mhurhangee/ep-ind-claims huggingface dataset:
Zafirlukast, a metabolite, or a pharmaceutically acceptable salt or ester thereof, for use as a bactericidal agent in the treatment of a Gram-positive bacterial infection, wherein: the bacterial infection is an infection selected from the group consisting of a Staphylococcus spp., an Enterococcus spp., a Bacillus spp., a Streptococcus spp. and a Clostridium spp. infection; and said metabolite of zafirlukast is selected from the group consisting of: N-[4-(5-Amino-1-methyl-1H-indol-3-ylmethyl)-3-methoxybenzoyl]-2-methyl-benzenesulfonamide, N-[3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1H-indol-5-yl]acetamide, N-[1-Hydroxymethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-5-yl]acetamide, N-[3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1-methyl-1H-indol-5-yl]acetamide, [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-IH-indol-5-yl]carbamic acid cyclopentyl ester, [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1-methyl-lH-indol-5-yl]carbamic acid hydroxycyclopentyl ester, [1-Hydroxymethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-5-yl]carbamic acid cyclopentyl ester and [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1H-indol-5-yl]carbamic acid hydroxycyclopentyl ester. the bacterial infection is an infection selected from the group consisting of a Staphylococcus spp., an Enterococcus spp., a Bacillus spp., a Streptococcus spp. and a Clostridium spp. infection; and said metabolite of zafirlukast is selected from the group consisting of: N-[4-(5-Amino-1-methyl-1H-indol-3-ylmethyl)-3-methoxybenzoyl]-2-methyl-benzenesulfonamide, N-[3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1H-indol-5-yl]acetamide, N-[1-Hydroxymethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-5-yl]acetamide, N-[3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1-methyl-1H-indol-5-yl]acetamide, [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-IH-indol-5-yl]carbamic acid cyclopentyl ester, [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1-methyl-lH-indol-5-yl]carbamic acid hydroxycyclopentyl ester, [1-Hydroxymethyl-3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-5-yl]carbamic acid cyclopentyl ester and [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)benzyl]-1H-indol-5-yl]carbamic acid hydroxycyclopentyl ester.
Use of a short interfering nucleic acid (siNA) which causes RNA interference of Interleukin 12 (IL-12) in the preparation of a medicament for the treatment of inflammatory bowel disease, wherein the siNA is administered intrarectally to a patient and said RNA interference occurs in intestinal tissue but not in bladder, kidney. lung, ovary or liver tissue.
An uplink transmission method for use in an UE, wherein the uplink transmission method comprises: detecting an Uplink, UL, grant on a target time-domain resource and a target frequency-domain resource in a first time unit, the UL grant being to schedule one or more User Equipments, UEs, to perform uplink transmission in a target time unit, the first time unit and the target time unit each having a predefined length of B2 symbols, and the predefined length is less than a length of a subframe, where B2 is an integer greater than or equal to 1; acquiring scheduling information for the UE in the target time unit from the UL grant, wherein the scheduling information indicates sizes and positions of a time-domain resource and a frequency-domain resource for the uplink transmission for the UE in the target time unit; and performing the uplink transmission on the time-domain resource and the frequency-domain resource scheduled in the target time unit in accordance with the scheduling information. detecting an Uplink, UL, grant on a target time-domain resource and a target frequency-domain resource in a first time unit, the UL grant being to schedule one or more User Equipments, UEs, to perform uplink transmission in a target time unit, the first time unit and the target time unit each having a predefined length of B2 symbols, and the predefined length is less than a length of a subframe, where B2 is an integer greater than or equal to 1; acquiring scheduling information for the UE in the target time unit from the UL grant, wherein the scheduling information indicates sizes and positions of a time-domain resource and a frequency-domain resource for the uplink transmission for the UE in the target time unit; and performing the uplink transmission on the time-domain resource and the frequency-domain resource scheduled in the target time unit in accordance with the scheduling information.
A method of converting an audio signal in an intermediate signal format to a set of speaker feeds suitable for playback by an array of speakers, wherein the audio signal in the intermediate signal format is obtainable from an input audio signal by means of a spatial panning function, the method comprising: determining a discrete panning function for the array of speakers; determining a target panning function based on the discrete panning function, wherein determining the target panning function involves smoothing the discrete panning function; and determining a rendering operation for converting the audio signal in the intermediate signal format to the set of speaker feeds, based on the target panning function and the spatial panning function, wherein the discrete panningfunction defines, for each of a plurality of directions of arrival, a discrete panning gain for each speaker of the array of speakers, wherein the discrete panning function is determined by associating each direction of arrival with a speaker of the array of speakers that is closest, in terms of a distance function, to that direction of arrival. determining a discrete panning function for the array of speakers; determining a target panning function based on the discrete panning function, wherein determining the target panning function involves smoothing the discrete panning function; and determining a rendering operation for converting the audio signal in the intermediate signal format to the set of speaker feeds, based on the target panning function and the spatial panning function, wherein the discrete panningfunction defines, for each of a plurality of directions of arrival, a discrete panning gain for each speaker of the array of speakers, wherein the discrete panning function is determined by associating each direction of arrival with a speaker of the array of speakers that is closest, in terms of a distance function, to that direction of arrival.
A bipolar electrosurgical colpotomy device comprising: a colpotomy cup (10, 10C) that includes a proximal end, a distal end, a hollow portion at the distal end, a rim (30, 55C) around the hollow portion at the distal end, and a first electrode (31, 76B, 76C) located adjacent to the rim, the rim being configured to contact an internal surface of a patient's cervico-vaginal junction; characterized in further comprising: a tissue containment bag (20, 220) that includes an opening and a second electrode (51, 251) located adjacent to the opening, the tissue containment bag being configured to surround the patient's uterus and the opening being configured to fit over an external surface of the patient's cervico-vaginal junction, wherein application of a voltage potential between the first and second electrodes vaporizes tissue at the patient's cervico-vaginal junction by electrosurgical energy passing through the tissue disposed between the first and second electrodes. a colpotomy cup (10, 10C) that includes a proximal end, a distal end, a hollow portion at the distal end, a rim (30, 55C) around the hollow portion at the distal end, and a first electrode (31, 76B, 76C) located adjacent to the rim, the rim being configured to contact an internal surface of a patient's cervico-vaginal junction; characterized in further comprising: a tissue containment bag (20, 220) that includes an opening and a second electrode (51, 251) located adjacent to the opening, the tissue containment bag being configured to surround the patient's uterus and the opening being configured to fit over an external surface of the patient's cervico-vaginal junction, wherein application of a voltage potential between the first and second electrodes vaporizes tissue at the patient's cervico-vaginal junction by electrosurgical energy passing through the tissue disposed between the first and second electrodes. a tissue containment bag (20, 220) that includes an opening and a second electrode (51, 251) located adjacent to the opening, the tissue containment bag being configured to surround the patient's uterus and the opening being configured to fit over an external surface of the patient's cervico-vaginal junction, wherein application of a voltage potential between the first and second electrodes vaporizes tissue at the patient's cervico-vaginal junction by electrosurgical energy passing through the tissue disposed between the first and second electrodes.
Apparatus for determining a status of a medical device component, wherein the apparatus comprises:- at least one fusible component to indicate whether the medical device component has been used; at least one reference resistor; and at least one further reference resistor, wherein: the combination of the at least one reference resistor and the at least further reference resistor has at least one reference property that is representative of the presence, identity or type of the medical device component; the at least one reference resistor and the at least one further reference resistor are each non-fusible under ordinary operating conditions; the at least one fusible component, the at least one reference resistor and the at least one further reference resistor are arranged on a measurement path between terminals (100, 102); the at least one fusible component and the at least one reference resistor are arranged in parallel on the measurement path; the at least one fusible component and the at least one further reference resistor are arranged in series on the measurement path; the at least one fusible component, the at least one reference resistor and the at least one further reference resistor are arranged so that in operation it can be determined whether the at least one fusible component has fused from the value of a resistance measurement at the terminals (100, 102); and said at least one reference property representative of the presence, identity or type of the medical device component can be determined from the value of the resistance measurement. the combination of the at least one reference resistor and the at least further reference resistor has at least one reference property that is representative of the presence, identity or type of the medical device component; the at least one reference resistor and the at least one further reference resistor are each non-fusible under ordinary operating conditions; the at least one fusible component, the at least one reference resistor and the at least one further reference resistor are arranged on a measurement path between terminals (100, 102); the at least one fusible component and the at least one reference resistor are arranged in parallel on the measurement path; the at least one fusible component and the at least one further reference resistor are arranged in series on the measurement path; the at least one fusible component, the at least one reference resistor and the at least one further reference resistor are arranged so that in operation it can be determined whether the at least one fusible component has fused from the value of a resistance measurement at the terminals (100, 102); and said at least one reference property representative of the presence, identity or type of the medical device component can be determined from the value of the resistance measurement.
An electronic driving circuit for a microfluidic device having a number of electrodes (4,6), comprising a number of synchronized driving stages configured to generate a respective driving signal (V 1, V 2, V 3) for each electrode or group of electrodes of the number of electrodes (4, 6); the driving signals (V 1, V 2, V 3) having a desired amplitude, frequency and phase-shift, wherein each driving stage includes a switching-mode amplifier stage configured to receive a clock signal and a target signal (Vt) and to generate, at an output (Out) thereof, an output signal (V out) defining the respective driving signal, the amplifier stage comprising: a switching module, coupled to a first internal node (N 1) and controlled by the clock signal for selectively bringing said first internal node (N 1) to a control signal (V c); and a filter module (25,26), coupled between the first internal node (N 1) and the output (Out) and configured to provide the output signal (V out); characterized in that the amplifier stage further comprises: a feedback module, coupled to a feedback input (IN fb) of said driving stage, designed to receive a feedback signal (V fb) indicative of the value of the respective driving signal, and configured to: generate, as a function of the comparison between said feedback signal (V fb) and said target signal (V t), the control signal (V c) for said switching module; and to feed-back the control signal (V c) towards the switching module, to modulate the clock signal and define the output signal (V out). a switching module, coupled to a first internal node (N 1) and controlled by the clock signal for selectively bringing said first internal node (N 1) to a control signal (V c); and a filter module (25,26), coupled between the first internal node (N 1) and the output (Out) and configured to provide the output signal (V out); characterized in that the amplifier stage further comprises: a feedback module, coupled to a feedback input (IN fb) of said driving stage, designed to receive a feedback signal (V fb) indicative of the value of the respective driving signal, and configured to: generate, as a function of the comparison between said feedback signal (V fb) and said target signal (V t), the control signal (V c) for said switching module; and to feed-back the control signal (V c) towards the switching module, to modulate the clock signal and define the output signal (V out).
A process for the epoxidation of an olefin, comprising the steps: a) providing a dry, shaped titanium silicalite catalyst; b) contacting said catalyst with a first conditioning liquid comprising more than 60 % by weight water and less than 40 % by weight methanol to provide a conditioned catalyst; c) optionally contacting said catalyst subsequent to step b) with at least one further conditioning liquid having a methanol content higher than the methanol content of said first conditioning liquid; and d) passing a mixture comprising olefin, hydrogen peroxide, water and methanol through a catalyst fixed bed comprising said conditioned catalyst, wherein the weight ratio of water to methanol is less than 1; wherein at least one of said conditioning liquids comprises water and from 25 to 45 % by weight methanol with the combined amount of water and methanol being at least 95 % by weight. a) providing a dry, shaped titanium silicalite catalyst; b) contacting said catalyst with a first conditioning liquid comprising more than 60 % by weight water and less than 40 % by weight methanol to provide a conditioned catalyst; c) optionally contacting said catalyst subsequent to step b) with at least one further conditioning liquid having a methanol content higher than the methanol content of said first conditioning liquid; and d) passing a mixture comprising olefin, hydrogen peroxide, water and methanol through a catalyst fixed bed comprising said conditioned catalyst, wherein the weight ratio of water to methanol is less than 1;
A radio frequency identification (RFID) tag, said RFID tag comprising: - a first communication module adapted and configured to receive signals from a RFID reader, said first communication module including means for extracting energy from the received signals providing a supply voltage Vdd to the RFID tag; - at least one energy storage module in connection with and supplied by the first communication module adapted and configured to store said extracted energy from the received signals of the RFID reader; - a second communication module adapted and configured to communicate with at least one external device; and - a power output in connection with and supplied by the second communication module adapted and configured to provide a power-supply voltage to said at least one external device using said stored energy in said at least one energy storage module, characterized in that: - the RFID tag further comprises a control module in connection with the second communication module, said control module being adapted and configured to perform a tracking of said power-supply voltage provided by said power output to the at least one external device; - the control module being further in connection with the first communication module; and - the first communication module being further adapted and configured to transmit to the RFID reader a quality indicator of an energy status of the RFID tag based on the result of said tracking of said power-supply voltage. - a first communication module adapted and configured to receive signals from a RFID reader, said first communication module including means for extracting energy from the received signals providing a supply voltage Vdd to the RFID tag; - at least one energy storage module in connection with and supplied by the first communication module adapted and configured to store said extracted energy from the received signals of the RFID reader; - a second communication module adapted and configured to communicate with at least one external device; and - a power output in connection with and supplied by the second communication module adapted and configured to provide a power-supply voltage to said at least one external device using said stored energy in said at least one energy storage module, - the RFID tag further comprises a control module in connection with the second communication module, said control module being adapted and configured to perform a tracking of said power-supply voltage provided by said power output to the at least one external device; - the control module being further in connection with the first communication module; and - the first communication module being further adapted and configured to transmit to the RFID reader a quality indicator of an energy status of the RFID tag based on the result of said tracking of said power-supply voltage.
An apparatus for protecting the heart from an implanted inlet element of a blood pump comprising: a flange member having a first radially constricted configuration and a second radially expanded configuration, the flange member being biased in its second radially expanded configuration, the flange member defining an opening there through sized to receiving the inlet element of the blood pump; and a retaining element extending from the flange member, the retaining element being flexible and sized to be disposed about at least a portion of the inlet element, the retaining element defines a tubular body having a proximal end and a distal end, the tubular body defines an annular pocket distal to the distal end of the tubular body, and the flange member includes a flexible washer disposed within the annular pocket. a flange member having a first radially constricted configuration and a second radially expanded configuration, the flange member being biased in its second radially expanded configuration, the flange member defining an opening there through sized to receiving the inlet element of the blood pump; and a retaining element extending from the flange member, the retaining element being flexible and sized to be disposed about at least a portion of the inlet element, the retaining element defines a tubular body having a proximal end and a distal end, the tubular body defines an annular pocket distal to the distal end of the tubular body, and the flange member includes a flexible washer disposed within the annular pocket.
A parking assistance method for a parking assistance device that searches for an empty parking space that meets a specified condition around a mobile object and displays a first assistance image (24, 25) at a position of the empty parking space in a surrounding image that is a view of an area including the mobile object from above, the first assistance image (24, 25) indicating the empty parking space, the parking assistance method comprising: detecting a turning angle of the mobile object; and characterized in that in a case where the turning angle of the mobile object has become larger than or equal to a specified value, determining the mobile object is turning, and in a case where it is determined that the mobile object is turning, prohibiting the first assistance image (24, 25) from being displayed. detecting a turning angle of the mobile object; and characterized in that in a case where the turning angle of the mobile object has become larger than or equal to a specified value, determining the mobile object is turning, and in a case where it is determined that the mobile object is turning, prohibiting the first assistance image (24, 25) from being displayed.
A surgical device comprising: a tube comprising a wall having a plurality of slits oriented generally transverse to a longitudinal axis of the tube, wherein each slit is defined by opposing surfaces; and a force transmission element coupled to the tube; wherein in a flexible state of the tube, at least some of the opposing surfaces defining respective slits are separated from one another; wherein in a stiffened state of the tube, a force exerted on the force transmission element causes the opposing surfaces of each slit to contact one another, wherein the slits are configured to straighten and compress the tube along a longitudinal axis of the tube in the stiffened state; and wherein a first portion of the tube includes a right hand helical slit pattern characterized in that a second portion of the tube includes a left hand helical slit pattern wherein the right and left hand helical slit patterns are configured to produce a known compression twist in each of the first and second portions as the tube is placed in the stiffened state. a tube comprising a wall having a plurality of slits oriented generally transverse to a longitudinal axis of the tube, wherein each slit is defined by opposing surfaces; and a force transmission element coupled to the tube; wherein in a flexible state of the tube, at least some of the opposing surfaces defining respective slits are separated from one another; wherein in a stiffened state of the tube, a force exerted on the force transmission element causes the opposing surfaces of each slit to contact one another, wherein the slits are configured to straighten and compress the tube along a longitudinal axis of the tube in the stiffened state; and wherein a first portion of the tube includes a right hand helical slit pattern characterized in that a second portion of the tube includes a left hand helical slit pattern wherein the right and left hand helical slit patterns are configured to produce a known compression twist in each of the first and second portions as the tube is placed in the stiffened state.
An anti-tumor agent for use in the treatment of pancreatic cancer comprising: paclitaxel or a salt thereof; and 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine or a salt thereof. paclitaxel or a salt thereof; and 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine or a salt thereof.