Compounds of formula 1 wherein A is phenyl or a five- or six-membered, aromatic heteroring, wherein one, two or three elements are replaced by an element selected independent from each other from the group consisting of N, (O -)-N +, O and S; R 1a is wherein X 1 indicates the bond which is connected to the core molecule as defined in formula 1; R 1a.1 is C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, H 2 N-, C 1-4 -alkyl-NH-, C 3-6 -cycloalkyl-NH-, (C 1-4 -alkyl) 2 N-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N-, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl-C 1-4 -alkyl-, C 1-4 -alkyl-O-NH-, (C 1-4 -alkyl-O)(C 1-4 -alkyl)N-; R 1a.2 is H, NC-, O 2 N-, C 1-4 -alkyl-SO 2 -, aryl-SO 2 -, (aromatic heteroring)-SO 2 -, C 1-4 -alkyl-O- C-, C 1-4 -alkyl- C-, C 3-6 -cycloalkyl- C-, H 2 N- C-, C 1-4 -alkyl-NH- C-, C 3-6 -cycloalkyl-NH- C-, (C 1-4 -alkyl) 2 N- C-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N- C-, azetidinyl- C-, pyrrolidinyl- C-, piperidinyl- C-, morpholinyl- C-, piperazinyl- C-, piperazinyl-C 1-4 -alkyl- C-, C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, aryl, heteroaryl; R 1b is H, C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl- or halogen; or R 1a and R 1b are together C 2-4 -alkylene forming a carbocyclic heteroring; R 2 is C 1-6 -alkyl or a residue selected from the group consisting of C 3-6 -cycloalkyl-, wherein one element of the ring is optionally replaced by O; phenyl-C 1-4 -alkyl-, (aromatic heteroring)-C 1-4 -alkyl- and a five- or six-membered, aromatic heteroring, wherein one, two or three elements are replaced by an element selected independent from each other from the group consisting of N, O and S; each element of one of the rings optionally substituted with one or two groups selected from C 1-4 -alkyl-, C 3-6 -cycloalkyl-, halogen, C 1-4 -haloalkyl-, C 1-4 -alkyl-O-, C 1-4 -alkyl-SO 2 - or NC-; R 3 is H or C 1-4 -alkyl-; R 4 is phenyl, a five- or six-membered, aromatic heteroring containing one, two or three atoms selected from N, O and S; each optionally substituted with one or two residues selected independently from each other from the group consisting of C 1-4 -alkyl-, C 3-6 -cycloalkyl-, halogen or C 1-4 -haloalkyl-; R 5 is H, C 1-4 -alkyl-, C 1-4 -haloalkyl-, C 3-6 -cycloalkyl-, R 6 is H or C 1-4 -alkyl-; R 7 is H or C 1-4 -alkyl-; or R 6 and R 7 are forming together a C 2-5 -alkylene, wherein one element of the formed ring is optionally replaced by O; or a pharmaceutically acceptable salt thereof. A is phenyl or a five- or six-membered, aromatic heteroring, wherein one, two or three elements are replaced by an element selected independent from each other from the group consisting of N, (O -)-N +, O and S; R 1a is wherein X 1 indicates the bond which is connected to the core molecule as defined in formula 1; R 1a.1 is C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, H 2 N-, C 1-4 -alkyl-NH-, C 3-6 -cycloalkyl-NH-, (C 1-4 -alkyl) 2 N-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N-, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl-C 1-4 -alkyl-, C 1-4 -alkyl-O-NH-, (C 1-4 -alkyl-O)(C 1-4 -alkyl)N-; R 1a.2 is H, NC-, O 2 N-, C 1-4 -alkyl-SO 2 -, aryl-SO 2 -, (aromatic heteroring)-SO 2 -, C 1-4 -alkyl-O- C-, C 1-4 -alkyl- C-, C 3-6 -cycloalkyl- C-, H 2 N- C-, C 1-4 -alkyl-NH- C-, C 3-6 -cycloalkyl-NH- C-, (C 1-4 -alkyl) 2 N- C-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N- C-, azetidinyl- C-, pyrrolidinyl- C-, piperidinyl- C-, morpholinyl- C-, piperazinyl- C-, piperazinyl-C 1-4 -alkyl- C-, C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, aryl, heteroaryl; R 1a.1 is C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, H 2 N-, C 1-4 -alkyl-NH-, C 3-6 -cycloalkyl-NH-, (C 1-4 -alkyl) 2 N-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N-, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl-C 1-4 -alkyl-, C 1-4 -alkyl-O-NH-, (C 1-4 -alkyl-O)(C 1-4 -alkyl)N-; R 1a.2 is H, NC-, O 2 N-, C 1-4 -alkyl-SO 2 -, aryl-SO 2 -, (aromatic heteroring)-SO 2 -, C 1-4 -alkyl-O- C-, C 1-4 -alkyl- C-, C 3-6 -cycloalkyl- C-, H 2 N- C-, C 1-4 -alkyl-NH- C-, C 3-6 -cycloalkyl-NH- C-, (C 1-4 -alkyl) 2 N- C-, (C 3-6 -cycloalkyl)(C 1-4 -alkyl)N- C-, azetidinyl- C-, pyrrolidinyl- C-, piperidinyl- C-, morpholinyl- C-, piperazinyl- C-, piperazinyl-C 1-4 -alkyl- C-, C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl-, aryl, heteroaryl; R 1b is H, C 1-4 -alkyl-, C 3-6 -cycloalkyl-, C 1-4 -haloalkyl- or halogen; or R 1a and R 1b are together C 2-4 -alkylene forming a carbocyclic heteroring; R 2 is C 1-6 -alkyl or a residue selected from the group consisting of C 3-6 -cycloalkyl-, wherein one element of the ring is optionally replaced by O; phenyl-C 1-4 -alkyl-, (aromatic heteroring)-C 1-4 -alkyl- and a five- or six-membered, aromatic heteroring, wherein one, two or three elements are replaced by an element selected independent from each other from the group consisting of N, O and S; each element of one of the rings optionally substituted with one or two groups selected from C 1-4 -alkyl-, C 3-6 -cycloalkyl-, halogen, C 1-4 -haloalkyl-, C 1-4 -alkyl-O-, C 1-4 -alkyl-SO 2 - or NC-; R 3 is H or C 1-4 -alkyl-; R 4 is phenyl, a five- or six-membered, aromatic heteroring containing one, two or three atoms selected from N, O and S; each optionally substituted with one or two residues selected independently from each other from the group consisting of C 1-4 -alkyl-, C 3-6 -cycloalkyl-, halogen or C 1-4 -haloalkyl-; R 5 is H, C 1-4 -alkyl-, C 1-4 -haloalkyl-, C 3-6 -cycloalkyl-, R 6 is H or C 1-4 -alkyl-; R 7 is H or C 1-4 -alkyl-; or R 6 and R 7 are forming together a C 2-5 -alkylene, wherein one element of the formed ring is optionally replaced by O;