A combination of: - a time-temperature indicator for monitoring the quality state of a thermally sensitive article, comprising two laminated portions: an indication function layer and an adsorption function layer; - said thermally sensitive article, Characterized in that the indication function layer and the adsorption function layer are physically independent of each other before use, wherein: the indication function layer comprises: a first substrate material layer; a volatile dye layer, which is coated on one side of the first substrate material layer, wherein the difference between the activation energy of volatilization process of the volatile dye layer and that of quality change process of the thermally sensitive article is in a predetermined range of ±10 kJ/mol, and the activation energy of the volatilization process of the volatile dye layer is 60-140 kJ/mol; and a first release film layer, which covers the volatile dye layer, wherein the first substrate material layer and the first release film layer are larger than the volatile dye layer in dimension, and the volatile dye layer is sealed between the first substrate material layer and the first release film layer; the adsorption function layer comprises: a second substrate material layer; an adsorption material layer, which is coated on one side of the second substrate material layer, wherein the adsorption material layer is larger than the volatile dye layer in dimension, preferably the adsorption material can irreversibly adsorb the dye volatilized from the volatile dye layer, and more preferably the rate of the adsorption in which the adsorption material adsorbs the volatile dye is much higher than the volatilization rate of the volatile dye; an adhesive layer, which is coated on the second substrate material layer, and surrounds the periphery of the adsorption material layer; a second release film layer, which covers the adhesive layer and the adsorption material layer; and the thermally sensitive article is an article which needs to be stored and/or transported at a temperature in the range from -40 °C to 50 °C, and selected from vaccines, biological articles, bioactive samples, medicines, food or drinks. - a time-temperature indicator for monitoring the quality state of a thermally sensitive article, comprising two laminated portions: an indication function layer and an adsorption function layer; - said thermally sensitive article, the indication function layer comprises: a first substrate material layer; a volatile dye layer, which is coated on one side of the first substrate material layer, wherein the difference between the activation energy of volatilization process of the volatile dye layer and that of quality change process of the thermally sensitive article is in a predetermined range of ±10 kJ/mol, and the activation energy of the volatilization process of the volatile dye layer is 60-140 kJ/mol; and a first release film layer, which covers the volatile dye layer, wherein the first substrate material layer and the first release film layer are larger than the volatile dye layer in dimension, and the volatile dye layer is sealed between the first substrate material layer and the first release film layer; the adsorption function layer comprises: a second substrate material layer; an adsorption material layer, which is coated on one side of the second substrate material layer, wherein the adsorption material layer is larger than the volatile dye layer in dimension, preferably the adsorption material can irreversibly adsorb the dye volatilized from the volatile dye layer, and more preferably the rate of the adsorption in which the adsorption material adsorbs the volatile dye is much higher than the volatilization rate of the volatile dye; an adhesive layer, which is coated on the second substrate material layer, and surrounds the periphery of the adsorption material layer; a second release film layer, which covers the adhesive layer and the adsorption material layer; and the thermally sensitive article is an article which needs to be stored and/or transported at a temperature in the range from -40 °C to 50 °C, and selected from vaccines, biological articles, bioactive samples, medicines, food or drinks. a second substrate material layer; an adsorption material layer, which is coated on one side of the second substrate material layer, wherein the adsorption material layer is larger than the volatile dye layer in dimension, preferably the adsorption material can irreversibly adsorb the dye volatilized from the volatile dye layer, and more preferably the rate of the adsorption in which the adsorption material adsorbs the volatile dye is much higher than the volatilization rate of the volatile dye; an adhesive layer, which is coated on the second substrate material layer, and surrounds the periphery of the adsorption material layer; a second release film layer, which covers the adhesive layer and the adsorption material layer; and the thermally sensitive article is an article which needs to be stored and/or transported at a temperature in the range from -40 °C to 50 °C, and selected from vaccines, biological articles, bioactive samples, medicines, food or drinks.