A method for purifying a target molecule, comprising: a) in a vessel, providing a support to a liquid mixture comprising contents of a destabilized droplet that comprise a target molecule, wherein said support binds said target molecule to provide a bound target molecule; b) positioning said vessel in a first vessel receptacle of a magnetic separation device comprising: i) said first vessel receptacle disposed on a first face of said magnetic separation device, wherein said first vessel receptacle is configured to position a vessel relative to a first magnetic source, which first magnetic source provides a magnetic field that immobilizes said support at a first location within said vessel, wherein said magnetic separation device is at a first orientation; and ii) a second vessel receptacle disposed on a second face of said magnetic separation device, wherein said second vessel receptacle is configured to position said vessel relative to a second magnetic source; c) while said support is immobilized at said first location, removing said liquid mixture from said vessel; d) providing a suspension fluid to said vessel, thereby suspending said support in said suspension fluid; e) moving said magnetic separation device from said first orientation to a second orientation different from said first orientation; f) positioning said vessel in said second vessel receptacle such that said second magnetic source provides a magnetic field that immobilizes said support at a second location within said vessel, wherein said magnetic separation device is at said second orientation; wherein said second location within said vessel is different than said first location within said vessel, said second face of said magnetic separation device is different from said first face of said magnetic separation device, and said second vessel receptacle of said magnetic separation device is different from said first vessel receptacle of said magnetic separation device; and g) while said support is immobilized at said second location, removing said suspension fluid. a) in a vessel, providing a support to a liquid mixture comprising contents of a destabilized droplet that comprise a target molecule, wherein said support binds said target molecule to provide a bound target molecule; b) positioning said vessel in a first vessel receptacle of a magnetic separation device comprising: i) said first vessel receptacle disposed on a first face of said magnetic separation device, wherein said first vessel receptacle is configured to position a vessel relative to a first magnetic source, which first magnetic source provides a magnetic field that immobilizes said support at a first location within said vessel, wherein said magnetic separation device is at a first orientation; and ii) a second vessel receptacle disposed on a second face of said magnetic separation device, wherein said second vessel receptacle is configured to position said vessel relative to a second magnetic source; i) said first vessel receptacle disposed on a first face of said magnetic separation device, wherein said first vessel receptacle is configured to position a vessel relative to a first magnetic source, which first magnetic source provides a magnetic field that immobilizes said support at a first location within said vessel, wherein said magnetic separation device is at a first orientation; and ii) a second vessel receptacle disposed on a second face of said magnetic separation device, wherein said second vessel receptacle is configured to position said vessel relative to a second magnetic source; c) while said support is immobilized at said first location, removing said liquid mixture from said vessel; d) providing a suspension fluid to said vessel, thereby suspending said support in said suspension fluid; e) moving said magnetic separation device from said first orientation to a second orientation different from said first orientation; f) positioning said vessel in said second vessel receptacle such that said second magnetic source provides a magnetic field that immobilizes said support at a second location within said vessel, wherein said magnetic separation device is at said second orientation; wherein said second location within said vessel is different than said first location within said vessel, said second face of said magnetic separation device is different from said first face of said magnetic separation device, and said second vessel receptacle of said magnetic separation device is different from said first vessel receptacle of said magnetic separation device; and g) while said support is immobilized at said second location, removing said suspension fluid.