A reloadable clipping device, comprising: a clip assembly (102, 102') including a pair of clip arms, each of the clip arms extending from a proximal end to a distal end, the proximal end of each of the clip arms connected to one another via a yoke received within a channel of a capsule (116, 116') to move the clip arms between a tissue receiving configuration, in which distal ends of the clip arms are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another; an applicator (104, 104') having a distal portion insertable through an opening of a cartridge housing the clip assembly to be coupled to the clip assembly (102, 102'), the applicator (104, 104') including a catheter (144, 144') and a control member (106, 106'), the catheter (144, 144') extending from a proximal end to a distal end (152, 152') and including a lumen extending therethrough, the distal end (152, 152') of the catheter (144, 144') configured to be coupled to a proximal end (138, 138') of the capsule (116, 116'), the control member (106, 106') extending through the lumen of the catheter (144, 144') and including a plurality of nodes extending along a distal portion thereof, each node having a cross-sectional area larger than a cross-sectional area of a remaining portion of the control member (106, 106') and configured to be coupled to the proximal end of the clip arms, a distal-most one of the nodes being severable from a next immediately proximal one of the nodes, when a force exerted thereon exceeds a predetermined threshold value, to release the clip assembly (102, 102') from the applicator (104, 104'). a clip assembly (102, 102') including a pair of clip arms, each of the clip arms extending from a proximal end to a distal end, the proximal end of each of the clip arms connected to one another via a yoke received within a channel of a capsule (116, 116') to move the clip arms between a tissue receiving configuration, in which distal ends of the clip arms are separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another; an applicator (104, 104') having a distal portion insertable through an opening of a cartridge housing the clip assembly to be coupled to the clip assembly (102, 102'), the applicator (104, 104') including a catheter (144, 144') and a control member (106, 106'), the catheter (144, 144') extending from a proximal end to a distal end (152, 152') and including a lumen extending therethrough, the distal end (152, 152') of the catheter (144, 144') configured to be coupled to a proximal end (138, 138') of the capsule (116, 116'), the control member (106, 106') extending through the lumen of the catheter (144, 144') and including a plurality of nodes extending along a distal portion thereof, each node having a cross-sectional area larger than a cross-sectional area of a remaining portion of the control member (106, 106') and configured to be coupled to the proximal end of the clip arms, a distal-most one of the nodes being severable from a next immediately proximal one of the nodes, when a force exerted thereon exceeds a predetermined threshold value, to release the clip assembly (102, 102') from the applicator (104, 104').