mhurhangee/ep-ind-claims huggingface dataset:
A rodent or rodent cell comprising in its genome a hexanucleotide repeat expansion sequence inserted at an endogenous C9orf72 locus, wherein the hexanucleotide repeat expansion sequence: (i) comprises at least one repeat of the hexanucleotide sequence set forth as SEQ ID NO:1, (ii) replaces a non-coding sequence spanning between exon 1a and/or exon 1b and the ATG start codon of the endogenous C9orf72 locus, (iii) is in operable linkage to an endogenous C9orf72 regulatory sequence, and (iv) is expressed from an endogenous C9orf72 promoter. (i) comprises at least one repeat of the hexanucleotide sequence set forth as SEQ ID NO:1, (ii) replaces a non-coding sequence spanning between exon 1a and/or exon 1b and the ATG start codon of the endogenous C9orf72 locus, (iii) is in operable linkage to an endogenous C9orf72 regulatory sequence, and (iv) is expressed from an endogenous C9orf72 promoter.
A method for changing an uplink and downlink subframe configuration for Time Division Duplex communication, the method comprising: determining, at a base station, the changed uplink and downlink subframe configuration for a pre-determined time period; generating configuration information for physical downlink control channel, PDCCH, information to be included in a first subframe of at least a radio frame, the PDCCH information representative of the determined changed uplink and downlink subframe configuration; and transmitting the first subframe that includes the PDCCH information. determining, at a base station, the changed uplink and downlink subframe configuration for a pre-determined time period; generating configuration information for physical downlink control channel, PDCCH, information to be included in a first subframe of at least a radio frame, the PDCCH information representative of the determined changed uplink and downlink subframe configuration; and transmitting the first subframe that includes the PDCCH information.
A heat exchanger plate for the use in a heat exchanger cassette, where the heat exchanger plate comprises a corrugated pattern having a plurality of ridges and valleys, and where the heat exchanger plate comprises a sealing gasket groove encircling a heat transfer surface that will be part of a contact-free fluid channel when two cassettes are positioned adjacent each other, characterized in that the sealing gasket groove comprises a base surface with a first, flat section and a second, bent section, where the bent section is angled with the angle α being in the interval of 1 to 20 degrees.
A medical apparatus, comprising: a medical instrument that is introduced into a body cavity; a fixing portion for fixing the medical instrument to a body wall inside the body cavity; a driven posture control portion connected to the medical instrument such that a posture of the medical instrument can be changed, and rotably connected to the fixing portion; a movable portion which is interposed between the medical instrument and the fixing portion and movably connects the medical instrument to the fixing portion; an extracorporeal device that is installed on a body surface outside the body and has a posture control portion that is rotatably provided and moves the driven posture control portion in a contactless manner from outside the body so that a posture position of the medical instrument can be changed relative to the fixing portion; and a posture position fixing member provided to the extracorporeal device, for fixing a rotation position of the posture control portion and fixing the posture position of the medical instrument relative to the fixing portion. a medical instrument that is introduced into a body cavity; a fixing portion for fixing the medical instrument to a body wall inside the body cavity; a driven posture control portion connected to the medical instrument such that a posture of the medical instrument can be changed, and rotably connected to the fixing portion; a movable portion which is interposed between the medical instrument and the fixing portion and movably connects the medical instrument to the fixing portion; an extracorporeal device that is installed on a body surface outside the body and has a posture control portion that is rotatably provided and moves the driven posture control portion in a contactless manner from outside the body so that a posture position of the medical instrument can be changed relative to the fixing portion; and a posture position fixing member provided to the extracorporeal device, for fixing a rotation position of the posture control portion and fixing the posture position of the medical instrument relative to the fixing portion.
Constructed wetland installation for treating wastewater and for producing energy, said installation comprising: - a primary sedimentation tank and at least one train of free surface constructed wetlands (FWSG) consisting of the following zones: - a first fully vegetated anaerobic zone with Eichhomia crassipes (zone 1), - a second open-water nitrification zone comprising the submerged macrophytes Myriophyllum spicatum which are capable of natural reaeration processes during daylight periods (zone 2), and a - a third vegetated denitrification and sedimentation zone with Eichhornia crassipes (zone 3) and - a seed retention system, - a harvesting system, - a digester, - a reformer, - a hydrogen storage system, - a boiler, - a greenhouse heating system and - a greenhouse whereby the hydrogen storage system is configured to supply hydrogen to the boiler, in order to heat the digester, and to the greenhouse heating system. - a primary sedimentation tank and at least one train of free surface constructed wetlands (FWSG) consisting of the following zones: - a first fully vegetated anaerobic zone with Eichhomia crassipes (zone 1), - a second open-water nitrification zone comprising the submerged macrophytes Myriophyllum spicatum which are capable of natural reaeration processes during daylight periods (zone 2), and a - a third vegetated denitrification and sedimentation zone with Eichhornia crassipes (zone 3) and - a seed retention system, - a harvesting system, - a digester, - a reformer, - a hydrogen storage system, - a boiler, - a greenhouse heating system and - a greenhouse
Telescopic seat post, in particular for fastening in a seat tube of a bicycle, with - a telescopic element designed tubular with a longitudinal axis and a cavity extending along the longitudinal axis, - a piston rod extending along the longitudinal axis in the cavity of the telescopic element, - a force accumulator connected to the piston rod for moving the piston rod in the direction of the longitudinal axis, wherein an intermediate element, displaceable along the piston rod and along the telescopic segment in the direction of the longitudinal axis, which is releasably fastenable to the piston rod in different positions along the longitudinal axis and is releasably fastenable in different positions along the longitudinal axis of the telescopic segment independently of the position on the piston rod, is provided. - a telescopic element designed tubular with a longitudinal axis and a cavity extending along the longitudinal axis, - a piston rod extending along the longitudinal axis in the cavity of the telescopic element, - a force accumulator connected to the piston rod for moving the piston rod in the direction of the longitudinal axis,
A cutting insert comprising: a main body portion comprising: an upper surface; a lower surface; a side surface connected to the upper surface and the lower surface; a cutting edge located at an intersection of the upper surface and the side surface; a first rake portion on the upper surface; and a flat surface located nearer to the inside of the main body portion than the first rake portion, wherein the cutting edge comprises: a major cutting edge that is arcuate and convex toward outside of the main body portion; and a minor cutting edge that is arcuate and convex toward outside of the main body portion and that has a curvature radius smaller than a curvature radius of the major cutting edge, wherein the first rake portion is inclined and approaches the lower surface as moving from the major cutting edge toward an inside of the main body portion and is located along the major cutting edge, wherein an inclination angle (α1, α2, α3) of the first rake portion becomes smaller as moving from a part continuous with one end of the major cutting edge toward a part continuous with another end of the major cutting edge, characterised in that, in plan view, the flat surface is farther from the major cutting edge in a center of the major cutting edge than in both ends of the major cutting edge. a main body portion comprising: an upper surface; a lower surface; a side surface connected to the upper surface and the lower surface; a cutting edge located at an intersection of the upper surface and the side surface; a first rake portion on the upper surface; and a flat surface located nearer to the inside of the main body portion than the first rake portion, an upper surface; a lower surface; a side surface connected to the upper surface and the lower surface; a cutting edge located at an intersection of the upper surface and the side surface; a first rake portion on the upper surface; and a flat surface located nearer to the inside of the main body portion than the first rake portion, wherein the cutting edge comprises: a major cutting edge that is arcuate and convex toward outside of the main body portion; and a minor cutting edge that is arcuate and convex toward outside of the main body portion and that has a curvature radius smaller than a curvature radius of the major cutting edge, a major cutting edge that is arcuate and convex toward outside of the main body portion; and a minor cutting edge that is arcuate and convex toward outside of the main body portion and that has a curvature radius smaller than a curvature radius of the major cutting edge, wherein the first rake portion is inclined and approaches the lower surface as moving from the major cutting edge toward an inside of the main body portion and is located along the major cutting edge, wherein an inclination angle (α1, α2, α3) of the first rake portion becomes smaller as moving from a part continuous with one end of the major cutting edge toward a part continuous with another end of the major cutting edge, characterised in that, in plan view, the flat surface is farther from the major cutting edge in a center of the major cutting edge than in both ends of the major cutting edge.
An abatement system for pollutants produced by an internal combustion engine having an intake pipe and an exhaust pipe, the system comprising - a device for the abatement of pollutants contained in the exhaust gases produced by the internal combustion engine, wherein said device comprises at least a first treatment portion (ATS1, ATS1') of exhaust gases comprising a NSC, - fuel metering means (J1, J1') adapted to introduce fuel into said first treatment portion, - a first cooler arranged on said exhaust pipe upstream of said first treatment portion, and comprising its own bypass means BP1, FP2) for adjusting a temperature of said first treatment portion; characterized by comprising - a second treatment portion arranged downstream of said first treatment portion and comprising an active SCR, and - a relating metering device for a urea-based additive arranged at the second treatment portion upstream of the active SCR, or between the first and the second treatment portion (ATS1, ATS2), or upstream of the first treatment portion. - a device for the abatement of pollutants contained in the exhaust gases produced by the internal combustion engine, wherein said device comprises at least a first treatment portion (ATS1, ATS1') of exhaust gases comprising a NSC, - fuel metering means (J1, J1') adapted to introduce fuel into said first treatment portion, - a first cooler arranged on said exhaust pipe upstream of said first treatment portion, and comprising its own bypass means BP1, FP2) for adjusting a temperature of said first treatment portion; - a second treatment portion arranged downstream of said first treatment portion and comprising an active SCR, and - a relating metering device for a urea-based additive arranged at the second treatment portion upstream of the active SCR, or between the first and the second treatment portion (ATS1, ATS2), or upstream of the first treatment portion.
Motor vehicle comprising an understructure provided with a rear floor, the vehicle also comprising a fuel tank situated at the front of the rear floor, a spare wheel being disposed above the rear floor at a height having a zone of overlap with the height of a rear zone of the tank, the vehicle comprising a protective barrier fastened to the structure of the understructure and to the rear floor and at least partially interposed between the spare wheel and the rear zone of the fuel tank, the spare wheel being disposed substantially horizontally above a functional member of the vehicle, in particular a service battery of the 12V or equivalent type, resting on an upper face of the rear floor, the rear floor being constituted of a shell made of plastic or composite material, in particular of SMC (Sheet Moulding Compound) type, supported laterally by two rear lateral side members (3, 4) of the understructure, which extend in the substantially longitudinal direction of the vehicle, the shell also being supported at the front by a central understructure crossmember, extending in the transverse direction of the vehicle, the shell comprising a central indentation having the overall shape of a bowl in which the battery is housed, characterized in that the protective barrier is made from mechanically welded metal tubes, and comprises a front bar and also a rear bar that each extend substantially in the transverse direction of the vehicle, the front bar bearing on the central understructure crossmember, while the rear bar at least partially enters the indentation and conforms to a front wall of the latter, the front bar and the rear bar being connected at their lateral ends by two lateral mounting plates (13, 14), and between these by a plurality of protective tubes that each extend in a substantially vertical plane.
A compound of the formula: or a pharmaceutically acceptable salt thereof, for use in a method for the treatment of Retinoblastoma-positive (Rb) cancer in a host, comprising administering an effective amount of the compound, wherein the Retinoblastoma-positive (Rb) cancer is selected from the group consisting of Rb-positive breast cancer, Rb-positive colon cancer, Rb-positive ovarian cancer, Rb-positive nonsmall cell lung cancer, Rb-positive prostate cancer, and Rb-positive glioblastoma. for use in a method for the treatment of Retinoblastoma-positive (Rb) cancer in a host, comprising administering an effective amount of the compound, wherein the Retinoblastoma-positive (Rb) cancer is selected from the group consisting of Rb-positive breast cancer, Rb-positive colon cancer, Rb-positive ovarian cancer, Rb-positive nonsmall cell lung cancer, Rb-positive prostate cancer, and Rb-positive glioblastoma.
A gas turbine engine comprising a duct casing and a linkage for actuating a seal in said gas turbine engine, said linkage comprising: a first bell crank assembly, a second bell crank assembly, a first connecting link connecting said first bell crank assembly to said second bell crank assembly such that motion of said first bell crank assembly effects motion of said second bell crank assembly, and a bridge arm attaching said first bell crank assembly to said second bell crank assembly; said first bell crank assembly having a crank having a first arm and a second arm; characterised in that the gas turbine engine comprises: a bracket of said first bell crank assembly which is mounted to said duct casing; and in that: said duct casing has a radially outwardly extending flange; said first arm is disposed radially outwardly of said second arm and is above said flange; and wherein motive force applied to said second arm rotates said first arm above said flange. a first bell crank assembly, a second bell crank assembly, a first connecting link connecting said first bell crank assembly to said second bell crank assembly such that motion of said first bell crank assembly effects motion of said second bell crank assembly, and a bridge arm attaching said first bell crank assembly to said second bell crank assembly; said first bell crank assembly having a crank having a first arm and a second arm; characterised in that the gas turbine engine comprises: a bracket of said first bell crank assembly which is mounted to said duct casing; and in that: said duct casing has a radially outwardly extending flange; said first arm is disposed radially outwardly of said second arm and is above said flange; and wherein motive force applied to said second arm rotates said first arm above said flange. said duct casing has a radially outwardly extending flange; said first arm is disposed radially outwardly of said second arm and is above said flange; and wherein motive force applied to said second arm rotates said first arm above said flange.
A transdermal absorption preparation comprising: a support; and an adhesive layer formed on at least one side of the support, wherein the adhesive layer contains 2.5% to 8% by mass phosphatidylcholine, 25.0% to 30.0%by mass of an adhesive component, 40.0% to 75.0%by mass of a lipophilic component and 8.5 to 12.0 parts by mass carnitine with respect to phosphatidylcholine mass taken as 100 parts, wherein the entire mass of the adhesive layer is 100% by mass, wherein the adhesive component is a styrene-based block copolymer selected from styrene-butadiene block copolymers and hydrogenated styrene-butadiene block copolymers having a weight average molecular weight of 10,000 to 5,500,000, styrene-isoprene block copolymers and hydrogenated styrene-isoprene block copolymers having a weight average molecular weight of 10,000 to 5,500,000 and styrene-isoprene-styrene block copolymers and hydrogenated styrene-isoprene-styrene block copolymers having a weight average molecular weight of 18,000 to 5,500,000, and wherein the weight average molecular weight is measured by gel filtration chromatography. wherein the adhesive layer contains 2.5% to 8% by mass phosphatidylcholine, 25.0% to 30.0%by mass of an adhesive component, 40.0% to 75.0%by mass of a lipophilic component and 8.5 to 12.0 parts by mass carnitine with respect to phosphatidylcholine mass taken as 100 parts, wherein the entire mass of the adhesive layer is 100% by mass, wherein the adhesive component is a styrene-based block copolymer selected from styrene-butadiene block copolymers and hydrogenated styrene-butadiene block copolymers having a weight average molecular weight of 10,000 to 5,500,000, styrene-isoprene block copolymers and hydrogenated styrene-isoprene block copolymers having a weight average molecular weight of 10,000 to 5,500,000 and styrene-isoprene-styrene block copolymers and hydrogenated styrene-isoprene-styrene block copolymers having a weight average molecular weight of 18,000 to 5,500,000, and wherein the weight average molecular weight is measured by gel filtration chromatography.
An illumination device comprising: - a strip configured as a U-profile in which at least one guide path is worked into both the legs (6, 7) which run parallel to one another - a large number of LEDs (light-emitting diodes) attached to the strip, by means of which the light waves are emitted in a lighting spread, and - at least one light wave divider configured as a thin-walled foil with bending flexibility that can be inserted into two guide paths running parallel to one another, - at least one optical structure provided on or in the foil arranged in the lighting spread of the LEDs, - in which the foil runs continuously along the entire length of the strip when installed. characterised in that, the foil consists of at least two layers (15, 16) which are connected to one another in the particular parting plane, that the optical structure is arranged in one of the layers (15, 16) of the foil or in the parting plane between two adjacent layers (15, 16) of the foil, and that the optical structure is configured as a Fresnel lens structure equipped with a linear or polygonal optical structure. - a strip configured as a U-profile in which at least one guide path is worked into both the legs (6, 7) which run parallel to one another - a large number of LEDs (light-emitting diodes) attached to the strip, by means of which the light waves are emitted in a lighting spread, and - at least one light wave divider configured as a thin-walled foil with bending flexibility that can be inserted into two guide paths running parallel to one another, - at least one optical structure provided on or in the foil arranged in the lighting spread of the LEDs, - in which the foil runs continuously along the entire length of the strip when installed.
A power semiconductor module arrangement comprising: a substrate comprising a dielectric insulation layer, and a first metallization layer attached to the dielectric insulation layer; at least one semiconductor body mounted on the first metallization layer; and a first layer comprising an encapsulant, the first layer being arranged on the substrate and covering the first metallization layer and the at least one semiconductor body, wherein the first layer is configured to release liquid or oil at temperatures exceeding a defined threshold temperature, characterized in that at least one of the following applies: the viscosity of the liquid or oil released from the encapsulant is lower than 1 mPas; and a surface tension of the liquid or oil released from the encapsulant at room temperature is less than 25 mNm -1. a substrate comprising a dielectric insulation layer, and a first metallization layer attached to the dielectric insulation layer; at least one semiconductor body mounted on the first metallization layer; and a first layer comprising an encapsulant, the first layer being arranged on the substrate and covering the first metallization layer and the at least one semiconductor body, wherein the first layer is configured to release liquid or oil at temperatures exceeding a defined threshold temperature, characterized in that at least one of the following applies: the viscosity of the liquid or oil released from the encapsulant is lower than 1 mPas; and a surface tension of the liquid or oil released from the encapsulant at room temperature is less than 25 mNm -1. the viscosity of the liquid or oil released from the encapsulant is lower than 1 mPas; and a surface tension of the liquid or oil released from the encapsulant at room temperature is less than 25 mNm -1.
Inductor for heating a geological formation, especially a reservoir, of a substance containing hydrocarbons, for example an oil sand, oil shale or heavy oil reservoir, by means of electromagnetic induction, especially for extracting the substance containing hydrocarbons from the reservoir, comprising at least one conductor, wherein the conductor has at least one interruption point, characterised in that a rounded conductive body is fitted to at least to one end area of the conductor at the interruption point.
Electrical energy storage device, comprising at least one electrical component being a capacitor and a busbar for electrical power distribution, wherein at least a first contact side or at least a second contact side of the electrical component is connected to the busbar for an electrical connection by a contact element, in particular a flat contact element, and wherein the contact element is formed at least partially as a mesh characterized in that the contact element is constructed such that the contact element surrounds the arrangement of capacitors and the busbar in the region of an edge of the busbar.