An end effector of a tissue treatment device comprising: a uterine manipulator including an elongate shaft having a distal end portion, wherein the distal end portion is configured to be inserted into a lumen of a cervix; and a colpotomy cup coupled to the uterine manipulator, the colpotomy cup comprising: a cut guide having an outer wall portion and a base portion supporting the outer wall portion, the outer wall portion configured to surround at least a portion of the cervix, the outer wall portion extending from a first proximal end portion to a first distal end portion along a longitudinal path; an integral cutting device having an active electrode and configured to be actuated to rotate about the distal end of the cut guide; and characterized in that the colpotomy cup further comprises: a protrusion extending distally away from the base portion, the protrusion laterally spaced away from the outer wall portion and extending along the longitudinal path, wherein: the protrusion is configured to be inserted into a lumen of the cervix the protrusion includes a return electrode member that is configured to be electrically connected to an electrosurgical generator; and the uterine manipulator passes through the protrusion. a uterine manipulator including an elongate shaft having a distal end portion, wherein the distal end portion is configured to be inserted into a lumen of a cervix; and a colpotomy cup coupled to the uterine manipulator, the colpotomy cup comprising: a cut guide having an outer wall portion and a base portion supporting the outer wall portion, the outer wall portion configured to surround at least a portion of the cervix, the outer wall portion extending from a first proximal end portion to a first distal end portion along a longitudinal path; an integral cutting device having an active electrode and configured to be actuated to rotate about the distal end of the cut guide; and characterized in that the colpotomy cup further comprises: a protrusion extending distally away from the base portion, the protrusion laterally spaced away from the outer wall portion and extending along the longitudinal path, wherein: the protrusion is configured to be inserted into a lumen of the cervix the protrusion includes a return electrode member that is configured to be electrically connected to an electrosurgical generator; and the uterine manipulator passes through the protrusion. a cut guide having an outer wall portion and a base portion supporting the outer wall portion, the outer wall portion configured to surround at least a portion of the cervix, the outer wall portion extending from a first proximal end portion to a first distal end portion along a longitudinal path; an integral cutting device having an active electrode and configured to be actuated to rotate about the distal end of the cut guide; and characterized in that the colpotomy cup further comprises: a protrusion extending distally away from the base portion, the protrusion laterally spaced away from the outer wall portion and extending along the longitudinal path, wherein: the protrusion is configured to be inserted into a lumen of the cervix the protrusion includes a return electrode member that is configured to be electrically connected to an electrosurgical generator; and the uterine manipulator passes through the protrusion. the protrusion is configured to be inserted into a lumen of the cervix the protrusion includes a return electrode member that is configured to be electrically connected to an electrosurgical generator; and the uterine manipulator passes through the protrusion.