A nasogastric tube securement system, the system comprising: a base layer (102, 102') configured to be adhered to a nose, the base layer (102, 102') having a first major surface (110, 110') comprising a skin-contact adhesive (112, 112') and a second major surface (114, 114') opposite the first major surface (110, 110'), the base layer (102, 102') having a footprint area of A; and a coupling layer (104, 104', 404, 504, 604) comprising a first end (120, 120', 420, 520, 620) comprising coupling means configured to be repositionably coupled to the second major surface (114, 114') of the base layer (102, 102'), the first end (120, 120') having a footprint area of at least 0.3A, wherein a width of the first end (120, 120', 420, 520, 620) of the coupling layer (104, 104', 505, 604) has a shape suitable for covering a bridge of the nose and at least a part of the lateral sides of the nose, a second end (122, 122', 422, 522, 622) configured to secure a nasogastric tube, and a linear middle section (124, 424, 524, 624) connecting the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622), the middle section (124, 424, 524, 624) elongated along a longitudinal direction, and; wherein the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622) are each wider than the middle section (124, 424, 524, 624) in the lateral direction that is oriented substantially perpendicularly with respect to the longitudinal direction, wherein at least the middle section (124, 424, 524, 624) and the second end (122, 122', 422, 522, 622) of the coupling layer (104, 104', 404, 504, 604) generally form an "L" shape, and wherein the coupling layer (104, 104', 404, 504, 604) is asymmetrical about the longitudinal direction. a base layer (102, 102') configured to be adhered to a nose, the base layer (102, 102') having a first major surface (110, 110') comprising a skin-contact adhesive (112, 112') and a second major surface (114, 114') opposite the first major surface (110, 110'), the base layer (102, 102') having a footprint area of A; and a coupling layer (104, 104', 404, 504, 604) comprising a first end (120, 120', 420, 520, 620) comprising coupling means configured to be repositionably coupled to the second major surface (114, 114') of the base layer (102, 102'), the first end (120, 120') having a footprint area of at least 0.3A, wherein a width of the first end (120, 120', 420, 520, 620) of the coupling layer (104, 104', 505, 604) has a shape suitable for covering a bridge of the nose and at least a part of the lateral sides of the nose, a second end (122, 122', 422, 522, 622) configured to secure a nasogastric tube, and a linear middle section (124, 424, 524, 624) connecting the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622), the middle section (124, 424, 524, 624) elongated along a longitudinal direction, and; wherein the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622) are each wider than the middle section (124, 424, 524, 624) in the lateral direction that is oriented substantially perpendicularly with respect to the longitudinal direction, wherein at least the middle section (124, 424, 524, 624) and the second end (122, 122', 422, 522, 622) of the coupling layer (104, 104', 404, 504, 604) generally form an "L" shape, and wherein the coupling layer (104, 104', 404, 504, 604) is asymmetrical about the longitudinal direction. a first end (120, 120', 420, 520, 620) comprising coupling means configured to be repositionably coupled to the second major surface (114, 114') of the base layer (102, 102'), the first end (120, 120') having a footprint area of at least 0.3A, wherein a width of the first end (120, 120', 420, 520, 620) of the coupling layer (104, 104', 505, 604) has a shape suitable for covering a bridge of the nose and at least a part of the lateral sides of the nose, a second end (122, 122', 422, 522, 622) configured to secure a nasogastric tube, and a linear middle section (124, 424, 524, 624) connecting the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622), the middle section (124, 424, 524, 624) elongated along a longitudinal direction, and; wherein the first end (120, 120', 420, 520, 620) and the second end (122, 122', 422, 522, 622) are each wider than the middle section (124, 424, 524, 624) in the lateral direction that is oriented substantially perpendicularly with respect to the longitudinal direction, wherein at least the middle section (124, 424, 524, 624) and the second end (122, 122', 422, 522, 622) of the coupling layer (104, 104', 404, 504, 604) generally form an "L" shape, and wherein the coupling layer (104, 104', 404, 504, 604) is asymmetrical about the longitudinal direction.