A seal structure for a roof of a vehicle having an opening closed by a retractable or removable roof panel, the seal structure comprising: a weather strip which is attached to an edge portion of the opening of the roof, and elastically contacts an outer edge portion of the roof panel closing the opening to seal between the roof panel and the edge portion, characterized in that the edge portion of the opening of the roof includes a lower inclined part extending obliquely downward toward an inside of the vehicle, a shoulder part extending from an upper end of the lower inclined part with a corner formed between the shoulder part and the lower inclined part, and an upper inclined part extending obliquely upward from the shoulder part, the weather strip includes a first sealing part which is attached to the shoulder part, and elastically contacts the outer edge portion of the roof panel closing the opening of the roof, an inclined extension part extending obliquely downward from the first sealing part along the lower inclined part, and a first stopper protruding upward from the first sealing part in a direction opposite to the inclined extension part to receive the outer edge portion of the roof panel closing the opening of the roof, misalignment of the weather strip is controlled by the corner, a locating face on a bottom of the first sealing part is pressed onto the shoulder part on one side of the corner, and a locating face of the inclined extension part is pressed onto the lower inclined part on the other side of the corner, and the first sealing part is adhered to at least one of the shoulder part or the upper inclined part with a double-sided tape. a weather strip which is attached to an edge portion of the opening of the roof, and elastically contacts an outer edge portion of the roof panel closing the opening to seal between the roof panel and the edge portion, characterized in that the edge portion of the opening of the roof includes a lower inclined part extending obliquely downward toward an inside of the vehicle, a shoulder part extending from an upper end of the lower inclined part with a corner formed between the shoulder part and the lower inclined part, and an upper inclined part extending obliquely upward from the shoulder part, the weather strip includes a first sealing part which is attached to the shoulder part, and elastically contacts the outer edge portion of the roof panel closing the opening of the roof, an inclined extension part extending obliquely downward from the first sealing part along the lower inclined part, and a first stopper protruding upward from the first sealing part in a direction opposite to the inclined extension part to receive the outer edge portion of the roof panel closing the opening of the roof, misalignment of the weather strip is controlled by the corner, a locating face on a bottom of the first sealing part is pressed onto the shoulder part on one side of the corner, and a locating face of the inclined extension part is pressed onto the lower inclined part on the other side of the corner, and the first sealing part is adhered to at least one of the shoulder part or the upper inclined part with a double-sided tape.