A peptide that binds to and inhibits the activity of Tissue Factor Pathway Inhibitor-1α (TFPI-1α), comprising the following structure of formula: wherein X1001 is an amino acid selected from the group consisting of Bhf, C, F, H, I, K, L, M, N, Nmf, Q, R, T, V, W and Y; wherein X1002 is Q; wherein X1003 is an amino acid selected from the group consisting of A, Aib, Bhs, C, D, E, G, H, I, L, M, N, Q, R, S, T, V, W and Y; wherein X1004 is an amino acid selected from the group consisting of A, Aib, Bhk, C, E, F, G, H, I, K, k, M, N, Nmk, P, Q, R, S, T, V, W and Y; wherein X1005 is an amino acid selected from the group consisting of a, A, Aib, Bal, C, D, d, E, F, G, H, K, k, M, N, Nmg, p, Q, R, S, T, V, W and Y; wherein X1006 is an amino acid selected from the group consisting of A, Aib, Btq, C, D, E, G, H, I, K, M, N, Q, R, S T, V, W and Y; wherein X1007 is an amino acid selected from the group consisting of A, F, I, L, Nmv, P, Q, S, V, Wand Y; wherein X1008 is an amino acid selected from the group consisting of F, H, W and Y; wherein X1009 is an amino acid selected from the group consisting of A, Aib, f, I, S and V; wherein X1010 is an amino acid selected from the group consisting of A, Aib, C, D, E, F, G, H, I, K, L, M, N, Nmf, P, Q, R, S, T, V, W and Y; wherein X1011 is an amino acid selected from the group consisting of Aib, C, K, G and Nmg; wherein X1012 is Y; wherein X1013 is an amino acid selected from the group consisting of A, Aib, C, E, F, H, L, M, Q, R, W and Y; wherein X1014 is an amino acid selected from the group consisting of A, Aib, Bhe, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y; wherein X1015 is R; wherein X1016 is L; wherein X1017 is an amino acid selected from the group consisting of A, Aib, Bhr, C, Cha, Cit, Dab, Dap, E, Eag, Eew, G, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, Q, R, S, T, V, Wand Y; wherein X1018 is an amino acid selected from the group consisting of A, Bal, C, D, E, G, H, I, K, L, M, N, Q, R, S, T, V, W and Y; wherein X1019 is an amino acid selected from the group consisting of Bhk, K and R; and wherein X1020 is either present or absent, whereby in case X1020 is present it is an amino acid selected from the group consisting of Aib, Bhl, C, F, H, I, K, L, Nml, Q, R, S, T, V, W and Y; and wherein the peptide comprises an amino acid sequence of at least 70% identity to: Ac-FQSKpNVHVDGYFERL-Aib-AKL-NH 2 (SEQ ID NO: 178). wherein X1001 is an amino acid selected from the group consisting of Bhf, C, F, H, I, K, L, M, N, Nmf, Q, R, T, V, W and Y; wherein X1002 is Q; wherein X1003 is an amino acid selected from the group consisting of A, Aib, Bhs, C, D, E, G, H, I, L, M, N, Q, R, S, T, V, W and Y; wherein X1004 is an amino acid selected from the group consisting of A, Aib, Bhk, C, E, F, G, H, I, K, k, M, N, Nmk, P, Q, R, S, T, V, W and Y; wherein X1005 is an amino acid selected from the group consisting of a, A, Aib, Bal, C, D, d, E, F, G, H, K, k, M, N, Nmg, p, Q, R, S, T, V, W and Y; wherein X1006 is an amino acid selected from the group consisting of A, Aib, Btq, C, D, E, G, H, I, K, M, N, Q, R, S T, V, W and Y; wherein X1007 is an amino acid selected from the group consisting of A, F, I, L, Nmv, P, Q, S, V, Wand Y; wherein X1008 is an amino acid selected from the group consisting of F, H, W and Y; wherein X1009 is an amino acid selected from the group consisting of A, Aib, f, I, S and V; wherein X1010 is an amino acid selected from the group consisting of A, Aib, C, D, E, F, G, H, I, K, L, M, N, Nmf, P, Q, R, S, T, V, W and Y; wherein X1011 is an amino acid selected from the group consisting of Aib, C, K, G and Nmg; wherein X1012 is Y; wherein X1013 is an amino acid selected from the group consisting of A, Aib, C, E, F, H, L, M, Q, R, W and Y; wherein X1014 is an amino acid selected from the group consisting of A, Aib, Bhe, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W and Y; wherein X1015 is R; wherein X1016 is L; wherein X1017 is an amino acid selected from the group consisting of A, Aib, Bhr, C, Cha, Cit, Dab, Dap, E, Eag, Eew, G, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, Q, R, S, T, V, Wand Y; wherein X1018 is an amino acid selected from the group consisting of A, Bal, C, D, E, G, H, I, K, L, M, N, Q, R, S, T, V, W and Y; wherein X1019 is an amino acid selected from the group consisting of Bhk, K and R; and wherein X1020 is either present or absent, whereby in case X1020 is present it is an amino acid selected from the group consisting of Aib, Bhl, C, F, H, I, K, L, Nml, Q, R, S, T, V, W and Y; and wherein the peptide comprises an amino acid sequence of at least 70% identity to: Ac-FQSKpNVHVDGYFERL-Aib-AKL-NH 2 (SEQ ID NO: 178).