A process for manufacturing an alkylene oxide by reacting a feed gas comprising an alkylene, oxygen, and at least one organic chloride selected from the group consisting of ethyl chloride, ethylene dichloride, and vinyl chloride, over a high efficiency silver catalyst to yield a reaction product comprising the alkylene oxide, the process comprising: operating the process at an initial overall catalyst chloriding effectiveness value and an initial reaction temperature to yield an initial value of an alkylene oxide production parameter; selecting a new desired value of the alkylene oxide production parameter; and adjusting one selected from the overall catalyst chloriding effectiveness within a selected range of overall catalyst chloriding effectiveness values and the reaction temperature within a selected range of reaction temperatures, while maintaining the other of the overall catalyst chloriding effectiveness and the reaction temperature at a constant value, to yield the desired alkylene oxide production parameter; wherein the selected range of overall catalyst chloriding effectiveness Z* is from 1 to 20; wherein the selected range of reaction temperature is from 200°C to 300°C; wherein the non-chloride containing hydrocarbons in the feed gas comprise at least one selected from the group consisting of ethylene and ethane, and wherein the overall catalyst chloriding effectiveness is represented by the formula: Z * = ECL + 2 EDC + VCL ppmv C 2 H 6 + 0.01 C 2 H 4 mole percent wherein ECL is the concentration of ethyl chloride in the feed gas in ppmv, EDC is the concentration of ethylene dichloride in the feed gas in ppmv, and VCL is the concentration of vinyl chloride in the feed gas in ppmv; and wherein C 2 H 6 is the concentration of ethane in the feed gas in mole percent, and C 2 H 4 is the concentration of ethylene in the feed gas in mole percent; and wherein the alkylene oxide production parameter is selected from the group consisting of alkylene oxide concentration, alkylene oxide yield, alkylene oxide production rate, alkylene oxide production rate/catalyst volume, alkylene conversion, and oxygen conversion. operating the process at an initial overall catalyst chloriding effectiveness value and an initial reaction temperature to yield an initial value of an alkylene oxide production parameter; selecting a new desired value of the alkylene oxide production parameter; and adjusting one selected from the overall catalyst chloriding effectiveness within a selected range of overall catalyst chloriding effectiveness values and the reaction temperature within a selected range of reaction temperatures, while maintaining the other of the overall catalyst chloriding effectiveness and the reaction temperature at a constant value, to yield the desired alkylene oxide production parameter; wherein the selected range of overall catalyst chloriding effectiveness Z* is from 1 to 20; wherein the selected range of reaction temperature is from 200°C to 300°C; wherein the non-chloride containing hydrocarbons in the feed gas comprise at least one selected from the group consisting of ethylene and ethane, and wherein the overall catalyst chloriding effectiveness is represented by the formula: Z * = ECL + 2 EDC + VCL ppmv C 2 H 6 + 0.01 C 2 H 4 mole percent wherein ECL is the concentration of ethyl chloride in the feed gas in ppmv, EDC is the concentration of ethylene dichloride in the feed gas in ppmv, and VCL is the concentration of vinyl chloride in the feed gas in ppmv; and wherein C 2 H 6 is the concentration of ethane in the feed gas in mole percent, and C 2 H 4 is the concentration of ethylene in the feed gas in mole percent; and wherein the alkylene oxide production parameter is selected from the group consisting of alkylene oxide concentration, alkylene oxide yield, alkylene oxide production rate, alkylene oxide production rate/catalyst volume, alkylene conversion, and oxygen conversion.