mhurhangee/ep-ind-claims huggingface dataset:
A non-naturally occurring or engineered CRISPR-Cas system guide RNA, optionally chimeric single guide RNA molecule (sgRNA), comprising a guide sequence capable of hybridizing to a target sequence in a genomic locus of interest in a cell, and capable of effecting the manipulation of a target nucleic acid within a prokaryotic or eukaryotic cell when in complex within the cell with a CRISPR protein, wherein architecture of the guide RNA or optionally sgRNA comprises a modification selected from the following modifications, corresponding with +85 sgRNA architecture having a 20 nucleotide guide sequence at positions 1 to 20 and the sequence GUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAGUCCGUUAUCAACUUGA AAAAGUGGCACCGAGUCGGUGCUUUUUU at positions 21 to 102: - replacement of a poly U tract (22-25 with respect to the position numbering of +85 sgRNA architecture) with poly C; - replacement of a poly A tract (46-49 with respect to the position numbering of +85 sgRNA architecture) with poly G; - replacement of bases acuu and aagu in stemloop 2 with complimentary GC-rich regions of 4 nucleotides; - a G43C mutation (with respect to the position numbering of +85 sgRNA architecture); - a U44G mutation (with respect to the position numbering of +85 sgRNA architecture); - a U50C or U50A mutation (with respect to the position numbering of +85 sgRNA architecture); - a U59A or U59C mutation (with respect to the position numbering of +85 sgRNA architecture); - a G89A or G89C or G89T mutation (with respect to the position numbering of +85 sgRNA architecture); or - a U90A or U90C mutation (with respect to the position numbering of +85 sgRNA architecture). - replacement of a poly U tract (22-25 with respect to the position numbering of +85 sgRNA architecture) with poly C; - replacement of a poly A tract (46-49 with respect to the position numbering of +85 sgRNA architecture) with poly G; - replacement of bases acuu and aagu in stemloop 2 with complimentary GC-rich regions of 4 nucleotides; - a G43C mutation (with respect to the position numbering of +85 sgRNA architecture); - a U44G mutation (with respect to the position numbering of +85 sgRNA architecture); - a U50C or U50A mutation (with respect to the position numbering of +85 sgRNA architecture); - a U59A or U59C mutation (with respect to the position numbering of +85 sgRNA architecture); - a G89A or G89C or G89T mutation (with respect to the position numbering of +85 sgRNA architecture); or - a U90A or U90C mutation (with respect to the position numbering of +85 sgRNA architecture).
A defect detecting device for detecting a defect in bag making and for use in a bag making apparatus that intermittently feeds a sheet panel (10, 11) having a web shape in a longitudinal direction of the sheet panel (10, 11), the defect detecting device characterized by comprising a detection unit, the detection unit comprising a support characterized in that it further comprises: an arm supported by the support swingably around a swing shaft; and a sensor for detecting a displacement of the arm relative to the support, the arm comprising a first contactor and a second contactor that are spaced at a predetermined angular distance from each other around the swing shaft, the defect detecting device further comprising a movement mechanism for moving the detection unit between a first position where the first and second contactors are away from a feed plane for the sheet panel (10, 11) and a second position where the first and second contactors (620, 621) reach the feed plane, the movement mechanism being configured to, during a feed phase of the sheet panel (10, 11), keep the detection unit located at the first position, and to, during a pause phase of the sheet panel (10, 11), move the detection unit to the second position and then move the detection unit from the second position, the defect detecting device further comprising a determination part configured to determine whether the defect is present at least based on data from the sensor obtained when the detection unit is located at the second position. the defect detecting device characterized by comprising a detection unit, the detection unit comprising a support characterized in that it further comprises: an arm supported by the support swingably around a swing shaft; and a sensor for detecting a displacement of the arm relative to the support, the arm comprising a first contactor and a second contactor that are spaced at a predetermined angular distance from each other around the swing shaft, the defect detecting device further comprising a movement mechanism for moving the detection unit between a first position where the first and second contactors are away from a feed plane for the sheet panel (10, 11) and a second position where the first and second contactors (620, 621) reach the feed plane, the movement mechanism being configured to, during a feed phase of the sheet panel (10, 11), keep the detection unit located at the first position, and to, during a pause phase of the sheet panel (10, 11), move the detection unit to the second position and then move the detection unit from the second position, the defect detecting device further comprising a determination part configured to determine whether the defect is present at least based on data from the sensor obtained when the detection unit is located at the second position.
An image fusion workstation for an image-based fusion of an endoscopic image of an anatomical region generated by an endoscope and an ultrasound image of the anatomical region generated by a laparoscopic ultrasound probe, the image fusion workstation comprising: an image fusion controller, wherein, responsive to a communication of the endoscopic image and the ultrasound image, the image fusion controller is configured to control the fusion between the endoscopic image and the ultrasound image based on an image transformation between an endoscopic image space of the endoscope and an ultrasound image space of the laparoscopic ultrasound probe derived from a detection by the image fusion controller of the laparoscopic ultrasound probe within a field-of-view of the endoscope of the anatomical region; and a display controller, wherein the display controller is configured to control a display of the fusion by the image fusion controller of the endoscopic image and the ultrasound image. an image fusion controller, wherein, responsive to a communication of the endoscopic image and the ultrasound image, the image fusion controller is configured to control the fusion between the endoscopic image and the ultrasound image based on an image transformation between an endoscopic image space of the endoscope and an ultrasound image space of the laparoscopic ultrasound probe derived from a detection by the image fusion controller of the laparoscopic ultrasound probe within a field-of-view of the endoscope of the anatomical region; and a display controller, wherein the display controller is configured to control a display of the fusion by the image fusion controller of the endoscopic image and the ultrasound image.
A semiconductor module comprising: a semiconductor chip; a wiring substrate on which the semiconductor chip is mounted, wherein a wiring pattern electrically connected to the semiconductor chip is formed on a main surface of the wiring substrate; a mounting plate on which the wiring substrate is mounted; a frame body defining a case for accommodating the wiring substrate, together with the mounting plate; and a bus bar electrically connected to the wiring pattern, extending from the case, and being inserted into a side wall of the frame body, wherein the side wall has a rib projecting inward from the frame body side wall, wherein the bus bar has a first region embedded in the side wall, a first end (36a1) of the first embedded region being located at an upper opening of the frame body and a second end (36a2) of said first embedded region being located at the edge of the rib in a direction parallel to the main surface of the wiring substrate, a second region extending from the first end (36a1) of the first region outward from the frame body, and a third region extending downwards from the second end (36a2) of the first region, wherein the third region is bent so as to follow the shape of the projecting rib, and wherein the mounting plate provided with the wiring substrate thereon is attached to the frame body such that the third region is in press-contact with the wiring pattern. a semiconductor chip; a wiring substrate on which the semiconductor chip is mounted, wherein a wiring pattern electrically connected to the semiconductor chip is formed on a main surface of the wiring substrate; a mounting plate on which the wiring substrate is mounted; a frame body defining a case for accommodating the wiring substrate, together with the mounting plate; and a bus bar electrically connected to the wiring pattern, extending from the case, and being inserted into a side wall of the frame body, wherein the side wall has a rib projecting inward from the frame body side wall, wherein the bus bar has a first region embedded in the side wall, a first end (36a1) of the first embedded region being located at an upper opening of the frame body and a second end (36a2) of said first embedded region being located at the edge of the rib in a direction parallel to the main surface of the wiring substrate, a second region extending from the first end (36a1) of the first region outward from the frame body, and a third region extending downwards from the second end (36a2) of the first region, wherein the third region is bent so as to follow the shape of the projecting rib, and wherein the mounting plate provided with the wiring substrate thereon is attached to the frame body such that the third region is in press-contact with the wiring pattern.
A drain rod system, said system including at least two hollow or tubular rods, said rods connected and/or coupled together by one or more connection means, said connection means including a first male portion at least part of which includes a non-circular member having a distal end which is cuboid with chamfered or angled edges and a second female portion at least part of which is configured to receive at least part of the non-circular member extending from the adjacent first male portion, the connection means further including first and second threaded engagement members (10, 14), a circular flange is formed behind the non-circular member, said first threaded member including a thread or threaded portion and at least part of the second threaded member adapted to receive at least part of the thread or threaded portion of said first threaded member, wherein that at least one or both of said threaded members (10, 14) includes a cylindrical grip portion to enable the user to screw together the male and female portions and/or the first and second threaded members by hand, said grip portion including a gnarled, patterned or roughened surface which improves grip, said first male portion including the circular flange that prevents the first threaded member and/or the grip portion from being removed from the rod and characterised in that a cylindrical collar and the non-circular member of the male portion are reattached to a first end of the rod using one or more pins, bars or rivets and the second female portion is attached to an opposite end of the rod using said one or more pins, bars or rivets, that pass through apertures formed in the same, said first threaded member being captive between a substantially planar surface of the collar and the circular flange, and a cylindrical body part of the non-circular member extends through the first threaded member and into the cylindrical collar which is mounted on the end of the rod.
A method for packet clock recovery, performed by an apparatus, the method comprising: acquiring a first loop control value generated with a current short message selection time window; determining accuracy of the first loop control value by using a sliding time window, wherein the sliding time window is set up by using M forward consecutive short message selection time windows based on the current short message selection time window as a starting point; and generating a control parameter for a clock generator according to the determined accuracy to control clock generation and recover a packet clock; wherein acquiring the first loop control value generated with the current short message selection time window comprises: in the current short message selection time window, using a fixed window to sample values from a message received via a packet network; and performing packet pre-processing, de-jitter and de-noise on the sampled values to obtain the first loop control value. acquiring a first loop control value generated with a current short message selection time window; determining accuracy of the first loop control value by using a sliding time window, wherein the sliding time window is set up by using M forward consecutive short message selection time windows based on the current short message selection time window as a starting point; and generating a control parameter for a clock generator according to the determined accuracy to control clock generation and recover a packet clock; wherein acquiring the first loop control value generated with the current short message selection time window comprises: in the current short message selection time window, using a fixed window to sample values from a message received via a packet network; and performing packet pre-processing, de-jitter and de-noise on the sampled values to obtain the first loop control value.
A media ingestion method performed by a media packager node (202, 302, 402, 906) and comprising: generating a segmented media stream from an incoming media stream, wherein each segment comprises a plurality of fragments, each fragment comprising one or more frames of media data; the method being characterized by identifying that the segmented stream is to be distributed using IP multicast and associating the segmented stream with a particular IP multicast group; initiating an HTTP chunked transfer encoding, CTE, session between the media packager node (202, 302, 402, 906) and an origin server node (214, 306A, 306B, 404, 909); for each segment N, performing the following: commencing ingesting, via the CTE session, fragments (416-1... 416-N, 918-1... 918-N) of a segment N via the HTTP CTE session to the origin server node (214, 306A, 306B, 404, 909) before entire media data for the segment N is available, wherein one or more chunks are provided for transmitting each fragment; and sending a last chunk signal to the origin server node (214, 306A, 306B, 404, 909) after all fragments (416-1... 416-N, 918-1... 918-N) of the segment N have been transmitted. generating a segmented media stream from an incoming media stream, wherein each segment comprises a plurality of fragments, each fragment comprising one or more frames of media data; the method being characterized by identifying that the segmented stream is to be distributed using IP multicast and associating the segmented stream with a particular IP multicast group; initiating an HTTP chunked transfer encoding, CTE, session between the media packager node (202, 302, 402, 906) and an origin server node (214, 306A, 306B, 404, 909); for each segment N, performing the following: commencing ingesting, via the CTE session, fragments (416-1... 416-N, 918-1... 918-N) of a segment N via the HTTP CTE session to the origin server node (214, 306A, 306B, 404, 909) before entire media data for the segment N is available, wherein one or more chunks are provided for transmitting each fragment; and sending a last chunk signal to the origin server node (214, 306A, 306B, 404, 909) after all fragments (416-1... 416-N, 918-1... 918-N) of the segment N have been transmitted. commencing ingesting, via the CTE session, fragments (416-1... 416-N, 918-1... 918-N) of a segment N via the HTTP CTE session to the origin server node (214, 306A, 306B, 404, 909) before entire media data for the segment N is available, wherein one or more chunks are provided for transmitting each fragment; and sending a last chunk signal to the origin server node (214, 306A, 306B, 404, 909) after all fragments (416-1... 416-N, 918-1... 918-N) of the segment N have been transmitted.
A method for determining drill center location and drill path for a well into a hydrocarbon formation, comprising: selecting a target region of finite extent within the formation; and solving an optimization problem wherein a drill center location and a drill path are determined subject to a plurality of constraints, one of said constraints being that the drill path must penetrate the target region, characterized in that: an initial target segment in the target region is determined before solving the optimization problem, and in that the solution of the optimization problem is constrained to require that the drill path include the target segment, or, if adjusted later in the optimization, a then-current target segment. selecting a target region of finite extent within the formation; and solving an optimization problem wherein a drill center location and a drill path are determined subject to a plurality of constraints, one of said constraints being that the drill path must penetrate the target region,
A wind turbine nacelle in which are disposed operative components including a gearbox and a generator, wherein a nacelle cover is provided having a bottom cover part which is formed with a number of shallow receptacle regions which underlie the operative components for containing liquid leaked or spilled therefrom, characterised in that the receptacle regions underlie and are associated with respectively the gearbox and generator, and in that flow channels (88,90) are provided between the receptacle regions so that liquid can flow between them.
Timepiece movement including a resonator formed by the cooperation of a balance with a balance spring (7, 7', 7"), said resonator being pivotally mounted between a bar (2, 2', 2") and another part, characterized in that the timepiece movement further includes a device (19, 19', 19") for preventing adhesion of said balance spring against said bar comprising at least one recess and/or protruding portion, defining surface decreasing means (23, 23', 25, 25') formed on the bar (2', 2") and allowing the contact surface to be limited when the faces (15', 16', 17, 18) of said balance spring and of said bar touch each other.
A method of installing an aircraft engine comprising: attaching an inner fixed structure support to an engine core and mounting a first movable portion to the IFS support, wherein the first movable portion is movable relative to the IFS support; wherein the IFS support and the first movable portion form an inner fixed structure around the engine core; coupling a first cable to a forward hoist and a forward attachment feature on the IFS support, coupling a second cable to an aft hoist and an aft attachment feature on the IFS support; raising the aircraft engine to a pylon using the first cable and the second cable with the inner fixed structure positioned around the engine core during the raising; and coupling an engine mount to a pylon mount. attaching an inner fixed structure support to an engine core and mounting a first movable portion to the IFS support, wherein the first movable portion is movable relative to the IFS support; wherein the IFS support and the first movable portion form an inner fixed structure around the engine core; coupling a first cable to a forward hoist and a forward attachment feature on the IFS support, coupling a second cable to an aft hoist and an aft attachment feature on the IFS support; raising the aircraft engine to a pylon using the first cable and the second cable with the inner fixed structure positioned around the engine core during the raising; and coupling an engine mount to a pylon mount.
Hand-held cyclone vacuum cleaner, comprising - a suctioned material container for receiving suctioned material, - a device body which can be releasably connected to the suctioned material container and has a drive unit which is designed to generate a suction air flow, characterised in that an air duct located in the suctioned material container and a suction channel located in the housing body, when the suctioned material container and housing body are in a connected state, have an air path for the suction air flow during operation, which air path is oriented along a flow axis which is parallel to a movement axis when the suctioned material container and the device body are connected. - a suctioned material container for receiving suctioned material, - a device body which can be releasably connected to the suctioned material
An electrochemical cell comprising: an anode assembly having opposite surfaces; and a cathode having at least one folded portion and having ionic continuity with the opposite surfaces of the anode assembly, wherein the anode assembly comprises an anode, and an active metal ion conducting membrane that is disposed between the anode and the cathode, wherein: active metal ion conducting membrane has at least one folded portion; and forms a housing that is impermeable to liquid and gas and defines an internal region which is hermetically sealed from an external region, the active metal ion conducting membrane isolating the anode from the cathode. an anode assembly having opposite surfaces; and a cathode having at least one folded portion and having ionic continuity with the opposite surfaces of the anode assembly, wherein the anode assembly comprises an anode, and an active metal ion conducting membrane that is disposed between the anode and the cathode, wherein: active metal ion conducting membrane has at least one folded portion; and forms a housing that is impermeable to liquid and gas and defines an internal region which is hermetically sealed from an external region, the active metal ion conducting membrane isolating the anode from the cathode. active metal ion conducting membrane has at least one folded portion; and forms a housing that is impermeable to liquid and gas and defines an internal region which is hermetically sealed from an external region, the active metal ion conducting membrane isolating the anode from the cathode.