A multi-ply adhesive device (10, 110, 410, 610, 710, 810, 910, 910') adapted to be applied to the skin of a patient, the multi-ply adhesive device (10, 110, 410, 610, 710, 810, 910, 910') comprising: a top layer (16, 16', 16", 916), a backing layer (12, 12', 12") and a middle layer (14, 14', 14") between the top (16, 16', 16", 916) and backing layers (12, 12', 12"); the middle layer (14, 14', 14") being comprised of at least one middle ply (14, 14', 14") and having a middle layer top surface and a middle layer bottom surface, said middle layer (14, 14', 14") being more stretchable than the top layer (16, 16', 16"); a middle-ply adhesive applied to substantially the entirety of the middle layer bottom surface to removably adhere the backing layer (12, 12', 12") to the middle layer bottom surface, wherein said middle ply adhesive is preferably a gel adhesive, and preferably a silicone adhesive or a co-adhesive; at least one bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) integral with the device (10, 110, 410, 610, 710, 810, 910, 910'); the bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) comprising an inner edge, defined by a top-middle continuous or perforated cut (50, 54, 76, 186a, 188a, 192a, 194a, 932a, 934a, 942a, 944a) extending through the top (16, 16', 16", 916) and middle layers (14, 14', 14") such that when the at least one bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) is pulled away from the top (16, 16', 16", 916) and middle layers (14, 14', 14"), at least a portion of the backing layer (12, 12', 12") will be removed from the middle layer (14, 14', 14") to expose the adhesive of the middle layer (14, 14', 14"); and at least one top ply tab (62, 162, 932, 934, TS1, TS2) integral with the device (10, 110, 410, 610, 710, 810, 910, 910'); the at least one top ply tab (62, 162, 932, 934, TS1, TS2) comprising an inner edge defined by a bottom-middle continuous or perforated cut (68, 952a, 954a) extending through the backing (12, 12', 12") and middle layers (14, 14', 14") such that when the top ply tab (62, 162, 932, 934, TS1, TS2) is pulled away from the backing (12, 12', 12") and middle layers (14, 14', 14"), at least a portion of the top layer (16, 16', 16", 916) will be removed from the middle layer (14, 14', 14"); wherein said top layer (16, 16', 16", 916) is adhered to said middle layer (14, 14', 14") without adhesive; or wherein said top layer (16, 16', 16", 916) is adhered to said middle layer (14, 14', 14") with a top-layer adhesive which substantially covers a bottom surface of said top layer (16, 16', 16", 916), said top layer adhesive preferably being an acrylate adhesive or a co-adhesive. a top layer (16, 16', 16", 916), a backing layer (12, 12', 12") and a middle layer (14, 14', 14") between the top (16, 16', 16", 916) and backing layers (12, 12', 12"); the middle layer (14, 14', 14") being comprised of at least one middle ply (14, 14', 14") and having a middle layer top surface and a middle layer bottom surface, said middle layer (14, 14', 14") being more stretchable than the top layer (16, 16', 16"); a middle-ply adhesive applied to substantially the entirety of the middle layer bottom surface to removably adhere the backing layer (12, 12', 12") to the middle layer bottom surface, wherein said middle ply adhesive is preferably a gel adhesive, and preferably a silicone adhesive or a co-adhesive; at least one bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) integral with the device (10, 110, 410, 610, 710, 810, 910, 910'); the bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) comprising an inner edge, defined by a top-middle continuous or perforated cut (50, 54, 76, 186a, 188a, 192a, 194a, 932a, 934a, 942a, 944a) extending through the top (16, 16', 16", 916) and middle layers (14, 14', 14") such that when the at least one bottom ply tab (60, 74, 160, 174, 186, 188, 192, 194, 944, 952', 954', BPT1, BPT2) is pulled away from the top (16, 16', 16", 916) and middle layers (14, 14', 14"), at least a portion of the backing layer (12, 12', 12") will be removed from the middle layer (14, 14', 14") to expose the adhesive of the middle layer (14, 14', 14"); and at least one top ply tab (62, 162, 932, 934, TS1, TS2) integral with the device (10, 110, 410, 610, 710, 810, 910, 910'); the at least one top ply tab (62, 162, 932, 934, TS1, TS2) comprising an inner edge defined by a bottom-middle continuous or perforated cut (68, 952a, 954a) extending through the backing (12, 12', 12") and middle layers (14, 14', 14") such that when the top ply tab (62, 162, 932, 934, TS1, TS2) is pulled away from the backing (12, 12', 12") and middle layers (14, 14', 14"), at least a portion of the top layer (16, 16', 16", 916) will be removed from the middle layer (14, 14', 14"); wherein said top layer (16, 16', 16", 916) is adhered to said middle layer (14, 14', 14") without adhesive; or wherein said top layer (16, 16', 16", 916) is adhered to said middle layer (14, 14', 14") with a top-layer adhesive which substantially covers a bottom surface of said top layer (16, 16', 16", 916), said top layer adhesive preferably being an acrylate adhesive or a co-adhesive.