A system for removing obstructive material from a body lumen, comprising: an outer tubular member comprising a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends; an obstruction device deployable from the tubular member to a location beyond obstructive material intended to be removed, the obstruction device comprising an expandable member on a distal end thereof; and a macerator device comprising an expandable cage carried on a distal end of a shaft and a constraint tube for maintaining the cage in a collapsed configuration to allow the macerator device to be introduced into the body lumen through the tubular member lumen, the cage being deployable from a distal end of the constraint tube and expandable to an expanded configuration within a body lumen, the cage comprising an open end communicating with an interior of the cage in the expanded configuration for capturing obstructive material within the interior of the cage; wherein the cage is retractable into the constraint tube after being expanded within a body lumen such that a closed end of the cage slidably engages the distal end of the constraint tube and the cage is compressed back towards the collapsed configuration; the system characterized in that: the cage comprises a tubular structure including a wall extending between the open end and the closed end of the cage, the wall comprising a plurality of apertures defined a desired pore size such that, when the cage slidably engages the distal end of the constraint tube as the cage is retracted into the constraint tube, obstructive material captured by the cage that extends through the apertures is separated from the cage by the distal end of the constraint tube; and the system further comprises: a source of vacuum coupled to the lumen of the tubular member for aspirating obstructive material separated from the cage into the lumen of the tubular member. an outer tubular member comprising a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends; an obstruction device deployable from the tubular member to a location beyond obstructive material intended to be removed, the obstruction device comprising an expandable member on a distal end thereof; and a macerator device comprising an expandable cage carried on a distal end of a shaft and a constraint tube for maintaining the cage in a collapsed configuration to allow the macerator device to be introduced into the body lumen through the tubular member lumen, the cage being deployable from a distal end of the constraint tube and expandable to an expanded configuration within a body lumen, the cage comprising an open end communicating with an interior of the cage in the expanded configuration for capturing obstructive material within the interior of the cage; the cage comprises a tubular structure including a wall extending between the open end and the closed end of the cage, the wall comprising a plurality of apertures defined a desired pore size such that, when the cage slidably engages the distal end of the constraint tube as the cage is retracted into the constraint tube, obstructive material captured by the cage that extends through the apertures is separated from the cage by the distal end of the constraint tube; and the system further comprises: a source of vacuum coupled to the lumen of the tubular member for aspirating obstructive material separated from the cage into the lumen of the tubular member. a source of vacuum coupled to the lumen of the tubular member for aspirating obstructive material separated from the cage into the lumen of the tubular member.