A compound of Formula I-A: wherein R 1 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, 2-hydroxyprop-2-yl, butyl, sec-butyl, tert-butyl, isobutyl, pentyl, dimethylaminomethyl and hexyl; R 2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropylmethyl, and methoxyethyl; R 3 is a 5- to 12- membered monocyclic or bridged heterocycloalkyl ring, wherein the R 3 group is substituted with from 0 to 3 R R3 substituents selected from the group consisting of -C OR g,-C NR g R h, -NR g R h, -OR g, -SR g, -S 2 R i, -S R i, -R i, halogen, F, Cl, Br, I, -NO 2, -CN and -N 3, wherein R g and R h are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl and C 3-6 cycloalkyl, wherein optionally R g and R h, together with the nitrogen atom to which each is attached, are combined to form a 3- to 6-membered heterocyclic ring comprising 1 to 2 heteroatoms selected from N, O and S, and R 1 is selected from C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl; and when R 3 is a monocyclic heterocycloalkyl ring then any two R R3 groups attached to the same atom of R 3 is optionally combined to form at 3- to 7-membered carbocyclic or 3-to 7- membered heterocyclic ring comprising 1 to 2 atoms selected from N, O and S as ring vertices; and D is -NR 4 C NR 5 R 6 or -NR 5 R 6, wherein R 4 is hydrogen, R 5 and R 6 are each independently an optionally substituted group selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-10 aryl, and C 1-9 heteroaryl, and R 5 and R 6, when attached to the same nitrogen atom, are optionally combined to form an a 5- to 7- heterocyclic ring or a 5- to 9- membered heteroaryl ring comprising 1 to 3 heteroatoms selected from N, O and S as ring vertices and is substituted with from 0 to 3 R D substituents, wherein R D is independently selected from the group consisting of halogen, F, Cl, Br, I, -NO 2, -CN, -NR j R k, -OR j, -SR j, -C OR j, -C NR l R k, -NR j C R k, -NR j C OR m, -X 3 -NR j R k, -X 3 -OR j, -X 3 -SR j, -X 3 -C OR j, -X 3 -C NR j R k, -X 3 -NR j C R k, -X 3 -NR j C OR k, -X 3 -CN, -X 3 -NO 2, -S R m, -S 2 R m, =O, and -R m; wherein R j and R k is selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 heteroalkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 6-10 aryl, C 1-9 heteroaryl; and R m, at each occurrence, is independently selected from C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 6-10 aryl and C 1-9 heteroaryl; X 3 is selected from the group consisting of C 1-4 alkylene, C 2-4 alkenylene and C 2-4 alkynylene. wherein R 1 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, 2-hydroxyprop-2-yl, butyl, sec-butyl, tert-butyl, isobutyl, pentyl, dimethylaminomethyl and hexyl; R 2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropylmethyl, and methoxyethyl; R 3 is a 5- to 12- membered monocyclic or bridged heterocycloalkyl ring, wherein the R 3 group is substituted with from 0 to 3 R R3 substituents selected from the group consisting of -C OR g,-C NR g R h, -NR g R h, -OR g, -SR g, -S 2 R i, -S R i, -R i, halogen, F, Cl, Br, I, -NO 2, -CN and -N 3, wherein R g and R h are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl and C 3-6 cycloalkyl, wherein optionally R g and R h, together with the nitrogen atom to which each is attached, are combined to form a 3- to 6-membered heterocyclic ring comprising 1 to 2 heteroatoms selected from N, O and S, and R 1 is selected from C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl; and when R 3 is a monocyclic heterocycloalkyl ring then any two R R3 groups attached to the same atom of R 3 is optionally combined to form at 3- to 7-membered carbocyclic or 3-to 7- membered heterocyclic ring comprising 1 to 2 atoms selected from N, O and S as ring vertices; and D is -NR 4 C NR 5 R 6 or -NR 5 R 6, wherein R 4 is hydrogen, R 5 and R 6 are each independently an optionally substituted group selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-10 aryl, and C 1-9 heteroaryl, and R 5 and R 6, when attached to the same nitrogen atom, are optionally combined to form an a 5- to 7- heterocyclic ring or a 5- to 9- membered heteroaryl ring comprising 1 to 3 heteroatoms selected from N, O and S as ring vertices and is substituted with from 0 to 3 R D substituents, wherein R D is independently selected from the group consisting of halogen, F, Cl, Br, I, -NO 2, -CN, -NR j R k, -OR j, -SR j, -C OR j, -C NR l R k, -NR j C R k, -NR j C OR m, -X 3 -NR j R k, -X 3 -OR j, -X 3 -SR j, -X 3 -C OR j, -X 3 -C NR j R k, -X 3 -NR j C R k, -X 3 -NR j C OR k, -X 3 -CN, -X 3 -NO 2, -S R m, -S 2 R m, =O, and -R m; wherein R j and R k is selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 heteroalkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 6-10 aryl, C 1-9 heteroaryl; and R m, at each occurrence, is independently selected from C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 6-10 aryl and C 1-9 heteroaryl; X 3 is selected from the group consisting of C 1-4 alkylene, C 2-4 alkenylene and C 2-4 alkynylene.