An impact and crush resistant shipping container (200, 300, 400, 500) comprising: at least one vial and cap assembly, the at least one vial and cap assembly having an assembly height (h 1), a first width (w 1) and an indentation having a second width (w 2) less than the first width (w 1), the indentation located intermediate the assembly height (h 1), the vial and cap assembly comprising an un-activated position and an activated position and the vial and cap assembly being activatable by an action comprising a reduction of the assembly height; an outer body (314, 420) having sides (422, 424) and a bottom defining a cavity and an opening, the cavity having a depth (d 1), the body further comprising a closeable cover (208, 308, 408) for enclosing the cavity; a partitioning divider (416, 516) defining at least one vertically extending receptacle (312, 412, 512) for receiving at least a portion of the at least one vial and cap assembly, the receptacle (312, 412, 512) having a depth greater than the assembly height (h 1) the partitioning divider (416, 516) having a height (h 3) less than the depth (d 1) of the cavity; an insert (204, 304, 404, 504(a), 504(b), 504(c)) having at least one opening (206, 306, 406, 506) therethrough for receiving the at least one vial and cap assembly, each opening having a width greater than the second width (w 2) and less than the first width (w 1) of the at least one vial and cap assembly such that the at least one vial and cap assembly is suspended in the opening (206, 306, 406, 506) of the insert (204, 304, 404, 504(a), 504(b), 504(c)) at the indentation, wherein the partitioning divider (416, 516) is positioned in relation to the insert (204, 304, 404, 504(a), 504(b), 504(c)) such that the at least one vial and cap assembly is suspended at least partially within the receptacle, wherein the partitioning divider (416, 516) and the insert (204, 304, 404, 504(a), 504(b), 504(c)) with the at least one vial and cap assembly suspended therein are positioned within the cavity such that the cover (208, 308, 408) can be closed without contacting the at least one vial and cap assembly, wherein the opening (206, 306, 406, 506) in the insert (204, 304, 404, 504(a), 504(b), 504(c)) further comprises a frangible or deformable portion, wherein if a sufficient force is applied to the vial and cap assembly, the vial and cap assembly can be pushed through the opening (206, 306, 406, 506) and pass into the receptacle (312, 412, 512) by breaking or deforming the frangible or deformable portion and the receptacle depth is sufficient to avoid contact between the broken or deformed portion sufficient to activate the vial and cap assembly when the vial and cap assembly has passed into the receptacle (312, 412, 512). at least one vial and cap assembly, the at least one vial and cap assembly having an assembly height (h 1), a first width (w 1) and an indentation having a second width (w 2) less than the first width (w 1), the indentation located intermediate the assembly height (h 1), the vial and cap assembly comprising an un-activated position and an activated position and the vial and cap assembly being activatable by an action comprising a reduction of the assembly height; an outer body (314, 420) having sides (422, 424) and a bottom defining a cavity and an opening, the cavity having a depth (d 1), the body further comprising a closeable cover (208, 308, 408) for enclosing the cavity; a partitioning divider (416, 516) defining at least one vertically extending receptacle (312, 412, 512) for receiving at least a portion of the at least one vial and cap assembly, the receptacle (312, 412, 512) having a depth greater than the assembly height (h 1) the partitioning divider (416, 516) having a height (h 3) less than the depth (d 1) of the cavity; an insert (204, 304, 404, 504(a), 504(b), 504(c)) having at least one opening (206, 306, 406, 506) therethrough for receiving the at least one vial and cap assembly, each opening having a width greater than the second width (w 2) and less than the first width (w 1) of the at least one vial and cap assembly such that the at least one vial and cap assembly is suspended in the opening (206, 306, 406, 506) of the insert (204, 304, 404, 504(a), 504(b), 504(c)) at the indentation, wherein the partitioning divider (416, 516) is positioned in relation to the insert (204, 304, 404, 504(a), 504(b), 504(c)) such that the at least one vial and cap assembly is suspended at least partially within the receptacle, wherein the partitioning divider (416, 516) and the insert (204, 304, 404, 504(a), 504(b), 504(c)) with the at least one vial and cap assembly suspended therein are positioned within the cavity such that the cover (208, 308, 408) can be closed without contacting the at least one vial and cap assembly, wherein the opening (206, 306, 406, 506) in the insert (204, 304, 404, 504(a), 504(b), 504(c)) further comprises a frangible or deformable portion, wherein if a sufficient force is applied to the vial and cap assembly, the vial and cap assembly can be pushed through the opening (206, 306, 406, 506) and pass into the receptacle (312, 412, 512) by breaking or deforming the frangible or deformable portion and the receptacle depth is sufficient to avoid contact between the broken or deformed portion sufficient to activate the vial and cap assembly when the vial and cap assembly has passed into the receptacle (312, 412, 512).