A compound of formula, wherein R 1 is wherein R 4 is cyano or halogen; R 5 is H or halogen; R 2 is C 1-6 alkyl; R 3 is 1,3-dihydropyrrolo[3,4-c]pyridinyl substituted by piperazinyl; 3,4-dihydro-1H-2,7-naphthyridinyl substituted by piperazinyl; 3,4-dihydro-1H-isoquinolinyl substituted by one or two substituents independently selected from hydroxy, piperazinyl and C 1-6 alkylpiperazinyl; 3,4-dihydro-2H-quinolinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-b]pyridinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-d]pyrimidinyl substituted by piperazinyl or C 1-6 alkylpiperazinyl; 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl substituted by C 1-6 alkylpiperazinyl; 7,8-dihydro-SH-1,6-naphthyridinyl substituted by piperazinyl; isoindolinyl substituted by one or two substituents independently selected from ((C 1-6 alkyl) 2 amino)C 1-6 alkoxy; (C 1-6 alkoxyC 1-6 alkyl)piperazinyl; (C 1 - 6 alkyl) 2 piperazinyl; (C 1-6 alkyl) 2 pyridinyl; (hydroxyC 1-6 alkyl)piperazinyl; 1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazinyl; 1,6-diazaspiro[3.3]heptanyl; 2,6-diazaspiro[3.3]heptanyl; 3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazinyl; 3,8-diazabicyclo[3.2.1]octanyl; 3-oxa-7,9-diazabicyclo[3.3.1]nonanyl; 4,7-diazaspiro[2.5]octanyl; aminoazetidinyl; aminoC 1-6 alkylamino; C 1-6 alkoxycarbonylpiperazinyl; C 1-6 alkyl; C 1-6 alkylimidazolyl; C 1-6 alkylpiperazinyl; C 3-7 cycloalkylpiperazinyl; carboxypiperazinyl; haloC 1-6 alkylpiperazinyl; halogen; morpholinylC 1-6 alkyl; oxopiperazinyl; piperazinyl; piperidinyl; piperidinylC 1-6 alkyl; pyrrolidinyl and pyrrolidinyloxy; or -NR 6a R 6b; wherein R 6a is H or C 1-6 alkyl; R 6b is phenylC 1-6 alkyl substituted by piperazinyl; or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. R 1 is wherein R 4 is cyano or halogen; R 5 is H or halogen; R 2 is C 1-6 alkyl; R 3 is 1,3-dihydropyrrolo[3,4-c]pyridinyl substituted by piperazinyl; 3,4-dihydro-1H-2,7-naphthyridinyl substituted by piperazinyl; 3,4-dihydro-1H-isoquinolinyl substituted by one or two substituents independently selected from hydroxy, piperazinyl and C 1-6 alkylpiperazinyl; 3,4-dihydro-2H-quinolinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-b]pyridinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-d]pyrimidinyl substituted by piperazinyl or C 1-6 alkylpiperazinyl; 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl substituted by C 1-6 alkylpiperazinyl; 7,8-dihydro-SH-1,6-naphthyridinyl substituted by piperazinyl; isoindolinyl substituted by one or two substituents independently selected from ((C 1-6 alkyl) 2 amino)C 1-6 alkoxy; (C 1-6 alkoxyC 1-6 alkyl)piperazinyl; (C 1 - 6 alkyl) 2 piperazinyl; (C 1-6 alkyl) 2 pyridinyl; (hydroxyC 1-6 alkyl)piperazinyl; 1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazinyl; 1,6-diazaspiro[3.3]heptanyl; 2,6-diazaspiro[3.3]heptanyl; 3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazinyl; 3,8-diazabicyclo[3.2.1]octanyl; 3-oxa-7,9-diazabicyclo[3.3.1]nonanyl; 4,7-diazaspiro[2.5]octanyl; aminoazetidinyl; aminoC 1-6 alkylamino; C 1-6 alkoxycarbonylpiperazinyl; C 1-6 alkyl; C 1-6 alkylimidazolyl; C 1-6 alkylpiperazinyl; C 3-7 cycloalkylpiperazinyl; carboxypiperazinyl; haloC 1-6 alkylpiperazinyl; halogen; morpholinylC 1-6 alkyl; oxopiperazinyl; piperazinyl; piperidinyl; piperidinylC 1-6 alkyl; pyrrolidinyl and pyrrolidinyloxy; or -NR 6a R 6b; wherein R 6a is H or C 1-6 alkyl; R 6b is phenylC 1-6 alkyl substituted by piperazinyl; 1,3-dihydropyrrolo[3,4-c]pyridinyl substituted by piperazinyl; 3,4-dihydro-1H-2,7-naphthyridinyl substituted by piperazinyl; 3,4-dihydro-1H-isoquinolinyl substituted by one or two substituents independently selected from hydroxy, piperazinyl and C 1-6 alkylpiperazinyl; 3,4-dihydro-2H-quinolinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-b]pyridinyl substituted by piperazinyl; 5,7-dihydropyrrolo[3,4-d]pyrimidinyl substituted by piperazinyl or C 1-6 alkylpiperazinyl; 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl substituted by C 1-6 alkylpiperazinyl; 7,8-dihydro-SH-1,6-naphthyridinyl substituted by piperazinyl; isoindolinyl substituted by one or two substituents independently selected from ((C 1-6 alkyl) 2 amino)C 1-6 alkoxy; (C 1-6 alkoxyC 1-6 alkyl)piperazinyl; (C 1 - 6 alkyl) 2 piperazinyl; (C 1-6 alkyl) 2 pyridinyl; (hydroxyC 1-6 alkyl)piperazinyl; 1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazinyl; 1,6-diazaspiro[3.3]heptanyl; 2,6-diazaspiro[3.3]heptanyl; 3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazinyl; 3,8-diazabicyclo[3.2.1]octanyl; 3-oxa-7,9-diazabicyclo[3.3.1]nonanyl; 4,7-diazaspiro[2.5]octanyl; aminoazetidinyl; aminoC 1-6 alkylamino; C 1-6 alkoxycarbonylpiperazinyl; C 1-6 alkyl; C 1-6 alkylimidazolyl; C 1-6 alkylpiperazinyl; C 3-7 cycloalkylpiperazinyl; carboxypiperazinyl; haloC 1-6 alkylpiperazinyl; halogen; morpholinylC 1-6 alkyl; oxopiperazinyl; piperazinyl; piperidinyl; piperidinylC 1-6 alkyl; pyrrolidinyl and pyrrolidinyloxy; or -NR 6a R 6b; wherein R 6a is H or C 1-6 alkyl; R 6b is phenylC 1-6 alkyl substituted by piperazinyl; R 6a is H or C 1-6 alkyl; R 6b is phenylC 1-6 alkyl substituted by piperazinyl; or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.