A tissue sample array comprising colorectal cancer tissue samples, wherein the array is labeled with an antibody that specifically binds pan-cytokeratin in normal and tumor tissue, an antibody that specifically binds vimentin, an antibody that specifically binds TEM1, an antibody that specifically binds fibronectin-1, an antibody that specifically binds collagen IV, an antibody that specifically binds CD31, and an antibody that specifically binds HIF2α, wherein the array comprises: a plurality of tissue samples labeled with the antibody that specifically binds vimentin, a plurality of tissue samples labeled with the antibody that specifically binds pan-cytokeratin and the antibody that specifically binds CD31, a plurality of tissue samples labeled with the antibody that specifically binds vimentin and the antibody that specifically binds CD31, and a plurality of tissue samples labeled with the antibody that specifically binds pan-cytokeratin, and wherein at least one tissue sample labeled with the antibody that specifically binds vimentin is also labeled with the antibody that specifically binds TEM-1, at least one tissue sample labeled with the antibody that specifically binds pan-cytokeratin and the antibody that specifically binds CD31 is also labeled with the antibody that specifically binds TEM-1, at least one tissue sample labeled with the antibody that specifically binds vimentin and the antibody that specifically binds CD31 is also labeled with the antibody that specifically binds HIF2α, at least one tissue sample labeled with the antibody that specifically binds pan-cytokeratin is also labeled with the antibody that specifically binds collagen IV, and at least one tissue sample labeled with the antibody that specifically binds vimentin is also labeled with the antibody that specifically binds fibronectin-1. a plurality of tissue samples labeled with the antibody that specifically binds vimentin, a plurality of tissue samples labeled with the antibody that specifically binds pan-cytokeratin and the antibody that specifically binds CD31, a plurality of tissue samples labeled with the antibody that specifically binds vimentin and the antibody that specifically binds CD31, and a plurality of tissue samples labeled with the antibody that specifically binds pan-cytokeratin, and wherein at least one tissue sample labeled with the antibody that specifically binds vimentin is also labeled with the antibody that specifically binds TEM-1, at least one tissue sample labeled with the antibody that specifically binds pan-cytokeratin and the antibody that specifically binds CD31 is also labeled with the antibody that specifically binds TEM-1, at least one tissue sample labeled with the antibody that specifically binds vimentin and the antibody that specifically binds CD31 is also labeled with the antibody that specifically binds HIF2α, at least one tissue sample labeled with the antibody that specifically binds pan-cytokeratin is also labeled with the antibody that specifically binds collagen IV, and at least one tissue sample labeled with the antibody that specifically binds vimentin is also labeled with the antibody that specifically binds fibronectin-1.