A motorized suturing device for tissue closure comprising: - a handle having a proximal end and a distal end, the handle defining an enclosable compartment therein, the enclosable compartment being adjustable from an open condition wherein the compartment is exposed to the environment outside the compartment to an enclosed condition wherein the enclosable compartment defines a sterile barrier that isolates the enclosable compartment from the environment outside the compartment; - a pusher assembly extending from the distal end of the handle, the pusher assembly_having a drive arm extending from a drive shaft and a drive mechanism (90,95,96,98) at a distal end of the drive arm, wherein the drive mechanism (90,95,96,98) is capable of releasably engaging and rotating a suturing needle having a pointed end and a blunt end around a circular needle track about a rotational axis, - a cartridge having a protective housing receiving the suturing needle, the cartridge extending from a distal end of a cartridge holder assembly and releasably attached to said cartridge holder assembly, wherein said pusher assembly is rotatably guided within said cartridge holder assembly so that the pointed end of the suturing needle is positioned within the protective housing before and after a complete rotation of the suturing needle about said rotational axis, - a removable electronic module that is removably disposable in the enclosable compartment, the enclosable compartment forming a sterile barrier around the removable electronic module when the handle is in the enclosed condition, the removable electronic module comprising an actuating mechanism (59,61) that mechanically engages the drive shaft via a coupling (73,80,84;63,67,67a) to rotate the drive shaft and the drive mechanism (90,95,96,98), thereby rotating the suturing needle about the rotational axis, the removable electronic module including: (i) a power source for providing power to the electronic module; (ii) a motor and a gear box adapted to provide rotational force to rotate the drive shaft and the drive mechanism to rotate the suturing needle; and (iii) an electronics board that controls operation of the electronic module, wherein said coupling (73, 80, 84; 63, 67, 67a) is arranged and configured so as to releasably engage said electronic module in axial alignment of the rotational axis of the drive arm of the pusher assembly. - a handle having a proximal end and a distal end, the handle defining an enclosable compartment therein, the enclosable compartment being adjustable from an open condition wherein the compartment is exposed to the environment outside the compartment to an enclosed condition wherein the enclosable compartment defines a sterile barrier that isolates the enclosable compartment from the environment outside the compartment; - a pusher assembly extending from the distal end of the handle, the pusher assembly_having a drive arm extending from a drive shaft and a drive mechanism (90,95,96,98) at a distal end of the drive arm, wherein the drive mechanism (90,95,96,98) is capable of releasably engaging and rotating a suturing needle having a pointed end and a blunt end around a circular needle track about a rotational axis, - a cartridge having a protective housing receiving the suturing needle, the cartridge extending from a distal end of a cartridge holder assembly and releasably attached to said cartridge holder assembly, wherein said pusher assembly is rotatably guided within said cartridge holder assembly so that the pointed end of the suturing needle is positioned within the protective housing before and after a complete rotation of the suturing needle about said rotational axis, - a removable electronic module that is removably disposable in the enclosable compartment, the enclosable compartment forming a sterile barrier around the removable electronic module when the handle is in the enclosed condition, the removable electronic module comprising an actuating mechanism (59,61) that mechanically engages the drive shaft via a coupling (73,80,84;63,67,67a) to rotate the drive shaft and the drive mechanism (90,95,96,98), thereby rotating the suturing needle about the rotational axis, the removable electronic module including: (i) a power source for providing power to the electronic module; (ii) a motor and a gear box adapted to provide rotational force to rotate the drive shaft and the drive mechanism to rotate the suturing needle; and (iii) an electronics board that controls operation of the electronic module, wherein said coupling (73, 80, 84; 63, 67, 67a) is arranged and configured so as to releasably engage said electronic module in axial alignment of the rotational axis of the drive arm of the pusher assembly. (i) a power source for providing power to the electronic module; (ii) a motor and a gear box adapted to provide rotational force to rotate the drive shaft and the drive mechanism to rotate the suturing needle; and (iii) an electronics board that controls operation of the electronic module,