A system (100, 600) for delivering neurostimulation to tissue of a patient using a plurality of electrodes (106, 206-1-N, 207, 406, 506, 606, 706, 707) and controlling the delivery of the neurostimulation by a user, the system comprising: a programming control circuit (316, 816) configured to generate a plurality of stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration, the neurostimulation delivered through one or more electrodes of the plurality of electrodes; and a stimulation control circuit (320, 920) configured to specify the stimulation configuration, the stimulation control circuit including: volume definition circuitry configured to determine test volumes each corresponding to a stimulation configuration, to determine one or more clinical effects each resulting from the determined test volumes being activated by the neurostimulation, to generate a recommended volume based on the determined test volumes, the determined one or more clinical effects, and at least one of a floor or a target magnitude specified for the one or more clinical effects, and to determine a target volume based on at least the determined test volumes and the recommended volume, the test volumes, the recommended volume, and the target volume each representing a portion of the tissue; and stimulation configuration circuitry configured to generate the specified stimulation configuration for activating a stimulation volume substantially matching the target volume. a programming control circuit (316, 816) configured to generate a plurality of stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration, the neurostimulation delivered through one or more electrodes of the plurality of electrodes; and a stimulation control circuit (320, 920) configured to specify the stimulation configuration, the stimulation control circuit including: volume definition circuitry configured to determine test volumes each corresponding to a stimulation configuration, to determine one or more clinical effects each resulting from the determined test volumes being activated by the neurostimulation, to generate a recommended volume based on the determined test volumes, the determined one or more clinical effects, and at least one of a floor or a target magnitude specified for the one or more clinical effects, and to determine a target volume based on at least the determined test volumes and the recommended volume, the test volumes, the recommended volume, and the target volume each representing a portion of the tissue; and stimulation configuration circuitry configured to generate the specified stimulation configuration for activating a stimulation volume substantially matching the target volume. volume definition circuitry configured to determine test volumes each corresponding to a stimulation configuration, to determine one or more clinical effects each resulting from the determined test volumes being activated by the neurostimulation, to generate a recommended volume based on the determined test volumes, the determined one or more clinical effects, and at least one of a floor or a target magnitude specified for the one or more clinical effects, and to determine a target volume based on at least the determined test volumes and the recommended volume, the test volumes, the recommended volume, and the target volume each representing a portion of the tissue; and stimulation configuration circuitry configured to generate the specified stimulation configuration for activating a stimulation volume substantially matching the target volume.