An air filter cartridge comprising: (a) a filter media pack comprising a stacked construction of individual strips (200, 202) of media each comprising a fluted sheet secured to facing sheet to define inlet and outlet flow channels (11, 15) extending between first and second, opposite, flow surfaces; (b) a molded side panel arrangement comprising at least first and second, opposite, molded panels molded directly to, and in sealing coverage over, a first set of two opposite sides of the media pack defined by lead ends and tail ends of the strips (200, 202) of media; and, characterized by (c) an axial pinch housing seal arrangement; (d) the housing seal arrangement (i) being molded onto the filter cartridge; (ii) being provided spaced from the first surface toward the second surface; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough, facing in the same direction as the first surface, provided along the media pack and surrounding said pack; (v) being engagable by the housing, with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge, when installed; (e) wherein by the term axial it is meant that forces are generally directed in the same direction as extension between flow faces (305, 306). (a) a filter media pack comprising a stacked construction of individual strips (200, 202) of media each comprising a fluted sheet secured to facing sheet to define inlet and outlet flow channels (11, 15) extending between first and second, opposite, flow surfaces; (b) a molded side panel arrangement comprising at least first and second, opposite, molded panels molded directly to, and in sealing coverage over, a first set of two opposite sides of the media pack defined by lead ends and tail ends of the strips (200, 202) of media; and, characterized by (c) an axial pinch housing seal arrangement; (d) the housing seal arrangement (i) being molded onto the filter cartridge; (ii) being provided spaced from the first surface toward the second surface; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough, facing in the same direction as the first surface, provided along the media pack and surrounding said pack; (v) being engagable by the housing, with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge, when installed; (i) being molded onto the filter cartridge; (ii) being provided spaced from the first surface toward the second surface; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough, facing in the same direction as the first surface, provided along the media pack and surrounding said pack; (v) being engagable by the housing, with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge, when installed; (e) wherein by the term axial it is meant that forces are generally directed in the same direction as extension between flow faces (305, 306).