mhurhangee/ep-ind-claims huggingface dataset:
A conjugate having the structure according to Formula XXIIa: wherein P is a polyalkylene glycol polymer; X is O; Z is a straight- or branched-chain, saturated or unsaturated C 1 to C 20 alkyl or heteroalkyl group, C 3 to C 8 saturated or unsaturated cyclic alkyl or cyclic heteroallcyl, a substituted or unsubstituted aryl or heteroaryl group or a substituted or unsubstituted alkaryl wherein the alkyl is a C 1 to C 20 saturated or unsaturated alkyl or heteroalkaryl group, wherein the substituents are selected from the group consisting of halogen, hydroxyl, carbonyl, carboxylate, ester, formyl, acyl, thiocarbonyl, thioester, thioacetate, thioformate, alkoxyl, phosphoryl, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, aromatic moiety, heteroaromatic moiety, imino, silyl, ether, and alkylthiol; R* is a linking moiety formed from the reaction of a moiety selected from the group consisting of aldehyde, aldehyde hydrate, and acetal with a biologically-active compound; B is a biologically-active compound, wherein the biologically-active compound is an interferon-beta; and n is 0 or an integer from 1 to 5. wherein P is a polyalkylene glycol polymer; X is O; Z is a straight- or branched-chain, saturated or unsaturated C 1 to C 20 alkyl or heteroalkyl group, C 3 to C 8 saturated or unsaturated cyclic alkyl or cyclic heteroallcyl, a substituted or unsubstituted aryl or heteroaryl group or a substituted or unsubstituted alkaryl wherein the alkyl is a C 1 to C 20 saturated or unsaturated alkyl or heteroalkaryl group, wherein the substituents are selected from the group consisting of halogen, hydroxyl, carbonyl, carboxylate, ester, formyl, acyl, thiocarbonyl, thioester, thioacetate, thioformate, alkoxyl, phosphoryl, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, aromatic moiety, heteroaromatic moiety, imino, silyl, ether, and alkylthiol; R* is a linking moiety formed from the reaction of a moiety selected from the group consisting of aldehyde, aldehyde hydrate, and acetal with a biologically-active compound; B is a biologically-active compound, wherein the biologically-active compound is an interferon-beta; and n is 0 or an integer from 1 to 5.
A method of manufacturing a hyaluronate-coated polydioxanone suture, comprising the steps of: (a) dissolving a hyaluronate in purified water (b) adding an organic solvent to the hyaluronate aqueous solution, wherein the organic solvent is ethanol, to thereby prepare a hyaluronate ethanol aqueous solution having an ethanol concentration of 50 ∼ 70 vol% and a hyaluronate concentration of 0.5 ∼ 2 vol%; and (c) coating a polydioxanone suture with the hyaluronate ethanol aqueous solution and then drying the suture, wherein the hyaluronate of the hyaluronate ethanol aqueous solution has a weight average molecular weight of 5 ∼ 100 kDa. (a) dissolving a hyaluronate in purified water (b) adding an organic solvent to the hyaluronate aqueous solution, wherein the organic solvent is ethanol, to thereby prepare a hyaluronate ethanol aqueous solution having an ethanol concentration of 50 ∼ 70 vol% and a hyaluronate concentration of 0.5 ∼ 2 vol%; and (c) coating a polydioxanone suture with the hyaluronate ethanol aqueous solution and then drying the suture,
Toothbrush having a bristle carrier produced using the injection-moulding method from a hard material and having injection-moulded bristles (16, 18), which are carried by the bristle carrier, are produced using the injection-moulding method from a bristle material (62, 62') and have a bristle stem, where a surface layer produced from the bristle material (62, 62') and realized on the front side of the bristle carrier is injected on the bristle carrier, and at least a large number of the injection-moulded bristles (16, 18) are realized integrally with the surface layer and protrude from the said surface layer, there being positive locking between the bristle material and the hard material of the bristle carrier, characterized in that at least one bristle-free, flexible massaging and cleaning element consisting of a soft material is injected on the bristle carrier, and in that the bristle material (62, 62') has a hardness of from 10 to 100 Shore D, where the Shore hardness of the soft material for the at least one bristle-free, flexible massaging and cleaning element is lower than the Shore hardness of the bristle material (62, 62') for the injection-moulded bristles (16, 18).
An RFID transponder comprising: - an antenna device; - a rectifier; - a microcontroller which has a processor and a storage device that is configured to store data received via the antenna device and is connected to the rectifier via a voltage control device to receive a microcontroller operating voltage; and - at least one additional functional component (3.1, 3.2, 3.3) that is connected to the microcontroller and the operation of which is controlled by means of the microcontroller; characterized by a Zener diode which is connected between an input side of the voltage control device and a supply terminal of the at least one additional functional component (3.1, 3.2, 3.3), in such a manner that the Zener diode is connected with one side between the voltage control device and the rectifier and is connected, in the reverse direction, in series to the at least one additional functional component (3.1, 3.2, 3.3). - an antenna device; - a rectifier; - a microcontroller which has a processor and a storage device that is configured to store data received via the antenna device and is connected to the rectifier via a voltage control device to receive a microcontroller operating voltage; and - at least one additional functional component (3.1, 3.2, 3.3) that is connected to the microcontroller and the operation of which is controlled by means of the microcontroller;
A latent heat exchange chamber having an arrangement and condensing on its outer face and evaporating on its inner face; characterized in that an outer face of the chamber is covered, at least in part, with microgrooves or other capillary structure, wherein the microgrooves or other capillary structure are configured to allow vapour to condense in a capillary regime forming condensing menisci with a concave liquid-vapour interface inside the microgrooves or other capillary structure; wherein an inner face of the chamber is covered, at least in part, with microgrooves or micro undulations, the microgrooves or micro undulations being configured to allow a liquid to be evaporated to flow through them forming evaporating menisci with a concave liquid-vapour interface inside the microgrooves or micro undulations such that the evaporation occurs from the upper end of the menisci where the evaporation is most efficient; the arrangement comprising a liquid supplying system configured to supply the liquid to be evaporated without obstructions, in a direct and controlled manner, on the inner face of the chamber without undesired liquid overflows in the microgrooves or micro undulations in such a way that dry areas are reduced or eliminated; and wherein one section of the chamber wall of the chamber has a zigzag, crenellated or corrugated shape in the direction of the microgrooves or micro undulations, the chamber wall being configured to have a thermal path free of liquid layers between an upper part of the condensing menisci where the vapour condenses and the latent heat of condensation is released and the upper ends of the evaporating menisci where the liquid evaporates and the latent heat of evaporation is absorbed. the arrangement comprising a liquid supplying system configured to supply the liquid to be evaporated without obstructions, in a direct and controlled manner, on the inner face of the chamber without undesired liquid overflows in the microgrooves or micro undulations in such a way that dry areas are reduced or eliminated; and wherein one section of the chamber wall of the chamber has a zigzag, crenellated or corrugated shape in the direction of the microgrooves or micro undulations, the chamber wall being configured to have a thermal path free of liquid layers between an upper part of the condensing menisci where the vapour condenses and the latent heat of condensation is released and the upper ends of the evaporating menisci where the liquid evaporates and the latent heat of evaporation is absorbed.
An optical display device, comprising: at least one region comprising a plurality of nanostructures operable together as an optically active media, such that said plurality of nanostructures are responsive to input electromagnetic radiation to emit output electromagnetic radiation of predetermined wavelength range; and an arrangement of electrodes being configured and operable to be selectively addressable to apply an external electric field to said at least one region of nanostructures, said at least one region of nanostructures and said arrangement of electrodes defining together at least one pixel of said display device; and said external electric field affecting said at least one region of nanostructures to selectively quench emission of said output electromagnetic radiation of the predetermined wavelength range while said plurality of nanostructures are being subjected to the exciting electromagnetic radiation, the quenched emission of said electromagnetic radiation being an output of said at least one pixel element of the display device; said at least one region comprising a plurality of nanostructures thereby carrying out selective emission of said predetermined wavelength generated by input exciting electromagnetic radiation and providing selective spatial modulation of said emission of said predetermined wavelength range in response to the application of the electric field, in accordance with an image to be displayed, characterized in that said at least one region comprising a plurality of nanostructures is manufactured such that the region does not contain any solvent. at least one region comprising a plurality of nanostructures operable together as an optically active media, such that said plurality of nanostructures are responsive to input electromagnetic radiation to emit output electromagnetic radiation of predetermined wavelength range; and an arrangement of electrodes being configured and operable to be selectively addressable to apply an external electric field to said at least one region of nanostructures, said at least one region of nanostructures and said arrangement of electrodes defining together at least one pixel of said display device; and said external electric field affecting said at least one region of nanostructures to selectively quench emission of said output electromagnetic radiation of the predetermined wavelength range while said plurality of nanostructures are being subjected to the exciting electromagnetic radiation, the quenched emission of said electromagnetic radiation being an output of said at least one pixel element of the display device; said at least one region comprising a plurality of nanostructures thereby carrying out selective emission of said predetermined wavelength generated by input exciting electromagnetic radiation and providing selective spatial modulation of said emission of said predetermined wavelength range in response to the application of the electric field, in accordance with an image to be displayed, characterized in that said at least one region comprising a plurality of nanostructures is manufactured such that the region does not contain any solvent.
A sensor device comprising: an array sensor having a plurality of detection elements arrayed in one or two dimensional manner; a signal processing unit configured to acquire a detection signal by the array sensor and to perform signal processing on the detection signal; and a calculation unit configured to detect an object from the detection signal, and to give an instruction, to the signal processing unit, on region information wherein the region information is generated on a basis of the detection of the object, and is generated as region information regarding the acquisition region of the detection signal from the array sensor, and the calculation unit is configured to identify a class for the object detected from the detection signal, to obtain a bounding box surrounding a region of the object detected from the detection signal by the array sensor, and to generate the region information corresponding to the object, by adjusting the size of a template according to the size of the bounding box, which template indicates said acquisition region of the detection signal corresponding to the identified class. an array sensor having a plurality of detection elements arrayed in one or two dimensional manner; a signal processing unit configured to acquire a detection signal by the array sensor and to perform signal processing on the detection signal; and a calculation unit configured to detect an object from the detection signal, and to give an instruction, to the signal processing unit, on region information wherein the region information is generated on a basis of the detection of the object, and is generated as region information regarding the acquisition region of the detection signal from the array sensor, and the calculation unit is configured to identify a class for the object detected from the detection signal, to obtain a bounding box surrounding a region of the object detected from the detection signal by the array sensor, and to generate the region information corresponding to the object, by adjusting the size of a template according to the size of the bounding box, which template indicates said acquisition region of the detection signal corresponding to the identified class.
A polynucleotide according to any one selected from the group consisting of (a) to (e) below: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 4; (b) a polynucleotide encoding a protein consisting of the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide encoding a protein consisting of an amino acid sequence wherein 1 to 100 amino acids are deleted, substituted, inserted and/or added in the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; (d) a polynucleotide encoding a protein having an amino acid sequence having at least 60% homology to the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; and, (e) a polynucleotide which hybridizes under stringent conditions to a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO: 1 or 4, wherein said nucleotide sequence encodes a protein having diacylglycerol acyltransferase activity. (a) to (e) below: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 4; (b) a polynucleotide encoding a protein consisting of the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide encoding a protein consisting of an amino acid sequence wherein 1 to 100 amino acids are deleted, substituted, inserted and/or added in the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; (d) a polynucleotide encoding a protein having an amino acid sequence having at least 60% homology to the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; and, (e) a polynucleotide which hybridizes under stringent conditions to a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO: 1 or 4, wherein said nucleotide sequence encodes a protein having diacylglycerol acyltransferase activity. (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 4; (b) a polynucleotide encoding a protein consisting of the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide encoding a protein consisting of an amino acid sequence wherein 1 to 100 amino acids are deleted, substituted, inserted and/or added in the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; (d) a polynucleotide encoding a protein having an amino acid sequence having at least 60% homology to the amino acid sequence of SEQ ID NO: 2, wherein said protein has diacylglycerol acyltransferase activity; and, (e) a polynucleotide which hybridizes under stringent conditions to a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO: 1 or 4, wherein said nucleotide sequence encodes a protein having diacylglycerol acyltransferase activity.
A method of removing a wellbore isolation device comprising: contacting or allowing the wellbore isolation device to come in contact with a wellbore fluid, wherein at least a portion of the wellbore isolation device comprises a material that dissolves via corrosion when in contact with the wellbore fluid, wherein the surface of the portion of the isolation device is altered via a surface treatment, and wherein the altered surface delays corrosion of at least a portion of the material for a desired amount of time, wherein the altered surface contains pores and a sealant, wherein the sealant is a degradable substance and is placed over the altered surface and fills the pores; and causing or allowing at least the portion of the material to dissolve. contacting or allowing the wellbore isolation device to come in contact with a wellbore fluid, wherein at least a portion of the wellbore isolation device comprises a material that dissolves via corrosion when in contact with the wellbore fluid, wherein the surface of the portion of the isolation device is altered via a surface treatment, and wherein the altered surface delays corrosion of at least a portion of the material for a desired amount of time, wherein the altered surface contains pores and a sealant, wherein the sealant is a degradable substance and is placed over the altered surface and fills the pores; and causing or allowing at least the portion of the material to dissolve.
A method for controlling bit rate and power states of components of a network, the network comprising a mobile radio network, an access network, a home network and aggregation network, wherein the mobile radio network is connected to the aggregation network and the home network is connected to the aggregation network via the access network, comprising the steps of: - continuously acquiring the position data of a mobile radio terminal and its data rate demand by components of the mobile radio network; - forwarding the position data and the data rate demand from the mobile radio network to components in the aggregation network which are in local proximity with respect to the position data and which are thus responsible for satisfying the data rate demand of the mobile radio terminal; - Independent control of the bit rate and power states of the components in the aggregation network on the basis of the transmitted position data and the data rate requirement, thereby reducing power and energy consumption, wherein components of the access network perform a control of the bit rate and power states of the components in the access network as a function of the position data and an associated identifier of the mobile radio terminal which are transmitted to the components of the access network, wherein if it is detected that a mobile radio terminal which is assigned to a home network is approaching the latter, the bit rate of the components is increased in the access network and/or home network and if the mobile radio terminal is removed, the bit rate can be reduced. - continuously acquiring the position data of a mobile radio terminal and its data rate demand by components of the mobile radio network; - forwarding the position data and the data rate demand from the mobile radio network to components in the aggregation network which are in local proximity with respect to the position data and which are thus responsible for satisfying the data rate demand of the mobile radio terminal; - Independent control of the bit rate and power states of the components in the aggregation network on the basis of the transmitted position data and the data rate requirement, thereby reducing power and energy consumption,
Use of an inhibitor of the bromodomain-containing protein SP140 in the manufacture of a medicament for the treatment of autoimmune and inflammatory diseases or conditions or cancer wherein the inhibitor is selected from an siRNA, ribozyme or an antisense oligonucleotide complementary to the SP140 mRNA, or an antibody binding to the SP140 protein.
An analytics system configured to communicably couple to a surgical hub, the surgical hub configured to communicably couple to a modular device that is controlled by a control program, the analytics system comprising: a processor; and a memory coupled to the processor, the memory storing instructions that, when executed by the processor, cause the analytics system to: receive perioperative data indicative of a first and second operational behavior of the modular device, wherein the perioperative data comprises data detected by the modular device during a surgical procedure; receive procedural outcome data associated with the surgical procedure; analyze the perioperative data and the procedural outcome data to determine whether the first operational behavior is suboptimal according to whether the second operational behavior is more highly correlated to a positive procedural outcome than the first operational behavior; generate a control program update configured to alter the manner in which the control program operates the modular device during the surgical procedure for the first operational behavior; and transmit the control program update to the modular device. a processor; and a memory coupled to the processor, the memory storing instructions that, when executed by the processor, cause the analytics system to: receive perioperative data indicative of a first and second operational behavior of the modular device, wherein the perioperative data comprises data detected by the modular device during a surgical procedure; receive procedural outcome data associated with the surgical procedure; analyze the perioperative data and the procedural outcome data to determine whether the first operational behavior is suboptimal according to whether the second operational behavior is more highly correlated to a positive procedural outcome than the first operational behavior; generate a control program update configured to alter the manner in which the control program operates the modular device during the surgical procedure for the first operational behavior; and transmit the control program update to the modular device. receive perioperative data indicative of a first and second operational behavior of the modular device, wherein the perioperative data comprises data detected by the modular device during a surgical procedure; receive procedural outcome data associated with the surgical procedure; analyze the perioperative data and the procedural outcome data to determine whether the first operational behavior is suboptimal according to whether the second operational behavior is more highly correlated to a positive procedural outcome than the first operational behavior; generate a control program update configured to alter the manner in which the control program operates the modular device during the surgical procedure for the first operational behavior; and transmit the control program update to the modular device.