A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual geometrical isomers tautomers or a pharmaceutically acceptable salt thereof: wherein: R 1 is H or substituted or unsubstituted C 1-6 alkyl; R 2 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted OC 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or substituted or unsubstituted C 6-10 aryl; R 3 is C-R 7; R 4 is C-R 8; R 5 is -P R 10; R 6 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or substituted or unsubstituted C 6-10 aryl; R 7 is H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl, substituted or unsubstituted C 6-10 aryl, halogen, substituted or unsubstituted -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, - substituted or unsubstituted OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl or C R 12; R 10 is H, substituted or unsubstituted C 1-6 alkyl, OH, OC 1-6 alkyl or HNC 1-3 alkyl; R 12 is H or substituted or unsubstituted C 1-6 alkyl; R 13 is H or substituted or unsubstituted C 1-6 alkyl; R 14 is H or substituted or unsubstituted C 1-6 alkyl; R 15 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; and R 16 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl. R 1 is H or substituted or unsubstituted C 1-6 alkyl; R 2 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted OC 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or substituted or unsubstituted C 6-10 aryl; R 3 is C-R 7; R 4 is C-R 8; R 5 is -P R 10; R 6 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl or substituted or unsubstituted C 6-10 aryl; R 7 is H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted C 3-8 cycloalkenyl, substituted or unsubstituted C 6-10 aryl, halogen, substituted or unsubstituted -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; R 8 is H, substituted or unsubstituted C 1-6 alkyl, halogen, - substituted or unsubstituted OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl or C R 12; R 10 is H, substituted or unsubstituted C 1-6 alkyl, OH, OC 1-6 alkyl or HNC 1-3 alkyl; R 12 is H or substituted or unsubstituted C 1-6 alkyl; R 13 is H or substituted or unsubstituted C 1-6 alkyl; R 14 is H or substituted or unsubstituted C 1-6 alkyl; R 15 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl; and R 16 is H, substituted or unsubstituted C 1-6 alkyl, halogen, -OC 1-6 alkyl, CN, C 2-6 alkenyl, C 2-6 alkynyl, C R 12, NR 13 R 14 or hydroxyl.