Compounds of Formula wherein: R 1 is hydrogen, or linearC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents; R 2 is selected from the group consisting of linear or branched, C 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryl unsubstituted or substituted with one or more R 6 substituents, heteroaryl unsubstituted or substituted with one or more R 6 substituents, aryl C 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroarylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroaryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heterocycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, CO R 5; R 5 is selected from the group consisting of linear or branched C 1-9 alkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryl unsubstituted or substituted with one or more R 6 substituents, heteroaryl unsubstituted or substituted with one or more R 6 substituents, arylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroarylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroaryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heterocycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents; R 6 is selected from the group consisting of halogen, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino; or R 1 and R 2 together with the nitrogen atom to which they are attached may form a 4- to 7-membered azacyclic ring containing up to two nitrogen atoms; Y 1 and Y 2 are independently selected from C or N; R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, linear or branched C 1-6 alkyl, C 1-6 alkoxy, hydroxy, trifluoromethyl, amino, monoalkylamino, dialkylamino; or pharmaceutically acceptable salts or solvates thereof. R 1 is hydrogen, or linearC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents; R 2 is selected from the group consisting of linear or branched, C 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryl unsubstituted or substituted with one or more R 6 substituents, heteroaryl unsubstituted or substituted with one or more R 6 substituents, aryl C 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroarylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroaryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heterocycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, CO R 5; R 5 is selected from the group consisting of linear or branched C 1-9 alkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkyl unsubstituted or substituted with one or more R 6 substituents, C 3-6 cycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryl unsubstituted or substituted with one or more R 6 substituents, heteroaryl unsubstituted or substituted with one or more R 6 substituents, arylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, aryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroarylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heteroaryloxyC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents, heterocycloalkylC 1-6 alkyl unsubstituted or substituted with one or more R 6 substituents; R 6 is selected from the group consisting of halogen, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino; or R 1 and R 2 together with the nitrogen atom to which they are attached may form a 4- to 7-membered azacyclic ring containing up to two nitrogen atoms; Y 1 and Y 2 are independently selected from C or N; R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, linear or branched C 1-6 alkyl, C 1-6 alkoxy, hydroxy, trifluoromethyl, amino, monoalkylamino, dialkylamino;