A compound of general formula I wherein D is a cycloalkylene, heterocycloalkylene or heteroarylene group selected from D0-D8 wherein at least one of X1, X2, X3 and X4 is at each occurrence independently selected from N, NR 7, O, S and the others are CH groups; in such a way that: D is selected from cycloalkylene D0 which is cyclohexanediyl, or D is heterocycloalkylene selected from D1 which is piperidin-diyl, pyrrolidine-diyl, D2 which is tetrahydropyridin-diyl, 1H-dihydropyrrolediyl or D is heteroarylene selected from D3 which is furane-diyl, thiophene-diyl, pyrazolediyl, thiazole-diyl, oxazole-diyl, D4 which is pyrazolediyl, D5 which is pyridinediyl, pyrimidinediyl, pyrazinediyl or pyridazinediyl, D6 which is pyridinediyl, pyrimidinediyl or pyrazinediyl, D7 which is pyridinediyl, pyrimidinediyl or pyrazinediyl, D8 which is tetrahydrothienopyridin-diyl; Y is a divalent group of formula wherein: A2 is absent or methylene and A1 is independently selected from (C 1 -C 12)alkylene which is methylene, ethylene, n-propylene, butylene, isobutylene, pentylene, hexylene, heptylene, octylene; B is absent or is selected from (C 3 -C 8)heterocycloalkylene which is piperidinylene or indanediyl, arylene which is phenylene and heteroarylene which is thiophenediyl or pyridine-diyl; B being optionally substituted by one or more groups selected independently from -OH, halogen which is fluorine, chlorine, bromine, (C 1 -C 6)alkyl which is methyl, (C 1 -C 6)alkoxy which is methoxy, ethoxy, isopropoxy, (C 1 -C 6)haloalkyl which is trifluoromethyl and (C 1 -C 6)haloalkoxy which is trifluoromethoxy; C is selected from -C -, or is one of the following groups C1-C5 wherein R 7 is H or or methyl; and Rs is H or methyl; t, t ' and n ' are 1; n is 0 or 1; G is arylene which is meta-phenylene or para-phenylene; L is a bond or (C 1 -C 8)alkylene which is -CH(CH 3)- or -(CH 2)-; R 2 is a group of formula J1, J2, J3, J4, J5, J6, J7 or J8 v and v' are at each occurrence independently 1 or 2; Rs is a group of formula K wherein p is 0 or 1; q is 0; P is absent W is selected from (C 1 -C 6)alkyl which is methyl, (C 3 -C 8)cycloalkyl which is cyclobutyl or cyclopentyl, aryl which is phenyl optionally substituted by (C 1 -C 10)alkoxy which is methoxy; R 9 is in each occurrence independently H or (C 1 -C 8)alkyl which is methyl; and pharmaceutically acceptable salts or solvates thereof. D is selected from cycloalkylene D0 which is cyclohexanediyl, or D is heterocycloalkylene selected from D1 which is piperidin-diyl, pyrrolidine-diyl, D2 which is tetrahydropyridin-diyl, 1H-dihydropyrrolediyl or D is heteroarylene selected from D3 which is furane-diyl, thiophene-diyl, pyrazolediyl, thiazole-diyl, oxazole-diyl, D4 which is pyrazolediyl, D5 which is pyridinediyl, pyrimidinediyl, pyrazinediyl or pyridazinediyl, D6 which is pyridinediyl, pyrimidinediyl or pyrazinediyl, D7 which is pyridinediyl, pyrimidinediyl or pyrazinediyl, D8 which is tetrahydrothienopyridin-diyl; Y is a divalent group of formula A2 is absent or methylene and A1 is independently selected from (C 1 -C 12)alkylene which is methylene, ethylene, n-propylene, butylene, isobutylene, pentylene, hexylene, heptylene, octylene; B is absent or is selected from (C 3 -C 8)heterocycloalkylene which is piperidinylene or indanediyl, arylene which is phenylene and heteroarylene which is thiophenediyl or pyridine-diyl; B being optionally substituted by one or more groups selected independently from -OH, halogen which is fluorine, chlorine, bromine, (C 1 -C 6)alkyl which is methyl, (C 1 -C 6)alkoxy which is methoxy, ethoxy, isopropoxy, (C 1 -C 6)haloalkyl which is trifluoromethyl and (C 1 -C 6)haloalkoxy which is trifluoromethoxy; C is selected from -C -, or is one of the following groups C1-C5 R 7 is H or or methyl; and Rs is H or methyl; t, t ' and n ' are 1; n is 0 or 1; G is arylene which is meta-phenylene or para-phenylene; L is a bond or (C 1 -C 8)alkylene which is -CH(CH 3)- or -(CH 2)-; R 2 is a group of formula J1, J2, J3, J4, J5, J6, J7 or J8 v and v' are at each occurrence independently 1 or 2; Rs is a group of formula K wherein p is 0 or 1; q is 0; P is absent W is selected from (C 1 -C 6)alkyl which is methyl, (C 3 -C 8)cycloalkyl which is cyclobutyl or cyclopentyl, aryl which is phenyl optionally substituted by (C 1 -C 10)alkoxy which is methoxy; R 9 is in each occurrence independently H or (C 1 -C 8)alkyl which is methyl; and pharmaceutically acceptable salts or solvates thereof.