A method of making a compound of Formula 9-5, or a pharmaceutically acceptable salt thereof, the method comprising treating a compound of Formula 11-6, with an acid to give a compound of Formula 9-5; and optionally converting the compound of Formula 9-5 to a pharmaceutically acceptable salt; wherein R 3 is selected from C 2-6 alkyl, C 3-8 cycloalkyl, C 2-5 heterocyclyl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, R 6, and R 7; R 4 is selected from C 3-8 cycloalkyl, C 2-5 heterocyclyl, C 6-14 aryl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -CN, R 6, and R 7; each R 6 is independently selected from -OR 8, -N(R 8)R 9, -NR 8 C R 9, -C R 8, -C OR 8, -C N(R 8)R 9, -C N(R 8)OR 9, -C N(R 8)S 2 R 9, -N(R 8)S 2 R 9, -S n R 8, and -S 2 N(R 8)R 9; each R 7 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 8 and R 9 is independently selected from hydrogen or from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 10 is independently selected from -OR 11, -N(R 11)R 12, -N(R 11)C R 12, -C R 11, -C OR 11, -C N(R 11)R 12, -C N(R 11)OR 12, -C N(R 11)S 2 R 12, -NR 11 S 2 R 12, -S n R 11, and -S 2 N(R 11)R 12; each R 11 and R 12 is independently selected from hydrogen and C 1-6 alkyl; each n is independently selected from 0, 1 and 2; and each m is independently selected from 0, 1, 2, 3, and 4; wherein each of the aforementioned heteroaryl moieties has one to four heteroatoms independently selected from N, O, and S, and each of the aforementioned heterocyclyl moieties is saturated or partially unsaturated and has one or two heteroatoms independently selected from N, O, and S. R 3 is selected from C 2-6 alkyl, C 3-8 cycloalkyl, C 2-5 heterocyclyl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, R 6, and R 7; R 4 is selected from C 3-8 cycloalkyl, C 2-5 heterocyclyl, C 6-14 aryl, and C 1-9 heteroaryl, each optionally substituted with from one to five substituents independently selected from halo, oxo, -CN, R 6, and R 7; each R 6 is independently selected from -OR 8, -N(R 8)R 9, -NR 8 C R 9, -C R 8, -C OR 8, -C N(R 8)R 9, -C N(R 8)OR 9, -C N(R 8)S 2 R 9, -N(R 8)S 2 R 9, -S n R 8, and -S 2 N(R 8)R 9; each R 7 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 8 and R 9 is independently selected from hydrogen or from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl-(CH 2) m -, C 6-14 aryl-(CH 2) m -, C 2-5 heterocyclyl-(CH 2) m -, and C 1-9 heteroaryl-(CH 2) m -, each optionally substituted with from one to five substituents independently selected from halo, oxo, -NO 2, -CN, C 1-6 alkyl, C 1-6 haloalkyl, and R 10; each R 10 is independently selected from -OR 11, -N(R 11)R 12, -N(R 11)C R 12, -C R 11, -C OR 11, -C N(R 11)R 12, -C N(R 11)OR 12, -C N(R 11)S 2 R 12, -NR 11 S 2 R 12, -S n R 11, and -S 2 N(R 11)R 12; each R 11 and R 12 is independently selected from hydrogen and C 1-6 alkyl; each n is independently selected from 0, 1 and 2; and each m is independently selected from 0, 1, 2, 3, and 4; wherein each of the aforementioned heteroaryl moieties has one to four heteroatoms independently selected from N, O, and S, and each of the aforementioned heterocyclyl moieties is saturated or partially unsaturated and has one or two heteroatoms independently selected from N, O, and S.