A monoclonal antibody which specifically binds to human transmembrane 4 L six family member 5 (TM4SF5) protein, wherein the monoclonal antibody comprises a heavy chain variable region and a light chain variable region selected from the group consisting of: (a) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 4; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 6; a light chain CDR2 represented by SEQ ID NO: 7; and a light chain CDR3 represented by SEQ ID NO: 8; (b) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 12; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 16; (c) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 20; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 22; (d) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 26; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 28; and (e) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 32; a heavy chain CDR2 represented by SEQ ID NO: 33; and a heavy chain CDR3 represented by SEQ ID NO: 34; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 36; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 37. (a) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 4; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 6; a light chain CDR2 represented by SEQ ID NO: 7; and a light chain CDR3 represented by SEQ ID NO: 8; (b) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 12; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 16; (c) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 20; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 22; (d) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 26; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 14; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 28; and (e) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 32; a heavy chain CDR2 represented by SEQ ID NO: 33; and a heavy chain CDR3 represented by SEQ ID NO: 34; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 36; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 37.