A compound having the Formula or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein, X is N or CR 4a; each R 1 is independently H or C 1-8 alkyl, R 2 is H or CH 3; each R 3 is independently H or C 1-8 alkyl; or two R 3 groups are joined together to form a 5 or 6-membered ring which is unsubstituted or substituted with from 1 to 4 R a; each R 4a, R 4b, R 4c and R 4d is independently selected from the group consisting of H, halogen, CN, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 hydroxyalkyl, C 1-8 haloalkyl, C 1-8 haloalkoxy, -X 1 -Y, -X 1 -SO 2 R 5a and -X 1 -NR 5b R 5c; each R 5a, R 5b and R 5c is independently selected from the group consisting of H, C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 alkylC -, C 3-7 cycloalkyl, 3- to 7-membered heterocycloalkyl, aryl, heteroaryl and an amino acid, or R 5b and R 5c are joined together to form a 4- to 6-membered ring; and wherein each of the 4- to 6-membered ring, C 3-7 cycloalkyl or 3- to 7-membered heterocycloalkyl, aryl and heteroaryl, are unsubstituted or substituted with from 1 to 4 R b; each X 1 is a bond, -O-, C 1-6 alkylene or -O-C 1-6 alkylene, wherein the alkylene portions are unsubstituted or substituted with 1 to 4 R c and 0 or 1 oxo; each R a, R b and R c is independently halogen, CN, OH, NH 2, CO 2 H, C 1-4 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl and phenyl, or two R c are combined to form a C 3-6 cycloalkyl which is unsubstituted or substituted with 1 to 3 R d; each Y is independently phenyl, a 5- or 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or C 3-6 cycloalkyl, each of which is unsubstituted or substituted with from 1 to 3 R d; and each R d is independently halogen, C 1-4 alkyl, amino, aminoC 1-4 alkyl, C 1-4 haloalkyl, OH, and C 1-4 hydroxyalkyl. or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein, X is N or CR 4a; each R 1 is independently H or C 1-8 alkyl, R 2 is H or CH 3; each R 3 is independently H or C 1-8 alkyl; or two R 3 groups are joined together to form a 5 or 6-membered ring which is unsubstituted or substituted with from 1 to 4 R a; each R 4a, R 4b, R 4c and R 4d is independently selected from the group consisting of H, halogen, CN, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 hydroxyalkyl, C 1-8 haloalkyl, C 1-8 haloalkoxy, -X 1 -Y, -X 1 -SO 2 R 5a and -X 1 -NR 5b R 5c; each R 5a, R 5b and R 5c is independently selected from the group consisting of H, C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 alkylC -, C 3-7 cycloalkyl, 3- to 7-membered heterocycloalkyl, aryl, heteroaryl and an amino acid, or R 5b and R 5c are joined together to form a 4- to 6-membered ring; and wherein each of the 4- to 6-membered ring, C 3-7 cycloalkyl or 3- to 7-membered heterocycloalkyl, aryl and heteroaryl, are unsubstituted or substituted with from 1 to 4 R b; each X 1 is a bond, -O-, C 1-6 alkylene or -O-C 1-6 alkylene, wherein the alkylene portions are unsubstituted or substituted with 1 to 4 R c and 0 or 1 oxo; each R a, R b and R c is independently halogen, CN, OH, NH 2, CO 2 H, C 1-4 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl and phenyl, or two R c are combined to form a C 3-6 cycloalkyl which is unsubstituted or substituted with 1 to 3 R d; each Y is independently phenyl, a 5- or 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or C 3-6 cycloalkyl, each of which is unsubstituted or substituted with from 1 to 3 R d; and each R d is independently halogen, C 1-4 alkyl, amino, aminoC 1-4 alkyl, C 1-4 haloalkyl, OH, and C 1-4 hydroxyalkyl.