An applicator instrument (100, 8100) for the endoscopic delivery of a flowable hemostat, said instrument (100, 8100) comprising: an inner shaft (124, 8124) having a proximal end and a distal end (148, 8148); an outer shaft (106, 8106) having a proximal end and a distal end (114, 8114), said outer shaft (106, 8106) surrounding said inner shaft (124, 8124); a first lumen extending between said inner (124, 8124) and outer (106, 8106) shafts; a second lumen (160, 8160) extending though said inner shaft (124, 8124) to a distal opening at the distal end (148, 8148) of said inner shaft (124, 8124); an inflatable balloon (112, 8112) secured to the distal end of said instrument, said inflatable balloon (112, 8112) being in communication with said first lumen and having a proximal end (150, 8150) secured to said outer shaft (106, 8106) and a distal end (152, 8152) surrounding the distal opening of said second lumen and being secured to said inner shaft (124, 8124), wherein the distal end (152, 8152) of said balloon (112, 8112) is inverted and the inverted distal end (152, 8152) of said balloon (112, 8112) is secured to the distal end (148, 8148) of said inner shaft (124, 8124). a first actuator (186, 8186) in communication with said first lumen for selectively inflating said balloon (112, 8112); and a second actuator (1210, 8210) in communication with said second lumen for introducing a flowable material into said second lumen for discharging said flowable material from the distal opening at the distal end (148, 8148) of said inner shaft (124, 8124); and a third actuator coupled with said outer shaft for moving the distal end of said outer shaft distally relative to the distal end of said inner shaft. an inner shaft (124, 8124) having a proximal end and a distal end (148, 8148); an outer shaft (106, 8106) having a proximal end and a distal end (114, 8114), said outer shaft (106, 8106) surrounding said inner shaft (124, 8124); a first lumen extending between said inner (124, 8124) and outer (106, 8106) shafts; a second lumen (160, 8160) extending though said inner shaft (124, 8124) to a distal opening at the distal end (148, 8148) of said inner shaft (124, 8124); an inflatable balloon (112, 8112) secured to the distal end of said instrument, said inflatable balloon (112, 8112) being in communication with said first lumen and having a proximal end (150, 8150) secured to said outer shaft (106, 8106) and a distal end (152, 8152) surrounding the distal opening of said second lumen and being secured to said inner shaft (124, 8124), wherein the distal end (152, 8152) of said balloon (112, 8112) is inverted and the inverted distal end (152, 8152) of said balloon (112, 8112) is secured to the distal end (148, 8148) of said inner shaft (124, 8124). a first actuator (186, 8186) in communication with said first lumen for selectively inflating said balloon (112, 8112); and a second actuator (1210, 8210) in communication with said second lumen for introducing a flowable material into said second lumen for discharging said flowable material from the distal opening at the distal end (148, 8148) of said inner shaft (124, 8124); and a third actuator coupled with said outer shaft for moving the distal end of said outer shaft distally relative to the distal end of said inner shaft.