A system comprising: a first aseptic coupling device comprising an inner member defining a first fluid passage therethrough, a first seal member coupled to a front surface of the inner member, a first membrane coupled to the front surface of the inner member to cover the first seal member, a clip, and a locking ring positioned to rotate about the inner member; and a second aseptic coupling device comprising a main body defining a second fluid passage therethrough, a front portion coupled to the main body, the front portion defining a plurality of channels therein, a second seal member coupled to a front surface of the main body, a second membrane coupled to the front surface of the main body to cover the second seal member, and a slot defined in the main body sized to receive the clip, wherein the inner member is sized to be received in the front portion of the second aseptic coupling device to form a pre-coupled state in which the first aseptic coupling device is connected to the second aseptic coupling device but a sterile flow path has not yet been created because the first membrane and the second membrane are not yet removed, wherein, when the first membrane and the second membrane are removed, the first seal member engages the second seal member of the second aseptic device, and wherein, upon turning of the locking ring, barbs of the locking ring are received within the channels of the front portion to compress the first seal member and the second seal member to form a coupled state in which a sterile flow path is created between the first aseptic device and the second aseptic device, wherein the front portion is sized to receive the inner member of the first aseptic coupling device so that the clip engages the first aseptic coupling device to form the pre-coupled state. a first aseptic coupling device comprising an inner member defining a first fluid passage therethrough, a first seal member coupled to a front surface of the inner member, a first membrane coupled to the front surface of the inner member to cover the first seal member, a clip, and a locking ring positioned to rotate about the inner member; and an inner member defining a first fluid passage therethrough, a first seal member coupled to a front surface of the inner member, a first membrane coupled to the front surface of the inner member to cover the first seal member, a clip, and a locking ring positioned to rotate about the inner member; and a second aseptic coupling device comprising a main body defining a second fluid passage therethrough, a front portion coupled to the main body, the front portion defining a plurality of channels therein, a second seal member coupled to a front surface of the main body, a second membrane coupled to the front surface of the main body to cover the second seal member, and a slot defined in the main body sized to receive the clip, a main body defining a second fluid passage therethrough, a front portion coupled to the main body, the front portion defining a plurality of channels therein, a second seal member coupled to a front surface of the main body, a second membrane coupled to the front surface of the main body to cover the second seal member, and a slot defined in the main body sized to receive the clip, wherein the inner member is sized to be received in the front portion of the second aseptic coupling device to form a pre-coupled state in which the first aseptic coupling device is connected to the second aseptic coupling device but a sterile flow path has not yet been created because the first membrane and the second membrane are not yet removed, wherein, when the first membrane and the second membrane are removed, the first seal member engages the second seal member of the second aseptic device, and wherein, upon turning of the locking ring, barbs of the locking ring are received within the channels of the front portion to compress the first seal member and the second seal member to form a coupled state in which a sterile flow path is created between the first aseptic device and the second aseptic device, wherein the front portion is sized to receive the inner member of the first aseptic coupling device so that the clip engages the first aseptic coupling device to form the pre-coupled state.