A compound having Formula or a therapeutically acceptable salt thereof, wherein X is benzo[d]thiazolyl, thiazolo[5,4-b]pyridinyl, thiazolo[4.5-c]pyridinyl, imidazo[1,2-a]pyridinyl, thiazolo[5,4-c]pyridinyl, thiazolo[4,5-b]pyridinyl, imidazo[1,2-a]pyrazinyl, or imidazo[1,2-b]pyridazinyl; Y 1 is pyrrolyl, pyrazolyl, triazolyl or pyridinyl; wherein Y 1 is optionally substituted with one, or two substituents independently selected from the group consisting of R 5, CN, F, Cl, Br and I; L 1 is selected from the group consisting of (CR 6 R 7) q, (CR 6 R 7) s -O-(CR 6 R 7) r,(CR 6 R 7) s -S-(CR 6 R 7) r, (CR 6 R 7) s -S 2 -(CR 6 R 7) r, (CR 6 R 7) s -NR 6A C -(CR 6 R 7) r, (CR 6 R 7) s -C NR 6A -(CR 6 R 7) r, (CR 6 R 7) s -NR 6A -(CR 6 R 7) r, and (CR 6 R 7) s -S 2 NR 6A -(CR 6 R 7) r; Y 2 is C 8-14 cycloalkyl, or C 8-14 heterocycloalkyl; wherein Y 2 is optionally substituted with one, two, or three substituents independently selected from the group consisting of R 8, OR 8, SO 2 R 8, CO R 8, OH, F, Cl, Br and I; Z 1 is selected from the group consisting of R 1 is absent: R 2, at each occurrence, is independently deuterium or C 1-6 alkyl; R 3 is absent; R 5, at each occurrence, is independently C 1-6 alky; R 6A is independently selected from the group consisting of hydrogen and C 1-6 alkyl; R 6 and R 7, at each occurrence, are each independently hydrogen; R 8, at each occurrence, is independently selected from the group consisting of C 1-6 alkyl, heterocyclyl and cycloalkyl; wherein the R 8 C 1-6 alkyl is optionally substituted with one substituent independently selected from the group consisting of R 16, OR 16, SO 2 R 16, and NHR 16; R k, at each occurrence, is independently selected from the group consisting of C 1-6 alkyl, C 3-7 heterocycloalkyl, C 3-7 cycloalkyl and C 1-6 haloalkyl; R 16, at each occurrence, is independently selected from the group consisting of C 1-4 alkyl, phenyl, and heterocycloalkyl; wherein the R 16 C 1-4 alkyl is optionally substituted with one substituent independently selected from the group consisting of OCH 3, OCH 2 CH 2 OCH 3, and OCH 2 CH 2 NHCH 3; q is 1 or 2; s is 0 or 1; r is 0 or 1; wherein the sum of s and r is 0 or 1; m is 0: n is 0, 1, or 2; and p is 0. X is benzo[d]thiazolyl, thiazolo[5,4-b]pyridinyl, thiazolo[4.5-c]pyridinyl, imidazo[1,2-a]pyridinyl, thiazolo[5,4-c]pyridinyl, thiazolo[4,5-b]pyridinyl, imidazo[1,2-a]pyrazinyl, or imidazo[1,2-b]pyridazinyl; Y 1 is pyrrolyl, pyrazolyl, triazolyl or pyridinyl; wherein Y 1 is optionally substituted with one, or two substituents independently selected from the group consisting of R 5, CN, F, Cl, Br and I; L 1 is selected from the group consisting of (CR 6 R 7) q, (CR 6 R 7) s -O-(CR 6 R 7) r,(CR 6 R 7) s -S-(CR 6 R 7) r, (CR 6 R 7) s -S 2 -(CR 6 R 7) r, (CR 6 R 7) s -NR 6A C -(CR 6 R 7) r, (CR 6 R 7) s -C NR 6A -(CR 6 R 7) r, (CR 6 R 7) s -NR 6A -(CR 6 R 7) r, and (CR 6 R 7) s -S 2 NR 6A -(CR 6 R 7) r; Y 2 is C 8-14 cycloalkyl, or C 8-14 heterocycloalkyl; wherein Y 2 is optionally substituted with one, two, or three substituents independently selected from the group consisting of R 8, OR 8, SO 2 R 8, CO R 8, OH, F, Cl, Br and I; Z 1 is selected from the group consisting of R 1 is absent: R 2, at each occurrence, is independently deuterium or C 1-6 alkyl; R 3 is absent; R 5, at each occurrence, is independently C 1-6 alky; R 6A is independently selected from the group consisting of hydrogen and C 1-6 alkyl; R 6 and R 7, at each occurrence, are each independently hydrogen; R 8, at each occurrence, is independently selected from the group consisting of C 1-6 alkyl, heterocyclyl and cycloalkyl; wherein the R 8 C 1-6 alkyl is optionally substituted with one substituent independently selected from the group consisting of R 16, OR 16, SO 2 R 16, and NHR 16; R k, at each occurrence, is independently selected from the group consisting of C 1-6 alkyl, C 3-7 heterocycloalkyl, C 3-7 cycloalkyl and C 1-6 haloalkyl; R 16, at each occurrence, is independently selected from the group consisting of C 1-4 alkyl, phenyl, and heterocycloalkyl; wherein the R 16 C 1-4 alkyl is optionally substituted with one substituent independently selected from the group consisting of OCH 3, OCH 2 CH 2 OCH 3, and OCH 2 CH 2 NHCH 3; q is 1 or 2; s is 0 or 1; r is 0 or 1; wherein the sum of s and r is 0 or 1; m is 0: n is 0, 1, or 2; and p is 0.