A compound of Formula I: wherein: A is a heteroaryl selected from the group consisting of benzimidazolyl, azaindolyl, quinolinyl, benzothienyl, benzoxazolyl, thienyl and benzothiazolyl; R 1 for each occurrence, is independently halogen, C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkoxy, -S-C 1-6 -alkyl, S-C 6-10 -aryl, C 6-10 -aryl, C 6-10 -aryl-C 1-6 -alkyloxy, heteroaryl, heterocyclyl, C 6-10 aryloxy, heteroaryloxy, heterocyclyloxy, cyano, NR a R b, nitro, C -C 1-6 -alkyl, C O-C 1-6 -alkyl, C O-C 6-10 aryl, C O-heteroaryl, C NR a R b,NR a C - C 1-6 -alkyl, NR a C -C 6-10 -aryl, NR a C -heteroaryl, NR a -heterocyclyl, carboxy, sulfonyl, sulfamoyl or sulfonamido, in which each alkyl, alkoxy, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more groups selected from the group consisting of halo, C 1-6 -alkyl, C 1-6 -alkoxy, hydroxy, halo-C 1-6 -alkyl, C 6-10 -aryl, heteroaryl, C 6-10 -aryloxy and C 3-7 cycloalkyl; R a and R b for each occurrence, are independently H, C 1-6 -alkyl, C 3-7 -cycloalkyl, C 6-10 -aryl, heterocyclyl, heteroaryl or R a and R b which are attached to the same nitrogen may form together with the nitrogen to which they are attached a 5- to 7-membered saturated heterocyclyl; R 2 is H, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkyl, C 3-7 -cycloalkyl, cyano, or halogen; R 3 and R 4 are independently H, C 1-6 -alkyl or C 3-7 cycloalkyl; wherein alkyl can be optionally substituted with C 1-6 alkoxy, halogen, hydroxy, or R 3 and R 4 can form together with the atoms to which they are attached a 4- to 7-membered heterocyclyl or a 3- to 7-membered cycloalkyl; and when A is benzothiazolyl then one of R 3, R 4 is other than H; R 5 is H or C 1-6 -alkyl; or R 5 and R 3 or R 5 and R 4 form together with the atoms to which they are attached a 4- to 7-membered saturated heterocyclyl; or R 5 and R 2 form together with the atoms to which they are attached a 5- to 7- membered ring saturated heterocyclyl which may be optionally substituted with oxo; n is 0, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof. A is a heteroaryl selected from the group consisting of benzimidazolyl, azaindolyl, quinolinyl, benzothienyl, benzoxazolyl, thienyl and benzothiazolyl; R 1 for each occurrence, is independently halogen, C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkoxy, -S-C 1-6 -alkyl, S-C 6-10 -aryl, C 6-10 -aryl, C 6-10 -aryl-C 1-6 -alkyloxy, heteroaryl, heterocyclyl, C 6-10 aryloxy, heteroaryloxy, heterocyclyloxy, cyano, NR a R b, nitro, C -C 1-6 -alkyl, C O-C 1-6 -alkyl, C O-C 6-10 aryl, C O-heteroaryl, C NR a R b,NR a C - C 1-6 -alkyl, NR a C -C 6-10 -aryl, NR a C -heteroaryl, NR a -heterocyclyl, carboxy, sulfonyl, sulfamoyl or sulfonamido, in which each alkyl, alkoxy, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more groups selected from the group consisting of halo, C 1-6 -alkyl, C 1-6 -alkoxy, hydroxy, halo-C 1-6 -alkyl, C 6-10 -aryl, heteroaryl, C 6-10 -aryloxy and C 3-7 cycloalkyl; R a and R b for each occurrence, are independently H, C 1-6 -alkyl, C 3-7 -cycloalkyl, C 6-10 -aryl, heterocyclyl, heteroaryl or R a and R b which are attached to the same nitrogen may form together with the nitrogen to which they are attached a 5- to 7-membered saturated heterocyclyl; R 2 is H, C 1-6 -alkyl, C 1-6 -alkoxy, halo-C 1-6 -alkyl, C 3-7 -cycloalkyl, cyano, or halogen; R 3 and R 4 are independently H, C 1-6 -alkyl or C 3-7 cycloalkyl; wherein alkyl can be optionally substituted with C 1-6 alkoxy, halogen, hydroxy, or R 3 and R 4 can form together with the atoms to which they are attached a 4- to 7-membered heterocyclyl or a 3- to 7-membered cycloalkyl; and when A is benzothiazolyl then one of R 3, R 4 is other than H; R 5 is H or C 1-6 -alkyl; or R 5 and R 3 or R 5 and R 4 form together with the atoms to which they are attached a 4- to 7-membered saturated heterocyclyl; or R 5 and R 2 form together with the atoms to which they are attached a 5- to 7- membered ring saturated heterocyclyl which may be optionally substituted with oxo; n is 0, 1, 2, 3, 4 or 5;