A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is C 2 -C 10 hydroxyalkyl, optionally substituted with 1-3 R 5; R 2 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, C 1 -C 6 hydroxyalkyl, or C 1 -C 6 alkoxy; R 3 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 3 -C 10 cycloalkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, alkylthio, thionyl, sulfonyl, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, optionally substituted with 1-5 R 5; R 4 is C 1 -C 6 alkyl, C 1 -C 6 acyl, cycloalkyl, alkoxy, C 3 -C 10 cycloalkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, alkylthio, thionyl, sulfonyl, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, optionally substituted with 1-5 R 5; each R 5 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, amino, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, each of which is optionally substituted with 1-5 R 6; and each R 6 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, cyano, nitro, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, - C O-C 1 -C 6 alkyl, -C OH, -C O-C 1 -C 6 alkyl, -C -C 1 -C 6 alkyl, acyl, nitro, or cyano. R 1 is C 2 -C 10 hydroxyalkyl, optionally substituted with 1-3 R 5; R 2 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 10 cycloalkyl, C 1 -C 6 hydroxyalkyl, or C 1 -C 6 alkoxy; R 3 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 3 -C 10 cycloalkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, alkylthio, thionyl, sulfonyl, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, optionally substituted with 1-5 R 5; R 4 is C 1 -C 6 alkyl, C 1 -C 6 acyl, cycloalkyl, alkoxy, C 3 -C 10 cycloalkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, alkylthio, thionyl, sulfonyl, sulfonamidyl, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, 5-14-membered heteroaryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, 3-18-membered heterocycloalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, urea, sulfonylurea, nitro, or cyano, optionally substituted with 1-5 R 5; each R 5 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 acyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, amino, C 6 -C 12 aryl, 5-14-membered heteroaryl, C 6 -C 12 aryl-C 1 -C 6 alkyl, C 6 -C 12 aryloxy, -O-C 6 -C 12 aryl-C 1 -C 6 alkyl, -O- C 1 -C 6 alkyl-C 6 -C 12 aryl, -C 6 -C 12 aryl-C 1 -C 6 alky-O, 5-14-membered heteroaryloxy, each of which is optionally substituted with 1-5 R 6; and each R 6 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 4 -C 10 cycloalkyloxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 2 -C 12 dialkylamino, cyano, nitro, -C NH-,-C N-C 1 -C 6 alkyl-,-NHC -, -N- C 1 -C 6 alkyl C -, - C O-C 1 -C 6 alkyl, -C OH, -C O-C 1 -C 6 alkyl, -C -C 1 -C 6 alkyl, acyl, nitro, or cyano.