An endoscopic resection apparatus comprising: an elongated body comprising a proximal end and a distal end; a resection frame located proximate the distal end of the elongated body, the resection frame comprising two spaced apart rails (42a, 42b) and a cross-member connecting the two rails at a location spaced from the distal end of the elongated body, wherein the resection frame comprises an extended position and a retracted position; a cutting instrument located on the cross-member between the two spaced apart rails (42a, 42b) of the resection frame, wherein the cutting instrument is displaced from the distal end of the elongated body when the resection frame is in the extended position, and wherein movement of the resection frame to the retracted position moves the cross-member and the cutting instrument towards the distal end of the elongated body; a resection opening defined by the two spaced apart rails (42a, 42b), the cross-member, and the distal end when the resection frame is in the extended position, wherein the size of the resection opening decreases and wherein tissue extending through the resection opening is severed by the cutting instrument when the resection frame is moved into the retracted position from the extended position; said endoscopic resection apparatus being characterized in that it further comprises a plurality of staples, retained proximate to the distal end of the elongate body, and a stapling anvil, located on the cross-member, and wherein the plurality of staples and the stapling anvil are located on opposite sides of the resection opening when the resection frame is in the extended position, and further wherein movement of the resection frame into the retracted position forces the plurality of staples into contact with the stapling anvil, wherein the staples and the stapling anvil cooperate to staple tissue extending through the resection opening when the resection frame is moved into the retracted position from the extended position. an elongated body comprising a proximal end and a distal end; a resection frame located proximate the distal end of the elongated body, the resection frame comprising two spaced apart rails (42a, 42b) and a cross-member connecting the two rails at a location spaced from the distal end of the elongated body, wherein the resection frame comprises an extended position and a retracted position; a cutting instrument located on the cross-member between the two spaced apart rails (42a, 42b) of the resection frame, wherein the cutting instrument is displaced from the distal end of the elongated body when the resection frame is in the extended position, and wherein movement of the resection frame to the retracted position moves the cross-member and the cutting instrument towards the distal end of the elongated body; a resection opening defined by the two spaced apart rails (42a, 42b), the cross-member, and the distal end when the resection frame is in the extended position, wherein the size of the resection opening decreases and wherein tissue extending through the resection opening is severed by the cutting instrument when the resection frame is moved into the retracted position from the extended position; said endoscopic resection apparatus being characterized in that it further comprises a plurality of staples, retained proximate to the distal end of the elongate body, and a stapling anvil, located on the cross-member, and wherein the plurality of staples and the stapling anvil are located on opposite sides of the resection opening when the resection frame is in the extended position, and further wherein movement of the resection frame into the retracted position forces the plurality of staples into contact with the stapling anvil, wherein the staples and the stapling anvil cooperate to staple tissue extending through the resection opening when the resection frame is moved into the retracted position from the extended position.