mhurhangee/ep-ind-claims huggingface dataset:
A method of screening an antigen-binding molecule that has a lower antigen-binding activity under a low calcium concentration condition than under a high calcium concentration condition, wherein the antigen-binding molecule comprises an antibody variable region comprising a light chain variable region in which any one or more of the amino acids at positions 30, 31, 32, 50, and 92 according to Kabat's numbering system has metal chelating activity, which amino acids are selected from the group consisting of serine, threonine, asparagine, glutamine, aspartic acid, glutamic acid, histidine, and tyrosine, wherein the method comprises the steps of (a) to (c) below: (a) determining the antigen-binding activity of the antigen-binding molecule under a low calcium concentration condition; (b) determining the antigen-binding activity of the antigen-binding molecule under a high calcium concentration condition; and (c) selecting the antigen-binding molecule that has a lower antigen-binding activity under the low calcium concentration condition than under the high calcium concentration condition, wherein the low calcium concentration is an ionized calcium concentration of 0.1 to 30 μM, and the high calcium concentration is an ionized calcium concentration of 100 μM to 10 mM. wherein the antigen-binding molecule comprises an antibody variable region comprising a light chain variable region in which any one or more of the amino acids at positions 30, 31, 32, 50, and 92 according to Kabat's numbering system has metal chelating activity, which amino acids are selected from the group consisting of serine, threonine, asparagine, glutamine, aspartic acid, glutamic acid, histidine, and tyrosine, wherein the method comprises the steps of (a) to (c) below: (a) determining the antigen-binding activity of the antigen-binding molecule under a low calcium concentration condition; (b) determining the antigen-binding activity of the antigen-binding molecule under a high calcium concentration condition; and (c) selecting the antigen-binding molecule that has a lower antigen-binding activity under the low calcium concentration condition than under the high calcium concentration condition, (a) determining the antigen-binding activity of the antigen-binding molecule under a low calcium concentration condition; (b) determining the antigen-binding activity of the antigen-binding molecule under a high calcium concentration condition; and (c) selecting the antigen-binding molecule that has a lower antigen-binding activity under the low calcium concentration condition than under the high calcium concentration condition, wherein the low calcium concentration is an ionized calcium concentration of 0.1 to 30 μM, and the high calcium concentration is an ionized calcium concentration of 100 μM to 10 mM.
A catheter comprising: a hollow shaft (10, 210, 310, 410, 510); at least one adhering portion (60, 61, 62, 260, 360, 460) provided on an outer surface of the shaft (10, 210, 310, 410, 510); and a plurality of protrusions (70, 270, 370, 570) arranged on the at least one adhering portion (60, 61, 62, 260, 360, 460), characterized in that at least one adhering portion is provided in a concave portion formed on the outer surface of the shaft. a hollow shaft (10, 210, 310, 410, 510); at least one adhering portion (60, 61, 62, 260, 360, 460) provided on an outer surface of the shaft (10, 210, 310, 410, 510); and a plurality of protrusions (70, 270, 370, 570) arranged on the at least one adhering portion (60, 61, 62, 260, 360, 460), characterized in that at least one adhering portion is provided in a concave portion formed on the outer surface of the shaft.
Apparatus (1, 10) for producing cooled coffee including a brewing unit for producing coffee, a cooling unit and a coffee cooler constructed as a heat exchanger, wherein the coffee cooler has at least one first and one second flow path, which are thermally but not fluid conductively connected, wherein a cooling medium can flow through the first flow path and the second flow path is fluid conductively connected to a coffee outlet of the brewing unit, characterised in that the apparatus further includes a fresh water inlet and a fresh water cooler constructed as a further heat exchanger, wherein the fresh water cooler has at least one first and one second flow path, which are thermally but not fluid conductively connected, and the fresh water inlet is fluid conductively connected downstream to the second flow path of the fresh water cooler, further downstream to the first flow path of the coffee cooler and further downstream to the brewing unit and the first flow path of the fresh water cooler is fluid conductively connected to a cooling medium circuit of the cooling unit.
A derivative of formula: (MO 2) - (A m+) y wherein: M is a Si or Ti atom; (MO 2) - represents an anionic dioxide particle comprising tetrahedral Silicon or octahedral Titanium atoms interconnected through bridging oxygen atoms, A m+ represents a chlorhexidine cation and a cationic silver complex of formula Ag-L, having L preferably selected from: optionally substituted 8-mercapto-quinoline hydrochloride and 2-mercapto-4-(C 1 -C 6 Alk)pyrimidine hydrochloride, A m+ being linked to the anionic dioxide particle by electrostatic interaction, wherein m represents the charge of said active species, and is comprised from 1 to 20, preferably from 1 to 10, Y represents the number of different active species A m+ co-adsorbed to the same anionic silicon or titanium dioxide particle, and it is equal to 2. M is a Si or Ti atom; (MO 2) - represents an anionic dioxide particle comprising tetrahedral Silicon or octahedral Titanium atoms interconnected through bridging oxygen atoms, A m+ represents a chlorhexidine cation and a cationic silver complex of formula Ag-L, having L preferably selected from: optionally substituted 8-mercapto-quinoline hydrochloride and 2-mercapto-4-(C 1 -C 6 Alk)pyrimidine hydrochloride, A m+ being linked to the anionic dioxide particle by electrostatic interaction, wherein m represents the charge of said active species, and is comprised from 1 to 20, preferably from 1 to 10, Y represents the number of different active species A m+ co-adsorbed to the same anionic silicon or titanium dioxide particle, and it is equal to 2.
A superconductor tape comprising: a substrate; a buffer layer overlying the substrate; and a RE-Ba-Cu-O superconductor film overlying the buffer layer; characterized in that the superconductor film is defined as having a c-axis lattice constant higher than 11.74 Angstroms, and the superconductor film has a critical current at 77 K in zero magnetic field. a substrate; a buffer layer overlying the substrate; and a RE-Ba-Cu-O superconductor film overlying the buffer layer; characterized in that the superconductor film is defined as having a c-axis lattice constant higher than 11.74 Angstroms, and the superconductor film has a critical current at 77 K in zero magnetic field.
A computing system (100, 400), comprising: a processor; a sensor (124, 412) to collect environmental data relative to the computing system and an environment surrounding the computing system; and a depth sensor (126, 414) to collect depth data in response to a determination by the processor of a movement of the computing system in the environment, wherein the determination of the movement is based on the collected environmental data from the sensor (124, 412). a processor; a sensor (124, 412) to collect environmental data relative to the computing system and an environment surrounding the computing system; and a depth sensor (126, 414) to collect depth data in response to a determination by the processor of a movement of the computing system in the environment, wherein the determination of the movement is based on the collected environmental data from the sensor (124, 412).
A multi-axis gyroscope, comprising a microelectromechanical structure including a driving mass anchored to a substrate via elastic anchoring elements (18a, 18b) and extending in a plane (xy) parallel to the substrate, and designed to be actuated with a driving movement at a resonance frequency; the microelectromechanical structure having a pitch reference axis (x) and a roll reference axis (y) lying in said plane (xy), along which respectively a pitch angular velocity (Ω x) and a roll angular velocity (Ω y) are designed to act, and further comprises a first pair of sensing masses (22a, 22c) and a second pair of sensing masses (22b, 22d) suspended within, and coupled to, said driving mass via respective elastic supporting elements, so as to be fixed with respect to said driving mass in said driving movement and perform a respective detection movement in response to said pitch (Ω x) and roll (Ω y) angular velocities; said first pair of sensing masses (22a, 22c) being sensitive in a first detection direction (x 1) of said plane (xy), and said second pair of sensing masses being sensitive in a second detection direction (x 2) of said plane (xy), said first (x 1) and second (x 2) detection directions being inclined by an inclination angle (Φ) comprised between 40° and 50° with respect to said pitch (x) and roll (y) reference axes, said first (22a, 22c) and second (22b, 22d) pair of sensing masses being configured to generate respective detection capacitive variations as a function of projections of said pitch (Ω x) and roll (Ω y) angular velocities in said first (x 1) and second (x 2) detection directions; said gyroscope further comprising a reading circuit (30, 30') coupled to the microelectromechanical structure, characterized in that said reading circuit (30, 30') includes a combination stage (32, 32') configured to perform an electrical combination of detection capacitive variations generated by the sensing masses of said first (22a, 22c) and second (22b, 22d) pairs, as a function of said inclination angle (Φ), in order to generate electrical output signals, each correlated to a respective one of said pitch (Ω x) and roll (Ω y) angular velocities.
A system comprising a circuit under test and an apparatus for on-chip reconstruction of transient settling behavior, wherein the apparatus comprises: a first sampling means adapted to sample a tracked analog signal output from the circuit under test over an operating period at a first sampling time ( t 1) thereby generating a first sample output, a second sampling means adapted to sample the said tracked analog signal output at a second sampling time ( t 2) thereby generating a second sample output, a signal subtraction means adapted to perform subtraction of the first sample output and the second sample output thereby generating a difference signal, and a signal conversion means adapted to output the difference signal in digital domain, the system being characterized in that, the circuit under test is a discrete time switched capacitor circuit comprising an amplifier, and that the tracked analog signal output corresponds to a transient waveform output from the amplifier, whereby the first sample output represents a transient value at an arbitrary time instant and the second sample output represents a final transient value of the transient waveform over the operating period. settling behavior, wherein the apparatus comprises: a first sampling means adapted to sample a tracked analog signal output from the circuit under test over an operating period at a first sampling time ( t 1) thereby generating a first sample output, a second sampling means adapted to sample the said tracked analog signal output at a second sampling time ( t 2) thereby generating a second sample output, a signal subtraction means adapted to perform subtraction of the first sample output and the second sample output thereby generating a difference signal, and a signal conversion means adapted to output the difference signal in digital domain, the system being characterized in that, the circuit under test is a discrete time switched capacitor circuit comprising an amplifier, and that the tracked analog signal output corresponds to a transient waveform output from the amplifier, whereby the first sample output represents a transient value at an arbitrary time instant and the second sample output represents a final transient value of the transient waveform over the operating period.
A clothes dryer using far-infrared heating, comprising a clothes-drying drum, and further comprising far-infrared heaters, a humidity sensor for detecting exhaust humidity of the clothes-drying drum, characterized by a relay and a controller having an output end connected with the relay; wherein all the far-infrared heaters are connected with a power supply through the relay; a first temperature sensor is mounted inside one of the far-infrared heaters; the first temperature sensor and the humidity sensor are connected with an input end of the controller; and the controller controls on and off of the relay according to a received temperature signal or humidity signal; the far-infrared heaters are made of tin ceramic membrane materials.
Arrangement suitable for a motor vehicle, comprising a casing, in particular of the engine block type, having first and second parts (16, 17) that are fastened to one another so as to be able to enclose a fluid in an internal environment of the casing, in particular oil for lubricating a mobile linkage located in the internal environment, at least one functional member located in the internal environment, at least one seal, in particular in the form of a flat gasket, intended to establish a seal with respect to a fluid at the interface between the first and second parts (16, 17) when the first and second parts (16, 17) are fastened to one another, the seal comprising, over all or part of its length, clamping elements fastening on to the seal all or part of at least one wiring harness that is suitable for establishing an electrical connection through the casing between the functional member located in the internal environment bounded by the casing and electrical wiring arranged in an environment outside the casing, the clamping elements comprising a plurality of holding tabs that are bent so as to be folded down around the wiring harness, staggered along all or part of the length of the seal considered at the interface between the first and second parts (16, 17) of the casing that are fastened to one another, characterized in that the clamping elements are configured so as to detachably fasten the wiring harness to the seal, the clamping elements being deformable between a bent position so as to cover the wiring harness by wrapping approximately three-quarters of the way around it, and a straightened position in which the clamping elements extend essentially linearly from that part of the seal that is intended to seal the first and second parts (16, 17).
Cooling device for a converter of a high-voltage direct-current transmission system comprising at least one heat sink, which has a cooling channel, comprising a cooling water distributor, which is fluidically connected to the cooling channel by way of a heat-sink supply line, the cooling channel, the cooling water distributor and the heat-sink supply line being flowed through by a cooling fluid and being part of a system of cooling lines of the cooling device, and comprising at least one control electrode, which at least in certain regions is arranged within the cooling fluid, characterized in that the at least one heat sink is formed from aluminium and the system of cooling lines has at least one line element (10, 20) that is permeable to carbon dioxide.
A liquid electrolyte formulation for a lithium metal secondary battery comprising: - a conductive lithium salt which is selected from the group comprising LiTFSI, LiFSI, LiCl, LiF, LiCN, LiC 2 N 3, LiN 3, LiNO 2, LiNO 3, LiBF 4, LiPF 6, LiAsF 6, LiSbF 6, LiAlCl 4, - a first ionic liquid having the formula (CATION)FSI, wherein CATION is selected from the group comprising alkyl pyrollidinium and alkyl piperidinium, - a second ionic liquid as anti-corrosion agent, said second ionic liquid having the formula (CATION)(ANION) where (CATION) is defined as above and (ANION) is an anion comprising at least one nitrile functionality. - a conductive lithium salt which is selected from the group comprising LiTFSI, LiFSI, LiCl, LiF, LiCN, LiC 2 N 3, LiN 3, LiNO 2, LiNO 3, LiBF 4, LiPF 6, LiAsF 6, LiSbF 6, LiAlCl 4, - a first ionic liquid having the formula (CATION)FSI, wherein CATION is selected from the group comprising alkyl pyrollidinium and alkyl piperidinium, - a second ionic liquid as anti-corrosion agent, said second ionic liquid having the formula (CATION)(ANION) where (CATION) is defined as above and (ANION) is an anion comprising at least one nitrile functionality.
A method for producing a polycarbonate resin, comprising a step of performing polycondensation through a transesterification reaction in the presence of a transesterification catalyst by using a dihydroxy compound as a raw material compound and a carbonic acid diester, wherein: the dihydroxy compound comprises at least an aliphatic dihydroxy compound having an etheric oxygen atom on at least one β-position or γ-position of a hydroxy group, and the aliphatic dihydroxy compound comprises at least a compound represented by the following formula: the raw material compound comprises a nitrogen-containing compound in an amount of 0.3 ppm to less than 10 ppm in terms of weight concentration of nitrogen atom based on the aliphatic dihydroxy compound, the raw material compound comprises a sodium compound and the content of the sodium compound is less than 2 ppm in terms of weight concentration of sodium atom based on the aliphatic dihydroxy compound, the transesterification catalyst is at least one metal compound selected from metals belonging to Group 2 of the long-form periodic table, the production method of a polycarbonate resin comprises a step of previously heating the aliphatic dihydroxy compound at 50°C or more, holding the compound in the melted state for 0.5 to 200 hours, and then mixing the melt with a carbonic acid diester, and the maximum temperature of the reaction solution is less than 250°C at all reaction stages. the dihydroxy compound comprises at least an aliphatic dihydroxy compound having an etheric oxygen atom on at least one β-position or γ-position of a hydroxy group, and the aliphatic dihydroxy compound comprises at least a compound represented by the following formula: the raw material compound comprises a nitrogen-containing compound in an amount of 0.3 ppm to less than 10 ppm in terms of weight concentration of nitrogen atom based on the aliphatic dihydroxy compound, the raw material compound comprises a sodium compound and the content of the sodium compound is less than 2 ppm in terms of weight concentration of sodium atom based on the aliphatic dihydroxy compound, the transesterification catalyst is at least one metal compound selected from metals belonging to Group 2 of the long-form periodic table, the production method of a polycarbonate resin comprises a step of previously heating the aliphatic dihydroxy compound at 50°C or more, holding the compound in the melted state for 0.5 to 200 hours, and then mixing the melt with a carbonic acid diester, and the maximum temperature of the reaction solution is less than 250°C at all reaction stages.
A controller, comprising a control part operating on a general-purpose operating system and a real-time operating system for controlling a control object, the controller comprising: a first data managing part, configured to perform acquisition processing of periodically input first data by an application program (42, 412) operating on the general-purpose operating system; a first buffer memory in which the first data is memorized by the first data managing part; a second data managing part, configured to exchange data with the first data managing part by an application program operating on the real-time operating system for controlling the control object; a second buffer memory in which data is memorized by the second data managing part, a power interruption detecting part configured to detect power interruption of the control part; and a second nonvolatile memory, characterized in that the first data managing part, configured to transmit the acquired first data to the second data managing part as mirroring data, and the second data managing part, configured to memorize the mirroring data in the second buffer memory, wherein the mirroring data of the second buffer memory are stored in the second nonvolatile memory upon a detection of power interruption. a first data managing part, configured to perform acquisition processing of periodically input first data by an application program (42, 412) operating on the general-purpose operating system; a first buffer memory in which the first data is memorized by the first data managing part; a second data managing part, configured to exchange data with the first data managing part by an application program operating on the real-time operating system for controlling the control object; a second buffer memory in which data is memorized by the second data managing part, a power interruption detecting part configured to detect power interruption of the control part; and a second nonvolatile memory, characterized in that the first data managing part, configured to transmit the acquired first data to the second data managing part as mirroring data, and the second data managing part, configured to memorize the mirroring data in the second buffer memory, wherein the mirroring data of the second buffer memory are stored in the second nonvolatile memory upon a detection of power interruption.
Anchoring shell for an artificial acetabulum, having a hemispherical or virtually hemispherical external geometry, which bears a toothed structure on the outer side of the half-shell, said toothed structure being arranged annularly with respect to the component axis, wherein tooth cutting edges of the teeth are arranged spatially perpendicularly to the component axis, wherein a tooth flank, oriented towards the equator, of the individual teeth forms an angle of less than ninety degrees with the component axis in a clamping region, close to the equator, of the anchoring shell, such that a barb effect arises in the direction of the equator, wherein a tooth flank, oriented towards the pole, of the individual teeth forms an angle of more than one hundred and ten degrees with the component axis in the clamping region of the anchoring shell, wherein a path curve (22, 23) of a producing tool which produces tooth gaps is single-curved and thus is a spatially projected straight line, and is formed such that the teeth are arranged in a staggered manner from one row of teeth to the next, and the tooth cutting edges of two teeth that follow one another from the equator in the direction of the pole do not overlap or overlap at most by 0.2 mm.
A method for regulating a motor having a plurality of operating speeds, operating speed being determined in accordance with a speed change criterion, the method comprising a step of correcting the speed change criterion based on three parameters which are the voltage, temperature and the frequency applied to the motor.