Microfluidic valve for controlling flow of a liquid in a microfluidic channel comprising a basic substrate, an elastomeric membrane with a thickness d EM = d in relaxed state, and a top substrate respectively having opposed upper and lower surfaces, wherein the top substrate is secured to the basic substrate thereby clenching the elastomeric membrane between the upper surface of the basic substrate and the lower surface of the top substrate, characterized in that the basic substrate comprises on its upper surface a valve seat with a perimeter pv = x comprising a central recess with a perimeter p CR ≤ x, and a projection surrounding the valve seat with an inner perimeter p Pi ≥ x and an outer perimeter p Po > p Pi, wherein a distance between the upper surface of the basic substrate and the lower surface plane of the top substrate measured perpendicular to the lower surface plane respectively is d BTLS ≥ d outside the perimeter p Po of the projection, is d CR > d within the perimeter p CR of the central recess, and is dp < d between the perimeters p Pi and p Po of the projection, wherein the top substrate has a through hole from its lower to upper surface with a perimeter p TH ≤ p Pi, which is arranged in register to the valve seat thereby providing access for a valve actuator means, wherein the central recess comprises an inlet opening and a separate outlet opening, which are respectively connected to microfluidic channels upstream and downstream (MC UP and MC DOWN) of the valve by respective connection channels, and wherein the connection channels are independently of each other arranged in angular position to the upper surface of the basic substrate, and the elastomeric membrane is configured to not be in contact with the surface of the central recess in open valve state thereby forming a valve cavity, which fluidicly connects the connection channels upstream and downstream (MC UP and MC DOWN) of the valve, and to be deformable by the valve actuator means so that in closed valve state the elastomeric membrane closes the fluidic connection between the inlet and outlet openings (1121,1122) in the central recess, characterized in that the central recess forms on the upper surface of the basic substrate a recess of longitudinal shape. wherein a distance between the upper surface of the basic substrate and the lower surface plane of the top substrate measured perpendicular to the lower surface plane respectively is d BTLS ≥ d outside the perimeter p Po of the projection, is d CR > d within the perimeter p CR of the central recess, and is dp < d between the perimeters p Pi and p Po of the projection, wherein the top substrate has a through hole from its lower to upper surface with a perimeter p TH ≤ p Pi, which is arranged in register to the valve seat thereby providing access for a valve actuator means, wherein the central recess comprises an inlet opening and a separate outlet opening, which are respectively connected to microfluidic channels upstream and downstream (MC UP and MC DOWN) of the valve by respective connection channels, and wherein the connection channels are independently of each other arranged in angular position to the upper surface of the basic substrate, and the elastomeric membrane is configured to not be in contact with the surface of the central recess in open valve state thereby forming a valve cavity, which fluidicly connects the connection channels upstream and downstream (MC UP and MC DOWN) of the valve, and to be deformable by the valve actuator means so that in closed valve state the elastomeric membrane closes the fluidic connection between the inlet and outlet openings (1121,1122) in the central recess, characterized in that the central recess forms on the upper surface of the basic substrate a recess of longitudinal shape.