mhurhangee/ep-ind-claims huggingface dataset:
A method for producing bioengineered heart muscle from pluripotent stem cells, comprising the steps of (i) cultivating pluripotent stem cells in a basal medium comprising an effective amount of (a) BMP4, Activin A, FGF2, a GSK3-inhibitor, and (b) a serum-free supplement resulting in a final concentration of 0.5-50 mg/ml albumin, 1-100 μg/ml transferrin, 0.1-10 μg/ml ethanol amine, 0.003-0.3 μg/ml sodium selenite, 0.4-40 μg/ml L-Carnitine HCl, 0.1-10 μg/ml Hydrocortisone, 0.05-5 μl/ml Fatty acid supplement, 0.0001-0.1 μg/ml triodo-L-thyronine, thereby inducing mesoderm differentiation of said pluripotent stem cells; (ii) cultivating the cells obtained in step (i) in a basal medium comprising an effective amount of an inhibitor of the Wnt-signaling pathway and a serum-free supplement as in (i), thereby inducing cardiac differentiation of the cells; and (iii) cultivating the cells obtained in step (ii) in a basal medium comprising an effective amount of a serum-free supplement as in (i), under mechanical stimulation, thereby promoting cardiac maturation. (i) cultivating pluripotent stem cells in a basal medium comprising an effective amount of (a) BMP4, Activin A, FGF2, a GSK3-inhibitor, and (b) a serum-free supplement resulting in a final concentration of 0.5-50 mg/ml albumin, 1-100 μg/ml transferrin, 0.1-10 μg/ml ethanol amine, 0.003-0.3 μg/ml sodium selenite, 0.4-40 μg/ml L-Carnitine HCl, 0.1-10 μg/ml Hydrocortisone, 0.05-5 μl/ml Fatty acid supplement, 0.0001-0.1 μg/ml triodo-L-thyronine, thereby inducing mesoderm differentiation of said pluripotent stem cells; (ii) cultivating the cells obtained in step (i) in a basal medium comprising an effective amount of an inhibitor of the Wnt-signaling pathway and a serum-free supplement as in (i), thereby inducing cardiac differentiation of the cells; and (iii) cultivating the cells obtained in step (ii) in a basal medium comprising an effective amount of a serum-free supplement as in (i), under mechanical stimulation, thereby promoting cardiac maturation.
A gas evacuation system for evacuating gas from a gas-filled flexible bag, the bag having a length and a width and comprising opposing flexible side walls sealed at the edges and defining an interior volume therein and containing gas in the interior volume, the bag having a top end, a bottom end, and side ends, at least one conduit and at least one port arranged at the bottom end or the top end, wherein the port is in fluid communication with the interior volume and the conduit, the system comprising (a) a flexible polymeric sheet having a density of at least about 3 Kg/m 2, a sheet top end, a sheet bottom end, and sheet side ends, and a length and a width to substantially cover one of the flexible side walls of the bag, said density of the flexible sheet being sufficient to compress and evacuate the gas-filled flexible bag when the flexible sheet is placed on the wall of the gas-filled bag; and, (b) a flexible bag receiving device, the receiving device comprising a base and at least one raised wall, and having a length and width greater than the length and width of the flexible bag; wherein one end of the polymeric flexible sheet is secured to the receiving device. (a) a flexible polymeric sheet having a density of at least about 3 Kg/m 2, a sheet top end, a sheet bottom end, and sheet side ends, and a length and a width to substantially cover one of the flexible side walls of the bag, said density of the flexible sheet being sufficient to compress and evacuate the gas-filled flexible bag when the flexible sheet is placed on the wall of the gas-filled bag; and, (b) a flexible bag receiving device, the receiving device comprising a base and at least one raised wall, and having a length and width greater than the length and width of the flexible bag; wherein one end of the polymeric flexible sheet is secured to the receiving device.
A clamped bonnet assembly for an axial flow control valve with a valve body, the clamped bonnet assembly comprising: a clamped bonnet, having a cylindrical body, a first end, a second end and a hollow bore, wherein the clamped bonnet is at least partially disposable within an opening of the valve body such that the second end is locatable within the valve body; a valve seat comprising external threads configured to threadably engage the valve body such that rotation of the valve seat provides a force through a cage to secure the clamped bonnet, wherein the cage is disposed directly between the clamped bonnet and the valve seat, the cage abutting the clamped bonnet at one end and the valve seat at another end; a packing disposed within one end of the hollow bore; and a packing follower within the one end of the hollow bore, the packing follower containing the packing within the hollow bore; wherein the first end of the clamped bonnet comprises an inner threaded portion and the packing follower comprises an outer threaded portion which cooperates with the inner threaded portion to releasably secure the packing follower to the clamped bonnet wherein the first end of the clamped bonnet is configured such that the packing follower is adjustable within the clamped bonnet from outside a valve body. a clamped bonnet, having a cylindrical body, a first end, a second end and a hollow bore, wherein the clamped bonnet is at least partially disposable within an opening of the valve body such that the second end is locatable within the valve body; a valve seat comprising external threads configured to threadably engage the valve body such that rotation of the valve seat provides a force through a cage to secure the clamped bonnet, wherein the cage is disposed directly between the clamped bonnet and the valve seat, the cage abutting the clamped bonnet at one end and the valve seat at another end; a packing disposed within one end of the hollow bore; and a packing follower within the one end of the hollow bore, the packing follower containing the packing within the hollow bore; wherein the first end of the clamped bonnet comprises an inner threaded portion and the packing follower comprises an outer threaded portion which cooperates with the inner threaded portion to releasably secure the packing follower to the clamped bonnet wherein the first end of the clamped bonnet is configured such that the packing follower is adjustable within the clamped bonnet from outside a valve body.
Method for determining a setpoint steering torque (torSSW) for a steering means of a steering device in a vehicle, in which an actual toothed rack force (forRT) is determined, and in which at least a first component for the setpoint steering torque (torSSW) is determined as a function of the actual toothed rack force (forRT), characterized in that at least one additional component for the setpoint steering torque (torSSW) is determined, wherein the additional component is determined from a calculated toothed rack force (forRS) and the calculated toothed rack force (forRS) is determined at least from a steering wheel angle and a vehicle velocity (velV), and wherein the additional component makes a variable contribution to the setpoint steering torque (torSS) only in a centre region of the steering device, and furthermore assumes a fixed value.
A device for measuring a position of a toe tip of a walking user, the device comprising: a data acquisition unit configured to acquire, from a depth sensor disposed so as to capture an image of a walking path set in advance and a space above the walking path and outputting image data having a depth of each pixel added thereto, image data for a state in which there is no user on the walking path as reference data and image data for a state in which a user is walking on the walking path as walking data; a specific pixel extraction unit configured to find a difference between the walking data and the reference data, to identify the leg of the user located closer to the depth sensor from the difference that has been found and a depth included in the difference, and furthermore to extract, from pixels constituting the identified leg, a pixel of a toe tip part on the basis of the depth; and a position calculation unit configured to calculate three-dimensional coordinates of the pixel from coordinates of the extracted pixel in the image data and the depth of the extracted pixel, and to take the calculated three-dimensional coordinates as the position of the toe tip of the user. a data acquisition unit configured to acquire, from a depth sensor disposed so as to capture an image of a walking path set in advance and a space above the walking path and outputting image data having a depth of each pixel added thereto, image data for a state in which there is no user on the walking path as reference data and image data for a state in which a user is walking on the walking path as walking data; a specific pixel extraction unit configured to find a difference between the walking data and the reference data, to identify the leg of the user located closer to the depth sensor from the difference that has been found and a depth included in the difference, and furthermore to extract, from pixels constituting the identified leg, a pixel of a toe tip part on the basis of the depth; and a position calculation unit configured to calculate three-dimensional coordinates of the pixel from coordinates of the extracted pixel in the image data and the depth of the extracted pixel, and to take the calculated three-dimensional coordinates as the position of the toe tip of the user.
A signaling radio bearer, SRB, transmission method performed by an SRB transmission device, said method comprising: applying, according to configuration, radio link control, RLC, layer unacknowledged mode, UM, for all or part of SRB data, wherein the applying, according to configuration, RLC layer UM mode for all or part of SRB data comprises: indicating, at a radio resource control, RRC layer, the SRB data applying the RLC layer UM mode by filling, in a packet header of the SRB data, identification information on applying the RLC layer UM mode, and transferring the identification information to a RLC layer via a packet data convergence protocol, PDCP, layer, determining, by the PDCP layer, that the SRB data needs to apply the RLC layer UM mode according to the identification information carried in the packet header of the SRB data, and performing, at the PDCP layer, repeated transmission on the SRB data applying the RLC layer UM mode. applying, according to configuration, radio link control, RLC, layer unacknowledged mode, UM, for all or part of SRB data, wherein the applying, according to configuration, RLC layer UM mode for all or part of SRB data comprises: indicating, at a radio resource control, RRC layer, the SRB data applying the RLC layer UM mode by filling, in a packet header of the SRB data, identification information on applying the RLC layer UM mode, and transferring the identification information to a RLC layer via a packet data convergence protocol, PDCP, layer, determining, by the PDCP layer, that the SRB data needs to apply the RLC layer UM mode according to the identification information carried in the packet header of the SRB data, and performing, at the PDCP layer, repeated transmission on the SRB data applying the RLC layer UM mode.
Method for processing a message received via an electronic communication network by a user terminal, the method comprising: receiving the message (S3, S3'), said message comprising: - data corresponding to initial message content determined by the sender of the message; and - at least one datum corresponding to a function, the at least one datum being determined by the sender of the message; determining final content (S5, S5'), said final content comprising: - the initial message content determined by the sender of the message; and - specific content obtained by determining a result of the function applied to at least data present on the user terminal. receiving the message (S3, S3'), said message comprising: - data corresponding to initial message content determined by the sender of the message; and - at least one datum corresponding to a function, the at least one datum being determined by the sender of the message; - data corresponding to initial message content determined by the sender of the message; and - at least one datum corresponding to a function, the at least one datum being determined by the sender of the message; determining final content (S5, S5'), said final content comprising: - the initial message content determined by the sender of the message; and - specific content obtained by determining a result of the function applied to at least data present on the user terminal. - the initial message content determined by the sender of the message; and - specific content obtained by determining a result of the function applied to at least data present on the user terminal.
A personal care composition comprising a sodium lauryl ether sulfate 1EO surfactant and 0.1 to 0.8 wt percent of an insoluble manganese and/or copper piroctone complex, the insoluble manganese and/or copper piroctone complex having a solubility of 2wt percent or less in a 5wt percent aqueous sodium lauryl ether sulfate 1EO surfactant solution at 20 degrees centigrade.
A method for controlling the use of applications running on items of communication equipment (2 j), belonging to users having access to a private network comprising a licence server arranged for managing the licences of applications that are authorized to be used by said items of user communication equipment (2 j), when they are connected to said private network, said method comprising a step comprising, - upon detection that an item of user communication equipment (2 j) has established a connection with said private network, forbidding the use of each application of this user communication equipment (2 j); - after the use of each application of this user communication equipment is forbidden, triggering a determination in an authorization server of said private network of the applications of said user communication equipment (2 j) that are authorized to be used by the latter; - after determination of the applications of said user communication equipment (2 j) that are authorized to be used, authorizing the use by said user communication equipment (2 j) of the applications authorized by said authorization server. - upon detection that an item of user communication equipment (2 j) has established a connection with said private network, forbidding the use of each application of this user communication equipment (2 j); - after the use of each application of this user communication equipment is forbidden, triggering a determination in an authorization server of said private network of the applications of said user communication equipment (2 j) that are authorized to be used by the latter; - after determination of the applications of said user communication equipment (2 j) that are authorized to be used, authorizing the use by said user communication equipment (2 j) of the applications authorized by said authorization server.
A sustained release pharmaceutical composition comprising a compound selected from the group consisting of 2,4-dinitrophenol, a salt thereof, a solvate thereof, and any combinations thereof, for use in preventing or treating in a subject in need thereof a disease or disorder selected from the group consisting of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic steatosis, type 2 diabetes (T2D), acquired lipodystrophy, (inherited) lipodystrophy, partial lipodystrophy, hypertriglyceridemia, obesity, metabolic syndrome, Rett's syndrome, metabolic syndrome associated with aging, Friedreich's ataxia, insulin resistance, hepatic fibrosis, liver cirrhosis and hepatocellular carcinoma, wherein the composition is administered orally, wherein a therapeutically effective dose of the compound ranging from 1 mg/kg/day to 10 mg/kg/day is administered, and wherein the administration of the composition affords a steady state plasma concentration of the compound ranging from 0.5 μM to 50 μM in the subject and wherein the compound is present in therapeutically effective levels in the subject for a period of time ranging from 12 hours to 24 hours. for use in preventing or treating in a subject in need thereof a disease or disorder selected from the group consisting of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic steatosis, type 2 diabetes (T2D), acquired lipodystrophy, (inherited) lipodystrophy, partial lipodystrophy, hypertriglyceridemia, obesity, metabolic syndrome, Rett's syndrome, metabolic syndrome associated with aging, Friedreich's ataxia, insulin resistance, hepatic fibrosis, liver cirrhosis and hepatocellular carcinoma, wherein the composition is administered orally, wherein a therapeutically effective dose of the compound ranging from 1 mg/kg/day to 10 mg/kg/day is administered, and wherein the administration of the composition affords a steady state plasma concentration of the compound ranging from 0.5 μM to 50 μM in the subject and wherein the compound is present in therapeutically effective levels in the subject for a period of time ranging from 12 hours to 24 hours.
A computer program for managing power requirements of mobile refrigeration units, the refrigeration units being in use attached to a trailer or vehicle to cool an interior space thereof during a journey and being powered by one or more rechargeable batteries and optionally one or more solar panels, the computer program comprising processor readable instructions, which when executed by the processer cause the computer to: receive at least an itinerary for an upcoming journey of the refrigeration unit and set point temperature to be achieved and maintained by the refrigeration unit for cooling the interior space for that journey; model the energy requirements to achieve the set point temperature for the journey, and determine a battery charge level for the one or more batteries to provide that energy, wherein the computer program is arranged to receive historical usage data from refrigeration units during journeys, the data including said one or more parameters and data indicating the actual temperature achieved by the refrigeration units and energy consumption of the refrigeration units, which data is used to train Digital Twin models of the performance of respective individual refrigeration units via machine learning algorithms and wherein the model for the particular refrigeration unit that is making the upcoming journey is used in said determination of the battery charge level; and in accordance with the determination, to output a control signal to the refrigeration unit to cause the required batteries to be charged to the required level. receive at least an itinerary for an upcoming journey of the refrigeration unit and set point temperature to be achieved and maintained by the refrigeration unit for cooling the interior space for that journey; model the energy requirements to achieve the set point temperature for the journey, and determine a battery charge level for the one or more batteries to provide that energy, wherein the computer program is arranged to receive historical usage data from refrigeration units during journeys, the data including said one or more parameters and data indicating the actual temperature achieved by the refrigeration units and energy consumption of the refrigeration units, which data is used to train Digital Twin models of the performance of respective individual refrigeration units via machine learning algorithms and wherein the model for the particular refrigeration unit that is making the upcoming journey is used in said determination of the battery charge level; and in accordance with the determination, to output a control signal to the refrigeration unit to cause the required batteries to be charged to the required level.
A bracket assembly for coupling a controller and an actuator, comprising: a bracket having a first side and a second side opposite the first side, the first side of the bracket defines ribs that intersect to form a web-like pattern such that the ribs and a recessed surface of the first side define a plurality of cavities, the first side configured to be coupled to a first surface of an actuator, and the second side configured to be coupled to a controller; and a first accelerometer coupled to the first side of the bracket, the first accelerometer housed within a first cavity of the plurality of cavities formed in the bracket, wherein, when a coupling is formed between the first side of the bracket and a first surface of an actuator, the first accelerometer is arranged to determine a first acceleration value of a portion of the bracket adjacent a coupling, the first acceleration value indicative of a degree to which the bracket is securely coupled to an actuator. a bracket having a first side and a second side opposite the first side, the first side of the bracket defines ribs that intersect to form a web-like pattern such that the ribs and a recessed surface of the first side define a plurality of cavities, the first side configured to be coupled to a first surface of an actuator, and the second side configured to be coupled to a controller; and a first accelerometer coupled to the first side of the bracket, the first accelerometer housed within a first cavity of the plurality of cavities formed in the bracket, wherein, when a coupling is formed between the first side of the bracket and a first surface of an actuator, the first accelerometer is arranged to determine a first acceleration value of a portion of the bracket adjacent a coupling, the first acceleration value indicative of a degree to which the bracket is securely coupled to an actuator.
A vacuum chamber for a flywheel device comprising: an enclosure, with a vertical axis, having a top and a bottom; a plate fastened to the top of the enclosure, wherein the plate includes a first opening; and a vacuum cap, comprising a top side and a bottom side, which is fastened to the plate and forms a seal between the bottom side and the first opening, characterised in that the vacuum cap bottom side comprises: an o-ring groove in the vacuum cap bottom side configured to hold an o-ring; a grease channel in the vacuum cap bottom side, concentric with the o-ring groove, configured to hold grease to reduce permeation of gas into the vacuum chamber; an inlet port connecting the top side of the vacuum cap to the grease channel, which enables grease to be injected into the grease channel; and an outlet port connecting the top side of the vacuum cap to the grease channel, which enables gases to escape from the grease channel. an enclosure, with a vertical axis, having a top and a bottom; a plate fastened to the top of the enclosure, wherein the plate includes a first opening; and a vacuum cap, comprising a top side and a bottom side, which is fastened to the plate and forms a seal between the bottom side and the first opening, characterised in that the vacuum cap bottom side comprises: an o-ring groove in the vacuum cap bottom side configured to hold an o-ring; a grease channel in the vacuum cap bottom side, concentric with the o-ring groove, configured to hold grease to reduce permeation of gas into the vacuum chamber; an inlet port connecting the top side of the vacuum cap to the grease channel, which enables grease to be injected into the grease channel; and an outlet port connecting the top side of the vacuum cap to the grease channel, which enables gases to escape from the grease channel. an o-ring groove in the vacuum cap bottom side configured to hold an o-ring; a grease channel in the vacuum cap bottom side, concentric with the o-ring groove, configured to hold grease to reduce permeation of gas into the vacuum chamber; an inlet port connecting the top side of the vacuum cap to the grease channel, which enables grease to be injected into the grease channel; and an outlet port connecting the top side of the vacuum cap to the grease channel, which enables gases to escape from the grease channel.