mhurhangee/ep-ind-claims huggingface dataset:
A compound according to Formula 1000: or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, wherein: Ar is a divalent six-membered, substituted or unsubstituted, monocyclic aryl; a divalent five- or six-membered, substituted or unsubstituted, monocyclic heteroaryl; a divalent nine- or ten-membered, substituted or unsubstituted, fused bicyclic aryl; a divalent eight-, nine- or ten-membered, substituted or unsubstituted, fused bicyclic heteroaryl; L is absent or -CH2-; W 1, W 2, W 3, W 4, and W 5 are each independently a single bond, absent, or a divalent attaching group; EG is absent or an eliminator group; each RT is a release trigger group, in the backbone of Formula 1000 or bonded to EG, wherein each RT is optional; RT 1 is a release trigger group, or a cleavable linker, or RT 1 is absent; HP is a single bond, absent, or a divalent hydrophilic group; HP 1 is a single bond, absent, a divalent hydrophilic group, or where R HP is a monovalent hydrophilic group; SG is a single bond, absent, or a divalent spacer group; and R is Ar is a divalent six-membered, substituted or unsubstituted, monocyclic aryl; a divalent five- or six-membered, substituted or unsubstituted, monocyclic heteroaryl; a divalent nine- or ten-membered, substituted or unsubstituted, fused bicyclic aryl; a divalent eight-, nine- or ten-membered, substituted or unsubstituted, fused bicyclic heteroaryl; L is absent or -CH2-; W 1, W 2, W 3, W 4, and W 5 are each independently a single bond, absent, or a divalent attaching group; EG is absent or an eliminator group; each RT is a release trigger group, in the backbone of Formula 1000 or bonded to EG, wherein each RT is optional; RT 1 is a release trigger group, or a cleavable linker, or RT 1 is absent; HP is a single bond, absent, or a divalent hydrophilic group; HP 1 is a single bond, absent, a divalent hydrophilic group, or where R HP is a monovalent hydrophilic group; SG is a single bond, absent, or a divalent spacer group; and R is
A method for manufacturing a glass run seal assembly, characterized by, performing the steps of: - extruding an elastomeric material forming individual first and second legs (411, 412) for a first portion intended to form a glass run channel; - simultaneously extruding a thermoplastic material forming a second portion having a generally U-shaped cross section defining an attachment channel, the second portion having first and second legs (421, 422) with edges joined by a base web, and a further base web bonding with the extruded elastomeric material of the first and second legs (411, 412) of the first portion to form a generally U-shaped cross section defining the glass run channel, the further base web being integral with an edge of the first leg of the second portion; - inserting a reinforcement into the second leg of the second portion during extrusion of the thermoplastic material, wherein the co-extruded materials form a glass run seal assembly; and - cooling the glass run seal assembly and allowing the first leg of the second portion and the extruded first and second legs (411, 412) of the first portion to shrink in the longitudinal direction relative to the reinforced second leg of the second portion, forming a glass run seal assembly having a predetermined curvature in the longitudinal direction of the glass run assembly imparted by the reinforcement in the second leg. - extruding an elastomeric material forming individual first and second legs (411, 412) for a first portion intended to form a glass run channel; - simultaneously extruding a thermoplastic material forming a second portion having a generally U-shaped cross section defining an attachment channel, the second portion having first and second legs (421, 422) with edges joined by a base web, and a further base web bonding with the extruded elastomeric material of the first and second legs (411, 412) of the first portion to form a generally U-shaped cross section defining the glass run channel, the further base web being integral with an edge of the first leg of the second portion; - inserting a reinforcement into the second leg of the second portion during extrusion of the thermoplastic material, wherein the co-extruded materials form a glass run seal assembly; and - cooling the glass run seal assembly and allowing the first leg of the second portion and the extruded first and second legs (411, 412) of the first portion to shrink in the longitudinal direction relative to the reinforced second leg of the second portion, forming a glass run seal assembly having a predetermined curvature in the longitudinal direction of the glass run assembly imparted by the reinforcement in the second leg.
A conveyor joint assembly comprising: a support ledge operably coupled to and extending from a first sealing surface, a first side wall and second side wall operably coupled to opposite ends of the support ledge; at least one protrusion operably coupled to a second sealing surface, wherein the second sealing surface is configured to engage the support ledge; the conveyor joint assembly being characterised in that it further comprises receivers in the form of a groove or slot in the first and second side walls or a gap formed between the first and second side walls and the first sealing surface, operably coupled to the first sealing surface and configured to retain a respective one of the at least one protrusions to cause the first sealing surface to engage the second sealing surface. a support ledge operably coupled to and extending from a first sealing surface, a first side wall and second side wall operably coupled to opposite ends of the support ledge; at least one protrusion operably coupled to a second sealing surface, wherein the second sealing surface is configured to engage the support ledge; the conveyor joint assembly being characterised in that it further comprises receivers in the form of a groove or slot in the first and second side walls or a gap formed between the first and second side walls and the first sealing surface, operably coupled to the first sealing surface and configured to retain a respective one of the at least one protrusions to cause the first sealing surface to engage the second sealing surface.
An inhaler (100; 300) comprising: a mouthpiece (170; 370); a mouthpiece cover (180; 380) movable between an open position and a closed position; a dosing cup; a medication reservoir configured to deliver a dose of medication into the dosing cup upon the mouthpiece cover moving from the closed position to the open position; a pressure sensor (410; 610) configured to monitor flows associated with breathing; a single light indicator (152; 452; 552); and a processor (150; 250; 457; 550; 650) configured to control the single light indicator to be in a first state (810; 910) when the mouthpiece cover is in the closed position, a second state (820; 920) when the mouthpiece cover is in the open position, an optional third state (830; 930) when the inhaler makes a pressure measurement, and a fourth state (840; 940) upon detecting that the measured pressure exceeds a predetermined amount. a mouthpiece (170; 370); a mouthpiece cover (180; 380) movable between an open position and a closed position; a dosing cup; a medication reservoir configured to deliver a dose of medication into the dosing cup upon the mouthpiece cover moving from the closed position to the open position; a pressure sensor (410; 610) configured to monitor flows associated with breathing; a single light indicator (152; 452; 552); and a processor (150; 250; 457; 550; 650) configured to control the single light indicator to be in a first state (810; 910) when the mouthpiece cover is in the closed position, a second state (820; 920) when the mouthpiece cover is in the open position, an optional third state (830; 930) when the inhaler makes a pressure measurement, and a fourth state (840; 940) upon detecting that the measured pressure exceeds a predetermined amount.
A wave-powered device, WPD, comprising: 1) a float; 2) a wave-actuated component; and 3) a tether having a first end connected to the float and a second end connected to the wave-actuated component, wherein when the float is placed on or near the surface of still water, the float floats on or near the surface of the still water, the tether extends downwards from the float and under tension, and the wave-actuated component is submerged below the float, and when the float is placed on or near the surface of wave-bearing water, the float floats on or near the surface of the wave-bearing water, the tether extends downwards from the float, and the wave-actuated component is submerged below the float, and interacts with the water to generate forces that are transmitted to the tether, wherein the WPD is characterized in that: the WPD further comprises a closure component including a winch, the winch having a spool to which the first end of the tether is connected, the winch further having: a first state in which the tether is wound onto the spool to secure the float and the wave-actuated component together as an assembly that can be moved as a unit, and a second state in which the tether is unwound from the spool to permit the wave-actuated component to move away from the float; and the winch is mounted to pivot about the pitch axis. 1) a float; 2) a wave-actuated component; and 3) a tether having a first end connected to the float and a second end connected to the wave-actuated component, wherein the float floats on or near the surface of the still water, the tether extends downwards from the float and under tension, and the wave-actuated component is submerged below the float, and the float floats on or near the surface of the wave-bearing water, the tether extends downwards from the float, and the wave-actuated component is submerged below the float, and interacts with the water to generate forces that are transmitted to the tether, the WPD further comprises a closure component including a winch, the winch having a spool to which the first end of the tether is connected, the winch further having: a first state in which the tether is wound onto the spool to secure the float and the wave-actuated component together as an assembly that can be moved as a unit, and a second state in which the tether is unwound from the spool to permit the wave-actuated component to move away from the float; and a first state in which the tether is wound onto the spool to secure the float and the wave-actuated component together as an assembly that can be moved as a unit, and a second state in which the tether is unwound from the spool to permit the wave-actuated component to move away from the float; and the winch is mounted to pivot about the pitch axis.
A system, comprising: a microphone array comprising a plurality of microphones (14, 16) positioned at different locations, where the microphones output microphone signals; and a beamformer that is applied to the microphone output signals and is configured to control a gain that is applied to the microphone output signals, where the gain is frequency dependent and is related to a mismatch in sensitivity between two or more of the microphones, characterized in that the beamformer is configured to reduce the gain that is applied to the microphone output signals more at lower input frequencies than at higher input frequencies, and wherein the beamformer is a minimum variance distortionless response (MVDR) beamformer configured to perform no gain reduction at 2000 Hz and above. a microphone array comprising a plurality of microphones (14, 16) positioned at different locations, where the microphones output microphone signals; and a beamformer that is applied to the microphone output signals and is configured to control a gain that is applied to the microphone output signals, where the gain is frequency dependent and is related to a mismatch in sensitivity between two or more of the microphones, characterized in that the beamformer is configured to reduce the gain that is applied to the microphone output signals more at lower input frequencies than at higher input frequencies, and wherein the beamformer is a minimum variance distortionless response (MVDR) beamformer configured to perform no gain reduction at 2000 Hz and above.
A time-resolved fluorescence energy resonance transfer TR-FRET method of determining the presence or absence, independently, of a first analyte and a second analyte on a single substrate in a sample; wherein the substrate is labeled with an affinity tag selected from the group consisting of biotin, digoxigenin, fluorescein, dinitrophenol, FLAG, HisTag, cmyc, HA, V5, and streptag; and wherein the first analyte and second analyte each, independently, comprise a post-translational modification of a peptide selected from the group consisting of phosphorylation, methylation, acetylation, glycosylation, ubiquitination, and sumoylation, the method comprising: contacting the sample with a first analyte-specific binding partner bound to a first FRET acceptor capable of being excited by light with a wavelength of about 600 to 635 nm, a second analyte-specific binding partner bound to a second FRET acceptor capable of being excited by light with a wavelength of about 675 to 715 nm, and a compound comprising a europium chelate moiety that is capable of exciting the first FRET acceptor and the second FRET acceptor, wherein the compound comprising the europium chelate moiety comprises an affinity tag-specific binding partner that is specific for the affinity tag of the substrate; exposing the sample to light in a wavelength range of about 315 to 350 nm; and determining, independently, based on detecting an emission light of the sample, if the first analyte-specific binding partner and the second analyte-specific binding partner bind to the first analyte and second analyte, respectively, thereby detecting the presence or absence, independently, of the two analytes in the sample. contacting the sample with a first analyte-specific binding partner bound to a first FRET acceptor capable of being excited by light with a wavelength of about 600 to 635 nm, a second analyte-specific binding partner bound to a second FRET acceptor capable of being excited by light with a wavelength of about 675 to 715 nm, and a compound comprising a europium chelate moiety that is capable of exciting the first FRET acceptor and the second FRET acceptor, wherein the compound comprising the europium chelate moiety comprises an affinity tag-specific binding partner that is specific for the affinity tag of the substrate; exposing the sample to light in a wavelength range of about 315 to 350 nm; and determining, independently, based on detecting an emission light of the sample, if the first analyte-specific binding partner and the second analyte-specific binding partner bind to the first analyte and second analyte, respectively, thereby detecting the presence or absence, independently, of the two analytes in the sample.
A method for searching a playback timing of multimedia content in an image display device, the method comprising: playing multimedia content; displaying an activated first image navigation bar and an inactivated second image navigation bar during the multimedia content playing; detecting a touch input on the first image navigation bar; determining a precision search section based on the detected touch input; inactivating the first image navigation bar and activating the second image navigation bar; matching the precision search section to the second image navigation bar; detecting a touch input on the second image navigation bar; and changing a play timing of the multimedia content based on the touch input on the second image navigation bar, wherein the inactivating further comprises controlling the inactivated first image navigation bar to cease interaction between a user and the first image navigation bar. playing multimedia content; displaying an activated first image navigation bar and an inactivated second image navigation bar during the multimedia content playing; detecting a touch input on the first image navigation bar; determining a precision search section based on the detected touch input; inactivating the first image navigation bar and activating the second image navigation bar; matching the precision search section to the second image navigation bar; detecting a touch input on the second image navigation bar; and changing a play timing of the multimedia content based on the touch input on the second image navigation bar, wherein the inactivating further comprises controlling the inactivated first image navigation bar to cease interaction between a user and the first image navigation bar.
A method for handling terminations in a media gateway, MG, or a media gateway controller, MGC,, the method characterized by the steps of: - receiving a message relating to one termination, containing a grouping parameter, - storing the grouping parameter in connection with said one termination, - receiving a command addressed to all contexts and all terminations, the command containing a grouping parameter or a Boolean expression of grouping parameters, - checking each termination, whether the grouping parameter or Boolean expression of grouping parameters contained in the received command corresponds to the grouping parameters stored in connection with each termination, and - executing the command for each termination where the grouping parameter or Boolean expression of grouping parameters contained in the received command corresponds to the grouping parameters stored in connection with each termination. - receiving a message relating to one termination, containing a grouping parameter, - storing the grouping parameter in connection with said one termination, - receiving a command addressed to all contexts and all terminations, the command containing a grouping parameter or a Boolean expression of grouping parameters, - checking each termination, whether the grouping parameter or Boolean expression of grouping parameters contained in the received command corresponds to the grouping parameters stored in connection with each termination, and - executing the command for each termination where the grouping parameter or Boolean expression of grouping parameters contained in the received command corresponds to the grouping parameters stored in connection with each termination.
A cosmetic composition comprising a low molecular weight silk fibroin and a cosmetically acceptable carrier; wherein said low molecular weight silk fibroin comprises at least 85 parts by weight peptides of molecular weight less than 2500 Da, where amino acid sequence of at least 50 wt% of said peptides is GAGY, GAGAGAGY, GAGVGAGY or AWSSESDF and where said silk fibroin is produced by a process comprising the steps of: (i) mixing an aqueous solution comprising 0.01 to 20 wt% of a high molecular weight silk fibroin of weight average molecular weight 6 to 100 KDa with α-chymotrypsin at temperature of 25 to 45°C, under pH of 6 to 9 for 4 to 24 hours, where ratio of said high molecular weight silk fibroin to said α-chymotrypsin in said solution is from 100:1 to 300:1 parts by weight; (ii) inactivating excess α-chymotrypsin and separating the inactivated α-chymotrypsin from reaction mixture of step (i); and, (iii) drying said reaction mixture to obtain said low molecular weight silk fibroin; wherein said composition comprises 0.1 to 10 wt% by weight of the low molecular weight silk fibroin; wherein said low molecular weight silk fibroin comprises tyrosine and its mole fraction in said low molecular weight silk fibroin is not less than 10 mol%; wherein said composition is a hair care composition. (i) mixing an aqueous solution comprising 0.01 to 20 wt% of a high molecular weight silk fibroin of weight average molecular weight 6 to 100 KDa with α-chymotrypsin at temperature of 25 to 45°C, under pH of 6 to 9 for 4 to 24 hours, where ratio of said high molecular weight silk fibroin to said α-chymotrypsin in said solution is from 100:1 to 300:1 parts by weight; (ii) inactivating excess α-chymotrypsin and separating the inactivated α-chymotrypsin from reaction mixture of step (i); and, (iii) drying said reaction mixture to obtain said low molecular weight silk fibroin;
Method for decontaminating radioactively contaminated workpieces, wherein a current workpiece of a workpiece sequence that is to be decontaminated passes through a process step chain having sequential process steps in a decontamination system, wherein the process steps comprise a cleaning step for cleaning contaminants off the current workpiece and a subsequent contamination measurement step for measuring a contamination of the current workpiece, wherein at least one process step is performed in a manner supported at least in part by data processing technology and based on a control parameter control parameter step - and wherein a measurement value is ascertained by way of sensor means on the current workpiece in the process step chain, characterized in that the control parameter for a workpiece of the workpiece sequence that follows the current workpiece is determined based on the measurement value which has been ascertained on the current workpiece.
Method for operating a device according to claim 7, characterised in that - the sensor, one end of which is immersed in the adhesive, or the end of the sensor that is spaced apart from the adhesive comprises a variable electrical field corresponding to the immersion depth or corresponding to the distance from the adhesive, respectively, - the variable electrical field is detected and evaluated by an open-loop/closed-loop control system for maintaining a predefined adhesive level and correspondingly filling the container. - the sensor, one end of which is immersed in the adhesive, or the end of the sensor that is spaced apart from the adhesive comprises a variable electrical field corresponding to the immersion depth or corresponding to the distance from the adhesive, respectively, - the variable electrical field is detected and evaluated by an open-loop/closed-loop control system for maintaining a predefined adhesive level and correspondingly filling the container.
An in vitro method of comparing effectiveness of an antitumor compound against a plurality of primary tumor cells, comprising introducing a plurality of primary tumor cells to a mammalian placenta or portion thereof, contacting said plurality of primary tumor cells for a period of time with said antitumor compound, determining the effectiveness of said antitumor compound against said primary tumor cells by evaluating the level said antitumor compound over said period of time reduces the number of said primary tumor cells or reduces the growth rate of said primary tumor cells, and comparing the effectiveness of said antitumor compound against said primary tumor cells with primary tumor cells not contacted with said antitumor compound.
A composition comprising (a) a yeast lysate; and (b) a flavor composition comprising: (i) a soy masking composition comprising steviol glycosides having additional glucose units added to the base steviol glycoside molecules via enzymatic glucosylation; and (ii) a vanilla flavor composition comprising vanillin or (iii) a cream flavor composition comprising lactones; and (c) a non-animal protein; wherein a concentration of yeast lysate in the composition ranges from 0.0025 weight percent to 0.2 weight percent, based on the total weight of the composition. (a) a yeast lysate; and (b) a flavor composition comprising: (i) a soy masking composition comprising steviol glycosides having additional glucose units added to the base steviol glycoside molecules via enzymatic glucosylation; and (ii) a vanilla flavor composition comprising vanillin or (iii) a cream flavor composition comprising lactones; and (c) a non-animal protein; wherein a concentration of yeast lysate in the composition ranges from 0.0025 weight percent to 0.2 weight percent, based on the total weight of the composition.