A robotic manipulator system for maneuvering an insertion tube, which is inserted to patient's body, of an existing flexible uretero-renoscope to a desired location within a target zone during a medical procedure, comprising; - at least one control unit capable of receiving an operator input, - at least one robotic manipulator, in communication with said control unit and responsive to said operator input, said robotic manipulator comprising, i. at least one controller, ii. a rotation mechanism in communication with said at least one controller by said input and being rotated about a longitudinal axis of the insertion tube, iii. a horizontal movement unit in communication with said at least one controller by said input and being displaced along a first path which is parallel or coincide with the longitudinal axis of the insertion tube, and iv. a deflection actuator capable of receiving a portion of the existing flexible uretero-renoscope, said deflection actuator being in communication with said at least one controller by said input and being displaced along a second path; wherein displacement of said deflection actuator along said second path causes deflection of a distal end of the existing flexible uretero-renoscope, - wherein said control unit comprises at least one control console and said control console comprises at least one display device for displaying system parameters, - wherein the robotic manipulator system comprises at least one laser fiber which is inserted through a working channel of the flexible uretero-renoscope, the system further comprising - a robotic arm of the robotic manipulator further comprises at least one laser fiber actuator for actuating said laser fiber, - and in that said laser fiber actuator comprises at least one laser fiber holder for holding a laser fiber connection adapter and at least one movement unit for moving said laser fiber holder with respect to the flexible uretero-renoscope, and - wherein an advancement distance of the laser fiber is indicated on the display device as the distance from a distal end of the flexible uretero-renoscope to the tip of the laser fiber during movement of the laser fiber actuator, and - wherein a foot pedal is provided to control emission of laser radiation, and software of the robotic manipulator controls the emission of the laser by controlling the foot pedal such that, when the surgeon presses the foot pedal for laser shooting, the robot does not enable the laser if the tip of the laser fiber is close to the distal end of the flexible uretero-renoscope to avoid any damage of the uretero-renoscope. - at least one control unit capable of receiving an operator input, - at least one robotic manipulator, in communication with said control unit and responsive to said operator input, said robotic manipulator comprising, i. at least one controller, ii. a rotation mechanism in communication with said at least one controller by said input and being rotated about a longitudinal axis of the insertion tube, iii. a horizontal movement unit in communication with said at least one controller by said input and being displaced along a first path which is parallel or coincide with the longitudinal axis of the insertion tube, and iv. a deflection actuator capable of receiving a portion of the existing flexible uretero-renoscope, said deflection actuator being in communication with said at least one controller by said input and being displaced along a second path; wherein displacement of said deflection actuator along said second path causes deflection of a distal end of the existing flexible uretero-renoscope, i. at least one controller, ii. a rotation mechanism in communication with said at least one controller by said input and being rotated about a longitudinal axis of the insertion tube, iii. a horizontal movement unit in communication with said at least one controller by said input and being displaced along a first path which is parallel or coincide with the longitudinal axis of the insertion tube, and iv. a deflection actuator capable of receiving a portion of the existing flexible uretero-renoscope, said deflection actuator being in communication with said at least one controller by said input and being displaced along a second path; - wherein said control unit comprises at least one control console and said control console comprises at least one display device for displaying system parameters, - wherein the robotic manipulator system comprises at least one laser fiber which is inserted through a working channel of the flexible uretero-renoscope, the system further comprising - a robotic arm of the robotic manipulator further comprises at least one laser fiber actuator for actuating said laser fiber, - and in that said laser fiber actuator comprises at least one laser fiber holder for holding a laser fiber connection adapter and at least one movement unit for moving said laser fiber holder with respect to the flexible uretero-renoscope, and - wherein an advancement distance of the laser fiber is indicated on the display device as the distance from a distal end of the flexible uretero-renoscope to the tip of the laser fiber during movement of the laser fiber actuator, and - wherein a foot pedal is provided to control emission of laser radiation, and software of the robotic manipulator controls the emission of the laser by controlling the foot pedal such that, when the surgeon presses the foot pedal for laser shooting, the robot does not enable the laser if the tip of the laser fiber is close to the distal end of the flexible uretero-renoscope to avoid any damage of the uretero-renoscope.