mhurhangee/ep-ind-claims huggingface dataset:
A glycosaminoglycan selected from chondroitin sulphates A to E, heparin, heparin sulphate, heparan, heparan sulphate and keratan sulphate or a physiologically acceptable salt of such a glycosaminoglycan for use in a method of treating a mammalian subject with a respiratory disorder or disease which comprises increased levels and/or viscosity of mucus or other pulmonary secretions, where the disease or disorder is selected from chronic airflow limitation, pneumonia, sinusitis, sinus congestion, cystic fibrosis, asthma, bronchitis, tracheobronchitis, bronchiectasis, tuberculosis, fungal infection, viral infection or a respiratory tract infection, wherein: - the subject is being treated with a therapeutic agent; - the glycosaminoglycan or salt and the therapeutic agent are administered via inhalation, intranasally and/or via instillation; - the agent is to be delivered to the respiratory tract; - the said glycosaminoglycan or salt thereof has an average molecular weight of from 12 to 18 kd; - the mucus or the other pulmonary secretions contains extracellular genomic DNA which is compromising lung function; and - the glycosaminoglycan increases delivery of the therapeutic agent. - the subject is being treated with a therapeutic agent; - the glycosaminoglycan or salt and the therapeutic agent are administered via inhalation, intranasally and/or via instillation; - the agent is to be delivered to the respiratory tract; - the said glycosaminoglycan or salt thereof has an average molecular weight of from 12 to 18 kd; - the mucus or the other pulmonary secretions contains extracellular genomic DNA which is compromising lung function; and - the glycosaminoglycan increases delivery of the therapeutic agent.
A closure, comprising an opening and a lid designed to close the opening, a sealing device with sealing elements being situated between the opening and the lid, one sealing element being designed to interact in a piston-like manner with a wall of the closure device when in the closed position, to allow a relative movement between the opening and the lid when the lid is placed under pressure, characterised in that the sealing device comprises a first and a second part-body (104.1, 104.2) and that a sealing element is situated between the part-bodies (104.1, 104.2) of the sealing device, and one of the part-bodies (104.1, 104.2) forms the wall for the sealing element.
A window module for a vehicle, in particular an automobile, comprising: - a fixed window comprising an internal face and an external face, - a movable window comprising an internal face and an external face, edges (14b, 22a) of the windows facing one another and defining a clearance between them, and the external faces (14d, 22d) of the windows being substantially aligned, - an elongated guide extending along said edges and attached to the internal face of the movable window, - an elongated upright extending along said edges and attached to the internal face of the fixed window, this upright having in cross-section a general U or L shape, one lateral branch of which extends along and facing said clearance, the upright comprising an internal face and an external face which at least partly defines a housing extending along said edges and intended to receive at least one part of the guide, a trim element being fitted and attached to said internal face of the upright, this trim element having an elongated shape and extending along the upright, this trim element comprising at least one retaining member, characterized in that this retaining member projects from said external face of the upright and comprises a face for retaining said part of the guide in said housing, in a direction substantially perpendicular to a plane which is perpendicular to the internal faces of the windows and which passes through said clearance. - a fixed window comprising an internal face and an external face, - a movable window comprising an internal face and an external face, edges (14b, 22a) of the windows facing one another and defining a clearance between them, and the external faces (14d, 22d) of the windows being substantially aligned, - an elongated guide extending along said edges and attached to the internal face of the movable window, - an elongated upright extending along said edges and attached to the internal face of the fixed window, this upright having in cross-section a general U or L shape, one lateral branch of which extends along and facing said clearance, the upright comprising an internal face and an external face which at least partly defines a housing extending along said edges and intended to receive at least one part of the guide,
An extruded polymer foam, the foam comprising a polymer matrix defining cells therein wherein the foam is characterized by: (a) the polymer matrix comprising styrene-acrylonitrile copolymer and 0.1 to 10 weight-percent infrared attenuator, based on foam weight, dispersed in the polymer matrix; (b) the cells having average sizes in the foam vertical, horizontal and extrusion directions, as determined by ASTM D-3576, such that i. the average size in the foam's vertical direction of 150 micrometers or less; ii. the ratio of average vertical direction cell size to average extrusion direction cell size that is greater than one; and iii. the cell anisotropic ratio that is greater than 1.1; (c) having a P-Ratio of 0.7 or less, determined according to the method in the description with compressive strength values determined according to ASTM D1621; (d) having less than 0.2 moles of hydrocarbon blowing agents in the cells per kilogram of foam as determined by gas chromatography; (e) having a density of 20 to 48 kilograms per cubic meter as determined by ASTM D1622; and (f) having an average 25-year thermal conductivity that is 0.030 Watts per meter-Kelvin or less when free of fluorinated blowing agents and less than 0.028 Watts per meter-Kelvin when containing fluorinated blowing agent, with 25-year thermal conductivity as determined by the slicing technique of EN13164. (a) the polymer matrix comprising styrene-acrylonitrile copolymer and 0.1 to 10 weight-percent infrared attenuator, based on foam weight, dispersed in the polymer matrix; (b) the cells having average sizes in the foam vertical, horizontal and extrusion directions, as determined by ASTM D-3576, such that i. the average size in the foam's vertical direction of 150 micrometers or less; ii. the ratio of average vertical direction cell size to average extrusion direction cell size that is greater than one; and iii. the cell anisotropic ratio that is greater than 1.1; i. the average size in the foam's vertical direction of 150 micrometers or less; ii. the ratio of average vertical direction cell size to average extrusion direction cell size that is greater than one; and iii. the cell anisotropic ratio that is greater than 1.1; (c) having a P-Ratio of 0.7 or less, determined according to the method in the description with compressive strength values determined according to ASTM D1621; (d) having less than 0.2 moles of hydrocarbon blowing agents in the cells per kilogram of foam as determined by gas chromatography; (e) having a density of 20 to 48 kilograms per cubic meter as determined by ASTM D1622; and (f) having an average 25-year thermal conductivity that is 0.030 Watts per meter-Kelvin or less when free of fluorinated blowing agents and less than 0.028 Watts per meter-Kelvin when containing fluorinated blowing agent, with 25-year thermal conductivity as determined by the slicing technique of EN13164.
An apparatus for handling a plurality of substrates, the apparatus comprising: a sorting unit; a rotatable support disposed within the sorting unit, the rotatable support rotatable about a rotation axis; a plurality of grippers coupled to a periphery of the rotatable support; and a plurality of bins positioned within the sorting unit below a path along which the plurality of grippers travels as the rotatable support rotates, wherein the bins are respectively associated with predefined substrate characteristics, wherein each bin of the plurality of bins is individually removable from the sorting unit, wherein the sorting unit is configured to sort the plurality of substrates into the plurality of bins according to substrate characteristics determined by testing the substrates, wherein the sorting unit is configured to release a first substrate of the plurality of substrates into a first bin of the plurality of bins associated with the substrate characteristics of the first substrate, and wherein the sorting unit is configured to continue to rotate the first substrate when no bins of the plurality of bins disposed below the path are available to receive the first substrate until a bin associated with the tested substrate characteristics of the first substrate becomes available below the path. a sorting unit; a rotatable support disposed within the sorting unit, the rotatable support rotatable about a rotation axis; a plurality of grippers coupled to a periphery of the rotatable support; and a plurality of bins positioned within the sorting unit below a path along which the plurality of grippers travels as the rotatable support rotates, wherein the bins are respectively associated with predefined substrate characteristics, wherein each bin of the plurality of bins is individually removable from the sorting unit, wherein the sorting unit is configured to sort the plurality of substrates into the plurality of bins according to substrate characteristics determined by testing the substrates, wherein the sorting unit is configured to release a first substrate of the plurality of substrates into a first bin of the plurality of bins associated with the substrate characteristics of the first substrate, and wherein the sorting unit is configured to continue to rotate the first substrate when no bins of the plurality of bins disposed below the path are available to receive the first substrate until a bin associated with the tested substrate characteristics of the first substrate becomes available below the path.
A hybrid side arm prosthesis for deployment in a branch vessel body lumen, the prosthesis comprising: a tubular stent body comprising a wire comprising a shape memory alloy, the tubular stent body having a self-expanding portion comprising the distal portion of the wire and a balloon-expandable portion comprising the proximal portion of the wire, wherein the shape memory alloy comprises an A f of less than 37°C in the self-expanding portion and an A s of greater than 37°C in the balloon-expandable portion, wherein the self-expanding distal portion of the wire has a helical configuration comprising bent wire portions alternating with straight wire portions in a helical zigzag pattern about a longitudinal axis of the stent body, the helical zig-zag pattern extending along the entire length of the distal portion, wherein the balloon-expandable proximal portion of the wire has a ring-like configuration including one or more rings centered about a longitudinal axis of the stent body, each of the one or more rings including bent wire portions alternating with straight wire portions in a circumferential zigzag pattern about the longitudinal axis. a tubular stent body comprising a wire comprising a shape memory alloy, the tubular stent body having a self-expanding portion comprising the distal portion of the wire and a balloon-expandable portion comprising the proximal portion of the wire, wherein the shape memory alloy comprises an A f of less than 37°C in the self-expanding portion and an A s of greater than 37°C in the balloon-expandable portion, wherein the self-expanding distal portion of the wire has a helical configuration comprising bent wire portions alternating with straight wire portions in a helical zigzag pattern about a longitudinal axis of the stent body, the helical zig-zag pattern extending along the entire length of the distal portion, wherein the balloon-expandable proximal portion of the wire has a ring-like configuration including one or more rings centered about a longitudinal axis of the stent body, each of the one or more rings including bent wire portions alternating with straight wire portions in a circumferential zigzag pattern about the longitudinal axis.
A process for producing methanol, which process comprises contacting H 2 and CO 2 with a solid catalyst, at a temperature of from 200 °C to 300 °C and at a reactant pressure of from 150 bar to 500 bar, which reactant pressure is the sum of the partial pressures of the H 2 and the CO 2, wherein: the molar ratio of the H 2 to the CO 2 is x:1.0, wherein x is from 2.5 to 3.5; and the catalyst comprises (i) a copper component which is Cu, CuO or Cu 2 O, or a mixture of two or three thereof, and (ii) ZnO, wherein the catalyst has a specific copper surface area (S Cu) of at least 10 m 2 /g-catalyst. the molar ratio of the H 2 to the CO 2 is x:1.0, wherein x is from 2.5 to 3.5; and the catalyst comprises (i) a copper component which is Cu, CuO or Cu 2 O, or a mixture of two or three thereof, and (ii) ZnO, wherein the catalyst has a specific copper surface area (S Cu) of at least 10 m 2 /g-catalyst.
A method comprising: using a z piezoelectric positioner fitted with a strain gauge sensor (z-SGS) to oscillate a scanning microscopy probe tip, in particular an ultramicroelectrode, in height relative to a surface of interest; detecting damping of an amplitude of the oscillation of the probe tip resulting from the probe tip coming into contact with the surface of interest by detecting a sustained decrease in the z piezoelectric strain gauge sensor (z-SGS) tip oscillation amplitude as compared to z piezoelectric strain gauge sensor (z-SGS) oscillation amplitude in bulk solution; using the detected damping to detect the surface of interest; and using the probe tip to measure or modify chemical activity of the surface of interest simultaneously with detecting damping. using a z piezoelectric positioner fitted with a strain gauge sensor (z-SGS) to oscillate a scanning microscopy probe tip, in particular an ultramicroelectrode, in height relative to a surface of interest; detecting damping of an amplitude of the oscillation of the probe tip resulting from the probe tip coming into contact with the surface of interest by detecting a sustained decrease in the z piezoelectric strain gauge sensor (z-SGS) tip oscillation amplitude as compared to z piezoelectric strain gauge sensor (z-SGS) oscillation amplitude in bulk solution; using the detected damping to detect the surface of interest; and using the probe tip to measure or modify chemical activity of the surface of interest simultaneously with detecting damping.
A tire reinforcement member comprising: at least one core material cord layer; and a spiral cord layer having reinforcing cords spirally wound on said core material cord layer, wherein reinforcing cords in said core material cord layer are metal cords having an inclination angle of 40° to 90° with respect to the longitudinal direction of said core material cord layer, and said reinforcing cords in said spiral cord layer are organic fiber cords having a modulus of not less than 19 GPa, wherein the distance between a metal cord at a width direction end of said core material cord layer and a reinforcing cord at a width direction end of said spiral cord layer is 0.2 to 20 times of the diameter of said metal cords of said core material cord layer, and wherein the modulus is a value of the initial tensile modulus measured in accordance with JIS L1013 at a test temperature of 25°C, a rate of 30 cm/min and a chuck distance of 250 mm. at least one core material cord layer; and a spiral cord layer having reinforcing cords spirally wound on said core material cord layer, wherein reinforcing cords in said core material cord layer are metal cords having an inclination angle of 40° to 90° with respect to the longitudinal direction of said core material cord layer, and said reinforcing cords in said spiral cord layer are organic fiber cords having a modulus of not less than 19 GPa, wherein the distance between a metal cord at a width direction end of said core material cord layer and a reinforcing cord at a width direction end of said spiral cord layer is 0.2 to 20 times of the diameter of said metal cords of said core material cord layer, and wherein the modulus is a value of the initial tensile modulus measured in accordance with JIS L1013 at a test temperature of 25°C, a rate of 30 cm/min and a chuck distance of 250 mm.
A dosage form comprising: a substrate that forms at least a first compartment and a second compartment, wherein the first compartment has a first aperture and the second compartment has a second aperture; a first drug contained in the first compartment; and a second drug contained in the second compartment; a first plug that seals the first aperture; and a second plug that seals the second aperture; wherein the first plug and the second plug are water soluble or erodible. a first drug contained in the first compartment; and a second drug contained in the second compartment; a first plug that seals the first aperture; and a second plug that seals the second aperture; wherein the first plug and the second plug are water soluble or erodible.
A device (232, 300) for forming a lumen in articular processes (20, 22) of a vertebral column, comprising: a shaft member comprising a proximal section and a distal section, a proximal handle, two movable lumen-forming members (206, 206) rotatably connected to the shaft member at about the distal section of the shaft member by a first pivot pin, wherein each movable lumen-forming member (206, 206) comprises a curved arm and a lumen-forming tip configured to pierce through a vertebral articular process (20, 22); and an actuator located at about the proximal section of the shaft member connected to a proximal end of a control rod within the shaft wherein the control rod is configured to move longitudinally upon manipulation of the actuator and wherein the control rod is connected at a distal end to a first end of two link members (226, 226) by a second pivot pin, wherein each link member (226, 226) is connected at a second end to one of the two movable lumen forming members by a third pivot pin; wherein the movable lumen-forming members (206, 206) have an open configuration wherein the lumen forming members (206, 206) are separated from each other and a closed configuration wherein the lumen forming members (206, 206) are in close proximity to each other. a shaft member comprising a proximal section and a distal section, a proximal handle, two movable lumen-forming members (206, 206) rotatably connected to the shaft member at about the distal section of the shaft member by a first pivot pin, wherein each movable lumen-forming member (206, 206) comprises a curved arm and a lumen-forming tip configured to pierce through a vertebral articular process (20, 22); and an actuator located at about the proximal section of the shaft member connected to a proximal end of a control rod within the shaft wherein the control rod is configured to move longitudinally upon manipulation of the actuator and wherein the control rod is connected at a distal end to a first end of two link members (226, 226) by a second pivot pin, wherein each link member (226, 226) is connected at a second end to one of the two movable lumen forming members by a third pivot pin; wherein the movable lumen-forming members (206, 206) have an open configuration wherein the lumen forming members (206, 206) are separated from each other and a closed configuration wherein the lumen forming members (206, 206) are in close proximity to each other.
A storage container for medical use to store liquids sucked from the thoracic cavity, the storage container comprising: a storing section including a storage space capable of storing liquid and including an inflow port for causing the liquid to flow into the storage space; and a water sealing section including a coupling space linked, to the storage space and a suction space linked to a suction source, the water sealing section being capable of sealing the coupling space and the suction space off from each other with water, wherein the storing section includes an inflow section connectable to a tube to allow the inflow port and an inner side of the tube to communicate and a volume changing section capable of changing volume of the storage space, and the volume changing section is deformed to increase the volume of the storage space when pressure in the storage space is about to rise to be equal to or higher than a reference pressure set in advance and is deformed to reduce the volume of the storage space when the pressure in the storage space is about to drop to be lower than the reference pressure. a storing section including a storage space capable of storing liquid and including an inflow port for causing the liquid to flow into the storage space; and a water sealing section including a coupling space linked, to the storage space and a suction space linked to a suction source, the water sealing section being capable of sealing the coupling space and the suction space off from each other with water, wherein the storing section includes an inflow section connectable to a tube to allow the inflow port and an inner side of the tube to communicate and a volume changing section capable of changing volume of the storage space, and the volume changing section is deformed to increase the volume of the storage space when pressure in the storage space is about to rise to be equal to or higher than a reference pressure set in advance and is deformed to reduce the volume of the storage space when the pressure in the storage space is about to drop to be lower than the reference pressure.