mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for diagnosing an auto-immune-mediated necrotizing myopathy in a mammalian subject by determining the presence of autoantibodies specific for a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) protein or a fragment thereof having anti-HMGCR autoantibody binding activity in the subject comprising the steps of: a) performing an immunoassay by contacting a biological sample obtained from the subject with a HMGCR protein or a fragment thereof having anti-HMGCR autoantibody binding activity, b) detecting the presence of auto-antibodies in the sample which specifically bind the HMGCR protein or the fragment thereof having anti-HMGCR autoantibody binding activity, wherein the presence of autoantibodies which specifically bind the HMGCR protein or the fragment thereof having anti-HMGCR autoantibody binding activity is indicative that the subject has the myopathy. a) performing an immunoassay by contacting a biological sample obtained from the subject with a HMGCR protein or a fragment thereof having anti-HMGCR autoantibody binding activity, b) detecting the presence of auto-antibodies in the sample which specifically bind the HMGCR protein or the fragment thereof having anti-HMGCR autoantibody binding activity, wherein the presence of autoantibodies which specifically bind the HMGCR protein or the fragment thereof having anti-HMGCR autoantibody binding activity is indicative that the subject has the myopathy.
A bore selection device for use with a dual bore sub-sea system, said bore selection device comprising: a housing having a longitudinal axis, said housing defining a production bore and an annulus bore, said production bore being of a diameter larger than said annulus bore and extending the length of the housing, said annulus bore extending part-way along the length of said housing; bore selector means movable between a first position wherein the production bore is open and said annulus bore is closed and a second position wherein the production bore is closed and said annulus bore is open; the bore selector means being coupled to actuation means (24a,24b) by coupling means (26a,26b), said actuation means (24a,24b) and coupling means (26a,26b) being disposed in said housing, said actuation means (24a,24b) being movable substantially parallel to said production bore, characterised by: said coupling means (26a,26b) coupling said actuation means (24a,24b) to said bore selector means to transform longitudinal movement of said actuation means (24a,24b) to transverse movement of said bore selector means to said production bore whereby said bore selector means is moved between said first and said second positions. a housing having a longitudinal axis, said housing defining a production bore and an annulus bore, said production bore being of a diameter larger than said annulus bore and extending the length of the housing, said annulus bore extending part-way along the length of said housing; bore selector means movable between a first position wherein the production bore is open and said annulus bore is closed and a second position wherein the production bore is closed and said annulus bore is open; the bore selector means being coupled to actuation means (24a,24b) by coupling means (26a,26b), said actuation means (24a,24b) and coupling means (26a,26b) being disposed in said housing, said actuation means (24a,24b) being movable substantially parallel to said production bore, characterised by: said coupling means (26a,26b) coupling said actuation means (24a,24b) to said bore selector means to transform longitudinal movement of said actuation means (24a,24b) to transverse movement of said bore selector means to said production bore whereby said bore selector means is moved between said first and said second positions. said coupling means (26a,26b) coupling said actuation means (24a,24b) to said bore selector means to transform longitudinal movement of said actuation means (24a,24b) to transverse movement of said bore selector means to said production bore whereby said bore selector means is moved between said first and said second positions.
A method for forming a product comprising a cyclic siloxane compound, where the method comprises: 1) combining, at a temperature of at least 200°C, (a) an organodihalosilane of formula R 1 2 SiX 2, where each R 1 is independently a hydrogen atom, a halogenated hydrocarbyl group or a hydrocarbyl group; and each X is independently a halogen atom; and (c) a transition metal on cerium oxide catalyst, where the transition metal is selected from Rhenium, Iron, Nickel, and Copper; thereby producing the product comprising the cyclic siloxane compound. 1) combining, at a temperature of at least 200°C, (a) an organodihalosilane of formula R 1 2 SiX 2, where each R 1 is independently a hydrogen atom, a halogenated hydrocarbyl group or a hydrocarbyl group; and each X is independently a halogen atom; and (c) a transition metal on cerium oxide catalyst, where the transition metal is selected from Rhenium, Iron, Nickel, and Copper; thereby producing the product comprising the cyclic siloxane compound. (a) an organodihalosilane of formula R 1 2 SiX 2, where each R 1 is independently a hydrogen atom, a halogenated hydrocarbyl group or a hydrocarbyl group; and each X is independently a halogen atom; and (c) a transition metal on cerium oxide catalyst, where the transition metal is selected from Rhenium, Iron, Nickel, and Copper;
A process which comprises brominating an aromatic polymer composition of the formula: wherein n is an average number in the range of 2.5 to 8 with the proviso that 1,3-diphenylpropane, a compound of formula in which n is 0, optionally is present in this aromatic polymer composition in an amount of not more than 1 GPC area %, and with the further proviso that this aromatic polymer composition optionally further contains toluene in an amount of not more than 0.1 GPC area %, to form a brominated aromatic polymer composition having a bromine content as determined by XRF in the range of 70 to 76 weight percent, which process comprises brominating said aromatic polymer composition with liquid bromine in the presence of an aluminum halide bromination catalyst and in the absence of light, at a bromination temperature in the range of -10°C to +5°C, and in which the molar ratio of total amount of bromine fed:total amount of catalyst fed is in the range of 200:1 to 500:1, which process is further characterized in that: a) the total amount of said catalyst is charged into a reactor which is at a temperature in the range of -25°C to 0°C, said reactor containing an inert atmosphere and a portion of bromination solvent such that the initial weight percentage of said catalyst expressed as aluminum is in the range of 0.02 wt% to 0.04 wt%; b) within 2 hours after completing the charge of the catalyst, separate concurrent feeds of (i) bromine, and (ii) a solution of said aromatic polymer composition in the bromination solvent are initiated, said feeds being conducted such that said solution and the liquid bromine are fed to maintain a substantially constant molar ratio of aromatic polymer composition to bromine entering the reactor; and c) wherein on completion of the feeds and an optional ride time of no greater than 60 minutes, the weight percentage of aluminum relative to the total of the mass of the bromination solvent and the brominated aromatic polymer composition in the reactor is greater than 0.015 wt%. a) the total amount of said catalyst is charged into a reactor which is at a temperature in the range of -25°C to 0°C, said reactor containing an inert atmosphere and a portion of bromination solvent such that the initial weight percentage of said catalyst expressed as aluminum is in the range of 0.02 wt% to 0.04 wt%; b) within 2 hours after completing the charge of the catalyst, separate concurrent feeds of (i) bromine, and (ii) a solution of said aromatic polymer composition in the bromination solvent are initiated, said feeds being conducted such that said solution and the liquid bromine are fed to maintain a substantially constant molar ratio of aromatic polymer composition to bromine entering the reactor; and c) wherein on completion of the feeds and an optional ride time of no greater than 60 minutes, the weight percentage of aluminum relative to the total of the mass of the bromination solvent and the brominated aromatic polymer composition in the reactor is greater than 0.015 wt%.
A manufacturing method of a head hardened rail comprising steel consisting of, in terms of mass%, C: 0.75% or more and 0.85% or less, Si: 0.5% or more and 1% or less, Mn: 0.5% or more and 1% or less, Cr: 0.5% or more and 1% or less and V: 0% or more and 0.01% or less, and in which the remainder consists of Fe and inevitable impurities, the method comprising forcibly cooling at least a head portion of a hot-rolled high-temperature rail or a heated high-temperature rail; wherein the forcible cooling is started from a state where a surface temperature of the head portion of the rail is not less than an austenite range temperature; and wherein the forcible cooling is performed at a cooling rate of 10°C/sec or more until the surface temperature reaches 500°C or more and 700°C or less after the forcible cooling is started; and after the forcible cooling is performed at the cooling rate of 10°C/sec or more until the surface temperature reaches 500°C or more and 700°C or less, the head portion is cooled at a cooling rate of -5°C/sec or more and 5°C/sec or less until pearlite transformation finishes, and after performing the forcible cooling at a cooling rate of -5°C/sec or more and 5°C/sec or less until the pearlite transformation finishes, the forcible cooling is performed at a cooling rate of 1°C/sec or more and 15°C/sec or less until the surface temperature reaches 50°C or more and 450°C or less.
A xylanase variant, comprising a substitution at least at one position corresponding to position 87 of the polypeptide of SEQ ID NO: 3, wherein the variant has xylanase activity and has increased xylanase inhibitor tolerance compared to the xylanase of SEQ ID NO: 3; and wherein the variant has at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100% sequence identity to the polypeptide of SEQ ID NO: 3 and wherein the substitution is H87Y.
An ophthalmic composition useful for the treatment of keratoconus to be administered by corneal iontophoresis, wherein the cross-linking agent is riboflavin, characterized in that the pH is between 6.9 and 7.2, and the value of osmolarity is between 90 and 100 mOsm/l, and the following formulation: Riboflavin sodium phosphate 0.147 g Sodium-EDTA 0.1 g Tris-(hydroxymethyl)aminomethane 0.05 g NaH 2 PO 4.2H 2 O 0.385 g Na 2 HPO 4.2H 2 O 0.217 g Distilled water up to 100 g.
A work vehicle, being an articulated type in which a front frame and a rear frame are linked, the work vehicle comprising: a hydraulic actuator (21, 22) driven hydraulically and configured to change a steering angle (θs) of the front frame with respect to the rear frame; a joystick lever configured to be operated by an operator; a control valve linked to the joystick lever, and configured to control flow of fluid supplied to the hydraulic actuator (21, 22) according to an operation amount of the joystick lever, and restrict the operation amount of the joystick lever to a predetermined range; characterized by a force imparting component configured to impart an assist force or a counterforce to the operation of the joystick lever by the operator; and a controller configured to control the force imparting component so as to decrease the assist force or increase the counterforce before the operation of the joystick lever is restricted by the control valve. a hydraulic actuator (21, 22) driven hydraulically and configured to change a steering angle (θs) of the front frame with respect to the rear frame; a joystick lever configured to be operated by an operator; a control valve linked to the joystick lever, and configured to control flow of fluid supplied to the hydraulic actuator (21, 22) according to an operation amount of the joystick lever, and restrict the operation amount of the joystick lever to a predetermined range; characterized by a force imparting component configured to impart an assist force or a counterforce to the operation of the joystick lever by the operator; and a controller configured to control the force imparting component so as to decrease the assist force or increase the counterforce before the operation of the joystick lever is restricted by the control valve.
A compound of Formula I: L is in the meta or para position of the phenyl ring; L is (CH 2) 1-2 and R 1 is selected from the group consisting of nitrogen-containing 5-7 membered heterocycloalkyl and NR 9 R 10, or L is (CH 2) 1-5 NH and R 1 is a C 5-7 cycloalkyl; wherein the nitrogen-containing 5-7 membered heterocycloalkyl is optionally substituted with a C 1 -C 6 alkyl group; R 2 is a straight chain C 2-4 alkanediyl; R 3 is H; R 4 is a straight chain C 2-4 -alkanediyl; R 9 and R 10 are independently C 1-6 alkyl; X is NR 6 2, wherein the R 6 groups together with the N atom to which they are attached form pyrrolidin-1-yl; and salts, hydrates and solvates thereof. L is in the meta or para position of the phenyl ring; L is (CH 2) 1-2 and R 1 is selected from the group consisting of nitrogen-containing 5-7 membered heterocycloalkyl and NR 9 R 10, or L is (CH 2) 1-5 NH and R 1 is a C 5-7 cycloalkyl; wherein the nitrogen-containing 5-7 membered heterocycloalkyl is optionally substituted with a C 1 -C 6 alkyl group; R 2 is a straight chain C 2-4 alkanediyl; R 3 is H; R 4 is a straight chain C 2-4 -alkanediyl; R 9 and R 10 are independently C 1-6 alkyl; X is NR 6 2, wherein the R 6 groups together with the N atom to which they are attached form pyrrolidin-1-yl; and salts, hydrates and solvates thereof.
An expression vector comprising: - a polynucleotide wherein the polynucleotide encodes the proteins E, prM and M of the West Nile Virus, and - the elements necessary for expression of the polynucleotide in a host cell, wherein the expression vector is a viral vector, further wherein the viral vector is a canarypox or fowlpox. - a polynucleotide wherein the polynucleotide encodes the proteins E, prM and M of the West Nile Virus, and - the elements necessary for expression of the polynucleotide in a host cell,
Pick-up device for picking up articles of the tobacco processing industry for a conveyor configured to convey these articles, comprising a body that can be moved in conveying direction, on the outer side of which are formed, preferably in a standardized arrangement, at least one first suction opening and at least one second suction opening (5a; 5c; 5d) at a distance from the first suction opening, with at least one pick-up element, comprising an outer side (6aa; 6ca; 6ea) for picking up at least one article, on which at least one first outer inlet and at least one second outer inlet are formed at a distance from the first outer inlet, and an inner side (6bc; 6cc; 6ec), by means of which the pick-up element can be disposed on the outer side of the movable body of the conveyor and on which at least one first outer outlet and at least one second outer outlet are formed, with at least one first connecting channel for connecting the first outer inlet with the first outer outlet on the pick-up element and at least one second connecting channel for connecting the second outer inlet to the second outer outlet on the pick-up element and with first fasteners for releasably securing at least one pick-up element on the outer side of the movable body of the conveyor, wherein the arrangement of the outer inlets (8a, 8b) on the outer side of the pick-up element and the configuration of the connecting channels (12a, 12b) are individually adapted to the format, in particular the length, of the article to be picked up, the outer outlets (18a, 18b) on the inner side of the pick-up element are provided independently of the respective format of the article to be picked up, preferably in a standardized arrangement, and at least one outer inlet is arranged offset relative to the associated outer outlet, in particular transverse to the conveying direction, and the connecting channel connecting these to one another is configured as a deflecting channel.
Thermally-insulated, corrugated conduit comprising at least one inner service pipe made from plastic or metal, wherein a thermal-insulating layer made of plastic surrounds the service pipe and an outer housing made of plastic surrounds the thermal-insulating layer, wherein the corrugation (25, 26) of the conduit extends into the thermal insulation layer, wherein the troughs and peaks of the corrugation have a round cross-sectional shape, wherein with an outer diameter of the conduit in the range of 63 mm to 202 mm, the corrugation depth T is in the range of 4.5 mm to 8 mm, wherein the round, cross-sectional form of the troughs and peaks in each case is part of a circle, wherein the circle portions are connected by substantially straight sections of the corrugation, characterized in that the radius of curvature RT of the troughs is greater than the radius of curvature RB of the peaks.
Device for spraying a cosmetic composition comprising a container equipped with a spraying mechanism comprising: - a perforated membrane, the perforations of the membrane enabling communication of the interior of the container with the external environment, - an actuator to make the membrane vibrate, characterized by the presence in the container of a liquid cosmetic composition, comprising, in a cosmetically acceptable medium, 0.1% to 40% by weight of at least one silicone, relative to the total weight of the cosmetic composition, and/or 0.1% to 40% by weight of at least one non-silicone fatty substance, relative to the total weight of the cosmetic composition, said cosmetic composition being contained in said container, of a means for bringing said liquid cosmetic composition into contact with an inner surface of the membrane, said cosmetic composition, under the effect of the vibrations of the membrane, flowing through the perforations up to an outer surface of the membrane, where it emerges in the form of droplets. - a perforated membrane, the perforations of the membrane enabling communication of the interior of the container with the external environment, - an actuator to make the membrane vibrate, characterized by the presence in the container of a liquid cosmetic composition, comprising, in a cosmetically acceptable medium, 0.1% to 40% by weight of at least one silicone, relative to the total weight of the cosmetic composition, and/or 0.1% to 40% by weight of at least one non-silicone fatty substance, relative to the total weight of the cosmetic composition, said cosmetic composition being contained in said container, of a means for bringing said liquid cosmetic composition into contact with an inner surface of the membrane, said cosmetic composition, under the effect of the vibrations of the membrane, flowing through the perforations up to an outer surface of the membrane, where it emerges in the form of droplets.
A printing apparatus comprising: a feeding roller configured to feed a printing sheet stacked on a stacking unit; a conveyance roller configured to convey the printing sheet fed by the feeding roller; printing means configured to print on the printing sheet conveyed by the conveyance roller; conveyance control means configured to control conveyance of printing sheets to form an overlap state in which a marginal area on trailing edge side of a preceding sheet (1-A) as a printing sheet precedingly fed from the stacking unit and a marginal area on leading edge side of a succeeding sheet (1-B) as a printing sheet succeedingly fed from the stacking unit overlap each other; and determination means configured to determine whether to convey the succeeding sheet (1-B), while keeping the overlap state, to a printing start position at which a printing operation by the printing means is started based on information regarding a conveyed position of the leading edge of the succeeding sheet (1-B), the conveyed position being a position of the leading edge of the succeeding sheet (1-B) in a state where the succeeding sheet (1-B) is conveyed to the printing start position. a feeding roller configured to feed a printing sheet stacked on a stacking unit; a conveyance roller configured to convey the printing sheet fed by the feeding roller; printing means configured to print on the printing sheet conveyed by the conveyance roller; conveyance control means configured to control conveyance of printing sheets to form an overlap state in which a marginal area on trailing edge side of a preceding sheet (1-A) as a printing sheet precedingly fed from the stacking unit and a marginal area on leading edge side of a succeeding sheet (1-B) as a printing sheet succeedingly fed from the stacking unit overlap each other; and determination means configured to determine whether to convey the succeeding sheet (1-B), while keeping the overlap state, to a printing start position at which a printing operation by the printing means is started based on information regarding a conveyed position of the leading edge of the succeeding sheet (1-B), the conveyed position being a position of the leading edge of the succeeding sheet (1-B) in a state where the succeeding sheet (1-B) is conveyed to the printing start position.