mhurhangee/ep-ind-claims huggingface dataset:
A nucleic acid template comprising: (a) a first guide strand comprising in 3' to 5' direction a first synthesis region, a second synthesis region, a first junction domain, and a first blocking region; and (b) a second guide strand comprising in 3' to 5' direction a second blocking region, a second junction domain and a third synthesis region, wherein the first junction domain comprises a nucleotide sequence substantially identical to a nucleotide sequence of the third synthesis region, and the first junction domain and second junction domain are substantially complementary to each other and form a double-stranded region, and wherein the first blocking region and the second blocking region together form a first blocking domain that blocks strand displacement activity of a polymerase. (a) a first guide strand comprising in 3' to 5' direction a first synthesis region, a second synthesis region, a first junction domain, and a first blocking region; and (b) a second guide strand comprising in 3' to 5' direction a second blocking region, a second junction domain and a third synthesis region, wherein the first junction domain comprises a nucleotide sequence substantially identical to a nucleotide sequence of the third synthesis region, and the first junction domain and second junction domain are substantially complementary to each other and form a double-stranded region, and wherein the first blocking region and the second blocking region together form a first blocking domain that blocks strand displacement activity of a polymerase.
A securing arrangement of a prosthetic hand on a forearm socket with a receiving frame that can be fixed to the forearm socket, the prosthetic hand being fixed to said receiving frame, characterized in that the receiving frame be designed to feature radially-directed openings, through which the securing elements protrude, wherein said securing elements positively engage with a proximal connection section of the prosthetic hand, wherein the connection section is fixed to a base body such that it can be detached.
A printing material mixing cartridge comprising: a reservoir to receive printing material from a printing apparatus and to return the received printing material to the printing apparatus; and a storage medium storing: a reservoir printing material level parameter indicative of the amount of printing material in the reservoir; a recirculation cycle counter indicative of the number of recirculation events experienced by the cartridge, wherein a recirculation event experienced by the cartridge comprises receiving printing material from the printing apparatus into the reservoir and returning the printing material from the reservoir to the printing apparatus; and a maximum recirculation cycle parameter indicative of the maximum number of recirculation events that may be experienced by the cartridge, wherein the reservoir printing material level parameter is rewritable by the printing apparatus, the maximum recirculation cycles parameter is read-only, and the recirculation cycle counter is not resettable and is a one directional counter updatable by the printing apparatus to indicate an updated number of recirculation events experienced by the cartridge. a reservoir to receive printing material from a printing apparatus and to return the received printing material to the printing apparatus; and a storage medium storing: a reservoir printing material level parameter indicative of the amount of printing material in the reservoir; a recirculation cycle counter indicative of the number of recirculation events experienced by the cartridge, wherein a recirculation event experienced by the cartridge comprises receiving printing material from the printing apparatus into the reservoir and returning the printing material from the reservoir to the printing apparatus; and a maximum recirculation cycle parameter indicative of the maximum number of recirculation events that may be experienced by the cartridge, wherein the reservoir printing material level parameter is rewritable by the printing apparatus, the maximum recirculation cycles parameter is read-only, and the recirculation cycle counter is not resettable and is a one directional counter updatable by the printing apparatus to indicate an updated number of recirculation events experienced by the cartridge.
A heat exchanger, in particular a rear evaporator for a motor vehicle, with tubes and a collecting tank which comprises a distributor plate, a baffle and a bottom plate, in which the tubes terminate with at least one of their ends, and which can be flowed through by refrigerant, characterised in that the collecting tank has exactly one opening in the distributor plate through which refrigerant passes into the collecting tank and directly after which the refrigerant flow is distributed between exactly two strands, wherein the refrigerant is evenly distributed between exactly two strands, wherein a distributor injection opening is formed in the baffle and wherein the distributor injection opening adjacent to the opening is H-shaped, wherein the two strands are respectively formed by at least one of the tubes to which the refrigerant can be supplied via the common H-shaped distributor injection opening.
A method for an online conference comprising: receiving an indication of a connection between an endpoint node in the network and a conferencing service; retrieving network data associated with the indicated connection between the endpoint node and the conferencing service; using a machine learning model to predict an experience metric for the endpoint node based on the retrieved network data associated with the indicated connection between the endpoint node and the conferencing service, wherein the machine learning model is trained based on user ratings provided by users on their experience of the conferencing service and on retrieved network data for the connections to the conferencing service that are associated with the user ratings provided by the users of the conferencing service; and causing the endpoint node to use a different connection to the conferencing service if the predicted experience metric for the indicated connection predicts a low quality user experience. receiving an indication of a connection between an endpoint node in the network and a conferencing service; retrieving network data associated with the indicated connection between the endpoint node and the conferencing service; using a machine learning model to predict an experience metric for the endpoint node based on the retrieved network data associated with the indicated connection between the endpoint node and the conferencing service, wherein the machine learning model is trained based on user ratings provided by users on their experience of the conferencing service and on retrieved network data for the connections to the conferencing service that are associated with the user ratings provided by the users of the conferencing service; and causing the endpoint node to use a different connection to the conferencing service if the predicted experience metric for the indicated connection predicts a low quality user experience.
A compound of formula having the structure: wherein: R 1 is selected from the group consisting of CH 2 COOH and CH 2 CH 2 COOH; R 2 is CH 3; and R3 is selected from the group consisting of 4-CH2CH3, and 4-CH 2. R 1 is selected from the group consisting of CH 2 COOH and CH 2 CH 2 COOH; R 2 is CH 3; and R3 is selected from the group consisting of 4-CH2CH3, and 4-CH 2.
An apparatus for injecting a fluid, comprising: a housing (110, 212, 414); a reservoir of pressurized fluid (120, 220, 420); a continuously variable pressure controller (150, 250) contained within the housing (110, 212, 414), the continuously variable pressure controller (150, 250) being in fluid communication with the reservoir of pressurized fluid (120, 220, 420) when the reservoir (120, 220, 420) is in an open state; an actuator (140, 240, 440) mechanically coupled to the pressure controller (150, 250), the actuator (140, 240, 440) being movable within a range along an axis of motion, the mechanical coupling of the actuator (140, 240, 440) to the pressure controller (150, 250) providing a linear relationship between displacement of the actuator (140, 240, 440) and a pressure regulated by the pressure controller (150, 250) for at least a portion of the range along the axis of motion, the mechanical coupling corresponding to a coupling for continuously varying a pressure regulated by the pressure controller (150, 250); a housing coupler (170, 270); and a housing sealing element (160, 260); wherein the provided linear relationship between displacement of the actuator (140, 240, 440) and a pressure regulated by the pressure controller (150, 250) comprises a linear relationship between displacement of the actuator (140, 240, 440) toward an initial position for at least a portion of the range along the axis of motion and a decrease in the pressure regulated by the pressure controller (150, 250). a housing (110, 212, 414); a reservoir of pressurized fluid (120, 220, 420); a continuously variable pressure controller (150, 250) contained within the housing (110, 212, 414), the continuously variable pressure controller (150, 250) being in fluid communication with the reservoir of pressurized fluid (120, 220, 420) when the reservoir (120, 220, 420) is in an open state; an actuator (140, 240, 440) mechanically coupled to the pressure controller (150, 250), the actuator (140, 240, 440) being movable within a range along an axis of motion, the mechanical coupling of the actuator (140, 240, 440) to the pressure controller (150, 250) providing a linear relationship between displacement of the actuator (140, 240, 440) and a pressure regulated by the pressure controller (150, 250) for at least a portion of the range along the axis of motion, the mechanical coupling corresponding to a coupling for continuously varying a pressure regulated by the pressure controller (150, 250); a housing coupler (170, 270); and a housing sealing element (160, 260); wherein the provided linear relationship between displacement of the actuator (140, 240, 440) and a pressure regulated by the pressure controller (150, 250) comprises a linear relationship between displacement of the actuator (140, 240, 440) toward an initial position for at least a portion of the range along the axis of motion and a decrease in the pressure regulated by the pressure controller (150, 250).
A compound of formula or a pharmaceutically acceptable salt thereof, for use in the treatment of a gastric cancer or a cancer selected from a cancer of the lung, a cancer of the breast, a cancer of the ovary and a cancer of the head and neck, wherein the compound of formula, or a pharmaceutically acceptable salt thereof, is administered to a patient in a daily dose of 100 mg to 450 mg for at least two five-consecutive day cycles, wherein said compound, or a pharmaceutically acceptable salt thereof, is not administered to the patient for a period of 2 days to 3 days between one five-consecutive day cycle and its subsequent five-consecutive day cycle.
A dilatation system for a medical device comprising a tubular portion and a dilating balloon at the distal end of the tubular portion, said dilatation system comprising an insertion element for preventing skin or tissue to be trapped between the distal end of the tubular portion and the proximal end of the deflated balloon, characterised in that the insertion element is located inside the dilating balloon and has a diameter increasing from its distal end to its proximal end.
A method comprising: providing a molten mixture of vesicle-forming lipids; and adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. providing a molten mixture of vesicle-forming lipids; and adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed.
A method of monitoring a machine, comprising: acquiring, by an acoustic sensor, acoustic signals from a vicinity of the machine, while the machine is operative; calculating, by a processor, a frequency spectrum of a segment of the acquired acoustic signals; determining boundaries of a frequency band to be analyzed; extracting, from the calculated frequency spectrum, a base frequency window in the determined boundaries, and one or more harmonics windows of harmonics of the boundaries of the base frequency window; determining for each of the base and harmonic windows a weight based on a distribution of values of frequencies in the windows; calculating, for each frequency in the base window, a weighted sum of a power of the frequency in the base window and of corresponding frequencies in the harmonic windows using the determined window weights; calculating a parameter of operation of the machine as a function of the calculated weighted sums; and evaluating operation of the machine, responsive to the calculated parameter; characterised in that determining a weight for each window comprises determining a frequency-domain entropy of the window. acquiring, by an acoustic sensor, acoustic signals from a vicinity of the machine, while the machine is operative; calculating, by a processor, a frequency spectrum of a segment of the acquired acoustic signals; determining boundaries of a frequency band to be analyzed; extracting, from the calculated frequency spectrum, a base frequency window in the determined boundaries, and one or more harmonics windows of harmonics of the boundaries of the base frequency window; determining for each of the base and harmonic windows a weight based on a distribution of values of frequencies in the windows; calculating, for each frequency in the base window, a weighted sum of a power of the frequency in the base window and of corresponding frequencies in the harmonic windows using the determined window weights; calculating a parameter of operation of the machine as a function of the calculated weighted sums; and evaluating operation of the machine, responsive to the calculated parameter; characterised in that determining a weight for each window comprises determining a frequency-domain entropy of the window.
Remotely operated vehicle for inspecting an environment having a potentially explosive atmosphere, comprising a power supply circuit for the vehicle, an explosive-atmosphere detector comprising an infrared gas detector, and a unit for controlling the power supply circuit, which unit is coupled to the explosive-atmosphere detector and to the power supply circuit, characterised in that the explosive-atmosphere detector includes a sensitivity selector making it possible to control a detection threshold on the basis of the gas which is suspected to have been detected, the control unit of the supply circuit being configured to cut off the supply circuit when the concentration of detected gas is greater than the detection threshold.
A drive unit for a hybrid electric vehicle, the drive unit including a transmission which is adapted to change the speed of rotation from an internal combustion engine, a differential device having a final driven gear to which power from the transmission is transmitted and distributing the power from the transmission to left and right drive axles (24L, 24R), a transmission case having a transmission housing part which houses the transmission and a differential housing part which is disposed behind, with respect to a forward direction of the vehicle, the transmission housing part and houses the differential device, and adapted to be located in front, with respect to the forward direction of the vehicle, of a dash panel and connected to that one end of the internal combustion engine which faces in a transverse direction of the vehicle, a rotary electric machine provided around the outer periphery of the transmission case, a speed reducer which is housed in a speed reducer case attached to the outer periphery of the transmission case and transmits power from the rotary electric machine to the final driven gear, and - an output gear which is housed in the differential housing part and meshing with the final driven gear, and which is connectable to the output shaft of the speed reducer, - wherein a sidewall (6a, 6b) of the transmission case has an opening through which the output shaft of the speed reducer extends, and wherein the speed reducer case is attached to the sidewall (6a, 6b) of the transmission case, the drive unit for the hybrid electric vehicle being characterized in that the output gear is disposed in front, with respect to the forward direction of the vehicle, of the final driven gear and at a lower level, with respect to an upward direction of the vehicle, than the final driven gear is; that the rotary electric machine is provided around the outer periphery of the transmission case in such a way that it is disposed in front, with respect to the forward direction of the vehicle, of the differential housing part; and that, with respect to a transverse direction of the vehicle at the differential housing part, the opening through which the output shaft of the speed reducer extends is arranged on the sidewall (6a, 6b) of the transmission case on the side opposite from the one where the internal combustion engine is located. - an output gear which is housed in the differential housing part and meshing with the final driven gear, and which is connectable to the output shaft of the speed reducer, - wherein a sidewall (6a, 6b) of the transmission case has an opening through which the output shaft of the speed reducer extends, and wherein the speed reducer case is attached to the sidewall (6a, 6b) of the transmission case,
A blade for a gas turbine engine comprising: an airfoil having a tip with a terminal end surface, and multiple squealer pockets (92, 94; 292, 194) recessed into the terminal end surface; wherein one of the squealer pockets (92, 292) includes a stepped bottom surface; wherein the terminal end surface provides a perimeter wall circumscribing the tip, the squealer pockets (92, 94; 292, 194) arranged interiorly of and surrounded by the perimeter wall; wherein the tip includes at least one intermediate wall interconnecting opposing sides of the perimeter wall and separating adjoining squealer pockets (92, 94; 292, 194); and wherein the squealer pockets (92, 94; 292, 194) have a depth of at least 0.5 mm (20 mils); wherein one of the squealer pockets (92; 292) is arranged near a leading edge of the airfoil, and the one of the squealer pocket (92, 292) has a first depth near the leading edge that is different than a second depth located aftward of the first depth; and the intermediate wall is configured to maintain cooling fluid within a forward squealer pocket to prevent migration of the cooling fluid to areas where it is not needed, such as more aftwardly located regions of the tip; characterized in that the tip has been formed by a casting process. an airfoil having a tip with a terminal end surface, and multiple squealer pockets (92, 94; 292, 194) recessed into the terminal end surface; wherein one of the squealer pockets (92, 292) includes a stepped bottom surface; wherein the terminal end surface provides a perimeter wall circumscribing the tip, the squealer pockets (92, 94; 292, 194) arranged interiorly of and surrounded by the perimeter wall; wherein the tip includes at least one intermediate wall interconnecting opposing sides of the perimeter wall and separating adjoining squealer pockets (92, 94; 292, 194); and wherein the squealer pockets (92, 94; 292, 194) have a depth of at least 0.5 mm (20 mils); wherein one of the squealer pockets (92; 292) is arranged near a leading edge of the airfoil, and the one of the squealer pocket (92, 292) has a first depth near the leading edge that is different than a second depth located aftward of the first depth; and the intermediate wall is configured to maintain cooling fluid within a forward squealer pocket to prevent migration of the cooling fluid to areas where it is not needed, such as more aftwardly located regions of the tip; characterized in that the tip has been formed by a casting process.
A cache address mapping method, wherein a cache comprises a plurality of cache sets, and the method comprises: obtaining a binary file (S101, S201), wherein the binary file comprises a first hot section, wherein a hot section is a section of the binary file which comprises one hot function, or a hot section is a section of the binary file which comprises a plurality of merged hot functions, and a hot function is a function code that frequently runs in a CPU; and wherein a non-hot section is a section of the binary file other than the hot section; and obtaining alignment information of a second hot section (S102,S202), wherein the second hot section is a hot section that has been loaded into the cache, and the alignment information comprises a set index of a last cache set occupied by the second hot section after the second hot section is loaded into the cache; the method further comprising performing an offset operation (S103,S203) on the first hot section based on the alignment information, so that the first hot section is mapped to cache sets with consecutive set indexes in the cache, and the cache sets with consecutive set indexes are adjacent to the last cache set occupied by the second hot section. obtaining a binary file (S101, S201), wherein the binary file comprises a first hot section, wherein a hot section is a section of the binary file which comprises one hot function, or a hot section is a section of the binary file which comprises a plurality of merged hot functions, and a hot function is a function code that frequently runs in a CPU; and wherein a non-hot section is a section of the binary file other than the hot section; and obtaining alignment information of a second hot section (S102,S202), wherein the second hot section is a hot section that has been loaded into the cache, and the alignment information comprises a set index of a last cache set occupied by the second hot section after the second hot section is loaded into the cache; the method further comprising performing an offset operation (S103,S203) on the first hot section based on the alignment information, so that the first hot section is mapped to cache sets with consecutive set indexes in the cache, and the cache sets with consecutive set indexes are adjacent to the last cache set occupied by the second hot section.
An enamel composition comprising a solid portion comprising a frit portion, the frit portion comprising, prior to firing: 30 to 50 wt% of SiO 2; 4.5 to 20.2 wt% of Cs 2 O; 6.1 to 11.5 wt% of Na 2 O; 6.5 to 20.2 wt% of B 2 O 3; 8 to 25 wt% of ZnO; 3.4 to 12.3 wt% of TiO 2; 0 to 40 wt% of Bi 2 O 3; and 0 to 7 wt% of F. 30 to 50 wt% of SiO 2; 4.5 to 20.2 wt% of Cs 2 O; 6.1 to 11.5 wt% of Na 2 O; 6.5 to 20.2 wt% of B 2 O 3; 8 to 25 wt% of ZnO; 3.4 to 12.3 wt% of TiO 2; 0 to 40 wt% of Bi 2 O 3; and 0 to 7 wt% of F.
An AAV vector for use in a method for the treatment of a motor neuron disorder in a subject in need thereof, wherein said vector is administered by peripheral administration of said AAV vector to said subject, said administration causing infection of motor neurons and expression of the gene in motor neurons, and wherein; said AAV vector comprises - a human AAV9 capsid; and - an AAV-2 derived genome comprising a gene of interest encoding a therapeutic product, said gene of interest being operably linked to a promoter specific or functional in motor neurons; wherein the gene encodes the "survival of motor neuron" protein; and wherein the motor neuron disorder is spinal muscular atrophy disorder. - a human AAV9 capsid; and - an AAV-2 derived genome comprising a gene of interest encoding a therapeutic product, said gene of interest being operably linked to a promoter specific or functional in motor neurons; wherein the gene encodes the "survival of motor neuron" protein; and wherein the motor neuron disorder is spinal muscular atrophy disorder. wherein the gene encodes the "survival of motor neuron" protein; and wherein the motor neuron disorder is spinal muscular atrophy disorder.