A compound of Formula I-E: wherein A, B, C, and D are independently selected from CR 1 and N; wherein at least one of A, B, C, and D is CR 1; wherein R 1 is selected from H, alkyl, heteroalkyl, aryl, arylalkyl, halogen, CF 3, methoxy, -OR i, -SR ii, -S R ii, -S 2 R iv, and -C NR v R vi; and wherein when two adjacent of A, B, C, and D are CR 1, the two R 1 's may combine to form a single aryl, cycloalkyl, or heterocycloalkyl group; R 2 is selected from alkyl, heteroalkyl and arylalkyl; R 3 is selected from H, alkyl, heteroalkyl, and arylalkyl; or R 2 and R 3 together with the nitrogen group form an aliphatic amine; R i is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R ii is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R iii is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R iv is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; and R v and R vi are independently selected from H, methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, diethylaminoethyl, phenyl, pyridinyl, methoxyethyl, hydroxyethoxyethyl, benzyl, methylphenyl, phenylethyl, hydroxyhydroxymethylphenylethyl, carbamoylmethyl, and hydroxymethyl hydroxyethyl, or R v and R vi together form morpholine, piperazine, piperazine ethyl ester; or a pharmaceutically acceptable salt thereof for use in a method for prophylaxis or treatment of benign prostatic hyperplasia, an enlarged prostate, acute urinary retention, or symptoms thereof or reducing prostate size in a mammal. A, B, C, and D are independently selected from CR 1 and N; wherein at least one of A, B, C, and D is CR 1; wherein R 1 is selected from H, alkyl, heteroalkyl, aryl, arylalkyl, halogen, CF 3, methoxy, -OR i, -SR ii, -S R ii, -S 2 R iv, and -C NR v R vi; and wherein when two adjacent of A, B, C, and D are CR 1, the two R 1 's may combine to form a single aryl, cycloalkyl, or heterocycloalkyl group; R 2 is selected from alkyl, heteroalkyl and arylalkyl; R 3 is selected from H, alkyl, heteroalkyl, and arylalkyl; or R 2 and R 3 together with the nitrogen group form an aliphatic amine; R i is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R ii is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R iii is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; R iv is selected from methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, acetonitrile, phenyl, phenylmethoxy, phenylethoxy, phenylpropoxy, phenylbutoxy, and benzyl; and R v and R vi are independently selected from H, methyl, hydroxymethyl, ethyl, hydroxyethyl, propyl, hydroxypropyl, butyl, hydroxybutyl, diethylaminoethyl, phenyl, pyridinyl, methoxyethyl, hydroxyethoxyethyl, benzyl, methylphenyl, phenylethyl, hydroxyhydroxymethylphenylethyl, carbamoylmethyl, and hydroxymethyl hydroxyethyl, or R v and R vi together form morpholine, piperazine, piperazine ethyl ester; or a pharmaceutically acceptable salt thereof for use in a method for prophylaxis or treatment of benign prostatic hyperplasia, an enlarged prostate, acute urinary retention, or symptoms thereof or reducing prostate size in a mammal.