mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method to predict responsiveness of a patient, with cancer, to a therapy, said method comprising detecting the relative amount of one or several MDM2 protein expressing cell types in a sample obtained from said cancer patient prior to treatment and using said relative amount, or percentage (%), of cells expressing MDM2 protein as a biomarker for predicting said patient's response to treatment with a medicament, wherein the medicament comprises a compound acting as inhibitor of the MDM2-p53 interaction, and wherein said MDM2 protein expressing cell type, or biomarker, is selected from the group consisting of CD45dim cells, CD117+ (c-kit) or CD34+ stem cells, or combinational subsets thereof, and wherein said inhibitor of the MDM2-p53 interaction is selected from the compounds: 4-{[2R,3S,4R,5S)-4-(4-Cholor-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid of the formula and 4-{[(2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid 1-mPEG-carbonyloxy-ethyl ester (mPEG, average MW, ∼2000) of the formula
Welding method for implementing and monitoring a welding process with a welding rod that melts in an arc, which is supplied with power from at least one controlled power source, wherein the power source and a feeding device for the welding rod are controlled by means of a control device, and wherein at least one control variable is measured or calculated during the welding process from characteristic variables of the arc, such as welding current, welding voltage or resistance, and different welding parameters or values for the control variable are stored in a memory during the welding process, characterised in that a first and a second time interval with different durations and a scanning rate are set in order to determine the values of the characteristic variable, and the values of the characteristic variable are stored with every scan, after which, at an instant of time, a first mean value and a second mean value are calculated by the control device as the control variable from the stored values of the characteristic variable, which lie in earlier time intervals (101, 102) relative to the instant, whereupon an upper and a lower threshold value (104, 105) are calculated from the first mean value of the first time interval, and whereupon the control variable is compared with the upper and with the lower threshold value (104, 105).
A dual-connectivity, DC, establishment method, which is applied to a first DC architecture, the first DC architecture comprising a Master Node, MN, and a Secondary Node, SN, wherein the SN comprises a Central Unit, CU, and a Distributed Unit, DU; the CU comprises a Control Plane functional entity, CP, and a User Plane functional entity, UP; and, the DC establishment method comprises: receiving, by the CP of the SN, SN-CP, a first SN setup request message transmitted by the MN; transmitting, by the SN-CP, a first resource setup request message to the UP of the SN, SN-UP, according to the first SN setup request message; receiving, by the SN-CP, a first resource setup response message transmitted by the SN-UP; transmitting, by the SN-CP, a first bearer setup request message to the DU of the SN, SN-DU; and receiving, by the SN-CP, a first bearer setup response message transmitted by the SN-DU; wherein the first resource setup request message comprises at least one of: an identifier corresponding to a user equipment, UE, security information of a packet data convergence protocol, PDCP, transport layer information for uplink data, or PDCP configuration information; and wherein the transport layer information for uplink data includes a transport layer address and a tunnel endpoint identifier, TEID. receiving, by the CP of the SN, SN-CP, a first SN setup request message transmitted by the MN; transmitting, by the SN-CP, a first resource setup request message to the UP of the SN, SN-UP, according to the first SN setup request message; receiving, by the SN-CP, a first resource setup response message transmitted by the SN-UP; transmitting, by the SN-CP, a first bearer setup request message to the DU of the SN, SN-DU; and receiving, by the SN-CP, a first bearer setup response message transmitted by the SN-DU; wherein the first resource setup request message comprises at least one of: an identifier corresponding to a user equipment, UE, security information of a packet data convergence protocol, PDCP, transport layer information for uplink data, or PDCP configuration information; and wherein the transport layer information for uplink data includes a transport layer address and a tunnel endpoint identifier, TEID.
A method of preparing human primary T-cell(s) for immunotherapy comprising: (a) providing human T-cells, from a primary cell culture or from a blood sample; (b) genetically modifying said T-cells by introducing into said T-cells rare-cutting endonucleases able to selectively inactivate by DNA cleavage at least two genes: - one gene encoding the immune checkpoint protein PD1, and - one gene encoding TCR alpha orTCR beta, and (c) expanding said cells, wherein said method further comprises introducing into said T-cells a chimeric antigen receptor directed against CD19 antigen. (a) providing human T-cells, from a primary cell culture or from a blood sample; (b) genetically modifying said T-cells by introducing into said T-cells rare-cutting endonucleases able to selectively inactivate by DNA cleavage at least two genes: - one gene encoding the immune checkpoint protein PD1, and - one gene encoding TCR alpha orTCR beta, and - one gene encoding the immune checkpoint protein PD1, and - one gene encoding TCR alpha orTCR beta, and (c) expanding said cells,
A method comprising: receiving encoded data in a bitstream for a video sequence, wherein the bitstream includes one or more parameter sets included in metadata, the metadata including sequence parameter set, SPS, metadata and picture parameter set, PPS, metadata; parsing the one or more parameter sets to determine whether arbitrary slice ordering, ASO, or flexible macroblock ordering, FMO, are used for video encoding, the parsing including parsing the SPS metadata and finding that the bitstream is in baseline profile, not compatible with main profile, and parsing the PPS metadata and finding out whether the bitstream really uses ASO and FMO; and if ASO or FMO are used, forwarding the encoded data to a first decoder engine capable of decoding a video sequence of baseline, main and higher profiles; if the ASO or FMO are not used, forwarding the encoded data to a second decoder engine, different than the first decoder engine, capable of decoding main profile and higher profiles. receiving encoded data in a bitstream for a video sequence, wherein the bitstream includes one or more parameter sets included in metadata, the metadata including sequence parameter set, SPS, metadata and picture parameter set, PPS, metadata; parsing the one or more parameter sets to determine whether arbitrary slice ordering, ASO, or flexible macroblock ordering, FMO, are used for video encoding, the parsing including parsing the SPS metadata and finding that the bitstream is in baseline profile, not compatible with main profile, and parsing the PPS metadata and finding out whether the bitstream really uses ASO and FMO; and if ASO or FMO are used, forwarding the encoded data to a first decoder engine capable of decoding a video sequence of baseline, main and higher profiles; if the ASO or FMO are not used, forwarding the encoded data to a second decoder engine, different than the first decoder engine, capable of decoding main profile and higher profiles.
A transmission apparatus comprising: a transmission signal generator (700, 1512) which, in operation, generates a transmission signal having an aggregate physical layer protocol data unit (aggregate PPDU); and a transmitter which, in operation, transmits the generated transmission signal, characterized in that the aggregate PPDU includes a first PPDU and at least one additional PPDU (1020, 1030, 1040), the first PPDU comprising a legacy preamble (1001, 1003), a legacy header, a non-legacy header, a non-legacy preamble (1007, 1009), and a data field and each of the at least one additional PPDU (1020, 1030, 1040) comprising a non-legacy header (1022, 1042) and a data field (1024, 1034, 1044), the legacy preamble (1001, 1003), the legacy header and the non-legacy headers (1012, 1022, 1042) are transmitted using a standard bandwidth, the non-legacy preamble (1007, 1009) and the data fields (1014, 1024, 1034, 1044) are transmitted using a variable bandwidth that is larger than the standard bandwidth, the first PPDU and the at least one additional PPDU (1020, 1030, 1040) are transmitted sequentially in a time domain, and the non-legacy header (1012, 1022, 1042) in each of the first PPDU and the at least one additional PPDU (1020, 1030, 1040) includes an additional PPDU field that indicates whether there is a subsequent PPDU. a transmission signal generator (700, 1512) which, in operation, generates a transmission signal having an aggregate physical layer protocol data unit (aggregate PPDU); and a transmitter which, in operation, transmits the generated transmission signal, characterized in that the aggregate PPDU includes a first PPDU and at least one additional PPDU (1020, 1030, 1040), the first PPDU comprising a legacy preamble (1001, 1003), a legacy header, a non-legacy header, a non-legacy preamble (1007, 1009), and a data field and each of the at least one additional PPDU (1020, 1030, 1040) comprising a non-legacy header (1022, 1042) and a data field (1024, 1034, 1044), the legacy preamble (1001, 1003), the legacy header and the non-legacy headers (1012, 1022, 1042) are transmitted using a standard bandwidth, the non-legacy preamble (1007, 1009) and the data fields (1014, 1024, 1034, 1044) are transmitted using a variable bandwidth that is larger than the standard bandwidth, the first PPDU and the at least one additional PPDU (1020, 1030, 1040) are transmitted sequentially in a time domain, and the non-legacy header (1012, 1022, 1042) in each of the first PPDU and the at least one additional PPDU (1020, 1030, 1040) includes an additional PPDU field that indicates whether there is a subsequent PPDU.
A system for targeting and damaging a growing plant or crop, the system comprising: a laser operable to generate a beam of energy sufficient to damage a plant when the plant is exposed to the beam and located at least 350 meters away; a controller operable to determine whether a target of the energy beam is a plant to be damaged, and in response to the determination: prevent the energy beam from reaching the target, if the target is not a plant to be damaged, and cause the energy beam to reach the target, if the target is a plant to be damaged; and an aircraft operable to position the laser and the controller airborne at least 350 meters away from the plant; wherein the controller includes: - a sensor operable to sense infrared radiation emitted by an animal, and generate data from the sensed radiation that represents a thermal image of the animal, and - circuity for comparing the generated data with data that represents a thermal image of a known animal. a laser operable to generate a beam of energy sufficient to damage a plant when the plant is exposed to the beam and located at least 350 meters away; a controller operable to determine whether a target of the energy beam is a plant to be damaged, and in response to the determination: prevent the energy beam from reaching the target, if the target is not a plant to be damaged, and cause the energy beam to reach the target, if the target is a plant to be damaged; and prevent the energy beam from reaching the target, if the target is not a plant to be damaged, and cause the energy beam to reach the target, if the target is a plant to be damaged; and an aircraft operable to position the laser and the controller airborne at least 350 meters away from the plant; wherein the controller includes: - a sensor operable to sense infrared radiation emitted by an animal, and generate data from the sensed radiation that represents a thermal image of the animal, and - circuity for comparing the generated data with data that represents a thermal image of a known animal. - a sensor operable to sense infrared radiation emitted by an animal, and generate data from the sensed radiation that represents a thermal image of the animal, and - circuity for comparing the generated data with data that represents a thermal image of a known animal.
A method for welding a first powder metallurgical part to a second powder metallurgical part, the method comprising: working a first face of the first PM part; working a first face of the second PM part; heat treating at least along the first faces of the first PM part and the second PM part; and friction welding the first face of the first part to the first face of the second part; wherein the first PM part and the second PM part are nickel-based superalloy; characterised in that: the working of the first faces of the first PM part and the second PM part is sufficient to achieve enough local compressive residual stress to introduce sufficient strain energy into the part faces prior to welding to refine grain; and in that the heat treating of the first faces of the first PM part and the second PM part after the working but before the friction welding reconstitutes the grains in the worked zone. working a first face of the first PM part; working a first face of the second PM part; heat treating at least along the first faces of the first PM part and the second PM part; and friction welding the first face of the first part to the first face of the second part; wherein the first PM part and the second PM part are nickel-based superalloy; the working of the first faces of the first PM part and the second PM part is sufficient to achieve enough local compressive residual stress to introduce sufficient strain energy into the part faces prior to welding to refine grain; and in that the heat treating of the first faces of the first PM part and the second PM part after the working but before the friction welding reconstitutes the grains in the worked zone.
A gas turbine engine having a combustor comprising: a liner having an inner surface; a plurality of tile assemblies secured to the inner surface of the liner, each tile assembly having a cold layer and a hot layer that are spaced apart from one another by an air gap, wherein the cold layer includes a plurality of ports for directing cooling air towards the hot layer, the ports are oriented in a direction normal to the hot layer, the hot layer includes a top surface, a bottom surface, and a plurality of cooling holes having an angle (φ) in the range of 30 degrees to 75 degrees relative to the top surface of the hot layer, the cooling holes have a leading edge and a trailing edge and an exit opening, the shape of the exit opening is circular, preferably fan shaped or oval shaped, in the top plan view, and cooling air is flowable from one port through the air gap 66 into multiple pathways (95, 97). a liner having an inner surface; a plurality of tile assemblies secured to the inner surface of the liner, each tile assembly having a cold layer and a hot layer that are spaced apart from one another by an air gap, wherein the cold layer includes a plurality of ports for directing cooling air towards the hot layer, the ports are oriented in a direction normal to the hot layer, the hot layer includes a top surface, a bottom surface, and a plurality of cooling holes having an angle (φ) in the range of 30 degrees to 75 degrees relative to the top surface of the hot layer, the cooling holes have a leading edge and a trailing edge and an exit opening, the shape of the exit opening is circular, preferably fan shaped or oval shaped, in the top plan view, and cooling air is flowable from one port through the air gap 66 into multiple pathways (95, 97).
A computer-implemented method, comprising: recognizing a first touch input at a first screen (104, 304) of a multi-screen system (102, 302, 2100), the first touch input including a first motion input to a first displayed object on the first screen (104, 304); recognizing a second touch input at a second screen (106, 306) of the multi-screen system (102, 302, 2100), the second touch input including a second motion input to a second displayed object on the second screen (106, 306); and determining (410, 412) one of: a pinch gesture or an expand gesture from the first and second motion inputs (316, 320) that are associated with the recognized first and second touch inputs (314, 318), wherein the pinch gesture is effective to condense the first displayed object for display on the first screen (104, 304) proximate a bezel of the multi-screen system (102, 302, 2100) that separates the first and second screens (104, 304, 106, 306), and effective to condense the second displayed object for display on the second screen (106, 306) proximate the bezel of the multi-screen system (102, 302, 2100), and wherein the expand gesture is effective to expand the first displayed object for display on the first screen (104, 304) proximate the bezel, and effective to expand the second displayed object for display on the second screen (106, 306) proximate the bezel of the multi-screen system (102, 302, 2100). recognizing a first touch input at a first screen (104, 304) of a multi-screen system (102, 302, 2100), the first touch input including a first motion input to a first displayed object on the first screen (104, 304); recognizing a second touch input at a second screen (106, 306) of the multi-screen system (102, 302, 2100), the second touch input including a second motion input to a second displayed object on the second screen (106, 306); and determining (410, 412) one of: a pinch gesture or an expand gesture from the first and second motion inputs (316, 320) that are associated with the recognized first and second touch inputs (314, 318), wherein the pinch gesture is effective to condense the first displayed object for display on the first screen (104, 304) proximate a bezel of the multi-screen system (102, 302, 2100) that separates the first and second screens (104, 304, 106, 306), and effective to condense the second displayed object for display on the second screen (106, 306) proximate the bezel of the multi-screen system (102, 302, 2100), and wherein the expand gesture is effective to expand the first displayed object for display on the first screen (104, 304) proximate the bezel, and effective to expand the second displayed object for display on the second screen (106, 306) proximate the bezel of the multi-screen system (102, 302, 2100).
A method comprising: receiving, by a destination virtual routing node of a network device having a plurality of packet processors and a switch fabric comprising a plurality of fabric links coupling respective pairs of the plurality of packet processors at respective fabric interfaces of the plurality of packet processors, one or more packets; determining, by the destination virtual routing node, whether the one or more packets are forwarded on a first path through the switch fabric or a second path through the switch fabric; obtaining, by the destination virtual routing node, a buffering time period computed from one or more timestamps included in a sampling packet, wherein the one or more timestamps are indicative of a time taken by the sampling packet to travel on the first path; in response to determining that the one or more packets are forwarded on the second path, buffering, by the destination virtual routing node, the one or more packets for the buffering time period; and in response to the buffering time period having elapsed, transmitting, by the destination virtual routing node, the buffered one or more packets on an egress interface of the destination virtual routing node. receiving, by a destination virtual routing node of a network device having a plurality of packet processors and a switch fabric comprising a plurality of fabric links coupling respective pairs of the plurality of packet processors at respective fabric interfaces of the plurality of packet processors, one or more packets; determining, by the destination virtual routing node, whether the one or more packets are forwarded on a first path through the switch fabric or a second path through the switch fabric; obtaining, by the destination virtual routing node, a buffering time period computed from one or more timestamps included in a sampling packet, wherein the one or more timestamps are indicative of a time taken by the sampling packet to travel on the first path; in response to determining that the one or more packets are forwarded on the second path, buffering, by the destination virtual routing node, the one or more packets for the buffering time period; and in response to the buffering time period having elapsed, transmitting, by the destination virtual routing node, the buffered one or more packets on an egress interface of the destination virtual routing node.
A control system for one or more battery cells (118, 150, 162), comprising: - a bi-stable relay (120, 144, 168) configured to electrically connect the one or more battery cells (118, 150, 162) to a bus (26, 152, 170) when a state of the bi-stable relay (120, 144, 168) is in a first state, electrically disconnect the one or more battery cells (118, 150, 162) from the bus (26, 152, 170) when the state of the bi-stable relay (120, 144, 168) is in a second state, and to remain in the first or second state until instructed to switch the state by a control signal; and - a controller (124, 140, 142, 166) coupled to the one or more battery cells (118, 150, 162), characterized in that the controller (124, 140, 142, 166) is configured to: - be operatively coupled to the bi-stable relay (120, 144, 168) and send the control signal; - receive power from a primary source; - control operation of the bi-stable relay (120, 144, 168) using power from the primary source; and - receive power from the one or more battery cells (118, 150, 162) to control operation of the bi-stable relay (120, 144, 168) using the power from the one or more battery cells (118, 150, 162) in an event where the primary source does not provide power, while the bi-stable relay (120, 144, 168) is in the second state, wherein the one or more battery cells (118, 150, 162) is disconnected from the bus (26, 152, 170). - a bi-stable relay (120, 144, 168) configured to electrically connect the one or more battery cells (118, 150, 162) to a bus (26, 152, 170) when a state of the bi-stable relay (120, 144, 168) is in a first state, electrically disconnect the one or more battery cells (118, 150, 162) from the bus (26, 152, 170) when the state of the bi-stable relay (120, 144, 168) is in a second state, and to remain in the first or second state until instructed to switch the state by a control signal; and - a controller (124, 140, 142, 166) coupled to the one or more battery cells (118, 150, 162), - be operatively coupled to the bi-stable relay (120, 144, 168) and send the control signal; - receive power from a primary source; - control operation of the bi-stable relay (120, 144, 168) using power from the primary source; and - receive power from the one or more battery cells (118, 150, 162) to control operation of the bi-stable relay (120, 144, 168) using the power from the one or more battery cells (118, 150, 162) in an event where the primary source does not provide power, while the bi-stable relay (120, 144, 168) is in the second state, wherein the one or more battery cells (118, 150, 162) is disconnected from the bus (26, 152, 170).