A thick steel sheet excellent in fatigue properties comprising, by mass%, 0.010 to 0.1% of C, more than 0% and 0.3% or less of Si, 1.0 to 2% of Mn, 0.5 to 2% of Cr, 0.005 to 1.5% of Mo, and 0.0005 to 0.005% of B, respectively, and comprising one or more elements selected from 0.1 to 1.0% of Cu, and 0.1 to 1.0% of Ni, and one or more element selected from the group consisting of 0.05% or less of V, 0.05% or less of Nb, and 0.05% or less of Ti, and optionally further comprises more than 0% and 0.005% or less Ca, more than 0% and 0.10% or less Al, and more than 0% and 0.010% or less of N, in which the elements satisfy the relation of the following formulas to, and the remainder of iron and inevitable impurities, in which the micro structure satisfies the following requirements, (a) to (d) when measured at an observation position at a depth of 3 mm from the surface of a steel sheet for a vertical cross section parallel to a rolling direction, and precipitates satisfy the following requirement: 0.01 ≤ Nb + 2 Ti + 2 V ≤ 0.10 (where [Nb], [Ti], and represent respectively the contents of Nb, Ti and V in the steel sheet on the mass% base), 0 ≤ Cu + Ni − 2 Si ≤ 1.0 (where [Cu], [Ni] and [Si] represent respectively the contents of Cu, Ni, and Si in the steel sheet on the mass% base), and 2.4 ≤ Mn + 1.5 Cr + 2 Mo ≤ 4.5 (where [Mn], [Cr] and [Mo] represent respectively the contents of Mn, Cr, and Mo in the steel sheet on the basis of mass%), (a) the micro structure comprises a bainitic structure and a remaining microstructure harder than the bainite where the bainitic fraction is 80 area% or more in the whole microstructure, (b) when the crystal grain size of the bainite is determined based on a high-angle grain boundary having an orientation difference between adjacent crystals of 15° or greater, an average length of the crystal grains in the direction of the sheet thickness is 7 μm or less, (c) a circle equivalent diameter of a harder remaining microstructure is 3 μm or less, and (d) a difference of hardness between the bainite and the harder remaining microstructure (hardness of the harder remaining microstructure - hardness of the bainite) is Hv 100 or more, and the number of precipitates containing at least one of Nb, Ti, and V each having a circle equivalent diameter of 20 nm or less is 100 N/μm 2 or more. (a) the micro structure comprises a bainitic structure and a remaining microstructure harder than the bainite where the bainitic fraction is 80 area% or more in the whole microstructure, (b) when the crystal grain size of the bainite is determined based on a high-angle grain boundary having an orientation difference between adjacent crystals of 15° or greater, an average length of the crystal grains in the direction of the sheet thickness is 7 μm or less, (c) a circle equivalent diameter of a harder remaining microstructure is 3 μm or less, and (d) a difference of hardness between the bainite and the harder remaining microstructure (hardness of the harder remaining microstructure - hardness of the bainite) is Hv 100 or more, and the number of precipitates containing at least one of Nb, Ti, and V each having a circle equivalent diameter of 20 nm or less is 100 N/μm 2 or more.