A compound comprising a compound from formula or formula: wherein R 1 is selected from the group consisting of hydrogen, 2- or 3- or 4-halo-phenyl, heteroalkyl, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein R 2 is selected from the group consisting of 2- or 3- or 4-halo-phenyl, heteroalkyl, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein R 3 and R 4 are independently selected from the group consisting of heteroalkyl, aminoalkyl, aryl, arylalkyl, carboxyalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, or R 3 or R 4 are independently an ionizing group selected from the group consisting of carboxylates, amines, phosphonates, and phosphates; wherein R 3 is also selected from the group consisting of -B(R 5 R 6), -BF 3 - M +, -R 7 -B(R 5 R 6), -R 7 -BF 3 - M +, -C -R 7, -O-R 7, -S y -R 7 (wherein y = 0, 1, or 2), -P -(R 5 R 6) and-N(R 8 R 9); wherein R 4 is also selected from the group consisting of -B(R 5 R 6), -BF 3 - M +, -R 7 -B(R 5 R 6), -R 7 -BF 3 - M +, -C - R 7, -O-R 7, -S y -R 7 (wherein y = 0, 1, or 2), -P -(R 5 R 6) and-N(R 8 R 9); wherein R 7 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl; wherein M + is a Group I or a Group II metal; wherein R 5 and R 6 are independently hydrogen, hydroxyl, aryloxy, or alkoxy, or wherein R 5 and R 6 together form a cyclic ester, or an acid anhydride (either mixed or symmetrical); wherein R 8 and R 9 are independently selected from hydrogen, alkyl, haloalkyl, aryl, cycloalkyl, arylalkyl, heteroalkyl, heterocyclyl and heterocyclylalkyl; R 8 and R 9 are both oxygen to form a nitro group; or R 8 and R 9 together with the nitrogen to which they are attached, form a heterocyclyl; wherein n is 1; and wherein X 1 is nitrogen; and pharmaceutical compositions thereof; wherein the term alkyl refers to a saturated or unsaturated, straight or branched, hydrocarbon chain. wherein R 1 is selected from the group consisting of hydrogen, 2- or 3- or 4-halo-phenyl, heteroalkyl, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein R 2 is selected from the group consisting of 2- or 3- or 4-halo-phenyl, heteroalkyl, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein R 3 and R 4 are independently selected from the group consisting of heteroalkyl, aminoalkyl, aryl, arylalkyl, carboxyalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, or R 3 or R 4 are independently an ionizing group selected from the group consisting of carboxylates, amines, phosphonates, and phosphates; wherein R 3 is also selected from the group consisting of -B(R 5 R 6), -BF 3 - M +, -R 7 -B(R 5 R 6), -R 7 -BF 3 - M +, -C -R 7, -O-R 7, -S y -R 7 (wherein y = 0, 1, or 2), -P -(R 5 R 6) and-N(R 8 R 9); wherein R 4 is also selected from the group consisting of -B(R 5 R 6), -BF 3 - M +, -R 7 -B(R 5 R 6), -R 7 -BF 3 - M +, -C - R 7, -O-R 7, -S y -R 7 (wherein y = 0, 1, or 2), -P -(R 5 R 6) and-N(R 8 R 9); wherein R 7 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl; wherein M + is a Group I or a Group II metal; wherein R 5 and R 6 are independently hydrogen, hydroxyl, aryloxy, or alkoxy, or wherein R 5 and R 6 together form a cyclic ester, or an acid anhydride (either mixed or symmetrical); wherein R 8 and R 9 are independently selected from hydrogen, alkyl, haloalkyl, aryl, cycloalkyl, arylalkyl, heteroalkyl, heterocyclyl and heterocyclylalkyl; R 8 and R 9 are both oxygen to form a nitro group; or R 8 and R 9 together with the nitrogen to which they are attached, form a heterocyclyl; wherein n is 1; and wherein X 1 is nitrogen; and pharmaceutical compositions thereof; wherein the term alkyl refers to a saturated or unsaturated, straight or branched, hydrocarbon chain.