An assembly (12; 112; 312; 412; 412'; 512; 612; 712) for use with a syringe (10; 110; 210; 310; 410; 510; 610; 710) having a barrel (14; 214; 414; 614; 714) and a needle (16; 116; 216, 316; 416; 516; 616; 716) extending from a distal end (11; 311; 411; 611; 711) thereof, the assembly (12; 112; 212; 312; 412; 512; 612; 712) comprising: an adapter (20; 120; 220; 320; 420; 520; 620; 720) positioned over the distal end (11; 311; 411; 611; 711) of the syringe (10; 110; 210; 310; 410; 510; 610; 710), the adapter (20; 120; 220; 320; 420; 520; 620; 720) including: a first skin contacting surface (22; 122; 322; 522) positioned at a distal end of the adapter (20; 120; 220; 320; 420; 520; 620; 720), at least a portion of the first skin contacting surface (22; 122; 322; 522) extending generally parallel to at least a terminal end of the needle (16; 116; 216; 316; 416; 516; 616; 716), and a second skin contacting surface (24; 324) positioned proximally relative to the terminal end of the needle (16; 116; 216, 316; 416; 516; 616; 716) and at an angle to the first skin contacting surface (22; 122; 322; 522); and a needle shield (26; 126; 226; 326; 426; 526; 626; 726) at least partially surrounding and removably positioned over at least one of the adapter (20; 120; 220; 320; 420; 520; 620; 720), the sealing element (18; 118; 318; 418; 518; 618; 718), and the syringe barrel (14; 214; 414; 614; 714), characterized by a sealing element (18; 118; 318; 418; 518; 618; 718) surrounding and positioned over at least a portion of the distal end (11; 311; 411; 611; 711) of the syringe (10; 110; 210; 310; 410; 510; 610; 710) and wherein the adapter (20; 120; 220; 320; 420; 520; 620; 720) at least partially surrounds the sealing element (18; 118; 318; 418; 518; 618; 718). an adapter (20; 120; 220; 320; 420; 520; 620; 720) positioned over the distal end (11; 311; 411; 611; 711) of the syringe (10; 110; 210; 310; 410; 510; 610; 710), the adapter (20; 120; 220; 320; 420; 520; 620; 720) including: a first skin contacting surface (22; 122; 322; 522) positioned at a distal end of the adapter (20; 120; 220; 320; 420; 520; 620; 720), at least a portion of the first skin contacting surface (22; 122; 322; 522) extending generally parallel to at least a terminal end of the needle (16; 116; 216; 316; 416; 516; 616; 716), and a second skin contacting surface (24; 324) positioned proximally relative to the terminal end of the needle (16; 116; 216, 316; 416; 516; 616; 716) and at an angle to the first skin contacting surface (22; 122; 322; 522); and a needle shield (26; 126; 226; 326; 426; 526; 626; 726) at least partially surrounding and removably positioned over at least one of the adapter (20; 120; 220; 320; 420; 520; 620; 720), the sealing element (18; 118; 318; 418; 518; 618; 718), and the syringe barrel (14; 214; 414; 614; 714), a first skin contacting surface (22; 122; 322; 522) positioned at a distal end of the adapter (20; 120; 220; 320; 420; 520; 620; 720), at least a portion of the first skin contacting surface (22; 122; 322; 522) extending generally parallel to at least a terminal end of the needle (16; 116; 216; 316; 416; 516; 616; 716), and a second skin contacting surface (24; 324) positioned proximally relative to the terminal end of the needle (16; 116; 216, 316; 416; 516; 616; 716) and at an angle to the first skin contacting surface (22; 122; 322; 522); and a needle shield (26; 126; 226; 326; 426; 526; 626; 726) at least partially surrounding and removably positioned over at least one of the adapter (20; 120; 220; 320; 420; 520; 620; 720), the sealing element (18; 118; 318; 418; 518; 618; 718), and the syringe barrel (14; 214; 414; 614; 714),