A portable sterilization device (100, 200) for use with one or more sterilants, the portable sterilization device (100, 200) comprising: an external housing unit; a sealable sterilization chamber (110, 210, 310) located within the external housing unit; a sterilant delivery device (180, 280) operatively associated with the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280) comprising a nebulization element, wherein the nebulization element is configured to receive and convert the one or more sterilants into an oxidative aerosol sterilant and is further configured to deliver the oxidative aerosol sterilant into the sealable sterilization chamber (110, 210, 310); an ozone delivery device operatively associated with the sealable sterilization chamber (110, 210, 310) and the sterilant delivery device (180, 280), the ozone delivery device configured to deliver ozone into the sealable sterilization chamber (110, 210, 310); an airflow circulation assembly; a control panel configured to operate the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280), the ozone delivery device, and the airflow circulation assembly; and a power source operatively associated with the control panel and configured to supply power to the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280), the ozone delivery device, and the airflow circulation assembly; whereupon activation, the control panel is configured to execute an operation to provide simultaneous delivery of the oxidative aerosol sterilant and the ozone into the sealable sterilization chamber (110, 210, 310). an external housing unit; a sealable sterilization chamber (110, 210, 310) located within the external housing unit; a sterilant delivery device (180, 280) operatively associated with the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280) comprising a nebulization element, wherein the nebulization element is configured to receive and convert the one or more sterilants into an oxidative aerosol sterilant and is further configured to deliver the oxidative aerosol sterilant into the sealable sterilization chamber (110, 210, 310); an ozone delivery device operatively associated with the sealable sterilization chamber (110, 210, 310) and the sterilant delivery device (180, 280), the ozone delivery device configured to deliver ozone into the sealable sterilization chamber (110, 210, 310); an airflow circulation assembly; a control panel configured to operate the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280), the ozone delivery device, and the airflow circulation assembly; and a power source operatively associated with the control panel and configured to supply power to the sealable sterilization chamber (110, 210, 310), the sterilant delivery device (180, 280), the ozone delivery device, and the airflow circulation assembly; whereupon activation, the control panel is configured to execute an operation to provide simultaneous delivery of the oxidative aerosol sterilant and the ozone into the sealable sterilization chamber (110, 210, 310).