mhurhangee/ep-ind-claims huggingface dataset:
Compound that functionally mimics a thioesterase enzymatic activity selected from the group consisting of: N-t-butyl hydroxylamine (NtBUHA), hydroxylamine, N-Methylhydroxylamine, N,N-Dimethylhydroxylamine, N,N-Diethylhydroxylamine, NCyclohexylhydroxylamine, N,O-Bis(trimethylsilyl) hydroxylamine, NBenzylhydroxylamine, N-Benzyloxycarbonyl), N,O-Di-Boc-hydroxylamine, N-Benzoyl-N-phenyl hydroxylamine, N,N-Dibenzylhydroxylamine, N-tert-Butyl-O-[1-[4-(chloromethyl) phenyl]ethyl]-N-(2-methyl-1-phenylpropyl) hydroxylamine, and pharmaceutically-acceptable salts thereof, for use in preventing, treating or ameliorating a disorder selected from lysosomal storage disorders, cancer or a metastasis thereof, and neurodegenerative diseases associated with a thioesterase deficiency.
A method of producing polyamide by a direct melt polymerization of a dicarboxylic acid component and a diamine component in the absence of a solvent in a repeated batch manner, which comprises: a step of feeding a solid or molten dicarboxylic acid component into a batch reactor and keeping a molten state of the dicarboxylic acid component therein; a step of adding the diamine component comprising 70 mol% or more of xylylenediamine continuously or intermittently to the dicarboxylic acid component kept in the molten state in the batch reactor; a step of introducing water vapor into the batch reactor after completing the addition of the diamine component; and a step of maintaining the pressure of the vapor phase in the batch reactor at a pressure higher than 0.1 MPaG, and continuing the melt polymerization after pressurizing the vapor phase in the batch reactor by introducing water vapor, at a temperature equal to or higher than the melting point of polyamide being produced and for at least 10 minutes, wherein the dicarboxylic acid component for the next batch production is supplied to the batch reactor in the presence of a remaining polyamide that is produced in a previous batch production, and wherein the amount of the remaining polyamide is 0.3 % by weight or more of the total amount of the remaining polyamide and the theoretical yield of polyamide calculated from amounts of a dicarboxylic acid component and a diamine component which are supplied to the batch reactor for the next batch production. a step of feeding a solid or molten dicarboxylic acid component into a batch reactor and keeping a molten state of the dicarboxylic acid component therein; a step of adding the diamine component comprising 70 mol% or more of xylylenediamine continuously or intermittently to the dicarboxylic acid component kept in the molten state in the batch reactor; a step of introducing water vapor into the batch reactor after completing the addition of the diamine component; and a step of maintaining the pressure of the vapor phase in the batch reactor at a pressure higher than 0.1 MPaG, and continuing the melt polymerization after pressurizing the vapor phase in the batch reactor by introducing water vapor, at a temperature equal to or higher than the melting point of polyamide being produced and for at least 10 minutes,
A sampling device of a liquid sensitive to contact with air, making it possible to decant said liquid, previously contained within an initial sealed container, into several final containers of a capacity that is less than that of the initial container, without any contact of the liquid with oxygen, the device comprising: - an inlet port of at least one initial container, providing an interface between the exterior exposed to ambient air and the inlet of an enclosure, and comprising at least one receiving means that communicates with the interior of the enclosure, - an enclosure wherein there prevails an inert atmosphere, and comprising: ∘ an opening station comprising an opening means of at least one initial container fitted into the at least one receiving means of the inlet port, ∘ a collection vessel, located beneath the opening station or communicating therewith in order to collect the liquid contained within the at least one initial container, ∘ a filling station for filling the final containers with liquid collected within the collection vessel, ∘ a sealing station for hermetically sealing the final containers, - an outlet port of the filled final containers, providing an interface between the outlet of the enclosure and the exterior which is exposed to ambient air. - an inlet port of at least one initial container, providing an interface between the exterior exposed to ambient air and the inlet of an enclosure, and comprising at least one receiving means that communicates with the interior of the enclosure, - an enclosure wherein there prevails an inert atmosphere, and comprising: ∘ an opening station comprising an opening means of at least one initial container fitted into the at least one receiving means of the inlet port, ∘ a collection vessel, located beneath the opening station or communicating therewith in order to collect the liquid contained within the at least one initial container, ∘ a filling station for filling the final containers with liquid collected within the collection vessel, ∘ a sealing station for hermetically sealing the final containers, ∘ an opening station comprising an opening means of at least one initial container fitted into the at least one receiving means of the inlet port, ∘ a collection vessel, located beneath the opening station or communicating therewith in order to collect the liquid contained within the at least one initial container, ∘ a filling station for filling the final containers with liquid collected within the collection vessel, ∘ a sealing station for hermetically sealing the final containers, - an outlet port of the filled final containers, providing an interface between the outlet of the enclosure and the exterior which is exposed to ambient air.
A connection apparatus for sealing to a pathway of a mounting structure, the connection apparatus comprising: a body; and a port including a threaded portion extending from the body and a non-threaded portion extending from the threaded portion, the non-threaded portion carrying a gasket, the gasket positioned along the non-threaded portion such that the mounting structure to which the connection apparatus is mounted contacts the gasket prior to the threaded portion engaging a mating threaded portion of the mounting structure, the port providing fluid communication between the body and the pathway of the mounting structure. a body; and a port including a threaded portion extending from the body and a non-threaded portion extending from the threaded portion, the non-threaded portion carrying a gasket, the gasket positioned along the non-threaded portion such that the mounting structure to which the connection apparatus is mounted contacts the gasket prior to the threaded portion engaging a mating threaded portion of the mounting structure, the port providing fluid communication between the body and the pathway of the mounting structure.
A server that manages a plurality of vehicles, each of the vehicles being configured to perform either or both of charging and discharging from and to a power grid when electrically connected to the power grid, the server comprising: a communication device that acquires data including location information of a target vehicle through communication, the target vehicle being a vehicle not connected to the power grid out of the vehicles; and a processor that sets a frequency of communication at which the data is acquired from the target vehicle, wherein the processor acquires the data from the target vehicle, the processor predicts connection time from the acquired data according to a prediction model and calculates confidence of the predicted connection time, the connection time being time when the target vehicle becomes connectable to the power grid, and the prediction model being a model that predicts the connection time based on the data from the target vehicle, and characterised in that the processor sets the frequency of communication according to the confidence a communication device that acquires data including location information of a target vehicle through communication, the target vehicle being a vehicle not connected to the power grid out of the vehicles; and a processor that sets a frequency of communication at which the data is acquired from the target vehicle, wherein the processor acquires the data from the target vehicle, the processor predicts connection time from the acquired data according to a prediction model and calculates confidence of the predicted connection time, the connection time being time when the target vehicle becomes connectable to the power grid, and the prediction model being a model that predicts the connection time based on the data from the target vehicle, and characterised in that the processor sets the frequency of communication according to the confidence
A laminate comprising at least one layer of a first thermoplastic resin composition alternately stacked with at least two layers of a second thermoplastic resin composition so that the outermost layers are the layers of the second thermoplastic resin composition, wherein the first thermoplastic resin composition comprises at least one selected from the group consisting of ethylene-vinyl alcohol copolymer and modified ethylene-vinyl alcohol copolymers, and the second thermoplastic resin composition has a different composition from the first thermoplastic resin composition and comprises a halogenated isoolefin-paraalkylstyrene copolymer rubber, and wherein, in any adjacent pair of the layer of the first thermoplastic resin composition and the layer of the second thermoplastic resin composition, the ratio E 1 /E 2 is more than 1 and up to 10, and the ratio t 1 /t 2 is 0.1 or more and up to 1, wherein E 1 and t 1 are the tensile modulus as measured in accordance with JIS K6251 at 25°C and thickness of the layer of the first thermoplastic resin composition and E 2 and t 2 are the tensile modulus as measured in accordance with JIS K6251 at 25°C and thickness of the layer of the second thermoplastic resin composition.
An apparatus comprising a computer implemented preference server configured to: communicate with a digital video recorder to retrieve a user profile stored in the DVR, wherein the user profile indicates programs recorded or scheduled for recording in the DVR; communicate with at least one content server having a library of programs available for online delivery from the at least one content server to a remote device; and deliver, to the remote device, a user menu providing a user-specific list of programs, which are based on said user profile retrieved from said DVR and comprise those of the programs recorded or scheduled for recording in the DVR that are also available for online delivery to the remote device from the at least one content server. communicate with a digital video recorder to retrieve a user profile stored in the DVR, wherein the user profile indicates programs recorded or scheduled for recording in the DVR; communicate with at least one content server having a library of programs available for online delivery from the at least one content server to a remote device; and deliver, to the remote device, a user menu providing a user-specific list of programs, which are based on said user profile retrieved from said DVR and comprise those of the programs recorded or scheduled for recording in the DVR that are also available for online delivery to the remote device from the at least one content server.
A method of storing streamed multimedia data of a multimedia item in a multimedia cache, the method comprising: receiving said streamed multimedia data as a plurality of multimedia data portions that are discontinuous as the result of at least one of - user input requesting a skip forward or backward in the stream of multimedia data, and - user input requesting multiple concurrent streams of multimedia data from the same data item; pre-storing said plurality of discontinuous multimedia data portions in a buffer In the order In which said portions are received; determining the temporal position of said pre-stored multimedia data portions in the multimedia data item; rearranging said pre-stored multimedia data portions in accordance with the determined temporal positions; combining portions containing uninterrupted consecutive sequences in the media data stream to form at least one temporally contiguous data portion; and storing each contiguous data portion as a single segment in a cache file. receiving said streamed multimedia data as a plurality of multimedia data portions that are discontinuous as the result of at least one of - user input requesting a skip forward or backward in the stream of multimedia data, and - user input requesting multiple concurrent streams of multimedia data from the same data item; - user input requesting a skip forward or backward in the stream of multimedia data, and - user input requesting multiple concurrent streams of multimedia data from the same data item; pre-storing said plurality of discontinuous multimedia data portions in a buffer In the order In which said portions are received; determining the temporal position of said pre-stored multimedia data portions in the multimedia data item; rearranging said pre-stored multimedia data portions in accordance with the determined temporal positions; combining portions containing uninterrupted consecutive sequences in the media data stream to form at least one temporally contiguous data portion; and storing each contiguous data portion as a single segment in a cache file.
Lamp, in particular a recessed luminaire, - with a mounting housing for installation in a wall and/or ceiling, which has an axially open receiving space, - with an insert which is placed into the receiving space and is firmly connected to the mounting housing, - wherein the insert comprises a support that has at least one illuminant, and - wherein the support comprises a light guide block which has an annular configuration and laterally encloses a central block opening, characterised, - in that the insert is fixed to the mounting housing with a fastening device, - in that the fastening device for fixing the insert on the mounting housing axially through this block opening is accessible through it, - in that the mounting housing is designed cup-shaped, wherein a pot bottom of the mounting housing is fastened to the insert with the fastening device, - in that a pot wall of the mounting housing laterally surrounds the receiving space, and - in that an annular space is formed radially between the pot wall and the insert. - with a mounting housing for installation in a wall and/or ceiling, which has an axially open receiving space, - with an insert which is placed into the receiving space and is firmly connected to the mounting housing, - wherein the insert comprises a support that has at least one illuminant, and - wherein the support comprises a light guide block which has an annular configuration and laterally encloses a central block opening, - in that the insert is fixed to the mounting housing with a fastening device, - in that the fastening device for fixing the insert on the mounting housing axially through this block opening is accessible through it, - in that the mounting housing is designed cup-shaped, wherein a pot bottom of the mounting housing is fastened to the insert with the fastening device, - in that a pot wall of the mounting housing laterally surrounds the receiving space, and - in that an annular space is formed radially between the pot wall and the insert.
A cell observation system for observing a cell moving in a flow path with a fluid, the system comprising: a first imaging apparatus including a first optical system and a first imaging element, the first imaging apparatus arranged to capture an image of the cell by receiving, by the first imaging element, light reaching the first imaging element from the cell at a first position in a moving direction of the cell in the flow path through the first optical system; a second imaging apparatus including a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, the second imaging apparatus arranged to capture an image of the cell by receiving, by the second imaging element, light reaching the second imaging element from the cell at a second position downstream of the first position in the moving direction of the cell in the flow path through the second optical system; and a control device arranged to input the image obtained by imaging by the first imaging element of the first imaging apparatus, analyze the image to obtain a passing position of the cell in a cross section of the flow path, and generate the focus adjustment signal based on the obtained passing position to provide the focus adjustment signal to the second optical system of the second imaging apparatus, wherein the cell is focused on a region near a center in the cross section of the flow path in advance upstream of the first position and the second position for restricting a focus deviation amount of the passing position of the cell. a first imaging apparatus including a first optical system and a first imaging element, the first imaging apparatus arranged to capture an image of the cell by receiving, by the first imaging element, light reaching the first imaging element from the cell at a first position in a moving direction of the cell in the flow path through the first optical system; a second imaging apparatus including a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, the second imaging apparatus arranged to capture an image of the cell by receiving, by the second imaging element, light reaching the second imaging element from the cell at a second position downstream of the first position in the moving direction of the cell in the flow path through the second optical system; and a control device arranged to input the image obtained by imaging by the first imaging element of the first imaging apparatus, analyze the image to obtain a passing position of the cell in a cross section of the flow path, and generate the focus adjustment signal based on the obtained passing position to provide the focus adjustment signal to the second optical system of the second imaging apparatus, wherein the cell is focused on a region near a center in the cross section of the flow path in advance upstream of the first position and the second position for restricting a focus deviation amount of the passing position of the cell.
A mobile aggregate processing plant comprising a mobile chassis and a crusher mounted on the mobile chassis via a mounting, characterised in that the mounting includes a plurality of height extenders able to move the crusher between a transport configuration and an operating configuration relative to the chassis, and therefore able to alter the overall height of the mobile aggregate processing plant between a transport configuration and an operating configuration.
Rope-pulley assembly for a starting apparatus for starting a combustion engine of a hand-held implement, comprising a rope pulley and a connecting spring, wherein a first end of the connecting spring is connected in a rotationally conjoint manner to the rope pulley, wherein the rope pulley has an axis of rotation extending in an axial direction, wherein the rope pulley has in its circumferential side situated at the outside in a radial direction an encircling depression for receiving a starting rope, and wherein the rope pulley has a spring receptacle for receiving the connecting spring, wherein, when seen both in the axial direction and in the radial direction, the spring receptacle and the depression overlap, wherein the spring receptacle comprises a spring chamber and a fitting region for connection to the connecting spring, wherein the fitting region and the depression are arranged so as to be situated adjacent to one another at least partially in the axial direction, wherein the connecting spring is fitted by way of the first end into the fitting region of the spring receptacle, wherein the connecting spring has a maximum width measured in the axial direction, characterized in that a width, measured in the axial direction, of the connecting spring at the first end thereof is less than the maximum width of the connecting spring.
Process for the preparation of a sugar product from lignocellulosic material, comprising the following steps: a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pre-treated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises GH61, and d) optionally, recovery of the sugar product, wherein during the enzymatic hydrolysis step (c) oxygen is added to the lignocellulosic material, the reactor for the enzymatic hydrolysis has a volume of 1 m 3 or more and the dry matter content in the hydrolysis step (c) is 10 to 33 wt%. a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pre-treated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises GH61, and d) optionally, recovery of the sugar product,
A cosmetic composition for topical application to skin, comprising: niacinamide; a ricinoleate compound selected from the group consisting of glyceryl ricinoleate, sodium ricinoleate, butyl acetyl ricinoleate and methyl ricinoleate; and a dermatologically acceptable carrier. niacinamide; a ricinoleate compound selected from the group consisting of glyceryl ricinoleate, sodium ricinoleate, butyl acetyl ricinoleate and methyl ricinoleate; and a dermatologically acceptable carrier.