A catheter procedure system comprising: a bedside system comprising a guide wire (58, 402), a guide wire advance/retract actuator coupled to the guide wire (58, 402) and a guide wire rotate actuator coupled to the guide wire (58, 402); and a workstation coupled to the bedside system, the workstation comprising: a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire (58, 402) through a path using the guide wire advance/retract actuator; determine if the guide wire (58, 402) is in a desired path based at least on at least one image of a region of interest; rotate the guide wire (58, 402) using the guide wire rotate actuator if the guide wire (58, 402) is not in the desired path, wherein the guide wire (58, 402) is rotated a predetermined amount; retract the guide wire (58, 402) using the guide wire advance/retract actuator, wherein retracting the guide wire (58, 402) occurs while the guide wire (58, 402) is rotated; repeat the steps of advancing the guide wire (58, 402) and retracting and rotating the guide wire (58, 402) using the guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire (58, 402) is in the desired path; and advance the guide wire (58, 402) to a desired position using the guide wire advance/retract actuator. a bedside system comprising a guide wire (58, 402), a guide wire advance/retract actuator coupled to the guide wire (58, 402) and a guide wire rotate actuator coupled to the guide wire (58, 402); and a workstation coupled to the bedside system, the workstation comprising: a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire (58, 402) through a path using the guide wire advance/retract actuator; determine if the guide wire (58, 402) is in a desired path based at least on at least one image of a region of interest; rotate the guide wire (58, 402) using the guide wire rotate actuator if the guide wire (58, 402) is not in the desired path, wherein the guide wire (58, 402) is rotated a predetermined amount; retract the guide wire (58, 402) using the guide wire advance/retract actuator, wherein retracting the guide wire (58, 402) occurs while the guide wire (58, 402) is rotated; repeat the steps of advancing the guide wire (58, 402) and retracting and rotating the guide wire (58, 402) using the guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire (58, 402) is in the desired path; and advance the guide wire (58, 402) to a desired position using the guide wire advance/retract actuator. a user interface; at least one display (26, 28); a controller coupled to the bedside system, the user interface and the at least one display (26, 28), the controller programmed to: advance the guide wire (58, 402) through a path using the guide wire advance/retract actuator; determine if the guide wire (58, 402) is in a desired path based at least on at least one image of a region of interest; rotate the guide wire (58, 402) using the guide wire rotate actuator if the guide wire (58, 402) is not in the desired path, wherein the guide wire (58, 402) is rotated a predetermined amount; retract the guide wire (58, 402) using the guide wire advance/retract actuator, wherein retracting the guide wire (58, 402) occurs while the guide wire (58, 402) is rotated; repeat the steps of advancing the guide wire (58, 402) and retracting and rotating the guide wire (58, 402) using the guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire (58, 402) is in the desired path; and advance the guide wire (58, 402) to a desired position using the guide wire advance/retract actuator. advance the guide wire (58, 402) through a path using the guide wire advance/retract actuator; determine if the guide wire (58, 402) is in a desired path based at least on at least one image of a region of interest; rotate the guide wire (58, 402) using the guide wire rotate actuator if the guide wire (58, 402) is not in the desired path, wherein the guide wire (58, 402) is rotated a predetermined amount; retract the guide wire (58, 402) using the guide wire advance/retract actuator, wherein retracting the guide wire (58, 402) occurs while the guide wire (58, 402) is rotated; repeat the steps of advancing the guide wire (58, 402) and retracting and rotating the guide wire (58, 402) using the guide wire advance/retract actuator and the guide wire rotate actuator until the guide wire (58, 402) is in the desired path; and advance the guide wire (58, 402) to a desired position using the guide wire advance/retract actuator.