A compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is -CF 3; Y is selected from hydrogen, -(C 1 -C 4)alkylene-N(R 2)(R 3), -CH=N-OR 2, -C -N(R 2)(R 4), -NO 2, -COOH, -OH, -N=CH-N(R 2)(R 3), -N(R 2)(R 3), -N(R F)-C -[C(R 5a)(R 5b)] 1-4 -N(R 2)(R 3), -N(R F)-C -(C 1 -C 6)alkyl, -N(R F)-C -heterocyclyl, -N(R F)-C -carbocyclyl, -N(R F)-S m -(C 1 -C 4)alkylene-N(R 2)(R 3), -N(R F)-S m -N(R 2)(R 4), and -N(R F)-S m -(C 1 -C 4) alkylene-carbocyclyl, wherein: each R 2 is independently selected from hydrogen, and (C 1 -C 3)alkyl; each R 3 is independently selected from hydrogen, (C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -(C 0 -C 6) alkylene-carbocyclyl, -(C 0 -C 6)alkylene-heterocyclyl, -S m -(C 1 -C 6)alkyl, -S m -carbocyclyl, and -S m -heterocyclyl; and each R 4 is independently selected from hydrogen, (C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -(C 0 -C 6) alkylene-carbocyclyl, and -(C 0 -C 6)alkylene-heterocyclyl; or R 2 and R 3, taken together with the nitrogen atom to which they are bound form a heterocyclyl, wherein the heterocyclyl optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O; each R 5a and each R 5b is independently selected from hydrogen, (C 1 -C 6)alkyl, carbocyclyl, heterocyclyl, or a naturally occurring amino acid side chain moiety, or R 5a and R 5b taken together with the carbon atom to which they are bound form a 3-7 membered saturated carbocyclyl or a 4-7 membered saturated heterocyclyl, wherein the saturated heterocyclyl formed by R 5a and R 5b optionally comprises one to two additional heteroatoms independently selected from N, S and O, R F is hydrogen or (C 1 -C 3)alkyl; each m is 1 or 2, wherein: each carbocyclyl or heterocyclyl is optionally and independently substituted with one or more substituents independently selected from chloro, fluoro, (C 1 -C 4)alkyl, -OH, -O-(C 1 -C 4)alkyl, fluoro-substituted-(C 1 -C 4)alkyl, -C -(C 1 -C 4)alkyl, -C -(fluoro-substituted-(C 1 -C 4)alkyl), and -N(R G)(R G); each R G is hydrogen or (C 1 -C 4)alkyl, wherein each alkyl in the group represented by R G is optionally and independently substituted with one or more substituents independently selected from -(C 1 -C 4)alkyl, (C 3 -C 6)cycloalkyl, halo, -OH, -O-(C 1 -C 4)alkyl, and -(C 1 -C 4)alkylene-O-(C 1 -C 4)alkyl; and each alkyl is optionally and independently substituted with one or more substituents independently selected from fluoro, chloro, -O-(C 1 -C 4)alkyl, and fluoro-substituted-(C 1 -C 4)alkyl. X is -CF 3; Y is selected from hydrogen, -(C 1 -C 4)alkylene-N(R 2)(R 3), -CH=N-OR 2, -C -N(R 2)(R 4), -NO 2, -COOH, -OH, -N=CH-N(R 2)(R 3), -N(R 2)(R 3), -N(R F)-C -[C(R 5a)(R 5b)] 1-4 -N(R 2)(R 3), -N(R F)-C -(C 1 -C 6)alkyl, -N(R F)-C -heterocyclyl, -N(R F)-C -carbocyclyl, -N(R F)-S m -(C 1 -C 4)alkylene-N(R 2)(R 3), -N(R F)-S m -N(R 2)(R 4), and -N(R F)-S m -(C 1 -C 4) alkylene-carbocyclyl, wherein: each R 2 is independently selected from hydrogen, and (C 1 -C 3)alkyl; each R 3 is independently selected from hydrogen, (C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -(C 0 -C 6) alkylene-carbocyclyl, -(C 0 -C 6)alkylene-heterocyclyl, -S m -(C 1 -C 6)alkyl, -S m -carbocyclyl, and -S m -heterocyclyl; and each R 4 is independently selected from hydrogen, (C 1 -C 6)alkyl, -O-(C 1 -C 6)alkyl, -(C 0 -C 6) alkylene-carbocyclyl, and -(C 0 -C 6)alkylene-heterocyclyl; or R 2 and R 3, taken together with the nitrogen atom to which they are bound form a heterocyclyl, wherein the heterocyclyl optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O; each R 5a and each R 5b is independently selected from hydrogen, (C 1 -C 6)alkyl, carbocyclyl, heterocyclyl, or a naturally occurring amino acid side chain moiety, or R 5a and R 5b taken together with the carbon atom to which they are bound form a 3-7 membered saturated carbocyclyl or a 4-7 membered saturated heterocyclyl, wherein the saturated heterocyclyl formed by R 5a and R 5b optionally comprises one to two additional heteroatoms independently selected from N, S and O, R F is hydrogen or (C 1 -C 3)alkyl; each m is 1 or 2, wherein: each carbocyclyl or heterocyclyl is optionally and independently substituted with one or more substituents independently selected from chloro, fluoro, (C 1 -C 4)alkyl, -OH, -O-(C 1 -C 4)alkyl, fluoro-substituted-(C 1 -C 4)alkyl, -C -(C 1 -C 4)alkyl, -C -(fluoro-substituted-(C 1 -C 4)alkyl), and -N(R G)(R G); each R G is hydrogen or (C 1 -C 4)alkyl, wherein each alkyl in the group represented by R G is optionally and independently substituted with one or more substituents independently selected from -(C 1 -C 4)alkyl, (C 3 -C 6)cycloalkyl, halo, -OH, -O-(C 1 -C 4)alkyl, and -(C 1 -C 4)alkylene-O-(C 1 -C 4)alkyl; and each alkyl is optionally and independently substituted with one or more substituents independently selected from fluoro, chloro, -O-(C 1 -C 4)alkyl, and fluoro-substituted-(C 1 -C 4)alkyl.