A method for preparing a restored composition suitable for use in improving viability of aged cells, the method comprising: providing a donor composition wherein the donor composition was previously obtained by: (i) administering a mobilizer to a donor subject; and (ii) collecting the donor composition from the peripheral blood of the donor subject, and wherein the donor composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; providing a receiver composition wherein the receiver composition was previously obtained by: (i) administering a mobilizer to a receiver subject; and (ii) collecting the receiver composition from the peripheral blood of the receiver subject, wherein the receiver composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition with a cell-free portion of the donor composition to produce a restored composition wherein the restored composition comprises cells that have an altered expression of at least one gene selected from the group consisting of GPX-1 (encoding for glutathione peroxidase-I), SODl (encoding for superoxide dismutase-1); REL-A (encoding for p65 of the NFκB heterodimer); LIG-4 (encoding for DNA Ligase-4); GLB-1 (encoding for β-galactosidase) and, pl6INK4a; wherein the donor and receiver received the mobilizer prior to collection of the donor composition and the receiver composition, respectively; and wherein the donor subject and receiver subject differ in age by greater than 10 years and the receiver subject's age is greater than the donor subject's age. providing a donor composition wherein the donor composition was previously obtained by: (i) administering a mobilizer to a donor subject; and (ii) collecting the donor composition from the peripheral blood of the donor subject, and wherein the donor composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; (i) administering a mobilizer to a donor subject; and (ii) collecting the donor composition from the peripheral blood of the donor subject, and wherein the donor composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; providing a receiver composition wherein the receiver composition was previously obtained by: (i) administering a mobilizer to a receiver subject; and (ii) collecting the receiver composition from the peripheral blood of the receiver subject, wherein the receiver composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; and (i) administering a mobilizer to a receiver subject; and (ii) collecting the receiver composition from the peripheral blood of the receiver subject, wherein the receiver composition comprises a plurality of adult stem cell types wherein the adult stem cell types comprise mesenchymal stem cells, hematopoietic stem cells, early hematopoietic progenitor cells, late hematopoietic progenitor cells, endothelial progenitor cells or combinations thereof; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition with a cell-free portion of the donor composition to produce a restored composition wherein the restored composition comprises cells that have an altered expression of at least one gene selected from the group consisting of GPX-1 (encoding for glutathione peroxidase-I), SODl (encoding for superoxide dismutase-1); REL-A (encoding for p65 of the NFκB heterodimer); LIG-4 (encoding for DNA Ligase-4); GLB-1 (encoding for β-galactosidase) and, pl6INK4a; wherein the donor and receiver received the mobilizer prior to collection of the donor composition and the receiver composition, respectively; and wherein the donor subject and receiver subject differ in age by greater than 10 years and the receiver subject's age is greater than the donor subject's age.