A retrograde delivery catheter (150; 300) for retrograde delivery of a fluid into a coronary sinus, the retrograde delivery catheter (150; 300) comprising: a flexible, elongated shaft (152; 304) having a proximal end and a distal end, the shaft (152; 304) having sufficient length and flexibility so that the proximal end may extend intraluminally through a patient such that when the proximal end is external to the patient, the distal end is positioned in the coronary sinus of the patient, the flexible, elongated shaft (152; 304) defining at least two lumens (310, 312, 314) extending from about the proximal end toward the distal end; and an expandable member (153; 308) positioned at least proximate the distal end of the flexible, elongated shaft (152, 304), the expandable member (153; 308) being configured to at least partially occlude the patient's coronary sinus; an atraumatic distal tip at about the distal end of the flexible, elongated shaft (152; 304); a user interface coupled to the flexible, elongated shaft (152; 304), the user interface being configured to control selective articulation of the distal end of the flexible, elongated shaft (152; 304), wherein the user interface defines at least one pre-set articulation position of the distal end of the flexible, elongated shaft (152; 304), characterized in that the user interface includes a multi-position switch configured to at least partially control selective articulation of the distal end of the flexible, elongated shaft (152; 304), the multi-position switch including: a first position corresponding to an insertion position of the distal end of the flexible, elongated shaft (152; 304); a second position corresponding to an engagement position of the distal end of the flexible, elongated shaft (152; 304), the engagement position corresponding to a stressed position of the user interface, wherein in the engagement position the curvature of the shaft (152; 304) approximates a typical curvature to be expected in the average patient, so as to position the distal tip of the shaft (152; 304) within the patient's coronary sinus; and a third position corresponding to a troubleshooting position of the distal end of the flexible, elongated shaft (152; 304), in which the position of the distal tip is articulated beyond the intermediate, engagement position. a flexible, elongated shaft (152; 304) having a proximal end and a distal end, the shaft (152; 304) having sufficient length and flexibility so that the proximal end may extend intraluminally through a patient such that when the proximal end is external to the patient, the distal end is positioned in the coronary sinus of the patient, the flexible, elongated shaft (152; 304) defining at least two lumens (310, 312, 314) extending from about the proximal end toward the distal end; and an expandable member (153; 308) positioned at least proximate the distal end of the flexible, elongated shaft (152, 304), the expandable member (153; 308) being configured to at least partially occlude the patient's coronary sinus; an atraumatic distal tip at about the distal end of the flexible, elongated shaft (152; 304); a user interface coupled to the flexible, elongated shaft (152; 304), the user interface being configured to control selective articulation of the distal end of the flexible, elongated shaft (152; 304), wherein the user interface defines at least one pre-set articulation position of the distal end of the flexible, elongated shaft (152; 304), characterized in that the user interface includes a multi-position switch configured to at least partially control selective articulation of the distal end of the flexible, elongated shaft (152; 304), the multi-position switch including: a first position corresponding to an insertion position of the distal end of the flexible, elongated shaft (152; 304); a second position corresponding to an engagement position of the distal end of the flexible, elongated shaft (152; 304), the engagement position corresponding to a stressed position of the user interface, wherein in the engagement position the curvature of the shaft (152; 304) approximates a typical curvature to be expected in the average patient, so as to position the distal tip of the shaft (152; 304) within the patient's coronary sinus; and a third position corresponding to a troubleshooting position of the distal end of the flexible, elongated shaft (152; 304), in which the position of the distal tip is articulated beyond the intermediate, engagement position. a first position corresponding to an insertion position of the distal end of the flexible, elongated shaft (152; 304); a second position corresponding to an engagement position of the distal end of the flexible, elongated shaft (152; 304), the engagement position corresponding to a stressed position of the user interface, wherein in the engagement position the curvature of the shaft (152; 304) approximates a typical curvature to be expected in the average patient, so as to position the distal tip of the shaft (152; 304) within the patient's coronary sinus; and a third position corresponding to a troubleshooting position of the distal end of the flexible, elongated shaft (152; 304), in which the position of the distal tip is articulated beyond the intermediate, engagement position.