A compound for use in the increase of insulin sensitivity, treatment of reduced insulin sensitivity and/or for use in the prevention of insulin resistance, wherein said compound is a compound according to Formula I, or pharmaceutically acceptable salt thereof,: wherein: R 1 is selected from the group consisting of hydrogen, -(C 1 -C 8)alkyl, -(C 1 -C 8)alkenyl, -(C 1 -C 8)alkynyl, unsubstituted or substituted -ara(C 1 -C 6)alkyl, unsubstituted or substituted -heteroara(C 1 -C 6)alkyl, where the substituents on said substituted ara(C 1 -C 6)alkyl and substituted heteroara(C 1 -C 6)alkyl are selected from the group consisting of halogen, -CN, - NO 2,- NH 2, -NH(C 1 -C 6)alkyl, -N[(C 1 -C 6)alkyl)] 2, -OH, halo(C 1 -C 6)alkyl, -(C 1 -C 6)alkoxy, halo(C 1 -C 6)alkoxy, -SH, thio(C 1 -C 6)alkyl, -SONH 2, -SO 2 NH 2, -SO-(C 1 -C 6)alkyl, -SO 2 -(C 1 -C 6)alkyl, -NHSO 2 (C 1 -C 6)alkyl, and -NHSO 2 NH 2; R 2 is selected from the group consisting of hydrogen, -(C 1 -C 8)alkyl, -(C 1 -C 8)alkenyl, -(C 1 -C 8)alkynyl, unsubstituted or substituted -ara(C 1 -C 6)alkyl, unsubstituted or substituted -heteroara(C 1 -C 6)alkyl, where the substituents on said substituted ara(C 1 -C 6)alkyl and substituted heteroara(C 1 -C 6)alkyl are selected from the group consisting of halogen, -CN, - NO 2,- NH 2, -OH, halo(C 1 -C 6)alkyl, -(C 1 -C 6)alkoxy, halo(C 1 -C 6)alkoxy, -SH, thio(C 1 -C 6)alkyl, -SONH 2, -SO 2 NH 2, -SO-(C 1 -C 6)alkyl, -SO 2 -(C 1 -C 6)alkyl, -NHSO 2 (C 1 -C 6)alkyl, and -NHSO 2 NH 2; R 3, R 4, R 7, R 8, R 9, R 10, R 13 and R 14 are independently selected from the group consisting of hydrogen and -(C 1 -C 6)alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, -(C 1 -C 6)alkyl and -OH, provided that both R 5 and R 6 cannot be -OH; R 11 and R 12 are independently selected from the group consisting of hydrogen, -(C 1 -C 6)alkyl and -OH, provided that both R 11 and R 12 cannot be -OH; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; o is 0, 1, 2, 3 or 4; p is 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; and r is 0, 1, 2, 3 or 4. R 1 is selected from the group consisting of hydrogen, -(C 1 -C 8)alkyl, -(C 1 -C 8)alkenyl, -(C 1 -C 8)alkynyl, unsubstituted or substituted -ara(C 1 -C 6)alkyl, unsubstituted or substituted -heteroara(C 1 -C 6)alkyl, where the substituents on said substituted ara(C 1 -C 6)alkyl and substituted heteroara(C 1 -C 6)alkyl are selected from the group consisting of halogen, -CN, - NO 2,- NH 2, -NH(C 1 -C 6)alkyl, -N[(C 1 -C 6)alkyl)] 2, -OH, halo(C 1 -C 6)alkyl, -(C 1 -C 6)alkoxy, halo(C 1 -C 6)alkoxy, -SH, thio(C 1 -C 6)alkyl, -SONH 2, -SO 2 NH 2, -SO-(C 1 -C 6)alkyl, -SO 2 -(C 1 -C 6)alkyl, -NHSO 2 (C 1 -C 6)alkyl, and -NHSO 2 NH 2; R 2 is selected from the group consisting of hydrogen, -(C 1 -C 8)alkyl, -(C 1 -C 8)alkenyl, -(C 1 -C 8)alkynyl, unsubstituted or substituted -ara(C 1 -C 6)alkyl, unsubstituted or substituted -heteroara(C 1 -C 6)alkyl, where the substituents on said substituted ara(C 1 -C 6)alkyl and substituted heteroara(C 1 -C 6)alkyl are selected from the group consisting of halogen, -CN, - NO 2,- NH 2, -OH, halo(C 1 -C 6)alkyl, -(C 1 -C 6)alkoxy, halo(C 1 -C 6)alkoxy, -SH, thio(C 1 -C 6)alkyl, -SONH 2, -SO 2 NH 2, -SO-(C 1 -C 6)alkyl, -SO 2 -(C 1 -C 6)alkyl, -NHSO 2 (C 1 -C 6)alkyl, and -NHSO 2 NH 2; R 3, R 4, R 7, R 8, R 9, R 10, R 13 and R 14 are independently selected from the group consisting of hydrogen and -(C 1 -C 6)alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, -(C 1 -C 6)alkyl and -OH, provided that both R 5 and R 6 cannot be -OH; R 11 and R 12 are independently selected from the group consisting of hydrogen, -(C 1 -C 6)alkyl and -OH, provided that both R 11 and R 12 cannot be -OH; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; o is 0, 1, 2, 3 or 4; p is 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; and r is 0, 1, 2, 3 or 4.