An x-ray and gamma-ray radiation energy imaging device comprising: a detector substrate, the detector substrate having an electrode surface and a pixel surface opposite to the electrode surface, the detector substrate being disposed to convert said radiation energy impinging on the electrode surface to electrical charges, with the electrode surface having a continuous contact electrode disposed thereon, and with the pixel surface having a plurality of pixel collector electrodes disposed thereon and associated pixel contacts provided on the corresponding pixel collector electrodes with the pixel collector electrodes for collecting the electrical charges and forming a pixel pattern and the pixel contacts disposed in a pixel contact pattern; an ASIC readout substrate comprising a plurality of pixel circuits and having a readout surface disposed facing the pixel surface of the detector substrate, the pixel circuits each having an electrical transmission contact processed on the readout surface in a transmission contact pattern, the transmission contacts being inputs to pixel circuits of the ASIC readout substrate, and a plurality of electrical I/O contacts provided on the readout surface in an I/O contact pattern, the I/O contacts being the input and output electrical contacts for the ASIC readout substrate; an intermediate substrate disposed between the detector substrate and the ASIC readout substrate, and having an entry face adjacent the pixel surface and an exit face adjacent the readout surface, a plurality of discrete conductive via passages, the passages having a first end at the entry face disposed in an entry passage pattern corresponding to the pixel pattern and a second end at the exit face disposed in an exit passage pattern corresponding to the transmission contact pattern; and electrically conductive bonds discretely connecting each pixel contact in the pixel pattern to the first end of the corresponding conductive via passage of the entry passage pattern, and connecting each transmission contact in the transmission contact pattern to the second end of the corresponding conductive via passage of the exit passage pattern, and connecting each I/0 contact in the I/0 contact pattern with the corresponding wire contact in the wire contact pattern on the intermediate substrate, characterized in that the intermediate substrate has a plurality of wire contacts on the exit face disposed in a wire contact pattern corresponding to the I/O contact pattern on the readout surface, the wire contacts being in electrical communication with wire bonding pads mounted on a peripheral edge of the intermediate substrate. a detector substrate, the detector substrate having an electrode surface and a pixel surface opposite to the electrode surface, the detector substrate being disposed to convert said radiation energy impinging on the electrode surface to electrical charges, with the electrode surface having a continuous contact electrode disposed thereon, and with the pixel surface having a plurality of pixel collector electrodes disposed thereon and associated pixel contacts provided on the corresponding pixel collector electrodes with the pixel collector electrodes for collecting the electrical charges and forming a pixel pattern and the pixel contacts disposed in a pixel contact pattern; an ASIC readout substrate comprising a plurality of pixel circuits and having a readout surface disposed facing the pixel surface of the detector substrate, the pixel circuits each having an electrical transmission contact processed on the readout surface in a transmission contact pattern, the transmission contacts being inputs to pixel circuits of the ASIC readout substrate, and a plurality of electrical I/O contacts provided on the readout surface in an I/O contact pattern, the I/O contacts being the input and output electrical contacts for the ASIC readout substrate; an intermediate substrate disposed between the detector substrate and the ASIC readout substrate, and having an entry face adjacent the pixel surface and an exit face adjacent the readout surface, a plurality of discrete conductive via passages, the passages having a first end at the entry face disposed in an entry passage pattern corresponding to the pixel pattern and a second end at the exit face disposed in an exit passage pattern corresponding to the transmission contact pattern; and electrically conductive bonds discretely connecting each pixel contact in the pixel pattern to the first end of the corresponding conductive via passage of the entry passage pattern, and connecting each transmission contact in the transmission contact pattern to the second end of the corresponding conductive via passage of the exit passage pattern, and connecting each I/0 contact in the I/0 contact pattern with the corresponding wire contact in the wire contact pattern on the intermediate substrate, characterized in that the intermediate substrate has a plurality of wire contacts on the exit face disposed in a wire contact pattern corresponding to the I/O contact pattern on the readout surface, the wire contacts being in electrical communication with wire bonding pads mounted on a peripheral edge of the intermediate substrate.