A device for transcutaneous application of carbon dioxide for treatment of chronic wounds or neuropathy comprising at least: - a therapeutic chamber comprising at least a portion to receive a part of a patient's body to which the carbon dioxide is to be applied, - a CO 2 distribution system, comprising o a first pipe with a first valve for supplying CO 2 from a tank or a reservoir, o a second pipe with a second valve for suction of air out of the chamber; - at least one tank for storing CO 2 suitably connected to the CO 2 distribution system or preferably to a reservoir, characterized in that the device further comprises: - an inlet/outlet pipe connecting the chamber with a CO 2 distribution system, wherein the inlet/outlet pipe is connected to the chamber with a suitable element or a valve; - and in that the CO 2 distribution system comprises a housing: wherein the first and second pipe are combined into the inlet/outlet pipe upstream of the valves; and the system further comprises: ∘ at least one device for ensuring air flow through the said valves and inlet/outlet pipe, preferably a ventilator or a pump; ∘ preferably at least one airflow measuring device (41'b, 42'b, 42"b) for measuring the air flow through the valve on the inlet/outlet pipe or through any valve; ∘ preferably a reservoir for CO 2, where it is stored at the pressure of 1 to 5 bar, connected to the second pipe; ∘ an outlet pipe for leading the used air from the chamber through the wall to the external environment of the building where the device is installed; and - and in that the inlet/outlet pipe is coupled to the chamber with a gate valve, which comprises: ∘ a rotating part; ∘ preferably a washer; ∘ a seal; and ∘ a static part adapted for introduction into the inlet/outlet pipe; ∘ wherein the rotating part has two removable parts, which are screwed into place from the interior of the chamber, the seal is installed in the static part, while the preferred washer prevents rotation of the chamber, when the rotating part is screwed into place with the static part, and wherein the rotating part and the static part have corresponding treads, which can interlock so that air leakage is prevented. - a therapeutic chamber comprising at least a portion to receive a part of a patient's body to which the carbon dioxide is to be applied, - a CO 2 distribution system, comprising o a first pipe with a first valve for supplying CO 2 from a tank or a reservoir, o a second pipe with a second valve for suction of air out of the chamber; o a first pipe with a first valve for supplying CO 2 from a tank or a reservoir, o a second pipe with a second valve for suction of air out of the chamber; - at least one tank for storing CO 2 suitably connected to the CO 2 distribution system or preferably to a reservoir, - an inlet/outlet pipe connecting the chamber with a CO 2 distribution system, wherein the inlet/outlet pipe is connected to the chamber with a suitable element or a valve; - and in that the CO 2 distribution system comprises a housing: wherein the first and second pipe are combined into the inlet/outlet pipe upstream of the valves; and the system further comprises: ∘ at least one device for ensuring air flow through the said valves and inlet/outlet pipe, preferably a ventilator or a pump; ∘ preferably at least one airflow measuring device (41'b, 42'b, 42"b) for measuring the air flow through the valve on the inlet/outlet pipe or through any valve; ∘ preferably a reservoir for CO 2, where it is stored at the pressure of 1 to 5 bar, connected to the second pipe; ∘ an outlet pipe for leading the used air from the chamber through the wall to the external environment of the building where the device is installed; and ∘ at least one device for ensuring air flow through the said valves and inlet/outlet pipe, preferably a ventilator or a pump; ∘ preferably at least one airflow measuring device (41'b, 42'b, 42"b) for measuring the air flow through the valve on the inlet/outlet pipe or through any valve; ∘ preferably a reservoir for CO 2, where it is stored at the pressure of 1 to 5 bar, connected to the second pipe; ∘ an outlet pipe for leading the used air from the chamber through the wall to the external environment of the building where the device is installed; and - and in that the inlet/outlet pipe is coupled to the chamber with a gate valve, which comprises: ∘ a rotating part; ∘ preferably a washer; ∘ a seal; and ∘ a static part adapted for introduction into the inlet/outlet pipe; ∘ wherein the rotating part has two removable parts, which are screwed into place from the interior of the chamber, the seal is installed in the static part, while the preferred washer prevents rotation of the chamber, when the rotating part is screwed into place with the static part, and wherein the rotating part and the static part have corresponding treads, which can interlock so that air leakage is prevented. ∘ a rotating part; ∘ preferably a washer; ∘ a seal; and ∘ a static part adapted for introduction into the inlet/outlet pipe; ∘ wherein the rotating part has two removable parts, which are screwed into place from the interior of the chamber, the seal is installed in the static part, while the preferred washer prevents rotation of the chamber, when the rotating part is screwed into place with the static part, and wherein the rotating part and the static part have corresponding treads, which can interlock so that air leakage is prevented.