A method of using a system (1, 1101) to produce dynamic conditions which would be experienced by in vivo tubular structures in a patient with a particular patient history when undergoing a physiological experience, comprising: inputting physical characteristics of an in vivo tubular structure located in the patient and inputting patient history information; selecting a non in vivo tubular structure corresponding to the in vivo structure or providing an in vivo tubular structure that has been removed from the patient; inserting the selected tubular structure into the system (1, 1101), wherein the system (1, 1101) comprises: a specimen holder for holding the tubular structure, a mounting system for positioning the tubular structure in the specimen holder, a steady flow system initiating a flow of fluid introduced into a flow loop, wherein the flow of fluid passes into the specimen holder, a pressure/flow control system that generates and maintains dynamic fluid pressure and flow conditions within the specimen holder, wherein fluid pressure and flow rate can be independently controlled, and a control system (70, 1103) for sending control signals to the steady flow system and to the pressure/flow control system, wherein the control system provides for dynamic control of the system based on feedback provided by a variety of sensing/detection systems; selecting a physiological experience; and implementing the selected physiological experience using the system. inputting physical characteristics of an in vivo tubular structure located in the patient and inputting patient history information; selecting a non in vivo tubular structure corresponding to the in vivo structure or providing an in vivo tubular structure that has been removed from the patient; inserting the selected tubular structure into the system (1, 1101), wherein the system (1, 1101) comprises: a specimen holder for holding the tubular structure, a mounting system for positioning the tubular structure in the specimen holder, a steady flow system initiating a flow of fluid introduced into a flow loop, wherein the flow of fluid passes into the specimen holder, a pressure/flow control system that generates and maintains dynamic fluid pressure and flow conditions within the specimen holder, wherein fluid pressure and flow rate can be independently controlled, and a control system (70, 1103) for sending control signals to the steady flow system and to the pressure/flow control system, wherein the control system provides for dynamic control of the system based on feedback provided by a variety of sensing/detection systems; a specimen holder for holding the tubular structure, a mounting system for positioning the tubular structure in the specimen holder, a steady flow system initiating a flow of fluid introduced into a flow loop, wherein the flow of fluid passes into the specimen holder, a pressure/flow control system that generates and maintains dynamic fluid pressure and flow conditions within the specimen holder, wherein fluid pressure and flow rate can be independently controlled, and a control system (70, 1103) for sending control signals to the steady flow system and to the pressure/flow control system, wherein the control system provides for dynamic control of the system based on feedback provided by a variety of sensing/detection systems; selecting a physiological experience; and implementing the selected physiological experience using the system.