mhurhangee/ep-ind-claims huggingface dataset:
An IL-2 variant for use in a method of treating an inflammatory disorder selected from the group consisting of asthma, diabetes, arthritis, allergy, organ graft rejection, graft-versus-host disease, inflammation, autoimmune disease, paraneoplastic autoimmune diseases, cartilage inflammation, fibrotic disease, bone degradation, rheumatoid arthritis, juvenile arthritis, juvenile rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, polyarticular juvenile rheumatoid arthritis, systemic onset juvenile rheumatoid arthritis, juvenile ankylosing spondylitis, juvenile enteropathic arthritis, juvenile reactive arthritis, juvenile Reiter's Syndrome, juvenile SEA Syndrome (Seronegativity, Enthesopathy, Arthropathy Syndrome), juvenile dermatomyositis, juvenile psoriatic arthritis, juvenile scleroderma, juvenile systemic lupus erythematosus, juvenile vasculitis, pauciarticular rheumatoid arthritis, polyarticular rheumatoid arthritis, systemic onset rheumatoid arthritis, ankylosing spondylitis, enteropathic arthritis, reactive arthritis, Reiter's Syndrome, SEA Syndrome (Seronegativity, Enthesopathy, Arthropathy Syndrome), dermatomyositis, psoriatic arthritis, scleroderma, vasculitis, myositis, polymyositis, osteoarthritis, polyarteritis nodosa, Wegener's granulomatosis, arteritis, polymyalgia rheumatica, sarcoidosis, scleroderma, sclerosis, primary biliary sclerosis, sclerosing cholangitis, Sjogren's syndrome, psoriasis, plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis, dermatitis, atopic dermatitis, atherosclerosis, lupus, Still's disease, Systemic Lupus Erythematosus, myasthenia gravis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, celiac disease, multiple sclerosis, COPD, Guillain-Barre disease, Type I diabetes mellitus, thyroiditis (e.g., Graves' disease), Addison's disease, Raynaud's phenomenon, autoimmune hepatitis and transplantation rejection in a subject, wherein said IL-2 variant (a) comprises a sequence of amino acids at least 80% identical to SEQ ID NO:1; (b) stimulates STAT5 phosphorylation in FOXP3-positive regulatory T cells; and (c) has a reduced ability compared to the polypeptide set forth as SEQ ID NO:1 to induce phosphorylation of STAT5 in FOXP3-negative T cells, and wherein the IL-2 variant comprises a mutation in the polypeptide sequence set forth in SEQ ID NO:1 at a position selected from the group consisting of amino acid 30, amino acid 31, amino acid 35, amino acid 69, amino acid 74 and amino acid 88 and wherein the mutation at position 30 is N30S, the mutation at position 31 is Y31H, the mutation at position 35 is K35R, the mutation at position 69 is V69A, the mutation at position 74 is Q74P and the mutation at position 88 is N88D. (a) comprises a sequence of amino acids at least 80% identical to SEQ ID NO:1; (b) stimulates STAT5 phosphorylation in FOXP3-positive regulatory T cells; and (c) has a reduced ability compared to the polypeptide set forth as SEQ ID NO:1 to induce phosphorylation of STAT5 in FOXP3-negative T cells, and
Laminatable, multi-stage curing ink, comprising compounds for forming at least one organic matrix, selected from acrylate monomers and/or methacrylate monomers and/or vinyl acrylate monomers, or acrylate oligomers and/or methacrylate oligomers and/or vinyl acrylate oligomers, and mixtures thereof, which at least one organic matrix is cured by radical polymerisation and which curing can be initiated by radiation, and comprising alkoxysilanes in an amount of 10 to 60 wt.%, more preferably 20 to 50 wt.%, based on the entire formulation, for forming at least one inorganic matrix which is cured by non-radical polymerisation and which curing can be initiated thermally, characterised in that the ink, in addition to a dispersing aid, also contains a structure-reinforcing polymer selected from polyester, polyurethane and polyamide having a number-average molar mass (Mn) of greater than 3,000 g/mol, preferably greater than 10,000 g/mol and particularly preferably greater than 30,000 g/mol, and the viscosity of the ink at 50°C is in the range of 6 to 15 mPa·s, particularly preferably in the range of 9 to 11 mPa·s, measured by means of a Brookfield rheometer using a UL adapter at a rotation speed of 50 revolutions per minute.
A collecting assembly, comprising: a condensing device including an inlet, an outlet and a spiral-shaped conduit extending between the inlet and the outlet; characterised in that the collecting assembly further comprises: a receptacle for collecting emissions from the condensing device, the receptacle having a side wall and a base, wherein the inner surface of the base defines a cone shape.
A direct-current voltage conversion circuit comprising: a switching circuit having a plurality of switching elements; and a controller that is configured to control operations of the plurality of switching elements, wherein the controller is configured to: execute asymmetric PWM control for controlling a duty ratio by varying a pulse width of two switching elements included in the plurality of switching elements and connected in series and phase shift control for controlling the duty ratio by varying an amount of phase shift of two switching elements included in the plurality of switching elements and not connected in series, characterised by perform the phase shift control when the duty ratio is lower than a predetermined ratio, perform the asymmetric PWM control when the duty ratio is higher than or equal to the predetermined ratio; and perform switching between the phase shift control and the asymmetric PWM control by changing duty ratios discontinuously such that step-down ratios immediately before and after the switching change within a predetermined range which is ±5%. execute asymmetric PWM control for controlling a duty ratio by varying a pulse width of two switching elements included in the plurality of switching elements and connected in series and phase shift control for controlling the duty ratio by varying an amount of phase shift of two switching elements included in the plurality of switching elements and not connected in series, characterised by perform the phase shift control when the duty ratio is lower than a predetermined ratio, perform the asymmetric PWM control when the duty ratio is higher than or equal to the predetermined ratio; and perform switching between the phase shift control and the asymmetric PWM control by changing duty ratios discontinuously such that step-down ratios immediately before and after the switching change within a predetermined range which is ±5%.
A communication system configured to perform communication by flooding using concurrent transmission among a plurality of communication nodes, the plurality of communication nodes including a transmission node configured to generate and transmit a packet, a plurality of relay nodes (120a-120f) configured to relay the packet, and a destination node as a destination of the packet, wherein: the transmission node is configured to generate and transmit the packet including predetermined transmission data, timing information corresponding to a transmission timing of the packet, a first error detection code, and a second error detection code, the first error detection code being generated for at least the transmission data, and the second error detection code being generated for at least the transmission data, the timing information and the first error detection code; each of the plurality of relay nodes (120a-120f) is configured to receive the packet and to perform error detection based on the second error detection code, the relay node being further configured to discard the packet if an error is detected, and, if no error is detected, to change the timing information, to update the second error detection code, and to reconstruct and transmit the packet; and the destination node is configured to receive the packet from one of the transmission node and the relay nodes, and to perform error detection based on at least the first error detection code; wherein the second error detection code is generated for all data except for the second error detection code in the packet, and the first error detection code is generated for all data except for the timing information, the first error detection code, and the second error detection code in the packet. the transmission node is configured to generate and transmit the packet including predetermined transmission data, timing information corresponding to a transmission timing of the packet, a first error detection code, and a second error detection code, the first error detection code being generated for at least the transmission data, and the second error detection code being generated for at least the transmission data, the timing information and the first error detection code; each of the plurality of relay nodes (120a-120f) is configured to receive the packet and to perform error detection based on the second error detection code, the relay node being further configured to discard the packet if an error is detected, and, if no error is detected, to change the timing information, to update the second error detection code, and to reconstruct and transmit the packet; and the destination node is configured to receive the packet from one of the transmission node and the relay nodes, and to perform error detection based on at least the first error detection code; wherein the second error detection code is generated for all data except for the second error detection code in the packet, and the first error detection code is generated for all data except for the timing information, the first error detection code, and the second error detection code in the packet.
An electrosurgical system, comprising: an electrosurgical device having an ablation probe including an antenna assembly configured to direct microwave energy to tissue, the probe including a shaft; a coolant chamber configured to circulate coolant fluid around at least a portion of the antenna assembly; and bending detection circuitry having at least one tube-shaped bending detection member positioned on the probe for detecting bending of the probe, wherein the at least one bending detection member includes at least one actuator, wherein the at least one actuator is a piezoelectric bending actuator, wherein the piezoelectric bending actuator comprises at least two piezoelectric sensor layers including an inner layer (206, 206') and an outer layer (204, 204'), and wherein the detection circuitry is configured to receive an output from the bending detection member and process the output to determine if a degree of bending exceeds a predetermined bending threshold representing excessive bending approaching a bending load on the shaft which may cause a sudden failure to occur. an electrosurgical device having an ablation probe including an antenna assembly configured to direct microwave energy to tissue, the probe including a shaft; a coolant chamber configured to circulate coolant fluid around at least a portion of the antenna assembly; and bending detection circuitry having at least one tube-shaped bending detection member positioned on the probe for detecting bending of the probe, wherein the at least one bending detection member includes at least one actuator, wherein the at least one actuator is a piezoelectric bending actuator, wherein the piezoelectric bending actuator comprises at least two piezoelectric sensor layers including an inner layer (206, 206') and an outer layer (204, 204'), and wherein the detection circuitry is configured to receive an output from the bending detection member and process the output to determine if a degree of bending exceeds a predetermined bending threshold representing excessive bending approaching a bending load on the shaft which may cause a sudden failure to occur.
A method of reducing interference from leukocytes in an analyte immunoassay, comprising: contacting a biological sample containing leukocytes with magnetic sacrificial beads opsonized to said leukocytes under conditions sufficient to bind at least a portion of said leukocytes in the biological sample to the magnetic sacrificial beads; and magnetically retaining the magnetic sacrificial beads substantially out of contact from an electrochemical immunosensor attached to an immobilized antibody; wherein the magnetic sacrificial beads are present in an amount in excess of the leukocytes in the biological sample sufficient to substantially engage any leukocytes present in the sample. contacting a biological sample containing leukocytes with magnetic sacrificial beads opsonized to said leukocytes under conditions sufficient to bind at least a portion of said leukocytes in the biological sample to the magnetic sacrificial beads; and magnetically retaining the magnetic sacrificial beads substantially out of contact from an electrochemical immunosensor attached to an immobilized antibody; wherein the magnetic sacrificial beads are present in an amount in excess of the leukocytes in the biological sample sufficient to substantially engage any leukocytes present in the sample.
A polyester composition having improved reheat, comprising: a polyester polymer; and titanium carbide particles, having a median particle size from 0.005 μm to 100 μm, dispersed in the polyester polymer in an amount from 0.5 ppm to 1000 ppm, with respect to the total weight of the polyester composition. a polyester polymer; and titanium carbide particles, having a median particle size from 0.005 μm to 100 μm, dispersed in the polyester polymer in an amount from 0.5 ppm to 1000 ppm, with respect to the total weight of the polyester composition.
An interactive system, the interactive system comprising: a remote controller (1000, 8100, 8300); a camera configured to capture an operating frame; and a processor configured to receive the operating frame, the interactive system being characterized in that: the remote controller (1000, 8100, 8300) is configured to be held by a user to be moved in a three-dimensional space; the camera is arranged on the remote controller (1000, 8100, 8300) to be movable with the remote controller (1000, 8100, 8300) in the three-dimensional space and configured to capture the operating frame comprising a user image of the user holding the remote controller (1000, 8100, 8300) and a background image (1521, 1522) of a background behind the user; and the processor being arranged on the remote controller (1000, 8100, 8300) and further configured to analyze the operating frame to respectively identify a user image region belonging to the user image in the operating frame and a background image region belonging to the background image (1521, 1522) in the operating frame, and to generate a movement information of the remote controller (1000, 8100, 8300) moving in the three-dimensional space according to a variation of imaging positions of both the user image region and the background image region. a remote controller (1000, 8100, 8300); a camera configured to capture an operating frame; and a processor configured to receive the operating frame, the remote controller (1000, 8100, 8300) is configured to be held by a user to be moved in a three-dimensional space; the camera is arranged on the remote controller (1000, 8100, 8300) to be movable with the remote controller (1000, 8100, 8300) in the three-dimensional space and configured to capture the operating frame comprising a user image of the user holding the remote controller (1000, 8100, 8300) and a background image (1521, 1522) of a background behind the user; and the processor being arranged on the remote controller (1000, 8100, 8300) and further configured to analyze the operating frame to respectively identify a user image region belonging to the user image in the operating frame and a background image region belonging to the background image (1521, 1522) in the operating frame, and to generate a movement information of the remote controller (1000, 8100, 8300) moving in the three-dimensional space according to a variation of imaging positions of both the user image region and the background image region.
An energy storage device comprising a positive electrode and a negative electrode that are insulated from each other with a separator interposed therebetween, and a non-aqueous electrolyte, wherein the separator includes a base material layer and a coating layer that is disposed on at least one surface of the base material layer, and the separator has an air permeability of the base material layer of 25 s/100 ml or greater and 250 s/100 ml or less, a porosity of the base material layer in the range of 45% or greater and 80% or less, an air permeability of an interface between the base material layer and the coating layer of 1 s/100 ml or greater and 15 s/100 ml or less, and an air permeability of the coating layer of 1 s/100 ml or greater and 15 s/100 ml or less, wherein as the base material layer 431, a resin porous film having polymer fibers, natural fibers, hydrocarbon fibers, glass fibers or ceramic fibers that are woven or non-woven is used.
A method comprising: introducing (i) an oxidant, and (ii) a liquid phase comprising a substrate selected from the group consisting of a dicarboxylic acid oxidation precursor, a benzoic acid oxidation precursor, a 2-methylbenzoic acid oxidation precursor, a 3-methylbenzoic acid oxidation precursor, a 4-methylbenzoic acid oxidation precursor, and a phthalic anhydride oxidation precursor into a high shear device comprising at least one rotor and at least one complementarily-shaped stator, said rotor and stator being toothed; forming a dispersion under high shear in the high shear device, said dispersion comprising gas bubbles of the oxidant dispersed in the liquid phase, wherein said bubbles have a mean diameter of less than 1.5 micron; and contacting said dispersion with an oxidation catalyst to produce a product stream, said oxidation catalyst being present as a catalytic surface in the high shear device, wherein said product stream comprises a substance selected from the group consisting of dicarboxylic acid, benzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 4-methylbenzoic acid, and phthalic anhydride. introducing (i) an oxidant, and (ii) a liquid phase comprising a substrate selected from the group consisting of a dicarboxylic acid oxidation precursor, a benzoic acid oxidation precursor, a 2-methylbenzoic acid oxidation precursor, a 3-methylbenzoic acid oxidation precursor, a 4-methylbenzoic acid oxidation precursor, and a phthalic anhydride oxidation precursor into a high shear device comprising at least one rotor and at least one complementarily-shaped stator, said rotor and stator being toothed; forming a dispersion under high shear in the high shear device, said dispersion comprising gas bubbles of the oxidant dispersed in the liquid phase, wherein said bubbles have a mean diameter of less than 1.5 micron; and contacting said dispersion with an oxidation catalyst to produce a product stream, said oxidation catalyst being present as a catalytic surface in the high shear device, wherein said product stream comprises a substance selected from the group consisting of dicarboxylic acid, benzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 4-methylbenzoic acid, and phthalic anhydride.
A die for forming a molding which serves to form a resin molding integrally adhered to a peripheral edge portion of a glass plate and at the same time, adhere a metal molding to the resin molding, the die for forming a molding comprising: a molding die comprising an upper die forming an upper surface of the resin molding that is formed on the peripheral edge portion of the glass plate, and a lower die cooperating with the upper die to support the glass plate, the lower die forming a lower surface of the resin molding, the lower die having a concave surface including a contact surface that comes into contact with the metal molding, and a plurality of aperture portions formed on the contact surface, characterized in that the die further comprises: a non-magnetic cylindrical intervening member contacted with an inner surface of each of the aperture portions; a molding-fixing member disposed inside of the intervening member, the molding-fixing member comprising a crown portion that retains the metal molding by a magnetic force, and a flange portion disposed on a lower side of the crown portion, and a magnetic force generation device that applies the magnetic force to the molding-fixing member, wherein the flange portion of the molding-fixing member has an outer diameter larger than an inner diameter of each of the aperture portions such that an upper end of the crown portion of the molding-fixing member is prevented from projecting beyond the concave surface of the lower die due to thermal expansion of the magnetic force generation device. a molding die comprising an upper die forming an upper surface of the resin molding that is formed on the peripheral edge portion of the glass plate, and a lower die cooperating with the upper die to support the glass plate, the lower die forming a lower surface of the resin molding, the lower die having a concave surface including a contact surface that comes into contact with the metal molding, and a plurality of aperture portions formed on the contact surface, characterized in that the die further comprises: a non-magnetic cylindrical intervening member contacted with an inner surface of each of the aperture portions; a molding-fixing member disposed inside of the intervening member, the molding-fixing member comprising a crown portion that retains the metal molding by a magnetic force, and a flange portion disposed on a lower side of the crown portion, and a magnetic force generation device that applies the magnetic force to the molding-fixing member, wherein the flange portion of the molding-fixing member has an outer diameter larger than an inner diameter of each of the aperture portions such that an upper end of the crown portion of the molding-fixing member is prevented from projecting beyond the concave surface of the lower die due to thermal expansion of the magnetic force generation device.
An injection device comprising, a dose setting and injecting assembly comprising, i. two sets of dose setting and injecting components configured so that each set of components can operate independently during dose setting and both sets of components can operate simultaneously during dose injecting, where each set of components comprises a spring, a plunger, a drive shaft and a gear; ii. a single trigger connected to one or more of the dose setting and injecting components characterized in that when the trigger is activated the spring provides energy to drive the plunger, and that the trigger comprises an assembly that is in direct connection with both gears when the trigger is in a dose setting position and is disconnected from both gears when the trigger is activated to a dose injection position. i. two sets of dose setting and injecting components configured so that each set of components can operate independently during dose setting and both sets of components can operate simultaneously during dose injecting, where each set of components comprises a spring, a plunger, a drive shaft and a gear; ii. a single trigger connected to one or more of the dose setting and injecting components characterized in that when the trigger is activated the spring provides energy to drive the plunger, and that the trigger comprises an assembly that is in direct connection with both gears when the trigger is in a dose setting position and is disconnected from both gears when the trigger is activated to a dose injection position.