mhurhangee/ep-ind-claims huggingface dataset:
A double-stranded iRNA agent with increased RNAi silencing activity, wherein the iRNA agent comprises two 21 nucleotide-long strands, wherein the strands form a double-stranded region of 19 consecutive base pairs having a two-nucleotide overhang at the 3'-end, wherein the cleavage site region corresponds to positions 9-12 from the 5'-end of the sense strand, said double-stranded iRNA agent comprising: a. an antisense strand that is complementary to a target gene; and b. a sense strand that is complementary to said antisense strand and comprises at least one of the following modified nucleotides in the following positions from the 5' end: (i) a ribonebularine in position 9; (ii) a ribo-2-aminopurine in position 12; and (iii) an abasic nucleotide in position 10. a. an antisense strand that is complementary to a target gene; and b. a sense strand that is complementary to said antisense strand and comprises at least one of the following modified nucleotides in the following positions from the 5' end: (i) a ribonebularine in position 9; (ii) a ribo-2-aminopurine in position 12; and (iii) an abasic nucleotide in position 10. (i) a ribonebularine in position 9; (ii) a ribo-2-aminopurine in position 12; and (iii) an abasic nucleotide in position 10.
A method of forming a layer of an electronic device, the method comprising the step of depositing a precursor layer comprising a compound of formula and reacting the compound of formula in a ring-opening addition reaction: Core-(Reactive Group) n wherein Core is a non-polymeric core group; and each Reactive Group, which may be the same or different in each occurrence, is a group of formula: wherein: Sp 1 independently in each occurrence represents a spacer group; w independently in each occurrence is 0 or 1; Ar in each occurrence independently represents an aryl or heteroaryl group that is unsubstituted or substituted with one or more substituents; R 1 in each occurrence independently represents H or a substituent, with the proviso that at least one R 1 is selected from the group consisting of linear or branched C 1-20 alkyl; C 1-20 alkoxy; and silyl; n is at least 1; and * is a point of attachment of the group of formula to the Core; and wherein the compound of formula reacts with itself or with a non-polymeric co-reactant. Sp 1 independently in each occurrence represents a spacer group; w independently in each occurrence is 0 or 1; Ar in each occurrence independently represents an aryl or heteroaryl group that is unsubstituted or substituted with one or more substituents; R 1 in each occurrence independently represents H or a substituent, with the proviso that at least one R 1 is selected from the group consisting of linear or branched C 1-20 alkyl; C 1-20 alkoxy; and silyl; n is at least 1; and * is a point of attachment of the group of formula to the Core; and wherein the compound of formula reacts with itself or with a non-polymeric co-reactant.
A filter apparatus for fluids, especially for low-viscosity liquids such as water, having a filter housing in which element holders for a plurality of filter elements are provided, the filter medium of said filter elements in the filter housing separating a dirty side from a clean side, wherein the filter housing can be opened to insert and remove the filter elements, wherein a carrier in the form of a basket is provided for the filter elements, said carrier being able to be inserted into and removed from the filter housing and detachably fixed to the filter elements, wherein the basket comprises a carrier plate, wherein the element holders for fixing filter elements in the form of filter tubes contain a connecting device (53, 55, 59, 61) which fixes a fluid-permeable support cylinder to the carrier plate such that an assigned filter tube can be pushed onto and removed from the outside of the support cylinder, characterised in that the carrier plate separates the dirty side from the clean side in the installation position in the housing and comprises fluid passages to form the element holders, the filter elements being able to be detachably fixed to said passages in such a way that the fluid passages are connected to the inner filter cavity which is surrounded by filter medium and in that the connecting device (53, 55, 59, 61) comprises a connecting rod anchored to each fluid passage, which extends through the support cylinder and comprises a screw fitting (57, 66) in the region of its free end to fix a holding plate, which extends over the end edge of the support cylinder and presses said support cylinder against the carrier plate.
A recombinant replication-competent gamma retroviral vector comprising: a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a pAC3-based retroviral polynucleotide comprising: Long-Terminal Repeat sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and cis-acting sequences necessary for reverse transcription, packaging and integration in a target cell, wherein the inhibitory nucleic acid sequence down regulate an immune inhibitory agent selected from PD-L1, IDO-1, and TGF-β 2 and wherein the LTR sequences, the promoter sequence, the gag nucleic acid domain, the pol nucleic acid domain, the env nucleic acid domain, and cis-acting sequences are retroviral sequences of corresponding pAC3 DNA sequences presented in SEQ ID NO:1 and 7-16. a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a pAC3-based retroviral polynucleotide comprising: Long-Terminal Repeat sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and cis-acting sequences necessary for reverse transcription, packaging and integration in a target cell, wherein the inhibitory nucleic acid sequence down regulate an immune inhibitory agent selected from PD-L1, IDO-1, and TGF-β 2 and wherein the LTR sequences, the promoter sequence, the gag nucleic acid domain, the pol nucleic acid domain, the env nucleic acid domain, and cis-acting sequences are retroviral sequences of corresponding pAC3 DNA sequences presented in SEQ ID NO:1 and 7-16.
Use of pentaethylenehexamine for production of polyurethane foams that are low-emission with regard to aldehyde, including formaldehyde, acetaldehyde, propionaldehyde, acrolein and benzaldehyde emissions.
Protective padding cap of a helmet made of a raw material solidified after being heated in a mould, the material before heating being composed in weight of 20-50% of expanded particles and 80-50% of binding component, the particles being made of plastic material, of closed shape, hollow and filled with gas, wherein the binding component comprises (i) non-expanded particles, in plastic material, of closed shape, hollow and filled with gas, characterized by the fact that the binding component further comprises (ii) a glue, and in that the raw material comprises 0-2% in weight of pyrogenic silica. (i) non-expanded particles, in plastic material, of closed shape, hollow and filled with gas, characterized by the fact that the binding component further comprises (ii) a glue,
A two-layer fabric for manufacturing unwoven fabric comprising a right surface side layer consisting of wefts of the right surface side and warps of the right surface side, and a back surface side layer consisting of wefts of the back surface side and warps of the back surface side, the two-layer fabric for manufacturing the unwoven fabric further comprises a first pair of warps (1Ub and 1Lb, 5Ub and 5Lb) in which a binding warp on the right surface side serving as a binding yarn and a binding warp on the back surface side serving as a binding yarn are arranged in a substantially vertical direction, a second pair of warps (2U and 2L, 3U and 3L, 6U and 6L, 7U and 7L) in which a warp on the right surface side and a warp on the back surface side are arranged in a vertical direction to be overlapped with each other, and a third pair of warps (4U and 4 L, 8U and 8L) in which two warps on the right surface side are arranged adjacent to each other, wherein in a perfect structure of said two-layer fabric for manufacturing the unwoven fabric includes sixteen warps, said sixteen warps comprises two sets of said first pairs of warps (1Ub and 1Lb, 5Ub and 5Lb), four sets of said second pair of warps (2U and 2L, 3U and 3L, 6U and 6L, 7U and 7L), and two sets of said third pair of warps (4U and 3L, 8U and 8L), characterised in that the diameters of the warps constituting said first pair of warps (1Ub and 1Lb, 5Ub and 5Lb), said second pair of warps (2U and 2L, 3U and 3L, 6U and 6L, 7U and 7L), and said third pair of warps (4U and 4 L, 8U and 8L) are between 0.30 mm and 0.50 mm, and the diameters of the wefts on the back surface side are between 0.30 mm and 0.70 mm, wherein no wefts are located between the upper surface side layer and the lower surface side layer.
A process for preparing fish bone powder comprising the following steps: a. removal of blood meat from the bone; b. pre-heating the bone at 80-120°C for 50-90 minutes; c. reducing the size of the bone obtained from step a or step b to 0.5-2 cm; d. washing the bone obtained from step c with water; e. removal of non-polar components from the bone obtained from step d with an alkali solution or with hexane, wherein the alkali concentration is in the range of 0.2-1% (w/v); f. removal of protein components from the bone obtained from step e with at least one enzyme, wherein the ratio between bone and water is in the range of 1:1-2; g. drying of the bone obtained from step f; and h. milling or pulverizing of the dried bone obtained from step g. a. removal of blood meat from the bone; b. pre-heating the bone at 80-120°C for 50-90 minutes; c. reducing the size of the bone obtained from step a or step b to 0.5-2 cm; d. washing the bone obtained from step c with water; e. removal of non-polar components from the bone obtained from step d with an alkali solution or with hexane, wherein the alkali concentration is in the range of 0.2-1% (w/v); f. removal of protein components from the bone obtained from step e with at least one enzyme, wherein the ratio between bone and water is in the range of 1:1-2; g. drying of the bone obtained from step f; and h. milling or pulverizing of the dried bone obtained from step g.
A process for the manufacture of an epoxy-functional polyester, comprising the steps of: a) providing a polyester having functional groups selected from hydroxyl groups and carboxylic acid groups; b) reacting the functional groups of the polyester with an epihaloalkane to obtain an epoxy-functional polyester dissolved in a liquid phase; c) optionally adding an organic solvent to the liquid phase obtained in step b); d) precipitating the epoxy-functional polyester from the liquid phase obtained in step b) or in step c); and e) isolating the precipitated epoxy-functional polyester from the liquid phase by a solid-liquid separation technique selected from filtration, centrifuge separation and decantation to obtain a solid epoxy-functional polyester. a) providing a polyester having functional groups selected from hydroxyl groups and carboxylic acid groups; b) reacting the functional groups of the polyester with an epihaloalkane to obtain an epoxy-functional polyester dissolved in a liquid phase; c) optionally adding an organic solvent to the liquid phase obtained in step b); d) precipitating the epoxy-functional polyester from the liquid phase obtained in step b) or in step c); and e) isolating the precipitated epoxy-functional polyester from the liquid phase by a solid-liquid separation technique selected from filtration, centrifuge separation and decantation to obtain a solid epoxy-functional polyester.
An automatic transmission control device for a hybrid vehicle including an engine, a motor, an automatic transmission that changes a speed of rotation of the engine and transmits the rotation to a drive shaft, and a clutch that releases or connects power transmission between the engine and the drive shaft, the automatic transmission control device comprising a control unit that controls the automatic transmission and the clutch to switch gear stages of the automatic transmission, wherein when performing a speed change of the automatic transmission while causing the motor to output a power generation torque to the drive shaft, the automatic transmission control device is characterized in that the control unit: starts a clutch releasing while maintaining the power generation torque to the drive shaft; and thereafter increases, if a clutch torque output from the automatic transmission decreases to a torque obtained by summing a maximum motor output torque and the power generation torque, a releasing speed of the clutch and causes the motor to output a speed-change assist torque. the automatic transmission control device comprising a control unit that controls the automatic transmission and the clutch to switch gear stages of the automatic transmission, wherein when performing a speed change of the automatic transmission while causing the motor to output a power generation torque to the drive shaft, the automatic transmission control device is characterized in that the control unit: starts a clutch releasing while maintaining the power generation torque to the drive shaft; and thereafter increases, if a clutch torque output from the automatic transmission decreases to a torque obtained by summing a maximum motor output torque and the power generation torque, a releasing speed of the clutch and causes the motor to output a speed-change assist torque. starts a clutch releasing while maintaining the power generation torque to the drive shaft; and thereafter increases, if a clutch torque output from the automatic transmission decreases to a torque obtained by summing a maximum motor output torque and the power generation torque, a releasing speed of the clutch and causes the motor to output a speed-change assist torque.
A suction-type portable atomizer, comprising a casing, a liquid storage case, an atomizing device and a power supply, wherein a first suction nozzle is disposed at one end of the casing; the liquid storage case is disposed within the casing and the liquid storage case has a storage cavity; one end of the liquid storage case is connected with the atomizing device which is connected with the power supply; the power supply comprises a housing and a fuel cell, a control circuit and a contact probe disposed in the housing; an output end of the control circuit is connected with the contact probe which is plugged into a contact conductor; the atomizing device comprises an atomizing assembly which includes a suction nozzle holder and a heater; one end of the suction nozzle holder is provided with an atomizing cavity, and the other end of the suction nozzle holder is provided with an air vent intercommunicating with the atomizing cavity; the heater is fixed into the atomizing cavity; the atomizing device further comprises a liquid guiding assembly which includes a second suction nozzle (322, 323); one end of the second suction nozzle (322, 323) is inserted into the storage cavity of the liquid storage case, such that liquid seal is formed at a contact part of the second suction nozzle (322, 323) and liquid storage case; the other end of the second suction nozzle (322, 323) intercommunicates with the atomizing cavity of the suction nozzle holder; characterized in that: the liquid guiding assembly further includes a liquid guiding rope; the liquid guiding rope is wound by the heater, and two ends of the liquid guiding rope are guided into the second suction nozzle (322, 323). the liquid guiding assembly further includes a liquid guiding rope; the liquid guiding rope is wound by the heater, and two ends of the liquid guiding rope are guided into the second suction nozzle (322, 323).
A rotor for a gas turbine engine, the rotor comprising rotor blades circumferentially distributed around and extending a full span length from a central hub, the rotor blades including alternating first and second rotor blades (28, 30), wherein the first rotor blades have a baseline profile, the second rotor blades have a modified profile being the same as the baseline profile but for a leading edge cutback, the leading edge cutback extends from a first span position to a second span position, wherein the first span position is located at a distance away from the hub not exceeding 90% of the total span length, the second span position is located at a distance away from the hub exceeding 50% of the total span length, characterized in that the first span position is located radially outwardly of a span location corresponding to a maximum deflection point for a selected natural vibration mode of a rotor blade having the baseline profile, wherein the selected natural vibration mode is a natural vibration mode higher than the 1 st natural vibration mode, and the second span position is located radially inwardly of the maximum deflection point, which is a location on the leading edge where an anti-node with a maximum deflection (AN-MD) is located for the selected natural vibration mode associated with flow induced resonance.
A method of imaging, the method comprising: projecting a reference onto an imaging detector by propagation of light generally along an optical axis extending from the reference, through an objective, to a surface of a sample holder, and from the surface, back through the objective, to the imaging detector, wherein the light propagates through an off-axis aperture located upstream of the imaging detector and spaced from the optical axis; capturing a plurality of images of the reference using the imaging detector, and with a correction optic at two or more different settings; selecting a setting for the correction optic based on the plurality of images; and imaging a sample while the correction optic has the selected setting. projecting a reference onto an imaging detector by propagation of light generally along an optical axis extending from the reference, through an objective, to a surface of a sample holder, and from the surface, back through the objective, to the imaging detector, wherein the light propagates through an off-axis aperture located upstream of the imaging detector and spaced from the optical axis; capturing a plurality of images of the reference using the imaging detector, and with a correction optic at two or more different settings; selecting a setting for the correction optic based on the plurality of images; and imaging a sample while the correction optic has the selected setting.
A system for use in downhole communication or detection comprising: a downhole arrangement defining a throughbore; a primary element (22, 122, 622, 722a, 722b, 722c); a deployable tool provided in the throughbore; and a plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578), wherein one of the primary element (22, 122, 622, 722a, 722b, 722c) and the plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) is provided on the downhole arrangement and the other of the primary element (22, 122, 622, 722a, 722b, 722c) and the plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) is provided on and extends circumferentially around the deployable tool, and the primary element (22, 122, 622, 722a, 722b, 722c) and each of the secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) are configurable for coupling of an electromagnetic field therebetween, wherein each secondary element extends around a different axis, each axis arranged along a different radial direction relative to a longitudinal axis of the downhole arrangement. a downhole arrangement defining a throughbore; a primary element (22, 122, 622, 722a, 722b, 722c); a deployable tool provided in the throughbore; and a plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578), wherein one of the primary element (22, 122, 622, 722a, 722b, 722c) and the plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) is provided on the downhole arrangement and the other of the primary element (22, 122, 622, 722a, 722b, 722c) and the plurality of secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) is provided on and extends circumferentially around the deployable tool, and the primary element (22, 122, 622, 722a, 722b, 722c) and each of the secondary elements (172, 174, 272, 274, 371-378, 471-478, 571-578) are configurable for coupling of an electromagnetic field therebetween, wherein each secondary element extends around a different axis, each axis arranged along a different radial direction relative to a longitudinal axis of the downhole arrangement.
Moist detergent wipe composed of a non-woven support impregnated with a detergent solution, the detergent solution comprising a protease, a lipase and an amylase, characterized in that the non-woven support consists of polyester fibers.