A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: ZisO; X is C(R 5) 2 and ------ is a single bond; either: R 1 is aryl optionally substituted with one or more R 4, wherein each R 4 is halogen, hydroxyl, haloalkyl, -Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, -L-N(R 5) 2, -Y 1 -N(R 5) 2, -Y 2 -N(R 5) 2, Y 2 -haloalkyl, L-heterocyclyl, or Y 1 -heterocyclyl, wherein the heterocyclyl portion of the L-heterocyclyl, or Y 1 -heterocyclyl is optionally substituted with one or more R 7; or: R' is heteroaryl optionally substituted with one or more R 4, wherein each R 4 is amino, cyano, halogen, alkoxy, hydroxyalkyl, heteroalkyl, haloalkyl, Y 2 -haloalkyl, Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, L-cycloalkyl, L-heteroaryl, L-heterocyclyl, Y 1 -heterocyclyl, -L-N(R 5) 2, or -Y 1 -N(R 5) 2, wherein the ring of the L-cycloalkyl, L-heteroaryl, L-heterocyclyl or Y 1 -heterocyclyl is optionally substituted with one or more R 7; R 2 is cyano; R 3 is halogen; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or -NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1. or a pharmaceutically acceptable salt thereof, wherein: ZisO; X is C(R 5) 2 and ------ is a single bond; either: R 1 is aryl optionally substituted with one or more R 4, wherein each R 4 is halogen, hydroxyl, haloalkyl, -Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, -L-N(R 5) 2, -Y 1 -N(R 5) 2, -Y 2 -N(R 5) 2, Y 2 -haloalkyl, L-heterocyclyl, or Y 1 -heterocyclyl, wherein the heterocyclyl portion of the L-heterocyclyl, or Y 1 -heterocyclyl is optionally substituted with one or more R 7; or: R' is heteroaryl optionally substituted with one or more R 4, wherein each R 4 is amino, cyano, halogen, alkoxy, hydroxyalkyl, heteroalkyl, haloalkyl, Y 2 -haloalkyl, Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, L-cycloalkyl, L-heteroaryl, L-heterocyclyl, Y 1 -heterocyclyl, -L-N(R 5) 2, or -Y 1 -N(R 5) 2, wherein the ring of the L-cycloalkyl, L-heteroaryl, L-heterocyclyl or Y 1 -heterocyclyl is optionally substituted with one or more R 7; R 2 is cyano; R 3 is halogen; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or -NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1. ZisO; X is C(R 5) 2 and ------ is a single bond; either: R 1 is aryl optionally substituted with one or more R 4, wherein each R 4 is halogen, hydroxyl, haloalkyl, -Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, -L-N(R 5) 2, -Y 1 -N(R 5) 2, -Y 2 -N(R 5) 2, Y 2 -haloalkyl, L-heterocyclyl, or Y 1 -heterocyclyl, wherein the heterocyclyl portion of the L-heterocyclyl, or Y 1 -heterocyclyl is optionally substituted with one or more R 7; or: R' is heteroaryl optionally substituted with one or more R 4, wherein each R 4 is amino, cyano, halogen, alkoxy, hydroxyalkyl, heteroalkyl, haloalkyl, Y 2 -haloalkyl, Y 1 -C1 - C6 alkyl, Y 2 -C1 - C6 alkyl, L-cycloalkyl, L-heteroaryl, L-heterocyclyl, Y 1 -heterocyclyl, -L-N(R 5) 2, or -Y 1 -N(R 5) 2, wherein the ring of the L-cycloalkyl, L-heteroaryl, L-heterocyclyl or Y 1 -heterocyclyl is optionally substituted with one or more R 7; R 2 is cyano; R 3 is halogen; L is a bond or C1 - C4 alkylene; Y 1 is a bond, -C -, or -NHC -; Y 2 is a bond, -S-, -SO-, -SO 2 -, or -NR 5 SO 2 -; each R 5 is hydrogen or C1 - C3 alkyl; R 6 is hydrogen, C1 - C3 alkyl, halogen, haloalkyl, hydroxyalkyl, or heteroalkyl; each R 7 is oxo, cyano, hydroxyl, alkoxy, halogen, haloalkyl, hydroxyalkyl, heteroalkyl, cycloalkyl, -L-N(R 5) 2, C1 - C6 alkyl or -Y 1 -heterocyclyl; and n is 1.