A compound of the Formula: wherein: R 1 is selected from the group consisting of H, straight-chain or branched (C 1 -C 6)alkyl, HC -, and (C 1 -C 6)alkyl-C -; R 2 and R 3 are each independently selected from hydrogen, straight-chain or branched (C 1 -C 6)alkyl or (C 1 -C 6)alkyl-C -, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form a 4-, 5-, 6- or 7- membered ring that is fully saturated, or partially saturated, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form a diester of the boronic acid and polyalcohols selected from: pinanediol, mannitol, glycerol, xylitol, sorbitol, or erythritol, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form an anhydride or mixed ester-anhydride of the boronic acid and hydroxy acids or di-carboxylic acids selected from: iminodiacetic acid or N- methyliminodiacetic acid or oxalic acid or tartaric acid or citric acid or malic acid or malonic acid or mandelic acid or glycolic acid or lactic acid or 3-hydroxypropionic acid; R 4 is selected from the group consisting of H, straight-chain and branched (C 1 -C 6)alkyl; R 5 is selected from the group consisting of H, F, methyl, ethyl, propyl, isopropyl, -CH 2 NH 2, -CH 2 NHCH 3, -CH 2 NHCH 2 CH 3, -CH 2 NHCH(CH 3) 2, -CH 2 N(CH 3) 2, -CH 2 N(CH 3)CH 2 CH 3, -CH 2 N(CH 2 CH 3) 2, -CH 2 N(CH 3)CH(CH 3) 2, -CH 2 -azetidinyl, -CH 2 -pyrrolidinyl, and -CH 2 -piperidinyl; R 6 is selected from the amino acid side chains of Gly, Ala, Val, Ser, Phe, Lys, Thr, Met, Tyr, His, Asp, Glu, Asn, Gin, Cys, Sec, Ile, Leu, Arg, Orn, Cit, Trp, 1-Me-Trp and Nva; and R 7 and R 8 are each independently selected from hydrogen and methyl, or, when R 7 is H, R 6 and R 8 together with the nitrogen atom carrying R 8 form pyrrolidine ring (proline side chain); or a pharmaceutically acceptable salt thereof. R 1 is selected from the group consisting of H, straight-chain or branched (C 1 -C 6)alkyl, HC -, and (C 1 -C 6)alkyl-C -; R 2 and R 3 are each independently selected from hydrogen, straight-chain or branched (C 1 -C 6)alkyl or (C 1 -C 6)alkyl-C -, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form a 4-, 5-, 6- or 7- membered ring that is fully saturated, or partially saturated, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form a diester of the boronic acid and polyalcohols selected from: pinanediol, mannitol, glycerol, xylitol, sorbitol, or erythritol, or R 2 and R 3 taken together with the boron atom and oxygen atoms to which they are bound form an anhydride or mixed ester-anhydride of the boronic acid and hydroxy acids or di-carboxylic acids selected from: iminodiacetic acid or N- methyliminodiacetic acid or oxalic acid or tartaric acid or citric acid or malic acid or malonic acid or mandelic acid or glycolic acid or lactic acid or 3-hydroxypropionic acid; R 4 is selected from the group consisting of H, straight-chain and branched (C 1 -C 6)alkyl; R 5 is selected from the group consisting of H, F, methyl, ethyl, propyl, isopropyl, -CH 2 NH 2, -CH 2 NHCH 3, -CH 2 NHCH 2 CH 3, -CH 2 NHCH(CH 3) 2, -CH 2 N(CH 3) 2, -CH 2 N(CH 3)CH 2 CH 3, -CH 2 N(CH 2 CH 3) 2, -CH 2 N(CH 3)CH(CH 3) 2, -CH 2 -azetidinyl, -CH 2 -pyrrolidinyl, and -CH 2 -piperidinyl; R 6 is selected from the amino acid side chains of Gly, Ala, Val, Ser, Phe, Lys, Thr, Met, Tyr, His, Asp, Glu, Asn, Gin, Cys, Sec, Ile, Leu, Arg, Orn, Cit, Trp, 1-Me-Trp and Nva; and R 7 and R 8 are each independently selected from hydrogen and methyl, or, when R 7 is H, R 6 and R 8 together with the nitrogen atom carrying R 8 form pyrrolidine ring (proline side chain);