A compound represented by the following structural Formula: wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl; w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different; z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different; j and m are independently of each other 0, 1, 2, 3 or 4; when j is not 0, A 2 is selected from -NH-, -S-, -O-, ethenyl or a bond; when j is 0, A 2 is a bond or ethenyl; when m is not 0, A 1 is selected from -NH-, -S-, -O-, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl; n is 0, 1, 2, 3 or 4; R 1 is selected from hydrogen, OH, NH 2, C 1 -C 4 alkyl, halo, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl; R 2 is selected from hydrogen, OH, NH 2, C 1 -C 4 alkyl or halo; s is 1 or 2, and when s is 2, R 2 is the same or different; R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl; Ring B is cycloalkyl, heteroaryl, heterocyclic or aryl; R 3 is selected from hydrogen, OH, NH 2, nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(=O)O-, C 1 -C 7 alkyl-C(=O)-, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, -NHSO 2, -SO 2 NH, C 1 -C 7 alkyl-NHSO 2 -, C 1 -C 7 alkyl-SO 2 NH-, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7)alkylamino; t is 1, 2, 3 or 4; L 1 is (CH 2) r, cyclopropyl, or ethenyl, wherein r is 0, 1 or 2; Ring A is a 5 to 6 membered heteroaryl or aryl; Xis OH, SH or NH 2; p is 1, 2, 3 or 4; R 5 is selected from hydrogen, OH, NH 2, nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(=O)O-, C 1 -C 7 alkyl-C(=O)-, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, -NHSO 2, -SO 2 NH, C 1 -C 7 alkyl-NHSO 2 -, C 1 -C 7 alkyl-SO 2 NH-, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7)alkylamino or L 2 -R 16, wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, -O-, -S-, -N-, -C(=O)NH-, -NHC(=O)-, -NHC(=O)NH-, -SO 2 NH-, -NHO 2 -, -SO 2 -, -C(=O)- or -C(=O)O-; or a stereoisomer or pharmaceutically acceptable salt thereof. wherein Y 1 and Y 2 are, independently of each other, hydrogen, a substituted or unsubstituted C 3 -C 8 cycloalkyl, substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 1 -C 10 alkenyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl; w is 1 or 2, wherein when w is 2, the two Y 1 are the same or different; z is 1 or 2, wherein when z is 2, the two Y 2 are the same or different; j and m are independently of each other 0, 1, 2, 3 or 4; when j is not 0, A 2 is selected from -NH-, -S-, -O-, ethenyl or a bond; when j is 0, A 2 is a bond or ethenyl; when m is not 0, A 1 is selected from -NH-, -S-, -O-, ethenyl or a bond; when m is 0, A 1 is a bond or ethenyl; n is 0, 1, 2, 3 or 4; R 1 is selected from hydrogen, OH, NH 2, C 1 -C 4 alkyl, halo, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic or substituted or unsubstituted aryl; R 2 is selected from hydrogen, OH, NH 2, C 1 -C 4 alkyl or halo; s is 1 or 2, and when s is 2, R 2 is the same or different; R 9 and R 14 are independently of each other selected from hydrogen or C 1 -C 4 alkyl; Ring B is cycloalkyl, heteroaryl, heterocyclic or aryl; R 3 is selected from hydrogen, OH, NH 2, nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(=O)O-, C 1 -C 7 alkyl-C(=O)-, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, -NHSO 2, -SO 2 NH, C 1 -C 7 alkyl-NHSO 2 -, C 1 -C 7 alkyl-SO 2 NH-, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7)alkylamino; t is 1, 2, 3 or 4; L 1 is (CH 2) r, cyclopropyl, or ethenyl, wherein r is 0, 1 or 2; Ring A is a 5 to 6 membered heteroaryl or aryl; Xis OH, SH or NH 2; p is 1, 2, 3 or 4; R 5 is selected from hydrogen, OH, NH 2, nitro, CN, amide, carboxyl, C 1 -C 7 alkoxy, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 haloalkyloxy, C 1 -C 7 hydroxyalkyl, C 1 -C 7 alkenyl, C 1 -C 7 alkyl-C(=O)O-, C 1 -C 7 alkyl-C(=O)-, C 1 -C 7 alkynyl, halo group, amide, hydroxyalkoxy, -NHSO 2, -SO 2 NH, C 1 -C 7 alkyl-NHSO 2 -, C 1 -C 7 alkyl-SO 2 NH-, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylamino or di(C 1 -C 7)alkylamino or L 2 -R 16, wherein R 16 is substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, substituted or unsubstituted C 3 -C 8 cycloalkyl, L 2 is selected from a bond, C 1 -C 4 alkylene, C 1 -C 4 alkynyl, C 1 -C 4 alkenyl, -O-, -S-, -N-, -C(=O)NH-, -NHC(=O)-, -NHC(=O)NH-, -SO 2 NH-, -NHO 2 -, -SO 2 -, -C(=O)- or -C(=O)O-;