An isolated antibody, or antigen-binding fragment thereof, that binds to ANGPTL4 and that comprises both a heavy chain amino acid sequence and a light chain amino acid sequence selected from the group consisting of: (a) the heavy chain amino acid sequence of SEQ ID NO: 24 and the light chain amino acid sequence of SEQ ID NO: 2; (b) the heavy chain amino acid sequence of SEQ ID NO: 26 and the light chain amino acid sequence of SEQ ID NO: 7; (c) the heavy chain amino acid sequence of SEQ ID NO: 27 and the light chain amino acid sequence of SEQ ID NO: 3; (d) the heavy chain amino acid sequence of SEQ ID NO: 29 and the light chain amino acid sequence of SEQ ID NO: 10; (e) the heavy chain amino acid sequence of SEQ ID NO: 30 and the light chain amino acid sequence of SEQ ID NO: 9; (f) the heavy chain amino acid sequence of SEQ ID NO: 32 and the light chain amino acid sequence of SEQ ID NO: 14; (g) the heavy chain amino acid sequence of SEQ ID NO: 34 and the light chain amino acid sequence of SEQ ID NO: 6; (h) the heavy chain amino acid sequence of SEQ ID NO: 36 and the light chain amino acid sequence of SEQ ID NO: 4; (i) the heavy chain amino acid sequence of SEQ ID NO: 38 and the light chain amino acid sequence of SEQ ID NO: 16; (j) the heavy chain amino acid sequence of SEQ ID NO: 40 and the light chain amino acid sequence of SEQ ID NO: 18; (k) the heavy chain amino acid sequence of SEQ ID NO: 44 and the light chain amino acid sequence of SEQ ID NO: 19; (l) the heavy chain amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence of SEQ ID NO: 22; (m) the heavy chain amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence of SEQ ID NO: 21; (n) the heavy chain amino acid sequence of SEQ ID NO: 51 and the light chain amino acid sequence of SEQ ID NO: 12; and (o) the heavy chain amino acid sequence of SEQ ID NO: 53 and the light chain amino acid sequence of SEQ ID NO: 5. (a) the heavy chain amino acid sequence of SEQ ID NO: 24 and the light chain amino acid sequence of SEQ ID NO: 2; (b) the heavy chain amino acid sequence of SEQ ID NO: 26 and the light chain amino acid sequence of SEQ ID NO: 7; (c) the heavy chain amino acid sequence of SEQ ID NO: 27 and the light chain amino acid sequence of SEQ ID NO: 3; (d) the heavy chain amino acid sequence of SEQ ID NO: 29 and the light chain amino acid sequence of SEQ ID NO: 10; (e) the heavy chain amino acid sequence of SEQ ID NO: 30 and the light chain amino acid sequence of SEQ ID NO: 9; (f) the heavy chain amino acid sequence of SEQ ID NO: 32 and the light chain amino acid sequence of SEQ ID NO: 14; (g) the heavy chain amino acid sequence of SEQ ID NO: 34 and the light chain amino acid sequence of SEQ ID NO: 6; (h) the heavy chain amino acid sequence of SEQ ID NO: 36 and the light chain amino acid sequence of SEQ ID NO: 4; (i) the heavy chain amino acid sequence of SEQ ID NO: 38 and the light chain amino acid sequence of SEQ ID NO: 16; (j) the heavy chain amino acid sequence of SEQ ID NO: 40 and the light chain amino acid sequence of SEQ ID NO: 18; (k) the heavy chain amino acid sequence of SEQ ID NO: 44 and the light chain amino acid sequence of SEQ ID NO: 19; (l) the heavy chain amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence of SEQ ID NO: 22; (m) the heavy chain amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence of SEQ ID NO: 21; (n) the heavy chain amino acid sequence of SEQ ID NO: 51 and the light chain amino acid sequence of SEQ ID NO: 12; and (o) the heavy chain amino acid sequence of SEQ ID NO: 53 and the light chain amino acid sequence of SEQ ID NO: 5.