mhurhangee/ep-ind-claims huggingface dataset:
A process for preparing a pharmaceutical dosage unit tablet core, the process comprising: blending a particulate pharmaceutical drug active which is cobimetinib hemifumarate polymorph Form A, an intragranular filler comprising lactose or lactose and microcrystalline cellulose, wherein the weight ratio of lactose to microcrystalline cellulose is from about 1:1.5 to about 4:1, an intragranular disintegrant comprising sodium starch glycolate, croscarmellose sodium, and combinations thereof, and an intragranular lubricant comprising magnesium stearate, sodium stearyl fumarate, and combinations thereof, to form a pre-blend, wherein the particulate pharmaceutical drug active has a particle size D[v, 0.5] of from about 25 μm to about 65 μm, from about 25μm to about 50 μm, or from about 30μm to about 40 μm; compacting the pre-blend by application of a compaction force of from about 1 kN/cm to about 8 kN/cm, from about 2 kN/cm to about 5 kN/cm or from about 2 kN/cm to about 4 kN/cm; milling and screening the compacted pre-blend to form granules; and tableting the granules by application of a tableting compression force of from about 5 kN to about 20 kN, from about 14 kN to about 19 kN, from about 14 kN to about 18 kN, or from about 8 kN to about 13 kN to form the pharmaceutical dosage unit tablet core. blending a particulate pharmaceutical drug active which is cobimetinib hemifumarate polymorph Form A, an intragranular filler comprising lactose or lactose and microcrystalline cellulose, wherein the weight ratio of lactose to microcrystalline cellulose is from about 1:1.5 to about 4:1, an intragranular disintegrant comprising sodium starch glycolate, croscarmellose sodium, and combinations thereof, and an intragranular lubricant comprising magnesium stearate, sodium stearyl fumarate, and combinations thereof, to form a pre-blend, wherein the particulate pharmaceutical drug active has a particle size D[v, 0.5] of from about 25 μm to about 65 μm, from about 25μm to about 50 μm, or from about 30μm to about 40 μm; compacting the pre-blend by application of a compaction force of from about 1 kN/cm to about 8 kN/cm, from about 2 kN/cm to about 5 kN/cm or from about 2 kN/cm to about 4 kN/cm; milling and screening the compacted pre-blend to form granules; and tableting the granules by application of a tableting compression force of from about 5 kN to about 20 kN, from about 14 kN to about 19 kN, from about 14 kN to about 18 kN, or from about 8 kN to about 13 kN to form the pharmaceutical dosage unit tablet core.
A calibration device for calibrating an industrial weighing assembly comprising a load-receiving tray and a measuring system, said assembly being arranged such that a free space is provided under said tray, characterized in that the device comprises counter-thrust means for a load arranged on the weighing assembly, the counter-thrust means comprising at least three load thrust cylinders, each being provided with a force sensor, each of the force sensors being connected to an acquisition and processing system in order to establish the load equivalent to the counter-thrust exerted by each of the load thrust cylinders in order to characterize a possible load measurement deviation between the thrust force exerted by the load thrust cylinders and the load measured by the measuring system of the weighing assembly before the load thrust cylinders are pushed.
An ocular implant, comprising: a diffractive multifocal intraocular lens (200, 400) operable to provide a distance, a near and an intermediate focus, the diffractive multifocal IOL having a thin edge operable to support a smaller incision, wherein the diffractive multifocal IOL comprises a central diffractive region (204, 404), a center-distance refractive region and an outer refractive region (206, 406), a plurality of haptics coupled to the diffractive multifocal IOL operable to position the diffractive multifocal IOL within an eye characterised by a phase of the outer refractive region matching the phase of the central diffractive region and the phase of the center-distance refractive region shifted out of phase from the central diffractive region by 1/16 of a wave to phase-shift optical energy such that constructive interference between the center-distance refractive region and the central diffractive region occurs at both the distance and intermediate foci. a diffractive multifocal intraocular lens (200, 400) operable to provide a distance, a near and an intermediate focus, the diffractive multifocal IOL having a thin edge operable to support a smaller incision, wherein the diffractive multifocal IOL comprises a central diffractive region (204, 404), a center-distance refractive region and an outer refractive region (206, 406), a plurality of haptics coupled to the diffractive multifocal IOL operable to position the diffractive multifocal IOL within an eye characterised by a phase of the outer refractive region matching the phase of the central diffractive region and the phase of the center-distance refractive region shifted out of phase from the central diffractive region by 1/16 of a wave to phase-shift optical energy such that constructive interference between the center-distance refractive region and the central diffractive region occurs at both the distance and intermediate foci.
A method for controlling a rear collision traffic assist brake, RCTB, system of a vehicle, comprising: receiving information on an ego vehicle and an obstacle, for predicting a collision with the obstacle in a rear side of the ego vehicle; performing braking by a reference braking pressure that is generated when the collision with the obstacle is predicted; storing a location of the ego vehicle at a reference point in time when the reference braking pressure is generated, a speed of the ego vehicle, an estimated reference collision distance, which is a distance from the ego vehicle to an estimated collision point with the obstacle, and an estimated reference collision time; monitoring whether the braking is performed in a normal braking situation based on the stored data; and generating an additional braking pressure to increase a total braking pressure applied for the braking when it is determined that the braking is performed not in a normal braking situation during the monitoring. receiving information on an ego vehicle and an obstacle, for predicting a collision with the obstacle in a rear side of the ego vehicle; performing braking by a reference braking pressure that is generated when the collision with the obstacle is predicted; storing a location of the ego vehicle at a reference point in time when the reference braking pressure is generated, a speed of the ego vehicle, an estimated reference collision distance, which is a distance from the ego vehicle to an estimated collision point with the obstacle, and an estimated reference collision time; monitoring whether the braking is performed in a normal braking situation based on the stored data; and generating an additional braking pressure to increase a total braking pressure applied for the braking when it is determined that the braking is performed not in a normal braking situation during the monitoring.
A system (1,21) for preventing or limiting control of a lighting device (31-33, 35-37) in a first connected lighting system (41,44), said system (1,21) comprising at least one processor (5,25) configured to: - determine a current or expected state of said lighting device (31-33, 35-37), - determine control permissions characterised in that - said determination of control permissions is based on said current or expected state of said lighting device (31-33, 35-37), and - said at least one processor (5, 25) is further configured to prevent or limit control of said lighting device (31-33, 35-37) by a second connected lighting system (42,45) located in a same building as said first connected lighting system (41,44) in dependence on said control permissions. - determine a current or expected state of said lighting device (31-33, 35-37), - determine control permissions - said determination of control permissions is based on said current or expected state of said lighting device (31-33, 35-37), and - said at least one processor (5, 25) is further configured to
A guidewire comprising: a corewire having a proximal end portion and a distal end portion; an elongate shroud disposed about said corewire, said shroud having a distal end; a plug coupled with said distal end portion of said corewire and said distal end of said shroud, said plug having a distal, non-traumatic tip portion, an interior between said corewire and said shroud being configured to receive a sensor; and a sensor disposed in said interior, characterized in that said sensor comprises: a core comprising magnetically permeable material and having an axis, said core having a lumen axially extending therethrough, said corewire extending through said lumen; and a coil disposed about said core. a corewire having a proximal end portion and a distal end portion; an elongate shroud disposed about said corewire, said shroud having a distal end; a plug coupled with said distal end portion of said corewire and said distal end of said shroud, said plug having a distal, non-traumatic tip portion, an interior between said corewire and said shroud being configured to receive a sensor; and a sensor disposed in said interior, characterized in that said sensor comprises: a core comprising magnetically permeable material and having an axis, said core having a lumen axially extending therethrough, said corewire extending through said lumen; and a coil disposed about said core. a core comprising magnetically permeable material and having an axis, said core having a lumen axially extending therethrough, said corewire extending through said lumen; and a coil disposed about said core.
Method for filtering a response signal of a geophone, said geophone including a magnet surrounded by a coil mounted so as to be able to move with respect to the magnet, the coil being able to move following vibrations of an environment of said coil, the geophone having an intrinsic damping (m) and an intrinsic natural frequency (f 0), said method including: - determining the intrinsic damping (m) and the intrinsic natural frequency (f 0) of the geophone, comprising: ∘ supplying the coil with an excitation current for a predetermined period, ∘ determining, by means of the response signal of the geophone measured when the excitation current disappears, said signal representing the current induced in the coil by the movement of the coil with respect to the magnet, the intrinsic natural frequency and the intrinsic damping of the geophone, - determining a digital filter configured for modifying a natural frequency of the geophone from an intrinsic natural frequency (f 0) to a set natural frequency (f 1), the set natural frequency (f 1) being lower than the intrinsic natural frequency (fo), and adjusting the gain of the geophone so that said gain is substantially constant for frequencies lying between the set natural frequency (f 1) and the intrinsic natural frequency, - applying said filter to said response signal of the geophone. - determining the intrinsic damping (m) and the intrinsic natural frequency (f 0) of the geophone, comprising: ∘ supplying the coil with an excitation current for a predetermined period, ∘ determining, by means of the response signal of the geophone measured when the excitation current disappears, said signal representing the current induced in the coil by the movement of the coil with respect to the magnet, the intrinsic natural frequency and the intrinsic damping of the geophone, ∘ supplying the coil with an excitation current for a predetermined period, ∘ determining, by means of the response signal of the geophone measured when the excitation current disappears, said signal representing the current induced in the coil by the movement of the coil with respect to the magnet, the intrinsic natural frequency and the intrinsic damping of the geophone, - determining a digital filter configured for modifying a natural frequency of the geophone from an intrinsic natural frequency (f 0) to a set natural frequency (f 1), the set natural frequency (f 1) being lower than the intrinsic natural frequency (fo), and adjusting the gain of the geophone so that said gain is substantially constant for frequencies lying between the set natural frequency (f 1) and the intrinsic natural frequency, - applying said filter to said response signal of the geophone.
A dental curing light for curing a dental composite within a tooth, the dental curing light comprising: a light source adapted to direct light onto the dental composite within the tooth; a vision system adapted to acquire an image of the dental composite within the tooth, the vision system including a multi-planar mirror, and the image including multiple image portions acquired from different angles using the multi-planar mirror; and a control system operatively coupled to the light source and to the vision system, the control system adapted to determine the distance between the light source and the dental composite as a function of the multiple image portions, the control system further adapted to control the light source as a function of the determined distance. a light source adapted to direct light onto the dental composite within the tooth; a vision system adapted to acquire an image of the dental composite within the tooth, the vision system including a multi-planar mirror, and the image including multiple image portions acquired from different angles using the multi-planar mirror; and a control system operatively coupled to the light source and to the vision system, the control system adapted to determine the distance between the light source and the dental composite as a function of the multiple image portions, the control system further adapted to control the light source as a function of the determined distance.
Automatic load-lifting fixture intended for attachment to a lifting machine or device and to be attached to a load to be lifted constituted by a prism-shaped genera frame, at one end of which is removably mounted a transversal shaft having fixed to one end an eyebolt linked to a shackle for attachment to the relevant lifting machine, while the other end of said shaft features a triangular cross-piece to be attached to the load, wherein the shaft is rotated and operated automatically by electro-pneumatic or electro-hydraulic means so that it can be placed in open, closed or in intermediate positions, and wherein the automatic load-lifting fixture can be actuated manually as well as by remote control.
Non-degerminated cereal mash and/or pseudocereal mash, characterized in that the mash is aerated, has been inoculated with at least one species from the group of acetic acid bacteria consisting of Gluconobacter, Gluconacetobacter, Acidomonas, Kozakia, Neoasaia, Asaia, Swaminathania, Saccharibacter and Frateuria, and the mash contains metabolic products, namely acetic acid, gluconic acid and exopolysaccharides formed by at least one species from the group of acetic acid bacteria consisting of Gluconobacter, Gluconacetobacter, Acidomonas, Kozakia, Neoasaia, Asaia, Swaminathania, Saccharibacter and Frateuria, said metabolic products having been formed from an added proportion of 1.5 - 10% saccharose relative to the employed amount of flour in the mash, and the mash having a concentration of the acetic acid bacteria with a live germ count of 10e8 per ml.
A nitride-based, red-emitting phosphor having the formula M m A a B b (N,D) n:Z z, where: M is at least one divalent metal; A is a trivalent metal or semimetal; B is a tetravalent metal or semimetal; N is nitrogen; Z is an activator in the host crystal; D is a halogen selected from the group consisting of F, Cl and Br in an amount ranging from about 0.2 to 5 atomic percent; and wherein the stoichiometric ratios of the constituent elements (m+z):a:b:n are about 1:1:1:2.5-3.5. M is at least one divalent metal; A is a trivalent metal or semimetal; B is a tetravalent metal or semimetal; N is nitrogen; Z is an activator in the host crystal; D is a halogen selected from the group consisting of F, Cl and Br in an amount ranging from about 0.2 to 5 atomic percent; and wherein the stoichiometric ratios of the constituent elements (m+z):a:b:n are about 1:1:1:2.5-3.5.
A method for compensating the influence of at least one of the parameters from the group consisting of flow rate, viscosity, density and Reynolds number (Re) of a fluid to be measured, on the measured flow rate and/or density of this fluid in a Coriolis mass flow meter, characterized by determining a compensation value (Mf(Re)) for the flow rate and/or density of the fluid to be measured using the following equation M f Re = f max 2 ⋅ 1 − tanh − 2 f max ⋅ dM f d log 10 Re | Re = Re c ⋅ log 10 Re − log 10 Re c, where f max is the maximum compensation value (Mf(Re)) for Reynolds numbers (Re) approaching zero, Re c is the Reynolds number (Re) at which the curve of the compensation value (Mf(Re)) has the largest slope, and dM f d log 10 Re | Re = Re c is the slope of the curve of the compensation value (Mf(Re)) at the point Re c, and correcting the value measured by the Coriolis mass flow meter for the flow rate and/or the density of the fluid to be measured using the compensation value (M f (Re)).
A method for producing a nucleic acid sample by recovering nucleic acid from cells, comprising the steps of with respect to a cell sample containing cells, releasing nucleic acid complexes from the cells, wherein the cell sample is mixed with a treatment reagent containing a protease and a surfactant in an aqueous solvent to generate a treatment liquid and wherein said nucleic acid complexes have a diameter of 50 to 200μm; contacting the treatment liquid containing the cell sample from step with a carrier in a container, wherein said carrier is capable of capturing said released nucleic acid complexes and the carrier is at least one selected from the group consisting of nonwoven fabric, woven fabric, porous bodies and a bead; separating the carrier from the treatment liquid, wherein the carrier is separated from the treatment liquid by taking the carrier or the treatment liquid out of the container; applying heat treatment to the carrier at 90°C to 100 °C for 1 minute to 5 minutes; and adding a dispersion medium which is an aqueous solvent to the carrier before or after step, wherein a nucleic acid-insoluble organic solvent is not used in said method. with respect to a cell sample containing cells, releasing nucleic acid complexes from the cells, wherein the cell sample is mixed with a treatment reagent containing a protease and a surfactant in an aqueous solvent to generate a treatment liquid and wherein said nucleic acid complexes have a diameter of 50 to 200μm; contacting the treatment liquid containing the cell sample from step with a carrier in a container, wherein said carrier is capable of capturing said released nucleic acid complexes and the carrier is at least one selected from the group consisting of nonwoven fabric, woven fabric, porous bodies and a bead; separating the carrier from the treatment liquid, wherein the carrier is separated from the treatment liquid by taking the carrier or the treatment liquid out of the container; applying heat treatment to the carrier at 90°C to 100 °C for 1 minute to 5 minutes; and adding a dispersion medium which is an aqueous solvent to the carrier before or after step,
Cooling device comprising a heat pipe of which the evaporation and condensation parts are located respectively in a hot zone and a cold zone, said heat pipe being intended to discharge the heat from the hot zone to the cold zone, characterized in that the evaporation part of the heat pipe (6, 60, 61, 63) is linked to a voltage regulator belonging to a rotating electric machine, such as an alternator or an alternator-starter, comprising a housing provided with a front bearing and a rear bearing, one of these bearings bearing at least one current rectifying device comprising a positive dissipater bearing rectifying elements, such as diodes or transistors of the MOSFET type and in that the condensation part of the heat pipe is linked to one of the bearings forming a cold source.
Method for connecting a terminal into a region, assigned to a user, of a networkable computer infrastructure which is configured for a plurality of users (6, 6a), wherein a user certificate is created for the region assigned to the user and is made available to the user and/or to the networkable computer infrastructure, wherein a terminal certificate compatible with the user certificate is created, wherein the terminal certificate is created on the basis of the user certificate - by the user and/or - within that region of the networkable computer infrastructure which is assigned to the user by means of an appropriate application, wherein the terminal certificate is input to the terminal, wherein the terminal is registered in the networkable computer infrastructure via a data connection, wherein, for the registration, the terminal certificate and/or a password encrypted on the basis of the terminal certificate is/are transmitted from the terminal to the networkable computer infrastructure via the data connection, wherein the terminal is authenticated in the networkable computer infrastructure on the basis of a check of compatibility of the transmitted terminal certificate and/or the transmitted password encrypted on the basis of the terminal certificate with the user certificate, and wherein, in the event of successful authentication, use of the networkable computer infrastructure in the region assigned to the user is enabled for the terminal. wherein a user certificate is created for the region assigned to the user and is made available to the user and/or to the networkable computer infrastructure, wherein a terminal certificate compatible with the user certificate is created, wherein the terminal certificate is created on the basis of the user certificate - by the user and/or - within that region of the networkable computer infrastructure which is assigned to the user by means of an appropriate application, - by the user and/or - within that region of the networkable computer infrastructure which is assigned to the user by means of an appropriate application, wherein the terminal certificate is input to the terminal, wherein the terminal is registered in the networkable computer infrastructure via a data connection, wherein, for the registration, the terminal certificate and/or a password encrypted on the basis of the terminal certificate is/are transmitted from the terminal to the networkable computer infrastructure via the data connection, wherein the terminal is authenticated in the networkable computer infrastructure on the basis of a check of compatibility of the transmitted terminal certificate and/or the transmitted password encrypted on the basis of the terminal certificate with the user certificate, and wherein, in the event of successful authentication, use of the networkable computer infrastructure in the region assigned to the user is enabled for the terminal.