mhurhangee/ep-ind-claims huggingface dataset:
An IL-11Rα-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds to IL-11Rα and inhibits IL-11-mediated proliferation of BaF3 cells expressing IL-11Rα and gp130, and wherein: (i) the antigen binding domain binds to an epitope comprising residues between amino acids 111-215 of SEQ ID NO: 1; (ii) the antigen binding domain comprises a V H comprising the sequence: wherein: X 1 = S, A, G or W; X 2 = W or R; X 3 = Y, W or F; X 4 = M, I, V, T or L; X 5 = T or A; X 6 = S, W, Y, or H; X 7 = G or A; X 8 = G, D or T; X 9 = H, Y, L, I or F; X 10 = G or P; X 11 = P, E, V, L, N or H; X 12 = G or D; X 13 = S, M, R, L, Q or T; X 14 = D, A or W; and X 15 = L, V, F, Q, E, Y or T; (iii) the antigen binding domain comprises a V L comprising the sequence: wherein X 1 = I or V; X 2 = N, D, G, S, A or H; X 3 = N, Y, I, K, M, Q, G or H; X 4 = Y or W; X 5 = L, V, I, or M; X 6 = N or E; X 7 = Q, E, S, or T; X 8 = Y, A, H, F, N, S, or W; X 9 = D or E; X 10 = N, D, F, S, E or T; X 11 = L or Q; X 12 = S, A, W, T, M or Q; and X 13 = T, E, F, A, L, N, or Q; and (iv) the antigen binding domain comprises a V H sequence at least about 95%, or 96%, or 97% or 98% or 99% identical to a sequence set forth in SEQ ID NO: 37 and the antigen binding domain comprises a V L sequence at least about 94% or 95%, or 96%, or 97%, or 98%, or 99% identical to a sequence set forth in SEQ ID NO: 5. (i) the antigen binding domain binds to an epitope comprising residues between amino acids 111-215 of SEQ ID NO: 1; (ii) the antigen binding domain comprises a V H comprising the sequence: wherein: X 1 = S, A, G or W; X 2 = W or R; X 3 = Y, W or F; X 4 = M, I, V, T or L; X 5 = T or A; X 6 = S, W, Y, or H; X 7 = G or A; X 8 = G, D or T; X 9 = H, Y, L, I or F; X 10 = G or P; X 11 = P, E, V, L, N or H; X 12 = G or D; X 13 = S, M, R, L, Q or T; X 14 = D, A or W; and X 15 = L, V, F, Q, E, Y or T; (iii) the antigen binding domain comprises a V L comprising the sequence: wherein X 1 = I or V; X 2 = N, D, G, S, A or H; X 3 = N, Y, I, K, M, Q, G or H; X 4 = Y or W; X 5 = L, V, I, or M; X 6 = N or E; X 7 = Q, E, S, or T; X 8 = Y, A, H, F, N, S, or W; X 9 = D or E; X 10 = N, D, F, S, E or T; X 11 = L or Q; X 12 = S, A, W, T, M or Q; and X 13 = T, E, F, A, L, N, or Q; and (iv) the antigen binding domain comprises a V H sequence at least about 95%, or 96%, or 97% or 98% or 99% identical to a sequence set forth in SEQ ID NO: 37 and the antigen binding domain comprises a V L sequence at least about 94% or 95%, or 96%, or 97%, or 98%, or 99% identical to a sequence set forth in SEQ ID NO: 5.
Blood treatment device for an extracorporeal blood treatment comprising a dialyser which is subdivided by a semipermeable membrane into a blood chamber, which can be flowed through by blood at a predetermined blood flow Q b, and a dialysate chamber, which can be flowed through by dialysate at a predetermined dialysate flow Q d, an arterial blood line leading to the blood chamber and a venous blood line leaving the blood chamber and a dialysate supply line leading to the dialysate chamber and a dialysate removal line leaving the dialysate chamber, a device for determining an optimum dialysate flow Q dopt for the extracorporeal blood treatment, comprising a calculation and/or evaluation unit and a measurement device for measuring at least one value which is characteristic of the clearance K, the calculation and/or evaluation unit being configured in such a way that the clearance is determined on the basis of the at least one value which is characteristic of the clearance, and the calculation and/or evaluation unit being configured in such a way that the optimum dialysate flow Q dopt is determined from a relationship describing the dependence of the clearance on the dialysate rate on the basis of the measured clearance K or the optimum dialysate flow Q dopt is determined from at least one measured clearance K, characterised in that the blood treatment device comprises a valve arrangement which is formed in such a way that a flow connection between the arterial blood line and the venous blood line can be established for measuring the clearance K at a predetermined blood flow rate Q b and a predetermined dialysate rate Q d.
An antibody that binds human Gro-alpha, Gro-beta, Gro-gamma, ENA-78, GCP-2, NAP-2, and IL-8, the antibody comprising a light chain and a heavy chain, wherein the light chain comprises a light chain variable region (LCVR) and the heavy chain comprises a heavy chain variable region (HCVR), wherein the LCVR comprises LCDR1, LCDR2, LCDR3 and the HCVR comprises HCDR1, HCDR2, HCDR3, wherein LCDR1 is RASQSISNNLH (SEQ ID NO: 7), LCDR2 is YTSRSVS (SEQ ID NO: 8), LCDR3 is GQNNEWPEV (SEQ ID NO: 9), HCDR1 is GYEFTSYWIH (SEQ ID NO: 10), HCDR2 is NISPNSGSANYNEKFKS (SEQ ID NO: 11), and HCDR3 is EGPYSYYPSRXaaYYGSDL (SEQ ID NO: 20) wherein Xaa is E or Q.
A magnetic fluid sealed bearing, comprising: a bearing body, the bearing body including an inner ring, an outer ring, and a plurality of rolling members interposed between the inner ring and the outer ring; a pair of ring-shaped magnets (112A, 112B) disposed in an annular space between the inner ring and the outer ring, the pair of ring-shaped magnets (112A, 112B) being disposed on each side of the bearing body in an axial direction with the rolling members interposed therebetween; a polar plate (114A, 114B) retaining each of the pair of magnets (112A, 112B); and magnetic fluid (m) retained by a magnetic circuit formed by the pair of magnets (112A, 112B) to seal the rolling members, wherein the pair of magnets (112A, 112B) are magnetized such that magnetic poles point in the axial direction of the bearing body, and opposing sides of the pair of magnets (112A, 112B) have different magnetic polarities from each other, the magnetic fluid (m) is disposed at least between the polar plate (114A, 114B) and an inner circumferential surface of the outer ring or between the polar plate (114A, 114B) and an outer circumferential surface of the inner ring, characterized in that a magnetic force generated by the pair of magnets (112A, 112B) and acting on the rolling members is larger in the axial direction than that in a radial direction of the bearing body, and an axial component of a magnetic flux penetrating the rolling members is three or more times as large as a radial component thereof. a bearing body, the bearing body including an inner ring, an outer ring, and a plurality of rolling members interposed between the inner ring and the outer ring; a pair of ring-shaped magnets (112A, 112B) disposed in an annular space between the inner ring and the outer ring, the pair of ring-shaped magnets (112A, 112B) being disposed on each side of the bearing body in an axial direction with the rolling members interposed therebetween; a polar plate (114A, 114B) retaining each of the pair of magnets (112A, 112B); and magnetic fluid (m) retained by a magnetic circuit formed by the pair of magnets (112A, 112B) to seal the rolling members, wherein the pair of magnets (112A, 112B) are magnetized such that magnetic poles point in the axial direction of the bearing body, and opposing sides of the pair of magnets (112A, 112B) have different magnetic polarities from each other, the magnetic fluid (m) is disposed at least between the polar plate (114A, 114B) and an inner circumferential surface of the outer ring or between the polar plate (114A, 114B) and an outer circumferential surface of the inner ring, characterized in that a magnetic force generated by the pair of magnets (112A, 112B) and acting on the rolling members is larger in the axial direction than that in a radial direction of the bearing body, and an axial component of a magnetic flux penetrating the rolling members is three or more times as large as a radial component thereof.
A method for use in connection with installing a fibre into a conduit having a first end and a second end, the method being suitable to detect when the fibre introduced into the first end arrives at the second end, and comprising the steps of: - introducing the fibre into the conduit from the first end and installing it towards the second end; - introducing light with a light source into the fibre at the first end; - detecting reflected light caused by reflection of the light from a cleaved end of the fibre, with a light detector at the first end; and - detecting a change in the reflected light, whereby an operator may determine that the fibre has arrived at the second end, the detected change in the reflected light being a drop in the amount of reflected light, wherein the change in the reflected light is caused by immersion of the cleaved end of the fibre into an index matching fluid. - introducing the fibre into the conduit from the first end and installing it towards the second end; - introducing light with a light source into the fibre at the first end; - detecting reflected light caused by reflection of the light from a cleaved end of the fibre, with a light detector at the first end; and - detecting a change in the reflected light, whereby an operator may determine that the fibre has arrived at the second end, the detected change in the reflected light being a drop in the amount of reflected light, wherein the change in the reflected light is caused by immersion of the cleaved end of the fibre into an index matching fluid.
A power distribution rack assembly comprising: a manifold having an outer surface and defining an interior having a set of slots adapted to receive a set of electronic cards; a set of bus bar channels disposed in the outer surface of a wall of the manifold normal to the set of slots and having a set of apertures through the wall; a set of bus bar segments configured to be received in the set of bus bar channels and having at least one end that couples with a power source; and a set of electrical contacts coupled with the set of bus bar segments, wherein the set of electrical contacts extend from the outer surface of the wall through the set of apertures to the interior of the manifold and couple with a set of electronic cards received in the set of slots when the set of bus bar segments are received in the set of bus bar channels; wherein the set of bus bar segments is selected and arranged in the set of bus bar channels to couple with a selected set of electronic cards received in the set of slots.
A sole structure for an article of footwear having an upper, the sole structure comprising: a first plate having a first surface facing away from the upper, the first plate including a forefoot region at an anterior end of the first plate, a heel region at a posterior end of the first plate, and a mid-foot region intermediate the forefoot region and the heel region; a second plate having (i) a second surface opposing the first surface of the first plate and (ii) a first end attached at the forefoot region of the first plate, the second plate extending from the first end to a second end that is spaced apart from the first surface of the first plate; a cushion disposed between the first plate and the second plate in the forefoot region and having a first side attached to the first surface of the first plate and a second side attached to the second surface of the second plate, the cushion extending from a medial side of the sole structure to a lateral side of the sole structure; a heel pad attached to the second surface of the first plate at the posterior end; and a heel plate attached to the heel pad; wherein the second plate and the heel plate cooperate to define a ground-engaging surface of the sole structure which is configured to contact a ground during operation, and the cushion comprises a fluid-filled bladder and the fluid-filled bladder includes a tensile member disposed therein. a first plate having a first surface facing away from the upper, the first plate including a forefoot region at an anterior end of the first plate, a heel region at a posterior end of the first plate, and a mid-foot region intermediate the forefoot region and the heel region; a second plate having (i) a second surface opposing the first surface of the first plate and (ii) a first end attached at the forefoot region of the first plate, the second plate extending from the first end to a second end that is spaced apart from the first surface of the first plate; a cushion disposed between the first plate and the second plate in the forefoot region and having a first side attached to the first surface of the first plate and a second side attached to the second surface of the second plate, the cushion extending from a medial side of the sole structure to a lateral side of the sole structure; a heel pad attached to the second surface of the first plate at the posterior end; and a heel plate attached to the heel pad; wherein the second plate and the heel plate cooperate to define a ground-engaging surface of the sole structure which is configured to contact a ground during operation, and the cushion comprises a fluid-filled bladder and the fluid-filled bladder includes a tensile member disposed therein.
Transmission device for an injection valve, which transmission device transmits a deflection of an actuator, having a housing which has a first recess in which a first and second piston (6, 7) are mounted in movable fashion, and the first and the second piston (6, 7) are operatively connected by means of a fluid via at least one transmitter chamber (10, 11), wherein the operative connection effects a displacement of the second piston when the first piston is moved and vice versa, wherein the transmitter chamber (10, 11) is hydraulically connected via a sealing gap to an equalization chamber, which sealing gap compensates pressure differences between the transmitter chamber (10, 11) and the equalization chamber with a delay, and having a chamber device with a chamber which has a chamber housing which has a recess, with a piston and with a device, which has the following features: a first body, which has a recess, a second body, which is inserted into the recess, and an elastomer, which is introduced between the first and second body into the recess and thus closes and seals off, in said region, the intermediate space between the first and the second body, wherein the elastomer has a first groove which extends, spaced apart from the wall of the recess, at least partially along the recess, wherein the regions of the first and second body against which the elastomer bears are free from edges, and wherein the chamber is the equalization chamber, the chamber housing is the housing and the piston is the first piston, characterized in that a second groove is formed in the elastomer, which second groove runs radially within the first groove, and in that first groove is deeper than the second groove.
A process for making a curable resin composition comprising the steps of: reacting a) an isocyanate; and b) a polyol mixture with a bimodal distribution of i) a first polyol mixture comprising polyols having an average equivalent weight of from 50 to 400; and ii) a second polyol mixture comprising polyols having an average equivalent weight of from 2000 to 5000; to form a urethane prepolymer; and adding a capping agent to the urethane prepolymer to form the curable resin composition. reacting a) an isocyanate; and b) a polyol mixture with a bimodal distribution of i) a first polyol mixture comprising polyols having an average equivalent weight of from 50 to 400; and ii) a second polyol mixture comprising polyols having an average equivalent weight of from 2000 to 5000; to form a urethane prepolymer; and a) an isocyanate; and b) a polyol mixture with a bimodal distribution of i) a first polyol mixture comprising polyols having an average equivalent weight of from 50 to 400; and ii) a second polyol mixture comprising polyols having an average equivalent weight of from 2000 to 5000; i) a first polyol mixture comprising polyols having an average equivalent weight of from 50 to 400; and ii) a second polyol mixture comprising polyols having an average equivalent weight of from 2000 to 5000; adding a capping agent to the urethane prepolymer to form the curable resin composition.
A battery module comprising a plurality of sequentially stacked plate-shaped battery cells and two or more heat dissipation members, characterized in that a first heat dissipation member extends such that one side of the first heat dissipation member at least partially covers one outermost battery cell (a) of the battery module, and another side of the first heat dissipation member is interposed between the inside battery cells, and a second heat dissipation member extends such that one side of the second heat dissipation member at least partially covers the outermost battery cell (a) while the second heat dissipation member is not overlapped with the first heat dissipation member, and the other side of the second heat dissipation member is interposed between the inside battery cells, and in that the one side of the first heat dissipation member covers 1/3 to 1/2 of an outer surface of the outermost battery cell (a), and the one side of the second heat dissipation member covers 1/3 to 1/2 of the outer surface of the outermost battery cell (a) while the one side of the second heat dissipation member is opposite to the one side of the first heat dissipation member.
A method in a Proxy-Call Session Control Function, P-CSCF, for selecting a media gateway node for an IP session, the method comprising: receiving one or more Session Initiation Protocol, SIP, packets originating from a wireless device as part of the IP session; responsive to receiving the SIP packets, transmitting a request to a Policy Control Function, PCF, for an indication of a geographical service area for a User Plane Function, UPF associated with the IP session; receiving an indication of the geographical service area; and selecting a gateway node based on the geographical service area. receiving one or more Session Initiation Protocol, SIP, packets originating from a wireless device as part of the IP session; responsive to receiving the SIP packets, transmitting a request to a Policy Control Function, PCF, for an indication of a geographical service area for a User Plane Function, UPF associated with the IP session; receiving an indication of the geographical service area; and selecting a gateway node based on the geographical service area.
A magnetic position detector comprising at least one pair of magnetic sensors (SV-GMR1 to SV-GMR4, H1 to H4) and a plurality of magnetic members (1a to 1e) which are arranged along an arrangement direction and whose magnetic pole faces are face to face with the magnetic sensors; wherein each of the magnetic pole faces face to face with the magnetic sensors has a different magnetic polarity than any neighboring magnetic pole face, and each magnetic member is arranged separate from any neighboring magnetic member, and wherein the magnetic sensors are located at the same position in the arrangement direction of the magnetic members, and are adapted to output signals (Voutl; Vout2) of two phases, so that a relative position of the magnetic members and the magnetic sensors can be uniquely identified.
Method of determining the mean surface radius r D and/or the particle density n D of a powder in a sample levitated in a plasma of volume V formed between a first electrode supplied with a radiofrequency voltage and a second electrode carried at a constant voltage, notably ground, characterised in that: n D = 1 4 πK 2 V ⁢ Δ A B × 1 V RF − 1 V RF 0 2 ⁢ n r D = K Δ A B 1 V RF − 1 V RF 0 n with: K = ε 0 C qV D n, Δ A B = δ t δ 0 − 1 1 A M 0 + 1 A B 0, δ t = π arccos V DC V RF − 1 and δ 0 = π arccos V DC 0 V RF 0 − 1 V RF designates the amplitude at the measurement instant t of the radiofrequency RF voltage supplying the first electrode when the powder is present in the plasma, where the instant t = 0 corresponds to the absence of powder in the plasma, V RF designates the amplitude of said radiofrequency voltage supplying the first electrode in the absence of powder in the plasma, V DC designating the self-bias voltage of the first electrode at the instant t when the powder is present in the plasma, V DC designating the self-bias voltage of the first electrode in the absence of powder in the plasma, ΔA B designating the surface variation of the second electrode in the presence of powder at the instant t relative to a situation in the absence of powder, A B0 and A M0 designating the effective surface of the electrodes in the absence of powder, and the values of n and K being determined by calibration by plotting a curve showing r D as a function of ΔA B and V RF based on experimental data obtained on the basis of the powders having a known particle diameter by measuring V RF, V RF, V DC, and V DC and by performing regression on said curve. V RF designates the amplitude at the measurement instant t of the radiofrequency RF voltage supplying the first electrode when the powder is present in the plasma, where the instant t = 0 corresponds to the absence of powder in the plasma, V RF designates the amplitude of said radiofrequency voltage supplying the first electrode in the absence of powder in the plasma, V DC designating the self-bias voltage of the first electrode at the instant t when the powder is present in the plasma, V DC designating the self-bias voltage of the first electrode in the absence of powder in the plasma, ΔA B designating the surface variation of the second electrode in the presence of powder at the instant t relative to a situation in the absence of powder, A B0 and A M0 designating the effective surface of the electrodes in the absence of powder, and the values of n and K being determined by calibration by plotting a curve showing r D as a function of ΔA B and V RF based on experimental data obtained on the basis of the powders having a known particle diameter by measuring V RF, V RF, V DC, and V DC and by performing regression on said curve.
A composition chosen from a nutritional supplement, a dietary supplement, a food supplement, a pharmaceutical grade supplement, and a medical food, comprising: at least 30% of the omega-3 fatty acid docosahexaenoic acid, by weight of the total fatty acids in the composition in a form chosen from ethyl ester, free fatty acid, and triglyceride; and an omega-6 fatty acid; wherein the weight ratio of the omega-3 fatty acid to the omega-6 fatty acid is about 10:1 or greater, for use in enhancing or prolonging fertility in a female human. at least 30% of the omega-3 fatty acid docosahexaenoic acid, by weight of the total fatty acids in the composition in a form chosen from ethyl ester, free fatty acid, and triglyceride; and an omega-6 fatty acid; wherein the weight ratio of the omega-3 fatty acid to the omega-6 fatty acid is about 10:1 or greater, for use in enhancing or prolonging fertility in a female human.