A pneumatic tire comprising: a tread portion having an inboard tread edge (Tel) to be positioned towards the center of a vehicle body, and an outboard tread edge to be positioned away from the center of the vehicle body, the tread portion provided with an inboard shoulder main groove disposed on the inboard tread edge (Tel) side and extending continuously in the tire circumferential direction, an outboard shoulder main groove disposed on the outboard tread edge side and extending continuously in the tire circumferential direction, and a center main groove disposed between the inboard shoulder main groove and the outboard shoulder main groove and extending continuously in the tire circumferential direction, so as to define an inboard shoulder land region axially outside the inboard shoulder main groove, and an inboard middle land region between the inboard shoulder main groove and the center main groove, a ratio W4/W3 of a width W4 in the tire axial direction of the inboard shoulder land region to a width W3 in the tire axial direction of the inboard middle land region is set in a range of from 1.3 to 1.4, the inboard shoulder land region is provided with a plurality of shoulder lateral grooves extending axially inwardly from the inboard tread edge to terminate within the inboard shoulder land region, and arranged circumferentially of the tire, wherein a groove width W1 of the inboard shoulder main groove is more than a groove width W2 of the outboard shoulder main groove, characterized in that the groove width W1 of the inboard shoulder main groove is in a range of from 9.0 % to 10.0 % of the tread width, and a ratio W5/P1 of a groove width W5 of the shoulder lateral grooves to an arrangement pitch P1 in the tire circumferential direction of the shoulder lateral grooves is in a range of from 0.18 to 0.25. a tread portion having an inboard tread edge (Tel) to be positioned towards the center of a vehicle body, and an outboard tread edge to be positioned away from the center of the vehicle body, the tread portion provided with an inboard shoulder main groove disposed on the inboard tread edge (Tel) side and extending continuously in the tire circumferential direction, an outboard shoulder main groove disposed on the outboard tread edge side and extending continuously in the tire circumferential direction, and a center main groove disposed between the inboard shoulder main groove and the outboard shoulder main groove and extending continuously in the tire circumferential direction, so as to define an inboard shoulder land region axially outside the inboard shoulder main groove, and an inboard middle land region between the inboard shoulder main groove and the center main groove, a ratio W4/W3 of a width W4 in the tire axial direction of the inboard shoulder land region to a width W3 in the tire axial direction of the inboard middle land region is set in a range of from 1.3 to 1.4, the inboard shoulder land region is provided with a plurality of shoulder lateral grooves extending axially inwardly from the inboard tread edge to terminate within the inboard shoulder land region, and arranged circumferentially of the tire, wherein a groove width W1 of the inboard shoulder main groove is more than a groove width W2 of the outboard shoulder main groove, the groove width W1 of the inboard shoulder main groove is in a range of from 9.0 % to 10.0 % of the tread width, and a ratio W5/P1 of a groove width W5 of the shoulder lateral grooves to an arrangement pitch P1 in the tire circumferential direction of the shoulder lateral grooves is in a range of from 0.18 to 0.25.