A turbocharged internal combustion engine, comprising: an engine block with a first end side opposing a second end side; and a two-stage turbocharged system comprising a low-pressure stage turbocharger mounted at the first end side of the engine block and comprising a first turbine (T L) and a first compressor (C L) configured for pre-compressing charge air during operation of the turbocharged internal combustion engine, a high-pressure stage turbocharger mounted at the second end side of the engine block and comprising a second turbine (T H) and a second compressor (C H) configured for compressing the pre-compressed charge air during operation of the turbocharged internal combustion engine, a compressor connection fluidly connecting the first compressor (C L) and the second compressor (C H); a turbine connection fluidly connecting the first turbine (T L) and the second turbine (T H); an SCR catalyst positioned within a catalyst section of the turbine connection; a plurality of cylinders (16A-16F); an exhaust manifold fluidly connecting exhaust outlets of the plurality of cylinders (16A-16F) with an inlet of the second turbine (T H); characterized in that it comprises an urea injection system with an injection inlet configured for injecting a chemical substance for the SCR catalyst through the injection inlet into the turbine connection, wherein the injection inlet is arranged upstream of the catalyst section of the turbine connection; a valve connection connecting the exhaust manifold fluidly with the turbine connection; and a valve arranged within the valve connection configured to control the amount of exhaust gas driving the second turbine (T H). an engine block with a first end side opposing a second end side; and a two-stage turbocharged system comprising a low-pressure stage turbocharger mounted at the first end side of the engine block and comprising a first turbine (T L) and a first compressor (C L) configured for pre-compressing charge air during operation of the turbocharged internal combustion engine, a high-pressure stage turbocharger mounted at the second end side of the engine block and comprising a second turbine (T H) and a second compressor (C H) configured for compressing the pre-compressed charge air during operation of the turbocharged internal combustion engine, a compressor connection fluidly connecting the first compressor (C L) and the second compressor (C H); a turbine connection fluidly connecting the first turbine (T L) and the second turbine (T H); an SCR catalyst positioned within a catalyst section of the turbine connection; a plurality of cylinders (16A-16F); an exhaust manifold fluidly connecting exhaust outlets of the plurality of cylinders (16A-16F) with an inlet of the second turbine (T H); characterized in that it comprises an urea injection system with an injection inlet configured for injecting a chemical substance for the SCR catalyst through the injection inlet into the turbine connection, wherein the injection inlet is arranged upstream of the catalyst section of the turbine connection; a valve connection connecting the exhaust manifold fluidly with the turbine connection; and a valve arranged within the valve connection configured to control the amount of exhaust gas driving the second turbine (T H).