A compound of formula: wherein: X is -CH 2 -, -CH -, -CH(OR')- or -C(R'R")-, wherein: R' is C 1 -C 6 alkyl and R" is hydrogen; Ar is phenyl, pyrazolyl or pyridyl, optionally substituted with one or more substituents independently selected from halogen, nitro, COR4, NR5R6, OR7, NHSO 2 R10, an optionally further substituted straight or branched C 1 -C 6 alkyl, and heterocyclyl; wherein: R4 is NRSR6 or an optionally further substituted heterocyclyl; R5 and R6 are independently hydrogen, R8R9N-C 2 -C 6 alkyl, R8O-C 2 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, phenyl, or, R5 and R6, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group; R7 is an optionally further substituted straight or branched C 1 -C 6 alkyl, or heterocyclyl; R8 and R9 are independently an optionally further substituted straight or branched C 1 -C 6 alkyl; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl; R is an optionally substituted phenyl or pyridyl; R1, R2 and R3 are hydrogens; or isomers, tautomers, or pharmaceutically acceptable salts thereof. X is -CH 2 -, -CH -, -CH(OR')- or -C(R'R")-, wherein: R' is C 1 -C 6 alkyl and R" is hydrogen; R' is C 1 -C 6 alkyl and R" is hydrogen; Ar is phenyl, pyrazolyl or pyridyl, optionally substituted with one or more substituents independently selected from halogen, nitro, COR4, NR5R6, OR7, NHSO 2 R10, an optionally further substituted straight or branched C 1 -C 6 alkyl, and heterocyclyl; wherein: R4 is NRSR6 or an optionally further substituted heterocyclyl; R5 and R6 are independently hydrogen, R8R9N-C 2 -C 6 alkyl, R8O-C 2 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, phenyl, or, R5 and R6, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group; R7 is an optionally further substituted straight or branched C 1 -C 6 alkyl, or heterocyclyl; R8 and R9 are independently an optionally further substituted straight or branched C 1 -C 6 alkyl; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl; R is an optionally substituted phenyl or pyridyl; R1, R2 and R3 are hydrogens; or isomers, tautomers, or pharmaceutically acceptable salts thereof. R4 is NRSR6 or an optionally further substituted heterocyclyl; R5 and R6 are independently hydrogen, R8R9N-C 2 -C 6 alkyl, R8O-C 2 -C 6 alkyl, an optionally further substituted straight or branched C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, heterocyclyl, phenyl, or, R5 and R6, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group; R7 is an optionally further substituted straight or branched C 1 -C 6 alkyl, or heterocyclyl; R8 and R9 are independently an optionally further substituted straight or branched C 1 -C 6 alkyl; R10 is an optionally further substituted straight or branched C 1 -C 6 alkyl; R is an optionally substituted phenyl or pyridyl; R1, R2 and R3 are hydrogens; or isomers, tautomers, or pharmaceutically acceptable salts thereof.