mhurhangee/ep-ind-claims huggingface dataset:
A cyclodextrin-containing polymer -topoisomerase inhibitor conjugate for use in a method of treating a cancer in a subject, wherein the method comprises: providing an initial administration of said CDP-topoisomerase inhibitor conjugate to said subject at a dosage of 12 mg/m 2, 13 mg/m 2, 14 mg/m 2 or 15 mg/m 2, wherein said dosage is expressed in mg of topoisomerase inhibitor, as opposed to mg of conjugate; and providing more than one subsequent administration of said CDP-topoisomerase inhibitor conjugate at a dosage of 12 mg/m 2, 13 mg/m 2, 14 mg/m 2 or 15 mg/m 2, wherein each subsequent administration is provided, independently, between 12, 13, 14, 15 or 16 days after the previous administration; wherein the method comprises administering said CDP-topoisomerase inhibitor conjugate in combination with one or more additional therapeutic agents; wherein the CDP-topoisomerase inhibitor conjugate is a CDP-camptothecin conjugate; and wherein the CDP-camptothecin conjugate is CRLX101. providing an initial administration of said CDP-topoisomerase inhibitor conjugate to said subject at a dosage of 12 mg/m 2, 13 mg/m 2, 14 mg/m 2 or 15 mg/m 2, wherein said dosage is expressed in mg of topoisomerase inhibitor, as opposed to mg of conjugate; and providing more than one subsequent administration of said CDP-topoisomerase inhibitor conjugate at a dosage of 12 mg/m 2, 13 mg/m 2, 14 mg/m 2 or 15 mg/m 2, wherein each subsequent administration is provided, independently, between 12, 13, 14, 15 or 16 days after the previous administration; wherein the method comprises administering said CDP-topoisomerase inhibitor conjugate in combination with one or more additional therapeutic agents; wherein the CDP-topoisomerase inhibitor conjugate is a CDP-camptothecin conjugate; and wherein the CDP-camptothecin conjugate is CRLX101.
A light emitting device (B, G, H) comprising: a laser light source that emits laser light; a housing that includes a bottom wall (3, 3A) and a side wall; and a first wavelength converter provided on the side wall, the first wavelength converter containing a first phosphor, wherein the bottom wall (3, 3A) of the housing is irradiated with the laser light emitted from the laser light source, the first phosphor is excited by diffused light of the laser light diffused by the bottom wall (3, 3A), the bottom wall (3, 3A) of the housing, is directly irradiated with the laser light while the first wavelength converter is not directly irradiated with the laser light, the bottom wall of the housing is made of a translucent member that transmits the laser light, and the laser light enters an internal space of the housing through the bottom wall. a laser light source that emits laser light; a housing that includes a bottom wall (3, 3A) and a side wall; and a first wavelength converter provided on the side wall, the first wavelength converter containing a first phosphor, wherein the bottom wall (3, 3A) of the housing is irradiated with the laser light emitted from the laser light source, the first phosphor is excited by diffused light of the laser light diffused by the bottom wall (3, 3A), the bottom wall (3, 3A) of the housing, is directly irradiated with the laser light while the first wavelength converter is not directly irradiated with the laser light, the bottom wall of the housing is made of a translucent member that transmits the laser light, and the laser light enters an internal space of the housing through the bottom wall.
Device for delivering fuel, with a storage tank, a delivery unit sucking up fuel from the storage tank, a line which is mounted rotatably about an axis of rotation and has an impressed curved or angled shape, and with a stop limiting the rotatability of the line, and wherein the line is a suction line which is connected to a negative pressure source via a connection provided on the storage tank, characterized in that a plug is provided at that end of the suction line which faces the connection, said plug being connectable to the connection and having a connecting duct which opens into the storage tank and is connected in terms of flow to the suction line, and in that the stop is arranged on the storage tank in such a manner that, when the storage tank is placed onto a base, the suction line is prestressed against the base.
A bicycle comprising: a frame including a head tube which rotatably receives a front fork assembly comprising a pair of tubular fork legs connected to a fork crown at one end thereof, and a steerer tube extending axially away from the fork crown and rotationally received in the head tube; and a steering assembly including a stem; characterized in that the bicycle further comprises a suspension assembly received within an inner diameter of the steerer tube such that it projects above an upper end of the steerer tube, the suspension assembly including a lower tubular support and an upper tubular support longitudinally slidable relative to the lower support, the lower and upper supports (104, 102) receiving a first positive biasing means and a first negative biasing means; wherein the stem is connected to the upper support; and wherein the lower and upper supports (104, 102) are respectively connected to the steerer tube and stem such that the upper support slides longitudinally relative to the lower support adjacent the stem and above the fork crown. a frame including a head tube which rotatably receives a front fork assembly comprising a pair of tubular fork legs connected to a fork crown at one end thereof, and a steerer tube extending axially away from the fork crown and rotationally received in the head tube; and a steering assembly including a stem; characterized in that the bicycle further comprises a suspension assembly received within an inner diameter of the steerer tube such that it projects above an upper end of the steerer tube, the suspension assembly including a lower tubular support and an upper tubular support longitudinally slidable relative to the lower support, the lower and upper supports (104, 102) receiving a first positive biasing means and a first negative biasing means; wherein the stem is connected to the upper support; and wherein the lower and upper supports (104, 102) are respectively connected to the steerer tube and stem such that the upper support slides longitudinally relative to the lower support adjacent the stem and above the fork crown.
A kit comprising: a stand mixer comprising; a head unit having a lower surface presenting, in operation, a downwardly-facing drive outlet for driving in rotation at least one tool suspended therefrom, support means for supporting said head unit with said downwardly-facing drive outlet above a receiving location for a mixing bowl, and driving means including an electric motor and associated transmission means for conveying rotary drive to said drive outlet, first and second coaxial driving outlets (80, 90) presented on an upper surface of said head unit, said coaxial outlets running at different speeds and being driven from said motor by means of an epicyclic gearbox; a first attachment for coupling to the first drive outlet of the stand mixer; a second attachment for coupling to the second drive outlet of the stand mixer; and a tool for coupling to the downwardly-facing drive outlet of the stand mixer. a stand mixer comprising; a head unit having a lower surface presenting, in operation, a downwardly-facing drive outlet for driving in rotation at least one tool suspended therefrom, support means for supporting said head unit with said downwardly-facing drive outlet above a receiving location for a mixing bowl, and driving means including an electric motor and associated transmission means for conveying rotary drive to said drive outlet, first and second coaxial driving outlets (80, 90) presented on an upper surface of said head unit, said coaxial outlets running at different speeds and being driven from said motor by means of an epicyclic gearbox; a first attachment for coupling to the first drive outlet of the stand mixer; a second attachment for coupling to the second drive outlet of the stand mixer; and a tool for coupling to the downwardly-facing drive outlet of the stand mixer.
A method performed by an apparatus of controlling a wireless transmission of a network element (62; 72) of a radio access network where signal propagation is unknown, wherein the network element is configured to inhibit use of a licensed shared access spectrum, the method comprising: determining interference levels introduced by the network element when using the licensed shared access spectrum, checking whether or not the interference levels violate agreed interference levels in predefined reservation zones of the licensed shared access spectrum; configuring the network element to allow use of the licensed shared access spectrum in case the interference levels do not violate the agreed interference levels in the predefined reservation zones; characterized by comprising: in case the interference levels violate the agreed interference levels and the network element is configured to inhibit use of the licensed shared access spectrum, enabling use of the licensed shared access spectrum upon receiving an offer command for the predefined reservation zones; and in case the interference levels violate the agreed interference levels and the network element is configured to allow use of the licensed shared access spectrum, disabling use of the licensed shared access spectrum upon receiving an evacuation command for the predefined reservation zones. determining interference levels introduced by the network element when using the licensed shared access spectrum, checking whether or not the interference levels violate agreed interference levels in predefined reservation zones of the licensed shared access spectrum; configuring the network element to allow use of the licensed shared access spectrum in case the interference levels do not violate the agreed interference levels in the predefined reservation zones; characterized by comprising: in case the interference levels violate the agreed interference levels and the network element is configured to inhibit use of the licensed shared access spectrum, enabling use of the licensed shared access spectrum upon receiving an offer command for the predefined reservation zones; and in case the interference levels violate the agreed interference levels and the network element is configured to allow use of the licensed shared access spectrum, disabling use of the licensed shared access spectrum upon receiving an evacuation command for the predefined reservation zones. in case the interference levels violate the agreed interference levels and the network element is configured to inhibit use of the licensed shared access spectrum, enabling use of the licensed shared access spectrum upon receiving an offer command for the predefined reservation zones; and in case the interference levels violate the agreed interference levels and the network element is configured to allow use of the licensed shared access spectrum, disabling use of the licensed shared access spectrum upon receiving an evacuation command for the predefined reservation zones.
A reactor comprising ▪ a reaction vessel defining an inner volume, ▪ a compensation element, ▪ an inlet and an outlet (2a, 2b), ▪ a heating element, ▪ an insulation, characterized in that ▪ said inner volume is filled with a fixed bed; ▪ said fixed bed contains or consists of particles of formula, FeO x, where 0 ≤ x ≤ 1.5; and ▪ said fixed bed is free of cavities characterized in that they have a volume larger than 10000 mm 3 and that all principal radii are at least 3 mm long, said principal radii being the three principal radii of the biggest ellipsoid that fits into the cavity; ▪ said compensation element is adapted to adjust said inner volume. ▪ a reaction vessel defining an inner volume, ▪ a compensation element, ▪ an inlet and an outlet (2a, 2b), ▪ a heating element, ▪ an insulation, characterized in that ▪ said inner volume is filled with a fixed bed; ▪ said fixed bed contains or consists of particles of formula, FeO x, where 0 ≤ x ≤ 1.5; and ▪ said fixed bed is free of cavities characterized in that they have a volume larger than 10000 mm 3 and that all principal radii are at least 3 mm long, said principal radii being the three principal radii of the biggest ellipsoid that fits into the cavity; ▪ said compensation element is adapted to adjust said inner volume.
A tyre comprising: a tread portion; a bead portion; and a sidewall portion extending between the bead portion and the tread portion wherein the sidewall portion comprises two sidewalls; and wherein the tread portion, bead portion and sidewall portion define an inner cavity of the tyre; the tyre further comprising two noise reduction layers, one on each of the sidewalls, in the inner cavity of the tyre; characterised in that each noise reduction layer defines an inner radial side and an outer radial side and the inner radial side comprises at least one cutout, and in that the noise reduction layers define a thickness in a direction perpendicular to the sidewall portion and the thickness of the noise reduction layers varies in a radial direction of the tyre. a tread portion; a bead portion; and a sidewall portion extending between the bead portion and the tread portion wherein the sidewall portion comprises two sidewalls; and wherein the tread portion, bead portion and sidewall portion define an inner cavity of the tyre; the tyre further comprising two noise reduction layers, one on each of the sidewalls, in the inner cavity of the tyre; characterised in that each noise reduction layer defines an inner radial side and an outer radial side and the inner radial side comprises at least one cutout, and in that the noise reduction layers define a thickness in a direction perpendicular to the sidewall portion and the thickness of the noise reduction layers varies in a radial direction of the tyre.
A stem cell bank comprising a library or plurality of human parthenogenetic stem cell lines, each of which is homozygous for at least one MHC allele present in a human population, wherein each member of said plurality of stem cell lines is homozygous for a different set of MHC alleles relative to the remaining members of the plurality of stem cell lines.
A system for the underfloor arrangement of electrical and/or electronic devices, particularly for telecommunication, with a duct which is installable in the ground beneath the floor and which includes at least one cover, whereby arranged in the duct there is a cap, which covers the electrical and/or electronic devices, and with at least one fan, which is arranged to produce an air flow in the cap, characterised in that the cap is airtight, that arranged within the airtight cap there is a portion of a conduit system of a heat exchanger device, whose other portion is situated outside the cap in the duct and whose conduits are cooled by an air flow and that at least one further fan is arranged in the duct, by which the air is drawn in from the surroundings of the duct through an air inlet opening in the cover and directed towards the conduits of the heat exchanger device, whereby the heated air flows out through a further opening in the cover.
A coextruded multilayer film comprising: a core component comprising from 15 to 1000 alternating layers of layer A and layer B; layer A having a thickness from 100 nm to 500 nm and comprising a propylene-based polymer selected from the group consisting of (i) a propylene homopolymer with a crystallinity of from 30% to 55% and (ii) a propylene/a-olefin copolymer having a crystallinity from 10% to 40%, the propylene-based polymer having a crystallization temperature (T 1 c); layer B comprising a second polymer having a glass transition temperature (T 2 g), wherein T 1 c <T 2 g; and layer A has an effective moisture permeability from 1.55 g-25.4μm/m 2 /24 hr to less than or equal to 4.65 g-25.4μm/m 2 /24 hr, wherein the effective moisture permeability ( P B) is calculated in accordance with the following Equation: P B = V B 1 P − 1 − V B P c − 1 wherein P is the moisture permeability of the core component, V B is the volume fraction of the propylene-based polymer, V C is the volume fraction of the second polymer, P B is the moisture permeability of the propylene-based polymer, and P C is the moisture permeability of the second polymer, and moisture permeability is measured in accordance with ASTM F1249. a core component comprising from 15 to 1000 alternating layers of layer A and layer B; layer A having a thickness from 100 nm to 500 nm and comprising a propylene-based polymer selected from the group consisting of (i) a propylene homopolymer with a crystallinity of from 30% to 55% and (ii) a propylene/a-olefin copolymer having a crystallinity from 10% to 40%, the propylene-based polymer having a crystallization temperature (T 1 c); layer B comprising a second polymer having a glass transition temperature (T 2 g), wherein T 1 c <T 2 g; and layer A has an effective moisture permeability from 1.55 g-25.4μm/m 2 /24 hr to less than or equal to 4.65 g-25.4μm/m 2 /24 hr, wherein the effective moisture permeability ( P B) is calculated in accordance with the following Equation: P B = V B 1 P − 1 − V B P c − 1 wherein P is the moisture permeability of the core component, V B is the volume fraction of the propylene-based polymer, V C is the volume fraction of the second polymer, P B is the moisture permeability of the propylene-based polymer, and P C is the moisture permeability of the second polymer, and moisture permeability is measured in accordance with ASTM F1249.
Rotary control device comprising a user interface surface that is embodied to rotate with respect to a housing of the device around a rotational axis of the device, further comprising a sensor unit for monitoring the orientation and/or rotational movement of the user interface surface with respect to the housing, a processing unit, and a communications interface for transmitting control signals according to an output from the processing unit, said output being generated by the processing unit on the basis of sensor data from the sensor unit, wherein the rotary control device further comprises a magnetorheological actuator, wherein the magnetorheological actuator comprises a rotational element that is mechanically connected to the user interface surface and serves to interact with a magnetorheological fluid of the magnetorheological actuator, and wherein the magnetorheological actuator comprises an assembly for generating and/or manipulating properties of a magnetic field acting on the magnetorheological fluid such that the magnetorheological actuator serves to modulate torque transmission between the user interface surface and the housing, characterized in that in that the rotary control device further comprises a servo actuator that is embodied to apply torque to the user interface surface in accordance with governing signals output by the processing unit of the device.
A disposable support for containers for treating biological samples in cytocentrifuges, each one of said containers comprising a vertical flat supporting base from which a wall protrudes at right angles, said wall supporting at least one funnel (13, 14) that is connected in a lower region to a corresponding horizontal connection channel (15, 16), said support comprising, in a single element made of molded plastic material, a flat supporting body with longitudinal protruding edges and a protruding lower edge in order to accommodate in succession a slide, a filtering card and said base of said container for the treatment of biological samples, clamp means being further provided for retaining the slide, the filtering card and the container, said body integrating a transverse pivot for fixing the support to a cytocentrifuge, characterized in that it further comprises an elastic means for taking up any plays, said elastic means being integrated in said supporting body in the region where said slide rests, and in that said lower edge has at least one perpendicular containment tab, connection between said longitudinal edges and said body being provided by forming respective longitudinal channels, said clamp means being integrated with said longitudinal protruding edges and being constituted by two mutually opposite hook-shaped tabs, which are sized so as to retain between their ends and said body a slide, a filtering card and the base of said container, said tabs being extended, in the rear part of said body, by means of respective levers.
A process for producing a water-absorbent resin, which comprises the step of polymerizing an aqueous solution of water-absorbent resin-forming monomers including acrylic acid and/or its sodium salt as major components, wherein: the concentration of the water-absorbent resin-forming monomers is in the range of 35 to 60 weight %; the polymerization is carried out while water is evaporated so that the ratio of the solid component concentration by weight after polymerization in a hydropolymer as formed by the polymerization to the concentration by weight of the water-absorbent resin-forming monomers and other additives in the aqueous solution of the water-absorbent resin-forming monomers before the polymerization will not be less than 1.10; the highest temperature during the polymerization is not higher than 115 °C; and the hydropolymer as formed by the polymerization has a solid component concentration after polymerization of not more than 80 weight %; wherein the solid component concentration by weight after polymerization in the hydropolymer is measured by placing a sample of 5 g of the particulate hydropolymer or the hydropolymer as finely divided into a Petri dish and then drying it in a drying oven of 180 °C for 24 hours to calculate the solid component concentration in the hydropolymer. the concentration of the water-absorbent resin-forming monomers is in the range of 35 to 60 weight %; the polymerization is carried out while water is evaporated so that the ratio of the solid component concentration by weight after polymerization in a hydropolymer as formed by the polymerization to the concentration by weight of the water-absorbent resin-forming monomers and other additives in the aqueous solution of the water-absorbent resin-forming monomers before the polymerization will not be less than 1.10; the highest temperature during the polymerization is not higher than 115 °C; and the hydropolymer as formed by the polymerization has a solid component concentration after polymerization of not more than 80 weight %;
Timepiece arbor-ratchet assembly, including an arbor and a ratchet for winding a timepiece barrel, said ratchet including an axial passage for fitting the ratchet onto said arbor including protruding or recessed pivotal drive means, characterized in that said ratchet includes, in said axial passage, at least one strip spring permitting the fitting of said ratchet on said arbor and arranged to exert a bearing force on said pivotal drive means, wherein said at least one strip spring forms complementary drive means for pivotally driving said arbor.