An ambulatory medical device capable of delivering therapy to a patient, the ambulatory medical device comprising: a controller located within a housing; at least one ECG sensor; two or more response mechanisms each having a state and being integrated into the housing; a memory disposed in the housing storing an active operation mode parameter identifying an active operation mode from a plurality of operation modes, the plurality of operation modes including a first operation mode requiring changes in a state of one of the two or more response mechanisms, and a second operation mode requiring changes in states of two of the two or more response mechanisms; the controller operatively coupled with the two or more response mechanisms, the controller including at least one processor coupled with the memory and the at least one ECG sensor; and a therapy manager component configured to be executed by the controller to: identify, based on the active operation mode parameter, the active operation mode from the plurality of operation modes; detect, via the at least one ECG sensor, a physiological parameter having a value indicative of a health disorder of the patient; on identifying the active operation mode as the first operation mode requiring changes in a state of one of the two or more response mechanisms, request the patient change the state of one of the two or more response mechanisms in response to detection of the health disorder; monitor the state of each of the two or more response mechanisms within a predetermined period; and delay administration of therapy to the patient in response to detection of a change in the state of one of the two or more response mechanisms within the predetermined period and the identification of the first operation mode as the active operation mode. a controller located within a housing; at least one ECG sensor; two or more response mechanisms each having a state and being integrated into the housing; a memory disposed in the housing storing an active operation mode parameter identifying an active operation mode from a plurality of operation modes, the plurality of operation modes including a first operation mode requiring changes in a state of one of the two or more response mechanisms, and a second operation mode requiring changes in states of two of the two or more response mechanisms; the controller operatively coupled with the two or more response mechanisms, the controller including at least one processor coupled with the memory and the at least one ECG sensor; and a therapy manager component configured to be executed by the controller to: identify, based on the active operation mode parameter, the active operation mode from the plurality of operation modes; detect, via the at least one ECG sensor, a physiological parameter having a value indicative of a health disorder of the patient; on identifying the active operation mode as the first operation mode requiring changes in a state of one of the two or more response mechanisms, request the patient change the state of one of the two or more response mechanisms in response to detection of the health disorder; monitor the state of each of the two or more response mechanisms within a predetermined period; and delay administration of therapy to the patient in response to detection of a change in the state of one of the two or more response mechanisms within the predetermined period and the identification of the first operation mode as the active operation mode. identify, based on the active operation mode parameter, the active operation mode from the plurality of operation modes; detect, via the at least one ECG sensor, a physiological parameter having a value indicative of a health disorder of the patient; on identifying the active operation mode as the first operation mode requiring changes in a state of one of the two or more response mechanisms, request the patient change the state of one of the two or more response mechanisms in response to detection of the health disorder; monitor the state of each of the two or more response mechanisms within a predetermined period; and delay administration of therapy to the patient in response to detection of a change in the state of one of the two or more response mechanisms within the predetermined period and the identification of the first operation mode as the active operation mode.