A vehicle central control antitheft method, comprising: performing, by a central control system, identity verification for a remote control via cipher matching; selecting, by the central control system, an alert status in response to a result of identity verification of the remote control, status of an ignition switch and an action of opening or closing a vehicle door, encrypting the selected alert status and transmitting the encrypted alert status to an engine management system, wherein the alert status is selected from an alarm activation status and an alarm inactivation status when the ignition switch of the vehicle is in the status ON, and is selected from a pre-alerting status, an alerting status, the alarm activation status, and the alarm inactivation status when the ignition switch of the vehicle is in the status OFF; determining by the engine management system, when the ignition switch is switched on, whether the encrypted alert status transmitted from the central control system is received; decrypting, by the engine management system, the encrypted alert status, if the encrypted alert status transmitted from the central control system is received; determining by the engine management system whether the decrypted alert status is the alarm inactivation status; performing safety authentication between the engine management system and the central control system via cipher matching in bidirectional encrypted communication in the case that the decrypted alert status is the alarm inactivation status; and locking or unlocking, by the engine management system, an engine in response to a result of safety authentication. performing, by a central control system, identity verification for a remote control via cipher matching; selecting, by the central control system, an alert status in response to a result of identity verification of the remote control, status of an ignition switch and an action of opening or closing a vehicle door, encrypting the selected alert status and transmitting the encrypted alert status to an engine management system, wherein the alert status is selected from an alarm activation status and an alarm inactivation status when the ignition switch of the vehicle is in the status ON, and is selected from a pre-alerting status, an alerting status, the alarm activation status, and the alarm inactivation status when the ignition switch of the vehicle is in the status OFF; determining by the engine management system, when the ignition switch is switched on, whether the encrypted alert status transmitted from the central control system is received; decrypting, by the engine management system, the encrypted alert status, if the encrypted alert status transmitted from the central control system is received; determining by the engine management system whether the decrypted alert status is the alarm inactivation status; performing safety authentication between the engine management system and the central control system via cipher matching in bidirectional encrypted communication in the case that the decrypted alert status is the alarm inactivation status; and locking or unlocking, by the engine management system, an engine in response to a result of safety authentication.