Nucleosides of the general Formula I where R 1 = Halogen, R 2 is selected from the group consisting of H, Halogen, OR 8, CN, N 3, NR 6 R 7 and prodrug residues bonded via an oxygen atom, wherein the prodrug residue is selected from the group consisting of where R 10 and R 11 mutually independently represent linear or branched C 1 -C 8 alkyl, aryl, which can also have heteroatoms, R 12 = linear or branched C 1 -C 8 alkyl, aralkyls, aryl, which can also have heteroatoms, R 13 = linear or branched C 1 -C 8 alkyl, where R 10 and R 11 mutually independently represent linear or branched C 1 -C 8 alkyl, aryl, which can also have heteroatoms, R 12 = linear or branched C 1 -C 8 alkyl, aralkyls, aryl, which can also have heteroatoms, R 13 = linear or branched C 1 -C 8 alkyl, R 14 = O-C 1 -C 8 alkyl, NH-C 1 -C 8 alkyl, N-(C 1 -C 8 alkyl) 2, where R 15 = linear or branched C 1 -C 8 alkyl, where R 15 = linear or branched C 1 -C 8 alkyl, R 16 = linear or branched C 1 -C 8 alkyl, O aryl where R 17 = linear or branched C 1 -C 8 alkyl, halogen, where R 18 = linear or branched C 1 -C 8 alkyl, aryl or heteroaryl, R 19 = alkyl-CO-, aryl-CO-, amino acid or peptide, where R 20 = linear or branched C 1 -C 8 alkyl, R 3 = H, linear or branched C 1 -C 8 alkyl, linear or branched C 1 -C 8 alkylene, R 4 = H, halogen, OR 8, N 3, NR 6 R 7, or R 4 together with R 1 represent a second bond between the C atoms neighbouring R 1 and R 4, R 5 = H, C 1 -C 8 alkyl or aryl and R 6, R 7, and R 8 mutually independently represent H, linear or branched C 1 -C 8 alkyl or acetyl, wherein compounds with the following residues are excluded: R 1 = F, R 2 = OH, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = O acetyl, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = triphosphate, R 3 = R 4 = R 5 = H, R 1 = Cl, R 2 = OH, R 3 = R 4 = R 5 = H. R 1 = Halogen, R 2 is selected from the group consisting of H, Halogen, OR 8, CN, N 3, NR 6 R 7 and prodrug residues bonded via an oxygen atom, wherein the prodrug residue is selected from the group consisting of where R 10 and R 11 mutually independently represent linear or branched C 1 -C 8 alkyl, aryl, which can also have heteroatoms, R 12 = linear or branched C 1 -C 8 alkyl, aralkyls, aryl, which can also have heteroatoms, R 13 = linear or branched C 1 -C 8 alkyl, where R 10 and R 11 mutually independently represent linear or branched C 1 -C 8 alkyl, aryl, which can also have heteroatoms, R 12 = linear or branched C 1 -C 8 alkyl, aralkyls, aryl, which can also have heteroatoms, R 13 = linear or branched C 1 -C 8 alkyl, R 14 = O-C 1 -C 8 alkyl, NH-C 1 -C 8 alkyl, N-(C 1 -C 8 alkyl) 2, where R 15 = linear or branched C 1 -C 8 alkyl, where R 15 = linear or branched C 1 -C 8 alkyl, R 16 = linear or branched C 1 -C 8 alkyl, O aryl where R 17 = linear or branched C 1 -C 8 alkyl, halogen, where R 18 = linear or branched C 1 -C 8 alkyl, aryl or heteroaryl, R 19 = alkyl-CO-, aryl-CO-, amino acid or peptide, where R 20 = linear or branched C 1 -C 8 alkyl, R 3 = H, linear or branched C 1 -C 8 alkyl, linear or branched C 1 -C 8 alkylene, R 4 = H, halogen, OR 8, N 3, NR 6 R 7, or R 4 together with R 1 represent a second bond between the C atoms neighbouring R 1 and R 4, R 5 = H, C 1 -C 8 alkyl or aryl and R 6, R 7, and R 8 mutually independently represent H, linear or branched C 1 -C 8 alkyl or acetyl, wherein compounds with the following residues are excluded: R 1 = F, R 2 = OH, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = O acetyl, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = triphosphate, R 3 = R 4 = R 5 = H, R 1 = Cl, R 2 = OH, R 3 = R 4 = R 5 = H. R 1 = F, R 2 = OH, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = O acetyl, R 3 = R 4 = R 5 = H, R 1 = F, R 2 = triphosphate, R 3 = R 4 = R 5 = H, R 1 = Cl, R 2 = OH, R 3 = R 4 = R 5 = H.