Method for picking up a panel from the exit station of a machine for working panels made of wood, ceramic, glass, fiberglass, plastic, metal and the like, comprising a working plane for supporting each panel, said panel being loadable and/or unloadable according to a first and a second loading and/or unloading way; at least one working unit comprising at least one working tool for working said panel, at least one locking member for locking said panel during working, at least one protective member, capable of preventing the contact between said at least one working tool and an operator, said method being characterized in that said first loading and/or unloading way is an automatic loading and/or unloading way of said panel is, carried out by means of an automatic picking up device, in particular a robot, in that when said panel is loaded and/or unloaded according to said first loading and/or unloading way, said method comprises the following steps: 1. placing said panel on said working plane in a predetermined position such as to allow its working; 2. locking, by means of said at least one locking member, said panel in a position on said working plane; 3. carrying out, by means of said at least one working tool, a working of said panel; 4. releasing, by means of said at least one locking member, said panel locked in the locking step 2.; and 5. picking up said panel worked in said working step 3.; in that said second loading and/or unloading way is manual loading and/or unloading way carried out by an operator, and in that, when said panel is loaded and/or unloaded according to said second loading and/or unloading way, said method comprises the following sub-steps: 1.1 placing, after said placing step 1., said at least one protective member in a first position, wherein said at least one protective member forms a protective barrier of said working tool; and 3. 1 placing, after said working step 3., said at least one protective member in a second position, wherein said at least one protective member uncovers said working tool. a working plane for supporting each panel, said panel being loadable and/or unloadable according to a first and a second loading and/or unloading way; at least one working unit comprising at least one working tool for working said panel, at least one locking member for locking said panel during working, at least one protective member, capable of preventing the contact between said at least one working tool and an operator, said method being characterized in that said first loading and/or unloading way is an automatic loading and/or unloading way of said panel is, carried out by means of an automatic picking up device, in particular a robot, in that when said panel is loaded and/or unloaded according to said first loading and/or unloading way, said method comprises the following steps: 1. placing said panel on said working plane in a predetermined position such as to allow its working; 2. locking, by means of said at least one locking member, said panel in a position on said working plane; 3. carrying out, by means of said at least one working tool, a working of said panel; 4. releasing, by means of said at least one locking member, said panel locked in the locking step 2.; and 5. picking up said panel worked in said working step 3.; 1. placing said panel on said working plane in a predetermined position such as to allow its working; 2. locking, by means of said at least one locking member, said panel in a position on said working plane; 3. carrying out, by means of said at least one working tool, a working of said panel; 4. releasing, by means of said at least one locking member, said panel locked in the locking step 2.; and 5. picking up said panel worked in said working step 3.; in that said second loading and/or unloading way is manual loading and/or unloading way carried out by an operator, and in that, when said panel is loaded and/or unloaded according to said second loading and/or unloading way, said method comprises the following sub-steps: 1.1 placing, after said placing step 1., said at least one protective member in a first position, wherein said at least one protective member forms a protective barrier of said working tool; and 3. 1 placing, after said working step 3., said at least one protective member in a second position, wherein said at least one protective member uncovers said working tool. 1.1 placing, after said placing step 1., said at least one protective member in a first position, wherein said at least one protective member forms a protective barrier of said working tool; and 3. 1 placing, after said working step 3., said at least one protective member in a second position, wherein said at least one protective member uncovers said working tool.