A pump cartridge for use in a peristaltic pumping system, comprising: a housing, a roller assembly within the housing, the roller assembly comprising first and second hubs maintained in a spaced apart relationship by one or more posts extending therebetween and defining a pump cartridge axis, and a plurality of planetary rollers mounted on, and extending longitudinally between, the first and second hubs, wherein the rollers are mounted in a circumferentially spaced orientation about the pump cartridge axis, each roller comprising a roller body defining a respective roller axis, characterized in that each roller has respective axles extending from opposite end surfaces of the roller body along the roller axis, wherein the roller axles are positioned in respective slots in, or associated with, the first and second hubs that are oriented substantially orthogonal to the roller axes so that the rollers may move in a radially outward direction away from the pump cartridge axis toward an interior wall of the housing by travel of the roller axles in the hub slots, the pump cartridge further comprises a barb assembly interposed between the interior wall of the housing and an outer radial periphery of the roller assembly, the barb assembly comprising one or more compressible tubing lines (242a, 242b, 242c), the housing has an opening through which a roller spreader extends when the pump cartridge is mounted on a pump console comprising the roller spreader, angular rotation of the roller spreader relative to the roller assembly displaces the roller bodies radially outward to thereby compress contacted portions of the one or more tubing lines (242a, 242b, 242c) against the interior wall of the housing, and the first hub is configured to engage a roller driving feature of the pump console so that rotation of the engaged driving feature causes rotation of the roller assembly about the pump cartridge axis. a housing, a roller assembly within the housing, the roller assembly comprising first and second hubs maintained in a spaced apart relationship by one or more posts extending therebetween and defining a pump cartridge axis, and a plurality of planetary rollers mounted on, and extending longitudinally between, the first and second hubs, wherein the rollers are mounted in a circumferentially spaced orientation about the pump cartridge axis, each roller comprising a roller body defining a respective roller axis, characterized in that each roller has respective axles extending from opposite end surfaces of the roller body along the roller axis, wherein the roller axles are positioned in respective slots in, or associated with, the first and second hubs that are oriented substantially orthogonal to the roller axes so that the rollers may move in a radially outward direction away from the pump cartridge axis toward an interior wall of the housing by travel of the roller axles in the hub slots, the pump cartridge further comprises a barb assembly interposed between the interior wall of the housing and an outer radial periphery of the roller assembly, the barb assembly comprising one or more compressible tubing lines (242a, 242b, 242c), the housing has an opening through which a roller spreader extends when the pump cartridge is mounted on a pump console comprising the roller spreader, angular rotation of the roller spreader relative to the roller assembly displaces the roller bodies radially outward to thereby compress contacted portions of the one or more tubing lines (242a, 242b, 242c) against the interior wall of the housing, and the first hub is configured to engage a roller driving feature of the pump console so that rotation of the engaged driving feature causes rotation of the roller assembly about the pump cartridge axis.