A compound according to formula I: wherein X is O or S; R 1 denotes H, Hal, CF 3, OCF 3, CN, or NO 2; R 2 is H, A or Hal; R 8 is H, A, Ar, or Het; provided that R a is not a benzo[1,3]dioxolyl group, or a phenyl group being unsubstituted or substituted by at least one Methyl, F, Cl, OMe and/or OEt, if R b is a methyl group; R b is A, Ar, Het, OA, NHA, or NA 2, Ar-alkyl, or Het-alkyl; Hal is F, Cl, Br or I; A is a branched or linear alkyl having 1 to 12 C-atoms, wherein one or more, preferably 1 to 7 H-atoms may be replaced by Hal, OR 3, CN, CO 2 R 3, cycloalkyl having 3 to 7 ring carbon atoms, or N(R 3) 2 and wherein one or more, preferably 1 to 7 non-adjacent CH 2 -groups may be replaced by O, NR 3 or S and/or by -CO-, -NR 3 CO-, -CONR 3 -, NR 3 CO 2 -, -NR 3 CONR 3 -, -CH=CH-, -C≡C-, groups, or or denotes cycloalkyl or cycloalkylalkylen having 3-7 ring C atoms; q is 1, 2, 3, or 4 Ar denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substitutent selected from R 4 and/or R 5; Ar-alkyl denotes an aryl group linked to the rest of the molecule through a C 1 -C 12 alkylen chain, preferably C 1 -C 6 alkylen chain. Preferred Ar-alkyl are linked to the rest of the molecule through a methylen or a ethylen group. Het denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substitutent selected from R 4 and/or R 5; and wherein one or more CH 2 groups may be replaced by -CO- Het-alkyl denotes a group Het linked to the rest of the molecule through a C 1 -C 12 alkylen chain, preferably C 1 -C 6 alkylen chain. Preferred Het-alkyl are linked to the rest of the molecule through a methylen or a ethylen group. R 4 and R 5 are each independently selected from A, Hal, hydroxy, alkoxy, carboxy, carboxy-alkyl, Perfluoro-alkyl, Perfluoro-alkoxy, acyl, alkylsulfonyl, sulfonyl, -SO 2 (R 3) 2, cyano, nitro, amino, amido, alkyl optionally substituted by a carboxy, -N(R 3) 2, -CO(NR 3) 2, -OR 3, (NR 3)COR 3, -CO 2 R 3, -COR 3, or Ar-alkyl or Het-alkyl both optionally substituted by A, Hal, an acyl, alkylsulfonyl, carboxy, -N(R 3) 2, -CON(R 3) 2, -OR 3, (NR 3)COR 3,-CO 2 R 3, -COR 3, -SO 2 N(R 3) 2, -SO 2 alkyl, NR 3 SO 2 alkyl, NR 3 SO 2 alkyl, or C 1 -C 6 alkyl; R 3 is H or A; and pharmaceutically acceptable solvates, tautomers, salts and stereoisomers thereof, including mixtures thereof in all ratios. X is O or S; R 1 denotes H, Hal, CF 3, OCF 3, CN, or NO 2; R 2 is H, A or Hal; R 8 is H, A, Ar, or Het; provided that R a is not a benzo[1,3]dioxolyl group, or a phenyl group being unsubstituted or substituted by at least one Methyl, F, Cl, OMe and/or OEt, if R b is a methyl group; R b is A, Ar, Het, OA, NHA, or NA 2, Ar-alkyl, or Het-alkyl; Hal is F, Cl, Br or I; A is a branched or linear alkyl having 1 to 12 C-atoms, wherein one or more, preferably 1 to 7 H-atoms may be replaced by Hal, OR 3, CN, CO 2 R 3, cycloalkyl having 3 to 7 ring carbon atoms, or N(R 3) 2 and wherein one or more, preferably 1 to 7 non-adjacent CH 2 -groups may be replaced by O, NR 3 or S and/or by -CO-, -NR 3 CO-, -CONR 3 -, NR 3 CO 2 -, -NR 3 CONR 3 -, -CH=CH-, -C≡C-, groups, or or denotes cycloalkyl or cycloalkylalkylen having 3-7 ring C atoms; q is 1, 2, 3, or 4 Ar denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substitutent selected from R 4 and/or R 5; Ar-alkyl denotes an aryl group linked to the rest of the molecule through a C 1 -C 12 alkylen chain, preferably C 1 -C 6 alkylen chain. Preferred Ar-alkyl are linked to the rest of the molecule through a methylen or a ethylen group. Het denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic ring having 1 to 4 N, O and/or S atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by a substitutent selected from R 4 and/or R 5; and wherein one or more CH 2 groups may be replaced by -CO- Het-alkyl denotes a group Het linked to the rest of the molecule through a C 1 -C 12 alkylen chain, preferably C 1 -C 6 alkylen chain. Preferred Het-alkyl are linked to the rest of the molecule through a methylen or a ethylen group. R 4 and R 5 are each independently selected from A, Hal, hydroxy, alkoxy, carboxy, carboxy-alkyl, Perfluoro-alkyl, Perfluoro-alkoxy, acyl, alkylsulfonyl, sulfonyl, -SO 2 (R 3) 2, cyano, nitro, amino, amido, alkyl optionally substituted by a carboxy, -N(R 3) 2, -CO(NR 3) 2, -OR 3, (NR 3)COR 3, -CO 2 R 3, -COR 3, or Ar-alkyl or Het-alkyl both optionally substituted by A, Hal, an acyl, alkylsulfonyl, carboxy, -N(R 3) 2, -CON(R 3) 2, -OR 3, (NR 3)COR 3,-CO 2 R 3, -COR 3, -SO 2 N(R 3) 2, -SO 2 alkyl, NR 3 SO 2 alkyl, NR 3 SO 2 alkyl, or C 1 -C 6 alkyl; R 3 is H or A;