A compound according to formula 1, or a stereoisomer, tautomer, salt, or hydrate thereof: wherein: each W 1 through W 6 is independently a carbon atom or a nitrogen atom with the proviso that when any W 1 through W 6 is N, then the corresponding substituent(s) X 1 through X 6 is (are) absent; each X 1 through X 3 is independently selected from hydrogen, hydroxy, halogen, optionally substituted C 1 -C 8 alkyl, C 1 -C 8 alkoxy, trifluoromethyl, nitro, cyano, primary, secondary or tertiary amino; each X 5 and X 6 is independently selected from hydrogen and C 1 -C 8 alkyl; X 4 is selected from hydrogen, halogen, or is selected from the following groups: wherein: m is an integer from 1 to 4, and n is an integer from 0 to 4; R 2 is selected from optionally substituted aryl, or heteroaryl, -(CH 2) p -M 1 -aryl substituted by a substituent independently selected from a group consisting of hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, methylenedioxy, trimethylene, cyano, nitro, tertiary amino, dimethylamino, carboxamide, C 1 -C 8 alkylsulfonyl, C 1 -C 8 alkylthio, optionally substituted aryl or heteroaryl, wherein M 1 is O or S; and p is an integer from 1 to 5; R 3 is selected from optionally substituted aryl, heteroaryl, -(CH 2) o -aryl, and -(CH 2) o -heteroaryl, substituted by a substituent independently selected from a group consisting of hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, C 1 -C 8 alkyl, cyano, nitro, primary, secondary or tertiary amino, carboxamide, and optionally substituted aryl or heteroaryl, wherein o is from 0 to 5; Y 1 is: Y 2 is independently selected from: and R 1 is independently selected from optionally substituted heterocyclyl, heterocyclylalkyl, and heteroarylalkyl, wherein substitutions are selected from hydrogen, C 1 -C 8 alkyl, hydroxy, C 1 -C 8 alkoxy, amino, carboxamido, sulfonamido, and cyano. each W 1 through W 6 is independently a carbon atom or a nitrogen atom with the proviso that when any W 1 through W 6 is N, then the corresponding substituent(s) X 1 through X 6 is (are) absent; each X 1 through X 3 is independently selected from hydrogen, hydroxy, halogen, optionally substituted C 1 -C 8 alkyl, C 1 -C 8 alkoxy, trifluoromethyl, nitro, cyano, primary, secondary or tertiary amino; each X 5 and X 6 is independently selected from hydrogen and C 1 -C 8 alkyl; X 4 is selected from hydrogen, halogen, or is selected from the following groups: wherein: m is an integer from 1 to 4, and n is an integer from 0 to 4; R 2 is selected from optionally substituted aryl, or heteroaryl, -(CH 2) p -M 1 -aryl substituted by a substituent independently selected from a group consisting of hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, methylenedioxy, trimethylene, cyano, nitro, tertiary amino, dimethylamino, carboxamide, C 1 -C 8 alkylsulfonyl, C 1 -C 8 alkylthio, optionally substituted aryl or heteroaryl, wherein M 1 is O or S; and p is an integer from 1 to 5; R 3 is selected from optionally substituted aryl, heteroaryl, -(CH 2) o -aryl, and -(CH 2) o -heteroaryl, substituted by a substituent independently selected from a group consisting of hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, C 1 -C 8 alkyl, cyano, nitro, primary, secondary or tertiary amino, carboxamide, and optionally substituted aryl or heteroaryl, wherein o is from 0 to 5; Y 1 is: Y 2 is independently selected from: and R 1 is independently selected from optionally substituted heterocyclyl, heterocyclylalkyl, and heteroarylalkyl, wherein substitutions are selected from hydrogen, C 1 -C 8 alkyl, hydroxy, C 1 -C 8 alkoxy, amino, carboxamido, sulfonamido, and cyano.