Method for designing a pair of spectacle progressive ophthalmic lenses intended to be worn by a wearer having a right eye and a left eye, wherein said pair of lenses is made asymmetrical in that for at least one optical parameter (π) defined on the lens intended for the right eye (π RE) and defined on the lens for the left eye (π LE), the amount π RE - π LE is a function of the wearer's handedness, wherein said optical parameter (π) is selected from o any one of central vision optical criteria (CVOC) selected from the group comprising: power in central vision, astigmatism in central vision, high order aberration in central vision, acuity in central vision, prismatic deviation in central vision, ocular deviation, object visual field in central vision, image visual field in central vision, magnification in central vision; o any one of peripheral vision optical criteria (PVOC) selected from the group comprising: power in peripheral vision, astigmatism in peripheral vision, high order aberration in peripheral vision, pupil field ray deviation, object visual field in peripheral vision, image visual field in peripheral vision, prismatic deviation in peripheral vision, magnification in peripheral vision; o any one of global optical criteria selected from the group comprising: magnification of the eye, temple shift, o any one of surface criteria selected from the group comprising: front or back mean curvature, front or back minimum curvature, front or back maximum curvature, front or back cylinder axis, front or back cylinder, front or back mean sphere, front or back maximum sphere, front or back minimum sphere and/or o the maximal value (respectively, minimal value, peak-to-valley value, maximal gradient value, minimal gradient value, maximal slope value, minimal slope value, average value) of any one of the preceding criteria, in one or more useful zones of the lens for near-vision, distant-vision, and intermediate-vision, wherein π RE − π LE / avg π RE π LE = aH + b; wherein o avg denotes the average value, o a and b are constants, o H is a handedness parameter. o any one of central vision optical criteria (CVOC) selected from the group comprising: power in central vision, astigmatism in central vision, high order aberration in central vision, acuity in central vision, prismatic deviation in central vision, ocular deviation, object visual field in central vision, image visual field in central vision, magnification in central vision; o any one of peripheral vision optical criteria (PVOC) selected from the group comprising: power in peripheral vision, astigmatism in peripheral vision, high order aberration in peripheral vision, pupil field ray deviation, object visual field in peripheral vision, image visual field in peripheral vision, prismatic deviation in peripheral vision, magnification in peripheral vision; o any one of global optical criteria selected from the group comprising: magnification of the eye, temple shift, o any one of surface criteria selected from the group comprising: front or back mean curvature, front or back minimum curvature, front or back maximum curvature, front or back cylinder axis, front or back cylinder, front or back mean sphere, front or back maximum sphere, front or back minimum sphere and/or o the maximal value (respectively, minimal value, peak-to-valley value, maximal gradient value, minimal gradient value, maximal slope value, minimal slope value, average value) of any one of the preceding criteria, o avg denotes the average value, o a and b are constants, o H is a handedness parameter.