mhurhangee/ep-ind-claims huggingface dataset:
Compound of formula I for use in the treatment of a Hepatitis C Virus infection wherein: R 1 is H, halo, C 1 -C 6 haloalkyl, lower haloalkyl C 1 -C 6 alkyl, trifluoromethyl sulfonyl, C 1 -C 6 alkyl, alkoxy, nitro, carboxyl, C 1 -C 6 alkyl sulfonamido, trifluoromethyl sulfinyl, cycloalkyl, SF 5, or -NHNH 2; R 2 is H, halo, cyano, nitro, trifluoromethyl sulfonyl, C 1 -C 6 halo alkyl, phenyl ethynyl, C 1 -C 6 alkyl sulfonyl, C 1 -C 6 alkyl amino sulfonyl, C 1 -C 6 alkyl amido, amino sulfonyl, sulfonamido, benzyl oxy, cycloalkyl, heterocycloalkyl sulfonyl, aryl carbonyl, C 1 -C 6 alkyl urea, C 1 -C 6 alkyl ester, phenyl amido, heterocycloalkyl carbonyl, C 1 -C 6 alkyl sulfonyl phenyl amido, C 1 -C 6 alkyl cyano, cyano C 1 -C 6 alkyl, or tetrazolyl C 1 -C 6 alkyl; R 3 is H, halo, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 haloalkyl, cyano, C 1 -C 6 haloalkyl oxy, cyano cycloalkyl, C 1 -C 6 haloalkyl C 1 -C 6 alkyl, SF 5, or trifluoromethyl sulfanyl; or R 2 and R 3 together form an aryl ring system; R 4 is H, C 1 -C 6 alkyl, cyano C 1 -C 6 alkyl, or phenyl C 1 -C 6 alkyl; R 5 is absent, H, C 1 -C 6 alkyl, or cycloalkyl; R 6 is H or halo; R 7 is absent, H, C 1 -C 6 alkyl carbonyl, or C 1 -C 6 haloalkyl phenyl sulfonyl; with the proviso that when R 5 is absent, R 7 is not absent; and with the proviso that when R 7 is absent, R 5 is not absent; or a pharmaceutically acceptable salt thereof, wherein carboxyl denotes a group of formula -C (=O)R 2 wherein each R is independently H or C 1 -C 6 alkyl; wherein amido denotes a group of formla -C (=O)NR'R" or -NR'C(=O)R" wherein R' and R" are independently H, alkyl, alkoxy, cycloalkyl, heterocyclo-alkyl, aryl or heteroaryl; wherein amino denotes a group of forumal -NR'R" wherein R' and R" are independently H, alkyl, alkoxy, cycloakyl, heterocycloalkyl, aryl or heteroaryl and wherein R' and R" optionally form together with the mitrogen to which they are attached a heterocycloalkyl. R 1 is H, halo, C 1 -C 6 haloalkyl, lower haloalkyl C 1 -C 6 alkyl, trifluoromethyl sulfonyl, C 1 -C 6 alkyl, alkoxy, nitro, carboxyl, C 1 -C 6 alkyl sulfonamido, trifluoromethyl sulfinyl, cycloalkyl, SF 5, or -NHNH 2; R 2 is H, halo, cyano, nitro, trifluoromethyl sulfonyl, C 1 -C 6 halo alkyl, phenyl ethynyl, C 1 -C 6 alkyl sulfonyl, C 1 -C 6 alkyl amino sulfonyl, C 1 -C 6 alkyl amido, amino sulfonyl, sulfonamido, benzyl oxy, cycloalkyl, heterocycloalkyl sulfonyl, aryl carbonyl, C 1 -C 6 alkyl urea, C 1 -C 6 alkyl ester, phenyl amido, heterocycloalkyl carbonyl, C 1 -C 6 alkyl sulfonyl phenyl amido, C 1 -C 6 alkyl cyano, cyano C 1 -C 6 alkyl, or tetrazolyl C 1 -C 6 alkyl; R 3 is H, halo, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 haloalkyl, cyano, C 1 -C 6 haloalkyl oxy, cyano cycloalkyl, C 1 -C 6 haloalkyl C 1 -C 6 alkyl, SF 5, or trifluoromethyl sulfanyl; or R 2 and R 3 together form an aryl ring system; R 4 is H, C 1 -C 6 alkyl, cyano C 1 -C 6 alkyl, or phenyl C 1 -C 6 alkyl; R 5 is absent, H, C 1 -C 6 alkyl, or cycloalkyl; R 6 is H or halo; R 7 is absent, H, C 1 -C 6 alkyl carbonyl, or C 1 -C 6 haloalkyl phenyl sulfonyl;
An isolated or purified antibody or fragment thereof, comprising a variable light chain comprising the sequence of complementarity determining region L1 of sequence KASQDVTAAVA (SEQ ID NO:4); the sequence of CDR L2 of sequence SASYRYT (SEQ ID NO:8); and the sequence of CDR L3 of sequence QQYYNTPLT (SEQ ID NO: 12), and a variable heavy chain comprising the sequence of complementarity determining region H1 of sequence EHIIN (SEQ ID NO: 16); the sequence of CDR H2 of sequence LINPNSGGTNYNQKFKD (SEQ ID NO:20); and the sequence of CDR H3 of sequence LRYDAAY (SEQ ID NO:24), wherein the isolated or purified antibody or fragment thereof specifically recognizes and binds to ricin toxin lectin-B protein. a variable light chain comprising the sequence of complementarity determining region L1 of sequence KASQDVTAAVA (SEQ ID NO:4); the sequence of CDR L2 of sequence SASYRYT (SEQ ID NO:8); and the sequence of CDR L3 of sequence QQYYNTPLT (SEQ ID NO: 12), and the sequence of complementarity determining region L1 of sequence KASQDVTAAVA (SEQ ID NO:4); the sequence of CDR L2 of sequence SASYRYT (SEQ ID NO:8); and the sequence of CDR L3 of sequence QQYYNTPLT (SEQ ID NO: 12), and a variable heavy chain comprising the sequence of complementarity determining region H1 of sequence EHIIN (SEQ ID NO: 16); the sequence of CDR H2 of sequence LINPNSGGTNYNQKFKD (SEQ ID NO:20); and the sequence of CDR H3 of sequence LRYDAAY (SEQ ID NO:24), the sequence of complementarity determining region H1 of sequence EHIIN (SEQ ID NO: 16); the sequence of CDR H2 of sequence LINPNSGGTNYNQKFKD (SEQ ID NO:20); and the sequence of CDR H3 of sequence LRYDAAY (SEQ ID NO:24),
A hearing protective earplug insertable into a human ear canal having sidewalls and a typical curved portion, comprsing - a soft main resilient body having a main body element having a front end, - an elongated stem having two ends, one end attached to the main body element, the stem extending outward from the main body element and away from the front end, the other end of the stem forming a handle portion of the stem, the stem being sufficiently stiff as to allow manipulation of the main body element during insertion into the ear canal, and - the stem member having a portion with a crooked or wavy configuration as it extends outward from the main body to the handle portion of the stem and so that during insertion of the front end of the main body element into the ear canal, rotation of the stem member with the handle portion will fit the stem member around the typical curved portion in the human ear canal so as to seat the main body element to acoustically block the ear canal while at the same time spacing the stem member within the typical curved portion of the ear canal to minimize contact with the sidewalls of the ear canal, characterized in that the distance between the one end of the stem and the handle portion of the stem has a range between 6 mm to 25 mm, and wherein the crooked or wavy portion of stem member has at least three curved stem portions and/or at least three straight angularly displaced adjacent portions. - a soft main resilient body having a main body element having a front end, - an elongated stem having two ends, one end attached to the main body element, the stem extending outward from the main body element and away from the front end, the other end of the stem forming a handle portion of the stem, the stem being sufficiently stiff as to allow manipulation of the main body element during insertion into the ear canal, and - the stem member having a portion with a crooked or wavy configuration as it extends outward from the main body to the handle portion of the stem and so that during insertion of the front end of the main body element into the ear canal, rotation of the stem member with the handle portion will fit the stem member around the typical curved portion in the human ear canal so as to seat the main body element to acoustically block the ear canal while at the same time spacing the stem member within the typical curved portion of the ear canal to minimize contact with the sidewalls of the ear canal, characterized in that the distance between the one end of the stem and the handle portion of the stem has a range between 6 mm to 25 mm, and wherein the crooked or wavy portion of stem member has at least three curved stem portions and/or at least three straight angularly displaced adjacent portions.
A wireless earphone system comprising a first earphone and a second earphone and an audio rendering device, wherein the first earphone comprises a first earphone transceiver of a first type, and a second earphone transceiver of a second type, the second earphone comprises a third earphone transceiver of the first type, wherein a first wireless link can be established between the first earphone transceiver and the third earphone transceiver, wherein a second wireless link can be established between the second earphone transceiver and an audio rendering transceiver of the second type of the audio rendering device, wherein the first earphone is adapted to send a first link status signal via the second wireless link to the audio rendering device, the first link status signal indicating whether the first link is established or broken, wherein the audio rendering device has a rendering transceiver of the second type, CHARACTERIZED in that the audio rendering device comprises a localisation module to determine the localisation of the audio rendering device and a memory module to store a localisation data set representing the location of the audio rendering device, and wherein the localisation module is adapted to store a localisation data set, when the audio rendering device receives the first link status signal from the first earphone.
Pharmaceutical composition comprising drug loaded nano-resin particles having a particle size distribution characterized in that the D 90 value is between 200 nanometers to 900 nanometers and D 10 value is not less than 50 nanometers for use in medicine.
A method of stabilizing the particle size of a pharmaceutical ingredient in suspension comprising the steps of: a) Reducing the particle size of the pharmaceutical ingredient in the suspension under high pressure conditions by using a high pressure homogenization apparatus, wherein the high pressure conditions refer to pressures in the range of from 500 to 3500 bar; and b) Isolating the particles from the suspension in the form of a powder, characterized in that during the isolation step at least a part of the suspension is recycled to the high pressure homogenization apparatus under mild pressure conditions, which refer to any pressure conditions below the previously applied high pressure conditions. a) Reducing the particle size of the pharmaceutical ingredient in the suspension under high pressure conditions by using a high pressure homogenization apparatus, wherein the high pressure conditions refer to pressures in the range of from 500 to 3500 bar; and b) Isolating the particles from the suspension in the form of a powder, characterized in that during the isolation step at least a part of the suspension is recycled to the high pressure homogenization apparatus under mild pressure conditions, which refer to any pressure conditions below the previously applied high pressure conditions.
A method of fabricating an integrated light emitting diode micro-display, in particular an integrated full-colour LED micro-display, comprising: providing a colour converter capable of changing the wavelength of light, the colour converter including: a red/green/blue colour conversion layer; a transparent substrate; a transparent layer; and a reflective mask; providing an array of micro-LEDs connected to the colour converter and which is capable of forming electrical connections and pumping ultraviolet light into the colour converter; and providing a backplane control in the form of an electronic drive layer; wherein the micro-LED array generates pumped UV light at a shorter wavelength than emitted light from the colour converter thereby producing light at a longer wavelength; wherein the integrated LED micro-display has a matrix of red colour conversion cells, green colour conversion cells, and blue colour conversion cells with the cells containing colour conversion material. a red/green/blue colour conversion layer; a transparent substrate; a transparent layer; and a reflective mask; providing an array of micro-LEDs connected to the colour converter and which is capable of forming electrical connections and pumping ultraviolet light into the colour converter; and providing a backplane control in the form of an electronic drive layer; wherein the micro-LED array generates pumped UV light at a shorter wavelength than emitted light from the colour converter thereby producing light at a longer wavelength; wherein the integrated LED micro-display has a matrix of red colour conversion cells, green colour conversion cells, and blue colour conversion cells with the cells containing colour conversion material.
An apparatus comprising: a fiber layer, wherein the fiber layer is one of a number of fiber layers that are laid up to form a reinforcement layup, wherein the fiber layer comprises: a plurality of fiber bundles having a number of spaces between the plurality of fiber bundles; a number of filler portions comprised of discontinuous filaments that substantially fill the number of spaces between the plurality of fiber bundles; a resin infused within the number of fiber layers, characterized in that it comprises further: a number of interlayer filler portions (126, 232) comprised of the discontinuous filaments and located between the number of fiber layers; and a number of outer filler portions (130, 234) comprised of the discontinuous filaments and located around the number of fiber layers. a plurality of fiber bundles having a number of spaces between the plurality of fiber bundles; a number of filler portions comprised of discontinuous filaments that substantially fill the number of spaces between the plurality of fiber bundles; a resin infused within the number of fiber layers, characterized in that it comprises further: a number of interlayer filler portions (126, 232) comprised of the discontinuous filaments and located between the number of fiber layers; and a number of outer filler portions (130, 234) comprised of the discontinuous filaments and located around the number of fiber layers. a number of interlayer filler portions (126, 232) comprised of the discontinuous filaments and located between the number of fiber layers; and a number of outer filler portions (130, 234) comprised of the discontinuous filaments and located around the number of fiber layers.
A kit of parts for securing railings in doors and windows on the construction site, the kit comprising: railings having a rectangular cross section, and a securing device ( 102, 104, 106, 108, 110) comprising a rectangular opening, corresponding to the cross section of the railings, for securing the railings between a pair of first outer side walls ( 104 and 106) and a pair of second outer side walls where each of said walls constitute a side of said rectangular opening; wherein the first pair of outer side walls ( 104 and 106) include one or more protrusions at both the sides walls ( 104 and 106); the kit of parts being characterised by further comprising a circular wall attachment having a circular base for being attached to a wall surface, wherein the circular wall attachment holds one of said railings in place on the wall surface when in use; wherein the circular base includes a plurality of sectional grooves for receiving and holding one end of said one of said railings in place in the circular base. a securing device ( 102, 104, 106, 108, 110) comprising a rectangular opening, corresponding to the cross section of the railings, for securing the railings between a pair of first outer side walls ( 104 and 106) and a pair of second outer side walls where each of said walls constitute a side of said rectangular opening; wherein the first pair of outer side walls ( 104 and 106) include one or more protrusions at both the sides walls ( 104 and 106); the kit of parts being characterised by further comprising a circular wall attachment having a circular base for being attached to a wall surface, wherein the circular wall attachment holds one of said railings in place on the wall surface when in use; wherein the circular base includes a plurality of sectional grooves for receiving and holding one end of said one of said railings in place in the circular base.
An apparatus comprising at least one processor, and at least one memory including a computer program code, wherein the at least one memory and the computer program code are configured, with the at least one processor, to cause the apparatus to: receive a modulated radio signal transmitting coded information bits; perform demodulating on the modulated radio signal, wherein demodulating comprises performing orthogonal time frequency space demodulation; perform equalization on the demodulated radio signal to obtain equalized symbols; obtain log-likelihood ratios for the coded information bits from the equalized symbols using a trained machine learning model; reconstruct the coded information bits; and wherein the machine learning model is trained jointly with transmitter windowing optimizing and receiver windowing optimizing, wherein the transmitter window optimizing and receiver window optimizing comprises optimizing transmitter windowing parameter and receiver windowing parameter. receive a modulated radio signal transmitting coded information bits; perform demodulating on the modulated radio signal, wherein demodulating comprises performing orthogonal time frequency space demodulation; perform equalization on the demodulated radio signal to obtain equalized symbols; obtain log-likelihood ratios for the coded information bits from the equalized symbols using a trained machine learning model; reconstruct the coded information bits; and wherein the machine learning model is trained jointly with transmitter windowing optimizing and receiver windowing optimizing, wherein the transmitter window optimizing and receiver window optimizing comprises optimizing transmitter windowing parameter and receiver windowing parameter.
Air duct arrangement for the aeration and exhaust ventilation of a room or parts thereof with a hose or a tube and a housing with a connection sleeve for the arrangement of the hose or of the tube fluidically connected with the volume interior space of the housing as well as a size variable flow passage, configured on the room side, with an integrated filter holder, characterized in that the hose or the tube is placed in a secured manner in the connection sleeve, wherein the hose or the tube is designed corrugated and a locking pin designed as a bracket is provided for securing the hose or the tube inside the connection sleeve, locking pin that projects through a trough of the corrugated designed hose or of the tube on the one hand and through recesses configured in the connection sleeve on the other hand.
Connection device for connecting an end of a fluid line to an assembly, in particular a motor vehicle assembly, which device has - a stub with a through opening for receiving the fluid line at one end of the through opening, - and a flange with a first opening for receiving the stub and a second opening for fastening to the assembly, wherein - the stub is introduced into the first opening and is connected to the flange in a material-to-material manner by means of a soldered connection, and - the flange has a plug-in region and an inner bore which faces away from the plug-in region, characterized - in that, on that surface of the plug-in region which faces the stub in the plug-in direction, the flange has a depression which runs in the circumferential direction in the region of the integrally joined connection, which depression runs radially around the first opening, and in that the solder for producing the soldered connection is applied on the inner bore which faces away from the plug-in region. - a stub with a through opening for receiving the fluid line at one end of the through opening, - and a flange with a first opening for receiving the stub and a second opening for fastening to the assembly, wherein - the stub is introduced into the first opening and is connected to the flange in a material-to-material manner by means of a soldered connection, and - the flange has a plug-in region and an inner bore which faces away from the plug-in region, characterized - in that, on that surface of the plug-in region which faces the stub in the plug-in direction, the flange has a depression which runs in the circumferential direction in the region of the integrally joined connection, which depression runs radially around the first opening, and in that the solder for producing the soldered connection is applied on the inner bore which faces away from the plug-in region.
A process for the preparation of a C 8 -C 22 acyl glycinate acid or salt thereof comprising: (i) reacting a mixture of glycine or salt thereof with a fatty acid ester in a medium selected from the group consisting of glycerol, propylene glycol and combinations thereof, and wherein the mixture has a pKa ranging from 9.5 to 13; (ii) heating the mixture to form the C 8 -C 22 acyl glycinate acid or salt thereof; and (iii) recovering the C 8 -C 22 acyl glycinate acid or salt thereof in a reaction resultant mass. (i) reacting a mixture of glycine or salt thereof with a fatty acid ester in a medium selected from the group consisting of glycerol, propylene glycol and combinations thereof, and wherein the mixture has a pKa ranging from 9.5 to 13; (ii) heating the mixture to form the C 8 -C 22 acyl glycinate acid or salt thereof; and (iii) recovering the C 8 -C 22 acyl glycinate acid or salt thereof in a reaction resultant mass.
Brake system for a vehicle, wherein the brake system comprises: a first electric power supply unit; an electronic brake control unit, wherein the electronic brake control unit is connected to the first electric power supply unit; a first axle pressure modulator for service brake chambers associated with a first axle of the vehicle, wherein the first axle pressure modulator is connected to the electronic brake control unit; a second axle pressure modulator for spring brake cylinders associated with a second axle of the vehicle, wherein the second axle pressure modulator is connected to the electronic brake control unit; a second electric power supply unit; an electronic parking brake controller, wherein the electronic parking brake controller is connected to the second electric power supply unit, wherein the electronic parking brake controller is fluidically connected to the spring brake cylinders; characterized by a pressure modulator unit, wherein the pressure modulator unit is fluidically connected to the first axle pressure modulator, wherein the pressure modulator unit is connected to the electronic parking brake controller, wherein the electronic parking brake controller is configured to issue a control signal for controlling the pressure modulator unit, wherein the pressure modulator unit is configured to command pneumatic control pressure for the first axle pressure modulator depending on the control signal from the electronic parking brake controller. a first electric power supply unit; an electronic brake control unit, wherein the electronic brake control unit is connected to the first electric power supply unit; a first axle pressure modulator for service brake chambers associated with a first axle of the vehicle, wherein the first axle pressure modulator is connected to the electronic brake control unit; a second axle pressure modulator for spring brake cylinders associated with a second axle of the vehicle, wherein the second axle pressure modulator is connected to the electronic brake control unit; a second electric power supply unit; an electronic parking brake controller, wherein the electronic parking brake controller is connected to the second electric power supply unit, wherein the electronic parking brake controller is fluidically connected to the spring brake cylinders; characterized by a pressure modulator unit, wherein the pressure modulator unit is fluidically connected to the first axle pressure modulator, wherein the pressure modulator unit is connected to the electronic parking brake controller, wherein the electronic parking brake controller is configured to issue a control signal for controlling the pressure modulator unit, wherein the pressure modulator unit is configured to command pneumatic control pressure for the first axle pressure modulator depending on the control signal from the electronic parking brake controller.