A system, comprising: a wellhead housing; a tubing hanger disposed within the wellhead housing, the tubing hanger comprising a vertical axis; a hanger running tool; and a hanger locking assembly configured to lock the hanger within the wellhead housing, the hanger locking assembly comprising: an energizing ring comprising one or more axially-extending passageways configured to receive one or more control lines extending from a first axial location above the energizing ring to a second axial location below the energizing ring; an anti-rotation element extending between the energizing ring and the hanger, wherein the anti-rotation element is configured to block rotational movement of the energizing ring relative to the hanger; a locking ring supported by an upper surface of the hanger and in contact with the energizing ring, wherein axial movement of the energizing ring relative to the hanger is configured to drive the locking ring radially between a disengaged position in which the locking ring does not contact the wellhead housing and an engaged position in which the locking ring extends into a corresponding recess of the wellhead housing to block axial movement of the hanger relative to the wellhead; and a retainer ring having a radially inner surface threadably coupled to a radially-outer surface of the hanger and a radially outer surface coupled to the hanger running tool; wherein rotation of the hanger running tool relative to the hanger causes rotation of the retainer ring about threads on the radially-outer surface of the hanger, thereby moving the retainer ring axially downward so that an axially facing surface of the retainer ring contacts or engage an axially-facing surface of the energizing ring causing the energizing ring to move axially downward relative to the hanger to drive the locking ring into the engaged position. a wellhead housing; a tubing hanger disposed within the wellhead housing, the tubing hanger comprising a vertical axis; a hanger running tool; and a hanger locking assembly configured to lock the hanger within the wellhead housing, the hanger locking assembly comprising: an energizing ring comprising one or more axially-extending passageways configured to receive one or more control lines extending from a first axial location above the energizing ring to a second axial location below the energizing ring; an anti-rotation element extending between the energizing ring and the hanger, wherein the anti-rotation element is configured to block rotational movement of the energizing ring relative to the hanger; a locking ring supported by an upper surface of the hanger and in contact with the energizing ring, wherein axial movement of the energizing ring relative to the hanger is configured to drive the locking ring radially between a disengaged position in which the locking ring does not contact the wellhead housing and an engaged position in which the locking ring extends into a corresponding recess of the wellhead housing to block axial movement of the hanger relative to the wellhead; and an energizing ring comprising one or more axially-extending passageways configured to receive one or more control lines extending from a first axial location above the energizing ring to a second axial location below the energizing ring; an anti-rotation element extending between the energizing ring and the hanger, wherein the anti-rotation element is configured to block rotational movement of the energizing ring relative to the hanger; a locking ring supported by an upper surface of the hanger and in contact with the energizing ring, wherein axial movement of the energizing ring relative to the hanger is configured to drive the locking ring radially between a disengaged position in which the locking ring does not contact the wellhead housing and an engaged position in which the locking ring extends into a corresponding recess of the wellhead housing to block axial movement of the hanger relative to the wellhead; and a retainer ring having a radially inner surface threadably coupled to a radially-outer surface of the hanger and a radially outer surface coupled to the hanger running tool;