mhurhangee/ep-ind-claims huggingface dataset:
A structure comprising: a semiconductor light emitting device capable of emitting first light having a first peak wavelength; and a semiconductor wavelength converting element capable of absorbing the first light and emitting second light having a second peak wavelength; wherein: the semiconductor wavelength converting element is attached to a support and disposed in a path of light emitted by the semiconductor light emitting device, wherein the support is capable of emitting third light having a third peak wavelength; and the semiconductor wavelength converting element includes regions of semiconductor wavelength converting material, characterized in that, the support is a ceramic phosphor, the wavelength converting element is patterned to include at least two first regions and at least one second region without semiconductor wavelength material disposed between the at least two first regions, a surface of the semiconductor wavelength converting element is passivated, and the total thickness of the semiconductor wavelength converting elements is 5 μm or less. a semiconductor light emitting device capable of emitting first light having a first peak wavelength; and a semiconductor wavelength converting element capable of absorbing the first light and emitting second light having a second peak wavelength; wherein: the semiconductor wavelength converting element is attached to a support and disposed in a path of light emitted by the semiconductor light emitting device, wherein the support is capable of emitting third light having a third peak wavelength; and the semiconductor wavelength converting element includes regions of semiconductor wavelength converting material, the semiconductor wavelength converting element is attached to a support and disposed in a path of light emitted by the semiconductor light emitting device, wherein the support is capable of emitting third light having a third peak wavelength; and the semiconductor wavelength converting element includes regions of semiconductor wavelength converting material, characterized in that, the support is a ceramic phosphor, the wavelength converting element is patterned to include at least two first regions and at least one second region without semiconductor wavelength material disposed between the at least two first regions, a surface of the semiconductor wavelength converting element is passivated, and the total thickness of the semiconductor wavelength converting elements is 5 μm or less.
An audio system comprising: an audio driver configured to receive a target audio signal and a feedback signal and to generate an adjusted audio signal responsive to the target audio signal and the feedback signal; a loudspeaker configured to convert the adjusted audio signal into acoustical sound; a test signal generator coupled to a power supply input of the audio driver and configured to generate a test signal having a higher frequency than the target audio signal and to adjust a power supply of the audio driver with the test signal to generate an adjusted power supply for the audio driver that introduces variations in the adjusted audio signal causing a test current to flow through the loudspeaker; a current sensing circuit configured to measure the test current flowing through the loudspeaker and to generate a current sense signal indicative of the test current; and a feedback circuit configured to generate the feedback signal responsive to the current sense signal. an audio driver configured to receive a target audio signal and a feedback signal and to generate an adjusted audio signal responsive to the target audio signal and the feedback signal; a loudspeaker configured to convert the adjusted audio signal into acoustical sound; a test signal generator coupled to a power supply input of the audio driver and configured to generate a test signal having a higher frequency than the target audio signal and to adjust a power supply of the audio driver with the test signal to generate an adjusted power supply for the audio driver that introduces variations in the adjusted audio signal causing a test current to flow through the loudspeaker; a current sensing circuit configured to measure the test current flowing through the loudspeaker and to generate a current sense signal indicative of the test current; and a feedback circuit configured to generate the feedback signal responsive to the current sense signal.
Compound of the formula in which R 1, R 2 and R 3 independently of one another represent hydrogen or methyl, L represents a bond or represents -CH 2 -, R 4A and R 4B independently of one another represent methyl, trifluoromethyl or ethyl or R 4A and R 4B are attached to one another and together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring which may be substituted up to two times by fluorine, R 5 represents hydrogen, fluorine, methyl or methoxy, R 6 represents hydrogen, fluorine, chlorine, bromine, cyano, methyl, trifluoromethyl, ethyl, methoxy or trifluoromethoxy, R 7 represents hydrogen, fluorine, chlorine or methyl, R 8A represents methyl or ethyl, R 8B represents trifluoromethyl, or R 8A and R 8B are attached to one another and together with the carbon atom to which they are attached form an optionally difluoro-substituted cyclopentyl ring of the formula R 9 represents fluorine, chlorine, bromine, cyano, (C 1 -C 4)-alkyl, (C 2 -C 4)-alkenyl, cyclopropyl or cyclobutyl, where (C 1 -C 4)-alkyl and (C 2 -C 4)-alkenyl may be substituted up to three times by fluorine and cyclopropyl and cyclobutyl may be substituted up to two times by fluorine, and R 10 represents hydrogen, fluorine, chlorine, methyl, trifluoromethyl, ethyl or methoxy, and salts, solvates and solvates of the salts thereof. R 1, R 2 and R 3 independently of one another represent hydrogen or methyl, L represents a bond or represents -CH 2 -, R 4A and R 4B independently of one another represent methyl, trifluoromethyl or ethyl or R 4A and R 4B are attached to one another and together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring which may be substituted up to two times by fluorine, R 5 represents hydrogen, fluorine, methyl or methoxy, R 6 represents hydrogen, fluorine, chlorine, bromine, cyano, methyl, trifluoromethyl, ethyl, methoxy or trifluoromethoxy, R 7 represents hydrogen, fluorine, chlorine or methyl, R 8A represents methyl or ethyl, R 8B represents trifluoromethyl, or R 8A and R 8B are attached to one another and together with the carbon atom to which they are attached form an optionally difluoro-substituted cyclopentyl ring of the formula R 9 represents fluorine, chlorine, bromine, cyano, (C 1 -C 4)-alkyl, (C 2 -C 4)-alkenyl, cyclopropyl or cyclobutyl, where (C 1 -C 4)-alkyl and (C 2 -C 4)-alkenyl may be substituted up to three times by fluorine and cyclopropyl and cyclobutyl may be substituted up to two times by fluorine, and R 10 represents hydrogen, fluorine, chlorine, methyl, trifluoromethyl, ethyl or methoxy,
A method of making a dental restoration, comprising the steps of: providing a three-dimensional virtual model of a dental restoration representing at least a final outer surface of the dental restoration; separate therefrom, providing a three-dimensional virtual model of an anterior incisal portion of a patient's tooth, wherein the three-dimensional virtual model of the anterior incisal portion in two dimensions is based on a two-dimensional virtual incisal area model and in the third dimension on a predetermined offset of the two-dimensional virtual incisal area model; superimposing the virtual model of the dental restauration and the virtual model of the anterior incisal portion; automatically recessing the virtual model of the dental restauration in which the virtual model of the dental restauration and the virtual model of the anterior incisal portion are superposed, and thereby creating a reduced virtual dental restoration model; transmitting data representative of the reduced virtual dental restoration model to a machine for manufacturing dental restorations; manufacturing a dental restoration precursor or a reduced dental restoration based on the data; and manually adding a material layer to the reduced dental restoration, thus providing the reduced dental restoration with an incisal layer, and thereby creating the dental restoration providing a three-dimensional virtual model of a dental restoration representing at least a final outer surface of the dental restoration; separate therefrom, providing a three-dimensional virtual model of an anterior incisal portion of a patient's tooth, wherein the three-dimensional virtual model of the anterior incisal portion in two dimensions is based on a two-dimensional virtual incisal area model and in the third dimension on a predetermined offset of the two-dimensional virtual incisal area model; superimposing the virtual model of the dental restauration and the virtual model of the anterior incisal portion; automatically recessing the virtual model of the dental restauration in which the virtual model of the dental restauration and the virtual model of the anterior incisal portion are superposed, and thereby creating a reduced virtual dental restoration model; transmitting data representative of the reduced virtual dental restoration model to a machine for manufacturing dental restorations; manufacturing a dental restoration precursor or a reduced dental restoration based on the data; and manually adding a material layer to the reduced dental restoration, thus providing the reduced dental restoration with an incisal layer, and thereby creating the dental restoration
A dye-free acetaminophen (APAP) suspension, comprising: (a) a therapeutically effective amount of APAP having an average particle size of between about 10 and about 100 microns, (b) an effective amount of a non-reducing sweetener comprising a combination of sucrose and sorbitol; (c) from 25 to 60 grams per 100 mL of the suspension of water; (d) an effective amount of a suspending system; wherein the dye-free pharmaceutical suspension has a pH of from 5.1 to 5.9 and is substantially free of a reducing sugar. (a) a therapeutically effective amount of APAP having an average particle size of between about 10 and about 100 microns, (b) an effective amount of a non-reducing sweetener comprising a combination of sucrose and sorbitol; (c) from 25 to 60 grams per 100 mL of the suspension of water; (d) an effective amount of a suspending system;
Testosterone or a metabolite or precursor thereof and a 5-HT1A agonist for use in the treatment of sexual dysfunction, wherein said 5-HT1A agonist is essentially released between one hour and 1.5 hours before and said testosterone or a metabolite or precursor thereof 3.5-5.5 hours prior to sexual activity so that the peak effects of the 5-HT1A agonist and testosterone or a metabolite or precursor thereof partly overlap.
Headphones or a headset comprising at least one housing with an acoustic radiator having a planar magnetic system placed therein, and comprising an ear cup cushion located on the outer surface of the radiator, the acoustic radiator being driven by the planar magnetic system, wherein the ear cup cushion and the housing is performed detachable, wherein the ear cup cushion is rigidly connected to at least one acoustically transparent ferromagnetic screen connected to the housing by means of an interaction of the ferromagnetic screen with the magnetic field of the planar magnetic system on the outer surface of the radiator, and the magnetic conductivity of the ferromagnetic screen is sufficient to increase the magnetic induction in a gap of the magnetic system of the radiator and to hold the ear cup cushion with a ferromagnetic shield on the housing and wherein the ferromagnetic screen is in the form of a net or a perforated plate and through-holes area of the ferromagnetic screen is from 40% to 80% of the total screen area.
An immunogenic peptide or polypeptide comprising: at least two distinct antigenic peptide epitope sequences selected from a plurality of viral or microbial pathogens, and arranged in a non-natural order as compared to the native protein from which they are derived; wherein at least one of the antigenic epitopes comprises an isolated amino acid sequence that consists of an amino acid sequence that is at least 95% identical to the sequence of any one of SEQ ID NOs: 7and 17. at least two distinct antigenic peptide epitope sequences selected from a plurality of viral or microbial pathogens, and arranged in a non-natural order as compared to the native protein from which they are derived; wherein at least one of the antigenic epitopes comprises an isolated amino acid sequence that consists of an amino acid sequence that is at least 95% identical to the sequence of any one of SEQ ID NOs: 7and 17.
A production plant for laying fiber tapes, the production plant comprising: - a laying device having an unwinder receptacle and at least two unwinders arranged next to one another on the unwinder receptacle, which unwinders each comprise a receiving device for receiving a raw material reel and a cutting unit for cutting the fiber tape; - a depositing device having a depositing surface for receiving the fiber tape unwound from the raw material reel, the depositing surface of the depositing device and the unwinder of the laying device being displaceable relative to one another in the laying direction, whereby the fiber tape can be unwound in stripes onto the depositing surface, characterized in that the at least two unwinders are coupled to an unwinder receptacle of the laying device by means of a linear guide and are movable independently of each other in the laying direction relative to the unwinder receptacle. - a laying device having an unwinder receptacle and at least two unwinders arranged next to one another on the unwinder receptacle, which unwinders each comprise a receiving device for receiving a raw material reel and a cutting unit for cutting the fiber tape; - a depositing device having a depositing surface for receiving the fiber tape unwound from the raw material reel, the depositing surface of the depositing device and the unwinder of the laying device being displaceable relative to one another in the laying direction, whereby the fiber tape can be unwound in stripes onto the depositing surface,
A method for producing a protein refolding column filler consisting of a starch adhesive material and zeolite with BEA structure (Zeolite Beta) that is granulated into particles having a particle diameter between 20 and 1,000 μm, which method comprises adding the starch adhesive material to Zeolite Beta by spraying or dropping it to the material powders of the Zeolite Beta, while rotating and/or stirring them, and then granulating the obtained mixture so as to obtain the granulated Zeolite Beta.
A rotary machine for acting on a process fluid, comprising an impeller for acting on the process fluid, a shaft, on which the impeller is mounted, a drive unit operatively connected to the shaft for rotating the shaft and the impeller about an axial direction, a sealing unit having a sealing element for sealing the shaft during rotation of the shaft, and a flush casing configured to receive a flushing fluid for flushing the sealing element, wherein the flush casing is configured to delimit an annular flush chamber extending about the sealing element, and wherein the flush casing comprises a bushing surrounding the sealing element and delimiting a radial leakage gap arranged between the sealing element and the bushing, characterized in that the bushing is arranged and configured to delimit an axial leakage gap between the impeller and the bushing, wherein the width of the axial leakage gap in the axial direction is adjustable due to the flush casing being configured to be movable in the axial direction.
A method (Q10, S20) for processing a pressure sensing signal, comprising the steps: providing a pressure sensitive module; acquiring a resistance of the pressure sensitive module and recording a resistance-time curve (Q11; S104); first-order differentiating the resistance-time curve and acquiring the corresponding slope value (Q12; S105); matching the slope value with at least one predetermined database to acquire a pressing force gradient corresponding to the slope value (Q13; S108); and calculating and acquiring a pressing force based on the pressing force gradient (Q14;S109). providing a pressure sensitive module; acquiring a resistance of the pressure sensitive module and recording a resistance-time curve (Q11; S104); first-order differentiating the resistance-time curve and acquiring the corresponding slope value (Q12; S105); matching the slope value with at least one predetermined database to acquire a pressing force gradient corresponding to the slope value (Q13; S108); and calculating and acquiring a pressing force based on the pressing force gradient (Q14;S109).
A hybrid heat sink system, comprising an integrally formed plastic heat sink (22, 82) and an insert (20, 84), the plastic heat sink (22, 82) comprises a thermally conductive plastic, the plastic heat sink (22, 82) and the insert (20, 84) each having a cylindrical shape, the insert (20, 84) being arranged inside the heat sink (22, 82) and in thermal contact therewith, which comprises a printed circuit board package, and wherein the heat sink system is free of independent attachment elements that attach the printed circuit board package to the plastic heat sink (22, 82); characterized in that the printed circuit board package is in direct thermal contact with the plastic heat sink (22, 82), the plastic heat sink (22, 82) is arranged around the insert (20, 84) and in direct thermal contact therewith, the heat sink system is free of thermal interface materials, free of connectors, and free of separate metal inserts; and the heat sink system further comprising at least one of the following features: the insert (20, 84) comprising corrugations, the insert (20, 84) comprising lancing provisions and the lancing provisions comprising openings formed by protrusions extending into the insert (20, 84), with the thermally conductive plastic extending into the openings, the plastic heat sink (22, 82) comprising radially extending fins with holes located between the fins, and the insert (22, 84) comprising embossing. the insert (20, 84) comprising corrugations, the insert (20, 84) comprising lancing provisions and the lancing provisions comprising openings formed by protrusions extending into the insert (20, 84), with the thermally conductive plastic extending into the openings, the plastic heat sink (22, 82) comprising radially extending fins with holes located between the fins, and the insert (22, 84) comprising embossing.
A compact for carrying a cosmetic, the compact comprising: a base, a tray for storing the cosmetic, the tray being pivotable with respect to the base from a first position to a second position, characterized in that the tray comprises a key for engaging the base in a longitudinal direction. a base, a tray for storing the cosmetic, the tray being pivotable with respect to the base from a first position to a second position, characterized in that the tray comprises a key for engaging the base in a longitudinal direction.
A method for producing an herbicide-resistant plant, said method comprising: (a) introducing into a plant cell a single stranded gene repair oligonucleobase (GRON) with a targeted mutation in an acetohydroxyacid synthase (AHAS) gene to produce a plant cell with: (i) an AHAS gene that expresses an AHAS protein comprising an alanine to valine or aspartic acid substitution at a position corresponding to position 205 of SEQ ID NO: 1, and (ii) an AHAS gene that expresses an AHAS protein comprising a serine to asparagine substitution at a position corresponding to position 653 of SEQ ID NO: 1; (b) identifying a plant cell having substantially normal growth and catalytic activity as compared to a corresponding wild-type plant cell in the presence of an AHAS-inhibiting herbicide; and (c) regenerating a non-transgenic herbicide-resistant plant having a mutated AHAS gene from said plant cell. (a) introducing into a plant cell a single stranded gene repair oligonucleobase (GRON) with a targeted mutation in an acetohydroxyacid synthase (AHAS) gene to produce a plant cell with: (i) an AHAS gene that expresses an AHAS protein comprising an alanine to valine or aspartic acid substitution at a position corresponding to position 205 of SEQ ID NO: 1, and (ii) an AHAS gene that expresses an AHAS protein comprising a serine to asparagine substitution at a position corresponding to position 653 of SEQ ID NO: 1; (i) an AHAS gene that expresses an AHAS protein comprising an alanine to valine or aspartic acid substitution at a position corresponding to position 205 of SEQ ID NO: 1, and (ii) an AHAS gene that expresses an AHAS protein comprising a serine to asparagine substitution at a position corresponding to position 653 of SEQ ID NO: 1; (b) identifying a plant cell having substantially normal growth and catalytic activity as compared to a corresponding wild-type plant cell in the presence of an AHAS-inhibiting herbicide; and (c) regenerating a non-transgenic herbicide-resistant plant having a mutated AHAS gene from said plant cell.
A radiator assembly for heat transfer by combining radiation and convection, comprising a housing which comprises a front wall for the static heat dissipation by means of radiation, at least one pipe system in form of a pipe register for making pass a heating/cooling medium, at least one distribution body made of graphite for homogenizing the temperature distribution, characterized in that the housing is configured as a cassette-like body having openings and comprising a base plate and a circumferential border in which the openings are arranged, wherein the radiator assembly comprises at least one additional heat exchanger unit in form of a lamella pack as well as at least one ventilator, by means of which ventilator the heat transfer realized by means of convection can be adapted according to the needs.
An antibody-antibiotic conjugate compound comprising an anti-wall teichoic acid monoclonal antibody, wherein the anti-WTA antibody binds to Staphylococcus aureus, and covalently attached by a S. aureus endopeptidase or cysteine protease cleavable, peptide linker to an antibiotic moiety selected from sitafloxacin and teicoplanin; wherein the antibody-antibiotic conjugate compound has: Ab-(L-abx) p wherein: Ab is the anti-wall teichoic acid antibody; L is the peptide linker having the formula: -Str-Pep-Y- where Str is a stretcher unit; Pep is a peptide of two to twelve amino acid residues, and Y is a spacer unit; abx is the antibiotic moiety; and p is an integer from 1 to 8; wherein (a) the VL of the anti-WTA monoclonal antibody comprises CDR L1 comprising the sequence of KSSQSIFRTSRNKNLLN (SEQ ID NO:99), CDR L2 comprising the sequence of WASTRKS (SEQ ID NO: 100), and CDR L3 comprising the sequence of QQYFSPPYT (SEQ ID NO:101); and the VH of the anti-WTA antibody comprises CDR H1 comprising the sequence of SFWMH (SEQ ID NO:102), CDR H2 comprising the sequence of FTNNEGTTTAYADSVRG (SEQ ID NO:103), and CDR H3 comprising the sequence of GEGGLDD (SEQ ID NO:118) or GDGGLDD (SEQ ID NO:104); or (b) the VL of the anti-WTA monoclonal antibody comprises CDR L1 comprising the sequence of RASQTISGWLA (SEQ ID NO:33), CDR L2 comprising the sequence of KASTLES (SEQ ID NO:34), and CDR L3 comprising the sequence of QQYKSYSFN (SEQ ID NO:35); and the VH of the anti-WTA antibody comprises CDR H1 comprising the sequence of SYDIN (SEQ ID NO:36), CDR H2 comprising the sequence of WMNANSGNTGYAQKFQG (SEQ ID NO:37), and CDR H3 comprising the sequence of SSILVRGALGRYFDL (SEQ ID NO:38). Ab is the anti-wall teichoic acid antibody; L is the peptide linker having the formula: -Str-Pep-Y- where Str is a stretcher unit; Pep is a peptide of two to twelve amino acid residues, and Y is a spacer unit; abx is the antibiotic moiety; and p is an integer from 1 to 8;