mhurhangee/ep-ind-claims huggingface dataset:
A method of mutagenesis of a parent nucleic acid encoding a protein to generate modified proteins, said method comprising: (a.) obtaining a primer set comprising primers that each comprise at least one 2 to 12 fold degenerate codon, wherein each primer comprises at least two oligonucleotide sequences that are complementary to a sequence in the parent nucleic acid, and wherein the degenerate codons non-redundantly code for an equal representation of eighteen amino acid substitutions with the exception of cysteine or methionine at each of one or more amino acid position(s) encoded by the parent nucleic acid; and (b.) mutating the parent nucleic acid by replication or polymerase based amplification using the primer set obtained in (a), wherein replication or amplification of the parent nucleic acid with the primers generate mutated nucleic acids that encode said equal representation of eighteen amino acid substitutions in modified proteins. (a.) obtaining a primer set comprising primers that each comprise at least one 2 to 12 fold degenerate codon, wherein each primer comprises at least two oligonucleotide sequences that are complementary to a sequence in the parent nucleic acid, and wherein the degenerate codons non-redundantly code for an equal representation of eighteen amino acid substitutions with the exception of cysteine or methionine at each of one or more amino acid position(s) encoded by the parent nucleic acid; and (b.) mutating the parent nucleic acid by replication or polymerase based amplification using the primer set obtained in (a), wherein replication or amplification of the parent nucleic acid with the primers generate mutated nucleic acids that encode said equal representation of eighteen amino acid substitutions in modified proteins.
An induction heating unit for heating a conductive heat-producing rotating body through electromagnetic induction to thermally fix a toner image onto a recording sheet in one of a plurality of sizes, said induction heating unit, comprising: a) a magnetising coil to be arranged along an outer circumferential surface of the heat-producing rotating body for heating the heat-producing rotating body through electromagnetic induction heating; and b) a demagnetising coil arranged in partially-overlapping proximity to the magnetising coil and partially cancelling out magnetic flux produced by the magnetising coil to suppress overheating in a non-sheet-passing region of the heat-producing rotating body when fixing is performed on a recording sheet in one of the sizes that is not a largest size, characterised in that c) the demagnetising coil includes a coil pattern printed on a flexible substrate, and the coil pattern has a wire of greater width (Wp) than the separation (Wc) between neighbouring portions of the wire; and d) the demagnetising coil includes a plurality of overlaid flexible substrates, each having the coil pattern printed thereon. a) a magnetising coil to be arranged along an outer circumferential surface of the heat-producing rotating body for heating the heat-producing rotating body through electromagnetic induction heating; and b) a demagnetising coil arranged in partially-overlapping proximity to the magnetising coil and partially cancelling out magnetic flux produced by the magnetising coil to suppress overheating in a non-sheet-passing region of the heat-producing rotating body when fixing is performed on a recording sheet in one of the sizes that is not a largest size, characterised in that c) the demagnetising coil includes a coil pattern printed on a flexible substrate, and the coil pattern has a wire of greater width (Wp) than the separation (Wc) between neighbouring portions of the wire; and d) the demagnetising coil includes a plurality of overlaid flexible substrates, each having the coil pattern printed thereon.
A method for determining fish gender, readiness for breeding, or readiness for roe harvesting, which method comprises collecting blood from fish; optionally separating serum or plasma from such blood; measuring the concentration in such serum, plasma or blood of one or more peptide hormones of the transforming growth factor-beta superfamily (TGF-β superfamily); and determining fish gender, readiness for breeding, or readiness for roe harvesting based on such peptide hormone concentration.
An apparatus for cutting human or animal tissue, such as a cornea, or a lens, said apparatus including a femtosecond laser capable of emitting a laser beam in the form of pulses and a device for processing the laser beam generated by the femtosecond laser, the processing device being positioned downstream of said femtosecond laser, the processing device comprising: - a shaping system positioned on the trajectory of said beam, the shaping system including a spatial light modulator programmed using at least one phase mask to modulate the phase of the wavefront of the laser beam so as to obtain a modulated laser beam, - a sweeping optical scanner downstream of the shaping system, - an optical focusing system downstream of the sweeping optical system, the focusing optical system comprising a concentrator module for focusing the phase-modulated laser beam in a focusing plane and a depth positioning module for moving the focusing plane into a plurality of cutting planes. - a shaping system positioned on the trajectory of said beam, the shaping system including a spatial light modulator programmed using at least one phase mask to modulate the phase of the wavefront of the laser beam so as to obtain a modulated laser beam, - a sweeping optical scanner downstream of the shaping system, - an optical focusing system downstream of the sweeping optical system, the focusing optical system comprising a concentrator module for focusing the phase-modulated laser beam in a focusing plane and a depth positioning module for moving the focusing plane into a plurality of cutting planes.
An information sending method, comprising: sending, by a controller, a forwarding indication message to a forwarder, being configured to perform packet forwarding according to a forwarding indication message sent by the controller, wherein: the forwarding indication message comprises at least two routing correspondences and a tunnel correspondence, the at least two routing correspondences comprise a first routing correspondence and a second routing correspondence, the first routing correspondence is mapping of a first route to a next hop identifier, the second routing correspondence is mapping of a second route to the next hop identifier, and the first route is different from the second route; and wherein the tunnel correspondence is a correspondence of the next hop identifier to multiple public network tunnels. sending, by a controller, a forwarding indication message to a forwarder, being configured to perform packet forwarding according to a forwarding indication message sent by the controller, wherein: the forwarding indication message comprises at least two routing correspondences and a tunnel correspondence, the at least two routing correspondences comprise a first routing correspondence and a second routing correspondence, the first routing correspondence is mapping of a first route to a next hop identifier, the second routing correspondence is mapping of a second route to the next hop identifier, and the first route is different from the second route; and wherein the tunnel correspondence is a correspondence of the next hop identifier to multiple public network tunnels.
A laser output measuring apparatus comprising: a lens that converges a laser beam incident thereon; an optical separator that reflects a part of the laser beam converged by the lens according to a Fresnel reflectivity that depends on a polarization direction and an incident angle thereon of the laser beam; a photodetector that measures an intensity of the laser beam reflected by the optical separator, a first angle adjusting mechanism that rotates the optical separator by a predetermined angle about an optical axis of the laser beam converged by the lens, and a second angle adjusting mechanism that rotates the optical separator by a predetermined angle about the straight line perpendicular to the optical axis of the laser beam and the incident surface of the laser beam. a lens that converges a laser beam incident thereon; an optical separator that reflects a part of the laser beam converged by the lens according to a Fresnel reflectivity that depends on a polarization direction and an incident angle thereon of the laser beam; a photodetector that measures an intensity of the laser beam reflected by the optical separator, a first angle adjusting mechanism that rotates the optical separator by a predetermined angle about an optical axis of the laser beam converged by the lens, and a second angle adjusting mechanism that rotates the optical separator by a predetermined angle about the straight line perpendicular to the optical axis of the laser beam and the incident surface of the laser beam.
A trigger assembly for use with a power tool having an electric motor, the trigger assembly comprising: a trigger; a conductor coupled for movement with the trigger; a printed circuit board having an inductive sensor thereon responsive to relative movement between the conductor and the inductive sensor caused by movement of the trigger; the inductive sensor being a coil trace having a first end and a second end that has a different coil density than the first end; and a spring biasing the trigger to a position in which the conductor is located in a neutral position between the first end and the second end, wherein, in response to the conductor moving away from the neutral position and towards the first end of the coil trace, the output of the inductive sensor is used to activate the motor in a first rotational direction and to accelerate a rotational speed of the motor, and wherein, in response to the conductor moving away from the neutral position and towards the second end of the coil trace, the output of the inductive sensor is used to activate the motor in an opposite, second rotational direction and to accelerate a rotational speed of the motor. a trigger; a conductor coupled for movement with the trigger; a printed circuit board having an inductive sensor thereon responsive to relative movement between the conductor and the inductive sensor caused by movement of the trigger; the inductive sensor being a coil trace having a first end and a second end that has a different coil density than the first end; and a spring biasing the trigger to a position in which the conductor is located in a neutral position between the first end and the second end, wherein, in response to the conductor moving away from the neutral position and towards the first end of the coil trace, the output of the inductive sensor is used to activate the motor in a first rotational direction and to accelerate a rotational speed of the motor, and wherein, in response to the conductor moving away from the neutral position and towards the second end of the coil trace, the output of the inductive sensor is used to activate the motor in an opposite, second rotational direction and to accelerate a rotational speed of the motor.
A shoe with an internal ventilation system, comprising: - an upper; - a ventilation chamber; - a sole composing an unbroken whole with said shoe, said sole being obtained through the injection or pouring of plastic material into a closed mould, directly onto said upper; - a non-return valve (5, 5a) connected inside said sole with said ventilation chamber, said non-return valve having been prepared and provided in said mould or inserted subsequently in the sole previously moulded with adequate housing for the valve in mind; - an insole with ventilation holes on its surface; characterized in that said ventilation chamber is isolated with nonabsorbent material on its side that touches the sole, is glued onto the upper surface with said insole and is composed of spongy, open cell material, being the cells which form said open cell material in communication with one another. - an upper; - a ventilation chamber; - a sole composing an unbroken whole with said shoe, said sole being obtained through the injection or pouring of plastic material into a closed mould, directly onto said upper; - a non-return valve (5, 5a) connected inside said sole with said ventilation chamber, said non-return valve having been prepared and provided in said mould or inserted subsequently in the sole previously moulded with adequate housing for the valve in mind; - an insole with ventilation holes on its surface;
A method for producing a book-like identification, value or security document, the identification, value or security document comprising a cover as well as a passport book block comprising a data card, a plurality of double pages, an endpaper and a spine tape, the data card comprising a flexible tab connected along an edge to the data card, the data card comprising the flexible tab, the double pages, the endpaper and the spine tape being sewn together by way of a seam, and the cover with an inner side being adhesively bonded in a planar manner to an outer side of the endpaper, the method comprising the following steps: - providing the passport book block; - providing the cover, characterized in that the method additionally comprises the following steps: - providing an adhesive layer, in particular an adhesive tape, the adhesive layer being applied to a backing film, the adhesive layer having an activation temperature at which the adhesive layer develops adhesive properties, as well as a curing temperature at which the adhesive layer cross-links and cures, the curing temperature being higher than the activation temperature; - heating the adhesive layer, in particular to the activation temperature; - applying the adhesive layer to the inner side of the cover, the adhesive layer adhering to the inner side of the cover, and detaching the adhesive layer from the backing film; - connecting the cover and the passport book block to form a passport book blank, the outer side of the endpaper being placed onto the inner side of the cover; - folding the passport book blank; - subsequently heating the adhesive layer to the curing temperature; and - fixing the passport book blank in the folded state until the adhesive layer has cured and an integral and/or form-fit connection is established between the cover and the endpaper. - providing the passport book block; - providing the cover, - providing an adhesive layer, in particular an adhesive tape, the adhesive layer being applied to a backing film, the adhesive layer having an activation temperature at which the adhesive layer develops adhesive properties, as well as a curing temperature at which the adhesive layer cross-links and cures, the curing temperature being higher than the activation temperature; - heating the adhesive layer, in particular to the activation temperature; - applying the adhesive layer to the inner side of the cover, the adhesive layer adhering to the inner side of the cover, and detaching the adhesive layer from the backing film; - connecting the cover and the passport book block to form a passport book blank, the outer side of the endpaper being placed onto the inner side of the cover; - folding the passport book blank; - subsequently heating the adhesive layer to the curing temperature; and - fixing the passport book blank in the folded state until the adhesive layer has cured and an integral and/or form-fit connection is established between the cover and the endpaper.
An apparatus, comprising: a processing unit; memory storing instructions operable on the processing unit, the instructions, when executed, cause the processing unit to: provide for transmission of a neighbor awareness networking, NAN, synchronization beacon frame to keep devices in synchronization in a NAN, the NAN synchronization beacon comprising an organizationally unique identifier, OUI, field, an OUI type field, a NAN identification field, a timestamp field and a field comprising an indication of an interval between discovery windows, the OUI field comprising a Wi-Fi alliance, WFA, specific OUI, the OUI type field comprising a type and version of the NAN, the timestamp field comprising value of a timing synchronization function, TSF, timer of a source of the NAN synchronization beacon frame, and the NAN identification field comprising an identifier of the NAN; and cause transmission of the NAN synchronization beacon frame. a processing unit; memory storing instructions operable on the processing unit, the instructions, when executed, cause the processing unit to: provide for transmission of a neighbor awareness networking, NAN, synchronization beacon frame to keep devices in synchronization in a NAN, the NAN synchronization beacon comprising an organizationally unique identifier, OUI, field, an OUI type field, a NAN identification field, a timestamp field and a field comprising an indication of an interval between discovery windows, the OUI field comprising a Wi-Fi alliance, WFA, specific OUI, the OUI type field comprising a type and version of the NAN, the timestamp field comprising value of a timing synchronization function, TSF, timer of a source of the NAN synchronization beacon frame, and the NAN identification field comprising an identifier of the NAN; and cause transmission of the NAN synchronization beacon frame. provide for transmission of a neighbor awareness networking, NAN, synchronization beacon frame to keep devices in synchronization in a NAN, the NAN synchronization beacon comprising an organizationally unique identifier, OUI, field, an OUI type field, a NAN identification field, a timestamp field and a field comprising an indication of an interval between discovery windows, the OUI field comprising a Wi-Fi alliance, WFA, specific OUI, the OUI type field comprising a type and version of the NAN, the timestamp field comprising value of a timing synchronization function, TSF, timer of a source of the NAN synchronization beacon frame, and the NAN identification field comprising an identifier of the NAN; and cause transmission of the NAN synchronization beacon frame.
A mixture of powders for preparing a sintered nickel-titanium-rare earth (Ni-Ti-RE) alloy, the mixture being a mixture of: a Ni-Ti alloy powder consisting of from 55 wt.% Ni to 61 wt.% Ni and from 39 wt.% Ti to 45 wt.% Ti and incidental impurities, wherein the Ni-Ti alloy powder consists of a mixture of a first binary alloy powder and a second binary alloy powder where the first binary alloy powder comprises 54-58 wt.% Ni and 42-46 wt.% Ti, and the second binary alloy powder comprises 58-62 wt.% Ni and 38-42 wt.% Ti; and a rare earth alloy powder consisting of a rare earth element selected from the group consisting of La, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, and at least one additional element, the additional element being a dopant or additional alloying element selected from the group consisting of B, Al, Cr, Mn, Fe, Ni, Co, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Sb, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Po, V, other rare earth elements, and Y up to a concentration of no more than 50 wt.% of the rare earth alloy powder, and incidental impurities; wherein the weight ratio of the Ni-Ti alloy powder to the rare earth alloy powder is at least 60:40 and no more than 90:10. a Ni-Ti alloy powder consisting of from 55 wt.% Ni to 61 wt.% Ni and from 39 wt.% Ti to 45 wt.% Ti and incidental impurities, wherein the Ni-Ti alloy powder consists of a mixture of a first binary alloy powder and a second binary alloy powder where the first binary alloy powder comprises 54-58 wt.% Ni and 42-46 wt.% Ti, and the second binary alloy powder comprises 58-62 wt.% Ni and 38-42 wt.% Ti; and a rare earth alloy powder consisting of a rare earth element selected from the group consisting of La, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, and at least one additional element, the additional element being a dopant or additional alloying element selected from the group consisting of B, Al, Cr, Mn, Fe, Ni, Co, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Sb, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Po, V, other rare earth elements, and Y up to a concentration of no more than 50 wt.% of the rare earth alloy powder, and incidental impurities; wherein the weight ratio of the Ni-Ti alloy powder to the rare earth alloy powder is at least 60:40 and no more than 90:10.
An apparatus for cutting human or animal tissue, such as a cornea, or a lens, said apparatus including a femtosecond laser capable of emitting a laser beam in the form of pulses and a processing device for producing a pattern composed of at least two impact points in a focusing plane from the laser beam generated by the femtosecond laser, the processing device being positioned downstream of said femtosecond laser, the processing device comprising: - a shaping system for modulating the phase of the wavefront of the laser beam generated by the femtosecond laser so as to obtain a single phase-modulated laser beam according to a modulation set value calculated to distribute the energy of the laser beam in at least two impact points forming the pattern in its focal plane, - an optical focusing system for focusing the single modulated laser beam in a cutting plane, the shaping system being positioned between the femtosecond laser and the optical focusing system, and - a control unit capable of controlling the movement of the optical focusing system along an optical path of the laser beam to displace the focusing plane into at least three respective cutting planes so as to form a stack of tissue cutting surfaces, characterized in that the laser beam is a single beam upstream and downstream of the shaping system, and the control unit is capable of controlling the movement of the optical focusing system to move the focusing plane between an initial position and a final position in that order, the final position being closer to the femtosecond laser than the initial position. - a shaping system for modulating the phase of the wavefront of the laser beam generated by the femtosecond laser so as to obtain a single phase-modulated laser beam according to a modulation set value calculated to distribute the energy of the laser beam in at least two impact points forming the pattern in its focal plane, - an optical focusing system for focusing the single modulated laser beam in a cutting plane, the shaping system being positioned between the femtosecond laser and the optical focusing system, and - a control unit capable of controlling the movement of the optical focusing system along an optical path of the laser beam to displace the focusing plane into at least three respective cutting planes so as to form a stack of tissue cutting surfaces,
A process for the preparation of enantiomerically pure nicotine by the resolution of (R,S)-nicotine by diastereomeric salt formation using enantiomerically pure dibenzoyl tartaric acid as the resolving agent, said process comprising: (a) dissolving (R, S)-nicotine in a polar solvent or a mixture of polar solvents and treating with enantiomerically pure dibenzoyl tartaric acid, (b) filtering the precipitated salt of nicotine dibenzoyl tartrate, (c) hydrolyzing the salt using either an acid or a base, (d) extracting enantiomerically pure nicotine from the hydrolyzed reaction mixture with an organic solvent immiscible with water, wherein in step (a), the polar solvent is ethanol or acetone, or a mixture of isopropanol and methanol is used and the volume:volume ratio of isopropranol:methanol is between 1.0:0.20 and 1.0:0.80. (a) dissolving (R, S)-nicotine in a polar solvent or a mixture of polar solvents and treating with enantiomerically pure dibenzoyl tartaric acid, (b) filtering the precipitated salt of nicotine dibenzoyl tartrate, (c) hydrolyzing the salt using either an acid or a base, (d) extracting enantiomerically pure nicotine from the hydrolyzed reaction mixture with an organic solvent immiscible with water,