A method for predicting overall survival and progression free survival of a subject having cancer, said method comprising determining the number of CCR5 clusters in circulating cells in a biological sample from a subject having cancer, wherein the circulating cells comprise cancer associated macrophage-like cells (CAMLs) and wherein the CAMLs have the following characteristics: (a) large atypical polyploid nucleus of about 14-64 μm in size, or multiple nuclei in a single cell; (b) cell size of about 20-300 μm in size; and (c) morphological shape selected from the group consisting of spindle, tadpole, round, oblong, two legs, more than two legs, thin legs, and amorphous; optionally wherein the CAMLs have one or more of the following additional characteristics: (d) CD14 positive phenotype; (e) CD45 expression; (f) EpCAM expression; (g) vimentin expression; (h) PD-L1 expression; (i) CD11C marker expression; (j) CD146 marker expression; (k) CD202b marker expression; (l) CD31 marker expression; and (m) CK8, 18, 19 epithelial phenotype, wherein the source of the biological sample is one or more of peripheral blood, blood, lymph node, bone marrow, cerebral spinal fluid, tissue, and urine, and wherein when at least one CAML cell in said sample has about 10 or more CCR5 clusters: (i) the OS and PFS of the subject is predicted to be shortened, or (ii) the OS and PFS of the subject is predicted to be shorter than a subject having the same type of cancer where none of the cells in a corresponding biological sample has about 10 or more CCR5 clusters. wherein the circulating cells comprise cancer associated macrophage-like cells (CAMLs) and wherein the CAMLs have the following characteristics: (a) large atypical polyploid nucleus of about 14-64 μm in size, or multiple nuclei in a single cell; (b) cell size of about 20-300 μm in size; and (c) morphological shape selected from the group consisting of spindle, tadpole, round, oblong, two legs, more than two legs, thin legs, and amorphous; optionally wherein the CAMLs have one or more of the following additional characteristics: (d) CD14 positive phenotype; (e) CD45 expression; (f) EpCAM expression; (g) vimentin expression; (h) PD-L1 expression; (i) CD11C marker expression; (j) CD146 marker expression; (k) CD202b marker expression; (l) CD31 marker expression; and (m) CK8, 18, 19 epithelial phenotype, (a) large atypical polyploid nucleus of about 14-64 μm in size, or multiple nuclei in a single cell; (b) cell size of about 20-300 μm in size; and (c) morphological shape selected from the group consisting of spindle, tadpole, round, oblong, two legs, more than two legs, thin legs, and amorphous; optionally wherein the CAMLs have one or more of the following additional characteristics: (d) CD14 positive phenotype; (e) CD45 expression; (f) EpCAM expression; (g) vimentin expression; (h) PD-L1 expression; (i) CD11C marker expression; (j) CD146 marker expression; (k) CD202b marker expression; (l) CD31 marker expression; and (m) CK8, 18, 19 epithelial phenotype, (d) CD14 positive phenotype; (e) CD45 expression; (f) EpCAM expression; (g) vimentin expression; (h) PD-L1 expression; (i) CD11C marker expression; (j) CD146 marker expression; (k) CD202b marker expression; (l) CD31 marker expression; and (m) CK8, 18, 19 epithelial phenotype, wherein the source of the biological sample is one or more of peripheral blood, blood, lymph node, bone marrow, cerebral spinal fluid, tissue, and urine, and wherein when at least one CAML cell in said sample has about 10 or more CCR5 clusters: (i) the OS and PFS of the subject is predicted to be shortened, or (ii) the OS and PFS of the subject is predicted to be shorter than a subject having the same type of cancer where none of the cells in a corresponding biological sample has about 10 or more CCR5 clusters. (i) the OS and PFS of the subject is predicted to be shortened, or (ii) the OS and PFS of the subject is predicted to be shorter than a subject having the same type of cancer where none of the cells in a corresponding biological sample has about 10 or more CCR5 clusters.