mhurhangee/ep-ind-claims huggingface dataset:
Bendamustine free base-containing particles obtainable by a process comprising: forming an emulsion by mixing a continuous phase comprising an organic solvent, a dispersed phase comprising an aqueous solution of a pharmaceutically acceptable salt of bendamustine, and at least one polyhydric alcohol surfactant; treating the emulsion with an amount of base sufficient to convert the pharmaceutically acceptable salt of bendamustine to bendamustine free base; treating the emulsion with a compound comprising at least two isocyanate moieties; allowing sufficient time for the isocyanate-containing compound to polymerize with the at least one polyhydric alcohol surfactant at the water-polyhydric alcohol interface to form the bendamustine-containing particles; and isolating the particles. forming an emulsion by mixing a continuous phase comprising an organic solvent, a dispersed phase comprising an aqueous solution of a pharmaceutically acceptable salt of bendamustine, and at least one polyhydric alcohol surfactant; treating the emulsion with an amount of base sufficient to convert the pharmaceutically acceptable salt of bendamustine to bendamustine free base; treating the emulsion with a compound comprising at least two isocyanate moieties; allowing sufficient time for the isocyanate-containing compound to polymerize with the at least one polyhydric alcohol surfactant at the water-polyhydric alcohol interface to form the bendamustine-containing particles; and isolating the particles.
A method of stabilizing an isolated heteromultimer at about pH 5.0 wherein the heteromultimer comprises a heterodimeric CH3 domain comprising a first CH3 domain polypeptide and a second CH3 domain polypeptide, wherein: (i) the first CH3 domain polypeptide comprises an amino acid modification at position K370, and (ii) the second CH3 domain polypeptide comprises an amino acid modification at position E357, the method comprising introducing an amino acid modification at position K360 of the first CH3 domain; wherein the amino acid modification at position K360 is K360E, the amino acid modification at position K370 is K370D, and the amino acid modification at position E357 is E357K; wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat. (i) the first CH3 domain polypeptide comprises an amino acid modification at position K370, and (ii) the second CH3 domain polypeptide comprises an amino acid modification at position E357, the method comprising introducing an amino acid modification at position K360 of the first CH3 domain; wherein the amino acid modification at position K360 is K360E, the amino acid modification at position K370 is K370D, and the amino acid modification at position E357 is E357K; wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat. the method comprising introducing an amino acid modification at position K360 of the first CH3 domain; wherein the amino acid modification at position K360 is K360E, the amino acid modification at position K370 is K370D, and the amino acid modification at position E357 is E357K; wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat.
A co-extrusion device, comprising: at least one first inlet port to receive a first material; at least one second inlet port to receive a second material; a first combining channel arranged to receive the first material and the second material and combine the first and second materials into a first combined flow flowing in a first direction; a splitter channel (48,50) arranged to receive the first combined flow and to split the first combined flow into at least two split flows (20,22) in a second direction, wherein each split flow consists of the first and second materials; a second combining channel arranged to receive the split flows and combine the split flows into a second combined flow in the first direction; and at least one exit orifice arranged to allow the materials to exit the device as a single flow, wherein the combining channels each further comprise a focusing region (46,52) arranged to focus the combined flows into a combined flow (18,26) that has a lateral extent less than the lateral extent of the sum of the lateral extents of the individual flows previous to the flows being combined, characterised in that the second direction is at least partially orthogonal to the first direction. at least one first inlet port to receive a first material; at least one second inlet port to receive a second material; a first combining channel arranged to receive the first material and the second material and combine the first and second materials into a first combined flow flowing in a first direction; a splitter channel (48,50) arranged to receive the first combined flow and to split the first combined flow into at least two split flows (20,22) in a second direction, wherein each split flow consists of the first and second materials; a second combining channel arranged to receive the split flows and combine the split flows into a second combined flow in the first direction; and at least one exit orifice arranged to allow the materials to exit the device as a single flow, wherein the combining channels each further comprise a focusing region (46,52) arranged to focus the combined flows into a combined flow (18,26) that has a lateral extent less than the lateral extent of the sum of the lateral extents of the individual flows previous to the flows being combined, characterised in that the second direction is at least partially orthogonal to the first direction.
A method for serialization of items, comprising: encrypting a unique serial number of each item using encryption key k to obtain a corresponding unique code, and marking each item with its corresponding unique code, characterized in that each unique code has a length L and is included into a string of symbols having a length L' that is marked on the corresponding item, wherein L' is larger than L, and wherein the string of symbols further includes at least a part of a unique code obtained from encrypting a preceding unique serial number and/or at least a part of a unique code obtained from encrypting a next unique serial number, wherein in the string of symbols the unique code corresponding to the item is concatenated ahead with the end of the unique code obtained from encrypting the preceding unique serial number and/or concatenated after with the beginning of the unique code obtained from encrypting the next unique serial number. encrypting a unique serial number of each item using encryption key k to obtain a corresponding unique code, and marking each item with its corresponding unique code, characterized in that each unique code has a length L and is included into a string of symbols having a length L' that is marked on the corresponding item, wherein L' is larger than L, and wherein the string of symbols further includes at least a part of a unique code obtained from encrypting a preceding unique serial number and/or at least a part of a unique code obtained from encrypting a next unique serial number, wherein in the string of symbols the unique code corresponding to the item is concatenated ahead with the end of the unique code obtained from encrypting the preceding unique serial number and/or concatenated after with the beginning of the unique code obtained from encrypting the next unique serial number.
A draper belt comprising a carcass, a plurality of cleats extending from the carcass, and a plurality of v-guides disposed perpendicular to the plurality of cleats; characterized in that, the draper belt further comprises at least one sensor (2, 5, 6, 8) for measuring and relaying information regarding key measureable properties about the draper belt; and wherein the at least one sensor (2, 5, 6, 8) is configured to measure a belt speed, a belt temperature, a belt stress or a belt alignment, wherein the at least one sensor (2, 5, 6, 8) is configured to communicate with a belt protection controller, wherein the at least one sensor (2, 5, 6, 8) is an embedded radio frequency identification tag disposed within the carcass, and wherein either a transverse antenna associated with the radio frequency identification tag is disposed within a cleat located proximate the embedded radio frequency identification tag or a longitudinal antenna associated with the radio frequency identification tag is disposed within at least one of the plurality of V-guides. characterized in that, the draper belt further comprises at least one sensor (2, 5, 6, 8) for measuring and relaying information regarding key measureable properties about the draper belt; and wherein the at least one sensor (2, 5, 6, 8) is configured to measure a belt speed, a belt temperature, a belt stress or a belt alignment, wherein the at least one sensor (2, 5, 6, 8) is configured to communicate with a belt protection controller, wherein the at least one sensor (2, 5, 6, 8) is an embedded radio frequency identification tag disposed within the carcass, and wherein either a transverse antenna associated with the radio frequency identification tag is disposed within a cleat located proximate the embedded radio frequency identification tag or a longitudinal antenna associated with the radio frequency identification tag is disposed within at least one of the plurality of V-guides.
A disposable absorbent article that includes a chassis having a front region with a front edge, a rear region with a back edge, a crotch region between the front region and the rear region, and a pair of opposing longitudinal edges, said chassis comprising an absorbent core having front and back edges (428, 528) wherein said absorbent core is substantially cellulose free, wherein at least a portion of the absorbent core contains less than 10% by weight cellulosic fibers, said disposable absorbent article comprises: a) first and second elastically elongatable ears (42, 42'), each of said first and second ears (42, 42') having upper and lower edges (142, 242) and a transverse axis (Te), each of said upper and lower edges (142, 242) having proximal and distal ends (1142, 1242), said first and second ears (42, 42') defining a back section of said absorbent article that is present between said back edge of said chassis and a line (A-A) connecting the respective lower ends of the lower edge (1242, 1242') of said first and second ears(42, 42'); and b) first and second fastening tabs (52, 52') respectively connected to a distal portion of said first and second elastically elongatable ears (42, 42'), each of said first and second fastening tabs (52, 52') having upper and lower edges (152, 252) and a transverse axis (Tf), wherein said upper and lower edges (152, 252) of said fastening tabs are asymmetric relative to the transverse axis (Tf) of the fastening tabs (52, 52'), characterized in that the back section of said absorbent article comprises less than about 5 grams of a particulate absorbent polymer material; wherein the back section comprises an absorbent core that is substantially cellulose free; wherein the transverse axis (Tf) of the fastening tabs (52, 52') and the back edge of the absorbent core are separated by a longitudinal distance between 2 mm and 20 mm; and wherein the back edge of the chassis and the back edge of the absorbent core are separated by a longitudinal distance of less than 100 mm. a) first and second elastically elongatable ears (42, 42'), each of said first and second ears (42, 42') having upper and lower edges (142, 242) and a transverse axis (Te), each of said upper and lower edges (142, 242) having proximal and distal ends (1142, 1242), said first and second ears (42, 42') defining a back section of said absorbent article that is present between said back edge of said chassis and a line (A-A) connecting the respective lower ends of the lower edge (1242, 1242') of said first and second ears(42, 42'); and b) first and second fastening tabs (52, 52') respectively connected to a distal portion of said first and second elastically elongatable ears (42, 42'), each of said first and second fastening tabs (52, 52') having upper and lower edges (152, 252) and a transverse axis (Tf), wherein said upper and lower edges (152, 252) of said fastening tabs are asymmetric relative to the transverse axis (Tf) of the fastening tabs (52, 52'),
A communication connection apparatus that is configured to control connection of a communication line between at least one first communication devices and at least one second communication devices, the communication connection apparatus comprising: a first connection port to which a connection line to the at least one first communication devices is connected, and which includes a first transmission unit through which a signal output from the at least one first communication devices passes and a first reception unit through which a signal to be input to the at least one first communication devices passes; a second connection port to which a connection line to the at least one second communication devices is connected, and which includes a second transmission unit through which a signal output from the at least one second communication devices passes and a second reception unit through which a signal to be input to the at least one second communication devices passes; a first connection line that connects the first transmission unit and the second reception unit to each other; a simulated-signal input unit that inputs, to the first reception unit, a first signal which is a signal for recognizing that the at least one first communication devices is connectable to other devices; and a switching unit that includes a physical switch which is operated by a user to switch between a first communication mode and a second communication mode, wherein when the first signal is being input to the first reception unit, the first reception unit and the second transmission unit are physically disconnected from each other. a first connection port to which a connection line to the at least one first communication devices is connected, and which includes a first transmission unit through which a signal output from the at least one first communication devices passes and a first reception unit through which a signal to be input to the at least one first communication devices passes; a second connection port to which a connection line to the at least one second communication devices is connected, and which includes a second transmission unit through which a signal output from the at least one second communication devices passes and a second reception unit through which a signal to be input to the at least one second communication devices passes; a first connection line that connects the first transmission unit and the second reception unit to each other; a simulated-signal input unit that inputs, to the first reception unit, a first signal which is a signal for recognizing that the at least one first communication devices is connectable to other devices; and a switching unit that includes a physical switch which is operated by a user to switch between a first communication mode and a second communication mode, wherein when the first signal is being input to the first reception unit, the first reception unit and the second transmission unit are physically disconnected from each other.
A method comprising: receiving, by a wireless device from a base station, one or more radio resource control messages comprising configuration parameters of a cell, wherein the configuration parameters comprise: a first preamble received target power value for beam failure recovery associated with the cell; and a second preamble received target power value for random access associated with the cell; based on detecting a beam failure of the cell, transmitting, using a first transmission power that is based on the first preamble received target power value, a first preamble for beam failure recovery associated with the beam failure of the cell; and transmitting, via the cell and using a second transmission power that is based on the second preamble received target power value, a second preamble associated with random access. receiving, by a wireless device from a base station, one or more radio resource control messages comprising configuration parameters of a cell, wherein the configuration parameters comprise: a first preamble received target power value for beam failure recovery associated with the cell; and a second preamble received target power value for random access associated with the cell; a first preamble received target power value for beam failure recovery associated with the cell; and a second preamble received target power value for random access associated with the cell; based on detecting a beam failure of the cell, transmitting, using a first transmission power that is based on the first preamble received target power value, a first preamble for beam failure recovery associated with the beam failure of the cell; and transmitting, via the cell and using a second transmission power that is based on the second preamble received target power value, a second preamble associated with random access.
Use of a cosmetic composition comprising, in a cosmetically acceptable medium, at least one hair conditioning agent selected from the group of cationic polymers, cationic surfactants, quaternary ammonium compounds present in nonpolymeric form, organopolysiloxanes and organopolysiloxane copolymers different from the precrosslinked organopolysiloxanes of the formula, fatty acid esters and fatty acid alcohols, natural or synthetic oils and waxes and panthenol, lipids, proteins and hydrolyzed proteins, and mixtures thereof and at least one aqueous dispersion of precrosslinked organopolysiloxanes of units of the general formula A K T n R 2 b R c ( O R 1) d S i O 4 − n + b + c + d 2 where R may be identical or different and is a monovalent, saturated or unsaturated hydrocarbon radical having 1 to 200 carbon atoms per radical, which can contain one or more heteroatoms from the group N, P, S, O, and halogen, R 1 may be identical or different and is a hydrogen atom or an alkyl radical having 1 to 8 carbon atoms per radical, R 2 may be identical or different and is a monovalent, optionally substituted hydrocarbon radical having 1 to 18 carbon atoms per radical, AKT is a radical of the formula -CH 2 NHR 4, -CH 2 NR 4 2 or -CH 2 RN 5, where R 4 is a monovalent hydrocarbon radical having 1 to 18 carbon atoms, which can contain one or more heteroatoms from the group N and O, and R 5 is a divalent hydrocarbon radical having 3 to 12 carbon atoms, which can contain one or more heteroatoms from the group N and O, b is 0, 1 or 2, c is 0, 1, 2 or 3, d is 0, 1 or 2, and n is 0, 1 or 2, with the proviso that the sum n+b+c+d is ≤ 3 and that on average at least one radical AKT is present per molecule, for treating keratin fibers, preferably hair. R may be identical or different and is a monovalent, saturated or unsaturated hydrocarbon radical having 1 to 200 carbon atoms per radical, which can contain one or more heteroatoms from the group N, P, S, O, and halogen, R 1 may be identical or different and is a hydrogen atom or an alkyl radical having 1 to 8 carbon atoms per radical, R 2 may be identical or different and is a monovalent, optionally substituted hydrocarbon radical having 1 to 18 carbon atoms per radical, AKT is a radical of the formula -CH 2 NHR 4, -CH 2 NR 4 2 or -CH 2 RN 5, where R 4 is a monovalent hydrocarbon radical having 1 to 18 carbon atoms, which can contain one or more heteroatoms from the group N and O, and R 5 is a divalent hydrocarbon radical having 3 to 12 carbon atoms, which can contain one or more heteroatoms from the group N and O, b is 0, 1 or 2, c is 0, 1, 2 or 3, d is 0, 1 or 2, and n is 0, 1 or 2,
A toner for developing an electrostatic charge image, comprising: a toner particle and an external additive, the toner particle comprising: a binder resin containing a crystalline polyester resin, a colorant, and a release agent, the crystalline polyester resin comprising: an alicyclic dibasic acid, a terephthalic acid, and an isophthalic acid as acid components, and the crystalline polyester resin being contained in the toner particle in an amount of 4 to 8% by mass. an alicyclic dibasic acid, a terephthalic acid, and an isophthalic acid as acid components, and the crystalline polyester resin being contained in the toner particle in an amount of 4 to 8% by mass.
A gestational stage porcine splenic organ or splenic tissue graft for use in the treatment of a disease or disorder selected from the group consisting of a coagulation disorder, a coagulation factor deficiency, a defect in lymphoid stroma, an immunity-associated disorder and a lysosomal storage disease/enzyme deficiency, said porcine splenic organ or splenic tissue graft selected not expressing or presenting at least one molecule capable of stimulating or enhancing an immune response in a xenogeneic subject, wherein said at least one molecule is a lymphocyte coreceptor or lymphocyte coreceptor ligand, and wherein said stage of differentiation of said porcine splenic organ or splenic tissue graft corresponds to porcine 20 to 63 days of gestation.
Mounting device for a stand device for arranging in the operating theatre and for locally positioning or displacing a medical-technical device in the operating theatre, in particular by means of a rotary movement, comprising - a mounting unit, which extends in a longitudinal direction along an axis of rotation, and has a cavity which is aligned in the longitudinal direction, in particular a cylindrical cavity, for accomodating a rotatably supportable connecting member of the stand device; - an adjustment means for arranging said connecting member in a predefined position relative to said mounting unit; wherein the mounting device forms a rotational coupling adjustable around the axis of rotation for supporting the connecting member on the mounting unit, characterised in that the mounting device has an axial lock by means of which the connecting member can be mounted on the mounting unit in a predefined axial position, and that the axial lock comprises a passage arranged tangentially on the mounting unit, which passage passes through an outer surface of the mounting unit and which intersects an inner surface of the mounting unit surrounding the cavity. - a mounting unit, which extends in a longitudinal direction along an axis of rotation, and has a cavity which is aligned in the longitudinal direction, in particular a cylindrical cavity, for accomodating a rotatably supportable connecting member of the stand device; - an adjustment means for arranging said connecting member in a predefined position relative to said mounting unit;
A cable pulley, in particular for a pulley assembly of a cableway installation, with a pulley body mounted rotatably about a bearing journal by at least one rotary bearing and having two side cheeks (4a, 4b) and a running ring for receiving a running surface, characterised in that the running ring is formed in one piece with at least one side cheek (4a, 4b) and is releasably connected to the pulley body.