mhurhangee/ep-ind-claims huggingface dataset:
A method for selecting a recombinant stable transfected mammalian cell comprising the following steps: a) transfecting a mammalian cell with an expression vector comprising - a first expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody light chain, a bGH polyA signal sequence, and a hGT terminator sequence, - a second expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody heavy chain, a bGH polyA signal sequence, and a hGT terminator sequence, whereby the first expression cassette and the second expression cassette are arranged unidirectional, and thereby obtaining a multitude of recombinant mammalian cells, b) selecting from the multitude of recombinant mammalian cells a (single) stable transfected recombinant mammalian cell, wherein in cell lines obtained by transfection and selection of stable cell clones the combination of bovine growth hormone polyA signal sequence and human gastrin terminator results in an improved antibody expression yield. a) transfecting a mammalian cell with an expression vector comprising - a first expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody light chain, a bGH polyA signal sequence, and a hGT terminator sequence, - a second expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody heavy chain, a bGH polyA signal sequence, and a hGT terminator sequence, whereby the first expression cassette and the second expression cassette are arranged unidirectional, and thereby obtaining a multitude of recombinant mammalian cells, - a first expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody light chain, a bGH polyA signal sequence, and a hGT terminator sequence, - a second expression cassette comprising in 5' to 3' direction a hCMV promoter, a nucleic acid encoding an antibody heavy chain, a bGH polyA signal sequence, and a hGT terminator sequence, whereby the first expression cassette and the second expression cassette are arranged unidirectional, and thereby obtaining a multitude of recombinant mammalian cells, b) selecting from the multitude of recombinant mammalian cells a (single) stable transfected recombinant mammalian cell, wherein in cell lines obtained by transfection and selection of stable cell clones the combination of bovine growth hormone polyA signal sequence and human gastrin terminator results in an improved antibody expression yield.
A composition comprising: a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt% of propylene monomer units and at most 10 wt% of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms, an elastomer of ethylene and an α-olefin comonomer having 4 to 10 carbon atoms, wherein the elastomer has a density of 0.850 to 0.865 g/cm 3 and a melt flow index of 0.1 to 20 dg/min measured in accordance with ASTM D1238 using a 2.16 kg weight and at a temperature of 190 °C and a block copolymer comprising a terminal block comprising styrene or alpha-methylstyrene. a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt% of propylene monomer units and at most 10 wt% of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms, an elastomer of ethylene and an α-olefin comonomer having 4 to 10 carbon atoms, wherein the elastomer has a density of 0.850 to 0.865 g/cm 3 and a melt flow index of 0.1 to 20 dg/min measured in accordance with ASTM D1238 using a 2.16 kg weight and at a temperature of 190 °C and a block copolymer comprising a terminal block comprising styrene or alpha-methylstyrene.
A fluid transport dressing for a negative pressure wound treatment system, said fluid transport dressing comprising a plurality of sealed chambers comprising chamber fluid, characterized in that said fluid transport dressing further comprises a top sheet and a bottom sheet, at least one fluid conduit being provided between said sealed chambers, said top sheet and said bottom sheet.
A quality of service QoS control method, comprising: receiving, by a terminal, service data flow-level, SDF-level, QoS control information from a session management function entity, wherein the SDF-level QoS control information comprises one or more QoS rules, each QoS rule is corresponding to an SDF and the each QoS rule comprises: a QoS rule identifier, one or more SDF-level packet filters corresponding to the SDF, a SDF-level priority corresponding to the SDF, and a QoS flow identifier; and sending, by the terminal, an uplink data packet based on the SDF-level QoS control information, wherein the sending, by the terminal, an uplink data packet based on the SDF-level QoS control information comprises: determining a matching order of SDF-level packet filters in the one or more QoS rules based on SDF-level priorities in the one or more QoS rules; performing matching between the uplink data packet and the SDF-level packet filters based on the matching order of the SDF-level packet filters, and transmitting the uplink data packet using a QoS flow corresponding to a SDF-level packet filter that successfully matches the uplink data packet. receiving, by a terminal, service data flow-level, SDF-level, QoS control information from a session management function entity, wherein the SDF-level QoS control information comprises one or more QoS rules, each QoS rule is corresponding to an SDF and the each QoS rule comprises: a QoS rule identifier, one or more SDF-level packet filters corresponding to the SDF, a SDF-level priority corresponding to the SDF, and a QoS flow identifier; and sending, by the terminal, an uplink data packet based on the SDF-level QoS control information, wherein the sending, by the terminal, an uplink data packet based on the SDF-level QoS control information comprises: determining a matching order of SDF-level packet filters in the one or more QoS rules based on SDF-level priorities in the one or more QoS rules; performing matching between the uplink data packet and the SDF-level packet filters based on the matching order of the SDF-level packet filters, and transmitting the uplink data packet using a QoS flow corresponding to a SDF-level packet filter that successfully matches the uplink data packet. determining a matching order of SDF-level packet filters in the one or more QoS rules based on SDF-level priorities in the one or more QoS rules; performing matching between the uplink data packet and the SDF-level packet filters based on the matching order of the SDF-level packet filters, and transmitting the uplink data packet using a QoS flow corresponding to a SDF-level packet filter that successfully matches the uplink data packet.
A method for controllably reducing the flow area of a turbine nozzle component, the method comprising: obtaining a turbine nozzle component having inner endwall inter-blade flow areas, outer endwall inter-blade flow areas, and a plurality of turbine nozzle flow paths bounded by the inner and outer endwall inter-blade flow areas; positioning braze preforms in the plurality of turbine nozzle flow paths and against a surface of the turbine nozzle component; and bonding the braze preforms to the turbine nozzle component to achieve a controlled reduction in the flow area of the turbine nozzle flow paths; characterized in that the method further comprises: cutting pieces of braze tape to have planform geometries substantially conformal to the inner endwall inter-blade flow areas or the outer endwall inter-blade flow areas; and sintering the pieces of braze tape to produce the braze preforms. obtaining a turbine nozzle component having inner endwall inter-blade flow areas, outer endwall inter-blade flow areas, and a plurality of turbine nozzle flow paths bounded by the inner and outer endwall inter-blade flow areas; positioning braze preforms in the plurality of turbine nozzle flow paths and against a surface of the turbine nozzle component; and bonding the braze preforms to the turbine nozzle component to achieve a controlled reduction in the flow area of the turbine nozzle flow paths; characterized in that the method further comprises: cutting pieces of braze tape to have planform geometries substantially conformal to the inner endwall inter-blade flow areas or the outer endwall inter-blade flow areas; and sintering the pieces of braze tape to produce the braze preforms. cutting pieces of braze tape to have planform geometries substantially conformal to the inner endwall inter-blade flow areas or the outer endwall inter-blade flow areas; and sintering the pieces of braze tape to produce the braze preforms.
Lighting device of the suspension type, comprising: - a cable, tensioned, suitable for anchoring to a ceiling; - a body, sliding along the cable; - an optical group; - a positioning system provided inside the body, comprising a plurality of pulleys (61, 81) which define a path for the cable, a path which triggers a system of forces suitable for keeping the body at the desired height; characterized in that the optical group is engaged to the body. - a cable, tensioned, suitable for anchoring to a ceiling; - a body, sliding along the cable; - an optical group; - a positioning system provided inside the body, comprising a plurality of pulleys (61, 81) which define a path for the cable, a path which triggers a system of forces suitable for keeping the body at the desired height; characterized in that the optical group is engaged to the body.
A magnetic composition containing a metal-salen complex compound, for use in a method of treatment, the method comprising locally applying the composition to an affected tissue of a living body, and retaining the composition in the affected tissue with an external magnetic field; the metal-salen complex compound having a crystal grain diameter as measured with transmission electron microscopy of 1 μm or more and 8μm or less, wherein the percentage of the metal-salen complex compound with a crystal grain diameter of 1 μm or more to 3 μm or less is 70% or more; the metal-salen complex compound containing a compound of Structural Formula below. N,N'-Bis(salicylidene)ethylenediamine metal M is Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd.
A socket assembly comprising a socket element having an aperture for receiving a plug, wherein the socket assembly further comprises a flexible, resilient member, the socket element being fixed at a first end thereof such that said aperture is accessible, wherein the flexible, resilient member has the form of an elongated cylinder and is hollow at the first end thereof, and characterised in that the socket assembly further comprises a spigot, wherein the socket element is retained within said first end, wherein the second end of the flexible, resilient member is hollow and fits over and is retained by the spigot.
A boat comprising a bottom bordered radially outwards by a wall which comprises an inflatable and foldable front wall, an inflatable and foldable side wall, and a rear wall, said boat includes at least one inflatable and foldable longitudinal support parallel to said side wall, said support comprising an inflatable flange and an upper connection extending longitudinally along said side wall and forming in use a flat surface capable of receiving an element, said flange has a cylindrical shape with a circular section, said upper connection is foldable, said boat being characterised in that said upper connection directly connects said flange with the upper portion of said side wall.
A charged particle beam device for inspecting a specimen, comprising a charged particle beam source adapted to generate a primary charged particle beam and an objective lens device (40, 45) adapted to direct the primary charged particle beam onto the specimen; a retarding field device (46, 47) adapted to accelerate secondary charged particles starting from the specimen, wherein a first group of the secondary charged particles comprises secondary charged particles starting from the specimen with high starting angles, and a second group of the secondary charged particles comprises secondary charged particles starting from the specimen with low starting angles; a first detector device having a circular shape, comprising at least two detector segments for detecting secondary particles, a central opening, wherein the central opening is configured for letting pass the primary charged particle beam coming from the charged particle beam source and for letting pass the first group of the secondary charged particles; wherein the objective lens device (40, 45) is adapted such that particles with different arbitrary starting angles from the specimen exhibit crossovers at substantially the same distance from the specimen, forming a common crossover, and a first aperture located between the objective lens and the detector, having an opening with a diameter equal to or smaller than the central opening in the detector device, and which is provided in a position which fulfills at least one of the following properties: (i) it is in the vicinity of the common crossover, (ii) it is at a position in the vicinity of the magnetic lens gap in an area of the maximum spread of stray electrons. at least two detector segments for detecting secondary particles, a central opening, wherein the central opening is configured for letting pass the primary charged particle beam coming from the charged particle beam source and for letting pass the first group of the secondary charged particles; (i) it is in the vicinity of the common crossover, (ii) it is at a position in the vicinity of the magnetic lens gap in an area of the maximum spread of stray electrons.
A composite fibre panel having a core comprising: between 20% and 70% by weight of mineral fibres; and between 30% and 80% by weight of polymeric material; and in which the polymeric material comprises (i) polymeric material in particulate form selected from the group consisting of, rubber(s), natural rubber(s), synthetic rubber(s), polyurethane, elastomer(s) and mixtures thereof and (ii) polymeric material in the form of a foam. between 20% and 70% by weight of mineral fibres; and between 30% and 80% by weight of polymeric material; and in which the polymeric material comprises (i) polymeric material in particulate form selected from the group consisting of, rubber(s), natural rubber(s), synthetic rubber(s), polyurethane, elastomer(s) and mixtures thereof and (ii) polymeric material in the form of a foam.
A method for removing sterilant molecules from a carrier gas, said method comprising the steps of: applying an electrical charge to an electrode located in an internal cavity of a housing, said electrode formed of a material that is (i) chemically active with respect to molecules of a sterilant to destroy or react with said molecules, and (ii) conductive to electricity, said material selected from the group comprising: glass frits, copper, a precious metal, a transition metal, and transition metal oxides, wherein said charged electrode forms a non-uniform electric field in a region of space surrounding said electrode to force said sterilant molecules toward said electrode; and flowing the carrier gas through the internal cavity, wherein said non-uniform electric field forces said sterilant molecules toward said electrode. applying an electrical charge to an electrode located in an internal cavity of a housing, said electrode formed of a material that is (i) chemically active with respect to molecules of a sterilant to destroy or react with said molecules, and (ii) conductive to electricity, said material selected from the group comprising: glass frits, copper, a precious metal, a transition metal, and transition metal oxides, wherein said charged electrode forms a non-uniform electric field in a region of space surrounding said electrode to force said sterilant molecules toward said electrode; and flowing the carrier gas through the internal cavity, wherein said non-uniform electric field forces said sterilant molecules toward said electrode.
Use of a kit in in vitro detection or diagnosis of lung cancer in a sample from a subject, wherein the kit comprises a nucleic acid(s) capable of specifically binding to a polynucleotide of lung cancer marker: miR-2467-3p, or to a polynucleotide consisting of a nucleotide sequence complementary to that of the polynucleotide.
An artificial graphite material A, wherein the artificial graphite material A is secondary particles, and a surface roughness η A of the artificial graphite material A satisfies 6≤η A ≤12.
Filling unit for filling cavities in a tablet press with a feedstock to be pressed, particularly a powder, having a filling assembly comprising a fill chamber, wherein the fill chamber is arranged in an installed condition between a die containing the cavities and a punch support comprising at least one punch (9, 10), and wherein the fill chamber has at least one inlet opening for filling the fill chamber with raw materials and at least one outlet opening for filling the cavities of the tablet press with feedstock to be pressed, wherein the fill chamber comprises at least one mixing unit arranged in the fill chamber, for mixing the raw material of the feedstock to be pressed and at least one delivery unit for filling the cavities of the tablet press with feedstock to be pressed, characterized in that the mixing unit for mixing the raw materials and the delivery unit for filling the cavities of the tablet press with feedstock to be pressed lie in a horizontal plane.
A radio remote unit, RRU, comprising at least one receive channel pair, a first local oscillator module, a second local oscillator module, a local oscillator switching switch, and a controller, wherein each receive channel pair comprises a first receive channel and a second receive channel, the first receive channel is connected to the first local oscillator module, the second receive channel is connected to the first local oscillator module and the second local oscillator module by using the local oscillator switching switch, and the controller is connected to the second local oscillator module and the local oscillator switching switch; each receive channel in each receive channel pair comprises a filtering module, a frequency mixing module connected to the filtering module, and a digital processing module connected to the frequency mixing module, wherein a frequency mixing module on the first receive channel is connected to the first local oscillator module, and a frequency mixing module on the second receive channel is connected to the first local oscillator module and the second local oscillator module by using the local oscillator switching switch; and the controller is configured to: receive an operating mode that is sent by a base station; and if the operating mode is an intra-frequency mode, control the local oscillator switching switch to perform switching, so that the frequency mixing module on the second receive channel is connected to the first local oscillator module; or if the operating mode is an inter-frequency mode, control the local oscillator switching switch to perform switching, so that the frequency mixing module on the second receive channel is connected to the second local oscillator module, and configure a frequency of a local oscillator signal output by the second local oscillator module as a local oscillator frequency indicated by the inter-frequency mode.
A portable, insulated food container comprising: a vacuum insulated removable outer cover; a vacuum insulated base; a vacuum insulated base carrier; one or more non-insulated container(s): one or more detachable lid(s); a supporting base; one or more interlocking units [7,8]; wherein the vacuum insulated removable outer cover comprises one or more grips [1,2]; wherein the interlocking unit comprises of one or more latches on the side walls of the vacuum insulated base carrier and one or more knobs/ locking pins on the side walls of the vacuum insulated removable outer cover, wherein, the vacuum insulated base carrier and the vacuum insulated base is a unitary system, wherein an activated getter pill is used to maintain a high vacuum in the unitary system and the vacuum insulated base carrier is configured to receive the vacuum insulated removable outer cover which snug fits on the vacuum insulated base carrier at the insulated base about the outer rim of the vacuum insulated base carrier. a vacuum insulated removable outer cover; a vacuum insulated base; a vacuum insulated base carrier; one or more non-insulated container(s): one or more detachable lid(s); a supporting base; one or more interlocking units [7,8]; one or more detachable lid(s); a supporting base; one or more interlocking units [7,8]; wherein the vacuum insulated removable outer cover comprises one or more grips [1,2]; wherein the interlocking unit comprises of one or more latches on the side walls of the vacuum insulated base carrier and one or more knobs/ locking pins on the side walls of the vacuum insulated removable outer cover, wherein, the vacuum insulated base carrier and the vacuum insulated base is a unitary system, wherein an activated getter pill is used to maintain a high vacuum in the unitary system and the vacuum insulated base carrier is configured to receive the vacuum insulated removable outer cover which snug fits on the vacuum insulated base carrier at the insulated base about the outer rim of the vacuum insulated base carrier.
A computer implemented method of a home network access point for secure network access by a mobile computing device, the mobile device being associated with the home network access point by a digitally signed original record in a blockchain indicating that network access is provided by the home network access point wherein the blockchain is accessible via a network and includes a plurality of records validated by miner computing components, the method comprising: receiving a request from an away network access point to associate the mobile device with the away network access point in order to provide network access via the away network access point, the request having associated identification information for the mobile device; responsive to a verification of an entitlement of the mobile device to access the network based on the identification information for the mobile device, generating a new record for storage in the blockchain, the new record associating the mobile device with the away network access point and providing the new record to the miner computing components for validation and eventual commitment to the blockchain wherein the new record indicates that the away network access point provides access to the network for the mobile device based on the validation of the new record, wherein the new record supersedes the original record of association for the mobile device with the home network access point such that network access is provided to the mobile device exclusively by the away network access point. receiving a request from an away network access point to associate the mobile device with the away network access point in order to provide network access via the away network access point, the request having associated identification information for the mobile device; responsive to a verification of an entitlement of the mobile device to access the network based on the identification information for the mobile device, generating a new record for storage in the blockchain, the new record associating the mobile device with the away network access point and providing the new record to the miner computing components for validation and eventual commitment to the blockchain wherein the new record indicates that the away network access point provides access to the network for the mobile device based on the validation of the new record, wherein the new record supersedes the original record of association for the mobile device with the home network access point such that network access is provided to the mobile device exclusively by the away network access point.