mhurhangee/ep-ind-claims huggingface dataset:
Method of manufacturing a dry composition comprising a therapeutically effective amount of a rhGH polymer prodrug and one or more lyoprotectants, wherein the growth hormone is transiently linked to a polymer carrier, the rhGH polymer prodrug having the chemical structure shown in, wherein HN-rhGH represents the rhGH residue attached to the transient linker; R1, R2, R3, R4, and R5 are selected independently from hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; PEG is a water-soluble polyethylene glycol polymer containing at least 50% by weight ethylene oxide units attached to the transient linker; n = 1 or 2; and X is selected from C1 to C8 alkyl or C1 to C12 heteroalkyl; the method comprising the steps of (i) admixing the rhGH polymer prodrug with trehalose dihydrate and succinic acid to yield a composition comprising rhGH polymer prodrug 10-300 mg/ml succinic acid 5-50 mM trehalose dihydrate 25-850 mg/ml, (ii) adjusting the pH of the composition of step (i) to a pH ranging from pH 4.5 to pH 5.5 with tris, (iii) transferring amounts of the mixture from step (i) equivalent to the desired number of dosages into suitable chambers of a container, (iv) drying the mixture, and (v) sealing the container; whereas the order of steps (ii) and (iii) may be changed. HN-rhGH represents the rhGH residue attached to the transient linker; R1, R2, R3, R4, and R5 are selected independently from hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; PEG is a water-soluble polyethylene glycol polymer containing at least 50% by weight ethylene oxide units attached to the transient linker; n = 1 or 2; and X is selected from C1 to C8 alkyl or C1 to C12 heteroalkyl; (i) admixing the rhGH polymer prodrug with trehalose dihydrate and succinic acid to yield a composition comprising rhGH polymer prodrug 10-300 mg/ml succinic acid 5-50 mM trehalose dihydrate 25-850 mg/ml, (ii) adjusting the pH of the composition of step (i) to a pH ranging from pH 4.5 to pH 5.5 with tris, (iii) transferring amounts of the mixture from step (i) equivalent to the desired number of dosages into suitable chambers of a container, (iv) drying the mixture, and (v) sealing the container;
An electroacoustic transducer comprising: an active element; and an acoustic coupling layer arranged to acoustically couple, in use, the active element to a fluid transmission medium, the electroacoustic transducer further comprising a cavity arranged between the active element and the acoustic coupling layer to receive a fluid; wherein in use, the fluid in said cavity comprises the fluid transmission medium, said fluid in said cavity is in fluid-communication with said fluid transmission medium, wherein the acoustic coupling layer comprises an acoustic meta-material having a periodic structure and an anti-reflective effect, whereby acoustic coupling of the electroacoustic transducer and the fluid transmission medium is improved. an active element; and an acoustic coupling layer arranged to acoustically couple, in use, the active element to a fluid transmission medium, the electroacoustic transducer further comprising a cavity arranged between the active element and the acoustic coupling layer to receive a fluid; wherein in use, the fluid in said cavity comprises the fluid transmission medium, said fluid in said cavity is in fluid-communication with said fluid transmission medium, wherein the acoustic coupling layer comprises an acoustic meta-material having a periodic structure and an anti-reflective effect, whereby acoustic coupling of the electroacoustic transducer and the fluid transmission medium is improved.
An interference control method for use in a communication system including a macro base station, a macro terminal communicating with the macro base station, a femto base station, and a femto terminal registered in the femto base station, the interference control method comprising the steps of: measuring reference signal received quality (RSRQ) of the femto base station and RSRQ of the macro base station at the macro terminal; transmitting a request for activating interference control, a difference value between the measured RSRQ of the femto base station and the RSRQ of the macro base station, and identification information of the femto base station from the macro terminal to the macro base station, if the difference value is greater than a predetermined first threshold value; transmitting an interference control activation request signaling to the femto base station specified by the identification information from the macro base station, based on the request, the difference value, and the identification information; and performing interference control at the femto base station based on the interference control activation request signaling. measuring reference signal received quality (RSRQ) of the femto base station and RSRQ of the macro base station at the macro terminal; transmitting a request for activating interference control, a difference value between the measured RSRQ of the femto base station and the RSRQ of the macro base station, and identification information of the femto base station from the macro terminal to the macro base station, if the difference value is greater than a predetermined first threshold value; transmitting an interference control activation request signaling to the femto base station specified by the identification information from the macro base station, based on the request, the difference value, and the identification information; and performing interference control at the femto base station based on the interference control activation request signaling.
A method for producing a co-molded article, the article comprising a first element having a top surface, an edge, and a protuberance with a base extending downward from the top surface, and a second element having an edge, an upper surface, and a lower surface, the method comprising the steps of: preparing a two-piece mold comprising a first mold portion and a second mold portion, the first mold portion defining a co-molding upper surface, and the second mold portion defining a co-molding mold cavity into which the first and second elements are received; placing into the second mold portion, the first element with the protuberance base in contact with the second mold portion; placing into the second mold portion, the second element on top of the first element; closing the first mold portion and second mold portion into abutting relationship thereby forming the second element into a chamber; introducing a fluid under pressure into the second element chamber to force the second element upper surface to conform to the shape of the co-molding upper surface, and the second element lower surface into conform to the shape of the first element top surface thereby to affix the first element to the second element; and applying energy to the mold to co-mold the first and second elements together, wherein the second mold portion is configured so as to avoid contact with a significant fraction of the protuberance other than the base. preparing a two-piece mold comprising a first mold portion and a second mold portion, the first mold portion defining a co-molding upper surface, and the second mold portion defining a co-molding mold cavity into which the first and second elements are received; placing into the second mold portion, the first element with the protuberance base in contact with the second mold portion; placing into the second mold portion, the second element on top of the first element; closing the first mold portion and second mold portion into abutting relationship thereby forming the second element into a chamber; introducing a fluid under pressure into the second element chamber to force the second element upper surface to conform to the shape of the co-molding upper surface, and the second element lower surface into conform to the shape of the first element top surface thereby to affix the first element to the second element; and applying energy to the mold to co-mold the first and second elements together, wherein the second mold portion is configured so as to avoid contact with a significant fraction of the protuberance other than the base.
An extended length tube structure comprising: a first ceramic tube segment having a first end and a second end and a second ceramic tube segment having a first end and a second end, the second end of the first ceramic tube segment being arranged to face the first end of the second ceramic tube segment, each of the first and second ceramic tube segments having an inner diameter and an outer diameter; a ceramic coupling component sinter bonded to the second end of the first tube segment and the first end of the second tube segment such that the first and second tube segments are arranged end to end to form a continuous tube structure, wherein each of the ceramic tube segments forms a seal with the coupling component, wherein the seal has at least one performance characteristic selected from the group consisting of: i) a Shear Strength not less than 25 MPa; ii) a Nitrogen Seal Performance of not greater than 10%; iii) a Helium Seal Performance of not greater than 10%; iv) a Vacuum Seal Performance of not greater than 10%, wherein each of the first ceramic tube segment, the second ceramic tube segment, and the coupling component comprise silicon carbide, and wherein the silicon carbide comprises a content of the silicon carbide greater than at least 91 wt%, and wherein the silicon carbide further comprises: a carbonized organic material in an amount no greater than 5.0 wt%; boron in an amount from at least 0.15 wt % to no greater than 3.0 wt%; additional carbon in an amount no greater than 1.0 wt%; and a predominantly equiaxed microstructure. a first ceramic tube segment having a first end and a second end and a second ceramic tube segment having a first end and a second end, the second end of the first ceramic tube segment being arranged to face the first end of the second ceramic tube segment, each of the first and second ceramic tube segments having an inner diameter and an outer diameter; a ceramic coupling component sinter bonded to the second end of the first tube segment and the first end of the second tube segment such that the first and second tube segments are arranged end to end to form a continuous tube structure, wherein each of the ceramic tube segments forms a seal with the coupling component, wherein the seal has at least one performance characteristic selected from the group consisting of: i) a Shear Strength not less than 25 MPa; ii) a Nitrogen Seal Performance of not greater than 10%; iii) a Helium Seal Performance of not greater than 10%; iv) a Vacuum Seal Performance of not greater than 10%, i) a Shear Strength not less than 25 MPa; ii) a Nitrogen Seal Performance of not greater than 10%; iii) a Helium Seal Performance of not greater than 10%; iv) a Vacuum Seal Performance of not greater than 10%,
A base plate for an ostomy appliance, comprising: a carrier layer having a distal surface and a proximal surface, an adhesive material provided on the proximal surface of the carrier layer and adapted to adhere the base plate to a peristomal skin surface around a stoma of a user, a removable protection element provided on at least a proximal surface of the adhesive material, a stoma-receiving opening extending through the carrier layer, the adhesive material and the removable protection element, characterised in that an uptake portion surrounding the stoma-receiving opening is provided on at least a proximal surface of the removable protection element and is configured to take up stomal effluents to prevent the adhesive material from being contaminated by stomal effluents, and further wherein at least the uptake portion is adapted to be removed when the base plate is in a desired position around the stoma. a carrier layer having a distal surface and a proximal surface, an adhesive material provided on the proximal surface of the carrier layer and adapted to adhere the base plate to a peristomal skin surface around a stoma of a user, a removable protection element provided on at least a proximal surface of the adhesive material, a stoma-receiving opening extending through the carrier layer, the adhesive material and the removable protection element, characterised in that an uptake portion surrounding the stoma-receiving opening is provided on at least a proximal surface of the removable protection element and is configured to take up stomal effluents to prevent the adhesive material from being contaminated by stomal effluents, and further wherein at least the uptake portion is adapted to be removed when the base plate is in a desired position around the stoma.
Cabinet comprising a drawer accommodated therein for receiving a waste container, the cabinet having vertical walls (4, 5) on the inside of which a lid is mounted, the lid being intended in particular for covering the top of the optionally present waste container when the waste container is retracted, the drawer also being movable on first drawer rails, characterised in that the lid is mounted in the cabinet by means of telescopic second extension rails (12, 13), in that a mounting profile (18, 19) for mounting a co-moving rail (14, 16) is attached, for example screwed, to the lid, in that the lid has two opposing peripheral edges (8, 9) which have recesses (10, 11) that are open towards the free side of the peripheral edges (8, 9), for supporting the lid on pin-like mounting elements, and in that the lid, in order to be optionally mounted by means of the telescopic extension rails (12, 13) or by means of the pin-like mounting elements, can be arranged turned by 180° about a central axis extending in the pull-out direction (r).
A method for tone-mapping an input picture by using a parametric tone-adjustment function defined over multiple ranges, at least one parameter of the tone-adjustment function being associated to each range, characterized in that the method comprises: - defining a non-linear tone adjustment function over at least one range according to a modulation value, and - determining a parameter (midTonesAdjustement) of said tone-adjustment function according to the modulation value, wherein the modulation value is responsive of a mid-tone level of the input picture determined from a black level and a white level, said levels being based on the content of the picture. - defining a non-linear tone adjustment function over at least one range according to a modulation value, and - determining a parameter (midTonesAdjustement) of said tone-adjustment function according to the modulation value,
Support assembly for a motor, the assembly comprising two coaxial rings, these being an inner ring able to accept one or more elements of said motor and an outer ring able to be fixed to a housing forming an element of the structure, the assembly comprising tilt-limiting means limiting the tilting of the inner ring with respect to the outer ring, these being a projecting element which projects out from a first of the two rings, to become housed in a housing space formed in the second of the two rings, and travel-reducing means (7, 22) reducing the travel of the projecting element inside said housing space, the assembly further comprising an uncoupling element which is inserted between the inner ring and the outer ring and extends around at least one of the projecting elements within each housing space in which it is engaged, said at least one associated travel-reducing means (7, 22) extending facing the part of the uncoupling element around said projecting element, the travel reducing means comprising two pegs (7, 22) arranging facing one another, projecting respectively from a wall defining said housing space to extend into said housing space facing a face of the projecting element, said two pegs (7, 22) extending into the housing space on either side of the projecting element relative to an axis substantially parallel to an axis of revolution of the first of the two rings, projecting from two opposite walls, characterized in that the opposite walls which axially delimit each housing space formed in the second of the two rings are pierced in a direction parallel to that of the axis of said second ring with a first open-ended orifice and with a second open-ended orifice respectively, so that a respective one of said two pegs (7, 22) can pass through them, and in that said first and second open-ended orifices (44, 45) are arranged in such a way that their surfaces lie, in their entirety, respectively facing two opposite parallel faces of the projecting element that is engaged in the housing space concerned.
Distance measuring device with a housing, with, arranged in the housing, at least one transmission unit for emitting a light-measurement signal, to be precise a laser beam, with at least one reception unit for receiving a measurement signal component reflected at a distant object, with at least one computer unit, with at least one sensor, which is arranged in the housing and by means of which at least one swivel angle (18, 24) of the light-measurement signal relative to at least one comparison value is detectable, with a stand receiver rotatably mounted in the housing about at least one axis, to be precise a swivel axis, by means of which stand receiver the housing is coupleable to a stand in the manner swivelable about at least this swivel axis, wherein the swivel angle (18, 24) of the housing relative to the stand is detectable at least by means of the sensor by way of the swivel angle of the stand holder, characterized in that, after selecting a specific program, the computer unit expects at least one second substitute path measured by means of the light-measurement signal in addition to a first substitute path measured by means of the light-measurement signal and it calculates a path, which was not directly detected, in any triangle by means of the two substitute paths (52, 54) and the swivel angle between the substitute paths (52, 54), wherein, during the program selection, an initial point, from which the substitute paths (52, 54) are measured, is displaced from an end face of the housing facing away from the transmission unit into a centre of the stand receptacle and the initial point lies at a point of intersection of the swivel axis and a straight line formed by the laser measurement signal.
A steel for a high-strength bolt containing: from 0.50 mass% to 0.65 mass% carbon, from 1.5 mass% to 2.5 mass% silicon, from 1.0 mass% to 1.4 mass% chromium, greater than 0 mass% to 0.4 mass% manganese, greater than 1.5 mass% to 1.65 mass% or less molybdenum, 0.03 mass% or less phosphorus and sulfur combined, and balance iron and inevitable impurities.
An optoelectronic sensor for detecting and determining the distance of objects in a monitored area, the sensor comprising a light transmitter for transmitting a transmitted light signal having a light pulse into the monitored area, a light receiver for generating a reception pulse from the light signal remitted or reflected by objects in the monitored area, and a control and evaluation unit for determining the distance of the object based on the reception pulse and using a pulse-based time-of-flight method, wherein a receiver circuit having a first receiving path in which the reception pulse excites an oscillation is arranged downstream of the light receiver, wherein the control and evaluation unit is configured to evaluate the oscillation signal that is generated by a reception pulse by means of the first receiving path in order to determine a reception point in time, characterized in that the receiver circuit comprises a second receiving path for direct readout, in which the receiving pulse itself, whose pulse shape is mapped as faithfully as possible in the second receiving path, is transferred to the control and evaluation unit, and a switching element for switching between the two receiving paths (44, 48) in order to offer a choice between the evaluation of the oscillation signal and the receiving pulse itself, the two receiving paths (44, 48) being allowed to share lines and components.
Method of estimating the drift of a solar radiation sensor, wherein said sensor is a pyranometer or a reference cell associated with photovoltaic panels, and wherein: the radiation measured (GMES) by this sensor in its conditions of use and a radiation model are taken into account, using instantaneous ratios (d, α) of measured radiation values (GMES) to values (GTEMP) given by the model, or of values (GTEMP) given by the model to measured radiation values (GMES); the model delivers an estimate of the radiation expected in the case of a clear sky and takes into account the geographic location of the sensor, the latter being located in the terrestrial atmosphere; the measured radiation (GMES) is compared with the expected radiation (GTEMP), delivered by the model, during periods corresponding to a clear sky; and the estimate of the sensor drift is calculated by taking into account prior estimates of the drift. the model delivers an estimate of the radiation expected in the case of a clear sky and takes into account the geographic location of the sensor, the latter being located in the terrestrial atmosphere; the measured radiation (GMES) is compared with the expected radiation (GTEMP), delivered by the model, during periods corresponding to a clear sky; and the estimate of the sensor drift is calculated by taking into account prior estimates of the drift.
A manufacturing method of a vitreous body surgical probe characterized by, after a distal part covering a plastic-working shaped tube is formed into a flat surface by subjecting one end of the plastic-working shaped tube serving as a probe body to plastic working, sealing the distal part by irradiating the distal part with an energy beam.