mhurhangee/ep-ind-claims huggingface dataset:
A modified human IgG1 comprising an Fc region comprising amino acid substitutions at two or more of positions 432 to 437, numbered according to the EU numbering index of Kabat, relative to a human wild-type Fc region; wherein (i) positions 432 and 437 are each substituted with cysteine; (ii) position 433 is histidine or is substituted with arginine, proline, threonine, lysine, serine, alanine, methionine, or asparagine; (iii) position 434 is asparagine or is substituted with arginine, tryptophan, histidine, phenylalanine, tyrosine, serine, methionine or threonine; (iv) position 435 is histidine or is substituted with histidine; and (v) position 436 is tyrosine or phenylalanine or is substituted with leucine, arginine, isoleucine, lysine, methionine, valine, histidine, serine, or threonine; and wherein the modified human IgG1 has an increased half-life compared to the half-life of an IgG1 having the human wild-type Fc region. (i) positions 432 and 437 are each substituted with cysteine; (ii) position 433 is histidine or is substituted with arginine, proline, threonine, lysine, serine, alanine, methionine, or asparagine; (iii) position 434 is asparagine or is substituted with arginine, tryptophan, histidine, phenylalanine, tyrosine, serine, methionine or threonine; (iv) position 435 is histidine or is substituted with histidine; and (v) position 436 is tyrosine or phenylalanine or is substituted with leucine, arginine, isoleucine, lysine, methionine, valine, histidine, serine, or threonine; and
A dry grind alcohol production process, the process comprising: grinding dry corn kernels into corn flour; mixing the corn flour with a liquid to form a slurry including free oil, protein, starch, and fiber, germ, and grit particles; subjecting the slurry of step to the start of liquefaction, which includes adding an enzyme to the slurry after step, separating the slurry, via particle sizes alone, into a solids portion, including the fiber, grit, and germ particles, and a liquid portion, including the free oil, protein, and starch of the slurry; milling the separated solids portion of step to reduce the size of the fiber, grit, and germ particles and release starch, oil, and protein therefrom; recombining at least the starch from the separated liquid portion of step with at least the released starch of step to form a second slurry; converting the starches in the second slurry of step to sugar; producing alcohol from the sugar of step via fermentation; and recovering the alcohol after fermentation. grinding dry corn kernels into corn flour; mixing the corn flour with a liquid to form a slurry including free oil, protein, starch, and fiber, germ, and grit particles; subjecting the slurry of step to the start of liquefaction, which includes adding an enzyme to the slurry after step, separating the slurry, via particle sizes alone, into a solids portion, including the fiber, grit, and germ particles, and a liquid portion, including the free oil, protein, and starch of the slurry; milling the separated solids portion of step to reduce the size of the fiber, grit, and germ particles and release starch, oil, and protein therefrom; recombining at least the starch from the separated liquid portion of step with at least the released starch of step to form a second slurry; converting the starches in the second slurry of step to sugar; producing alcohol from the sugar of step via fermentation; and recovering the alcohol after fermentation.
A shovel comprising: a hydraulic actuator; an operating apparatus used to operate the hydraulic actuator; characterised in that the shovel further comprises an obtaining device configured to obtain information concerning a vibration of a body of the shovel; and a control device configured to perform such control as to reduce responsiveness of the hydraulic actuator to an operation of the operating apparatus when the body of the shovel is vibrating or the vibration is likely to occur in the body of the shovel, based on an output of the obtaining device. a hydraulic actuator; an operating apparatus used to operate the hydraulic actuator; characterised in that the shovel further comprises an obtaining device configured to obtain information concerning a vibration of a body of the shovel; and a control device configured to perform such control as to reduce responsiveness of the hydraulic actuator to an operation of the operating apparatus when the body of the shovel is vibrating or the vibration is likely to occur in the body of the shovel, based on an output of the obtaining device.
An electric submersible pump (ESP; 147, 210) comprising: a shaft (506, 606, 706, 806, 906); an electric motor (215, 350) configured to rotatably drive the shaft; a housing (510, 610, 710, 810, 910); a stack of diffusers (540-1 to 540-N, 640-1 to 640-2) disposed in the housing; and impellers (520-1 to 520-N, 620-1 to 620-2) disposed in the housing and operatively coupled to the shaft, wherein the impellers form hydraulic seals with respect to the diffusers; characterised in that a proximity sensor is operatively coupled to the housing, and the proximity sensor is configured as a diffuser sensor that senses axial displacement between at least one pair of adjacent diffusers in the stack of diffusers. a shaft (506, 606, 706, 806, 906); an electric motor (215, 350) configured to rotatably drive the shaft; a housing (510, 610, 710, 810, 910); a stack of diffusers (540-1 to 540-N, 640-1 to 640-2) disposed in the housing; and impellers (520-1 to 520-N, 620-1 to 620-2) disposed in the housing and operatively coupled to the shaft, wherein the impellers form hydraulic seals with respect to the diffusers; characterised in that a proximity sensor is operatively coupled to the housing, and the proximity sensor is configured as a diffuser sensor that senses axial displacement between at least one pair of adjacent diffusers in the stack of diffusers.
A method performed by a user equipment, the user equipment comprising: determining to send a hypertext transfer protocol authentication message from the user equipment of a user to a merchant node of a merchant; the determining to send the hypertext transfer protocol authentication message further comprises determining to send the hypertext transfer protocol authentication message in response to a buy response message that indicates a short message service address for the merchant node and text to identify a transaction; if the user is not authenticated in response to the hypertext transfer protocol authentication message, then determining to send, from the user equipment to the merchant node, a short message service message that indicates the transaction between the merchant and the user, wherein: the short message service message is directed to the short message service address for the merchant and includes the text to identify the transaction. determining to send a hypertext transfer protocol authentication message from the user equipment of a user to a merchant node of a merchant; the determining to send the hypertext transfer protocol authentication message further comprises determining to send the hypertext transfer protocol authentication message in response to a buy response message that indicates a short message service address for the merchant node and text to identify a transaction; if the user is not authenticated in response to the hypertext transfer protocol authentication message, then determining to send, from the user equipment to the merchant node, a short message service message that indicates the transaction between the merchant and the user, wherein: the short message service message is directed to the short message service address for the merchant and includes the text to identify the transaction.
A method of coating a substrate comprising: to an assembly comprising a substrate, a porous matrix on the substrate, and an impregnating material on the porous matrix, wherein the porous matrix is in the form of a filter, a sponge, a honeycomb or a foam material, applying an amount of energy from an energy source effective to melt the impregnating material and a portion of the substrate such that the impregnating material impregnates the porous matrix; and cooling the assembly to provide a coating (26, 26A) comprising the impregnated porous matrix integrated with the substrate. wherein the porous matrix comprises a material having a higher melting temperature than that of the impregnating material. to an assembly comprising a substrate, a porous matrix on the substrate, and an impregnating material on the porous matrix, wherein the porous matrix is in the form of a filter, a sponge, a honeycomb or a foam material, applying an amount of energy from an energy source effective to melt the impregnating material and a portion of the substrate such that the impregnating material impregnates the porous matrix; and cooling the assembly to provide a coating (26, 26A) comprising the impregnated porous matrix integrated with the substrate. wherein the porous matrix comprises a material having a higher melting temperature than that of the impregnating material.
Acetyl-leucine, or a pharmaceutically acceptable salt thereof, for use in treating Niemann-Pick type C disease or one or more symptoms associated with Niemann-Pick type C disease in a subject in need thereof, wherein the use comprises administering a therapeutically effective amount of the acetyl-leucine to the subject in need thereof for a duration chosen from at least about 6 months, at least about 1 year, at least about 2 years, and at least about 5 years.
Composite construction, consisting - of a glazing unit, - a post-and-beam structure, - a coupling component, which is mounted on the post-and-beam structure, and at least one fixing element, which is mounted between the coupling component and the glazing unit, - wherein the glazing unit is introduced into a region between two posts and at least one beam, characterized in that the fixing element has a basic body and an adjusting element (41; 42) and the position of the adjusting element (41; 42) is adjustable in relation to the basic body and is able to be fixed in a plurality of positions in relation to the basic body, wherein the fixing element is clamped in between the coupling component and the glazing unit by means of a movement of the adjusting element (41; 42) away from the basic body. - of a glazing unit, - a post-and-beam structure, - a coupling component, which is mounted on the post-and-beam structure, and at least one fixing element, which is mounted between the coupling component and the glazing unit, - wherein the glazing unit is introduced into a region between two posts and at least one beam,
A patient side cart for a teleoperated surgical system, comprising: a base; a main column; and an arm (110, 520, 620) connected to the main column, the arm comprising a mount (124, 522) and an array of sensors (622, 900); wherein the mount (124, 522) is configured to support a cannula (300, 400, 500, 700, 1600) in a mounted position on the arm; and wherein each sensor (920 to 923, 1010 to 1040, 1210 to 1230, 1310 to 1320, 1410) of the array of sensors is configured to sense a presence, a polarity, and an orientation of a magnet (714, 820 to 823) of one or more magnets positioned at a corresponding position (810 to 813, 1614) of an array of magnet positions (800, 1612) at a cannula supported in the mounted position on the arm so as to receive information associated with the cannula. a base; a main column; and an arm (110, 520, 620) connected to the main column, the arm comprising a mount (124, 522) and an array of sensors (622, 900); wherein the mount (124, 522) is configured to support a cannula (300, 400, 500, 700, 1600) in a mounted position on the arm; and wherein each sensor (920 to 923, 1010 to 1040, 1210 to 1230, 1310 to 1320, 1410) of the array of sensors is configured to sense a presence, a polarity, and an orientation of a magnet (714, 820 to 823) of one or more magnets positioned at a corresponding position (810 to 813, 1614) of an array of magnet positions (800, 1612) at a cannula supported in the mounted position on the arm so as to receive information associated with the cannula.
Method for producing suspension strut forks for motor vehicles, wherein a suspension strut fork has a suspension strut receptacle and fork arms (3, 4) and is produced from a metallic extruded profile which has a central, middle main chamber with longitudinal chambers (11, 12) on the outside, characterised by the following steps: - providing an extruded profile with at least four longitudinal chambers (11, 12) which are arranged offset with respect to one another over the circumference of the main chamber; - removing wall portions of the main chamber which are situated between the longitudinal chambers (11, 12), and separating the extruded profile into two semi-finished parts, which each have a cylinder portion and two oppositely situated arm portions (11', 12') which project relative to the cylinder portion; - mechanically machining the semi-finished parts to form in each case one suspension strut fork. - providing an extruded profile with at least four longitudinal chambers (11, 12) which are arranged offset with respect to one another over the circumference of the main chamber; - removing wall portions of the main chamber which are situated between the longitudinal chambers (11, 12), and separating the extruded profile into two semi-finished parts, which each have a cylinder portion and two oppositely situated arm portions (11', 12') which project relative to the cylinder portion; - mechanically machining the semi-finished parts to form in each case one suspension strut fork.
A device for deterring or repelling a member of given animal species from a tunnel of a subterranean tunnel system, which device comprises a housing (1a, 1b) having a first housing portion defining a chamber containing an acoustic generator and a second housing portion defining a passage acoustically coupled to the acoustic generator, the second housing portion being configured to form part of a tunnel of the subterranean tunnel system so that a member of the animal species can pass along the passage and the acoustic generator being arranged to emit an acoustic signal into the passage and so into the tunnel to deter or repel member of that animal species from at least that tunnel of the subterranean tunnel system, characterized in that the passage is defined by a hollow arr acoustic tube of the second housing portion, the acoustic tube being configured to extend along a part of the tunnel of the subterranean tunnel system.
Method for determining the concentrations of lipids and at least one further substance in a body fluid sample, comprising the steps of: a) irradiating light through the body fluid sample at a multiplicity of wavelengths and b) capturing a multiplicity of measured values of the absorbance of the body fluid sample at the multiplicity of wavelengths; characterized by the steps of: c) capturing a first measured value at a first wavelength at which the absorbance not caused by lipids is negligible, and determining the concentration (c L) of the lipids by dividing the measured value by the extinction coefficient specific for lipids; d) calculating a power-function approximation curve (L 0) of the form E λ = p ⋅ λ − q for the absorbance of the lipids on the basis of the first measured value by determining the factor p at predetermined exponent q; e) determining a first approximate value (C H) of the concentration of the second substance on the basis of a second measured value and values of the approximation curve (L 0) at a second wavelength. a) irradiating light through the body fluid sample at a multiplicity of wavelengths and b) capturing a multiplicity of measured values of the absorbance of the body fluid sample at the multiplicity of wavelengths; c) capturing a first measured value at a first wavelength at which the absorbance not caused by lipids is negligible, and determining the concentration (c L) of the lipids by dividing the measured value by the extinction coefficient specific for lipids; d) calculating a power-function approximation curve (L 0) of the form E λ = p ⋅ λ − q for the absorbance of the lipids on the basis of the first measured value by determining the factor p at predetermined exponent q; e) determining a first approximate value (C H) of the concentration of the second substance on the basis of a second measured value and values of the approximation curve (L 0) at a second wavelength.
Lining sleeve for rehabilitating fluid-conducting line systems, having at least one curable layer composed of at least one resin-impregnated fibre band and having a first outer film sleeve which is arranged on the curable layer on the side facing away from the flowing medium and both sides of which are provided with a reinforcement having a thickness of 10 to 1000 μm, wherein both sides of said outer film sleeve are impregnated with resin.
A method comprising: receiving, by a receiver, radar return data, wherein the radar return data is associated with reflections, from a scene, of a plurality of transmitted radar signals; processing the radar return data using each of a plurality of different processing sizes to obtain a plurality of sets of detection data (460, 465, 470), wherein each processing size is associated with processing of a respective amount of the radar return data, and wherein each set of detection data of the plurality of sets of detection data is associated with a different processing size from the other sets of detection data; and generating target data associated with the scene based at least in part on the plurality of sets of detection data. receiving, by a receiver, radar return data, wherein the radar return data is associated with reflections, from a scene, of a plurality of transmitted radar signals; processing the radar return data using each of a plurality of different processing sizes to obtain a plurality of sets of detection data (460, 465, 470), wherein each processing size is associated with processing of a respective amount of the radar return data, and wherein each set of detection data of the plurality of sets of detection data is associated with a different processing size from the other sets of detection data; and generating target data associated with the scene based at least in part on the plurality of sets of detection data.
A method of a User Equipment, UE, the method comprising: at least one of receiving or detecting a first Physical Downlink Control Channel, PDCCH, of a transmission of data from a network, wherein the transmission of the data is addressed to a Group Radio Network Temporary Identifier, G-RNTI, for a Hybrid Automatic Repeat Request, HARQ, process; in response to at least one of receiving or detecting the first PDCCH of the transmission of the data: starting a multicast HARQ Round Trip Time, RTT, timer for the HARQ process; and starting a unicast HARQ RTT timer for the HARQ process; in response to expiry of the multicast HARQ RTT timer, starting a multicast retransmission timer for the HARQ process; in response to expiry of the unicast HARQ RTT timer, starting a unicast retransmission timer for the HARQ process; at least one of receiving or detecting a second PDCCH of a first retransmission of the data addressed to the G-RNTI for the HARQ process; and in response to at least one of receiving or detecting the second PDCCH of the first retransmission of the data: stopping the multicast retransmission timer; and stopping the unicast retransmission timer. at least one of receiving or detecting a first Physical Downlink Control Channel, PDCCH, of a transmission of data from a network, wherein the transmission of the data is addressed to a Group Radio Network Temporary Identifier, G-RNTI, for a Hybrid Automatic Repeat Request, HARQ, process; in response to at least one of receiving or detecting the first PDCCH of the transmission of the data: starting a multicast HARQ Round Trip Time, RTT, timer for the HARQ process; and starting a unicast HARQ RTT timer for the HARQ process; starting a multicast HARQ Round Trip Time, RTT, timer for the HARQ process; and starting a unicast HARQ RTT timer for the HARQ process; in response to expiry of the multicast HARQ RTT timer, starting a multicast retransmission timer for the HARQ process; in response to expiry of the unicast HARQ RTT timer, starting a unicast retransmission timer for the HARQ process; at least one of receiving or detecting a second PDCCH of a first retransmission of the data addressed to the G-RNTI for the HARQ process; and in response to at least one of receiving or detecting the second PDCCH of the first retransmission of the data: stopping the multicast retransmission timer; and stopping the unicast retransmission timer. stopping the multicast retransmission timer; and stopping the unicast retransmission timer.
A device for processing flexible, band-shaped substrates, wherein the device has a compartment for processing the flexible substrate, an unwinder and a rewinder for the flexible substrate that are arranged outside of the compartment, as well as means for guiding the flexible substrate from the unwinder to the rewinder, wherein the compartment has at least one sealed bushing for guiding the flexible substrate into the compartment and/or from the compartment, characterized in that the compartment has a main region and at least one channel-shaped transition region (4, 5) the extension (x 1) of which in at least one direction, the reference direction, is smaller than the extension (x 3) of the main region in the same direction, and that the unwinder and the rewinder are attached to the outer wall of the compartment, wherein the device has no winder casing with intermediate compartments or separate vacuum compartments that can be separated from a coil located in the unwinder or rewinder and in which temperature and/or pressure conditions can be generated that differ from the space in which the respective coil is located.
Antiballistic protection comprising a cover with a stab and bullet resistant layer, and in which said antiballistic protection comprises a central chest section and at least two wing sections (12, 13), whereby said stab and bullet resistant layer is composed of a stab resistant layer of polyamide and a bullet resistant layer of ultra-high molecular weight polyethylene, wherein said stab resistant layer is composed of a plurality of polyamide textile layers in which at least one polyamide textile layer has a surface weight lower than 200 g/m 2, characterized in that said bullet resistant layer is composed of a plurality of 10 to 100 ultra-high molecular weight polyethylene laminates with a surface weight of 70 to 90 g/m 2.