An ophthalmic imaging device, comprising: A) an illumination module capable of generating a plurality of illumination modalities, wherein the illumination modalities include coherent illumination and incoherent illumination, and wherein the illumination module is configured to perform laser speckle contrast imaging; B) one or more imaging sensors configured to collect light from one or more regions of tissue of the back of the eye, said regions being the retina and/or the choroid; C) a primary optical assembly comprising one or more primary optical elements configured to direct light from the illumination module to the one or more regions of tissue of the back of the eye such that the light converges at the pupil or just in front of the pupil so that the light entering the eye is a divergent beam, and further configured to direct light from the one or more regions of tissue of the back of the eye to the one or more imaging sensors; or a first optical assembly comprising one or more first optical elements configured to direct light from the illumination module to one or more regions of tissue of the back of the eye such that the light converges at the pupil or just in front of the pupil so that the light entering the eye is a divergent beam and a second optical assembly comprising one or more second optical elements configured to direct light from the one or more regions of tissue of the back of the eye to the one or more imaging sensors; and D) one or more processors configured to calculate laser speckle contrast values for pixels of the one or more imaging sensors associated with the one or more regions of tissue of the back of the eye, wherein the calculated laser speckle contrast values use properties of a pixel's neighborhood of pixels in spatial or temporal domains; wherein the primary optical assembly, the first optical assembly, and/or the second optical assembly includes an aperture arranged to produce a speckle pattern on the one or more imaging sensors. A) an illumination module capable of generating a plurality of illumination modalities, wherein the illumination modalities include coherent illumination and incoherent illumination, and wherein the illumination module is configured to perform laser speckle contrast imaging; B) one or more imaging sensors configured to collect light from one or more regions of tissue of the back of the eye, said regions being the retina and/or the choroid; C) a primary optical assembly comprising one or more primary optical elements configured to direct light from the illumination module to the one or more regions of tissue of the back of the eye such that the light converges at the pupil or just in front of the pupil so that the light entering the eye is a divergent beam, and further configured to direct light from the one or more regions of tissue of the back of the eye to the one or more imaging sensors; or a first optical assembly comprising one or more first optical elements configured to direct light from the illumination module to one or more regions of tissue of the back of the eye such that the light converges at the pupil or just in front of the pupil so that the light entering the eye is a divergent beam and a second optical assembly comprising one or more second optical elements configured to direct light from the one or more regions of tissue of the back of the eye to the one or more imaging sensors; and D) one or more processors configured to calculate laser speckle contrast values for pixels of the one or more imaging sensors associated with the one or more regions of tissue of the back of the eye, wherein the calculated laser speckle contrast values use properties of a pixel's neighborhood of pixels in spatial or temporal domains; wherein the primary optical assembly, the first optical assembly, and/or the second optical assembly includes an aperture arranged to produce a speckle pattern on the one or more imaging sensors.