mhurhangee/ep-ind-claims huggingface dataset:
Display and operator control device of a motor vehicle comprising at least one display device, a touch-sensitive position detection unit coupled to the at least one display device and a control device coupled to the at least one display device and the position detection unit, which comprises an evaluation logic, which evaluates the touch positions detected by the position detection unit and by means of this influences the control of a representation of information on the at least one display device and a calling up of functions and/or control of systems that can be operated via the display and operator control device, wherein the evaluation logic is designed to evaluate the detected touch positions in a time-resolved manner, wherein the detected touch positions continuously merging into one another sequentially in time are combined to form a touch trace and the evaluation logic comprises at least one differentiating unit, which determines a velocity and/or an acceleration of a glancing actuation movement generating the touch trace, and the influencing of the control is different for differently determined velocities and/or accelerations, so that to increase a number of possible differentiable actuation actions in addition to a form of the detected touch positions continuously merging into one another sequentially in time combined into the touch trace also the velocity or the acceleration of the glancing actuation movement generating the touch trace determines the user input, and wherein the control device is designed to assign a mass and a coefficient of friction to objects (7, 7') represented on the display surface and the evaluation logic by means of a determined acceleration, with which the glancing actuation movement generating the touch trace is carried out, and at least of one direction of the touch trace and optionally of further properties of the touch trace and/or of the movement generating the touch trace determines a control impulse and an object (7, 7') in the display area or activation area of which the touch trace begins is moved on the display device according to a path curve calculated by means of the assigned mass and the assigned coefficient of friction and the determined control impulse, characterized in that at least one second further display surface designed separately from a display surface of the at least one display device is provided and the control device is designed to display an object (7, 7') on the further display surface, the path curve of which points beyond the display surface by a predetermined minimum length in a direction, in which the at least one further display surface is located.
A method of testing the ability of a CRISPR/Cas9 nuclease to modify a target genomic locus in vivo, comprising: (a) introducing into a non-human animal that is a mouse or rat a guide RNA designed to target a guide RNA target sequence at the target genomic locus, wherein the mouse or rat comprises a genomically integrated Cas9 expression cassette comprising a coding sequence for a Cas9 protein further comprising one or more nuclear localization signals, wherein the Cas9 expression cassette is integrated at a Rosa26 locus, and wherein the Cas9 expression cassette is integrated into the first intron of the Rosa26 locus, and wherein the guide RNA is introduced via adeno-associated virus -mediated delivery, wherein the AAV is an AAV8 delivered to the mouse or rat by intravenous injection; and (b) assessing the modification of the target genomic locus in the liver of the mouse or rat. (a) introducing into a non-human animal that is a mouse or rat a guide RNA designed to target a guide RNA target sequence at the target genomic locus, wherein the mouse or rat comprises a genomically integrated Cas9 expression cassette comprising a coding sequence for a Cas9 protein further comprising one or more nuclear localization signals, wherein the Cas9 expression cassette is integrated at a Rosa26 locus, and wherein the Cas9 expression cassette is integrated into the first intron of the Rosa26 locus, and wherein the guide RNA is introduced via adeno-associated virus -mediated delivery, wherein the AAV is an AAV8 delivered to the mouse or rat by intravenous injection; and wherein the mouse or rat comprises a genomically integrated Cas9 expression cassette comprising a coding sequence for a Cas9 protein further comprising one or more nuclear localization signals, wherein the Cas9 expression cassette is integrated at a Rosa26 locus, and wherein the Cas9 expression cassette is integrated into the first intron of the Rosa26 locus, and wherein the guide RNA is introduced via adeno-associated virus -mediated delivery, wherein the AAV is an AAV8 delivered to the mouse or rat by intravenous injection; and (b) assessing the modification of the target genomic locus in the liver of the mouse or rat.
A light guide comprising: a planar light conducting body comprising two opposite surfaces that are an input surface for receiving backlight illumination and an output surface for emitting received backlight illumination; the planar light conducting body comprising for each of a plurality of backlight illumination sources: an in-coupling structure aligned with one of the backlight illumination sources and configured to receive backlight illumination through the input surface and to laterally spread most of the received backlight within the planar light conducting body; an out-coupling structure configured to direct most of the laterally spread backlight through the output surface for the emitting of the received backlight illumination; the in-coupling structure comprising at least one intruding or protruding form on at least one of the input surface and the output surface; and the out-coupling structure comprising at least one intruding or protruding form on at least one of the input surface and the output surface; wherein the in-coupling structure comprises an in-coupling grating that comprises a form on the input surface configured to focus the received backlight illumination towards the output surface; and wherein the in-coupling structure is configured to laterally spread by reflecting with a spreading reflector the focused backlight within the planar light conducting body. a planar light conducting body comprising two opposite surfaces that are an input surface for receiving backlight illumination and an output surface for emitting received backlight illumination; the planar light conducting body comprising for each of a plurality of backlight illumination sources: an in-coupling structure aligned with one of the backlight illumination sources and configured to receive backlight illumination through the input surface and to laterally spread most of the received backlight within the planar light conducting body; an out-coupling structure configured to direct most of the laterally spread backlight through the output surface for the emitting of the received backlight illumination; an in-coupling structure aligned with one of the backlight illumination sources and configured to receive backlight illumination through the input surface and to laterally spread most of the received backlight within the planar light conducting body; an out-coupling structure configured to direct most of the laterally spread backlight through the output surface for the emitting of the received backlight illumination; the in-coupling structure comprising at least one intruding or protruding form on at least one of the input surface and the output surface; and the out-coupling structure comprising at least one intruding or protruding form on at least one of the input surface and the output surface; wherein the in-coupling structure comprises an in-coupling grating that comprises a form on the input surface configured to focus the received backlight illumination towards the output surface; and wherein the in-coupling structure is configured to laterally spread by reflecting with a spreading reflector the focused backlight within the planar light conducting body.
A respiratory assembly comprising: a base engaged with: at least one connector, wherein the base is in fluid communication with a hose or fluid source for allowing the gaseous flowthrough between the at least one connector, the base, and the hose or fluid source; a pair of sockets engaged with the at least one connector, wherein each socket defines: a collar; a cavity extending through the collar for receiving respective posts, characterized in that the collar has a first mode of operation in which a post is engaged with the collar and a second mode of operation in which the post is not engaged with the collar through retraction of a locking member (130 or 132) in response to manipulation by a user, wherein the posts are configured for sealably engaging a patient's nare, wherein the respiratory assembly is maskless and strapless. at least one connector, wherein the base is in fluid communication with a hose or fluid source for allowing the gaseous flowthrough between the at least one connector, the base, and the hose or fluid source; a pair of sockets engaged with the at least one connector, wherein each socket defines: a collar; a cavity extending through the collar for receiving respective posts, characterized in that the collar has a first mode of operation in which a post is engaged with the collar and a second mode of operation in which the post is not engaged with the collar through retraction of a locking member (130 or 132) in response to manipulation by a user, a collar; a cavity extending through the collar for receiving respective posts, characterized in that the collar has a first mode of operation in which a post is engaged with the collar and a second mode of operation in which the post is not engaged with the collar through retraction of a locking member (130 or 132) in response to manipulation by a user, wherein the posts are configured for sealably engaging a patient's nare, wherein the respiratory assembly is maskless and strapless.
A portable cleaner comprising: a recovery tank including a container for receiving and storing recovered liquid and/or dirt and an openable tank lid for covering the container, the container and the tank lid removable from the cleaner as a unit; a main housing configured to removably support the recovery tank in a vertical orientation in which the tank lid at least partially defines a top side of the portable extraction cleaner; and a tank latch provided in the tank lid, the tank latch configured to selectively secure and release the tank lid to the main housing when the recovery tank is supported by the main housing. a recovery tank including a container for receiving and storing recovered liquid and/or dirt and an openable tank lid for covering the container, the container and the tank lid removable from the cleaner as a unit; a main housing configured to removably support the recovery tank in a vertical orientation in which the tank lid at least partially defines a top side of the portable extraction cleaner; and a tank latch provided in the tank lid, the tank latch configured to selectively secure and release the tank lid to the main housing when the recovery tank is supported by the main housing.
An apparatus for treating uterine disorders by effecting necrosis of a uterine endometrium, the apparatus comprising: • a catheter having a proximal end and a distal end; • a bladder attached to the proximal end for insertion into uterus and being distendable upon introduction of an inflation medium; • a reservoir containing the inflation medium; • heating means configured to heat the inflation medium to a necrosis temperature; and • inflation means (12, 13) being operative for moving the inflation medium between the reservoir and the bladder; wherein the apparatus further comprises a removable occlusion member (5, 43) arranged between the reservoir and the bladder to prevent flow of the inflation medium from the reservoir to the bladder, characterized in that the occlusion member (5, 43) is configured to be automatically removed at a specific temperature of the inflation medium, and wherein the occlusion member (5, 43) is in thermal communication with the inflation medium and configured to be triggered by the temperature thereof. • a catheter having a proximal end and a distal end; • a bladder attached to the proximal end for insertion into uterus and being distendable upon introduction of an inflation medium; • a reservoir containing the inflation medium; • heating means configured to heat the inflation medium to a necrosis temperature; and • inflation means (12, 13) being operative for moving the inflation medium between the reservoir and the bladder;
Method for producing a threaded borehole in a workpiece with a tapping tool, which on its drill bit has a main cutting edge and a thread profile lagging in a tapping direction, wherein the method has a tapping stroke, in which the tapping tool is driven with a tapping feed (f G) in the tapping direction and with a tapping speed (n G) synchronised therewith into the workpiece and the tool main cutting edge produces a core borehole and the tool thread profile forms an internal thread on the inner wall of the core borehole, and has a reversing stroke, in which the tapping tool is guided in a reversing direction out of the threaded borehole with opposite reversing stroke (f R) and reversing speed (n R) synchronised therewith, so that the tool thread profile in the thread turn of the internal thread is guided out of the threaded borehole, wherein in the tapping stroke chips are produced, which are extracted in a chip removal direction in the opposite direction to the tapping direction out of the threaded borehole and thereby collide with the thread flanks of the internal thread facing the chips to be removed, characterised in that in the tapping stroke the thread flanks of the internal thread facing the chips are not yet produced to finished size, but rather are produced with a flank allowance (Δx), specifically forming a collision contour, with which chips to be removed collide.
A telescopic arm for an operating machine, of the type including a plurality of coaxial extensible sliding elements, wherein the telescopic arm is constrained, in the region of its own base end, to a platform, associated to said operating machine, by means of a outer base element, hinged to said platform; said extensible sliding elements being arranged telescopically in coaxial relationship and having a cross-section decreasing from the first to the last element, the free end of this last element being provided with an operating head with a hydraulic supply; the extensible sliding elements of said plurality being designed to switch, upon command, between two extreme configurations: a closed configuration, in which they are at least partially inserted into one another to define a minimum overall length of the telescopic arm, and an open configuration, in which they are mutually positioned in such a way to define a maximum overall length of the telescopic arm; the telescopic arm including: a synchronous driving system, for length extension and retraction of said extensible sliding elements, which is partially supported outside of the same telescopic arm; a hydraulic circuit, mainly housed within said telescopic arm and consisting of hydraulic conduits which include fixed pipes and hoses, respectively, which are kept stretched, during the extension and retraction motion of said extensible sliding elements, by corresponding idle pulleys supported by the latter, said plurality comprising, at least one coaxial extensible sliding base element, which is coupled to the outer base element and to which a first said extensible sliding element is coupled, wherein these elements can be extracted consecutively from one another in the axial direction; with a second extensible sliding element, a third extensible sliding element and a fourth extensible sliding element coupled in succession to said first extensible sliding element; there being provided a first hydraulic actuator, placed outside the telescopic arm and operating between the outer base element and the coaxial extensible sliding base element, and a second hydraulic actuator operating between the coaxial extensible sliding base element and the first extensible sliding element; characterized in that the second hydraulic actuator, operating between the coaxial extensible sliding base element and the first extensible sliding element, is arranged outside with respect to the telescopic arm and has an end of its stem secured to the extensible sliding arm, and has its cylinder firmly attached, in the region of its own fore end, to the coaxial extensible sliding base element and its bottom side end free to overlap, at least partially, the outer surface of the outer base element and to slide with respect to it, in a direction parallel to the axis of the telescopic arm.
A pyridine amide derivative of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are indipendently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula or, wherein B is C OH, C O(C1-C3)alkyl, and C is selected from the group consisting of: m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C -; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N,O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. R 1 and R 2 are indipendently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula or, wherein B is C OH, C O(C1-C3)alkyl, and C is selected from the group consisting of: m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C -; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N,O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl.
Low drop-out voltage regulator operable to compensate a zero frequency with respect to a variable load at an output of the voltage regulator in order to provide a stable output (Vreg) taking into account any temperature variation, said voltage regulator comprising: - a regulation loop comprising at least a pass transistor, a source transistor, a sensing transistor and a retention transistor, for which sources of the pass transistor and the source transistor are connected to a first node, a drain of the source transistor is connected to a drain of the retention transistor and to a gate of the pass transistor to form a second node, a drain of the pass transistor is connected to a source of the sensing transistor at an output node, and a source of the retention transistor is connected to a drain of the sensing transistor, characterized in that the voltage regulator comprises a stability compensation circuit comprising a first MOS resistor, which is a stable resistor, and a second MOS resistor, which is a variable resistor, coupled with the first MOS resistor, and at least one capacitor coupled by a first terminal with a drain of at least one of the first MOS resistor and the second MOS resistor, in that a second terminal of the capacitor is connected to the second node coupled with a drain of the retention transistor and with a drain of the source transistor, in that the gate of the second MOS resistor is coupled to the gate of the pass transistor at the second node, and in that the gate of the first MOS resistor is coupled to a gate of the source transistor. - a regulation loop comprising at least a pass transistor, a source transistor, a sensing transistor and a retention transistor, for which sources of the pass transistor and the source transistor are connected to a first node, a drain of the source transistor is connected to a drain of the retention transistor and to a gate of the pass transistor to form a second node, a drain of the pass transistor is connected to a source of the sensing transistor at an output node, and a source of the retention transistor is connected to a drain of the sensing transistor,
Process for producing a polyacrylonitrile-sulphur composite material comprising the process steps of: a) reacting polyacrylonitrile to afford cyclized polyacrylonitrile, b) reacting the cyclized polyacrylonitrile with sulphur to afford a polyacrylonitrile-sulphur composite material. a) reacting polyacrylonitrile to afford cyclized polyacrylonitrile, b) reacting the cyclized polyacrylonitrile with sulphur to afford a polyacrylonitrile-sulphur composite material.
A high strength steel plate having yield strength of 448 MPa or higher, consisting of 0.02 to 0.08 % C, 0.01 to 0.5 % Si, 0.5 to 1.5 % Mn, 0.01 % or less P, 0.002 % or less S, 0.07 % or less Al, by mass, at least two elements selected from the group consisting of 0.005 to 0.04 % Ti, 0.005 to 0.05 % Nb, and 0.005 to 0.1 % V, optionally from 0.0005 to 0.005 % Ca, by mass and further optionally containing at least one element selected from 0.5 % or less Cu, 0.5 % orless Ni and 0.5 % or less Cr, balance Fe, and with [C/(Ti + Nb + V)] as ratio of C content to the sum of Ti, Nb, and V contents by atom percentage being 0.5 to 3, and having substantially a two phase microstructure of ferrite and bainite, the ferrite containing precipitates of complex carbides having particle size of 30 nm or smaller and the bainite having area percentage of 10 to 80 %.
Fuel cell system comprising at least one fuel cell stack having an anode section and a cathode section, an ejector, a fuel mixture conduit for conducting a fuel mixture comprising primary fuel and secondary fuel from the ejector to the anode section, a primary fuel line for supplying the primary fuel to the ejector, and a recirculation line for recirculating the secondary fuel from the anode section to the ejector, characterised in that the primary fuel line extends at least in sections through a heat exchange volume within the recirculation line for a heat-transferring connection between the secondary fuel and the primary fuel, wherein the ejector has a nozzle and the primary fuel line extends within the heat exchange volume as far as the nozzle.