A system comprising an extracorporeal blood treatment machine, and a tube set that can be mounted detachably and, resp., interchangeably and in a predefined arrangement on the blood treatment machine, wherein the extracorporeal blood treatment machine, comprises a blood treatment device a conveying device for conveying blood through the blood treatment device, and a connection mask on which pressure sensor connections (26, 28, 30) are located; wherein the tube set comprises at least one blood supply line for supplying blood to the blood treatment device, one blood return line for returning treated blood from the blood treatment device, one pump section adapted and provided to be inserted into the conveying device of the extracorporeal blood treatment machine, as well as at least two pressure-monitoring lines (14, 16, 18) each of which branches off the blood supply line or the blood return line at a branch (20, 22, 24); wherein the pressure-monitoring lines (14, 16, 18) can be connected to the pressure sensor connections (26, 28, 30) to transmit pressure from the branches (20, 22, 24) to the corresponding pressure sensor connection (26, 28, 30), characterized in that the pressure sensor connections (26, 28, 30) are spaced apart from one another and positioned on the extracorporeal blood treatment machine so as to match the tube set, and the length of the pressure-monitoring lines (14, 16, 18) as well as the positioning of the branches (20, 22, 24) are adapted such that, when the tube set is mounted in the predefined arrangement on the connection mask, each pressure-monitoring line (14, 16, 18), owing to its limited length and the predefined arrangement of the associated branch (20, 22, 24) on the blood treatment machine, can be connected exclusively to a respective one of the pressure sensor connections (26, 28, 30). the extracorporeal blood treatment machine, comprises a blood treatment device a conveying device for conveying blood through the blood treatment device, and a connection mask on which pressure sensor connections (26, 28, 30) are located; wherein the tube set comprises at least one blood supply line for supplying blood to the blood treatment device, one blood return line for returning treated blood from the blood treatment device, one pump section adapted and provided to be inserted into the conveying device of the extracorporeal blood treatment machine, as well as at least two pressure-monitoring lines (14, 16, 18) each of which branches off the blood supply line or the blood return line at a branch (20, 22, 24); wherein the pressure-monitoring lines (14, 16, 18) can be connected to the pressure sensor connections (26, 28, 30) to transmit pressure from the branches (20, 22, 24) to the corresponding pressure sensor connection (26, 28, 30), characterized in that the pressure sensor connections (26, 28, 30) are spaced apart from one another and positioned on the extracorporeal blood treatment machine so as to match the tube set, and the length of the pressure-monitoring lines (14, 16, 18) as well as the positioning of the branches (20, 22, 24) are adapted such that, when the tube set is mounted in the predefined arrangement on the connection mask, each pressure-monitoring line (14, 16, 18), owing to its limited length and the predefined arrangement of the associated branch (20, 22, 24) on the blood treatment machine, can be connected exclusively to a respective one of the pressure sensor connections (26, 28, 30).