System for trans-dermal delivery of doses of a medicament, comprising a) a delivery device to be placed in dermal contact with a patient, the delivery device comprising - a reservoir for holding a medicament to be delivered, - a trans-dermal injection element for delivering doses of the medicament to the patient, - a control unit to control the way an energy external to the delivery device is transformed into pumping force and to guarantee that the correct dose of medicament is pumped and only when a dose is requested, the control unit comprising - one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into pumping force, and - at least one safe-lock mechanism preventing anyone or more of the rotors to rotate and/or axial pump elements to move or otherwise preventing the passage of medicament from the reservoir to the trans-dermal injection device until a dose is to be delivered, b) a separate hand-held drive device to be temporarily placed in proximity of the delivery device only when a dose of medicament is required and to be kept separate from the delivery device when a dose of medicament is not required, the drive device comprising an activation unit for providing the correct amount and form of energy to the control unit of the delivery device, the activation unit comprising at least one unlocking element to provide the energy required for unlocking the at least one safe-lock mechanism and a drive unit to provide the energy required for anyone or more of the rotors and/or axial pump elements of the control unit to rotate and/or to move and to be transformed into pumping force. a) a delivery device to be placed in dermal contact with a patient, the delivery device comprising - a reservoir for holding a medicament to be delivered, - a trans-dermal injection element for delivering doses of the medicament to the patient, - a control unit to control the way an energy external to the delivery device is transformed into pumping force and to guarantee that the correct dose of medicament is pumped and only when a dose is requested, the control unit comprising - one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into pumping force, and - at least one safe-lock mechanism preventing anyone or more of the rotors to rotate and/or axial pump elements to move or otherwise preventing the passage of medicament from the reservoir to the trans-dermal injection device until a dose is to be delivered, - a reservoir for holding a medicament to be delivered, - a trans-dermal injection element for delivering doses of the medicament to the patient, - a control unit to control the way an energy external to the delivery device is transformed into pumping force and to guarantee that the correct dose of medicament is pumped and only when a dose is requested, the control unit comprising - one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into pumping force, and - at least one safe-lock mechanism preventing anyone or more of the rotors to rotate and/or axial pump elements to move or otherwise preventing the passage of medicament from the reservoir to the trans-dermal injection device until a dose is to be delivered, - one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into pumping force, and - at least one safe-lock mechanism preventing anyone or more of the rotors to rotate and/or axial pump elements to move or otherwise preventing the passage of medicament from the reservoir to the trans-dermal injection device until a dose is to be delivered, b) a separate hand-held drive device to be temporarily placed in proximity of the delivery device only when a dose of medicament is required and to be kept separate from the delivery device when a dose of medicament is not required, the drive device comprising an activation unit for providing the correct amount and form of energy to the control unit of the delivery device, the activation unit comprising at least one unlocking element to provide the energy required for unlocking the at least one safe-lock mechanism and a drive unit to provide the energy required for anyone or more of the rotors and/or axial pump elements of the control unit to rotate and/or to move and to be transformed into pumping force.