A syringe-based device for procuring bodily fluid samples comprising: (a) a housing including a proximal end portion and a distal end portion and defining an inner volume therebetween, the proximal end portion being open and the distal end portion having a port configured to be coupled to a lumen-defining device configured to receive bodily fluids; and (b) an actuator mechanism including a proximal end portion and a distal end portion, the actuator mechanism being retained at least partially within the inner volume defined by the housing and movable relative to the housing, characterized in that the actuator mechanism includes; (i) a pre-sample reservoir having a proximal end and a distal end, wherein the pre-sample reservoir is fluidically coupleable to the port and defines a first fluid reservoir; (ii) a plunger having a proximal end and a distal end, the distal end of the plunger being associated with the proximal end of the pre-sample reservoir such that distal movement of the plunger correspondingly moves the pre-sample reservoir distally, wherein the plunger includes at least one projection; (iii) a removable plunger cap, the removable plunger cap defining a cavity, wherein the plunger translates within the cavity defined by the removable plunger cap until the at least one projection engages a catch such that the removable plunger cap and the plunger are coupled when the at least one projection engages the catch; (iv) a plunger tube, the plunger tube being selectively engaged with the removable plunger cap, wherein the plunger tube includes a shrouded cannula assembly; (v) a valve, the valve being coupled with an attachment element of the plunger tube such that the valve is fluidically coupled with the shrouded cannula assembly; and (vi) a plunger seal, the plunger seal being coupled with the valve and plunger tube, wherein the plunger seal is movable relative to the housing to at least partially define a second fluid reservoir; and wherein the actuator mechanism transitions from a first configuration in which a bodily fluid flows from the port to the first fluid reservoir, and a second configuration in which the bodily fluid flows from the port to the second fluid reservoir. (a) a housing including a proximal end portion and a distal end portion and defining an inner volume therebetween, the proximal end portion being open and the distal end portion having a port configured to be coupled to a lumen-defining device configured to receive bodily fluids; and (b) an actuator mechanism including a proximal end portion and a distal end portion, the actuator mechanism being retained at least partially within the inner volume defined by the housing and movable relative to the housing, characterized in that the actuator mechanism includes; (i) a pre-sample reservoir having a proximal end and a distal end, wherein the pre-sample reservoir is fluidically coupleable to the port and defines a first fluid reservoir; (ii) a plunger having a proximal end and a distal end, the distal end of the plunger being associated with the proximal end of the pre-sample reservoir such that distal movement of the plunger correspondingly moves the pre-sample reservoir distally, wherein the plunger includes at least one projection; (iii) a removable plunger cap, the removable plunger cap defining a cavity, wherein the plunger translates within the cavity defined by the removable plunger cap until the at least one projection engages a catch such that the removable plunger cap and the plunger are coupled when the at least one projection engages the catch; (iv) a plunger tube, the plunger tube being selectively engaged with the removable plunger cap, wherein the plunger tube includes a shrouded cannula assembly; (v) a valve, the valve being coupled with an attachment element of the plunger tube such that the valve is fluidically coupled with the shrouded cannula assembly; and (vi) a plunger seal, the plunger seal being coupled with the valve and plunger tube, wherein the plunger seal is movable relative to the housing to at least partially define a second fluid reservoir; and wherein the actuator mechanism transitions from a first configuration in which a bodily fluid flows from the port to the first fluid reservoir, and a second configuration in which the bodily fluid flows from the port to the second fluid reservoir. (i) a pre-sample reservoir having a proximal end and a distal end, wherein the pre-sample reservoir is fluidically coupleable to the port and defines a first fluid reservoir; (ii) a plunger having a proximal end and a distal end, the distal end of the plunger being associated with the proximal end of the pre-sample reservoir such that distal movement of the plunger correspondingly moves the pre-sample reservoir distally, wherein the plunger includes at least one projection; (iii) a removable plunger cap, the removable plunger cap defining a cavity, wherein the plunger translates within the cavity defined by the removable plunger cap until the at least one projection engages a catch such that the removable plunger cap and the plunger are coupled when the at least one projection engages the catch; (iv) a plunger tube, the plunger tube being selectively engaged with the removable plunger cap, wherein the plunger tube includes a shrouded cannula assembly; (v) a valve, the valve being coupled with an attachment element of the plunger tube such that the valve is fluidically coupled with the shrouded cannula assembly; and (vi) a plunger seal, the plunger seal being coupled with the valve and plunger tube, wherein the plunger seal is movable relative to the housing to at least partially define a second fluid reservoir; and