An ophthalmic solution consisting of: hydroxypropyl methylcellulose having 28.0 to 30.0 mass% methoxy groups and 7.0 to 12.0 mass% hydroxypropoxy groups, both with respect to a total amount of said hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass% aqueous solution of said hydroxypropyl methylcellulose at 20 °C has a viscosity of 50 to 4000 mPa·s; sodium chloride and/or potassium chloride; hexamethylene biguanide represented by formula or a salt thereof: wherein k denotes the number of repeating units and is an integer of 3 to 40; 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer represented by formula: wherein m and n each denotes a molar ratio of respective constitutional unit, and m/n is 70/30 to 90/10 by mole; water; and one or more components selected from the group consisting of: surfactants, polyhydric alcohols, algefacients, chelating agents, inorganic salts, salts of organic acid, acids, bases, tonicity agents, antioxidants, or preservatives other than biguanides, wherein the surfactants are selected from the group consisting of: higher fatty acids or salts thereof, alkylsulfuric acids or salts thereof, alkylsulfonic acids or salts thereof, polyoxyethylene alkylsulfuric acids or salts thereof, polyoxyethylene alkyl ethers, sugar esters, sugar ethers, imidazoline, or betaine, wherein the polyhydric alcohols are selected from the group consisting of: propylene glycol, glycerin, glucose, mannitol, sorbitol, xylitol, or trehalose, wherein the algefacients are selected from the group consisting of: menthol or camphor, wherein the chelating agents are selected from the group consisting of: ethylenediaminetetraacetic acid, citric acid, or etidronic acid, wherein the inorganic salt is selected from the group consisting of borax, sodium hydrogen carbonate, sodium hydrogen phosphate, or sodium dihydrogen phosphate anhydrous, wherein the salts of organic acid are selected from the group consisting of sodium citrate, wherein the acids are selected from the group consisting of: boric, phosphoric, sulfuric, acetic, or hydrochloric acid, wherein the bases are selected from the group consisting of: sodium hydroxide, potassium hydroxide, Trometamol, or monoethanolamine, and wherein a content of is 0.1 to 0.2 %w/v, a content of is 0.01 to 1.5 %w/v, a content of is 0.00005 to 0.00015 %w/v, and a content of is 0.05 to 0.15 %w/v, all with respect to a total amount of said ophthalmic solution. hydroxypropyl methylcellulose having 28.0 to 30.0 mass% methoxy groups and 7.0 to 12.0 mass% hydroxypropoxy groups, both with respect to a total amount of said hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass% aqueous solution of said hydroxypropyl methylcellulose at 20 °C has a viscosity of 50 to 4000 mPa·s; sodium chloride and/or potassium chloride; hexamethylene biguanide represented by formula or a salt thereof: wherein k denotes the number of repeating units and is an integer of 3 to 40; 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer represented by formula: wherein m and n each denotes a molar ratio of respective constitutional unit, and m/n is 70/30 to 90/10 by mole; water; and one or more components selected from the group consisting of: surfactants, polyhydric alcohols, algefacients, chelating agents, inorganic salts, salts of organic acid, acids, bases, tonicity agents, antioxidants, or preservatives other than biguanides, wherein the surfactants are selected from the group consisting of: higher fatty acids or salts thereof, alkylsulfuric acids or salts thereof, alkylsulfonic acids or salts thereof, polyoxyethylene alkylsulfuric acids or salts thereof, polyoxyethylene alkyl ethers, sugar esters, sugar ethers, imidazoline, or betaine, wherein the polyhydric alcohols are selected from the group consisting of: propylene glycol, glycerin, glucose, mannitol, sorbitol, xylitol, or trehalose, wherein the algefacients are selected from the group consisting of: menthol or camphor, wherein the chelating agents are selected from the group consisting of: ethylenediaminetetraacetic acid, citric acid, or etidronic acid, wherein the inorganic salt is selected from the group consisting of borax, sodium hydrogen carbonate, sodium hydrogen phosphate, or sodium dihydrogen phosphate anhydrous, wherein the salts of organic acid are selected from the group consisting of sodium citrate, wherein the acids are selected from the group consisting of: boric, phosphoric, sulfuric, acetic, or hydrochloric acid, wherein the bases are selected from the group consisting of: sodium hydroxide, potassium hydroxide, Trometamol, or monoethanolamine, and wherein a content of is 0.1 to 0.2 %w/v, a content of is 0.01 to 1.5 %w/v, a content of is 0.00005 to 0.00015 %w/v, and a content of is 0.05 to 0.15 %w/v, all with respect to a total amount of said ophthalmic solution.