A honeycomb-shaped ceramic separation-membrane structure comprising: a ceramic porous body including a honeycomb-shaped base material and an intermediate layer; and a separation layer for separating a mixture, wherein the base material has partition walls of the ceramic porous body having a large number of pores formed therein and a plurality of cells formed by the partition walls and functioning as passages for a fluid passing through the ceramic porous body, the intermediate layer of the ceramic porous body has a large number of pores having a small average pore diameter in comparison with a surface of the base material and is disposed on the surface of the base material, the intermediate layer thickness, which is the thickness of the intermediate layer, is 100 μm or more and 500 μm or less, and the separation layer is provided on a surface of the intermediate layer of the ceramic porous body, at least a part of the base material and the intermediate layer has a structure where aggregate particles are bonded to one another by an inorganic bonding material component, the aggregate particles of the base material are one selected from the group consisting of alumina, titania, mullite, powder of potsherd, and cordierite, the inorganic bonding material component of the base material is one selected from the group consisting of easily-sinterable alumina, silica, glass frit, clay mineral, and easily-sinterable cordierite, the aggregate particles of the intermediate layer are one selected from the group consisting of alumina, titania, mullite, powder of potsherd, and cordierite, the inorganic bonding material component of the intermediate layer is one selected from the group consisting of easily-sinterable alumina, silica, glass frit, clay mineral, and easily-sinterable cordierite, the base material thickness, which is the thickness of the base material excluding the intermediate layer and the separation layer at the shortest portion of all partition walls between the cells, is 0.51 mm or more and 1.55 mm or less, and the ratio of the base material thickness to the intermediate layer thickness is 2.5 or more, characterized in that the proportion of the inorganic bonding material component in the inorganic solid content of the intermediate layer is 26% by mass or more and 42% by mass or less, and the separation layer is formed of zeolite. a ceramic porous body including a honeycomb-shaped base material and an intermediate layer; and a separation layer for separating a mixture, wherein the base material has partition walls of the ceramic porous body having a large number of pores formed therein and a plurality of cells formed by the partition walls and functioning as passages for a fluid passing through the ceramic porous body, the intermediate layer of the ceramic porous body has a large number of pores having a small average pore diameter in comparison with a surface of the base material and is disposed on the surface of the base material, the intermediate layer thickness, which is the thickness of the intermediate layer, is 100 μm or more and 500 μm or less, and the separation layer is provided on a surface of the intermediate layer of the ceramic porous body, at least a part of the base material and the intermediate layer has a structure where aggregate particles are bonded to one another by an inorganic bonding material component, the aggregate particles of the base material are one selected from the group consisting of alumina, titania, mullite, powder of potsherd, and cordierite, the inorganic bonding material component of the base material is one selected from the group consisting of easily-sinterable alumina, silica, glass frit, clay mineral, and easily-sinterable cordierite, the aggregate particles of the intermediate layer are one selected from the group consisting of alumina, titania, mullite, powder of potsherd, and cordierite, the inorganic bonding material component of the intermediate layer is one selected from the group consisting of easily-sinterable alumina, silica, glass frit, clay mineral, and easily-sinterable cordierite, the base material thickness, which is the thickness of the base material excluding the intermediate layer and the separation layer at the shortest portion of all partition walls between the cells, is 0.51 mm or more and 1.55 mm or less, and the ratio of the base material thickness to the intermediate layer thickness is 2.5 or more, characterized in that the proportion of the inorganic bonding material component in the inorganic solid content of the intermediate layer is 26% by mass or more and 42% by mass or less, and the separation layer is formed of zeolite.