A fluid handling system, the system comprising: a console housing comprising: one or more pumps; a controller configured to operate the pump(s); and a catheter assembly comprising: a catheter body having a proximal portion and an operative device at a distal portion; and an infusion system in fluid communication with the proximal portion of the catheter body, the infusion system comprising an interface member configured to be separate from the console housing in a first state and to at least partially secure the infusion system to the console housing in a second state, wherein upon engagement of the interface member with the console housing in the second state, the infusion system is operably engaged with the pump(s), wherein first and second occlusion beds (322a, 322b) are formed in the interface member, the first occlusion bed including a first arcuate recessed region formed in the interface member and the second occlusion bed including a second arcuate recessed region formed in the interface member, the interface member further including first and second pump tube segments (324a, 324b) positioned along the occlusion beds (322a, 322b) formed in the interface member, and wherein, in the second state, upon engagement of the interface member with the console housing, the one or more pumps engage with the interface member and compress the first and second pump tube segments (324a, 324b) against the first and second occlusion beds (322a, 322b), respectively. a console housing comprising: one or more pumps; a controller configured to operate the pump(s); and one or more pumps; a controller configured to operate the pump(s); and a catheter assembly comprising: a catheter body having a proximal portion and an operative device at a distal portion; and an infusion system in fluid communication with the proximal portion of the catheter body, the infusion system comprising an interface member configured to be separate from the console housing in a first state and to at least partially secure the infusion system to the console housing in a second state, wherein upon engagement of the interface member with the console housing in the second state, the infusion system is operably engaged with the pump(s), a catheter body having a proximal portion and an operative device at a distal portion; and an infusion system in fluid communication with the proximal portion of the catheter body, the infusion system comprising an interface member configured to be separate from the console housing in a first state and to at least partially secure the infusion system to the console housing in a second state, wherein upon engagement of the interface member with the console housing in the second state, the infusion system is operably engaged with the pump(s), wherein first and second occlusion beds (322a, 322b) are formed in the interface member, the first occlusion bed including a first arcuate recessed region formed in the interface member and the second occlusion bed including a second arcuate recessed region formed in the interface member, the interface member further including first and second pump tube segments (324a, 324b) positioned along the occlusion beds (322a, 322b) formed in the interface member, and wherein, in the second state, upon engagement of the interface member with the console housing, the one or more pumps engage with the interface member and compress the first and second pump tube segments (324a, 324b) against the first and second occlusion beds (322a, 322b), respectively.