A compound of general formula: in which X represents CH or N; Y represents CR 3 or N; Z represents CH or N, wherein if X represents N, Y represents CR 3 and Z represents CH, and if X represents CH, Z represents CH and Y represents CR 3 or N, and if Z represents N, Y represents N and X represents CH; R 1 represents C 2 -C 8 -hydroxyalkyl, wherein said C 2 -C 8 -hydroxyalkyl groups are optionally substituted once with R 7 and optionally one to three times with halogen, or C 3 -C 6 -cycloalkyl substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (C 3 -C 6 -cycloalkyl substituted once with hydroxy)-C 1 -C 4 -alkyl, or 5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy)-C 1 -C 4 -alkyl; R 2 represents hydrogen, chloro, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy, trifluoromethoxy or -NR 8 R 9; R 3 represents hydrogen, halogen or methyl; R 4 represents monocyclic heteroaryl optionally substituted one to three times, independently from each other, with R 5; R 5 represents C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, halogen or cyano; R 7 represents C 1 -C 4 -alkoxy, -CO 2 -R 10, -CO-NR 8 R 9, cyano, -NR 8 R 9, C 3 -C 6 -cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or monocyclic heteroaryl; R 8 and R 9 are the same or different and represent, independently from each other, hydrogen or C 1 -C 3 -alkyl, or together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, said ring optionally containing one additional heteroatom selected from O, S, NH, NR a in which R a represents a C 1 -C 4 -alkyl group; R 10 represents hydrogen or C 1 -C 4 -alkyl; their polymorphs, enantiomeres, diastereomeres, racemates, tautomeres, N-oxides, hydrates and solvates, as well as their physiological acceptable salts and solvates of these salts, as well as mixtures of the same. X represents CH or N; Y represents CR 3 or N; Z represents CH or N, wherein if X represents N, Y represents CR 3 and Z represents CH, and if X represents CH, Z represents CH and Y represents CR 3 or N, and if Z represents N, Y represents N and X represents CH; if X represents N, Y represents CR 3 and Z represents CH, and if X represents CH, Z represents CH and Y represents CR 3 or N, and if Z represents N, Y represents N and X represents CH; R 1 represents C 2 -C 8 -hydroxyalkyl, wherein said C 2 -C 8 -hydroxyalkyl groups are optionally substituted once with R 7 and optionally one to three times with halogen, or C 3 -C 6 -cycloalkyl substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (C 3 -C 6 -cycloalkyl substituted once with hydroxy)-C 1 -C 4 -alkyl, or 5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy)-C 1 -C 4 -alkyl; C 3 -C 6 -cycloalkyl substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (C 3 -C 6 -cycloalkyl substituted once with hydroxy)-C 1 -C 4 -alkyl, or 5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy or C 1 -C 3 -hydroxyalkyl and optionally one to three times with halogen, or (5- to 6-membered heterocycloalkyl optionally substituted once with hydroxy)-C 1 -C 4 -alkyl; R 2 represents hydrogen, chloro, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy, trifluoromethoxy or -NR 8 R 9; R 3 represents hydrogen, halogen or methyl; R 4 represents monocyclic heteroaryl optionally substituted one to three times, independently from each other, with R 5; R 5 represents C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkoxy, halogen or cyano; R 7 represents C 1 -C 4 -alkoxy, -CO 2 -R 10, -CO-NR 8 R 9, cyano, -NR 8 R 9, C 3 -C 6 -cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or monocyclic heteroaryl; R 8 and R 9 are the same or different and represent, independently from each other, hydrogen or C 1 -C 3 -alkyl, or together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, said ring optionally containing one additional heteroatom selected from O, S, NH, NR a in which R a represents a C 1 -C 4 -alkyl group; R 10 represents hydrogen or C 1 -C 4 -alkyl;