mhurhangee/ep-ind-claims huggingface dataset:
A valve arrangement (1, 101, 201, 301, 401) comprising: a valve inlet (10, 110, 210), a valve outlet (20, 120, 220) arranged downstream of said valve inlet, a first chamber (30, 130, 230, 430) arranged directly downstream of said inlet, and a second chamber (40, 140, 240, 440) arranged between said first chamber and said valve outlet, a measuring nipple (60, 160, 260, 460) comprising a measuring channel (62, 162, 262, 462) for receiving a measuring device, a closing arrangement (70, 170, 270) having open positions and a closed position, wherein said closing arrangement in its closed position is configured to prevent fluid communication between said first chamber and said second chamber via said closing arrangement, and wherein said closing arrangement in its open positions is configured to allow for fluid communication between said first chamber and said second chamber via said closing arrangement, a first passage (64, 164, 264, 464) arranged between said first chamber and said measuring channel without passing said second chamber, said first passage being arranged for enabling measuring of fluid pressure in said first chamber by the measuring device, and a second passage (66, 166, 266, 466) arranged between said second chamber and said measuring channel without passing said first chamber, said second passage being arranged for enabling measuring of fluid pressure in said second chamber by the measuring device, wherein said measuring nipple comprises said first passage and said second passage. a valve inlet (10, 110, 210), a valve outlet (20, 120, 220) arranged downstream of said valve inlet, a first chamber (30, 130, 230, 430) arranged directly downstream of said inlet, and a second chamber (40, 140, 240, 440) arranged between said first chamber and said valve outlet, a measuring nipple (60, 160, 260, 460) comprising a measuring channel (62, 162, 262, 462) for receiving a measuring device, a closing arrangement (70, 170, 270) having open positions and a closed position, wherein said closing arrangement in its closed position is configured to prevent fluid communication between said first chamber and said second chamber via said closing arrangement, and wherein said closing arrangement in its open positions is configured to allow for fluid communication between said first chamber and said second chamber via said closing arrangement, a first passage (64, 164, 264, 464) arranged between said first chamber and said measuring channel without passing said second chamber, said first passage being arranged for enabling measuring of fluid pressure in said first chamber by the measuring device, and a second passage (66, 166, 266, 466) arranged between said second chamber and said measuring channel without passing said first chamber, said second passage being arranged for enabling measuring of fluid pressure in said second chamber by the measuring device, wherein said measuring nipple comprises said first passage and said second passage.
- A method of engineering T-cells, comprising modifying human T-cells by inactivating at least: - a first gene encoding a target for an immunosuppressive agent, wherein said gene encodes CD52 or a glucocorticoid receptor, and - a second gene encoding TCR alpha or TCR beta. - a first gene encoding a target for an immunosuppressive agent, wherein said gene encodes CD52 or a glucocorticoid receptor, and - a second gene encoding TCR alpha or TCR beta.
A method for displaying a user interface on a display of a head worn computer, the method comprising: displaying a first layer of information identifying individual hyperlinks in the user interface on the display of the head worn computer; receiving a directional input from at least one of body movement, eye tracking, or hand gestures; and enabling a spotlight area of the user interface, the spotlight area encompassing a portion of the user interface that is smaller than the entire user interface, the spotlight area (i) highlighting one or more of the individual hyperlinks on the display with a second layer of information, (ii) exploding the hyperlinks within the spotlight area when the hyperlinks are closely packed, and (iii) listing labels corresponding to the hyperlinks around the outside of the spotlight area, the spotlight area being located in the user interface based on the received directional input. displaying a first layer of information identifying individual hyperlinks in the user interface on the display of the head worn computer; receiving a directional input from at least one of body movement, eye tracking, or hand gestures; and enabling a spotlight area of the user interface, the spotlight area encompassing a portion of the user interface that is smaller than the entire user interface, the spotlight area (i) highlighting one or more of the individual hyperlinks on the display with a second layer of information, (ii) exploding the hyperlinks within the spotlight area when the hyperlinks are closely packed, and (iii) listing labels corresponding to the hyperlinks around the outside of the spotlight area, the spotlight area being located in the user interface based on the received directional input.
A printable media comprising: a carrier layer comprising a first surface comprising a first area, a second surface opposite the first surface, and a first rigidity; a fabric layer comprising a third surface, a fourth surface opposite the third surface and comprising a second area, and a second rigidity less than the first rigidity; and, a first adhesive, wherein the fabric layer is secured to the carrier layer by the first adhesive bonding a first portion of the fourth surface to the first surface, characterised in that a second portion of the fourth surface of the fabric layer is adhesively bonded to the second surface of the carrier layer. a carrier layer comprising a first surface comprising a first area, a second surface opposite the first surface, and a first rigidity; a fabric layer comprising a third surface, a fourth surface opposite the third surface and comprising a second area, and a second rigidity less than the first rigidity; and, a first adhesive, wherein the fabric layer is secured to the carrier layer by the first adhesive bonding a first portion of the fourth surface to the first surface, characterised in that a second portion of the fourth surface of the fabric layer is adhesively bonded to the second surface of the carrier layer.
A valve configured to be disposed in a medical barrel for permitting mixing of at least two components within the medical barrel, the valve comprising: a stopper configured to be disposed within the barrel and configured for slidable engagement with an inner surface of the barrel, the stopper being moveable under a distally directed force of a plunger between a first position and a second position, the stopper having a proximal end, a distal end, and a channel extending therebetween; and a stationary body configured to be disposed at least partially within the barrel comprising a base and a stem, the stem comprising a proximal end configured to engage the channel to form a liquid-tight seal with the channel and a port for conducting fluid through the port and the channel, wherein when the stopper is in the first position fluid flow through the channel is prevented by the liquid-tight seal between the proximal end of the stem and the channel, characterized in that the channel includes a proximal end having a first diameter, and a distal end having a second diameter, the first diameter is larger than the second diameter, and movement of the stopper from the first position to the second position brings the proximal end of the stem from the distal end of the channel having the second diameter to the proximal end of the channel having the first diameter to overcome the liquid-tight seal and forms a flow-path through the channel and the port. a stopper configured to be disposed within the barrel and configured for slidable engagement with an inner surface of the barrel, the stopper being moveable under a distally directed force of a plunger between a first position and a second position, the stopper having a proximal end, a distal end, and a channel extending therebetween; and a stationary body configured to be disposed at least partially within the barrel comprising a base and a stem, the stem comprising a proximal end configured to engage the channel to form a liquid-tight seal with the channel and a port for conducting fluid through the port and the channel, wherein when the stopper is in the first position fluid flow through the channel is prevented by the liquid-tight seal between the proximal end of the stem and the channel, characterized in that the channel includes a proximal end having a first diameter, and a distal end having a second diameter, the first diameter is larger than the second diameter, and movement of the stopper from the first position to the second position brings the proximal end of the stem from the distal end of the channel having the second diameter to the proximal end of the channel having the first diameter to overcome the liquid-tight seal and forms a flow-path through the channel and the port.
Optoelectronic thin-film chip comprising - at least one radiation-emitting region in an active zone of a thin-film layer, and - a lens (10, 12) which is arranged downstream of the radiation-emitting region and which is formed by at least a partial region of the thin-film layer, wherein the lateral extent (Φ) of the lens (10, 12) is greater than the lateral extent of the radiation-emitting region (δ), - a distance between the radiation-emitting region and a base point of the lens (10, 12) is between 1 and 25 μm, characterized in that - the thin-film chip comprises a carrier applied to a side of the thin-film layer opposite the lens (10, 12), - at least one current injection region is present, which is arranged between the carrier and the thin-film layer, the lateral extent of the lens (Φ) being greater than the lateral extent of the current injection region (δ), - a depression is introduced in an interface of the thin-film layer which faces the carrier, wherein the depression at least partially surrounds the current injection region and wherein the depression does not cut through the active zone. - at least one radiation-emitting region in an active zone of a thin-film layer, and - a lens (10, 12) which is arranged downstream of the radiation-emitting region and which is formed by at least a partial region of the thin-film layer, wherein the lateral extent (Φ) of the lens (10, 12) is greater than the lateral extent of the radiation-emitting region (δ), - a distance between the radiation-emitting region and a base point of the lens (10, 12) is between 1 and 25 μm, - the thin-film chip comprises a carrier applied to a side of the thin-film layer opposite the lens (10, 12), - at least one current injection region is present, which is arranged between the carrier and the thin-film layer, the lateral extent of the lens (Φ) being greater than the lateral extent of the current injection region (δ), - a depression is introduced in an interface of the thin-film layer which faces the carrier, wherein the depression at least partially surrounds the current injection region and wherein the depression does not cut through the active zone.
Method for the expression and/or production of a polypeptide comprising one or more immunoglobulin single variable domains and comprising a C-terminal extension of maximal 10 amino acid residues in which at least one amino acid residue is a cysteine residue, wherein the one or more immunoglobulin single variable domains are attached to the C-terminal extension, said method comprising the steps of: a) maintaining a Pichia pastoris host under conditions that are such that said Pichia pastoris host expresses and/or produces the polypeptide; b) isolating and/or purifying the secreted polypeptide from the medium; wherein at least 80 % of the polypeptide isolated and/or purified in step b) contains the at least one cysteine residue in the C-terminal extension, as determined by mass spectrometry; and wherein the C-terminal extension is selected from any of SEQ ID NO's: 2-7. a) maintaining a Pichia pastoris host under conditions that are such that said Pichia pastoris host expresses and/or produces the polypeptide; b) isolating and/or purifying the secreted polypeptide from the medium;
Compounds of the formula I in which denotes phenylen or 2,3-dihydro-indol-1,6-diyl, each of which is unsubstituted or monosubstituted by OA, X denotes Hal, Y denotes alkyl having 1, 2, 3 or 4 C atoms, L 1 denotes (CH 2) n NR 1 CO, (CH 2) n, NH(CH 2) n, OCH 2 CHOH, NHCO(CH 2) n, CO(CH 2) n NR 1, CONR 2, (CH 2) n CONR 1, O(CH 2) p CONR 1, NR 1 CONR 3 CHR 4 CONR 1, SO 2 NR 1 (CH 2) p CONR 1 or O(CH 2) p NR 1 CO, L 2 denotes O(CH 2) p, (CH 2) n NR 1 CO, O(CH 2) p NR 1 CO, CHR 5 NR 1 CO or CHR 3 NR 4 CO, R 1 denotes H or methyl, R 2 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, 2,3-dihydro-pyrazolyl, 1,2-dihydro-pyridyl or tetrahydropyranyl, each of which is unsubstituted or mono- or disubstituted by A and/or =O, R 3 and R 4 together denote an alkylene chain having 2, 3 or 4 CH 2 groups, R 5 denotes A or benzyl, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F and/or in which one or two non-adjacent CH and/or CH 2 groups may be replaced by O or N, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2, 3 or 4, p denotes 1, 2, 3 or 4, and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. X denotes Hal, Y denotes alkyl having 1, 2, 3 or 4 C atoms, L 1 denotes (CH 2) n NR 1 CO, (CH 2) n, NH(CH 2) n, OCH 2 CHOH, NHCO(CH 2) n, CO(CH 2) n NR 1, CONR 2, (CH 2) n CONR 1, O(CH 2) p CONR 1, NR 1 CONR 3 CHR 4 CONR 1, SO 2 NR 1 (CH 2) p CONR 1 or O(CH 2) p NR 1 CO, L 2 denotes O(CH 2) p, (CH 2) n NR 1 CO, O(CH 2) p NR 1 CO, CHR 5 NR 1 CO or CHR 3 NR 4 CO, R 1 denotes H or methyl, R 2 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, 2,3-dihydro-pyrazolyl, 1,2-dihydro-pyridyl or tetrahydropyranyl, each of which is unsubstituted or mono- or disubstituted by A and/or =O, R 3 and R 4 together denote an alkylene chain having 2, 3 or 4 CH 2 groups, R 5 denotes A or benzyl, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F and/or in which one or two non-adjacent CH and/or CH 2 groups may be replaced by O or N, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2, 3 or 4, p denotes 1, 2, 3 or 4,
A method for producing a vulcanized rubber composition, comprising: a first kneading step of obtaining a kneaded mixture comprising: a rubber component comprising at least one selected from the group consisting of natural rubbers and synthetic rubbers, wherein the rubber component is capable of undergoing vulcanization, a filler comprising an inorganic filler, and a sulfur-containing silane coupling agent; a second kneading step of adding sulfur and a vulcanization accelerator to the kneaded mixture, followed by kneading, to thereby obtain an unvulcanized rubber composition; and a vulcanization step of vulcanizing the unvulcanized rubber composition to thereby obtain a vulcanized rubber composition having a glass transition temperature of -30°C or more and 0°C or less, wherein at least one selected from the group consisting of compounds represented by formulae,, and below is added, followed by kneading, in the first kneading step: wherein X is an acid that forms a salt together with a guanidine moiety; wherein X is an acid that forms a salt together with a guanidine moiety, R 1 and R 2 are each independently any one selected from the group consisting of a hydrogen atom and an alkyl group, a cycloalkyl group, an aryl group, an alkyl aryl group, and an alkenyl group which have 1 to 18 carbon atoms, these groups each optionally having one or more substituents containing at least one selected from the group consisting of a sulfur atom, a nitrogen atom, and an oxygen atom; and wherein X is an acid that forms a salt together with a guanidine moiety. a first kneading step of obtaining a kneaded mixture comprising: a rubber component comprising at least one selected from the group consisting of natural rubbers and synthetic rubbers, wherein the rubber component is capable of undergoing vulcanization, a filler comprising an inorganic filler, and a sulfur-containing silane coupling agent; a second kneading step of adding sulfur and a vulcanization accelerator to the kneaded mixture, followed by kneading, to thereby obtain an unvulcanized rubber composition; and a vulcanization step of vulcanizing the unvulcanized rubber composition to thereby obtain a vulcanized rubber composition having a glass transition temperature of -30°C or more and 0°C or less, wherein at least one selected from the group consisting of compounds represented by formulae,, and below is added, followed by kneading, in the first kneading step: wherein X is an acid that forms a salt together with a guanidine moiety; wherein X is an acid that forms a salt together with a guanidine moiety, R 1 and R 2 are each independently any one selected from the group consisting of a hydrogen atom and an alkyl group, a cycloalkyl group, an aryl group, an alkyl aryl group, and an alkenyl group which have 1 to 18 carbon atoms, these groups each optionally having one or more substituents containing at least one selected from the group consisting of a sulfur atom, a nitrogen atom, and an oxygen atom; and wherein X is an acid that forms a salt together with a guanidine moiety.
A method of transmitting Channel Status Information, CSI, at a user equipment in a wireless communication system, the method comprising: receiving control information including a Coordinated Multi-Point, CoMP, CSI request field, wherein a bit size of the CoMP CSI request field is set to 2 bits, and wherein a serving cell and at least one coordinating cell exist when a CoMP system is applied, determining a CoMP CSI report type for the CSI based on a value of the CoMP CSI request field, wherein one value of the CoMP CSI request field indicates that no aperiodic report is triggered, wherein the CoMP CSI report type is distinguished by CSI report contents with reference to a report target, and wherein the CoMP CSI report type comprises a first CoMP report type being an aperiodic non-CoMP CSI report having content for the serving cell, a second CoMP report type being an aperiodic CSI report having content for the at least one coordinating cell and a third CoMP report type being an aperiodic CSI report having content for the serving and the at least one coordinating cell, and transmitting the CSI corresponding to the determined CSI report type to a base station via uplink data channel. receiving control information including a Coordinated Multi-Point, CoMP, CSI request field, wherein a bit size of the CoMP CSI request field is set to 2 bits, and wherein a serving cell and at least one coordinating cell exist when a CoMP system is applied, determining a CoMP CSI report type for the CSI based on a value of the CoMP CSI request field, wherein one value of the CoMP CSI request field indicates that no aperiodic report is triggered, wherein the CoMP CSI report type is distinguished by CSI report contents with reference to a report target, and wherein the CoMP CSI report type comprises a first CoMP report type being an aperiodic non-CoMP CSI report having content for the serving cell, a second CoMP report type being an aperiodic CSI report having content for the at least one coordinating cell and a third CoMP report type being an aperiodic CSI report having content for the serving and the at least one coordinating cell, and transmitting the CSI corresponding to the determined CSI report type to a base station via uplink data channel.
Tilting segment for being arranged in a spaced apart manner with respect to a bearing axis for supporting shafts in plain bearings with a supporting face and a bearing face which is arranged opposite the supporting face, the supporting face being delimited in the axial direction by two side faces (3, 4) and transversely with respect to this, in particular in the installed position, in the circumferential direction by an inlet edge and an outlet edge, structures which promote the lubricant and coolant discharge being provided on the outlet edge, characterized in that the structures which promote the lubricant and coolant discharge on the outlet edge comprise cut-outs which are arranged on the outlet edge, are open at the edges, and are arranged so as to be spaced apart from one another as viewed in the axial direction of the tilting segment.
A method for producing soluble di-chain BoNT/A protein, said method comprising: a) providing a soluble single-chain BoNT/A protein; b) contacting said BoNT/A protein with endoproteinase Lys-C (Lys-C) in solution; and c) separating the soluble BoNT/A protein from the Lys-C by contacting the solution containing soluble BoNT/A protein and Lys-C with a hydrophobic surface, wherein the soluble BoNT/A protein binds with preference to the hydrophobic surface. a) providing a soluble single-chain BoNT/A protein; b) contacting said BoNT/A protein with endoproteinase Lys-C (Lys-C) in solution; and c) separating the soluble BoNT/A protein from the Lys-C by contacting the solution containing soluble BoNT/A protein and Lys-C with a hydrophobic surface, wherein the soluble BoNT/A protein binds with preference to the hydrophobic surface.
A surgical device comprising: a handle assembly including: a power source; a motor coupled to the power source; and a controller configured to control the motor; an adapter assembly configured to selectively couple to the handle assembly, wherein the adapter assembly includes a strain gauge configured to measure strain; a reload configured to selectively couple to a distal portion of the adapter assembly, the reload including a plurality of fasteners ("S"); and an anvil assembly selectively couplable to the distal portion of the adapter assembly, the anvil assembly being movable relative to the reload, wherein the controller is configured to control the motor to move the anvil thereby compressing tissue between the anvil assembly and the reload at a first speed for a first segment and at a second speed for a second segment, the second speed being slower than the first speed, and characterized in that the strain gauge is configured to measure strain caused by the compression of tissue between the anvil assembly and the reload, and in that the controller is further configured to determine whether the anvil assembly is decoupled from the adapter assembly based on the strain measured by the strain gauge during the second segment. a handle assembly including: a power source; a motor coupled to the power source; and a controller configured to control the motor; a power source; a motor coupled to the power source; and a controller configured to control the motor; an adapter assembly configured to selectively couple to the handle assembly, wherein the adapter assembly includes a strain gauge configured to measure strain; a reload configured to selectively couple to a distal portion of the adapter assembly, the reload including a plurality of fasteners ("S"); and an anvil assembly selectively couplable to the distal portion of the adapter assembly, the anvil assembly being movable relative to the reload, wherein the controller is configured to control the motor to move the anvil thereby compressing tissue between the anvil assembly and the reload at a first speed for a first segment and at a second speed for a second segment, the second speed being slower than the first speed, and characterized in that the strain gauge is configured to measure strain caused by the compression of tissue between the anvil assembly and the reload, and in that the controller is further configured to determine whether the anvil assembly is decoupled from the adapter assembly based on the strain measured by the strain gauge during the second segment.