A one pot process for preparing a 6-hydroxyl nal-opiate from a 6-keto nor-opiate, the process comprising: (a) contacting the 6-keto nor-opiate with an alkylating reagent to form a 6-keto nal-opiate, wherein the 6-keto nal-opiate is not isolated; and (b) contacting the 6-keto nal-opiate with a reducing agent and a proton acceptor to form the 6-hydroxyl nal-opiate, wherein the reducing agent is chosen from a hydrosulphite, a sulfinic acid reducing agent, and a borohydride reagent, and wherein the 6-hydroxyl nal-opiate comprises Formula, the 6-keto nor-opiate comprises Formula and the 6-keto nal-opiate comprises Formula as shown in the following reaction scheme: wherein: R 1, R 2, and R 3 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812; R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812, wherein any pair of R #a and R #b where # is chosen from 7, 8, 10, 15, and 16 may be optionally linked by groups chosen from =O, =S, and =NR 1813; R 17 is chosen from hydrocarbyl or substituted hydrocarbyl; R 1811, R 1812, and R 1813 are independently chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; the dashed lines between the C-7 and C-8 carbons represent a carbon- carbon double bond or a carbon-carbon single bond, provided that if there is a double bond between the C-7 and C-8 carbons then only one of R 7a and R 7b is present and only one of R 8a or R 8b is present; and provided that one or more of R 1 R 2, R 3, R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b may be linked to form carbocyclic or heterocyclic rings. (a) contacting the 6-keto nor-opiate with an alkylating reagent to form a 6-keto nal-opiate, wherein the 6-keto nal-opiate is not isolated; and (b) contacting the 6-keto nal-opiate with a reducing agent and a proton acceptor to form the 6-hydroxyl nal-opiate, wherein the reducing agent is chosen from a hydrosulphite, a sulfinic acid reducing agent, and a borohydride reagent, and wherein the 6-hydroxyl nal-opiate comprises Formula, the 6-keto nor-opiate comprises Formula and the 6-keto nal-opiate comprises Formula as shown in the following reaction scheme: wherein: R 1, R 2, and R 3 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812; R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812, wherein any pair of R #a and R #b where # is chosen from 7, 8, 10, 15, and 16 may be optionally linked by groups chosen from =O, =S, and =NR 1813; R 17 is chosen from hydrocarbyl or substituted hydrocarbyl; R 1811, R 1812, and R 1813 are independently chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; the dashed lines between the C-7 and C-8 carbons represent a carbon- carbon double bond or a carbon-carbon single bond, provided that if there is a double bond between the C-7 and C-8 carbons then only one of R 7a and R 7b is present and only one of R 8a or R 8b is present; and provided that one or more of R 1 R 2, R 3, R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b may be linked to form carbocyclic or heterocyclic rings. R 1, R 2, and R 3 are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812; R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b are independently chosen from hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, hydroxyl, SH, SR 1811, OR 1811, and NR 1811 R 1812, wherein any pair of R #a and R #b where # is chosen from 7, 8, 10, 15, and 16 may be optionally linked by groups chosen from =O, =S, and =NR 1813; R 17 is chosen from hydrocarbyl or substituted hydrocarbyl; R 1811, R 1812, and R 1813 are independently chosen from hydrogen, hydrocarbyl, and substituted hydrocarbyl; the dashed lines between the C-7 and C-8 carbons represent a carbon- carbon double bond or a carbon-carbon single bond, provided that if there is a double bond between the C-7 and C-8 carbons then only one of R 7a and R 7b is present and only one of R 8a or R 8b is present; and provided that one or more of R 1 R 2, R 3, R 5, R 7a, R 7b, R 8a, R 8b, R 9, R 10a, R 10b, R 14, R 15a, R 15b, R 16a, and R 16b may be linked to form carbocyclic or heterocyclic rings.