A method for optimizing a liquid class for a laboratory automation device, wherein the liquid class comprises control parameters for controlling the laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, the method comprising: initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class; optimizing the liquid class iteratively with the genetic algorithm by: applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class, indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes. initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class; optimizing the liquid class iteratively with the genetic algorithm by: applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class, indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes. applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class, indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes.