mhurhangee/ep-ind-claims huggingface dataset:
A heterocyclic compound having the general formula: or a pharmaceutically acceptable salt or hydrate thereof; wherein in the general formula, the structural unit having the general formula: is a structural unit selected from structural units having the general formula: in the general formula. R 1 and R 2 each are a functional group independently selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, amino group, acetylamino group, benzylamino group, trifluoromethyl group, C 1 -C 6 alkyl group, C 1 -C 6 alkoxy group, and - O-(CH 2)n-R 5 (R 5 is a vinyl group, C 3 -C 6 cycloalkyl group, or phenyl group, and n is 0 or 1); R 3 and R 4 together form a spiro ring having the general formula: in the general formula, the structural unit B is a structural unit selected from structural units having the general formula: said structural unit B binds at a position marked by * in the general formula to form a spiro ring; and R 8 is a functional group selected from the group consisting of a hydrogen atom, halogen atom, hydroxy group, C 1 -C 6 alkoxy group, cyano group, and trifluoromethyl group, for use in improving and/or delaying the worsening of symptoms of one or more conditions associated with senescence, selected from the group consisting of reactivity, passivity, glossiness and/or coarseness of hair, hair loss, ulcers, periophthalmic lesions, cataracts, corneal opacity and/or lordokyphosis.
A solid dosage form for sublingual or buccal administration of a hormone having low to poor aqueous solubility, said dosage form comprising melatonin in a dissolved state, said dissolved melatonin being associated with a pharmaceutically acceptable carrier wherein the melatonin is in a dissolved state in the final dosage form, wherein the dissolved melatonin is adsorbed onto said carrier, wherein the melatonin is dissolved in a pharmaceutically acceptable solvent selected from polyethylene glycol, ethanol, isopropyl alcohol, substituted polyethylene glycols, propylene glycol or a mixture thereof, and wherein the pharmaceutically acceptable carrier is silica, wherein the solid dosage form is in the form of a tablet.
A chemical mechanical polishing composition comprising: a water based liquid carrier; colloidal silica abrasive particles dispersed in the liquid carrier; a chemical species incorporated in the colloidal silica abrasive particles internal to an outer surface thereof, wherein the chemical species is a nitrogen containing compound or a phosphorus containing compound; a pH in a range from 1.5 to 7; wherein the colloidal silica abrasive particles have a permanent positive charge of at least 13 mV; and wherein an aminosilane compound is bonded with the outer surface of the colloidal silica abrasive particles. a water based liquid carrier; colloidal silica abrasive particles dispersed in the liquid carrier; a chemical species incorporated in the colloidal silica abrasive particles internal to an outer surface thereof, wherein the chemical species is a nitrogen containing compound or a phosphorus containing compound; a pH in a range from 1.5 to 7; wherein the colloidal silica abrasive particles have a permanent positive charge of at least 13 mV; and wherein an aminosilane compound is bonded with the outer surface of the colloidal silica abrasive particles.
Process for the production of dialkyl carbonate and alkanediol from the transesterification of alkylene carbonate and alkanol, in which process (a) the alkylene carbonate and an alkanol feedstock are introduced into a reaction zone to react in the presence of a transesterification catalyst to yield an alkanediol-rich stream and a stream comprising dialkyl carbonate and alkanol which streams are separated; (b) the stream comprising dialkyl carbonate and alkanol is passed to an extractive distillation zone in which an extractant is added to the stream; (c) from the extractive distillation zone an alkanol-rich vapour stream is obtained and a bottom stream containing the extractant and the dialkyl carbonate; (d) the bottom stream from step (c) is separated in a second non-extractive distillation zone to yield a dialkyl carbonate-rich top stream and a extractant-rich bottom stream; (e) the extractant-rich bottom stream is at least partly recycled to the extractive distillation zone, wherein the extractant-rich bottom stream is used as heat source for the alkanol feedstock. (a) the alkylene carbonate and an alkanol feedstock are introduced into a reaction zone to react in the presence of a transesterification catalyst to yield an alkanediol-rich stream and a stream comprising dialkyl carbonate and alkanol which streams are separated; (b) the stream comprising dialkyl carbonate and alkanol is passed to an extractive distillation zone in which an extractant is added to the stream; (c) from the extractive distillation zone an alkanol-rich vapour stream is obtained and a bottom stream containing the extractant and the dialkyl carbonate; (d) the bottom stream from step (c) is separated in a second non-extractive distillation zone to yield a dialkyl carbonate-rich top stream and a extractant-rich bottom stream; (e) the extractant-rich bottom stream is at least partly recycled to the extractive distillation zone,
A method for predicting a wind power density using a stepwise regression analysis technique, configured in a form of a program executed by an execution processing means including a computer, comprising: a variable inputting step of inputting the wind power density, which is an output variable, and two or more input variables selected among ground roughnesses (r1 to r6), an elevation, a relative elevation difference, a terrain openness, a wide region terrain openness, aspects (a1 to a7), a slope, a relative slope, a mean elevation, a maximum elevation, a minimum elevation, a relative relief, a distance from a coast, and reinterpretation meteorology data; a stepwise regression analyzing step of receiving the output variable and the input variables input in the variable inputting step and performing a regression analysis method by a stepwise variable selection method; and a multiple regression equation estimating step of estimating a multiple regression equation having the highest Coefficient of determination(R 2) value using regression coefficients calculated in the stepwise regression analyzing step, wherein the stepwise regression analyzing step further comprises a variable transforming step of transforming the input variables using nominal variables among the output variable and the input variables input in the variable inputting step into dummy variables, while using each of the output variable and the input variables in an original variable form or performing a variable transformation of each of the output variable and the input variables, the variable transformation being a log transformation or a square root transformation. a variable inputting step of inputting the wind power density, which is an output variable, and two or more input variables selected among ground roughnesses (r1 to r6), an elevation, a relative elevation difference, a terrain openness, a wide region terrain openness, aspects (a1 to a7), a slope, a relative slope, a mean elevation, a maximum elevation, a minimum elevation, a relative relief, a distance from a coast, and reinterpretation meteorology data; a stepwise regression analyzing step of receiving the output variable and the input variables input in the variable inputting step and performing a regression analysis method by a stepwise variable selection method; and a multiple regression equation estimating step of estimating a multiple regression equation having the highest Coefficient of determination(R 2) value using regression coefficients calculated in the stepwise regression analyzing step, wherein the stepwise regression analyzing step further comprises a variable transforming step of transforming the input variables using nominal variables among the output variable and the input variables input in the variable inputting step into dummy variables, while using each of the output variable and the input variables in an original variable form or performing a variable transformation of each of the output variable and the input variables, the variable transformation being a log transformation or a square root transformation.
Control procedure of an apparatus for the rapid cooling of packaged beverages, the control procedure comprising the following sequential steps: I) driving through the commanding of a control unit connected to a first driving means the rotation of a vertical axial rotation axis connected to a gripping means for at least one container, said rotation within a speed range from 500 RPM to 2500 RPM for a period of time ranging from 0.1 seconds to 7 seconds, said container submerged into a thermally insulated immersion tank, said immersion tank containing a liquid refrigerant, and an evaporation coil of fluid refrigerant from a closed refrigeration circuit, II) slowing down, without stopping it completely, through the commanding of the control unit the rotation of said vertical axial rotation axis to a speed not exceeding 500 RPM, and simultaneously, through the commanding of the control unit connected to a second driving means for driving a vertically movable cart driving a vertical reciprocating movement of said vertically moving cart, for a period of time ranging from 0.1 seconds to 3 seconds. III) establishing through the control unit the number of repetitions of steps I) and II) up to the final stop of the rotation of said vertical axial rotation axis. I) driving through the commanding of a control unit connected to a first driving means the rotation of a vertical axial rotation axis connected to a gripping means for at least one container, said rotation within a speed range from 500 RPM to 2500 RPM for a period of time ranging from 0.1 seconds to 7 seconds, said container submerged into a thermally insulated immersion tank, said immersion tank containing a liquid refrigerant, and an evaporation coil of fluid refrigerant from a closed refrigeration circuit, II) slowing down, without stopping it completely, through the commanding of the control unit the rotation of said vertical axial rotation axis to a speed not exceeding 500 RPM, and simultaneously, through the commanding of the control unit connected to a second driving means for driving a vertically movable cart driving a vertical reciprocating movement of said vertically moving cart, for a period of time ranging from 0.1 seconds to 3 seconds. III) establishing through the control unit the number of repetitions of steps I) and II) up to the final stop of the rotation of said vertical axial rotation axis.
A method for determining positions of molecules spaced apart from one another in one or more spatial directions in a sample comprising the steps of: - generating a plurality of light distributions, each light distribution comprising a local intensity minimum (110, 310) and intensity increasing regions (120, 320) adjacent thereto, the light distributions comprising an excitation light distribution and a deactivation light distribution, particularly a STED light distribution, - illuminating the sample with the excitation light distribution and the deactivation light distribution, - detecting photons emitted by the molecule for different positionings of the excitation light distribution, and - deriving the position of the molecule based on the photons detected for the different positionings of the excitation light distribution, wherein the local minimum of the excitation light distribution is successively arranged at a plurality of scanning positions within a scanning region, characterized in that the light intensity of the deactivation light in a catch region assigned to the scanning region, in which the position of the molecule can be unambiguously derived from the scanning positions and the associated detected photons, corresponds at most to a saturation intensity. - generating a plurality of light distributions, each light distribution comprising a local intensity minimum (110, 310) and intensity increasing regions (120, 320) adjacent thereto, the light distributions comprising an excitation light distribution and a deactivation light distribution, particularly a STED light distribution, - illuminating the sample with the excitation light distribution and the deactivation light distribution, - detecting photons emitted by the molecule for different positionings of the excitation light distribution, and - deriving the position of the molecule based on the photons detected for the different positionings of the excitation light distribution, wherein the local minimum of the excitation light distribution is successively arranged at a plurality of scanning positions within a scanning region, characterized in that the light intensity of the deactivation light in a catch region assigned to the scanning region, in which the position of the molecule can be unambiguously derived from the scanning positions and the associated detected photons, corresponds at most to a saturation intensity. wherein the local minimum of the excitation light distribution is successively arranged at a plurality of scanning positions within a scanning region, characterized in that the light intensity of the deactivation light in a catch region assigned to the scanning region, in which the position of the molecule can be unambiguously derived from the scanning positions and the associated detected photons, corresponds at most to a saturation intensity.
An integrated power umbilical, including at least one power cable to transfer large amounts of electric energy/power, filler material (2, 3) in the form of stiff, elongated plastic elements, laying at least partly around and between the power cables, which are collectively collected into a twisted bundle by means of a laying and closing operation, and a protective sheath that encapsulates the power cables and the filler material (2, 3), and at least one additional metallic high ohm electric conductor is arranged in the transverse cross section of the high power umbilical and extends in the longitudinal direction of the power umbilical, which at least one electric conductor is located separate from and external of the high power cables, said at least one electric conductor being able to drain off, or dissipate, capacitive currents arising in the high power umbilical when conducting large amounts of electric energy/power, characterized in that the surrounding elements, i.e. the filler material (2, 3) and the sheath, is made of a semiconducting material, said semiconducting material being able to drain off, or dissipate, capacitive currents arising in the power umbilical when the power cable conducts large amounts of electric energy/power, and that the stiff, elongate plastic elements (2, 3) include longitudinally extending channels (C 2) for receipt of seawater, and the protective outer sheath comprises substantially radially extending channels (C 1) that communicate with the longitudinally extending channels (C 2), said seawater forming communication to transport away or dissipate capacitive currents generated in the power umbilical.
Door-lock system for a household appliance, such as a washing machine and the like, of the type provided with a door, to which a hook is associated, and a member to be moved of said household appliance, such as a washing drum or the like, said door-lock system comprising motor means for operating said member to be moved and a door-lock device, capable of interacting with said hook, to lock said door, characterized in that said door-lock system comprises a control unit, capable of controlling the power supply of said motor means and connected to said door-lock device, so as to control the power supply to hold said hook and to close said door, said motor means being capable of powering said control unit when they are moving with no power, and said control unit being configured so that, in case of malfunction of said household appliance or of absence of power, said control unit being fed by said motor means, feeds said door-lock device for holding said door closed, until said member to be moved has a kinetic energy lower than a presettable threshold.
A dividing wall distillation column comprising: a first section having a tray that is a liquid barrier for collecting a first liquid; a second section disposed below the first section, the second section comprising two portions (28a, 28b) separated from each other by a dividing wall, wherein the liquid barrier of the first section is configured to block the first liquid from flowing from the first section into either of the two portions (28a, 28b) of the second section; and, a third section separated from the second section by a solid vapor and liquid barrier configured to block a flow of vapor from the third section to the second section and block a flow of liquid from the second section to the third section; a first vapor conduit providing vapor flow from the third section to a first portion of the second section; a second vapor conduit providing vapor flow from the third section to a second portion of the second section; and at least one liquid conduit (34a, 34b) for providing liquid from the second section to the third section; a first control valve disposed in the first vapor conduit; and, a second control valve disposed in the second vapor conduit; wherein the wall extends from the liquid barrier to the vapor and liquid barrier to provide the two portions (28a, 28b); wherein the first and second control valves (42a, 42b) are configured to operate independently of each other. a first section having a tray that is a liquid barrier for collecting a first liquid; a second section disposed below the first section, the second section comprising two portions (28a, 28b) separated from each other by a dividing wall, wherein the liquid barrier of the first section is configured to block the first liquid from flowing from the first section into either of the two portions (28a, 28b) of the second section; and, a third section separated from the second section by a solid vapor and liquid barrier configured to block a flow of vapor from the third section to the second section and block a flow of liquid from the second section to the third section; a first vapor conduit providing vapor flow from the third section to a first portion of the second section; a second vapor conduit providing vapor flow from the third section to a second portion of the second section; and at least one liquid conduit (34a, 34b) for providing liquid from the second section to the third section; a first control valve disposed in the first vapor conduit; and, a second control valve disposed in the second vapor conduit; wherein the wall extends from the liquid barrier to the vapor and liquid barrier to provide the two portions (28a, 28b); wherein the first and second control valves (42a, 42b) are configured to operate independently of each other.
A method for making an environmental barrier coating using a sintering aid comprising: combining at least water, and a primary transition material comprising mullite, or a mullite/BSAS mixture to produce a transition layer slurry; applying the transition layer slurry to a ceramic component; combining at least water, and a primary outer material comprising BSAS to produce an outer layer slurry; applying the outer layer slurry to the component having the applied transition layer slurry; and sintering the component to produce the environmental barrier coating having at least a transition layer and an outer layer wherein at least one of the transition layer slurry or the outer layer slurry comprises a slurry sintering aid, wherein the slurry sintering aid is selected from the group consisting of rare earth nitrate, rare earth acetate, rare earth chloride, rare earth oxide, ammonium phosphate, phosphoric acid, polyvinyl phosphonic acid, and combinations thereof, the slurry sintering aid exceeding the amount of slurry sintering aid soluble in the primary material of the at least one of the transition layer slurry or the outer layer slurry to leave a remaining insoluble portion of the slurry sintering aid, wherein the remaining insoluble portion reacts with the primary material of the least one of the transition layer slurry or the outer layer slurry to form a secondary material, and wherein the transition layer comprises a porosity of from 0% to 30% by volume of the transition layer, and the outer layer comprises a porosity of from 0% to 15% by volume of the outer layer. combining at least water, and a primary transition material comprising mullite, or a mullite/BSAS mixture to produce a transition layer slurry; applying the transition layer slurry to a ceramic component; combining at least water, and a primary outer material comprising BSAS to produce an outer layer slurry; applying the outer layer slurry to the component having the applied transition layer slurry; and sintering the component to produce the environmental barrier coating having at least a transition layer and an outer layer wherein at least one of the transition layer slurry or the outer layer slurry comprises a slurry sintering aid, wherein the slurry sintering aid is selected from the group consisting of rare earth nitrate, rare earth acetate, rare earth chloride, rare earth oxide, ammonium phosphate, phosphoric acid, polyvinyl phosphonic acid, and combinations thereof, the slurry sintering aid exceeding the amount of slurry sintering aid soluble in the primary material of the at least one of the transition layer slurry or the outer layer slurry to leave a remaining insoluble portion of the slurry sintering aid, wherein the remaining insoluble portion reacts with the primary material of the least one of the transition layer slurry or the outer layer slurry to form a secondary material, and wherein the transition layer comprises a porosity of from 0% to 30% by volume of the transition layer, and the outer layer comprises a porosity of from 0% to 15% by volume of the outer layer.
A chamber conveyor belt machine comprising a machine frame, a chamber cover with two columns and a lifting device, wherein a safety system is provided for the lifting device, characterized in that the safety system has a latching rail, which cooperates with a latching hook at at least one of the two columns, and in that the safety system has at least one first sensor in order to verify the open position of the latching rail or in order to verify the holding position, in which the latching hook engages the latching rail.