A system for providing access to a vessel, the system comprising: an adjustable delivery handle system comprising: a delivery handle assembly, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable subassemblies; an inner hub housing coupled to the delivery handle assembly, the inner hub housing having a first plurality of radially-spaced barbs disposed on an inner diameter thereof; and a sheath coupled to a distal end of the handle assembly and having a lumen in fluid communication with the inner lumen of the delivery handle assembly; and an access catheter subassembly removably disposed within the inner lumen of the delivery handle assembly and lumen of the sheath, the access catheter subassembly comprising: an access catheter having an elongate tubular body having a proximal section having a proximal end, a distal section having a distal end, an outer surface, an inner surface defining a lumen extending from the proximal end to the distal end, and a catheter hub configured for insertion into the inner hub housing, the catheter hub having a second plurality of radially-spaced barbs disposed on an outer diameter thereof, wherein the distal section includes an adjustable portion along a length thereof configured to transition to at least a pre-defined arcuate shape wherein each of the second plurality of barbs is configured for selective engagement with a corresponding one of the first plurality of barbs to permit incremental rotation of the catheter hub relative to the inner hub housing; and wherein the proximal section of the access catheter is coupled to the catheter hub, wherein the distal section of the access catheter is configured to incrementally rotate about a longitudinal axis defined by the lumen of the catheter body in conjunction with incremental rotation of the catheter hub. an adjustable delivery handle system comprising: a delivery handle assembly, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable subassemblies; an inner hub housing coupled to the delivery handle assembly, the inner hub housing having a first plurality of radially-spaced barbs disposed on an inner diameter thereof; and a sheath coupled to a distal end of the handle assembly and having a lumen in fluid communication with the inner lumen of the delivery handle assembly; and a delivery handle assembly, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable subassemblies; an inner hub housing coupled to the delivery handle assembly, the inner hub housing having a first plurality of radially-spaced barbs disposed on an inner diameter thereof; and a sheath coupled to a distal end of the handle assembly and having a lumen in fluid communication with the inner lumen of the delivery handle assembly; and an access catheter subassembly removably disposed within the inner lumen of the delivery handle assembly and lumen of the sheath, the access catheter subassembly comprising: an access catheter having an elongate tubular body having a proximal section having a proximal end, a distal section having a distal end, an outer surface, an inner surface defining a lumen extending from the proximal end to the distal end, and a catheter hub configured for insertion into the inner hub housing, the catheter hub having a second plurality of radially-spaced barbs disposed on an outer diameter thereof, wherein the distal section includes an adjustable portion along a length thereof configured to transition to at least a pre-defined arcuate shape wherein each of the second plurality of barbs is configured for selective engagement with a corresponding one of the first plurality of barbs to permit incremental rotation of the catheter hub relative to the inner hub housing; and wherein the proximal section of the access catheter is coupled to the catheter hub, wherein the distal section of the access catheter is configured to incrementally rotate about a longitudinal axis defined by the lumen of the catheter body in conjunction with incremental rotation of the catheter hub. an access catheter having an elongate tubular body having a proximal section having a proximal end, a distal section having a distal end, an outer surface, an inner surface defining a lumen extending from the proximal end to the distal end, and a catheter hub configured for insertion into the inner hub housing, the catheter hub having a second plurality of radially-spaced barbs disposed on an outer diameter thereof, wherein the distal section includes an adjustable portion along a length thereof configured to transition to at least a pre-defined arcuate shape wherein each of the second plurality of barbs is configured for selective engagement with a corresponding one of the first plurality of barbs to permit incremental rotation of the catheter hub relative to the inner hub housing; and wherein the proximal section of the access catheter is coupled to the catheter hub, wherein the distal section of the access catheter is configured to incrementally rotate about a longitudinal axis defined by the lumen of the catheter body in conjunction with incremental rotation of the catheter hub.