A method for hydroprocessing a biocomponent feedstock, comprising: exposing a biocomponent feedstock comprising at least a bio-derived fraction to a bulk mixed metal catalyst in the presence of hydrogen under effective deoxygenation conditions, the bulk mixed metal catalyst comprising at least one Group VI metal and at least one Group VIII metal; wherein the bulk mixed metal catalyst is comprised of at least 90 wt% Mo, W, and Ni, and this portion of the bulk mixed metal catalyst has the formula: (Ni) b (Mo) c d Oz wherein the molar ratio of b:(c+d) is 0.5:1 to 3:1; the molar ratio of c:d is preferably > 0.01:1; the molar ratio of Mo and W is 2:3 to 3:2; and z=[2b+6(c+d)]/2; wherein the effective deoxygenation conditions include a hydrogen partial pressure of from 200 psig (1.4 MPag) to 2000 psig (13.8 MPag), a reaction temperature of from 400 O F to 500 O F (204 O C to 260 O C), a liquid hourly space velocity of from 0.1 hr -1 to 10 hr -1, and a hydrogen treat gas rate from 500 scf/B (84 Nm 3 /m 3) to 10,000 scf/B (1685 Nm 3 /m 3); forming a deoxygenated effluent wherein at least 75 wt% of the oxygen has been removed from the biocomponent feedstock compounds; and exposing at least a portion of the deoxygenated effluent to a hydrodesulfurization catalyst under effective hydrodesulfurization conditions to produce a deoxygenated/desulfurized effluent having a sulfur content of 100 wppm or less, wherein the effective hydrodesulfurization conditions include a total pressure from 200 psig (1.4 MPa) to 3000 psig (20.7 MPa), a temperature of from 650 O F (343 O C) to 750 O F (399 O C), a liquid hourly space velocity of 0.3 to 5.0 hr -1, a treat gas containing at least 80% hydrogen, and a hydrogen treat gas rate of 500 scf/bbl (84m 3 /m 3) to 10000 scf/bbl (1685 m 3 /m 3); and wherein the bulk mixed metal catalyst and the hydrodesulfurization catalyst are each located in separate reactors. exposing a biocomponent feedstock comprising at least a bio-derived fraction to a bulk mixed metal catalyst in the presence of hydrogen under effective deoxygenation conditions, the bulk mixed metal catalyst comprising at least one Group VI metal and at least one Group VIII metal; wherein the bulk mixed metal catalyst is comprised of at least 90 wt% Mo, W, and Ni, and this portion of the bulk mixed metal catalyst has the formula: (Ni) b (Mo) c d Oz wherein the molar ratio of b:(c+d) is 0.5:1 to 3:1; the molar ratio of c:d is preferably > 0.01:1; the molar ratio of Mo and W is 2:3 to 3:2; and z=[2b+6(c+d)]/2; wherein the effective deoxygenation conditions include a hydrogen partial pressure of from 200 psig (1.4 MPag) to 2000 psig (13.8 MPag), a reaction temperature of from 400 O F to 500 O F (204 O C to 260 O C), a liquid hourly space velocity of from 0.1 hr -1 to 10 hr -1, and a hydrogen treat gas rate from 500 scf/B (84 Nm 3 /m 3) to 10,000 scf/B (1685 Nm 3 /m 3); forming a deoxygenated effluent wherein at least 75 wt% of the oxygen has been removed from the biocomponent feedstock compounds; and exposing at least a portion of the deoxygenated effluent to a hydrodesulfurization catalyst under effective hydrodesulfurization conditions to produce a deoxygenated/desulfurized effluent having a sulfur content of 100 wppm or less, wherein the effective hydrodesulfurization conditions include a total pressure from 200 psig (1.4 MPa) to 3000 psig (20.7 MPa), a temperature of from 650 O F (343 O C) to 750 O F (399 O C), a liquid hourly space velocity of 0.3 to 5.0 hr -1, a treat gas containing at least 80% hydrogen, and a hydrogen treat gas rate of 500 scf/bbl (84m 3 /m 3) to 10000 scf/bbl (1685 m 3 /m 3); and wherein the bulk mixed metal catalyst and the hydrodesulfurization catalyst are each located in separate reactors.