mhurhangee/ep-ind-claims huggingface dataset:
A method for producing a compound represented by formula comprising reacting a compound represented by formula with a halogenating agent in the presence of a halogen ion source that is soluble in an organic solvent and a deoxidizing agent: wherein, each of R 1 and R 2 independently represents a hydrogen atom, or an unsubstituted or substituted alkyl group, and R 1 and R 2 may form a ring together, A represents a hydroxyl group, a thiol group, an amino group, a nitro group, a halogen atom or an organic group, 1 represents any one of integers of 0 to 3, R 5 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group, an unsubstituted or substituted heteroarylcarbonyl group, an unsubstituted or substituted alkoxycarbonyl group, an unsubstituted or substituted alkylsulfonyl group, or an unsubstituted or substituted arylsulfonyl group, R 6 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group, an unsubstituted or substituted heteroarylcarbonyl group, an unsubstituted or substituted alkoxycarbonyl group, an unsubstituted or substituted alkylsulfonyl group, or an unsubstituted or substituted arylsulfonyl group, and R 5 and R 6 may be bonded to form a ring, X represents a halogen atom, the halogenating agent is at least one selected from the group consisting of thionyl chloride, thionyl bromide, sulfuryl chloride, phosgene, diphosgene, triphosgene, and phosphorus oxychloride, the halogen ion source is a triethylamine hydrohalide salt or a di-i-propylethylamine hydrohalide salt, and the deoxidizing agent is triethylamine or di-i-propylethyl amine. each of R 1 and R 2 independently represents a hydrogen atom, or an unsubstituted or substituted alkyl group, and R 1 and R 2 may form a ring together, A represents a hydroxyl group, a thiol group, an amino group, a nitro group, a halogen atom or an organic group, 1 represents any one of integers of 0 to 3, R 5 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group, an unsubstituted or substituted heteroarylcarbonyl group, an unsubstituted or substituted alkoxycarbonyl group, an unsubstituted or substituted alkylsulfonyl group, or an unsubstituted or substituted arylsulfonyl group, R 6 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group, an unsubstituted or substituted heteroarylcarbonyl group, an unsubstituted or substituted alkoxycarbonyl group, an unsubstituted or substituted alkylsulfonyl group, or an unsubstituted or substituted arylsulfonyl group, and R 5 and R 6 may be bonded to form a ring, X represents a halogen atom, the halogenating agent is at least one selected from the group consisting of thionyl chloride, thionyl bromide, sulfuryl chloride, phosgene, diphosgene, triphosgene, and phosphorus oxychloride, the halogen ion source is a triethylamine hydrohalide salt or a di-i-propylethylamine hydrohalide salt, and the deoxidizing agent is triethylamine or di-i-propylethyl amine.
A signal processing device comprising: a determination unit configured to determine a state of software associated with image processing on an input image signal indicating an image captured by a medical apparatus; wherein the state of the software is determined as being one of normal and not normal; and an output control unit configured to have a first processed image signal resulting from image processing of the input image signal performed by the software selectively outputted, on the basis of a result of determination of the state of the software, where the first processed image signal is outputted when the state of the software is determined to be normal, and is not outputted when the state of the software is determined to be not normal; characterized in that the determination unit causes hardware executing the software to perform a predetermined process, and determines the state of the software on the basis of a result of the predetermined process; and wherein, the hardware has a plurality of processor cores and the determination unit causes at least two of the plurality of processor cores to each perform the predetermined process, and determines the state of the software on the basis of a result of the predetermined process performed in each of the at least two processor cores. a determination unit configured to determine a state of software associated with image processing on an input image signal indicating an image captured by a medical apparatus; wherein the state of the software is determined as being one of normal and not normal; and an output control unit configured to have a first processed image signal resulting from image processing of the input image signal performed by the software selectively outputted, on the basis of a result of determination of the state of the software, where the first processed image signal is outputted when the state of the software is determined to be normal, and is not outputted when the state of the software is determined to be not normal; characterized in that the determination unit causes hardware executing the software to perform a predetermined process, and determines the state of the software on the basis of a result of the predetermined process; and wherein, the hardware has a plurality of processor cores and the determination unit causes at least two of the plurality of processor cores to each perform the predetermined process, and determines the state of the software on the basis of a result of the predetermined process performed in each of the at least two processor cores.
A medical device, which can be moved via a pneumatic system for endoscopic applications, comprising - a shaft, - an endoscope tip which is mounted on one end of the shaft, and characterized by - the shaft which is manufactured from a flexible material and which can elongate, - at least one first chamber comprising a rear wall (3.1) and a front wall (3.2), whereby the first chamber is provided inside the endoscope tip, - at least one cylindrical type balloon which can elongate in the axial direction through the colon as it is inflated, which has an inlet (5.2) connected to one end of the shaft and a closed tip (5.1) disposed in the first chamber, and wherein the balloon enables the endoscope tip to be advanced by pressing on the rear wall (3.1) of the endoscope tip during its inflation. - a shaft, - an endoscope tip which is mounted on one end of the shaft, and characterized by - the shaft which is manufactured from a flexible material and which can elongate, - at least one first chamber comprising a rear wall (3.1) and a front wall (3.2), whereby the first chamber is provided inside the endoscope tip, - at least one cylindrical type balloon which can elongate in the axial direction through the colon as it is inflated, which has an inlet (5.2) connected to one end of the shaft and a closed tip (5.1) disposed in the first chamber, and wherein the balloon enables the endoscope tip to be advanced by pressing on the rear wall (3.1) of the endoscope tip during its inflation.
System for performing electromagnetic compatibility measurements, the system comprising: a signal source for generating a test signal; an amplifying unit with an input for receiving the generated test signal from the signal source, an amplifier for amplifying the received test signal and an output for outputting the amplified test signal; wherein the signal source is configured to limit a level of the generated test signal which is provided to the input of the amplifying unit to be below a predefined threshold value, wherein the predefined threshold level is set based on calibration data comprising one or more calibration values, wherein the signal source is configured to be removed from an arrangement comprising at least the signal source and the amplifier, and wherein the calibration values are determined based on measurements performed when the signal source is removed from the arrangement, the system further comprising a memory for storing the calibration data, wherein the memory is included in the signal source or the amplifying unit. a signal source for generating a test signal; an amplifying unit with an input for receiving the generated test signal from the signal source, an amplifier for amplifying the received test signal and an output for outputting the amplified test signal; wherein the signal source is configured to limit a level of the generated test signal which is provided to the input of the amplifying unit to be below a predefined threshold value, wherein the predefined threshold level is set based on calibration data comprising one or more calibration values, wherein the signal source is configured to be removed from an arrangement comprising at least the signal source and the amplifier, and wherein the calibration values are determined based on measurements performed when the signal source is removed from the arrangement, the system further comprising a memory for storing the calibration data, wherein the memory is included in the signal source or the amplifying unit.
An autoinjector comprising: - a syringe carrier and - a case adapted to receive the syringe carrier, the syringe carrier comprising: - a housing (16.0) adapted to receive a syringe having a needle encapsulated by a removable protective needle sheath, - two or more flexible arms (16.1) adapted to couple with the syringe in a mounted position, characterized in that the two or more flexible arms (16.1) protrude outwards in a relaxed state and wherein in the mounted position the flexible arms (16.1) are deflected radially inwards due, in part, to an axial force operating on the syringe carrier in order to force the syringe and the protective needle sheath apart. - a syringe carrier and - a case adapted to receive the syringe carrier, - a housing (16.0) adapted to receive a syringe having a needle encapsulated by a removable protective needle sheath, - two or more flexible arms (16.1) adapted to couple with the syringe in a mounted position, characterized in that the two or more flexible arms (16.1) protrude outwards in a relaxed state and wherein in the mounted position the flexible arms (16.1) are deflected radially inwards due, in part, to an axial force operating on the syringe carrier in order to force the syringe and the protective needle sheath apart.
A hand-held analytical device, in particular for blood sugar tests, comprising a replaceable test tape cassette which contains a test tape provided with a plurality of analytical aids, a tape drive comprising a DC motor and gearing (34, 36) which can be coupled to the test tape cassette for successive provision of the analytical aids and a control device for rotational speed control of the DC motor, characterized in that the control device comprises a rotary pickup arranged on the DC motor in order to record the ACTUAL rotational speed of the motor drive shaft.
A blood treatment machine, preferably of the dialysis machine type, comprising: a machine-internal hosing for the fluidic interconnection of a number of machine elements which are fixed to a machine housing and/or to racks supported in the machine housing; and at least one hose mount comprising a hose connection element as an inherent component of the machine-internal hosing, via which two hoses are fluidically firmly connected to each other and/or one hose is branched into two or more further hoses, wherein the hose connection element comprises at least two rigid sleeve portions integrally combined to form one rigid component and which are adapted to put a flexible hose radially outside over the free end of the at least two sleeve portions, wherein an axial stop is formed or arranged on the outer circumference of at least one of the sleeve portions at a distance from the free end thereof, characterized by a collar which is flexible as compared to the rigid sleeve portion and is arranged or formed on the sleeve portion toward the free end with an axial distance from the axial stop in order to define an external circumferential groove between itself and the axial stop, wherein the collar has a dowel shape such that the sleeve portion of the hose connection element equipped with the collar can be plugged from one side into a receiving hole of a housing wall or of a holding bracket mounted thereto, and the collar automatically and in resilient fashion spreads on the other side and in this way axially holds the housing wall or the holding bracket between itself and the axial stop.
A complex of a) a bi-specific antibody specific against digoxigenin and a target protein, comprising a first antigen-binding site that binds to digoxigenin and a second antigen-binding site that binds to a target protein, and b) digoxigenin, wherein the digoxigenin is conjugated to a therapeutic or diagnostic agent selected from the group consisting of a peptide, a small compound, a radioactively labeled small compound, and an imaging reagent, wherein said antigen-binding site specifically binding to digoxigenin comprises as heavy chain variable domain SEQ ID NO. 3 with the mutations S49A, I57A and A60P, and as light chain variable domain SEQ ID NO. 5. a) a bi-specific antibody specific against digoxigenin and a target protein, comprising a first antigen-binding site that binds to digoxigenin and a second antigen-binding site that binds to a target protein, and b) digoxigenin, wherein the digoxigenin is conjugated to a therapeutic or diagnostic agent selected from the group consisting of a peptide, a small compound, a radioactively labeled small compound, and an imaging reagent, wherein said antigen-binding site specifically binding to digoxigenin comprises as heavy chain variable domain SEQ ID NO. 3 with the mutations S49A, I57A and A60P, and as light chain variable domain SEQ ID NO. 5.
A compound of formula I or II wherein: X 1 is N or CH; Q is NH or O; A is chosen from direct bond, (C 1 -C 20)hydrocarbon, (C 1 -C 20)oxaalkyl and (C 1 -C 20)azaalkyl; R 1 is chosen from hydrogen, -C(=NH)NH 2, -C(=NH)NH(C 1 -C 10)hydrocarbon, fluoro(C 1 -C 6)hydrocarbon, and -CH(NH 2)COOH, with the provisos that, when A is a direct bond, R 1 cannot be H; when QR 3 is OH, R 1 cannot be fluoro(C 2 -C 6)hydrocarbon; R 2 is chosen from hydrogen, -C(=NH)NH 2, -C(=NH)NH(C 1 -C 10)hydrocarbon and -CH(NH 2)COOH; R 3 is chosen from H and (C 1 -C 20) hydrocarbon; and n is 1 or 2. X 1 is N or CH; Q is NH or O; A is chosen from direct bond, (C 1 -C 20)hydrocarbon, (C 1 -C 20)oxaalkyl and (C 1 -C 20)azaalkyl; R 1 is chosen from hydrogen, -C(=NH)NH 2, -C(=NH)NH(C 1 -C 10)hydrocarbon, fluoro(C 1 -C 6)hydrocarbon, and -CH(NH 2)COOH, with the provisos that, when A is a direct bond, R 1 cannot be H; when QR 3 is OH, R 1 cannot be fluoro(C 2 -C 6)hydrocarbon; when A is a direct bond, R 1 cannot be H; when QR 3 is OH, R 1 cannot be fluoro(C 2 -C 6)hydrocarbon; R 2 is chosen from hydrogen, -C(=NH)NH 2, -C(=NH)NH(C 1 -C 10)hydrocarbon and -CH(NH 2)COOH; R 3 is chosen from H and (C 1 -C 20) hydrocarbon; and n is 1 or 2.
A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, wherein the process comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), wherein before or in step (i) a particulate silicon oxide or metal oxide is dispersed or suspended in the reaction product mixture, the aqueous liquid or a combination thereof. (i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i),
Apparatus for a kite, comprising: a control arrangement comprising at least one aerodynamic control element (20, 21) in, or coupled to, the kite for aerodynamically controlling at least aspects of the flight of the kite; a tether connector for connecting the kite to a tether; and an energy extraction arrangement comprising a mechanical coupling to a wing of the kite and a generator, wherein the control arrangement is configured to control the wing so as to cause an alternating movement of the mechanical coupling to the wing with respect to the tether connector and the generator is configured to extract energy from said alternating movement, characterized in that the control arrangement is configured to control the kite to cause an alternating movement of the wing of the kite with respect to the tether connector so as to cause the alternating movement of the mechanical coupling. a control arrangement comprising at least one aerodynamic control element (20, 21) in, or coupled to, the kite for aerodynamically controlling at least aspects of the flight of the kite; a tether connector for connecting the kite to a tether; and an energy extraction arrangement comprising a mechanical coupling to a wing of the kite and a generator, wherein the control arrangement is configured to control the wing so as to cause an alternating movement of the mechanical coupling to the wing with respect to the tether connector and the generator is configured to extract energy from said alternating movement, characterized in that the control arrangement is configured to control the kite to cause an alternating movement of the wing of the kite with respect to the tether connector so as to cause the alternating movement of the mechanical coupling.
Valve, with a valve casing and a piston-like valve spool, which is mounted with axial sliding facility in a recess, with a central longitudinal axis, of the valve casing in order to execute linear changeover movements between different operating positions, and moreover with at least one seal ring coaxially encompassing the valve spool in the recess and having a multi-part annular seal housing with U-shaped cross-section, fixed immovably relative to the valve casing, and two opposing housing legs joined together by an annular base section lying radially outwards, arranged between the two housing legs, wherein at least one of the two housing legs is in the form of a body which is separate from the base section and is attached to the base section in a joining area, wherein the seal housing bounds a receiving space which has on the radial inside a slot-like housing opening flanked at the side by the two housing legs and in which is mounted coaxially an annular seal element, which is designed on the one hand for static sealing interaction with the inner face of the seal housing and on the other hand for dynamic sealing interaction with the outer peripheral face of the valve spool, wherein for the dynamic sealing the seal element has in the area of the slot-like housing opening a dynamic sealing section which encompasses the valve spool coaxially in at least one of its operating positions with sealing contact, characterised in that there is formed in the interior of the receiving space of the seal housing, in the radially inwards facing inner peripheral face of the base section, a sealing slot designed as an annular slot and open towards the radial inside, into which the seal element dips with its radially outwards aligned sealing section, which is designed for static sealing axial interaction with the two slot sides of the sealing slot lying opposite one another in the base section.
A pelt stretching machine for stretching a pelt on a pelt board, comprising a hair controller (10, 20, 26, 30, 50, 60), which stretching machine comprises at least one holder to engage the pelt, and wherein said hair controller (10, 20, 26, 30, 50, 60) comprises means for moving hair aside on the pelt to expose a selected area of leather on the pelt to allow the at least one holder to engage the selected area of leather.
A nucleic acid at least containing a single-stranded DNA to be delivered to endosomes of dendritic cells and a double-stranded RNA capable of activating TLR3, wherein the single-stranded DNA consists of a base sequence shown in any of SEQ ID NOS: 1 to 4 and 11 to 14, or of a partial sequence thereof, and wherein the double-stranded RNA capable of activating TLR3 has an RNA virus-derived RNA sequence.
A continuous casting method of steel supplying molten steel from a sliding nozzle provided at a bottom of a tundish through two discharge holes at the two sides of an immersion nozzle in the long axis direction toward the short side direction of a facing casting mold, said continuous casting method of steel characterized by using an immersion nozzle provided with an inside bore having a sectional area reduced from the top to the bottom and a horizontal sectional shape of an elliptical shape at the bottom of the inside bore and a circular shape at the top of the inside bore, the inside bore having the ratio S 1/ S 0 of 0.5 to 0.95, where S 1 is the sectional area of the smallest sectional area part of the inside bore and S 0 is the sectional area of the bore of the sliding nozzle, and a length ratio D L /D S of that long axis D L and short axis D S at right above the discharge holes of 1.2 to 3.8, arranging a direction of that long axis substantially parallel to a long side direction of the casting mold, arranging the sliding direction of the sliding nozzle in a direction perpendicular to said long axis to supply the molten steel in the casting mold, making a distance between an outer surface of the short axis side of the immersion nozzle and the inner wall of the long length side of the casting mold at least 50 mm and using an electromagnetic stirring apparatus to impart swirlability to the steel in the casting mold during casting.
A straight edge clamp comprising; an elongated body, a clamping head assembly and an end stop assembly; said elongated body has opposed edges, a top and a bottom, a main channel formed in said bottom, said clamping head assembly and said stop assembly are mounted within said main channel a spaced distance from one another; said stop assembly has a movable first jaw which is movable in the direction away from said clamping head assembly, from an unlocked position to a locked position; said clamping head assembly has a second jaw which is movable in the direction of said first jaw from a released position to a clamped position; whereby said bottom of said elongated body is adapted to be positioned against a work surface having sides and said clamping head assembly and stop assembly are adapted to be positioned against the sides, said second jaw is moved to said clamped position and said first jaw is moved to said locked position to clamp said straight edge clamp to said work surface; characterized in that said stop assembly includes at least one clamp pad mounted adjacent said first jaw, said first jaw being moveable with respect to said at least one clamp pad to move said clamp pad into engagement with said elongated body to said locked position; said main channel has sidewalls, said first jaw being moveable with respect to said at least one clamp pad to move said clamp pad into engagement with at least one of said sidewalls to said locked position; said first jaw includes a wedge member having at least one side extending at an acute angle with respect to the longitudinal center line of said elongated body, said side engaging said at least one clamp pad to engage said at least one sidewall.