mhurhangee/ep-ind-claims huggingface dataset:
A prefilled syringe containing a stable liquid pharmaceutical formulation, wherein the liquid pharmaceutical formulation comprises: (i) a human antibody that specifically binds to human interleukin-4 receptor alpha (hIL-4Rα) at a concentration up to 200 mg/ml, wherein said human antibody that specifically binds to hIL-4R consists of two heavy chains and two light chains, each heavy chain comprising a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 1 and a heavy chain constant region comprising domains CH1, CH2 and CH3, and each light chain comprising a light chain variable region (LCVR) comprising the amino acid sequence SEQ ID NO:5 and a light chain constant region; (ii) acetate at a concentration of 12.5 mM ± 2 mM; (iii) histidine at a concentration of 20 mM ± 3 mM; (iv) sucrose at a concentration of 5% w/v ± 0.75% w/v; (v) polysorbate 20 or polysorbate 80 at a concentration of 0.2% w/v ± 0.03% w/v; and (vi) arginine at a concentration of 25 mM ± 3.75 mM or at a concentration of 50 mM ± 7.5 mM; wherein the formulation has a pH of 5.6 to 6.2, and wherein at least 90% of the native form of the antibody is recovered after six months of storage at 5°C, as determined by size exclusion chromatography. (i) a human antibody that specifically binds to human interleukin-4 receptor alpha (hIL-4Rα) at a concentration up to 200 mg/ml, wherein said human antibody that specifically binds to hIL-4R consists of two heavy chains and two light chains, each heavy chain comprising a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 1 and a heavy chain constant region comprising domains CH1, CH2 and CH3, and each light chain comprising a light chain variable region (LCVR) comprising the amino acid sequence SEQ ID NO:5 and a light chain constant region; (ii) acetate at a concentration of 12.5 mM ± 2 mM; (iii) histidine at a concentration of 20 mM ± 3 mM; (iv) sucrose at a concentration of 5% w/v ± 0.75% w/v; (v) polysorbate 20 or polysorbate 80 at a concentration of 0.2% w/v ± 0.03% w/v; and (vi) arginine at a concentration of 25 mM ± 3.75 mM or at a concentration of 50 mM ± 7.5 mM;
A process of foaming a polyurethane foam comprising mixing polyurethane foam forming components with a foam blowing agent comprising 2,4,4,4-tetrafluorobutene-1.
A laser system, comprising: a plurality of laser modules to drive light through an optical fiber that exits the system; a rack including a stack of slots to support the laser modules in first positions within the rack, wherein the rack comprises a pair of struts extending at opposite sides of an opening in the rack through which the laser modules may pass; characterized by an indexable module service shelf (300, 400) attachable to discrete attachment points on the struts that are indexed at a respective height of each of the slots, to support a weight of one of the laser modules, when passed from the first position and through the opening to a second position that is cantilevered external from the rack, and in alignment with the opening and at the respective height of one of the slots associated with the first position, and wherein the module service shelf (300, 400) comprises a plurality of detachable sections (306, 308, 310). a plurality of laser modules to drive light through an optical fiber that exits the system; a rack including a stack of slots to support the laser modules in first positions within the rack, wherein the rack comprises a pair of struts extending at opposite sides of an opening in the rack through which the laser modules may pass; characterized by an indexable module service shelf (300, 400) attachable to discrete attachment points on the struts that are indexed at a respective height of each of the slots, to support a weight of one of the laser modules, when passed from the first position and through the opening to a second position that is cantilevered external from the rack, and in alignment with the opening and at the respective height of one of the slots associated with the first position, and wherein the module service shelf (300, 400) comprises a plurality of detachable sections (306, 308, 310).
A measurement method of measuring a volume of a drug filled in a needle-like recess of a mold in which a plurality of needle-like recesses that are inverted types of a micro-needle are formed, said micro-needles being provided at a skin patch having a micro-needle array, the measurement method comprising: a measurement wave intensity acquisition step of acquiring, for each needle-like recess, an intensity of a measurement wave transmitted through the drug in the needle-like recess, absorbed by the drug by an amount according to a distance by which the measurement wave is transmitted through the drug, and emitted from the drug; a volume acquisition step of acquiring the volume for each needle-like recess on the basis of the intensity of the measurement wave for each needle-like recess acquired in the measurement wave intensity acquisition step, wherein the volume acquisition step includes acquiring a total volume of the volume of the drug filled in the mold from the volume of the drug of each needle-like recess. a measurement wave intensity acquisition step of acquiring, for each needle-like recess, an intensity of a measurement wave transmitted through the drug in the needle-like recess, absorbed by the drug by an amount according to a distance by which the measurement wave is transmitted through the drug, and emitted from the drug; a volume acquisition step of acquiring the volume for each needle-like recess on the basis of the intensity of the measurement wave for each needle-like recess acquired in the measurement wave intensity acquisition step, wherein the volume acquisition step includes acquiring a total volume of the volume of the drug filled in the mold from the volume of the drug of each needle-like recess.
Polyamide comprising the repeating unit of formula I below: in which o A represents a covalent bond or a divalent hydrocarbon-based group chosen from saturated or unsaturated aliphatics, saturated or unsaturated cycloaliphatics, aromatics comprising at least 5 carbon atoms, arylaliphatics and alkylaromatics; o X represents a divalent group of formula II or III below: o A represents a covalent bond or a divalent hydrocarbon-based group chosen from saturated or unsaturated aliphatics, saturated or unsaturated cycloaliphatics, aromatics comprising at least 5 carbon atoms, arylaliphatics and alkylaromatics; o X represents a divalent group of formula II or III below:
A communication data processing method, performed by a terminal device, the method comprising: detecting an actual transmission rate between the terminal device and a base station; and in response to the actual transmission rate being less than a preset rate threshold for maintaining a connection between the terminal device and the base station, performing, according to a difference between the actual transmission rate and the preset rate threshold, communication of compensation data with a preset server through the base station, wherein the sum of a transmission rate of the compensation data and the actual transmission rate is greater than or equal to the preset rate threshold, wherein when the actual transmission rate is greater than or equal to the preset rate threshold, the communication of the compensation data with the preset server is stopped. detecting an actual transmission rate between the terminal device and a base station; and in response to the actual transmission rate being less than a preset rate threshold for maintaining a connection between the terminal device and the base station, performing, according to a difference between the actual transmission rate and the preset rate threshold, communication of compensation data with a preset server through the base station, wherein the sum of a transmission rate of the compensation data and the actual transmission rate is greater than or equal to the preset rate threshold, wherein when the actual transmission rate is greater than or equal to the preset rate threshold, the communication of the compensation data with the preset server is stopped.
A helical anchor (72; 150; 160) for docking a prosthetic mitral valve in a native mitral valve, the helical anchor (72; 160) adapted to be received in a coil guide catheter in a straightened configuration and to be delivered from the coil guide catheter, and comprising: a plurality of coils (104, 108; 156; 164a, 164b) having a preformed, coiled configuration after being delivered from the coil guide catheter and adapted to support the prosthetic mitral valve upon being fully delivered form the coil guide catheter and implanted with a first coil portion (108; 164b) above and a second coil portion (104; 164a) below a mitral valve annulus of the native mitral valve, wherein the second coil portion (104; 164a) includes a plurality of coils configured to encircle heart valve leaflets (38, 42) of the native mitral valve, and further comprising a gap between the first coil portion (108; 164b) and the second coil portion (104; 164a) such that the first coil portion (108; 164b) and the second coil portion (104; 164a) do not trap mitral leaflet tissue between the first coil portion (108; 164b) and the second coil portion (104; 164a) upon implantation.
A method of reducing a time required for processing a dough which comprises gluten and which is provided for producing baked goods by speeding-up dough relaxation, the method comprising: a step of exerting mechanical force on the dough; decreasing a resistance of the dough against deformation after or during said step of exerting mechanical force on the dough by applying an electromagnetic field to the dough; another step of exerting mechanical force on the dough after applying the electromagnetic field to the dough; and baking the dough after said other step of exerting mechanical force on the dough; wherein the steps of exerting (28, 32) mechanical force on the dough are selected from a group consisting of kneading, shaping and dividing the dough; wherein the electromagnetic field is applied to the dough for a period of less than 30 s, preferably of less than 15 s, and more preferably of less than 5 s; and wherein the dough rests less than 10 minutes, preferably less than 5 minutes, and more preferably less than 1 minute between the steps of exerting (28, 32) mechanical force on the dough. a step of exerting mechanical force on the dough; decreasing a resistance of the dough against deformation after or during said step of exerting mechanical force on the dough by applying an electromagnetic field to the dough; another step of exerting mechanical force on the dough after applying the electromagnetic field to the dough; and baking the dough after said other step of exerting mechanical force on the dough; wherein the steps of exerting (28, 32) mechanical force on the dough are selected from a group consisting of kneading, shaping and dividing the dough; wherein the electromagnetic field is applied to the dough for a period of less than 30 s, preferably of less than 15 s, and more preferably of less than 5 s; and wherein the dough rests less than 10 minutes, preferably less than 5 minutes, and more preferably less than 1 minute between the steps of exerting (28, 32) mechanical force on the dough.
Use of a slip that comprises zirconium oxide suspended in a liquid medium for the production of ceramic shaped parts by an inkjet printing process, wherein the slip has a zirconium oxide content of 68 to 88 wt %, preferably 70 to 86 wt % and particularly preferably 75 to 85 wt %, and comprises not more than 3 wt %, preferably not more than 2 wt % and particularly preferably not more than 1 wt % of organic components, relative to the total mass of the slip, wherein the zirconium oxide in the slip exhibits a particle size of 50 to 250 nm, measured as the dso value and relative to the volume of the particles, and wherein the slip has a viscosity of 5 to 1000 mPas, measured at a shear rate of from 0.1 to 1000 s -1 and at a temperature of 25 °C.
A composition comprising, based on the total weight of the composition: 65 to 99.95 weight percent of a copolycarbonate comprising first carbonate units derived from a first bisphenol monomer such that a homopolycarbonate of the first bisphenol monomer has a glass transition temperature less than 155 °C determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute, and second carbonate units derived from a second bisphenol monomer such that a homopolycarbonate of the second bisphenol monomer has a glass transition temperature of 155 °C or higher determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute; and 0.05 to 2 weight percent of a roughening agent comprising a particulate crosslinked polymethylsilsesquioxane having a median equivalent spherical diameter greater than 5 micrometers and less than or equal to 10 micrometers determined by laser diffraction according to ISO 13320:2009. 65 to 99.95 weight percent of a copolycarbonate comprising first carbonate units derived from a first bisphenol monomer such that a homopolycarbonate of the first bisphenol monomer has a glass transition temperature less than 155 °C determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute, and second carbonate units derived from a second bisphenol monomer such that a homopolycarbonate of the second bisphenol monomer has a glass transition temperature of 155 °C or higher determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute; and first carbonate units derived from a first bisphenol monomer such that a homopolycarbonate of the first bisphenol monomer has a glass transition temperature less than 155 °C determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute, and second carbonate units derived from a second bisphenol monomer such that a homopolycarbonate of the second bisphenol monomer has a glass transition temperature of 155 °C or higher determined by dynamic mechanical analysis according to ASTM E1640-13 at a heating rate of 1 °C/minute; and 0.05 to 2 weight percent of a roughening agent comprising a particulate crosslinked polymethylsilsesquioxane having a median equivalent spherical diameter greater than 5 micrometers and less than or equal to 10 micrometers determined by laser diffraction according to ISO 13320:2009.
Device for delivering a liquid additive to an exhaust gas treatment system of a motor vehicle, the device having an additive delivery unit and having an electronic unit, wherein the additive delivery unit has at least one hydraulic component for delivering the liquid additive, wherein all of the electrical connections of the at least one hydraulic component are brought together in a first plug connector on the additive delivery unit, characterized in that the electronic unit has a second plug connector which can be connected to the first plug connector, wherein the first plug connector and the second plug connector are connected to one another and form a plug connection when the electronic unit and the additive delivery unit are connected to one another.
A climbing aid for a machine having a continuous track, comprising a base body, which is formed of profile elements (3, 4) connected to one another on a lap joint, wherein the profile elements (3, 4) have a girder section (5, 6), on which a climbing aid profile element (11, 12) is arranged, which protrudes beyond the girder section (5, 6), and wherein the profile elements (3, 4) of the base body are connected to one another in a positively locking manner in the region of the lap joint, characterized in that in order to form the positively locking connection of the profile elements (3, 4), at least one of these profile elements (3, 4) has a recess on the front side and the profile elements (3, 4) are telescoped in the region of this recess.
Data technical system for organizing workflows in which the collaboration of humans and machines is intralogistically controlled with optimal protective effect for the involved humans, with the following features: a) An intralogistically relevant work area is divided into production or storage areas, which are accessible without obstacles via transport areas for the humans and machines involved in the work process, wherein the transport areas are seamlessly data-technically accessible via appropriately distributed radio participants as transmitters and receivers, and an intralogistic process manager system takes over the overall control, b) Numerous driverless transport systems of various designs and manufacturer-specific control subsystems can be used for handling the transport tasks, c) Robots of various designs and manufacturer-specific control subsystems are used for performing the tasks, characterized in that for handling the transport tasks transport drones are used, for performing the tasks humans equipped with radios are also used, wherein the localization of involved humans and machines, whose position within the intralogistically relevant work area is not yet known, is carried out decentrally and in relation to network participants, who have already determined their exact position, using the signal propagation times of electromagnetic waves, without the need for extra surveyed access points, and with the help of the position of individual driverless transport vehicles, from whose own localization systems a separate radio localization is carried out. a) An intralogistically relevant work area is divided into production or storage areas, which are accessible without obstacles via transport areas for the humans and machines involved in the work process, wherein the transport areas are seamlessly data-technically accessible via appropriately distributed radio participants as transmitters and receivers, and an intralogistic process manager system takes over the overall control, b) Numerous driverless transport systems of various designs and manufacturer-specific control subsystems can be used for handling the transport tasks, c) Robots of various designs and manufacturer-specific control subsystems are used for performing the tasks, for handling the transport tasks transport drones are used, for performing the tasks humans equipped with radios are also used, wherein the localization of involved humans and machines, whose position within the intralogistically relevant work area is not yet known, is carried out decentrally and in relation to network participants, who have already determined their exact position, using the signal propagation times of electromagnetic waves, without the need for extra surveyed access points, and with the help of the position of individual driverless transport vehicles, from whose own localization systems a separate radio localization is carried out.
A hyperbranched polyester amide having a cloud point of at least 50°C in demineralised water or in salt solution also referred to as brine, where the polyester amide comprises at least one end group thereon selected from: at least one neutral end group comprising a positively charged cationic moiety preferably an onium ion (more preferably a quaternary ammonium or phosphonium cation) which bears no hydrogen atom covalently attached to a negatively charged moiety such as a carboxylate group which may not be adjacent to the cationic site, wherein the cloud point of the polyester amide is determined following the procedure of weighing in a 50ml glass vial 140mg of the polyester amide to which is added water or a brine solution to a total weight of 20g, and wherein in the case of amine containing polyester amides the pH is adjusted with 5% w/w HCI solution to obtain a pH of 4, a Teflon coated stirrer bar is added to the vial and a thermocouple is immersed in the solution for at least 1 cm, approximately in the middle of the vial, the vial is placed on a stirrer/heater and the temperature is gradually increased while stirring, the solution is observed visually while warming and the cloud point is indicated by the first sign of cloudiness of the solution, wherein for the determination of the cloud point in brine solutions a salt composition was used consisting of 140 g Sodium chloride 30 g Calcium chloride.6H 2 O 8 g Magnesium chloride.6H 2 O dissolved in 1 litre of demineralised water, wherein the pH of the solution was adjusted to 4 with 0.1 M hydrochloric acid solution. at least one neutral end group comprising a positively charged cationic moiety preferably an onium ion (more preferably a quaternary ammonium or phosphonium cation) which bears no hydrogen atom covalently attached to a negatively charged moiety such as a carboxylate group which may not be adjacent to the cationic site, wherein the cloud point of the polyester amide is determined following the procedure of weighing in a 50ml glass vial 140mg of the polyester amide to which is added water or a brine solution to a total weight of 20g, and wherein in the case of amine containing polyester amides the pH is adjusted with 5% w/w HCI solution to obtain a pH of 4, a Teflon coated stirrer bar is added to the vial and a thermocouple is immersed in the solution for at least 1 cm, approximately in the middle of the vial, the vial is placed on a stirrer/heater and the temperature is gradually increased while stirring, the solution is observed visually while warming and the cloud point is indicated by the first sign of cloudiness of the solution, wherein for the determination of the cloud point in brine solutions a salt composition was used consisting of 140 g Sodium chloride 30 g Calcium chloride.6H 2 O 8 g Magnesium chloride.6H 2 O dissolved in 1 litre of demineralised water, wherein the pH of the solution was adjusted to 4 with 0.1 M hydrochloric acid solution. 140 g Sodium chloride 30 g Calcium chloride.6H 2 O 8 g Magnesium chloride.6H 2 O
A light guide assembly for a tomography detector module for a nuclear imaging scanner, including: a plurality of overlapping light guides, with an overlapping structure on each of a first side and a second side of each overlapping light guide; a plurality of underlapping light guides, each having an underlapping structure on each of a first side and a second side of each underlapping light guide; characterized in that the overlapping structures of each of the plurality of overlapping light guides interface with an underlapping structure of each of two of the plurality of underlapping light guides, such that the plurality of overlapping light guides and underlapping light guides are alternately coupled together to form a continuous ring when mounted to a nuclear imaging scanner gantry. a plurality of overlapping light guides, with an overlapping structure on each of a first side and a second side of each overlapping light guide; a plurality of underlapping light guides, each having an underlapping structure on each of a first side and a second side of each underlapping light guide; characterized in that the overlapping structures of each of the plurality of overlapping light guides interface with an underlapping structure of each of two of the plurality of underlapping light guides, such that the plurality of overlapping light guides and underlapping light guides are alternately coupled together to form a continuous ring when mounted to a nuclear imaging scanner gantry.