A measurement system for use in characterizing a tissue, the system comprising: i. a probe adapted for operating in either a scan mode for attaching the probe to a tissue by a predetermined required degree of attachment when the probe is placed at contact with the tissue, or a measure mode in which the probe carries out tissue characterization measurement process, said probe comprising: a) a sensing module comprising one or more sensors and configured and operable to measure one or more parameters indicative of one or more states of the tissue; and b) an attachment module configured and operable to enable selective operation of said probe on either one of the scan mode and the measure modes and configured and operable to provide said predetermined required degree of attachment between the sensing module of the probe and the tissue; and ii. a control unit connected to the probe and configured and operable to selectively operate the probe in either one of the scan and measure modes, such that upon identifying existence of the required degree of attachment between the probe and the tissue the control unit operates the probe to the measure mode to carry out the measurement process, said control unit comprising: a) a computer processing unit; and b) a vacuum system connected to said attachment module of the probe, the vacuum system comprising a pump configured and operable to provide a first vacuum level to achieve said predetermined required degree of attachment during the scan mode and a second vacuum level during the measure mode; the measurement system being characterized in that: the vacuum system further comprises a controller utility connected to the CPU, the controller utility comprises a vacuum sensor configured and operable to measure the vacuum level at a distal end of the probe; the CPU is configured and operable to regulate the vacuum level at the distal end of the probe, in response to the vacuum level sensed by the attachment controller utility; and the vacuum system is configured to automatically switch the probe modes from the scan mode to the measure mode, and vice versa, upon receipt of a signal from the CPU. i. a probe adapted for operating in either a scan mode for attaching the probe to a tissue by a predetermined required degree of attachment when the probe is placed at contact with the tissue, or a measure mode in which the probe carries out tissue characterization measurement process, said probe comprising: a) a sensing module comprising one or more sensors and configured and operable to measure one or more parameters indicative of one or more states of the tissue; and b) an attachment module configured and operable to enable selective operation of said probe on either one of the scan mode and the measure modes and configured and operable to provide said predetermined required degree of attachment between the sensing module of the probe and the tissue; and a) a sensing module comprising one or more sensors and configured and operable to measure one or more parameters indicative of one or more states of the tissue; and b) an attachment module configured and operable to enable selective operation of said probe on either one of the scan mode and the measure modes and configured and operable to provide said predetermined required degree of attachment between the sensing module of the probe and the tissue; and ii. a control unit connected to the probe and configured and operable to selectively operate the probe in either one of the scan and measure modes, such that upon identifying existence of the required degree of attachment between the probe and the tissue the control unit operates the probe to the measure mode to carry out the measurement process, said control unit comprising: a) a computer processing unit; and b) a vacuum system connected to said attachment module of the probe, the vacuum system comprising a pump configured and operable to provide a first vacuum level to achieve said predetermined required degree of attachment during the scan mode and a second vacuum level during the measure mode; the measurement system being characterized in that: the vacuum system further comprises a controller utility connected to the CPU, the controller utility comprises a vacuum sensor configured and operable to measure the vacuum level at a distal end of the probe; the CPU is configured and operable to regulate the vacuum level at the distal end of the probe, in response to the vacuum level sensed by the attachment controller utility; and the vacuum system is configured to automatically switch the probe modes from the scan mode to the measure mode, and vice versa, upon receipt of a signal from the CPU. a) a computer processing unit; and b) a vacuum system connected to said attachment module of the probe, the vacuum system comprising a pump configured and operable to provide a first vacuum level to achieve said predetermined required degree of attachment during the scan mode and a second vacuum level during the measure mode; the vacuum system further comprises a controller utility connected to the CPU, the controller utility comprises a vacuum sensor configured and operable to measure the vacuum level at a distal end of the probe; the CPU is configured and operable to regulate the vacuum level at the distal end of the probe, in response to the vacuum level sensed by the attachment controller utility; and the vacuum system is configured to automatically switch the probe modes from the scan mode to the measure mode, and vice versa, upon receipt of a signal from the CPU.