A compound of formula or (Ia), or a pharmaceutically acceptable salt thereof: wherein Y is NR 3 or CR 3a R 3b; L 1 is an unsubstituted alkylene, substituted alkylene, bond, or substituted or unsubstituted heteroalkylene; R 1 is unsubstituted heteroaryl, substituted heteroaryl, hydrogen, oxo, halogen,-CX 3, -CN, -SO 2 Cl, -SO n R 10, -SO v NR 7 R 8, -NHNH 2, -ONR 7 R 8, -NHC NHNH 2, -NHC NR 7 R 8, -N m, -NR 7 R 8, -C R 9, -C OR 9, -C NR 7 R 8, -OR 10, -NR 7 SO 2 R 10,-N(R 7)C R 9, -NR 7 C -OR 9, -NR 7 OR 9, -OCX 3, -OCHX 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; R 2 is hydrogen; R 3 is unsubstituted alkyl, substituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3a and R 3b are independently hydrogen, halogen, -CF 3, -CCl 3, -CBr 3, -CI 3, -CN,-OH, -NH 2, -COOH, -CONH 2, -NO 2, -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3,-OCHF 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7, R 8, R 9, and R 10 are independently hydrogen, halogen, -CF 3, -CN, -OH, -NH 2,-COOH, -CONH 2, -NO 2, -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3,-OCHF 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; where R 7 and R 8 are bonded to the same nitrogen atom, they may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; m and v are independently 1 or 2; n is independently an integer from 0 to 4; X is independently -Cl, -Br, -I, or -F; for use in: treating a neurodegenerative disease or a cardiomyopathy in a patient. Y is NR 3 or CR 3a R 3b; L 1 is an unsubstituted alkylene, substituted alkylene, bond, or substituted or unsubstituted heteroalkylene; R 1 is unsubstituted heteroaryl, substituted heteroaryl, hydrogen, oxo, halogen,-CX 3, -CN, -SO 2 Cl, -SO n R 10, -SO v NR 7 R 8, -NHNH 2, -ONR 7 R 8, -NHC NHNH 2, -NHC NR 7 R 8, -N m, -NR 7 R 8, -C R 9, -C OR 9, -C NR 7 R 8, -OR 10, -NR 7 SO 2 R 10,-N(R 7)C R 9, -NR 7 C -OR 9, -NR 7 OR 9, -OCX 3, -OCHX 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; R 2 is hydrogen; R 3 is unsubstituted alkyl, substituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3a and R 3b are independently hydrogen, halogen, -CF 3, -CCl 3, -CBr 3, -CI 3, -CN,-OH, -NH 2, -COOH, -CONH 2, -NO 2, -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3,-OCHF 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7, R 8, R 9, and R 10 are independently hydrogen, halogen, -CF 3, -CN, -OH, -NH 2,-COOH, -CONH 2, -NO 2, -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3,-OCHF 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; where R 7 and R 8 are bonded to the same nitrogen atom, they may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; m and v are independently 1 or 2; n is independently an integer from 0 to 4; X is independently -Cl, -Br, -I, or -F; for use in: treating a neurodegenerative disease or a cardiomyopathy in a patient.