A method for deregistering terminal peripherals in a Machine Type Communication, MTC, system, the method comprising: receiving, by a Machine to Machine, M2M, gateway, a first deregistration request message concerning a terminal peripheral actively sent by each of the terminal peripherals, wherein the first deregistration request message at least contains an identifier of the terminal peripheral to be deregistered; reading, by the M2M gateway, the identifier of each terminal peripheral to be deregistered in the first deregistration request message, generating, by the M2M gateway, a second deregistration request message of the terminal peripherals when determining that a number of the terminal peripherals to be deregistered exceeds a preset threshold, and sending, by the M2M gateway, the second deregistration request message of the terminal peripherals to a M2M service platform or an M2M application, wherein the second deregistration request message at least contains an identifier of the M2M gateway and an identifier list of the terminal peripherals to be deregistered, and wherein the preset threshold is larger than or equal to a maximum number of the terminal peripherals which can be carried by the identifier list of the terminal peripherals to be deregistered of the second deregistration request message; receiving, by the M2M gateway, a first deregistration confirmation message sent by the M2M service platform or the M2M application after the M2M service platform or the M2M application receives the second deregistration request message, deletes information of relevant terminal peripherals according to the identifier list of the terminal peripherals to be deregistered in the second deregistration request message, and generates and sends the first deregistration confirmation message to the M2M gateway, wherein the information of the relevant terminal peripherals at least comprises identifiers of the terminal peripherals to be deregistered, and the identifier of the M2M gateway registered by the terminal peripherals to be deregistered, wherein the first deregistration confirmation message at least contains an identifier list of deregistered terminal peripherals; and deleting, by the M2M gateway from the M2M gateway, information of relevant terminal peripherals according to the identifier list of the deregistered terminal peripherals in the first deregistration confirmation message, and generating and sending a second deregistration confirmation message of the terminal peripherals to the terminal peripherals. receiving, by a Machine to Machine, M2M, gateway, a first deregistration request message concerning a terminal peripheral actively sent by each of the terminal peripherals, wherein the first deregistration request message at least contains an identifier of the terminal peripheral to be deregistered; reading, by the M2M gateway, the identifier of each terminal peripheral to be deregistered in the first deregistration request message, generating, by the M2M gateway, a second deregistration request message of the terminal peripherals when determining that a number of the terminal peripherals to be deregistered exceeds a preset threshold, and sending, by the M2M gateway, the second deregistration request message of the terminal peripherals to a M2M service platform or an M2M application, wherein the second deregistration request message at least contains an identifier of the M2M gateway and an identifier list of the terminal peripherals to be deregistered, and wherein the preset threshold is larger than or equal to a maximum number of the terminal peripherals which can be carried by the identifier list of the terminal peripherals to be deregistered of the second deregistration request message; receiving, by the M2M gateway, a first deregistration confirmation message sent by the M2M service platform or the M2M application after the M2M service platform or the M2M application receives the second deregistration request message, deletes information of relevant terminal peripherals according to the identifier list of the terminal peripherals to be deregistered in the second deregistration request message, and generates and sends the first deregistration confirmation message to the M2M gateway, wherein the information of the relevant terminal peripherals at least comprises identifiers of the terminal peripherals to be deregistered, and the identifier of the M2M gateway registered by the terminal peripherals to be deregistered, wherein the first deregistration confirmation message at least contains an identifier list of deregistered terminal peripherals; and deleting, by the M2M gateway from the M2M gateway, information of relevant terminal peripherals according to the identifier list of the deregistered terminal peripherals in the first deregistration confirmation message, and generating and sending a second deregistration confirmation message of the terminal peripherals to the terminal peripherals.