Compounds of the formula I in which p EMBED ISISServer D denotes pyrrolidinyl, imidazolinyl, bicyclo[2.2.1]hept-5-yl, morpholinyl or N, Z denotes imidazopyrimidinyl, triazolopyrimidinyl or pyrrolopyrimidinyl, where Z is bonded to a nitrogen of the radical D, Y denotes (CH 2) n or is absent, X denotes O(CH 2) r, NH, NA, OC(=O), NHSO 2 or is absent, R 1 denotes H, A or COA, R denotes Het, Het denotes a bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N and/or O and/or S atoms which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH 2) m OR 6, (CH 2) m N(R 6) 2, (CH 2) m CN, (CH 2) m COOR 6, CONH(CH 2) m COOH, CONH(CH 2) m Het 2, CO(CH 2) m N(R 6) 2, CO(CH 2) m NH(CH 2) r COOA, (CH 2) r CONH(CH 2) m Ar 1, COCH[(CH 2) m CONH 2]NH 2, COCH[(CH 2) m CONH 2]NHCOOA, COCH[(CH 2) m Het 2]NHCOOA, COCH(NHCOA)CH 2 CONH 2, (CH 2) m NHCOOA, COCH[(CH 2) m CN]NHCOOA, COO(CH 2) m CN, COO(CH 2) m N(R 6) 2, CO(CH 2) m CON(R 6) 2, COR 6, COHet 2, O(CH 2) m Ar 1 and/or =O (carbonyl oxygen), Het 2 denotes imidazolyl, indolyl, isoxazolyl, pyridazinyl, pyrazolyl, benzimidazolyl, pyridyl, dibenzofuranyl, carbazolyl, benzofuranyl, isoindolyl, quinazolinyl, quinoxalinyl, pyrimidinyl, indazolyl, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, triazolyl, tetrazolyl, thiadiazole, benzothiazolyl, imidazo[1,2- a]-pyridinyl or 1,3-benzodioxolyl, R 6 denotes H or alkyl having 1-6 C atoms, Ar 1 denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal and/or SO 2 NH 2, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F, Cl, Br and/or OH, or cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, m denotes 0, 1, 2, 3, 4, 5 or 6, n denotes 1 or 2, q denotes 0, 1, 2, 3 or 4, r denotes 0, 1 or 2, and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. p EMBED ISISServer D denotes pyrrolidinyl, imidazolinyl, bicyclo[2.2.1]hept-5-yl, morpholinyl or N, Z denotes imidazopyrimidinyl, triazolopyrimidinyl or pyrrolopyrimidinyl, where Z is bonded to a nitrogen of the radical D, Y denotes (CH 2) n or is absent, X denotes O(CH 2) r, NH, NA, OC(=O), NHSO 2 or is absent, R 1 denotes H, A or COA, R denotes Het, Het denotes a bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N and/or O and/or S atoms which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH 2) m OR 6, (CH 2) m N(R 6) 2, (CH 2) m CN, (CH 2) m COOR 6, CONH(CH 2) m COOH, CONH(CH 2) m Het 2, CO(CH 2) m N(R 6) 2, CO(CH 2) m NH(CH 2) r COOA, (CH 2) r CONH(CH 2) m Ar 1, COCH[(CH 2) m CONH 2]NH 2, COCH[(CH 2) m CONH 2]NHCOOA, COCH[(CH 2) m Het 2]NHCOOA, COCH(NHCOA)CH 2 CONH 2, (CH 2) m NHCOOA, COCH[(CH 2) m CN]NHCOOA, COO(CH 2) m CN, COO(CH 2) m N(R 6) 2, CO(CH 2) m CON(R 6) 2, COR 6, COHet 2, O(CH 2) m Ar 1 and/or =O (carbonyl oxygen), Het 2 denotes imidazolyl, indolyl, isoxazolyl, pyridazinyl, pyrazolyl, benzimidazolyl, pyridyl, dibenzofuranyl, carbazolyl, benzofuranyl, isoindolyl, quinazolinyl, quinoxalinyl, pyrimidinyl, indazolyl, furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, triazolyl, tetrazolyl, thiadiazole, benzothiazolyl, imidazo[1,2- a]-pyridinyl or 1,3-benzodioxolyl, R 6 denotes H or alkyl having 1-6 C atoms, Ar 1 denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal and/or SO 2 NH 2, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F, Cl, Br and/or OH, or cyclic alkyl having 3-7 C atoms, Hal denotes F, Cl, Br or I, m denotes 0, 1, 2, 3, 4, 5 or 6, n denotes 1 or 2, q denotes 0, 1, 2, 3 or 4, r denotes 0, 1 or 2,