A bone fragment and osteomedullary tissue harvesting system for harvesting bone fragments and osteomedullary tissue, wherein the bone fragment and osteomedullary tissue harvesting system comprises: a harvesting device comprising a needle portion having a bore formed therein and wherein a tip portion extends from an end of the needle portion; wherein the tip portion comprises a first tip region, a second tip region and a third tip region, wherein the first tip region has a first cutting element, a second cutting element and an open region (148 a, b) between the first cutting element and the second cutting element, wherein the first tip region has an outer diameter, wherein the second tip region has an outer diameter that is less than the outer diameter of the first tip region, wherein the open region (148 a, b) is in communication with the second tip region, wherein the second tip region has at least one aperture formed therein, wherein the at least one aperture is in communication with the bore, wherein the third tip region has an outer diameter that is not smaller than the outer diameter of the first tip region, wherein the second tip region is intermediate the first tip region and the third tip region, and wherein the third tip region is proximate the needle portion, characterized in that the harvesting device consists of a handle portion and a needle portion, wherein the needle portion is attached to and oriented at an angle of between 60 degrees and 90 degrees with respect to the handle portion and wherein the third tip region is configured to contact tissue adjacent thereto and form a seal between the third tip region and the adjacent tissue so that it is substantially prevented that a vacuum be pulled between the third tip region and tissue proximate the at least one aperture. wherein the bone fragment and osteomedullary tissue harvesting system comprises: a harvesting device comprising a needle portion having a bore formed therein and wherein a tip portion extends from an end of the needle portion; wherein the tip portion comprises a first tip region, a second tip region and a third tip region, wherein the first tip region has a first cutting element, a second cutting element and an open region (148 a, b) between the first cutting element and the second cutting element, wherein the first tip region has an outer diameter, wherein the second tip region has an outer diameter that is less than the outer diameter of the first tip region, wherein the open region (148 a, b) is in communication with the second tip region, wherein the second tip region has at least one aperture formed therein, wherein the at least one aperture is in communication with the bore, wherein the third tip region has an outer diameter that is not smaller than the outer diameter of the first tip region, wherein the second tip region is intermediate the first tip region and the third tip region, and wherein the third tip region is proximate the needle portion, characterized in that the harvesting device consists of a handle portion and a needle portion, wherein the needle portion is attached to and oriented at an angle of between 60 degrees and 90 degrees with respect to the handle portion and wherein the third tip region is configured to contact tissue adjacent thereto and form a seal between the third tip region and the adjacent tissue so that it is substantially prevented that a vacuum be pulled between the third tip region and tissue proximate the at least one aperture.