mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing an antibody suitable for use in an equine comprising the steps of: - providing a donor antibody from a species other than an equine, wherein the donor antibody has binding specificity for a target antigen present in equines; - comparing each amino acid residue of the amino acid sequence of framework regions of the donor antibody with each amino acid residue present at a corresponding position in the amino acid sequence of framework regions of a plurality of equine antibodies to identify one or more amino acid residues within the amino acid sequence of the framework regions of the donor antibody that differ from one or more amino acid residues at the corresponding position within the amino acid sequence of framework regions of the plurality of equine antibodies; and - substituting the one or more identified amino acid residues in the donor antibody with the one or more amino acid residues present at the corresponding position in the plurality of equine antibodies to produce a modified antibody, wherein the modified antibody does not contain any amino acid in any position within the framework regions which would be foreign at the corresponding position in equines, wherein the modified antibody is capable of specifically binding to equine nerve growth factor and inhibiting the ability of equine NGF to bind to the p75 or TrkA equine NGF receptor; and wherein substitution of an amino acid residue in the donor antibody is undertaken using the principle of conservative substitution. - providing a donor antibody from a species other than an equine, wherein the donor antibody has binding specificity for a target antigen present in equines; - comparing each amino acid residue of the amino acid sequence of framework regions of the donor antibody with each amino acid residue present at a corresponding position in the amino acid sequence of framework regions of a plurality of equine antibodies to identify one or more amino acid residues within the amino acid sequence of the framework regions of the donor antibody that differ from one or more amino acid residues at the corresponding position within the amino acid sequence of framework regions of the plurality of equine antibodies; and - substituting the one or more identified amino acid residues in the donor antibody with the one or more amino acid residues present at the corresponding position in the plurality of equine antibodies to produce a modified antibody,
Electronic unit for controlling one or more fire sensors of a fire detection system, comprising: - a processing stage; - a managing stage which can be connected, during a first interval of time (tl), to a data communication line configured to connect said one or more sensors to one another, said managing stage being activated by the processing stage to generate, during said first interval of time, first digital querying signals to be sent to said one or more sensors through the data communication line to check the operating status of the sensors, said managing stage comprising a switching circuit controlled by the processing stage during said first interval of time in which the receiver circuitry block is connected to the data communication line by the switching circuit, to receive and measure, during said first interval of time, second digital signals sent by said one or more sensors in reply to said first digital querying signals and to detect transmission faults through the data communication line, characterized in that said managing stage further comprises an operating status checking circuitry block of the receiver circuitry block directly connected to an output of the receiver circuitry block, said operating status checking circuitry block being activated by the processing stage to check the operating status of the receiver circuitry block during a second interval of time in which the receiver circuitry block is disconnected from the data communication line by the switching circuit. - a processing stage; - a managing stage which can be connected, during a first interval of time (tl), to a data communication line configured to connect said one or more sensors to one another, said managing stage being activated by the processing stage to generate, during said first interval of time, first digital querying signals to be sent to said one or more sensors through the data communication line to check the operating status of the sensors,
A mining machine to extract material from a deposit, the machine comprising: a main frame; a cutting boom pivotally mounted towards a first end at the main frame; a cutting head rotatably mounted at a second end of the cutting boom, the boom capable of raising and lowering the cutting head relative to the main frame; a cutting head motor to drive rotation of the cutting head and a gear assembly drivably connected between the motor and the cutting head to transmit power from the motor to the head; said cutting head motor being a single motor to drive rotation of the head, the single motor mounted at a first side of the boom at the second end immediately rearward of the cutting head; and the gear assembly being mounted at a second side of the boom at the second end immediately rearward of the cutting head, at least one drive shaft drivably coupled between the motor and the gear assembly; characterised by: at least a pair of bearing carriers extending respectively between the first and second sides of the boom and the cutting head to mount the cutting head at the boom. a main frame; a cutting boom pivotally mounted towards a first end at the main frame; a cutting head rotatably mounted at a second end of the cutting boom, the boom capable of raising and lowering the cutting head relative to the main frame; a cutting head motor to drive rotation of the cutting head and a gear assembly drivably connected between the motor and the cutting head to transmit power from the motor to the head; said cutting head motor being a single motor to drive rotation of the head, the single motor mounted at a first side of the boom at the second end immediately rearward of the cutting head; and the gear assembly being mounted at a second side of the boom at the second end immediately rearward of the cutting head, at least one drive shaft drivably coupled between the motor and the gear assembly; characterised by: at least a pair of bearing carriers extending respectively between the first and second sides of the boom and the cutting head to mount the cutting head at the boom. at least a pair of bearing carriers extending respectively between the first and second sides of the boom and the cutting head to mount the cutting head at the boom.
A compound or a pharmaceutically acceptable salt thereof, characterized in that said compound is selected from the group consisting of: CPT1: 9-t-butyloxyethyloxime-10-[(4'-piperidinylpiperidinyl)carbonyloxy]-camptothecin; CPT2: 9-t-butyloxyethyloxime-10-hydroxy-camptothecin; CPT3: 9-t-butyloxyethyloxime-10-fluoro-camptothecin; CPT7: 9-t-butyloxyethyloxime-camptothecin; and CPT8: 9-t-butyloxyethyloxime-10-acetoxy]-camptothecin. CPT1: 9-t-butyloxyethyloxime-10-[(4'-piperidinylpiperidinyl)carbonyloxy]-camptothecin; CPT2: 9-t-butyloxyethyloxime-10-hydroxy-camptothecin; CPT3: 9-t-butyloxyethyloxime-10-fluoro-camptothecin; CPT7: 9-t-butyloxyethyloxime-camptothecin; and CPT8: 9-t-butyloxyethyloxime-10-acetoxy]-camptothecin.
An apparatus for X-ray image inhalation quality monitoring, comprising: - a processing unit; wherein the processing unit is configured to receive an X-ray image of a region of interest of a patient, to generate a diaphragm line representing a path of a diaphragm in the X-ray image, to generate a rib line representing a path of rib bones in the X-ray image, to detect the diaphragm line, and to detect the rib line, to assess the X-ray image for the presence of an intersection condition between (i) the diaphragm line and (ii) the rib line, wherein the intersection condition of the diaphragm line and the rib line is defined according to an intersection condition rule, and wherein the processor is configured to compare the presence of the intersection condition between the rib line and the diaphragm line with a pre-determined X-ray image inhalation quality monitoring rule specifying an image inhalation state in terms of the intersection condition, and to yield an X-ray image inhalation quality measure. - a processing unit;
A vehicle including a head-up display device and a vehicle air conditioning duct structure, said air conditioning duct structure comprising: a front defroster nozzle which is provided in a vehicle front part, extends in a vehicle width direction, and is formed such that one end portion is connected to an air conditioning device disposed on a rear surface side of an instrument panel and the other end portion is disposed inside a front pillar and is provided with a front side air outlet opening toward a windshield glass; and a side defroster nozzle of which a tip portion is provided with a side air outlet opening toward a front side glass; characterized in that: the side defroster nozzle is branched from an upstream side of the front side air outlet of the front defroster nozzle; in top view, the front defroster nozzle includes a width direction extension portion which is a portion being on a vehicle rear side of the head-up display device and extending in the vehicle width direction along the head-up display device and a front and rear direction extension portion which is a portion being on the outside of the head-up display device in the vehicle width direction and extending from an outer end portion of the width direction extension portion in the vehicle width direction in a vehicle front and rear direction. a front defroster nozzle which is provided in a vehicle front part, extends in a vehicle width direction, and is formed such that one end portion is connected to an air conditioning device disposed on a rear surface side of an instrument panel and the other end portion is disposed inside a front pillar and is provided with a front side air outlet opening toward a windshield glass; and a side defroster nozzle of which a tip portion is provided with a side air outlet opening toward a front side glass; characterized in that: the side defroster nozzle is branched from an upstream side of the front side air outlet of the front defroster nozzle; in top view, the front defroster nozzle includes a width direction extension portion which is a portion being on a vehicle rear side of the head-up display device and extending in the vehicle width direction along the head-up display device and a front and rear direction extension portion which is a portion being on the outside of the head-up display device in the vehicle width direction and extending from an outer end portion of the width direction extension portion in the vehicle width direction in a vehicle front and rear direction.
A toaster device with heating elements, comprising; a main housing and a reciprocating toast carriage; the toast carriage having a lower position that corresponds with the heating elements being energised and an elevated position; an electric motor that is operable to lower the carriage to the lower position; a user activated control that communicates with a control means for controlling the electric motor and that has a regular toasting cycle input means adapted to provide toasting for a user-selected regular toasting cycle; the toaster device being characterised by: the user activated electronic control also having a separate toasting cycle extension input means, which can be operatively selected by a user after the regular toasting cycle ends, and which is adapted to provide additional toasting for a predefined extension period; and wherein user selection of the toasting cycle extension input means starts a toasting cycle extension that causes: lowering of the carriage into the lower position; energising of the heating element for a predefined extension period; and raising of the carriage to the upper position. the user activated electronic control also having a separate toasting cycle extension input means, which can be operatively selected by a user after the regular toasting cycle ends, and which is adapted to provide additional toasting for a predefined extension period; and wherein user selection of the toasting cycle extension input means starts a toasting cycle extension that causes: lowering of the carriage into the lower position; energising of the heating element for a predefined extension period; and raising of the carriage to the upper position.
A method of operation of a base station for supporting carrier aggregation between different radio access networks, the base station configured for operation in a cellular radio access network, the method comprising: - configuring an access point of a Wireless Local Area Network, WLAN, with a Pairwise Temporal Key, PTK, originating from a key K eNB; and - sending a random number to a wireless device associated with a given identifier to generate the PTK originating from the K eNB and the random number, in order to provide encryption of data; and - configuring said access point to forward data from the wireless device to said base station, wherein the data is encrypted using at least the PTK. - configuring an access point of a Wireless Local Area Network, WLAN, with a Pairwise Temporal Key, PTK, originating from a key K eNB; and - sending a random number to a wireless device associated with a given identifier to generate the PTK originating from the K eNB and the random number, in order to provide encryption of data; and - configuring said access point to forward data from the wireless device to said base station, wherein the data is encrypted using at least the PTK.
A straddled vehicle comprising: a vehicle body frame including a head pipe and a down frame extending downward from the head pipe with regard to an up-and-down direction of the vehicle; a leg shield disposed behind the head pipe and the down frame with regard to a front-and-rear direction of the vehicle; and a loading hook disposed on the leg shield, wherein the leg shield includes an upper panel, and a lower panel disposed below the upper panel with regard to the up-and-down direction of the vehicle, the lower panel is separated from the upper panel, the lower panel includes a bottom panel portion, and an extending portion integrated with the bottom panel portion, the extending portion is extending from the bottom panel portion to an upper side than a lower end of the upper panel with regard to the up-and-down direction of the vehicle, and the loading hook is fixed to the vehicle body frame through the extending portion, characterized in that the upper panel includes a pocket portion, the pocket portion including a first opening, the first opening disposed lateral to the extending portion with regard to a right-and-left direction of the vehicle, the straddled vehicle further comprises an inner case disposed inside the upper panel, the inner case is disposed in the pocket portion, and the inner case is connected to the lower panel. a vehicle body frame including a head pipe and a down frame extending downward from the head pipe with regard to an up-and-down direction of the vehicle; a leg shield disposed behind the head pipe and the down frame with regard to a front-and-rear direction of the vehicle; and a loading hook disposed on the leg shield, wherein the leg shield includes an upper panel, and a lower panel disposed below the upper panel with regard to the up-and-down direction of the vehicle, the lower panel is separated from the upper panel, the lower panel includes a bottom panel portion, and an extending portion integrated with the bottom panel portion, the extending portion is extending from the bottom panel portion to an upper side than a lower end of the upper panel with regard to the up-and-down direction of the vehicle, and the loading hook is fixed to the vehicle body frame through the extending portion, characterized in that the upper panel includes a pocket portion, the pocket portion including a first opening, the first opening disposed lateral to the extending portion with regard to a right-and-left direction of the vehicle, the straddled vehicle further comprises an inner case disposed inside the upper panel, the inner case is disposed in the pocket portion, and the inner case is connected to the lower panel.
A method of pairing users for uplink multi-user multiple-input-multiple-output (MU-MIMO) under coordinated multipoint transmission (CoMP) scenario in a communication system, comprising: A) selecting, by a first cell of the communication system, at least one initial user served by the cell as a first paired user; B) selecting, by the first cell, a candidate paired user according to the service type of the first paired user; and C) determining, from the different service types of the first paired user and the candidate paired user, a pairing type to be formed, and determining whether the candidate paired user and the first paired user can be paired into the pairing type to be formed by using a predetermined determination criterion according to the pairing type; wherein during the process of selecting the candidate paired user in the step B, if the first paired user is a CoMP user, then another CoMP user is selected as its candidate paired user, and if the first paired user is a single-cell service user, then all other users involved in the first cell are selected as its candidate paired users. A) selecting, by a first cell of the communication system, at least one initial user served by the cell as a first paired user; B) selecting, by the first cell, a candidate paired user according to the service type of the first paired user; and C) determining, from the different service types of the first paired user and the candidate paired user, a pairing type to be formed, and determining whether the candidate paired user and the first paired user can be paired into the pairing type to be formed by using a predetermined determination criterion according to the pairing type;
A method of controlling a well in a geological structure, the well comprising: a first casing string and a second casing string, the second casing string at least partially inside the first casing string; the first casing string and the second casing string defining a first inter-casing annulus therebetween, the second casing string defining a second casing bore therewithin; and a primary fluid flow control device in the second casing string to provide fluid communication between the first inter-casing annulus and the second casing bore; the method comprising the steps of: drilling a borehole through at least a portion of the geological structure to reach the well, thus creating a relief well; creating a fluid communication path through the first casing string to provide fluid communication between the relief well and the first inter-casing annulus of the well; introducing a fluid into the relief well and then into the first inter-casing annulus; and opening the primary fluid flow control device and directing the fluid between the first inter-casing annulus and the second casing bore. a first casing string and a second casing string, the second casing string at least partially inside the first casing string; the first casing string and the second casing string defining a first inter-casing annulus therebetween, the second casing string defining a second casing bore therewithin; and a primary fluid flow control device in the second casing string to provide fluid communication between the first inter-casing annulus and the second casing bore; the method comprising the steps of: drilling a borehole through at least a portion of the geological structure to reach the well, thus creating a relief well; creating a fluid communication path through the first casing string to provide fluid communication between the relief well and the first inter-casing annulus of the well; introducing a fluid into the relief well and then into the first inter-casing annulus; and opening the primary fluid flow control device and directing the fluid between the first inter-casing annulus and the second casing bore.
Segment roller, which has at least one roller body that is mounted rotatably about at least one axis, wherein the at least one roller body has on the outside at least one groove, in which at least one tongue of at least one profile displaceable along the length of the at least one axis engages, which profile clasps at least one material web directly or indirectly, the at least one profile is of shear-resistant configuration, characterized in that on the at least one roller body and/or on the at least one profile is provided at least one elastic lip, which, upon the engagement of the at least one tongue in the at least one groove, is elastically deformable in order to hold the at least one profile with little vibration in a displaceable manner.
An integrated circuit for sensing ions comprising: a substrate carrying plurality of circuit elements; a metallization stack over said substrate for providing interconnections to at least some of said circuit elements, the metallization stack comprising a plurality of patterned metal layers spatially separated from each other by respective electrically insulating layers, at least some of said electrically insulating layers comprising conductive portions that electrically interconnect portions of adjacent metal layers, wherein a first patterned metal layer comprises a plurality of ionsensitive electrodes, each ion-sensitive electrode being electrically connected to at least one of said circuit elements; a plurality of sample volumes extending into said metallization stack, each sample volume terminating at one of said ion-sensitive electrodes; and an ion-sensitive layer lining at least the ion-sensitive electrodes in said sample volumes; wherein the metallization stack further comprises a second patterned metal layer over the first patterned metal layer, said second patterned metal layer comprising a plurality of apertures, each sample volume extending towards one of said ion-sensitive electrodes from one of said apertures. a substrate carrying plurality of circuit elements; a metallization stack over said substrate for providing interconnections to at least some of said circuit elements, the metallization stack comprising a plurality of patterned metal layers spatially separated from each other by respective electrically insulating layers, at least some of said electrically insulating layers comprising conductive portions that electrically interconnect portions of adjacent metal layers, wherein a first patterned metal layer comprises a plurality of ionsensitive electrodes, each ion-sensitive electrode being electrically connected to at least one of said circuit elements; a plurality of sample volumes extending into said metallization stack, each sample volume terminating at one of said ion-sensitive electrodes; and an ion-sensitive layer lining at least the ion-sensitive electrodes in said sample volumes; wherein the metallization stack further comprises a second patterned metal layer over the first patterned metal layer, said second patterned metal layer comprising a plurality of apertures, each sample volume extending towards one of said ion-sensitive electrodes from one of said apertures.