mhurhangee/ep-ind-claims huggingface dataset:
An acylfulvene analog of Table 14 selected from the group consisting of analogs 002, 003, 004, 005, 006, 007, 008, 009, 010, 011, 012, 013, 015, 016, 017, 018, 019, 020, 021, 022, 023, 024, 025, 026, 027, 028, 029, 030, 031, 032, 034, 036, 037, 038, 039, 040, 041, 043, 046, 047, 048, 049, 050, 051, 052, 053, 054, 056, 057, 058, 062, 063, 064, 065, 066, 074, 075, 076, 077, 078, 079, 080, 081, 082, 083, 084, 085, 086, 087, 088, 089, 090, 093, 094, 095, 096, 097, 098, 100, 101, 102, 103, 108, 110, 111, 112, 113, 114, 115, 116, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 159, 164, 165, 175, 176, 177, 178, 179, 184, 185, 187, 188, 189, 190, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 217, 220, 221, 223, 226, 227, 229, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 301, 304, 305, 306, 310, 314, 315, 332, 336, 337, 338, 339, 340, 354, 366, and 367 for use in the treatment of a cancerous tumor expressing: (i) one or more PTGR genes; and (ii) a MYC gene; and (iii) one or more Transcriptional-Coupled Repair genes selected from the group consisting of ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L, ERCC6L2, ERCC8, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, RAD18, XPA, XPC, USP7, UVSSA, in a patient, wherein said expressing comprises: (a) increased expression of the one or more PTGR genes compared to a housekeeping gene in the cancerous tumor; (b) increased expression of the MYC gene compared to a housekeeping gene in the cancerous tumor; and (c) decreased expression of the one or more TCR genes compared with a housekeeping gene in the cancerous tumor. (i) one or more PTGR genes; and (ii) a MYC gene; and (iii) one or more Transcriptional-Coupled Repair genes selected from the group consisting of ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L, ERCC6L2, ERCC8, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, RAD18, XPA, XPC, USP7, UVSSA, in a patient, wherein said expressing comprises: (a) increased expression of the one or more PTGR genes compared to a housekeeping gene in the cancerous tumor; (b) increased expression of the MYC gene compared to a housekeeping gene in the cancerous tumor; and (c) decreased expression of the one or more TCR genes compared with a housekeeping gene in the cancerous tumor. (a) increased expression of the one or more PTGR genes compared to a housekeeping gene in the cancerous tumor; (b) increased expression of the MYC gene compared to a housekeeping gene in the cancerous tumor; and (c) decreased expression of the one or more TCR genes compared with a housekeeping gene in the cancerous tumor.
A method of extinguishing an electric arc in a low or high voltage switchgear by pulse discharge characterized by: - cutting the electric arc by supplying a higher voltage than the arc voltage to the both ends of the electric arc to be cut off at the moment when it occurs, by means of a nonpolar condenser, which is fully precharged up to the maximum of the supply voltage, when the switchgear is in switching-in state, - wherein said nonpolar condenser is directly discharged across the both ends of the electric arc, when the switchgear is in switched-off state, - introducing auxiliary contacts (206, 207, 208, 209) to extinguish the electric arc by pulse discharging of said nonpolar condenser by linking the auxiliary contact to the moving arcing contact and an intermediate contact-maker by installing between the fixed primary contact and the moving arcing contact are to follow the motion of the moving arcing contact, so that in the switching-in state of the switchgear a nonpolar condenser is not connected to both ends of the contact portion of the fixed contact and the moving contact, or of the fixed contact and the intermediate contact-maker, and its charging circuit is closed. - cutting the electric arc by supplying a higher voltage than the arc voltage to the both ends of the electric arc to be cut off at the moment when it occurs, by means of a nonpolar condenser, which is fully precharged up to the maximum of the supply voltage, when the switchgear is in switching-in state, - wherein said nonpolar condenser is directly discharged across the both ends of the electric arc, when the switchgear is in switched-off state, - introducing auxiliary contacts (206, 207, 208, 209) to extinguish the electric arc by pulse discharging of said nonpolar condenser by linking the auxiliary contact to the moving arcing contact and an intermediate contact-maker by installing between the fixed primary contact and the moving arcing contact are to follow the motion of the moving arcing contact, so that in the switching-in state of the switchgear a nonpolar condenser is not connected to both ends of the contact portion of the fixed contact and the moving contact, or of the fixed contact and the intermediate contact-maker, and its charging circuit is closed.
A method for sending a power headroom report, PHR, by a user equipment, UE, (102, 402, 502) comprising: in a configuration of Dual Connectivity, operating two media access control, MAC, entities (539a, 539b), wherein (i) a first MAC entity of the MAC entities (539a, 539b) corresponds to a first set of serving cells, and (ii) a second MAC entity of the MAC entities (539a, 539b) corresponds to a second set of serving cells; generating, in each of the MAC entities (539a, 539b), an extended power headroom MAC control element for the Dual Connectivity that includes a value of a power headroom for each activated serving cell with configured uplink among the first set and the second set of serving cells; and transmitting, in each of the MAC entities (539a, 539b), the extended power headroom MAC control element for the Dual Connectivity. in a configuration of Dual Connectivity, operating two media access control, MAC, entities (539a, 539b), wherein (i) a first MAC entity of the MAC entities (539a, 539b) corresponds to a first set of serving cells, and (ii) a second MAC entity of the MAC entities (539a, 539b) corresponds to a second set of serving cells; generating, in each of the MAC entities (539a, 539b), an extended power headroom MAC control element for the Dual Connectivity that includes a value of a power headroom for each activated serving cell with configured uplink among the first set and the second set of serving cells; and transmitting, in each of the MAC entities (539a, 539b), the extended power headroom MAC control element for the Dual Connectivity.
Method for transferring a first sample liquid from a first primary vessel into a first target vessel and a second sample liquid from a second primary vessel into a second target vessel with the aid of at least one automated pipetting apparatus comprising a system liquid in an automated analysis machine comprising a control machine, comprising the following steps: a) receiving a first liquid volume V1 of the first sample liquid with the aid of the pipetting apparatus from the first primary vessel, b) dispensing the first liquid volume V1 of the first sample liquid with the aid of the pipetting apparatus into an aliquot vessel, c) receiving a second liquid volume V2 of the first sample liquid with the aid of the pipetting apparatus from the aliquot vessel, d) dispensing the second liquid volume V2 of the first sample liquid with the aid of the pipetting apparatus into the first target vessel, e) receiving a third liquid volume V3 of the second sample liquid with the aid of the pipetting apparatus from the second primary vessel, f) dispensing the third liquid volume V3 of the second sample liquid with the aid of the pipetting apparatus into the second target vessel, characterized in that the third liquid volume V3 of the second sample liquid is automatically ascertained with the aid of the control machine in accordance with the following relationship: V 3 = a V 2 + b, where V2 denotes the second liquid volume of the first sample liquid, a denotes a predetermined liquid-volume-dependent correction factor and b denotes a predetermined liquid-volume-independent correction factor and where the correction factor a is unequal to one. a) receiving a first liquid volume V1 of the first sample liquid with the aid of the pipetting apparatus from the first primary vessel, b) dispensing the first liquid volume V1 of the first sample liquid with the aid of the pipetting apparatus into an aliquot vessel, c) receiving a second liquid volume V2 of the first sample liquid with the aid of the pipetting apparatus from the aliquot vessel, d) dispensing the second liquid volume V2 of the first sample liquid with the aid of the pipetting apparatus into the first target vessel, e) receiving a third liquid volume V3 of the second sample liquid with the aid of the pipetting apparatus from the second primary vessel, f) dispensing the third liquid volume V3 of the second sample liquid with the aid of the pipetting apparatus into the second target vessel,
An antibody or antibody fragment for specifically recognizing and binding to an ED-B domain of human fibronectin, characterized in that the antibody or antibody fragment comprises a heavy-chain variable region having the amino acid sequence as shown in SEQ ID NO: 1 and a light-chain variable region having the amino acid sequence as shown in SEQ ID NO: 3.
A process for the obtention of a compound of the formula R1-C X having a reduced content of impurities, wherein R1 is selected from the group consisting of CF 3, CClF 2 and CHF 2 X is a Cl, which comprises a) subjecting a crude fraction comprising compound of formula R1-C X and impurities to at least three distillation steps, which consist of a high pressure distillation step, a medium pressure distillation step and a low pressure distillation step carried out at different pressures, wherein the high pressure distillation step and the medium pressure distillation step carried out at a pressure of at least 1 bar lower than the high pressure distillation step, and the low pressure distillation step carried out at a pressure of at least 0,2 bar lower than the medium pressure distillation step and b) recovering at least a fraction of the compound of the formula having a reduced content of impurities.
A system for monitoring tilled floor conditions within a field, the system comprising a sensor frame, the system characterized by: a tilled floor sensing assembly supported on the sensor frame, the tilled floor sensing assembly comprising: a plurality of pins configured to be extended relative to the sensor frame such that each pin penetrates a top surface of the field; a plurality of position sensors, each position sensor configured to capture data indicative of a position of a given pin of the plurality of pins relative to the sensor frame; and a plurality of force sensors, each force sensor configured to capture data indicative of a force being applied to a given pin of the plurality of pins, wherein the data captured by the plurality of position sensors and the data captured by the plurality of force sensors is indicative of a tilled floor profile of the field. a plurality of pins configured to be extended relative to the sensor frame such that each pin penetrates a top surface of the field; a plurality of position sensors, each position sensor configured to capture data indicative of a position of a given pin of the plurality of pins relative to the sensor frame; and a plurality of force sensors, each force sensor configured to capture data indicative of a force being applied to a given pin of the plurality of pins, wherein the data captured by the plurality of position sensors and the data captured by the plurality of force sensors is indicative of a tilled floor profile of the field.
Method for operating an accessory device that is designed to be electrically and/or mechanically connected to a master device over a predefined physical link, wherein a control unit of the accessory device sends out a first device identifier of the accessory device over a predefined radio interface for establishing a radio link to the master device, when the control unit is switched on, characterized in that the control unit observes a connection status of the physical link and, if a disconnection of the physical link is detected, the next time the control unit is switched on, the control unit changes the first device identifier into a second device identifier according to a predefined changing pattern and sends out the second device identifier over the radio interface.
A filter manufacturing apparatus comprising: a transfer path through which filter elements: for a smoking article is transferred; and an additive feeding unit provided immediately above the transfer path to feed a granular additive to each of the filter elements or among the filter elements on the transfer path, characterized in that the additive feeding unit includes a classifier classifying the additive into coarse grains and fine grains based on granularity to remove the fine grains immediately before feeding the additive to each of the filter elements or among the filter elements. a transfer path through which filter elements: for a smoking article is transferred; and an additive feeding unit provided immediately above the transfer path to feed a granular additive to each of the filter elements or among the filter elements on the transfer path, characterized in that the additive feeding unit includes a classifier classifying the additive into coarse grains and fine grains based on granularity to remove the fine grains immediately before feeding the additive to each of the filter elements or among the filter elements.
A hand-held hot melt glue gun comprising a melt chamber, a needle and a nozzle movable with respect to said needle operative to open or close a discharge port in fluid communication with said melt chamber, a closure element that urges said needle and nozzle toward relative positions where said discharge port is closed, an opening element for moving said nozzle with respect to said needle to relative positions where said discharge port is open, and a trigger mechanism (40, 50, 52) for advancing solid glue into said melt chamber and for operating said opening element, wherein said trigger mechanism (40, 50, 52) provides a time delay between opening of said discharge port and advancement of said glue into said melt chamber.
A display device to sense an input point using magnetic fluid, the display device comprising: a touch panel part to receive a user input through a touch at an input point and to calculate a coordinate value of the input point; an electromagnet arrangement part comprising a plurality of electromagnets to generate a magnetic force on one or more electromagnets in a portion corresponding to the coordinate value; and a magnetic fluid part to become magnetized at the portion corresponding to the coordinate value and to project in accordance with the generated magnetic force. a touch panel part to receive a user input through a touch at an input point and to calculate a coordinate value of the input point; an electromagnet arrangement part comprising a plurality of electromagnets to generate a magnetic force on one or more electromagnets in a portion corresponding to the coordinate value; and a magnetic fluid part to become magnetized at the portion corresponding to the coordinate value and to project in accordance with the generated magnetic force.
A method for producing upconverting nanoparticles, the method comprising steps of: - admixing two or more rare earth salts in a first solvent and an organic oil to form a reaction mixture in a reaction vessel, - subjecting the reaction mixture to a flow of an inert gas, wherein flow rate of the inert gas is 2-5 L/h, preferably 4-5 L/h, most preferably 4.8 L/h, and pressure in the reaction vessel is at least 50 Pa over atmospheric pressure, preferably 50-80 Pa over atmospheric pressure, - heating the reaction mixture from a first temperature to a second temperature, wherein the first temperature is 15-25 °C and the second temperature is 150-200 °C, preferably 160 °C, - cooling the reaction mixture from the second temperature to a third temperature, wherein the third temperature is preferably 15-60 °C, - admixing to the reaction mixture fluoride ion and sodium ion in a second solvent, and - heating the reaction mixture from the third temperature to a fourth temperature, wherein the fourth temperature is preferably 250-350 °C, more preferably 300-320 °C. - admixing two or more rare earth salts in a first solvent and an organic oil to form a reaction mixture in a reaction vessel, - subjecting the reaction mixture to a flow of an inert gas, wherein flow rate of the inert gas is 2-5 L/h, preferably 4-5 L/h, most preferably 4.8 L/h, and pressure in the reaction vessel is at least 50 Pa over atmospheric pressure, preferably 50-80 Pa over atmospheric pressure, - heating the reaction mixture from a first temperature to a second temperature, wherein the first temperature is 15-25 °C and the second temperature is 150-200 °C, preferably 160 °C, - cooling the reaction mixture from the second temperature to a third temperature, wherein the third temperature is preferably 15-60 °C, - admixing to the reaction mixture fluoride ion and sodium ion in a second solvent, and - heating the reaction mixture from the third temperature to a fourth temperature, wherein the fourth temperature is preferably 250-350 °C, more preferably 300-320 °C.
A single-chain fusion polypeptide comprising: (i) a first soluble TNF family cytokine domain, (ii) a first peptide linker, (iii) a second soluble TNF family cytokine domain, (iv) a second peptide linker, and (v) a third soluble TNF family cytokine domain, wherein the fusion polypeptide is substantially non-aggregating, wherein the soluble TNF family cytokine domain is selected from soluble CD95L domains. (i) a first soluble TNF family cytokine domain, (ii) a first peptide linker, (iii) a second soluble TNF family cytokine domain, (iv) a second peptide linker, and (v) a third soluble TNF family cytokine domain,
Apparatus for downmixing a multi-channel signal comprising at least two channels (101, 102), comprising: a downmixer for calculating a downmix signal from the multi-channel signal, wherein the downmixer is configured to calculate the downmix using an absolute phase compensation, so that a channel having a lower energy among the at least two channels is only rotated or is rotated stronger than a channel having a greater energy in calculating the downmix signal; and an output interface for generating an output signal, the output signal comprising information on the downmix signal. a downmixer for calculating a downmix signal from the multi-channel signal, wherein the downmixer is configured to calculate the downmix using an absolute phase compensation, so that a channel having a lower energy among the at least two channels is only rotated or is rotated stronger than a channel having a greater energy in calculating the downmix signal; and an output interface for generating an output signal, the output signal comprising information on the downmix signal.
A catheter useful for non-surgical entry into an uterus to dispense a diagnostic fluid therein and to the fallopian tubes and to retrieve a sample from said dispensed fluid, the catheter comprising: an elongated body having three lumens (4, 5 and 6), a balloon disposed adjacent to the distal end of the elongated body for fluid sealing the interior of the subject's uterus; wherein two lumens (4 and 5) extend from the proximal end up to the distal end of the elongated body, and the third lumen extends from the proximal end to an opening to inflate the balloon, characterized in that the first lumen has an opening at the top of the tip at the distal end of the elongated body for dispensing a diagnostic fluid into the interior of a subject's uterus; the second lumen has an opening at the top of the tip at the distal end of the elongated body for retrieving a sample of said dispensed fluid of the interior of a subject's uterus, wherein the elongated body is devoid of additional openings between the balloon and the proximal end of the elongated body". an elongated body having three lumens (4, 5 and 6), a balloon disposed adjacent to the distal end of the elongated body for fluid sealing the interior of the subject's uterus; wherein two lumens (4 and 5) extend from the proximal end up to the distal end of the elongated body, and the third lumen extends from the proximal end to an opening to inflate the balloon, characterized in that the first lumen has an opening at the top of the tip at the distal end of the elongated body for dispensing a diagnostic fluid into the interior of a subject's uterus; the second lumen has an opening at the top of the tip at the distal end of the elongated body for retrieving a sample of said dispensed fluid of the interior of a subject's uterus, wherein the elongated body is devoid of additional openings between the balloon and the proximal end of the elongated body".
A system comprising: an RF generator, and a controller for multiple independent RF switch control, wherein the controller is configured for repeating and/or reconfiguring a network topology of a number N of RF switch connections, SW1 to SWN, to a target at N target nodes for RF current flowing in a predetermined pattern, within a cycle and subsequent cycles by operably maintaining or changing connections to a plurality of electrodes (E1, E2,..., EN) to respond to temperature and heating requirements of any of the one or more electrodes (E1, E2,..., EN) at any instant; and wherein changing the connections causes RF current to flow in another predetermined pattern, characterized in that at least one of the plurality of electrodes is connected to excitation voltage of the RF generator and two or more of the remaining two or more electrodes of the plurality of electrodes (E1, E2,..., EN) are combined to form a low impedance return path electrode for the RF current. an RF generator, and a controller for multiple independent RF switch control, wherein the controller is configured for repeating and/or reconfiguring a network topology of a number N of RF switch connections, SW1 to SWN, to a target at N target nodes for RF current flowing in a predetermined pattern, within a cycle and subsequent cycles by operably maintaining or changing connections to a plurality of electrodes (E1, E2,..., EN) to respond to temperature and heating requirements of any of the one or more electrodes (E1, E2,..., EN) at any instant; and wherein changing the connections causes RF current to flow in another predetermined pattern, characterized in that at least one of the plurality of electrodes is connected to excitation voltage of the RF generator and two or more of the remaining two or more electrodes of the plurality of electrodes (E1, E2,..., EN) are combined to form a low impedance return path electrode for the RF current.