mhurhangee/ep-ind-claims huggingface dataset:
An antibody which specifically binds to Siglec-15 or an antigen binding fragment of the antibody, characterized by comprising (i) a heavy chain variable region sequence comprising amino acid residues 20 to 140 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain variable region sequence comprising amino acid residues 21 to 133 of an amino acid sequence represented by SEQ ID NO: 4, (ii) a heavy chain sequence comprising amino acid residues 20 to 466 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain sequence comprising amino acid residues 21 to 238 of an amino acid sequence represented by SEQ ID NO: 4, or (iii) a heavy chain sequence comprising amino acid residues 20 to 465 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain sequence comprising amino acid residues 21 to 238 of an amino acid sequence represented by SEQ ID NO: 4. (i) a heavy chain variable region sequence comprising amino acid residues 20 to 140 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain variable region sequence comprising amino acid residues 21 to 133 of an amino acid sequence represented by SEQ ID NO: 4, (ii) a heavy chain sequence comprising amino acid residues 20 to 466 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain sequence comprising amino acid residues 21 to 238 of an amino acid sequence represented by SEQ ID NO: 4, or (iii) a heavy chain sequence comprising amino acid residues 20 to 465 of an amino acid sequence represented by SEQ ID NO: 6 and a light chain sequence comprising amino acid residues 21 to 238 of an amino acid sequence represented by SEQ ID NO: 4.
A computer implemented method for application launching and/or switching in a computing device, the method comprising: receiving an interactive gesture at the computing device; when the interactive gesture matches a predefined gesture, determining a current context of the computing device based at least on one or more tasks, the tasks including previously performed tasks at the computing device and predicted future tasks to be performed at the computing device, the current context being associated with a time at which the interactive gesture is received and indicating with respect to said time what tasks have previously been performed and what future tasks are predicted to be performed after said time; based on the determined context, identifying one or more software applications, the software applications including executing applications, terminated applications or uninstalled applications, to perform one or more of the predicted future tasks; and displaying one or more user interface elements representing the one or more identified software applications, wherein the user interface elements are selectable to instantiate the identified software applications. receiving an interactive gesture at the computing device; when the interactive gesture matches a predefined gesture, determining a current context of the computing device based at least on one or more tasks, the tasks including previously performed tasks at the computing device and predicted future tasks to be performed at the computing device, the current context being associated with a time at which the interactive gesture is received and indicating with respect to said time what tasks have previously been performed and what future tasks are predicted to be performed after said time; based on the determined context, identifying one or more software applications, the software applications including executing applications, terminated applications or uninstalled applications, to perform one or more of the predicted future tasks; and displaying one or more user interface elements representing the one or more identified software applications, wherein the user interface elements are selectable to instantiate the identified software applications.
An isolated antibody that binds to Ly6E, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:32, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:33; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:34, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:29; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:30; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:31.
An apparatus for transmitting a synchronization signal, comprising: a radio resource configuring unit adapted to configure a plurality of radio resource blocks, each of the plurality of radio resource blocks including two or more neighboring radio resource elements of radio resource elements included in a radio resource for synchronization, wherein the radio resource for synchronization is a symbol among a plurality of symbols included in a downlink synchronization channel subframe periodically allocated; wherein the radio resource for synchronization includes a first synchronization signal, a second synchronization signal and a third synchronization signal; a timing synchronization performing unit configured to transmit, to a terminal, the first synchronization signal for frequency synchronization and the second synchronization signal for frame synchronization in order to perform timing synchronization; and a beamforming synchronization performing unit configured to transmit a beam synchronization signal as the third synchronization signal in different directions through a plurality of antennas, through antenna beams formed for each of the plurality of radio resource blocks, to the terminal in order to perform beamforming synchronization based on the beam synchronization signal; wherein each of the two or more neighboring radio resource elements occupies a minimum frequency element required for generating one antenna beam by the receiving device, and wherein the two or more neighboring radio resource elements are neighboring in frequency direction. a radio resource configuring unit adapted to configure a plurality of radio resource blocks, each of the plurality of radio resource blocks including two or more neighboring radio resource elements of radio resource elements included in a radio resource for synchronization, wherein the radio resource for synchronization is a symbol among a plurality of symbols included in a downlink synchronization channel subframe periodically allocated; wherein the radio resource for synchronization includes a first synchronization signal, a second synchronization signal and a third synchronization signal; a timing synchronization performing unit configured to transmit, to a terminal, the first synchronization signal for frequency synchronization and the second synchronization signal for frame synchronization in order to perform timing synchronization; and a beamforming synchronization performing unit configured to transmit a beam synchronization signal as the third synchronization signal in different directions through a plurality of antennas, through antenna beams formed for each of the plurality of radio resource blocks, to the terminal in order to perform beamforming synchronization based on the beam synchronization signal; wherein each of the two or more neighboring radio resource elements occupies a minimum frequency element required for generating one antenna beam by the receiving device, and wherein the two or more neighboring radio resource elements are neighboring in frequency direction.
A process for the conversion of a paraffinic feedstock constituted by hydrocarbons containing in the range 9 to 25 carbon atoms, wherein said paraffinic feed is produced from renewable resources, to the exclusion of paraffinic feedstocks obtained by a process comprising a upgrading step by a Fischer-Tropsch method, wherein said process employs a catalyst comprising at least one hydro-dehydrogenating metal selected from the group formed by metals from group VIB and from group VIII of the periodic classification of the elements, used alone or as a mixture, and a support comprising at least one Nu-10 zeolite and at least one ZSM-48 zeolite, wherein said process operates at a temperature ranging from 150°C to 500°C, at a pressure ranging from 0.1 MPa to 15 MPa, at an hourly space velocity ranging from 0.1 to 10 h -1 and in the presence of a total amount of hydrogen mixed with the feedstock such that the hydrogen/feedstock ratio is in the range 70 to 2000 Nm 3 /m 3 of feedstock.
A method of operating a compression ignition engine on a fuel consisting of methanol, dimethyl ether and water, wherein the fuel has been prepared by catalytic dehydration of methanol and contains dimethyl ether as the main component, said method comprising the steps of injecting the fuel into the combustion chamber of the engine and combusting the fuel with air, wherein the air for combustion is preheated to a temperature of at least 60°C.
An unshaped product intended for the manufacture of a sintered refractory product, said unshaped product comprising a particulate mixture consisting of: - a coarse fraction, representing more than 50% and less than 91% of the particulate mixture, as weight percentage, and consisting of the particles having a size greater than or equal to 50 μm, referred to as "coarse particles", and - a matrix fraction, forming the remainder up to 100% of the particulate mixture, and consisting of the particles having a size less than 50 μm, referred to as "matrix particles", the product having a chemical analysis, as weight percentage on the basis of the oxides of the product, such that: - 45% < Al 2 O 3, - 7.5% < SiO 2 < 35% and 0% ≤ ZrO 2 < 33%, provided that 10% < SiO 2 + ZrO 2 < 54%, - 0.15% < B 2 O 3 < 8%, - other oxides: < 6%, Al 2 O 3 constituting the remainder up to 100%, said coarse fraction comprising more than 15% of coarse particles having a size greater than 1 mm, as weight percentage on the basis of the particulate mixture, said matrix fraction having a chemical analysis, as weight percentage on the basis of the oxides of the matrix fraction, such that: - Al 2 O 3 + SiO 2 + ZrO 2 > 86%, provided that 35% < Al 2 O 3. - a coarse fraction, representing more than 50% and less than 91% of the particulate mixture, as weight percentage, and consisting of the particles having a size greater than or equal to 50 μm, referred to as "coarse particles", and - a matrix fraction, forming the remainder up to 100% of the particulate mixture, and consisting of the particles having a size less than 50 μm, referred to as "matrix particles", - 45% < Al 2 O 3, - 7.5% < SiO 2 < 35% and 0% ≤ ZrO 2 < 33%, provided that 10% < SiO 2 + ZrO 2 < 54%, - 0.15% < B 2 O 3 < 8%, - other oxides: < 6%, - Al 2 O 3 + SiO 2 + ZrO 2 > 86%, provided that 35% < Al 2 O 3.
Casting mould for casting complex-shaped, large-volume castings from a molten metal, wherein the casting mould has a mould cavity forming the casting and a delivery system for delivery of the molten metal, which is to be cast into the casting, into the mould cavity, wherein the delivery system comprises a sprue, a runner connected to the sprue and a feeder system connected to the runner, and wherein the mould cavity is connected to the feeder system or the runner via connections (9a, 9b), characterised in that when seen in the flow direction of the molten metal flowing from the sprue into the runner during the casting operation, the runner, having a branch (18, 19) directed away from the sprue along the feeder system and having a directed-back branch adjoining the directed-away branch (18, 19), is guided along the feeder system in the opposite direction to the directed-away branch (18, 19), and in that the feeder system is connected to both the directed-away branch (18, 19) and the directed-back branch via two or more gates (21, 24) distributed along the respective branch (18, 19, 20).
A device for fluorescence-based imaging and monitoring of a target comprising: a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce; an optical filter holder configured to accommodate one or more optical filters; a power supply; a digital image acquisition device having a lens and configured to acquire a fluorescence based image of the target secured within the housing, wherein the digital image acquisition device is a digital camera, video recorder, camcorder, cellular telephone with a built-in digital camera, smart phone with a digital camera, a personal digital assistant, or a webcam; and a housing that houses the all the components of the device in one entity and comprises means of securing the digital image acquisition device within the housing, wherein the housing is configured to be hand-held, compact and portable. a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce; an optical filter holder configured to accommodate one or more optical filters; a power supply; a digital image acquisition device having a lens and configured to acquire a fluorescence based image of the target secured within the housing, wherein the digital image acquisition device is a digital camera, video recorder, camcorder, cellular telephone with a built-in digital camera, smart phone with a digital camera, a personal digital assistant, or a webcam; and a housing that houses the all the components of the device in one entity and comprises means of securing the digital image acquisition device within the housing, wherein the housing is configured to be hand-held, compact and portable.
Operating element for operating a clamping spring of a connection terminal, comprising • an operating finger which has an operating face by means of which the operating finger pushes on a clamping limb of the clamping spring during operation of the clamping spring, characterized in that the operating element comprises a covering element which forms an extension of the operating finger in the longitudinal extent of the operating finger, • wherein the covering element is integrally formed on the side of the operating finger. • an operating finger which has an operating face by means of which the operating finger pushes on a clamping limb of the clamping spring during operation of the clamping spring, characterized in that the operating element comprises a covering element which forms an extension of the operating finger in the longitudinal extent of the operating finger, • wherein the covering element is integrally formed on the side of the operating finger.
A circulating fluidized bed boiler comprising: a circulating fluidized bed reaction chamber having side walls (2a-2d) and a grid defining a floor at a lower end of the circulating fluidized bed reaction chamber for providing fluidizing gas (8, 45, 46) into the circulating fluidized bed reaction chamber; a bubbling fluidized bed located within a lower portion of the circulating fluidized bed reaction chamber and being bound by one or more of the side walls of the circulating fluidized bed reaction chamber, the floor of the circulating fluidized bed reaction chamber, and an enclosure wall formed by cooled tubes that extend upward from the floor of the circulating fluidized bed to a height of the bubbling fluidized bed; at least one controllable in-bed heat exchanger immersed in the bubbling fluidized bed, the in-bed heat exchanger comprising a heating surface and occupying part of the circulating fluidized bed reaction chamber floor and being surrounded by the enclosure wall and one or more of the side walls; and characterized in that it further comprises at least one in-furnace secondary air nozzle formed by the cooled tubes of the bubbling fluidized bed enclosure wall that are formed into at least one group that extends from a top of the bubbling fluidized bed enclosure wall across the width of the bubbling fluidized bed until reaching one of the side walls of the circulating fluidized bed, the secondary air nozzles thereby providing that air introduced via the secondary air nozzles does not deflect solids (18, 19) from falling onto the bubbling fluidized bed. a circulating fluidized bed reaction chamber having side walls (2a-2d) and a grid defining a floor at a lower end of the circulating fluidized bed reaction chamber for providing fluidizing gas (8, 45, 46) into the circulating fluidized bed reaction chamber; a bubbling fluidized bed located within a lower portion of the circulating fluidized bed reaction chamber and being bound by one or more of the side walls of the circulating fluidized bed reaction chamber, the floor of the circulating fluidized bed reaction chamber, and an enclosure wall formed by cooled tubes that extend upward from the floor of the circulating fluidized bed to a height of the bubbling fluidized bed; at least one controllable in-bed heat exchanger immersed in the bubbling fluidized bed, the in-bed heat exchanger comprising a heating surface and occupying part of the circulating fluidized bed reaction chamber floor and being surrounded by the enclosure wall and one or more of the side walls; and characterized in that it further comprises at least one in-furnace secondary air nozzle formed by the cooled tubes of the bubbling fluidized bed enclosure wall that are formed into at least one group that extends from a top of the bubbling fluidized bed enclosure wall across the width of the bubbling fluidized bed until reaching one of the side walls of the circulating fluidized bed, the secondary air nozzles thereby providing that air introduced via the secondary air nozzles does not deflect solids (18, 19) from falling onto the bubbling fluidized bed.
A tooling suitable for the curing of composite pieces, comprising a) a support structure made of a metallic material with high thermal diffusivity; characterized in that it further comprises: b) a base plate with an identical surface geometry as that of the piece to be cured, made of a binary Nickel-Iron alloy with a low coefficient of thermal expansion and with 36% of Nickel; c) an intermediate structure between the support structure and the base plate with a cell configuration, with the sides of each cell being sufficiently lightened so as to facilitate the flow of air under the base plate during the curing cycle, made of a binary Nickel-Iron alloy with a low coefficient of thermal expansion and with 36% of Nickel; and d) means of fixing the intermediate structure to the support structure allowing their free expansion. a) a support structure made of a metallic material with high thermal diffusivity; characterized in that it further comprises: b) a base plate with an identical surface geometry as that of the piece to be cured, made of a binary Nickel-Iron alloy with a low coefficient of thermal expansion and with 36% of Nickel; c) an intermediate structure between the support structure and the base plate with a cell configuration, with the sides of each cell being sufficiently lightened so as to facilitate the flow of air under the base plate during the curing cycle, made of a binary Nickel-Iron alloy with a low coefficient of thermal expansion and with 36% of Nickel; and d) means of fixing the intermediate structure to the support structure allowing their free expansion.
A compound of formula, an isomer or a pharmaceutically acceptable salt thereof, wherein, R 1 is selected from C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R a; R 2 is selected from Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R b; R 3, R 4, R 5, R 6 and R 7 are each independently selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R c; R 8, R 9, R 10 and R 11 are each independently selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R d; E 1 is -(CH 2) m-; E 2 is -(CH 2) n-; m is 0, 1 or 2; n is 0, 1 or 2; R a, R b, R c and R d are each independently selected from F, Cl, Br, I, OH and NH 2, wherein the term isomer refers to enantiomers, diastereomers and geometrical isomers. R 1 is selected from C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R a; R 2 is selected from Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R b; R 3, R 4, R 5, R 6 and R 7 are each independently selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R c; R 8, R 9, R 10 and R 11 are each independently selected from H, F, Cl, Br, I, OH, NH 2 and C 1-3 alkyl, wherein the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R d; E 1 is -(CH 2) m-; E 2 is -(CH 2) n-; m is 0, 1 or 2; n is 0, 1 or 2; R a, R b, R c and R d are each independently selected from F, Cl, Br, I, OH and NH 2, wherein the term isomer refers to enantiomers, diastereomers and geometrical isomers.
A product authentication method, comprising: (a) combining (i) a surface associated with a product with (ii) a solution comprising a first nucleic acid strand comprising a 5' domain, a 3' domain, and a 5' fluorescent molecule or a 5' quencher molecule, optionally wherein the surface is a surface of a package containing the product or an identification tag accompanying the product, or combining a sample of a product, optionally a liquid product, with a first nucleic acid strand comprising a 5' domain, a 3' domain, and a 5' fluorescent molecule or a 5' quencher molecule, wherein the surface or sample comprises a second nucleic acid strand comprising a 5'domain complementary to the 3'domain of the first strand, a 3' domain complementary to the 5' domain of the first strand, and a 3' quencher molecule or a 3' fluorescent molecule, wherein binding of the first strand to the second strand quenches fluorescent signal emitted by the 5' fluorescent molecule or the 3' fluorescent molecule, wherein the first nucleic acid strand and/or the second nucleic acid strand comprise(s) L-DNA and/or stopper molecules; and (b) assaying for fluorescence on the surface, in the solution, or in the sample. (a) combining (i) a surface associated with a product with (ii) a solution comprising a first nucleic acid strand comprising a 5' domain, a 3' domain, and a 5' fluorescent molecule or a 5' quencher molecule, optionally wherein the surface is a surface of a package containing the product or an identification tag accompanying the product, or combining a sample of a product, optionally a liquid product, with a first nucleic acid strand comprising a 5' domain, a 3' domain, and a 5' fluorescent molecule or a 5' quencher molecule, wherein the surface or sample comprises a second nucleic acid strand comprising a 5'domain complementary to the 3'domain of the first strand, a 3' domain complementary to the 5' domain of the first strand, and a 3' quencher molecule or a 3' fluorescent molecule, wherein binding of the first strand to the second strand quenches fluorescent signal emitted by the 5' fluorescent molecule or the 3' fluorescent molecule, wherein the first nucleic acid strand and/or the second nucleic acid strand comprise(s) L-DNA and/or stopper molecules; and wherein the surface or sample comprises a second nucleic acid strand comprising a 5'domain complementary to the 3'domain of the first strand, a 3' domain complementary to the 5' domain of the first strand, and a 3' quencher molecule or a 3' fluorescent molecule, wherein binding of the first strand to the second strand quenches fluorescent signal emitted by the 5' fluorescent molecule or the 3' fluorescent molecule, wherein the first nucleic acid strand and/or the second nucleic acid strand comprise(s) L-DNA and/or stopper molecules; and (b) assaying for fluorescence on the surface, in the solution, or in the sample.
A CD19xCD3 bispecific single chain antibody for use in a method for treating pediatric B-precursor ALL in a subject, wherein said subject is a subject having an amount of at least 20% blast cells per 200 counted bone marrow cells in a bone marrow sample from said subject.