A method of operating a time-interleaved analog-to-digital converter for conversion of an integer number L of analog input signals (301, 401) to L corresponding digital output signals, (302,402) wherein L is larger than 1, the analog input signals and digital output signals are indexed by i = 1, 2,..., L, each of the L digital output signals has a respective sample rate R i, at least two of the sample rates R i, i = j,k differ from each other such that R j > R k, and the time-interleaved analog-to-digital converter comprises an array of an integer number N of constituent analog-to-digital converters (321, 322, 323, 421, 422, 423) each having an analog input and a digital output, wherein N is larger than L, the method comprising: selecting (130, 230), for each of the L analog input signals (110, 210), a number N i of constituent analog-to-digital converters from the array of N constituent analog-to-digital converters by selecting N i, i = j,k such that R j R k ≤ N j N k, wherein N i is larger than or equal to 1 and ∑ i = 1 L N i ≤ N; putting un-selected constituent analog-to-digital converters in a low power mode; and for each of the L analog input signals (110, 210): sampling (120, 250) the analog input signal before or after splitting the analog input signal into N i signal streams, wherein each signal stream has a sample rate of R i /N i; digitizing (160, 260) each sample of the analog input signal in a respective one of the selected N i constituent analog-to-digital converters; and multiplexing (170, 270) the digitized samples of each of the selected N i constituent analog-to-digital converters to produce the digital output signal of rate R i corresponding to the analog input signal. selecting (130, 230), for each of the L analog input signals (110, 210), a number N i of constituent analog-to-digital converters from the array of N constituent analog-to-digital converters by selecting N i, i = j,k such that R j R k ≤ N j N k, wherein N i is larger than or equal to 1 and ∑ i = 1 L N i ≤ N; putting un-selected constituent analog-to-digital converters in a low power mode; and for each of the L analog input signals (110, 210): sampling (120, 250) the analog input signal before or after splitting the analog input signal into N i signal streams, wherein each signal stream has a sample rate of R i /N i; digitizing (160, 260) each sample of the analog input signal in a respective one of the selected N i constituent analog-to-digital converters; and multiplexing (170, 270) the digitized samples of each of the selected N i constituent analog-to-digital converters to produce the digital output signal of rate R i corresponding to the analog input signal. sampling (120, 250) the analog input signal before or after splitting the analog input signal into N i signal streams, wherein each signal stream has a sample rate of R i /N i; digitizing (160, 260) each sample of the analog input signal in a respective one of the selected N i constituent analog-to-digital converters; and multiplexing (170, 270) the digitized samples of each of the selected N i constituent analog-to-digital converters to produce the digital output signal of rate R i corresponding to the analog input signal.