mhurhangee/ep-ind-claims huggingface dataset:
A screening method for multi-target drugs and/or drug combinations, comprising the following step: step: identifying drugs and their targets from a drug target database in silico, wherein the drugs are either approved for market or under research; characterized in that it comprises the following steps after step: step: constructing target-SNP pairs by associating SNPs with genes corresponding to targets in the target-SNP pairs in silico; the targets in the target-SNP pairs being the targets identified in step; step: identifying SNP-SNP pairs by in silico screening through genome-wide association analysis, wherein SNPs in each of the SNP-SNP pairs have an interaction effect; the interaction effect being determined by an association analysis software chosen from at least one of PLINK, BOOST, or FastEpistasis; step: constructing target-target pairs by mapping the target-SNP pairs identified in step onto the SNP-SNP pairs identified in step in a computer; and step: identifying a multi-target drug and /or a drug combination by mapping the drugs identified in step onto the target-target pairs identified in step in a computer. step: identifying drugs and their targets from a drug target database in silico, wherein the drugs are either approved for market or under research; step: constructing target-SNP pairs by associating SNPs with genes corresponding to targets in the target-SNP pairs in silico; the targets in the target-SNP pairs being the targets identified in step; step: identifying SNP-SNP pairs by in silico screening through genome-wide association analysis, wherein SNPs in each of the SNP-SNP pairs have an interaction effect; the interaction effect being determined by an association analysis software chosen from at least one of PLINK, BOOST, or FastEpistasis; step: constructing target-target pairs by mapping the target-SNP pairs identified in step onto the SNP-SNP pairs identified in step in a computer; and step: identifying a multi-target drug and /or a drug combination by mapping the drugs identified in step onto the target-target pairs identified in step in a computer.
Spring for use in conjunction with a motor vehicle, in particular a leaf spring, preferably a parabolic spring, which has a one-part spring leaf made of steel, in particular spring steel, with a central region and two adjacent edge regions (4a, 4b), wherein the edge regions (4a, 4b) each have an end region (5a, 5b) and wherein end regions (5a, 5b) can each be connected to a chassis in a stationary manner via a rolled eye, wherein the total length of the spring in an installed state on the vehicle is substantially unchangeable in all load states, wherein in the unloaded state, the spring leaf has exactly two bending sections (13, 14), wherein the bending sections (13, 14) each have exactly one curvature with a curvature direction, wherein the curvature direction of the two bending sections (13, 14) is opposed and wherein the two bending sections (13, 14) merge into each other in the region of a turning point, and wherein the first bending section is a vertical spring section and runs from the end region of the first edge region via the central region to the turning point and the second bending section is a horizontal and vertical spring section and runs from the turning point to the end region of the second edge region.
A rear-focus-type lens device comprising: A mounting frame that is provided on the rear side of a lens barrel body; and an internal structure that includes a focus lens and is provided in the mounting frame, characterised in that the mounting frame includes: an inner wall that partitions the inside of the mounting frame into a first space which accommodates the internal structure and a second space which accommodates a switch assembly including a plurality of switches for operating the lens device; and an opening of the second space which is formed in the outer surface of the mounting frame and to which the switch assembly is attached, and the strength of the mounting frame is reinforced by the inner wall. A mounting frame that is provided on the rear side of a lens barrel body; and an internal structure that includes a focus lens and is provided in the mounting frame, characterised in that the mounting frame includes: an inner wall that partitions the inside of the mounting frame into a first space which accommodates the internal structure and a second space which accommodates a switch assembly including a plurality of switches for operating the lens device; and an opening of the second space which is formed in the outer surface of the mounting frame and to which the switch assembly is attached, and the strength of the mounting frame is reinforced by the inner wall. an inner wall that partitions the inside of the mounting frame into a first space which accommodates the internal structure and a second space which accommodates a switch assembly including a plurality of switches for operating the lens device; and an opening of the second space which is formed in the outer surface of the mounting frame and to which the switch assembly is attached, and the strength of the mounting frame is reinforced by the inner wall.
A staple cartridge assembly for a surgical instrument, the staple cartridge assembly comprising: a tissue thickness compensator (60120, 60920, 61020, 63020) comprising: a first compensation layer (60122a, 60922a, 61022a, 63022a); a second compensation layer (60122b, 60922b, 61022b, 63022b); and a separation gap (60132, 60932, 63032) between the first compensation layer and the second compensation layer; and a plurality of staples moveable between an initial position and a fired position, wherein each staple comprises a base and two staple legs extending from the base said staples are configured to compress at least a portion of the tissue thickness compensator to reduce the separation gap, when the staples are moved to their fired position; characterized in that the staple legs are configured to pierce said second compensation layer (60122b, 60922b, 61022b, 63022b), pass through an empty space between the first compensation layer and the second compensation layer that is formed by the separation gap (60132, 60932, 63032) and thereafter pierce said first compensation layer (60122a, 60922a, 61022a, 63022a). a tissue thickness compensator (60120, 60920, 61020, 63020) comprising: a first compensation layer (60122a, 60922a, 61022a, 63022a); a second compensation layer (60122b, 60922b, 61022b, 63022b); and a separation gap (60132, 60932, 63032) between the first compensation layer and the second compensation layer; and a first compensation layer (60122a, 60922a, 61022a, 63022a); a second compensation layer (60122b, 60922b, 61022b, 63022b); and a separation gap (60132, 60932, 63032) between the first compensation layer and the second compensation layer; and a plurality of staples moveable between an initial position and a fired position, wherein each staple comprises a base and two staple legs extending from the base said staples are configured to compress at least a portion of the tissue thickness compensator to reduce the separation gap, when the staples are moved to their fired position; characterized in that the staple legs are configured to pierce said second compensation layer (60122b, 60922b, 61022b, 63022b), pass through an empty space between the first compensation layer and the second compensation layer that is formed by the separation gap (60132, 60932, 63032) and thereafter pierce said first compensation layer (60122a, 60922a, 61022a, 63022a).
A moisture sensor comprising: a sensor probe having two spaced conductors on a probe substrate, with a probe capacitance therebetween, wherein the probe capacitance is dependent upon a moisture content proximate the two spaced conductors; a first wirelessly-interrogable SAW device having a resonance frequency that is dependent on the probe capacitance of the sensor probe; a second wirelessly-interrogable SAW device having a resonance frequency that is dependent on the probe capacitance of the sensor probe, wherein the first wirelessly-interrogable SAW device has a first propagation axis along a piezoelectric substrate, and the second wirelessly-interrogable SAW device has a second propagation axis along the piezoelectric substrate that is not parallel to the first propagation axis; and at least one antenna electrically coupled to the first wirelessly-interrogable SAW device and the second wirelessly-interrogable SAW device. a sensor probe having two spaced conductors on a probe substrate, with a probe capacitance therebetween, wherein the probe capacitance is dependent upon a moisture content proximate the two spaced conductors; a first wirelessly-interrogable SAW device having a resonance frequency that is dependent on the probe capacitance of the sensor probe; a second wirelessly-interrogable SAW device having a resonance frequency that is dependent on the probe capacitance of the sensor probe, wherein the first wirelessly-interrogable SAW device has a first propagation axis along a piezoelectric substrate, and the second wirelessly-interrogable SAW device has a second propagation axis along the piezoelectric substrate that is not parallel to the first propagation axis; and at least one antenna electrically coupled to the first wirelessly-interrogable SAW device and the second wirelessly-interrogable SAW device.
A can end structured to be affixed to a can body, the can end comprising: a severable panel having a product side structured to face toward the can body when the can end is affixed to the can body, and a public side structured to face away from the can body when the can end is affixed to the can body; a peripheral scoreline defining the periphery of the severable panel; an opening mechanism coupled to the severable panel, the opening mechanism being actuable to sever the peripheral scoreline; a rivet coupling the opening mechanism to the severable panel, the rivet having a base disposed at the severable panel and a stem extending outwardly from the severable panel; and a rivet base scoreline (121, 221) in the public side of the severable panel, the can end being characterised in that the rivet base scoreline (121, 221) includes an arcuate head portion, wherein the base of the rivet has a radius of curvature; wherein the radius of curvature forms an intersection between the stem of the rivet and the public side of the severable panel; and wherein the arcuate head portion of the rivet base scoreline (121, 221) is contiguous with the radius of curvature of the base of the rivet. a severable panel having a product side structured to face toward the can body when the can end is affixed to the can body, and a public side structured to face away from the can body when the can end is affixed to the can body; a peripheral scoreline defining the periphery of the severable panel; an opening mechanism coupled to the severable panel, the opening mechanism being actuable to sever the peripheral scoreline; a rivet coupling the opening mechanism to the severable panel, the rivet having a base disposed at the severable panel and a stem extending outwardly from the severable panel; and a rivet base scoreline (121, 221) in the public side of the severable panel, the can end being characterised in that the rivet base scoreline (121, 221) includes an arcuate head portion, wherein the base of the rivet has a radius of curvature; wherein the radius of curvature forms an intersection between the stem of the rivet and the public side of the severable panel; and wherein the arcuate head portion of the rivet base scoreline (121, 221) is contiguous with the radius of curvature of the base of the rivet.
A method of separating foreign particles, for carrying out separation of intended material particles and unintended material particles from each other from mixed powder including the intended material particles and the unintended material particles that are mixed therein and have different properties from each other, by one of electrostatic separation and magnetic separation, the method of separating foreign particles comprising the steps of: classifying the mixed powder to remove the fine powder; and imparting one of an electric charge and magnetism to the mixed powder, from which the fine powder is removed, to separate the intended material particles and the unintended material particles from each other; characterized in that said classifying step removes the fine powder having a spherical equivalent diameter of 10 μm or smaller by using a centrifugal classifier or an inertia classifier so that a content of fine powder, which has a spherical equivalent diameter of 10 μm or smaller, contained in the mixed powder is 15 mass% or less. classifying the mixed powder to remove the fine powder; and imparting one of an electric charge and magnetism to the mixed powder, from which the fine powder is removed, to separate the intended material particles and the unintended material particles from each other; characterized in that said classifying step removes the fine powder having a spherical equivalent diameter of 10 μm or smaller by using a centrifugal classifier or an inertia classifier so that a content of fine powder, which has a spherical equivalent diameter of 10 μm or smaller, contained in the mixed powder is 15 mass% or less.
A solar device comprising: a set of front device layers (602, 604, 618); a set of back device layers (616, 620); and a photoactive layer disposed between the set of front device layers and the set of back device layers, wherein at least one of the set of front device layers and the set of back device layers includes: a host material having an embedding surface; and additives at least partially embedded into the host material and localized within an embedding region adjacent to the embedding surface, wherein a thickness of the embedding region is less than an overall thickness of the host material, characterized in that said additives include a phosphor that is configured to perform spectral shifting of incident light to match an absorption of the photoactive layer. a set of front device layers (602, 604, 618); a set of back device layers (616, 620); and a photoactive layer disposed between the set of front device layers and the set of back device layers, wherein at least one of the set of front device layers and the set of back device layers includes: a host material having an embedding surface; and additives at least partially embedded into the host material and localized within an embedding region adjacent to the embedding surface, wherein a thickness of the embedding region is less than an overall thickness of the host material, a host material having an embedding surface; and additives at least partially embedded into the host material and localized within an embedding region adjacent to the embedding surface, wherein a thickness of the embedding region is less than an overall thickness of the host material, characterized in that said additives include a phosphor that is configured to perform spectral shifting of incident light to match an absorption of the photoactive layer.
A method of detecting combustor flashback in a gas turbine engine, the method comprising: positioning a dynamic pressure sensor within a combustion section having a flame tube; providing a flow of fuel to the gas turbine engine; operating the gas turbine engine to establish a flame having a flame front spaced a non-zero distance from an outlet of the flame tube; detecting pressure changes adjacent the flame tube to produce pressure signals; monitoring a characteristic of the signals provided by the dynamic pressure sensor; detecting a flashback signature within the signals provided by the dynamic pressure sensor; and varying the fuel flow in response to the detection of the flashback signature, wherein the combustion section includes a plurality of separate combustor baskets and wherein the dynamic pressure sensor is positioned to detect pressure changes within a first of the combustor baskets, wherein the flame tube is positioned within the first combustor basket, and wherein each combustor basket includes at least one flame tube, wherein the method further comprises the steps of: positioning a vibration sensor adjacent each of the plurality of combustor baskets, each vibration sensor measuring vibrations of its respective combustor basket and generating signals indicative of those measured vibrations and comparing the measured vibrations between the vibration sensors and identifying a measured vibration from one vibration sensor that is not present in the other measured vibrations. operating the gas turbine engine to establish a flame having a flame front spaced a non-zero distance from an outlet of the flame tube; detecting pressure changes adjacent the flame tube to produce pressure signals; monitoring a characteristic of the signals provided by the dynamic pressure sensor; detecting a flashback signature within the signals provided by the dynamic pressure sensor; and varying the fuel flow in response to the detection of the flashback signature, wherein the combustion section includes a plurality of separate combustor baskets and wherein the dynamic pressure sensor is positioned to detect pressure changes within a first of the combustor baskets, wherein the flame tube is positioned within the first combustor basket, and wherein each combustor basket includes at least one flame tube, wherein the method further comprises the steps of: positioning a vibration sensor adjacent each of the plurality of combustor baskets, each vibration sensor measuring vibrations of its respective combustor basket and generating signals indicative of those measured vibrations and comparing the measured vibrations between the vibration sensors and identifying a measured vibration from one vibration sensor that is not present in the other measured vibrations. positioning a vibration sensor adjacent each of the plurality of combustor baskets, each vibration sensor measuring vibrations of its respective combustor basket and generating signals indicative of those measured vibrations and comparing the measured vibrations between the vibration sensors and identifying a measured vibration from one vibration sensor that is not present in the other measured vibrations.
Method for damping vibration in a wind turbine including a plurality of aerodynamic devices for influencing the airflow flowing from the leading edge of a rotor blade of the wind turbine to the trailing edge of the rotor blade, each aerodynamic device being movable by an actuator between a first protruded configuration and a second retracted configuration, the method comprising the steps of: - measuring vibrations in the wind turbine, - if the measured vibrations are greater than a predefined threshold within a predefined frequency band, moving a portion of the aerodynamic devices to the second retracted configuration and continuing to measure vibrations in the wind turbine, - if the measured vibrations are still greater than a predefined threshold within a predefined frequency band, reducing the pitch angle interval of the rotor blade and continuing to measure vibrations in the wind turbine, - if the measured vibrations are still greater than a predefined threshold within a predefined frequency band, moving all the aerodynamic devices to the second retracted configuration. - measuring vibrations in the wind turbine, - if the measured vibrations are greater than a predefined threshold within a predefined frequency band, moving a portion of the aerodynamic devices to the second retracted configuration and continuing to measure vibrations in the wind turbine, - if the measured vibrations are still greater than a predefined threshold within a predefined frequency band, reducing the pitch angle interval of the rotor blade and continuing to measure vibrations in the wind turbine, - if the measured vibrations are still greater than a predefined threshold within a predefined frequency band, moving all the aerodynamic devices to the second retracted configuration.
Method of producing a deforming tool having a structured embossing surface, which for plastic deformation of a substrate can be brought into contact with a surface thereof, wherein the method comprises: determining a target structure to be produced on the substrate; geometrically distorting the target structure, whereby an embossing image structure is obtained; inverting the embossing image structure, whereby the embossing structure for the embossing surface is obtained; and producing the embossing surface of the deforming tool in accordance with the embossing structure. determining a target structure to be produced on the substrate; geometrically distorting the target structure, whereby an embossing image structure is obtained; inverting the embossing image structure, whereby the embossing structure for the embossing surface is obtained; and producing the embossing surface of the deforming tool in accordance with the embossing structure.
Hydraulic unit for supplying pressure to a hydraulic steering system having at least two hydraulic cylinders (2a, 2b, 27a, 27b) and at least one hydraulic pump (9, 10, 32, 33), wherein the hydraulic cylinders (2a, 2b, 27a, 27b) are configured to co-operate as differential cylinders, this being effected by an annular chamber (6a, 6b, 28a, 28b) of the first hydraulic cylinder (2a, 2b, 27a, 27b) being connected via at least one hydraulic line to an annular chamber (6a, 6b, 28a, 28b) of the second hydraulic cylinder (2a, 2b, 27a, 27b) and by a piston chamber (5a, 5b, 29a, 29b) of the first hydraulic cylinder (2a, 2b, 27a, 27b) being connected via at least one hydraulic line to a piston chamber (5a, 5b, 29a, 29b) of the second hydraulic cylinder (2a, 2b, 27a, 27b) and by a hydraulic pump (9, 10, 32, 33) being arranged at least in a hydraulic line (7, 8, 30, 31) between the two annular chambers (6a, 6b, 28a, 28b) or in a hydraulic line between the two piston chambers (5a, 5b, 29a, 29b), characterised in that the hydraulic unit comprises at least one second hydraulic pump (9, 10, 32, 33), a hydraulic pump (9, 10, 32, 33) being arranged in the hydraulic line (7, 8, 30, 31) between the two annular chambers (6a, 6b, 28a, 28b) and a hydraulic pump (9, 10, 32, 33) being arranged in the hydraulic line (7, 8, 30, 31) between the two piston chambers (5a, 5b, 29a, 29b). the hydraulic cylinders (2a, 2b, 27a, 27b) are configured to co-operate as differential cylinders, this being effected by an annular chamber (6a, 6b, 28a, 28b) of the first hydraulic cylinder (2a, 2b, 27a, 27b) being connected via at least one hydraulic line to an annular chamber (6a, 6b, 28a, 28b) of the second hydraulic cylinder (2a, 2b, 27a, 27b) and by a piston chamber (5a, 5b, 29a, 29b) of the first hydraulic cylinder (2a, 2b, 27a, 27b) being connected via at least one hydraulic line to a piston chamber (5a, 5b, 29a, 29b) of the second hydraulic cylinder (2a, 2b, 27a, 27b) and by a hydraulic pump (9, 10, 32, 33) being arranged at least in a hydraulic line (7, 8, 30, 31) between the two annular chambers (6a, 6b, 28a, 28b) or in a hydraulic line between the two piston chambers (5a, 5b, 29a, 29b), characterised in that the hydraulic unit comprises at least one second hydraulic pump (9, 10, 32, 33), a hydraulic pump (9, 10, 32, 33) being arranged in the hydraulic line (7, 8, 30, 31) between the two annular chambers (6a, 6b, 28a, 28b) and a hydraulic pump (9, 10, 32, 33) being arranged in the hydraulic line (7, 8, 30, 31) between the two piston chambers (5a, 5b, 29a, 29b).