A system for generating a finite element model of an anatomical structure based on a fitted model of the anatomical structure and association data, the system comprising: - an input interface configured for receiving: i) model data defining a segmentation model for segmenting the anatomical structure, the segmentation model representing a reference shape of the anatomical structure, and ii) association data associating a segmentation model part of the segmentation model with a mesh property, the segmentation model part representing a pre-determined anatomical region of interest, wherein the mesh property is one out of: (i) a mesh resolution; (ii) a finite element type; - a segmentation subsystem configured for applying the segmentation model to a medical image of a subject, so as to fit the segmentation model to the anatomical structure in the medical image, thereby obtaining a fitted model providing a segmentation of the anatomical structure, the fitted model comprising a fitted model part providing a segmentation of the pre-determined anatomical region of interest; - a finite element model generating subsystem configured for generating the finite element model based on the fitted model and the association data, said generating comprising meshing a finite element model part of the finite element model in accordance with the mesh property, the finite element model part corresponding with the pre-determined anatomical region of interest, characterized in that, the mesh property is selected based on at least one out of: (i) a material type of the pre-determined anatomical region of interest; (ii) a mechanical boundary condition at the pre-determined anatomical region of interest. - an input interface configured for receiving: i) model data defining a segmentation model for segmenting the anatomical structure, the segmentation model representing a reference shape of the anatomical structure, and ii) association data associating a segmentation model part of the segmentation model with a mesh property, the segmentation model part representing a pre-determined anatomical region of interest, wherein the mesh property is one out of: (i) a mesh resolution; (ii) a finite element type; i) model data defining a segmentation model for segmenting the anatomical structure, the segmentation model representing a reference shape of the anatomical structure, and ii) association data associating a segmentation model part of the segmentation model with a mesh property, the segmentation model part representing a pre-determined anatomical region of interest, wherein the mesh property is one out of: (i) a mesh resolution; (ii) a finite element type; (i) a mesh resolution; (ii) a finite element type; - a segmentation subsystem configured for applying the segmentation model to a medical image of a subject, so as to fit the segmentation model to the anatomical structure in the medical image, thereby obtaining a fitted model providing a segmentation of the anatomical structure, the fitted model comprising a fitted model part providing a segmentation of the pre-determined anatomical region of interest; - a finite element model generating subsystem configured for generating the finite element model based on the fitted model and the association data, said generating comprising meshing a finite element model part of the finite element model in accordance with the mesh property, the finite element model part corresponding with the pre-determined anatomical region of interest, characterized in that, the mesh property is selected based on at least one out of: (i) a material type of the pre-determined anatomical region of interest; (ii) a mechanical boundary condition at the pre-determined anatomical region of interest. (i) a material type of the pre-determined anatomical region of interest; (ii) a mechanical boundary condition at the pre-determined anatomical region of interest.