mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising at least one type of recombinant adeno-associated viral vector encoding a CRISPR-Cas system directed to an autosomal dominant disease-related gene for use in treating an autosomal dominant ocular disease in a subject, the use comprising administering to the subject a therapeutically effective amount of the composition, wherein the at least one type of the AAV vector comprises: (a) two guide RNA sequences that hybridize to the endogenous autosomal dominant disease-related gene in the subject; (b) a second sequence comprising a codon-modified autosomal dominant disease-related gene or fragment thereof, wherein at least one disease related mutation has been corrected in the codon-modified autosomal dominant disease-related gene or fragment thereof, and wherein the codon-modified autosomal dominant disease-related gene or fragment thereof is not recognized by the guide RNA; and (c) a third sequence encoding a Cas nuclease, optionally Cas 9, wherein at least one guide RNA sequence is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, or combinations thereof. (a) two guide RNA sequences that hybridize to the endogenous autosomal dominant disease-related gene in the subject; (b) a second sequence comprising a codon-modified autosomal dominant disease-related gene or fragment thereof, wherein at least one disease related mutation has been corrected in the codon-modified autosomal dominant disease-related gene or fragment thereof, and wherein the codon-modified autosomal dominant disease-related gene or fragment thereof is not recognized by the guide RNA; and (c) a third sequence encoding a Cas nuclease, optionally Cas 9,
An EWOD device comprising a top substrate and a bottom substrate spaced apart from one another to define a fluid gap therebetween; wherein the device comprises at least M first temperature control elements (50a, 50b) and N second temperature control elements (52a,52b;54a,54b) for defining (M+N) respective zones of controllable temperature in the fluid gap, the first temperature control elements being in thermal contact with the first substrate and offset from one another along a direction parallel to the plane of the fluid gap, and the second temperature control elements being in thermal contact with the second substrate and offset from one another along the direction parallel to the plane of the fluid gap; wherein the first temperature control elements are offset, along the direction parallel to the plane of the fluid gap, relative to the second temperature control elements; and wherein the first and second temperature control elements are spaced along the direction parallel to the plane of the fluid gap such that the temperature within a zone of the zones of controllable temperature is determined by the temperature control element that defines that zone and by at least one other temperature control element.
A locking/releasing device for a cutting plate of a lawn mower, characterized in that it comprises a bar having through-holes (11, 111), and a bushing provided with a cavity closed at a head of the bushing and which develops from a mouth opposite to said head with respect to a longitudinal axis of the bushing, said bar being adapted to be partially inserted into said cavity of the bushing, said bushing further comprises two blocks which have respective through-holes facing the cavity and which are arranged at 180° with respect to each other so that said through-holes are aligned according to a transverse axis orthogonal to said longitudinal axis, said blocks extending laterally in the direction of the transverse axis beyond a side surface of the bushing, said device further comprises an elastic element adapted to elastically connect the head and the blocks of the bushing, said elastic element comprises a straight end adapted to be inserted into the through-holes of the two blocks and into one of the through-holes (11, 111) of the bar.
A method for configuring measurement information, comprising: receiving, by a terminal device, measurement information transmitted by a network device, wherein the measurement information comprises at least one physical-layer Cell identity, PCI; determining, by the terminal device, at least one cell according to the at least one PCI; and measuring, by the terminal device, signal quality of the at least one cell; wherein when the terminal device is in a connected state, the received measurement information further comprises first information corresponding to the at least one PCI, wherein the first information comprises an identity of at least one cell group to which the at least one cell belongs; and when the terminal device is in an idle state, the received measurement information further comprises a first frequency corresponding to the at least one PCI, wherein a priority of the first frequency is higher than a priority of a current camping frequency of the terminal device; and performing by the terminal device, cell selection and reselection according to measurement results of the at least one cell. receiving, by a terminal device, measurement information transmitted by a network device, wherein the measurement information comprises at least one physical-layer Cell identity, PCI; determining, by the terminal device, at least one cell according to the at least one PCI; and measuring, by the terminal device, signal quality of the at least one cell; wherein when the terminal device is in a connected state, the received measurement information further comprises first information corresponding to the at least one PCI, wherein the first information comprises an identity of at least one cell group to which the at least one cell belongs; and when the terminal device is in an idle state, the received measurement information further comprises a first frequency corresponding to the at least one PCI, wherein a priority of the first frequency is higher than a priority of a current camping frequency of the terminal device; and performing by the terminal device, cell selection and reselection according to measurement results of the at least one cell.
A method for synchronizing a popularity value of distributed cache data, wherein the method is applied to a radio access network, the radio access network comprises a popularity information synchronizing node and base stations (62, 64) managed by the popularity information synchronizing node, wherein a cache configured to store hot content is deployed in a distributed manner in the base stations (62, 64), and the method comprises: receiving, by a first base station of the radio access network, a request for accessing a packet domain service sent by a user equipment; responding to the packet domain service request, and if the first base station determines that the packet domain service is locally cached, sending the packet domain service to the user equipment and incrementing a current popularity value of the packet domain service in a list of locally cached content of the first base station according to a preset function; sending, by the first base station when the current popularity value of the packet domain service is accumulated to a preset threshold, the current popularity value of the packet domain service to the popularity information synchronizing node for synchronization, and clearing the current popularity value locally cached by the first base station; sending, by the first base station, a cached-content deletion request to the popularity information synchronizing node; receiving, by the first base station, a cached-content deletion response sent by the popularity information synchronizing node; and deleting, by the first base station, a packet domain service of locally cached content according to the cached-content deletion response. receiving, by a first base station of the radio access network, a request for accessing a packet domain service sent by a user equipment; responding to the packet domain service request, and if the first base station determines that the packet domain service is locally cached, sending the packet domain service to the user equipment and incrementing a current popularity value of the packet domain service in a list of locally cached content of the first base station according to a preset function; sending, by the first base station when the current popularity value of the packet domain service is accumulated to a preset threshold, the current popularity value of the packet domain service to the popularity information synchronizing node for synchronization, and clearing the current popularity value locally cached by the first base station; sending, by the first base station, a cached-content deletion request to the popularity information synchronizing node; receiving, by the first base station, a cached-content deletion response sent by the popularity information synchronizing node; and deleting, by the first base station, a packet domain service of locally cached content according to the cached-content deletion response.
Clearing blade, comprising - an interface for attaching the clearing blade to a vehicle; - at least a first blade (14, 16) and a second blade, which are connected to one another via a swivel joint (18, 20), the axis of rotation (38, 40) of which extends in upward direction of the clearing blade; - an adjusting apparatus for pivoting the blades (12, 14, 16) about the axis of rotation; - a rubber strip attached to the blades (12, 14, 16) and projecting downwards therefrom, characterised in that the neutral fiber of the rubber strip passes through the axis of rotation (38, 40) of the swivel joint (18, 20). - an interface for attaching the clearing blade to a vehicle; - at least a first blade (14, 16) and a second blade, which are connected to one another via a swivel joint (18, 20), the axis of rotation (38, 40) of which extends in upward direction of the clearing blade; - an adjusting apparatus for pivoting the blades (12, 14, 16) about the axis of rotation; - a rubber strip attached to the blades (12, 14, 16) and projecting downwards therefrom, characterised in that the neutral fiber of the rubber strip passes through the axis of rotation (38, 40) of the swivel joint (18, 20).
A casting process for manufacturing an engine, the casting process comprising: pouring a material in liquid state into a mold around a single-piece core within the mold, wherein an internal shape of the mold corresponds to an external shape of the engine, and wherein an external shape of the single-piece core corresponds to an internal shape of the engine; and solidifying the material to create a cast having an external shape corresponding to the internal shape of the mold, and having an internal shape corresponding to the external shape of the single-piece core. pouring a material in liquid state into a mold around a single-piece core within the mold, wherein an internal shape of the mold corresponds to an external shape of the engine, and wherein an external shape of the single-piece core corresponds to an internal shape of the engine; and solidifying the material to create a cast having an external shape corresponding to the internal shape of the mold, and having an internal shape corresponding to the external shape of the single-piece core.
A video encoding method comprising a resolution control, applied to a computing device, the computing device comprising a processor and a memory, and the method comprising: determining a quantization parameter threshold QPTH of a to-be-encoded current frame according to a preset rule; determining a quantization parameter estimated value of the current frame according to an encoding mode of an encoder; and determining encoding resolution of the current frame according to the quantization parameter threshold QPTH and the quantization parameter estimated value of the current frame; wherein the determining a quantization parameter threshold QPTH of a to-be-encoded current frame according to a preset rule comprises: determining the proportion of intra predicted blocks of the current frame such that if the average value of the intra-frame prediction block proportions of the N preceding frames is larger, a smaller quantization parameter threshold QPTH is set, and the current frame is downsampled encoded; otherwise, if the average value of the intra-frame prediction block proportion of the N preceding frames is smaller, a larger quantization parameter threshold QPTH is set and the frame is encoded at full resolution, wherein N is a positive integer greater than or equal to 1. determining a quantization parameter threshold QPTH of a to-be-encoded current frame according to a preset rule; determining a quantization parameter estimated value of the current frame according to an encoding mode of an encoder; and determining encoding resolution of the current frame according to the quantization parameter threshold QPTH and the quantization parameter estimated value of the current frame; wherein the determining a quantization parameter threshold QPTH of a to-be-encoded current frame according to a preset rule comprises: determining the proportion of intra predicted blocks of the current frame such that if the average value of the intra-frame prediction block proportions of the N preceding frames is larger, a smaller quantization parameter threshold QPTH is set, and the current frame is downsampled encoded; otherwise, if the average value of the intra-frame prediction block proportion of the N preceding frames is smaller, a larger quantization parameter threshold QPTH is set and the frame is encoded at full resolution, wherein N is a positive integer greater than or equal to 1.
An enclosure for providing a controlled environment comprising: a central plane extending through a top end of the enclosure and a bottom end of the enclosure and bisecting the enclosure along a width of the enclosure; an inlet at the bottom end of the enclosure having an inlet width, W inlet; an enclosure wall extending from the inlet to the top end of the enclosure, the enclosure wall comprising a chamber region and a transition region between the inlet and the chamber region, wherein a width of the chamber region, W chamber, is substantially constant through the chamber region, the width of the enclosure in the transition region decreases from W chamber to W inlet, and a ratio of W inlet to W chamber is from 1:2 to 1:5; an entry port at the top end of the enclosure configured to receive a part carrier; and an outlet between the entry port and the chamber region of the enclosure wall; wherein the central plane passes through the inlet and the entry port of the enclosure and the outlet extends along an outlet axis that is oriented at a non-zero angle with respect to the central plane. a central plane extending through a top end of the enclosure and a bottom end of the enclosure and bisecting the enclosure along a width of the enclosure; an inlet at the bottom end of the enclosure having an inlet width, W inlet; an enclosure wall extending from the inlet to the top end of the enclosure, the enclosure wall comprising a chamber region and a transition region between the inlet and the chamber region, wherein a width of the chamber region, W chamber, is substantially constant through the chamber region, the width of the enclosure in the transition region decreases from W chamber to W inlet, and a ratio of W inlet to W chamber is from 1:2 to 1:5; an entry port at the top end of the enclosure configured to receive a part carrier; and an outlet between the entry port and the chamber region of the enclosure wall; wherein the central plane passes through the inlet and the entry port of the enclosure and the outlet extends along an outlet axis that is oriented at a non-zero angle with respect to the central plane.
An aircraft system, comprising: a line capture device body (141; 441) having a line slot (144; 444), the line slot (144; 444) having an open end and a closed end; a retainer (146; 446) positioned proximate to the line slot (144; 444), the retainer (146; 446) including a rotor (147; 447) having a plurality of rotor arms (148; 448) positioned to extend at least partially across the line slot (144; 444) as the rotor (147; 447) rotates relative to the body (141; 441); a joint rotatably coupling the rotor (147; 447) to the body (141; 441); a ratchet device operably coupled to the rotor (147; 447) to allow the rotor (147; 447) to rotate in a first direction and at least restrict the rotor (147; 447) from rotating in a second direction opposite the first. a line capture device body (141; 441) having a line slot (144; 444), the line slot (144; 444) having an open end and a closed end; a retainer (146; 446) positioned proximate to the line slot (144; 444), the retainer (146; 446) including a rotor (147; 447) having a plurality of rotor arms (148; 448) positioned to extend at least partially across the line slot (144; 444) as the rotor (147; 447) rotates relative to the body (141; 441); a joint rotatably coupling the rotor (147; 447) to the body (141; 441); a ratchet device operably coupled to the rotor (147; 447) to allow the rotor (147; 447) to rotate in a first direction and at least restrict the rotor (147; 447) from rotating in a second direction opposite the first.
Method for controlling a combustion engine and the disengagement of the teeth of an internal transmission coupler, placed under the control of a gearshift actuator to engage or disengage a transmission ratio transmitting the torque supplied by the combustion engine connected to the input of the transmission without a decoupling clutch, wherein, when the combustion engine enters a critical situation in which there is a risk of stalling under deceleration in an engaged gear ratio, - a first critical zone, in which the actuator is forced to disengage the gear ratio in order to prevent stalling, is determined as a function of the speed (ω) of the combustion engine and of its deceleration, characterized in that, when the combustion engine enters said critical situation in which there is a risk of stalling under deceleration in an engaged gear ratio: - a second critical zone, in which the stalling of the engine is managed by preventing the injection of fuel, is determined as a function of the speed (ω) of the combustion engine and of its deceleration. - a first critical zone, in which the actuator is forced to disengage the gear ratio in order to prevent stalling, is determined as a function of the speed (ω) of the combustion engine and of its deceleration, characterized in that, when the combustion engine enters said critical situation in which there is a risk of stalling under deceleration in an engaged gear ratio: - a second critical zone, in which the stalling of the engine is managed by preventing the injection of fuel, is determined as a function of the speed (ω) of the combustion engine and of its deceleration. - a second critical zone, in which the stalling of the engine is managed by preventing the injection of fuel, is determined as a function of the speed (ω) of the combustion engine and of its deceleration.
A vacuum cleaner comprising: a main casing; a driving wheel for enabling the main casing to travel; control means for controlling drive of the driving wheel to make the main casing autonomously travel; a plurality of image pickup means (51a, 51b) disposed apart from each other in the main casing for picking up images on a traveling-direction side of the main casing so that their fields of view overlap with each other; distance image generation means for generating a distance image of an object positioned on the traveling-direction side based on the images picked up by the plurality of image pickup means (51a, 51b); and characterised in that the vacuum cleaner further comprises shape acquisition means for setting a specified distance or a specified distance range with respect to the distance image generated by the distance image generation means and acquiring shape information of the object positioned at the specified distance or within the specified distance range. a main casing; a driving wheel for enabling the main casing to travel; control means for controlling drive of the driving wheel to make the main casing autonomously travel; a plurality of image pickup means (51a, 51b) disposed apart from each other in the main casing for picking up images on a traveling-direction side of the main casing so that their fields of view overlap with each other; distance image generation means for generating a distance image of an object positioned on the traveling-direction side based on the images picked up by the plurality of image pickup means (51a, 51b); and characterised in that the vacuum cleaner further comprises shape acquisition means for setting a specified distance or a specified distance range with respect to the distance image generated by the distance image generation means and acquiring shape information of the object positioned at the specified distance or within the specified distance range.
Optical module (12, 14, 16) for a motor vehicle, comprising: - at least one light source capable of emitting laser radiation, - at least one shaping system able to receive the laser radiation and to direct it towards at least one conversion device for converting the laser radiation into white light, the conversion device comprising a layer of phosphorescent material and being able to re-emit the white light towards at least one optical system, and - a detector, characterised in that the shaping system and the optical system are located on the same side of the conversion device, the conversion device thus being used in reflection, and in that the detector is adapted to detect residual light emanating from the light source and coming from the conversion device, said residual light being formed by a portion which is reflected unconverted from the laser radiation received by the layer of phosphorescent material of the conversion device and thus being of the same wavelength as the light source, the residual light not passing through the optical system. - at least one light source capable of emitting laser radiation, - at least one shaping system able to receive the laser radiation and to direct it towards at least one conversion device for converting the laser radiation into white light, the conversion device comprising a layer of phosphorescent material and being able to re-emit the white light towards at least one optical system, and - a detector,
A method for preparing a fibrous scaffold comprising steps of: a) forming an electric field by applying a voltage using a voltage generator between a nozzle of a syringe containing a biodegradable polymer solution and a current-collecting ground, wherein the biodegradable polymer is polycaprolactone; and b) preparing a cotton-like fibrous scaffold having a three-dimensional volume by radially blowing the biodegradable polymer solution through the syringe nozzle under a continuous air flow by a fan. a) forming an electric field by applying a voltage using a voltage generator between a nozzle of a syringe containing a biodegradable polymer solution and a current-collecting ground, wherein the biodegradable polymer is polycaprolactone; and b) preparing a cotton-like fibrous scaffold having a three-dimensional volume by radially blowing the biodegradable polymer solution through the syringe nozzle under a continuous air flow by a fan.
An anti-pruritus agent for use in treating prurigo nodularis, said treatment comprising orally administering an effective amount of said anti-pruritus agent to a subject in need of such treatment, wherein the anti-pruritus agent is nalbuphine or a pharmaceutically acceptable salt or ester thereof.