A compound according to Formula I or a pharmaceutically acceptable salt thereof, wherein: Z is -CH 2 O-, the CH 2 being connected to the aromatic ring containing A 4 -A 7; Y is a single carbon-carbon bond or a double carbon-carbon bond, with the proviso that when Y is a double carbon-carbon bond, R' 15 and R 16 are not present; one of the three positions A 1 -A 3 is either S or NR A, the remaining two positions A 1 -A 3 are N or CR 1, CR 2, CR 3, respectively; R A is H or methyl; R 1 -R 3 are independently H, methyl or halogen; A 4 -A 7 are N or CR 4, CR 5, CR 6 and CR 7, respectively, with the proviso that no more than two of the four positions A 4 -A 7 can be simultaneously N; A 8 -A 12 are N or CR 8, CR 9, CR 10, CR 11 and CR 12, respectively, with the proviso that no more than two of the five positions A 8 -A 12 can be simultaneously N; R 4 -R 7 are independently H, halogen, C alkyl, amino, (di)C alkylamino, C alkoxy, C alkoxyC alkoxy, -C OR 17, -C NR 17 R 17 or nitro, with all groups optionally substituted with one or more halogen or hydroxyl; R 8 -R 12 are independently H, halogen, C alkoxy, C alkyl, cyano, cyanoC alkyl, amino, nitro, aminoC alkyl, -C OR 15, -CH 2 C OR 17, -C NR 17 R 17, -NHC R 17, acetyl, hydroxyl, C cycloalkyl, C alkynyl, C alkenyl, carboxyl C alkyl, C alkylsulfonyl, aminosulfonyl, (di)C alkylamino, benzyl, SF 5 or CH(=O), with all groups optionally substituted with one or more halogen or hydroxyl; or R 9 and either R 8 or R 10 are fused and form an aromatic or non-aromatic five to seven membered ring containing two to seven carbon atoms and zero to three heteroatoms; with all groups optionally substituted with one or more methyl, halogen or hydroxyl; R 13 is H or methyl; R 14 is NH, O or S; R 15 and R' 15 are independently H, halogen, C alkyl, cyano, carboxylic acid, -C OR 17, -C NR 17 R 17; R 16 is H; and, R 17 is H, C alkyl, aminoC alkyl, C heteroaryl or phenyl, with all groups optionally substituted with one or more halogen or hydroxyl. Z is -CH 2 O-, the CH 2 being connected to the aromatic ring containing A 4 -A 7; Y is a single carbon-carbon bond or a double carbon-carbon bond, with the proviso that when Y is a double carbon-carbon bond, R' 15 and R 16 are not present; one of the three positions A 1 -A 3 is either S or NR A, the remaining two positions A 1 -A 3 are N or CR 1, CR 2, CR 3, respectively; R A is H or methyl; R 1 -R 3 are independently H, methyl or halogen; A 4 -A 7 are N or CR 4, CR 5, CR 6 and CR 7, respectively, with the proviso that no more than two of the four positions A 4 -A 7 can be simultaneously N; A 8 -A 12 are N or CR 8, CR 9, CR 10, CR 11 and CR 12, respectively, with the proviso that no more than two of the five positions A 8 -A 12 can be simultaneously N; R 4 -R 7 are independently H, halogen, C alkyl, amino, (di)C alkylamino, C alkoxy, C alkoxyC alkoxy, -C OR 17, -C NR 17 R 17 or nitro, with all groups optionally substituted with one or more halogen or hydroxyl; R 8 -R 12 are independently H, halogen, C alkoxy, C alkyl, cyano, cyanoC alkyl, amino, nitro, aminoC alkyl, -C OR 15, -CH 2 C OR 17, -C NR 17 R 17, -NHC R 17, acetyl, hydroxyl, C cycloalkyl, C alkynyl, C alkenyl, carboxyl C alkyl, C alkylsulfonyl, aminosulfonyl, (di)C alkylamino, benzyl, SF 5 or CH(=O), with all groups optionally substituted with one or more halogen or hydroxyl; or R 9 and either R 8 or R 10 are fused and form an aromatic or non-aromatic five to seven membered ring containing two to seven carbon atoms and zero to three heteroatoms; with all groups optionally substituted with one or more methyl, halogen or hydroxyl; R 13 is H or methyl; R 14 is NH, O or S; R 15 and R' 15 are independently H, halogen, C alkyl, cyano, carboxylic acid, -C OR 17, -C NR 17 R 17; R 16 is H; and, R 17 is H, C alkyl, aminoC alkyl, C heteroaryl or phenyl, with all groups optionally substituted with one or more halogen or hydroxyl.