A compound of formula or a pharmaceutically acceptable salt, hydrate, or solvate thereof wherein: R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy, -NR 3 R 4 or -N(OR 3)R 4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy and benzyloxy are unsubstituted or substituted with one or more substituents; R 3 and R 4 are independently alkyl, heterocycloalkyl or aryl, wherein said alkyl, heterocycloalkyl and aryl are unsubstituted or substituted with one or more substituents; L is SO 2, Y is aryl and said aryl is unsubstituted or substituted with one or more substituents independently selected from W, and W is halo, -OH, -CN, -NO 2, -COR 1, -COOR 1, -CONR 1 R 2, -CH(C R 1) 2, -SO 2 R 1, or -COX, wherein X is halo and R 1 and R 2 are independently alkyl or aryl, or R 1 and R 2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents; and where the substituents which may be present when the above groups include said one or more substituents are the same or different and are selected from halo, hydroxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, cyano, nitro, mercapto, oxo, carbonyl, thio, imino, formyl, carbamido, carbamyl, carboxyl, thioureido, thiocyanato, sulfoamido, sulfonylalkyl, sulfonylaryl, alkyl, alkenyl, alkoxy, mercaptoalkoxy, aryl, heteroaryl, cyclyl, heterocyclyl, wherein alkyl, alkenyl, alkyloxy, aryl, heteroaryl, cyclyl, and heterocyclyl are optionally substituted with alkyl, aryl, heteroaryl, halogen, hydroxyl, amino, mercapto, cyano, nitro, oxo, thioxo, or imino; said compound, salt, hydrate, or solvate being for use in a method of treating a disease or condition selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease and pulmonary hypertension. R is hydrogen, alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy, benzyloxy, -NR 3 R 4 or -N(OR 3)R 4, wherein said alkyl, heterocycloalkyl, aryl, benzyl, alkoxy, heterocycloalkoxy, aryloxy and benzyloxy are unsubstituted or substituted with one or more substituents; R 3 and R 4 are independently alkyl, heterocycloalkyl or aryl, wherein said alkyl, heterocycloalkyl and aryl are unsubstituted or substituted with one or more substituents; L is SO 2, Y is aryl and said aryl is unsubstituted or substituted with one or more substituents independently selected from W, and W is halo, -OH, -CN, -NO 2, -COR 1, -COOR 1, -CONR 1 R 2, -CH(C R 1) 2, -SO 2 R 1, or -COX, wherein X is halo and R 1 and R 2 are independently alkyl or aryl, or R 1 and R 2 are taken together to form a cycloalkyl or heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more substituents; and where the substituents which may be present when the above groups include said one or more substituents are the same or different and are selected from halo, hydroxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, cyano, nitro, mercapto, oxo, carbonyl, thio, imino, formyl, carbamido, carbamyl, carboxyl, thioureido, thiocyanato, sulfoamido, sulfonylalkyl, sulfonylaryl, alkyl, alkenyl, alkoxy, mercaptoalkoxy, aryl, heteroaryl, cyclyl, heterocyclyl, wherein alkyl, alkenyl, alkyloxy, aryl, heteroaryl, cyclyl, and heterocyclyl are optionally substituted with alkyl, aryl, heteroaryl, halogen, hydroxyl, amino, mercapto, cyano, nitro, oxo, thioxo, or imino; said compound, salt, hydrate, or solvate being for use in a method of treating a disease or condition selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease and pulmonary hypertension.