A sealant applicator, comprising: two chambers (112A, 112B) separate from one another, each chamber comprising at least one output port (112A-1, 112B-1) on a distal end thereof; and a quarter turn connector (300, 700) disposed on a distal end of the sealant applicator adjacent to the at least one output port of each chamber, the quarter turn connector shaped to releasably interlock with a corresponding quarter turn connector of an injection needle assembly comprising a plurality of input ports (132A-1, 132B-1) or with a corresponding quarter turn connector of a dual chamber mixing syringe comprising a plurality of mixing ports (122A-1, 122B-1), wherein, when the injection needle assembly or the dual chamber mixing syringe is coupled to the sealant applicator via the quarter turn connector, the plurality of input ports or the plurality of mixing ports are aligned and sealed with the at least one output port of each chamber of the sealant applicator; wherein the quarter turn connector comprises: a circular protrusion extending distally from the distal end of the sealant applicator, the circular protrusion comprising the at least one output port of each of the two chambers; a semi-circular channel disposed within the distal end of the sealant applicator along a periphery of the circular protrusion; and a pair of bayonet coupling members (306A, 306B) disposed radially outward of the circular protrusion and the semi-circular channel. two chambers (112A, 112B) separate from one another, each chamber comprising at least one output port (112A-1, 112B-1) on a distal end thereof; and a quarter turn connector (300, 700) disposed on a distal end of the sealant applicator adjacent to the at least one output port of each chamber, the quarter turn connector shaped to releasably interlock with a corresponding quarter turn connector of an injection needle assembly comprising a plurality of input ports (132A-1, 132B-1) or with a corresponding quarter turn connector of a dual chamber mixing syringe comprising a plurality of mixing ports (122A-1, 122B-1), wherein, when the injection needle assembly or the dual chamber mixing syringe is coupled to the sealant applicator via the quarter turn connector, the plurality of input ports or the plurality of mixing ports are aligned and sealed with the at least one output port of each chamber of the sealant applicator; wherein the quarter turn connector comprises: a circular protrusion extending distally from the distal end of the sealant applicator, the circular protrusion comprising the at least one output port of each of the two chambers; a semi-circular channel disposed within the distal end of the sealant applicator along a periphery of the circular protrusion; and a pair of bayonet coupling members (306A, 306B) disposed radially outward of the circular protrusion and the semi-circular channel. a circular protrusion extending distally from the distal end of the sealant applicator, the circular protrusion comprising the at least one output port of each of the two chambers; a semi-circular channel disposed within the distal end of the sealant applicator along a periphery of the circular protrusion; and a pair of bayonet coupling members (306A, 306B) disposed radially outward of the circular protrusion and the semi-circular channel.