mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula: wherein R 1 is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C 1-6 alkyl, C 3-6 cycloalkyl, halo, -CN or -NHSO 2 R 5, or pyridinyl optionally substituted by one or two substituents independently selected from C 1 - 6 alkyl, -OR 6, halo and -NHSO 2 R 7; R 2 and R 3, together with the nitrogen atom to which they are attached, are linked to form a 6- or 7-membered heterocyclyl wherein the 6- or 7-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl; R 4 is hydrogen or methyl; R 6 is hydrogen or C 1-4 alkyl; and R 5 and R 7 are each independently C 1-6 alkyl, or phenyl optionally substituted by one or two substituents independently selected from halo; or a pharmaceutically acceptable salt thereof, for use in the treatment of a disorder wherein the underlying pathology is attributable to inappropriate PI3-kinase activity resulting from overexpression or mutation of the protein kinase leading to inappropriate or uncontrolled activation. R 1 is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C 1-6 alkyl, C 3-6 cycloalkyl, halo, -CN or -NHSO 2 R 5, or pyridinyl optionally substituted by one or two substituents independently selected from C 1 - 6 alkyl, -OR 6, halo and -NHSO 2 R 7; R 2 and R 3, together with the nitrogen atom to which they are attached, are linked to form a 6- or 7-membered heterocyclyl wherein the 6- or 7-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl; R 4 is hydrogen or methyl; R 6 is hydrogen or C 1-4 alkyl; and R 5 and R 7 are each independently C 1-6 alkyl, or phenyl optionally substituted by one or two substituents independently selected from halo; or a pharmaceutically acceptable salt thereof, for use in the treatment of a disorder wherein the underlying pathology is attributable to inappropriate PI3-kinase activity resulting from overexpression or mutation of the protein kinase leading to inappropriate or uncontrolled activation.
A nitrated peptide selected from the group consisting of: a peptide consisting of the amino acid sequence shown in SEQ ID NO:1; a peptide comprising the amino acid sequence shown in SEQ ID NO:2; and a peptide comprising the amino acid sequence shown in SEQ ID NO:4. a peptide consisting of the amino acid sequence shown in SEQ ID NO:1; a peptide comprising the amino acid sequence shown in SEQ ID NO:2; and a peptide comprising the amino acid sequence shown in SEQ ID NO:4.
A process for extending the operating temperature range of gigabit plastic optical fiber, the process comprising: (a) placing a length of plastic optical fiber inside a thermal chamber, which plastic optical fiber has a core with dopant distributed in a polymer matrix such that the plastic optical fiber has a high-data-rate capability at a first temperature but not at a second temperature which is higher than the first temperature; (b) decreasing a temperature inside the thermal chamber until a third temperature lower than the first temperature is reached; (c) maintaining the third temperature inside the thermal chamber for a first period of time sufficient to cause the plastic optical fiber to develop the high-data-rate capability at the second temperature, wherein the polymer matrix of the length of gigabit plastic optical fiber is stabilized using thermal cooling so that diffusion of the dopant is blocked in a high-temperature environment; (d) increasing the temperature inside the thermal chamber until a fourth temperature lower than the first temperature and higher than the third temperature is reached; (e) maintaining the fourth temperature inside the thermal chamber during a second period of time subsequent to the first period of time; and (f) removing the length of plastic optical fiber from the thermal chamber. (a) placing a length of plastic optical fiber inside a thermal chamber, which plastic optical fiber has a core with dopant distributed in a polymer matrix such that the plastic optical fiber has a high-data-rate capability at a first temperature but not at a second temperature which is higher than the first temperature; (b) decreasing a temperature inside the thermal chamber until a third temperature lower than the first temperature is reached; (c) maintaining the third temperature inside the thermal chamber for a first period of time sufficient to cause the plastic optical fiber to develop the high-data-rate capability at the second temperature, wherein the polymer matrix of the length of gigabit plastic optical fiber is stabilized using thermal cooling so that diffusion of the dopant is blocked in a high-temperature environment; (d) increasing the temperature inside the thermal chamber until a fourth temperature lower than the first temperature and higher than the third temperature is reached; (e) maintaining the fourth temperature inside the thermal chamber during a second period of time subsequent to the first period of time; and (f) removing the length of plastic optical fiber from the thermal chamber.
A method, comprising: removing a worn portion (100, 102, 120) from a component (44, 62, 64) of a rotary isobaric pressure exchanger (IPX, 30) configured to exchange pressures between a first fluid and a second fluid, wherein the component comprises at least one of a rotor or an end cover (62, 64) including a removable end portion that is detachably connected to the rotor or the end cover (62, 64), the removable end portion having the worn portion (100, 102, 120), and wherein the worn portion (100, 102, 120) comprises at least one surface on the rotor or the end cover (62, 64), the at least one surface being a surface of an interface region between the rotor and the end cover (62, 64); and repairing the component (44, 62, 64) after the worn portion (100, 102, 120) is removed from the component (44, 62, 64) by coupling a replacement portion (134, 150) to the component (44, 62, 64), wherein the replacement portion (134, 150) has a similar structure to the removable end portion before the removable end portion being worn. removing a worn portion (100, 102, 120) from a component (44, 62, 64) of a rotary isobaric pressure exchanger (IPX, 30) configured to exchange pressures between a first fluid and a second fluid, wherein the component comprises at least one of a rotor or an end cover (62, 64) including a removable end portion that is detachably connected to the rotor or the end cover (62, 64), the removable end portion having the worn portion (100, 102, 120), and wherein the worn portion (100, 102, 120) comprises at least one surface on the rotor or the end cover (62, 64), the at least one surface being a surface of an interface region between the rotor and the end cover (62, 64); and repairing the component (44, 62, 64) after the worn portion (100, 102, 120) is removed from the component (44, 62, 64) by coupling a replacement portion (134, 150) to the component (44, 62, 64), wherein the replacement portion (134, 150) has a similar structure to the removable end portion before the removable end portion being worn.
An adhesive tape for sealing a joint in an insulation system, comprising a first layer which forms a vapour barrier and is adapted to form an outside of the adhesive tape, a hygroscopic material which is supported by the first layer and, when applying the adhesive tape for sealing a joint in an insulation system, is adapted to be in contact with the joint, and at least one adhesive connecting portion which is arranged on an inside of the adhesive tape and which, when applying the adhesive tape, is adapted to adhere to the insulation system on at least one side of the joint.
A combustion chamber of a turbine engine, comprising at least one wall defining the combustion chamber and comprising an aperture for enabling a through-part to pass therethrough, said through-part comprising, in the portion thereof located within the combustion chamber, at least one opening able to create an air film for cooling the area downstream of the through-part, characterized in that the inner surface of said at least one wall includes two tongues (31a, 31b) extending substantially parallel to each other, able to generate an air film for cooling said at least one wall, the through-part being located between both tongues (31a, 31b).
A portable electronic device for use in a vehicle, comprising: (a) a user interface means through which user input is received, including input to operate the portable electronic device to provide a plurality of functions; (b) at least one portion of a speed detector wherein the speed detector is configured to detect a speed of the portable electronic device, wherein the speed detector is configured to generate and communicate a speed signal indicative of the detected speed; (c) a safety circuit in communication with the speed detector, wherein the safety circuit is configured to receive the speed signal communicated from the speed detector, wherein the safety circuit includes a threshold logic, wherein the threshold logic is configured to compare the speed indicated by the speed signal to a threshold, wherein the safety circuit is further configured to disable at least one of the functions of the portable electronic device in response to the detected speed indicated by the speed signal exceeding the threshold in accordance with the threshold logic; and (d) an override logic for selectively overriding at least a part of the disablement provided by the safety circuit under one or more predetermined override conditions. (a) a user interface means through which user input is received, including input to operate the portable electronic device to provide a plurality of functions; (b) at least one portion of a speed detector wherein the speed detector is configured to detect a speed of the portable electronic device, wherein the speed detector is configured to generate and communicate a speed signal indicative of the detected speed; (c) a safety circuit in communication with the speed detector, wherein the safety circuit is configured to receive the speed signal communicated from the speed detector, wherein the safety circuit includes a threshold logic, wherein the threshold logic is configured to compare the speed indicated by the speed signal to a threshold, wherein the safety circuit is further configured to disable at least one of the functions of the portable electronic device in response to the detected speed indicated by the speed signal exceeding the threshold in accordance with the threshold logic; and (d) an override logic for selectively overriding at least a part of the disablement provided by the safety circuit under one or more predetermined override conditions.
A process to measure the amount of "Y-PE-type long chain branching per 1000 total carbons" in an ethylene/α-olefin/diene interpolymer; said process comprising at least the following: a) dissolving the polymer in a solvent, to form a polymer solution; b) analyzing the polymer solution using 13C NMR, at an analysis temperature from 20°C to 200°C, and generating a 13C NMR spectrum; and wherein the polymer has a "Y-PE-type long chain branching" that has a signal for an alpha carbon (Y-PE α signal) that has a peak maximum located in the range from 34.0 ppm to 35.0 ppm; and wherein the polymer has an amount of the "Y-PE-type long chain branching" (A Y-PE) that is determined from the following Equation A: A Y-PE = Y-PE α peak area / 3 wherein the "Y-PE α, peak area" is determined by integrating the area underneath the peak of the Y-PE α signal located in the range from 34.0 ppm to 35.0 ppm; and wherein the amount of "Y-PE-type long chain branching per 1000 total carbons" is determined by integrating the area under the entire 13C NMR spectrum to obtain an area A, and then subtracting from A, the area of the "peak area due to solvent ", to obtain the "total peak area due to polymer," and wherein the "Y-PE-type long chain branching per 1000 carbons" is determined from the following Equation B: Y-PE-type long chain branching per 1000 carbons = A Y-PE / P × 1000 carbons and wherein, the location of the Y-PE α signal is determined by comparing the 13C NMR spectrum against a 13C NMR spectrum of a control polymer; and wherein the control polymer is an ethylene/1-octene copolymer that has a density from 0.910 to 0.930 g/cc and a melt index from 0.50 to 2.00 g/cc. a) dissolving the polymer in a solvent, to form a polymer solution; b) analyzing the polymer solution using 13C NMR, at an analysis temperature from 20°C to 200°C, and generating a 13C NMR spectrum; and wherein the polymer has a "Y-PE-type long chain branching" that has a signal for an alpha carbon (Y-PE α signal) that has a peak maximum located in the range from 34.0 ppm to 35.0 ppm; and wherein the polymer has an amount of the "Y-PE-type long chain branching" (A Y-PE) that is determined from the following Equation A: A Y-PE = Y-PE α peak area / 3 wherein the "Y-PE α, peak area" is determined by integrating the area underneath the peak of the Y-PE α signal located in the range from 34.0 ppm to 35.0 ppm; and wherein the amount of "Y-PE-type long chain branching per 1000 total carbons" is determined by integrating the area under the entire 13C NMR spectrum to obtain an area A, and then subtracting from A, the area of the "peak area due to solvent ", to obtain the "total peak area due to polymer," and wherein the "Y-PE-type long chain branching per 1000 carbons" is determined from the following Equation B: Y-PE-type long chain branching per 1000 carbons = A Y-PE / P × 1000 carbons and wherein, the location of the Y-PE α signal is determined by comparing the 13C NMR spectrum against a 13C NMR spectrum of a control polymer; and wherein the control polymer is an ethylene/1-octene copolymer that has a density from 0.910 to 0.930 g/cc and a melt index from 0.50 to 2.00 g/cc.
A dye of formula wherein R 1 is cyano; R 2 is chloro; R 3 is hydrogen, chloro, bromo, methoxy, trifluoromethyl, nitro or cyano; and R 4 is methyl, ethyl, n-propyl, 2-methoxyethyl, methoxycarbonylmethyl or 2-methoxycarbonylethyl. R 1 is cyano; R 2 is chloro; R 3 is hydrogen, chloro, bromo, methoxy, trifluoromethyl, nitro or cyano; and R 4 is methyl, ethyl, n-propyl, 2-methoxyethyl, methoxycarbonylmethyl or 2-methoxycarbonylethyl.
A battery pack diagnostic method, characterized in that, comprising following steps without specific order: S1: detecting a battery temperature and an ambient temperature of the battery pack; if the difference between the two temperatures is less than a preset temperature threshold, the state of temperature of the battery pack is instructed as normal, if not, the state of temperature of the battery pack is instructed as abnormal; S2: detecting a pre-load voltage of a discharge port of the battery pack before loading and a post-load voltage after loading; if the difference between the two voltages is less than a preset voltage threshold, the state of discharging circuit of the battery pack is instructed as normal, if not, the state of discharging circuit of the battery pack is instructed as abnormal; S3: detecting a charge voltage of a charge port of the battery pack and a discharge voltage of the discharge port; if the two voltages are equal, the state of charging circuit of the battery pack is instructed as normal, if not, the state of charging circuit of the battery pack is instructed as abnormal; S4: detecting whether a hot-plugging interface of the battery pack has a hot-plugging signal; if the hot-plugging interface of the battery pack has the hot-plugging signal, the state of hot-plugging interface of the battery pack is instructed as normal, if not, the state of hot-plugging interface of the battery pack is instructed as abnormal. S1: detecting a battery temperature and an ambient temperature of the battery pack; if the difference between the two temperatures is less than a preset temperature threshold, the state of temperature of the battery pack is instructed as normal, if not, the state of temperature of the battery pack is instructed as abnormal; S2: detecting a pre-load voltage of a discharge port of the battery pack before loading and a post-load voltage after loading; if the difference between the two voltages is less than a preset voltage threshold, the state of discharging circuit of the battery pack is instructed as normal, if not, the state of discharging circuit of the battery pack is instructed as abnormal; S3: detecting a charge voltage of a charge port of the battery pack and a discharge voltage of the discharge port; if the two voltages are equal, the state of charging circuit of the battery pack is instructed as normal, if not, the state of charging circuit of the battery pack is instructed as abnormal; S4: detecting whether a hot-plugging interface of the battery pack has a hot-plugging signal; if the hot-plugging interface of the battery pack has the hot-plugging signal, the state of hot-plugging interface of the battery pack is instructed as normal, if not, the state of hot-plugging interface of the battery pack is instructed as abnormal.
A method in a radio network node (12,13) for paging a user equipment in a radio communications network, which radio network node (12,13) serves a cell in the radio communications network and a location of the user equipment or cell serving the user equipment is unknown, the method comprising: - determining whether a condition is fulfilled, which condition is associated with the cell, wherein the condition is defined as when a load in the cell is below a threshold or as when available capacity in the cell is above a threshold, and wherein data to be sent to the user equipment is data of a best effort quality requirement or lower than the best effort quality requirement; and - only when the condition is fulfilled, paging the user equipment in the cell. - determining whether a condition is fulfilled, which condition is associated with the cell, wherein the condition is defined as when a load in the cell is below a threshold or as when available capacity in the cell is above a threshold, and wherein data to be sent to the user equipment is data of a best effort quality requirement or lower than the best effort quality requirement; and - only when the condition is fulfilled, paging the user equipment in the cell.
An electromagnetic pushing and knocking-type object detector, characterized in that it comprises a magnetic swinging rod; an electromagnet that is disposed on one side of the magnetic swinging rod; and an electronic module that controls the electromagnet in driving the magnetic swinging rod to swing, and amplifies, processes, and time-delay outputs the swinging signals of the magnetic swinging rod, which swinging signals are collected by the electromagnet, wherein: said magnetic swinging rod is suspended with a suspension device on one side of a main housing, and the electromagnet, which is composed of an electromagnet iron core and an electromagnet coil, is disposed inside the main housing; said electronic module comprising a power supply circuit, a pulse generating circuit, a pulse driving circuit, a signal amplification circuit, a signal processing circuit, and a signal time-delay output circuit, all of the above circuits being disposed within the main housing or being isolated from the main housing and enclosed separately. said magnetic swinging rod is suspended with a suspension device on one side of a main housing, and the electromagnet, which is composed of an electromagnet iron core and an electromagnet coil, is disposed inside the main housing; said electronic module comprising a power supply circuit, a pulse generating circuit, a pulse driving circuit, a signal amplification circuit, a signal processing circuit, and a signal time-delay output circuit, all of the above circuits being disposed within the main housing or being isolated from the main housing and enclosed separately.
A pharmaceutical composition comprising an anti-digoxin antibody composition for use in the treatment of chronic and acute disorders, diseases, infections and injuries that are characterized by localized or systemic inflammatory responses and associated with or mediated or modulated by TNF.
Household appliance, comprising a control panel and a control unit and a touch display connected to said control unit, whereby said control unit is configured to contemporaneously display a plurality of operating functions on said touch display and to receive and to process user input, wherein said touch display displays a plurality of operating functions, among them a highlighted operating function, whereby each of said displayed operating functions is selectable by touching it at least one time, characterized in that on the control panel a rotary knob is arranged, whereby turning the knob allows changing the highlighted operating function.
Method for determining the permeation rate of barrier materials, wherein in a measuring chamber (8.7) which has at least two shut-off elements (8.1; 8.2) for opening and closing, a concentration of at least one permeate is determined which, present as a test gas with a constant concentration in a test gas chamber (8.3), is permeated into the measuring chamber (8.7) through a barrier element (8.5) which is arranged between the test gas chamber (8.3) and the measuring chamber (8.7) and which has a known permeable surface; wherein in a process step (i), the measuring chamber (8.7) is purged with a constant permeate-free purge gas volume flow ( V̇) by opening the shut-off elements (8.1; 8.2) once a predefinable upper switchover concentration (cvA) has been reached in a first measurement variant or once a predefinable enriching time (tvA) has been reached in the second measuring variant; wherein the permeate concentration (c) in the open measuring chamber (8.7) drops as a result of the purging; and the time course of this permeate concentration (c) is either determined up to the reaching of a predefinable lower switchover concentration (cvS) in the first measurement variant, with a purge time (tS) being determined in this respect, or up to the reaching of a predefinable purge time (tvS) in the second measurement variant; and in a process step (ii), on reaching the predefinable lower switchover concentration (cvS) in the first measurement variant or on reaching the predefinable purge time (tvS) in the second measurement variant, the measuring chamber (8.7) is closed by closing the shut-off elements (8.1; 8.2), wherein the permeate concentration (c) increases in the closed measuring chamber (8.7) as a result of the permeation, with an enriching time (tA) up to the reaching of the predefinable upper switchover concentration (cvA) being determined in the first measurement variant; and subsequently using the enriching time (tA) and using the purge time (tS) determined in process step (i) using the first measurement variant and using the course of the permeate concentration (c) determined during the purge time (tS), or using the course of the permeate concentration (c) determined during the predefinable purge time (tvS) using the second measurement variant in process step (i) and using the predefinable purge time (tvS) and the predefinable enriching time (tvA), the permeation rate of the barrier element (8.5) is calculated using the equation P = ∫ c t ⋅ V ̇ dt ⋅ M ⋅ p R ⋅ T ⋅ t total ⋅ A where t total is the sum of the purge time (tS) and of the enriching time (tA) for the first measurement variant and is the sum of the predefinable purge time (tvS) and of the predefinable enriching time (TvA) for the second measurement variant; M is the molar mass of the permeate; p is the maintained pressure, R is the general gas constant; and T is the temperature maintained during process steps (i) and (ii).