A compound having the following structure: and stereoisomers, esters, solvates, and pharmaceutically acceptable salts thereof, wherein: A is pyridyl, phenyl, quinolinyl, or thienopyrimidinyl, wherein the pyridyl, phenyl, quinolinyl, or thienopyrimidinyl is substituted with 0-5 R 4; R 1a is H, halogen, C 1-4 alkyl, alkoxy or trifluoromethyl; R 1b and R 1c are the same or different and are independently H, halogen, hydroxy, haloC 1 - 4 alkyl, -C 1-6 alkyl-(R 5) p, -O-C 1-6 alkyl-(R 5) p, -C 1-6 alkyl-O-C 1-6 alkyl-(R 5) p, -NR 7 -C 1-6 alkyl-(R 5) p, or -S m -C 1-6 alkyl-(R 5) p; R 1d is Cl, F, methyl, or CF 3; R 2 is -C 1-4 alkyl-(R 5) p; R 2a is phenyl substituted with 0-4 R 3, heteroaryl substituted with 0-4 R 3, aryl-C 1-4 alkyl substituted with 0-4 R 3, or heteroaryl-C 1-4 alkyl substituted with 0-4 R 3, wherein heteroaryl is an aromatic heterocyclic ring of 5-10 members containing at least one heteroatom selected from N, O, and S; R 3 at each occurrence is independently halogen, cyano, halo-C 1-4 alkyl, R 5, -C 1-6 alkyl -(R 5) p, -C 1-6 alkyl-O-C 1-6 alkyl-(R 5) p, -O-C 1-6 alkyl-(R 5) p, -NR 7 -C 1-6 alkyl- p, -S m -C 1-6 alkyl-(R 5) p, -O-C 1 - 6 alkyl-NR 7 -C 1-6 alkyl-(R 5) p, heterocycle-(R 5) p; R 4 at each occurrence is independently halogen, C 1-6 alkyl, haloC 1-4 alkyl, C 1-6 alkoxy, hydroxy, cyano, thioC 1-6 alkyl, -C NR 7 R 8 or 5 member heteroaryl containing at least one heteroatom selected from N, O, and S; R 5 at each occurrence is independently H, hydroxy, -OC -C 1-6 alkyl, -OC O-C 1-6 alkyl, -OC -C 1-6 alkyl-NR 7 R 8, -COOR 6, -C NR 7 R 8, -NR 7 C NR 7 R 8, -S 2 NR 9 R 9, -S m -C 1-4 alkyl, -NR 7 R 8, C 1-6 alkoxy, -O-heterocycle, or heterocycle wherein said heterocycle and said -O-heterocycle are substituted with 0-4 groups selected from halogen, C 1-6 alkyl, C 1-4 haloalkyl, hydroxy, oxo, thio, -NH 2, -S 2 C 1-4 alkyl and -COOH; R 6 at each occurrence is independently H, C 1-4 alkyl, C 1-4 alkyl-O-C -C 1-6 alkyl, or C 1-4 alkyl-O-C -O-C 1-6 alkyl; R 7 at each occurrence is independently H, C 1-4 alkyl, hydroxy, or heterocycle where said heterocycle is substituted with 0-4 groups selected from halogen, C 1-6 alkyl, hydroxy, keto, -NH 2 and -COOH; R 8 at each occurrence is independently H, C 1-4 alkyl, haloC 1-4 alkyl, -C -C 1-4 alkyl, -C -haloC 1-4 alkyl, -S m -haloC 1-4 alkyl or -S m -C 1-4 alkyl; R 9 at each occurrence is independently H, C 1-4 alkyl, or -C C 1-4 alkyl; wherein heterocycle is a 5-7 member monomeric or 7-17 member polycyclic heterocyclic ring that is saturated, unsaturated, or aromatic and that contains 1-4 heteroatoms selected from N, O, and S; m is 0-2; and p at each occurrence is independently 1-3. A is pyridyl, phenyl, quinolinyl, or thienopyrimidinyl, wherein the pyridyl, phenyl, quinolinyl, or thienopyrimidinyl is substituted with 0-5 R 4; R 1a is H, halogen, C 1-4 alkyl, alkoxy or trifluoromethyl; R 1b and R 1c are the same or different and are independently H, halogen, hydroxy, haloC 1 - 4 alkyl, -C 1-6 alkyl-(R 5) p, -O-C 1-6 alkyl-(R 5) p, -C 1-6 alkyl-O-C 1-6 alkyl-(R 5) p, -NR 7 -C 1-6 alkyl-(R 5) p, or -S m -C 1-6 alkyl-(R 5) p; R 1d is Cl, F, methyl, or CF 3; R 2 is -C 1-4 alkyl-(R 5) p; R 2a is phenyl substituted with 0-4 R 3, heteroaryl substituted with 0-4 R 3, aryl-C 1-4 alkyl substituted with 0-4 R 3, or heteroaryl-C 1-4 alkyl substituted with 0-4 R 3, wherein heteroaryl is an aromatic heterocyclic ring of 5-10 members containing at least one heteroatom selected from N, O, and S; R 3 at each occurrence is independently halogen, cyano, halo-C 1-4 alkyl, R 5, -C 1-6 alkyl -(R 5) p, -C 1-6 alkyl-O-C 1-6 alkyl-(R 5) p, -O-C 1-6 alkyl-(R 5) p, -NR 7 -C 1-6 alkyl- p, -S m -C 1-6 alkyl-(R 5) p, -O-C 1 - 6 alkyl-NR 7 -C 1-6 alkyl-(R 5) p, heterocycle-(R 5) p; R 4 at each occurrence is independently halogen, C 1-6 alkyl, haloC 1-4 alkyl, C 1-6 alkoxy, hydroxy, cyano, thioC 1-6 alkyl, -C NR 7 R 8 or 5 member heteroaryl containing at least one heteroatom selected from N, O, and S; R 5 at each occurrence is independently H, hydroxy, -OC -C 1-6 alkyl, -OC O-C 1-6 alkyl, -OC -C 1-6 alkyl-NR 7 R 8, -COOR 6, -C NR 7 R 8, -NR 7 C NR 7 R 8, -S 2 NR 9 R 9, -S m -C 1-4 alkyl, -NR 7 R 8, C 1-6 alkoxy, -O-heterocycle, or heterocycle wherein said heterocycle and said -O-heterocycle are substituted with 0-4 groups selected from halogen, C 1-6 alkyl, C 1-4 haloalkyl, hydroxy, oxo, thio, -NH 2, -S 2 C 1-4 alkyl and -COOH; R 6 at each occurrence is independently H, C 1-4 alkyl, C 1-4 alkyl-O-C -C 1-6 alkyl, or C 1-4 alkyl-O-C -O-C 1-6 alkyl; R 7 at each occurrence is independently H, C 1-4 alkyl, hydroxy, or heterocycle where said heterocycle is substituted with 0-4 groups selected from halogen, C 1-6 alkyl, hydroxy, keto, -NH 2 and -COOH; R 8 at each occurrence is independently H, C 1-4 alkyl, haloC 1-4 alkyl, -C -C 1-4 alkyl, -C -haloC 1-4 alkyl, -S m -haloC 1-4 alkyl or -S m -C 1-4 alkyl; R 9 at each occurrence is independently H, C 1-4 alkyl, or -C C 1-4 alkyl; wherein heterocycle is a 5-7 member monomeric or 7-17 member polycyclic heterocyclic ring that is saturated, unsaturated, or aromatic and that contains 1-4 heteroatoms selected from N, O, and S; m is 0-2; and p at each occurrence is independently 1-3.