mhurhangee/ep-ind-claims huggingface dataset:
A combination of an allosteric mTOR inhibitor and a catalytic mTOR inhibitor for use in the treatment or prevention of a neurodegenerative disease selected from Huntington's Disease, Parkinson's disease, spinocerebellar ataxia type 3, Alzheimer's disease and motor neuron disease wherein the allosteric mTOR inhibitor is RAD001 and the catalytic mTOR inhibitor is BEZ235 or CCG168; wherein RAD001 has the following chemical name and structure: (1R,9S,12S,15R, 16E, 18R, 19R, 21R, 23S, 24E, 26E, 28E, 30S, 32S, 35R)-1,18-dihydroxy-12-{ -2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.0 4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone BEZ235 has the following chemical name and structure: 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile and CCG168 has the following chemical name and structure: {5-[2,4-bis-( -3-methyl-morpholin-4-yl)-pyrido[2,3d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol (1R,9S,12S,15R, 16E, 18R, 19R, 21R, 23S, 24E, 26E, 28E, 30S, 32S, 35R)-1,18-dihydroxy-12-{ -2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.0 4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
An apparatus for audio fingerprinting, comprising: a frequency range separator to transform an audio signal into a frequency domain (300, 308, 310, 400), the transformed audio signal including a plurality of time-frequency bins (304A, 304B) including a first time-frequency bin (304A, 304B); an audio characteristic determiner to determine a first characteristic of a first group (306A, 306B, 412A, 412B) of time-frequency bins of the plurality of time-frequency bins, the first group of time-frequency bins surrounding the first time-frequency bin; a signal normalizer to normalize the audio signal to thereby generate normalized energy values (302, 500, 502, 600, 602), the normalizing of the audio signal including normalizing the first time-frequency bin by the first characteristic; a point selector to: select one of the normalized energy values (302, 500, 502); determine a category of the audio signal; and weigh the selecting of the one of the normalized energy values by the category of the audio signal; and a fingerprint generator to generate a fingerprint of the audio signal using the selected one of the normalized energy values. a frequency range separator to transform an audio signal into a frequency domain (300, 308, 310, 400), the transformed audio signal including a plurality of time-frequency bins (304A, 304B) including a first time-frequency bin (304A, 304B); an audio characteristic determiner to determine a first characteristic of a first group (306A, 306B, 412A, 412B) of time-frequency bins of the plurality of time-frequency bins, the first group of time-frequency bins surrounding the first time-frequency bin; a signal normalizer to normalize the audio signal to thereby generate normalized energy values (302, 500, 502, 600, 602), the normalizing of the audio signal including normalizing the first time-frequency bin by the first characteristic; a point selector to: select one of the normalized energy values (302, 500, 502); determine a category of the audio signal; and weigh the selecting of the one of the normalized energy values by the category of the audio signal; and select one of the normalized energy values (302, 500, 502); determine a category of the audio signal; and weigh the selecting of the one of the normalized energy values by the category of the audio signal; and a fingerprint generator to generate a fingerprint of the audio signal using the selected one of the normalized energy values.
A dual-comb generation system comprising: a bidirectional mode-locked femtosecond laser configured to generate two laser outputs (120 and 130); a rotation stage having a rotational speed of 10,000 rpm or more; wherein the bi-directional mode-locked femtosecond laser is placed on the rotation stage and the Sagnac effect creates a repetition rate difference between the two laser outputs (120, 130) in a clockwise direction and a counterclockwise direction, and the rotation stage is coupled to a pump diode; and a fiber coupler configured to combine the two laser outputs. a bidirectional mode-locked femtosecond laser configured to generate two laser outputs (120 and 130); a rotation stage having a rotational speed of 10,000 rpm or more; wherein the bi-directional mode-locked femtosecond laser is placed on the rotation stage and the Sagnac effect creates a repetition rate difference between the two laser outputs (120, 130) in a clockwise direction and a counterclockwise direction, and the rotation stage is coupled to a pump diode; and a fiber coupler configured to combine the two laser outputs.
Filling machine (1, 1') for filling packages with fluid products, with a continuously circulating transport device for transporting the packages through the filling machine (1, 1') comprising a plurality of cells for receiving the packages, wherein a supply device for supplying packages to be filled is assigned to a supply region of the transport device and a discharge device for discharging the packages is assigned to a discharge region of the transport device, wherein in the transport direction of the transport device a filling region is provided between the supply region and the discharge region and a return region is provided between the discharge region and the supply region in each case of the transport device and wherein at least one nozzle (38, 38') for spraying the cells with a cleaning fluid is assigned to the return region of the transport device and wherein a splash board for collecting and draining cleaning fluid sprayed by the nozzle (38, 38') and passing the cells is arranged on the side of the transport device facing away from the at least one nozzle (38, 38') and opposite the nozzle (38, 38') characterised in that the at least one nozzle (38, 38') and the at least one splash board are assigned to a deviation region of the transport device.
A supplemental oxygen delivery system for delivery of supplemental oxygen from an oxygen supply to a patient, the delivery system comprising: a housing defining a chamber through which supplemental oxygen is led, the housing having an inlet for supplemental oxygen supply into the chamber and an outlet; an aerosol generator mounted to the housing for delivery of aerosol into the chamber, the aerosol generator comprising an aerosol outlet which is located in the housing intermediate the housing inlet and the housing outlet; a delivery tube for delivery of supplemental oxygen containing an aerosol from the housing outlet; wherein the housing is adapted to retain larger aerosol particles in the housing and comprises means (25, 26) to encourage localised deposition of larger particles; the volumetric mean diameter of the aerosol particles at the outlet of the housing being less than the volumetric mean diameter of particles generated by the aerosol generator; and the volumetric mean diameter of the aerosol particles at the outlet of the housing being less than 4.5 microns. a housing defining a chamber through which supplemental oxygen is led, the housing having an inlet for supplemental oxygen supply into the chamber and an outlet; an aerosol generator mounted to the housing for delivery of aerosol into the chamber, the aerosol generator comprising an aerosol outlet which is located in the housing intermediate the housing inlet and the housing outlet; a delivery tube for delivery of supplemental oxygen containing an aerosol from the housing outlet; wherein the housing is adapted to retain larger aerosol particles in the housing and comprises means (25, 26) to encourage localised deposition of larger particles; the volumetric mean diameter of the aerosol particles at the outlet of the housing being less than the volumetric mean diameter of particles generated by the aerosol generator; and the volumetric mean diameter of the aerosol particles at the outlet of the housing being less than 4.5 microns.
An unmanned underwater vehicle 'UUV', comprising: a body; and a propulsion system for propelling and orienting the UUV, the propulsion system comprising: an inlet formed in the body that facilitates fluid being drawn into the UUV from outside the body, a duct in fluid communication with the inlet, the duct being adapted to direct the fluid along a flow path, a pump operable with the duct to increase the velocity of the fluid, and a nozzle in fluid communication with the duct to receive the fluid at the increased velocity, the nozzle being supported about a side of the body, and adapted to moveably redirect fluid out of the UUV, wherein the nozzle is rotationally supported for rotation about an axis substantially perpendicular to a longitudinal axis of the body, and can rotate a full 360 degrees about the axis substantially perpendicular to the longitudinal axis of the body, wherein the propulsion system provides multi-axis control of the UUV, and wherein the nozzle is countersunk below an outer profile of the body. a body; and a propulsion system for propelling and orienting the UUV, the propulsion system comprising: an inlet formed in the body that facilitates fluid being drawn into the UUV from outside the body, a duct in fluid communication with the inlet, the duct being adapted to direct the fluid along a flow path, a pump operable with the duct to increase the velocity of the fluid, and a nozzle in fluid communication with the duct to receive the fluid at the increased velocity, the nozzle being supported about a side of the body, and adapted to moveably redirect fluid out of the UUV, wherein the nozzle is rotationally supported for rotation about an axis substantially perpendicular to a longitudinal axis of the body, and can rotate a full 360 degrees about the axis substantially perpendicular to the longitudinal axis of the body, wherein the propulsion system provides multi-axis control of the UUV, and an inlet formed in the body that facilitates fluid being drawn into the UUV from outside the body, a duct in fluid communication with the inlet, the duct being adapted to direct the fluid along a flow path, a pump operable with the duct to increase the velocity of the fluid, and a nozzle in fluid communication with the duct to receive the fluid at the increased velocity, the nozzle being supported about a side of the body, and adapted to moveably redirect fluid out of the UUV, wherein the nozzle is rotationally supported for rotation about an axis substantially perpendicular to a longitudinal axis of the body, and can rotate a full 360 degrees about the axis substantially perpendicular to the longitudinal axis of the body, wherein the propulsion system provides multi-axis control of the UUV, and wherein the nozzle is countersunk below an outer profile of the body.
A blood sugar management device including a blood sugar information acquisition unit configured to acquire blood sugar information including a measured value, and a meal information acquisition unit configured to acquire meal information including a meal image of a subject, the blood sugar management device comprising: a storage unit configured to store the blood sugar information and the meal information; a blood sugar determination unit configured to determine whether or not the measured value is within a predetermined range; and an information organization unit configured to organize the meal information stored in the storage unit, wherein, based on determination of the blood sugar determination unit, when the blood sugar determination unit determines that the measured value is within the predetermined range, the information organization unit deletes meal information corresponding to the measured value from the storage unit, and when the blood sugar determination unit determines that the measured value is not within the predetermined range, the information organization unit holds meal information corresponding to the measured value in the storage unit. a storage unit configured to store the blood sugar information and the meal information; a blood sugar determination unit configured to determine whether or not the measured value is within a predetermined range; and an information organization unit configured to organize the meal information stored in the storage unit, wherein, based on determination of the blood sugar determination unit, when the blood sugar determination unit determines that the measured value is within the predetermined range, the information organization unit deletes meal information corresponding to the measured value from the storage unit, and when the blood sugar determination unit determines that the measured value is not within the predetermined range, the information organization unit holds meal information corresponding to the measured value in the storage unit.
A vacuum cleaner comprising: a case having a suction port; a drum brush rotatably provided in the case to sweep and guide foreign matter to the suction port; a dust removal unit provided in the case so that the dust removal unit is rotatably moved between a first position where a side of the dust removal unit contacts the drum brush and a second position where the side of the dust removal unit is separated from the drum brush; and a lever connected to the dust removal unit to move the dust removal unit from the second position to the first position, characterized in that the dust removal unit comprises a body and a dusting part extending from the body so that the dusting part contacts the drum brush at the first position and is separated from the drum brush at the second position, and wherein one side of the lever forms an extension part coupled to the case, and the other side of the lever is connected to the body, and an actuating unit is coupled to the case and configured to be moved between an actuating position at which the extension part is pressed and a releasing position at which the extension part is released. a case having a suction port; a drum brush rotatably provided in the case to sweep and guide foreign matter to the suction port; a dust removal unit provided in the case so that the dust removal unit is rotatably moved between a first position where a side of the dust removal unit contacts the drum brush and a second position where the side of the dust removal unit is separated from the drum brush; and a lever connected to the dust removal unit to move the dust removal unit from the second position to the first position, characterized in that the dust removal unit comprises a body and a dusting part extending from the body so that the dusting part contacts the drum brush at the first position and is separated from the drum brush at the second position, and wherein one side of the lever forms an extension part coupled to the case, and the other side of the lever is connected to the body, and an actuating unit is coupled to the case and configured to be moved between an actuating position at which the extension part is pressed and a releasing position at which the extension part is released.
Display device comprising at least one light source as lighting unit and at least one chassis, comprising; - at least one heat dissipation plate, wherein said light source is in communication for heat transfer with said heat dissipation plate, wherein the heat dissipation plate is connected to said chassis so as to dissipate the heat generated by the light source through the chassis, said light source is placed at the at least one corner of the display device, characterized in that: the thermal conductivity of the heat dissipation plate is higher than 200W/mk, wherein said heat dissipation plate extends along one edge of the display device, and wherein at least one additional heat sink is located between the heat dissipation plate and the chassis. - at least one heat dissipation plate, wherein said light source is in communication for heat transfer with said heat dissipation plate, wherein the heat dissipation plate is connected to said chassis so as to dissipate the heat generated by the light source through the chassis, said light source is placed at the at least one corner of the display device, characterized in that: the thermal conductivity of the heat dissipation plate is higher than 200W/mk, wherein said heat dissipation plate extends along one edge of the display device, and wherein at least one additional heat sink is located between the heat dissipation plate and the chassis.
Equipment for processing items intended for commercial and non-commercial distribution, said equipment comprising a conveyor belt for transporting and/or moving said items, identification means for identifying each of said items, means for generating an individual label for each of said items, as well as means for applying individually each of the said individual labels onto the associated or corresponding item, said equipment being configured so that said individual labels are generated by said means for generating said individual labels each depending on the identification data of the associated or corresponding item, acquired by the said identification means, characterised by comprising tracking means able to track the path of at least one portion of each of said items, the sequence of said items being entirely random, said equipment being further configured so that said individual labels are applied by said means for applying the individual labels each onto the said portion of the associated or corresponding item on the basis of the path data of the said associated or corresponding item and wherein the said tracking means comprise recognition means able to recognize at least one marker applied to or already present on each of said items and track the path of each of said markers wherein the means for applying the individual labels are configured to apply the label on the marker.
A process for producing a dilute fabric conditioner, the fabric conditioner comprising: a. 0.5 to 4 wt. % quaternary ammonium fabric softening active; b. 0.1 to 4 wt. % perfume microcapsules; and c. 0.01 to 4 wt. % cationic polymer; the process comprising the steps of: i. Dispersing the perfume microcapsules in water; ii. Add the fabric softening active; and iii. Adding the polymer. a. 0.5 to 4 wt. % quaternary ammonium fabric softening active; b. 0.1 to 4 wt. % perfume microcapsules; and c. 0.01 to 4 wt. % cationic polymer; i. Dispersing the perfume microcapsules in water; ii. Add the fabric softening active; and iii. Adding the polymer.
Method for determining corrected acquisition geometries of projection images of a projection image dataset, comprising the following steps: - Providing a projection image dataset which comprises a plurality of projection images of an object under examination that have been acquired by an acquisition device in different acquisition geometries, - Determining a provisional acquisition geometry for each of the projection images by means of a first optimisation method by minimising a first cost function by varying the provisional acquisition geometry, wherein the first cost function is contingent on a plurality of consistency measures which are determined on the basis of the provisional acquisition geometry for a respective pair of projection images, and - Determining the respective corrected acquisition geometry for each of the projection images by means of a second optimisation method by minimising a second cost function by varying the corrected acquisition geometries, wherein the second cost function is contingent on a measure for an image quality of image data reconstructed on the basis of the projection images and the corrected acquisition geometries, wherein, in a first iteration step of the second optimisation method, the provisional acquisition geometries determined by the first optimisation method are used as corrected acquisition geometries. - Providing a projection image dataset which comprises a plurality of projection images of an object under examination that have been acquired by an acquisition device in different acquisition geometries, - Determining a provisional acquisition geometry for each of the projection images by means of a first optimisation method by minimising a first cost function by varying the provisional acquisition geometry, wherein the first cost function is contingent on a plurality of consistency measures which are determined on the basis of the provisional acquisition geometry for a respective pair of projection images, and - Determining the respective corrected acquisition geometry for each of the projection images by means of a second optimisation method by minimising a second cost function by varying the corrected acquisition geometries, wherein the second cost function is contingent on a measure for an image quality of image data reconstructed on the basis of the projection images and the corrected acquisition geometries, wherein, in a first iteration step of the second optimisation method, the provisional acquisition geometries determined by the first optimisation method are used as corrected acquisition geometries.
Process for synthesizing a compound corresponding to the formula [Chem I] in which R1 and R2 represent, independently of each other, a group chosen from: -SO 3 H and - SO 3 -, R3 represents a group chosen from: -OH, -OR', -OCOOR', where R' represents a C 1 -C 8 alkyl, a C 1 -C 8 alkenyl, a phenyl or a benzyl, R4 and R5, which may be identical or different, represent a group chosen from: a C 1 -C 8 alkyl, a C 1 -C 8 alkenyl, a phenyl or a benzyl, it being understood that two groups R4 and R5 borne by the same nitrogen atom may together form a ring including said nitrogen atom, Y represents an organic or inorganic cation chosen from pharmaceutically acceptable salts; t represents a number, t = 0; 1/2; 1; this process comprising at least the following steps: a) condensing the benzaldehyde compound of the formula [Chem II] with the dialkylaniline of the formula [Chem III] to give the triphenylmethane of the formula [Chem IV], in which R3, R4 and R5 have the same definition as in the formula [Chem I] b) treating the triphenylmethane of the formula [Chem IV] with sulfuric acid to form the triphenylmethane sulfone of the formula [Chem V] in which R1, R2, R3, R4 and R5 have the same definition as in the formula [Chem I] c) oxidizing the triphenylmethane sulfone of the formula [Chem V] with a quinone. R1 and R2 represent, independently of each other, a group chosen from: -SO 3 H and - SO 3 -, R3 represents a group chosen from: -OH, -OR', -OCOOR', where R' represents a C 1 -C 8 alkyl, a C 1 -C 8 alkenyl, a phenyl or a benzyl, R4 and R5, which may be identical or different, represent a group chosen from: a C 1 -C 8 alkyl, a C 1 -C 8 alkenyl, a phenyl or a benzyl, it being understood that two groups R4 and R5 borne by the same nitrogen atom may together form a ring including said nitrogen atom, Y represents an organic or inorganic cation chosen from pharmaceutically acceptable salts; t represents a number, t = 0; 1/2; 1; this process comprising at least the following steps: a) condensing the benzaldehyde compound of the formula [Chem II] with the dialkylaniline of the formula [Chem III] to give the triphenylmethane of the formula [Chem IV], in which R3, R4 and R5 have the same definition as in the formula [Chem I] b) treating the triphenylmethane of the formula [Chem IV] with sulfuric acid to form the triphenylmethane sulfone of the formula [Chem V] in which R1, R2, R3, R4 and R5 have the same definition as in the formula [Chem I] c) oxidizing the triphenylmethane sulfone of the formula [Chem V] with a quinone. a) condensing the benzaldehyde compound of the formula [Chem II] with the dialkylaniline of the formula [Chem III] to give the triphenylmethane of the formula [Chem IV], in which R3, R4 and R5 have the same definition as in the formula [Chem I] b) treating the triphenylmethane of the formula [Chem IV] with sulfuric acid to form the triphenylmethane sulfone of the formula [Chem V] in which R1, R2, R3, R4 and R5 have the same definition as in the formula [Chem I] c) oxidizing the triphenylmethane sulfone of the formula [Chem V] with a quinone.