A compound selected from the group consisting of: 4-(8-amino-3-((6S,8aR)-6-methyl-3-oxohexahydro-1H-oxazolo[3,4-a]pyridin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide; 4-(8-amino-3-((6S,8aR)-6-methyl-3-oxohexahydro-1H-oxazolo[3,4-a]pyridin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)benzamide; 4-{8-amino-3-[(7S,9aR)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7S,9aR)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl} -N-(4-cyclopropylpyridin-2-yl)-3 -fluorobenzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-5-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-2-chloro-5-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-(8-amino-3-((6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide and 4-(8-amino-3-((6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide; or a pharmaceutically acceptable salt thereof 4-(8-amino-3-((6S,8aR)-6-methyl-3-oxohexahydro-1H-oxazolo[3,4-a]pyridin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide; 4-(8-amino-3-((6S,8aR)-6-methyl-3-oxohexahydro-1H-oxazolo[3,4-a]pyridin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)benzamide; 4-{8-amino-3-[(7S,9aR)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7S,9aR)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl} -N-(4-cyclopropylpyridin-2-yl)-3 -fluorobenzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-5-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-3-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(7R,9aS)-7-methyl-2-(1-methylethyl)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazin-7-yl]imidazo[1,5-a]pyrazin-1-yl}-2-chloro-5-ethoxy-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzamide; 4-{8-amino-3-[(6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 4-(8-amino-3-((6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-ethoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide and 4-(8-amino-3-((6R,8aS)-6-methyl-3-oxooctahydroindolizin-6-yl)imidazo[1,5-a]pyrazin-1-yl)-3-methoxy-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;