A composition comprising: (a) an activin receptor-like kinase 5 inhibitor; (b) a MAP/ERK kinase inhibitor; and (c) a Rho kinase (ROCK) inhibitor, wherein the ROCK inhibitor has the structure: wherein, L 2 is substituted or unsubstituted C 1 -C 10 alkylene; y is an integer from 0 to 3; z is an integer from 0 to 5; X is -N=, -CH= or -CR 5 =; R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3, R 4 and R 5 are independently -CN, -S n R 6, -NR 7 R 8, -C R 9, -NR 10 -C R 11, -NR 12 -C -OR 13, -C NR 14 R 15, -NR 16 S 2 R 17, -OR 18, -S 2 NR 19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 R 7, R 8, R 9, R 10, R 11, R 12, R 13, R 14, R 15, R 16, R 17, R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or a racemate, diastereomer, tautomer, or a geometric isomer thereof, or a pharmaceutically acceptable salt thereof. (a) an activin receptor-like kinase 5 inhibitor; (b) a MAP/ERK kinase inhibitor; and (c) a Rho kinase (ROCK) inhibitor, wherein the ROCK inhibitor has the structure: wherein, L 2 is substituted or unsubstituted C 1 -C 10 alkylene; y is an integer from 0 to 3; z is an integer from 0 to 5; X is -N=, -CH= or -CR 5 =; R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3, R 4 and R 5 are independently -CN, -S n R 6, -NR 7 R 8, -C R 9, -NR 10 -C R 11, -NR 12 -C -OR 13, -C NR 14 R 15, -NR 16 S 2 R 17, -OR 18, -S 2 NR 19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 R 7, R 8, R 9, R 10, R 11, R 12, R 13, R 14, R 15, R 16, R 17, R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 2 is substituted or unsubstituted C 1 -C 10 alkylene; y is an integer from 0 to 3; z is an integer from 0 to 5; X is -N=, -CH= or -CR 5 =; R 1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3, R 4 and R 5 are independently -CN, -S n R 6, -NR 7 R 8, -C R 9, -NR 10 -C R 11, -NR 12 -C -OR 13, -C NR 14 R 15, -NR 16 S 2 R 17, -OR 18, -S 2 NR 19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 R 7, R 8, R 9, R 10, R 11, R 12, R 13, R 14, R 15, R 16, R 17, R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;