mhurhangee/ep-ind-claims huggingface dataset:
Apparatus for characterizing an electrocardiogram, comprising: a probe which is configured to receive a first unipolar signal from a first location of a heart and a second unipolar signal from a second location of the heart; and a processor which is configured to generate a bipolar signal from the first and second unipolar signals (212, 214), wherein the processor is further configured to: analyze the bipolar signal to delineate a time period during which the first and second locations (23, 25) generate a QRS bipolar complex, wherein delineating the time period comprises feeding data of the bipolar signal into a two-state state machine so as to determine bounds of the time period, and analyze the first unipolar signal within the time period to determine an activation time of the first location. a probe which is configured to receive a first unipolar signal from a first location of a heart and a second unipolar signal from a second location of the heart; and a processor which is configured to generate a bipolar signal from the first and second unipolar signals (212, 214), analyze the bipolar signal to delineate a time period during which the first and second locations (23, 25) generate a QRS bipolar complex, wherein delineating the time period comprises feeding data of the bipolar signal into a two-state state machine so as to determine bounds of the time period, and analyze the first unipolar signal within the time period to determine an activation time of the first location.
A composition comprising a physiologically effective amount of S-adenosylmethionine (SAMe), wherein said composition is in a dosage form having an in vitro dissolution of 25 to 80% release of SAMe after 60 minutes in an aqueous buffer of pH 6.0, wherein the composition is formulated for oral administration, and wherein the composition comprises a suitable excipient; wherein the composition is in a dosage form that comprises a functional coating and the functional coating constitutes from 1 to 5% of the total weight of the dosage form; and wherein the in vitro dissolution may be determined using a USP (US Pharmacopeia) Dissolution Apparatus II operated at 100RPM, by the steps of: (a) exposing the composition to 1L of USP Simulated Gastric Fluid without enzyme at pH 1.2, 37°C for 2 hours (b) transferring the composition to 1L of USP Simulated Intestinal Fluid without enzyme, at pH 6.0, 37°C (c) drawing samples at prescribed intervals (d) diluting each sample 1→ 10 with n/10 HCl, and (e) determining the drug concentration spectrophotometrically at 258nm. (a) exposing the composition to 1L of USP Simulated Gastric Fluid without enzyme at pH 1.2, 37°C for 2 hours (b) transferring the composition to 1L of USP Simulated Intestinal Fluid without enzyme, at pH 6.0, 37°C (c) drawing samples at prescribed intervals (d) diluting each sample 1→ 10 with n/10 HCl, and (e) determining the drug concentration spectrophotometrically at 258nm.
A compound which is RAD140 (Compound III): a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, for use in a method treating AR+/ER+ breast cancer.
A method for attaching an electrode to cabling, comprising: providing a cable comprising a plurality of insulated wires coiled around a central core, wherein the wires are covered with a sheath, and wherein the sheath is transparent, and an insulating layer of at least one of the plurality of insulated wires is colored differently from the colors of insulating layers of the remaining plurality of insulated wires; selecting a location for attaching a respective electrode by finding a colored insulated wire visually from the plurality of insulated wires, and then finding a required location for the respective electrode along the cabling; removing a section of the sheath and removing a corresponding section of insulation from the colored insulated wire in a set of the coiled wires, wherein the section of the sheath is removed from above the wire, so as to provide a respective access channel through the sheath and through the insulation to a respective section of a respective conductor of the wire in the set while the respective section remains coiled on the central core; and fastening the respective electrode to the respective access channel while the respective section remains coiled on the central core, wherein the method further comprises positioning a solder ball in proximity to the respective access channel prior to fastening the respective electrode, and wherein fastening the respective electrode comprises melting the solder ball so that solidified solder connects the respective section of the respective conductor, via the respective access channel, to the respective electrode. providing a cable comprising a plurality of insulated wires coiled around a central core, wherein the wires are covered with a sheath, and wherein the sheath is transparent, and an insulating layer of at least one of the plurality of insulated wires is colored differently from the colors of insulating layers of the remaining plurality of insulated wires; selecting a location for attaching a respective electrode by finding a colored insulated wire visually from the plurality of insulated wires, and then finding a required location for the respective electrode along the cabling; removing a section of the sheath and removing a corresponding section of insulation from the colored insulated wire in a set of the coiled wires, wherein the section of the sheath is removed from above the wire, so as to provide a respective access channel through the sheath and through the insulation to a respective section of a respective conductor of the wire in the set while the respective section remains coiled on the central core; and fastening the respective electrode to the respective access channel while the respective section remains coiled on the central core, wherein the method further comprises positioning a solder ball in proximity to the respective access channel prior to fastening the respective electrode, and wherein fastening the respective electrode comprises melting the solder ball so that solidified solder connects the respective section of the respective conductor, via the respective access channel, to the respective electrode.
A multilayer structure circular knit fabric composed of a single circular knit having a layer structure of two or more layers, wherein the circular knit fabric is obtained by plating using a single circular knitting machine and by subjecting the circular knit fabric to moisture absorbing processing, and wherein the circular knit fabric has a section where a cellulose-based continuous fiber (a) and a hydrophobic fiber (b) form the same knit loop, the circular knit fabric contains 10% by weight to 50% by weight of the cellulose-based continuous fiber (a), wherein the cellulose-based continuous fiber (a) has a single yarn fineness of 0.1 dtex to 7.0 dtex, determined as described in the description, and wherein a cool touch sensation of the circular knit fabric of a skin-side layer adapted to be in contact with the wearer is 100 W/m2/°C to 200 W/m2/ °C, determined as described in the description, characterized in that the circular knit fabric has an exposure percentage of the cellulose-based continuous fiber (a) in a region within 0.13 mm towards an inside of the knit fabric from the surface of the skin-side layer adapted to be in contact with the wearer when used as clothing of 30% or more, determined as described in the description, and a time it takes for the moisture percentage of the circular knit fabric to reach 10% after having dropped 0.3 cm 3 of water onto the circular knit fabric of 50 minutes or less, determined as described in the description.
An industrial safety controller comprising: a processing unit having a processor executing instructions, and a memory holding instructions and data, the processing unit providing a hardware lock preventing writing of at least a portion of the memory as controllable by a lock instruction wherein the memory is adapted to hold a standard program and safety program, the safety program requires higher reliability execution than the standard program; characterized in that the controller further comprises: a lock management program executable on the processing unit which unlocks a portion ot memory holding the safety program when the safety program starts executing and which locks the portion of memory at conclusion of the safety program, wherein the portion of memory is in a read/write status when unlocked and the portion of memory is in a read only status when locked; and a lock check program which periodically checks the status of the portion of memory holding the safety program when a safety program is not executing and invokes a safety state if the hardware lock of the portion of memory holding the safety program is not in place. a processing unit having a processor executing instructions, and a memory holding instructions and data, the processing unit providing a hardware lock preventing writing of at least a portion of the memory as controllable by a lock instruction wherein the memory is adapted to hold a standard program and safety program, the safety program requires higher reliability execution than the standard program; a lock management program executable on the processing unit which unlocks a portion ot memory holding the safety program when the safety program starts executing and which locks the portion of memory at conclusion of the safety program, wherein the portion of memory is in a read/write status when unlocked and the portion of memory is in a read only status when locked; and wherein the portion of memory is in a read/write status when unlocked and the portion of memory is in a read only status when locked; and a lock check program which periodically checks the status of the portion of memory holding the safety program when a safety program is not executing and invokes a safety state if the hardware lock of the portion of memory holding the safety program is not in place.
Container for spray for a back-mounted sprayer, wherein the container (7, 47, 97, 107) has a filling hole, which can be closed by a cover (23, 48), wherein the container (7, 47, 97, 107) has a spray region provided for spray, which extends to a maximum permissible fill level (max), and wherein the spray region has a largest horizontal internal cross-section area in a parking position of the sprayer, characterised in that the container (7, 47, 97, 107) can be opened across at least 60% of its largest internal cross-section area at the filling hole, in that a seal, which, if the cover (23, 48) is closed, is located in a reception space formed between the cover (23, 48) and the container (7, 47, 97, 107), acts between the cover (23, 48) and the container (7, 47, 97, 107), and in that the seal is supported with an axial sealing face on a continuous edge of the container (7, 47, 97, 107), which edge drops towards the container interior.
A bidirectional low voltage power supply 'LVPS' comprising: a first power converter (120, 320) arranged to provide power from an input power source (110, 310) to a load; a second power converter arranged to selectively recycle power from the load at an output of the first power converter (120, 320) back to the input power source (110, 310); and control circuitry (140, 240, 340) comprising a single pulse width modulator 'PWM' and switching circuitry (175, 275), the switching circuitry configured to select either the first power converter or the second power converter for reception of the output of the PWM, the control circuitry (140, 240, 340) further comprising an error amplifier (150, 250) receiving the power supply output voltage (V O) and a reference voltage (V REF), an absolute value circuit configured to provide to the pulse width modulator an absolute value of a difference between the output of the error amplifier and zero volts; and a converter selection comparator (170, 270) connected to the output of the error amplifier and configured to cause the switching circuitry to switch the output of the PWM between the first power converter (130, 230) and the second power converter (110, 310). a first power converter (120, 320) arranged to provide power from an input power source (110, 310) to a load; a second power converter arranged to selectively recycle power from the load at an output of the first power converter (120, 320) back to the input power source (110, 310); and control circuitry (140, 240, 340) comprising a single pulse width modulator 'PWM' and switching circuitry (175, 275), the switching circuitry configured to select either the first power converter or the second power converter for reception of the output of the PWM, the control circuitry (140, 240, 340) further comprising an error amplifier (150, 250) receiving the power supply output voltage (V O) and a reference voltage (V REF), an absolute value circuit configured to provide to the pulse width modulator an absolute value of a difference between the output of the error amplifier and zero volts; and a converter selection comparator (170, 270) connected to the output of the error amplifier and configured to cause the switching circuitry to switch the output of the PWM between the first power converter (130, 230) and the second power converter (110, 310).
A center pillar structure comprising: a center pillar including a center pillar outer panel that extends in a vehicle height direction on a side portion of a vehicle, the center pillar outer panel constituting an outer side of the center pillar in a vehicle width direction, wherein the center pillar outer panel includes a pillar upper portion that constitutes an upper portion of the center pillar outer panel and is bonded to a roof side rail that extends in a vehicle front-rear direction; and a pillar lower portion that constitutes a lower portion of the center pillar outer panel and is bonded to a rocker that extends in the vehicle front-rear direction, wherein the pillar lower portion includes a pillar lower main body portion having a tensile strength which is lower than a tensile strength of the pillar upper portion, and a high-strength portion that is disposed on the pillar lower portion and extends in the vehicle height direction, the high-strength portion having a tensile strength which is higher than the tensile strength of the pillar lower main body portion. a center pillar including a center pillar outer panel that extends in a vehicle height direction on a side portion of a vehicle, the center pillar outer panel constituting an outer side of the center pillar in a vehicle width direction, wherein the center pillar outer panel includes a pillar upper portion that constitutes an upper portion of the center pillar outer panel and is bonded to a roof side rail that extends in a vehicle front-rear direction; and a pillar lower portion that constitutes a lower portion of the center pillar outer panel and is bonded to a rocker that extends in the vehicle front-rear direction, wherein the pillar lower portion includes a pillar lower main body portion having a tensile strength which is lower than a tensile strength of the pillar upper portion, and a high-strength portion that is disposed on the pillar lower portion and extends in the vehicle height direction, the high-strength portion having a tensile strength which is higher than the tensile strength of the pillar lower main body portion.
Electronic device suitable for use on board a spacecraft, comprising at least one motherboard electrically connected to daughterboards (3a, 3b, 3c), said motherboard and said daughterboards each comprising a support plate (4a, 4b, 4c, 5) in order to form a printed circuit board, each plate extending in a respective main plane, each daughterboard (3a, 3b, 3c) comprises at least one first electrical connector (6a, 6b, 6c, 6d) fixed to its plate and the motherboard comprises a corresponding number of second connectors (7a, 7b, 7c, 7d) fixed to the plate of the motherboard, each first connector (6a, 6b, 6c, 6d) engaging with one of the second connectors (7a, 7b, 7c, 7d), characterized in that said first connector (6a, 6b, 6c, 6d) of each daughterboard being arranged on a portion of the plate forming a tab capable of deflection relative to the main plane of the printed circuit board, each tab having at its end a solid portion supporting said first connector and further comprising cavities for increasing the flexibility of the tab.
A compound comprising at least three functionalities, namely (a) a sulfonate group or a sulfate group of the formula - d -SO 3 M with d = 0 or 1 and with M = hydrogen or a monovalent metal cation or the corresponding portion of a multivalent metal cation; (b) a (meth)acryl residue; and (c) either a carboxylic acid function and/or a thioether group; with the proviso that, when the compound is free of silicon, a sulfonate group or sulfate group and a (meth)acryl residue are separated from each other by a hydrocarbon-containing residue having a carbon chain which either is interrupted by O, S, or NH or contains a linking group.
Daytime running lighting assembly for a motor vehicle, said assembly comprising a light module comprising a source of light rays installed in a housing which is closed by a glass and at least part of a bumper comprising a reinforcement surmounted by a skin, said reinforcement being provided with at least one fixing stud cooperating with a fixing lug of the housing and said skin having an opening into which the light module is inserted, characterized in that the glass rests on each side at least against a bearing surface formed by a fold of the skin at the edge of the opening which extends towards the inside of the opening and in that a lug projecting from the glass is inserted into a slot of the fold.
An acid functional compound comprising i. at least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one acidic group which is selected from the group consisting of a phosphoric acid group, an acidic phosphoric acid ester group, a sulfonic acid group, an acidic sulfonic acid ester group and a carboxylic acid group, wherein the at least one acidic group is covalently linked to the at least one segment. i. at least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one acidic group which is selected from the group consisting of a phosphoric acid group, an acidic phosphoric acid ester group, a sulfonic acid group, an acidic sulfonic acid ester group and a carboxylic acid group, wherein the at least one acidic group is covalently linked to the at least one segment.
An ion source apparatus comprising: (a) an anode comprising an anode body, magnetic shunts inwardly extending from the anode body toward an ion emission axis, permanent magnets located between the magnetic shunts in a stacked arrangement in the direction of the ion emission axis, and an open plasma area being located within a hollow central area of the anode, the magnetic shunts and permanent magnets internally secured within the anode body; (b) a cathode comprising a cap having a single outlet opening therethrough, the outlet opening being aligned with the axis, the outlet opening being configured to allow emission of an ion beam from the hollow central area of the anode; (c) magnetic flux lines extending between uppermost and lowermost of the magnetic shunts, the magnetic flux lines including a central outward dip adjacent a middle of the magnetic shunts, the dip of the magnetic flux lines being in the open plasma area, and the dip changing movement of electrons adjacent the dip to increase ionization within a plasma inside the anode; (d) the permanent magnets and the magnetic shunts each being of a closed loop shape; and (e) the magnetic shunts inwardly projecting toward the axis further than the permanent magnets. (a) an anode comprising an anode body, magnetic shunts inwardly extending from the anode body toward an ion emission axis, permanent magnets located between the magnetic shunts in a stacked arrangement in the direction of the ion emission axis, and an open plasma area being located within a hollow central area of the anode, the magnetic shunts and permanent magnets internally secured within the anode body; (b) a cathode comprising a cap having a single outlet opening therethrough, the outlet opening being aligned with the axis, the outlet opening being configured to allow emission of an ion beam from the hollow central area of the anode; (c) magnetic flux lines extending between uppermost and lowermost of the magnetic shunts, the magnetic flux lines including a central outward dip adjacent a middle of the magnetic shunts, the dip of the magnetic flux lines being in the open plasma area, and the dip changing movement of electrons adjacent the dip to increase ionization within a plasma inside the anode; (d) the permanent magnets and the magnetic shunts each being of a closed loop shape; and (e) the magnetic shunts inwardly projecting toward the axis further than the permanent magnets.
A bistable genetic toggle switch comprising a pair of mutual repressor genes A and B, and a pair of activator genes A and B forming a positive feedback loop based on modular DNA-binding proteins, wherein (i) the Activator gene A and the Repressor gene B form part of separate expression cassettes each being under the joint control of the same Operator A, wherein the gene coding for Repressor B is activated by Activator A targeting said Operator A, and (ii) the Activator gene B and Repressor gene A form part of separate expression cassettes each being under the joint control of the same Operator B, wherein the gene coding for Repressor A is activated by Activator B targeting said Operator B; and wherein the expression of Activator gene B and Repressor gene A is inhibited by Repressor B targeting Operator B, and the expression of Activator gene A and Repressor gene B is inhibited by Repressor A targeting Operator A. (i) the Activator gene A and the Repressor gene B form part of separate expression cassettes each being under the joint control of the same Operator A, wherein the gene coding for Repressor B is activated by Activator A targeting said Operator A, and (ii) the Activator gene B and Repressor gene A form part of separate expression cassettes each being under the joint control of the same Operator B, wherein the gene coding for Repressor A is activated by Activator B targeting said Operator B;