A compound or a pharmaceutically acceptable salt or isotopic variant thereof having the structure: R 1, R 2, R 3, R 4, and R 5 are each independently H, halogen, CF 3 or C 1 -C 4 alkyl; R 6 is H, OH, or halogen; B has the structure: wherein n is 1; R 7 is H, C 1 -C 4 alkyl, or oxetane; Y 1 and Y 4 are each independently CH 2 or C(CH 3) 2; one of Y 2 or Y 3 is CH 2 and the other of Y 2 or Y 3 is O, SO 2, or N-R 10; R 10 is H, C 1 -C 10 alkyl, C 3 -C 6 cycloalkyl, (C 1 -C 10 alkyl)-CF 3, (C 1 -C 10 alkyl)-OCH 3, (C 1 -C 10 alkyl)-halogen, SO 2 -(C 1 -C 10 alkyl), SO 2 -(C 1 -C 10 alkyl)-CF 3, SO 2 -(C 1 -C 10 alkyl)-OCH 3, SO 2 -(C 1 -C 10 alkyl)-halogen, C -(C 1 -C 10 alkyl), C -(C 1 -C 10 alkyl)-CF 3, C -(C 1 -C 10 alkyl)-OCH 3, C -(C 1 -C 10 alkyl)- halogen, C -NH-(C 1 -C 10 alkyl), C -N(C 1 -C 10 alkyl) 2, C 1 -C 10 alkyl)-C OH, or oxetane; or B has the structure: wherein Y 1, Y 2, Y 3 and Y 4 are each independently CR 8 or N, and each R 8 is independently H, halogen, C 1 -C 4 alkyl, C 1 -C 4 cycloalkyl, O-(C 1 -C 4 alkyl), C OH, C -NH 2, C -N(CH 3) 2, C - NHCH 3, NHC -N(CH 3) 2, CN, or CF 3, wherein each occurrence of alkyl is substituted or unsubstituted and when substituted is substituted with a halogen, alkoxy, alkylthio, trifluoromethyl, difluoromethyl, methoxy, hydroxyl, mercapto, amino, carboxy, cyano or carbamoyl. R 1, R 2, R 3, R 4, and R 5 are each independently H, halogen, CF 3 or C 1 -C 4 alkyl; R 6 is H, OH, or halogen; B has the structure: wherein n is 1; R 7 is H, C 1 -C 4 alkyl, or oxetane; Y 1 and Y 4 are each independently CH 2 or C(CH 3) 2; one of Y 2 or Y 3 is CH 2 and the other of Y 2 or Y 3 is O, SO 2, or N-R 10; R 10 is H, C 1 -C 10 alkyl, C 3 -C 6 cycloalkyl, (C 1 -C 10 alkyl)-CF 3, (C 1 -C 10 alkyl)-OCH 3, (C 1 -C 10 alkyl)-halogen, SO 2 -(C 1 -C 10 alkyl), SO 2 -(C 1 -C 10 alkyl)-CF 3, SO 2 -(C 1 -C 10 alkyl)-OCH 3, SO 2 -(C 1 -C 10 alkyl)-halogen, C -(C 1 -C 10 alkyl), C -(C 1 -C 10 alkyl)-CF 3, C -(C 1 -C 10 alkyl)-OCH 3, C -(C 1 -C 10 alkyl)- halogen, C -NH-(C 1 -C 10 alkyl), C -N(C 1 -C 10 alkyl) 2, C 1 -C 10 alkyl)-C OH, or oxetane; or B has the structure: wherein Y 1, Y 2, Y 3 and Y 4 are each independently CR 8 or N, and each R 8 is independently H, halogen, C 1 -C 4 alkyl, C 1 -C 4 cycloalkyl, O-(C 1 -C 4 alkyl), C OH, C -NH 2, C -N(CH 3) 2, C - NHCH 3, NHC -N(CH 3) 2, CN, or CF 3, wherein each occurrence of alkyl is substituted or unsubstituted and when substituted is substituted with a halogen, alkoxy, alkylthio, trifluoromethyl, difluoromethyl, methoxy, hydroxyl, mercapto, amino, carboxy, cyano or carbamoyl. n is 1; R 7 is H, C 1 -C 4 alkyl, or oxetane; Y 1 and Y 4 are each independently CH 2 or C(CH 3) 2; one of Y 2 or Y 3 is CH 2 and the other of Y 2 or Y 3 is O, SO 2, or N-R 10; R 10 is H, C 1 -C 10 alkyl, C 3 -C 6 cycloalkyl, (C 1 -C 10 alkyl)-CF 3, (C 1 -C 10 alkyl)-OCH 3, (C 1 -C 10 alkyl)-halogen, SO 2 -(C 1 -C 10 alkyl), SO 2 -(C 1 -C 10 alkyl)-CF 3, SO 2 -(C 1 -C 10 alkyl)-OCH 3, SO 2 -(C 1 -C 10 alkyl)-halogen, C -(C 1 -C 10 alkyl), C -(C 1 -C 10 alkyl)-CF 3, C -(C 1 -C 10 alkyl)-OCH 3, C -(C 1 -C 10 alkyl)- halogen, C -NH-(C 1 -C 10 alkyl), C -N(C 1 -C 10 alkyl) 2, C 1 -C 10 alkyl)-C OH, or oxetane; or B has the structure: wherein Y 1, Y 2, Y 3 and Y 4 are each independently CR 8 or N, and each R 8 is independently H, halogen, C 1 -C 4 alkyl, C 1 -C 4 cycloalkyl, O-(C 1 -C 4 alkyl), C OH, C -NH 2, C -N(CH 3) 2, C - NHCH 3, NHC -N(CH 3) 2, CN, or CF 3, wherein each occurrence of alkyl is substituted or unsubstituted and when substituted is substituted with a halogen, alkoxy, alkylthio, trifluoromethyl, difluoromethyl, methoxy, hydroxyl, mercapto, amino, carboxy, cyano or carbamoyl. Y 1, Y 2, Y 3 and Y 4 are each independently CR 8 or N, and each R 8 is independently H, halogen, C 1 -C 4 alkyl, C 1 -C 4 cycloalkyl, O-(C 1 -C 4 alkyl), C OH, C -NH 2, C -N(CH 3) 2, C - NHCH 3, NHC -N(CH 3) 2, CN, or CF 3, wherein each occurrence of alkyl is substituted or unsubstituted and when substituted is substituted with a halogen, alkoxy, alkylthio, trifluoromethyl, difluoromethyl, methoxy, hydroxyl, mercapto, amino, carboxy, cyano or carbamoyl.