mhurhangee/ep-ind-claims huggingface dataset:
A blocking ligand specific for CTLA-4 which is an anti-CTLA-4 antibody and a vascular targeting antibody/IL-2 complex, wherein the vascular targeting antibody is specific for alternatively spliced extradomain B of fibronectin, for sequential use in inhibiting the growth of tumour cells, wherein the anti-CTLA-4 antibody is administered before the vascular targeting antibody/IL-2 complex.
A process for reducing content of tar in a tar containing syngas, said process comprising: contacting said tar containing syngas with a molecular oxygen containing gas in a first reaction zone to produce a gas mixture; and passing said gas mixture through a heat treatment zone maintained at a temperature between 900°C to 2000°C for a contact time of 0.5 to 5 seconds wherein at least a portion of the tar undergoes at least partial oxidation and/or cracking to produce a hot syngas; wherein the gas mixture from the first reaction zone changes direction of flow by impingement on a surface. contacting said tar containing syngas with a molecular oxygen containing gas in a first reaction zone to produce a gas mixture; and passing said gas mixture through a heat treatment zone maintained at a temperature between 900°C to 2000°C for a contact time of 0.5 to 5 seconds wherein at least a portion of the tar undergoes at least partial oxidation and/or cracking to produce a hot syngas; wherein the gas mixture from the first reaction zone changes direction of flow by impingement on a surface.
A method for improving the cosmetic appearance of mammalian epidermal cells, comprising the use of a compound of formula or a pharmaceutically acceptable salt thereof: wherein R 6 is furfuryl, methoxy-substituted furfuryl, phenyl, methoxy-substituted phenyl or methoxy-substituted benzyl, and R 9 is 2-tetrahydropyranyl or 2-tetrahydrofuranyl.
Powdered catalyst material on titanium oxide basis, having a combined content of at least 90% by weight hydrated titanium oxide having the general formula TiO (2-x) 2x with 0 < x ≤ 1, particularly 0.1 < x ≤ 1, calculated as TiO 2, and silicon dioxide including hydrated precursors thereof, calculated as SiO 2, which has a specific surface area of > 300 m 2 /g, determined using N 2 porosimetry as described in the description, and an isoelectric point in the range from 4.5 - 5.9, determined as described in the description, wherein the TiO 2 /SiO 2 weight ratio, determined respectively for TiO 2 and SiO 2 is at least 3, preferably at least 5, and less than 30, preferably less than 25, and the percentages by weight are relative to the total weight of the catalyst material after it has been dried at 105 °C for at least 2 hours.
A method for the manufacture of a homogeneous, solid, particulate, urea-based material comprising elemental sulphur, the method comprising the steps of: (a) providing a first liquid flow comprising a urea-based base material at a first temperature at least at or above the melting temperature of the urea-based base material; (b) providing a second liquid flow comprising elemental sulphur at a second temperature at least at or above the melting temperature of the elemental sulphur; (c) continuously joining the first flow with the second flow to form a third flow at a third temperature at which both flows are liquid, such that elemental sulphur in the resulting inhomogeneous melt of molten urea-based base material and molten elemental sulphur is in liquid form; and (d) spraying the inhomogeneous melt, provided in step (c), in a urea fluidized bed granulator using spraying means comprising at least one atomization nozzle operated at less than 2 bar; wherein the residence time of the third flow between the steps of joining (c) and spraying (d) is in the order of 10 to 100 seconds; such that the melt is solidified into homogeneous, solid, particulate urea-based material comprising solid elemental sulphur phases therein. (a) providing a first liquid flow comprising a urea-based base material at a first temperature at least at or above the melting temperature of the urea-based base material; (b) providing a second liquid flow comprising elemental sulphur at a second temperature at least at or above the melting temperature of the elemental sulphur; (c) continuously joining the first flow with the second flow to form a third flow at a third temperature at which both flows are liquid, such that elemental sulphur in the resulting inhomogeneous melt of molten urea-based base material and molten elemental sulphur is in liquid form; and (d) spraying the inhomogeneous melt, provided in step (c), in a urea fluidized bed granulator using spraying means comprising at least one atomization nozzle operated at less than 2 bar; wherein the residence time of the third flow between the steps of joining (c) and spraying (d) is in the order of 10 to 100 seconds; such that the melt is solidified into homogeneous, solid, particulate urea-based material comprising solid elemental sulphur phases therein.
A laser device comprising: a vertical external cavity surface emitting laser device a first container with an internal space accommodating the vertical external cavity surface emitting laser device, wherein said first container hermetically seals said internal space from an external space, wherein said first container comprises at least one container wall with at least one first through-opening, wherein said at least one first through-opening is adapted for passage of an optical pump beam from the external space into the internal space, characterized in that a sealing mirror is located in said internal space and extends over the entire first through-opening, wherein said at least one first through-opening is hermetically sealed by said sealing mirror such that said first through-opening with said sealing mirror is an entrance for said optical pump beam, and wherein said sealing mirror is adapted to form part of an external cavity of the vertical external cavity surface emitting laser device in the internal space. a vertical external cavity surface emitting laser device a first container with an internal space accommodating the vertical external cavity surface emitting laser device, wherein said first container hermetically seals said internal space from an external space, wherein said first container comprises at least one container wall with at least one first through-opening, wherein said at least one first through-opening is adapted for passage of an optical pump beam from the external space into the internal space, wherein said first container hermetically seals said internal space from an external space, wherein said first container comprises at least one container wall with at least one first through-opening, wherein said at least one first through-opening is adapted for passage of an optical pump beam from the external space into the internal space, characterized in that a sealing mirror is located in said internal space and extends over the entire first through-opening, wherein said at least one first through-opening is hermetically sealed by said sealing mirror such that said first through-opening with said sealing mirror is an entrance for said optical pump beam, and wherein said sealing mirror is adapted to form part of an external cavity of the vertical external cavity surface emitting laser device in the internal space.
A payout tube (100,200) for facilitating payout of filamentary material from a coil of filamentary material wound in a figure-eight configuration and defining a payout hole, the payout hole extending from an inner wind of the coil to an outer wind of the coil, the payout tube comprising: an outer ring having a flange (106, 206) at an outer end of the payout tube, the outer ring centered about a longitudinal axis; an inner ring having a rounded edge (112, 212) at an inner end of the payout tube, wherein the inner ring is aligned coaxially with the outer ring and is spaced longitudinally from the outer ring; and a plurality of pillars spaced from one another and extending longitudinally from the outer ring to the inner ring. an outer ring having a flange (106, 206) at an outer end of the payout tube, the outer ring centered about a longitudinal axis; an inner ring having a rounded edge (112, 212) at an inner end of the payout tube, wherein the inner ring is aligned coaxially with the outer ring and is spaced longitudinally from the outer ring; and a plurality of pillars spaced from one another and extending longitudinally from the outer ring to the inner ring.
Use of an apparatus including: (a) a sandwich core setup comprising: a substrate that is rigid enough to avoid any deformation by the contraction stress of curing; a rigid ring-shaped spacer placed on the rigid substrate; and a glass cover slip having a thickness of from 0.01 mm to 1.00mm, which is centered on the spacer; (b) a secondary setup to ensure reproducibility, comprising: a supporting bed holding the substrate placed on top of the supporting bed; a ride-on part comprising a test well which is placed on top of the rigid substrate and spacer, a light guide piece set in the well portion of the ride-on part, on which light guide piece a curing light may sit on top of a placed curable material or specimen without touching the cover slip; the light guide piece is adapted to serve as a light-guide holder; and a base capable of stabilizing the supporting bed aligned with the base, for visualizing contraction stress of any curable material during the course of curing or immediately after such a curing process when the curable material having high contraction stress causes the glass cover slip of the apparatus to be cracked or to completely break apart. (a) a sandwich core setup comprising: a substrate that is rigid enough to avoid any deformation by the contraction stress of curing; a rigid ring-shaped spacer placed on the rigid substrate; and a glass cover slip having a thickness of from 0.01 mm to 1.00mm, which is centered on the spacer; a substrate that is rigid enough to avoid any deformation by the contraction stress of curing; a rigid ring-shaped spacer placed on the rigid substrate; and a glass cover slip having a thickness of from 0.01 mm to 1.00mm, which is centered on the spacer; (b) a secondary setup to ensure reproducibility, comprising: a supporting bed holding the substrate placed on top of the supporting bed; a ride-on part comprising a test well which is placed on top of the rigid substrate and spacer, a light guide piece set in the well portion of the ride-on part, on which light guide piece a curing light may sit on top of a placed curable material or specimen without touching the cover slip; the light guide piece is adapted to serve as a light-guide holder; and a base capable of stabilizing the supporting bed aligned with the base, a supporting bed holding the substrate placed on top of the supporting bed; a ride-on part comprising a test well which is placed on top of the rigid substrate and spacer, a light guide piece set in the well portion of the ride-on part, on which light guide piece a curing light may sit on top of a placed curable material or specimen without touching the cover slip; the light guide piece is adapted to serve as a light-guide holder; and a base capable of stabilizing the supporting bed aligned with the base,
A yarn defect classifying device used in a yarn winding machine including a yarn supplying device (2, 3) adapted to supply a yarn, a winding device adapted to wind the yarn into a package, and a yarn defect removal device adapted to remove a yarn defect of the yarn between the yarn supplying device (2, 3) and the winding device, the yarn defect classifying device comprising: a yarn defect detecting device adapted to detect the yarn defect between the yarn supplying device (2, 3) and the winding device; a plurality of removal determination sections (24; 53N, 53S, 53L) adapted to calculate a removal determination value for a set length of the yarn in accordance with a detected thickness of the yarn defect detected by the yarn defect detecting device, and to remove the yarn defect by the yarn defect removal device when the removal determination value exceeds a prescribed value; a plurality of calculating sections (24; 54N, 54S, 54L) adapted to calculate a display thickness of the yarn defect and a display length of the yarn defect in accordance with the detected thickness and a detected length of the yarn defect, characterized in that a different set length is set for each of the removal determination sections (24; 53N, 53S, 53L). a yarn defect detecting device adapted to detect the yarn defect between the yarn supplying device (2, 3) and the winding device; a plurality of removal determination sections (24; 53N, 53S, 53L) adapted to calculate a removal determination value for a set length of the yarn in accordance with a detected thickness of the yarn defect detected by the yarn defect detecting device, and to remove the yarn defect by the yarn defect removal device when the removal determination value exceeds a prescribed value; a plurality of calculating sections (24; 54N, 54S, 54L) adapted to calculate a display thickness of the yarn defect and a display length of the yarn defect in accordance with the detected thickness and a detected length of the yarn defect, characterized in that a different set length is set for each of the removal determination sections (24; 53N, 53S, 53L).
A method for selectively serving either one sector in an N sector system or two sectors in a 2·N sector system, where N≥1, and using an antenna array comprising at least 4 antenna columns (40a, 40b, 40K), each antenna column comprising physical antenna elements (31, 32), the method comprising: generating at least one virtual antenna port pair per sector using the physical antenna elements, wherein each virtual antenna port in said at least one virtual antenna port pair is obtained by combining physical antenna elements having orthogonal polarization such that two virtual antenna ports in each virtual antenna port pair have identical power radiation patterns and orthogonal polarizations, wherein at least one antenna element per polarization has a non-zero beamforming weight, and wherein there are K antenna columns, and wherein non-zero beamforming weights for the antenna elements of the antenna columns are determined such that a k 2 + a K − k 2 = c where a k denotes the non-zero beamforming weight for the antenna elements of antenna column k and where c # 0 is a constant; and transmitting signals using said at least one virtual antenna port pair per sector in said one sector in the N sector system or in said two sectors in the 2·N sector system. generating at least one virtual antenna port pair per sector using the physical antenna elements, wherein each virtual antenna port in said at least one virtual antenna port pair is obtained by combining physical antenna elements having orthogonal polarization such that two virtual antenna ports in each virtual antenna port pair have identical power radiation patterns and orthogonal polarizations, wherein at least one antenna element per polarization has a non-zero beamforming weight, and wherein there are K antenna columns, and wherein non-zero beamforming weights for the antenna elements of the antenna columns are determined such that a k 2 + a K − k 2 = c where a k denotes the non-zero beamforming weight for the antenna elements of antenna column k and where c # 0 is a constant; and transmitting signals using said at least one virtual antenna port pair per sector in said one sector in the N sector system or in said two sectors in the 2·N sector system.
A haptic peripheral comprising: a housing (116, 916) including a frame (138, 1138) having a plurality of spaced apart windows; a plurality of deformable membranes (122, 922, 1022, 1222), each deformable membrane (122, 922, 1022, 1222) positioned within one of the plurality of spaced apart windows of the frame (138, 1138); and a haptic output device disposed within the housing (116, 916) and coupled to the plurality of deformable membranes (122, 922, 1022, 1222), the haptic output device including a motor (124, 924, 1124), a converter, and a plurality of radially-extending pins (136, 936, 1036, 1136, 1236), the converter extending between the motor (124, 924, 1124) and the plurality of radially-extending pins (136, 936, 1036, 1136, 1236) and each radially-extending pin (136, 936, 1036, 1136, 1236) having a first end attached to the converter and a second opposing end attached to one of the deformable membranes (122, 922, 1022, 1222), wherein the motor (124, 924, 1124) is configured to receive a control signal from a processor and is configured to rotate relative to the housing (116, 916) in response to the control signal from the processor and the converter is configured to convert rotary motion of the motor (124, 924, 1124) to linear motion to move the plurality of radially-extending pins (136, 936, 1036, 1136, 1236) to thereby radially extend the deformable membranes (122, 922, 1022, 1222) relative to the housing (116, 916) and provide a haptic effect to a user of the haptic peripheral. a housing (116, 916) including a frame (138, 1138) having a plurality of spaced apart windows; a plurality of deformable membranes (122, 922, 1022, 1222), each deformable membrane (122, 922, 1022, 1222) positioned within one of the plurality of spaced apart windows of the frame (138, 1138); and a haptic output device disposed within the housing (116, 916) and coupled to the plurality of deformable membranes (122, 922, 1022, 1222), the haptic output device including a motor (124, 924, 1124), a converter, and a plurality of radially-extending pins (136, 936, 1036, 1136, 1236), the converter extending between the motor (124, 924, 1124) and the plurality of radially-extending pins (136, 936, 1036, 1136, 1236) and each radially-extending pin (136, 936, 1036, 1136, 1236) having a first end attached to the converter and a second opposing end attached to one of the deformable membranes (122, 922, 1022, 1222), wherein the motor (124, 924, 1124) is configured to receive a control signal from a processor and is configured to rotate relative to the housing (116, 916) in response to the control signal from the processor and the converter is configured to convert rotary motion of the motor (124, 924, 1124) to linear motion to move the plurality of radially-extending pins (136, 936, 1036, 1136, 1236) to thereby radially extend the deformable membranes (122, 922, 1022, 1222) relative to the housing (116, 916) and provide a haptic effect to a user of the haptic peripheral.
A method for generating a z-effective value for a set of voxels in a CT density image for a radiography imaging modality, comprising: acquiring the CT density image of an object; acquiring sparse multi-energy projection data of the object; identifying one or more sets of voxels in the CT density image; setting an initial z-effective value for respective sets of voxels to generate a CT z-effective image; forward projecting the CT z-effective image to generate synthetic multi-energy projection data; comparing the synthetic multi-energy projection data to the sparse multi-energy projection data to determine a measure of similarity between z-effective information of the synthetic multi-energy projection data and z-effective information of the sparse multi-energy projection data; and updating the initial z-effective value for one or more sets of voxels to update the CT z-effective image when the determined measure of similarity between the z-effective information of the synthetic multi-energy projection data and the z-effective information of the sparse multi-energy projection data is below a specified threshold. acquiring the CT density image of an object; acquiring sparse multi-energy projection data of the object; identifying one or more sets of voxels in the CT density image; setting an initial z-effective value for respective sets of voxels to generate a CT z-effective image; forward projecting the CT z-effective image to generate synthetic multi-energy projection data; comparing the synthetic multi-energy projection data to the sparse multi-energy projection data to determine a measure of similarity between z-effective information of the synthetic multi-energy projection data and z-effective information of the sparse multi-energy projection data; and updating the initial z-effective value for one or more sets of voxels to update the CT z-effective image when the determined measure of similarity between the z-effective information of the synthetic multi-energy projection data and the z-effective information of the sparse multi-energy projection data is below a specified threshold.
A method for making a derivative of a GLP-1 analogue comprising one or more non-proteogenic amino acids in the N-terminal part, said method comprising the steps of: (i) culturing a host cell comprising a nucleotide sequence encoding a precursor molecule of said GLP-1 analogue under suitable conditions for expression of said precursor molecule; (ii) separating the expressed precursor molecule from the culture broth; (iii) acylating the epsilon-amino-group of one lysine residue in the expressed precursor molecule with an acylating agent, which is optionally activated, to obtain a precursor molecule derivative, and optionally isolating said precursor molecule derivative; (iv) coupling an N-terminal amino acid extension comprising one or more non-proteogenic amino acids to the expressed precursor molecule derivative; and (v) isolating the resulting derivative of a GLP-1 analogue by suitable means; wherein (a) said acylation step (iii) takes place in an aqueous solvent mixture with a pH between 9 and 13; (b) said N-terminal extension has a length of 2 or 4 amino acids, and (c) said resulting derivative of a GLP-1 analogue is N-epsilon26-[2-(2-{2-[2-(2-{2-[ -4-Carboxy-4-(17-carboxy-heptadecanoylamino)-butyrylamino]ethoxy}ethoxy)acetylamino]-ethoxy}ethoxy)-acetyl][Aib8,Arg34]GLP-1- peptide. (i) culturing a host cell comprising a nucleotide sequence encoding a precursor molecule of said GLP-1 analogue under suitable conditions for expression of said precursor molecule; (ii) separating the expressed precursor molecule from the culture broth; (iii) acylating the epsilon-amino-group of one lysine residue in the expressed precursor molecule with an acylating agent, which is optionally activated, to obtain a precursor molecule derivative, and optionally isolating said precursor molecule derivative; (iv) coupling an N-terminal amino acid extension comprising one or more non-proteogenic amino acids to the expressed precursor molecule derivative; and (v) isolating the resulting derivative of a GLP-1 analogue by suitable means; (a) said acylation step (iii) takes place in an aqueous solvent mixture with a pH between 9 and 13; (b) said N-terminal extension has a length of 2 or 4 amino acids, and (c) said resulting derivative of a GLP-1 analogue is N-epsilon26-[2-(2-{2-[2-(2-{2-[ -4-Carboxy-4-(17-carboxy-heptadecanoylamino)-butyrylamino]ethoxy}ethoxy)acetylamino]-ethoxy}ethoxy)-acetyl][Aib8,Arg34]GLP-1- peptide.