mhurhangee/ep-ind-claims huggingface dataset:
A compound of any one of formulae (IIA-1), (IIA-2), (IIB-1) or (IIB-2), or an N -oxide thereof, or a pharmaceutically acceptable salt thereof: wherein W represents N, CH or CF; R 2 represents hydrogen or halogen; R 5 represents difluoromethoxy or -OR a; R 6 represents hydrogen, halogen or trifluoromethyl; R 7 and R 8 independently represent hydrogen or trifluoromethyl; R 9 represents hydroxy(C 1-6)alkyl or amino(C 1-6)alkyl; R 10 represents hydrogen or C 1-6 alkyl; R 11 represents a group of formula (a), (b), (c), (d), (e), (f) or (g): in which the asterisk (*) represents the site of attachment to the remainder of the molecule; U represents O, N(R 31) or C(R 32)(R 33); R 31 represents hydrogen or C 1-6 alkyl; R 32 represents hydrogen, C 1-6 alkyl or hydroxyl(C 1-6)alkyl; R 33 represents hydrogen, halogen, C 1-6 alkyl, difluoromethyl, trifluoromethyl,, hydroxy(C 1-6)alkyl, or amino; R 34 represents hydrogen, cyano or amino; R 35 represents hydrogen or C 1-6 alkyl; R 36 and R 37 independently represent C 1-6 alkyl; or R 36 and R 37, when taken together with the carbon atom to which they are both attached, represent C 3-7 cycloalkyl; R a represents C 1-6 alkyl, aryl(C 1-6)alkyl or heteroaryl(C 1-6)alkyl, any of which groups may be optionally substituted by one or more substituents selected from C 1-6 alkoxy and oxo; R f represents hydrogen; or R f represents C 1-6 alkyl optionally substituted with one, two or three substitutents independently selected from hydroxyl and carboxy. W represents N, CH or CF; R 2 represents hydrogen or halogen; R 5 represents difluoromethoxy or -OR a; R 6 represents hydrogen, halogen or trifluoromethyl; R 7 and R 8 independently represent hydrogen or trifluoromethyl; R 9 represents hydroxy(C 1-6)alkyl or amino(C 1-6)alkyl; R 10 represents hydrogen or C 1-6 alkyl; R 11 represents a group of formula (a), (b), (c), (d), (e), (f) or (g): in which the asterisk (*) represents the site of attachment to the remainder of the molecule; U represents O, N(R 31) or C(R 32)(R 33); R 31 represents hydrogen or C 1-6 alkyl; R 32 represents hydrogen, C 1-6 alkyl or hydroxyl(C 1-6)alkyl; R 33 represents hydrogen, halogen, C 1-6 alkyl, difluoromethyl, trifluoromethyl,, hydroxy(C 1-6)alkyl, or amino; R 34 represents hydrogen, cyano or amino; R 35 represents hydrogen or C 1-6 alkyl; R 36 and R 37 independently represent C 1-6 alkyl; or R 36 and R 37, when taken together with the carbon atom to which they are both attached, represent C 3-7 cycloalkyl; R a represents C 1-6 alkyl, aryl(C 1-6)alkyl or heteroaryl(C 1-6)alkyl, any of which groups may be optionally substituted by one or more substituents selected from C 1-6 alkoxy and oxo; R f represents hydrogen; or R f represents C 1-6 alkyl optionally substituted with one, two or three substitutents independently selected from hydroxyl and carboxy.
Method for producing a chip-generating cutting tool which is a solid milling cutter and comprises a substrate which is made of carbide or cermet and is at least partially coated with a coating, wherein the cutting tool has at least one rake surface and at least one flank surface, between which at least one cutting edge (62.1) is arranged, wherein at least one segment of the at least one cutting edge (62.1) is formed by the coating and therefore forms a coated cutting-edge segment, wherein, at each point of the coated cutting-edge segment at least within a segment region of the coated cutting-edge segment, a quotient made up of a radius of the coated cutting-edge segment at the respective point divided by a local thickness of the coating is smaller than 0.9, characterized in that the substrate is coated with the coating, wherein, so that, at each point of the coated cutting-edge segment at least within the segment region of the coated cutting-edge segment, the quotient made up of the radius of the coated cutting-edge segment at the respective point divided by the local thickness of the coating is smaller than 0.9, the cutting tool has a cutting part with a diameter and the coating is applied with an average thickness, in that the diameter of the cutting part is greater than the average thickness of the coating by a factor of at most 600, preferably at most 300, particularly preferably at most 100, wherein the average thickness is an average of the thickness of the coating in a region of the at least one flank surface which butts against the segment region, said region butting against the segment region over the entire segment region of the coated cutting-edge segment, as a result of which, following the application of the coating, part of the coating of the cutting edge (62.1) chips away and thus forms a new cutting edge (62.1), wherein a site of rupture, at which the part of the coating has chipped away, forms a new rake surface, as a result of which, at each point of the coated cutting-edge segment within the segment region of the coated cutting-edge segment, the quotient made up of the radius of the coated cutting-edge segment at the respective point divided by the local thickness of the coating is smaller than 0.9, wherein the segment region of the coated cutting-edge segment extends over at least 80% of the coated cutting-edge segment.
A gastric implant system including: a gastric implant; an anchor having a distal portion engageable with abdominal wall tissue within a living body, and a proximal section including an elongate member and proportioned to extend from the distal portion, through a stomach wall and into a stomach when the distal portion is engaged with abdominal wall tissue; and a locking element coupled to the proximal section of the anchor, the locking element including a collar slidable on the elongate member and having an unlocked position in which the locking element is moveable relative to the anchor into a position in abutment with an interior surface of a stomach wall, and a locked position in which the locking element engages a portion of the anchor; and a detachable spacer between the collar and the distal portion of the anchor. a gastric implant; an anchor having a distal portion engageable with abdominal wall tissue within a living body, and a proximal section including an elongate member and proportioned to extend from the distal portion, through a stomach wall and into a stomach when the distal portion is engaged with abdominal wall tissue; and a locking element coupled to the proximal section of the anchor, the locking element including a collar slidable on the elongate member and having an unlocked position in which the locking element is moveable relative to the anchor into a position in abutment with an interior surface of a stomach wall, and a locked position in which the locking element engages a portion of the anchor; and a detachable spacer between the collar and the distal portion of the anchor.
Method for controlling a shift operation of an automatic-shift transmission in a vehicle with a combustion machine as engine, wherein, in a control unit, a shift strategy is specified in which the behaviour of the engine after a possible shift process into a target gear ratio is continuously ascertained predictively on the basis of presently detected actual driving dynamics and/or vehicle-specific and/or engine-specific values, wherein shift thresholds adapted in a manner incorporating these predictive results are ascertained and specified as upshift thresholds or downshift thresholds, and wherein, after overshooting of a shift threshold, a control command for a corresponding automatic shift operation is output, wherein the present temperature of at least one component of the engine exhaust-gas system is jointly taken into consideration in the specification of an adapted shift threshold, characterized in that, in the predictive ascertainment of the behaviour of the combustion machine, a torque build-up as a load step response (13 to 17) of the combustion machine after a shift operation is pre-calculated in a manner incorporating the present temperature (7; 9) of at least one component of the engine exhaust-gas system, and in that, in the specification of a shift threshold and in a decision for a shift operation, it is taken into consideration how quickly, and with what profile with respect to time in the presence of the present temperature condition, the combustion machine provides the power required for the present speed demand of the vehicle.
Method for manufacturing a composition, characterised by bringing into contact the following three components: - a product containing mostly polypropylene having a controlled fluidity according to standard ISO 1133 (230 °C, 2.16 kg) less than 10 g/10 min, present in an amount from 82 % to 88 % inclusive, by total weight of the composition, - polypropylene having a controlled fluidity according to standard ISO 1133 (230 °C, 2.16 kg) greater than 400 g/10 min, present in an amount from 7 % to 13 % inclusive, by total weight of the composition, and - a polymer grafted with maleic anhydride, present in an amount from 2 % to 8 % inclusive, by total weight of the composition. - a product containing mostly polypropylene having a controlled fluidity according to standard ISO 1133 (230 °C, 2.16 kg) less than 10 g/10 min, present in an amount from 82 % to 88 % inclusive, by total weight of the composition, - polypropylene having a controlled fluidity according to standard ISO 1133 (230 °C, 2.16 kg) greater than 400 g/10 min, present in an amount from 7 % to 13 % inclusive, by total weight of the composition, and - a polymer grafted with maleic anhydride, present in an amount from 2 % to 8 % inclusive, by total weight of the composition.
A gas turbine engine comprising: a fan section including a fan with a plurality of fan blades rotatable about an axis, each of the plurality of fan blades includes a mid-span shroud including a first shroud member on a first side of each of the fan blades having a first bearing face on a distal end and a second shroud member on a second opposite side of each of the fan blades having a second bearing face on a distal end; the first bearing face and the second bearing face are sized to withstand the reaction forces from adjacent fan blades during operation of the gas turbine engine; the first and second shroud members (68, 70) contact each other at approximately the midpoint between adjacent fan blades; characterised in that the first and second shroud members (68, 70) include an elliptical cross section, wherein a cross-sectional area of the second bearing face is greater than a cross-sectional area of a mid-portion of the second shroud member, a minor axis of the elliptical cross-section varies along the length of the mid-span shroud, a major axis of the elliptical cross section is constant along the length of the mid-span shroud, and a cross-sectional area of the mid-span shroud decreases between opposing ends of the mid-span shroud; and the engine further comprises a speed change device in communication with the fan. a fan section including a fan with a plurality of fan blades rotatable about an axis, each of the plurality of fan blades includes a mid-span shroud including a first shroud member on a first side of each of the fan blades having a first bearing face on a distal end and a second shroud member on a second opposite side of each of the fan blades having a second bearing face on a distal end; the first bearing face and the second bearing face are sized to withstand the reaction forces from adjacent fan blades during operation of the gas turbine engine; the first and second shroud members (68, 70) contact each other at approximately the midpoint between adjacent fan blades; characterised in that the first and second shroud members (68, 70) include an elliptical cross section, wherein a cross-sectional area of the second bearing face is greater than a cross-sectional area of a mid-portion of the second shroud member, a minor axis of the elliptical cross-section varies along the length of the mid-span shroud, a major axis of the elliptical cross section is constant along the length of the mid-span shroud, and a cross-sectional area of the mid-span shroud decreases between opposing ends of the mid-span shroud; and the engine further comprises a speed change device in communication with the fan.
Connector bridge for an electrical device connector for connecting electrical devices, in particular household appliances, to a plug socket of an alternating current network, the device connector being formed as a unit by the connector bridge which is connected to the end piece of a three-core connection cable for the device and which is extrusion-coated in an injection mould, and which is itself constructed from a dimensionally stable insulation member for receiving and fixing a rectangular phase conductor pin, rectangular neutral conductor pin and rectangular earth conductor pin, the phase, neutral and earth conductor pins (3a, b, c) also being injection moulded in/on in the same operating step as the injection moulding of the insulation member in openings of the insulation member corresponding to the cross-section thereof, the phase, neutral and earth conductor pins (3a, b, c) projecting relative to the connector bridge and the device connector to a sufficient extent to be introduced into the plug socket, the phase conductor pin, neutral conductor pin and earth conductor pin each having inclined introduction members, the phase conductor pin and neutral conductor pin each having insulation at the insulation member side and the phase conductor pin, neutral conductor pin and earth conductor pin each being in the form of a folding pin which is drawn into its definitive spatial shape from an initially flat punched component comprising metal sheet, is folded and is filled with plastics material in its empty and intermediate spaces during the injection moulding process of the insulation member in such a manner that, after the injection moulding process, the phase, neutral and earth conductor pins (3a, b, c) have the definitive contour thereof, characterised in that, after the connector bridge has been extrusion-coated, at the plug socket side all the surfaces of the phase, neutral and earth conductor pins (3a, b, c) produced in that manner, including the inclined introduction members, at least as far as the insulation at the insulation member side comprise the metal sheet, in that the phase, neutral and earth conductor pins (3b, c, a) have projections and cut-outs at the folding seams, with the projections coming to rest in a deformed state in the cut-outs during the folding operation and consequently allowing a positive-locking and non-positive-locking connection, in that a large number of sheet metal strips are punched out of the long metal sheet, with a web remaining at the centre of the transverse axis and forming the connector-side end of the phase, neutral and earth conductor pins (3a, b, c) after the folding operation.
Fitting for a sliding door, in particular a lift-and-slide door, having a locking mechanism which has a locking bolt and a locking element which can be brought into engagement with the locking bolt, wherein the locking bolt projects in a locked position from a frame profile (20, 30) and engages in the locking element, wherein the locking bolt is movable in an unlocked position from the position projecting from the frame profile (20, 30) into a retracted position, characterized in that a blocking element is provided which blocks actuation of a sliding door lock when the locking bolt is in a retracted position, wherein the blocking element is coupled to the locking bolt in the retracted position thereof and the blocking element is decoupled only in the extended position of the locking bolt to unlock an actuating element (15, 6') for the sliding door.
An apparatus for introducing a sample into a separation unit of a chromatography system with a mobile phase, the mobile phase comprising a first mobile phase component and a second mobile phase component, the apparatus comprising: a first pump system configured to provide the first mobile phase component to a branching path, such that a first portion of the first mobile phase component flows through a first branch, and a second portion of the first mobile phase component flows through a second branch, wherein relative levels of branch restriction dictate the amount of the first mobile phase component that flows through each of the first and second branches; a second pump system configured to provide the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch; and an injection unit configured to receive a combined stream, comprising the first portion of the first mobile phase component provided via the first branch and the first portion of the second mobile phase component provided via the third branch, and to inject a sample solution into the combined stream to form a sample-containing stream, wherein the sample-containing stream is subsequently combined with at least the second portion of the first mobile phase component provided via the second branch to form a diluted sample-containing stream, which flows to the separation unit of the chromatography system for separating sample constituents. a first pump system configured to provide the first mobile phase component to a branching path, such that a first portion of the first mobile phase component flows through a first branch, and a second portion of the first mobile phase component flows through a second branch, wherein relative levels of branch restriction dictate the amount of the first mobile phase component that flows through each of the first and second branches; a second pump system configured to provide the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch; and an injection unit configured to receive a combined stream, comprising the first portion of the first mobile phase component provided via the first branch and the first portion of the second mobile phase component provided via the third branch, and to inject a sample solution into the combined stream to form a sample-containing stream, wherein the sample-containing stream is subsequently combined with at least the second portion of the first mobile phase component provided via the second branch to form a diluted sample-containing stream, which flows to the separation unit of the chromatography system for separating sample constituents.
A screen calibration method comprising: acquiring a full screen image displayed on a screen Z comprising a plurality of regions by a camera to generate an acquired full screen image; acquiring first optical data of a first region of the screen by a sensor close to the screen and configured to acquire first optical data of the first region of the screen, wherein the first optical data acquired from the sensor is equivalent to a real luminous characteristic of the first region without introducing an ambient light signal;; generating first calibration parameters according to target optical data and the first optical data; calibrating colors of the first region of the screen according to first calibration parameters to approach target optical data; the method being characterized by further comprising: determining a set of ambient light parameters for the first region according to the full screen image and the first optical data; estimating second optical data of a second region according to the acquired full screen image and the set of ambient light parameters for the first region; generating second calibration parameters according to the target optical data and the second optical data; and calibrating colors of the second region of the screen according to the second calibration parameters to approach the target optical data. acquiring a full screen image displayed on a screen Z comprising a plurality of regions by a camera to generate an acquired full screen image; acquiring first optical data of a first region of the screen by a sensor close to the screen and configured to acquire first optical data of the first region of the screen, wherein the first optical data acquired from the sensor is equivalent to a real luminous characteristic of the first region without introducing an ambient light signal;; generating first calibration parameters according to target optical data and the first optical data; calibrating colors of the first region of the screen according to first calibration parameters to approach target optical data; the method being characterized by further comprising: determining a set of ambient light parameters for the first region according to the full screen image and the first optical data; estimating second optical data of a second region according to the acquired full screen image and the set of ambient light parameters for the first region; generating second calibration parameters according to the target optical data and the second optical data; and calibrating colors of the second region of the screen according to the second calibration parameters to approach the target optical data. determining a set of ambient light parameters for the first region according to the full screen image and the first optical data; estimating second optical data of a second region according to the acquired full screen image and the set of ambient light parameters for the first region; generating second calibration parameters according to the target optical data and the second optical data; and calibrating colors of the second region of the screen according to the second calibration parameters to approach the target optical data.
Composition comprising a blend of 90 - 99wt%, based on the blend, of a random propylene copolymer having a melt flow rate (MFR 230°C/2.16kg) of 15 - 40 g/10min and containing 1.5 - 2.5wt% ethylene, and 1 - 10 wt%, based on the blend, of an ethylene based plastomer having a density of 860 - 915 kg/m 3 and an MI 2 (190°C/2.16kg) of 0.5 to 25 g/10 min, wherein the composition has a flexural modulus of 700 - 1300 MPa, determined as disclosed in the description. 90 - 99wt%, based on the blend, of a random propylene copolymer having a melt flow rate (MFR 230°C/2.16kg) of 15 - 40 g/10min and containing 1.5 - 2.5wt% ethylene, and 1 - 10 wt%, based on the blend, of an ethylene based plastomer having a density of 860 - 915 kg/m 3 and an MI 2 (190°C/2.16kg) of 0.5 to 25 g/10 min, wherein the composition has a flexural modulus of 700 - 1300 MPa, determined as disclosed in the description.
5'-adenosine diphosphate ribose (ADPR), or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, stereoisomer, isotopologue, or polymorph thereof for use in a method for treating, managing, or preventing an RNA virus-related disease or condition in a patient, said method comprising administering to the patient an effective amount of ADPR, or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, stereoisomer, isotopologue, or polymorph thereof; wherein the patient has or is at risk of developing an RNA virus-related disease or condition; wherein the RNA virus-related disease or condition is caused by an human respiratory syncytial virus (HRSV).
Composition consisting of from 80% to 90% of dimethyl sulfoxide (DMSO), from 2% to 9% of monoethanolamine (MEoA) and from 5% to 15%, for example approximately 8%, of water, and optionally from a few ppm by weight to 1% of a corrosion inhibitor.