mhurhangee/ep-ind-claims huggingface dataset:
A method of synthesizing an insulin polypeptide-oligomer conjugate comprising: (a) contacting a proinsulin polypeptide with an oligomer comprising a hydrophilic moiety and a lipophilic moiety under conditions sufficient to couple the oligomer to the proinsulin polypeptide at Lys29 of chain B of the proinsulin, and provide a proinsulin polypeptide-oligomer conjugate, wherein the conditions sufficient to couple the oligomer to the proinsulin polypeptide comprise acylation with a hydroxysuccinimide ester to the Lys29 of chain B of insulin, and wherein the hydrophilic moiety comprises a polyalkylene glycol moiety, wherein the proinsulin polypeptide comprises: an A and B chain of insulin and non-insulin connecting polypeptides or amino acid residues that connect the A and B chain to each other, wherein the proinsulin polypeptide with connecting polypeptides or amino acid residues is selected from: His-Gly-Arg-B-chain-Arg-A-chain; His-Gly-Arg-B-chain-Arg-Arg-A-chain; Leader peptide-Arg-B-chain-Arg-Ala-Lys-Arg-A-chain; or Leader peptide-Arg-B-chain-Arg-Pro-Arg-A-chain; and (b) cleaving the leader peptide and the non-insulin polypeptides from the proinsulin polypeptide-oligomer conjugate with a cleavage enzyme to provide the insulin polypeptide-oligomer conjugate. (a) contacting a proinsulin polypeptide with an oligomer comprising a hydrophilic moiety and a lipophilic moiety under conditions sufficient to couple the oligomer to the proinsulin polypeptide at Lys29 of chain B of the proinsulin, and provide a proinsulin polypeptide-oligomer conjugate, wherein the conditions sufficient to couple the oligomer to the proinsulin polypeptide comprise acylation with a hydroxysuccinimide ester to the Lys29 of chain B of insulin, and wherein the hydrophilic moiety comprises a polyalkylene glycol moiety, wherein the proinsulin polypeptide comprises: an A and B chain of insulin and non-insulin connecting polypeptides or amino acid residues that connect the A and B chain to each other, wherein the proinsulin polypeptide with connecting polypeptides or amino acid residues is selected from: His-Gly-Arg-B-chain-Arg-A-chain; His-Gly-Arg-B-chain-Arg-Arg-A-chain; Leader peptide-Arg-B-chain-Arg-Ala-Lys-Arg-A-chain; or Leader peptide-Arg-B-chain-Arg-Pro-Arg-A-chain; and an A and B chain of insulin and non-insulin connecting polypeptides or amino acid residues that connect the A and B chain to each other, wherein the proinsulin polypeptide with connecting polypeptides or amino acid residues is selected from: His-Gly-Arg-B-chain-Arg-A-chain; His-Gly-Arg-B-chain-Arg-Arg-A-chain; Leader peptide-Arg-B-chain-Arg-Ala-Lys-Arg-A-chain; or Leader peptide-Arg-B-chain-Arg-Pro-Arg-A-chain; and His-Gly-Arg-B-chain-Arg-A-chain; His-Gly-Arg-B-chain-Arg-Arg-A-chain; Leader peptide-Arg-B-chain-Arg-Ala-Lys-Arg-A-chain; or Leader peptide-Arg-B-chain-Arg-Pro-Arg-A-chain; and (b) cleaving the leader peptide and the non-insulin polypeptides from the proinsulin polypeptide-oligomer conjugate with a cleavage enzyme to provide the insulin polypeptide-oligomer conjugate.
Wind generation means comprising at least one wind generation wall comprising a plurality of wind generation units provided next to each other along at least a first and a second directions so as to form the at least one wind generation wall, wherein each wind generation unit of said plurality of wind generation units comprises at least two ventilation units, each ventilation unit within the wind generation unit being individually controlled characterized in that each ventilation unit is composed of two contra-rotative ventilation fans (1111, 1112) mounted in series, and in that each wind generation unit of said plurality of wind generation units comprises at least one control unit adapted to control said ventilation units individually, so as to generate an specific wind profile both in space and in time in an air flow path and so as to vary a generated wind physical property of said each wind generation unit along said at least first and second directions, and in that said plurality of wind generation units are detachably attached to each other so that the size and shape of the said wind generation wall can be varied, and further comprising, in the air flow path, a first frame having a honeycomb structure and a second frame providing a plurality of homogenization chambers mounted to the wind generation units, wherein each ventilation unit is provided with its specific homogenization chamber. at least one wind generation wall comprising a plurality of wind generation units provided next to each other along at least a first and a second directions so as to form the at least one wind generation wall, wherein each wind generation unit of said plurality of wind generation units comprises at least two ventilation units, each ventilation unit within the wind generation unit being individually controlled characterized in that each ventilation unit is composed of two contra-rotative ventilation fans (1111, 1112) mounted in series, and in that each wind generation unit of said plurality of wind generation units comprises at least one control unit adapted to control said ventilation units individually, so as to generate an specific wind profile both in space and in time in an air flow path and so as to vary a generated wind physical property of said each wind generation unit along said at least first and second directions, and in that said plurality of wind generation units are detachably attached to each other so that the size and shape of the said wind generation wall can be varied, and further comprising, in the air flow path, a first frame having a honeycomb structure and a second frame providing a plurality of homogenization chambers mounted to the wind generation units, wherein each ventilation unit is provided with its specific homogenization chamber.
Composite film, preferably intended for use in the construction industry and/or preferably for use as a construction film, having at least one functional layer, at least one outer protective layer and at least one inner protective layer, wherein the functional layer is arranged between the outer protective layer and the inner protective layer, wherein the functional layer is formed as at least a single-layer membrane layer, wherein the outer protective layer and the inner protective layer are formed as a nonwoven layer comprising polyethylene terephthalate, wherein the outer protective layer and/or the inner protective layer comprises at least one bicomponent fiber having a first component and a second component, wherein the first component comprises a first polymer and the second component comprises a second polymer as a constituent, wherein the functional layer comprises and/or consists of plastic and/or synthetic resin, namely an elastomeric material and thermoplastic material, as the material, and wherein the composite film is permeable to water vapor and open to diffusion, wherein the composite film has a S d value of less than or equal to 0.5 m. wherein the functional layer is formed as at least a single-layer membrane layer, wherein the outer protective layer and the inner protective layer are formed as a nonwoven layer comprising polyethylene terephthalate, wherein the outer protective layer and/or the inner protective layer comprises at least one bicomponent fiber having a first component and a second component, wherein the first component comprises a first polymer and the second component comprises a second polymer as a constituent, wherein the functional layer comprises and/or consists of plastic and/or synthetic resin, namely an elastomeric material and thermoplastic material, as the material, and wherein the composite film is permeable to water vapor and open to diffusion, wherein the composite film has a S d value of less than or equal to 0.5 m.
A ring for sensing one or more physiological and/or behavioural parameters of a user, the ring comprising: an aperture for receiving a finger of the user therethrough, the aperture comprising: a sensing portion comprising a substantially V-shaped portion, the substantially V-shaped portion having an apex that extends along the entire ring width, the apex comprising an angle of between 85° and 120°; one or more sensing means disposed in the V-shaped portion; and a pad disposed in the aperture and opposing the sensing portion, wherein the pad is configured to urge the finger against the one or more sensing means in the V-shaped portion when the finger is received in the aperture, such that a central position on an underside of the finger may be substantially aligned with the apex of the substantially V-shaped portion. a sensing portion comprising a substantially V-shaped portion, the substantially V-shaped portion having an apex that extends along the entire ring width, the apex comprising an angle of between 85° and 120°; one or more sensing means disposed in the V-shaped portion; and a pad disposed in the aperture and opposing the sensing portion,
A computer-implemented method for obtaining a physical model having physical model parameters wherein solutions (field) to one or more partial-differential-equations (PDE's) are calculated, wherein the PDE's are constrained by observed data from a system whose response to a known source function and known sampling operator is modeled by solutions of those PDEs for a given physical model using physical model parameters, wherein (i) an appropriate initial model is selected, (ii) a system of equations for the field is set up, referred to as the data-augmented PDE for the field, comprising of the discretized PDE, the sampling operator, the source function and the observed data, and solve the data-augmented PDE in a suitable manner to obtain a field that both satisfies the PDE and fits the observed data to some degree, (iii) a system of equations is set up by using the PDE, the source function and the field obtained in step (ii) and solve this system of equations in a suitable manner to obtain an update of the physical model parameters and repeat steps (ii)-(iii) until a predetermined stopping criterion is met.
A variant of a parent alpha-amylase, wherein said variant has a sequence identical to the sequence according to SEQ ID NO: 1 except for the amino acid motif selected from the group of FSSK, FSLK, and FRLK at positions 179 to 182 of SEQ ID NO: 1; and wherein said variant has an improved Residual Activity compared to an alpha-amylase comprising the motif FRSK.
A cosmetic method of controlling a skin cooling treatment system comprising a mechanical arm having a cryospray applicator coupled to a distal end of the mechanical arm, the method comprising: receiving imagery of a portion of skin of a patient for receiving a skin cooling treatment; automatically identifying boundaries from the received imagery to designate portions of the skin of the patient for receiving the skin cooling treatment; determining an instantaneous treatment footprint; generating a treatment path for the portion of skin of the patient designated for receiving the skin cooling treatment based on the treatment footprint; delivering the skin cooling treatment to the skin according to the treatment path; determine dosage modification based on retrieved image and/or sensor data; changing the dosage by changing the size of the instantaneous treatment footprint while delivering the skin cooling treatment to the skin region and generating a modified treatment path depending on the changed size of the instantaneous treatment footprint receiving imagery of a portion of skin of a patient for receiving a skin cooling treatment; automatically identifying boundaries from the received imagery to designate portions of the skin of the patient for receiving the skin cooling treatment; determining an instantaneous treatment footprint; generating a treatment path for the portion of skin of the patient designated for receiving the skin cooling treatment based on the treatment footprint; delivering the skin cooling treatment to the skin according to the treatment path; determine dosage modification based on retrieved image and/or sensor data; changing the dosage by changing the size of the instantaneous treatment footprint while delivering the skin cooling treatment to the skin region and generating a modified treatment path depending on the changed size of the instantaneous treatment footprint
A lifter for handling a rotor blade of a wind turbine, the lifter comprising at least one device for contacting an outer surface of the rotor blade in a predetermined grabbing area, characterized in that the outer surface of the rotor blade comprises at least one invisible mark which indicates a position and a contour of the at least one grabbing area, and wherein the invisible mark comprises a long term invisible paint or label that is invisible to the naked human eye in daylight and the lifter further comprises a detector for detecting the invisible mark.
An apparatus comprising: a transconductance amplifier comprising split cascode current paths, the split cascode current paths comprising a first current path from a cascode node to a first output and a second current path from the cascode node to a second output, and the transconductance amplifier is configured to receive a radio frequency input voltage, provide a RF output current to the first output, and provide the RF output current to the second output; mixers comprising a first mixer and a second mixer; and a capacitance circuit comprising a first capacitor and a second capacitor, the first capacitor electrically coupled between the first output of the transconductance amplifier and an input of the first mixer, and the second capacitor electrically coupled between the second output of the transconductance amplifier and an input of the second mixer; the apparatus characterized in that: the RF output current is provided to the first output when the RF input voltage is in a first frequency band, and the RF output current is provided to the second output when the RF input voltage is in a second frequency band, wherein the first frequency band is associated with lower frequencies of the RF input voltage than the second frequency band; and the capacitance of the first capacitor is greater than the capacitance of the second capacitor. a transconductance amplifier comprising split cascode current paths, the split cascode current paths comprising a first current path from a cascode node to a first output and a second current path from the cascode node to a second output, and the transconductance amplifier is configured to receive a radio frequency input voltage, provide a RF output current to the first output, and provide the RF output current to the second output; mixers comprising a first mixer and a second mixer; and a capacitance circuit comprising a first capacitor and a second capacitor, the first capacitor electrically coupled between the first output of the transconductance amplifier and an input of the first mixer, and the second capacitor electrically coupled between the second output of the transconductance amplifier and an input of the second mixer; the apparatus characterized in that: the RF output current is provided to the first output when the RF input voltage is in a first frequency band, and the RF output current is provided to the second output when the RF input voltage is in a second frequency band, wherein the first frequency band is associated with lower frequencies of the RF input voltage than the second frequency band; and the capacitance of the first capacitor is greater than the capacitance of the second capacitor. the RF output current is provided to the first output when the RF input voltage is in a first frequency band, and the RF output current is provided to the second output when the RF input voltage is in a second frequency band, wherein the first frequency band is associated with lower frequencies of the RF input voltage than the second frequency band; and the capacitance of the first capacitor is greater than the capacitance of the second capacitor.
Rotary electrical machine, comprising: - a stator, comprising teeth, and - a rotor, comprising a shaft and permanent magnets arranged on the surface of the shaft, the permanent magnets comprising a face of concave overall shape directed towards the stator, a concave face of a permanent magnet of the rotor comprises a concave portion, the concave portion of a concave face being arranged between two planar lateral portions, the magnets having, when the machine is viewed along the axis of rotation, a cross section of elongate shape, the rotor being internal, the machine being characterized in that the width of the concave portion, measured perpendicular to a radius of the rotor, is between 0.1π(D S -2 d)/P and 2π(D S -2 d)/P mm (millimetres), where D S is the bore diameter of the stator, P is the number of poles of the rotor, and d is the simple air gap, i.e. the smallest width of the air gap, the teeth of the stator having end faces of concave shape directed towards the rotor. - a stator, comprising teeth, and - a rotor, comprising a shaft and permanent magnets arranged on the surface of the shaft, the permanent magnets comprising a face of concave overall shape directed towards the stator, a concave face of a permanent magnet of the rotor comprises a concave portion, the concave portion of a concave face being arranged between two planar lateral portions, the magnets having, when the machine is viewed along the axis of rotation, a cross section of elongate shape, the rotor being internal, the machine being characterized in that the width of the concave portion, measured perpendicular to a radius of the rotor, is between 0.1π(D S -2 d)/P and 2π(D S -2 d)/P mm (millimetres), where D S is the bore diameter of the stator, P is the number of poles of the rotor, and d is the simple air gap, i.e. the smallest width of the air gap, the teeth of the stator having end faces of concave shape directed towards the rotor.
A multiplexing method for generating bitstreams by coding a moving picture on a basis of a clip of the moving picture, and packet-multiplexing the bitstreams, said multiplexing method comprising: judging whether or not the clip to be coded should be coded as part of a continuous reproduction unit in which bitstreams are structured so as to allow continuous reproduction; determining, for the clip to be coded, a color space that is common within the continuous reproduction unit, when it is judged that the clip to be coded should be coded as part of the continuous reproduction unit; generating bitstreams by coding the clip to be coded according to the determined color space; and packet-multiplexing the bitstreams, wherein, in said judging whether or not the clip to be coded should be coded as part of the continuous reproduction unit, the bitstreams that are structured so as to allow multi-angle reproduction are treated as the continuous reproduction unit. judging whether or not the clip to be coded should be coded as part of a continuous reproduction unit in which bitstreams are structured so as to allow continuous reproduction; determining, for the clip to be coded, a color space that is common within the continuous reproduction unit, when it is judged that the clip to be coded should be coded as part of the continuous reproduction unit; generating bitstreams by coding the clip to be coded according to the determined color space; and packet-multiplexing the bitstreams, wherein, in said judging whether or not the clip to be coded should be coded as part of the continuous reproduction unit, the bitstreams that are structured so as to allow multi-angle reproduction are treated as the continuous reproduction unit.
Cannula (1; 11) designed to be inserted into tear ducts for receiving a wire connected to a probe that is to be inserted into the tear duct, the wire being guided into the cannula so as to traverse the tear duct in this way up to the exit of the latter on the side of the nasal cavity, the surgeon then removing the cannula through the other exit of the duct (on the side of the eyes) then pulling the wire to bring the probe into position in the tear duct, the cannula comprising an oblong, hollow cylindrical body open at one end and closed at its other outer end, a lateral slot extending from the open end towards the closed outer end ending with a lateral opening with a larger width dimension than the slot, the width being measured in a direction perpendicular to the longitudinal direction along which the slot extends, the opening allowing the passage within it of a guide wire introduced through the opening of the open end into the cylindrical hollow body for a relative sliding by pulling of the cannula and the guide wire, characterised in that - the form and the dimension of the cannula are such that the guide wire, in particular its free end designed to come out of the cannula through the opening, cannot, once inserted into the cannula through the opening of the open end, penetrate into the part of the cannula beyond the opening between the latter and the closed outer end of the cannula; - the cannula comprises an internal wall forming the base of the cannula which closes the spacing between the end of the opening in the direction of the closed outer end and said closed outer end; and - the internal wall of the base of the cannula which is located substantially at the level of the end of the opening in the longitudinal direction towards the outer closed end makes an angle lower than 90°, in particular comprised between 15 and 30°, with the longitudinal axis, so as to form a guiding ramp toward the top, namely towards the opening, for the wire end which is made to slide in the cannula by pushing it through the opening of the cannula. - the form and the dimension of the cannula are such that the guide wire, in particular its free end designed to come out of the cannula through the opening, cannot, once inserted into the cannula through the opening of the open end, penetrate into the part of the cannula beyond the opening between the latter and the closed outer end of the cannula; - the cannula comprises an internal wall forming the base of the cannula which closes the spacing between the end of the opening in the direction of the closed outer end and said closed outer end; and - the internal wall of the base of the cannula which is located substantially at the level of the end of the opening in the longitudinal direction towards the outer closed end makes an angle lower than 90°, in particular comprised between 15 and 30°, with the longitudinal axis, so as to form a guiding ramp toward the top, namely towards the opening, for the wire end which is made to slide in the cannula by pushing it through the opening of the cannula.
A rack steering system for a motor vehicle, with a rack slidably mounted along its longitudinal direction, a steering pinion in engagement with the rack, a pusher device elastically applying the rack against the steering pinion, said steering system including at least one stationary ring crossed by the rack, and with damping means composed of an annular-shaped damping element, placed at the periphery of the ring, said ring being mounted around the rack and having internally eccentric bearings in frictional contact with the rack, said steering system being characterized in that the ring includes two eccentric inner bearings relative to the periphery of said ring, symmetrical to one another, which are in frictional contact with the rack in opposite areas located, in sectional view, between the foot of the teeth of the rack, and the longitudinal axis of this rack.