mhurhangee/ep-ind-claims huggingface dataset:
A method for sterilizing a medical device by irradiation, comprising: obtaining a first dose map and a second dose map for the medical device based on exposure of the medical device to a nominal dose level of radiation, including the steps of disposing the medical device in a first orientation relative to a radiation source to obtain the first dose map, and disposing the medical device in a second orientation relative to the radiation source to obtain the second dose map; selecting a first dose level and a second dose level based on a distribution of dose levels described by each of the first dose map and the second dose map, wherein the second dose level is different from the first dose level; and sterilizing the medical device including the steps of disposing the medical device in the first orientation and then exposing the medical device to the first dose level and disposing the medical device in the second orientation and then exposing the medical device to the second dose level, wherein a total radiation received at a location on the medical device is the sum total of the radiation received at the location after exposure to the first dose level and the second dose level; wherein the first dose level and the second dose level are selected so that the difference in the total radiation between a first location and a second location is minimized. obtaining a first dose map and a second dose map for the medical device based on exposure of the medical device to a nominal dose level of radiation, including the steps of disposing the medical device in a first orientation relative to a radiation source to obtain the first dose map, and disposing the medical device in a second orientation relative to the radiation source to obtain the second dose map; disposing the medical device in a first orientation relative to a radiation source to obtain the first dose map, and disposing the medical device in a second orientation relative to the radiation source to obtain the second dose map; selecting a first dose level and a second dose level based on a distribution of dose levels described by each of the first dose map and the second dose map, wherein the second dose level is different from the first dose level; and sterilizing the medical device including the steps of disposing the medical device in the first orientation and then exposing the medical device to the first dose level and disposing the medical device in the second orientation and then exposing the medical device to the second dose level, wherein a total radiation received at a location on the medical device is the sum total of the radiation received at the location after exposure to the first dose level and the second dose level;
Packaging for a fluid product comprising - a receptacle defining a containment volume of said cosmetic product and an opening into said containment volume; - a lid suitable to engage with said receptacle to close said opening; - an applicator suitable to withdraw and to dose at least part of said cosmetic product from said containment volume; - a containment and release body arranged in said containment volume and impregnated with said cosmetic product and suitable to be deformed by said applicator so as to release said cosmetic product on said applicator, - characterized in that it comprises - a mover, to move said applicator with respect to said containment and release body and to said lid, defining, while said lid is engaged with said receptacle closing said opening, a raised position in which said applicator is at the maximum distance from the bottom of said receptacle; and at least a lowered position in which the distance of sad applicator from said bottom of said receptacle is less than said maximum distance so that said applicator deforms said containment and release body and withdraws at least part of said cosmetic product. - a receptacle defining a containment volume of said cosmetic product and an opening into said containment volume; - a lid suitable to engage with said receptacle to close said opening; - an applicator suitable to withdraw and to dose at least part of said cosmetic product from said containment volume; - a containment and release body arranged in said containment volume and impregnated with said cosmetic product and suitable to be deformed by said applicator so as to release said cosmetic product on said applicator, - characterized in that it comprises - a mover, to move said applicator with respect to said containment and release body and to said lid, defining, while said lid is engaged with said receptacle closing said opening, a raised position in which said applicator is at the maximum distance from the bottom of said receptacle; and at least a lowered position in which the distance of sad applicator from said bottom of said receptacle is less than said maximum distance so that said applicator deforms said containment and release body and withdraws at least part of said cosmetic product.
A 2-oxopyrrolidine compound for use in the causal treatment or prevention of a disease or condition associated with central nervous system or peripheral nervous system demyelination in a mammal by maintaining the integrity of myelination of axonal cells, the 2-oxopyrrolidine compound having a general formula I: wherein R is hydrogen, hydroxyl or aminomethyl; R' is hydrogen or piperidinocarbonyl group; R" is hydrogen, aminocarbonylalkyl optionally N-substituted with a di(C 1 -C 4)alkylamino-(C 2 -C 4)alkyl group, anilinocarbonylalky optionally mono or disubstituted on the benzene ring with methyl, methoxy, or halogen; benzyl, optionally mono or disubstituted on the benzene ring with methyl, methoxy, or halogen; wherein one or two of R, R' and R" is hydrogen; with the provisos that when R' is other than hydrogen, then R and R" are both hydrogen, and when R is other than hydrogen, then R' is hydrogen, or a pharmaceutically acceptable salt thereof; and in which the disease or condition associated with central nervous system or peripheral nervous system demyelination is multiple sclerosis. wherein R is hydrogen, hydroxyl or aminomethyl; R' is hydrogen or piperidinocarbonyl group; R" is hydrogen, aminocarbonylalkyl optionally N-substituted with a di(C 1 -C 4)alkylamino-(C 2 -C 4)alkyl group, anilinocarbonylalky optionally mono or disubstituted on the benzene ring with methyl, methoxy, or halogen; benzyl, optionally mono or disubstituted on the benzene ring with methyl, methoxy, or halogen; wherein one or two of R, R' and R" is hydrogen; with the provisos that when R' is other than hydrogen, then R and R" are both hydrogen, and when R is other than hydrogen, then R' is hydrogen, or a pharmaceutically acceptable salt thereof; and in which the disease or condition associated with central nervous system or peripheral nervous system demyelination is multiple sclerosis.
A head mounted display comprising: a displaying unit (208, 209) to display an image; an image signal processing unit to process an image signal; a display control unit to perform an image quality adjustment of the image signal processed by the image signal processing unit, and to control a display in the displaying unit; a mounting sensor to detect whether an observer has mounted the apparatus; and a control unit to issue an instruction for the image quality adjustment of the image signal in the display control unit, in response to a detection result by the mounting sensor; characterized by a light shielding hood to shield the eyes of the observer from environmental light, above the displaying unit, such that the light shielding hood shields the eyes of the viewer from environmental light and makes the same situation as being in a dark place, maintaining the viewing environment nearly constant, wherein the control unit lights the displaying unit (208, 209) and issues an instruction for an adjustment of luminance thereof, in response to the mounting sensor detecting that the observer has mounted the apparatus, wherein the control unit issues an instruction for an adjustment of luminance of the displaying unit in accordance with dark adaptation of a luminosity property of an eye of the observer, in response to the mounting sensor detecting that the observer has mounted the apparatus. a displaying unit (208, 209) to display an image; an image signal processing unit to process an image signal; a display control unit to perform an image quality adjustment of the image signal processed by the image signal processing unit, and to control a display in the displaying unit; a mounting sensor to detect whether an observer has mounted the apparatus; and a control unit to issue an instruction for the image quality adjustment of the image signal in the display control unit, in response to a detection result by the mounting sensor; characterized by a light shielding hood to shield the eyes of the observer from environmental light, above the displaying unit, such that the light shielding hood shields the eyes of the viewer from environmental light and makes the same situation as being in a dark place, maintaining the viewing environment nearly constant, wherein the control unit lights the displaying unit (208, 209) and issues an instruction for an adjustment of luminance thereof, in response to the mounting sensor detecting that the observer has mounted the apparatus, wherein the control unit issues an instruction for an adjustment of luminance of the displaying unit in accordance with dark adaptation of a luminosity property of an eye of the observer, in response to the mounting sensor detecting that the observer has mounted the apparatus.
A closure for a container, comprising - a base configured to be attached to a mouth of said container; - a cap comprising a top member and a body member extending from said top member; and - a connecting member comprising a strip of resilient material extending between and connecting said base and said cap, said cap being mobile between a first, closed position wherein said cap is disposed upon said base, and a second, opened position wherein said cap is detached from said base, in which said body member comprises a recess with a first side opening on an edge of said body member opposite the top member, and said connecting member is fastened along a first hinge to a second side of the recess opposite said first side, and in which when said cap is disposed in said first, closed position, said connecting member is accommodated in said recess such that it lies substantially flush with an exterior surface of said body member; and when said cap is disposed in said second, opened position, said connecting member is rotated through at least 90° about said first hinge, the connecting member comprising a plurality of intermediate hinges characterized in that the plurality of intermediate hinges allows to provide rotation of said connecting member over a deflection of at least 270°; and in that the first, second and intermediate hinges (112, 113, 116) are configured in progressively increasing rigidity from the cap to the base. - a base configured to be attached to a mouth of said container; - a cap comprising a top member and a body member extending from said top member; and - a connecting member comprising a strip of resilient material extending between and connecting said base and said cap, said cap being mobile between a first, closed position wherein said cap is disposed upon said base, and a second, opened position wherein said cap is detached from said base, in which said body member comprises a recess with a first side opening on an edge of said body member opposite the top member, and said connecting member is fastened along a first hinge to a second side of the recess opposite said first side, and in which when said cap is disposed in said first, closed position, said connecting member is accommodated in said recess such that it lies substantially flush with an exterior surface of said body member; and when said cap is disposed in said second, opened position, said connecting member is rotated through at least 90° about said first hinge, the connecting member comprising a plurality of intermediate hinges characterized in that the plurality of intermediate hinges allows to provide rotation of said connecting member over a deflection of at least 270°; and in that the first, second and intermediate hinges (112, 113, 116) are configured in progressively increasing rigidity from the cap to the base.
System for estimating the state of charge of a battery comprising at least two modules (1, 2, 3, 4) each provided with at least one cell (13-18, 19-24, 25-30, 31-36), said system including a sensor of the series current flowing through all the cells of the modules connected in series, characterized in that it further includes: - switching means capable of selectively disconnecting one of the modules, the other modules remaining connected in series; and - a calculation means configured for calculating the state of charge of the cells through which said series current flows from the integration of the series current and for calculating the state of charge of each of the cells of the disconnected module from the open circuit voltage thereof. - switching means capable of selectively disconnecting one of the modules, the other modules remaining connected in series; and - a calculation means configured for calculating the state of charge of the cells through which said series current flows from the integration of the series current and for calculating the state of charge of each of the cells of the disconnected module from the open circuit voltage thereof.
A method of manufacturing a semiconductor element, comprising: a laser irradiation step of focusing a pulsed laser beam inside of a sapphire substrate (10, 20, 30, 40, 50) constituting a wafer (1, 2, 3), characterised in that the pulsed laser beam has a pulse width of 300 to 50000 fs, an amount of energy of 0.8 to 5 μJ per pulse and a frequency of 50 to 200 kHz, wherein a distance between the focal position of the pulsed laser beam and the surface of the sapphire substrate (10, 20, 30, 40, 50) is at least 5 μm or half a working spot diameter of the pulsed laser beam, and no more than 25 μm, thereby forming a plurality of isolated processed portions (12, 32) along an intended dividing line inside of the sapphire substrate (10, 20, 30, 40, 50), and creating a fissure (13, 33) that runs from the processed portions at least to the surface of the sapphire substrate (10, 20, 30, 40, 50) and links adjacent processed portions; wherein the distance between the processed portions is set to be at least the working spot diameter on a plane parallel to the substrate main face (10a, 10b, 30a, 30b), and a wafer division step of dividing the wafer along the intended dividing line. a laser irradiation step of focusing a pulsed laser beam inside of a sapphire substrate (10, 20, 30, 40, 50) constituting a wafer (1, 2, 3), characterised in that the pulsed laser beam has a pulse width of 300 to 50000 fs, an amount of energy of 0.8 to 5 μJ per pulse and a frequency of 50 to 200 kHz, wherein a distance between the focal position of the pulsed laser beam and the surface of the sapphire substrate (10, 20, 30, 40, 50) is at least 5 μm or half a working spot diameter of the pulsed laser beam, and no more than 25 μm, thereby forming a plurality of isolated processed portions (12, 32) along an intended dividing line inside of the sapphire substrate (10, 20, 30, 40, 50), and creating a fissure (13, 33) that runs from the processed portions at least to the surface of the sapphire substrate (10, 20, 30, 40, 50) and links adjacent processed portions; wherein the distance between the processed portions is set to be at least the working spot diameter on a plane parallel to the substrate main face (10a, 10b, 30a, 30b), and a wafer division step of dividing the wafer along the intended dividing line.
Electrical connection device for connecting at least one electric cable, comprising a base and at least one connection terminal mounted in the base, the connection terminal comprising a conductive part, a body and at least one spring adapted to maintain at least one electric cable in contact with the conductive part, characterised in that the body of the terminal is divided into two half-cases (16a, 16b) which are fitted together, and in that the base defines a housing which receives the body of each terminal, the conductive part being fixed in the housing, and the conductive part comprises an attachment member which holds the body in its housing of the base by resilient cooperation with a portion of the body.
A child seat that is mounted on a seat of an automobile by routing a seat belt of the automobile in a seat belt routing region, characterized in that the child seat comprises a lighting device that illuminates at least part of the seat belt routing region, a child seat body that has a seat portion and a backrest portion, and a base that supports the child seat body, wherein the lighting device is disposed so as to illuminate at least a rear side of the backrest portion.
A screw compressor comprising: a casing having a cylinder; a cylindrical-shaped screw rotor to be fitted to the cylinder; and a gate rotor to be engaged with the screw rotor, wherein the casing has a seal surface (17,18,19) opposed to one surface of the gate rotor, the seal surface (17,18,19) extending in a direction parallel to an axis of the screw rotor and having a width measured in a direction orthogonal to the axis of the screw rotor, wherein with regard to the width of the seal surface (17,18,19) of the casing, a width (Wd) on a gas-outlet side of the screw rotor is larger than a width (Ws) on a gas-inlet side of the screw rotor and characterized in that the seal surface (17,18,19) has a first edge on a screw rotor side and a second edge opposed to the first edge, the first edge is formed so as to be parallel to an axis of the screw rotor, the second edge has a first portion and a second portion in this order from gas inlet side toward outlet side of the screw rotor, and the first portion is formed so as to be farther from the first edge on its outlet side, while the second portion is formed so as to be parallel to the first edge. a casing having a cylinder; a cylindrical-shaped screw rotor to be fitted to the cylinder; and a gate rotor to be engaged with the screw rotor, wherein the casing has a seal surface (17,18,19) opposed to one surface of the gate rotor, the seal surface (17,18,19) extending in a direction parallel to an axis of the screw rotor and having a width measured in a direction orthogonal to the axis of the screw rotor, wherein with regard to the width of the seal surface (17,18,19) of the casing, a width (Wd) on a gas-outlet side of the screw rotor is larger than a width (Ws) on a gas-inlet side of the screw rotor and characterized in that the seal surface (17,18,19) has a first edge on a screw rotor side and a second edge opposed to the first edge, the first edge is formed so as to be parallel to an axis of the screw rotor, the second edge has a first portion and a second portion in this order from gas inlet side toward outlet side of the screw rotor, and the first portion is formed so as to be farther from the first edge on its outlet side, while the second portion is formed so as to be parallel to the first edge.
A compound for use in treating a patient suffering from a disease or a condition associated with GSNOR activity, the compound having a structure: or a pharmaceutically acceptable salt or ester thereof, wherein said disease or condition associated GSNOR activity is selected from the group consisting of: systemic hypertension, pulmonary artery hypertension, coronary atherosclerosis, systemic atherosclerosis, coronary artery re-stenosis, cardiac failure, congestive heart failure, cardiogenic shock, cardiomyopathy, septic shock, toxic shock syndrome, cerebrovascular accidents (CVAs), embolic disease, asthma, exercise-induced asthma, bronchiectasis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, lung disease due to cystic fibrosis, impotence, abnormalities of ejaculation, cystic fibrosis, sickle cell anemia, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, systemic inflammatory response syndrome, rheumatoid arthritis, Sjogren's syndrome, ulcerative colitis, Crohn's disease, glomerulonephritis, psoriasis, cutaneous lupus erythematosus, systemic lupus erythematosus, systemic sclerosis, dermatitis, hematologic tumors and solid tumors.
A method of ex vivo editing of a target genomic DNA in a mammalian stem cell, the method comprising: a) generating a modified mammalian stem cell that overexpresses the anti-apoptotic apoptosis regulator Bcl-2; and b) contacting the modified mammalian stem cell with a genome editing composition comprising a genome editing endonuclease, or a nucleic acid encoding the genome editing endonuclease, wherein the genome editing endonuclease cleaves within a desired target sequence of the genomic DNA of the cell, wherein the genome-editing endonuclease enters the modified stem cell and edits the target genomic DNA; wherein the mammalian cell is: a pluripotent stem cell or an adult stem cell; and/or a hematopoietic stem cell, a neural stem cell, a mesenchymal stem cell, or an induced pluripotent stem cell. a) generating a modified mammalian stem cell that overexpresses the anti-apoptotic apoptosis regulator Bcl-2; and b) contacting the modified mammalian stem cell with a genome editing composition comprising a genome editing endonuclease, or a nucleic acid encoding the genome editing endonuclease, wherein the genome editing endonuclease cleaves within a desired target sequence of the genomic DNA of the cell, wherein the genome-editing endonuclease enters the modified stem cell and edits the target genomic DNA; a pluripotent stem cell or an adult stem cell; and/or a hematopoietic stem cell, a neural stem cell, a mesenchymal stem cell, or an induced pluripotent stem cell.