A compound of Formula or Formula II or a pharmaceutically acceptable salt thereof, wherein, each R is independently H or C CH 3; R 1 and R 2 are independently (a) hydrogen, (b) C1-6alkyl optionally substituted with 1 to 3 substituents selected from F, -OH, -OCH 3 and -CH 3 or (c)C1-6alkoxy optionally substituted with 1 to 3 substituents selected from F, -OH, -OCH 3 and -CH 3; or R 1 and R 2 may be joined together with the nitrogen atom to which they are attached to form azetidine, pyrrolidine, piperidine or isoxazolidine; R 3 is C1-10alkyl optionally substituted with 1 to 3 fluoro; R 4 is hydrogen or C1-10alkyl optionally substituted with phenyl; R 5 is C1-8alkyl optionally substituted with one substituent selected from fluoro, morpholino, C3-6cycloalkyl, pyridinyl optionally substituted with C1-6alkyl, phenyl optionally substituted with 1 to 4 substituents selected from: (a) fluoro, (b) hydroxy, (c) C1-6alkyl optionally substituted with 1 to 3 fluoro, (d) C1-6alkenyl, (e) C1-5alkoxy optionally substituted with fluoro, (f) phenyl, (g) phenyloxy, (h) benzyloxy and (i) C1-10alkylphenyl; phenyl optionally substituted with one substituent selected from -NO 2, -NH 2, fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; and pyridinyl optionally substituted with fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; R 4a and R 5a are independently hydrogen or C1-6 alkyl; and R 6 is hydrogen, C1-6alkyl or C3-6cycloalkyl. each R is independently H or C CH 3; R 1 and R 2 are independently (a) hydrogen, (b) C1-6alkyl optionally substituted with 1 to 3 substituents selected from F, -OH, -OCH 3 and -CH 3 or (c)C1-6alkoxy optionally substituted with 1 to 3 substituents selected from F, -OH, -OCH 3 and -CH 3; or R 1 and R 2 may be joined together with the nitrogen atom to which they are attached to form azetidine, pyrrolidine, piperidine or isoxazolidine; R 3 is C1-10alkyl optionally substituted with 1 to 3 fluoro; R 4 is hydrogen or C1-10alkyl optionally substituted with phenyl; R 5 is C1-8alkyl optionally substituted with one substituent selected from fluoro, morpholino, C3-6cycloalkyl, pyridinyl optionally substituted with C1-6alkyl, phenyl optionally substituted with 1 to 4 substituents selected from: (a) fluoro, (b) hydroxy, (c) C1-6alkyl optionally substituted with 1 to 3 fluoro, (d) C1-6alkenyl, (e) C1-5alkoxy optionally substituted with fluoro, (f) phenyl, (g) phenyloxy, (h) benzyloxy and (i) C1-10alkylphenyl; phenyl optionally substituted with one substituent selected from -NO 2, -NH 2, fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; and pyridinyl optionally substituted with fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; C1-8alkyl optionally substituted with one substituent selected from fluoro, morpholino, C3-6cycloalkyl, pyridinyl optionally substituted with C1-6alkyl, phenyl optionally substituted with 1 to 4 substituents selected from: (a) fluoro, (b) hydroxy, (c) C1-6alkyl optionally substituted with 1 to 3 fluoro, (d) C1-6alkenyl, (e) C1-5alkoxy optionally substituted with fluoro, (f) phenyl, (g) phenyloxy, (h) benzyloxy and (i) C1-10alkylphenyl; fluoro, morpholino, C3-6cycloalkyl, pyridinyl optionally substituted with C1-6alkyl, phenyl optionally substituted with 1 to 4 substituents selected from: (a) fluoro, (b) hydroxy, (c) C1-6alkyl optionally substituted with 1 to 3 fluoro, (d) C1-6alkenyl, (e) C1-5alkoxy optionally substituted with fluoro, (f) phenyl, (g) phenyloxy, (h) benzyloxy and (i) C1-10alkylphenyl; (a) fluoro, (b) hydroxy, (c) C1-6alkyl optionally substituted with 1 to 3 fluoro, (d) C1-6alkenyl, (e) C1-5alkoxy optionally substituted with fluoro, (f) phenyl, (g) phenyloxy, (h) benzyloxy and (i) C1-10alkylphenyl; phenyl optionally substituted with one substituent selected from -NO 2, -NH 2, fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; and pyridinyl optionally substituted with fluoro, C1-6alkyl optionally substituted with fluoro and C1-6alkoxy optionally substituted with fluoro; R 4a and R 5a are independently hydrogen or C1-6 alkyl; and R 6 is hydrogen, C1-6alkyl or C3-6cycloalkyl.