mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing a transgenic Bombyx mori silkworm capable of expressing a stable chimeric spider silk protein suitable for assembly into a spider silk composite fiber, said chimeric spider silk protein encoded by a sequence comprising a spider silk flexibility motif sequence and a spider silk strength motif sequence, said method comprising: a.) inserting a piggyBac vector as defined in FIG. 15 or FIG. 16, each having a recombinant genetic cassette encoding a combination of a spider silk flexibility motif sequence and a spider silk strength motif sequence defined by 14 repeated subunits, each subunit having 8 copies of a putative flagelliform silk elastic motif GPGGA and a putative dragline silk strength motif GGPSGPGS 8, into a mutant Bombyx mori egg to provide injected Bombyx mori eggs; b.) allowing the eggs to hatch under suitable incubation conditions to provide larvae; c.) permitting the larvae to mature under suitable incubation conditions; and d.) selecting transgenic Bombyx mori silkworm. a.) inserting a piggyBac vector as defined in FIG. 15 or FIG. 16, each having a recombinant genetic cassette encoding a combination of a spider silk flexibility motif sequence and a spider silk strength motif sequence defined by 14 repeated subunits, each subunit having 8 copies of a putative flagelliform silk elastic motif GPGGA and a putative dragline silk strength motif GGPSGPGS 8, into a mutant Bombyx mori egg to provide injected Bombyx mori eggs; b.) allowing the eggs to hatch under suitable incubation conditions to provide larvae; c.) permitting the larvae to mature under suitable incubation conditions; and d.) selecting transgenic Bombyx mori silkworm.
A pharmaceutical composition consisting of: Astragalus Astragalosides and Glycyrrhiza Acid, for use in treating liver fibrosis in a subject, comprising administering orally a therapeutically effective amount of said pharmaceutical composition to the subject.
A method for executing a client-server application on a mobile device, comprising: receiving from a server a script for execution on the mobile device; receiving a digital certificate issued to the server; verifying the digital certificate and confirming that the script has not been modified since the digital certificate was created; determining whether the server has been granted permission to access a requested resource based on the digital certificate issued to the server; enabling the script to access the resource identified in the digital certificate used to verify the script only if the server has been granted permission to access the requested resource; and transmitting some or all confidential data related to the identified resource to the server. receiving from a server a script for execution on the mobile device; receiving a digital certificate issued to the server; verifying the digital certificate and confirming that the script has not been modified since the digital certificate was created; determining whether the server has been granted permission to access a requested resource based on the digital certificate issued to the server; enabling the script to access the resource identified in the digital certificate used to verify the script only if the server has been granted permission to access the requested resource; and transmitting some or all confidential data related to the identified resource to the server.
A laminated facial mask sheet comprising a liquid-retention layer which comprises a first nonwoven structural member comprising a first fiber and has an ability to absorb a liquid component, wherein the first fiber comprises a hydrophilic resin fiber, and an adhesion layer contactable with a skin, wherein the adhesion layer is formed on one side of the liquid-retention layer and is permeable to the liquid component, wherein the adhesion layer comprises a second nonwoven structural member comprising a second fiber, and the second fiber has a number-average fiber diameter of not more than 10 μm, wherein the thickness ratio of the adhesion layer relative to the liquid-retention layer is 1/4 to 1/100 as a ratio of the adhesion layer/the liquid-retention layer, and wherein the laminated facial mask sheet is impregnated with a cosmetic preparation as the liquid component, wherein the number-average fiber diameter is measured by using a scanning electron microscope with 1000x magnification according to the described method, and wherein the thickness is measured by using a digital microscope according to the described method.
ITE-hearing aid for insertion into an auditory canal of a user with - a housing which has an end wall and a side wall, said side wall in the inserted state being oriented towards an inner wall of the auditory canal and in the inserted state at least partially resting against the inner wall of the auditory canal of the user, - a microphone arranged in the housing, - a sound opening arranged on the end wall of the housing for transmitting sound to the microphone, wherein - the sound opening is connected to the microphone via a sound channel, characterized in that the sound channel is formed at least partially by a lateral recess in the side wall of the housing. - a housing which has an end wall and a side wall, said side wall in the inserted state being oriented towards an inner wall of the auditory canal and in the inserted state at least partially resting against the inner wall of the auditory canal of the user, - a microphone arranged in the housing, - a sound opening arranged on the end wall of the housing for transmitting sound to the microphone, wherein - the sound opening is connected to the microphone via a sound channel,
A method for performing synchronization and compensating clock drift among a plurality of communication devices (110, 120) interconnected to form a mesh communications network (100; 200), wherein a given communication device performs the steps of: - obtaining a first correction information derived at least from a difference between a clock timing resulting from a first distributed consensus-based synchronization and a reference clock timing, the first distributed consensus-based synchronization being performed by all said communication devices, except said given communication device; - transmitting the first correction information through the mesh communications network, the transmitted first correction information aiming all said communication devices, except said given communication device, at updating the clock timing resulting from the first distributed consensus-based synchronization. - obtaining a first correction information derived at least from a difference between a clock timing resulting from a first distributed consensus-based synchronization and a reference clock timing, the first distributed consensus-based synchronization being performed by all said communication devices, except said given communication device; - transmitting the first correction information through the mesh communications network, the transmitted first correction information aiming all said communication devices, except said given communication device, at updating the clock timing resulting from the first distributed consensus-based synchronization.
A carrier assembly comprising: a support frame having an inner frame edge that defines a window of the support frame; an adapter plate coupled to the support frame and positioned within the window, the adapter plate including a plate body having an inner plate edge that defines a pocket configured to receive a substrate that is sized smaller than the window, the inner plate edge also defining a holding recess that opens to the pocket; and a movable datum block positioned within the holding recess, the datum block being movable between a retracted position and an engaged position, the datum block configured to engage the substrate when the datum block is in the engaged position and press the substrate against an opposing surface of the adapter plate to hold the substrate within the pocket. a support frame having an inner frame edge that defines a window of the support frame; an adapter plate coupled to the support frame and positioned within the window, the adapter plate including a plate body having an inner plate edge that defines a pocket configured to receive a substrate that is sized smaller than the window, the inner plate edge also defining a holding recess that opens to the pocket; and a movable datum block positioned within the holding recess, the datum block being movable between a retracted position and an engaged position, the datum block configured to engage the substrate when the datum block is in the engaged position and press the substrate against an opposing surface of the adapter plate to hold the substrate within the pocket.
A crutch, comprising a leg and a main body, said main body, comprising: an arm rest support having a front end and a rear end, the front end having an opening formed in a front face thereof; and a handle extending outwardly from the front end of the arm rest support, characterized in that the leg is received in the opening of the front end of the arm rest support, the leg comprising a first angled section and a second substantially vertical section, the first angled section and the second substantially vertical section being of a unitary configuration, wherein the first angled section is received into the opening in the front end, and wherein the handle does not extend from the opening in the front end in which the leg is received. an arm rest support having a front end and a rear end, the front end having an opening formed in a front face thereof; and a handle extending outwardly from the front end of the arm rest support, the leg is received in the opening of the front end of the arm rest support, the leg comprising a first angled section and a second substantially vertical section, the first angled section and the second substantially vertical section being of a unitary configuration, wherein the first angled section is received into the opening in the front end, and wherein the handle does not extend from the opening in the front end in which the leg is received.
Wall covering having a relief and formed from a plurality of strips applied to a wall next to one another, wherein each of said strips comprises a base, a layer of heat-expandable material applied to said base, wherein this layer has a pattern of expanded and less expanded or unexpanded locations, characterized in that said pattern is different for each strip, wherein said different patterns create a relief pattern in said wall covering exceeding the width of one single strip and extending across various strips.
An ablation device, comprising: a reusable handle assembly including a first electrical contact; and a limited-use needle electrode assembly releasably engagable with the reusable handle assembly, the limited-use needle electrode assembly including a second electrical contact within the needle assembly configured to electrically couple to the first electrical contact to establish electrical communication between the reusable handle assembly and the limited-use needle electrode assembly, the second electrical contact movable from a first position, within the needle assembly, wherein mechanical engagement of the reusable handle assembly and the limited-use needle electrode assembly is permitted, to a second position within the needle assembly, wherein, in the second position, the second electrical contact inhibits mechanical engagement of the reusable handle assembly and the limited-use needle electrode assembly to one another. a reusable handle assembly including a first electrical contact; and a limited-use needle electrode assembly releasably engagable with the reusable handle assembly, the limited-use needle electrode assembly including a second electrical contact within the needle assembly configured to electrically couple to the first electrical contact to establish electrical communication between the reusable handle assembly and the limited-use needle electrode assembly, the second electrical contact movable from a first position, within the needle assembly, wherein mechanical engagement of the reusable handle assembly and the limited-use needle electrode assembly is permitted, to a second position within the needle assembly, wherein, in the second position, the second electrical contact inhibits mechanical engagement of the reusable handle assembly and the limited-use needle electrode assembly to one another.
A roller brush device, comprising: a roller brush; and a mounting assembly connected with the roller brush, the roller brush being rotatable relative to the mounting assembly, the mounting assembly being capable of driving the roller brush to move, a side of the mounting assembly being provided with an avoidance notch, and the roller brush being exposed at the avoidance notch, wherein the mounting assembly comprises a mounting rack and a shielding plate, an interior of the mounting rack is hollow, the shielding plate is sealably arranged in the interior of the mounting rack to separate a space in the mounting rack into a first space and a second space isolated from each other, and the first space is formed into at least a part of the accommodating cavity, characterized in that the roller brush device further comprises a lifting portion connected with the mounting rack, and at least a part of the lifting portion being exposed at a top side of the mounting rack. a roller brush; and a mounting assembly connected with the roller brush, the roller brush being rotatable relative to the mounting assembly, the mounting assembly being capable of driving the roller brush to move, a side of the mounting assembly being provided with an avoidance notch, and the roller brush being exposed at the avoidance notch, wherein the mounting assembly comprises a mounting rack and a shielding plate, an interior of the mounting rack is hollow, the shielding plate is sealably arranged in the interior of the mounting rack to separate a space in the mounting rack into a first space and a second space isolated from each other, and the first space is formed into at least a part of the accommodating cavity, characterized in that the roller brush device further comprises a lifting portion connected with the mounting rack, and at least a part of the lifting portion being exposed at a top side of the mounting rack.
A glycan preparation for use in a method for treating a urea cycle disorder in a human subject, comprising: administering the glycan preparation in an amount effective and for a time sufficient to treat the UCD, wherein: i) the glycan preparation comprises glycan polymers that comprise glucose glycan units; and further wherein ii) the average degree of branching of the glycan polymers in the glycan preparation is between 0.1 and 0.4; iii) at least 50% of the glycan polymers in the glycan preparation have a degree of polymerization of at least 3 and less than 10 glycan units; iv) the average DP (mean DP) of the glycan preparation is between 5 and 8; v) the ratio of alpha- to beta-glycosidic bonds present in the glycan polymers of the glycan preparation is between 1:1 to 3:1; vi) the glycan preparation comprises between 20 mol % and 60 mol % 1,6 glycosidic bonds; vii) the glycan preparation comprises between 5 mol % and 25 mol % of at least one, two, three of 1,2; 1,3; and 1,4 glycosidic bonds; viii) the glycan preparation has a final solubility limit in water of at least 70 Brix at 23 °C; ix) the glycan preparation has a dietary fiber content of at least 70%; or x) any combination of two, three, four, five, six, seven, or eight of ii), iii), iv), v), vi), vii), viii), and ix). i) the glycan preparation comprises glycan polymers that comprise glucose glycan units; ii) the average degree of branching of the glycan polymers in the glycan preparation is between 0.1 and 0.4; iii) at least 50% of the glycan polymers in the glycan preparation have a degree of polymerization of at least 3 and less than 10 glycan units; iv) the average DP (mean DP) of the glycan preparation is between 5 and 8; v) the ratio of alpha- to beta-glycosidic bonds present in the glycan polymers of the glycan preparation is between 1:1 to 3:1; vi) the glycan preparation comprises between 20 mol % and 60 mol % 1,6 glycosidic bonds; vii) the glycan preparation comprises between 5 mol % and 25 mol % of at least one, two, three of 1,2; 1,3; and 1,4 glycosidic bonds; viii) the glycan preparation has a final solubility limit in water of at least 70 Brix at 23 °C; ix) the glycan preparation has a dietary fiber content of at least 70%; or x) any combination of two, three, four, five, six, seven, or eight of ii), iii), iv), v), vi), vii), viii), and ix).
An inhaler containing a unit daily dose of a pharmaceutical formulation comprising 4-{(1 R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1 - hydroxyethyl}-2-(hydroxymethyl)phenol: or a pharmaceutically acceptable salt thereof, a carrier and a ternary agent, wherein the carrier is lactose, the ternary agent is magnesium stearate, and wherein Compound is present in the unit daily dose in an amount of 25 μg, calculated as the free base. or a pharmaceutically acceptable salt thereof, a carrier and a ternary agent, wherein the carrier is lactose, the ternary agent is magnesium stearate, and wherein Compound is present in the unit daily dose in an amount of 25 μg, calculated as the free base.
A linear regulator comprising: a transistor having a control terminal, a first main terminal being a supply terminal connected to a supply input, and a second main terminal being an output terminal configured to provide a regulated output at an output connection; an error amplifier having a reference input, a feedback input and an output connected to the control terminal; a reference current source; a reference circuit configured to provide a reference voltage (Vref) to the reference input from the reference current source; and a feedback circuit from the second main terminal and comprising a feedback resistance (Rfb) provided by one or more resistors and configured to provide a feedback voltage to the feedback input of the error amplifier; characterised in that the feedback circuit and the reference circuit include a common resistance (Rtail, Rd3) provided by one or more resistors, and at least one of the reference circuit and the feedback circuit comprises a capacitive path (Cref) to a ground. a transistor having a control terminal, a first main terminal being a supply terminal connected to a supply input, and a second main terminal being an output terminal configured to provide a regulated output at an output connection; an error amplifier having a reference input, a feedback input and an output connected to the control terminal; a reference current source; a reference circuit configured to provide a reference voltage (Vref) to the reference input from the reference current source; and a feedback circuit from the second main terminal and comprising a feedback resistance (Rfb) provided by one or more resistors and configured to provide a feedback voltage to the feedback input of the error amplifier; characterised in that the feedback circuit and the reference circuit include a common resistance (Rtail, Rd3) provided by one or more resistors, and at least one of the reference circuit and the feedback circuit comprises a capacitive path (Cref) to a ground.
A method of designing an implant for repairing a joint of a patient, comprising: obtaining, in a computer system, two-dimensional or three-dimensional representation of the joint of the patient using electronic image data of the joint of the patient and optionally one or more joints associated with the joint of the patient; obtaining a patient-specific biomotion model using the two-dimensional or three-dimensional representation; designing an implant having a shape based on the two-dimensional or three-dimensional representation; optimizing the shape using the patient-specific biomotion model; and designing an optimized implant having the optimized shape wherein the shape includes at least one of a bone-facing or a joint-facing surface of the implant. obtaining, in a computer system, two-dimensional or three-dimensional representation of the joint of the patient using electronic image data of the joint of the patient and optionally one or more joints associated with the joint of the patient; obtaining a patient-specific biomotion model using the two-dimensional or three-dimensional representation; designing an implant having a shape based on the two-dimensional or three-dimensional representation; optimizing the shape using the patient-specific biomotion model; and designing an optimized implant having the optimized shape wherein the shape includes at least one of a bone-facing or a joint-facing surface of the implant.
Thermochromic seal component produced by a process comprising the steps of: • Preparing a first polymer melt, • Preparing a support layer from the first polymer melt, • Preparing a second polymer melt containing thermochromic pigments, • Preparing a thermochromic surface layer from the second polymer melt and applying the thermochromic surface layer to the carrier layer, wherein • the second polymer melt is heated to a temperature of 150°C to 220°C for melting and is processed to form the surface layer while maintaining this temperature, characterized in that the surface layer is embodied in such a way that it comprises a two-phase, three-phase or multi-phase color change. • Preparing a first polymer melt, • Preparing a support layer from the first polymer melt, • Preparing a second polymer melt containing thermochromic pigments, • Preparing a thermochromic surface layer from the second polymer melt and applying the thermochromic surface layer to the carrier layer, wherein • the second polymer melt is heated to a temperature of 150°C to 220°C for melting and is processed to form the surface layer while maintaining this temperature,
A fastening system for connecting a lifting support associated with a lifting spring to a suspension support, which forms part of a piece of semi-trailer, trailer or similar suspension equipment, characterised in that it comprises an anchoring plate made up of a laminar body that is essentially arched in form, which has an open connecting region with a curvature radius substantially complementary to the diameter of a pivoting bolt located in the suspension support, a nut screw-coupled to one end of said pivoting bolt or any other associated element around said pivoting bolt, said anchoring plate being provided with a pair of through openings in which to insert anchoring screws (12, 12'), capable of passing through at least one through opening present in the lifting support, wherein the lifting support has a region made up of two extensions separated by a curved area in order to partially envelop the pivoting bolt or any other associated element around said pivoting bolt, each one of the extensions having one of the through openings into which the anchoring screws (12, 12') are to be inserted.