mhurhangee/ep-ind-claims huggingface dataset:
An isolated human antibody or antigen-binding fragment thereof which specifically binds to human delta-like ligand 4 (hDll4) for use in treating cancer or reducing or halting tumor growth in a subject by administration in combination with a chemotherapeutic agent, wherein the human antibody or antigen-binding fragment thereof comprises a heavy chain variable region (HCVR) comprising heavy chain CDR1, CDR2 and CDR3 sequences of SEQ ID NO:22, 24 and 26, respectively, and a light chain variable region (LCVR) comprising light chain CDR1, CDR2 and CDR3 sequences of SEQ ID NO:30, 32 and 34, respectively, the chemotherapeutic agent is a platinum-based chemotherapeutic agent or a pyrimidine analogue, and the cancer or tumor is a solid malignancy.
An automatic elevator calling system, comprising: a first wireless signal module (130-1, 130-2) mounted in an elevator car (110-1, 110-2) and configured to broadcast a first wireless signal, the first wireless signal being a data signal comprising first floor information about where the elevator car (110-1, 110-2) is currently located and current traveling direction information about the elevator car (110-1, 110-2), wherein the traveling direction information comprises: "traveling upwards", "traveling downwards" and "not traveled", wherein the first wireless signal module (130-1, 130-2) is further configured to receive and determine information about the movement of the passenger relative to the elevator car (110-1, 110-2), and the information about the movement is determined based on a change in the signal strength of the first wireless signal received by a personal mobile terminal (200-1, 200-2) carried by the passenger and a change in the first floor information and traveling direction information, wherein the first wireless signal module (130-1, 130-2) is further configured to automatically establish a first wireless connection with the personal mobile terminal (200-1, 200-2) based on the first wireless signal, and receive a target floor registration command sent over from the personal mobile terminal (200-1, 200-2) when establishing the first wireless connection. a first wireless signal module (130-1, 130-2) mounted in an elevator car (110-1, 110-2) and configured to broadcast a first wireless signal, the first wireless signal being a data signal comprising first floor information about where the elevator car (110-1, 110-2) is currently located and current traveling direction information about the elevator car (110-1, 110-2), wherein the traveling direction information comprises: "traveling upwards", "traveling downwards" and "not traveled", wherein the first wireless signal module (130-1, 130-2) is further configured to receive and determine information about the movement of the passenger relative to the elevator car (110-1, 110-2), and the information about the movement is determined based on a change in the signal strength of the first wireless signal received by a personal mobile terminal (200-1, 200-2) carried by the passenger and a change in the first floor information and traveling direction information, wherein the first wireless signal module (130-1, 130-2) is further configured to automatically establish a first wireless connection with the personal mobile terminal (200-1, 200-2) based on the first wireless signal, and receive a target floor registration command sent over from the personal mobile terminal (200-1, 200-2) when establishing the first wireless connection.
An exhaust purge device for a gas internal combustion engine which operates using flammable gas as fuel, the exhaust purge device comprising: an exhaust pipe connected to an exhaust collecting pipe of the gas internal combustion engine so as to form an exhaust channel; a blast pipe connected to an upstream portion of the exhaust pipe at one end; an exhaust purge fan connected to another end of the blast pipe and configured to send ambient air to the exhaust channel; and a control device for performing a control to drive the exhaust purge fan, characterized in that the control device includes: a purge-fan operation determination part configured to determine whether the exhaust purge fan has been operated during a previous shutdown; and a purge-fan operation command part configured to operate the purge fan for a set time which is set in advance upon next startup of the gas internal combustion engine if the purge-fan operation determination part determines that the exhaust purge fan has not been operated during the previous shutdown. an exhaust pipe connected to an exhaust collecting pipe of the gas internal combustion engine so as to form an exhaust channel; a blast pipe connected to an upstream portion of the exhaust pipe at one end; an exhaust purge fan connected to another end of the blast pipe and configured to send ambient air to the exhaust channel; and a control device for performing a control to drive the exhaust purge fan, characterized in that the control device includes: a purge-fan operation determination part configured to determine whether the exhaust purge fan has been operated during a previous shutdown; and a purge-fan operation command part configured to operate the purge fan for a set time which is set in advance upon next startup of the gas internal combustion engine if the purge-fan operation determination part determines that the exhaust purge fan has not been operated during the previous shutdown.
A gearbox for a road vehicle comprising: - a gearbox case, - a rigid first shaft, a rigid second shaft, and a rigid third shaft, - a first set of first gear assemblies located inside the gearbox case, wherein each first gear assembly comprises: a first gear wheel centered on the first shaft, a second gear wheel centered on the second shaft, and a single wet clutch configured to engage and disengage the first gear assembly, - a second set of second gear assemblies located inside the gearbox case, wherein each second gear assembly comprises: a third gear wheel centered on the second shaft, a fourth gear wheel centered on the third shaft, and a single wet clutch configured to engage and disengage the second gear assembly, wherein in each of the first gear assemblies, the wet-clutch is positioned either before or after the first gear wheel and the second gear wheel, and in each of the second gear assemblies, the wet-clutch is positioned either before or after the third gear wheel and the fourth gear wheel, characterized in that a second gear assembly of the second set provides a gear ratio between the third shaft and the second shaft that is greater than the gear ratios between the second shaft and the first shaft provided by each of the first gear assemblies of the first set. - a gearbox case, - a rigid first shaft, a rigid second shaft, and a rigid third shaft, - a first set of first gear assemblies located inside the gearbox case, wherein each first gear assembly comprises: a first gear wheel centered on the first shaft, a second gear wheel centered on the second shaft, and a single wet clutch configured to engage and disengage the first gear assembly, a first gear wheel centered on the first shaft, a second gear wheel centered on the second shaft, and a single wet clutch configured to engage and disengage the first gear assembly, - a second set of second gear assemblies located inside the gearbox case, wherein each second gear assembly comprises: a third gear wheel centered on the second shaft, a fourth gear wheel centered on the third shaft, and a single wet clutch configured to engage and disengage the second gear assembly, wherein a third gear wheel centered on the second shaft, a fourth gear wheel centered on the third shaft, and a single wet clutch configured to engage and disengage the second gear assembly, wherein
A developer supply container, comprising a rotating container for conveying a developer, and an intermittent regulator for intermittently supplying a gas into the rotating container and regulating an internal pressure of the rotating container; wherein an end portion of one end of the rotating container is provided with a powder discharging bin; a part of an inner space of the powder discharging bin forms a gas mixing space for accommodating the developer; a bottom of the powder discharging bin is provided with a powder discharging port for discharging the developer; the powder discharging port is located below the gas mixing space; and the intermittent regulator is configured to intermittently supply a fixed amount of gas to the gas mixing space, and after the fixed amount of gas is mixed with the developer, the developer in the gas mixing space discharges from the powder discharging port with the fixed amount of gas, wherein the rotating container comprises a connecting cylinder and a receiving drum; one end of the connecting cylinder is rotatably connected to one end of the powder discharging bin; and the other end of the connecting cylinder is connected to the receiving drum by a threaded connection, characterized in that the intermittent regulator comprises a cam piston having a cam surface; the one end of the connecting cylinder is provided with a first stirring plate, an end surface of one end of the first stirring plate is in contact with the cam surface of the cam piston; and when the first stirring plate rotates, the first stirring plate drives the cam piston to perform a reciprocating translational motion along an inner wall of the powder discharging bin.
A composition comprising a bacterial collagen-binding polypeptide segment linked to a therapeutic agent for use in treating a collagenopathy in a subject in need of treatment with the therapeutic agent, wherein the therapeutic agent is not a PTH/PTHrP receptor antagonist, wherein the bacterial collagen-binding polypeptide segment delivers the agent to sites comprising partially untwisted or under-twisted collagen, and wherein the collagenopathy is characterized by sites of partially untwisted or under-twisted collagen.
A power unit, comprising: a shift drum; a rotation plate fixed to an end of the shift drum, to thereby rotate with the shift drum, the rotation plate including an outer peripheral surface having a plurality of recessed portions; a shift lever configured to engage with the rotation plate; a shift shaft fixed to the shift lever, and being rotatable between a first rotational position and a second rotational position; a support shaft disposed substantially in parallel with the shift drum; a stopper lever rotatably supported by the support shaft; a stopper roller provided in the stopper lever, the stopper roller being configured to engage with one of the recessed portions of the rotation plate when the shift shaft is in the first rotational position; an elastic member configured to engage with the stopper lever, so as to apply a force to the stopper lever to thereby press the stopper roller against the one recessed portion; a crankcase housing the shift drum, the rotation plate, the shift lever, the support shaft, the stopper lever, the stopper roller, the elastic member, and at least a portion of the shift shaft; and an oil pan disposed under the crankcase, wherein the crankcase includes a frame portion that is located higher than the oil pan and to which a cover is attached when viewed in an axial direction of the shift shaft, and characterized in that: the shift lever and the stopper lever are so disposed that when the shift shaft is located at the second rotational position, at least one of a portion of the shift lever and a portion of the stopper lever is located lower than the frame portion of the crankcase and inside the oil pan as viewed in the axial direction of the shift shaft. a shift drum; a rotation plate fixed to an end of the shift drum, to thereby rotate with the shift drum, the rotation plate including an outer peripheral surface having a plurality of recessed portions; a shift lever configured to engage with the rotation plate; a shift shaft fixed to the shift lever, and being rotatable between a first rotational position and a second rotational position; a support shaft disposed substantially in parallel with the shift drum; a stopper lever rotatably supported by the support shaft; a stopper roller provided in the stopper lever, the stopper roller being configured to engage with one of the recessed portions of the rotation plate when the shift shaft is in the first rotational position; an elastic member configured to engage with the stopper lever, so as to apply a force to the stopper lever to thereby press the stopper roller against the one recessed portion; a crankcase housing the shift drum, the rotation plate, the shift lever, the support shaft, the stopper lever, the stopper roller, the elastic member, and at least a portion of the shift shaft; and an oil pan disposed under the crankcase, the shift lever and the stopper lever are so disposed that when the shift shaft is located at the second rotational position, at least one of a portion of the shift lever and a portion of the stopper lever is located lower than the frame portion of the crankcase and inside the oil pan as viewed in the axial direction of the shift shaft.
Method for control and regulation of an internal combustion engine with exhaust gas recirculation, in which an EGR rate (AGRR) is determined by means of a Kalman filter from calculated and measured variables of the gas path and from calculated and measured variables of the combustion, characterised in that nitrogen oxide values (NOx) are taken into account as emission values of the combustion when calculating the EGR rate (AGRR).
A vehicle remote control method comprising: detecting (S21, S101) a relative position of an extension unit with respect to a vehicle by using a base unit and the extension unit, the extension unit being located outside the vehicle and constituting a keyless entry system with the base unit equipped in the vehicle; characterized by setting, in accordance with the relative position of the extension unit, a command touch operation for operating the vehicle with a remote operation device; detecting a touch operation that an operator inputs to a touch panel of the remote operation device; determining whether or not the touch operation detected is the command touch operation, and when the touch operation is the command touch operation (S106; Yes), controlling (S12, S22, S108) the vehicle to execute autonomous travel control, the vehicle having an autonomous travel control function. detecting (S21, S101) a relative position of an extension unit with respect to a vehicle by using a base unit and the extension unit, the extension unit being located outside the vehicle and constituting a keyless entry system with the base unit equipped in the vehicle; characterized by setting, in accordance with the relative position of the extension unit, a command touch operation for operating the vehicle with a remote operation device; detecting a touch operation that an operator inputs to a touch panel of the remote operation device; determining whether or not the touch operation detected is the command touch operation, and when the touch operation is the command touch operation (S106; Yes), controlling (S12, S22, S108) the vehicle to execute autonomous travel control, the vehicle having an autonomous travel control function.
Die head for the production of multilayer tubular film made of thermoplastic polymers comprising one or more melt feeders, one or more melt channels (8, 9, 10, 11, 12) arranged concentrically around the centre axis of the die head with distributors, whereby the melt channels (8, 9, 10, 11, 12) are delimited by annular elements (2, 3, 4, 5, 6, 7) and a ring-shaped die into which the melt channels (8, 9, 10, 11, 12) discharge, characterised in that at least one distributor is an axial spiral distributor and at least one distributor is a plate distributor with spiral distributor, whereby the plate distributor is located in an annular element (2, 3, 4, 5, 6, 7) of the axial spiral distributor upstream of where the melt merges into the ring-shaped die.
A differential amplifier comprising: a first amplifier leg comprising a first transistor (T 1); and a second amplifier leg comprising a second transistor (T 2); wherein the first transistor (T 1) is configured to have a bulk potential different from a bulk potential of the second transistor (T 2); characterized in that the differential amplifier is configured to be an input stage of comparator; wherein the first amplifier leg and the second amplifier leg, together, are configured to differentially amplify a received differential input signal; wherein the differential amplifier is configured to have an input offset voltage; wherein the input offset voltage corresponds to the difference between the bulk potential of the first transistor and the bulk potential of the second transistor; wherein the bulk potential of at least one of the first and second transistors is controlled, such that a range of threshold levels of the comparator is extendable; wherein the first transistor (T 1) has a first device size and the second transistor (T 2) has a second device size different from the first device size, and wherein the input offset voltage further corresponds to the difference between the first device size and the second device size. a first amplifier leg comprising a first transistor (T 1); and a second amplifier leg comprising a second transistor (T 2); wherein the first transistor (T 1) is configured to have a bulk potential different from a bulk potential of the second transistor (T 2); characterized in that the differential amplifier is configured to be an input stage of comparator; wherein the first amplifier leg and the second amplifier leg, together, are configured to differentially amplify a received differential input signal; wherein the differential amplifier is configured to have an input offset voltage; wherein the input offset voltage corresponds to the difference between the bulk potential of the first transistor and the bulk potential of the second transistor; wherein the bulk potential of at least one of the first and second transistors is controlled, such that a range of threshold levels of the comparator is extendable; wherein the first transistor (T 1) has a first device size and the second transistor (T 2) has a second device size different from the first device size, and wherein the input offset voltage further corresponds to the difference between the first device size and the second device size.
A 1,4,5-trisubstituted 1,2,3-triazole compound of formula: wherein: R 1 is a biradical selected from the group consisting of C 1-20 alkylene; in which 0, 1, 2, 3, 4, 5 or 6 -CH 2 - groups are optionally replaced by groups selected from -O-, -S-, -C O-, -C NH-, -C N(C 1-4 alkyl)-, -NHC NH-,-NHC O-; and R 2 is a biradical independently selected from the group consisting of: C 1-6 alkylene; in which 0, 1, 2 or 3 -CH 2 - groups are optionally replaced by groups selected from -O- and -S-; optionally substituted with one or more groups selected from C 1-4 alkyl, phenyl, C 6-10 aryl; and R 3 is a biradical selected from the group consisting of: C 1-6 alkylene; optionally containing one or more -C=C- bonds; optionally containing -C=C- bonds; in which 0, 1, 2 or 3 -CH 2 - groups are optionally replaced by groups selected from -O- and -S-; optionally substituted with one or more groups selected from C 1-4 alkyl, phenyl, -F, -Cl, -OH, -O(C 1-4 alkyl), -S(C 1-4 alkyl), -SO 2 Ph,-CN, -NO 2, -CO(C 1-4 alkyl), -CO 2 H, -CO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2; and X is a group selected from the group consisting of: azido, N-maleimido, N-maleimido-furan cycloadduct, thiol, thio acid, azido, sulfonylazido, ethynyl, iodoethynyl and an activated cyclooctynyl group represented by the formulae: Y is a group selected from -NHC(=NH)NH 2 and C 6 H 4 -OH Z is a group selected from -CO 2 H and Ph, and when Y is -NHC(=NH)NH 2, Z is -CO 2 H, and when Y is C 6 H 4 -OH, Z is Ph. R 1 is a biradical selected from the group consisting of C 1-20 alkylene; in which 0, 1, 2, 3, 4, 5 or 6 -CH 2 - groups are optionally replaced by groups selected from -O-, -S-, -C O-, -C NH-, -C N(C 1-4 alkyl)-, -NHC NH-,-NHC O-; and R 2 is a biradical independently selected from the group consisting of: C 1-6 alkylene; in which 0, 1, 2 or 3 -CH 2 - groups are optionally replaced by groups selected from -O- and -S-; optionally substituted with one or more groups selected from C 1-4 alkyl, phenyl, C 6-10 aryl; and R 3 is a biradical selected from the group consisting of: C 1-6 alkylene; optionally containing one or more -C=C- bonds; optionally containing -C=C- bonds; in which 0, 1, 2 or 3 -CH 2 - groups are optionally replaced by groups selected from -O- and -S-; optionally substituted with one or more groups selected from C 1-4 alkyl, phenyl, -F, -Cl, -OH, -O(C 1-4 alkyl), -S(C 1-4 alkyl), -SO 2 Ph,-CN, -NO 2, -CO(C 1-4 alkyl), -CO 2 H, -CO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2; and X is a group selected from the group consisting of: azido, N-maleimido, N-maleimido-furan cycloadduct, thiol, thio acid, azido, sulfonylazido, ethynyl, iodoethynyl and an activated cyclooctynyl group represented by the formulae: Y is a group selected from -NHC(=NH)NH 2 and C 6 H 4 -OH Z is a group selected from -CO 2 H and Ph, and when Y is -NHC(=NH)NH 2, Z is -CO 2 H, and when Y is C 6 H 4 -OH, Z is Ph.
An n-channel or ambipolar field-effect transistor including an organic semiconductive layer having an electron affinity EA semicond; and an organic gate dielectric layer forming an interface with the semiconductive layer; characterised in that the bulk concentration of trapping groups in the gate dielectric layer is less than 10 18 cm -3, where a trapping group is a group having (i) an electron affinity EA x greater than or equal to EA semicond and/or (ii) a reactive electron affinity EA rxn greater than or equal to (EA semicond. -2eV).
An apparatus for securing an access protection scheme, comprising: a memory (38, 40); and a controller configured to receive a command along a command path and authenticate the command by executing an authentication technique, wherein the controller is associated with a register (42, 44), wherein the register (42, 44) is configured to store an indication of whether an access protection scheme of the memory (38, 40) is alterable, wherein the controller is configured to prevent alteration to the indication stored in the register (42, 44) until the command is authenticated as being properly issued from an authorized sender via execution of the authentication technique. a memory (38, 40); and a controller configured to receive a command along a command path and authenticate the command by executing an authentication technique, wherein the controller is associated with a register (42, 44), wherein the register (42, 44) is configured to store an indication of whether an access protection scheme of the memory (38, 40) is alterable, wherein the controller is configured to prevent alteration to the indication stored in the register (42, 44) until the command is authenticated as being properly issued from an authorized sender via execution of the authentication technique.