A hand-held laser treatment device, comprising: a housing including a distal head region; a first laser source configured to facilitate the emission of a first laser beam having a first beam characteristic; a second laser source configured to facilitate the emission of a second laser beam having a second beam characteristic differing from the first beam characteristic; a temperature sensor configured to function as a safety feature to actively monitor the temperature of the device resulting from the operation of one or both of the first and second laser sources; a laser transmission path configured to facilitate the transmission of one or both of the first and second laser beams from the treatment device, the laser transmission path comprising a plurality of discrete segments which are of prescribed lengths and a plurality of ancillary transmission components which are integrated into the segments at prescribed spatial relationships and angular orientations relative to each other and to the first and second laser sources; the plurality of ancillary transmission components including an elongate coupling fiber, a focusing mirror positioned in the distal head region and a delivery tip protruding from at least a portion of the housing, wherein the focusing mirror is configured to direct the first and/or second laser beams transmitted thereto from an output end of the coupling fiber to an input end of the delivery tip, wherein an angle between a delivery axis of the delivery tip and a portion of an axis, the axis being defined by a segment of the plurality of discrete segments of the laser transmission path and the portion of said axis extending between the output end of the coupling fiber and the focusing mirror, is 90°; and wherein the lengths of the segments, angular orientations, and spatial relationships of the components relative to each other and to each of the first and second laser sources are configured and arranged to enable the first and second beam characteristics of the first and second laser beams to be combined within one of the segments of the laser transmission path forming coincident transmission of the first and second laser beams from the treatment device. a housing including a distal head region; a first laser source configured to facilitate the emission of a first laser beam having a first beam characteristic; a second laser source configured to facilitate the emission of a second laser beam having a second beam characteristic differing from the first beam characteristic; a temperature sensor configured to function as a safety feature to actively monitor the temperature of the device resulting from the operation of one or both of the first and second laser sources; a laser transmission path configured to facilitate the transmission of one or both of the first and second laser beams from the treatment device, the laser transmission path comprising a plurality of discrete segments which are of prescribed lengths and a plurality of ancillary transmission components which are integrated into the segments at prescribed spatial relationships and angular orientations relative to each other and to the first and second laser sources; the plurality of ancillary transmission components including an elongate coupling fiber, a focusing mirror positioned in the distal head region and a delivery tip protruding from at least a portion of the housing, wherein the focusing mirror is configured to direct the first and/or second laser beams transmitted thereto from an output end of the coupling fiber to an input end of the delivery tip, wherein an angle between a delivery axis of the delivery tip and a portion of an axis, the axis being defined by a segment of the plurality of discrete segments of the laser transmission path and the portion of said axis extending between the output end of the coupling fiber and the focusing mirror, is 90°; and wherein the lengths of the segments, angular orientations, and spatial relationships of the components relative to each other and to each of the first and second laser sources are configured and arranged to enable the first and second beam characteristics of the first and second laser beams to be combined within one of the segments of the laser transmission path forming coincident transmission of the first and second laser beams from the treatment device.