A compound of Formula, or a pharmaceutically acceptable salt thereof: or a stereoisomer thereof or mixture of stereoisomers thereof, wherein R 8 is H or methyl; R 9 is -H, methyl, or hydroxyl; R 10 is methyl, hydroxyl, or NR 11 R 12; and wherein R 11 and R 12 are independently selected, and wherein R 11 is -H, methyl, or -CH 2 -C CH 2 CH 3; and R 12 is -H, oxopyrrolidinyl, dioxidothiopyranyl, isopropylsulfonyl, tetrahydropyranyl, oxetanyl, tetrahydrofuranyl, hydroxyl, dimethylaminethanesulfonyl, aminethanesulfonyl, dimethylaminpropanesulfonyl, C 1 -C 6 alkyl that is linear, branched, or cyclic, optionally substituted with methoxy, -F, ≡N, methyl oxetanyl, ethoxy, oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or -CF3, acetamidyl optionally substituted with methyl or ethyl, oxazolyl optionally substituted with methyl, pyrazolyl optionally substituted with methyl, cyano, or hydroxyl, -C R 13, wherein R 13 is C 1 to C 7 alkyl that is cyclic, branched, or linear, optionally substituted with NR 15 R 14, wherein R 15 and R 14 are independently selected from methyl and -H; methoxy, hydroxyl, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methyl amino, thiazolyl, -F, morpholinyl, methylisoxazolyl, methyl oxetanyl, aminooxetanyl, phenyl optionally substituted with hydroxyl, -C NH 2; a five membered cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, wherein the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl. R 8 is H or methyl; R 9 is -H, methyl, or hydroxyl; R 10 is methyl, hydroxyl, or NR 11 R 12; and wherein R 11 and R 12 are independently selected, and wherein R 11 is -H, methyl, or -CH 2 -C CH 2 CH 3; and R 12 is -H, oxopyrrolidinyl, dioxidothiopyranyl, isopropylsulfonyl, tetrahydropyranyl, oxetanyl, tetrahydrofuranyl, hydroxyl, dimethylaminethanesulfonyl, aminethanesulfonyl, dimethylaminpropanesulfonyl, C 1 -C 6 alkyl that is linear, branched, or cyclic, optionally substituted with methoxy, -F, ≡N, methyl oxetanyl, ethoxy, oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or -CF3, acetamidyl optionally substituted with methyl or ethyl, oxazolyl optionally substituted with methyl, pyrazolyl optionally substituted with methyl, cyano, or hydroxyl, -C R 13, wherein -H, oxopyrrolidinyl, dioxidothiopyranyl, isopropylsulfonyl, tetrahydropyranyl, oxetanyl, tetrahydrofuranyl, hydroxyl, dimethylaminethanesulfonyl, aminethanesulfonyl, dimethylaminpropanesulfonyl, C 1 -C 6 alkyl that is linear, branched, or cyclic, optionally substituted with methoxy, -F, ≡N, methyl oxetanyl, ethoxy, oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or -CF3, acetamidyl optionally substituted with methyl or ethyl, oxazolyl optionally substituted with methyl, pyrazolyl optionally substituted with methyl, cyano, or hydroxyl, methoxy, -F, ≡N, methyl oxetanyl, ethoxy, oxo-, methyl imidazolyl, methylthio piperazinyl optionally substituted with methyl or -CF3, acetamidyl optionally substituted with methyl or ethyl, oxazolyl optionally substituted with methyl, pyrazolyl optionally substituted with methyl, cyano, or hydroxyl, -C R 13, wherein R 13 is C 1 to C 7 alkyl that is cyclic, branched, or linear, optionally substituted with NR 15 R 14, wherein R 15 and R 14 are independently selected from methyl and -H; methoxy, hydroxyl, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methyl amino, thiazolyl, -F, morpholinyl, methylisoxazolyl, methyl oxetanyl, aminooxetanyl, phenyl optionally substituted with hydroxyl, -C NH 2; a five membered cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, wherein the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl. C 1 to C 7 alkyl that is cyclic, branched, or linear, optionally substituted with NR 15 R 14, wherein R 15 and R 14 are independently selected from methyl and -H; methoxy, hydroxyl, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methyl amino, thiazolyl, -F, morpholinyl, methylisoxazolyl, methyl oxetanyl, aminooxetanyl, phenyl optionally substituted with hydroxyl, -C NH 2; a five membered cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, wherein the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl. NR 15 R 14, wherein R 15 and R 14 are independently selected from methyl and -H; methoxy, hydroxyl, methylthio, ethylthio, methylsulfonyl, oxo-, thiazolidinyl, pyridinyl, pyrazolopyridinyl, methyl amino, thiazolyl, -F, morpholinyl, methylisoxazolyl, methyl oxetanyl, aminooxetanyl, phenyl optionally substituted with hydroxyl, -C NH 2; a five membered cycloalkyl, saturated or unsaturated, in which 1 or 2 carbon atoms are replaced by nitrogen atoms, wherein the cycloamine or cyclodiamine is optionally substituted with hydroxyl or methyl.