mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical composition for use in a method of the prevention or treatment of diabetes mellitus, comprising: a long-acting insulin analogue conjugate in which an insulin analogue is linked to an immunoglobulin Fc region via a non-peptidyl polymer linker; and a long-acting insulinotropic peptide conjugate in which an insulinotropic peptide is linked to an immunoglobulin Fc region via a non-peptidyl polymer linker, wherein the insulin analogue is characterized in substitution of the amino acid at position 14 of the A chain with glutamic acid, and wherein the insulinotropic peptide is an imidazo-acetyl exendin-4 (CA Exendin-4). a long-acting insulin analogue conjugate in which an insulin analogue is linked to an immunoglobulin Fc region via a non-peptidyl polymer linker; and a long-acting insulinotropic peptide conjugate in which an insulinotropic peptide is linked to an immunoglobulin Fc region via a non-peptidyl polymer linker, wherein the insulin analogue is characterized in substitution of the amino acid at position 14 of the A chain with glutamic acid, and wherein the insulinotropic peptide is an imidazo-acetyl exendin-4 (CA Exendin-4).
A subsea cutting assembly for handling and cutting subsea structures, comprising: a frame; first and second arms connected to the frame by a pivot, wherein the arms (30a, 30b) are adapted to transform between open and closed configurations by pivoting around the pivot; a blade movable with respect to the frame, wherein the blade is adapted to cut a subsea structure disposed between the first and second arms when the first and second arms are in a closed configuration around the subsea structure; each of the first and second arms comprise a first portion (31a, 31b) and a second portion (32a, 32b), the first (31a, 31b) and second (32a, 32b) portions each having an inner (34a, 34b) and outer (35a, 35b) face; wherein when the arms (30a, 30b) are in the closed configuration the inner faces (34a, 34b) of the first portions (31a, 31b) of each arm (30a, 30b) are parallel relative to one another; wherein the inner faces (34a, 34b) of the second portions (32a, 32b) of each arm (30a, 30b) are disposed at an angle of 90 degrees or less relative to the inner faces (34a, 34b) of the first portions (31a, 31b); and wherein the inner faces (34a, 34b) of the second portions (32a, 32b) of each arm (30a, 30b) are planar; characterised in that the inner faces (34a, 34b) of the first portions (31a, 31b) of the first and second arms (30a, 30b) incorporate a guide (38a, 38b) for the blade when the arms (30a, 30b) are closed around the structure to be cut. a frame; first and second arms connected to the frame by a pivot, wherein the arms (30a, 30b) are adapted to transform between open and closed configurations by pivoting around the pivot; a blade movable with respect to the frame, wherein the blade is adapted to cut a subsea structure disposed between the first and second arms when the first and second arms are in a closed configuration around the subsea structure; each of the first and second arms comprise a first portion (31a, 31b) and a second portion (32a, 32b), the first (31a, 31b) and second (32a, 32b) portions each having an inner (34a, 34b) and outer (35a, 35b) face; wherein when the arms (30a, 30b) are in the closed configuration the inner faces (34a, 34b) of the first portions (31a, 31b) of each arm (30a, 30b) are parallel relative to one another; wherein the inner faces (34a, 34b) of the second portions (32a, 32b) of each arm (30a, 30b) are disposed at an angle of 90 degrees or less relative to the inner faces (34a, 34b) of the first portions (31a, 31b); and wherein the inner faces (34a, 34b) of the second portions (32a, 32b) of each arm (30a, 30b) are planar; characterised in that the inner faces (34a, 34b) of the first portions (31a, 31b) of the first and second arms (30a, 30b) incorporate a guide (38a, 38b) for the blade when the arms (30a, 30b) are closed around the structure to be cut.
A liquid pharmaceutical formulation for injection comprising: (i) an antibody; (ii) thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole (TPP-APMI); and (iii) a pharmaceutically acceptable solvent; wherein the liquid pharmaceutical formulation, when in a volume suitable for injection: (a) has an absolute viscosity from about 1 mPa*s (cP) to about 100 mPa*s (cP) at 25°C as measured using a cone and plate viscometer or a microfluidic viscometer; and (b) the absolute viscosity of the liquid pharmaceutical formulation is less than an absolute viscosity of a corresponding composition comprising the antibody and the pharmaceutically acceptable solvent but without the TPP-APMI; wherein the absolute viscosity is an extrapolated zero-shear viscosity. (i) an antibody; (ii) thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole (TPP-APMI); and (iii) a pharmaceutically acceptable solvent; wherein the liquid pharmaceutical formulation, when in a volume suitable for injection: (a) has an absolute viscosity from about 1 mPa*s (cP) to about 100 mPa*s (cP) at 25°C as measured using a cone and plate viscometer or a microfluidic viscometer; and (b) the absolute viscosity of the liquid pharmaceutical formulation is less than an absolute viscosity of a corresponding composition comprising the antibody and the pharmaceutically acceptable solvent but without the TPP-APMI; (a) has an absolute viscosity from about 1 mPa*s (cP) to about 100 mPa*s (cP) at 25°C as measured using a cone and plate viscometer or a microfluidic viscometer; and (b) the absolute viscosity of the liquid pharmaceutical formulation is less than an absolute viscosity of a corresponding composition comprising the antibody and the pharmaceutically acceptable solvent but without the TPP-APMI; wherein the absolute viscosity is an extrapolated zero-shear viscosity.
A recoater for a three-dimensional printer for application of a material comprising: 1.1 a material reservoir with an opening for release of a material contained within the material reservoir; 1.2 a belt conveyor system with a conveyor belt with a top surface of the conveyor belt; 1.3 the belt conveyor system is adapted to receive the material via the opening from the material reservoir onto the top surface of the conveyor belt, such that a layer of material can be formed on the top surface of the conveyor belt; 1.4 whereas the belt conveyor system can be moved relatively with respect to the position of the material reservoir between a first and second location, characterized in that this movement at least comprises a horizontal component. 1.1 a material reservoir with an opening for release of a material contained within the material reservoir; 1.2 a belt conveyor system with a conveyor belt with a top surface of the conveyor belt; 1.3 the belt conveyor system is adapted to receive the material via the opening from the material reservoir onto the top surface of the conveyor belt, such that a layer of material can be formed on the top surface of the conveyor belt; 1.4 whereas the belt conveyor system can be moved relatively with respect to the position of the material reservoir between a first and second location, characterized in that this movement at least comprises a horizontal component.
An image processing apparatus that processes a radiation image captured by a radiography apparatus including a radiation source and a radiation detector, the image processing apparatus comprising: at least one processor that is configured to: acquire a first low-energy image and a first high-energy image of a subject captured by the radiography apparatus in a state in which a grid for removing scattered rays is inserted between the radiation source and the radiation detector, and the radiation source is disposed at a first position at which an incidence direction of the radiation is a normal direction with respect to the grid; acquire a second low-energy image and a second high-energy image of the subject captured by the radiography apparatus in a state in which the grid retreats from between the radiation source and the radiation detector, and the radiation source is disposed at a second position different from the first position; estimate a thickness of the subject from the first low-energy image and the first high-energy image; and generate a difference image indicating a difference between the second high-energy image and the second low-energy image from the second low-energy image and the second high-energy image based on the estimated thickness, wherein the first and second low-energy images are captured by emitting radiation having first energy from the radiation source to the subject into which a contrast medium has been injected, and the first and second high-energy images are captured by emitting radiation having second energy higher than the first energy from the radiation source to the subject into which the contrast medium has been injected. acquire a first low-energy image and a first high-energy image of a subject captured by the radiography apparatus in a state in which a grid for removing scattered rays is inserted between the radiation source and the radiation detector, and the radiation source is disposed at a first position at which an incidence direction of the radiation is a normal direction with respect to the grid; acquire a second low-energy image and a second high-energy image of the subject captured by the radiography apparatus in a state in which the grid retreats from between the radiation source and the radiation detector, and the radiation source is disposed at a second position different from the first position; estimate a thickness of the subject from the first low-energy image and the first high-energy image; and generate a difference image indicating a difference between the second high-energy image and the second low-energy image from the second low-energy image and the second high-energy image based on the estimated thickness, wherein the first and second low-energy images are captured by emitting radiation having first energy from the radiation source to the subject into which a contrast medium has been injected, and the first and second high-energy images are captured by emitting radiation having second energy higher than the first energy from the radiation source to the subject into which the contrast medium has been injected.
A testing device comprising: a first terminal and a second terminal configured to be connected to an equipment under test characterised by: a common-mode detector configured to detect a common-mode part of a signal emitted from said equipment under test by measuring a voltage drop at a measurement resistor connected between a common-mode output terminal and ground; and a first impedance unit connected in series between said first terminal and said common-mode detector; wherein said first impedance unit is configured to adjust a longitudinal conversion loss of said testing device to a predetermined value. a first terminal and a second terminal configured to be connected to an equipment under test characterised by: a common-mode detector configured to detect a common-mode part of a signal emitted from said equipment under test by measuring a voltage drop at a measurement resistor connected between a common-mode output terminal and ground; and a first impedance unit connected in series between said first terminal and said common-mode detector; wherein said first impedance unit is configured to adjust a longitudinal conversion loss of said testing device to a predetermined value. a common-mode detector configured to detect a common-mode part of a signal emitted from said equipment under test by measuring a voltage drop at a measurement resistor connected between a common-mode output terminal and ground; and a first impedance unit connected in series between said first terminal and said common-mode detector; wherein said first impedance unit is configured to adjust a longitudinal conversion loss of said testing device to a predetermined value.
A tensioning assembly for a process valve, comprising: - a housing having an interface for rigid connection to a valve body, - a gearing supported on the housing; and - a tensioning element arranged at the output of the gearing, the tensioning element comprising a contact surface which is designed to clamp a lateral outer collar of a diaphragm of the process valve between the tensioning element and the valve body, characterized by - a switchable coupling which transmits a torque introduced into the coupling either into a drive rod or into the gearing. - a housing having an interface for rigid connection to a valve body, - a gearing supported on the housing; and - a tensioning element arranged at the output of the gearing, the tensioning element comprising a contact surface which is designed to clamp a lateral outer collar of a diaphragm of the process valve between the tensioning element and the valve body, characterized by - a switchable coupling which transmits a torque introduced into the coupling either into a drive rod or into the gearing.
A submersible assembly comprising: (a) a support structure; and (b) a cabin pivotally coupled to the support structure and comprising an outer enclosure encapsulating an inner cabin, wherein the cabin is configured to rotate between a raised position above a surface of a body of water and a submerged position, wherein at least a portion of the cabin is below the surface of the body of water, and wherein the inner cabin is configured to maintain substantially the same attitude as the support structure when the cabin rotates between the raised position and the submerged position, and wherein the inner cabin comprises a platform; characterised in that the platform comprises wheels that are coupled to a pair of tracks positioned on an inner surface of the outer enclosure. (a) a support structure; and (b) a cabin pivotally coupled to the support structure and comprising an outer enclosure encapsulating an inner cabin,
Injection device having an integral housing element which extends along an axis, wherein an axial bore which extends along the axis is formed in the housing element, and wherein a piston which is displaceable along the axis is arranged in a first region of the axial bore, and an outlet valve is arranged in a second region of the axial bore, having an outer sleeve which surrounds the housing element along its circumference, such that a ring-shaped coolant chamber for accommodating a coolant is formed between the outer sleeve and the housing element; an inner sleeve which is arranged between the outer sleeve and at least that region of the housing element in which the first region of the axial bore is formed, such that, between the inner sleeve and the housing element, there is formed a coil chamber, in which an electrical coil is arranged.
A gas sensor housing, comprising: a gas sensor, for establishment of a gas concentration on an active surface of the gas sensor, held by a housing body below a primary gas permeable membrane; at least one connector element moulded into the housing body such that the respective ends thereof protrude from a bottom of the housing body and such that they reach a top of the housing body to enable connectivity to the gas sensor such that signals may be carried from the gas sensor to the connector element; a sensor envelope providing an enclosure for the housing body and having a first opening facing the top of the housing body to accommodate the primary gas permeable membrane, and a second opening facing the bottom of the housing body to accommodate the at least one connector element that protrudes from the bottom of the housing body; means for retaining the primary gas permeable membrane in place above the gas sensor; a spacer section providing a separation distance between the gas sensor and the primary gas permeable membrane, and a secondary gas permeable membrane provided between the spacer section and the primary gas permeable membrane, characterized in that the secondary gas permeable membrane has electrically insulating properties. a gas sensor, for establishment of a gas concentration on an active surface of the gas sensor, held by a housing body below a primary gas permeable membrane; at least one connector element moulded into the housing body such that the respective ends thereof protrude from a bottom of the housing body and such that they reach a top of the housing body to enable connectivity to the gas sensor such that signals may be carried from the gas sensor to the connector element; a sensor envelope providing an enclosure for the housing body and having a first opening facing the top of the housing body to accommodate the primary gas permeable membrane, and a second opening facing the bottom of the housing body to accommodate the at least one connector element that protrudes from the bottom of the housing body; means for retaining the primary gas permeable membrane in place above the gas sensor; a spacer section providing a separation distance between the gas sensor and the primary gas permeable membrane, and a secondary gas permeable membrane provided between the spacer section and the primary gas permeable membrane, characterized in that the secondary gas permeable membrane has electrically insulating properties.
A form-fill-seal machine, comprising: a conveyor for conveying a cylindrical film; a sealing unit for applying pressure and ultrasonic oscillation to the film conveyed by the conveyor to create a seal between overlapping portions of the film; and a controller configured to control at least one of: the pressure applied by the sealing unit to the film, and an amplitude of the ultrasonic oscillation applied to the film by the sealing unit, characterized in that the controller is further configured to control a speed of the film conveyed by the conveyor, the controller being configured to cause the sealing unit to apply at least one of the pressure and the ultrasonic oscillation to the film in a time period immediately prior to a first point in time at which the conveyor begins to convey the film, the controller being further configured to change, depending on the speed of the film, at least one of the pressure and the amplitude of the ultrasonic oscillation applied to the film in a time period after the first point in time. a conveyor for conveying a cylindrical film; a sealing unit for applying pressure and ultrasonic oscillation to the film conveyed by the conveyor to create a seal between overlapping portions of the film; and a controller configured to control at least one of: the pressure applied by the sealing unit to the film, and an amplitude of the ultrasonic oscillation applied to the film by the sealing unit, characterized in that the controller is further configured to control a speed of the film conveyed by the conveyor, the controller being configured to cause the sealing unit to apply at least one of the pressure and the ultrasonic oscillation to the film in a time period immediately prior to a first point in time at which the conveyor begins to convey the film, the controller being further configured to change, depending on the speed of the film, at least one of the pressure and the amplitude of the ultrasonic oscillation applied to the film in a time period after the first point in time.
A method for providing residential routing functionality, comprising the steps of forwarding upstream and downstream traffic; characterized in that - virtual local area networks are provided; - wherein operating a virtual local area network includes the steps of: - associating a residential router instance exclusively with a respective virtual local area network identifier; - populating a fixed match forwarding table with host entries learned during at least one of authentication of a residential router instance and IP address assignment for the residential router instance; - forwarding upstream traffic dependent upon said virtual local area network identifier designated by said upstream traffic being determined, wherein the virtual local area network identifier is dedicated to said instance of the residential router; and - forwarding downstream traffic dependent upon the host entry designated by said downstream traffic being determined, wherein the host entry is provided in said fixed match forwarding table. - virtual local area networks are provided; - wherein operating a virtual local area network includes the steps of: - associating a residential router instance exclusively with a respective virtual local area network identifier; - populating a fixed match forwarding table with host entries learned during at least one of authentication of a residential router instance and IP address assignment for the residential router instance; - forwarding upstream traffic dependent upon said virtual local area network identifier designated by said upstream traffic being determined, wherein the virtual local area network identifier is dedicated to said instance of the residential router; and - forwarding downstream traffic dependent upon the host entry designated by said downstream traffic being determined, wherein the host entry is provided in said fixed match forwarding table. - associating a residential router instance exclusively with a respective virtual local area network identifier; - populating a fixed match forwarding table with host entries learned during at least one of authentication of a residential router instance and IP address assignment for the residential router instance; - forwarding upstream traffic dependent upon said virtual local area network identifier designated by said upstream traffic being determined, wherein the virtual local area network identifier is dedicated to said instance of the residential router; and - forwarding downstream traffic dependent upon the host entry designated by said downstream traffic being determined, wherein the host entry is provided in said fixed match forwarding table.
A method for a control device configured to control, using a radio interface for radio reception and transmission, a media playback system comprising one or more zones, each zone comprising one or more playback devices, the method comprising: initiating, by the control device using said radio interface, media playback in a first zone comprising at least a first playback device; determining that the control device has moved from the first zone to a second zone by: receiving a radio transmission using said radio interface indicating a second playback device of a media playback system; based on the received radio transmission, determining that the control device is within a given proximity to a second zone of the media playback system that comprises the second playback device; and wherein the method further comprises, based on the determination using the received radio transmission, initiating, by the control device, the first and second zones to play back the media in synchrony. initiating, by the control device using said radio interface, media playback in a first zone comprising at least a first playback device; determining that the control device has moved from the first zone to a second zone by: receiving a radio transmission using said radio interface indicating a second playback device of a media playback system; based on the received radio transmission, determining that the control device is within a given proximity to a second zone of the media playback system that comprises the second playback device; and wherein the method further comprises, based on the determination using the received radio transmission, initiating, by the control device, the first and second zones to play back the media in synchrony. receiving a radio transmission using said radio interface indicating a second playback device of a media playback system; based on the received radio transmission, determining that the control device is within a given proximity to a second zone of the media playback system that comprises the second playback device; and wherein the method further comprises, based on the determination using the received radio transmission, initiating, by the control device, the first and second zones to play back the media in synchrony.