A multi-rotor aircraft with a multi-axis misalignment layout, comprising a frame, a plurality of upper power sources, and a plurality of lower power sources, wherein the multi-rotor aircraft further comprises: a plurality of upper propellers, which are provided at intervals and are connected above the frame through the plurality of upper power sources; and a plurality of lower propellers, which are provided at intervals and are connected below the frame through the plurality of lower power sources; wherein in the vertical projection direction of the frame, the plurality of upper propellers and the plurality of lower propellers are staggered, wherein the frame comprises: a frame center part; a plurality of connecting arms having a first end and a second end in an extending direction, wherein the first end of the plurality of connecting arms is connected to the frame center part, and the second end of the plurality of connecting arms is correspondingly connected with the plurality of upper propellers through the plurality of upper power sources or the plurality of lower propellers through the plurality of lower power sources; and at least one reinforcing arm, wherein an accommodating area is formed between the second ends of any two adjacent connecting arms, and at least one of the accommodating areas formed between the plurality of connecting arms is provided with the reinforcing arm; the upper propeller and the upper power source are connected to the top of the corresponding connecting arm, and the lower propeller and the lower power source are connected to the bottom of the corresponding connecting arm; and wherein in the vertical projection direction of the frame, the second ends of the plurality of connecting arms connected with the plurality of upper power sources and upper propellers are positioned higher than the second ends of the plurality of connecting arms connected with the plurality of lower power sources and lower propellers. a plurality of upper propellers, which are provided at intervals and are connected above the frame through the plurality of upper power sources; and a plurality of lower propellers, which are provided at intervals and are connected below the frame through the plurality of lower power sources; wherein in the vertical projection direction of the frame, the plurality of upper propellers and the plurality of lower propellers are staggered, wherein the frame comprises: a frame center part; a plurality of connecting arms having a first end and a second end in an extending direction, wherein the first end of the plurality of connecting arms is connected to the frame center part, and the second end of the plurality of connecting arms is correspondingly connected with the plurality of upper propellers through the plurality of upper power sources or the plurality of lower propellers through the plurality of lower power sources; and at least one reinforcing arm, wherein an accommodating area is formed between the second ends of any two adjacent connecting arms, and at least one of the accommodating areas formed between the plurality of connecting arms is provided with the reinforcing arm; the upper propeller and the upper power source are connected to the top of the corresponding connecting arm, and the lower propeller and the lower power source are connected to the bottom of the corresponding connecting arm; and wherein in the vertical projection direction of the frame, the second ends of the plurality of connecting arms connected with the plurality of upper power sources and upper propellers are positioned higher than the second ends of the plurality of connecting arms connected with the plurality of lower power sources and lower propellers. a frame center part; a plurality of connecting arms having a first end and a second end in an extending direction, wherein the first end of the plurality of connecting arms is connected to the frame center part, and the second end of the plurality of connecting arms is correspondingly connected with the plurality of upper propellers through the plurality of upper power sources or the plurality of lower propellers through the plurality of lower power sources; and at least one reinforcing arm, wherein an accommodating area is formed between the second ends of any two adjacent connecting arms, and at least one of the accommodating areas formed between the plurality of connecting arms is provided with the reinforcing arm; the upper propeller and the upper power source are connected to the top of the corresponding connecting arm, and the lower propeller and the lower power source are connected to the bottom of the corresponding connecting arm; and wherein in the vertical projection direction of the frame, the second ends of the plurality of connecting arms connected with the plurality of upper power sources and upper propellers are positioned higher than the second ends of the plurality of connecting arms connected with the plurality of lower power sources and lower propellers.