An Fc construct for use in a method of therapy for inducing immune cell activation of the immune response in a subject, the Fc construct comprising: a) a first polypeptide having the formula A-L1-B-L2-C; wherein i) A comprises a first Fc domain monomer; ii) L1 is a linker; iii) B comprises a second Fc domain monomer; iv) L2 is a linker; and v) C comprises a third Fc domain monomer; b) a second polypeptide having the formula A'-L1'-B'-L2'-C'; wherein i) A' comprises a fourth Fc domain monomer; ii) L1' is a linker; iii) B' comprises a fifth Fc domain monomer; iv) L2' is a linker; and v) C' comprises a sixth Fc domain monomer; c) a third polypeptide that comprises a seventh Fc domain monomer; d) a fourth polypeptide that comprises an eighth Fc domain monomer; e) a fifth polypeptide that comprises a ninth Fc domain monomer; and f) a sixth polypeptide that comprises a tenth Fc domain monomer; wherein A and said seventh Fc domain monomer combine to form a first Fc domain, B and B' combine to form a second Fc domain, C and said eighth Fc domain monomer combine to form a third Fc domain, A' and said ninth Fc domain monomer combine to form a fourth Fc domain, and C' and said tenth Fc domain monomer combine to form a fifth Fc domain; wherein each of said first and seventh Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said first Fc domain monomer and said seventh Fc domain monomer, each of said second and fifth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said second Fc domain monomer and said fifth Fc domain monomer, each of said third and eighth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said third Fc domain monomer and said eighth Fc domain monomer; each of said fourth and ninth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said fourth Fc domain monomer and said ninth Fc domain monomer; each of said sixth and tenth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said sixth Fc domain monomer and said tenth Fc domain monomer; and wherein each of said Fc domain monomers is an IgG1 Fc domain monomer. a) a first polypeptide having the formula A-L1-B-L2-C; wherein i) A comprises a first Fc domain monomer; ii) L1 is a linker; iii) B comprises a second Fc domain monomer; iv) L2 is a linker; and v) C comprises a third Fc domain monomer; i) A comprises a first Fc domain monomer; ii) L1 is a linker; iii) B comprises a second Fc domain monomer; iv) L2 is a linker; and v) C comprises a third Fc domain monomer; b) a second polypeptide having the formula A'-L1'-B'-L2'-C'; wherein i) A' comprises a fourth Fc domain monomer; ii) L1' is a linker; iii) B' comprises a fifth Fc domain monomer; iv) L2' is a linker; and v) C' comprises a sixth Fc domain monomer; i) A' comprises a fourth Fc domain monomer; ii) L1' is a linker; iii) B' comprises a fifth Fc domain monomer; iv) L2' is a linker; and v) C' comprises a sixth Fc domain monomer; c) a third polypeptide that comprises a seventh Fc domain monomer; d) a fourth polypeptide that comprises an eighth Fc domain monomer; e) a fifth polypeptide that comprises a ninth Fc domain monomer; and f) a sixth polypeptide that comprises a tenth Fc domain monomer; wherein A and said seventh Fc domain monomer combine to form a first Fc domain, B and B' combine to form a second Fc domain, C and said eighth Fc domain monomer combine to form a third Fc domain, A' and said ninth Fc domain monomer combine to form a fourth Fc domain, and C' and said tenth Fc domain monomer combine to form a fifth Fc domain; wherein each of said first and seventh Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said first Fc domain monomer and said seventh Fc domain monomer, each of said second and fifth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said second Fc domain monomer and said fifth Fc domain monomer, each of said third and eighth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said third Fc domain monomer and said eighth Fc domain monomer; each of said fourth and ninth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said fourth Fc domain monomer and said ninth Fc domain monomer; each of said sixth and tenth Fc domain monomers comprises a complementary dimerization selectivity module that promotes dimerization between said sixth Fc domain monomer and said tenth Fc domain monomer; and wherein each of said Fc domain monomers is an IgG1 Fc domain monomer.