Active breathing system for an aseptic combination arranged to be worn by a user, comprising: - an aeration device to make possible orientation of air surrounding a cleanroom external to said aseptic combination in an inner portion of said aseptic combination, said aeration device being arranged to be located inside said aseptic combination and comprises ∘ a first longitudinal hollow body arranged to receive a fan which is arranged to be connected to an energy source, ∘ a surrounding air suctioning tube in fluidic communication with said longitudinal hollow body, ∘ a surrounding air outlet likewise in fluidic communication with said longitudinal hollow body and arranged to direct the surrounding air upwards, said active breathing system being characterised in that it also comprises - an air inlet arranged to be situated on an aseptic combination and arranged to make possible passage of the surrounding air on the outside of said combination in an inner portion of said combination, said air inlet making it possible to supply said surrounding air suctioning tube of said aeration device, comprising - a first air suctioning interface comprising a main wall arranged to be situated outside said aseptic combination, from which extends a tube, preferably a lateral tube, arranged to extend through the aseptic combination to the inside of same and be reversibly connected to said surrounding air suctioning tube, said main wall having at least one orifice possibly equipped with a filtering membrane, arranged to make possible the passage of surrounding air outside said combination, in said lateral tube towards the inside of said combination, by sequential passage in said surrounding air suctioning tube, in said first longitudinal hollow body and through said surrounding air outlet. - an aeration device to make possible orientation of air surrounding a cleanroom external to said aseptic combination in an inner portion of said aseptic combination, said aeration device being arranged to be located inside said aseptic combination and comprises ∘ a first longitudinal hollow body arranged to receive a fan which is arranged to be connected to an energy source, ∘ a surrounding air suctioning tube in fluidic communication with said longitudinal hollow body, ∘ a surrounding air outlet likewise in fluidic communication with said longitudinal hollow body and arranged to direct the surrounding air upwards, said active breathing system being characterised in that it also comprises ∘ a first longitudinal hollow body arranged to receive a fan which is arranged to be connected to an energy source, ∘ a surrounding air suctioning tube in fluidic communication with said longitudinal hollow body, ∘ a surrounding air outlet likewise in fluidic communication with said longitudinal hollow body and arranged to direct the surrounding air upwards, said active breathing system being characterised in that it also comprises - an air inlet arranged to be situated on an aseptic combination and arranged to make possible passage of the surrounding air on the outside of said combination in an inner portion of said combination, said air inlet making it possible to supply said surrounding air suctioning tube of said aeration device, comprising - a first air suctioning interface comprising a main wall arranged to be situated outside said aseptic combination, from which extends a tube, preferably a lateral tube, arranged to extend through the aseptic combination to the inside of same and be reversibly connected to said surrounding air suctioning tube, said main wall having at least one orifice possibly equipped with a filtering membrane, arranged to make possible the passage of surrounding air outside said combination, in said lateral tube towards the inside of said combination, by sequential passage in said surrounding air suctioning tube, in said first longitudinal hollow body and through said surrounding air outlet.