mhurhangee/ep-ind-claims huggingface dataset:
A method for screening a compound useful for treating pain, inflammation, or pruritus, comprising the steps of: preparing a cell membrane containing GPR83; bringing a compound assumed to be an antagonist against the function of the hemokinin 1 (HK-1) receptor into contact with the cell membrane; confirming whether the compound binds to GPR83 and thus exhibits antagonist activity; and screening a compound useful for treating pain, inflammation, or pruritus, wherein GPR83 is: (i) a polypeptide consisting of the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20; (ii) a polypeptide comprising the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20, and having HK-1 receptor activity; (iii) a polypeptide consisting of an amino acid sequence that has a deletion, a substitution, and/or an addition of 1 to 10 amino acids with respect to the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity; or (iv) a polypeptide comprising an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity. preparing a cell membrane containing GPR83; bringing a compound assumed to be an antagonist against the function of the hemokinin 1 (HK-1) receptor into contact with the cell membrane; confirming whether the compound binds to GPR83 and thus exhibits antagonist activity; and screening a compound useful for treating pain, inflammation, or pruritus, wherein GPR83 is: (i) a polypeptide consisting of the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20; (ii) a polypeptide comprising the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20, and having HK-1 receptor activity; (iii) a polypeptide consisting of an amino acid sequence that has a deletion, a substitution, and/or an addition of 1 to 10 amino acids with respect to the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity; or (iv) a polypeptide comprising an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity. (i) a polypeptide consisting of the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20; (ii) a polypeptide comprising the amino acid sequence represented by any one of SEQ ID NOS: 17 to 20, and having HK-1 receptor activity; (iii) a polypeptide consisting of an amino acid sequence that has a deletion, a substitution, and/or an addition of 1 to 10 amino acids with respect to the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity; or (iv) a polypeptide comprising an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of any one of the polypeptides (i) to (ii), and having HK-1 receptor activity.
A method for concentrating, separating and/or isolating a plurality of charged analytes contained in a sample by depletion zone isotachophoresis, in an apparatus comprising at least a main separation channel comprising an electrolyte, the channel comprising a downstream end and an upstream end, and a depletion zone formation means placed in or connected to an intermediate region between the upstream end and the downstream end, the method comprising the steps of: (i) introducing the sample into the electrolyte at an upstream channel region adjacent to the upstream end, and (ii) forming and/or maintaining an ion depleted zone in the separation channel and adjacent to the depletion zone formation means at a depletion rate using the depletion zone formation means, and (iii) applying an electric field (Ê1) between the downstream end and the upstream end and applying a downstream fluid flow, thereby causing focussing and separation of the analytes forming respective focused analyte zones in the separation channel and adjacent to the ion depleted zone, and (iv) optionally detecting the position and/or composition of the focused zones, and (v) adjusting depletion rate and optionally fluid flow to move at least one focussed analyte zone in a upstream and/or downstream direction and/or to position the one or more focussed analyte zones at a desired position in the separation channel. (i) introducing the sample into the electrolyte at an upstream channel region adjacent to the upstream end, and (ii) forming and/or maintaining an ion depleted zone in the separation channel and adjacent to the depletion zone formation means at a depletion rate using the depletion zone formation means, and (iii) applying an electric field (Ê1) between the downstream end and the upstream end and applying a downstream fluid flow, thereby causing focussing and separation of the analytes forming respective focused analyte zones in the separation channel and adjacent to the ion depleted zone, and (iv) optionally detecting the position and/or composition of the focused zones, and (v) adjusting depletion rate and optionally fluid flow to move at least one focussed analyte zone in a upstream and/or downstream direction and/or to position the one or more focussed analyte zones at a desired position in the separation channel.
A method for providing highly reactive gas fuel to a combustor, comprising: injecting steam from a heat recovery steam generator into a first fuel distribution manifold to modulate the modified Wobbe index of the fuel, wherein the first fuel distribution manifold is fluidly coupled downstream from a gas fuel supply and upstream from the combustor; mixing the steam with a highly reactive gas fuel from the gas fuel supply within the first fuel distribution manifold to form a first steam and gas fuel mixture; injecting the first steam and gas fuel mixture from the first fuel distribution manifold into a first premix fuel circuit of the combustor; and shutting off the flow of the highly reactive gas fuel and purging at least one of the first fuel distribution manifold, and the first premix fuel circuit with the steam. injecting steam from a heat recovery steam generator into a first fuel distribution manifold to modulate the modified Wobbe index of the fuel, wherein the first fuel distribution manifold is fluidly coupled downstream from a gas fuel supply and upstream from the combustor; mixing the steam with a highly reactive gas fuel from the gas fuel supply within the first fuel distribution manifold to form a first steam and gas fuel mixture; injecting the first steam and gas fuel mixture from the first fuel distribution manifold into a first premix fuel circuit of the combustor; and shutting off the flow of the highly reactive gas fuel and purging at least one of the first fuel distribution manifold, and the first premix fuel circuit with the steam.
A movement system for vehicle trailers characterised in that it comprises: - movement means operatively associable to at least one wheel of said trailer; - at least one reversible connection member to be interposed between the movement means and the respective wheel; said member having: - a first shaft having a first connection joint connected in rotation to the first shaft; - a second shaft keyed to said movement means and having a second connection joint connected in rotation to said second shaft; and - means for moving the second joint to axially slide the second joint along the longitudinal extension of the second shaft between a connection configuration to the first joint in which the movement of the means is transmittable to the wheel and a disconnection configuration from the first joint in which movement is not transmittable, characterized in that the first shaft is to be keyed to a hub of the wheel. - movement means operatively associable to at least one wheel of said trailer; - at least one reversible connection member to be interposed between the movement means and the respective wheel; said member having: - a first shaft having a first connection joint connected in rotation to the first shaft; - a second shaft keyed to said movement means and having a second connection joint connected in rotation to said second shaft; and - means for moving the second joint to axially slide the second joint along the longitudinal extension of the second shaft between a connection configuration to the first joint in which the movement of the means is transmittable to the wheel and a disconnection configuration from the first joint in which movement is not transmittable, characterized in that the first shaft is to be keyed to a hub of the wheel. - a first shaft having a first connection joint connected in rotation to the first shaft; - a second shaft keyed to said movement means and having a second connection joint connected in rotation to said second shaft; and - means for moving the second joint to axially slide the second joint along the longitudinal extension of the second shaft between a connection configuration to the first joint in which the movement of the means is transmittable to the wheel and a disconnection configuration from the first joint in which movement is not transmittable, characterized in that the first shaft is to be keyed to a hub of the wheel.
A signaling device for sensing and indicating the presence of an insult in an absorbent article, the device comprising: a housing; a first non-invasive sensor configured to detect the presence of an insult in the absorbent article; and characterised by a second non-invasive sensor (520; 620; 720) configured to detect the presence of at least one identifiable characteristic on the absorbent article, the presence of the at least one identifiable characteristic permitting the operation of said first non-invasive sensor, wherein the at least one identifiable characteristic is one of: at least one predefined color; one or more UV patterns arranged in an identifiable pattern, the UV patterns configured to fluoresce when illuminated by electromagnetic energy at a particular frequency; and an infrared light reflectance of a material. a housing; a first non-invasive sensor configured to detect the presence of an insult in the absorbent article; and characterised by a second non-invasive sensor (520; 620; 720) configured to detect the presence of at least one identifiable characteristic on the absorbent article, the presence of the at least one identifiable characteristic permitting the operation of said first non-invasive sensor, wherein the at least one identifiable characteristic is one of: at least one predefined color; one or more UV patterns arranged in an identifiable pattern, the UV patterns configured to fluoresce when illuminated by electromagnetic energy at a particular frequency; and an infrared light reflectance of a material. at least one predefined color; one or more UV patterns arranged in an identifiable pattern, the UV patterns configured to fluoresce when illuminated by electromagnetic energy at a particular frequency; and an infrared light reflectance of a material.
A welding-type power supply, comprising: power conversion circuitry configured to convert an input power from a power source to a welding-type output power, wherein the voltage of the input power from the power source is configured to be in a low range or a high range; the power conversion circuitry comprising a pre-regulator circuit configured to produce a pre-regulator output voltage; and characterised in that the power conversion circuitry comprises: control circuitry (30, 300) configured to: determine whether the welding-type power supply is in an idle mode; and in response to determining the welding-type power supply is in the idle mode, control the pre-regulator circuit to provide the pre-regulator output voltage at an idle level voltage, wherein the idle level voltage is at a first magnitude when the voltage of the input power is in the low range, and the idle level voltage is at a second magnitude when the voltage of the input power is in the high range. power conversion circuitry configured to convert an input power from a power source to a welding-type output power, wherein the voltage of the input power from the power source is configured to be in a low range or a high range; the power conversion circuitry comprising a pre-regulator circuit configured to produce a pre-regulator output voltage; and characterised in that the power conversion circuitry comprises: control circuitry (30, 300) configured to: determine whether the welding-type power supply is in an idle mode; and in response to determining the welding-type power supply is in the idle mode, control the pre-regulator circuit to provide the pre-regulator output voltage at an idle level voltage, wherein the idle level voltage is at a first magnitude when the voltage of the input power is in the low range, and the idle level voltage is at a second magnitude when the voltage of the input power is in the high range. determine whether the welding-type power supply is in an idle mode; and in response to determining the welding-type power supply is in the idle mode, control the pre-regulator circuit to provide the pre-regulator output voltage at an idle level voltage, wherein the idle level voltage is at a first magnitude when the voltage of the input power is in the low range, and the idle level voltage is at a second magnitude when the voltage of the input power is in the high range.
A multilayer paper filter module comprising an outer frame and a filter arranged three-dimensionally, and spacers arranged between individual sections of the filter to ensure a distance between facing surfaces of the filter, characterized in that the filter, arranged three-dimensionally, is a multilayer paper filter, which is installed in the frame in the form of a multilayer paper filter sheet folded several times, having spacers situated between individual sections of the sheet, wherein the multilayer paper comprises a plurality of sheets of paper situated one above the other, wherein openings of different sizes are formed in the individual sheets of paper by the fact that each sheet of paper is slit at regular intervals, and the length of each slit differs from one layer to the next layer, wherein each sheet of paper is stretched across the slits thereby created.
A plug-in connector part for an optical and/or electrical plug-in connection, wherein the plug-in connector part has a housing and the housing has a first housing part and at least one second housing part, and the first housing part and the second housing part are in a connected state screwed to one another by means of a detachable screw connection and a fixed toothing is fixed to the first housing part and a locking ring of the plug-in connector part and a pre-tensioning spring of the plug-in connector part are mounted on the second housing part, wherein the locking ring is displaceably mounted on the second housing part in directions parallel to a longitudinal direction of the second housing part and the pre-tensioning spring pre-tensions the locking ring in the direction towards an engagement position and the locking ring engages the fixed toothing in the engagement position, wherein the screw connection is, in the connected state, blocked in the engagement position of the locking ring to prevent unscrewing of the screw connection and wherein the screw connection is, in the connected state, rotatable in a release position of the locking ring, in which the locking ring is lifted from the fixed toothing against the pretensioning of the pre-tensioning spring, to unscrew the screw connection, characterised in that the locking ring has a grip surface, elongate in the longitudinal direction of the second housing part, and counter toothing, with teeth projecting from the grip surface in the direction towards the fixed toothing.
Installation switching device having at least one pole current path, comprising two stationary contact pieces (5, 6) and two moveable contact pieces (8, 9) arranged on a moveable contact link, by means of which contact pieces a pole switch having two contacts and a double break is formed, wherein the contact link is acted upon in the opening direction by a pusher and is acted upon in the closing direction by a contact pressure spring, having an electromagnetic release, whose impact armature in the event of a short circuit both acts upon the contact link in the opening direction via the pusher and unlatches the latching point of a switching mechanism with the result that the switching mechanism is acted upon so as to open the contact link permanently counter to the force of the contact pressure spring via an active lever acting upon the pusher, characterized in that a damping element (30, 30', 30") is arranged in that part of the movement path of the contact link through which said contact link passes once it has been acted upon, and in that the contact link or the pusher is mounted in such a way that it can be operatively connected to the damping element (30, 30', 30") in such a way as to slow down the return movement of the contact link or the pusher.
Earpiece for a hearing instrument, which earpiece comprises a case (5, 25, 6), a receiver and a balloon, wherein the case comprises a proximal case segment (5, 25) and a distal case segment, and wherein the receiver is arranged between the two case segments (5, 25, 6), said two case segments (5, 25, 6) mechanically fixing the receiver and being connected to one another in a sealed manner, characterised in that a sound channel and a compressed-air channel, which are separate from each other, are formed between receiver and case, the wall of each channel being formed both by the receiver and by the case, in that in addition, a sound exit aperture is provided, which is connected to a receiver output aperture of the receiver and to the sound channel, and in that the balloon is connected to the compressed-air channel.
A hydraulic composition comprising an α-hydroxy sulfonic acid or a salt thereof, hydraulic powder and water, the ratio of slag in the hydraulic powder being 60% by mass or more.
An electrically operated aerosol-generating system comprising a device and a removable cartridge, the cartridge comprising an aerosol-forming substrate, an electrically operated vapouriser, and first electrical contacts connected to the vapouriser, the device comprising a main body defining a cavity for receiving the cartridge, an electrical power source, second electrical contacts connected to the electrical power source and a mouthpiece portion, wherein the mouthpiece portion, in a closed position, retains the first electrical contacts on the cartridge in contact with the second electrical contacts on the device, wherein the vapouriser is a heater and wherein the cartridge comprises a liquid storage portion comprising a housing holding a liquid aerosol-forming substrate, the housing having an opening; and a fluid permeable heater comprising a plurality of electrically conductive filaments, wherein the fluid permeable heater extends across the opening of the housing of the liquid storage portion. wherein the vapouriser is a heater and wherein the cartridge comprises a liquid storage portion comprising a housing holding a liquid aerosol-forming substrate, the housing having an opening; and a fluid permeable heater comprising a plurality of electrically conductive filaments, wherein the fluid permeable heater extends across the opening of the housing of the liquid storage portion.
A pneumatic tire (1; 1A; 1B) comprising a carcass extending between bead cores of bead portions via a tread portion and sidewall portions, a belt layer arranged on an outer side in a tire radial direction of the carcass and inside of the tread portion, and a porous noise damper arranged on an inner cavity surface of the tread portion, characterized in that a water absorption rate of the noise damper is in a range of from 10% to 25%, the water absorption rate being calculated by a following formula: water absorption rate % = weight change before and after immersion g / volume at 50 % compression cm 3 × 100
A method for preparing compounds of the general formula wherein R 1 is selected from aryl having 6 to 20 carbon atoms that is unsubstituted or substituted by 1, 2, 3, 4 or 5 substituents selected from C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy, phenyl and benzyl; R 2 is selected from hydrogen and C 1 -C 6 -alkyl; R 3 is selected from hydrogen and C 1 -C 6 -alkyl; comprising the steps of: a) providing at least one compound of the general formula where R 1, R 2 and R 3 have the definitions specified above, b) hydrogenation of the compound in the presence of a hydrogenation catalyst under acidic conditions. R 1 is selected from aryl having 6 to 20 carbon atoms that is unsubstituted or substituted by 1, 2, 3, 4 or 5 substituents selected from C 1 -C 12 -alkyl, C 1 -C 12 -alkoxy, phenyl and benzyl; R 2 is selected from hydrogen and C 1 -C 6 -alkyl; R 3 is selected from hydrogen and C 1 -C 6 -alkyl; a) providing at least one compound of the general formula where R 1, R 2 and R 3 have the definitions specified above, b) hydrogenation of the compound in the presence of a hydrogenation catalyst under acidic conditions.
Method for controlling operation of an electric motor in a height-adjustable furniture arrangement, wherein operation of the electric motor provides a height-adjusting function in the height-adjustable furniture arrangement, wherein the method comprises the steps of: providing, by a power supply unit, an incoming power comprising an incoming current and an incoming voltage connected to a transformation unit; transforming, by means of the transformation unit connected to the electric motor, the incoming current and the incoming voltage to a motor supply current and a motor supply voltage supplied to the electric motor, characterized in that the method comprises the steps of: measuring load on the electric motor by measuring the motor supply current level that the motor demands for providing the height-adjusting function, and when the measured load requires a motor supply current higher than the incoming current for providing the height-adjusting function, transforming the levels of the motor supply current and the motor supply voltage such that the motor supply current is higher than the incoming current and the motor supply voltage is lower than the incoming voltage, by calculating a motor supply voltage level necessary for achieving the measured motor supply current level and transforming the motor supply voltage to the calculated motor supply voltage level, wherein the levels of the motor supply current and the motor supply voltage is set such that the incoming power is not exceeded. providing, by a power supply unit, an incoming power comprising an incoming current and an incoming voltage connected to a transformation unit; transforming, by means of the transformation unit connected to the electric motor, the incoming current and the incoming voltage to a motor supply current and a motor supply voltage supplied to the electric motor, measuring load on the electric motor by measuring the motor supply current level that the motor demands for providing the height-adjusting function, and when the measured load requires a motor supply current higher than the incoming current for providing the height-adjusting function, transforming the levels of the motor supply current and the motor supply voltage such that the motor supply current is higher than the incoming current and the motor supply voltage is lower than the incoming voltage, by calculating a motor supply voltage level necessary for achieving the measured motor supply current level and transforming the motor supply voltage to the calculated motor supply voltage level, wherein the levels of the motor supply current and the motor supply voltage is set such that the incoming power is not exceeded.