A medical imaging system comprising: an X-ray source operative to transmit X-rays through a subject; a detector operative to receive the X-ray energy of the X-rays after having passed through the subject; and a processing system programmed to: generate a pre-shot image of the subject using low energy X-ray intensity from the X-ray source; determine a plurality of acquisition parameters for a main scan of the subject based on the pre-shot image; determine a saturation time of the detector corresponding to the plurality of acquisition parameters based on detector calibration data, wherein the detector calibration data is predetermined in advance of the main scan and wherein the processing system is programmed to determine the detector calibration data by illuminating the detector without the subject in a plurality of configuration settings of the medical imaging system and recording the saturation time for each of the plurality of configuration settings in a look up table; determine a number of time frames required to reach a targeted dose based on the saturation time; apply an X-ray dosage level of the subject using the X-ray source based on the number of time frames; and generate an image of the subject based on the detected X-ray energy at the X-ray detector for the applied X-ray dosage level. an X-ray source operative to transmit X-rays through a subject; a detector operative to receive the X-ray energy of the X-rays after having passed through the subject; and a processing system programmed to: generate a pre-shot image of the subject using low energy X-ray intensity from the X-ray source; determine a plurality of acquisition parameters for a main scan of the subject based on the pre-shot image; determine a saturation time of the detector corresponding to the plurality of acquisition parameters based on detector calibration data, wherein the detector calibration data is predetermined in advance of the main scan and wherein the processing system is programmed to determine the detector calibration data by illuminating the detector without the subject in a plurality of configuration settings of the medical imaging system and recording the saturation time for each of the plurality of configuration settings in a look up table; determine a number of time frames required to reach a targeted dose based on the saturation time; apply an X-ray dosage level of the subject using the X-ray source based on the number of time frames; and generate an image of the subject based on the detected X-ray energy at the X-ray detector for the applied X-ray dosage level. generate a pre-shot image of the subject using low energy X-ray intensity from the X-ray source; determine a plurality of acquisition parameters for a main scan of the subject based on the pre-shot image; determine a saturation time of the detector corresponding to the plurality of acquisition parameters based on detector calibration data, wherein the detector calibration data is predetermined in advance of the main scan and wherein the processing system is programmed to determine the detector calibration data by illuminating the detector without the subject in a plurality of configuration settings of the medical imaging system and recording the saturation time for each of the plurality of configuration settings in a look up table; determine a number of time frames required to reach a targeted dose based on the saturation time; apply an X-ray dosage level of the subject using the X-ray source based on the number of time frames; and generate an image of the subject based on the detected X-ray energy at the X-ray detector for the applied X-ray dosage level.