A compound having the structure: or a pharmaceutically acceptable salt or tautomer thereof, wherein: A is a bond or C 1-3 alkylene; R 1 is selected from C 6 -C 10 aryl, 5- or 6-membered monocyclic heteroaryl or 9- to 11-membered bicyclic heteroaryl, wherein said C 6 -C 10 aryl group, said 5 or 6-membered monocyclic heteroaryl group or said 9- to 11-membered bicyclic heteroaryl group can be optionally substituted with one or more groups, each independently selected from halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, -CN, -N(R 4) 2, -OH, -O-(C 1 -C 6 alkyl), -O-(C 1 -C 6 haloalkyl), -OC R 7, - C N(R 4) 2; - NHC R 7 and -C OR 7 R 2 and R 3, together with the carbon atoms to which they are attached join to form a cyclic group Y; each occurrence of R 4 is independently selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, -(C 1-3 alkylene)-O-(C 1 -C 6 alkyl), or -C -R 10; R 7 is H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl; R 8 is H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl, or R 7 and R 8 and the common carbon atom to which they are attached, combine to form a carbonyl group; R 10 is C 1 -C 6 alkyl, C 6 -C 10 aryl, C 3 -C 7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 9- to 11-membered bicyclic heteroaryl, 4- to 8-membered monocyclic heterocycloalkyl, or 8- to 11-membered bicyclic heterocycloalkyl; Y is: or wherein the * symbols designate the point of attachment of R 2 and R 3 to the rest of the compound; R 6 is selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 6 -C 10 aryl, 5- or 6-membered monocyclic heterocycloaryl and 9 to 11-membered bicyclic heterocycloaryl; and each occurrence of R 9 is selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl and - (C 1-3 alkylene)-O-(C 1 -C 6 alkyl). A is a bond or C 1-3 alkylene; R 1 is selected from C 6 -C 10 aryl, 5- or 6-membered monocyclic heteroaryl or 9- to 11-membered bicyclic heteroaryl, wherein said C 6 -C 10 aryl group, said 5 or 6-membered monocyclic heteroaryl group or said 9- to 11-membered bicyclic heteroaryl group can be optionally substituted with one or more groups, each independently selected from halo, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, -CN, -N(R 4) 2, -OH, -O-(C 1 -C 6 alkyl), -O-(C 1 -C 6 haloalkyl), -OC R 7, - C N(R 4) 2; - NHC R 7 and -C OR 7 R 2 and R 3, together with the carbon atoms to which they are attached join to form a cyclic group Y; each occurrence of R 4 is independently selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, -(C 1-3 alkylene)-O-(C 1 -C 6 alkyl), or -C -R 10; R 7 is H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl; R 8 is H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl or phenyl, or R 7 and R 8 and the common carbon atom to which they are attached, combine to form a carbonyl group; R 10 is C 1 -C 6 alkyl, C 6 -C 10 aryl, C 3 -C 7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 9- to 11-membered bicyclic heteroaryl, 4- to 8-membered monocyclic heterocycloalkyl, or 8- to 11-membered bicyclic heterocycloalkyl; Y is: or wherein the * symbols designate the point of attachment of R 2 and R 3 to the rest of the compound; R 6 is selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 6 -C 10 aryl, 5- or 6-membered monocyclic heterocycloaryl and 9 to 11-membered bicyclic heterocycloaryl; and each occurrence of R 9 is selected from H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl and - (C 1-3 alkylene)-O-(C 1 -C 6 alkyl).