A polypeptide of formula: wherein: each instance of L 1 is, a straight chain alkylene of 3 to 7 carbon atoms; each instance of L 2 is, a straight chain alkylene of 3 to 7 carbon atoms; each instance of K and M is independently a straight chain alkylene of 1 to 7 carbon atoms; each instance of R a is hydrogen or alkyl of 1 to 6 carbon atoms or acyl, such as COCH 3; each instance of R b is hydrogen or cyclic or acyclic, branched or unbranched aliphatic; each instance of R c, is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; cyclic or acyclic acyl; hydroxyl; thiol; amino; cyano; isocyano; halo; or nitro; each instance of R e is, independently, -R E, wherein each instance of R E is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; acyl; a resin; a suitable hydroxyl, amino, or thiol protecting group; each instance of R f is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; acyl; a resin; a suitable amino protecting group; or R f and R a together form a 5- to 6-membered heterocyclic or heteroaromatic ring; each instance of X AA is, independently, a natural or unnatural amino acid; each instance of x is, independently, an integer between 0 to 3; each instance of y and z is, independently, an integer between 2 to 6; each instance of j is, independently, an integer between 1 to 10; each instance of p is, independently, an integer between 0 to 10; each instance of s and t is, independently, an integer between 0 and 100; and is a double bond or a triple bond. each instance of L 1 is, a straight chain alkylene of 3 to 7 carbon atoms; each instance of L 2 is, a straight chain alkylene of 3 to 7 carbon atoms; each instance of K and M is independently a straight chain alkylene of 1 to 7 carbon atoms; each instance of R a is hydrogen or alkyl of 1 to 6 carbon atoms or acyl, such as COCH 3; each instance of R b is hydrogen or cyclic or acyclic, branched or unbranched aliphatic; each instance of R c, is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; cyclic or acyclic acyl; hydroxyl; thiol; amino; cyano; isocyano; halo; or nitro; each instance of R e is, independently, -R E, wherein each instance of R E is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; acyl; a resin; a suitable hydroxyl, amino, or thiol protecting group; each instance of R f is, independently, hydrogen; cyclic or acyclic, branched or unbranched, substituted or unsubstituted aliphatic; cyclic or acyclic, branched or unbranched, substituted or unsubstituted heteroaliphatic; aryl; heteroaryl; acyl; a resin; a suitable amino protecting group; or R f and R a together form a 5- to 6-membered heterocyclic or heteroaromatic ring; each instance of X AA is, independently, a natural or unnatural amino acid; each instance of x is, independently, an integer between 0 to 3; each instance of y and z is, independently, an integer between 2 to 6; each instance of j is, independently, an integer between 1 to 10; each instance of p is, independently, an integer between 0 to 10; each instance of s and t is, independently, an integer between 0 and 100; and is a double bond or a triple bond.