A compound of the formula: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein: R 1 is -NR 4 R 5; R 2 is selected from the group consisting of: H, (C 6 -C 10)aryl-(C 1 -C 3 alkyl)-heterocycloalkyl-, -(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-heterocycloalkyl-(C 6 -C 10 aryl), -(C 1 -C 4 alkyl)(C 6 -C 10)aryl, -(C 1 -C 3 alkyl)heteroaryl, -(C 3 -C 6 cycloalkyl)- (C 6 -C 10 aryl), -heterocycloalkyl-(C 6 -C 10 aryl); and wherein said aryl, heterocycloalkyl, heteroaryl, and cycloalkyl moieties of said R 2 groups are optionally substituted with 1-3 substituents independently selected from the group consisting of: halo, -O-(C 1 -C 6 alkyl), -OH, -CF 3, and -(C 1 -C 6 alkyl); and wherein said alkyl moieties of said R 2 groups are optionally substituted with 1-3 substituents independently selected from the group consisting of: halo (e.g., F, Br, and Cl), -O-(C 1 -C 6 alkyl), -OH and -CF 3; R 4 and R 5 are each independently selected from the group consisting of: H, -(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -C R 8, -S 2 R 9; or R 4 and R 5 taken together with the nitrogen to which they are bonded to form a 4-6 membered heterocycloalkyl ring, said ring optionally comprising 1 or 2 additional heteroatoms independently selected from the group consisting of: O, S and N, and said ring is optionally substituted with 1-3 substituents independently selected from the group consisting of: -O(C 1 -C 6 alkyl) and -(C 1 -C 6 alkyl), - R 8 and R 9 are each independently selected from the group consisting of: -(C 1 -C 6 alkyl), - (C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -(C 3 -C 6)cycloalkyl, -(C 1 -C 6 alkyl)-(C 3 -C 6)cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein said heterocycloalkyl is a 4-6 membered ring comprising 1-3 heteroatoms selected from the group consisting of: O, S and N and the remaining ring atoms are carbon, and wherein said aryl is a C 6 to C 10 aromatic ring, and wherein said heteroaryl is a 5 to 10 membered ring comprising 1-3 heteroatoms selected from the group consisting of: O, S and N and the remaining ring atoms are carbon; and R 10 and R 11 are each independently selected from the group consisting of: H, halo, -(C 1 to C 6 alkyl), -(C 3 -C 6 cycloalkyl), hydroxy substituted -(C 1 -C 6 alkyl), -(C 1 -C 6 akyl)-O-(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-N(C 1 -C 6 alkyl) 2 wherein each alkyl is independently selected, and -(C 1 -C 6 alkyl)-heterocycloalkyl. R 1 is -NR 4 R 5; R 2 is selected from the group consisting of: H, (C 6 -C 10)aryl-(C 1 -C 3 alkyl)-heterocycloalkyl-, -(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-heterocycloalkyl-(C 6 -C 10 aryl), -(C 1 -C 4 alkyl)(C 6 -C 10)aryl, -(C 1 -C 3 alkyl)heteroaryl, -(C 3 -C 6 cycloalkyl)- (C 6 -C 10 aryl), -heterocycloalkyl-(C 6 -C 10 aryl); and wherein said aryl, heterocycloalkyl, heteroaryl, and cycloalkyl moieties of said R 2 groups are optionally substituted with 1-3 substituents independently selected from the group consisting of: halo, -O-(C 1 -C 6 alkyl), -OH, -CF 3, and -(C 1 -C 6 alkyl); and wherein said alkyl moieties of said R 2 groups are optionally substituted with 1-3 substituents independently selected from the group consisting of: halo (e.g., F, Br, and Cl), -O-(C 1 -C 6 alkyl), -OH and -CF 3; R 4 and R 5 are each independently selected from the group consisting of: H, -(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -C R 8, -S 2 R 9; or R 4 and R 5 taken together with the nitrogen to which they are bonded to form a 4-6 membered heterocycloalkyl ring, said ring optionally comprising 1 or 2 additional heteroatoms independently selected from the group consisting of: O, S and N, and said ring is optionally substituted with 1-3 substituents independently selected from the group consisting of: -O(C 1 -C 6 alkyl) and -(C 1 -C 6 alkyl), - R 8 and R 9 are each independently selected from the group consisting of: -(C 1 -C 6 alkyl), - (C 1 -C 6 alkyl)-O-(C 1 -C 6 alkyl), -(C 3 -C 6)cycloalkyl, -(C 1 -C 6 alkyl)-(C 3 -C 6)cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein said heterocycloalkyl is a 4-6 membered ring comprising 1-3 heteroatoms selected from the group consisting of: O, S and N and the remaining ring atoms are carbon, and wherein said aryl is a C 6 to C 10 aromatic ring, and wherein said heteroaryl is a 5 to 10 membered ring comprising 1-3 heteroatoms selected from the group consisting of: O, S and N and the remaining ring atoms are carbon; and R 10 and R 11 are each independently selected from the group consisting of: H, halo, -(C 1 to C 6 alkyl), -(C 3 -C 6 cycloalkyl), hydroxy substituted -(C 1 -C 6 alkyl), -(C 1 -C 6 akyl)-O-(C 1 -C 6 alkyl), -(C 1 -C 6 alkyl)-N(C 1 -C 6 alkyl) 2 wherein each alkyl is independently selected, and -(C 1 -C 6 alkyl)-heterocycloalkyl.