A compound according to Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein: R 1 is hydrogen, halogen, unsubstituted alkyl, substituted alkyl, hydroxylalkyl, heteroalkyl, unsubstituted aryl, substituted aryl, unsubstituted heteroaryl, substituted heteroaryl, ammonioalkyl, alkylammonioalkyl, -O-(unsubstituted alkyl), unsubstituted alkenyl, substituted alkenyl, or unsubstituted phenyl; and R 2 is hydrogen, hydroxyl, -O-(unsubstituted alkyl), -O-(unsubstituted alkyl)-(unsubstituted or substituted aryl), -O-(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl), ammonioalkyl, alkylammonioalkyl, -OC -(unsubstituted or substituted alkyl), -OC -(unsubstituted or substituted cycloalkyl), -OC -(unsubstituted or substituted heterocycloalkyl), -OC -(unsubstituted or substituted aryl), -OC -(unsubstituted or substituted heteroaryl), -OC -(unsubstituted alkyl)-(unsubstituted or substituted aryl), -OC -(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl), -OC -(unsubstituted or substituted aryl)-O-(unsubstituted or substituted aryl), -OC NH-(unsubstituted or substituted aryl), -OC C R 101 R 102 R 103, -OC NH-(unsubstituted or substituted heteroaryl), -OC NH-(unsubstituted alkyl)-(unsubstituted or substituted aryl), -OC NH-(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl),-OSO 3 H, -OS 2 -(unsubstituted alkyl), -OS 2 -(unsubstituted or substituted aryl), -OS 2 -(unsubstituted or substituted heteroaryl), -OS 2 NH 2, -OS 2 O-(unsubstituted alkyl), -OC -(unsubstituted or substituted aryl)-S 2 -(unsubstituted alkyl), -OS 2 NH 2, or -OC -(unsubstituted or substituted aryl)-S 2 -(unsubstituted alkyl); or R 1 and R 2, together with the two carbon atoms to which they are attached, combine to form a six to ten-membered, unsubstituted carbocyclic ring; R 3 is hydrogen or -C N R 4 R 5; each of R 4 and R 5 is independently hydrogen, unsubstituted alkyl, or substituted alkyl; R 101 is hydrogen or unsubstituted alkyl; and R 102 and R 103 are each independently unsubstituted aryl, substituted aryl, unsubstituted heteroaryl, or substituted heteroaryl; with the proviso that at least one of R 1 and R 2 is not hydrogen; with the proviso that when R 1 is hydrogen and R 2 is hydroxyl, then R 3 is other than hydrogen, -C NH 2, -C NHOH, and -C NH(CH 2) 13 CH 3; and with the proviso that when R 1 is propyl or methyl and R 2 is hydroxyl or -OSO 3 H, then at least one of R 4 and R 5 is unsubstituted or substituted alkyl; and with the proviso that when R 1 is hydrogen and R 2 is -OSO 3 H, then R 3 is -C N R 4 R 5 and R 4 is hydrogen and R 5 is alkyl, or R 4 is alkyl and R 5 is alkyl other than methyl. R 1 is hydrogen, halogen, unsubstituted alkyl, substituted alkyl, hydroxylalkyl, heteroalkyl, unsubstituted aryl, substituted aryl, unsubstituted heteroaryl, substituted heteroaryl, ammonioalkyl, alkylammonioalkyl, -O-(unsubstituted alkyl), unsubstituted alkenyl, substituted alkenyl, or unsubstituted phenyl; and R 2 is hydrogen, hydroxyl, -O-(unsubstituted alkyl), -O-(unsubstituted alkyl)-(unsubstituted or substituted aryl), -O-(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl), ammonioalkyl, alkylammonioalkyl, -OC -(unsubstituted or substituted alkyl), -OC -(unsubstituted or substituted cycloalkyl), -OC -(unsubstituted or substituted heterocycloalkyl), -OC -(unsubstituted or substituted aryl), -OC -(unsubstituted or substituted heteroaryl), -OC -(unsubstituted alkyl)-(unsubstituted or substituted aryl), -OC -(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl), -OC -(unsubstituted or substituted aryl)-O-(unsubstituted or substituted aryl), -OC NH-(unsubstituted or substituted aryl), -OC C R 101 R 102 R 103, -OC NH-(unsubstituted or substituted heteroaryl), -OC NH-(unsubstituted alkyl)-(unsubstituted or substituted aryl), -OC NH-(unsubstituted alkyl)-(unsubstituted or substituted heteroaryl),-OSO 3 H, -OS 2 -(unsubstituted alkyl), -OS 2 -(unsubstituted or substituted aryl), -OS 2 -(unsubstituted or substituted heteroaryl), -OS 2 NH 2, -OS 2 O-(unsubstituted alkyl), -OC -(unsubstituted or substituted aryl)-S 2 -(unsubstituted alkyl), -OS 2 NH 2, or -OC -(unsubstituted or substituted aryl)-S 2 -(unsubstituted alkyl); or R 1 and R 2, together with the two carbon atoms to which they are attached, combine to form a six to ten-membered, unsubstituted carbocyclic ring; R 3 is hydrogen or -C N R 4 R 5; each of R 4 and R 5 is independently hydrogen, unsubstituted alkyl, or substituted alkyl; R 101 is hydrogen or unsubstituted alkyl; and R 102 and R 103 are each independently unsubstituted aryl, substituted aryl, unsubstituted heteroaryl, or substituted heteroaryl; with the proviso that at least one of R 1 and R 2 is not hydrogen; with the proviso that when R 1 is hydrogen and R 2 is hydroxyl, then R 3 is other than hydrogen, -C NH 2, -C NHOH, and -C NH(CH 2) 13 CH 3; and with the proviso that when R 1 is propyl or methyl and R 2 is hydroxyl or -OSO 3 H, then at least one of R 4 and R 5 is unsubstituted or substituted alkyl; and with the proviso that when R 1 is hydrogen and R 2 is -OSO 3 H, then R 3 is -C N R 4 R 5 and R 4 is hydrogen and R 5 is alkyl, or R 4 is alkyl and R 5 is alkyl other than methyl.