A compound of formula where: R is -CH(R 1)-COOH, where: R 1 is H or a C 1 -C 3 alkyl chain that is optionally substituted by a C 1 -C 3 alkoxy or C 1 -C 3 hydroxyalkoxy group; n is 1 or 2; Z is an amine derivative selected from -N(R 2)(R 3) and -NHR 4; wherein: R 2 is selected from the group consisting of: an aryl ring, a cycloalkyl ring, and a C 1 -C 10 alkyl optionally interrupted by one or more oxygen atoms and/or optionally substituted by one or more hydroxyl groups, or by an aryl or cycloalkyl ring; R 3 is selected from the group consisting of: a C 5 -C 12 hydroxyalkyl comprising at least 2 hydroxyl groups; a C 2 -C 10 hydroxyalkoxyalkylene of formula -(CH 2) r -[(O-(CH 2) r]m(CH 2) s OH; and a group of formula -(CH 2) s CH(R 5)-G; where s is 0, 1 or 2; r is, independently of one another, 1 or 2; m is 1, 2 or 3; and where R 5 is H, or an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the alkylene chain; G is a group selected from -PO(OR 6) 2, -PO(R 7)(OR 6) and -COOH; in which R 6 independently of one another is H or C 1 -C 5 alkyl; R 7 is an aryl or cycloalkyl ring, or C 1 -C 5 alkyl which is optionally substituted by an aryl or cycloalkyl ring; or R 2 and R 3 together with the connecting nitrogen atom form a substituted five- or six-membered saturated ring; R 4 is selected from the group consisting of: a C 5 -C 12 hydroxyalkyl comprising at least 2 hydroxyl groups; a C 2 -C 10 hydroxyalkoxyalkylene of formula -(CH 2) r -[(O-(CH 2) r] m (CH 2) s OH; -(CH 2) m PO(OR 6) 2; -(CH 2) m PO(R 7)(OR 6); and -(CH 2) s CH(R 8)G; where: R 8 is an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the alkylene chain; and m, s, r R 6 and R 7 are as above said, as well as individual diastereoisomers and their racemic mixtures, geometric isomers and solved enantiomers of the same, and the physiologically acceptable salt thereof. R is -CH(R 1)-COOH, where: R 1 is H or a C 1 -C 3 alkyl chain that is optionally substituted by a C 1 -C 3 alkoxy or C 1 -C 3 hydroxyalkoxy group; n is 1 or 2; Z is an amine derivative selected from -N(R 2)(R 3) and -NHR 4; wherein: R 2 is selected from the group consisting of: an aryl ring, a cycloalkyl ring, and a C 1 -C 10 alkyl optionally interrupted by one or more oxygen atoms and/or optionally substituted by one or more hydroxyl groups, or by an aryl or cycloalkyl ring; R 3 is selected from the group consisting of: a C 5 -C 12 hydroxyalkyl comprising at least 2 hydroxyl groups; a C 2 -C 10 hydroxyalkoxyalkylene of formula -(CH 2) r -[(O-(CH 2) r]m(CH 2) s OH; and a group of formula -(CH 2) s CH(R 5)-G; where s is 0, 1 or 2; r is, independently of one another, 1 or 2; m is 1, 2 or 3; and where R 5 is H, or an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the alkylene chain; G is a group selected from -PO(OR 6) 2, -PO(R 7)(OR 6) and -COOH; in which R 6 independently of one another is H or C 1 -C 5 alkyl; R 7 is an aryl or cycloalkyl ring, or C 1 -C 5 alkyl which is optionally substituted by an aryl or cycloalkyl ring; or R 6 independently of one another is H or C 1 -C 5 alkyl; R 7 is an aryl or cycloalkyl ring, or C 1 -C 5 alkyl which is optionally substituted by an aryl or cycloalkyl ring; R 2 and R 3 together with the connecting nitrogen atom form a substituted five- or six-membered saturated ring; R 4 is selected from the group consisting of: a C 5 -C 12 hydroxyalkyl comprising at least 2 hydroxyl groups; a C 2 -C 10 hydroxyalkoxyalkylene of formula -(CH 2) r -[(O-(CH 2) r] m (CH 2) s OH; -(CH 2) m PO(OR 6) 2; -(CH 2) m PO(R 7)(OR 6); and -(CH 2) s CH(R 8)G; where: R 8 is an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the alkylene chain; and m, s, r R 6 and R 7 are as above said,