mhurhangee/ep-ind-claims huggingface dataset:
A compound comprising a modified oligonucleotide having 20-30 linked nucleosides, or a salt thereof, wherein said modified oligonucleotide is 100% complementary to a nucleic acid encoding human apolipoprotein B of any of SEQ ID NOs: 1-9, and wherein the modified oligonucleotide comprises the nucleobase sequence of SEQ ID NO: 10 and comprises: a gap segment consisting of ten consecutive linked 2' deoxyribonucleosides; a 5' wing segment consisting of five consecutive modified nucleosides; and a 3' wing segment consisting of five consecutive modified nucleosides, wherein the gap segment is positioned between the 5' wing and the 3' wing segment; wherein each nucleoside of each wing segment comprises a 2'-O-methoxyethyl sugar moiety; wherein each cytosine is a 5'-methylcytosine; and wherein each internucleoside linkage is a phosphorothioate linkage, for use in treating a condition associated with elevated ApoCIII levels in a human subject with elevated apolipoprotein C III levels, wherein said treatment comprises lowering plasma apolipoprotein C III levels in the subject, and wherein the subject does not have elevated plasma apolipoprotein B concentrations, wherein the condition associated with elevated apolipoprotein C III levels is selected from the group consisting of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, elevated total cholesterol, elevated LDL-C, elevated VLDL-C, elevated IDL-C, elevated lipoprotein concentrations, elevated plasma glucose concentrations, elevated plasma triglyceride concentrations, elevated liver triglyceride concentrations and hepatic steatosis. a gap segment consisting of ten consecutive linked 2' deoxyribonucleosides; a 5' wing segment consisting of five consecutive modified nucleosides; and a 3' wing segment consisting of five consecutive modified nucleosides, wherein the gap segment is positioned between the 5' wing and the 3' wing segment; wherein each nucleoside of each wing segment comprises a 2'-O-methoxyethyl sugar moiety; wherein each cytosine is a 5'-methylcytosine; and wherein each internucleoside linkage is a phosphorothioate linkage, for use in treating a condition associated with elevated ApoCIII levels in a human subject with elevated apolipoprotein C III levels, wherein said treatment comprises lowering plasma apolipoprotein C III levels in the subject, and wherein the subject does not have elevated plasma apolipoprotein B concentrations, wherein the condition associated with elevated apolipoprotein C III levels is selected from the group consisting of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, elevated total cholesterol, elevated LDL-C, elevated VLDL-C, elevated IDL-C, elevated lipoprotein concentrations, elevated plasma glucose concentrations, elevated plasma triglyceride concentrations, elevated liver triglyceride concentrations and hepatic steatosis.
A device comprising: a plurality of substrates comprising one or more troughs, wherein the plurality of substrates are disposed such that the one or more troughs form at least one enclosure; and at least one superconducting layer (132, 134) covering at least a portion of the at least one enclosure, wherein the at least one enclosure is configured to form at least one three-dimensional cavity resonator such that electromagnetic radiation at one or more frequencies resonates within the at least one three-dimensional cavity resonator. a plurality of substrates comprising one or more troughs, wherein the plurality of substrates are disposed such that the one or more troughs form at least one enclosure; and at least one superconducting layer (132, 134) covering at least a portion of the at least one enclosure, wherein the at least one enclosure is configured to form at least one three-dimensional cavity resonator such that electromagnetic radiation at one or more frequencies resonates within the at least one three-dimensional cavity resonator.
A system for synchronous service-flow transmission in a heterogeneous network, characterized in that the system comprises an access point and an access-network controller, wherein the access-network controller includes a synchronization managing unit, the access point is configured to collect a parameter on a wireless-network channel, and report the parameter on the wireless-network channel to the synchronization managing unit; and the synchronization managing unit is configured to dynamically adjust the received parameter on the wireless-network channel, and transmit the adjusted parameter to each service-flow channel, such that a sub-service-flow on each service-flow channel is transmitted according to adjusted parameters to implement synchronization between service-flows, wherein the synchronization managing unit is configured for: determining a state of synchronization between sub-service-flows according to two received acknowledging ACK messages by comparing time of receiving a present acknowledging ACK message and time of receiving a last acknowledging ACK message; when synchronization control is required, acquiring QoS information in sending a service, and determining a synchronization-control policy to be adopted according to the QoS information; and dynamically adjusting the parameter based on the determined synchronization-control policy, wherein the synchronization managing unit receives an acknowledging ACK message sent by a terminal after the terminal receives a sub-service-flow, wherein the parameter on the wireless-network channel comprises a serving interval S of the sub-service-flow and a transmission time T in transmitting the sub-service-flow on the wireless-network channel; the transmission time T is a number of packets sent in a single competition period of the wireless-network channel; the greater the T, the more data packets are sent in a single competition period, and the faster a sending rate is. determining a state of synchronization between sub-service-flows according to two received acknowledging ACK messages by comparing time of receiving a present acknowledging ACK message and time of receiving a last acknowledging ACK message; when synchronization control is required, acquiring QoS information in sending a service, and determining a synchronization-control policy to be adopted according to the QoS information; and dynamically adjusting the parameter based on the determined synchronization-control policy, wherein the synchronization managing unit receives an acknowledging ACK message sent by a terminal after the terminal receives a sub-service-flow, wherein the parameter on the wireless-network channel comprises a serving interval S of the sub-service-flow and a transmission time T in transmitting the sub-service-flow on the wireless-network channel; the transmission time T is a number of packets sent in a single competition period of the wireless-network channel; the greater the T, the more data packets are sent in a single competition period, and the faster a sending rate is.
Method for installing a virtualized network function, contributing to the implementation of a communication service, in a data centre of a set of data centres (10, 20, 30) of a virtualized communication architecture, comprising the following steps implemented in an entity for operating the service: - sending to an entity for managing profiles a message to obtain a set of placement parameters of the virtualized network function that are specific to the type of said virtualized network function, the set being called a profile, said message containing an identifier of said virtualized function, - obtaining, from the entity for managing profiles, a profile corresponding to the type of said virtualized network function, - determining a first data centre suitable for said virtualized network function to be installed depending on the obtained profile, - modifying the profile by adding a datum identifying the determined first data centre, - sending to an entity for administrating the virtualized architecture a request, comprising the modified profile, for installation of the virtualized network function in the determined first data centre, - determining a second data centre of the set depending on the modified profile with a view to installing the virtualized network function, following reception, from the entity for administrating the virtualized architecture, of a message containing information on non-installation of the virtualized network function in the first data centre. - sending to an entity for managing profiles a message to obtain a set of placement parameters of the virtualized network function that are specific to the type of said virtualized network function, the set being called a profile, said message containing an identifier of said virtualized function, - obtaining, from the entity for managing profiles, a profile corresponding to the type of said virtualized network function, - determining a first data centre suitable for said virtualized network function to be installed depending on the obtained profile, - modifying the profile by adding a datum identifying the determined first data centre, - sending to an entity for administrating the virtualized architecture a request, comprising the modified profile, for installation of the virtualized network function in the determined first data centre, - determining a second data centre of the set depending on the modified profile with a view to installing the virtualized network function, following reception, from the entity for administrating the virtualized architecture, of a message containing information on non-installation of the virtualized network function in the first data centre.
A controlled pressure drilling system, comprising: an evaluation device in fluid communication with flow of drilling fluid from a wellbore, the evaluation device measuring fluid content in the drilling fluid from the wellbore upstream of a gas separator; and a controller (118, 170) operatively coupled to the evaluation device, the controller (118, 170) monitoring one or more parameters indicative of at least a fluid influx in the wellbore, the controller (118, 170) determining passage of the drilling fluid associated with the fluid influx from the wellbore past the evaluation device and determining the fluid content associated with the fluid influx, the controlled pressure drilling system characterised in that the controller determines a volume of the fluid content associated with the fluid influx by correlating the determined fluid content to density of the drilling fluid. an evaluation device in fluid communication with flow of drilling fluid from a wellbore, the evaluation device measuring fluid content in the drilling fluid from the wellbore upstream of a gas separator; and a controller (118, 170) operatively coupled to the evaluation device, the controller (118, 170) monitoring one or more parameters indicative of at least a fluid influx in the wellbore, the controller (118, 170) determining passage of the drilling fluid associated with the fluid influx from the wellbore past the evaluation device and determining the fluid content associated with the fluid influx, the controlled pressure drilling system characterised in that the controller determines a volume of the fluid content associated with the fluid influx by correlating the determined fluid content to density of the drilling fluid.
An aqueous polymer latex of a film-forming copolymer obtainable by aqueous emulsion polymerisation of monomers M, which comprise at least 80% by weight, based on the monomers M, of - at least one non-ionic monomer M1, which is selected from C 1 -C 20 -alkyl esters of acrylic acid, C 5 -C 20 -cycloalkyl esters of acrylic acid, C 1 -C 20 -alkyl esters of methacrylic acid, C 5 -C 20 -cycloalkyl esters of methacrylic acid, and monovinyl aromatic monomers; - one or more monoethylenically unsaturated monomers M2, which are selected from monoethylenically unsaturated monocarboxylic acids having 3 to 6 carbon atoms and monoethylenically unsaturated dicarboxylic acids having 4 to 6 carbon atoms; where the polymer latex contains an emulsifier combination comprising i. at least one first emulsifier, which is selected from salts of sulfated ethoxylated C 8 -C 20 -alkanols having a degree of ethoxylation in the range from 5 to 20 and sulfated ethoxylated tristyrylphenols having a degree of ethoxylation in the range from 5 to 20; ii. at least one second emulsifier, which is selected from salts of a sulfated ethoxylated C 8 -C 20 -alkanol having a degree of ethoxylation in the range from 21 to 50 and sulfated ethoxylated tristyrylphenols having a degree of ethoxylation in the range from 21 to 50. - at least one non-ionic monomer M1, which is selected from C 1 -C 20 -alkyl esters of acrylic acid, C 5 -C 20 -cycloalkyl esters of acrylic acid, C 1 -C 20 -alkyl esters of methacrylic acid, C 5 -C 20 -cycloalkyl esters of methacrylic acid, and monovinyl aromatic monomers; - one or more monoethylenically unsaturated monomers M2, which are selected from monoethylenically unsaturated monocarboxylic acids having 3 to 6 carbon atoms and monoethylenically unsaturated dicarboxylic acids having 4 to 6 carbon atoms; i. at least one first emulsifier, which is selected from salts of sulfated ethoxylated C 8 -C 20 -alkanols having a degree of ethoxylation in the range from 5 to 20 and sulfated ethoxylated tristyrylphenols having a degree of ethoxylation in the range from 5 to 20; ii. at least one second emulsifier, which is selected from salts of a sulfated ethoxylated C 8 -C 20 -alkanol having a degree of ethoxylation in the range from 21 to 50 and sulfated ethoxylated tristyrylphenols having a degree of ethoxylation in the range from 21 to 50.
Method for producing an immunoglobulin solution comprising a) providing an immunoglobulin solution with a concentration of at least 100 g/l, b) applying the immunoglobulin solution to a combination of a first and second filter unit, whereby the first filter unit comprises a pre-filter with a pore size of 3.0 μm and a main-filter with a pore size of 0.8 μm and the second filter unit comprises a pre-filter with a pore size of 0.45 μm and a main-filter with a pore size of 0.22 μm with a pressure of from 0.1 to 4.0 bar, and thereby producing an immunoglobulin solution. a) providing an immunoglobulin solution with a concentration of at least 100 g/l, b) applying the immunoglobulin solution to a combination of a first and second filter unit, whereby the first filter unit comprises a pre-filter with a pore size of 3.0 μm and a main-filter with a pore size of 0.8 μm and the second filter unit comprises a pre-filter with a pore size of 0.45 μm and a main-filter with a pore size of 0.22 μm with a pressure of from 0.1 to 4.0 bar, and thereby producing an immunoglobulin solution.
A wind turbine with a vertical axis of rotation comprising a tower, wherein a wind wheel and a motor are mounted at the top of the tower, the wind wheel comprises a plurality of blades, an adaptive variable pitch device is mounted on each blade, and the adaptive variable pitch devices are mounted on a rotor of the motor; a wind deflector is further mounted on the tower, the wind deflector is located below the wind wheel, and the wind deflector is used for accumulating wind energy in all directions and blowing the wind energy vertically to the wind wheel, so that the wind wheel drives the rotor of the motor to rotate under the action of wind speed to generate electrical energy, characterized in that the blades are of a horizontal axis lift type blade and the rotating parts of the wind turbine are concealed inside the wind deflector, wherein the adaptive variable pitch device comprises a first support bearing, a blade root shaft, a torsion spring and a second support bearing; the blade root shaft is fixedly connected to the blade, the blade root shaft is connected to the first support bearing and the second support bearing respectively, the first support bearing and the second support bearing are both mounted on the rotor of the motor, the torsion spring is also sheathed on the blade root shaft, and the torsion spring is also fixed to the rotor of the motor and wherein a protective cover is further mounted on the tower, and the protective cover is mounted above the wind wheel, wherein the number of blades is at least three and wherein the adaptive variable pitch devices are mounted equidistantly on the rotor of the motor.
A method, comprising: manufacturing an impeller by: cutting a tube such that the cut tube defines a structure having first and second end portions at proximal and distal ends of the structure, the end portions being connected to one another by a plurality of elongate elements; causing the plurality of elongate elements to radially expand and form a plurality of helical elongate elements, by axially compressing the structure; coupling a material to the plurality of helical elongate elements, such that the helical elongate elements with the material coupled thereto define one or more blades of the impeller, the method characterized in that the coupling of the material to the structure is performed by: dipping at least a portion of the structure into the material while the material is in a liquid state, drying the material, while the material is being supported by the plurality of helical elongate elements, and during the drying of material, rotating the structure about its longitudinal axis, such as to facilitate the formation of a film of the material having a uniform thickness. cutting a tube such that the cut tube defines a structure having first and second end portions at proximal and distal ends of the structure, the end portions being connected to one another by a plurality of elongate elements; causing the plurality of elongate elements to radially expand and form a plurality of helical elongate elements, by axially compressing the structure; coupling a material to the plurality of helical elongate elements, such that the helical elongate elements with the material coupled thereto define one or more blades of the impeller, the method characterized in that the coupling of the material to the structure is performed by: dipping at least a portion of the structure into the material while the material is in a liquid state, drying the material, while the material is being supported by the plurality of helical elongate elements, and during the drying of material, rotating the structure about its longitudinal axis, such as to facilitate the formation of a film of the material having a uniform thickness. dipping at least a portion of the structure into the material while the material is in a liquid state, drying the material, while the material is being supported by the plurality of helical elongate elements, and during the drying of material, rotating the structure about its longitudinal axis, such as to facilitate the formation of a film of the material having a uniform thickness.
A liquid crystal phase shifter, comprising a first substrate and a second substrate opposite to each other, and a liquid crystal layer between the first substrate and the second substrate; wherein the first substrate comprises a first base plate and a first electrode layer at a side of the first base plate proximal to the liquid crystal layer; the second substrate comprises a second base plate and a second electrode layer at a side of the second base plate proximal to the liquid crystal layer; and the first electrode layer comprises a main body structure having a first side and a second side opposite to each other with respect to a length direction of the main body structure, and a plurality of branch structures connected to at least one of the first side and the second side of the main body structure, wherein the second electrode layer is in a peripheral region of the second base plate, and an orthographic projection of the second electrode layer on the first base plate partially overlaps an orthographic projection of at least one of the plurality of branch structures on the first base plate, wherein each of the first side and the second side of the main body structure is connected with the plurality of branch structures, and wherein the plurality of branch structures connected to the first side and the plurality of branch structures connected to the second side are symmetric about the main body structure. a first substrate and a second substrate opposite to each other, and a liquid crystal layer between the first substrate and the second substrate; wherein the first substrate comprises a first base plate and a first electrode layer at a side of the first base plate proximal to the liquid crystal layer; the second substrate comprises a second base plate and a second electrode layer at a side of the second base plate proximal to the liquid crystal layer; and the first electrode layer comprises a main body structure having a first side and a second side opposite to each other with respect to a length direction of the main body structure, and a plurality of branch structures connected to at least one of the first side and the second side of the main body structure, wherein the second electrode layer is in a peripheral region of the second base plate, and an orthographic projection of the second electrode layer on the first base plate partially overlaps an orthographic projection of at least one of the plurality of branch structures on the first base plate, wherein each of the first side and the second side of the main body structure is connected with the plurality of branch structures, and wherein the plurality of branch structures connected to the first side and the plurality of branch structures connected to the second side are symmetric about the main body structure.
An miRNA for use in the treatment of pre-eclampsia, wherein the miRNA is selected from microRNA-122 and microRNA-374b, or functional fragments thereof retaining the same biological activity as the native miRNA, and wherein the miRNA is in its native or pegylated form.
Apparatus for assessing the functionality of a lung compartment in a patient, the apparatus comprising: a catheter having a distal end (102 and a passage; an occluding member for sealing the distal end of the catheter in an airway feeding the lung compartment, the occluding member being adapted to be expanded in an airway which feeds the lung compartment such that access to the lung compartment is provided only through the passage of the catheter when the occluding member is expanded; a one-way flow element adapted to be disposed within or in-line with the passage of the catheter so that flow in a proximal-to-distal direction is allowed and flow in a distal-to-proximal direction is inhibited or prevented, thereby allowing air to enter the lung compartment through the passage in the catheter while the patient is inhaling and blocking air from being expelled from the lung compartment through the catheter passage while the patient is exhaling; measuring means for measuring flow into the lung compartment; and determining means for determining whether collateral ventilation is present in the lung compartment based on the measured flow into the lung compartment. a catheter having a distal end (102 and a passage; an occluding member for sealing the distal end of the catheter in an airway feeding the lung compartment, the occluding member being adapted to be expanded in an airway which feeds the lung compartment such that access to the lung compartment is provided only through the passage of the catheter when the occluding member is expanded; a one-way flow element adapted to be disposed within or in-line with the passage of the catheter so that flow in a proximal-to-distal direction is allowed and flow in a distal-to-proximal direction is inhibited or prevented, thereby allowing air to enter the lung compartment through the passage in the catheter while the patient is inhaling and blocking air from being expelled from the lung compartment through the catheter passage while the patient is exhaling; measuring means for measuring flow into the lung compartment; and determining means for determining whether collateral ventilation is present in the lung compartment based on the measured flow into the lung compartment.