A system, comprising: a signal generator configured for generating a pulse waveform, the pulse waveform including: a first level of a hierarchy of the pulse waveform includes a first set of pulses, each pulse having a pulse time duration, a first time interval separating successive pulses; a second level of the hierarchy of the pulse waveform includes a plurality of first sets of pulses as a second set of pulses, a second time interval separating successive first sets of pulses, the second time interval being at least three times the duration of the first time interval; and a third level of the hierarchy of the pulse waveform includes a plurality of second sets of pulses as a third set of pulses, a third time interval separating successive second sets of pulses, the third time interval being at least thirty times the duration of the second level time interval; and an ablation device (110; 600; 700) coupled to the signal generator and configured to receive the pulse waveform, the ablation device (110; 600; 700) including a set of spines (614; 714), the ablation device (110; 600; 700) configured for delivering the pulse waveform to tissue during use via one or more spines (614; 714) of the set of spines (614; 714), each spine (614; 714) including: a set of independently addressable electrodes (616; 716) formed on a surface of each of the one or more spines (614; 716), each electrode of the set of electrodes (616; 716) having an insulated electrical lead associated therewith, the insulated electrical leads disposed in a body of each of the one or more spines. a signal generator configured for generating a pulse waveform, the pulse waveform including: a first level of a hierarchy of the pulse waveform includes a first set of pulses, each pulse having a pulse time duration, a first time interval separating successive pulses; a second level of the hierarchy of the pulse waveform includes a plurality of first sets of pulses as a second set of pulses, a second time interval separating successive first sets of pulses, the second time interval being at least three times the duration of the first time interval; and a third level of the hierarchy of the pulse waveform includes a plurality of second sets of pulses as a third set of pulses, a third time interval separating successive second sets of pulses, the third time interval being at least thirty times the duration of the second level time interval; and a first level of a hierarchy of the pulse waveform includes a first set of pulses, each pulse having a pulse time duration, a first time interval separating successive pulses; a second level of the hierarchy of the pulse waveform includes a plurality of first sets of pulses as a second set of pulses, a second time interval separating successive first sets of pulses, the second time interval being at least three times the duration of the first time interval; and a third level of the hierarchy of the pulse waveform includes a plurality of second sets of pulses as a third set of pulses, a third time interval separating successive second sets of pulses, the third time interval being at least thirty times the duration of the second level time interval; and an ablation device (110; 600; 700) coupled to the signal generator and configured to receive the pulse waveform, the ablation device (110; 600; 700) including a set of spines (614; 714), the ablation device (110; 600; 700) configured for delivering the pulse waveform to tissue during use via one or more spines (614; 714) of the set of spines (614; 714), each spine (614; 714) including: a set of independently addressable electrodes (616; 716) formed on a surface of each of the one or more spines (614; 716), each electrode of the set of electrodes (616; 716) having an insulated electrical lead associated therewith, the insulated electrical leads disposed in a body of each of the one or more spines.