mhurhangee/ep-ind-claims huggingface dataset:
A polynucleic acid molecule that mediates RNA interference against MYC, comprising a sense strand and an antisense strand, wherein the sense strand comprises a sequence selected from SEQ ID NOs: 5 and 7 and the antisense strand comprises a sequence selected from SEQ ID NOs: 6 and 8, wherein the polynucleic acid molecule hybridizes to a MYC target sequence, and wherein: • the polynucleic acid molecule comprises at least one 2' modified nucleotide, at least five phosphorothioate internucleotide linkages, and at least one inverted abasic moiety; • the antisense strand comprises at least three consecutive phosphorothioate internucleotide linkage starting at the 5' terminus and at least one phosphorothioate internucleotide linkage at the 3' terminus; • the sense strand comprises at least one phosphorothioate internucleotide linkage; • the number of phosphorothioate internucleotide linkages in the sense strand is less than the number of phosphorothioate internucleotide linkages in the antisense strand; • the polynucleic acid molecule comprises from 90% to 100% modification; and • the sense strand and antisense strand are from 20 to 22 nucleotides in length. • the polynucleic acid molecule comprises at least one 2' modified nucleotide, at least five phosphorothioate internucleotide linkages, and at least one inverted abasic moiety; • the antisense strand comprises at least three consecutive phosphorothioate internucleotide linkage starting at the 5' terminus and at least one phosphorothioate internucleotide linkage at the 3' terminus; • the sense strand comprises at least one phosphorothioate internucleotide linkage; • the number of phosphorothioate internucleotide linkages in the sense strand is less than the number of phosphorothioate internucleotide linkages in the antisense strand; • the polynucleic acid molecule comprises from 90% to 100% modification; and • the sense strand and antisense strand are from 20 to 22 nucleotides in length.
Method for hydrophobing leather and furskins, characterised in that leather or furskins are treated before, during or after the retanning process with one or more formulations containing 1 to 30 wt. %, in relation to the formulation, of a mixture of polysiloxanes containing 10 to 90 wt. %, in relation to the mixture, of one or more carboxyl group-containing polysiloxanes, 90 to 10 wt. %, in relation to the mixture, of one or more carboxyl group-free polysiloxanes, and 3 to 25 wt. % in relation to the formulation of emulsifier, wherein the carboxyl group-containing polysiloxanes comprise polysiloxanes that contain the structural elements of formulas I, II and optionally IIIa and IIIb the variables of which are defined as follows: R 1 are equal or different and independently of one another are hydrogen, hydroxyl, C 1 -C 4 -alkyl, C 6 -C 14 -aryl, C 1 -C 4 -alkoxy, amino, mono-C 1 -C 4 -alkyl-amino, di-C 1 -C 4 -alkylamino or Z 1 -A 1 -COOH; A 1 are equal or different and are a linear or branched C 5 -C 25 -alkylene; Z 1 is a direct bond, oxygen or an amino, carbonyl, amido or ester group and wherein the carboxyl group-free polysiloxane(s) are linear or cyclic or branched and are formed of structural elements of formula I and optionally IIIa, IIIb and/or IVa where R 1 are equal or different and independently of one another are hydrogen, hydroxyl, C 1 -C 4 -alkyl, C 6 -C 14 -aryl, C 1 -C 4 -alkoxy, wherein - linear carboxyl group-free polysiloxanes comprise structural elements of formulas I, IIIa and/or IIIb, - cyclic carboxyl group-free polysiloxanes comprise structural elements of formula I, - branched carboxyl group-free polysiloxanes comprise structural elements of formulas I, IVa, IIIa and/or IIIb. R 1 are equal or different and independently of one another are hydrogen, hydroxyl, C 1 -C 4 -alkyl, C 6 -C 14 -aryl, C 1 -C 4 -alkoxy, amino, mono-C 1 -C 4 -alkyl-amino, di-C 1 -C 4 -alkylamino or Z 1 -A 1 -COOH; A 1 are equal or different and are a linear or branched C 5 -C 25 -alkylene; Z 1 is a direct bond, oxygen or an amino, carbonyl, amido or ester group and wherein - linear carboxyl group-free polysiloxanes comprise structural elements of formulas I, IIIa and/or IIIb, - cyclic carboxyl group-free polysiloxanes comprise structural elements of formula I, - branched carboxyl group-free polysiloxanes comprise structural elements of formulas I, IVa, IIIa and/or IIIb.
Distribution device for a specimen exposition arrangement that comprises at least two specimen receptacles and a fluid supply for fluid to be supplied to the specimen receptacles, the distribution device comprising: - a distribution means comprising -- a distribution means inlet for supplying fluid to the distribution device, -- for each specimen receptacle a respective distribution means outlet, and -- a distribution chamber between the distribution means inlet and the distribution means outlets; and - at least one fluid outlet means for each distribution means outlet, wherein the at least one fluid outlet means respectively comprises -- a fluid outlet means inlet being in fluid connection with the respective distribution means outlet, -- a first fluid outlet means outlet for outputting fluid in the respective specimen receptacle, and -- a second fluid outlet means outlet for outputting excess fluid; characterized in that the second fluid outlet means outlet is adapted to conduct away fluid supplied to fluid inlet means via the fluid outlet means inlet, which fluid shall not or cannot supplied to the respective specimen receptacle, and not the specimen receptacle. - a distribution means comprising -- a distribution means inlet for supplying fluid to the distribution device, -- for each specimen receptacle a respective distribution means outlet, and -- a distribution chamber between the distribution means inlet and the distribution means outlets; and -- a distribution means inlet for supplying fluid to the distribution device, -- for each specimen receptacle a respective distribution means outlet, and -- a distribution chamber between the distribution means inlet and the distribution means outlets; and - at least one fluid outlet means for each distribution means outlet, wherein the at least one fluid outlet means respectively comprises -- a fluid outlet means inlet being in fluid connection with the respective distribution means outlet, -- a first fluid outlet means outlet for outputting fluid in the respective specimen receptacle, and -- a second fluid outlet means outlet for outputting excess fluid; -- a fluid outlet means inlet being in fluid connection with the respective distribution means outlet, -- a first fluid outlet means outlet for outputting fluid in the respective specimen receptacle, and -- a second fluid outlet means outlet for outputting excess fluid;
Heat pump equipment for heating a heating circuit, with a condenser, an evaporator, an electronic expansion valve, a compressor unit with a first and second compressor (110, 120), which are switched in series, and a control unit for the control of the evaporator, of the condenser, of the electronic expansion valve and of the compressor unit (110, 120), where the control unit is designed in order to control the operation of the first and second compressor (110, 120), where the control unit has a compressor switch-on unit which is designed to output a signal that activates the first compressor, the second compressor, or the first and second compressor (110, 120), dependent on an outside temperature, a setpoint temperature of the heating circuit and/or a hot gas temperature recorded at the output of the compressor, identified in that the control unit has a rotation-speed limitation unit and a compressor-speed matching unit, where the rotation-speed limitation unit is equipped to limit the speed ranges of the first and/or second compressor (110, 120), and the compressor-speed matching unit is designed to ensure that a matching of the compressor speeds can be implemented in two-compressor operation.
Structural element forming a motor vehicle dashboard body that is intended to be installed in a transverse installation position inside a vehicle passenger compartment, having a one-piece openwork structure, which structure defines: - a first internal passage that passes all the way through the structural element and extends transversely when the structural element is in the installation position, the first passage being shaped so as to receive a crossmember that is in particular bent with a constant radius of curvature and having at least two fastening elements that are intended to be fastened to the crossmember, - a second internal passage that connects the first passage to a face of the structural element that is directed towards the rear of the vehicle when the structural element is in the installation position, the second passage having at least one fastening element (161, 162) that is intended to fasten a steering column fastening support, characterized in that the one-piece openwork structure is in the form of a network of material forming meshes and nodes, produced by three-dimensional printing, incorporating into the dashboard body enclosures for storage boxes, airbag housings, and aeraulic ducts. - a first internal passage that passes all the way through the structural element and extends transversely when the structural element is in the installation position, the first passage being shaped so as to receive a crossmember that is in particular bent with a constant radius of curvature and having at least two fastening elements that are intended to be fastened to the crossmember, - a second internal passage that connects the first passage to a face of the structural element that is directed towards the rear of the vehicle when the structural element is in the installation position, the second passage having at least one fastening element (161, 162) that is intended to fasten a steering column fastening support,
An apparatus for computing, comprising: a processor; and memory coupled with the processor, with instructions stored therein, wherein the instructions are configured to be operated by the processor to cause the apparatus: provide a management virtual machine, MVM, in a first secure enclave of the apparatus; provide a virtual machine trusted platform module, vTPM, for a guest virtual machine, VM, of the apparatus, the vTPM being provided in a second secure enclave of the apparatus different from the first secure enclave; receive, at the vTPM, a command to change a value stored in a platform configuration register, PCR, of the vTPM, wherein the command to change the value stored in the PCR is a command to extend the value stored in the PCR with a cryptographic hash of an integrity measurement of a VM resource associated with the PCR; receive, at the vTPM from the MVM through a secure channel, a modifier indicating that the command is allowed; and after receiving the modifier, change the value stored in the PCR. a processor; and memory coupled with the processor, with instructions stored therein, wherein the instructions are configured to be operated by the processor to cause the apparatus: provide a management virtual machine, MVM, in a first secure enclave of the apparatus; provide a virtual machine trusted platform module, vTPM, for a guest virtual machine, VM, of the apparatus, the vTPM being provided in a second secure enclave of the apparatus different from the first secure enclave; receive, at the vTPM, a command to change a value stored in a platform configuration register, PCR, of the vTPM, wherein the command to change the value stored in the PCR is a command to extend the value stored in the PCR with a cryptographic hash of an integrity measurement of a VM resource associated with the PCR; receive, at the vTPM from the MVM through a secure channel, a modifier indicating that the command is allowed; and after receiving the modifier, change the value stored in the PCR. provide a management virtual machine, MVM, in a first secure enclave of the apparatus; provide a virtual machine trusted platform module, vTPM, for a guest virtual machine, VM, of the apparatus, the vTPM being provided in a second secure enclave of the apparatus different from the first secure enclave; receive, at the vTPM, a command to change a value stored in a platform configuration register, PCR, of the vTPM, wherein the command to change the value stored in the PCR is a command to extend the value stored in the PCR with a cryptographic hash of an integrity measurement of a VM resource associated with the PCR; receive, at the vTPM from the MVM through a secure channel, a modifier indicating that the command is allowed; and after receiving the modifier, change the value stored in the PCR.
A fluid sensor comprising: a core defining a fluid flow path; and a cavity member located externally of the core and comprising an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix, wherein the cavity member is configured so as to provide confinement for an electromagnetic field and the core is configured so as to permit transmission therethrough of electromagnetic radiation at a frequency of the electromagnetic field, wherein the cavity member comprises a generally tubular main body portion and two end portions, each end portion located at a different end of the main body portion, and wherein the core extends through the main body portion and each of the end portions of the cavity member, wherein each of the end portions of the cavity member comprises a generally tubular member, wherein each of the end portions of the cavity member comprises a composite material including a matrix and one or more electrically-conductive reinforcing elements embedded within the matrix, and the one or more electrically-conductive reinforcing elements in each of the end portions of the cavity member are oriented helically at an angle of between 80 and 90 degrees with respect to a longitudinal axis of the cavity member. a core defining a fluid flow path; and a cavity member located externally of the core and comprising an electrically-conductive composite material including a matrix and one or more reinforcing elements embedded within the matrix,
A mounting system for a field device, comprising: at least one field device comprising a first housing part; at least one mounting adapter comprising a second housing part for captively receiving the first housing part; wherein one of the first and the second housing parts (230, 310) comprises first mounting means and second mounting means and the other of the first and the second housing parts (230, 310) comprises third mounting means; wherein the mounting means are arranged such that the field device is engageable with the second housing part in a first orientation and with the second housing part in a second orientation; wherein the third mounting means are engageable with the first mounting means in a first orientation of the field device and engageable with the second mounting means in a second orientation of the field device. at least one field device comprising a first housing part; at least one mounting adapter comprising a second housing part for captively receiving the first housing part; wherein one of the first and the second housing parts (230, 310) comprises first mounting means and second mounting means and the other of the first and the second housing parts (230, 310) comprises third mounting means; wherein the mounting means are arranged such that the field device is engageable with the second housing part in a first orientation and with the second housing part in a second orientation; wherein the third mounting means are engageable with the first mounting means in a first orientation of the field device and engageable with the second mounting means in a second orientation of the field device.
A method for determining an attenuation term for a signal produced by a magnetic transmitting element; comprising: driving the magnetic transmitting element with a first signal at a first frequency and a second signal at a second frequency to generate a first excitation signal and a second excitation signal, wherein the first frequency is lower than the second frequency; receiving a first received signal and a second received signal with a computer, the first received signal and the second received signal having been generated upon receipt of the first excitation signal and the second excitation signal with a magnetic position sensor; filtering the first received signal and the second received signal; and determining an attenuation term for the second received signal at the second frequency based on the first filtered and received signal and the second filtered and received signal, wherein the frequency of the first signal is in a range from 0.5 kilohertz to 2 kilohertz, and the frequency of the second signal is in a range from 10 kilohertz to 20 kilohertz. driving the magnetic transmitting element with a first signal at a first frequency and a second signal at a second frequency to generate a first excitation signal and a second excitation signal, wherein the first frequency is lower than the second frequency; receiving a first received signal and a second received signal with a computer, the first received signal and the second received signal having been generated upon receipt of the first excitation signal and the second excitation signal with a magnetic position sensor; filtering the first received signal and the second received signal; and determining an attenuation term for the second received signal at the second frequency based on the first filtered and received signal and the second filtered and received signal, wherein the frequency of the first signal is in a range from 0.5 kilohertz to 2 kilohertz, and the frequency of the second signal is in a range from 10 kilohertz to 20 kilohertz.
A window shade device for vehicles that is adapted to cover a first window and a second window provided adjacent to each other in a vehicle to be shielded and opened, comprising: a first window shade configured to shield said first window; a first windup device including a windup shaft member configured to wind up said first window shade and winding up said first window shade to be drawn/housed from/in said windup shaft member; a second window shade configured to shield said second window; a second windup device disposed in a position of intersecting an axis of the windup shaft member of said first windup device and winding up said second window shade to be drawn/housed therefrom/therein; a guide and support mechanism including a guide path member to be disposed along a drawing/housing direction of said second window shade and a movable member supported to be movable along the guide path member; a rack member connected with said movable member, disposed to be movable along said guide path member, and adapted to move said movable member along said guide path member by the movement along said guide path member; and an intermediate transmission mechanism including a first bevel gear connected to the windup shaft member of said first windup device to rotate in association therewith and a second bevel gear disposed to mesh with said first bevel gear and be associated with said rack member, and adapted to transmit the rotation of the windup shaft member of said first windup device as a force for moving said rack member along said guide path member. a first window shade configured to shield said first window; a first windup device including a windup shaft member configured to wind up said first window shade and winding up said first window shade to be drawn/housed from/in said windup shaft member; a second window shade configured to shield said second window; a second windup device disposed in a position of intersecting an axis of the windup shaft member of said first windup device and winding up said second window shade to be drawn/housed therefrom/therein; a guide and support mechanism including a guide path member to be disposed along a drawing/housing direction of said second window shade and a movable member supported to be movable along the guide path member; a rack member connected with said movable member, disposed to be movable along said guide path member, and adapted to move said movable member along said guide path member by the movement along said guide path member; and an intermediate transmission mechanism including a first bevel gear connected to the windup shaft member of said first windup device to rotate in association therewith and a second bevel gear disposed to mesh with said first bevel gear and be associated with said rack member, and adapted to transmit the rotation of the windup shaft member of said first windup device as a force for moving said rack member along said guide path member.
An endoscope system comprising: an objective optical system that is provided at an insertion portion tip and that is configured to acquire a subject image; an optical path division means configured to divide the subject image into two optical images with different focuses; an imaging element configured to form the two optical images with different focuses at the same time to acquire two images; an image correction means configured to correct the two images acquired by the imaging element so that differences other than the focuses become substantially the same; and an image combination processing unit configured to select an image with a higher contrast than the other image in each of predetermined corresponding areas between the two images corrected by the image correction means to generate a combined image, wherein the optical path division means is a polarization beam splitter, and a crystal filter including a crystal axis forming 45 degrees relative to an incident surface of the polarization beam splitter is arranged on an object side of the polarization beam splitter. an objective optical system that is provided at an insertion portion tip and that is configured to acquire a subject image; an optical path division means configured to divide the subject image into two optical images with different focuses; an imaging element configured to form the two optical images with different focuses at the same time to acquire two images; an image correction means configured to correct the two images acquired by the imaging element so that differences other than the focuses become substantially the same; and an image combination processing unit configured to select an image with a higher contrast than the other image in each of predetermined corresponding areas between the two images corrected by the image correction means to generate a combined image, wherein the optical path division means is a polarization beam splitter, and a crystal filter including a crystal axis forming 45 degrees relative to an incident surface of the polarization beam splitter is arranged on an object side of the polarization beam splitter.