A catheter procedure system comprising: a bedside system comprising a guide wire (58, 402), a guide wire advance/retract actuator coupled to the guide wire and a guide wire rotate actuator coupled to the guide wire; and a workstation coupled to the bedside system, the workstation comprising: a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire through a desired path of an anatomy past a junction point at a correct branch and a side branch using the guide wire advance/retract actuator; determine if a distal end of the guide wire is in the correct branch of the desired path past the junction point based at least on at least one image of a region of interest; retract the guide wire using the guide wire advance/retract actuator to a position before the junction point if the guide wire is in the side branch; automatically rotate a proximal end of the guide wire using the guide wire rotate actuator, wherein the guide wire is rotated while the guide wire is being retracted; repeat the steps of advancing the guide wire, determining if the distal end of the guide wire is in the correct branch, and retracting and automatically rotating the guide wire using guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire is in the correct branch of the desired path; and advance the guide wire to a desired position using the guide wire advance/retract actuator. a bedside system comprising a guide wire (58, 402), a guide wire advance/retract actuator coupled to the guide wire and a guide wire rotate actuator coupled to the guide wire; and a workstation coupled to the bedside system, the workstation comprising: a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire through a desired path of an anatomy past a junction point at a correct branch and a side branch using the guide wire advance/retract actuator; determine if a distal end of the guide wire is in the correct branch of the desired path past the junction point based at least on at least one image of a region of interest; retract the guide wire using the guide wire advance/retract actuator to a position before the junction point if the guide wire is in the side branch; automatically rotate a proximal end of the guide wire using the guide wire rotate actuator, wherein the guide wire is rotated while the guide wire is being retracted; repeat the steps of advancing the guide wire, determining if the distal end of the guide wire is in the correct branch, and retracting and automatically rotating the guide wire using guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire is in the correct branch of the desired path; and advance the guide wire to a desired position using the guide wire advance/retract actuator. a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire through a desired path of an anatomy past a junction point at a correct branch and a side branch using the guide wire advance/retract actuator; determine if a distal end of the guide wire is in the correct branch of the desired path past the junction point based at least on at least one image of a region of interest; retract the guide wire using the guide wire advance/retract actuator to a position before the junction point if the guide wire is in the side branch; automatically rotate a proximal end of the guide wire using the guide wire rotate actuator, wherein the guide wire is rotated while the guide wire is being retracted; repeat the steps of advancing the guide wire, determining if the distal end of the guide wire is in the correct branch, and retracting and automatically rotating the guide wire using guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire is in the correct branch of the desired path; and advance the guide wire to a desired position using the guide wire advance/retract actuator. advance the guide wire through a desired path of an anatomy past a junction point at a correct branch and a side branch using the guide wire advance/retract actuator; determine if a distal end of the guide wire is in the correct branch of the desired path past the junction point based at least on at least one image of a region of interest; retract the guide wire using the guide wire advance/retract actuator to a position before the junction point if the guide wire is in the side branch; automatically rotate a proximal end of the guide wire using the guide wire rotate actuator, wherein the guide wire is rotated while the guide wire is being retracted; repeat the steps of advancing the guide wire, determining if the distal end of the guide wire is in the correct branch, and retracting and automatically rotating the guide wire using guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire is in the correct branch of the desired path; and advance the guide wire to a desired position using the guide wire advance/retract actuator.