A medical device, comprising: an elongate support structure (110, 150); and an inflatable balloon, the balloon comprising a first-end portion secured to the support structure (110, 150) at a first location, a second-end portion secured to the support structure (110, 150) at a second location distal to the first location, and a middle-body portion, the middle-body portion having a first end integrally formed with or otherwise bonded to the first-end portion, and a second end integrally formed with or otherwise bonded to the second-end portion, the first-end portion having a wall thickness greater than a wall thickness of the middle-body portion, the respective first-end portion, middle-body portion and second-end portion collectively defining a sealed interior of the balloon through which the support structure (110, 150) extends, characterized in that the balloon is stretch-mounted to the support structure (110, 150) so as to be in tension relative to the support structure (110, 150), wherein the balloon has a diamond-shaped configuration when the interior of the balloon is inflated to an inflation pressure that is equal or similar to the atmospheric pressure, and wherein the balloon transitions to a substantially spherical configuration when the balloon is inflated to an inflation pressure that is at least about ten percent greater than atmospheric pressure external to the balloon, such that the balloon, when inflated to the inflation pressure that is at least about ten percent greater than atmospheric pressure external to the balloon and anchored in an anatomical body region, resists movement of the support structure (110, 150) relative to the balloon. an elongate support structure (110, 150); and an inflatable balloon, the balloon comprising a first-end portion secured to the support structure (110, 150) at a first location, a second-end portion secured to the support structure (110, 150) at a second location distal to the first location, and a middle-body portion, the middle-body portion having a first end integrally formed with or otherwise bonded to the first-end portion, and a second end integrally formed with or otherwise bonded to the second-end portion, the first-end portion having a wall thickness greater than a wall thickness of the middle-body portion, the respective first-end portion, middle-body portion and second-end portion collectively defining a sealed interior of the balloon through which the support structure (110, 150) extends, characterized in that the balloon is stretch-mounted to the support structure (110, 150) so as to be in tension relative to the support structure (110, 150), wherein the balloon has a diamond-shaped configuration when the interior of the balloon is inflated to an inflation pressure that is equal or similar to the atmospheric pressure, and wherein the balloon transitions to a substantially spherical configuration when the balloon is inflated to an inflation pressure that is at least about ten percent greater than atmospheric pressure external to the balloon, such that the balloon, when inflated to the inflation pressure that is at least about ten percent greater than atmospheric pressure external to the balloon and anchored in an anatomical body region, resists movement of the support structure (110, 150) relative to the balloon.