mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula I, wherein: R is C 1-6 alkyl or n is 0 or 1 R 1 is absent, halo, cyano, C 1-6 alkyl, or -C(=O)N(CH 3) 2; R 2 is absent, halo, cyano, -C(=O)NH 2, or -C(=O)N(CH 3) 2; R 3 is halo or -C(=O)R 3a, R 3a is R 3a' or R 3a"; R 3a' is heterocycloalkyl, optionally substituted with C 1-6 alkyl, amino, C 1-10 alkyl amino, di C 1-10 alkyl amino, or N(CH 3)C(=O)OC(CH 3) 3; R 3a" is -OR 3b, NH(CH 2) 2 R 3c; NHCN, NHS(=O) 2 R 3d, or NHR 3e; R 3b is H or C 1-6 alkyl; R 3c is C 1-6 alkoxy, amino, C 1-10 alkyl amino or di C 1-10 alkyl amino; R 3d is C 1-6 alkyl or cycloalkyl; R 3e is heterocycloalkyl, C 1-6 alkyl heterocycloalkyl, or (CH 2) 2 N(CH 3)C(=O)OC(CH 3) 3; R 4 is absent, C 1-6 alkyl, C 1-6 alkoxy, cyano, hydroxy, or halo; R 5 is halo or C 1-6 alkyl; R 6 is absent, halo, C 1-6 alkyl, or C 1-6 alkoxy; R 7 is H or R 7 and R 4 come together to form -C(=O)-; R 8 is absent, C 1-6 alkyl, hydroxy, or halo; R 9 is absent or halo; X is CH or N; X' is CH or N; and Y is CH or N; or a pharmaceutically acceptable salt thereof. R is C 1-6 alkyl or n is 0 or 1 R 1 is absent, halo, cyano, C 1-6 alkyl, or -C(=O)N(CH 3) 2; R 2 is absent, halo, cyano, -C(=O)NH 2, or -C(=O)N(CH 3) 2; R 3 is halo or -C(=O)R 3a, R 3a is R 3a' or R 3a"; R 3a' is heterocycloalkyl, optionally substituted with C 1-6 alkyl, amino, C 1-10 alkyl amino, di C 1-10 alkyl amino, or N(CH 3)C(=O)OC(CH 3) 3; R 3a" is -OR 3b, NH(CH 2) 2 R 3c; NHCN, NHS(=O) 2 R 3d, or NHR 3e; R 3b is H or C 1-6 alkyl; R 3c is C 1-6 alkoxy, amino, C 1-10 alkyl amino or di C 1-10 alkyl amino; R 3d is C 1-6 alkyl or cycloalkyl; R 3e is heterocycloalkyl, C 1-6 alkyl heterocycloalkyl, or (CH 2) 2 N(CH 3)C(=O)OC(CH 3) 3; R 4 is absent, C 1-6 alkyl, C 1-6 alkoxy, cyano, hydroxy, or halo; R 5 is halo or C 1-6 alkyl; R 6 is absent, halo, C 1-6 alkyl, or C 1-6 alkoxy; R 7 is H or R 7 and R 4 come together to form -C(=O)-; R 8 is absent, C 1-6 alkyl, hydroxy, or halo; R 9 is absent or halo; X is CH or N; X' is CH or N; and Y is CH or N;
A high strength nonwoven wipe material comprising: from about 45 to about 95 weight percent matrix fibers selected from the group consisting of cellulosic fibers, synthetic fibers, and a mixture of cellulosic fibers and synthetic fibers; from about 5 to about 55 weight percent bicomponent fiber, wherein the bicomponent fiber has a length of from about 3 mm to about 36 mm; and optionally, from about 0 to about 15 weight percent binder, wherein the weight percentages are based on the total weight of the material, and wherein the material has a basis weight of from about 50 g/m 2 to about 75 g/m 2; a density of from about 0.03 to about 0.15 g/cm 3; and a CDW tensile strength of about 147 g/cm or greater. from about 45 to about 95 weight percent matrix fibers selected from the group consisting of cellulosic fibers, synthetic fibers, and a mixture of cellulosic fibers and synthetic fibers; from about 5 to about 55 weight percent bicomponent fiber, wherein the bicomponent fiber has a length of from about 3 mm to about 36 mm; and optionally, from about 0 to about 15 weight percent binder, wherein the weight percentages are based on the total weight of the material, and wherein the material has a basis weight of from about 50 g/m 2 to about 75 g/m 2; a density of from about 0.03 to about 0.15 g/cm 3; and a CDW tensile strength of about 147 g/cm or greater.
An electric motor comprising a rotor assembly of generally cylindrical symmetry about a rotation axis thereof, and a stator assembly arranged outside the rotor assembly, the stator assembly also being generally cylindrically symmetric about the rotation axis, thereby defining radial and circumferential directions as viewed in cross-section perpendicular to the rotation axis; the stator assembly having a plurality of stator pole pieces extending radially inwardly to form stator teeth; the rotor assembly having an outer radius referred to as the rotor radius (r) and the stator assembly having an inner radius referred to as the stator radius which is larger than the rotor radius (r) by an amount which results in a coupling gap between the rotor assembly and the stator assembly dimensioned to provide effective electromagnetic coupling therebetween, the rotor assembly having a plurality of rotor pole pieces extending radially outwardly from a rotor hub to form rotor teeth having first and second radially extending side surfaces connected by a top surface, the rotor assembly further including non-magnetic pieces fitted between the rotor teeth to reduce windage losses, each non-magnetic piece having first and second ends respectively connected to first and second mutually facing side surfaces of circumferentially adjacent rotor teeth by first and second lugs which engage in slots formed in the side surfaces of the rotor teeth part way up the rotor teeth between the base surface and the top surface, wherein the non-magnetic pieces are formed as bridge pieces spanning between adjacent rotor teeth and suspended above the rotor hub, wherein the lugs extend in a direction having components extending both circumferentially and radially inwardly, and wherein radially outwardly of each lug the bridge piece has a side surface arranged in abutment with a portion of the side surface of the adjacent tooth, wherein connecting the upper surface of each lug with the side surface of each bridge piece, the bridge piece has a curved surface portion with a direction of curvature opposite to that of the upper surface of the lug to connect with the adjacent side surface of the bridge piece so that there is a radial separation between each lug and its adjacent side surface, and a hollow region of approximately semi-circular cross-section is formed bounded by the bridge piece curved surface portion and a portion of the tooth side surface.
An object information acquiring apparatus, comprising: an adaptive beamformer (9, 10, 11, 12, 13) configured to perform adaptive beamforming of adjusting reception directionality based on a constraint vector in accordance with a reception signal in use of the reception signal, wherein the reception signal is an electric signal converted from a received acoustic wave; a delay-and-sum beamformer configured to perform delay-and-sum beamforming having preset directionality in use of the reception signal; a calculation circuit (21, 22, 23) configured to calculate a modulation ratio, an amplitude modulator configured to use an output signal of one of the adaptive beamformer and the delay-and-sum beamformer, to perform amplitude modulation on an output signal of the other one of the beamformers by using the modulation ratio; and a generator configured to, on the basis of a signal outputted by the amplitude modulator, generate image data on the interior of the object, characterized in that the calculation circuit (21, 22, 23) is configured to calculate the modulation ratio as an attenuation ratio of an output from the delay-and-sum beamformer on the basis of an output signal from the adaptive beamformer and signal intensity worked out using the constraint vector. a delay-and-sum beamformer configured to perform delay-and-sum beamforming having preset directionality in use of the reception signal; a calculation circuit (21, 22, 23) configured to calculate a modulation ratio, an amplitude modulator configured to use an output signal of one of the adaptive beamformer and the delay-and-sum beamformer, to perform amplitude modulation on an output signal of the other one of the beamformers by using the modulation ratio; and a generator configured to, on the basis of a signal outputted by the amplitude modulator, generate image data on the interior of the object, characterized in that the calculation circuit (21, 22, 23) is configured to calculate the modulation ratio as an attenuation ratio of an output from the delay-and-sum beamformer on the basis of an output signal from the adaptive beamformer and signal intensity worked out using the constraint vector.
Refrigeration device, especially a household refrigeration device, with a housing and a door delimiting a thermally-insulated interior space and at least one refrigerated goods carrier able to be mounted in the interior space, wherein opposing recesses are disposed in each case in two opposite inside walls which each accept similar removable modules having first, front supports (7b, 10b, 12b) adjacent to the door and second, rear supports (7a, 10a, 12a) facing away from the door for supporting the refrigerated goods carrier, characterised in that the first and second supports of the removable module are friction bearings which project beyond the surface of the module towards the interior space for horizontally-displaceable support of the refrigerated goods carrier and each module has an upper friction bearing and a lower friction bearing and the refrigerated goods carrier embodied as a shelf is inserted into a friction bearing.
A self-retaining suture system, the system comprising a self-retaining suture (100, 200, 300, 400, 500, 520, 540, 560, 600, 620, 640, 700, 800, 900) and a needle having a diameter, the self-retaining suture comprising: a first end for penetrating tissue (101, 201, 301, 401), wherein the first end is attached to the needle; an elongated suture body (102, 202, 302, 402, 602, 702, 802, 902) having a periphery; a first plurality of retainers (204, 544, 564) on the periphery of the elongated body and oriented towards the first end, the first plurality of retainers yielding toward the suture body during movement of the suture through tissue in a direction of deployment of the first end, and resisting movement of the suture, when in tissue, in a direction opposite the direction of deployment of the first end; and a second end having a variable loop (108, 208, 408, 508, 528, 548, 568, 608, 628, 648, 708, 808, 908) of variable circumference, wherein a fixed loop (112, 212, 412, 512, 532, 552, 572, 612, 632, 652, 712, 812, 912) at an end of the elongated suture body slidably engages the elongated body for slidingly varying the circumference of the variable loop, the fixed loop having a diameter; wherein the first end may pass through the variable loop to secure tissue as an anchor, the anchor preventing movement of the suture in the direction of deployment of the first end; characterized by the diameter of the needle being greater than the diameter of the fixed loop. a first end for penetrating tissue (101, 201, 301, 401), wherein the first end is attached to the needle; an elongated suture body (102, 202, 302, 402, 602, 702, 802, 902) having a periphery; a first plurality of retainers (204, 544, 564) on the periphery of the elongated body and oriented towards the first end, the first plurality of retainers yielding toward the suture body during movement of the suture through tissue in a direction of deployment of the first end, and resisting movement of the suture, when in tissue, in a direction opposite the direction of deployment of the first end; and a second end having a variable loop (108, 208, 408, 508, 528, 548, 568, 608, 628, 648, 708, 808, 908) of variable circumference, wherein a fixed loop (112, 212, 412, 512, 532, 552, 572, 612, 632, 652, 712, 812, 912) at an end of the elongated suture body slidably engages the elongated body for slidingly varying the circumference of the variable loop, the fixed loop having a diameter; wherein the first end may pass through the variable loop to secure tissue as an anchor, the anchor preventing movement of the suture in the direction of deployment of the first end; characterized by the diameter of the needle being greater than the diameter of the fixed loop.
A cassette device arranged to be removably mounted in or to a printing device of a weighing scale, the cassette device comprising a feed-hub and a take-up hub, the feed hub comprises a signal generating means suitable for cooperation with a hub sensor to produce a signal upon rotation of the feed hub, the cassette device being characterised in that the feed hub comprises a removable outer feed hub sleeve and an inner feed hub core to accommodate rolls of paper having different radii or diameters, and the signal generating means comprises a first marker on the removable outer feed-hub sleeve and a second marker on the inner core of the feed-hub, such that upon rotation of the feed hub, the combination of the first maker and the second marker cooperates with the hub sensor to produce a pattern of pulses indicative of the presence of both the inner core of the feed hub and the outer feed hub sleeve that is different from the pattern of pulses produced upon rotation of the inner core of the feed hub alone.
An end effector assembly of a tissue-resecting device, the end effector assembly comprising: an outer shaft defining a proximal end portion and a distal end portion, the distal end portion of the outer shaft defining a window therethrough; a drive wire extending through the outer shaft and including a cylindrical body and a distal end portion defining a semi-cylindrical configuration including a semi-cylindrical bottom surface and a planar top surface; and a distal cutting tip disposed within the outer shaft and at least partially overlapping the window, the distal cutting tip defining a semi-cylindrical lumen defined by a semi-cylindrical bottom surface and an open top, wherein the distal end portion of the drive wire is at least partially received within the semi-cylindrical lumen of the distal cutting tip and engaged therein with the semi-cylindrical bottom surface of the distal end portion of the drive wire substantially mating with the semi-cylindrical bottom surface of the distal cutting tip, the drive wire configured to drive rotation or oscillation of the distal cutting tip relative to the outer shaft, wherein the distal cutting tip includes a plurality of teeth extending along a portion of a length thereof, the plurality of teeth including a first set of teeth disposed on a first side of the semi-cylindrical lumen and a second set of teeth disposed on a second, opposite side of the semi-cylindrical lumen, and wherein a distal end of the distal end portion of the drive wire does not extend distally beyond a first tooth of each of the first and second sets of teeth. an outer shaft defining a proximal end portion and a distal end portion, the distal end portion of the outer shaft defining a window therethrough; a drive wire extending through the outer shaft and including a cylindrical body and a distal end portion defining a semi-cylindrical configuration including a semi-cylindrical bottom surface and a planar top surface; and a distal cutting tip disposed within the outer shaft and at least partially overlapping the window, the distal cutting tip defining a semi-cylindrical lumen defined by a semi-cylindrical bottom surface and an open top, wherein the distal end portion of the drive wire is at least partially received within the semi-cylindrical lumen of the distal cutting tip and engaged therein with the semi-cylindrical bottom surface of the distal end portion of the drive wire substantially mating with the semi-cylindrical bottom surface of the distal cutting tip, the drive wire configured to drive rotation or oscillation of the distal cutting tip relative to the outer shaft, wherein the distal cutting tip includes a plurality of teeth extending along a portion of a length thereof, the plurality of teeth including a first set of teeth disposed on a first side of the semi-cylindrical lumen and a second set of teeth disposed on a second, opposite side of the semi-cylindrical lumen, and wherein a distal end of the distal end portion of the drive wire does not extend distally beyond a first tooth of each of the first and second sets of teeth.
Apparatus for aligning guide rails in an elevator shaft, a lifting machinery moving an elevator car in a first direction upwards and downwards in the vertically extending elevator shaft being restricted by wall structures, the elevator car being guided by guide rails supported on the wall structures in the elevator shaft, the apparatus comprising: a positioning unit extending horizontally across the elevator shaft in a second direction and comprising first attachment means (140, 150) movable in the second direction at each end of the positioning unit for supporting the positioning unit on the opposite wall structures or other support structures in the elevator shaft, an alignment unit extending across the elevator shaft in the second direction and being supported with support parts (260, 270) on each end portion of the positioning unit so that each end portion of the alignment unit is individually movable in relation to the positioning unit in a third direction perpendicular to the second direction, and comprising second attachment means (240, 250) movable in the second direction at each end of the alignment unit for supporting the alignment unit on opposite guide rails in the shaft, said second attachment means (240, 250) comprising gripping means (245, 255) for gripping on the guide rail, whereby opposite guide rails can be adjusted in relation to each other and in relation to the elevator shaft with the apparatus, characterised in that: the positioning unit and the alignment unit comprises a centre portion (110, 210) and two opposite end portions (120, 130, 220, 230), whereby the centre portion (110, 210) is changeable in order to change the length of the positioning unit and the alignment unit and thereby adapt the apparatus to elevator shafts of different dimensions. a positioning unit extending horizontally across the elevator shaft in a second direction and comprising first attachment means (140, 150) movable in the second direction at each end of the positioning unit for supporting the positioning unit on the opposite wall structures or other support structures in the elevator shaft, an alignment unit extending across the elevator shaft in the second direction and being supported with support parts (260, 270) on each end portion of the positioning unit so that each end portion of the alignment unit is individually movable in relation to the positioning unit in a third direction perpendicular to the second direction, and comprising second attachment means (240, 250) movable in the second direction at each end of the alignment unit for supporting the alignment unit on opposite guide rails in the shaft, said second attachment means (240, 250) comprising gripping means (245, 255) for gripping on the guide rail, whereby the positioning unit and the alignment unit comprises a centre portion (110, 210) and two opposite end portions (120, 130, 220, 230), whereby the centre portion (110, 210) is changeable in order to change the length of the positioning unit and the alignment unit and thereby adapt the apparatus to elevator shafts of different dimensions.
An antisense oligonucleotide for use in treating, inhibiting, and/or preventing cholestasis in a subject, wherein said antisense oligonucleotide specifically hybridizes with miR-27a or miR-182.
A card-shaped data carrier having optical features for improved perception, comprising: a first and a second cover layer, wherein between the first and the second cover layer there is disposed at least one translucent inner layer which forms at least a part of a card edge, characterized in that the at least one translucent inner layer is bevelled a first and a second cover layer, wherein between the first and the second cover layer there is disposed at least one translucent inner layer which forms at least a part of a card edge, characterized in that the at least one translucent inner layer is bevelled
A trackball comprising a body that is intended to be fixed to a workstation, a sphere that is rotatable with respect to the body, a set of sensors (16, 17) that provide information relating to the relative position of the sphere with respect to the body, and means for braking the rotational movements of the sphere with respect to the body, characterised in that the braking means comprise a friction ring that encircles the sphere, in that the ring extends mainly in one plane, and in that the ring is free to move translationally in the plane in which the ring extends.
A system for detecting gluten in a food sample, comprising a single-use cartridge, comprising a sensor comprising a graphene layer disposed on an underlying substrate, a plurality of antibodies coupled to said graphene layer, said antibodies being configured for selective binding to a gluten protein, a plurality of metallic leads coupled to said anti-body functionalized graphene layer for detecting a change in electrical resistance thereof in response to interaction with said gluten protein, said cartridge further comprising a microfluidic sample delivery component comprising an inlet port for receiving the sample and one or more microfluidic channels for delivering at least a portion of the sample to said sensor, and said system further comprising an analyzer separate from said cartridge and configured for electrical coupling to said sensor, wherein said analyzer comprises: a data acquisition unit having a current source for applying a known current to said anti-body functionalized graphene layer, and a voltage meter for detecting a change in a voltage across said anti-body functionalized graphene layer, if any, in response to exposure of said anti-body functionalized graphene layer to a sample suspected of containing gluten, and an analysis module in communication with said data acquisition unit to compute a change in electrical resistance of said anti-body functionalized graphene layer based on said known current value and said detected change in voltage and determine whether gluten is present in the sample based on said change in the electrical resistance. a sensor comprising a graphene layer disposed on an underlying substrate, a plurality of antibodies coupled to said graphene layer, said antibodies being configured for selective binding to a gluten protein, a plurality of metallic leads coupled to said anti-body functionalized graphene layer for detecting a change in electrical resistance thereof in response to interaction with said gluten protein, said cartridge further comprising a microfluidic sample delivery component comprising an inlet port for receiving the sample and one or more microfluidic channels for delivering at least a portion of the sample to said sensor, and a data acquisition unit having a current source for applying a known current to said anti-body functionalized graphene layer, and a voltage meter for detecting a change in a voltage across said anti-body functionalized graphene layer, if any, in response to exposure of said anti-body functionalized graphene layer to a sample suspected of containing gluten, and an analysis module in communication with said data acquisition unit to compute a change in electrical resistance of said anti-body functionalized graphene layer based on said known current value and said detected change in voltage and determine whether gluten is present in the sample based on said change in the electrical resistance.
A tray for accommodating a cell culture for use during culturing thereof and/or for optical monitoring of the cell culture, the tray comprising a carrier structure defining at least one accommodating zone for accommodating the cell culture; characterised in that the carrier structure comprises at least one focal lens, which is integrally formed with or bonded to the carrier structure, the at least one focal lens being arranged to collect light rays emanating from the at least one accommodating zone so as to facilitate monitoring of the cell culture through the focal lens and the carrier structure, wherein a diameter of the focal lens exceeds a diameter of the at least one accommodating zone.