Method for prognosing and/or diagnosing a type II diabetes mellitus disease of a subject, comprising the steps of: a) determining the gene expression level of the ADIPOQ gene in a sample of the subject and b) classifying the subject into one of at least three risk groups, taking the gene expression level of the ADIPOQ gene into account, wherein the gene expression level of the HMGA2 gene is further taken into account for the classification of the subject in step b), and wherein the groups III) greatly increased relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of increased HbAlc blood values, increased cholesterol values, increased triglycerides, lowered HDL cholesterol, increased non-HDL cholesterol, increased LDL cholesterol, increased CRP, increased blood sugar, increased fasting blood sugar, increased preprandial blood sugar, increased postprandial blood sugar and age ≥ 45, IV) increased relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of nonincreased HbAlc blood values, nonincreased cholesterol values, nonincreased triglycerides, increased HDL cholesterol, nonincreased non-HDL cholesterol, nonincreased LDL cholesterol, nonincreased CRP, nonincreased blood sugar, nonincreased fasting blood sugar, nonincreased preprandial blood sugar, nonincreased postprandial blood sugar and age ≥ 45, and V) lowered relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of nonincreased HbAlc blood values, nonincreased cholesterol values, nonincreased triglycerides, increased HDL cholesterol, nonincreased non-HDL cholesterol, nonincreased LDL cholesterol, nonincreased CRP, nonincreased blood sugar, nonincreased fasting blood sugar, nonincreased preprandial blood sugar, nonincreased postprandial blood sugar and age ≤ 45 are available as possible groups for a classification in step b). a) determining the gene expression level of the ADIPOQ gene in a sample of the subject and b) classifying the subject into one of at least three risk groups, taking the gene expression level of the ADIPOQ gene into account, wherein the gene expression level of the HMGA2 gene is further taken into account for the classification of the subject in step b), and wherein the groups III) greatly increased relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of increased HbAlc blood values, increased cholesterol values, increased triglycerides, lowered HDL cholesterol, increased non-HDL cholesterol, increased LDL cholesterol, increased CRP, increased blood sugar, increased fasting blood sugar, increased preprandial blood sugar, increased postprandial blood sugar and age ≥ 45, IV) increased relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of nonincreased HbAlc blood values, nonincreased cholesterol values, nonincreased triglycerides, increased HDL cholesterol, nonincreased non-HDL cholesterol, nonincreased LDL cholesterol, nonincreased CRP, nonincreased blood sugar, nonincreased fasting blood sugar, nonincreased preprandial blood sugar, nonincreased postprandial blood sugar and age ≥ 45, and V) lowered relative gene expression level for ADIPOQ, lowered relative gene expression level for HMGA2 and also at least one of the marker situations selected from the group consisting of nonincreased HbAlc blood values, nonincreased cholesterol values, nonincreased triglycerides, increased HDL cholesterol, nonincreased non-HDL cholesterol, nonincreased LDL cholesterol, nonincreased CRP, nonincreased blood sugar, nonincreased fasting blood sugar, nonincreased preprandial blood sugar, nonincreased postprandial blood sugar and age ≤ 45 are available as possible groups for a classification in step b).