A method of displaying images of a lumen acquired using an optical coherence tomography imaging modality, the method comprising the steps of: generating an axial scan region including an axial slice of an image of the lumen; generating an axial zoom region, the axial zoom region including an enlarged axial slice of a first portion of the image of the lumen; generating a longitudinal scan region including a longitudinal slice of the image, wherein the longitudinal slice corresponds to the axial slice; generating a longitudinal zoom region, the longitudinal zoom region including an enlarged longitudinal slice of the first portion of the image of the lumen; displaying the axial scan region, the longitudinal scan region, the axial zoom region, and the longitudinal zoom region on a display device; overlaying a first window on a portion of the axial scan region; overlaying a second window on a portion of the longitudinal scan region; wherein the portion of the axial scan region and the portion of the longitudinal scan region correspond to the first portion of the image displayed in the axial zoom region and the longitudinal zoom region; and the method further comprising: either receiving an input including an indication of a movement of the first window and adjusting the position of the second window based on the movement of the first window or receiving an input including an indication of a movement of the second window and adjusting the position of the first window based on the movement of the second window; updating the enlarged axial slice displayed in the axial zoom region based on the movement of the first window; and updating the enlarged longitudinal slice displayed in the longitudinal zoom region based on a movement of the second window. generating an axial scan region including an axial slice of an image of the lumen; generating an axial zoom region, the axial zoom region including an enlarged axial slice of a first portion of the image of the lumen; generating a longitudinal scan region including a longitudinal slice of the image, wherein the longitudinal slice corresponds to the axial slice; generating a longitudinal zoom region, the longitudinal zoom region including an enlarged longitudinal slice of the first portion of the image of the lumen; displaying the axial scan region, the longitudinal scan region, the axial zoom region, and the longitudinal zoom region on a display device; overlaying a first window on a portion of the axial scan region; overlaying a second window on a portion of the longitudinal scan region; wherein the portion of the axial scan region and the portion of the longitudinal scan region correspond to the first portion of the image displayed in the axial zoom region and the longitudinal zoom region; and the method further comprising: either receiving an input including an indication of a movement of the first window and adjusting the position of the second window based on the movement of the first window or receiving an input including an indication of a movement of the second window and adjusting the position of the first window based on the movement of the second window; updating the enlarged axial slice displayed in the axial zoom region based on the movement of the first window; and updating the enlarged longitudinal slice displayed in the longitudinal zoom region based on a movement of the second window. either receiving an input including an indication of a movement of the first window and adjusting the position of the second window based on the movement of the first window or receiving an input including an indication of a movement of the second window and adjusting the position of the first window based on the movement of the second window; updating the enlarged axial slice displayed in the axial zoom region based on the movement of the first window; and updating the enlarged longitudinal slice displayed in the longitudinal zoom region based on a movement of the second window.