mhurhangee/ep-ind-claims huggingface dataset:
A variant adeno-associated virus capsid protein comprising a peptide insertion of from 7 amino acids to 20 amino acids in the GH-loop of the capsid protein relative to a corresponding parental AAV capsid protein that is the same AAV capsid protein of the same wild-type AAV serotype as the variant AAV capsid protein but that does not comprise the peptide insertion of the variant AAV capsid protein, wherein the peptide insertion comprises the amino acid sequence NKIQRTD (SEQ ID NO: 13), wherein the insertion site is located between two adjacent amino acids at a position between amino acids 570 and 611 of VP1 of AAV2 (SEQ ID NO:2), or the corresponding position in the capsid protein of another AAV serotype wherein the insertion site is located within: (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; wherein the variant capsid protein, when present in an AAV virion, confers increased infectivity of a muscle cell compared to the infectivity of a muscle cell by an AAV virion comprising the corresponding parental AAV capsid protein. wherein the peptide insertion comprises the amino acid sequence NKIQRTD (SEQ ID NO: 13), wherein the insertion site is located between two adjacent amino acids at a position between amino acids 570 and 611 of VP1 of AAV2 (SEQ ID NO:2), or the corresponding position in the capsid protein of another AAV serotype wherein the insertion site is located within: (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; wherein the variant capsid protein, when present in an AAV virion, confers increased infectivity of a muscle cell compared to the infectivity of a muscle cell by an AAV virion comprising the corresponding parental AAV capsid protein.
Permanent magnetic material comprising 40.0 to 59.8 % manganese; 40.0 to 59.8 % aluminum; wherein the percentages relate to the mole fractions of the respective component in the permanent magnetic material, characterised by further comprising 0.2 to 2.0 % scandium. 40.0 to 59.8 % manganese; 40.0 to 59.8 % aluminum; wherein the percentages relate to the mole fractions of the respective component in the permanent magnetic material, characterised by further comprising 0.2 to 2.0 % scandium.
A cache system, comprising: a cache core server, configured to send information about a Transmission Control Protocol flow; and a cache edge server, configured to receive the information from the cache core server to determine, according to the information, whether the cache edge server stores a content corresponding to the information, and send a migrate-out request to the cache core server based on that the cache edge server stores the content corresponding to the information; wherein the cache core server is further configured to: based on the migrate-out request, disable a Transmission Control Protocol connection to user equipment, and transfer a migrate-out response to the cache edge server; and the cache edge server is further configured to perform a Transmission Control Protocol connection to the user equipment according to the migrate-out response, to transfer content to the user equipment by using the Transmission Control Protocol connection. a cache core server, configured to send information about a Transmission Control Protocol flow; and a cache edge server, configured to receive the information from the cache core server to determine, according to the information, whether the cache edge server stores a content corresponding to the information, and send a migrate-out request to the cache core server based on that the cache edge server stores the content corresponding to the information; wherein the cache core server is further configured to: based on the migrate-out request, disable a Transmission Control Protocol connection to user equipment, and transfer a migrate-out response to the cache edge server; and the cache edge server is further configured to perform a Transmission Control Protocol connection to the user equipment according to the migrate-out response, to transfer content to the user equipment by using the Transmission Control Protocol connection.
A dentifrice composition comprising the following components, and: from 0.2 to 3 weight% of powder cellulose; a surfactant; and from 10 to 30 weight% of an abrasive, wherein the abrasive has an RDA of from 20 to 200. from 0.2 to 3 weight% of powder cellulose; a surfactant; and from 10 to 30 weight% of an abrasive,
A co-rotating twin screw extruder for forming fragments comprising an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient; a melt zone for softening at least one excipient to form a viscous mass or melt; and a fragmenting zone for initiating simultaneous fragmentation and cooling of the viscous mass into cooled fragments within the co-rotating twin screw extruder; and an extruder outlet for recovering the cooled fragments from the extruder, wherein the extruder does not include a cooling zone comprising conveying elements between the melt zone and the fragmenting zone.
A gasket material in which a foamed rubber layer having a closed cell structure is formed, via an adhesive layer, on at least one side of a metal plate, wherein the foamed rubber layer comprises a carboxyl group-modified nitrile rubber, the expansion ratio of the foamed rubber layer is 2.0 to 3.0, and the foamed rubber layer is crosslinked with an epoxy compound.
A bipolar electrosurgical system configured to perform an electrosurgical procedure at a treatment site within a patient, the electrosurgical system comprising: an electrosurgical device configured to perform a sphincterotomy for access to the patient's bile duct; and a medical delivery device configured to deliver a distal end of the electrosurgical device to the treatment site, wherein the electrosurgical device comprises an active member that is configured as part of an active path for the bipolar electrosurgical system; and wherein the medical delivery device comprises a return electrode that is at least one of disposed on or integral with an outer surface of the medical delivery device, the return electrode configured as part of a return path for the bipolar electrosurgical system, wherein the return electrode has a longitudinal length such that when a distal portion of the medical delivery device is positioned adjacent to the patient's papillae for the electrosurgical device to perform the sphincterotomy, the return electrode longitudinally extends from the patient's duodenum to the patient's pylorus. an electrosurgical device configured to perform a sphincterotomy for access to the patient's bile duct; and a medical delivery device configured to deliver a distal end of the electrosurgical device to the treatment site, wherein the electrosurgical device comprises an active member that is configured as part of an active path for the bipolar electrosurgical system; and wherein the medical delivery device comprises a return electrode that is at least one of disposed on or integral with an outer surface of the medical delivery device, the return electrode configured as part of a return path for the bipolar electrosurgical system, wherein the return electrode has a longitudinal length such that when a distal portion of the medical delivery device is positioned adjacent to the patient's papillae for the electrosurgical device to perform the sphincterotomy, the return electrode longitudinally extends from the patient's duodenum to the patient's pylorus.
A compound of formula wherein R1 is a C 9 -C 23 acyl, R 2 and R 3 are, independently of each other, H or a heteroarylC 1 -C 6 alkyl, wherein the heteroaryl residue may optionally be substituted with one or more substituents selected from halogen, hydroxy, nitro, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkanoyloxy, R 4 is H or a C 1 -C 6 alkyl, R 5 is an amino acid side chain of a basic amino acid selected from the group of arginine, lysine, histidine, 2,4-diaminobutyric acid, homolysine and ornithine, and R 6 and R 7 are, independently of each other, selected from the group consisting of H, a C 1 -C 12 alkyl and a C 3 -C 6 cycloalkylC 1 -C 3 alkyl, or a cosmetically acceptable salt thereof, and with the proviso that only one of the residues R 2 and R 3 as well as only one of the residues R 6 and R 7 is H and/ or at least one of R 3, R 4 or R 7 is not H. R1 is a C 9 -C 23 acyl, R 2 and R 3 are, independently of each other, H or a heteroarylC 1 -C 6 alkyl, wherein the heteroaryl residue may optionally be substituted with one or more substituents selected from halogen, hydroxy, nitro, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkanoyloxy, R 4 is H or a C 1 -C 6 alkyl, R 5 is an amino acid side chain of a basic amino acid selected from the group of arginine, lysine, histidine, 2,4-diaminobutyric acid, homolysine and ornithine, and R 6 and R 7 are, independently of each other, selected from the group consisting of H, a C 1 -C 12 alkyl and a C 3 -C 6 cycloalkylC 1 -C 3 alkyl,
A method comprising: applying a periodic actuation field to a sample contained in a measurement chamber, the measurement chamber including a sensor with the sensor surface being passivated to prevent sample constituents of the sample from attaching to the surface of sensor, the sample comprising a target analyte, the applied field oscillating with a first frequency;. inducing a periodic variation of a property of target analyte attached to a magnetic bead within the sample through the periodic actuation field, wherein the periodic variation is related to the concentration of the target analyte, wherein the periodic actuation field comprises a magnetic field; measuring an electrical impedance of the sensor, the electrical impedance being indicative of a change of position of the target analyte in response to applying the periodic field, wherein measuring the electrical impedance comprises applying an electrical signal to the electrode pair on the sensor, the electrical signal oscillating with a second frequency distinct from the first frequency; determining a frequency component of the electrical impedance of the sensor at the first frequency; and determining a concentration of the target analyte in the sample according to the frequency component of the electrical impedance at the first frequency applying a periodic actuation field to a sample contained in a measurement chamber, the measurement chamber including a sensor with the sensor surface being passivated to prevent sample constituents of the sample from attaching to the surface of sensor, the sample comprising a target analyte, the applied field oscillating with a first frequency;. inducing a periodic variation of a property of target analyte attached to a magnetic bead within the sample through the periodic actuation field, wherein the periodic variation is related to the concentration of the target analyte, wherein the periodic actuation field comprises a magnetic field; measuring an electrical impedance of the sensor, the electrical impedance being indicative of a change of position of the target analyte in response to applying the periodic field, wherein measuring the electrical impedance comprises applying an electrical signal to the electrode pair on the sensor, the electrical signal oscillating with a second frequency distinct from the first frequency; determining a frequency component of the electrical impedance of the sensor at the first frequency; and determining a concentration of the target analyte in the sample according to the frequency component of the electrical impedance at the first frequency
An engine system comprising: an engine configured to output shaft power by burning fuel; and a system main portion configured to operate using the shaft power of the engine, the engine system further comprising: an operation controlling unit; and a power source unit configured to convert commercial electric power to operating electric power and to supply the operating electric power to the operation controlling unit, wherein the system main portion comprises a fuel shutoff valve capable of shutting off supply of fuel to the engine, and wherein the power source unit comprises: a system main portion-side power source unit configured to supply operating power for controlling operation of the system main portion; and an engine-side power source unit configured to supply operating power for controlling operation of the engine, the system main portion-side power source unit and the engine-side power source unit being provided in a parallel manner, characterized in that the operation controlling unit comprises a system main portion controlling unit and an engine controlling unit which are provided individually and separately, the system main portion controlling unit configured to receive operating power from the system main portion-side power source unit and to control operation of the system main portion, the engine controlling unit configured to receive operating power from the engine-side power source unit and to control operation of the engine. an operation controlling unit; and a power source unit configured to convert commercial electric power to operating electric power and to supply the operating electric power to the operation controlling unit, wherein the system main portion comprises a fuel shutoff valve capable of shutting off supply of fuel to the engine, and wherein the power source unit comprises: a system main portion-side power source unit configured to supply operating power for controlling operation of the system main portion; and an engine-side power source unit configured to supply operating power for controlling operation of the engine, the system main portion-side power source unit and the engine-side power source unit being provided in a parallel manner, characterized in that the operation controlling unit comprises a system main portion controlling unit and an engine controlling unit which are provided individually and separately, the system main portion controlling unit configured to receive operating power from the system main portion-side power source unit and to control operation of the system main portion, the engine controlling unit configured to receive operating power from the engine-side power source unit and to control operation of the engine.
A method in a system comprising a user equipment and a base station, the method comprising: sending an indication from the base station to the user equipment, the indication indicating a set of frequency domain resource blocks for possible physical uplink shared channel transmission in an uplink subframe; and receiving at the base station a physical uplink shared channel in a selected subset of resource blocks in the uplink subframe, where the subset of resource blocks is selected from the set of frequency domain resource blocks for possible physical uplink shared channel transmission based on a selection criterion, wherein the selection criterion uses at least a resource set size acquired from the indication, a modulo function, and an identifier associated with the user equipment. sending an indication from the base station to the user equipment, the indication indicating a set of frequency domain resource blocks for possible physical uplink shared channel transmission in an uplink subframe; and receiving at the base station a physical uplink shared channel in a selected subset of resource blocks in the uplink subframe, where the subset of resource blocks is selected from the set of frequency domain resource blocks for possible physical uplink shared channel transmission based on a selection criterion, wherein the selection criterion uses at least a resource set size acquired from the indication, a modulo function, and an identifier associated with the user equipment.
A method comprising: receiving, by one or more processors, a request to operate a vehicle in an autonomous driving mode; in response to receiving the request, accessing protocol data and using the protocol data to assess, by the one or more processors, (i) the status of the vehicle's environment, (ii) the vehicle, and systems of the vehicle, and (iii) a driver of the vehicle; generating, by the one or more processors, a set of tasks based on a plurality of preventative conditions identified from the assessments, wherein a task of the set of tasks includes closing a door, each task of the set of tasks being assigned a priority level; selecting a first task based on the priority levels of the set of tasks; displaying, by the one or more processors on a display of the vehicle, the first task and one or more other tasks of the set of tasks in an ordered sequence; only upon determining that all of the tasks of the set of tasks are completed, allowing, by the one or more processors, the vehicle to switch from a manual driving mode to the autonomous driving mode. receiving, by one or more processors, a request to operate a vehicle in an autonomous driving mode; in response to receiving the request, accessing protocol data and using the protocol data to assess, by the one or more processors, (i) the status of the vehicle's environment, (ii) the vehicle, and systems of the vehicle, and (iii) a driver of the vehicle; generating, by the one or more processors, a set of tasks based on a plurality of preventative conditions identified from the assessments, wherein a task of the set of tasks includes closing a door, each task of the set of tasks being assigned a priority level; selecting a first task based on the priority levels of the set of tasks; displaying, by the one or more processors on a display of the vehicle, the first task and one or more other tasks of the set of tasks in an ordered sequence; only upon determining that all of the tasks of the set of tasks are completed, allowing, by the one or more processors, the vehicle to switch from a manual driving mode to the autonomous driving mode.
An apparatus for ejecting a fluid, - having a control unit for controlling the apparatus, the control unit being configured to control fluid dose ejection steps, during which a fluid dose is ejected from a fluid reservoir through an ejection channel, - wherein the control unit is further configured to determine a priming time length (T prime), the priming time length (T prime) being the length of time since the last ejection of a fluid volume through the ejection channel, - wherein the control unit is further configured to perform a priming test step (612 - 618) comprising the steps of: - determining whether the priming time length (T prime) is longer than a predefined priming threshold time length (T hreshold), and - if the priming time length (T prime) is longer than the priming threshold time length (T threshold), setting the apparatus into a status in which a further fluid dose ejection step is only allowed after execution of an ejection channel priming step (622 - 628). - having a control unit for controlling the apparatus, the control unit being configured to control fluid dose ejection steps, during which a fluid dose is ejected from a fluid reservoir through an ejection channel, - wherein the control unit is further configured to determine a priming time length (T prime), the priming time length (T prime) being the length of time since the last ejection of a fluid volume through the ejection channel, - wherein the control unit is further configured to perform a priming test step (612 - 618) comprising the steps of: - determining whether the priming time length (T prime) is longer than a predefined priming threshold time length (T hreshold), and - if the priming time length (T prime) is longer than the priming threshold time length (T threshold), setting the apparatus into a status in which a further fluid dose ejection step is only allowed after execution of an ejection channel priming step (622 - 628). - determining whether the priming time length (T prime) is longer than a predefined priming threshold time length (T hreshold), and - if the priming time length (T prime) is longer than the priming threshold time length (T threshold), setting the apparatus into a status in which a further fluid dose ejection step is only allowed after execution of an ejection channel priming step (622 - 628).
A method of dispensing an off-gassing liquid product from a product container, comprising: moving the liquid product through a product line and towards a dispenser; combining the liquid product with a diluting liquid product to create a solution; dispensing the solution; and clearing the product line of unused liquid product to unprime the product line after each dispensement. moving the liquid product through a product line and towards a dispenser; combining the liquid product with a diluting liquid product to create a solution; dispensing the solution; and clearing the product line of unused liquid product to unprime the product line after each dispensement.
A composition comprising nicotine and at least one ion pairing agent comprising lactic acid, wherein the composition has a pH of about pH 7 to pH 11; characterized in that: the composition comprises from about 80% to about 98% by weight of at least one solvent that includes one or more alcohol functional groups; and vaporization and condensation of the composition produces an aerosol wherein at least 85% of the nicotine by weight with respect to the total weight of the composition is in a particulate phase of the aerosol. the composition comprises from about 80% to about 98% by weight of at least one solvent that includes one or more alcohol functional groups; and vaporization and condensation of the composition produces an aerosol wherein at least 85% of the nicotine by weight with respect to the total weight of the composition is in a particulate phase of the aerosol.