A system comprising: an elongate tubular support having a proximal end and a distal end, the tubular support configured for delivery into an opening within an anatomical wall; an anchor assembly configured to be secured to the anatomical wall adjacent the opening, wherein the elongate tubular support is positionable in a first position within the anchor assembly wherein the proximal end of the tubular support is proximal to the anchor assembly and the distal end of the tubular support is distal to the anchor assembly; and a cover of bio-compatible material connected to the anchor assembly and configured to extend distally from the anchor assembly to cover at least a portion of the tubular support when the tubular support is in the first position, wherein a distal end of the cover is attached at a position along the external surface of the tubular support or when the tubular support is in its first position, the cover extends to the distal end of the tubular support and is then inverted to extend within a lumen of the tubular support, and the distal end of the cover is attached at a position along an internal surface of the tubular support; wherein the tubular support is moveable from the first position to a second position, wherein in the second position the distal end of the tubular support is proximal to the anchor assembly, and movement of the tubular support from the first position to the second position draws the cover material inside-out such that the cover material extends proximally from the anchor assembly, characterized in that the anchor assembly is configured to be secured to the anatomical wall adjacent the opening for sealing the opening and comprises a plurality of proximal anchors and a plurality of distal anchors, the proximal and distal anchors (16b, 16a) being foldable towards the tubular support in a first delivery position and being expandable radially outwardly away from the tubular support in a second wall engagement position. an elongate tubular support having a proximal end and a distal end, the tubular support configured for delivery into an opening within an anatomical wall; an anchor assembly configured to be secured to the anatomical wall adjacent the opening, wherein the elongate tubular support is positionable in a first position within the anchor assembly wherein the proximal end of the tubular support is proximal to the anchor assembly and the distal end of the tubular support is distal to the anchor assembly; and a cover of bio-compatible material connected to the anchor assembly and configured to extend distally from the anchor assembly to cover at least a portion of the tubular support when the tubular support is in the first position, wherein a distal end of the cover is attached at a position along the external surface of the tubular support or when the tubular support is in its first position, the cover extends to the distal end of the tubular support and is then inverted to extend within a lumen of the tubular support, and the distal end of the cover is attached at a position along an internal surface of the tubular support; wherein the tubular support is moveable from the first position to a second position, wherein in the second position the distal end of the tubular support is proximal to the anchor assembly, and movement of the tubular support from the first position to the second position draws the cover material inside-out such that the cover material extends proximally from the anchor assembly, characterized in that the anchor assembly is configured to be secured to the anatomical wall adjacent the opening for sealing the opening and comprises a plurality of proximal anchors and a plurality of distal anchors, the proximal and distal anchors (16b, 16a) being foldable towards the tubular support in a first delivery position and being expandable radially outwardly away from the tubular support in a second wall engagement position.