A system comprising: one or more biometric sensors configured to capture biometric data of a pilot within a flight deck of an aircraft, wherein the biometric data is time variant and indicates a state of the pilot, wherein the biometric data includes at least one of video-based biometric data, audio-based biometric data, or wearables-based biometric data; wherein the one or more biometric sensors include a camera configured to capture a stream of images; wherein the biometric data includes the video-based biometric data; wherein the stream of images captures frames of images as an operator interacts with cockpit interfaces as the operator guides the aircraft through taxi, takeoff, and initial climb, scanning cockpit displays and windows throughout; a non-transitory memory maintaining program instructions; and one or more processors configured to execute the program instructions maintained on the memory, the program instructions causing the one or more processors to: receive the biometric data, aircraft state data, and mission profile data; wherein the mission profile data includes a phase of flight; wherein the phase of flight indicates the take-off state of the aircraft; perform data fusion on the biometric data, the aircraft state data, and the mission profile data to generate fused information with a common timestamp; apply an alerting algorithm to the fused information to determine an alert, the alert including at least one of an alert priority, an alert intensity, an alert frequency, or an alert modality which is based on the fused information; and provide the alert to an aircraft avionics system for alerting the pilot; characterized in that the alerting algorithm determines a co-pilot is not present in the cockpit and causes the aircraft avionics system to provide the alert to the pilot; wherein the alerting algorithm additionally determines whether to hand over control of the aircraft to an autonomous agent or autopilot depending on the context of one or more of the biometric data, the aircraft state data, or the mission profile data. one or more biometric sensors configured to capture biometric data of a pilot within a flight deck of an aircraft, wherein the biometric data is time variant and indicates a state of the pilot, wherein the biometric data includes at least one of video-based biometric data, audio-based biometric data, or wearables-based biometric data; wherein the one or more biometric sensors include a camera configured to capture a stream of images; wherein the biometric data includes the video-based biometric data; wherein the stream of images captures frames of images as an operator interacts with cockpit interfaces as the operator guides the aircraft through taxi, takeoff, and initial climb, scanning cockpit displays and windows throughout; a non-transitory memory maintaining program instructions; and one or more processors configured to execute the program instructions maintained on the memory, the program instructions causing the one or more processors to: receive the biometric data, aircraft state data, and mission profile data; wherein the mission profile data includes a phase of flight; wherein the phase of flight indicates the take-off state of the aircraft; perform data fusion on the biometric data, the aircraft state data, and the mission profile data to generate fused information with a common timestamp; apply an alerting algorithm to the fused information to determine an alert, the alert including at least one of an alert priority, an alert intensity, an alert frequency, or an alert modality which is based on the fused information; and provide the alert to an aircraft avionics system for alerting the pilot; characterized in that the alerting algorithm determines a co-pilot is not present in the cockpit and causes the aircraft avionics system to provide the alert to the pilot; wherein the alerting algorithm additionally determines whether to hand over control of the aircraft to an autonomous agent or autopilot depending on the context of one or more of the biometric data, the aircraft state data, or the mission profile data. receive the biometric data, aircraft state data, and mission profile data; wherein the mission profile data includes a phase of flight; wherein the phase of flight indicates the take-off state of the aircraft; perform data fusion on the biometric data, the aircraft state data, and the mission profile data to generate fused information with a common timestamp; apply an alerting algorithm to the fused information to determine an alert, the alert including at least one of an alert priority, an alert intensity, an alert frequency, or an alert modality which is based on the fused information; and provide the alert to an aircraft avionics system for alerting the pilot; characterized in that the alerting algorithm determines a co-pilot is not present in the cockpit and causes the aircraft avionics system to provide the alert to the pilot; wherein the alerting algorithm additionally determines whether to hand over control of the aircraft to an autonomous agent or autopilot depending on the context of one or more of the biometric data, the aircraft state data, or the mission profile data.