A polymeric scaffold, being of Formula (Icc): wherein: the polymer is a hydroxyl polymeric carrier having a molecular weight ranging from 2 kDa to 300 kDa and the polymer is not a polyacetal or a polyketal, wherein the one or more -OH groups are not the hydroxyl groups of one or more -COOH connected to the polymer, each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa; L D1 comprises -X-(CH 2) v -C(=O)- with X directly connected to the carbonyl group of- u -C(=O), in which X is CH 2, O, or NH, and v is an integer from 1 to 6; each occurrence of in independently is a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; in which each u is 1, and the in between L D1 and D denotes direct or indirect attachment of D to L D1; each occurrence of independently is a second linker not yet connected to a protein based recognition molecule (PBRM), in which L P2 is a moiety containing a functional group that is capable of forming a covalent bond with a functional group of a PBRM, each u is 1, and the in between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1, and each occurrence of the second linker is distinct from each occurrence of the first linker; in between L P2 and PBRM denotes direct or indirect attachment of PBRM to L P2; each occurrence of PBRM independently has a molecular weight of less than 200 kDa; m is an integer from 1 to 2200, m 1 is an integer from 1 to 660, m 2 is an integer from 1 to 300, m 3 is an integer from 0 to 110, m 4 is an integer from 1 to 60; and the sum of m, m 1, m 2, m 3 and m 4 ranges from 4 to 2200. the polymer is a hydroxyl polymeric carrier having a molecular weight ranging from 2 kDa to 300 kDa and the polymer is not a polyacetal or a polyketal, wherein the one or more -OH groups are not the hydroxyl groups of one or more -COOH connected to the polymer, each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa; L D1 comprises -X-(CH 2) v -C(=O)- with X directly connected to the carbonyl group of- u -C(=O), in which X is CH 2, O, or NH, and v is an integer from 1 to 6; each occurrence of in independently is a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; in which each u is 1, and the in between L D1 and D denotes direct or indirect attachment of D to L D1; each occurrence of independently is a second linker not yet connected to a protein based recognition molecule (PBRM), in which L P2 is a moiety containing a functional group that is capable of forming a covalent bond with a functional group of a PBRM, each u is 1, and the in between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1, and each occurrence of the second linker is distinct from each occurrence of the first linker; in between L P2 and PBRM denotes direct or indirect attachment of PBRM to L P2; each occurrence of PBRM independently has a molecular weight of less than 200 kDa; m is an integer from 1 to 2200, m 1 is an integer from 1 to 660, m 2 is an integer from 1 to 300, m 3 is an integer from 0 to 110, m 4 is an integer from 1 to 60; and the sum of m, m 1, m 2, m 3 and m 4 ranges from 4 to 2200.