mhurhangee/ep-ind-claims huggingface dataset:
Individualized cancer vaccine, obtainable by a method comprising (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing an individualized cancer vaccine featuring the cancer mutation signature obtained in step (a), wherein the individualized cancer vaccine is an RNA vaccine comprising RNA encoding a recombinant polyepitopic polypeptide comprising 5 or more neo-epitopes, for use in a method of preventing or treating cancer in a patient, said method comprising the steps of: (i) inducing a first immune response against one or more shared tumor antigens in the patient by administering a vaccine comprising (ia) one or more peptides or polypeptides each peptide or polypeptide comprising one or more shared tumor antigens expressed in cancer cells of the patient, (ib) one or more peptides or polypeptides each peptide or polypeptide comprising one or more T cell epitopes of one or more shared tumor antigens expressed in cancer cells of the patient or (ic) nucleic acid encoding the one or more peptides or polypeptides of (ia) or (ib), wherein the shared tumor antigens are tumor antigens shared by at least 60% of different patients having the same cancer type and/or different cancer types, and (ii) inducing a second immune response against one or more tumor antigens in the patient, wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient, and wherein the second immune response is induced by administering the individualized cancer vaccine. (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing an individualized cancer vaccine featuring the cancer mutation signature obtained in step (a), wherein the individualized cancer vaccine is an RNA vaccine comprising RNA encoding a recombinant polyepitopic polypeptide comprising 5 or more neo-epitopes, (i) inducing a first immune response against one or more shared tumor antigens in the patient by administering a vaccine comprising (ia) one or more peptides or polypeptides each peptide or polypeptide comprising one or more shared tumor antigens expressed in cancer cells of the patient, (ib) one or more peptides or polypeptides each peptide or polypeptide comprising one or more T cell epitopes of one or more shared tumor antigens expressed in cancer cells of the patient or (ic) nucleic acid encoding the one or more peptides or polypeptides of (ia) or (ib), wherein the shared tumor antigens are tumor antigens shared by at least 60% of different patients having the same cancer type and/or different cancer types, and (ii) inducing a second immune response against one or more tumor antigens in the patient, wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient, and wherein the second immune response is induced by administering the individualized cancer vaccine.
Fuel distributor, in particular for fuel injection systems of mixture-compressing, applied-ignition internal combustion engines, having a distribution body in which a fuel chamber is formed, and at least one support element, wherein at least one cup, on which the support element is arranged, is provided on the distribution body, and wherein the support element forms, at least in part, a support surface on an end of the cup, characterized in that the support element has a planar support ring which bears against the end of the cup, wherein the support ring has emanating therefrom a plurality of retaining arms (23, 24, 25, 26) which are provided with flexurally elastic arcuate portions (28, 29, 30) and are bent towards a circumferential outer side of the cup, with the result that fixing of the support element to the outer side of the cup is enabled by means of the retaining arms (23, 24, 25, 26).
Shaft of a dental tool which can be clamped into a driving device, having a distal end area, a cylindrical shaft area adjoining the distal end area as well as a proximal end area located opposite the distal end area, characterized in that the proximal end area is provided with a polygonal profile which tapers off conically in the direction towards the distal end area), which adjoins a tool part and through which a torque can be introduced into the shaft.
Wire cutting apparatus for separating parts from a base plate, comprising: - a wire electrode, configured to separate at least one part from a base plate from which the at least one part protrudes; - a holding device, configured to hold the base plate in at least a separation position relative to the separation device, wherein - the holding device is configured to hold the base plate in the separation position in such a manner, that the at least one part protrudes downward from the base plate, - a collecting element, which is arrangeable underneath the holding device and configured to receive the at least one part, when the at least one part is separated from the base plate by the separation device; characterized in that - the wire cutting apparatus is a fast-wire cutting machine including a wire travelling circuit, which is constituted such that the wire travels back and forth at high speed along the wire travelling direction; - in that the wire electrode is submerged in a separation liquid and the material is removed by a succession of electrical discharge between the wire electrode and the workpiece; and in that - the collecting element comprises at least one segregation element, arranged inside the collecting element and configured to segregate a) at least two distinct groups of the at least one part, and/or b) at least two distinct parts of the at least one part from each other - wherein the segregation element is configured as a wall or a plurality of walls, defining at least one recess adapted to receive a part separated from the base plate. - a wire electrode, configured to separate at least one part from a base plate from which the at least one part protrudes; - a holding device, configured to hold the base plate in at least a separation position relative to the separation device, wherein - the holding device is configured to hold the base plate in the separation position in such a manner, that the at least one part protrudes downward from the base plate, - a collecting element, which is arrangeable underneath the holding device and configured to receive the at least one part, when the at least one part is separated from the base plate by the separation device; - the wire cutting apparatus is a fast-wire cutting machine including a wire travelling circuit, which is constituted such that the wire travels back and forth at high speed along the wire travelling direction; - in that the wire electrode is submerged in a separation liquid and the material is removed by a succession of electrical discharge between the wire electrode and the workpiece; and in that - the collecting element comprises at least one segregation element, arranged inside the collecting element and configured to segregate a) at least two distinct groups of the at least one part, and/or b) at least two distinct parts of the at least one part from each other a) at least two distinct groups of the at least one part, and/or b) at least two distinct parts of the at least one part from each other - wherein the segregation element is configured as a wall or a plurality of walls, defining at least one recess adapted to receive a part separated from the base plate.
PVC-free tube comprising three layers (101, 102, 103) arranged one above another, wherein each of these layers contains a polyolefin, wherein a middle layer contains at least 60% of a thermoplastic elastomer selected from the group consisting of SEBS, SBS, SEPS, SEB, SIS and mixtures thereof, the loss factor thereof as a function of the temperature has a maximum at a temperature of above -30°C according to the method ISO 6721-7, characterized in that the polypropylene content in the inner layer is larger than in the outer layer and in that the layer thickness of the outer layer is 40-250 μm.
Cylinder for a reciprocating piston system, with a cylinder bore surface which is finished by machining in the form of a drilling process by means of a tool with one or more geometrically defined cutting edges, wherein the finished cylinder bore surface has a plurality of pores and/or or blowholes and is formed of a gray cast iron material with a pore area fraction of 2 to 10%, characterized in that the cylinder bore surface formed of gray cast iron material is finished by means of a sharp cutting edge in such a way that hard material particles contained in the gray cast iron material are torn out, wherein the sharp cutting edge has a cutting edge radius< 10 μm.
A bearing (1, 101) for a total or partial joint replacement prosthesis, the bearing having a body and a reinforcing element which strengthens the bearing and which forms an attachment member, the bearing being formed at least partially from a polymeric or composite material, the bearing further comprising a lower modulus portion and a higher modulus portion, characterised in that the higher modulus portion forms a tray-like structure in which the lower modulus portion is configured to sit, the tray-like structure providing bracing around a base and sides of the bearing but not around a top section, wherein the attachment member is configured to be attached to a total or partial joint replacement prosthesis.
A biomolecule analysis kit comprising: a reaction container configured to perform an enzymatic reaction, the reaction container includes a plurality of container-shaped portions configured so that a sample that becomes a target of analysis is supplied through a flow channel to the container-shaped portions and a base portion in which the container-shaped portions are formed; a cover portion superposed on the base portion to cover opening portions of the container-shaped portions, the flow channel being a space between the cover portion and the base portion; the base portion has a hydrophobic surface on a surface at a region positioned between the adjacent container shaped portions; a reagent configured to be supplied to the reaction container and used for the enzymatic reaction resulting in a signal which is configured to be detected, wherein the reagent contains an adsorption inhibitor for reducing an adsorption rate of at least one of the sample and the reagent with respect to the base portion; characterized in that a wash buffer is filled in the reaction container. a reaction container configured to perform an enzymatic reaction, the reaction container includes a plurality of container-shaped portions configured so that a sample that becomes a target of analysis is supplied through a flow channel to the container-shaped portions and a base portion in which the container-shaped portions are formed; a cover portion superposed on the base portion to cover opening portions of the container-shaped portions, the flow channel being a space between the cover portion and the base portion; the base portion has a hydrophobic surface on a surface at a region positioned between the adjacent container shaped portions; a reagent configured to be supplied to the reaction container and used for the enzymatic reaction resulting in a signal which is configured to be detected, wherein the reagent contains an adsorption inhibitor for reducing an adsorption rate of at least one of the sample and the reagent with respect to the base portion; characterized in that a wash buffer is filled in the reaction container.
A process for preparing a marinated extruded plant-based food product, the process comprising the steps of: a) feeding an extruder barrel with a composition comprising 40-70wt% water and 15-35wt% plant protein; b) extruding the composition from step a) above the texturization temperature of the plant protein, wherein the extruder barrels are heated to a temperature between 80-300°C; c) pushing the composition from step b) after the last extruder barrel through a constriction; d) cooling the composition from step c) through a cooling die; e) marinating the obtained extruded composition of step d) with a marinade; wherein the constriction reduces a cross-sectional area D constr compared to a cross-sectional area before the constriction D before between 30 to 95% and wherein a cross-sectional area after the constriction D after is increased again. a) feeding an extruder barrel with a composition comprising 40-70wt% water and 15-35wt% plant protein; b) extruding the composition from step a) above the texturization temperature of the plant protein, wherein the extruder barrels are heated to a temperature between 80-300°C; c) pushing the composition from step b) after the last extruder barrel through a constriction; d) cooling the composition from step c) through a cooling die; e) marinating the obtained extruded composition of step d) with a marinade;
A wind turbine, comprising a rotor, which is rotatable about a vertical axis under the action of an airflow, air-guiding elements surrounding the rotor externally, and a rotor shaft, which can be coupled or is coupled to a generator, wherein the rotor surrounds a flow channel, characterised in that the flow channel has a flow deflection surface for deflecting the airflow to an outlet opening, wherein the flow deflection surface is at least approximately conical or hyperbolic and has a rounded foot region, which rises in an inclined manner and borders an inclined lower surface of the rotor in the flow direction, wherein the lower surface and the foot region transition into one another continuously.
A coated substrate having an organometallic film deposited thereon; in which the substrate has oxide and/or hydroxyl groups that are inherent on the substrate surface or forms such groups on exposure to the environment; the organometallic film being a polymeric metal oxide having hydroxyl and alkoxide groups and being covalently bonded to the substrate surface through reaction of the surface oxide and/or hydroxyl groups with the alkoxide and/or hydroxyl groups associated with the polymeric metal oxide.
A method for reconstructing an incorrectly received data packet that has been transmitted in a wireless sensor network from a wireless node in form of data fields, which contain information that is known in advance, to a receiving unit, characterized in that - a first method and a second method for reconstructing the incorrectly received data packet are implemented in the receiving unit by using the information known in advance which is contained in the data fields, - in a first step, the first method for reconstructing the incorrectly received data packet is applied and a check is made for whether the data packet has thus been reconstructed, and - in a subsequent second step, the second method for reconstructing the incorrectly received data packet is applied if the incorrectly received data packet has not been reconstructed with the first method, and a check is made for whether the data packet has thus been reconstructed. - a first method and a second method for reconstructing the incorrectly received data packet are implemented in the receiving unit by using the information known in advance which is contained in the data fields, - in a first step, the first method for reconstructing the incorrectly received data packet is applied and a check is made for whether the data packet has thus been reconstructed, and - in a subsequent second step, the second method for reconstructing the incorrectly received data packet is applied if the incorrectly received data packet has not been reconstructed with the first method, and a check is made for whether the data packet has thus been reconstructed.
A cross-linked matrix, comprising a substrate polymer crosslinked by a modified enzyme molecule, said modified enzyme molecule having a modification that alters a perceived volume of the enzyme molecules in the crosslinked matrix as the matrix is being formed through cross-linking of said polymer.
A composition for dyeing keratin fibers, comprising: (a) at least one direct dye; and (b) at least one sulfone compound represented by the following formula: wherein each of R 1 and R 2 independently denotes a monovalent C 1-30 aliphatic group or a monovalent C 6-30 aromatic group, which may optionally be substituted with at least one substituent; or R 1 and R 2, together with the sulfur atom which they are binding, form a 3-10 membered ring which may optionally be substituted with at least one substituent. (a) at least one direct dye; and (b) at least one sulfone compound represented by the following formula: wherein each of R 1 and R 2 independently denotes a monovalent C 1-30 aliphatic group or a monovalent C 6-30 aromatic group, which may optionally be substituted with at least one substituent; or R 1 and R 2, together with the sulfur atom which they are binding, form a 3-10 membered ring which may optionally be substituted with at least one substituent. each of R 1 and R 2 independently denotes a monovalent C 1-30 aliphatic group or a monovalent C 6-30 aromatic group, which may optionally be substituted with at least one substituent; or R 1 and R 2, together with the sulfur atom which they are binding, form a 3-10 membered ring which may optionally be substituted with at least one substituent.
A process of separating and recovering fucose from a solution of a hydrolyzate of hemicellulose-containing biomass containing deoxysugars and other monosaccharides, comprising subjecting said solution to a process comprising the following steps using water as the eluent: at least one chromatographic fractionation using a column packing material selected from weakly acid cation exchange resins and weakly basic anion exchange resins, and at least one chromatographic fractionation using a column packing material selected from strongly basic anion exchange resins and optionally at least one chromatographic fractionation using a column packing material selected from strongly acid cation exchange resins, followed by recovering from fractionations and one or more fractions enriched in fucose. at least one chromatographic fractionation using a column packing material selected from weakly acid cation exchange resins and weakly basic anion exchange resins, and at least one chromatographic fractionation using a column packing material selected from strongly basic anion exchange resins and optionally at least one chromatographic fractionation using a column packing material selected from strongly acid cation exchange resins, followed by
Method for controlling loading/unloading of a material (5, 15) from a load-delivering unit (1, 11) to a load-receiving unit (2, 12) at a construction site, wherein at least one of the load-delivering unit and the load-receiving unit is a working machine vehicle (2, 11) in the form of a hauler or dump truck configured to transport a load of material from a first location to a second location, and wherein at least the load-delivering unit (1, 11) is provided with a control unit (7, 17) configured to control operation of the load-delivering unit (1, 11), characterized in that the method comprises the steps of: - receiving a first signal indicative of the material (5, 15) associated with the load-delivering unit (1, 11); - receiving a second signal indicative of the material intended to be received by the load-receiving unit (2, 12); - comparing material information related to the first signal with material information related to the second signal; - determining, based on said comparison, whether the material (5, 15) associated with the load-delivering unit (1, 11) is to be loaded/unloaded to the load-receiving unit (2, 12); and, when an outcome of the determining step is that the material (5, 15) associated with the load-delivering unit (1, 11) is not to be loaded/unloaded to the load-receiving unit (2, 12), - setting (S5a), by means of the control unit (7, 17), the load-delivering unit (1, 11) in a non-loading/non-unloading operation mode where a normal material dumping function of the load-delivering unit (1, 11) is disabled. - receiving a first signal indicative of the material (5, 15) associated with the load-delivering unit (1, 11); - receiving a second signal indicative of the material intended to be received by the load-receiving unit (2, 12); - comparing material information related to the first signal with material information related to the second signal; - determining, based on said comparison, whether the material (5, 15) associated with the load-delivering unit (1, 11) is to be loaded/unloaded to the load-receiving unit (2, 12); and, when an outcome of the determining step is that the material (5, 15) associated with the load-delivering unit (1, 11) is not to be loaded/unloaded to the load-receiving unit (2, 12), - setting (S5a), by means of the control unit (7, 17), the load-delivering unit (1, 11) in a non-loading/non-unloading operation mode where a normal material dumping function of the load-delivering unit (1, 11) is disabled.
Object confidence value generation system for generating confidence values for objects on a digital road map, having: - a backend; and - an object detection apparatus for a vehicle, the object detection apparatus having: - a capture unit; - an evaluation unit; - a positioning unit; and - a transmission/reception unit, wherein the capture unit is configured to capture surroundings data from a vehicle, wherein the positioning unit is configured to determine the position of the captured surroundings data and of the objects included therein, wherein the evaluation unit is configured to detect the objects and maskings of the objects in the surroundings data and to provide them with position information, wherein the transmission/reception unit is configured to transmit the data generated by the evaluation unit to the backend, wherein the backend is configured to receive the data of the transmission/reception unit and to generate or update the digital road map, wherein each of the objects on the digital road map of the backend has a confidence value; wherein the backend is configured to increase the confidence value of the respective object if the respective object is included in the received data, and wherein the backend is configured to reduce the confidence value of the respective object if the respective object is not included in the received data, wherein the backend is configured to respond to a masking of the object in the received data by not reducing the confidence value of the respective object. - a backend; and - an object detection apparatus for a vehicle, the object detection apparatus having: - a capture unit; - an evaluation unit; - a positioning unit; and - a transmission/reception unit, - a capture unit; - an evaluation unit; - a positioning unit; and - a transmission/reception unit, wherein the capture unit is configured to capture surroundings data from a vehicle, wherein the positioning unit is configured to determine the position of the captured surroundings data and of the objects included therein, wherein the evaluation unit is configured to detect the objects and maskings of the objects in the surroundings data and to provide them with position information, wherein the transmission/reception unit is configured to transmit the data generated by the evaluation unit to the backend, wherein the backend is configured to receive the data of the transmission/reception unit and to generate or update the digital road map, wherein each of the objects on the digital road map of the backend has a confidence value; wherein the backend is configured to increase the confidence value of the respective object if the respective object is included in the received data, and wherein the backend is configured to reduce the confidence value of the respective object if the respective object is not included in the received data, wherein the backend is configured to respond to a masking of the object in the received data by not reducing the confidence value of the respective object.