An infusion/aspiration system, comprising: an infusion/aspiration catheter (14", 14"'), comprising: an elongate catheter body having a proximal end, a distal end, at least one infusion lumen and an aspiration lumen extending between the proximal end and the distal end, the aspiration lumen terminating in a distal fluid port at the distal end of the elongate catheter body; a plurality of arms respectively having proximal ends affixed together at the distal end of the elongate catheter body, the distal fluid port of the elongate catheter body being between the proximal ends of the plurality of arms, the arms having lumens in fluid communication with the at least one infusion lumen, each of the arms having at least one fluid port in fluid communication with the lumen of the respective arm; at least one infusion connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one infusion lumen; an aspiration connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one aspiration lumen; and a distal hub at which distal ends of the arms are affixed together, the plurality of arms being pre-shaped to expand outward in the absence of an external force; a vacuum source or drain connected to the aspiration connector; characterized in that the infusion/aspiration system further comprises: a source of recombinant tissue plasminogen activator (rt-PA) connected to the at least one infusion connector. an infusion/aspiration catheter (14", 14"'), comprising: an elongate catheter body having a proximal end, a distal end, at least one infusion lumen and an aspiration lumen extending between the proximal end and the distal end, the aspiration lumen terminating in a distal fluid port at the distal end of the elongate catheter body; a plurality of arms respectively having proximal ends affixed together at the distal end of the elongate catheter body, the distal fluid port of the elongate catheter body being between the proximal ends of the plurality of arms, the arms having lumens in fluid communication with the at least one infusion lumen, each of the arms having at least one fluid port in fluid communication with the lumen of the respective arm; at least one infusion connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one infusion lumen; an aspiration connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one aspiration lumen; and a distal hub at which distal ends of the arms are affixed together, the plurality of arms being pre-shaped to expand outward in the absence of an external force; an elongate catheter body having a proximal end, a distal end, at least one infusion lumen and an aspiration lumen extending between the proximal end and the distal end, the aspiration lumen terminating in a distal fluid port at the distal end of the elongate catheter body; a plurality of arms respectively having proximal ends affixed together at the distal end of the elongate catheter body, the distal fluid port of the elongate catheter body being between the proximal ends of the plurality of arms, the arms having lumens in fluid communication with the at least one infusion lumen, each of the arms having at least one fluid port in fluid communication with the lumen of the respective arm; at least one infusion connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one infusion lumen; an aspiration connector affixed to the proximal end of the elongate catheter body in fluid communication with the at least one aspiration lumen; and a distal hub at which distal ends of the arms are affixed together, the plurality of arms being pre-shaped to expand outward in the absence of an external force; a vacuum source or drain connected to the aspiration connector; characterized in that the infusion/aspiration system further comprises: a source of recombinant tissue plasminogen activator (rt-PA) connected to the at least one infusion connector.