A compound of formula, or a pharmaceutically acceptable salt thereof: wherein: ring is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; ring is pyrrolyl; ring is aryl or heteroaryl; R a, independently for each occurrence, is selected from the group consisting of halogen, cyano, hydroxy, -NH 2, -NH(Ac), -NH(alkyl), -N(alkyl) 2, -NHC (alkyl), -CH 2 NHC (alkyl), -C NH 2, -C (alkyl), optionally substituted aryl, optionally substituted heteroaryl, cycloalkyl, alkoxy, alkyl, (cycloalkyl)alkyl, hydroxyalkyl, aminoalkyl, and haloalkyl; R b, independently for each occurrence, is selected from the group consisting of halogen, cyano, -NR j R k, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (hydroxy)haloalkyl, hydroxy(cycloalkyl)alkyl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, -alkylene-NR j R k, tosyl, -SO 2 (alkyl), -SO 2 (cycloalkyl), -CO(alkyl), -CO(cycloalkyl), -CONH(alkyl), -CON(alkyl) 2, and -CONH(cycloalkyl); R c, independently for each occurrence, is selected from the group consisting of halogen, -OH, -NR j R k, alkoxy, and alkyl; R 1 is selected from the group consisting of -NH 2, -CH 2 COOH, -CH(NH (alkyl))COOH, -CH(NH (arylalkyl))COOH, -CH(NH (cycloalkyl))COOH, -CH(NH (aryl substituted cycloalkyl))COOH, -CO CH 2 aryl, -CO CH 2 heteroaryl, -CO aryl, and -CO heteroaryl; n is 0, 1, or 2; m is 0, 1, or 2; p is 0, 1, or 2; J is -C -, -NH-, -CH 2 -, -O-, -S-, -S -, -SO 2 -, -N(alkyl)-, or -CH(alkyl)-; K is -C -, -NH-, -O-, -CH 2 -, -S-, -S -, -SO 2 -, -N(alkyl)-, or -CH(alkyl)-; wherein at least one of J and K is -C -, -CH 2 -, or -CH(alkyl)-; L is selected from the group consisting of a bond, -CH 2 -, -CH 2 CH 2 -, -CHR 2 -, -CF 2 -, -CFR 2 -, -C -, -C(=NR L)-, and -C(=CHR L)-; wherein R L is H or alkyl; or wherein R L and an occurrence of R c taken together with the intervening atoms form a substituted or unsubstituted heteroaryl ring; R 2 is alkyl, hydroxyalkyl, or haloalkyl; R j and R k are each independently selected from the group consisting of H, alkyl, aminoalkyl, (heterocycloalkyl)alkyl, and heterocycloalkyl; U is N or CR 3; R 3 is H, halogen, alkyl, alkoxy, or haloalkyl; and V is N or CH. ring is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; ring is pyrrolyl; ring is aryl or heteroaryl; R a, independently for each occurrence, is selected from the group consisting of halogen, cyano, hydroxy, -NH 2, -NH(Ac), -NH(alkyl), -N(alkyl) 2, -NHC (alkyl), -CH 2 NHC (alkyl), -C NH 2, -C (alkyl), optionally substituted aryl, optionally substituted heteroaryl, cycloalkyl, alkoxy, alkyl, (cycloalkyl)alkyl, hydroxyalkyl, aminoalkyl, and haloalkyl; R b, independently for each occurrence, is selected from the group consisting of halogen, cyano, -NR j R k, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (hydroxy)haloalkyl, hydroxy(cycloalkyl)alkyl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, -alkylene-NR j R k, tosyl, -SO 2 (alkyl), -SO 2 (cycloalkyl), -CO(alkyl), -CO(cycloalkyl), -CONH(alkyl), -CON(alkyl) 2, and -CONH(cycloalkyl); -SO 2 (cycloalkyl), -CO(alkyl), -CO(cycloalkyl), -CONH(alkyl), -CON(alkyl) 2, and -CONH(cycloalkyl); R c, independently for each occurrence, is selected from the group consisting of halogen, -OH, -NR j R k, alkoxy, and alkyl; R 1 is selected from the group consisting of -NH 2, -CH 2 COOH, -CH(NH (alkyl))COOH, -CH(NH (arylalkyl))COOH, -CH(NH (cycloalkyl))COOH, -CH(NH (aryl substituted cycloalkyl))COOH, -CO CH 2 aryl, -CO CH 2 heteroaryl, -CO aryl, and -CO heteroaryl; n is 0, 1, or 2; m is 0, 1, or 2; p is 0, 1, or 2; J is -C -, -NH-, -CH 2 -, -O-, -S-, -S -, -SO 2 -, -N(alkyl)-, or -CH(alkyl)-; K is -C -, -NH-, -O-, -CH 2 -, -S-, -S -, -SO 2 -, -N(alkyl)-, or -CH(alkyl)-; wherein at least one of J and K is -C -, -CH 2 -, or -CH(alkyl)-; L is selected from the group consisting of a bond, -CH 2 -, -CH 2 CH 2 -, -CHR 2 -, -CF 2 -, -CFR 2 -, -C -, -C(=NR L)-, and -C(=CHR L)-; wherein R L is H or alkyl; or wherein R L and an occurrence of R c taken together with the intervening atoms form a substituted or unsubstituted heteroaryl ring; wherein R L is H or alkyl; or wherein R L and an occurrence of R c taken together with the intervening atoms form a substituted or unsubstituted heteroaryl ring; R 2 is alkyl, hydroxyalkyl, or haloalkyl; R j and R k are each independently selected from the group consisting of H, alkyl, aminoalkyl, (heterocycloalkyl)alkyl, and heterocycloalkyl; U is N or CR 3; R 3 is H, halogen, alkyl, alkoxy, or haloalkyl; and V is N or CH.