A compound of the formula; wherein R 1 is a cycloalkyl or an alkyl, R 22 is 1) an optionally substituted aryl, 2) an optionally substituted pyridyl, 3) an optionally substituted pyrazolopyridyl, 4) an optionally substituted indolyl, 5) an optionally substituted benzofuranyl, 6) an optionally substituted quinolyl, 7) an optionally substituted chromanyl, 8) an optionally substituted dihydrobenzofuranyl, 9) an optionally substituted indazolyl, 10) an optionally substituted pyrrolopyridinyl, 11) an optionally substituted benzoisoxazolyl, 12) an optionally substituted indolinyl, 13) an optionally substituted quinazolinyl, 14) an optionally substituted dihydroquinazolinyl, 15) an optionally substituted furopyridyl, 16) an optionally substituted isoquinolyl, 17) an optionally substituted pyrrolopyrimidinyl, 18) an optionally substituted tetrahydroquinolyl, 19) an optionally substituted tetrahydroindazolyl, 20) an optionally substituted tetrahydrocyclopentapyrazolyl, 21) an optionally substituted pyrrolyl, 22) an optionally substituted imidazolyl, 23) an optionally substituted pyrazolyl, 24) an optionally substituted thienyl, 25) an optionally substituted thiazolyl, 26) an optionally substituted triazolyl, 27) an optionally substituted pyrimidinyl, 28) an optionally substituted pyrazyl, 29) an optionally substituted imidazopyridinyl, or 30) an optionally substituted pyrrolopyrazyl, R is a C 1 -C 4 alkyl group, one of R 4 and R 5 is a group selected from 1) a carbamoyl optionally substituted with an alkyl which is optionally substituted with 1 or 2 phenyl, 2) an alkyl optionally substituted with an alkoxy optionally substituted with a halogen or a phenyl; a halogen; a hydroxyl; an amino optionally substituted with 1 or 2 alkyls; or cyano; and 3) an alkoxycarbonyl, or a pharmaceutically acceptable salt thereof, the other, R 3 and R 6, are the same or different, a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof. wherein R 1 is a cycloalkyl or an alkyl, R 22 is 1) an optionally substituted aryl, 2) an optionally substituted pyridyl, 3) an optionally substituted pyrazolopyridyl, 4) an optionally substituted indolyl, 5) an optionally substituted benzofuranyl, 6) an optionally substituted quinolyl, 7) an optionally substituted chromanyl, 8) an optionally substituted dihydrobenzofuranyl, 9) an optionally substituted indazolyl, 10) an optionally substituted pyrrolopyridinyl, 11) an optionally substituted benzoisoxazolyl, 12) an optionally substituted indolinyl, 13) an optionally substituted quinazolinyl, 14) an optionally substituted dihydroquinazolinyl, 15) an optionally substituted furopyridyl, 16) an optionally substituted isoquinolyl, 17) an optionally substituted pyrrolopyrimidinyl, 18) an optionally substituted tetrahydroquinolyl, 19) an optionally substituted tetrahydroindazolyl, 20) an optionally substituted tetrahydrocyclopentapyrazolyl, 21) an optionally substituted pyrrolyl, 22) an optionally substituted imidazolyl, 23) an optionally substituted pyrazolyl, 24) an optionally substituted thienyl, 25) an optionally substituted thiazolyl, 26) an optionally substituted triazolyl, 27) an optionally substituted pyrimidinyl, 28) an optionally substituted pyrazyl, 29) an optionally substituted imidazopyridinyl, or 30) an optionally substituted pyrrolopyrazyl, R is a C 1 -C 4 alkyl group, one of R 4 and R 5 is a group selected from 1) a carbamoyl optionally substituted with an alkyl which is optionally substituted with 1 or 2 phenyl, 2) an alkyl optionally substituted with an alkoxy optionally substituted with a halogen or a phenyl; a halogen; a hydroxyl; an amino optionally substituted with 1 or 2 alkyls; or cyano; and 3) an alkoxycarbonyl, or a pharmaceutically acceptable salt thereof, 1) a carbamoyl optionally substituted with an alkyl which is optionally substituted with 1 or 2 phenyl, 2) an alkyl optionally substituted with an alkoxy optionally substituted with a halogen or a phenyl; a halogen; a hydroxyl; an amino optionally substituted with 1 or 2 alkyls; or cyano; and 3) an alkoxycarbonyl, the other, R 3 and R 6, are the same or different, a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.