connected to the display via the network, is configured to determine whether to abort the reproduction of the motion image data or not based on the criterion for aborting a reproduction of motion image data stored in the storage unit the display device being configured to cause the display unit to display the other motion image data, after the reproduction of the motion image data being provided for reproduction has been aborted. a display unit configured to reproduce motion image data from a source among the different sources, and to provide mode information relating to an execution state of said motion image data; a storage unit that stores a criterion for aborting a reproduction of motion image data reproduced by the display unit according to the mode information of a respective motion image data being provided for reproduction; and a determination unit that, in response to a display start request to display other motion image data from another source among the different sources connected to the display via the network, is configured to determine whether to abort the reproduction of the motion image data or not based on the criterion for aborting a reproduction of motion image data stored in the storage unit the display device being configured to cause the display unit to display the other motion image data, after the reproduction of the motion image data being provided for reproduction has been aborted.
A solid support composition comprising: a biocompatible solid support; at least one binding agent selected from the group consisting of trans -cyclooctene, tetrazine, azide, or alkyne; and a linker comprising a structure selected from the group consisting of: covalently linking each binding agent to the biocompatible solid support. a biocompatible solid support; at least one binding agent selected from the group consisting of trans -cyclooctene, tetrazine, azide, or alkyne; and a linker comprising a structure selected from the group consisting of: covalently linking each binding agent to the biocompatible solid support.
A method to be executed by a base station for improving a handover of a user equipment in a cell of a mobile communication system, the base station acting as relaying system between the user equipment and another base station, comprising: transmitting information to disable neighbor cell measurements of the user equipment inside the coverage area of the cell; periodically determining a position of the user equipment inside a coverage area of the cell based on an angle of arrival of a signal received from the user equipment; and transmitting information to the user equipment to enable neighbor cell measurements if a change of the periodically determined position indicates an exiting of the coverage area of the cell by the user equipment to improve a handover process to another cell. transmitting information to disable neighbor cell measurements of the user equipment inside the coverage area of the cell; periodically determining a position of the user equipment inside a coverage area of the cell based on an angle of arrival of a signal received from the user equipment; and transmitting information to the user equipment to enable neighbor cell measurements if a change of the periodically determined position indicates an exiting of the coverage area of the cell by the user equipment to improve a handover process to another cell.
A gas turbine engine, comprising: a sealing assembly that includes: a non-contacting seal; a ring constructed as a full ring and configured as a carrier of the seal; a sealing land configured to rotate and interface to the seal, characterised in that the ring is floating, the seal being a non-contacting seal with respect to the sealing land. a non-contacting seal; a ring constructed as a full ring and configured as a carrier of the seal; a sealing land configured to rotate and interface to the seal, characterised in that the ring is floating, the seal being a non-contacting seal with respect to the sealing land.
An inertial sensor, comprising: a planar mechanical resonator configured for substantially in-plane solid disc vibration with two isolated and degenerate resonator modes for Coriolis sensing having a central mounting point; a rigid support for the planar mechanical resonator at the central mounting point; a plurality of excitation electrodes within an interior of the planar mechanical resonator to excite in-plane vibration of the isolated and degenerate resonator modes; at least one sensing electrode within the interior of the planar mechanical resonator for sensing the vibration of the isolated and degenerate resonator modes; wherein the planar mechanical resonator comprises a plurality of slots, arranged in an annular pattern around the central mounting point, wherein the excitation electrodes are disposed within the plurality of slots (116; 122), characterized in that the slots including the excitation electrodes are arranged circumferentially interleaving with each other. a planar mechanical resonator configured for substantially in-plane solid disc vibration with two isolated and degenerate resonator modes for Coriolis sensing having a central mounting point; a rigid support for the planar mechanical resonator at the central mounting point; a plurality of excitation electrodes within an interior of the planar mechanical resonator to excite in-plane vibration of the isolated and degenerate resonator modes; at least one sensing electrode within the interior of the planar mechanical resonator for sensing the vibration of the isolated and degenerate resonator modes; wherein the planar mechanical resonator comprises a plurality of slots, arranged in an annular pattern around the central mounting point, wherein the excitation electrodes are disposed within the plurality of slots (116; 122), characterized in that the slots including the excitation electrodes are arranged circumferentially interleaving with each other.
An apparatus for suppressing a pathologically synchronous and oscillatory neuronal activity comprising - a non-invasive stimulation unit for stimulating neurons in the brain and/or spinal cord of the patient that exhibit a pathologically synchronous and oscillatory neuronal activity, using stimuli, wherein the stimuli are adapted to suppress the pathologically synchronous and oscillatory neuronal activity via an administration to the patient; - a measuring unit for recording measured signals which reproduce a neuronal activity of the stimulated neurons; and - a control and analysis unit for controlling the stimulation unit and for analyzing the measured signals, wherein the control and analysis unit is configured such that it - controls the stimulation unit such that the stimulation unit applies stimuli; - checks the stimulation success with reference to the measured signals recorded in response to the application of the stimuli; and, - if the stimulation success is not sufficient, inserts one or more stimulation breaks into the application of the stimuli or extends one or more stimulation breaks, wherein no stimuli are applied during the stimulation breaks that can suppress the pathologically synchronous and oscillatory neuronal activity. - a non-invasive stimulation unit for stimulating neurons in the brain and/or spinal cord of the patient that exhibit a pathologically synchronous and oscillatory neuronal activity, using stimuli, wherein the stimuli are adapted to suppress the pathologically synchronous and oscillatory neuronal activity via an administration to the patient; - a measuring unit for recording measured signals which reproduce a neuronal activity of the stimulated neurons; and - a control and analysis unit for controlling the stimulation unit and for analyzing the measured signals, wherein the control and analysis unit is configured such that it - controls the stimulation unit such that the stimulation unit applies stimuli; - checks the stimulation success with reference to the measured signals recorded in response to the application of the stimuli; and, - if the stimulation success is not sufficient, inserts one or more stimulation breaks into the application of the stimuli or extends one or more stimulation breaks, wherein no stimuli are applied during the stimulation breaks that can suppress the pathologically synchronous and oscillatory neuronal activity.
Turbine engine, comprising one single rotating body comprising a compressor rotor and a turbine rotor interconnected by a rotor shaft, the turbine engine being configured to drive a member by said shaft via an epicyclic reduction gear, said reduction gear comprising at least one first element rotationally secured to said shaft, at least one second element configured to be rotationally secured to said member, and at least one third element configured to be selectively secured to a stator of the turbine engine and disconnected from said stator, said turbine engine comprising the means (82, 84) to rotationally drive said third member configured to drive said third element at a piloted speed when it is disconnected from said stator, characterised in that said third element is connected to said stator by braking means, and in that said driving means comprise mechanical connection means to said third element, and mechanical retrieval means (85, 86) of the power from said turbine engine or from a source external to the turbine engine, the driving means being configured so that the power retrieved by the retrieval means is transmitted by the connection means to said third element, for the purpose of rotationally driving said third element.