A compound having the Formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A is a 5,6-fused bicyclic heteroaryl comprising 1 or 2 nitrogen atoms and optionally substituted with 1 to 3 groups selected from R a; Ring B is phenyl, 5-6 membered heteroaryl, 9-10 membered heteroaryl, or 5-6 membered heterocyclyl, each optionally substituted with 1 to 3 groups selected from R b; R 1 is C 1-6 alkyl, aryl, cycloalkyl, or heteroaryl, wherein each of said aryl, cycloalkyl, and heteroaryl are optionally substituted with 1 to 3 groups selected from R c C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, -C 1-6 alkylOR c, -C 1-6 alkylN(R d) 2, -C 1-6 alkylC OR d, -C 1-6 alkylOC 1-6 alkylN(R d) 2, -C 1-6 alkylSOR d, -C 1-6 alkylS 2 R d, -C 1-6 alkylSON(R d) 2, -C 1-6 alkylSO 2 N(R d) 2, -C 1-6 alkylcycloalkyl, -C 1-6 alkylheterocyclyl, -C 1-6 alkylheteroaryl, -C 1-6 alkylaryl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein each of said cycloalkyl, heterocyclyl, aryl, and heteroaryl alone and in connection with -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, and -C 1-6 alkylheterocyclyl are optionally substituted with 1 to 3 groups selected from R c; R 2 is hydrogen or C 1-4 alkyl; R 3 is hydrogen; R 4 is hydrogen or C 1-4 alkyl; R 5 is hydrogen; each of R a, R b, and R c are each independently halo, CN, oxo, NO 2, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 haloalkyl, -C 1-6 alkylOR d, -C R d, -C OR d, -C 1-6 alkylC OR d, -C N(R d) 2, -C NR d C 1-6 alkylOR d, -OC 1-6 alkylN(R d) 2, -C 1-6 alkylC N(R d) 2, -C 1-6 alkylN(R d) 2, -N(R d) 2, -C NR d C 1-6 alkylN(R d) 2, -NR d C 1-6 alkylN(R d) 2, -NR d C 1-6 alkylOR d, -SOR d, -S 2 R d, -SON(R d) 2, -SO 2 N(R d) 2, SF 5, - Ocycloalkyl, -O-C 1-4 alkylaryl, -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, -C 1-6 alkylheterocyclyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl, wherein each of said cycloalkyl, heterocyclyl, aryl, and heteroaryl alone and in connection with -Ocycloalkyl, -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, and -C 1-6 alkylheterocyclyl are optionally substituted with 1 to 3 groups selected from halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -N(R d) 2, -C R d, and -C 1-6 alkylOR d; and each R d is independently hydrogen, C 1-6 haloalkyl, or C 1-6 alkyl; provided the compound is not 4-(2-((2-(1H-indol-3-yl)-2-oxo-1-phenylethyl)amino)ethyl)benzenesulfonamide; 4-[2-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]ethyl]benzenesulfonamide; 2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-1-(1H-indol-3-yl)-2-phenylethanone, or a salt thereof. Ring A is a 5,6-fused bicyclic heteroaryl comprising 1 or 2 nitrogen atoms and optionally substituted with 1 to 3 groups selected from R a; Ring B is phenyl, 5-6 membered heteroaryl, 9-10 membered heteroaryl, or 5-6 membered heterocyclyl, each optionally substituted with 1 to 3 groups selected from R b; R 1 is C 1-6 alkyl, aryl, cycloalkyl, or heteroaryl, wherein each of said aryl, cycloalkyl, and heteroaryl are optionally substituted with 1 to 3 groups selected from R c C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, -C 1-6 alkylOR c, -C 1-6 alkylN(R d) 2, -C 1-6 alkylC OR d, -C 1-6 alkylOC 1-6 alkylN(R d) 2, -C 1-6 alkylSOR d, -C 1-6 alkylS 2 R d, -C 1-6 alkylSON(R d) 2, -C 1-6 alkylSO 2 N(R d) 2, -C 1-6 alkylcycloalkyl, -C 1-6 alkylheterocyclyl, -C 1-6 alkylheteroaryl, -C 1-6 alkylaryl, cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein each of said cycloalkyl, heterocyclyl, aryl, and heteroaryl alone and in connection with -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, and -C 1-6 alkylheterocyclyl are optionally substituted with 1 to 3 groups selected from R c; R 2 is hydrogen or C 1-4 alkyl; R 3 is hydrogen; R 4 is hydrogen or C 1-4 alkyl; R 3 is hydrogen; R 4 is hydrogen or C 1-4 alkyl; R 5 is hydrogen; each of R a, R b, and R c are each independently halo, CN, oxo, NO 2, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 haloalkyl, -C 1-6 alkylOR d, -C R d, -C OR d, -C 1-6 alkylC OR d, -C N(R d) 2, -C NR d C 1-6 alkylOR d, -OC 1-6 alkylN(R d) 2, -C 1-6 alkylC N(R d) 2, -C 1-6 alkylN(R d) 2, -N(R d) 2, -C NR d C 1-6 alkylN(R d) 2, -NR d C 1-6 alkylN(R d) 2, -NR d C 1-6 alkylOR d, -SOR d, -S 2 R d, -SON(R d) 2, -SO 2 N(R d) 2, SF 5, - Ocycloalkyl, -O-C 1-4 alkylaryl, -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, -C 1-6 alkylheterocyclyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl, wherein each of said cycloalkyl, heterocyclyl, aryl, and heteroaryl alone and in connection with -Ocycloalkyl, -C 1-6 alkylcycloalkyl, -C 1-6 alkylaryl, -C 1-6 alkylheteroaryl, and -C 1-6 alkylheterocyclyl are optionally substituted with 1 to 3 groups selected from halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -N(R d) 2, -C R d, and -C 1-6 alkylOR d; and each R d is independently hydrogen, C 1-6 haloalkyl, or C 1-6 alkyl; provided the compound is not 4-(2-((2-(1H-indol-3-yl)-2-oxo-1-phenylethyl)amino)ethyl)benzenesulfonamide; 4-[2-[[2-(7-ethyl-1H-indol-3-yl)-2-oxo-1-phenylethyl]amino]ethyl]benzenesulfonamide; 2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-1-(1H-indol-3-yl)-2-phenylethanone, or a salt thereof.