A system to acquire image data of a patient with an imaging system using enhanced contrast imaging, comprising: an imaging system having a first energy source with one or more first energy parameters and a second energy source with one or more second energy parameters; a pump operable to inject a contrast agent into the patient in response to an instruction; a timer operable to determine an amount of time that has passed since the beginning of the injection of the contrast agent by the pump; a controller in communication with the imaging system and the pump, wherein the controller times the image data acquisition based on the amount of time passed as timed by the timer; an image data indexer, wherein the image data is collected of the patient over time and time stamped by the timer and the image data indexer is operable to execute instructions to determine whether a selected portion of the image data is regarding a first anatomical phase or a second anatomical phase based on the indexed time of the image data; wherein the imaging system is operable to communicate with the pump through the controller regarding timing of the injection of the contrast agent into the patient and is further operable to acquire image data based upon the timing of the injection of the contrast agent and a path of the first energy source and the second energy source; characterised in that the imaging system is adapted to: (i) determine in one or more regions of interest in at least one image frame acquired with said imaging system, and (ii) selectively include image frames, of the first anatomical phase or the second anatomical phase having a high intensity in said determined one or more regions of interest relating to a presence of the contrast agent, in a volumetric or three-dimensional model reconstructed from said selectively included image frames. an imaging system having a first energy source with one or more first energy parameters and a second energy source with one or more second energy parameters; a pump operable to inject a contrast agent into the patient in response to an instruction; a timer operable to determine an amount of time that has passed since the beginning of the injection of the contrast agent by the pump; a controller in communication with the imaging system and the pump, wherein the controller times the image data acquisition based on the amount of time passed as timed by the timer; an image data indexer, wherein the image data is collected of the patient over time and time stamped by the timer and the image data indexer is operable to execute instructions to determine whether a selected portion of the image data is regarding a first anatomical phase or a second anatomical phase based on the indexed time of the image data; wherein the imaging system is operable to communicate with the pump through the controller regarding timing of the injection of the contrast agent into the patient and is further operable to acquire image data based upon the timing of the injection of the contrast agent and a path of the first energy source and the second energy source; characterised in that the imaging system is adapted to: (i) determine in one or more regions of interest in at least one image frame acquired with said imaging system, and (ii) selectively include image frames, of the first anatomical phase or the second anatomical phase having a high intensity in said determined one or more regions of interest relating to a presence of the contrast agent, in a volumetric or three-dimensional model reconstructed from said selectively included image frames. (i) determine in one or more regions of interest in at least one image frame acquired with said imaging system, and (ii) selectively include image frames, of the first anatomical phase or the second anatomical phase having a high intensity in said determined one or more regions of interest relating to a presence of the contrast agent, in a volumetric or three-dimensional model reconstructed from said selectively included image frames.