mhurhangee/ep-ind-claims huggingface dataset:
A composition for use in the treatment of tumors, characterized by that it contains - the compound of formula 44 and - a further anticancer drug; in the same or different specification unit preparations for simultaneous or separate administration, as well as a pharmaceutically acceptable carrier, wherein the anti-cancer drug is a drug for immunotherapy, wherein the immunotherapeutic drug is a PD-1 inhibitor, wherein the PD-1 inhibitor is an mPD-1 antibody. - the compound of formula 44 and - a further anticancer drug;
An extract obtained by extraction of a mushroom or a mushroom part with a non-polar or weakly polar solvent, for use in the treatment of a disease, disorder or condition connected with activation of human Liver X receptor, wherein the disease, disorder or condition is selected from the group consisting of: Syndrome X, hypercholesterolemia, hypertension, obesity, cardiovascular disorders, including coronary artery disorders, Diabetes type 2, Alzheimer's disease, CNS inflammation, fatty liver disease, dyslipidemia and neuronal damage, wherein the polarity of the non-polar or weakly polar solvent is defined by an E T value of 56 kcal/mol or lower, wherein the mushroom is from the genus Agaricus and, in an 5.8S/ITS nrDNA sequence, comprises the subsequence ITS1 nrDNA having an identity with <SEQ ID NO: 1> of at least 96.5, determined by means of the FASTA software, and wherein the extract comprises one or more compounds selected from the group consisting of compounds with the formula and or a hydrate or other solvate thereof.
A method of preventing muting of ongoing services of a multimedia broadcast and multicast service, MBMS, in a wireless communication network having a base station (14, 27) during multicast scheduling periods, MSPs, when a new multicast traffic channel, MTCH, is to be started, the method comprising: sending an indication of service start to trigger sending of a multicast control channel, MCCH, update during a first MCCH modification period to inform the base station (14, 27) of the new MTCH to be started during a second MCCH modification period at a time determined at the base station (14, 27); and sending control packet data units, PDUs, at least one MCCH modification time period prior to a time of MBMS data transfer as defined by a parameter in a MBMS session start request message and during an MCCH modification period preceding the second MCCH modification period, the PDUs arranged to avoid muting of the ongoing services. sending an indication of service start to trigger sending of a multicast control channel, MCCH, update during a first MCCH modification period to inform the base station (14, 27) of the new MTCH to be started during a second MCCH modification period at a time determined at the base station (14, 27); and sending control packet data units, PDUs, at least one MCCH modification time period prior to a time of MBMS data transfer as defined by a parameter in a MBMS session start request message and during an MCCH modification period preceding the second MCCH modification period, the PDUs arranged to avoid muting of the ongoing services.
A reaction-curable adhesive, comprising: an epoxy compound having two or more epoxy groups; and an amine compound having two or more amino groups, the reaction-curable adhesive being cured through a reaction between the epoxy compound and the amine compound, wherein the reaction-curable adhesive comprises, as the amine compound, a polyfunctional amine compound that is trifunctional or more, a Mannich-modified polyamine compound, and an amine-terminated butadiene-acrylonitrile copolymer (ATBN) having a structure represented by a general formula below, wherein the polyfunctional amine compound that is trifunctional or more is selected from trimethylolpropane poly(oxypropylene)triamine, triethylenetetramine and tetraethylenepentamine, and wherein the reaction-curable adhesive comprises bis[4-(glycidyloxy)phenyl]methane as the epoxy compound: where "X" represents a divalent organic group having one or two unsaturated bonds, the divalent organic group being obtained by removing two hydrogen atoms from an unsaturated hydrocarbon having 3 to 10 carbon atoms, and "n" represents an integer of 1 or more and 100 or less, and "m" represents an integer of 1 or more and 100 or less. an epoxy compound having two or more epoxy groups; and an amine compound having two or more amino groups, the reaction-curable adhesive being cured through a reaction between the epoxy compound and the amine compound, wherein the reaction-curable adhesive comprises, as the amine compound, a polyfunctional amine compound that is trifunctional or more, a Mannich-modified polyamine compound, and an amine-terminated butadiene-acrylonitrile copolymer (ATBN) having a structure represented by a general formula below, wherein the polyfunctional amine compound that is trifunctional or more is selected from trimethylolpropane poly(oxypropylene)triamine, triethylenetetramine and tetraethylenepentamine, and wherein the reaction-curable adhesive comprises bis[4-(glycidyloxy)phenyl]methane as the epoxy compound: where "X" represents a divalent organic group having one or two unsaturated bonds, the divalent organic group being obtained by removing two hydrogen atoms from an unsaturated hydrocarbon having 3 to 10 carbon atoms, and "n" represents an integer of 1 or more and 100 or less, and "m" represents an integer of 1 or more and 100 or less.
A heterodimer of fusion proteins comprising two different chains: first chain: VH(5T4)-CH1-L1-VH -L2-VL combined with second chain: VL(5T4)-CL-L1-VH(5T4)-L2-VL(5T4), wherein VH, VL are antibody variable binding domains, CH1 and CL are antibody constant domains and L1 and L2 are linkers, and wherein the heterodimer of fusion proteins contains one heterodimer interaction between the CH1 of the first chain and the CL antibody constant domain of the second chain, and the heterodimer of fusion proteins is such that (a) two combined VH/VL binding domains formed within said heterodimer of fusion proteins are capable of binding to the extracellular 5T4 antigen; and (b) the remaining one combined VH/VL binding domain formed within said heterodimer of fusion proteins is capable of binding to the CD3 receptor complex on T cells, wherein the first chain comprises or has SEQ ID NO. 51, and wherein the second chain comprises or has SEQ ID NO. 52. first chain: VH(5T4)-CH1-L1-VH -L2-VL combined with second chain: VL(5T4)-CL-L1-VH(5T4)-L2-VL(5T4), wherein VH, VL are antibody variable binding domains, CH1 and CL are antibody constant domains and L1 and L2 are linkers, and wherein the heterodimer of fusion proteins contains one heterodimer interaction between the CH1 of the first chain and the CL antibody constant domain of the second chain, and the heterodimer of fusion proteins is such that (a) two combined VH/VL binding domains formed within said heterodimer of fusion proteins are capable of binding to the extracellular 5T4 antigen; and (b) the remaining one combined VH/VL binding domain formed within said heterodimer of fusion proteins is capable of binding to the CD3 receptor complex on T cells, wherein the first chain comprises or has SEQ ID NO. 51, and wherein the second chain comprises or has SEQ ID NO. 52.
A dynamic bone fixation element configured to couple a load carrier to bone, the dynamic bone fixation element comprising: a sleeve that is elongate along a first direction, the sleeve defining a proximal end, a distal end spaced from the proximal end along the first direction, an outer surface that is configured to engage bone, and a channel that extends through the proximal end and at least toward the distal end along the first direction, at least a portion of the channel having a first cross-sectional dimension measured along a second direction, perpendicular to the first direction; and a fixation member having a head, a shaft that extends from the head along the first direction, and an abutment member that extends from the shaft such that at least a portion of the abutment member faces the head, the shaft configured to extend into the channel such that at least a portion of the sleeve is captured between the abutment member and the head to thereby couple the fixation member to the sleeve, wherein at least a portion of the shaft has a second cross-sectional dimension along the second direction, the second cross-sectional dimension being less than the first cross-sectional dimension such that the fixation member is moveable with respect to the sleeve along the second direction, and the channel and shaft have non-circular cross-sections that engage one another when the fixation member is coupled to the sleeve such that rotation of the fixation member causes the sleeve to rotate. a sleeve that is elongate along a first direction, the sleeve defining a proximal end, a distal end spaced from the proximal end along the first direction, an outer surface that is configured to engage bone, and a channel that extends through the proximal end and at least toward the distal end along the first direction, at least a portion of the channel having a first cross-sectional dimension measured along a second direction, perpendicular to the first direction; and a fixation member having a head, a shaft that extends from the head along the first direction, and an abutment member that extends from the shaft such that at least a portion of the abutment member faces the head, the shaft configured to extend into the channel such that at least a portion of the sleeve is captured between the abutment member and the head to thereby couple the fixation member to the sleeve, wherein at least a portion of the shaft has a second cross-sectional dimension along the second direction, the second cross-sectional dimension being less than the first cross-sectional dimension such that the fixation member is moveable with respect to the sleeve along the second direction, and the channel and shaft have non-circular cross-sections that engage one another when the fixation member is coupled to the sleeve such that rotation of the fixation member causes the sleeve to rotate.
An in vitro diagnostic method of assessing the susceptibility of a subject to develop progressive chronic obstructive pulmonary disease (COPD) involving the appearance of irreversible lung damage, wherein the subject has been diagnosed as suffering from stable COPD or is suspected to suffer from stable COPD, the method comprising: - determining the level of expression of the genes DMBT1 and KIAA1199 in a sample obtained from the subject; - comparing the level of expression of DMBT1 and KIAA1199 in the sample from the subject to a control expression level of DMBT1 and KIAA1199 in a healthy subject; and - determining whether or not the subject is prone to develop progressive COPD involving the appearance of irreversible lung damage, wherein an increase in the level of expression of DMBT1 and KIAA1199 in the sample from the subject as compared to the control expression level of DMBT1 and KIAA1199 is indicative of a proneness to develop progressive COPD. - determining the level of expression of the genes DMBT1 and KIAA1199 in a sample obtained from the subject; - comparing the level of expression of DMBT1 and KIAA1199 in the sample from the subject to a control expression level of DMBT1 and KIAA1199 in a healthy subject; and - determining whether or not the subject is prone to develop progressive COPD involving the appearance of irreversible lung damage, wherein an increase in the level of expression of DMBT1 and KIAA1199 in the sample from the subject as compared to the control expression level of DMBT1 and KIAA1199 is indicative of a proneness to develop progressive COPD.
Fixing arrangement of a radiator shield and a bumper on a front end mount of a motor vehicle, wherein the radiator shield and the bumper have at least one fixing part (26, 28) each, by means of which the radiator shield and the bumper are secured to the front end mount by way of an assigned screw element, characterised in that on the fixing part of the radiator shield, there is provided a connecting element, which, together with a corresponding receptacle of the fixing part of the bumper, is combined to form a common fastening device via which the radiator shield and the bumper are secured to the front end mount by way of the screw element, the common fastening device consisting of the connecting element of the radiator shield and the receptacle of the bumper.
Household linen for a double bed with two elongated panels (2.3) that: - are linked in at least one region, called the foot, (Rp) intended to be located at the foot end of the bed, - are free relative to each other on the major portion of their length up to a head edge (Bt) located opposite the foot region (Rp) - and partly overlap at a central longitudinal region (Rm) of the linen, so that the width (l l) of the linen is less than the sum of the width (lp) of the two panels(2,3), the middle region extending between the foot region (Rp) and the head edges (Bt), characterized in that each overlapping region (Rc) of each panel (2,3) is separated from the foot region by a cut-out substantially transverse to a longitudinal axis of the household linen. - are linked in at least one region, called the foot, (Rp) intended to be located at the foot end of the bed, - are free relative to each other on the major portion of their length up to a head edge (Bt) located opposite the foot region (Rp) - and partly overlap at a central longitudinal region (Rm) of the linen, so that the width (l l) of the linen is less than the sum of the width (lp) of the two panels(2,3), the middle region extending between the foot region (Rp) and the head edges (Bt),
A light-modulating material comprising a polycyclic aromatic hydrocarbon derivative that is a derivative of a polycyclic aromatic hydrocarbon having 10 to 500 aromatic rings and has a substituent represented by a following formula, formula, or formula: in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 6 is a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30, in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 7 and R 8 are each a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30, or, in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 3 and R 4 are carbon atoms; R 9 and R 10 are each a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30. in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 6 is a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30, in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 7 and R 8 are each a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30, or, in which R 1 and R 2 are carbon atoms of the aromatic rings in the polycyclic aromatic hydrocarbon; R 3 and R 4 are carbon atoms; R 9 and R 10 are each a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkoxy group (with an alkyl group having 1 to 20 carbon atoms), a cyano group, a nitro group, an amino group, an acylamino group, an alkylcarbonyl group, an arylcarbonyl group, or an acetoxy group; and m is a number of substituents and is 3 to 30.
Method for controlling and regulating a pressure (3,3a) of a cyclically operating injection moulding machine, comprising - providing a plasticised injection moulding material, - filling at least one cavity with the injection moulding material, - detecting an actual pressure (9, 9a), - switching to a holding pressure control phase at a changeover time, - starting from an actual pressure (9, 9a) measured at the changeover time, pre-setting a form of a curvature of a target pressure for a transition to the holding pressure control phase as a mathematical function for generating an at least partially curved target pressure curve, wherein the mathematical function defining the curvature is determined, detected and/or calculated, - wherein a time period from the changeover time to the holding pressure control phase until a holding pressure control profile of the holding pressure control phase is reached is preset as a function of at least one parameter and/or an operator input, and - wherein an initial gradient of the target pressure curve is preset at the changeover point. - providing a plasticised injection moulding material, - filling at least one cavity with the injection moulding material, - detecting an actual pressure (9, 9a), - switching to a holding pressure control phase at a changeover time, - starting from an actual pressure (9, 9a) measured at the changeover time, pre-setting a form of a curvature of a target pressure for a transition to the holding pressure control phase as a mathematical function for generating an at least partially curved target pressure curve, wherein the mathematical function defining the curvature is determined, detected and/or calculated, - wherein a time period from the changeover time to the holding pressure control phase until a holding pressure control profile of the holding pressure control phase is reached is preset as a function of at least one parameter and/or an operator input, and - wherein an initial gradient of the target pressure curve is preset at the changeover point.
A feedstock solution flow concentration process, which has a first step for counterflowing or parallel flowing a feedstock solution flow containing at least a solute and a solvent and a draw solution flow via a forward osmosis membrane and transferring the solvent in the feedstock solution flow to the draw solution flow to obtain a concentrated feedstock solution flow, which is the feedstock solution flow which has been concentrated, and a diluted draw solution flow, which is the draw solution flow which has been diluted, wherein the draw solution flow contains a draw substance, a common solute, and a solvent, the solvents of the feedstock solution flow and the draw solution flow both contain water, the common solute is a solute which is common between the feedstock solution flow and the draw solution flow and is the same solute as at least one type of solute among the solutes contained in the feedstock solution flow, and the concentration (mass %) of the common solute in the draw solution flow is 1% to less than 96% of the concentration (mass %) of the common solute in the feedstock solution flow. the draw solution flow contains a draw substance, a common solute, and a solvent, the solvents of the feedstock solution flow and the draw solution flow both contain water, the common solute is a solute which is common between the feedstock solution flow and the draw solution flow and is the same solute as at least one type of solute among the solutes contained in the feedstock solution flow, and the concentration (mass %) of the common solute in the draw solution flow is 1% to less than 96% of the concentration (mass %) of the common solute in the feedstock solution flow.
A filter assembly comprising: a filter comprising: a proximal portion comprising a plurality of support members having a major diameter; and a distal portion comprising a mesh having an opening diameter; and a filter wire attached to the filter, characterized in that the opening diameter is less than the major diameter in a free, expanded state, and each of the plurality of support members forms a bend corresponding to the major diameter by extending from the mesh outwardly relative to a central axis and back toward the central axis proximally from the bend to the filter wire. a filter comprising: a proximal portion comprising a plurality of support members having a major diameter; and a distal portion comprising a mesh having an opening diameter; and a filter wire attached to the filter, a proximal portion comprising a plurality of support members having a major diameter; and a distal portion comprising a mesh having an opening diameter; and a filter wire attached to the filter, characterized in that the opening diameter is less than the major diameter in a free, expanded state, and each of the plurality of support members forms a bend corresponding to the major diameter by extending from the mesh outwardly relative to a central axis and back toward the central axis proximally from the bend to the filter wire.
A method of processing a broadcast signal including service data and a service signaling channel, wherein the service signaling channel is carried in an Internet Protocol datagram, with a specific address and a specific port number and including a plurality of tables, wherein each table is identified by a table identifier and wherein the service data includes at least mobile service data for a mobile service or main service data for a main service in a broadcasting receiver, the method comprising: receiving the broadcast signal; parsing an emergency alert table contained in the service signaling channel of the broadcast signal, the emergency alert table comprising a message transfer type field (EAS_message_transfer_type) indicating one of a plurality of transfer types for an emergency message, and whereby said message transfer type may indicate that said emergency alert table comprises an emergency alert message of a text form and an emergency alert content transfer structure for signaling a rich media content that includes additional information related to the emergency alert message, the emergency alert content transfer structure comprising access information for access of the rich media content; acquiring the emergency alert message from the emergency alert table; and acquiring the rich media content from the broadcast signal based on the access information, wherein the rich media content includes at least one of an image, a text, an audio, and a video related to the emergency alert message. receiving the broadcast signal; parsing an emergency alert table contained in the service signaling channel of the broadcast signal, the emergency alert table comprising a message transfer type field (EAS_message_transfer_type) indicating one of a plurality of transfer types for an emergency message, and whereby said message transfer type may indicate that said emergency alert table comprises an emergency alert message of a text form and an emergency alert content transfer structure for signaling a rich media content that includes additional information related to the emergency alert message, the emergency alert content transfer structure comprising access information for access of the rich media content; acquiring the emergency alert message from the emergency alert table; and acquiring the rich media content from the broadcast signal based on the access information, wherein the rich media content includes at least one of an image, a text, an audio, and a video related to the emergency alert message.