A compound having the structure of Formula I: or a physiologically acceptable salt thereof, wherein X 1, X 2, X 3, X 4, X 5, X 6, X 7 and X 8 are independently CR 4 or N; Y 1 is hydrogen or -C(R 4) 3, each R 4 is same or different; Y 2 and Y 3 are independently hydrogen, halogen or -C(R 3) 3, each R 3 is same or different; R 1 is selected from hydrogen, halogen, C 1-6 alkyl, quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O and S, and 5 or 6 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, wherein each of quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl, and 5 or 6 membered heteroaryl can be optionally substituted with one or two, and same or different R 4; R 2 is selected from halogen, C 1-6 alkyl, quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O and S, and 5 or 6 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, wherein each of quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl, and 5 or 6 membered heteroaryl can be optionally substituted with one or two, and same or different R 4 each R 3 is independently selected from hydrogen, halogen, cyano, C 1-6 alkyl, and C 1-6 alkoxy, wherein each of the C 1-6 alkyl and C 1-6 alkoxy can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; each R 4 is independently selected from hydrogen, halogen, cyano, C 1-6 alkoxy, -S 2 R 5, -C OR 5, -C R 5, -C NR 6 R 7, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, wherein each of C 1-6 alkoxy, -S 2 R 5, -C OR 5, -C R 5, -C NR 6 R 7, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; R 5, R 6 and R 7 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, in which each of the C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; and wherein the core structure of Formula I defined by X 5, X 6, X 7 and X 8 is selected from: X 1, X 2, X 3, X 4, X 5, X 6, X 7 and X 8 are independently CR 4 or N; Y 1 is hydrogen or -C(R 4) 3, each R 4 is same or different; Y 2 and Y 3 are independently hydrogen, halogen or -C(R 3) 3, each R 3 is same or different; R 1 is selected from hydrogen, halogen, C 1-6 alkyl, quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O and S, and 5 or 6 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, wherein each of quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl, and 5 or 6 membered heteroaryl can be optionally substituted with one or two, and same or different R 4; R 2 is selected from halogen, C 1-6 alkyl, quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O and S, and 5 or 6 membered heteroaryl containing 1-4 heteroatoms selected from N, O and S, wherein each of quinolinyl, C 6-30 aryl, 3 to 6 membered heterocycloalkyl, and 5 or 6 membered heteroaryl can be optionally substituted with one or two, and same or different R 4 each R 3 is independently selected from hydrogen, halogen, cyano, C 1-6 alkyl, and C 1-6 alkoxy, wherein each of the C 1-6 alkyl and C 1-6 alkoxy can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; each R 4 is independently selected from hydrogen, halogen, cyano, C 1-6 alkoxy, -S 2 R 5, -C OR 5, -C R 5, -C NR 6 R 7, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, wherein each of C 1-6 alkoxy, -S 2 R 5, -C OR 5, -C R 5, -C NR 6 R 7, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; R 5, R 6 and R 7 are independently selected from hydrogen, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, in which each of the C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl can be optionally substituted with halo, amino, hydroxyl, C 1-6 alkoxy or cyano; and wherein the core structure of Formula I defined by X 5, X 6, X 7 and X 8 is selected from: