An apparatus comprising: a frame; a microfluidic plate having one or more first fluidic ports in a first side; and a first support bracket that is attached to the frame such that: the microfluidic plate is interposed between the first support bracket and the frame, the first support bracket floats relative to the microfluidic plate and the frame, the microfluidic plate and the frame float relative to one another, and a first side of the first support bracket faces towards the microfluidic plate, wherein: the first support bracket includes a first indexing feature that protrudes from the first side of the first support bracket and is proximate to a first edge of the microfluidic plate, the first support bracket includes a second indexing feature that protrudes from the first side of the first support bracket and is proximate to a second edge of the microfluidic plate, the first support bracket includes a first gasket with at least one seal that is proud of the first side of the first support bracket and is positioned against the first side of the microfluidic plate, the first support bracket supports the first gasket relative to the frame, and the first indexing feature of the first support bracket and the second indexing feature of the first support bracket contact the first edge and the second edge, respectively, of the microfluidic plate (114, 514) when the at least one seal of the first gasket is aligned with a corresponding at least one of the one or more first fluidic ports. a frame; a microfluidic plate having one or more first fluidic ports in a first side; and a first support bracket that is attached to the frame such that: the microfluidic plate is interposed between the first support bracket and the frame, the first support bracket floats relative to the microfluidic plate and the frame, the microfluidic plate and the frame float relative to one another, and a first side of the first support bracket faces towards the microfluidic plate, wherein: the first support bracket includes a first indexing feature that protrudes from the first side of the first support bracket and is proximate to a first edge of the microfluidic plate, the first support bracket includes a second indexing feature that protrudes from the first side of the first support bracket and is proximate to a second edge of the microfluidic plate, the first support bracket includes a first gasket with at least one seal that is proud of the first side of the first support bracket and is positioned against the first side of the microfluidic plate, the first support bracket supports the first gasket relative to the frame, and the first indexing feature of the first support bracket and the second indexing feature of the first support bracket contact the first edge and the second edge, respectively, of the microfluidic plate (114, 514) when the at least one seal of the first gasket is aligned with a corresponding at least one of the one or more first fluidic ports. the microfluidic plate is interposed between the first support bracket and the frame, the first support bracket floats relative to the microfluidic plate and the frame, the microfluidic plate and the frame float relative to one another, and a first side of the first support bracket faces towards the microfluidic plate, wherein: the first support bracket includes a first indexing feature that protrudes from the first side of the first support bracket and is proximate to a first edge of the microfluidic plate, the first support bracket includes a second indexing feature that protrudes from the first side of the first support bracket and is proximate to a second edge of the microfluidic plate, the first support bracket includes a first gasket with at least one seal that is proud of the first side of the first support bracket and is positioned against the first side of the microfluidic plate, the first support bracket supports the first gasket relative to the frame, and the first indexing feature of the first support bracket and the second indexing feature of the first support bracket contact the first edge and the second edge, respectively, of the microfluidic plate (114, 514) when the at least one seal of the first gasket is aligned with a corresponding at least one of the one or more first fluidic ports. the first support bracket includes a first indexing feature that protrudes from the first side of the first support bracket and is proximate to a first edge of the microfluidic plate, the first support bracket includes a second indexing feature that protrudes from the first side of the first support bracket and is proximate to a second edge of the microfluidic plate, the first support bracket includes a first gasket with at least one seal that is proud of the first side of the first support bracket and is positioned against the first side of the microfluidic plate, the first support bracket supports the first gasket relative to the frame, and the first indexing feature of the first support bracket and the second indexing feature of the first support bracket contact the first edge and the second edge, respectively, of the microfluidic plate (114, 514) when the at least one seal of the first gasket is aligned with a corresponding at least one of the one or more first fluidic ports.