A brain navigation and stimulation system for delivery of a stimulatory electric field suitable for brain activity stimulation, comprising: a brain navigation lead (200, 512, 530, 700) comprising: an elongated body (204, 536) having a distal end and a proximal end, wherein said distal end is configured to penetrate through brain tissue: at least 3 micro-electrode contacts (706, 1030, 1034, 1038) distributed along an outer surface of said elongated lead body close to said distal end, wherein said at least 3 micro-electrode contacts are positioned along said outer surface of the lead body at angular positions facing different brain regions around the brain navigation lead; at least one macro-electrode contact (202, 716, 1028, 1036) located proximal to said at least 3 micro-electrode contacts; a pulse generator (208, 524) electrically connected to the brain navigation lead; characterized in that said at least one macro-electrode contact is located at an angular position along said outer surface of the lead body, and that said at least 3 micro-electrode contacts are positioned at said angular positions facing said different brain regions around the brain navigation lead to allow directional recording of electric activity by at least one micro-electrode contact of said at least 3 micro-electrode contacts and said at least one macro-electrode contact, from the different brain regions as the brain navigation lead is inserted along an inserting trajectory into the brain; and wherein said pulse generator is configured to generate and deliver a directional stimulatory electric field suitable for brain activity stimulation, to brain tissue around the lead through said at least one macro-electrode contact and at least one micro-electrode contact of said at least 3 micro-electrode contacts. a brain navigation lead (200, 512, 530, 700) comprising: an elongated body (204, 536) having a distal end and a proximal end, wherein said distal end is configured to penetrate through brain tissue: at least 3 micro-electrode contacts (706, 1030, 1034, 1038) distributed along an outer surface of said elongated lead body close to said distal end, wherein said at least 3 micro-electrode contacts are positioned along said outer surface of the lead body at angular positions facing different brain regions around the brain navigation lead; at least one macro-electrode contact (202, 716, 1028, 1036) located proximal to said at least 3 micro-electrode contacts; an elongated body (204, 536) having a distal end and a proximal end, wherein said distal end is configured to penetrate through brain tissue: at least 3 micro-electrode contacts (706, 1030, 1034, 1038) distributed along an outer surface of said elongated lead body close to said distal end, wherein said at least 3 micro-electrode contacts are positioned along said outer surface of the lead body at angular positions facing different brain regions around the brain navigation lead; at least one macro-electrode contact (202, 716, 1028, 1036) located proximal to said at least 3 micro-electrode contacts; at least 3 micro-electrode contacts (706, 1030, 1034, 1038) distributed along an outer surface of said elongated lead body close to said distal end, wherein said at least 3 micro-electrode contacts are positioned along said outer surface of the lead body at angular positions facing different brain regions around the brain navigation lead; at least one macro-electrode contact (202, 716, 1028, 1036) located proximal to said at least 3 micro-electrode contacts; a pulse generator (208, 524) electrically connected to the brain navigation lead; characterized in that said at least one macro-electrode contact is located at an angular position along said outer surface of the lead body, and that said at least 3 micro-electrode contacts are positioned at said angular positions facing said different brain regions around the brain navigation lead to allow directional recording of electric activity by at least one micro-electrode contact of said at least 3 micro-electrode contacts and said at least one macro-electrode contact, from the different brain regions as the brain navigation lead is inserted along an inserting trajectory into the brain; and wherein said pulse generator is configured to generate and deliver a directional stimulatory electric field suitable for brain activity stimulation, to brain tissue around the lead through said at least one macro-electrode contact and at least one micro-electrode contact of said at least 3 micro-electrode contacts. characterized in that said at least one macro-electrode contact is located at an angular position along said outer surface of the lead body, and that said at least 3 micro-electrode contacts are positioned at said angular positions facing said different brain regions around the brain navigation lead to allow directional recording of electric activity by at least one micro-electrode contact of said at least 3 micro-electrode contacts and said at least one macro-electrode contact, from the different brain regions as the brain navigation lead is inserted along an inserting trajectory into the brain; and wherein said pulse generator is configured to generate and deliver a directional stimulatory electric field suitable for brain activity stimulation, to brain tissue around the lead through said at least one macro-electrode contact and at least one micro-electrode contact of said at least 3 micro-electrode contacts.