A machine to manufacture components made of wood or the like starting from a flat panel delimited by a first side face, which is parallel to a first direction, and by a pair of second side faces (4, 4*), which are opposite one another and parallel to a second direction perpendicular to the first direction, the machine comprising support means (8, 9, 10) defining a support surface for the panel; a first holding device, which is designed to hold the panel in the area of a second side face; and at least one operating head (33; 38) to process the panel; wherein the first holding device and the operating head (33; 38) are movable relative to one another at least in the first direction, so as to allow the operating head (33; 38) to separate at least one component from the panel; wherein a second holding device, is designed to hold the panel in the area of the other second side face (4, 4*), characterized in that each one of said first and second holding devices (25, 28) comprises at least one clamping member provided with two jaws (26, 27, 29, 30), which are movable between a clamping position and a release position to clamp and release the panel, wherein the first holding device and the second holding device comprise at least one clamping member comprising, in turn, a lower jaw (26, 29) and an upper jaw (27, 30), which are movable between a clamping position and a release position to clamp and release the panel; wherein the support means having a plurality of feeding channels, which extend in the first direction, open up towards the outside in the area of the support surface and are engaged by the lower jaws (26,29) of the respective clamping members in a sliding manner, wherein said machine is such that the support means further have a cutting channel, which extends in the second direction and through said further feeding channels, and is engaged by a tool (35; 40) of at least one operating head (33; 38). wherein the first holding device and the operating head (33; 38) are movable relative to one another at least in the first direction, so as to allow the operating head (33; 38) to separate at least one component from the panel; wherein a second holding device, is designed to hold the panel in the area of the other second side face (4, 4*), characterized in that each one of said first and second holding devices (25, 28) comprises at least one clamping member provided with two jaws (26, 27, 29, 30), which are movable between a clamping position and a release position to clamp and release the panel, wherein the first holding device and the second holding device comprise at least one clamping member comprising, in turn, a lower jaw (26, 29) and an upper jaw (27, 30), which are movable between a clamping position and a release position to clamp and release the panel; wherein the support means having a plurality of feeding channels, which extend in the first direction, open up towards the outside in the area of the support surface and are engaged by the lower jaws (26,29) of the respective clamping members in a sliding manner, wherein said machine is such that the support means further have a cutting channel, which extends in the second direction and through said further feeding channels, and is engaged by a tool (35; 40) of at least one operating head (33; 38).