A neuromodulation system, comprising: a lead having at least one electrode adapted for implantation in or near a target neural structure in the brain; a signal generator selectively coupled to one or more of the at least one electrode and configured to: generate and apply a first stimulus to one or more of the at least one electrode, the first stimulus comprising a first plurality of bursts of stimulation; and generate and apply a second stimulus to one or more of the at least one electrode, the second stimulus comprising a second plurality of bursts of stimulation; a measurement device selectively coupled to one or more of the at least one electrode and configured to detect high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz generated from neural activity at one or more of the at least one electrode when implanted in the brain at least partially during application of the first stimulus; and a processing unit coupled to the measurement device and configured to determine one or more waveform characteristics of the detected HFOs, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs, wherein one or more of the first plurality of bursts comprises one of: a) a symmetric waveform having a first phase and a second phase of opposite polarity to the first phase; and b) a biphasic waveform having a first phase at a first amplitude for a first duration and a second phase of opposite polarity to the first phase, the second phase having a second amplitude and a second duration, the product of the first amplitude and the first duration being substantially equal to the product of the second amplitude and the second duration. a lead having at least one electrode adapted for implantation in or near a target neural structure in the brain; a signal generator selectively coupled to one or more of the at least one electrode and configured to: generate and apply a first stimulus to one or more of the at least one electrode, the first stimulus comprising a first plurality of bursts of stimulation; and generate and apply a second stimulus to one or more of the at least one electrode, the second stimulus comprising a second plurality of bursts of stimulation; generate and apply a first stimulus to one or more of the at least one electrode, the first stimulus comprising a first plurality of bursts of stimulation; and generate and apply a second stimulus to one or more of the at least one electrode, the second stimulus comprising a second plurality of bursts of stimulation; a measurement device selectively coupled to one or more of the at least one electrode and configured to detect high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz generated from neural activity at one or more of the at least one electrode when implanted in the brain at least partially during application of the first stimulus; and a processing unit coupled to the measurement device and configured to determine one or more waveform characteristics of the detected HFOs, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs, wherein one or more of the first plurality of bursts comprises one of: a) a symmetric waveform having a first phase and a second phase of opposite polarity to the first phase; and b) a biphasic waveform having a first phase at a first amplitude for a first duration and a second phase of opposite polarity to the first phase, the second phase having a second amplitude and a second duration, the product of the first amplitude and the first duration being substantially equal to the product of the second amplitude and the second duration. a) a symmetric waveform having a first phase and a second phase of opposite polarity to the first phase; and b) a biphasic waveform having a first phase at a first amplitude for a first duration and a second phase of opposite polarity to the first phase, the second phase having a second amplitude and a second duration, the product of the first amplitude and the first duration being substantially equal to the product of the second amplitude and the second duration.