A method of comprehensive chromatography analysis comprising: separating a sample in a primary chromatographic column; directing a primary stream exiting the primary chromatographic column toward a non-modulator switching system wherein the non-modulator switching system comprises at least one micro-switch and at least one valve; and continuously operating the non-modulator switching system to selectively direct the primary stream to a plurality of thermal injectors and a plurality of secondary chromatographic columns, wherein each of the plurality of thermal injectors is provided in parallel with one another and is in fluid communication with a respective secondary chromatographic column of the plurality, wherein the continuously operating includes: (a) selectively directing a portion of the primary stream to one of the plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) injecting the portion of the primary stream into one of the plurality of secondary chromatographic columns in fluid communication with the one of the plurality of thermal injectors; (c) detecting one or more target analytes in a secondary stream exiting the one of the plurality of secondary chromatographic columns; and repeating (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors of the plurality of thermal injectors and the plurality of secondary chromatographic columns in fluid communication therewith until substantially all of the target analytes in the sample are detected after exiting the plurality of secondary chromatographic columns to provide a comprehensive analysis of the sample, wherein a separation time in each secondary chromatographic column of the plurality of secondary chromatographic columns is less than or equal to a product of the predetermined amount of time and a quantity of secondary chromatographic columns in the plurality of secondary chromatographic columns. separating a sample in a primary chromatographic column; directing a primary stream exiting the primary chromatographic column toward a non-modulator switching system wherein the non-modulator switching system comprises at least one micro-switch and at least one valve; and continuously operating the non-modulator switching system to selectively direct the primary stream to a plurality of thermal injectors and a plurality of secondary chromatographic columns, wherein each of the plurality of thermal injectors is provided in parallel with one another and is in fluid communication with a respective secondary chromatographic column of the plurality, wherein the continuously operating includes: (a) selectively directing a portion of the primary stream to one of the plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) injecting the portion of the primary stream into one of the plurality of secondary chromatographic columns in fluid communication with the one of the plurality of thermal injectors; (c) detecting one or more target analytes in a secondary stream exiting the one of the plurality of secondary chromatographic columns; and (a) selectively directing a portion of the primary stream to one of the plurality of thermal injectors and accumulating the portion of the primary stream for a predetermined amount of time; (b) injecting the portion of the primary stream into one of the plurality of secondary chromatographic columns in fluid communication with the one of the plurality of thermal injectors; (c) detecting one or more target analytes in a secondary stream exiting the one of the plurality of secondary chromatographic columns; and repeating (a)-(c) to selectively direct other portions of the primary stream to other thermal injectors of the plurality of thermal injectors and the plurality of secondary chromatographic columns in fluid communication therewith until substantially all of the target analytes in the sample are detected after exiting the plurality of secondary chromatographic columns to provide a comprehensive analysis of the sample, wherein a separation time in each secondary chromatographic column of the plurality of secondary chromatographic columns is less than or equal to a product of the predetermined amount of time and a quantity of secondary chromatographic columns in the plurality of secondary chromatographic columns.