A compound which is represented by Formula: or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein: X 3 and X 4 are each independently CR 6 or N; Y 2, Y 3a, Y 4, and Y 5 are each independently selected from C, CR 4a, N, NR 4b, S, or O; with the proviso that at least one of Y 2, Y 3a, Y 4, and Y 5 is N or NR 4b; and the dashed circle denotes optional bonds forming an aromatic ring; R 1 is CO 2 H; R 2a is hydrogen, chloro, fluoro, or C 1-4 alkyl; R 3 is halo, cyano, hydroxyl, amino, oxo, -OR a, -SR a, =S, -NR c R c, =NH, =N-OH, =NR a, =N-OR a, -NO 2, -S 2 R a, -S 2 NHR b, -S 2 NR c R c, -S 2 OR b, -OS 2 R b, -OS 2 OR b, -P (OR b)(OR b), -C R b, -C(NR b)R b, -C OR b, -C NR c R c, -C(NR b)NR c R c, -OC R b, -NR b C R b, -OC OR b, -NR b C OR b, -OC NR c R c, -NR b C NR c R c, -NR b C(NR b)R b, -NR b C(NR b)NR c R c, C 1-6 alkyl, C 1-6 deuterated alkyl, C 1-6 heteroalkyl, 6- to 10-membered aryl, arylalkyl, 5- to 10-membered heteroaryl, heteroarylalkyl, 3- to 8-membered carbocyclyl, carbocyclylalkyl, 4- to 8-membered heterocyclyl, or heterocyclylalkyl; wherein the alkyl, heteroalkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, and R a, by themselves or as part of another group, are each independently substituted with 0 to 5 R d; R a is selected from C 1-6 alkyl, C 1-6 deuterated alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl; R b is each independently hydrogen or R a; R c is each independently R b; or alternatively, two R c, taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclyl; R d is each independently selected from R a, alkoxy, haloalkoxy, alkylamino, cycloalkylamino, heterocyclylamino, haloalkyl, hydroxyalkyl, aminoalkyl, cycloalkoxy, heterocyclyloxy, haloalkoxy, alkoxyalkoxy, haloalkylamino, alkoxyalkylamino, haloalkoxyalkylamino, arylamino, aralkylamino, aryloxy, aralkyloxy, heteroaryloxy, heteroarylalkyloxy, alkylthio, halo, cyano, hydroxyl, amino, oxo, -OR a, -SR a, =S, -NR c R c, =NH, =N-OH, =NR a, =N-OR a, -NO 2, -S 2 R a, -S 2 NHR b, -S 2 NR c R c, -S 2 OR b, -OS 2 R b, -OS 2 OR b, -P (OR b)(OR b), -C R b, -C(NR b)R b, -C OR b, -C NR c R c, -C(NR b)NR c R c, -OC R b, -NR b C R b, -OC OR b, -NR b C OR b, -NR b C NR c R c, -NR b C(NR b)R b, and -NR b C(NR b)NR c R c; or alternatively one or two R d on alkyl, heteroalkyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl, taken together with the atoms to which the R d is attached, form a cyclic or bridge moiety; R 4a is each independently hydrogen, halo, C 1-4 alkyl, C 1-4 haloalkyl, C 2-6 alkoxyalkyl, or C 1-4 alkoxy; R 4b is each independently hydrogen or C 1-4 alkyl; and R 6 is hydrogen, halo, cyano, hydroxyl, amino, C 1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy. X 3 and X 4 are each independently CR 6 or N; Y 2, Y 3a, Y 4, and Y 5 are each independently selected from C, CR 4a, N, NR 4b, S, or O; with the proviso that at least one of Y 2, Y 3a, Y 4, and Y 5 is N or NR 4b; and the dashed circle denotes optional bonds forming an aromatic ring; R 1 is CO 2 H; R 2a is hydrogen, chloro, fluoro, or C 1-4 alkyl; R 3 is halo, cyano, hydroxyl, amino, oxo, -OR a, -SR a, =S, -NR c R c, =NH, =N-OH, =NR a, =N-OR a, -NO 2, -S 2 R a, -S 2 NHR b, -S 2 NR c R c, -S 2 OR b, -OS 2 R b, -OS 2 OR b, -P (OR b)(OR b), -C R b, -C(NR b)R b, -C OR b, -C NR c R c, -C(NR b)NR c R c, -OC R b, -NR b C R b, -OC OR b, -NR b C OR b, -OC NR c R c, -NR b C NR c R c, -NR b C(NR b)R b, -NR b C(NR b)NR c R c, C 1-6 alkyl, C 1-6 deuterated alkyl, C 1-6 heteroalkyl, 6- to 10-membered aryl, arylalkyl, 5- to 10-membered heteroaryl, heteroarylalkyl, 3- to 8-membered carbocyclyl, carbocyclylalkyl, 4- to 8-membered heterocyclyl, or heterocyclylalkyl; wherein the alkyl, heteroalkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, and R a, by themselves or as part of another group, are each independently substituted with 0 to 5 R d; R a is selected from C 1-6 alkyl, C 1-6 deuterated alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, and heterocyclylalkyl; R b is each independently hydrogen or R a; R c is each independently R b; or alternatively, two R c, taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclyl; R d is each independently selected from R a, alkoxy, haloalkoxy, alkylamino, cycloalkylamino, heterocyclylamino, haloalkyl, hydroxyalkyl, aminoalkyl, cycloalkoxy, heterocyclyloxy, haloalkoxy, alkoxyalkoxy, haloalkylamino, alkoxyalkylamino, haloalkoxyalkylamino, arylamino, aralkylamino, aryloxy, aralkyloxy, heteroaryloxy, heteroarylalkyloxy, alkylthio, halo, cyano, hydroxyl, amino, oxo, -OR a, -SR a, =S, -NR c R c, =NH, =N-OH, =NR a, =N-OR a, -NO 2, -S 2 R a, -S 2 NHR b, -S 2 NR c R c, -S 2 OR b, -OS 2 R b, -OS 2 OR b, -P (OR b)(OR b), -C R b, -C(NR b)R b, -C OR b, -C NR c R c, -C(NR b)NR c R c, -OC R b, -NR b C R b, -OC OR b, -NR b C OR b, -NR b C NR c R c, -NR b C(NR b)R b, and -NR b C(NR b)NR c R c; or alternatively one or two R d on alkyl, heteroalkyl, aryl, heteroaryl, carbocyclyl, or heterocyclyl, taken together with the atoms to which the R d is attached, form a cyclic or bridge moiety; R 4a is each independently hydrogen, halo, C 1-4 alkyl, C 1-4 haloalkyl, C 2-6 alkoxyalkyl, or C 1-4 alkoxy; R 4b is each independently hydrogen or C 1-4 alkyl; and R 6 is hydrogen, halo, cyano, hydroxyl, amino,