mhurhangee/ep-ind-claims huggingface dataset:
A method of identifying a small-molecule candidate therapeutic capable of inhibiting or interfering with an intracellular target protein-protein interaction, the method comprising: (i) identifying a high affinity intracellular single domain antibody (iDab) that is associated with an intracellular protein-protein interaction, blockade of which has an effect on a disease or has an adverse biological effect; (ii) determining key contact residues involved in the intracellular protein-protein interaction between target protein and the high affinity iDab; (iii) engineering a derivative of the high affinity iDab based on the key contact residues to produce a de-matured affinity for binding to the target and reduced surface area of interaction with the target as compared with the starting variable domain, so as to bring the engineered iDab's binding affinity into a range required for potential competition with a small-molecule candidate therapeutic; (iv) contacting the protein target with the engineered iDab and a small-molecule candidate therapeutic and; (v) determining whether the small-molecule candidate is an emulator of engineered iDab. (i) identifying a high affinity intracellular single domain antibody (iDab) that is associated with an intracellular protein-protein interaction, blockade of which has an effect on a disease or has an adverse biological effect; (ii) determining key contact residues involved in the intracellular protein-protein interaction between target protein and the high affinity iDab; (iii) engineering a derivative of the high affinity iDab based on the key contact residues to produce a de-matured affinity for binding to the target and reduced surface area of interaction with the target as compared with the starting variable domain, so as to bring the engineered iDab's binding affinity into a range required for potential competition with a small-molecule candidate therapeutic; (iv) contacting the protein target with the engineered iDab and a small-molecule candidate therapeutic and; (v) determining whether the small-molecule candidate is an emulator of engineered iDab.
An artificial turf filament, wherein the filament (20; 30; 40; 45) has in cross-section: a central area (11; 46); and two wing areas (12, 13; 47,48) on opposite sides of said central area and integral with said central area, said wing areas (12, 13; 47, 48) being arranged in a diverging orientation, wherein each wing area is defined by opposed faces (12a, 12b, 13a, 13b; 47a, 47b, 48a, 48b), wherein at the outer side of the diverging wing areas (12,13; 47, 48) the central area (11; 46) has a face (11 a; 46a) which is essentially flush at the location of said central area (11; 46) and merges into the adjacent faces (12a, 13a; 47b, 48b) of each wing area (12, 13; 47, 48), and at the inner side of the diverging wing areas the central area (11; 46) forms an outwardly protruding bulb, preferably having a face (11 b; 46b) of a curved convex shape, so that said central area (11; 46) forms a protrusion with respect to the adjacent faces (12b,13b; 47c, 48c) of the wing areas (12, 13; 47, 48), characterized in that, the free end of each wing area has a rounded tip (12c, 13c; 47d, 48d) with an essentially circular cross-section having a diameter greater than the thickness of the part of the wing area adjoining said rounded tip. a central area (11; 46); and two wing areas (12, 13; 47,48) on opposite sides of said central area and integral with said central area, said wing areas (12, 13; 47, 48) being arranged in a diverging orientation, wherein each wing area is defined by opposed faces (12a, 12b, 13a, 13b; 47a, 47b, 48a, 48b), wherein at the outer side of the diverging wing areas (12,13; 47, 48) the central area (11; 46) has a face (11 a; 46a) which is essentially flush at the location of said central area (11; 46) and merges into the adjacent faces (12a, 13a; 47b, 48b) of each wing area (12, 13; 47, 48), and at the inner side of the diverging wing areas the central area (11; 46) forms an outwardly protruding bulb, preferably having a face (11 b; 46b) of a curved convex shape, so that said central area (11; 46) forms a protrusion with respect to the adjacent faces (12b,13b; 47c, 48c) of the wing areas (12, 13; 47, 48), characterized in that, the free end of each wing area has a rounded tip (12c, 13c; 47d, 48d) with an essentially circular cross-section having a diameter greater than the thickness of the part of the wing area adjoining said rounded tip.
A device for detecting an islanding condition in an electricity distribution network, characterized in that the device comprises: means configured to concurrently monitor an islanding condition and a network fault condition in the electricity distribution network; means configured to detect an islanding condition in the power system network; and means configured to determine that the detection of the islanding condition is invalid when there is a concurrent network fault associated with the detected islanding condition. means configured to concurrently monitor an islanding condition and a network fault condition in the electricity distribution network; means configured to detect an islanding condition in the power system network; and means configured to determine that the detection of the islanding condition is invalid when there is a concurrent network fault associated with the detected islanding condition.
A steel alloy composition, comprising: 0.36% to 0.60% by weight carbon; 0.30% to 0.70% by weight manganese; 0.001% to 0.017% by weight phosphorus; 0.15% to 0.60% by weight silicon; 1.40% to 2.25% by weight nickel; 0.85% to 1.60% by weight chromium; 0.70% to 1.10% by weight molybdenum; 0.010% to 0.030% by weight aluminum; 0.001% to 0.050% by weight zirconium; 0.0040% to 0.0090% by weight nitrogen; 0.02% to 0.10% by weight vanadium wherein the steel alloy composition optionally comprises 0.001% to 0.012% by weight phosphorus; or wherein the steel alloy composition optionally comprises 0.001% to 0.005% by weight phosphorus; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur, and a maximum of 0.35% by weight copper; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur, a maximum of 0.35% by weight copper. and a maximum of 0.020% by weight titanium; and a balance of iron. 0.36% to 0.60% by weight carbon; 0.30% to 0.70% by weight manganese; 0.001% to 0.017% by weight phosphorus; 0.15% to 0.60% by weight silicon; 1.40% to 2.25% by weight nickel; 0.85% to 1.60% by weight chromium; 0.70% to 1.10% by weight molybdenum; 0.010% to 0.030% by weight aluminum; 0.001% to 0.050% by weight zirconium; 0.0040% to 0.0090% by weight nitrogen; 0.02% to 0.10% by weight vanadium wherein the steel alloy composition optionally comprises 0.001% to 0.012% by weight phosphorus; or wherein the steel alloy composition optionally comprises 0.001% to 0.005% by weight phosphorus; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur, and a maximum of 0.35% by weight copper; or wherein the steel alloy composition optionally comprises a maximum of 0.025% by weight sulfur, a maximum of 0.35% by weight copper. and a maximum of 0.020% by weight titanium; and a balance of iron.
Machining cutting tool comprising: a body; a cutting insert (14, 30, 40); • a machining failure sensor (22, 32, 42) for the cutting insert (14, 30, 40), distinct from the cutting insert, configured to be removably mounted close to the cutting edge (14-1, 30-1) of the insert and set back relative to the cutting edge, the sensor being made out of an electrically conductive material coated with an insulator in the vicinity of the cutting edge so as to isolate the sensor, once mounted, from the body of the cutting tool and the insert, and comprising an uninsulated zone (24, 32-3, 42-2) remote from the cutting edge and forming an electrical connection terminal; and characterized by: • a continuity detection circuit directly connected between the connecting terminal (24, 32-3, 42-2) of the sensor and the body of the tool. a body; a cutting insert (14, 30, 40); • a machining failure sensor (22, 32, 42) for the cutting insert (14, 30, 40), distinct from the cutting insert, configured to be removably mounted close to the cutting edge (14-1, 30-1) of the insert and set back relative to the cutting edge, the sensor being made out of an electrically conductive material coated with an insulator in the vicinity of the cutting edge so as to isolate the sensor, once mounted, from the body of the cutting tool and the insert, and comprising an uninsulated zone (24, 32-3, 42-2) remote from the cutting edge and forming an electrical connection terminal; and • a machining failure sensor (22, 32, 42) for the cutting insert (14, 30, 40), distinct from the cutting insert, configured to be removably mounted close to the cutting edge (14-1, 30-1) of the insert and set back relative to the cutting edge, the sensor being made out of an electrically conductive material coated with an insulator in the vicinity of the cutting edge so as to isolate the sensor, once mounted, from the body of the cutting tool and the insert, and comprising an uninsulated zone (24, 32-3, 42-2) remote from the cutting edge and forming an electrical connection terminal; and characterized by: • a continuity detection circuit directly connected between the connecting terminal (24, 32-3, 42-2) of the sensor and the body of the tool. • a continuity detection circuit directly connected between the connecting terminal (24, 32-3, 42-2) of the sensor and the body of the tool.
Hydraulic motor with a casing which has a first and a second working port, wherein there is a rotor inside the casing which is rotatable with about an axis with respect to the casing, wherein the rotor has a plurality of movable pistons, wherein there is a distributor located fixed inside the casing which has an end face, wherein the rotor abuts against the end face, wherein there is a first and a third chamber which are delimited by the distributor and the casing respectively, wherein the first chamber is permanently connected to a plurality of first openings in the end face, wherein the third chamber is permanently connected to a plurality of second openings in the end face, wherein the first chamber is permanently connected to the first working port, wherein the casing has a third working port, wherein there is a second and a fourth chamber which are delimited by the casing and the distributor respectively, wherein the second chamber is permanently connected to the second working port, wherein the fourth chamber is permanently connected to the third working port, wherein there is a movable spool located inside the casing, which has a first and a second position (82; 83), wherein in the first position there is a connection from the third chamber to the second chamber via the spool, characterized in that the second position there is a connection from the third chamber to the fourth chamber via the spool and a connection from the first chamber to the second chamber via the spool, wherein the casing has a drain channel which connects the spool to an interior of the casing. wherein the casing has a third working port, wherein there is a second and a fourth chamber which are delimited by the casing and the distributor respectively, wherein the second chamber is permanently connected to the second working port, wherein the fourth chamber is permanently connected to the third working port, wherein there is a movable spool located inside the casing, which has a first and a second position (82; 83), wherein in the first position there is a connection from the third chamber to the second chamber via the spool, characterized in that the second position there is a connection from the third chamber to the fourth chamber via the spool and a connection from the first chamber to the second chamber via the spool, wherein the casing has a drain channel which connects the spool to an interior of the casing.
A recommendation engine for a lighting system comprising: - a recommendation component for generating recommendation messages to recommend lighting effects for the lighting system; - at least one data input for receiving, from a data source, data pertaining to a user of the lighting system; characterised in that the recommendation engine further comprises: - a receptiveness component configured to use the received data to compute a current receptiveness level for the user indicating a current receptiveness of the user to receiving recommendations; wherein the recommendation component is configured to selectively cause recommendation messages to be outputted to the user via a user interface, such that recommendation messages are outputted to the user when the current receptiveness level exceeds a threshold and such that recommendation messages are otherwise suppressed. - a recommendation component for generating recommendation messages to recommend lighting effects for the lighting system; - at least one data input for receiving, from a data source, data pertaining to a user of the lighting system; characterised in that the recommendation engine further comprises: - a receptiveness component configured to use the received data to compute a current receptiveness level for the user indicating a current receptiveness of the user to receiving recommendations; - a receptiveness component configured to use the received data to compute a current receptiveness level for the user indicating a current receptiveness of the user to receiving recommendations;
A method for obtaining Quality of Service, QoS, information of a session, comprising: configuring a policy used for analyzing QoS of a session; extracting a control message of the session during the session; obtaining QoS information of the session according to the policy used for analyzing the QoS of the session; wherein the QoS information of the session is obtained from information carried in the control message; characterized in that the policy is configured on a Signaling Proxy, SP, the SP determines whether it is necessary to make a QoS analysis on the established session according to the configured policy information, and when determining that it is necessary to make a QoS analysis on the session, the SP sends an instruction to an Media Proxy, MP, to instruct the MP to make a QoS analysis on the session. configuring a policy used for analyzing QoS of a session; extracting a control message of the session during the session; obtaining QoS information of the session according to the policy used for analyzing the QoS of the session; wherein the QoS information of the session is obtained from information carried in the control message; characterized in that the policy is configured on a Signaling Proxy, SP, the SP determines whether it is necessary to make a QoS analysis on the established session according to the configured policy information, and when determining that it is necessary to make a QoS analysis on the session, the SP sends an instruction to an Media Proxy, MP, to instruct the MP to make a QoS analysis on the session.
A developing cartridge comprising: a casing configured to accommodate developing agent therein, the casing including one end portion and another end portion spaced apart from the one end portion in a first direction; a developing roller rotatable about a developing roller axis extending in the first direction; and a first cam positioned at the one end portion of the casing, the first cam being movable relative to the casing and the developing roller in the first direction between a first position and a second position, the first cam in the second position being positioned closer to the another end portion of the casing in the first direction than the first cam in the first position is to the another end portion of the casing; a second cam positioned at the another end portion of the casing, the second cam being movable relative to the casing and the developing roller in the first direction between a third position and a fourth position, the second cam in the fourth position being positioned closer to the another end portion of the casing in the first direction than the second cam in the third position is to the another end portion of the casing; and a connection member connecting the first cam and the second cam to each other, characterized in that the second cam is movable from the third position to the fourth position due to a tensile force of the connection member in accordance with movement of the first cam from the first position to the second position. a casing configured to accommodate developing agent therein, the casing including one end portion and another end portion spaced apart from the one end portion in a first direction; a developing roller rotatable about a developing roller axis extending in the first direction; and a first cam positioned at the one end portion of the casing, the first cam being movable relative to the casing and the developing roller in the first direction between a first position and a second position, the first cam in the second position being positioned closer to the another end portion of the casing in the first direction than the first cam in the first position is to the another end portion of the casing; a second cam positioned at the another end portion of the casing, the second cam being movable relative to the casing and the developing roller in the first direction between a third position and a fourth position, the second cam in the fourth position being positioned closer to the another end portion of the casing in the first direction than the second cam in the third position is to the another end portion of the casing; and a connection member connecting the first cam and the second cam to each other, characterized in that the second cam is movable from the third position to the fourth position due to a tensile force of the connection member in accordance with movement of the first cam from the first position to the second position.
A mobile communication device comprising a radio transceiver and a baseband processing circuit adapted to interact with the radio transceiver to transmit and receive radio signals, the baseband processing circuit configured to: provide target criteria to a proxy discovery device, the target criteria characterizing a desired wireless connection of the mobile communication device and; receive a proxy report from the proxy discovery device detailing discovery results that satisfy the target criteria, wherein the baseband processing circuit of the mobile communication device is configured to arrange with the proxy discovery device a specific time window and is configured to be provided by the proxy discovery device with a specific carrier channel, wherein the proxy discovery device is scheduled to transmit the proxy report, during the specific time window and on the specific carrier channel, to the mobile communication device, said specific time window corresponding to an awake state of the mobile communication device to receive the proxy report, wherein the mobile communication device enters a low-power state during other times; and select a provider device that satisfies the target criteria to establish a wireless connection with based on the proxy report. provide target criteria to a proxy discovery device, the target criteria characterizing a desired wireless connection of the mobile communication device and; receive a proxy report from the proxy discovery device detailing discovery results that satisfy the target criteria, wherein the baseband processing circuit of the mobile communication device is configured to arrange with the proxy discovery device a specific time window and is configured to be provided by the proxy discovery device with a specific carrier channel, wherein the proxy discovery device is scheduled to transmit the proxy report, during the specific time window and on the specific carrier channel, to the mobile communication device, said specific time window corresponding to an awake state of the mobile communication device to receive the proxy report, wherein the mobile communication device enters a low-power state during other times; and select a provider device that satisfies the target criteria to establish a wireless connection with based on the proxy report.
A user equipment, characterised by: means for determining (502; 606) a discontinuous reception, DRX, gap length; means for selecting, from a plurality of power reduction techniques, a power reduction technique associated with the determined DRX gap length; and means for powering down one or more components of a receiver circuit during the DRX gap according to the selected power reduction technique. means for determining (502; 606) a discontinuous reception, DRX, gap length; means for selecting, from a plurality of power reduction techniques, a power reduction technique associated with the determined DRX gap length; and means for powering down one or more components of a receiver circuit during the DRX gap according to the selected power reduction technique.
A thermoplastic transparent resin obtained by hydrogenating terminal double bonds and 70% or more of aromatic double bonds of a copolymer, wherein the copolymer is produced by polymerizing a monomer composition consisting essentially of at least one (meth)acrylic ester monomer and styrene; wherein the copolymer has a molar ratio A/B of from 1 to 4 wherein A is the molar amount of the constitutional unit derived from the (meth)acrylic ester monomer and B is the molar amount of the constitutional unit derived from styrene; and wherein the (meth)acrylic ester monomer is a sole alkyl methacrylate or a combination of alkyl methacrylate and alkyl acrylate.
A device for safeguarding a monitoring area in which an automatically operating machine is arranged, having a camera system for monitoring the monitoring area, having a configuration unit for defining at least one protection area within the monitoring area, and having an analysis unit for triggering a safety-related function, wherein the camera system supplies camera images of the protection area and the analysis unit analyzes whether a foreign object is present in the protection area or penetrates into the protection area, wherein the analysis unit is furthermore configured to classify a foreign object, which is present in the protection area or penetrates into the protection area, by analysis of the camera images, to determine on the basis of one or more features characteristic for non-safety-critical objects whether the foreign object is a non-safety-critical object, and wherein the analysis unit is configured to trigger the safety-related function if the foreign object has not been recognized as a non-safety-critical object, characterized in that the non-safety-critical objects comprise welding sparks and the analysis unit is configured to determine, in at least one of the camera images, a spatial distribution (56, 56') of grayscale values in an image region of a detected foreign object, to determine on the basis thereof whether the foreign object is a welding spark.