A compound of Formula I: or a salt thereof, wherein: Y is chosen from a bond, NR 4a, O, C NH, NHC, S, SO 2, and CH 2; Z is chosen from a bond, NR 4b, O, C NH, NHC, S, SO 2, and CH 2; m is an integer from 0 to 5; n is an integer from 0 to 3; R 1 and R 2 are each independently chosen from, alkyl, aminoalkyl, alkylsulfonylalkyl, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, phenyl, biphenyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl and R 1 and R 2, together with the nitrogen to which they attach, form a nitrogen-containing heterocycloalkyl ring which may be optionally substituted with between 0 and 3 R 6 groups; R 3 is chosen from alkylamino, cycloalkylamino, arylamino, heteroarylamino, heterocycloalkylamino, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl any of which may be optionally substituted with between 0 and 3 R 6 groups; R 4, R 4a, and R 4b are independently chosen from hydrogen, alkyl, alkenyl, alkynyl, and cycloalkyl; R 5 is chosen from aryl and heteroaryl, any of which may be optionally substituted with between 0 and 3 R 6 groups; each R 6 is independently chosen from hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkoxy, aryl, aralkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, cyano, alkoxy, amino, alkylamino, dialkylamino, COR 7, SO 2 R 7, NHSO 2 R 7, NHSO 2 NHR 7, NHCOR 7, NHCONHR 7, CONHR 7, and CONR 7 R 8; and R 7 and R 8 are independently chosen from hydrogen, and lower alkyl; or Rand 7 R 8 may be taken together to form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with C 1 -C 6 alkyl. Y is chosen from a bond, NR 4a, O, C NH, NHC, S, SO 2, and CH 2; Z is chosen from a bond, NR 4b, O, C NH, NHC, S, SO 2, and CH 2; m is an integer from 0 to 5; n is an integer from 0 to 3; R 1 and R 2 are each independently chosen from, alkyl, aminoalkyl, alkylsulfonylalkyl, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, phenyl, biphenyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl and R 1 and R 2, together with the nitrogen to which they attach, form a nitrogen-containing heterocycloalkyl ring which may be optionally substituted with between 0 and 3 R 6 groups; R 3 is chosen from alkylamino, cycloalkylamino, arylamino, heteroarylamino, heterocycloalkylamino, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl any of which may be optionally substituted with between 0 and 3 R 6 groups; R 4, R 4a, and R 4b are independently chosen from hydrogen, alkyl, alkenyl, alkynyl, and cycloalkyl; R 5 is chosen from aryl and heteroaryl, any of which may be optionally substituted with between 0 and 3 R 6 groups; each R 6 is independently chosen from hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkoxy, aryl, aralkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, cyano, alkoxy, amino, alkylamino, dialkylamino, COR 7, SO 2 R 7, NHSO 2 R 7, NHSO 2 NHR 7, NHCOR 7, NHCONHR 7, CONHR 7, and CONR 7 R 8; and R 7 and R 8 are independently chosen from hydrogen, and lower alkyl; or Rand 7 R 8 may be taken together to form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with C 1 -C 6 alkyl.