mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a gRNA molecule comprising a targeting domain which is complementary with a target domain from a gene expressed in a eukaryotic cell, wherein the gRNA molecule: (a) comprises a 3' poly A tail; and (b) is complexed with a Cas9 protein. (a) comprises a 3' poly A tail; and (b) is complexed with a Cas9 protein.
A system-on-chip, SoC, comprising: an image processing circuit comprising: a first memory that is configured to store a radial look-up table, LUT,, a set of tangential LUTs, and co-ordinates of a correction center of a distorted image, wherein the radial LUT includes a first set of parameters to correct radial distortion of the distorted image, and the set of tangential LUTs includes a second set of parameters to correct tangential distortion of the distorted image; and a correction circuit that is coupled with the first memory, and is configured to: (i) generate a set of correction LUT portions based on the radial LUT, the set of tangential LUTs, and the co-ordinates of the correction center, and (ii) correct a set of distorted image portions of the distorted image based on the generated set of correction LUT portions to generate a set of corrected image portions of a corrected image. a first memory that is configured to store a radial look-up table, LUT,, a set of tangential LUTs, and co-ordinates of a correction center of a distorted image, wherein the radial LUT includes a first set of parameters to correct radial distortion of the distorted image, and the set of tangential LUTs includes a second set of parameters to correct tangential distortion of the distorted image; and a correction circuit that is coupled with the first memory, and is configured to: (i) generate a set of correction LUT portions based on the radial LUT, the set of tangential LUTs, and the co-ordinates of the correction center, and (ii) correct a set of distorted image portions of the distorted image based on the generated set of correction LUT portions to generate a set of corrected image portions of a corrected image. (i) generate a set of correction LUT portions based on the radial LUT, the set of tangential LUTs, and the co-ordinates of the correction center, and (ii) correct a set of distorted image portions of the distorted image based on the generated set of correction LUT portions to generate a set of corrected image portions of a corrected image.
A method for spin-coating a substrate having a structure, the method comprising: preparing the substrate having the structure of a predetermined height formed on an upper portion thereof; coating the structure of the substrate with photoresist; and performing spin-coating of the photoresist in a place in which a heat source is provided, while simultaneously performing pre-baking of the photoresist in the place. preparing the substrate having the structure of a predetermined height formed on an upper portion thereof; coating the structure of the substrate with photoresist; and performing spin-coating of the photoresist in a place in which a heat source is provided, while simultaneously performing pre-baking of the photoresist in the place.
Tensioning device for tensioning a tarpaulin at a lateral limitation of a load bed of a vehicle, comprising at least one tensioning element for generating a tension in the tarpaulin, wherein the tensioning element is configured to exert a tensile force on the tarpaulin such that the tarpaulin is tensioned in an extensive manner, wherein the tensioning device can be undetachably fixed, by means of at least one fixing element, in the region of the lateral limitation of the load bed, and at least one free coupling element for connection to the tarpaulin is formed, wherein the coupling element is connected to the tensioning element by means of a connection element, at at least one connection point, wherein the position of the connection point relative to the fixing element is variable by means of the tensioning element, such that tensioning of the couplable tarpaulin is achieved by changing the position of the connection point, characterised in that the connection element at least partially surrounds the tensioning element in a sleeve-like manner, wherein the tensioning element is configured so as to be reversibly expandable.
A stator for a helical gear device, comprising: a plurality of rigid disks stacked together and defining a helically convoluted elongated chamber, each of said rigid disks having an interior surface with radially extending lobes defining a central aperture, said rigid disks being concentrically aligned face-to-face in a stacked helical relationship with one another with each disk rotated with respect to an adjacent one of said rigid disks progressively along a length of said disk stack in one direction of rotation to define a helically convoluted elongated chamber; a bonding member fixedly attached to said rigid disks to bond said rigid disks together as said disk stack; and a plurality of rigid support rings fixedly attached to said disk stack, said rings including a first ring and a second ring, said first and second rings fitted concentrically at opposite ends of said disk stack against the end rigid disks of said disk stack, said rings being sized with an inside diameter substantially equal to the major diameter of the central aperture defined by the radially extending lobes of said rigid disks and said rings supporting a rotor nutatively disposed in said helically convoluted elongated chamber by contact with the rotor, characterized in that said support rings having an axial width that is greater than an axial width of each of said rigid disks, and said bonding member including a tube, said tube housing said disk stack and said rigid support rings entirely within said tube. a plurality of rigid disks stacked together and defining a helically convoluted elongated chamber, each of said rigid disks having an interior surface with radially extending lobes defining a central aperture, said rigid disks being concentrically aligned face-to-face in a stacked helical relationship with one another with each disk rotated with respect to an adjacent one of said rigid disks progressively along a length of said disk stack in one direction of rotation to define a helically convoluted elongated chamber; a bonding member fixedly attached to said rigid disks to bond said rigid disks together as said disk stack; and a plurality of rigid support rings fixedly attached to said disk stack, said rings including a first ring and a second ring, said first and second rings fitted concentrically at opposite ends of said disk stack against the end rigid disks of said disk stack, said rings being sized with an inside diameter substantially equal to the major diameter of the central aperture defined by the radially extending lobes of said rigid disks and said rings supporting a rotor nutatively disposed in said helically convoluted elongated chamber by contact with the rotor, characterized in that said support rings having an axial width that is greater than an axial width of each of said rigid disks, and said bonding member including a tube, said tube housing said disk stack and said rigid support rings entirely within said tube.
A printer comprising: a print frame; a print head fixed relative to the print frame; a platen drive gear rotatably mounted to the print frame; and a platen assembly pivotally mounted to the print frame, the platen assembly including a platen rotatably driven by a platen gear coaxial with the platen and meshing with the platen drive gear, the platen assembly being pivotable about an axis offset from an axis of rotation of the platen drive gear characterized in that the axis about which the platen assembly is pivotable extends through an area of meshing of the platen drive gear and the platen gear. a print frame; a print head fixed relative to the print frame; a platen drive gear rotatably mounted to the print frame; and a platen assembly pivotally mounted to the print frame, the platen assembly including a platen rotatably driven by a platen gear coaxial with the platen and meshing with the platen drive gear, the platen assembly being pivotable about an axis offset from an axis of rotation of the platen drive gear characterized in that the axis about which the platen assembly is pivotable extends through an area of meshing of the platen drive gear and the platen gear.
Cosmetic use of a composition comprising exosomes derived from rose stem cells as an active ingredient for skin regeneration, skin elasticity improvement or skin wrinkle reduction.
Offshore gravity based structure comprising a plurality of storage cells resting fixedly on the seabed and grouped around at least one foot emerging above sea level and supporting a platform comprising equipment allowing the introduction and the extraction of a fluid in at least one of the cells of the said plurality of storage cells, characterized in that the fluid is hydrogen and in that the equipment further comprises at least one compression/decompression assembly for supplying hydrogen via a transfer pipe to a determined pressure compatible with its storage in said at least one of the cells and draining it, said at least one of the cells having been previously provided with a rigid (110; 110A, 110B, 110C, 110D) or deformable internal envelope covered, lined or formed of a material inert with respect to hydrogen.
A method for manufacturing an SOI wafer comprising the steps of: implanting at least one gas ion of a hydrogen ion and a rare gas ion into a silicon single crystal bond wafer from a surface thereof to form an ion implanted layer; bonding the ion-implanted surface of the bond wafer to a surface of a base wafer through an insulator film; and delaminating the bond wafer at the ion-implanted layer to manufacture the SOI wafer, the method further comprising the step of immersing the bonded wafer prior to the delamination of the bond wafer at the ion-implanted layer into a liquid capable of dissolving the insulator film or exposing the bonded wafer to a gas capable of dissolving the insulator film, characterised in that the insulator film located between the bond wafer and the base wafer is etched in the range of not less than 0.5 mm and not more than 10 mm from an outer circumferential edge toward a center of the bonded wafer. implanting at least one gas ion of a hydrogen ion and a rare gas ion into a silicon single crystal bond wafer from a surface thereof to form an ion implanted layer; bonding the ion-implanted surface of the bond wafer to a surface of a base wafer through an insulator film; and delaminating the bond wafer at the ion-implanted layer to manufacture the SOI wafer, the method further comprising the step of immersing the bonded wafer prior to the delamination of the bond wafer at the ion-implanted layer into a liquid capable of dissolving the insulator film or exposing the bonded wafer to a gas capable of dissolving the insulator film, characterised in that the insulator film located between the bond wafer and the base wafer is etched in the range of not less than 0.5 mm and not more than 10 mm from an outer circumferential edge toward a center of the bonded wafer.
Collision sensing device, preferably for a water jet cutting device, adapted to detect a collision between two or more objects, wherein said collision sensing device comprises a deformable member of elastically deformable material which upper side defines a space that can be assigned a pressure, which deformable member in a first condition is undeformed whereby the space is assigned a first pressure, and wherein in a second condition the deformable member is deformed whereby the space is assigned a second pressure, wherein the deformable member, upon collision of the deformable member with an object, is deformed into the second condition whereby the pressure in the space changes from the first pressure to the second pressure, and a means for detecting the pressure change, characterised in that the deformable member is a splatter shield which has the form of a frustum of a cone, wherein the space is further defined by a bulge enclosing the upper side of the splatter shield and also a support plate which is sealingly arranged against the bulge.
An apparatus for steam reforming of hydrocarbons comprising a steam reformer containing a plurality of externally-heated vertical tubes each tube having an inlet for a feed gas mixture comprising hydrocarbon and steam, and an outlet for a reformed gas mixture, wherein the tubes contain a particulate steam reforming catalyst comprising nickel adjacent the outlet and a structured steam reforming catalyst comprising nickel adjacent the inlet, wherein the structured steam reforming catalyst is a steam reforming catalyst supported on a structure or is a steam reforming catalyst contained within a structure.
Dredging device (1, 2, 3) comprising: - a dredging vessel adapted for movement in a direction of movement; - a dredge suction head connected to the dredging vessel and having a dredge suction opening; - a dredge pump placed on the dredging vessel and having a suction connection; - a suction conduit connecting the dredge suction head to the suction connection of the dredge pump; - support means (4, 5) placed between the dredging vessel and the dredge suction head for supporting the dredge suction conduit, the support means (4, 5) being adapted to determine the depth of the dredge suction head, - wherein the dredging vessel comprises a measuring device for measuring the distance between the dredge suction head and the bottom, characterised by a control device adapted to control the support means (4, 5) for the purpose of holding the dredge suction head at a distance from the bottom of the basin for dredging, - wherein edges of the dredge suction opening of the dredge suction head that can come into contact with the bottom are provided as smooth edges with a rounded cross-section, and - wherein the ratio of the surface area of the dredge suction opening to the periphery thereof lies between 0.03 m and 0.25 m. - a dredging vessel adapted for movement in a direction of movement; - a dredge suction head connected to the dredging vessel and having a dredge suction opening; - a dredge pump placed on the dredging vessel and having a suction connection; - a suction conduit connecting the dredge suction head to the suction connection of the dredge pump; - support means (4, 5) placed between the dredging vessel and the dredge suction head for supporting the dredge suction conduit, the support means (4, 5) being adapted to determine the depth of the dredge suction head, - wherein the dredging vessel comprises a measuring device for measuring the distance between the dredge suction head and the bottom, characterised by a control device adapted to control the support means (4, 5) for the purpose of holding the dredge suction head at a distance from the bottom of the basin for dredging, - wherein edges of the dredge suction opening of the dredge suction head that can come into contact with the bottom are provided as smooth edges with a rounded cross-section, and - wherein the ratio of the surface area of the dredge suction opening to the periphery thereof lies between 0.03 m and 0.25 m.
A multi-dose ophthalmic composition, comprising: brinzolamide, brimonidine or a combination thereof as therapeutic agent; a first polyol, the first polyol being selected from mannitol, sorbitol or a combination thereof, the concentration of the first polyol being at least 0.01 w/v% but no greater than 0.5 w/v%; a second polyol, the second polyol being selected from propylene glycol, glycerine or a combination thereof, the concentration of the second polyol being at least 0.1 w/v% but less than 5 w/v% of the composition; an effective amount of borate, the effective amount being at least 0.05 w/v% and less than 0.5 w/v% of the overall composition; BAC as an anti-microbial preservative, the concentration of BAC in the composition being greater than 0.00001 w/v% but less than 0.0035 w/v%; and water. brinzolamide, brimonidine or a combination thereof as therapeutic agent; a first polyol, the first polyol being selected from mannitol, sorbitol or a combination thereof, the concentration of the first polyol being at least 0.01 w/v% but no greater than 0.5 w/v%; a second polyol, the second polyol being selected from propylene glycol, glycerine or a combination thereof, the concentration of the second polyol being at least 0.1 w/v% but less than 5 w/v% of the composition; an effective amount of borate, the effective amount being at least 0.05 w/v% and less than 0.5 w/v% of the overall composition; BAC as an anti-microbial preservative, the concentration of BAC in the composition being greater than 0.00001 w/v% but less than 0.0035 w/v%; and water.
A buck converter (2000, 3000) comprising: a buck converter output (220,322) for outputting an output supply voltage; a drive controller (210, 316); a detector (214, 318) connected to the drive controller and the buck converter output and operable to output a signal to the drive controller in response to a desired output voltage on the buck converter output; a first power supply domain (206, 306) operably coupled to a power source; a second power supply domain (208, 308) coupled to the drive controller; a power supply controller (224, 380) comprising a first voltage regulator (200, 302) having a first voltage regulator input coupled to the first power supply domain and a first voltage regulator output coupled to the second power supply domain; a second voltage regulator (202, 304) having a second voltage regulator input coupled to the buck converter output, a second voltage regulator output, and a switch (212, 310) arranged between the second voltage regulator output and the second power supply domain; wherein the switch is coupled to the drive controller and wherein the power supply controller is operable to switchably couple the buck converter output to the second power supply domain in response to the buck converter output stabilizing and wherein the first voltage regulator is configured to output a regulated voltage value which is less than the regulated voltage value from the second voltage regulator. a buck converter output (220,322) for outputting an output supply voltage; a drive controller (210, 316); a detector (214, 318) connected to the drive controller and the buck converter output and operable to output a signal to the drive controller in response to a desired output voltage on the buck converter output; a first power supply domain (206, 306) operably coupled to a power source; a second power supply domain (208, 308) coupled to the drive controller; a power supply controller (224, 380) comprising a first voltage regulator (200, 302) having a first voltage regulator input coupled to the first power supply domain and a first voltage regulator output coupled to the second power supply domain; a second voltage regulator (202, 304) having a second voltage regulator input coupled to the buck converter output, a second voltage regulator output, and a switch (212, 310) arranged between the second voltage regulator output and the second power supply domain; wherein the switch is coupled to the drive controller and wherein the power supply controller is operable to switchably couple the buck converter output to the second power supply domain in response to the buck converter output stabilizing and wherein the first voltage regulator is configured to output a regulated voltage value which is less than the regulated voltage value from the second voltage regulator.
A combined imaging system comprising: a first imaging system configured to acquire structural data of at least one anatomical structure in a first field-of-view; a first imaging system reconstruction processor which reconstructs the acquired structural data from the first imaging system into a first system image representation; a nuclear imaging system configured to acquire functional data of at least one anatomical structure in a second FOV, the second FOV being smaller than the first FOV; a nuclear image reconstruction processor which reconstructs a nuclear image representation from the functional data acquired by the nuclear imaging system; characterised in that the combined imaging system has: an anatomy extraction unit which extracts from the first system image representation a map including at least a portion of at least one anatomical structure excluded from the second FOV and included in the first FOV; and a fusion processor which combines the nuclear image representation and the map to generate an extended FOV image representation having nuclear image intensity values extrapolated from the nuclear image representation to include at least a portion of at least one anatomical structure excluded from the second FOV and included in the first FOV; and a reconstruction processor configured to receive the extended FOV image representation and to reconstruct the functional data acquired by the nuclear imaging system based on the structural data acquired by the first imaging system, wherein the functional data is corrected for at least one of spill-over and backscatter artifacts based on the structural data. a first imaging system configured to acquire structural data of at least one anatomical structure in a first field-of-view; a first imaging system reconstruction processor which reconstructs the acquired structural data from the first imaging system into a first system image representation; a nuclear imaging system configured to acquire functional data of at least one anatomical structure in a second FOV, the second FOV being smaller than the first FOV; a nuclear image reconstruction processor which reconstructs a nuclear image representation from the functional data acquired by the nuclear imaging system; an anatomy extraction unit which extracts from the first system image representation a map including at least a portion of at least one anatomical structure excluded from the second FOV and included in the first FOV; and a fusion processor which combines the nuclear image representation and the map to generate an extended FOV image representation having nuclear image intensity values extrapolated from the nuclear image representation to include at least a portion of at least one anatomical structure excluded from the second FOV and included in the first FOV; and a reconstruction processor configured to receive the extended FOV image representation and to reconstruct the functional data acquired by the nuclear imaging system based on the structural data acquired by the first imaging system, wherein the functional data is corrected for at least one of spill-over and backscatter artifacts based on the structural data.