mhurhangee/ep-ind-claims huggingface dataset:
A variant Fc-polypeptide comprising a human IgG 1, IgG2, IgG3, or IgG4 variant Fc-fragment; wherein the variant Fc-fragment comprises an insertion of 3 to 20 amino acids in comparison to a control Fc-fragment, wherein the insertion into the variant Fc-fragment is an insertion into an amino acid sequence corresponding to a portion of the control Fc-fragment selected from: (a) amino acids 383-387 using the EU numbering system shown in Table 1, (b) amino acids 383-387 using the EU numbering system shown in Table 1, wherein amino acids 384-386 are deleted, and (c) amino acids 382-391 using the EU numbering system shown in Table 1, wherein the insertion is between amino acids 382 and 383, 383 and 384, 384 and 385, 385 and 386, 386 and 387, 387 and 388, 388 and 389, 389 and 390, or 390 and 391; wherein the control Fc-fragment comprises an amino acid sequence selected from: amino acids 169-175 of SEQ ID NO:1 (IgG1 Fc-fragment), amino acids 165-171 of SEQ ID NO:3 (IgG2 Fc-fragment), amino acids 216-222 of SEQ ID NO:5 (IgG3 Fc-fragment), and amino acids 166-172 of SEQ ID NO:7 (IgG4 Fc-fragment); wherein the control Fc-polypeptide comprises the control Fc-fragment and has the same amino acid sequence as the variant Fc-polypeptide except that the control Fc-polypeptide does not contain the insertion of 3 to 20 amino acids; wherein the variant Fc-polypeptide binds to a human neonatal Fc receptor (hFcRn) with higher binding activity at pH 6.0 than the control Fc-polypeptide; wherein the variant Fc-polypeptide has little or no binding activity for binding to hFcRn at pH 7.4 and the residual binding response detected at pH 7.4 is no more than 0,2 nanometer more than that detected using the control Fc-polypeptide; and wherein the comparative values for binding activity and residual binding response are determined by bio-layer interferometry. (a) amino acids 383-387 using the EU numbering system shown in Table 1, (b) amino acids 383-387 using the EU numbering system shown in Table 1, wherein amino acids 384-386 are deleted, and (c) amino acids 382-391 using the EU numbering system shown in Table 1, wherein the insertion is between amino acids 382 and 383, 383 and 384, 384 and 385, 385 and 386, 386 and 387, 387 and 388, 388 and 389, 389 and 390, or 390 and 391; wherein the control Fc-fragment comprises an amino acid sequence selected from: amino acids 169-175 of SEQ ID NO:1 (IgG1 Fc-fragment), amino acids 165-171 of SEQ ID NO:3 (IgG2 Fc-fragment), amino acids 216-222 of SEQ ID NO:5 (IgG3 Fc-fragment), and amino acids 166-172 of SEQ ID NO:7 (IgG4 Fc-fragment); amino acids 169-175 of SEQ ID NO:1 (IgG1 Fc-fragment), amino acids 165-171 of SEQ ID NO:3 (IgG2 Fc-fragment), amino acids 216-222 of SEQ ID NO:5 (IgG3 Fc-fragment), and amino acids 166-172 of SEQ ID NO:7 (IgG4 Fc-fragment);
A computer-implemented method comprising: receiving historic traffic data associated with a road network in a geographic area; partitioning the historic traffic data based on a plurality of predefined speed data ranges; analyzing the historic traffic data within each speed data range separately to generate a plurality of speed profiles; assigning each speed profile a unique identifier; associating the plurality of speed profiles to location codes that reference physical locations on the road network and day codes that reference days of a week; and providing a lookup table that references the speed profile identifier by the location code and the day code. receiving historic traffic data associated with a road network in a geographic area; partitioning the historic traffic data based on a plurality of predefined speed data ranges; analyzing the historic traffic data within each speed data range separately to generate a plurality of speed profiles; assigning each speed profile a unique identifier; associating the plurality of speed profiles to location codes that reference physical locations on the road network and day codes that reference days of a week; and providing a lookup table that references the speed profile identifier by the location code and the day code.
A diameter-variable cylindrical air pressure spring, comprising a spring body, formed by at least one hollow cavity body, wherein a sidewall of the cavity body is of a multilayered structure, a closed cavity containing pressure air is formed between every two layers of the sidewall, the cavity body is in a diameter-variable cylindrical shape with two thicker ends and a thinner middle part, and a vent hole is arranged on each cavity; characterized in that a plurality of air holes transversely penetrating through the cavity are arranged on the sidewall of the cavity body.
Arrangement for transport protection of an actuating linkage of an actuating pedal in a motor vehicle, comprising - a master cylinder, at one end of which is arranged a stop ring for a piston standing under the pressure of a spring in the cylinder housing, and - an essentially axially actuated piston rod, the spherical foot of which passes through a central bore of the stop ring and acts upon the piston head, - and a lock limiting the radial rotation of the piston is arranged between the piston and the stop ring, characterized in that a rotational securing means for the purpose of common radial rotation is arranged between the foot of the piston rod and the piston. - a master cylinder, at one end of which is arranged a stop ring for a piston standing under the pressure of a spring in the cylinder housing, and - an essentially axially actuated piston rod, the spherical foot of which passes through a central bore of the stop ring and acts upon the piston head, - and a lock limiting the radial rotation of the piston is arranged between the piston and the stop ring,
A terminal comprising: a coding section that separately encodes first uplink control information, UCI, and second UCI, wherein the first UCI includes transmission acknowledgement information of a downlink shared channel in at least one cell, and the second UCI includes channel state information in at least one cell; and a transmission section that transmits the first UCI and the second UCI using an uplink control channel, wherein, in each slot, an encoded bit sequence of the first UCI is mapped to a first symbol set of the uplink control channel without being multiplexed with an encoded bit sequence of the second UCI, and both of an encoded bit sequence of the first UCI and the encoded bit sequence of the second UCI are mapped to a second symbol set of the uplink control channel different from the first symbol set, wherein, in each slot, two symbols of the second symbol set are adjacent to the first symbol set, and subcarriers and symbols of the first UCI are determined according to a predetermined pattern based on the number of bits after encoding of the first UCI. a coding section that separately encodes first uplink control information, UCI, and second UCI, wherein the first UCI includes transmission acknowledgement information of a downlink shared channel in at least one cell, and the second UCI includes channel state information in at least one cell; and a transmission section that transmits the first UCI and the second UCI using an uplink control channel, wherein, in each slot, an encoded bit sequence of the first UCI is mapped to a first symbol set of the uplink control channel without being multiplexed with an encoded bit sequence of the second UCI, and both of an encoded bit sequence of the first UCI and the encoded bit sequence of the second UCI are mapped to a second symbol set of the uplink control channel different from the first symbol set, wherein, in each slot, two symbols of the second symbol set are adjacent to the first symbol set, and subcarriers and symbols of the first UCI are determined according to a predetermined pattern based on the number of bits after encoding of the first UCI.
A method of controlling an additive manufacturing apparatus to generate a three dimensional object, the method comprising: processing successive layers of build material so as to form successive layers of a three dimensional object, wherein the processing of each layer is performed within a predetermined layer processing time by a plurality of components; selecting, by at least one processor, from a plurality of ancillary tasks, at least one ancillary task to be performed in relation to at least one component of the plurality of components in addition to the processing of layers of build material; and scheduling, by at least one processor, the at least one ancillary task to be performed in relation to the at least one component within the predetermined layer processing time for a single layer or for multiple layers of the build material. processing successive layers of build material so as to form successive layers of a three dimensional object, wherein the processing of each layer is performed within a predetermined layer processing time by a plurality of components; selecting, by at least one processor, from a plurality of ancillary tasks, at least one ancillary task to be performed in relation to at least one component of the plurality of components in addition to the processing of layers of build material; and scheduling, by at least one processor, the at least one ancillary task to be performed in relation to the at least one component within the predetermined layer processing time for a single layer or for multiple layers of the build material.
A support assembly (102, 802) to movably support a device (100, 808), comprising: a base (106, 804); an arm (104, 806); and a hinge assembly (216, 900) to pivotably couple the arm (104, 806) to the base (106, 804), wherein the hinge assembly (216, 900) comprises: a rotatable cam (402, 910); a link (314, 908) attached to the rotatable cam (402, 910), wherein a portion of the link (314, 908) is windable about the profile of the cam (402, 910) as the cam (402, 910) rotates; and a biasing assembly (304, 814) comprising a linear spring, the biasing assembly (304, 814) being attached to the link (314, 908) to apply to biasing force on the link (314, 908), wherein the arm has a hinge, to pivotably attach the device to the arm (104, 806), characterized in that a torsional spring is comprised in the hinge assembly (216, 900), to apply biasing force in conjunction with the linear spring of the biasing assembly (304, 814), and further characterized in that the profile of the rotatable cam (402, 910) is non-circular. a base (106, 804); an arm (104, 806); and a hinge assembly (216, 900) to pivotably couple the arm (104, 806) to the base (106, 804), wherein the hinge assembly (216, 900) comprises: a rotatable cam (402, 910); a link (314, 908) attached to the rotatable cam (402, 910), wherein a portion of the link (314, 908) is windable about the profile of the cam (402, 910) as the cam (402, 910) rotates; and a biasing assembly (304, 814) comprising a linear spring, the biasing assembly (304, 814) being attached to the link (314, 908) to apply to biasing force on the link (314, 908), wherein the arm has a hinge, to pivotably attach the device to the arm (104, 806), a rotatable cam (402, 910); a link (314, 908) attached to the rotatable cam (402, 910), wherein a portion of the link (314, 908) is windable about the profile of the cam (402, 910) as the cam (402, 910) rotates; and a biasing assembly (304, 814) comprising a linear spring, the biasing assembly (304, 814) being attached to the link (314, 908) to apply to biasing force on the link (314, 908), wherein the arm has a hinge, to pivotably attach the device to the arm (104, 806), characterized in that a torsional spring is comprised in the hinge assembly (216, 900), to apply biasing force in conjunction with the linear spring of the biasing assembly (304, 814), and further characterized in that the profile of the rotatable cam (402, 910) is non-circular.
A process for carrying out an oxidation treatment of a non-ferrous metal component, comprising placing the component into a process chamber at an elevated temperature in the range 600°C to 800°C, biasing the component to have a potential capable of attracting ions, introducing oxygen into the chamber at a pressure such that a glow discharge comprising oxygen ions is generated, the process chamber additionally comprising a glow discharge ionisation enhancing means, and activating the glow discharge ionisation enhancing means thereby increasing charged species density of the glow discharge, the oxygen ions flowing towards the component and colliding the surface thereof, at least some of which diffuse into the component, forming oxides therein.
Enclosure assembly for at least one connector, comprising: an enclosure, the enclosure having a connector volume configured to receive the connector and an opening at least at a rearward end, a strain relief element being adapted to receive a cable, the strain relief element being provided with a relief portion at one end, the relief portion being configured to support the cable elastically, and with a fastening portion, the fastening portion in a mounted state being arranged at least partially within the opening and affixing the strain relief element to the enclosure, whereby, in a pre-mounted state, the enclosure and the strain relief element are adapted to be slid relative to each other, wherein the enclosure is arranged slidable on the strain relief along the strain relief in a forward direction up to a forward position, characterised in that the enclosure comprises an inner body and an outer body, said inner body is provided with a clamping section, which opens in the rearward direction and is radially elastic for sealing the connector volume at the rearward end in the forward position. an enclosure, the enclosure having a connector volume configured to receive the connector and an opening at least at a rearward end, a strain relief element being adapted to receive a cable, the strain relief element being provided with a relief portion at one end, the relief portion being configured to support the cable elastically, and with a fastening portion, the fastening portion in a mounted state being arranged at least partially within the opening and affixing the strain relief element to the enclosure, whereby, in a pre-mounted state, the enclosure and the strain relief element are adapted to be slid relative to each other, wherein the enclosure is arranged slidable on the strain relief along the strain relief in a forward direction up to a forward position, characterised in that the enclosure comprises an inner body and an outer body, said inner body is provided with a clamping section, which opens in the rearward direction and is radially elastic for sealing the connector volume at the rearward end in the forward position.
A printing device of the 3D printer type for additive manufacturing from materials of the polymer type in the form of fusible granules, the printing device comprising means for heating the granules to obtain a molten material, means for supplying the molten material up to a print head comprising at its outlet a print nozzle, the supply means comprising a worm screw driven by a motor, the shaft of the worm screw and the shaft of the motor being different and spaced apart from each other, a drive mechanism arranged between the shaft of the motor and the shaft of the worm screw so that the rotation of the shaft of the motor drives that of the shaft of the worm screw, characterised in that said printing device comprises a first fan arranged at the end portion of the drive mechanism coupled to the shaft of the motor and a second fan arranged at the end portion of the drive mechanism coupled to the shaft of the worm screw.
Heat transfer device for the provision of refrigeration in refrigerated vehicles through the evaporation of liquefied natural gas, while the regasified natural gas (NG, on the one hand, is intended for powering the engine of the refrigerated vehicle, and the available refrigerating capacity, on the other hand, is usable for cooling the refrigerated goods to be transported by the refrigerated vehicle, by a heat exchanger arranged inside the cold room is operatively interacting, while preserving strict physical separation, with a heat exchanger located outside the cold room as an LNG evaporator, such that heat is removable from the cold room and extractable by means of fan-delivered cold room air and by means of the heat exchanger, i. e. by using a liquid intermediate medium that is conducted by forced circulation in a closed loop between heat exchanger and heat exchanger, that, being a synthetic heat transfer fluid based on aliphatic hydrocarbons, does not freeze and is pumpable down to -85°C, is harmless to the environment in case of leakage in the event of any incident, and is approved of for occasional and unintended contact with foodstuffs, characterized in that a heat exchanger made of tough-at-subzero material is used for evaporating the LNG flowing in via the LNG inlet, and conducts the LNG to be evaporated in the heat transfer tubes and the heat-transferring intermediate medium in the shell space from the inlet to the outlet, and is designed as a shell-and-tube heat exchanger with floating head and two shell paths, whereby the high temporal and local changes in temperature arising during operation exclusively cause controllable mechanical stresses, and while coaxially arranged protective tubes enclose the LNG-conducting heat transfer tubes thus forming an intermediate space which is hermetically closed, fillable with a dry gas, and has a low layer thickness between the tubes (18 and 21) which is designed so as to cause the thermal resistance (R th) here to bring about a drop in temperature which excludes any freezing of the intermediate medium at the surface of the protective tube.
A method for securing an infrastructure in a computer network against malicious attacks, comprising: - receiving network session information from at least one computing device over a computer network, the network session information containing computing instructions to be performed in a requested infrastructure; - scanning the requested infrastructure and emulating the requested infrastructure; - executing a duplicated network session information using the emulated infrastructure and recording the execution of the computing instructions in said emulated infrastructure, wherein the duplicated network session information is assigned a new identifier and the duplicated network session information is addressed using the new identifier and the original network session information remains in a secured area and is left unused; - storing the duplicated network session and the execution of the computing instructions as a signature information and comparing this signature information with previously established signature information, the previously established signature information being stored as a function of data transmissions from several computing devices and data transmissions to several requested infrastructures, thereby computing a security index; and - executing the computing instructions in the requested infrastructure as a function of the security index. - receiving network session information from at least one computing device over a computer network, the network session information containing computing instructions to be performed in a requested infrastructure; - scanning the requested infrastructure and emulating the requested infrastructure; - executing a duplicated network session information using the emulated infrastructure and recording the execution of the computing instructions in said emulated infrastructure, wherein the duplicated network session information is assigned a new identifier and the duplicated network session information is addressed using the new identifier and the original network session information remains in a secured area and is left unused; - storing the duplicated network session and the execution of the computing instructions as a signature information and comparing this signature information with previously established signature information, the previously established signature information being stored as a function of data transmissions from several computing devices and data transmissions to several requested infrastructures, thereby computing a security index; and - executing the computing instructions in the requested infrastructure as a function of the security index.
A rotary dental abrasive assembly comprising: a unitary abrasive member having a generally circular receptacle with a minimum inner diameter when the abrasive member is relaxed, the member comprising a resilient polymer composite comprising abrasive particles; and a generally cylindrical mandrel having an outer surface, a longitudinal axis and a bulbous working end received in the receptacle, the working end having both concave and convex surfaces and the working end being divided into a plurality of sections by elongated slots extending from the outer surface of the mandrel toward the longitudinal axis, wherein the working end has an maximum outer diameter when relaxed and the plurality of sections and the abrasive member cooperatively deflect as the abrasive member is engaged to, and disengaged from, the mandrel, wherein the abrasive member contacts the mandrel along both concave and convex surfaces of the working end when the abrasive member is engaged to the mandrel. a unitary abrasive member having a generally circular receptacle with a minimum inner diameter when the abrasive member is relaxed, the member comprising a resilient polymer composite comprising abrasive particles; and a generally cylindrical mandrel having an outer surface, a longitudinal axis and a bulbous working end received in the receptacle, the working end having both concave and convex surfaces and the working end being divided into a plurality of sections by elongated slots extending from the outer surface of the mandrel toward the longitudinal axis, wherein the working end has an maximum outer diameter when relaxed and the plurality of sections and the abrasive member cooperatively deflect as the abrasive member is engaged to, and disengaged from, the mandrel, wherein the abrasive member contacts the mandrel along both concave and convex surfaces of the working end when the abrasive member is engaged to the mandrel.
A disintegrative particulate composition comprising: (i) milled lactose and/or granulated lactose as an excipient; (ii) micro-fibrillated cellulose; and (iii) one or more disintegrator components selected from crospovidone, croscarmellose sodium, low substituted hydroxypropylcellulose, carboxymethylcellulose calcium, starch, and processed starch. (i) milled lactose and/or granulated lactose as an excipient; (ii) micro-fibrillated cellulose; and (iii) one or more disintegrator components selected from crospovidone, croscarmellose sodium, low substituted hydroxypropylcellulose, carboxymethylcellulose calcium, starch, and processed starch.