A device adapted for creating a sealed connection at an opening in a wall of a heart, comprising: a conduit having an end and a central axis in an axial direction for fluid to flow therethrough; a sleeve; a seal member attached to a first end of the sleeve, the seal member having a ribbed surface facing a second end of the sleeve, the sleeve being engaged with the conduit, the seal member configured for moving between a folded position, wherein the ribbed surface is configured to be folded so as to pass through the opening of the wall of the heart, and radially away from the central axis to an open position wherein the seal member is configured to be expanded so that the seal member has a cross-dimension that is larger than a cross-dimension of the opening in the wall of the heart with the ribbed surface configured to face the inner wall of the heart and to be positioned around the opening of the wall of the heart; an introducer configured to be secured for movement between the first and second positions relative to the conduit, in the first position, the introducer configured for maintaining the seal member in the folded position to allow for insertion of the seal member through the opening in the wall of the heart and, in the second position, the introducer configured for allowing for expansion of the seal member so that the seal member has a cross-dimension that is larger than a cross-dimension of the opening in the wall of the heart, the introducer having at least one segment at an angle relative to the central axis; a clamp component adapted to be positioned outside of the heart, wherein the clamp component has an epicardial seal piece having an inner and outer diameter adapted to engage the wall of the heart, a flange attached to the epicardial seal piece and a mounting piece attached to the flange; and a locking mechanism, characterized in that the locking mechanism has a lock body that is attached to the mounting piece and radially movable in a radial direction from a position distant from the central axis to a position closer to the central axis, and means for moving the lock body in the radial direction, wherein the lock body engages an angled top surface of the intermediate segments to produce an axial force on the flange, wherein said radial movement of the lock body creates an axial force on the clamp component, the clamp component being configured to produce a clamping force in the axial direction with the wall of the heart between the clamp component and the seal member so that a seal is created between the ribbed surface of the seal member and an inner wall of the heart. a conduit having an end and a central axis in an axial direction for fluid to flow therethrough; a sleeve; a seal member attached to a first end of the sleeve, the seal member having a ribbed surface facing a second end of the sleeve, the sleeve being engaged with the conduit, the seal member configured for moving between a folded position, wherein the ribbed surface is configured to be folded so as to pass through the opening of the wall of the heart, and radially away from the central axis to an open position wherein the seal member is configured to be expanded so that the seal member has a cross-dimension that is larger than a cross-dimension of the opening in the wall of the heart with the ribbed surface configured to face the inner wall of the heart and to be positioned around the opening of the wall of the heart; an introducer configured to be secured for movement between the first and second positions relative to the conduit, in the first position, the introducer configured for maintaining the seal member in the folded position to allow for insertion of the seal member through the opening in the wall of the heart and, in the second position, the introducer configured for allowing for expansion of the seal member so that the seal member has a cross-dimension that is larger than a cross-dimension of the opening in the wall of the heart, the introducer having at least one segment at an angle relative to the central axis; a clamp component adapted to be positioned outside of the heart, wherein the clamp component has an epicardial seal piece having an inner and outer diameter adapted to engage the wall of the heart, a flange attached to the epicardial seal piece and a mounting piece attached to the flange; and a locking mechanism,