A process for preparation of stacked, patterned biomaterials and/or tissue engineering 3D scaffolds with different dimensions and designs, both physical and chemical, with respect to the orientation of lamellae, and different size surface features and multilamellar structure of different thickness and characterized by the steps of; • Preparation of solutions of collagen, with different concentrations, • Pouring collagen solution onto patterned templates, wherein the patterned templates are produced on silicon wafers by photolithography, and wherein the template structure is of any topographical feature, such as ridges or grooves connected by inclined surfaces of any inclination degree and varying ridge and groove dimensions, and the designs on the temptates is at nano or micro level, and wherein the template structure is any type of micropattern such as cobblestone, pillar, 2D stripes, square, circular, and could be obtained either by photolithography or for nanoscale patterning, by electron beam lithography or interference lithography or embossing, or contact printing or AFM based lithography to accommodate the necessities of any 3D design, and • Producing film structures which have same or inverse surface patterns of the template by solvent casting, • drying and peeling off the collagen films formed on the micropatterned templates • Carrying out a crosslinking procedure to stabilize the films, • Washing the films, • Achieving the attachment of several crosslinked films to each other, wherein the number of adhesion/contact points, the relative orientation of the surface topographical features, size and geometry of the features, dimensions of each film layer and number of layers is adjusted during the manufacturing process according to the specific requirements of the target tissue. • Preparation of solutions of collagen, with different concentrations, • Pouring collagen solution onto patterned templates, wherein the patterned templates are produced on silicon wafers by photolithography, and wherein the template structure is of any topographical feature, such as ridges or grooves connected by inclined surfaces of any inclination degree and varying ridge and groove dimensions, and the designs on the temptates is at nano or micro level, and wherein the template structure is any type of micropattern such as cobblestone, pillar, 2D stripes, square, circular, and could be obtained either by photolithography or for nanoscale patterning, by electron beam lithography or interference lithography or embossing, or contact printing or AFM based lithography to accommodate the necessities of any 3D design, and • Producing film structures which have same or inverse surface patterns of the template by solvent casting, • drying and peeling off the collagen films formed on the micropatterned templates • Carrying out a crosslinking procedure to stabilize the films, • Washing the films, • Achieving the attachment of several crosslinked films to each other, wherein the number of adhesion/contact points, the relative orientation of the surface topographical features, size and geometry of the features, dimensions of each film layer and number of layers is adjusted during the manufacturing process according to the specific requirements of the target tissue.