A compound of Formula, or diastereomers, enantiomers, hydrates, solvates or pharmaceutically acceptable salts thereof: in the formula, X is O, or NH; Y is N or C-Z, wherein Z is -H or -CN; R 1 is R 3 is -H, halogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 alkyl substituted by halogen, or C 1 -C 3 alkoxy substituted by halogen; L is M is O or S; T is linear C 1 -C 3 alkyl, or linear C 1 -C 3 alkyl independently substituted by R 5 and R 6, respectively; R 5 and R 6 are independently -H, halogen, C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted by halogen; R 4 is aryl, 5- to 6-membered heteroaryl, aryl substituted by 1-3 identical or different R 7, or 5- to 6-membered heteroaryl substituted by 1-3 identical or different R 7, wherein the heteroaryl group is a heteroaryl group containing 1-3 heteroatoms selected from N, O or S; R 7 is -H, halogen, amino, hydroxy, cyano, C 1 -C 3 alkylthio, amino substituted with mono- or di-C 1 -C 3 alkyl, C 3 -C 4 cycloalkyl, unsubstituted or substituted C 1 -C 6 alkyl, or unsubstituted or substituted C 1 -C 6 alkoxy, wherein the substituent of the substituted C 1 -C 6 alkyl is halogen, hydroxy, amino substituted with mono- or di-C 1 -C 3 alkyl, or C 1 -C 3 alkoxy, and wherein the substituent of the substituted C 1 -C 6 alkoxy is halogen, C 1 -C 3 alkoxy, or amino substituted with mono- or di-C 1 -C 3 alkyl; R 2 is L 1 is selected from: T 1 is linear C 1 -C 8 alkyl, linear C 1 -C 8 alkyl independently substituted by R 9 and R 10, respectively; R 9 and R 10 are each independently -H, or C 1 -C 3 alkyl; R 8 is -H, hydroxy, C 1 -C 3 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 3 alkoxy, C 1 -C 3 alkylthio, 4- to 7-membered heterocyclyl or -NR 11 R 12; R 11 and R 12 are each independently -H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyl substituted by hydroxy, or C 1 -C 6 alkyl substituted by C 1 -C 3 alkoxy; the 4- to 7-membered heterocyclyl is a heterocyclyl containing 1-2 heteroatoms selected from N, O or S, the heterocyclyl is unsubstituted or substituted by one or two of the group consisting of: C 1 -C 3 alkyl, aldehyde group, C 1 -C 4 alkylacyl, aminoacyl, aminoacyl wherein the amino is substituted with mono- or di-C 1 -C 3 alkyl, C 1 -C 3 alkylsulfonyl, and C 1 -C 3 alkylsulfinyl, or the sulfur in the heterocycle is oxidized by one to two oxygen atoms. X is O, or NH; Y is N or C-Z, wherein Z is -H or -CN; R 1 is R 3 is -H, halogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 alkyl substituted by halogen, or C 1 -C 3 alkoxy substituted by halogen; L is M is O or S; T is linear C 1 -C 3 alkyl, or linear C 1 -C 3 alkyl independently substituted by R 5 and R 6, respectively; R 5 and R 6 are independently -H, halogen, C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted by halogen; R 4 is aryl, 5- to 6-membered heteroaryl, aryl substituted by 1-3 identical or different R 7, or 5- to 6-membered heteroaryl substituted by 1-3 identical or different R 7, wherein the heteroaryl group is a heteroaryl group containing 1-3 heteroatoms selected from N, O or S; R 7 is -H, halogen, amino, hydroxy, cyano, C 1 -C 3 alkylthio, amino substituted with mono- or di-C 1 -C 3 alkyl, C 3 -C 4 cycloalkyl, unsubstituted or substituted C 1 -C 6 alkyl, or unsubstituted or substituted C 1 -C 6 alkoxy, wherein the substituent of the substituted C 1 -C 6 alkyl is halogen, hydroxy, amino substituted with mono- or di-C 1 -C 3 alkyl, or C 1 -C 3 alkoxy, and wherein the substituent of the substituted C 1 -C 6 alkoxy is halogen, C 1 -C 3 alkoxy, or amino substituted with mono- or di-C 1 -C 3 alkyl; R 2 is L 1 is selected from: T 1 is linear C 1 -C 8 alkyl, linear C 1 -C 8 alkyl independently substituted by R 9 and R 10, respectively; R 9 and R 10 are each independently -H, or C 1 -C 3 alkyl; R 8 is -H, hydroxy, C 1 -C 3 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 3 alkoxy, C 1 -C 3 alkylthio, 4- to 7-membered heterocyclyl or -NR 11 R 12; R 11 and R 12 are each independently -H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkyl substituted by hydroxy, or C 1 -C 6 alkyl substituted by C 1 -C 3 alkoxy; the 4- to 7-membered heterocyclyl is a heterocyclyl containing 1-2 heteroatoms selected from N, O or S, the heterocyclyl is unsubstituted or substituted by one or two of the group consisting of: C 1 -C 3 alkyl, aldehyde group, C 1 -C 4 alkylacyl, aminoacyl, aminoacyl wherein the amino is substituted with mono- or di-C 1 -C 3 alkyl, C 1 -C 3 alkylsulfonyl, and C 1 -C 3 alkylsulfinyl, or the sulfur in the heterocycle is oxidized by one to two oxygen atoms.