A carboline derivative, or the pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers thereof, wherein the structure of the carboline derivative is of formula I: wherein, A is aryl, heteroaryl, or 3- to 12-membered monocyclic or polycyclic heterocyclic ring, wherein the heterocyclic ring contains 0-4 heteroatoms each independently being N, O, S, S or S 2; R 1 and R 2 together with the carbon atom to which they are attached form a 3- to 9-membered ring; R 3 and R 4 are each independently hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, C 3-8 epoxyalkyl, aryl, heteroaryl, or 3- to 12-membered heterocyclic group; R 5 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 6 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 7 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 8 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl; R 9 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl; wherein each of the above-mentioned alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl, heteroaryl, 3- to 9-membered ring is optionally and each independently substituted with one or more substituents, and the substituents are each independently halogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, 3- to 12- membered heterocyclic group, aryl, heteroaryl, CN, NO 2, =O, or =S; with the proviso that the compound is not -8-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-10-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-1H-furo[3,4-g]pyrido[3,2-b]indol-3 -one. A is aryl, heteroaryl, or 3- to 12-membered monocyclic or polycyclic heterocyclic ring, wherein the heterocyclic ring contains 0-4 heteroatoms each independently being N, O, S, S or S 2; R 1 and R 2 together with the carbon atom to which they are attached form a 3- to 9-membered ring; R 3 and R 4 are each independently hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, C 3-8 epoxyalkyl, aryl, heteroaryl, or 3- to 12-membered heterocyclic group; R 5 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 6 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 7 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl, aryl, heteroaryl, or 3- to 12- membered heterocyclic group; R 8 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl; R 9 is selected from the group consisting of hydrogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 1-8 alkoxy, C 1-8 alkoxy carbonyl; wherein each of the above-mentioned alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl, heteroaryl, 3- to 9-membered ring is optionally and each independently substituted with one or more substituents, and the substituents are each independently halogen, halogen, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, 3- to 12- membered heterocyclic group, aryl, heteroaryl, CN, NO 2, =O, or =S; with the proviso that the compound is not -8-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-10-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-1H-furo[3,4-g]pyrido[3,2-b]indol-3 -one.