A tablet packaging device, comprising: a tablet accommodating portion configured to store a plurality of kinds of tablets and dispense a tablet based on prescription information; and a packaging portion configured to dispense the tablets, which are dispensed from the tablet accommodating portion, through a dispensing port and distribute and accommodate the tablets to a tray having a plurality of accommodation recess portions, characterised in that the packaging portion includes: a tray loading unit to which the tray is mountable; a tray unloading unit, which is arranged adjacent to the tray loading unit, and to which the tray accommodating the tablets is mountable; a tray driving unit, which is configured to removably support the tray, move the supported tray between positions of the tray loading unit and the tray unloading unit, and move the desired accommodation recess portion of the tray to the dispensing port for tablets; a tray attaching unit configured to attach the tray from the tray loading unit to the tray driving unit; and a tray detaching unit configured to detach the tray accommodating the tablets from the tray driving unit and place the tray on the tray unloading unit. a tablet accommodating portion configured to store a plurality of kinds of tablets and dispense a tablet based on prescription information; and a packaging portion configured to dispense the tablets, which are dispensed from the tablet accommodating portion, through a dispensing port and distribute and accommodate the tablets to a tray having a plurality of accommodation recess portions, characterised in that the packaging portion includes: a tray loading unit to which the tray is mountable; a tray unloading unit, which is arranged adjacent to the tray loading unit, and to which the tray accommodating the tablets is mountable; a tray driving unit, which is configured to removably support the tray, move the supported tray between positions of the tray loading unit and the tray unloading unit, and move the desired accommodation recess portion of the tray to the dispensing port for tablets; a tray attaching unit configured to attach the tray from the tray loading unit to the tray driving unit; and a tray detaching unit configured to detach the tray accommodating the tablets from the tray driving unit and place the tray on the tray unloading unit. characterised in that the packaging portion includes: a tray loading unit to which the tray is mountable; a tray unloading unit, which is arranged adjacent to the tray loading unit, and to which the tray accommodating the tablets is mountable; a tray driving unit, which is configured to removably support the tray, move the supported tray between positions of the tray loading unit and the tray unloading unit, and move the desired accommodation recess portion of the tray to the dispensing port for tablets; a tray attaching unit configured to attach the tray from the tray loading unit to the tray driving unit; and a tray detaching unit configured to detach the tray accommodating the tablets from the tray driving unit and place the tray on the tray unloading unit. a tray loading unit to which the tray is mountable; a tray unloading unit, which is arranged adjacent to the tray loading unit, and to which the tray accommodating the tablets is mountable; a tray driving unit, which is configured to removably support the tray, move the supported tray between positions of the tray loading unit and the tray unloading unit, and move the desired accommodation recess portion of the tray to the dispensing port for tablets; a tray attaching unit configured to attach the tray from the tray loading unit to the tray driving unit; and a tray detaching unit configured to detach the tray accommodating the tablets from the tray driving unit and place the tray on the tray unloading unit.