A lipstick case comprising: a lipstick holder loaded with a lipstick; a rotation body including a fixing body disposed at a lower portion of the lipstick holder and protrusively formed from a center portion of a lower end thereof to an upper direction so as to fix the lipstick holder, and a first screw thread formed at an inner circumferential surface thereof; an ascending and descending member including a second screw thread coupled in a screw coupling with the first screw thread at an outer circumferential surface thereof so as to be rotated by a rotation of the rotation body, wherein the ascending and descending member receives the lipstick when ascending, and exposes the lipstick to the outside when descending; an ascending and descending guide member rotatably coupled with the rotation body, and comprising a rotation preventing means which prevents the ascending and descending member from being rotated when the rotation body rotates, and guides a vertical movement of the ascending and descending member; and a cover part encasing the lipstick and detachably coupled to the ascending and descending guide member, the ascending and descending member comprising a guide tube wherein the fixing body is inserted and the second screw thread is formed at an outer circumferential surface thereof; and a lipstick receiving tube which is extended from the guide tube to an upper portion thereof and receives the lipstick, wherein the rotation preventing means comprises a rotation guiding part which is disposed at an upper portion of the ascending and descending guide member and has a square shape with all corners rounded so as to prevent a rotation of the lipstick receiving tube, wherein the lipstick receiving tube is configured to have a shape which corresponds to the shape of the rotation guiding part. a lipstick holder loaded with a lipstick; a rotation body including a fixing body disposed at a lower portion of the lipstick holder and protrusively formed from a center portion of a lower end thereof to an upper direction so as to fix the lipstick holder, and a first screw thread formed at an inner circumferential surface thereof; an ascending and descending member including a second screw thread coupled in a screw coupling with the first screw thread at an outer circumferential surface thereof so as to be rotated by a rotation of the rotation body, wherein the ascending and descending member receives the lipstick when ascending, and exposes the lipstick to the outside when descending; an ascending and descending guide member rotatably coupled with the rotation body, and comprising a rotation preventing means which prevents the ascending and descending member from being rotated when the rotation body rotates, and guides a vertical movement of the ascending and descending member; and a cover part encasing the lipstick and detachably coupled to the ascending and descending guide member, the ascending and descending member comprising a guide tube wherein the fixing body is inserted and the second screw thread is formed at an outer circumferential surface thereof; and a lipstick receiving tube which is extended from the guide tube to an upper portion thereof and receives the lipstick, wherein the rotation preventing means comprises a rotation guiding part which is disposed at an upper portion of the ascending and descending guide member and has a square shape with all corners rounded so as to prevent a rotation of the lipstick receiving tube, wherein the lipstick receiving tube is configured to have a shape which corresponds to the shape of the rotation guiding part.