A compound of Series C-2 or a pharmaceutically acceptable salt thereof that inhibits at least 60 percent of the FITC-labeled naloxone binding when present at a 10 μM concentration and using unlabeled naloxone as the control inhibitor at the same concentration, for use in inhibiting phosphorylation of the tau protein in a method of treating chronic traumatic encephalopathy, wherein said method comprises administering said compound or pharmaceutically acceptable salt thereof in the absence of a mu opioid receptor- (MOR-) binding effective amount of a separate MOR agonist or antagonist, and wherein the compound of Series C-2 is described by the Formula I below: wherein Q is CHR 9 or C, Z is CHR 10 or C, and only one of Q and Z is C; each of m, n and p is zero or one and the sum of m+n+p is 2 or 3; W is selected from the group consisting of NR 20, NR 2, NR 7, S and O, where R 7 and R 2 are the same or different and are H, C v h where each of v and h is 0, 1, 2 or 3 and v+h = 3, C q r -aliphatic C 1 -C 11 hydrocarbyl where each of q and r is 0, 1, or 2 and q+r = 0, 1 or 2, aliphatic C 1 -C 12 hydrocarbyl sulfonyl or aliphatic C 1 -C 12 hydrocarboyl, and R 20 is X- circle A -R 1 as defined hereinafter; J and F are the same or different and are CH 2, CHD or CD 2 (where D is deuterium) X is SO 2, C, CH 2, CD 2, OC, NHC, NHC or NHC; circle A is an aromatic or heteroaromatic ring system that contains a single ring or two fused rings; R 1 is H or represents up to three substituents, R 1a, R 1b, and R 1c, that themselves can be the same or different, wherein each of those three groups, R 1a-c, is separately selected from the group consisting of H, C 1 -C 6 hydrocarbyl, C 1 -C 6 hydrocarbyloxy, C 1 -C 6 hydrocarbyloxycarbonyl, trifluoromethyl, trifluoromethoxy, C 1 -C 7 hydrocarboyl, hydroxy-, trifluoromethyl- or halogen-substituted C 1 -C 7 hydrocarboyl, C 1 -C 6 hydrocarbylsulfonyl, C 1 -C 6 hydrocarbyloxysulfonyl, halogen, nitro, phenyl, cyano, carboxyl, C 1 -C 7 hydrocarbyl carboxylate, carboxamide or sulfonamide, wherein the amido nitrogen in either amide group has the formula NR 3 R 4 in which R 3 and R 4 are the same or different and are H, C 1 -C 4 hydrocarbyl, or R 3 and R 4 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur, M Ar, where M is -CH 2 -, -O- or -N=N- and Ar is a single-ringed aryl or heteroaryl group and NR 5 R 6 wherein R 5 and R 6 are the same or different and are H, C 1 -C 4 hydrocarbyl, C 1 -C 4 acyl, C 1 -C 4 hydrocarbylsulfonyl, or R 5 and R 6 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur. R 8, R 9, and R 10 are each H, or two of R 8, R 9, and R 10 are H and one is a C 1 -C 8 hydrocarbyl group that is unsubstituted or is substituted with up to three atoms that are the same or different and are oxygen or nitrogen atoms. Q is CHR 9 or C, Z is CHR 10 or C, and only one of Q and Z is C; each of m, n and p is zero or one and the sum of m+n+p is 2 or 3; W is selected from the group consisting of NR 20, NR 2, NR 7, S and O, where R 7 and R 2 are the same or different and are H, C v h where each of v and h is 0, 1, 2 or 3 and v+h = 3, C q r -aliphatic C 1 -C 11 hydrocarbyl where each of q and r is 0, 1, or 2 and q+r = 0, 1 or 2, aliphatic C 1 -C 12 hydrocarbyl sulfonyl or aliphatic C 1 -C 12 hydrocarboyl, and R 20 is X- circle A -R 1 as defined hereinafter; J and F are the same or different and are CH 2, CHD or CD 2 (where D is deuterium) X is SO 2, C, CH 2, CD 2, OC, NHC, NHC or NHC; circle A is an aromatic or heteroaromatic ring system that contains a single ring or two fused rings; R 1 is H or represents up to three substituents, R 1a, R 1b, and R 1c, that themselves can be the same or different, wherein each of those three groups, R 1a-c, is separately selected from the group consisting of H, C 1 -C 6 hydrocarbyl, C 1 -C 6 hydrocarbyloxy, C 1 -C 6 hydrocarbyloxycarbonyl, trifluoromethyl, trifluoromethoxy, C 1 -C 7 hydrocarboyl, hydroxy-, trifluoromethyl- or halogen-substituted C 1 -C 7 hydrocarboyl, C 1 -C 6 hydrocarbylsulfonyl, C 1 -C 6 hydrocarbyloxysulfonyl, halogen, nitro, phenyl, cyano, carboxyl, C 1 -C 7 hydrocarbyl carboxylate, carboxamide or sulfonamide, wherein the amido nitrogen in either amide group has the formula NR 3 R 4 in which R 3 and R 4 are the same or different and are H, C 1 -C 4 hydrocarbyl, or R 3 and R 4 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur, M Ar, where M is -CH 2 -, -O- or -N=N- and Ar is a single-ringed aryl or heteroaryl group and NR 5 R 6 wherein R 5 and R 6 are the same or different and are H, C 1 -C 4 hydrocarbyl, C 1 -C 4 acyl, C 1 -C 4 hydrocarbylsulfonyl, or R 5 and R 6 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur. R 8, R 9, and R 10 are each H, or two of R 8, R 9, and R 10 are H and one is a C 1 -C 8 hydrocarbyl group that is unsubstituted or is substituted with up to three atoms that are the same or different and are oxygen or nitrogen atoms.