An article of footwear comprising: an upper including a throat closure integrally forming a tongue portion and defining a portion of an interior void; a first cable portion movable in a first tightening direction to move the upper into a tightened state and movable in a first loosening direction to move the upper into a loosened state; a second cable portion movable in a second tightening direction when the first cable portion is moved in the first tightening direction and movable in a second loosening direction when the first cable portion is moved in the first loosening direction; a cable lock operable in a locked state to restrict movement of the first cable portion in the first loosening direction and the second cable portion in the second loosening direction and operable in an unlocked state to permit movement of the first cable portion in the first loosening direction and the second cable portion in the second loosening direction; a series of first cable guides attached to the upper on a medial side and extending along the throat closure and receiving the first cable portion, the first cable guides each including a first convex inner surface operable to engage and direct movement of the first cable portion relative to the upper; and a series of second cable guides attached to the upper on a lateral side and extending along the throat closure and receiving the first cable portion, the second cable guides each including a second convex inner surface operable to engage and direct movement of the first cable portion relative to the upper, wherein the second cable portion is a continuous loop extending from the cable lock around a tongue portion proximate to where an ankle opening and the throat closure meet. an upper including a throat closure integrally forming a tongue portion and defining a portion of an interior void; a first cable portion movable in a first tightening direction to move the upper into a tightened state and movable in a first loosening direction to move the upper into a loosened state; a second cable portion movable in a second tightening direction when the first cable portion is moved in the first tightening direction and movable in a second loosening direction when the first cable portion is moved in the first loosening direction; a cable lock operable in a locked state to restrict movement of the first cable portion in the first loosening direction and the second cable portion in the second loosening direction and operable in an unlocked state to permit movement of the first cable portion in the first loosening direction and the second cable portion in the second loosening direction; a series of first cable guides attached to the upper on a medial side and extending along the throat closure and receiving the first cable portion, the first cable guides each including a first convex inner surface operable to engage and direct movement of the first cable portion relative to the upper; and a series of second cable guides attached to the upper on a lateral side and extending along the throat closure and receiving the first cable portion, the second cable guides each including a second convex inner surface operable to engage and direct movement of the first cable portion relative to the upper, wherein the second cable portion is a continuous loop extending from the cable lock around a tongue portion proximate to where an ankle opening and the throat closure meet.