Targeting system comprising a targeting device for positioning of a medical sub device with respect to a medical device, an imaging system, and an evaluation unit, wherein the targeting device comprises: a targeting device coupling section for uniquely coupling a medical device having a medical device coupling section and a medical sub device receptacle, a reference body, and a targeting unit, wherein the reference body is reproducibly positioned with respect to the targeting device coupling section and reproducibly positioned with respect to the targeting unit; wherein the targeting unit has a targeting direction and is adjustable with respect to the targeting device so that the targeting direction points toward a medical sub device receptacle of a medical device to be coupled to the targeting device coupling section, wherein the imaging system is positionable with respect to the targeting device such that the imaging system is capable of imaging a single two-dimensional view of the reference body and a medical sub device receptacle of a medical device to be coupled, wherein the evaluation unit is adapted to generate data of the single two-dimensional view and to determine from the data a lateral distance (d) between the targeting direction and a receiving direction of a medical sub device receptacle of a medical device to be coupled, wherein the imaging system comprises a radiating source and a sensor, the sensor being sensitive with respect to the radiating source, wherein the radiating source is substantially punctual, characterized in that the evaluation unit is adapted to determine the lateral distance (d) of the targeting direction and the receiving direction by evaluating a size of the projected medical sub device receptacle with respect to a size of the reference body so as to distinguish two translational degrees of freedom. a targeting device for positioning of a medical sub device with respect to a medical device, an imaging system, and an evaluation unit, a targeting device coupling section for uniquely coupling a medical device having a medical device coupling section and a medical sub device receptacle, a reference body, and a targeting unit, wherein the reference body is reproducibly positioned with respect to the targeting device coupling section and reproducibly positioned with respect to the targeting unit; wherein the targeting unit has a targeting direction and is adjustable with respect to the targeting device so that the targeting direction points toward a medical sub device receptacle of a medical device to be coupled to the targeting device coupling section, wherein the imaging system is positionable with respect to the targeting device such that the imaging system is capable of imaging a single two-dimensional view of the reference body and a medical sub device receptacle of a medical device to be coupled, wherein the evaluation unit is adapted to generate data of the single two-dimensional view and to determine from the data a lateral distance (d) between the targeting direction and a receiving direction of a medical sub device receptacle of a medical device to be coupled, wherein the imaging system comprises a radiating source and a sensor, the sensor being sensitive with respect to the radiating source, wherein the radiating source is substantially punctual, characterized in that the evaluation unit is adapted to determine the lateral distance (d) of the targeting direction and the receiving direction by evaluating a size of the projected medical sub device receptacle with respect to a size of the reference body so as to distinguish two translational degrees of freedom.