mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising at least one DPP4 inhibitor of formula wherein R 1, R 2, R 4 and R 5 are H, R 3 is benzyl and n is 1 or a dermatologically acceptable salt thereof for use in the prevention or treatment of disorders of the sebaceous glands. wherein R 1, R 2, R 4 and R 5 are H, R 3 is benzyl and n is 1 or a dermatologically acceptable salt thereof for use in the prevention or treatment of disorders of the sebaceous glands.
A method for authenticating a first device, the method executed by a server, the server comprising a database, the database storing a profile associated to a user of the first device, the server using the profile of the user to generate a first challenge comprising a question about a characteristic of the first device and a corresponding response for authentication of the first device, the server sending the first challenge to the first device, the method comprising, upon receiving a response to the first challenge from the first device that matches the corresponding response generated by the server, the steps of: - granting authentication of the first device; - receiving contextual information from the first device in response to the granted authentication; and - updating the profile associated to the user of the first device with the received contextual information for a subsequent generation of a second challenge comprising a second question about another characteristic of the first device for authentication of the first device. - granting authentication of the first device; - receiving contextual information from the first device in response to the granted authentication; and - updating the profile associated to the user of the first device with the received contextual information for a subsequent generation of a second challenge comprising a second question about another characteristic of the first device for authentication of the first device.
A peptide comprising a hydrophobic part and a hydrophilic part, wherein the hydrophilic part comprises a positively charged amino acid residue, wherein the peptide is CH 3 (CH 2) 16 CONH-B-CONH 2 and B is H16R8.
A brake disc for a disc brake device, having a disc body comprising a central hub and a wall surrounding the central hub, wherein the wall surrounding the central hub includes: - an outer circumferential portion with two opposite faces defining two annular crown surfaces constituting the braking surfaces of the disc, and - an intermediate circumferential portion, radially interposed between the hub and the outer circumferential portion defining the braking surfaces, wherein at said intermediate circumferential portion, a plurality of radial blades are formed in one piece with the brake disc, and a plurality of disc ventilating through-openings are formed alternated with the radial blades, said brake disc being characterized in that said outer circumferential portion is a solid-wall portion, said through-openings alternated with the radial blades extending only through said intermediate circumferential portion, and in that, in a front view of the disc, the side edges of two adjacent blades that face the same through-opening are spaced apart from each other in the circumferential direction, so that two radial blades adjacent to each other do not appear to be partially overlapped with each other. - an outer circumferential portion with two opposite faces defining two annular crown surfaces constituting the braking surfaces of the disc, and - an intermediate circumferential portion, radially interposed between the hub and the outer circumferential portion defining the braking surfaces,
An arenavirus particle for use in a method for treating a neoplastic disease in a subject, wherein the method comprises administering to the subject said arenavirus particle and an immune checkpoint inhibitor, wherein said arenavirus particle is a tri-segmented arenavirus particle comprising one L segment and two S segments, and wherein said arenavirus particle is engineered to contain an arenavirus genomic segment comprising: (i) a nucleotide sequence encoding a tumor antigen, tumor associated antigen or an antigenic fragment thereof; and (ii) at least one arenavirus open reading frame ("ORF") in a position other than the wild-type position of said ORF, wherein said ORF encodes the glycoprotein ("GP"), the nucleoprotein ("NP"), the matrix protein Z ("Z protein") or the RNA dependent RNA polymerase L ("L protein") of said arenavirus particle. (i) a nucleotide sequence encoding a tumor antigen, tumor associated antigen or an antigenic fragment thereof; and (ii) at least one arenavirus open reading frame ("ORF") in a position other than the wild-type position of said ORF, wherein said ORF encodes the glycoprotein ("GP"), the nucleoprotein ("NP"), the matrix protein Z ("Z protein") or the RNA dependent RNA polymerase L ("L protein") of said arenavirus particle.
Device (13, 20, 30, 40, 50, 60, 70, 80) for pressing a first transmission element against a second transmission element which engages in the first transmission element, for a rack-and-pinion steering system of a motor vehicle, having a housing, a pressure element (21, 31, 51, 61, 71) and at least one spring element (25, 35, 41, 53, 64, 72, 73, 75), wherein the pressure element (21, 31, 51, 61, 71) can be loaded in the direction of the first transmission element by the spring element (25, 35, 41, 53, 64, 72, 73, 75) and is guided in a displaceable fashion in the housing, characterized in that the spring element (25, 35, 41, 53, 64, 72, 73, 75) is fabricated from at least one dilatant elastic with a modulus of elasticity having a loss modulus and a storage modulus, wherein the characteristic curves (G", G') of the loss modulus and of the storage modulus intersect at an intersection point, with the result that in the case of a low steering changeover frequency the part of a characteristic curve (G") of the loss modulus which is to the left of the intersection point comes into play, and in the case of a high steering changeover frequency the part of a characteristic curve (G') of the storage modulus which is to the right of the intersection point comes into play.
A gyrational crusher, comprising: a stationary bowl; a head assembly positioned for movement within the stationary bowl to create a crushing gap between the stationary bowl and the head assembly; a main shaft having a top end and an outer surface, wherein the head assembly gyrates relative to the main shaft; an eccentric rotatable about the main shaft to impart gyrational movement to the head assembly within the bowl; and a socket mounted to the top end of the main shaft; characterized in that it further comprises a hydraulic separation system including at least one hydraulic groove (64, 66) positioned between the main shaft and the socket and operable to separate the socket from the top end of the main shaft. a stationary bowl; a head assembly positioned for movement within the stationary bowl to create a crushing gap between the stationary bowl and the head assembly; a main shaft having a top end and an outer surface, wherein the head assembly gyrates relative to the main shaft; an eccentric rotatable about the main shaft to impart gyrational movement to the head assembly within the bowl; and a socket mounted to the top end of the main shaft; characterized in that it further comprises a hydraulic separation system including at least one hydraulic groove (64, 66) positioned between the main shaft and the socket and operable to separate the socket from the top end of the main shaft.
Device for connecting at least two elements (22, 23, 24), with an outer part, with an inner part which is displaceable relative to the outer part in a longitudinal direction and on which a radially outwardly directed inner-part toothed structure is formed, with rear grip arms (20, 21) for gripping behind an element and with a cover arrangement opposite to the rear grip arms (20, 21), wherein the cover arrangement is solely formed on a head sleeve of the outer part, wherein the rear grip arms (20, 21) are formed on the inner part, wherein the outer part for each rear grip arm (20, 21) comprises a wall clearance (7, 8) through which the respective rear grip arm (20, 21) grips, and wherein the outer part comprises a radially inwardly directed outer-part toothed structure which is in engagement with the inner-part toothed structure in a final mounting arrangement, characterized in that the inner part comprises a mounting-tool engagement sleeve which has an engagement structure which is resistant up to a predetermined pull-out force.
Process for treating mineral fillers in order to give them a hydrophobic character making them suitable for incorporation in polymers by means of which the so-called "breathable" films, in particular polyolefin films, are produced, characterized in that a surface treatment of the filler is carried out in two separated steps in time: the first step (pre-treatment) comprising treatment with at least one polydialkylsiloxane and the second step comprising treatment with at least one fatty acid comprising more than 10 carbons and characterized in that fillers such as marble and calcite or a mixture thereof, precipitated calcium carbonate, talc, kaolin, magnesium hydroxide, clay, silica, alumina, barium sulfate, mica, calcium oxide, aluminium oxide and mixtures thereof are treated.
A computer-implemented method for iterative branching structure segmentation, comprising: receiving an image representing a branching structure; determining a starting feature of the branching structure; selecting a subregion of the image based on the starting feature; segmenting the branching structure in the subregion; generating a set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246) based on the segmented branching structure, wherein: the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246) indicates where the branching structure in the image continues beyond the subregion (204, 208, 214, 220, 222, 226, 228, 232, 238, 240, 248, 250, 252); and a neural network analyzes the segmented branching structure to determine the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246); and for each of the next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246), repeating the selecting of the subregion (204, 208, 214, 220, 222, 226, 228, 232, 238, 240, 248, 250, 252) based on the next feature, the segmenting of the branching structure, and the generating of the set of next features. receiving an image representing a branching structure; determining a starting feature of the branching structure; selecting a subregion of the image based on the starting feature; segmenting the branching structure in the subregion; generating a set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246) based on the segmented branching structure, wherein: the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246) indicates where the branching structure in the image continues beyond the subregion (204, 208, 214, 220, 222, 226, 228, 232, 238, 240, 248, 250, 252); and a neural network analyzes the segmented branching structure to determine the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246); and the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246) indicates where the branching structure in the image continues beyond the subregion (204, 208, 214, 220, 222, 226, 228, 232, 238, 240, 248, 250, 252); and a neural network analyzes the segmented branching structure to determine the set of next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246); for each of the next features (206, 210-212, 216-218, 224, 230, 234-236, 242-246), repeating the selecting of the subregion (204, 208, 214, 220, 222, 226, 228, 232, 238, 240, 248, 250, 252) based on the next feature, the segmenting of the branching structure, and the generating of the set of next features.
A transceiver configuration method for an access point, applied to the Internet of Things, wherein a frequency band of the Internet of Things is divided into multiple sub-channel combinations comprising any combination of a 1-MHz sub-channel, a 2-MHz sub-channel, a 4-MHz sub-channel, and an 8-MHz sub-channel, and the Internet of Things corresponding to the access point comprises N terminals STA i s, wherein 1≤ i ≤ N and N is a positive integer greater than 1; and the method comprises: for any STA i in the Internet of Things corresponding to the access point, obtaining, by the access point according to received signal quality information of the STA i, a maximum data transfer rate R i ( n) of the STA i on each sub-channel n in a specified sub-channel combination; and obtaining, according to an average data volume needing to be sent by the STA i within a beacon period and R i ( n), a channel access time T i ( n) required by the STA i on the sub-channel n; determining, by the access point according to an available access time T available ( n) of each sub-channel n within the beacon period and T i ( n) of the N STA i s, whether the specified sub-channel combination meets an allocation requirement of the N STA i s; and when the access point determines that the specified sub-channel combination meets the allocation requirement of the N STA i s, configuring at least one transceiver on each sub-channel n in the specified sub-channel combination, wherein n =1 indicates an 8-MHz sub-channel; n =2 and n =3 indicate two 4-MHz sub-channels; n =4, n =5, n =6, and n =7 indicate four 2-MHz sub-channels; n =8, n =9,..., and n =15 indicate eight 1-MHz sub-channels. for any STA i in the Internet of Things corresponding to the access point, obtaining, by the access point according to received signal quality information of the STA i, a maximum data transfer rate R i ( n) of the STA i on each sub-channel n in a specified sub-channel combination; and obtaining, according to an average data volume needing to be sent by the STA i within a beacon period and R i ( n), a channel access time T i ( n) required by the STA i on the sub-channel n; determining, by the access point according to an available access time T available ( n) of each sub-channel n within the beacon period and T i ( n) of the N STA i s, whether the specified sub-channel combination meets an allocation requirement of the N STA i s; and when the access point determines that the specified sub-channel combination meets the allocation requirement of the N STA i s, configuring at least one transceiver on each sub-channel n in the specified sub-channel combination, wherein n =1 indicates an 8-MHz sub-channel; n =2 and n =3 indicate two 4-MHz sub-channels; n =4, n =5, n =6, and n =7 indicate four 2-MHz sub-channels; n =8, n =9,..., and n =15 indicate eight 1-MHz sub-channels.
A method of operating a mobile receiver in a mobile communication system, wherein the mobile communication system comprises first and second nodes, wherein the first node transmits common control signals and the second node transmits dedicated data signals, the method is characterised by determining a first timing of the common control signals and a second timing of the dedicated data signals, and/or a first frequency of the common control signals and a second frequency of the dedicated data signals; determining at least one of a first difference and a second difference, wherein the first difference is a difference between the first timing of the common control signals and the second timing of the dedicated data signals and the second difference is a difference between the first frequency of the common control signals and the second frequency of the dedicated data signals; producing an adapted timing of dedicated data signals based on at least one of the first and second differences; and using (413, 415) the adapted timing to receive dedicated data signals.
A device for actuating a discharge valve of a WC flush tank, having at least one pushbutton (23, 25, 26; 81), upon manual press-actuation of which the discharge valve moves into an open position in which a volume of flushing water can flow out of the discharge fitting of the WC flush tank, wherein the device has at least one control valve, which can be actuated with the pushbutton (23, 25, 26; 81) and which is arranged in a control line connected to a water supply network, wherein upon manual press-actuation of the pushbutton (23, 25, 26; 81), a water volume flow (m), with which the discharge valve can be activated, can be adjusted by means of the control valve, wherein the control valve has a lift-adjustable control piston in a valve housing, which can be adjusted by means of at least one user-operated pushbutton (23, 25, 26; 81) and which is spring-tensioned into a closed position, in which a control piston valve plate is in sealing contact with a valve seat fixed to the housing and closes a flow path through the control valve, and which control piston is moved into its open position along a button travel path (h 1, h 2, h 3) against the spring-tensioning force when the pushbutton (23, 25, 26; 81) is press-actuated, in which position the flow path through the control valve is unblocked, and is reset to its closed position under the action of the spring-tensioning force when the pressure on the pushbutton (23, 25, 26; 81) is released, characterized in that the device furthermore has a vacuum unit and that the length of the button travel path (h 1, h 2, h 3) correlates with the length of a reset time interval, within which the control piston is reset to its closed position after the pressure on the pushbutton is released, wherein within the reset time interval the water volume flow (m) passes through the vacuum unit and a vacuum is generated.
A method for manufacturing a linear lighting device, said method comprising the steps of: providing a sheet of optically transmissive material, a sheet of thermally conductive material, and a plurality of light sources, arranging the light sources on the sheet of thermally conductive material, roll forming the sheet of thermally conductive material into a supporting heat spreader profile, roll forming the sheet of optically transmissive material into a first shape to cover said light sources and define an optical chamber, attaching end portions of said sheet of optically transmissive material to said supporting heat spreader profile. providing a sheet of optically transmissive material, a sheet of thermally conductive material, and a plurality of light sources, arranging the light sources on the sheet of thermally conductive material, roll forming the sheet of thermally conductive material into a supporting heat spreader profile, roll forming the sheet of optically transmissive material into a first shape to cover said light sources and define an optical chamber, attaching end portions of said sheet of optically transmissive material to said supporting heat spreader profile.
An electrostatic printer comprising: a photoconductor member; a charging unit to charge the photoconductor member to a charged voltage; an imaging unit to generate a latent electrostatic image on the photoconductor member by discharging areas of the charged photoconductor member; a developer unit to develop a toner image on the photoconductor member using a developer voltage (V dev); and characterised in that the electrostatic printer further comprises: a controller to: perform a developer voltage calibration to obtain a desired toner layer thickness; change the developer voltage (V dev) based on the developer voltage calibration, and change the charged voltage (V dark) dependent on the change of the developer voltage (V dev), wherein the rate of changing the charged voltage (V dark) depends on the value of the developer voltage (V dev). a photoconductor member; a charging unit to charge the photoconductor member to a charged voltage; an imaging unit to generate a latent electrostatic image on the photoconductor member by discharging areas of the charged photoconductor member; a developer unit to develop a toner image on the photoconductor member using a developer voltage (V dev); and characterised in that the electrostatic printer further comprises: a controller to: perform a developer voltage calibration to obtain a desired toner layer thickness; change the developer voltage (V dev) based on the developer voltage calibration, and change the charged voltage (V dark) dependent on the change of the developer voltage (V dev), wherein the rate of changing the charged voltage (V dark) depends on the value of the developer voltage (V dev). perform a developer voltage calibration to obtain a desired toner layer thickness; change the developer voltage (V dev) based on the developer voltage calibration, and change the charged voltage (V dark) dependent on the change of the developer voltage (V dev), wherein the rate of changing the charged voltage (V dark) depends on the value of the developer voltage (V dev).
A method for one-pot one-step assembly of two or more DNA molecules to form at least one recombinant DNA molecule, wherein the two or more DNA molecules to be assembled are respectively flanked by type IIs restriction endonuclease cleavage sites with opposite orientations and are brought together with a suitable reaction medium in a reaction vessel, characterized in that the two or more DNA molecules to be assembled are present in dry form on or in at least one substrate which is configured and dimensioned in a manner such that it can be disposed individually as a whole and unchanged in a micro-reaction vessel and is or comprises a piece of filter paper or a cellulose particle.
A method for manufacturing a trochoid pump having a crescent, wherein an inner rotor, which has an inner rotor tooth profile of an almost perfect trochoid shape produced by a first circle (c) which forms the bottomlands of the inner rotor, is formed in advance, with the number of teeth of the inner rotor being set to a predetermined number N that is equal to or larger than 4, in order to manufacture an outer rotor which has an outer rotor tooth profile with a predetermined second number, equal to N plus a natural number equal to or larger than 2, of teeth, a second circle of a diameter smaller than that of the first circle or an ellipse with a short axis less than the diameter of the first circle is disposed so that it is brought into contact with a tooth bottomland of the inner rotor tooth profile, the inner rotor tooth profile is rotated by half a tooth about the center of the inner rotor and the second circle or ellipse is also rotated by half of the predetermined second number of outer rotor teeth about a virtual center (O 1, O 2, O 3) of the outer rotor to form an adjacent second circle or ellipse, an established center (O x) is determined either from the virtual center when the adjacent second circle or ellipse assumes, in the course of the rotation, a state of being in contact, without penetration or separation, with a tooth bottomland or tooth tip zone of the inner rotor tooth profile, or by a mathematical expression from an interval (L, L 1, L 2) between the second circles or ellipses when a contact state is assumed, a reference circle is found that has a radius (r) from the established center to the second circles or ellipses and the total second predetermined number of second circles or ellipses are equidistantly spaced thereon to form outer rotor tooth tips, and the outer rotor tooth profile is thereby manufactured.