A device for processing of a 2D X-ray image of an object, comprising: - an input unit; and - a processing unit; wherein the input unit is configured to provide shape related information from the object to be irradiated, wherein the shape related information is depth related information; and to provide a generic object model; and to provide the actual 2D X-ray image of the object; wherein the processing unit is configured to convert X-ray image data in a predetermined area of the 2D X-ray image into specific transmission values based on actually applied X-ray radiation parameters; and the processing unit is configured to determine the shape related information based on the specific transmission values, wherein the X-ray radiation parameters are settings applied for generating X-ray radiation used in acquisition of the actual 2D X-ray image, and wherein the shape related information is water equivalent thickness; wherein the processing unit is configured to segment organs in the 2D X-ray image, and wherein the organs comprises bones or lungs; wherein the processing unit is configured to adapt the generic object model based on the shape related information in order to generate an individual object model, wherein the individual object model is a 3D model of the object and after the adaptation the individual object model matches the 2D X-ray image in terms of transmission and x and y dimensions of the segmented organs; and wherein the processing unit is configured to determine, based on the individual object model, an estimation at what distance a detector was to the object in acquisition of the actual 2D X-ray image and an individual image processing modificator for processing at least one part of the 2D X-ray image; and the processing unit is configured to apply the individual image processing modificator for processing of the 2D X-ray image for feature analysis. - an input unit; and - a processing unit; wherein the input unit is configured to provide shape related information from the object to be irradiated, wherein the shape related information is depth related information; and to provide a generic object model; and to provide the actual 2D X-ray image of the object; wherein the processing unit is configured to convert X-ray image data in a predetermined area of the 2D X-ray image into specific transmission values based on actually applied X-ray radiation parameters; and the processing unit is configured to determine the shape related information based on the specific transmission values, wherein the X-ray radiation parameters are settings applied for generating X-ray radiation used in acquisition of the actual 2D X-ray image, and wherein the shape related information is water equivalent thickness; wherein the processing unit is configured to segment organs in the 2D X-ray image, and wherein the organs comprises bones or lungs; wherein the processing unit is configured to adapt the generic object model based on the shape related information in order to generate an individual object model, wherein the individual object model is a 3D model of the object and after the adaptation the individual object model matches the 2D X-ray image in terms of transmission and x and y dimensions of the segmented organs; and wherein the processing unit is configured to determine, based on the individual object model, an estimation at what distance a detector was to the object in acquisition of the actual 2D X-ray image and an individual image processing modificator for processing at least one part of the 2D X-ray image; and the processing unit is configured to apply the individual image processing modificator for processing of the 2D X-ray image for feature analysis.