A system including a touch sense circuit and a capacitive touch panel, the touch sense circuit configured to supply charge to touch electrodes of the touch panel and generate a touch sense signal (Voutp) at the touch electrodes of the touch panel in response to a touch drive signal (V M) having a first period in which the touch drive signal (V M) is at a first level and a second period in which the touch drive signal (V M) is at a second level; the touch sense circuit comprising an integrator including: a first sampling circuit configured to sample the touch sense signal (Voutp) during a first period of the touch drive signal in which the touch drive signal (V M) is at the first level, to generate a first sampled signal, the first sampled signal being indicative of a first difference between the touch sense signal (Voutp) and a first reference voltage (VREFI1); a second sampling circuit configured to sample the touch sense signal (Voutp) during a second period of the touch drive signal in which the touch drive signal (V M) is at the second level, to generate a second sampled signal, the second sampled signal being indicative of a second difference between the touch sense signal (Voutp) and a second reference voltage (VREFI2), the second sampling circuit configured to generate the second sampled signal in a same polarity as the first sampled signal; and a single-ended amplifier including an input terminal and an output terminal, both the first sampled signal and the second sampled signal being input to the input terminal of the single-ended amplifier of the integrator and integrated to generate an output signal at the output terminal of the single-ended amplifier of the integrator, the output signal being used to detect a touch input; the touch sense circuit further configured to set the first reference voltage (VREFI1) and the second reference voltage (VREFI2) to a value of the touch sense signal during the first period and the second period, respectively, of the touch drive signal when there is no touch. a first sampling circuit configured to sample the touch sense signal (Voutp) during a first period of the touch drive signal in which the touch drive signal (V M) is at the first level, to generate a first sampled signal, the first sampled signal being indicative of a first difference between the touch sense signal (Voutp) and a first reference voltage (VREFI1); a second sampling circuit configured to sample the touch sense signal (Voutp) during a second period of the touch drive signal in which the touch drive signal (V M) is at the second level, to generate a second sampled signal, the second sampled signal being indicative of a second difference between the touch sense signal (Voutp) and a second reference voltage (VREFI2), the second sampling circuit configured to generate the second sampled signal in a same polarity as the first sampled signal; and a single-ended amplifier including an input terminal and an output terminal, both the first sampled signal and the second sampled signal being input to the input terminal of the single-ended amplifier of the integrator and integrated to generate an output signal at the output terminal of the single-ended amplifier of the integrator, the output signal being used to detect a touch input; the touch sense circuit further configured to set the first reference voltage (VREFI1) and the second reference voltage (VREFI2) to a value of the touch sense signal during the first period and the second period, respectively, of the touch drive signal when there is no touch.