A substituted pyrido[3,4-d]pyrimidin-4-one derivative compound selected from the group consisting of: 2-(4-((4-isopropylphenyl)(1-methylpiperidin-4-yl)amino)phenoxy)pyrido [3,4 d] pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(propyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(isopropyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(isobutyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(1-methylpiperidin-3-yl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-(cyclopentyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(pyrrolidin-3-yl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(1-methylpyrrolidin-3-yl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-(5-methylindolin-1-yl)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(5-methyl-1H-indol-1-yl)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(piperidin-3-yl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((3-(4-isopropylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(4-methylpiperazin-1-yl)phenyl)amino)-3-(trifluoromethyl)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(3-methyl-4-(methyl(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-((4-ethyl-3-methoxyphenyl)(methyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(methyl(3-(4-methylpiperazin-1-yl)-4-(2,2,2trifluoroethoxy)phenyl)amino)phenoxy) pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-ethyl-2-methoxyphenyl)(methyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((3-(4-ethylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(1-methylpiperidin-4-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(ethyl(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((cyclopropylmethyl)(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(methyl)amino)-3-(trifluoromethyl)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((4-ethylphenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((2-methoxy-5-(4-methylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((2-ethoxy-5-(4-methylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(2-methyl-5-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-((4-(tert-butyl)phenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; and 2-(3-methyl-4-(methyl(4-propylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol. 2-(4-((4-isopropylphenyl)(1-methylpiperidin-4-yl)amino)phenoxy)pyrido [3,4 d] pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(propyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(isopropyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(isobutyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(1-methylpiperidin-3-yl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-(cyclopentyl(4-isopropylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(pyrrolidin-3-yl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(1-methylpyrrolidin-3-yl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-(5-methylindolin-1-yl)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(5-methyl-1H-indol-1-yl)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(piperidin-3-yl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((3-(4-isopropylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(4-methylpiperazin-1-yl)phenyl)amino)-3-(trifluoromethyl)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(3-methyl-4-(methyl(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-((4-ethyl-3-methoxyphenyl)(methyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-(methyl(3-(4-methylpiperazin-1-yl)-4-(2,2,2trifluoroethoxy)phenyl)amino)phenoxy) pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((4-ethyl-2-methoxyphenyl)(methyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((3-(4-ethylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(3-(1-methylpiperidin-4-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(ethyl(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((cyclopropylmethyl)(3-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((4-isopropylphenyl)(methyl)amino)-3-(trifluoromethyl)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((4-ethylphenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; 2-(4-((2-methoxy-5-(4-methylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-((2-ethoxy-5-(4-methylpiperazin-1-yl)phenyl)(methyl)amino)phenoxy)pyrido[3,4-d] pyrimidin-4-ol; 2-(4-(methyl(2-methyl-5-(4-methylpiperazin-1-yl)phenyl)amino)phenoxy)pyrido[3,4 d] pyrimidin-4-ol; 2-(4-((4-(tert-butyl)phenyl)(methyl)amino)-3-methylphenoxy)pyrido[3,4-d]pyrimidin-4-ol; and 2-(3-methyl-4-(methyl(4-propylphenyl)amino)phenoxy)pyrido[3,4-d]pyrimidin-4-ol.