mhurhangee/ep-ind-claims huggingface dataset:
A method for predictably inserting a single nucleotide in a target region at a target site in DNA following Cas9-mediated cleavage, the method comprising: selecting a gene comprising the target region to be modified; designing a guide polynucleotide to target a selected 20 nt protospacer in the target region; producing a double-strand break at the target site in the target region using a Cas9 protein and the guide polynucleotide complementary to the protospacer in the target region such that the nucleotide at position 17 of the protospacer corresponds to an A or a T; wherein (i) for insertion of an A at the double-strand break at the target site, position 17 of the protospacer is A, or (ii) for insertion of a T at the double-strand break at the target site, position 17 of the protospacer is T; thus predictably inserting a single nucleotide at the target site following Cas9-mediated cleavage; wherein the method does not modify the germline genetic identity of a human being; wherein the method is not a method for treatment of the human or animal body by therapy. selecting a gene comprising the target region to be modified; designing a guide polynucleotide to target a selected 20 nt protospacer in the target region; producing a double-strand break at the target site in the target region using a Cas9 protein and the guide polynucleotide complementary to the protospacer in the target region such that the nucleotide at position 17 of the protospacer corresponds to an A or a T; wherein (i) for insertion of an A at the double-strand break at the target site, position 17 of the protospacer is A, or (ii) for insertion of a T at the double-strand break at the target site, position 17 of the protospacer is T; thus predictably inserting a single nucleotide at the target site following Cas9-mediated cleavage;
A heat-transfer device for facilitating heat exchange between a heat transfer object and a heat transfer medium flowing along a surface of the heat transfer object, the heat-transfer device comprising: at least one longitudinal vortex generating device that is a convex portion protruding from a surface side of the heat transfer object toward a flow passage of the heat transfer medium and inclined at an angle with respect to a flow direction of the heat transfer medium to generate a longitudinal vortex with a central axis in a flow direction of the heat transfer medium; and at least one radiator fin that is a plate-shaped member disposed in a standing condition on the surface of the heat transfer object in regions out of two regions A and B different in flow direction on a swirling plane of the longitudinal vortex, the region A being where a flow of the longitudinal vortex on the swirling plane is directed away from a heat transfer object side, the region B being where a flow of the longitudinal vortex on the swirling plane is directed toward the heat transfer object side, the at least one radiator fin extending in the flow direction of the heat transfer medium to exchange heat with the heat transfer medium stirred by the longitudinal vortex, the at least one radiator fin is provided on the surface of the heat transfer object only in region A, characterized in that an entirety of the at least one radiator fin is disposed only in an area downstream of the at least one longitudinal vortex generating device in the flow direction of the heat transfer medium. at least one longitudinal vortex generating device that is a convex portion protruding from a surface side of the heat transfer object toward a flow passage of the heat transfer medium and inclined at an angle with respect to a flow direction of the heat transfer medium to generate a longitudinal vortex with a central axis in a flow direction of the heat transfer medium; and at least one radiator fin that is a plate-shaped member disposed in a standing condition on the surface of the heat transfer object in regions out of two regions A and B different in flow direction on a swirling plane of the longitudinal vortex, the region A being where a flow of the longitudinal vortex on the swirling plane is directed away from a heat transfer object side, the region B being where a flow of the longitudinal vortex on the swirling plane is directed toward the heat transfer object side, the at least one radiator fin extending in the flow direction of the heat transfer medium to exchange heat with the heat transfer medium stirred by the longitudinal vortex, the at least one radiator fin is provided on the surface of the heat transfer object only in region A, characterized in that an entirety of the at least one radiator fin is disposed only in an area downstream of the at least one longitudinal vortex generating device in the flow direction of the heat transfer medium.
A laser surface treatment method for performing a surface treatment of a workpiece in order, with sectioning a surface of a workpiece having an irregular shape into a plurality of treating regions, the laser surface treatment comprising: defining a shape of each of the plurality of treating regions as a parallelogram in which a vertex on a bottom right in a a plane of paper forms an acute angle; in each surface treatment of the plurality of treating regions: radiating a laser so that the surface of the workpiece which is placed in a direction forming an acute angle with respect to the laser becomes an untreated plane; and scanning with the laser so that the surface of the workpiece which is placed in the direction forming an acute angle with respect to the laser becomes an untreated plane. radiating a laser so that the surface of the workpiece which is placed in a direction forming an acute angle with respect to the laser becomes an untreated plane; and scanning with the laser so that the surface of the workpiece which is placed in the direction forming an acute angle with respect to the laser becomes an untreated plane.
A process for preparing a derivatized cyclodextrin having a monomodal overall distribution profile, the process comprising: contacting the cyclodextrin starting material with an alkalinizing agent to form an alkaline mixture; providing the substituent precursor; contacting portions of the alkaline mixture with portions of the substituent precursor by continuously or semi-continuously flowing through a reactor to form a raw product comprising a cyclodextrin derivative. contacting the cyclodextrin starting material with an alkalinizing agent to form an alkaline mixture; providing the substituent precursor; contacting portions of the alkaline mixture with portions of the substituent precursor by continuously or semi-continuously flowing through a reactor to form a raw product comprising a cyclodextrin derivative.
A travel control device for a work vehicle, comprising: a hydraulic pump; a hydraulic motor for driving the front wheels and a hydraulic motor for driving the rear wheels with pressure oil delivered from the hydraulic pump, connected to the hydraulic pump in parallel through a closed-circuit connection; a slip detection device (30, 40, 42) that is configured to detect a slip occurring at any of the front wheels and the rear wheels; and characterized by a flow control device that is configured to quickly reduce, upon detection of the slip occurring at any of the front wheels and the rear wheels by the slip detection device (40, 42), a quantity of pressure oil supplied to a hydraulic motor for driving the wheel at which the slip has been detected, among the hydraulic motor for driving the front wheels and the hydraulic motor for driving the rear wheels, and to gradually restore the quantity of pressure oil supplied to the hydraulic motor (11, 21) to a value before reduction as the slip detection device (30, 40, 42) determines that the slip is eliminated after the quantity of pressure oil supplied to the hydraulic motor (11, 21) is reduced upon the detection of the slip by the slip detection device (30, 40, 42). a hydraulic pump; a hydraulic motor for driving the front wheels and a hydraulic motor for driving the rear wheels with pressure oil delivered from the hydraulic pump, connected to the hydraulic pump in parallel through a closed-circuit connection; a slip detection device (30, 40, 42) that is configured to detect a slip occurring at any of the front wheels and the rear wheels; and characterized by a flow control device that is configured to quickly reduce, upon detection of the slip occurring at any of the front wheels and the rear wheels by the slip detection device (40, 42), a quantity of pressure oil supplied to a hydraulic motor for driving the wheel at which the slip has been detected, among the hydraulic motor for driving the front wheels and the hydraulic motor for driving the rear wheels, and to gradually restore the quantity of pressure oil supplied to the hydraulic motor (11, 21) to a value before reduction as the slip detection device (30, 40, 42) determines that the slip is eliminated after the quantity of pressure oil supplied to the hydraulic motor (11, 21) is reduced upon the detection of the slip by the slip detection device (30, 40, 42).
A method of securing an optical fiber with a laser diode carrier in a position where the optical fiber is in optical coupling relationship with said laser diode, said carrier comprising an opening formed in a wall of said carrier for passing said fiber, characterised in that it comprises the following steps: - hermetic fastening of a ferule onto said optical fiber substantially at one end of said fiber, wherein said ferule exhibits a length greater than the thickness of said opening; - assembly of a first and of a second washers opposite said opening on both sides of said wall, wherein said first washer is installed in contact with said wall; - placing said ferule, so that said ferule protrudes from said washers on each side of said wall comprising a step of inserting said optical fiber in said first washer and in said opening; - aligning said optical fiber with said laser diode in a position optimising the optical coupling between said fiber and said diode and laser-welding of said washers with said ferule comprising a step of emitting a laser beam substantially tangent to the plane of the wall and substantially perpendicular to the axis of said fiber; - aligning said optical fiber with said laser diode in a position optimising optical coupling between said fiber and said diode and laser-welding of said washers with said wall comprising a step of emitting a laser beam substantially tangent to the plane of the wall and substantially perpendicular to the axis of said fiber. - hermetic fastening of a ferule onto said optical fiber substantially at one end of said fiber, wherein said ferule exhibits a length greater than the thickness of said opening; - assembly of a first and of a second washers opposite said opening on both sides of said wall, wherein said first washer is installed in contact with said wall; - placing said ferule, so that said ferule protrudes from said washers on each side of said wall comprising a step of inserting said optical fiber in said first washer and in said opening; - aligning said optical fiber with said laser diode in a position optimising the optical coupling between said fiber and said diode and laser-welding of said washers with said ferule comprising a step of emitting a laser beam substantially tangent to the plane of the wall and substantially perpendicular to the axis of said fiber; - aligning said optical fiber with said laser diode in a position optimising optical coupling between said fiber and said diode and laser-welding of said washers with said wall comprising a step of emitting a laser beam substantially tangent to the plane of the wall and substantially perpendicular to the axis of said fiber.
Sanitary fitting having a connecting thread, which has a receiving groove, which is provided with a knurling in its groove base and wherein the groove base is aligned parallel to the longitudinal centre line of the connecting thread and is delimited by two flanks, which are oriented orthogonally to the longitudinal centre line, wherein in the receiving groove a seal is arranged, characterised in that the thread of the connecting thread adjacent to the receiving groove on the side facing away from the free end of the connecting thread is reduced in height in relation to the other threads and that the seal has a base, on which a web is arranged, which is formed by steps arranged on both sides.
Use of a shrinkage reducing admixture in a concrete composition comprising, in a mixture with water, a hydraulic binder, sand and aggregates, wherein the hydraulic binder comprises a Portland cement of high reactivity, wherein the Portland cement has a Blaine fineness of 4500-6500 cm 2 /g, wherein the hydraulic binder is present in an amount of 280-310 kg per cubic meter of concrete, wherein the shrinkage reducing admixture is present in an amount of 3-4 L per cubic meter of concrete, wherein the shrinkage reducing admixture is an organic admixture, in particular based on polypropylene glycol, polyethylene glycol and/or a glycol ether derivative, preferably in a liquid mixture with surfactants, and wherein water is present in an amount of 140-160 1 per cubic meter of concrete, for reducing the drying time of the concrete composition.
A tricyclic phenolic compound of the general formula V in which the substituent R 1 is a hydrocarbyl radical which has from 1 to 3000 carbon atoms and may be interrupted by one or more heteroatoms from the group of O and S and/or by one or more NR 6 moieties, where R 6 is a hydrogen atom or a C 1 - to C 4 -alkyl radical, and in which the substituents R 2, R 3, R 4, R 5, R 8, R 9 and R 10 are each independently hydrogen atoms or hydrocarbyl radicals which have in each case from 1 to 3000 carbon atoms and may be interrupted by one or more heteroatoms from the group of O and S and/or by one or more NR 6 moieties, where R 6 is as defined above, with the proviso that at least one of the substituents R 1, R 2, R 3, R 4, R 5, R 8, R 9 and R 10 is a polyisobutenyl radical having a number-average molecular weight M n of from 183 to 42 000, and the remaining substituents from the group of R 1, R 2, R 3, R 4, R 5, R 8, R 9 and R 10, when they are hydrocarbyl radicals, each have from 1 to 20 carbon atoms. in which the substituent R 1 is a hydrocarbyl radical which has from 1 to 3000 carbon atoms and may be interrupted by one or more heteroatoms from the group of O and S and/or by one or more NR 6 moieties, where R 6 is a hydrogen atom or a C 1 - to C 4 -alkyl radical, and in which the substituents R 2, R 3, R 4, R 5, R 8, R 9 and R 10 are each independently hydrogen atoms or hydrocarbyl radicals which have in each case from 1 to 3000 carbon atoms and may be interrupted by one or more heteroatoms from the group of O and S and/or by one or more NR 6 moieties, where R 6 is as defined above, with the proviso that at least one of the substituents R 1, R 2, R 3, R 4, R 5, R 8, R 9 and R 10 is a polyisobutenyl radical having a number-average molecular weight M n of from 183 to 42 000, and the remaining substituents from the group of R 1, R 2, R 3, R 4, R 5, R 8, R 9 and R 10, when they are hydrocarbyl radicals, each have from 1 to 20 carbon atoms.
A display apparatus, comprising: a display panel configured to display an image by emitting light; at least one sound generating device (1600, 1600', 1600", 1800, 1800', 1800", 1900, 1900") on a rear surface of the display panel and configured to vibrate the display panel to generate sound; and a heat-dissipation member between the display panel and the sound generating device; wherein the at least one sound generating device (1600, 1600', 1600", 1800, 1800', 1800", 1900, 1900") includes: a coil; a bobbin, wherein one surface of the bobbin is in contact with the rear surface of the display panel and wherein the display panel is configured to be vibrated by a movement of the bobbin according to a current applied to the coil to generate the sound by the vibration of the display panel; and a protection member disposed on the bobbin between the heat-dissipation member and the bobbin and configured to cover and protect the bobbin. a display panel configured to display an image by emitting light; at least one sound generating device (1600, 1600', 1600", 1800, 1800', 1800", 1900, 1900") on a rear surface of the display panel and configured to vibrate the display panel to generate sound; and a heat-dissipation member between the display panel and the sound generating device; wherein the at least one sound generating device (1600, 1600', 1600", 1800, 1800', 1800", 1900, 1900") includes: a coil; a bobbin, wherein one surface of the bobbin is in contact with the rear surface of the display panel and wherein the display panel is configured to be vibrated by a movement of the bobbin according to a current applied to the coil to generate the sound by the vibration of the display panel; and a protection member disposed on the bobbin between the heat-dissipation member and the bobbin and configured to cover and protect the bobbin. a coil; a bobbin, wherein one surface of the bobbin is in contact with the rear surface of the display panel and wherein the display panel is configured to be vibrated by a movement of the bobbin according to a current applied to the coil to generate the sound by the vibration of the display panel; and a protection member disposed on the bobbin between the heat-dissipation member and the bobbin and configured to cover and protect the bobbin.
A luminescent rare earth compound, selected from the group comprising: Eu 0.6 Y 0.4 (Benzoic acid) 3, Eu 0.6 Y 0.4 (Isophthalic acid) 1.5, Eu 0.2 Y 0.8 (1,3,5-Benzene-tricarboxylic acid) 1, Tb 0.2 Y 0.8 (1,3,5-Benzene-tricarboxylic acid) 1, Eu 0.5 Y 0.5 (1,2,4,5-Benzene-tetracarboxylic acid) 0.75, Eu (Pyridine-4-carboxylic acid) 3, and /or Eu 0.6 Y 0.4 (2,5-Pyridinedicarboxylic acid) 1.5. Eu 0.6 Y 0.4 (Benzoic acid) 3, Eu 0.6 Y 0.4 (Isophthalic acid) 1.5, Eu 0.2 Y 0.8 (1,3,5-Benzene-tricarboxylic acid) 1, Tb 0.2 Y 0.8 (1,3,5-Benzene-tricarboxylic acid) 1, Eu 0.5 Y 0.5 (1,2,4,5-Benzene-tetracarboxylic acid) 0.75, Eu (Pyridine-4-carboxylic acid) 3, and /or Eu 0.6 Y 0.4 (2,5-Pyridinedicarboxylic acid) 1.5.
A method of aligning a workpiece between two exposure patterning operations, the method including: forming fiducials by a dry method in or on an exposure sensitive layer on a workpiece; measuring and recording first position information of the fiducials in a first coordinate system used by a writing system to apply a first exposure to the workpiece; physically moving the workpiece and repositioning it in the writing system; measuring and recording second position information of the fiducials or of a transfer from the fiducials onto another layer of the workpiece; using the second position information to align a second coordinate system relative to the first coordinate system; and applying a second exposure to the workpiece using the second coordinate system. forming fiducials by a dry method in or on an exposure sensitive layer on a workpiece; measuring and recording first position information of the fiducials in a first coordinate system used by a writing system to apply a first exposure to the workpiece; physically moving the workpiece and repositioning it in the writing system; measuring and recording second position information of the fiducials or of a transfer from the fiducials onto another layer of the workpiece; using the second position information to align a second coordinate system relative to the first coordinate system; and applying a second exposure to the workpiece using the second coordinate system.
A vacuum cleaning appliance comprising: a handheld vacuum cleaning device comprising a motor coupled to a fan for generating an air flow through a nozzle air inlet; and a support frame comprising: a cleaning head having a cleaning head air inlet; and an air outlet in fluid communication with the cleaning head air inlet, the air outlet configured to couple with the nozzle air inlet when the handheld vacuum cleaning device is secured to the support frame and to create an airflow path from the cleaning head air inlet to the nozzle air inlet; characterised in that the air outlet is moveable with respect to the support frame into a first position in which the air outlet projects from the support frame when the handheld vacuum cleaning device is detached from the support frame. a handheld vacuum cleaning device comprising a motor coupled to a fan for generating an air flow through a nozzle air inlet; and a support frame comprising: a cleaning head having a cleaning head air inlet; and an air outlet in fluid communication with the cleaning head air inlet, the air outlet configured to couple with the nozzle air inlet when the handheld vacuum cleaning device is secured to the support frame and to create an airflow path from the cleaning head air inlet to the nozzle air inlet; characterised in that the air outlet is moveable with respect to the support frame into a first position in which the air outlet projects from the support frame when the handheld vacuum cleaning device is detached from the support frame. a cleaning head having a cleaning head air inlet; and an air outlet in fluid communication with the cleaning head air inlet, the air outlet configured to couple with the nozzle air inlet when the handheld vacuum cleaning device is secured to the support frame and to create an airflow path from the cleaning head air inlet to the nozzle air inlet; characterised in that the air outlet is moveable with respect to the support frame into a first position in which the air outlet projects from the support frame when the handheld vacuum cleaning device is detached from the support frame.
A semiconductor device, comprising: a lead frame on which is mounted a semiconductor element; a first kind of mold resin that seals a mounting surface of the lead frame, which is a surface on which is mounted the semiconductor element; and a second kind of mold resin that seals a heat dissipating surface of the lead frame, which is a surface on a side opposite the mounting surface, wherein projections (7a, 8a, and 8d), in the following called frame form projections (7a, 8a, and 8d), molded from the first kind of mold resin and second kind of mold resin are provided on the outer peripheral end portions of the heat dissipating surface of the lead frame, two opposing frame form projections ( 8a, and 8d) and a thinly-molded portion covering a space between them are integrally molded from the second kind of mold resin, and two other opposing frame form projections are molded from the first kind of mold resin. a lead frame on which is mounted a semiconductor element; a first kind of mold resin that seals a mounting surface of the lead frame, which is a surface on which is mounted the semiconductor element; and a second kind of mold resin that seals a heat dissipating surface of the lead frame, which is a surface on a side opposite the mounting surface, wherein projections (7a, 8a, and 8d), in the following called frame form projections (7a, 8a, and 8d), molded from the first kind of mold resin and second kind of mold resin are provided on the outer peripheral end portions of the heat dissipating surface of the lead frame, two opposing frame form projections ( 8a, and 8d) and a thinly-molded portion covering a space between them are integrally molded from the second kind of mold resin, and two other opposing frame form projections are molded from the first kind of mold resin.
An active pharmaceutical ingredient selected from N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride, its stereoisomers and the acid addition salts thereof, for use in a method of treating glucocerebrosidase -associated Parkinson's disease or GBA-associated parkinsonism.