mhurhangee/ep-ind-claims huggingface dataset:
A process for the preparation of the (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivative of formula I wherein R 1 is selected from C 1-4 -alkyl, comprising the steps a) transforming the -2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative of formula II wherein R 2 is phenyl or C 1-4 -alkyl into the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III wherein R 2 is phenyl or C 1-4 -alkyl b) coupling the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III with N-benzoyl cytosine of formula VIa to form the (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV wherein R 2 is as above and Bz is benzoyl c) alcoholysis of (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV to afford the (2'R)-2'-deoxy-2'-fluoro-2'-methyl-cytidine of formula V and d) acylating the (2'R)-2'-deoxy-2'-fluoro-2'-methyl-cytisdine of formula V to form the (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivative of formula I, characterized in that the coupling step b) comprises b 1) the silylation of N-benzoyl cytosine of formula VIa to form the silylated N-benzoyl cytosine of formula VIb in the presence of a C 3-4 -alkylacetate as solvent and b 2) the coupling of the silylated N-benzoyl cytosine f formula VIb with the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III wherein R 2 is phenyl or C 1-4 -alkyl, to form the (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV wherein R 2 is as above and Bz is benzoyl, in the presence of dichloromethane as solvent and a Lewis acid. a) transforming the -2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative of formula II wherein R 2 is phenyl or C 1-4 -alkyl into the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III wherein R 2 is phenyl or C 1-4 -alkyl b) coupling the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III with N-benzoyl cytosine of formula VIa to form the (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV wherein R 2 is as above and Bz is benzoyl c) alcoholysis of (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV to afford the (2'R)-2'-deoxy-2'-fluoro-2'-methyl-cytidine of formula V and d) acylating the (2'R)-2'-deoxy-2'-fluoro-2'-methyl-cytisdine of formula V to form the (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine derivative of formula I, b 1) the silylation of N-benzoyl cytosine of formula VIa to form the silylated N-benzoyl cytosine of formula VIb in the presence of a C 3-4 -alkylacetate as solvent and b 2) the coupling of the silylated N-benzoyl cytosine f formula VIb with the -2-deoxy-2-fluoro-2-methyl-D-ribofuranosyl chloride of formula III wherein R 2 is phenyl or C 1-4 -alkyl, to form the (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-cytidine derivative of formula IV wherein R 2 is as above and Bz is benzoyl, in the presence of dichloromethane as solvent and a Lewis acid.
A computer-implemented sound processing method for imparting a sound expression to an audio signal generated based on note data representative of each note in a series of notes comprising: specifying, in accordance with the note data, in the audio signal an expression period to which the sound expression is to be imparted, and, from among a plurality of expression samples corresponding to different types of sound expressions, an expression sample representative of the sound expression to be imparted to the expression period; specifying, in accordance with the expression sample and the expression period, a processing parameter for an expression imparting processing for imparting the sound expression to the expression period in the audio signal; and performing the expression imparting processing to the audio signal in accordance with the expression sample, the expression period, and the processing parameter. specifying, in accordance with the note data, in the audio signal an expression period to which the sound expression is to be imparted, and, from among a plurality of expression samples corresponding to different types of sound expressions, an expression sample representative of the sound expression to be imparted to the expression period; specifying, in accordance with the expression sample and the expression period, a processing parameter for an expression imparting processing for imparting the sound expression to the expression period in the audio signal; and performing the expression imparting processing to the audio signal in accordance with the expression sample, the expression period, and the processing parameter.
An order-picking installation (10, 10', 10", 10′′′) for the order-picking of different goods, in particular goods that are capable of being transported in a suspended state, said order-picking installation (10, 10', 10", 10′′′) comprising at least one supply station having a plurality of supply locations (35, 36) which for supplying the goods to be order-picked to the order-picking installation (10, 10', 10", 10′′′) are disposed in parallel, as well as at least one dispatch station having a plurality of dispatch locations which for dispensing the order-picked goods for dispatch are disposed in parallel, wherein at least one temporary store (12; 12.1, 12.2; 12a-d) is provided for order-picking the goods between the supply station and the dispatch station, wherein the at least one temporary store (12; 12.1, 12.2; 12a-d) has a dynamic store for temporarily storing the goods provided for the order-picking, and a standby store, downstream of the dynamic store, for storing goods which are retrieved from the dynamic store and thereby pre-sorted and which are disposed within a common continuous conveyor and are connected to each other by way of the common continuous conveyor, wherein the continuous conveyor comprises a plurality of conveyor sections (20a-d), and in that the dynamic store and the standby store are in each case formed by a plurality of storage sections (23, 26) which as branches depart from predefined conveyor sections (20a, 20c) of the continuous conveyor, which comprise in each case one entry and one exit, and in that the storage sections (23, 26) by way of the entry are in each case connected to a first conveyor section (20a, or 20c, respectively), and by way of the exit are in each case connected to a second conveyor section (20c, or 20a, respectively), wherein the conveying directions of the first (20a respectively 20c) and the second (20c respectively 20a) conveyor section are mutually opposed and in that each of the storage sections (23, 26) are connected to the associated conveyor sections (20a, 20c) of the continuous conveyor at the entry side by way of an activatable egress turnout (22, 25) and at the exit by way of an activatable access turnout (24, 27), characterized in that the storage sections (23, 26) are in each case configured as gravity sections which comprise a gradient from the entry to the exit, and on which the conveyed goods by virtue of gravity move in a self-acting manner from the entry to the exit.
An ophthalmic composition which is an aqueous composition having pH between 7 and 7.4, osmolarity between 280 and 300 mOsm/l, and which comprises one or more glycosaminoglycans (GAGs) in amounts ranging between 0.1 and 5% w/w, polyvinyl alcohol in a concentration between 0.1 and 0.5% w/w, glycerol in amounts ranging between 0.5 and 1% w/w, sodium chloride between 0.01 and 1% w/w, disodium phosphate between 0.1 and 1% w/w, wherein said composition has a contact angle measured over a Kapton surface in the range of 50° to 80°, wherein said contact angle is measured as a static contact angle by means of the sessile drop method with the instrument Contact Angle System OCAE15, wherein the drop has a volume of 3 μl and the deposition rate is 1 μl/s, wherein the measurement time after the drop deposition is 50 seconds.
An image processing apparatus, wherein the image processing apparatus has a reading unit for reading an original and is provided with a plurality of color-monochrome conversion methods which are used when converting a color image into a monochrome image and which have different blend ratios of RGB components of the color image, and wherein the image processing apparatus comprises: determining means for determining whether a job is a scan job formed by reading an original with the reading unit or a job input from an external apparatus; and converting means for converting a color image into a monochrome image, wherein if the determining means determines that the job is a scan job formed by reading an original with the reading unit, the converting means converts a color image formed from the scan job into a monochrome image using, from among the plurality of color-monochrome conversion methods, one color-monochrome conversion method in which the ratio of the B component is smaller than those in the other color-monochrome conversion methods, and wherein if the determining means determines that the job is a job input from an external apparatus, the converting means converts a color image formed from the job into a monochrome image using a color-monochrome conversion method selected, from among the plurality of color-monochrome conversion methods, via an operation unit provided in the external apparatus or in the image processing apparatus. determining means for determining whether a job is a scan job formed by reading an original with the reading unit or a job input from an external apparatus; and converting means for converting a color image into a monochrome image, wherein if the determining means determines that the job is a scan job formed by reading an original with the reading unit, the converting means converts a color image formed from the scan job into a monochrome image using, from among the plurality of color-monochrome conversion methods, one color-monochrome conversion method in which the ratio of the B component is smaller than those in the other color-monochrome conversion methods, and wherein if the determining means determines that the job is a job input from an external apparatus, the converting means converts a color image formed from the job into a monochrome image using a color-monochrome conversion method selected, from among the plurality of color-monochrome conversion methods, via an operation unit provided in the external apparatus or in the image processing apparatus.
A method for reprofiling a worn wheel of a railway vehicle, said wheel including a contact surface intended to come into contact with a rail during the displacement of the railway vehicle, characterized: - in that it includes, without disassembling the wheel of the railway vehicle, a step consisting of adding an additional material over at least one worn area of said contact surface of the wheel, the additional material comprising a metal powder; - in that the addition of the additional material in the worn area is carried out by depositing successive layers; and - in that the step consisting of adding an additional material in the worn area comprises the application of an additive manufacturing technique consisting of melting or sintering each following metal powder layer with a preceding metal powder layer. - in that it includes, without disassembling the wheel of the railway vehicle, a step consisting of adding an additional material over at least one worn area of said contact surface of the wheel, the additional material comprising a metal powder; - in that the addition of the additional material in the worn area is carried out by depositing successive layers; and - in that the step consisting of adding an additional material in the worn area comprises the application of an additive manufacturing technique consisting of melting or sintering each following metal powder layer with a preceding metal powder layer.
An apparatus for seismic surveying, comprising: a hydraulically actuated seismic source that includes a reaction mass; a base plate acted on by the reaction mass when driven by the seismic source to generate a pulse having an amplitude sustained over a predefined time period, the base plate having a bottom surface configured to contact a surface of the ground and apply a force to the ground in a downward vertical direction to generate the pulse; characterized in that the apparatus further comprises: a coupler connectable to the bottom surface of the base plate, the coupler projecting downward from the base plate and configured to contain soil under the base plate, wherein the coupler includes at least one downwardly projecting wall that is formed along the perimeter of the coupler; and a vibrator truck on which the seismic source is positioned, the vibrator truck having a first configuration wherein only the bottom surface of the base plate contacts the ground and a second configuration wherein the coupler and the bottom surface of the base plate contact the ground, wherein the coupler is configured to be removed from the base plate and is removed from the base plate in the first configuration. a hydraulically actuated seismic source that includes a reaction mass; a base plate acted on by the reaction mass when driven by the seismic source to generate a pulse having an amplitude sustained over a predefined time period, the base plate having a bottom surface configured to contact a surface of the ground and apply a force to the ground in a downward vertical direction to generate the pulse; characterized in that the apparatus further comprises: a coupler connectable to the bottom surface of the base plate, the coupler projecting downward from the base plate and configured to contain soil under the base plate, wherein the coupler includes at least one downwardly projecting wall that is formed along the perimeter of the coupler; and a vibrator truck on which the seismic source is positioned, the vibrator truck having a first configuration wherein only the bottom surface of the base plate contacts the ground and a second configuration wherein the coupler and the bottom surface of the base plate contact the ground, wherein the coupler is configured to be removed from the base plate and is removed from the base plate in the first configuration. a coupler connectable to the bottom surface of the base plate, the coupler projecting downward from the base plate and configured to contain soil under the base plate, wherein the coupler includes at least one downwardly projecting wall that is formed along the perimeter of the coupler; and a vibrator truck on which the seismic source is positioned, the vibrator truck having a first configuration wherein only the bottom surface of the base plate contacts the ground and a second configuration wherein the coupler and the bottom surface of the base plate contact the ground, wherein the coupler is configured to be removed from the base plate and is removed from the base plate in the first configuration.
Composite glass unit comprising at least a first glass sheet and a second glass sheet as well as a third glass sheet arranged between the first glass sheet and the second glass sheet, the third glass sheet having at least one cutout for receiving a connecting element, a first bonding layer arranged between the first glass sheet and the third glass sheet for connecting the first glass sheet to the third glass sheet, and a second bonding layer arranged between the second glass sheet and the third glass sheet for connecting the second glass sheet to the third glass sheet, as well as a connecting element, which is introduced into the at least one cutout in the third glass sheet, wherein a first surface of the connecting element facing the first glass sheet is connected to the first glass sheet via the first bonding layer and/or a second surface of the connecting element facing the second glass sheet is connected to the second glass sheet via the second bonding layer, characterized in that between the or each end surface of the connecting element facing in the direction of the third glass sheet and the third glass sheet a separating layer is inserted, which is different from the bonding layers (5, 6) and does not rigidly connecting the connecting element and the third glass sheet, the Shore-A-hardness of the separating layer being significantly below the Shore-A-hardness of the bonding layer (5, 6) and/or the adhesion between the separating layer and the connecting element and/or the adhesion between the separating layer and the glass sheets (2, 3, 4) being significantly lower than the adhesion of the connecting layers (5, 6) and the connecting element or the adhesion of the bonding layers (5, 6) and the glass sheets (2, 3, 4).
A method for counting cells of various types in the blood, comprising receiving a whole blood sample of a person or animal at or near a sensor surface of a contact microscope device, the whole blood sample comprising blood cells of two or more types; deriving morphometric information about the blood cells in the blood sample at a resolution of 5 microns or smaller using a two-dimensional array of light sensitive elements of the contact microscope that are configured and disposed to be sensitive to light at the sensor surface, the morphometric information including a shape of the blood cells of each of the two or more types; and generating a blood count of blood cells of each of the two or more types in the sample using the derived morphometric information, wherein generating the blood count comprises counting the blood cells of each of the two or more types using the derived morphometric information including the shape of the blood cells of each of the two or more types to differentiate the blood cells of each of the two or more types. receiving a whole blood sample of a person or animal at or near a sensor surface of a contact microscope device, the whole blood sample comprising blood cells of two or more types; deriving morphometric information about the blood cells in the blood sample at a resolution of 5 microns or smaller using a two-dimensional array of light sensitive elements of the contact microscope that are configured and disposed to be sensitive to light at the sensor surface, the morphometric information including a shape of the blood cells of each of the two or more types; and generating a blood count of blood cells of each of the two or more types in the sample using the derived morphometric information, wherein generating the blood count comprises counting the blood cells of each of the two or more types using the derived morphometric information including the shape of the blood cells of each of the two or more types to differentiate the blood cells of each of the two or more types.
A method of bonding a shear web to a wind turbine blade shell, the shear web comprising a web and a mounting flange oriented transverse to the web, wherein the method comprises: providing a seal around a periphery of the mounting flange; applying adhesive to an inner surface of the blade shell or to the mounting flange; positioning the shear web relative to the blade shell, after the step of applying adhesive, such that the mounting flange is in mutually opposed relation with the inner surface of the blade shell and such that the seal defines a substantially enclosed cavity between the mounting flange and the inner surface of the blade shell, the cavity containing the adhesive; evacuating air from the cavity such that the mounting flange and the blade shell are forced together under the influence of a vacuum or partial vacuum in the enclosed cavity; and curing the adhesive. providing a seal around a periphery of the mounting flange; applying adhesive to an inner surface of the blade shell or to the mounting flange; positioning the shear web relative to the blade shell, after the step of applying adhesive, such that the mounting flange is in mutually opposed relation with the inner surface of the blade shell and such that the seal defines a substantially enclosed cavity between the mounting flange and the inner surface of the blade shell, the cavity containing the adhesive; evacuating air from the cavity such that the mounting flange and the blade shell are forced together under the influence of a vacuum or partial vacuum in the enclosed cavity; and curing the adhesive.
A method, implemented at a computer system that includes one or more processors, for protecting sensitive information in connection with tracing an original execution of an entity, the method comprising: accessing trace data that represents execution of a plurality of executable instructions of the entity; based on the trace data, identifying that original information, which was accessed based on execution of one or more first executable instructions of the entity, comprises sensitive information; identifying derived information of the original information, the identifying being based on identifying execution of one or more second executable instructions of the entity that operate on the original information to create the derived information; based on the derived information being derived from the original information, determining that the derived information also comprises sensitive information; and based on the derived information comprising the sensitive information, performing one or more of: storing first trace data comprising alternative information, rather than the derived information, while ensuring that an execution path that was taken by the entity based on the derived information will also be taken during replay of the entity; or storing second trace data that causes one or more alternative executable instructions, rather than the one or more second executable instructions of the entity, to be executed during the replay of the entity. accessing trace data that represents execution of a plurality of executable instructions of the entity; based on the trace data, identifying that original information, which was accessed based on execution of one or more first executable instructions of the entity, comprises sensitive information; identifying derived information of the original information, the identifying being based on identifying execution of one or more second executable instructions of the entity that operate on the original information to create the derived information; based on the derived information being derived from the original information, determining that the derived information also comprises sensitive information; and based on the derived information comprising the sensitive information, performing one or more of: storing first trace data comprising alternative information, rather than the derived information, while ensuring that an execution path that was taken by the entity based on the derived information will also be taken during replay of the entity; or storing second trace data that causes one or more alternative executable instructions, rather than the one or more second executable instructions of the entity, to be executed during the replay of the entity.
A detection system for electrochemically detecting cancer antigen 125 (CA-125), comprising: a microelectrode including a linker on its surface, wherein the linker is attached to an antibody or fragment thereof capable of binding CA-125, the microelectrode having a diameter of 100 microns or less; and a redox reporter capable of electron transfer with the microelectrode, wherein binding of CA-125 to the antibody or fragment thereof hinders the electron transfer between the redox reporter and the microelectrode. a microelectrode including a linker on its surface, wherein the linker is attached to an antibody or fragment thereof capable of binding CA-125, the microelectrode having a diameter of 100 microns or less; and a redox reporter capable of electron transfer with the microelectrode, wherein binding of CA-125 to the antibody or fragment thereof hinders the electron transfer between the redox reporter and the microelectrode.