A compound of Formula III or III: or a pharmaceutically acceptable salt thereof; wherein: X 1 is CN, COOR 2, or CONR 2 R 3; R 2 and R 3 are independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 -heteroarylalkyl, each of which is optionally substituted with one or more groups selected from halo, C 1 -C 4 alkyl, C 1 -C 4 heteroalkyl, C 1 -C 6 acyl, C 1 -C 6 heteroacyl, hydroxy, amino, and =O; or R 2 and R 3 groups may be linked to form a 3-8 membered ring, optionally containing one or more N, O or S; and each R 2 and R 3 groups, and each ring formed by linking R 2 and R 3 groups together, is optionally substituted with one or more substituents selected from halo, =O, =N-CN, =N-OR', =NR', OR', N(R') 2, SR', SO 2 R', SO 2 NR' 2, NR'SO 2 R', NR'CONR' 2, NR'COOR', NR'COR', CN, COOR', CON(R') 2, OOOR', COR', and NO 2, wherein each R' is independently H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; X 2 is H; n and m are independently H, halogen, CF 3, CN, OR 7, NR 8 R 9, SR 7, SO 2 NR 8 R 9, C 1 -C 10 alkyl, C 1 -C 10 heteroalkyl, C 2 -C 10 alkenyl, or C 2 -C 10 heteroalkenyl, each of which is optionally substituted with one or more halogens, =O, or an optionally substituted 3-7 membered carbocyclic or heterocyclic ring; each R 7, R 8 and R 9 is independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; and X-L-A is selected from: or a pharmaceutically acceptable salt thereof; wherein: X 1 is CN, COOR 2, or CONR 2 R 3; R 2 and R 3 are independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 -heteroarylalkyl, each of which is optionally substituted with one or more groups selected from halo, C 1 -C 4 alkyl, C 1 -C 4 heteroalkyl, C 1 -C 6 acyl, C 1 -C 6 heteroacyl, hydroxy, amino, and =O; or R 2 and R 3 groups may be linked to form a 3-8 membered ring, optionally containing one or more N, O or S; and each R 2 and R 3 groups, and each ring formed by linking R 2 and R 3 groups together, is optionally substituted with one or more substituents selected from halo, =O, =N-CN, =N-OR', =NR', OR', N(R') 2, SR', SO 2 R', SO 2 NR' 2, NR'SO 2 R', NR'CONR' 2, NR'COOR', NR'COR', CN, COOR', CON(R') 2, OOOR', COR', and NO 2, wherein each R' is independently H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; X 2 is H; n and m are independently H, halogen, CF 3, CN, OR 7, NR 8 R 9, SR 7, SO 2 NR 8 R 9, C 1 -C 10 alkyl, C 1 -C 10 heteroalkyl, C 2 -C 10 alkenyl, or C 2 -C 10 heteroalkenyl, each of which is optionally substituted with one or more halogens, =O, or an optionally substituted 3-7 membered carbocyclic or heterocyclic ring; each R 7, R 8 and R 9 is independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; and X-L-A is selected from: X 1 is CN, COOR 2, or CONR 2 R 3; R 2 and R 3 are independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 -heteroarylalkyl, each of which is optionally substituted with one or more groups selected from halo, C 1 -C 4 alkyl, C 1 -C 4 heteroalkyl, C 1 -C 6 acyl, C 1 -C 6 heteroacyl, hydroxy, amino, and =O; or R 2 and R 3 groups may be linked to form a 3-8 membered ring, optionally containing one or more N, O or S; and each R 2 and R 3 groups, and each ring formed by linking R 2 and R 3 groups together, is optionally substituted with one or more substituents selected from halo, =O, =N-CN, =N-OR', =NR', OR', N(R') 2, SR', SO 2 R', SO 2 NR' 2, NR'SO 2 R', NR'CONR' 2, NR'COOR', NR'COR', CN, COOR', CON(R') 2, OOOR', COR', and NO 2, wherein each R' is independently H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; X 2 is H; n and m are independently H, halogen, CF 3, CN, OR 7, NR 8 R 9, SR 7, SO 2 NR 8 R 9, C 1 -C 10 alkyl, C 1 -C 10 heteroalkyl, C 2 -C 10 alkenyl, or C 2 -C 10 heteroalkenyl, each of which is optionally substituted with one or more halogens, =O, or an optionally substituted 3-7 membered carbocyclic or heterocyclic ring; each R 7, R 8 and R 9 is independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 heteroalkyl, C 1 -C 6 acyl, C 2 -C 6 heteroacyl, C 6 -C 10 aryl, C 5 -C 10 heteroaryl, C 7 -C 12 arylalkyl, or C 6 -C 12 heteroarylalkyl; and X-L-A is selected from: