A diagnostic device for detection of at least one protein in a biological sample of a mammal, comprising: a) a sample receiving material, wherein said sample receiving material is capable of receiving a biological sample; b) a detection reagent, wherein said detection reagent is reactive with at least one protein present in said biological sample; c) a trap, wherein said trap is in contact with the sample receiving material and wherein said trap is able to separate the detection reagent bound to said at least one protein in said biological sample from the detection reagent that is not bound to said at least one protein in said biological sample, whereby said detection reagent bound to said at least one protein in said biological sample is able to flow through said trap, and whereby said detection reagent that is not bound to said at least one protein in said biological sample is captured by said trap; d) a capillary bed, wherein said capillary bed is in contact with said trap, and wherein said capillary bed is configured to contain said biological sample after said biological sample flows through said trap, wherein said sample receiving material, said trap, and said capillary bed are configured to be in contact in sequence, wherein said capillary bed displays detection reagent if said at least one protein is present in said biological sample, and wherein said detection reagent binds to at least one protein selected from the group consisting of a misfolded protein, a protein aggregate, a supramolecular protein aggregate, a fragment of a misfolded protein, a fragment of a protein aggregate, a fragment of a supramolecular protein aggregate, mixtures thereof, and fragments of said mixtures. a) a sample receiving material, wherein said sample receiving material is capable of receiving a biological sample; b) a detection reagent, wherein said detection reagent is reactive with at least one protein present in said biological sample; c) a trap, wherein said trap is in contact with the sample receiving material and wherein said trap is able to separate the detection reagent bound to said at least one protein in said biological sample from the detection reagent that is not bound to said at least one protein in said biological sample, whereby said detection reagent bound to said at least one protein in said biological sample is able to flow through said trap, and whereby said detection reagent that is not bound to said at least one protein in said biological sample is captured by said trap; d) a capillary bed, wherein said capillary bed is in contact with said trap, and wherein said capillary bed is configured to contain said biological sample after said biological sample flows through said trap, wherein said sample receiving material, said trap, and said capillary bed are configured to be in contact in sequence, wherein said capillary bed displays detection reagent if said at least one protein is present in said biological sample, and wherein said detection reagent binds to at least one protein selected from the group consisting of a misfolded protein, a protein aggregate, a supramolecular protein aggregate, a fragment of a misfolded protein, a fragment of a protein aggregate, a fragment of a supramolecular protein aggregate, mixtures thereof, and fragments of said mixtures.