A system for ameliorating a symptom of bacterial meningitis in a patient, the system comprising: a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, the catheter being adapted to be introduced in a cerebrospinal fluid space and the ports being spaced axially apart, wherein the catheter assembly includes a catheter shaft having an inner shaft and an outer shaft, the inner shaft defines an infusion lumen, and an aspiration lumen is defined between the inner shaft and the outer shaft; a pump connectable between the first and second lumens to induce a flow of cerebrospinal fluid therebetween; and a filter component (672, 682) connectable between the first and second lumens, the filter component configured to remove i) one or more gram-negative meningitis causing bacterial pathogen selected from a group including Pseudomonas bacteria, Acinetobacter bacteria, Klebsiella bacteria, or combinations thereof and ii) cytokines selected from the group including IL-1ra, IL-6, TNF, CRP, and CXCL10, or combinations thereof from cerebrospinal fluid, to thereby condition the cerebrospinal fluid; and wherein the filter component includes a first filter to separate cerebrospinal fluid into a first clean cerebrospinal pathway and a first waste pathway, a second filter configured to separate the first waste pathway into a second clean cerebrospinal pathway and a second waste pathway, a waste collection apparatus in fluid communication with the second waste pathway, and a return outlet in fluid communication with the first clean cerebrospinal pathway and the second clean cerebrospinal pathway, wherein the first filter, the second filter, or both is a 5kDa filter. a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, the catheter being adapted to be introduced in a cerebrospinal fluid space and the ports being spaced axially apart, wherein the catheter assembly includes a catheter shaft having an inner shaft and an outer shaft, the inner shaft defines an infusion lumen, and an aspiration lumen is defined between the inner shaft and the outer shaft; a pump connectable between the first and second lumens to induce a flow of cerebrospinal fluid therebetween; and a filter component (672, 682) connectable between the first and second lumens, the filter component configured to remove i) one or more gram-negative meningitis causing bacterial pathogen selected from a group including Pseudomonas bacteria, Acinetobacter bacteria, Klebsiella bacteria, or combinations thereof and ii) cytokines selected from the group including IL-1ra, IL-6, TNF, CRP, and CXCL10, or combinations thereof from cerebrospinal fluid, to thereby condition the cerebrospinal fluid; and wherein the filter component includes a first filter to separate cerebrospinal fluid into a first clean cerebrospinal pathway and a first waste pathway, a second filter configured to separate the first waste pathway into a second clean cerebrospinal pathway and a second waste pathway, a waste collection apparatus in fluid communication with the second waste pathway, and a return outlet in fluid communication with the first clean cerebrospinal pathway and the second clean cerebrospinal pathway, wherein the first filter, the second filter, or both is a 5kDa filter.