A guiding device for positioning and guiding an injection device for intradermal injection of a dosage to a subject, said injection device comprising a syringe body having a predetermined profile at a distal end thereof and a needle having a distal needle end adapted to penetrate a skin surface of the subject for intradermal injection of the dosage; said guiding device comprising: a base having a contact surface for alignment with the skin surface of the subject, and a tubular guiding device configured for guiding an axial movement of the injection device toward the skin surface from a retracted first state where the distal needle end does not penetrate the skin surface and is shielded against the skin surface by a portion of the guiding device to a second state where the distal needle end penetrates the skin surface of the subject, said tubular guiding device defining a central axis slanted relative to the contact surface at an acute angle (α) and comprising a distal opening to be passed by the distal needle end for intradermal injection, wherein the contact surface of the base is planar and the tubular guiding device is slanted relative to the base at said acute angle (α), wherein the tubular guiding device comprises a sleeve-shaped guiding portion (32, 33) that tightly matches the predetermined profile at the distal end of the injection device, for preventing a tilting of the injection device about the central axis at or near the foremost distal position of the injection device in the tubular guiding device, and the tubular guiding device comprises at least one locking member provided at a side proximal to the sleeve-shaped guiding portion (32, 33) and configured for locking the injection device to the guiding device in the foremost distal position of the injection device in the tubular guiding device and coupling the injection device to the guiding device in the second state of the injection device, characterized in that the at least one locking member is a positive-fit locking member configured for locking the injection device to the guiding device in the foremost distal position of the injection device in the tubular guiding device in a positive-fit manner and coupling the injection device to the guiding device in the second state of the injection device such that the injection device can be removed from the skin surface after injection of the dosage to the subject together with the guiding device while being coupled to the tubular guiding device. a base having a contact surface for alignment with the skin surface of the subject, and a tubular guiding device configured for guiding an axial movement of the injection device toward the skin surface from a retracted first state where the distal needle end does not penetrate the skin surface and is shielded against the skin surface by a portion of the guiding device to a second state where the distal needle end penetrates the skin surface of the subject, said tubular guiding device defining a central axis slanted relative to the contact surface at an acute angle (α) and comprising a distal opening to be passed by the distal needle end for intradermal injection, wherein the contact surface of the base is planar and the tubular guiding device is slanted relative to the base at said acute angle (α), wherein the tubular guiding device comprises a sleeve-shaped guiding portion (32, 33) that tightly matches the predetermined profile at the distal end of the injection device, for preventing a tilting of the injection device about the central axis at or near the foremost distal position of the injection device in the tubular guiding device, and the tubular guiding device comprises at least one locking member provided at a side proximal to the sleeve-shaped guiding portion (32, 33) and configured for locking the injection device to the guiding device in the foremost distal position of the injection device in the tubular guiding device and coupling the injection device to the guiding device in the second state of the injection device, the tubular guiding device comprises a sleeve-shaped guiding portion (32, 33) that tightly matches the predetermined profile at the distal end of the injection device, for preventing a tilting of the injection device about the central axis at or near the foremost distal position of the injection device in the tubular guiding device, and the tubular guiding device comprises at least one locking member provided at a side proximal to the sleeve-shaped guiding portion (32, 33) and configured for locking the injection device to the guiding device in the foremost distal position of the injection device in the tubular guiding device and coupling the injection device to the guiding device in the second state of the injection device, characterized in that the at least one locking member is a positive-fit locking member configured for locking the injection device to the guiding device in the foremost distal position of the injection device in the tubular guiding device in a positive-fit manner and coupling the injection device to the guiding device in the second state of the injection device such that the injection device can be removed from the skin surface after injection of the dosage to the subject together with the guiding device while being coupled to the tubular guiding device.