A compound having Formula or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein L is -CH 2 O- or -OCH 2 -; U is CR u or N; V is -CH 2 -, -CH 2 CH 2 - or a single bond; each R 1a, R 1b, R 1c, R 1d and R 1e is independently H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; R u is H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; each R 2a, R 2b and R 2c is independently H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; R 3a is F, Cl, Br, I, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkoxy, C 1 -C 6 haloalkoxy or hydroxy-substituted C 1 -C 6 alkyl; R 3b is H, D, F, Cl, Br, I, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy or hydroxy-substituted C 1 -C 6 alkyl; and each R 4 and R 5 is independently H, D, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl, wherein each of the C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl and 5-10 membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from D, F, Cl, Br, I, -OH, -NH 2, -NO 2, -CN, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 3 -C 8 cycloalkyl or C 6 -C 10 aryl. L is -CH 2 O- or -OCH 2 -; U is CR u or N; V is -CH 2 -, -CH 2 CH 2 - or a single bond; each R 1a, R 1b, R 1c, R 1d and R 1e is independently H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; R u is H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; each R 2a, R 2b and R 2c is independently H, D, F, Cl, Br, I, -CN, -NO 2, -NH 2, -OH, -SH, -COOH, -C(=O)NH 2, -C(=O)NHCH 3, -C(=O)N(CH 3) 2, -C(=O)-(C 1 -C 6 alkyl), -C(=O)-(C 1 -C 6 alkoxy), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl; R 3a is F, Cl, Br, I, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkoxy, C 1 -C 6 haloalkoxy or hydroxy-substituted C 1 -C 6 alkyl; R 3b is H, D, F, Cl, Br, I, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy or hydroxy-substituted C 1 -C 6 alkyl; and each R 4 and R 5 is independently H, D, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl or 5-10 membered heteroaryl, wherein each of the C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylamino, hydroxy-substituted C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, 3-8 membered heterocyclyl, C 6 -C 10 aryl and 5-10 membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from D, F, Cl, Br, I, -OH, -NH 2, -NO 2, -CN, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 3 -C 8 cycloalkyl or C 6 -C 10 aryl.