mhurhangee/ep-ind-claims huggingface dataset:
A method for determining a subject's responsiveness to a multi-kinase inhibitor comprising measuring the expression profile of a panel of gene markers in a biological sample from the subject, wherein the panel of gene markers consists of one or more markers selected from the group consisting of SEC14L2, H6PD, TMEM140, SLC2A5, ACTA1, IRF8, STAT2, and UGT2A1, comparing the expression profile of the panel to a predetermined expression profile, wherein the subject's responsiveness is determined based on the comparison between the expression profile of the panel of gene markers and the predetermined expression profile, wherein the subject is determined to be responsive to the multikinase inhibitor treatment when the expression profile of any of the gene markers is within the predetermined expression profile, or when the expression profile of a panel of gene markers is similar to, or lower than, the predetermined expression profile, wherein the subject is determined to be not responsive to the multi-kinase inhibitor treatment when the expression profile of a panel of gene markers is not within the predetermined expression profile, or when the expression profile of a panel of gene markers is higher than the predetermined expression profile, and wherein the multi-kinase inhibitor targets to vascular endothelial growth factor (VEGF)-mediated angiogenesis and blocks the RAF/extracellular signal regulated kinase kinase /ERK cascade. measuring the expression profile of a panel of gene markers in a biological sample from the subject, wherein the panel of gene markers consists of one or more markers selected from the group consisting of SEC14L2, H6PD, TMEM140, SLC2A5, ACTA1, IRF8, STAT2, and UGT2A1, comparing the expression profile of the panel to a predetermined expression profile, wherein the subject's responsiveness is determined based on the comparison between the expression profile of the panel of gene markers and the predetermined expression profile, wherein the subject is determined to be responsive to the multikinase inhibitor treatment when the expression profile of any of the gene markers is within the predetermined expression profile, or when the expression profile of a panel of gene markers is similar to, or lower than, the predetermined expression profile, wherein the subject is determined to be not responsive to the multi-kinase inhibitor treatment when the expression profile of a panel of gene markers is not within the predetermined expression profile, or when the expression profile of a panel of gene markers is higher than the predetermined expression profile, and wherein the multi-kinase inhibitor targets to vascular endothelial growth factor (VEGF)-mediated angiogenesis and blocks the RAF/extracellular signal regulated kinase kinase /ERK cascade.
Azepine derivatives acting on a 5-HT 7 receptor, represented by Formula 1: wherein X is O and R 1 is selected from hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogenated C 1 -C 6 alkyl, and hydroxyl, or a pharmaceutically acceptable salt thereof.
A modular jewelry system comprising: at least one a jewelry body having a magnetic jewelry bases defining a first cavity configured to receive therein a first magnet, at least one a magnetic jewelry heads defining second cavity configured to receive therein second magnet, wherein said jewelry body has a male or female threaded portion, and said head has a threaded portion having threads of opposite gender to said threaded portion of said jewelry body for making engagement therewith when said head is magnetically coupled to said magnetic base, wherein when said first permanent magnet received in said first cavity, an outer side of said first permanent magnet has a first polarity and when said second permanent magnet is received in said second cavity, an outer side of said second permanent magnet has a second polarity that is opposite said first polarity, and wherein said outer side of said first permanent magnet and said outer side of said second permanent magnet face each other when said head is coupled to said body, characterized in that, a cavity formed between the base and the head is configured to receive a fingernail of a user to pry said head away from said base when said head and base are coupled together, and between said magnetic jewelry base and magnetic jewelry head is placed a gasket which seals with tight precision a space between said magnetic portions of said base and said head, when said head and base are coupled together. at least one a jewelry body having a magnetic jewelry bases defining a first cavity configured to receive therein a first magnet, at least one a magnetic jewelry heads defining second cavity configured to receive therein second magnet, wherein said jewelry body has a male or female threaded portion, and said head has a threaded portion having threads of opposite gender to said threaded portion of said jewelry body for making engagement therewith when said head is magnetically coupled to said magnetic base, wherein when said first permanent magnet received in said first cavity, an outer side of said first permanent magnet has a first polarity and when said second permanent magnet is received in said second cavity, an outer side of said second permanent magnet has a second polarity that is opposite said first polarity, and wherein said outer side of said first permanent magnet and said outer side of said second permanent magnet face each other when said head is coupled to said body, characterized in that, a cavity formed between the base and the head is configured to receive a fingernail of a user to pry said head away from said base when said head and base are coupled together, and between said magnetic jewelry base and magnetic jewelry head is placed a gasket which seals with tight precision a space between said magnetic portions of said base and said head, when said head and base are coupled together.
A monoclonal antibody or fragment thereof which inhibits MASP-2 by specifically binding to SEQ ID NO:6 for use in the treatment of age-related macular degeneration, or the prevention or treatment of an inflammatory reaction resulting from organ or tissue transplantation.
An optical image stabilizer for a telescopic optical instrument, the telescopic optical instrument having a telescopic optical system made up of an objective lens and an eyepiece lens arranged in this order and mounted on a telescope housing, the optical image stabilizer comprising: an erect prism (1, 1a, 1b) disposed between and coaxially with the objective lens and the eyepiece lens of the telescopic optical system, the erect prism (1, 1, 1b) being capable of rotating on first and second axes of rotation (54, 55) intersecting an optical axis of the telescopic optical system at a common point at right angles so as to compensate for deteriorations of a telescopic optical image caused due to external vibrations, gimbal means for mounting thereon the erect prism (1, 1a, 1b), said gimbal means comprising: a gimbal casing fixedly mounted on the telescope housing; an external gimbal frame rotatably mounted on the gimbal casing so as to rotate on the first axis of rotation; and an internal gimbal frame rotatably mounted on said external gimbal frame so as to rotate on the second axis of rotation, the erect prism (1, 1a, 1b) being fixedly mounted on said internal gimbal frame; a pair of voice coil motors (40, 40a, 40b) for rotating said external gimbal frame and said internal gimbal frame on the first and said second axes of rotation (54, 55), respectively, each said voice coil motor (40, 40a, 40b) comprising first yoke means (41, 41a, 41b) which has a permanent magnet (45, 45a, 45b) and second yoke means (42, 42a, 42b) which has a loop-shaped coil (43, 43a, 43b) with an empty space therein, and a position detector element (44, 44a, 44b) disposed in the empty space for providing a position signal indicating a position of said coil (43, 43a, 43b) relative to said permanent magnet (45, 45a, 45b); and a circuit board (48, 48a, 48b) fixedly mounted on said external gimbal frame, said circuit board (48, 48a, 48b) being provided thereon with a driver circuit for actuating each said voice coil motor (40, 40a, 40b); wherein said second yoke means (42, 42a, 42b) of each said voice coil motor (40, 40a, 40b) is mounted on said circuit board (48, 48a, 48b), said first yoke means (41, 41a, 41b) of said voice coil motor (40, 40a, 40b) for said external gimbal frame is mounted on said gimbal casing oppositely to said second yoke means (42, 42a, 42b) of said voice coil motor (40, 40a, 40b) for said external gimbal frame, and said first yoke means (41, 41a, 41b) of said voice coil motor (40, 40a, 40b) for said internal gimbal frame is mounted on said internal gimbal frame oppositely to said second yoke means (42, 42a, 42b) of said voice coil motor (40, 40a, 40b) for said internal gimbal frame. a gimbal casing fixedly mounted on the telescope housing; an external gimbal frame rotatably mounted on the gimbal casing so as to rotate on the first axis of rotation; and an internal gimbal frame rotatably mounted on said external gimbal frame so as to rotate on the second axis of rotation, the erect prism (1, 1a, 1b) being fixedly mounted on said internal gimbal frame;
Catalyst in the form of particles for the oxidative esterification of aldehydes to carboxylic esters, characterized in that the catalyst consists, except for oxygen, of a) 0.01 to 10 mol% of gold, b) 40 to 94 mol% of silicon, c) 3 to 40 mol% of aluminium and d) 2 to 40 mol% of at least one further element selected from alkali metals, alkaline earth metals, lanthanoids having atomic numbers 57 to 71, Y, Sc, Ti, Zr, Cu, Mn, Pb and/or Bi, where components b) to d) are present as oxides and the stated amounts of components a) to d) relate to 100 mol% of the composition of the catalyst without oxygen, in that the catalyst has a shell structure composed of a core and at least one shell, where at least 80% of the total amount of component a) is part of a shell, and in that the catalyst has a PZC value between 7 and 11, where the PZC value is determined as described in the description. in that the catalyst has a shell structure composed of a core and at least one shell, where at least 80% of the total amount of component a) is part of a shell, and in that the catalyst has a PZC value between 7 and 11, where the PZC value is determined as described in the description.
A method for installing an apparatus for monitoring physical parameters in an annulus of an oil and/or gas well having a well head, which apparatus comprises a sensor plug including a sensor and a flange assembly arranged with a bore holding a signal processing unit for communication with the sensor, wherein the method comprises the following steps; - installing the sensor plug including the sensor in a passage in the well head, which passage communicates with an annulus of the well, characterized in -connecting a cable connector to the sensor plug, which cable connector is attached to an end of a cable, connecting the sensor of the sensor plug to the signal processing unit in the bore of the flange assembly, - positioning the bore of the flange assembly essentially coinciding with the passage of the well head thereby inserting the cable connector into the bore and attaching the flange assembly to the well head thereby. - installing the sensor plug including the sensor in a passage in the well head, which passage communicates with an annulus of the well, -connecting a cable connector to the sensor plug, which cable connector is attached to an end of a cable, connecting the sensor of the sensor plug to the signal processing unit in the bore of the flange assembly, - positioning the bore of the flange assembly essentially coinciding with the passage of the well head thereby inserting the cable connector into the bore and attaching the flange assembly to the well head thereby.
A pump comprising: a pump chamber including an inlet and an outlet; a shaft at least partially positioned in the pump chamber; an impeller coupled to the shaft; a seal coupled to the shaft; and a wet seal chamber, the wet seal chamber including: a back wall and a separator spaced apart from the back wall, the separator including a disc and a resilient member, the back wall including a flange that extends toward the separator contacting the resilient member between the flange and the disc, the disc including at least one slot through which a fluid pressure from the pump chamber is transferred to the resilient member, the wet seal chamber substantially preventing fluid in the pump chamber from contacting the seal in order to prolong a life of the seal. a pump chamber including an inlet and an outlet; a shaft at least partially positioned in the pump chamber; an impeller coupled to the shaft; a seal coupled to the shaft; and a wet seal chamber, the wet seal chamber including: a back wall and a separator spaced apart from the back wall, the separator including a disc and a resilient member, the back wall including a flange that extends toward the separator contacting the resilient member between the flange and the disc, the disc including at least one slot through which a fluid pressure from the pump chamber is transferred to the resilient member, the wet seal chamber substantially preventing fluid in the pump chamber from contacting the seal in order to prolong a life of the seal. a back wall and a separator spaced apart from the back wall, the separator including a disc and a resilient member, the back wall including a flange that extends toward the separator contacting the resilient member between the flange and the disc, the disc including at least one slot through which a fluid pressure from the pump chamber is transferred to the resilient member, the wet seal chamber substantially preventing fluid in the pump chamber from contacting the seal in order to prolong a life of the seal.
A method for cleaning at least one soiled substrate in a rotatably mounted cylindrical drum of a cleaning apparatus, wherein the method comprises operating the cleaning apparatus for a wash cycle wherein during said wash cycle the drum is caused to rotate such that said at least one soiled substrate describes an annular path whereby a central portion of the drum is not occupied by any soiled substrate and a multiplicity of solid particles is introduced into said central portion of the drum for a first period and wherein the drum is further caused to rotate such that said at least one soiled substrate does not describe an annular path for a second period, and wherein said drum is caused to rotate at a G force of at least 1 for said first period, and further wherein said drum is caused to rotate at a G force of less than 1 for said second period.
A disk-shaped blank which is made of a final-strength dental ceramic and suitable for use in a method for producing ceramic dental prosthesis parts, characterized in that the disk-shaped blank includes at least one axially extending recess (24.1, 24.2) on each of its opposite sides, wherein the recesses (24.1, 24.2) are not extending through the entire thickness, wherein the depths of the recesses (24.1, 24.2) in sum amounts to at least the thickness of the disk-shaped blank, and wherein each recess (24.1.,24.2) is sufficient for a grinding tool of a CAD/CAM machining station to engage in the axial direction for the initial contact.
Cooking appliance comprising a cooking chamber, and comprising a door which is designed to close the cooking chamber, and comprising a stowing space which is separate from the cooking chamber and into which the door can be lowered in the open state, wherein the door is guided by a guide device of the cooking appliance as the door is moved into the stowing space or out of the stowing space, and the guide device has a guide unit having two separate guide elements (24, 26), and the guide device has at least one slotted guide (27, 33, 39) in which a guide unit of the guide device is guided, and the guide unit is connected to the door, wherein the guide unit has a guide bracket, the two separate guide elements (24, 26) being arranged thereon, and said guide elements being arranged at different height positions, when viewed in the height direction (y), wherein the guide element which is lower in the height position moves on a lower guide track and is arranged without contact with an upper guide track, which is separate from the lower guide track, and the guide element which is higher in the height position moves on the upper guide track and is arranged without contact with the lower guide track, characterised in that the cooking appliance has at least one damping unit which, starting from an intermediate position of the door which is between a completely open end position of the door and a completely closed end position of the door on the closing path of the door, is coupled to the guide unit such that at least a partial closing path is damped as the door is closed between the intermediate position and the completely closed end position of the door.
A method for tracking content in messages transmitted in a mobile communication network, the method comprising: maintaining, in a database (205, 604) predefined identifying information pertaining to content to be tracked, the identifying information being independent of user information associated with the content, and the identifying information comprising one or more of the following: a text length and a string indicating word lengths of the content to be tracked; intercepting a message transmitted over the mobile communication network from a first user to another user, comparing (2-7, 302) content of said message with said predefined identifying information, if a match is not obtained in said comparing, concluding that said message does not comprise content to be tracked and attaching additional content including advertising to the message before forwarding the message to said other user, and if at least a partial match is obtained in said comparing, concluding that said message comprises content to be tracked. maintaining, in a database (205, 604) predefined identifying information pertaining to content to be tracked, the identifying information being independent of user information associated with the content, and the identifying information comprising one or more of the following: a text length and a string indicating word lengths of the content to be tracked; intercepting a message transmitted over the mobile communication network from a first user to another user, comparing (2-7, 302) content of said message with said predefined identifying information, if a match is not obtained in said comparing, concluding that said message does not comprise content to be tracked and attaching additional content including advertising to the message before forwarding the message to said other user, and if at least a partial match is obtained in said comparing, concluding that said message comprises content to be tracked.
A battery module (10, 10A), comprising: a battery stack including cells that are tabular and laminated on one another; and a module reinforcement plate (110, 120) that is metallic and disposed in at least a position that substantially covers an entirety of a second outer surface having a maximum area, the position being included in positions that cover a plurality of outer surfaces excluding a pair of first outer surfaces at both outer sides along a lamination direction of the battery stack, wherein the module reinforcement plate (110, 120) includes a protrusion that engages with an opening formed on a module fixing plate for fixing the battery module (10, 10A) in a predetermined position on a placement surface on which the battery module (10, 10A) is placed. a battery stack including cells that are tabular and laminated on one another; and a module reinforcement plate (110, 120) that is metallic and disposed in at least a position that substantially covers an entirety of a second outer surface having a maximum area, the position being included in positions that cover a plurality of outer surfaces excluding a pair of first outer surfaces at both outer sides along a lamination direction of the battery stack, wherein the module reinforcement plate (110, 120) includes a protrusion that engages with an opening formed on a module fixing plate for fixing the battery module (10, 10A) in a predetermined position on a placement surface on which the battery module (10, 10A) is placed.
Wind turbine, including a tower, a nacelle, at least a rotatable blade, the wind turbine comprising an object position and/or speed and/or size detection device installed on said wind turbine for detecting a target object in the surroundings of the tower of the wind turbine, in particular the target object being the rotatable blade, characterized in that said detection device comprises - at least one coaxial leaky cable, - at least one electromagnetic transmitter connected to the least one coaxial leaky cable for transmitting a first electromagnetic signal along the at least one coaxial leaky cable towards a target object, whose position and/or speed and/or size is to be detected, - at least one electromagnetic receiver connected to the at least one coaxial leaky cable for receiving from the at least one coaxial leaky cable a second electromagnetic signal, said second electromagnetic signal being reflected from the target object when the first electromagnetic signal hits the target object, - a processing unit connected to the electromagnetic transmitter and the electromagnetic receiver and configured to analyse said first electromagnetic signal and said second electromagnetic signal for determining the position and/or speed and/or direction and/or the size of the target object, wherein any one of the coaxial leaky cables and/or the at least one electromagnetic transmitter and/or the least one electromagnetic receiver are configured to be installed on or inside the tower of the wind turbine. - at least one coaxial leaky cable, - at least one electromagnetic transmitter connected to the least one coaxial leaky cable for transmitting a first electromagnetic signal along the at least one coaxial leaky cable towards a target object, whose position and/or speed and/or size is to be detected, - at least one electromagnetic receiver connected to the at least one coaxial leaky cable for receiving from the at least one coaxial leaky cable a second electromagnetic signal, said second electromagnetic signal being reflected from the target object when the first electromagnetic signal hits the target object, - a processing unit connected to the electromagnetic transmitter and the electromagnetic receiver and configured to analyse said first electromagnetic signal and said second electromagnetic signal for determining the position and/or speed and/or direction and/or the size of the target object,
Arrangement of an actuating cam for a fuel pump at a coupling end of the crankshaft that faces the flywheel of an engine which comprises - a crankcase comprising a crank chamber delimited by a wall having an orifice surrounding the end of a crankshaft housed in said chamber, - and the flywheel fixed in a rotationally locked manner with said end and arranged outside said chamber, said flywheel comprising a tubular protuberance designed to surround the end of the crankshaft, said protuberance of the flywheel leaving inside the chamber through the circular orifice, characterized in that the actuating cam is borne by the tubular protuberance and fixed to the flywheel. - a crankcase comprising a crank chamber delimited by a wall having an orifice surrounding the end of a crankshaft housed in said chamber, - and the flywheel fixed in a rotationally locked manner with said end and arranged outside said chamber, said flywheel comprising a tubular protuberance designed to surround the end of the crankshaft, said protuberance of the flywheel leaving inside the chamber through the circular orifice,