A multi-imaging device for capturing multiple images of an object, the multi-imaging device comprising: a multiplexed optical system configured to simultaneously form multiple optical images of an object, the multiple optical images being formed at a sensor plane and interleaved at the sensor plane, the multiplexed optical system comprising an objective lens (512,612) configured to form a single image of the object at a first image plane and an array (514, 614) of image-forming elements located at the first image plane, the array of image-forming elements configured to form the interleaved multiple optical images at the sensor plane; a filter fixture located at a conjugate plane (SP') to the sensor plane, wherein said conjugate plane is also an aperture plane for the optical system, the filter fixture configured to allow a user of the multi-imaging device to insert different filter assemblies into the filter fixture; a filter assembly held removably in the filter fixture, the filter assembly being spatially multiplexed with different filter regions (125A-125D) of a size and location appropriate for the multiplexed optical system, the filter regions having different filtering functions, the filter fixture positioning the inserted filter assembly so that different optical images (155A-155D) are filtered by different filter regions (A - D) of the filter assembly before reaching the sensor plane, and a sensor assembly positioned at the sensor plane, the sensor assembly including an array of sensor elements, wherein the array of sensor elements is grouped into subarrays (171 -171) of sensor elements; each of the multiple optical images (155A, 155B...) is subdivided into regions (1A-9A, 1B-9B,...); and the interleaving of the multiple optical images is such that a region for one of the optical images is imaged onto the same subarray (171) of sensor elements as the corresponding region (1B-1D) for each of the other optical images; and wherein the size of at least one filter region in the filter assembly relative to another filter region in the filter assembly is user-adjustable and/or at least one filter region in the filter assembly is user-replaceable with a different filter region. a multiplexed optical system configured to simultaneously form multiple optical images of an object, the multiple optical images being formed at a sensor plane and interleaved at the sensor plane, the multiplexed optical system comprising an objective lens (512,612) configured to form a single image of the object at a first image plane and an array (514, 614) of image-forming elements located at the first image plane, the array of image-forming elements configured to form the interleaved multiple optical images at the sensor plane; a filter fixture located at a conjugate plane (SP') to the sensor plane, wherein said conjugate plane is also an aperture plane for the optical system, the filter fixture configured to allow a user of the multi-imaging device to insert different filter assemblies into the filter fixture; a filter assembly held removably in the filter fixture, the filter assembly being spatially multiplexed with different filter regions (125A-125D) of a size and location appropriate for the multiplexed optical system, the filter regions having different filtering functions, the filter fixture positioning the inserted filter assembly so that different optical images (155A-155D) are filtered by different filter regions (A - D) of the filter assembly before reaching the sensor plane, and a sensor assembly positioned at the sensor plane, the sensor assembly including an array of sensor elements, wherein the array of sensor elements is grouped into subarrays (171 -171) of sensor elements; each of the multiple optical images (155A, 155B...) is subdivided into regions (1A-9A, 1B-9B,...); and the interleaving of the multiple optical images is such that a region for one of the optical images is imaged onto the same subarray (171) of sensor elements as the corresponding region (1B-1D) for each of the other optical images; and wherein the size of at least one filter region in the filter assembly relative to another filter region in the filter assembly is user-adjustable and/or at least one filter region in the filter assembly is user-replaceable with a different filter region.