mhurhangee/ep-ind-claims huggingface dataset:
A method of identifying structures of a therapeutic protein that affect an interaction between the therapeutic protein and a target, wherein the therapeutic protein comprises an antigen-binding portion of an antibody and the target comprises an antigen for the antibody, said method comprising: a. applying a stress to a first sample comprising therapeutic proteins; b. contacting the first sample with a second sample comprising targets to form a mixture comprising (i) therapeutic protein-target complexes, (ii) unbound therapeutic proteins, and (iii) unbound targets; separating the mixture into at least two fractions, wherein an unbound fraction comprises unbound therapeutic proteins and a bound fraction comprises therapeutic protein-target complexes; c. for each of the unbound fraction and bound fraction, identifying and quantifying the abundance of a structure present on a species of the therapeutic protein, wherein the structure comprises an attribute of the therapeutic protein and, when the abundance of a structure in the unbound fraction is greater than the abundance of the structure in the bound fraction, the structure negatively affects the interaction between the therapeutic protein and the target, wherein the attribute forms as a result of a chemical modification that changes the structure of an amino acid. a. applying a stress to a first sample comprising therapeutic proteins; b. contacting the first sample with a second sample comprising targets to form a mixture comprising (i) therapeutic protein-target complexes, (ii) unbound therapeutic proteins, and (iii) unbound targets; separating the mixture into at least two fractions, wherein an unbound fraction comprises unbound therapeutic proteins and a bound fraction comprises therapeutic protein-target complexes; c. for each of the unbound fraction and bound fraction, identifying and quantifying the abundance of a structure present on a species of the therapeutic protein, wherein the structure comprises an attribute of the therapeutic protein and, when the abundance of a structure in the unbound fraction is greater than the abundance of the structure in the bound fraction, the structure negatively affects the interaction between the therapeutic protein and the target,
An antenna (210a; 210b) comprising: a reflector (220a; 220b) connected to a motor drive (240a; 240b) a primary radiator (230a, 230b; 330a, 330b; 430a, 430b) for transceiving a radio beam at an operating frequency impinged on the reflector (220a; 220b); a coarse alignment system (242a; 242b) comprising a motor drive (240a; 240b) connected to the reflector (220a; 220b) for driving at least one of the rotation and the tilting of the reflector (220a; 220b), the coarse alignment system (242a; 242b) comprising a first auxiliary antenna (250a; 250b) connected to a control device (260a; 260b) for communication with a second auxiliary antenna (250b; 250a) located at a second antenna (210b; 210a), the communication being at a second frequency different from the operating frequency; a fine alignment system (270a; 270b; 370a, 370b; 470a, 470b) for electronic adjustment of the radio beam; wherein the control device (260a; 260b) is for controlling the coarse alignment system (242a; 242b) and the fine alignment system (270a, 270b; 370a, 370b; 470a, 470b). a reflector (220a; 220b) connected to a motor drive (240a; 240b) a primary radiator (230a, 230b; 330a, 330b; 430a, 430b) for transceiving a radio beam at an operating frequency impinged on the reflector (220a; 220b); a coarse alignment system (242a; 242b) comprising a motor drive (240a; 240b) connected to the reflector (220a; 220b) for driving at least one of the rotation and the tilting of the reflector (220a; 220b), the coarse alignment system (242a; 242b) comprising a first auxiliary antenna (250a; 250b) connected to a control device (260a; 260b) for communication with a second auxiliary antenna (250b; 250a) located at a second antenna (210b; 210a), the communication being at a second frequency different from the operating frequency; a fine alignment system (270a; 270b; 370a, 370b; 470a, 470b) for electronic adjustment of the radio beam; wherein the control device (260a; 260b) is for controlling the coarse alignment system (242a; 242b) and the fine alignment system (270a, 270b; 370a, 370b; 470a, 470b).
Laundry treatment appliance comprising a housing section, a tray which can be inserted in the housing section and which has at least one compartment designed to accommodate laundry treatment agents, and comprising at least one illumination means disposed on the housing section, wherein the tray has a panel on which at least one light exit is provided, wherein a light entry associated with the light exit of the panel is provided on the tray and wherein a light exit of the illumination means is disposed on the housing section such that the light exit of the illumination means is associated with the light entry of the tray when the tray is at least substantially inserted in the housing section, characterised in that the laundry treatment appliance has a laundry treatment agent dispensing system, the at least one compartment is designed to accommodate laundry treatment agents for a plurality of program runs, a light exit being assigned to each of the one or more compartments on a front side of the panel, the laundry treatment agent is automatically dispensed from the compartment used as a storage container, wherein a control device calculates the respective quantity required and activates a dispensing device accordingly, and the control device activates the illumination means as a function of a selected operating program.
A composition for the formation of a cured epoxy resin, the composition comprising the following components, and: an epoxy resin; a clathrate compound of an isophthalic acid compound represented by formula (I-3): (wherein, R 15 represents a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a nitro group, or a hydroxy group); and an imidazole compound represented by formula: (wherein, R 1 represents a hydrogen atom, a C1 to C10 alkyl group, an aryl group, an arylalkyl group, or a cyanoethyl group, R 2 to R 4 each independently represents a hydrogen atom, a hydroxy group, a nitro group, a halogen atom, a C1 to C20 alkyl group that optionally has a hydroxy group, an aryl group, an arylalkyl group, or a C1 to C20 acyl group); and a tetrakisphenol type compound represented by formula: (wherein, X represents (CH 2) n1 or a p-phenylene group, n1 represents any integer of 0 to 3, and R 5 to R 12 each represents a hydrogen atom, a C1 to C6 alkyl group, an optionally substituted phenyl group, a halogen atom, or a C1 to C6 alkoxy group). an epoxy resin; a clathrate compound of an isophthalic acid compound represented by formula (I-3): (wherein, R 15 represents a C1 to C6 alkyl group, a C1 to C6 alkoxy group, a nitro group, or a hydroxy group); and an imidazole compound represented by formula: (wherein, R 1 represents a hydrogen atom, a C1 to C10 alkyl group, an aryl group, an arylalkyl group, or a cyanoethyl group, R 2 to R 4 each independently represents a hydrogen atom, a hydroxy group, a nitro group, a halogen atom, a C1 to C20 alkyl group that optionally has a hydroxy group, an aryl group, an arylalkyl group, or a C1 to C20 acyl group); and a tetrakisphenol type compound represented by formula: (wherein, X represents (CH 2) n1 or a p-phenylene group, n1 represents any integer of 0 to 3, and R 5 to R 12 each represents a hydrogen atom, a C1 to C6 alkyl group, an optionally substituted phenyl group, a halogen atom, or a C1 to C6 alkoxy group).
Apparatus (1a, 1b, 1c, 1d) for evacuating a system, comprising a pump for generating a decrease of pressure between its inlet and its outlet, the pump being suitable for being in connection with the system with its inlet; a pressure tank for preserving an applied pressure value; and a directional control valve for switching the pressure tank to either the inlet or the outlet of the pump, the pump transporting a medium out of the system and the pressure tank into an ambience when the pressure tank is connected to its inlet, wherein the directional control valve is configured to switch the pressure tank from the inlet to the outlet of the pump when a predefined criterion is fulfilled.
A lighting fixture comprising at least two emitters (1022/24/26/28/30/32;1104/06/08/10/12) having different wavelength characteristics and a cover (1014;1114) through which light from said at least two emitters (1022/24/26/28/30/32:1104/06/08/10/12) travels when they are activated, characterised by an optical sensor (1016;1116) arranged to sample the combined output of said at least two emitters (1022/24/26/28/30/32;1104/06/08/10/12) by detecting light that has been totally internally reflected in the cover (1014;1114), wherein the optical sensor (1016;1116) comprises a sensor responsive to colour and intensity of the internally reflected light.
A method of providing a range of nominal powers for a plurality of intraocular lenses, the method comprising: providing each lens in the plurality with essentially the same geometry; and applying to each lens in the plurality a diffractive element (13, 23, 33, 34, 43, 53, 63, 64, 73, 83, 93, 94) having a diffractive power that is different for each lens in the plurality. providing each lens in the plurality with essentially the same geometry; and applying to each lens in the plurality a diffractive element (13, 23, 33, 34, 43, 53, 63, 64, 73, 83, 93, 94) having a diffractive power that is different for each lens in the plurality.
Multi-pack with at least two containers, which are connected to one another by at least one adhesive point, wherein the containers comprise a basic body and, at the lower end, stand on support regions in the form of points, wherein - the containers exhibit a height, and wherein - with at least two adjacent containers of the multi-pack, the adhesive points are arranged, related to the height, in the lower half of the containers at transition sections from the support regions in the form of points to the basic body, characterised in that the containers are connected to one another only by the adhesive point, as well as, optionally, by a carrying handle arranged centrally at the upper end. - the containers exhibit a height, and wherein - with at least two adjacent containers of the multi-pack, the adhesive points are arranged, related to the height, in the lower half of the containers at transition sections from the support regions in the form of points to the basic body, characterised in that the containers are connected to one another only by the adhesive point, as well as, optionally, by a carrying handle arranged centrally at the upper end.
Tailgate of a motor vehicle of a type comprising an outer skin made of plastic material and an inner lining, and comprising at least one optical device provided with a glazing closing a housing, characterized in that at least one first assembly area between the housing and the glazing is located under the outer skin, the glazing being fixed on an inner surface of the outer skin at the level of the first assembly area, for example by gluing, the housing being borne by the inner lining.
A system for evaluating a pain disorder comprising: an electrogram interface that receives a recorded evoked potential from an electrogram of a subject; a feature extractor that extracts a set of features from the evoked potential including features from at least two of a set of features representing connectivity between regions of the brain, a set of morphology features, a set of features representing time and frequency, a set of signal decomposition features, and a set of features representing entropy; a machine learning model configured to be trained on a set of training samples that each comprise values for the extracted set of features and a value for a clinical parameter from a set of subjects having a known value for the clinical parameter, the machine learning model further configured to assign the clinical parameter to the subject from the extracted set of features, the clinical parameter representing one of the presence of a pain disorder generally, the presence of a specific pain disorder, a subtype of a pain disorder, a severity of a pain disorder, a change in the severity of a pain disorder over time, and a likelihood that the subject suffers from a specific pain disorder, the clinical parameter configured to be a categorical parameter that can assume a value associated with one of a plurality of classes, each class representing one of the presence of the pain disorder, and the likelihood that the subject suffers from the pain disorder; and an output device configured to provide the clinical parameter to a user. an electrogram interface that receives a recorded evoked potential from an electrogram of a subject; a feature extractor that extracts a set of features from the evoked potential including features from at least two of a set of features representing connectivity between regions of the brain, a set of morphology features, a set of features representing time and frequency, a set of signal decomposition features, and a set of features representing entropy; a machine learning model configured to be trained on a set of training samples that each comprise values for the extracted set of features and a value for a clinical parameter from a set of subjects having a known value for the clinical parameter, the machine learning model further configured to assign the clinical parameter to the subject from the extracted set of features, the clinical parameter representing one of the presence of a pain disorder generally, the presence of a specific pain disorder, a subtype of a pain disorder, a severity of a pain disorder, a change in the severity of a pain disorder over time, and a likelihood that the subject suffers from a specific pain disorder, the clinical parameter configured to be a categorical parameter that can assume a value associated with one of a plurality of classes, each class representing one of the presence of the pain disorder, and the likelihood that the subject suffers from the pain disorder; and an output device configured to provide the clinical parameter to a user.
A method of determining composition of an aqueous solution, comprising: obtaining the aqueous solution comprising a concentration of hydrogen peroxide and a concentration of dissolved oxygen; removing oxygen from at least a portion of the aqueous solution to produce a first sample; determining a first sample concentration of dissolved oxygen in the first sample; removing hydrogen peroxide from at least a portion of the first sample to produce a second sample; determining a second sample concentration of dissolved oxygen in the second sample; calculating a difference between the second sample concentration of dissolved oxygen and the first sample concentration of dissolved oxygen to determine the concentration of hydrogen peroxide in the aqueous solution; characterised by; further comprising multiplying the difference between the second sample concentration of dissolved oxygen and the first sample concentration of dissolved oxygen by 2.125 to determine the concentration of hydrogen peroxide in the aqueous solution. obtaining the aqueous solution comprising a concentration of hydrogen peroxide and a concentration of dissolved oxygen; removing oxygen from at least a portion of the aqueous solution to produce a first sample; determining a first sample concentration of dissolved oxygen in the first sample; removing hydrogen peroxide from at least a portion of the first sample to produce a second sample; determining a second sample concentration of dissolved oxygen in the second sample; calculating a difference between the second sample concentration of dissolved oxygen and the first sample concentration of dissolved oxygen to determine the concentration of hydrogen peroxide in the aqueous solution; characterised by; further comprising multiplying the difference between the second sample concentration of dissolved oxygen and the first sample concentration of dissolved oxygen by 2.125 to determine the concentration of hydrogen peroxide in the aqueous solution.
Pull-out guide comprising a stationary guide rail and a running rail (4, 4', 4") that can be moved relative to the guide rail, whereby a retraction device is provided between the running rail (4, 4', 4") and the guide rail, which is arranged between the running rail (4, 4', 4") and the guide rail in the retracted position of the pull-out guide, whereby the guide rail and the running rail (4, 4', 4") are C- or U-shaped in cross section and the C- or U-shaped legs of the guide rail and the running rail (4, 4', 4") are facing each other, whereby the retraction device comprises a housing, in which a guide for a linearly movable slider (7, 7') and a guide track for a driver (11, 11', 11", 11''') attached to the slider (7, 7') are provided, wherein the driver (11, 11', 11". 11''') can be coupled with an activator and between the housing and the slider (7, 7') a damper comprising a damper housing and a piston rod is provided, whereby around the damper a spring is arranged by means of which the slider (7, 7') is pretensioned on the housing in a retracted position.
A process for producing rigid polyurethane foams by reaction of A) one or more organic polyisocyanates, B) one or more polyester polyols, C) optionally one or more polyether polyols, D) a flame-retardant mixture, E) further auxiliaries or addition agents, F) one or more blowing agents, and also G) catalysts, wherein said flame-retardant mixture D) comprises d1) 10 to 90 wt%, based on the amount of flameretardant mixture, of a flame retardant having a boiling point of not more than 220°C, and d2) 10 to 90 wt%, based on the amount of flame-retardant mixture, of a phosphorus-containing flame retardant having a boiling point of above 220°C, wherein said components d1) and d2) total 100 wt%, and said polyester polyol B) comprises at least one polyetherester polyol comprising the esterification product of b1) 10 to 70 mol% of a dicarboxylic acid composition comprising b11) 50 to 100 mol%, based on the dicarboxylic acid composition, of one or more aromatic dicarboxylic acids or derivatives thereof, b12) 0 to 50 mol%, based on said dicarboxylic acid composition b1), of one or more aliphatic dicarboxylic acids or derivatives thereof, b2) 2 to 30 mol% of one or more fatty acids and/or fatty acid derivatives, b3) 10 to 70 mol% of one or more aliphatic or cycloaliphatic diols having 2 to 18 carbon atoms or alkoxylates thereof, b4) 2 to 50 mol% of a polyether polyol having a functionality of not less than 2, prepared by alkoxylating a polyol having a functionality of not less than 2, all based on the total amount of components b1) to b4), wherein said components b1) to b4) sum to 100 mol%. A) one or more organic polyisocyanates, B) one or more polyester polyols, C) optionally one or more polyether polyols, D) a flame-retardant mixture, E) further auxiliaries or addition agents, F) one or more blowing agents, and also G) catalysts, d1) 10 to 90 wt%, based on the amount of flameretardant mixture, of a flame retardant having a boiling point of not more than 220°C, and d2) 10 to 90 wt%, based on the amount of flame-retardant mixture, of a phosphorus-containing flame retardant having a boiling point of above 220°C, b1) 10 to 70 mol% of a dicarboxylic acid composition comprising b11) 50 to 100 mol%, based on the dicarboxylic acid composition, of one or more aromatic dicarboxylic acids or derivatives thereof, b12) 0 to 50 mol%, based on said dicarboxylic acid composition b1), of one or more aliphatic dicarboxylic acids or derivatives thereof, b11) 50 to 100 mol%, based on the dicarboxylic acid composition, of one or more aromatic dicarboxylic acids or derivatives thereof, b12) 0 to 50 mol%, based on said dicarboxylic acid composition b1), of one or more aliphatic dicarboxylic acids or derivatives thereof, b2) 2 to 30 mol% of one or more fatty acids and/or fatty acid derivatives, b3) 10 to 70 mol% of one or more aliphatic or cycloaliphatic diols having 2 to 18 carbon atoms or alkoxylates thereof, b4) 2 to 50 mol% of a polyether polyol having a functionality of not less than 2, prepared by alkoxylating a polyol having a functionality of not less than 2,
A method for attaching one or more polynucleotide binding proteins to a target polynucleotide, comprising: (a) providing the one or more polynucleotide binding proteins bound to one or more loading moieties comprising a loading polynucleotide, wherein the one or more polynucleotide binding proteins are bound to the loading polynucleotide; and (b) attaching the one or more loading moieties to the target polynucleotide, wherein the one or more polynucleotide binding proteins remain bound to the one or more loading moieties. (a) providing the one or more polynucleotide binding proteins bound to one or more loading moieties comprising a loading polynucleotide, wherein the one or more polynucleotide binding proteins are bound to the loading polynucleotide; and (b) attaching the one or more loading moieties to the target polynucleotide, wherein the one or more polynucleotide binding proteins remain bound to the one or more loading moieties.
A grinder resistant lock including: (a) a U-lock comprising (i) a U-shaped shackle made of a hardened metal and exhibiting first and second arms on either side of a centrally located curved portion, and (ii) a lockable crossbar that releasably engages a terminal end on each of the shackle first and second arms; and (b) a shackle shell over and around substantially the entire length of the shackle and being made from a material that is softer than the shackle steel and sufficiently thick to clog a coarse grit cutting wheel when contacting said shell and thereby reducing the cutting efficiency of the cutting wheel; the grinder resistant lock being characterized in that said shackle shell is in the form of two U-shaped half shell sections (7, 8), each half having a groove of a width and length to fit the U-shaped shackle, each shackle shell section (7, 8) further exhibiting internal fins that extend radially away from said groove. (a) a U-lock comprising (i) a U-shaped shackle made of a hardened metal and exhibiting first and second arms on either side of a centrally located curved portion, and (ii) a lockable crossbar that releasably engages a terminal end on each of the shackle first and second arms; and (b) a shackle shell over and around substantially the entire length of the shackle and being made from a material that is softer than the shackle steel and sufficiently thick to clog a coarse grit cutting wheel when contacting said shell and thereby reducing the cutting efficiency of the cutting wheel;
A sand mixing device having a mixing bowl which is arranged stationarily on a support frame and includes a peripheral side wall and a bottom wall, a central mixing tool being arranged rotatably about a central mixer axis of the mixing bowl and having a number of blades extending along the bottom wall to the peripheral side wall, and at least one peripheral mixing tool (9, 11) being arranged rotatably about a peripheral mixer axis (10, 12), characterised in that the mixing bowl is arranged in an inclined position on the support frame so that the central mixer axis of the mixing bowl is inclined at an angle to the vertical, in that a first cross-sectional plane extending through the mixing bowl and including both the central mixer axis and a horizontal line extending in a plane defining the bottom wall divides the mixing bowl into a lower part positioned relatively lower and a higher part positioned relatively higher, and in that at least one peripheral mixing tool (9, 11) is arranged in the lower part of the mixing bowl.