New differential release pharmaceutical composition in the form of pellets or microspheres comprising: - losartan potassium in amount of 5% to 20% by weight of the composition; - amlodipine in amount of 0.5% to 3% by weight of the composition; - hydrochlorothiazide in amount of 1% to 4% by weight of the composition; - sugar-starch spheres carrier or substrate in amount of 55% to 65% by weight of composition; and - a first coating in amount of 2% to 4% by weight of the composition, wherein the first coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising hydrochlorothiazide; - a second coating in amount of 7% to 9% by weight of the composition, wherein the second coating is an extended release coating that it forms a film, having plasticizer and stabilizer characteristics and it has a primary composition consisting of, expressed as % of the total weight, 60% to 62% ethyl cellulose, 17% oleic acid, 14% to 16% ammonium hydroxide and 6% to 7% hydroxypropyl cellulose; a secondary composition that is the composition of the first coating; and wherein the weight ratio of the primary composition to the second is 9:1; - a third coating in amount of 2% to 4% by weight of the composition, wherein the third coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising amlodipine besylate; - a fourth coating in amount of 4% to 6% by weight of the composition, wherein the fourth coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising losartan potassium; and - a fifth coating in amount of 6% to 8% by weight of the composition, wherein the fifth coating is an immediate dissolution water soluble layer that its composition, expressed as % of the total weight, comprises 40% polyvinyl alcohol; 20% to 22% polyethylene glycol; 18% to 20% titanium dioxide; 14% to 16% talc, and 5% to 7% of a pharmaceutically acceptable pigment - losartan potassium in amount of 5% to 20% by weight of the composition; - amlodipine in amount of 0.5% to 3% by weight of the composition; - hydrochlorothiazide in amount of 1% to 4% by weight of the composition; - sugar-starch spheres carrier or substrate in amount of 55% to 65% by weight of composition; and - a first coating in amount of 2% to 4% by weight of the composition, wherein the first coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising hydrochlorothiazide; - a second coating in amount of 7% to 9% by weight of the composition, wherein the second coating is an extended release coating that it forms a film, having plasticizer and stabilizer characteristics and it has a primary composition consisting of, expressed as % of the total weight, 60% to 62% ethyl cellulose, 17% oleic acid, 14% to 16% ammonium hydroxide and 6% to 7% hydroxypropyl cellulose; a secondary composition that is the composition of the first coating; and wherein the weight ratio of the primary composition to the second is 9:1; - a third coating in amount of 2% to 4% by weight of the composition, wherein the third coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising amlodipine besylate; - a fourth coating in amount of 4% to 6% by weight of the composition, wherein the fourth coating is an immediate release coating that it is water soluble regardless of the pH and its composition is, expressed as % of the total weight, 52% to 55% polyvinyl alcohol; 30% talc; between 14% and 16% polyethylene glycol and 3% polysorbate 80; and comprising losartan potassium; and - a fifth coating in amount of 6% to 8% by weight of the composition, wherein the fifth coating is an immediate dissolution water soluble layer that its composition, expressed as % of the total weight, comprises 40% polyvinyl alcohol; 20% to 22% polyethylene glycol; 18% to 20% titanium dioxide; 14% to 16% talc, and 5% to 7% of a pharmaceutically acceptable pigment