mhurhangee/ep-ind-claims huggingface dataset:
A compound according to the formula or a stereoisomer, tautomer, salt, or hydrate thereof: wherein: R 2 and R 3 are each independently hydrogen, C1-C6-alkyl, C1-C6-alkoxy, halogen, cyano, C1-C6-alkylamino or di-(C1-C6-alkyl)amino; W is O, S, or NR e, wherein R e is selected from hydrogen or C1-C6-alkyl; or W represents bonding of two hydrogen atoms to a carbon atom, forming an optionally substituted methylene group: wherein R f is selected from hydrogen or C1-C6-alkyl; R 4 is wherein R a is optionally substituted aryl or heteroaryl; R b is C1-C6-alkyl, trifluoromethyl, hydroxymethyl, methoxymethyl, aminomethyl, di-(C1-C6-alkyl)aminomethyl or heterocyclylaminomethyl; R c is selected from hydrogen, hydroxy, C1-C6-alkoxy, or C1-C6-alkyl; R d is selected from hydrogen, or C1-C6-alkyl; and R 1 is independently selected from optionally substituted heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, heterocyclyloxyalkyl, heteroalkyl, heterocyclylaminoalkyl, aminoalkyl, C1-C6-alkylaminoalkyl, di-(C1-C6-alkyl)-aminoalkyl, aminocycloalkyl, alkylaminocycloalkyl, di-(C1-C6-alkyl)-aminocycloalkyl, di-(C1-C6-alkyl)-aminocycloalkylalkyl, wherein the substituents are selected from hydrogen, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, amino, amidino, carboxamido, sulfonamido, hydroxy, cyano, primary, secondary or tertiary amino, halo, azido, C1-C6-alkoxyalkyl, cyanoalkyl, azidoalkyl, haloalkyl, hydroxyalkyl, methanesulfonylalkyl, primary, secondary or tertiary amino-alkyl, optionally substituted aryl, heteroaryl, heteroalkyl, heterocyclyl, cycloalkyl, alkenyl and alkynyl. R 2 and R 3 are each independently hydrogen, C1-C6-alkyl, C1-C6-alkoxy, halogen, cyano, C1-C6-alkylamino or di-(C1-C6-alkyl)amino; W is O, S, or NR e, wherein R e is selected from hydrogen or C1-C6-alkyl; or W represents bonding of two hydrogen atoms to a carbon atom, forming an optionally substituted methylene group:
Measuring device for determining the transition between a liquid and a solid phase of a medium comprising: a. a container comprising walls enclosing a space and the walls being impermeable to the medium; b. a first proximity sensor disposed within the container, wherein the container comprises a first end and an opposing second end, the measuring devices comprises the medium within the space and the medium is disposed at the second end, and the first proximity sensor is disposed at the first end and configured to determine the distance between the surface of the proximity sensor and the surface of the medium; and c. a processing module operatively coupled to the proximity sensor and configured to trigger measurements by the proximity sensor at at least two predetermined points in time t1 and t2, wherein the processing module is further configured to determine that the distance between the surface of the proximity sensor and the surface of the medium has changed beyond a threshold between the measurements at t1 and t2, and thus to determine that the transition between the liquid and the solid phase of the medium occurred. a. a container comprising walls enclosing a space and the walls being impermeable to the medium; b. a first proximity sensor disposed within the container, wherein the container comprises a first end and an opposing second end, the measuring devices comprises the medium within the space and the medium is disposed at the second end, and the first proximity sensor is disposed at the first end and configured to determine the distance between the surface of the proximity sensor and the surface of the medium; and the container comprises a first end and an opposing second end, the measuring devices comprises the medium within the space and the medium is disposed at the second end, and the first proximity sensor is disposed at the first end and configured to determine the distance between the surface of the proximity sensor and the surface of the medium; and c. a processing module operatively coupled to the proximity sensor and configured to trigger measurements by the proximity sensor at at least two predetermined points in time t1 and t2, wherein the processing module is further configured to determine that the distance between the surface of the proximity sensor and the surface of the medium has changed beyond a threshold between the measurements at t1 and t2, and thus to determine that the transition between the liquid and the solid phase of the medium occurred.
A base station of a first wireless communication system comprising the base station and one or more terminals, (5, 7) wherein a first terminal of the first wireless communication system has a function of performing data transmission within the data transmission period specified by the control signal of the base station, and wherein: the base station is capable of specifying a data transmission period of the one or more terminals using a control signal, the base station has a function of being capable of receiving a signal transmitted by a second terminal of a second wireless communication system and of knowing a transmission period of the second wireless communication system, in a case that the base station receives a transmission signal from the second terminal after the base station has transmitted a first control signal and designated a first data transmission period of the first terminal and/or before the base station transmits a second control signal and designates a second data transmission period of the first terminal, the base station is operable to confirm the transmission period of the second wireless communication system by the transmission signal from the second terminal before transmission of the second control signal which designates the second data transmission period of the first terminal, and in a case that the base station receives the transmission signal from the second terminal of the second wireless communication system before transmission of the second control signal, the base station is operable to readjust the data transmission period of the first terminal and/or the data transmission period of the second wireless communication system to not overlap with each other. the base station is capable of specifying a data transmission period of the one or more terminals using a control signal, the base station has a function of being capable of receiving a signal transmitted by a second terminal of a second wireless communication system and of knowing a transmission period of the second wireless communication system, in a case that the base station receives a transmission signal from the second terminal after the base station has transmitted a first control signal and designated a first data transmission period of the first terminal and/or before the base station transmits a second control signal and designates a second data transmission period of the first terminal, the base station is operable to confirm the transmission period of the second wireless communication system by the transmission signal from the second terminal before transmission of the second control signal which designates the second data transmission period of the first terminal, and in a case that the base station receives the transmission signal from the second terminal of the second wireless communication system before transmission of the second control signal, the base station is operable to readjust the data transmission period of the first terminal and/or the data transmission period of the second wireless communication system to not overlap with each other.
Method for supporting a lane-changing process for a vehicle with a speed control device, wherein the speed control device controls a speed of the vehicle to a target speed, comprising the following steps: receiving surroundings data of a surroundings of the vehicle by means of an input device, wherein the surroundings data comprise at least information about other vehicles in a target lane, determining a current traffic density and a current flow speed in the target lane on the basis of the surroundings data by means of an evaluation device, wherein the traffic density is defined as vehicles per portion of road, and wherein the flow speed is an average speed of the vehicles in the target lane, adapting the target speed on the basis of the determined current traffic density and the current flow speed by means of the evaluation device, transferring the adapted target speed to the speed control device. receiving surroundings data of a surroundings of the vehicle by means of an input device, wherein the surroundings data comprise at least information about other vehicles in a target lane, determining a current traffic density and a current flow speed in the target lane on the basis of the surroundings data by means of an evaluation device, wherein the traffic density is defined as vehicles per portion of road, and wherein the flow speed is an average speed of the vehicles in the target lane, adapting the target speed on the basis of the determined current traffic density and the current flow speed by means of the evaluation device, transferring the adapted target speed to the speed control device.
A panel assembly comprising: a panel; a beam attached to the panel; and a plurality of stiffeners attached to the panel, wherein each stiffener comprises a respective bridge which crosses over the beam at an intersection from a first side of the beam to a second side of the beam, each bridge has an outer surface facing away from the panel and an inner surface facing towards the panel, the inner surface of each bridge deviates away from the panel to form a recess at the intersection, and the outer surface of each bridge deviates away from the panel to form a protrusion at the intersection.
A rotary-vane vacuum pump with an outlet assembly, the rotary-vane vacuum pump comprising a rotor with at least one vane housed in a pump chamber, and the outlet assembly comprising: - at least a first outlet conduct comprising a first inner aperture adapted to extract a fluid from an internal cavity, and a first outer aperture adapted to expel the extracted fluid into an outside area of the vacuum pump; characterized in that the outlet assembly further comprises: - at least a second outlet conduct comprising a second inner aperture also adapted to extract the fluid from the internal cavity of the vacuum pump, and a second outer aperture also adapted to expel the extracted fluid into an outside area of the vacuum pump; being the second inner aperture disposed at a greater height than the first inner aperture, wherein the height of the first and second inner apertures (110,210) is defined: along an axis perpendicular to a wall of the internal cavity crossed by at least one of the at least a first outlet conduct and the at least a second outlet conduct, or along an axis perpendicular to at least one of the first outer aperture and the second outer aperture, or in a vertical direction on the wall of the vacuum pump where the first and second conducts (100,200) open to the outside area of the vacuum pump. - at least a first outlet conduct comprising a first inner aperture adapted to extract a fluid from an internal cavity, and a first outer aperture adapted to expel the extracted fluid into an outside area of the vacuum pump; - at least a second outlet conduct comprising a second inner aperture also adapted to extract the fluid from the internal cavity of the vacuum pump, and a second outer aperture also adapted to expel the extracted fluid into an outside area of the vacuum pump; being the second inner aperture disposed at a greater height than the first inner aperture, wherein the height of the first and second inner apertures (110,210) is defined: along an axis perpendicular to a wall of the internal cavity crossed by at least one of the at least a first outlet conduct and the at least a second outlet conduct, or along an axis perpendicular to at least one of the first outer aperture and the second outer aperture, or in a vertical direction on the wall of the vacuum pump where the first and second conducts (100,200) open to the outside area of the vacuum pump.
An in vitro method for predicting the likelihood of mucosal healing in a subject having or suspected of having an inflammatory bowel disease, the method comprising: (a) measuring the level of a first set of markers to form a first marker score, wherein the first set of markers comprises SAA and VCAM, and optionally further comprises one or more of TWEAK, CRP, ICAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBirl, Fla2, FlaX, OmpC, and an anti-drug antibody, wherein lower levels of SAA and VCAM relative to the level of the same marker in patients with IBD but no mucosal healing are predictive of mucosal healing; (b) measuring the level of a second set of markers to form a second marker score, wherein the second set of markers comprises TGFA, and optionally further comprises one or more of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, and an anti-TNFα antibody,wherein a lower level of TGFA relative to the level of the same marker in patients with IBD but no mucosal healing is predictive of mucosal healing; (c) comparing the first marker score to the second marker score; and (d) predicting the likelihood of mucosal healing based upon the comparison in step (c). (a) measuring the level of a first set of markers to form a first marker score, wherein the first set of markers comprises SAA and VCAM, and optionally further comprises one or more of TWEAK, CRP, ICAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBirl, Fla2, FlaX, OmpC, and an anti-drug antibody, wherein lower levels of SAA and VCAM relative to the level of the same marker in patients with IBD but no mucosal healing are predictive of mucosal healing; (b) measuring the level of a second set of markers to form a second marker score, wherein the second set of markers comprises TGFA, and optionally further comprises one or more of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, and an anti-TNFα antibody,wherein a lower level of TGFA relative to the level of the same marker in patients with IBD but no mucosal healing is predictive of mucosal healing; (c) comparing the first marker score to the second marker score; and (d) predicting the likelihood of mucosal healing based upon the comparison in step (c).
An apparatus for controlling rendering of audio signals, comprising: a spatial cue renderer for receiving spatial cue information generated from one or more input audio signals, which are down-mixed signals encoded by and provided from a Spatial Audio Coding encoder, and control information on rendering of the input audio signals, and transforming the spatial cue information based on the control information, in order for a SAC decoder to perform decoding the input audio signals by using an SAC decoding method, and perform rendering onto the input audio signals based on the spatial cue information transformed by the spatial cue renderer, wherein the spatial cue renderer extracts audio signal information from the spatial cue information, adjusts the extracted audio signal information based on the control information, and transforms the spatial cue information through the adjusted audio signal information, wherein the spatial cue renderer transforms the spatial cue information by applying a panning law including at least of a sine panning law, a tangent panning law, or a constant power panning law, and wherein the control information includes audio scene information including one or more of output positions and output levels of the input audio signals, and is input from outside other than the SAC encoder. a spatial cue renderer for receiving spatial cue information generated from one or more input audio signals, which are down-mixed signals encoded by and provided from a Spatial Audio Coding encoder, and control information on rendering of the input audio signals, and transforming the spatial cue information based on the control information, in order for a SAC decoder to perform decoding the input audio signals by using an SAC decoding method, and perform rendering onto the input audio signals based on the spatial cue information transformed by the spatial cue renderer, wherein the spatial cue renderer extracts audio signal information from the spatial cue information, adjusts the extracted audio signal information based on the control information, and transforms the spatial cue information through the adjusted audio signal information, wherein the spatial cue renderer transforms the spatial cue information by applying a panning law including at least of a sine panning law, a tangent panning law, or a constant power panning law, and wherein the control information includes audio scene information including one or more of output positions and output levels of the input audio signals, and is input from outside other than the SAC encoder.
A microbicidal delivery system including: a microbicidal composition including: a microbicidal compound selected from one or more of the compounds of formula I, II or III, or a pharmaceutically acceptable salt or solvate thereof, where R represents a group of the formula IV and a carrier, excipient or diluent therefor; and a prophylactic device which is a condom; the microbicidal composition being carried on a surface of the prophylactic device or impregnated into the prophylactic device or covalently bound to the surface of the prophylactic device and being compatible therewith. a microbicidal composition including: a microbicidal compound selected from one or more of the compounds of formula I, II or III, or a pharmaceutically acceptable salt or solvate thereof, where R represents a group of the formula IV and a carrier, excipient or diluent therefor; and a microbicidal compound selected from one or more of the compounds of formula I, II or III, or a pharmaceutically acceptable salt or solvate thereof, where R represents a group of the formula IV and a carrier, excipient or diluent therefor; and a prophylactic device which is a condom;
A compound of formula I, or a pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer or isotope compound thereof, wherein, the carbon atom labelled by * is an asymmetric center; R1 and R2 are independently H, D, substituted or unsubstituted (C 1 -C 6)alkyl, substituted or unsubstituted (C 3 -C 6)cycloalkyl, R 6 -S 2 - or R 6 -C -; or, R 1 and R 2 and the nitrogen atom to which they are attached together form a 5-7 membered heterocycle containing N; R 6 is substituted or unsubstituted (C 3 -C 6)cycloalkyl; or (C 1 -C 6)alkyl, which is optionally substituted with one or more groups selected from D, halogen, hydroxyl, amino, (C 1 -C 6)alkyl amino, (C 1 -C 6)alkoxy and benzyloxy; X 1, X 2, X 3, X 4, X 5 and X 6 are independently CH, CD, CR 7 or N; R 7 is halogen or cyano; R 3 and R 4 are independently H, substituted or unsubstituted (C 1 -C 6)alkyl, substituted or unsubstituted (C 3 -C 6)cycloalkyl, or, substituted or unsubstituted (C 1 -C 6)alkyl-(C 3 -C 6)cycloalkyl; or, R 3 and R 4 and the oxygen atom to which they are attached together form a 5-7 membered heterocycle containing O; R 5 is substituted or unsubstituted (C 1 -C 6)alkyl; R 10, R 11 and R 12 are independently H or D; the substituent in substituted (C 1 -C 6)alkyl, substituted (C 3 -C 6)cycloalkyl, or, substituted (C 1 -C 6)alkyl-(C 3 -C 6)cycloalkyl is one or more selected from the group consisting of: D, halogen, hydroxyl, amino, (C 1 -C 6)alkyl amino, (C 1 -C 6)alkoxy and benzyloxy; when there are a plurality of substituents, the substituents are the same or different; provided that: one of X 1, X 2, X 3, X 4, X 5 and X 6 is N. wherein, the carbon atom labelled by * is an asymmetric center; R1 and R2 are independently H, D, substituted or unsubstituted (C 1 -C 6)alkyl, substituted or unsubstituted (C 3 -C 6)cycloalkyl, R 6 -S 2 - or R 6 -C -; or, R 1 and R 2 and the nitrogen atom to which they are attached together form a 5-7 membered heterocycle containing N; R 6 is substituted or unsubstituted (C 3 -C 6)cycloalkyl; or (C 1 -C 6)alkyl, which is optionally substituted with one or more groups selected from D, halogen, hydroxyl, amino, (C 1 -C 6)alkyl amino, (C 1 -C 6)alkoxy and benzyloxy; X 1, X 2, X 3, X 4, X 5 and X 6 are independently CH, CD, CR 7 or N; R 7 is halogen or cyano; R 3 and R 4 are independently H, substituted or unsubstituted (C 1 -C 6)alkyl, substituted or unsubstituted (C 3 -C 6)cycloalkyl, or, substituted or unsubstituted (C 1 -C 6)alkyl-(C 3 -C 6)cycloalkyl; or, R 3 and R 4 and the oxygen atom to which they are attached together form a 5-7 membered heterocycle containing O; R 5 is substituted or unsubstituted (C 1 -C 6)alkyl; R 10, R 11 and R 12 are independently H or D; the substituent in substituted (C 1 -C 6)alkyl, substituted (C 3 -C 6)cycloalkyl, or, substituted (C 1 -C 6)alkyl-(C 3 -C 6)cycloalkyl is one or more selected from the group consisting of: D, halogen, hydroxyl, amino, (C 1 -C 6)alkyl amino, (C 1 -C 6)alkoxy and benzyloxy; when there are a plurality of substituents, the substituents are the same or different; provided that: one of X 1, X 2, X 3, X 4, X 5 and X 6 is N.
A motor vehicle key, in particular for a motor vehicle radio key, having a key shank and a mounting element, wherein the key shank is arranged inside the mounting element, and a deformation element is arranged between the mounting element and the key shank, which deformation element is designed to be subsequently deformable, wherein the mounting element has at least one mounting recess (12, 13), and the key shank has at least one key shank recess (14, 15, 16, 17), wherein after the deformation of the deformation element, the deformed deformation element is arranged at least partially inside the mounting recess (12, 13), and at least partially inside the key shank recess (14, 15, 16, 17), and connects the key shank and the mounting element in a force fit and/or a form fit, characterised in that, the deformation element is formed from plastic.