An interference signal cancellation apparatus, comprising: a first power divider, configured to divide a cancellation reference signal link corresponding to a transmit antenna into a first reference link and a second reference link; a second power divider, configured to: divide a signal receiving link connected to a receive antenna into a first receiving link and a second receiving link, and use the first receiving link as an output link; a primary cancellation unit located at the first reference link, connected to the signal receiving link by using a coupler, and configured to: receive a primary configuration parameter of a control module, and perform interference cancellation processing on a received signal on the signal receiving link according to the primary configuration parameter and a cancellation reference signal on the first reference link, to generate a first signal without interference that is transmitted on the signal receiving link; a secondary cancellation unit located at the second reference link, connected to the second receiving link by using a coupler, and configured to: receive a secondary configuration parameter of the control module, and perform interference cancellation processing on a received signal on the second receiving link according to the secondary configuration parameter and a cancellation reference signal on the second reference link, to generate a second signal without interference that is transmitted on the second receiving link; and the control module, connected to the second receiving link, the primary cancellation unit, and the secondary cancellation unit, and configured to: generate the secondary configuration parameter; detect, after sending the secondary configuration parameter to the secondary cancellation unit, a power value of the second signal without interference and a power value of the first signal without interference; determine, according to the power value of the second signal without interference and the power value of the first signal without interference, whether the secondary cancellation unit can decrease the power value of the first signal without interference; if yes, generate an updated primary configuration parameter according to the secondary configuration parameter of the secondary cancellation unit and the primary configuration parameter of the primary cancellation unit; and send the updated primary configuration parameter to the primary cancellation unit. a first power divider, configured to divide a cancellation reference signal link corresponding to a transmit antenna into a first reference link and a second reference link; a second power divider, configured to: divide a signal receiving link connected to a receive antenna into a first receiving link and a second receiving link, and use the first receiving link as an output link; a primary cancellation unit located at the first reference link, connected to the signal receiving link by using a coupler, and configured to: receive a primary configuration parameter of a control module, and perform interference cancellation processing on a received signal on the signal receiving link according to the primary configuration parameter and a cancellation reference signal on the first reference link, to generate a first signal without interference that is transmitted on the signal receiving link; a secondary cancellation unit located at the second reference link, connected to the second receiving link by using a coupler, and configured to: receive a secondary configuration parameter of the control module, and perform interference cancellation processing on a received signal on the second receiving link according to the secondary configuration parameter and a cancellation reference signal on the second reference link, to generate a second signal without interference that is transmitted on the second receiving link; and the control module, connected to the second receiving link, the primary cancellation unit, and the secondary cancellation unit, and configured to: generate the secondary configuration parameter; detect, after sending the secondary configuration parameter to the secondary cancellation unit, a power value of the second signal without interference and a power value of the first signal without interference; determine, according to the power value of the second signal without interference and the power value of the first signal without interference, whether the secondary cancellation unit can decrease the power value of the first signal without interference; if yes, generate an updated primary configuration parameter according to the secondary configuration parameter of the secondary cancellation unit and the primary configuration parameter of the primary cancellation unit; and send the updated primary configuration parameter to the primary cancellation unit.