A compound of Formula I where: A is NR 1; R 1 is alkyl, alkenyl, cycloalkyl, C 5-7 cycloalkenyl, (cycloalkyl)alkyl, haloalkyl, alkoxyalkyl, (Ar 1)alkyl, (NR 7 R 8)alkyl, N-(R 9)-pyrrolidinyl or N-(R 9)-piperidinyl; R 2 and R 3 taken together is N(R 13)N=C(R 4); R 4 is hydrogen, halo, alkyl, or alkenyl; NR 5 R 6 taken together is or R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; or NR 7 R 8 taken together is selected from the group consisting of pyrrolidinyl, piperidinyl, N-(R 9)-piperazinyl, morpholinyl, and thiomorpholinyl; R 9 is hydrogen, alkyl, alkylcarbonyl, or alkoxycarbonyl; R 10 is phenyl, naphthyl, pyridinyl, pyridinyl N-oxide, quinolinyl, quinolinyl N-oxide, isoquinolinyl, or isoquinolinyl N-oxide, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, haloalkyl, alkoxy, hydroxy, and phenyl; or R 10 is selected from the group consisting of R 11 is hydrogen, halo, alkyl, haloalkyl, or alkoxy; R 12 is selected from the group consisting of R 13 is hydrogen, alkyl, alkenyl, alkoxyalkyl, or benzyl; Ar 1 is phenyl, naphthyl, pyridinyl, or imidazolyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; Ar 2 is phenyl, naphthyl, or pyridinyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; X-Y is aminocarbonyl, oxycarbonyl, methylenecarbonyl, ethylene, or amino(cyano)iminomethyl; Z is N or CH; and the carbon bearing the asterisk is either the configuration or the configuration; wherein "alkyl" means a straight or branched alkyl group composed of 1 to 6 carbons: "alkenyl" means a straight or branched alkyl group composed of 2 to 6 carbons with at least one double bond; "cycloalkyl" means a monocyclic ring system composed of 3 to 7 carbons; "alkoxy" and other terms with a substituted alkyl moiety include straight and branched isomers composed of 1 to 6 carbon atoms for the alkyl moiety: and "haloalkyl" includes all halogenated isomers from monohalo substituted alkyl to perhalo substituted alkyl; or a pharmaceutically acceptable salt thereof. A is NR 1; R 1 is alkyl, alkenyl, cycloalkyl, C 5-7 cycloalkenyl, (cycloalkyl)alkyl, haloalkyl, alkoxyalkyl, (Ar 1)alkyl, (NR 7 R 8)alkyl, N-(R 9)-pyrrolidinyl or N-(R 9)-piperidinyl; R 2 and R 3 taken together is N(R 13)N=C(R 4); R 4 is hydrogen, halo, alkyl, or alkenyl; NR 5 R 6 taken together is or R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; or NR 7 R 8 taken together is selected from the group consisting of pyrrolidinyl, piperidinyl, N-(R 9)-piperazinyl, morpholinyl, and thiomorpholinyl; R 9 is hydrogen, alkyl, alkylcarbonyl, or alkoxycarbonyl; R 10 is phenyl, naphthyl, pyridinyl, pyridinyl N-oxide, quinolinyl, quinolinyl N-oxide, isoquinolinyl, or isoquinolinyl N-oxide, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, haloalkyl, alkoxy, hydroxy, and phenyl; or R 10 is selected from the group consisting of R 11 is hydrogen, halo, alkyl, haloalkyl, or alkoxy; R 12 is selected from the group consisting of R 13 is hydrogen, alkyl, alkenyl, alkoxyalkyl, or benzyl; Ar 1 is phenyl, naphthyl, pyridinyl, or imidazolyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; Ar 2 is phenyl, naphthyl, or pyridinyl, and is substituted with 0-2 substituents selected from the group consisting of halo, alkyl, and haloalkyl; X-Y is aminocarbonyl, oxycarbonyl, methylenecarbonyl, ethylene, or amino(cyano)iminomethyl; Z is N or CH; and the carbon bearing the asterisk is either the configuration or the configuration; wherein "alkyl" means a straight or branched alkyl group composed of 1 to 6 carbons: "alkenyl" means a straight or branched alkyl group composed of 2 to 6 carbons with at least one double bond; "cycloalkyl" means a monocyclic ring system composed of 3 to 7 carbons; "alkoxy" and other terms with a substituted alkyl moiety include straight and branched isomers composed of 1 to 6 carbon atoms for the alkyl moiety: and "haloalkyl" includes all halogenated isomers from monohalo substituted alkyl to perhalo substituted alkyl;