mhurhangee/ep-ind-claims huggingface dataset:
An aqueous liquid composition comprising a peptide and an excipient, and having a pH of 3 - 6: wherein the peptide is selected from the group consisting of the following and, a peptide consisting of the amino acid sequence shown by Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu (SEQ ID NO: 1), and a peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, wherein 1 to 3 amino acids are deleted, substituted and/or added, and having a cytotoxic T cell-inducing ability; and the excipient comprises both the following and, and optionally comprises the following, one or more kinds of alpha hydroxy acids selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and pharmacologically acceptable salts thereof, one or more kinds of dicarboxylic acids selected from the group consisting of malonic acid, succinic acid, glutaric acid, maleic acid and pharmacologically acceptable salts thereof, and methionine, wherein the content per volume of alpha hydroxy acid is 1 - 100 mM, and the content per volume of methionine is 1 - 300 mM. wherein the peptide is selected from the group consisting of the following and, a peptide consisting of the amino acid sequence shown by Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu (SEQ ID NO: 1), and a peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, wherein 1 to 3 amino acids are deleted, substituted and/or added, and having a cytotoxic T cell-inducing ability; and the excipient comprises both the following and, and optionally comprises the following, one or more kinds of alpha hydroxy acids selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and pharmacologically acceptable salts thereof, one or more kinds of dicarboxylic acids selected from the group consisting of malonic acid, succinic acid, glutaric acid, maleic acid and pharmacologically acceptable salts thereof, and methionine, a peptide consisting of the amino acid sequence shown by Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu (SEQ ID NO: 1), and a peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, wherein 1 to 3 amino acids are deleted, substituted and/or added, and having a cytotoxic T cell-inducing ability; and the excipient comprises both the following and, and optionally comprises the following, one or more kinds of alpha hydroxy acids selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and pharmacologically acceptable salts thereof, one or more kinds of dicarboxylic acids selected from the group consisting of malonic acid, succinic acid, glutaric acid, maleic acid and pharmacologically acceptable salts thereof, and methionine, wherein the content per volume of alpha hydroxy acid is 1 - 100 mM, and the content per volume of methionine is 1 - 300 mM.
Method for manufacture and filling with a liquid of a tubular packaging, comprising the steps of: providing a container with the liquid therein, providing a tube having a length and an internal diameter (D i), filling the tube at least partially with the liquid from the container, dividing the tube into a number of tubular segments by means of successive welding operations, and separating the tubular segments from each other at the position of welded seams formed by the welding operations, wherein after each welding operation the tube is displaced in controlled manner over a distance corresponding to a desired length of the tubular segments, or a multiple thereof, characterised in that the liquid is a sterile liquid and the tube is filled in a sterile manner from the container. providing a container with the liquid therein, providing a tube having a length and an internal diameter (D i), filling the tube at least partially with the liquid from the container, dividing the tube into a number of tubular segments by means of successive welding operations, and separating the tubular segments from each other at the position of welded seams formed by the welding operations, wherein after each welding operation the tube is displaced in controlled manner over a distance corresponding to a desired length of the tubular segments, or a multiple thereof, characterised in that the liquid is a sterile liquid and the tube is filled in a sterile manner from the container.
Mixture of positional isomers of aminaphtone consisting of 3-methyl-1,2,4-naphthalenetriol 2-(4-aminobenzoate) (isomer A) and of 3-methyl-1,2,4-naphthalenetriol 1-(4- aminobenzoate) (isomer B), characterized in that 3-methyl-1,2,4-naphthalenetriol 1-(4- aminobenzoate) (isomer B) is at least 95% by weight of said mixture.
A system comprising: a compressor having a motor; a refrigeration circuit including an evaporator and a condenser fluidly coupled to said compressor; a first sensor configured to produce a signal indicative of one of current and power drawn by said motor; a second sensor configured to produce a signal indicative of a saturated condensing temperature; a third sensor configured to produce a signal indicative of a liquid-line temperature; and processing circuitry configured to process said current or power signal to determine a derived condenser temperature and to compare said derived condenser temperature to said saturated condensing temperature received from said second sensor to determine a subcooling and a refrigerant charge level associated with the subcooling of said refrigeration circuit. a compressor having a motor; a refrigeration circuit including an evaporator and a condenser fluidly coupled to said compressor; a first sensor configured to produce a signal indicative of one of current and power drawn by said motor; a second sensor configured to produce a signal indicative of a saturated condensing temperature; a third sensor configured to produce a signal indicative of a liquid-line temperature; and processing circuitry configured to process said current or power signal to determine a derived condenser temperature and to compare said derived condenser temperature to said saturated condensing temperature received from said second sensor to determine a subcooling and a refrigerant charge level associated with the subcooling of said refrigeration circuit.
Hydraulic pulse damper having an elastic hydraulic buffer volume and having a volume flow throttle (90, 290) which is in fluidic communication with the buffer volume, wherein a first delimiting surface encloses the buffer volume, wherein the first delimiting surface comprises a spring-loaded inner diaphragm surface of a diaphragm (50, 214), characterized in that the hydraulic pulse damper has a temperature-stabilizing test oil tank, wherein the volume flow throttle (90, 290) is formed by an elongate, loop-shaped line and is arranged in the test oil tank.
A composition comprising a recombinant DNA polymerase, the recombinant DNA polymerase comprising: a mutation at a site corresponding to E375 relative to the wild-type Φ29 polymerase of SEQ ID NO: 1, which mutation introduces a positively charged or aromatic amino acid residue at the site, wherein the recombinant DNA polymerase is at least 70% identical to the wild-type Φ29 polymerase of SEQ ID NO:1, and wherein the recombinant DNA polymerase displays a reduced K m, an increased V max, or a reduced branching rate for a nucleotide analogue that comprises from 4 to 6 phosphates, as compared to the wild-type polymerase. a mutation at a site corresponding to E375 relative to the wild-type Φ29 polymerase of SEQ ID NO: 1, which mutation introduces a positively charged or aromatic amino acid residue at the site, wherein the recombinant DNA polymerase is at least 70% identical to the wild-type Φ29 polymerase of SEQ ID NO:1, and wherein the recombinant DNA polymerase displays a reduced K m, an increased V max, or a reduced branching rate for a nucleotide analogue that comprises from 4 to 6 phosphates, as compared to the wild-type polymerase.
A battery management system comprising: a plurality of integrated circuits each configured to perform a cell balancing control function of a corresponding battery module among a plurality of battery modules; and a battery controller configured to communicate with the integrated circuits to control cell balancing of the battery modules, and to repeatedly perform a first mode for sequentially activating cell balancing of the battery modules during a first period and a second mode for stopping the cell balancing of the battery modules during a second period that follows the first period, every predetermined cycle, when cell balancing is required for the battery modules, characterised in that the battery controller is configured to change an order in which the cell balancing of the battery modules is activated in the first mode for each cycle. a plurality of integrated circuits each configured to perform a cell balancing control function of a corresponding battery module among a plurality of battery modules; and a battery controller configured to communicate with the integrated circuits to control cell balancing of the battery modules, and to repeatedly perform a first mode for sequentially activating cell balancing of the battery modules during a first period and a second mode for stopping the cell balancing of the battery modules during a second period that follows the first period, every predetermined cycle, when cell balancing is required for the battery modules, characterised in that the battery controller is configured to change an order in which the cell balancing of the battery modules is activated in the first mode for each cycle.
A laser unit for performing intrastromal ophthalmic laser surgery, wherein a cornea defines a visual axis and has a thickness "T", comprising: means for generating a pulsed laser beam, wherein the duration of each pulse in the beam is less than approximately one picosecond; means for directing and focusing the beam onto a series of focal spots in the stroma for Laser Induced Optical Breakdown (LIOB) of stromal tissue at each focal spot; and means being adapted for moving the focal spot in the stroma to create a plurality of cuts, wherein each cut is made on portions of a respective cylindrical surface, wherein the respective cylindrical surfaces are centered on the visual axis of the cornea, and further wherein each cylindrical surface has an anterior end and a posterior end, with the posterior end of the cut being located no deeper in the stroma than 0.9T from an anterior surface of the eye, and the anterior end of the cylindrical cut is located in the stroma more than at least eight microns in a posterior direction from Bowman's capsule in the cornea, characterised in that the portions of the cylindrical surfaces subjected to LIOB define diametrically opposed arc segments wherein each arc segment extends through an arc in a range between five degrees and one hundred and sixty degrees. means for generating a pulsed laser beam, wherein the duration of each pulse in the beam is less than approximately one picosecond; means for directing and focusing the beam onto a series of focal spots in the stroma for Laser Induced Optical Breakdown (LIOB) of stromal tissue at each focal spot; and means being adapted for moving the focal spot in the stroma to create a plurality of cuts, wherein each cut is made on portions of a respective cylindrical surface, wherein the respective cylindrical surfaces are centered on the visual axis of the cornea, and further wherein each cylindrical surface has an anterior end and a posterior end, with the posterior end of the cut being located no deeper in the stroma than 0.9T from an anterior surface of the eye, and the anterior end of the cylindrical cut is located in the stroma more than at least eight microns in a posterior direction from Bowman's capsule in the cornea, characterised in that the portions of the cylindrical surfaces subjected to LIOB define diametrically opposed arc segments wherein each arc segment extends through an arc in a range between five degrees and one hundred and sixty degrees.
A positron emission tomography -magnetic resonance imaging apparatus, comprising: a gantry including: a static magnetic field magnet configured to generate a static magnetic field in a bore having an approximately cylindrical shape; a gradient coil disposed on an inner circumference side of the static magnetic field magnet and configured to apply a gradient magnetic field to an object disposed in the bore; and a radio frequency coil disposed on an inner circumference side of the gradient coil and configured to apply a radio frequency magnetic field to the object; and a PET detector (13a,13c) configured to detect gamma rays emitted from a positron-emitting radionuclide injected into the object; CHARACTERISED BY: a retainer or a moving mechanism supported by the static magnetic field magnet outside the gantry and configured to cause the PET detector (13a, 13c) to move in the gantry along the axial direction of the bore. a gantry including: a static magnetic field magnet configured to generate a static magnetic field in a bore having an approximately cylindrical shape; a gradient coil disposed on an inner circumference side of the static magnetic field magnet and configured to apply a gradient magnetic field to an object disposed in the bore; and a radio frequency coil disposed on an inner circumference side of the gradient coil and configured to apply a radio frequency magnetic field to the object; and a static magnetic field magnet configured to generate a static magnetic field in a bore having an approximately cylindrical shape; a gradient coil disposed on an inner circumference side of the static magnetic field magnet and configured to apply a gradient magnetic field to an object disposed in the bore; and a radio frequency coil disposed on an inner circumference side of the gradient coil and configured to apply a radio frequency magnetic field to the object; and a PET detector (13a,13c) configured to detect gamma rays emitted from a positron-emitting radionuclide injected into the object; a retainer or a moving mechanism supported by the static magnetic field magnet outside the gantry and configured to cause the PET detector (13a, 13c) to move in the gantry along the axial direction of the bore.
A process for producing a conductive structure comprising at least one nanowire, especially a silicon nanowire, having a diameter of less than 50 nm, with which contacts are formed via at least two sites with electrodes (11, 13, 30), and wherein the at least one nanowire and the electrodes (11, 13, 30) are arranged in one plane on a substrate (1, 29), wherein a) catalytically active metal nanoparticles having a diameter in the range of 0.5-50 nm are deposited on locally defined nucleation surfaces on the surface of an insulating substrate (1, 29), b) the surface and the metal nanoparticles deposited thereon are exposed to a gas stream comprising at least one gaseous silicon component at a temperature in the range of 300-1100°C over a period in the range of 10-200 min, forming at least one nanowire protruding from the substrate and having a length in the range of 5-200 μm; c) this at least one nanowire protruding from the surface of the substrate is laid down into a plane by placing a secondary substrate having a contact face corresponding to the surface of the insulating substrate (1,29) on top; d) and the at least one nanowire laid down on the insulating substrate (1,29) contacts at two different sites with electrodes (11, 13, 30), for which a first electrode is generated over the centre of the corresponding nucleation surface and a second electrode arranged in an annular arrangement outside the first electrode. a) catalytically active metal nanoparticles having a diameter in the range of 0.5-50 nm are deposited on locally defined nucleation surfaces on the surface of an insulating substrate (1, 29), b) the surface and the metal nanoparticles deposited thereon are exposed to a gas stream comprising at least one gaseous silicon component at a temperature in the range of 300-1100°C over a period in the range of 10-200 min, forming at least one nanowire protruding from the substrate and having a length in the range of 5-200 μm; c) this at least one nanowire protruding from the surface of the substrate is laid down into a plane by placing a secondary substrate having a contact face corresponding to the surface of the insulating substrate (1,29) on top; d) and the at least one nanowire laid down on the insulating substrate (1,29) contacts at two different sites with electrodes (11, 13, 30), for which a first electrode is generated over the centre of the corresponding nucleation surface and a second electrode arranged in an annular arrangement outside the first electrode.
Photovoltaic device comprising a wafer, characterized in that it comprises a plurality of discontinuous first conductors oriented in a first direction, which conductors are interrupted in interconnection zones, and in that at least one second conductor (13; 113) electrically connects the first conductors to one another in the interconnection zones, and in that it is fastened to at least one first electrical conductor and comprises fastening zones in which it is mechanically and electrically connected to a first electrical conductor and non-connected zones in which it is not mechanically fastened to an electrical conductor, so that it is discontinuously connected to the first electrical conductors, and the least one second conductor being a metal strip, such as a copper strip, or a braid, which covers the two ends of a first conductor at a discontinuity in an interconnection zone and which covers a plurality of interconnection zones so as to electrically connect a plurality of first conductors, this at least one metal strip or braid electrically connecting the first conductors to one another in their discontinuous zones.
An orthopaedic surgical instrument assembly comprising: a broach including (i) a tapered outer surface and (ii) a plurality of cutting teeth formed on the tapered outer surface, a broach insert including a tapered outer surface, an adaptor including a base, an attachment device, and a cutting block configured to be coupled to the attachment device, characterised in that the broach further includes a slot defined in the upper end thereof, the broach insert is configured to be positioned in the slot of the broach, and further includes a plurality of cutting teeth formed on the tapered outer surface, the base of the adaptor is configured to be positioned in the slot of the broach in place of the broach insert, the adaptor further includes a shaft extending from the base, and the attachment device includes a passageway defined therein sized to receive the shaft of the adaptor. a broach including (i) a tapered outer surface and (ii) a plurality of cutting teeth formed on the tapered outer surface, a broach insert including a tapered outer surface, an adaptor including a base, an attachment device, and a cutting block configured to be coupled to the attachment device, characterised in that the broach further includes a slot defined in the upper end thereof, the broach insert is configured to be positioned in the slot of the broach, and further includes a plurality of cutting teeth formed on the tapered outer surface, the base of the adaptor is configured to be positioned in the slot of the broach in place of the broach insert, the adaptor further includes a shaft extending from the base, and the attachment device includes a passageway defined therein sized to receive the shaft of the adaptor.
A method for producing an object made from a hardenable aluminium alloy, the method comprising: providing a raw product of the hardenable aluminium alloy, wherein the raw product is a sheet; heating the raw product of the hardenable aluminium alloy to an elevated temperature in order to dissolve precipitates, wherein the raw product of the hardenable aluminium alloy is heated to an elevated temperature with a heating rate of at least 10 K/s; optionally holding the raw product of the hardenable aluminium alloy at the elevated temperature for a predetermined time; rapidly quenching the raw product of the hardenable aluminium alloy to a temperature lower than the elevated temperature in order to maintain at least partly dissolved precipitates within the aluminium alloy; forming the raw product of the hardenable aluminium alloy below a temperature of 0 °C, in particular below -150 °C, to produce the object. providing a raw product of the hardenable aluminium alloy, wherein the raw product is a sheet; heating the raw product of the hardenable aluminium alloy to an elevated temperature in order to dissolve precipitates, wherein the raw product of the hardenable aluminium alloy is heated to an elevated temperature with a heating rate of at least 10 K/s; optionally holding the raw product of the hardenable aluminium alloy at the elevated temperature for a predetermined time; rapidly quenching the raw product of the hardenable aluminium alloy to a temperature lower than the elevated temperature in order to maintain at least partly dissolved precipitates within the aluminium alloy; forming the raw product of the hardenable aluminium alloy below a temperature of 0 °C, in particular below -150 °C, to produce the object.
A pressure-compensated proximity sensor assembly for high-pressure subsea applications, characterized by: a proximity sensor tip assembly (120, 400, 430) including a proximity sensor cap (200, 404) at an end thereof and a sensing element (250, 408) disposed at least partially within the proximity sensor cap (200, 404), the sensing element (250, 408) configured to produce a signal indicative of a distance ("G") between a reference point on the proximity sensor tip assembly (120, 400, 430) and a reference point on a target (14, 176) proximate the proximity sensor cap (200, 404); and a sensor housing (232, 232' 332) connected to the proximity sensor cap (200, 404), the sensor housing (232, 232' 332) defining a fluid reservoir containing a substantially incompressible fluid therein, the fluid reservoir in fluid communication with interior portions of the proximity sensor cap (200, 404) such that at least a portion of an internal pressure on the substantially incompressible fluid within the fluid reservoir is applied to the interior portions of the proximity sensor cap (200, 404); and wherein the sensor housing (232, 232' 332) is configured such that the internal pressure on the sensor housing (232, 232' 332) and the substantially incompressible fluid contained therein increases in response to an increase in an external pressure on the sensor housing (232, 232' 332). a proximity sensor tip assembly (120, 400, 430) including a proximity sensor cap (200, 404) at an end thereof and a sensing element (250, 408) disposed at least partially within the proximity sensor cap (200, 404), the sensing element (250, 408) configured to produce a signal indicative of a distance ("G") between a reference point on the proximity sensor tip assembly (120, 400, 430) and a reference point on a target (14, 176) proximate the proximity sensor cap (200, 404); and a sensor housing (232, 232' 332) connected to the proximity sensor cap (200, 404), the sensor housing (232, 232' 332) defining a fluid reservoir containing a substantially incompressible fluid therein, the fluid reservoir in fluid communication with interior portions of the proximity sensor cap (200, 404) such that at least a portion of an internal pressure on the substantially incompressible fluid within the fluid reservoir is applied to the interior portions of the proximity sensor cap (200, 404); and wherein the sensor housing (232, 232' 332) is configured such that the internal pressure on the sensor housing (232, 232' 332) and the substantially incompressible fluid contained therein increases in response to an increase in an external pressure on the sensor housing (232, 232' 332).