mhurhangee/ep-ind-claims huggingface dataset:
A lipidoid nanoparticle for use in treating a human lipoprotein metabolism disorder or a cardiovascular disease, wherein the lipidoid nanoparticle comprises a lipid, a CRISPR/Cas9 mRNA, and a single guide RNA (sgRNA), wherein the sgRNA is single guide Angiopoietin-like 3 (sgANGPTL3) or single guide proprotein convertase subtilisin/kexin type 9 (sgPCSK9); wherein the lipid is represented by formula I: R Head -R Lipid, or a pharmaceutically acceptable salt thereof, wherein R Head is R a and R a ' are each independently R Lipid; Z is a C 1 -C 20 bivalent aliphatic radical, a C 1 -C 20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; and R Lipid each independently is wherein: R 1 and R 2 are H, OH, NHR 30, or SH; R 3 and R 4 are taken together to form an oxo (=O) group; X is CH 2, O, NR 30, or S; R 30 is H, C 1-6 alkyl, C 1-6 alkenyl, or C 1-6 alkynyl; m is an integer selected from 1-3; n is an integer selected from 1-14; p is 0 or 1; q is an integer selected from 1-10; and t is 0, 1, or 2. the sgRNA is single guide Angiopoietin-like 3 (sgANGPTL3) or single guide proprotein convertase subtilisin/kexin type 9 (sgPCSK9); wherein the lipid is represented by formula I: R Head -R Lipid, or a pharmaceutically acceptable salt thereof, wherein R Head is R a and R a ' are each independently R Lipid; Z is a C 1 -C 20 bivalent aliphatic radical, a C 1 -C 20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; and R Lipid each independently is wherein: R 1 and R 2 are H, OH, NHR 30, or SH; R 3 and R 4 are taken together to form an oxo (=O) group; X is CH 2, O, NR 30, or S; R 30 is H, C 1-6 alkyl, C 1-6 alkenyl, or C 1-6 alkynyl; m is an integer selected from 1-3; n is an integer selected from 1-14; p is 0 or 1; q is an integer selected from 1-10; and t is 0, 1, or 2. R Head is R a and R a ' are each independently R Lipid; Z is a C 1 -C 20 bivalent aliphatic radical, a C 1 -C 20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; and R Lipid each independently is wherein: R 1 and R 2 are H, OH, NHR 30, or SH; R 3 and R 4 are taken together to form an oxo (=O) group; X is CH 2, O, NR 30, or S; R 30 is H, C 1-6 alkyl, C 1-6 alkenyl, or C 1-6 alkynyl; m is an integer selected from 1-3; n is an integer selected from 1-14; p is 0 or 1; q is an integer selected from 1-10; and t is 0, 1, or 2. R 1 and R 2 are H, OH, NHR 30, or SH; R 3 and R 4 are taken together to form an oxo (=O) group; X is CH 2, O, NR 30, or S; R 30 is H, C 1-6 alkyl, C 1-6 alkenyl, or C 1-6 alkynyl; m is an integer selected from 1-3; n is an integer selected from 1-14; p is 0 or 1; q is an integer selected from 1-10; and t is 0, 1, or 2.
A frozen food product comprising a bakery product substrate, a sweetened edible coating on the bakery product substrate comprising a frosting, icing or glaze, and a gloss-enhancing coating on the sweetened edible coating, the gloss-enhancing coating being edible and ethanol soluble, and consisting essentially of shellac, zein or a mixture thereof and one or more adjuncts selected from the group consisting of medium chain triglycerides, vegetable oils, acetylated monoglycerides, propylene glycol and polyethylene glycol, the gloss-enhancing coating being applied before the frozen food product is frozen, wherein in use, the gloss-enhancing coating substantially reduces loss of surface gloss after freezing and thawing that would otherwise occur in the absence of the gloss-enhancing coating.
A drain valve button bracket with a directed push button, comprising: a bracket, for being arranged on a drain valve in a circumferential limiting manner, that is in a manner limiting rotation in the circumferential direction; a push button main body, having an accommodating cavity and in threaded connection with the bracket; a push button component, slidably arranged in the accommodating cavity and rotatable relative to the push button main body; a compression bar, arranged on the bracket in the circumferential limiting manner, in circumferential limiting fit with the push button component; characterized by further comprising a connecting sleeve, an upper part of which is arranged in the push button main body in an axially movable manner, capable of rotating with the push button main body and rotatably connected with the push button component; and in that the compression bar, is in threaded connection with the connecting sleeve; and in that the connecting sleeve is configured to drive the compression bar to move along the axial direction so as to be capable of driving the drain valve to open to drain water, when the push button component is operated. a bracket, for being arranged on a drain valve in a circumferential limiting manner, that is in a manner limiting rotation in the circumferential direction; a push button main body, having an accommodating cavity and in threaded connection with the bracket; a push button component, slidably arranged in the accommodating cavity and rotatable relative to the push button main body; a compression bar, arranged on the bracket in the circumferential limiting manner, in circumferential limiting fit with the push button component; characterized by further comprising a connecting sleeve, an upper part of which is arranged in the push button main body in an axially movable manner, capable of rotating with the push button main body and rotatably connected with the push button component; and in that the compression bar, is in threaded connection with the connecting sleeve; and in that the connecting sleeve is configured to drive the compression bar to move along the axial direction so as to be capable of driving the drain valve to open to drain water, when the push button component is operated.
A laminate sleeve for use in covering a pipe joint, comprising: a. an inner adhesive layer; b. an outer layer comprising a cross-linked polyolefin; c. an intermediate layer, between said inner layer and said outer layer, and bonded thereto, comprising a heat sensitive polymeric compound, wherein the inner layer is thinner than the intermediate layer. a. an inner adhesive layer; b. an outer layer comprising a cross-linked polyolefin; c. an intermediate layer, between said inner layer and said outer layer, and bonded thereto, comprising a heat sensitive polymeric compound, wherein the inner layer is thinner than the intermediate layer.
A sputtering target assembly for a sputtering chamber, comprising: at least one first sputtering target (102A, 102B), the first sputtering target being cylindrical and including a longitudinal axis about which the first target rotates; and at least one second sputtering target (103A, 103B), the second sputtering target being cylindrical and including a longitudinal axis about which the second target rotates; characterized in that: the assembly further comprises a lid (120, 324, 326) to seal off an opening to the chamber; the at least one first target and the at least one second target are mounted to the lid for placement within the chamber, when the lid seals off the opening; and the at least one second sputtering target is spaced apart from the at least one first sputtering target at a distance allowing conveyance of a substrate therebetween, when the lid seals off the opening, the lid includes a first part and a second part, the first part being separable from the second part, wherein the at least one first target is mounted to the first part; and the at least one second target is mounted to the second part. at least one first sputtering target (102A, 102B), the first sputtering target being cylindrical and including a longitudinal axis about which the first target rotates; and at least one second sputtering target (103A, 103B), the second sputtering target being cylindrical and including a longitudinal axis about which the second target rotates; characterized in that: the assembly further comprises a lid (120, 324, 326) to seal off an opening to the chamber; the at least one first target and the at least one second target are mounted to the lid for placement within the chamber, when the lid seals off the opening; and the at least one second sputtering target is spaced apart from the at least one first sputtering target at a distance allowing conveyance of a substrate therebetween, when the lid seals off the opening, the assembly further comprises a lid (120, 324, 326) to seal off an opening to the chamber; the at least one first target and the at least one second target are mounted to the lid for placement within the chamber, when the lid seals off the opening; and the at least one second sputtering target is spaced apart from the at least one first sputtering target at a distance allowing conveyance of a substrate therebetween, when the lid seals off the opening, the lid includes a first part and a second part, the first part being separable from the second part, wherein the at least one first target is mounted to the first part; and the at least one second target is mounted to the second part.
A method for intermittently cleaning a filter in a filter device, which filter device comprises a filter housing and the filter located therein, wherein the filter housing has a medium inlet and a medium outlet for a medium to be filtered, wherein furthermore the medium flowing through the medium inlet passes through the filter during filter operation and exits the filter device via the medium outlet, wherein furthermore for cleaning the filter both the medium inlet and the medium outlet are closed, thereafter a negative pressure is produced in the filter housing and, with the aid of the negative pressure, a flushing medium which acts upon the filter for cleaning is sucked into the filter housing, wherein further the filter device has a filtered material collecting chamber, characterized in that before sucking the flushing medium into the filter housing, the filtered material collecting chamber is closed in order to maintain the negative pressure in the filtered material collecting chamber.
Heat exchanger for a refrigerant fluid loop, the heat exchanger comprising at least one inlet configured to allow a refrigerant fluid to enter in the heat exchanger, at least one outlet configured to allow the refrigerant fluid to exit the heat exchanger, and an integrated receiver drier comprising filtering means located therein, the heat exchanger comprising a filter configured to filter the refrigerant fluid, characterized in that the filter is arranged at the outlet of the heat exchanger, wherein the filter is separated from any filtering means located in the integrated receiver drier.
An antenna array comprising an array of antenna bodies (121, 122) arranged on a planar structure, the planar structure comprising a circuit board and a ground-plane layer (220, 320, 420, 520, 620, 720, 820), the array of antenna bodies (121, 122) being arranged on a top side of the circuit board, each of said antenna bodies (121, 122) comprising a dome shaped structure which is attached to said top side of the circuit board along a base of the dome shaped structure, each of said antenna bodies (121, 122) being connected to a respective top transmission line (350, 450, 550, 650, 750, 850) configured to convey microwave signals to and/or from said antenna bodies (121, 122), the top transmission lines (350, 450, 550, 650, 750, 850) being further connected to bottom transmission lines (330, 430, 530, 630, 730) via coaxial probes (340, 440, 540, 640, 740, 840) through said ground-plane layer (220, 320, 420, 520, 620, 720, 820), and a resonance cavity (260, 360, 460, 560, 660, 760, 860) being arranged below a bottom side of the circuit board between each of said antenna bodies (121, 122). the planar structure comprising a circuit board and a ground-plane layer (220, 320, 420, 520, 620, 720, 820), the array of antenna bodies (121, 122) being arranged on a top side of the circuit board, each of said antenna bodies (121, 122) comprising a dome shaped structure which is attached to said top side of the circuit board along a base of the dome shaped structure, each of said antenna bodies (121, 122) being connected to a respective top transmission line (350, 450, 550, 650, 750, 850) configured to convey microwave signals to and/or from said antenna bodies (121, 122), the top transmission lines (350, 450, 550, 650, 750, 850) being further connected to bottom transmission lines (330, 430, 530, 630, 730) via coaxial probes (340, 440, 540, 640, 740, 840) through said ground-plane layer (220, 320, 420, 520, 620, 720, 820), and a resonance cavity (260, 360, 460, 560, 660, 760, 860) being arranged below a bottom side of the circuit board between each of said antenna bodies (121, 122).
A bed or chair exit sensing device to be placed in, on or in relation to a bed or chair, and adapted to detect a person leaving the bed or chair, comprising a piezoelectric sensor and a data processing device adapted to determine, by processing the signals from the piezoelectric sensor, when the person is leaving the bed or chair, wherein the sensing device comprises an accelerometer sensor, and said data processing device is adapted to determine bed or chair exit of a person on the basis of combined processing of the signal from said piezoelectric sensor and the signal from said accelerometer sensor, wherein bed or chair exit of a person is determined if a condition of the signal from the piezoelectric sensor and a condition of the signal from the accelerometer sensor are fulfilled, characterized in that a first one of said conditions is monitored, and if said first condition is fulfilled, sampling values from the other sensor (30; 34) is started in order to determine whether a corresponding second condition is fulfilled, wherein the bed or chair exit sensing device is fully battery powered, and the piezoelectric sensor, the data processing device and the accelerometer sensor are arranged inside the same housing of the sensing device.
A modular portable intra-aortic balloon pump, comprising: (a) a wheeled cart, and (b) a wheeled pump unit removably mounted on or in the cart, the wheeled pump unit comprising a frame, a pump disposed within the frame, a control unit (250, 252) configured to control the pump, a display device in electronic communication with the wheeled pump unit, and a wheel assembly connected to the frame, the cart including a first power source used to power the pump unit when the pump unit is mounted on or in the cart, the pump unit comprising a second power source used to power the pump unit when the pump unit is removed from the cart or when the pump unit is on or in the cart but the first power source is not functional. (a) a wheeled cart, and (b) a wheeled pump unit removably mounted on or in the cart, the wheeled pump unit comprising a frame, a pump disposed within the frame, a control unit (250, 252) configured to control the pump, a display device in electronic communication with the wheeled pump unit, and a wheel assembly connected to the frame, the cart including a first power source used to power the pump unit when the pump unit is mounted on or in the cart, the pump unit comprising a second power source used to power the pump unit when the pump unit is removed from the cart or when the pump unit is on or in the cart but the first power source is not functional.
An apparatus for testing a secondary battery, comprising: a test path; test terminals provided at two ends of the test path, wherein the test terminals are electrically connected to a positive terminal and a negative terminal (11, 12) of the secondary battery respectively; a sensor unit provided on the test path, wherein the sensor unit is configured to measure a discharge current of the secondary battery; a constant voltage generation unit provided on the test path, wherein the constant voltage generation unit is configured to maintain a constant voltage between the secondary battery and the sensor unit; a memory unit configured to store a referenced value associated with the intensity of the discharge current; and a control unit configured to: receive data indicating the discharge current from the sensor unit, measure an inflection point on a profile of the discharge current, wherein the inflection point is a point where the discharge current is zero, measure an intensity of the discharge current on the basis of the inflection point, and test a level of self-discharge of the secondary battery based on the intensity of the discharge current by determining whether the secondary battery is faulty based on the reference value received form the memory unit. a test path; test terminals provided at two ends of the test path, wherein the test terminals are electrically connected to a positive terminal and a negative terminal (11, 12) of the secondary battery respectively; a sensor unit provided on the test path, wherein the sensor unit is configured to measure a discharge current of the secondary battery; a constant voltage generation unit provided on the test path, wherein the constant voltage generation unit is configured to maintain a constant voltage between the secondary battery and the sensor unit; a memory unit configured to store a referenced value associated with the intensity of the discharge current; and a control unit configured to: receive data indicating the discharge current from the sensor unit, measure an inflection point on a profile of the discharge current, wherein the inflection point is a point where the discharge current is zero, measure an intensity of the discharge current on the basis of the inflection point, and test a level of self-discharge of the secondary battery based on the intensity of the discharge current by determining whether the secondary battery is faulty based on the reference value received form the memory unit. receive data indicating the discharge current from the sensor unit, measure an inflection point on a profile of the discharge current, wherein the inflection point is a point where the discharge current is zero, measure an intensity of the discharge current on the basis of the inflection point, and test a level of self-discharge of the secondary battery based on the intensity of the discharge current by determining whether the secondary battery is faulty based on the reference value received form the memory unit.
A mobile station configured to perform carrier aggregation through a primary cell and a secondary cell, the mobile station comprising: a transmission unit configured to, when an activation command for the secondary cell in a deactive state is received, start reporting channel state indicator information in the secondary cell to a radio base station at predetermined timing before a time point when transition of the secondary cell to an active state is completed, wherein the transmission unit reports the channel state indicator information to the radio base station at predetermined intervals even in a time period from a time point when the reporting of the channel state indicator information is started to a time point when the transition of the secondary cell to the active state is completed. a transmission unit configured to, when an activation command for the secondary cell in a deactive state is received, start reporting channel state indicator information in the secondary cell to a radio base station at predetermined timing before a time point when transition of the secondary cell to an active state is completed, wherein the transmission unit reports the channel state indicator information to the radio base station at predetermined intervals even in a time period from a time point when the reporting of the channel state indicator information is started to a time point when the transition of the secondary cell to the active state is completed.
A method for discovering and interacting with services, the method being implemented by a requestor, the method being characterized by the steps of: multicasting a service command, being an instruction to a service to perform an operation, to a multicast group of service providers; receiving, in response to the service command and via unicast, a response message from a provider of the service, wherein the response message includes response data and discovery information about the service and the provider, wherein the discovery information enables the requester to interact with the service; processing the response data; and processing the discovery information. multicasting a service command, being an instruction to a service to perform an operation, to a multicast group of service providers; receiving, in response to the service command and via unicast, a response message from a provider of the service, wherein the response message includes response data and discovery information about the service and the provider, wherein the discovery information enables the requester to interact with the service; processing the response data; and processing the discovery information.
A scanning method for measuring rotationally and non-rotationally symmetric shapes of aspherical wavefronts and surfaces, the method comprising providing a scanning axis; defining at least one known shape of known origin along the scanning axis; selectively moving an unknown aspherical shape along the scanning axis relative to the known origin so that the known shape intersects the unknown aspherical shape at its apex and at radial positions where the known shape and the aspherical surface intersect at points of common tangency to generate an interference signal whose intensity varies with scan position and in accordance with the optical path length difference, p, between the apex and radial positions; interferometrically measuring the axial distance, v, by which the aspherical shape is moved with respect to the origin and the optical path length difference, p, between the apex of the aspherical shape and the apex of the circles of curvature that intersect the aspherical shape at the common points of tangency as the aspherical shape and the known shape axially scan one another; calculating the coordinates of the aspherical shape wherever the circles of curvature have intersected the aspherical shape at common points of tangency and in correspondence with the interferometrically measured distances, v and p; and determining the unknown shape of the aspheric shape in accordance with the coordinate values and surface slopes at the common points of tangency.
A connection device for a flexible hose, the connection device comprising a first and second hose-holder (18, 16), a first and second pressing ring nut (4, 7) having both a tubular outer body with the same constant outer diameter, the first hose-holder being mounted on an end portion of the flexible hose and locked in position by means of the first pressing ring nut, the second hose-holder being mounted on the other end portion of the flexible hose and locked in position by means of the second pressing ring nut, the connection device further comprising an element for mutually connecting said first and second hose-holders (18, 16), the element comprising a substantially tubular body having a longitudinal hole, said element comprising a circulating ball portion for the connection to one of said first or second hose-holder (18, 16), wherein the inner diameter of said second hose-holder is the same as the inner diameter of said first hose-holder, and wherein the largest outer diameter of said element is smaller than the outer diameter of said first pressing ring nut and smaller than the outer diameter of said second pressing ring nut.