mhurhangee/ep-ind-claims huggingface dataset:
Toggle fixing for fixing an article to a thin-walled component, having a crosspiece and a strip which is joined to the crosspiece and serves for holding the crosspiece during mounting, wherein the crosspiece extends along a crosspiece longitudinal axis, and wherein the crosspiece has an opening for receiving a screw, the opening extending along an opening longitudinal axis transversely with respect to the crosspiece longitudinal axis, wherein on the crosspiece there is arranged at least one counterbearing element made of metal for engagement in the thread of the screw, which element narrows the opening, characterised in that on the side of the counterbearing element facing towards the strip there is arranged a plastics body which is movably joined to the crosspiece, especially via a rib or a film hinge, and narrows the opening.
Electrically operated aerosol-generating device (100, 200) for generating an aerosol, the device (100, 200) comprising: - a receiving cavity (120, 220) for removably receiving an aerosol-forming substrate or at least a portion of an aerosol-generating article comprising an aerosol-forming substrate; - an air path (180, 181) which extends through the device (100, 200) and is configured to support an airflow (182, 282) in the device (100, 200); - a sound generating member (160, 260) which is arranged in fluid communication with the air path (180, 181) and configured to generate sound caused by an airflow (182, 282) passing the sound generating member (160, 260) in use of the device (100, 200) when a user takes a puff, wherein the sound generating member (160, 260) is located in a distal end portion of the receiving cavity (120, 220); and - a puff detector comprising a vibration sensor (170, 270), wherein the vibration sensor (170, 270) is fluidly separated from the air path (180, 181) and configured to detect the sound propagating from the sound generating member (160, 260) to the vibration sensor (170, 270). - a receiving cavity (120, 220) for removably receiving an aerosol-forming substrate or at least a portion of an aerosol-generating article comprising an aerosol-forming substrate; - an air path (180, 181) which extends through the device (100, 200) and is configured to support an airflow (182, 282) in the device (100, 200); - a sound generating member (160, 260) which is arranged in fluid communication with the air path (180, 181) and configured to generate sound caused by an airflow (182, 282) passing the sound generating member (160, 260) in use of the device (100, 200) when a user takes a puff, wherein the sound generating member (160, 260) is located in a distal end portion of the receiving cavity (120, 220); and - a puff detector comprising a vibration sensor (170, 270), wherein the vibration sensor (170, 270) is fluidly separated from the air path (180, 181) and configured to detect the sound propagating from the sound generating member (160, 260) to the vibration sensor (170, 270).
Starting device for sports with means to obtain positional control, comprising a platform and a support movable on the platform, characterised in that the support has an angular constitution with a lower horizontal section which moves guided on the platform and which has, on its lower part, a protrusion which selectively fits into aligned openings provided in the platform, the indicated horizontal section comprising two pins (6, 7), one front pin and another rear pin, having play in respective slots (8, 9) of the guide, the rear pin being coupled in a vertical slot provided in said horizontal section of the support.
A method of operating a power supply operable at a configurable switching frequency for a low-jitter oscillatory system, comprising: identifying a state of a clock detector control signal generated by a clock detector adapted to detect the output clock of said low-jitter oscillatory system; and adaptively selecting (208b, 214b) the configurable switching frequency for the power supply between a reference clock oscillator output signal and a low-jitter oscillatory system output signal based on the state of the clock detector control signal to mitigate effects of period jitter in the low-jitter oscillatory system output signal when said clock detector control signal is asserted. identifying a state of a clock detector control signal generated by a clock detector adapted to detect the output clock of said low-jitter oscillatory system; and adaptively selecting (208b, 214b) the configurable switching frequency for the power supply between a reference clock oscillator output signal and a low-jitter oscillatory system output signal based on the state of the clock detector control signal to mitigate effects of period jitter in the low-jitter oscillatory system output signal when said clock detector control signal is asserted.
A plate-like body with a resin frame attached thereto, which has the resin frame integrally formed on a peripheral portion of the plate-like body by injection molding, wherein the resin frame includes a solid thick wall part with an imaginary inscribed circle inscribed in the resin frame, and wherein the imaginary inscribed circle has a diameter of at least of 7 mm, characterized in that the resin frame has a pressed mark at least partly formed on an invisible surface side thereof.
Assembly for boring holes (18, 19) for implants in the jaw of a patient in collaboration with a surgical drilling guide, said assembly comprising: - a surgical drilling guide comprising a first tubular drilling sleeve with a first inside diameter and a second tubular drilling sleeve with a second inside diameter, - a drill bit extending in a longitudinal direction (I-I) between a proximal end and a free distal end with a proximal connection portion for connection to a dental handpiece and a distal cutting portion that has an outside diameter (D5d) less than or equal to the first inside diameter, said drill bit comprising, between its proximal connection portion and distal cutting portion, an intermediate cylindrical guide portion, - an adapter bushing having an inside diameter able to accept, with a small amount of clearance, the intermediate guide portion of the drill bit, characterized in that: - the second inside diameter is greater than the first inside diameter, - the intermediate cylindrical guide portion is able to fit with a small amount of clearance on its outside diameter (D5e) into the first tubular drilling sleeve, - the adapter bushing is able to fit with a small amount of clearance on an outside diameter (D6a) of an engagement portion into the second tubular drilling sleeve. - a surgical drilling guide comprising a first tubular drilling sleeve with a first inside diameter and a second tubular drilling sleeve with a second inside diameter, - a drill bit extending in a longitudinal direction (I-I) between a proximal end and a free distal end with a proximal connection portion for connection to a dental handpiece and a distal cutting portion that has an outside diameter (D5d) less than or equal to the first inside diameter, said drill bit comprising, between its proximal connection portion and distal cutting portion, an intermediate cylindrical guide portion, - an adapter bushing having an inside diameter able to accept, with a small amount of clearance, the intermediate guide portion of the drill bit, - the second inside diameter is greater than the first inside diameter, - the intermediate cylindrical guide portion is able to fit with a small amount of clearance on its outside diameter (D5e) into the first tubular drilling sleeve, - the adapter bushing is able to fit with a small amount of clearance on an outside diameter (D6a) of an engagement portion into the second tubular drilling sleeve.
A system for utilizing unused heat-exchange water of a passive auxiliary feedwater system, the system comprising: a steam generator to generate steam by heat from a nuclear reactor; a passive condensation tank in which heat-exchange water is stored; a condenser arranged inside the passive condensation tank and spaced apart from a bottom part of the passive condensation tank; a steam supply line arranged between the steam generator and an inlet of the condenser inside the passive condensation tank and providing a pipeline for cutting off steam supply to a turbine side and branching the steam off to the condenser when an operation of the nuclear reactor is stopped; and a condensate water recovery line arranged between an outlet of the condenser and the steam generator and providing a pipeline for recovering condensate water through the condenser to the steam generator, characterized in that a residual water discharge flow path is arranged between the passive condensation tank and the condensate water recovery line and discharges remaining water remaining between the condenser and the bottom part of the passive condensation tank to the condensate water recovery line; the passive condensation tank is provided with a water level measuring sensor to measure a level of heat-exchange water therein, and the residual water discharge flow path is provided with an automatic valve therein; and the automatic valve adapted to automatically open the residual water discharge flow path based on water level detection of the water level measuring sensor. a steam generator to generate steam by heat from a nuclear reactor; a passive condensation tank in which heat-exchange water is stored; a condenser arranged inside the passive condensation tank and spaced apart from a bottom part of the passive condensation tank; a steam supply line arranged between the steam generator and an inlet of the condenser inside the passive condensation tank and providing a pipeline for cutting off steam supply to a turbine side and branching the steam off to the condenser when an operation of the nuclear reactor is stopped; and a condensate water recovery line arranged between an outlet of the condenser and the steam generator and providing a pipeline for recovering condensate water through the condenser to the steam generator, characterized in that a residual water discharge flow path is arranged between the passive condensation tank and the condensate water recovery line and discharges remaining water remaining between the condenser and the bottom part of the passive condensation tank to the condensate water recovery line; the passive condensation tank is provided with a water level measuring sensor to measure a level of heat-exchange water therein, and the residual water discharge flow path is provided with an automatic valve therein; and the automatic valve adapted to automatically open the residual water discharge flow path based on water level detection of the water level measuring sensor.
A medical device for closing an anatomical aperture comprising: a plug body having a proximal end, a distal end, and a longitudinal axis, the plug body comprising: an exterior surface; an interior surface defining an interior lumen; and a seal located within the interior lumen; and at least one arm member (100, 200) extending through the plug body between the exterior surface and the interior surface of the plug body, wherein the at least one arm member comprises at least one loop (100, 200), wherein the at least one loop (100, 200) comprises a distal loop extending through the plug body and a proximal loop extending through the plug body, wherein the distal and proximal loops (100, 200) are oriented generally perpendicular to the longitudinal axis of the plug body, wherein the distal loop includes a top end, a middle portion and a bottom end and the proximal loop includes a top end, a middle portion, and a bottom end, and wherein the top end and bottom end of distal loop are angled toward the proximal end of plug, and the top end and bottom end of proximal loop can be angled toward the distal end of plug. an exterior surface; an interior surface defining an interior lumen; and a seal located within the interior lumen; and at least one arm member (100, 200) extending through the plug body between the exterior surface and the interior surface of the plug body, wherein the at least one arm member comprises at least one loop (100, 200), wherein the at least one loop (100, 200) comprises a distal loop extending through the plug body and a proximal loop extending through the plug body, wherein the distal and proximal loops (100, 200) are oriented generally perpendicular to the longitudinal axis of the plug body, wherein the distal loop includes a top end, a middle portion and a bottom end and the proximal loop includes a top end, a middle portion, and a bottom end, and wherein the top end and bottom end of distal loop are angled toward the proximal end of plug, and the top end and bottom end of proximal loop can be angled toward the distal end of plug.
A medical instrument, comprising: a shaft; a handle connected to the shaft; and a tool insert receivable in the shaft; wherein the tool insert includes a tool portion and an elongated member for engagement with the handle for actuation of the tool portion; wherein the shaft includes a threaded portion on a distal end thereof; wherein the tool insert includes a collar rotatable relative to the tool insert; and wherein the collar includes threads that correspond to the threaded portion of the shaft; characterized in that: the shaft includes at least one slot (30a, 30b) on its distal end, the at least one slot (30a, 30b) forming at least one protrusion of the shaft, the tool portion includes at least one protrusion for engagement with the at least one slot (30a, 30b) of the shaft to substantially prevent rotation of the tool portion relative to the shaft, and the at least one protrusion of the shaft and the at least one protrusion of the tool portion each comprise inclined surfaces. a shaft; a handle connected to the shaft; and a tool insert receivable in the shaft; wherein the tool insert includes a tool portion and an elongated member for engagement with the handle for actuation of the tool portion; wherein the shaft includes a threaded portion on a distal end thereof; wherein the tool insert includes a collar rotatable relative to the tool insert; and wherein the collar includes threads that correspond to the threaded portion of the shaft; characterized in that: the shaft includes at least one slot (30a, 30b) on its distal end, the at least one slot (30a, 30b) forming at least one protrusion of the shaft, the tool portion includes at least one protrusion for engagement with the at least one slot (30a, 30b) of the shaft to substantially prevent rotation of the tool portion relative to the shaft, and the at least one protrusion of the shaft and the at least one protrusion of the tool portion each comprise inclined surfaces. the shaft includes at least one slot (30a, 30b) on its distal end, the at least one slot (30a, 30b) forming at least one protrusion of the shaft, the tool portion includes at least one protrusion for engagement with the at least one slot (30a, 30b) of the shaft to substantially prevent rotation of the tool portion relative to the shaft, and the at least one protrusion of the shaft and the at least one protrusion of the tool portion each comprise inclined surfaces.
A delivery catheter for a prosthetic heart valve, the valve expandable from a collapsed condition for delivery to an expanded condition for implantation, the delivery catheter comprising: a holder for engaging the valve in the collapsed state of the valve; and a sheath (24, 120) translatable with respect to the holder between a first position in which the sheath (24, 120) surrounds at least a first portion of the holder, and a second position in which the sheath (24, 120) does not surround the first portion of the holder and wherein the sheath (24, 120) translates in a distal direction of the delivery catheter when moving from the first position to the second position; characterized in that the delivery catheter further comprises an interface member biased towards a radially expanded condition for (i) bridging a gap between the holder and the sheath (24, 120) when in the second position, and/or (ii) defining a generally smooth interface surface between the holder and the sheath (24, 120) when in the second position. a holder for engaging the valve in the collapsed state of the valve; and a sheath (24, 120) translatable with respect to the holder between a first position in which the sheath (24, 120) surrounds at least a first portion of the holder, and a second position in which the sheath (24, 120) does not surround the first portion of the holder and wherein the sheath (24, 120) translates in a distal direction of the delivery catheter when moving from the first position to the second position; characterized in that the delivery catheter further comprises an interface member biased towards a radially expanded condition for (i) bridging a gap between the holder and the sheath (24, 120) when in the second position, and/or (ii) defining a generally smooth interface surface between the holder and the sheath (24, 120) when in the second position.
A method of detecting a therapeutic drug response in a mammal treated with an IBD therapeutic agent, wherein the method comprises determining and comparing LY6 expression levels in a test sample comprising gastrointestinal tissue or cells of said mammal prior to and after treatment with said IBD therapeutic agent, wherein a lower level of LY6 expression in the test sample after the treatment indicates a response of the mammal to said therapeutic agent.
A beverage machine for the preparation of beverages comprising: - a frame, - a beverage outlet adapted to deliver a beverage in a recipient separate from such machine and placed in a beverage service area, - a drip collecting means which is configured to be selectively placed below or around the said beverage outlet to collect liquid or froth when the machine is not delivering the beverage and/or when said recipient is removed from the beverage service area, the drip collecting means being mobile between a collecting position in which it is placed under the said outlet and a retracted position in which it is placed away relative to the vertical of the said outlet, characterised in that such machine comprises a control unit and an actuation means, the drip collecting means being associated to the actuation means which is controlled by the control unit to move the drip collection means from the collecting position to the retracted position and vice versa. - a frame, - a beverage outlet adapted to deliver a beverage in a recipient separate from such machine and placed in a beverage service area, - a drip collecting means which is configured to be selectively placed below or around the said beverage outlet to collect liquid or froth when the machine is not delivering the beverage and/or when said recipient is removed from the beverage service area,
A method for producing an antigen-binding molecule with enhanced intracellular uptake of antigens that bind to the antigen binding molecule, which comprises the steps of: (a) determining the antigen-binding activity of an antigen-binding domain or of an antibody under a high-calcium-ion concentration condition; (b) determining the antigen-binding activity of an antigen-binding domain or of an antibody under a low-calcium-ion concentration condition; (c) selecting the antigen-binding domain or the antibody for which the antigen-binding activity determined in (a) is higher than the antigen-binding activity determined in (b); (d) linking a polynucleotide encoding the antigen-binding domain or the antigen-binding domain of the antibody selected in (c) to a polynucleotide encoding an Fcγ receptor-binding domain having human-FcRn-binding activity in an acidic pH range condition and in which binding activity to the Fcγ receptor in a neutral pH range condition is higher than that of an Fc region of a native human IgG in which the sugar chain bound at position 297 according to EU numbering is a fucose-containing sugar chain; (e) culturing cells, except for human embryonal stem cells, introduced with a vector in which the polynucleotide obtained in (d) is operably linked; and (f) collecting antigen-binding molecules from the cell culture of (e), wherein the Fcγ receptor-binding domain comprises an IgG Fc region, and wherein the antigen-binding domain comprises an antibody variable region, wherein the Fc region is an Fc region in which an amino acid at position 238 in the Fc region site according to EU numbering is altered from Pro at corresponding sites in a native Fc region to any one of Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, and Tyr. (a) determining the antigen-binding activity of an antigen-binding domain or of an antibody under a high-calcium-ion concentration condition; (b) determining the antigen-binding activity of an antigen-binding domain or of an antibody under a low-calcium-ion concentration condition; (c) selecting the antigen-binding domain or the antibody for which the antigen-binding activity determined in (a) is higher than the antigen-binding activity determined in (b); (d) linking a polynucleotide encoding the antigen-binding domain or the antigen-binding domain of the antibody selected in (c) to a polynucleotide encoding an Fcγ receptor-binding domain having human-FcRn-binding activity in an acidic pH range condition and in which binding activity to the Fcγ receptor in a neutral pH range condition is higher than that of an Fc region of a native human IgG in which the sugar chain bound at position 297 according to EU numbering is a fucose-containing sugar chain; (e) culturing cells, except for human embryonal stem cells, introduced with a vector in which the polynucleotide obtained in (d) is operably linked; and (f) collecting antigen-binding molecules from the cell culture of (e),
Method for controlling an automated parking operation, in which a motor vehicle is controlled autonomously on a route between a handover point and a parking space, wherein the method comprises the following steps: a) recording the fact that a person is on board the motor vehicle during an autonomous driving procedure; b) determining that there is not permission to transport the person on the journey; and c) performing one or more actions; wherein transporting the person may be permitted upon a request, wherein the request is rejected only when a traffic situation in the region of the parking operation is classified as hazardous. a) recording the fact that a person is on board the motor vehicle during an autonomous driving procedure; b) determining that there is not permission to transport the person on the journey; and c) performing one or more actions;