A method of evaluating cellular activity, said method comprising: (a) placing a cell population on an area; (b) assaying for a dynamic behavior of the cell population as a function of time, wherein the dynamic behavior is selected from the group consisting of cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, metabolite secretion, changes in lipid profiles, microvesicle secretion, exosome secretion, microparticle secretion, changes in cellular mass, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, cell membrane polarization, establishment of a synapse, dynamic trafficking of proteins, granule polarization, calcium activation, metabolic changes, small molecule secretion, proton secretion, and combinations thereof, and wherein the assaying occurs at a single-cell level; (c) identifying one or more cells of interest based on the dynamic behavior; (d) characterizing a molecular profile of the one or more identified cells the characterized molecular profile of the one or more identified cells is selected from the group consisting of transcription activity, transcriptomic profile, gene expression activity, genomic profile, protein expression activity, proteomic profile, protein interaction activity, cellular receptor expression activity, lipid profile, lipid activity, carbohydrate profile, microvesicle activity, glucose activity, metabolic profile, and combinations thereof, and wherein the characterizing occurs at a single-cell level; and (e) correlating the information obtained from steps (b) and (d) wherein the correlating comprises integrating the assayed dynamic behavior and the characterized molecular profile, and wherein the correlating occurs at a single-cell level. (a) placing a cell population on an area; (b) assaying for a dynamic behavior of the cell population as a function of time, wherein the dynamic behavior is selected from the group consisting of cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, metabolite secretion, changes in lipid profiles, microvesicle secretion, exosome secretion, microparticle secretion, changes in cellular mass, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, cell membrane polarization, establishment of a synapse, dynamic trafficking of proteins, granule polarization, calcium activation, metabolic changes, small molecule secretion, proton secretion, and combinations thereof, and wherein the assaying occurs at a single-cell level; (c) identifying one or more cells of interest based on the dynamic behavior; (d) characterizing a molecular profile of the one or more identified cells the characterized molecular profile of the one or more identified cells is selected from the group consisting of transcription activity, transcriptomic profile, gene expression activity, genomic profile, protein expression activity, proteomic profile, protein interaction activity, cellular receptor expression activity, lipid profile, lipid activity, carbohydrate profile, microvesicle activity, glucose activity, metabolic profile, and combinations thereof, and wherein the characterizing occurs at a single-cell level; and the characterized molecular profile of the one or more identified cells is selected from the group consisting of transcription activity, transcriptomic profile, gene expression activity, genomic profile, protein expression activity, proteomic profile, protein interaction activity, cellular receptor expression activity, lipid profile, lipid activity, carbohydrate profile, microvesicle activity, glucose activity, metabolic profile, and combinations thereof, and wherein the characterizing occurs at a single-cell level; and (e) correlating the information obtained from steps (b) and (d) wherein the correlating comprises integrating the assayed dynamic behavior and the characterized molecular profile, and wherein the correlating occurs at a single-cell level.