A corrugated cardboard box, shaped like a parallelepiped and having a quadrangular base, particularly for hospital waste, comprising: - two first flaps (5, 6), protruding monolithically from opposite sides of an upper opening of the box, and provided with first slots (7a, 7b, 8a, 8b); - a first lid adapted to close the upper opening of the box by protruding monolithically from another side of said upper opening, said first lid being provided with two mutually opposite second flaps (11, 12) protruding monolithically from the sides that are perpendicular to said side of the upper opening, each one of said second flaps (11, 12) being provided with a respective second slot (11b, 12b); and - a second lid protruding monolithically from the side of the upper opening that lies opposite the side of said upper opening from which the first lid protrudes, that is adapted to overlap, upon folding thereof, the first lid, characterized in that each of said two first flaps (5, 6) is folded into three portions (5a, 5b, 5c, 6a, 6b, 6c) along creases (5d, 5e, 6d, 6e) that are parallel to said opposite sides of said upper opening, whereby the first portion (5a, 6a) of each one of said two first flaps (5, 6) adjacent to said sides of said upper opening and the second portion (5b, 6b) of each one of said two first flaps (5, 6) each comprises a first slot (7a, 7b, 8a, 8b) and together form two layers of a grip handle, and whereby each one of said second flaps (11, 12) of said first lid forms, after folding of said first lid, a third layer of the grip handle between said first and second portions (5a, 5b, 6a, 6b) of each one of said first flaps (5, 6), whereby the two first slots (7a, 7b) of one of said two first flaps and the second slot of one of said second flaps and, respectively, the two first slots (8a, 8b) of the other one of said two first flaps and the second slot of the other one of said second flaps coincide to form said two grip handles each comprising three layers at least in the region that surrounds said slots (7a, 7b, 11b, 8a, 8b, 12b), at least one of said layers having the corrugations of the cardboard at right angles to the upper side of the slots and at least another one of said layers having the corrugations parallel to said side, said second lid comprising locking means (13a, 13b, 15a, 15b) adapted to overlap, upon folding thereof, the end portions (5c, 6c) of each of said two first flaps (5, 6) that are superimposed on said first lid. - two first flaps (5, 6), protruding monolithically from opposite sides of an upper opening of the box, and provided with first slots (7a, 7b, 8a, 8b); - a first lid adapted to close the upper opening of the box by protruding monolithically from another side of said upper opening, said first lid being provided with two mutually opposite second flaps (11, 12) protruding monolithically from the sides that are perpendicular to said side of the upper opening, each one of said second flaps (11, 12) being provided with a respective second slot (11b, 12b); and - a second lid protruding monolithically from the side of the upper opening that lies opposite the side of said upper opening from which the first lid protrudes, that is adapted to overlap, upon folding thereof, the first lid, characterized in that each of said two first flaps (5, 6) is folded into three portions (5a, 5b, 5c, 6a, 6b, 6c) along creases (5d, 5e, 6d, 6e) that are parallel to said opposite sides of said upper opening, whereby the first portion (5a, 6a) of each one of said two first flaps (5, 6) adjacent to said sides of said upper opening and the second portion (5b, 6b) of each one of said two first flaps (5, 6) each comprises a first slot (7a, 7b, 8a, 8b) and together form two layers of a grip handle, and whereby each one of said second flaps (11, 12) of said first lid forms, after folding of said first lid, a third layer of the grip handle between said first and second portions (5a, 5b, 6a, 6b) of each one of said first flaps (5, 6), whereby the two first slots (7a, 7b) of one of said two first flaps and the second slot of one of said second flaps and, respectively, the two first slots (8a, 8b) of the other one of said two first flaps and the second slot of the other one of said second flaps coincide to form said two grip handles each comprising three layers at least in the region that surrounds said slots (7a, 7b, 11b, 8a, 8b, 12b), at least one of said layers having the corrugations of the cardboard at right angles to the upper side of the slots and at least another one of said layers having the corrugations parallel to said side, said second lid comprising locking means (13a, 13b, 15a, 15b) adapted to overlap, upon folding thereof, the end portions (5c, 6c) of each of said two first flaps (5, 6) that are superimposed on said first lid.