A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula Ia: wherein: R 1 R 2, and R 4 are all H; R 3 is -pyridylR 14 R 15; R 6, R 7 and R 9 are independently selected from the group consisting of H, C 1-9 alkyl, halide, -CF 3, -(C 1-9 alkyl) n carbocyclyl, wherein the carbocyclyl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n heterocyclyl, wherein the heterocyclyl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n aryl, wherein the aryl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n heteroaryl, wherein the heteroaryl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, - (C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; R 10 is independently selected from the group consisting of -C 1-9 alkyl, - carbocyclyl, -aryl, and -(C 1-9 alkyl)aryl; R 11 is independently selected from the group consisting of -C 1-9 alkyl, -CF 3, - (C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; R 13 is selected from the group consisting of H, C 1-9 alkyl, halide, -CF 3, unsubstituted carbocyclyl, unsubstituted heterocyclyl, unsubstituted aryl, unsubstituted heteroaryl, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, -(C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; R 14 is -NHC(=O)R 10; R 15 is selected from H, C 1-9 alkyl, halide, -CF 3, carbocyclylR 13, heterocyclylR 13, arylR 13, heteroarylR 13, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, -(C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; Y 1, Y 2, and Y 4 are independently selected from the group consisting of carbon and nitrogen; If Y 1 is nitrogen then R 6 is absent; If Y 2 is nitrogen then R 7 is absent; If Y 4 is nitrogen then R 9 is absent; Y 3 is nitrogen and R 8 is absent; A is O; each n is 0 or 1; and wherein alkyl groups are unsubstituted and can be either saturated or unsaturated. R 1 R 2, and R 4 are all H; R 3 is -pyridylR 14 R 15; R 6, R 7 and R 9 are independently selected from the group consisting of H, C 1-9 alkyl, halide, -CF 3, -(C 1-9 alkyl) n carbocyclyl, wherein the carbocyclyl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n heterocyclyl, wherein the heterocyclyl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n aryl, wherein the aryl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n heteroaryl, wherein the heteroaryl portion is substituted by 1-5 substituents R 13, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, - (C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; R 10 is independently selected from the group consisting of -C 1-9 alkyl, - carbocyclyl, -aryl, and -(C 1-9 alkyl)aryl; R 11 is independently selected from the group consisting of -C 1-9 alkyl, -CF 3, - (C 1-9 alkyl) n carbocyclyl, -(C 1-9 alkyl) n heterocyclyl, -(C 1-9 alkyl) n aryl and -(C 1-9 alkyl) n heteroaryl; R 13 is selected from the group consisting of H, C 1-9 alkyl, halide, -CF 3, unsubstituted carbocyclyl, unsubstituted heterocyclyl, unsubstituted aryl, unsubstituted heteroaryl, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, -(C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; R 14 is -NHC(=O)R 10; R 15 is selected from H, C 1-9 alkyl, halide, -CF 3, carbocyclylR 13, heterocyclylR 13, arylR 13, heteroarylR 13, -(C 1-9 alkyl) n OR 10, -(C 1-9 alkyl) n SR 10, -(C 1-9 alkyl) n S(=O)R 11, -(C 1-9 alkyl) n SO 2 R 10, -(C 1-9 alkyl) n N(R 10)SO 2 R 10, -(C 1-9 alkyl) n SO 2 N(R 10) 2, -(C 1-9 alkyl) n N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)N(R 10) 2, -(C 1-9 alkyl) n C(=A)N(R 10) 2, -(C 1-9 alkyl) n N(R 10)C(=A)R 10, -NO 2, -CN, -(C 1-9 alkyl) n CO 2 R 10 and -(C 1-9 alkyl) n C(=A)R 10; Y 1, Y 2, and Y 4 are independently selected from the group consisting of carbon and nitrogen; If Y 1 is nitrogen then R 6 is absent; If Y 2 is nitrogen then R 7 is absent; If Y 4 is nitrogen then R 9 is absent; Y 3 is nitrogen and R 8 is absent; A is O; each n is 0 or 1; and wherein alkyl groups are unsubstituted and can be either saturated or unsaturated.