A compound of Formula, or a pharmaceutically acceptable salt thereof, wherein, R 2 is alkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl; X6 is C-H or N; X5 is C-R 5 or N; provided that if X6 is N, then X5 is C-R 5, and if X5 is N, then X6 is CH; R 5 is hydrogen, halogen, -OH, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 6 is hydrogen, halogen, -OH, -CN, alkyl, cycloalkyl, cycloalkylalkyl, amino, alkylamino, dialkylamino, cycloalkylalkylamino, alkoxy, -S-alkyl, cycloalkylalkoxy, heterocyclyl, aralkoxy, heteroaryloxy, aryloxy, alkynyloxy, or -N COalkyl; R A is X2 is N or C-R 12, wherein R 12 is hydrogen, halogen, alkyl, or alkoxy; R 13 is -Y-Z; Y is selected from a bond, -CH 2 -, or -CH(C 1 -C 4 alkyl)-; Z is selected from -SO 2 R 21, -N(R 22)SO 2 R 21, -SO 2 N(R 22) 2, -N(R 22)SO 2 N(R 22) 2, - CON(R 22) 2, -N(R 22)CO 2 R 21, -N(R 22)CON(R 22) 2, -N(R 22)COR 21, -COR 21,-OC N(R 22) 2, -OSO 2 N(R 22) 2, or -N(R 22)SO 3 R 21; X3 is N or C-R 14, wherein R 14 is hydrogen, halogen, -CN, alkyl, cycloalkyl, or alkoxy; X4 is N or C-R 15, wherein R 15 is hydrogen, halogen, -CN, alkyl, alkoxy, aryloxy, aralkyloxy, cycloalkylalkyloxy, heterocyclyloxy, heteroarylalkyloxy, or alkynyloxy; R 16 is hydrogen, halogen, -N COX, or -W-X, wherein W is a bond, -O-, -S-, or - NH-, and X is selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkynyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; each R 21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and each R 22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and provided that when X6 is N, then R 5 and R 6 are not hydrogen. R 2 is alkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl; X6 is C-H or N; X5 is C-R 5 or N; provided that if X6 is N, then X5 is C-R 5, and if X5 is N, then X6 is CH; R 5 is hydrogen, halogen, -OH, -CN, -OR 61, -NHR 61, -N(R 61) 2, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein each R 61 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R 6 is hydrogen, halogen, -OH, -CN, alkyl, cycloalkyl, cycloalkylalkyl, amino, alkylamino, dialkylamino, cycloalkylalkylamino, alkoxy, -S-alkyl, cycloalkylalkoxy, heterocyclyl, aralkoxy, heteroaryloxy, aryloxy, alkynyloxy, or -N COalkyl; R A is X2 is N or C-R 12, wherein R 12 is hydrogen, halogen, alkyl, or alkoxy; R 13 is -Y-Z; Y is selected from a bond, -CH 2 -, or -CH(C 1 -C 4 alkyl)-; Z is selected from -SO 2 R 21, -N(R 22)SO 2 R 21, -SO 2 N(R 22) 2, -N(R 22)SO 2 N(R 22) 2, - CON(R 22) 2, -N(R 22)CO 2 R 21, -N(R 22)CON(R 22) 2, -N(R 22)COR 21, -COR 21,-OC N(R 22) 2, -OSO 2 N(R 22) 2, or -N(R 22)SO 3 R 21; X3 is N or C-R 14, wherein R 14 is hydrogen, halogen, -CN, alkyl, cycloalkyl, or alkoxy; X4 is N or C-R 15, wherein R 15 is hydrogen, halogen, -CN, alkyl, alkoxy, aryloxy, aralkyloxy, cycloalkylalkyloxy, heterocyclyloxy, heteroarylalkyloxy, or alkynyloxy; R 16 is hydrogen, halogen, -N COX, or -W-X, wherein W is a bond, -O-, -S-, or - NH-, and X is selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkynyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; each R 21 is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and each R 22 is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and provided that when X6 is N, then R 5 and R 6 are not hydrogen.