mhurhangee/ep-ind-claims huggingface dataset:
A method for obtaining a mixture containing two or more proteins by using single recombinant cell clone, wherein the proteins are in the form of a dimer which is formed by polymerization between monomer chains, and the two or more proteins contain the same domain, wherein the method comprises the step of replacing part of amino acid residues of the two monomer chains in the same domain of one or more proteins with the opposite-charged residues, so that the monomer chains from different proteins are unfavorable to form a heterodimer due to the repulsive interaction between like charges, while the monomer chain from the same protein is more favorable to form a homodimer due to the attractive interaction between opposite charges; wherein the same domain refers to CH3 domain of an antibody or Fc region of an antibody; wherein replacing part of amino acid residues of the two monomer chains in the same domains of one or more proteins with the opposite-charged residue refers to: 1) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein; 2) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein; and simultaneously, replacing Glu at position 357 with Lys and replacing Lys at position 370 with Glu of another protein; or 3) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein, and simultaneously, replacing Glu at position 356 with Lys and replacing Lys at position 439 with Glu of another protein; and wherein the positions of the residues are determined according to the EU numbering index of the KABAT system for antibodies. 1) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein; 2) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein; and simultaneously, replacing Glu at position 357 with Lys and replacing Lys at position 370 with Glu of another protein; or 3) replacing Lys at position 392 with Asp, replacing Lys at position 409 with Asp and replacing Asp at position 399 with Lys of one protein, and simultaneously, replacing Glu at position 356 with Lys and replacing Lys at position 439 with Glu of another protein; and wherein the positions of the residues are determined according to the EU numbering index of the KABAT system for antibodies.
A polymer composition, which is a silanol condensation catalyst masterbatch, comprising a matrix, a silane containing drying agent and at least one silanol condensation catalyst, wherein each catalyst has a water content which is 0.1 % by weight, or lower, and is selected from: i) a compound of formula I ArSO 3 H or a precursor thereof, wherein Ar is an 1 to 4 alkyl groups substituted aryl, wherein the aryl is phenyl or naphthyl, and wherein each alkyl group, independently, is a linear or branched alkyl with 10 to 30 carbons, wherein the total number of carbons in the alkyl groups is in the range of 20 to 80 carbons; ii) a derivative of i) selected from the group consisting of an anhydride, an ester, an acetylate, an epoxy blocked ester and an amine salt thereof which is hydrolysable to the corresponding compound of formula I; and iii) a metal salt of i) wherein the metal ion is selected from the group consisting of copper, aluminum, tin and zinc. i) a compound of formula I ArSO 3 H or a precursor thereof, wherein Ar is an 1 to 4 alkyl groups substituted aryl, wherein the aryl is phenyl or naphthyl, and wherein each alkyl group, independently, is a linear or branched alkyl with 10 to 30 carbons, wherein the total number of carbons in the alkyl groups is in the range of 20 to 80 carbons; or a precursor thereof, wherein Ar is an 1 to 4 alkyl groups substituted aryl, wherein the aryl is phenyl or naphthyl, and wherein each alkyl group, independently, is a linear or branched alkyl with 10 to 30 carbons, wherein the total number of carbons in the alkyl groups is in the range of 20 to 80 carbons; ii) a derivative of i) selected from the group consisting of an anhydride, an ester, an acetylate, an epoxy blocked ester and an amine salt thereof which is hydrolysable to the corresponding compound of formula I; and iii) a metal salt of i) wherein the metal ion is selected from the group consisting of copper, aluminum, tin and zinc.
Stretch-rolling device for pressure-reshaping of workpieces by rolling, which comprises: a work roll pair with two rolls which are respectively rotatable about the roll axes thereof and form a rolling gap therebetween, wherein the rolls in axial direction realise a plurality of stages (S1 to S4) which are arranged for reshaping of the workpieces in steps in that the workpieces successively run through the stages (S1 to S4); a manipulator with a plurality of gripper devices which are disposed on a work side of the work roll pair and are arranged to grip the workpieces and at an associated stage (S1 to S4) to lead them through the rolling gap in a feed/return direction; and a repository arranged to temporarily support workpieces and in co-operation with the manipulator to transfer them to another gripper device, preferably the adjacent gripper device of the next-higher stage (S2 to S4); characterised in that the gripper devices are arranged to grip the workpieces at one end and to guide them to an associated stage (S1 to S4) via the rolling gap, wherein the workpieces are not gripped at the other end. a work roll pair with two rolls which are respectively rotatable about the roll axes thereof and form a rolling gap therebetween, wherein the rolls in axial direction realise a plurality of stages (S1 to S4) which are arranged for reshaping of the workpieces in steps in that the workpieces successively run through the stages (S1 to S4); a manipulator with a plurality of gripper devices which are disposed on a work side of the work roll pair and are arranged to grip the workpieces and at an associated stage (S1 to S4) to lead them through the rolling gap in a feed/return direction; and a repository arranged to temporarily support workpieces and in co-operation with the manipulator to transfer them to another gripper device, preferably the adjacent gripper device of the next-higher stage (S2 to S4); characterised in that the gripper devices are arranged to grip the workpieces at one end and to guide them to an associated stage (S1 to S4) via the rolling gap, wherein the workpieces are not gripped at the other end.
An article comprising inorganic nanoporous particles bound together by a non-foamed water dispersible polyurethane, the article comprising 75 volume percent or more inorganic nanoporous particles based on total article volume and having a density, determined according to ASTM D1622, of 0.14 grams per cubic centimeter or less and a thermal conductivity, determined according to ASTM C518, of 25 milliWatts per meter*Kelvin or less and having a thickness of at least 0.5 centimeters, wherein said inorganic nanoporous particles are particles that define pores within the particle that have an average cross sectional diameter, calculated according to the Brunauer-Emmett-Teller technique with desorption curve data collected using the method Barrett-Joyner-Henda, of less than one micron, and wherein said inorganic nanoporous particles are functionally free of organic components having latent covalent bonding reactivity and functional coatings over the outside of the particles and the article is functionally free of hollow non-porous particles, sheet silicates and clay minerals.
A spectrum management server, comprising: a communications interface over which communications with a secondary user of spectrum are made, the secondary user having a need for spectrum access to carry out wireless communications and the communications including receiving a spectrum access request from the secondary user; characterized by: a processor adapted to execute logical instructions to configure the spectrum management server to: determine a primary user that has a protected use area that overlaps with a secondary use area of the secondary user; determine a quantified predicted amount of interference that operation of the secondary user has on a primary channel of the primary user; authorize spectrum access to the primary channel of the primary user under interference rights if the quantified predicted amount of interference has less than a predetermined amount of effect on the primary channel of the primary user; and communicate the spectrum access to the secondary user. determine a primary user that has a protected use area that overlaps with a secondary use area of the secondary user; determine a quantified predicted amount of interference that operation of the secondary user has on a primary channel of the primary user; authorize spectrum access to the primary channel of the primary user under interference rights if the quantified predicted amount of interference has less than a predetermined amount of effect on the primary channel of the primary user; and communicate the spectrum access to the secondary user.
Handpiece for the phacoemulsification of an eye lens, comprising: - a needle with an aspiration line arranged therein for transporting aspiration fluid, and - at least one drive element for generating a longitudinal wave, characterized in that the drive element is arranged in such a way that the longitudinal wave is directly coupleable into the aspiration fluid. - a needle with an aspiration line arranged therein for transporting aspiration fluid, and - at least one drive element for generating a longitudinal wave, characterized in that the drive element is arranged in such a way that the longitudinal wave is directly coupleable into the aspiration fluid.
A variable stiffness distal extension for a blood pump system, the distal extension comprising: a flexible elongate body having a distal end and a proximal end, and an exterior wall extending between the distal and proximal ends, the body further configured with a first axial portion, a second axial portion, and a distal tip portion; wherein the second axial portion is distal of the first axial portion and is integrally formed with the first axial portion; the distal tip portion is distal of the second axial portion and is integrally formed with the second axial portion, and an outer diameter of the exterior wall decreases continuously from the proximal end to the distal end characterized in that an inner diameter of the distal extension continuously decreases between the proximal end of the first axial portion and the distal end of the first axial portion. a flexible elongate body having a distal end and a proximal end, and an exterior wall extending between the distal and proximal ends, the body further configured with a first axial portion, a second axial portion, and a distal tip portion; wherein the second axial portion is distal of the first axial portion and is integrally formed with the first axial portion; the distal tip portion is distal of the second axial portion and is integrally formed with the second axial portion, and an outer diameter of the exterior wall decreases continuously from the proximal end to the distal end characterized in that an inner diameter of the distal extension continuously decreases between the proximal end of the first axial portion and the distal end of the first axial portion.
A contactless power supply device comprising: a power receiving portion placed in a middle in a vehicle width direction at a front portion on a lower surface of a floor panel of a vehicle and installed in a position proximate to front wheels of the vehicle, the front wheels being configured for steering the vehicle; a power supply portion located in a parking space to supply electric power to the vehicle without contact through magnetic connection between the power supply portion and the power receiving portion; a battery placed on the floor panel; a wire harness for transmitting electric power from the battery to a motor unit placed in a front compartment of the vehicle, the wire harness passing above the power receiving portion and extending in a vehicle front-rear direction, and a tunnel portion in a middle of the floor panel in the vehicle width direction, the tunnel portion protruding toward an interior room and extending in the vehicle front-rear direction, wherein: the wire harness is arranged along an inside of the tunnel portion, and characterised by that the power receiving portion is elongated across a lower open portion of the tunnel portion. a power receiving portion placed in a middle in a vehicle width direction at a front portion on a lower surface of a floor panel of a vehicle and installed in a position proximate to front wheels of the vehicle, the front wheels being configured for steering the vehicle; a power supply portion located in a parking space to supply electric power to the vehicle without contact through magnetic connection between the power supply portion and the power receiving portion; a battery placed on the floor panel; a wire harness for transmitting electric power from the battery to a motor unit placed in a front compartment of the vehicle, the wire harness passing above the power receiving portion and extending in a vehicle front-rear direction, and a tunnel portion in a middle of the floor panel in the vehicle width direction, the tunnel portion protruding toward an interior room and extending in the vehicle front-rear direction, wherein: the wire harness is arranged along an inside of the tunnel portion, and characterised by that the power receiving portion is elongated across a lower open portion of the tunnel portion. the wire harness is arranged along an inside of the tunnel portion, and characterised by that the power receiving portion is elongated across a lower open portion of the tunnel portion.
A method for wireless communication at a first user equipment, LTE, comprising: establishing (610, 710) a signaling radio bearer, SRB, for a communication session with a second LTE on a first frequency band based on a radio resource control, RRC, connection; sending (620, 720), to the second UE over the SRB on the first frequency band, a first RRC message to establish a data radio bearer, DRB, for the communication session on a second frequency band; and configuring (630, 730) the DRB on the second frequency band wherein: the configuring is based on one or more parameters of a device-to-device discovery procedure performed with the second LTE over the first frequency band; or the first RRC message includes one or more parameters for establishing the DRB on the second frequency band and the configuring is based on the one or more parameters of the first RRC message. establishing (610, 710) a signaling radio bearer, SRB, for a communication session with a second LTE on a first frequency band based on a radio resource control, RRC, connection; sending (620, 720), to the second UE over the SRB on the first frequency band, a first RRC message to establish a data radio bearer, DRB, for the communication session on a second frequency band; and configuring (630, 730) the DRB on the second frequency band wherein: the configuring is based on one or more parameters of a device-to-device discovery procedure performed with the second LTE over the first frequency band; or the first RRC message includes one or more parameters for establishing the DRB on the second frequency band and the configuring is based on the one or more parameters of the first RRC message. the configuring is based on one or more parameters of a device-to-device discovery procedure performed with the second LTE over the first frequency band; or the first RRC message includes one or more parameters for establishing the DRB on the second frequency band and the configuring is based on the one or more parameters of the first RRC message.
A device for use in locally delivering and controllably releasing oxybutynin in the cervical region of a female for a period of up to 28 days, wherein the device comprises: a) a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer, and the ring has a sufficient size such that it can be inserted into a vaginal canal of the female; and b) a pharmaceutical composition comprising a therapeutically effective amount of oxybutynin and an excipient, wherein the pharmaceutical composition is inserted within the ring; such that upon insertion of the ring into the vaginal canal, a therapeutically effective amount of oxybutynin is controllably released from the ring for a period of up to 28 days. a) a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer, and the ring has a sufficient size such that it can be inserted into a vaginal canal of the female; and b) a pharmaceutical composition comprising a therapeutically effective amount of oxybutynin and an excipient, wherein the pharmaceutical composition is inserted within the ring;
Combination of a dispenser pump and a nozzle structure of a dispenser pump, the dispenser pump comprising a pump button with a discharging portion for thereby discharging contents to the outside, wherein the nozzle structure is engaged to the discharging portion and wherein the nozzle structure comprising an inner nozzle which is formed in a cylindrical shape engaged to the discharge portion and has a plurality of content inflow holes formed at an end portion of a rear surface and spaced apart at regular intervals, and a blocking rod which forwardly protrudes from the center of an end of the rear surface; an outer nozzle moveable backwards and forwards and the outer nozzle moves forward by pressure of the contents thereby opening a discharging hole and including: a cylindrical mounting part which is engaged surrounding surrounds the blocking rod and is mounted at an end of the inner side of the inner nozzle, and a front end and an end portion of the cylindrical mounting part are formed in a piston structure coming into contact with the end of the inner side of the inner nozzle; and a content movement tube which forwardly extends from the center of the front surface of the mounting part for thereby forming a passage through which the contents move and has a the discharge hole which is opened and closed by the blocking rod; an elastic member which surrounds the outer nozzle and is mounted at the mounting part and moves backwards the outer nozzle; and an elastic member fixing part which is engaged surrounding the outer nozzle and the elastic member and has an elastic member mounting shoulder at the front surface in the inward direction for thereby mounting the elastic member, and an engaging part at the rear surface, which is engaged at an inner side of the inner nozzle. a cylindrical mounting part which is engaged surrounding surrounds the blocking rod and is mounted at an end of the inner side of the inner nozzle, and a front end and an end portion of the cylindrical mounting part are formed in a piston structure coming into contact with the end of the inner side of the inner nozzle; and a content movement tube which forwardly extends from the center of the front surface of the mounting part for thereby forming a passage through which the contents move and has a the discharge hole which is opened and closed by the blocking rod;
An integrated circuit comprising: a circuit element formed from a material that is superconducting at temperatures less than one hundred milliKelvin; and a resistor connected to the circuit element, the resistor being formed from an alloy of transition metals that is resistive at temperatures less than one hundred milliKelvin, characterised by an atomic ratio of the transition metals within the alloy being selected such that a ratio of the number of valance electrons to atoms within the alloy is between 5.35 and 5.95. a circuit element formed from a material that is superconducting at temperatures less than one hundred milliKelvin; and a resistor connected to the circuit element, the resistor being formed from an alloy of transition metals that is resistive at temperatures less than one hundred milliKelvin, characterised by an atomic ratio of the transition metals within the alloy being selected such that a ratio of the number of valance electrons to atoms within the alloy is between 5.35 and 5.95.
System for suctioning braking particles from a friction braking system, the suction system comprising: at least one negative-pressure source, at least one suction mouth, connected by a pneumatic circuit to the negative-pressure source, and a control unit configured to control the negative-pressure source, characterized in that the suction system further comprises a device for determining the current airflow conditions prevailing in the pneumatic circuit, and in that the control unit controls the negative-pressure source so that the current airflow conditions in the pneumatic circuit reach or tend to meet a setpoint for the airflow conditions. at least one negative-pressure source, at least one suction mouth, connected by a pneumatic circuit to the negative-pressure source, and a control unit configured to control the negative-pressure source, characterized in that the suction system further comprises a device for determining the current airflow conditions prevailing in the pneumatic circuit, and in that the control unit controls the negative-pressure source so that the current airflow conditions in the pneumatic circuit reach or tend to meet a setpoint for the airflow conditions.
A method for producing water-absorbent resin particles comprising: adding an ethylenically unsaturated monomer all at once to a hydrocarbon dispersion medium mixed with a surfactant to perform reversed phase suspension polymerization, wherein the reversed phase suspension polymerization is performed in one step, or two or more steps, the surfactant is a polyoxyethylene alkyl ether phosphate sodium salt, and the surfactant has an HLB of 9 to 15. adding an ethylenically unsaturated monomer all at once to a hydrocarbon dispersion medium mixed with a surfactant to perform reversed phase suspension polymerization, wherein the reversed phase suspension polymerization is performed in one step, or two or more steps, the surfactant is a polyoxyethylene alkyl ether phosphate sodium salt, and the surfactant has an HLB of 9 to 15.