mhurhangee/ep-ind-claims huggingface dataset:
An isolated antibody or fragment thereof comprising a light chain CDR1 amino acid sequence comprising SEQ ID NO:224, a light chain CDR2 amino acid sequence comprising SEQ ID NO:225, a light chain CDR3 amino acid sequence comprising SEQ ID NO:226, a heavy chain CDR1 amino acid sequence comprising SEQ ID NO: 146, a heavy chain CDR2 amino acid sequence comprising SEQ ID NO:147, and a heavy chain CDR3 amino acid sequence comprising SEQ ID NO: 148, wherein said antibody or fragment thereof binds human IL-17 receptor A.
A method for predicting the risk of developing a disseminated infection in a patient admitted to intensive care having no clinical symptoms of such an infection, comprising the following steps: - determining a first dose of gelsolin G1 in a biological sample from said patient originating from a first sample taken at the time T1, carried out between the day of admission to intensive care and 48 hours afterward, - determining a second dose of gelsolin G2 in a biological sample from said patient originating from a second sample taken at the time T2, carried out two to three days after the first sampling, - calculating the variation between the dose of gelsolin G2 and the dose of gelsolin G1, giving a Δ value, - comparing the Δ value obtained in the preceding step to a threshold value S determined beforehand from two populations of patients admitted to intensive care, one not having developed a disseminated infection and the other having developed such an infection, • a Δ value lower than said threshold value S meaning that the patient admitted to intensive care is a patient at high risk of developing a disseminated infection, and • a Δ value greater than said threshold value S meaning that the patient admitted to intensive care is not a patient at high risk of developing a disseminated infection. - determining a first dose of gelsolin G1 in a biological sample from said patient originating from a first sample taken at the time T1, carried out between the day of admission to intensive care and 48 hours afterward, - determining a second dose of gelsolin G2 in a biological sample from said patient originating from a second sample taken at the time T2, carried out two to three days after the first sampling, - calculating the variation between the dose of gelsolin G2 and the dose of gelsolin G1, giving a Δ value, - comparing the Δ value obtained in the preceding step to a threshold value S determined beforehand from two populations of patients admitted to intensive care, one not having developed a disseminated infection and the other having developed such an infection, • a Δ value lower than said threshold value S meaning that the patient admitted to intensive care is a patient at high risk of developing a disseminated infection, and • a Δ value greater than said threshold value S meaning that the patient admitted to intensive care is not a patient at high risk of developing a disseminated infection. • a Δ value lower than said threshold value S meaning that the patient admitted to intensive care is a patient at high risk of developing a disseminated infection, and • a Δ value greater than said threshold value S meaning that the patient admitted to intensive care is not a patient at high risk of developing a disseminated infection.
A method comprising: identifying, by data processing hardware, a middlebox receiving network flow and communicating with one or more backend virtual machines; receiving, at the data processing hardware, flow statistics corresponding to the network flow of the middlebox; determining, by the data processing hardware, whether the flow statistics satisfy an offload rule, the offload rule indicating when to migrate the network flow from the middlebox to an end host (140, 150); and when the flow statistics satisfy the offload rule, migrating, by the data processing hardware, the network flow from the middlebox to the end host (140, 150); wherein migrating the network flow from the middlebox to the end host (140, 150) comprises initiating an end-host connection table at the end host (140, 150). identifying, by data processing hardware, a middlebox receiving network flow and communicating with one or more backend virtual machines; receiving, at the data processing hardware, flow statistics corresponding to the network flow of the middlebox; determining, by the data processing hardware, whether the flow statistics satisfy an offload rule, the offload rule indicating when to migrate the network flow from the middlebox to an end host (140, 150); and when the flow statistics satisfy the offload rule, migrating, by the data processing hardware, the network flow from the middlebox to the end host (140, 150); wherein migrating the network flow from the middlebox to the end host (140, 150) comprises initiating an end-host connection table at the end host (140, 150).
A process for the preparation of an aromatic amine by reacting a corresponding aromatic alcohol with an aminating agent selected from the group consisting of ammonia, primary amines and secondary amines, in the presence of hydrogen and a catalyst molding, at a temperature of from 60 to 300°, wherein the catalyst molding comprises Zr, Pd and Pt and has an annular tablet form with an external diameter in the range from 2 to 6 mm and a height in the range from 1 to 4 mm and an internal diameter of from 1 to 5 mm or a topologically equivalent form with the same volume, wherein a topologically equivalent form is understood to be a molding which is understood as elliptic, square, rectangular, triangular, rhombic, stellate and is provided with a cavity or hollow or hole and the volume of the topologically equivalent molding is selected such that the volume of the topologically equivalent molding is in the region of the volume of an annular tablet according to the invention according to the formula V = ((D A -D i) 2 ·π / 4)·h and the volume of the hollow or cavity of the topologically equivalent molding is accordingly selected such that the volume of the hollow or cavity is in the region of the volume of a hollow or cavity of an annular tablet according to the invention according to the formula V = (D i 2 ·π / 4)·h. is understood as elliptic, square, rectangular, triangular, rhombic, stellate and is provided with a cavity or hollow or hole and the volume of the topologically equivalent molding is selected such that the volume of the topologically equivalent molding is in the region of the volume of an annular tablet according to the invention according to the formula V = ((D A -D i) 2 ·π / 4)·h and the volume of the hollow or cavity of the topologically equivalent molding is accordingly selected such that the volume of the hollow or cavity is in the region of the volume of a hollow or cavity of an annular tablet according to the invention according to the formula V = (D i 2 ·π / 4)·h.
A cuboid-shaped housing for accommodating a plurality of cuboid-shaped accumulators, which are intended as an energy source for the traction drive of motor vehicles, in particular automobiles, the housing having a base wall, first and second circumferential side walls (4, 5) connected thereto and a cover releasably connected to the free ends of the side walls (4, 5), the housing being a sheet metal component bent from a sheet metal plate, the side walls (4, 5) being bent at right angles in the same direction from the base wall and their free ends being bent at right angles outwards, directed away from the housing interior, characterized by that a narrow seam region is folded over in the opposite direction so that a double layer is formed, and that the exposed upper seam region of the double layer is tightly connected to the cover, the cut edge of the seam region lying within the sealed housing region.
A compound of formula I: or a salt or zwitterion thereof, wherein R and R 1 are both H, and R 4 is H or linear or branched C 1 -C 3 alkyl; R 2 and R 3 are independently linear or branched C 1 -C 6 alkyl, or R 2, R 3, together with the carbon to which they are attached, form a C 3 -C 8 cycloalkyl group, which C 3 -C 8 cycloalkyl group is a saturated or partially unsaturated cyclic hydrocarbon group, optionally substituted with linear or branched C 1 -C 6 alkyl; and R 5 is H or linear or branched C 1 -C 6 alkyl optionally substituted with: OH, C(=O)OH, C(=O)NH 2, SH, CH 3 S, HOOCCH(NH 2)CH 2 S-S-CH 2 -, phenyl, hydroxyphenyl, imidazolyl, or indoyl; or R 4 and R 5, together with the atoms to which they are attached, form a pyrrolidine ring optionally substituted with OH. wherein R and R 1 are both H, and R 4 is H or linear or branched C 1 -C 3 alkyl; R 2 and R 3 are independently linear or branched C 1 -C 6 alkyl, or R 2, R 3, together with the carbon to which they are attached, form a C 3 -C 8 cycloalkyl group, which C 3 -C 8 cycloalkyl group is a saturated or partially unsaturated cyclic hydrocarbon group, optionally substituted with linear or branched C 1 -C 6 alkyl; and R 5 is H or linear or branched C 1 -C 6 alkyl optionally substituted with: OH, C(=O)OH, C(=O)NH 2, SH, CH 3 S, HOOCCH(NH 2)CH 2 S-S-CH 2 -, phenyl, hydroxyphenyl, imidazolyl, or indoyl; or R 4 and R 5, together with the atoms to which they are attached, form a pyrrolidine ring optionally substituted with OH. R 4 and R 5, together with the atoms to which they are attached, form a pyrrolidine ring optionally substituted with OH.
A nose-wheel steering system, comprising: an actuator; a strut; and characterized by: a gearing mechanism operably coupling the actuator to the strut, the gearing mechanism including a steering collar attached to the strut, and idler gear engaged with the actuator and a pinion having a first gear engaged with the idler gear and a second gear engaged with the steering collar. an actuator; a strut; and characterized by: a gearing mechanism operably coupling the actuator to the strut, the gearing mechanism including a steering collar attached to the strut, and idler gear engaged with the actuator and a pinion having a first gear engaged with the idler gear and a second gear engaged with the steering collar.
An air conditioning method for a vehicle, comprising: determining an ambient temperature inside the vehicle; determining an operating state of a temperature regulation unit and a minimum air volume of an odor regulation unit in the operating state, wherein the minimum air volume of the odor regulation unit is a flow formed by a rotational speed overcoming a back pressure to ensure that a fragrance is blowable out; receiving a setting of an intensity level of the odor regulation unit; and determining an air volume of the odor regulation unit according to the ambient temperature, the operating state, the minimum air volume, and the intensity level. determining an ambient temperature inside the vehicle; determining an operating state of a temperature regulation unit and a minimum air volume of an odor regulation unit in the operating state, wherein the minimum air volume of the odor regulation unit is a flow formed by a rotational speed overcoming a back pressure to ensure that a fragrance is blowable out; receiving a setting of an intensity level of the odor regulation unit; and determining an air volume of the odor regulation unit according to the ambient temperature, the operating state, the minimum air volume, and the intensity level.
A delivery device for use in administering a dry powder to a biological subject's airway, the device comprising: a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; b) a container, for storing a dose of a dry powder, engaged with the housing and covering an opening therein, the opening located between the inlet and the outlet; c) one or more cantilever structures located within the housing and the free ends thereof spaced from the opening of the housing; d) a deagglomerating surface having a single or plurality of openings, the deagglomerating surface located adjacent the one or more cantilever structures and on an opposite side of the one or more cantilever structures to the opening in the housing such that, in use, the one or more cantilever structures vibrate against or in close proximity to the deagglomerating surface; and e) one or more eddy generating structures located on an opposite side of the deagglomerating surface to the one or more cantilever structures and adjacent the single or plurality of openings of the deagglomerating surface, wherein vibration of the one or more cantilever structures, caused by the flow of gas, forces the dry powder between the one or more cantilever structures and the deagglomerating surface, thereby at least partially deagglomerating the dry powder and allowing the powder to pass through the single or plurality of openings in the deagglomerating surface, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; b) a container, for storing a dose of a dry powder, engaged with the housing and covering an opening therein, the opening located between the inlet and the outlet; c) one or more cantilever structures located within the housing and the free ends thereof spaced from the opening of the housing; d) a deagglomerating surface having a single or plurality of openings, the deagglomerating surface located adjacent the one or more cantilever structures and on an opposite side of the one or more cantilever structures to the opening in the housing such that, in use, the one or more cantilever structures vibrate against or in close proximity to the deagglomerating surface; and e) one or more eddy generating structures located on an opposite side of the deagglomerating surface to the one or more cantilever structures and adjacent the single or plurality of openings of the deagglomerating surface,
A tool with an internal combustion engine, which tool is intended for manual starting, without a starter battery, and which tool comprises an electronic control circuit to control the internal combustion engine and a stop button to stop said internal combustion engine, a connection being arranged between the stop button and said electronic control circuit, c h a r act e r is e d in that said connection between the stop button and the control circuit is arranged to be used for data communications between the control circuit and an external computer.
A package for pharmaceutical products (2, 5), in particular for parenteral products (2, 5), comprising a supporting body forming at least one compartment for containing a pharmaceutical product (2, 5), the supporting body being made from a single-sheet blank, preferably made of paper-based material, which has a base face, an upper face and a plurality of lateral faces which are connected to the base face and/or to the upper face, the upper face having at least one opening, forming the compartments, in it and comprising at least one tab forming a foldable portion defined by cutting lines of the upper face and/or by crease lines, the package being characterised in that the at least one foldable portion delimits the opening, said foldable portion comprising a recess forming a cavity designed to receive the parenteral product (2, 5) to removably constrain the pharmaceutical product (2, 5) to the supporting body, the cavity is formed by a portion of the edges of the opening, the supporting body being able to switch, by moving the base and upper faces (6,7) away from each other, between a non-operating condition in which it has a planar profile which minimises its dimensions and the foldable portion is coplanar with the upper face, and an operating condition in which: - the supporting body is substantially box-shaped; - the foldable portion is folded inside the supporting body so that together with the opening it forms the compartment for containing the pharmaceutical product (2, 5) and the cavity allows, in said operating condition, to removably constrain the parenteral product (2, 5) in the containment compartment in a condition where the parenteral product (2,5) is suspended relative to the base wall within the cavity defined by the foldable portion, - the base face and the upper face are connected to each other by two lateral walls extending, in the operating condition, perpendicularly to the base and upper faces (6, 7) and the package having also two end faces, opposite each other and extending at the ends of the lateral walls, the upper face, the base face, the lateral walls and end faces being defined by crease lines, the tab forming a load-bearing structure of the supporting body. - the supporting body is substantially box-shaped; - the foldable portion is folded inside the supporting body so that together with the opening it forms the compartment for containing the pharmaceutical product (2, 5) and the cavity allows, in said operating condition, to removably constrain the parenteral product (2, 5) in the containment compartment in a condition where the parenteral product (2,5) is suspended relative to the base wall within the cavity defined by the foldable portion, - the base face and the upper face are connected to each other by two lateral walls extending, in the operating condition, perpendicularly to the base and upper faces (6, 7) and the package having also two end faces, opposite each other and extending at the ends of the lateral walls, the upper face, the base face, the lateral walls and end faces being defined by crease lines, the tab forming a load-bearing structure of the supporting body.
A process for the preparation of a compound of formula, which is aripiprazole lauroxil, which comprises the steps of: a) preparation a compound of formula by reacting a compound of formula which is aripiprazol, or a hydrate thereof, with paraformaldehyde in the presence of a suitable organic solvent and a suitable base, wherein the reaction is carried out either in the absence of water or in the presence of a content of water which comes from either the use of a non-anhydrous organic solvent, non-anhydrous reactants, or the use of a hydrated form of aripiprazole, without addition of further water; and b) subsequently converting the compound of formula into aripiprazole lauroxil. a) preparation a compound of formula by reacting a compound of formula which is aripiprazol, or a hydrate thereof, with paraformaldehyde in the presence of a suitable organic solvent and a suitable base, wherein the reaction is carried out either in the absence of water or in the presence of a content of water which comes from either the use of a non-anhydrous organic solvent, non-anhydrous reactants, or the use of a hydrated form of aripiprazole, without addition of further water; and b) subsequently converting the compound of formula into aripiprazole lauroxil.
Silage additive comprising: a. 40 to 90 wt.% nitrite, b. 10 to 60 wt.% ammonium or sodium formate, characterized in that it comprises less than 2 wt.% of hexamethylene tetramine. a. 40 to 90 wt.% nitrite, b. 10 to 60 wt.% ammonium or sodium formate,
A method for reducing the optical reflectivity of a copper and copper alloy circuitry by depositing thereon a metal layer of palladium or palladium alloy comprising, in this order, the steps of (i) providing a dielectric substrate, (ii)depositing copper or a copper alloy onto said dielectric substrate with the proviso that said dielectric substrate comprises a plating base when copper or a copper alloy is deposited by electroless (autocatalytic) plating or electroplating, and (iii) depositing a palladium or palladium alloy layer onto said copper or copper alloy by immersion-type plating and thereby reducing the optical reflectivity of said copper or copper alloy and wherein the copper or copper alloy deposited in step (ii) is structured to form a circuitry either before step (iii) or after step (iii), and wherein the palladium or palladium alloy is deposited in step (iii) from an aqueous plating bath comprising a source for palladium ions, an acid and at least one phosphonate compound. (i) providing a dielectric substrate, (ii)depositing copper or a copper alloy onto said dielectric substrate with the proviso that said dielectric substrate comprises a plating base when copper or a copper alloy is deposited by electroless (autocatalytic) plating or electroplating, and (iii) depositing a palladium or palladium alloy layer onto said copper or copper alloy by immersion-type plating and thereby reducing the optical reflectivity of said copper or copper alloy
Disc brake, in particular for utility vehicles, comprising a brake disc, a brake shaft, of which the axis of rotation is located parallel to a main plane of the brake disc, a brake caliper, in particular a sliding caliper, on which the brake shaft is supported when actuated via a sliding block (18, 20), a brake pad, located on the same side as the brake shaft with respect to the brake disc, a pressure piece between the brake shaft and the brake pad, a first restricting device (52, 54; 56, 58), which restricts the displaceability of the pressure piece with respect to the brake disc in the direction parallel to the axis of rotation of the brake shaft to a predetermined first dimension, and a second restricting device (40, 44, 46; 42, 48, 50), which restricts the displaceability of the brake shaft with respect to the brake disc in the direction parallel to the axis of rotation of the brake shaft to a predetermined second dimension, wherein the brake shaft, when actuated, presses the pressure piece and therefore the brake pad against the brake disc, the second restricting device (40, 44, 46; 42, 48, 50) has a first stop on the pressure piece and a second stop on the brake shaft, which interacts with the first stop with the effect of restricting the displaceability, a third restricting device (22, 24; 26, 28) is provided, which restricts the displaceability of the sliding block (18, 20) with respect to the brake disc in at least one direction located parallel to the main plane of the brake disc to a predetermined third dimension, and the third restricting device (22, 24; 26, 28) has a projection (22, 24) which, when assembled, projects into a recess (26; 28), characterized in that the recess (26; 28) is a blind hole.
A method of monitoring an evacuation system of an aircraft, comprising: receiving, by a processor, a pressure data including a current pressure reading of a pressure cylinder assembly from a digital pressure sensor; receiving, by the processor, a first time a power supply is turned on or a second time the power supply is reset; determining, by the processor, a total in-service time of the pressure cylinder assembly from the first time or the second time; comparing the total in-service time to a service threshold; and generating (512,516,518), by the processor, an alert selected from a group consisting of service due now, service due soon, and evacuation system ready; displaying, in real-time during operation of the aircraft, the pressure data on a customer device, the customer device being in electronic communication with the processor via a network, and the customer device being capable of receiving data over the network and allowing a user to transmit a request to view pressure cylinder assembly data. receiving, by a processor, a pressure data including a current pressure reading of a pressure cylinder assembly from a digital pressure sensor; receiving, by the processor, a first time a power supply is turned on or a second time the power supply is reset; determining, by the processor, a total in-service time of the pressure cylinder assembly from the first time or the second time; comparing the total in-service time to a service threshold; and generating (512,516,518), by the processor, an alert selected from a group consisting of service due now, service due soon, and evacuation system ready; displaying, in real-time during operation of the aircraft, the pressure data on a customer device, the customer device being in electronic communication with the processor via a network, and the customer device being capable of receiving data over the network and allowing a user to transmit a request to view pressure cylinder assembly data.