An angiosome-based perfusion monitoring system for peripheral artery disease, the monitoring system comprising: a compression device sized and shaped for placement on a limb of a subject, the compression device including a plurality of pressurizable bladders (15a, 15b, 15c), each bladder configured to exert a suitable compressive force on the limb of the subject when pressurized to substantially occlude blood flow into skin capillary beds adjacent to the respective pressurizable bladder, and spaced apart first and second perfusion sensors, wherein each perfusion sensor is located generally adjacent a pressurizable bladder, each of the first and second perfusion sensors configured to detect a perfusion parameter of skin capillary beds adjacent the perfusion sensor for quantifying skin capillary bed perfusion and generate a signal indicative of the perfusion parameter, wherein at least one of the first and second perfusion sensors is a first-angiosome sensor configured to detect the perfusion parameter of a skin capillary bed in a first angiosome of the limb and at least one of the first and second perfusion sensors is a second-angiosome sensor configured to detect the perfusion parameter of a skin capillary bed in a second angiosome of the limb that is different from the first angiosome, the first-angiosome sensor located generally adjacent a first bladder of the plurality of pressurizable bladders and the second-angiosome sensor located generally adjacent a second bladder of the plurality of pressurizable bladders that is different from the first bladder. a compression device sized and shaped for placement on a limb of a subject, the compression device including a plurality of pressurizable bladders (15a, 15b, 15c), each bladder configured to exert a suitable compressive force on the limb of the subject when pressurized to substantially occlude blood flow into skin capillary beds adjacent to the respective pressurizable bladder, and spaced apart first and second perfusion sensors, wherein each perfusion sensor is located generally adjacent a pressurizable bladder, each of the first and second perfusion sensors configured to detect a perfusion parameter of skin capillary beds adjacent the perfusion sensor for quantifying skin capillary bed perfusion and generate a signal indicative of the perfusion parameter, a plurality of pressurizable bladders (15a, 15b, 15c), each bladder configured to exert a suitable compressive force on the limb of the subject when pressurized to substantially occlude blood flow into skin capillary beds adjacent to the respective pressurizable bladder, and spaced apart first and second perfusion sensors, wherein each perfusion sensor is located generally adjacent a pressurizable bladder, each of the first and second perfusion sensors configured to detect a perfusion parameter of skin capillary beds adjacent the perfusion sensor for quantifying skin capillary bed perfusion and generate a signal indicative of the perfusion parameter, wherein at least one of the first and second perfusion sensors is a first-angiosome sensor configured to detect the perfusion parameter of a skin capillary bed in a first angiosome of the limb and at least one of the first and second perfusion sensors is a second-angiosome sensor configured to detect the perfusion parameter of a skin capillary bed in a second angiosome of the limb that is different from the first angiosome, the first-angiosome sensor located generally adjacent a first bladder of the plurality of pressurizable bladders and the second-angiosome sensor located generally adjacent a second bladder of the plurality of pressurizable bladders that is different from the first bladder.