A nicotine vapor generator assembly comprising: a reservoir assembly configured to hold a nicotine pre-vapor formulation in a reservoir; and a nicotine vaporizer assembly configured to vaporize the nicotine pre-vapor formulation, wherein the reservoir assembly further includes a reservoir assembly connector assembly defining a connector conduit, the reservoir assembly connector assembly configured to detachably couple with the nicotine vaporizer assembly to establish fluid communication between the nicotine vaporizer assembly and the reservoir based on a connector element of the nicotine vaporizer assembly engaging with the connector conduit, and an isolation structure configured to move in relation to both the reservoir and the reservoir assembly connector assembly between a first position where the isolation structure exposes the nicotine vaporizer assembly to the reservoir and at least partially obstructs the connector conduit to restrict the connector element from disengaging from the connector conduit, and a second position where the isolation structure isolates the nicotine vaporizer assembly from the reservoir and opens the connector conduit to enable the connector element to disengage from the connector conduit. a reservoir assembly configured to hold a nicotine pre-vapor formulation in a reservoir; and a nicotine vaporizer assembly configured to vaporize the nicotine pre-vapor formulation, wherein the reservoir assembly further includes a reservoir assembly connector assembly defining a connector conduit, the reservoir assembly connector assembly configured to detachably couple with the nicotine vaporizer assembly to establish fluid communication between the nicotine vaporizer assembly and the reservoir based on a connector element of the nicotine vaporizer assembly engaging with the connector conduit, and an isolation structure configured to move in relation to both the reservoir and the reservoir assembly connector assembly between a first position where the isolation structure exposes the nicotine vaporizer assembly to the reservoir and at least partially obstructs the connector conduit to restrict the connector element from disengaging from the connector conduit, and a second position where the isolation structure isolates the nicotine vaporizer assembly from the reservoir and opens the connector conduit to enable the connector element to disengage from the connector conduit. a reservoir assembly connector assembly defining a connector conduit, the reservoir assembly connector assembly configured to detachably couple with the nicotine vaporizer assembly to establish fluid communication between the nicotine vaporizer assembly and the reservoir based on a connector element of the nicotine vaporizer assembly engaging with the connector conduit, and an isolation structure configured to move in relation to both the reservoir and the reservoir assembly connector assembly between a first position where the isolation structure exposes the nicotine vaporizer assembly to the reservoir and at least partially obstructs the connector conduit to restrict the connector element from disengaging from the connector conduit, and a second position where the isolation structure isolates the nicotine vaporizer assembly from the reservoir and opens the connector conduit to enable the connector element to disengage from the connector conduit. a first position where the isolation structure exposes the nicotine vaporizer assembly to the reservoir and at least partially obstructs the connector conduit to restrict the connector element from disengaging from the connector conduit, and a second position where the isolation structure isolates the nicotine vaporizer assembly from the reservoir and opens the connector conduit to enable the connector element to disengage from the connector conduit.