A compound according the following Formula, or its stereoisomers or tautomers, or pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, wherein X is N; Y is N-R 5, O, or absent; R 1 is L 1 -R 6, L 1 -R 6 -L 2 -R 7; R 2 is H, Hal, OH, OA, CN, NH 2, or NHA; R 3 is H, CH 3, or C(Hal) 3; R 4 is H, Hal, OH, COOH, NH 2, or CN; R 5 is H, LA or monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by a -NH- group, or R 5, R 1 together form monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NA-, -N(L 1 -R 6)-, -CHA-, -CA 2 -, CH(L 1 -R 6)- or -CO- group, and which monocyclic alkyl may be substituted by NH 2; L 1, L 2 are independently a single bond, or unbranched or branched alkyl having 1, 2, 3, 4 or 5 C atoms, which may be unsubstituted, or mono- or disubstituted with Hal, OH, NH 2, NH, N 2, and wherein one or two CH 2 groups may be replaced by an O atom or by a -CO-, -NH-, -N -, -CONH-, -N COO- or -NHCO-group; R 6 is Ar or monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NA-, -CHA-, -CO- or -CONHA- group; R 7 is phenyl, which is unsubstituted, or independently mono-, di- or trisubstituted by Hal, C(Hal) 3, CH 3, CH 3 O, C(Hal) 3 O, Ar is a mono- or bicyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, O and/or S atoms and 5, 6, 8, 9, or 10 skeleton atoms, which may be unsubstituted or, indenpendently of one another, mono-, di- or trisubstituted by Hal, A, OA, OH, NH 2, or NHA; A is an unbranched or branched linear or cyclic alkyl having 1, 2, 3, 4, 5 or 6 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NHCOAr or -CONHAr group in which 1-3 H atoms may be replaced by Hal, and in which one or two CH 3 groups may be replaced by NH 2, OH, NH or N 2 group; LA is unbranched or branched, linear alkyl having 1, 2, 3, or 4 C atoms wherein 1, 2 or 3 H atoms may be replaced by Hal (e.g., methyl, ethyl, and trifluoromethyl); and Hal is F, Cl, Br or I. X is N; Y is N-R 5, O, or absent; R 1 is L 1 -R 6, L 1 -R 6 -L 2 -R 7; R 2 is H, Hal, OH, OA, CN, NH 2, or NHA; R 3 is H, CH 3, or C(Hal) 3; R 4 is H, Hal, OH, COOH, NH 2, or CN; R 5 is H, LA or monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by a -NH- group, or R 5, R 1 together form monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NA-, -N(L 1 -R 6)-, -CHA-, -CA 2 -, CH(L 1 -R 6)- or -CO- group, and which monocyclic alkyl may be substituted by NH 2; L 1, L 2 are independently a single bond, or unbranched or branched alkyl having 1, 2, 3, 4 or 5 C atoms, which may be unsubstituted, or mono- or disubstituted with Hal, OH, NH 2, NH, N 2, and wherein one or two CH 2 groups may be replaced by an O atom or by a -CO-, -NH-, -N -, -CONH-, -N COO- or -NHCO-group; R 6 is Ar or monocyclic alkyl having 3, 4, 5, 6, or 7 ring atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NA-, -CHA-, -CO- or -CONHA- group; R 7 is phenyl, which is unsubstituted, or independently mono-, di- or trisubstituted by Hal, C(Hal) 3, CH 3, CH 3 O, C(Hal) 3 O, Ar is a mono- or bicyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, O and/or S atoms and 5, 6, 8, 9, or 10 skeleton atoms, which may be unsubstituted or, indenpendently of one another, mono-, di- or trisubstituted by Hal, A, OA, OH, NH 2, or NHA; A is an unbranched or branched linear or cyclic alkyl having 1, 2, 3, 4, 5 or 6 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or an -NH-, -NHCOAr or -CONHAr group in which 1-3 H atoms may be replaced by Hal, and in which one or two CH 3 groups may be replaced by NH 2, OH, NH or N 2 group; LA is unbranched or branched, linear alkyl having 1, 2, 3, or 4 C atoms wherein 1, 2 or 3 H atoms may be replaced by Hal (e.g., methyl, ethyl, and trifluoromethyl); and Hal is F, Cl, Br or I.