A biosensor system for determining an analyte concentration in a biological sample, comprising: a test sensor having a sample interface adjacent to a reservoir formed by a strip; a measurement device having a processor connected to a sensor interface, the sensor interface having electrical communication with the sample interface, and the processor having electrical communication with a storage medium; and wherein the sample interface includes conductors connected to a working electrode and a counter electrode from which analytic output signals are measured, and conductors connected to an additional electrode from which a secondary output signal describing the hematocrit content of the sample is independent measured; and where the test sensor and measurement device generate the analytic and secondary output signal from a biological sample in the reservoir, where the input signal applied to the working counter electrodes includes multiple pulses and where a second input signal is applied to the additional electrode to generate the secondary output signal; and where the processor determines at least one index function from the output signals, where the processor determines the analyte concentration in the biological sample from the analytic output signals and a slope compensation equation responsive to the at least one index function, where the slope compensation equation includes at least one reference correlation and at least one slope deviation, characterized in that the index function includes: a) terms including individual ratio indices extracted from the analytic output signals, wherein the ratios compare intermediate signal values between separate pulse-signal decay cycles, b) interaction terms between the ratio indices extracted from the analytic output signal, and each of the temperature, secondary output signal and determined analyte concentration of the sample without compensation, and c) a term including the hematocrit content determined from the at least one secondary output signal, wherein the terms are modified by weighing coefficients. a test sensor having a sample interface adjacent to a reservoir formed by a strip; a measurement device having a processor connected to a sensor interface, the sensor interface having electrical communication with the sample interface, and the processor having electrical communication with a storage medium; and wherein the sample interface includes conductors connected to a working electrode and a counter electrode from which analytic output signals are measured, and conductors connected to an additional electrode from which a secondary output signal describing the hematocrit content of the sample is independent measured; and where the test sensor and measurement device generate the analytic and secondary output signal from a biological sample in the reservoir, where the input signal applied to the working counter electrodes includes multiple pulses and where a second input signal is applied to the additional electrode to generate the secondary output signal; and where the processor determines at least one index function from the output signals, where the processor determines the analyte concentration in the biological sample from the analytic output signals and a slope compensation equation responsive to the at least one index function, where the slope compensation equation includes at least one reference correlation and at least one slope deviation, characterized in that the index function includes: a) terms including individual ratio indices extracted from the analytic output signals, wherein the ratios compare intermediate signal values between separate pulse-signal decay cycles, b) interaction terms between the ratio indices extracted from the analytic output signal, and each of the temperature, secondary output signal and determined analyte concentration of the sample without compensation, and c) a term including the hematocrit content determined from the at least one secondary output signal, a) terms including individual ratio indices extracted from the analytic output signals, wherein the ratios compare intermediate signal values between separate pulse-signal decay cycles, b) interaction terms between the ratio indices extracted from the analytic output signal, and each of the temperature, secondary output signal and determined analyte concentration of the sample without compensation, and c) a term including the hematocrit content determined from the at least one secondary output signal, wherein the terms are modified by weighing coefficients.