A production method of large-thickness Q960E ultra-high strength steel plate, the production method comprising: desulfuration pretreatment of molten iron, converter smelting, LF+RH refining, continuous casting, casting blank stacking and slow cooling, casting blank inspection, casting blank determination, casting blank acceptance, casting blank heating, descaling, rolling, air cooling, flaw detection, shot blasting, quenching, tempering, straightening, cutting and sampling, jet printing of a marker, inspecting and putting in storage, wherein, the ultra-high strength steel comprises the following chemical components by weight percent: 0.14-0.16% of C, 0.2-0.3% of Si, 1.1-1.2% of Mn, ≤0.008% of P, ≤0.0015% of S, 0.4-0.6% of Cr, ≤0.1% of Cu, 0.6-0.8% of Ni, 0.1-0.3% of Mo, 0.02-0.04% of Nb, 0.01-0.02% of Ti, 0.04-0.06% of V, ≤0.0015% of B, 0.025-0.04% of Al, ≤0.61% of Ceq, and the balance of Fe and inevitable impurities; the equivalent (%) of C in the chemical components of the ultra-high strength steel is calculated by a formula as follows: Ceq = C + Mn / 6 + Cr + Mo + V / 5 + Cu + Ni / 15 ≤ 0.61; and wherein, a two-stage rolling process is adopted when the casting blank is rolled, the deformation rate of rolling at a first stage is ≥55%, and the deformation rate of rolling at a second stage is ≥45%; the casting blank is heated: the temperature of a heating section is 1240-1250°C, the temperature of a soaking section is controlled to 1220°C, the tapping temperature is between 1180°C and 1200°C, the in-furnace time is 350-420min, the second-stage initial rolling temperature is ≤1050°C, the thickness of a finished product is 70mm, the thickness of the casting blank to be heated is controlled to ≥133mm, the second-stage final rolling temperature is 850-860°C, and air cooling is carried out after rolling; quenched-tempered heat treatment is carried out: the quenching temperature is controlled to 880-890°C, the temperature-raising rate is 1.5±0.1min/mm, the in-furnace time is 125-135min, the tempering temperature is controlled to 590-600°C, the temperature-raising rate is 2.5±0.1min/mm, the in-furnace time is 220-230min, and slow cooling is carried out to room temperature; and pre-straightening is carried out at 790-830°C firstly when hot rolling straightening is carried out. the ultra-high strength steel comprises the following chemical components by weight percent: 0.14-0.16% of C, 0.2-0.3% of Si, 1.1-1.2% of Mn, ≤0.008% of P, ≤0.0015% of S, 0.4-0.6% of Cr, ≤0.1% of Cu, 0.6-0.8% of Ni, 0.1-0.3% of Mo, 0.02-0.04% of Nb, 0.01-0.02% of Ti, 0.04-0.06% of V, ≤0.0015% of B, 0.025-0.04% of Al, ≤0.61% of Ceq, and the balance of Fe and inevitable impurities; the equivalent (%) of C in the chemical components of the ultra-high strength steel is calculated by a formula as follows: Ceq = C + Mn / 6 + Cr + Mo + V / 5 + Cu + Ni / 15 ≤ 0.61; and wherein, a two-stage rolling process is adopted when the casting blank is rolled, the deformation rate of rolling at a first stage is ≥55%, and the deformation rate of rolling at a second stage is ≥45%; the casting blank is heated: the temperature of a heating section is 1240-1250°C, the temperature of a soaking section is controlled to 1220°C, the tapping temperature is between 1180°C and 1200°C, the in-furnace time is 350-420min, the second-stage initial rolling temperature is ≤1050°C, the thickness of a finished product is 70mm, the thickness of the casting blank to be heated is controlled to ≥133mm, the second-stage final rolling temperature is 850-860°C, and air cooling is carried out after rolling; quenched-tempered heat treatment is carried out: the quenching temperature is controlled to 880-890°C, the temperature-raising rate is 1.5±0.1min/mm, the in-furnace time is 125-135min, the tempering temperature is controlled to 590-600°C, the temperature-raising rate is 2.5±0.1min/mm, the in-furnace time is 220-230min, and slow cooling is carried out to room temperature; and pre-straightening is carried out at 790-830°C firstly when hot rolling straightening is carried out.