A laparoscopic clip applier comprising: a jaw assembly comprising a pair of opposed jaws configured to receive and clamp a surgical clip; a shaft assembly extending from a proximal end to a distal end, the jaw assembly positioned at the distal end of the shaft assembly, and the shaft assembly comprising a first slider and a second slider at the proximal end, the first and second slider being configured to actuate clip feed and closure mechanisms within the shaft assembly; and a handle assembly comprising: a stationary handle; a movable handle pivotably coupled to the stationary handle; a first actuation mechanism coupled to the movable handle and to the first slider; and a second actuation mechanism, the second actuation mechanism comprising: a gear rotatably driven by pivotal movement of the movable handle, the gear having a first plurality of teeth and a second plurality of teeth; and a longitudinal slider having a first rack engageable with the first plurality of teeth; the longitudinal slider being engageable with the second slider of the shaft assembly; the first plurality of teeth defining a first advancement profile of the longitudinal slider defined by the longitudinal slider advancing a first longitudinal distance per degree of rotation of the movable handle; characterized in that the longitudinal slider comprises a second rack sequentially engageable with the second plurality of teeth; wherein once the longitudinal slider has been advanced a first distance, the second plurality of drive teeth engage the second drive rack on the longitudinal slider to define a second advancement profile of the longitudinal slider. a jaw assembly comprising a pair of opposed jaws configured to receive and clamp a surgical clip; a shaft assembly extending from a proximal end to a distal end, the jaw assembly positioned at the distal end of the shaft assembly, and the shaft assembly comprising a first slider and a second slider at the proximal end, the first and second slider being configured to actuate clip feed and closure mechanisms within the shaft assembly; and a handle assembly comprising: a stationary handle; a movable handle pivotably coupled to the stationary handle; a first actuation mechanism coupled to the movable handle and to the first slider; and a second actuation mechanism, the second actuation mechanism comprising: a gear rotatably driven by pivotal movement of the movable handle, the gear having a first plurality of teeth and a second plurality of teeth; and a longitudinal slider having a first rack engageable with the first plurality of teeth; the longitudinal slider being engageable with the second slider of the shaft assembly; the first plurality of teeth defining a first advancement profile of the longitudinal slider defined by the longitudinal slider advancing a first longitudinal distance per degree of rotation of the movable handle; a stationary handle; a movable handle pivotably coupled to the stationary handle; a first actuation mechanism coupled to the movable handle and to the first slider; and a second actuation mechanism, the second actuation mechanism comprising: a gear rotatably driven by pivotal movement of the movable handle, the gear having a first plurality of teeth and a second plurality of teeth; and a longitudinal slider having a first rack engageable with the first plurality of teeth; the longitudinal slider being engageable with the second slider of the shaft assembly; a gear rotatably driven by pivotal movement of the movable handle, the gear having a first plurality of teeth and a second plurality of teeth; and a longitudinal slider having a first rack engageable with the first plurality of teeth; the longitudinal slider being engageable with the second slider of the shaft assembly; the first plurality of teeth defining a first advancement profile of the longitudinal slider defined by the longitudinal slider advancing a first longitudinal distance per degree of rotation of the movable handle; characterized in that the longitudinal slider comprises a second rack sequentially engageable with the second plurality of teeth; wherein once the longitudinal slider has been advanced a first distance, the second plurality of drive teeth engage the second drive rack on the longitudinal slider to define a second advancement profile of the longitudinal slider.