A compound of Formula III: or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, or tautomer thereof, wherein: each of X 5, X 6, X 7, and X 8 is independently CR 7 or N; L is NR 2; each W and W' is independently N or CH; each n and p is independently 1, 2, or 3; Y 1 is a bond, -C - or -NR 2 -; Z 1 is a bond, -C -, -N(R 3)- or -SO 2 -; R 1 is straight or branched-C 1 -C 6 alkyl optionally substituted with halogen or -CN, straight or branched -C 2 -C 6 alkene, straight or branched -C 2 -C 6 alkyne optionally substituted with -C 1 -C 3 alkyl, -C 3 -C 4 cycloalkyl optionally substituted with -C 1 -C 3 alkyl or -CN, or -a nonaromatic monocyclic heterocycle, optionally substituted with -C 1 -C 3 alkyl; R 2 is H or -C 1 -C 6 alkyl; R 3 is H or -C 1 -C 6 alkyl; R 5 is H, -C 1 -C 6 alkyl, -C 2 -C 6 alkene, -(C 0 -C 3 alkyl)-(C 3 -C 6)cycloalkyl, -(C 2 -C 6 alkyl)-O-(C 1 -C 3 alkyl), -(C 2 -C 6 alkyl)-O-(C 3 -C 6)cycloalkyl, -(C 2 -C 6 alkyl)-O-aryl, -(C 2 -C 6 alkyl)-O-heteroaryl, -(C 2 -C 6 alkyl)-NR 8 R 9, -(C 1 -C 3 alkyl)heteroaryl or -(C 1 -C 3 alkyl)aryl, wherein R 5 is optionally substituted; R 6 is selected from the group consisting of -CN, -NO 2, -CO 2 H, C -Rx; -CO 2 Rx; and -CO 2 NRxRy, wherein Rx and Ry are each independently -C 1 -C 6 alkyl, and wherein Rx and Ry, when taken together with the nitrogen to which they are attached, form a heterocycle containing from one to three heteroatoms selected from N, O, and S; R 7 is H, F, Cl, -CF 3, -CN, -CO 2 -alkyl, -C 1 -C 6 alkyl, -C 3 -C 7 (cycloalkyl), -O-(C 1 -C 6 alkyl), -OCF 3, -SO 2 NH 2 or SO 2 -alkyl; and R 8 and R 9 are each independently H, -C 1 -C 6 alkyl, -(C 0 -C 6 alkyl)aryl, C 0 -C 3 alkyl)-C 3 -C 6 (cycloalkyl), -C -C 1 -C 3 alkyl, -C -C 2 -C 3 alkene; or R 3 and R 4, when taken together with the nitrogen to which they are attached, can form a heterocycle containing from one to three heteroatoms selected from N, O, and S, and wherein R 8 and R 9 are optionally substituted. each of X 5, X 6, X 7, and X 8 is independently CR 7 or N; L is NR 2; each W and W' is independently N or CH; each n and p is independently 1, 2, or 3; Y 1 is a bond, -C - or -NR 2 -; Z 1 is a bond, -C -, -N(R 3)- or -SO 2 -; R 1 is straight or branched-C 1 -C 6 alkyl optionally substituted with halogen or -CN, straight or branched -C 2 -C 6 alkene, straight or branched -C 2 -C 6 alkyne optionally substituted with -C 1 -C 3 alkyl, -C 3 -C 4 cycloalkyl optionally substituted with -C 1 -C 3 alkyl or -CN, or -a nonaromatic monocyclic heterocycle, optionally substituted with -C 1 -C 3 alkyl; straight or branched -C 2 -C 6 alkene, straight or branched -C 2 -C 6 alkyne optionally substituted with -C 1 -C 3 alkyl, -C 3 -C 4 cycloalkyl optionally substituted with -C 1 -C 3 alkyl or -CN, or -a nonaromatic monocyclic heterocycle, optionally substituted with -C 1 -C 3 alkyl; R 2 is H or -C 1 -C 6 alkyl; R 3 is H or -C 1 -C 6 alkyl; R 5 is H, -C 1 -C 6 alkyl, -C 2 -C 6 alkene, -(C 0 -C 3 alkyl)-(C 3 -C 6)cycloalkyl, -(C 2 -C 6 alkyl)-O-(C 1 -C 3 alkyl), -(C 2 -C 6 alkyl)-O-(C 3 -C 6)cycloalkyl, -(C 2 -C 6 alkyl)-O-aryl, -(C 2 -C 6 alkyl)-O-heteroaryl, -(C 2 -C 6 alkyl)-NR 8 R 9, -(C 1 -C 3 alkyl)heteroaryl or -(C 1 -C 3 alkyl)aryl, wherein R 5 is optionally substituted; R 6 is selected from the group consisting of -CN, -NO 2, -CO 2 H, C -Rx; -CO 2 Rx; and -CO 2 NRxRy, wherein Rx and Ry are each independently -C 1 -C 6 alkyl, and wherein Rx and Ry, when taken together with the nitrogen to which they are attached, form a heterocycle containing from one to three heteroatoms selected from N, O, and S; R 7 is H, F, Cl, -CF 3, -CN, -CO 2 -alkyl, -C 1 -C 6 alkyl, -C 3 -C 7 (cycloalkyl), -O-(C 1 -C 6 alkyl), -OCF 3, -SO 2 NH 2 or SO 2 -alkyl; and R 8 and R 9 are each independently H, -C 1 -C 6 alkyl, -(C 0 -C 6 alkyl)aryl, C 0 -C 3 alkyl)-C 3 -C 6 (cycloalkyl), -C -C 1 -C 3 alkyl, -C -C 2 -C 3 alkene; or R 3 and R 4, when taken together with the nitrogen to which they are attached, can form a heterocycle containing from one to three heteroatoms selected from N, O, and S, and wherein R 8 and R 9 are optionally substituted.