mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for identifying microRNAs, or their target mRNAs, the expression of which, during infection of cells by a virus using a cell receptor and at least one cell co-receptor for entering the cell, is specifically modified according to the cell co-receptor used by the virus for its entry into the cells, comprising: i) determining the expression levels of microRNAs in a test cell, expressing a receptor, a first co-receptor and at least one other co-receptor, after infection by a first virus using the first co-receptor and by at least one other virus using another co-receptor, respectively; ii) identifying the microRNAs, the expression level of which is modulated during the infection by each of the viruses relatively to the expression level in uninfected cells; iii) comparing the thus-identified microRNAs; iv) selecting the microRNAs, the modification of the expression level of which is specific to the use of a co-receptor; v) optionally identifying the target mRNAs of the thereby selected microRNAs. i) determining the expression levels of microRNAs in a test cell, expressing a receptor, a first co-receptor and at least one other co-receptor, after infection by a first virus using the first co-receptor and by at least one other virus using another co-receptor, respectively; ii) identifying the microRNAs, the expression level of which is modulated during the infection by each of the viruses relatively to the expression level in uninfected cells; iii) comparing the thus-identified microRNAs; iv) selecting the microRNAs, the modification of the expression level of which is specific to the use of a co-receptor; v) optionally identifying the target mRNAs of the thereby selected microRNAs.
A flexible needle comprising: a flexible elongate needle body with a needle lumen extending therein, the elongate needle body including a distal region configured to pierce or puncture target tissue; a shape sensor coupled to the elongate needle body; and a connector adapted for connecting the shape sensor to a processor for determining the shape of the elongate flexible needle body based on data from the shape sensor. a flexible elongate needle body with a needle lumen extending therein, the elongate needle body including a distal region configured to pierce or puncture target tissue; a shape sensor coupled to the elongate needle body; and a connector adapted for connecting the shape sensor to a processor for determining the shape of the elongate flexible needle body based on data from the shape sensor.
Pressure amplifier comprising a housing, an amplification piston in the housing having a high pressure area in a high pressure chamber and a low pressure area in a low pressure chamber, and a switching valve having a pressure controlled valve element having a large pressure area and a small pressure area, characterized in that the valve element and the amplification piston are located in a same bore (3, 4) in the housing, wherein the valve element is located in the part of the bore forming the low pressure chamber, wherein the low pressure chamber has an inner diameter corresponding to an outer diameter of a front part of the valve element.
Method for packaging of a product, comprising: - feeding in a film of packaging material, - applying a plurality of labels (26; 93) to the film of packaging material such that each label is stuck to the film with the aid of an adhesive, such as a glue, and such that a part (96, 97) of each label (26; 93) is adhesive-free and can be gripped by a user, - forming openings (94; 106; 107) in the film of packaging material at the places of the labels (26; 93) such that each label (26; 93) entirely covers up one opening (94; 106; 107) and the plurality of labels (26; 93) only partly cover said film, and - packaging at least one product in this packaging material, characterized in that the packaging material is a shrink film having a thickness of between 5 and 35 μm, and the method is performed such that: - said applying of said labels is performed prior to said forming of said openings, - said forming of said openings is performed without forming a corresponding opening in the label (26; 93) that lies beyond it, - said packaging comprises in-line packaging by shrinking said shrink film over said at least one product. - feeding in a film of packaging material, - applying a plurality of labels (26; 93) to the film of packaging material such that each label is stuck to the film with the aid of an adhesive, such as a glue, and such that a part (96, 97) of each label (26; 93) is adhesive-free and can be gripped by a user, - forming openings (94; 106; 107) in the film of packaging material at the places of the labels (26; 93) such that each label (26; 93) entirely covers up one opening (94; 106; 107) and the plurality of labels (26; 93) only partly cover said film, and - packaging at least one product in this packaging material, - said applying of said labels is performed prior to said forming of said openings, - said forming of said openings is performed without forming a corresponding opening in the label (26; 93) that lies beyond it, - said packaging comprises in-line packaging by shrinking said shrink film over said at least one product.
A combination phase plug, comprising: a first phase plug, comprising: a cone; a plurality of first fins, located on an outer surface of the cone; and a plurality of second fins, located on the outer surface of the cone, wherein the first fins and the second fins are arranged staggeredly, and a first gap is provided between any adjacent first fin and second fin; and a second phase plug, located under the first phase plug, and comprising: a round-disc base; a combining portion, located in the center of the round-disc base, wherein the combining portion and the cone may be combined with each other; and a plurality of second gaps, located between an outer edge of the round-disc base and the combining portion, wherein the first gaps are respectively aligned with the second gaps. a first phase plug, comprising: a cone; a plurality of first fins, located on an outer surface of the cone; and a plurality of second fins, located on the outer surface of the cone, wherein the first fins and the second fins are arranged staggeredly, and a first gap is provided between any adjacent first fin and second fin; and a cone; a plurality of first fins, located on an outer surface of the cone; and a plurality of second fins, located on the outer surface of the cone, wherein the first fins and the second fins are arranged staggeredly, and a first gap is provided between any adjacent first fin and second fin; and a second phase plug, located under the first phase plug, and comprising: a round-disc base; a combining portion, located in the center of the round-disc base, wherein the combining portion and the cone may be combined with each other; and a plurality of second gaps, located between an outer edge of the round-disc base and the combining portion, wherein a round-disc base; a combining portion, located in the center of the round-disc base, wherein the combining portion and the cone may be combined with each other; and a plurality of second gaps, located between an outer edge of the round-disc base and the combining portion, wherein the first gaps are respectively aligned with the second gaps.
An apparatus (100, 200) for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient comprising: a) a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes; b) structural means incorporating an inanimate source of energy operatively connected to said plurality of electrodes for deploying said electrodes without significant distortion, and wherein said source of energy is sufficient to impart a force of at least 0.7 kg/square millimeter (1000 pounds per square inch) of total cross sectional area of all electrodes at the initiation of the deployment of said electrodes, and a force of at least 0.35 kg/square millimeter (500 pounds per square inch) of total cross-sectional area of the electrodes at the end of the deployment of said electrodes such that the electrodes are deployed without substantial distortion within the tissue of a patient; and c) means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state. a) a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes; b) structural means incorporating an inanimate source of energy operatively connected to said plurality of electrodes for deploying said electrodes without significant distortion, and wherein said source of energy is sufficient to impart a force of at least 0.7 kg/square millimeter (1000 pounds per square inch) of total cross sectional area of all electrodes at the initiation of the deployment of said electrodes, and a force of at least 0.35 kg/square millimeter (500 pounds per square inch) of total cross-sectional area of the electrodes at the end of the deployment of said electrodes such that the electrodes are deployed without substantial distortion within the tissue of a patient; and c) means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.
A brazing material for bonding between a ceramic substrate and a metal plate, the brazing material being a powder mixture provided by mixing an alloy powder consisting of 55 to 80 mass% of Ag, 1 to 5 mass% of In, optionally 0.1 mass% or under of oxygen content, optionally 0.0001 to 0.5 mass% of Si, and the balance Cu with inevitable impurities, and an Ag powder, containing an active metal selected from Ti, Zr, or Hf, characterized in that; an active metal hydride powder composed of a hydride of the active metal is mixed with said powder mixture, a composition ratio of Ag to the total amount of Ag and Cu contained in said powder mixture, Ag/(Ag + Cu), being 0.57 to 0.85, the brazing material containing said active metal hydride powder with an equivalent circle average diameter of particles of 10 to 25 μ m by 0.27 to 5.17 mass%, the equivalent circle average diameters of particles for said alloy powder, said Ag powder, and said active metal hydride powder meeting a relationship of alloy powder ≥ active metal hydride powder > Ag powder, and in the cumulative distribution in volume base given upon a measurement of the particle size distribution in conformity with JIS Z 8825-1, said powder mixture having a particle size distribution of a cumulative 10% particle diameter of 3 to 10 μ m, a cumulative 50% particle diameter of 10 to 35 μ m, and a cumulative 90% particle diameter of 29.4 to 50 μ m, and in the frequency distribution, a peak existing between the cumulative 50% particle diameter and the cumulative 90% particle diameter.
Method of inspecting an integrated circuit having a semiconductor substrate and a circuit portion formed on a front face side of the semiconductor substrate, the method including providing an apparatus comprising: a light generation unit for generating light for irradiating the integrated circuit; a wavelength width adjustment unit (5, 14) for adjusting a wavelength width, d, of the light for irradiating the integrated circuit; an irradiation position adjustment unit for adjusting an irradiation position of the light for irradiating the integrated circuit; and a light detection unit for detecting light from the integrated circuit when the light from the light generation unit irradiates the circuit portion through a rear face of the semiconductor substrate; characterised in that the light generation unit has a superluminescent diode; and in that the method further comprises adjusting the wavelength width d by means of the wavelength width adjustment unit (5, 14) by regulating a voltage applied to the superluminescent diode to satisfy d < 7 λ 2 / Tn, and 2 ⁢ tn < 0.441 λ 2 / d wherein λ is the center wavelength of the light, T is the thickness of the semiconductor substrate, n is the refractive index of the semiconductor substrate, and t is a depth of a depletion layer near the circuit portion. a light generation unit for generating light for irradiating the integrated circuit; a wavelength width adjustment unit (5, 14) for adjusting a wavelength width, d, of the light for irradiating the integrated circuit; an irradiation position adjustment unit for adjusting an irradiation position of the light for irradiating the integrated circuit; and a light detection unit for detecting light from the integrated circuit when the light from the light generation unit irradiates the circuit portion through a rear face of the semiconductor substrate; characterised in that the light generation unit has a superluminescent diode; and in that the method further comprises adjusting the wavelength width d by means of the wavelength width adjustment unit (5, 14) by regulating a voltage applied to the superluminescent diode to satisfy wherein λ is the center wavelength of the light, T is the thickness of the semiconductor substrate, n is the refractive index of the semiconductor substrate, and t is a depth of a depletion layer near the circuit portion.
Use of lithium silicate glass ceramic which comprises trivalent metal oxide selected from Y 2 O 3, La 2 O 3, Yb 2 O 3, Bi 2 O 3 and mixtures thereof, wherein the glass ceramic is substantially free from K 2 O and Na 2 O, as dental material.
A method for providing a virtual base station in a mobile network, wherein the mobile network comprising one or more virtual base stations, 'VBS', wherein a VBS comprises at least one radio access point, 'RAP' and a set of virtual radio access functions, 'VRAF', said set of VRAFs forming a virtual radio access point 'VRAP', wherein the VBS is configured by providing a description of radio access functionalities, which are executed by the RAP and by the VRAFs and wherein the VBS is executed jointly at the location of said at least one RAP and on a cloud computing platform by the VRAFs, wherein said VBS forming a logical functional network entity, and wherein the VRAFs being executed on said cloud computing platform and wherein said VBS providing a service and a radio access technology and wherein said description is dependent on at least one of service, radio access technology, a location of the RAP and/or a configuration of an operator of the mobile network and wherein a self-test of the VBS including a connectivity test is performed prior to its regular operation by sending an initial setup message from the RAP to the VRAP or vice versa.
A controller for an electrical generator comprising: one or more filter components configured to receive a power grid frequency signal and to output the frequency signal when the frequency signal is outside a frequency band; one or more a frequency response schedule components configured to determine an ultimate target power contribution based at least partly on the filtered frequency signal, wherein the ultimate target power contribution represents an ultimate amount of power contribution that the electrical generator should provide in a primary frequency response; and one or more flexible rate limiter components configured to determine and provide an immediate target power contribution signal that varies over time and approaches the ultimate target power contribution based at least in part on a rate-limiting schedule, wherein the immediate target power contribution signal is configured to cause the electrical generator to increase or decrease a power output by the electrical generator by an amount corresponding to the immediate target power contribution signal; characterized in that the flexible rate-limiting schedule comprises a rate table that correlates the immediate target power contribution signal, the ultimate target power contribution and time since a change in the frequency signal to be outside the frequency band, wherein each frequency response schedule component or the rate limiter component, or both, are configured such that the immediate target power contribution signal causes the electrical generator to simulate another generator of the power grid. one or more filter components configured to receive a power grid frequency signal and to output the frequency signal when the frequency signal is outside a frequency band; one or more a frequency response schedule components configured to determine an ultimate target power contribution based at least partly on the filtered frequency signal, wherein the ultimate target power contribution represents an ultimate amount of power contribution that the electrical generator should provide in a primary frequency response; and one or more flexible rate limiter components configured to determine and provide an immediate target power contribution signal that varies over time and approaches the ultimate target power contribution based at least in part on a rate-limiting schedule, wherein the immediate target power contribution signal is configured to cause the electrical generator to increase or decrease a power output by the electrical generator by an amount corresponding to the immediate target power contribution signal; characterized in that the flexible rate-limiting schedule comprises a rate table that correlates the immediate target power contribution signal, the ultimate target power contribution and time since a change in the frequency signal to be outside the frequency band, wherein each frequency response schedule component or the rate limiter component, or both, are configured such that the immediate target power contribution signal causes the electrical generator to simulate another generator of the power grid.
A method for reliably determining a state variable of a polyphase synchronous machine that is supplied with electric current by a polyphase power network with n phases (U,...,N), where n≥3, wherein current values of at least n-1 phase currents (I u,...,I n-1) from at least n-1 phases (U,...,N-1) of the polyphase power network are detected and the state variable is determined by means of the at least n-1 instantaneous current values (I u,...,I n-1), wherein current values of all n phase currents (I u,...,I n) from the n-phase polyphase power network are detected and the n phase currents (I u,...,I n) are correlated with one another and the result of the correlation of all n phase currents (I u,...,I n) is used for a plausibility check of the n-1 phase currents (I u,...,I n-1) used for determining the state variable, wherein a current space vector is determined with the at least n-1 phase currents (I u,...,I n-1), characterized in that without the use of the rotation angle (φ) it is assumed that the current space vector corresponds to a maximum torque-generating current component (i q,max) and in that the state variable of the polyphase synchronous machine is determined with the maximum torque-generating current component (i q,max).
A water-based ink for an inkjet comprising a pigment, a fixing resin, an organic solvent and water, wherein the fixing resin comprises an A-B block polymer having an A block and a B block, the A block contains a structural unit (P-1) having an anionic functional group, the A block and the B block are each, independently, a block containing one type of polymer selected from among a styrene-based polymer, a (meth)acrylic-based polymer and a styrene-(meth)acrylic-based polymer, an amount of structural units contained in the A block is 5 to 25 mol% of a total molar amount of structural units contained in the A-B block polymer, an amount of the structural unit (P-1) having an anionic functional group contained in the A block is at least 85 mol% of a total molar amount of the structural unit (P-1) having an anionic functional group contained in the A-B block polymer, and the acid value of the A-B block polymer is from 5 to 80 mgKOH/g. the fixing resin comprises an A-B block polymer having an A block and a B block, the A block contains a structural unit (P-1) having an anionic functional group, the A block and the B block are each, independently, a block containing one type of polymer selected from among a styrene-based polymer, a (meth)acrylic-based polymer and a styrene-(meth)acrylic-based polymer, an amount of structural units contained in the A block is 5 to 25 mol% of a total molar amount of structural units contained in the A-B block polymer, an amount of the structural unit (P-1) having an anionic functional group contained in the A block is at least 85 mol% of a total molar amount of the structural unit (P-1) having an anionic functional group contained in the A-B block polymer, and the acid value of the A-B block polymer is from 5 to 80 mgKOH/g.
A method of making nanostructured polymeric film comprising: providing a tool having a porous anodized aluminum surface or a metallic replica thereof, wherein the average depth of the pores is in a range of from 0.1 micrometer to 5 micrometers and the average pore width is in a range of from 10 to 500 nanometers; forming a continuous layer of thermoplastic polymer on at least a portion of the surface of the tool such that the continuous layer extends into the pores of the surface, wherein the thermoplastic polymer is selected from cellulose esters, poly alpha-olefins, and combinations thereof; and separating the continuous layer from the tool as a film having first and second opposed major surfaces with nanofibrils formed on the first major surface, the nanofibrils have an average width of from 5 to 200 nm and an aspect ratio of at least 10, wherein the continuous layer comprises a fluorocarbon melt additive. providing a tool having a porous anodized aluminum surface or a metallic replica thereof, wherein the average depth of the pores is in a range of from 0.1 micrometer to 5 micrometers and the average pore width is in a range of from 10 to 500 nanometers; forming a continuous layer of thermoplastic polymer on at least a portion of the surface of the tool such that the continuous layer extends into the pores of the surface, wherein the thermoplastic polymer is selected from cellulose esters, poly alpha-olefins, and combinations thereof; and separating the continuous layer from the tool as a film having first and second opposed major surfaces with nanofibrils formed on the first major surface, the nanofibrils have an average width of from 5 to 200 nm and an aspect ratio of at least 10,