A compound of Formula I, including pharmaceutically acceptable salts thereof: wherein: R 1a and R 1b are each independently selected from hydrogen, alkyl, aryl, arylalkyl, aryloxyaryl, cycloalkyl, heterocyclyl, heterocyclylalkyl, and -alkylCO(R x); wherein said heterocyclyl is linked to the parent molecule through a carbon atom, and further wherein said R 1a and R 1b groups are substituted with 0-4 groups independently selected from alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkylthioxy, benzyloxy, alkynyl, aryl, arylalkyl, aryloxy, carboxylic acid, cyano, cycloalkyl, halo, haloalkyl, haloalkoxy, heterocyclyl, heterocylyl alkyl, hydroxy, hydroxyalkyl, thioxy, -CH 2 NH 2, -alkyl-heteroaryl, -CO-alkyl, CO(R x), -CON(R y) 2, -NHCON(R y) 2, -NHCO-alkyl, -NHCO 2 alkyl, -NHSO 2 -alkyl, -OCH 2 -aryl, -SO 2 -alkyl, -SO 2 -N(R y) 2, and -SO 2 -heterocyclyl; or R 1a and R 1b together with the nitrogen atom to which they are attached form a heterocycle that is substituted with 0-4 groups independently selected from alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkylthioxy, benzyloxy, alkynyl, aryl, carboxylic acid, cyano, halo, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, thioxy, -CH 2 NH 2, -alkyl-heteroaryl, -CO-alkyl, -CO(R x), -CON(R y) 2, -N(R y)CON(R y) 2, -N(R y)CO-alkyl, -N(R y)CO 2 alkyl, - N(R y)SO 2 -alkyl, -OCH 2 -aryl, -SO 2 -alkyl, -SO 2 -N(R y) 2, and -SO 2 -heterocyclyl; R 2 is -H, C 1 -C 4 alkyl or C 3 -C 4 cycloalkyl; R 3 is -H, C 1 -C 4 alkyl or C 3 -C 4 cycloalkyl; R 4 is -H, alkyl, aryl, C 5 -C 10 bicycloalkyl, C 3 -C 7 cycloalkyl or heteroaryl with 0-4 groups independently selected from alkenoxy, alkenyl, alkoxy, alkoxycarbonyl, alkyl, benzyloxy, carboamide, cyano, halo, haloalkyl, haloalkyloxy, -NHCO(alkyl), -SO 2 (R x), -OH, and - CH 2 OH; R 5 and R 6 are independently H or alkyl, or R 5 and R 6 together with the atoms to which they are attached form a C 3 -C 4 cycloalkyl; R 7 is -H, alkyl, aryl, heterocyclyl, or C 3 -C 7 cycloalkyl, wherein said aryl or heterocyclyl is substituted with 0-3 groups selected from -OH, -NHCOalkyl, -NHCON(alkyl) 2, - NHCO 2 -alkyl, -CONH 2, -CN, -SO 2 N(alkyl) 2, alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; R 8 is -H, alkyl, cycloalkyl, haloalkyl, halocycloalkyl, alkenyl, or aryloxyalkyl; or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycle that is substituted with 0-4 groups independently selected from -OH, - NHCOalkyl, -NHCON(alkyl) 2, -NHCO 2 -alkyl, -CONH 2, -CN, -SO 2 N(alkyl) 2, alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; R x is dialkylamine or a nitrogen-containing heterocycle which is attached to the parent fragment through a nitrogen atom; and each R y is independently hydrogen, alkyl, haloalkyl or aryl. R 1a and R 1b are each independently selected from hydrogen, alkyl, aryl, arylalkyl, aryloxyaryl, cycloalkyl, heterocyclyl, heterocyclylalkyl, and -alkylCO(R x); wherein said heterocyclyl is linked to the parent molecule through a carbon atom, and further wherein said R 1a and R 1b groups are substituted with 0-4 groups independently selected from alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkylthioxy, benzyloxy, alkynyl, aryl, arylalkyl, aryloxy, carboxylic acid, cyano, cycloalkyl, halo, haloalkyl, haloalkoxy, heterocyclyl, heterocylyl alkyl, hydroxy, hydroxyalkyl, thioxy, -CH 2 NH 2, -alkyl-heteroaryl, -CO-alkyl, CO(R x), -CON(R y) 2, -NHCON(R y) 2, -NHCO-alkyl, -NHCO 2 alkyl, -NHSO 2 -alkyl, -OCH 2 -aryl, -SO 2 -alkyl, -SO 2 -N(R y) 2, and -SO 2 -heterocyclyl; or R 1a and R 1b together with the nitrogen atom to which they are attached form a heterocycle that is substituted with 0-4 groups independently selected from alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkylthioxy, benzyloxy, alkynyl, aryl, carboxylic acid, cyano, halo, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, thioxy, -CH 2 NH 2, -alkyl-heteroaryl, -CO-alkyl, -CO(R x), -CON(R y) 2, -N(R y)CON(R y) 2, -N(R y)CO-alkyl, -N(R y)CO 2 alkyl, - N(R y)SO 2 -alkyl, -OCH 2 -aryl, -SO 2 -alkyl, -SO 2 -N(R y) 2, and -SO 2 -heterocyclyl; R 2 is -H, C 1 -C 4 alkyl or C 3 -C 4 cycloalkyl; R 3 is -H, C 1 -C 4 alkyl or C 3 -C 4 cycloalkyl; R 4 is -H, alkyl, aryl, C 5 -C 10 bicycloalkyl, C 3 -C 7 cycloalkyl or heteroaryl with 0-4 groups independently selected from alkenoxy, alkenyl, alkoxy, alkoxycarbonyl, alkyl, benzyloxy, carboamide, cyano, halo, haloalkyl, haloalkyloxy, -NHCO(alkyl), -SO 2 (R x), -OH, and - CH 2 OH; R 5 and R 6 are independently H or alkyl, or R 5 and R 6 together with the atoms to which they are attached form a C 3 -C 4 cycloalkyl; R 7 is -H, alkyl, aryl, heterocyclyl, or C 3 -C 7 cycloalkyl, wherein said aryl or heterocyclyl is substituted with 0-3 groups selected from -OH, -NHCOalkyl, -NHCON(alkyl) 2, - NHCO 2 -alkyl, -CONH 2, -CN, -SO 2 N(alkyl) 2, alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; R 8 is -H, alkyl, cycloalkyl, haloalkyl, halocycloalkyl, alkenyl, or aryloxyalkyl; or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycle that is substituted with 0-4 groups independently selected from -OH, - NHCOalkyl, -NHCON(alkyl) 2, -NHCO 2 -alkyl, -CONH 2, -CN, -SO 2 N(alkyl) 2, alkoxy, alkyl, halo, haloalkoxy, and haloalkyl; R x is dialkylamine or a nitrogen-containing heterocycle which is attached to the parent fragment through a nitrogen atom; and each R y is independently hydrogen, alkyl, haloalkyl or aryl.