A topical vitamin D and UBIQUINOL oral supplement composition useful in treating oral inflammation and oxidative stress, comprising: a saliva soluble, aqueous-free emulsion carrier comprised of polydimethylsiloxane emulsified in a nonionic surfactant that is capable of forming a mucoadhesive gel in the presence of saliva; effective levels of vitamin D and UBIQUINOL supplements; a stabilizing composition for UBIQUINOL supplement; a trans-oral mucosal absorption facilitator; and spilanthes extract, wherein: upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said vitamin D and UBIQUINOL supplement mixture, said stabilizer composition for UBIQUINOL supplement, said trans-oral mucosal absorption facilitator and said spilanthes extract onto said oral mucosa; and upon contacting said oral mucosa, said vitamin D and UBIQUINOL supplement mixture, spilanthes extract and trans-oral mucosal absorption facilitators passively diffuse through said oral mucosa: (a) regulating the in vivo availability and immune response of vitamin D and UBIQUINOL supplements; (b) restoring and maintaining adequate levels of circulating vitamin D and UBIQUINOL; (c) minimizing risk of hypercalcemia; while (d) treating oral inflammation and oxidative stress. a saliva soluble, aqueous-free emulsion carrier comprised of polydimethylsiloxane emulsified in a nonionic surfactant that is capable of forming a mucoadhesive gel in the presence of saliva; effective levels of vitamin D and UBIQUINOL supplements; a stabilizing composition for UBIQUINOL supplement; a trans-oral mucosal absorption facilitator; and spilanthes extract, wherein: upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said vitamin D and UBIQUINOL supplement mixture, said stabilizer composition for UBIQUINOL supplement, said trans-oral mucosal absorption facilitator and said spilanthes extract onto said oral mucosa; and upon contacting said oral mucosa, said vitamin D and UBIQUINOL supplement mixture, spilanthes extract and trans-oral mucosal absorption facilitators passively diffuse through said oral mucosa: (a) regulating the in vivo availability and immune response of vitamin D and UBIQUINOL supplements; (b) restoring and maintaining adequate levels of circulating vitamin D and UBIQUINOL; (c) minimizing risk of hypercalcemia; while (d) treating oral inflammation and oxidative stress. upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said vitamin D and UBIQUINOL supplement mixture, said stabilizer composition for UBIQUINOL supplement, said trans-oral mucosal absorption facilitator and said spilanthes extract onto said oral mucosa; and upon contacting said oral mucosa, said vitamin D and UBIQUINOL supplement mixture, spilanthes extract and trans-oral mucosal absorption facilitators passively diffuse through said oral mucosa: (a) regulating the in vivo availability and immune response of vitamin D and UBIQUINOL supplements; (b) restoring and maintaining adequate levels of circulating vitamin D and UBIQUINOL; (c) minimizing risk of hypercalcemia; while (d) treating oral inflammation and oxidative stress. (a) regulating the in vivo availability and immune response of vitamin D and UBIQUINOL supplements; (b) restoring and maintaining adequate levels of circulating vitamin D and UBIQUINOL; (c) minimizing risk of hypercalcemia; while (d) treating oral inflammation and oxidative stress.