A portable ultrasound system, comprising: a user interface system comprising at least one display screen and at least one user input device; a main circuit board module comprising a processing circuit configured to perform general computing operations and configured to receive ultrasound imaging data from a removable ultrasound module; a housing containing the user interface system and the main circuit board module and having an opening configured to removably receive the removable ultrasound module; and a connector configured to form an electrical connection with a corresponding second connector of the removable ultrasound module when the removable ultrasound module is fully inserted into the portable ultrasound system through the opening of the housing, wherein the connector comprises at least one guiding feature configured to align the connector and the second connector as the removable ultrasound module is inserted into the portable ultrasound system; the portable ultrasound system is configured to provide electrical power to the removable ultrasound module, and receive the ultrasound imaging data from the removable ultrasound module; characterized in that the portable ultrasound system further comprises a release lever, and the release lever is configured to rotate around an axis parallel to a bottom face of the housing during ejecting the removable ultrasound module from the portable ultrasound system; the release lever comprises an interlock mechanism that is controlled by the main circuit board module; and the interlock mechanism is normally engaged to prevent removal of the removable ultrasound module, and the main circuit board module disengages the interlock mechanism when the main circuit board module determines that it is safe to remove the removable ultrasound module. a user interface system comprising at least one display screen and at least one user input device; a main circuit board module comprising a processing circuit configured to perform general computing operations and configured to receive ultrasound imaging data from a removable ultrasound module; a housing containing the user interface system and the main circuit board module and having an opening configured to removably receive the removable ultrasound module; and a connector configured to form an electrical connection with a corresponding second connector of the removable ultrasound module when the removable ultrasound module is fully inserted into the portable ultrasound system through the opening of the housing, wherein the connector comprises at least one guiding feature configured to align the connector and the second connector as the removable ultrasound module is inserted into the portable ultrasound system; the portable ultrasound system is configured to provide electrical power to the removable ultrasound module, and receive the ultrasound imaging data from the removable ultrasound module; characterized in that the portable ultrasound system further comprises a release lever, and the release lever is configured to rotate around an axis parallel to a bottom face of the housing during ejecting the removable ultrasound module from the portable ultrasound system; the release lever comprises an interlock mechanism that is controlled by the main circuit board module; and the interlock mechanism is normally engaged to prevent removal of the removable ultrasound module, and the main circuit board module disengages the interlock mechanism when the main circuit board module determines that it is safe to remove the removable ultrasound module.