The compound selected from a) the Compound of Formula II-A or II-B: is wherein (i) Q is C(=O), C(=S), or CH 2; (ii) L is a single bond, -N -, -S-, (iii) R 1 is H or C 1-4 alkyl; (iv) R 2 is H and R 3 and R 4 together form a di-, tri- or tetramethylene bridge; (v) R 5 is a) -D-E-F, wherein: D is C 1-4 alkylene; E is arylene or heteroarylene; F is aryl, heteroaryl, C 3-7 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O; wherein D, E and F are independently and optionally substituted with one or more halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy, or an additional aryl or heteroaryl; or b) attached to the nitrogen on the pyrrolo portion of Formula II-A or II-B and is a moiety of Formula A wherein X, Y and Z are, independently, N or C, and R 8, R 9, R 11 and R 12 are independently H or halogen, and R 10 is C 1-4 alkoxy, provided that when X, Y, or Z is nitrogen, R 8, R 9, or R 10, respectively, is not present; (vi) R 6 is H, aryl, wherein the aryl is optionally substituted with one or more C 1-4 alkyl, halogen, haloC 1-4 alkyl, hydroxy, carboxy, or an additional aryl, heteroaryl or C 3-8 cycloalkyl; (vii) R 7 is H, C 1-6 alkyl; (viii) n = 0 or 1; (ix) when n=1, A is -C(R 13 R 41)-, wherein R 13 and R 14, are, independently, H or C 1-4 alkyl, in free or salt form. a) the Compound of Formula II-A or II-B: is wherein (i) Q is C(=O), C(=S), or CH 2; (ii) L is a single bond, -N -, -S-, (iii) R 1 is H or C 1-4 alkyl; (iv) R 2 is H and R 3 and R 4 together form a di-, tri- or tetramethylene bridge; (v) R 5 is a) -D-E-F, wherein: D is C 1-4 alkylene; E is arylene or heteroarylene; F is aryl, heteroaryl, C 3-7 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O; wherein D, E and F are independently and optionally substituted with one or more halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy, or an additional aryl or heteroaryl; or b) attached to the nitrogen on the pyrrolo portion of Formula II-A or II-B and is a moiety of Formula A wherein X, Y and Z are, independently, N or C, and R 8, R 9, R 11 and R 12 are independently H or halogen, and R 10 is C 1-4 alkoxy, provided that when X, Y, or Z is nitrogen, R 8, R 9, or R 10, respectively, is not present; (vi) R 6 is H, aryl, wherein the aryl is optionally substituted with one or more C 1-4 alkyl, halogen, haloC 1-4 alkyl, hydroxy, carboxy, or an additional aryl, heteroaryl or C 3-8 cycloalkyl; (vii) R 7 is H, C 1-6 alkyl; (viii) n = 0 or 1; (ix) when n=1, A is -C(R 13 R 41)-, wherein R 13 and R 14, are, independently, H or C 1-4 alkyl, in free or salt form. (i) Q is C(=O), C(=S), or CH 2; (ii) L is a single bond, -N -, -S-, (iii) R 1 is H or C 1-4 alkyl; (iv) R 2 is H and R 3 and R 4 together form a di-, tri- or tetramethylene bridge; (v) R 5 is a) -D-E-F, wherein: D is C 1-4 alkylene; E is arylene or heteroarylene; F is aryl, heteroaryl, C 3-7 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O; wherein D, E and F are independently and optionally substituted with one or more halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy, or an additional aryl or heteroaryl; or b) attached to the nitrogen on the pyrrolo portion of Formula II-A or II-B and is a moiety of Formula A wherein X, Y and Z are, independently, N or C, and R 8, R 9, R 11 and R 12 are independently H or halogen, and R 10 is C 1-4 alkoxy, provided that when X, Y, or Z is nitrogen, R 8, R 9, or R 10, respectively, is not present; a) -D-E-F, wherein: D is C 1-4 alkylene; E is arylene or heteroarylene; F is aryl, heteroaryl, C 3-7 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O; wherein D, E and F are independently and optionally substituted with one or more halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy, or an additional aryl or heteroaryl; or D is C 1-4 alkylene; E is arylene or heteroarylene; F is aryl, heteroaryl, C 3-7 cycloalkyl optionally containing at least one atom selected from a group consisting of N or O; wherein D, E and F are independently and optionally substituted with one or more halo, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, hydroxy, carboxy, or an additional aryl or heteroaryl; or b) attached to the nitrogen on the pyrrolo portion of Formula II-A or II-B and is a moiety of Formula A wherein X, Y and Z are, independently, N or C, and R 8, R 9, R 11 and R 12 are independently H or halogen, and R 10 is C 1-4 alkoxy, provided that when X, Y, or Z is nitrogen, R 8, R 9, or R 10, respectively, is not present; (vi) R 6 is H, aryl, wherein the aryl is optionally substituted with one or more C 1-4 alkyl, halogen, haloC 1-4 alkyl, hydroxy, carboxy, or an additional aryl, heteroaryl or C 3-8 cycloalkyl; (vii) R 7 is H, C 1-6 alkyl; (viii) n = 0 or 1; (ix) when n=1, A is -C(R 13 R 41)-, wherein R 13 and R 14, are, independently, H or C 1-4 alkyl, in free or salt form.