An ultrasonic surgical instrument, comprising: (a) an end effector configured to actuate from a first configuration to a second configuration, including: (i) an ultrasonic blade configured to selectively apply ultrasonic energy to tissue, and (ii) an RF electrode configured to selectively apply RF energy to tissue; (b) a shaft assembly projecting proximally from the end effector; (c) a body projecting proximally from the shaft assembly, wherein the body includes an energy input operatively connected to the ultrasonic blade; and (d) a controller operatively connected to the ultrasonic blade and the RF electrode, wherein the controller has a memory including a first collection of predetermined termination parameters with a first smaller tissue predetermined termination parameter and a first larger tissue predetermined termination parameter stored thereon, wherein the controller is configured to: activate one or both of the ultrasonic blade or the RF electrode to apply ultrasonic energy or RF energy, respectively, to tissue; identify a relative size of the tissue as a smaller tissue size or a larger tissue size; set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter based on the identified relative size of the tissue; measure a first measured termination parameter of the tissue; and terminate (1326, 1434) one or both of the ultrasonic energy or the RF energy when the first measured termination parameter reaches the set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter to thereby inhibit transecting the tissue. (a) an end effector configured to actuate from a first configuration to a second configuration, including: (i) an ultrasonic blade configured to selectively apply ultrasonic energy to tissue, and (ii) an RF electrode configured to selectively apply RF energy to tissue; (i) an ultrasonic blade configured to selectively apply ultrasonic energy to tissue, and (ii) an RF electrode configured to selectively apply RF energy to tissue; (b) a shaft assembly projecting proximally from the end effector; (c) a body projecting proximally from the shaft assembly, wherein the body includes an energy input operatively connected to the ultrasonic blade; and (d) a controller operatively connected to the ultrasonic blade and the RF electrode, wherein the controller has a memory including a first collection of predetermined termination parameters with a first smaller tissue predetermined termination parameter and a first larger tissue predetermined termination parameter stored thereon, wherein the controller is configured to: activate one or both of the ultrasonic blade or the RF electrode to apply ultrasonic energy or RF energy, respectively, to tissue; identify a relative size of the tissue as a smaller tissue size or a larger tissue size; set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter based on the identified relative size of the tissue; measure a first measured termination parameter of the tissue; and terminate (1326, 1434) one or both of the ultrasonic energy or the RF energy when the first measured termination parameter reaches the set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter to thereby inhibit transecting the tissue. activate one or both of the ultrasonic blade or the RF electrode to apply ultrasonic energy or RF energy, respectively, to tissue; identify a relative size of the tissue as a smaller tissue size or a larger tissue size; set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter based on the identified relative size of the tissue; measure a first measured termination parameter of the tissue; and terminate (1326, 1434) one or both of the ultrasonic energy or the RF energy when the first measured termination parameter reaches the set one of the first smaller tissue predetermined termination parameter or the first larger tissue predetermined termination parameter to thereby inhibit transecting the tissue.