A method for making lubricant base stock, comprising: performing solvent deasphalting using a C 4 + solvent under effective solvent deasphalting conditions on a feedstock having a T5 boiling point of at least 370°C (or at least 400°C, or at least 450°C, or at least 500°C), the effective solvent deasphalting conditions producing a yield of deasphalted oil of at least 50 wt% of the feedstock; hydroprocessing at least a portion of the deasphalted oil under first effective hydroprocessing conditions to form a hydroprocessed effluent, the at least a portion of the deasphalted oil having an aromatics content of at least 50 wt% and a sulfur content of at least 500 wppm, the hydroprocessing including a first hydrocracking of the deasphalted oil to convert a first wt% relative to 370°C, the first wt% being 30 wt% to 70 wt%, and reducing sulfur content to 200 wppm or less and; separating the hydroprocessed effluent to form at least a fuels boiling range fraction and a bottoms fraction; and hydroprocessing at least a portion of the hydroprocessed bottoms fraction under second effective hydroprocessing conditions to convert a second wt% relative to 370°C, the second wt% being 10 wt% to 70 wt%, the second effective hydroprocessing conditions comprising second hydrocracking conditions and catalytic dewaxing conditions, to form a catalytically dewaxed effluent, wherein a combined conversion of the at least a portion of the deasphalted oil from the first effective hydroprocessing conditions and the second effective hydroprocessing conditions is at least 50 wt% relative to 370°C, and wherein the catalytically dewaxed effluent comprises a 950°F+ (510°C+) portion having a VI of at least 80 and a pour point of -6°C or less. performing solvent deasphalting using a C 4 + solvent under effective solvent deasphalting conditions on a feedstock having a T5 boiling point of at least 370°C (or at least 400°C, or at least 450°C, or at least 500°C), the effective solvent deasphalting conditions producing a yield of deasphalted oil of at least 50 wt% of the feedstock; hydroprocessing at least a portion of the deasphalted oil under first effective hydroprocessing conditions to form a hydroprocessed effluent, the at least a portion of the deasphalted oil having an aromatics content of at least 50 wt% and a sulfur content of at least 500 wppm, the hydroprocessing including a first hydrocracking of the deasphalted oil to convert a first wt% relative to 370°C, the first wt% being 30 wt% to 70 wt%, and reducing sulfur content to 200 wppm or less and; separating the hydroprocessed effluent to form at least a fuels boiling range fraction and a bottoms fraction; and hydroprocessing at least a portion of the hydroprocessed bottoms fraction under second effective hydroprocessing conditions to convert a second wt% relative to 370°C, the second wt% being 10 wt% to 70 wt%, the second effective hydroprocessing conditions comprising second hydrocracking conditions and catalytic dewaxing conditions, to form a catalytically dewaxed effluent, wherein a combined conversion of the at least a portion of the deasphalted oil from the first effective hydroprocessing conditions and the second effective hydroprocessing conditions is at least 50 wt% relative to 370°C, and wherein the catalytically dewaxed effluent comprises a 950°F+ (510°C+) portion having a VI of at least 80 and a pour point of -6°C or less.