mhurhangee/ep-ind-claims huggingface dataset:
An Apical Sodium-dependent Bile Acid Transport Inhibitor (ASBTI) for use in a method of increasing growth in a pediatric subject having a cholestatic liver disease, the method comprising administering to the subject an effective amount of the ASBTI, wherein the ASBTI is (maralixibat) or a pharmaceutically acceptable alternative salt thereof; and wherein the ASBTI is administered in an amount of about 140 μg/kg/day to about 2000 μg/kg/day.
An avalanche triggering system including: - a portable unit configured to be carried by an operator, the portable unit comprising a gas storage device configured to store an oxidizing gas and a combustible gas, - an explosion unit which is configured to be launched by the operator and which is fluidly connected to the portable unit, the explosion unit including a flexible envelope which is configured to be at least partially filled with an explosive gas mixture formed by combustible gas and oxidizing gas coming from the gas storage device, the flexible envelope being deformable between a rest configuration in which the flexible envelope has a first inner volume and an inflated configuration in which the flexible envelope has a second inner volume which is greater than the first inner volume and is at least partially filled with the explosive gas mixture, the explosion unit further comprising an ignition device which is configured to trigger the explosion of the explosive gas mixture contained in the flexible envelope, and - a control unit which is configured to remotely control the ignition device. - a portable unit configured to be carried by an operator, the portable unit comprising a gas storage device configured to store an oxidizing gas and a combustible gas, - an explosion unit which is configured to be launched by the operator and which is fluidly connected to the portable unit, the explosion unit including a flexible envelope which is configured to be at least partially filled with an explosive gas mixture formed by combustible gas and oxidizing gas coming from the gas storage device, the flexible envelope being deformable between a rest configuration in which the flexible envelope has a first inner volume and an inflated configuration in which the flexible envelope has a second inner volume which is greater than the first inner volume and is at least partially filled with the explosive gas mixture, the explosion unit further comprising an ignition device which is configured to trigger the explosion of the explosive gas mixture contained in the flexible envelope, and - a control unit which is configured to remotely control the ignition device.
A monoclonal antibody or antibody fragment that specifically binds to a human Siglec-10 polypeptide, wherein the antibody is capable of inhibiting the interactions between a Siglec-10 polypeptide and a human MDA-MB-231 and/or A375 cancer cell, wherein the antibody competes for binding to a human Siglec-10 polypeptide with an antibody selected from the group consisting of: (a) an antibody having respectively a VH and VL region of SEQ ID NOS: 12 and 13; (b) an antibody having respectively a VH and VL region of SEQ ID NOS: 20 and 21; and (c) an antibody having respectively a VH and VL region of SEQ ID NOS: 28 and 29. (a) an antibody having respectively a VH and VL region of SEQ ID NOS: 12 and 13; (b) an antibody having respectively a VH and VL region of SEQ ID NOS: 20 and 21; and (c) an antibody having respectively a VH and VL region of SEQ ID NOS: 28 and 29.
A process for making an antifouling coating composition comprising the following steps: a) preparation of a binder polymer in an organic solvent; b) emulsification of the binder polymer and the organic solvent into water to produce an oil in water emulsion; c) removal of part of the organic solvent from the emulsion; and d) formulation of the emulsion into a water-based anti-fouling coating composition. a) preparation of a binder polymer in an organic solvent; b) emulsification of the binder polymer and the organic solvent into water to produce an oil in water emulsion; c) removal of part of the organic solvent from the emulsion; and d) formulation of the emulsion into a water-based anti-fouling coating composition.
A method for processing radioactive waste stored in a container by means of pyrolysis to be carried out in a reaction chamber, comprising the method steps of: - separating the container into at least two container parts (24, 26), - introducing the container parts into the reaction chamber, in which a steamcontaining atmosphere is set to a temperature T where T ≥ 200°C, wherein a container part (24, 26) is positioned on a receptacle comprising perforations by its separation surface and is introduced into the reaction chamber, - carrying out the pyrolysis, - removing gases (exhaust gas) from the reaction chamber, - removing the receptacle from the reaction chamber, wherein, in addition, at least one method step from the following group is carried out: - introducing oxygen and/or CO 2 into the reaction chamber during the pyrolysis in an under-stoichiometric or maximum stoichiometric quantity, - adjusting steam or CO 2 to be introduced into the reaction chamber on the basis of oxidizable substance in the exhaust gas, - adjusting oxygen and/or CO 2 to be introduced into the reaction chamber on the basis of oxidizable substance in the exhaust gas, - stopping the pyrolysis on the basis of oxidizable substance present in the exhaust gas, - introducing steam and/or oxygen and/or CO 2 into the radioactive waste or in the region thereof in a targeted manner, - conducting steam and/or oxygen and/or CO 2 within the reaction chamber in a targeted manner. - separating the container into at least two container parts (24, 26), - introducing the container parts into the reaction chamber, in which a steamcontaining atmosphere is set to a temperature T where T ≥ 200°C, wherein a container part (24, 26) is positioned on a receptacle comprising perforations by its separation surface and is introduced into the reaction chamber, - carrying out the pyrolysis, - removing gases (exhaust gas) from the reaction chamber, - removing the receptacle from the reaction chamber, - introducing oxygen and/or CO 2 into the reaction chamber during the pyrolysis in an under-stoichiometric or maximum stoichiometric quantity, - adjusting steam or CO 2 to be introduced into the reaction chamber on the basis of oxidizable substance in the exhaust gas, - adjusting oxygen and/or CO 2 to be introduced into the reaction chamber on the basis of oxidizable substance in the exhaust gas, - stopping the pyrolysis on the basis of oxidizable substance present in the exhaust gas, - introducing steam and/or oxygen and/or CO 2 into the radioactive waste or in the region thereof in a targeted manner, - conducting steam and/or oxygen and/or CO 2 within the reaction chamber in a targeted manner.
A process for manufacturing a coating composition, wherein the process comprises the steps of: (i) forming a reaction mixture comprising water, first quaternary silane and second quaternary silane, wherein the first quaternary silane has formula, Si(R 1) 4 wherein each R 1 is independently selected from alkoxy and halogen; and the second quaternary silane has formula, (R 1) 4-m Si(R 2) m wherein each R 1 is independently selected from alkoxy and halogen; R 2 comprises at least 2 carbon atoms and is selected from alkyl, alkenyl, fluoroalkyl, fluoroalkenyl, aryl, fluoroaryl and combinations thereof; and m is an integer from 1 to 3, preferably 1 or 2; (ii) hydrolyzing the reaction mixture under basic conditions; and then (iii) continuing the hydrolysis under acidic conditions. (i) forming a reaction mixture comprising water, first quaternary silane and second quaternary silane, wherein the first quaternary silane has formula, Si(R 1) 4 wherein each R 1 is independently selected from alkoxy and halogen; and the second quaternary silane has formula, (R 1) 4-m Si(R 2) m wherein each R 1 is independently selected from alkoxy and halogen; R 2 comprises at least 2 carbon atoms and is selected from alkyl, alkenyl, fluoroalkyl, fluoroalkenyl, aryl, fluoroaryl and combinations thereof; and m is an integer from 1 to 3, preferably 1 or 2; (ii) hydrolyzing the reaction mixture under basic conditions; and then (iii) continuing the hydrolysis under acidic conditions.
A method of diagnosing melanoma in an individual, comprising (a) analyzing a biological sample from the individual, (b) detecting the presence of a nucleic acid encoding a DDR2 protein having a mutation or the presence of a DDR2 protein having a mutation, wherein the mutation is selected from the group consisting of R105C, P321L, R458H, S467F, P476S, I488S, F574C, S667F, S674F, R680L, L701F, R742Q, and T836A in the sample, and (c) diagnosing the individual as having melanoma when the mutation is detected, thereby indicating that the individual has melanoma. (a) analyzing a biological sample from the individual, (b) detecting the presence of a nucleic acid encoding a DDR2 protein having a mutation or the presence of a DDR2 protein having a mutation, wherein the mutation is selected from the group consisting of R105C, P321L, R458H, S467F, P476S, I488S, F574C, S667F, S674F, R680L, L701F, R742Q, and T836A in the sample, and (c) diagnosing the individual as having melanoma when the mutation is detected, thereby indicating that the individual has melanoma.
Longitudinal cutter cassette having a blade shaft, on which at least one longitudinal cutting blade is arranged, and having a housing (25, 30, 31), wherein the blade shaft can be transferred in a reversible manner from a transporting position into an operating position by virtue of being lowered relative to the housing (25, 30, 31), characterized in that the operation of lowering the blade shaft takes place entirely under gravitational force.
A system for evaluation of copy number of a nucleic acid sequence of interest in a test sample, the system comprising: a sequencer for receiving nucleic acid fragments from the test sample and providing nucleic acid sequence information of the test sample; a processor; and one or more computer-readable storage media having stored thereon instructions for execution on said processor to evaluate copy number in the test sample using the method comprising: (a) receiving sequence reads obtained by sequencing the cell-free nucleic acid fragments in the test sample; (b) aligning the sequence reads of the cell-free nucleic acid fragments to a reference genome comprising the sequence of interest, thereby providing test sequence tags, wherein the reference genome is divided into a plurality of bins; (c) determining sizes of at least some of the cell-free nucleic acid fragments in the test sample; (d) weighting the test sequence tags based on the sizes of cell-free nucleic acid fragments from which the tags are obtained; (e) calculating coverages for the bins based on the weighted tags of (d); and (f) identifying a copy number variation in the sequence of interest from the calculated coverages. a sequencer for receiving nucleic acid fragments from the test sample and providing nucleic acid sequence information of the test sample; a processor; and one or more computer-readable storage media having stored thereon instructions for execution on said processor to evaluate copy number in the test sample using the method comprising: (a) receiving sequence reads obtained by sequencing the cell-free nucleic acid fragments in the test sample; (b) aligning the sequence reads of the cell-free nucleic acid fragments to a reference genome comprising the sequence of interest, thereby providing test sequence tags, wherein the reference genome is divided into a plurality of bins; (c) determining sizes of at least some of the cell-free nucleic acid fragments in the test sample; (d) weighting the test sequence tags based on the sizes of cell-free nucleic acid fragments from which the tags are obtained; (e) calculating coverages for the bins based on the weighted tags of (d); and (f) identifying a copy number variation in the sequence of interest from the calculated coverages. (a) receiving sequence reads obtained by sequencing the cell-free nucleic acid fragments in the test sample; (b) aligning the sequence reads of the cell-free nucleic acid fragments to a reference genome comprising the sequence of interest, thereby providing test sequence tags, wherein the reference genome is divided into a plurality of bins; (c) determining sizes of at least some of the cell-free nucleic acid fragments in the test sample; (d) weighting the test sequence tags based on the sizes of cell-free nucleic acid fragments from which the tags are obtained; (e) calculating coverages for the bins based on the weighted tags of (d); and (f) identifying a copy number variation in the sequence of interest from the calculated coverages.
A system for hip fixation, comprising: a fixation element configured to be placed into a proximal femur of a subject such that a leading end of the fixation element is anchored in a head of the proximal femur and the fixation element extends from the head to a lateral portion of the proximal femur; a stop member; one or more support members (58a, 58b) configured to be connected to the proximal femur in a fixed relation to the lateral portion of the proximal femur and operatively associated with the fixation element and the stop member; wherein the system includes a deformable region (60, 222, 290) configured to plastically deform in response to a load applied to the system by the subject, such that the fixation element moves parallel to a long axis of the fixation element relative to the stop member and to the one or more support members (58a, 58b). a fixation element configured to be placed into a proximal femur of a subject such that a leading end of the fixation element is anchored in a head of the proximal femur and the fixation element extends from the head to a lateral portion of the proximal femur; a stop member; one or more support members (58a, 58b) configured to be connected to the proximal femur in a fixed relation to the lateral portion of the proximal femur and operatively associated with the fixation element and the stop member; wherein the system includes a deformable region (60, 222, 290) configured to plastically deform in response to a load applied to the system by the subject, such that the fixation element moves parallel to a long axis of the fixation element relative to the stop member and to the one or more support members (58a, 58b).
Braking element for the absorption of kinetic energy in a catch device, in particular for falling rocks, mudslides, slope-type debris flows, landslides or falling trees, comprising a base body with a first and a second fastening point, wherein at each of the first and second fastening points (14, 16) a tensile member can be arranged in such a way that a tensile force acting on the braking element between the fastening points (14, 16) can be applied by the tensile members, wherein the first and second fastening points (14, 16) are spaced apart by a distance along the tensile force, characterised in that the braking element is designed in such a way that the distance between the fastening points (14, 16) increases along a predetermined tear zone by continuous tearing and deformation of the base body when the tensile force exceeds a predetermined amount, wherein the tear zone in the base body is predetermined by a predetermined breaking point arrangement (18, 20).
A method for managing a low-latency memory including a plurality of memory banks comprising: receiving a request to store a determined number of replications of a data structure in the plurality of memory banks, wherein the request to store includes a replication factor indicative of the number of replications selected; and storing, responsive to the store request, each of the determined number of replications in a respective one of the plurality of memory banks. receiving a request to store a determined number of replications of a data structure in the plurality of memory banks, wherein the request to store includes a replication factor indicative of the number of replications selected; and storing, responsive to the store request, each of the determined number of replications in a respective one of the plurality of memory banks.
Forehead shield for a ballistic protective helmet, which is adapted to move with a visor of the protective helmet when the visor is opened and closed, characterized in that the forehead shield comprises means for removably and slidably attaching the forehead shield to the protective helmet.
A composition comprising an anti-tumor necrosis factor -alpha polypeptide, wherein the anti-TNF-alpha polypeptide is etanercept, wherein the composition is prepared by a process comprising: (a) providing a mixture comprising etanercept and impurities comprising aggregates of etanercept and misfolded forms of etanercept, (b) contacting the mixture with a hydrophobic interaction chromatography resin, such that etanercept binds to the HIC resin, and (c) eluting etanercept from the HIC resin with an elution buffer, thereby obtaining the composition comprising etanercept wherein said composition produces a reduced level of immunogenicity in the subject as compared to an ENBREL TM etanercept composition with an equivalent concentration of the etanercept, and wherein, when hydrophobic interaction high performance liquid chromatography (HI-HPLC) is performed on the composition, the composition contains a Peak 3 amount of about 12 wt.% or less. wherein the anti-TNF-alpha polypeptide is etanercept, wherein the composition is prepared by a process comprising: (a) providing a mixture comprising etanercept and impurities comprising aggregates of etanercept and misfolded forms of etanercept, (b) contacting the mixture with a hydrophobic interaction chromatography resin, such that etanercept binds to the HIC resin, and (c) eluting etanercept from the HIC resin with an elution buffer, thereby obtaining the composition comprising etanercept (a) providing a mixture comprising etanercept and impurities comprising aggregates of etanercept and misfolded forms of etanercept, (b) contacting the mixture with a hydrophobic interaction chromatography resin, such that etanercept binds to the HIC resin, and (c) eluting etanercept from the HIC resin with an elution buffer, thereby obtaining the composition comprising etanercept wherein said composition produces a reduced level of immunogenicity in the subject as compared to an ENBREL TM etanercept composition with an equivalent concentration of the etanercept, and wherein, when hydrophobic interaction high performance liquid chromatography (HI-HPLC) is performed on the composition, the composition contains a Peak 3 amount of about 12 wt.% or less.
A toilet seat hinge quick disassembly and assembly device, comprising a fixed seat and a buffer detachably connected to the fixed seat, a hinge tube, and a fixing device driving the buffer to be clamped with or separated from the fixed seat, and the fixing device comprising a locking member, a driving member driving the locking member separated from the fixed seat and a spring keeping a snap-fit of the locking member and the fixed seat, the driving member is fixedly fixed in the hinge tube circumferentially; wherein the buffer comprises a hinge body, and an outer circumference of the hinge body is provided with an accommodation groove; the driving member is rotatably arranged in the accommodation groove, the driving member is provided with a guide sliding surface, the locking member is provided with a driving portion matched with the guide sliding surface; the locking member is provided with a transverse locking portion, and one side of the transverse locking portion is provided with a clamping hole for inserting the fixed seat when assembly, an inner wall of the clamping hole is provided with a clamping portion clamped with the fixed seat; the hinge body is provided with a movable space and an accommodation hole; the transverse locking portion is slidably arranged in the movable space, and one side of the movable space facing the accommodation groove is provided with a first opening, an inner wall of the accommodation groove is provided with a second opening communicated with the accommodation hole; the other side of the transverse locking portion extends downward to form a vertical driving rod inserted in the accommodation hole after assembly; one end of the spring is against on a bottom wall of the accommodation hole; the other end of the spring is against on a side of the vertical driving rod away from the driving portion; an angle α is formed between the transverse locking portion and the vertical driving rod, and the angle α is a right angle or an inclined angle; a raised clamping rib is arranged on a periphery of the driving member, an accommodation cavity for accommodating the hinge body is arranged in the hinge tube, and a first clamping groove for inserting the clamping rib is arranged on an inner wall of the accommodation cavity; wherein a third opening communicated with the accommodation cavity is respectively arranged on both sides of the hinge tube, characterised in that a clamping fastener for fixing the buffer is provided in the third opening.
An apparatus adapted to decode network data and switch connection modes in a mobile communication, comprising: a transceiver (102, 104) configured to transmit and receive data with a network; a baseband modem coupled to the transceiver (102, 104) and configured to: connect to the network in a first mode comprising decoding data received from the network; receive a message from the network, wherein the message comprises a radio resource control, hereafter referred to as RRC, connection message; transmit a negative acknowledgement, hereafter referred to as NACK, for the message to the network; identify a retransmission of the message from the network; and switch to a second mode comprising skipping data decoding based on the identified retransmission of the message from the network and remain in the first mode if the apparatus does not receive the retransmission of the message from the network. a transceiver (102, 104) configured to transmit and receive data with a network; a baseband modem coupled to the transceiver (102, 104) and configured to: connect to the network in a first mode comprising decoding data received from the network; receive a message from the network, wherein the message comprises a radio resource control, hereafter referred to as RRC, connection message; transmit a negative acknowledgement, hereafter referred to as NACK, for the message to the network; identify a retransmission of the message from the network; and switch to a second mode comprising skipping data decoding based on the identified retransmission of the message from the network and remain in the first mode if the apparatus does not receive the retransmission of the message from the network. connect to the network in a first mode comprising decoding data received from the network; receive a message from the network, wherein the message comprises a radio resource control, hereafter referred to as RRC, connection message; transmit a negative acknowledgement, hereafter referred to as NACK, for the message to the network; identify a retransmission of the message from the network; and switch to a second mode comprising skipping data decoding based on the identified retransmission of the message from the network and remain in the first mode if the apparatus does not receive the retransmission of the message from the network.