A heart valve prosthesis configured to be anchored to an interventricular septum, the heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313); the valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520); the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515); one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal portion of the valve stitching section (112, 212, 312, 412, 512); and another end of the fixing and supporting section (114, 214, 314, 514) is configured to be connected solely to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and limit axial movement of the heart valve prosthesis (100, 200, 300, 400, 500); wherein the fixing and supporting section (114, 214, 314, 514) is provided with a curved section, which is configured to enable a proximal portion of the fixing and supporting section (114, 214, 314, 514) to cling to the interventricular septum (183, 383) of the patient; characterized in that: the fixing and supporting section (114, 214, 314, 514) comprises a plurality of rods or wires; one end of each of the plurality of rods or wires is connected to the valve stitching section (112, 212, 312, 412, 512); and other ends of the plurality of rods or wires are mutually connected and are configured to be connected to the interventricular septum (183, 383) of the patient by the fixing member (115, 215, 315, 415, 515). the heart valve prosthesis (100, 200, 300, 400, 500) comprises a valve supporting frame (110, 210, 310) and a fixing device (113, 213, 313); the valve supporting frame (110, 210, 310) comprises a valve stitching section (112, 212, 312, 412, 512) and an artificial valve (120, 520); the artificial valve (120, 520) is fixedly connected to the valve stitching section (112, 212, 312, 412, 512); the fixing device (113, 213, 313) comprises a fixing and supporting section (114, 214, 314, 514) and a fixing member (115, 215, 315, 415, 515); one end of the fixing and supporting section (114, 214, 314, 514) is connected to a proximal portion of the valve stitching section (112, 212, 312, 412, 512); and another end of the fixing and supporting section (114, 214, 314, 514) is configured to be connected solely to the interventricular septum (183, 383) of a patient by the fixing member (115, 215, 315, 415, 515), to support the heart valve prosthesis (100, 200, 300, 400, 500) and limit axial movement of the heart valve prosthesis (100, 200, 300, 400, 500); wherein the fixing and supporting section (114, 214, 314, 514) is provided with a curved section, which is configured to enable a proximal portion of the fixing and supporting section (114, 214, 314, 514) to cling to the interventricular septum (183, 383) of the patient; characterized in that: the fixing and supporting section (114, 214, 314, 514) comprises a plurality of rods or wires; one end of each of the plurality of rods or wires is connected to the valve stitching section (112, 212, 312, 412, 512); and other ends of the plurality of rods or wires are mutually connected and are configured to be connected to the interventricular septum (183, 383) of the patient by the fixing member (115, 215, 315, 415, 515).