A system comprising: a catheter, a coolant source coupled to the catheter, and an energy source coupled to the catheter; wherein the catheter comprises: an elongated body (2000, 2500, 3000) through which a coolant from the coolant source is configured to flow, wherein the elongated body (2000, 2500, 3000) includes an inflow lumen (2011, 2511, 3011) and an outflow lumen (2021, 2511, 3021) configured to circulate the coolant; and an expandable balloon (2002, 2502, 3002) having a collapsed state and an expanded state, wherein the expandable balloon in the expanded state is dimensioned to contact an airway wall of a bronchial tree and the inflow lumen (2011, 2511, 3011) and the outflow lumen (2021, 2511, 3021) are positioned to circulate the coolant within the expandable balloon (2002, 2502, 3002), characterized in that the catheter further comprises an electrode (2004, 2504, 3004) coupled to and energized by the energy source, wherein the electrode (2004, 2504, 3004) is coupled to the expandable balloon (2002, 2502, 3002) such that the electrode is moved towards the airway wall as the expandable balloon moves from the collapsed state to the expanded state, the system is configured such that the energized electrode (2004, 2504, 3004) is configured to output a sufficient amount of energy to ablate a portion of a nerve trunk extending along the bronchial tree to attenuate nervous system signals transmitted to a portion of the bronchial tree while the expandable balloon is in the expanded state, and the expandable balloon is configured to absorb thermal energy from the airway wall to limit or prevent damage to superficial tissue of the airway wall, and the system is further configured such that the coolant can circulate proximate the electrode so as to cool an electrode-tissue interface of the airway wall to limit or prevent damage to tissue between the electrode and the nerve tissue. a catheter, a coolant source coupled to the catheter, and an energy source coupled to the catheter; wherein the catheter comprises: an elongated body (2000, 2500, 3000) through which a coolant from the coolant source is configured to flow, wherein the elongated body (2000, 2500, 3000) includes an inflow lumen (2011, 2511, 3011) and an outflow lumen (2021, 2511, 3021) configured to circulate the coolant; and an expandable balloon (2002, 2502, 3002) having a collapsed state and an expanded state, wherein the expandable balloon in the expanded state is dimensioned to contact an airway wall of a bronchial tree and the inflow lumen (2011, 2511, 3011) and the outflow lumen (2021, 2511, 3021) are positioned to circulate the coolant within the expandable balloon (2002, 2502, 3002), an elongated body (2000, 2500, 3000) through which a coolant from the coolant source is configured to flow, wherein the elongated body (2000, 2500, 3000) includes an inflow lumen (2011, 2511, 3011) and an outflow lumen (2021, 2511, 3021) configured to circulate the coolant; and an expandable balloon (2002, 2502, 3002) having a collapsed state and an expanded state, wherein the expandable balloon in the expanded state is dimensioned to contact an airway wall of a bronchial tree and the inflow lumen (2011, 2511, 3011) and the outflow lumen (2021, 2511, 3021) are positioned to circulate the coolant within the expandable balloon (2002, 2502, 3002), characterized in that the catheter further comprises an electrode (2004, 2504, 3004) coupled to and energized by the energy source, wherein the electrode (2004, 2504, 3004) is coupled to the expandable balloon (2002, 2502, 3002) such that the electrode is moved towards the airway wall as the expandable balloon moves from the collapsed state to the expanded state, the system is configured such that the energized electrode (2004, 2504, 3004) is configured to output a sufficient amount of energy to ablate a portion of a nerve trunk extending along the bronchial tree to attenuate nervous system signals transmitted to a portion of the bronchial tree while the expandable balloon is in the expanded state, and the expandable balloon is configured to absorb thermal energy from the airway wall to limit or prevent damage to superficial tissue of the airway wall, and the system is further configured such that the coolant can circulate proximate the electrode so as to cool an electrode-tissue interface of the airway wall to limit or prevent damage to tissue between the electrode and the nerve tissue.