A heat dissipation device configured for a working fluid to flow therethrough, said heat dissipation device comprising: a base having at least one internal channel configured for the working fluid to flow therethrough, wherein the base has a first side surface, a second side surface, and at least one assembling slot, the second side surface faces away from the first side surface, and the at least one assembling slot is located at the second side surface; at least one heat dissipation fin having an extension channel and an inlet and an outlet in fluid communication with the extension channel, wherein the at least one heat dissipation fin is inserted into one side of the base, and the extension channel is in fluid communication with the at least one internal channel and the outlet through the inlet; and at least one fluid replenisher in fluid communication with the at least one internal channel, characterized in that the at least one internal channel has an inlet part (Si), an outlet part (So), a first channel part, a second channel part, a third channel part, a first connecting part, and a second connecting part, the first channel part and the third channel part are respectively in fluid communication with the inlet part and the outlet part, and two opposite ends of the second channel part are respectively in fluid communication with the first channel part and the third channel part via the first connecting part and the second connecting part, the second channel part is located closer to the first side surface than the first channel part, and the first channel part is located closer to the first side surface than the third channel part, and the at least one fluid replenisher is in fluid communication with the first channel part. a base having at least one internal channel configured for the working fluid to flow therethrough, wherein the base has a first side surface, a second side surface, and at least one assembling slot, the second side surface faces away from the first side surface, and the at least one assembling slot is located at the second side surface; at least one heat dissipation fin having an extension channel and an inlet and an outlet in fluid communication with the extension channel, wherein the at least one heat dissipation fin is inserted into one side of the base, and the extension channel is in fluid communication with the at least one internal channel and the outlet through the inlet; and at least one fluid replenisher in fluid communication with the at least one internal channel, characterized in that the at least one internal channel has an inlet part (Si), an outlet part (So), a first channel part, a second channel part, a third channel part, a first connecting part, and a second connecting part, the first channel part and the third channel part are respectively in fluid communication with the inlet part and the outlet part, and two opposite ends of the second channel part are respectively in fluid communication with the first channel part and the third channel part via the first connecting part and the second connecting part, the second channel part is located closer to the first side surface than the first channel part, and the first channel part is located closer to the first side surface than the third channel part, and the at least one fluid replenisher is in fluid communication with the first channel part.