A computer-implemented method for determining one or more regions for tissue dissection in a series of pathology slides using a series of images which represent a digitized version of the series of pathology slides, the method comprising: - obtaining a first annotation identifying a first region for tissue dissection in a first image of the series of images; - obtaining a second annotation identifying a second region for tissue dissection in a second image of the series of images, wherein the first image and the second image are separated in the series of images by a series of intermediate images; and - generating an annotation (251, 252) for one or more intermediate images from the series of intermediate images by, for each one of said one or more images: - determining a first set of registration parameters representing an at least partial registration of the intermediate image with the first image; - determining a second set of registration parameters representing an at least partial registration of the intermediate image with the second image; - propagating the first annotation from the first image to the intermediate image using the first set of registration parameters; - propagating the second annotation from the second image to the intermediate image using the second set of registration parameters; and - combining said propagated first annotation and second annotation to obtain the annotation in the intermediate image. - obtaining a first annotation identifying a first region for tissue dissection in a first image of the series of images; - obtaining a second annotation identifying a second region for tissue dissection in a second image of the series of images, wherein the first image and the second image are separated in the series of images by a series of intermediate images; and - generating an annotation (251, 252) for one or more intermediate images from the series of intermediate images by, for each one of said one or more images: - determining a first set of registration parameters representing an at least partial registration of the intermediate image with the first image; - determining a second set of registration parameters representing an at least partial registration of the intermediate image with the second image; - propagating the first annotation from the first image to the intermediate image using the first set of registration parameters; - propagating the second annotation from the second image to the intermediate image using the second set of registration parameters; and - combining said propagated first annotation and second annotation to obtain the annotation in the intermediate image. - determining a first set of registration parameters representing an at least partial registration of the intermediate image with the first image; - determining a second set of registration parameters representing an at least partial registration of the intermediate image with the second image; - propagating the first annotation from the first image to the intermediate image using the first set of registration parameters; - propagating the second annotation from the second image to the intermediate image using the second set of registration parameters; and - combining said propagated first annotation and second annotation to obtain the annotation in the intermediate image.