A novel multi-ingredient combination topical anti-aging and skin rejuvenation composition targeting all categories of skin aging the composition comprising: a cream base component and, for each 28.36 g (for each ounce) of cream base component, in percentages by weight: between 0.50 and 2.00% of the ergothioneine; between 0.10 and 2.00% of the resveratrol; between 0.01 and 5.00% of the acetyl tetrapeptide-2; between 0.50 and 4.00% of ferulic acid; between 0.10 and 3.00% of the Coffea Arabica seed extract; between 0.10 and 2.00% of the Ilex Paraguariensis Leaf extract; between 0.10 and 2.00% of the Chrysanthemum Parthenium extract; between 0.10 and 1.00% of the caffeine; between 0.10 and 1.00% of the bisabolol; between 0.10 and 2.00% of the Tremella fuciformis extract; between 0.10 and 2.00% of the tetrahexyldecyl ascorbate; between 0.01 and 1.00% of the magnesium ascorbyl phosphate; between 0.01 and 0.50% tocopherol; between 0.10 and 2.00% sodium hyaluronate between 10 and 200 kDa; between 0.01 and 1.00% of arginine; between 0.01 and 1.00% of aspartic acid; between 0.01 and 1.00% of glycine; between 0.01 and 1.00% of alanine; between 0.01 and 1.00% of serine; between 0.01 and 1.00% of valine; between 0.01 and 1.00% of proline; between 0.01 and 1.00% of threonine; between 0.01 and 1.00% of isoleucine; between 0.01 and 1.00% of histidine; between 0.01 and 1.00% of phenylalanine; and/or other amino acid; between 0.01 and 1.00% of acetyl tyrosine; between 0.01 and 3.00% of squalane; between 0.50 and 2.00% vegetable protein; between 0.01 and 1.00% Arabidopsis thaliana extract; between 0.01 and 5.00% of adenosine triphosphate; between 0.10 and 2.00% lecithin; between 0.10 and 3.00% Philodendron amurense extract; or alternatively phloretin; between 0.10 and 1.00% Santalum album extract; between 0.10 and 5.00% Hordeum distichon extract; between 0.50 and 7.00% glycerin; between 1.00 and 10.00% dimethicone; between 0.10 and 3.00% soy protein; between 0.01 and 5.00% of sodium lactate; between 0.10 and 5.00% Helianthus annus (sunflower) seed extract. between 0.50 and 2.00% of the ergothioneine; between 0.10 and 2.00% of the resveratrol; between 0.01 and 5.00% of the acetyl tetrapeptide-2; between 0.50 and 4.00% of ferulic acid; between 0.10 and 3.00% of the Coffea Arabica seed extract; between 0.10 and 2.00% of the Ilex Paraguariensis Leaf extract; between 0.10 and 2.00% of the Chrysanthemum Parthenium extract; between 0.10 and 1.00% of the caffeine; between 0.10 and 1.00% of the bisabolol; between 0.10 and 2.00% of the Tremella fuciformis extract; between 0.10 and 2.00% of the tetrahexyldecyl ascorbate; between 0.01 and 1.00% of the magnesium ascorbyl phosphate; between 0.01 and 0.50% tocopherol; between 0.10 and 2.00% sodium hyaluronate between 10 and 200 kDa; between 0.01 and 1.00% of arginine; between 0.01 and 1.00% of aspartic acid; between 0.01 and 1.00% of glycine; between 0.01 and 1.00% of alanine; between 0.01 and 1.00% of serine; between 0.01 and 1.00% of valine; between 0.01 and 1.00% of proline; between 0.01 and 1.00% of threonine; between 0.01 and 1.00% of isoleucine; between 0.01 and 1.00% of histidine; between 0.01 and 1.00% of phenylalanine; and/or other amino acid; between 0.01 and 1.00% of acetyl tyrosine; between 0.01 and 3.00% of squalane; between 0.50 and 2.00% vegetable protein; between 0.01 and 1.00% Arabidopsis thaliana extract; between 0.01 and 5.00% of adenosine triphosphate; between 0.10 and 2.00% lecithin; between 0.10 and 3.00% Philodendron amurense extract; or alternatively phloretin; between 0.10 and 1.00% Santalum album extract; between 0.10 and 5.00% Hordeum distichon extract; between 0.50 and 7.00% glycerin; between 1.00 and 10.00% dimethicone; between 0.10 and 3.00% soy protein; between 0.01 and 5.00% of sodium lactate; between 0.10 and 5.00% Helianthus annus (sunflower) seed extract.