A magnetomotive system for increasing fluid flow through an obstructed blood vessel by wireless manipulation of magnetic nanoparticles, the system comprising: a base (202, 4702); an arm positioner (212, 512, 4712) coupled to the base; a permanent magnet coupled to the arm positioner, the permanent magnet producing a magnetic field and a directed magnetic gradient that is adapted to provide external magnetomotive control of magnetic nanoparticles introduced within vasculature of a subject, wherein the arm positioner is adapted to position and orient the permanent magnet relative to a head of a subject; a first slewing bearing configured to rotate the permanent magnet about a first axis of rotation; a second slewing bearing configured to rotate the permanent magnet about a second axis of rotation; a first controlled movement mechanism configured to rotate the first slewing bearing; a second controlled movement mechanism configured to rotate the second slewing bearing; a user interface adapted to display information and receive input from an operator for use in controlling operation of the magnetomotive system, wherein the input includes one or more of a target brain hemisphere, a target artery and a head orientation angle; a controller that is adapted to selectively actuate at least one of the first and second controlled movement mechanisms to manipulate at least one of a position and an orientation of the permanent magnet to create a rotating magnetic field and to control a direction and a magnitude of a magnetic gradient of the permanent magnet, wherein manipulation of at least one of the rotating magnetic field, the direction of the magnetic gradient, and the magnitude of the magnetic gradient causes magnetic nanoparticles present within the vasculature to agglomerate into a plurality of magnetic nanoparticle structures and causes the magnetic nanoparticle structures to travel through fluid within the vasculature in response to the rotating magnetic field and the magnetic gradient, and wherein the motion of travel increases exposure of a fluid obstruction within a blood vessel of the vasculature to a thrombolytic agent present in the blood vessel and accelerates action of the thrombolytic agent on the fluid obstruction. a base (202, 4702); an arm positioner (212, 512, 4712) coupled to the base; a permanent magnet coupled to the arm positioner, the permanent magnet producing a magnetic field and a directed magnetic gradient that is adapted to provide external magnetomotive control of magnetic nanoparticles introduced within vasculature of a subject, wherein the arm positioner is adapted to position and orient the permanent magnet relative to a head of a subject; a first slewing bearing configured to rotate the permanent magnet about a first axis of rotation; a second slewing bearing configured to rotate the permanent magnet about a second axis of rotation; a first controlled movement mechanism configured to rotate the first slewing bearing; a second controlled movement mechanism configured to rotate the second slewing bearing; a user interface adapted to display information and receive input from an operator for use in controlling operation of the magnetomotive system, wherein the input includes one or more of a target brain hemisphere, a target artery and a head orientation angle; a controller that is adapted to selectively actuate at least one of the first and second controlled movement mechanisms to manipulate at least one of a position and an orientation of the permanent magnet to create a rotating magnetic field and to control a direction and a magnitude of a magnetic gradient of the permanent magnet, wherein manipulation of at least one of the rotating magnetic field, the direction of the magnetic gradient, and the magnitude of the magnetic gradient causes magnetic nanoparticles present within the vasculature to agglomerate into a plurality of magnetic nanoparticle structures and causes the magnetic nanoparticle structures to travel through fluid within the vasculature in response to the rotating magnetic field and the magnetic gradient, and wherein the motion of travel increases exposure of a fluid obstruction within a blood vessel of the vasculature to a thrombolytic agent present in the blood vessel and accelerates action of the thrombolytic agent on the fluid obstruction.