A computer-implemented method for determining a hemostatic risk of a subject, the method comprising a comparison of a concentration value of a clotting trigger sufficient to start the clotting process in a subject with at least one reference concentration value of said clotting trigger indicative for a hemostatic risk and/or a hemostatic non-risk (hemostatic stability), said method comprising the steps of: a) providing a first information on the hemostatic condition of said subject, wherein said first information is the concentration values of a plurality of coagulation proteins in a blood sample from said subject, b) determining on the basis of said first information of step (a) a concentration value of a clotting trigger sufficient to start the clotting process in said subject, wherein said clotting trigger is tissue factor, TF, wherein said concentration value of TF sufficient to start the clotting process in the subject is determined by an in silico simulation of the clotting process, in the in silico simulation said first information on the hemostatic condition of said subject is used as input feature, and a second information on the hemostatic condition of said subject in the simulated clotting process is used as output feature, wherein said second information on the hemostatic condition of said subject is the concentration values of an activated coagulation protein at a series of time points of the simulated clotting process which are used as a set of output features, and wherein the in silico simulation simulates the dynamic change in coagulation protein concentrations after exposure to TF, c) comparing said concentration value determined in step (b) with a reference concentration value of said TF representing in healthy reference subjects the minimum concentration for a stable hemostatic condition, and d) determining a high risk of thrombosis for said subject if said concentration value determined in step (b) is lower than said reference concentration value of said TF representing in healthy reference subjects the minimum concentration for a stable hemostatic condition. a) providing a first information on the hemostatic condition of said subject, wherein said first information is the concentration values of a plurality of coagulation proteins in a blood sample from said subject, b) determining on the basis of said first information of step (a) a concentration value of a clotting trigger sufficient to start the clotting process in said subject, wherein said clotting trigger is tissue factor, TF, wherein said concentration value of TF sufficient to start the clotting process in the subject is determined by an in silico simulation of the clotting process, in the in silico simulation said first information on the hemostatic condition of said subject is used as input feature, and a second information on the hemostatic condition of said subject in the simulated clotting process is used as output feature, wherein said second information on the hemostatic condition of said subject is the concentration values of an activated coagulation protein at a series of time points of the simulated clotting process which are used as a set of output features, and wherein the in silico simulation simulates the dynamic change in coagulation protein concentrations after exposure to TF, c) comparing said concentration value determined in step (b) with a reference concentration value of said TF representing in healthy reference subjects the minimum concentration for a stable hemostatic condition, and d) determining a high risk of thrombosis for said subject if said concentration value determined in step (b) is lower than said reference concentration value of said TF representing in healthy reference subjects the minimum concentration for a stable hemostatic condition.