mhurhangee/ep-ind-claims huggingface dataset:
A method of making an antibody drug conjugate, comprising contacting a synthon according to structural formula D-L-R x, or a pharmaceutically acceptable salt thereof, wherein: D is a drug; L is a linker; and R x is a moiety comprising a functional group capable of covalently linking the synthon to an antibody, and further wherein drug D is a Bcl-xL inhibitor according to structural formula: or pharmaceutically acceptable salts thereof, wherein: Ar is selected from which is optionally substituted with one or more substituents independently selected from halo, cyano, methyl, and halomethyl; Z 1 is selected from N, CH and C-CN; Z 2 is selected from NH, CH 2, O, S, S, and S(O 2); R 1 is selected from methyl, chloro, and cyano; R 2 is selected from hydrogen, methyl, chloro, and cyano; R 4 is hydrogen, C 1-4 alkanyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl or C 1-4 hydroxyalkyl, wherein the R 4 C 1-4 alkanyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl and C 1-4 hydroxyalkyl are optionally substituted with one or more substituents independently selected from OCH 3, OCH 2 CH 2 OCH 3, and OCH 2 CH 2 NHCH 3; R 10a, R 10b, and R 10c are each, independently of one another, selected from hydrogen, halo, C 1-6 alkanyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-6 haloalkyl; R 11a and R 11b are each, independently of one another, selected from hydrogen, methyl, ethyl, halomethyl, hydroxyl, methoxy, halo, CN and SCH 3; n is 0, 1, 2 or 3; and # represents the point of attachment to linker L; under conditions in which the synthon covalently links to an antibody. D is a drug; L is a linker; and R x is a moiety comprising a functional group capable of covalently linking the synthon to an antibody, and further wherein drug D is a Bcl-xL inhibitor according to structural formula: Ar is selected from which is optionally substituted with one or more substituents independently selected from halo, cyano, methyl, and halomethyl; Z 1 is selected from N, CH and C-CN; Z 2 is selected from NH, CH 2, O, S, S, and S(O 2); R 1 is selected from methyl, chloro, and cyano; R 2 is selected from hydrogen, methyl, chloro, and cyano; R 4 is hydrogen, C 1-4 alkanyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl or C 1-4 hydroxyalkyl, wherein the R 4 C 1-4 alkanyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl and C 1-4 hydroxyalkyl are optionally substituted with one or more substituents independently selected from OCH 3, OCH 2 CH 2 OCH 3, and OCH 2 CH 2 NHCH 3; R 10a, R 10b, and R 10c are each, independently of one another, selected from hydrogen, halo, C 1-6 alkanyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-6 haloalkyl; R 11a and R 11b are each, independently of one another, selected from hydrogen, methyl, ethyl, halomethyl, hydroxyl, methoxy, halo, CN and SCH 3; n is 0, 1, 2 or 3; and # represents the point of attachment to linker L;
An implantable knee unloading device for a knee comprising: a first member configured to be affixed to a first member of a knee joint; a second member configured to be affixed to a second member of the knee joint; mating portions (130, 140) of the first and second members (104, 108) configured to contact one another to transmit force between the first and second members (104, 108), wherein the mating portions (130, 140) are not connected to one another; and wherein the knee unloading device is configured to be implanted outside of the joint capsule and to absorb at least a portion of the total load applied to the knee during at least 5 degrees and during no more than 90 degrees of a natural range of motion of the knee, characterised in that the mating portions (130, 140) of the first and second members (104, 108) are substantially cone shaped. a first member configured to be affixed to a first member of a knee joint; a second member configured to be affixed to a second member of the knee joint; mating portions (130, 140) of the first and second members (104, 108) configured to contact one another to transmit force between the first and second members (104, 108), wherein the mating portions (130, 140) are not connected to one another; and wherein the knee unloading device is configured to be implanted outside of the joint capsule and to absorb at least a portion of the total load applied to the knee during at least 5 degrees and during no more than 90 degrees of a natural range of motion of the knee, characterised in that the mating portions (130, 140) of the first and second members (104, 108) are substantially cone shaped.
A method for managing energy efficiency in a computing system comprising a plurality of clusters, the method comprising: detecting an event in which a current operating frequency of an active cluster of the clusters enters or crosses any of one or more predetermined frequency spots (sweet-spot frequency ranges) of the active cluster, wherein a frequency spot represents a boundary area for the peak performance frequency range of the active cluster and a boundary area for the peak performance frequency range of a target cluster, wherein the active cluster further includes one or more first processor cores; and when the event is detected, performing following steps: identifying the target cluster of the clusters including one or more second processor cores, wherein each first processor core in the active cluster and each second processor core in the target cluster have different energy efficiency characteristics; activating at least one second processor core in the target cluster; determining whether to migrate one or more interrupt requests from the active cluster to the target cluster; and determining whether to deactivate at least one first processor core of the active cluster based on a performance and power requirement. detecting an event in which a current operating frequency of an active cluster of the clusters enters or crosses any of one or more predetermined frequency spots (sweet-spot frequency ranges) of the active cluster, wherein a frequency spot represents a boundary area for the peak performance frequency range of the active cluster and a boundary area for the peak performance frequency range of a target cluster, wherein the active cluster further includes one or more first processor cores; and when the event is detected, performing following steps: identifying the target cluster of the clusters including one or more second processor cores, wherein each first processor core in the active cluster and each second processor core in the target cluster have different energy efficiency characteristics; activating at least one second processor core in the target cluster; determining whether to migrate one or more interrupt requests from the active cluster to the target cluster; and determining whether to deactivate at least one first processor core of the active cluster based on a performance and power requirement. identifying the target cluster of the clusters including one or more second processor cores, wherein each first processor core in the active cluster and each second processor core in the target cluster have different energy efficiency characteristics; activating at least one second processor core in the target cluster; determining whether to migrate one or more interrupt requests from the active cluster to the target cluster; and determining whether to deactivate at least one first processor core of the active cluster based on a performance and power requirement.
An encoder apparatus for determining the position of a first object relative to a second object, comprising a measuring standard connected to the first object and having at least one position segment with a plurality of incremental code elements, a first incremental scanning device connected to the second object and having at least two individual scanning units in mutual phase offset for generating a respective scanning signal by scanning the measuring standard, the duty cycle of the scanning signals being modulated in accordance with a modulation function over the position segment, and a control and evaluation unit configured to generate incremental first position information from the scanning signals of the two individual scanning units and second position information from the modulation of the duty cycle of the scanning signals, characterized in that the encoder apparatus comprises a second incremental scanning device having at least two individual scanning units in mutual phase offset for generating a respective scanning signal by scanning the measuring standard, which is arranged with a phase offset with respect to the first incremental scanning device, and in that the control and evaluation unit is configured to generate the second position information from the modulation of the duty cycle of the scanning signals of the first incremental scanning device and the modulation of the duty cycle of the scanning signals of the second incremental scanning device.
A power supply device comprising: a first line, a second line, and a third line, each having a different electric potential from one another; a battery circuit (11, 12) in which a fuel cell stack and an electric storage device are connected in series; and a first DC-DC converter, wherein both ends of the battery circuit (11, 12) are connected to the first line and the third line, a connection point of the electric storage device and the fuel cell stack of the battery circuit is connected to the second line, a primary side of the first DC-DC converter is connected to the second line and the third line, a secondary side of the first DC-DC converter is connected to the first line and the third line, and electric power is outputted from the first line and the third line, characterized in that the first DC-DC converter is of a chopper type comprising a plurality of choke coils being a common mode coil and includes a three-phase bridge circuit in which a switching element is bridge-connected, and a three-phase choke coil as the plurality of choke coils; a core of the common mode coil is a rectangular core; any one-phase choke coil of the three-phase choke coil is dispersed and wrapped around one pair of opposite sides among two pairs of opposing sides included in the rectangular core; and a two-phase choke coil of the three-phase choke coil, excluding the one-phase choke coil, is respectively concentrated and wrapped around another pair of opposite sides among the two pairs of opposing sides included in the rectangular core. a first line, a second line, and a third line, each having a different electric potential from one another; a battery circuit (11, 12) in which a fuel cell stack and an electric storage device are connected in series; and a first DC-DC converter, wherein both ends of the battery circuit (11, 12) are connected to the first line and the third line, a connection point of the electric storage device and the fuel cell stack of the battery circuit is connected to the second line, a primary side of the first DC-DC converter is connected to the second line and the third line, a secondary side of the first DC-DC converter is connected to the first line and the third line, and electric power is outputted from the first line and the third line, characterized in that the first DC-DC converter is of a chopper type comprising a plurality of choke coils being a common mode coil and includes a three-phase bridge circuit in which a switching element is bridge-connected, and a three-phase choke coil as the plurality of choke coils; a core of the common mode coil is a rectangular core; any one-phase choke coil of the three-phase choke coil is dispersed and wrapped around one pair of opposite sides among two pairs of opposing sides included in the rectangular core; and a two-phase choke coil of the three-phase choke coil, excluding the one-phase choke coil, is respectively concentrated and wrapped around another pair of opposite sides among the two pairs of opposing sides included in the rectangular core.
A pneumatic tire which has an electronic component provided therein, wherein the electronic component is provided outwards of the carcass in the tire axial direction, and the rubber member having the largest thickness in the tire axial direction among the rubber members disposed outwards of the electronic component in the tire axial direction contains 20 parts by mass or more of silica with respect to 100 parts by mass of the rubber component, characterized in that the rubber member having the largest thickness in the tire axial direction is a clinch. wherein the electronic component is provided outwards of the carcass in the tire axial direction, and the rubber member having the largest thickness in the tire axial direction among the rubber members disposed outwards of the electronic component in the tire axial direction contains 20 parts by mass or more of silica with respect to 100 parts by mass of the rubber component, characterized in that the rubber member having the largest thickness in the tire axial direction is a clinch.
A method performed by a Radio Network Node, RNN, for improving capacity in a wireless communications system providing massive Multiple Input Multiple Output, MIMO, and operating in a Time Division Duplex, TDD, mode, wherein the RNN serves a first wireless device and a second wireless device in the wireless communications system, and wherein the method comprises: - assigning (201,303) an uplink pilot signal to the first wireless device and assigning the same uplink pilot signal to the second wireless device; - transmitting (202,304), to the first wireless device, an indication of how second data (Data2) intended for the second wireless device will be comprised in a signal to be transmitted from the RNN to the first wireless device; - estimating (204,306) a combined channel based on the uplink pilot signal received from the first wireless device via a first channel and from the second wireless device via a second channel, wherein the combined channel is estimated as a combination of the first and second channels; - determining (205,307) a beamforming vector for the estimated combined channel; and - transmitting (206,311), by means of the beamforming vector, the signal to the first wireless device, wherein the signal comprises first data (Data1) and the second data (Data2), wherein the first data (Data1) is decoded only by the first wireless device. - assigning (201,303) an uplink pilot signal to the first wireless device and assigning the same uplink pilot signal to the second wireless device; - transmitting (202,304), to the first wireless device, an indication of how second data (Data2) intended for the second wireless device will be comprised in a signal to be transmitted from the RNN to the first wireless device; - estimating (204,306) a combined channel based on the uplink pilot signal received from the first wireless device via a first channel and from the second wireless device via a second channel, wherein the combined channel is estimated as a combination of the first and second channels; - determining (205,307) a beamforming vector for the estimated combined channel; and - transmitting (206,311), by means of the beamforming vector, the signal to the first wireless device, wherein the signal comprises first data (Data1) and the second data (Data2), wherein the first data (Data1) is decoded only by the first wireless device.
A combustion duct for a gas turbine engine comprising: a combustion liner to receive products of combustion, and deliver them downstream toward a turbine rotor; an outer housing positioned radially outwardly of said combustion liner; a flow sleeve positioned radially intermediate said outer housing and said combustion liner, said flow sleeve defining a chamber, radially outwardly of said flow sleeve, for receiving cooling air, and a plurality of holes through said flow sleeve to deliver cooling air against an outer periphery of said combustion liner; and a plurality of tabs associated with at least some of said holes in said flow sleeve, said tabs being positioned to extend radially inwardly on a downstream side of said holes, characterised in that: said plurality of tabs are associated with a ring that extends for more than 270° about a central axis of said flow sleeve; said ring has a cylindrical base within said flow sleeve, and said tabs extend radially inwardly for a greater distance than said base; and said base has base holes to correspond with said holes in said flow sleeve. a combustion liner to receive products of combustion, and deliver them downstream toward a turbine rotor; an outer housing positioned radially outwardly of said combustion liner; a flow sleeve positioned radially intermediate said outer housing and said combustion liner, said flow sleeve defining a chamber, radially outwardly of said flow sleeve, for receiving cooling air, and a plurality of holes through said flow sleeve to deliver cooling air against an outer periphery of said combustion liner; and a plurality of tabs associated with at least some of said holes in said flow sleeve, said tabs being positioned to extend radially inwardly on a downstream side of said holes, characterised in that: said plurality of tabs are associated with a ring that extends for more than 270° about a central axis of said flow sleeve; said ring has a cylindrical base within said flow sleeve, and said tabs extend radially inwardly for a greater distance than said base; and said base has base holes to correspond with said holes in said flow sleeve. said plurality of tabs are associated with a ring that extends for more than 270° about a central axis of said flow sleeve; said ring has a cylindrical base within said flow sleeve, and said tabs extend radially inwardly for a greater distance than said base; and said base has base holes to correspond with said holes in said flow sleeve.
Modular holding structure for ground surfacing, such as a floor, a stone surfacing or a pavement, said structure comprising a plurality of unitary modules connected together in order to design a flat holding able to be placed vertically between the ground and the surfacing, in which structure each module is a plate having a polygonal periphery which is bounded by a horizontal superior planar face and by several vertical side faces, each side face being provided with consecutive, and complementary tenons and mortises designed in order to allow the connection of two adjacent unitary modules through fitting along the vertical direction, characterized in that at least some tenons protrude vertically above the surface of said superior horizontal face of the plate and several tenons 40 successively aligned along each face 16 defining between them consecutive mortises 42 complementary to tenons 40.
An engine cooling system comprising: a Rankine cycle configured such that a first coolant circulates through a cooling pump, an evaporator, an expander, and a condenser, in this order; a cooling cycle for an air conditioner configured to cool a vehicle by utilizing a vaporization of a liquid second coolant; a radiator which is disposed at a front surface of the vehicle, and through which engine-main-body cooling water flows; and a sub-radiator through which intercooler cooling water flows, the engine cooling system using some of inlet-side cooling water of the radiator as a heating source for the evaporator, and some of outlet-side cooling water of the sub-radiator as a cooling source for the condenser, characterized in that the vaporized second coolant is cooled and again liquefied by using some of the outlet-side cooling water of the sub-radiator in the condenser. a Rankine cycle configured such that a first coolant circulates through a cooling pump, an evaporator, an expander, and a condenser, in this order; a cooling cycle for an air conditioner configured to cool a vehicle by utilizing a vaporization of a liquid second coolant; a radiator which is disposed at a front surface of the vehicle, and through which engine-main-body cooling water flows; and a sub-radiator through which intercooler cooling water flows, the engine cooling system using some of inlet-side cooling water of the radiator as a heating source for the evaporator, and some of outlet-side cooling water of the sub-radiator as a cooling source for the condenser, characterized in that the vaporized second coolant is cooled and again liquefied by using some of the outlet-side cooling water of the sub-radiator in the condenser.
A method of decoding video data, the method comprising: receiving a first block of video data encoded using an inter-prediction mode; associating a first intra-prediction mode with the first block of video data, wherein the first intra-prediction mode is associated with second block of video data; and determining a second intra-prediction mode for a neighbor block of video data based at least in part on the first intra-prediction mode, wherein the second block of video data is one of a collocated block in a different frame, a reference block in a reference frame located using a motion vector, or a spatially neighboring block within the same frame. receiving a first block of video data encoded using an inter-prediction mode; associating a first intra-prediction mode with the first block of video data, wherein the first intra-prediction mode is associated with second block of video data; and determining a second intra-prediction mode for a neighbor block of video data based at least in part on the first intra-prediction mode, wherein the second block of video data is one of a collocated block in a different frame, a reference block in a reference frame located using a motion vector, or a spatially neighboring block within the same frame.