System for removing a pipettable substance from a pre-filled container which is closed by a top that has at least one opening area, comprising - an opening tool, comprising (i) a plurality of tubes which are arranged in an m x n matrix and connected by an element, the tubes having a cross-section substantially corresponding to the shape of the opening area and at a distal end an endpiece extending substantially at an angle relative to the longitudinal axis of the tube, which moves a part of the top located inside the opening area toward the container when the opening tool is applied so as to make an opening in the top, wherein the inclined endpiece of the tube has a point at its distal end and has at least two different angles α relative to the longitudinal axis of the tube over the area from its dorsal end to its distal end, and wherein a spatial direction defined by a perpendicular to the main plane of the inclined endpiece of the tube is different in at least two of the tubes, (ii) a point of attack for a transporting tool, the opening tool being configured to remain at the container after use, - a transporting tool for moving the opening tool through the top, - a pipetting tool which is adapted to be inserted over at least part of its length through the tube into the interior of the container, in the state of use of the opening tool, and one end of which can be connected to a suction device for sucking a pipettable substance out of the interior of the container. - an opening tool, comprising (i) a plurality of tubes which are arranged in an m x n matrix and connected by an element, the tubes having a cross-section substantially corresponding to the shape of the opening area and at a distal end an endpiece extending substantially at an angle relative to the longitudinal axis of the tube, which moves a part of the top located inside the opening area toward the container when the opening tool is applied so as to make an opening in the top, wherein the inclined endpiece of the tube has a point at its distal end and has at least two different angles α relative to the longitudinal axis of the tube over the area from its dorsal end to its distal end, and wherein a spatial direction defined by a perpendicular to the main plane of the inclined endpiece of the tube is different in at least two of the tubes, (ii) a point of attack for a transporting tool, the opening tool being configured to remain at the container after use, - a transporting tool for moving the opening tool through the top, - a pipetting tool which is adapted to be inserted over at least part of its length through the tube into the interior of the container, in the state of use of the opening tool, and one end of which can be connected to a suction device for sucking a pipettable substance out of the interior of the container. (i) a plurality of tubes which are arranged in an m x n matrix and connected by an element, the tubes having a cross-section substantially corresponding to the shape of the opening area and at a distal end an endpiece extending substantially at an angle relative to the longitudinal axis of the tube, which moves a part of the top located inside the opening area toward the container when the opening tool is applied so as to make an opening in the top, wherein the inclined endpiece of the tube has a point at its distal end and has at least two different angles α relative to the longitudinal axis of the tube over the area from its dorsal end to its distal end, and wherein a spatial direction defined by a perpendicular to the main plane of the inclined endpiece of the tube is different in at least two of the tubes, (ii) a point of attack for a transporting tool, the opening tool being configured to remain at the container after use, - a transporting tool for moving the opening tool through the top, - a pipetting tool which is adapted to be inserted over at least part of its length through the tube into the interior of the container, in the state of use of the opening tool, and one end of which can be connected to a suction device for sucking a pipettable substance out of the interior of the container. - a transporting tool for moving the opening tool through the top, - a pipetting tool which is adapted to be inserted over at least part of its length through the tube into the interior of the container, in the state of use of the opening tool, and one end of which can be connected to a suction device for sucking a pipettable substance out of the interior of the container.