A compound having Formula: or a stereoisomer, a tautomer, an N -oxide, a solvate, or a pharmaceutically acceptable salt thereof, wherein: Q is H, OR a, NR a R b, -C(=O)NR a R b, -N(R c)C(=O)R d, -N(R c)C(=O)OR a or -N(R c)C(=O)NR a R b; U is CR 7 or N; X is C 6 -C 10, aryl or 5-10 membered heteroaryl, wherein each of the C 6 -C 10 aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from F, Cl, Br, CN, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OR a, NR a R b, -(C 1 -C 4 alkylene)-OR a and -(C 1 -C 4 alkylene)-NR a R b; each Y is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, -(C 1 -C 4 alkylene)-(C 3 -C 8 cycloalkyl), 3-8 membered heterocyclyl, -(C 1 -C 4 alkylene)-(3-8 membered heterocyclyl), C 6 -C 10 aryl, -(C 1 -C 4 alkylene)-(C 6 -C 10 aryl), 5-10 membered heteroaryl, -(C 1 -C 4 alkylene)-(5-10 membered heteroaryl), OR a, NR a R b, -(C 1 -C 4 alkylene)-OR a or -(C 1 -C 4 alkylene)-NR a R b; m is 0, 1, 2, 3, 4; W is -(CH 2) n -, -(CH 2) n O-, -(CH 2) n NH- or -(CH 2) n S-, wherein n is 0, 1, 2, 3 or 4; each of R 1, R 2, R 3, R 4, R 5, R 6 and R 7 is independently H, F, Cl, Br, CN, N 3, OR a, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; each of R a, R b and R c is independently H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 3 -C 6 cycloalkyl, wherein each of the C 1 -C 6 alkyl, C 1 -C 6 haloalkyl and C 3 -C 6 cycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, CN, N 3, OH, NH 2, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkylamino; and R d is H, C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl, wherein each of the C 1 -C 6 alkyl and C 3 -C 8 cycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, Br, CN, OR a, NR a R b, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -(C 1 -C 4 alkylene)-OR a and -(C 1 -C 4 alkylene)-NR a R b. Q is H, OR a, NR a R b, -C(=O)NR a R b, -N(R c)C(=O)R d, -N(R c)C(=O)OR a or -N(R c)C(=O)NR a R b; U is CR 7 or N; X is C 6 -C 10, aryl or 5-10 membered heteroaryl, wherein each of the C 6 -C 10 aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from F, Cl, Br, CN, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, OR a, NR a R b, -(C 1 -C 4 alkylene)-OR a and -(C 1 -C 4 alkylene)-NR a R b; each Y is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, -(C 1 -C 4 alkylene)-(C 3 -C 8 cycloalkyl), 3-8 membered heterocyclyl, -(C 1 -C 4 alkylene)-(3-8 membered heterocyclyl), C 6 -C 10 aryl, -(C 1 -C 4 alkylene)-(C 6 -C 10 aryl), 5-10 membered heteroaryl, -(C 1 -C 4 alkylene)-(5-10 membered heteroaryl), OR a, NR a R b, -(C 1 -C 4 alkylene)-OR a or -(C 1 -C 4 alkylene)-NR a R b; m is 0, 1, 2, 3, 4; W is -(CH 2) n -, -(CH 2) n O-, -(CH 2) n NH- or -(CH 2) n S-, wherein n is 0, 1, 2, 3 or 4; each of R 1, R 2, R 3, R 4, R 5, R 6 and R 7 is independently H, F, Cl, Br, CN, N 3, OR a, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; each of R a, R b and R c is independently H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 3 -C 6 cycloalkyl, wherein each of the C 1 -C 6 alkyl, C 1 -C 6 haloalkyl and C 3 -C 6 cycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, CN, N 3, OH, NH 2, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy and C 1 -C 6 alkylamino; and R d is H, C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl, wherein each of the C 1 -C 6 alkyl and C 3 -C 8 cycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, Br, CN, OR a, NR a R b, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -(C 1 -C 4 alkylene)-OR a and -(C 1 -C 4 alkylene)-NR a R b.