A compound having a structural formula: wherein A is selected from the group consisting of wherein R 1 and R 2, independently, are selected from the group consisting of H, CN, NO 2, halo, alkyl, cycloalkyl, alkenyl, cycloalkenyl; alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', SR', NR'R", COR', CO 2 R', OCOR', CONR'R", CONR'SO 2 R", NR'COR", NR'CONR"R"', NR'C=SNR"R"', NR'SO 2 R", SO 2 R', and SO 2 NR'R"; R 3 is selected from a group consisting; of H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', NR'R", CO 2 R', COR', CONR'R", CONR'SO 2 R", C 1-3 alkyleneCH CH 2 OH, SO 2 R', and SO 2 NR'R"; R', R", and R"', independently, are H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, CF 3, aryl, heteroaryl, C 1-3 alkyleneheterocycloalkyl, or heterocycloalkyl; R' and R", or R" and R"', can be taken together with the atom to which they are bound to form a 3 to 7 membered ring; B,C, D, and E individually are optionally substituted phenyl, wherein the phenyl contains one to four substituents independently selected from the group consisting of CN, NO 2, halo, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', SR', NR'R", CO 2 R', COR', OCOR', CONR'R", CONR'SO 2 R", NR'COR", NR'SO 2 R", C 1-3 alkyleneCH CH 2 OH, SO 2 R', and SO 2 NR'R", wherein each R' and R", independently, is H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, CF 3, aryl, heteroaryl, C 1-3 alkyleneheterocycloalkyl, or heterocycloalkyl; and X and Y are selected from the group consisting of -C≡C-, -CH 2 -CH 2 -, -NH-CH 2 -CH 2 -NH-, or a pharmaceutically acceptable salt thereof. wherein R 1 and R 2, independently, are selected from the group consisting of H, CN, NO 2, halo, alkyl, cycloalkyl, alkenyl, cycloalkenyl; alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', SR', NR'R", COR', CO 2 R', OCOR', CONR'R", CONR'SO 2 R", NR'COR", NR'CONR"R"', NR'C=SNR"R"', NR'SO 2 R", SO 2 R', and SO 2 NR'R"; R 3 is selected from a group consisting; of H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', NR'R", CO 2 R', COR', CONR'R", CONR'SO 2 R", C 1-3 alkyleneCH CH 2 OH, SO 2 R', and SO 2 NR'R"; R', R", and R"', independently, are H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, CF 3, aryl, heteroaryl, C 1-3 alkyleneheterocycloalkyl, or heterocycloalkyl; R' and R", or R" and R"', can be taken together with the atom to which they are bound to form a 3 to 7 membered ring; B,C, D, and E individually are optionally substituted phenyl, wherein the phenyl contains one to four substituents independently selected from the group consisting of CN, NO 2, halo, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, OR', SR', NR'R", CO 2 R', COR', OCOR', CONR'R", CONR'SO 2 R", NR'COR", NR'SO 2 R", C 1-3 alkyleneCH CH 2 OH, SO 2 R', and SO 2 NR'R", wherein each R' and R", independently, is H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, CF 3, aryl, heteroaryl, C 1-3 alkyleneheterocycloalkyl, or heterocycloalkyl; and X and Y are selected from the group consisting of -C≡C-, -CH 2 -CH 2 -, -NH-CH 2 -CH 2 -NH-, or a pharmaceutically acceptable salt thereof.