A method for classifying a diffuse large B-cell lymphoma (DLBCL) of a subject into a GCB-DLBCL or into a ABC-DLBCL comprising the step of determining the expression level of 10 genes in a tumor tissue sample obtained from the subject by performing a Reverse Transcriptase Multiplex Ligation dependent Probe Amplification (RT-MLPA) assay wherein the 10 genes are NEK6, IRF4, IGHM, LMO2, F0XP1, TNFRSF9, BCL6, TNFRSF13B, CCND2 and MYBL1, said method comprising the steps of i) preparing a cDNA sample from the tumor tissue sample, ii) incubating the cDNA sample of step i) with a mixture of at least 10 different pairs of probes specific of a target nucleic acid sequence of NEK6, IRF4, IGHM, LMO2, FOXP1, TNFRSF9, BCL6, TNFRSF13B, CCND2 and MYBL1, iii) ligating the first probe to the second probe of the pairs probes, iv) amplifying the ligated probes produced at step iii) and v) detecting and quantifying the amplicons produced at step iv), wherein the pair of probes consists of: - a first probe having - a target specific region complementary to the first segment of the target nucleic acid sequence and - a tail region at the 5' extremity of the target specific region which is non-complementary to said target nucleic acid sequence, - a second probe having - a target specific region complementary to the second segment of the target nucleic acid sequence and - a tail region at the 3' extremity of the target specific region which is non-complementary to said target nucleic acid sequence, wherein the pair of probes specific for NEK6 consists of a first probe which is SEQ ID NO:54 (GTGCCAGCAAGATCCAATCTAGACCTGTGCATCCTCCTGACCCACAG) and a second probe which is SEQ ID NO:55 (AGGCATCCCAACACGCTGTCTTTTCCAACCCTTAGGGAACCC); the pair of probes specific for IRF4 consists of a first probe which is SEQ ID NO:56 (GTGCCAGCAAGATCCAATCTAGATCTGCCGAAGCCTTGGCGTTCTCAG) and a second probe which is SEQ ID NO:57 (ACTGCCGGCTGCACATCTGCCTGTATCCAACCCTTAGGGAACCC); the pair of probes specific for IGHM consists of a first probe which is SEQ ID NO:58 (GTGCCAGCAAGATCCAATCTAGATGCGTCCTCCATGTGTGGCCCCG) and a second probe which is SEQ ID NO:59 (ATCAAGACACAGCCATCCGGGTCTTCTACTATCCAACCCTTAGGGAACCC); the pair of probes specific for LMO2 consists of a first probe which is SEQ ID NO:62 (GTGCCAGCAAGATCCAATCTAGACGGAAGCTCTGCCGGAGAGACTATCTCAG) and a second probe which is SEQ ID NO:63 (GCTTTTTGGGCAAGACGGTCTCTGCTACTATCCAACCCTTAGGGAACCC); the pair of probes specific for FOXP1 consists of a first probe which is SEQ ID NO:64 (GTGCCAGCAAGATCCAATCTAGACCCTTCCCCTTCAACCTCTTGCTCAAG) and a second probe which is SEQ ID NO:65 (GCATGATTCCAACAGAACTGCAGCAGCTACTACTACTCCAACCCTTAGGGAACCC); the pair of probes specific for TNFRSF9 consists of a first probe which is SEQ ID NO:66 (GTGCCAGCAAGATCCAATCTAGATACGGACCTGTGACATATGCAGGCAGTGTAAAG) and a second probe which is SEQ ID NO:67 (GTGTTTTCAGGACCAGGAAGGAGTGTTCCTACTCCAACCCTTAGGGAACCC); the pair of probes specific for BCL6 consists of a first probe which is SEQ ID NO:68 (GTGCCAGCAAGATCCAATCTAGATACTACTCATAAAACGGTCCTCATGGCCTGCAG) and a second probe which is SEQ ID NO:69 (TGGCCTGTTCTATAGCATCTTTACAGACCAGTTGTCCAACCCTTAGGGAACCC); the pair of probes specific for TNFRSF13B consists of a first probe which is SEQ ID NO:70 (GTGCCAGCAAGATCCAATCTAGATACTACTACTAGCGCACCTGTGCAGCCTTCTGCA) and a second probe which is SEQ ID NO:71 (GGTCACTCAGCTGCCGCAAGGAGCTACTACTACTACTCCAACCCTTAGGGAACCC); the pair of probes specific for CCND2 consists of a first probe which is SEQ ID NO:72 (GTGCCAGCAAGATCCAATCTAGATACTACTGACCTTCATTGCTCTGTGTGCCACCG) and a second probe which is SEQ ID NO:73 (ACTTTAAGTTTGCCATGTACCCACCGTCGATACTACTATCCAACCCTTAGGGAACCC); and the pair of probes specific for MYBL1 consists of a first probe which is SEQ ID NO:76 (GTGCCAGCAAGATCCAATCTAGACCAGAATTTGCAGAGACTCTAGAACTTATTGAAT CT) and a second probe which is SEQ ID NO:77 (GATCCTGTAGCATGGAGTGACGTTACCAGTTTTTACTACTTCCAACCCTTAGGGAACC C. - a first probe having - a target specific region complementary to the first segment of the target nucleic acid sequence and - a tail region at the 5' extremity of the target specific region which is non-complementary to said target nucleic acid sequence, - a target specific region complementary to the first segment of the target nucleic acid sequence and - a tail region at the 5' extremity of the target specific region which is non-complementary to said target nucleic acid sequence, - a second probe having - a target specific region complementary to the second segment of the target nucleic acid sequence and - a tail region at the 3' extremity of the target specific region which is non-complementary to said target nucleic acid sequence, - a target specific region complementary to the second segment of the target nucleic acid sequence and - a tail region at the 3' extremity of the target specific region which is non-complementary to said target nucleic acid sequence,