Macromolecular compounds having the structure: (Nuc-Linker)n-Marker wherein: nuc is a nucleotide or nucleoside (nuc-component); linker is a linker component which comprises the following parts: a) coupling unit L is a part of the linker, which provides linkage between the nuc and the rest of the linker b) a polymer is a part of the linker, said polymer is water soluble-polymer with an average length between 50 and 20000 atoms (chain atoms) and said polymer comprises identical or different monomers independently selected from the group of polymers: polyethylene glycol, polysaccharides, dextran, polyamides, polypeptides, polyphosphates, polyacetates, polyalkyleneglycoles, copolymers from ethyleneglycol and propyleneglycol, polyolefinic alcohols, polyvinylpyrrolidones, poly(hydroxyalkylmethacrylamides), polyhydroxyalkylmethacrylates, poly(x-hydroxy) acids, polyacrylic acid, polyacrylamide, and polyvinylalcohol c) coupling unit T is a part of the linker which provides linkage between the marker and the rest of the linker; marker is a macromolecular marker component comprising at least one macromolecule with molecular weight of at least 2000 Da, or a plurality of low molecular weight marker units with molecular weight below 2000 Da or a combination of a plurality of low molecular weight marker unit with a molecular weight below 2000 Da and at least one macromolecule with a molecular weight of at least 2000 Da; (n) is a positive integer between 1 and 100 nuc is a nucleotide or nucleoside (nuc-component); linker is a linker component which comprises the following parts: a) coupling unit L is a part of the linker, which provides linkage between the nuc and the rest of the linker b) a polymer is a part of the linker, said polymer is water soluble-polymer with an average length between 50 and 20000 atoms (chain atoms) and said polymer comprises identical or different monomers independently selected from the group of polymers: polyethylene glycol, polysaccharides, dextran, polyamides, polypeptides, polyphosphates, polyacetates, polyalkyleneglycoles, copolymers from ethyleneglycol and propyleneglycol, polyolefinic alcohols, polyvinylpyrrolidones, poly(hydroxyalkylmethacrylamides), polyhydroxyalkylmethacrylates, poly(x-hydroxy) acids, polyacrylic acid, polyacrylamide, and polyvinylalcohol c) coupling unit T is a part of the linker which provides linkage between the marker and the rest of the linker; a) coupling unit L is a part of the linker, which provides linkage between the nuc and the rest of the linker b) a polymer is a part of the linker, said polymer is water soluble-polymer with an average length between 50 and 20000 atoms (chain atoms) and said polymer comprises identical or different monomers independently selected from the group of polymers: polyethylene glycol, polysaccharides, dextran, polyamides, polypeptides, polyphosphates, polyacetates, polyalkyleneglycoles, copolymers from ethyleneglycol and propyleneglycol, polyolefinic alcohols, polyvinylpyrrolidones, poly(hydroxyalkylmethacrylamides), polyhydroxyalkylmethacrylates, poly(x-hydroxy) acids, polyacrylic acid, polyacrylamide, and polyvinylalcohol polyethylene glycol, polysaccharides, dextran, polyamides, polypeptides, polyphosphates, polyacetates, polyalkyleneglycoles, copolymers from ethyleneglycol and propyleneglycol, polyolefinic alcohols, polyvinylpyrrolidones, poly(hydroxyalkylmethacrylamides), polyhydroxyalkylmethacrylates, poly(x-hydroxy) acids, polyacrylic acid, polyacrylamide, and polyvinylalcohol c) coupling unit T is a part of the linker which provides linkage between the marker and the rest of the linker; marker is a macromolecular marker component comprising at least one macromolecule with molecular weight of at least 2000 Da, or a plurality of low molecular weight marker units with molecular weight below 2000 Da or a combination of a plurality of low molecular weight marker unit with a molecular weight below 2000 Da and at least one macromolecule with a molecular weight of at least 2000 Da; (n) is a positive integer between 1 and 100