A compound of formula: wherein R is: either a linear or branched C 1 -C 6 alkyl group, substituted with one or more substituents independently selected from NR 3 R 4, OC 1 -C 6 alkyl and CO 2 C 1 -C 6 alkyl; or substituted with piperidinyl, which is further substituted with a R 9 -C 1 -C 6 alkyl group; or a piperidinyl group, further substituted with a C 5 -C 6 cycloalkyl group, further substituted with one or more substituents independently selected from halogen atom, NR 3 R 4, oxo (=O), OR 5, and an optionally substituted linear or branched C 1 -C 6 alkyl group; when simultaneously present, two substituents such as NR 3 R 4 and OR5, may form, taken together, an optionally substituted heterocyclyl group; R 1 is hydrogen or halogen atom; R 3 and R 4 are independently hydrogen atom or an optionally further substituted linear or branched C 1 -C 6 alkyl; R 5 is hydrogen atom, or an optionally further substituted linear or branched C 1 -C 6 alkyl; Rg is an aryl or heteroaryl group, further substituted with one or more substituents independently selected from halogen atom and linear or branched C 1 -C 6 alkyl; with the proviso that the compound 1H-isoindole-4-carboxamide, 2,3-dihydro-2-(3-methoxypropyl)-3-oxo is excluded, or a pharmaceutically acceptable salt thereof. R is: either a linear or branched C 1 -C 6 alkyl group, substituted with one or more substituents independently selected from NR 3 R 4, OC 1 -C 6 alkyl and CO 2 C 1 -C 6 alkyl; or substituted with piperidinyl, which is further substituted with a R 9 -C 1 -C 6 alkyl group; or a piperidinyl group, further substituted with a C 5 -C 6 cycloalkyl group, further substituted with one or more substituents independently selected from halogen atom, NR 3 R 4, oxo (=O), OR 5, and an optionally substituted linear or branched C 1 -C 6 alkyl group; when simultaneously present, two substituents such as NR 3 R 4 and OR5, may form, taken together, an optionally substituted heterocyclyl group; either a linear or branched C 1 -C 6 alkyl group, substituted with one or more substituents independently selected from NR 3 R 4, OC 1 -C 6 alkyl and CO 2 C 1 -C 6 alkyl; or substituted with piperidinyl, which is further substituted with a R 9 -C 1 -C 6 alkyl group; or a piperidinyl group, further substituted with a C 5 -C 6 cycloalkyl group, further substituted with one or more substituents independently selected from halogen atom, NR 3 R 4, oxo (=O), OR 5, and an optionally substituted linear or branched C 1 -C 6 alkyl group; when simultaneously present, two substituents such as NR 3 R 4 and OR5, may form, taken together, an optionally substituted heterocyclyl group; further substituted with a C 5 -C 6 cycloalkyl group, further substituted with one or more substituents independently selected from halogen atom, NR 3 R 4, oxo (=O), OR 5, and an optionally substituted linear or branched C 1 -C 6 alkyl group; when simultaneously present, two substituents such as NR 3 R 4 and OR5, may form, taken together, an optionally substituted heterocyclyl group; R 1 is hydrogen or halogen atom; R 3 and R 4 are independently hydrogen atom or an optionally further substituted linear or branched C 1 -C 6 alkyl; R 5 is hydrogen atom, or an optionally further substituted linear or branched C 1 -C 6 alkyl; Rg is an aryl or heteroaryl group, further substituted with one or more substituents independently selected from halogen atom and linear or branched C 1 -C 6 alkyl; with the proviso that the compound 1H-isoindole-4-carboxamide, 2,3-dihydro-2-(3-methoxypropyl)-3-oxo is excluded,