A lithium battery protection circuit (300, 400, 500, 600) adapted to be coupled to a lithium battery, comprising: an over-charge protection circuit; a logic circuit (302, 15) coupled to the over-charge protection circuit and having a first logic output and a second logic output; a level shift circuit (306, 13) coupled to the logic circuit through the first logic output and the second logic output and configured to convert the first logic output and the second logic output to high voltage levels in an over-charge protection state; a substrate switching circuit (307, 14) coupled to the level shift circuit; and a power transistor coupled between a negative end of the lithium battery and an external circuit negative electrode (B-), characterized in that the lithium battery protection circuit comprises a system sleep circuit, wherein the logical circuit (302, 15) is coupled to the system sleep circuit and to the level shift circuit (306, 13) such that the logical circuit (302, 15) is adapted to control the system sleep circuit and the level shift circuit (306, 13); wherein the level shift circuit includes: a first inverter coupled to the second logic output; a plurality of PMOS transistors; and a plurality of NMOS transistors, wherein the level shift circuit is configured to control the power transistor via its gate terminal, the substrate switching circuit is coupled to the substrate of the power transistor and is configured to switch the voltage level of the substrate of the power transistor, wherein the lithium battery protection circuit further includes an excessive-current protection circuit; a short-circuit protection circuit, and a clamping circuit (308, 11), wherein the clamping circuit (308, 11) is coupled between the excessive-current protection circuit and the short-circuit protection circuit to the negative electrode to protect the excessive-current protection circuit and the short-circuit protection circuit from a high negative voltage on the negative electrode in the over-charge protection state. an over-charge protection circuit; a logic circuit (302, 15) coupled to the over-charge protection circuit and having a first logic output and a second logic output; a level shift circuit (306, 13) coupled to the logic circuit through the first logic output and the second logic output and configured to convert the first logic output and the second logic output to high voltage levels in an over-charge protection state; a substrate switching circuit (307, 14) coupled to the level shift circuit; and a power transistor coupled between a negative end of the lithium battery and an external circuit negative electrode (B-), characterized in that the lithium battery protection circuit comprises a system sleep circuit, wherein the logical circuit (302, 15) is coupled to the system sleep circuit and to the level shift circuit (306, 13) such that the logical circuit (302, 15) is adapted to control the system sleep circuit and the level shift circuit (306, 13); wherein the level shift circuit includes: a first inverter coupled to the second logic output; a plurality of PMOS transistors; and a plurality of NMOS transistors, wherein the level shift circuit is configured to control the power transistor via its gate terminal, the substrate switching circuit is coupled to the substrate of the power transistor and is configured to switch the voltage level of the substrate of the power transistor, wherein the lithium battery protection circuit further includes an excessive-current protection circuit; a short-circuit protection circuit, and a clamping circuit (308, 11), wherein the clamping circuit (308, 11) is coupled between the excessive-current protection circuit and the short-circuit protection circuit to the negative electrode to protect the excessive-current protection circuit and the short-circuit protection circuit from a high negative voltage on the negative electrode in the over-charge protection state. a first inverter coupled to the second logic output; a plurality of PMOS transistors; and a plurality of NMOS transistors, wherein the level shift circuit is configured to control the power transistor via its gate terminal, the substrate switching circuit is coupled to the substrate of the power transistor and is configured to switch the voltage level of the substrate of the power transistor, wherein the lithium battery protection circuit further includes an excessive-current protection circuit; a short-circuit protection circuit, and a clamping circuit (308, 11), wherein the clamping circuit (308, 11) is coupled between the excessive-current protection circuit and the short-circuit protection circuit to the negative electrode to protect the excessive-current protection circuit and the short-circuit protection circuit from a high negative voltage on the negative electrode in the over-charge protection state.