A compound of general formula or a pharmaceutically acceptable salt or stereoisomer thereof R-X-Y-ONO 2 wherein R is the prostaglandin residue of formula: wherein the symbol --- represents a single bond L is X is -O- or -S-, Y is a bivalent radical having the following meaning: a) - straight or branched C 1 -C 20 alkylene, being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, -ONO 2 or T, wherein T is -OC (C 1 -C 10 alkyl)-ONO 2 or -O(C 1 -C 10 alkyl)-ONO 2; - cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T 1, wherein T 1 is straight or branched C 1 -C 10 alkyl; b) c) wherein n is an integer from 0 to 20, and n 1 is an integer from 1 to 20; d) wherein X 1 = -OCO- or -COO- and R 2 is H or CH 3; Z is - n 1 - or the bivalent radical defined above under b) n 1 is as defined above and n 2 is an integer from 0 to 2; e) wherein: Y 1 is -CH 2 -CH 2 -(CH 2) n 2 -; or -CH=CH-(CH 2) n 2 -; Z is - n 1 - or the bivalent radical defined above under b) n 1, n 2, R 2 and X 1 are as defined above; f) wherein: n 1 and R 2 are as defined above, R 3 is H or -COCH 3; with the proviso that when Y is selected from the bivalent radicals mentioned under b)-f), the -ONO 2 group is bound to -(CH 2) n 1; g) wherein X 2 is -O- or -S-, n 3 is an integer from 1 to 6 and R 2 is as defined above; h) wherein: n 4 is an integer from 0 to 10; n 5 is an integer from 1 to 10; R 4, R 5, R 6, R 7 are the same or different, and are H or straight or branched C 1 -C 4 alkyl; wherein the -ONO 2 group is linked to wherein n 5 is as defined above; Y 2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, and is selected from a) - straight or branched C 1 -C 20 alkylene, being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, -ONO 2 or T, wherein T is -OC (C 1 -C 10 alkyl)-ONO 2 or -O(C 1 -C 10 alkyl)-ONO 2; - cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T 1, wherein T 1 is straight or branched C 1 -C 10 alkyl; - straight or branched C 1 -C 20 alkylene, being optionally substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, -ONO 2 or T, wherein T is -OC (C 1 -C 10 alkyl)-ONO 2 or -O(C 1 -C 10 alkyl)-ONO 2; - cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T 1, wherein T 1 is straight or branched C 1 -C 10 alkyl; b) c) wherein n is an integer from 0 to 20, and n 1 is an integer from 1 to 20; d) wherein X 1 = -OCO- or -COO- and R 2 is H or CH 3; Z is - n 1 - or the bivalent radical defined above under b) n 1 is as defined above and n 2 is an integer from 0 to 2; e) wherein: Y 1 is -CH 2 -CH 2 -(CH 2) n 2 -; or -CH=CH-(CH 2) n 2 -; Z is - n 1 - or the bivalent radical defined above under b) n 1, n 2, R 2 and X 1 are as defined above; Y 1 is -CH 2 -CH 2 -(CH 2) n 2 -; or -CH=CH-(CH 2) n 2 -; Z is - n 1 - or the bivalent radical defined above under b) n 1, n 2, R 2 and X 1 are as defined above; f) n 1 and R 2 are as defined above, R 3 is H or -COCH 3; with the proviso that when Y is selected from the bivalent radicals mentioned under b)-f), the -ONO 2 group is bound to -(CH 2) n 1; g) wherein X 2 is -O- or -S-, n 3 is an integer from 1 to 6 and R 2 is as defined above; h) wherein: n 4 is an integer from 0 to 10; n 5 is an integer from 1 to 10; R 4, R 5, R 6, R 7 are the same or different, and are H or straight or branched C 1 -C 4 alkyl; wherein the -ONO 2 group is linked to wherein n 5 is as defined above; Y 2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, and is selected from n 4 is an integer from 0 to 10; n 5 is an integer from 1 to 10; R 4, R 5, R 6, R 7 are the same or different, and are H or straight or branched C 1 -C 4 alkyl; wherein the -ONO 2 group is linked to wherein n 5 is as defined above; Y 2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, and is selected from