A system for determining target heart ablation regions, the system comprising: a plurality of sensors (208, 210) configured to detect a plurality of electro-cardiogram signals each indicating electrical activity of a heart over time, each of the plurality of sensors configured to detect one of the ECG signals; a processing device comprising one or more processors configured to: determine, for each of the plurality of ECG signals, a plurality of local activation times (LATs) occurring over time, each LAT indicating a time of electrical activation for an area the heart; generate, based on the determined plurality of LATs of each of the plurality of ECG signals, mapping information for one or more maps representing the electrical activity of the heart; and determine a region of interest of the heart by identifying the ROI as a region of the heart exhibiting conditions indicative of cardiac arrhythmia based on the generated mapping information for the one or more maps representing the electrical activity of the heart, wherein the ROI is identified as exhibiting conditions indicative of atrial fibrillation, wherein generated mapping information for the one or more generated maps representing the electrical activity of the heart comprises generating driver mapping information indicating potential AF drivers of AF, and wherein the driver mapping information is generated according to time intervals between the LATs, information indicating earliness of the LATs and ratios of amplitudes of R-waves of the ECG signals and amplitudes of S-waves of the ECG signals. a plurality of sensors (208, 210) configured to detect a plurality of electro-cardiogram signals each indicating electrical activity of a heart over time, each of the plurality of sensors configured to detect one of the ECG signals; a processing device comprising one or more processors configured to: determine, for each of the plurality of ECG signals, a plurality of local activation times (LATs) occurring over time, each LAT indicating a time of electrical activation for an area the heart; generate, based on the determined plurality of LATs of each of the plurality of ECG signals, mapping information for one or more maps representing the electrical activity of the heart; and determine a region of interest of the heart by identifying the ROI as a region of the heart exhibiting conditions indicative of cardiac arrhythmia based on the generated mapping information for the one or more maps representing the electrical activity of the heart, wherein the ROI is identified as exhibiting conditions indicative of atrial fibrillation, wherein generated mapping information for the one or more generated maps representing the electrical activity of the heart comprises generating driver mapping information indicating potential AF drivers of AF, and wherein the driver mapping information is generated according to time intervals between the LATs, information indicating earliness of the LATs and ratios of amplitudes of R-waves of the ECG signals and amplitudes of S-waves of the ECG signals. determine, for each of the plurality of ECG signals, a plurality of local activation times (LATs) occurring over time, each LAT indicating a time of electrical activation for an area the heart; generate, based on the determined plurality of LATs of each of the plurality of ECG signals, mapping information for one or more maps representing the electrical activity of the heart; and determine a region of interest of the heart by identifying the ROI as a region of the heart exhibiting conditions indicative of cardiac arrhythmia based on the generated mapping information for the one or more maps representing the electrical activity of the heart, wherein the ROI is identified as exhibiting conditions indicative of atrial fibrillation, wherein generated mapping information for the one or more generated maps representing the electrical activity of the heart comprises generating driver mapping information indicating potential AF drivers of AF, and wherein the driver mapping information is generated according to time intervals between the LATs, information indicating earliness of the LATs and ratios of amplitudes of R-waves of the ECG signals and amplitudes of S-waves of the ECG signals.