A compound of Formula: or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: R 1 is independently selected from the group consisting of: phenyl and a 5- to 6-membered heteroaryl comprising: carbon atoms and 1-4 heteroatoms selected from N, NR c, O, and S p; wherein each phenyl and heteroaryl are substituted with 0-3 R a; R 2 is, independently at each occurrence, selected from the group consisting of: halogen, OH, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, CN, NH 2, NO 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), and CONH 2; R 3 is independently selected from the group consisting of: C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, -(CH 2) m CHF 2, -(CH 2) m CF 3, -(CH 2) m -(C 3-6 carbocycle substituted with 0-3 R b), -(CH 2) m -(pyridyl substituted with 0-2 R b), -NH(C 1-4 alkyl), -NHCH 2 CO 2 (C 1-4 alkyl), -NH(4-halo-Ph), 4-CF 3 -Ph, -NHBn, and R 4 independently selected from the group consisting of: R 5 is independently selected from the group consisting of: NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CONH 2, CONH(C 1-4 alkyl), CON(C 1-4 alkyl) 2, NHCO(C 1-4 alkyl), NHCO 2 (C 1-4 alkyl), NHCONH(C 1-4 alkyl), SO 2 OH, SO 2 (4-halo-Ph), SO 2 NH 2, SO 2 NHCH 2 CF 3, SO 2 NHPh, NHSO 2 NH 2, NHSO 2 (C 1-4 alkyl), SO 2 NHSO 2 (CH 2) 2-3 CF 3, N(C 1-4 alkyl)SO 2 NH 2, N(CO 2 C 1-4 alkyl)SO 2 (C 1-4 alkyl), and R 6 is independently selected from the group consisting of: R a is, independently at each occurrence, selected from the group consisting of: halogen, C 1-6 alkyl substituted with 0-1 OH, C 1-4 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, OH, CN, NO 2, NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), CONH 2, CONH(C 1-4 alkyl), SO 2 NH 2, SO 2 N(C 1-4 alkyl) 2, CONH(CH 2) 1-3 CF 3, pyrazolyl, and R b is, independently at each occurrence, selected from the group consisting of: halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, OH, CN, NH 2, NO 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), SO 2 (C 1-4 alkyl), SO 2 NH 2, CONH 2, and CONH(C 1-4 alkyl); R c is, independently at each occurrence, selected from the group consisting of: H, C 1-6 alkyl, CO(C 1-4 alkyl), CO 2 (C 1-4 alkyl), COBn, CO 2 Bn, pyrimidinyl and -(CH 2) t -(C 3-6 carbocycle substituted with 0-2 R e); R e is, independently at each occurrence, selected from the group consisting of: halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, and C 1-4 haloalkoxy; m and t are, independently at each occurrence, selected from 0, 1, 2, and 3; and p is, independently at each occurrence, selected from 0, 1, and 2; and s is, independently at each occurrence, selected from 1, 2, and 3. R 1 is independently selected from the group consisting of: phenyl and a 5- to 6-membered heteroaryl comprising: carbon atoms and 1-4 heteroatoms selected from N, NR c, O, and S p; wherein each phenyl and heteroaryl are substituted with 0-3 R a; R 2 is, independently at each occurrence, selected from the group consisting of: halogen, OH, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, CN, NH 2, NO 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), and CONH 2; R 3 is independently selected from the group consisting of: C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, -(CH 2) m CHF 2, -(CH 2) m CF 3, -(CH 2) m -(C 3-6 carbocycle substituted with 0-3 R b), -(CH 2) m -(pyridyl substituted with 0-2 R b), -NH(C 1-4 alkyl), -NHCH 2 CO 2 (C 1-4 alkyl), -NH(4-halo-Ph), 4-CF 3 -Ph, -NHBn, and R 4 independently selected from the group consisting of: R 5 is independently selected from the group consisting of: NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CONH 2, CONH(C 1-4 alkyl), CON(C 1-4 alkyl) 2, NHCO(C 1-4 alkyl), NHCO 2 (C 1-4 alkyl), NHCONH(C 1-4 alkyl), SO 2 OH, SO 2 (4-halo-Ph), SO 2 NH 2, SO 2 NHCH 2 CF 3, SO 2 NHPh, NHSO 2 NH 2, NHSO 2 (C 1-4 alkyl), SO 2 NHSO 2 (CH 2) 2-3 CF 3, N(C 1-4 alkyl)SO 2 NH 2, N(CO 2 C 1-4 alkyl)SO 2 (C 1-4 alkyl), and R 6 is independently selected from the group consisting of: R a is, independently at each occurrence, selected from the group consisting of: halogen, C 1-6 alkyl substituted with 0-1 OH, C 1-4 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, OH, CN, NO 2, NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), CONH 2, CONH(C 1-4 alkyl), SO 2 NH 2, SO 2 N(C 1-4 alkyl) 2, CONH(CH 2) 1-3 CF 3, pyrazolyl, and R b is, independently at each occurrence, selected from the group consisting of: halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, OH, CN, NH 2, NO 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 H, CO 2 (C 1-4 alkyl), SO 2 (C 1-4 alkyl), SO 2 NH 2, CONH 2, and CONH(C 1-4 alkyl); R c is, independently at each occurrence, selected from the group consisting of: H, C 1-6 alkyl, CO(C 1-4 alkyl), CO 2 (C 1-4 alkyl), COBn, CO 2 Bn, pyrimidinyl and -(CH 2) t -(C 3-6 carbocycle substituted with 0-2 R e); R e is, independently at each occurrence, selected from the group consisting of: halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, and C 1-4 haloalkoxy; m and t are, independently at each occurrence, selected from 0, 1, 2, and 3; and p is, independently at each occurrence, selected from 0, 1, and 2; and s is, independently at each occurrence, selected from 1, 2, and 3.