mhurhangee/ep-ind-claims huggingface dataset:
A method for the chemo- and/or regioselective derivatization of a target compound comprising multiple chemically equivalent reactive groups, wherein at least one reactive group is to be derivatized and wherein at least one reactive group is not to be derivatized, the method comprising the steps of a. contacting the target compound with at least one non-covalent protective group under conditions allowing for the formation of a regioselective host-guest complex, wherein the target compound is an aminoglycoside antibiotic based on a neamine scaffold and wherein the protective group is a DNA or RNA aptamer or oligopeptide aptamer having a selective affinity for the at least one reactive group not to be modified, wherein the RNA or DNA aptamer consists of from 8 to 60 nucleotides and is obtained by a screening process comprises the steps of: constructing a random single-stranded DNA (ssDNA) library and preparing a primer; preparing the random single-stranded DNA (ssDNA) library by PCR amplification (for DNA SELEX) or an RNA library by transcription (for RNA SELEX); carrying out multiple rounds of SELEX screening; detecting the appetency; cloning and sequencing DNA, or wherein the oligopeptide aptamer is obtained by expressing a library of candidate oligopeptide aptamers in a recombinant host cell by infection with phages, selecting at least one host cell expressing an oligopeptide aptamer, and identifying the oligopeptide aptamer; followed and/or accompanied by b. chemical derivatization of the target compound. a. contacting the target compound with at least one non-covalent protective group under conditions allowing for the formation of a regioselective host-guest complex, wherein the target compound is an aminoglycoside antibiotic based on a neamine scaffold and wherein the protective group is a DNA or RNA aptamer or oligopeptide aptamer having a selective affinity for the at least one reactive group not to be modified, wherein the RNA or DNA aptamer consists of from 8 to 60 nucleotides and is obtained by a screening process comprises the steps of: constructing a random single-stranded DNA (ssDNA) library and preparing a primer; preparing the random single-stranded DNA (ssDNA) library by PCR amplification (for DNA SELEX) or an RNA library by transcription (for RNA SELEX); carrying out multiple rounds of SELEX screening; detecting the appetency; cloning and sequencing DNA, or wherein the oligopeptide aptamer is obtained by expressing a library of candidate oligopeptide aptamers in a recombinant host cell by infection with phages, selecting at least one host cell expressing an oligopeptide aptamer, and identifying the oligopeptide aptamer; followed and/or accompanied by b. chemical derivatization of the target compound.
A mount for attaching a display device to a surface, the mount comprising: a keyed insert comprising: a key base; and a keyed plate mounted to the key base and having one or more key features (56a-56c) extending from a periphery of the keyed plate; a key receiver that accepts the keyed insert, the key receiver comprising: a receiver base; a retaining ring connected to the receiver base; said mount being characterised in that the key receiver further comprises: a key set ring disposed between the retaining ring and the receiver base, the key set ring comprising: one or more receiving notches (62a-62c) configured to receive the one or more key features (56a-56c); and one or more locking notches (64a-64c) spaced away from the receiving notch (62a-62c) and configured to lockingly engage the one or more key features (56a-56c); a key entrance ring disposed between the retaining ring and the key set ring, the key entrance ring comprising one or more index notches (60a-60c) aligned with the one or more receiving notches (62a-62c); and a spring plate movable between the key set ring and the receiver base. a keyed insert comprising: a key base; and a keyed plate mounted to the key base and having one or more key features (56a-56c) extending from a periphery of the keyed plate; a key base; and a keyed plate mounted to the key base and having one or more key features (56a-56c) extending from a periphery of the keyed plate; a key receiver that accepts the keyed insert, the key receiver comprising: a receiver base; a retaining ring connected to the receiver base; a receiver base; a retaining ring connected to the receiver base; a key set ring disposed between the retaining ring and the receiver base, the key set ring comprising: one or more receiving notches (62a-62c) configured to receive the one or more key features (56a-56c); and one or more locking notches (64a-64c) spaced away from the receiving notch (62a-62c) and configured to lockingly engage the one or more key features (56a-56c); one or more receiving notches (62a-62c) configured to receive the one or more key features (56a-56c); and one or more locking notches (64a-64c) spaced away from the receiving notch (62a-62c) and configured to lockingly engage the one or more key features (56a-56c); a key entrance ring disposed between the retaining ring and the key set ring, the key entrance ring comprising one or more index notches (60a-60c) aligned with the one or more receiving notches (62a-62c); and a spring plate movable between the key set ring and the receiver base.
A method for operating in a terminal device for downlink flow control, the terminal device receiving duplicated packets from a first network node device and one or more secondary network node devices, the method comprising: measuring downlink transmission information for the first network node device and the one or more secondary network node devices, wherein the downlink transmission information comprises a downlink transmission status; deciding downlink flow control information based on the measured downlink transmission information, wherein deciding the downlink flow control information based on the measured downlink transmission information comprises: determining from which packet the first network node device and the one or more secondary network node devices subsequently deliver the duplicated packets to the terminal device, based on the downlink transmission status; and sending (S230, S431) the downlink flow control information to at least the first network node device. measuring downlink transmission information for the first network node device and the one or more secondary network node devices, wherein the downlink transmission information comprises a downlink transmission status; deciding downlink flow control information based on the measured downlink transmission information, wherein deciding the downlink flow control information based on the measured downlink transmission information comprises: determining from which packet the first network node device and the one or more secondary network node devices subsequently deliver the duplicated packets to the terminal device, based on the downlink transmission status; and sending (S230, S431) the downlink flow control information to at least the first network node device.
An energy network comprising: a plurality of variable power loads including at least one electrolyser, the plurality of variable power loads being connected to a plurality of electricity generating stations by a grid, wherein the electrolyser is located at a point on the grid adapted to relieve periods of excess supply over demand, or instability where a renewable energy source is connected; and a controller connected to receive requests from said grid and operable to control said at least one electrolyser in response to said requests to relieve periods of excess supply over demand or instability by absorbing power from said renewable energy source to generate hydrogen which is dumped to a natural gas pipeline. a plurality of variable power loads including at least one electrolyser, the plurality of variable power loads being connected to a plurality of electricity generating stations by a grid, wherein the electrolyser is located at a point on the grid adapted to relieve periods of excess supply over demand, or instability where a renewable energy source is connected; and a controller connected to receive requests from said grid and operable to control said at least one electrolyser in response to said requests to relieve periods of excess supply over demand or instability by absorbing power from said renewable energy source to generate hydrogen which is dumped to a natural gas pipeline.
A dispenser for ejecting a substance consisting of several components, comprising: at least two containers (6a, 6b) in an outer sleeve for receiving the components of the substance; a pump unit (2a, 2b) at each of the containers (6a, 6b); an adjusting device with which the quantity ratio of the components to each other can be adjusted; a movable actuation device for the pump units (2a, 2b) and/or containers (6a, 6b); and a dispenser element for the substance to be ejected by the dispenser; and a force transmission element which is movable relative to the outer sleeve and in an axial direction of the dispenser when the actuation device is impinged, characterized in that the actuation device is realized separately from the containers (6a, 6b) and that the force transmission element is arranged movably between the containers (6a, 6b) relative to them. at least two containers (6a, 6b) in an outer sleeve for receiving the components of the substance; a pump unit (2a, 2b) at each of the containers (6a, 6b); an adjusting device with which the quantity ratio of the components to each other can be adjusted; a movable actuation device for the pump units (2a, 2b) and/or containers (6a, 6b); and a dispenser element for the substance to be ejected by the dispenser; and a force transmission element which is movable relative to the outer sleeve and in an axial direction of the dispenser when the actuation device is impinged, characterized in that the actuation device is realized separately from the containers (6a, 6b) and that the force transmission element is arranged movably between the containers (6a, 6b) relative to them.
An apparatus (200, 300, 400, 500), comprising: an enclosure defining an enclosed cavity; a thermoelectric component arranged to receive thermal energy and to convert the thermal energy to electrical energy; one or more components coupled to the thermoelectric component and arranged to receive the electrical energy from the thermoelectric component; a phase change material disposed within the enclosed cavity, the phase change material operative to absorb thermal energy and change from an initial state of matter to a secondary state of matter in response to absorption of the thermal energy; the apparatus being characterized by one or more traces coupling the thermoelectric component with the one or more components, the one or more traces comprised of a thermal conductive material operative to thermally couple with the phase change material to transfer the absorbed thermal energy from the phase change material to the thermoelectric component and operative to convey the electrical energy from the thermoelectric component to the one or more components; and a printed circuit board, the one or more components disposed on the printed circuit board. an enclosure defining an enclosed cavity; a thermoelectric component arranged to receive thermal energy and to convert the thermal energy to electrical energy; one or more components coupled to the thermoelectric component and arranged to receive the electrical energy from the thermoelectric component; a phase change material disposed within the enclosed cavity, the phase change material operative to absorb thermal energy and change from an initial state of matter to a secondary state of matter in response to absorption of the thermal energy; the apparatus being characterized by one or more traces coupling the thermoelectric component with the one or more components, the one or more traces comprised of a thermal conductive material operative to thermally couple with the phase change material to transfer the absorbed thermal energy from the phase change material to the thermoelectric component and operative to convey the electrical energy from the thermoelectric component to the one or more components; and a printed circuit board, the one or more components disposed on the printed circuit board.
An illumination apparatus for a microscope for producing a de-excitation or switching light distribution, the illumination apparatus having a light source which is configured to produce a primary illumination light beam, the illumination apparatus comprising: a. a beam-splitting apparatus which is configured to divide the primary illumination light beam into two partial illumination light beams (7, 8), b. an illumination objective which is configured to focus the partial illumination light beams (7, 8) onto and/or into a sample, wherein the partial illumination light beams (7, 8) extend, spatially separated from one another, through an entry pupil of the illumination objective and are spatially superposed on and/or in the sample after passing through the illumination objective, and c. at least one phase-influencing means which is configured to cause a relative phase offset of the partial illumination light beams (7, 8) with respect to one another in such a way that the partial illumination light beams (7, 8) in the entry pupil of the illumination objective have a phase offset of π. a. a beam-splitting apparatus which is configured to divide the primary illumination light beam into two partial illumination light beams (7, 8), b. an illumination objective which is configured to focus the partial illumination light beams (7, 8) onto and/or into a sample, wherein the partial illumination light beams (7, 8) extend, spatially separated from one another, through an entry pupil of the illumination objective and are spatially superposed on and/or in the sample after passing through the illumination objective, and c. at least one phase-influencing means which is configured to cause a relative phase offset of the partial illumination light beams (7, 8) with respect to one another in such a way that the partial illumination light beams (7, 8) in the entry pupil of the illumination objective have a phase offset of π.
A method for inhibiting the polymerization of monomers in a composition comprising a polymerizable monomer or polymerizable monomer-forming compound, the method comprising: adding a hydroxylated quinone antipolymerant to a hydrocarbon composition comprising polymerizable monomer or capable of forming a polymerizable monomer, the antipolymerant being a compound of Formula I: wherein two or three of -R 1, -R 2, -R 3, and -R 4 are -OR 10, wherein R 10 is hydrogen, and one or two of -R 1, -R 2, -R 3, and -R 4 that is or are not -OR 10 is or are selected from the group consisting of hydrogen, alkyl, aryl, alkyl aryl, and aryl alkyl. adding a hydroxylated quinone antipolymerant to a hydrocarbon composition comprising polymerizable monomer or capable of forming a polymerizable monomer, the antipolymerant being a compound of Formula I: wherein two or three of -R 1, -R 2, -R 3, and -R 4 are -OR 10, wherein R 10 is hydrogen, and one or two of -R 1, -R 2, -R 3, and -R 4 that is or are not -OR 10 is or are selected from the group consisting of hydrogen, alkyl, aryl, alkyl aryl, and aryl alkyl.
Knee endoprosthesis comprising a tibia part, a femur part having two condylar surfaces (6,7), and a meniscus part arranged between the femur part and the tibia part, the meniscus part having on its upper side two bearing shells (9, 10) for receiving and mounting the condylar surfaces (6, 7) of the femur part and having on its underside a meniscus-bearing surface which rests in a displaceable manner on a tibia-bearing surface on the upper side of the tibia part, the meniscus-bearing surface and the tibia-bearing surface each having a projection or a recess offset in a medial or a lateral direction in relation to their center, and the projection on one of the two bearing surfaces (11, 4) engaging the recess of the other bearing surface (4, 11) and thereby forming a mounting of the meniscus part on the tibia part, wherein the projection and the recess are formed spherically, so that by engagement of the projection into the recess a ball bearing-like mounting of the meniscus part on the tibia part is formed, and wherein in the lateral or medial part of the two bearing surfaces (4, 11), these bearing surfaces form supporting areas (17, 21) bearing on each other, which are curved in a dorsal-ventral direction and have a radius of curvature there, which is greater than the radius of curvature of the spherical projection and the spherical recess by at least the factor 2.5.
Automated blast gel pack conditioning equipment (10, 32, 132, 232, 332) for phase change processing (i.e., freezing and/or melting material within gel packs) and conditioning gel packs, comprising: a housing defining a void space for containing a set of gel packs; at least one fan (44, 144) for circulating air within the housing such that a path of air flow extends through an air insufflation end to an air return end within the housing; wherein the equipment further comprises an evaporator for cooling air and a heater (14, 42) for heating air arranged within the housing; at least one temperature sensor located within the housing; and a controller for receiving temperature measurements from the at least one temperature sensor and for automatically controlling operation of the evaporator, heater (14, 42), and at least one fan (44, 144) within the housing during phase change processing and conditioning of gel packs, characterized in that the at least one temperature sensor includes at least one temperature sensor contained within a pot-shaped container filled with paraffin. a housing defining a void space for containing a set of gel packs; at least one fan (44, 144) for circulating air within the housing such that a path of air flow extends through an air insufflation end to an air return end within the housing; wherein the equipment further comprises an evaporator for cooling air and a heater (14, 42) for heating air arranged within the housing; at least one temperature sensor located within the housing; and a controller for receiving temperature measurements from the at least one temperature sensor and for automatically controlling operation of the evaporator, heater (14, 42), and at least one fan (44, 144) within the housing during phase change processing and conditioning of gel packs, characterized in that the at least one temperature sensor includes at least one temperature sensor contained within a pot-shaped container filled with paraffin.
Method for producing a connection between an electrode and an electrical conductor, comprising the following method steps: - guiding a conductor section of the conductor through a cutout in a part of the electrode, - folding over an electrode tab which is connected to an electrode surface and projects beyond the electrode surface, in such a way that the conductor section guided through the cutout lies between the electrode tab and the electrode surface, characterized in that an adhesive film applied to the electrode tab and projecting in between the electrode surface and a silicone layer on the electrode surface is folded over jointly with the electrode tab. - guiding a conductor section of the conductor through a cutout in a part of the electrode, - folding over an electrode tab which is connected to an electrode surface and projects beyond the electrode surface, in such a way that the conductor section guided through the cutout lies between the electrode tab and the electrode surface,
Gear housing for an aquatic vessel, said gear housing being adapted to be attached at an attachment site to an underside of a hull of said aquatic vessel, said gear housing comprising at least one weakened region (18, 78) adapted to yield when said gear housing is rotated at said attachment site following an impact, said gear housing comprising two side walls (32, 33) located opposite to one another so as to form a compartment wherein said weakened region (18, 78) is located extending from a second end towards a first end of the gear housing, the second end being situated in the longitudinal direction of the gear housing opposite to a first end of the gear housing which is exposed to receive the impact, said gear housing comprising a tail region where said side walls (32, 33) meet, which tail region is located at said second end, characterised by said weakened region comprising an slit dividing said tail region into a first and a second part (52, 53), said first part exhibiting an oblique surface facing an oblique surface on said second part such that said first and second parts (52, 53) are adapted to slide past one another in the event of an impact, said oblique surfaces (60, 61) being oriented at an oblique angle to an axis extending in a width direction or in a longitudinal direction of the gear housing.
A method of detecting a change in a surface of a wall, said method comprising the steps of: transmitting a pulse of input ultrasonic vibrations into a proximal surface of said wall, said pulse of input ultrasonic vibrations propagating through said wall and reflecting from a distal surface of said wall to form a current pulse of output ultrasonic vibrations at said proximal surface; receiving ultrasonic vibrations at said proximal surface; comparing said received ultrasonic vibrations with a previously detected pulse of output ultrasonic vibrations reflected from said distal surface of said wall and received at said proximal surface to detect changes in said surface of said wall. transmitting a pulse of input ultrasonic vibrations into a proximal surface of said wall, said pulse of input ultrasonic vibrations propagating through said wall and reflecting from a distal surface of said wall to form a current pulse of output ultrasonic vibrations at said proximal surface; receiving ultrasonic vibrations at said proximal surface; comparing said received ultrasonic vibrations with a previously detected pulse of output ultrasonic vibrations reflected from said distal surface of said wall and received at said proximal surface to detect changes in said surface of said wall.
A solid pharmaceutical formulation comprising a therapeutic agent and one or more pharmaceutically acceptable excipients, wherein the therapeutic agent is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide: or its salt, or a combination thereof, and wherein the one or more pharmaceutically acceptable excipients are selected from sodium starch glycolate, carmellose, carmellose calcium, croscarmellose sodium, low-substituted hydroxypropylcellulose, and a combination thereof.
Device for closing off a bay formed in a bodywork element of a motor vehicle, comprising a fixed part and at least one mobile panel relative to said fixed part, the sliding of which is guided by two rails (15 1, 15 2) carried by said fixed part, said mobile panel bearing two bolts (19 1, 19 2) capable of cooperating with two corresponding strikers, respectively formed in each of said rails (15 1, 15 2), and being mobile in a direction of unlocking perpendicular to the direction of sliding of said mobile panel, between a locked position in which said bolts (19 1, 19 2) are engaged with said strikers, and an unlocked position enabling sliding, in which said bolts (19 1, 19 2) are removed from said strikers, said mobile panel carrying an actuating handle for actuating said bolts (19 1, 19 2), that is mobile in one direction of actuation parallel to said direction of sliding, characterized in that said mobile panel carries angular gear transmission means (23 1, 23 2) implementing, for each bolt, a flexible leaf portion, a first end (232 1, 232 2) of which extends in parallel to said direction of unlocking and is fixed to said bolt (19 1, 19 2), and a second end (231 1, 231 2) of which extends in parallel to said direction of actuating and is fixed to said handle, means for guiding said leaf portion controlling the change in direction between said directions of unlocking and actuating.