A fluid handling cassette for use with a cycler of a peritoneal dialysis system, the cassette comprising: a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for fluid that include a first common channel and a second common channel; a flexible membrane attached to the first side of the body over the at least one pump chamber and a plurality of valves, a pump chamber portion of the membrane over the at least one pump chamber being arranged to be movable for movement of fluid in the pump chamber and portions of the membrane positioned over respective valves being arranged to be movable to open and close the respective valve; a patient line port arranged for connection to a patient line, the patient line port being in fluid communication with a patient line valve, which communicates with the first common channel; a plurality of solution line spikes, each of the solution line spikes being in fluid communication with a respective spike valve, each spike valve communicating with the first common channel; a drain line port arranged for connection to a drain line, the drain line port being in fluid communication with a drain line valve, which communicates with the second common channel; a heater bag line port arranged for connection to a heater bag line, the heater bag line port being in fluid communication with a heater bag valve, which communicates with the second common channel; wherein the first common channel leads to a first pump valve arranged to control flow for a first opening into the at least one pump chamber; wherein the second common channel leads to a second pump valve arranged to control for a second opening into the at least one pump chamber; wherein the heater bag line port, the patient line port and drain line port are located at a first end of the body, and the plurality of solution line spikes are located at a second end of the body. a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for fluid that include a first common channel and a second common channel; a flexible membrane attached to the first side of the body over the at least one pump chamber and a plurality of valves, a pump chamber portion of the membrane over the at least one pump chamber being arranged to be movable for movement of fluid in the pump chamber and portions of the membrane positioned over respective valves being arranged to be movable to open and close the respective valve; a patient line port arranged for connection to a patient line, the patient line port being in fluid communication with a patient line valve, which communicates with the first common channel; a plurality of solution line spikes, each of the solution line spikes being in fluid communication with a respective spike valve, each spike valve communicating with the first common channel; a drain line port arranged for connection to a drain line, the drain line port being in fluid communication with a drain line valve, which communicates with the second common channel; a heater bag line port arranged for connection to a heater bag line, the heater bag line port being in fluid communication with a heater bag valve, which communicates with the second common channel; wherein the first common channel leads to a first pump valve arranged to control flow for a first opening into the at least one pump chamber; wherein the second common channel leads to a second pump valve arranged to control for a second opening into the at least one pump chamber; wherein the heater bag line port, the patient line port and drain line port are located at a first end of the body, and the plurality of solution line spikes are located at a second end of the body.