A device for chromatography comprising: - a modulator having (i) an inlet port (11, 37) for receiving effluent from a first chromatography column, and (ii) two independent ports (12, 16, resp. 36, 39) for receiving a flow from one or more electronic pressure and/or flow control devices located externally with respect to said modulator, and (iii) two further ports (17, 18; resp. 40, 41); - either one or two accumulation capillary sample loops located externally with respect to said modulator, or either one or two accumulation capillary sample loops integrated in said modulator; the modulator further comprising a system of integrated channels, whereby said accumulation capillary sample loop(s) is/are connected between said first (12, 36) and second (16, 39) independent ports and to said inlet port (11, 37); - an injector directly linked to the modulator; wherein the device further comprises: - a needle valve, to the modulator, for regulating the flow exiting said accumulation capillary sample loop(s), and - first and second channels (16-17, 16-18 resp. 38-40, 38-41), connected to said accumulation capillary sample loop(s), said channels integrated in said modulator, the first channel is located between the first independent port and the first further port (17, 40), further connectable to a second chromatography column, the second channel is located between the first independent port and the second further port (18, 41), further connected to a capillary column, to split, in a controlled manner, using the needle valve, the flow exiting the accumulation capillary loop(s) and to release the pressure in excess in the first channel and, consequently, in the second chromatography column, when emptying said accumulation capillary loop(s), - a capillary column, connected between the second further port (18, 41) and the needle valve, - two chromatography columns (4, 22), - one or more gas chromatography ovens (1, 6), - an automatic flow controller or an automatic pressure controller, - a two position (open/closed) solenoid valve, wherein said needle valve external to the modulator is connected in series to a two position (open/closed) solenoid valve. - a modulator having (i) an inlet port (11, 37) for receiving effluent from a first chromatography column, and (ii) two independent ports (12, 16, resp. 36, 39) for receiving a flow from one or more electronic pressure and/or flow control devices located externally with respect to said modulator, and (iii) two further ports (17, 18; resp. 40, 41); - either one or two accumulation capillary sample loops located externally with respect to said modulator, or either one or two accumulation capillary sample loops integrated in said modulator; the modulator further comprising a system of integrated channels, whereby said accumulation capillary sample loop(s) is/are connected between said first (12, 36) and second (16, 39) independent ports and to said inlet port (11, 37); - an injector directly linked to the modulator; wherein the device further comprises: - a needle valve, to the modulator, for regulating the flow exiting said accumulation capillary sample loop(s), and - first and second channels (16-17, 16-18 resp. 38-40, 38-41), connected to said accumulation capillary sample loop(s), said channels integrated in said modulator, the first channel is located between the first independent port and the first further port (17, 40), further connectable to a second chromatography column, the second channel is located between the first independent port and the second further port (18, 41), further connected to a capillary column, to split, in a controlled manner, using the needle valve, the flow exiting the accumulation capillary loop(s) and to release the pressure in excess in the first channel and, consequently, in the second chromatography column, when emptying said accumulation capillary loop(s), - a capillary column, connected between the second further port (18, 41) and the needle valve, - two chromatography columns (4, 22), - one or more gas chromatography ovens (1, 6), - an automatic flow controller or an automatic pressure controller, - a two position (open/closed) solenoid valve, - a needle valve, to the modulator, for regulating the flow exiting said accumulation capillary sample loop(s), and - first and second channels (16-17, 16-18 resp. 38-40, 38-41), connected to said accumulation capillary sample loop(s), said channels integrated in said modulator, the first channel is located between the first independent port and the first further port (17, 40), further connectable to a second chromatography column, the second channel is located between the first independent port and the second further port (18, 41), further connected to a capillary column, to split, in a controlled manner, using the needle valve, the flow exiting the accumulation capillary loop(s) and to release the pressure in excess in the first channel and, consequently, in the second chromatography column, when emptying said accumulation capillary loop(s), - a capillary column, connected between the second further port (18, 41) and the needle valve, - two chromatography columns (4, 22), - one or more gas chromatography ovens (1, 6), - an automatic flow controller or an automatic pressure controller, - a two position (open/closed) solenoid valve,