mhurhangee/ep-ind-claims huggingface dataset:
An introducer needle device, comprising a needle housing, a needle, and a resilient means; the needle comprising a needle hub at one end and a bevelled needle tip at another end housed at least partially within the needle housing; the needle housing including indicia that comprises a means for identifying an angular orientation of the bevelled needle tip within the needle housing; the needle being movable axially along a length of the needle housing between a first position relative to the needle housing in which the needle tip is contained within the needle housing and a second position relative to the needle housing in which at least a part of the needle tip extends beyond a periphery of the needle housing; the resilient means being arranged to bias the needle towards and into the first position and being compressible to enable movement of the needle towards and into the second position; wherein the device further comprises means for preventing rotation of the needle within the needle housing; and the needle housing further comprises a coupling means for coupling the introducer needle device to a separate component, wherein each of the coupling means and the separate component comprises a luer hub fitting, the coupling means being arranged relative to the needle such that coupling of the separate component to the coupling means causes the separate component to engage and move the needle hub so that the resilient means are compressed and the needle is moved towards and arranged in the second position. the needle comprising a needle hub at one end and a bevelled needle tip at another end housed at least partially within the needle housing; the needle housing including indicia that comprises a means for identifying an angular orientation of the bevelled needle tip within the needle housing; the needle being movable axially along a length of the needle housing between a first position relative to the needle housing in which the needle tip is contained within the needle housing and a second position relative to the needle housing in which at least a part of the needle tip extends beyond a periphery of the needle housing; the resilient means being arranged to bias the needle towards and into the first position and being compressible to enable movement of the needle towards and into the second position; wherein the device further comprises means for preventing rotation of the needle within the needle housing; and the needle housing further comprises a coupling means for coupling the introducer needle device to a separate component, wherein each of the coupling means and the separate component comprises a luer hub fitting, the coupling means being arranged relative to the needle such that coupling of the separate component to the coupling means causes the separate component to engage and move the needle hub so that the resilient means are compressed and the needle is moved towards and arranged in the second position.
A cutting tool key suitable for mounting and extracting a cutting insert into and from an insert receiving slot of a cutting tool holder blade, the key comprising: a handle having a longitudinally extending handle axis; a protrusion connected to the handle and protruding in a first direction transverse to the handle axis, the protrusion having a peripheral surface and being elongated along a main protrusion axis transverse to the first direction in which the protrusion protrudes, the protrusion comprising first and second engagement portions (82, 84) and a connecting neck portion arranged along the main protrusion axis; a pivot axis formed in the first engagement portion, the pivot axis intersecting the main protrusion axis and being transverse to the handle axis; wherein: the first and second engagement portions (82, 84) and the connecting neck portion have unitary one-piece construction, share the peripheral surface of the protrusion and are fixed relative to the handle axis; characterised in that the protrusion has two identical protrusion wavy contours, each wavy contour including two wide sections, corresponding to the first and second engagement portions (82, 84), coupled by a narrower section, corresponding to the connecting neck portion. a handle having a longitudinally extending handle axis; a protrusion connected to the handle and protruding in a first direction transverse to the handle axis, the protrusion having a peripheral surface and being elongated along a main protrusion axis transverse to the first direction in which the protrusion protrudes, the protrusion comprising first and second engagement portions (82, 84) and a connecting neck portion arranged along the main protrusion axis; a pivot axis formed in the first engagement portion, the pivot axis intersecting the main protrusion axis and being transverse to the handle axis; the first and second engagement portions (82, 84) and the connecting neck portion have unitary one-piece construction, share the peripheral surface of the protrusion and are fixed relative to the handle axis; characterised in that the protrusion has two identical protrusion wavy contours, each wavy contour including two wide sections, corresponding to the first and second engagement portions (82, 84), coupled by a narrower section, corresponding to the connecting neck portion.
A method of enhancing transcription of at least one transgene in a lentiviral expression vector comprising introducing a stuffer nucleotide sequence inserted in place of a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) downstream of the transgene, wherein the expression of the transgene is higher when the SNS is inserted in place of the WPRE as compared to the WPRE, and wherein the SNS is selected from the group consisting of SEQ ID Nos: 1, 2, 4, 6 and 7, wherein the transgene is under the control of an EF1α promoter, and wherein the transgene is expressed in T cells
Electron microscope with an electron source and at least one objective lens, the electron microscope being equipped with at least one phase plate (8, 8a-h), the phase plate (8, 8a-h) consisting of at least one thin film (8, 8a-h), which is permeable to electron beams at least in part and is made from electrically conductive material, being connected to a voltage source (12, 12a-e) for applying a predeterminable electric voltage and has at least one through-hole (9, 9a-c), characterised in that the through-hole (9, 9a-c) is positioned close to a focal plane, which is to the rear in relation to an object to be observed, of the objective lens, in which back focal plane a bundle of unscattered electron beams collected by the objective lens experiences minimal spread perpendicular to an optical axis such that a central beam of unscattered electrons is guided through the through-hole, the voltage applied to the phase plate (8, 8a-h) by means of the voltage source (12, 12a-e) being different from a voltage at the outlet of the electron source of the electron microscope.
Ball joint having a ball pivot which is received in a ball socket, which ball socket is received in a joint housing, the ball socket being configured in one piece with at least one spring element in a lower region of the ball socket, which region faces away from the joint housing opening, the spring element being configured in such a way that, in the pre-assembled state, an intermediate space is situated between an inner wall of the housing and the ball socket and, in the assembled state, the spring element is prestressed, in order to generate a prestress in the ball joint, the spring element having, at least in part, interruptions which are formed by way of slots, with the result that the spring element provides play compensation and/or wear compensation within the ball joint, and the at least one spring element having a first region and a second region which adjoins it at the bottom, the at least one spring element being of wedge-shaped configuration in the first and in the second region (9a, 9b), the wall thickness of the ball socket increasing downwards in the first region as far as the beginning of the second region and decreasing in the second region towards its lower end starting from the lower end of the first region.
A flexible package (14; 114) comprising one or more lengths of flexible material (16; 116) arranged to define an internal cavity closed by means of one or more seals (18, 22, 24; 170,172) in which opposed regions of the material are bonded together, the package having opposed tab portions (32; 132) in which the material is not bonded to an opposing region of material associated with one of said seals (22; 172), the material having directional tear characteristics and being orientated so as to tear preferentially in a direction substantially orthogonal to the direction of said seal (22; 172) with which the tab portions (32; 132) are associated; wherein said seal (22; 172) is a peelable seal and in that a tab region (30; 132) is defined within said seal, the opposed regions of material within the tab region being bonded together only over an inner extent of said seal (22; 172), whilst the opposed regions of material within the tab region (30; 132) but outside the inner extent are not bonded together to at least partially define the opposed tab portions (32; 132); characterised in that the material (16; 116) consists exclusively of a single layer of monoaxially orientated polypropylene film.
A method for producing a conjugated diene characterized in that it comprises a step of enzymatically converting a compound of the general formula C n H 2n O into C n H 2n-2 + H 2 O, with 3 < n < 7, by making use of a linalool dehydratase-isomerase (EC 4.2.1.127).
A therapeutic agent for use in a method of treating undifferentiated gastric cancer, which agent comprises (i) a compound I, a pharmacologically acceptable salt thereof or a solvate thereof, in combination with (ii) a therapeutic substance for gastric cancer which is irinotecan or paclitaxel; wherein the compound I, a pharmacologically acceptable salt thereof or a solvate thereof is at least one compound selected from the group consisting of: 4-((3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; 4-((3-chloro-4-(ethylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; N6-methoxy-4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide; 4-((3-chloro-4-(methylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; and N6-methoxy-4-(3-chloro-4-(((ethylamino)carbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide, a pharmacologically acceptable salt thereof or a solvate thereof. 4-((3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; 4-((3-chloro-4-(ethylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; N6-methoxy-4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide; 4-((3-chloro-4-(methylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; and N6-methoxy-4-(3-chloro-4-(((ethylamino)carbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide,
Drive mechanism for a drug delivery device, the drive mechanism comprising: - a housing having a proximal end and a distal end, - a piston rod having a longitudinal axis (x) and a piston rod feature, - a drive member being movable with respect to the housing, the drive member comprising a drive feature, the drive member being radially movable perpendicular to the piston rod between a first and a second position, wherein the drive feature is selectively engageable with the piston rod feature by the radial displacement of the drive member with respect to the piston rod, the drive mechanism being configured such that: - when the drive member is in the first position, the drive member is disengaged from the piston rod and movable with respect to the piston rod, and - when the drive member is in the second position, the drive feature is engaged with the piston rod feature such that, when the drive member moves distally with respect to the housing, said distal movement is transferred to the piston rod such that the piston rod moves distally with respect to the housing, wherein the drive mechanism comprises a coupling element being fixed to or formed integrally with the housing, the coupling element further comprises a plurality of axially spaced coupling features (20a, b, c) each of which being configured to establish a unidirectional coupling with the piston rod feature such that a proximal movement of the piston rod with respect to the housing is prevented. - a housing having a proximal end and a distal end, - a piston rod having a longitudinal axis (x) and a piston rod feature, - a drive member being movable with respect to the housing, the drive member comprising a drive feature, the drive member being radially movable perpendicular to the piston rod between a first and a second position, wherein the drive feature is selectively engageable with the piston rod feature by the radial displacement of the drive member with respect to the piston rod, the drive mechanism being configured such that: - when the drive member is in the first position, the drive member is disengaged from the piston rod and movable with respect to the piston rod, and - when the drive member is in the second position, the drive feature is engaged with the piston rod feature such that, when the drive member moves distally with respect to the housing, said distal movement is transferred to the piston rod such that the piston rod moves distally with respect to the housing, - when the drive member is in the first position, the drive member is disengaged from the piston rod and movable with respect to the piston rod, and - when the drive member is in the second position, the drive feature is engaged with the piston rod feature such that, when the drive member moves distally with respect to the housing, said distal movement is transferred to the piston rod such that the piston rod moves distally with respect to the housing,
A method for obtaining a reference signal, comprising: determining, based on a resource that is allocated to a reference signal in a basic pattern corresponding to the reference signal and a resource that is allocated to at least one basic pattern in a physical layer transmission unit, a resource occupied by the reference signal in the physical layer transmission unit; and obtaining the reference signal through the determined resource, wherein the method further comprises: receiving information that indicates the resource that is allocated to the at least one basic pattern in the physical layer transmission unit, and the information is transmitted through radio resource control, RRC, signaling. determining, based on a resource that is allocated to a reference signal in a basic pattern corresponding to the reference signal and a resource that is allocated to at least one basic pattern in a physical layer transmission unit, a resource occupied by the reference signal in the physical layer transmission unit; and obtaining the reference signal through the determined resource, wherein the method further comprises: receiving information that indicates the resource that is allocated to the at least one basic pattern in the physical layer transmission unit, and the information is transmitted through radio resource control, RRC, signaling.
Component of a hydroelectric turbine with a wedge-shaped substrate and an erosion-resistant coating covering the substrate, wherein the substrate comprises a base body and a tip section seated thereon, which forms an armouring of the component against erosion damage, and wherein the tip section terminates in a tip, and wherein the tip section consists of a metallic matrix in which particles of a very hard material are embedded, and wherein the thickness of the coating at the tip of the tip section is D 1, and wherein the height of the tip section is H, and wherein H≥ D 1, characterised in that the tip section is joined to the base body by one of the following build-up welding processes, so that the matrix of the tip section forms an intercrystalline bond with the base body: - Laser powder welding, wherein the powder is a mixture of the particles and the powdery material of the matrix; - manual laser welding, wherein a welding wire is used which is designed as a hollow wire, and wherein the sheath of the wire is formed from the material of the matrix, and the particles are arranged inside the sheath - Laser powder welding, wherein the powder is a mixture of the particles and the powdery material of the matrix; - manual laser welding, wherein a welding wire is used which is designed as a hollow wire, and wherein the sheath of the wire is formed from the material of the matrix, and the particles are arranged inside the sheath
A refrigeration system, comprising a compressor, an outdoor heat exchanger, an expansion valve capable of being fully closed, and an indoor heat exchanger, which are connected to one another by a refrigerant pipe, which is applied to a cooling only system, in which a circulation direction of refrigerant is constant, a receiver provided upstream of the expansion valve, characterized in that the refrigeration system further comprises: a receiver provided upstream of the expansion valve; a gas vent passageway for connecting the receiver and a downstream side pipe of the expansion valve to each other; gas vent opening/closing means provided along the gas vent passageway; and backflow preventing means provided upstream of the receiver for allowing only a refrigerant flow running from the outdoor heat exchanger to the receiver, or auxiliary opening/closing means provided upstream of the receiver and being always opened during a normal operation, wherein: at least a path extending from the backflow preventing means or the auxiliary opening/closing means to the expansion valve via the receiver, and a path along the gas vent passageway extending from the receiver to the gas vent opening/closing means are provided on an outdoor side; and the refrigeration system further comprises control means which, before shutting down the compressor, opens the gas vent opening/closing means and closes the expansion valve while the compressor is left operating, and which closes the gas vent opening/closing means, or closes the gas vent opening/closing means and the auxiliary opening/closing means upon subsequent shut down of the compressor. a receiver provided upstream of the expansion valve; a gas vent passageway for connecting the receiver and a downstream side pipe of the expansion valve to each other; gas vent opening/closing means provided along the gas vent passageway; and backflow preventing means provided upstream of the receiver for allowing only a refrigerant flow running from the outdoor heat exchanger to the receiver, or auxiliary opening/closing means provided upstream of the receiver and being always opened during a normal operation, at least a path extending from the backflow preventing means or the auxiliary opening/closing means to the expansion valve via the receiver, and a path along the gas vent passageway extending from the receiver to the gas vent opening/closing means are provided on an outdoor side; and the refrigeration system further comprises control means which, before shutting down the compressor, opens the gas vent opening/closing means and closes the expansion valve while the compressor is left operating, and which closes the gas vent opening/closing means, or closes the gas vent opening/closing means and the auxiliary opening/closing means upon subsequent shut down of the compressor.
A standing intensive care unit nursing workstation, comprising a horizontally arranged main beam, and a monitoring column and a nursing column which are respectively connected to two ends of the main beam and extend to be fixed to a floor; the main beam is provided with a sleep lamp having a reflective device, a patient information digital display screen, an auxiliary illuminating lamp and an infusion solution pump support arm; the infusion solution pump support arm is provided with an alarm indicator, a medicine solution pump rack assembly and an examination illuminating lamp; the monitoring column is provided with a treatment monitoring function assembly; the nursing column is provided with a nursing function assembly; the monitoring column and the nursing column are respectively provided with a medical gas tube security control device and a power supply security control device; a rigid medical gas tube extends to the main beam, the monitoring column and the nursing column to correspondingly connect a medical gas tube security control device and a medical gas terminal; a strong/weak power supply extends to the main beam, the monitoring column and the nursing column to correspondingly connect a power supply security control device and a strong/weak power socket interface; characterized in that one end of the main beam extends in at least one direction different from a longitudinal direction of the main beam to form a horizontal segment, and the nursing column is connected to one end of the horizontal segment of the main beam, and a planar layout formed by the monitoring column, the nursing column, the infusion solution pump support arm and the main beam can change a position, a direction, a distance and an angle thereof according to a clinical need.
A locking mechanism comprising a clasp and a clasp receiver for engaging and locking with each other, said clasp receiver comprising: a body; a latch member biased in a first direction by a first biasing member, wherein a boundary between said latch member and said body defines a shear line and one of said latch member and said clasp having at least one protrusion for selectively engaging the other of said latch member and said clasp in locking engagement; a plurality of first pins biased in a second direction transverse to said first direction by respective second biasing members, wherein said plurality of first pins move between a locked condition, wherein said plurality of first pins straddle said shear line, and an unlocked condition, wherein said plurality of first pins do not straddle said shear line; and a plurality of combination dials at least partially contained in said body, said combination dials comprising a digit portion and a pin receiver portion, wherein each said combination dial has an unlocked rotational position in which one of said plurality of first pins engages a first recess in said pin receiver portion moving said one of said plurality of first pins to said unlocked condition. a body; a latch member biased in a first direction by a first biasing member, wherein a boundary between said latch member and said body defines a shear line and one of said latch member and said clasp having at least one protrusion for selectively engaging the other of said latch member and said clasp in locking engagement; a plurality of first pins biased in a second direction transverse to said first direction by respective second biasing members, wherein said plurality of first pins move between a locked condition, wherein said plurality of first pins straddle said shear line, and an unlocked condition, wherein said plurality of first pins do not straddle said shear line; and a plurality of combination dials at least partially contained in said body, said combination dials comprising a digit portion and a pin receiver portion, wherein each said combination dial has an unlocked rotational position in which one of said plurality of first pins engages a first recess in said pin receiver portion moving said one of said plurality of first pins to said unlocked condition.