mhurhangee/ep-ind-claims huggingface dataset:
A method for producing a host cell protein-reduced (HCP-reduced) anti-IL-13 antibody preparation from a sample mixture comprising an anti-IL-13 antibody and at least one HCP, said method comprising: (a) filtrating said sample mixture with a depth filtration filter and collecting a depth filtrated sample mixture; (b) contacting said depth filtrated sample mixture with a Protein A affinity chromatography resin, washing said affinity chromatography resin with a buffer comprising 25 mM Tris, 100 mM NaCl, pH 7.2, followed by a wash with a buffer comprising 20 mM sodium citrate/citric acid, 0.5 M NaCl, pH 6, and then with a buffer comprising 25 mM Tris, 100 mM NaCl, pH 7.2 and collecting an affinity chromatography sample; (c) subjecting said affinity chromatography sample to a reduction in pH thus forming a reduced pH sample, wherein said reduced pH sample has a pH of about 3 to about 4; (d) adjusting the pH of said reduced pH sample to a pH of about 4.5 to about 8.5 and contacting said adjusted pH sample with an anion exchange resin comprising a quaternary aminoethyl anionic substituent and collecting an ion exchange sample; and (e) contacting said ion exchange sample with a hydrophobic interaction chromatography material and collecting an HIC sample, wherein said HIC sample comprises said HCP-reduced antibody preparation, wherein about refers to 20% greater than or less than the referenced value, and wherein said anti-IL-13 antibody is a humanized IgA 1, IgA 2, IgG 1, IgG 2, IgG 4, or IgM antibody comprising a heavy chain variable region of EVTLRESGPGLVKPTQTLTLTCTLYGFSLSTSDMGVDWIRQPPGKGLEWLAHIWWDDVKRYN PALKSRLTISKDTSKNQVVLKLTSVDPVDTATYYCARTVSSGYIYYAMDYWGQGTLVTVSS and a light chain variable region of (a) filtrating said sample mixture with a depth filtration filter and collecting a depth filtrated sample mixture; (b) contacting said depth filtrated sample mixture with a Protein A affinity chromatography resin, washing said affinity chromatography resin with a buffer comprising 25 mM Tris, 100 mM NaCl, pH 7.2, followed by a wash with a buffer comprising 20 mM sodium citrate/citric acid, 0.5 M NaCl, pH 6, and then with a buffer comprising 25 mM Tris, 100 mM NaCl, pH 7.2 and collecting an affinity chromatography sample; (c) subjecting said affinity chromatography sample to a reduction in pH thus forming a reduced pH sample, wherein said reduced pH sample has a pH of about 3 to about 4; (d) adjusting the pH of said reduced pH sample to a pH of about 4.5 to about 8.5 and contacting said adjusted pH sample with an anion exchange resin comprising a quaternary aminoethyl anionic substituent and collecting an ion exchange sample; and (e) contacting said ion exchange sample with a hydrophobic interaction chromatography material and collecting an HIC sample, wherein said HIC sample comprises said HCP-reduced antibody preparation,
A system for detecting the presence of an analyte forming complexes with paramagnetic nanoparticles, comprising: a concentrating magnet system (704, 1205) configured to apply a first, non-uniform magnetic field to the sample, such that said first magnetic field urges said particles in the direction of increasing field strength, thereby causing movement of said complexes, enhancing interactions with each other and concentrating said complexes; a magnetic resonance system (700, 1206), including a second, uniform magnetic field, said magnetic resonance system configured to excite magnetic resonance signals from a liquid, determine said T2 of the liquid by analyzing said magnetic resonance signals and determine whether the analyte is present in said sample by comparing said determined T2 with a predetermined value; and a fluidics system containing a reservoir for storing nanoparticles and water, and a collector for storing the analyte, the fluidics system being configured to: form a sample by mixing nanometer-scale paramagnetic particles and water from said reservoir, and the analyte from said collector, to form a mixed sample; transport the mixed sample to the concentrating magnetic system; and then transport the sample to the sample area of the magnetic resonance system. a concentrating magnet system (704, 1205) configured to apply a first, non-uniform magnetic field to the sample, such that said first magnetic field urges said particles in the direction of increasing field strength, thereby causing movement of said complexes, enhancing interactions with each other and concentrating said complexes; a magnetic resonance system (700, 1206), including a second, uniform magnetic field, said magnetic resonance system configured to excite magnetic resonance signals from a liquid, determine said T2 of the liquid by analyzing said magnetic resonance signals and determine whether the analyte is present in said sample by comparing said determined T2 with a predetermined value; and a fluidics system containing a reservoir for storing nanoparticles and water, and a collector for storing the analyte, the fluidics system being configured to: form a sample by mixing nanometer-scale paramagnetic particles and water from said reservoir, and the analyte from said collector, to form a mixed sample; transport the mixed sample to the concentrating magnetic system; and then transport the sample to the sample area of the magnetic resonance system. form a sample by mixing nanometer-scale paramagnetic particles and water from said reservoir, and the analyte from said collector, to form a mixed sample; transport the mixed sample to the concentrating magnetic system; and then transport the sample to the sample area of the magnetic resonance system.
An injection device, comprising: a body for containing and dispensing a medicament, the body having a plurality of dosage indicator windows (120, 124, 336, 340, 344) for indicating a desired dosage of medicament; and a dose set sleeve (192, 326,352) rotatably connected with the body for setting the desired dosage, the dose set sleeve (192, 326,352) having a plurality of dosage numbers (196, 314,318, 348) disposed thereon; characterized in that the dosage numbers (196, 314,318, 348) and at least one of blank spaces and non-number indicators are arranged on the dose set sleeve (192, 326,352) in parallel helical patterns (356, 360, 364) such that upon rotating the dose set sleeve (192, 326,352) to set the desired dosage, the dosage numbers (196, 314,318, 348) are consecutively visible through alternating ones of the plurality of dosage indicator windows (120, 124, 336, 340, 344) while a dosage number is not visible through one or more other dosage indicator windows (120, 124, 336, 340, 344) of the plurality. a body for containing and dispensing a medicament, the body having a plurality of dosage indicator windows (120, 124, 336, 340, 344) for indicating a desired dosage of medicament; and a dose set sleeve (192, 326,352) rotatably connected with the body for setting the desired dosage, the dose set sleeve (192, 326,352) having a plurality of dosage numbers (196, 314,318, 348) disposed thereon; characterized in that the dosage numbers (196, 314,318, 348) and at least one of blank spaces and non-number indicators are arranged on the dose set sleeve (192, 326,352) in parallel helical patterns (356, 360, 364) such that upon rotating the dose set sleeve (192, 326,352) to set the desired dosage, the dosage numbers (196, 314,318, 348) are consecutively visible through alternating ones of the plurality of dosage indicator windows (120, 124, 336, 340, 344) while a dosage number is not visible through one or more other dosage indicator windows (120, 124, 336, 340, 344) of the plurality.
A method of processing a porous article, the method comprising: (a) distributing a blended powder material including loose electrically conductive particles and loose resin particles into a mold; (b) consolidating the blended powder material within the mold under a molding pressure and a molding temperature into a consolidated article, characterized by (c) selecting the loose resin particles in step (a) to be within a predefined particle size distribution to control a physical property, namely the strength, of the porous article, wherein the predefined particle size distribution includes 95% by volume of the loose resin particles being 22 micrometers or less in average diameter, and wherein the standard deviation of the average diameter is 6 micrometers or less. (a) distributing a blended powder material including loose electrically conductive particles and loose resin particles into a mold; (b) consolidating the blended powder material within the mold under a molding pressure and a molding temperature into a consolidated article, (c) selecting the loose resin particles in step (a) to be within a predefined particle size distribution to control a physical property, namely the strength, of the porous article,
A circuit for mixing an electrical input signal with an optical input signal to obtain an electrical output signal, the circuit comprising: a phototransistor with an input for the electrical input signal; an input for the optical input signal; and an output for the electrical output signal, the circuit further being adapted to operate the phototransistor in an overdrive state such that the output electrical signal comprises a clipped product signal of the electrical input signal and the optical input signal. a phototransistor with an input for the electrical input signal; an input for the optical input signal; and an output for the electrical output signal, the circuit further being adapted to operate the phototransistor in an overdrive state such that the output electrical signal comprises a clipped product signal of the electrical input signal and the optical input signal.
An automatic storage system for use with a processing apparatus having at least a transfer port, comprising: a plurality of shelves facing the processing apparatus, at least one of the shelves being movably provided above the transfer port; a transferring apparatus configured to transfer an article between the shelves and the transfer port; and a mover configured to move the transferring apparatus and the at least one of the shelves above the transfer port, the mover being movable in a first horizontal direction toward and away from a first position where the plurality of shelves are provided above the transfer port, the automatic storage system being characterized in that the mover is fixable at the first position separately from the processing apparatus. a plurality of shelves facing the processing apparatus, at least one of the shelves being movably provided above the transfer port; a transferring apparatus configured to transfer an article between the shelves and the transfer port; and a mover configured to move the transferring apparatus and the at least one of the shelves above the transfer port, the mover being movable in a first horizontal direction toward and away from a first position where the plurality of shelves are provided above the transfer port, the automatic storage system being characterized in that the mover is fixable at the first position separately from the processing apparatus.
An inlet guide vane comprising: a movable vane that has a vane main body and a shaft portion disposed in an end portion of the vane main body; a frame that has an insertion hole into which the shaft portion is to be inserted; a plurality of bearing portions that are arranged inside the insertion hole at an interval in a direction of a central axis (Cs) of the shaft portion, and that support the shaft portion so as to be rotatable around the central axis (Cs) with respect to the frame; and a seal portion that is located inside the insertion hole between the plurality of bearing portions in the direction of the central axis (Cs), and that is configured to seal between the insertion hole and the shaft portion, wherein the shaft portion is disposed integrally with a radially outer end portion of the vane main body, characterized in that the seal portion includes a first seal member and a second seal member which are located at an interval in the direction of the central axis (Cs). a movable vane that has a vane main body and a shaft portion disposed in an end portion of the vane main body; a frame that has an insertion hole into which the shaft portion is to be inserted; a plurality of bearing portions that are arranged inside the insertion hole at an interval in a direction of a central axis (Cs) of the shaft portion, and that support the shaft portion so as to be rotatable around the central axis (Cs) with respect to the frame; and a seal portion that is located inside the insertion hole between the plurality of bearing portions in the direction of the central axis (Cs), and that is configured to seal between the insertion hole and the shaft portion, wherein the shaft portion is disposed integrally with a radially outer end portion of the vane main body, characterized in that the seal portion includes a first seal member and a second seal member which are located at an interval in the direction of the central axis (Cs).
A method of manufacturing an array substrate, comprising: a step of forming a pattern including a data line and a pixel electrode, a step of forming a pattern including a first electrode, for shielding the voltage signal of the data line, and a second common electrode, wherein the first electrode and the second common electrode are adapted to be powered independently, the projection of the first electrode onto the layer where the data line is located covers the data line, and the projection of the second common electrode onto the layer where the pixel electrode is located, falls onto the pixel electrode, and when forming the pattern of the first electrode, the first electrode is connected to a common electrode power supply circuit of a peripheral circuit, the method further comprising the step of forming a pattern of a common electrode line, wherein the second common electrode is connected to the common electrode line, and wherein the first electrode is adapted to serve as a shielding electrode for the data line. a step of forming a pattern including a data line and a pixel electrode, a step of forming a pattern including a first electrode, for shielding the voltage signal of the data line, and a second common electrode, wherein the first electrode and the second common electrode are adapted to be powered independently, the projection of the first electrode onto the layer where the data line is located covers the data line, and the projection of the second common electrode onto the layer where the pixel electrode is located, falls onto the pixel electrode, and when forming the pattern of the first electrode, the first electrode is connected to a common electrode power supply circuit of a peripheral circuit, the method further comprising the step of forming a pattern of a common electrode line, wherein the second common electrode is connected to the common electrode line, and wherein the first electrode is adapted to serve as a shielding electrode for the data line.
A method for identifying viewing information of media associated with a digital media device (12; 304) comprising: monitoring a data bus (26; 312) communicatively coupled to a processor and to a data storage device (24; 310) associated with the digital media device (12; 304); identifying, on the data bus (26; 312), write commands to be processed by the data storage device (24; 310) to write the media to the data storage device (24; 310), and read commands to be processed by the data storage device (24; 310) to read the media from the data storage device (24; 310); generating event records based on the identified write commands, the event records including at least a record time and storage location; adding at least a view time to the generated event records in response to a read command; determining a relationship between the view time and a delay time associated with event records included in the sequence of events records, the delay time of an event record representative of a difference between the view time and the record time associated with the respective event record; and based on the determined relationship, identifying occurrences of at least one of live viewing of broadcast media, recording of media, or playback of previously recorded media stored on the data storage device (24; 310). monitoring a data bus (26; 312) communicatively coupled to a processor and to a data storage device (24; 310) associated with the digital media device (12; 304); identifying, on the data bus (26; 312), write commands to be processed by the data storage device (24; 310) to write the media to the data storage device (24; 310), and read commands to be processed by the data storage device (24; 310) to read the media from the data storage device (24; 310); generating event records based on the identified write commands, the event records including at least a record time and storage location; adding at least a view time to the generated event records in response to a read command; determining a relationship between the view time and a delay time associated with event records included in the sequence of events records, the delay time of an event record representative of a difference between the view time and the record time associated with the respective event record; and based on the determined relationship, identifying occurrences of at least one of live viewing of broadcast media, recording of media, or playback of previously recorded media stored on the data storage device (24; 310).
A method for lining a cathode of a reduction cell for production of aluminum, which includes filling a cathode device shell with a thermal insulation layer and leveling said layer; filling, leveling and compacting a refractory layer; installing bottom and side blocks followed by sealing joints therebetween with a cold ramming paste, characterized in that prior to filling a shell bottom with the thermal insulation layer a layer of fine carbonized particles in the form of woodflour or hard- of softwood sawdust is formed wherein the method is characterized in that in order to obtain a density from 250 to 600 kg/m3, respectively, the fine carbonized particles are compacted to a height of 5-25 % of the height of a space under the cathode.
A cable gland for an electric cable, the cable gland comprising a diaphragm seal (101;201;301;401;501;601;701;801) within the gland wherein, in use, an electric cable extends through the diaphragm seal, characterised in that the diaphragm seal comprises an inner seal wall (103;203;303;403;503;603;703;803) which defines a through bore for the passage of a cable, and an outer seal wall (105;205;305;405;505;605;705;805) in the gland with a diaphragm (107;207;307;407;507;607;707;807) extending between the inner and outer seal walls, wherein, the inner and outer seal walls are generally cylindrical and are concentric about a central longitudinal axis of the gland, with the outer seal wall having a greater diameter than the inner seal wall, and wherein the diaphragm seal is provided with a plurality of integral support portions (123;223;323;423;523) in the form of a series of webs (125;225;325;481) circumferentially spaced apart around the longitudinal axis on the cable exit side of the diaphragm or in the form of a series of annular ribs arranged concentrically about the longitudinal axis on the cable exit side of the diaphragm.
A MEMS device comprising: a substrate; a fixed electrode that is provided on the substrate and allows a signal to pass therethrough; a movable electrode that is provided above the substrate in a manner to face the fixed electrode and allows a signal to pass therethrough; a driving line that is provided inside the substrate and used to apply a driving voltage to displace the movable electrode; and a first resistance (RVa; RVd, RVe) that is provided in a first via hole formed inside the substrate and used to cutoff a signal, wherein: a) the fixed electrode or the movable electrode is connected to the driving line through the first resistance (RVa); or b) the MEMS device comprises a driving electrode (21a, 21b) that is provided on the substrate in a manner to face the movable electrode and connected to the driving line through the first resistance (RVd, RVe). a substrate; a fixed electrode that is provided on the substrate and allows a signal to pass therethrough; a movable electrode that is provided above the substrate in a manner to face the fixed electrode and allows a signal to pass therethrough; a driving line that is provided inside the substrate and used to apply a driving voltage to displace the movable electrode; and a first resistance (RVa; RVd, RVe) that is provided in a first via hole formed inside the substrate and used to cutoff a signal, wherein: a) the fixed electrode or the movable electrode is connected to the driving line through the first resistance (RVa); or b) the MEMS device comprises a driving electrode (21a, 21b) that is provided on the substrate in a manner to face the movable electrode and connected to the driving line through the first resistance (RVd, RVe). a) the fixed electrode or the movable electrode is connected to the driving line through the first resistance (RVa); or b) the MEMS device comprises a driving electrode (21a, 21b) that is provided on the substrate in a manner to face the movable electrode and connected to the driving line through the first resistance (RVd, RVe).
A pharmaceutical composition comprising a monoclonal antibody to human CEACAM1; and a pharmaceutical composition comprising a monoclonal antibody to human PD-1 for use in treatment of cancer by separate sequential administration one after the other; wherein said monoclonal antibody is capable of inhibiting or blocking the interaction between human PD-1 and its ligands; and wherein said monoclonal antibody to human CEACAM1 has: a heavy-chain CDR1 comprising a sequence set forth in SEQ ID NO: 1, a heavy-chain CDR2 comprising a sequence set forth in SEQ ID NO: 2, a heavy-chain CDR3 comprising a sequence set forth in SEQ ID NO: 3, a light-chain CDR1 comprising a sequence set forth in SEQ ID NO: 4, a light-chain CDR2 comprising a sequence set forth in SEQ ID NO: 5, and a light-chain CDR3 comprising a sequence set forth in SEQ ID NO: 6, a heavy-chain CDR1 comprising a sequence set forth in SEQ ID NO: 1, a heavy-chain CDR2 comprising a sequence set forth in SEQ ID NO: 2, a heavy-chain CDR3 comprising a sequence set forth in SEQ ID NO: 3, a light-chain CDR1 comprising a sequence set forth in SEQ ID NO: 4, a light-chain CDR2 comprising a sequence set forth in SEQ ID NO: 5, and a light-chain CDR3 comprising a sequence set forth in SEQ ID NO: 6,
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and an acetaminophen dimer compound having Formula: or a pharmaceutically acceptable salt or solvate thereof, for use in treating pain or fever in a patient in need thereof and having a risk of hepatotoxicity if administered an acetaminophen monomer; optionally wherein: (a) the fever is non-infectious fever or infectious fever; or (b) the acute or chronic pain is accompanied by non-infectious fever or infectious fever. (a) the fever is non-infectious fever or infectious fever; or (b) the acute or chronic pain is accompanied by non-infectious fever or infectious fever.
An RFID tag part, for example for an ear tag, comprising at least a housing, a transponder, a washer, and a cover, wherein said transponder and said washer are housed in said housing between said housing and said cover, said washer is positioned between said transponder and said cover and comprises means to maintain said transponder in said housing, and said washer is a separate entity to that of the transponder and the cover.