mhurhangee/ep-ind-claims huggingface dataset:
A vaccine for use in protecting a piglet against porcine circovirus type 2 or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, wherein the piglet has PCV2 maternal antibodies and wherein the vaccine comprises an immunogenic amount of a member selected from the group consisting of: (a) a chimeric nucleic acid molecule of porcine circovirus (PCV1-2) comprising a nucleic acid molecule encoding a nonpathogenic PCV1 which contains the open reading frame 2 capsid gene of a pathogenic PCV2 in place of the ORF2 capsid gene of the PCV1 nucleic acid molecule; (b) a plasmid or viral vector containing the chimeric nucleic acid molecule of (a); and (c) an avirulent, chimeric porcine circovirus type 1 encoding an immunogenic PCV2 ORF2 capsid protein (PCV1-2), wherein the ORF2 capsid gene of a nonpathogenic PCV1 is replaced with the ORF2 capsid gene of a pathogenic PCV2. (a) a chimeric nucleic acid molecule of porcine circovirus (PCV1-2) comprising a nucleic acid molecule encoding a nonpathogenic PCV1 which contains the open reading frame 2 capsid gene of a pathogenic PCV2 in place of the ORF2 capsid gene of the PCV1 nucleic acid molecule; (b) a plasmid or viral vector containing the chimeric nucleic acid molecule of (a); and (c) an avirulent, chimeric porcine circovirus type 1 encoding an immunogenic PCV2 ORF2 capsid protein (PCV1-2), wherein the ORF2 capsid gene of a nonpathogenic PCV1 is replaced with the ORF2 capsid gene of a pathogenic PCV2.
An on-body injector for use with a patient with an injection device having an injection port in fluid communication with a delivery tube, the injection port lying on an injection axis, the on-body injector comprising: a bolus reservoir; a pressurized reservoir in fluid communication with the bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis; wherein the button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port to form an injection flow path from the bolus reservoir, through the bolus injection needle, through the delivery tube, and into the patient; and wherein the button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path; further comprising a housing defining an interior track, wherein the pressurized reservoir is a spring coil operable to at least partially uncoil within the interior track when the pressurized reservoir is at least partially filled with a therapeutic agent. a bolus reservoir; a pressurized reservoir in fluid communication with the bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis; wherein the button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port to form an injection flow path from the bolus reservoir, through the bolus injection needle, through the delivery tube, and into the patient; and wherein the button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path; further comprising a housing defining an interior track, wherein the pressurized reservoir is a spring coil operable to at least partially uncoil within the interior track when the pressurized reservoir is at least partially filled with a therapeutic agent.
An air conditioner comprising: a main body; a fan configured to cause air to flow through the main body; a water reservoir detachably disposed on an upper portion of the main body; a humidifying fabric member disposed inside the main body and configured to receive water from the water reservoir; a water collecting tank configured to collect water that flows from the humidifying fabric member; and a pump configured to pump the water in the water collecting tank to the water reservoir through a suction hole, wherein a bottom of the water collecting tank is formed to be downwardly inclined toward one portion of the bottom and the suction hole of the pump is disposed adjacent to the one portion, and characterized in that: a collecting groove that is lower than the bottom of the water collecting tank is formed at the one portion of the bottom of the water collecting tank, and the suction hole of the pump is disposed adjacent to the collecting groove. a main body; a fan configured to cause air to flow through the main body; a water reservoir detachably disposed on an upper portion of the main body; a humidifying fabric member disposed inside the main body and configured to receive water from the water reservoir; a water collecting tank configured to collect water that flows from the humidifying fabric member; and a pump configured to pump the water in the water collecting tank to the water reservoir through a suction hole, wherein a bottom of the water collecting tank is formed to be downwardly inclined toward one portion of the bottom and the suction hole of the pump is disposed adjacent to the one portion, and characterized in that: a collecting groove that is lower than the bottom of the water collecting tank is formed at the one portion of the bottom of the water collecting tank, and the suction hole of the pump is disposed adjacent to the collecting groove. a collecting groove that is lower than the bottom of the water collecting tank is formed at the one portion of the bottom of the water collecting tank, and the suction hole of the pump is disposed adjacent to the collecting groove.
A periostin compound for use in the prevention or treatment of a haematological disorder in a subject, wherein the periostin compound is selected from a periostin protein, or a functional fragment or variant thereof, or a periostin nucleic acid encoding the periostin protein, or encoding the functional fragment or variant thereof, wherein the variant of the periostin protein comprises an amino acid sequence that is at least 80% identical to an amino acid sequence of a human periostin isoform shown in any one of SEQ ID NO: 1 to 7.
An anti-CD47 antibody comprising: a. a heavy chain having each of the CDR sequences set forth in SEQ ID NOs: 49-51 (Kabat annotation) or SEQ ID NOs: 52-54 (IMGT annotation) and a light chain having each of the CDR sequences set forth in SEQ ID NOs: 55, 152 and 57 (Kabat annotation) or SEQ ID NOs: 58, 153 and 60 (IMGT annotation); or b. a heavy chain having each of the CDR sequences set forth in SEQ ID NOs: 49-51 (Kabat annotation) or SEQ ID NOs: 52-54 (IMGT annotation) and a light chain having each of the CDR sequences set forth in SEQ ID NOs: 55-57 (Kabat annotation) or SEQ ID NOs: 58-60 (IMGT annotation). a. a heavy chain having each of the CDR sequences set forth in SEQ ID NOs: 49-51 (Kabat annotation) or SEQ ID NOs: 52-54 (IMGT annotation) and a light chain having each of the CDR sequences set forth in SEQ ID NOs: 55, 152 and 57 (Kabat annotation) or SEQ ID NOs: 58, 153 and 60 (IMGT annotation); or b. a heavy chain having each of the CDR sequences set forth in SEQ ID NOs: 49-51 (Kabat annotation) or SEQ ID NOs: 52-54 (IMGT annotation) and a light chain having each of the CDR sequences set forth in SEQ ID NOs: 55-57 (Kabat annotation) or SEQ ID NOs: 58-60 (IMGT annotation).
A layer-thickness variable slicing method, applicable for layered slicing of a three-dimensional model for 3D printing of a product, characterized by comprising the following steps: for each section of the three-dimensional model perpendicular to a slicing direction, analyzing and identifying a slope angle α, at each slicing position, of each of inner and outer profiles of the three-dimensional model with respect to a slicing direction, and determining a minimum value α min in slope angles α at the same slicing position; determining a layer thickness of each slice corresponding to each slicing position according to a function relationship between the minimum value α min of the slope angles and the layer thickness δ of the slice, δ = k * sinα min, where k ranges from 0.1 to 1, wherein the higher a quality requirement of printing is, the smaller a value of k is; and determining a layer thickness of each slice corresponding to each position of the three-dimensional model of an entire product. for each section of the three-dimensional model perpendicular to a slicing direction, analyzing and identifying a slope angle α, at each slicing position, of each of inner and outer profiles of the three-dimensional model with respect to a slicing direction, and determining a minimum value α min in slope angles α at the same slicing position; determining a layer thickness of each slice corresponding to each slicing position according to a function relationship between the minimum value α min of the slope angles and the layer thickness δ of the slice, δ = k * sinα min, where k ranges from 0.1 to 1, wherein the higher a quality requirement of printing is, the smaller a value of k is; and determining a layer thickness of each slice corresponding to each position of the three-dimensional model of an entire product.
Method for carrying out a test run on a test stand to simulate a test drive of a vehicle along a driving route, whereas an internal combustion engine being connected to a dynamometer on the test stand in order to carry out the test run, and both the internal combustion engine and the dynamometer being controlled by a test stand automation unit according to a set operating control mode (R B) by specifying setpoint values of the test run for the internal combustion engine and for the dynamometer, characterized in that at least one idle operating time (t L) of the internal combustion engine is determined in a time curve of a vehicle speed (v) and in a time curve of a gas pedal position (α) as a time range, during which time range both the vehicle speed (v) and the gas pedal position (α) are zero and/or at least one overrun operating time (ts) of the internal combustion engine is determined in a time curve of an engine speed and in a time curve of a gas pedal position (α) as a time range, during which time range the gas pedal position (α) is zero and the engine speed is greater than a specified idle speed (N L), and in that, in the test stand automation unit, in order to carry out the test run, a specified idle control mode (R L) is set instead of the operating control mode (R B) during the idle operating time (t L), and/or a specified overrun control mode (Rs) is set instead of the operating control mode (R B) during the overrun operating time (ts).
A method of providing a trusted electronic mail service by a system including a delivery server having an associated database containing subscriber details the method characterised in that it comprises the steps of: receiving a registration application from a prospective subscriber, the registration application including predetermined minimum subscriber information and being associated with corresponding proof-of-identity data and/or documentation; authenticating the identity of the prospective subscriber using the proof-of-identity data and/or documentation; creating for the authenticated subscriber a unique subscriber account and an associated secure electronic mailbox, and storing corresponding subscriber details in the database; the delivery server subsequently receiving from the subscriber a nomination of at least one service provider which the subscriber considers to be a source of essential mail items, and storing said nomination in the database in association with the subscriber details; establishing a trusted communications channel between the delivery server and a service provider computer system (310, 320, 330); the delivery server receiving (212a, 212b) mail data directed for delivery to the subscriber from the service provider via said trusted communications channel; the delivery server verifying that the subscriber wishes to receive a mail item corresponding with the mail data in electronic form, by comparison with subscriber details and nominations stored in the database; and in the event that said verification is successful, the delivery server storing the mail item in a data store of the secure electronic mailbox of the subscriber. receiving a registration application from a prospective subscriber, the registration application including predetermined minimum subscriber information and being associated with corresponding proof-of-identity data and/or documentation; authenticating the identity of the prospective subscriber using the proof-of-identity data and/or documentation; creating for the authenticated subscriber a unique subscriber account and an associated secure electronic mailbox, and storing corresponding subscriber details in the database; the delivery server subsequently receiving from the subscriber a nomination of at least one service provider which the subscriber considers to be a source of essential mail items, and storing said nomination in the database in association with the subscriber details; establishing a trusted communications channel between the delivery server and a service provider computer system (310, 320, 330); the delivery server receiving (212a, 212b) mail data directed for delivery to the subscriber from the service provider via said trusted communications channel; the delivery server verifying that the subscriber wishes to receive a mail item corresponding with the mail data in electronic form, by comparison with subscriber details and nominations stored in the database; and in the event that said verification is successful, the delivery server storing the mail item in a data store of the secure electronic mailbox of the subscriber.
An opsonic monoclonal antibody specific for Gram-positive bacteria, comprising at least one light chain and at least one heavy chain, wherein said at least one light chain comprises a polypeptide comprising a light chain variable region consisting of amino acid sequence according to SEQ ID NO: 1, and wherein said at least one heavy chain comprises a polypeptide comprising a heavy chain variable region consisting of an amino acid sequence selected from SEQ ID NOs: 3, 5, 7, and 9.
A cosmetic product, comprising a cosmetic agent for temporarily shaping keratin fibers, comprising a) a cosmetic preparation containing, based on the total weight of the cosmetic preparation, a1) 0.05 to 5.0 wt.% of at least one hydrophobically modified metal oxide powder, selected from the compounds having the INCI names silica dimethyl silylate; a2) 0.1 to 10 wt.% of at least one film-forming polymer; a3) 40 to 95 wt.% ethanol; a4) less than 5 wt.% water; b) a dispensing device having a spray valve; and c) a propellant. a) a cosmetic preparation containing, based on the total weight of the cosmetic preparation, a1) 0.05 to 5.0 wt.% of at least one hydrophobically modified metal oxide powder, selected from the compounds having the INCI names silica dimethyl silylate; a2) 0.1 to 10 wt.% of at least one film-forming polymer; a3) 40 to 95 wt.% ethanol; a4) less than 5 wt.% water; a1) 0.05 to 5.0 wt.% of at least one hydrophobically modified metal oxide powder, selected from the compounds having the INCI names silica dimethyl silylate; a2) 0.1 to 10 wt.% of at least one film-forming polymer; a3) 40 to 95 wt.% ethanol; a4) less than 5 wt.% water; b) a dispensing device having a spray valve; and c) a propellant.
A method for the early detection of a crack in a wheelset for a rail vehicle, wherein a sensor fixedly mounted on the rail vehicle, i.e. not rotating with the wheelset, generates a measurement signal due to a vibration of the wheelset, characterized in that a shift in the natural frequency of a higher order normal mode of the wheelset is determined from the measurement signal as a measure for determining or assessing the crack, whereby the vibration emitted by the driving operation or by a test device on the wheelset is used to excite the normal mode of higher order.
A composition comprising a phosphor having the formula M 7 Al 12-x-y Si x+y O 25-x N x-y C y:A, wherein: 0<x≤ 12, 0<y<x, and 0<x+y≤ 12; M comprises at least one divalent cation; and A comprises a luminescence activator doped in the crystal structure.
Process for bio-1,3-butanediol purification from a fermentation broth comprising the following steps: (a) subjecting the fermentation broth to separation, wherein said step (a) comprises the following steps: (a 1a) microfiltration and (a 2) nanofiltration; or (a 1b) centrifugation and (a 2) nanofiltration; (b) subjecting the product obtained in step (a) to treatment with ion-exchange resins; (c) subjecting the product obtained in step (b) to a first evaporation; (d) subjecting the product obtained in step (c) to a second evaporation; (e) subjecting the product obtained in step (d) to a third evaporation, obtaining purified bio-1,3-butanediol. (a) subjecting the fermentation broth to separation, wherein said step (a) comprises the following steps: (a 1a) microfiltration and (a 2) nanofiltration; or (a 1b) centrifugation and (a 2) nanofiltration; (a 1a) microfiltration and (a 2) nanofiltration; or (a 1b) centrifugation and (a 2) nanofiltration; (b) subjecting the product obtained in step (a) to treatment with ion-exchange resins; (c) subjecting the product obtained in step (b) to a first evaporation; (d) subjecting the product obtained in step (c) to a second evaporation; (e) subjecting the product obtained in step (d) to a third evaporation, obtaining purified bio-1,3-butanediol.
Gantry for a computed tomography device, - wherein the gantry has a carrier frame, a pivot bearing and a rotating frame, - wherein the rotating frame is mounted by means of the pivot bearing such that it can rotate about an axis of rotation relative to the carrier frame and has a first set of rotating frame components (D1, D2), - wherein the carrier frame has a fan for generating an air flow, a pressure channel for guiding the air flow along at least one flow path and a first carrier frame component, wherein the at least one flow path is curved around the axis of rotation, - wherein the pressure channel has a first pressure channel wall, which delimits the pressure channel in a first axial direction, wherein the first axial direction is substantially in parallel with the axis of rotation, wherein the first pressure channel wall has a first set of rotating frame-side openings, which are configured to branch off a first rotating frame air flow from the air flow, wherein the first rotating frame air flow is provided for cooling the first set of rotating frame components (D1, D2), - wherein the pressure channel has a second pressure channel wall, which delimits the pressure channel in at least one radial direction (X, Y), wherein the at least one radial direction (X, Y) is substantially perpendicular to the axis of rotation, characterised in that the second pressure channel wall has a first opening, which is configured to branch off a first carrier frame air flow from the air flow, wherein the first carrier frame air flow is provided for cooling the first carrier frame component. - wherein the gantry has a carrier frame, a pivot bearing and a rotating frame, - wherein the rotating frame is mounted by means of the pivot bearing such that it can rotate about an axis of rotation relative to the carrier frame and has a first set of rotating frame components (D1, D2), - wherein the carrier frame has a fan for generating an air flow, a pressure channel for guiding the air flow along at least one flow path and a first carrier frame component, wherein the at least one flow path is curved around the axis of rotation, - wherein the pressure channel has a first pressure channel wall, which delimits the pressure channel in a first axial direction, wherein the first axial direction is substantially in parallel with the axis of rotation, wherein the first pressure channel wall has a first set of rotating frame-side openings, which are configured to branch off a first rotating frame air flow from the air flow, wherein the first rotating frame air flow is provided for cooling the first set of rotating frame components (D1, D2), - wherein the pressure channel has a second pressure channel wall, which delimits the pressure channel in at least one radial direction (X, Y), wherein the at least one radial direction (X, Y) is substantially perpendicular to the axis of rotation, characterised in that
An isolated glycopeptide comprising Y 1 X 1 Y 2 X 2 X 3 Y 3 X 4 X 5 X 6 Z 1 X 7 W 1 (SEQ ID NO: 1) or salts thereof, wherein W 1 is threonine or serine substituted with a saccharide or polysaccharide wherein X 1, X 3, X 4, and X 7 is each individually and independently E, D, N, or Q; and wherein X 2, X 5, and X 6 is each individually and independently L, I, V, A or F; Y 1, Y 2, and Y 3 are each phenylalanine substituted with -CH 2 SO 3 H, and Z 1 is proline or hydroxyproline.
Method for authenticating the position X(t) of a mobile element, a mobile element comprising at least a GNSS receiver, having a function of estimating the position X(t) of that mobile element, this method comprising, in combination, at least the following steps: • determining one or more items of data associated with the position X(t) of a GNSS receiver, • extracting reference data associated with the position X(t) from a cartographic database, • determining at least one consistency indicator Ic of the position of the mobile element, which establishes a consistency between observable GNSS, using the first item of data associated with the position X(t) of the said receiver and the reference data coming from the cartographic database and associated with the position X(t), • filtering the said indicator or indicators Ic, integrating these values over a path of the mobile element for a given period of time [t 0, t 1], • authenticating the position X(t) of the said mobile element using one or more said consistency indicators Ic and comparing the filtered value of the indicators to a given value. • determining one or more items of data associated with the position X(t) of a GNSS receiver, • extracting reference data associated with the position X(t) from a cartographic database, • determining at least one consistency indicator Ic of the position of the mobile element, which establishes a consistency between observable GNSS, using the first item of data associated with the position X(t) of the said receiver and the reference data coming from the cartographic database and associated with the position X(t), • filtering the said indicator or indicators Ic, integrating these values over a path of the mobile element for a given period of time [t 0, t 1], • authenticating the position X(t) of the said mobile element using one or more said consistency indicators Ic and comparing the filtered value of the indicators to a given value.