A compound of the Formula: wherein: the compound is the (+) isomer of Formula and the configuration of C13 is R; R 1 is selected from the group consisting of alkyl, alkynyl, aryl, and alkyl, alkenyl, alkynyl, or aryl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 2 and R 3 are independently selected from the group consisting of hydrogen, halogen, OH, NH 2, CN, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 4 is selected from the group consisting of hydrogen, halogen, NH 2, CN, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, and OR 4a; R 4a is selected from the group consisting of hydrogen and a bond that forms part of an ether-containing ring; R 5 and R 6 are independently selected from the group consisting of hydrogen, OH, NH 2, SH, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 5 and R 6 together may form a group selected from the group consisting of =O, =NOH, =S, =CHR 5a, and -O(CH 2) 2 O-; R 5a is selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 7 is selected from the group consisting of hydrogen and OR 7a; R 7a is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 8 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 9 and R 10 are independently selected from the group consisting of hydrogen, OH, NH 2, SH, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 9 and R 10 together may form a group selected from the group consisting of =O and =S; R 11 and R 12 are independently selected from the group consisting of hydrogen, OH, halogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 11 and R 12 may form part of an ether-containing ring with R 4a; Y is selected from the group consisting of alkyl, alkyl moieties substituted with aliphatic or cyclic hydrocarbon groups, and alkyl carbonyl; m is an integer from 0 to 8; and ----- is a single bond or a double bond. the compound is the (+) isomer of Formula and the configuration of C13 is R; R 1 is selected from the group consisting of alkyl, alkynyl, aryl, and alkyl, alkenyl, alkynyl, or aryl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 2 and R 3 are independently selected from the group consisting of hydrogen, halogen, OH, NH 2, CN, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 4 is selected from the group consisting of hydrogen, halogen, NH 2, CN, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, and OR 4a; R 4a is selected from the group consisting of hydrogen and a bond that forms part of an ether-containing ring; R 5 and R 6 are independently selected from the group consisting of hydrogen, OH, NH 2, SH, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 5 and R 6 together may form a group selected from the group consisting of =O, =NOH, =S, =CHR 5a, and -O(CH 2) 2 O-; R 5a is selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 7 is selected from the group consisting of hydrogen and OR 7a; R 7a is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 8 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups; R 9 and R 10 are independently selected from the group consisting of hydrogen, OH, NH 2, SH, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 9 and R 10 together may form a group selected from the group consisting of =O and =S; R 11 and R 12 are independently selected from the group consisting of hydrogen, OH, halogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, alkenaryl, alkynaryl, and alkyl, alkenyl, or alkynyl moieties substituted with aliphatic or cyclic hydrocarbon groups, wherein R 11 and R 12 may form part of an ether-containing ring with R 4a; Y is selected from the group consisting of alkyl, alkyl moieties substituted with aliphatic or cyclic hydrocarbon groups, and alkyl carbonyl; m is an integer from 0 to 8; and ----- is a single bond or a double bond.