Tread profile of a pneumatic vehicle tyre with at least one groove, which is axially delimited by two radially raised ribs (2, 3) that are made to extend over the circumference of the tyre, is itself made to extend over the circumference of the tyre and aligned in the circumferential direction U, is formed with a maximum groove depth T and is delimited in the radial direction R inwardly by a groove base and in both axial directions of extent respectively by a groove wall, which in each case forms a rib flank (5, 6) of one of the two ribs (2, 3) that is directed towards the groove, wherein the two groove walls respectively extend from the groove base radially outwards up to the lateral surface that radially outwardly delimits the respective rib flank (5, 6) and have in each case a radially inner region of extent (8, 10) and a radially outer region of extent (7, 9), of which the radially inner region of extent (8, 10) is formed with a height of extent h in the radial direction from the groove base with (0.07T) ≤ h ≤ (0.45T), the rib flanks (5, 6) in the radially inner region of extent (8, 10) forming in all of the sectional planes that contain the tyre axis either in each case a straight sectional contour with an angle of inclination (γ, δ) in relation to the radial R or a curved contour with a radius of curvature (R k) and a centre point of curvature lying on the side of the rib flank that is facing away from the tyre axis, wherein the groove is formed by first and second circumferential portions that alternate in their sequence along their circumferential extent, each rib flank (5, 6) being formed in its radially inner region of extent (8, 10) in the first circumferential portion with a different inclination or with a different curvature than in the second circumferential portion, to be precise in such a way that the one rib flank respectively has greater angles of inclination γ or a greater radius of curvature (R k) in the first circumferential portions than in the second circumferential portion and the other rib flank respectively has smaller angles of inclination δ or a smaller radius of curvature (R k) in the first circumferential portions than in the second circumferential portion, characterized in that the radially outer region of extent of the first rib flank has in all of the sectional planes having the tyre axis a substantially straight sectional contour with angles of inclination α in relation to the radial R and the radially outer region of extent of the second rib flank has in all of the sectional planes having the tyre axis a substantially straight sectional contour with angles of inclination β in relation to the radial R, wherein the radially outer region of extent of the first rib flank is formed in the first circumferential portions of the groove with angles of inclination α 1 in relation to the radial R and in the second circumferential portions of the groove with angles of inclination α 2 in relation to the radial R, and wherein the radially outer region of extent of the second rib flank is formed in the first circumferential portions of the groove with angles of inclination p 1 in relation to the radial R and in the second circumferential portions of the groove with angles of inclination β 2 in relation to the radial R, with α 1 < α 2 and with β 1 > β 2.