A method of determining the concentration of one or more analytes in a sample, said method comprising: a) providing a plurality of calibration standards for each of said one or more analytes, each of said calibration standards containing a known concentration of the one or more analytes; b) providing a mass spectrometer; c) providing a digital computer operably connected to said mass spectrometer, said digital computer comprising a processing unit, a data I/O controller for receiving and sending information to and from said mass spectrometer, a display member, and a data storage device; d) determining a peak area value for each of said one or more analytes in each of said calibration standards by analyzing each of said calibration standards containing the known concentration in said mass spectrometer and for each of said one or more analytes, associating each of said peak area value with its corresponding calibration standard concentration as a calibration point pair in said data storage device; e) for each of said one or more analytes, using said processing unit to identify a subset of calibration point pairs, for use in generating a calibration curve, that best fits a predefined curve fit type, the subset of calibration point pairs being pairs at consecutive concentration levels and the determination of best fit being performed by use of a first curve fit metric; f) for each of said one or more analytes, using said processing unit to increase the number of calibration point pairs in the subset, by testing whether the inclusion of one or more additional calibration point pairs at a next immediate concentration level either higher or lower than the subset and any other calibration point pair previously tested would result in the generation of a suitable calibration curve by way of a second curve fit metric, and including said additional calibration point pair into said subset if it is; g) repeating step f) until all calibration point pairs for each of said one or more analytes have been tested; h) for each of said one or more analytes, using said processing unit to create a calibration curve from the resulting subset of calibration point pairs by determining coefficients and/or exponents of a model equation of said predefined curve fit type and storing said coefficients and/or exponents of the model equation in the data storage device; i) performing a mass spectrometer analysis on the sample, the sample containing or suspected of containing an unknown concentration of the one or more of the analytes and obtaining an unknown peak area value for each of the one or more analytes; j) for each of the one or more analytes, using said processing unit to correlate the unknown peak area value to a determined concentration using said model equation; k) outputting said determined concentration for each of said one or more analytes on said display member. a) providing a plurality of calibration standards for each of said one or more analytes, each of said calibration standards containing a known concentration of the one or more analytes; b) providing a mass spectrometer; c) providing a digital computer operably connected to said mass spectrometer, said digital computer comprising a processing unit, a data I/O controller for receiving and sending information to and from said mass spectrometer, a display member, and a data storage device; d) determining a peak area value for each of said one or more analytes in each of said calibration standards by analyzing each of said calibration standards containing the known concentration in said mass spectrometer and for each of said one or more analytes, associating each of said peak area value with its corresponding calibration standard concentration as a calibration point pair in said data storage device; e) for each of said one or more analytes, using said processing unit to identify a subset of calibration point pairs, for use in generating a calibration curve, that best fits a predefined curve fit type, the subset of calibration point pairs being pairs at consecutive concentration levels and the determination of best fit being performed by use of a first curve fit metric; f) for each of said one or more analytes, using said processing unit to increase the number of calibration point pairs in the subset, by testing whether the inclusion of one or more additional calibration point pairs at a next immediate concentration level either higher or lower than the subset and any other calibration point pair previously tested would result in the generation of a suitable calibration curve by way of a second curve fit metric, and including said additional calibration point pair into said subset if it is; g) repeating step f) until all calibration point pairs for each of said one or more analytes have been tested; h) for each of said one or more analytes, using said processing unit to create a calibration curve from the resulting subset of calibration point pairs by determining coefficients and/or exponents of a model equation of said predefined curve fit type and storing said coefficients and/or exponents of the model equation in the data storage device; i) performing a mass spectrometer analysis on the sample, the sample containing or suspected of containing an unknown concentration of the one or more of the analytes and obtaining an unknown peak area value for each of the one or more analytes; j) for each of the one or more analytes, using said processing unit to correlate the unknown peak area value to a determined concentration using said model equation; k) outputting said determined concentration for each of said one or more analytes on said display member.