A system for navigating to and interacting with a region of interest during a respiratory cycle, the system comprising: an extended working channel defining a lumen extending therethrough for receiving a tool to be navigated to a region of interest; a computing device including a memory and at least one processor; a plurality of images stored in the memory; a display device that is adapted to display a user interface; the at least one processor configured to: determine movement of the tool during the respiratory cycle of a patient using a tracking system and an electromagnetic sensor; obtain one or more patient health metrics from a database, wherein said patient health metrics are based on sensor locations obtained during an initial CT scan; and determine likely movement of airways and the region of interest during the respiratory cycle of the patient based on a comparison of determined movement of the tool and the obtained one or more patient health metrics; and a program stored in the memory that, when executed by the at least one processor, presents the user interface, the user interface including: at least one image of the plurality of images depicting the region of interest and a progression of the extended working channel through the airways; and a probability diagnostic and/or treatment zone defining a volume representing a probable distribution of a trajectory of the tool once deployed beyond an opening of the extended working channel displayed in the at least one image based on the likely movement of airways and region of interest during respiratory cycle. an extended working channel defining a lumen extending therethrough for receiving a tool to be navigated to a region of interest; a computing device including a memory and at least one processor; a plurality of images stored in the memory; a display device that is adapted to display a user interface; the at least one processor configured to: determine movement of the tool during the respiratory cycle of a patient using a tracking system and an electromagnetic sensor; obtain one or more patient health metrics from a database, wherein said patient determine movement of the tool during the respiratory cycle of a patient using a tracking system and an electromagnetic sensor; obtain one or more patient health metrics from a database, wherein said patient health metrics are based on sensor locations obtained during an initial CT scan; and determine likely movement of airways and the region of interest during the respiratory cycle of the patient based on a comparison of determined movement of the tool and the obtained one or more patient health metrics; and a program stored in the memory that, when executed by the at least one processor, presents the user interface, the user interface including: at least one image of the plurality of images depicting the region of interest and a progression of the extended working channel through the airways; and a probability diagnostic and/or treatment zone defining a volume representing a probable distribution of a trajectory of the tool once deployed beyond an opening of the extended working channel displayed in the at least one image based on the likely movement of airways and region of interest during respiratory cycle. at least one image of the plurality of images depicting the region of interest and a progression of the extended working channel through the airways; and a probability diagnostic and/or treatment zone defining a volume representing a probable distribution of a trajectory of the tool once deployed beyond an opening of the extended working channel displayed in the at least one image based on the likely movement of airways and region of interest during respiratory cycle.