mhurhangee/ep-ind-claims huggingface dataset:
A process of manufacturing a multi-phasic, fast-dissolving dosage form for the delivery of a pharmaceutically active ingredient comprising the sequential steps of: (a) dosing a formulation comprising a non-gelling matrix forming agent into a preformed mold at a temperature ranging from 5°C to 15°C forming a non-gelled matrix layer; (b) subsequent to dosing step (a), dosing a formulation comprising a gelling matrix forming agent into the preformed mold of step (a) at a temperature ranging from 15°C to 30°C forming a gelled matrix layer; and (c) freeze drying the formulations dosed in steps (a) and (b) to form the multi-phasic, fast-dissolving dosage form, wherein step (c) comprises the sub-steps of freezing the formulations dosed in steps (a) and (b) within the preformed molds; and freeze drying the formulations dosed in steps (a) and (b). (a) dosing a formulation comprising a non-gelling matrix forming agent into a preformed mold at a temperature ranging from 5°C to 15°C forming a non-gelled matrix layer; (b) subsequent to dosing step (a), dosing a formulation comprising a gelling matrix forming agent into the preformed mold of step (a) at a temperature ranging from 15°C to 30°C forming a gelled matrix layer; and (c) freeze drying the formulations dosed in steps (a) and (b) to form the multi-phasic, fast-dissolving dosage form, wherein step (c) comprises the sub-steps of freezing the formulations dosed in steps (a) and (b) within the preformed molds; and freeze drying the formulations dosed in steps (a) and (b). freezing the formulations dosed in steps (a) and (b) within the preformed molds; and freeze drying the formulations dosed in steps (a) and (b).
A bone anchoring device including an anchoring element (1, 1'), the anchoring element comprising a shank for anchoring in bone, the shank comprising a first end and an opposite second end, and a head (3, 3'), the head having an exterior surface with a spherically-shaped section; wherein the shank and the head (3, 3') are separate parts configured to be connected to each other; and wherein the head (3, 3') comprises a first end (3a, 30a) including a drive structure (31, 31') for engagement with a drive tool, characterised in that the shank comprises an engagement portion at the first end for engaging the head and wherein the engagement portion is configured to be engaged by a drive tool; and the head comprises an opposite second end comprising a counterpart engagement portion for cooperating with the engagement portion of the shank. an anchoring element (1, 1'), the anchoring element comprising a shank for anchoring in bone, the shank comprising a first end and an opposite second end, and a head (3, 3'), the head having an exterior surface with a spherically-shaped section; wherein the shank and the head (3, 3') are separate parts configured to be connected to each other; and wherein the head (3, 3') comprises a first end (3a, 30a) including a drive structure (31, 31') for engagement with a drive tool, characterised in that the shank comprises an engagement portion at the first end for engaging the head and wherein the engagement portion is configured to be engaged by a drive tool; and the head comprises an opposite second end comprising a counterpart engagement portion for cooperating with the engagement portion of the shank.
A thin film battery package comprising: an insulating case having an internal space open at a top side thereof, and including first and second electrodes formed therein; a battery block formed by stacking a plurality of unit cells to be electrically connected to one another in the internal space, the battery block being electrically connected to the electrodes formed in the case, the battery block having a first terminal electrically connected to the first electrode and a second terminal electrically connected to the second electrode; a metal support member placed at an upper end of the case; and a cover welded to a upper side of the support member to seal the internal space, wherein each of the first and second electrodes comprises a portion which penetrates the case and extends to the exterior of the case, and wherein the internal space between the case and the cover is in a vacuum state or an inert gas-filled state. an insulating case having an internal space open at a top side thereof, and including first and second electrodes formed therein; a battery block formed by stacking a plurality of unit cells to be electrically connected to one another in the internal space, the battery block being electrically connected to the electrodes formed in the case, the battery block having a first terminal electrically connected to the first electrode and a second terminal electrically connected to the second electrode; a metal support member placed at an upper end of the case; and a cover welded to a upper side of the support member to seal the internal space,
A compound of formula: wherein: R 1 is (C 1 -C 6)alkyl; R 2 is H, (C 1 -C 15)alkyl, (C 2 -C 15)alkenyl, aryl, or heteroaryl, wherein any aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, nitro, trifluoromethyl, trifluoromethoxy, nitro, cyano, (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)cycloalkyl(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkanoyl, (C 1 -C 6)alkoxycarbonyl, and (C 2 -C 6)alkanoyloxy; R 3 is H, (C 1 -C 15)alkyl, or (C 2 -C 15)alkenyl; R 4 is H or (C 1 -C 6)alkyl; and R 5 is H or (C 1 -C 6)alkyl; or a salt thereof; provided the compound of formula is not: or R 1 is (C 1 -C 6)alkyl; R 2 is H, (C 1 -C 15)alkyl, (C 2 -C 15)alkenyl, aryl, or heteroaryl, wherein any aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, nitro, trifluoromethyl, trifluoromethoxy, nitro, cyano, (C 1 -C 6)alkyl, (C 3 -C 6)cycloalkyl, (C 3 -C 6)cycloalkyl(C 1 -C 6)alkyl, (C 1 -C 6)alkoxy, (C 1 -C 6)alkanoyl, (C 1 -C 6)alkoxycarbonyl, and (C 2 -C 6)alkanoyloxy; R 3 is H, (C 1 -C 15)alkyl, or (C 2 -C 15)alkenyl; R 4 is H or (C 1 -C 6)alkyl; and R 5 is H or (C 1 -C 6)alkyl;
A microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin, wherein, in the coating layer, the mass of arginine is 0.06 to 0.85-fold of the mass of the physiologically active substance and the mass of glycerin is 40% or less relative to the mass of the whole coating layer. a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin, the mass of arginine is 0.06 to 0.85-fold of the mass of the physiologically active substance and the mass of glycerin is 40% or less relative to the mass of the whole coating layer.
An elevator traction system, comprising: a car side wheel train; a transition wheel train; a counter-weight side wheel train; and a rope comprising a first end and a second end that are fixed to the top of a hoistway, the rope passing through the car side wheel train, the transition wheel train, and the counter-weight side wheel train sequentially, the car side wheel train comprising a first sheave and a third sheave that are fixed to the top of a car and a second sheave that is fixed to the top of the hoistway, wherein the first sheave and the third sheave are arranged to be parallel to each other and perpendicular to the second sheave; wherein a spin axis of the second sheave is arranged on a longitudinal center line of the top of the car; characterized in that the transition wheel train comprises a first transition sheave and a second transition sheave that are disposed separately at the top of the hoistway; and in that the transition wheel train further comprises a tension sheave between the first transition sheave and the second transition sheave, the tension sheave is disposed to be located in a plane the same as that of the first transition sheave and the second transition sheave, and the tension sheave is disposed to increase a wrap angle between the rope and the first transition sheave and/or second transition sheave. a car side wheel train; a transition wheel train; a counter-weight side wheel train; and a rope comprising a first end and a second end that are fixed to the top of a hoistway, the rope passing through the car side wheel train, the transition wheel train, and the counter-weight side wheel train sequentially, the car side wheel train comprising a first sheave and a third sheave that are fixed to the top of a car and a second sheave that is fixed to the top of the hoistway, wherein the first sheave and the third sheave are arranged to be parallel to each other and perpendicular to the second sheave; wherein a spin axis of the second sheave is arranged on a longitudinal center line of the top of the car; characterized in that the transition wheel train comprises a first transition sheave and a second transition sheave that are disposed separately at the top of the hoistway; and in that the transition wheel train further comprises a tension sheave between the first transition sheave and the second transition sheave, the tension sheave is disposed to be located in a plane the same as that of the first transition sheave and the second transition sheave, and the tension sheave is disposed to increase a wrap angle between the rope and the first transition sheave and/or second transition sheave.
A method of controlling the proportion of half antibody molecules in a solution, the solution comprising a population of IgG4 antibody molecules in an amount of 4 to 20 mg/ml, the method comprising: (a) contacting the solution comprising the population of IgG4 antibody molecules with a conditioned solution, wherein the conditioned solution has a pH between 3.4 to 6, and wherein the conditioned solution comprises 2-mercaptoethylamine (2-MEA) in an amount of 0.5 to 3 mM, and (b) incubating the conditioned solution comprising the IgG4 antibody molecules for a predetermined time of 0.5 to 6 h at a predetermined temperature of 8 to 22°C; wherein the incubation of the IgG4 antibody molecules with the conditioned solution decreases the proportion of half IgG4 antibody molecules. (a) contacting the solution comprising the population of IgG4 antibody molecules with a conditioned solution, wherein the conditioned solution has a pH between 3.4 to 6, and wherein the conditioned solution comprises 2-mercaptoethylamine (2-MEA) in an amount of 0.5 to 3 mM, and (b) incubating the conditioned solution comprising the IgG4 antibody molecules for a predetermined time of 0.5 to 6 h at a predetermined temperature of 8 to 22°C;
A method of filling a space between a first and a second surface to form an assembly, the method comprising the steps of: (a) providing a supply of a fluent, form-stable compound comprising an admixture of: an already cured polymer gel component which does not exhibit, except as may normally develop upon aging, further appreciable polymerization, cross-linking, vulcanization, hardening, drying, or other like chemical or physical change such as from its fluent gel form into a solid or semi-solid form or phase, a curable resin component which can undergo following dispensing further appreciable polymerization, cross-linking, vulcanization, hardening, drying, or other like chemical or physical change such as from its fluent viscous or viscoelastic form into a solid or semi-solid form or phase, and a particulate filler component, (b) dispensing an amount of the compound on to a selected one of the first and second surfaces, (c) following step (b), forming the space between the first and the second surfaces by disposing the selected one of the first and second surfaces as adjoining the other of the first and second surfaces, the space being at least partially filled by at least a portion of the compound dispensed in step (b), (d) deflecting the compound dispensed in step (b) between the first and second surfaces so as to fill the space at least partially, and (e) curing the curable resin component to form a conformable layer in the space. (a) providing a supply of a fluent, form-stable compound comprising an admixture of: an already cured polymer gel component which does not exhibit, except as may normally develop upon aging, further appreciable polymerization, cross-linking, vulcanization, hardening, drying, or other like chemical or physical change such as from its fluent gel form into a solid or semi-solid form or phase, a curable resin component which can undergo following dispensing further appreciable polymerization, cross-linking, vulcanization, hardening, drying, or other like chemical or physical change such as from its fluent viscous or viscoelastic form into a solid or semi-solid form or phase, and a particulate filler component, (b) dispensing an amount of the compound on to a selected one of the first and second surfaces, (c) following step (b), forming the space between the first and the second surfaces by disposing the selected one of the first and second surfaces as adjoining the other of the first and second surfaces, the space being at least partially filled by at least a portion of the compound dispensed in step (b), (d) deflecting the compound dispensed in step (b) between the first and second surfaces so as to fill the space at least partially, and (e) curing the curable resin component to form a conformable layer in the space.
Calibration system for the calibration of at least a distance meter, comprising: - at least one measuring section, wherein the at least one distance meter can be mounted on a first end of the measuring section, - at least a reflector which can be mounted in a moveable manner on the at least one measuring section, said reflector being designed to reflect a measuring signal (D i) emitted by the at least one distance meter, and - a laser tracker, which is arranged on an end of the measuring section situated opposite the distance meter, characterized in that a mirror arrangement is provided by means of which it is possible for the laser tracker to determine at least a distance (M i) from the at least one reflector and at least a reference distance (R i) from the at least one distance meter, and wherein a higher-level unit is provided that is designed to - determine a measured distance (X i) of the distance meter to the reflector using the distance (M i) and the reference distance (R i), and - calibrate the distance meter using the measured distance (X i) and the measuring signal (D i). - at least one measuring section, wherein the at least one distance meter can be mounted on a first end of the measuring section, - at least a reflector which can be mounted in a moveable manner on the at least one measuring section, said reflector being designed to reflect a measuring signal (D i) emitted by the at least one distance meter, and - a laser tracker, which is arranged on an end of the measuring section situated opposite the distance meter, - determine a measured distance (X i) of the distance meter to the reflector using the distance (M i) and the reference distance (R i), and - calibrate the distance meter using the measured distance (X i) and the measuring signal (D i).
An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial comprising: a body having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial; a slider axially movable along an interior of the body; and a needle assembly comprising a needle having a first tip and a second tip, the needle assembly disposed within the body and at least partially supported by a needle holder, the needle assembly movable relative to the body by the slider from an initial position in which the cartridge and the vial are engaged with the adapter assembly and the first tip and the second tip are isolated from both the cartridge and the vial, to an end of use position, in which the first tip is engaged with the vial and the second tip is engaged with the cartridge, thereby establishing fluid communication between the cartridge and the vial, wherein the needle assembly is maintained in the initial position by a locking structure (42, 62) which is released by rotating the body about the slider, thereby releasing the slider and needle holder, so that pushing the cartridge towards the vial allows the needle holder to move axially within the body. a body having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial; a slider axially movable along an interior of the body; and a needle assembly comprising a needle having a first tip and a second tip, the needle assembly disposed within the body and at least partially supported by a needle holder, the needle assembly movable relative to the body by the slider from an initial position in which the cartridge and the vial are engaged with the adapter assembly and the first tip and the second tip are isolated from both the cartridge and the vial, to an end of use position, in which the first tip is engaged with the vial and the second tip is engaged with the cartridge, thereby establishing fluid communication between the cartridge and the vial, wherein the needle assembly is maintained in the initial position by a locking structure (42, 62) which is released by rotating the body about the slider, thereby releasing the slider and needle holder, so that pushing the cartridge towards the vial allows the needle holder to move axially within the body.
A hold-open device for a fire-rated door, with a housing and with several electro-chemical energy accumulators for energy supply to the hold-open device, characterized in that the hold-open device comprises at least two accumulator groups (40, 50), wherein each accumulator group (40, 50) comprises at least one of the electro-chemical energy accumulators and an integration element (41, 51) for integrating the at least one electro-chemical energy accumulator into the rest of the hold-open device, wherein the entire lithium content of the electro-chemical energy accumulators of each accumulator group (40, 50) is less than 2 g. with a housing and with several electro-chemical energy accumulators for energy supply to the hold-open device, characterized in that the hold-open device comprises at least two accumulator groups (40, 50), wherein each accumulator group (40, 50) comprises at least one of the electro-chemical energy accumulators and an integration element (41, 51) for integrating the at least one electro-chemical energy accumulator into the rest of the hold-open device, wherein the entire lithium content of the electro-chemical energy accumulators of each accumulator group (40, 50) is less than 2 g.
An aspiration catheter system for use in thrombectomy of a thrombus, the aspiration catheter system comprising: a tubular catheter member having an open distal end and an inner diameter defining a catheter lumen; a vacuum source operably coupled to the tubular catheter member to impart a vacuum within the catheter lumen to aspirate the thrombus; a rotational drive system; and a flexible shaft operably coupled to the rotational drive system and being disposed within the catheter lumen, the rotational drive system configured to apply a rotational driving force to the flexible shaft to rotate the flexible shaft and induce rotational and orbital motion inside the catheter lumen, the flexible shaft configured to acquire a corkscrew configuration in response to the rotational driving force that results in the formation of hydrodynamic vortices within the catheter lumen. a tubular catheter member having an open distal end and an inner diameter defining a catheter lumen; a vacuum source operably coupled to the tubular catheter member to impart a vacuum within the catheter lumen to aspirate the thrombus; a rotational drive system; and a flexible shaft operably coupled to the rotational drive system and being disposed within the catheter lumen, the rotational drive system configured to apply a rotational driving force to the flexible shaft to rotate the flexible shaft and induce rotational and orbital motion inside the catheter lumen, the flexible shaft configured to acquire a corkscrew configuration in response to the rotational driving force that results in the formation of hydrodynamic vortices within the catheter lumen.
A beverage brewing process comprising the steps of: placing a desired amount of a solid beverage brewing material into a chamber; placing a desired amount of water into said chamber; sealing said chamber from the surrounding atmosphere; creating a vacuum within said chamber in the range of about -5 to about -20 inches of mercury (about 17kPa to about 68kPa); allowing said brewing material and water to brew in said chamber for a desired period of time while said vacuum is applied, removed and reapplied; maintaining the temperature of said water in the range of about 185° to about 212° F (about 85°C to about 100°C) during said brewing; removing said vacuum from said chamber, and separating said brewed liquid from said solid with the use of a filter to create said beverage. placing a desired amount of a solid beverage brewing material into a chamber; placing a desired amount of water into said chamber; sealing said chamber from the surrounding atmosphere; creating a vacuum within said chamber in the range of about -5 to about -20 inches of mercury (about 17kPa to about 68kPa); allowing said brewing material and water to brew in said chamber for a desired period of time while said vacuum is applied, removed and reapplied; maintaining the temperature of said water in the range of about 185° to about 212° F (about 85°C to about 100°C) during said brewing; removing said vacuum from said chamber, and separating said brewed liquid from said solid with the use of a filter to create said beverage.