A compound of Formula II: or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof, wherein, Y is hydrogen, halo, cyano, (C 1 -C 3)alkyl, (C 1 -C 3)hydroxyalkyl, (C 1 -C 5)alkenyl, (C 1 -C 3)haloalkyl, (C 1 -C 3)hydroxyhaloalkyl, (C 3 -C 6)cycloalkyl, (C 1 -C 3)alkoxy or (C 1 -C 3)haloalkoxy; R 1 is hydrogen, (C 1 -C 6)alkyl, (C 1 -C 6)hydroxyalkyl or (C 1 -C 6)haloalkyl; X is W is optionally substituted with one, two, three, four or five substitutents independently selected for each occurrence from the group consisting of halo, (C 1 -C 6)alkyl, (C 1 -C 6)hydroxyalkyl and (C 1 -C 6)haloalkyl; R 3 is (C 1 -C 6)alkyl, (C 3 -C 8)cycloalkyl, (C 3 -C 8)heterocycloalkyl, aryl, heteroaryl, -C(=O)R 4, -C(=O)OR 4, -C(=O)N(R 5) 2 or -S(=O) 2 R 4, optionally substituted with one, two, three, four or five substitutents independently selected for each occurrence from the group consisting of halo, cyano, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)cyanoalkyl, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)alkoxy, (C 1 -C 4)alkoxy(C 1 -C 4)alkyl, (C 1 -C 4)haloalkoxy, -NR 2, (R 2 N)(C 1 -C 4)alkyl-, (C 1 -C 4)alkylthio, (C 1 -C 4)haloalkylthio, -C(=O)R, -C(=O)OR, -OC(=O)R, -C(=O)NR 2, -N C(=O)R, -CH 2 C (=O)R, -CH 2 C(=O)OR, -CH 2 OC(=O)R, -CH 2 C(=O)NR 2, -CH 2 N C(=O)R, -S(=O) 2 R, -S( =O) 2 NR 2, -N S(=O) 2 R, -A and -CH 2 A; R 4 is hydrogen, (C 1 -C 6)alkyl, (C 3 -C 8)cycloalkyl, (C 3 -C 8)heterocycloalkyl, (C 3 -C 8)cycloalkyl(C 1 -C 6)alkyl, (C 3 -C 8)heterocycloalkyl(C 1 -C 6)alkyl, aryl or heteroaryl, optionally substituted with one, two, three, four or five substitutents independently selected for each occurrence from the group consisting of halo, cyano, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)cyanoalkyl, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)alkoxy, (C 1 -C 6)alkoxy(C 1 -C 6)alkyl, (C 1 -C 6)haloalkoxy, -NR 2, (R 2 N)(C 1 -C 6)alkyl, (C 1 -C 6)alkylthio, (C 1 -C 6)haloalkylthio, -C(=O)R, -C(=O)OR, -OC(=O)R, -C(=O)NR 2, -N C(=O)R, -CH 2 C(=O) R, -CH 2 C(=O)OR, -CH 2 OC(=O)R, -CH 2 C(=O)NR 2, -CH 2 N C(=O)R, -S(=O) 2 R, -S(=O) 2 NR 2, -N S(=O) 2 R, -A and -CH 2 A; and R 5 is independently selected for each occurrence from the group consisting of hydrogen, (C 1 -C 6)alkyl, (C 3 -C 8)cycloalkyl, (C 3 -C 8)heterocycloalkyl, (C 3 -C 8)cycloalkyl(C 1 -C 6)alkyl, (C 3 -C 8)heterocycloalkyl(C 1 -C 6)alkyl, aryl and heteroaryl, optionally substituted with one, two, three, four or five substitutents independently selected for each occurrence from the group consisting of halo, cyano, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)cyanoalkyl, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)alkoxy, (C 1 -C 4)alkoxy(C 1 -C 4)alkyl, (C 1 -C 4)haloalkoxy, -NR 2, (R 2 N)(C 1 -C 4)alkyl-, (C 1 -C 4)alkylthio, (C 1 -C 4)haloalkylthio, -C(=O)R, -C(=O)OR, -OC(=O)R, -C(=O)NR 2, -N C(=O)R, -CH 2 C(=O) R, -CH 2 C(=O)OR, -CH 2 OC(=O)R, -CH 2 C(=O)NR 2, -CH 2 N C(=O)R, -S(=O) 2 R, -S(=O) 2 NR 2, -N S(=O) 2 R, -A and -CH 2 A; or where a nitrogen is substituted with two R 5 groups may be taken together with the nitrogen atom to which they are attached to form a 4-, 5-, 6- or 7-membered saturated C 3-8 heterocycloalkyl which, when so formed, may be optionally substituted with one, two or three substituents independently selected from the group consisting of (C 1 -C 4)alkyl, halo, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)haloalkyl and =O; R is independently selected for each occurrence from the group consisting of hydrogen, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)cyanoalkyl, (C 1 -C 4)hydroxyalkyl, (C 3 -C 8)cycloalkyl or (C 3 -C 8)heterocycloalkyl; or where a nitrogen is substituted with two R groups they may be taken together with the nitrogen atom to which they are attached to form a 4-, 5-, 6- or 7-membered saturated (C 3 -C 8)heterocycloalkyl which, when so formed, may be optionally substituted with one, two or three substituents independently selected from the group consisting of (C 1 -C 4)alkyl, halo, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)cyanoalkyl, (C 1 -C 4)haloalkyl and =O; and A is independently selected for each occurrence from the group consisting of (C 3 -C 8)cycloalkyl, (C 3 -C 8)heterocycloalkyl, aryl and heteroaryl, optionally substituted with one, two, three, four or five substitutents independently selected for each occurrence from the group consisting of halo, cyano, (C 1 -C 4)alkyl, (C 1 -C 4)haloalkyl, (C 1 -C 4)cyanoalkyl, hydroxyl, (C 1 -C 4)hydroxyalkyl, (C 1 -C 4)alkoxy, (C 1 -C 4)alkoxy(C 1 -C 4)alkyl, (C 1 -C 4)haloalkoxy, -NR 2, (R 2 N)(C 1 -C 4)alkyl-, (C 1 -C 4)alkylthio, (C 1 -C 4)haloalkylthio, -C(=O)R, -C(=O)OR, -OC(=O)R, -C(=O)NR 2, -N C(=O)R, -CH 2 C(=O) R, -CH 2 C(=O)OR, -CH 2 OC(=O)R, -CH 2 C(=O)NR 2, -CH 2 N C(=O)R, -S(=O) 2 R, -S(=O) 2 NR 2 and -N S(=O) 2 R.