mhurhangee/ep-ind-claims huggingface dataset:
A bifunctional fusion protein or antigen-binding portion thereof comprising at least one of polypeptide chain, wherein the polypeptide chain comprises: a binding domain binding to a cell surface protein, wherein the binding domain binds programmed cell death protein 1 ligand (PD-L1), and the binding domain comprises: a heavy chain variable domain and a light chain variable region respectively comprising an amino acid sequence selected from the group consisting of: SEQ ID NO. 4 and amino acid 1-111 of SEQ ID NO. 3; and SEQ ID NO. 6 and amino acid 1-110 of SEQ ID NO. 5; and a vascular endothelial growth factor (VEGF) inhibiting domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs. 1, 2, 9, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, and a combination thereof. a binding domain binding to a cell surface protein, wherein the binding domain binds programmed cell death protein 1 ligand (PD-L1), and the binding domain comprises: a heavy chain variable domain and a light chain variable region respectively comprising an amino acid sequence selected from the group consisting of: SEQ ID NO. 4 and amino acid 1-111 of SEQ ID NO. 3; and SEQ ID NO. 6 and amino acid 1-110 of SEQ ID NO. 5; and SEQ ID NO. 4 and amino acid 1-111 of SEQ ID NO. 3; and SEQ ID NO. 6 and amino acid 1-110 of SEQ ID NO. 5; and a vascular endothelial growth factor (VEGF) inhibiting domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs. 1, 2, 9, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, and a combination thereof.
An axle assembly (10, 10b, 10c, 10d) comprising: an input member (86, 86b, 1314); a first planetary gear set (40, 40b) having a first transmission input (54, 54b, 54d) that is driven by the input member (86, 86b, 1314); a differential assembly (36, 36d) having a differential carrier and first and second differential output members (100, 102) received in the differential carrier; a second planetary gear set (42, 42b) having a planet carrier (76, 76b, 76d), which is coupled to the differential carrier for common rotation, and a ring gear; and a housing (58, 1340) into which the first planetary gearset (40, 40b) and the second planetary gearset (42, 42b) are received; wherein a sun gear of the first planetary gear set (40, 40b) is non-rotatably coupled to a sun gear of the second planetary gear set (42, 42b); and wherein the ring gear of the second planetary gearset (42, 42b) is fixedly coupled to the housing (58, 1340). an input member (86, 86b, 1314); a first planetary gear set (40, 40b) having a first transmission input (54, 54b, 54d) that is driven by the input member (86, 86b, 1314); a differential assembly (36, 36d) having a differential carrier and first and second differential output members (100, 102) received in the differential carrier; a second planetary gear set (42, 42b) having a planet carrier (76, 76b, 76d), which is coupled to the differential carrier for common rotation, and a ring gear; and a housing (58, 1340) into which the first planetary gearset (40, 40b) and the second planetary gearset (42, 42b) are received; wherein a sun gear of the first planetary gear set (40, 40b) is non-rotatably coupled to a sun gear of the second planetary gear set (42, 42b); and wherein the ring gear of the second planetary gearset (42, 42b) is fixedly coupled to the housing (58, 1340).
A heat exchanger comprising a heat exchange tube and a first water collecting tank, the first water collecting tank being provided on the heat exchange tube, a first water diversion hole being provided at a bottom portion of the first water collecting tank, the heat exchange tube passing through the first water diversion hole, and the first water diversion hole having a diameter greater than an outer diameter of the heat exchange tube; further comprising an upper side plate, wherein the upper side plate is located above the first water collecting tank, a mounting hole is provided on the upper side plate, and the heat exchange tube is fixedly mounted in the mounting hole; wherein a drainage structure is further provided on the upper side plate, and water flows through the drainage structure into the first water collecting tank; characterized in that the drainage structure has a plurality of drainage holes; wherein the drainage holes are provided on the upper side plate at intervals, and one drainage hole is provided between every two adjacent mounting holes. further comprising an upper side plate, wherein the upper side plate is located above the first water collecting tank, a mounting hole is provided on the upper side plate, and the heat exchange tube is fixedly mounted in the mounting hole; wherein a drainage structure is further provided on the upper side plate, and water flows through the drainage structure into the first water collecting tank; characterized in that the drainage structure has a plurality of drainage holes; wherein the drainage holes are provided on the upper side plate at intervals, and one drainage hole is provided between every two adjacent mounting holes.
A polypeptide dimer comprising two monomers, each monomer having at least 90% sequence identity to SEQ ID NO: 1, wherein the monomers comprise the gp130 D6 domain corresponding to the amino acids at positions 585-595 of SEQ ID NO:1, an Fc domain hinge region comprising the amino acids at positions 609-612 of SEQ ID NO:1, and the monomers do not comprise a linker between the gp130 portion and the Fc domain, for use in the treatment of an inflammatory disease or an IL-6-mediated condition in a human, wherein the polypeptide dimer is administered in a dose of 60 mg to 1 g.
A method of conforming an overwrap to a pessary device, the method comprising: a. providing a pessary device comprising a longitudinal axis, a transverse axis, and an outer surface: b. providing an overwrap; c. placing the pessary device in contact with an overwrap comprising anchoring at least one of the ends of the overwrap, wherein the overwrap enrobes the pessary device outer surface area to form a hollow structure; characterized in that the method further comprises d. manipulating the overwrap to conform to the pessary device comprising rotating the hollow structure in contact with the pessary device along the longitudinal axis. a. providing a pessary device comprising a longitudinal axis, a transverse axis, and an outer surface: b. providing an overwrap; c. placing the pessary device in contact with an overwrap comprising anchoring at least one of the ends of the overwrap, wherein the overwrap enrobes the pessary device outer surface area to form a hollow structure; characterized in that the method further comprises d. manipulating the overwrap to conform to the pessary device comprising rotating the hollow structure in contact with the pessary device along the longitudinal axis.
A method for detecting mechanical defects of a semiconductor device, in particular a solar cell or solar cell arrangement, having at least one pn-junction in a semiconductor layer formed of a semiconductor material with an indirect band junction, wherein - a voltage is applied to the at least one pn-junction for operating the pn-junction in a transmitting direction, - the radiation behavior of the semiconductor layer generated by the applied voltage is optically detected and analyzed at least for partial regions of the semiconductor layer, characterized in that the integral over the radiation intensity of at least a first partial region (44, 42) of a first semiconductor layer is automatically determined, subsequently the integral over the radiation intensity of at least one comparison region of the same semiconductor layer (44, 42) or of a second semiconductor layer (42, 40) is determined, and on the basis of the result of an automatic comparison of the two integrals, the first partial region is characterized as defective or as defect-free. - a voltage is applied to the at least one pn-junction for operating the pn-junction in a transmitting direction, - the radiation behavior of the semiconductor layer generated by the applied voltage is optically detected and analyzed at least for partial regions of the semiconductor layer, characterized in that the integral over the radiation intensity of at least a first partial region (44, 42) of a first semiconductor layer is automatically determined, subsequently the integral over the radiation intensity of at least one comparison region of the same semiconductor layer (44, 42) or of a second semiconductor layer (42, 40) is determined, and on the basis of the result of an automatic comparison of the two integrals, the first partial region is characterized as defective or as defect-free.
A socket assembly comprising: - one or more spring probes; - a leadframe assembly including one or more cantilever members, the leadframe assembly having impedance controlled microwave structures and a flexible ground plane; - an elastomeric spacer adjacent the leadframe assembly and supporting the cantilever members, characterized in further comprising: - a housing having the one or more spring probes therein, - the leadframe assembly disposed within the housing, and - the elastomeric spacer receiving the spring probes therethrough. - one or more spring probes; - a leadframe assembly including one or more cantilever members, the leadframe assembly having impedance controlled microwave structures and a flexible ground plane; - an elastomeric spacer adjacent the leadframe assembly and supporting the cantilever members, characterized in further comprising: - a housing having the one or more spring probes therein, - the leadframe assembly disposed within the housing, and - the elastomeric spacer receiving the spring probes therethrough.
A method for removing a mold release agent from an adherend region where an adherend is to be affixed to a side surface of a tire after a cure-molding process, the method comprising: moving along and intermittently irradiating a laser light having an intensity capable of removing rubber on the side surface of the tire in the adherend region such that a plurality of dents are formed in the adherend region with adjoining dents having edges overlapped with each other.
Method for decomposing an oxide layer containing chromium, iron, nickel, and optionally zinc and radionuclides using an aqueous oxidative decontamination solution containing permanganic acid and a mineral acid, flowing in a circuit, wherein the oxidative decontamination solution is adjusted to a pH ≤ 2.5, especially for decomposing oxide layers deposited on the interior surfaces of areas or components of a nuclear power plant, wherein the oxidation of the oxide layer and its dissolution takes place in a single treatment step with the aid of the aqueous decontamination solution, that sulfuric acid is used as the mineral acid for adjusting the pH, and that after degradation of the permanganic acid, while maintaining the flow in the circuit, the solution flows over a bypass line of the circuit to a cation exchanger in which divalent cations and divalent radionuclides present in the solution are fixed with simultaneous liberation of sulfate and dichromate anions.
A single-screw extrusion desulfurization and post-processing system, wherein the system comprises: a single-screw desulfurization device; the single-screw desulfurization device includes a desulfurizing feeding unit and a desulfurizing unit which are connected with each other, and a desulfurizing screw running through the desulfurizing feeding unit and the desulfurizing unit; a heating structure is respectively disposed in the desulfurizing unit and the desulfurizing screw; characterized in that: a heating structure is also disposed in the desulfurizing feeding unit, and in that the system further comprises: a single-screw post-processing device and a closed connection device for connecting the single-screw desulfurization device and the single-screw post-processing device; the single-screw post-processing device includes a post-processing feeding unit and a post-processing unit which are connected with each other, and a post-processing screw running through the post-processing feeding unit and the post-processing unit.
A process of producing a soy protein product having a soy protein content of at least 60 wt% (N x 6.25) on a dry weight basis, which comprises: (a) extracting a soy protein source which is soy meal, soy flakes, soy grits or soy flour with an aqueous calcium salt solution at a pH of 1.5 to 5 to cause solubilization of soy protein from the soy protein source and to form an aqueous soy protein solution, (b) separating the aqueous soy protein solution from residual soy protein source, and (c) diluting said aqueous soy protein solution with 0.5 to 10 volumes of water to a conductivity of less than 90 mS, (d) adjusting the pH of the aqueous solution to a different value within the range of 1.5 to 5 to a pH of 2.0 to 4.0, (e) concentrating the pH adjusted soy protein solution while maintaining the ionic strength thereof substantially constant to produce a concentrated soy protein solution having a protein concentration of 50 to 300 g/L, and the concentrated soy protein solution is optionally diafiltered, and (f) drying the concentrated and optionally diafiltered soy protein solution to provide a soy protein product having a protein content of at least 60 wt%. (a) extracting a soy protein source which is soy meal, soy flakes, soy grits or soy flour with an aqueous calcium salt solution at a pH of 1.5 to 5 to cause solubilization of soy protein from the soy protein source and to form an aqueous soy protein solution, (b) separating the aqueous soy protein solution from residual soy protein source, and (c) diluting said aqueous soy protein solution with 0.5 to 10 volumes of water to a conductivity of less than 90 mS, (d) adjusting the pH of the aqueous solution to a different value within the range of 1.5 to 5 to a pH of 2.0 to 4.0, (e) concentrating the pH adjusted soy protein solution while maintaining the ionic strength thereof substantially constant to produce a concentrated soy protein solution having a protein concentration of 50 to 300 g/L, and the concentrated soy protein solution is optionally diafiltered, and (f) drying the concentrated and optionally diafiltered soy protein solution to provide a soy protein product having a protein content of at least 60 wt%.
A composition comprising a halogenated volatile compound and hydroxypropyl cellulose for topical administration, wherein said halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixture thereof.
An electrochemical reactor for electrochemically treating water, comprising a shell structure defining an inner space, said shell structure further comprising: - an inlet portion comprising an inlet for conducting a water flow to the inner space; - a reactor chamber in flow connection with the inlet portion, and with an outlet portion, the reactor chamber being arranged for receiving plate portions of electrode plates so as to direct the water flow past the said electrode plates, wherein electrode plates are arranged as a plurality of electrode modules within the reactor chamber, wherein the inlet is arranged such that the water flow to the inner space is directed away from the reactor chamber so as to cause the water flow to mix by forcing the water flow to change direction before entering the reactor chamber, wherein the inlet portion is arranged below the reactor chamber, and wherein the inlet portion comprises a deflection surface, opposite to the flow connection between the inlet portion and the reactor chamber, the inlet being arranged such that the water flow to the inner space is directed towards the deflection surface, away from the electrode plates 7 in the reactor chamber, characterized in that the deflection surface is a curved surface, concave towards the inlet, and is provided as an inner surface the shell structure, when in use, at a bottom of the inlet portion, wherein the inlet is positioned at a distance of between 50 - 500mm, from the deflection surface, and at a distance of between 50 - 500mm from the electrode plates, and wherein the inlet is equipped with one or both of - a bent portion facing away from the reactor chamber for directing the water flow away from the reactor chamber, or - one or more openings facing away from the reactor chamber for directing the water flow away from the reactor chamber. - an inlet portion comprising an inlet for conducting a water flow to the inner space; - a reactor chamber in flow connection with the inlet portion, and with an outlet portion, the reactor chamber being arranged for receiving plate portions of electrode plates so as to direct the water flow past the said electrode plates, - a bent portion facing away from the reactor chamber for directing the water flow away from the reactor chamber, or - one or more openings facing away from the reactor chamber for directing the water flow away from the reactor chamber.
Process for the manufacture of an amino ester of formula R 1 -O-C -(CH 2) n -NH 2 in which n is an integer from 10 to 15 from an unsaturated ester responding to formula R 1 -O-C -(CH 2) m -CH=CH-R 2 in which - R 1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; - R 2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and - m is equal to 7, 8, 9, 10 or 11; said process comprising • submitting the unsaturated ester of formula to a catalytic cross-metathesis reaction with a pentenenitrile chosen among 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula R 1 -O-C -(CH 2) m -CH=CH-(CH 2) p -CN in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and • submitting the obtained ester-nitrile of formula to an hydrogenation in order to obtain the amino ester of formula. - R 1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; - R 2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and - m is equal to 7, 8, 9, 10 or 11; • submitting the unsaturated ester of formula to a catalytic cross-metathesis reaction with a pentenenitrile chosen among 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula R 1 -O-C -(CH 2) m -CH=CH-(CH 2) p -CN in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and • submitting the obtained ester-nitrile of formula to an hydrogenation in order to obtain the amino ester of formula.
A fuse switch module comprising: an electrically insulating casing having an aperture providing access to the casing interior, a pair of fixed contacts (5,6) placed inside the casing, a rotatable fuse cartridge made of an electrically insulating material and placed inside the casing, wherein the fuse cartridge is adapted for receiving a fuse, so that when a fuse is received in the fuse cartridge, the fuse and the fuse cartridge are jointly rotatable, and wherein the fuse cartridge is rotatable between a switch module closed position in which a fuse would be connected with the fixed contacts (5,6) to enable current circulation through a fuse and the fixed contacts (5,6) when a fuse is received in the fuse cartridge, and a switch module open position in which current circulation through the fixed contacts (5,6) is impeded, characterized in that the fuse switch module further comprises a cover installed at the aperture in movable manner for opening and closing the aperture, and wherein the cover and the fuse cartridge comprise locking means to engage with each other when the cover is closing the aperture and when the fuse cartridge is in the switch closed position, the cover is locked by the fuse cartridge and opening of the cover is impeded. an electrically insulating casing having an aperture providing access to the casing interior, a pair of fixed contacts (5,6) placed inside the casing, a rotatable fuse cartridge made of an electrically insulating material and placed inside the casing, wherein the fuse cartridge is adapted for receiving a fuse, so that when a fuse is received in the fuse cartridge, the fuse and the fuse cartridge are jointly rotatable, and wherein the fuse cartridge is rotatable between a switch module closed position in which a fuse would be connected with the fixed contacts (5,6) to enable current circulation through a fuse and the fixed contacts (5,6) when a fuse is received in the fuse cartridge, and a switch module open position in which current circulation through the fixed contacts (5,6) is impeded, characterized in that the fuse switch module further comprises a cover installed at the aperture in movable manner for opening and closing the aperture, and wherein the cover and the fuse cartridge comprise locking means to engage with each other when the cover is closing the aperture and when the fuse cartridge is in the switch closed position, the cover is locked by the fuse cartridge and opening of the cover is impeded.
An artificial vascular layer comprising: a substrate defining a network of channels having at least one input channel and at least one output channel and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, length, a width, and a diameter, wherein the intermediate channels are formed in accordance with Murray's law by varying said height and width with respect to adjacent portions of the input and output channels and the length of at least one of the channels is formed based on the respective diameter whereby said channels have a biomimetic length, preferably a scaled biomimetic length. a substrate defining a network of channels having at least one input channel and at least one output channel and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, length, a width, and a diameter, wherein the intermediate channels are formed in accordance with Murray's law by varying said height and width with respect to adjacent portions of the input and output channels and the length of at least one of the channels is formed based on the respective diameter whereby said channels have a biomimetic length, preferably a scaled biomimetic length.