An imaging system for acquiring image data of a subject, comprising: a gantry having a fixed gantry portion and a moveable gantry portion, wherein the moveable gantry portion is configured to move relative to the fixed gantry portion to allow access to an imaging region defined by the gantry, wherein the gantry in a closed configuration is configured to surround at least a portion of the imaging region; a source assembly configured to move within the gantry; a plurality of source portions positioned within the source assembly, wherein each source portion is configured to selectively emit x-rays; a detector configured to move within the gantry, wherein the detector is configured to detect the emitted x-rays, wherein the detector includes an upper detecting surface which is planar, and wherein a normal line extends from a center of the upper detecting surface; and a controller configured to execute instructions to acquire image of the subject in the imaging region with at least one source portion of the plurality of source portions; wherein a first sub-plurality of source portions of the plurality of source portions are configured to acquire a first image data; wherein a second sub-plurality of source portions of the plurality of source portions are configured to acquire a second image data; wherein the source assembly including the plurality of source portions is positioned non-parallel with a plane of the gantry and are positioned anti-symmetrical relative to the detector; wherein the anti-symmetrical source assembly is positioned such that a first number of the plurality of source portions are positioned on a first side of the normal line and a second number of the plurality of source portions are positioned on a second side of the normal line such that the second number is greater than the first number. a gantry having a fixed gantry portion and a moveable gantry portion, wherein the moveable gantry portion is configured to move relative to the fixed gantry portion to allow access to an imaging region defined by the gantry, wherein the gantry in a closed configuration is configured to surround at least a portion of the imaging region; a source assembly configured to move within the gantry; a plurality of source portions positioned within the source assembly, wherein each source portion is configured to selectively emit x-rays; a detector configured to move within the gantry, wherein the detector is configured to detect the emitted x-rays, wherein the detector includes an upper detecting surface which is planar, and wherein a normal line extends from a center of the upper detecting surface; and wherein the detector is configured to detect the emitted x-rays, wherein the detector includes an upper detecting surface which is planar, and wherein a normal line extends from a center of the upper detecting surface; and a controller configured to execute instructions to acquire image of the subject in the imaging region with at least one source portion of the plurality of source portions; wherein a first sub-plurality of source portions of the plurality of source portions are configured to acquire a first image data; wherein a second sub-plurality of source portions of the plurality of source portions are configured to acquire a second image data; wherein the source assembly including the plurality of source portions is positioned non-parallel with a plane of the gantry and are positioned anti-symmetrical relative to the detector; wherein the anti-symmetrical source assembly is positioned such that a first number of the plurality of source portions are positioned on a first side of the normal line and a second number of the plurality of source portions are positioned on a second side of the normal line such that the second number is greater than the first number.