mhurhangee/ep-ind-claims huggingface dataset:
A combined pharmaceutical composition comprising: a) a conjugate comprising (i) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof having at least 10% of the activity of human IL-15 on the proliferation induction of kit225 cell line, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof having at least 10% of the binding activity of the sushi domain of human IL-15Rα to human IL-15, a polynucleotide coding therefore, or a vector comprising such a polynucleotide; and b) an antibody antagonizing an immune pathway implicated in the inhibition of T cell activation, or a fragment thereof capable of reacting with the same antigen than its antibody counterpart, a polynucleotide coding therefore, or a vector comprising such a polynucleotide, wherein said antibody is a PD-1/PD-L1/PD-L2 antagonist, wherein said antibody is antagonizing either by binding the PD-1 receptor or by binding the PD-L1 or PD-L2 ligand; wherein said conjugate and the antibody or fragment thereof are not linked. a) a conjugate comprising (i) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof having at least 10% of the activity of human IL-15 on the proliferation induction of kit225 cell line, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof having at least 10% of the binding activity of the sushi domain of human IL-15Rα to human IL-15, a polynucleotide coding therefore, or a vector comprising such a polynucleotide; and b) an antibody antagonizing an immune pathway implicated in the inhibition of T cell activation, or a fragment thereof capable of reacting with the same antigen than its antibody counterpart, a polynucleotide coding therefore, or a vector comprising such a polynucleotide, wherein said antibody is a PD-1/PD-L1/PD-L2 antagonist, wherein said antibody is antagonizing either by binding the PD-1 receptor or by binding the PD-L1 or PD-L2 ligand;
A packaging plant comprising: - at least one manufacturing machine configured for manufacturing at least one flow of products, - at least one large distribution packaging unit configured for receiving said at least one flow of products from said manufacturing machine and for packaging said products in a large distribution packaging format, - at least one draw-off unit associated to said at least one manufacturing machine and configured for drawing-off products intended to be distributed through e-commerce distribution channels from said at least one flow of products, - a filling station located downstream of said draw-off unit, - a plurality of transfer containers movable independently of each other along at least one stationary guide system and configured for receiving said products intended to be distributed through e-commerce distribution channels at said filling station, - a stocking area wherein a plurality of said transfer containers are stocked, and - a flexible packaging area including at least one packaging robot configured for picking products from transfer containers placed in said flexible packaging area and for placing a variable number of products into packaging containers. - at least one manufacturing machine configured for manufacturing at least one flow of products, - at least one large distribution packaging unit configured for receiving said at least one flow of products from said manufacturing machine and for packaging said products in a large distribution packaging format, - at least one draw-off unit associated to said at least one manufacturing machine and configured for drawing-off products intended to be distributed through e-commerce distribution channels from said at least one flow of products, - a filling station located downstream of said draw-off unit, - a plurality of transfer containers movable independently of each other along at least one stationary guide system and configured for receiving said products intended to be distributed through e-commerce distribution channels at said filling station, - a stocking area wherein a plurality of said transfer containers are stocked, and - a flexible packaging area including at least one packaging robot configured for picking products from transfer containers placed in said flexible packaging area and for placing a variable number of products into packaging containers.
An air vehicle comprising: a fuselage that rolls about a longitudinal axis of the fuselage; and a collar that is positionable relative to the fuselage; wherein the collar includes ailerons the air vehicle being characterised in that: said ailerons are configured to passively change angle of incidence as a function of the velocity of the projectile; wherein aerodynamic forces on the ailerons are balanced against resilient forces on the ailerons; wherein, the resilient forces are provided by springs operatively coupled to the ailerons that provide a spring force, in opposition to a pressure force on the ailerons that tends to reduce the angle of incidence of the ailerons by pivoting the ailerons as the dynamic pressure increases. a fuselage that rolls about a longitudinal axis of the fuselage; and a collar that is positionable relative to the fuselage; wherein the collar includes ailerons the air vehicle being characterised in that: said ailerons are configured to passively change angle of incidence as a function of the velocity of the projectile; said ailerons are configured to passively change angle of incidence as a function of the velocity of the projectile; wherein aerodynamic forces on the ailerons are balanced against resilient forces on the ailerons; wherein, the resilient forces are provided by springs operatively coupled to the ailerons that provide a spring force, in opposition to a pressure force on the ailerons that tends to reduce the angle of incidence of the ailerons by pivoting the ailerons as the dynamic pressure increases.
An ophthalmic measurement system, comprising: a first optical measurement module having a first optical axis, measuring at least a first characteristic of a subject's eye; a second optical measurement module having a second optical axis, measuring at least a second characteristic of a subject's eye, said second optical measurement module being juxtaposed relative to said first optical measurement module; and a base element to which said first and said second optical measurement modules are linked, characterised in that said base element has a rotatable joint aligned such that angular rotation of said joint around its axis enables either of said first and said second optical measurement modules to be disposed in front of said subject's eye. a first optical measurement module having a first optical axis, measuring at least a first characteristic of a subject's eye; a second optical measurement module having a second optical axis, measuring at least a second characteristic of a subject's eye, said second optical measurement module being juxtaposed relative to said first optical measurement module; and a base element to which said first and said second optical measurement modules are linked, characterised in that said base element has a rotatable joint aligned such that angular rotation of said joint around its axis enables either of said first and said second optical measurement modules to be disposed in front of said subject's eye.
Card holding device having at least one guide (42a, 42b) and having a clamping unit with at least one first clamping element, which clamping unit clamps a card, which is to be held and has two mutually opposite flat faces (6, 7), on one flat face in a manner controlled by the at least one guide (42a, 42b) when the clamping unit moves in relation to the at least one guide (42a, 42b), in which case the clamping unit has at least one first elastic element with a first region and a second region, which element is guided indirectly or directly at the at least first region by means of the at least one guide (42a, 42b), and clamps the card indirectly or directly by means of the at least one second region, characterized in that the card holding device has an electric motor drive and the inward movement of the card can be driven at least partly by means of the drive, at least one clamping element is rotatably mounted about a rotation axis, and the card, which is to be held, can be clamped in the manner of tongs by means of the clamping elements (4, 11).
Compound of general Formula: wherein: n: 1-5 m: 0, 1, or 2 z: 0 or 1 L: =CH 2 -, =CH 2 CH 2 - or A: is wherein R 1: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 2: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 3: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 4: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 5: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, or a pharmaceutically acceptable salt, hydrate or solvate thereof; in the form of a pure diastereoisomer or as a mixture of diastereomers, in the form of a pure enantiomer or as a mixture of enantiomers. n: 1-5 m: 0, 1, or 2 z: 0 or 1 L: =CH 2 -, =CH 2 CH 2 - or A: is wherein R 1: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 2: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 3: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 6: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu, or i-Bu, R 4: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 5: H, Me, Et, i-Pr, t-Bu, i-Bu, CN, F, Cl, Br, CF 3, CH 2 CF 2, cyclopropyl, cyclobutyl, cyclopentyl, SR 6, OR 6 or NR 6 R 7 R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, or a pharmaceutically acceptable salt, hydrate or solvate thereof; in the form of a pure diastereoisomer or as a mixture of diastereomers, in the form of a pure enantiomer or as a mixture of enantiomers. R 6: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu, R 7: H, Me, Et, n-Pr, i-Pr, t-Bu or i-Bu,
A method of operating a first display device, the method comprising: displaying a first image (810, 1210) of a first content acquired by the first display device, wherein the first image includes a target object; receiving an input of selecting the target object from among one or more objects included in the first image (810, 1210); acquiring information on a first coordinate of the target object, the information on the first coordinate including coordinate values (x, y, z, w, h) of a region of the first image (810, 1210) in which the target object is located; transmitting the information on the first coordinate to a second display device; acquiring a second image of the first content, wherein the second image is acquired temporally later than the first image (810, 1210), and transmitting the second image to the second display device; receiving, from the second display device, information on a second coordinate of the target object included in the second image, the information on the second coordinate including coordinate values (X, Y, Z, W, H) of a region of the second image in which the target object is located; based on the information on the second coordinate, acquiring, from the second image, an image tracking the target object, wherein the image tracking the target object corresponds to an image which includes an image of the region of the second image corresponding to the second coordinate; and displaying, on the first display device, the acquired image tracking the target object. displaying a first image (810, 1210) of a first content acquired by the first display device, wherein the first image includes a target object; receiving an input of selecting the target object from among one or more objects included in the first image (810, 1210); acquiring information on a first coordinate of the target object, the information on the first coordinate including coordinate values (x, y, z, w, h) of a region of the first image (810, 1210) in which the target object is located; transmitting the information on the first coordinate to a second display device; acquiring a second image of the first content, wherein the second image is acquired temporally later than the first image (810, 1210), and transmitting the second image to the second display device; receiving, from the second display device, information on a second coordinate of the target object included in the second image, the information on the second coordinate including coordinate values (X, Y, Z, W, H) of a region of the second image in which the target object is located; based on the information on the second coordinate, acquiring, from the second image, an image tracking the target object, wherein the image tracking the target object corresponds to an image which includes an image of the region of the second image corresponding to the second coordinate; and displaying, on the first display device, the acquired image tracking the target object.
A food processing device (100, 200), comprising: - a jar configured to contain food, - a base unit configured to support and accommodate the jar, - a vacuum mechanism configured to suck air from the jar, comprising a vacuum pump arranged in the base unit and a first vacuum conduit extending through the base unit and being coupled to the vacuum pump, and - a lid configured to cover the jar and to realize air communication between the jar and the base unit, wherein the vacuum mechanism further comprises a second vacuum conduit extending through the lid, wherein the first vacuum conduit and the second vacuum conduit are engageable to each other through respective engaging ends (34, 35) thereof, wherein at least one of the engaging ends (34, 35) of the first vacuum conduit and the second vacuum conduit is displaceable between an outward position and a retracted position in the respective one of the base unit and the lid, characterized in that the first vacuum conduit and the second vacuum conduit are engaged to each other when the at least one of the engaging ends (34, 35) of the first vacuum conduit and the second vacuum conduit is at the outward position in the respective one of the base unit and the lid, and in that the first vacuum conduit and the second vacuum conduit are disengaged from each other when the at least one of the engaging ends (34, 35) of the first vacuum conduit and the second vacuum conduit is at the retracted position in the respective one of the base unit and the lid, and in that the food processing device (100, 200) comprises a driven actuator configured to displace the at least one of the engaging ends (34, 35) of the first vacuum conduit and the second vacuum conduit in the respective one of the base unit and the lid to the outward position, and in that at least one resilient member is configured to bias the at least one of the engaging ends (34, 35) of the first vacuum conduit and the second vacuum conduit in the respective one of the base unit and the lid to the retracted position. - a jar configured to contain food, - a base unit configured to support and accommodate the jar, - a vacuum mechanism configured to suck air from the jar, comprising a vacuum pump arranged in the base unit and a first vacuum conduit extending through the base unit and being coupled to the vacuum pump, and - a lid configured to cover the jar and to realize air communication between the jar and the base unit,
Axle connection for a sprung vehicle axle, having a preferably tubular axle beam, axle guides which cross the axle beam on its upper or underside, an axle plate which is arranged between the axle beam and the respective axle guide, and tension elements for pulling the axle beam and the axle guide against one another with deformation of the axle plate, the axle plate - being provided on its first side with two bearing locations (A, B) which are spaced apart from one another in the longitudinal direction and at which the axle plate is supported against the axle guide, and which are configured as supporting regions (21, 22) which form a flat "V" in the case of a non-deformed axle plate, - having at least one deformation region between the two bearing locations (A, B), and - being provided on its second side with a mouth with a mouth base and two jaws (11, 12) with inner faces (11A, 12A) which face one another, the inner faces (11A, 12A) being directed against the front and the rear side of the axle beam, characterized in that the axle beam is supported, at least at the beginning of the deformation, exclusively against two pressure faces (31, 32) which are formed on the mouth base and of which the first pressure face is arranged at a spacing in front of, and the second pressure face is arranged at a spacing behind, the mouth center. - being provided on its first side with two bearing locations (A, B) which are spaced apart from one another in the longitudinal direction and at which the axle plate is supported against the axle guide, and which are configured as supporting regions (21, 22) which form a flat "V" in the case of a non-deformed axle plate, - having at least one deformation region between the two bearing locations (A, B), and - being provided on its second side with a mouth with a mouth base and two jaws (11, 12) with inner faces (11A, 12A) which face one another, the inner faces (11A, 12A) being directed against the front and the rear side of the axle beam,
Cryogenic unit comprising: - a cryogenic tank; - a receptacle extending along a longitudinal axis between a first longitudinal side and a second longitudinal side, the receptacle being situated outside the cryogenic tank; - a pipe comprising: - a first end connected to the cryogenic tank so that a cryogenic fluid contained in the cryogenic tank can circulate in the pipe; - a second end situated inside the receptacle; characterized in that the pipe comprises: - a first longitudinal portion situated inside the receptacle and configured to allow the cryogenic fluid to circulate in a first direction travelling from the first end towards the second end; - a second longitudinal portion situated inside the receptacle; - a bend situated inside the receptacle between the first portion and the second portion; - a connecting flange secured to the pipe and situated between the bend and the second end, the connecting flange being situated at a first distance from the second end; and in that the unit comprises: - an item of fluidic equipment comprising an inlet end and an outlet end and configured to be mounted removably inside the receptacle in a mounted position, - the second end being at least partially inserted into the fluidic equipment via the inlet end; - the fluidic equipment being connected to the connecting flange so as to allow the cryogenic fluid to enter the fluidic equipment via the inlet end. - a cryogenic tank; - a receptacle extending along a longitudinal axis between a first longitudinal side and a second longitudinal side, the receptacle being situated outside the cryogenic tank; - a pipe comprising: - a first end connected to the cryogenic tank so that a cryogenic fluid contained in the cryogenic tank can circulate in the pipe; - a second end situated inside the receptacle; characterized in that the pipe comprises: - a first longitudinal portion situated inside the receptacle and configured to allow the cryogenic fluid to circulate in a first direction travelling from the first end towards the second end; - a second longitudinal portion situated inside the receptacle; - a bend situated inside the receptacle between the first portion and the second portion; - a connecting flange secured to the pipe and situated between the bend and the second end, the connecting flange being situated at a first distance from the second end; - an item of fluidic equipment comprising an inlet end and an outlet end and configured to be mounted removably inside the receptacle in a mounted position, - the second end being at least partially inserted into the fluidic equipment via the inlet end; - the fluidic equipment being connected to the connecting flange so as to allow the cryogenic fluid to enter the fluidic equipment via the inlet end.
A method for operating a quantum cascade laser "QCL" element having a pair of electrodes (20,30) and a semiconductor superlattice sandwiched by the pair of electrodes (20,30), wherein the semiconductor superlattice has an active region that emits electromagnetic waves at a frequency in THz range when a voltage is applied between the pair of electrodes (20,30), wherein the active region has repeating unit structures, each unit structure having a thickness and including sets of well layers (10W1, 10W2, 10W3, 10W4) and barrier layers (10B1, 10B2, 10B3, 10B4) alternatingly laminated with each other, the method comprising a step of applying a voltage for emission of the electromagnetic waves to the semiconductor superlattice at an operating temperature T that satisfies E LO > k B T + E 32, where the E LO denotes energy of a longitudinal optical phonon that can be excited within the materials of the semiconductor superlattice, the E 32 denotes a difference value between minimum energy E 3 of an upper lasing level and minimum energy E 2 of a lower lasing level in the repeating unit structures, the difference corresponding to photon energy of the electromagnetic waves at the frequency, the operating temperature T being measured in unit K from outside of the QCL element while the QCL element is operated at the voltage, and the k B denoting Boltzmann constant, and wherein the unit structure in the semiconductor superlattice is configured such that the lower lasing level and the depopulation level in the repeating unit structures therein satisfy, when the voltage is applied, E 21 ≤ E LO, where the E 21 denotes a difference value between the minimum energy E 2 of the lower lasing level and minimum energy E 1 of the depopulation level, characterised in that the well layers (10W1, 10W2, 10W3, 10W4) are made of Al x Ga 1-x As, where 0<x<1, which is a mixed crystal of AlAs and GaAs.
Rotor assembly for a wind turbine generator, the rotor assembly comprising a number of rotor segments forming a rotor structure, carrying a rotor frame, the rotor frame receiving a plurality of rotor magnets, and a central structure connected to the rotor structure and at least partially arranged between at least two of the rotor segments, characterized in that the central structure comprises a reinforcing element adapted to be attached both to the rotor segments and to a portion of the rotor frame.