mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula or a pharmaceutically acceptable salt thereof; wherein, R 1 is H or C 1 -C 6 alkyl; and Hal is halogen; for use in the treatment of a disease and/or disorder selected from asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, systemic onset juvenile idiopathic arthritis (SOJIA), gout, pemphigus vulgaris, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, thrombotic thrombocytopenic purpura, chronic autoimmune urticaria, allergy (atopic dermatitis, contact dermatitis, allergic rhinitis), atherosclerosis, type 1 diabetes, type 2 diabetes, inflammatory bowel disease, ulcerative colitis, morbus Crohn, pancreatitis, glomerolunephritis, Goodpasture's syndrome, Hashimoto's thyroiditis, Grave's disease, antibody-mediated transplant rejection, graft versus host disease, B cell-mediated hyperacute, or acute and chronic transplant rejection. R 1 is H or C 1 -C 6 alkyl; and Hal is halogen; for use in the treatment of a disease and/or disorder selected from asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, systemic onset juvenile idiopathic arthritis (SOJIA), gout, pemphigus vulgaris, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, multiple sclerosis, myasthenia gravis, Sjögren's syndrome, thrombotic thrombocytopenic purpura, chronic autoimmune urticaria, allergy (atopic dermatitis, contact dermatitis, allergic rhinitis), atherosclerosis, type 1 diabetes, type 2 diabetes, inflammatory bowel disease, ulcerative colitis, morbus Crohn, pancreatitis, glomerolunephritis, Goodpasture's syndrome, Hashimoto's thyroiditis, Grave's disease, antibody-mediated transplant rejection, graft versus host disease, B cell-mediated hyperacute, or acute and chronic transplant rejection.
An apparatus (306, 302, 305) for measuring pH values, the apparatus comprising: a volume defined by at least one surface having one or more confinement regions, a pH sensor operationally associated with at least one confinement region for measuring transient pH values of a reagent in such at least one confinement region; characterized by the volume containing the reagent mixed with particles comprising an immobile buffer and having an average size and shape such that substantially no said particles can enter any confinement region. a volume defined by at least one surface having one or more confinement regions, a pH sensor operationally associated with at least one confinement region for measuring transient pH values of a reagent in such at least one confinement region; characterized by the volume containing the reagent mixed with particles comprising an immobile buffer and having an average size and shape such that substantially no said particles can enter any confinement region.
A child chair apparatus comprising: a supporting device; and a seat device disposed on the supporting device, the seat device including: a fixing component disposed on the supporting device, the fixing component including a first shaft and a second shaft; and a seat component including an oscillating base and an adjusting base, the oscillating base and the adjusting base being slidably connected to the first shaft and the second shaft respectively, such that the seat component is slidably disposed on the fixing component. a supporting device; and a seat device disposed on the supporting device, the seat device including: a fixing component disposed on the supporting device, the fixing component including a first shaft and a second shaft; and a seat component including an oscillating base and an adjusting base, the oscillating base and the adjusting base being slidably connected to the first shaft and the second shaft respectively, such that the seat component is slidably disposed on the fixing component. a fixing component disposed on the supporting device, the fixing component including a first shaft and a second shaft; and a seat component including an oscillating base and an adjusting base, the oscillating base and the adjusting base being slidably connected to the first shaft and the second shaft respectively, such that the seat component is slidably disposed on the fixing component.
A system for performing vessel analysis, comprising display means for displaying a three-dimensional image representing at least a tubular structure; indicating means for enabling a user to indicate a position on a vessel of the tubular structure, for obtaining an indicated position, wherein the indicating means is arranged for being responsive to a mouse move event; and identifying means for identifying a portion of the tubular structure situated around the indicated position, including any bifurcations, and extending up to a predetermined distance measure from the indicated position, for obtaining an identified portion; wherein the display means is arranged for displaying a graphical annotation, up to said predetermined distance from the indicated position, in the displayed three-dimensional image, indicative of the identified portion of the tubular structure; and wherein the identifying means and/or the display means are configured to be activated to provide an updated identified portion when a mouse move event is detected.
No-frost refrigeration device having at least one storage compartment, an evaporator which is arranged in a chamber separated from the storage compartment and can be switched on and off alternately, and a ventilator for circulating air between the storage compartment and the chamber of the evaporator, wherein in a switched-on phase of the evaporator a mean circulation rate of the ventilator is made variable, characterised in that in the switched-on phase of the evaporator, the ventilator can be switched off temporarily and a control circuit is configured to control the operation of the evaporator and the ventilator in order to operate the ventilator intermittently when the evaporator is switched on, wherein the no-frost refrigeration device has a selector switch, on which a pulse-duty factor for the intermittent operation of the ventilator can be adjusted, or the control circuit is coupled to at least one climate sensor and regulates the pulse-duty factor as a function of at least one climate parameter detected by the climate sensor.
A polypeptide, wherein the polypeptide consists of 16-23, preferably 16-21, or most preferably 21 consecutive amino acids of the amino acid sequence of SEQ ID NO: 1.
A method of producing a heat stress tolerant plant, comprising: a) providing a nucleic acid encoding a MYB subgroup-14 polypeptide_selected from the group consisting of MYB36, MYB37, MYB38, MYB68, MYB84, and MYB87; b) inserting said nucleic acid into a vector; c) transforming a plant, a tissue culture, or a plant cell with said vector to obtain a transformed plant, tissue culture, or plant cell with an increased expression of said MYB subgroup-14 polypeptide; d) growing said transformed plant or regenerating a plant from said transformed tissue culture or plant cell, wherein a heat stress tolerant plant is produced which has an increased heat stress tolerance as compared to a wild type plant. a) providing a nucleic acid encoding a MYB subgroup-14 polypeptide_selected from the group consisting of MYB36, MYB37, MYB38, MYB68, MYB84, and MYB87; b) inserting said nucleic acid into a vector; c) transforming a plant, a tissue culture, or a plant cell with said vector to obtain a transformed plant, tissue culture, or plant cell with an increased expression of said MYB subgroup-14 polypeptide; d) growing said transformed plant or regenerating a plant from said transformed tissue culture or plant cell, wherein a heat stress tolerant plant is produced which has an increased heat stress tolerance as compared to a wild type plant.
Covering composition in the form of a spray for application to body surfaces, containing - at least one water-resistant polymer in an amount of 1 to 20% by weight, - at least one pigment in an amount of 2 to 25% by weight, - at least one solvent for the water-resistant polymer in an amount of 40 to 80% by weight, - up to 40% by weight of propellant, - up to 40% by weight of additives, wherein the data by weight are based on the total composition, characterized in that it contains polyisobutylene as the water-resistant polymer and in that the solvent is selected from acetone, isopropanol, pentane, hexane, heptane and/or methylal. - at least one water-resistant polymer in an amount of 1 to 20% by weight, - at least one pigment in an amount of 2 to 25% by weight, - at least one solvent for the water-resistant polymer in an amount of 40 to 80% by weight, - up to 40% by weight of propellant, - up to 40% by weight of additives,
A method for producing a binder composition, wherein the method comprises: i) providing a raw material of crushed lignin agglomerates, wherein at least 90 weight-% of the crushed lignin agglomerates have a particle size of at most 10 mm; ii) dissolving the provided raw material into an aqueous solvent composition, wherein at least 95 weight-% of the total amount of the raw material provided into the aqueous solvent composition is dissolved into the aqueous solvent composition within at most 60 minutes; and iii) heating the composition formed in step ii) at a temperature of 60 - 150 °C in the presence of crosslinking agent and compound selected from the class of phenols for polymerizing the raw material, the crosslinking agent, and the compound selected from the class of phenols. i) providing a raw material of crushed lignin agglomerates, wherein at least 90 weight-% of the crushed lignin agglomerates have a particle size of at most 10 mm; ii) dissolving the provided raw material into an aqueous solvent composition, wherein at least 95 weight-% of the total amount of the raw material provided into the aqueous solvent composition is dissolved into the aqueous solvent composition within at most 60 minutes; and iii) heating the composition formed in step ii) at a temperature of 60 - 150 °C in the presence of crosslinking agent and compound selected from the class of phenols for polymerizing the raw material, the crosslinking agent, and the compound selected from the class of phenols.
A thermal insulation product, in particular at least in the form of a solid foam, this product being formed from mineral particles, other than aerogel particles, with a submicron porosity such that the bulk density thereof is less than 280 kg/m 3, and such that the density of the cake obtained by drying at 40°C of a dispersion of 16% by weight of these particles in water is less than 600 kg/m 3.
A fluid medium dispensing system comprising: a container for storing a fluid medium under pressure, the container comprising a neck defining an opening; a valve; and a valve cup adapted to support the valve and close the opening of the container, contiguous portions of the valve cup and the neck being comprised of plastics materials, wherein the valve cup comprises an inner part that is inserted in the neck by pressing and located in the opening of the container and wherein the valve cup is an interference fit in the neck of the container with contact between said plastics materials of the valve cup and of the neck around a whole periphery of the inner part of the valve cup and wherein an outer diameter of the inner part of the valve cup prior to pressing of the valve cup into the opening of the container is between 0.05 mm and 0.15 mm inclusive greater than the inner diameter of the opening in order to create the interference fit and wherein said plastics materials of the valve cup and the neck have been fused to form a molten weld seam (15a, 15b) by laser welding thereby sealing the container. a container for storing a fluid medium under pressure, the container comprising a neck defining an opening; a valve; and a valve cup adapted to support the valve and close the opening of the container, contiguous portions of the valve cup and the neck being comprised of plastics materials, wherein the valve cup comprises an inner part that is inserted in the neck by pressing and located in the opening of the container and wherein the valve cup is an interference fit in the neck of the container with contact between said plastics materials of the valve cup and of the neck around a whole periphery of the inner part of the valve cup and wherein an outer diameter of the inner part of the valve cup prior to pressing of the valve cup into the opening of the container is between 0.05 mm and 0.15 mm inclusive greater than the inner diameter of the opening in order to create the interference fit and wherein said plastics materials of the valve cup and the neck have been fused to form a molten weld seam (15a, 15b) by laser welding thereby sealing the container.
A method for waste treatment comprising: a. providing an initial volume of heterogeneous waste comprising a plastic component comprising at least one thermoplastic component, the amount of plastic component in said heterogeneous waste being at most 50% by weight of said waste; at least one non-plastic component comprising at least one organic material; b. heating said initial volume of heterogeneous waste in a manner so as to allow at least a portion of the thermoplastic component to melt, whereby at least a portion of pieces of said heterogeneous waste are encapsulated, thereby forming a composite material; c. processing said composite material, said processing comprises cooling the composite material. a. providing an initial volume of heterogeneous waste comprising a plastic component comprising at least one thermoplastic component, the amount of plastic component in said heterogeneous waste being at most 50% by weight of said waste; at least one non-plastic component comprising at least one organic material; b. heating said initial volume of heterogeneous waste in a manner so as to allow at least a portion of the thermoplastic component to melt, whereby at least a portion of pieces of said heterogeneous waste are encapsulated, thereby forming a composite material; c. processing said composite material, said processing comprises cooling the composite material.
A reaction device with air-lift type internal circulation which includes: - a vertical cylindrical volume, - more than one draft tube vertical element positioned within the cylindrical volume in such a manner as to form a gap with the walls of said volume, - more than one gas distributor, each of which is positioned on the bottom of said device; - each vertical internal element has an internal diameter which increases along the vertical axis of said element, said device being characterised in that: - the ratio between the total height of the reaction device and the internal diameter of the reaction device is less than 1, and - the ratio between the cross-sectional area of the gap and the cross-sectional area of the draft tube vertical internal element ranges from 1 to 3. - a vertical cylindrical volume, - more than one draft tube vertical element positioned within the cylindrical volume in such a manner as to form a gap with the walls of said volume, - more than one gas distributor, each of which is positioned on the bottom of said device; - each vertical internal element has an internal diameter which increases along the vertical axis of said element, - the ratio between the total height of the reaction device and the internal diameter of the reaction device is less than 1, and - the ratio between the cross-sectional area of the gap and the cross-sectional area of the draft tube vertical internal element ranges from 1 to 3.
A battery device comprising: a battery cell pack including a plurality of battery cells; a layered structure disposed on top of the battery cell pack, said structure including an electrically conductive layer, an insulating material, and a cover layer or coating forming an upper surface of the layered structure; and a housing, in which said battery cell pack and said structure are arranged; wherein said electrically conductive layer is arranged in contact with the battery cell pack to electrically connect the plurality of battery cells, and said electrically conductive layer comprises a plurality of openings; said insulating material includes a plurality of weakened portions or cuts extending through the insulating material; said cover layer or coating includes a heat- and fire-resistant material comprising mica or a ceramic, and further comprises a plurality of weakened portions or pre-cuts forming flaps, a flap being openable by an increase in pressure resulting from burn-out of a battery cell; and said structure is arranged such that, in case of burnout of a cell of said plurality of battery cells, a ventilation passage is formed over said cell through: an opening of said plurality of openings in said electrically conductive layer, a weakened portion or cut in said insulating material, and an opened flap of said flaps in the cover layer or coating. a battery cell pack including a plurality of battery cells; a layered structure disposed on top of the battery cell pack, said structure including an electrically conductive layer, an insulating material, and a cover layer or coating forming an upper surface of the layered structure; and a housing, in which said battery cell pack and said structure are arranged; wherein said electrically conductive layer is arranged in contact with the battery cell pack to electrically connect the plurality of battery cells, and said electrically conductive layer comprises a plurality of openings; said insulating material includes a plurality of weakened portions or cuts extending through the insulating material; said cover layer or coating includes a heat- and fire-resistant material comprising mica or a ceramic, and further comprises a plurality of weakened portions or pre-cuts forming flaps, a flap being openable by an increase in pressure resulting from burn-out of a battery cell; and said structure is arranged such that, in case of burnout of a cell of said plurality of battery cells, a ventilation passage is formed over said cell through: an opening of said plurality of openings in said electrically conductive layer, a weakened portion or cut in said insulating material, and an opened flap of said flaps in the cover layer or coating. an opening of said plurality of openings in said electrically conductive layer, a weakened portion or cut in said insulating material, and an opened flap of said flaps in the cover layer or coating.
A method for determining whether a breast cancer in a patient is resistant to treatment with an anti-mitotic agent-antibody conjugate comprising an anti-mitotic agent selected from an auristatin and a maytansinoid covalently linked to an antibody, said method comprising detecting whether the ABCC3 gene is amplified or overexpressed in a test breast cancer sample from the patient, wherein amplification or overexpression of the ABCC3 gene indicates that the breast cancer is resistant to treatment with the anti-mitotic agent-antibody conjugate.
Rubber hose comprising a distinctly colored inner wear indicator integrated into its liner, wherein the inner wear indicator is disposed at a distance b from an inner surface of the liner, wherein b is less than 40% of thickness v of the liner, and wherein the height h of the wear indicator, measured perpendicularly to a longitudinal axis of the hose, falls between 1% to 90% of liner thickness v; characterised in that the inner wear indicator has profile which is: o applied in a spiral and has a triangular cross-section, o applied in a spiral and has a multiple triangular cross-section, o a triangular cross-section laid in ring-like shape, perpendicular to the longitudinal axis, o a multiple triangular cross-section laid in a ring-like shape, placed perpendicular to the longitudinal axis, or o essentially conical elements placed in a spot-like pattern. o applied in a spiral and has a triangular cross-section, o applied in a spiral and has a multiple triangular cross-section, o a triangular cross-section laid in ring-like shape, perpendicular to the longitudinal axis, o a multiple triangular cross-section laid in a ring-like shape, placed perpendicular to the longitudinal axis, or o essentially conical elements placed in a spot-like pattern.
Device for determining the consumption period of a gas by a patient comprising: - an internal gas passage with a gas inlet and a gas outlet, - connection means enabling the smooth connection of the device to a gas dispersion socket, - adjustment means allowing a desired gas consumption period (T fixed) to be adjusted, - display means allowing at least the gas consumption period (T fixed) to be displayed, - means for determining the gas consumption period (5, 6) designed to measure the total gas consumption period (T consumption) during which the gas circulates in said internal gas passage, from the gas inlet towards the gas outlet, - means for processing information able to and designed to compare the total gas consumption period (T consumption) determined by the means for determining the gas consumption period (5, 6) with the desired gas consumption period (T fixed), and - means for interrupting flow, designed to interrupt any gas circulation in said gas passage when the means for processing information determine that the total gas consumption period (T consumption) is longer than or equal to the desired gas consumption period (T fixed). - an internal gas passage with a gas inlet and a gas outlet, - connection means enabling the smooth connection of the device to a gas dispersion socket, - adjustment means allowing a desired gas consumption period (T fixed) to be adjusted, - display means allowing at least the gas consumption period (T fixed) to be displayed, - means for determining the gas consumption period (5, 6) designed to measure the total gas consumption period (T consumption) during which the gas circulates in said internal gas passage, from the gas inlet towards the gas outlet, - means for processing information able to and designed to compare the total gas consumption period (T consumption) determined by the means for determining the gas consumption period (5, 6) with the desired gas consumption period (T fixed), and - means for interrupting flow, designed to interrupt any gas circulation in said gas passage when the means for processing information determine that the total gas consumption period (T consumption) is longer than or equal to the desired gas consumption period (T fixed).