mhurhangee/ep-ind-claims huggingface dataset:
Method for controlling the drying process of hides, or similar products, in the tanning industry, wherein in a drying environment a plurality of support means each suitable for receiving one or more hides, having a known moisture content, are provided, said method being characterized in that, through weight sensors associated with one or more of said support means, the weight of said hides is substantially continuously detected, the detected weight values being substantially continuously transmitted to a control unit which, depending thereon and on the value of said known moisture content of said hides, substantially continuously calculates the instantaneous moisture value of said hides during the drying process and based thereon automatically controls at least one of the following working parameters: the temperature of the air in the drying environment, the relative humidity of the air in the drying environment, the drying time, the speed of an air flow over the surface of said hides in said drying environment.
A computer-implemented method for determining whether or not a subject is likely to respond to a checkpoint blockade therapy, the method comprising: accessing expression data for the subject; using the expression data to determine expression levels, in the subject, for at least three genes; and determining, using the determined expression levels and a statistical model trained using expression data indicating expression levels for a plurality of genes for a plurality of subjects, whether or not the subject is likely to respond to the checkpoint blockade therapy, wherein the checkpoint blockade therapy is a PD1 inhibitor and/or a CTLA4 inhibitor; characterized in that the at least three genes are selected from the set of predictor genes consisting of BRAF, ACVR1B, MPRIP, PRKAG1, STX2, AGPAT3, FYN, CMIP, ROBO4, RAB40C, HAUS8, SNAP23, SNX6, ACVR1B, MPRIP, COPS3, NLRX1, ELAC2, MON1B, ARF3, ARPIN, SPRYD3, FLI1, TIRAP, GSE1, POLR3K, PIGO, MFHAS1, NPIPA1, DPH6, ERLIN2, CES2, LHFP, NAIF1, ALCAM, SYNE1, SPINT1, SMTN, SLCA46A1, SAP25, WISP2, TSTD1, NLRX1, NPIPA1, HIST1H2AC, FUT8, FABP4, ERBB2, TUBA1A, XAGE1E, SERPINF1, RAI14, SIRPA, MT1X, NEK3, TGFB3, USP13, HLA-DRB4, IGF2, and MICAL1; and the statistical model includes variables representing ratios of gene expression levels for pairs of the predictor genes. accessing expression data for the subject; using the expression data to determine expression levels, in the subject, for at least three genes; and determining, using the determined expression levels and a statistical model trained using expression data indicating expression levels for a plurality of genes for a plurality of subjects, whether or not the subject is likely to respond to the checkpoint blockade therapy, wherein the checkpoint blockade therapy is a PD1 inhibitor and/or a CTLA4 inhibitor; characterized in that the at least three genes are selected from the set of predictor genes consisting of BRAF, ACVR1B, MPRIP, PRKAG1, STX2, AGPAT3, FYN, CMIP, ROBO4, RAB40C, HAUS8, SNAP23, SNX6, ACVR1B, MPRIP, COPS3, NLRX1, ELAC2, MON1B, ARF3, ARPIN, SPRYD3, FLI1, TIRAP, GSE1, POLR3K, PIGO, MFHAS1, NPIPA1, DPH6, ERLIN2, CES2, LHFP, NAIF1, ALCAM, SYNE1, SPINT1, SMTN, SLCA46A1, SAP25, WISP2, TSTD1, NLRX1, NPIPA1, HIST1H2AC, FUT8, FABP4, ERBB2, TUBA1A, XAGE1E, SERPINF1, RAI14, SIRPA, MT1X, NEK3, TGFB3, USP13, HLA-DRB4, IGF2, and MICAL1; and the statistical model includes variables representing ratios of gene expression levels for pairs of the predictor genes.
A process for the production of a compound of Formula: comprising the step of (i) the reaction of a compound of Formula, (6 R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-(5-methyl-2-methylsulfonyl-pyrimidin-4-yl)-5,6-dihydroimidazo[1,2-a]pyrazin-8-one: and 2-methylpyrazol-3-amine (VIII):
An apparatus comprising: a test point accessible from an exterior of an enclosure while the enclosure is in a closed state, the enclosure housing one or more electrical components (104, 106), the closed state preventing a user from touching the one or more electrical components, wherein the test point is for measuring an electric potential of a conductor; a test conductor connected to a point on the conductor connected to an electrical component of the one or more electrical components, the test conductor within the enclosure; an impedance connecting the test point to the test conductor, the impedance within the enclosure, the impedance is configured to limit current through the test point, wherein the impedance includes one or more resistors, and wherein the test point meets an Ingress Protection code rating of 20; a second test conductor connected to a second point on the conductor, the second test conductor within the enclosure; and a second impedance connecting the test point to the second test conductor, the second impedance within the enclosure. a test point accessible from an exterior of an enclosure while the enclosure is in a closed state, the enclosure housing one or more electrical components (104, 106), the closed state preventing a user from touching the one or more electrical components, wherein the test point is for measuring an electric potential of a conductor; a test conductor connected to a point on the conductor connected to an electrical component of the one or more electrical components, the test conductor within the enclosure; an impedance connecting the test point to the test conductor, the impedance within the enclosure, the impedance is configured to limit current through the test point, wherein the impedance includes one or more resistors, and wherein the test point meets an Ingress Protection code rating of 20; a second test conductor connected to a second point on the conductor, the second test conductor within the enclosure; and a second impedance connecting the test point to the second test conductor, the second impedance within the enclosure.
An apparatus for cache buffering, comprising: a cache controller (120,220); and a cache (110, 210, 310, 410, 510) and a memory device (111-1, 111-2, 111-X, 511) coupled to the cache controller, wherein the cache controller includes a number of buffers (122-1, 122-2, 122-Y, 222-1, 222-2, 222-Y, 322, 422-1, 422-2, 522) and wherein the cache controller is configured to: store data (330, 430) associated with a request (340-1, 440-1) in a first of the number of buffers in response to evicting the data from a cache line of the cache; search the first buffer for the data in response to receiving a subsequent request (340-2, 440-2, 440-3) for the data, wherein the first buffer is searched while the request (340-1, 440-1) is being serviced by evicting the data from the cache line to the memory device; and service the subsequent request (340-2, 440-2, 440-3) by locating the data in the first buffer and returning the data to a host. a cache controller (120,220); and a cache (110, 210, 310, 410, 510) and a memory device (111-1, 111-2, 111-X, 511) coupled to the cache controller, wherein the cache controller includes a number of buffers (122-1, 122-2, 122-Y, 222-1, 222-2, 222-Y, 322, 422-1, 422-2, 522) and wherein the cache controller is configured to: store data (330, 430) associated with a request (340-1, 440-1) in a first of the number of buffers in response to evicting the data from a cache line of the cache; search the first buffer for the data in response to receiving a subsequent request (340-2, 440-2, 440-3) for the data, wherein the first buffer is searched while the request (340-1, 440-1) is being serviced by evicting the data from the cache line to the memory device; and service the subsequent request (340-2, 440-2, 440-3) by locating the data in the first buffer and returning the data to a host. store data (330, 430) associated with a request (340-1, 440-1) in a first of the number of buffers in response to evicting the data from a cache line of the cache; search the first buffer for the data in response to receiving a subsequent request (340-2, 440-2, 440-3) for the data, wherein the first buffer is searched while the request (340-1, 440-1) is being serviced by evicting the data from the cache line to the memory device; and service the subsequent request (340-2, 440-2, 440-3) by locating the data in the first buffer and returning the data to a host.
A peptide dimer for use in prophylaxis or treatment of diarrhea, constipation, obesity, or inflammatory bowel disease, wherein: the peptide dimer comprises a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and a peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4, wherein the peptide consisting of the amino acid sequence of SEQ ID NO: 1 and the peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4 are bound through a disulfide bond between a cysteine residue of each peptide. the peptide dimer comprises a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and a peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4, wherein the peptide consisting of the amino acid sequence of SEQ ID NO: 1 and the peptide consisting of any one of the amino acid sequences of SEQ ID NOS: 2 to 4 are bound through a disulfide bond between a cysteine residue of each peptide.
Electrophoretic pixel comprising a fluid comprising nanoparticles provided inside of the pixel, a first electrode, a first transparent substrate, wherein the first electrode is provided on an inner side of the first substrate, a protective layer covering the first electrode, a second substrate opposite of the first substrate, the first and second substrate enclosing the pixel, a second electrode, wherein the second electrode is provided on the second substrate, wherein the second electrode comprises conductive elements covering 2.5-20% of the pixel area on the second substrate, the nanoparticles comprising a coating, a pigment, and preferably comprising a core, wherein the nanoparticles are adapted to be provided with a charge, a connection for a driver circuit for applying an electro-magnetic field to the first and second electrode, wherein in use the applied electro-magnetic field to the first and second electrode by the driver circuit provides movement of the nanoparticles from the first electrode to the second electrode and vice versa, characterized in that the first electrode is not patterned, wherein a size of the nanoparticles is from 20-100 nm, and wherein a distance between the first and second substrate smaller than 20 μm.
An optical isolation device comprising at least one optical isolation element, wherein the optical isolation element comprises a first holographic element, a second holographic element, a retarder and a reflective polariscope in this order, each of which comprises a light entrance surface and a light exit surface, wherein the first holographic element is an optical element configured to output the incident light that is incident on its light entrance surface at an incident angle that is a first angle in a range of greater than -90 degrees and less than 90 degrees with an output angle that is a second angle different from the first angle, wherein the second holographic element is an optical element configured to transmit the incident light that is incident on its light entrance surface or its light exit surface at an incident angle that is a third angle, and to reflect the incident light that is incident on its light entrance surface or its light exit surface at an incident angle that is a fourth angle different from the third angle in a direction parallel to the direction of the relevant incident light, wherein the second to fourth angles are each in a range of greater than 0 degrees and less than 90 degrees, or in a range of greater than -90 degrees and less than 0 degrees, wherein the absolute value of the difference between the second angle and the third angle is in a range of 0 degrees to 10 degrees, and wherein the absolute value of the sum of the third angle and the fourth angle is in a range of 0 degrees to 10 degrees. wherein the optical isolation element comprises a first holographic element, a second holographic element, a retarder and a reflective polariscope in this order, each of which comprises a light entrance surface and a light exit surface, wherein the first holographic element is an optical element configured to output the incident light that is incident on its light entrance surface at an incident angle that is a first angle in a range of greater than -90 degrees and less than 90 degrees with an output angle that is a second angle different from the first angle, wherein the second holographic element is an optical element configured to transmit the incident light that is incident on its light entrance surface or its light exit surface at an incident angle that is a third angle, and to reflect the incident light that is incident on its light entrance surface or its light exit surface at an incident angle that is a fourth angle different from the third angle in a direction parallel to the direction of the relevant incident light, wherein the second to fourth angles are each in a range of greater than 0 degrees and less than 90 degrees, or in a range of greater than -90 degrees and less than 0 degrees, wherein the absolute value of the difference between the second angle and the third angle is in a range of 0 degrees to 10 degrees, and wherein the absolute value of the sum of the third angle and the fourth angle is in a range of 0 degrees to 10 degrees.
Mowing head assembly, comprising: - a mowing head comprising a spool housing configured to receive therein a spool with wire for rotation relative to the spool housing; - a coupling configured to couple the spool and the spool housing non-rotatably relative to each other in a coupling position and to uncouple the spool relative to the spool housing in a releasing position; and - wherein a selectively actuable control is provided which is configured to carry the coupling from the coupling position to the releasing position.; characterized in that the coupling is arranged outside the spool housing of the mowing head. - a mowing head comprising a spool housing configured to receive therein a spool with wire for rotation relative to the spool housing; - a coupling configured to couple the spool and the spool housing non-rotatably relative to each other in a coupling position and to uncouple the spool relative to the spool housing in a releasing position; and - wherein a selectively actuable control is provided which is configured to carry the coupling from the coupling position to the releasing position.;
Decorative element, wherein the decorative element has a microstructure which generates an optical effect in incident light and/or in transmitted light, wherein the microstructure has a base area and several base elements in a first region (31, 32), which in each case have an increased or reduced element area in comparison to the base area, and an edge arranged between the element area and the base area, wherein the base area of the microstructure defines a base plane spanned by coordinate axes x and y, wherein the element areas of the base elements respectively run substantially parallel to the base plane, wherein in at least one or several first zones (333, 351) of the first region (31, 32), the element areas of the base elements and the base area are spaced apart by a first distance in a direction running perpendicular to the base plane in the direction of a coordinate axis z, said distance being selected in such a way that, due to interference of the light reflected on the base area and the element areas, in incident light and/or, due to interference of the light transmitted through the element areas and the base areas, in transmitted light, a colour is generated in the one or several first zones (333, 351), wherein the formation and/or positioning of the base elements in the first region (31, 32) or in at least one first section of the first region is pseudo-randomly varied, wherein the microstructure is designed in such a way that it generates the colour in the first diffraction order or in scattered light, wherein in the first region (31, 32) or in the at least one first section of the first region, one or several of the parameters: positioning of the base element, spacing apart of the base element from the nearest adjacent base element, shape- and/or area size of the projection of the base element onto the base plane and lateral preferential direction of the projection of the base element onto the base plane of the base elements arranged in the first region (31, 32) or in the at least one first section, is varied pseudo-randomly within a respective variation range pre-defined for the first region (31, 32) or respective first section, characterised in that the variation ranges are selected as follows: variation range for the parameter spacing of the base elements from the nearest adjacent base element: 0.4 μm to 50 μm, and/or variation range of the parameter area size of the projection of the base element onto the base plane: variation at least of a lateral dimension of the projection of the base element onto the base planes in a variation range of from 0.5 μm to 30 μm, wherein the spacing apart of the base elements from the nearest adjacent base element and/or at least one lateral dimension of the projection of the base element onto the base plane is or are pseudo-randomly varied.
A cross linear type solar heat collecting apparatus comprising a plurality of reflection lines (L1,L2...) and one reception line (c); the plurality of reflection lines (L1,L2...) being arranged in parallel in a row-wise direction i.e. in a south-north direction on earth; each of the plurality of reflection lines (L1,L2...) being provided with a heliostat composed of a plurality of mirror segments (1a,1b,1c...); the reception line (c) extending in a column-wise direction i. e. in an east-west direction that perpendicularly intersects the plurality of reflection lines (L1,L2...) and being disposed above the plurality of reflection lines (L1,L2...); the mirror segments (1a,1b,1c...) placed on each reflection line (L1, L2...) are arranged to be aligned in a row-wise i.e. south-north direction and are capable of undergoing adjustment to a turning angle in the column-wise direction i.e. in the east-west direction and in the row-wise direction i.e in the south-north direction, and rotation angles of the mirror segments (1a,1b,1c...) in a column-wise i.e. east-west direction on the reflection lines (L1,L2...) are adjusted together as a group, whereas rotation angles of the mirror segments (1a,1b,1c...) in the row-wise direction i.e. in the south-north direction are adjusted individually, the reception line (c) being provided with a single receiver; reflected light of sunlight that has impinged on each mirror segment (1a, 1b, 1c...) of the heliostat of the reflection line (L1,L2...) being radiated toward the reception line (c) while allowing the mirror segments (1a,1b,1c...) to undergo angle adjustment; and the receiver of the reception line (c) collecting heat of the reflected light of the sunlight radiated from the heliostat.
A rechargeable lithium battery comprising: a positive electrode (114, 12, 22, 32, 42), a negative electrode (112, 11, 21, 31, 41), and a separator (113, 13, 23, 33, 43) between the positive electrode and the negative electrode, wherein the separator comprises: a substrate (14, 24, 34, 44) comprising a first side facing the negative electrode and a second side facing the positive electrode; an organic layer (15, 25, 35, 45) coated onto the first side of the substrate and comprising an organic material; and an inorganic layer (16, 26, 36, 46) coated onto the second side of the substrate and comprising an inorganic material, wherein the organic material has a melting point lower than that of the substrate. a positive electrode (114, 12, 22, 32, 42), a negative electrode (112, 11, 21, 31, 41), and a separator (113, 13, 23, 33, 43) between the positive electrode and the negative electrode, wherein the separator comprises: a substrate (14, 24, 34, 44) comprising a first side facing the negative electrode and a second side facing the positive electrode; an organic layer (15, 25, 35, 45) coated onto the first side of the substrate and comprising an organic material; and an inorganic layer (16, 26, 36, 46) coated onto the second side of the substrate and comprising an inorganic material, wherein the organic material has a melting point lower than that of the substrate. a substrate (14, 24, 34, 44) comprising a first side facing the negative electrode and a second side facing the positive electrode; an organic layer (15, 25, 35, 45) coated onto the first side of the substrate and comprising an organic material; and an inorganic layer (16, 26, 36, 46) coated onto the second side of the substrate and comprising an inorganic material, wherein the organic material has a melting point lower than that of the substrate.
An isolated lytic phage specific for Acinetobacter baumannii, - being DSM 23599 phage, wherein the DSM 23599 phage is deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and has a deposition number DSM 23599, or - being selected from the group consisting of DSM 23600 phage and variants of the DSM 23600 phage, wherein the DSM 23600 phage is deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and has a deposition number DSM 23600, and wherein each of the variants of the DSM 23600 phage has one or more sequences selected from the group consisting of sequences having more than 80% homology to SEQ ID NO: 1 and 2 and encoding an RNA polymerase of the Acinetobacter baumannii phage, and SEQ ID NO: 3 and 4 and encoding a head-tail connector of the Acinetobacter baumannii phage, and has a genomic sequence with a homology of more than 80% compared to the genomic sequence of the DSM 23600 phage. - being DSM 23599 phage, wherein the DSM 23599 phage is deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and has a deposition number DSM 23599, or - being selected from the group consisting of DSM 23600 phage and variants of the DSM 23600 phage, wherein the DSM 23600 phage is deposited in DSMZ (German Collection of Microorganisms and Cell Cultures, Germany) and has a deposition number DSM 23600, and wherein each of the variants of the DSM 23600 phage has one or more sequences selected from the group consisting of sequences having more than 80% homology to SEQ ID NO: 1 and 2 and encoding an RNA polymerase of the Acinetobacter baumannii phage, and SEQ ID NO: 3 and 4 and encoding a head-tail connector of the Acinetobacter baumannii phage, SEQ ID NO: 1 and 2 and encoding an RNA polymerase of the Acinetobacter baumannii phage, and SEQ ID NO: 3 and 4 and encoding a head-tail connector of the Acinetobacter baumannii phage,
An internal combustion engine comprising a warm-up acceleration device, the device including: a circulation passage that causes a coolant to circulate to flow through the internal combustion engine; and a controller that controls the flow of the coolant through the internal combustion engine, wherein, during a warm-up of the internal combustion engine, the controller restricts the flow of the coolant through the internal combustion engine, characterized in that the controller maintains the restriction during nucleate boiling of the coolant in the internal combustion engine, the controller restricts the flow of the coolant through the internal combustion engine when a pressure in the circulation passage is less than a determination value Pa, and the determination value Pa is set in such a manner as to be equivalent to the pressure in the circulation passage at a time point when the boiling state of the coolant in the internal combustion engine shifts from nucleate boiling to film boiling. a circulation passage that causes a coolant to circulate to flow through the internal combustion engine; and a controller that controls the flow of the coolant through the internal combustion engine,