A peripheral catheter (114;214;314;414), comprising: a tubular body member of a predetermined diameter and wall thickness, the tubular body member having a proximal end, a distal end and a lumen (380;490) extending therebetween, the tubular body member further having a truncated length sufficient to access a peripheral vein of a patient; a plurality of holes (250;350;450) positioned on the tapered tip (146;340;440) of the tubular body member, the plurality of holes (250;350;450) being formed through the wall thickness of the tubular body member and in communication with the lumen (380;490) to define an array of diffusion holes (250;350;450;452;454), the lumen (380;490) further includes a first inner wall surface defining a first plane, and each staggered hole (250;350;450) further includes a second inner wall surface defining a second plane, wherein an orientation of the second plane is acute from about 15° to about 75° to an orientation of the first plane, the catheter has an open distal tip opening (142, 242, 342) and the catheter further comprises a first set of holes disposed in a first annular ring, and a second set of holes disposed in a second annular ring, wherein the second set of holes (250;350;450) is axially staggered from the first set of holes from about 15° to about 60° characterized by a tapered tip (146;340;440) forming the distal end of the tubular body member; wherein the tapered tip (146;340;440) is tapered to a diameter that is less than the predetermined diameter of the tubular body member, the tapered tip (146;340;440) further including an opening to the lumen (380;490), wherein a gap is provided between adjacent holes (456,452) of the first set of holes disposed in the first annular ring, wherein the gap accommodates a width of a downstream hole of the second annular ring, such that the downstream hole and the gap are aligned along a common axis. a tubular body member of a predetermined diameter and wall thickness, the tubular body member having a proximal end, a distal end and a lumen (380;490) extending therebetween, the tubular body member further having a truncated length sufficient to access a peripheral vein of a patient; a plurality of holes (250;350;450) positioned on the tapered tip (146;340;440) of the tubular body member, the plurality of holes (250;350;450) being formed through the wall thickness of the tubular body member and in communication with the lumen (380;490) to define an array of diffusion holes (250;350;450;452;454), the lumen (380;490) further includes a first inner wall surface defining a first plane, and each staggered hole (250;350;450) further includes a second inner wall surface defining a second plane, wherein an orientation of the second plane is acute from about 15° to about 75° to an orientation of the first plane, the catheter has an open distal tip opening (142, 242, 342) and the catheter further comprises a first set of holes disposed in a first annular ring, and a second set of holes disposed in a second annular ring, wherein the second set of holes (250;350;450) is axially staggered from the first set of holes from about 15° to about 60° characterized by a tapered tip (146;340;440) forming the distal end of the tubular body member; wherein the tapered tip (146;340;440) is tapered to a diameter that is less than the predetermined diameter of the tubular body member, the tapered tip (146;340;440) further including an opening to the lumen (380;490), wherein a gap is provided between adjacent holes (456,452) of the first set of holes disposed in the first annular ring, wherein the gap accommodates a width of a downstream hole of the second annular ring, such that the downstream hole and the gap are aligned along a common axis.