A method for screening for an antibody or antigen-binding fragment thereof binding to an antigenic protein, the method comprising: (i) preparing a cell overexpressing an antigenic protein, in which a biotinylated phospholipid is inserted into a membrane of the cell and the biotinylated phospholipid is bound to a streptavidin/magnetic-bead complex, (a) by treating a phospholipid/biotin/streptavidin/magnetic-bead complex, prepared by reacting a biotinylated phospholipid with streptavidin and magnetic beads, to a cell overexpressing an antigen protein, or (b) by treating a streptavidin/magnetic-bead complex to a cell in which a biotinylated phospholipid is inserted into the cell membrane prepared by culturing the cell in the presence of the biotinylated phospholipid; (ii) treating the cell with a library of antibodies or antigen-binding fragments thereof and selecting for antibodies or antigen-binding fragments thereof binding to the cell overexpressing the antigen protein using a magnetism-based system; (iii) reacting the selected antibodies or antigen-binding fragment thereof with a cell not expressing the antigen protein to select only for an antibody or antigen-binding fragment thereof specifically binding to the antigen protein; and (iv) separating and/or removing antibodies or antigen-binding fragments thereof binding to the cell not expressing the antigenic protein from the selected antibodies or antigen-binding fragments thereof, thereby obtaining the antibodies or antigen-binding fragments thereof binding to the antigenic protein. (i) preparing a cell overexpressing an antigenic protein, in which a biotinylated phospholipid is inserted into a membrane of the cell and the biotinylated phospholipid is bound to a streptavidin/magnetic-bead complex, (a) by treating a phospholipid/biotin/streptavidin/magnetic-bead complex, prepared by reacting a biotinylated phospholipid with streptavidin and magnetic beads, to a cell overexpressing an antigen protein, or (b) by treating a streptavidin/magnetic-bead complex to a cell in which a biotinylated phospholipid is inserted into the cell membrane prepared by culturing the cell in the presence of the biotinylated phospholipid; (a) by treating a phospholipid/biotin/streptavidin/magnetic-bead complex, prepared by reacting a biotinylated phospholipid with streptavidin and magnetic beads, to a cell overexpressing an antigen protein, or (b) by treating a streptavidin/magnetic-bead complex to a cell in which a biotinylated phospholipid is inserted into the cell membrane prepared by culturing the cell in the presence of the biotinylated phospholipid; (ii) treating the cell with a library of antibodies or antigen-binding fragments thereof and selecting for antibodies or antigen-binding fragments thereof binding to the cell overexpressing the antigen protein using a magnetism-based system; (iii) reacting the selected antibodies or antigen-binding fragment thereof with a cell not expressing the antigen protein to select only for an antibody or antigen-binding fragment thereof specifically binding to the antigen protein; and (iv) separating and/or removing antibodies or antigen-binding fragments thereof binding to the cell not expressing the antigenic protein from the selected antibodies or antigen-binding fragments thereof, thereby obtaining the antibodies or antigen-binding fragments thereof binding to the antigenic protein.