mhurhangee/ep-ind-claims huggingface dataset:
A polypeptide comprising a truncated von Willebrand Factor and a half-life extending moiety, for use in the treatment of a blood coagulation disorder, said treatment comprising administering the polypeptide to a subject having a blood coagulation disorder and having endogenous Factor VIII (FVIII), wherein the activity level of endogenous FVIII in said subject before treatment with said polypeptide is reduced relative to the activity level of FVIII in normal human plasma provided that the activity level of endogenous FVIII in said subject is at least 0.5% of the activity level of endogenous FVIII in normal human plasma, wherein the truncated VWF comprises an amino acid sequence having a sequence identity of at least 90% to amino acids 764 to 1242 of SEQ ID NO:4, and wherein the polypeptide is capable of binding to endogenous FVIII, wherein the truncated von Willebrand Factor provides for the capability of the polypeptide for binding to endogenous FVIII; wherein the polypeptide is a dimer and the affinity of said dimer to FVIII is greater than the affinity of a monomeric polypeptide to said FVIII, said monomeric polypeptide having the same amino acid sequence as a monomeric subunit of the dimeric polypeptide; wherein the polypeptide has a FVIII binding affinity characterized by a dissociation constant K D of less than 1 nM; wherein the half-life extending moiety is a heterologous amino acid sequence fused to the truncated VWF or is conjugated to the polypeptide; and wherein the endogenous FVIII level is increased following administration of said polypeptide and wherein - (i) said polypeptide is administered for prophylactic prevention of a bleeding event, wherein a) said treatment either does not comprise co-administration of exogenous FVIII, or b) said treatment comprising that an exogenous FVIII is administered and thereby providing for the endogenous FVIII in said subject; or - (ii) said polypeptide is co-administered together with exogenous FVIII for the treatment of a bleeding event or for initiation of a prophylactic treatment regime, wherein for follow-up treatments said polypeptide is administered without co-administration of exogenous FVIII. - (i) said polypeptide is administered for prophylactic prevention of a bleeding event, wherein a) said treatment either does not comprise co-administration of exogenous FVIII, or b) said treatment comprising that an exogenous FVIII is administered and thereby providing for the endogenous FVIII in said subject; or a) said treatment either does not comprise co-administration of exogenous FVIII, or b) said treatment comprising that an exogenous FVIII is administered and thereby providing for the endogenous FVIII in said subject; or - (ii) said polypeptide is co-administered together with exogenous FVIII for the treatment of a bleeding event or for initiation of a prophylactic treatment regime, wherein for follow-up treatments said polypeptide is administered without co-administration of exogenous FVIII.
A fluid pressure regulator comprising: a first stage valve arranged to open and close a fluid flow path to control flow of fluid through the valve, the first stage valve including: a first valve body defining a valve chamber having an outlet opening and an inlet opening; a first valve gasket arranged in the valve chamber at the outlet opening; and a first valve ball movable in the valve chamber to contact the first valve gasket and close the outlet opening; a first stage piston arranged for movement to move the first valve ball relative to the outlet opening and thereby open and close the first stage valve, the piston having an inner side and an outer side; a molded plastic regulator body defining a piston chamber in which the first stage piston is movable and housing the valve chamber; and a lance engaged with an opening of the regulator body, and the lance being arranged to pierce a gas cylinder to open the gas cylinder and conduct pressurized gas from the gas cylinder to the valve chamber, characterised in that the first valve body is a metal component co-molded with the molded plastic regulator body. a first stage valve arranged to open and close a fluid flow path to control flow of fluid through the valve, the first stage valve including: a first valve body defining a valve chamber having an outlet opening and an inlet opening; a first valve gasket arranged in the valve chamber at the outlet opening; and a first valve ball movable in the valve chamber to contact the first valve gasket and close the outlet opening; a first valve body defining a valve chamber having an outlet opening and an inlet opening; a first valve gasket arranged in the valve chamber at the outlet opening; and a first valve ball movable in the valve chamber to contact the first valve gasket and close the outlet opening; a first stage piston arranged for movement to move the first valve ball relative to the outlet opening and thereby open and close the first stage valve, the piston having an inner side and an outer side; a molded plastic regulator body defining a piston chamber in which the first stage piston is movable and housing the valve chamber; and a lance engaged with an opening of the regulator body, and the lance being arranged to pierce a gas cylinder to open the gas cylinder and conduct pressurized gas from the gas cylinder to the valve chamber, characterised in that the first valve body is a metal component co-molded with the molded plastic regulator body.
Frame for a window or a door with a sash/leaf frame with a push-rod fitting, which can be displaced by means of a handle into at least one open position and a locked position, wherein the push-rod fitting comprises at least one locking bolt, which in the locked state engages in a bolt receptacle fastened to a counter-frame part, and a sensor, which is fastened to the frame and has a transmitting element and a detecting element, which is assigned a reflection element for forming a light barrier, wherein the sensor is assigned to the sash/leaf frame and the reflection element is assigned to the counter-frame part, and fixed on the push-rod fitting is a covering element, which can be displaced when the handle is turned and in the open position is arranged in front of the sensor in such a way that at least the transmitting element or detecting element thereof is covered and in the closed position exposes the transmitting element and the detecting element.
Use of trehalose, its derivative or a salt thereof for reducing death of adherent cells due to proteolytic enzyme treatment, wherein the trehalose, its derivative or a salt thereof is used in a cell-washing treatment prior to the proteolytic enzyme treatment, wherein the trehalose, its derivative or a salt thereof used in the cell-washing treatment prior to the proteolytic enzyme treatment is in a physiological aqueous solution in a concentration of 0.1 to 20 (w/v)%, wherein the treatment time of the cell-washing treatment prior to the proteolytic enzyme treatment is in the range of 1 second to 20 minutes, and wherein the trehalose derivative is a glycosyltrehalose in which one or more sugar units are bonded to trehalose as disaccharide.
An electric vacuum cleaner comprising: a base unit; a support unit provided on the base unit; a main body provided on the support unit; a connection pipe having a central axis along a surface orthogonal to a pivot axis of the main body; as dust separation/collection unit housed in the main body and communicatively connected to the connection pipe; an electric blower hosed in the main body and communicatively connected to the dust separation/collection unit; and a flexible dust collection hose connected to the connection pipe and communicatively connected to the dust separation/collection unit; characterised in that, the support unit is an elevation pivot support unit; and the main body is pivotably supported about a pivot axis of the elevation pivot support unit. a base unit; a support unit provided on the base unit; a main body provided on the support unit; a connection pipe having a central axis along a surface orthogonal to a pivot axis of the main body; as dust separation/collection unit housed in the main body and communicatively connected to the connection pipe; an electric blower hosed in the main body and communicatively connected to the dust separation/collection unit; and a flexible dust collection hose connected to the connection pipe and communicatively connected to the dust separation/collection unit; characterised in that, the support unit is an elevation pivot support unit; and the main body is pivotably supported about a pivot axis of the elevation pivot support unit. the support unit is an elevation pivot support unit; and the main body is pivotably supported about a pivot axis of the elevation pivot support unit.
A casing milling system for wellbores, the milling system comprising: an upper mill portion comprising a mill that has at least one cutting element, an axially extending engagement arm downhole from the mill, and an orientation and locking mechanism on a downhole end of engagement arm; and a lower guide system comprising a tubular mill housing having an opening formed in a portion of tubular mill housing with a track formed along a portion of the length of the opening, the track in use being engaged by the upper mill portion, an elongated traveling guide arm extending down from the tubular mill housing and defined along an axis, and a guide assembly disposed to slidingly receive the elongated traveling guide arm in order to guide the mill along a length of casing to be milled, wherein the guide assembly includes a tubular body, a portion of which defines a cylinder section, and a latch assembly to secure the guide assembly within a wellbore. an upper mill portion comprising a mill that has at least one cutting element, an axially extending engagement arm downhole from the mill, and an orientation and locking mechanism on a downhole end of engagement arm; and a lower guide system comprising a tubular mill housing having an opening formed in a portion of tubular mill housing with a track formed along a portion of the length of the opening, the track in use being engaged by the upper mill portion, an elongated traveling guide arm extending down from the tubular mill housing and defined along an axis, and a guide assembly disposed to slidingly receive the elongated traveling guide arm in order to guide the mill along a length of casing to be milled, wherein the guide assembly includes a tubular body, a portion of which defines a cylinder section, and a latch assembly to secure the guide assembly within a wellbore.
A system comprising: a plurality of light emitting diodes, LEDs; and a control module configured to generate pulse width modulated, PWM, pulses to drive the LEDs, wherein the LEDs and the control module are integrated in an integrated circuit, IC, package (300;350), and wherein the LEDs and the control module are arranged on a die in the IC package (300;350), the die characterised by comprising: a ceramic layer having a first side, and a second side that is opposite to the first side, wherein the LEDs are arranged adjacent to the first side of the ceramic layer; and a silicon layer including the control module, wherein the silicon layer is adjacent to the second side of the ceramic layer, and wherein the LEDs are electrically connected to the silicon layer. a plurality of light emitting diodes, LEDs; and a control module configured to generate pulse width modulated, PWM, pulses to drive the LEDs, wherein the LEDs and the control module are integrated in an integrated circuit, IC, package (300;350), and wherein the LEDs and the control module are arranged on a die in the IC package (300;350), the die characterised by comprising: a ceramic layer having a first side, and a second side that is opposite to the first side, wherein the LEDs are arranged adjacent to the first side of the ceramic layer; and a silicon layer including the control module, wherein the silicon layer is adjacent to the second side of the ceramic layer, and wherein the LEDs are electrically connected to the silicon layer. a ceramic layer having a first side, and a second side that is opposite to the first side, wherein the LEDs are arranged adjacent to the first side of the ceramic layer; and a silicon layer including the control module, wherein the silicon layer is adjacent to the second side of the ceramic layer, and wherein the LEDs are electrically connected to the silicon layer.
Vehicle with a vehicle-internal communication bus carrying vehicle data, a communication module connected thereto for radio communications of the vehicle, and a rescue drone detachably anchored to the vehicle, characterised in that the rescue drone is connected to the communication bus in the anchored state and contains at least said communication module which sends and receives the radio communications of the vehicle in the anchored state, wherein the rescue drone is configured to utilise the communication module for its own radio communications in the detached state.
An apparatus comprising: a fastener installation tool (602, 902); an elongate structure (604, 904)configured for attachment to the fastener installation tool, in which the elongate structure has a length; and a camera (606, 908) associated with the fastener installation tool (602, 902), in which the camera is configured with a focal length (824, 1124) corresponding to the length of the elongate structure, and configured to capture an image of at least a portion of a fastener system when the elongate structure is placed against a surface of an object (802, 1102) on which the fastener system is located, wherein the elongate structure (604, 904) has a channel (620, 926) through which the camera captures the image. a fastener installation tool (602, 902); an elongate structure (604, 904)configured for attachment to the fastener installation tool, in which the elongate structure has a length; and a camera (606, 908) associated with the fastener installation tool (602, 902), in which the camera is configured with a focal length (824, 1124) corresponding to the length of the elongate structure, and configured to capture an image of at least a portion of a fastener system when the elongate structure is placed against a surface of an object (802, 1102) on which the fastener system is located, wherein the elongate structure (604, 904) has a channel (620, 926) through which the camera captures the image.
A method of forming a lens package, wherein the lens package comprises: a bulb having a volume and a perimeter; a cover sealed to said bulb; and a contact lens contained in solution in said bulb; and wherein said cover is a foil; the method comprising heat sealing said foil to said bulb using a heat seal die to form a heat seal ring around the perimeter of the bulb; wherein a part in the middle of the heat seal die is pushed onto the foil as the die affixes the foil to the bulb to form a concavity in said heat sealed foil, so that the foil projects inwards from the plane of the heat seal ring which joins the foil to the bulb, and wherein the concavity displaces volume from the volume of the bulb. a bulb having a volume and a perimeter; a cover sealed to said bulb; and a contact lens contained in solution in said bulb; and
A precoding method for a cross-polarized antenna array, the cross-polarized antenna array comprising a first group of coplanar polarized antennas and a second group of coplanar polarized antennas, the method comprising the following steps: generating, for at least one layer of data stream, a feedback codebook comprising a plurality of codewords; receiving a selection of the codeword in the feedback codebook; determining a corresponding codeword from the feedback codebook according to the received selection; generating a precoding matrix based on the determined codeword to precode the at least one layer of data stream; wherein each codeword in the feedback codebook comprises a first coefficient portion corresponding to the first group of coplanar polarized antennas and a second coefficient portion corresponding to the second group of coplanar polarized antennas, and there is a complex scaling relation between the coefficients in the first coefficient portion and the second coefficient portion corresponding to the same layer of data stream, wherein the complex scaling relation comprises amplitudes and phases that are independently selectable for each layer; the coefficient in the feedback codebook corresponding to each layer of data stream is generated according to a plurality of complex scaling coefficients consisting of a plurality of candidate amplitudes and a plurality of candidate phases, and a plurality of candidate single-polarized coefficients. generating, for at least one layer of data stream, a feedback codebook comprising a plurality of codewords; receiving a selection of the codeword in the feedback codebook; determining a corresponding codeword from the feedback codebook according to the received selection; generating a precoding matrix based on the determined codeword to precode the at least one layer of data stream; wherein each codeword in the feedback codebook comprises a first coefficient portion corresponding to the first group of coplanar polarized antennas and a second coefficient portion corresponding to the second group of coplanar polarized antennas, and there is a complex scaling relation between the coefficients in the first coefficient portion and the second coefficient portion corresponding to the same layer of data stream, wherein the complex scaling relation comprises amplitudes and phases that are independently selectable for each layer; the coefficient in the feedback codebook corresponding to each layer of data stream is generated according to a plurality of complex scaling coefficients consisting of a plurality of candidate amplitudes and a plurality of candidate phases, and a plurality of candidate single-polarized coefficients.
A method of providing a signal between a tag of a plurality of tags and an interrogator in an RFID system to determine the location of the tag relative to a coil of a plurality of coils associated with the interrogator, wherein energising the coil provides a magnetic field having a field strength inside the coil that is greater than the field strength outside of that coil, the method comprising steps of: (a) energising each coil to generate a respective first magnetic field having a first field strength; (b) increasing the energisation of each coil to generate a progressively larger field strength than the first magnetic field; (c) storing a value for the tag indicative of the field strength when the tag first becomes powered up or active, whereby the tag provides a signal indicative of the field strength at which the tag first becomes powered up or active; and (d) correlating the field strength at which the tag first becomes powered up or active, including correlating the tag response with a particular coil based upon the field strength at which that tag is first powered up or activated, to determine the tag location. (a) energising each coil to generate a respective first magnetic field having a first field strength; (b) increasing the energisation of each coil to generate a progressively larger field strength than the first magnetic field; (c) storing a value for the tag indicative of the field strength when the tag first becomes powered up or active, whereby the tag provides a signal indicative of the field strength at which the tag first becomes powered up or active; and (d) correlating the field strength at which the tag first becomes powered up or active, including correlating the tag response with a particular coil based upon the field strength at which that tag is first powered up or activated, to determine the tag location.
An upper tight-contact jig for welding used to manufacture an electrode terminal, the upper tight-contact jig comprising: a ring-shaped spray portion configured to, in use, spray an inert gas so as to be brought into tight contact with one surface of a weld portion of a plurality of secondary batteries, and an outer upper tight-contact jig defining an outer surface of the ring-shaped spray portion and an inner upper tight-contact jig defining an inner surface of the ring-shaped spray portion, wherein a bottom surface of the outer upper tight-contact jig is adapted to abut, in use, the weld portion and a bottom surface of the inner upper tight-contact jig is spaced apart therefrom by a predetermined height to form the ring-shaped spray portion, and being characterised by a sectional area of the ring-shaped spray portion gradually decreases from an upper surface to a bottom surface of the upper tight-contact jig. a ring-shaped spray portion configured to, in use, spray an inert gas so as to be brought into tight contact with one surface of a weld portion of a plurality of secondary batteries, and an outer upper tight-contact jig defining an outer surface of the ring-shaped spray portion and an inner upper tight-contact jig defining an inner surface of the ring-shaped spray portion, wherein a bottom surface of the outer upper tight-contact jig is adapted to abut, in use, the weld portion and a bottom surface of the inner upper tight-contact jig is spaced apart therefrom by a predetermined height to form the ring-shaped spray portion, and being characterised by a sectional area of the ring-shaped spray portion gradually decreases from an upper surface to a bottom surface of the upper tight-contact jig.
Heat storage tank comprising an envelope with a longitudinal axis, the longitudinal axis being intended to be oriented substantially vertically, said envelope being filled with a heat transfer liquid and solid heat storage elements, an upper longitudinal end fitted with an upper means for collecting and supplying a liquid at a first temperature and a second lower longitudinal end provided with lower means for collecting and supplying a liquid at a second temperature, said solid heat storage elements being distributed across at least two beds (TH1, TH2, TH3) superposed along the longitudinal axis, separated by a layer of liquid (L1, L2, L3), the liquid being capable of flowing between the upper longitudinal end and the lower longitudinal end characterised in that it comprises at least one first intermediate means of collecting and distributing arranged in the liquid layer and at least one second intermediate means for collecting and distributing arranged in the layer of liquid or immediately above or immediately below the layer of liquid partially or entirely, in that the first intermediate means of collecting and distributing is oriented in such a way as to collect and distribute the fluid in the bed of solid elements located above the first intermediate means of collecting and distributing and in that the second intermediate means for collecting and distributing is oriented in such a way as to collect and distribute the fluid in the bed of solid elements located below the second intermediate means for collecting and distributing.