A fecal collection system (100; 600), comprising: a user interface assembly (110; 1210; 1310), comprising: a user interface (116; 1016; 1116; 1216; 1316) having a proximal side and a distal side, wherein the proximal side is configured to couple to skin of a user, and an applicator (118; 1218; 1318) coupled to the distal side of the user interface (116; 1016; 1116; 1216; 1316), wherein the applicator (118; 1218; 1318) is removable from the user interface (116; 1016; 1116; 1216; 1316) while the user interface (116; 1016; 1116; 1216; 1316) is coupled to the user, said applicator (118; 1218; 1318) comprising a first lateral portion (318A; 618A; 718A) and a second lateral portion (318B; 618B; 718B); a drainage conduit extending between a proximal end and a distal end, wherein the proximal end is configured to couple to the distal side of the user interface (116; 1016; 1116; 1216; 1316), wherein the drainage conduit defines a lumen configured to guide feces from the proximal end to the distal end; a collection reservoir coupled to the distal end of the drainage conduit, characterized in that the applicator (118; 1218; 1318) further comprises a hinge portion (318C; 718C) between the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B), wherein the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B) are configured to move about the hinge portion (318C; 718C) between an extended state and a folded state, wherein the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B) are configured to decouple from each other to remove the applicator (118; 1218; 1318) from the user interface (116; 1016; 1116; 1216; 1316), and wherein the drainage conduit extends through an aperture (344; 754; 1219; 1319) in the applicator (118; 1218; 1318). a user interface assembly (110; 1210; 1310), comprising: a user interface (116; 1016; 1116; 1216; 1316) having a proximal side and a distal side, wherein the proximal side is configured to couple to skin of a user, and an applicator (118; 1218; 1318) coupled to the distal side of the user interface (116; 1016; 1116; 1216; 1316), wherein the applicator (118; 1218; 1318) is removable from the user interface (116; 1016; 1116; 1216; 1316) while the user interface (116; 1016; 1116; 1216; 1316) is coupled to the user, said applicator (118; 1218; 1318) comprising a first lateral portion (318A; 618A; 718A) and a second lateral portion (318B; 618B; 718B); a user interface (116; 1016; 1116; 1216; 1316) having a proximal side and a distal side, wherein the proximal side is configured to couple to skin of a user, and an applicator (118; 1218; 1318) coupled to the distal side of the user interface (116; 1016; 1116; 1216; 1316), wherein the applicator (118; 1218; 1318) is removable from the user interface (116; 1016; 1116; 1216; 1316) while the user interface (116; 1016; 1116; 1216; 1316) is coupled to the user, said applicator (118; 1218; 1318) a drainage conduit extending between a proximal end and a distal end, wherein the proximal end is configured to couple to the distal side of the user interface (116; 1016; 1116; 1216; 1316), wherein the drainage conduit defines a lumen configured to guide feces from the proximal end to the distal end; a collection reservoir coupled to the distal end of the drainage conduit, characterized in that the applicator (118; 1218; 1318) further comprises a hinge portion (318C; 718C) between the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B), wherein the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B) are configured to move about the hinge portion (318C; 718C) between an extended state and a folded state, wherein the first lateral portion (318A; 618A; 718A) and the second lateral portion (318B; 618B; 718B) are configured to decouple from each other to remove the applicator (118; 1218; 1318) from the user interface (116; 1016; 1116; 1216; 1316), and wherein the drainage conduit extends through an aperture (344; 754; 1219; 1319) in the applicator (118; 1218; 1318).