A compound of formula: or a stereoisomer, mixture of stereoisomers, and/or a pharmaceutically acceptable salt thereof, wherein: subscript n is an integer from 0 to 2; bond "a" is a single or double bond; R 1 is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl, heterocycloalkyl, heterocycloalkyl-C 1 -C 6 alkyl, R 5 -C -C 1 -C 6 alkyl, or -OR 4, wherein each of the C 3 -C 8 cycloalkyl and heterocycloalkyl groups is unsubstituted or substituted with one to six R 6; R 2 is halo, C 1 -C 6 alkyl, -S-C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 2a is halo or C 1 -C 6 alkyl; each R 3 is independently halo or C 1 -C 6 alkyl; R 3a and R 3b are each independently hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 4 is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl, heterocycloalkyl, heterocycloalkyl-C 1 -C 6 alkyl, or R 5 -C -C 1 -C 6 alkyl, wherein each of the C 3 -C 8 cycloalkyl and heterocycloalkyl groups is unsubstituted or substituted with one to six R 6; R 5 is hydroxy, C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamino, di-(C 1 -C 6 alkyl)amino, hydroxyamino, or N-C 1 -C 6 alkyl hydroxyamino; and each R 6 is independently halo, hydroxy, oxo, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 -hydroxyalkyl, C 1 -C 6 haloalkyl, amino, C 1 -C 6 alkylamino, di-(C 1 -C 6 alkyl)amino, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, or di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl. subscript n is an integer from 0 to 2; bond "a" is a single or double bond; R 1 is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl, heterocycloalkyl, heterocycloalkyl-C 1 -C 6 alkyl, R 5 -C -C 1 -C 6 alkyl, or -OR 4, wherein each of the C 3 -C 8 cycloalkyl and heterocycloalkyl groups is unsubstituted or substituted with one to six R 6; R 2 is halo, C 1 -C 6 alkyl, -S-C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 2a is halo or C 1 -C 6 alkyl; each R 3 is independently halo or C 1 -C 6 alkyl; R 3a and R 3b are each independently hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 4 is hydrogen, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl, heterocycloalkyl, heterocycloalkyl-C 1 -C 6 alkyl, or R 5 -C -C 1 -C 6 alkyl, wherein each of the C 3 -C 8 cycloalkyl and heterocycloalkyl groups is unsubstituted or substituted with one to six R 6; R 5 is hydroxy, C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamino, di-(C 1 -C 6 alkyl)amino, hydroxyamino, or N-C 1 -C 6 alkyl hydroxyamino; and each R 6 is independently halo, hydroxy, oxo, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 -hydroxyalkyl, C 1 -C 6 haloalkyl, amino, C 1 -C 6 alkylamino, di-(C 1 -C 6 alkyl)amino, amino-C 1 -C 6 alkyl, C 1 -C 6 alkylamino-C 1 -C 6 alkyl, or di-(C 1 -C 6 alkyl)amino-C 1 -C 6 alkyl.