A biopsy needle for collecting a tissue specimen comprising: a handle housing (310; 1310); an outer cannula (130; 1030) that is at least partially received within the handle housing (310; 1310); an inner tube (120; 1020) received within the outer cannula (130; 1030) and configured to receive a stylet (101; 1001), wherein the outer cannula (130; 1030) and inner tube (120; 1020) extend distally beyond a distal end of the handle housing (310; 1310); a snare coil (200; 1200) attached between the inner tube (120; 1020) and the outer cannula (130; 1030); a movable base (400; 1510) disposed within the handle housing (310; 1310), wherein the outer cannula (130; 1030) is fixedly coupled to a needle holder that is coupled to and carried by the movable base (400; 1510), the movable base (400; 1510) being axially movable within the handle housing (310; 1310); an inner driven structure (150; 1650) that is coupled to the inner tube (120; 1020) and is detachably coupled to the movable base (400; 1510) and is configured to move axially within the housing with the movable base (400; 1510) and further is configured to move axially across a surface of the movable base (400; 1510) when the movable base (400; 1510) is stationary, wherein the coupling between the inner driven structure (150; 1650) and the inner tube (120; 1020) is such that the axial driving of the inner driven structure (150; 1650) imparts rotation to the inner tube (120; 1020) relative to the outer cannula (130; 1030); a first biasing mechanism configured to apply a biasing force to the inner driven structure (150; 1650) for driving the inner driven structure (150; 1650) and the movable base (400; 1510) in a distal direction when the first biasing mechanism releases stored energy; wherein in a first stage of operation, the inner driven structure (150; 1650) is coupled to the movable base (400; 1510) and the first biasing mechanism releases the stored energy to drive the coupled inner driven structure (150; 1650) and movable base (400; 1510) in the distal direction and at an end of the first stage of operation, the inner driven structure (150; 1650) disengages from the movable base (400; 1510) and the inner driven structure (150; 1650) travels axially along the movable base (400; 1510) in the distal direction to cause rotation of the inner tube (120; 1020) relative to the outer cannula (130; 1030), thereby causing activation of the snare coil (200; 1200) as part of a second stage of operation. a handle housing (310; 1310); an outer cannula (130; 1030) that is at least partially received within the handle housing (310; 1310); an inner tube (120; 1020) received within the outer cannula (130; 1030) and configured to receive a stylet (101; 1001), wherein the outer cannula (130; 1030) and inner tube (120; 1020) extend distally beyond a distal end of the handle housing (310; 1310); a snare coil (200; 1200) attached between the inner tube (120; 1020) and the outer cannula (130; 1030); a movable base (400; 1510) disposed within the handle housing (310; 1310), wherein the outer cannula (130; 1030) is fixedly coupled to a needle holder that is coupled to and carried by the movable base (400; 1510), the movable base (400; 1510) being axially movable within the handle housing (310; 1310); an inner driven structure (150; 1650) that is coupled to the inner tube (120; 1020) and is detachably coupled to the movable base (400; 1510) and is configured to move axially within the housing with the movable base (400; 1510) and further is configured to move axially across a surface of the movable base (400; 1510) when the movable base (400; 1510) is stationary, wherein the coupling between the inner driven structure (150; 1650) and the inner tube (120; 1020) is such that the axial driving of the inner driven structure (150; 1650) imparts rotation to the inner tube (120; 1020) relative to the outer cannula (130; 1030); a first biasing mechanism configured to apply a biasing force to the inner driven structure (150; 1650) for driving the inner driven structure (150; 1650) and the movable base (400; 1510) in a distal direction when the first biasing mechanism releases stored energy; wherein in a first stage of operation, the inner driven structure (150; 1650) is coupled to the movable base (400; 1510) and the first biasing mechanism releases the stored energy to drive the coupled inner driven structure (150; 1650) and movable base (400; 1510) in the distal direction and at an end of the first stage of operation, the inner driven structure (150; 1650) disengages from the movable base (400; 1510) and the inner driven structure (150; 1650) travels axially along the movable base (400; 1510) in the distal direction to cause rotation of the inner tube (120; 1020) relative to the outer cannula (130; 1030), thereby causing activation of the snare coil (200; 1200) as part of a second stage of operation.