A chimeric protein comprising: (i) a first polypeptide chain which comprises: (a) a Factor VIII (FVIII) protein comprising a N-terminal portion and a C-terminal portion; wherein the N-terminal portion of the FVIII protein comprises the A1 domain, A2 domain, and a portion of the B domain of full length mature FVIII (SEQ ID NO: 65); such that the N-terminal portion comprises the amino acid sequence of residues 1 to 745 of SEQ ID NO: 65 fused to a first XTEN sequence inserted immediately downstream of amino acid 745 of SEQ ID NO: 65; and wherein the C-terminal portion comprises the A3 domain, the C1 domain, and the C2 domain; (b) a first Fc region; and (ii) a second polypeptide chain which comprises, from the N-terminus to the C-terminus thereof: (a) a von Willebrand Factor fragment comprising a D' domain and a D3 domain of VWF, with an amino acid substitution at each of the residues 1099 and 1142 of SEQ ID NO: 21; (b) a second XTEN sequence, wherein the second XTEN sequence contains less than 288 amino acid residues; (c) a cleavable linker comprising an a2 region of FVIII which comprises the amino acid sequence of Glu720 to Arg740 corresponding to SEQ ID NO: 65, wherein the a2 region is capable of being cleaved by thrombin; and (d) a second Fc region, wherein the first Fc region is linked to or associated with the second Fc region. (i) a first polypeptide chain which comprises: (a) a Factor VIII (FVIII) protein comprising a N-terminal portion and a C-terminal portion; wherein the N-terminal portion of the FVIII protein comprises the A1 domain, A2 domain, and a portion of the B domain of full length mature FVIII (SEQ ID NO: 65); such that the N-terminal portion comprises the amino acid sequence of residues 1 to 745 of SEQ ID NO: 65 fused to a first XTEN sequence inserted immediately downstream of amino acid 745 of SEQ ID NO: 65; and wherein the C-terminal portion comprises the A3 domain, the C1 domain, and the C2 domain; (b) a first Fc region; and (a) a Factor VIII (FVIII) protein comprising a N-terminal portion and a C-terminal portion; wherein the N-terminal portion of the FVIII protein comprises the A1 domain, A2 domain, and a portion of the B domain of full length mature FVIII (SEQ ID NO: 65); such that the N-terminal portion comprises the amino acid sequence of residues 1 to 745 of SEQ ID NO: 65 fused to a first XTEN sequence inserted immediately downstream of amino acid 745 of SEQ ID NO: 65; and wherein the C-terminal portion comprises the A3 domain, the C1 domain, and the C2 domain; wherein the N-terminal portion of the FVIII protein comprises the A1 domain, A2 domain, and a portion of the B domain of full length mature FVIII (SEQ ID NO: 65); such that the N-terminal portion comprises the amino acid sequence of residues 1 to 745 of SEQ ID NO: 65 fused to a first XTEN sequence inserted immediately downstream of amino acid 745 of SEQ ID NO: 65; and wherein the C-terminal portion comprises the A3 domain, the C1 domain, and the C2 domain; (b) a first Fc region; and (ii) a second polypeptide chain which comprises, from the N-terminus to the C-terminus thereof: (a) a von Willebrand Factor fragment comprising a D' domain and a D3 domain of VWF, with an amino acid substitution at each of the residues 1099 and 1142 of SEQ ID NO: 21; (b) a second XTEN sequence, wherein the second XTEN sequence contains less than 288 amino acid residues; (c) a cleavable linker comprising an a2 region of FVIII which comprises the amino acid sequence of Glu720 to Arg740 corresponding to SEQ ID NO: 65, wherein the a2 region is capable of being cleaved by thrombin; and (d) a second Fc region, (a) a von Willebrand Factor fragment comprising a D' domain and a D3 domain of VWF, with an amino acid substitution at each of the residues 1099 and 1142 of SEQ ID NO: 21; (b) a second XTEN sequence, wherein the second XTEN sequence contains less than 288 amino acid residues; (c) a cleavable linker comprising an a2 region of FVIII which comprises the amino acid sequence of Glu720 to Arg740 corresponding to SEQ ID NO: 65, wherein the a2 region is capable of being cleaved by thrombin; and (d) a second Fc region,