A compound of formula I or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula I is a compound of formula I* or a compound of formula II* and wherein at least one of R 2, R 3, R 4, R 20, R 22, R 23 or R 24 independently of each other comprises at least one ONO 2 or ONO moiety; R 1 is C 1 -C 3 alkyl; R 2 is H, C 1 -C 3 alkyl, CHO, CN, C 1 -C 3 alkoxy, C 1 -C 3 alkoxy optionally substituted with ONO 2; CR 8 =N-OR 9; wherein R 8 is H or CH 3, and wherein R 9 is H or C 1 -C 3 alkyl optionally substituted with OH; R 3 is C 1 -C 4 alkyl optionally substituted with OH, ONO, ONO 2 or C 3 -C 5 cycloalkyl; R 4 is C 1 -C 6 alkyl optionally substituted with C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, F, ONO, ONO 2; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl; X is CR 21 or N; R 20 is C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 21 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 22 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 23 and R 24 are each independently C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 25 is H, or C 1 -C 4 alkyl optionally substituted with F, OH, ONO, ONO 2; R 26 and R 27 are each independently H or C 1 -C 4 alkyl optionally substituted with ONO, ONO 2; R 28 is C 1 -C 4 alkyl optionally substituted with F, ONO, ONO 2. or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula I is a compound of formula I* or a compound of formula II* and wherein at least one of R 2, R 3, R 4, R 20, R 22, R 23 or R 24 independently of each other comprises at least one ONO 2 or ONO moiety; R 1 is C 1 -C 3 alkyl; R 2 is H, C 1 -C 3 alkyl, CHO, CN, C 1 -C 3 alkoxy, C 1 -C 3 alkoxy optionally substituted with ONO 2; CR 8 =N-OR 9; wherein R 8 is H or CH 3, and wherein R 9 is H or C 1 -C 3 alkyl optionally substituted with OH; R 3 is C 1 -C 4 alkyl optionally substituted with OH, ONO, ONO 2 or C 3 -C 5 cycloalkyl; R 4 is C 1 -C 6 alkyl optionally substituted with C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, F, ONO, ONO 2; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl; X is CR 21 or N; R 20 is C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 21 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 22 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 23 and R 24 are each independently C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 25 is H, or C 1 -C 4 alkyl optionally substituted with F, OH, ONO, ONO 2; R 26 and R 27 are each independently H or C 1 -C 4 alkyl optionally substituted with ONO, ONO 2; R 28 is C 1 -C 4 alkyl optionally substituted with F, ONO, ONO 2. at least one of R 2, R 3, R 4, R 20, R 22, R 23 or R 24 independently of each other comprises at least one ONO 2 or ONO moiety; R 1 is C 1 -C 3 alkyl; R 2 is H, C 1 -C 3 alkyl, CHO, CN, C 1 -C 3 alkoxy, C 1 -C 3 alkoxy optionally substituted with ONO 2; CR 8 =N-OR 9; wherein R 8 is H or CH 3, and wherein R 9 is H or C 1 -C 3 alkyl optionally substituted with OH; R 3 is C 1 -C 4 alkyl optionally substituted with OH, ONO, ONO 2 or C 3 -C 5 cycloalkyl; R 4 is C 1 -C 6 alkyl optionally substituted with C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, F, ONO, ONO 2; C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl; X is CR 21 or N; R 20 is C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 21 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 22 is H or C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 23 and R 24 are each independently C 1 -C 4 alkyl optionally substituted with halogen, OH, ONO, ONO 2, C 1 -C 3 alkoxy, C 1 -C 3 haloalkoxy, COOR 25, NR 26 R 27, C=NR 28; R 25 is H, or C 1 -C 4 alkyl optionally substituted with F, OH, ONO, ONO 2; R 26 and R 27 are each independently H or C 1 -C 4 alkyl optionally substituted with ONO, ONO 2; R 28 is C 1 -C 4 alkyl optionally substituted with F, ONO, ONO 2.