A surgical clip applier, comprising a housing; at least one handle pivotably connected to the housing; a channel assembly extending distally from the housing; a clip carrier disposed within said channel assembly and defining a channel and a plurality of windows therein; a plurality of clips slidably disposed within said channel of said clip carrier; a wedge plate reciprocally disposed within said channel assembly, said wedge plate being operatively connected to said at least one handle and including a plurality of apertures formed along a length thereof; a clip follower slidably disposed within said channel of said clip carrier and disposed proximally of said plurality of clips, said clip follower being configured and adapted for selective engagement with said windows of said clip carrier and said apertures of said wedge plate, wherein said clip follower is configured and adapted to urge said plurality of clips, in a distal direction relative to said clip carrier, upon reciprocal movement of said wedge plate, a jaw assembly including a pair of jaws extending from an end of said channel assembly, opposite said housing, said jaw assembly adapted to accommodate a clip therein and being operable to effect formation of a clip in response to movement of said at least one handle, a drive channel translatably slidably disposed within at least one of said housing and said channel assembly, said drive channel having a first end operatively connected to said at least one handle and a second end configured and dimensioned to selectively engage said pair of jaws to effectuate closure of said pair of jaws, wherein said drive channel is moved towards said jaw assembly as said at least one handle is moved to move said second end thereof against said jaws to close said jaws, wherein said drive channel is moved towards said jaw assembly as said at least one handle is moved in a first direction, and said drive channel is moved away from said jaws as said at least one handle is moved a second amount to move said second end thereof away from said jaws to allow said jaws to open, a clip pusher bar reciprocally positioned within at least one of said housing and said channel assembly, said pusher bar having a first end operatively connected to said at least one handle and a second end defining a pusher, said pusher bar being movable towards said jaws as said at least one handle is approximated in a first direction by an initial amount in order to move a distal-most clip between said jaws, and said pusher bar being configured and adapted to move towards said housing as said at least one handle is approximated an additional amount in said first direction to move said pusher behind a distal-most clip in said plurality of clips, and a lockout disposed in a distal end of said channel assembly; characterized in that the drive channel is configured and dimensioned to at least partially surround said jaws and said wedge plate, said drive channel including a strap extending across a distal end thereof for maintaining said jaws and said wedge plate within said drive channel, and the lockout is actuated by said clip follower when a last clip is expelled from said clip applier; wherein said lockout is urged by said clip follower to extend across a path of said strap of said drive channel, thereby preventing said drive channel from moving distally.