mhurhangee/ep-ind-claims huggingface dataset:
A solid pharmaceutical composition obtainable by mixing (a) at least one active agent selected from rosuvastatin and the pharmaceutically acceptable salts thereof, (b) at least one pharmaceutically acceptable low moisture excipient having a moisture content of less than 3.0 w/w%, wherein the pharmaceutically acceptable low moisture excipient comprises non-silicified microcrystalline cellulose, and (c) optionally further excipients and compressing the obtained mixture in the absence of solvent, wherein the composition comprises at least 20 w/w% of the pharmaceutically acceptable low moisture excipient and comprises less than 0.5 w/w% of alkaline stabilizers. (a) at least one active agent selected from rosuvastatin and the pharmaceutically acceptable salts thereof, (b) at least one pharmaceutically acceptable low moisture excipient having a moisture content of less than 3.0 w/w%, wherein the pharmaceutically acceptable low moisture excipient comprises non-silicified microcrystalline cellulose, and (c) optionally further excipients
An underwater vehicle comprising: one or more buoyancy elements; a pressure tolerant cavity; and an energy system enclosed in the pressure tolerant cavity and configured to provide electrical power to the vehicle, the energy system including: one or more battery cells; and a pressure tolerant, programmable management circuit configured to manage the one or more battery cells characterized in that the pressure tolerant cavity is filled with an electrically-inert liquid. one or more buoyancy elements; a pressure tolerant cavity; and an energy system enclosed in the pressure tolerant cavity and configured to provide electrical power to the vehicle, the energy system including: one or more battery cells; and a pressure tolerant, programmable management circuit configured to manage the one or more battery cells characterized in that the pressure tolerant cavity is filled with an electrically-inert liquid. one or more battery cells; and a pressure tolerant, programmable management circuit configured to manage the one or more battery cells characterized in that the pressure tolerant cavity is filled with an electrically-inert liquid.
A lithium metal battery comprising: a lithium metal anode; a protective layer disposed on the lithium metal anode, the protective layer comprising a polymer and at least one metal salt comprising at least one element selected from Cs, Rb, K, Ba, Sr, Ca, Na and Mg, and optionally a nitrogen-containing additive; a cathode; and a liquid electrolyte disposed between the protective layer and the cathode, the liquid electrolyte comprising an organic solvent, wherein the metal salt and nitrogen-containing additive are insoluble in the organic solvent of the liquid electrolyte. a lithium metal anode; a protective layer disposed on the lithium metal anode, the protective layer comprising a polymer and at least one metal salt comprising at least one element selected from Cs, Rb, K, Ba, Sr, Ca, Na and Mg, and optionally a nitrogen-containing additive; a cathode; and a liquid electrolyte disposed between the protective layer and the cathode, the liquid electrolyte comprising an organic solvent, wherein the metal salt and nitrogen-containing additive are insoluble in the organic solvent of the liquid electrolyte.
A method for identifying one or more amino acid residues for substitution in a particular position in an immunobinder, the method comprising: a) providing a first database of V H and/or V L amino acid sequences grouped according to subtype; b) providing a second database of V H and/or V L amino acid sequences grouped according to subtype and selected as having at least one desirable functional property, wherein the desirable functional property is improved stability, improved solubility, non-aggregation, an improvement in expression, and/or an improvement in refolding yield; c) determining amino acid frequency for an amino acid residue at a framework position of the first database and at a corresponding framework position of the second database; d) determining the enrichment factor (RF2:RF1) of the amino acid by building the ratio between the relative frequency of a residue within the second database and the relative frequency of a residue within the first database e) identifying the amino acid residue (i) as a preferred amino acid residue for substitution at the corresponding amino acid position of the immunobinder when the amino acid has an enrichment factor of greater than 1, or (ii) as an amino acid residue to be excluded at the corresponding amino acid position of the immunobinder when the amino acid residue has an enrichment factor of less than 1. a) providing a first database of V H and/or V L amino acid sequences grouped according to subtype; b) providing a second database of V H and/or V L amino acid sequences grouped according to subtype and selected as having at least one desirable functional property, wherein the desirable functional property is improved stability, improved solubility, non-aggregation, an improvement in expression, and/or an improvement in refolding yield; c) determining amino acid frequency for an amino acid residue at a framework position of the first database and at a corresponding framework position of the second database; d) determining the enrichment factor (RF2:RF1) of the amino acid by building the ratio between the relative frequency of a residue within the second database and the relative frequency of a residue within the first database e) identifying the amino acid residue (i) as a preferred amino acid residue for substitution at the corresponding amino acid position of the immunobinder when the amino acid has an enrichment factor of greater than 1, or (ii) as an amino acid residue to be excluded at the corresponding amino acid position of the immunobinder when the amino acid residue has an enrichment factor of less than 1. (i) as a preferred amino acid residue for substitution at the corresponding amino acid position of the immunobinder when the amino acid has an enrichment factor of greater than 1, or (ii) as an amino acid residue to be excluded at the corresponding amino acid position of the immunobinder when the amino acid residue has an enrichment factor of less than 1.
Device for lubricating an antifriction bearing of an electric motor, comprising an oil reservoir which can be arranged on an exterior or interior of the electric motor having an oil pan and an oil delivery ring or oil delivery disk which directly or indirectly moves along on a shaft of the electric motor and runs through the oil pan, and allows oil to be transported from the oil pan into a lubrication chamber located around the shaft and adjacent to the antifriction bearing when the shaft rotates, • wherein one or a number of openings, through which oil can flow back out of the lubrication chamber into the oil pan, are provided in a radial outer wall of the lubrication chamber, • wherein an outer centrifugal disk is arranged on the shaft adjacent to the lubrication chamber in the axial direction away from the electric motor and wherein an inner centrifugal disk is arranged on the shaft in the axial direction toward the electric motor and • wherein the outer centrifugal disk and the inner centrifugal disk each have a peripheral groove (10.1, 12.1) on a side facing the lubrication chamber, the cross-section of which in the direction of a radial exterior of the respective centrifugal disk (10, 12) has a smaller radius than in the direction of a radial interior of the respective centrifugal disk (10, 12). • wherein one or a number of openings, through which oil can flow back out of the lubrication chamber into the oil pan, are provided in a radial outer wall of the lubrication chamber, • wherein an outer centrifugal disk is arranged on the shaft adjacent to the lubrication chamber in the axial direction away from the electric motor and wherein an inner centrifugal disk is arranged on the shaft in the axial direction toward the electric motor and • wherein the outer centrifugal disk and the inner centrifugal disk each have a peripheral groove (10.1, 12.1) on a side facing the lubrication chamber, the cross-section of which in the direction of a radial exterior of the respective centrifugal disk (10, 12) has a smaller radius than in the direction of a radial interior of the respective centrifugal disk (10, 12).
- Driving seat comprising a base and a back rest forming a support structure and a bearing surface for an occupant of the seat, determining a seat reference point SRP situated in a vertical axial plane of the seat at a junction of bearing surfaces of the base and of the back rest, in which seat said back rest is fixed articulated onto said base about an axis of inclination of the back rest, oriented in a direction of an axis Y at right angles to the vertical axial plane of overall symmetry of the seat, situated in a bottom part of the back rest and in a rear part of the base so as to allow a back rest inclination angle (Beta) of said back rest relative to a vertical direction Z that is adjustable, in which the back rest comprises a lower back rest panel, held on the side of a bottom edge of said lower back rest panel with a rear edge of the base so as to form the back rest inclination angle (Beta) that is modifiable, and comprises an upper back rest panel situated in the extension of and above said lower back rest panel, a raising angle (Alpha-D) of said upper back rest panel relative to said lower back rest panel being modifiable when the seat is used, characterized in that the base comprises a rear base panel, of constant fixed inclination relative to a supporting structure of the seat, substantially horizontal, and comprises a front base panel, situated in the extension and in front of said rear base panel, a base inclination angle (Alpha-A) of said front base panel relative to said rear base panel being modifiable when the seat is occupied, and in that the seat comprises: - at least one working position in which an occupant is in a seated position with the back rest straightened and the base substantially horizontal and; - at least one watchfulness position in which the occupant occupies the seat with the back rest inclined backwards and partially straightened in an upper part corresponding to the upper back rest panel and with the base raised in a front part corresponding to the front base panel. - at least one working position in which an occupant is in a seated position with the back rest straightened and the base substantially horizontal and; - at least one watchfulness position in which the occupant occupies the seat with the back rest inclined backwards and partially straightened in an upper part corresponding to the upper back rest panel and with the base raised in a front part corresponding to the front base panel.
A holding device for holding a ceramic anchor brick on a furnace wall, wherein the holding device comprises: 1.1 fastening means for fastening the holding device to a furnace wall; 1.2 a receiving part for holding a ceramic anchor brick on the holding device; 1.3 wherein the fastening means comprises a first fastening part and a second fastening part, wherein 1.3.1 the first fastening part is fastenable to a furnace wall, and 1.3.2 the second fastening part is fastened to the receiving part, and wherein 1.3.3 the second fastening part is fastenable to the first fastening part; wherein 1.4 the first fastening part and the second fastening part are designed in such a way that the second fastening part is fastenable to the first fastening part by a relative movement of the second fastening part in relation to the first fastening part; characterised in that the relative movement is a rotary movement. 1.1 fastening means for fastening the holding device to a furnace wall; 1.2 a receiving part for holding a ceramic anchor brick on the holding device; 1.3 wherein the fastening means comprises a first fastening part and a second fastening part, wherein 1.3.1 the first fastening part is fastenable to a furnace wall, and 1.3.2 the second fastening part is fastened to the receiving part, and wherein 1.3.3 the second fastening part is fastenable to the first fastening part; wherein 1.3.1 the first fastening part is fastenable to a furnace wall, and 1.3.2 the second fastening part is fastened to the receiving part, and wherein 1.3.3 the second fastening part is fastenable to the first fastening part; wherein 1.4 the first fastening part and the second fastening part are designed in such a way that the second fastening part is fastenable to the first fastening part by a relative movement of the second fastening part in relation to the first fastening part;
A computer-implemented method of analyzing microvasculatory videos for blood velocity determination, said method comprising: - receiving a sequence of microvasculatory video images, each of said video images showing a structure of vessels (2, 4, 6); - identifying vessel centerline pixels in said structure of vessels; - defining vessel segments by grouping said centerline pixels (10, 12); - automatically producing a space-time diagram for each of said vessel segments, said space-time diagram being generated at said centerline pixels associated with each of said vessel segments; - automatically estimating a blood velocity in each of said vessel segments using said space-time diagram, wherein said blood velocity in a vessel segment is estimated by: - performing a gray-scale Hough transformation H(φ,ρ), of said space-time diagram of said vessel segment, where φ is an orientation normal to that of a 2D line structure in said space-time diagram and ρ a distance of a line in said space-time diagram to an origin of said space-time diagram; - calculating a cumulative Hough diagram described by: H φ = ∑ ρ H φ ρ; - smoothing said cumulative Hough diagram: - disregarding parts of said cumulative Hough diagram that correspond to absolute blood velocities below a given threshold value v min and above v max with L the length of said vessel segment and f a video frame rate; - selecting a highest peak of said cumulative Hough diagram within an orientation range corresponding to velocities ±[ v min, v max], as being a global line orientation; - converting said global line orientation into said blood velocity. - receiving a sequence of microvasculatory video images, each of said video images showing a structure of vessels (2, 4, 6); - identifying vessel centerline pixels in said structure of vessels; - defining vessel segments by grouping said centerline pixels (10, 12); - automatically producing a space-time diagram for each of said vessel segments, said space-time diagram being generated at said centerline pixels associated with each of said vessel segments; - automatically estimating a blood velocity in each of said vessel segments using said space-time diagram, - performing a gray-scale Hough transformation H(φ,ρ), of said space-time diagram of said vessel segment, where φ is an orientation normal to that of a 2D line structure in said space-time diagram and ρ a distance of a line in said space-time diagram to an origin of said space-time diagram; - calculating a cumulative Hough diagram described by: H φ = ∑ ρ H φ ρ; - smoothing said cumulative Hough diagram: - disregarding parts of said cumulative Hough diagram that correspond to absolute blood velocities below a given threshold value v min and above v max with L the length of said vessel segment and f a video frame rate; - selecting a highest peak of said cumulative Hough diagram within an orientation range corresponding to velocities ±[ v min, v max], as being a global line orientation; - converting said global line orientation into said blood velocity.
A method for power management in a plant electrical network using one or more local controller and a central controller, the said one or more local controllers and central controller configured for power management in respective local process areas, the method comprising the steps of: a. the central controller receiving load condition information from at least one local controller in the plant electrical network or directly from an intelligent electronic device associated with the power equipment, wherein the load condition information comprises the amount of over load in a power equipment and the direction of the overload; b. the central controller performing power balance computations for the plant wide power management; c. the central controller issuing power management command based on the direction of the overload; and d. the central controller having the one or more local controller carry out load shedding in their respective local process area (110, 120, 130) based on the power management command issued. a. the central controller receiving load condition information from at least one local controller in the plant electrical network or directly from an intelligent electronic device associated with the power equipment, wherein the load condition information comprises the amount of over load in a power equipment and the direction of the overload; b. the central controller performing power balance computations for the plant wide power management; c. the central controller issuing power management command based on the direction of the overload; and d. the central controller having the one or more local controller carry out load shedding in their respective local process area (110, 120, 130) based on the power management command issued.
A pharmaceutical tablet with a first layer comprising telmisartan, and a second layer comprising hydrochlorothiazide and amlodipine, wherein the second layer comprises 10-60% mannitol, 10-50% microcrystalline cellulose and 5-25% corn starch. 10-60% mannitol, 10-50% microcrystalline cellulose and 5-25% corn starch.
A device for strip guidance in a hot medium, comprising a deflection roller which has two roller journals and is mounted by means of ceramic journal bearings (20, 31) on supporting arms (1, 2, 34), wherein the journal bearings (20, 31) are in each case arranged in a bearing receptacle of the associated supporting arm (1, 2, 34), wherein at least one of the journal bearings (20, 31) in each case in the associated supporting arm (1, 2, 34) is fixed in the bearing receptacle by means of a non-positive lock which engages on the outer edge of the journal bearing (20, 31) and compensates for different coefficients of thermal expansion of the journal bearing (20, 31) and of the bearing receptacle, wherein at least one of the journal bearings (20, 31) is fixed by means of a clamping body which engages on the journal bearing (20, 31) and on the associated supporting arm (1, 2, 34) and clamps the journal bearing (20, 31) against the wall region, lying opposite the clamping element, of the bearing receptacle of the associated supporting arm (1, 2, 34), characterized in that the clamping body has a higher coefficient of thermal expansion compared to the material of the supporting arm (1, 2, 34).
Method for producing beverage containers comprising the steps of: - delivering the plastic parisons to a transforming device; - transforming the plastic parisons into the plastic containers by means of the transforming device; - transporting the plastic containers to a filling device; - filling the plastic containers with a liquid by means of the filling device, wherein this filling device has a storage container for the liquid to be bottled; - closing the filled containers with closures, wherein a product change from first containers to be filled with a first liquid to second containers to be filled with a second liquid is carried out, and wherein for the purpose of this product change a desired quantity of the beverage containers to be filled with the first liquid is determined and a residual quantity of the first liquid to be bottled is determined, in order thus in the context of the product change to enable a most extensive consumption possible of the first liquid to be bottled, the first containers or the first container closures, wherein it is determined by the user whether the first liquid to be bottled, the first beverage containers or the first container closures are to be consumed as far as possible, wherein at least the components which are not completely consumed are discharged before the product change, wherein container closures, the containers and the liquid to be bottled are product components, characterized in that the delivery of the plastic parisons with/via a plastic parison channel to the transforming device is not interrupted during a product change, but the plastic parisons are transported seamlessly, i.e. the last "old" plastic parison of the first product is followed directly by a first new plastic parison, i.e. the first plastic parison which serves for the new product, so that during changing of the plastic parisons the plastic parison channel upstream of the transforming device is not run empty, and in this way the old plastic parisons serve as a support for the new plastic parisons, and wherein the old plastic parisons are automatically discharged in the plastic parison channel before an oven of the transforming device for heating of the plastic parisons, when they bring the new plastic parisons to the blow moulding machine. - delivering the plastic parisons to a transforming device; - transforming the plastic parisons into the plastic containers by means of the transforming device; - transporting the plastic containers to a filling device; - filling the plastic containers with a liquid by means of the filling device, wherein this filling device has a storage container for the liquid to be bottled; - closing the filled containers with closures,
Keyboard with several plate-shaped keys (13.1, 13.2, 13.2), that are each connected via an own switching pin (9.1, 9.2, 9.3) carried on a common silicon plate with an elastically deformable switching foil, wherein the silicon plate is connected with the switching foil via an adhesive foil, wherein the switching pins (9.1, 9.2, 9.3) are formed as one piece with the silicon plate, wherein electrically conductible metal domes are mounted to the switching foil that are allocated to switching contacts of a printed circuit board, wherein the switching pins (9.1, 9.2, 9.3) have switching taps, that protrude through openings of the adhesive foil and touch the switching foil at the places of the metal domes and wherein all keys (13.1, 13.2, 13.3) and all switching pins (9.1, 9.2, 9.3) allocated to these keys (13.1, 13.2, 13.3) are connected with a bending-elastical, however a predefined tensile strength owing bandlike foil.
Method for protecting against movement of a motor vehicle on an inclined ramp in a parking space, wherein, sloping away from the motor vehicle, one or more collision objects (403, 513) are moved (101, 205, 303) into a route predefined by the ramp in order to reduce a speed of the motor vehicle still on the ramp in the event of a rolling-away movement of the motor vehicle on the route through collision between one or more collision objects (403, 513) and the motor vehicle, characterized in that a fault message transmitted by the motor vehicle via a communication network is received by a communication interface, wherein the one or more collision objects (403, 513) are moved into the route by a movement apparatus (405, 515) in response to the received fault message.