A system configured to control light exposure for circadian phase management and/or light deficient disorders of a subject, the system comprising: a user interface (126, 426); one or more physiological sensors (108, 208) configured to generate output signals conveying physiological data of the subject, wherein the one or more physiological sensors comprise a pupillometry sensor; a light control valve (114, 214) configured to block or reduce blue light ambient radiation reaching eyes of the subject; one or more radiation generators (112, 212) configured to generate therapeutic light radiation onto the eyes of the subject; and one or more processors (102, 202) in communication with the user interface, the one or more physiological sensors, the light control valve (114, 214), and the one or more radiation generators, the one or more processors causing the system to: receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve (114, 214) to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan. a user interface (126, 426); one or more physiological sensors (108, 208) configured to generate output signals conveying physiological data of the subject, wherein the one or more physiological sensors comprise a pupillometry sensor; a light control valve (114, 214) configured to block or reduce blue light ambient radiation reaching eyes of the subject; one or more radiation generators (112, 212) configured to generate therapeutic light radiation onto the eyes of the subject; and one or more processors (102, 202) in communication with the user interface, the one or more physiological sensors, the light control valve (114, 214), and the one or more radiation generators, the one or more processors causing the system to: receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve (114, 214) to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan. receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve (114, 214) to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan.