An oral composition, comprising: a. a polyguanidine compound of Formula: wherein: X denotes an orally acceptable counterion; ZisCHorN; R 1, R 2, and R 3 are each independently a hydrogen or a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; A denotes a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; or A denotes a linear or branched, saturated or unsaturated, C 1 to C 16 alkylene radical optionally substituted with at least one radical selected from the group consisting of: a hydroxyl, carboxyl, or carboxylate radical or a halogen; the alkylene radical optionally containing at least one function group selected from the group consisting of: an amine, ether, thioether, ester, amide, carbamate, urea, C 6 aryl or C 3 to C 8 cyclanyl ring optionally substituted with a C 1 -C 8 alkyl, hydroxyl or halogen; or A denotes one or more C 6 or C 7 aryl or C 5 to C 7 cyclanyl rings unsubstituted or substituted with a C 1 -C 8 alkyl, a hydroxyl group or a halogen; or A denotes a C 10 to C 14 polyaryl or C 6 to C 10 polycyclanyl chain, which may be interrupted with at least one function group selected from the group consisting of: a C 1 to C 8 alkylene radical, amine, amide, ether, thioether, hydrogen atom, carbamate or urea; n denotes an integer between 2 and 5,000; and b. an orally acceptable carrier; c. a bioacceptable glass composition comprising 40-60 wt% SiO 2, 10-30 wt% CaO, 10-35 wt% Na 2 O, 2-8 wt% P 2 O 5, 0-25 wt% CaF 2, and 0-10 wt% B 2 O 3; and d. a small particle silica having an average particle size of 0.01 μm -100 μm. a. a polyguanidine compound of Formula: wherein: X denotes an orally acceptable counterion; ZisCHorN; R 1, R 2, and R 3 are each independently a hydrogen or a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; A denotes a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; or A denotes a linear or branched, saturated or unsaturated, C 1 to C 16 alkylene radical optionally substituted with at least one radical selected from the group consisting of: a hydroxyl, carboxyl, or carboxylate radical or a halogen; the alkylene radical optionally containing at least one function group selected from the group consisting of: an amine, ether, thioether, ester, amide, carbamate, urea, C 6 aryl or C 3 to C 8 cyclanyl ring optionally substituted with a C 1 -C 8 alkyl, hydroxyl or halogen; or A denotes one or more C 6 or C 7 aryl or C 5 to C 7 cyclanyl rings unsubstituted or substituted with a C 1 -C 8 alkyl, a hydroxyl group or a halogen; or A denotes a C 10 to C 14 polyaryl or C 6 to C 10 polycyclanyl chain, which may be interrupted with at least one function group selected from the group consisting of: a C 1 to C 8 alkylene radical, amine, amide, ether, thioether, hydrogen atom, carbamate or urea; n denotes an integer between 2 and 5,000; and X denotes an orally acceptable counterion; ZisCHorN; R 1, R 2, and R 3 are each independently a hydrogen or a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; A denotes a linear or branched, saturated or unsaturated, optionally hydroxylated C 1 to C 16 alkyl radical; or A denotes a linear or branched, saturated or unsaturated, C 1 to C 16 alkylene radical optionally substituted with at least one radical selected from the group consisting of: a hydroxyl, carboxyl, or carboxylate radical or a halogen; the alkylene radical optionally containing at least one function group selected from the group consisting of: an amine, ether, thioether, ester, amide, carbamate, urea, C 6 aryl or C 3 to C 8 cyclanyl ring optionally substituted with a C 1 -C 8 alkyl, hydroxyl or halogen; or A denotes one or more C 6 or C 7 aryl or C 5 to C 7 cyclanyl rings unsubstituted or substituted with a C 1 -C 8 alkyl, a hydroxyl group or a halogen; or A denotes a C 10 to C 14 polyaryl or C 6 to C 10 polycyclanyl chain, which may be interrupted with at least one function group selected from the group consisting of: a C 1 to C 8 alkylene radical, amine, amide, ether, thioether, hydrogen atom, carbamate or urea; n denotes an integer between 2 and 5,000; and b. an orally acceptable carrier; c. a bioacceptable glass composition comprising 40-60 wt% SiO 2, 10-30 wt% CaO, 10-35 wt% Na 2 O, 2-8 wt% P 2 O 5, 0-25 wt% CaF 2, and 0-10 wt% B 2 O 3; and d. a small particle silica having an average particle size of 0.01 μm -100 μm.