mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula I wherein R 1 is selected from the group consisting of i) hydrogen, ii) halogen, and iii) C 1-6 -alkyl; R 2 is selected from the group consisting of i) hydrogen, ii) C 1-6 -alkyl, and iii) halogen-C 1-6 -alkyl; R 3 is selected from the group consisting of i) hydrogen, and ii) C 1-6 -alkyl; R 4 is selected from the group consisting of i) hydrogen, and ii) C 1-6 -alkyl; R 5 is heteroaryl unsubstituted or substituted by one or two substituents individually selected from the group consisting of i) C 1-6 -alkyl, ii) halogen, iii) C 1-6 -alkoxy, and iv) halogen-C 1-6 -alkyl, R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen; or R 6 and R 8 form together a 5-6 membered heterocyclyl, X is selected from the group consisting of i) -S, and ii) -SO 2; or pharmaceutically acceptable salts thereof. R 1 is selected from the group consisting of i) hydrogen, ii) halogen, and iii) C 1-6 -alkyl; i) hydrogen, ii) halogen, and iii) C 1-6 -alkyl; R 2 is selected from the group consisting of i) hydrogen, ii) C 1-6 -alkyl, and iii) halogen-C 1-6 -alkyl; i) hydrogen, ii) C 1-6 -alkyl, and iii) halogen-C 1-6 -alkyl; R 3 is selected from the group consisting of i) hydrogen, and ii) C 1-6 -alkyl; i) hydrogen, and ii) C 1-6 -alkyl; R 4 is selected from the group consisting of i) hydrogen, and ii) C 1-6 -alkyl; i) hydrogen, and ii) C 1-6 -alkyl; R 5 is heteroaryl unsubstituted or substituted by one or two substituents individually selected from the group consisting of i) C 1-6 -alkyl, ii) halogen, iii) C 1-6 -alkoxy, and iv) halogen-C 1-6 -alkyl, i) C 1-6 -alkyl, ii) halogen, iii) C 1-6 -alkoxy, and iv) halogen-C 1-6 -alkyl, R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen; X is selected from the group consisting of i) -S, and ii) -SO 2; i) -S, and ii) -SO 2;
An ultrasonic fluid flow meter, the meter comprising: a fluid conduit with an inlet and an outlet (5, 6), the fluid conduit bound by an inner periphery; and a first and a second ultrasonic transducer (17a, 17b) for measuring a fluid flow in the fluid conduit; wherein the first and second ultrasonic transducers (17a, 17b) are arranged in facing alignment; and wherein the first and second ultrasonic transducers (17a, 17b) are arranged within the fluid conduit spaced from said inner periphery, and wherein each of the first and second ultrasonic transducers (17a, 17b) are supported by an associated support mounting (16a, 16b), and wherein a plurality of fluid apertures (21a, 21b, 21c, 21d) are provided around each ultrasonic transducer (17a, 17b) wherein each ultrasonic transducer (17a, 17b) is provided with a flow stabiliser (15a, 15b), each flow stabilizer including a fluid deflecting element for deflecting, in use, fluid flowing in the fluid conduit around the respective ultrasonic transducer when the flow stabilizer (15a, 15b) is located in the fluid conduit upstream of the ultrasonic transducer (17a, 17b), wherein the deflecting element is formed substantially as a dome, with an apex of the dome facing in a direction away from the ultrasonic transducer; and wherein in the flow stabilizer, a fluid drain passage is provided at the apex of the dome and a plurality of fluid drain passages (38, 39a, 39b, 39c, 39d) are provided extending substantially radially around the base of the dome. a fluid conduit with an inlet and an outlet (5, 6), the fluid conduit bound by an inner periphery; and a first and a second ultrasonic transducer (17a, 17b) for measuring a fluid flow in the fluid conduit; wherein the first and second ultrasonic transducers (17a, 17b) are arranged in facing alignment; and wherein the first and second ultrasonic transducers (17a, 17b) are arranged within the fluid conduit spaced from said inner periphery, and wherein each of the first and second ultrasonic transducers (17a, 17b) are supported by an associated support mounting (16a, 16b), and wherein a plurality of fluid apertures (21a, 21b, 21c, 21d) are provided around each ultrasonic transducer (17a, 17b) wherein each ultrasonic transducer (17a, 17b) is provided with a flow stabiliser (15a, 15b), each flow stabilizer including a fluid deflecting element for deflecting, in use, fluid flowing in the fluid conduit around the respective ultrasonic transducer when the flow stabilizer (15a, 15b) is located in the fluid conduit upstream of the ultrasonic transducer (17a, 17b), wherein the deflecting element is formed substantially as a dome, with an apex of the dome facing in a direction away from the ultrasonic transducer; and wherein in the flow stabilizer, a fluid drain passage is provided at the apex of the dome and a plurality of fluid drain passages (38, 39a, 39b, 39c, 39d) are provided extending substantially radially around the base of the dome.
An off-shore wind turbine comprising a tower and a foundation, a wind rotor, a nacelle structure mounted on said tower housing wind turbine components and, an air-treatment system at the level of the base of the tower providing treated air to the nacelle structure, through a duct inside the tower, for thermal conditioning purposes characterized in that said duct comprises an insulating structure that reduces the thermal losses by convection of said treated air when it circulates through the duct from the base-level to the nacelle structure, the insulating structure comprising insulating material of a greater thermal conductivity than the air and a plurality of voids arranged between insulating material so that air flow between said voids is prevented, and characterized in that the Input to said air-treatment system Is ambient air and the output of said air-treatment system is treated air having a reduced level of moisture and salinity and a temperature set as a function of the temperature of the air inside the tower, according to the thermal conditioning needs of the nacelle structure.
A pharmaceutical formulation for lyophilization comprising carmustine dissolved in solvent consisting of t-butanol and about 5% (v/v) to about 15% (v/v) dehydrated alcohol selected from ethanol or isopropanol.
A method for extending an operational time of a mobile station, MS, (106, 202), comprising: measuring a residual battery capacity of the MS, while the MS has one or more active transport connections; determining, at the MS, a most constrained maximum latency requirement of the one or more active transport connections; and activating a sleep mode operation at the MS if the residual battery capacity is below a predefined threshold value characterized by, wherein a length S of a sleep window of the sleep mode is selected such that S allows the MS to meet the most constrained maximum latency requirement of the one or more active transport connections, and wherein the length S of the sleep window of the sleep mode and a length L of a listening window of the sleep mode are also selected to achieve a power savings metric determined based on a ratio of L to the sum of S and L. measuring a residual battery capacity of the MS, while the MS has one or more active transport connections; determining, at the MS, a most constrained maximum latency requirement of the one or more active transport connections; and activating a sleep mode operation at the MS if the residual battery capacity is below a predefined threshold value characterized by, wherein a length S of a sleep window of the sleep mode is selected such that S allows the MS to meet the most constrained maximum latency requirement of the one or more active transport connections, and wherein the length S of the sleep window of the sleep mode and a length L of a listening window of the sleep mode are also selected to achieve a power savings metric determined based on a ratio of L to the sum of S and L.
A process for selectively reducing the level of perfluoroalkanoic acids and salts thereof in the presence of 1-iodo-1H,1H,2H,2H-perfluoroalkane comprising heating a 1-iodo-1H,1H,2H,2H-perfluoroalkane, or mixtures thereof, containing said perfluoroalkanoic acids or salts thereof to a temperature of at least 175°C in the presence of at least one organic additive, wherein the organic additive is a compound having a molecular weight from 28 to 1000, selected from the group consisting of glycols, alkyl alcohols, alkyl ethers, amides, tertiary amines, salts thereof, saturated and unsaturated hydrocarbons, and is present at a level of 0.1% to 20% by weight of the 1-iodo-1H,1H,2H,2H-perfluoroalkane.
An applicator including; ▪ an inlet for receiving a fluid to be dispensed; ▪ an outlet for dispensing the fluid to be dispensed; and ▪ flow control means for controlling flow from the inlet to the outlet, the flow control means including a first member and a second member, the arrangement being such that relative movement of the first member towards the second member causes fluid to flow from the outlet; characterised in that the applicator further includes: ▪ a hinged linkage having a first end rotatably engaged with the first member, a second end rotatably engaged with the second member, and a hinge intermediate the first and second ends,, the linkage moveable between a collapsed position wherein the hinge is on a first side of a notional axis extending between first and second ends,, and an over-centre locked position wherein the hinge is on an opposite side of the notional axis between the first and second ends, and the hinged linkage prevents relative movement of the first member towards the second member; and ▪ linkage unlocking means operable to move the hinge from the over-centre locked position to the first side of the notional axis between the first and second ends,, so that the hinged linkage can be moved to the collapsed position as the first and second members, are moved together. ▪ an inlet for receiving a fluid to be dispensed; ▪ an outlet for dispensing the fluid to be dispensed; and ▪ flow control means for controlling flow from the inlet to the outlet, the flow control means including a first member and a second member, the arrangement being such that relative movement of the first member towards the second member causes fluid to flow from the outlet; ▪ a hinged linkage having a first end rotatably engaged with the first member, a second end rotatably engaged with the second member, and a hinge intermediate the first and second ends,, the linkage moveable between a collapsed position wherein the hinge is on a first side of a notional axis extending between first and second ends,, and an over-centre locked position wherein the hinge is on an opposite side of the notional axis between the first and second ends, and the hinged linkage prevents relative movement of the first member towards the second member; and ▪ linkage unlocking means operable to move the hinge from the over-centre locked position to the first side of the notional axis between the first and second ends,, so that the hinged linkage can be moved to the collapsed position as the first and second members, are moved together.
An in vitro method of detecting apoptosis in a mammalian cell comprising: (a) contacting the cell with an antibody that binds to a protein fragment generated during apoptosis, wherein the antibody binds to a protein fragment of AP2-α (SEQ ID NO: 1); (b) determining the amount of the antibody which binds to the protein fragment generated during apoptosis; and (c) comparing the amount of antibody bound in step (b) with the amount of antibody which binds to the protein fragment in a mammalian cell free of apoptosis, wherein if the amount in step (b) is greater than the amount in the cell free of apoptosis, then apoptosis is detected; wherein apoptosis in the cell is initiated through Death Receptor 4 (SEQ ID NO: 5), Death Receptor 5 (SEQ ID NO: 6) or Fas (SEQ ID NO: 8). (a) contacting the cell with an antibody that binds to a protein fragment generated during apoptosis, wherein the antibody binds to a protein fragment of AP2-α (SEQ ID NO: 1); (b) determining the amount of the antibody which binds to the protein fragment generated during apoptosis; and (c) comparing the amount of antibody bound in step (b) with the amount of antibody which binds to the protein fragment in a mammalian cell free of apoptosis, wherein if the amount in step (b) is greater than the amount in the cell free of apoptosis, then apoptosis is detected;
A solid ion conductor, wherein said conductor has a garnet-type crystal structure and has a stoichiometric composition formally derived by aliovalent substitution from Li 5 La 3 M 2 O 12 where M is Nb or Ta.
A multi-piece spoked steering wheel assembly, comprising: a spoked hub adapter configured for attachment to a central steering column, and comprising a center plate and a plurality of spaced apart hub spokes, each hub spoke having a proximal end integrally formed with said center plate and a distal end extending outwardly from said center plate; an exchangeable spoked steering wheel comprising an outer rim and a plurality of spaced interior wheel spokes, each wheel spoke having a proximal end integrally formed with said outer rim and a distal end extending inwardly from said outer rim and in a direction of said spoked hub adapter, such that distal ends of said hub spokes align with distal ends of said wheel spokes, and wherein said plurality of wheel spokes comprises first and second opposing wheel spokes located in respective 3 o'clock and 9 o'clock positions relative to said outer rim, and wherein each of said first and second wheel spokes comprises an inwardly-pointed controller surround configured to border a portion of a game controller located adjacent the steering column; and a plurality of fasteners removably attaching together the aligned distal ends of said hub spokes and said wheel spokes, thereby interconnecting said spoked hub adapter and said steering wheel in said multi-piece spoked steering wheel assembly. a spoked hub adapter configured for attachment to a central steering column, and comprising a center plate and a plurality of spaced apart hub spokes, each hub spoke having a proximal end integrally formed with said center plate and a distal end extending outwardly from said center plate; an exchangeable spoked steering wheel comprising an outer rim and a plurality of spaced interior wheel spokes, each wheel spoke having a proximal end integrally formed with said outer rim and a distal end extending inwardly from said outer rim and in a direction of said spoked hub adapter, such that distal ends of said hub spokes align with distal ends of said wheel spokes, and wherein said plurality of wheel spokes comprises first and second opposing wheel spokes located in respective 3 o'clock and 9 o'clock positions relative to said outer rim, and wherein each of said first and second wheel spokes comprises an inwardly-pointed controller surround configured to border a portion of a game controller located adjacent the steering column; and a plurality of fasteners removably attaching together the aligned distal ends of said hub spokes and said wheel spokes, thereby interconnecting said spoked hub adapter and said steering wheel in said multi-piece spoked steering wheel assembly.
A gas feed method for a gas engine or dual-fuel engine in which combustion gas is combusted with combustion air, wherein a gas valve for feeding combustion gas into the combustion air is arranged upstream of the gas engine or dual-fuel engine, wherein the gas engine or dual-fuel engine is acted upon by a variable charge air pressure, wherein the combustion gas is fed in a non-regulated manner to the gas valve independently of the operating state of the gas engine or dual-fuel engine and in the process the gas metering takes place solely by precise control of the gas valve, namely during the operation of the gas motor or dual-fuel motor, the pressure upstream and downstream of the gas valve and the temperature of the fed combustion gas are measured, the engine operating point is determined and from that the opening duration and/or the freed opening cross-sectional area of the gas valve is/are controlled, wherein the gas valve is arranged directly upstream of the intake region of the gas engine or dual-fuel engine.
Fastening arrangement comprising a fastening element for the elastic connection of an add-on part to a support part, wherein the fastening element has a head section that transitions into an element shank, wherein an elastomer profile part with a retaining groove which is open radially to the outside, and into which a retaining foot of the add-on part can engage, is arranged on the underside of the head section, wherein the retaining groove is designed with a groove wall on the head side and a groove wall on the shank side, wherein the elastomer profile part is constructed at least in two parts from an elastomer body arranged on the head section of the fastening element and from a disk element which has at least the shank-side groove wall of the retaining groove, characterized in that for the purpose of forming the axial guide of the disk element, at least one axial rib projects axially from the inner perimeter of the disk element, and is guided in an axial groove located in the groove bottom of the retaining groove so as to be axially movable but rotationally fixed. wherein the fastening element has a head section that transitions into an element shank, wherein an elastomer profile part with a retaining groove which is open radially to the outside, and into which a retaining foot of the add-on part can engage, is arranged on the underside of the head section, wherein the retaining groove is designed with a groove wall on the head side and a groove wall on the shank side, wherein the elastomer profile part is constructed at least in two parts from an elastomer body arranged on the head section of the fastening element and from a disk element which has at least the shank-side groove wall of the retaining groove, characterized in that for the purpose of forming the axial guide of the disk element, at least one axial rib projects axially from the inner perimeter of the disk element, and is guided in an axial groove located in the groove bottom of the retaining groove so as to be axially movable but rotationally fixed.
A device for delivering medicament into skin of a patient, the device comprising: a filling member comprising: a first conduit; and a second conduit that fluidly communicates with the first conduit to fill the filling member with medicament; wherein the filling member provides two-way medicament flow that: enters a reservoir via the first and second conduits (112, 114); exits the reservoir into the first conduit; and exits the first conduit to a pump; characterized in that the first conduit engages a reservoir pathway connected to the reservoir and a portion of a base connected to the pump, a centerline of the reservoir pathway and a centerline of the portion of the base are substantially in-line with a centerline of the first conduit. a filling member comprising: a first conduit; and a second conduit that fluidly communicates with the first conduit to fill the filling member with medicament; a first conduit; and a second conduit that fluidly communicates with the first conduit to fill the filling member with medicament; wherein the filling member provides two-way medicament flow that: enters a reservoir via the first and second conduits (112, 114); exits the reservoir into the first conduit; and exits the first conduit to a pump; characterized in that the first conduit engages a reservoir pathway connected to the reservoir and a portion of a base connected to the pump, a centerline of the reservoir pathway and a centerline of the portion of the base are substantially in-line with a centerline of the first conduit. enters a reservoir via the first and second conduits (112, 114); exits the reservoir into the first conduit; and exits the first conduit to a pump; characterized in that the first conduit engages a reservoir pathway connected to the reservoir and a portion of a base connected to the pump, a centerline of the reservoir pathway and a centerline of the portion of the base are substantially in-line with a centerline of the first conduit.
A method for operating a wind turbine, the wind turbine comprising a rotor having a set of wind turbine blades, said rotor being mounted on a tower, the method comprising the steps of: - providing a curve defining optimal pitch angle as a function of tip speed ratio for the wind turbine blades or as a function of wind speed, the optimal pitch angle being the pitch angle which, under given wind conditions, provides the highest possible power output or power coefficient, C P, for the wind turbine, - modifying only a part of said optimal pitch angle curve by applying a safety buffer, thereby obtaining a safety modified pitch angle curve, the safety buffer being applied in order to prevent blade stall, and/or that one or more components of the wind turbine are overloaded, - operating the wind turbine in accordance with the safety modified pitch angle curve, - measuring one or more parameters providing information regarding wind conditions and/or loads on one or more components of the wind turbine, during operation of the wind turbine, - adjusting the safety buffer, based on said measurements, thereby obtaining an adjusted pitch angle curve, and - operating the wind turbine in accordance with the adjusted pitch angle curve. - providing a curve defining optimal pitch angle as a function of tip speed ratio for the wind turbine blades or as a function of wind speed, the optimal pitch angle being the pitch angle which, under given wind conditions, provides the highest possible power output or power coefficient, C P, for the wind turbine, - modifying only a part of said optimal pitch angle curve by applying a safety buffer, thereby obtaining a safety modified pitch angle curve, the safety buffer being applied in order to prevent blade stall, and/or that one or more components of the wind turbine are overloaded, - operating the wind turbine in accordance with the safety modified pitch angle curve, - measuring one or more parameters providing information regarding wind conditions and/or loads on one or more components of the wind turbine, during operation of the wind turbine, - adjusting the safety buffer, based on said measurements, thereby obtaining an adjusted pitch angle curve, and - operating the wind turbine in accordance with the adjusted pitch angle curve.
An agricultural harvester having a chopper system, comprising: an inline shaft system, a shift collar configured to engage splines (84, 86) of the chopper system; and an actuator shiftingly coupled to said shift collar; characterized in that the agricultural harvester further comprises a controller operatively coupled to said actuator, said controller being configured to carry out the steps of: detecting a failure to properly engage said shift collar with a splined component; temporarily rotating the inline shaft system; and engaging said shift collar with said splined component. an inline shaft system, a shift collar configured to engage splines (84, 86) of the chopper system; and an actuator shiftingly coupled to said shift collar; characterized in that the agricultural harvester further comprises a controller operatively coupled to said actuator, said controller being configured to carry out the steps of: detecting a failure to properly engage said shift collar with a splined component; temporarily rotating the inline shaft system; and engaging said shift collar with said splined component. detecting a failure to properly engage said shift collar with a splined component; temporarily rotating the inline shaft system; and engaging said shift collar with said splined component.