A tissue anomaly detection system, comprising: a probe antenna device structured to radiate a narrowband incident radio-frequency signal at a frequency below 700 MHz to irradiate a tissue in near-field conditions so as to produce a resulting radio-frequency signal; a variable frequency oscillator (E-LS) that operates as an electromagnetic wave source connected to first and second modulating modules (MOD1-MOD2) to provide electromagnetic signals; a controller module configured to control the a variable frequency oscillator (E-LS) that operates as electromagnetic wave source; a receiving device structured to receive the resulting signal and provide corresponding received data; a processing module structured to process the received data to provide an information indicating detection of an anomaly in said tissue; wherein: the probe antenna device has a fixed radiation frequency range and is structured so as that the resulting signal is a scattered signal resulting from a combination of the incident signal and an induced radio-frequency signal produced by the radiated tissue; the probe antenna device includes at least one first transmitting antenna connected to the first modulating module and structured to radiate first electromagnetic waves having a first linear polarization and at least one second transmitting antenna connected to the second modulating module and structured to radiate second electromagnetic waves having a second linear polarization orthogonal to the first polarization; the receiving device includes at least one receiving antenna unit including two receiving antennas (R H1 -R V1) orientated to receive electromagnetic waves according to orthogonal linear polarisation and at least one demodulating module (DEM 11); the processing module is structured to analyse from the resulting data an electrical field power scattering versus frequency pattern and detect said anomaly associated with nulls or minima in said pattern. a probe antenna device structured to radiate a narrowband incident radio-frequency signal at a frequency below 700 MHz to irradiate a tissue in near-field conditions so as to produce a resulting radio-frequency signal; a variable frequency oscillator (E-LS) that operates as an electromagnetic wave source connected to first and second modulating modules (MOD1-MOD2) to provide electromagnetic signals; a controller module configured to control the a variable frequency oscillator (E-LS) that operates as electromagnetic wave source; a receiving device structured to receive the resulting signal and provide corresponding received data; a processing module structured to process the received data to provide an information indicating detection of an anomaly in said tissue; wherein: the probe antenna device has a fixed radiation frequency range and is structured so as that the resulting signal is a scattered signal resulting from a combination of the incident signal and an induced radio-frequency signal produced by the radiated tissue; the probe antenna device includes at least one first transmitting antenna connected to the first modulating module and structured to radiate first electromagnetic waves having a first linear polarization and at least one second transmitting antenna connected to the second modulating module and structured to radiate second electromagnetic waves having a second linear polarization orthogonal to the first polarization; the receiving device includes at least one receiving antenna unit including two receiving antennas (R H1 -R V1) orientated to receive electromagnetic waves according to orthogonal linear polarisation and at least one demodulating module (DEM 11); the processing module is structured to analyse from the resulting data an electrical field power scattering versus frequency pattern and detect said anomaly associated with nulls or minima in said pattern. the probe antenna device has a fixed radiation frequency range and is structured so as that the resulting signal is a scattered signal resulting from a combination of the incident signal and an induced radio-frequency signal produced by the radiated tissue; the probe antenna device includes at least one first transmitting antenna connected to the first modulating module and structured to radiate first electromagnetic waves having a first linear polarization and at least one second transmitting antenna connected to the second modulating module and structured to radiate second electromagnetic waves having a second linear polarization orthogonal to the first polarization; the receiving device includes at least one receiving antenna unit including two receiving antennas (R H1 -R V1) orientated to receive electromagnetic waves according to orthogonal linear polarisation and at least one demodulating module (DEM 11); the processing module is structured to analyse from the resulting data an electrical field power scattering versus frequency pattern and detect said anomaly associated with nulls or minima in said pattern.