A pneumatic tire having a tire cavity, first and second sidewalls (30, 32) extending respectively from first and second tire bead regions (34, 36) to a tire tread region, an air tube connected to the tire and defining an air passageway, the air tube being composed of a flexible material operative to allow an air tube segment near a tire footprint to flatten and close or substantially close the air passageway, the tire footprint in the rotating tire being operative to flatten the air tube segment by segment to pump air from the flattened air tube segments along the air passageway in a direction counter to the direction of tire rotation, an inlet device positioned within the air passageway operative to pass air into and out of the air passageway, and an outlet device positioned within the air passageway operative in an open position to pass pumped air along the air passageway into the tire cavity, wherein (i) the outlet device is positioned within the air passageway at a location opposite or at least substantially opposite the inlet device, or wherein the outlet device and the inlet device are mounted to the air tube substantially 180 degrees apart; and (ii) the air tube is positioned between at least one of the tire bead regions (34, 36) and a region of the tire radially inward of the tire tread region which comes into contact with a rim flange when the tire is mounted on a rim comprising a respective rim flange, or wherein the air tube is positioned between at least one of the tire bead regions (34, 36) and a region of the tire radially inward of the tire tread region which comes into contact with a rim tire mounting surface flange when the tire is mounted on a rim comprising a respective rim tire mounting surface; and wherein the inlet device comprises a T-configured inlet mechanism positioned within the air passageway of the air tube, the T-configured inlet mechanism having oppositely directed first and second sleeves (70, 72) connected to the air tube and in communication with the air passageway through respective first and second sleeve passageways, and an inlet portal disposed between the first and second sleeves (70, 72) operatively positioned to pass air in and out of the first and second sleeve passageways; and/or wherein the outlet device comprises a T-configured outlet mechanism positioned within the air passageway of the air tube, the T-configured outlet mechanism having oppositely directed first and second sleeves (48, 50) connected to the air tube and in communication with the air passageway through respective first and second sleeve passageways, the T-configured outlet mechanism further having a one-way valve means within or between the first and second sleeve passageways operative in an open condition to pass air from a passageway out of the outlet device into the tire cavity; characterized in that the T-configured outlet mechanism and the T-configured inlet mechanism each have two opposite aligned portions provided with the respective sleeves (70, 72, 48, 50) which are aligned with the main extending axis of the air tube and that a respective perpendicular portion of the T-configured outlet mechanism and of the T-configured inlet mechanism to said opposite aligned portions is disposed perpendicular to said main extending axis of said air tube. (i) the outlet device is positioned within the air passageway at a location opposite or at least substantially opposite the inlet device, or wherein the outlet device and the inlet device are mounted to the air tube substantially 180 degrees apart; and (ii) the air tube is positioned between at least one of the tire bead regions (34, 36) and a region of the tire radially inward of the tire tread region which comes into contact with a rim flange when the tire is mounted on a rim comprising a respective rim flange, or wherein the air tube is positioned between at least one of the tire bead regions (34, 36) and a region of the tire radially inward of the tire tread region which comes into contact with a rim tire mounting surface flange when the tire is mounted on a rim comprising a respective rim tire mounting surface; and wherein