Amphiphilic dendrimer having an hydrophilic terminal group at the end of each generation chain, wherein the hydrophilic terminal group comprises: - a mono-, oligo- or polysaccharide residue, - a cyclodextrin residue, - a polyethylene glycol residue, - a peptide residue, - a tris(hydroxymethyl)aminoethane (Tris), or - a 2-amino-2-methylpropane-1,3-diol; and having the following formula: wherein: W is R F or a group selected from: R F being a C 4 -C 10 perfluoroalkyl or a C 1 -C 24 alkyl group and R H being a C 1 -C 24 alkyl group, p is 0, 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; Z is NH or NH; R 1, R 2, R 3 are H, or a group selected from (c) or (d): provided that: R 1, R 2, R 3 are the same and selected from either group (c) or (d) or one of R 1, R 2, R 3 is H, the two others being the same and selected from either group (c) or (d); X is X a when j is 1 and X b when j is 0; X a is at each occurrence independently selected from -OC(=O)CH 2 -NH-,-OC(=O)CH 2 -O-CH 2 -, -O(CH 2) r C(=O)-NH-, -O(CH 2) r C(=O)-O-CH 2; Y a is independently selected from: X b is Y b is independently selected from: Vis R 4, R 7 are each independently selected from H, C 1 -C 6 alkyl and CH 2 OR 10; R 5 is selected from H and C 1 -C 6 alkyl; R 6 is a mono-, oligo-, polysaccharide or a cyclodextrin residue; R 8, R 9 are each independently a peptide residue; R 10 is H or a monosacchraide selected from glucose, galactose, mannose; i is 0 or 1; j is 0 or 1; e is 0, 1, 2, 3 or 4; k is an integer fron 1 to 12, preferably 1, 2, 3, 4, or 5; r is an integer from 1 to 10; u is 0, 1, 2, 3 or 4; v is 1, 2, or 3; w is an integer from 1 to 20, preferably from 1 to 10; x is an integer from 1 to 30, preferably from 5 to 15; y, z are each independently an integer from 1 to 6; - a mono-, oligo- or polysaccharide residue, - a cyclodextrin residue, - a polyethylene glycol residue, - a peptide residue, - a tris(hydroxymethyl)aminoethane (Tris), or - a 2-amino-2-methylpropane-1,3-diol; W is R F or a group selected from: R F being a C 4 -C 10 perfluoroalkyl or a C 1 -C 24 alkyl group and R H being a C 1 -C 24 alkyl group, p is 0, 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; Z is NH or NH; R 1, R 2, R 3 are H, or a group selected from (c) or (d): R 1, R 2, R 3 are the same and selected from either group (c) or (d) or one of R 1, R 2, R 3 is H, the two others being the same and selected from either group (c) or (d); X is X a when j is 1 and X b when j is 0; X a is at each occurrence independently selected from -OC(=O)CH 2 -NH-,-OC(=O)CH 2 -O-CH 2 -, -O(CH 2) r C(=O)-NH-, -O(CH 2) r C(=O)-O-CH 2; Y a is independently selected from: X b is Y b is independently selected from: Vis R 4, R 7 are each independently selected from H, C 1 -C 6 alkyl and CH 2 OR 10; R 5 is selected from H and C 1 -C 6 alkyl; R 6 is a mono-, oligo-, polysaccharide or a cyclodextrin residue; R 8, R 9 are each independently a peptide residue; R 10 is H or a monosacchraide selected from glucose, galactose, mannose; i is 0 or 1; j is 0 or 1; e is 0, 1, 2, 3 or 4; k is an integer fron 1 to 12, preferably 1, 2, 3, 4, or 5; r is an integer from 1 to 10; u is 0, 1, 2, 3 or 4; v is 1, 2, or 3; w is an integer from 1 to 20, preferably from 1 to 10; x is an integer from 1 to 30, preferably from 5 to 15; y, z are each independently an integer from 1 to 6;