A liquid-liquid extraction system adapted for the flow of two or more liquids therein comprising: (i) a mixer settler sub-system comprising: one or more mixer settlers connected in series, a first inlet for a first liquid feed stream, a second inlet for a second liquid feed stream, a first outlet for a first product stream, a second outlet for a first byproduct stream, (ii) a counter-current liquid-liquid extraction column and comprising within one common vessel: a first inlet for a third liquid feed stream, a second inlet for a fourth liquid feed stream, a first outlet for a second product stream, a second outlet for a second byproduct stream, a mixing section comprising an agitation means and a static section comprising an internal, wherein the first outlet of the mixer settler sub-system is in fluid communication with the first inlet of the column, wherein the second inlet of the mixer settler sub-system is in fluid communication with the second inlet of the counter-current liquid-liquid extraction column, and wherein either i) the first inlet of the column, the static section of the column and the second outlet of the column are all substantially located within a bottom portion of the column, and wherein the second inlet of the column, the mixing section of the column, and the first outlet of the column are all substantially located within a top portion of the column, wherein the first inlet of the sub-system and the second outlet of the sub-system are both substantially located within a bottom portion of the sub-system, and wherein the second inlet of the sub-system and the first outlet of the sub-system are both substantially located within a top portion of the sub-system, or ii) the first inlet of the column, the static section of the column and the second outlet of the column are all substantially located within a top portion of the column, and wherein the second inlet of the column, the mixing section of the column, and the first outlet of the column are all substantially located within a bottom portion of the column, wherein the first inlet of the sub-system and the second outlet of the sub-system are both substantially located within a top portion of the sub-system, and wherein the second inlet of the sub-system and the first outlet of the sub-system are both substantially located within a bottom portion of the sub-system. (i) a mixer settler sub-system comprising: one or more mixer settlers connected in series, a first inlet for a first liquid feed stream, a second inlet for a second liquid feed stream, a first outlet for a first product stream, a second outlet for a first byproduct stream, one or more mixer settlers connected in series, a first inlet for a first liquid feed stream, a second inlet for a second liquid feed stream, a first outlet for a first product stream, a second outlet for a first byproduct stream, (ii) a counter-current liquid-liquid extraction column and comprising within one common vessel: a first inlet for a third liquid feed stream, a second inlet for a fourth liquid feed stream, a first outlet for a second product stream, a second outlet for a second byproduct stream, a mixing section comprising an agitation means and a static section comprising an internal, wherein the first outlet of the mixer settler sub-system is in fluid communication with the first inlet of the column, wherein the second inlet of the mixer settler sub-system is in fluid communication with the second inlet of the counter-current liquid-liquid extraction column, and wherein either a first inlet for a third liquid feed stream, a second inlet for a fourth liquid feed stream, a first outlet for a second product stream, a second outlet for a second byproduct stream, a mixing section comprising an agitation means and a static section comprising an internal, wherein the first outlet of the mixer settler sub-system is in fluid communication with the first inlet of the column, wherein the second inlet of the mixer settler sub-system is in fluid communication with the second inlet of the counter-current liquid-liquid extraction column, and wherein either i) the first inlet of the column, the static section of the column and the second outlet of the column are all substantially located within a bottom portion of the column, and wherein the second inlet of the column, the mixing section of the column, and the first outlet of the column are all substantially located within a top portion of the column, wherein the first inlet of the sub-system and the second outlet of the sub-system are both substantially located within a bottom portion of the sub-system, and wherein the second inlet of the sub-system and the first outlet of the sub-system are both substantially located within a top portion of the sub-system, or ii) the first inlet of the column, the static section of the column and the second outlet of the column are all substantially located within a top portion of the column, and wherein the second inlet of the column, the mixing section of the column, and the first outlet of the column are all substantially located within a bottom portion of the column, wherein the first inlet of the sub-system and the second outlet of the sub-system are both substantially located within a top portion of the sub-system, and wherein the second inlet of the sub-system and the first outlet of the sub-system are both substantially located within a bottom portion of the sub-system.