A process for manufacturing an alkylene oxide by reacting a feed gas comprising an alkylene, oxygen, and an at least one organic chloride over a high efficiency silver catalyst to yield a reaction product comprising the alkylene oxide, wherein the feed gas has an overall catalyst chloriding effectiveness, and the reaction is carried out at a reaction temperature, the process comprising: selecting a decrease in at least one of the concentration of the alkylene oxide in the reaction product and the yield of the alkylene oxide; varying the overall catalyst chloriding effectiveness and the reaction temperature in an alternating sequence such that when one of the overall catalyst chloriding effectiveness and the reaction temperature is varied, the other of the overall catalyst chloriding effectiveness and the reaction temperature is maintained at a substantially constant value for a selected period of time, wherein the step of varying the overall catalyst chloriding effectiveness and the reaction temperature in an alternating sequence comprises varying one of the overall catalyst chloriding effectiveness and the reaction temperature in response to the selected decrease in at least one of the concentration of the alkylene oxide in the reaction product and the yield of the alkylene oxide; wherein the overall catalyst chloriding effectiveness value is represented by the formula: Z * = ethyl chloride equivalent ppmv ethane equivalent mole percent wherein the ethyl chloride equivalent is the total concentration in ppmv of ethyl chloride which provides substantially the same catalyst chloriding effectiveness of the at least one organic chloride in the feed gas at the concentration of the at least one organic chloride in the feed gas; and the ethane equivalent is the total concentration in mole percent of ethane which provides substantially the same dechloriding effectiveness as the non-chloride containing hydrocarbons in the feed gas at the concentration of the non-chloride containing hydrocarbons in the feed gas; and wherein the said high efficiency silver catalyst is a catalyst capable of producing an alkylene oxide from the corresponding alkylene and oxygen at an efficiency greater than 85.7 percent. selecting a decrease in at least one of the concentration of the alkylene oxide in the reaction product and the yield of the alkylene oxide; varying the overall catalyst chloriding effectiveness and the reaction temperature in an alternating sequence such that when one of the overall catalyst chloriding effectiveness and the reaction temperature is varied, the other of the overall catalyst chloriding effectiveness and the reaction temperature is maintained at a substantially constant value for a selected period of time, wherein the step of varying the overall catalyst chloriding effectiveness and the reaction temperature in an alternating sequence comprises varying one of the overall catalyst chloriding effectiveness and the reaction temperature in response to the selected decrease in at least one of the concentration of the alkylene oxide in the reaction product and the yield of the alkylene oxide; wherein the overall catalyst chloriding effectiveness value is represented by the formula: Z * = ethyl chloride equivalent ppmv ethane equivalent mole percent wherein the ethyl chloride equivalent is the total concentration in ppmv of ethyl chloride which provides substantially the same catalyst chloriding effectiveness of the at least one organic chloride in the feed gas at the concentration of the at least one organic chloride in the feed gas; and the ethane equivalent is the total concentration in mole percent of ethane which provides substantially the same dechloriding effectiveness as the non-chloride containing hydrocarbons in the feed gas at the concentration of the non-chloride containing hydrocarbons in the feed gas; and wherein the said high efficiency silver catalyst is a catalyst capable of producing an alkylene oxide from the corresponding alkylene and oxygen at an efficiency greater than 85.7 percent.