mhurhangee/ep-ind-claims huggingface dataset:
A method for producing a conjugated diene rubber, comprising the steps of: (a) forming a polymer block by polymerizing a monomeric mixture with a polymerization initiator in an inert solvent, the polymer block having an active terminal and containing 80 to 95% by weight of an isoprene monomeric unit and 5 to 20% by weight of an aromatic vinyl monomeric unit, the monomeric mixture containing isoprene and an aromatic vinyl monomer; (b) obtaining a conjugated diene polymer chain having an active terminal and having the polymer block and a polymer block and optionally another polymer block, the polymer block being formed continuously with the polymer block through the continuation of a polymerization reaction caused by mixing of the polymer block having the active terminal and either 1,3-butadiene or a monomeric mixture containing 1,3-butadiene and an aromatic vinyl monomer, the polymer block having an active terminal and containing 50 to 100% by weight of a 1,3-butadiene monomeric unit and 0 to 50% by weight of an aromatic vinyl monomeric unit, and optionally further forming another polymer block; and (c) bringing a denaturant into reaction with the active terminal of the conjugated diene polymer chain having the active terminal, the denaturant having three or more groups per molecule, the three or more groups being each at least either group selected from among an epoxy group and an alkoxy group, the reaction taking place insofar as the total molar ratio of an epoxy group(s) and/or an alkoxy group(s) in the denaturant with respect to the polymerization initiator used in the polymerization ranges from 0.1 to 1. (a) forming a polymer block by polymerizing a monomeric mixture with a polymerization initiator in an inert solvent, the polymer block having an active terminal and containing 80 to 95% by weight of an isoprene monomeric unit and 5 to 20% by weight of an aromatic vinyl monomeric unit, the monomeric mixture containing isoprene and an aromatic vinyl monomer; (b) obtaining a conjugated diene polymer chain having an active terminal and having the polymer block and a polymer block and optionally another polymer block, the polymer block being formed continuously with the polymer block through the continuation of a polymerization reaction caused by mixing of the polymer block having the active terminal and either 1,3-butadiene or a monomeric mixture containing 1,3-butadiene and an aromatic vinyl monomer, the polymer block having an active terminal and containing 50 to 100% by weight of a 1,3-butadiene monomeric unit and 0 to 50% by weight of an aromatic vinyl monomeric unit, and optionally further forming another polymer block; and (c) bringing a denaturant into reaction with the active terminal of the conjugated diene polymer chain having the active terminal, the denaturant having three or more groups per molecule, the three or more groups being each at least either group selected from among an epoxy group and an alkoxy group, the reaction taking place insofar as the total molar ratio of an epoxy group(s) and/or an alkoxy group(s) in the denaturant with respect to the polymerization initiator used in the polymerization ranges from 0.1 to 1.
An agent which elevates p38γ activity, or the activity of a variant of p38γ, in neurons of a subject, for use in treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, wherein the agent elevates p38γ activity or the activity of a variant of p38γ is an agent that: (a) elevates the amount of p38γ in the neuron; and/or (b) elevates the amount of a variant of p38γ in the neuron; and/or (c) elevates the amount of p38γ activation in the neuron; and/or (d) elevates the amount of activation of the variant of p38γ in the neuron, wherein p38γ activity or the activity of a variant of p38γ causes disruption of the tau-dependent signalling complex and is phosphorylation of tau at T205, wherein a variant of p38γ is a protein that phosphorylates tau at T205 and comprises a PDZ interaction motif comprising the amino acid sequence EPTL (SEQ ID NO: 8) or ETAL (SEQ ID NO: 32), and wherein the agent comprises a nucleic acid sequence, a nucleic acid analogue, a protein, or a peptide. wherein the agent elevates p38γ activity or the activity of a variant of p38γ is an agent that: (a) elevates the amount of p38γ in the neuron; and/or (b) elevates the amount of a variant of p38γ in the neuron; and/or (c) elevates the amount of p38γ activation in the neuron; and/or (d) elevates the amount of activation of the variant of p38γ in the neuron, (a) elevates the amount of p38γ in the neuron; and/or (b) elevates the amount of a variant of p38γ in the neuron; and/or (c) elevates the amount of p38γ activation in the neuron; and/or (d) elevates the amount of activation of the variant of p38γ in the neuron, wherein p38γ activity or the activity of a variant of p38γ causes disruption of the tau-dependent signalling complex and is phosphorylation of tau at T205, wherein a variant of p38γ is a protein that phosphorylates tau at T205 and comprises a PDZ interaction motif comprising the amino acid sequence EPTL (SEQ ID NO: 8) or ETAL (SEQ ID NO: 32), and wherein the agent comprises a nucleic acid sequence, a nucleic acid analogue, a protein, or a peptide.
A transmission shaft for driving an actuator in a wing of an aircraft comprising: a first side for inputting torque; a second side for outputting torque; and a rod extending in a longitudinal direction between the first side and the second side to transfer torque along the transmission shaft, the rod comprising a first end provided at the first side, a second end provided at the second side and a torsional compliant section extending therebetween providing the transmission shaft with a torsional stiffness, wherein the torsional compliant section comprises a cross-section which extends in the longitudinal direction to define a central core for transmitting torque directly from the first end to the second end and a radially outer section comprising a plurality ribs which extend radially and longitudinally from an outer periphery of the central core for increasing transverse stiffness of the rod, wherein the first end of the rod and the first side of the transmission shaft are coupled through a first circumferentially extending interface to deliver torque into the torsional compliant section, and the second end of the rod and the second side of the transmission shaft are coupled through a second circumferentially extending interface to deliver torque out of the torsional compliant section, wherein end surfaces of the ribs of the torsional compliant section are spaced from the first and second circumferentially extending interfaces; and wherein the rod comprises a composite material comprising fibres extending longitudinally the entire length of the rod. a first side for inputting torque; a second side for outputting torque; and a rod extending in a longitudinal direction between the first side and the second side to transfer torque along the transmission shaft, the rod comprising a first end provided at the first side, a second end provided at the second side and a torsional compliant section extending therebetween providing the transmission shaft with a torsional stiffness, wherein the torsional compliant section comprises a cross-section which extends in the longitudinal direction to define a central core for transmitting torque directly from the first end to the second end and a radially outer section comprising a plurality ribs which extend radially and longitudinally from an outer periphery of the central core for increasing transverse stiffness of the rod, wherein the first end of the rod and the first side of the transmission shaft are coupled through a first circumferentially extending interface to deliver torque into the torsional compliant section, and the second end of the rod and the second side of the transmission shaft are coupled through a second circumferentially extending interface to deliver torque out of the torsional compliant section, wherein end surfaces of the ribs of the torsional compliant section are spaced from the first and second circumferentially extending interfaces; and wherein the rod comprises a composite material comprising fibres extending longitudinally the entire length of the rod.
A fusion spine internal fixation screw, comprising a screw cap section and a bone joint section connected with the screw cap section, the bone joint section comprises a solid part and a porous fusion part fixedly arranged on a surface of the solid part; and the porous fusion part is provided with a porous structure inosculated with spine sclerotins, characterized in that the porous fusion part is a multilayered porous structure, which comprises a plurality of pores communicated with one another.
A method for preparing a cannabinoid concentrate comprising more than 50% by dry weight, with respect to the total dry weight of the concentrate, of cannabinoids and wherein the weight ratio (THCA):(other cannabinoid acids) is of less than 1:50, comprising the steps of: a) providing a lipid extract comprising at least 1% by dry weight, with respect to the total cannabinoids dry weight, of cannabinoid acids and wherein the weight ratio (THCA):(other cannabinoid acids) is of less than 1:2; b) mixing said lipid extract with an alkaline aqueous solution to form a mixture having a pH of at least 12; c) separating from the mixture of step b) an aqueous phase containing cannabinoid salts; and d) obtaining said cannabinoid concentrate, wherein before step c) at least one salt and/or at least one sugar is added to the mixture of step b), and said step c) of separating comprises separating from the mixture of step b): - a lighter oily phase, - an intermediate slimy phase, and - a heavier aqueous phase, wherein the heavier aqueous phase is the aqueous phase containing cannabinoid acid salts. a) providing a lipid extract comprising at least 1% by dry weight, with respect to the total cannabinoids dry weight, of cannabinoid acids and wherein the weight ratio (THCA):(other cannabinoid acids) is of less than 1:2; b) mixing said lipid extract with an alkaline aqueous solution to form a mixture having a pH of at least 12; c) separating from the mixture of step b) an aqueous phase containing cannabinoid salts; and d) obtaining said cannabinoid concentrate, - a lighter oily phase, - an intermediate slimy phase, and - a heavier aqueous phase, wherein the heavier aqueous phase is the aqueous phase containing cannabinoid acid salts.
Motor vehicle structure, comprising a roof cross-member, said cross-member comprising two ends fixed to arch beams of said roof, the cross-member having at each of the two ends a section with a non-rectilinear horizontal profile comprising two opposite lateral portions and a central portion cantilevered between said lateral portions, said central portion being capable of bending towards the corresponding roof arc beam in the event of a corresponding force exerted on the cross-member, said structure being characterized in that each of the two roof arc beams has an opposite indentation (9C, 11C) facing the central portion of the corresponding end section of the crosspiece, allowing said portion to bend.
A memory device, comprising: a connection that is operable to transmit signals to and from a memory controller and firmware; a first memory region and a second memory region; and a memory buffer coupling the first memory region and the second memory region to the connection, wherein the memory buffer is operable, in response to operations performed by the firmware, to perform copy operations without instruction from the memory controller in order to copy data from the first memory region to the second memory region, and wherein the memory buffer is further operable to route requests from the memory controller to one of the first memory region and the second memory region; wherein the first memory region is a failing memory region and the second memory region is a spare memory, region; Characterized in that the operations performed by the firmware include an instruction provided by the firmware to the memory controller to produce at least one additional calibration operation time period and the provision of the at least one additional calibration operation time period by the firmware to the memory buffer, and wherein the memory buffer performs the copy operations without instruction from the memory controller during the at least one additional calibration operation time period. a connection that is operable to transmit signals to and from a memory controller and firmware; a first memory region and a second memory region; and a memory buffer coupling the first memory region and the second memory region to the connection, wherein the memory buffer is operable, in response to operations performed by the firmware, to perform copy operations without instruction from the memory controller in order to copy data from the first memory region to the second memory region, and wherein the memory buffer is further operable to route requests from the memory controller to one of the first memory region and the second memory region;
A testing method for a DC circuit breaker to verify a current breaking performance using a testing device comprising a current source circuit and a voltage source circuit, the method comprising: supplying an AC current from at least the current source circuit to the DC circuit breaker; breaking the current by the DC circuit breaker at a time the current becomes equivalent to a fault current due to a system accident in a DC system; and applying a voltage to the DC circuit breaker, before the current breaking, by connecting the voltage source circuit to the DC circuit breaker, and applying a predetermined recovery voltage from the voltage source circuit simultaneously with the current breaking, wherein: the voltage source circuit comprises a capacitor serving as a voltage source; and the connection of the voltage source circuit to the DC circuit breaker is set to be a timing immediately before the current breaking, wherein the timing immediately before the current breaking means the timing at which the voltage source circuit is capable of applying, to the DC circuit breaker, the predetermined recovery voltage, at a time of the current breaking, characterized in that: the current source circuit supplies an AC current less than a current equivalent to the fault current to the DC circuit breaker; and the voltage source circuit is connected to the DC circuit breaker before the current breaking by the DC circuit breaker, to superimpose a current from the voltage source circuit on the current of the current source circuit to obtain the current equivalent to the fault current, and to apply a voltage to the DC circuit breaker. supplying an AC current from at least the current source circuit to the DC circuit breaker; breaking the current by the DC circuit breaker at a time the current becomes equivalent to a fault current due to a system accident in a DC system; and applying a voltage to the DC circuit breaker, before the current breaking, by connecting the voltage source circuit to the DC circuit breaker, and applying a predetermined recovery voltage from the voltage source circuit simultaneously with the current breaking, the voltage source circuit comprises a capacitor serving as a voltage source; and the connection of the voltage source circuit to the DC circuit breaker is set to be a timing immediately before the current breaking, wherein the timing immediately before the current breaking means the timing at which the voltage source circuit is capable of applying, to the DC circuit breaker, the predetermined recovery voltage, at a time of the current breaking, the current source circuit supplies an AC current less than a current equivalent to the fault current to the DC circuit breaker; and the voltage source circuit is connected to the DC circuit breaker before the current breaking by the DC circuit breaker, to superimpose a current from the voltage source circuit on the current of the current source circuit to obtain the current equivalent to the fault current, and to apply a voltage to the DC circuit breaker.
A hydrogel-formable composition capable of forming a hydrogel having a self-supporting property, the hydrogel-formable composition characterized by comprising: a water-soluble organic polymer having an organic acid structure, an organic acid salt structure, or an organic acid anion structure; a silicate; a compound having a diphosphonic acid structure of Formula: (wherein R 1 and R 2 each are independently a hydrogen atom, hydroxy group, a halogen atom, an optionally substituted linear, branched, or cyclic alkyl group, alkyloxy group, or alkylthio group having a carbon number of 1 to 12, an optionally substituted amino group, an optionally substituted monovalent C 6-12 aromatic group, or a monovalent C 3-12 heteroaromatic group having at least one nitrogen atom, oxygen atom, or sulfur atom as a ring-forming atom; X 1 and X 2 each are independently a single bond or a linking group; and n is an integer of 1 to 5) or a salt thereof; and a compound having or generating a positive charge of divalent or more. R 1 and R 2 each are independently a hydrogen atom, hydroxy group, a halogen atom, an optionally substituted linear, branched, or cyclic alkyl group, alkyloxy group, or alkylthio group having a carbon number of 1 to 12, an optionally substituted amino group, an optionally substituted monovalent C 6-12 aromatic group, or a monovalent C 3-12 heteroaromatic group having at least one nitrogen atom, oxygen atom, or sulfur atom as a ring-forming atom; X 1 and X 2 each are independently a single bond or a linking group; and n is an integer of 1 to 5) or a salt thereof; and a compound having or generating a positive charge of divalent or more.
A method for modifying a composite article, comprising: creating a depression at a site on the composite article, the depression being in the form of an inverted cone or inverted prism; positioning a plug comprising composite material in the depression, the plug having an appropriate shape and size for positioning therein; rotating at least one of the plug and the article at a rate of speed sufficient to form an inertia bond between the plug and the site of the composite article; and engaging the plug and the site to effect an inertia bond therebetween. creating a depression at a site on the composite article, the depression being in the form of an inverted cone or inverted prism; positioning a plug comprising composite material in the depression, the plug having an appropriate shape and size for positioning therein; rotating at least one of the plug and the article at a rate of speed sufficient to form an inertia bond between the plug and the site of the composite article; and engaging the plug and the site to effect an inertia bond therebetween.
- A method for manufacturing and implementing, in a room, a ceiling including vertical slats, the method comprising the following steps: - a step of making a frame comprising at least two parallel rails, - a step of securing an anchor plate provided with first holes to each rail, - a step of attaching the frame provided with the anchor plates to its intended location in the room, - a step of crafting several counter-laths each provided with several parallel slats and having second holes, - a step of positioning each counter-lath between the two anchor plates so as to superimpose a second hole of the counter-lath with a first hole of each anchor plate, - a step of attaching each counter-lath to the two plates, by inserting two pins into the first and second superimposed holes. - a step of making a frame comprising at least two parallel rails, - a step of securing an anchor plate provided with first holes to each rail, - a step of attaching the frame provided with the anchor plates to its intended location in the room, - a step of crafting several counter-laths each provided with several parallel slats and having second holes, - a step of positioning each counter-lath between the two anchor plates so as to superimpose a second hole of the counter-lath with a first hole of each anchor plate, - a step of attaching each counter-lath to the two plates, by inserting two pins into the first and second superimposed holes.
A method for removing a tattoo in a region of skin the method comprising: administering to at least a portion of the tattoo, a composition comprising an effective amount of a bisphosphonate and at least one pharmaceutically acceptable excipient to at least cause fading of the tattoo in said region.
A compound according to Formula: wherein A is substituted or unsubstituted isoquinolin-6-yl, wherein the isoquinoline radical may be mono- or disubstituted with halogen, cyano, nitro or C 1 -C 4 alkyl; R 1, R 2, R 3, R 4, and R 5 are, independently, hydrogen, halogen, C 1 -C 8 alkyl, alkoxy, phenoxy, -OR 7, amino, nitro, cyano, aryl, C 1 - C 4 alkylaryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl; R 7 is C 1 -C 4 alkyl, aryl, heteroaryl, C 1 -C 4 alkyl aryl or C 1 -C 4 alkyl heteroaryl; X is and R 6 is CH 2 or CH(C 1 -C 4 alkyl). wherein A is substituted or unsubstituted isoquinolin-6-yl, wherein the isoquinoline radical may be mono- or disubstituted with halogen, cyano, nitro or C 1 -C 4 alkyl; R 1, R 2, R 3, R 4, and R 5 are, independently, hydrogen, halogen, C 1 -C 8 alkyl, alkoxy, phenoxy, -OR 7, amino, nitro, cyano, aryl, C 1 - C 4 alkylaryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl; R 7 is C 1 -C 4 alkyl, aryl, heteroaryl, C 1 -C 4 alkyl aryl or C 1 -C 4 alkyl heteroaryl; X is and R 6 is CH 2 or CH(C 1 -C 4 alkyl).
Mobile working machine, in particular wheel loader, telescopic loader, excavator, tractor or the like, having a vehicle frame and having a drive unit for driving at least one drive running wheel or a drive chain, wherein the drive unit comprises at least one electric motor and at least one electrical energy store for storing electrical energy for the electric motor, wherein at least one control unit is provided for electrically and/or electronically controlling the electric motor and/or the energy store, wherein at least one tool holding device is provided for holding a working tool, wherein in particular the tool holding device comprises at least one carrying device pivotable about a pivot axis, for example a lifting arm and/or a telescopic boom and/or a three-point lifting device, wherein at least one air conveying device, in particular a fan or blower, is provided for generating a cooling air flow (10, 12), and wherein at least one cooling air guiding device (5, 7, 8, 9, 14, 17) is provided for guiding/leading the cooling air flow (10, 12) from the energy store at least to the electric motor and/or to the control unit, wherein the air conveying device is arranged between the energy store and the electric motor, wherein the cooling air guiding device (5, 7, 8, 9, 14, 17) comprises at least one duct portion and/or one cooling air pipe for the cooling air flow (10, 12) to flow through, wherein the duct portion and/or the cooling air pipe have/has a duct/pipe wall transverse to the flow direction of the cooling air flow, characterized in that at least one cooling hood is arranged on the electric motor, so that the cooling air flow (10, 12) is arranged between the cooling hood and the electric motor, wherein the cooling hood covers the electric motor and guides/leads the cooling air flow (10, 12) in the intermediate space between the cooling hood and the electric motor, wherein the duct portion and/or the cooling air pipe form/forms the cooling hood.