A thrombectomy catheter (10; 510) comprising: a catheter body extending from a distal portion (18; 118; 218; 318; 418) toward a proximal portion along a longitudinal axis (111; 311; 511); a high pressure tube (170; 370; 570) extending through a lumen of the catheter body from the proximal portion toward the distal portion (18; 118; 218; 318; 418), the high pressure tube (170; 370; 570) configured for coupling with a fluid source near the proximal portion and terminating in a fluid jet emanator (160; 360) located in the catheter lumen (113; 313), the fluid jet emanator (160; 360) comprising a plurality of fluid jet openings (164; 364) configured to direct a plurality of fluid jets through the catheter lumen (113; 313) toward the proximal portion, wherein the high pressure tube (170; 370; 570) extends along one side of the catheter lumen (113; 313) such that the high pressure tube (170; 370; 570) is off-center within the catheter lumen (113; 313); an inflow orifice (50; 150; 254, 256; 350; 450) formed through a wall of the catheter body in the distal portion, wherein the inflow orifice (50; 150; 254, 256; 350; 450) is located proximally from the fluid jet emanator (160; 360); a radiopaque marker (172; 372) attached to the high pressure tube (170; 370; 570) within an axial length of the inflow orifice (50; 150; 254, 256; 350; 450) as measured along the longitudinal axis, wherein the radiopaque marker (172; 372) is off-center within the catheter lumen (113; 313); and an outflow orifice (40; 140; 240; 340; 440) in the distal portion, wherein the outflow orifice (40; 140; 240; 340; 440) is located proximally of the inflow orifice (50; 150; 254, 256; 350; 450) such that the inflow orifice (50; 150; 254, 256; 350; 450) is located between the outflow orifice (40; 140; 240; 340; 440) and the fluid jet emanator (160; 360). a high pressure tube (170; 370; 570) extending through a lumen of the catheter body from the proximal portion toward the distal portion (18; 118; 218; 318; 418), the high pressure tube (170; 370; 570) configured for coupling with a fluid source near the proximal portion and terminating in a fluid jet emanator (160; 360) located in the catheter lumen (113; 313), the fluid jet emanator (160; 360) comprising a plurality of fluid jet openings (164; 364) configured to direct a plurality of fluid jets through the catheter lumen (113; 313) toward the proximal portion, wherein the high pressure tube (170; 370; 570) extends along one side of the catheter lumen (113; 313) such that the high pressure tube (170; 370; 570) is off-center within the catheter lumen (113; 313); an inflow orifice (50; 150; 254, 256; 350; 450) formed through a wall of the catheter body in the distal portion, wherein the inflow orifice (50; 150; 254, 256; 350; 450) is located proximally from the fluid jet emanator (160; 360); a radiopaque marker (172; 372) attached to the high pressure tube (170; 370; 570) within an axial length of the inflow orifice (50; 150; 254, 256; 350; 450) as measured along the longitudinal axis, wherein the radiopaque marker (172; 372) is off-center within the catheter lumen (113; 313); and an outflow orifice (40; 140; 240; 340; 440) in the distal portion, wherein the outflow orifice (40; 140; 240; 340; 440) is located proximally of the inflow orifice (50; 150; 254, 256; 350; 450) such that the inflow orifice (50; 150; 254, 256; 350; 450) is located between the outflow orifice (40; 140; 240; 340; 440) and the fluid jet emanator (160; 360).