A system comprising disposable extraction-separation chromatography cartridges (501a, 501b, 501c), wherein each of the disposable extraction-separation chromatography cartridges comprises: a barrel having a barrel first end that is open and a barrel second end opposite the barrel first end; a column segment, having a column segment first end connected to the barrel second end and a column segment second end opposite the column segment first end; a column (205,505) spanning the column segment, the column filled with a sorbent material and having a column first end in fluid communication with the barrel second end and a column second end opposite the column first end; and the column segment first end comprises a mobile phase source port in fluid communication with the column first end; a well-plate comprising a plurality of cartridge wells wherein said extraction-separation chromatography cartridges (501a, 501b, 501c) can be inserted; a first solvent supply configured to deliver a first solvent to the barrel of an extraction-separation chromatography cartridge within any of the plurality of cartridge wells; a mobile phase source configured to deliver a mobile phase solvent to the first end of the column of an extraction-separation chromatography cartridge within any of the plurality of cartridge wells; and an outlet channel configured to receive solvent from a second end of the column which is opposite the first end of the column, said system being characterized in that the well-plate comprises a reinforcing wall configured to surround and support the exterior of each of extraction-separation chromatography cartridge within any of the plurality of cartridge wells along the entire length of the cartridge. disposable extraction-separation chromatography cartridges (501a, 501b, 501c), wherein each of the disposable extraction-separation chromatography cartridges comprises: a barrel having a barrel first end that is open and a barrel second end opposite the barrel first end; a column segment, having a column segment first end connected to the barrel second end and a column segment second end opposite the column segment first end; a column (205,505) spanning the column segment, the column filled with a sorbent material and having a column first end in fluid communication with the barrel second end and a column second end opposite the column first end; and the column segment first end comprises a mobile phase source port in fluid communication with the column first end; a barrel having a barrel first end that is open and a barrel second end opposite the barrel first end; a column segment, having a column segment first end connected to the barrel second end and a column segment second end opposite the column segment first end; a column (205,505) spanning the column segment, the column filled with a sorbent material and having a column first end in fluid communication with the barrel second end and a column second end opposite the column first end; and the column segment first end comprises a mobile phase source port in fluid communication with the column first end; a well-plate comprising a plurality of cartridge wells wherein said extraction-separation chromatography cartridges (501a, 501b, 501c) can be inserted; a first solvent supply configured to deliver a first solvent to the barrel of an extraction-separation chromatography cartridge within any of the plurality of cartridge wells; a mobile phase source configured to deliver a mobile phase solvent to the first end of the column of an extraction-separation chromatography cartridge within any of the plurality of cartridge wells; and an outlet channel configured to receive solvent from a second end of the column which is opposite the first end of the column, said system being characterized in that the well-plate comprises a reinforcing wall configured to surround and support the exterior of each of extraction-separation chromatography cartridge within any of the plurality of cartridge wells along the entire length of the cartridge.