An apparatus comprising: (a) a handle assembly, wherein the handle assembly comprises: (i) a body comprising a cable, and (ii) a cartridge comprising an actuator, a housing, and a wire coupled with the actuator, wherein the cartridge is configured to removably couple with the body, wherein the actuator is integrated into the cartridge such that the actuator is removable from the body; and (b) a guide tube extending distally from the handle assembly, wherein the guide tube has a distal end, wherein a proximal portion of the wire is configured to be fixedly secured within an opening formed in a proximal surface of the housing such that the proximal portion of the wire is configured to remain stationary relative to the housing, wherein the proximal portion of the wire comprises an adapter configured to couple the wire of the cartridge with the cable, wherein the wire is configured to be slidably disposed in the guide tube, wherein the wire has a distal end including a sensor (135, 136), wherein the sensor is configured to cooperate with a navigation system, to generate a map of anatomical structures within a patient and/or to provide image guided navigation of anatomical structures within a patient, wherein the actuator is movable relative to the body to move the wire relative to the guide tube when the cartridge is coupled with the body, wherein the wire forms a service loop within the handle assembly, wherein the service loop is configured to permit a distal portion of the wire to translate relative to the handle assembly while the proximal portion of the wire remains fixedly secured relative to the handle assembly, wherein the actuator is coupled with the distal portion of the wire, distally of service loop. (a) a handle assembly, wherein the handle assembly comprises: (i) a body comprising a cable, and (ii) a cartridge comprising an actuator, a housing, and a wire coupled with the actuator, wherein the cartridge is configured to removably couple with the body, wherein the actuator is integrated into the cartridge such that the actuator is removable from the body; and (i) a body comprising a cable, and (ii) a cartridge comprising an actuator, a housing, and a wire coupled with the actuator, wherein the cartridge is configured to removably couple with the body, wherein the actuator is integrated into the cartridge such that the actuator is removable from the body; and (b) a guide tube extending distally from the handle assembly, wherein the guide tube has a distal end, wherein a proximal portion of the wire is configured to be fixedly secured within an opening formed in a proximal surface of the housing such that the proximal portion of the wire is configured to remain stationary relative to the housing, wherein the proximal portion of the wire comprises an adapter configured to couple the wire of the cartridge with the cable, wherein the wire is configured to be slidably disposed in the guide tube, wherein the wire has a distal end including a sensor (135, 136), wherein the sensor is configured to cooperate with a navigation system, to generate a map of anatomical structures within a patient and/or to provide image guided navigation of anatomical structures within a patient, wherein the actuator is movable relative to the body to move the wire relative to the guide tube when the cartridge is coupled with the body, wherein the wire forms a service loop within the handle assembly, wherein the service loop is configured to permit a distal portion of the wire to translate relative to the handle assembly while the proximal portion of the wire remains fixedly secured relative to the handle assembly, wherein the actuator is coupled with the distal portion of the wire, distally of service loop.