Compound of formula and pharmaceutically acceptable salts thereof: wherein R1, R2 represents independently from each other a group chosen amongst: Hydrogen; or NHC NH-C1-6-alkyl; or NHSO 2 -C1-6-alkyl; or NHC NH-heteroaryl optionally substituted with one or more R1 a; or heteroaryl optionally substituted with one or more group chosen amongst amino; C1-6-alkyl; C O-C1-6-alkyl; nitrile; heteroaryl optionally substituted with one or more R1 a; NH-C1-6-alkyl; NH-C1-6-heterocycloalkyl; NH-C3-9-cycloalkyl; NH-heteroaryl optionally substituted with one or more R1 a; or NH-heteroaryl optionally substituted with one or more group chosen amongst; C1-6-alkyl; C1-6-hydroxyalkyl; C3-9-hydroxyheterocycloalkyl; heteroaryl optionally substituted with one or more R1 a; or NHC -C1-6-alkyl; or NHC -heteroaryl optionally substituted with one or more R1 a R1 a represents a group chosen amongst: Halogen; nitrile; C1-6-alkyl; C1-6-haloalkyl; C1-6-alkoxy; C1-6-haloalkoxy; C O-C1-6-alkyl; C OH; R3 represents a group chosen amongst: C1-6-alkyl optionally substituted with one or more group chosen amongst R3 a; C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3 a; C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-cycloalkyl optionally substituted with one or more R3 a; R3 a represents a group chosen amongst hydrogen Halogen, C1-2-alkyl; hydroxy; C1-2-alkoxy R4 represents a group chosen amongst: C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4 a group; R4 a represents a group chosen amongst hydroxy; Halogen; C1-2-alkyl. Hydrogen; or NHC NH-C1-6-alkyl; or NHSO 2 -C1-6-alkyl; or NHC NH-heteroaryl optionally substituted with one or more R1 a; or heteroaryl optionally substituted with one or more group chosen amongst amino; C1-6-alkyl; C O-C1-6-alkyl; nitrile; heteroaryl optionally substituted with one or more R1 a; NH-C1-6-alkyl; NH-C1-6-heterocycloalkyl; NH-C3-9-cycloalkyl; NH-heteroaryl optionally substituted with one or more R1 a; or NH-heteroaryl optionally substituted with one or more group chosen amongst; C1-6-alkyl; C1-6-hydroxyalkyl; C3-9-hydroxyheterocycloalkyl; heteroaryl optionally substituted with one or more R1 a; or NHC -C1-6-alkyl; or NHC -heteroaryl optionally substituted with one or more R1 a R1 a represents a group chosen amongst: Halogen; nitrile; C1-6-alkyl; C1-6-haloalkyl; C1-6-alkoxy; C1-6-haloalkoxy; C O-C1-6-alkyl; C OH; R3 represents a group chosen amongst: C1-6-alkyl optionally substituted with one or more group chosen amongst R3 a; C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3 a; C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-cycloalkyl optionally substituted with one or more R3 a; R3 a represents a group chosen amongst hydrogen Halogen, C1-2-alkyl; hydroxy; C1-2-alkoxy C1-6-alkyl optionally substituted with one or more group chosen amongst R3 a; C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3 a; C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-heterocycloalkyl optionally substituted with one or more R3 a; C3-6-cycloalkyl optionally substituted with one or more R3 a; R3 a represents a group chosen amongst hydrogen Halogen, C1-2-alkyl; hydroxy; C1-2-alkoxy R4 represents a group chosen amongst: C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4 a group; R4 a represents a group chosen amongst hydroxy; Halogen; C1-2-alkyl. C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4 a group; or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4 a group; R4 a represents a group chosen amongst hydroxy; Halogen; C1-2-alkyl.