A method for selectively extracting biological material from a biological sample, comprising: identifying a region of biological material to be extracted from a biological sample, the biological sample being disposed on a support substrate (28, 36, 54); applying an extraction tool (20, 30, 52) to the region of biological material to disrupt biological material from the biological sample, the extraction tool having a housing (12, 42), and at least one cutting tip (48, 57, 147) rotatably coupled to the housing and configured to be rotatably driven by a motor (56, 173), the cutting tip being operable to disrupt the biological material from the region of the biological sample; dispensing a liquid at the region of the biological material; and aspirating the liquid and the disrupted biological material from the biological sample; and characterised in that the dispensing and aspirating are performed via a separate liquid dispensing port (18, 24, 34, 45) and a separate liquid aspirating port (19, 26, 39) wherein the extraction tool further comprises the liquid dispensing port (18, 24, 34, 45) and the liquid aspirating port (19, 26, 39); wherein the liquid dispensing port is coupled to the housing and located proximal to the cutting tip, the liquid dispensing port being operable to dispense liquid at the cutting tip; wherein the liquid aspiration port is coupled to the housing and located proximal to the cutting tip, the liquid aspiration port being operable to aspirate liquid and disrupted biological material from a region proximal to the cutting tip; the extraction tool imparts a cutting motion to the region of biological material to disrupt biological material from the biological sample, wherein the cutting motion is rotating; wherein the liquid is dispensed at an interface between the region of biological material and the extraction tool (20, 30, 52), or wherein the liquid is dispensed and aspirated simultaneously. identifying a region of biological material to be extracted from a biological sample, the biological sample being disposed on a support substrate (28, 36, 54); applying an extraction tool (20, 30, 52) to the region of biological material to disrupt biological material from the biological sample, the extraction tool having a housing (12, 42), and at least one cutting tip (48, 57, 147) rotatably coupled to the housing and configured to be rotatably driven by a motor (56, 173), the cutting tip being operable to disrupt the biological material from the region of the biological sample; a housing (12, 42), and at least one cutting tip (48, 57, 147) rotatably coupled to the housing and configured to be rotatably driven by a motor (56, 173), the cutting tip being operable to disrupt the biological material from the region of the biological sample; dispensing a liquid at the region of the biological material; and aspirating the liquid and the disrupted biological material from the biological sample; and characterised in that the dispensing and aspirating are performed via a separate liquid dispensing port (18, 24, 34, 45) and a separate liquid aspirating port (19, 26, 39) wherein the extraction tool further comprises the liquid dispensing port (18, 24, 34, 45) and the liquid aspirating port (19, 26, 39); wherein the liquid dispensing port is coupled to the housing and located proximal to the cutting tip, the liquid dispensing port being operable to dispense liquid at the cutting tip; wherein the liquid aspiration port is coupled to the housing and located proximal to the cutting tip, the liquid aspiration port being operable to aspirate liquid and disrupted biological material from a region proximal to the cutting tip; the extraction tool imparts a cutting motion to the region of biological material to disrupt biological material from the biological sample, wherein the cutting motion is rotating; wherein the liquid is dispensed at an interface between the region of biological material and the extraction tool (20, 30, 52), or wherein the liquid is dispensed and aspirated simultaneously.