An analyte measurement device, comprising: electrical circuitry connected to a sensor interface, the electrical circuitry including a processor connected to a signal generator and a storage medium, the processor being adapted to: measure at least two analyte responsive output signals (412, 414) from the sample; determine at least two initial analyte concentrations from the two analyte responsive output signals (412, 414); determine a first pseudo-reference concentration from the two analyte responsive output signals (412, 414), the first pseudo-reference concentration being a first substitute for true relative error; determine at least two first anchor parameters in response to the first pseudo-reference concentration, the two first anchor parameters compensating for system error; incorporate the two first anchor parameters into at least two first compensation relationships, at least one of the two first compensation relationships including Ach1_comp = Ach1initial/(1 + RECh1), Ch1 being channel 1, Ach1_comp being the anchor parameter compensated analyte concentration determined for channel 1, Ach1 initial being the initial analyte concentration determined for channel 1; determine at least two first anchor compensated analyte concentrations in response to the two initial analyte concentrations, the two first anchor parameters, and the two first compensation relationships; determine a second pseudo-reference concentration by averaging the two first anchor compensated analyte concentrations, the second pseudo-reference concentration being a second substitute for true relative error; and report the second pseudo-reference concentration as a final compensated analyte concentration of the sample. measure at least two analyte responsive output signals (412, 414) from the sample; determine at least two initial analyte concentrations from the two analyte responsive output signals (412, 414); determine a first pseudo-reference concentration from the two analyte responsive output signals (412, 414), the first pseudo-reference concentration being a first substitute for true relative error; determine at least two first anchor parameters in response to the first pseudo-reference concentration, the two first anchor parameters compensating for system error; incorporate the two first anchor parameters into at least two first compensation relationships, at least one of the two first compensation relationships including Ach1_comp = Ach1initial/(1 + RECh1), Ch1 being channel 1, Ach1_comp being the anchor parameter compensated analyte concentration determined for channel 1, Ach1 initial being the initial analyte concentration determined for channel 1; determine at least two first anchor compensated analyte concentrations in response to the two initial analyte concentrations, the two first anchor parameters, and the two first compensation relationships; determine a second pseudo-reference concentration by averaging the two first anchor compensated analyte concentrations, the second pseudo-reference concentration being a second substitute for true relative error; and report the second pseudo-reference concentration as a final compensated analyte concentration of the sample.