A method for producing an antigen-binding molecule comprising an antigen-binding domain whose antigen-binding activity varies depending on the concentration of a small molecule compound, which comprises the steps of: (a) contacting a library with an antigen in the absence of a small molecule compound; (b) selecting an antigen-binding domain that does not bind to the antigen in step (a) above; (c) contacting the antigen-binding domain selected in step (b) above with the antigen in the presence of the small molecule compound; (d) selecting the antigen-binding domain that binds to the antigen in step (c) above; (e) linking the polynucleotide that encodes the antigen-binding domain selected in step (d) above with a polynucleotide that encodes a polypeptide comprising an Fc region; (f) culturing a cell introduced with a vector in which the polynucleotide obtained in step (e) above is operably linked; and (g) collecting the antigen-binding molecule from the culture solution of the cell cultured in step (f) above, wherein the library used in step (a) is produced by the method comprising the steps of: contacting a library comprising a plurality of antigen-binding molecules having binding activity to a small molecule compound with the small molecule compound; and concentrating nucleic acids from the library, wherein the nucleic acids encode a plurality of variants of antigen-binding molecules having binding activity to the small molecule compound, wherein the produced library comprises mainly: (i) a plurality of antigen-binding molecules comprising an antigen-binding domain, which have different sequences from one another; or (ii) nucleic acids that encode the plurality of antigen-binding molecules comprising an antigen-binding domain, which have different sequences from one another, wherein the antigen-binding domain comprises an antibody heavy chain variable region and an antibody light chain variable region, wherein the small molecule compound is a cancer tissue specific compound and is at least one compound selected from the group consisting of nucleosides that have a purine ring structure, amino acids and their metabolites, lipids and their metabolites, primary metabolites from sugar metabolism, and nicotinamide and its metabolites. (a) contacting a library with an antigen in the absence of a small molecule compound; (b) selecting an antigen-binding domain that does not bind to the antigen in step (a) above; (c) contacting the antigen-binding domain selected in step (b) above with the antigen in the presence of the small molecule compound; (d) selecting the antigen-binding domain that binds to the antigen in step (c) above; (e) linking the polynucleotide that encodes the antigen-binding domain selected in step (d) above with a polynucleotide that encodes a polypeptide comprising an Fc region; (f) culturing a cell introduced with a vector in which the polynucleotide obtained in step (e) above is operably linked; and (g) collecting the antigen-binding molecule from the culture solution of the cell cultured in step (f) above, contacting a library comprising a plurality of antigen-binding molecules having binding activity to a small molecule compound with the small molecule compound; and concentrating nucleic acids from the library, wherein the nucleic acids encode a plurality of variants of antigen-binding molecules having binding activity to the small molecule compound, (i) a plurality of antigen-binding molecules comprising an antigen-binding domain, which have different sequences from one another; or (ii) nucleic acids that encode the plurality of antigen-binding molecules comprising an antigen-binding domain, which have different sequences from one another, wherein the antigen-binding domain comprises an antibody heavy chain variable region and an antibody light chain variable region,