A compound of the formula I: wherein: A is selected from: benzoimidazole, benzoisoxazole, benzoxazole, benzotriazole, cinnoline, dihydrobenzofuranone, furopyridinone, imidazopyridine, indazole, isobenzofuranone, isoindolinone, isoquinoline, oxazolopyridine, phenyl, pyrazolopyridine, pyrrolopyridinone, quinoline, and triazolopyridine; R 1 is selected from: hydrogen, halogen, -CN, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -C=CH, -pyrazolyl, -(C=O)-NH 2, and -(C=O)-NH(-C 1-6 alkyl); R 2 is selected from: hydrogen, halogen, -C 1-6 alkyl, and -NH 2; R 3 is selected from: hydrogen, halogen, -CN, -C 1-6 alkyl, and -NH 2; R 4 is selected from: hydrogen, -CN, chloro, and fluoro; R 5 is selected from: hydrogen, fluoro, and -CH 3; with the proviso that if A is isoindolinone or pyrrolopyridinone, then R 5 is fluoro; each of R 6 and R 7 is independently selected from: hydrogen, fluoro, and C 1-6 alkyl, or R 5, R 6 and R 7 are joined together to form a bicycle[2.2.1]heptane ring, with the proviso that if A is pyrazolopyridine, then at least one of R 6 and R 7 is other than hydrogen; each of R 8, R 9 and R 10 is independently selected from: hydrogen, halo, -OH, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -OC 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -C 3-6 cyclolkyl, which is unsubstituted or substituted with a hydroxy, methoxy, or 1-3 fluoro, -NH 2, -NH(C 1-6 alkyl), or -N(C 1-6 alkyl) 2, wherein the -C 1-6 alkyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, wherein the azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, and -CN; or a pharmaceutically acceptable salt thereof. A is selected from: benzoimidazole, benzoisoxazole, benzoxazole, benzotriazole, cinnoline, dihydrobenzofuranone, furopyridinone, imidazopyridine, indazole, isobenzofuranone, isoindolinone, isoquinoline, oxazolopyridine, phenyl, pyrazolopyridine, pyrrolopyridinone, quinoline, and triazolopyridine; R 1 is selected from: hydrogen, halogen, -CN, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -C=CH, -pyrazolyl, -(C=O)-NH 2, and -(C=O)-NH(-C 1-6 alkyl); hydrogen, halogen, -CN, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -O-C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, -C=CH, -pyrazolyl, -(C=O)-NH 2, and -(C=O)-NH(-C 1-6 alkyl); R 2 is selected from: hydrogen, halogen, -C 1-6 alkyl, and -NH 2; hydrogen, halogen, -C 1-6 alkyl, and -NH 2; R 3 is selected from: hydrogen, halogen, -CN, -C 1-6 alkyl, and -NH 2; hydrogen, halogen, -CN, -C 1-6 alkyl, and -NH 2; R 4 is selected from: hydrogen, -CN, chloro, and fluoro; hydrogen, -CN, chloro, and fluoro; R 5 is selected from: hydrogen, fluoro, and -CH 3; hydrogen, fluoro, and -CH 3; with the proviso that if A is isoindolinone or pyrrolopyridinone, then R 5 is fluoro; each of R 6 and R 7 is independently selected from: hydrogen, fluoro, and C 1-6 alkyl, or R 5, R 6 and R 7 are joined together to form a bicycle[2.2.1]heptane ring, with the proviso that if A is pyrazolopyridine, then at least one of R 6 and R 7 is other than hydrogen; hydrogen, fluoro, and C 1-6 alkyl, or R 5, R 6 and R 7 are joined together to form a bicycle[2.2.1]heptane ring, with the proviso that if A is pyrazolopyridine, then at least one of R 6 and R 7 is other than hydrogen; each of R 8, R 9 and R 10 is independently selected from: hydrogen, halo, -OH, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -OC 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -C 3-6 cyclolkyl, which is unsubstituted or substituted with a hydroxy, methoxy, or 1-3 fluoro, -NH 2, -NH(C 1-6 alkyl), or -N(C 1-6 alkyl) 2, wherein the -C 1-6 alkyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, wherein the azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, and -CN; hydrogen, halo, -OH, -C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -OC 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, -OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro, -C 3-6 cyclolkyl, which is unsubstituted or substituted with a hydroxy, methoxy, or 1-3 fluoro, -NH 2, -NH(C 1-6 alkyl), or -N(C 1-6 alkyl) 2, wherein the -C 1-6 alkyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, wherein the azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, and -CN; or a pharmaceutically acceptable salt thereof.