Danazol or a pharmacologically-acceptable salt or ester thereof or (ii) a steroid of formula (IVa) or a pharmacologically-acceptable salt or ester thereof for use in the treatment of an angiogenic brain disease or angiogenic condition of the brain: wherein: R 18, R 19 and R 21 are the same or different and each is hydrogen or an alkyl group having from 1 to 6 carbon atoms; R 17 is hydrogen, an alkyl group having from 1 to 6 carbon atoms or an alkenyl group having from 2 to 6 carbon atoms, R 22 is hydroxyl, an alkoxy group having from 1 to 6 carbon atoms, an alkanoyloxy group having from 1 to 7 carbon atoms, a group of formula or a group of formula: wherein R 11 is hydrogen, an alkyl group having from 1 to 6 carbon atoms, a hydroxyl group, an alkoxy group having from 1 to 6 carbon atoms or a group of formula -N(R 14) 2 wherein each group R 14 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, each of R 12 and R 13 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, and m and n are the same or different and each is 0 or an integer of from 1 to 4; R 17 and R 22 together represent an oxo group, an ethylenedioxy group or a propylenedioxy group; each of R 20 and R 24 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms or R 20 and R 24 together represent a single bond; each of R 23 and R 29 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms or R 23 and R 29 together represent an epoxy linkage; each of R 25, R 26, R 27 and R 28 is the same or different and is hydrogen, an alkyl group having from 1 to 6 carbon atoms, a cyano group, a hydroxyl group, an alkoxy group having from 1 to 6 carbon atoms or a group of formula -N(R 30) 2 wherein each group R 30 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, or R 25 and R 26 and/or R 27 and R 28 together with the carbon atom to which they are attached represent a carbonyl group, or R 25, R 26, R 27 and R 28 together with the carbon atoms to which they are attached represent a 5- to 9-membered heterocyclic group, said 5- to 9-membered heterocyclic group optionally being substituted with from 1 to 7 substituents, which may be the same or different, and are selected from substituent group α; and substituent group a is a group consisting of a halogen atom, a hydroxyl group, a cyano group, an amino group, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms, an alkylsulfinyl group having from 1 to 6 carbon atoms, an alkylsulfonyl group having from 1 to 6 carbon atoms, a phenyl group and a group of formula -N(R 16) 2 wherein each group R 16 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms. R 18, R 19 and R 21 are the same or different and each is hydrogen or an alkyl group having from 1 to 6 carbon atoms; R 17 is hydrogen, an alkyl group having from 1 to 6 carbon atoms or an alkenyl group having from 2 to 6 carbon atoms, R 22 is hydroxyl, an alkoxy group having from 1 to 6 carbon atoms, an alkanoyloxy group having from 1 to 7 carbon atoms, a group of formula or a group of formula: wherein R 11 is hydrogen, an alkyl group having from 1 to 6 carbon atoms, a hydroxyl group, an alkoxy group having from 1 to 6 carbon atoms or a group of formula -N(R 14) 2 wherein each group R 14 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, each of R 12 and R 13 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, and m and n are the same or different and each is 0 or an integer of from 1 to 4; R 17 and R 22 together represent an oxo group, an ethylenedioxy group or a propylenedioxy group; each of R 20 and R 24 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms or R 20 and R 24 together represent a single bond; each of R 23 and R 29 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms or R 23 and R 29 together represent an epoxy linkage; each of R 25, R 26, R 27 and R 28 is the same or different and is hydrogen, an alkyl group having from 1 to 6 carbon atoms, a cyano group, a hydroxyl group, an alkoxy group having from 1 to 6 carbon atoms or a group of formula -N(R 30) 2 wherein each group R 30 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms, or R 25 and R 26 and/or R 27 and R 28 together with the carbon atom to which they are attached represent a carbonyl group, or R 25, R 26, R 27 and R 28 together with the carbon atoms to which they are attached represent a 5- to 9-membered heterocyclic group, said 5- to 9-membered heterocyclic group optionally being substituted with from 1 to 7 substituents, which may be the same or different, and are selected from substituent group α; and substituent group a is a group consisting of a halogen atom, a hydroxyl group, a cyano group, an amino group, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms, an alkylsulfinyl group having from 1 to 6 carbon atoms, an alkylsulfonyl group having from 1 to 6 carbon atoms, a phenyl group and a group of formula -N(R 16) 2 wherein each group R 16 is the same or different and is hydrogen or an alkyl group having from 1 to 6 carbon atoms.