A body fluid analyte detection device, wherein, including: a transmitter (12, 22), provided with at least one first fastener part (121, 221); a bottom case (10, 20), provided with at least one second fastener part (101, 201) corresponding to the at least one first fastener part (121, 221), and with the at least one first fastener part (121, 221) and the at least one second fastener part (101, 201) fastening with each other, the transmitter (12, 22) is assembled on the bottom case (10, 20), and the bottom case (10, 20) comprises at least one fixed portion and at least one force-receiving portion, and wherein the bottom case (10, 20) and the transmitter (12, 22) are configured to be separated when the at least one fixed portion is fixed by a finger or other structure and a force is applied, from another finger or other auxiliary structures, to the at least one force-receiving portion in one direction leading to a bottom case failure for separating at least one pair of the at least one first fastener part (121, 221) and the at least one second fastener part (101, 201) mutually fastened with each other, thus separating the bottom case (10, 20) and the transmitter (12, 22); a sensor, assembled to the bottom case (10, 20), wherein the sensor is configured to detect an analyte parameter of body fluid, and the sensor is connected with the transmitter (12, 22) to transmit a parameter signal; and a battery, for powering the transmitter (12, 22), wherein the battery is assembled in the bottom case (10, 20) or in the transmitter (12, 22), and a part holding the battery which is a battery holding portion (123, 203), wherein the bottom case failure includes one or more combinations of the fracture of a bottom board or a side wall of the bottom case (10, 20), breakage of the bottom case (10, 20), breakage of the second fastener part (101, 201), or plastic deformation of the bottom case (10, 20). a transmitter (12, 22), provided with at least one first fastener part (121, 221); a bottom case (10, 20), provided with at least one second fastener part (101, 201) corresponding to the at least one first fastener part (121, 221), and with the at least one first fastener part (121, 221) and the at least one second fastener part (101, 201) fastening with each other, the transmitter (12, 22) is assembled on the bottom case (10, 20), and the bottom case (10, 20) comprises at least one fixed portion and at least one force-receiving portion, and wherein the bottom case (10, 20) and the transmitter (12, 22) are configured to be separated when the at least one fixed portion is fixed by a finger or other structure and a force is applied, from another finger or other auxiliary structures, to the at least one force-receiving portion in one direction leading to a bottom case failure for separating at least one pair of the at least one first fastener part (121, 221) and the at least one second fastener part (101, 201) mutually fastened with each other, thus separating the bottom case (10, 20) and the transmitter (12, 22); a sensor, assembled to the bottom case (10, 20), wherein the sensor is configured to detect an analyte parameter of body fluid, and the sensor is connected with the transmitter (12, 22) to transmit a parameter signal; and a battery, for powering the transmitter (12, 22), wherein the battery is assembled in the bottom case (10, 20) or in the transmitter (12, 22), and a part holding the battery which is a battery holding portion (123, 203), wherein the bottom case failure includes one or more combinations of the fracture of a bottom board or a side wall of the bottom case (10, 20), breakage of the bottom case (10, 20), breakage of the second fastener part (101, 201), or plastic deformation of the bottom case (10, 20).