A compound of Formula, or a pharmaceutically acceptable salt thereof, wherein: Q is -CO 2 R; R is hydrogen or C 1 -C 8 alkyl; G is -X-Y; X is -C 1 alkylene; Y is optionally substituted indanyl, optionally substituted tetralinyl, optionally substituted tetrahydroquinolinyl, optionally substituted naphthyl, optionally substituted indolyl, optionally substituted benzofuranyl, optionally substituted 2,3-dihydrobenzofuranyl, optionally substituted 2,3-dihydrobenzo[ b][1,4] dioxinyl, or optionally substituted adamantyl, wherein each of indanyl, tetralinyl, tetrahydroquinolinyl, naphthyl, indolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzo[ b][1,4]dioxinyl and adamantyl is optionally substituted by one or more substituents independently selected from: C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, halo, fluoroalkyl, nitro, aralkenyl, aralkynyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, cyano, -R b -OR a, -R b -OC -R a, -R b -OC -OR a, -R b -OC -N(R a) 2, -R b -N(R a) 2, -R b -C R a, -R b -C OR a, -R b -O-R c -C N(R a) 2, -R b -N(R a)C OR a, -R b -N(R a)S t R a, -R b -S t OR a, -R b -S t OR a, or -R b -S t N(R a) 2; wherein: each R a is independently hydrogen, C 1 -C 3 alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl; each R b is independently a direct bond or a straight or branched alkylene or alkenylene chain; each R c is a straight or branched alkylene or alkenylene chain; and t is 1 or 2. Q is -CO 2 R; R is hydrogen or C 1 -C 8 alkyl; G is -X-Y; X is -C 1 alkylene; Y is optionally substituted indanyl, optionally substituted tetralinyl, optionally substituted tetrahydroquinolinyl, optionally substituted naphthyl, optionally substituted indolyl, optionally substituted benzofuranyl, optionally substituted 2,3-dihydrobenzofuranyl, optionally substituted 2,3-dihydrobenzo[ b][1,4] dioxinyl, or optionally substituted adamantyl, wherein each of indanyl, tetralinyl, tetrahydroquinolinyl, naphthyl, indolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzo[ b][1,4]dioxinyl and adamantyl is optionally substituted by one or more substituents independently selected from: C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, halo, fluoroalkyl, nitro, aralkenyl, aralkynyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, cyano, -R b -OR a, -R b -OC -R a, -R b -OC -OR a, -R b -OC -N(R a) 2, -R b -N(R a) 2, -R b -C R a, -R b -C OR a, -R b -O-R c -C N(R a) 2, -R b -N(R a)C OR a, -R b -N(R a)S t R a, -R b -S t OR a, -R b -S t OR a, or -R b -S t N(R a) 2; wherein: each R a is independently hydrogen, C 1 -C 3 alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl; each R b is independently a direct bond or a straight or branched alkylene or alkenylene chain; each R c is a straight or branched alkylene or alkenylene chain; and t is 1 or 2. X is -C 1 alkylene; Y is optionally substituted indanyl, optionally substituted tetralinyl, optionally substituted tetrahydroquinolinyl, optionally substituted naphthyl, optionally substituted indolyl, optionally substituted benzofuranyl, optionally substituted 2,3-dihydrobenzofuranyl, optionally substituted 2,3-dihydrobenzo[ b][1,4] dioxinyl, or optionally substituted adamantyl, wherein each of indanyl, tetralinyl, tetrahydroquinolinyl, naphthyl, indolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzo[ b][1,4]dioxinyl and adamantyl is optionally substituted by one or more substituents independently selected from: C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, halo, fluoroalkyl, nitro, aralkenyl, aralkynyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, cyano, -R b -OR a, -R b -OC -R a, -R b -OC -OR a, -R b -OC -N(R a) 2, -R b -N(R a) 2, -R b -C R a, -R b -C OR a, -R b -O-R c -C N(R a) 2, -R b -N(R a)C OR a, -R b -N(R a)S t R a, -R b -S t OR a, -R b -S t OR a, or -R b -S t N(R a) 2; wherein: each R a is independently hydrogen, C 1 -C 3 alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl; each R b is independently a direct bond or a straight or branched alkylene or alkenylene chain; each R c is a straight or branched alkylene or alkenylene chain; and t is 1 or 2. C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, halo, fluoroalkyl, nitro, aralkenyl, aralkynyl, carbocyclyl, carbocyclylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, cyano, -R b -OR a, -R b -OC -R a, -R b -OC -OR a, -R b -OC -N(R a) 2, -R b -N(R a) 2, -R b -C R a, -R b -C OR a, -R b -O-R c -C N(R a) 2, -R b -N(R a)C OR a, -R b -N(R a)S t R a, -R b -S t OR a, -R b -S t OR a, or -R b -S t N(R a) 2; wherein: each R a is independently hydrogen, C 1 -C 3 alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl; each R b is independently a direct bond or a straight or branched alkylene or alkenylene chain; each R c is a straight or branched alkylene or alkenylene chain; and t is 1 or 2. each R a is independently hydrogen, C 1 -C 3 alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl; each R b is independently a direct bond or a straight or branched alkylene or alkenylene chain; each R c is a straight or branched alkylene or alkenylene chain; and t is 1 or 2.