A method of coating a substrate, comprising: a) providing a substrate; b) applying two or more coatings to the substrate via flexography; wherein more than one coating station is used for applying the coatings; wherein the same or a different coating may be applied at each station; and wherein at least one coating is a water-based coating comprising: i) one or more polymer binders, in an amount of 25 wt% to 99 wt%, on a solids weight basis; and ii) one or more particles, in an amount of 0.1 wt% to 50 wt%, on a solids weight basis; wherein at least one polymer binder has a glass transition temperature (Tg) of less than 10°C; wherein at least one polymer binder has a heat seal onset temperature of less than 200°C, wherein the heat seal onset temperature is measured as defined in the description; wherein at least one particle has an average particle size of 4 μm to 100 μm; and wherein the water-based coatings have a dry coat weight of 2 g/m 2 to 40 g/m 2, wherein the at least one particle is selected from talc, calcium carbonate, high density polyethylene (HDPE) and N,N'-ethylene-bis-stearamide and wherein the average particle size is D 50 measured by laser diffraction method ISO 13320-1. a) providing a substrate; b) applying two or more coatings to the substrate via flexography; wherein more than one coating station is used for applying the coatings; wherein the same or a different coating may be applied at each station; and wherein at least one coating is a water-based coating comprising: i) one or more polymer binders, in an amount of 25 wt% to 99 wt%, on a solids weight basis; and ii) one or more particles, in an amount of 0.1 wt% to 50 wt%, on a solids weight basis; wherein at least one polymer binder has a glass transition temperature (Tg) of less than 10°C; wherein at least one polymer binder has a heat seal onset temperature of less than 200°C, wherein the heat seal onset temperature is measured as defined in the description; wherein at least one particle has an average particle size of 4 μm to 100 μm; and wherein the water-based coatings have a dry coat weight of 2 g/m 2 to 40 g/m 2, wherein the at least one particle is selected from talc, calcium carbonate, high density polyethylene (HDPE) and N,N'-ethylene-bis-stearamide and wherein the average particle size is D 50 measured by laser diffraction method ISO 13320-1. i) one or more polymer binders, in an amount of 25 wt% to 99 wt%, on a solids weight basis; and ii) one or more particles, in an amount of 0.1 wt% to 50 wt%, on a solids weight basis; wherein at least one polymer binder has a glass transition temperature (Tg) of less than 10°C; wherein at least one polymer binder has a heat seal onset temperature of less than 200°C, wherein the heat seal onset temperature is measured as defined in the description; wherein at least one particle has an average particle size of 4 μm to 100 μm; and wherein the water-based coatings have a dry coat weight of 2 g/m 2 to 40 g/m 2, wherein the at least one particle is selected from talc, calcium carbonate, high density polyethylene (HDPE) and N,N'-ethylene-bis-stearamide and wherein the average particle size is D 50 measured by laser diffraction method ISO 13320-1.