A liquid chromatography system comprising - an LC switching valve comprising a sample input port, an aspiration pump port, a needle seat port, a waste port, an LC pump port and an LC column port, - a sample aspiration needle fluidically connected to the sample input port via a sample receiving conduit, - an aspiration pump fluidically connected to the aspiration pump port for aspirating a sample via the sample aspiration needle when the sample aspiration needle is inserted into a sample container and when the aspiration pump port is connected to the sample input port, - a needle seat fluidically connected to the needle seat port via a needle seat conduit, - an LC column fluidically connected to the LC column port, - an LC pump fluidically connected to the LC pump port, - wherein the LC system is configured for injecting by the LC pump at least part of the sample aspirated in the sample receiving conduit into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port, characterized in that the sample input port is fluidically connected to the aspiration pump port and the needle seat port is fluidically connected to the waste port when the LC pump port is fluidically connected to the LC column port for liquid chromatography of the sample injected in the column and for parallel washing of the sample receiving conduit, the sample aspiration needle and the needle seat conduit by pumping a wash liquid by a wash pump or by the aspiration pump. - an LC switching valve comprising a sample input port, an aspiration pump port, a needle seat port, a waste port, an LC pump port and an LC column port, - a sample aspiration needle fluidically connected to the sample input port via a sample receiving conduit, - an aspiration pump fluidically connected to the aspiration pump port for aspirating a sample via the sample aspiration needle when the sample aspiration needle is inserted into a sample container and when the aspiration pump port is connected to the sample input port, - a needle seat fluidically connected to the needle seat port via a needle seat conduit, - an LC column fluidically connected to the LC column port, - an LC pump fluidically connected to the LC pump port, - wherein the LC system is configured for injecting by the LC pump at least part of the sample aspirated in the sample receiving conduit into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port, characterized in that the sample input port is fluidically connected to the aspiration pump port and the needle seat port is fluidically connected to the waste port when the LC pump port is fluidically connected to the LC column port for liquid chromatography of the sample injected in the column and for parallel washing of the sample receiving conduit, the sample aspiration needle and the needle seat conduit by pumping a wash liquid by a wash pump or by the aspiration pump.