Compounds of the formula I in which R denotes Ar or Het, Y denotes -CO-W or -N(R 4)CO-W 1, W denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, Ar or CH 2 Ar, -CONR 2 R 2' or Het 1, W 1 denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, Ar, CH 2 Ar, CH 2 Cyc or CH CH 2 OH, R 1 denotes H, F, Cl, Br, OH, CN, NO 2, A', OA', SA', SO 2 Me, COA', CONH 2, CONHA' or CONA' 2, R 2, R 2' each, independently of one another, denote H, A or [C(R 3) 2] n Cyc, X 1, X 2, X 3 each, independently of one another, denote CR 8 or N, X 4 denotes CR 8 or N, X 5 denotes CR 8 or N, R 4 denotes H or A', A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein two adjacent carbon atoms may form a double bond and/or one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by R 5, Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by OH, Hal or A, A' denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F, R 5 denotes F, Cl or OH, Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, O[C(R 3) 2] n Het 1, Ar 1, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, CON(R 3) 2, Het 1, OCH 2 Cyc, [C(R 3) 2] p N(R 3) 2, N(R 3) 2 COA, NR 3 SO 2 A, [C(R 3) 2] p SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2 and/or COA, Ar 1 denotes phenyl or naphthyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, [C(R 3) 2] p N(R 3) 2, N(R 3) 2 COA, NR 3 SO 2 A, [C(R 3) 2] p SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2 and/or COA, R 3 denotes H or unbranched or branched alkyl with 1-6 C-atoms, R 8 denotes H or A', Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] n OA', [C(R 3) 2] n N(R 3) 2, SR 3, NO 2, CN, COOR 3, CON(R 3) 2, COHet 1, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2, CHO, COA, =S, =NH, =NA and/or =O (carbonyl oxygen), Het 1 denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] n OR 3, [C(R 3) 2] n N(R 3) 2, SR 3, NO 2, CN, COOR 3, CON(R 3) 2, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2, CHO, COA, =S, =NH, =NA and/or =O (carbonyl oxygen), Hal denotes F, Cl, Br or I, m denotes 1, 2 or 3, n denotes 0, 1 or 2, p denotes 0, 1, 2, 3 or 4, q denotes 0, 1, 2 or 3, and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. R denotes Ar or Het, Y denotes -CO-W or -N(R 4)CO-W 1, W denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, Ar or CH 2 Ar, -CONR 2 R 2' or Het 1, W 1 denotes NR 2 R 2', Het 1, CH 2 Het 1, A, Cyc, Ar, CH 2 Ar, CH 2 Cyc or CH CH 2 OH, R 1 denotes H, F, Cl, Br, OH, CN, NO 2, A', OA', SA', SO 2 Me, COA', CONH 2, CONHA' or CONA' 2, R 2, R 2' each, independently of one another, denote H, A or [C(R 3) 2] n Cyc, X 1, X 2, X 3 each, independently of one another, denote CR 8 or N, X 4 denotes CR 8 or N, X 5 denotes CR 8 or N, R 4 denotes H or A', A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein two adjacent carbon atoms may form a double bond and/or one or two non-adjacent CH- and/or CH 2 -groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by R 5, Cyc denotes cycloalkyl with 3-7 C-atoms, which is unsubstituted or monosubstituted by OH, Hal or A, A' denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F, R 5 denotes F, Cl or OH, Ar denotes phenyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, O[C(R 3) 2] n Het 1, Ar 1, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, CON(R 3) 2, Het 1, OCH 2 Cyc, [C(R 3) 2] p N(R 3) 2, N(R 3) 2 COA, NR 3 SO 2 A, [C(R 3) 2] p SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2 and/or COA, Ar 1 denotes phenyl or naphthyl, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] p OR 3, [C(R 3) 2] p N(R 3) 2, NO 2, CN, [C(R 3) 2] p COOR 3, [C(R 3) 2] p N(R 3) 2, N(R 3) 2 COA, NR 3 SO 2 A, [C(R 3) 2] p SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2 and/or COA, R 3 denotes H or unbranched or branched alkyl with 1-6 C-atoms, R 8 denotes H or A', Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] n OA', [C(R 3) 2] n N(R 3) 2, SR 3, NO 2, CN, COOR 3, CON(R 3) 2, COHet 1, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2, CHO, COA, =S, =NH, =NA and/or =O (carbonyl oxygen), Het 1 denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di-, tri-, tetra- or pentasubstituted by Hal, A, [C(R 3) 2] n OR 3, [C(R 3) 2] n N(R 3) 2, SR 3, NO 2, CN, COOR 3, CON(R 3) 2, NR 3 COA, NR 3 SO 2 A, SO 2 N(R 3) 2, S n A, O[C(R 3) 2] m N(R 3) 2, NHCOOA, NHCON(R 3) 2, CHO, COA, =S, =NH, =NA and/or =O (carbonyl oxygen), Hal denotes F, Cl, Br or I, m denotes 1, 2 or 3, n denotes 0, 1 or 2, p denotes 0, 1, 2, 3 or 4, q denotes 0, 1, 2 or 3,