A biopsy device, comprising: a cannula comprising an elongate cannula body extending between a cannula distal end and a cannula proximal end to define a lumen, wherein the cannula comprises a cutting portion at the cannula distal end; a stylet comprising an elongate body having a stylet distal end and a stylet proximal end, the stylet being slidably disposed within the lumen, wherein the stylet comprises a tissue sampling portion, the tissue sampling portion being formed by a notch in the body of the stylet at or near the stylet distal end; an actuator assembly, the actuator assembly arranged to move the cannula relative to the stylet between a retracted position in which at least part of the tissue sampling portion is exposed and an extended position in which the cannula at least partly surrounds the tissue sampling portion, the actuator assembly comprising: a cannula actuator moveable between a primed configuration and an actuated configuration to move the cannula between the retracted position and the extended position; and a stylet actuator configured to actuate movement of the stylet relative to the cannula; and a selective coupling mechanism, characterised in that the selective coupling mechanism is arranged to provide a selective coupling between the actuator assembly and the stylet, the selective coupling mechanism comprising a stylet coupler, the stylet coupler being movable between: a stylet coupled configuration in which the stylet is coupled to the actuator assembly whereby the stylet actuator is further configured to control or cause movement of the cannula actuator between the actuated and primed configurations; and a stylet uncoupled configuration in which the stylet is uncoupled from the actuator assembly whereby the stylet can be moved independently of the cannula actuator. a cannula comprising an elongate cannula body extending between a cannula distal end and a cannula proximal end to define a lumen, wherein the cannula comprises a cutting portion at the cannula distal end; a stylet comprising an elongate body having a stylet distal end and a stylet proximal end, the stylet being slidably disposed within the lumen, wherein the stylet comprises a tissue sampling portion, the tissue sampling portion being formed by a notch in the body of the stylet at or near the stylet distal end; an actuator assembly, the actuator assembly arranged to move the cannula relative to the stylet between a retracted position in which at least part of the tissue sampling portion is exposed and an extended position in which the cannula at least partly surrounds the tissue sampling portion, the actuator assembly comprising: a cannula actuator moveable between a primed configuration and an actuated configuration to move the cannula between the retracted position and the extended position; and a stylet actuator configured to actuate movement of the stylet relative to the cannula; and a selective coupling mechanism, characterised in that the selective coupling mechanism is arranged to provide a selective coupling between the actuator assembly and the stylet, the selective coupling mechanism comprising a stylet coupler, the stylet coupler being movable between: a stylet coupled configuration in which the stylet is coupled to the actuator assembly whereby the stylet actuator is further configured to control or cause movement of the cannula actuator between the actuated and primed configurations; and a stylet uncoupled configuration in which the stylet is uncoupled from the actuator assembly whereby the stylet can be moved independently of the cannula actuator. a cannula actuator moveable between a primed configuration and an actuated configuration to move the cannula between the retracted position and the extended position; and a stylet actuator configured to actuate movement of the stylet relative to the cannula; and a selective coupling mechanism, characterised in that the selective coupling mechanism is arranged to provide a selective coupling between the actuator assembly and the stylet, the selective coupling mechanism comprising a stylet coupler, the stylet coupler being movable between: a stylet coupled configuration in which the stylet is coupled to the actuator assembly whereby the stylet actuator is further configured to control or cause movement of the cannula actuator between the actuated and primed configurations; and a stylet uncoupled configuration in which the stylet is uncoupled from the actuator assembly whereby the stylet can be moved independently of the cannula actuator. a stylet coupled configuration in which the stylet is coupled to the actuator assembly whereby the stylet actuator is further configured to control or cause movement of the cannula actuator between the actuated and primed configurations; and a stylet uncoupled configuration in which the stylet is uncoupled from the actuator assembly whereby the stylet can be moved independently of the cannula actuator.