mhurhangee/ep-ind-claims huggingface dataset:
1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 -one or a pharmaceutically acceptable salt, clathrate, solvate, stereoisomer, tautomer or isotopologue thereof for use in a method for treating E-twenty six overexpressing Ewings sarcoma, the method comprising administering an effective amount of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 -one or a pharmaceutically acceptable salt, clathrate, solvate, stereoisomer, tautomer or isotopologue thereof to a patient having ETS overexpressing Ewings sarcoma.
An apparatus (100, 200) arranged to generate control data for production of a three-dimensional object comprising: a halftone generator to apply a halftoning operation to a digital representation of at least a portion of the three-dimensional object, the halftone generator being arranged to process the digital representation in association with a three-dimensional threshold matrix to output discrete material arrangement instructions for at least one production material; a matrix generator to generate the three-dimensional threshold matrix for use by the halftone generator, the matrix generator characterized by being arranged to: obtain values for a predefined two-dimensional threshold matrix; and extend the two-dimensional threshold matrix into a third dimension to generate the three-dimensional threshold matrix by laterally-shifting, with respect to the third dimension and according to a defined sequence, subsequent matrices in a set of two-dimensional matrices, each matrix in the set of two-dimensional matrices comprising at least a subset of the values for the predefined two-dimensional threshold matrix. a halftone generator to apply a halftoning operation to a digital representation of at least a portion of the three-dimensional object, the halftone generator being arranged to process the digital representation in association with a three-dimensional threshold matrix to output discrete material arrangement instructions for at least one production material; a matrix generator to generate the three-dimensional threshold matrix for use by the halftone generator, the matrix generator characterized by being arranged to: obtain values for a predefined two-dimensional threshold matrix; and extend the two-dimensional threshold matrix into a third dimension to generate the three-dimensional threshold matrix by laterally-shifting, with respect to the third dimension and according to a defined sequence, subsequent matrices in a set of two-dimensional matrices, each matrix in the set of two-dimensional matrices comprising at least a subset of the values for the predefined two-dimensional threshold matrix. obtain values for a predefined two-dimensional threshold matrix; and extend the two-dimensional threshold matrix into a third dimension to generate the three-dimensional threshold matrix by laterally-shifting, with respect to the third dimension and according to a defined sequence, subsequent matrices in a set of two-dimensional matrices, each matrix in the set of two-dimensional matrices comprising at least a subset of the values for the predefined two-dimensional threshold matrix.
An emergency off-switch for triggering an emergency switch-off function for safety-related shutdown of an electrical device, comprising - an actuation element and at least two electrical contact points (40, 42), which can be connected to one another via a contact bridge, wherein a position of the contact bridge is influenced by the actuation element such that the electrical contact points (40, 42) can be opened and/or closed, - an active operating state, in which the emergency switch-off function can be triggered by moving the contact bridge, and a passive operating state, in which the emergency off-switch is non-functional, - a visualization device having at least a first and a second display state, wherein the emergency off-switch, in particular the actuation element, is visually highlighted in the first display state, and the emergency off-switch is neutrally displayed in the second display state, and the visualization device is further designed to adopt the first display state in the active operating state and to adopt the second display state in the passive operating state, - a monitoring unit, which monitors whether the visualization device is in the first or in the second display state, in order to trigger an action, in particular the emergency switch-off function, in dependence thereof, characterized in that the visualization device has a defined nominal current in the first display state and the monitoring unit triggers the emergency switch-off function, when an actual current flow into the visualization device is less than the defined nominal current. - an actuation element and at least two electrical contact points (40, 42), which can be connected to one another via a contact bridge, wherein a position of the contact bridge is influenced by the actuation element such that the electrical contact points (40, 42) can be opened and/or closed, - an active operating state, in which the emergency switch-off function can be triggered by moving the contact bridge, and a passive operating state, in which the emergency off-switch is non-functional, - a visualization device having at least a first and a second display state, wherein the emergency off-switch, in particular the actuation element, is visually highlighted in the first display state, and the emergency off-switch is neutrally displayed in the second display state, and the visualization device is further designed to adopt the first display state in the active operating state and to adopt the second display state in the passive operating state, - a monitoring unit, which monitors whether the visualization device is in the first or in the second display state, in order to trigger an action, in particular the emergency switch-off function, in dependence thereof,
An organic electronic device comprising a transparent substrate and provided thereon, a first transparent electrode, a second electrode and an organic functional layer provided between the first transparent electrode and the second electrode, wherein: the first transparent electrode and the second electrode are opposed to each other, and a transparent conductive layer comprising a conductive polymer and a resin having a hydrophilic group is provided between the first transparent electrode and the organic functional layer, at least a part of the conductive polymer or the resin having a hydrophilic group is crosslinked, 30 parts by weight to 900 parts by weight of the resin having a hydrophilic group are used when the conductive polymer is set to 100 parts by weight, the conductive polymer comprises a conductive polymer containing a π-conjugated conductive polymer component and a polyanionic component comprising a polysulfonic acid group, and the resin having a hydrophilic group comprises Polymer containing at least one selected from the monomer units represented by the following (A 1), (A 2) and (A 3): and where X 1, X 2 and X 3 each independently represent a hydrogen atom or a methyl group; R 1, R 2 and R 3 each independently represent an alkylene group having 5 carbon atoms or less; and "l", "m" and "n" each represent a component ratio of mol/%, satisfying 50 ≤ l + m + n ≤ 100. the first transparent electrode and the second electrode are opposed to each other, and a transparent conductive layer comprising a conductive polymer and a resin having a hydrophilic group is provided between the first transparent electrode and the organic functional layer, at least a part of the conductive polymer or the resin having a hydrophilic group is crosslinked, 30 parts by weight to 900 parts by weight of the resin having a hydrophilic group are used when the conductive polymer is set to 100 parts by weight, the conductive polymer comprises a conductive polymer containing a π-conjugated conductive polymer component and a polyanionic component comprising a polysulfonic acid group, and the resin having a hydrophilic group comprises Polymer containing at least one selected from the monomer units represented by the following (A 1), (A 2) and (A 3): and
An oral care composition comprising: a. stannous ions; b. a flavor system comprising (i) a mint oil and (ii) a protectant component selected from cis -jasmone, 2,5-dimethyl-4-hydroxy-3 -furanone, 5-ethyl-3-hydroxy-4-methyl-2 -furanone, vanillin, ethyl vanillin, anisaldehyde, cinnamaldehyde and mixtures thereof; and c. orally acceptable carriers; wherein the ratio of protectant component to mint oil is from 2:1 to 1:300 by weight. a. stannous ions; b. a flavor system comprising (i) a mint oil and (ii) a protectant component selected from cis -jasmone, 2,5-dimethyl-4-hydroxy-3 -furanone, 5-ethyl-3-hydroxy-4-methyl-2 -furanone, vanillin, ethyl vanillin, anisaldehyde, cinnamaldehyde and mixtures thereof; and (i) a mint oil and (ii) a protectant component selected from cis -jasmone, 2,5-dimethyl-4-hydroxy-3 -furanone, 5-ethyl-3-hydroxy-4-methyl-2 -furanone, vanillin, ethyl vanillin, anisaldehyde, cinnamaldehyde and mixtures thereof; and c. orally acceptable carriers; wherein the ratio of protectant component to mint oil is from 2:1 to 1:300 by weight.
An indoor unit for an air-conditioning apparatus, comprising: a main body comprising an air inlet and an air outlet; a cross-flow fan arranged inside the main body in a rotatable manner, the cross-flow fan comprising an impeller for causing air to be taken into the main body through the air inlet and causing the air to be blown out through the air outlet; and a stabilizer for partitioning a space inside the main body into an air inlet-side flow passage on an upstream side with respect to the cross-flow fan and an air outlet-side flow passage on a downstream side with respect to the cross-flow fan, wherein the impeller comprises a blade, wherein the blade comprises a step (16, 16', 16") formed between an outer peripheral-side end portion and an inner peripheral-side end portion of the blade on at least one of a suction surface or a pressure surface being surfaces of the blade, and wherein the step (16, 16', 16") is formed so that an inner peripheral-side part with respect to the step is larger in blade thickness than an outer peripheral-side part with respect to the step, characterized in that the step (16, 16', 16") is formed so as to extend obliquely with respect to a rotation axis of the impeller, and to vary in height in relation to the at least one of a suction or a pressure surface of the blade over the longitudinal direction of the blade. a main body comprising an air inlet and an air outlet; a cross-flow fan arranged inside the main body in a rotatable manner, the cross-flow fan comprising an impeller for causing air to be taken into the main body through the air inlet and causing the air to be blown out through the air outlet; and a stabilizer for partitioning a space inside the main body into an air inlet-side flow passage on an upstream side with respect to the cross-flow fan and an air outlet-side flow passage on a downstream side with respect to the cross-flow fan, wherein the impeller comprises a blade, wherein the blade comprises a step (16, 16', 16") formed between an outer peripheral-side end portion and an inner peripheral-side end portion of the blade on at least one of a suction surface or a pressure surface being surfaces of the blade, and wherein the step (16, 16', 16") is formed so that an inner peripheral-side part with respect to the step is larger in blade thickness than an outer peripheral-side part with respect to the step, characterized in that the step (16, 16', 16") is formed so as to extend obliquely with respect to a rotation axis of the impeller, and to vary in height in relation to the at least one of a suction or a pressure surface of the blade over the longitudinal direction of the blade.
A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein: ring A is selected from rings A-1 and A-2 having the structures: wherein the wavy line labeled 1 indicates the point of attachment of ring A to ring B and the wavy line labeled 2 indicates the point of attachment of ring A to W; X is N or CH; Y is H or F; R 1 is H, allcoxy or halogen; wherein when ring B is B-1, wherein the wavy line labeled 3 indicates the point of attachment to ring A and the wavy line labeled 4 indicates the point of attachment to the pyrazolo[1,5-a]pyrimidine ring of Formula I; W is O, NH or CH 2, wherein when ring A is A-2, then W is CH 2; m is 0, 1 or 2; D is carbon, R 2 and R 2a are independently H, F, (1-3 C)alkyl or OH (provided that R 2 and R 2a are not both OH), and R 3 and R 3a are independently H, (1-3 C)alkyl or hydroxy(1-3 C)alkyl, Z is *-NR 4a C(=O)-, wherein the asterisk indicates the point of attachment of Z to the carbon bearing R 3; R 4a is H, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy(1-6C alkyl) or dihydroxy(2-6C alkyl); and R 5 and R 6 are independently H, halogen, OH, alkyl or hydroxy alkyl. ring A is selected from rings A-1 and A-2 having the structures: wherein the wavy line labeled 1 indicates the point of attachment of ring A to ring B and the wavy line labeled 2 indicates the point of attachment of ring A to W; X is N or CH; Y is H or F; R 1 is H, allcoxy or halogen; wherein the wavy line labeled 1 indicates the point of attachment of ring A to ring B and the wavy line labeled 2 indicates the point of attachment of ring A to W; X is N or CH; Y is H or F; R 1 is H, allcoxy or halogen; wherein when ring B is B-1, wherein the wavy line labeled 3 indicates the point of attachment to ring A and the wavy line labeled 4 indicates the point of attachment to the pyrazolo[1,5-a]pyrimidine ring of Formula I; W is O, NH or CH 2, wherein when ring A is A-2, then W is CH 2; m is 0, 1 or 2; D is carbon, R 2 and R 2a are independently H, F, (1-3 C)alkyl or OH (provided that R 2 and R 2a are not both OH), and R 3 and R 3a are independently H, (1-3 C)alkyl or hydroxy(1-3 C)alkyl, Z is *-NR 4a C(=O)-, wherein the asterisk indicates the point of attachment of Z to the carbon bearing R 3; R 4a is H, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy(1-6C alkyl) or dihydroxy(2-6C alkyl); and R 5 and R 6 are independently H, halogen, OH, alkyl or hydroxy alkyl. wherein the wavy line labeled 3 indicates the point of attachment to ring A and the wavy line labeled 4 indicates the point of attachment to the pyrazolo[1,5-a]pyrimidine ring of Formula I; W is O, NH or CH 2, wherein when ring A is A-2, then W is CH 2; m is 0, 1 or 2; D is carbon, R 2 and R 2a are independently H, F, (1-3 C)alkyl or OH (provided that R 2 and R 2a are not both OH), and R 3 and R 3a are independently H, (1-3 C)alkyl or hydroxy(1-3 C)alkyl, Z is *-NR 4a C(=O)-, wherein the asterisk indicates the point of attachment of Z to the carbon bearing R 3; R 4a is H, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy(1-6C alkyl) or dihydroxy(2-6C alkyl); and R 5 and R 6 are independently H, halogen, OH, alkyl or hydroxy alkyl.
An information processing terminal for receiving and reproducing data stream-distributed by an information processing apparatus, comprising: generation means for generating information used by the information processing apparatus to determine whether data to be distributed can be stream-distributed; transmission means for transmitting the information generated by the generation means to the information processing apparatus; receiving means for receiving data stream-distributed by the information processing apparatus; and reproduction means for reproducing the data received by the receiving means, characterized in that: the data received by the receiving means is not-compressed data; and the generation means is configured to generate, as the information, a predetermined amount of data to be used by the information processing apparatus to measure a transfer rate between the information processing terminal and the information processing apparatus. generation means for generating information used by the information processing apparatus to determine whether data to be distributed can be stream-distributed; transmission means for transmitting the information generated by the generation means to the information processing apparatus; receiving means for receiving data stream-distributed by the information processing apparatus; and reproduction means for reproducing the data received by the receiving means, characterized in that: the data received by the receiving means is not-compressed data; and the generation means is configured to generate, as the information, a predetermined amount of data to be used by the information processing apparatus to measure a transfer rate between the information processing terminal and the information processing apparatus. the data received by the receiving means is not-compressed data; and the generation means is configured to generate, as the information, a predetermined amount of data to be used by the information processing apparatus to measure a transfer rate between the information processing terminal and the information processing apparatus.
Cupboard door system composed of at least one door sliding in an upper rail and a lower rail, which system is characterised in that the door is formed by the assembly of at least two panel elements, a main element and at least one auxiliary element, and side trims in at least two portions which are assembled with each other in continuation of a handle, these segments being fitted to the two edges of the assembled panels.
A composite sheet product characterised by: a skin sheet including ultrafine fibers having an average fiber diameter of 0.1 to 10 μm and an elastomer, and a woven or knitted fabric, wherein the skin sheet and the woven or knitted fabric are laminated on each other with a resin layer containing a flame retardant and an adhesive layer interposed therebetween.
Wall element (10; 20; 30; 40; 50; 60; 70) having a substantially rectangular shape with a first and a second side substantially parallel to each other, and a third side extending between said first and second side, said wall element comprising: a first continuous layer of high performance concrete; a second continuous layer of high performance concrete, said second layer is substantially parallel to the first layer; a first elongated load bearing element; a second elongated load bearing element; and a transverse load bearing beam; wherein said first and second load bearing element and the transverse load bearing beam are positioned between the first and the second layer to separate the first and the second layer thereby generating an intermediate space within the element between the first and second layer, said first and second load bearing element are fastened in the first and second layer and extending along the first and the second side of the wall element (10; 20; 30; 40; 50; 60; 70) and said first and second load bearing element comprise reinforcement bars, wherein said transverse load bearing beam is fastened in the first and second layer and extending along the third side of the wall element (10; 20; 30; 40; 50; 60; 70) characterized in that said first and second layer have different thicknesses. a first continuous layer of high performance concrete; a second continuous layer of high performance concrete, said second layer is substantially parallel to the first layer; a first elongated load bearing element; a second elongated load bearing element; and a transverse load bearing beam;
RFID tag comprising a multimode resonator (1102; 1302), wherein the multimode resonator comprises: two sets of composite transmission lines (101; 102; 103; 104; 201; 202; 203; 204; 205) each set having an equal electric length and including "N" transmission lines (101; 102; 103; 104; 201; 202; 203; 204; 205) in which "N" refers to positive integers, each having either of "m" specific discrete values for the transmission line characteristic impedance, in which "m" refers to two or more positive integers, and connected in series, said two sets of composite transmission lines (101; 102; 103; 104; 201; 202; 203; 204; 205) being so connected at the center as to form a symmetrical electric circuit configuration and having the opposite terminals one of which is an open-circuited end (106; 107; 705) and the other of which is a short-circuited end (206; 207), the "N"th-order's higher-order mode resonance frequency being designated as the reference frequency f N and the line electric length being equal to 90 degrees, characterized in that "N" being four or above and wherein the RFID tag allow each of "m N " codes to be assigned to each of the "m N " structures of the resonator (501; 604) that are produced by combinations of the line impedances of the transmission lines (101; 102; 103; 104; 201; 202; 203; 204; 205), and allow each of those codes to be identified by detecting each of the combinations of the "N" higher-order mode resonance frequencies ranging between from {(k-1) • N+1}th-order to (k • N)th-order in which k refers to one or more positive integers, that are produced for each of the structures of the resonator (501; 604) that corresponds to each of the codes.
A process for preparing resorbable polyesters by bulk polymerization, wherein: - the reaction components are melted and homogenized in a reactor to form a reaction mixture; - the reaction mixture is then transferred into a polymerization reactor having multiple connected plate shaped lumens, each defined by a reactor wall, wherein each of said reactor walls comprises at least two components which are releasably fitted to each other and wherein the shortest distance of any point within said lumen to the reactor wall is less than 8 cm, - the reaction mixture is polymerized and - the resulting polymer is removed from the polymerization reactor by releasing the components of the reactor wall exposing the resulting polymer lengthwise. - the reaction components are melted and homogenized in a reactor to form a reaction mixture; - the reaction mixture is then transferred into a polymerization reactor having multiple connected plate shaped lumens, each defined by a reactor wall, wherein each of said reactor walls comprises at least two components which are releasably fitted to each other and wherein the shortest distance of any point within said lumen to the reactor wall is less than 8 cm, - the reaction mixture is polymerized and - the resulting polymer is removed from the polymerization reactor by releasing the components of the reactor wall exposing the resulting polymer lengthwise.
Method for preparing activated nano carbon from food waste material comprising the steps: (a) crushing the food waste material and sieving through up to 500 microns sieve to obtain a food waste material powder; (b) impregnating the food waste material powder with an impregnation agent; (c) activating the impregnated food waste material powder obtained in step (b) in the presence of an activating gas at a temperature of 500 to 800°C; (d) cryo-grinding of the activated food waste material powder obtained in step (c) to result in activated nanocarbon having a particle size of 10-100 nanometer. (a) crushing the food waste material and sieving through up to 500 microns sieve to obtain a food waste material powder; (b) impregnating the food waste material powder with an impregnation agent; (c) activating the impregnated food waste material powder obtained in step (b) in the presence of an activating gas at a temperature of 500 to 800°C; (d) cryo-grinding of the activated food waste material powder obtained in step (c) to result in activated nanocarbon having a particle size of 10-100 nanometer.