mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula: wherein X is O, NR 6, or S; R 1 is C 1 -C 6 alkyl; R 2 is phenyl, or heteroaryl, wherein the heteroaryl moiety is a 5- or 6-membered aromatic ring which comprises 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, and wherein each phenyl and heteroaryl moiety may be optionally substituted with 1, 2, 3, or 4 groups, which may be the same or different, represented by R 7; R 3 is hydrogen, C 1 -C 6 alkyl, N,N-di(C 1 -C 3 alkyl)amino, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkylC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, phenyl, or phenylC 1 -C 3 alkyl, wherein the phenyl moieties may be optionally substituted with 1, 2, 3 or 4 groups, which may be the same or different, represented by R 8; R 4 is cyano, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxyC 2 -C 6 alkenyl, C 2 -C 6 alkenyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, or hydroxycarbonyl; R 5 is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, or C 1 -C 4 alkoxyC 1 -C 4 alkyl; R 6 is hydrogen, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; R 7 is halogen, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; R 8 is halogen, cyano, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; or a salt or an N-oxide thereof. X is O, NR 6, or S; R 1 is C 1 -C 6 alkyl; R 2 is phenyl, or heteroaryl, wherein the heteroaryl moiety is a 5- or 6-membered aromatic ring which comprises 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, and wherein each phenyl and heteroaryl moiety may be optionally substituted with 1, 2, 3, or 4 groups, which may be the same or different, represented by R 7; R 3 is hydrogen, C 1 -C 6 alkyl, N,N-di(C 1 -C 3 alkyl)amino, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkylC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, phenyl, or phenylC 1 -C 3 alkyl, wherein the phenyl moieties may be optionally substituted with 1, 2, 3 or 4 groups, which may be the same or different, represented by R 8; R 4 is cyano, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxyC 2 -C 6 alkenyl, C 2 -C 6 alkenyloxyC 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, or hydroxycarbonyl; R 5 is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, or C 1 -C 4 alkoxyC 1 -C 4 alkyl; R 6 is hydrogen, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; R 7 is halogen, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; R 8 is halogen, cyano, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy; or a salt or an N-oxide thereof.
A compound of the general formula: in which X represents a polymer; Q represents a direct bond or an alkylene group, either of which may be terminated or interrupted by one or more oxygen atoms, sulphur atoms, -NR- groups (in which R represents a hydrogen atom or an alkyl or an aryl group), keto groups, -O-CO- groups and/or -CO-O- groups; W represents a keto group CO, an ester group -O-CO-, an amide group -NH-CO-, or a sulphone group -SO 2 -, or a moiety preparable by reduction of such a group; each of R 1 and R 2 independently represents a hydrogen atom or a C 1-4 alkyl group; and Z represents a protein or peptide. in which X represents a polymer; Q represents a direct bond or an alkylene group, either of which may be terminated or interrupted by one or more oxygen atoms, sulphur atoms, -NR- groups (in which R represents a hydrogen atom or an alkyl or an aryl group), keto groups, -O-CO- groups and/or -CO-O- groups; W represents a keto group CO, an ester group -O-CO-, an amide group -NH-CO-, or a sulphone group -SO 2 -, or a moiety preparable by reduction of such a group; each of R 1 and R 2 independently represents a hydrogen atom or a C 1-4 alkyl group; and Z represents a protein or peptide.
A compound of formula: or a tautomeric or a stereochemically isomeric form, a pharmaceutically acceptable salt or a solvate thereof, wherein: R 1, R 2, R 3 and R 4 independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, halogen, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 3-8 cycloalkyl, cyano or -NR x R y; R 5 represents hydrogen or C 1-6 alkyl; n represents an integer selected from 0, 1, 2 or 3; R 6 represents halogen or C 1-6 alkyl; X represents a C 1 -C 4 alkylene group optionally substituted by an O, OH or CONR 8 group; R 8 represents hydrogen or C 1-6 alkyl; R 7 represents a -Het A -CO-CH=CHR 9 or -Het B -Y-Het C -CO-CH=CHR 9 group; Y represents a bond or -O-; R 9 represents hydrogen, -CH 2 -NR x R y or -Het D; Het A, Het B, Het C and Het D each represent a heterocyclyl or a heteroaryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents such as C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, -COO-C 2-6 alkynyl, -CO-C 1-6 alkyl, hydroxy and oxo; and R x and R y independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or R x and R y together with the nitrogen atom to which they are attached join to form a nitrogen containing heterocyclic ring which may be optionally substituted by one or more C 1-6 alkyl groups. R 1, R 2, R 3 and R 4 independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, halogen, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 3-8 cycloalkyl, cyano or -NR x R y; R 5 represents hydrogen or C 1-6 alkyl; n represents an integer selected from 0, 1, 2 or 3; R 6 represents halogen or C 1-6 alkyl; X represents a C 1 -C 4 alkylene group optionally substituted by an O, OH or CONR 8 group; R 8 represents hydrogen or C 1-6 alkyl; R 7 represents a -Het A -CO-CH=CHR 9 or -Het B -Y-Het C -CO-CH=CHR 9 group; Y represents a bond or -O-; R 9 represents hydrogen, -CH 2 -NR x R y or -Het D; Het A, Het B, Het C and Het D each represent a heterocyclyl or a heteroaryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents such as C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, -COO-C 2-6 alkynyl, -CO-C 1-6 alkyl, hydroxy and oxo; and R x and R y independently represent hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or R x and R y together with the nitrogen atom to which they are attached join to form a nitrogen containing heterocyclic ring which may be optionally substituted by one or more C 1-6 alkyl groups.
A method for use in a sensor calibration system, the method comprising: using a magnetic field sensor (34, 71) mounted on a second sensor to measure a received magnetic field generated by a magnetic field transmitter (22, 44, 51), the magnetic field sensor (34, 71) being part of a sensor calibration system for calibrating output of the second sensor; computing, using at least one processor, a position, an orientation or a displacement of the second sensor based on an output of the magnetic field sensor (34, 71); determining, using the at least one processor, a parameter based on an output of the magnetic field sensor (34, 71) that represents or that is a function of a distance between the magnetic field sensor (34, 71) and the magnetic field transmitter (22, 44, 51) of the sensor calibration system; and characterised by dynamically adjusting, using the at least one processor, a receiver bandwidth of the magnetic field sensor (34, 71) during operation of the magnetic field sensor (34, 71) based on the parameter; wherein the parameter comprises magnetic field strength or signal-to-noise ratio. using a magnetic field sensor (34, 71) mounted on a second sensor to measure a received magnetic field generated by a magnetic field transmitter (22, 44, 51), the magnetic field sensor (34, 71) being part of a sensor calibration system for calibrating output of the second sensor; computing, using at least one processor, a position, an orientation or a displacement of the second sensor based on an output of the magnetic field sensor (34, 71); determining, using the at least one processor, a parameter based on an output of the magnetic field sensor (34, 71) that represents or that is a function of a distance between the magnetic field sensor (34, 71) and the magnetic field transmitter (22, 44, 51) of the sensor calibration system; and characterised by dynamically adjusting, using the at least one processor, a receiver bandwidth of the magnetic field sensor (34, 71) during operation of the magnetic field sensor (34, 71) based on the parameter; wherein the parameter comprises magnetic field strength or signal-to-noise ratio.
A process for the synthesis of a scale inhibitor of Formula I wherein: M, M' and M" are independently selected from hydrogen and/or cation, and R is selected from C 2 -C 15 linear, branched alkyl moiety, such alkyl moiety being optionally substituted by a C 1 -C 6 linear, branched or cyclic alkyl group; comprising the steps of reacting a non-formyl lactam, selected from C 3 -C 16 lactams optionally substituted by C 1 -C 6 linear, branched or cyclic alkyl group, with formic acid, at temperature above 100 °C and for a time comprised in the range of 0.5 to 5 hours obtaining thereby a correspondent N-formyl lactam and subsequently reacting a solution of a dehydrated phosphorous acid with the obtained N-formyl lactam, thereby providing said scale inhibitor of Formula I. wherein: M, M' and M" are independently selected from hydrogen and/or cation, and R is selected from C 2 -C 15 linear, branched alkyl moiety, such alkyl moiety being optionally substituted by a C 1 -C 6 linear, branched or cyclic alkyl group; comprising the steps of reacting a non-formyl lactam, selected from C 3 -C 16 lactams optionally substituted by C 1 -C 6 linear, branched or cyclic alkyl group, with formic acid, at temperature above 100 °C and for a time comprised in the range of 0.5 to 5 hours obtaining thereby a correspondent N-formyl lactam and subsequently reacting a solution of a dehydrated phosphorous acid with the obtained N-formyl lactam, thereby providing said scale inhibitor of Formula I.
An eddy current rail brake which is adapted to be mounted on a bogie frame of a railway car and which has a magnet unit which is adapted to generate a magnetic attraction force with respect to a rail, the magnet unit comprises an elongated support member and a plurality of permanent magnets, the support member is ferromagnetic and is installed such that when the rail brake is mounted on the bogie frame, the support member extends in a direction generally parallel to the direction in which a side beam of the bogie frame extends, characterized in that: it can rotate about an axis which is generally parallel to the direction in which the side beam extends, the plurality of permanent magnets are installed on the support member in series in said generally parallel direction with their pole faces spaced above the rail, and of the plurality of permanent magnets, at least two adjoining permanent magnets are arranged so as to have different polarities from each other.
A method for separating and recovering a radioisotope from an aqueous solution comprising the radioisotope, the method comprising using a microfluidic device comprising a chamber: flowing the aqueous solution to the chamber, the chamber comprises a first electrode and a second electrode; generating a first electric field between the first and second electrodes, thereby trapping the radioisotope on the first electrode; flowing an organic-based solution to the chamber comprising the first and the second electrodes; and generating a second electric field between the first and the second electrodes, wherein the second electric field has an opposing polarity to the first electric field, thereby releasing the radioactive isotope from the first electrode into the organic based solution, wherein the first electrode is formed from a carbon rod or section thereof and has a flat surface comprising a plurality of recesses. flowing the aqueous solution to the chamber, the chamber comprises a first electrode and a second electrode; generating a first electric field between the first and second electrodes, thereby trapping the radioisotope on the first electrode; flowing an organic-based solution to the chamber comprising the first and the second electrodes; and generating a second electric field between the first and the second electrodes, wherein the second electric field has an opposing polarity to the first electric field, thereby releasing the radioactive isotope from the first electrode into the organic based solution, wherein the first electrode is formed from a carbon rod or section thereof and has a flat surface comprising a plurality of recesses.
A process of making a fiber optic for conducting light from a laser to the terminal end of the fiber optic for the purpose of treating tissues in surgery, the process comprising: providing a polymer clad, silica core fiber, stripping cladding from a terminal end of the polymer clad, silica core fiber, and fusing a short section of fluorine-doped tubing about the stripped terminal end of the polymer clad, silica core fiber, thereby forming a fiber at the terminal end with a higher CCDR than the polymer clad, silica core fiber, where a reflective bevel is polished on a terminal end of the fused section for the purpose of redirecting light laterally out of the terminal end of the fiber optic with respect to the fiber axis.
A spray gun for mixing and atomizing a coating material flow and the air flow in the atmosphere, the spray gun comprising: a body having a gun barrel, a coating material nozzle disposed on a tip end side of the gun barrel, ejecting the coating material flow from a coating material ejection opening formed on a tip end surface of the coating material nozzle; and an air cap disposed on the tip end side of the gun barrel to surround a tip end portion of the coating material nozzle, the air cap defining a ring-shaped slit between an inner peripheral surface of the air cap and an outer peripheral surface of the tip end portion of the coating material nozzle to allow the air flow to be ejected through the slit, wherein the tip end portion of the coating material nozzle has on the tip end surface thereof a guide wall spreading from an internal periphery of the coating material ejection opening toward a tip end side of the coating material nozzle, the guide wall controlling the coating material flow ejected from the coating material ejection opening, and also has on the outer peripheral surface of the tip end portion a plurality of air grooves in a V shape channeled in a longitudinal direction from a predetermined position (r) on a rear end side of the tip end portion to the guide wall, the air grooves inducing a part of the air flow ahead of the coating material ejection opening, wherein each of the air grooves has a bottom portion (b) gradually increasing in depth in the longitudinal direction, characterized in that the bottom portion (b) having a curvature radius R of 0.15 mm or less. a body having a gun barrel, a coating material nozzle disposed on a tip end side of the gun barrel, ejecting the coating material flow from a coating material ejection opening formed on a tip end surface of the coating material nozzle; and an air cap disposed on the tip end side of the gun barrel to surround a tip end portion of the coating material nozzle, the air cap defining a ring-shaped slit between an inner peripheral surface of the air cap and an outer peripheral surface of the tip end portion of the coating material nozzle to allow the air flow to be ejected through the slit, wherein the tip end portion of the coating material nozzle has on the tip end surface thereof a guide wall spreading from an internal periphery of the coating material ejection opening toward a tip end side of the coating material nozzle, the guide wall controlling the coating material flow ejected from the coating material ejection opening, and also has on the outer peripheral surface of the tip end portion a plurality of air grooves in a V shape channeled in a longitudinal direction from a predetermined position (r) on a rear end side of the tip end portion to the guide wall, the air grooves inducing a part of the air flow ahead of the coating material ejection opening, wherein each of the air grooves has a bottom portion (b) gradually increasing in depth in the longitudinal direction, characterized in that the bottom portion (b) having a curvature radius R of 0.15 mm or less.
Method for rating the behaviour of the driver in a vehicle, in which sensor data are ascertained and the driver behaviour is rated on the basis of the sensor data, characterized in that an ambient sensor system is used to evaluate the distance from a third-party vehicle or from lateral road boundaries and a distinction is drawn between different behaviour categories and each behaviour category is assigned the sensor data with a probability, wherein a behaviour category is identified as applicable if the assigned probability exceeds a threshold value.
A process for the preparation of a carbapenem, said process comprising the step of treating a solution of a protected carbapenem, wherein the protected carbapenem comprises one or more protecting groups selected from the group consisting of unsubstituted benzyl, substituted benzyl, unsubstituted -carboxybenzyl, substituted -carboxybenzyl groups, and a combination thereof, with hydrogen gas in the presence of a heterogeneous catalyst to form the carbapenem, wherein the heterogeneous catalyst is a mixed metal catalyst and comprises at least two platinum group metals, wherein the wt% ratio of one PGM to the other PGM may be in the range of 10: 0.01 to 0.01: 10.
An oligonucleotide comprising the sequence of formula III: 5'-dA*+T*dG*+G*dC*+T*dG*+T*dA*+G*dA*dC*dT*dG*+T*+T-3' wherein dA is 2'deoxyadenosine, dG is 2'deoxyguanosine, dC is 2'deoxycytidine and T is thymidine, wherein +T is an LNA-T building block and +G is an LNA-G building block and wherein * is a phosphorothioate linkage, for use in the prevention or treatment of a cardiac disorder in a human subject, wherein the cardiac disorder is selected from (i) acute or subacute heart failure, (ii) chronic and/or worsening chronic heart failure, (iii) stable heart failure, (iv) a less advanced state of heart failure or from an advanced state of heart failure, (v) heart failure of NYHA stage I and/or II, NYHA stage I, II and/or III or of NYHA stage III and/or IV, and (vi) right-sided heart failure. wherein dA is 2'deoxyadenosine, dG is 2'deoxyguanosine, dC is 2'deoxycytidine and T is thymidine, wherein +T is an LNA-T building block and +G is an LNA-G building block and wherein * is a phosphorothioate linkage, for use in the prevention or treatment of a cardiac disorder in a human subject, wherein the cardiac disorder is selected from (i) acute or subacute heart failure, (ii) chronic and/or worsening chronic heart failure, (iii) stable heart failure, (iv) a less advanced state of heart failure or from an advanced state of heart failure, (v) heart failure of NYHA stage I and/or II, NYHA stage I, II and/or III or of NYHA stage III and/or IV, and (vi) right-sided heart failure.
A diffuser basket, comprising: an inlet end and an opposite outlet end; a screen portion extending vertically to said outlet end; and a flow modifier positioned within the screen portion; wherein the flow modifier is configured to change the direction of flow of a fluid introduced into the diffuser basket through said inlet end; the diffuser basket characterized in further comprising a lower screen plate connected to the screen portion at the outlet end of the diffuser basket, wherein the screen portion and the lower screen plate are configured to allow flow of the fluid therethrough; a plate element comprising a plurality of openings positioned around a central opening and separated by a plurality of plate segments, wherein the plurality of plate segments are solid portions, and wherein said plate element is connectively coupled to the lower screen plate such that the fluid leaving the outlet end of the diffuser basket can pass through the portions of the screen that are not blocked by the solid portions of the plate element. an inlet end and an opposite outlet end; a screen portion extending vertically to said outlet end; and a flow modifier positioned within the screen portion; wherein the flow modifier is configured to change the direction of flow of a fluid introduced into the diffuser basket through said inlet end; the diffuser basket characterized in further comprising a lower screen plate connected to the screen portion at the outlet end of the diffuser basket, wherein the screen portion and the lower screen plate are configured to allow flow of the fluid therethrough; a plate element comprising a plurality of openings positioned around a central opening and separated by a plurality of plate segments, wherein the plurality of plate segments are solid portions, and wherein said plate element is connectively coupled to the lower screen plate such that the fluid leaving the outlet end of the diffuser basket can pass through the portions of the screen that are not blocked by the solid portions of the plate element.
A liquid chromatograph mass spectrometer, comprising: a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent toward a standard sample container; and a mass spectrometer configured to analyze a mass of a sample; wherein the standard sample container configured to be installed between the liquid feed pump of the liquid chromatograph and the mass spectrometer, wherein the standard sample container is configured to be connected in series with the liquid chromatograph and the mass spectrometer, and to house a standard sample for mass calibration, characterized in that: the standard sample container includes: a cylindrical case that includes an injection hole at a first end and a discharge hole at a second end and that has a flow path direction as a longitudinal direction, and a partition plate configured to be movable along an inner wall of the case and partitioning an inside of the case, and wherein the partition plate is configured to be movable in a direction of the discharge hole due to movement of a mobile phase solution from the injection hole. a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent toward a standard sample container; and a mass spectrometer configured to analyze a mass of a sample; wherein the standard sample container configured to be installed between the liquid feed pump of the liquid chromatograph and the mass spectrometer, wherein the standard sample container is configured to be connected in series with the liquid chromatograph and the mass spectrometer, and to house a standard sample for mass calibration, characterized in that: the standard sample container includes: a cylindrical case that includes an injection hole at a first end and a discharge hole at a second end and that has a flow path direction as a longitudinal direction, and a partition plate configured to be movable along an inner wall of the case and partitioning an inside of the case, and wherein the partition plate is configured to be movable in a direction of the discharge hole due to movement of a mobile phase solution from the injection hole. a cylindrical case that includes an injection hole at a first end and a discharge hole at a second end and that has a flow path direction as a longitudinal direction, and a partition plate configured to be movable along an inner wall of the case and partitioning an inside of the case, and wherein the partition plate is configured to be movable in a direction of the discharge hole due to movement of a mobile phase solution from the injection hole.