A biopsy device, comprising: a housing body defining a longitudinal axis; a cannula assembly having an actuator body and an elongate cannula affixed to the actuator body, the elongate cannula having a side wall defining a lumen, and having a vacuum side port that extends through the side wall and in fluid communication with the lumen; the actuator body having a drive tab and a proximal latch mechanism, the proximal latch mechanism configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; a cannula drive spring coupled between the housing body and the actuator body, the cannula drive spring configured to be compressed when the proximal latch mechanism is moved to the retracted position and configured to decompress to propel the elongate cannula in a distal direction when the proximal latch mechanism is released from the retracted position; a vacuum source coupled to the housing body and configured to store a vacuum, the vacuum source including a vacuum chamber housing having a chamber open end, a chamber end wall, a chamber side wall extending between the chamber open end and the chamber end wall, and a chamber vacuum port; and a trigger slide assembly having a slider body operatively coupled to the drive tab of the cannula assembly and to the vacuum source characterized in that the chamber side wall of the vacuum chamber housing has a perimeter defining a U-shaped area in cross-section that extends longitudinally between the chamber open end and the chamber end wall to define a U-shaped volume. a housing body defining a longitudinal axis; a cannula assembly having an actuator body and an elongate cannula affixed to the actuator body, the elongate cannula having a side wall defining a lumen, and having a vacuum side port that extends through the side wall and in fluid communication with the lumen; the actuator body having a drive tab and a proximal latch mechanism, the proximal latch mechanism configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; the elongate cannula having a side wall defining a lumen, and having a vacuum side port that extends through the side wall and in fluid communication with the lumen; the actuator body having a drive tab and a proximal latch mechanism, the proximal latch mechanism configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; a cannula drive spring coupled between the housing body and the actuator body, the cannula drive spring configured to be compressed when the proximal latch mechanism is moved to the retracted position and configured to decompress to propel the elongate cannula in a distal direction when the proximal latch mechanism is released from the retracted position; a vacuum source coupled to the housing body and configured to store a vacuum, the vacuum source including a vacuum chamber housing having a chamber open end, a chamber end wall, a chamber side wall extending between the chamber open end and the chamber end wall, and a chamber vacuum port; and a trigger slide assembly having a slider body operatively coupled to the drive tab of the cannula assembly and to the vacuum source characterized in that the chamber side wall of the vacuum chamber housing has a perimeter defining a U-shaped area in cross-section that extends longitudinally between the chamber open end and the chamber end wall to define a U-shaped volume.