A wearable neurostimulation system for transcutaneously stimulating peripheral nerves of a patient near or on an ear regulated by a rhythmic biological signal for a treatment of rheumatoid arthritis and inflammatory bowel disease, comprising: a first peripheral nerve effector configured to be positioned proximate a first location on a skin surface on a first ear of the patient; a second peripheral nerve effector configured to be positioned at a second location of the patient; a first biomedical sensor configured to detect activity relating to a rhythmic biological signal of the patient and convert the detected activity into a corresponding rhythmic detection signal; wherein the rhythmic biological signal comprises respiratory activity; wherein the first biomedical sensor is configured to measure a respiratory phase of the respiratory activity; a controller in operable communication with the first biomedical sensor, the controller configured to analyze the rhythmic detection signal and recognize one or more features of the rhythmic biological signal of the patient in real-time, wherein the controller is configured to generate a first electrical nerve stimulation signal to the first peripheral nerve effector to transcutaneously stimulate a first peripheral nerve upon detection of a first predetermined feature of the rhythmic biological signal, wherein the controller is configured to generate a second electrical nerve stimulation signal to the second peripheral nerve effector to transcutaneously stimulate a second peripheral nerve, wherein the stimulation of at least one of the first or second peripheral nerves is synchronized with the phase of said respiratory activity, and wherein the stimulation of the nerves treat at least one of rheumatoid arthritis and inflammatory bowel disease. a first peripheral nerve effector configured to be positioned proximate a first location on a skin surface on a first ear of the patient; a second peripheral nerve effector configured to be positioned at a second location of the patient; a first biomedical sensor configured to detect activity relating to a rhythmic biological signal of the patient and convert the detected activity into a corresponding rhythmic detection signal; wherein the rhythmic biological signal comprises respiratory activity; wherein the first biomedical sensor is configured to measure a respiratory phase of the respiratory activity; a controller in operable communication with the first biomedical sensor, the controller configured to analyze the rhythmic detection signal and recognize one or more features of the rhythmic biological signal of the patient in real-time, wherein the controller is configured to generate a first electrical nerve stimulation signal to the first peripheral nerve effector to transcutaneously stimulate a first peripheral nerve upon detection of a first predetermined feature of the rhythmic biological signal, wherein the controller is configured to generate a second electrical nerve stimulation signal to the second peripheral nerve effector to transcutaneously stimulate a second peripheral nerve, wherein the stimulation of at least one of the first or second peripheral nerves is synchronized with the phase of said respiratory activity, and wherein the stimulation of the nerves treat at least one of rheumatoid arthritis and inflammatory bowel disease.