mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical dosage unit tablet core, the tablet core comprising: about 5 wt.% or more of a particulate pharmaceutical active drug which is cobimetinib hemifumarate polymorph Form A, wherein the particulate pharmaceutical drug active has a particle size D[v, 0.5] of from about 25 μm to about 65 μm, from about 25 μm to about 50 μm, or from about 30 μm to about 40 μm; a lubricant at a content based on the pharmaceutical dosage unit tablet core weight of from about 0.5 wt.% to about 5 wt.%, from about 0.5 wt.% to about 3 wt.%, from about 1 wt.% to about 3 wt.%, from about 1 wt.% to about 2.5 wt.%, or from about 1.5 wt.% to about 2 wt.%; a disintegrant at a content based on the pharmaceutical dosage unit tablet core weight of from about 2 wt.% to about 7 wt.%, from about 2 wt.% to about 6 wt.%, from about 2 wt.% to about 5 wt.%, from about 3 wt.% to about 6 wt.% or from about 3 wt.% to about 5 wt.%; a filler at a content based on the pharmaceutical dosage unit tablet core weight of from about 60 wt.% to about 78 wt.%, from about 65 wt.% to about 78 wt.%, from about 65 wt.% to about 77 wt.%, from about 70 wt.% to about 77 wt.%, or from about 71 wt.% to about 75 wt.%; and optionally, up to 10 wt.% of a binder; wherein the tablet core is obtainable by roller compaction of a pre-blend of the particulate pharmaceutical active drug, lubricant, disintegrant, filler, and optionally the binder by application of a compaction force of from about 1 kN/cm to about 8 kN/cm, from about 2 kN/cm to about 5 kN/cm or from about 2 kN/cm to about 4 kN/cm. about 5 wt.% or more of a particulate pharmaceutical active drug which is cobimetinib hemifumarate polymorph Form A, wherein the particulate pharmaceutical drug active has a particle size D[v, 0.5] of from about 25 μm to about 65 μm, from about 25 μm to about 50 μm, or from about 30 μm to about 40 μm; a lubricant at a content based on the pharmaceutical dosage unit tablet core weight of from about 0.5 wt.% to about 5 wt.%, from about 0.5 wt.% to about 3 wt.%, from about 1 wt.% to about 3 wt.%, from about 1 wt.% to about 2.5 wt.%, or from about 1.5 wt.% to about 2 wt.%; a disintegrant at a content based on the pharmaceutical dosage unit tablet core weight of from about 2 wt.% to about 7 wt.%, from about 2 wt.% to about 6 wt.%, from about 2 wt.% to about 5 wt.%, from about 3 wt.% to about 6 wt.% or from about 3 wt.% to about 5 wt.%; a filler at a content based on the pharmaceutical dosage unit tablet core weight of from about 60 wt.% to about 78 wt.%, from about 65 wt.% to about 78 wt.%, from about 65 wt.% to about 77 wt.%, from about 70 wt.% to about 77 wt.%, or from about 71 wt.% to about 75 wt.%; and optionally, up to 10 wt.% of a binder;
A pharmaceutical composition deliverable from a metered dose inhaler, the pharmaceutical composition comprising: a propellant of pharmaceutical grade (1 E)-1,3,3,3-Tetrafluoro-1-propene (HFO-1234ze) having a purity of at least 99.90%; a plurality of one or more species of active agent particles; and a plurality of phospholipid particles comprising perforated microstructures; wherein the one or more active agents are selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid, and a non-corticosteroid anti-inflammatory agent. a propellant of pharmaceutical grade (1 E)-1,3,3,3-Tetrafluoro-1-propene (HFO-1234ze) having a purity of at least 99.90%; a plurality of one or more species of active agent particles; and a plurality of phospholipid particles comprising perforated microstructures; wherein the one or more active agents are selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid, and a non-corticosteroid anti-inflammatory agent.
A control device of an actuator used in a condition where reaction force acting on an output shaft of the actuator increases as the output shaft is displaced in a direction in which a center axis of the output shaft extends, said actuator being adapted to convert rotary motion of a motor into linear motion of the output shaft and output the linear motion, wherein the control device detects a position of the output shaft by counting a position count value based on a pulse signal that is generated from a position sensor (S4, S5) of the actuator in accordance with rotation of the motor of the actuator, the control device comprising: rotational phase determining means for determining that the motor is in a predetermined rotational phase; number-of-revolutions determining means for, when the determination is made by the rotational phase determining means, determining the number of revolutions that have been made by the motor by the time when the determination is made by the rotational phase determining means, based on a magnitude of current applied to the motor; storage means for storing a reference count value as a reference value of the position count value, the reference count value corresponding to the predetermined rotational phase; and updating means for, when the determination is made by the rotational phase determining means, updating the position count value based on the reference count value, for each of the numbers of the revolutions that are determined by the number-of-revolutions determining means. rotational phase determining means for determining that the motor is in a predetermined rotational phase; number-of-revolutions determining means for, when the determination is made by the rotational phase determining means, determining the number of revolutions that have been made by the motor by the time when the determination is made by the rotational phase determining means, based on a magnitude of current applied to the motor; storage means for storing a reference count value as a reference value of the position count value, the reference count value corresponding to the predetermined rotational phase; and updating means for, when the determination is made by the rotational phase determining means, updating the position count value based on the reference count value, for each of the numbers of the revolutions that are determined by the number-of-revolutions determining means.
An image forming apparatus, comprising: a light source; a drum which is a photosensitive body; an optical scanning apparatus configured to deflect and scan, in a main scanning direction by a deflecting and scanning unit, a light beam emitted from the light source, and to collect, by a scanning and image forming unit, the deflected and scanned light beam onto the drum, which has a face to be scanned, to form a latent image onto a surface of the drum; and an endless belt which is arranged to be in contact with the drum and on which an image corresponding to the latent image is formed, the image forming apparatus further including a pattern forming unit configured to form, on the endless belt along a conveying direction of the endless belt, a density fluctuation detecting pattern having a period; a density sensor configured to detect the density fluctuating detecting pattern and to output a density signal including information on density fluctuations in the conveying direction of the endless belt; and a period detecting sensor configured to detect the period included in the density fluctuations, characterized by a calibrating unit configured to form, on the endless belt, a density calibrating pattern for calculating a change amount of a density relative to light amount fluctuations of the light source, wherein the calibrating unit forms the density calibrating pattern with exposure power of three or more levels that are changed by controlling exposure power of the light source and at the image area rate between 50% and 85%. a light source; a drum which is a photosensitive body; an optical scanning apparatus configured to deflect and scan, in a main scanning direction by a deflecting and scanning unit, a light beam emitted from the light source, and to collect, by a scanning and image forming unit, the deflected and scanned light beam onto the drum, which has a face to be scanned, to form a latent image onto a surface of the drum; and an endless belt which is arranged to be in contact with the drum and on which an image corresponding to the latent image is formed, the image forming apparatus further including a pattern forming unit configured to form, on the endless belt along a conveying direction of the endless belt, a density fluctuation detecting pattern having a period; a density sensor configured to detect the density fluctuating detecting pattern and to output a density signal including information on density fluctuations in the conveying direction of the endless belt; and a period detecting sensor configured to detect the period included in the density fluctuations, characterized by a calibrating unit configured to form, on the endless belt, a density calibrating pattern for calculating a change amount of a density relative to light amount fluctuations of the light source, wherein the calibrating unit forms the density calibrating pattern with exposure power of three or more levels that are changed by controlling exposure power of the light source and at the image area rate between 50% and 85%.
Method for operating, securing and/or monitoring rail-bound traffic, wherein - a signal box is controlled remotely in a first operating mode by an operation control system, characterised in that - a disruption of the signal box or a disruption of the communication between the operation control system and the signal box is established, - the operation control system is switched to a second operating mode upon establishment of the disruption and - a limited signal box functionality is provided by the operation control system in the second operating mode. - a signal box is controlled remotely in a first operating mode by an operation control system, - a disruption of the signal box or a disruption of the communication between the operation control system and the signal box is established, - the operation control system is switched to a second operating mode upon establishment of the disruption and - a limited signal box functionality is provided by the operation control system in the second operating mode.
Method for distributing fertilizer on an agricultural field by means of a spreader device which is assigned to a vehicle, wherein the spreader device is embodied as a centrifugal spreader with at least two spreader discs which are driven in rotation, wherein the fertilizer is discharged in a metered fashion respectively onto the rotating spreader disc from a reservoir container via at least one metering element, wherein during the discharging of fertilizer location data and/or position data of the vehicle is acquired, in particular, by means of a satellite navigation system and is transmitted to a computer unit which is preferably embodied as an on-board computer, wherein location and/or position data of at least one body of water (3a, 3b) is stored in the computer unit, wherein when a predefined distance (a, a1, a2) between the spreading fan of the spreader device and the body of water is reached and undershot, the mode of operation of the spreader device is subjected to open-loop or closed-loop control by the computer unit in such a way that the discharging of fertilizer is adapted and/or reduced, in order to avoid polluting the body of water (3a, 3b) with fertilizer, characterized in that when the predefined distance (a, a1, a2) from the body of water (3a, 3b) is reached and undershot discharging of the fertilizer which is adapted in respect of the spreading pattern is brought about by shifting the discharge points of the fertilizer onto the spreader disc.
Deck for forming an accessible area in a shoring tower, which can be used for fabrication or reconstruction of buildings, with a lifting lock for avoiding take off of the deck from an intended insertion position, preferably with two insertion hooks each on both front sides, wherein the lifting lock can also at a resting deck, when the deck for example remains motionless in the intended insertion position, switch from a detached position into a locked position i.e mounted on the shoring tower, only by force of gravity and the lifting lock can switch from the locked position into the detached position by lifting the deck through engaging at the lifting lock, characterized in that the lifting lock comprises a mass plate, which is translationally mounted by means of a vertical guide (6, 7), wherein the lifting lock provides a connection opening for hooking in and/or hinged hooking in of a separate lifting and holding tool, wherein the connection opening is arranged in an upper area of the mass plate.
A motorization and drive system for a pool cover, the system comprising at least one geared motor including an electric motor, a reducer, at least one output shaft, at least one flange, the output shaft being attached to the pool cover, driven in rotation by the geared motor, a fixed body housing the electric motor and the reducer, and detection means for detecting the position of the fixed body relative to a rotating element of the geared motor in order to determine the number of rotations performed by the geared motor and to determine the end positions of the pool cover, the detection means comprising magnets and a magnetic reed switch with two magnetized contacts enclosed in a capsule or plastic envelope containing nitrogen, the switch being positioned on a fixed part of the motorization system and designed to be activated by the magnets to count the number of rotations of the rotating element, with the rotating element being the output shaft to determine the end positions of the pool cover, characterized in that a plurality of magnets is positioned on the rotating element, evenly distributed around the axis of rotation of the rotating element so as to pass in front of the switch to activate it when the rotating element is driven in rotation, and in that a ring is fixed around the output shaft, the ring having a frontal wall that holds the magnets, orthogonal to the output shaft, so that the magnets are oriented coaxially to the output shaft, and in that the switch is fixed or embedded in the flange, or fixed or embedded in a fixed flange positioned around the output shaft, with the ring arranged axially between the flange and the flange.
An image processing apparatus comprising: circuitry configured to receive first image data from a first image capture device of an area adjacent to an automobile; receive second image data from a second image capture device of at least a portion of the area adjacent to the automobile; combine the first image data with the second image data to form composite image data of a junction region of the at least a portion of the area adjacent to the automobile; change over time respective boundaries of the first image data and second image data to form the composite image data of the junction region, where the boundaries at the junction region have; a strip shape having a plurality of alternating strips; and change the position of the boundaries of the plurality of strips over time. receive first image data from a first image capture device of an area adjacent to an automobile; receive second image data from a second image capture device of at least a portion of the area adjacent to the automobile; combine the first image data with the second image data to form composite image data of a junction region of the at least a portion of the area adjacent to the automobile; change over time respective boundaries of the first image data and second image data to form the composite image data of the junction region, where the boundaries at the junction region have; a strip shape having a plurality of alternating strips; and change the position of the boundaries of the plurality of strips over time.
An electric brake device comprising: a brake rotor; a brake pad; an electric motor; a linear motion mechanism configured to convert a rotary motion of the electric motor into a linear motion to transmit the linear motion to the brake pad; and a controller configured to control the electric motor, the electric brake device further comprising a vehicle speed detector configured to detect a vehicle speed, wherein: the controller includes: a motor angular velocity control section configured to control an angular velocity of the electric motor; and an angular-velocity-corresponding-to-vehicle-speed limiting section configured to limit the angular velocity of the electric motor according to the vehicle speed detected by the vehicle speed detector, and being characterized in that: the motor angular velocity control section has a PAM control section configured to perform PAM control of the electric motor, and the angular-velocity-corresponding-to-vehicle-speed limiting section provides a command to the PAM control section so as to limit an upper limit value or a lower limit value of an amplitude of an output voltage, thereby to limit the angular velocity of the electric motor in a no-load state. a motor angular velocity control section configured to control an angular velocity of the electric motor; and an angular-velocity-corresponding-to-vehicle-speed limiting section configured to limit the angular velocity of the electric motor according to the vehicle speed detected by the vehicle speed detector, and being characterized in that: the motor angular velocity control section has a PAM control section configured to perform PAM control of the electric motor, and the angular-velocity-corresponding-to-vehicle-speed limiting section provides a command to the PAM control section so as to limit an upper limit value or a lower limit value of an amplitude of an output voltage, thereby to limit the angular velocity of the electric motor in a no-load state.
An air cleaner for an internal combustion engine, the air cleaner comprising: an air cleaner case of a synthetic resin; an air cleaner element disposed in the air cleaner case and arranged to partition an inside space of the air cleaner case into a dirty side space and a clean side space, and an intake noise reducing device disposed in the air cleaner case, characterized in that the intake noise reducing device comprising, a case portion formed integrally with the air cleaner case, in a form of a tube extending from a first end opening into the inside space of the air cleaner case to a second end formed with a communication hole opening to an outside of the air cleaner case, an elastic member which is received in the case portion and which includes a bellows-shaped circumferential wall extending from a base end which is open to a forward end which is closed; a base plate covering the first end of the case portion and holding the base end of the elastic member, and a communication pipe extending through the base plate and connecting a volume chamber formed inside the elastic member to the inside space of the air cleaner case; and the air cleaner case includes a body including a rectangular open portion in which the air cleaner element is disposed, and a cover attached to the body and arranged to cover the rectangular open portion of the body, and the case portion of the intake noise reducing device is in the form of the tube extending from a bottom of the body, toward the open portion of the body, to the first end opening into the inside space of the air cleaner case. an air cleaner case of a synthetic resin; an air cleaner element disposed in the air cleaner case and arranged to partition an inside space of the air cleaner case into a dirty side space and a clean side space, and an intake noise reducing device disposed in the air cleaner case, characterized in that the intake noise reducing device comprising, a case portion formed integrally with the air cleaner case, in a form of a tube extending from a first end opening into the inside space of the air cleaner case to a second end formed with a communication hole opening to an outside of the air cleaner case, an elastic member which is received in the case portion and which includes a bellows-shaped circumferential wall extending from a base end which is open to a forward end which is closed; a base plate covering the first end of the case portion and holding the base end of the elastic member, and a communication pipe extending through the base plate and connecting a volume chamber formed inside the elastic member to the inside space of the air cleaner case; and the air cleaner case includes a body including a rectangular open portion in which the air cleaner element is disposed, and a cover attached to the body and arranged to cover the rectangular open portion of the body, and the case portion of the intake noise reducing device is in the form of the tube extending from a bottom of the body, toward the open portion of the body, to the first end opening into the inside space of the air cleaner case.
Hydraulically length-adjustable connecting rod in particular for Otto or diesel engines, which consists of two main parts made slidable on the longitudinal axis thereof relative to each other by at least one piston with associated cylinder chamber, the upper part with the small-end bearing and the lower part with the connecting rod bearing, wherein in the cylinder chamber of this piston on either side is formed at least one chamber (3, 4), characterised in that the chambers (3, 4) are connected by at least one oil supply channel (5, 5') via the crankshaft to the lubricating oil circuit of the engine, or partly connected to each other by connection of the chambers (3, 4), and the chambers (3, 4) are protected against the return of oil into the lubricating oil circuit, preferably by non-return valves (6, 6'), wherein in the connecting rod is mounted at least one bolt which is associated with the piston and in which at least one opening and/or cut-away as an exit point for the oil is formed and placed in such a way that its movement into another position allows oil to be forced out of the chamber (3, 4) which is respectively opened as a result, which can also be effected through at least one oil discharge channel associated with it, wherein the exit points for the oil from the chambers (3, 4) are oriented in such a way that the movement of the upper part of the connecting rod caused by the flowing away of oil leads to an increase in covering and then closing of the respective exit point(s) for the oil and hence the flowing away of oil is interrupted again.