Process for the preparation of substituted pyridine derivatives of formula wherein R 1, R 2 independently the same or different are H; C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; R 3 = CN, NO 2, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; R 4 = E n R 8 m In which If n = m =1 then E = S and R 6 = C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F, Cl, Br, I; If n = 0 and m = 1 then R 6 = H, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F, Cl, Br, I; E 1 =O, N R 6 =H n=1 for E 1 = O und 2 for E 1 = N comprising reaction of a α-β-unsaturated carbonyl compound of formula R 3 -C -C(R 1)=C(R 2)-G wherein R 1, R 2 and R 3 have the above defined meaning; G = -NH 2 or a leaving group with a Horner-Wadsworth-Emmons reagent of formula (IIIb2) wherein R' = is equal or different independently means C 1-20 alkyl, branched or straight or cyclic, or C 8-20 aryl; E n R 8 m = in which If n = m = 1 then E = S and R 8 = C 1-20 -alkyl (branched or straight chain or cyclic); C 8-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; if n = 0 and m = 1 then R 6 = H, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the followin groups: F, Cl, Br, I, C 1-20 -alkoxy, C 8-20 -aryloxy, amino; F; Cl; Br; I; Y = - CN; -C NH 2; -C OR 7 with R 7 = as defined for R 1 above, except H in the presence of a base and if i) Y = -CN or C NH 2, G = a leaving group and the base is an alcoholate, subsequent acidic catalyzed, with zeolithes catalyzed or basic catalyzed cyclization; ii) Y = -C -OR 7, G = a leaving group and the base is an alcoholate, subsequent basic cyclization in the presence of ammonia. R 1, R 2 independently the same or different are H; C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; R 3 = CN, NO 2, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; R 4 = E n R 8 m In which If n = m =1 then E = S and R 6 = C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F, Cl, Br, I; If n = 0 and m = 1 then R 6 = H, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F, Cl, Br, I; E 1 =O, N R 6 =H n=1 for E 1 = O und 2 for E 1 = N R 1, R 2 and R 3 have the above defined meaning; G = -NH 2 or a leaving group R' = is equal or different independently means C 1-20 alkyl, branched or straight or cyclic, or C 8-20 aryl; E n R 8 m = in which If n = m = 1 then E = S and R 8 = C 1-20 -alkyl (branched or straight chain or cyclic); C 8-20 -aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-20 -aryloxy, amino; F; Cl; Br; I; if n = 0 and m = 1 then R 6 = H, C 1-20 -alkyl (branched or straight chain or cyclic); C 6-20 -aryl - which each of those may be substituted with one or more of the followin groups: F, Cl, Br, I, C 1-20 -alkoxy, C 8-20 -aryloxy, amino; F; Cl; Br; I; Y = - CN; -C NH 2; -C OR 7 with R 7 = as defined for R 1 above, except H i) Y = -CN or C NH 2, G = a leaving group and the base is an alcoholate, subsequent acidic catalyzed, with zeolithes catalyzed or basic catalyzed cyclization; ii) Y = -C -OR 7, G = a leaving group and the base is an alcoholate, subsequent basic cyclization in the presence of ammonia.