A surgical instrument assembly configured to be attached to and detached from a surgical robot, wherein said surgical instrument assembly comprises: a housing assembly configured to be attached to said surgical robot; a transmission assembly mounted to the housing assembly; a firing system; a closure system; a shaft assembly attachable to the transmission assembly, comprising: a shaft; and an end effector, comprising: a first jaw; and a second jaw, wherein the second jaw is rotatable relative to the first jaw between an open, unclamped configuration and a closed, clamped configuration, wherein said closure system is configured to be actuated by the surgical robot to selectively place said end effector into said clamped configuration and said unclamped configuration when said surgical instrument assembly is operably attached to the surgical robot; and a manually-actuatable bailout configured to actuate said closure system to manually place said end effector into said clamped configuration and said unclamped configuration when said surgical instrument assembly is detached from the surgical robot, wherein said shaft comprises a spine, wherein said closure system comprises a closure tube (3120, 4120), wherein said closure tube is configured to be actuated in a first direction to place said end effector into said clamped configuration and in a second direction to place said end effector into said unclamped configuration, and wherein said first direction is opposite said second direction, wherein at least one of said housing assembly and said transmission assembly is configured to receive, when said surgical instrument assembly is operably attached to said surgical robot, rotary and/or linear inputs from said surgical robot into the housing assembly and/or transmission assembly to operate said shaft assembly. a housing assembly configured to be attached to said surgical robot; a transmission assembly mounted to the housing assembly; a firing system; a closure system; a shaft; and an end effector, comprising: a first jaw; and a second jaw, wherein the second jaw is rotatable relative to the first jaw between an open, unclamped configuration and a closed, clamped configuration, wherein said closure system is configured to be actuated by the surgical robot to selectively place said end effector into said clamped configuration and said unclamped configuration when said surgical instrument assembly is operably attached to the surgical robot; and a first jaw; and a second jaw, wherein the second jaw is rotatable relative to the first jaw between an open, unclamped configuration and a closed, clamped configuration, wherein said closure system is configured to be actuated by the surgical robot to selectively place said end effector into said clamped configuration and said unclamped configuration when said surgical instrument assembly is operably attached to the surgical robot; and a manually-actuatable bailout configured to actuate said closure system to manually place said end effector into said clamped configuration and said unclamped configuration when said surgical instrument assembly is detached from the surgical robot, wherein said shaft comprises a spine, wherein said closure system comprises a closure tube (3120, 4120), wherein said closure tube is configured to be actuated in a first direction to place said end effector into said clamped configuration and in a second direction to place said end effector into said unclamped configuration, and wherein said first direction is opposite said second direction, wherein at least one of said housing assembly and said transmission assembly is configured to receive, when said surgical instrument assembly is operably attached to said surgical robot, rotary and/or linear inputs from said surgical robot into the housing assembly and/or transmission assembly to operate said shaft assembly.