mhurhangee/ep-ind-claims huggingface dataset:
A crystalline form of the succinate salt of -6-((1-acetylpiperidin-4-yl)amino)- N- (3-(3,4-dihydroisoquinolin-2(1 H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide characterized by an X-ray powder diffraction (XRPD) pattern comprising at least three diffraction angles, when measured using Cu K α radiation, selected from a group consisting of: (i) about 4.5, 8.2, 9.0, 10.4, 13.5, 15.8, 16.4, 17.3, 17.7, 18.1, 18.8, 19.6, 20.8, 21.9, 22.7, 23.3, 24.0, 24.7, 26.4, 28.2, and 29.6 degrees 2θ; (ii) about 4.5, 8.2, 10.4, 13.5, 15.8, 16.4, 17.3, 17.7, 18.1, 18.8, 19.6, 20.8, 21.9, 23.3, and 24.0 degrees 2θ; or (iii) about 4.5, 8.2, 10.4, 13.5, 15.8, 16.4, 17.7, 18.1, 18.8, 20.8, 21.9, 23.3, and 24.0 degrees 2θ. (i) about 4.5, 8.2, 9.0, 10.4, 13.5, 15.8, 16.4, 17.3, 17.7, 18.1, 18.8, 19.6, 20.8, 21.9, 22.7, 23.3, 24.0, 24.7, 26.4, 28.2, and 29.6 degrees 2θ; (ii) about 4.5, 8.2, 10.4, 13.5, 15.8, 16.4, 17.3, 17.7, 18.1, 18.8, 19.6, 20.8, 21.9, 23.3, and 24.0 degrees 2θ; or (iii) about 4.5, 8.2, 10.4, 13.5, 15.8, 16.4, 17.7, 18.1, 18.8, 20.8, 21.9, 23.3, and 24.0 degrees 2θ.
A glass article having a thickness t, the glass article comprising a compressive layer extending from a surface of the glass article to a depth of compression DOC, wherein stress in the glass article varies as a function of the thickness t to form a stress profile, the stress profile comprising: a first region extending from the surface to a depth d1 into the glass, wherein d1 ≤ 0.025t and wherein the first region has a maximum compressive stress CS1 at the surface, wherein the maximum compressive stress CS1 is at least 280 MPa; a second region extending from a depth of at least d1 to a second depth d2, wherein d2 ≤ 0.0625t, wherein the second region has a compressive stress maximum CS2 and wherein the stress profile increases from a compressive stress at the depth d1 to the compressive stress maximum CS2 and decreases from the compressive stress maximum CS2 to a second compressive stress at second depth d2; and a third region extending from a third depth d3 in the glass article to the depth of compression DOC, wherein d2 ≤ d3 and wherein 0.15 t ≤ DOC ≤ 0.25t. a first region extending from the surface to a depth d1 into the glass, wherein d1 ≤ 0.025t and wherein the first region has a maximum compressive stress CS1 at the surface, wherein the maximum compressive stress CS1 is at least 280 MPa; a second region extending from a depth of at least d1 to a second depth d2, wherein d2 ≤ 0.0625t, wherein the second region has a compressive stress maximum CS2 and wherein the stress profile increases from a compressive stress at the depth d1 to the compressive stress maximum CS2 and decreases from the compressive stress maximum CS2 to a second compressive stress at second depth d2; and a third region extending from a third depth d3 in the glass article to the depth of compression DOC, wherein d2 ≤ d3 and wherein 0.15 t ≤ DOC ≤ 0.25t.
A method of manufacturing an electrosurgical seal plate, comprising: forming the seal plate; photolithographically etching one or more recesses or pockets on a seal surface of the seal plate; positioning a spacer into the one or more recesses or pockets, and depositing an adhesive into the one or more recesses or pockets. forming the seal plate; photolithographically etching one or more recesses or pockets on a seal surface of the seal plate; positioning a spacer into the one or more recesses or pockets, and depositing an adhesive into the one or more recesses or pockets.
An endoluminal prosthesis comprising a tubular main graft body, the tubular main graft body comprising: a sidewall, a proximal end, and a distal end; a first stent positioned near the proximal end of the main graft body, and a second stent positioned adjacent to and distal of the first stent, each of the first stent and the second stent comprising a peak and a valley; an opening in the sidewall positioned longitudinally between the peak of the first stent and the valley of the second stent; and a tubular branch comprising a first portion extending inward from the side wall, a second portion extending outward from the side wall, and an intermediate portion attached to the side wall about a circumference of the tubular branch, the branch having a first end opening and a second end opening, the branch being flexibly orientable between a retrograde configuration and an antegrade configuration, wherein, in the retrograde configuration, the first end opening is oriented toward the distal end of the main graft body and the second end opening is oriented toward the proximal end of the main graft body, and, in the antegrade configuration, the first end opening is oriented toward the proximal end of the main graft body and the second end opening is oriented toward the distal end of the main graft body, characterised in that the opening in the side wall comprises a slit extending at least partially circumferentially around the main graft body and in that the portion of the graft body adjacent to the slit deforms a portion of the branch. a sidewall, a proximal end, and a distal end; a first stent positioned near the proximal end of the main graft body, and a second stent positioned adjacent to and distal of the first stent, each of the first stent and the second stent comprising a peak and a valley; an opening in the sidewall positioned longitudinally between the peak of the first stent and the valley of the second stent; and a tubular branch comprising a first portion extending inward from the side wall, a second portion extending outward from the side wall, and an intermediate portion attached to the side wall about a circumference of the tubular branch, the branch having a first end opening and a second end opening, the branch being flexibly orientable between a retrograde configuration and an antegrade configuration, wherein, in the retrograde configuration, the first end opening is oriented toward the distal end of the main graft body and the second end opening is oriented toward the proximal end of the main graft body, and, in the antegrade configuration, the first end opening is oriented toward the proximal end of the main graft body and the second end opening is oriented toward the distal end of the main graft body, characterised in that the opening in the side wall comprises a slit extending at least partially circumferentially around the main graft body and in that the portion of the graft body adjacent to the slit deforms a portion of the branch.
A differential de-embed probe, comprising: two inputs configured to connect to a device under test; a memory; a signal generator configured to output a differential signal, including a first and a second signal; a plurality of load components, each load component configured to provide a different load; a plurality of switches, a first and second switch of the plurality of switches associated with the signal generator and the other switches of the plurality of switches each associated with one load component, the first and second switch each configured to connect at least one of the first signal and the second signal to one of the two inputs; and a controller configured to control the plurality of switches to connect combinations of the loads from the plurality of load components and the signal from the signal generator across the two inputs. two inputs configured to connect to a device under test; a memory; a signal generator configured to output a differential signal, including a first and a second signal; a plurality of load components, each load component configured to provide a different load; a plurality of switches, a first and second switch of the plurality of switches associated with the signal generator and the other switches of the plurality of switches each associated with one load component, the first and second switch each configured to connect at least one of the first signal and the second signal to one of the two inputs; and a controller configured to control the plurality of switches to connect combinations of the loads from the plurality of load components and the signal from the signal generator across the two inputs.
A peptide having the amino acid sequence: [Y n ···Y 1]ZX 1 X 2 X 3 S(p)[W 1 ···W m] wherein, m equals 2; and n is an integer from 3 to 7, such that said polypeptide consists of 10 to 13 amino acid residues, and wherein the peptide is sequenced based on a GSK-3 substrate, includes a phosphorylated serine or threonine residue, includes an amino acid residue other than serine or threonine at the fourth position upstream of said phosphorylated serine or threonine, and includes, downstream of the phosphorylated serine or threonine, an aromatic amino acid residue, such that: S(p) is said phosphorylated serine residue or a phosphorylated threonine residue; Z is any amino acid residue excepting serine residue or threonine residue; X 1 -X 3 and Y 1 -Yn are each independently any amino acid residue, sequenced based on said GSK-3 substrate; W 1 is any amino acid residue; and W 2 is said aromatic amino acid residue, wherein said GSK-3 substrate is selected from HSF-1, pIRS-1, p9CREB, and pGS-1. m equals 2; and n is an integer from 3 to 7, such that said polypeptide consists of 10 to 13 amino acid residues, and wherein the peptide is sequenced based on a GSK-3 substrate, includes a phosphorylated serine or threonine residue, includes an amino acid residue other than serine or threonine at the fourth position upstream of said phosphorylated serine or threonine, and includes, downstream of the phosphorylated serine or threonine, an aromatic amino acid residue, such that: S(p) is said phosphorylated serine residue or a phosphorylated threonine residue; Z is any amino acid residue excepting serine residue or threonine residue; X 1 -X 3 and Y 1 -Yn are each independently any amino acid residue, sequenced based on said GSK-3 substrate; W 1 is any amino acid residue; and W 2 is said aromatic amino acid residue, wherein said GSK-3 substrate is selected from HSF-1, pIRS-1, p9CREB, and pGS-1. S(p) is said phosphorylated serine residue or a phosphorylated threonine residue; Z is any amino acid residue excepting serine residue or threonine residue; X 1 -X 3 and Y 1 -Yn are each independently any amino acid residue, sequenced based on said GSK-3 substrate; W 1 is any amino acid residue; and W 2 is said aromatic amino acid residue,
A pharmaceutical composition comprising midodrine or a pharmaceutically acceptable salt thereof as an active ingredient, for use in treating or preventing diabetic cataract.
Surgical instrument, in particular for tissue separation, comprising a grip region which has a first grip part that is fixed in a position of use, and a second grip part which is movable in an adjustment direction relative to the first grip part, wherein, on the second grip part, at least two articulation points (5, 17) are formed which are offset relative to each other and by which the adjustment direction of the second grip part relative to the first grip part is defined, wherein the adjustment direction of the second grip part is determined by at least two guide elements (10, 11), wherein each guide element (10, 11) is connected to the first grip part via a respective articulation point and connected to the second grip part via a respective articulation point, wherein the articulation points on the first grip part are arranged offset to each other, and wherein the articulation points on the second grip part are arranged offset to each other, characterized in that the surgical instrument has a drive element which is connected to the first grip part via a bearing point (5, 16, 17) and connected to the second grip part via a bearing point (5, 16, 17).
An aircraft gas turbine engine comprising: a main shaft; a towershaft operatively coupled to the main shaft and operable to rotate about a first axis; a multi-axis accessory gearbox comprising: a gearbox housing disposed about the towershaft; a drive shaft skewed to the main shaft and operable to rotate about a second axis that intersects the first axis at a first angle; a bevel pinion gear mounted on the towershaft; a drive shaft bevel gear mounted on the drive shaft; and a side bevel gear set operable to directly drive at least one side accessory device, the side bevel gear set comprising an input gear meshing with one or more side bevel gears, each side bevel gear being independently positionable relative to the input gear and each having a side bevel gear axis at a second angle to the first axis, the second angle being the same between each side bevel gear axis and the first axis and independent of any other angle, wherein the input gear is mounted on the drive shaft and comprises the drive shaft bevel gear or at least one drive shaft bevel pinion gear; or the input gear is mounted on the towershaft and comprises the bevel pinion gear. a main shaft; a towershaft operatively coupled to the main shaft and operable to rotate about a first axis; a multi-axis accessory gearbox comprising: a gearbox housing disposed about the towershaft; a drive shaft skewed to the main shaft and operable to rotate about a second axis that intersects the first axis at a first angle; a bevel pinion gear mounted on the towershaft; a drive shaft bevel gear mounted on the drive shaft; and a side bevel gear set operable to directly drive at least one side accessory device, the side bevel gear set comprising an input gear meshing with one or more side bevel gears, each side bevel gear being independently positionable relative to the input gear and each having a side bevel gear axis at a second angle to the first axis, the second angle being the same between each side bevel gear axis and the first axis and independent of any other angle, a gearbox housing disposed about the towershaft; a drive shaft skewed to the main shaft and operable to rotate about a second axis that intersects the first axis at a first angle; a bevel pinion gear mounted on the towershaft; a drive shaft bevel gear mounted on the drive shaft; and a side bevel gear set operable to directly drive at least one side accessory device, the side bevel gear set comprising an input gear meshing with one or more side bevel gears, each side bevel gear being independently positionable relative to the input gear and each having a side bevel gear axis at a second angle to the first axis, the second angle being the same between each side bevel gear axis and the first axis and independent of any other angle,
A printing apparatus comprising: a printing unit configured to perform printing on a printing medium; a drive unit configured to cause the printing unit to move; a power supply unit configured to supply power to the drive unit; a detection unit configured to detect the movement of the printing unit; and a controller configured to control an initialization operation related to the printing unit based on a detection result of the detection unit, characterized in that, when power supply from the power supply unit to the drive unit is started, the controller is configured to acquire the detection result obtained when power is not supplied, said detection result being based on an electromotive force generated in said drive unit, perform the initialization operation in a case where movement of the printing unit is detected in the detection result, and not perform the initialization operation in a case where movement of the printing unit is not detected in the detection result. a printing unit configured to perform printing on a printing medium; a drive unit configured to cause the printing unit to move; a power supply unit configured to supply power to the drive unit; a detection unit configured to detect the movement of the printing unit; and a controller configured to control an initialization operation related to the printing unit based on a detection result of the detection unit, characterized in that, when power supply from the power supply unit to the drive unit is started, the controller is configured to acquire the detection result obtained when power is not supplied, said detection result being based on an electromotive force generated in said drive unit, perform the initialization operation in a case where movement of the printing unit is detected in the detection result, and not perform the initialization operation in a case where movement of the printing unit is not detected in the detection result.
A memory system, comprising: a memory configured to operate in a self-refresh mode and an auto-refresh mode, the memory having a plurality of memory locations; and a memory controller configured to access a first one of the memory locations while a second one of the memory locations is being refreshed in the auto-refresh mode, wherein the memory comprises a plurality of memory banks, the first one of the memory locations being located in a first one of the memory banks and the second one of the memory locations being located in a second one of the memory banks, wherein the memory further comprises a refresh address register configured to sequence through a plurality of memory addresses in the self-refresh mode, each of the memory addresses corresponding to one of the memory locations to be refreshed in the self-refreshed mode, and wherein the memory controller has access to the refresh address register, wherein the memory further comprises a readable register coupled to the refresh address register, the memory controller having read access to the refresh address register through the readable register, characterized in that the memory controller is provided read access to the address in the refresh address register by loading the address into the readable register in the memory, and reading the address from the readable register into the memory controller, wherein the readable register comprises a mode register. a memory configured to operate in a self-refresh mode and an auto-refresh mode, the memory having a plurality of memory locations; and a memory controller configured to access a first one of the memory locations while a second one of the memory locations is being refreshed in the auto-refresh mode, wherein the memory comprises a plurality of memory banks, the first one of the memory locations being located in a first one of the memory banks and the second one of the memory locations being located in a second one of the memory banks, wherein the memory further comprises a refresh address register configured to sequence through a plurality of memory addresses in the self-refresh mode, each of the memory addresses corresponding to one of the memory locations to be refreshed in the self-refreshed mode, and wherein the memory controller has access to the refresh address register, wherein the memory further comprises a readable register coupled to the refresh address register, the memory controller having read access to the refresh address register through the readable register, characterized in that the memory controller is provided read access to the address in the refresh address register by loading the address into the readable register in the memory, and reading the address from the readable register into the memory controller, wherein the readable register comprises a mode register.
A method of forming a GaN layer on a silicon substrate, the method comprising: growing, in a metal organic chemical vapor deposition tool, an AlN film on a crystalline Al 2 O 3 film that is on a <111> -oriented top surface of a silicon wafer, wherein growing the AlN film comprises annealing to remove contamination from a surface of the Al 2 O 3 film at about 850° C to 950° C for 5 to 20 minutes, wherein during the annealing an amorphous film of AlSiO is formed between the silicon wafer and the Al 2 O 3 film on the top surface of the silicon wafer and voids are formed in the Al 2 O 3 film; and depositing a plurality of laminate layers over the Al 2 O 3 film, wherein each laminate layer includes a layer of GaN (402, 504, 508, 512) over a layer of AlN (308, 502, 506, 510), wherein the first laminate layer closest to the top surface of the silicon substrate fills in the voids and regions in the GaN film in the first laminate layer over a void in the Al 2 O 3 film have a particularly high threading dislocation density. growing, in a metal organic chemical vapor deposition tool, an AlN film on a crystalline Al 2 O 3 film that is on a <111> -oriented top surface of a silicon wafer, wherein growing the AlN film comprises annealing to remove contamination from a surface of the Al 2 O 3 film at about 850° C to 950° C for 5 to 20 minutes, wherein during the annealing an amorphous film of AlSiO is formed between the silicon wafer and the Al 2 O 3 film on the top surface of the silicon wafer and voids are formed in the Al 2 O 3 film; and an amorphous film of AlSiO is formed between the silicon wafer and the Al 2 O 3 film on the top surface of the silicon wafer and voids are formed in the Al 2 O 3 film; and depositing a plurality of laminate layers over the Al 2 O 3 film, wherein each laminate layer includes a layer of GaN (402, 504, 508, 512) over a layer of AlN (308, 502, 506, 510), wherein the first laminate layer closest to the top surface of the silicon substrate fills in the voids and regions in the GaN film in the first laminate layer over a void in the Al 2 O 3 film have a particularly high threading dislocation density.
An IL-6 aptamer comprising a sequence selected from: (a) a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, 11, 19 to 22, 26 to 39, 100, 102 to 239, 400 to 446, and 599 to 625; or (b) a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, and 400, wherein 1 to 5 nucleotide are substituted, deleted, or inserted; wherein the IL-6 aptamer specifically binds IL-6 with an affinity (K d) of less than 20 nM; or (c) a nucleotide sequence that is at least 95% or more, identical to a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, and 400; wherein the IL-6 aptamer specifically binds IL-6 with an affinity (K d) of less than 20 nM. (a) a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, 11, 19 to 22, 26 to 39, 100, 102 to 239, 400 to 446, and 599 to 625; or (b) a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, and 400, wherein 1 to 5 nucleotide are substituted, deleted, or inserted; wherein the IL-6 aptamer specifically binds IL-6 with an affinity (K d) of less than 20 nM; or (c) a nucleotide sequence that is at least 95% or more, identical to a nucleotide sequence selected from SEQ ID NOs: 101, 7, 8, and 400; wherein the IL-6 aptamer specifically binds IL-6 with an affinity (K d) of less than 20 nM.
Compressor blade of a gas-turbine engine with a flow-exposed leading edge to which over at least part of the length of the leading edge a component, made of wear-resistant material and featuring a higher erosive wear resistance than the base material, is attached, wherein the component forming the flow-exposed leading edge is of a ridge-type design, features an essentially rectangular cross-section and, with reference to a sectional plane perpendicular to the radial direction, is arranged only on the inflow side of the compressor blade profile in a partial area of the sectional surface of the inflow area, characterized in that the component is embedded in the blade profile.