A compound having the structure of Formula: or a pharmaceutically acceptable salt thereof, wherein: (a) NHE is a NHE-inhibiting small molecule moiety having the following structure of Formula: wherein: each R 1, R 2, R 3, R 5 and R 9 are independently selected from H, halogen, -NR 7 R 8, - NR 7 R 8, -SO 2 -NR 7 R 8, -NR 7 SO 2 R 8, -NR 7 R 8, -OR 7, -SR 7, -O NR 7 R 8, -NR 7 OR 8, and -NR 7 SO 2 NR 8, where R 7 and R 8 are independently selected from H, C 1-6 alkyl, -C 1-6 alkyl-OH or a bond linking the NHE-inhibiting small molecules to L, provided at least one is a bond linking the NHE-inhibiting small molecule to L; R 4 is selected from H, C 1 -C 7 alkyl, or a bond linking the NHE-inhibiting small molecule to L; R 6 is absent or selected from H and C 1 -C 7 alkyl; and Ar1 and Ar2 independently represent an aromatic ring or a heteroaromatic ring; (b) Core is a Core moiety having the following structure of Formula: wherein: X is selected from C(X 1), N and N(C 1-6 alkyl); X 1 is selected from hydrogen, optionally substituted alkyl, -NX a X b, -NO 2, -NX c -C(=O)-NX c -X a, -C(=O)NX c -X a, -NX c -C(=O)-X a, -NX c -SO 2 -X a, -C(=O)-X a and -OX a, each X a and X b are independently selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; Y is C 1-6 alkylene; Z is selected from -NZ a -C(=O)-NZ a -, -C(=O)NZ a -, -NZ a -C(=O)- and heteroaryl) when X is CX 1; Z is selected from -NZ a -C(=O)-NZ a -, and heteroaryl when X is N or N(C 1-6 alkyl); and each X c and Z a is independently selected from hydrogen and C 1-6 alkyl; and (c) L is a polyethylene glycol linker connecting the Core moiety to the NHE-inhibiting small molecule moieties. (a) NHE is a NHE-inhibiting small molecule moiety having the following structure of Formula: wherein: each R 1, R 2, R 3, R 5 and R 9 are independently selected from H, halogen, -NR 7 R 8, - NR 7 R 8, -SO 2 -NR 7 R 8, -NR 7 SO 2 R 8, -NR 7 R 8, -OR 7, -SR 7, -O NR 7 R 8, -NR 7 OR 8, and -NR 7 SO 2 NR 8, where R 7 and R 8 are independently selected from H, C 1-6 alkyl, -C 1-6 alkyl-OH or a bond linking the NHE-inhibiting small molecules to L, provided at least one is a bond linking the NHE-inhibiting small molecule to L; R 4 is selected from H, C 1 -C 7 alkyl, or a bond linking the NHE-inhibiting small molecule to L; R 6 is absent or selected from H and C 1 -C 7 alkyl; and Ar1 and Ar2 independently represent an aromatic ring or a heteroaromatic ring; each R 1, R 2, R 3, R 5 and R 9 are independently selected from H, halogen, -NR 7 R 8, - NR 7 R 8, -SO 2 -NR 7 R 8, -NR 7 SO 2 R 8, -NR 7 R 8, -OR 7, -SR 7, -O NR 7 R 8, -NR 7 OR 8, and -NR 7 SO 2 NR 8, where R 7 and R 8 are independently selected from H, C 1-6 alkyl, -C 1-6 alkyl-OH or a bond linking the NHE-inhibiting small molecules to L, provided at least one is a bond linking the NHE-inhibiting small molecule to L; R 4 is selected from H, C 1 -C 7 alkyl, or a bond linking the NHE-inhibiting small molecule to L; R 6 is absent or selected from H and C 1 -C 7 alkyl; and Ar1 and Ar2 independently represent an aromatic ring or a heteroaromatic ring; (b) Core is a Core moiety having the following structure of Formula: wherein: X is selected from C(X 1), N and N(C 1-6 alkyl); X 1 is selected from hydrogen, optionally substituted alkyl, -NX a X b, -NO 2, -NX c -C(=O)-NX c -X a, -C(=O)NX c -X a, -NX c -C(=O)-X a, -NX c -SO 2 -X a, -C(=O)-X a and -OX a, each X a and X b are independently selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; Y is C 1-6 alkylene; Z is selected from -NZ a -C(=O)-NZ a -, -C(=O)NZ a -, -NZ a -C(=O)- and heteroaryl) when X is CX 1; Z is selected from -NZ a -C(=O)-NZ a -, and heteroaryl when X is N or N(C 1-6 alkyl); and each X c and Z a is independently selected from hydrogen and C 1-6 alkyl; and X is selected from C(X 1), N and N(C 1-6 alkyl); X 1 is selected from hydrogen, optionally substituted alkyl, -NX a X b, -NO 2, -NX c -C(=O)-NX c -X a, -C(=O)NX c -X a, -NX c -C(=O)-X a, -NX c -SO 2 -X a, -C(=O)-X a and -OX a, each X a and X b are independently selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl; Y is C 1-6 alkylene; Z is selected from -NZ a -C(=O)-NZ a -, -C(=O)NZ a -, -NZ a -C(=O)- and heteroaryl) when X is CX 1; Z is selected from -NZ a -C(=O)-NZ a -, and heteroaryl when X is N or N(C 1-6 alkyl); and each X c and Z a is independently selected from hydrogen and C 1-6 alkyl; and (c) L is a polyethylene glycol linker connecting the Core moiety to the NHE-inhibiting small molecule moieties.