mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising nanoparticles comprising a taxane and a carrier protein for use in a method of treating a proliferative disease in a human, wherein the carrier protein is albumin, and wherein the method comprises intravenously administering the composition to the human in 10 minutes or less at a drug dosage of 5 to 300 mg/m 2.
A compound of Formula I, or an enantiomer, diastereoisomer, atropisomer, or a mixture thereof, or a pharmaceutically acceptable salt thereof, wherein: R 1 is -C 0-4 alk-O-C 1-8 alk, -C 0-4 alk-S-C 1-8 alk, or -C 0-4 alk-NH(C 1-8 alk); wherein said C 1-8 alk is substituted by 0, 1, 2, 3, 4, 5, or 6 halo; R 2 is H, halo, CN, C 1-6 alk, or C 1-6 haloalk; R 3 is C 1-6 alk, C 1-6 haloalk, -O-C 1-6 alk, -O-cyclopropyl, or -O-cyclobutyl; R 4 is a 5- to 6-membered heteroaryl; each of R 6 and R 7 is hydrogen; and each of R 5a; R 5b;R 5c; R 5d; and R 5e is independently hydrogen or halo. R 1 is -C 0-4 alk-O-C 1-8 alk, -C 0-4 alk-S-C 1-8 alk, or -C 0-4 alk-NH(C 1-8 alk); wherein said C 1-8 alk is substituted by 0, 1, 2, 3, 4, 5, or 6 halo; R 2 is H, halo, CN, C 1-6 alk, or C 1-6 haloalk; R 3 is C 1-6 alk, C 1-6 haloalk, -O-C 1-6 alk, -O-cyclopropyl, or -O-cyclobutyl; R 4 is a 5- to 6-membered heteroaryl; each of R 6 and R 7 is hydrogen; and each of R 5a; R 5b;R 5c; R 5d; and R 5e is independently hydrogen or halo.
A system for maintaining a serving dish at a desired temperature for serving food, comprising: a thermally conductive plate; at least one Peltier element in thermally conductive contact with the thermally conductive plate; and at least one fluid-to-air radiator in thermally conductive communication with the at least one Peltier element; characterized in that the thermally conductive plate may be heated by applying a current through the at least one Peltier element in a first direction and the thermally conductive plate may be cooled by applying a current through the at least one Peltier element in a second direction and removing heat from the at least one Peltier element using the at least one fluid-to-air radiator. a thermally conductive plate; at least one Peltier element in thermally conductive contact with the thermally conductive plate; and at least one fluid-to-air radiator in thermally conductive communication with the at least one Peltier element; characterized in that the thermally conductive plate may be heated by applying a current through the at least one Peltier element in a first direction and the thermally conductive plate may be cooled by applying a current through the at least one Peltier element in a second direction and removing heat from the at least one Peltier element using the at least one fluid-to-air radiator.
An assembly comprising a wheel and a non-pneumatic tire, the non-pneumatic tire comprising a plurality of helical springs, each helical spring comprising a first end portion, a second end portion, and an arching middle portion, wherein each helical spring is interlaced with at least one other helical spring thereby forming a laced toroidal structure extending about an entire circumference of the non-pneumatic tire, and wherein the first end portions of a plurality of helical springs are directly secured to a first annular structure of the wheel and the second end portions of the plurality of helical springs are directly secured to a second annular structure of the wheel, the first end portion of each of the plurality of helical springs being oriented coaxially with the second end portion of each of the plurality of helical springs, characterized in that the plurality of helical springs are constructed of 304ELC stainless steel, 10 Low-C stainless steel, 2024-T4 aluminum, 6061-T6 aluminum, 2219-T87 aluminum, 5052-H38 aluminum, 5083-H38 aluminum, nickel-based Monel, TD Nickel, nickel-based Hastlelloy B, nickel-based Inconel X, nickel-based Inconel 718, nickel-based Rene 41, 5Al-2.5Sn-Ti ELI titanium, Ti45A [AMS 4902] titanium or multiphase Co-35Ni-20Mo-10Cr alloy MP35N.
A method of indicating potential tampering with a security system component, the security system component including a camera lens, the method comprising: receiving an analytic alarm indicative of defocusing of the camera lens; receiving data from an accelerometer; receiving data from a light sensor; and using a computing device to analyze the analytic alarm indicative of defocusing of the camera lens, the data from the accelerometer and the data from the light sensor to determine whether tampering of the security system component has occurred, the analysis includes determining whether a predetermined acceleration threshold has been met at approximately a same time as: a change in lighting of a scene monitored by the camera lens; and the defocusing of the camera lens; and generating a qualified alarm signal when the analysis is indicative of tampering. receiving an analytic alarm indicative of defocusing of the camera lens; receiving data from an accelerometer; receiving data from a light sensor; and using a computing device to analyze the analytic alarm indicative of defocusing of the camera lens, the data from the accelerometer and the data from the light sensor to determine whether tampering of the security system component has occurred, the analysis includes determining whether a predetermined acceleration threshold has been met at approximately a same time as: a change in lighting of a scene monitored by the camera lens; and the defocusing of the camera lens; and a change in lighting of a scene monitored by the camera lens; and the defocusing of the camera lens; and generating a qualified alarm signal when the analysis is indicative of tampering.
A method performed by a residential control node (206, 600), arranged in a residential area, of enabling encrypted residential communication of user data between a first wireless communication device and a second wireless communication device, the method comprising: • receiving (3:3, 402) a radio bearer mapping from a communication network node (220, 700), arranged outside the residential area, • establishing (3:4, 404) a connection with the first wireless communication device, in accordance with the radio bearer mapping, • establishing (3:5, 406) a connection with the second wireless communication device, in accordance with the radio bearer mapping, • obtaining (3:7, 408) a first key which is based on a key of the first wireless communication device, from the communication network node (220, 700), • obtaining (3:7, 410) a second key which is based on a key of the second wireless communication device, such that the residential control node (206, 600) thereby is enabled to decrypt (3:10, 412) user data received (3:9) from the first wireless communication device by the first key, and encrypting (3:10, 414) the user data by the second key, before sending (3:11, 416) the user data to the second wireless communication device. • receiving (3:3, 402) a radio bearer mapping from a communication network node (220, 700), arranged outside the residential area, • establishing (3:4, 404) a connection with the first wireless communication device, in accordance with the radio bearer mapping, • establishing (3:5, 406) a connection with the second wireless communication device, in accordance with the radio bearer mapping, • obtaining (3:7, 408) a first key which is based on a key of the first wireless communication device, from the communication network node (220, 700), • obtaining (3:7, 410) a second key which is based on a key of the second wireless communication device,
A device for controlling travel of a vehicle, comprising: a processor configured to set a speed curve of the vehicle based on a relative speed and distance of the vehicle with respect to a front subject; and a controller configured to control the vehicle to travel according to the set speed curve" the processor is further configured to: establish an optimization function about speed based on the relative speed and distance of the vehicle with respect to the front subject; and solve the optimization function, such that the relative speed of the vehicle with respect to the front subject is close to zero when the vehicle travels at a speed corresponding to a solution obtained by solving the optimization function, characterized in that, the processor is further configured to: judge whether the optimization function has a solution when solving the optimization function, and if there is a solution, output an optimized curve about speed as the set speed curve; otherwise, instruct the controller to control the vehicle to travel at a first travel speed curve. a processor configured to set a speed curve of the vehicle based on a relative speed and distance of the vehicle with respect to a front subject; and a controller configured to control the vehicle to travel according to the set speed curve" the processor is further configured to: establish an optimization function about speed based on the relative speed and distance of the vehicle with respect to the front subject; and solve the optimization function, such that the relative speed of the vehicle with respect to the front subject is close to zero when the vehicle travels at a speed corresponding to a solution obtained by solving the optimization function, characterized in that, the processor is further configured to: judge whether the optimization function has a solution when solving the optimization function, and if there is a solution, output an optimized curve about speed as the set speed curve; otherwise, instruct the controller to control the vehicle to travel at a first travel speed curve. establish an optimization function about speed based on the relative speed and distance of the vehicle with respect to the front subject; and solve the optimization function, such that the relative speed of the vehicle with respect to the front subject is close to zero when the vehicle travels at a speed corresponding to a solution obtained by solving the optimization function, characterized in that, the processor is further configured to: judge whether the optimization function has a solution when solving the optimization function, and if there is a solution, output an optimized curve about speed as the set speed curve; otherwise, instruct the controller to control the vehicle to travel at a first travel speed curve.
Poppet valve having a valve body comprising a valve stem body, a valve head body with a valve combustion face and a valve fillet body interconnecting the valve stem body and the valve head body, wherein a thermal barrier coating is arranged on the valve fillet body to provide the valve fillet body surface with an increased thermal resistance compared to the valve combustion face; characterized in that the thermal barrier coating is a thermal sprayed coating of yttria-stabilized zirconia deposited on at least part of the valve fillet body surface using either atmospheric plasma spraying or high velocity oxygen fuel spraying (HVOF).
A wireless communication method, the method comprises processing a transmitted first data packet by using a first key through a first protocol stack; and processing a transmitted second data packet by using a second key through a second protocol stack, wherein the first protocol stack and the second protocol stack share at least one protocol layer, wherein the first key as well as the second key and the first protocol stack as well as the second protocol stack are concurrently used, and time for processing the first data packet by using the first key through the first protocol stack and time for processing the second data packet by using the second key through the second protocol stack at least partially overlap, wherein a data packet sender is a terminal device and a data packet receiver is one or more base stations; or the data packet sender is one or more base stations, and the data packet receiver is a terminal device, wherein the first key is a key before updating and the second key is an updated key, wherein the first key and the second key are used for performing encryption and/or integrity protection operations, or decryption and/or integrity verification on the data packets in a Packet Data Convergence Protocol, PDCP, layer, the first key and the second key being for different data packets respectively. processing a transmitted first data packet by using a first key through a first protocol stack; and processing a transmitted second data packet by using a second key through a second protocol stack, wherein the first protocol stack and the second protocol stack share at least one protocol layer, wherein the first key as well as the second key and the first protocol stack as well as the second protocol stack are concurrently used, and time for processing the first data packet by using the first key through the first protocol stack and time for processing the second data packet by using the second key through the second protocol stack at least partially overlap, wherein a data packet sender is a terminal device and a data packet receiver is one or more base stations; or the data packet sender is one or more base stations, and the data packet receiver is a terminal device, wherein the first key is a key before updating and the second key is an updated key, wherein the first key and the second key are used for performing encryption and/or integrity protection operations, or decryption and/or integrity verification on the data packets in a Packet Data Convergence Protocol, PDCP, layer, the first key and the second key being for different data packets respectively.
A drive assembly (1; 1') comprising: a first electrical machine a first connecting shaft rotated by torque applied by the first electrical machine; a second connecting shaft; a second electrical machine having a rotor assembly; and a drive shaft (2; 2') comprising: an inner shaft (4; 4') having: a first end connected to the first connecting shaft; and a second end connected to the second connecting shaft; and a hollow outer shaft (6; 6'), coaxial with the inner shaft (4; 4'), the outer shaft defining at least part of, or being operatively coupled to, the rotor assembly, and being releasably connected to the inner shaft (4; 4') so that the drive shaft (2; 2') is selectively configurable in a first arrangement for normal operating conditions where the outer shaft (6; 6') is connected to the inner shaft (4; 4') for rotation therewith, and a second arrangement where the outer shaft (6; 6') is not connected to the inner shaft (4; 4'). a first electrical machine a first connecting shaft rotated by torque applied by the first electrical machine; a second connecting shaft; a second electrical machine having a rotor assembly; and a drive shaft (2; 2') comprising: an inner shaft (4; 4') having: a first end connected to the first connecting shaft; and a second end connected to the second connecting shaft; and a hollow outer shaft (6; 6'), coaxial with the inner shaft (4; 4'), the outer shaft defining at least part of, or being operatively coupled to, the rotor assembly, and being releasably connected to the inner shaft (4; 4') so that the drive shaft (2; 2') is selectively configurable in a first arrangement for normal operating conditions where the outer shaft (6; 6') is connected to the inner shaft (4; 4') for rotation therewith, and a second arrangement where the outer shaft (6; 6') is not connected to the inner shaft (4; 4'). an inner shaft (4; 4') having: a first end connected to the first connecting shaft; and a second end connected to the second connecting shaft; and a first end connected to the first connecting shaft; and a second end connected to the second connecting shaft; and a hollow outer shaft (6; 6'), coaxial with the inner shaft (4; 4'), the outer shaft defining at least part of, or being operatively coupled to, the rotor assembly, and being releasably connected to the inner shaft (4; 4') so that the drive shaft (2; 2') is selectively configurable in a first arrangement for normal operating conditions where the outer shaft (6; 6') is connected to the inner shaft (4; 4') for rotation therewith, and a second arrangement where the outer shaft (6; 6') is not connected to the inner shaft (4; 4').
A method, comprising: (a) performing measurements of a time course variation of a dosage of at least one drug in a biological system to which the drug has been applied; (b) performing measurements of a time course variation of a therapeutic outcome of the biological system in response to the drug; (c) fitting results of the measurements of the dosage and the therapeutic outcome into a model of the therapeutic outcome; and (d) using the model of the therapeutic outcome, identifying an optimized dosage of the drug, wherein: the at least one drug is a combination of N drugs, with N being 2 or more; performing in (a) includes performing measurements of a time course variation of dosages of the N drugs in the biological system; performing in (b) includes performing measurements of a time course variation of a therapeutic outcome of the biological system in response to the N drugs; fitting in (c) includes fitting results of the measurements of the dosages and the therapeutic outcome into a model of the therapeutic outcome; and identifying in (d) includes, using the model of the therapeutic outcome, identifying an optimized combination of characteristics of the N drugs, wherein the model of the therapeutic outcome is a quadratic function of the dosages of the N drugs, wherein: the quadratic function includes m parameters, with m = 1 + 2N + ( N ( N - 1))/2, and fitting the results of the measurements includes deriving the m parameters; or the quadratic function includes m parameters, with m = 1 + 2 ( N - 1) + (( N - 1)( N - 2))/2, and fitting the results of the measurements includes deriving the m parameters. (a) performing measurements of a time course variation of a dosage of at least one drug in a biological system to which the drug has been applied; (b) performing measurements of a time course variation of a therapeutic outcome of the biological system in response to the drug; (c) fitting results of the measurements of the dosage and the therapeutic outcome into a model of the therapeutic outcome; and (d) using the model of the therapeutic outcome, identifying an optimized dosage of the drug, the at least one drug is a combination of N drugs, with N being 2 or more; performing in (a) includes performing measurements of a time course variation of dosages of the N drugs in the biological system; performing in (b) includes performing measurements of a time course variation of a therapeutic outcome of the biological system in response to the N drugs; fitting in (c) includes fitting results of the measurements of the dosages and the therapeutic outcome into a model of the therapeutic outcome; and identifying in (d) includes, using the model of the therapeutic outcome, identifying an optimized combination of characteristics of the N drugs, the quadratic function includes m parameters, with m = 1 + 2N + ( N ( N - 1))/2, and fitting the results of the measurements includes deriving the m parameters; or the quadratic function includes m parameters, with m = 1 + 2 ( N - 1) + (( N - 1)( N - 2))/2, and fitting the results of the measurements includes deriving the m parameters.
A natural or synthetic rubber curing or vulcanisation accelerator composition comprising a mixture or reaction mixture of a carbodithioic acid of formula or its internal salt and at least one activator which is an amine compound of formula H 2 N-X-NH 2 or H 2 N-Y-OH wherein R' and R" are independently selected from a C 2 -C 18 aliphatic moiety; aromatic moiety; alicyclic moiety; aromatic heterocyclic moiety; and aliphatic heterocyclic moiety or R' and R" may together form part of an aromatic heterocyclic ring moiety or aliphatic heterocyclic ring moiety; and X is selected from a C 2 -C 18 straight or branched, unsubstituted or substituted alkyl group; a straight or branched, unsubstituted or substituted C 2 -C 18 aminoalkyl group; a disulphide bond; a straight or branched, unsubstituted or substituted C 2 -C 18 hydroxyalkyl group, a straight or branched, unsubstituted or substituted C 2 -C 18 amino hydroxy alkyl group, a ring moiety; and Y is selected from C 2 -C 18 straight or branched, unsubstituted or substituted alkyl, hydroxyalkyl or aminoalkyl group wherein R' and R" are independently selected from a C 2 -C 18 aliphatic moiety; aromatic moiety; alicyclic moiety; aromatic heterocyclic moiety; and aliphatic heterocyclic moiety or R' and R" may together form part of an aromatic heterocyclic ring moiety or aliphatic heterocyclic ring moiety; and X is selected from a C 2 -C 18 straight or branched, unsubstituted or substituted alkyl group; a straight or branched, unsubstituted or substituted C 2 -C 18 aminoalkyl group; a disulphide bond; a straight or branched, unsubstituted or substituted C 2 -C 18 hydroxyalkyl group, a straight or branched, unsubstituted or substituted C 2 -C 18 amino hydroxy alkyl group, a ring moiety; and Y is selected from C 2 -C 18 straight or branched, unsubstituted or substituted alkyl, hydroxyalkyl or aminoalkyl group
Use of a native potato protein isolate as an improving agent for baked food products based on dough comprising a leavening agent, comprising preparing a dough which dough comprises a native potato protein isolate, said native potato protein isolate having a protein content of 90 % or more based on dry matter as determined from the weight of total Kjeldahl nitrogen multiplied by 6.25, wherein the native potato protein isolate is patatin, such that said use is to obtain a baked food product which is compact compared to a control product without added patatin.
Coolant pump for an internal combustion engine comprising a drive shaft, a coolant pump impeller arranged at least in a rotationally fixed manner on the drive shaft and via which coolant can be conveyed, an outer housing in which a delivery channel of the coolant pump is formed, an adjustable control slide, via which a flow cross-section of an annular gap between an outlet of the coolant pump impeller and the surrounding delivery channel can be controlled, characterized in that the control slide comprises an inner hollow cylindrical circumferential wall and an outer hollow cylindrical circumferential wall adapted to be displaced into the annular gap, which walls are connected to one another via a bottom and extend from the bottom towards the coolant pump impeller, the inner hollow cylindrical circumferential wall being mounted on a machined outer surface of a cylindrical section of a housing part of the coolant pump, and the outer hollow cylindrical circumferential wall is guided on a machined inner surface of an axially extending annular projection of a housing part of the coolant pump.