mhurhangee/ep-ind-claims huggingface dataset:
A folding bicycle comprising: a first frame section; a second frame section movably mounted to the first frame section so that the first and second frame sections may be moved relative to each other from an unfolded position to a folded position; a front wheel mounted to the first frame section; a rear wheel mounted to the second frame section; a chain set mounted to the first frame section and defining an axis of rotation which constitutes a crank shaft axis; and a bottom bracket axle; characterized in that the bottom bracket axle comprises first and second axle members extending orthogonally to the axis of rotation and a bridge portion connecting the first and second axle members, wherein the bridge portion of the bottom bracket axle is offset from the crank shaft axis, the bottom bracket axle defining a void between the first and second axle members, and wherein, when in the folded position, the front and rear wheels are positioned at least partially within the void defined between the first and second axle members. a first frame section; a second frame section movably mounted to the first frame section so that the first and second frame sections may be moved relative to each other from an unfolded position to a folded position; a front wheel mounted to the first frame section; a rear wheel mounted to the second frame section; a chain set mounted to the first frame section and defining an axis of rotation which constitutes a crank shaft axis; and a bottom bracket axle; characterized in that the bottom bracket axle comprises first and second axle members extending orthogonally to the axis of rotation and a bridge portion connecting the first and second axle members, wherein the bridge portion of the bottom bracket axle is offset from the crank shaft axis, the bottom bracket axle defining a void between the first and second axle members, and wherein, when in the folded position, the front and rear wheels are positioned at least partially within the void defined between the first and second axle members.
Device for carrying out a chemical reaction by a continuous method, wherein said device has a reactor with at least two reactor sections which define a direction of flow, and wherein the reactor has plug flow properties along the direction of flow and over the whole length of the reactor, characterized in that a recirculation line is provided in order to withdraw a partial flow from the reactor at a first point and return it to the reactor at a second point located above the first point in the direction of flow, and wherein at least one means is provided that prevents a temperature increase in the reactor over a predetermined temperature range, specifically a temperature change of more than approximately 50 K, wherein the means comprises multiple temperature sensors which are arranged in series in the direction of flow and which measure the temperature or temperature changes in the reactor and wherein a control unit is provided that controls a recirculation rate of the recirculation line according to the value measured by the temperature sensor.
A valve opening and closing timing control apparatus comprising: a driving side rotor that synchronously rotates with a crankshaft of an internal combustion engine; a driven side rotor that is disposed coaxially with a rotary axis of the driving side rotor and synchronously rotates with a camshaft for valve opening and closing; a connecting bolt that is disposed coaxially with the rotary axis, and connects the driven side rotor to the camshaft; and a position determination unit (FB, RB) that performs positioning between the driven side rotor and the camshaft, or in a case where an intermediate member is provided between the driven side rotor and the camshaft, between the driven side rotor and the intermediate member, or between the camshaft and the intermediate member, wherein the position determination unit (FB, RB) includes an engaging pin (71, 72) that is in a posture parallel to the rotary axis, a first hole portion (FH1, RH1) into which one end of the engaging pin (71, 72) is fitted is provided in any one of two members performing the positioning, a second hole portion (FH2, RH2) in which the other end of the engaging pin (71, 72) is inserted is provided in the other one, and a deformation absorbing unit that suppresses deformation at a time when the engaging pin (71, 72) is fitted is provided in the vicinity of the first hole portion (FH1, RH1). a driving side rotor that synchronously rotates with a crankshaft of an internal combustion engine; a driven side rotor that is disposed coaxially with a rotary axis of the driving side rotor and synchronously rotates with a camshaft for valve opening and closing; a connecting bolt that is disposed coaxially with the rotary axis, and connects the driven side rotor to the camshaft; and a position determination unit (FB, RB) that performs positioning between the driven side rotor and the camshaft, or in a case where an intermediate member is provided between the driven side rotor and the camshaft, between the driven side rotor and the intermediate member, or between the camshaft and the intermediate member,
An activatable antibody comprising: an antibody or antibody fragment which antibody or fragment binds to a target which is EGFR, wherein the AB comprises (i) the variable region of the heavy chain amino acid sequence of SEQ ID NO: 222 and (ii) the variable region of the light chain amino acid sequence of SEQ ID NO: 230, a masking moiety that inhibits the specific binding of the AB of the AA in an uncleaved state to the target, wherein: the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); a cleavable moiety, wherein the CM is a polypeptide that functions as a substrate for a uPA protease, wherein the CM comprises the amino acid sequence selected from the group consisting of: TGRGPSWV (SEQ ID NO: 267), LSGRSDNH (SEQ ID NO: 270), and PLTGRSGG (SEQ ID NO: 273); and linker moieties L1 coupling the MM to the CM and L2 coupling the CM to the AB, wherein the AA in the uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: -L1- -L2-, wherein L2 links the CM to the N-terminal light chain of the AB, and wherein the L1 and L2 are each flexible linkers comprising glycine or glycine and serine. an antibody or antibody fragment which antibody or fragment binds to a target which is EGFR, wherein the AB comprises (i) the variable region of the heavy chain amino acid sequence of SEQ ID NO: 222 and (ii) the variable region of the light chain amino acid sequence of SEQ ID NO: 230, a masking moiety that inhibits the specific binding of the AB of the AA in an uncleaved state to the target, wherein: the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); a cleavable moiety, wherein the CM is a polypeptide that functions as a substrate for a uPA protease, wherein the CM comprises the amino acid sequence selected from the group consisting of: TGRGPSWV (SEQ ID NO: 267), LSGRSDNH (SEQ ID NO: 270), and PLTGRSGG (SEQ ID NO: 273); and linker moieties L1 coupling the MM to the CM and L2 coupling the CM to the AB, wherein the AA in the uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: -L1- -L2-, wherein L2 links the CM to the N-terminal light chain of the AB, and wherein the L1 and L2 are each flexible linkers comprising glycine or glycine and serine.
An arrangement (10, 82) for locking and unlocking a lock device (58, 74), the arrangement (10, 82) comprising: - a transfer element movable between a protruded position and a retracted position; - a core member of soft magnetic material, the core member comprising a coil section; - an electric coil wound around the coil section; and - a blocking member comprising a magnet, the blocking member being movable between a blocking position, in which the magnet establishes a magnetic circuit through the coil section and the blocking member blocks movement of the transfer element to the retracted position, and an unblocking position, in which the magnet establishes a magnetic circuit through the coil section and the blocking member unblocks movement of the transfer element to the retracted position. - a transfer element movable between a protruded position and a retracted position; - a core member of soft magnetic material, the core member comprising a coil section; - an electric coil wound around the coil section; and - a blocking member comprising a magnet, the blocking member being movable between a blocking position, in which the magnet establishes a magnetic circuit through the coil section and the blocking member blocks movement of the transfer element to the retracted position, and an unblocking position, in which the magnet establishes a magnetic circuit through the coil section and the blocking member unblocks movement of the transfer element to the retracted position.
Method for inputting a spatial layout of production devices, which together form a production plant, to a computer-aided planning program, • the production devices using real, two-dimensional or three-dimensional models (24, 25) which are true to scale at least in terms of their physical area requirement and are used to form a model layout of the production plant on a flat substrate, • the model layout being detected using a sensor, in particular an image sensor, • the position of the models (24, 25) being calculated by the planning program on the basis of the data detected by the sensor and being linked to data records of the production devices in the planning program, characterized in that • the data records of the production devices have data relating to the relevant area requirement of the production devices which goes beyond the physical area requirement, • overlaps of the respective relevant area requirement of adjacent production devices are determined, and • although the overlaps are allowed, they are displayed using an output device. • the production devices using real, two-dimensional or three-dimensional models (24, 25) which are true to scale at least in terms of their physical area requirement and are used to form a model layout of the production plant on a flat substrate, • the model layout being detected using a sensor, in particular an image sensor, • the position of the models (24, 25) being calculated by the planning program on the basis of the data detected by the sensor and being linked to data records of the production devices in the planning program, characterized in that • the data records of the production devices have data relating to the relevant area requirement of the production devices which goes beyond the physical area requirement, • overlaps of the respective relevant area requirement of adjacent production devices are determined, and • although the overlaps are allowed, they are displayed using an output device.
An operating apparatus for a medical apparatus, the operating apparatus comprising: a ring-shaped magnet magnetically polarized in a circumferential direction or a radial direction and configured to rotate along with rotating operation by a user; and a sensor unit configured to detect a magnetic field and to output a signal depending on the detected magnetic field, the sensor unit being located in an airtight and waterproof sealed structure. wherein the sensor unit outputs two-phase signals having different phases; and a partition which separates the ring-shaped magnet from the sensor unit but which does not shield a magnetic field. a ring-shaped magnet magnetically polarized in a circumferential direction or a radial direction and configured to rotate along with rotating operation by a user; and a sensor unit configured to detect a magnetic field and to output a signal depending on the detected magnetic field, the sensor unit being located in an airtight and waterproof sealed structure. wherein the sensor unit outputs two-phase signals having different phases; and a partition which separates the ring-shaped magnet from the sensor unit but which does not shield a magnetic field.
A drilling system, comprising: a rig; and a subsea wellhead assembly configured to perform a plurality of drilling functions; wherein an electrical power supply on the rig is connected to the subsea wellhead assembly via an electrical cable which provides power from the rig to the subsea wellhead assembly; wherein the system is configured so that at least a majority of the drilling functions of the subsea wellhead assembly are performed without supply of hydraulic control fluid from the rig and using electric power supplied from the rig via the electric cable as each of the said majority of drilling functions is performed; and the electrical power supply on the rig is connected to a backup power supply on the rig characterized in that the backup power supply on the rig comprises batteries, a capacitor bank or a flywheel-driven generator. a rig; and a subsea wellhead assembly configured to perform a plurality of drilling functions; wherein an electrical power supply on the rig is connected to the subsea wellhead assembly via an electrical cable which provides power from the rig to the subsea wellhead assembly; wherein the system is configured so that at least a majority of the drilling functions of the subsea wellhead assembly are performed without supply of hydraulic control fluid from the rig and using electric power supplied from the rig via the electric cable as each of the said majority of drilling functions is performed; and the electrical power supply on the rig is connected to a backup power supply on the rig characterized in that the backup power supply on the rig comprises batteries, a capacitor bank or a flywheel-driven generator.
An anti-CD33/anti-CD3 bispecific antibody comprising an anti-CD33 antibody or an antigen-binding fragment thereof and an anti-CD3 antibody or antigen-binding fragment thereof, wherein: the anti-CD33 antibody or antigen-binding fragment thereof comprises a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequence of SEQ ID NOs:447, 448, 449, 567, 568, and 569, respectively; the anti-CD3 antibody or antigen-binding fragment thereof comprises a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequence of: 1) SEQ ID NOs: 342, 343, 344, 465, 466, and 467, respectively; or 2) SEQ ID NOs: 345, 346, 347, 468, 469, and 470, respectively. the anti-CD33 antibody or antigen-binding fragment thereof comprises a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequence of SEQ ID NOs:447, 448, 449, 567, 568, and 569, respectively; the anti-CD3 antibody or antigen-binding fragment thereof comprises a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequence of: 1) SEQ ID NOs: 342, 343, 344, 465, 466, and 467, respectively; or 2) SEQ ID NOs: 345, 346, 347, 468, 469, and 470, respectively. 1) SEQ ID NOs: 342, 343, 344, 465, 466, and 467, respectively; or 2) SEQ ID NOs: 345, 346, 347, 468, 469, and 470, respectively.
A cleaning device comprising: a holding part holding an imaging element; a translucent body disposed in a visual field of the imaging element; a vibrating element configured to vibrate the translucent body; a control unit configured to control the vibrating element; a monitor part configured to detect an electrical characteristic value associated with a vibration of the vibrating element; and a storage part configured to store determination criteria based on which the control unit evaluates the electrical characteristic value detected by the monitor part, wherein the control unit is configured to evaluate the electrical characteristic value based on a plurality of the determination criteria stored in the storage part and clean a surface of the translucent body by controlling the vibrating element according to the determination, characterized in that the plurality of determination criteria includes a threshold with which the electrical characteristic value detected by the monitor part is compared, and a duration of control, and the control unit is configured to when the electrical characteristic value detected by the monitor part is greater than the threshold, cause the translucent body to vibrate at a first level, and even after a lapse of the duration of vibration at the first level, when the electrical characteristic value detected by the monitor part exceeds the threshold, control the vibrating element to cause the translucent body to vibrate at a second level different from the first level. a holding part holding an imaging element; a translucent body disposed in a visual field of the imaging element; a vibrating element configured to vibrate the translucent body; a control unit configured to control the vibrating element; a monitor part configured to detect an electrical characteristic value associated with a vibration of the vibrating element; and a storage part configured to store determination criteria based on which the control unit evaluates the electrical characteristic value detected by the monitor part, wherein the control unit is configured to evaluate the electrical characteristic value based on a plurality of the determination criteria stored in the storage part and clean a surface of the translucent body by controlling the vibrating element according to the determination, characterized in that the plurality of determination criteria includes a threshold with which the electrical characteristic value detected by the monitor part is compared, and a duration of control, and the control unit is configured to when the electrical characteristic value detected by the monitor part is greater than the threshold, cause the translucent body to vibrate at a first level, and even after a lapse of the duration of vibration at the first level, when the electrical characteristic value detected by the monitor part exceeds the threshold, control the vibrating element to cause the translucent body to vibrate at a second level different from the first level.
A yarn winding system comprising: an automatic winder configured to wind yarn from a yarn supply bobbin to form a package; and one or a plurality of previous step machines each configured to perform a process at a previous step for the automatic winder, wherein the automatic winder includes a yarn monitoring unit configured to detect a state of the yarn travelling and a transmission unit configured to transmit information on a monitoring result of the yarn monitoring unit to the previous step machine(s), and each of the previous step machines includes a receiving unit configured to receive the information on the monitoring result of the yarn monitoring unit from the automatic winder, characterized in that the automatic winder further includes a first abnormality information acquisition unit configured to acquire abnormality information on each of the previous step machines based on detection data detected by the yarn monitoring unit, and that the transmission unit is further configured to transmit the abnormality information as the information on the monitoring result. an automatic winder configured to wind yarn from a yarn supply bobbin to form a package; and one or a plurality of previous step machines each configured to perform a process at a previous step for the automatic winder, wherein the automatic winder includes a yarn monitoring unit configured to detect a state of the yarn travelling and a transmission unit configured to transmit information on a monitoring result of the yarn monitoring unit to the previous step machine(s), and each of the previous step machines includes a receiving unit configured to receive the information on the monitoring result of the yarn monitoring unit from the automatic winder, characterized in that the automatic winder further includes a first abnormality information acquisition unit configured to acquire abnormality information on each of the previous step machines based on detection data detected by the yarn monitoring unit, and that the transmission unit is further configured to transmit the abnormality information as the information on the monitoring result.
A compound, or pharmaceutically acceptable salt thereof, comprising a vascular disrupting agent which is an anti-cancer agent linked to a peptide comprising a matrix metalloproteinase proteolytic cleavage site comprising the amino acid sequence -Arg-Ser-Cit-Gly-Hof-Tyr-Leu-.
A preparation method for a zeolitic imidazolate framework, characterized in that the method comprises: Step 1: adding a metal carbonate or oxide and an organic ligand to a hydrophilic liquid to obtain a mixture; Step 2: introducing an acidic gas to reach a reaction pressure of 0.1 MPa to 2.0 MPa, maintaining the pressure for 30 to 60 minutes, and terminating the reaction; Step 3: heating to 30°C-60°C and vacuuming to obtain the zeolitic imidazolate framework, wherein the hydrophilic liquid comprises one or a combination of two or more of water, an alcohol, and an amide; wherein the acid gas is CO 2, H 2 S, SO 2, or NO 2; and wherein the organic ligand is one or a combination of two or more of imidazole, 2-methylimidazole, 2-ethylimidazole, 2-propylimidazole, and benzimidazole. Step 1: adding a metal carbonate or oxide and an organic ligand to a hydrophilic liquid to obtain a mixture; Step 2: introducing an acidic gas to reach a reaction pressure of 0.1 MPa to 2.0 MPa, maintaining the pressure for 30 to 60 minutes, and terminating the reaction; Step 3: heating to 30°C-60°C and vacuuming to obtain the zeolitic imidazolate framework, wherein the hydrophilic liquid comprises one or a combination of two or more of water, an alcohol, and an amide; wherein the acid gas is CO 2, H 2 S, SO 2, or NO 2; and wherein the organic ligand is one or a combination of two or more of imidazole, 2-methylimidazole, 2-ethylimidazole, 2-propylimidazole, and benzimidazole.