mhurhangee/ep-ind-claims huggingface dataset:
A method for determining the prognosis of melanoma in a patient with stage IIIB or stage IIIC melanoma, comprising the steps of: (i) determining the expression level of Melanoma Prognostic Markers (MPMs) in a melanoma tumour sample from the patient, the MPMs comprising each of the five markers: milk fat globule-EGF factor 8 protein (MFGE8); isocitrate dehydrogenase 1 (NADP +) soluble; paired immunoglobin-like type 2 receptor alpha (PILRA); major histocompatibility complex, class 1, E (HLA-E); and thioredoxin domain containing 5 (TXNDCS); and (ii) applying a predictive model established by applying a predictive method to expression levels of each of said MPMs in prognostically good and poor tumour samples; and (iii) establishing a prognosis. (i) determining the expression level of Melanoma Prognostic Markers (MPMs) in a melanoma tumour sample from the patient, the MPMs comprising each of the five markers: milk fat globule-EGF factor 8 protein (MFGE8); isocitrate dehydrogenase 1 (NADP +) soluble; paired immunoglobin-like type 2 receptor alpha (PILRA); major histocompatibility complex, class 1, E (HLA-E); and thioredoxin domain containing 5 (TXNDCS); and (ii) applying a predictive model established by applying a predictive method to expression levels of each of said MPMs in prognostically good and poor tumour samples; and (iii) establishing a prognosis.
An image pick-up device comprising: image pick-up means for generating an image picked-up signal (Spa) having a variable image pick-up frame rate (FRp); image signal generation means (114, 115) for generating an output image signal (DVd) from the image picked-up signal (Spa) by adding a number of added frames of the image picked-up signal (Spa) to vary the frame rate of the output image signal (DVd); drive-and-control means for driving and controlling the image signal generation means; wherein the drive-and-control means is configured, when the image pick-up device is set as a slave side image pick-up device, to receive further frame rate information (IFex) comprising the variable image pick-up frame rate (FRp) and the number of added frames and to drive and control the image signal generation means to generate the output image signal (DVd) which is frame-synchronized using the further frame rate information (IFex), and setting information generation means configured, when the image pick-up device is set as a master side image pick-up device, to generate frame rate information comprising the variable image pick-up frame rate (FRp) and the number of added frames for causing generation of a frame-synchronized image signal by a further image pick-up device which is frame-synchronized with the output image signal generated by the image signal generation means; and output means for outputting the frame rate information when the image pick-up device is set as a master side image pick-up device, and for outputting the output image signal generated by the image signal generation means. image pick-up means for generating an image picked-up signal (Spa) having a variable image pick-up frame rate (FRp); image signal generation means (114, 115) for generating an output image signal (DVd) from the image picked-up signal (Spa) by adding a number of added frames of the image picked-up signal (Spa) to vary the frame rate of the output image signal (DVd); drive-and-control means for driving and controlling the image signal generation means; wherein the drive-and-control means is configured, when the image pick-up device is set as a slave side image pick-up device, to receive further frame rate information (IFex) comprising the variable image pick-up frame rate (FRp) and the number of added frames and to drive and control the image signal generation means to generate the output image signal (DVd) which is frame-synchronized using the further frame rate information (IFex), and setting information generation means configured, when the image pick-up device is set as a master side image pick-up device, to generate frame rate information comprising the variable image pick-up frame rate (FRp) and the number of added frames for causing generation of a frame-synchronized image signal by a further image pick-up device which is frame-synchronized with the output image signal generated by the image signal generation means; and output means for outputting the frame rate information when the image pick-up device is set as a master side image pick-up device, and for outputting the output image signal generated by the image signal generation means.
A non-invasive patient interface that is configured to deliver pressurized respiratory gas to the mouth and nares of a patient, the patient interface comprising a cushion module which comprises: (a) a seal for sealing around the mouth and nares of the patient; (b) a housing connected to the seal; (c) an interior volume defined by the seal and the housing; (d) the seal includes a cavity wall located within the interior volume so as to define first and second cavities (1032, 1030) within the interior volume of the cushion module; and (e) a preferential deformation region that is part of the cavity wall and that includes a deformation panel and includes first and second resilient regions (1058, 1060) between which the deformation panel is disposed. (a) a seal for sealing around the mouth and nares of the patient; (b) a housing connected to the seal; (c) an interior volume defined by the seal and the housing; (d) the seal includes a cavity wall located within the interior volume so as to define first and second cavities (1032, 1030) within the interior volume of the cushion module; and (e) a preferential deformation region that is part of the cavity wall and that includes a deformation panel and includes first and second resilient regions (1058, 1060) between which the deformation panel is disposed.
A method of applying a protective coating to a substrate comprises the steps of: providing a turbine engine component substrate formed of a ceramic matrix composite material; forming an environmental barrier coating layer comprising a rare earth disilicate material directly on the substrate; treating an outer surface of the environmental barrier coating layer to form a thermal barrier coating layer comprising a porous rare earth monosilicate material directly on the environmental barrier coating layer, wherein the step of treating the outer surface is performed using a thermal process consisting of the application of heat or a chemical-thermal process consisting of the application of heat and a chemical; and infiltrating at least a portion of the pores with a metal solution or suspension, wherein the metal solution or suspension comprises a metal nano oxide or a metal salt, nitrate, carbonate or oxide. providing a turbine engine component substrate formed of a ceramic matrix composite material; forming an environmental barrier coating layer comprising a rare earth disilicate material directly on the substrate; treating an outer surface of the environmental barrier coating layer to form a thermal barrier coating layer comprising a porous rare earth monosilicate material directly on the environmental barrier coating layer, wherein the step of treating the outer surface is performed using a thermal process consisting of the application of heat or a chemical-thermal process consisting of the application of heat and a chemical; and infiltrating at least a portion of the pores with a metal solution or suspension, wherein the metal solution or suspension comprises a metal nano oxide or a metal salt, nitrate, carbonate or oxide.
Blower unit for a portable, handheld blower apparatus, having a housing section and a tubular receiving space, formed in the housing section, with a first axial end and a second axial end and with a longitudinal center axis, and having an axial blower for generating a blower air flow, the axial blower being driven by a drive motor and the axial blower being arranged in the receiving space of the housing section, and having a central blower hub of the axial blower, said blower hub being aligned with the longitudinal center axis of the receiving space, the receiving space having an intake opening at its first axial end and a discharge opening at its second axial end, characterized in that an air guide plate is arranged at an axial distance (a) in front of the intake opening, the air guide plate has external dimensions that are greater than the external dimensions of the intake opening, and a gap that supplies intake air is formed between the air guide plate and an outer periphery of the housing section. an air guide plate is arranged at an axial distance (a) in front of the intake opening, the air guide plate has external dimensions that are greater than the external dimensions of the intake opening, and a gap that supplies intake air is formed between the air guide plate and an outer periphery of the housing section.
A cache comprising: a p (rows) x q (columns) array of memory units; a row addressing unit; and a column addressing unit; wherein each memory unit has an m (rows) x n (columns) array of memory cells (B0-B15); wherein the column addressing unit has, for each memory unit, m n -to-one multiplexers, one associated with each of the m rows of the memory unit, wherein each n-to-one multiplexer has an input coupled to each of the n memory cells (B0-B15) associated with the row associated with that multiplexer; wherein the row addressing unit has, for each memory unit, n m-to-one multiplexers, one associated with each of the n columns of the memory unit, wherein each m-to-one multiplexer has an input coupled to each of the m memory cells (B0-B15) associated with the column associated with that multiplexer, and wherein the row addressing unit and column addressing unit support reading and/or writing of the array of memory units, such that multiple rows and/or columns of the array of memory units may be read and/or written in parallel. a p (rows) x q (columns) array of memory units; a row addressing unit; and a column addressing unit; wherein each memory unit has an m (rows) x n (columns) array of memory cells (B0-B15); wherein the column addressing unit has, for each memory unit, m n -to-one multiplexers, one associated with each of the m rows of the memory unit, wherein each n-to-one multiplexer has an input coupled to each of the n memory cells (B0-B15) associated with the row associated with that multiplexer; wherein the row addressing unit has, for each memory unit, n m-to-one multiplexers, one associated with each of the n columns of the memory unit, wherein each m-to-one multiplexer has an input coupled to each of the m memory cells (B0-B15) associated with the column associated with that multiplexer, and wherein the row addressing unit and column addressing unit support reading and/or writing of the array of memory units, such that multiple rows and/or columns of the array of memory units may be read and/or written in parallel.
Method for machining a wall of a cylinder of an internal combustion engine, with circumferential grooves being machined into the wall, characterized in that at least one annular saw blade which is provided with a large number of cutting teeth on its circumference is used to make the grooves, the saw blade being moved so as to rotate about its longitudinal axis and being moved on an annular path, the annular path not being circular.
A noise reduction device, comprising: a main tube having a first pass-through area where a fluid enters the main tube; a side-branch connected to the main tube, characterizing in that the main tube comprises a narrowed section having a second pass-through area that is at least 25% smaller than the first pass-through area, the side-branch being connected to the narrowed section of the main tube. a main tube having a first pass-through area where a fluid enters the main tube; a side-branch connected to the main tube,
Frame of a fuselage section of an aircraft that receives external loads comprising a first sector configured specifically to withstand these external loads and a second sector along the remaining perimeter of the fuselage, said first sector comprises the following structural elements: a) a foot piece to be joined to the fuselage skin; b) a head piece; c) a web comprising one or more fitting-pieces (27, 27') for receiving said external loads, and a plurality of X-shaped pieces joined by their ends to said foot piece and said head piece; d) two connecting pieces (39, 39') of the ends of said foot piece and said head piece with the second sector of the frame, characterized in that said fitting pieces (27,27') extend between the foot piece and the head piece. a) a foot piece to be joined to the fuselage skin; b) a head piece; c) a web comprising one or more fitting-pieces (27, 27') for receiving said external loads, and a plurality of X-shaped pieces joined by their ends to said foot piece and said head piece; d) two connecting pieces (39, 39') of the ends of said foot piece and said head piece with the second sector of the frame,
A physical quantity sensor comprising: a movable element that is shaped into a flat plate, has a plurality of openings in a direction passing through a flat plate surface of the flat plate, and is swingable around an axis of rotation; the movable element including a first movable element and a second movable element, a support substrate linked to part of the flat plate surface via a column to support the movable element with a gap between the flat plate surface of the movable element and the support substrate; and a protrusion so provided as to protrude toward the movable element in a region of the support substrate where the protrusion overlaps with the movable element with a gap therebetween when the support substrate is viewed in a direction perpendicular to the flat plate surface, characterised in that, when the support substrate is viewed in the direction perpendicular to the flat plate surface, the openings are provided in a region excluding a D/2-width annular range around an outer circumference of the protrusion, where D represents a maximum outer dimension of the protrusion, wherein the protrusion is provided in a position where a distance between the axis of rotation and the protrusion is smaller than or equal to half of a distance between the axis of rotation and an end of the first movable element in a direction that intersects an axial direction of the axis of rotation. a movable element that is shaped into a flat plate, has a plurality of openings in a direction passing through a flat plate surface of the flat plate, and is swingable around an axis of rotation; the movable element including a first movable element and a second movable element, a support substrate linked to part of the flat plate surface via a column to support the movable element with a gap between the flat plate surface of the movable element and the support substrate; and a protrusion so provided as to protrude toward the movable element in a region of the support substrate where the protrusion overlaps with the movable element with a gap therebetween when the support substrate is viewed in a direction perpendicular to the flat plate surface, characterised in that, when the support substrate is viewed in the direction perpendicular to the flat plate surface, the openings are provided in a region excluding a D/2-width annular range around an outer circumference of the protrusion, where D represents a maximum outer dimension of the protrusion, wherein the protrusion is provided in a position where a distance between the axis of rotation and the protrusion is smaller than or equal to half of a distance between the axis of rotation and an end of the first movable element in a direction that intersects an axial direction of the axis of rotation.
Peptide specifically recognizing a prion protein, consisting in an amino acid sequence selected from a group consisting of: a complementarity determining region according to SEQ ID NO:1, a complementarity determining region according to SEQ ID NO:11, a complementarity determining region according to SEQ ID NO: 12, a complementarity determining region according to SEQ ID NO: 13, and a retro-inverso D-peptide of said CDR according to SEQ ID NO: 2. a complementarity determining region according to SEQ ID NO:1, a complementarity determining region according to SEQ ID NO:11, a complementarity determining region according to SEQ ID NO: 12, a complementarity determining region according to SEQ ID NO: 13, and a retro-inverso D-peptide of said CDR according to SEQ ID NO: 2.
A vaccine comprising: (a) a nucleic acid molecule encoding SEQ ID NO:10; (b) a nucleic acid molecule encoding SEQ ID NO:12; and (c) a nucleic acid molecule encoding SEQ ID NO:4. (a) a nucleic acid molecule encoding SEQ ID NO:10; (b) a nucleic acid molecule encoding SEQ ID NO:12; and (c) a nucleic acid molecule encoding SEQ ID NO:4.
A composition comprising an amorphous, substantially solid film having an average thickness of 0.005 to 5 mm, which is soluble in an aqueous solution, said film comprising a biologically active polypeptide, a sugar and an amphipathic surfactant, wherein the amphipathic surfactant comprises poly(maleic anhydride-alt-1 octadecene), wherein the poly(maleic anhydride-alt-1 octadecene) is substituted with 3-(dimethylamino) propylamine, wherein the composition comprises 0.1% to 10% of said poly(maleic anhydride-alt-1 octadecene), wherein the sugar is selected from group consisting of: glucose, dextrose, fructose, lactose, maltose, xylose, sucrose, corn sugar syrup, sorbitol, hexitol, maltilol, xylitol, mannitol, melezitose, raffinose, and a combination thereof.
Use of a device for adjusting components in steel and metal construction relative to a support or contact surface, the device comprising: A) a clamping member that is fastenable to a component and comprises a clamping sleeve which has an internal thread and a clamping element which has an internal thread; and B) a spacer having a longitudinal axis and a shaft that has an external thread, wherein the external thread of the spacer is engageable with the internal thread of the clamping sleeve, wherein C) the clamping sleeve comprises an external thread and means for contacting a component, the means being disposed in an axial end position and having a radially projecting shoulder; and D) the internal thread of the clamping element is engageable with the external thread of the clamping sleeve so that the component is fixedly clampable between the clamping element and the shoulder of the clamping sleeve, characterized in that E) the external thread of the spacer is provided with a slide coating; and F) means for receiving a tool at the spacer are apt to pass through the internal thread of the clamping sleeve so that the external thread of the spacer is engageable with the internal thread of the clamping sleeve. A) a clamping member that is fastenable to a component and comprises a clamping sleeve which has an internal thread and a clamping element which has an internal thread; and B) a spacer having a longitudinal axis and a shaft that has an external thread, wherein the external thread of the spacer is engageable with the internal thread of the clamping sleeve, wherein C) the clamping sleeve comprises an external thread and means for contacting a component, the means being disposed in an axial end position and having a radially projecting shoulder; and D) the internal thread of the clamping element is engageable with the external thread of the clamping sleeve so that the component is fixedly clampable between the clamping element and the shoulder of the clamping sleeve, characterized in that E) the external thread of the spacer is provided with a slide coating; and F) means for receiving a tool at the spacer are apt to pass through the internal thread of the clamping sleeve so that the external thread of the spacer is engageable with the internal thread of the clamping sleeve.
A method for verifying a data set, stored in a device to be tested, by a testing device by means of a challenge-response method, in which: - the device receives a challenge from a challenge provider or calculates this itself in coordination with the challenge provider, - the device forms a response reply using the challenge and sends the formed response reply and the challenge to the testing device, - the testing device evaluates the sent response reply and thus verifies the data set by the testing device calculating a hash value from the data set and comparing it with a hash value contained in the response reply, and verifies the challenge, wherein: - the challenge provider is designed as an external challenge provider different from the testing device, - the testing device also receives the challenge from a challenge provider or calculates this itself in coordination with the challenge provider, and - the testing device verifies the challenge received from the device by means of the challenge received from the challenge provider or calculated in coordination with the challenge provider, wherein the data set has the function of an electronic ticket for means of transport of a transport system, and wherein the challenge provider comprises one or more challenge provider instances which are provided in one or more or all means of transport, or/and at entrances of these means of transport, or/and in access areas to the transport system. - the device receives a challenge from a challenge provider or calculates this itself in coordination with the challenge provider, - the device forms a response reply using the challenge and sends the formed response reply and the challenge to the testing device, - the testing device evaluates the sent response reply and thus verifies the data set by the testing device calculating a hash value from the data set and comparing it with a hash value contained in the response reply, and verifies the challenge, - the challenge provider is designed as an external challenge provider different from the testing device, - the testing device also receives the challenge from a challenge provider or calculates this itself in coordination with the challenge provider, and - the testing device verifies the challenge received from the device by means of the challenge received from the challenge provider or calculated in coordination with the challenge provider,
A mobile health device comprising: a geolocation coordinate generator for generating geolocation data and corresponding time points, the geolocation data comprising at least latitude and longitude coordinates; a mobile health-based application that receives the geolocation data and corresponding time points from the geolocation coordinate generator; and a processor that uses vector-based calculations stored in the mobile health-based application to transform the geolocation data and corresponding time points into vectors corresponding to intervals between the corresponding received time points, wherein the vectors do not contain any geolocation data, and to determine a patient territory digital biomarker based upon the vectors, wherein the patient territory digital biomarker comprises the area that a patient traverses in a specific period of time. a geolocation coordinate generator for generating geolocation data and corresponding time points, the geolocation data comprising at least latitude and longitude coordinates; a mobile health-based application that receives the geolocation data and corresponding time points from the geolocation coordinate generator; and a processor that uses vector-based calculations stored in the mobile health-based application to transform the geolocation data and corresponding time points into vectors corresponding to intervals between the corresponding received time points, wherein the vectors do not contain any geolocation data, and to determine a patient territory digital biomarker based upon the vectors, wherein the patient territory digital biomarker comprises the area that a patient traverses in a specific period of time.