Tubular connection device comprising: • a female connector, into which a male end piece provided with an annular groove is intended to be inserted, the female connector being provided with two lateral slits which are symmetrical with respect to a radial axis; • a U-shaped locking clip, which comprises a head and two branches and straddles the female connector, each branch extending into a lateral slit and ending with a foot; • two lateral guide systems, which are symmetrical with respect to the radial axis and cooperate with the feet of the clip in order to keep it in a raised position of disconnection from the male end piece or in a pressed-in position for locking the male end piece in the female connector, each guide system comprising: o a notch, which is formed in the female connector adjacent to the lateral slit; o a plate, which delimits a lower edge of the notch and on which the foot rests in order to keep the clip in an intermediate position between the raised position and the pressed-in position in the absence of a male end piece; • a ring, which is arranged against an inner wall of the female connector; the device being characterized in that each guide system further comprises a lug, which is arranged on a flexible tab carried by the ring and is intended to at least partly fill the notch and the plate when the male end piece is inserted into the connector, its annular groove being intended to be opposite the lateral slits to allow the clip to pass into a pressed-in position or into a raised position. • a female connector, into which a male end piece provided with an annular groove is intended to be inserted, the female connector being provided with two lateral slits which are symmetrical with respect to a radial axis; • a U-shaped locking clip, which comprises a head and two branches and straddles the female connector, each branch extending into a lateral slit and ending with a foot; • two lateral guide systems, which are symmetrical with respect to the radial axis and cooperate with the feet of the clip in order to keep it in a raised position of disconnection from the male end piece or in a pressed-in position for locking the male end piece in the female connector, each guide system comprising: o a notch, which is formed in the female connector adjacent to the lateral slit; o a plate, which delimits a lower edge of the notch and on which the foot rests in order to keep the clip in an intermediate position between the raised position and the pressed-in position in the absence of a male end piece; o a notch, which is formed in the female connector adjacent to the lateral slit; o a plate, which delimits a lower edge of the notch and on which the foot rests in order to keep the clip in an intermediate position between the raised position and the pressed-in position in the absence of a male end piece; • a ring, which is arranged against an inner wall of the female connector; the device being characterized in that each guide system further comprises a lug, which is arranged on a flexible tab carried by the ring and is intended to at least partly fill the notch and the plate when the male end piece is inserted into the connector, its annular groove being intended to be opposite the lateral slits to allow the clip to pass into a pressed-in position or into a raised position.