An electro-hydraulic motor vehicle brake system, comprising: a first cylinder-piston device (110, 112, 114), which can be fluidically coupled to at least one wheel brake of the brake system, for generating hydraulic pressure on the at least one wheel brake, wherein the first cylinder-piston device (110, 112, 114) comprises at least one first piston (112, 114); a second cylinder-piston device (260, 262), which comprises at least one second piston; an electromechanical actuator acting on the second piston of the second cylinder-piston device (260, 262); wherein the second cylinder-piston device (260, 262) is or can be fluidically coupled at an output side to the at least one first piston (112, 114) of the first cylinder-piston device (110, 112, 114) in order to provide hydraulic pressure, which is generated in the second cylinder-piston device (260, 262) upon actuation of the electromechanical actuator, for actuating the at least one first piston (112, 114) of the first cylinder-piston device (110, 112, 114); and a pedal interface, which can be coupled to a brake pedal, with a third cylinder-piston device (120, 122), comprising a hydraulic chamber and being coupled to a simulator circuit, which can be selectively fluidically coupled to the first cylinder-piston device (110, 112, 114) for generating hydraulic pressure; wherein the third cylinder-piston-device (120, 122) comprises a hydraulic cylinder with a piston, being displaceably received therein and connected to the brake pedal, wherein the hydraulic cylinder and the side of the piston facing away from the brake pedal define the hydraulic chamber, which is fluidically coupled to the simulator circuit via a fluid path, wherein the simulator circuit comprises a hydraulic pressure store which is realised as a piston-cylinder arrangement, wherein the piston which is displaceably received in the cylinder is pre-tensioned by a spring; and wherein the first cylinder-piston device (110, 112, 114) has at least two hydraulic chambers (111, 116, 118) defined by a cylinder and the at least one first piston (112, 114), wherein the first chamber is fluidically coupled at the inlet side to the second cylinder-piston device (260, 262), and wherein at least one second chamber (116, 118) can be fluidically coupled to at least one brake circuit (10, 20) of the brake system; characterized in that the third cylinder-piston device (120, 122) can be fluidically coupled to the second cylinder-piston device (260, 262) by way of the first chamber of the first cylinder-piston device (110, 112, 114). a first cylinder-piston device (110, 112, 114), which can be fluidically coupled to at least one wheel brake of the brake system, for generating hydraulic pressure on the at least one wheel brake, wherein the first cylinder-piston device (110, 112, 114) comprises at least one first piston (112, 114); a second cylinder-piston device (260, 262), which comprises at least one second piston; an electromechanical actuator acting on the second piston of the second cylinder-piston device (260, 262); wherein the second cylinder-piston device (260, 262) is or can be fluidically coupled at an output side to the at least one first piston (112, 114) of the first cylinder-piston device (110, 112, 114) in order to provide hydraulic pressure, which is generated in the second cylinder-piston device (260, 262) upon actuation of the electromechanical actuator, for actuating the at least one first piston (112, 114) of the first cylinder-piston device (110, 112, 114); and a pedal interface, which can be coupled to a brake pedal, with a third cylinder-piston device (120, 122), comprising a hydraulic chamber and being coupled to a simulator circuit, which can be selectively fluidically coupled to the first cylinder-piston device (110, 112, 114) for generating hydraulic pressure; wherein the third cylinder-piston-device (120, 122) comprises a hydraulic cylinder with a piston, being displaceably received therein and connected to the brake pedal, wherein the hydraulic cylinder and the side of the piston facing away from the brake pedal define the hydraulic chamber, which is fluidically coupled to the simulator circuit via a fluid path, wherein the simulator circuit comprises a hydraulic pressure store which is realised as a piston-cylinder arrangement, wherein the piston which is displaceably received in the cylinder is pre-tensioned by a spring; and wherein the first cylinder-piston device (110, 112, 114) has at least two hydraulic chambers (111, 116, 118) defined by a cylinder and the at least one first piston (112, 114), wherein the first chamber is fluidically coupled at the inlet side to the second cylinder-piston device (260, 262), and wherein at least one second chamber (116, 118) can be fluidically coupled to at least one brake circuit (10, 20) of the brake system; characterized in that the third cylinder-piston device (120, 122) can be fluidically coupled to the second cylinder-piston device (260, 262) by way of the first chamber of the first cylinder-piston device (110, 112, 114).