A tissue disruption system comprising: a rigid conduit having an open proximal end, a distal opening and a direction of elongation, and; a tissue disruption device for deployment via said conduit, the tissue disruption device comprising: (a) a rotary tissue disruptor having an axis of rotation, said rotary tissue disruptor being configured for insertion along the rigid conduit with said axis of rotation parallel to the direction of elongation; (b) an elongated member deployable so as to extend through said conduit and linked so as to support said rotary tissue disruptor during insertion of said rotary tissue disruptor along said conduit; (c) an angular displacement mechanism (22, 32, 34, 38, 44) associated with said rotary tissue disruptor and configured to selectively displace said rotary tissue disruptor such that said axis of rotation sweeps through a range of angular motion; and (d) a rotary drive linked to said rotary tissue disruptor so as to drive said rotary tissue disruptor in rotary motion while said rotary tissue disruptor is at a range of angular positions within said range of angular motion, characterised in that said tissue disruption device mechanically interacts with said conduit such that linear displacement of said rotary tissue disruptor parallel to said direction of elongation is prevented or is limited to a predefined range of displacement during said angular motion. a rigid conduit having an open proximal end, a distal opening and a direction of elongation, and; a tissue disruption device for deployment via said conduit, the tissue disruption device comprising: (a) a rotary tissue disruptor having an axis of rotation, said rotary tissue disruptor being configured for insertion along the rigid conduit with said axis of rotation parallel to the direction of elongation; (b) an elongated member deployable so as to extend through said conduit and linked so as to support said rotary tissue disruptor during insertion of said rotary tissue disruptor along said conduit; (c) an angular displacement mechanism (22, 32, 34, 38, 44) associated with said rotary tissue disruptor and configured to selectively displace said rotary tissue disruptor such that said axis of rotation sweeps through a range of angular motion; and (d) a rotary drive linked to said rotary tissue disruptor so as to drive said rotary tissue disruptor in rotary motion while said rotary tissue disruptor is at a range of angular positions within said range of angular motion, characterised in that said tissue disruption device mechanically interacts with said conduit such that linear displacement of said rotary tissue disruptor parallel to said direction of elongation is prevented or is limited to a predefined range of displacement during said angular motion. (a) a rotary tissue disruptor having an axis of rotation, said rotary tissue disruptor being configured for insertion along the rigid conduit with said axis of rotation parallel to the direction of elongation; (b) an elongated member deployable so as to extend through said conduit and linked so as to support said rotary tissue disruptor during insertion of said rotary tissue disruptor along said conduit; (c) an angular displacement mechanism (22, 32, 34, 38, 44) associated with said rotary tissue disruptor and configured to selectively displace said rotary tissue disruptor such that said axis of rotation sweeps through a range of angular motion; and (d) a rotary drive linked to said rotary tissue disruptor so as to drive said rotary tissue disruptor in rotary motion while said rotary tissue disruptor is at a range of angular positions within said range of angular motion, characterised in that said tissue disruption device mechanically interacts with said conduit such that linear displacement of said rotary tissue disruptor parallel to said direction of elongation is prevented or is limited to a predefined range of displacement during said angular motion.