A compound selected from the group consisting of 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(2-hydroxy-2-methylpropyl)acetamide; 2-(( 1r, 4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1 -yl)cyclohexyl)acetonitrile; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(cyclopropylmethyl)acetamide; N -(2-Cyanoethyl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(tetrahydro-2H-pyran-4-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((tetrahydro-2 H -pyran-4-yl)methyl)acetamide; N -(2-Cyano-2-methylpropyl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((1-hydroxycyclobutyl)methyl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N- (1-methyl-1 H- pyrazol-4-yl)acetamide; N -(4-(Cyanomethyl)bicyclo[2.2.1]heptan-1-yl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N- (1 H- pyrazol-3-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((1-hydroxycyclopropyl)methyl)acetamide; and pharmaceutically acceptable salts, and combinations thereof. 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(2-hydroxy-2-methylpropyl)acetamide; 2-(( 1r, 4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1 -yl)cyclohexyl)acetonitrile; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(cyclopropylmethyl)acetamide; N -(2-Cyanoethyl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)- N -(tetrahydro-2H-pyran-4-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((tetrahydro-2 H -pyran-4-yl)methyl)acetamide; N -(2-Cyano-2-methylpropyl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((1-hydroxycyclobutyl)methyl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N- (1-methyl-1 H- pyrazol-4-yl)acetamide; N -(4-(Cyanomethyl)bicyclo[2.2.1]heptan-1-yl)-2-(1-(( 1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N- (1 H- pyrazol-3-yl)acetamide; 2-(1-(( 1r, 4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-2-yl)- N -((1-hydroxycyclopropyl)methyl)acetamide; and pharmaceutically acceptable salts, and combinations thereof.