mhurhangee/ep-ind-claims huggingface dataset:
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[ -2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide (velusetrag) or a pharmaceutically-acceptable salt thereof for use in a method of preventing, alleviating, ameliorating, giving relief to, treating one or more of the core symptoms of gastroparesis consisting of postprandial fullness, early satiety, bloating, upper abdominal pain, epigastric burning, nausea and vomiting in diabetic or idiopathic human patient, wherein velusetrag is administered in a dosage of 0.5 mg/day to 5 mg/day, for a treatment period of one week, two, four, eight, twelve weeks or longer.
A brake caliper for a disc brake assembly featuring at least one caliper bridge extending in the axial direction and having a pad inspection opening provided therein, characterized in that the pad inspection opening is at least partially precisely closed by a brake dust particle filter which is designed to at least partially precisely close the pad inspection opening in an assembled state.
A method for producing an instant drink mixture, in particular for an instant drink containing coffee and/or a coffee drink, wherein the method comprises the following method steps: (a) providing at least one coffee extract, in particular in the form of an aqueous fluid extract; (b) subsequent concentrating of the coffee extract to obtain a thickened coffee extract (thick extract); (c) then cooling the thickened coffee extract obtained in method step (b) to temperatures below 0°C such that the cooled, thickened coffee extract has an increased viscosity and/or reduced flowability compared with the coffee extract obtained from (b); and (d) including and/or incorporating roasted coffee powder into the cooled, thickened coffee extract subsequently and/or during method step (c), in particular subsequently, by means of mixing and/or stirring the roasted coffee to obtain a homogeneous and/or uniform distribution of the roasted coffee in the cooled coffee extract or in the cooled, thickened coffee extract, wherein in method step (a) and/or (b) the coffee extract is adjusted to a solids content in the range of 20 to 75 wt%, relative to the coffee extract, and wherein in method step (c) the cooled coffee extract is adjusted to a dynamic viscosity in the range of 200 to 10,000 mPa·s in relation to a temperature in the range of -10°C to 10°C. (a) providing at least one coffee extract, in particular in the form of an aqueous fluid extract; (b) subsequent concentrating of the coffee extract to obtain a thickened coffee extract (thick extract); (c) then cooling the thickened coffee extract obtained in method step (b) to temperatures below 0°C such that the cooled, thickened coffee extract has an increased viscosity and/or reduced flowability compared with the coffee extract obtained from (b); and (d) including and/or incorporating roasted coffee powder into the cooled, thickened coffee extract subsequently and/or during method step (c), in particular subsequently, by means of mixing and/or stirring the roasted coffee to obtain a homogeneous and/or uniform distribution of the roasted coffee in the cooled coffee extract or in the cooled, thickened coffee extract,
A method for determining the position of a terminal device using two or more positioning methods, wherein a positioning method selection device (PMSD) is provided in the terminal device for managing the use of said two or more positioning methods by one or more application program (201, 202) executable by the terminal device, characterized in that the positioning method selection device receives positioning data from said two or more positioning methods, in that the positioning method selection device determines whether the positioning data received from said two or more positioning methods fulfills a quality requirement received from a particular one of said one or more application program and in that the positioning method selection device provides positioning data fulfilling said quality requirement to said particular one of said one or more application program.
A fluid supply pipe comprising an internal structure and a pipe body configured to house the internal structure, the pipe body having an inlet and an outlet, wherein the internal structure comprises: a first internal structure (20, 200, 210, 220, 230, 240, 250, 1200); and a second internal structure (30, 300, 310, 320, 330, 340, 350, 1300), and that the first internal structure comprises: a head portion (22, 1022) comprising a plurality of spiral vanes; and a body portion (24, 1024) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, characterised in that the second internal structure is formed in a hollow shaft shape comprising: a head portion (31, 1031) comprising a plurality of spiral vanes; and a body portion (33, 1033) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, and that at least a part of the first internal structure is housed in the hollow of the second internal structure. a first internal structure (20, 200, 210, 220, 230, 240, 250, 1200); and a second internal structure (30, 300, 310, 320, 330, 340, 350, 1300), and that the first internal structure comprises: a head portion (22, 1022) comprising a plurality of spiral vanes; and a body portion (24, 1024) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, characterised in that the second internal structure is formed in a hollow shaft shape comprising: a head portion (31, 1031) comprising a plurality of spiral vanes; and a body portion (33, 1033) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, a head portion (22, 1022) comprising a plurality of spiral vanes; and a body portion (24, 1024) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, characterised in that the second internal structure is formed in a hollow shaft shape comprising: a head portion (31, 1031) comprising a plurality of spiral vanes; and a body portion (33, 1033) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, a head portion (31, 1031) comprising a plurality of spiral vanes; and a body portion (33, 1033) positioned downstream from the head portion and comprising a plurality of protrusions on its outer circumferential surface, and that at least a part of the first internal structure is housed in the hollow of the second internal structure.
A valve for a positive displacement pump, the valve comprising a valve body and a valve seat each having engagement surfaces (460a; 461a) which are configured, in use, to at least partially engage with one another when the valve is in a closed position to thereby mitigate fluid flow therethrough, the valve body being movable, in use, relative to the valve seat along a linear path of motion from the closed position to an open position, wherein, when the valve is in the open position, i) at least a peripheral portion of the engagement surface of the valve body extends at an obtuse angle relative to the linear path of motion in the direction of motion from the closed position to the open position and wherein the radial length of the peripheral portion is at least 13% of the length of the engagement surface, ii) an inner portion of the engagement surface of the valve body extends at an acute angle relative to the linear path of motion in the direction of motion from the closed position to the open position, and iii) at least a peripheral portion of the engagement surface of the valve seat extends perpendicularly or at an obtuse angle relative to the linear path of motion in the direction of motion from the closed position to the open position.
An antibody composition comprising a plurality of antibodies comprising a functionalized acceptor glutamine residue flanked at the +2 position by a non-aspartic acid residue and sharing the same heavy and/or light chain amino acid sequence, wherein at least 90% of the antibodies in said composition have at least m functionalized acceptor glutamine residues per antibody, wherein m is 2 or 4, the functionalized acceptor glutamine residue having Formula IVb, -NH- n -X-L-(V-(Y- z) q) r Formula IVb or a pharmaceutically acceptable salt or solvate thereof, wherein: Q is a glutamine residue present in an antibody or antibody fragment in position 295 or 297 of the heavy chain (EU index numbering); n is a substituted or unsubstituted alkyl or heteroalkyl chain, with the substituent being selected from alkoxy, hydroxyl, alkylcarbonyloxy, alkyl-S-, thiol, alkyl-C S-, amine, alkylamine, amide, and alkylamide; n, the length of the carbon chain, is an integer selected from among the range of 2 to 20; X is NH, O, S, absent, or a bond; L is independently absent, a bond or a carbon comprising framework of 1 to 200 atoms substituted at one or more atoms; r is an integer selected from among 1, 2, 3 or 4; q is an integer selected from among 1, 2, 3 or 4; z is an integer selected from among 1, 2, 3 or 4; V is independently absent, a bond, a non-cleavable moiety or a conditionally-cleavable moiety; Y is independently absent, a bond, or a spacer system which is comprised of 1 or more spacers; M is R, wherein R is a reactive moiety chosen to undergo a Staudinger ligation; a Huisgen 1,3-cycloaddition (click reaction); or a Diels-Alder cycloaddition. Q is a glutamine residue present in an antibody or antibody fragment in position 295 or 297 of the heavy chain (EU index numbering); n is a substituted or unsubstituted alkyl or heteroalkyl chain, with the substituent being selected from alkoxy, hydroxyl, alkylcarbonyloxy, alkyl-S-, thiol, alkyl-C S-, amine, alkylamine, amide, and alkylamide; n, the length of the carbon chain, is an integer selected from among the range of 2 to 20; X is NH, O, S, absent, or a bond; L is independently absent, a bond or a carbon comprising framework of 1 to 200 atoms substituted at one or more atoms; r is an integer selected from among 1, 2, 3 or 4; q is an integer selected from among 1, 2, 3 or 4; z is an integer selected from among 1, 2, 3 or 4; V is independently absent, a bond, a non-cleavable moiety or a conditionally-cleavable moiety; Y is independently absent, a bond, or a spacer system which is comprised of 1 or more spacers; M is R, wherein R is a reactive moiety chosen to undergo a Staudinger ligation; a Huisgen 1,3-cycloaddition (click reaction); or a Diels-Alder cycloaddition.
Method of manufacturing a connection assembly using the tool of any of the claims 7 to 14, said method plastically deforming a connection device about a conductor and thus moving two faces of the connection device into a position adjacent to each other, and by materially bonding the two adjacent faces to each other using electric current, characterized in that the current runs from a first electrode on a deformation part of a deformation unit to a second electrode on the same deformation part, wherein the first electrode and the second electrode are separated by an insulating part.
Humidity sensor of the capacitive type comprising, on a support: - a first electrode lying on the support, - a region of dielectric material disposed between said first electrode and a second electrode, the second electrode being formed by a layer based on a conductive material having a permeability to moisture greater to that of said region of dielectric material with which it is contact, said layer based on a conductive material being based on graphene, the first electrode, the region of dielectric material and the second electrode forming a moisture-dependent variable capacitance in the vicinity of an interface between the second electrode and the dielectric region. - a first electrode lying on the support, - a region of dielectric material disposed between said first electrode and a second electrode, the second electrode being formed by a layer based on a conductive material having a permeability to moisture greater to that of said region of dielectric material with which it is contact,
A coupling for transferring fluids, having a housing and a nipple which can be fixed thereon, which can be separated from the housing when a predetermined axial tensile force is exceeded while overcoming a spring force, and having a fluid channel which passes through the housing and the nipple, in the course of which a housing-side and a nipple-side non-return valve (21, 31) are arranged, and which is guided in a radially directed manner around a vented cylindrical interior of the nipple, characterized in that in this coupling a closure mechanism comprises a housing-side pin and a nipple-side pin, and a sleeve arranged between said pins, which is arranged in an axially movable manner in the interior of the nipple, and can be locked by means of spring-pressure-mounted locking elements with the housing-side pin, such that when the nipple is fixed the non-return valves (21, 31) are held open against their spring force, and when the nipple is released the housing-side non-return valve is completely closed and the nipple-side non-return valve is at least partially closed, and in which the sleeve engages around a housing-side piston, and via the locking elements can be fixed thereto and can be separated therefrom against the spring force, and the housing-side pin is guided in an axially movable manner in the piston, and is supported in an open state of the housing-side non-retrun valve against the locking elements.
A method for reclaiming active material from a galvanic cell that comprises an active material, a carrier for the active material and a binder for binding the active material and the carrier, said method comprising the steps: (a) comminuting the cells, in particular under inert gas or in a vacuum, such that solid cell fragments are at least also produced, (b) heating the solid cell fragments to a decomposition temperature (Tz) selected to be high enough that the binder decomposes and/or evaporates, preferably under inert gas or in a vacuum, so as to produce thermally treated cell fragments, and (c) classification of these thermally treated cell fragments, characterised by the fact that (d) the classification comprises an air-jet sieving process, (e) the air-jet sieving process is implemented such that active material is separated from the carrier. (a) comminuting the cells, in particular under inert gas or in a vacuum, such that solid cell fragments are at least also produced, (b) heating the solid cell fragments to a decomposition temperature (Tz) selected to be high enough that the binder decomposes and/or evaporates, preferably under inert gas or in a vacuum, so as to produce thermally treated cell fragments, and (c) classification of these thermally treated cell fragments, characterised by the fact that (d) the classification comprises an air-jet sieving process, (e) the air-jet sieving process is implemented such that active material is separated from the carrier.
Device for depositing dough, comprising: - A supply conveyor for a dough sheet, guided over a path, said path comprising a nose bar that is translatable over a first distance; characterised in that, - A transmission (6,7,8,9,10), for translating the nose bar, the transmission (6,7,8,9,10) comprising a rod, o rotatably coupled to a first rotatable arm at a first coupling point on the rod; o rotatably coupled to a second rotatable arm at a second coupling point on the rod, o rotatably coupled to the nose bar at a third coupling point on the rod, wherein o the second coupling point is at a second distance from the first coupling point; o the third coupling point being at a third distance from the first coupling point; and o the third distance is larger than the second distance; and - A drive, for driving at least one of the first and/or the second rotatable arms (7,9), wherein by driving at least one of the first or second rotatable arm (7,9), the rod is moved, and therewith the nose bar of the device, wherein the length of the first arm, the length of the second arm and the distance between the rotation point of the first arm and the second arm relate as 2:5:4, and wherein the rod is twice as long as the second arm, and the second arm is coupled to the rod halfway to the rods length. - A supply conveyor for a dough sheet, guided over a path, said path comprising a nose bar that is translatable over a first distance; characterised in that, - A transmission (6,7,8,9,10), for translating the nose bar, the transmission (6,7,8,9,10) comprising a rod, o rotatably coupled to a first rotatable arm at a first coupling point on the rod; o rotatably coupled to a second rotatable arm at a second coupling point on the rod, o rotatably coupled to the nose bar at a third coupling point on the rod, wherein o the second coupling point is at a second distance from the first coupling point; o the third coupling point being at a third distance from the first coupling point; and o the third distance is larger than the second distance; and o rotatably coupled to a first rotatable arm at a first coupling point on the rod; o rotatably coupled to a second rotatable arm at a second coupling point on the rod, o rotatably coupled to the nose bar at a third coupling point on the rod, o the second coupling point is at a second distance from the first coupling point; o the third coupling point being at a third distance from the first coupling point; and o the third distance is larger than the second distance; and - A drive, for driving at least one of the first and/or the second rotatable arms (7,9),
A vehicle with a fairing and a sliding door that is glidingly mounted to the vehicle, wherein the sliding door is associated with a foldable fairing integrated footstep unit, and wherein the foldable fairing integrated footstep unit comprises: an outer shell that is integrated into the fairing of the vehicle, the outer shell comprising an exterior surface that creates in closed state of the foldable fairing integrated footstep unit an at least approximately continuous aerodynamic surface with the fairing, wherein an unfolding/folding unit (11, 12, 13, 14) connects the outer shell to the vehicle, the unfolding / folding unit (11, 12, 13, 14) comprising: a sliding mechanism that is adapted for being engaged by the sliding door at least during an opening gliding movement and a closing gliding movement of the sliding door, and a guiding link that connects the outer shell to the sliding mechanism; the unfolding / folding unit (11, 12, 13, 14) being provided for unfolding the foldable fairing integrated footstep unit into an opened state during the opening gliding movement of the sliding door and for folding the foldable fairing integrated footstep unit into the closed state during the closing gliding movement of the sliding door. an outer shell that is integrated into the fairing of the vehicle, the outer shell comprising an exterior surface that creates in closed state of the foldable fairing integrated footstep unit an at least approximately continuous aerodynamic surface with the fairing, wherein an unfolding/folding unit (11, 12, 13, 14) connects the outer shell to the vehicle, the unfolding / folding unit (11, 12, 13, 14) comprising: a sliding mechanism that is adapted for being engaged by the sliding door at least during an opening gliding movement and a closing gliding movement of the sliding door, and a guiding link that connects the outer shell to the sliding mechanism; the unfolding / folding unit (11, 12, 13, 14) being provided for unfolding the foldable fairing integrated footstep unit into an opened state during the opening gliding movement of the sliding door and for folding the foldable fairing integrated footstep unit into the closed state during the closing gliding movement of the sliding door. a sliding mechanism that is adapted for being engaged by the sliding door at least during an opening gliding movement and a closing gliding movement of the sliding door, and a guiding link that connects the outer shell to the sliding mechanism; the unfolding / folding unit (11, 12, 13, 14) being provided for unfolding the foldable fairing integrated footstep unit into an opened state during the opening gliding movement of the sliding door and for folding the foldable fairing integrated footstep unit into the closed state during the closing gliding movement of the sliding door.
A burner head for a fuel manifold, the burner head comprising: a mains fuel injector; a pilot fuel injector; a fuel source; a first isolation valve (60, 94) connected to the fuel source; a staging valve, the staging valve being connected to the first isolation valve (60, 94), and the staging valve having a mains fuel conduit connected to the mains fuel injector and a pilot fuel conduit connected to the pilot fuel injector; and a second isolation valve, the second isolation valve being in series between the first isolation valve and the mains fuel conduit of the staging valve; wherein the first isolation valve (60, 94) and the staging valve are connected in series, such that fuel from the fuel source must pass through the first isolation valve (60, 94) before arriving at the staging valve; the burner head being characterised in that the force required to open the first isolation valve is different to the force required to open the second isolation valve. a mains fuel injector; a pilot fuel injector; a fuel source; a first isolation valve (60, 94) connected to the fuel source; a staging valve, the staging valve being connected to the first isolation valve (60, 94), and the staging valve having a mains fuel conduit connected to the mains fuel injector and a pilot fuel conduit connected to the pilot fuel injector; and a second isolation valve, the second isolation valve being in series between the first isolation valve and the mains fuel conduit of the staging valve; wherein the first isolation valve (60, 94) and the staging valve are connected in series, such that fuel from the fuel source must pass through the first isolation valve (60, 94) before arriving at the staging valve; the burner head being characterised in that the force required to open the first isolation valve is different to the force required to open the second isolation valve.
A winching system for winching a load, which is provided with a winch and with a suspension element, said suspension element extending from a fixed end which cooperates with said winch to a free end capable of being connected to said load, said winching system having an additional means for positioning said free end which is located directly above the free end, characterised in that, said winching system having a distinct main severing means and a distinct backup severing means for severing said suspension element, said main severing means is fastened to the winch, said backup severing means being fastened immovably without a tool to said additional means.