Device for extracting physiological information from remotely detected electromagnetic radiation emitted or reflected by a subject, comprising: - an interface for receiving a data stream derivable from electromagnetic radiation emitted or reflected by a subject, the data stream comprising a sequence (76, 152) of signal samples (78a, 78b, 78c) including physiological information and indicative of disturbing motion, the signal samples (78a, 78b, 78c) representing at least one region of interest exhibiting an at least partially periodic indicative pattern attributable to at least one physiological parameter, and a non-indicative motion region; and - a processing unit configured for processing the sequence (76, 152) of signal samples (78a, 78b, 78c), comprising: - a stabilizing means configured for deriving a sequence (106, 158) of derivative motion compensated samples (108a, 108b, 108c) at least partially compensated for undesired overall motion, wherein the stabilizing means is configured for deriving the sequence (106, 158) of motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the signal samples (78a, 78b, 78c), and wherein the at least one region of interest is excluded from overall motion detection measures; - a motion compensation assessment means configured for detecting an evaluation parameter representative of motion compensation accuracy, wherein the motion compensation assessment means is configured for detecting a similarity between motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the motion compensated samples (108a, 108b, 108c); and - an extractor means configured for selectively deriving at least one characteristic signal (128, 172, 176) at least partially indicative of the at least partially periodic indicative pattern from the sequence (106, 158) of motion compensated samples (108a, 108b, 108c), wherein deriving the characteristic signal (128, 172, 176) is performed depending on the detected evaluation parameter. - an interface for receiving a data stream derivable from electromagnetic radiation emitted or reflected by a subject, the data stream comprising a sequence (76, 152) of signal samples (78a, 78b, 78c) including physiological information and indicative of disturbing motion, the signal samples (78a, 78b, 78c) representing at least one region of interest exhibiting an at least partially periodic indicative pattern attributable to at least one physiological parameter, and a non-indicative motion region; and - a processing unit configured for processing the sequence (76, 152) of signal samples (78a, 78b, 78c), comprising: - a stabilizing means configured for deriving a sequence (106, 158) of derivative motion compensated samples (108a, 108b, 108c) at least partially compensated for undesired overall motion, wherein the stabilizing means is configured for deriving the sequence (106, 158) of motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the signal samples (78a, 78b, 78c), and wherein the at least one region of interest is excluded from overall motion detection measures; - a motion compensation assessment means configured for detecting an evaluation parameter representative of motion compensation accuracy, wherein the motion compensation assessment means is configured for detecting a similarity between motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the motion compensated samples (108a, 108b, 108c); and - an extractor means configured for selectively deriving at least one characteristic signal (128, 172, 176) at least partially indicative of the at least partially periodic indicative pattern from the sequence (106, 158) of motion compensated samples (108a, 108b, 108c), wherein deriving the characteristic signal (128, 172, 176) is performed depending on the detected evaluation parameter. - a stabilizing means configured for deriving a sequence (106, 158) of derivative motion compensated samples (108a, 108b, 108c) at least partially compensated for undesired overall motion, wherein the stabilizing means is configured for deriving the sequence (106, 158) of motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the signal samples (78a, 78b, 78c), and wherein the at least one region of interest is excluded from overall motion detection measures; - a motion compensation assessment means configured for detecting an evaluation parameter representative of motion compensation accuracy, wherein the motion compensation assessment means is configured for detecting a similarity between motion compensated samples (108a, 108b, 108c) under consideration of at least one portion of the non-indicative motion region in the motion compensated samples (108a, 108b, 108c); and - an extractor means configured for selectively deriving at least one characteristic signal (128, 172, 176) at least partially indicative of the at least partially periodic indicative pattern from the sequence (106, 158) of motion compensated samples (108a, 108b, 108c), wherein deriving the characteristic signal (128, 172, 176) is performed depending on the detected evaluation parameter.