A compound of Formula (VIII): Q-linker-lipid (VIII), wherein: Q is (i) wherein: X is NH or N(CH 2 COO -); and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (ii) wherein: X is S +, C, S + =O, N + H or P=O; X 1 is-CH, -CH 2 or -CH 2 O; X 2 is C=O; and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (iii) wherein: X 1 is (CH 2) n; X 2 is C=O; Z is a platinum containing compound, wherein the platinum forms a part of the ring; and n is 0, 1, or 2; (iv) wherein: R 1, R 2 and R 3 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or a combination thereof; or R 1 and R 2 together with the Pt atom or R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or R 1 and R 2 together with the Pt atom and R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or (v) wherein: R 1, R 2, R 3, R 4 and R 5 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or any combinations thereof; or R 1 and R 2 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl or R 3 and R 4 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; the linker is ethylenediamine, ethylene glycol, glycine, beta-alanine, or polyethylene glycol of molecular weight about 44 to about 200 kD; and the lipid is cholesterol, cholesterol chloroformate, or alpha tocopherol. Q is (i) wherein: X is NH or N(CH 2 COO -); and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (ii) wherein: X is S +, C, S + =O, N + H or P=O; X 1 is-CH, -CH 2 or -CH 2 O; X 2 is C=O; and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (iii) wherein: X 1 is (CH 2) n; X 2 is C=O; Z is a platinum containing compound, wherein the platinum forms a part of the ring; and n is 0, 1, or 2; (iv) wherein: R 1, R 2 and R 3 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or a combination thereof; or R 1 and R 2 together with the Pt atom or R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or R 1 and R 2 together with the Pt atom and R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or (v) wherein: R 1, R 2, R 3, R 4 and R 5 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or any combinations thereof; or R 1 and R 2 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl or R 3 and R 4 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; (i) wherein: X is NH or N(CH 2 COO -); and Z is a platinum containing compound, wherein the platinum forms a part of the ring; X is NH or N(CH 2 COO -); and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (ii) wherein: X is S +, C, S + =O, N + H or P=O; X 1 is-CH, -CH 2 or -CH 2 O; X 2 is C=O; and Z is a platinum containing compound, wherein the platinum forms a part of the ring; X is S +, C, S + =O, N + H or P=O; X 1 is-CH, -CH 2 or -CH 2 O; X 2 is C=O; and Z is a platinum containing compound, wherein the platinum forms a part of the ring; (iii) wherein: X 1 is (CH 2) n; X 2 is C=O; Z is a platinum containing compound, wherein the platinum forms a part of the ring; and n is 0, 1, or 2; X 1 is (CH 2) n; X 2 is C=O; Z is a platinum containing compound, wherein the platinum forms a part of the ring; and n is 0, 1, or 2; (iv) wherein: R 1, R 2 and R 3 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or a combination thereof; or R 1 and R 2 together with the Pt atom or R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or R 1 and R 2 together with the Pt atom and R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or R 1, R 2 and R 3 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or a combination thereof; or R 1 and R 2 together with the Pt atom or R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or R 1 and R 2 together with the Pt atom and R 2 and R 3 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or (v) wherein: R 1, R 2, R 3, R 4 and R 5 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or any combinations thereof; or R 1 and R 2 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl or R 3 and R 4 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; R 1, R 2, R 3, R 4 and R 5 are independently halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, —linker-lipid, or any combinations thereof; or R 1 and R 2 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl or R 3 and R 4 together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; the linker is ethylenediamine, ethylene glycol, glycine, beta-alanine, or polyethylene glycol of molecular weight about 44 to about 200 kD; and the lipid is cholesterol, cholesterol chloroformate, or alpha tocopherol.