A method for determining a glucose concentration with a system having a test strip and a meter having a test circuit including a microprocessor, the method comprising: initiating a chemical reaction between a reference electrode and a second working electrode coated with a reagent layer and between the reference electrode and a first working electrode coated with a reagent layer of the test strip; sampling a plurality of test currents, wherein the sampling comprises: measuring a primary test current on one of the first and second working electrodes; measuring a secondary test current on the one of the first and second working electrodes; wherein the method further comprises using the primary and secondary currents to determine whether there is a positive rate of change in current after initiation of the chemical reaction between about 0 and about 1 second, wherein it is determined that there is a positive rate of change if a difference between the primary test current and secondary test current is less than zero; and upon determining that the difference is less than zero, deriving a glucose concentration based on the plurality of test currents else otherwise returning an error. initiating a chemical reaction between a reference electrode and a second working electrode coated with a reagent layer and between the reference electrode and a first working electrode coated with a reagent layer of the test strip; sampling a plurality of test currents, wherein the sampling comprises: measuring a primary test current on one of the first and second working electrodes; measuring a secondary test current on the one of the first and second working electrodes; wherein the method further comprises using the primary and secondary currents to determine whether there is a positive rate of change in current after initiation of the chemical reaction between about 0 and about 1 second, wherein it is determined that there is a positive rate of change if a difference between the primary test current and secondary test current is less than zero; and upon determining that the difference is less than zero, deriving a glucose concentration based on the plurality of test currents else otherwise returning an error. measuring a primary test current on one of the first and second working electrodes; measuring a secondary test current on the one of the first and second working electrodes; wherein the method further comprises using the primary and secondary currents to determine whether there is a positive rate of change in current after initiation of the chemical reaction between about 0 and about 1 second, wherein it is determined that there is a positive rate of change if a difference between the primary test current and secondary test current is less than zero; and upon determining that the difference is less than zero, deriving a glucose concentration based on the plurality of test currents else otherwise returning an error. using the primary and secondary currents to determine whether there is a positive rate of change in current after initiation of the chemical reaction between about 0 and about 1 second, wherein it is determined that there is a positive rate of change if a difference between the primary test current and secondary test current is less than zero; and upon determining that the difference is less than zero, deriving a glucose concentration based on the plurality of test currents else otherwise returning an error.