A compound as represented by Formula I: or a pharmaceutically acceptable salt thereof, wherein Each R x is independently H, halo, OR, C 1 -C 6 alkyl, (CR 2) 0-1 CN, OR, C OR 10, C 3 -C 10 cycloalkyl, NR 6 C R 10, NR 6 SO 2 R 8, or NH 2, said alkyl and cycloalkyl are optionally substituted with 1 to 3 substituents selected from halo, OR and C 1 -C 6 alkyl; Each R is independently H, C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl, said alkyl and cycloalkyl are optionally substituted with 1 to 4 halo substituents; Each R a is independently H, C 1 -C 6 alkyl, aryl or CF 3, said alkyl and aryl are optionally substituted with 1 to 3 aryl, CF 3 or halo substituents; R 1 is 1) H, 2) CN, 3) OR, 4) C 1 -C 6 alkyl, 5) C 3 -C 6 cycloalkyl 6) aryl, 7) heteroaryl, 8) heterocyclyl, 9) C R 10, 10) C NRR 6, or 11) C OR 10; wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl are optionally substituted with one to three CF 3, OR, CN, C 1 -C 6 alkyl, or halo substituents; R 2 is 1) H, or 2) C 1 -C 6 alkyl, said alkyl is optionally substituted with one to three OR, CN or halo substituents; R 3 is (CR 2) t -aryl or (CR 2) t -heteroaryl, wherein said aryl and heteroaryl are substituted with one to three R 9; R 4 is - NR 6 S 2 R 8 or - (CR 2) v -S p R 8; Each R 6 is independently H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, heteroaryl or aryl, said alkyl, cycloalkyl, or heteroaryl may be optionally substituted with aryl, heteroaryl or heterocyclyl; Each R 8 is independently C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl or aryl, said alkyl, cycloalkyl and aryl are optionally substituted with 1 to 3 C 3 -C 10 cycloalkyl or halo substituents; Each R 9 is independently halo, CN, OCF 3, C 1 -C 6 alkyl, OR, NH 2, aryl or heteroaryl, where said alkyl, aryl or heteoraryl may be optionally substituted with one to three CN, OCF 3, OR, C 1 -C 6 alkyl, NH 2 or halo substituents; Each R 10 is independently H, C 1 -C 6 alkyl, or aryl, said alkyl is optionally substituted with 1-3 halo; n is 0, 1, 2 or 3; p is 0, 1 or 2; t is 0, 1 or 2; v is 0, 1, 2 or 3; x is 0, 1, 2 or 3. Each R x is independently H, halo, OR, C 1 -C 6 alkyl, (CR 2) 0-1 CN, OR, C OR 10, C 3 -C 10 cycloalkyl, NR 6 C R 10, NR 6 SO 2 R 8, or NH 2, said alkyl and cycloalkyl are optionally substituted with 1 to 3 substituents selected from halo, OR and C 1 -C 6 alkyl; Each R is independently H, C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl, said alkyl and cycloalkyl are optionally substituted with 1 to 4 halo substituents; Each R a is independently H, C 1 -C 6 alkyl, aryl or CF 3, said alkyl and aryl are optionally substituted with 1 to 3 aryl, CF 3 or halo substituents; R 1 is 1) H, 2) CN, 3) OR, 4) C 1 -C 6 alkyl, 5) C 3 -C 6 cycloalkyl 6) aryl, 7) heteroaryl, 8) heterocyclyl, 9) C R 10, 10) C NRR 6, or 11) C OR 10; 1) H, 2) CN, 3) OR, 4) C 1 -C 6 alkyl, 5) C 3 -C 6 cycloalkyl 6) aryl, 7) heteroaryl, 8) heterocyclyl, 9) C R 10, 10) C NRR 6, or 11) C OR 10; wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl are optionally substituted with one to three CF 3, OR, CN, C 1 -C 6 alkyl, or halo substituents; R 2 is 1) H, or 2) C 1 -C 6 alkyl, said alkyl is optionally substituted with one to three OR, CN or halo substituents; 1) H, or 2) C 1 -C 6 alkyl, said alkyl is optionally substituted with one to three OR, CN or halo substituents; R 3 is (CR 2) t -aryl or (CR 2) t -heteroaryl, wherein said aryl and heteroaryl are substituted with one to three R 9; R 4 is - NR 6 S 2 R 8 or - (CR 2) v -S p R 8; - NR 6 S 2 R 8 or - (CR 2) v -S p R 8; Each R 6 is independently H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, heteroaryl or aryl, said alkyl, cycloalkyl, or heteroaryl may be optionally substituted with aryl, heteroaryl or heterocyclyl; Each R 8 is independently C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl or aryl, said alkyl, cycloalkyl and aryl are optionally substituted with 1 to 3 C 3 -C 10 cycloalkyl or halo substituents; Each R 9 is independently halo, CN, OCF 3, C 1 -C 6 alkyl, OR, NH 2, aryl or heteroaryl, where said alkyl, aryl or heteoraryl may be optionally substituted with one to three CN, OCF 3, OR, C 1 -C 6 alkyl, NH 2 or halo substituents; Each R 10 is independently H, C 1 -C 6 alkyl, or aryl, said alkyl is optionally substituted with 1-3 halo; n is 0, 1, 2 or 3; p is 0, 1 or 2; t is 0, 1 or 2; v is 0, 1, 2 or 3; x is 0, 1, 2 or 3.