The compounds of Formula I or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W is Z is H, F, or CH 3; J is CH, or N; R 2 is X is -C alkylR 1, alkenyl, propenyl-NA 1 A 2, -CH=CH-CO 2 R a, -C alkylR 3 R 4a, or -CH 2 -heteroaryl-C alkyl-R 1; wherein: R 1 is -CN, -SO 2 NA 1 A 2, -SO 2 R a, -SCH 2 CH 2 NA 1 A 2, -SOCH 2 CH 2 NA 1 A 2, -SO 2 CH 2 CH 2 NA 1 A 2, -S-C C alkyl, -S-CH 2 -4-methoxy phenyl, -OC alkylNA 1 A 2, -NA 1 A 2, -NHSO 2 CH 3, -NHCOCH 3, -CONH 2, -CONHCH 2 CH 2 CH 2 OH, -CONHCH 2 CH 2 N(C alkyl) 2, -NHCONH 2, -NHCONHCH 2 CH 2 OH, -NHCOCONH 2, -NR a CH 2 CH 2 NA 1 A 2, -CO 2 R a, pyridyl, -OCOCH 3, or -CH 2 OCOCH 3; A 1 is H or -C alkyl; A 2 is -C alkyl, -CH 2 CH 2 OR a, -COR a, -CH 2 CH 2 SC alkyl, -CH 2 CH 2 SOC alkyl, pyridyl, 2-methyl pyridyl, or -CH 2 CH 2 SO 2 C alkyl; alternatively, A 1 and A 2 may be taken together with their attached nitrogen to form a heterocyclic ring selected from the following: wherein: R a is H or C alkyl; R b is H, -C alkyl, alkoxyether, -C C alkyl, -C alkyl-OH, -C alkyl-O-C alkyl, -C alkyl-C O-C alkyl, -C alkylC OH, -C alkylC ONa, or -CH 2 C C alkyl; and R 3 and R 4a are independently-CH 2 OH, -OCH 3, -CH 2 OCH 3,-CO 2 H, -CO 2 C alkyl, -OC C alkyl, or -OH. W is Z is H, F, or CH 3; J is CH, or N; R 2 is X is -C alkylR 1, alkenyl, propenyl-NA 1 A 2, -CH=CH-CO 2 R a, -C alkylR 3 R 4a, or -CH 2 -heteroaryl-C alkyl-R 1; wherein: R 1 is -CN, -SO 2 NA 1 A 2, -SO 2 R a, -SCH 2 CH 2 NA 1 A 2, -SOCH 2 CH 2 NA 1 A 2, -SO 2 CH 2 CH 2 NA 1 A 2, -S-C C alkyl, -S-CH 2 -4-methoxy phenyl, -OC alkylNA 1 A 2, -NA 1 A 2, -NHSO 2 CH 3, -NHCOCH 3, -CONH 2, -CONHCH 2 CH 2 CH 2 OH, -CONHCH 2 CH 2 N(C alkyl) 2, -NHCONH 2, -NHCONHCH 2 CH 2 OH, -NHCOCONH 2, -NR a CH 2 CH 2 NA 1 A 2, -CO 2 R a, pyridyl, -OCOCH 3, or -CH 2 OCOCH 3; A 1 is H or -C alkyl; A 2 is -C alkyl, -CH 2 CH 2 OR a, -COR a, -CH 2 CH 2 SC alkyl, -CH 2 CH 2 SOC alkyl, pyridyl, 2-methyl pyridyl, or -CH 2 CH 2 SO 2 C alkyl; alternatively, A 1 and A 2 may be taken together with their attached nitrogen to form a heterocyclic ring selected from the following: wherein: R a is H or C alkyl; R b is H, -C alkyl, alkoxyether, -C C alkyl, -C alkyl-OH, -C alkyl-O-C alkyl, -C alkyl-C O-C alkyl, -C alkylC OH, -C alkylC ONa, or -CH 2 C C alkyl; and R 1 is -CN, -SO 2 NA 1 A 2, -SO 2 R a, -SCH 2 CH 2 NA 1 A 2, -SOCH 2 CH 2 NA 1 A 2, -SO 2 CH 2 CH 2 NA 1 A 2, -S-C C alkyl, -S-CH 2 -4-methoxy phenyl, -OC alkylNA 1 A 2, -NA 1 A 2, -NHSO 2 CH 3, -NHCOCH 3, -CONH 2, -CONHCH 2 CH 2 CH 2 OH, -CONHCH 2 CH 2 N(C alkyl) 2, -NHCONH 2, -NHCONHCH 2 CH 2 OH, -NHCOCONH 2, -NR a CH 2 CH 2 NA 1 A 2, -CO 2 R a, pyridyl, -OCOCH 3, or -CH 2 OCOCH 3; A 1 is H or -C alkyl; A 2 is -C alkyl, -CH 2 CH 2 OR a, -COR a, -CH 2 CH 2 SC alkyl, -CH 2 CH 2 SOC alkyl, pyridyl, 2-methyl pyridyl, or -CH 2 CH 2 SO 2 C alkyl; alternatively, A 1 and A 2 may be taken together with their attached nitrogen to form a heterocyclic ring selected from the following: wherein: R a is H or C alkyl; R b is H, -C alkyl, alkoxyether, -C C alkyl, -C alkyl-OH, -C alkyl-O-C alkyl, -C alkyl-C O-C alkyl, -C alkylC OH, -C alkylC ONa, or -CH 2 C C alkyl; and R a is H or C alkyl; R b is H, -C alkyl, alkoxyether, -C C alkyl, -C alkyl-OH, -C alkyl-O-C alkyl, -C alkyl-C O-C alkyl, -C alkylC OH, -C alkylC ONa, or -CH 2 C C alkyl; and R 3 and R 4a are independently-CH 2 OH, -OCH 3, -CH 2 OCH 3,-CO 2 H, -CO 2 C alkyl, -OC C alkyl, or -OH.