A laboratory instrument, comprising: a clean chamber (5, 105), comprising a housing adapted to house a 3D printer or bioprinter, wherein the housing comprises a metal frame; an air supply unit (30, 130) comprising a blower or fan and being adapted to bring filtered air into the housing from outside the housing; and one or more vents disposed within the housing; said vents being adapted to let air exit the housing; a plurality of windows and doors disposed within the housing that provide viewing or access to portions of the 3D printer or bioprinter; a sealing system around the doors and windows of the housing; wherein together the air supply unit (30, 130), one or more vents, and sealing system are configured to provide positive pressure and an essentially clean environment inside the housing; wherein the clean chamber (5, 105) is capable of maintaining positive pressure inside by way of the air supply unit (30, 130); and a 3D printer comprising: a 3D printbed; one or more fluid sources adapted for 3D printing disposed above the printbed; characterized in that said air supply unit (30, 130) comprises a high-efficiency air filter; said filter being adapted to filter out at least 95% of particles of 0.30 microns or greater in ambient air surrounding the housing; and wherein the air supply unit (30, 130) is disposed within the housing and at the top of the housing, and the one or more vents are disposed at the sides or the bottom of the housing, and wherein the housing has a volume that is less than 1m 3; and wherein the 3D printer is disposed within the housing such that the 3D printbed is disposed between the air supply unit (30, 130) and the one or more vents. a clean chamber (5, 105), comprising a housing adapted to house a 3D printer or bioprinter, wherein the housing comprises a metal frame; an air supply unit (30, 130) comprising a blower or fan and being adapted to bring filtered air into the housing from outside the housing; and one or more vents disposed within the housing; said vents being adapted to let air exit the housing; a plurality of windows and doors disposed within the housing that provide viewing or access to portions of the 3D printer or bioprinter; a sealing system around the doors and windows of the housing; wherein together the air supply unit (30, 130), one or more vents, and sealing system are configured to provide positive pressure and an essentially clean environment inside the housing; a housing adapted to house a 3D printer or bioprinter, wherein the housing comprises a metal frame; an air supply unit (30, 130) comprising a blower or fan and being adapted to bring filtered air into the housing from outside the housing; and one or more vents disposed within the housing; said vents being adapted to let air exit the housing; a plurality of windows and doors disposed within the housing that provide viewing or access to portions of the 3D printer or bioprinter; a sealing system around the doors and windows of the housing; wherein together the air supply unit (30, 130), one or more vents, and sealing system are configured to provide positive pressure and an essentially clean environment inside the housing; wherein the clean chamber (5, 105) is capable of maintaining positive pressure inside by way of the air supply unit (30, 130); and a 3D printer comprising: a 3D printbed; one or more fluid sources adapted for 3D printing disposed above the printbed; a 3D printbed; one or more fluid sources adapted for 3D printing disposed above the printbed; characterized in that said air supply unit (30, 130) comprises a high-efficiency air filter; said filter being adapted to filter out at least 95% of particles of 0.30 microns or greater in ambient air surrounding the housing; and wherein the air supply unit (30, 130) is disposed within the housing and at the top of the housing, and the one or more vents are disposed at the sides or the bottom of the housing, and wherein the housing has a volume that is less than 1m 3; and wherein the 3D printer is disposed within the housing such that the 3D printbed is disposed between the air supply unit (30, 130) and the one or more vents.