mhurhangee/ep-ind-claims huggingface dataset:
A device for dispensing and applying a liquid, semi-fluid or pasty cosmetic or care product comprising an elongate hollow rotary body and an elongate hollow outer barrel which are butted to each other, and rotatable relative to each other, an application tip being fastened at an end of the rotary body, said rotary body and outer barrel forming an inner volume in which are provided: a bored cylinder, comprising a longitudinal duct; and an inner barrel, comprising an open end by which is inserted the bored cylinder and an end which is closed so as to form a reservoir for the cosmetic or care product, characterized in that the bored cylinder is translationally fixed relative to the rotary body, inside which it extends, and in that the device comprises a mechanism for transforming rotation of the rotary body relative to the outer barrel into a translational movement of the inner barrel relative to the bored cylinder inside the inner volume formed by said rotary body and outer barrel. an application tip being fastened at an end of the rotary body, said rotary body and outer barrel forming an inner volume in which are provided: a bored cylinder, comprising a longitudinal duct; and an inner barrel, comprising an open end by which is inserted the bored cylinder and an end which is closed so as to form a reservoir for the cosmetic or care product, a bored cylinder, comprising a longitudinal duct; and an inner barrel, comprising an open end by which is inserted the bored cylinder and an end which is closed so as to form a reservoir for the cosmetic or care product, characterized in that the bored cylinder is translationally fixed relative to the rotary body, inside which it extends, and in that the device comprises a mechanism for transforming rotation of the rotary body relative to the outer barrel into a translational movement of the inner barrel relative to the bored cylinder inside the inner volume formed by said rotary body and outer barrel.
A pharmaceutical formulation comprising a recombinant protein comprising (i) interleukin-12 (IL-12) and (ii) an antibody binding the extra-domain B (ED-B) of fibronectin, or a target binding fragment thereof, the formulation comprising: • Histidine, Sucrose and EDTA, adjusted to have a pH of 8.0 ± 0.3 • citric acid, sodium citrate, Sucrose, Glycerol, EDTA, adjusted to have a pH of 6.0 ± 0.3; or • Hepes, NaCl, Mannitol, Glycerol, EDTA, adjusted to have a pH of 7.0 ± 0.3. • Histidine, Sucrose and EDTA, adjusted to have a pH of 8.0 ± 0.3 • citric acid, sodium citrate, Sucrose, Glycerol, EDTA, adjusted to have a pH of 6.0 ± 0.3; or • Hepes, NaCl, Mannitol, Glycerol, EDTA, adjusted to have a pH of 7.0 ± 0.3.
Device for establishing centring data for spectacles for a test subject, comprising a recording unit, which is actuatable by a computer and records electronic images of the bespectacled eye area of the test subject, and comprising a fixation apparatus for generating a fixation pattern for the test subject, characterized in that the recording unit is arranged behind a splitter element guiding the fixation pattern into the field of view of the test subject and in that the fixation apparatus is a fixation apparatus generating at least one speckle pattern as fixation pattern.
A polynucleotide comprising: a) a nucleic acid sequence comprising an open reading frame for a circularly permuted luciferase which comprises a cyclic nucleotide binding site at sequences corresponding to the N-terminus and/or C-terminus of a corresponding nonpermuted luciferase, which luciferase is permuted at a site or in a region which in the corresponding nonpermuted luciferase is tolerant to modification, and wherein the luminescence activity of the circularly permuted luciferase is detectable and is altered upon binding of a cyclic nucleotide; or b) a nucleic acid sequence comprising an open reading frame for a modified beetle luciferase, wherein the modified beetle luciferase comprises a cyclic nucleotide binding site relative to a corresponding unmodified beetle luciferase, wherein the cyclic nucleotide binding site is at a residue or in a region in a beetle luciferase sequence which is tolerant to modification and is at the C-terminus of the modified beetle luciferase, and wherein the luminescence activity of the modified beetle luciferase is detectable and is altered upon binding of a cyclic nucleotide. a) a nucleic acid sequence comprising an open reading frame for a circularly permuted luciferase which comprises a cyclic nucleotide binding site at sequences corresponding to the N-terminus and/or C-terminus of a corresponding nonpermuted luciferase, which luciferase is permuted at a site or in a region which in the corresponding nonpermuted luciferase is tolerant to modification, and wherein the luminescence activity of the circularly permuted luciferase is detectable and is altered upon binding of a cyclic nucleotide; or b) a nucleic acid sequence comprising an open reading frame for a modified beetle luciferase, wherein the modified beetle luciferase comprises a cyclic nucleotide binding site relative to a corresponding unmodified beetle luciferase, wherein the cyclic nucleotide binding site is at a residue or in a region in a beetle luciferase sequence which is tolerant to modification and is at the C-terminus of the modified beetle luciferase, and wherein the luminescence activity of the modified beetle luciferase is detectable and is altered upon binding of a cyclic nucleotide.
A rotor disk assembly comprising: a rotor disk; and a retention ring coupled to the rotor disk, wherein the retention ring dimensions vary circumferentially such that the retention ring is configured to adjust a modal frequency response of the rotor disk; characterized in that the dimensions of the retention ring are tuned to vary circumferentially in response to a predicted modal frequency response. a rotor disk; and a retention ring coupled to the rotor disk, wherein the retention ring dimensions vary circumferentially such that the retention ring is configured to adjust a modal frequency response of the rotor disk; characterized in that the dimensions of the retention ring are tuned to vary circumferentially in response to a predicted modal frequency response.
A method, comprising: operating a communication device in a communication network; the communication device receiving a first packet (140, 500) with an indication that the first packet is part of a particular packet train, the packet train comprising a plurality of packets to be transmitted in succession; the communication device preventing transmission until receiving a final packet of the packet train; and the communication device storing received packets of the particular packet train while preventing the transmission; the method characterised by operating the communication device according to a particular frequency hopping sequence, with the communication device individually picking its own hopping schedule parameters independent of any other node in the communication network. operating a communication device in a communication network; the communication device receiving a first packet (140, 500) with an indication that the first packet is part of a particular packet train, the packet train comprising a plurality of packets to be transmitted in succession; the communication device preventing transmission until receiving a final packet of the packet train; and the communication device storing received packets of the particular packet train while preventing the transmission; the method characterised by operating the communication device according to a particular frequency hopping sequence, with the communication device individually picking its own hopping schedule parameters independent of any other node in the communication network.
A cable and building services management system, comprising: at least one support sheet including a plurality of surface fixing apertures for fixing the sheet to a surface, and a plurality of protrusions on an upper surface of the sheet, wherein each protrusion has at least one securing aperture for securing one or more cables and/or building service lines to the sheet; and a plurality of fasteners, wherein each fastener is adapted to engage with a securing aperture so as to secure one or more cables and/or building service lines to the sheet by threading the fastener through the securing aperture and around the cable; wherein the support sheet is formed from a metal or alloy of a thickness in the range of 0.5mm to 5mm suitable for the sheet to be dispensed from a roll; wherein the protrusions are formed in such a way that a corresponding plurality of depressions are formed on a lower surface of the sheet; and wherein the protrusions and depressions are equidistantly spaced about the at least one support sheet, such that the depressions of a first sheet can receive the protrusions of a second sheet when the first sheet is placed upon the second sheet. at least one support sheet including a plurality of surface fixing apertures for fixing the sheet to a surface, and a plurality of protrusions on an upper surface of the sheet, wherein each protrusion has at least one securing aperture for securing one or more cables and/or building service lines to the sheet; and a plurality of fasteners, wherein each fastener is adapted to engage with a securing aperture so as to secure one or more cables and/or building service lines to the sheet by threading the fastener through the securing aperture and around the cable; wherein the support sheet is formed from a metal or alloy of a thickness in the range of 0.5mm to 5mm suitable for the sheet to be dispensed from a roll; wherein the protrusions are formed in such a way that a corresponding plurality of depressions are formed on a lower surface of the sheet; and wherein the protrusions and depressions are equidistantly spaced about the at least one support sheet, such that the depressions of a first sheet can receive the protrusions of a second sheet when the first sheet is placed upon the second sheet.
Wind turbine, comprising a tower and a nacelle rotatable relative to the tower by means of a yaw bearing arrangement comprising a yaw ring fixed relative to the tower, several upper sliding pads arranged between the upper side of the yaw ring and a sliding structure of the nacelle and several lower sliding pads arranged between the lower side of the yaw ring and the sliding structure, characterized in that the sliding pads (19, 23) are fixed to the yaw ring and that at least one radial opening (27, 28) is provided in the sliding structure allowing access to the upper or lower sliding pads (19, 23).
A production plant with an applicator for applying a compressed fluid to the respective surface of metal sheets and with a transport device downstream of the applicator for the lying transport of a plurality of metal sheets transported along a transport path one after the other, characterized in that the transport device has a scale for measuring the respective mass of these metal sheets arranged in the transport path of the metal sheets, wherein the scale is configured measuring the mass of the metal sheets together with the compression fluid applied to their respective surface or only determining the mass of the compression fluid applied to the respective surface, wherein the scale is configured reporting its measured or determined result respectively to a control device belonging to the production plant and/or to the applicator.
An access device for placing a medical article within a body space, the device comprising an assembly, the assembly comprising: a needle having an elongated needle body and a needle hub from which the needle body extends; a dilator slideably disposed on the needle body, the dilator comprising a dilator hub and an elongated dilator shaft that extends from the dilator hub; a sheath slideably disposed on the dilator shaft, the sheath comprising a tubular sheath body and a sheath hub coupled with the tubular sheath body; the device further comprising: a holding bracket not being part of the assembly, the holding bracket being releasably engaged with the needle hub and the sheath hub, the holding bracket securing the dilator hub in position with respect to the needle hub and the sheath hub, and the holding bracket being configured to be removed from the assembly. a needle having an elongated needle body and a needle hub from which the needle body extends; a dilator slideably disposed on the needle body, the dilator comprising a dilator hub and an elongated dilator shaft that extends from the dilator hub; a sheath slideably disposed on the dilator shaft, the sheath comprising a tubular sheath body and a sheath hub coupled with the tubular sheath body; the device further comprising: a holding bracket not being part of the assembly, the holding bracket being releasably engaged with the needle hub and the sheath hub, the holding bracket securing the dilator hub in position with respect to the needle hub and the sheath hub, and the holding bracket being configured to be removed from the assembly. a holding bracket not being part of the assembly, the holding bracket being releasably engaged with the needle hub and the sheath hub, the holding bracket securing the dilator hub in position with respect to the needle hub and the sheath hub, and the holding bracket being configured to be removed from the assembly.
Positioning device for a movable furniture part, which can be guided in movement by a guiding device on a furniture body of a piece of furniture, which positioning device is provided for positioning the furniture part on a rear section of the guiding device, in particular in a rear rail section of a telescopic rail, comprising attachment means (11, 21a, 21b, 26, 28) for attaching the positioning device on a rear section of the movable furniture part, characterised in that the positioning device comprises an assembly element (6, 16a - 16c, 23, 24, 27), by means of which the positioning device can be attached detachably onto a first assembly position on the guiding device such that during the assembly of the furniture part at least a part of the attachment means (11, 21a, 21b, 26, 28) can be connected to the furniture part before a predefined force is reached, wherein the assembly element (6, 16a - 16c, 23, 24, 27) is released from the first assembly position, when the furniture part during the assembly on the guiding device is moved further in a predefined direction by at least the predetermined force, in that a separating area is predefined at a connection (7, 16a) of the assembly element (6, 16a - 16c, 23, 24, 27) to the positioning device.
A method for detecting a T cell dependent bispecific antibody in a composition, wherein the bispecific antibody comprises a target antigen binding fragment and a CD3 binding fragment, the method comprising contacting a population of T cells and target cells with the composition, wherein the T cells comprise nucleic acid encoding a reporter operably linked to a response element that is responsive to T cell activation, wherein the response element that is responsive to T cell activation is an NFκB promoter, optionally, wherein the response element that is responsive to T cell activation comprises T cell activation responsive elements from NFκB and wherein the target cells express the target antigen; wherein expression of the reporter indicates the presence of TDBs. contacting a population of T cells and target cells with the composition, wherein the T cells comprise nucleic acid encoding a reporter operably linked to a response element that is responsive to T cell activation, wherein the response element that is responsive to T cell activation is an NFκB promoter, optionally, wherein the response element that is responsive to T cell activation comprises T cell activation responsive elements from NFκB and wherein the target cells express the target antigen; wherein expression of the reporter indicates the presence of TDBs.
An article comprising: a substrate with a first major surface and a second major surface; an adhesive layer with a first major surface and a second major surface, wherein the first major surface of the adhesive layer is contacting the second major surface of the substrate, wherein the adhesive layer comprises a mixture of adhesive components, and wherein the adhesive components have the same chemical composition but different topological properties; and a liner with a first major surface and a second major surface, wherein the first major surface of the liner is contacting the second major surface of the adhesive layer, wherein the second major surface of the liner contains a plurality of concave structures that correspond to a plurality of concave structures in the adhesive layer, wherein the concave structures do not distort the second major surface of the substrate, and wherein the adhesive layer comprises a plurality of convex structures adjacent to the concave structures, wherein the adhesive components of the convex structures are permanent structures and have a different topological property from the concave structures, wherein the difference in topological properties of the adhesive components comprises a difference in viscoelastic response, such that the concave structures are unstable upon removal of the liner and the convex structures are not unstable upon removal of the liner, as measured by a Wet Out Fraction test as described in the description. a substrate with a first major surface and a second major surface; an adhesive layer with a first major surface and a second major surface, wherein the first major surface of the adhesive layer is contacting the second major surface of the substrate, wherein the adhesive layer comprises a mixture of adhesive components, and wherein the adhesive components have the same chemical composition but different topological properties; and a liner with a first major surface and a second major surface, wherein the first major surface of the liner is contacting the second major surface of the adhesive layer, wherein the second major surface of the liner contains a plurality of concave structures that correspond to a plurality of concave structures in the adhesive layer, wherein the concave structures do not distort the second major surface of the substrate, and wherein the adhesive layer comprises a plurality of convex structures adjacent to the concave structures, wherein the adhesive components of the convex structures are permanent structures and have a different topological property from the concave structures, wherein the difference in topological properties of the adhesive components comprises a difference in viscoelastic response, such that the concave structures are unstable upon removal of the liner and the convex structures are not unstable upon removal of the liner, as measured by a Wet Out Fraction test as described in the description.
A method for the diagnosis or prognosis of a disease characterized by a solid tumor comprising: determining the difference between a basal level or state of a class of proteins in a cell sample and the level or state of the proteins after contacting a portion of the sample with a modulator ex vivo within a cartridge in an automated system to evoke functional signalling profiles and fixing the cells, wherein the difference is expressed as a value used to create functional signaling profiles that stratify the samples into functional groups by a computer which is indicative of the presence, absence or risk of having a disease or which is indicative of the prognosis, and wherein the protein is modified by post translational modification which is phosphorylation. determining the difference between a basal level or state of a class of proteins in a cell sample and the level or state of the proteins after contacting a portion of the sample with a modulator ex vivo within a cartridge in an automated system to evoke functional signalling profiles and fixing the cells, wherein the difference is expressed as a value used to create functional signaling profiles that stratify the samples into functional groups by a computer which is indicative of the presence, absence or risk of having a disease or which is indicative of the prognosis, and wherein the protein is modified by post translational modification which is phosphorylation.
A gel-electrophoresis method, the method comprising (a) pre-staining a protein sample using a protocol comprising the steps of incubating the protein sample with a non-sterically hindered pyrylium dye for labeling the protein in the presence of a buffer, a detergent and a denaturing agent; and (b) electrophoresing the sample comprising the labeled protein on a gel. (a) pre-staining a protein sample using a protocol comprising the steps of incubating the protein sample with a non-sterically hindered pyrylium dye for labeling the protein in the presence of a buffer, a detergent and a denaturing agent; and (b) electrophoresing the sample comprising the labeled protein on a gel.
A lithium-ion battery, comprising: an anode; a cathode; a solid electrolyte layer positioned between the anode and the cathode; and a first protective layer continuously coating a cathode facing side of the solid electrolyte layer, the first protective layer formed on the cathode facing side in such a manner that a space within the solid electrolyte layer opening to the cathode facing side is filled with a first protective layer finger extending at least partially through the electrolyte layer, wherein the anode includes a form of lithium; the cathode includes a form of sulfur; and the first protective layer comprises Al 2 O 3 or Si 3 N 4. an anode; a cathode; a solid electrolyte layer positioned between the anode and the cathode; and a first protective layer continuously coating a cathode facing side of the solid electrolyte layer, the first protective layer formed on the cathode facing side in such a manner that a space within the solid electrolyte layer opening to the cathode facing side is filled with a first protective layer finger extending at least partially through the electrolyte layer,