A process for the preparation of a compound of formula wherein W is selected from the group consisting of and each R 4 is independently selected from the group consisting of hydrogen, F, Cl, Br, I, -OH, -OCH 3, -OCH 2 CH 3, -SC alkyl, -SOC alkyl, -SO 2 C alkyl, -C alkyl, -CO 2 R d, -CONR e R f, -CCR g and -CN; wherein R d is selected from the group consisting of H and -C alkyl; R e is selected from the group consisting of H and -C alkyl; R f is selected from the group consisting of H and -C alkyl; and R g is selected from the group consisting of hydrogen, -CH 2 OH and -CH 2 CH 2 OH; J is selected from the group consisting of CH and N; R 2 is selected from the group consisting of cycloalkyl, spiro-substituted cycloalkenyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl and dihydropyranyl; any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, and C alkyl; Z is selected from the group consisting of hydrogen, F, Cl and CH 3; X is selected from the group consisting of wherein R w is selected from the group consisting of hydrogen, -C alkyl, -CO 2 C alkyl, -CONH 2, -CONHC alkyl, -CON(C alkyl) 2 and -COC alkyl; or a tautomer or pharmaceutically acceptable salt thereof; comprising reacting a compound of formula with a compound of formula or a mixture of SEM protected region-isomers thereof, wherein is selected from the group consisting of in the presence of carbon monoxide gas or a source of carbon monoxide; in the presence of an organic or inorganic base; in the presence of a suitably selected coupling system comprising a palladium compound and a ligand; in an organic solvent; at a temperature in the range of from about 60°C to about 120°C to yield the corresponding compound of formula; de-protecting the compound of formula, to yield the corresponding compound of formula, wherein the ligand is XantPhos. W is selected from the group consisting of and each R 4 is independently selected from the group consisting of hydrogen, F, Cl, Br, I, -OH, -OCH 3, -OCH 2 CH 3, -SC alkyl, -SOC alkyl, -SO 2 C alkyl, -C alkyl, -CO 2 R d, -CONR e R f, -CCR g and -CN; wherein R d is selected from the group consisting of H and -C alkyl; R e is selected from the group consisting of H and -C alkyl; R f is selected from the group consisting of H and -C alkyl; and R g is selected from the group consisting of hydrogen, -CH 2 OH and -CH 2 CH 2 OH; J is selected from the group consisting of CH and N; R 2 is selected from the group consisting of cycloalkyl, spiro-substituted cycloalkenyl, thiophenyl, dihydrosulfonopyranyl, phenyl, furanyl, tetrahydropyridyl and dihydropyranyl; any of which may be independently substituted with one or two of each of the following: chloro, fluoro, hydroxy, and C alkyl; Z is selected from the group consisting of hydrogen, F, Cl and CH 3; X is selected from the group consisting of wherein R w is selected from the group consisting of hydrogen, -C alkyl, -CO 2 C alkyl, -CONH 2, -CONHC alkyl, -CON(C alkyl) 2 and -COC alkyl; or a tautomer or pharmaceutically acceptable salt thereof; comprising reacting a compound of formula with a compound of formula or a mixture of SEM protected region-isomers thereof, wherein is selected from the group consisting of in the presence of carbon monoxide gas or a source of carbon monoxide; in the presence of an organic or inorganic base; in the presence of a suitably selected coupling system comprising a palladium compound and a ligand; in an organic solvent; at a temperature in the range of from about 60°C to about 120°C to yield the corresponding compound of formula; de-protecting the compound of formula, to yield the corresponding compound of formula, wherein the ligand is XantPhos.