mhurhangee/ep-ind-claims huggingface dataset:
An oral irrigator comprising a pump mechanism; a reservoir in fluid communication with the pump mechanism; a jet tip in fluid communication with the pump mechanism and configured for directing a fluid pumped from the reservoir by the pump mechanism through the jet tip at a surface inside an oral cavity, the jet tip further comprises a radiant energy conduit having a proximal end and a distal end and the jet tip defines a fluid conduit coaxial with and housing the radiant energy conduit whereby fluid flows through the jet tip in a space between the fluid conduit and the radiant energy conduit; a radiant energy source configured to produce radiant energy and a collimator positioned between the radiant energy source and the radiant energy conduit, the collimator configured to collimate the radiant energy from the radiant energy source and direct the collimated radiant energy at the surface inside the oral cavity; wherein the proximal end of the jet tip is positioned adjacent the collimator source to capture the collimated radiant energy from the collimator and the distal end directs the collimated radiant energy in generally the same direction as the fluid. the proximal end of the jet tip is positioned adjacent the collimator source to capture the collimated radiant energy from the collimator and the distal end directs the collimated radiant energy in generally the same direction as the fluid.
Optical article having a substrate made of an optical material comprising a polymer matrix and at least one organic near infrared absorbing compound incorporated into said matrix, wherein the optical material has the following properties: T VIS is higher than or equal to 75 %, T NIR is lower than or equal to 75 %, in which: T VIS is the average optical transmittance in the 380-780 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material, T NIR is the average optical transmittance in the 780-1400 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material. T VIS is higher than or equal to 75 %, T NIR is lower than or equal to 75 %, in which: T VIS is the average optical transmittance in the 380-780 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material, T NIR is the average optical transmittance in the 780-1400 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material. T VIS is the average optical transmittance in the 380-780 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material, T NIR is the average optical transmittance in the 780-1400 nm wavelength range for the optical material containing said at least one organic near infrared absorbing compound through a 2 mm thick layer of said optical material.
A combination comprising an anti-PD-1 antibody chosen from Nivolumab, Pembrolizumab or Pidilizumab, and LCL161, for use in a method of treating a cancer or a hematopoiesis disorder in a subject, wherein LCL161 is -N-( -1-cyclohexyl-2-( -2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide or a pharmaceutically acceptable salt thereof.
A catheter assembly comprising: a catheter including a proximal catheter portion, a longitudinal axis, a distal catheter portion, and a catheter transition portion between the proximal catheter portion and the distal catheter portion, wherein the longitudinal axis forms a curve, the curve of the longitudinal axis encompassing the proximal catheter portion and the distal catheter portion; and a cannula coupled to the distal catheter portion, the cannula having a proximal cannula portion, a distal cannula portion, and a cannula transition portion comprising a bend between the proximal cannula portion and the distal cannula portion; wherein the cannula is configured such that, when the cannula is inserted in a heart, the distal cannula portion points towards the ventricle apex, the cannula lies within a first plane, and the curve of the longitudinal axis of the catheter and the proximal cannula portion lies in a second plane, wherein the first plane is different from, and at an angular offset relative to the second plane. a catheter including a proximal catheter portion, a longitudinal axis, a distal catheter portion, and a catheter transition portion between the proximal catheter portion and the distal catheter portion, wherein the longitudinal axis forms a curve, the curve of the longitudinal axis encompassing the proximal catheter portion and the distal catheter portion; and a cannula coupled to the distal catheter portion, the cannula having a proximal cannula portion, a distal cannula portion, and a cannula transition portion comprising a bend between the proximal cannula portion and the distal cannula portion; wherein the cannula is configured such that, when the cannula is inserted in a heart, the distal cannula portion points towards the ventricle apex, the cannula lies within a first plane, and the curve of the longitudinal axis of the catheter and the proximal cannula portion lies in a second plane, wherein the first plane is different from, and at an angular offset relative to the second plane.
A motor driving control apparatus, comprising: a driving unit configured to drive a motor; and a controller (3100, 3200, 3300) configured to control the driving unit to start regeneration after lapse of a first time period since a second predetermined time period elapsed or gradually increase a regeneration amount, when a state that an acceleration of a vehicle on which the motor is embodied is negative and equal to or less than a first predetermined value (-A1) continues for the second predetermined time period, wherein the controller (3100, 3200, 3300) controls the driving unit to stop or suppress the regeneration when a state that the acceleration of the vehicle is equal to or greater than a second predetermined value (-A2) continues for a third predetermined time period, after instructing the driving unit to start the regeneration, and characterised in that the second predetermined value (-A2) is a negative value greater than the first predetermined value (-A1) to detect an end of a braking operation, and the second predetermined time period is longer than the third predetermined time period, and the acceleration of the vehicle is a smoothed value. a driving unit configured to drive a motor; and a controller (3100, 3200, 3300) configured to control the driving unit to start regeneration after lapse of a first time period since a second predetermined time period elapsed or gradually increase a regeneration amount, when a state that an acceleration of a vehicle on which the motor is embodied is negative and equal to or less than a first predetermined value (-A1) continues for the second predetermined time period, wherein the controller (3100, 3200, 3300) controls the driving unit to stop or suppress the regeneration when a state that the acceleration of the vehicle is equal to or greater than a second predetermined value (-A2) continues for a third predetermined time period, after instructing the driving unit to start the regeneration, and characterised in that the second predetermined value (-A2) is a negative value greater than the first predetermined value (-A1) to detect an end of a braking operation, and the second predetermined time period is longer than the third predetermined time period, and the acceleration of the vehicle is a smoothed value.
A gear pump, comprising a front plate, a gear plate and a rear plate; a drive shaft having a drive gear; an arbor having a driven gear engaged with the drive gear; first and second bearings (124,126) disposed in the gear plate, the first and second bearings (124,126) each having a first opening for receiving the drive shaft and a second opening for receiving the arbor; wherein the rear plate has first and second drain ports disposed adjacent to respective ends of the drive shaft and the arbor; and wherein the arbor has a longitudinal opening therethrough that runs the full length of the arbor such that pumped media that passes between the first bearing and an outer surface of the arbor in a first direction is directed to the second drain port via the longitudinal opening in a second direction different from the first direction.
A method for diagnosing pancreas cancer in a subject comprising the steps of: (a) determining in a plasma, blood or serum sample of a subject suspected to suffer from pancreas cancer at least the amount of the biomarker Ceramide (d18:1,C24:0) and (b) comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. (a) determining in a plasma, blood or serum sample of a subject suspected to suffer from pancreas cancer at least the amount of the biomarker Ceramide (d18:1,C24:0) and (b) comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed.
An absorber for a tampon, which is generated by compressing and molding a laminate member including a liquid permeable surface member and an absorptive member: wherein the absorptive member before the compression and molding is comprised of: a first region which is a region at a side to be first inserted into a vaginal opening in a case where the absorber for the tampon is divided into two sections in a longitudinal direction; and a second region which is a region at a side to be first removed from the vaginal opening in a case where the absorber for the tampon is divided into two sections in a longitudinal direction; and an area of the first region is smaller than an area of the second region; wherein a width at a side of an insert end part in the first region is 10% to 80% of a width at a side of a removal end part in the second region; wherein a surface shape of the absorptive member before the compression and molding and a planar shape of the surface member are not analogously similar to each other, and a difference between an area of the surface member in the first region and an area of the absorptive member is greater than a difference between an area of the surface member in the second region and an area of the absorptive member.
Apparatus for the decapneization of blood, comprising: - a supply line of the blood to be treated taken from a patient and at least a return line adapted to transport the treated blood to the patient; - at least an oxygenation device and at least a filtering device of the blood positioned between said supply line and said return line; where said supply line comprises a main section, connectable on one side to the patient and connected on the opposite side to said oxygenation device, and a by-pass section, arranged parallel to said main section and along which said filtering device is arranged, characterized by the fact that said by-pass section comprises a delivery branch, connected on one side to said main section and on the other side to the input of said filtering device, and a return branch, connected on one side to the output of the filtering device and on the other side to said main section, and by the fact that it comprises removable connection means, arranged along said branches (6, 7) and adapted to allow the separation of a first portion of the branches themselves which is connected to said filtering device, from a respective second portion connected to said main section, said second portions being connectable to each other by means of the connection means themselves following the separation from their respective first portions. - a supply line of the blood to be treated taken from a patient and at least a return line adapted to transport the treated blood to the patient; - at least an oxygenation device and at least a filtering device of the blood positioned between said supply line and said return line;
An isolated peptide comprising an amino acid segment comprising the amino acid sequence of SEQ ID NO: 1, or the amino acid sequence of SEQ ID NO: 1 having one or more conservative amino acid substitutions, wherein Xaa at position 6 and Xaa at position 15 of SEQ ID NO: 1 have a length of 6, 7, 9 or 10 amino acids, wherein a conservative amino acid substitution is one selected from within the following groupings: Gly, Ala Val, Ile, Met, Leu Asp, Glu Asn, Gln, His Ser, Thr Lys, Arg Phe, Tyr, Trp. Gly, Ala Val, Ile, Met, Leu Asp, Glu Asn, Gln, His Ser, Thr Lys, Arg Phe, Tyr, Trp.
A method of assembling an article of footwear comprising an integral upper portion and sole portion, the method comprising: - providing the article of footwear in an unassembled flat condition and comprising an interior layer and an exterior layer connected to the interior layer, wherein the interior layer and the exterior layer are cut in a pattern forming the integral upper portion and sole portion, the exterior layer comprising an outer material and a structural overlay disposed over the outer material, the structural overlay having an opening exposing a portion of the outer material such that this portion of the outer material is visible, the structural overlay providing a ground engaging portion in the sole portion of the article of footwear, - folding the article of footwear along a midline between the upper portion and the sole portion; and - attaching a top lateral edge of the upper portion to a bottom lateral edge of the sole portion. - providing the article of footwear in an unassembled flat condition and comprising an interior layer and an exterior layer connected to the interior layer, wherein the interior layer and the exterior layer are cut in a pattern forming the integral upper portion and sole portion, the exterior layer comprising an outer material and a structural overlay disposed over the outer material, the structural overlay having an opening exposing a portion of the outer material such that this portion of the outer material is visible, the structural overlay providing a ground engaging portion in the sole portion of the article of footwear, - folding the article of footwear along a midline between the upper portion and the sole portion; and - attaching a top lateral edge of the upper portion to a bottom lateral edge of the sole portion.
A rotational atherectomy device for removing stenotic lesion material from a blood vessel of a patient, the device comprising: an elongate flexible drive shaft comprising a torque-transmitting coil and defining a longitudinal axis, the drive shaft being configured to rotate about the longitudinal axis; first and second abrasive elements attached to a distal end portion of the drive shaft and each having a center of mass offset from the longitudinal axis, the center of mass of the first abrasive element being offset from the longitudinal axis at a first radial angle, the center of mass of the second abrasive element being offset from the longitudinal axis at a second radial angle that differs from the first radial angle, wherein the second radial angle and the first radial angle differ from each other by a relative radial offset in a range of between 5 degrees and about 50 degrees; and characterised in that the drive shaft has a distal stability element fixedly mounted thereto without a proximal stability element located proximal to the abrasive elements, the distal stability element having a center of mass aligned with the longitudinal axis and being distally spaced apart from the first and second abrasive elements, and in that the distal stability element and abrasive elements are configured such that the distal stability element remains in general alignment with the longitudinal axis during rotation of the drive shaft but a portion of the drive shaft adjacent to the abrasive elements orbits around the longitudinal axis. an elongate flexible drive shaft comprising a torque-transmitting coil and defining a longitudinal axis, the drive shaft being configured to rotate about the longitudinal axis; first and second abrasive elements attached to a distal end portion of the drive shaft and each having a center of mass offset from the longitudinal axis, the center of mass of the first abrasive element being offset from the longitudinal axis at a first radial angle, the center of mass of the second abrasive element being offset from the longitudinal axis at a second radial angle that differs from the first radial angle, wherein the second radial angle and the first radial angle differ from each other by a relative radial offset in a range of between 5 degrees and about 50 degrees; and characterised in that the drive shaft has a distal stability element fixedly mounted thereto without a proximal stability element located proximal to the abrasive elements, the distal stability element having a center of mass aligned with the longitudinal axis and being distally spaced apart from the first and second abrasive elements, and in that the distal stability element and abrasive elements are configured such that the distal stability element remains in general alignment with the longitudinal axis during rotation of the drive shaft but a portion of the drive shaft adjacent to the abrasive elements orbits around the longitudinal axis.
A controller for a switched mode power converter module for use in a multiphase switched mode power converter, the controller comprising: a signal generator, configured to generate a periodic signal, having a frequency and a signal phase and for controlling the switched mode power converter module, wherein the signal generator is further configured to generate a clock signal having the frequency and the signal phase; a first-clock input configured to receive a first-clock signal having the frequency and a first phase from a first neighbouring controller; and a second-clock input configured to receive a second-clock signal having the frequency and a second phase from a second neighbouring controller; wherein the signal generator comprises a phase adjustment circuit configured to adjust the phase of the periodic signal so as to be equidistant from the first and second phase, wherein the phase adjustment circuit comprises an error circuit configured to determine an error signal in dependence on an offset between the phase and a mid-point between the first phase and the second phase, and a feedback circuit configured to adjust the phase in dependence on the error signal. a signal generator, configured to generate a periodic signal, having a frequency and a signal phase and for controlling the switched mode power converter module, wherein the signal generator is further configured to generate a clock signal having the frequency and the signal phase; a first-clock input configured to receive a first-clock signal having the frequency and a first phase from a first neighbouring controller; and a second-clock input configured to receive a second-clock signal having the frequency and a second phase from a second neighbouring controller; wherein the signal generator comprises a phase adjustment circuit configured to adjust the phase of the periodic signal so as to be equidistant from the first and second phase, wherein the phase adjustment circuit comprises an error circuit configured to determine an error signal in dependence on an offset between the phase and a mid-point between the first phase and the second phase, and a feedback circuit configured to adjust the phase in dependence on the error signal.
Operating element for a motor vehicle, comprising a housing element; a key cap element which is arranged on the housing element; at least two lever elements arranged in the housing element; at least one switching element which is arranged in a switchable manner between the at least two lever elements and the key cap element, characterized in that the operating element comprises at least one at least partially electrically switchable first functional element, and in that at least one second functional element is arranged on the two lever elements, wherein the at least one at least partially electrically switchable first functional element is operatively connected to the at least one second functional element, wherein a change in state in the at least one first functional element causes a change in state in the at least one second functional element, so that at least one switching element can be switched from a first position to a second position in a user-defined manner by means of at least one of the two lever elements if an external force acts on the key cap element.
A method for assessing the pathological status of a liver in a subject suspected of having a liver pathology comprising: contacting a protein in or from a biological fluid of said subject with a fucose-binding lectin, wherein said protein is IgG, allowing said lectin to bind to said protein, quantifiably detecting said bound lectin in or from the biological fluid to obtain a detected bound lectin value; and comparing the detected bound lectin value with a reference value for bound lectin on said protein in or from a comparable biological fluid of subjects without said liver pathology, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected bound lectin value showing a significant deviation from said reference value is indicative of the presence of said liver pathology, or comparing the detected bound lectin value with a reference value for bound lectin on said protein in or from a comparable biological fluid of subjects in which said liver pathology is known to be present, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected bound lectin value showing a significant deviation from said reference value is indicative of the absence of said liver pathology, and wherein the liver pathology is selected from cirrhosis, hepatocellular carcinoma and fibrosis. contacting a protein in or from a biological fluid of said subject with a fucose-binding lectin, wherein said protein is IgG, allowing said lectin to bind to said protein, quantifiably detecting said bound lectin in or from the biological fluid to obtain a detected bound lectin value; and comparing the detected bound lectin value with a reference value for bound lectin on said protein in or from a comparable biological fluid of subjects without said liver pathology, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected bound lectin value showing a significant deviation from said reference value is indicative of the presence of said liver pathology, or comparing the detected bound lectin value with a reference value for bound lectin on said protein in or from a comparable biological fluid of subjects in which said liver pathology is known to be present, said detected bound lectin value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected bound lectin value showing a significant deviation from said reference value is indicative of the absence of said liver pathology, and wherein the liver pathology is selected from cirrhosis, hepatocellular carcinoma and fibrosis.