mhurhangee/ep-ind-claims huggingface dataset:
Bicycles tyre, comprising a pair of bead cores, a carcass structure turned around the pair of bead cores and a tread band radially outer to the carcass structure; at each bead core being provided: an elastomeric material filler, which extends in a radial direction for a first length starting from the bead core, a loop interposed between the carcass structure and the elastomeric material filler, turned around the bead core so as to define a first flap axially outer to the elastomeric material filler and a second flap axially inner to the elastomeric material filler, wherein the first flap extends in a radial direction for a second length starting from the bead core, and the second flap extends in a radial direction for a third length starting from the bead core; wherein the second and third lengths are less than or equal to the first length. an elastomeric material filler, which extends in a radial direction for a first length starting from the bead core, a loop interposed between the carcass structure and the elastomeric material filler, turned around the bead core so as to define a first flap axially outer to the elastomeric material filler and a second flap axially inner to the elastomeric material filler, wherein the first flap extends in a radial direction for a second length starting from the bead core, and the second flap extends in a radial direction for a third length starting from the bead core; wherein the second and third lengths are less than or equal to the first length.
Method for creating a database for the pre-assessment of the efficacy of a cytostatic active substance, which is a platinum derivative/platinum analogoue, in the chemotherapeutic treatment of a tumor, especially a malignant tumor, of a particular patient on the basis of ex vivo determination of the IC50 value of the active substance for the tumor cells of a tumor tissue sample previously taken from the same patient, comprising the following measures: - from the tumor tissue sample a tumor digest is prepared by carrying out an enzymatic digestion with collagenase at 30-37°C for 4-5 hours, centrifugation and resuspension, wherein said tumor digest contains cell clusters of malignant cells on the one hand and stroma cells, i.e. endothelial cells and fibroblasts on the other, - the cell clusters are incubated ex vivo with the active substance concerned by addition of aliquots of this tumor digests to previously prepared twice concentrated equal aliquots of active substance in culture medium, - the IC50 value of this active substance in the malignant cells is determined as the concentration of the active substance at which a half-maximal inhibition of colony formation is observably as compared to negative controls (0 μM active substance), - the ex vivo determined IC50-value is assigned to the documentation and/or classification of the therapy outcome which has been obtained with the same patient after treatment according to applicable evidence based therapy rules with the same active substance, and which has been documented and classified. - the applied concentrations of the active substance are verified by means of established in vitro cell strains of the same tumour entity which are examined in parallel. - from the tumor tissue sample a tumor digest is prepared by carrying out an enzymatic digestion with collagenase at 30-37°C for 4-5 hours, centrifugation and resuspension, wherein said tumor digest contains cell clusters of malignant cells on the one hand and stroma cells, i.e. endothelial cells and fibroblasts on the other, - the cell clusters are incubated ex vivo with the active substance concerned by addition of aliquots of this tumor digests to previously prepared twice concentrated equal aliquots of active substance in culture medium, - the IC50 value of this active substance in the malignant cells is determined as the concentration of the active substance at which a half-maximal inhibition of colony formation is observably as compared to negative controls (0 μM active substance), - the ex vivo determined IC50-value is assigned to the documentation and/or classification of the therapy outcome which has been obtained with the same patient after treatment according to applicable evidence based therapy rules with the same active substance, and which has been documented and classified. - the applied concentrations of the active substance are verified by means of established in vitro cell strains of the same tumour entity which are examined in parallel.
Closing device for closing a door leaf or a window sash, comprising a spring piston, which is acted upon by a spring, for applying a closing force to a closer shaft and a damping piston for damping the movement of the closer shaft, the damping piston and the spring piston each having a piston body (32, 62) which is molded and monolithically formed from the plastics or liquid state, characterized in that the piston body of the damping piston is formed from plastics material by injection molding and the piston body of the spring piston is formed from a zinc alloy by a zinc die casting method.
An autoinjector comprising a lower body (1010; 2010) receiving a tank, said tank containing fluid product and comprising a piston and a needle, such as a pre-filled syringe, said autoinjector comprising injection means (1005; 1008) to distribute said fluid product and an actuating sleeve (1011; 2011) comprising a contact end designed to make contact with the body of the user, said actuating sleeve (1011; 2011) being moveable relative to said lower body (1010; 2010) between projected positions, in which said actuating sleeve (1011; 2011) at least partially projects out of said lower body (1010; 2010), and an actuation position in which said actuating sleeve (1011; 2011) is axially moved towards the interior of said lower body (1010; 2010), said actuating sleeve (1011; 2011) being in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector, one from among said lower body (1010; 2010) and said actuating sleeve (1011; 2011) comprising a flexible foot (1110; 2110) adapted to deform laterally relative to the other from among said lower body (1010; 2010) and said actuating sleeve (1011; 2011) when said actuating sleeve is moved from its first projected position towards its actuation position and then back from its actuation position towards its second projected position, characterized in that the other from among said lower body (1010; 2010) and actuation sleeve (1011; 2011) comprises a final reception zone (105; 2105) offset axially and laterally relative to an opening (103; 2103), said opening (103; 2103) being connected to said final reception zone (105; 2105) by a laterally inclined groove (104;2104), an axial shoulder (106; 2106) being provided between said final reception zone (105; 2105) and said inclined groove (104; 2104), said flexible foot (1110; 2110) comprising a head adapted to slide in said laterally inclined groove (104; 2104) when said actuating sleeve (1011; 2011) returns from its actuation position towards its second projected position, laterally deforming said flexible foot (1110; 2110), said head shapping in under said axial shoulder (106; 2106) when said actuating sleeve reaches its second projected position, after use, thus locking said actuating sleeve (1011; 2011) relative to said lower body (1010; 2010), said flexible foot (1110; 2110) being deformed laterally when said actuating sleeve (1011; 2011) is moved from its first projected position, prior to actuation, towards its actuation position, and said flexible foot is deformed laterally when said actuating sleeve (1011; 2011) is moved from its actuation position towards its second projected position, at the end of use, said head of the flexible foot (1110; 2110) having to overcome a resistance to deform laterally at the beginning of the actuation.
A method for producing a second audio signal to be distributed on a second set of channels based on a first audio signal present on a first set of channels, comprising: - receiving the first audio signal; - decomposing the first audio signal into audio components according to a set of spectral bands; - receiving a set of mapping coefficients for mapping the audio components of the first audio signal in spectral bands of the first set of channels onto corresponding spectral bands of the second set of channels, wherein the set of mapping coefficients represent ratios of the band-based output-to-input signal level and the set of mapping coefficients are provided for each temporal period indicating a transform window and transform windows are overlapped at particular time (t), and the set of mapping coefficients are time varying coefficients that are defined in an encoding process; and - producing the second audio signal by mapping, by using the set of mapping coefficients, the audio components of the first audio signal in the spectral bands of the first set of channels onto the corresponding spectral bands of the second set of channels, wherein the second set of channels has a different number of channels from that of the first set of channels. - receiving the first audio signal; - decomposing the first audio signal into audio components according to a set of spectral bands; - receiving a set of mapping coefficients for mapping the audio components of the first audio signal in spectral bands of the first set of channels onto corresponding spectral bands of the second set of channels, wherein the set of mapping coefficients represent ratios of the band-based output-to-input signal level and the set of mapping coefficients are provided for each temporal period indicating a transform window and transform windows are overlapped at particular time (t), and the set of mapping coefficients are time varying coefficients that are defined in an encoding process; and - producing the second audio signal by mapping, by using the set of mapping coefficients, the audio components of the first audio signal in the spectral bands of the first set of channels onto the corresponding spectral bands of the second set of channels, wherein the second set of channels has a different number of channels from that of the first set of channels.
A tire comprising a tire frame member that has bead portions in which bead cores are embedded in a resin material and side portions that comprise the resin material and are continuous with tire radial direction outer sides of the bead portions, wherein: assuming that T1 is a thickness of thick-walled portions of the tire frame member, which are adjacent to tire radial direction outer sides of the bead cores, and that T2 is a thickness of the side portions, T1 > T2, a thickness of the tire frame member decreases from T1 to T2 between the thick-walled portions and the side portions, a position at which the thickness of the tire frame member starts to decrease from T1 to T2 is on a tire radial direction outer side of tire radial direction outer ends of rim flanges of a rim when the bead portions are mounted thereon, the thickness of the tire frame member gradually decreases from T1 to T2, characterized in that an aspect ratio of the thick-walled portions in a tire width direction cross section is 1.3 to 2.0. assuming that T1 is a thickness of thick-walled portions of the tire frame member, which are adjacent to tire radial direction outer sides of the bead cores, and that T2 is a thickness of the side portions, T1 > T2, a thickness of the tire frame member decreases from T1 to T2 between the thick-walled portions and the side portions, a position at which the thickness of the tire frame member starts to decrease from T1 to T2 is on a tire radial direction outer side of tire radial direction outer ends of rim flanges of a rim when the bead portions are mounted thereon, the thickness of the tire frame member gradually decreases from T1 to T2, characterized in that an aspect ratio of the thick-walled portions in a tire width direction cross section is 1.3 to 2.0.
Terrace roof with a front end supported by front supports (5, 6) and with a canopy (9, 10) projecting forwards over the plane spanned by the supports (5, 6), whereby the canopy (9, 10) is pivotable, characterised in that the terrace roof has a transverse beam which is supported by the front supports (5, 6) and to which the canopy (9, 10) is fastened so as to be pivotable.
A wireless device in a wireless communication network comprising multiple wireless devices capable of communicating with each other directly, comprising: a processing circuitry operative to multiplex data with a scheduling assignment message, into transmission information; and a transmitter operative to transmit the transmission information on one or more resource/s within subframes in a scheduling assignment period, to another wireless device in the wireless communication network, characterized in that the scheduling assignment message is used for indicating data transmission resource in the scheduling assignment period or in a previous scheduling assignment period, and the subframes are indicated by a bitmap signaling, and a same pattern based on the bitmap signaling is repeated for subframes over the length of the scheduling assignment period. a processing circuitry operative to multiplex data with a scheduling assignment message, into transmission information; and a transmitter operative to transmit the transmission information on one or more resource/s within subframes in a scheduling assignment period, to another wireless device in the wireless communication network, characterized in that the scheduling assignment message is used for indicating data transmission resource in the scheduling assignment period or in a previous scheduling assignment period, and the subframes are indicated by a bitmap signaling, and a same pattern based on the bitmap signaling is repeated for subframes over the length of the scheduling assignment period.
Device for producing an expanded granulate from mineral material in the form of grains of sand with an expanding agent, for example for producing an expanded granulate from perlite sand or obsidian sand with bonded water as expanding agent, the device comprising a furnace with a substantially vertical furnace shaft having an upper end and a lower end, wherein a conveying section extends between the two ends (5, 6) which passes through a plurality of heating zones arranged separately from one another in a conveying direction, wherein the heating zones each comprise at least one heating element which can be controlled independently of one another in order to heat the material at least to a critical temperature and to expand the sand grains, wherein furthermore at least one feeding means (10, 11) is provided, which is adapted to feed at least the unexpanded material at one of the two ends (5, 6) of the furnace shaft into the furnace shaft in the direction of the other of the two ends (6, 5) of the furnace shaft in order to expand the material, as viewed in conveying direction, in the last half, preferably in the last third, of the conveying section, wherein at least one directing element is provided, which is arranged at least in sections in the furnace shaft, wherein the directing element forms a gap with an inner wall of the furnace shaft at least in the region of the one of the two ends (5, 6) of the furnace shaft, wherein the at least one feeding means (10, 11) is adapted for feeding the unexpanded material into the gap, characterised in that releasable fastening means are provided for the at least one directing element in order to be able to remove the at least one directing element from the furnace shaft and reinsert it as required.
A method performed by a user equipment, the method comprising: receiving, from a base station (121, 122, 123, 124), IdleModeMobilityControlInfo for the user equipment to use for cell reselection; storing the IdleModeMobilityControlInfo; operating in an inactive state to suspend a radio resource control, RRC, connection to a first cell; processing a paging message, the paging message directing the user equipment to transition from the inactive state to an idle state; and responsive to processing the paging message, releasing the IdleModeMobilityControlInfo. receiving, from a base station (121, 122, 123, 124), IdleModeMobilityControlInfo for the user equipment to use for cell reselection; storing the IdleModeMobilityControlInfo; operating in an inactive state to suspend a radio resource control, RRC, connection to a first cell; processing a paging message, the paging message directing the user equipment to transition from the inactive state to an idle state; and responsive to processing the paging message, releasing the IdleModeMobilityControlInfo.
A detection unit comprising - detection means for detecting the occurrence of an event, said event being the detection of the passage of a ball through a detection gate that forms the detection unit, - processing means for controlling the operation of the detection unit, and - communication means for transmitting and receiving activation signals for interacting with further detection units, wherein - the processing means are designed for placing the detection unit into active mode upon receipt of an incoming activation signal, an active mode of said detection unit is indicated with any of: - sound and/or light signals, or - vibrations, or - heat, characterised in that the detection unit comprises a micro processing unit arranged for selecting a destination detection unit for passing said active mode thereto and in that the processing means are further designed for transmitting, in the active mode and upon detection of said event, an outgoing activation signal to said destination detection unit, and placing the detection unit into passive mode, wherein, in said passive mode, said detection unit only waits for the reception of an activation signal. - detection means for detecting the occurrence of an event, said event being the detection of the passage of a ball through a detection gate that forms the detection unit, - processing means for controlling the operation of the detection unit, and - communication means for transmitting and receiving activation signals for interacting with further detection units, wherein - the processing means are designed for placing the detection unit into active mode upon receipt of an incoming activation signal, an active mode of said detection unit is indicated with any of: - sound and/or light signals, or - vibrations, or - heat, characterised in that the detection unit comprises a micro processing unit arranged for selecting a destination detection unit for passing said active mode thereto and in that the processing means are further designed for transmitting, in the active mode and upon detection of said event, an outgoing activation signal to said destination detection unit, and placing the detection unit into passive mode, wherein, in said passive mode, said detection unit only waits for the reception of an activation signal. an active mode of said detection unit is indicated with any of: - sound and/or light signals, or - vibrations, or - heat, characterised in that the detection unit comprises a micro processing unit arranged for selecting a destination detection unit for passing said active mode thereto - sound and/or light signals, or - vibrations, or - heat, and in that the processing means are further designed for transmitting, in the active mode and upon detection of said event, an outgoing activation signal to said destination detection unit, and placing the detection unit into passive mode, wherein, in said passive mode, said detection unit only waits for the reception of an activation signal.
A method of determining the presence of high-risk prostate cancer in an individual, the method comprising a step of assaying a biological sample obtained from the individual for the presence of methylated regulatory DNA sequences as defined by SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9, SEQ ID NO 10, SEQ ID NO 11, SEQ ID NO 12, SEQ ID NO 13, SEQ ID NO 14, SEQ ID NO 15 and SEQ ID NO 16 and calculating a normalized index of methylation score, wherein the presence of the methylated regulatory DNA sequences as defined by SEQ ID NOs 7 to 16, and the calculated NIM score indicates a high-risk prostate cancer.
A method for protecting an electronic control unit, ECU, the ECU comprising a microprocessor, a microcontroller and a storage memory, the method comprising: - storing a first security artifact in the microprocessor, - storing a first program in the storage memory, the first program being based on the first security artifact, wherein in a normal mode which is used when no security breach is present, - the first program is transferred from the storage memory to the microprocessor, - the microprocessor authenticates (PK1_verify) the first program based on the first security artifact, and - in case the first program is successfully authenticated, the microprocessor executes the first program, wherein in a protected mode which is used in case it is detected that a security breach is present, - a second security artifact which is different from the first security artifact is stored in the microcontroller, - the second security artifact is transferred from the microcontroller to the microprocessor before a transfer of the first program from the storage memory to the microprocessor, - after having received the second security artifact, the microprocessor uses the second security artifact for authenticating (PK2_verify) a program, e.g. the first program, wherein the microprocessor requests the transfer of the first program, wherein in protected mode the request is redirected to the microcontroller. - storing a first security artifact in the microprocessor, - storing a first program in the storage memory, the first program being based on the first security artifact, - the first program is transferred from the storage memory to the microprocessor, - the microprocessor authenticates (PK1_verify) the first program based on the first security artifact, and - in case the first program is successfully authenticated, the microprocessor executes the first program, - a second security artifact which is different from the first security artifact is stored in the microcontroller, - the second security artifact is transferred from the microcontroller to the microprocessor before a transfer of the first program from the storage memory to the microprocessor, - after having received the second security artifact, the microprocessor uses the second security artifact for authenticating (PK2_verify) a program, e.g. the first program, wherein
A vibration absorber with a separable connection device in a piston rod, for producing an electrically conductive connection between at least a first electric line (11, 12), which can be introduced from outside into the piston rod, and at least a second electric line (6, 7), which is guided further in the piston rod, by means of plug connectors at the ends of the first (11, 12) and the second line (6, 7) that are to be connected to one another, which plug connectors can be rotated in relation to one another while maintaining the electrically conductive connection, wherein at least the plug connector of the first line (11, 12) is held by a first holding element in the piston rod, characterised in that the piston rod and the first holding element are connected to one another in such a way that the latter and the first electric line (11, 12), which is inserted from outside into the piston rod, with its associated plug connector do not rotate upon a rotation of the piston rod in the peripheral direction, while the plug connector corresponding to the plug connector of the first electric line (11, 12) participates in the rotation of the piston rod.