A method of degrading a filter cake in a subterranean formation comprising: contacting at least a portion of a filter cake with a filter cake degradation fluid comprising a relative permeability modifier, wherein the relative permeability modifier is a hydrophilically modified polymer that is a reaction product of a hydrophilic polymer selected from the group consisting of: a polyacrylamide; a polyvinylamine; a poly(vinylamine/vinyl alcohol); an alkyl acrylate polymer; a cellulose; a chitosan; a polyamide; a polyetheramine; a polyethyleneimine; a polyhydroxyetheramine; a polylysine; a polysulfone; a gum; a starch; and derivatives thereof and a hydrophilic compound selected from the group consisting of: a polyether comprising a halogen; a sulfonate; a sulfate; an organic acid; and an organic acid derivative and a solvent, wherein the solvent is an oxidizer selected from hydrogen peroxide, magnesium peroxide, magnesium peroxydiphosphate, strontium peroxide, barium peroxide, calcium peroxide, magnesium perborate, barium bromate ammonium persulfate, sodium persulfate, potassium permanganate, sodium bromate, potassium iodate, potassium periodate, sodium chlorite, sodium hypochlorite, lithium hypochlorite, calcium hypochlorite, or any combination thereof; and allowing the filter cake to degrade. contacting at least a portion of a filter cake with a filter cake degradation fluid comprising a relative permeability modifier, wherein the relative permeability modifier is a hydrophilically modified polymer that is a reaction product of a hydrophilic polymer selected from the group consisting of: a polyacrylamide; a polyvinylamine; a poly(vinylamine/vinyl alcohol); an alkyl acrylate polymer; a cellulose; a chitosan; a polyamide; a polyetheramine; a polyethyleneimine; a polyhydroxyetheramine; a polylysine; a polysulfone; a gum; a starch; and derivatives thereof and a hydrophilic compound selected from the group consisting of: a polyether comprising a halogen; a sulfonate; a sulfate; an organic acid; and an organic acid derivative and a solvent, wherein the solvent is an oxidizer selected from hydrogen peroxide, magnesium peroxide, magnesium peroxydiphosphate, strontium peroxide, barium peroxide, calcium peroxide, magnesium perborate, barium bromate ammonium persulfate, sodium persulfate, potassium permanganate, sodium bromate, potassium iodate, potassium periodate, sodium chlorite, sodium hypochlorite, lithium hypochlorite, calcium hypochlorite, or any combination thereof; a relative permeability modifier, wherein the relative permeability modifier is a hydrophilically modified polymer that is a reaction product of a hydrophilic polymer selected from the group consisting of: a polyacrylamide; a polyvinylamine; a poly(vinylamine/vinyl alcohol); an alkyl acrylate polymer; a cellulose; a chitosan; a polyamide; a polyetheramine; a polyethyleneimine; a polyhydroxyetheramine; a polylysine; a polysulfone; a gum; a starch; and derivatives thereof and a hydrophilic compound selected from the group consisting of: a polyether comprising a halogen; a sulfonate; a sulfate; an organic acid; and an organic acid derivative and a solvent, wherein the solvent is an oxidizer selected from hydrogen peroxide, magnesium peroxide, magnesium peroxydiphosphate, strontium peroxide, barium peroxide, calcium peroxide, magnesium perborate, barium bromate ammonium persulfate, sodium persulfate, potassium permanganate, sodium bromate, potassium iodate, potassium periodate, sodium chlorite, sodium hypochlorite, lithium hypochlorite, calcium hypochlorite, or any combination thereof; and allowing the filter cake to degrade.