A dry powder inhaler with a distal end and a proximal end comprising: at least one inlet and at least one outlet, wherein a communication between said at least one inlet and said at least one outlet at least comprises a dosage communication in a dose administering position, wherein the at least one outlet is arranged at the proximal end of the dry powder drug inhaler, while the at least one inlet is arranged at a zone in the opposite distal end of the dry powder inhaler, the at least one outlet is arranged centrally, along a longitudinal axis of the dry powder inhaler; a first medicament reservoir for housing a dry powder first medicament; a second medicament reservoir for housing a dry powder second medicament; a dosage mechanism (104, 108) for withdrawing an inhaler metered dose of the dry powder in the first and second medicament reservoirs (109, 110) in a dose collecting position from the reservoirs (109, 110) into said dosage communication in the dose administering position; wherein the dosage mechanism (104, 108) further comprises a dose disc with at least one opening per reservoir (109, 110), wherein the dose disc may be rotated between the dose collecting position, wherein the openings are positioned in the reservoirs (109, 110), and the dose administering position, wherein the openings communicate with said dosage communication; wherein the dose disc is configured such that, in the dose administering position, a first set of two openings are superimposed the communications, while a second set of two openings are positioned in the medicament reservoirs (109, 110), respectively, wherein the first and second set of two openings are comprised in the openings of the dose disc; further comprising one dosage communication per reservoir (109, 110), said dosage communications extending from one inlet each to a mixing and deaggregation chamber; further comprising an inhalation chimney interconnecting the chamber and the at least one outlet; wherein the inhalation chimney is directed upwardly towards the proximal end, characterised in that: the dosage communications are S-shaped between the corresponding inlet and the chamber. at least one inlet and at least one outlet, wherein a communication between said at least one inlet and said at least one outlet at least comprises a dosage communication in a dose administering position, wherein the at least one outlet is arranged at the proximal end of the dry powder drug inhaler, while the at least one inlet is arranged at a zone in the opposite distal end of the dry powder inhaler, the at least one outlet is arranged centrally, along a longitudinal axis of the dry powder inhaler; a first medicament reservoir for housing a dry powder first medicament; a second medicament reservoir for housing a dry powder second medicament; a dosage mechanism (104, 108) for withdrawing an inhaler metered dose of the dry powder in the first and second medicament reservoirs (109, 110) in a dose collecting position from the reservoirs (109, 110) into said dosage communication in the dose administering position; wherein the dosage mechanism (104, 108) further comprises a dose disc with at least one opening per reservoir (109, 110), wherein the dose disc may be rotated between the dose collecting position, wherein the openings are positioned in the reservoirs (109, 110), and the dose administering position, wherein the openings communicate with said dosage communication; wherein the dose disc is configured such that, in the dose administering position, a first set of two openings are superimposed the communications, while a second set of two openings are positioned in the medicament reservoirs (109, 110), respectively, wherein the first and second set of two openings are comprised in the openings of the dose disc; further comprising one dosage communication per reservoir (109, 110), said dosage communications extending from one inlet each to a mixing and deaggregation chamber; further comprising an inhalation chimney interconnecting the chamber and the at least one outlet; wherein the inhalation chimney is directed upwardly towards the proximal end, characterised in that: the dosage communications are S-shaped between the corresponding inlet and the chamber.