A system for treating a condition within a sino-nasal cavity of a patient, the system comprising: a treatment device including an end effector (114; 214; 314) comprising one or more electrodes (244, 336), a subset of the one or more electrodes being configured to deliver non-therapeutic stimulating energy at a frequency/waveform to respective positions at one or more target sites to thereby sense at least one of physiological properties, bioelectric properties, and thermal properties of one or more tissues at the one or more target sites; a database containing a plurality of profiles (402 -402(n)) of known tissue types, each profile including electric signature data for an associated tissue type including bioelectric properties of the tissue type, including ablation profiles with known temperature threshold values associated with successful and unsuccessful ablation and/or modulation treatment of the tissue type while avoiding vaporization and/or aerosolization of the tissue type; and a controller operably associated with the treatment device and configured to control delivery of treatment energy from the one or more electrodes to the one or more tissues at the one or more target sites within a sino-nasal cavity of the patient to ablate and/or modulate targeted tissue in that the controller is configured to: receive identifying data from the treatment device, the identifying data including the at least one of physiological properties, bioelectric properties, and thermal properties of the one or more tissues; process the identifying data to identify one or more tissue types at the one or more target sites by comparing the identifying data with the electric signature data; and upon a positive correlation of the identifying data and the electric signature data, determine one or more respective treatment patterns for controlling the delivery of treatment energy based on the one or more tissue types identified. a treatment device including an end effector (114; 214; 314) comprising one or more electrodes (244, 336), a subset of the one or more electrodes being configured to deliver non-therapeutic stimulating energy at a frequency/waveform to respective positions at one or more target sites to thereby sense at least one of physiological properties, bioelectric properties, and thermal properties of one or more tissues at the one or more target sites; a database containing a plurality of profiles (402 -402(n)) of known tissue types, each profile including electric signature data for an associated tissue type including bioelectric properties of the tissue type, including ablation profiles with known temperature threshold values associated with successful and unsuccessful ablation and/or modulation treatment of the tissue type while avoiding vaporization and/or aerosolization of the tissue type; and a controller operably associated with the treatment device and configured to control delivery of treatment energy from the one or more electrodes to the one or more tissues at the one or more target sites within a sino-nasal cavity of the patient to ablate and/or modulate targeted tissue in that the controller is configured to: receive identifying data from the treatment device, the identifying data including the at least one of physiological properties, bioelectric properties, and thermal properties of the one or more tissues; process the identifying data to identify one or more tissue types at the one or more target sites by comparing the identifying data with the electric signature data; and upon a positive correlation of the identifying data and the electric signature data, determine one or more respective treatment patterns for controlling the delivery of treatment energy based on the one or more tissue types identified. receive identifying data from the treatment device, the identifying data including the at least one of physiological properties, bioelectric properties, and thermal properties of the one or more tissues; process the identifying data to identify one or more tissue types at the one or more target sites by comparing the identifying data with the electric signature data; and upon a positive correlation of the identifying data and the electric signature data, determine one or more respective treatment patterns for controlling the delivery of treatment energy based on the one or more tissue types identified.