A combined stent delivery and occlusion device comprising: a proximal manifold including: an infusion port; a stent balloon inflation port; a catheter extending distally from the manifold and defining an inflation lumen in fluid communication with the stent balloon inflation port; a therapeutic agent port; a stent balloon near a distal end of the catheter and surrounding the catheter, the stent balloon in fluid communication with the inflation lumen; and a stent surrounding the stent balloon; wherein the catheter further defines an infusion lumen in fluid communication with the infusion port, the infusion lumen extending to the distal end of the catheter; wherein the catheter further defines a therapeutic agent lumen in fluid communication with the therapeutic agent port, the therapeutic agent lumen extending to the distal end of the catheter; and characterized in that the combined stent delivery and occlusion device further includes a guidewire, the guidewire comprising a pressure and temperature sensor to provide real-time measurement of distal vessel pressures and temperatures at a location distal to the device; wherein, in use, the device is configured to perform the following steps: (a) the infusion lumen is used as a guidewire lumen while the device is being advanced to the target site; (b) once the device has reached its target location, the balloon is inflated causing the stent to expand against the native tissue, the inflation of the balloon also results in an occlusion of the vessel; (c) while the balloon remains inflated and the vessel occluded, a cardioprotective agent is infused via the infusion port and through the infusion lumen, exiting the lumen at the distal end of the catheter, downstream of the balloon; and (d) once the desired cardio-protective effect has been achieved, as measured by the pressure and temperature sensor on the guidewire, the balloon is deflated, allowing normal blood reperfusion of the coronary circulation. a proximal manifold including: an infusion port; a stent balloon inflation port; an infusion port; a stent balloon inflation port; a catheter extending distally from the manifold and defining an inflation lumen in fluid communication with the stent balloon inflation port; a therapeutic agent port; a stent balloon near a distal end of the catheter and surrounding the catheter, the stent balloon in fluid communication with the inflation lumen; and a stent surrounding the stent balloon; wherein the catheter further defines an infusion lumen in fluid communication with the infusion port, the infusion lumen extending to the distal end of the catheter; wherein the catheter further defines a therapeutic agent lumen in fluid communication with the therapeutic agent port, the therapeutic agent lumen extending to the distal end of the catheter; and characterized in that the combined stent delivery and occlusion device further includes a guidewire, the guidewire comprising a pressure and temperature sensor to provide real-time measurement of distal vessel pressures and temperatures at a location distal to the device; wherein, in use, the device is configured to perform the following steps: (a) the infusion lumen is used as a guidewire lumen while the device is being advanced to the target site; (b) once the device has reached its target location, the balloon is inflated causing the stent to expand against the native tissue, the inflation of the balloon also results in an occlusion of the vessel; (c) while the balloon remains inflated and the vessel occluded, a cardioprotective agent is infused via the infusion port and through the infusion lumen, exiting the lumen at the distal end of the catheter, downstream of the balloon; and (d) once the desired cardio-protective effect has been achieved, as measured by the pressure and temperature sensor on the guidewire, the balloon is deflated, allowing normal blood reperfusion of the coronary circulation. (a) the infusion lumen is used as a guidewire lumen while the device is being advanced to the target site; (b) once the device has reached its target location, the balloon is inflated causing the stent to expand against the native tissue, the inflation of the balloon also results in an occlusion of the vessel; (c) while the balloon remains inflated and the vessel occluded, a cardioprotective agent is infused via the infusion port and through the infusion lumen, exiting the lumen at the distal end of the catheter, downstream of the balloon; and (d) once the desired cardio-protective effect has been achieved, as measured by the pressure and temperature sensor on the guidewire, the balloon is deflated, allowing normal blood reperfusion of the coronary circulation.