An autonomous driving system comprising a control device configured to control autonomous driving of a vehicle, present a first operation instruction, which is a first request or a first proposal, to a driver of the vehicle during the autonomous driving, the first operation instruction requesting the driver to perform a first response operation, prohibit presenting a second operation instruction, which is a second request or a second proposal, different from the first operation instruction to the driver after the first operation instruction is presented and until the first response operation is completed or until a timing at which the first response operation is predicted to be completed, the second operation instruction requesting the driver to perform a second response operation, plan a first operation instruction timing and a second operation instruction timing, the first operation instruction timing being a timing at which the first operation instruction is to be presented, the second operation instruction timing being a timing at which the second operation instruction is to be presented, predict a first response operation period and a second response operation period based on the first operation instruction timing and the second operation instruction timing, the first response operation period being a period from the first operation instruction timing to a first response operation completion timing at which the first response operation is predicted to be completed, the second response operation period being a period from the second operation instruction timing to a second response operation completion timing at which the second response operation is predicted to be completed, and adjust at least one of the first operation instruction timing and the second operation instruction timing such that the first response operation period and the second response operation period do not overlap, when the first response operation period and the second response operation period are predicted to overlap, wherein adjusting comprises setting the planned first operation instruction timing to an earlier time. control autonomous driving of a vehicle, present a first operation instruction, which is a first request or a first proposal, to a driver of the vehicle during the autonomous driving, the first operation instruction requesting the driver to perform a first response operation, prohibit presenting a second operation instruction, which is a second request or a second proposal, different from the first operation instruction to the driver after the first operation instruction is presented and until the first response operation is completed or until a timing at which the first response operation is predicted to be completed, the second operation instruction requesting the driver to perform a second response operation, plan a first operation instruction timing and a second operation instruction timing, the first operation instruction timing being a timing at which the first operation instruction is to be presented, the second operation instruction timing being a timing at which the second operation instruction is to be presented, predict a first response operation period and a second response operation period based on the first operation instruction timing and the second operation instruction timing, the first response operation period being a period from the first operation instruction timing to a first response operation completion timing at which the first response operation is predicted to be completed, the second response operation period being a period from the second operation instruction timing to a second response operation completion timing at which the second response operation is predicted to be completed, and adjust at least one of the first operation instruction timing and the second operation instruction timing such that the first response operation period and the second response operation period do not overlap, when the first response operation period and the second response operation period are predicted to overlap, wherein adjusting comprises setting the planned first operation instruction timing to an earlier time.