mhurhangee/ep-ind-claims huggingface dataset:
A compound of to formula I wherein Y is a group selected from R 1 denotes H or F, R 2 denotes OH or F, X denotes CH or N, R 3 and R 4 independently of one another denote H, Hal or OA, CHal 3 Hal is F, Cl, Br or I, A denotes H or Alk, Alk is a branched or linear alkyl group having 1 to 8 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, wherein 1 to 7 H-atoms may be independently replaced by Hal, OR, COOR, CN, NR 2, phenyl, linear or branched alkyl having 1, 2 or 3 C atoms, cycloalkyl having 3 to 6 carbon atoms and/or wherein 1 to 3 CH 2 -groups may be replaced by O, -NRCO-, -CO-, -COO-, -CONR, -NR- or S, or cycloalkyl having 3 to 6 carbon atoms, and R is H or is a branched or linear alkyl group having 1 to 8 carbon atoms, as well as the pharmaceutically acceptable salts and N-oxides thereof, in a racemic form or in an enantiomerically pure form or enriched mixture of the respective enantiomers in all ratios, and/or as a mixture of diastereoisomers in all ratios. Y is a group selected from R 1 denotes H or F, R 2 denotes OH or F, X denotes CH or N, R 3 and R 4 independently of one another denote H, Hal or OA, CHal 3 Hal is F, Cl, Br or I, A denotes H or Alk, Alk is a branched or linear alkyl group having 1 to 8 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, wherein 1 to 7 H-atoms may be independently replaced by Hal, OR, COOR, CN, NR 2, phenyl, linear or branched alkyl having 1, 2 or 3 C atoms, cycloalkyl having 3 to 6 carbon atoms and/or wherein 1 to 3 CH 2 -groups may be replaced by O, -NRCO-, -CO-, -COO-, -CONR, -NR- or S, or cycloalkyl having 3 to 6 carbon atoms, and R is H or is a branched or linear alkyl group having 1 to 8 carbon atoms, as well as the pharmaceutically acceptable salts and N-oxides thereof, in a racemic form or in an enantiomerically pure form or enriched mixture of the respective enantiomers in all ratios, and/or as a mixture of diastereoisomers in all ratios.
A polyoxyalkylene ester composition comprising the reaction product of a polyoxyalkylene alcohol or polyol reactant and a monocarboxylic acid acyl donor, wherein the polyoxyalkylene ester composition comprises greater than 90 weight percent of a fully acylated polyoxyalkylene ester, less than 10 weight percent of a partially acylated polyoxyalkylene ester, and 5 parts per million or less of 1,4-dioxane, and having an acid number of 30 or less, in each case based on the weight of the composition, wherein the reaction product is obtainable by a process including the steps of: in a reaction zone, contacting a reaction mixture of the polyoxyalkylated alcohol or polyol reactant and the monocarboxylic acid acyl donor in the presence of immobilized Candida antartica lipase B enzyme catalyst at temperatures of from 40 °C to 80 °C to obtain said composition in said reaction zone, wherein said enzyme catalyst has a concentration of 3 weight % to 8 weight %, based on the total weight of the reactants; and recovering said polyoxyalkylene ester composition.
A tube radiator for heating, comprising a pair of rails, provided with respective pluralities of holes axially spaced apart from one another along the rails and having respective front inlet openings on an outer surface of a rail; and a plurality of tubes positioned between the rails and joined to the rails at respective axial ends of the tubes, inserted in respective holes; the ends of the tubes being fastened to the rails via respective mechanical interference couplings; each hole comprising an outer portion, adjacent to the opening and defining a seat; and an inner portion, adjacent to a longitudinal internal chamber of the rail; each coupling being formed by a coupling portion, positioned at one end of the tube; and by a seat; wherein the coupling portion is inserted with radial interference in the seat, and the coupling portion and the seat are in contact with each other on respective annular surfaces extending axially along an axis of the tube and both substantially cylindrical about the axis; and in that each coupling is also sealed in a fluid-tight manner and each end is permanently fastened in the respective seat; wherein each coupling portion comprises a substantially cylindrical interference zone; and the outer portion and the inner portion of each hole are substantially cylindrical and parallel to the axis, have different diameters, and are joined by an annular shoulder facing towards the opening and substantially perpendicular to the axis; the coupling portion and the seat being in contact through said interference zone and said outer portion, both substantially cylindrical, the interference zone having a diameter such as to be inserted with radial interference in the seat, so as to join the tube to the rail by mechanical interference; characterized in that each coupling portion is at least partly tapered towards the end of the tube, wherein each coupling portion comprises a tapered zone starting from a free end front edge thereof, converging towards the free end front edge of the coupling portion, and wherein the holes are made through a solid base portion of a lateral wall of each rail, between opposite surfaces (11, 12) of the base portion, and for the thickness of the base portion of the lateral wall; and wherein each end of the tubes is permanently fastened in the respective seat by means of an adhesive layer, placed around the coupling portion to form a continuous annular sealing element; or by means of a bead of material of the tube and/or the rail, said bead being positioned around a peripheral edge of the opening and firmly joining the tube to the rail in a fluid-tight manner.
A gas phase polymerization process for producing polyethylene polymers comprising contacting ethylene and at least one C 3 to Cs alpha-olefin comonomer with a polymerization catalyst on a particulate support in a fluidized bed polymerization reactor under conditions effective to polymerize at least part of the ethylene and comonomer, producing and recovering the polyethylene polymers, wherein the fluidized bed comprises growing polymer particles, formed polymer particles, and catalyst particles; wherein the fluidized bed is fluidized by a continuous flow of polymerizable and modifying gaseous components comprising make-up feed and recycle gas passing through the reaction zone at a mass flow rate sufficient to maintain a fluidized bed in the reaction zone, wherein the particulate support has a d 10 particle size as measured by laser diffraction of at least 18 microns, a d 50 particle size as measured by laser diffraction of at least 40 microns, and a d 90 particle size as measured by laser diffraction of no more than 100 microns, and wherein the polyethylene polymers have a density less than 0.940 g/cc.
A safety catheter device comprising a catheter hub and a catheter tube extending therefrom; a needle having a needle shaft terminating in a sharp tip; and a rigid canted-plate clip having a first wall with an aperture adapted to slidably receive the needle shaft therethrough in a first state of the clip, the clip having a second state in which the needle shaft is gripped by the first wall aperture, the clip having a second wall with a portion adapted to bear against the shaft in the first state and being adapted to confront the tip of the needle in the second state, and a strut (24, 26) connecting the first and second walls (16, 20); and a spring member biasing the clip towards the second state; the needle having a first position slidably received through the aperture of the clip first wall, in bearing relationship with the clip second wall portion, and extending through the catheter tube with the sharp tip exposed in the first state of the clip, the needle having a second position in which the needle tip has been pulled out of the catheter tube past the clip second wall so that in the needle second position the clip moves towards the second state and grips the needle shaft with the tip blocked by the clip second wall; the device being characterised in that the strut (24, 26) extends from the first wall of the clip at an included angle of less than 90 degrees relative to the first wall.
A compound capable of inducing exon 50 of the dystrophin gene to skip, which is (a) an oligonucleotide consisting of the nucleotide sequence as shown in any one of SEQ ID NOs 41, 40, 42, 43, 46, 44 and 45, wherein at least one of the sugars constituting the oligonucleotide is modified, and wherein said sugar is D-ribofuranose and at least one modification of said sugar is 2'-O,4'-C-alkylenation of the D-ribofuranose, or (b) a compound represented by the general formula (IV") or (V") or a pharmaocologically acceptable salt thereof, wherein said general formulae are defined as follows: B T"4 -B M"4 -B B"4 (IV") where B T"4 is a group represented by any one of the following (4a") to (4j"): (4a")HO-, (4b")HO-Ba-, (4c")HO-Bc-Ba-, (4d")HO-Bt-Bc-Ba-, (4e")HO-Bg-Bt-Bc-Ba-, HO-Bg-Bg-Bt-Bc-Ba-, (4g")HO-Ba-Bg-Bg-Bt-Bc-Ba-, (4h")HO-Bt-Ba-Bg-Bg-Bt-Bc-Ba-, (4i")HO-Bc-Bt-Ba-Bg-Bg-Bt-Bc-Ba-, or (4j")HO-Bg-Bc-Bt-Ba-Bg-Bg-Bt-Bc-Ba- B M"4 is a group represented by the following formula (4"): -Bg-Bg-Bc-Bt-Bg-Bc-Bt-Bt-Bt- (4") B B"4 is a group represented by any one of the following (104a") to (104j"): (104a")-CH 2 CH 2 OH, (104b")-Bg-CH 2 CH 2 OH, (104c")-Bg-Bc-CH 2 CH 2 OH, (104d")-Bg-Bc-Bc-CH 2 CH 2 OH, (104e")-Bg-Bc-Bc-Bc-CH 2 CH 2 OH, -Bg-Bc-Bc-Bc-Bt-CH 2 CH 2 OH, (104g")-Bg-Bc-Bc-Bc-Bt-Bc-CH 2 CH 2 OH, (104h")-Bg-Bc-Bc-Bc-Bt-Bc-Ba-CH 2 CH 2 OH, (104i")-Bg-Bc-Bc-Bc-Bt-Bc-Ba-Bg-CH 2 CH 2 OH, or (104j")-Bg-Bc-Bc-Bc-Bt-Bc-Ba-Bg-Bc-CH 2 CH 2 OH where Bg is a group represented by the following formula or; Ba is a group represented by the following formula or; Bc is a group represented by the following formula or; and Bt is a group represented by the following formula or: where X is individually and independently a group represented by the following formula or: Y is individually and independently a hydrogen atom, a hydroxyl group or an alkoxy group with 1-6 carbon atoms; and Z is individually and independently a single bond or an alkylene group with 1-5 carbon atoms; provided that at least one of the nucleosides constituting the compound represented by formula (IV") has 2'-O,4'-C-alkylene group; B T"5 -B M"5 -B B"5 (V") where B T"5 is a group represented by any one of the following (5a") to (5j"): (5a")HO-, (5b")HO-Ba-, (5c")HO-Bg-Ba-, (5d")HO-Bg-Bg-Ba-, (5e")HO-Ba-Bg-Bg-Ba-, HO-Bc-Ba-Bg-Bg-Ba-, (5g")HO-Bc-Bc-Ba-Bg-Bg-Ba-, (5h")HO-Bt-Bc-Bc-Ba-Bg-Bg-Ba-, (Si")HO-Bg-Bt-Bc-Bc-Ba-Bg-Bg-Ba-, or (5j")HO-Ba-Bg-Bt-Bc-Bc-Ba-Bg-Bg-Ba- B M"5 is a group represented by the following formula (5"): -Bg-Bc-Bt-Ba-Bg-Bg-Bt-Bc-Ba- (5") B B"5 is a group represented by any one of the following (105a") to (105j"): (105a")-CH 2 CH 2 OH, (105b")-Bg-CH 2 CH 2 OH, (105c")-Bg-Bg-CH 2 CH 2 OH, (105d")-Bg-Bg-Bc-CH 2 CH 2 OH, (105e")-Bg-Bg-Bc-Bt-CH 2 CH 2 OH, -Bg-Bg-Bc-Bt-Bg-CH 2 CH 2 OH, (105g")-Bg-Bg-Bc-Bt-Bg-Bc-CH 2 CH 2 OH, (105h")-Bg-Bg-Bc-Bt-Bg-Bc-Bt-CH 2 CH 2 OH, (105i")-Bg-Bg-Bc-Bt-Bg-Bc-Bt-Bt-CH 2)CH 2)OH, or (105j")-Bg-Bg-Bc-Bt-Bg-Bc-Bt-Bt-Bt-CH 2 CH 2 OH where Bg, Ba, Bt and Bc are as defined above; provided that at least one of the nucleosides constituting the compound represented by formula (V") has 2'-O,4'-C-alkylene group;
A Positron Emission Tomography device including detection means located so as to surround a subject to detect radiation emitted by said subject; and driving means driving said detection means, wherein said detection means includes detection heads of a first group, arranged in the circumferential direction thereof and detection heads of a second group each disposed between said detection heads of the first group, said detection heads of the first group can be moved along the radial direction of said detection means by way of said driving means, said detection heads of the second group can be moved along the radial direction of said detection means by way of said driving means, said detection heads of the second group move together with said detection heads of the first group to increase the solid angle coverage ratio of said detection means, an operation mode of the PET device is convertible from a first mode to a second mode, the detection means having first diameter (D Body) in the first mode and having second diameter (D Head) in the second mode, when the operation mode of the PET device is converted from the first mode to the second mode, the detection heads of the first group and the detection heads of the second group move linearly along the inner radial direction of said detection means, in the first mode, the detection heads of the first group and the detection heads of the second group are disposed in a circumference of the first diameter (D Body), and the detection heads of the second group are disposed respectively between the detection heads of the first group, when converting in the second mode, the detection heads of the first group are moved to the inside of the radial direction such that they are disposed in a circumference of the second diameter (D Head) for firstly absorbing the radiation photons emitted from the subject, and the detection heads of the second group are moved with an identical distance to the inside of the radial direction until the upper sides thereof reach the detection heads of the first group or until the upper sides thereof surround the detection heads of the first group at a set interval, such that the detection heads of the second group are disposed to surround the detection heads of the first group and to cover the gaps between the detection heads of the first group for secondly absorbing the radiation photons passing through the gaps.
A system for transmitting at least one electric pulse for an apparatus for determining a distribution of charges contained in the thickness of an item made of dielectric material, said transmission system including a transmitter electrode (1, 42) for transmitting at least one pulse and a generator of said pulse, characterized in that said electrode is formed by a transmission line which is substantially level in relation to the item to be analyzed and which includes impedance matching means to keep said impedance substantially constant along said transmission line in the passband of said pulse; and in that said impedance matching means (12, 13, 14, 18, 19, 20) include electric link means (18, 19) between, on the one hand, the pulse generator and one end of the transmitter electrode (1, 42), and, on the other hand, between a second end of the transmitter electrode and a load, the impedance of which is equal to the characteristic impedance of the electrode.
Holding arrangement for a vehicle with a steering column, the holding arrangement comprising an instrument panel and display means, wherein the holding arrangement is connected to the instrument panel, the holding arrangement having a support device arranged above the steering column, characterized in that at least one hook which is arranged open towards the steering column is attached to the display means and wherein the support device has a bearing element which is partly arranged in the hook to form a connection with the display means, so that the bearing element can be pivoted about a pivot axis together with the display means, wherein the bearing element is connected to the instrument panel by the shaft, which is attached to the instrument panel, and further attached to the display by the hook and wherein the display means is detachable connected with the bearing element, and wherein, in the event of an accident-related application of force below the threshold value, the bearing element together with the display means is initially rotatable in the direction of the instrument panel about the pivot axis to form a housing, so that the steering column, which is pushed in the direction of the display means, is movable in the housing, in order to avoid or at least reduce the risk of destruction of the display means. at least one hook which is arranged open towards the steering column is attached to the display means and wherein the support device has a bearing element which is partly arranged in the hook to form a connection with the display means, so that the bearing element can be pivoted about a pivot axis together with the display means, wherein the bearing element is connected to the instrument panel by the shaft, which is attached to the instrument panel, and further attached to the display by the hook and wherein the display means is detachable connected with the bearing element, and wherein, in the event of an accident-related application of force below the threshold value, the bearing element together with the display means is initially rotatable in the direction of the instrument panel about the pivot axis to form a housing, so that the steering column, which is pushed in the direction of the display means, is movable in the housing, in order to avoid or at least reduce the risk of destruction of the display means.
A localized user environment on system for providing an oxygen enriched an aircraft having a passenger cabin comprising: a gas separation system having an oxygen output channel for outputting a flow of oxygen enriched air, wherein the gas separation system is a nitrogen generation system; and a partially, or fully, enclosed user compartment for a selected passenger, the user compartment having a user support device and an oxygen enriched air dispenser, and wherein the user compartment includes a user-operable control for regulating the flow of oxygen enriched air; and a duct network coupled to the oxygen output channel and comprising a manifold, the duct network being configured to direct the flow of oxygen enriched air through the manifold to the dispenser, which dispenser is configured to receive and dispense the flow of oxygen enriched air to a localized volume in the user compartment thereby increasing the partial pressure of oxygen in the user compartment. a gas separation system having an oxygen output channel for outputting a flow of oxygen enriched air, wherein the gas separation system is a nitrogen generation system; and a partially, or fully, enclosed user compartment for a selected passenger, the user compartment having a user support device and an oxygen enriched air dispenser, and wherein the user compartment includes a user-operable control for regulating the flow of oxygen enriched air; and a duct network coupled to the oxygen output channel and comprising a manifold, the duct network being configured to direct the flow of oxygen enriched air through the manifold to the dispenser, which dispenser is configured to receive and dispense the flow of oxygen enriched air to a localized volume in the user compartment thereby increasing the partial pressure of oxygen in the user compartment.
Method for manufacturing of a paper, board or tissue, the method comprising - obtaining a stock comprising cellulosic fibers, - adding to the stock a strength additive system comprising - a cationic strength agent, which is a cationic polymer with aldehyde functional groups, which has a charge density of 0.1 - 5.5 meq/g, and - an anionic copolymer obtained by polymerization of a reaction mixture comprising (meth)acrylamide and anionic monomers, the standard viscosity of the obtained copolymer being in the range of 1.8 - 3.0 mPas. - obtaining a stock comprising cellulosic fibers, - adding to the stock a strength additive system comprising - a cationic strength agent, which is a cationic polymer with aldehyde functional groups, which has a charge density of 0.1 - 5.5 meq/g, and - an anionic copolymer obtained by polymerization of a reaction mixture comprising (meth)acrylamide and anionic monomers, the standard viscosity of the obtained copolymer being in the range of 1.8 - 3.0 mPas. - a cationic strength agent, which is a cationic polymer with aldehyde functional groups, which has a charge density of 0.1 - 5.5 meq/g, and - an anionic copolymer obtained by polymerization of a reaction mixture comprising (meth)acrylamide and anionic monomers, the standard viscosity of the obtained copolymer being in the range of 1.8 - 3.0 mPas.
A millimeter wave bands semiconductor device comprising: a first metal block including a first penetration hole and a second penetration hole; a second metal block including a first non-penetration hole and a second non-penetration hole; and a circuit board that is disposed between the first metal block and the second metal block and that has an input signal line and an output signal line on a front side surface thereof, wherein the first metal block and the second metal block are disposed such that the first non-penetration hole and the first penetration hole constitute a first waveguide and the second non-penetration hole and the second penetration hole constitute a second waveguide, characterised in that the first waveguide has a flattening film (26a, 35a) which contains Ag nanoparticles on an inner surface thereof, and the second waveguide has a flattening film (27a, 36a) which contains Ag nanoparticles on an inner surface thereof. a first metal block including a first penetration hole and a second penetration hole; a second metal block including a first non-penetration hole and a second non-penetration hole; and a circuit board that is disposed between the first metal block and the second metal block and that has an input signal line and an output signal line on a front side surface thereof, wherein the first metal block and the second metal block are disposed such that the first non-penetration hole and the first penetration hole constitute a first waveguide and the second non-penetration hole and the second penetration hole constitute a second waveguide,
A molten metal handling device, comprising: an outer casing with a bottom and two side walls generally defining an inner cavity; one or more heater assemblies (107, 180, 200, 210, 220) within the outer casing, each heater assembly (107, 180, 200, 210, 220) comprising: a heater assembly body (112, 181, 201, 211, 221) with an inward facing surface, the inward facing surface including recesses; heater coils (108, 183, 202) within the heater assembly body spaced apart from the inward facing surface of the heater assembly body; a castable refractory body abutting the one or more heater assemblies, the castable refractory body defining a molten metal carrying cavity with a bottom wall, a first side wall and a second side wall; and wherein thermal inducing cement is disposed within the recesses in the inward facing surface of the heater assembly body, facilitating conductive heat transfer from the heater coils (108, 183, 203) through the thermal inducing cement (110, 213, 223) to the refractory body. an outer casing with a bottom and two side walls generally defining an inner cavity; one or more heater assemblies (107, 180, 200, 210, 220) within the outer casing, each heater assembly (107, 180, 200, 210, 220) comprising: a heater assembly body (112, 181, 201, 211, 221) with an inward facing surface, the inward facing surface including recesses; heater coils (108, 183, 202) within the heater assembly body spaced apart from the inward facing surface of the heater assembly body; a heater assembly body (112, 181, 201, 211, 221) with an inward facing surface, the inward facing surface including recesses; heater coils (108, 183, 202) within the heater assembly body spaced apart from the inward facing surface of the heater assembly body; a castable refractory body abutting the one or more heater assemblies, the castable refractory body defining a molten metal carrying cavity with a bottom wall, a first side wall and a second side wall; and