A compound selected from Formula I: and stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R 1 is H, C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, or heteroaryl with 5 to 20 ring atoms; R 2 is H, heterocyclyl with 3 to 20 ring atoms, heteroaryl with 5 to 20 ring atoms, -(heteroaryl with 5 to 20 ring atoms)-(heterocyclyl with 3 to 20 ring atoms), C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, NR 4 R 5 or OR 4; or R 1 and R 2 together form heterocyclyl with 3 to 20 ring atoms or heteroaryl with 5 to 20 ring atoms; X is selected from the structures: where the wavy line indicates the site of attachment; R 3 is H, Cl, Br, C 1 -C 12 alkyl, -(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 2 -C 8 alkenylene)-(C 3 -C 12 carbocyclyl), -(C 2 -C 8 alkenylene)-(heterocyclyl with 3 to 20 ring atoms), C 6 -C 20 aryl, -(C 6 -C 20 arylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 6 -C 20 arylene)-(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, or heteroaryl with 5 to 20 ring atoms; R 4 and R 5 are independently selected from H, C 1 -C 12 alkyl, C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, heteroaryl with 5 to 20 ring atoms, -(C 1 -C 12 alkylene)-(C 6 -C 20 aryl), -(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 1 -C 12 alkylene)-(heteroaryl with 5 to 20 ring atoms); or R 4 and R 5 together form heterocyclyl with 3 to 20 ring atoms or heteroaryl with 5 to 20 ring atoms; R 6 is H or -NH 2; R 7 is H, F, CH 2 F, CHF 2, and CF 3; and where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CH 3,-CH 2 CH 3, -CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 NH 2, -CH 2 CH 2 NH 2, -CH 2 CHCH 2 NH 2,-CH 2 CH(CH 3)NH 2, -CH 2 OH, -CH 2 CH 2 OH, -C(CH 3) 2 OH, -CH CH(CH 3) 2,-C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CN, -CF 3, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3,-COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NO 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3, -N(CH 3)C(CH 3) 2 CONH 2,-N(CH 3)CH 2 CH 2 S 2 CH 3, =O, -OH, -OCH 3, -S 2 N(CH 3) 2, -SCH 3, -CH 2 OCH 3, -S 2 CH 3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino, with proviso that the compound of formula is not and R 1 is H, C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, or heteroaryl with 5 to 20 ring atoms; R 2 is H, heterocyclyl with 3 to 20 ring atoms, heteroaryl with 5 to 20 ring atoms, -(heteroaryl with 5 to 20 ring atoms)-(heterocyclyl with 3 to 20 ring atoms), C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, NR 4 R 5 or OR 4; or R 1 and R 2 together form heterocyclyl with 3 to 20 ring atoms or heteroaryl with 5 to 20 ring atoms; X is selected from the structures: where the wavy line indicates the site of attachment; R 3 is H, Cl, Br, C 1 -C 12 alkyl, -(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 2 -C 8 alkenylene)-(C 3 -C 12 carbocyclyl), -(C 2 -C 8 alkenylene)-(heterocyclyl with 3 to 20 ring atoms), C 6 -C 20 aryl, -(C 6 -C 20 arylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 6 -C 20 arylene)-(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, or heteroaryl with 5 to 20 ring atoms; R 4 and R 5 are independently selected from H, C 1 -C 12 alkyl, C 6 -C 20 aryl, C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, heteroaryl with 5 to 20 ring atoms, -(C 1 -C 12 alkylene)-(C 6 -C 20 aryl), -(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 1 -C 12 alkylene)-(heteroaryl with 5 to 20 ring atoms); or R 4 and R 5 together form heterocyclyl with 3 to 20 ring atoms or heteroaryl with 5 to 20 ring atoms; R 6 is H or -NH 2; R 7 is H, F, CH 2 F, CHF 2, and CF 3; and where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CH 3,-CH 2 CH 3, -CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 NH 2, -CH 2 CH 2 NH 2, -CH 2 CHCH 2 NH 2,-CH 2 CH(CH 3)NH 2, -CH 2 OH, -CH 2 CH 2 OH, -C(CH 3) 2 OH, -CH CH(CH 3) 2,-C(CH 3) 2 CH 2 OH, -CH 2 CH 2 SO 2 CH 3, -CN, -CF 3, -CO 2 H, -COCH 3, -CO 2 CH 3, -CO 2 C(CH 3) 3,-COCH CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NO 2, -NH 2,-NHCH 3, -N(CH 3) 2, -NHCOCH 3, -N(CH 3)COCH 3, -NHS 2 CH 3, -N(CH 3)C(CH 3) 2 CONH 2,-N(CH 3)CH 2 CH 2 S 2 CH 3, =O, -OH, -OCH 3, -S 2 N(CH 3) 2, -SCH 3, -CH 2 OCH 3, -S 2 CH 3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino, with proviso that the compound of formula is not and