A compound having the structure of the Formula or Formula: or a pharmaceutically acceptable salt thereof, wherein: G is selected from the group consisting of -OR 1 -C R 1, -C (CH 2) 0-3 SR 1, - C (CH 2) 1-3 R 1, -C OR 1, -C NR 1 R 2, -C NR 1 OR 2, -N 3, -NR 1 R 2, -NR 1 C R 2, - NR 1 C NR 2 R 3, -NR 1 C OR 2, -NR 1 S 2 R 2, -NR 1 S 2 NR 2 R 3, -C(=NR 1)R 2, - C(=NR 1)NR 2 R 3, -NR 1 CR 2 (=NR 3), -NR 1 C(=NR 2)NR 3 R 4, -S 2 R 1, optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted C 3-7 carbocyclyl-C 1-6 alkyl, optionally substituted 5-10 membered heterocyclyl-C 1-6 alkyl, optionally substituted C 6-10 aryl-C 1-6 alkyl, and optionally substituted 5-10 membered heteroaryl-C 1-6 alkyl; R 1, R 2, R 3, and R 4 are each independently selected from the group consisting of -H, optionally substituted C 1-4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted C 6-10 aryl-C 1-6 alkyl, and optionally substituted 5-10 membered heteroaryl; J is selected from the group consisting of CR 5 and N; L is selected from the group consisting of CR 6 and N; M is selected from the group consisting of CR 7 and N; R 5, R 6, and R 7 are each independently selected from the group cosnsisting of -H, -OR 8, halogen, -CF 3, optionally subsituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally subsituted C 1 -C 6 heteroalkyl, optionally subsituted C 3 -C 7 carbocyclyl, optionally subsituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, cyano, C 1 -C 6 alkoxy(C 1 -C 6)alkyl, aryloxy, and sulfhydryl (mercapto); R 8 is selected from the group consisting of hydrogen, optionally substituted C 1 - 4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl; R is selected from the group consisting of -H, -C 1-9 alkyl, -CR 9 R 10 OC C 1-9 alkyl, - CR 9 R 10 OC OC 1-9 alkyl, -CR 9 R 10 OC C 6-10 aryl, -CR 9 R 10 OC OC 6-10 aryl,, -CR 9 R 10 OC C 3-7 carbocyclyl, -CR 9 R 10 OC OC 3-7 carbocyclyl, -CR 9 R 10 OC (5-10 membered heterocyclyl), and -CR 9 R 10 OC O(5-10 membered heterocyclyl); and R 9 and R 10 are independently selected from the group consisting of -H, optionally substituted C 1 - 4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl. G is selected from the group consisting of -OR 1 -C R 1, -C (CH 2) 0-3 SR 1, - C (CH 2) 1-3 R 1, -C OR 1, -C NR 1 R 2, -C NR 1 OR 2, -N 3, -NR 1 R 2, -NR 1 C R 2, - NR 1 C NR 2 R 3, -NR 1 C OR 2, -NR 1 S 2 R 2, -NR 1 S 2 NR 2 R 3, -C(=NR 1)R 2, - C(=NR 1)NR 2 R 3, -NR 1 CR 2 (=NR 3), -NR 1 C(=NR 2)NR 3 R 4, -S 2 R 1, optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted C 3-7 carbocyclyl-C 1-6 alkyl, optionally substituted 5-10 membered heterocyclyl-C 1-6 alkyl, optionally substituted C 6-10 aryl-C 1-6 alkyl, and optionally substituted 5-10 membered heteroaryl-C 1-6 alkyl; R 1, R 2, R 3, and R 4 are each independently selected from the group consisting of -H, optionally substituted C 1-4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted C 6-10 aryl-C 1-6 alkyl, and optionally substituted 5-10 membered heteroaryl; J is selected from the group consisting of CR 5 and N; L is selected from the group consisting of CR 6 and N; M is selected from the group consisting of CR 7 and N; R 5, R 6, and R 7 are each independently selected from the group cosnsisting of -H, -OR 8, halogen, -CF 3, optionally subsituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally subsituted C 1 -C 6 heteroalkyl, optionally subsituted C 3 -C 7 carbocyclyl, optionally subsituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, cyano, C 1 -C 6 alkoxy(C 1 -C 6)alkyl, aryloxy, and sulfhydryl (mercapto); R 8 is selected from the group consisting of hydrogen, optionally substituted C 1 - 4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl; R is selected from the group consisting of -H, -C 1-9 alkyl, -CR 9 R 10 OC C 1-9 alkyl, - CR 9 R 10 OC OC 1-9 alkyl, -CR 9 R 10 OC C 6-10 aryl, -CR 9 R 10 OC OC 6-10 aryl,, -CR 9 R 10 OC C 3-7 carbocyclyl, -CR 9 R 10 OC OC 3-7 carbocyclyl, -CR 9 R 10 OC (5-10 membered heterocyclyl), and -CR 9 R 10 OC O(5-10 membered heterocyclyl); and R 9 and R 10 are independently selected from the group consisting of -H, optionally substituted C 1 - 4 alkyl, optionally substituted C 3-7 carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl.