mhurhangee/ep-ind-claims huggingface dataset:
A method for producing a chimeric antigen receptor comprising at least one antigen specific targeting region, a transmembrane domain and an intracellular signaling domain, said method comprising the steps of generating the at least one antigen specific targeting region that binds to a target antigen located on a surface of cancer cells from a parent protein or a domain thereof that binds specifically with the target antigen located on the surface of the cancer cells, by: i. evolving the DNA which encodes the parent protein or a domain thereof using one or more evolutionary techniques to create mutant DNAs; ii. expressing the mutant DNAs to obtain mutant polypeptides; iii. subjecting the mutant polypeptides to an assay under a normal physiological pH and to an assay under an aberrant pH; iv. selecting a conditionally active antigen specific targeting region from the mutant polypeptides expressed in step (iii) which exhibits a decrease in activity in binding to the target antigen located on a surface of cancer cells in the assay at the normal physiological pH compared to the same activity in binding to the target antigen located on a surface of cancer cells in the assay under the aberrant pH, and v. linking the at least one antigen specific targeting region, the transmembrane domain and the intracellular signaling domain to produce the chimeric antigen receptor; and wherein the target antigen is a tyrosine kinase growth factor receptor which is overexpressed on the surface of the cancer cells. i. evolving the DNA which encodes the parent protein or a domain thereof using one or more evolutionary techniques to create mutant DNAs; ii. expressing the mutant DNAs to obtain mutant polypeptides; iii. subjecting the mutant polypeptides to an assay under a normal physiological pH and to an assay under an aberrant pH; iv. selecting a conditionally active antigen specific targeting region from the mutant polypeptides expressed in step (iii) which exhibits a decrease in activity in binding to the target antigen located on a surface of cancer cells in the assay at the normal physiological pH compared to the same activity in binding to the target antigen located on a surface of cancer cells in the assay under the aberrant pH, and v. linking the at least one antigen specific targeting region, the transmembrane domain and the intracellular signaling domain to produce the chimeric antigen receptor; and
An atomic oscillator (1000; 2000; 3000) comprising: a gas cell having alkali metal atoms sealed therein; a light source that irradiates the gas cell with light; and a light detecting unit that detects the quantity of light transmitted through the gas cell, wherein the light source includes, an optical oscillation layer having a first reflective layer, an active layer, and a second reflective layer laminated therein in this order, characterised in that the light source further includes: an electrical field absorption layer having a first semiconductor layer, a quantum well layer, and a second semiconductor layer laminated therein in this order, and a heat diffusion layer that is disposed between the optical oscillation layer and the electrical field absorption layer and has a higher thermal conductivity than that of the second reflective layer. a gas cell having alkali metal atoms sealed therein; a light source that irradiates the gas cell with light; and a light detecting unit that detects the quantity of light transmitted through the gas cell, wherein the light source includes, an optical oscillation layer having a first reflective layer, an active layer, and a second reflective layer laminated therein in this order, characterised in that the light source further includes: an electrical field absorption layer having a first semiconductor layer, a quantum well layer, and a second semiconductor layer laminated therein in this order, and a heat diffusion layer that is disposed between the optical oscillation layer and the electrical field absorption layer and has a higher thermal conductivity than that of the second reflective layer. an electrical field absorption layer having a first semiconductor layer, a quantum well layer, and a second semiconductor layer laminated therein in this order, and a heat diffusion layer that is disposed between the optical oscillation layer and the electrical field absorption layer and has a higher thermal conductivity than that of the second reflective layer.
A compound containing - a hydrophobic wax; - a silicone oil containing exclusively hydrocarbyl side chains; and - a hydrophilic binding agent - pigments and/or fillers wherein the compound has - a pigment volume concentration of 25 to 60 % according to EN ISO 4618-1 (wherein the quantity is relative to the total of all pigments and fillers); wherein "hydrophobic" means that the initial static contact angle with water after 3 minutes' equilibration time is >90°; "hydrophilic" means that the initial static contact angle with water after 3 minutes' equilibration time is ≤90°. - a hydrophobic wax; - a silicone oil containing exclusively hydrocarbyl side chains; and - a hydrophilic binding agent - pigments and/or fillers - a pigment volume concentration of 25 to 60 % according to EN ISO 4618-1 (wherein the quantity is relative to the total of all pigments and fillers);
A method for optimizing component type arrangement in which a plurality of component types (P1 to P9, P11 to P15) of components are optimally disposed on a plurality of installation positions (SL1 to SL9) when an automatic feeder device which has an automatic loading function of automatically loading a component storage tape in which the components are each stored in a plurality of component storage sections if the component storage tape is inserted into the automatic feeder device, a manual feeder device which does not have the automatic loading function, and a reel holding device which rotatably holds a component supply reel (85, 86) around which the component storage tape is wound are installed in the plurality of installation positions (SL1 to SL9) which are set to be arrayed on a common pallet equipped in a component mounting machine, the method comprising: a fixing setting step of determining a portion of the plurality of installation positions (SL1 to SL9) as a fixed position and setting so as to install the automatic feeder device to the fixed position; and an optimizing step of performing a simulation for optimally disposing the plurality of component types (P1 to P9, P11 to P15) of the components on the plurality of installation positions (SL1 to SL9) under a condition that the manual feeder device can be moved to an arbitrary installation position (SL1 to SL9) other than the fixed position without moving the automatic feeder device from the fixed position; characterized in that: the specific reel holding device rotatably holds the plurality of component supply reels (85, 86) around which the component storage tapes used in a plurality of specific automatic feeder devices are wound respectively, and wherein, in the fixing setting step, a setting is made so that the plurality of specific automatic feeder devices are collectively installed in a continuous range of the plurality of installation positions (SL1 to SL9). a fixing setting step of determining a portion of the plurality of installation positions (SL1 to SL9) as a fixed position and setting so as to install the automatic feeder device to the fixed position; and an optimizing step of performing a simulation for optimally disposing the plurality of component types (P1 to P9, P11 to P15) of the components on the plurality of installation positions (SL1 to SL9) under a condition that the manual feeder device can be moved to an arbitrary installation position (SL1 to SL9) other than the fixed position without moving the automatic feeder device from the fixed position; the specific reel holding device rotatably holds the plurality of component supply reels (85, 86) around which the component storage tapes used in a plurality of specific automatic feeder devices are wound respectively, and wherein, in the fixing setting step, a setting is made so that the plurality of specific automatic feeder devices are collectively installed in a continuous range of the plurality of installation positions (SL1 to SL9).
A non-oriented electrical steel sheet having a chemical composition comprising: C: 0 to 0.0050 mass%, Si: 0.50 to 2.70 mass%, Mn: 0.10 to 3.00 mass%, Al: 1.00 to 2.70 mass%, P: 0.050 to 0.100 mass%, S: 0 to 0.0060 mass%, N: 0 to 0.0050 mass%, Ti: 0 to 0.008 mass%, V: 0 to 0.008 mass%, Nb: 0 to 0.008 mass%, Zr: 0 to 0.008 mass%, and a balance: Fe and impurities, wherein the chemical composition satisfies a following expression, a following expression, and a following expression, an intensity of a plane I and an intensity of a plane I satisfy a following expression, the intensity I and the intensity I being determined by calculating an average of an orientation determination function near a surface and an orientation determination function at a thickness center using pole figures measured by an X-ray diffraction method, a specific resistance is 60.0×10 -8 Ω·m or higher at room temperature, a thickness is 0.05 mm to 0.40 mm, 0.50 ≤ Al / Si + Al + 0.5 × Mn ≤ 0.83 1.28 ≤ Si + Al / 2 + Mn / 4 + 5 × P ≤ 3.90 4.0 ≤ Si + Al + 0.5 × Mn ≤ 7.0 and 0.50 ≤ I 100 / I 111 ≤ 1.40 wherein in expressions to the chemical symbols indicate the amounts of the corresponding chemical elements in mass%. C: 0 to 0.0050 mass%, Si: 0.50 to 2.70 mass%, Mn: 0.10 to 3.00 mass%, Al: 1.00 to 2.70 mass%, P: 0.050 to 0.100 mass%, S: 0 to 0.0060 mass%, N: 0 to 0.0050 mass%, Ti: 0 to 0.008 mass%, V: 0 to 0.008 mass%, Nb: 0 to 0.008 mass%, Zr: 0 to 0.008 mass%, and a balance: Fe and impurities, wherein
A backup power source device comprising: a capacitor; a charging circuit provided in a charging path of the capacitor and performing step-down operation; a boost circuit provided in an output path of the capacitor; and a door-lock-releasing output terminal connected to the boost circuit, characterized in that the boost circuit has a switching element, a boost coil, and a discharge pattern disposed on a first side of a substrate, and the capacitor is disposed on a second side of the substrate, and series-connected to the switching element and the boost coil. a capacitor; a charging circuit provided in a charging path of the capacitor and performing step-down operation; a boost circuit provided in an output path of the capacitor; and a door-lock-releasing output terminal connected to the boost circuit, characterized in that the boost circuit has a switching element, a boost coil, and a discharge pattern disposed on a first side of a substrate, and the capacitor is disposed on a second side of the substrate, and series-connected to the switching element and the boost coil.
Combustion engine comprising: a turbine device with a first turbine wheel, arranged in an exhaust system of the combustion engine in a manner that it is operable by exhaust gas, a compressor device with a first compressor wheel, wherein gas, in particular air, compressed by the compressor device is at least partially conveyed to the turbine device, a shaft, which is coupled with the first turbine wheel and the first compressor wheel, and a heat exchanger (6a, 6b, 6c, 6d), which is thermally connected to the exhaust system in a manner that exhaust heat of exhaust gas of the combustion machine is conferred to the gas, in particular air, compressed by the compressor device which is conveyed to the turbine device, characterized in that the heat exchanger has a cross sectional area which increases with the direction of flow of the compressed gas in a manner that the macroscopical flow velocity of the compressed gas lies within a determined range of values along the entirety of the heat exchanger (6a, 6b, 6c, 6d). a turbine device with a first turbine wheel, arranged in an exhaust system of the combustion engine in a manner that it is operable by exhaust gas, a compressor device with a first compressor wheel, wherein gas, in particular air, compressed by the compressor device is at least partially conveyed to the turbine device, a shaft, which is coupled with the first turbine wheel and the first compressor wheel, and a heat exchanger (6a, 6b, 6c, 6d), which is thermally connected to the exhaust system in a manner that exhaust heat of exhaust gas of the combustion machine is conferred to the gas, in particular air, compressed by the compressor device which is conveyed to the turbine device, characterized in that the heat exchanger has a cross sectional area which increases with the direction of flow of the compressed gas in a manner that the macroscopical flow velocity of the compressed gas lies within a determined range of values along the entirety of the heat exchanger (6a, 6b, 6c, 6d).
An elastic primary dressing for moist wound care, in the form of a mesh or netting produced from elongate elastic elements, wherein the mesh or netting contains non-resorbable elongate elements, wherein the non-resorbable elongate elements consist of silicone and at least one additive selected from pharmacologically active ingredients, collagen, hydrocolloids and/or colorants.
Electrical installation device having a supporting ring for mounting on a connector socket, the supporting ring having four openings with a keyhole profile which lie opposite one another in pairs and are arranged around a through opening of the supporting ring, each opening comprising in each case one arcuate ring section, the arcuate ring sections which lie opposite one another being arranged concavely with respect to one another, the openings being spaced apart from the centre point of the ring sections by a radian measure of n/2, and all four ring sections having a circular section in each case at one arc end, the diameter of each circular section being greater than the radial thickness of its arcuate ring section, characterized in that, in the case of two openings which lie opposite one another, the circular sections are arranged in the clockwise direction at the arc ends of the ring sections, and in that, in the case of the other two openings which lie opposite one another, the circular sections are arranged counter to the clockwise direction at the arc ends of the ring sections.
A personal care composition being a hair care composition and comprising a polymer having the structure: wherein each Q is a hydrocarbyl moiety comprising at least one ether and at least one hydroxyl, and has a structure independently selected from the group consisting of: and combinations thereof, wherein each asterisk symbol ( ∗) denotes the point of attachment of said Q to the polymer backbone and each hash symbol (#) denotes the point(s) of attachment of said Q to said E group(s); each Q' is a hydrocarbyl moiety comprising at least one hydroxyl and optionally at least one ether; each E is independently selected from the group consisting of: and combinations thereof; each R 1 is a functionalized or unfunctionalized alkyl; each R 2, R 3 and R 4 is independently selected from the group consisting of hydrogen, functionalized and unfunctionalized alkyl, and combinations thereof; each A is an independently selected anion; n is an integer representing number of said E groups attached to said Q moiety, wherein said n ≥ 1; a is a value ranging from 0.1 to 100 percent by weight of said polymer; and each b, c, and d is an independently selected value ranging from 0 to 99.9 percent by weight of said polymer, with the proviso that sum of said a, b, c and d for each said polymer equals 100 weight percent. each Q' is a hydrocarbyl moiety comprising at least one hydroxyl and optionally at least one ether; each E is independently selected from the group consisting of: and combinations thereof; each R 1 is a functionalized or unfunctionalized alkyl; each R 2, R 3 and R 4 is independently selected from the group consisting of hydrogen, functionalized and unfunctionalized alkyl, and combinations thereof; each A is an independently selected anion; n is an integer representing number of said E groups attached to said Q moiety, wherein said n ≥ 1; a is a value ranging from 0.1 to 100 percent by weight of said polymer; and each b, c, and d is an independently selected value ranging from 0 to 99.9 percent by weight of said polymer, with the proviso that sum of said a, b, c and d for each said polymer equals 100 weight percent.
A connection structure of an aluminum cable and a terminal, comprising: an aluminum cable, comprising a cable core, wherein the cable core is constructed with a cable welding portion; and a terminal, welded to the cable welding portion, characterized in that a nominal cross-sectional area of the cable core is M, and a welding area S between the cable welding portion and the terminal meets 5*M≤S≤6*M. an aluminum cable, comprising a cable core, wherein the cable core is constructed with a cable welding portion; and a terminal, welded to the cable welding portion, characterized in that a nominal cross-sectional area of the cable core is M, and a welding area S between the cable welding portion and the terminal meets 5*M≤S≤6*M.
A process of manufacturing an article containing N-acylchitosan, the process comprising the steps of providing an N-acylchitosan hydrogel fixed in a desired shape, and at least partially drying the hydrogel under fixation of the desired shape, thereby forming an article with a fiber coil shape or a tubular shape with one or more sections shaped in a non-linear conformation with respect to the longitudinal axis of the tube.
Air vent with two first air guide elements which are upstream of an air outlet opening and a front section of an air channel of the air vent in air flow direction, wherein - the first air guide elements are so arranged that they reduce the cross-section of the air channel and - the pivot axes of the first air guide elements run through the ends, which are remote from the air outlet opening, of the first air guide elements, characterised in that the air vent comprises - a second air guide element, which is arranged in the front section of the air channel of the air vent, wherein the front section has opposite curved housing walls, and - a slat arrangement with a first group of slats and a second group of slats, wherein the first group of slats and the second group of slats are each pivotably mounted between the second air guide element and an opposite housing wall. - the first air guide elements are so arranged that they reduce the cross-section of the air channel and - the pivot axes of the first air guide elements run through the ends, which are remote from the air outlet opening, of the first air guide elements, characterised in that the air vent comprises - a second air guide element, which is arranged in the front section of the air channel of the air vent, wherein the front section has opposite curved housing walls, and - a slat arrangement with a first group of slats and a second group of slats, wherein the first group of slats and the second group of slats are each pivotably mounted between the second air guide element and an opposite housing wall.
An automotive air conditioning system, comprising a compressor, a first heat exchanger, a second heat exchanger, a first pump, a first combined valve, a second combined valve and an outdoor heat exchanger; wherein the automotive air conditioning system further comprises a first cooling mechanism and a first heating mechanism; wherein the compressor, the outdoor heat exchanger, the first combined valve and the second heat exchanger are communicated in sequence to form a circuit under the first cooling mechanism, wherein the first pump, the second heat exchanger and the first heat exchanger are communicated in sequence to form a circuit; wherein the compressor, the second heat exchanger, the second combination valve and the outdoor heat exchanger are communicated in sequence to form a circuit under the first heating mechanism, wherein the first pump, the second heat exchanger and a first heat exchanger are communicated in sequence to form a circuit; wherein the automotive air conditioning system further comprises a circulating liquid circuit with a fourth heat exchanger therein; wherein the automotive air conditioning system further comprises a box in which the first heat exchanger and the fourth heat exchanger are disposed; characterized in that, the circulating liquid circuit further comprises a heater, a battery unit, a third heat exchanger being a liquid heat exchanger and a second pump; and the automotive air conditioning system further comprises a second heating mechanism under which the third heat exchanger, the second pump, the heater and the battery unit are communicated in sequence to form a circuit. wherein the automotive air conditioning system further comprises a first cooling mechanism and a first heating mechanism; wherein the compressor, the outdoor heat exchanger, the first combined valve and the second heat exchanger are communicated in sequence to form a circuit under the first cooling mechanism, wherein the first pump, the second heat exchanger and the first heat exchanger are communicated in sequence to form a circuit; wherein the compressor, the second heat exchanger, the second combination valve and the outdoor heat exchanger are communicated in sequence to form a circuit under the first heating mechanism, wherein the first pump, the second heat exchanger and a first heat exchanger are communicated in sequence to form a circuit; wherein the automotive air conditioning system further comprises a circulating liquid circuit with a fourth heat exchanger therein; wherein the automotive air conditioning system further comprises a box in which the first heat exchanger and the fourth heat exchanger are disposed; characterized in that, the circulating liquid circuit further comprises a heater, a battery unit, a third heat exchanger being a liquid heat exchanger and a second pump; and the automotive air conditioning system further comprises a second heating mechanism under which the third heat exchanger, the second pump, the heater and the battery unit are communicated in sequence to form a circuit.
A processing system comprising: at least two cores (1100, 2100, 2200), each core having a local cache (2110, 3110); a lower level cache in communication with each local cache; one local cache configured to: request a cache line to execute an atomic memory operation instruction; receive the cache line via the lower level cache, wherein the lower level cache is configured to determine availability of the cache line based on input from other caches or memory structures associated with the cache line; receive a probe downgrade due to other local cache requesting the cache line prior to execution of the AMO; and send the AMO instruction to the lower level cache for remote execution in response to the probe downgrade. at least two cores (1100, 2100, 2200), each core having a local cache (2110, 3110); a lower level cache in communication with each local cache; one local cache configured to: request a cache line to execute an atomic memory operation instruction; receive the cache line via the lower level cache, wherein the lower level cache is configured to determine availability of the cache line based on input from other caches or memory structures associated with the cache line; receive a probe downgrade due to other local cache requesting the cache line prior to execution of the AMO; and send the AMO instruction to the lower level cache for remote execution in response to the probe downgrade. request a cache line to execute an atomic memory operation instruction; receive the cache line via the lower level cache, wherein the lower level cache is configured to determine availability of the cache line based on input from other caches or memory structures associated with the cache line; receive a probe downgrade due to other local cache requesting the cache line prior to execution of the AMO; and send the AMO instruction to the lower level cache for remote execution in response to the probe downgrade.