mhurhangee/ep-ind-claims huggingface dataset:
A method of improving the aggregation propensity and the productivity of an immunoglobulin, comprising; identifying a parent immunoglobulin having a VL domain and a VH domain, introducing into the VL domain of the parent IgG L37Q and Q45R substitutions or an L46R substitution; or introducing into the VH domain of the parent IgG a substitution selected from E1Q, G17R, R95D, G96A, S102V, P102Y, P102V or S100dM; or introducing into the VH domain of the parent IgG Q1A and P102Y substitutions; Q1E and P102Y substitutions; R95D and S102V substitutions; H94R, R95D, V100F and S102V substitutions; S100dF and P102V substitutions; S100dF and P102Y substitutions; S100dM and P102Y substitutions; S100dM and P102V substitutions; or introducing L37Q and Q45R substitutions into the VL domain of the parent IgG and an R95D or an S102V substitution into the VH domain of the parent IgG, introducing L37Q and Q45R substitutions into the VL domain of the parent IgG and an R95D and an S102V substitution into the VH domain of the parent IgG, or introducing a L46R substitution into the VL domain of the parent IgG and an H94R and an R95D substitution into the VH domain of the parent IgG, said positions in the VH domain and VL domain of the parent immunoglobulin being numbered according to the Kabat numbering scheme; and testing the ability of the immunoglobulin to bind to the target antigen of the parent immunoglobulin thereby producing a variant immunoglobulin having a VL domain and a VH domain which displays both reduced aggregation propensity and increased productivity, wherein said increased productivity is an increase in titre relative to the parent immunoglobulin upon expression in a mammalian system, and said reduced aggregation propensity is a reduction in the proportion of molecules which are aggregated relative to the parent immunoglobulin upon expression in a mammalian system, and wherein the immunoglobulin is a whole antibody or an Fab antibody fragment,
A smokeless barbecue grill, comprising a base and a case placed above the base, wherein the case comprises a hollow structure and a bracket being arranged above the case, wherein the bracket contains a charcoal tray; wherein one or more fans are arranged on the base; the fan for the barbecue grill being provided with one or more air ducts, wherein said one or more air ducts are tilted and bended and form an included angle with a longitudinal direction of the barbecue grill, characterized in that an ignition pan is arranged between the bracket and the charcoal tray, the fan being arranged laterally below the ignition pan and being connected to a sidewall of the ignition pan through the tilted air ducts, wherein an airflow is generated by the fan enters the ignition pan through the air ducts and forms rotational airflow within the ignition pan, that a plurality of air inlets (3.1) of the bracket are arranged in corresponding ones of the air ducts, wherein a bearing part (3.2) is arranged on the bracket, wherein the charcoal tray is arranged on the bearing part (3.2) of the bracket, and the ignition pan is arranged between a bottom of the charcoal tray and a bottom of the bracket, and that the bottom of the charcoal tray corresponding the ignition pan is arranged with a plurality of air vents (4.1), the air vents (4.1) are distributed in a spiral shape, wherein a rotational convex part (4.2) is arranged at the bottom of the charcoal tray along the direction of rotational airflow and is arranged in an inclined water drop shape with a small end and a big end, wherein in a cross-sectional view the rotational convex part (4.2) is low on the small end and high on the big end, such that a convex height of one end is lower than a convex height of another end; wherein a part of the plural air vents (4.1) are arranged on the rotational convex part (4.2).
A method for the supply, staging, handling, and/or exchange of rolls (12, 20) with flat material and/or film material wound thereonto and serving as packaging material for the packaging of piece goods, packs, or the like sets of articles, in which method at least approximately completely unwound and/or depleted rolls are removed from at least one installation position (EB1, EB2) of a packaging machine, and hereupon a new roll / new rolls with flat material and/or film material is/are in each instance mounted into the particular installation position (EB1, EB2), wherein new rolls are staged in a specified feed to the packaging machine, and characterised in that a new roll is mounted into the particular installation position (EB1, EB2) by at least one gripping device and/or handling device after a used-up roll has been previously removed from there by the at least one gripping device and/or handling device, and wherein at least the positions of the rolls in the area of the specified feed and/or of the staging, and the gripping device and/or handling device, and its range of movement are detected by means of room monitoring devices, and at least the movements of the gripping device and/or handling device are controlled in the area of the specified feed and/or of the staging for the rolls based on the detected room data, movement data, and/or sensor data.
A distributed spectrum analyzer, at least comprising a host and one or more radio frequency receivers: the radio frequency receivers being configured to receive a radio frequency signal, characterized in that the radio frequency receivers are configured to perform frequency conversion processing and Analog to Digital AD conversion on the radio frequency signal, and send an AD-converted digital signal to the host by a digital optical module through an optical fiber; the host includes a digital signal processing module and one or more digital optical modules, each of the digital optical modules being configured to connect to one of the radio frequency receivers through the optical fiber and receive the AD-converted digital signal sent by the radio frequency receivers, and the digital signal processing module being configured to process the received AD-converted digital signal. the radio frequency receivers being configured to receive a radio frequency signal, characterized in that the radio frequency receivers are configured to perform frequency conversion processing and Analog to Digital AD conversion on the radio frequency signal, and send an AD-converted digital signal to the host by a digital optical module through an optical fiber; the host includes a digital signal processing module and one or more digital optical modules, each of the digital optical modules being configured to connect to one of the radio frequency receivers through the optical fiber and receive the AD-converted digital signal sent by the radio frequency receivers, and the digital signal processing module being configured to process the received AD-converted digital signal.
A polycarbonate composition, comprising the following components in parts by weight: a. 35-75 parts of the polycarbonate; b. 8-35 parts of the graft copolymer; c. 5-25 parts of the fire retardant; and d. 0-10 parts of other aids; wherein a sum of parts by weight of the four components a, b, c, and d is 100; a total compounding amount of a transition element and an alkaline earth metal based on a total weight of the polycarbonate composition is greater than or equal to 10 ppm and less than or equal to 600 ppm, wherein the content of the transition metal and the content of the alkaline earth metal are measured as indicated in the description, and a compounding molar ratio of the transition element to the alkaline earth metal is 0.1-1. a. 35-75 parts of the polycarbonate; b. 8-35 parts of the graft copolymer; c. 5-25 parts of the fire retardant; and d. 0-10 parts of other aids;
A method of operating a central coordination server for a shared communication medium, comprising: partitioning the shared communication medium into a contention-free partition where the shared communication medium is reserved for first devices associated with a first set of operators and a contention-based partition where second devices associated with a second set of operators contend for access to the shared communication medium in accordance with an Over-the-Air, OTA, coexistence mechanism, at least one operator belonging to both the first and second sets of operators, wherein the contention-free partition being separated from the contention-based partition by a guard band; and notifying the first and second devices of the partitioning, wherein the contention-free partition and the contention-based partition each correspond at least in part to an unlicensed communication medium. partitioning the shared communication medium into a contention-free partition where the shared communication medium is reserved for first devices associated with a first set of operators and a contention-based partition where second devices associated with a second set of operators contend for access to the shared communication medium in accordance with an Over-the-Air, OTA, coexistence mechanism, at least one operator belonging to both the first and second sets of operators, wherein the contention-free partition being separated from the contention-based partition by a guard band; and notifying the first and second devices of the partitioning, wherein the contention-free partition and the contention-based partition each correspond at least in part to an unlicensed communication medium.
A shear sealing system (124, 324) of a blowout preventer of a wellbore, the wellbore having a tubular therein, the blowout preventer comprising a housing having a bore and a guideway therethrough, the tubular positionable in the bore, the shear sealing system comprising: at least one carriage (326a,b) slidably positionable in the guideway of the blowout preventer; at least one blade (328a,b) carried by the at least one carriage and movable thereby between a retracted position and an extended position, the at least one blade engageable with the tubular when in the extended position; characterised in that the shear sealing system comprises at least one seal forming a seal about the tubular and with the at least one blade when the at least one blade is in the extended position, the at least one seal comprising at least one seal collar (332a,b) positionable in the housing of the blowout preventer; wherein the at least one carriage comprises a base and side portions having spars extending from a front end of the base, the spars defining a seal pocket therebetween to receive the tubular and engage the seal collars. at least one carriage (326a,b) slidably positionable in the guideway of the blowout preventer; at least one blade (328a,b) carried by the at least one carriage and movable thereby between a retracted position and an extended position, the at least one blade engageable with the tubular when in the extended position; characterised in that the shear sealing system comprises at least one seal forming a seal about the tubular and with the at least one blade when the at least one blade is in the extended position, the at least one seal comprising at least one seal collar (332a,b) positionable in the housing of the blowout preventer; wherein the at least one carriage comprises a base and side portions having spars extending from a front end of the base, the spars defining a seal pocket therebetween to receive the tubular and engage the seal collars.
A magnetically engaged pump comprising a pump housing including a shaft (40, 108) in the housing; a magnetic coupling in the pump housing including a rotatable magnetic drive, a rotatable driven magnet assembly (34, 112) inwardly of the rotatable magnetic drive and a cylindrical canister extending between the rotatable magnetic drive and the rotatable driven magnet assembly (34, 112), the rotatable driven magnet assembly (34, 112) having a concentric cavity; a pump rotor (58, 114) engaged with the rotatable driven magnet assembly (34, 112) and including an axial passage; a carrier (68, 126) including a bore (74, 128) rotatably disposed about the shaft (40, 108), a thrust bushing (88, 90, 144) radially outwardly of the bore (74, 128) on an end of the carrier (68, 126), and at least one plain bushing (82, 84, 136, 140) in the bore (74, 128) bearing on the shaft (40, 108) characterised by the carrier (68, 126) being within the concentric cavity and fitting through the axial passage for removal from the pump with the pump rotor (58, 114) engaged with the rotatable driven magnet assembly (34, 112) and the rotatable driven magnet assembly (34, 112) magnetically engaged with the rotatable magnetic drive.
An outdoor unit comprising: a housing comprising an inlet and an outlet; an outdoor heat exchanger mounted in the housing; a first fan comprising a plurality of first blades arranged in a radial direction; a second fan comprising a plurality of second blades arranged in the radial direction; and a first motor configured to drive the first fan and a second motor configured to drive the second fan, wherein the first motor and the second motor are configured to rotate the first fan and the second fan in different directions, wherein shafts of the first fan and the second fan are arranged on a same straight line, wherein the first fan is arranged between the outdoor heat exchanger and the second fan so that the air drawn via the inlet is ventilated by the first fan and the second fan sequentially, to be discharged via the outlet, characterized in that the first motor and the second motor are arranged in different directions, wherein the shaft direction height of each second blade of the second fan is larger than the shaft direction height of each first blade of the first fan. a housing comprising an inlet and an outlet; an outdoor heat exchanger mounted in the housing; a first fan comprising a plurality of first blades arranged in a radial direction; a second fan comprising a plurality of second blades arranged in the radial direction; and a first motor configured to drive the first fan and a second motor configured to drive the second fan, wherein the first motor and the second motor are configured to rotate the first fan and the second fan in different directions, wherein shafts of the first fan and the second fan are arranged on a same straight line, wherein the first fan is arranged between the outdoor heat exchanger and the second fan so that the air drawn via the inlet is ventilated by the first fan and the second fan sequentially, to be discharged via the outlet, characterized in that the first motor and the second motor are arranged in different directions, wherein the shaft direction height of each second blade of the second fan is larger than the shaft direction height of each first blade of the first fan.
A nuclear fuel core for supporting nuclear fuel assemblies, the fuel core comprising: a longitudinal axis; an upper core plate; a lower core plate; a plurality of vertically elongated channel boxes extending between the upper and lower core plates (125, 126),; a cylindrical reflector circumferentially surrounding the channel boxes, the upper and lower core plates (125, 126) coupled to opposing ends of the reflector; characterised by each channel box comprising outer walls and inner walls collectively defining a plurality of longitudinally-extending interior cells each having a transverse cross sectional area configured for holding no more than a single nuclear fuel assembly; wherein adjacent cells within each channel box are separated from each other by the inner walls. a longitudinal axis; an upper core plate; a lower core plate; a plurality of vertically elongated channel boxes extending between the upper and lower core plates (125, 126),; a cylindrical reflector circumferentially surrounding the channel boxes, the upper and lower core plates (125, 126) coupled to opposing ends of the reflector; characterised by each channel box comprising outer walls and inner walls collectively defining a plurality of longitudinally-extending interior cells each having a transverse cross sectional area configured for holding no more than a single nuclear fuel assembly; wherein adjacent cells within each channel box are separated from each other by the inner walls.
Aircraft propulsion assembly comprising a pylon with a lower rear fairing, an engine and at least one seal (50 to 56) interposed between a surface of said lower rear fairing and a surface of said engine, the seal comprising several brush seals (64, 64') comprising a plurality of strands made of a heat-resistant material, a first seal comprising a base secured to one of the surfaces (60, 62) and a second seal comprising a base secured to the other of the surfaces (60, 62), the strands of the first brush seal being pressed against the strands of the second brush seal.
A computer-implemented method for processing blockchain data by a blockchain node of a blockchain network in a trusted execution environment, TEE, the computer-implemented method comprising: receiving a request from an application component of the blockchain node to execute one or more software instructions in the TEE; determining one or more blocks stored on the blockchain node required for executing the one or more software instructions, wherein the one or more blocks are stored on the blockchain node and appended to the blockchain network; performing error correction coding of the one or more blocks in the TEE to generate one or more encoded blocks; dividing each of the one or more encoded blocks to a plurality of datasets based on the one or more software instructions; selecting one or more datasets from the plurality of datasets of each of the one or more encoded blocks based on the one or more software instructions; hashing the one or more selected datasets to generate one or more hash values corresponding to the one or more selected datasets; storing the one or more hash values and a remainder of the plurality of datasets not selected from the plurality of datasets to the blockchain node, wherein the datasets corresponding to the hash values are stored on at least one different node of the blockchain network; and instructing the blockchain node to delete a block corresponding to the one or more hash values and the remainder of the plurality of datasets after the one or more hash values and the remainder of the plurality of datasets are stored on the blockchain node. receiving a request from an application component of the blockchain node to execute one or more software instructions in the TEE; determining one or more blocks stored on the blockchain node required for executing the one or more software instructions, wherein the one or more blocks are stored on the blockchain node and appended to the blockchain network; performing error correction coding of the one or more blocks in the TEE to generate one or more encoded blocks; dividing each of the one or more encoded blocks to a plurality of datasets based on the one or more software instructions; selecting one or more datasets from the plurality of datasets of each of the one or more encoded blocks based on the one or more software instructions; hashing the one or more selected datasets to generate one or more hash values corresponding to the one or more selected datasets; storing the one or more hash values and a remainder of the plurality of datasets not selected from the plurality of datasets to the blockchain node, wherein the datasets corresponding to the hash values are stored on at least one different node of the blockchain network; and instructing the blockchain node to delete a block corresponding to the one or more hash values and the remainder of the plurality of datasets after the one or more hash values and the remainder of the plurality of datasets are stored on the blockchain node.
A post Chemical Mechanical Planarization cleaning composition comprising: at least one organic acid or salts thereof selected from the group consisting of dicarboxylic acid, hydroxycarboxylic acid, polycarboxylic acid, salts thereof, and combinations thereof; a fluoride compound selected from the group consisting of hydrofluoric acid, ammonium fluoride, ammonium bifluoride, quaternary ammonium fluoride and combinations thereof; at least one polymeric additive selected from a group consisting of polymer or copolymer comprising ethylene oxide, propylene oxide, or combinations of ethylene oxide and propylene oxide; and combinations thereof; and the polymeric additive has a molecular weight range between 100-1,000,000; a surfactant which is a diphenyl disulfonic acid or its salt having a structure of wherein R is selected from H, or a linear or branched alkyl group with carbon chain length between 1 and 20; and water constituting substantially the remainder of the composition; and optionally corrosion inhibitor; biological preservative; and pH adjusting agent; wherein the composition has a pH of between 1 to 7. at least one organic acid or salts thereof selected from the group consisting of dicarboxylic acid, hydroxycarboxylic acid, polycarboxylic acid, salts thereof, and combinations thereof; a fluoride compound selected from the group consisting of hydrofluoric acid, ammonium fluoride, ammonium bifluoride, quaternary ammonium fluoride and combinations thereof; at least one polymeric additive selected from a group consisting of polymer or copolymer comprising ethylene oxide, propylene oxide, or combinations of ethylene oxide and propylene oxide; and combinations thereof; and the polymeric additive has a molecular weight range between 100-1,000,000; a surfactant which is a diphenyl disulfonic acid or its salt having a structure of wherein R is selected from H, or a linear or branched alkyl group with carbon chain length between 1 and 20; and water constituting substantially the remainder of the composition; and optionally corrosion inhibitor; biological preservative; and pH adjusting agent; wherein the composition has a pH of between 1 to 7.