A method for transmitting a Hybrid Automatic Repeat Request, HARQ, failure indication, applied to a process of transmitting data flows of a primary carrier and a secondary carrier on independent transmission bearers of a lub interface/lur interface respectively, comprising: receiving an Enhanced Dedicated Transport Channel, E-DCH, payload from the primary carrier and failing to decode it by a Node B; determining, by the Node B, whether a condition for transmitting an HARQ failure indication is met, if it is met, setting by the Node B an HARQ failure indication data frame on the primary carrier; and transmitting, by the Node B, the HARQ failure indication data frame to a Service Radio Network Controller, SRNC, on a transmission bearer corresponding to the primary carrier; characterized in that, the step of setting an HARQ failure indication data frame on the primary carrier comprises: setting a Connection Frame Number, CFN, domain and a subframe number domain as a CFN and a subframe number when detecting an HARQ failure; if the data frame is of a first type, setting a number domain of Medium Access Control-enhanced sublayer Protocol Data Units, MAC-es PDUs, as 0; if the data frame is of a second type, setting a number domain of Medium Access Control-improved sublayer Protocol Data Units, MAC-is PDUs, as 0; and setting an HARQ retransmission number domain as the number of HARQ retransmissions having happened when an HARQ failure is detected. receiving an Enhanced Dedicated Transport Channel, E-DCH, payload from the primary carrier and failing to decode it by a Node B; determining, by the Node B, whether a condition for transmitting an HARQ failure indication is met, if it is met, setting by the Node B an HARQ failure indication data frame on the primary carrier; and transmitting, by the Node B, the HARQ failure indication data frame to a Service Radio Network Controller, SRNC, on a transmission bearer corresponding to the primary carrier; characterized in that, the step of setting an HARQ failure indication data frame on the primary carrier comprises: setting a Connection Frame Number, CFN, domain and a subframe number domain as a CFN and a subframe number when detecting an HARQ failure; if the data frame is of a first type, setting a number domain of Medium Access Control-enhanced sublayer Protocol Data Units, MAC-es PDUs, as 0; if the data frame is of a second type, setting a number domain of Medium Access Control-improved sublayer Protocol Data Units, MAC-is PDUs, as 0; and setting an HARQ retransmission number domain as the number of HARQ retransmissions having happened when an HARQ failure is detected. setting a Connection Frame Number, CFN, domain and a subframe number domain as a CFN and a subframe number when detecting an HARQ failure; if the data frame is of a first type, setting a number domain of Medium Access Control-enhanced sublayer Protocol Data Units, MAC-es PDUs, as 0; if the data frame is of a second type, setting a number domain of Medium Access Control-improved sublayer Protocol Data Units, MAC-is PDUs, as 0; and setting an HARQ retransmission number domain as the number of HARQ retransmissions having happened when an HARQ failure is detected.