An ostomy waste matter collection device comprising an ostomy connection tube adapted to be fixed in an ostomy, a discharge valve disposed in the ostomy connection tube and used for controlling discharge of a waste matter, a sealing member disposed between the ostomy connection tube and an abdominal wall, in use, for sealing, a turning outward line disposed between the discharge valve and the sealing member, and an ostomy protection assembly for covering the ostomy exposed outside the abdominal wall and being connected with the ostomy connection tube, characterised in that the discharge valve comprises a multi-cavity inflatable bag disposed in the ostomy connection tube and a first inflatable connection tube connected with the multi-cavity inflatable bag, the multi-cavity inflatable bag expandable inwardly to close a cavity of the ostomy connection tube when the multi-cavity inflatable bag is inflated; wherein the sealing member comprises an elastic bag disposed at the ostomy connection tube and a second inflatable connection tube connected with the elastic bag; wherein the ostomy protection assembly comprises a turning horn mouth extended from the ostomy connection tube and used for covering an ostomy exposed portion, and a first sealing ring disposed at an end of the turning horn mouth; wherein a second sealing ring fixed in the ostomy, in use, is disposed at the turning outward line; wherein the turning outward line is a center line when the turning horn mouth with the first sealing ring is turned outward till the elastic bag is aligned with or close to the multi-cavity inflatable bag; wherein the second sealing ring is adapted to open an intestinal wall and be tightly close to the abdominal wall after the second sealing ring enters the ostomy, and the second sealing ring and the elastic ostomy connection tube adapted to cooperate to form a first section sealing; the elastic bag being inflatable through the second inflatable connection tube, and the elastic bag is adapted to be tightly close to the intestinal wall to form a second section sealing; and the first section sealing and the second section being adapted to sealingly cooperate to prevent the waste matter in the intestine from leaking along the intestinal wall. wherein the sealing member comprises an elastic bag disposed at the ostomy connection tube and a second inflatable connection tube connected with the elastic bag; wherein the ostomy protection assembly comprises a turning horn mouth extended from the ostomy connection tube and used for covering an ostomy exposed portion, and a first sealing ring disposed at an end of the turning horn mouth; wherein a second sealing ring fixed in the ostomy, in use, is disposed at the turning outward line; wherein the turning outward line is a center line when the turning horn mouth with the first sealing ring is turned outward till the elastic bag is aligned with or close to the multi-cavity inflatable bag; wherein the second sealing ring is adapted to open an intestinal wall and be tightly close to the abdominal wall after the second sealing ring enters the ostomy, and the second sealing ring and the elastic ostomy connection tube adapted to cooperate to form a first section sealing; the elastic bag being inflatable through the second inflatable connection tube, and the elastic bag is adapted to be tightly close to the intestinal wall to form a second section sealing; and the first section sealing and the second section being adapted to sealingly cooperate to prevent the waste matter in the intestine from leaking along the intestinal wall.