An electromagnetic navigation system for guiding and tracking an interventional tool within an anatomical region, the electromagnetic navigation system comprising: a guidewire operable to be inserted into the anatomical region, wherein the guidewire includes a plurality of guidance electromagnetic sensors operable to generate guidance data informative of an electromagnetic sensing of at least a position and an orientation of the guidewire relative to the anatomical region; a hub operable, in conjunction with the interventional tool, to be at least one of translated and rotated relative to the guidewire, wherein the hub includes a tracking electromagnetic sensor operable to generate tracking data informative of an electromagnetic sensing at least one of a position and an orientation of the hub relative to the guidewire, and wherein the guidance data and the tracking data are collectively informative of at least one of a position and an orientation of the interventional tool relative to the guidewire; and a navigation controller operable, in response to a generation of the guidance data by the plurality of guidance electromagnetic sensors and a generation of the tracking data by the tracking electromagnetic sensor, to control a determination of the at least one of the position and the orientation of the interventional tool relative to the guidewire; and wherein the determination by the navigation controller of the at least one of the position and the orientation of the interventional tool relative to the guidewire includes: i): the navigation controller further operable to control an interpolation of a spatial distance between an electromagnetic sensed position of the plurality of guidance electromagnetic sensors and an electromagnetic sensed position of the tracking electromagnetic sensor; or ii) the navigation controller further operable to control a projection of a position of the tracking electromagnetic sensor onto the guidewire derived from an interpolation of the spatial distance between the electromagnetic sensed position of the plurality of guidance electromagnetic sensors and the electromagnetic sensed position of the tracking electromagnetic sensor. a guidewire operable to be inserted into the anatomical region, wherein the guidewire includes a plurality of guidance electromagnetic sensors operable to generate guidance data informative of an electromagnetic sensing of at least a position and an orientation of the guidewire relative to the anatomical region; a hub operable, in conjunction with the interventional tool, to be at least one of translated and rotated relative to the guidewire, wherein the hub includes a tracking electromagnetic sensor operable to generate tracking data informative of an electromagnetic sensing at least one of a position and an orientation of the hub relative to the guidewire, and wherein the guidance data and the tracking data are collectively informative of at least one of a position and an orientation of the interventional tool relative to the guidewire; and wherein the hub includes a tracking electromagnetic sensor operable to generate tracking data informative of an electromagnetic sensing at least one of a position and an orientation of the hub relative to the guidewire, and wherein the guidance data and the tracking data are collectively informative of at least one of a position and an orientation of the interventional tool relative to the guidewire; and a navigation controller operable, in response to a generation of the guidance data by the plurality of guidance electromagnetic sensors and a generation of the tracking data by the tracking electromagnetic sensor, to control a determination of the at least one of the position and the orientation of the interventional tool relative to the guidewire; and wherein the determination by the navigation controller of the at least one of the position and the orientation of the interventional tool relative to the guidewire includes: i): the navigation controller further operable to control an interpolation of a spatial distance between an electromagnetic sensed position of the plurality of guidance electromagnetic sensors and an electromagnetic sensed position of the tracking electromagnetic sensor; or ii) the navigation controller further operable to control a projection of a position of the tracking electromagnetic sensor onto the guidewire derived from an interpolation of the spatial distance between the electromagnetic sensed position of the plurality of guidance electromagnetic sensors and the electromagnetic sensed position of the tracking electromagnetic sensor. i): the navigation controller further operable to control an interpolation of a spatial distance between an electromagnetic sensed position of the plurality of guidance electromagnetic sensors and an electromagnetic sensed position of the tracking electromagnetic sensor; or ii) the navigation controller further operable to control a projection of a position of the tracking electromagnetic sensor onto the guidewire derived from an interpolation of the spatial distance between the electromagnetic sensed position of the plurality of guidance electromagnetic sensors and the electromagnetic sensed position of the tracking electromagnetic sensor.