A permanent mold casting machine that pours via a stoke molten metal held in a holding furnace into a set of molds consisting of a upper and lower molds (11, 5) so as to manufacture a casting product, the mold casting machine comprising a base table; a holding furnace; four supporting frames disposed on the surface of the base table, near their respective four corners; a lower mold base placed across the upper ends of the four supporting frames; a lower mold attached to the lower mold base and placed at the fixed position of the lower mold base; upper mold lifting and lowering cylinders, attached to the two respective supporting frames of the four supporting frames, which two frames are positioned on a diagonal line of the lower mold base; a lifting and lowering frame installed across the upper ends of the rods of the upper mold lifting and lowering cylinders; two guide rods, attached to the two respective supporting frames of the four supporting frames, which two supporting frames are located on the other diagonal line that crosses the above diagonal line, two guide rods movable vertically in sliding movement along the supporting frames and fastened vertically to the lower surface of the lifting and lowering frame and having a fastening portion that fixes the lifting and lowering frame to the predetermined position; a mold clamping mechanism attached to the lifting and lowering frame, the mold clamping mechanism comprising an upper mold lifting and lowering means, to the lower surface of which the upper mold can be attached, and which performs mold assembling of the upper and lower molds (11, 5) and the separation of the molds (11, 5) by lifting and lowering the upper mold relative to the lifting and lowering frame and to the lower mold that is fixed; and a casting product pushing-out mechanism positioned below the lower part of the lifting and lowering frame, which pushing-out mechanism pushes out, and separates from the upper mold, the cast product that adheres to the upper mold when the upper mold and the lower mold are separated after the pouring is completed, wherein the lifting and lowering frame, to which the mold clamping mechanism is attached, can be fastened by the fastening portion of the guide rod to a fastening mechansim, wherein in a position close to the lower mold, in which position the guide rods are at their lowest ends, the end parts of the two guide rods are adapted to be engaged with the fastening mechanism to fix the lifting and lowering frame attached to the mold clamping mechanism in the predetermined position so that the lifting and lowering frame is unmoveable relatively to the guide rods and the lower mold, wherein the upper mold lifting and lowering means of the mold clamping mechanism is adapted to lower the upper mold into contact with the lower mold to form a mold assembly, while the lifting and lowering frame remains in the fixed predetermined position, and wherein the upper mold lifting and lowering means of the mold clamping mechanism is adapted to separate the upper mold from the lower mold, while the lifting and lowering frame remains in the fixed predetermined position and is unmovable relatively to the guide rods and the lower mold, and wherein the lifting and lowering frame with the two lifting and lowering cylinders is adapted to lift the upper mold to a position allowing separation of the casting product from the upper mold.