A compound represented by formula (I-1), a pharmaceutically acceptable salt thereof or an isomer thereof, wherein the isomer is a stereoisomer, wherein, T 1 is N or CR 1; T 2 is N or CR 2; T 3 is N or CR 3; R 1, R 2 and R 3 are each independently H, F, Cl, Br, CN, -OR a, -C(=O)NR b R c or C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, -OCH 3, -CN, -NH 2, -NO 2 or 5-membered heterocycloalkyl; or, R 2 and R 3 with the carbon atoms to which they are attached are linked together so that the moiety R 4, R 5, R 6 and R 7 are each independently H, F, Cl, Br, CN, -OR a, -C(=O)NR b R c, -NR d R e, C 1-6 alkyl or C 3-6 cycloalkyl, wherein the C 1-6 alkyl and C 3-6 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, - OCH 3, -CN, -NH 2, -NO 2 or C 1-4 alkyl; R 8 and R 9 are each independently H, C 1-6 alkyl, or R 8 and R 9 together with the carbon atom to which they are attached form a 5- to 6-membered heterocycloalkyl, wherein the C 1-6 alkyl and 5- to 6-membered heterocycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, CN, -OR a or -NR d R e; each of R 10 is independently F, Cl, Br, CN, -OR a, C 1-6 alkyl or C 3-6 cycloalkyl, wherein the C 1-6 alkyl and C 3-6 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, -OCH 3, -CN, -NH 2, -NO 2 or C 1-4 alkyl; R a, R b and R c are each independently H, C 1-6 alkyl or C 3-4 cycloalkyl, wherein the C 1-6 alkyl and C 3-4 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, -OH, -OCH 3, -CN, -NH 2 or -NO 2; R d and R e are each independently H, C 1-6 alkyl, -S(=O) 2 C 1-3 alkyl, or R d and R e together with the N atom to which they are attached form a 4- to 8-membered heterocycloalkyl, wherein the C 1-6 alkyl and 4- to 8-membered heterocycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, -OH, -OCH 3, -CN, - NH 2, C 1-6 alkylamino or -NO 2; n is 0, 1, 2, 3 or 4; the 5-membered heterocycloalkyl, 5- to 6-membered heterocycloalkyl and 4- to 8-membered heterocycloalkyl contains 1, 2, 3 or 4 heteroatoms or heteroatomic groups independently selected from N, -O-, -S- and -NH-. T 1 is N or CR 1; T 2 is N or CR 2; T 3 is N or CR 3; R 1, R 2 and R 3 are each independently H, F, Cl, Br, CN, -OR a, -C(=O)NR b R c or C 1-6 alkyl, wherein the C 1-6 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, -OCH 3, -CN, -NH 2, -NO 2 or 5-membered heterocycloalkyl; or, R 2 and R 3 with the carbon atoms to which they are attached are linked together so that the moiety R 4, R 5, R 6 and R 7 are each independently H, F, Cl, Br, CN, -OR a, -C(=O)NR b R c, -NR d R e, C 1-6 alkyl or C 3-6 cycloalkyl, wherein the C 1-6 alkyl and C 3-6 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, - OCH 3, -CN, -NH 2, -NO 2 or C 1-4 alkyl; R 8 and R 9 are each independently H, C 1-6 alkyl, or R 8 and R 9 together with the carbon atom to which they are attached form a 5- to 6-membered heterocycloalkyl, wherein the C 1-6 alkyl and 5- to 6-membered heterocycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, CN, -OR a or -NR d R e; each of R 10 is independently F, Cl, Br, CN, -OR a, C 1-6 alkyl or C 3-6 cycloalkyl, wherein the C 1-6 alkyl and C 3-6 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, I, -OH, -OCH 3, -CN, -NH 2, -NO 2 or C 1-4 alkyl; R a, R b and R c are each independently H, C 1-6 alkyl or C 3-4 cycloalkyl, wherein the C 1-6 alkyl and C 3-4 cycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, -OH, -OCH 3, -CN, -NH 2 or -NO 2; R d and R e are each independently H, C 1-6 alkyl, -S(=O) 2 C 1-3 alkyl, or R d and R e together with the N atom to which they are attached form a 4- to 8-membered heterocycloalkyl, wherein the C 1-6 alkyl and 4- to 8-membered heterocycloalkyl are optionally substituted by 1, 2 or 3 substituents independently selected from F, Cl, Br, -OH, -OCH 3, -CN, - NH 2, C 1-6 alkylamino or -NO 2; n is 0, 1, 2, 3 or 4; the 5-membered heterocycloalkyl, 5- to 6-membered heterocycloalkyl and 4- to 8-membered heterocycloalkyl contains 1, 2, 3 or 4 heteroatoms or heteroatomic groups independently selected from N, -O-, -S- and -NH-.