A recombinant chimeric virus comprising: a first nucleic acid molecule comprising: a 5' non-coding region from a dengue type 4 virus; a nucleic acid encoding: a C protein from a dengue type 4 virus; and non-structural proteins from a dengue type 4 virus, wherein nonstructural protein NS4B comprises a phenylalanine at amino acid position 112 corresponding to amino acid position 2359 of SEQ ID NO: 2, and nonstructural protein NS5 comprises an alanine at amino acid position 654 corresponding to amino acid position 3146 of SEQ ID NO: 2 and an alanine at amino acid position 655 corresponding to amino acid position 3147 of SEQ ID NO: 2; and a 3' non-coding region from a dengue type 4 virus, wherein the 3' non-coding region comprises a deletion corresponding to nucleotides 10478-10507 of the wild type dengue type 4 virus; and a second nucleic acid molecule operably linked to the first nucleic acid molecule, the second nucleic acid molecule encoding: a prM protein from a tick borne encephalitis virus; and an E protein from a tick borne encephalitis virus, wherein the E protein comprises an aspartic acid at amino acid position 315 corresponding to amino acid position 598 of SEQ ID NO: 2 and a tryptophan at amino acid position 240 corresponding to amino acid position 523 of SEQ ID NO: 2. a first nucleic acid molecule comprising: a 5' non-coding region from a dengue type 4 virus; a nucleic acid encoding: a C protein from a dengue type 4 virus; and non-structural proteins from a dengue type 4 virus, wherein nonstructural protein NS4B comprises a phenylalanine at amino acid position 112 corresponding to amino acid position 2359 of SEQ ID NO: 2, and nonstructural protein NS5 comprises an alanine at amino acid position 654 corresponding to amino acid position 3146 of SEQ ID NO: 2 and an alanine at amino acid position 655 corresponding to amino acid position 3147 of SEQ ID NO: 2; and a 3' non-coding region from a dengue type 4 virus, wherein the 3' non-coding region comprises a deletion corresponding to nucleotides 10478-10507 of the wild type dengue type 4 virus; and a 5' non-coding region from a dengue type 4 virus; a nucleic acid encoding: a C protein from a dengue type 4 virus; and non-structural proteins from a dengue type 4 virus, wherein nonstructural protein NS4B comprises a phenylalanine at amino acid position 112 corresponding to amino acid position 2359 of SEQ ID NO: 2, and nonstructural protein NS5 comprises an alanine at amino acid position 654 corresponding to amino acid position 3146 of SEQ ID NO: 2 and an alanine at amino acid position 655 corresponding to amino acid position 3147 of SEQ ID NO: 2; and a C protein from a dengue type 4 virus; and non-structural proteins from a dengue type 4 virus, wherein nonstructural protein NS4B comprises a phenylalanine at amino acid position 112 corresponding to amino acid position 2359 of SEQ ID NO: 2, and nonstructural protein NS5 comprises an alanine at amino acid position 654 corresponding to amino acid position 3146 of SEQ ID NO: 2 and an alanine at amino acid position 655 corresponding to amino acid position 3147 of SEQ ID NO: 2; and a 3' non-coding region from a dengue type 4 virus, wherein the 3' non-coding region comprises a deletion corresponding to nucleotides 10478-10507 of the wild type dengue type 4 virus; and a second nucleic acid molecule operably linked to the first nucleic acid molecule, the second nucleic acid molecule encoding: a prM protein from a tick borne encephalitis virus; and an E protein from a tick borne encephalitis virus, wherein the E protein comprises an aspartic acid at amino acid position 315 corresponding to amino acid position 598 of SEQ ID NO: 2 and a tryptophan at amino acid position 240 corresponding to amino acid position 523 of SEQ ID NO: 2. a prM protein from a tick borne encephalitis virus; and an E protein from a tick borne encephalitis virus, wherein the E protein comprises an aspartic acid at amino acid position 315 corresponding to amino acid position 598 of SEQ ID NO: 2 and a tryptophan at amino acid position 240 corresponding to amino acid position 523 of SEQ ID NO: 2.