An air-conditioning apparatus (100, 100A) comprising: a refrigerant circuit in which a compressor, a first refrigerant flow switching device, a heat source side heat exchanger, a plurality of expansion devices, refrigerant passages of a plurality of heat exchangers related to heat medium, and a plurality of second refrigerant flow switching devices are connected by refrigerant pipes to circulate a heat source side refrigerant; and a heat medium circuit in which a pump, a use side heat exchanger, heat medium side passages of the plurality of heat exchangers related to heat medium, a heat medium flow control device disposed on an inlet side or an outlet side of the use side heat exchanger, and heat medium flow switching devices (22, 23) arranged on the inlet side and the outlet side of the use side heat exchanger are connected by heat medium pipes to circulate a heat medium, wherein the plurality of heat exchangers related to heat medium exchange heat between the heat source side refrigerant and the heat medium, wherein the refrigerant circuit branches into a plurality of refrigerant passages, characterized in that a part of the refrigerant passages each connect the corresponding expansion device, the corresponding second refrigerant flow switching device, and a plurality of first heat exchangers related to heat medium connected in parallel between the expansion device and the second refrigerant flow switching device, wherein a rest of the refrigerant passages each connect the corresponding expansion device, the corresponding second refrigerant flow switching device, and a plurality of second heat exchangers related to heat medium connected in series between the expansion device and the second refrigerant flow switching device, and wherein the air-conditioning apparatus (100, 100A) is configured such that pressure loss in a refrigerant passage of the second heat exchangers related to heat medium is larger than pressure loss in a refrigerant passage of the first heat exchangers related to heat medium, and the refrigerant passage of the second heat exchangers related to heat medium has a longer passage length in a flow direction than the refrigerant passage of the first heat exchangers related to heat medium. a refrigerant circuit in which a compressor, a first refrigerant flow switching device, a heat source side heat exchanger, a plurality of expansion devices, refrigerant passages of a plurality of heat exchangers related to heat medium, and a plurality of second refrigerant flow switching devices are connected by refrigerant pipes to circulate a heat source side refrigerant; and a heat medium circuit in which a pump, a use side heat exchanger, heat medium side passages of the plurality of heat exchangers related to heat medium, a heat medium flow control device disposed on an inlet side or an outlet side of the use side heat exchanger, and heat medium flow switching devices (22, 23) arranged on the inlet side and the outlet side of the use side heat exchanger are connected by heat medium pipes to circulate a heat medium, wherein the plurality of heat exchangers related to heat medium exchange heat between the heat source side refrigerant and the heat medium, wherein the refrigerant circuit branches into a plurality of refrigerant passages, characterized in that a part of the refrigerant passages each connect the corresponding expansion device, the corresponding second refrigerant flow switching device, and a plurality of first heat exchangers related to heat medium connected in parallel between the expansion device and the second refrigerant flow switching device, wherein a rest of the refrigerant passages each connect the corresponding expansion device, the corresponding second refrigerant flow switching device, and a plurality of second heat exchangers related to heat medium connected in series between the expansion device and the second refrigerant flow switching device, and wherein the air-conditioning apparatus (100, 100A) is configured such that pressure loss in a refrigerant passage of the second heat exchangers related to heat medium is larger than pressure loss in a refrigerant passage of the first heat exchangers related to heat medium, and the refrigerant passage of the second heat exchangers related to heat medium has a longer passage length in a flow direction than the refrigerant passage of the first heat exchangers related to heat medium.