A compound for the therapeutic use in a method for increasing the lifetime of red blood cells (RBCs) in a patient in need thereof comprising contacting blood with an effective amount of a compound of formula or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable composition comprising a compound of formula or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier wherein: W, X, Y and Z are each independently selected from CH or N; Q and Q 1 are each independently selected from a bond or NR b; A is optionally substituted bicyclic aryl or optionally substituted bicyclic heteroaryl; L is a bond, -C -, -(CR c R c) m -, -OC -, -(CR c R c) m -OC -, -(CR c R c) m -C -, - NR b C -, or -NR b C - (wherein the point of the attachment to R 1 is on the left-hand side); R 1 is selected from alkyl, carbocycle, aryl, heteroaryl, and heterocyclyl; each of which is substituted with 0-5 occurrences of R d; each R 3 is independently selected from halo, haloalkyl, alkyl, hydroxyl and -OR a, or two adjacent R 3 taken together with the carbon atoms to which they are attached form an optionally substituted heterocyclyl; each R 4 is independently selected from halo, haloalkyl, alkyl, hydroxyl, =O, -OR a and phenyl, or two R 4 taken together with the carbon atoms to which they are attached form a bridged, fused or spyro-fused carbocycle, an aryl or a heteroaryl; each R a is independently selected from alkyl, acyl, hydroxyalkyl and haloalkyl; each R b is independently selected from hydrogen and alkyl; each R c is independently selected from hydrogen, halo, alkyl, alkoxy and halo alkoxy or two R c taken together with the carbon atoms to which they are attached form an optionally substituted carbocycle; each R d is independently selected from halo, haloalkyl, haloalkoxy, alkyl, alkynyl, nitro, cyano, hydroxyl, -C R a, -OC R a, -C OR a, -SR a, -NR a R b and -OR a, or two R d taken together with the carbon atoms to which they are attached form an optionally substituted heterocyclyl; n is 0, 1, or 2; m is 1, 2 or 3; h is 0, 1 or 2; g is 0, 1 or 2; the sum of g + h is equal to or greater than 2; and p is 1 or 2. W, X, Y and Z are each independently selected from CH or N; Q and Q 1 are each independently selected from a bond or NR b; A is optionally substituted bicyclic aryl or optionally substituted bicyclic heteroaryl; L is a bond, -C -, -(CR c R c) m -, -OC -, -(CR c R c) m -OC -, -(CR c R c) m -C -, - NR b C -, or -NR b C - (wherein the point of the attachment to R 1 is on the left-hand side); R 1 is selected from alkyl, carbocycle, aryl, heteroaryl, and heterocyclyl; each of which is substituted with 0-5 occurrences of R d; each R 3 is independently selected from halo, haloalkyl, alkyl, hydroxyl and -OR a, or two adjacent R 3 taken together with the carbon atoms to which they are attached form an optionally substituted heterocyclyl; each R 4 is independently selected from halo, haloalkyl, alkyl, hydroxyl, =O, -OR a and phenyl, or two R 4 taken together with the carbon atoms to which they are attached form a bridged, fused or spyro-fused carbocycle, an aryl or a heteroaryl; each R a is independently selected from alkyl, acyl, hydroxyalkyl and haloalkyl; each R b is independently selected from hydrogen and alkyl; each R c is independently selected from hydrogen, halo, alkyl, alkoxy and halo alkoxy or two R c taken together with the carbon atoms to which they are attached form an optionally substituted carbocycle; each R d is independently selected from halo, haloalkyl, haloalkoxy, alkyl, alkynyl, nitro, cyano, hydroxyl, -C R a, -OC R a, -C OR a, -SR a, -NR a R b and -OR a, or two R d taken together with the carbon atoms to which they are attached form an optionally substituted heterocyclyl; n is 0, 1, or 2; m is 1, 2 or 3; h is 0, 1 or 2; g is 0, 1 or 2; the sum of g + h is equal to or greater than 2; and p is 1 or 2.