mhurhangee/ep-ind-claims huggingface dataset:
A screening method for biologically active agents that inhibit QPCTL activity in vivo, comprising: i) determining the effect of the test agent that has already been administered to a disease-specific mouse or rat model; ii) comparing the effect of the test agent with the effect of a QPCTL gene knock-out in said disease-specific non-human animal model, and iii) selecting test agents that have an efficacy similar to the effect of the QPCTL gene knock-out on the specific disease; wherein • the mouse or rat of step ii) is heterozygous or homozygous for the knock-out mutation in the QPCTL gene; • the mouse or rat of step ii) is selected from the group consisting of a) PDAPP, Tg2576, APP23, TgCRND8, PSEN 1M146V or PSEN 1M146L, PSAPP, APP Dutch, BKI-Aβ40 and BRI-Aβ42, JNPL3, Tau P301S, Tau V337M, Tau R406W, rTg4510, H tau, TAPP and 3 x TgAD and non-human transgenic animal models, wherein the transgene encodes at least one amyloid beta (Aβ) peptide selected from the group consisting of AβN3E-42, AβN3Q-42, AβN3E-40 and AβN3Q-40; and b) the apolipoprotein E knock-out mouse model, the thioglycollate-induced inflammation model in mice, the collagen-induced arthritis model in rat, the antibody induced arthritis model in rat and rat models of restenosis; and • the effect of the test agents is an inhibition of the formation of at least one peptide selected from pGlu-MCP-1, pGlu-MCP-2, pGlu-MCP-3, pGlu-MCP-4, [pGlu 3]Aβ3-40/42 or [pGlu 11]Aβ11-40/42. i) determining the effect of the test agent that has already been administered to a disease-specific mouse or rat model; ii) comparing the effect of the test agent with the effect of a QPCTL gene knock-out in said disease-specific non-human animal model, and iii) selecting test agents that have an efficacy similar to the effect of the QPCTL gene knock-out on the specific disease; • the mouse or rat of step ii) is heterozygous or homozygous for the knock-out mutation in the QPCTL gene; • the mouse or rat of step ii) is selected from the group consisting of a) PDAPP, Tg2576, APP23, TgCRND8, PSEN 1M146V or PSEN 1M146L, PSAPP, APP Dutch, BKI-Aβ40 and BRI-Aβ42, JNPL3, Tau P301S, Tau V337M, Tau R406W, rTg4510, H tau, TAPP and 3 x TgAD and non-human transgenic animal models, wherein the transgene encodes at least one amyloid beta (Aβ) peptide selected from the group consisting of AβN3E-42, AβN3Q-42, AβN3E-40 and AβN3Q-40; and b) the apolipoprotein E knock-out mouse model, the thioglycollate-induced inflammation model in mice, the collagen-induced arthritis model in rat, the antibody induced arthritis model in rat and rat models of restenosis; and • the effect of the test agents is an inhibition of the formation of at least one peptide selected from pGlu-MCP-1, pGlu-MCP-2, pGlu-MCP-3, pGlu-MCP-4, [pGlu 3]Aβ3-40/42 or [pGlu 11]Aβ11-40/42.
A method implemented in a network node (10, 960) in a wireless communication system, comprising: • configuring a wireless device (12, 910) to measure Reference Signal Received Power, RSRP, for both a serving cell of the wireless device (12, 910) and one or more neighbor cells of the wireless device (12, 910); • receiving, from the wireless device (12, 910), reporting information comprising: o a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a RSRP difference between a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a plurality of serving cell RSRP measurements for the serving cell of the wireless device (12, 910) and a plurality of neighbor cell RSRP measurements for one or more neighbor cells of the wireless device (12, 910); • adjusting a target receive power for the wireless device (12, 910) based on the reporting information; • determining a power correction for the wireless device (12, 910) based on the adjusted target receive power for the wireless device (12, 910); and • signaling the power correction to the wireless device (12, 910). • configuring a wireless device (12, 910) to measure Reference Signal Received Power, RSRP, for both a serving cell of the wireless device (12, 910) and one or more neighbor cells of the wireless device (12, 910); • receiving, from the wireless device (12, 910), reporting information comprising: o a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a RSRP difference between a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a plurality of serving cell RSRP measurements for the serving cell of the wireless device (12, 910) and a plurality of neighbor cell RSRP measurements for one or more neighbor cells of the wireless device (12, 910); o a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a RSRP difference between a serving cell RSRP measurement for the serving cell of the wireless device (12, 910) and a neighbor cell RSRP measurement for a neighbor cell of the wireless device (12, 910); or o a plurality of serving cell RSRP measurements for the serving cell of the wireless device (12, 910) and a plurality of neighbor cell RSRP measurements for one or more neighbor cells of the wireless device (12, 910); • adjusting a target receive power for the wireless device (12, 910) based on the reporting information; • determining a power correction for the wireless device (12, 910) based on the adjusted target receive power for the wireless device (12, 910); and • signaling the power correction to the wireless device (12, 910).
A driving control system for a vehicle, comprising - a sensor unit, - a data storage unit, and - a control unit, the sensor unit being arrangeable in the vehicle and configured to detect at least one driving parameter of the vehicle during travelling, the control unit being configured to generate at least one driving mode based on the at least one driving parameter, the data storage unit being configured to store the at least one driving mode, the control unit being configured to receive an input whether the vehicle continues traveling in a current driving mode or changes to one of the driving modes stored in the data storage unit, and the control unit being further configured to simulate the driving mode based on the input, even though the vehicle stops travelling, characterized in that the control unit is further configured to simulate the determined driving mode, even though the vehicle ends travelling. - a sensor unit, - a data storage unit, and - a control unit, the sensor unit being arrangeable in the vehicle and configured to detect at least one driving parameter of the vehicle during travelling, the control unit being configured to generate at least one driving mode based on the at least one driving parameter, the data storage unit being configured to store the at least one driving mode, the control unit being configured to receive an input whether the vehicle continues traveling in a current driving mode or changes to one of the driving modes stored in the data storage unit, and the control unit being further configured to simulate the driving mode based on the input, even though the vehicle stops travelling, characterized in that the control unit is further configured to simulate the determined driving mode, even though the vehicle ends travelling.
A method of making a solid triamine composition comprising: mixing a triamine and an acid, wherein the acid is selected from the group consisting of citric acid, tartaric acid, malic acid, maleic acid, malonic acid, succinic acid, adipic acid, aspartic acid, glutamic acid, dipicolinic acid, acetic acid, and benzoic acid, and wherein the triamine has the following formula: wherein R is a straight chain C1-C12 alkyl group; and at least partially neutralizing the triamine to form a solid amine salt; wherein the reaction occurs at a temperature between 21°C (70°F) and 55°C (130°F). mixing a triamine and an acid, wherein the acid is selected from the group consisting of citric acid, tartaric acid, malic acid, maleic acid, malonic acid, succinic acid, adipic acid, aspartic acid, glutamic acid, dipicolinic acid, acetic acid, and benzoic acid, and wherein the triamine has the following formula: wherein R is a straight chain C1-C12 alkyl group; and at least partially neutralizing the triamine to form a solid amine salt; wherein the reaction occurs at a temperature between 21°C (70°F) and 55°C (130°F).
An isolated antibody that specifically binds human ROR1 protein on cancer cells and is comprised of a heavy chain variable region coded by a polynucleotide having the sequence of SEQ ID NO: 13, and a corresponding light chain variable region coded by a polynucleotide having the sequence of SEQ ID NO: 15, wherein the antibody binds the Ig-like region of the extracellular domain of human ROR-1 protein from position 1-147, or residues 130-160 within the Ig-like region and adjacent linker region between the Ig-like domain and the CDR domain of the extracellular domain of human ROR-1 protein from position 1-165.
A power generation control apparatus comprising: first DC input terminals (101-1, 102-1) for inputting first DC power; a first noise filter connected to the first DC input terminals (101-1, 102-1); second DC input terminals (101-2, 102-2) for inputting second DC power; and a second noise filter connected to the second DC input terminals (101-2, 102-2); characterized in that the first noise filter is connected to a ground and includes a first common mode noise filter comprising two capacitors (114-1, 115-1) having a first capacitance value, and the second noise filter is connected to the ground and includes a second common mode noise filter comprising two capacitors (114-2, 115-2) having a second capacitance value different from the first capacitance value such that a frequency band of noise is dispersed. first DC input terminals (101-1, 102-1) for inputting first DC power; a first noise filter connected to the first DC input terminals (101-1, 102-1); second DC input terminals (101-2, 102-2) for inputting second DC power; and a second noise filter connected to the second DC input terminals (101-2, 102-2); characterized in that the first noise filter is connected to a ground and includes a first common mode noise filter comprising two capacitors (114-1, 115-1) having a first capacitance value, and the second noise filter is connected to the ground and includes a second common mode noise filter comprising two capacitors (114-2, 115-2) having a second capacitance value different from the first capacitance value such that a frequency band of noise is dispersed.
A railway vehicle comprising at least one car and at least one bogie carrying the car, the bogie comprising a chassis and a secondary suspension system between the chassis and the car, the secondary suspension system, comprising: - a set of springs mounted between the chassis and the car; - a jack comprising two ends (44, 46) extending along a same axis; and - a supply system of the jack; the jack being configured to go from a first so-called retracted configuration in which the jack is only connected to the car by the first end of the jack, to a second so-called deployed configuration in which the jack is also connected to the chassis by the second end of the jack, the power supply device being configured, in the deployed configuration, to supply the jack so as to move the car away from the chassis or to keep the distance between the car and the chassis constant, characterized in that the first end of the jack is connected to the car by a knuckle joint-type connection. - a set of springs mounted between the chassis and the car; - a jack comprising two ends (44, 46) extending along a same axis; and - a supply system of the jack;
An actinic ray-sensitive or radiation-sensitive resin composition characterized by comprising: a resin that exhibits an increased solubility in an alkali developer when acted on by an acid, at least two types of sulfonic acid generators that generate a sulfonic acid when exposed to actinic rays or radiation, wherein the two types of sulfonic acid generators consist of sulfonic acid generators and satisfying the following requirements: the sulfonic acid generator generates a sulfonic acid containing 9-20 atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship pKa < -3.50, and the sulfonic acid generator generates a sulfonic acid containing 17 or more atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship -2.00 > pKa ≥ -3.50; and two or more types of acid diffusion inhibitors capable of controlling the diffusion of the acids generated from the sulfonic acid generators. a resin that exhibits an increased solubility in an alkali developer when acted on by an acid, at least two types of sulfonic acid generators that generate a sulfonic acid when exposed to actinic rays or radiation, wherein the two types of sulfonic acid generators consist of sulfonic acid generators and satisfying the following requirements: the sulfonic acid generator generates a sulfonic acid containing 9-20 atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship pKa < -3.50, and the sulfonic acid generator generates a sulfonic acid containing 17 or more atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship -2.00 > pKa ≥ -3.50; and the sulfonic acid generator generates a sulfonic acid containing 9-20 atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship pKa < -3.50, and the sulfonic acid generator generates a sulfonic acid containing 17 or more atoms other than hydrogen and having an acid strength (pKa) satisfying the relationship -2.00 > pKa ≥ -3.50; and two or more types of acid diffusion inhibitors capable of controlling the diffusion of the acids generated from the sulfonic acid generators.
Method for searching for at least a specific datum among data stored in a permanent memory of a user unit linked to a central authority, comprising: - receiving from said central authority, said at least one specific datum converted by a second one-way function using a processing key; - converting at least a part of the data stored in the permanent memory of the user unit, by said second one-way function and said processing key; - in the user unit, comparing said at least one converted specific datum received from the central authority with the converted data from the permanent memory of the user unit, thereby providing a search result; characterized in that the step for converting at least a part of the data stored in the permanent memory of the user unit is performed in said user unit and the method further comprises: - receiving, in said user unit, the processing key derived, in said central authority, by means of a key derivation function applied on at least a secret piece of information, said key derivation function being a first iterative one-way function which consumes time for generating the processing key. - receiving from said central authority, said at least one specific datum converted by a second one-way function using a processing key; - converting at least a part of the data stored in the permanent memory of the user unit, by said second one-way function and said processing key; - in the user unit, comparing said at least one converted specific datum received from the central authority with the converted data from the permanent memory of the user unit, thereby providing a search result; - receiving, in said user unit, the processing key derived, in said central authority, by means of a key derivation function applied on at least a secret piece of information, said key derivation function being a first iterative one-way function which consumes time for generating the processing key.
A method performed by a remote radio unit, RRU, of a distributed base station system of a wireless communication network, the distributed base station system further comprising a base band unit, BBU, connected to the RRU, the RRU being connected to a plurality of antennas (121, 122, 123) through which the RRU transmits user-layer signals to a plurality of UEs (161, 162, 163), the user-layer signals being transmitted using same time-frequency resource, the method comprising: receiving uplink signals from the plurality of UEs; sending information related to the received uplink signals to the BBU so that the BBU can obtain a first part of precoding coefficients to be used for precoding digital user-layer signals in frequency domain; obtaining a second part of the precoding coefficients; receiving, from the BBU, the digital user-layer signals precoded using the first part of the precoding coefficients, precoding the received digital user-layer signals in frequency domain with the second part of the precoding coefficients, converting the digital user-layer signals precoded with the first and the second part of the precoding coefficients to analog user-layer signals, and transmitting the analog user-layer signals to the plurality of UEs (161, 162, 163) via the plurality of antennas (121, 122, 123). receiving uplink signals from the plurality of UEs; sending information related to the received uplink signals to the BBU so that the BBU can obtain a first part of precoding coefficients to be used for precoding digital user-layer signals in frequency domain; obtaining a second part of the precoding coefficients; receiving, from the BBU, the digital user-layer signals precoded using the first part of the precoding coefficients, precoding the received digital user-layer signals in frequency domain with the second part of the precoding coefficients, converting the digital user-layer signals precoded with the first and the second part of the precoding coefficients to analog user-layer signals, and transmitting the analog user-layer signals to the plurality of UEs (161, 162, 163) via the plurality of antennas (121, 122, 123).
A method for adjusting a write timing in a memory device, comprising: receiving, by the memory device, a data signal (130 0), a write clock signal, and a reference signal; detecting, by the memory device, a phase shift in the reference signal; generating, by the memory device, a phase error signal based on the phase shift; and adjusting, by the memory device, a phase difference between the data signal (130 0) and the write clock signal based on the phase error signal, wherein the memory device recovers data from the data signal (130 0) based on an adjusted write timing of the data signal (130 0) and the write clock signal. receiving, by the memory device, a data signal (130 0), a write clock signal, and a reference signal; detecting, by the memory device, a phase shift in the reference signal; generating, by the memory device, a phase error signal based on the phase shift; and adjusting, by the memory device, a phase difference between the data signal (130 0) and the write clock signal based on the phase error signal, wherein the memory device recovers data from the data signal (130 0) based on an adjusted write timing of the data signal (130 0) and the write clock signal.
A system comprising one or more processors and memory, which memory comprises instructions executable by the one or more processors and which memory comprises counts of nucleotide sequence reads mapped to genomic sections of a reference genome, which sequence reads are reads of circulating cell-free nucleic acid from a test sample from a pregnant female, and which instructions executable by the one or more processors are configured to: (a) remove from the counts nucleotide sequence reads that are from nucleic acid fragments equal to or longer than 160 bases, thereby generating counts of reads from nucleic acid fragments that are shorter than 160 bases; (b) normalize the counts, thereby generating normalized counts of sequence reads mapped to the genomic sections; and (c) determine the presence or absence of a chromosome aneuploidy according to the normalized counts. (a) remove from the counts nucleotide sequence reads that are from nucleic acid fragments equal to or longer than 160 bases, thereby generating counts of reads from nucleic acid fragments that are shorter than 160 bases; (b) normalize the counts, thereby generating normalized counts of sequence reads mapped to the genomic sections; and (c) determine the presence or absence of a chromosome aneuploidy according to the normalized counts.
A method for manufacturing a mold for molding a tire, comprising the steps of: pouring a molten metal into a casting space of a casting mold in which a wire is disposed; casting a cast metal of the mold for molding a tire with the wire cast-in in the casting space; and forming a vent hole by withdrawing the wire from the cast metal; the method further comprising the steps of: calculating a contact angle (θ) of the wire at which a bent amount of the wire is within an allowable range from conditions of an actual length and a diameter of the wire by using a relational expression indicating a relation among a length of the wire in the casting space, a diameter of the wire, the contact angle (θ) of the wire with respect to the molten metal, and the bent amount of the wire by casting, which is acquired by experiments in advance; and disposing the wire in the casting space on the basis of the calculated contact angle (θ) of the wire. pouring a molten metal into a casting space of a casting mold in which a wire is disposed; casting a cast metal of the mold for molding a tire with the wire cast-in in the casting space; and forming a vent hole by withdrawing the wire from the cast metal; the method further comprising the steps of: calculating a contact angle (θ) of the wire at which a bent amount of the wire is within an allowable range from conditions of an actual length and a diameter of the wire by using a relational expression indicating a relation among a length of the wire in the casting space, a diameter of the wire, the contact angle (θ) of the wire with respect to the molten metal, and the bent amount of the wire by casting, which is acquired by experiments in advance; and disposing the wire in the casting space on the basis of the calculated contact angle (θ) of the wire. calculating a contact angle (θ) of the wire at which a bent amount of the wire is within an allowable range from conditions of an actual length and a diameter of the wire by using a relational expression indicating a relation among a length of the wire in the casting space, a diameter of the wire, the contact angle (θ) of the wire with respect to the molten metal, and the bent amount of the wire by casting, which is acquired by experiments in advance; and disposing the wire in the casting space on the basis of the calculated contact angle (θ) of the wire.