A compound of formula I wherein X ---- Y ---- W represents X-Y=W or W-Y=X; X and W independently represent N, O, S or CR 2; Y is N or CR 1; and R 1 is selected from the group consisting of H and C 1 -C 6 alkyl; wherein H and the C 1 -C 6 alkyl are independently and optionally substituted with 1-3 substituents selected independently from the group consisting of halogen, hydroxy, amino, C 1 -C 6 alkylamino, diC 1 -C 6 alkylamino, azinyl, azetidinyl, oxetanyl, thietanyl, homopiperidinyl, oxepanyl, thiepanyl, oxazepinyl, diazepinyl, thiazepinyl, 1,2,3,6-tetrahydropyridinyl, 2-pyrrolinyl, 3-pyrrolinyl, indolinyl, 2H-pyranyl, 4H-pyranyl, dioxanyl, 1,3-dioxolanyl, pyrazolinyl, dithianyl, dithiolanyl, dihydropyranyl, dihydrothienyl, dihydrofuranyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, 3-azabicyclo[3.1.0]hexyl, 3-azabicyclo[4.1.0]heptyl, 3H-indolyl, quinolizinyl, C 1 -C 4 alkoxy, and C 1 -C 4 alkylthiol; R 2 is selected from the group consisting of H and C 1 -C 10 alkyl, where the C 1 -C 10 alkyl is unsubstituted or substituted with 1-3 substituents independently selected from halogen, hydroxyl, or C 1 - C 4 alkyl; R 3 is selected from the group consisting of H, C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkoxy, and C 3 -C 10 cycloalkylalkyl, where the C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkoxy and C 3 -C 10 cycloalkylalkyl are independently unsubstituted or substituted with 1-3 substituents independently selected from halogen, hydroxyl, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy; R 3' is H; R 4, R 5, R 6, R 7 and R 8 are independently selected from the group consisting of H, halogen, SR 9, and OR 9; R 9 is selected from the group consisting of hydrogen and C 1 -C 10 alkyl; R 13 is selected from the groups consisting of H and C 1 -C 6 alkyl; R 14 is selected from the groups consisting of H and C 1 -C 6 alkyl; or a pharmaceutically acceptable salt, solvate, polymorph, or tautomer thereof. X and W independently represent N, O, S or CR 2; Y is N or CR 1; and R 1 is selected from the group consisting of H and C 1 -C 6 alkyl; wherein H and the C 1 -C 6 alkyl are independently and optionally substituted with 1-3 substituents selected independently from the group consisting of halogen, hydroxy, amino, C 1 -C 6 alkylamino, diC 1 -C 6 alkylamino, azinyl, azetidinyl, oxetanyl, thietanyl, homopiperidinyl, oxepanyl, thiepanyl, oxazepinyl, diazepinyl, thiazepinyl, 1,2,3,6-tetrahydropyridinyl, 2-pyrrolinyl, 3-pyrrolinyl, indolinyl, 2H-pyranyl, 4H-pyranyl, dioxanyl, 1,3-dioxolanyl, pyrazolinyl, dithianyl, dithiolanyl, dihydropyranyl, dihydrothienyl, dihydrofuranyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, 3-azabicyclo[3.1.0]hexyl, 3-azabicyclo[4.1.0]heptyl, 3H-indolyl, quinolizinyl, C 1 -C 4 alkoxy, and C 1 -C 4 alkylthiol; R 2 is selected from the group consisting of H and C 1 -C 10 alkyl, where the C 1 -C 10 alkyl is unsubstituted or substituted with 1-3 substituents independently selected from halogen, hydroxyl, or C 1 - C 4 alkyl; R 3 is selected from the group consisting of H, C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkoxy, and C 3 -C 10 cycloalkylalkyl, where the C 1 -C 10 alkyl, C 1 -C 10 alkoxy, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkoxy and C 3 -C 10 cycloalkylalkyl are independently unsubstituted or substituted with 1-3 substituents independently selected from halogen, hydroxyl, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy; R 3' is H; R 4, R 5, R 6, R 7 and R 8 are independently selected from the group consisting of H, halogen, SR 9, and OR 9; R 9 is selected from the group consisting of hydrogen and C 1 -C 10 alkyl; R 13 is selected from the groups consisting of H and C 1 -C 6 alkyl; R 14 is selected from the groups consisting of H and C 1 -C 6 alkyl;