A titration support system for a positive air pressure, PAP, device, the system comprising: at least one controller (120, 190, 194); an external sensor comprising at least an electrical impedance tomography, EIT, sensor, the external sensor configured to: determine whether the EIT sensor is coupled to skin of a user; establish communication with the at least one controller (120, 190, 194) in response to determining that the external sensor is coupled to the skin of the user; sense a physiological parameter of the user and form corresponding sensor information; determine whether cardiac output is diminished based upon the sensor information; and transmit the sensor information including an indication of whether the cardiac output is diminished to the at least one controller (120, 190, 194); the at least one controller (120, 190, 194) configured to: control a flow generator to provide therapeutic air assist to the user; receive the sensor information from the external sensor; determine whether the sensor information comprises the indication that the cardiac output is diminished; begin auto titration to restore the cardiac output to homeopathic levels in response to determining that the cardiac output is diminished; identify a pressure sensitivity of the user based on trending of the cardiac output mapped as a function on a control parameter of the PAP device; and control the PAP device to adapt PAP therapy based on the pressure sensitivity. at least one controller (120, 190, 194); an external sensor comprising at least an electrical impedance tomography, EIT, sensor, the external sensor configured to: determine whether the EIT sensor is coupled to skin of a user; establish communication with the at least one controller (120, 190, 194) in response to determining that the external sensor is coupled to the skin of the user; sense a physiological parameter of the user and form corresponding sensor information; determine whether cardiac output is diminished based upon the sensor information; and transmit the sensor information including an indication of whether the cardiac output is diminished to the at least one controller (120, 190, 194); determine whether the EIT sensor is coupled to skin of a user; establish communication with the at least one controller (120, 190, 194) in response to determining that the external sensor is coupled to the skin of the user; sense a physiological parameter of the user and form corresponding sensor information; determine whether cardiac output is diminished based upon the sensor information; and transmit the sensor information including an indication of whether the cardiac output is diminished to the at least one controller (120, 190, 194); the at least one controller (120, 190, 194) configured to: control a flow generator to provide therapeutic air assist to the user; receive the sensor information from the external sensor; determine whether the sensor information comprises the indication that the cardiac output is diminished; begin auto titration to restore the cardiac output to homeopathic levels in response to determining that the cardiac output is diminished; identify a pressure sensitivity of the user based on trending of the cardiac output mapped as a function on a control parameter of the PAP device; and control the PAP device to adapt PAP therapy based on the pressure sensitivity. control a flow generator to provide therapeutic air assist to the user; receive the sensor information from the external sensor; determine whether the sensor information comprises the indication that the cardiac output is diminished; begin auto titration to restore the cardiac output to homeopathic levels in response to determining that the cardiac output is diminished; identify a pressure sensitivity of the user based on trending of the cardiac output mapped as a function on a control parameter of the PAP device; and control the PAP device to adapt PAP therapy based on the pressure sensitivity.