mhurhangee/ep-ind-claims huggingface dataset:
A cyclopeptide of formula II: wherein each R 1 is independently selected from the group consisting of a side chain of a natural amino acid and a side chain of an unnatural amino acid, wherein the natural amino acid and the unnatural amino acid is either-in the D or L form; R 2 and R 3 are each independently selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl, and alkynyl groups are each optionally substituted, wherein R 2 and R 3 are not both H; and either R 2 or R 3, or both R 2 and R 3 comprise a radionuclide selected from the group consisting of 11 C, 13 N, 15 O, 18 F, 75 Br, 124 I, 125 I and 131 I; and W is where p is an integer between 0 and 15; v is 0, 1, 2, or 3; m is 0, 1 or 2; each R 4 is independently selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl, and alkynyl groups are each optionally substituted; and R 5 is selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl and alkynyl groups are each optionally substituted and wherein the configuration of the chiral center that carries the R 5 substituent may be R or S or mixtures thereof. each R 1 is independently selected from the group consisting of a side chain of a natural amino acid and a side chain of an unnatural amino acid, wherein the natural amino acid and the unnatural amino acid is either-in the D or L form; R 2 and R 3 are each independently selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl, and alkynyl groups are each optionally substituted, wherein R 2 and R 3 are not both H; and either R 2 or R 3, or both R 2 and R 3 comprise a radionuclide selected from the group consisting of 11 C, 13 N, 15 O, 18 F, 75 Br, 124 I, 125 I and 131 I; and W is where p is an integer between 0 and 15; v is 0, 1, 2, or 3; m is 0, 1 or 2; each R 4 is independently selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl, and alkynyl groups are each optionally substituted; and R 5 is selected from the group consisting of -H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, and C 2 -C 6 alkynyl, wherein the alkyl, alkenyl and alkynyl groups are each optionally substituted and wherein the configuration of the chiral center that carries the R 5 substituent may be R or S or mixtures thereof.
Electronic wrist or pocket watch (1,1',1"), comprising - a case, - display means for displaying a plurality of symbols, - processing means in signal communication with the display means, and configured for controlling said display means in a manner such that they will display a screen where at least one first symbol is selected among a plurality of available symbols, - a rotary crown (3,3',3") associated with the case, and motion detection means (13,13',18) configured for detecting at least the rotary motion of said crown (3,3',3"), wherein said motion detection means (13,13') are in signal communication with the processing means, and wherein said processing means are also configured for controlling the display means in a manner such that, when the crown (3,3',3") is turned, at least one other symbol, different from the first symbol, will be selected among the plurality of available symbols, characterized in that the crown (3',3") is also configured in a manner such that it can be moved along the axis of rotation of said crown (3',3"), so that it can be extracted from the case, wherein the motion detection means comprise a translation sensor in signal communication with the processing means, and configured for detecting the extraction of the crown (3',3") from the case, and wherein the processing means are also configured for activating an application associated with the selected symbol when the translation sensor detects the extraction of the crown (3',3") from the case. - a case, - display means for displaying a plurality of symbols, - processing means in signal communication with the display means, and configured for controlling said display means in a manner such that they will display a screen where at least one first symbol is selected among a plurality of available symbols, - a rotary crown (3,3',3") associated with the case, and motion detection means (13,13',18) configured for detecting at least the rotary motion of said crown (3,3',3"), wherein said motion detection means (13,13') are in signal communication with the processing means, and wherein said processing means are also configured for controlling the display means in a manner such that, when the crown (3,3',3") is turned, at least one other symbol, different from the first symbol, will be selected among the plurality of available symbols,
A multilayer construct comprising: at least two fibrillar nanoweave biopolymer layers attached by intermediate biodegradable layer where the intermediate layer has a rate of degradation higher than at least one nanoweave biopolymer layer under physiological conditions, wherein at least one of the two biopolymer layers is a cross-linked fibrillar nanoweave collagen layer.
A system for displaying inspection data collected from a furnace with a specified physical geometry, wherein said furnace comprises a plurality of tube segments interconnected by a plurality of bends so as to allow stacking of said tube segments, said system comprising: an inspection tool configured to collect inspection data comprising a plurality of inside radius and/or wall thickness readings and configured to be flushed through the furnace; a storage device for storing said inspection data; and a computer; characterized in that the inspection tool comprises an array of ultrasonic transducers or a single transducer with a rotating mirror; and wherein the computer is programmed to: generate data markers based upon an analysis of the inspection data collected from the furnace, each of which data markers identifies a location of a physical feature of said furnace; partition said inspection data at the data markers so as to correlate said inspection data to said physical geometry of said furnace; and generate a display of said partitioned inspection data arranged to represent said physical geometry of a plurality of said tube segments to thereby enable visual detection of a problem area comprising one or more of said tube segments within said furnace. an inspection tool configured to collect inspection data comprising a plurality of inside radius and/or wall thickness readings and configured to be flushed through the furnace; a storage device for storing said inspection data; and a computer; characterized in that the inspection tool comprises an array of ultrasonic transducers or a single transducer with a rotating mirror; and an array of ultrasonic transducers or a single transducer with a rotating mirror; and wherein the computer is programmed to: generate data markers based upon an analysis of the inspection data collected from the furnace, each of which data markers identifies a location of a physical feature of said furnace; partition said inspection data at the data markers so as to correlate said inspection data to said physical geometry of said furnace; and generate a display of said partitioned inspection data arranged to represent said physical geometry of a plurality of said tube segments to thereby enable visual detection of a problem area comprising one or more of said tube segments within said furnace. generate data markers based upon an analysis of the inspection data collected from the furnace, each of which data markers identifies a location of a physical feature of said furnace; partition said inspection data at the data markers so as to correlate said inspection data to said physical geometry of said furnace; and generate a display of said partitioned inspection data arranged to represent said physical geometry of a plurality of said tube segments to thereby enable visual detection of a problem area comprising one or more of said tube segments within said furnace.
A metallocene-catalysed multimodal polyethylene copolymer, which consists of (i) 35.0 to 50.0 wt% of an ethylene-1-butene polymer component, and (ii) 50.0 to 65.0 wt% of an ethylene-1-hexene polymer component, whereby the ethylene-1-butene polymer component has a density in the range of from 937 to 943 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 3.5 to 8.5 g/10 min and a 1-butene content in the range of from 0.5 to 2.5 wt%, based on the ethylene-1-butene polymer component; and the ethylene polymer component has a density in the range of from 885 to 900 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 0.05 to 1.5 g/10 min and a 1-hexene content in the range of from 15.5 to 22.0 wt%, based on the ethylene-1-hexene polymer compound, whereby the 1-hexene content follows the equation 30.13 − 0.1621 * B wt % ≥ C 6 wt % ≥ 26.25 − 0.1621 * B wt % whereby the multimodal polyethylene copolymer has a density in the range of from 908 to 918 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 0.2 to 2.6 g/10 min and a sealing initiation temperature, determined on a 40 μm test blown film as described in the experimental part, in the range of 60°C to ≤ 75°C. (i) 35.0 to 50.0 wt% of an ethylene-1-butene polymer component, and (ii) 50.0 to 65.0 wt% of an ethylene-1-hexene polymer component, whereby the ethylene-1-butene polymer component has a density in the range of from 937 to 943 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 3.5 to 8.5 g/10 min and a 1-butene content in the range of from 0.5 to 2.5 wt%, based on the ethylene-1-butene polymer component; and the ethylene polymer component has a density in the range of from 885 to 900 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 0.05 to 1.5 g/10 min and a 1-hexene content in the range of from 15.5 to 22.0 wt%, based on the ethylene-1-hexene polymer compound, whereby the 1-hexene content follows the equation 30.13 − 0.1621 * B wt % ≥ C 6 wt % ≥ 26.25 − 0.1621 * B wt % whereby the multimodal polyethylene copolymer has a density in the range of from 908 to 918 kg/m3, an MFR 2, determined at 190°C, 2.16 kg, according to ISO 1133, in the range of from 0.2 to 2.6 g/10 min and a sealing initiation temperature, determined on a 40 μm test blown film as described in the experimental part, in the range of 60°C to ≤ 75°C.
A pharmaceutical composition for use in treating inflammatory, autoimmune or cardiovascular diseases, wherein said pharmaceutical composition comprises at least one eotaxin-2 antibody or a fragment thereof which retains the binding activity of the antibody to eotaxin-2 and a pharmaceutically acceptable carrier or excipient, and, wherein said antibody is a monoclonal antibody selected from the group consisting of: a. a monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702; b. a monoclonal antibody comprising a heavy chain encoded by a nucleic acid having at least 90% homology with SEQ ID NO: 1 and a light chain encoded by a nucleic acid having at least 90% homology with SEQ ID NO: 2; c. a monoclonal antibody comprising a heavy chain encoded by a nucleic acid having at least 90% homology with the nucleic acid encoding the heavy chain of the monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702, and a light chain encoded by a nucleic acid having at least 90% homology with the nucleic acid encoding the light chain of the monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702; and d. any fragment of the antibodies of a-c which retains the binding activity of the antibody to eotaxin-2. a. a monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702; b. a monoclonal antibody comprising a heavy chain encoded by a nucleic acid having at least 90% homology with SEQ ID NO: 1 and a light chain encoded by a nucleic acid having at least 90% homology with SEQ ID NO: 2; c. a monoclonal antibody comprising a heavy chain encoded by a nucleic acid having at least 90% homology with the nucleic acid encoding the heavy chain of the monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702, and a light chain encoded by a nucleic acid having at least 90% homology with the nucleic acid encoding the light chain of the monoclonal antibody secreted by hybridoma D8 having the ECACC Accession No. D809081702; and d. any fragment of the antibodies of a-c which retains the binding activity of the antibody to eotaxin-2.
A computer-implemented method, comprising: instantiating a plurality of model objects on a plurality of model servers (210, 212), wherein each of the plurality of model objects includes a model of a plant or process being controlled, and wherein at least one of the models contains proprietary information; requesting information from the plurality of model objects via a communication network; receiving the information from the plurality of model objects via the communication network, wherein the information received from the plurality of model objects does not include proprietary information; generating an approximation of at least one of the plurality of the models of the plant or process being controlled based on the received information, wherein the approximation is relevant to generating control commands; generating control commands based at least in part on the approximation and the information received from the plurality of model objects; transmitting the control commands to at least one of the plurality of model objects via the communication network; and controlling an industrial automation component in the plant or process based on the control commands. instantiating a plurality of model objects on a plurality of model servers (210, 212), wherein each of the plurality of model objects includes a model of a plant or process being controlled, and wherein at least one of the models contains proprietary information; requesting information from the plurality of model objects via a communication network; receiving the information from the plurality of model objects via the communication network, wherein the information received from the plurality of model objects does not include proprietary information; generating an approximation of at least one of the plurality of the models of the plant or process being controlled based on the received information, wherein the approximation is relevant to generating control commands; generating control commands based at least in part on the approximation and the information received from the plurality of model objects; transmitting the control commands to at least one of the plurality of model objects via the communication network; and controlling an industrial automation component in the plant or process based on the control commands.
A method of diagnosing or monitoring a cancer disease characterized by increased expression of a tumor-associated antigen compared to the state in a healthy individual, which method comprises detecting or determining the amount (i) of a nucleic acid which codes for the tumor-associated antigen, and/or (ii) of the tumor-associated antigen or of a part thereof, in a biological sample, wherein said part comprises at least 6 consecutive amino acids of the tumor-associated antigen, with said tumor-associated antigen having a sequence encoded by a nucleic acid which is selected from the group consisting of: (a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 25 and 28, and (b) a nucleic acid which is at least 95% identical to the nucleic acid of (a), in which the cancer is an ovarian tumor, a breast cancer, a melanoma, or a mammary carcinoma. (i) of a nucleic acid which codes for the tumor-associated antigen, and/or (ii) of the tumor-associated antigen or of a part thereof, (a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 25 and 28, and (b) a nucleic acid which is at least 95% identical to the nucleic acid of (a),
Elastic link provided with a progressive resistivity to stretching and comprising at least two elastic strands (1, 2, 3, 4...), each of said strands being fastened by means of the opposite ends thereof, at two mutually distant points (6-7; 6-8; 6-9; 6-10), of a strap, characterised in that the elastic strands (1, 2, 3, 4,...) are fastened, on one hand, at a common fastening point of the strap and, on the other, at mutually spaced points (7, 8, 9, 10) at different distances from the common fastening point on an intermediate portion of the strap between end portions (5b, 5c) thereof.
A rectangular secondary battery comprising: an electrode body including a positive electrode plate and a negative electrode plate; a rectangular battery case having an opening and housing the electrode body; a sealing plate sealing the opening; a current collector (16, 17) extending on an end side of the sealing plate in a longitudinal direction thereof and joined, by ultrasonic welding, to an end of the positive electrode plate or the negative electrode plate; and an external terminal (14, 15) provided outside the sealing plate and connected to the current collector (16, 17), wherein the sealing plate has a gas discharge valve ruptured when an internal gas pressure of the battery case has reached a predetermined value or greater, and a thin portion (23, 24) formed between the external terminal (14, 15) and the gas discharge valve and formed thicker than the gas discharge valve; wherein, when the smallest distance between any two points of the gas discharge valve and the external terminal (14, 15) is H and the distance between the gas discharge valve and the thin portion (23, 24) is h, h/H ≥ 0.2 is satisfied. an electrode body including a positive electrode plate and a negative electrode plate; a rectangular battery case having an opening and housing the electrode body; a sealing plate sealing the opening; a current collector (16, 17) extending on an end side of the sealing plate in a longitudinal direction thereof and joined, by ultrasonic welding, to an end of the positive electrode plate or the negative electrode plate; and an external terminal (14, 15) provided outside the sealing plate and connected to the current collector (16, 17), wherein the sealing plate has a gas discharge valve ruptured when an internal gas pressure of the battery case has reached a predetermined value or greater, and a thin portion (23, 24) formed between the external terminal (14, 15) and the gas discharge valve and formed thicker than the gas discharge valve; a gas discharge valve ruptured when an internal gas pressure of the battery case has reached a predetermined value or greater, and a thin portion (23, 24) formed between the external terminal (14, 15) and the gas discharge valve and formed thicker than the gas discharge valve; wherein, when the smallest distance between any two points of the gas discharge valve and the external terminal (14, 15) is H and the distance between the gas discharge valve and the thin portion (23, 24) is h, h/H ≥ 0.2 is satisfied.
Device for connecting a structural element, in particular made of a fibre-reinforced plastic composite material, to a holding element at a spacing from one another by means of a connecting screw, the device comprising a distance compensation element which has a longitudinal bore for the passage of the connecting screw, and comprising an entraining element which is arranged in the longitudinal bore and can be connected to the connecting screw by means of a friction fit, such that the distance compensation element can be transferred into a stop position which bridges the spacing between the structural element and the holding element by the connecting screw being screwed in, the distance compensation element being connected by a threaded connection to an insert part which has a fastening portion for gluing to the structural element, which portion can be arranged within the structural element, characterised in that the insert part has two fastening flanges on the fastening portion, which flanges are arranged spaced apart from one another and are for gluing the insert part to the structural element.
Split mould specially designed to be used in a moulding apparatus for moulding at least one undercut pot including a bottom wall as well as a side wall closed onto itself and connected to the bottom wall, the side wall and the bottom wall including an internal surface defining a pot interior as well as an external surface opposite to the internal surface, the pot further comprising an opening giving access to the pot interior, said opening being suitable for being covered by a top fastener to isolate the pot interior, the opening extending along a horizontal plane and defining a vertical direction, perpendicular to the horizontal plane, passing through a barycentre of the opening, and oriented from the bottom wall towards the opening, the external surface of the side wall of the pot having a non-symmetrical undercut shape revolving about the vertical direction, said external surface having at least one vertical mould release plane such that an undercut value of the pot at respective lateral ends of the pot, of maximum lateral spacing of the external surface with respect to the vertical mould release plane, is less than a maximum undercut value of the pot over the circumference of the external surface of the pot, the split mould including a first sub-mould and a second sub-mould, said sub-moulds being suitable for being moved along a mould release direction between a closed position wherein the first sub-mould and the second sub-mould are in mutual contact and an open position wherein said sub-moulds are distant from one another, said first sub-mould and second sub-mould forming at least one internal cavity in the closed position of the mould, said at least one cavity being defined by an internal cavity surface comprising an internal surface of the first sub-mould and an internal surface of the second sub-mould, the cavity being open at the location of a top surface of the split mould, by a top opening extending along a horizontal plane comprising the mould release direction, the top opening defining a vertical direction of the cavity, perpendicular to the horizontal plane, passing via a barycentre of said top opening, and oriented from a cavity bottom towards the top opening, the split mould being characterised in that the internal cavity surface in the closed position has a non-symmetrical undercut shape revolving about the vertical direction, said internal surface having at least one vertical mould release plane comprising the vertical direction as well as the mould release direction and being such that an undercut value of the mould at respective lateral ends of the internal cavity of the mould, of maximum lateral spacing of the internal surface with respect to the vertical mould release plane, is less than a maximum undercut value of the mould over the circumference of the internal surface of the internal cavity.