A soybean extract composition and optional pharmaceutically acceptable carrier or excipient for use in alleviating skin pain caused by skin inflammation induced by cancer radiation therapy by means of topical application to the site of pain and/or the site of inflammation, wherein the soybean extract composition comprises a soybean seed extract and a soybean vapor fraction, which soybean seed extract is prepared by a process comprising steps of: (a) providing soybean seeds and an extracting solution, which extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 90 wt%; (b) extracting the soybean seeds with the extracting solution at a barometric pressure lower than or equal to about 101.325 kPa and at a temperature lower than about 60°C to obtain an crude extract; and (c) removing solids from the crude extract to obtain a liquid portion; which soybean seed vapor fraction is prepared by a process comprising steps of: (i) providing soybean seeds in a second extracting solution, which second extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 15 wt%; and (ii) extracting the soybean seeds with the second extracting solution at a barometric pressure lower than about 101.325 kPa and at a temperature lower than about 110°C and collecting the vapor fraction. which soybean seed extract is prepared by a process comprising steps of: (a) providing soybean seeds and an extracting solution, which extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 90 wt%; (b) extracting the soybean seeds with the extracting solution at a barometric pressure lower than or equal to about 101.325 kPa and at a temperature lower than about 60°C to obtain an crude extract; and (c) removing solids from the crude extract to obtain a liquid portion; (a) providing soybean seeds and an extracting solution, which extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 90 wt%; (b) extracting the soybean seeds with the extracting solution at a barometric pressure lower than or equal to about 101.325 kPa and at a temperature lower than about 60°C to obtain an crude extract; and (c) removing solids from the crude extract to obtain a liquid portion; which soybean seed vapor fraction is prepared by a process comprising steps of: (i) providing soybean seeds in a second extracting solution, which second extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 15 wt%; and (ii) extracting the soybean seeds with the second extracting solution at a barometric pressure lower than about 101.325 kPa and at a temperature lower than about 110°C and collecting the vapor fraction. (i) providing soybean seeds in a second extracting solution, which second extracting solution is water or an alcohol solution containing alcohol at the concentration lower than about 15 wt%; and (ii) extracting the soybean seeds with the second extracting solution at a barometric pressure lower than about 101.325 kPa and at a temperature lower than about 110°C and collecting the vapor fraction.