A medical device for treating a bodily passage having a wall, said medical device comprising: an elongate member having an elongate member proximal end, an elongate member distal end, and a lengthwise axis, the elongate member defining an infusion lumen and an inflation lumen; a first balloon attached to the elongate member and adapted to move between a deflated configuration and an inflated configuration, the first balloon comprising a first balloon wall defining an infusion chamber and at least one protuberance extending radially outward from the first balloon wall, the at least one protuberance having a protuberance height, a protuberance length, and a protuberance outer surface, the infusion chamber in communication with the infusion lumen, the at least one protuberance defining a plurality of protuberance pores in communication with the infusion chamber such that fluid introduced into the infusion chamber can pass through each protuberance pore of the plurality of protuberance pores, each pore of the plurality of protuberance pores having an opening defined on the protuberance outer surface; and a second balloon attached to the elongate member and disposed radially inward of the first balloon, the second balloon adapted to move between a deflated configuration and an inflated configuration and comprising a second balloon wall defining an inflation chamber in communication with the inflation lumen; the at least one protuberance extending radially outward from the first balloon wall to the protuberance outer surface, and each protuberance pore of the plurality of protuberance pores extending through the protuberance height; wherein the protuberance outer surface is adapted to damage said wall of said bodily passage when the second balloon is in the inflated configuration; and wherein the plurality of protuberance pores is arranged along the protuberance length of the at least one protuberance relative to the lengthwise axis of the elongate member. an elongate member having an elongate member proximal end, an elongate member distal end, and a lengthwise axis, the elongate member defining an infusion lumen and an inflation lumen; a first balloon attached to the elongate member and adapted to move between a deflated configuration and an inflated configuration, the first balloon comprising a first balloon wall defining an infusion chamber and at least one protuberance extending radially outward from the first balloon wall, the at least one protuberance having a protuberance height, a protuberance length, and a protuberance outer surface, the infusion chamber in communication with the infusion lumen, the at least one protuberance defining a plurality of protuberance pores in communication with the infusion chamber such that fluid introduced into the infusion chamber can pass through each protuberance pore of the plurality of protuberance pores, each pore of the plurality of protuberance pores having an opening defined on the protuberance outer surface; and a second balloon attached to the elongate member and disposed radially inward of the first balloon, the second balloon adapted to move between a deflated configuration and an inflated configuration and comprising a second balloon wall defining an inflation chamber in communication with the inflation lumen; the at least one protuberance extending radially outward from the first balloon wall to the protuberance outer surface, and each protuberance pore of the plurality of protuberance pores extending through the protuberance height; wherein the protuberance outer surface is adapted to damage said wall of said bodily passage when the second balloon is in the inflated configuration; and wherein the plurality of protuberance pores is arranged along the protuberance length of the at least one protuberance relative to the lengthwise axis of the elongate member.