mhurhangee/ep-ind-claims huggingface dataset:
Abseiling device with a winch mechanism, a rotatably mounted main axis on which a sheave is arranged rotatably for slip-proof guidance of a traction means, and an abseiling mechanism, connected with the sheave in a force-transmitting manner, which is configured to maintain a constant abseiling speed of the load suspended on the traction means, wherein the winch mechanism has an operating mechanism which is connected via a force transmission path with the sheave for manual rotation of the sheave, wherein at least one ratchet mechanism with a toothed gear wheel and pawls (32, 34) is arranged in a force transmission path between the operating element of the winch mechanism and the sheave, wherein the ratchet mechanism is switchable at least between a first state and a second state, wherein the gear wheel and pawls (32, 34) are configured such that, in the first state of the ratchet mechanism, in a first direction of rotation of the operating mechanism this is connected in a force-transmitting manner with the sheave via the respective ratchet mechanism, and in an opposite second direction of rotation of the operating mechanism this is freely rotatable relative to the sheave, wherein the operating mechanism has at least one lever arm which is arranged such that this lever arm introduces rotary forces into the force transmission path between the sheave and the operating mechanism via the ratchet mechanism, characterised in that in the second state of the respective ratchet mechanism the pawls (32, 34) are arranged out of engagement with the gearing of the gear wheel so that the ratchet mechanism is freely rotatable relative to the sheave in the first and second direction of rotation (38, 36) of the operating mechanism.
A system comprising, a camera (102, 202) including a curved sensor (104, 304, 404, 504, 604), the curved sensor (104, 304, 404, 504, 604) configured to be rotated about or substantially about a center of curvature of the curved sensor (104, 304, 404, 504, 604) in at least one direction, and an anti-shake correction controller (106, 206), the anti-shake correction controller (106, 206) configured to receive input data corresponding to camera movement (108, 208), and to cause movement of the curved sensor (104, 304, 404, 504, 604) in at least one rotational direction about or substantially about a centre of curvature to correct for at least some of the camera movement (108, 208), wherein the controller (106, 206) is further configured to cause translational movement of the curved sensor (104, 304, 404, 504, 604).
A method comprising: accessing a first depth picture that corresponds to a first video picture; determining, for a given portion of the first depth picture, a co-located video portion of the first video picture; accessing a video motion vector indicating motion of the co-located video portion of the first video picture with respect to a second video picture; accessing a second depth picture that corresponds to the second video picture; determining a depth portion of the second depth picture, from the given portion of the first depth picture, based on the video motion vector; and updating the given portion of the first depth picture based on the depth portion of the second depth picture, wherein the second video picture has a timestamp different from a timestamp of the first video picture, and wherein updating the given portion of the first depth picture comprises applying one or more of temporal weighted averaging and median filtering to values of one or more of the given portion of the first depth picture or the depth portion of the second depth picture (1425, 1435). accessing a first depth picture that corresponds to a first video picture; determining, for a given portion of the first depth picture, a co-located video portion of the first video picture; accessing a video motion vector indicating motion of the co-located video portion of the first video picture with respect to a second video picture; accessing a second depth picture that corresponds to the second video picture; determining a depth portion of the second depth picture, from the given portion of the first depth picture, based on the video motion vector; and updating the given portion of the first depth picture based on the depth portion of the second depth picture, wherein the second video picture has a timestamp different from a timestamp of the first video picture, and wherein updating the given portion of the first depth picture comprises applying one or more of temporal weighted averaging and median filtering to values of one or more of the given portion of the first depth picture or the depth portion of the second depth picture (1425, 1435).
An optical element formed from a material transparent to visible light, and including a cylindrical light guide portion having one end on a light source side along a central axis, a hemispherical scattering portion integrally connected to the other end of the light guide portion along the central axis, wherein a cylindrical inside of the light guide portion is smoothly connected to a hollow inside of the scattering portion to form a cavity, wherein the light guide portion has the same outer diameter as the scattering portion; charactered in that of the inner surface of the cavity, the inner surface of the scattering portion is a diffusing surface which scatters light and wherein the inner surface of the cavity except for the diffusing surface is a mirror surface; wherein an inner surface of the cavity located in the scattering portion has a shape in which a boundary line of the cavity along which a plane including the central axis intersects the inner surface includes a curve portion expanding toward the exterior of the optical element, and when an origin is set in the cavity, a clockwise direction around the origin along the boundary line is set as a positive direction, a first tangent vector is set at a first point on the boundary line, and a second tangent vector is set at a second point adjacent to the first point in the positive direction, an angle defined by the second tangent vector with respect to the first tangent vector with the clockwise direction being a positive direction is not less than 0°.
Paper comprising a fibrous substrate comprising at least one face covered with at least one layer, said layer comprising or consisting of: - 100 parts by dry weight of pigments, - 5 to 50 parts in dry weight of one or more acrylic binders whose glass transition temperature is less than equal to 20 °C, in particular less than equal to 10 °C, - 0 to 15 parts in dry weight of viscosifying agent, such as polyvinyl alcohol, characterized in that the fibrous substrate comprises 70 to 90 % in dry weight of short cellulose fibres with a mean length comprised in a range of 0.5 to 1.5 mm, such as wood fibres, in particular wood fibres obtained from a bleached chemical pulp of eucalyptus and 10 to 30 % by weight of at least one mineral filler, preferably calcium calbonate, kaolin, or titanium dioxide. - 100 parts by dry weight of pigments, - 5 to 50 parts in dry weight of one or more acrylic binders whose glass transition temperature is less than equal to 20 °C, in particular less than equal to 10 °C, - 0 to 15 parts in dry weight of viscosifying agent, such as polyvinyl alcohol,
Composition based on zirconium oxide and on at least one oxide of a rare earth other than cerium, rare earth which is selected from the group consisting of yttrium, lanthanum, neodymium, praseodymium and gadolinium, in a weight proportion of zirconium oxide of at least 70%, the proportion of oxide of rare earth other than cerium being between 10% and 30% and the composition not containing cerium oxide, characterized in that it exhibits, after calcination at a temperature of 900°C for 4 hours, two populations of pores of which the respective diameters are centred, for the first population, about a value of between 20 and 40 nm and, for the second population, about a value of between 80 nm and 200 nm and in that, after calcination at 1100°C for 4 hours, it has a specific surface area of at least 25 m 2 /g.
A method for the positioning of locking devices for components made of wood, plastic or the like, in particular panels, in a machine comprising a base defining a substantially horizontal support surface, a plurality of locking devices of different types, which are designed to be placed on the support surface in order to hold at least one component, and an operating head to process the component; the method being characterized in that it comprises the steps of: associating each type of locking device with a relative type of component and/or with a relative type of processing to be carried out on the component; associating the different types of locking devices with respective position indicators with different colours; selecting the type of locking device depending on the type of component and/or on the type of processing to be carried out on the component; and projecting the position indicator corresponding to the selected type of locking device onto the support surface. associating each type of locking device with a relative type of component and/or with a relative type of processing to be carried out on the component; associating the different types of locking devices with respective position indicators with different colours; selecting the type of locking device depending on the type of component and/or on the type of processing to be carried out on the component; and projecting the position indicator corresponding to the selected type of locking device onto the support surface.
A Motor vehicle latch comprising: a locking mechanism having a catch and at least one pawl, a latch plate for accommodating the locking mechanism, whereby the latch plate has an inlet area, whereby a latch holder can be inserted to interact with the locking mechanism in the inlet area and whereby the latch plate has at least one deformation formed in a peripheral area of the inlet area, in particular a bead, wherein the deformation is at least partly arranged directly on an edge of the inlet area, characterized in that the deformation demonstrates a first splay and in that the deformation is formed from at least a further second splay opposite the first splay so that a cross-sectional profile is formed as a U shape. a locking mechanism having a catch and at least one pawl, a latch plate for accommodating the locking mechanism, whereby the latch plate has an inlet area, whereby a latch holder can be inserted to interact with the locking mechanism in the inlet area and whereby the latch plate has at least one deformation formed in a peripheral area of the inlet area, in particular a bead, wherein the deformation is at least partly arranged directly on an edge of the inlet area,
Method for synthesis of racemic nebivolol represented by formula from the enantiomerically-pure compounds represented by formula IVa and IVb whereby racemic nebivolol is obtained through mixing the enantiomerically-pure compounds d-nebivolol (Ia) and l-nebivolol (Ib), the compounds d-nebivolol ( Ia) and l-nebivolol ( Ib) are synthesised independent of each other as enantiomerically-pure compounds through producing ( Ia) and ( Ib) each through individual coupling of the 4 enantiomerically-pure intermediates represented by formula ( IIa-d) to the corresponding precursors represented by formula ( IIIa-d); whereby d-nebivolol ( Ia) is obtained through coupling ( IIa) to ( IIIb) or ( IIb) to ( IIIa) and l-nebivolol ( Ib) is obtained through coupling ( IIc) to ( IIId) or ( IId) to ( IIIc), and PG in the intermediates represented by formula ( IIa-d) is a hydrogen atom or an amine protection group, and X in the precursors represented by formula ( IIIa-d) is a halogen atom, a hydroxyl group, an acyl group, an alkylsulfonyloxy group or an arylsulfonyloxy group, the intermediates represented by formula ( IIa-d) are formed individually from the respective direct precursors represented by formula ( IIIa-d), whereby intermediate ( IIa) is formed from ( IIIa), intermediate ( IIb) is formed from ( IIIb), intermediate ( IIc) is formed from ( IIIc), and intermediate ( IId) is formed from ( IIId); the precursors represented by formula ( IIIa-d) are formed specifically through reduction of the enantiomerically-pure ketone precursors represented by formula ( IVa,b), whereby the precursors represented by formula ( IIIa) and ( III-d) originate from the ketone precursor represented by formula ( IVa), and the precursors represented by formula ( IIIb) and ( IIIc) originate from the ketone precursor represented by formula ( IVb), and Z in the ketone precursors ( IVa,b) is a halogen atom, a hydroxyl function, an acyl group, an alkylsulfonyloxy group or an arylsulfonyloxy group.
A pigment, comprising a plate-like substrate of glass having an average thickness of < 1 μm, especially of from 20 nm to 400 nm, and (a) a dielectric material, especially a metal oxide, having a high index of refraction, that is to say an index of refraction of greater than 1.65; or (a) a metal layer, especially a thin semi-transparent metal layer, wherein the glass substrate consists of ECR glass having > 0.1 % TiO 2 and wherein the composition of the ECR glass is as follows: SiO 2 (63-70 %), Al 2 O 3 (3-6 %), CaO (4-7 %), MgO (1-4%), B 2 O 3 (2-5 %), Na 2 O (9-12 %), K 2 O (0-3 %), TiO 2 (>0.1-4 %), ZnO (1-5%). (a) a dielectric material, especially a metal oxide, having a high index of refraction, that is to say an index of refraction of greater than 1.65; or (a) a metal layer, especially a thin semi-transparent metal layer, wherein the glass substrate consists of ECR glass having > 0.1 % TiO 2 and wherein the composition of the ECR glass is as follows: SiO 2 (63-70 %), Al 2 O 3 (3-6 %), CaO (4-7 %), MgO (1-4%), B 2 O 3 (2-5 %), Na 2 O (9-12 %), K 2 O (0-3 %), TiO 2 (>0.1-4 %), ZnO (1-5%).
A cuvette for an automatic incubator, said cuvette comprising: - at least two vessels, connected by - a separating wall, the number of which is totally one less than the number of the at least two vessels, said walls allowing for the elastic bending of the cuvette about its vertical axis, and - brackets, which are located in the outermost vessels and adapted to guide the cuvette into a curved shape, characterized in that the brackets comprise flexible protrusions, which curve outwards from the upper edges of the outer corners of the outermost vessels and curve towards each other, the direction oriented outward being the horizontal direction oriented from the separating wall toward the outer edge of an outermost vessel, whereby the brackets are adapted to be elastic in the vessel orientation direction and to be torsionally rigid in the vertical direction. - at least two vessels, connected by - a separating wall, the number of which is totally one less than the number of the at least two vessels, said walls allowing for the elastic bending of the cuvette about its vertical axis, and - brackets, which are located in the outermost vessels and adapted to guide the cuvette into a curved shape,
An anti-cMet antibody drug conjugate for use in a method of treating a non-small cell lung cancer (NSCLC) that overexpresses cMet, the method comprising administering to a subject having said NSCLC the ADC in an amount and for a period of time sufficient to provide a therapeutic benefit; wherein the drug conjugate is monomethyl auristatin E ("MMAE"); and the ADC has the following structure: wherein n has a value ranging from 2 to 8; and the Ab is an anti-cMet antibody comprising a VH chain comprising three CDRs, namely VH CDR #1 (SEQ ID NO: 112), VH CDR #2 (SEQ ID NO:1 13) and VH CDR #3 (SEQ ID NO: 114); a VL chain comprising three CDRs, namely VL CDR #1 (SEQ ID NO: 115), VL CDR #2 (SEQ ID NO: 116) and VL CDR #3 (SEQ ID NO: 117); and a modified hinge region of SEQ ID NO: 170. n has a value ranging from 2 to 8; and the Ab is an anti-cMet antibody comprising a VH chain comprising three CDRs, namely VH CDR #1 (SEQ ID NO: 112), VH CDR #2 (SEQ ID NO:1 13) and VH CDR #3 (SEQ ID NO: 114); a VL chain comprising three CDRs, namely VL CDR #1 (SEQ ID NO: 115), VL CDR #2 (SEQ ID NO: 116) and VL CDR #3 (SEQ ID NO: 117); and a modified hinge region of SEQ ID NO: 170.
A vehicle configured such that, when moving at a speed above a predetermined threshold speed, at least one turbulent and/or low pressure region is formed adjacent to the vehicle, the vehicle comprising: at least one propelling nozzle located adjacent to the at least one region, characterised in that the at least one propelling nozzle comprises: at least one convergent propelling nozzle located adjacent to a boundary of the at least one region; and at least one divergent propelling nozzle located adjacent to the at least one region and spaced from the boundary of the at least one region; and wherein the vehicle comprises a system for providing gas to each of the at least one convergent and divergent propelling nozzles for expulsion into the at least one region. at least one propelling nozzle located adjacent to the at least one region, characterised in that the at least one propelling nozzle comprises: at least one convergent propelling nozzle located adjacent to a boundary of the at least one region; and at least one divergent propelling nozzle located adjacent to the at least one region and spaced from the boundary of the at least one region; and at least one convergent propelling nozzle located adjacent to a boundary of the at least one region; and at least one divergent propelling nozzle located adjacent to the at least one region and spaced from the boundary of the at least one region; and wherein the vehicle comprises a system for providing gas to each of the at least one convergent and divergent propelling nozzles for expulsion into the at least one region.
A wind turbine blade comprising - one or more shape deformable airfoil sections wherein the outer surface of each of the shape deformable airfoil sections is substantially continuous in all of its shapes, each shape deformable airfoil section comprises a substantially non-deformable part and one or more deformable parts (10,12), and - actuator means (24,28,30) for providing the shape changes in the shape deformable airfoil sections, the actuator means (24,28,30) are(is) active means in the sense that they(it) provide(s) changes in shape by supplying them(it) with energy, wherein - the outer surface of at least one of the deformable parts (10,12) is defined by a skin made of a flexible material, e.g. rubber, and wherein the skin is attached to the substantially non-deformable part and wherein the actuator means is situated within the skin, or wherein- at least one of the shape deformable parts (10,12) is made of flexible material(s), e.g. rubber, the actuator means is(are) an extendable beam(s) extending within the material(s), and the extendable beam(s) is(are) made from a material composition which elongation(s), shortening(s) and/or bending(s) is(are) controllable by applied electrical current(s), such as made from a smart material. - one or more shape deformable airfoil sections wherein the outer surface of each of the shape deformable airfoil sections is substantially continuous in all of its shapes, each shape deformable airfoil section comprises a substantially non-deformable part and one or more deformable parts (10,12), and - actuator means (24,28,30) for providing the shape changes in the shape deformable airfoil sections, the actuator means (24,28,30) are(is) active means in the sense that they(it) provide(s) changes in shape by supplying them(it) with energy, - the outer surface of at least one of the deformable parts (10,12) is defined by a skin made of a flexible material, e.g. rubber, and wherein the skin is attached to the substantially non-deformable part and wherein the actuator means is situated within the skin,
A novel process for the preparation of a alkyl lactyl lactate comprising the following steps: a) stirring the reaction mixture of alkyl lactate, condensing reagents in anhydrous solvent at 0°C; b) adding a solution of lactic acid in solvent to a reaction mixture of step (a) slowly over a period of 1 to 3 hours; c) stirring the reaction mixture at temperature 27°C for 10 to 12 hours to afford the product of monomer of alkyl lactyl lactate. a) stirring the reaction mixture of alkyl lactate, condensing reagents in anhydrous solvent at 0°C; b) adding a solution of lactic acid in solvent to a reaction mixture of step (a) slowly over a period of 1 to 3 hours; c) stirring the reaction mixture at temperature 27°C for 10 to 12 hours to afford the product of monomer of alkyl lactyl lactate.
A method for building up a profile of autoantibody production in a mammalian subject, wherein said autoantibody is a biological marker of a disease state or disease susceptibility, which method comprises: (a) preparing two or more different dilutions of a test sample comprising a bodily fluid from said mammalian subject and carrying out the following steps (i) and (ii) in respect of each test sample dilution: (i) contacting the test sample dilution with a plurality of different amounts of an antigen specific for said antibody, (ii) detecting the amount of specific binding between the antibody and the antigen for each amount of antigen used in step (i), (b) plotting or calculating a separate curve of the amount of specific binding versus the amount of antigen for each test sample dilution used in step (a), to build up a profile of antibody production in said subject either prior to the onset of disease, or throughout the course of disease. (a) preparing two or more different dilutions of a test sample comprising a bodily fluid from said mammalian subject and carrying out the following steps (i) and (ii) in respect of each test sample dilution: (i) contacting the test sample dilution with a plurality of different amounts of an antigen specific for said antibody, (ii) detecting the amount of specific binding between the antibody and the antigen for each amount of antigen used in step (i), (i) contacting the test sample dilution with a plurality of different amounts of an antigen specific for said antibody, (ii) detecting the amount of specific binding between the antibody and the antigen for each amount of antigen used in step (i), (b) plotting or calculating a separate curve of the amount of specific binding versus the amount of antigen for each test sample dilution used in step (a), to build up a profile of antibody production in said subject either prior to the onset of disease, or throughout the course of disease.