A method for managing the power supply in an electronic circuit comprising a processing system (11; 11'), in particular a general purpose microcontroller or a System-on-Chip or a subsystem thereof, with a radio-frequency embedded circuit, said processing system (11; 11') comprising at least a processing core (30, V12I, V12O) and a first power regulation module supplying a first regulated voltage to said processing core, said radio frequency embedded circuit comprising a second power regulation module supplying a second regulated voltage (V reg) to circuits of the radio-frequency embedded circuit including a radio frequency transceiving portion, said second power regulation module comprising a switched-mode power supply and generating a second regulated voltage (V reg), said method comprising coupling said second regulated voltage (V reg) as voltage input of said first power regulation module, said first power regulation module which generates as an output a respective first regulated voltage (V regm) for said processing core, controlling said second power regulation module to operate according to a plurality of operation modes (LP1, LP2, A1, A2, LP3, LP4) including one or more sleep modes (LP1, LP2) in which both the DC-DC converter and the second linear regulator are off and one or more active modes (A1, A2) in which both the DC-DC converter and the second linear regulator are on, wherein said second power regulation module comprises a second linear regulator and said plurality of modes (LP1, LP2, A1, A2, LP3, LP4) includes a first further sleep mode in which the switched-mode power supply is off and the second linear regulator is on and a second further sleep mode in which the switched-mode power supply is on and the second linear regulator is off, the first further sleep mode and second further sleep mode being controlled by the processing system. said processing system (11; 11') comprising at least a processing core (30, V12I, V12O) and a first power regulation module supplying a first regulated voltage to said processing core, said radio frequency embedded circuit comprising a second power regulation module supplying a second regulated voltage (V reg) to circuits of the radio-frequency embedded circuit including a radio frequency transceiving portion, said second power regulation module comprising a switched-mode power supply and generating a second regulated voltage (V reg), said method comprising coupling said second regulated voltage (V reg) as voltage input of said first power regulation module, said first power regulation module which generates as an output a respective first regulated voltage (V regm) for said processing core, controlling said second power regulation module to operate according to a plurality of operation modes (LP1, LP2, A1, A2, LP3, LP4) including one or more sleep modes (LP1, LP2) in which both the DC-DC converter and the second linear regulator are off and one or more active modes (A1, A2) in which both the DC-DC converter and the second linear regulator are on, wherein said second power regulation module comprises a second linear regulator and said plurality of modes (LP1, LP2, A1, A2, LP3, LP4) includes a first further sleep mode in which the switched-mode power supply is off and the second linear regulator is on and a second further sleep mode in which the switched-mode power supply is on and the second linear regulator is off, the first further sleep mode and second further sleep mode being controlled by the processing system.