A pneumatic tire comprising a tread portion having an asymmetric pattern having a designated installing direction to a vehicle for defining an inboard tread edge (Tei) and an outboard tread edge (Teo), and the asymmetric pattern including: an outboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the outboard tread edge (Teo); an inboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the inboard tread edge (Tei), an outboard shoulder portion between the outboard shoulder main groove and the outboard tread edge (Teo); a middle portion between the outboard shoulder main groove and the inboard shoulder main groove; and an inboard shoulder portion between the inboard shoulder main groove and the inboard tread edge (Tei), wherein the outboard shoulder portion is provided with a three dimensional sipe that has a pair of sipe surfaces extending to a depth direction of the sipe while changing its direction or opening configuration, and the inboard shoulder portion is provided with a two dimensional semi-opened sipe or the middle portion is provided with a two dimensional semi-opened or full-opened sipe, wherein said two dimensional sipe (24, 29) has a pair of sipe surfaces extending to a depth direction of the sipe (24, 29) while maintaining its direction and opening configuration. a tread portion having an asymmetric pattern having a designated installing direction to a vehicle for defining an inboard tread edge (Tei) and an outboard tread edge (Teo), and the asymmetric pattern including: an outboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the outboard tread edge (Teo); an inboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the inboard tread edge (Tei), an outboard shoulder portion between the outboard shoulder main groove and the outboard tread edge (Teo); a middle portion between the outboard shoulder main groove and the inboard shoulder main groove; and an inboard shoulder portion between the inboard shoulder main groove and the inboard tread edge (Tei), wherein the outboard shoulder portion is provided with a three dimensional sipe that has a pair of sipe surfaces extending to a depth direction of the sipe while changing its direction or opening configuration, and the inboard shoulder portion is provided with a two dimensional semi-opened sipe or the middle portion is provided with a two dimensional semi-opened or full-opened sipe, wherein said two dimensional sipe (24, 29) has a pair of sipe surfaces extending to a depth direction of the sipe (24, 29) while maintaining its direction and opening configuration. an outboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the outboard tread edge (Teo); an inboard shoulder main groove that continuously extends in a circumferential direction of the tire nearest to the inboard tread edge (Tei), an outboard shoulder portion between the outboard shoulder main groove and the outboard tread edge (Teo); a middle portion between the outboard shoulder main groove and the inboard shoulder main groove; and an inboard shoulder portion between the inboard shoulder main groove and the inboard tread edge (Tei), wherein the outboard shoulder portion is provided with a three dimensional sipe that has a pair of sipe surfaces extending to a depth direction of the sipe while changing its direction or opening configuration, and the inboard shoulder portion is provided with a two dimensional semi-opened sipe or the middle portion is provided with a two dimensional semi-opened or full-opened sipe, wherein said two dimensional sipe (24, 29) has a pair of sipe surfaces extending to a depth direction of the sipe (24, 29) while maintaining its direction and opening configuration.