mhurhangee/ep-ind-claims huggingface dataset:
Compounds of formula: wherein ring A is a 5- or 6-membered aromatic or heteroaromatic ring, and therefore a group chosen from P, Q, R or T may be absent; P, Q, R and T independently of one another are chosen from CH, N, O and S; R1 and R2 independently of one another are chosen from hydrogen, halogen, Ak, O-Ak, Ph, O-Ph, Ph-Ak, heteroaryl, CF 3, OCF 3, NO 2, NH 2, NH-Ak, NAk 2, COOAk, S-Ak, S02-Ak, CN; R3 is chosen from hydrogen, halogen, Ak, OAk, O-CO-Ak, OH; Y is chosen from O and S; W is O, if present; V is chosen from CH or C if substituted by R1, and N; X is chosen from CH2, O, NH, NAk and n = 1,2,3; wherein Ak means alkyl; in the compounds of formula, optical isomers, enantiomers or diastereoisomers and mixtures thereof, and pharmaceutically acceptable organic and inorganic salts are intended to be included. ring A is a 5- or 6-membered aromatic or heteroaromatic ring, and therefore a group chosen from P, Q, R or T may be absent; P, Q, R and T independently of one another are chosen from CH, N, O and S; R1 and R2 independently of one another are chosen from hydrogen, halogen, Ak, O-Ak, Ph, O-Ph, Ph-Ak, heteroaryl, CF 3, OCF 3, NO 2, NH 2, NH-Ak, NAk 2, COOAk, S-Ak, S02-Ak, CN; R3 is chosen from hydrogen, halogen, Ak, OAk, O-CO-Ak, OH; Y is chosen from O and S; W is O, if present; V is chosen from CH or C if substituted by R1, and N; X is chosen from CH2, O, NH, NAk and n = 1,2,3; wherein Ak means alkyl; in the compounds of formula, optical isomers, enantiomers or diastereoisomers and mixtures thereof, and pharmaceutically acceptable organic and inorganic salts are intended to be included.
An automated process for generation of genetically modified T cells, T cell subsets and/or T cell progenitors comprising the steps: a) providing a cell sample comprising T cells, T cell subsets and/or T cell progenitors b) preparation of the cell sample by centrifugation c) magnetic separation of the T cells, T cell subsets and/or T cell progenitors d) activation of the enriched T cells, T cell subsets and/or T cell progenitors using modulatory agents e) genetic modification of the T cells, T cell subsets and/or T cell progenitors f) expansion of the genetically modified T cells, T cell subsets and/or T cell progenitors in a cultivation chamber g) washing of the cultured T cells, T cell subsets and/or T cell progenitors characterized in that all steps are performed in a closed and sterile cell culture system. a) providing a cell sample comprising T cells, T cell subsets and/or T cell progenitors b) preparation of the cell sample by centrifugation c) magnetic separation of the T cells, T cell subsets and/or T cell progenitors d) activation of the enriched T cells, T cell subsets and/or T cell progenitors using modulatory agents e) genetic modification of the T cells, T cell subsets and/or T cell progenitors f) expansion of the genetically modified T cells, T cell subsets and/or T cell progenitors in a cultivation chamber g) washing of the cultured T cells, T cell subsets and/or T cell progenitors characterized in that all steps are performed in a closed and sterile cell culture system.
A method for reseeding harvested adherent cells grown in growth media in a hollow fiber bioreactor having an intracapillary space and an extracapillary space, wherein a cell growth space is one of the intracapillary space or the extracapillary space, said method comprising the steps of: removing the growth media from the cell growth space; washing the cells to remove residual growth media from the cell growth space; loosening the cells from the cell growth space by adding trypsin to the cell growth space; removing the cells and any trypsin from the cell growth space using complete media to push the cells out of the cell growth space through a cell harvest path; adding a harvest media to the cells, wherein said harvest media comprises protein and metabolites; wherein said protein inactivates the trypsin from the removed cells; wherein said metabolites are to compensate for a lack of ions in the cellular environment; and said method further comprising: without an additional washing step, reseeding the cells into the cell growth space of the or a hollow fiber bioreactor. removing the growth media from the cell growth space; washing the cells to remove residual growth media from the cell growth space; loosening the cells from the cell growth space by adding trypsin to the cell growth space; removing the cells and any trypsin from the cell growth space using complete media to push the cells out of the cell growth space through a cell harvest path; adding a harvest media to the cells, wherein said harvest media comprises protein and metabolites; wherein said protein inactivates the trypsin from the removed cells; wherein said metabolites are to compensate for a lack of ions in the cellular environment; and said method further comprising: without an additional washing step, reseeding the cells into the cell growth space of the or a hollow fiber bioreactor.
A method of predicting the efficacy of using iloperidone or a pharmaceutically-acceptable salt of iloperidone in the treatment of at least one psychotic symptom in an individual, the method comprising: determining the individual's genotype at the single nucleotide polymorphism locus rs7837682; and in the case that the individual's genotype at the SNP locus rs7837682 is AA, predicting that treating the individual with iloperidone will be efficacious. determining the individual's genotype at the single nucleotide polymorphism locus rs7837682; and in the case that the individual's genotype at the SNP locus rs7837682 is AA, predicting that treating the individual with iloperidone will be efficacious.
A computer-implemented method in a computing environment for graphically associating two objects in a drawing application with one another, the method comprising: receiving a command to designate a target, the target including a first object (320, 1220) on a drawing area (305, 1205) of the drawing application; designating the target; receiving a command to designate a subject, the subject including a second object (320, 1230) selected in a list of objects in an area of the drawing application separate from the drawing area; displaying at least two suggested associations between the first object and the second object in the drawing area, wherein each suggested association is a visual indication identifying a direction relative to the target first object; receiving a command to select a given suggested association of the at least two suggested associations between the first object and the second object; and associating the second object with the first object on the drawing area according to the selected given suggested association. receiving a command to designate a target, the target including a first object (320, 1220) on a drawing area (305, 1205) of the drawing application; designating the target; receiving a command to designate a subject, the subject including a second object (320, 1230) selected in a list of objects in an area of the drawing application separate from the drawing area; displaying at least two suggested associations between the first object and the second object in the drawing area, wherein each suggested association is a visual indication identifying a direction relative to the target first object; receiving a command to select a given suggested association of the at least two suggested associations between the first object and the second object; and associating the second object with the first object on the drawing area according to the selected given suggested association.
Bicycle or e-bike interface for providing a connection between a bicycle or e-bike and a data processing device, e.g. a mobile device, wherein the bicycle or e-bike interface has a plug, a plug socket, a holder and attachment means, wherein the plug socket is displaceably attached to the holder by means of the attachment means, wherein the holder is designed to be fixed to the bicycle or e-bike, characterized in that the attachment means are designed in such a way that they enable a displacement of the plug socket relative to the holder between a first, preferably pivoted-in, position of the plug socket, in which the plug is at least partially recessed in the holder and a second, preferably pivoted-out position, of the plug socket, in which the plug is arranged at least partially outside the holder.
A flux regulated permanent magnet brushless motor comprising: a stator having an inner peripheral bore; a permanent magnet rotor mounted within said inner peripheral bore; a control coil to regulate flux of the machine; and wherein the motor is configured to supply a DC current to the control coil, and characterised in that the motor is configured to also supply a small AC current to the control coil and the motor further comprises a detector (114, 119) configured to detect a responsive signal to determine a position of the permanent magnet rotor. a stator having an inner peripheral bore; a permanent magnet rotor mounted within said inner peripheral bore; a control coil to regulate flux of the machine; and wherein the motor is configured to supply a DC current to the control coil, and characterised in that the motor is configured to also supply a small AC current to the control coil and the motor further comprises a detector (114, 119) configured to detect a responsive signal to determine a position of the permanent magnet rotor.
Method for observing the presence, location, movement and/or attitude of one or more objects (106, 601) to be monitored with a monitoring system, the system comprises at least one sensor, measuring electronics and a processor configured to process the sensor data, wherein the at least one sensor of the system is disposed on a floor, wall and/or ceiling of the area to be monitored and the system measures with a sensor or with sensors the area to be monitored, and determines the presence, location, movement and/or attitude of the object (106, 601) on the basis of the measurement results of the sensor or sensors, characterized in that the system has a first mode and a second mode, and the system checks in the first mode the attitude and/or state of health of the object in the area to be monitored and the system functions in the second mode as an intruder alarm monitoring the area to be monitored, and wherein the system uses the same sensor in both the first mode for checking the attitude and/or state of health of the object in the area to be monitored and also in the second mode as an intruder alarm for monitoring the area to be monitored, and wherein the sensor comprises two motion detectors (302, 303) and is adapted to measure two sectors that are at different heights, corresponding to a top part and a bottom part of the area to be monitored, wherein the system operating in a first mode monitors the following alarm conditions: item 1. if movement is detected in the top part of the area to be monitored go to item 2., item 2. if movement is detected only in the bottom part of the area to be monitored go to tem 3., item 3. wait for a predetermined time period, if movement is detected in the top part of the area to be monitored go to item 1, else item 4. give a fall alarm and go to item 1, and wherein operating in the second mode the system performs intruder alarm procedures when it detects with the sensor an object in the area to be monitored, wherein the motion detectors (302, 303) of the sensors are passive infrared sensors, ultrasound sensors, microwave sensors or combination sensors, such as a combination of a passive infrared sensor and a microwave sensor or a combination of two passive infrared sensors. item 1. if movement is detected in the top part of the area to be monitored go to item 2., item 2. if movement is detected only in the bottom part of the area to be monitored go to tem 3., item 3. wait for a predetermined time period, if movement is detected in the top part of the area to be monitored go to item 1, else item 4. give a fall alarm and go to item 1, and
Circuit arrangement comprising at least one circuit carrier having at least one conductor structure formed on the circuit carrier, wherein the conductor structure has at least one first and one second electrical contact point (24, 25), and at least one electrical and/or electronic component having at least one first and one second connection region (51, 52), wherein, to form a circuit, the at least first contact point of the conductor structure is directly or indirectly electrically connected to the at least first electrical connection region of the electrical and/or electronic component and/or wherein the at least second contact point of the conductor structure is directly or indirectly electrically connected to the at least second connection region of the electrical and/or electronic component, characterized in that the at least one electrical and/or electronic component is arranged to reduce transmission of mechanical loads from the at least one circuit carrier to at least one carrier element and is indirectly connected to the at least one circuit carrier by means of the at least one carrier element by virtue of the at least one carrier element being connected to the at least one circuit carrier, wherein the carrier element has a greater tensile, compressive and/or flexural strength than the at least one electrical and/or electronic component.
An anti-vandalism fabric suitable for upholstering seats comprising at least one thread (1; 1a, 1b) intertwined with itself forming a mesh (3; 3a, 3b), characterized in that said thread (1; 1a, 1b) is in turn formed by a bundle of between 3 and 14 filaments or of a combination of between 3 and 14 filaments and spun yarns, wherein said filaments or the filaments and spun yarns are not plaited with one another, the bundle comprising at least 3 metal filaments, the metal filaments of the bundle having a diameter between 0.05 mm and 0.09 mm.
A method of decoding video data, the method comprising: receiving, in a picture parameter set, PPS, a first syntax element indicating that a palette predictor is to be generated using PPS-level palette predictor initializers; in response to the first syntax element indicating that the palette predictor is to be generated using the PPS-level palette predictor initializers, receiving, in the PPS, a second syntax element indicating a number of the PPS-level palette predictor initializers included in the PPS is equal to zero; in response to the second syntax element indicating the number of PPS-level palette predictor initializers included in the PPS is equal to zero, receiving one or more palette table entry values; generating a palette table that includes the one or more palette table entry values; and decoding a block of video data based on the palette table. receiving, in a picture parameter set, PPS, a first syntax element indicating that a palette predictor is to be generated using PPS-level palette predictor initializers; in response to the first syntax element indicating that the palette predictor is to be generated using the PPS-level palette predictor initializers, receiving, in the PPS, a second syntax element indicating a number of the PPS-level palette predictor initializers included in the PPS is equal to zero; in response to the second syntax element indicating the number of PPS-level palette predictor initializers included in the PPS is equal to zero, receiving one or more palette table entry values; generating a palette table that includes the one or more palette table entry values; and decoding a block of video data based on the palette table.
A venipuncture assist device (100, 200, 300), comprising: a main body (101, 102; 302a, 302b) having a bottom surface portion for confronting a target venipuncture tissue site; a vein capture channel configured to receive a vein portion of said target venipuncture tissue site therein by a vacuum urging force; a vacuum port (130, 132, 310) disposed on said main body (101, 102; 302a, 302b) configured to provide a reduced atmospheric pressure within said vein capture channel; and a first needle channel (150, 151, 152, 153) configured to receive a venipuncture needle (185, 385) and arranged so that said venipuncture needle (185, 385) can be advanced into said vein portion at a first incidence angle, characterized in that i) said vein capture channel is disposed within said bottom surface portion and ii) said first needle channel (150, 151, 152, 153) extends from a front face of said main body (101, 102; 302a, 302b) to said vein capture channel. a main body (101, 102; 302a, 302b) having a bottom surface portion for confronting a target venipuncture tissue site; a vein capture channel configured to receive a vein portion of said target venipuncture tissue site therein by a vacuum urging force; a vacuum port (130, 132, 310) disposed on said main body (101, 102; 302a, 302b) configured to provide a reduced atmospheric pressure within said vein capture channel; and a first needle channel (150, 151, 152, 153) configured to receive a venipuncture needle (185, 385) and arranged so that said venipuncture needle (185, 385) can be advanced into said vein portion at a first incidence angle, i) said vein capture channel is disposed within said bottom surface portion and ii) said first needle channel (150, 151, 152, 153) extends from a front face of said main body (101, 102; 302a, 302b) to said vein capture channel.
Balancing weight for a rotor blade of a turbine stage of a gas turbine, in particular an aircraft gas turbine, comprising a first curved fastening section that can be coupled to an axial leading edge of a shroud of the rotor blade, a second fastening section that can be coupled to an axial trailing edge of the shroud, and a middle section connecting the first fastening section and the second fastening section, the balancing weight being designed as a strip-like metal element that has a plurality of curved regions starting from a first end as far as a second end, characterized in that, prior to the balancing weight being assembled on the rotor blade, the middle section has a torsion section, in which the strip-like metal element is twisted, in particular by approximately 90°, about the longitudinal axis of the strip, which corresponds to an axial direction of the gas turbine, in a first rotational direction, the second fastening section extending downward, with respect to the longitudinal axis of the strip, which corresponds to a radial direction of the gas turbine; and that, when assembled on the rotor blade, the middle section is twisted in a second rotational direction, which is counter to the first rotational direction, such that the torsion section is stretched, the middle section being guided along the shroud in a torsion-free manner.
A device for supporting at least one arm of a user, wherein the device has - at least one arm support element with an arm shell for placing on the arm, - at least one passive actuator, ∘ which is configured to apply a force to the at least one support element that is directed against the force of gravity, and - at least one counter bearing for the force to be applied, which comprises ∘ at least one counter bearing element and ∘ at least one force transmission element that is configured to transmit a counter force to the counter bearing element, ∘ wherein the arm support element is connected to the force transmission element via a joint, characterized by the fact that the device is configured in such a way that a freedom of movement of the spine of the user is not restricted by the device, wherein particularly an inclination is possible and wherein the joint is configured and designed to allow for an abduction and/or adduction of the arm of the user when the device is in the mounted state. - at least one arm support element with an arm shell for placing on the arm, - at least one passive actuator, ∘ which is configured to apply a force to the at least one support element that is directed against the force of gravity, and ∘ which is configured to apply a force to the at least one support element that is directed against the force of gravity, and - at least one counter bearing for the force to be applied, which comprises ∘ at least one counter bearing element and ∘ at least one force transmission element that is configured to transmit a counter force to the counter bearing element, ∘ wherein the arm support element is connected to the force transmission element via a joint, characterized by the fact that the device is configured in such a way that a freedom of movement of the spine of the user is not restricted by the device, wherein particularly an inclination is possible and wherein the joint is configured and designed to allow for an abduction and/or adduction of the arm of the user when the device is in the mounted state. ∘ at least one counter bearing element and ∘ at least one force transmission element that is configured to transmit a counter force to the counter bearing element, ∘ wherein the arm support element is connected to the force transmission element via a joint,
A sensor housing having at least one sensor element, wherein the sensor housing has a rail-like housing projection that is provided for reception in a groove extending along a linear drive housing, wherein at least one elongated rail-like conductor board is arranged in this housing projection in its longitudinal direction, wherein the housing projection has planar side surfaces so that no undercut is formed, and wherein the spacing of the side surfaces is smaller than the spacing of a groove opening of the groove, characterized in that the sensor housing has at least one electrically conductive thread and an electrically conductive fastening screw received therein for fixing the sensor housing in the groove, with the thread being connected to an electric potential, in particular to a ground potential, of the sensor, with a conductive ground screw being arranged in the sensor housing that contacts the fastening screw, and with the ground screw being connected to an electric potential, in particular to a ground potential, of the sensor.
A cylinder liner, comprising: a substrate including an inner surface extending around a center axis; a coating disposed on said inner surface of said substrate; said coating including an intermediate layer, said intermediate layer comprising, in weight percent (wt. %) of said intermediate layer, 40.0 to 60.0 wt. % carbon, 15.0 to 35.0 wt. % silicon, and 15.0 to 35.0 wt. % germanium; and said coating including a protective layer, said protective layer including, in weight percent (wt. %) of said protective layer, at least 90.0 wt. % carbon, wherein the weight of said layers (38, 40) does not include the weight of any hydrogen present in said layers (38, 40), wherein each of said layers (38, 40) of said coating has a thickness (t i, t p) of not greater than 30 microns, wherein at least one of said layers (38, 40) has a composition varying along said thickness (t i, t p). a substrate including an inner surface extending around a center axis; a coating disposed on said inner surface of said substrate; said coating including an intermediate layer, said intermediate layer comprising, in weight percent (wt. %) of said intermediate layer, 40.0 to 60.0 wt. % carbon, 15.0 to 35.0 wt. % silicon, and 15.0 to 35.0 wt. % germanium; and said coating including a protective layer, said protective layer including, in weight percent (wt. %) of said protective layer, at least 90.0 wt. % carbon, wherein the weight of said layers (38, 40) does not include the weight of any hydrogen present in said layers (38, 40), wherein each of said layers (38, 40) of said coating has a thickness (t i, t p) of not greater than 30 microns, wherein at least one of said layers (38, 40) has a composition varying along said thickness (t i, t p).