A process variable transmitter system for measuring a process variable, comprising: a process variable sensor configured to sense a process variable and provide a sensor output; measurement circuitry configured to receive the sensor output and provide a measured output related to the process variable; output circuitry configured to provide a device output on a two-wire process control loop based upon the measured output, the output circuitry having a transfer function that is a function of an adjustable zero setting analog circuit component and an adjustable span setting analog circuit component; a motorized zero setting actuator configured to receive a signal from a calibration controller related to a desired zero setting of the device output and to responsively adjust the adjustable zero setting analog circuit component to thereby change the transfer function of the output circuitry; a motorized span setting actuator configured to receive a signal from the calibration controller related to a desired span setting of the device output and to responsively adjust the adjustable span setting analog circuit component to thereby change the transfer function of the output circuitry; a transmitter housing, wherein the measurement circuitry, the motorized zero setting actuator, the motorized span setting actuator and output circuitry are located entirely in a hermetically sealed environment in the transmitter housing and wherein the calibration controller is outside the housing; and the calibration controller located externally the housing and connectable by wire to the motorized zero setting actuator and to the motorized span setting actuator, respectively. a process variable sensor configured to sense a process variable and provide a sensor output; measurement circuitry configured to receive the sensor output and provide a measured output related to the process variable; output circuitry configured to provide a device output on a two-wire process control loop based upon the measured output, the output circuitry having a transfer function that is a function of an adjustable zero setting analog circuit component and an adjustable span setting analog circuit component; a motorized zero setting actuator configured to receive a signal from a calibration controller related to a desired zero setting of the device output and to responsively adjust the adjustable zero setting analog circuit component to thereby change the transfer function of the output circuitry; a motorized span setting actuator configured to receive a signal from the calibration controller related to a desired span setting of the device output and to responsively adjust the adjustable span setting analog circuit component to thereby change the transfer function of the output circuitry; a transmitter housing, wherein the measurement circuitry, the motorized zero setting actuator, the motorized span setting actuator and output circuitry are located entirely in a hermetically sealed environment in the transmitter housing and wherein the calibration controller is outside the housing; and the calibration controller located externally the housing and connectable by wire to the motorized zero setting actuator and to the motorized span setting actuator, respectively.