A medical device system, comprising: at least one kinetic sensor, each said sensor configured to collect at least one kinetic signal from a patient; an activity level module configured to determine an activity level of said patient, based at least in part on said at least one kinetic signal; at least one sensor configured to sense a body signal; a body index determination module configured to determine a first body index based on a first sensed body signal and a second body index based on a second sensed body signal; a body index range module, configured to determine a first non-pathological body index range for said first body index and a second non-pathological body index range for said second body index, based at least in part on said activity level; a pathological state determination module, configured to determine that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the first body index is within said first non-pathological body index range and the second body index is within said second non-pathological body index range, and said patient is determined to be in a pathological state if the first body index is outside said first non-pathological body index range and the second body index is outside said second non-pathological body index range; and an additional factor module configured to determine one or more of a time of day and an indicator of a patient's level of consciousness and provide an output relating to said determination; and wherein the body index range module is configured to dynamically adjust the non-pathological body index range based on the determined activity level; and the body index range module is further configured to determine the first non-pathological body index range for the first body index and the second non-pathological body index range for the second body index based at least in part on said output of said additional factor module. at least one kinetic sensor, each said sensor configured to collect at least one kinetic signal from a patient; an activity level module configured to determine an activity level of said patient, based at least in part on said at least one kinetic signal; at least one sensor configured to sense a body signal; a body index determination module configured to determine a first body index based on a first sensed body signal and a second body index based on a second sensed body signal; a body index range module, configured to determine a first non-pathological body index range for said first body index and a second non-pathological body index range for said second body index, based at least in part on said activity level; a pathological state determination module, configured to determine that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the first body index is within said first non-pathological body index range and the second body index is within said second non-pathological body index range, and said patient is determined to be in a pathological state if the first body index is outside said first non-pathological body index range and the second body index is outside said second non-pathological body index range; and an additional factor module configured to determine one or more of a time of day and an indicator of a patient's level of consciousness and provide an output relating to said determination; and wherein the body index range module is configured to dynamically adjust the non-pathological body index range based on the determined activity level; and the body index range module is further configured to determine the first non-pathological body index range for the first body index and the second non-pathological body index range for the second body index based at least in part on said output of said additional factor module.