A heart valve prosthesis (20, 20A-B), comprising: a first member (22, 22A-B) configured to be advanced into a first heart chamber and comprising a first central portion to be disposed adjacent to the line of coaptation of two adjacent heart leaflets and peripheral portions to be placed into direct contact with the two adjacent heart leaflets; a second member (24, 24A-B) configured to be advanced into a second heart chamber, the two adjacent heart leaflets being disposed between the first heart chamber and the second heart chamber, the second member comprising a central portion to be disposed adjacent to the line of coaptation of the two adjacent heart leaflets and peripheral portions configured to be placed into direct contact with the two adjacent heart leaflets, the second member being separate from the first member and the first and second central portions being moveable relative to each other; and a connector (126, 50, 50A-B) configured to be disposed across a gap between the first member (22, 22A-B) and the second member (24, 24A-B) to secure the first central portion to the second central portion; characterised in that the connector comprises a locking clip (50, 50A-B) comprising an open end and a closed end, the open end configured to be advanced initially over the central portion of the second member (24, 24A-B) and subsequently over the central portion of the first member (24, 24A-B) to secure the first central portion to the second central portion, and in that the locking clip (50, 50A-B) comprises a first aperture (54, 54A, 63B) configured to receive a first guidewire (30, 30A-B) when the first guidewire is coupled with the first member. a first member (22, 22A-B) configured to be advanced into a first heart chamber and comprising a first central portion to be disposed adjacent to the line of coaptation of two adjacent heart leaflets and peripheral portions to be placed into direct contact with the two adjacent heart leaflets; a second member (24, 24A-B) configured to be advanced into a second heart chamber, the two adjacent heart leaflets being disposed between the first heart chamber and the second heart chamber, the second member comprising a central portion to be disposed adjacent to the line of coaptation of the two adjacent heart leaflets and peripheral portions configured to be placed into direct contact with the two adjacent heart leaflets, the second member being separate from the first member and the first and second central portions being moveable relative to each other; and a connector (126, 50, 50A-B) configured to be disposed across a gap between the first member (22, 22A-B) and the second member (24, 24A-B) to secure the first central portion to the second central portion; characterised in that the connector comprises a locking clip (50, 50A-B) comprising an open end and a closed end, the open end configured to be advanced initially over the central portion of the second member (24, 24A-B) and subsequently over the central portion of the first member (24, 24A-B) to secure the first central portion to the second central portion, and in that the locking clip (50, 50A-B) comprises a first aperture (54, 54A, 63B) configured to receive a first guidewire (30, 30A-B) when the first guidewire is coupled with the first member.