A compound of formula I: wherein: R 1 is -S 2 R a, -C R a, -H, -X, -CN, -C 1 -C 6 substituted or unsubstituted alkyl, or -C 3 -C 6 substituted or unsubstituted cycloalkyl,, -C 1 -C 6 alkoxy, -C 3 -C 6 cycloalkoxy, - NHC R a, -NHC NHR a, -C 2 -C 5 lactam, or -C 1 -C 4 cyclourea; and R 1 is located para or meta to the phenylene moiety; where R 1 is a -C 1 -C 6 substituted alkyl, 1, 2 or 3 of the hydrogen atoms of the alkyl and/or the alkyl chain may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; where R 1 is a -C 3 -C 6 substituted cycloalkyl, 1, 2 or 3 of the hydrogen atoms of the cycloalkyl may be substituted and/or the cycloalkyl ring may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; R 2 is -C 1 -C 4 alkyl, -C 1 -C 4 haloalkyl, or =O; R 3 is -C2-C6 alkyl, or -C 2 -C 6 haloalkyl; R 4 and R 5 are independently selected from -H, -C 1 -C 3 alkyl, or -C 1 -C 3 haloalkyl, or R 4 and R 5 together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl C 3 -C 6 heterocycloalkyl, or C 3 -C 6 cyclohaloalkyl; R 6 is -H, -Y, -CH 3, -CY 3, -CHY 2, -CH 2 Y; each R 7 is independently selected from -H, -X, -CN, -C 1 -C 4 alkyl, -C 1 -C 4 haloalkyl, or - C 1 -C 3 alkoxy; each R 8 is independently selected from -X, -C 1 -C 4 alkyl, or -C 1 -C 4 haloalkyl; R a is -H, -C 1 -C 6 substituted or unsubstituted alkyl, or -NH 2, or -NR 9 R 10; each X is independently selected from -F, -CI, -Br, or -I; R 9 and R 10 are independently selected from -H, -C 1 -C 3 alkyl, or -C 1 -C 3 haloalkyl; or R 9 and R 10 together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl, C 3 -C 6 heterocycloalkyl, or C 3 -C 6 cyclohaloalkyl; Y is -F, -CI, -Br, or -I; m is 0, 1, 2, 3, or 4; and n is 0, 1 or 2, or a pharmaceutically acceptable salt, or stereoisomer thereof. R 1 is -S 2 R a, -C R a, -H, -X, -CN, -C 1 -C 6 substituted or unsubstituted alkyl, or -C 3 -C 6 substituted or unsubstituted cycloalkyl,, -C 1 -C 6 alkoxy, -C 3 -C 6 cycloalkoxy, - NHC R a, -NHC NHR a, -C 2 -C 5 lactam, or -C 1 -C 4 cyclourea; and R 1 is located para or meta to the phenylene moiety; where R 1 is a -C 1 -C 6 substituted alkyl, 1, 2 or 3 of the hydrogen atoms of the alkyl and/or the alkyl chain may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; where R 1 is a -C 3 -C 6 substituted cycloalkyl, 1, 2 or 3 of the hydrogen atoms of the cycloalkyl may be substituted and/or the cycloalkyl ring may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; where R 1 is a -C 1 -C 6 substituted alkyl, 1, 2 or 3 of the hydrogen atoms of the alkyl and/or the alkyl chain may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; where R 1 is a -C 3 -C 6 substituted cycloalkyl, 1, 2 or 3 of the hydrogen atoms of the cycloalkyl may be substituted and/or the cycloalkyl ring may be interrupted by an ether linkage (-O-) or an ester linkage (-C O-); each said substituent independently selected from -OH, -CN, -NH 2, =O, -halo, -CO 2 H, -C 1 -C 6 haloalkyl, -C 1 -C 6 haloalkoxy and-C 2 -C 6 haloalkenyl, -C 1 -C 6 alkylcarboxylic acid; R 2 is -C 1 -C 4 alkyl, -C 1 -C 4 haloalkyl, or =O; R 3 is -C2-C6 alkyl, or -C 2 -C 6 haloalkyl; R 4 and R 5 are independently selected from -H, -C 1 -C 3 alkyl, or -C 1 -C 3 haloalkyl, or R 4 and R 5 together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl C 3 -C 6 heterocycloalkyl, or C 3 -C 6 cyclohaloalkyl; R 6 is -H, -Y, -CH 3, -CY 3, -CHY 2, -CH 2 Y; each R 7 is independently selected from -H, -X, -CN, -C 1 -C 4 alkyl, -C 1 -C 4 haloalkyl, or - C 1 -C 3 alkoxy; each R 8 is independently selected from -X, -C 1 -C 4 alkyl, or -C 1 -C 4 haloalkyl; R a is -H, -C 1 -C 6 substituted or unsubstituted alkyl, or -NH 2, or -NR 9 R 10; each X is independently selected from -F, -CI, -Br, or -I; R 9 and R 10 are independently selected from -H, -C 1 -C 3 alkyl, or -C 1 -C 3 haloalkyl; or R 9 and R 10 together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl, C 3 -C 6 heterocycloalkyl, or C 3 -C 6 cyclohaloalkyl; Y is -F, -CI, -Br, or -I; m is 0, 1, 2, 3, or 4; and n is 0, 1 or 2, or a pharmaceutically acceptable salt, or stereoisomer thereof.