A package of an isolation device for providing a sterile operation chamber above a skin region of a patient and a device for producing and maintaining a sterile surface on said patient's skin, said device for producing and maintaining a sterile surface comprising: a first frame having first frame elements (11a-d) encompassing a first inner operation opening allowing access through said first frame from a top side of the first frame to a bottom side of the first frame, said first frame elements having a downward first adhesion surface including an adhesive material adapted to adhere said first adhesion surface to the patient's skin; a first foil, attached to the first frame and extending across said inner operation opening; wherein a fluid channel is provided in said first frame, said fluid channel being in fluid communication with a connector for injecting fluid into said fluid channel, wherein said fluid channel opens into a space between the bottom side of the first frame and the first foil to allow flooding of a space defined between the first foil and the patient's skin if the first frame is attached to said patient's skin, said isolation device comprising a first inflatable bag, the first inflatable bag delimiting said sterile operation chamber against the ambient environment, said first inflatable bag comprising: a first and a second access opening (105,106) to allow a user to insert a first and a second arm into the operation chamber; and a chamber operation opening to allow access to said skin region of the patient out of the operation chamber; and a window for observing handling operations inside said sterile operation chamber wherein the first inflatable bag is coupled to a support frame (110,120), the support frame having a transport configuration and an operation configuration, wherein in the transport configuration, the first inflatable bag is confined, such as to have compact dimensions; in the operation configuration, the first inflatable bag is extended, such as to form said sterile operation chamber, wherein said isolation device is attached to the first frame in a confined, packed condition such that the upper surface of the first foil is kept in asterile environment. a first frame having first frame elements (11a-d) encompassing a first inner operation opening allowing access through said first frame from a top side of the first frame to a bottom side of the first frame, said first frame elements having a downward first adhesion surface including an adhesive material adapted to adhere said first adhesion surface to the patient's skin; a first foil, attached to the first frame and extending across said inner operation opening; wherein a fluid channel is provided in said first frame, said fluid channel being in fluid communication with a connector for injecting fluid into said fluid channel, wherein said fluid channel opens into a space between the bottom side of the first frame and the first foil to allow flooding of a space defined between the first foil and the patient's skin if the first frame is attached to said patient's skin, said isolation device comprising a first inflatable bag, the first inflatable bag delimiting said sterile operation chamber against the ambient environment, said first inflatable bag comprising: a first and a second access opening (105,106) to allow a user to insert a first and a second arm into the operation chamber; and a chamber operation opening to allow access to said skin region of the patient out of the operation chamber; and a window for observing handling operations inside said sterile operation chamber wherein the first inflatable bag is coupled to a support frame (110,120), the support frame having a transport configuration and an operation configuration, wherein in the transport configuration, the first inflatable bag is confined, such as to have compact dimensions; in the operation configuration, the first inflatable bag is extended, such as to form said sterile operation chamber, a first inflatable bag, the first inflatable bag delimiting said sterile operation chamber against the ambient environment, said first inflatable bag comprising: a first and a second access opening (105,106) to allow a user to insert a first and a second arm into the operation chamber; and a chamber operation opening to allow access to said skin region of the patient out of the operation chamber; and a first and a second access opening (105,106) to allow a user to insert a first and a second arm into the operation chamber; and a chamber operation opening to allow access to said skin region of the patient out of the operation chamber; and a window for observing handling operations inside said sterile operation chamber wherein the first inflatable bag is coupled to a support frame (110,120), the support frame having a transport configuration and an operation configuration, wherein in the transport configuration, the first inflatable bag is confined, such as to have compact dimensions; in the operation configuration, the first inflatable bag is extended, such as to form said sterile operation chamber, wherein said isolation device is attached to the first frame in a confined, packed condition such that the upper surface of the first foil is kept in asterile environment.