Tyre for wheels of vehicles having a tread band in which a tread pattern is defined which comprises: a) two substantially circumferential grooves (12, 13) having width of at least 8 mm, which define on said tread band a first and a second shoulder region and a central region extending across an equatorial plane of said tyre, wherein said central region has a width equal to at least 30% of an effective width of said tread band; b) a plurality of transverse grooves (25, 26, 27, 28) which define, together with said substantially circumferential grooves (12, 13), a plurality of blocks in said central region, said first shoulder region and said second shoulder region wherein said plurality of transverse grooves comprises a plurality of first transverse grooves extending over the entire width of said central region and a plurality of second transverse grooves arranged between said first transverse grooves; wherein at least some of the first transverse grooves in said central region have a substantially U-shaped, or V-shaped, configuration. c) a first plurality of sipes formed in said blocks of said central region;wherein the sipes of said first plurality of sipes have an oblique average inclination relative to a circumferential direction, said average inclination being alternated in the circumferential direction so as to form at least one sequence of inclined and counter-inclined sipes in at least some circumferentially adjacent blocks of said central region; and wherein said transverse grooves (25, 26) define, in said central region, at least one module of blocks (M1, M2) which is substantially repeated in succession along the circumferential direction, said at least one module comprising at least two circumferentially adjacent blocks and wherein a succession of a first module and a second module substantially identical to the first module and overturned by 180° is repeated substantially along the circumferential direction. a) two substantially circumferential grooves (12, 13) having width of at least 8 mm, which define on said tread band a first and a second shoulder region and a central region extending across an equatorial plane of said tyre, wherein said central region has a width equal to at least 30% of an effective width of said tread band; b) a plurality of transverse grooves (25, 26, 27, 28) which define, together with said substantially circumferential grooves (12, 13), a plurality of blocks in said central region, said first shoulder region and said second shoulder region wherein said plurality of transverse grooves comprises a plurality of first transverse grooves extending over the entire width of said central region and a plurality of second transverse grooves arranged between said first transverse grooves; wherein at least some of the first transverse grooves in said central region have a substantially U-shaped, or V-shaped, configuration. c) a first plurality of sipes formed in said blocks of said central region;wherein the sipes of said first plurality of sipes have an oblique average inclination relative to a circumferential direction, said average inclination being alternated in the circumferential direction so as to form at least one sequence of inclined and counter-inclined sipes in at least some circumferentially adjacent blocks of said central region; and wherein said transverse grooves (25, 26) define, in said central region, at least one module of blocks (M1, M2) which is substantially repeated in succession along the circumferential direction, said at least one module comprising at least two circumferentially adjacent blocks