A compound of the formula I: wherein: R 1 is selected from the group consisting of: thiophen-2-yl; phenyl; -C 1-6 alkyl; R 2 is selected from the group consisting of: R 2a, -OCH 2 R 2a and -CH=CHR 2a; R 2a is C 6-10 aryl or C 5-10 heterocyclyl, both of which are unsubstituted or substituted with R 14, or is C 3-10 cycloalkyl; R 3 is selected from the group consisting of: Hydrogen; Halogen which is selected from bromine and iodine; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - -C(R 5,R 6)-OH; -CN; -C 2-4 alkenyl; -OC 1-6 alkyl; Q is selected independently from: a. -C 1-6 alkyl; b. -C 2-4 alkynyl; c. -C 2-4 alkenyl; when R 1 is thiophen-2-yl and R 2 is R 2a, R 4 is selected from: Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; Halogen; otherwise R 4 is hydrogen; R 5 and R 6 are selected independently from Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; R 14 is selected from the group consisting of: Hydroxyl; Halogen; C 1-6 alkyl; -CN; -CO 2 H; -C NH 2; -(CH 2) n C 6-10 aryl; -(CH 2) n C 5-10 heterocycle; -NO 2; - -C(R 5,R 6)-OH; -Q(CH 2) n C 5-10 heteroaryl, which is unsubstituted or substituted with R 15; -(CH 2) n C 3-10 cycloalkyl; -Q(CH 2) n C 6-10 aryl, which is unsubstituted or substituted with R 15; R 15 is selected from the group consisiting of: Hydroxyl; Halogen; C 1-6 alkyl; -CN; and n is 0-3; or a pharmaceutically acceptable salt thereof. R 1 is selected from the group consisting of: thiophen-2-yl; phenyl; -C 1-6 alkyl; thiophen-2-yl; phenyl; -C 1-6 alkyl; R 2 is selected from the group consisting of: R 2a, -OCH 2 R 2a and -CH=CHR 2a; R 2a, -OCH 2 R 2a and -CH=CHR 2a; R 2a is C 6-10 aryl or C 5-10 heterocyclyl, both of which are unsubstituted or substituted with R 14, or is C 3-10 cycloalkyl; R 3 is selected from the group consisting of: Hydrogen; Halogen which is selected from bromine and iodine; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - -C(R 5,R 6)-OH; -CN; -C 2-4 alkenyl; -OC 1-6 alkyl; Hydrogen; Halogen which is selected from bromine and iodine; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - C 6-10 aryl, which is unsubstituted or substituted with R 14; - C 5-10 heteroaryl, which is unsubstituted or substituted with R 14; - -C(R 5,R 6)-OH; -CN; -C 2-4 alkenyl; -OC 1-6 alkyl; Q is selected independently from: a. -C 1-6 alkyl; b. -C 2-4 alkynyl; c. -C 2-4 alkenyl; a. -C 1-6 alkyl; b. -C 2-4 alkynyl; c. -C 2-4 alkenyl; when R 1 is thiophen-2-yl and R 2 is R 2a, R 4 is selected from: Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; Halogen; Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; Halogen; otherwise R 4 is hydrogen; R 5 and R 6 are selected independently from Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; Hydrogen; -(CH 2) n CH 3; -OC 1-6 alkyl; R 14 is selected from the group consisting of: Hydroxyl; Halogen; C 1-6 alkyl; -CN; -CO 2 H; -C NH 2; -(CH 2) n C 6-10 aryl; -(CH 2) n C 5-10 heterocycle; -NO 2; - -C(R 5,R 6)-OH; -Q(CH 2) n C 5-10 heteroaryl, which is unsubstituted or substituted with R 15; -(CH 2) n C 3-10 cycloalkyl; -Q(CH 2) n C 6-10 aryl, which is unsubstituted or substituted with R 15; Hydroxyl; Halogen; C 1-6 alkyl; -CN; -CO 2 H; -C NH 2; -(CH 2) n C 6-10 aryl; -(CH 2) n C 5-10 heterocycle; -NO 2; - -C(R 5,R 6)-OH; -Q(CH 2) n C 5-10 heteroaryl, which is unsubstituted or substituted with R 15; -(CH 2) n C 3-10 cycloalkyl; -Q(CH 2) n C 6-10 aryl, which is unsubstituted or substituted with R 15; R 15 is selected from the group consisiting of: Hydroxyl; Halogen; C 1-6 alkyl; -CN; and Hydroxyl; Halogen; C 1-6 alkyl; -CN; and n is 0-3;