mhurhangee/ep-ind-claims huggingface dataset:
A process for the preparation of a single enantiomer of norepinephrine or of an addition salt thereof, the process comprising the following steps: a) reacting a compound of formula wherein X is halogen (F, Cl, Br, I), with benzylamine in a suitable solvent, using an auxiliary base, under the atmosphere of an inert gas, and isolating the resulting condensation product as an acid addition salt with a carboxylic acid, to give a compound of formula wherein R is hydrogen, or the residue of an aliphatic, cycloaliphatic or aromatic monocarboxylic or dicarboxylic acid; b) enantioselective reduction of the benzylamino ketone acid addition salt of Formula III to give a single enantiomer of the benzylamino alcohol of Formula V wherein the carbon atom bearing the waxy bond can be in the or configuration; c) debenzylation of the single enantiomer of the compound of Formula V to give a single enantiomer of norepinephrine, and d) isolating the single enantiomer of norepinephrine as a free base or acid addition salt thereof. a) reacting a compound of formula wherein X is halogen (F, Cl, Br, I), with benzylamine in a suitable solvent, using an auxiliary base, under the atmosphere of an inert gas, and isolating the resulting condensation product as an acid addition salt with a carboxylic acid, to give a compound of formula wherein R is hydrogen, or the residue of an aliphatic, cycloaliphatic or aromatic monocarboxylic or dicarboxylic acid; b) enantioselective reduction of the benzylamino ketone acid addition salt of Formula III to give a single enantiomer of the benzylamino alcohol of Formula V wherein the carbon atom bearing the waxy bond can be in the or configuration; c) debenzylation of the single enantiomer of the compound of Formula V to give a single enantiomer of norepinephrine, and d) isolating the single enantiomer of norepinephrine as a free base or acid addition salt thereof.
A pump assembly with an electrical drive motor which is arranged in a stator housing and with an electronics housing which is connected to the stator housing and in which at least one circuit board with electronic components is arranged, said components being necessary for the control or closed-loop control of the drive motor, wherein at least one separate connection element which is designed a plastic moulded part is arranged on or in the electronics housing, said connection element being designed as a main connection element and comprising the one first electrical plug connector which is connected to a corresponding electrical plug-in coupling on the circuit board, as well as comprising a second electrical plug connector which is connected to the first electrical plug connector via strip conductors and which is provided for the connection of a mains connection lead and the interior of the electronics housing is delimited by a wall, in which an opening is formed, characterised in that the connection element with its first plug connector extends through the opening into the interior and the second plug connector is arranged outside the interior and in that the electronics housing is designed as a moulded part of plastic in a two-part manner with a lower part and with a cover which is placed upon the lower part.
A separator for an electrochemical device, the separator being interposed between a pair of electrodes and being capable of holding an electrolytic solutions containing an electrolyte, wherein the separator for an electrochemical device consists of only beaten solvent-spun regenerated cellulose fibers, wherein a filament with a fiber diameter of less than 1 μm formed by beating is referred to as a "fibril", and the original fiber with a fiber diameter of 1 μm or more is referred to as a "core", said fibers having a core portion with an average fiber diameter of from 1 to 11 μm, the separator having a thickness of from 5 to 100 μm, a density of from 0.25 to 0.9 g/cm 3, and a curvature rate of from 1.5 to 15, wherein the curvature rate τ is defined as τ = t ⋅ ε ⋅ d / 5.18 ⋅ 10 − 3 ⋅ L 1 / 2 where L denotes the separator thickness (μm), t denotes the Gurley value (s/100 ml), ε denotes the porosity, and d denotes the pore diameter (μm), and wherein the Gurley value is measured by a method specified in 5 Gurley test method of JIS P 8117 "Paper and board - Determination of air permeance and air resistance (medium range) - Gurley method", and the porosity is calculated from the ratio of the density of a separator to the specific gravity of the material of the separator using the following formula: ε = 1 - (D1/D2), where ε denotes the porosity, D1 denotes the density of the separator, and D2 denotes the specific gravity of the material of the separator, and wherein the separator has a Gurley value in the range from 1.5 to 30.1 s/100ml. where L denotes the separator thickness (μm), t denotes the Gurley value (s/100 ml), ε denotes the porosity, and d denotes the pore diameter (μm), and wherein the Gurley value is measured by a method specified in 5 Gurley test method of JIS P 8117 "Paper and board - Determination of air permeance and air resistance (medium range) - Gurley method", and the porosity is calculated from the ratio of the density of a separator to the specific gravity of the material of the separator using the following formula: ε = 1 - (D1/D2), where ε denotes the porosity, D1 denotes the density of the separator, and D2 denotes the specific gravity of the material of the separator, and wherein the separator has a Gurley value in the range from 1.5 to 30.1 s/100ml.
A dip-moulding process for the manufacture of hard capsule shells, comprising: providing an aqueous composition comprising an aqueous dispersion of a functional polymer selected from an enteric polymer excluding cellulose acetate phthalate, said polymer being present in an amount ranging from 5% to 30% by weight of the total weight of said aqueous composition; at least one processing aid present in an amount ranging from 0.1% to 20% by weight of the total weight of said aqueous composition, said processing aid comprising a polyoxyethylene-polyoxypropylene-polyoxyethylene block polymer; and water; adjusting said aqueous composition to a temperature ranging from 5°C to 40°C; pre-heating moulding pins to a dipping temperature ranging from 15°C to 70 °C higher than said temperature T1; dipping the pre-heated moulding pins into said aqueous composition; forming a film on said moulding pins by withdrawing said pins from said aqueous composition; and drying the film on said moulding pins to form hard capsule shells. providing an aqueous composition comprising an aqueous dispersion of a functional polymer selected from an enteric polymer excluding cellulose acetate phthalate, said polymer being present in an amount ranging from 5% to 30% by weight of the total weight of said aqueous composition; at least one processing aid present in an amount ranging from 0.1% to 20% by weight of the total weight of said aqueous composition, said processing aid comprising a polyoxyethylene-polyoxypropylene-polyoxyethylene block polymer; and water; adjusting said aqueous composition to a temperature ranging from 5°C to 40°C; pre-heating moulding pins to a dipping temperature ranging from 15°C to 70 °C higher than said temperature T1; dipping the pre-heated moulding pins into said aqueous composition; forming a film on said moulding pins by withdrawing said pins from said aqueous composition; and an aqueous dispersion of a functional polymer selected from an enteric polymer excluding cellulose acetate phthalate, said polymer being present in an amount ranging from 5% to 30% by weight of the total weight of said aqueous composition; at least one processing aid present in an amount ranging from 0.1% to 20% by weight of the total weight of said aqueous composition, said processing aid comprising a polyoxyethylene-polyoxypropylene-polyoxyethylene block polymer; and water; adjusting said aqueous composition to a temperature ranging from 5°C to 40°C; pre-heating moulding pins to a dipping temperature ranging from 15°C to 70 °C higher than said temperature T1; dipping the pre-heated moulding pins into said aqueous composition; forming a film on said moulding pins by withdrawing said pins from said aqueous composition; and drying the film on said moulding pins to form hard capsule shells.
An isolated antibody that specifically binds to an unsulfated epitope of a human Dkk1 sulfation site but does not substantially bind to the sulfated sulfation site, wherein the sulfation site includes Tyr 83.
A method for laser scribing two transparent electrically conductive layers deposited on opposite surfaces of a transparent substrate comprising: 1. directing a laser beam (64A, 64B, 74A, 74B, 94A, 94B) through one or more lenses (65A, 65B, 75A, 75B, 76A, 76B, 85A, 85B, 95A, 95B, 96A, 96B, 98A, 98B) to a first focal spot (66A, 78A, 86A, 99A) on or closely adjacent an exposed surface (62A, 62B, 72A, 72B, 82A, 82B, 92A, 92B) of a first of the two layers; 2. initiating relative movement between the laser beam and the substrate in two axes in a plane orthogonal to the axis of the laser beam whereby to scribe a first electrode pattern on the first of the two layers; 3. repositioning the one or more lenses and focusing the laser beam through the transparent substrate at a second focal spot (66B, 76B, 86B, 99B) on or closely adjacent an exposed surface (63A, 63B, 73A, 73B, 83A, 83B, 93A, 93B) of the second of the two layers; 4. initiating relative movement between the laser beam and the substrate in two axes in a plane orthogonal to the axis of the laser beam whereby to scribe a second electrode pattern on the second of the two layers, wherein the first and second electrode patterns are different. 1. directing a laser beam (64A, 64B, 74A, 74B, 94A, 94B) through one or more lenses (65A, 65B, 75A, 75B, 76A, 76B, 85A, 85B, 95A, 95B, 96A, 96B, 98A, 98B) to a first focal spot (66A, 78A, 86A, 99A) on or closely adjacent an exposed surface (62A, 62B, 72A, 72B, 82A, 82B, 92A, 92B) of a first of the two layers; 2. initiating relative movement between the laser beam and the substrate in two axes in a plane orthogonal to the axis of the laser beam whereby to scribe a first electrode pattern on the first of the two layers; 3. repositioning the one or more lenses and focusing the laser beam through the transparent substrate at a second focal spot (66B, 76B, 86B, 99B) on or closely adjacent an exposed surface (63A, 63B, 73A, 73B, 83A, 83B, 93A, 93B) of the second of the two layers; 4. initiating relative movement between the laser beam and the substrate in two axes in a plane orthogonal to the axis of the laser beam whereby to scribe a second electrode pattern on the second of the two layers, wherein the first and second electrode patterns are different.
An alignment device (400, 400', 400"), comprising: a mount comprising: a body portion with at least one external curved bearing surface and a tubular mounting portion that includes a connection point for an optical or acoustic transmitter or receiver; and an attachment collar projecting from the body portion and secured to the housing; a housing for the mount that is arranged to allow rotation of the mount within the housing, wherein the housing comprises translation restraining means, the at least one external curved bearing surface for bearing against the translation restraining means during rotation of the mount within the housing for preventing translation of the mount during rotation; adjustment means for adjusting the alignment of the mount within the housing, for alignment of a received source or detector with a desired transmission direction, wherein the adjustment means comprises one or more pairs of opposed screws or bolts that are equally spaced around the circumference of the tubular mounting portion seated in the attachment collar; and rotation restraining means for preventing rotation of the mount about an axis corresponding to the transmission direction, wherein the rotation restraining means comprises a protrusion in the body portion that engages with a slot in the attachment collar. a mount comprising: a body portion with at least one external curved bearing surface and a tubular mounting portion that includes a connection point for an optical or acoustic transmitter or receiver; and an attachment collar projecting from the body portion and secured to the housing; a body portion with at least one external curved bearing surface and a tubular mounting portion that includes a connection point for an optical or acoustic transmitter or receiver; and an attachment collar projecting from the body portion and secured to the housing; a housing for the mount that is arranged to allow rotation of the mount within the housing, wherein the housing comprises translation restraining means, the at least one external curved bearing surface for bearing against the translation restraining means during rotation of the mount within the housing for preventing translation of the mount during rotation; adjustment means for adjusting the alignment of the mount within the housing, for alignment of a received source or detector with a desired transmission direction, wherein the adjustment means comprises one or more pairs of opposed screws or bolts that are equally spaced around the circumference of the tubular mounting portion seated in the attachment collar; and rotation restraining means for preventing rotation of the mount about an axis corresponding to the transmission direction, wherein the rotation restraining means comprises a protrusion in the body portion that engages with a slot in the attachment collar.
A method comprising: receiving, via one or more processors, an indication of an event in a computing system, wherein the event corresponds to a change in the computing system that indicates a current or potential problem within the computing system, wherein the computing system comprises a plurality of elements (112, 114, 122, 124, 132, 134, 142, 144, 210-270, 632, 642, 652, 662, 664, 672); generating a computer readable representation of the computing system using automated topology enumeration, wherein the computer-readable representation represents the plurality of elements of the computing system organized in a hierarchical plurality of network architecture layers (630, 640, 650, 660, 670); identifying, via the one or more processors, an element (632, 662, 664, 672) of the plurality of elements (112, 114, 122, 124, 132, 134, 142, 144, 210-270, 632, 642, 652, 662, 664, 672) based on the computer readable representation of the computing system; determining, via the one or more processors, a value for a metric for the element (632, 662, 664, 672); and in response to determining that the value is outside a range associated with the metric, generating, via the one or more processors, a remediation priority for the element (632, 662, 664, 672) based on a metric weight associated with the metric and a network layer value associated with a network architecture layer from the hierarchical plurality of network architecture layers, wherein the element is associated with a network layer role corresponding to the network architecture layer. receiving, via one or more processors, an indication of an event in a computing system, wherein the event corresponds to a change in the computing system that indicates a current or potential problem within the computing system, wherein the computing system comprises a plurality of elements (112, 114, 122, 124, 132, 134, 142, 144, 210-270, 632, 642, 652, 662, 664, 672); generating a computer readable representation of the computing system using automated topology enumeration, wherein the computer-readable representation represents the plurality of elements of the computing system organized in a hierarchical plurality of network architecture layers (630, 640, 650, 660, 670); identifying, via the one or more processors, an element (632, 662, 664, 672) of the plurality of elements (112, 114, 122, 124, 132, 134, 142, 144, 210-270, 632, 642, 652, 662, 664, 672) based on the computer readable representation of the computing system; determining, via the one or more processors, a value for a metric for the element (632, 662, 664, 672); and in response to determining that the value is outside a range associated with the metric, generating, via the one or more processors, a remediation priority for the element (632, 662, 664, 672) based on a metric weight associated with the metric and a network layer value associated with a network architecture layer from the hierarchical plurality of network architecture layers, wherein the element is associated with a network layer role corresponding to the network architecture layer.
A system for cleaning a gas turbine engine, the gas turbine engine including a plurality of fan blades and a fan casing surrounding the plurality of fan blades, the system comprising: a wash stand, the wash stand comprising a base frame and a plurality of fluid injection nozzles that are supported by the base frame relative to the gas turbine engine, the plurality of fluid injection nozzles are in use configured to inject a cleaning fluid through an inlet of the fan casing as the plurality of fan blades are being rotated in a rotational direction such that the cleaning fluid is directed past the plurality of rotating fan blades and into a compressor inlet of the gas turbine engine; and a fluid source in flow communication with the wash stand supplying the cleaning fluid to the plurality of fluid injection nozzles, characterized in that each fluid injection nozzle is oriented at a positive angle having a tangential component, the tangential component being directed in the rotational direction of the plurality of fan blades. a wash stand, the wash stand comprising a base frame and a plurality of fluid injection nozzles that are supported by the base frame relative to the gas turbine engine, the plurality of fluid injection nozzles are in use configured to inject a cleaning fluid through an inlet of the fan casing as the plurality of fan blades are being rotated in a rotational direction such that the cleaning fluid is directed past the plurality of rotating fan blades and into a compressor inlet of the gas turbine engine; and a fluid source in flow communication with the wash stand supplying the cleaning fluid to the plurality of fluid injection nozzles, characterized in that each fluid injection nozzle is oriented at a positive angle having a tangential component, the tangential component being directed in the rotational direction of the plurality of fan blades.
A composition for use in a method of treating liver fluke infections in a mammal in need of such treatment comprising administering the composition comprising an effective amount of diamphenethide in combination with an effective amount of closantel wherein the mammal is sheep, and wherein the liver fluke infection is Fasciola hepatica or Fasciola gigantica. wherein the mammal is sheep, and wherein the liver fluke infection is Fasciola hepatica or Fasciola gigantica.
A rechargeable lithium battery comprising: a negative electrode comprising a composite negative active material of a metal or semi-metal and a carbonaceous material; a positive electrode comprising a mixed positive active material of about 90 to about 99 wt % of a first positive active material selected from the group consisting of cobalt, manganese, phosphate-based materials, or combinations thereof, and about 1 to 10 wt % of a nickel-based second positive active material; and a non-aqueous electrolyte; wherein the metal or semi-metal is one metal or alloy selected from the group consisting of Si, an Si-T alloy (where T is an element selected from an alkali metal, an alkaline-earth metal, a group 13 element, a group 14 element, a transition element, a rare earth element, or combinations thereof, and is not Si), Sn, an Sn-Z alloy (where Z is an element selected from an alkali metal, an alkaline-earth metal, a group 13 element, a group 14 element, a transition element, a rare earth element, or combinations thereof and is not Sn), Pb, In, As, Sb, Ag, or combinations thereof. a negative electrode comprising a composite negative active material of a metal or semi-metal and a carbonaceous material; a positive electrode comprising a mixed positive active material of about 90 to about 99 wt % of a first positive active material selected from the group consisting of cobalt, manganese, phosphate-based materials, or combinations thereof, and about 1 to 10 wt % of a nickel-based second positive active material; and a non-aqueous electrolyte; wherein the metal or semi-metal is one metal or alloy selected from the group consisting of Si, an Si-T alloy (where T is an element selected from an alkali metal, an alkaline-earth metal, a group 13 element, a group 14 element, a transition element, a rare earth element, or combinations thereof, and is not Si), Sn, an Sn-Z alloy (where Z is an element selected from an alkali metal, an alkaline-earth metal, a group 13 element, a group 14 element, a transition element, a rare earth element, or combinations thereof and is not Sn), Pb, In, As, Sb, Ag, or combinations thereof.
A stiffening assembly for stiffening an article, the stiffening assembly comprising a plurality of main modules arrangeable on the article, each main module comprising: a body defining a longitudinal central axis, a receiving formation within the body, and a longitudinally extending elongate outer opening to allow access of the article to the receiving formation, wherein the body has opposite ends (20, 22) and the central axis extends between said opposite ends (20, 22); wherein the receiving formation defines an internal space for receiving the portion of the article therethrough, and wherein the receiving formation has a longitudinal subsidiary central axis, characterised in that the longitudinal subsidiary central axis of the receiving formation is offset from the main central axis of the body. a body defining a longitudinal central axis, a receiving formation within the body, and a longitudinally extending elongate outer opening to allow access of the article to the receiving formation, wherein the body has opposite ends (20, 22) and the central axis extends between said opposite ends (20, 22); wherein the receiving formation defines an internal space for receiving the portion of the article therethrough, and wherein the receiving formation has a longitudinal subsidiary central axis, characterised in that the longitudinal subsidiary central axis of the receiving formation is offset from the main central axis of the body.
A two wheeled vehicle with a first wheel and a second wheel, the first and second wheels having a respective axis of rotation, the axes of rotation being non-aligned with each other, the two wheeled vehicle comprising: a first electrical motor operable to drivingly rotate the first wheel; a second electrical motor operable to drivingly rotate the second wheel; and a controller operable to independently control the first and second electrical motors to drive rotation of the first and second wheels independent of each other, characterised in that the controller is operable to compare a current level of the first and second electrical motors, and wherein the controller is operable to independently control the first and second electrical motors to maintain the current levels of the first and second electrical motors within a predetermined range of each other. a first electrical motor operable to drivingly rotate the first wheel; a second electrical motor operable to drivingly rotate the second wheel; and a controller operable to independently control the first and second electrical motors to drive rotation of the first and second wheels independent of each other, characterised in that the controller is operable to compare a current level of the first and second electrical motors, and wherein the controller is operable to independently control the first and second electrical motors to maintain the current levels of the first and second electrical motors within a predetermined range of each other.