A compound of formula, wherein R 1 is -L 1 -R 7, and wherein L 1 is a bond or a group selected from among methylene, ethylene, and ethenylene, and wherein R 7 is a ring selected from among cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyrrolidinyl, piperidinyl, azepanyl, tetrahydrofuranyl, tetrahydropyranyl, oxepanyl, phenyl, pyridyl, and furanyl, wherein L 1 if different from a bond is optionally substituted with one or more groups selected from among methyl, and ethyl, wherein the ring R 7 is optionally substituted with one or more groups selected from among -F, -Cl, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -t-butyl, -CF 3, -O-CF 3, -CN, -O-methyl, furanyl and phenyl, wherein said furanyl and said phenyl are optionally independently substituted by one or more groups selected from among -C 1 -C 3 -alkyl, halogen, -OCH 3, -CF 3, and -OCF 3, or wherein the ring R 7 is bi-valently substituted by one or more groups selected from among on two neighbouring ring atoms, such that an annellated ring is formed. wherein R 2 is selected from among -H, -halogen, -CN, -O-C 1 -C 4 -alkyl, -C 1 -C 4 -alkyl, -CH=CH 2, -C≡CH, -CF 3, -OCF 3, -OCF 2 H, and -OCFH 2; wherein R 3 is selected from among -H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -OCH 3, and -CN; wherein R 4 and R 5 are independently selected from among an electron pair, -H, and a group selected from among -C 1 -C 6 -alkyl, -NH 2, -C 3 -C 8 -cycloalkyl, -C 3 -C 8 -heterocyclyl, -C 5 -C 10 -aryl, -C 5 -C 10 -heteroaryl, and -C -N(R 8,R 8'), with R 8 and R 8' independently being selected from among -H, and -C 1 -C 6 -alkyl, and wherein R 4 and R 5 if different from an electron pair or -H are optionally independently substituted with one or more groups selected from among -halogen, -OH, -CF 3, -CN, -C 1 -C 6 -alkyl, -O-C 1 -C 6 -alkyl, -O-C 3 -C 8 -cycloalkyl, -O-C 3 -C 8 -heterocyclyl, -O-C 5 -C 10 -aryl, -O-C 5 -C 10 -heteroaryl, -C 0 -C 6 -alkylene-CN, -C 0 -C 4 -alkylene-O-C 1 -C 4 -alkyl, -C 0 -C 4 -alkylene-O-C 3 -C 8 -cycloalkyl, -C 0 -C 4 -alkylene-O-C 3 -C 8 -heterocyclyl, -C 0 -C 4 -alkylene-O-C 5 -C 10 -aryl, -C 0 -C 4 -alkylene-O-C 5 -C 10 -heteroaryl, -C 0 -C 4 -alkylene-Q-C 0 -C 4 -alkyl-N(R 9,R 9'), -C 0 -C 4 -alkylene-N(R 10)-Q-C 1 -C 4 -alkyl, -C 0 -C 4 -alkylene-N(R 10)-Q-C 3_ C 8 -cycloalkyl, -C 0 -C 4 -alkylene-N(R 10)-Q-C 3 -C 8 -heterocyclyl, -C 0 -C 4 -alkylene-N(R 10)-Q-C 5 -C 10 -aryl, -C 0 -C 4 -alkylene-N(R 10)-Q-C 5 -C 10 -heteroaryl, -C 0 -C 4 -alkylene-Q-N(R 11,R 11), -C 0 -C 4 -alkylen-N(R 12)-Q-N(R 13,R 13'), -C 0 -C 4 -alkylen-R 14, -C 0 -C 4 -alkylene-Q-C 1 -C 6 -alkyl, -C 0 -C 4 -alkylene-Q-C 3 -C 8 -cycloalkyl, -C 0 -C 4 -alkylene-Q-C 3 -C 8 -heterocyclyl, -C 0 -C 4 -alkylene-Q-C 5 -C 10 -aryl, -C 0 -C 4 -alkylene-Q-C 5 -C 10 -heteroaryl, -C 0 -C 4 -alkylene-O-Q-N(R 15,R 15'), and -C 0 -C 4 -alkylene-N(R 16)-Q-O-(R 17). wherein Q is selected from among -C -, and -SO 2 -, wherein R 12, R 16, are independently selected from among -H, -C 1 -C 6 -alkyl, and -C 3 -C 6 -cycloalkyl, wherein R 9, R 9 -, R 10, R 11, R 11, R 13, R 13', R 15, R 15', are independently selected from among -H, -C 1 -C 6 -alkyl, and -C 3 -C 6 -cycloalkyl, or wherein R 9 and R 9', R 11 and R 11', R 13 and R 13', R 15 and R 15' together form a -C 2 -C 6 -alkylene group, wherein R 14 and R 17 are independently selected from among -H, -C 1 -C 6 -alkyl, -C 5 -C 10 -aryl, -C 5 -C 10 -heteroaryl, -C 3 -C 8 -cycloalkyl, and -C 3 -C 8 -heterocyclyl, wherein said -C 3 -C 8 -heterocyclyl optionally comprises nitrogen and/or -SO 2 - in the ring, and wherein R 14 and R 17 are optionally substituted with one or more groups selected from among -OH, -OCH 3, -CF 3, -OCF 3, -CN, -halogen, -C 1 -C 4 -alkyl, =O, and -SO 2 -C 1 -C 4 -alkyl, or wherein R 4 and / or R 5 are independently a group of the structure -L 2 -R 18, wherein L 2 is selected from among -NH- and -N(C 1 -C 4 -alkyl)-, wherein R 18 is selected from among -C 5 -C 10 -aryl, -C 5 -C 10 -heteroaryl, -C 3 -C 8 -cycloalkyl, and -C 3 -C 8 -heterocyclyl, wherein R 18 is optionally substituted by one or more groups selected from among halogen, -CF 3, -OCF 3, -CN, -OH, -O-C 1 -C 4 -alkyl, -C 1 -C 6 -alkyl, -NH-C -C 1 -C 6 -alkyl, -N(C 1 -C 4 -alkyl)-C -C 1 -C 6 -alkyl, -C -C 1 -C 6 -alkyl, -S 2 -C 1 -C 6 -alkyl, -NH-S 2 -C 1 -C 6 -alkyl, -N(C 1 -C 4 -alkyl)-S 2 -C 1 -C 6 -alkyl, and -C -O-C 1 -C 6 -alkyl, and wherein R 4, R 5 and R 18 are optionally further substituted by spiro-C 3 -C 8 -cycloalkyl or spiro-C 3 -C 8 -heterocyclyl such that together with R 4, R 5 and/or R 18 a spirocycle is formed, wherein said spiro-C 3 -C 8 -heterocyclyl optionally comprises one or more groups selected from among nitrogen, -C -, -SO 2 -, and -N(SO 2 -C 1 -C 4 -alkyl)- in the ring, or wherein R 4, R 5 and R 18 are optionally further bi-valently substituted by one or more spirocyclic or annellated ring forming groups selected from among -C 1 -C 6 -alkylene, -C 2 -C 6 -alkenylene, and -C 4 -C 6 -alkynylene, in which one ore two carbon centers may optionally be replaced by one or two hetero atoms selected from among N, O and S and which may optionally be substituted by one or more groups on one ring atom or on two neighbouring ring atoms selected from among -OH, -NH 2, -C 1 -C 3 -alkyl, O-C 1 -C 6 -alkyl, -CN, -CF 3, -OCF 3, and halogen; wherein R 6 is selected from among -H, -C 1 -C 4 -alkyl, -OH, -O-C 1 -C 4 -alkyl, -halogen, -CN, -CF 3, and -OCF 3; wherein A is selected from among a single bond, -CH 2 -, -O-, -S-, and -NH-; wherein n is 1, 2 or 3; wherein Z is C or N, as well as in form of their acid addition salts with pharmacologically acceptable acids.