A compound of general formula: in which R 1 represents C 2 -C 6 -hydroxyalkyl, wherein said C 2 -C 6 -hydroxyalkyl groups are optionally substituted once with cyano, -COOR 10, -CONR 11 R 12, C 1 -C 4 -alkoxy or C 3 -C 6 -cycloalkyl and optionally one to three times with halogen, or C 3 -C 6 -cycloalkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or (C 3 -C 6 -cycloalkyl) 2 -C 1 -C 3 -alkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or 4- to 6-membered heterocycloalkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen; R 2 represents chloro, cyano, dimethylamino, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy; R 3 represents hydrogen, fluoro, chloro or methyl; R 4 represents hydrogen or fluoro; R 5 represents monocyclic heteroaryl, which is optionally substituted one to three times, independently from each other, with R 6; R 6 represents C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, halogen or cyano; X represents CH or N; R 10 represents C 1 -C 4 -alkyl; R 11 and R 12 are the same or different and represent, independently from each other, hydrogen or C 1 -C 3 -alkyl, or together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, said ring optionally containing one additional heteroatom selected from O, S, NH, NR a in which R a represents a C 1 -C 4 -alkyl group; their polymorphs, enantiomeres, diastereomeres, racemates, tautomeres, N-oxides, hydrates and solvates, as well as their physiological acceptable salts and solvates of these salts, as well as mixtures of the same. R 1 represents C 2 -C 6 -hydroxyalkyl, wherein said C 2 -C 6 -hydroxyalkyl groups are optionally substituted once with cyano, -COOR 10, -CONR 11 R 12, C 1 -C 4 -alkoxy or C 3 -C 6 -cycloalkyl and optionally one to three times with halogen, or C 3 -C 6 -cycloalkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or (C 3 -C 6 -cycloalkyl) 2 -C 1 -C 3 -alkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen, or 4- to 6-membered heterocycloalkyl substituted once with hydroxy and optionally once with C 1 -C 3 -alkyl and/or one to three times with halogen; R 2 represents chloro, cyano, dimethylamino, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy; R 3 represents hydrogen, fluoro, chloro or methyl; R 4 represents hydrogen or fluoro; R 5 represents monocyclic heteroaryl, which is optionally substituted one to three times, independently from each other, with R 6; R 6 represents C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, halogen or cyano; X represents CH or N; R 10 represents C 1 -C 4 -alkyl; R 11 and R 12 are the same or different and represent, independently from each other, hydrogen or C 1 -C 3 -alkyl, or together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, said ring optionally containing one additional heteroatom selected from O, S, NH, NR a in which R a represents a C 1 -C 4 -alkyl group;