A multi-cannula surgical instrument, comprising - a rigid outer cannula comprising a proximal end and a sharp distal tip, sized to pierce tissue forming a wall of an anatomical cavity or structure; - an inner cannula comprising • a proximal end and a blunt distal tip arranged to hamper penetration of tissue and / or to prevent involuntary damage of tissue by said blunt distal tip, • one or more first inner ducts and one or more first flow-through orifices near said blunt distal tip, said one or more first flow-through orifices being in fluid communication with said first inner duct(s), said first inner duct(s) and said first flow-through orifice(s) being configured to allow one or more fluid flows therethrough; wherein said outer cannula at least partially surrounds said inner cannula and said inner cannula is movably disposed within said outer cannula between a retracted position, wherein said distal tip of said outer cannula is positioned beyond said blunt distal tip concealing said blunt distal tip, and an advanced position, wherein said blunt distal tip is positioned beyond said distal tip of said outer cannula concealing said distal tip of said outer cannula; - a hub mounting said inner and said outer cannula (2, 3) at said proximal ends (2a, 3a) of said inner and said outer cannula (2, 3), said hub comprising a biasing mechanism being coupled to said inner cannula and being arranged to bias said inner cannula automatically from said retracted towards said advanced position in case of absence of resistance against said inner cannula, CHARACTERISED IN THAT said outer cannula comprises one or more second flow-through orifices at said distal tip thereof, and said multi-cannula surgical instrument comprises one or more second ducts arranged between said inner cannula and said outer cannula, said second duct(s) being in fluid communication with said one or more second flow-through orifices and said second duct(s), said one or more second flow-through orifices and said hub being configured to allow at least one fluid flow throughout said hub, said second duct(s) and said one or more second flow-through orifices. - a rigid outer cannula comprising a proximal end and a sharp distal tip, sized to pierce tissue forming a wall of an anatomical cavity or structure; - an inner cannula comprising • a proximal end and a blunt distal tip arranged to hamper penetration of tissue and / or to prevent involuntary damage of tissue by said blunt distal tip, • one or more first inner ducts and one or more first flow-through orifices near said blunt distal tip, said one or more first flow-through orifices being in fluid communication with said first inner duct(s), said first inner duct(s) and said first flow-through orifice(s) being configured to allow one or more fluid flows therethrough; • a proximal end and a blunt distal tip arranged to hamper penetration of tissue and / or to prevent involuntary damage of tissue by said blunt distal tip, • one or more first inner ducts and one or more first flow-through orifices near said blunt distal tip, said one or more first flow-through orifices being in fluid communication with said first inner duct(s), said first inner duct(s) and said first flow-through orifice(s) being configured to allow one or more fluid flows therethrough; - a hub mounting said inner and said outer cannula (2, 3) at said proximal ends (2a, 3a) of said inner and said outer cannula (2, 3), said hub comprising a biasing mechanism being coupled to said inner cannula and being arranged to bias said inner cannula automatically from said retracted towards said advanced position in case of absence of resistance against said inner cannula,