A system comprising: a sensing module configured to sense a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; a memory configured to store the sense electrode combinations and associated stimulation electrode combinations, wherein the simulation electrode combinations comprise at least one electrode for delivering electrical stimulation to the brain of the patient; and a processor configured to: select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site, access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, and select, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, an associated stimulation electrode combination; wherein the stimulation electrode combination is associated with the selected sense electrodes in memory; wherein the physiological model indicates one or more anatomical structures of the brain of the patient proximate the at least one electrode within the brain of the patient, or wherein the physiological model comprises a therapy field model that indicates where stimulation will propagate from electrodes of the stimulation electrode combination; and wherein the processor is configured to select the stimulation electrode combination by at least: selecting the stimulation electrode combination based on the selected sense electrode combination, confirming the stimulation electrode combination based on the model. a sensing module configured to sense a plurality of bioelectrical signals in a brain of a patient with respective sense electrode combinations that each comprise at least one electrode; a memory configured to store the sense electrode combinations and associated stimulation electrode combinations, wherein the simulation electrode combinations comprise at least one electrode for delivering electrical stimulation to the brain of the patient; and a processor configured to: select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site, access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, and select, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, an associated stimulation electrode combination; wherein the stimulation electrode combination is associated with the selected sense electrodes in memory; select one of the sense electrode combinations based on a signal characteristic of each of the sensed bioelectrical signals, the signal characteristic indicating a location of the at least one electrode of the respective sense electrode combination relative to a target tissue site, access a physiological model that indicates one or more characteristics of tissue proximate the at least one electrode within the brain of the patient, and select, based on the signal characteristic of the bioelectrical signal sensed with the selected sense electrode combination and the physiological model, an associated stimulation electrode combination; wherein the stimulation electrode combination is associated with the selected sense electrodes in memory; wherein the physiological model indicates one or more anatomical structures of the brain of the patient proximate the at least one electrode within the brain of the patient, or wherein the physiological model comprises a therapy field model that indicates where stimulation will propagate from electrodes of the stimulation electrode combination; and wherein the processor is configured to select the stimulation electrode combination by at least: selecting the stimulation electrode combination based on the selected sense electrode combination, confirming the stimulation electrode combination based on the model. selecting the stimulation electrode combination based on the selected sense electrode combination, confirming the stimulation electrode combination based on the model.