A compound represented by Formula I-A: or a pharmaceutically acceptable salt thereof; wherein: A 1 is phenylene or a 5-6 membered heteroarylene; X is phenyl or 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, halogen, C 1-6 haloalkyl, hydroxyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -O-C 3-6 cycloalkyl, -O-(C 1-6 alkylene)-OH, cyano, -N(R 4)(R 5), and C 6-10 aryl; R 1 represents independently for each occurrence halogen, C 1-6 alkyl, or C 1-6 haloalkyl; R 2A is -(C 1-6 alkylene)-A 2, -(C 3-6 cycloalkylene)-A 2, -(2-6 membered heteroalkylene)-A 2, or -CO 2 R 4; wherein A 2 is -CO 2 R 4, -C -A 3, -C N(R 4)(R 5), -C N(R 4)-(C 1-4 alkylene)-CO 2 R 4, - N(R 4)C R 7, -N(R 4)C A 3, -N(R 4)C -(C 1-6 alkylene)-CO 2 R 4, -N(R 4)C N(R 4)-(C 1-6 alkylene)-CO 2 R 4, -N(R 4)CO 2 R 6, or A 3; and A 3 is a 5-8 membered heterocyclic group optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, halogen, C 1-6 alkoxy, C 1-6 haloalkoxy, oxo, -C R 6, and -CO 2 R 7; R 2B represents independently for each occurrence C 1-6 alkyl or C 1-3 haloalkyl; R 3 represents independently for each occurrence hydrogen, C 1-6 haloalkyl, halogen, hydroxyl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1 - 6 haloalkoxy, -O-(C 1-6 alkylene)-OH, or -O-(C 1-6 alkylene)-CO 2 R 4; R 4 and R 5 each represent independently for each occurrence hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; or an occurrence of R 4 and R 5 attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached to form a 3-7 membered heterocyclic ring; R 6 represents independently for each occurrence C 1-6 alkyl, C 3-6 cycloalkyl, or aralkyl; R 7 represents independently for each occurrence hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-6 cycloalkyl, C 3-6 hydroxycycloalkyl, or aralkyl; m and p are independently 0, 1, or 2; and n is 1, 2, or 3. A 1 is phenylene or a 5-6 membered heteroarylene; X is phenyl or 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, halogen, C 1-6 haloalkyl, hydroxyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -O-C 3-6 cycloalkyl, -O-(C 1-6 alkylene)-OH, cyano, -N(R 4)(R 5), and C 6-10 aryl; R 1 represents independently for each occurrence halogen, C 1-6 alkyl, or C 1-6 haloalkyl; R 2A is -(C 1-6 alkylene)-A 2, -(C 3-6 cycloalkylene)-A 2, -(2-6 membered heteroalkylene)-A 2, or -CO 2 R 4; wherein A 2 is -CO 2 R 4, -C -A 3, -C N(R 4)(R 5), -C N(R 4)-(C 1-4 alkylene)-CO 2 R 4, - N(R 4)C R 7, -N(R 4)C A 3, -N(R 4)C -(C 1-6 alkylene)-CO 2 R 4, -N(R 4)C N(R 4)-(C 1-6 alkylene)-CO 2 R 4, -N(R 4)CO 2 R 6, or A 3; and A 3 is a 5-8 membered heterocyclic group optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, halogen, C 1-6 alkoxy, C 1-6 haloalkoxy, oxo, -C R 6, and -CO 2 R 7; R 2B represents independently for each occurrence C 1-6 alkyl or C 1-3 haloalkyl; R 3 represents independently for each occurrence hydrogen, C 1-6 haloalkyl, halogen, hydroxyl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1 - 6 haloalkoxy, -O-(C 1-6 alkylene)-OH, or -O-(C 1-6 alkylene)-CO 2 R 4; R 4 and R 5 each represent independently for each occurrence hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; or an occurrence of R 4 and R 5 attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached to form a 3-7 membered heterocyclic ring; R 6 represents independently for each occurrence C 1-6 alkyl, C 3-6 cycloalkyl, or aralkyl; R 7 represents independently for each occurrence hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-6 cycloalkyl, C 3-6 hydroxycycloalkyl, or aralkyl; m and p are independently 0, 1, or 2; and n is 1, 2, or 3.