An intracranial pressure monitoring device, comprising: a housing defining a first internal chamber, the first internal chamber being hermetically sealed and having controlled contents to produce a reference pressure in the chamber; a plurality of strain gauges disposed on an inner surface of a diaphragm defined by a wall of the first internal chamber; a device for generating orientation signals for determining an orientation of the intracranial monitoring device relative to a vertical direction; and circuitry coupled to the plurality of strain gauges and to the device for generating orientation signals, the circuitry configured to: generate pressure waveform data based on signals received from the plurality of strain gauges, wherein the degree of deformation of the diaphragm is measured against the reference pressure in order to correlate to an external pressure experienced by the diaphragm generate orientation data at a patient head that affects a measured intracranial pressure, based on the orientation signals received from the device for generating orientation signals; store the pressure waveform data and the orientation data in a computer readable storage such that the pressure waveform data and orientation data are associated with each other; calculate a calculated intracranial pressure value for each of a plurality of positions based on stored pressure waveform data and record the calculated intracranial pressure value with the orientation data; and compare the calculated intracranial pressure value to a measured intracranial pressure value to determine if the intracranial monitoring device has been calibrated. a housing defining a first internal chamber, the first internal chamber being hermetically sealed and having controlled contents to produce a reference pressure in the chamber; a plurality of strain gauges disposed on an inner surface of a diaphragm defined by a wall of the first internal chamber; a device for generating orientation signals for determining an orientation of the intracranial monitoring device relative to a vertical direction; and circuitry coupled to the plurality of strain gauges and to the device for generating orientation signals, the circuitry configured to: generate pressure waveform data based on signals received from the plurality of strain gauges, wherein the degree of deformation of the diaphragm is measured against the reference pressure in order to correlate to an external pressure experienced by the diaphragm generate orientation data at a patient head that affects a measured intracranial pressure, based on the orientation signals received from the device for generating orientation signals; store the pressure waveform data and the orientation data in a computer readable storage such that the pressure waveform data and orientation data are associated with each other; calculate a calculated intracranial pressure value for each of a plurality of positions based on stored pressure waveform data and record the calculated intracranial pressure value with the orientation data; and compare the calculated intracranial pressure value to a measured intracranial pressure value to determine if the intracranial monitoring device has been calibrated. generate pressure waveform data based on signals received from the plurality of strain gauges, wherein the degree of deformation of the diaphragm is measured against the reference pressure in order to correlate to an external pressure experienced by the diaphragm generate orientation data at a patient head that affects a measured intracranial pressure, based on the orientation signals received from the device for generating orientation signals; store the pressure waveform data and the orientation data in a computer readable storage such that the pressure waveform data and orientation data are associated with each other; calculate a calculated intracranial pressure value for each of a plurality of positions based on stored pressure waveform data and record the calculated intracranial pressure value with the orientation data; and compare the calculated intracranial pressure value to a measured intracranial pressure value to determine if the intracranial monitoring device has been calibrated.