A compound sea cucumber preparation product, mainly comprising 99 ∼ 70 wt% nanometer sea cucumber extract and 1 ∼ 30 wt% panax pseudo-ginseng saponins extract; wherein the product is a gray or light brown or brown powder, the content of sea cucumber polysaccharide is 2.5 ∼ 8.0wt %, and the content of panax pseudo-ginseng saponins is 0.3 ∼ 21.0wt%; wherein said nanometer sea cucumber extract is extracted according to steps as follows: Raw material processing: put the cut and leaned fresh sea cucumber or soaked sea cucumber into an airtight container; Heat and gelatination: at 70 ∼ 130°C, gelatinate for 1 min ∼ 20 hours; Freeze-dry: freeze-dry the gelatinated sea cucumber till the water content is less than 10wt%; Coarse crush: crush the freeze-dried sea cucumber for 1 ∼ 20min to obtain sea cucumber powder with fineness of 10 ∼ 300 mesh; Ultra-micro crush: ultra-micro crush the coarse crushed sea cucumber powder with an airflow crusher, to obtain the ultra-micro sea cucumber powder with fineness of 100 ∼ 3000 mesh; Nanometer crush: nanometer crush, by means of a high energy ball grinding mill, the ultra-micro sea cucumber powder obtained by the airflow crusher, the crushing time being 4 ∼ 20 hours, to obtain a fineness of up to 10 ∼ 1000nm; Enzymolysis and separation: dissolve the nanometer sea cucumber powder with water at the mass ratio of 1: 3 ∼ 10, add proteinase at the ratio of nanometer sea cucumber powder: proteinase equal to 1g: 0.1 ∼ 1010 mg and enzymolysis at corresponding pH value for 1 ∼ 5 hours at 40 ∼ 70°C, then apply heat to inactivate the proteinase, centrifuge at 0 ∼ 10°C, take the supernatant and carry out drying to obtain nanometer sea cucumber extract; Mix the nanometer sea cucumber extract with the panax pseudo-ginseng saponins extract at the ratio of nanometer sea cucumber extract: panax pseudo-ginseng saponins extract equal to 99 ∼ 70wt%: 1 ∼ 30wt%. Raw material processing: put the cut and leaned fresh sea cucumber or soaked sea cucumber into an airtight container; Heat and gelatination: at 70 ∼ 130°C, gelatinate for 1 min ∼ 20 hours; Freeze-dry: freeze-dry the gelatinated sea cucumber till the water content is less than 10wt%; Coarse crush: crush the freeze-dried sea cucumber for 1 ∼ 20min to obtain sea cucumber powder with fineness of 10 ∼ 300 mesh; Ultra-micro crush: ultra-micro crush the coarse crushed sea cucumber powder with an airflow crusher, to obtain the ultra-micro sea cucumber powder with fineness of 100 ∼ 3000 mesh; Nanometer crush: nanometer crush, by means of a high energy ball grinding mill, the ultra-micro sea cucumber powder obtained by the airflow crusher, the crushing time being 4 ∼ 20 hours, to obtain a fineness of up to 10 ∼ 1000nm; Enzymolysis and separation: dissolve the nanometer sea cucumber powder with water at the mass ratio of 1: 3 ∼ 10, add proteinase at the ratio of nanometer sea cucumber powder: proteinase equal to 1g: 0.1 ∼ 1010 mg and enzymolysis at corresponding pH value for 1 ∼ 5 hours at 40 ∼ 70°C, then apply heat to inactivate the proteinase, centrifuge at 0 ∼ 10°C, take the supernatant and carry out drying to obtain nanometer sea cucumber extract; Mix the nanometer sea cucumber extract with the panax pseudo-ginseng saponins extract at the ratio of nanometer sea cucumber extract: panax pseudo-ginseng saponins extract equal to 99 ∼ 70wt%: 1 ∼ 30wt%.