Automatic sampling method for non-homogenous biological sample contained in a container, such as a collection tube, said automatic sampling method comprising the following steps: - (step 101) providing a device comprising at least one pipetting unit equipped with at least one pipette with a tip, a control unit cooperating and controlling the pipetting unit, - (step 103) loading a container containing the non-homogenous biological sample inside the device, - (step 104) starting automatic homogenization inside the device, of said non-homogenous biological sample, said homogenization comprising the following substeps: • (104.1) the tip of the pipette dives into the container at a first predetermined depth under the surface of the non-homogenous biological sample, • (104.2) the pipette operates a plurality of cycles of aspirating and dispensing said non-homogenous biological sample into the container, wherein in each cycle the pipette aspirates the non-homogenous biological sample at the first predetermined depth, aspirating the whole volume capacity of the tip and then dispensing it back inside the container, the tip end of the pipette is being kept under the surface of the non-homogenous biological sample at the first predetermined depth during the plurality of cycles, - (step 106) sampling a predetermined volume of non-homogenous biological sample once the plurality of cycles is over, by: • a first phase (106.1) of aspirating the predetermined volume of non-homogenous biological sample from the container, wherein the tip is immerged at the first predetermined depth and • a second phase (106.2) of dispensing the predetermined volume previously aspirated, in a well distinct from the container containing the non-homogenous biological sample - (step 101) providing a device comprising at least one pipetting unit equipped with at least one pipette with a tip, a control unit cooperating and controlling the pipetting unit, - (step 103) loading a container containing the non-homogenous biological sample inside the device, - (step 104) starting automatic homogenization inside the device, of said non-homogenous biological sample, said homogenization comprising the following substeps: • (104.1) the tip of the pipette dives into the container at a first predetermined depth under the surface of the non-homogenous biological sample, • (104.2) the pipette operates a plurality of cycles of aspirating and dispensing said non-homogenous biological sample into the container, wherein in each cycle the pipette aspirates the non-homogenous biological sample at the first predetermined depth, aspirating the whole volume capacity of the tip and then dispensing it back inside the container, the tip end of the pipette is being kept under the surface of the non-homogenous biological sample at the first predetermined depth during the plurality of cycles, • (104.1) the tip of the pipette dives into the container at a first predetermined depth under the surface of the non-homogenous biological sample, • (104.2) the pipette operates a plurality of cycles of aspirating and dispensing said non-homogenous biological sample into the container, wherein in each cycle the pipette aspirates the non-homogenous biological sample at the first predetermined depth, aspirating the whole volume capacity of the tip and then dispensing it back inside the container, the tip end of the pipette is being kept under the surface of the non-homogenous biological sample at the first predetermined depth during the plurality of cycles, - (step 106) sampling a predetermined volume of non-homogenous biological sample once the plurality of cycles is over, by: • a first phase (106.1) of aspirating the predetermined volume of non-homogenous biological sample from the container, wherein the tip is immerged at the first predetermined depth and • a second phase (106.2) of dispensing the predetermined volume previously aspirated, in a well distinct from the container containing the non-homogenous biological sample • a first phase (106.1) of aspirating the predetermined volume of non-homogenous biological sample from the container, wherein the tip is immerged at the first predetermined depth and • a second phase (106.2) of dispensing the predetermined volume previously aspirated, in a well distinct from the container containing the non-homogenous biological sample