A sole structure for an article of footwear having an upper, the sole structure including a midsole attachable to the upper and an outsole extending between the midsole and a ground surface, the sole structure comprising: a heel region; a forefoot region including a toe portion; a mid-foot region disposed between the heel region and the forefoot region; the midsole including: a first chamber extending from the mid-foot region to the toe portion of the forefoot region and including a plurality of segments (218a-218d) that extend from a lateral side to a medial side of the midsole, wherein the plurality of segments (218a-218d) comprises: (i) a first segment having a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole, a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole; and (ii) a second segment having a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole, a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole. a heel region; a forefoot region including a toe portion; a mid-foot region disposed between the heel region and the forefoot region; the midsole including: a first chamber extending from the mid-foot region to the toe portion of the forefoot region and including a plurality of segments (218a-218d) that extend from a lateral side to a medial side of the midsole, wherein the plurality of segments (218a-218d) comprises: (i) a first segment having a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole, a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole; and (ii) a second segment having a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole, a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole. (i) a first segment having a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole, a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole; and (ii) a second segment having a lateral reservoir defining a prolate hemispheroid shape including a major axis extending along the lateral side of the midsole, a medial reservoir defining a prolate hemispheroid shape including a major axis extending along the medial side of the midsole and a central reservoir defining a prolate hemispheroid having a major axis extending transverse to each of the medial side and the lateral side of the midsole.