mhurhangee/ep-ind-claims huggingface dataset:
A compound represented by formula, stereoisomer thereof or pharmaceutically acceptable salt thereof: wherein R 1 is selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, -COR 5, -SO 2 R 5 or -SOR 5, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, -NR 6 R 8, -NR 6 COR 7, -COR 7, -SO 2 R 7, -SOR 7, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, or a 4-10 membered heterocyclic group; R 2 and R 4 are each independently selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl or C 2 -C 8 alkynyl, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, -NR 6 R 8, -NR 6 COR 5, -COR 5, -SO 2 R 5, -SOR 5, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, or a 4-10 membered heterocyclic group; R 5 and R 7 are each independently selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or -NR 8; R 6 and R 8 are each independently selected from H, C 1 -C 8 alkyl, or C 3 -C 8 cycloalkyl; Y is -(CH 2) n - or -O(CH 2) n -; n is selected from 0, 1, 2 or 3; alternatively, any two of R 1, R 2 and R 4 can independently form a C 3 -C 8 cycloalkyl group, or a 4-10 membered heterocyclic group; R 3 is selected from H, deuterium, halogen, cyano, nitro, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or C 1 -C 8 alkoxy; and X is selected from CH or N. wherein R 1 is selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, -COR 5, -SO 2 R 5 or -SOR 5, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, -NR 6 R 8, -NR 6 COR 7, -COR 7, -SO 2 R 7, -SOR 7, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, or a 4-10 membered heterocyclic group; R 2 and R 4 are each independently selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 alkenyl or C 2 -C 8 alkynyl, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, nitro, -NR 6 R 8, -NR 6 COR 5, -COR 5, -SO 2 R 5, -SOR 5, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 8 alkoxy, or a 4-10 membered heterocyclic group; R 5 and R 7 are each independently selected from H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or -NR 8; R 6 and R 8 are each independently selected from H, C 1 -C 8 alkyl, or C 3 -C 8 cycloalkyl; Y is -(CH 2) n - or -O(CH 2) n -; n is selected from 0, 1, 2 or 3; alternatively, any two of R 1, R 2 and R 4 can independently form a C 3 -C 8 cycloalkyl group, or a 4-10 membered heterocyclic group; R 3 is selected from H, deuterium, halogen, cyano, nitro, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, or C 1 -C 8 alkoxy; and X is selected from CH or N.
A system for manufacturing at least one structural thermoplastic piece, for being integrated into a primary structure of a plane, said structural thermoplastic piece being formed from a blank comprising reinforcing fibres embedded in a thermoplastic matrix, the structural thermoplastic piece to be manufactured comprising an external face and an internal face, opposite to the external face, the manufacturing system comprising: - a first mould, comprising an internal cavity for forming the external face of the thermoplastic piece to be manufactured, - a first counter-mould comprising an external cavity for forming the internal face of the thermoplastic piece to be manufactured, the blank being to be mounted between the first mould and the first counter-mould, - a second mould configured to be mounted facing the first mould, - a device for closing the moulds (2, 2') so as to prohibit spacing thereof, - a device for heating the blank to a heating temperature greater than the melting temperature of the thermoplastic matrix so as to make it malleable, - at least one inflatable pressure member made of a material having a thermal resistance greater than the heating temperature, the inflatable pressure member being mounted between the first counter-mould and the second mould, - the inflatable pressure member being configured to move between a deflated rest state and an inflated stress state in which the inflatable pressure member is configured to press the blank between the cavity of the first mould and the cavity of the first counter-mould so as to strengthen the blank and form the structural thermoplastic piece. - a first mould, comprising an internal cavity for forming the external face of the thermoplastic piece to be manufactured, - a first counter-mould comprising an external cavity for forming the internal face of the thermoplastic piece to be manufactured, the blank being to be mounted between the first mould and the first counter-mould, - a second mould configured to be mounted facing the first mould, - a device for closing the moulds (2, 2') so as to prohibit spacing thereof, - a device for heating the blank to a heating temperature greater than the melting temperature of the thermoplastic matrix so as to make it malleable, - at least one inflatable pressure member made of a material having a thermal resistance greater than the heating temperature, the inflatable pressure member being mounted between the first counter-mould and the second mould, - the inflatable pressure member being configured to move between a deflated rest state and an inflated stress state in which the inflatable pressure member is configured to press the blank between the cavity of the first mould and the cavity of the first counter-mould so as to strengthen the blank and form the structural thermoplastic piece.
An aircraft including a body and a wing projecting from the body to a spiroid wing tip coupled to the end of the wing remote from the body, the spiroid wing-tip exhibiting an enclosed loop that comprises: a first generally planar section (A-B) coupled to an end of the wing; a second generally planar section (B-C) coupled to the first generally planar section extending generally away from the body of the aircraft; a third generally planar section (C-D) coupled to the second generally planar section; a fourth generally planar section (D-E) coupled to the third generally planar section; extending generally toward the body of the aircraft; and a fifth generally planar section (E-F) coupled to the fourth generally planar section and the end of the wing; wherein the leading edge of the wing is continuous with a leading edge of the first section and the trailing edge of the wing is continuous with a trailing edge of the fifth section; and characterized in that a trailing edge of the first section emanates from a lower surface of the fifth section and a leading edge of the fifth section emanates from an upper surface of the first section whereby the spiroid loop is closed by an overlap of the loop ends in an offset configuration as seen from above. a first generally planar section (A-B) coupled to an end of the wing; a second generally planar section (B-C) coupled to the first generally planar section extending generally away from the body of the aircraft; a third generally planar section (C-D) coupled to the second generally planar section; a fourth generally planar section (D-E) coupled to the third generally planar section; extending generally toward the body of the aircraft; and a fifth generally planar section (E-F) coupled to the fourth generally planar section and the end of the wing; wherein the leading edge of the wing is continuous with a leading edge of the first section and the trailing edge of the wing is continuous with a trailing edge of the fifth section; and characterized in that a trailing edge of the first section emanates from a lower surface of the fifth section and a leading edge of the fifth section emanates from an upper surface of the first section whereby the spiroid loop is closed by an overlap of the loop ends in an offset configuration as seen from above.
A medical device, comprising: an outer cannula including a cutting window; an inner cannula disposed within the outer cannula; a flexible outer tubing coupled to a proximal end of the outer cannula; a coupling member having a distal end coupled to the proximal end of the inner cannula; and an aspiration tubing disposed within an inner wall of the flexible outer tubing and fluidly coupled to the inner cannula via the coupling member, and a rotary seal including an inner ring connected to an outer ring, the inner ring including a stationary portion and a rotational portion, the rotational portion coupled to the coupling member and the stationary portion coupled to the aspiration tubing, the rotary seal configured to cause the coupling member to rotate relative to the aspiration tubing responsive to actuation of a corresponding coupling component. an outer cannula including a cutting window; an inner cannula disposed within the outer cannula; a flexible outer tubing coupled to a proximal end of the outer cannula; a coupling member having a distal end coupled to the proximal end of the inner cannula; and an aspiration tubing disposed within an inner wall of the flexible outer tubing and fluidly coupled to the inner cannula via the coupling member, and a rotary seal including an inner ring connected to an outer ring, the inner ring including a stationary portion and a rotational portion, the rotational portion coupled to the coupling member and the stationary portion coupled to the aspiration tubing, the rotary seal configured to cause the coupling member to rotate relative to the aspiration tubing responsive to actuation of a corresponding coupling component.
TETRA common-wave radio network device comprising a central TETRA control unit and at least two radio cell units, where the radio cell units are connected to the control unit via a wired communication link for synchronized emission of at least one HF reception signal of a TETRA terminal received from at least one radio cell unit, where each radio cell unit comprises a Tx IF/HF converter and an Rx HF/IF converter separate from it, to convert TETRA HF signals received via an antenna network into IF communication signals and vice versa, characterized in that the control unit comprises at least one separate Rx IF/HF converter and one separate Tx HF/IF converter, to convert IF communication signals into TETRA HF signals and vice versa, and a TETRA DMO repeater and/or a TETRA base station which evaluates a received TETRA Rx signal in the IF band after the Rx IF/HF converter and emits it as a TETRA Tx signal via the Tx HF/IF converter for common-wave broadcasting to all radio cell units.
A flosser with a grip body, with a holder which is connected to the grip body and has a first and a second holder arm (6a, 6b), and with an interdental space cleaning element which is fastened to the first and second holder arm and extends between the two holder arms, and the flosser in the grip body comprises a toothpick, wherein the grip body forms two arm sections which form an intermediate space and the intermediate space receives the toothpick in a passive position, and the flosser with the grip body is designed in a flat manner and the toothpick in the passive position lies in a plane with the grip body, characterised in that a pivotable part of the grip body which can be pivoted away and which is designed as a protective part can be pivoted away with a pivoting angle of 180° via a film hinge which is arranged in the grip body, so that the toothpick can be exposed out of the grip body, wherein the protective part forms a protection for the toothpick in the passive position, and the protective part in a function position, in which the toothpick is exposed out of the grip body, is fixed by way of one or more connection means, wherein the connection means are designed for forming a positive connection, and a first connection means comprises a recess or an opening and a second connection means a prominence in the form of a nub or pin.
A downforce system (102, 202, 1902, 2302) for a vehicle (100, 200, 1600, 1700, 1800, 1900, 2200, 2300), the downforce system comprising: a restrictor (104, 401, 501, 702, 902, 1102, 1502, 1602, 1702a, 1702b, 1802, 1904, 2304) configured to restrict a flow of air into a region that is defined at least in part by the restrictor and a ground surface on which the vehicle is disposed, a rim (108, 412, 512, 700, 900, 1000, 1100, 1608, 1704a, 1704b, 1804, 1912, 2305) disposed on the restrictor and configured to form at least a partial seal with the ground surface, wherein the rim is disposed at or near a lower edge of the restrictor, and wherein the rim includes a portion (414, 514, 706, 906, 1106) that extends outwards from the lower edge of the restrictor, such that the portion of the rim is substantially parallel to the ground surface; a dedicated pressure source disposed outside the restrictor and connected to the restrictor via an air flow path (114, 116), the pressure source being configured to generate a pressure differential across the restrictor; and a dust and debris removal system (112, 1200, 1300, 1400) configured to prevent dust and debris from exiting the downforce system via the air flow path. a restrictor (104, 401, 501, 702, 902, 1102, 1502, 1602, 1702a, 1702b, 1802, 1904, 2304) configured to restrict a flow of air into a region that is defined at least in part by the restrictor and a ground surface on which the vehicle is disposed, a rim (108, 412, 512, 700, 900, 1000, 1100, 1608, 1704a, 1704b, 1804, 1912, 2305) disposed on the restrictor and configured to form at least a partial seal with the ground surface, wherein the rim is disposed at or near a lower edge of the restrictor, and wherein the rim includes a portion (414, 514, 706, 906, 1106) that extends outwards from the lower edge of the restrictor, such that the portion of the rim is substantially parallel to the ground surface; a dedicated pressure source disposed outside the restrictor and connected to the restrictor via an air flow path (114, 116), the pressure source being configured to generate a pressure differential across the restrictor; and a dust and debris removal system (112, 1200, 1300, 1400) configured to prevent dust and debris from exiting the downforce system via the air flow path.
A drive circuit for providing a drive signal for a switch in a switching converter, the drive circuit comprising: an output terminal for providing the drive signal; a soft-start terminal for applying a soft-start signal (Vs) thereto; a feedback terminal for applying a feedback signal thereto; the drive circuit being capable of assuming one of the following operation states: a latch-off mode in which the drive circuit is deactivated; a normal operation mode, in which a duration of drive pulses of the drive signal is dependent on the feedback signal; a soft-start mode, in which a duration of drive pulses of the drive signal is dependent on a voltage (Vs) at the soft-start terminal; wherein the drive circuit is adapted to assume the latch-off mode dependent on the voltage (Vs) at the soft-start terminal, and is adapted to leave the latch-off mode only when a supply voltage (Vcc) received at a supply terminal of the drive circuit falls below a reference value. an output terminal for providing the drive signal; a soft-start terminal for applying a soft-start signal (Vs) thereto; a feedback terminal for applying a feedback signal thereto; a latch-off mode in which the drive circuit is deactivated; a normal operation mode, in which a duration of drive pulses of the drive signal is dependent on the feedback signal; a soft-start mode, in which a duration of drive pulses of the drive signal is dependent on a voltage (Vs) at the soft-start terminal; wherein the drive circuit is adapted to assume the latch-off mode dependent on the voltage (Vs) at the soft-start terminal, and is adapted to leave the latch-off mode only when a supply voltage (Vcc) received at a supply terminal of the drive circuit falls below a reference value.
An apparatus comprising: a flying boom adapted to refuel aircraft in flight, the flying boom including: a refueling tube that is adapted to extend from an end of the flying boom to refuel receptacle-equipped aircraft; a retractable hose and drogue assembly that is adapted to extend from the end of the flying boom to refuel probe-equipped aircraft; a first channel within the flying boom that includes the refueling tube; a second channel within the flying boom that includes the hose and drogue assembly; and a hose reel coupled with the hose and drogue assembly that is adapted to rotate and deploy the hose and drogue assembly from the end of the flying boom to refuel the probe-equipped aircraft, and wherein: the hose reel is further adapted to rotate and retract the hose and drogue assembly into the end of the flying boom. a refueling tube that is adapted to extend from an end of the flying boom to refuel receptacle-equipped aircraft; a retractable hose and drogue assembly that is adapted to extend from the end of the flying boom to refuel probe-equipped aircraft; a first channel within the flying boom that includes the refueling tube; a second channel within the flying boom that includes the hose and drogue assembly; and a hose reel coupled with the hose and drogue assembly that is adapted to rotate and deploy the hose and drogue assembly from the end of the flying boom to refuel the probe-equipped aircraft, and wherein: the hose reel is further adapted to rotate and retract the hose and drogue assembly into the end of the flying boom.
A bicycle trainer, comprising: a frame that can support a bicycle in a generally stationary position while a user exerts a pedaling effort to rotate a driven wheel with a tire of the bicycle during a training session; and a resistance unit that is supported by the frame and that is configured to cooperate in use with the tire of the driven wheel of the bicycle so as to resist the pedaling effort of the user, the resistance unit being movable in a tightening direction in which the resistance unit is moveable toward the driven wheel and in a loosening direction in which the resistance unit is moveable away from the driven wheel, wherein the resistance unit includes a roller which is mounted in a position with respect to the frame such that the roller is configured to engage the tire which is mounted to the driven wheel at a contact location and wherein the resistance unit is supported from the frame at a support location by a hinge with a pivot axis, wherein said pivot axis is positioned above and behind the contact location between the roller and the tire such that when a torque that rotates the driven wheel is applied the resistance unit automatically pivots towards the driven wheel thus increasing a normal force between the resistance unit and the driven wheel. a frame that can support a bicycle in a generally stationary position while a user exerts a pedaling effort to rotate a driven wheel with a tire of the bicycle during a training session; and a resistance unit that is supported by the frame and that is configured to cooperate in use with the tire of the driven wheel of the bicycle so as to resist the pedaling effort of the user, the resistance unit being movable in a tightening direction in which the resistance unit is moveable toward the driven wheel and in a loosening direction in which the resistance unit is moveable away from the driven wheel, wherein the resistance unit includes a roller which is mounted in a position with respect to the frame such that the roller is configured to engage the tire which is mounted to the driven wheel at a contact location and wherein the resistance unit is supported from the frame at a support location by a hinge with a pivot axis, wherein said pivot axis is positioned above and behind the contact location between the roller and the tire such that when a torque that rotates the driven wheel is applied the resistance unit automatically pivots towards the driven wheel thus increasing a normal force between the resistance unit and the driven wheel.
Device for sampling, in particular for withdrawing samples from free-flowing and/or liquid and/or gaseous material, comprising a housing having a housing chamber which has two connection openings, spaced apart from one another, for connecting in each case a line portion through which a material flow may flow, the two connection openings in particular having identical opening cross-sections, and the device including a withdrawal element which is movable in the housing chamber, the withdrawal element being formed, at least in portions, in a profile-like manner, the withdrawal element bounding a hollow sampling region, extending along a profile longitudinal direction course, at the periphery of the sampling region, while leaving an entry opening which in particular is slit-like and which extends along an opening longitudinal direction course, guide means being provided by means of which a defined movement pattern of the withdrawal element in the housing chamber is predetermined, via which movement pattern at least one of the two opening cross-sections in a projection view perpendicular thereto may be traversed over the entire area by means of the entry opening, as a result of the movement pattern specified by the guide means, an orientation of the withdrawal element in an observation plane which moves with the withdrawal element relative to a geometric intersection line of the observation plane with a nonmoving geometric reference plane which extends perpendicular to the observation plane and to at least one opening cross-section, remaining the same when the withdrawal element is moved, characterized in that the opening longitudinal direction course of the withdrawal element extends, in particular in an even manner, along a geometric spherical surface, and that a movement path or movement pattern of the withdrawal element extends geometrically in a circular direction about a rotational axis.
A wireless communication station comprising: a plurality of antennas configured to receive and transmit wireless signals between the wireless communication station and at least two other devices; a transceiver coupled to said plurality of antennas, said transceiver being MIMO compatible and spectrum aggregation compatible; and a controller that is triggered to switch between a MIMO mode of operation and a spectrum aggregation mode of operation, based on a level of detected channel usage; characterized in that said wireless communication station is a relay node, said relay node being configured to communicate with different base stations using different communication modes of operation than a communication mode used by the relay node to communicate with a user equipment. a plurality of antennas configured to receive and transmit wireless signals between the wireless communication station and at least two other devices; a transceiver coupled to said plurality of antennas, said transceiver being MIMO compatible and spectrum aggregation compatible; and a controller that is triggered to switch between a MIMO mode of operation and a spectrum aggregation mode of operation, based on a level of detected channel usage; characterized in that said wireless communication station is a relay node, said relay node being configured to communicate with different base stations using different communication modes of operation than a communication mode used by the relay node to communicate with a user equipment.
A method for cleaning objects stacked in the manner of a stack, for example trays, more particularly trays for eggs or food products as fruit or vegetables, comprising: - providing a stack of objects stacked into each other; - setting said stack in falling motion, wherein the falling stack comes down into a cleaning liquid; and - passing this stack through the cleaning liquid. - providing a stack of objects stacked into each other; - setting said stack in falling motion, wherein the falling stack comes down into a cleaning liquid; and - passing this stack through the cleaning liquid.