A single-use, disposable, hand-held medical liquid applicator system, the applicator system comprising: a rigid, flat, planar applicator grip assembly comprising a first section having a first distal end and a second section having a second distal end, a longitudinal axis, a front side, a back side, a predetermined grip length, a predetermined grip width, a fold axis separating the first section and the second section, the fold axis being perpendicular to the longitudinal axis, and a fold-activated dispensing slit; a flexible reservoir, the reservoir comprising a flexible pouch and containing at least 1 milliliter of a flowable medical liquid, and the flexible reservoir in liquid communication with the fold-activated dispensing slit; an applicator head joined to the front side of the applicator grip assembly at the fold axis and in liquid communication with the dispensing slit, the applicator head comprising a porous material adapted to receive the flowable medical liquid and to release the flowable medical liquid to a substrate; wherein the applicator grip assembly is adapted to fold at the fold axis to bring the back side of at least a portion of the first distal end of the first section and the back side of at least a portion of the second distal end of the second section together to define a grip handle having the predetermined grip length and the predetermined grip width and further to rupture the fold-activated dispensing slit thereby defining a dispensing opening and apply pressure to the flexible reservoir in liquid communication with the dispensing slit thereby urging flowable medical liquid through the dispensing opening and into the applicator head; characterised in that: the flexible reservoir joined to a back side of the applicator grip assembly; the fold-activated dispensing slit is located on the fold axis; and in further comprising a spacer section intermediate the first section and the second section of the applicator grip assembly; wherein there are two fold axes Including a first fold axis between the first section and the spacer section and a second fold axis between the second section and the spacer section, each fold axis (55,55') being perpendicular to the longitudinal axis, the spacer section having a length much shorter than the first section and the second section; and wherein there is at least one fold-activated dispensing slit located on at least one fold axis (55,55'); and wherein the applicator grip assembly is adapted to fold at each fold axis (55,55') to define the grip handle and further to rupture the at least one fold-activated dispensing slit thereby defining at least one dispensing opening and apply pressure to the flexible reservoir element in liquid communication with the dispensing slit thereby urging flowable medical liquid through the dispensing opening and into the applicator head. a rigid, flat, planar applicator grip assembly comprising a first section having a first distal end and a second section having a second distal end, a longitudinal axis, a front side, a back side, a predetermined grip length, a predetermined grip width, a fold axis separating the first section and the second section, the fold axis being perpendicular to the longitudinal axis, and a fold-activated dispensing slit; a flexible reservoir, the reservoir comprising a flexible pouch and containing at least 1 milliliter of a flowable medical liquid, and the flexible reservoir in liquid communication with the fold-activated dispensing slit; an applicator head joined to the front side of the applicator grip assembly at the fold axis and in liquid communication with the dispensing slit, the applicator head comprising a porous material adapted to receive the flowable medical liquid and to release the flowable medical liquid to a substrate; wherein the applicator grip assembly is adapted to fold at the fold axis to bring the back side of at least a portion of the first distal end of the first section and the back side of at least a portion of the second distal end of the second section together to define a grip handle having the predetermined grip length and the predetermined grip width and further to rupture the fold-activated dispensing slit thereby defining a dispensing opening and apply pressure to the flexible reservoir in liquid communication with the dispensing slit thereby urging flowable medical liquid through the dispensing opening and into the applicator head; the flexible reservoir joined to a back side of the applicator grip assembly; the fold-activated dispensing slit is located on the fold axis; and in further comprising a spacer section intermediate the first section and the second section of the applicator grip assembly; wherein there are two fold axes Including a first fold axis between the first section and the spacer section and a second fold axis between the second section and the spacer section, each fold axis (55,55') being perpendicular to the longitudinal axis, the spacer section having a length much shorter than the first section and the second section; and wherein there is at least one fold-activated dispensing slit located on at least one fold axis (55,55'); and wherein the applicator grip assembly is adapted to fold at each fold axis (55,55') to define the grip handle and further to rupture the at least one fold-activated dispensing slit thereby defining at least one dispensing opening and apply pressure to the flexible reservoir element in liquid communication with the dispensing slit thereby urging flowable medical liquid through the dispensing opening and into the applicator head.