A compound of Formula or a salt thereof, wherein: X is CR 4a; Y is CR 4b or N; Z is CR 4d or N; provided that zero or 1 of Y, and Z is N; R 1 is: (i) -C NHR 1a; or (ii) isoxazolyl or triazolyl, each substituted with R 1b; R 1a is hydrogen, -CH 2 CH 2 CHF 2, -CH 2 CH 2 CF 3, -CH 2 CH 2 CH(CH 3) 2, -CH 2 CH 2 CH(CH 3)OH, -CH 2 C(CH 3) 2 CH 2 OH, -CH 2 CH 2 C(CH 3) 2 OH, -CH(CH 3)CH 2 CH 2 OH, -CH 2 CHFC(CH 3) 2 OH, -CH 2 CH 2 OCH 3, -CH 2 CH 2 OCH 2 CH 3, -CH 2 CH 2 C(CH 3) 2 NH 2, -CH 2 CH 2 C NH(CH 3), -CH 2 CH 2 C N(CH 3) 2, -CH 2 CH 2 S 2 CH 3, -CH 2 CH 2 CH 2 NHS 2 CH 3, -CH 2 (hydroxymethylcyclopropyl), -CH 2 (hydroxymethyloxetanyl), -CH 2 (isoxazolyl), -CH 2 (oxazolyl), -CH 2 (dioxidotetrahydrothiophenyl), -CH 2 (dioxidotetrahydrothiopyranyl), -CH 2 (dioxidothiomorpholinyl), -CH 2 (methyldioxoimidazolidinyl), -CH 2 (triazolyl), -CH 2 (fluorophenyl), -CH 2 CH 2 (difluoro,hydroxycyclobutyl), -CH 2 CH 2 (cyclopropyl), -CH 2 CH 2 (dioxidotetrahydrothiopyranyl), -CH 2 CH 2 (dioxidothiomorpholinyl), -CH 2 CH 2 (imidazolyl), -CH 2 CH 2 (morpholinyl), -CH 2 CH 2 (oxadiazolyl), -CH 2 CH 2 (piperidinonyl), -CH 2 CH 2 (pyridinyl), -CH 2 CH 2 (pyrrolidinyl), -CH 2 CH 2 ((cyclopropanecarbonyl)pyrrolidinyl), -CH 2 CH 2 (acetylpyrrolidinyl), -CH 2 CH 2 (tetrazolyl), -CH 2 CH 2 (triazolyl), -CH 2 CH 2 C (pyrrolidinyl), -CH 2 CH 2 CH 2 (imidazolyl), -CH 2 CH 2 CH 2 (pyridinyl), -CH 2 CH 2 CH 2 (aminothiazolyl), -CH 2 C (morpholinyl), -C(CH 3) 2 C (morpholinyl), -CH(CH 2 CH 2 OH)(cyclopropyl), tetrahydropyranyl, or a cyclic group selected from C 3-6 cycloalkyl, azetidinyl, piperidinyl, and pyridinyl, each substituted with a substituent selected from -OH, -C CH 3, -C CH 2 CF 3, -C OCH 2 CH 3, -NH 2, -NHC CH 3, -NHC OCH 3, -S 2 CH 3, -S 2 CH 2 CH 2 CF 3, -C (cyclopropyl), -C (morpholinyl), -CH 2 (pyridinyl), -S 2 (pyridinyl), morpholinyl, and triazolyl; R 1b is -CH 2 CH 2 CH 3, -CH 2 CH(CH 3) 2, -CH 2 CH 2 CH(CH 3) 2, -CH 2 CH 2 CH 2 OH, -CH 2 CH 2 S 2 CH 3, -CH 2 (cyclopropyl), acetylazetidinyl, difluoroethylazetidinyl, piperidinyl, acetylpiperidinyl, or methylpyrrolidinonyl; R 2 is -CH 3, -CH 2 CH 3, -CH(CH 3) 2, -CH 2 CHF 2, -CH 2 CH(CH 3)OH, -CH 2 CH 2 C(CH 3) 2 OH, cyclopropyl, methylcyclopropyl, difluorocyclobutyl, oxetanyl, or difluoroethylpyrazolyl; R 3 is phenyl, pyrazolyl, triazolyl, pyridinyl, pyridinonyl, or pyrimidinyl, each substituted with zero to 2 substituents selected from F, -CH 3, and -CN; R 4a is hydrogen; R 4b is hydrogen; R 4c is hydrogen or -CH 3; and R 4d is hydrogen. X is CR 4a; Y is CR 4b or N; Z is CR 4d or N; provided that zero or 1 of Y, and Z is N; R 1 is: (i) -C NHR 1a; or (ii) isoxazolyl or triazolyl, each substituted with R 1b; (i) -C NHR 1a; or (ii) isoxazolyl or triazolyl, each substituted with R 1b; R 1a is hydrogen, -CH 2 CH 2 CHF 2, -CH 2 CH 2 CF 3, -CH 2 CH 2 CH(CH 3) 2, -CH 2 CH 2 CH(CH 3)OH, -CH 2 C(CH 3) 2 CH 2 OH, -CH 2 CH 2 C(CH 3) 2 OH, -CH(CH 3)CH 2 CH 2 OH, -CH 2 CHFC(CH 3) 2 OH, -CH 2 CH 2 OCH 3, -CH 2 CH 2 OCH 2 CH 3, -CH 2 CH 2 C(CH 3) 2 NH 2, -CH 2 CH 2 C NH(CH 3), -CH 2 CH 2 C N(CH 3) 2, -CH 2 CH 2 S 2 CH 3, -CH 2 CH 2 CH 2 NHS 2 CH 3, -CH 2 (hydroxymethylcyclopropyl), -CH 2 (hydroxymethyloxetanyl), -CH 2 (isoxazolyl), -CH 2 (oxazolyl), -CH 2 (dioxidotetrahydrothiophenyl), -CH 2 (dioxidotetrahydrothiopyranyl), -CH 2 (dioxidothiomorpholinyl), -CH 2 (methyldioxoimidazolidinyl), -CH 2 (triazolyl), -CH 2 (fluorophenyl), -CH 2 CH 2 (difluoro,hydroxycyclobutyl), -CH 2 CH 2 (cyclopropyl), -CH 2 CH 2 (dioxidotetrahydrothiopyranyl), -CH 2 CH 2 (dioxidothiomorpholinyl), -CH 2 CH 2 (imidazolyl), -CH 2 CH 2 (morpholinyl), -CH 2 CH 2 (oxadiazolyl), -CH 2 CH 2 (piperidinonyl), -CH 2 CH 2 (pyridinyl), -CH 2 CH 2 (pyrrolidinyl), -CH 2 CH 2 ((cyclopropanecarbonyl)pyrrolidinyl), -CH 2 CH 2 (acetylpyrrolidinyl), -CH 2 CH 2 (tetrazolyl), -CH 2 CH 2 (triazolyl), -CH 2 CH 2 C (pyrrolidinyl), -CH 2 CH 2 CH 2 (imidazolyl), -CH 2 CH 2 CH 2 (pyridinyl), -CH 2 CH 2 CH 2 (aminothiazolyl), -CH 2 C (morpholinyl), -C(CH 3) 2 C (morpholinyl), -CH(CH 2 CH 2 OH)(cyclopropyl), tetrahydropyranyl, or a cyclic group selected from C 3-6 cycloalkyl, azetidinyl, piperidinyl, and pyridinyl, each substituted with a substituent selected from -OH, -C CH 3, -C CH 2 CF 3, -C OCH 2 CH 3, -NH 2, -NHC CH 3, -NHC OCH 3, -S 2 CH 3, -S 2 CH 2 CH 2 CF 3, -C (cyclopropyl), -C (morpholinyl), -CH 2 (pyridinyl), -S 2 (pyridinyl), morpholinyl, and triazolyl; R 1b is -CH 2 CH 2 CH 3, -CH 2 CH(CH 3) 2, -CH 2 CH 2 CH(CH 3) 2, -CH 2 CH 2 CH 2 OH, -CH 2 CH 2 S 2 CH 3, -CH 2 (cyclopropyl), acetylazetidinyl, difluoroethylazetidinyl, piperidinyl, acetylpiperidinyl, or methylpyrrolidinonyl; R 2 is -CH 3, -CH 2 CH 3, -CH(CH 3) 2, -CH 2 CHF 2, -CH 2 CH(CH 3)OH, -CH 2 CH 2 C(CH 3) 2 OH, cyclopropyl, methylcyclopropyl, difluorocyclobutyl, oxetanyl, or difluoroethylpyrazolyl; R 3 is phenyl, pyrazolyl, triazolyl, pyridinyl, pyridinonyl, or pyrimidinyl, each substituted with zero to 2 substituents selected from F, -CH 3, and -CN; R 4a is hydrogen; R 4b is hydrogen; R 4c is hydrogen or -CH 3; and R 4d is hydrogen.