A compound represented by Formula I: including all stereoisomers, geometric isomers, and tautomers; or a pharmaceutically acceptable salt or solvate of any of the foregoing; wherein: A 1 is phenylene or a six-membered heteroarylene; A 2 is R 1 represents independently for each occurrence halogen, haloalkyl, alkyl, cycloalkyl, heterocycloalkyl, hydroxyl, C 1 -C 6 alkoxy, cyano, -CO 2 R 8, -C R 9, -S R 9, -SO 2 R 9, -SO 2 N(R 10)(R 11), -C N(R 10)(R 11), -N(R 1 0)(R 11), or -N(R 8)C (R 9); R 2 is hydrogen or alkyl; R 3 is aryl, aralkyl, cycloalkyl, -(C(R 8) 2) m -cycloalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, -(C(R 8) 2) m -heterocycloalkyl, alkyl, haloalkyl, hydroxyalkyl, -(C(R 8) 2) m -alkoxyl, -(C(R 8) 2) m -O-(C(R 8) 2) m -alkoxyl, or -(C(R 8) 2) m -CN, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl, and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, hydroxyalkyl, C 1 -C 6 alkoxy, cyano, and -C 1 -C 6 alkylene-CO 2 R 8; R 4 is hydrogen, alkyl, or -C R 9; or R 3 and R 4 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C 1 -C 6 alkoxy; R 5 is hydrogen or alkyl; R 6 is haloalkyl; R 7 is hydrogen, halogen, alkyl, or haloalkyl; R 8 represents independently for each occurrence hydrogen, alkyl, or cycloalkyl; or two occurences of R 8 attached to the same carbon atom are taken together with said carbon atom to form a saturated carbocylic ring; R 9 represents independently for each occurrence alkyl or cycloalkyl; R 10 and R 11 each represent independently for each occurrence hydrogen, alkyl, or cycloalkyl; or R 10 and R 11 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C 1 -C 6 alkoxy; n is O, 1, 2, or 3; and m is 1, 2, 3, 4, or 5. A 1 is phenylene or a six-membered heteroarylene; A 2 is R 1 represents independently for each occurrence halogen, haloalkyl, alkyl, cycloalkyl, heterocycloalkyl, hydroxyl, C 1 -C 6 alkoxy, cyano, -CO 2 R 8, -C R 9, -S R 9, -SO 2 R 9, -SO 2 N(R 10)(R 11), -C N(R 10)(R 11), -N(R 1 0)(R 11), or -N(R 8)C (R 9); R 2 is hydrogen or alkyl; R 3 is aryl, aralkyl, cycloalkyl, -(C(R 8) 2) m -cycloalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, -(C(R 8) 2) m -heterocycloalkyl, alkyl, haloalkyl, hydroxyalkyl, -(C(R 8) 2) m -alkoxyl, -(C(R 8) 2) m -O-(C(R 8) 2) m -alkoxyl, or -(C(R 8) 2) m -CN, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl, and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, hydroxyalkyl, C 1 -C 6 alkoxy, cyano, and -C 1 -C 6 alkylene-CO 2 R 8; R 4 is hydrogen, alkyl, or -C R 9; or R 3 and R 4 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C 1 -C 6 alkoxy; R 5 is hydrogen or alkyl; R 6 is haloalkyl; R 7 is hydrogen, halogen, alkyl, or haloalkyl; R 8 represents independently for each occurrence hydrogen, alkyl, or cycloalkyl; or two occurences of R 8 attached to the same carbon atom are taken together with said carbon atom to form a saturated carbocylic ring; R 9 represents independently for each occurrence alkyl or cycloalkyl; R 10 and R 11 each represent independently for each occurrence hydrogen, alkyl, or cycloalkyl; or R 10 and R 11 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C 1 -C 6 alkoxy; n is O, 1, 2, or 3; and m is 1, 2, 3, 4, or 5.