Process for the preparation of prostaglandin amides of the general formula, - where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q represents hydroxyl-group and Z represents hydroxyl- or oxo- group, R 1 and R 2 independently represent hydrogen atom or a straight or branched C 1-10 alkyl- or aralkyl- group, optionally substituted with -ONO 2 group, or an aralkyl- or aryl- group, which contains heteroatom, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or phenyl-, C 7-10 alkylaryl- or hetaryl- group, optionally substituted with alkyl group or halogen atom, Y represents (CH 2) n group or O atom or S atom, and where n=0-3, characterized in that an acid of the general formula, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q represents hydroxyl-group and Z represents hydroxyl- or oxo- group, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or phenyl-, C 7-10 alkylaryl- or hetaryl- group, optionally substituted with alkyl group or halogen atom, Y represents (CH 2) n group or O atom or S atom, and where n=0-3, is reacted with a compound suitable to introduce group R 5, where R 5 represents a group of formula b.), d.) or e.), where stands for halogen or hydrogen atom - and reacting the activated ester of the general formula, thus obtained where the meanings of Q, Z, R 3, R 5, Y and n are as defined above, with an amine of the general formula, NHR 1 R 2 IV. where the meanings of R 1 and R 2 are as defined above. - where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q represents hydroxyl-group and Z represents hydroxyl- or oxo- group, R 1 and R 2 independently represent hydrogen atom or a straight or branched C 1-10 alkyl- or aralkyl- group, optionally substituted with -ONO 2 group, or an aralkyl- or aryl- group, which contains heteroatom, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or phenyl-, C 7-10 alkylaryl- or hetaryl- group, optionally substituted with alkyl group or halogen atom, Y represents (CH 2) n group or O atom or S atom, and where n=0-3, characterized in that an acid of the general formula, the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q represents hydroxyl-group and Z represents hydroxyl- or oxo- group, R 1 and R 2 independently represent hydrogen atom or a straight or branched C 1-10 alkyl- or aralkyl- group, optionally substituted with -ONO 2 group, or an aralkyl- or aryl- group, which contains heteroatom, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or phenyl-, C 7-10 alkylaryl- or hetaryl- group, optionally substituted with alkyl group or halogen atom, Y represents (CH 2) n group or O atom or S atom, and where n=0-3, characterized in that an acid of the general formula, the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q represents hydroxyl-group and Z represents hydroxyl- or oxo- group, R 3 represents a straight or branched, saturated or unsaturated C 4-6 hydrocarbon group, or a C 4-10 alkylcycloalkyl- or cycloalkyl- group, or phenyl-, C 7-10 alkylaryl- or hetaryl- group, optionally substituted with alkyl group or halogen atom, Y represents (CH 2) n group or O atom or S atom, and where n=0-3, is reacted with a compound suitable to introduce group R 5, where R 5 represents