A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein: each R 1 and R 2 is independently H, F, or Cl; G 2 is selected from: or G 5 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, cyano, -CH 2 OH, OPh, or - SO 2 (C 1 -C 3 alkyl); G 5a is hydrogen or methyl; G 6 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, or OPh; G 6b is hydrogen or methyl; G 7 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, OPh, COOH, or CON(G 10)(G 11); G 7a is hydrogen, methyl, or fluoro; G 8 is hydrogen, C 1 -C 4 alkyl, fluoro, chloro, phenyl, O C 1 -C 3 alkyl, OPh, COOH, cyano, - CH 2 OH, -SO 2 (C 1 -C 3 alkyl) or CON(G 10)(G 11); G 8a is hydrogen, methyl or OC 1 -C 3 alkyl; G 8b is hydrogen or fluoro; G 9 is hydrogen, C 1 -C 4 alkyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, OPh, COOH, CON(G 10)(G 11), C(CH 3) 2 CH 2 OH, or -SO 2 -morpholine; G 9a is hydrogen, C 1 -C 4 alkyl, or fluoro; G 10 is hydrogen or methyl; G 11 is hydrogen or methyl; or G 10 and G 11 are joined together form a piperidine G 12 is hydrogen or C 1 -C 3 alkyl; G 13 is hydrogen or C 1 -C 3 alkyl; G 14 is hydrogen or C 1 -C 3 alkyl; G 15 is hydrogen or C 1 -C 3 alkyl; G 16 is hydrogen or C 1 -C 3 alkyl; R is R 3 is hydrogen, Cl, or F; R 4 is hydrogen, C 1 -C 3 alkyl, or C 3 -C 6 cycloalkyl -wherein C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl is optionally substituted with 1-3 fluorines; R 5 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or NG 12 G 13; R 6 and R 7 are each independently hydrogen, chlorine, or fluorine; R 10 is hydrogen, chlorine, fluorine, -C 1 -C 3 alkyl, -SO 2 C 1 -C 3 alkyl, -SO 2 C 3 -C 6 cycloalkyl, -SO 2 NR a R b, wherein -C 1 -C 3 alkyl is optionally substituted with 1-3 fluorines or R 10 is selected from the following: R 11 is hydrogen, chlorine, or fluorine; R 12 is hydrogen, chlorine, fluorine, -C 1 -C 3 alkyl, or -C 3 -C 6 cycloalkyl, wherein -C 1 -C 3 alkyl is optionally substituted with 1-3 fluorines; R a and R b are independently H, -C 1 -C 3 alkyl, or together with the N to which they are attached form a morpholine, azetidine, pyrrolidine, piperidine, piperazine, N-Me piperazine, or is selected from the following: W is selected from: wherein R 13 is methyl optionally substituted with 1 to 3 fluorines. each R 1 and R 2 is independently H, F, or Cl; G 2 is selected from: or G 5 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, cyano, -CH 2 OH, OPh, or - SO 2 (C 1 -C 3 alkyl); G 5a is hydrogen or methyl; G 6 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, or OPh; G 6b is hydrogen or methyl; G 7 is hydrogen, methyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, OPh, COOH, or CON(G 10)(G 11); G 7a is hydrogen, methyl, or fluoro; G 8 is hydrogen, C 1 -C 4 alkyl, fluoro, chloro, phenyl, O C 1 -C 3 alkyl, OPh, COOH, cyano, - CH 2 OH, -SO 2 (C 1 -C 3 alkyl) or CON(G 10)(G 11); G 8a is hydrogen, methyl or OC 1 -C 3 alkyl; G 8b is hydrogen or fluoro; G 9 is hydrogen, C 1 -C 4 alkyl, fluoro, chloro, phenyl, OC 1 -C 3 alkyl, OPh, COOH, CON(G 10)(G 11), C(CH 3) 2 CH 2 OH, or -SO 2 -morpholine; G 9a is hydrogen, C 1 -C 4 alkyl, or fluoro; G 10 is hydrogen or methyl; G 11 is hydrogen or methyl; or G 10 and G 11 are joined together form a piperidine G 12 is hydrogen or C 1 -C 3 alkyl; G 13 is hydrogen or C 1 -C 3 alkyl; G 14 is hydrogen or C 1 -C 3 alkyl; G 15 is hydrogen or C 1 -C 3 alkyl; G 16 is hydrogen or C 1 -C 3 alkyl; R is R 3 is hydrogen, Cl, or F; R 4 is hydrogen, C 1 -C 3 alkyl, or C 3 -C 6 cycloalkyl -wherein C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl is optionally substituted with 1-3 fluorines; R 5 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or NG 12 G 13; R 6 and R 7 are each independently hydrogen, chlorine, or fluorine; R 10 is hydrogen, chlorine, fluorine, -C 1 -C 3 alkyl, -SO 2 C 1 -C 3 alkyl, -SO 2 C 3 -C 6 cycloalkyl, -SO 2 NR a R b, wherein -C 1 -C 3 alkyl is optionally substituted with 1-3 fluorines or R 10 is selected from the following: R 11 is hydrogen, chlorine, or fluorine; R 12 is hydrogen, chlorine, fluorine, -C 1 -C 3 alkyl, or -C 3 -C 6 cycloalkyl, wherein -C 1 -C 3 alkyl is optionally substituted with 1-3 fluorines; R a and R b are independently H, -C 1 -C 3 alkyl, or together with the N to which they are attached form a morpholine, azetidine, pyrrolidine, piperidine, piperazine, N-Me piperazine, or is selected from the following: W is selected from: wherein R 13 is methyl optionally substituted with 1 to 3 fluorines.