A device for deploying a suture clip onto a suture, comprising: a proximal handle portion comprising an actuation mechanism (106, 108); a shaft portion having an inner lumen, a proximal end portion coupled to the actuation mechanism (106,108), a distal end portion having a distal opening in communication with the inner lumen, and an intermediate portion having a radial opening (124, 134) in communication with the inner lumen, and a generally tubular main shaft, wherein the main shaft is configured to hold one or more annular suture clips loaded on the distal end portion of the main shaft, and wherein the main shaft is also configured to receive at least one suture extending through the distal opening, through the inner lumen, and through the radial opening (124, 134); and a pusher positioned at least partially around the main shaft and coupled to the actuation mechanism (106, 108) independently of the main shaft, the pusher configured to be positioned proximal to the one or more suture clips when the one or more suture clips are loaded on the main shaft; wherein the actuation mechanism (106, 108) is configured to cause the main shaft to move proximally relative to the handle portion, the pusher, and the one or more suture clips loaded on the main shaft, such that a distal-most one of the one or more suture slips slides distally off of a distal end of the main shaft and onto a suture extending through the distal opening of the main shaft; characterized in that the handle portion comprises a vacuum source that is fluidly coupled to the inner lumen of the shaft portion to assist in drawing a suture through the distal opening and into the inner lumen. a proximal handle portion comprising an actuation mechanism (106, 108); a shaft portion having an inner lumen, a proximal end portion coupled to the actuation mechanism (106,108), a distal end portion having a distal opening in communication with the inner lumen, and an intermediate portion having a radial opening (124, 134) in communication with the inner lumen, and a generally tubular main shaft, wherein the main shaft is configured to hold one or more annular suture clips loaded on the distal end portion of the main shaft, and wherein the main shaft is also configured to receive at least one suture extending through the distal opening, through the inner lumen, and through the radial opening (124, 134); and a pusher positioned at least partially around the main shaft and coupled to the actuation mechanism (106, 108) independently of the main shaft, the pusher configured to be positioned proximal to the one or more suture clips when the one or more suture clips are loaded on the main shaft; wherein the actuation mechanism (106, 108) is configured to cause the main shaft to move proximally relative to the handle portion, the pusher, and the one or more suture clips loaded on the main shaft, such that a distal-most one of the one or more suture slips slides distally off of a distal end of the main shaft and onto a suture extending through the distal opening of the main shaft; characterized in that the handle portion comprises a vacuum source that is fluidly coupled to the inner lumen of the shaft portion to assist in drawing a suture through the distal opening and into the inner lumen.