A liquefaction system (100; 200; 300; 400), comprising: a first heat exchanger configured to receive a natural gas stream from a natural gas source and cool at least a first portion of the natural gas stream to liquefied natural gas; a first compression assembly fluidly coupled to the first heat exchanger and configured to circulate a first refrigerant through the first heat exchanger to cool the first portion of the natural gas stream to the liquefied natural gas, the first compression assembly comprising a plurality of first refrigerant compressors (126a-f) configured to compress the first refrigerant; and a plurality of turbines (132a-f) configured to drive the plurality of first refrigerant compressors (126a-f); a precooler assembly fluidly coupled to the first compression assembly and the first heat exchanger and configured to cool the natural gas stream and the first refrigerant compressed by the plurality of first refrigerant compressors (126a-f) prior to the natural gas stream entering the first heat exchanger, the precooler assembly comprising a plurality of chillers (116a-d) configured to transfer thermal energy from the first refrigerant and the natural gas stream to a second refrigerant; and a second compression assembly fluidly coupled to the precooler assembly and comprising a plurality of second refrigerant compressors (118a-d) configured to compress the second refrigerant and circulate the second refrigerant to the plurality of chillers (116a-d); and a plurality of drivers (120a-d), each driver (120a-d) coupled to at least one of the second refrigerant compressors (118a-d) and configured to drive at least one of the second refrigerant compressors (118a-d); and wherein the first refrigerant is a single mixed refrigerant; characterised in that the plurality of first refrigerant compressors (126a-f) comprises six first refrigerant compressors (126a-f); the plurality of turbines (132a-f) comprises six turbines (132a-f), each turbine (132a-f) being coupled to a respective first refrigerant compressor (126a-f); and at least one turbine is an aeroderivative gas turbine, and at least one other turbine is an industrial gas turbine, wherein the first compression assembly in particular further comprises three intercoolers (136a-c), each intercooler (136a-c) of the three intercoolers (136a-c) fluidly coupling two first refrigerant compressors of the six refrigerant compressors (126a-f). a first heat exchanger configured to receive a natural gas stream from a natural gas source and cool at least a first portion of the natural gas stream to liquefied natural gas; a first compression assembly fluidly coupled to the first heat exchanger and configured to circulate a first refrigerant through the first heat exchanger to cool the first portion of the natural gas stream to the liquefied natural gas, the first compression assembly comprising a plurality of first refrigerant compressors (126a-f) configured to compress the first refrigerant; and a plurality of turbines (132a-f) configured to drive the plurality of first refrigerant compressors (126a-f); a plurality of first refrigerant compressors (126a-f) configured to compress the first refrigerant; and a plurality of turbines (132a-f) configured to drive the plurality of first refrigerant compressors (126a-f); a precooler assembly fluidly coupled to the first compression assembly and the first heat exchanger and configured to cool the natural gas stream and the first refrigerant compressed by the plurality of first refrigerant compressors (126a-f) prior to the natural gas stream entering the first heat exchanger, the precooler assembly comprising a plurality of chillers (116a-d) configured to transfer thermal energy from the first refrigerant and the natural gas stream to a second refrigerant; and a second compression assembly fluidly coupled to the precooler assembly and comprising a plurality of second refrigerant compressors (118a-d) configured to compress the second refrigerant and circulate the second refrigerant to the plurality of chillers (116a-d); and a plurality of drivers (120a-d), each driver (120a-d) coupled to at least one of the second refrigerant compressors (118a-d) and configured to drive at least one of the second refrigerant compressors (118a-d); and a plurality of second refrigerant compressors (118a-d) configured to compress the second refrigerant and circulate the second refrigerant to the plurality of chillers (116a-d); and a plurality of drivers (120a-d), each driver (120a-d) coupled to at least one of the second refrigerant compressors (118a-d) and configured to drive at least one of the second refrigerant compressors (118a-d); and wherein the first refrigerant is a single mixed refrigerant; characterised in that the plurality of first refrigerant compressors (126a-f) comprises six first refrigerant compressors (126a-f); the plurality of turbines (132a-f) comprises six turbines (132a-f), each turbine (132a-f) being coupled to a respective first refrigerant compressor (126a-f); and at least one turbine is an aeroderivative gas turbine, and at least one other turbine is an industrial gas turbine, wherein the first compression assembly in particular further comprises three intercoolers (136a-c), each intercooler (136a-c) of the three intercoolers (136a-c) fluidly coupling two first refrigerant compressors of the six refrigerant compressors (126a-f).