mhurhangee/ep-ind-claims huggingface dataset:
Process for the preparation of a modified antibody, the process comprising attaching a monosaccharide derivative Su x to a proximal N-linked GlcNAc-residue, in the presence of a catalyst selected from the group consisting of β (1,4)-galactosyltransferases, β (1,3)-N-galactosyltransferases, β (1,4)-galactosyltransferases comprising a mutant catalytic domain and β (1,3)-N-galactosyltransferases comprising a mutant catalytic domain; wherein Su x is defined as a monosaccharide derivative Su comprising x functional groups A wherein x is 1, 2, 3 or 4 and wherein A is selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group or a precursor thereof, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group, wherein a precursor of a thiol group is -[C(R 7) 2] o SC CH 3, wherein R 7 is independently selected from the group consisting of hydrogen, halogen and an optionally substituted C 1 - C 24 alkyl group, and o is 0 - 24; wherein said proximal N-linked GlcNAc-residue is attached to the N-linked glycosylation site of an IgG antibody comprising one N-linked glycosylation site on the combination of a single heavy chain and single light chain, wherein said N-linked glycosylation site is a mutant N-linked glycosylation site as compared to its wild type counterpart, and wherein the proximal N-linked GlcNAc-residue is according to Formula: wherein b is 0 or 1.
A medical device comprising: a core assembly enclosing integrated circuitry, the core assembly comprising a first end and a second end; a header coupled to the first end of the core assembly, the header comprising a first end coupled to the first end of the core assembly, and a second end; an antenna arranged within the header and configured to communicate data; an electrode arranged within the header and configured to collect data; and a scaffold assembly configured to position and support the electrode relative to the antenna; characterized in that a distance between a position of at least a portion of the antenna and the second end of the header is shorter than a distance between a position of the electrode and the second end of the header. a core assembly enclosing integrated circuitry, the core assembly comprising a first end and a second end; a header coupled to the first end of the core assembly, the header comprising a first end coupled to the first end of the core assembly, and a second end; an antenna arranged within the header and configured to communicate data; an electrode arranged within the header and configured to collect data; and a scaffold assembly configured to position and support the electrode relative to the antenna; characterized in that a distance between a position of at least a portion of the antenna and the second end of the header is shorter than a distance between a position of the electrode and the second end of the header.
A seal system, comprising: a seal cavity defined, at least partially, by a first axial surface, a radial surface, and a second axial surface, wherein the second axial surface is recessed with respect to the first axial surface, and wherein the radial surface extends axially from the first axial surface to the second axial surface; and a brush seal disposed in the seal cavity, the brush seal comprising: a first bristle pack, the first bristle pack including a first group of bristles and a second group of bristles located radially outwards of the first group of bristles, wherein the radial surface is radially inwards of the second group of bristles, and a backing plate coupled to the first bristle pack, wherein the backing plate is radially inward of the first group of bristles; characterised in that the first group of bristles is radially inward of the first axial surface and the radial surface; in that the backing plate is radially inward of the first axial surface and the radial surface; and in that the second group of bristles contacts the first axial surface. a seal cavity defined, at least partially, by a first axial surface, a radial surface, and a second axial surface, wherein the second axial surface is recessed with respect to the first axial surface, and wherein the radial surface extends axially from the first axial surface to the second axial surface; and a brush seal disposed in the seal cavity, the brush seal comprising: a first bristle pack, the first bristle pack including a first group of bristles and a second group of bristles located radially outwards of the first group of bristles, wherein the radial surface is radially inwards of the second group of bristles, and a backing plate coupled to the first bristle pack, wherein the backing plate is radially inward of the first group of bristles; a first bristle pack, the first bristle pack including a first group of bristles and a second group of bristles located radially outwards of the first group of bristles, wherein the radial surface is radially inwards of the second group of bristles, and a backing plate coupled to the first bristle pack, wherein the backing plate is radially inward of the first group of bristles; characterised in that the first group of bristles is radially inward of the first axial surface and the radial surface; in that the backing plate is radially inward of the first axial surface and the radial surface; and in that the second group of bristles contacts the first axial surface.
Method for surface treating a substrate (4, 28) by means of an electrical corona discharge, wherein aerosols are sprayed during the discharge into the discharge region defined by an active gap formed between a corona electrode and the substrate (4, 28), characterized in that the spraying of the aerosols takes place substantially against the direction of gravity and in that the substrate (4, 28) is moved during the discharge in passage in continuous contact with a carrier surface of a carrier electrode below an imaginary horizontal plane guided through the carrier electrode.
A method comprising: receiving, by a station device, at least a portion of a beacon from a source by at least one antenna; allocating resources to perform beamforming; beamforming, by the station device, after receiving the at least a portion of the beacon and prior to receipt of an association request acceptance signal; and utilizing, by the station device, a directional configuration to communicate at least a portion of an association request that occurs in response to the beamforming; wherein at least a portion of the association request is transmitted in a directional mode. receiving, by a station device, at least a portion of a beacon from a source by at least one antenna; allocating resources to perform beamforming; beamforming, by the station device, after receiving the at least a portion of the beacon and prior to receipt of an association request acceptance signal; and utilizing, by the station device, a directional configuration to communicate at least a portion of an association request that occurs in response to the beamforming; wherein at least a portion of the association request is transmitted in a directional mode.
A process for preparing 2-amino-isonicotinic acid derivatives of formula I in which R1 is C 1 -C 6 -alkyl- or C 6 -C 10 -aryl-; R2 is H-, C 1 -C 6 -alkyl- or C 6 -C 10 -aryl-; or R1 and R2 together form a C 2 -C 5 -alkyl- group such that a ring is formed; R3 is C 1 -C 4 -alkyl-; R4 is C 1 -C 4 -alkyl-; comprising the reaction of compound with a compound of formula II in which R1, R2, R3 and R4 have the meaning as in formula I, in which water is eliminated. R1 is C 1 -C 6 -alkyl- or C 6 -C 10 -aryl-; R2 is H-, C 1 -C 6 -alkyl- or C 6 -C 10 -aryl-; or R1 and R2 together form a C 2 -C 5 -alkyl- group such that a ring is formed; R3 is C 1 -C 4 -alkyl-; R4 is C 1 -C 4 -alkyl-;
A polypeptide for use in treating or preventing congestive heart failure in a human, wherein the polypeptide comprises an epidermal growth factor-like (EGF-like) domain of recombinant human glial growth factor 2, wherein the congestive heart failure results from exposure to a cardiotoxic compound selected from the group consisting of anthracycline, anti-ErbB2 antibody and anti-HER2 antibody, wherein the polypeptide is suitable for administration in an amount effective to treat or prevent congestive heart failure in the human. wherein the polypeptide comprises an epidermal growth factor-like (EGF-like) domain of recombinant human glial growth factor 2, wherein the congestive heart failure results from exposure to a cardiotoxic compound selected from the group consisting of anthracycline, anti-ErbB2 antibody and anti-HER2 antibody, wherein the polypeptide is suitable for administration in an amount effective to treat or prevent congestive heart failure in the human.
A blood washing system, comprising: a rotor defining an internal chamber for receiving a multi-component fluid, the rotor being rotatable about a rotational axis (x-x) at a first speed to fractionate the multi-component fluid into a plurality of fractions; and a skimmer assembly including at least one buoy moveable along a buoy track positioned within the internal chamber, wherein the buoy defines an orifice fluidly connected to an access port in the rotor; wherein the buoy comprises a specific gravity corresponding to a selected fraction of the plurality of fractions such that the buoy floats on the selected fraction; wherein the buoy track extends radially outward from the rotational axis (x-x) of the rotor such that the buoy moves radially outward from the rotational axis (x-x) along the buoy track; and wherein the buoy track is oriented downward such that the buoy moves downward as the buoy moves radially outward from the rotational axis (x-x) along the buoy track. a rotor defining an internal chamber for receiving a multi-component fluid, the rotor being rotatable about a rotational axis (x-x) at a first speed to fractionate the multi-component fluid into a plurality of fractions; and a skimmer assembly including at least one buoy moveable along a buoy track positioned within the internal chamber, wherein the buoy defines an orifice fluidly connected to an access port in the rotor; wherein the buoy comprises a specific gravity corresponding to a selected fraction of the plurality of fractions such that the buoy floats on the selected fraction; wherein the buoy track extends radially outward from the rotational axis (x-x) of the rotor such that the buoy moves radially outward from the rotational axis (x-x) along the buoy track; and wherein the buoy track is oriented downward such that the buoy moves downward as the buoy moves radially outward from the rotational axis (x-x) along the buoy track.
Transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing self-adhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive based on polysiloxanes or polyisobutylenes, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, c) a viscosity-increasing substance in an amount of 0.1% to 8% of said buprenorphine-containing pressure-sensitive adhesive layer, and d) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture including said viscosity-increasing substance, and wherein the carboxylic acid-, buprenorphine- and viscosity-increasing substance-containing mixture forms dispersed deposits in the said pressure-sensitive adhesive, and wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer. A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive based on polysiloxanes or polyisobutylenes, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, c) a viscosity-increasing substance in an amount of 0.1% to 8% of said buprenorphine-containing pressure-sensitive adhesive layer, and d) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture including said viscosity-increasing substance, and wherein the carboxylic acid-, buprenorphine- and viscosity-increasing substance-containing mixture forms dispersed deposits in the said pressure-sensitive adhesive, and a) at least one polymer-based pressure-sensitive adhesive based on polysiloxanes or polyisobutylenes, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, c) a viscosity-increasing substance in an amount of 0.1% to 8% of said buprenorphine-containing pressure-sensitive adhesive layer, and d) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture including said viscosity-increasing substance, and wherein the carboxylic acid-, buprenorphine- and viscosity-increasing substance-containing mixture forms dispersed deposits in the said pressure-sensitive adhesive, and
A speaker device (1; 1a; 1b; 1c), comprising: a first speaker unit installed so as to be oriented upward; a head piece provided on an upper side of the first speaker unit and comprising a reflector configured to reflect a sound emitted by the first speaker unit, in a direction comprising a horizontal component; and a light emitting element installed between the first speaker unit and the head piece so as to be oriented toward the reflector, characterized in that the head piece comprises: a main body comprising a substantially cubic shape; and a skirt formed so as to surround a lower portion of the main body, wherein a bottom plate of the main body is formed with an opening comprising a diameter substantially identical to that of an opening of the first speaker unit, wherein a sound emission opening is formed in adjacent two side surfaces (111, 112) of four side surfaces (111, 112, 113, 114) of the main body, and a back board configured to limit a direction of propagation of the sound is formed at other two side surfaces (113, 114) of the four side surfaces (111, 112, 113, 114) which are different from the adjacent two side surfaces (111, 112), and wherein the light emitting element is installed at a sound-emission-opening-side corner portion inside the skirt between the bottom plate and the first speaker unit. a first speaker unit installed so as to be oriented upward; a head piece provided on an upper side of the first speaker unit and comprising a reflector configured to reflect a sound emitted by the first speaker unit, in a direction comprising a horizontal component; and a light emitting element installed between the first speaker unit and the head piece so as to be oriented toward the reflector, characterized in that the head piece comprises: a main body comprising a substantially cubic shape; and a skirt formed so as to surround a lower portion of the main body, wherein a bottom plate of the main body is formed with an opening comprising a diameter substantially identical to that of an opening of the first speaker unit, wherein a sound emission opening is formed in adjacent two side surfaces (111, 112) of four side surfaces (111, 112, 113, 114) of the main body, and a back board configured to limit a direction of propagation of the sound is formed at other two side surfaces (113, 114) of the four side surfaces (111, 112, 113, 114) which are different from the adjacent two side surfaces (111, 112), and wherein the light emitting element is installed at a sound-emission-opening-side corner portion inside the skirt between the bottom plate and the first speaker unit.
A substrate for multiple releases of active agents comprising a first polymer matrix layer having at least a first active agent disposed therein; a second polymer matrix layer having at least a second active agent disposed therein; and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer, wherein the coacervate layer comprises an anionic surfactant and a cationic surfactant, and wherein the substrate is a wrap accessory adapted to be placed around the outer surface of a medical device.
A method for configuring a touch screen keyboard in an electronic device, the method comprising: identifying a first type of application and a second type of application which the first type of application and the second type of application are running in the electronic device (302, 402); receiving an input event from at least one of the first type of application and the second type of application; generating the touch screen keyboard based on the first type of application and the second type of application in response to the input event; and displaying the touch screen keyboard on the screen of the electronic device wherein the touch screen keyboard includes at least one button which is providing function associated with the first type of application and the second type of application for interacting with the first type of application and the second type of application. identifying a first type of application and a second type of application which the first type of application and the second type of application are running in the electronic device (302, 402); receiving an input event from at least one of the first type of application and the second type of application; generating the touch screen keyboard based on the first type of application and the second type of application in response to the input event; and displaying the touch screen keyboard on the screen of the electronic device
A method implemented by a cloud-based controller to control a Wi-Fi network comprising a plurality of access points (14, 34), the method comprising the steps of: obtaining measurements from the plurality of access points (14, 34) comprised in the Wi-Fi network; determining a configuration of the plurality of access points (14, 34) comprised in the Wi-Fi network based on the measurements including the cloud-based controller determining a topology to be applied to the Wi-Fi network, wherein the cloud-based controller determining the topology includes selecting an interconnectivity of the plurality of access points to another via backhaul links that are wireless links; and providing the configuration as operational parameters to the plurality of access points (14, 34) comprised in the Wi-Fi network for implementation thereof, characterized in that the determining a topology further comprises the cloud-based controller selecting the topology of connection between the plurality of access points (14, 34) via wireless backhaul links and to any client devices via wireless client links, wherein the wireless backhaul links are different from the wireless client links and the wireless backhaul links form a tree topology, one of the plurality of access points (14, 34) being configured as a gateway connected to the Internet and the cloud-based controller communicating with the one access point configured as the gateway via the Internet; and selecting an interconnectivity of a plurality of client devices and the plurality of access points via selection of Wi-Fi channels for client links, the client links using different Wi-Fi channels than the backhaul links. obtaining measurements from the plurality of access points (14, 34) comprised in the Wi-Fi network; determining a configuration of the plurality of access points (14, 34) comprised in the Wi-Fi network based on the measurements including the cloud-based controller determining a topology to be applied to the Wi-Fi network, wherein the cloud-based controller determining the topology includes selecting an interconnectivity of the plurality of access points to another via backhaul links that are wireless links; and providing the configuration as operational parameters to the plurality of access points (14, 34) comprised in the Wi-Fi network for implementation thereof, characterized in that the determining a topology further comprises the cloud-based controller selecting the topology of connection between the plurality of access points (14, 34) via wireless backhaul links and to any client devices via wireless client links, wherein the wireless backhaul links are different from the wireless client links and the wireless backhaul links form a tree topology, one of the plurality of access points (14, 34) being configured as a gateway connected to the Internet and the cloud-based controller communicating with the one access point configured as the gateway via the Internet; and selecting an interconnectivity of a plurality of client devices and the plurality of access points via selection of Wi-Fi channels for client links, the client links using different Wi-Fi channels than the backhaul links.
A composite charged particle beams apparatus comprising: an electron beam column for observing a sample's cross-section, an ion-beam column for forming said sample's cross-section, and a detector for detecting low-loss back-scattered electrons including elastically-scattered electrons, said low-loss back-scattered electrons being induced by said electron beam with which said sample's cross-section is irradiated, characterised in that said detector is deployed in a three-dimensional area which is oriented in a direction, said direction being implemented as a result of a 90° or-more rotation from an axis of said ion-beam incident into said cross-section such that a cross point of said ion beam and said electron beam is employed as a center of said rotation. an electron beam column for observing a sample's cross-section, an ion-beam column for forming said sample's cross-section, and a detector for detecting low-loss back-scattered electrons including elastically-scattered electrons, said low-loss back-scattered electrons being induced by said electron beam with which said sample's cross-section is irradiated, characterised in that said detector is deployed in a three-dimensional area which is oriented in a direction, said direction being implemented as a result of a 90° or-more rotation from an axis of said ion-beam incident into said cross-section such that a cross point of said ion beam and said electron beam is employed as a center of said rotation.