A process of making a compound of formula I: the process comprising: a) reducing a carbonyl compound of formula II under asymmetric reduction conditions selected from asymmetric hydrogenation and asymmetric transfer hydrogenation using formic acid/triethylamine or potassium hydroxide/isopropyl alcohol, in the presence of a suitable catalyst, in a suitable solvent, to provide a compound of formula III: b) reacting the compound of formula III with a C 1-5 dialkylcarbamoyl chloride, in a suitable solvent, in the presence of a suitable base, to provide a carbamate of formula IV, wherein R is C 1-5 alkyl: c) reacting the compound of formula IV with a suitable borane, boronic acid or boronic acid ester R 2 -B(YRa)(YRb), in a suitable solvent, in the presence of a suitable base, at a suitable temperature to provide an intermediate of formula V, wherein Y is a bond or oxygen, Ra and Rb are each independently hydrogen, C 1-5 alkyl, C 3-8 cycloalkyl, or Ra and Rb together with the atoms to which they are attached form a ring which is optionally substituted with 1-6 substituents selected from C 1-3 alkyl, C 3-6 cycloalkyl, and C 1-3 alkoxyl: d) reacting the compound of formula V with a methylene equivalent in the presence of a suitable metal-C 1-5 dialkylamide base wherein the metal is lithium, sodium, potassium, calcium or magnesium, in a suitable solvent, in the presence of an oxidizing agent to provide a carboxaldehyde of formula VI: e) reacting the carboxaldehyde of formula VI with hydroxylamine, in a suitable solvent, to provide an oxime of formula VII: and f) reacting the oxime of formula VII with an acid, followed by the reaction with N-chlorosuccinimide and ammonium hydroxide, in a suitable solvent, to provide a carboxamidine of formula I: wherein: R and R 2 are each independently hydrogen, C 1-7 alkyl or C 3-10 carbocycle, with the proviso that both R 1 and R 2 are not simultaneously hydrogen; R 4 is hydrogen, C 1-3 alkyl, halogen or nitrile; and X is halogen. a) reducing a carbonyl compound of formula II under asymmetric reduction conditions selected from asymmetric hydrogenation and asymmetric transfer hydrogenation using formic acid/triethylamine or potassium hydroxide/isopropyl alcohol, in the presence of a suitable catalyst, in a suitable solvent, to provide a compound of formula III: b) reacting the compound of formula III with a C 1-5 dialkylcarbamoyl chloride, in a suitable solvent, in the presence of a suitable base, to provide a carbamate of formula IV, wherein R is C 1-5 alkyl: c) reacting the compound of formula IV with a suitable borane, boronic acid or boronic acid ester R 2 -B(YRa)(YRb), in a suitable solvent, in the presence of a suitable base, at a suitable temperature to provide an intermediate of formula V, wherein Y is a bond or oxygen, Ra and Rb are each independently hydrogen, C 1-5 alkyl, C 3-8 cycloalkyl, or Ra and Rb together with the atoms to which they are attached form a ring which is optionally substituted with 1-6 substituents selected from C 1-3 alkyl, C 3-6 cycloalkyl, and C 1-3 alkoxyl: d) reacting the compound of formula V with a methylene equivalent in the presence of a suitable metal-C 1-5 dialkylamide base wherein the metal is lithium, sodium, potassium, calcium or magnesium, in a suitable solvent, in the presence of an oxidizing agent to provide a carboxaldehyde of formula VI: e) reacting the carboxaldehyde of formula VI with hydroxylamine, in a suitable solvent, to provide an oxime of formula VII: and f) reacting the oxime of formula VII with an acid, followed by the reaction with N-chlorosuccinimide and ammonium hydroxide, in a suitable solvent, to provide a carboxamidine of formula I: wherein: R and R 2 are each independently hydrogen, C 1-7 alkyl or C 3-10 carbocycle, with the proviso that both R 1 and R 2 are not simultaneously hydrogen; R 4 is hydrogen, C 1-3 alkyl, halogen or nitrile; and X is halogen. R and R 2 are each independently hydrogen, C 1-7 alkyl or C 3-10 carbocycle, with the proviso that both R 1 and R 2 are not simultaneously hydrogen; R 4 is hydrogen, C 1-3 alkyl, halogen or nitrile; and X is halogen.