A bi-directional stent delivery system (100, 500), said system comprising: an inner elongate shaft (102, 502, 602, 702, 1018) having a proximal portion and a distal portion; an outer elongate shaft (114, 514, 606, 706, 1004) having a proximal portion and a distal portion; a middle shaft (108, 508, 604, 704) disposed between and concentric with the inner and outer shafts; a radially expandable prosthesis (128, 528, 529, 616, 716) disposed over the middle shaft, the prosthesis having a radially collapsed configuration and a radially expanded configuration, wherein in the collapsed configuration the prosthesis is adapted to be delivered through a patient's vasculature, and in the expanded configuration the prosthesis engages a vessel wall; a shuttle sheath (120, 520, 610, 710, 1010) having a proximal portion and a distal portion, the shuttle sheath disposed over the radially expandable prosthesis; a distal coupling mechanism (124, 524, 612, 712, 1012, 1014) releasably coupling the distal portion of the inner shaft to the distal portion of the shuttle sheath; and a proximal coupling mechanism (122, 522, 608, 708, 1006, 1008) releasably coupling the distal portion of the outer shaft to the proximal portion of the shuttle sheath; wherein distal advancement of the inner shaft advances the shuttle sheath distally when the outer shaft is uncoupled from the shuttle sheath, thereby allowing the prosthesis to radially expand from a proximal end thereof to a distal end thereof, and wherein proximal retraction of the outer shaft retracts the shuttle sheath proximally when the inner shaft is uncoupled from the shuttle sheath, thereby allowing the prosthesis to radially expand from a distal end thereof to a proximal end thereof. an inner elongate shaft (102, 502, 602, 702, 1018) having a proximal portion and a distal portion; an outer elongate shaft (114, 514, 606, 706, 1004) having a proximal portion and a distal portion; a middle shaft (108, 508, 604, 704) disposed between and concentric with the inner and outer shafts; a radially expandable prosthesis (128, 528, 529, 616, 716) disposed over the middle shaft, the prosthesis having a radially collapsed configuration and a radially expanded configuration, wherein in the collapsed configuration the prosthesis is adapted to be delivered through a patient's vasculature, and in the expanded configuration the prosthesis engages a vessel wall; a shuttle sheath (120, 520, 610, 710, 1010) having a proximal portion and a distal portion, the shuttle sheath disposed over the radially expandable prosthesis; a distal coupling mechanism (124, 524, 612, 712, 1012, 1014) releasably coupling the distal portion of the inner shaft to the distal portion of the shuttle sheath; and a proximal coupling mechanism (122, 522, 608, 708, 1006, 1008) releasably coupling the distal portion of the outer shaft to the proximal portion of the shuttle sheath; wherein distal advancement of the inner shaft advances the shuttle sheath distally when the outer shaft is uncoupled from the shuttle sheath, thereby allowing the prosthesis to radially expand from a proximal end thereof to a distal end thereof, and wherein proximal retraction of the outer shaft retracts the shuttle sheath proximally when the inner shaft is uncoupled from the shuttle sheath, thereby allowing the prosthesis to radially expand from a distal end thereof to a proximal end thereof.