A peptide amphiphile lipid micelle-cargo (PALM-cargo) composition comprising: a) a peptide that comprises the amino acid sequence: X1- X2 -X3- X4 -X5 -X6 -X7 -X8 - X9 -X10 -X11 -X12 -X13 -X14 -X15 -X16 -X17 -X18- X19 -X20, wherein: X1 is the amino acid D; X2 and X20 are each the amino acid V; X3, X6, X10 and X13 are each an amino acid independently selected from the group consisting of L and F; X4, X12 and X19 are each the amino acid Q; X5 is an amino acid A or Aib; X7, X16 and X18 are each the amino acid K; X8 and X15 are each the amino acid E; X9 and X14 are each an amino acid independently selected from the group consisting of A, L, F and Aib; X11 is an amino acid selected from the group consisting of A, Aib and N; and X17 is an amino acid selected from the group consisting of W, F and L (SEQ ID NO:1); or X1-X2-X3-X4 -X5 -X6 -X7 -X8 -X9 -X10 -X11 -X12 -X13 -X14 -X15-X16 -X17 -X18- X19 - X20, wherein: X1 is an amino acid selected from the group consisting of D and E; X2 and X20 are each an amino acid independently selected from the group consisting of V, I, and L; X3, X6, X10 and X13 are each an amino acid independently selected from the group consisting of L, I, V, W, Y, Aib, Amv and F; X4, X12 and X19 are each an amino acid independently selected from the group consisting of Q and N; X5, X16 and X18 are each an amino acid independently selected from the group consisting of K, R, H and Orn; X7 is selected from the group consisting of A, G, S, V, Aib and Amv; X8 and X15 are independently selected from the group consisting of the amino acid E and D; X9 and X14 are an amino acid independently selected from the group consisting of A, G, S L, F, V, Amv, and Aib; X11 is an amino acid selected from the group consisting of A, G, S, Aib, Amv, V and N; and X17 is an amino acid selected from the group consisting of W, F, Y, I, V, and L (SEQ ID NO:24); wherein the peptide is optionally acylated at the N-terminus, amidated at the C-terminus, or both acylated at the N-terminus and amidated at the C-terminus and the peptide is from 20 to 24 amino acids in length; b) a lipid component comprising sphingomyelin and one or more additional phospholipids; and c) a cargo molecule that is a compound conjugate having the formula: A-R-L-X (formula I) wherein A is an agent having a hydroxyl or amine group; R is a hydroxyl or an amine group of the agent; L is a linker, and X is an anchor moiety. a) a peptide that comprises the amino acid sequence: X1- X2 -X3- X4 -X5 -X6 -X7 -X8 - X9 -X10 -X11 -X12 -X13 -X14 -X15 -X16 -X17 -X18- X19 -X20, wherein: X1 is the amino acid D; X2 and X20 are each the amino acid V; X3, X6, X10 and X13 are each an amino acid independently selected from the group consisting of L and F; X4, X12 and X19 are each the amino acid Q; X5 is an amino acid A or Aib; X7, X16 and X18 are each the amino acid K; X8 and X15 are each the amino acid E; X9 and X14 are each an amino acid independently selected from the group consisting of A, L, F and Aib; X11 is an amino acid selected from the group consisting of A, Aib and N; and X17 is an amino acid selected from the group consisting of W, F and L (SEQ ID NO:1); or X1-X2-X3-X4 -X5 -X6 -X7 -X8 -X9 -X10 -X11 -X12 -X13 -X14 -X15-X16 -X17 -X18- X19 - X20, wherein: X1 is an amino acid selected from the group consisting of D and E; X2 and X20 are each an amino acid independently selected from the group consisting of V, I, and L; X3, X6, X10 and X13 are each an amino acid independently selected from the group consisting of L, I, V, W, Y, Aib, Amv and F; X4, X12 and X19 are each an amino acid independently selected from the group consisting of Q and N; X5, X16 and X18 are each an amino acid independently selected from the group consisting of K, R, H and Orn; X7 is selected from the group consisting of A, G, S, V, Aib and Amv; X8 and X15 are independently selected from the group consisting of the amino acid E and D; X9 and X14 are an amino acid independently selected from the group consisting of A, G, S L, F, V, Amv, and Aib; X11 is an amino acid selected from the group consisting of A, G, S, Aib, Amv, V and N; and X17 is an amino acid selected from the group consisting of W, F, Y, I, V, and L (SEQ ID NO:24); wherein the peptide is optionally acylated at the N-terminus, amidated at the C-terminus, or both acylated at the N-terminus and amidated at the C-terminus and the peptide is from 20 to 24 amino acids in length; b) a lipid component comprising sphingomyelin and one or more additional phospholipids; and c) a cargo molecule that is a compound conjugate having the formula: A-R-L-X (formula I) wherein A is an agent having a hydroxyl or amine group; R is a hydroxyl or an amine group of the agent; L is a linker, and X is an anchor moiety.