A head fixation device for use in imaging of a part of a patient using Magnetic Resonance and X-ray imaging, the device comprising: first and second skull engaging clamp members (55, 56) arranged so as to engage the skull from opposite sides so as to locate the skull therebetween; a generally C-shaped support including a base and two legs (51, 53) arranged so that the clamp members (55, 56) are attached to first and second ends of the legs of the C-shaped support and the base of the C-shaped support extends around the head from the first leg to the second leg; and an adjustment system for moving at least one of the clamp members (55, 56) inwardly relative to the other so as to apply a clamping force to the skull; the adjustment system including a coarse adjustment system allowing coarse movement of one leg relative to the other to a position in which the clamp members are brought into engagement with the skull and a fine adjustment system allowing fine movement of said one leg relative to said other leg from said position to apply an adjustable pressure though the clamp members to the skull; wherein the base is fixedly attached to a first one of the legs characterized in that the second leg has a slide element mounting in the base for sliding movement along the base to reduce a spacing between the legs (51, 53); wherein the adjustment system includes a hand operated adjustment component, a screw rotated by the hand operated adjustment component and extending along the base to the second leg and a nut component attached to the slide element of the second leg to drive the slide element along the base; and wherein the hand operated adjustment component of the adjustment system including the coarse adjustment system and the fine adjustment system is located in the base to the side of the C-shaped support thus keeping the adjustment system out of the field of vertical images through the clamped skull taken from the top or bottom as well as from the side and while the screw and the nut component are located in the vertical images they do not cause unacceptable artifacts in the X-ray imaging. first and second skull engaging clamp members (55, 56) arranged so as to engage the skull from opposite sides so as to locate the skull therebetween; a generally C-shaped support including a base and two legs (51, 53) arranged so that the clamp members (55, 56) are attached to first and second ends of the legs of the C-shaped support and the base of the C-shaped support extends around the head from the first leg to the second leg; and an adjustment system for moving at least one of the clamp members (55, 56) inwardly relative to the other so as to apply a clamping force to the skull; the adjustment system including a coarse adjustment system allowing coarse movement of one leg relative to the other to a position in which the clamp members are brought into engagement with the skull and a fine adjustment system allowing fine movement of said one leg relative to said other leg from said position to apply an adjustable pressure though the clamp members to the skull; wherein the base is fixedly attached to a first one of the legs characterized in that the second leg has a slide element mounting in the base for sliding movement along the base to reduce a spacing between the legs (51, 53); wherein the adjustment system includes a hand operated adjustment component, a screw rotated by the hand operated adjustment component and extending along the base to the second leg and a nut component attached to the slide element of the second leg to drive the slide element along the base; and wherein the hand operated adjustment component of the adjustment system including the coarse adjustment system and the fine adjustment system is located in the base to the side of the C-shaped support thus keeping the adjustment system out of the field of vertical images through the clamped skull taken from the top or bottom as well as from the side and while the screw and the nut component are located in the vertical images they do not cause unacceptable artifacts in the X-ray imaging.