A compound of formula II, a cis-trans isomer, an enantiomer, a diastereoisomer, a racemate, a solvate, a hydrate, or a pharmaceutical acceptable salt thereof:: wherein: Z is oxadiazolyl, furyl, thienyl or isoxazolyl, the isoxazolyl is unsubstituted or substituted by one or more substituents selected from the group consisting of H, C1-6 alkyl, and hydroxyl C1-6alky; A is phenylene, pyridinylene, or isoxazolylene; A is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, cyano, and C1-6 alkyl; Y is -NY1Y2 or -NH-NY3Y4; Y1 is H or C1-6 alkyl; Y2 is independently selected from the group consisting of C1-6 alkyl; C1-6 alkyl substituted by 1-5 substituents selected from the group consisting of amino, substituted amino, hydroxyl, C1-6 alkoxy, carboxyl, halogen, C1-6 alkyl-S 2-; cycloalkyl, heterocycloalkyl, and heterocycloalkyl substituted by 1-4 substituents selected from the group consisting of acetamido, acetyl, C1-6 alkoxy, and C1-6 alkyl; H; C1-6 alkyl-S 2-; amino; NH-S 2-; C1-6 alkoxy; C5-6 heteroaryl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur; C5-6 heteroaryl substituted by alkyl, wherein the C5-6 heteroaryl contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur; C4-6 cycloalkyl, cyclopropyl, C3-6 cycloalkyl substituted by 1-4 substituents selected from the group consisting of hydroxyl, C1-6 alkyl, C1-6 alkoxy; C4-6 heterocycloalkyl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur, or C4-6 heterocycloalklyl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur and is substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, acetyl, and S 2-; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form a 4-6 membered heterocycloalkyl which contains the nitrogen atom and 0,1 or more heteroatom selected from O and S, and the sulfur atom is S itself or its oxide form; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form a 4-6 membered heterocycloalkyl which contains 1-3 heteroatoms selected from N, O and S, the sulfur atom is S itself or its oxide form, and the heterocycloalkyl is substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, C1-6 alkylS 2-, C1-6 alkoxy, halogenated C1-6 alkyl, NH2C(=O)-, and halogen; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form C5-10 oxaazabicycloalkyl; Y3 and Y4 are independently selected from the group consisting of hydrogen, methyl, SO2-methyl; alternatively, Y3 and Y4 together with the nitrogen atom to which they are attached, form a heterocyclyl, and the heterocyclyl is selected from the group consisting of piperidinyl, morpholinyl, dioxidothiomorpholinyl. Z is oxadiazolyl, furyl, thienyl or isoxazolyl, the isoxazolyl is unsubstituted or substituted by one or more substituents selected from the group consisting of H, C1-6 alkyl, and hydroxyl C1-6alky; A is phenylene, pyridinylene, or isoxazolylene; A is unsubstituted or substituted by 1, 2 or 3 substituents selected from the group consisting of halogen, cyano, and C1-6 alkyl; Y is -NY1Y2 or -NH-NY3Y4; Y1 is H or C1-6 alkyl; Y2 is independently selected from the group consisting of C1-6 alkyl; C1-6 alkyl substituted by 1-5 substituents selected from the group consisting of amino, substituted amino, hydroxyl, C1-6 alkoxy, carboxyl, halogen, C1-6 alkyl-S 2-; cycloalkyl, heterocycloalkyl, and heterocycloalkyl substituted by 1-4 substituents selected from the group consisting of acetamido, acetyl, C1-6 alkoxy, and C1-6 alkyl; H; C1-6 alkyl-S 2-; amino; NH-S 2-; C1-6 alkoxy; C5-6 heteroaryl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur; C5-6 heteroaryl substituted by alkyl, wherein the C5-6 heteroaryl contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur; C4-6 cycloalkyl, cyclopropyl, C3-6 cycloalkyl substituted by 1-4 substituents selected from the group consisting of hydroxyl, C1-6 alkyl, C1-6 alkoxy; C4-6 heterocycloalkyl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur, or C4-6 heterocycloalklyl that contains 1-3 hetero-atoms independently selected from nitrogen, oxygen or sulfur and is substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, acetyl, and S 2-; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form a 4-6 membered heterocycloalkyl which contains the nitrogen atom and 0,1 or more heteroatom selected from O and S, and the sulfur atom is S itself or its oxide form; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form a 4-6 membered heterocycloalkyl which contains 1-3 heteroatoms selected from N, O and S, the sulfur atom is S itself or its oxide form, and the heterocycloalkyl is substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, C1-6 alkylS 2-, C1-6 alkoxy, halogenated C1-6 alkyl, NH2C(=O)-, and halogen; alternatively, Y1 and Y2 together with the nitrogen atom to which they are attached, form C5-10 oxaazabicycloalkyl; Y3 and Y4 are independently selected from the group consisting of hydrogen, methyl, SO2-methyl; alternatively, Y3 and Y4 together with the nitrogen atom to which they are attached, form a heterocyclyl, and the heterocyclyl is selected from the group consisting of piperidinyl, morpholinyl, dioxidothiomorpholinyl.