A medical device for sealing a defect (1740, 1742) or structure in tissue, the medical device comprising: a wire frame that includes a plurality of wound wires that each extend from a proximal end of the wire frame to a distal end of the wire frame, the wires forming: a first eyelet being a wire aggregation element near the proximal end of the wire frame formed from wound first end portions of each wire of the plurality of wires; a second eyelet being a wire aggregation element near the distal end of the wire frame formed from wound second end portions of each wire of the plurality of wires; a sealing member in contact with the frame; characterized in that said medical device further comprises: a first occluding member including a first linear segment and a first curved segment of each wire which together define a petal, said first occluding member having a maximum nominal outer diameter from 27 mm to 48 mm; a second occluding member including a second linear segment and a second curved segment of each wire which together define a petal, said second occluding member having a maximum nominal outer diameter from 27 mm to 48 mm; a defect-occupying portion disposed between the first occluding member and the second occluding member, wherein the defect-occupying portion is adapted to fill a range of defect sizes from a largest defect size to a smallest defect size that is approximately 60% of the largest defect size, the defect-occupying portion comprising a maximum nominal diameter from 17 mm to 36 mm and the defect-occupying portion including a third linear segment of each wire, a fourth linear segment of each wire, and a third curved segment of each wire disposed between the third linear segment and the fourth linear segment of each wire of the plurality of wires; a retrieval cord adapted to retrieve said device, and a non-metal attachment member for said retrieval cord, wherein said non-metal attachment member is an ePTFE closed loop attached to an eyelet of the device. a first eyelet being a wire aggregation element near the proximal end of the wire frame formed from wound first end portions of each wire of the plurality of wires; a second eyelet being a wire aggregation element near the distal end of the wire frame formed from wound second end portions of each wire of the plurality of wires; a sealing member in contact with the frame; a first occluding member including a first linear segment and a first curved segment of each wire which together define a petal, said first occluding member having a maximum nominal outer diameter from 27 mm to 48 mm; a second occluding member including a second linear segment and a second curved segment of each wire which together define a petal, said second occluding member having a maximum nominal outer diameter from 27 mm to 48 mm; a defect-occupying portion disposed between the first occluding member and the second occluding member, wherein the defect-occupying portion is adapted to fill a range of defect sizes from a largest defect size to a smallest defect size that is approximately 60% of the largest defect size, the defect-occupying portion comprising a maximum nominal diameter from 17 mm to 36 mm and the defect-occupying portion including a third linear segment of each wire, a fourth linear segment of each wire, and a third curved segment of each wire disposed between the third linear segment and the fourth linear segment of each wire of the plurality of wires; a retrieval cord adapted to retrieve said device, and a non-metal attachment member for said retrieval cord, wherein said non-metal attachment member is an ePTFE closed loop attached to an eyelet of the device.