A method for detecting a single nucleotide polymorphism in a target nucleic acid in a sample, the method comprising: - performing an amplifying step comprising contacting the sample with a primer comprising a first nucleic acid sequence to produce an amplification product if any target nucleic acid is present in the sample; - performing a hybridizing step comprising contacting the amplification product with a SNP specific hydrolysis probe having a 5' end and a 3' end, said SNP specific hydrolysis probe having a nucleic acid sequence consisting of a hairpin structure towards the 3' end and a second nucleic acid sequence complementary to a SNP containing region of the amplification product; said SNP specific hydrolysis probe further comprising a first and a second interactive label, wherein said first interactive label comprises a donor fluorescent moiety at the 5' terminus, and said second interactive label comprises a corresponding acceptor fluorescent moiety within no more than 5 nucleotides of the donor fluorescent moiety on the hydrolysis probe and wherein the nucleotide within the second nucleic acid sequence of the hydrolysis probe hybridizing to the SNP in the amplification product is positioned between the first and second interactive label; and said hairpin structure comprising a region of non-naturally occurring nucleic acid sequence comprising one or more non-naturally occurring nucleotides to produce the hairpin structure at the 3' end and wherein said one or more non-naturally occurring nucleotides are added or changed nucleotides at the 3' end of the hydrolysis probe compared to the natural or wild type sequence of the amplification product; and - detecting the presence or absence of the amplification product, wherein the presence of the amplification products is indicative of the presence of the SNP in the nucleic acid target, and wherein the absence of the amplification products is indicative of the absence of the SNP in the nucleic acid target. - performing an amplifying step comprising contacting the sample with a primer comprising a first nucleic acid sequence to produce an amplification product if any target nucleic acid is present in the sample; - performing a hybridizing step comprising contacting the amplification product with a SNP specific hydrolysis probe having a 5' end and a 3' end, said SNP specific hydrolysis probe having a nucleic acid sequence consisting of a hairpin structure towards the 3' end and a second nucleic acid sequence complementary to a SNP containing region of the amplification product; said SNP specific hydrolysis probe further comprising a first and a second interactive label, wherein said first interactive label comprises a donor fluorescent moiety at the 5' terminus, and said second interactive label comprises a corresponding acceptor fluorescent moiety within no more than 5 nucleotides of the donor fluorescent moiety on the hydrolysis probe and wherein the nucleotide within the second nucleic acid sequence of the hydrolysis probe hybridizing to the SNP in the amplification product is positioned between the first and second interactive label; and said hairpin structure comprising a region of non-naturally occurring nucleic acid sequence comprising one or more non-naturally occurring nucleotides to produce the hairpin structure at the 3' end and wherein said one or more non-naturally occurring nucleotides are added or changed nucleotides at the 3' end of the hydrolysis probe compared to the natural or wild type sequence of the amplification product; and - detecting the presence or absence of the amplification product, wherein the presence of the amplification products is indicative of the presence of the SNP in the nucleic acid target, and wherein the absence of the amplification products is indicative of the absence of the SNP in the nucleic acid target.