mhurhangee/ep-ind-claims huggingface dataset:
A short turn radius steering system, comprising: a first linkage (150,250) configured to move in a first direction; a first steering assembly (110,210) comprising: a first pivot bracket (212,312) coupled to the first linkage (150,250); a first bracket linkage configured to move in a second direction and coupled to the first pivot bracket (212,312), the first bracket linkage moving linearly in the second direction responsive to rotation of the first pivot bracket caused by linear movement of the first linkage in the first direction; and a first spindle assembly coupled to the first pivot bracket (212,312) via the first bracket linkage; an axle (130,230,530), the first spindle assembly being configured to rotatably couple to the axle (130,230,530), the first pivot bracket (212,312) being configured to rotatably couple to the axle (130,230,530) at a distance to the first spindle assembly; the system further comprising: a second linkage configured to move in the first direction; a second pivot bracket coupled to the second linkage, wherein the second pivot bracket is configured to rotatably couple to the axle; a second bracket linkage configured to move in a third direction and coupled to the second pivot bracket, the second bracket linkage moving linearly in the third direction responsive to rotation of the second pivot bracket caused by linear movement of the second linkage in the first direction; and a second spindle assembly coupled to the second pivot bracket via the second bracket linkage. a first linkage (150,250) configured to move in a first direction; a first steering assembly (110,210) comprising: a first pivot bracket (212,312) coupled to the first linkage (150,250); a first pivot bracket (212,312) coupled to the first linkage (150,250); a first bracket linkage configured to move in a second direction and coupled to the first pivot bracket (212,312), the first bracket linkage moving linearly in the second direction responsive to rotation of the first pivot bracket caused by linear movement of the first linkage in the first direction; and a first spindle assembly coupled to the first pivot bracket (212,312) via the first bracket linkage; an axle (130,230,530), the first spindle assembly being configured to rotatably couple to the axle (130,230,530), the first pivot bracket (212,312) being configured to rotatably couple to the axle (130,230,530) at a distance to the first spindle assembly; the system further comprising: a second linkage configured to move in the first direction; a second linkage configured to move in the first direction; a second pivot bracket coupled to the second linkage, wherein the second pivot bracket is configured to rotatably couple to the axle; a second bracket linkage configured to move in a third direction and coupled to the second pivot bracket, the second bracket linkage moving linearly in the third direction responsive to rotation of the second pivot bracket caused by linear movement of the second linkage in the first direction; and a second spindle assembly coupled to the second pivot bracket via the second bracket linkage.
A nucleic acid construct for expressing an oxidative stress indicator comprising: a nucleic acid sequence encoding an Nrf2 protein-derived partial protein that comprises at least an Neh2 domain sequence and substantially lacks or is functionally deficient in an Neh1 domain sequence or an Neh1-Neh3 domain sequence; a stress-inducible promoter sequence that is positioned upstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein; and a nucleic acid sequence encoding a protein that is capable of generating a detectable signal, the nucleic acid sequence being positioned downstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein, wherein the Nrf2 protein-derived partial protein comprises: (i) an amino acid sequence comprising an Neh2-Neh6 domain sequence consisting of amino acids 1-433 (human) or amino acids 1-425 (mouse) in the amino acid sequence of the Nrf2 protein represented by SEQ ID NO: 1 (human) or SEQ ID NO: 2 (mouse), respectively; or (ii) an amino acid sequence having 80% or higher identity to the amino acid sequence comprising an Neh2-Neh6 domain sequence; and wherein the stress-inducible promoter sequence consists of a combination of a plurality of repeats of antioxidant responsive element and a promoter. a nucleic acid sequence encoding an Nrf2 protein-derived partial protein that comprises at least an Neh2 domain sequence and substantially lacks or is functionally deficient in an Neh1 domain sequence or an Neh1-Neh3 domain sequence; a stress-inducible promoter sequence that is positioned upstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein; and a nucleic acid sequence encoding a protein that is capable of generating a detectable signal, the nucleic acid sequence being positioned downstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein, (i) an amino acid sequence comprising an Neh2-Neh6 domain sequence consisting of amino acids 1-433 (human) or amino acids 1-425 (mouse) in the amino acid sequence of the Nrf2 protein represented by SEQ ID NO: 1 (human) or SEQ ID NO: 2 (mouse), respectively; or (ii) an amino acid sequence having 80% or higher identity to the amino acid sequence comprising an Neh2-Neh6 domain sequence; and
An engine component, adapted to be sealingly attached to an engine, wherein the engine component is provided with a seal having at least one first seal that is composed of ethylene-acrylate rubber or polyacrylate rubber and at least one second seal that is composed of fluororubber, characterized in that the engine component has a first sealing groove and second sealing groove for the first seal and the second seal, respectively, the first and the second sealing groove (32, 34) extending partially together and forming a common sealing groove in which the first and second seals (6, 8) run side by side.
A phacoemulsification system, comprising: a handpiece, wherein the handpiece comprises a needle having at least one port and wherein the needle is configured to move in a substantially longitudinal and a non-longitudinal direction; a first pump, wherein the first pump is configured to operate when a longitudinal cutting mode is selected; and a second pump, wherein the second pump is configured to operate when a non-longitudinal cutting mode is selected. a handpiece, wherein the handpiece comprises a needle having at least one port and wherein the needle is configured to move in a substantially longitudinal and a non-longitudinal direction; a first pump, wherein the first pump is configured to operate when a longitudinal cutting mode is selected; and a second pump, wherein the second pump is configured to operate when a non-longitudinal cutting mode is selected.
An apparatus for determining the proportion (h) of a conductive fluid within a mix of conductive and non-conductive fluids in a fluid-filled borehole, the apparatus comprising: one or more resistance probes for measuring the resistance of a borehole fluid with which they are in contact; a processor arranged to: a) receive resistance measurements from each of the resistance probes; and b) calculate for a measurement time period the mean (m) and standard deviation (sd) of the resistance measurements of each of the resistance probes; a transmitter arranged to transmit the calculated mean (m) and standard deviation (sd) to a receiver at a second location at the surface of the borehole; and a second processor arranged to receive, from the receiver, the mean and standard deviation, and to calculate the proportion of the conductive fluid within the mix of conductive and non-conductive fluids from the mean, the standard deviation, and an apparent resistance value (Rc,Ri) of either the conductive fluid or the non-conductive fluid. one or more resistance probes for measuring the resistance of a borehole fluid with which they are in contact; a processor arranged to: a) receive resistance measurements from each of the resistance probes; and b) calculate for a measurement time period the mean (m) and standard deviation (sd) of the resistance measurements of each of the resistance probes; a) receive resistance measurements from each of the resistance probes; and b) calculate for a measurement time period the mean (m) and standard deviation (sd) of the resistance measurements of each of the resistance probes; a transmitter arranged to transmit the calculated mean (m) and standard deviation (sd) to a receiver at a second location at the surface of the borehole; and a second processor arranged to receive, from the receiver, the mean and standard deviation, and to calculate the proportion of the conductive fluid within the mix of conductive and non-conductive fluids from the mean, the standard deviation, and an apparent resistance value (Rc,Ri) of either the conductive fluid or the non-conductive fluid.
Method for producing a bag-type kraft paper web using a paper machine comprising a forming section for forming and dewatering the paper web, a pressing section and a drying section having a pre-drying section (5.1) and a post-drying section (5.2) for further dewatering the bag-type kraft paper web, and a reel, wherein a compression device for compressing the bag-type kraft paper web is disposed between the pre-drying section (5.1) and the post-drying section (5.2), characterized in that the bag-type kraft paper web after the pre-drying section (5.1) and before the reel is imparted at least one cut in the machine running direction by at least one first cutting unit (20.1, 20.2), and is divided into at least two bag-type kraft paper partial webs (2.1, 2.2, 2.3) which lie next to one another in the cross direction, so that at least one minimum elongation value (D1min, D2min, D3min) in the cross direction of the at least two bag-type kraft paper partial webs (2.1, 2.2, 2.3) before reaching the reel is influenced by the cut in such a way that the minimum elongation value (D1min, D2min, D3min) is higher than a minimum elongation value (DOmin) of the undivided bag-type kraft paper web.
An oscillatory linear actuator comprising: an electromagnetic core block including an electromagnet; and a magnetic block that holds a permanent magnet (301, 302) so that the permanent magnet (301, 302) faces the electromagnet with a predetermined space in between, wherein the electromagnetic core block integrally includes: a core and a coil bobbin having a conductive coil wound therearound that form the electromagnet; and a base that holds the core and the coil bobbin, the magnetic block includes: the permanent magnet (301, 302); and a frame that holds the permanent magnet (301, 302) to allow the permanent magnet (301, 302) to oscillate freely and holds the electromagnetic core block, the frame has a guide portion characterized in that the guide portion is configured to guide the electromagnetic core block to adjust a positional relation of the permanent magnet (301, 302) and the electromagnet, and the base is fixed to the frame inside the guide portion. an electromagnetic core block including an electromagnet; and a magnetic block that holds a permanent magnet (301, 302) so that the permanent magnet (301, 302) faces the electromagnet with a predetermined space in between, wherein the electromagnetic core block integrally includes: a core and a coil bobbin having a conductive coil wound therearound that form the electromagnet; and a base that holds the core and the coil bobbin, a core and a coil bobbin having a conductive coil wound therearound that form the electromagnet; and a base that holds the core and the coil bobbin, the magnetic block includes: the permanent magnet (301, 302); and a frame that holds the permanent magnet (301, 302) to allow the permanent magnet (301, 302) to oscillate freely and holds the electromagnetic core block, the permanent magnet (301, 302); and a frame that holds the permanent magnet (301, 302) to allow the permanent magnet (301, 302) to oscillate freely and holds the electromagnetic core block, the frame has a guide portion the guide portion is configured to guide the electromagnetic core block to adjust a positional relation of the permanent magnet (301, 302) and the electromagnet, and the base is fixed to the frame inside the guide portion.
A detection sensor for detecting the level of a liquid in a container or a storage tank, wherein said sensor comprises a first detection device, comprising a support element adapted to be positioned, at least partially, in the inner space defined by said container intended for storing or collecting said liquid; wherein said first device comprises a first electrode and a second electrode supported by said support element in a fixed mutual position, wherein first device comprises a circuitry connected to said first electrode and said second electrode configured to establish a difference in potential or a predetermined voltage between said first electrode and said second electrode, so that an electrical resistance is established between said first electrode and said second electrode, said electrical resistance being of a predetermined value and proportionate to said predetermined difference in potential in a situation in which the level of said liquid in said container is such as not to define any conductive path between said first electrode and said second electrode, said electrical resistance being variable as soon as the level of said liquid in the container is such as to establish at least one conductive path between said first electrode and said second electrode, and wherein said circuitry is adapted to detect the variations in said electrical resistance, each of said first electrode and said second electrode being formed by a strip of electrically conductive material, having a predetermined thickness, said strip being shaped in order to define two main surfaces, which are substantially flat and opposite in the direction of said thickness, at least one of said two flat surfaces of each of said first electrode and said second electrode being placed in contact with said support element; characterized in that said first device comprises a third electrode, which is not connected to said circuitry and is thus subjected to a varying or floating electric potential, in that said third electrode is formed by a strip of electrically conductive material, having a predetermined thickness, said strip being shaped in order to define two main surfaces, which are substantially flat and opposite in the direction of said thickness, at least one of said two flat surfaces of said third electrode being placed in contact with said support element, and in that said strip of electrically conductive material of said at least one third electrode is comb-shaped and comprises a plurality of substantially rectilinear and parallel portions, joined at one end by a substantially rectilinear connection portion, which extends along a direction of extension different from the direction of extension of said substantially parallel portions, and in that said strip of electrically conductive material of said first electrode is substantially linear and placed adjacent to the linear connection portion of said strip of electrically conductive material of said third electrode.
A method for providing a tumour specific T cell preparation, comprising the steps of: a. selecting tumour-specific T cell clones by: - providing a tumour sample obtained from a patient; - isolating a nucleic acid preparation from said tumour sample in a nucleic acid isolation step; - obtaining a plurality of T cell receptor nucleic acid sequences from said nucleic acid preparation or a plurality of T cell receptor amino acid sequences encoded by said plurality of T cell receptor nucleic acid sequences; - selecting a tumour-specific T cell receptor nucleic acid sequence from said plurality of T cell receptor nucleic acid sequences or a tumour-specific T cell receptor amino acid sequence from said plurality of T cell receptor amino acid sequences in a sequence selection step; b. sorting tumour-specific T cell clones by: - providing a lymphocyte preparation obtained from said patient; - isolating cells that comprise said selected tumour-specific T cell receptor nucleic acid sequence or said selected tumour-specific T cell receptor amino acid sequence from said lymphocyte preparation in an isolation step. a. selecting tumour-specific T cell clones by: - providing a tumour sample obtained from a patient; - isolating a nucleic acid preparation from said tumour sample in a nucleic acid isolation step; - obtaining a plurality of T cell receptor nucleic acid sequences from said nucleic acid preparation or a plurality of T cell receptor amino acid sequences encoded by said plurality of T cell receptor nucleic acid sequences; - selecting a tumour-specific T cell receptor nucleic acid sequence from said plurality of T cell receptor nucleic acid sequences or a tumour-specific T cell receptor amino acid sequence from said plurality of T cell receptor amino acid sequences in a sequence selection step; - providing a tumour sample obtained from a patient; - isolating a nucleic acid preparation from said tumour sample in a nucleic acid isolation step; - obtaining a plurality of T cell receptor nucleic acid sequences from said nucleic acid preparation or a plurality of T cell receptor amino acid sequences encoded by said plurality of T cell receptor nucleic acid sequences; - selecting a tumour-specific T cell receptor nucleic acid sequence from said plurality of T cell receptor nucleic acid sequences or a tumour-specific T cell receptor amino acid sequence from said plurality of T cell receptor amino acid sequences in a sequence selection step; b. sorting tumour-specific T cell clones by: - providing a lymphocyte preparation obtained from said patient; - isolating cells that comprise said selected tumour-specific T cell receptor nucleic acid sequence or said selected tumour-specific T cell receptor amino acid sequence from said lymphocyte preparation in an isolation step. - providing a lymphocyte preparation obtained from said patient; - isolating cells that comprise said selected tumour-specific T cell receptor nucleic acid sequence or said selected tumour-specific T cell receptor amino acid sequence from said lymphocyte preparation in an isolation step.
A mycothione reductase variant consisting of an amino acid sequence represented by SEQ ID NO: 1, wherein proline, which is an amino acid corresponding to position 358 of SEQ ID NO: 3, is substituted with serine.
A servovalve comprising: a fluid transfer valve assembly comprising a supply port and a control port; a moveable valve spool arranged to regulate flow of fluid from the supply port to the control port in response to a control signal; and a drive member configured to axially move the valve spool relative to the fluid transfer valve assembly in response to the control signal to regulate the fluid flow; characterized in that the valve spool comprises a tubular member defining a through conduit for fluid from the supply port and an opening in fluid flow alignment with the supply port such that fluid can flow from the supply port into the through conduit of the tubular member and provide a balanced pressure acting on the spool; the valve spool further comprising an aperture via which fluid can flow out from the through conduit; and wherein the valve spool is axially moveable between an open position in which a fluid flow path is formed between the aperture and the control port and a closed position in which fluid is blocked from flowing between the aperture and the control port. a fluid transfer valve assembly comprising a supply port and a control port; a moveable valve spool arranged to regulate flow of fluid from the supply port to the control port in response to a control signal; and a drive member configured to axially move the valve spool relative to the fluid transfer valve assembly in response to the control signal to regulate the fluid flow; characterized in that the valve spool comprises a tubular member defining a through conduit for fluid from the supply port and an opening in fluid flow alignment with the supply port such that fluid can flow from the supply port into the through conduit of the tubular member and provide a balanced pressure acting on the spool; the valve spool further comprising an aperture via which fluid can flow out from the through conduit; and wherein the valve spool is axially moveable between an open position in which a fluid flow path is formed between the aperture and the control port and a closed position in which fluid is blocked from flowing between the aperture and the control port.
A pneumatic powered surgical stapler, comprising: a housing; an elongated member attached to the housing; a tool assembly attachable to the distal end of the elongated member, said tool assembly including an anvil assembly and a cartridge assembly each having an opposing tissue engaging surface, said cartridge assembly including a plurality of surgical fasteners; a selectively activateable drive assembly including an actuation shaft, said actuation shaft being mechanically engaged with a lead screw such that upon selective activation of said drive assembly, said actuation shaft rotates said lead screw to advance a firing shaft and actuate said tool assembly to initially clamp tissue between opposing tissue engaging surfaces of said tool assembly and subsequently to force a firing piston into said tool assembly to deform the surgical fasteners through and fasten tissue, characterized by a pressure sensitive trigger which regulates the speed of the drive assembly which, in turn, regulates the speed at which said surgical fasteners are deformed. a housing; an elongated member attached to the housing; a tool assembly attachable to the distal end of the elongated member, said tool assembly including an anvil assembly and a cartridge assembly each having an opposing tissue engaging surface, said cartridge assembly including a plurality of surgical fasteners; a selectively activateable drive assembly including an actuation shaft, said actuation shaft being mechanically engaged with a lead screw such that upon selective activation of said drive assembly, said actuation shaft rotates said lead screw to advance a firing shaft and actuate said tool assembly to initially clamp tissue between opposing tissue engaging surfaces of said tool assembly and subsequently to force a firing piston into said tool assembly to deform the surgical fasteners through and fasten tissue, characterized by a pressure sensitive trigger which regulates the speed of the drive assembly which, in turn, regulates the speed at which said surgical fasteners are deformed.