A multilayer surgical graft, comprising: a first remodelable extracellular matrix sheet; a second remodelable extracellular matrix sheet; and a synthetic mesh material with a plurality of mesh openings disposed between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, and said multilayer surgical graft further characterized by: a fill material residing in each of said mesh openings and having a passageway that traverses the entire thickness of the multilayer surgical graft including through a first mesh opening in said synthetic mesh material, wherein said passageway includes a composite passageway wall formed with material from at least said first remodelable extracellular matrix sheet, said fill material and said second remodelable extracellular matrix sheet; or said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet contacting and bonded to one another through said plurality of mesh openings to provide bonded regions between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet and including passageways extending through said first remodelable extracellular matrix sheet, through said mesh openings, and through said second remodelable extracellular matrix sheet within said bonded regions and wherein said bonded regions extend laterally beyond and fully around said passageways. a first remodelable extracellular matrix sheet; a second remodelable extracellular matrix sheet; and a synthetic mesh material with a plurality of mesh openings disposed between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, and said multilayer surgical graft further characterized by: a fill material residing in each of said mesh openings and having a passageway that traverses the entire thickness of the multilayer surgical graft including through a first mesh opening in said synthetic mesh material, wherein said passageway includes a composite passageway wall formed with material from at least said first remodelable extracellular matrix sheet, said fill material and said second remodelable extracellular matrix sheet; or said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet contacting and bonded to one another through said plurality of mesh openings to provide bonded regions between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet and including passageways extending through said first remodelable extracellular matrix sheet, through said mesh openings, and through said second remodelable extracellular matrix sheet within said bonded regions and wherein said bonded regions extend laterally beyond and fully around said passageways. a fill material residing in each of said mesh openings and having a passageway that traverses the entire thickness of the multilayer surgical graft including through a first mesh opening in said synthetic mesh material, wherein said passageway includes a composite passageway wall formed with material from at least said first remodelable extracellular matrix sheet, said fill material and said second remodelable extracellular matrix sheet; or said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet contacting and bonded to one another through said plurality of mesh openings to provide bonded regions between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet and including passageways extending through said first remodelable extracellular matrix sheet, through said mesh openings, and through said second remodelable extracellular matrix sheet within said bonded regions and wherein said bonded regions extend laterally beyond and fully around said passageways.