Opioid receptor agonist for use in an opioid detoxification treatment to reduce the concentration of an opioid in the blood plasma of an individual, said detoxification treatment comprising: - providing an initial dosing regimen of the opioid receptor agonist that is the chemical or drug substance causing the physical dependence or a stabilizing concentration of a replacement chemical or drug substance which is an opioid agonist used in conventional therapies for opioid addiction treatment; - titrating an initial peak concentration of the opioid receptor agonist in the blood plasma of the individual for a predefined dosing period; - titrating a lowest concentration level of the opioid receptor agonist in the blood plasma of an individual immediately before the end of the predefined dosing period; and - providing a plurality of subsequent doses of the opioid receptor agonist for a plurality of subsequent dosing periods wherein each subsequent dosing period requires administering a dosing amount of the opioid receptor agonist, and wherein each of the subsequent doses of the opioid receptor agonist is such that the projected lowest concentration level of the opioid receptor agonist in the blood plasma for the subsequent dosing period decreased by not more than five percent of the projected lowest concentration level of the opioid receptor agonist of the previous dosing period and wherein the plurality of dosing periods added together is sixty days or more, said plurality of dosing periods comprising thirty dosing periods or more wherein the each of the subsequent doses of the opioid receptor agonist is based on the projected blood levels of the opioid receptor agonist as determined by the pharmacokinetic profile of the opioid receptor agonist. - providing an initial dosing regimen of the opioid receptor agonist that is the chemical or drug substance causing the physical dependence or a stabilizing concentration of a replacement chemical or drug substance which is an opioid agonist used in conventional therapies for opioid addiction treatment; - titrating an initial peak concentration of the opioid receptor agonist in the blood plasma of the individual for a predefined dosing period; - titrating a lowest concentration level of the opioid receptor agonist in the blood plasma of an individual immediately before the end of the predefined dosing period; and - providing a plurality of subsequent doses of the opioid receptor agonist for a plurality of subsequent dosing periods wherein each subsequent dosing period requires administering a dosing amount of the opioid receptor agonist, and wherein each of the subsequent doses of the opioid receptor agonist is such that the projected lowest concentration level of the opioid receptor agonist in the blood plasma for the subsequent dosing period decreased by not more than five percent of the projected lowest concentration level of the opioid receptor agonist of the previous dosing period and wherein the plurality of dosing periods added together is sixty days or more, said plurality of dosing periods comprising thirty dosing periods or more wherein the each of the subsequent doses of the opioid receptor agonist is based on the projected blood levels of the opioid receptor agonist as determined by the pharmacokinetic profile of the opioid receptor agonist.