A compound of Formula III-A or a tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof; wherein A 4 is CR 4 or N; A 5 is CR 5 or N; A 6 is CR 6 or N; A 8 is CR 8 or N, provided that no more than one of A 4, A 5, A 6 and A 8 is N; R 3 is CH 3, CF 3, CH 2 F or CHF 2; each of R 4, R 5, R 6 and R 8, independently, is H, halo, haloalkyl, haloalkoxyl, C 1-4 -alkyl, CN, OH, OC 1-4 -alkyl, S o C 1-4 -alkyl, NHC 1-4 -alkyl or C C 1-4 -alkyl; R 7 is -NH-R 9, -NH-C(=O)-R 9, -C(=O)NH-R 9, -NH-C(=S)-R 9, -O-R 9 or -S-R 9; R 9 is acetyl, C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl or a fully or partially unsaturated 3-, 4-, 5-, 6- or 7-membered monocyclic or 8-, 9- or 10-membered bicyclic ring formed of carbon atoms, said ring optionally including 1-4 heteroatoms if monocyclic or 1-5 heteroatoms if bicyclic, said heteroatoms selected from O, N or S, wherein the C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl and ring are optionally substituted, independently, with 1-5 substituents of R 10; and each R 10, independently, is H, halo, haloalkyl, CN, OH, NO 2, NH 2, SF 5, acetyl, -C NHCH 3, oxo, cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl, piperazinyl, oxetan-3-yl, imidazo-pyridinyl or dioxolyl, wherein each of the cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetan-3-yl or dioxolyl, is optionally substituted independently with 1-5 substituents of F, Cl, CN, NO 2, NH 2, OH, oxo, CF 3, CHF 2, CH 2 F, methyl, methoxy, ethyl, ethoxy, CH 2 CF 3, CH 2 CHF 2, propyl, propoxy, isopropyl, isopropoxy, cyclopropyl, butyl, butoxyl, cyclobutyl, isobutoxy, tert-butoxy, isobutyl, sec-butyl, tert-butyl, C 1-3 alkylamino-, C 1-3 dialkylamino, C 1-3 thioalkoxyl, oxazolyl, or oxetan-3yl, provided that when A 4 is CR 4, A 5 is CR 5, A 6 is CR 6 and A 8 is CR 8, and each of R 6 and R 8, independently, is H, then R 5 is F, CF 3, CF 2 H, CH 2 F or CH 3; wherein the term "cycloalkyl" denotes a partially or fully saturated ring radical that may contain one, two, or three rings that may be attached together in a fused manner and each formed from carbon atoms. A 4 is CR 4 or N; A 5 is CR 5 or N; A 6 is CR 6 or N; A 8 is CR 8 or N, provided that no more than one of A 4, A 5, A 6 and A 8 is N; R 3 is CH 3, CF 3, CH 2 F or CHF 2; each of R 4, R 5, R 6 and R 8, independently, is H, halo, haloalkyl, haloalkoxyl, C 1-4 -alkyl, CN, OH, OC 1-4 -alkyl, S o C 1-4 -alkyl, NHC 1-4 -alkyl or C C 1-4 -alkyl; R 7 is -NH-R 9, -NH-C(=O)-R 9, -C(=O)NH-R 9, -NH-C(=S)-R 9, -O-R 9 or -S-R 9; R 9 is acetyl, C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl or a fully or partially unsaturated 3-, 4-, 5-, 6- or 7-membered monocyclic or 8-, 9- or 10-membered bicyclic ring formed of carbon atoms, said ring optionally including 1-4 heteroatoms if monocyclic or 1-5 heteroatoms if bicyclic, said heteroatoms selected from O, N or S, wherein the C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl and ring are optionally substituted, independently, with 1-5 substituents of R 10; and each R 10, independently, is H, halo, haloalkyl, CN, OH, NO 2, NH 2, SF 5, acetyl, -C NHCH 3, oxo, cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl, piperazinyl, oxetan-3-yl, imidazo-pyridinyl or dioxolyl, wherein each of the cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetan-3-yl or dioxolyl, is optionally substituted independently with 1-5 substituents of F, Cl, CN, NO 2, NH 2, OH, oxo, CF 3, CHF 2, CH 2 F, methyl, methoxy, ethyl, ethoxy, CH 2 CF 3, CH 2 CHF 2, propyl, propoxy, isopropyl, isopropoxy, cyclopropyl, butyl, butoxyl, cyclobutyl, isobutoxy, tert-butoxy, isobutyl, sec-butyl, tert-butyl, C 1-3 alkylamino-, C 1-3 dialkylamino, C 1-3 thioalkoxyl, oxazolyl, or oxetan-3yl, provided that when A 4 is CR 4, A 5 is CR 5, A 6 is CR 6 and A 8 is CR 8, and each of R 6 and R 8, independently, is H, then R 5 is F, CF 3, CF 2 H, CH 2 F or CH 3; wherein the term "cycloalkyl" denotes a partially or fully saturated ring radical that may contain one, two, or three rings that may be attached together in a fused manner and each formed from carbon atoms.