A nerve stimulation system comprising: at least one nerve interface device comprising: at least one cuff portion (5, 7) having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first (25, 29) and second (27, 31) rings of electrodes mounted on the at least one cuff portion, each ring of electrodes comprising a plurality of electrodes, and wherein each electrode (15a, 17a) in the first ring has a corresponding longitudinally-aligned electrode (15b, 17b) in the second ring so as to form a plurality of pairs of electrodes (15, 17) spaced apart from each other along the longitudinal axis; wherein the plurality of pairs of electrodes includes at least a first pair of electrodes and a second pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion at a different circumferential position to the second pair of electrodes; a stimulation device in electrical communication with the first and second pairs of electrodes and configured to generate first and second electrical signals, the first electrical signal being different from the second electrical signal with respect to at least one signal parameter; and a control system configured to cause the stimulation device to deliver the first electrical signal to the first pair of electrodes for causing a first physiological response and to deliver the second electrical signal to the second pair of electrodes for causing a second physiological response that is different from the first physiological response. at least one nerve interface device comprising: at least one cuff portion (5, 7) having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first (25, 29) and second (27, 31) rings of electrodes mounted on the at least one cuff portion, each ring of electrodes comprising a plurality of electrodes, and wherein each electrode (15a, 17a) in the first ring has a corresponding longitudinally-aligned electrode (15b, 17b) in the second ring so as to form a plurality of pairs of electrodes (15, 17) spaced apart from each other along the longitudinal axis; at least one cuff portion (5, 7) having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first (25, 29) and second (27, 31) rings of electrodes mounted on the at least one cuff portion, each ring of electrodes comprising a plurality of electrodes, and wherein each electrode (15a, 17a) in the first ring has a corresponding longitudinally-aligned electrode (15b, 17b) in the second ring so as to form a plurality of pairs of electrodes (15, 17) spaced apart from each other along the longitudinal axis; wherein the plurality of pairs of electrodes includes at least a first pair of electrodes and a second pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion at a different circumferential position to the second pair of electrodes; a stimulation device in electrical communication with the first and second pairs of electrodes and configured to generate first and second electrical signals, the first electrical signal being different from the second electrical signal with respect to at least one signal parameter; and a control system configured to cause the stimulation device to deliver the first electrical signal to the first pair of electrodes for causing a first physiological response and to deliver the second electrical signal to the second pair of electrodes for causing a second physiological response that is different from the first physiological response.