mhurhangee/ep-ind-claims huggingface dataset:
A method for classifying a tissue sample obtained from a mammary tumour, said method comprising - determining a stiffness value for each of a plurality of points on said tissue sample using an atomic force microscope, resulting in a stiffness distribution, and - assigning said sample to one of the following breast cancer molecular subtypes based on said stiffness distribution: • luminal A subtype non-metastasized breast cancer, • luminal B subtype non-metastasized breast cancer, • luminal A subtype metastasized breast cancer, • luminal B subtype metastasized breast cancer, • luminal B like Her2+ subtype metastasized breast cancer, • basal subtype non-metastasized breast cancer, and • basal subtype metastasized breast cancer. - determining a stiffness value for each of a plurality of points on said tissue sample using an atomic force microscope, resulting in a stiffness distribution, and - assigning said sample to one of the following breast cancer molecular subtypes based on said stiffness distribution: • luminal A subtype non-metastasized breast cancer, • luminal B subtype non-metastasized breast cancer, • luminal A subtype metastasized breast cancer, • luminal B subtype metastasized breast cancer, • luminal B like Her2+ subtype metastasized breast cancer, • basal subtype non-metastasized breast cancer, and • basal subtype metastasized breast cancer. • luminal A subtype non-metastasized breast cancer, • luminal B subtype non-metastasized breast cancer, • luminal A subtype metastasized breast cancer, • luminal B subtype metastasized breast cancer, • luminal B like Her2+ subtype metastasized breast cancer, • basal subtype non-metastasized breast cancer, and • basal subtype metastasized breast cancer.
A prosthetic device for implantation into a bone, the device comprising: a modular neck component comprising a proximal end, a distal end, and an outer tapered portion, extending below the distal end of the modular neck component; and a stem component having a recess formed in a proximal portion thereof, said recess having a first portion defined by a first tapered sidewall, and a second portion defined by a second tapered sidewall; wherein the proximal portion of said stem component flares outwardly in a distal-to-proximal direction into an outward flare to thereby form a flared surface portion that forms a flare angle relative to a longitudinal axis of the stem component within a range of about fifteen to about forty-five degrees characterized in that the modular neck component comprises an inner tapered portion extending distally below the outer tapered portion, and in that the outer tapered portion, of the modular neck component comprises a plurality of first splines, defined within a perimeter of the outer tapered portion, and wherein the first sidewall of the first portion of the recess comprises a plurality of corresponding second splines for matingly engaging the plurality of first splines of said modular neck component to thereby position the modular neck component in multiple, predetermined orientations within said recess of the proximal portion of the stem component. a modular neck component comprising a proximal end, a distal end, and an outer tapered portion, extending below the distal end of the modular neck component; and a stem component having a recess formed in a proximal portion thereof, said recess having a first portion defined by a first tapered sidewall, and a second portion defined by a second tapered sidewall; wherein the proximal portion of said stem component flares outwardly in a distal-to-proximal direction into an outward flare to thereby form a flared surface portion that forms a flare angle relative to a longitudinal axis of the stem component within a range of about fifteen to about forty-five degrees characterized in that the modular neck component comprises an inner tapered portion extending distally below the outer tapered portion, and in that the outer tapered portion, of the modular neck component comprises a plurality of first splines, defined within a perimeter of the outer tapered portion, and wherein the first sidewall of the first portion of the recess comprises a plurality of corresponding second splines for matingly engaging the plurality of first splines of said modular neck component to thereby position the modular neck component in multiple, predetermined orientations within said recess of the proximal portion of the stem component.
A method of defining an access policy with respect to a data object, the method involving a data structure that comprises: (i) at least one interest-based access list specifying a metadata and a group of persons that are potentially interested in accessing a data object that can be characterized by this metadata; and (ii) at least one privacy-based access list specifying a metadata and a group of persons that are authorized to access a data object that can be characterized by this metadata; the method comprising: - an analysis step in which the data object is analyzed so as to obtain at least one metadata that characterizes the data object; - a list identification step in which a search is carried out in the data structure so as to identify at least one interest-based access list and at least one privacy-based access list specifying metadata that matches with a metadata that characterizes the data object; - an access list composition step in which a recommended access list for the data object is composed, the recommended access list specifying those persons who occur in at least one interest-based access list that has been identified, as well as in at least one privacy-based access list that has been identified. (i) at least one interest-based access list specifying a metadata and a group of persons that are potentially interested in accessing a data object that can be characterized by this metadata; and (ii) at least one privacy-based access list specifying a metadata and a group of persons that are authorized to access a data object that can be characterized by this metadata; - an analysis step in which the data object is analyzed so as to obtain at least one metadata that characterizes the data object; - a list identification step in which a search is carried out in the data structure so as to identify at least one interest-based access list and at least one privacy-based access list specifying metadata that matches with a metadata that characterizes the data object; - an access list composition step in which a recommended access list for the data object is composed, the recommended access list specifying those persons who occur in at least one interest-based access list that has been identified, as well as in at least one privacy-based access list that has been identified.
A method of providing availability data, comprising: receiving, at a presence server, availability data associated with a data file stored on a first client device, the data file having an associated availability indicator configured to be displayed on at least one second client device; storing the received availability data at the presence server; and distributing the stored availability data to the at least one second client device, the availability indicator associated with the data file being configured to indicate a status of the data file on a display at the second client device. receiving, at a presence server, availability data associated with a data file stored on a first client device, the data file having an associated availability indicator configured to be displayed on at least one second client device; storing the received availability data at the presence server; and distributing the stored availability data to the at least one second client device, the availability indicator associated with the data file being configured to indicate a status of the data file on a display at the second client device.
A method for diagnosing a disease in a patient comprised of the following: separating serum or plasma from blood collected from a patient; partitioning said serum or plasma in at least one aqueous two-phase partitioning system, wherein said two-phase partitioning system is adapted to differentially partition albumin when said disease is present or absent in said patient; assaying aqueous phases of said at least one two phase partitioning system for human serum albumin using a specific assay for said albumin; calculating partition coefficient K of albumin for each aqueous phases; and, determining presence of said disease in said patient by comparing numerical values of calculated partition coefficients with reference values previously determined for albumin in serum or plasma taken from individuals with and without said disease, wherein said disease is breast or colon cancer. separating serum or plasma from blood collected from a patient; partitioning said serum or plasma in at least one aqueous two-phase partitioning system, wherein said two-phase partitioning system is adapted to differentially partition albumin when said disease is present or absent in said patient; assaying aqueous phases of said at least one two phase partitioning system for human serum albumin using a specific assay for said albumin; calculating partition coefficient K of albumin for each aqueous phases; and, determining presence of said disease in said patient by comparing numerical values of calculated partition coefficients with reference values previously determined for albumin in serum or plasma taken from individuals with and without said disease, wherein said disease is breast or colon cancer.
An intra-ocular lens system, comprising: an intra-ocular lens (252, 352, 452, 652); and an electro-active lens element (218, 326, 430, 618) in optical communication therewith, characterised in that when said electro-active lens element provides a non-zero optical power, said intra-ocular lens provides the majority of optical power in the system. an intra-ocular lens (252, 352, 452, 652); and an electro-active lens element (218, 326, 430, 618) in optical communication therewith, characterised in that when said electro-active lens element provides a non-zero optical power, said intra-ocular lens provides the majority of optical power in the system.
A method for characterising and/or prognosing prostate cancer in a subject comprising: measuring the level of at least Complement C3 or at least one peptide thereof in a sample from the subject wherein the level of Complement C3 or the at least one peptide thereof is used to provide a characterisation of and/or a prognosis for the prostate cancer, wherein the characterisation of and/or prognosis for the prostate cancer comprises determining the presence or absence of extra-capsular extension. measuring the level of at least Complement C3 or at least one peptide thereof in a sample from the subject wherein the level of Complement C3 or the at least one peptide thereof is used to provide a characterisation of and/or a prognosis for the prostate cancer, wherein the characterisation of and/or prognosis for the prostate cancer comprises determining the presence or absence of extra-capsular extension.
A hydraulic system comprising a pressure source, at least a hydraulic consumer (12, 13), and a pressure booster arranged between the pressure source and the hydraulic consumer (12, 13), wherein inactivating means are provided inactivating or activating said pressure booster, said pressure booster and said inactivating means being part of a booster module, wherein said booster module is part of a valve block, said valve block comprising said booster module and at least one valve module (9, 10) controlling said hydraulic consumer (12, 13), characterized in that the booster module is positioned between two valve modules (9, 10), a hydraulic consumer (12, 13) being connected to each of the two valve modules (9, 10), respectively.
Method for picking bristle bundles from a supply of loose bristle filaments, wherein a bundle picker having a picking notch is moved in a picking movement past the supply of loose bristle bundles, in the process a bristle bundle being separated from the supply and making its way into the picking notch, characterized in that, when the picking movement is carried out, the picking notch changes its direction of movement in a picking region on the supply at least twice, preferably at least thrice.
A method for purifying ropinirole hydrochloride, 4-(2-di-n-propylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride, represented by a structural formula, wherein -R represents C 1 -C 6 alkyl or C 6 -C 10 aromatic group; and -L represents halogen -X, or acyloxy comprising the following steps: mixing ropinirole hydrochloride containing an impurity A, monopropyl ropinirole, represented by a structural formula with water and an organic solvent, stirring and dissolving to obtain a clear solution at room temperature, adding an alkali, stirring, standing for demixing, and removing an aqueous layer, wherein the organic solvent is an aprotic solvent; and the alkali is a hydroxide, carbonate or bicarbonate of an alkali metal or alkaline earth metal, or an amine mono- or polysubstituted by C 1 -C 6 alkyl; drying an organic layer obtained over anhydrous magnesium sulfate and filtering; or subjecting the organic layer obtained directly to a next step without addition of anhydrous magnesium sulfate; adding acid halide or acid anhydride of a structural formula to the organic layer, stirring and concentrating; and after concentrating to dryness to obtain an oily substance, adding an organic solvent to the obtained oily substance, adding a concentrated hydrochloric acid, and stirring to obtain ropinirole hydrochloride, wherein the organic solvent is an alcohol. wherein -R represents C 1 -C 6 alkyl or C 6 -C 10 aromatic group; and -L represents halogen -X, or acyloxy mixing ropinirole hydrochloride containing an impurity A, monopropyl ropinirole, represented by a structural formula with water and an organic solvent, stirring and dissolving to obtain a clear solution at room temperature, adding an alkali, stirring, standing for demixing, and removing an aqueous layer, wherein the organic solvent is an aprotic solvent; and the alkali is a hydroxide, carbonate or bicarbonate of an alkali metal or alkaline earth metal, or an amine mono- or polysubstituted by C 1 -C 6 alkyl; drying an organic layer obtained over anhydrous magnesium sulfate and filtering; or subjecting the organic layer obtained directly to a next step without addition of anhydrous magnesium sulfate; adding acid halide or acid anhydride of a structural formula to the organic layer, stirring and concentrating; and after concentrating to dryness to obtain an oily substance, adding an organic solvent to the obtained oily substance, adding a concentrated hydrochloric acid, and stirring to obtain ropinirole hydrochloride, wherein the organic solvent is an alcohol.
A production method of a tar-containing gas reforming catalyst, comprising: adding a precipitant to a solution containing a nickel compound and a magnesium compound to co-precipitate nickel and magnesium and produce a precipitate, drying and firing said precipitate to produce oxides of nickel and magnesium, adding and mixing (a) an alumina powder and water or (b) an alumina sol to said oxides to produce a mixture, and at least drying and firing said mixture to produce the catalyst. adding a precipitant to a solution containing a nickel compound and a magnesium compound to co-precipitate nickel and magnesium and produce a precipitate, drying and firing said precipitate to produce oxides of nickel and magnesium, adding and mixing (a) an alumina powder and water or (b) an alumina sol to said oxides to produce a mixture, and at least drying and firing said mixture to produce the catalyst.
A percutaneous pump system, the system comprising: a cannula having a proximal inlet, a proximal section, a first distal section, and a distal outlet; a percutaneous pump configured to couple to the proximal inlet; and a guidewire on which the cannula can be backloaded, wherein the cannula has a transition zone between the proximal section and the first distal section and the proximal section has a first flexural modulus and the first distal section has a second flexural modulus which is smaller than the first flexural modulus, characterized in that the first flexural modulus is configured to increase a buckling force of the cannula and the second flexural modulus is configured to match a flexural modulus of the guidewire. a cannula having a proximal inlet, a proximal section, a first distal section, and a distal outlet; a percutaneous pump configured to couple to the proximal inlet; and a guidewire on which the cannula can be backloaded, wherein the cannula has a transition zone between the proximal section and the first distal section and the proximal section has a first flexural modulus and the first distal section has a second flexural modulus which is smaller than the first flexural modulus, characterized in that the first flexural modulus is configured to increase a buckling force of the cannula and the second flexural modulus is configured to match a flexural modulus of the guidewire.
A pharmaceutically acceptable salt of ( R, R)- trans -(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)(3-fluoro-4-hydroxypyrrolidin-1-yl)methanone, wherein the pharmaceutically acceptable salt is a mesylate salt, having the structure of Compound 2: wherein: Compound 2 (form 1) is crystalline and has the following property: an X-ray powder diffraction (XRPD) pattern with characteristic peaks at 13.6° 2-Theta, 16.9° 2-Theta, 19.4° 2-Theta, 20.1° 2-Theta, 20.3° 2-Theta, 20.6° 2-Theta, 23.1° 2-Theta, and 23.6° 2-Theta.
A compound represented by Formula 1: wherein: X 1 is O or S, X 2, X 3 and X 4 are each independently N or CH, L 1 and L 2 are each independently a single bond, R 1 and R 2 are each independently R 3 is each independently a C 6-60 aryl substituted with one or two cyano, and n is an integer of 1 or 2. X 1 is O or S, X 2, X 3 and X 4 are each independently N or CH, L 1 and L 2 are each independently a single bond, R 1 and R 2 are each independently R 3 is each independently a C 6-60 aryl substituted with one or two cyano, and n is an integer of 1 or 2.
A space plasma generator for producing a large area plasma region in the ionosphere, comprising a highly ionizable plasma forming material connectable to a source of high amplitude current and configured to receive a high amplitude current pulse and to be converted into a plasma; wherein the space plasma generator comprises a plasma chamber comprising a tube of insulating material or dielectric material, said tube being either provided with openings in the form of slits or being completely closed, and having a coating, or layer, of the highly ionizable plasma forming material on an interior surface of said tube, such that, in use, the plasma formed by the highly ionizable plasma forming material occupies a large volume in the ionosphere.
A hot-rolled steel sheet having high composite corrosion resistance to sulfuric acid and hydrochloric acid, the hot-rolled steel sheet comprising, by wt%, carbon: 0.05% to 0.1%, manganese (Mn): 0.5% to 1.5%, phosphorus: 0.02% or less, sulfur: 0.02% or less, aluminum (Al): 0.01% to 0.1%, copper (Cu): 0.2% to 0.6%, antimony (Sb): 0.05% to 0.1%, and a balance of iron (Fe) and inevitable impurities, wherein copper (Cu) and antimony (Sb) are concentrated in a region from a surface to a 500-nm position in a thickness direction of the hot-rolled steel sheet, and the hot-rolled steel sheet has a corrosion loss of 2.0 mg/cm 2 /hr in 6 hours or less in a solution of 16.9 volume% sulfuric acid and 0.35 volume% hydrochloric acid having a temperature of 60°C.
Process for the production of a hydrocarbon fluid comprising the step of catalytically hydrogenating a hydrocarbon cut in presence of both a dearomatization catalyst and a dewaxing catalyst in a single slurry reactor, wherein the dearomatization catalyst amount is comprised between 0.1 and 6 wt%, based on the weight of the hydrocarbon cut and/or the dewaxing catalyst amount is comprised between 0.1 and 6 wt% based on the weight of the hydrocarbon cut, wherein the dearomatization catalyst is selected from the group consisting of metals of the Group VIII and/or Group VIB metal and wherein the dewaxing catalyst is selected from the group consisting of silicalite having preferably a silica/alumina ratio greater than 130, alumina, zeolites, MFI zeolites, silicoaluminophosphates, aluminosilicate, comprising 0 to 10% by weight of at least one metal from group VIII and optionally 0 to 20% by weight of a group VI metal, wherein the hydrocarbon cut has a sulphur content below 15 ppm, wherein the hydrocarbon cut is a gasoil having a final boiling point above 300°C.
A method of enabling channel estimation by a base station, comprising: receiving a primary pilot channel signal which has been transmitted on a dominant eigenmode and a secondary pilot channel signal; estimating two or more composite channel values from the received primary and secondary pilot channel signals; estimating two or more physical channel values from the estimated two or more composite channel values; filtering the estimated two or more physical channel values to increase the observed signal-to-noise ratio; and deriving a channel estimate for the dominant eigenmode of the composite channel from the two or more filtered physical channel values and a beamforming weight vector. receiving a primary pilot channel signal which has been transmitted on a dominant eigenmode and a secondary pilot channel signal; estimating two or more composite channel values from the received primary and secondary pilot channel signals; estimating two or more physical channel values from the estimated two or more composite channel values; filtering the estimated two or more physical channel values to increase the observed signal-to-noise ratio; and deriving a channel estimate for the dominant eigenmode of the composite channel from the two or more filtered physical channel values and a beamforming weight vector.