mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical formulation comprising an exendin-4 or analog thereof for use in a method for lowering total cholesterol levels, LDL-cholesterol levels, or triglyceride levels in a patient in need thereof, the method comprising: identifying a patient in need of a reduction in total cholesterol levels, LDL-cholesterol levels, or triglyceride levels; and administering to the patient the pharmaceutical formulation once per week in an amount sufficient to maintain a steady state geometric mean plasma concentration of the exendin-4 or analog thereof of 145 pg/mL to 700 pg/mL to reduce total cholesterol levels, LDL-cholesterol levels, or triglyceride levels in the patient, wherein said analog has 10 or less amino acid substitutions, additions or deletions as compared to exendin-4, and wherein the pharmaceutical formulation is administered by subcutaneous injection. identifying a patient in need of a reduction in total cholesterol levels, LDL-cholesterol levels, or triglyceride levels; and administering to the patient the pharmaceutical formulation once per week in an amount sufficient to maintain a steady state geometric mean plasma concentration of the exendin-4 or analog thereof of 145 pg/mL to 700 pg/mL to reduce total cholesterol levels, LDL-cholesterol levels, or triglyceride levels in the patient, wherein said analog has 10 or less amino acid substitutions, additions or deletions as compared to exendin-4, and wherein the pharmaceutical formulation is administered by subcutaneous injection.
Use of a mixture which is liquid at room temperature and contains two or more compounds selected from isomers of benzyltoluene and/or dibenzyltoluene in catalytic methods for binding hydrogen to and/or releasing hydrogen from the mixture.
Hot air device particularly for heating glasses frames for the purpose of shaping said frames, consisting of - a blowing device with a fan impeller that can be driven by an electric motor; - an electric heating device; and - an air output device, said electric motor being a variable-speed motor, characterised in that an unobstructed distance is selected between the blowing device and the heating device such that a uniform air flow generated by the fan impeller is adjusted at at least one inlet of the heating device, and in that the heating device is held in an air duct, which extends conically from an area with the smallest diameter both in the direction of the air output device and in the direction of the blowing device. - a blowing device with a fan impeller that can be driven by an electric motor; - an electric heating device; and - an air output device,
A method for manufacturing paper or thermoplastic foil printable with an inkjet printer for use as a decor paper, respectively decor foil, in a laminate panel, wherein the method at least comprises the following steps: - the step of providing a paper layer or a thermoplastic foil; - the step of coating at least one side of said paper layer, respectively of said foil, with an inkjet receiver coating comprising at least a pigment; wherein said pigment comprises aluminum silicates, characterized in that the pigment represents between 30 and 85% on dry weight of the inkjet receiver coating, in that the amount of silica is limited to less than the 10 wt%, more preferably less than 1 wt%, based on the whole content of pigments, in that the said inkjet receiver coating comprises a binder wherein the binder represents less than 10%, preferably less than 1% based on dry weight of the composition and in that the inkjet receiver coating comprises a flocculant wherein said flocculant content is between 20% and 60% based on dry weight of the inkjet receiver coating. - the step of providing a paper layer or a thermoplastic foil; - the step of coating at least one side of said paper layer, respectively of said foil, with an inkjet receiver coating comprising at least a pigment;
Method for operating a combustion engine comprising an internal combustion engine which forms at least two combustion chambers in which thermodynamic cyclic processes can be carried out during operation of the internal combustion engine, wherein gas exchanges in the combustion chambers are then controlled by means of gas exchange valves (28, 30), which are actuated by means of cams (60, 62) of one or more camshafts, and wherein - a full-operation state is provided, in which the thermodynamic cyclic processes are carried out both in a first combustion chamber and in a second combustion chamber, and - a partial-operation state is provided, in which the thermodynamic cyclic processes are carried out in the first combustion chamber and the thermodynamic cyclic processes are not carried out in the second combustion chamber, and wherein, for switching between the full-operation state and the partial-operation state, a change between use of a full-operation cam, the cam contour of which brings about a full-operation valve lift curve, and the use of a partial-operation cam, the cam contour of which brings about a partial-operation valve lift curve, is made for actuating at least one gas exchange valve (28, 30) assigned to the first combustion chamber, characterized in that the partial-operation valve lift curve has a greater slope than the full-operation valve lift curve in at least one section in the half comprising the transition between the opening movement and the closing movement of the gas exchange valve (28, 30). - a full-operation state is provided, in which the thermodynamic cyclic processes are carried out both in a first combustion chamber and in a second combustion chamber, and - a partial-operation state is provided, in which the thermodynamic cyclic processes are carried out in the first combustion chamber and the thermodynamic cyclic processes are not carried out in the second combustion chamber,
- Use as a defense elicitor/stimulator in terrestrial plants of an extract or an extract fraction of at least one agarophyte red alga, said extract or said extract fraction containing at least one oligosaccharide having 2 to 50 ose units covalently bound to one another, wherein polysaccharides having more than 50 ose units covalently bound to one another can be contained without exceeding 0.01% by weight relative to the total oligosaccharides/polysaccharides.
Packaging and application device comprising: - a composition to be applied to the nails, skin or lips; - an applicator comprising: - an application element; - a rod comprising a portion comprising at least two branches forming between them a cavity, said cavity making it possible to retain a reserve of composition by capillary action and opening onto the outer surface of the rod and with non-constant cross-section along the rod, in which said portion is located between a proximal portion and a distal portion of the rod, said distal portion carrying the application element, and in which said cavity is delimited at the bottom by at least one inclined surface extending towards the outside and downwards. - a composition to be applied to the nails, skin or lips; - an applicator comprising: - an application element; - a rod comprising a portion comprising at least two branches forming between them a cavity, said cavity making it possible to retain a reserve of composition by capillary action and opening onto the outer surface of the rod and with non-constant cross-section along the rod, in which said portion is located between a proximal portion and a distal portion of the rod, said distal portion carrying the application element, and in which said cavity is delimited at the bottom by at least one inclined surface extending towards the outside and downwards. - an application element; - a rod comprising a portion comprising at least two branches forming between them a cavity, said cavity making it possible to retain a reserve of composition by capillary action and opening onto the outer surface of the rod and with non-constant cross-section along the rod, in which said portion is located between a proximal portion and a distal portion of the rod, said distal portion carrying the application element, and in which said cavity is delimited at the bottom by at least one inclined surface extending towards the outside and downwards.
Method for associating lighting effects with discrete frequency signals extracted from an audio signal, at music events wherein there is lighting with lighting elements that are associated with lighting effects according to the audio signal, the method comprising the following stages: - a first stage wherein the audio signal is captured, - a second stage wherein the audio signal is processed, - a third stage wherein a graphical interface is implemented in order to display on a display graphic icons representing the lighting elements, and to enable a user to interact by associating a lighting element to a lighting effect, wherein the method is characterised in that: - the second stage comprising processes the audio signal, captured in the first stage, in order to decompose it and extract discrete frequency signals, - the third stage comprises displaying a temporal evolution of the discrete frequency signals, processed in the second stage, are displayed in order to graphically enable the user to associate, or disassociate, the graphic icons with the corresponding lighting element and with a discrete frequency signal by placing on the display a graphic icon underneath the corresponding discrete frequency signal, and in that the method further comprises - a fourth stage wherein a value of the amplitude of the discrete frequency signals is sent to at least one lighting element with which it has been associated so that its degree of illumination is equivalent to its amplitude. - a first stage wherein the audio signal is captured, - a second stage wherein the audio signal is processed, - a third stage wherein a graphical interface is implemented in order to display on a display graphic icons representing the lighting elements, and to enable a user to interact by associating a lighting element to a lighting effect, wherein the method is characterised in that: - the second stage comprising processes the audio signal, captured in the first stage, in order to decompose it and extract discrete frequency signals, - the third stage comprises displaying a temporal evolution of the discrete frequency signals, processed in the second stage, are displayed in order to graphically enable the user to associate, or disassociate, the graphic icons with the corresponding lighting element and with a discrete frequency signal by placing on the display a graphic icon underneath the corresponding discrete frequency signal, and in that the method further comprises - a fourth stage wherein a value of the amplitude of the discrete frequency signals is sent to at least one lighting element with which it has been associated so that its degree of illumination is equivalent to its amplitude.
An insertion device for inserting a medical device into a living body, comprising: a needle portion (11, 111) internally defining an accommodation space for accommodating the medical device and configured to be inserted into a living body together with the medical device to be accommodated in the accommodation space; and a movable portion relatively movable with respect to the needle portion (11, 111) in the accommodation space in a direction of insertion of the needle portion (11, 111), wherein the needle portion (11, 111) comprises a clamping portion configured to change a form in the accommodation space between a first form in which the clamping portion clamps the medical device accommodated in the accommodation space and a second form in which the clamping portion does not clamp the medical device accommodated in the accommodation space, and the movable portion is configured to engage the clamping portion by moving in the direction of insertion with respect to the needle portion (11, 111) to change the form of the clamping portion from the first form to the second form. a needle portion (11, 111) internally defining an accommodation space for accommodating the medical device and configured to be inserted into a living body together with the medical device to be accommodated in the accommodation space; and a movable portion relatively movable with respect to the needle portion (11, 111) in the accommodation space in a direction of insertion of the needle portion (11, 111), wherein the needle portion (11, 111) comprises a clamping portion configured to change a form in the accommodation space between a first form in which the clamping portion clamps the medical device accommodated in the accommodation space and a second form in which the clamping portion does not clamp the medical device accommodated in the accommodation space, and the movable portion is configured to engage the clamping portion by moving in the direction of insertion with respect to the needle portion (11, 111) to change the form of the clamping portion from the first form to the second form.
A method of inducing differentiation of pluripotent stem cells into endoderm cells, mesoderm cells or ectoderm cells, comprising the following steps: (a) culturing mammal-derived pluripotent stem cells which are ES cells or iPS cells in a differentiation culture medium; and then (b) in an amino acid deprived differentiation culture medium which does not contain one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine, wherein said ES cells or iPS cells are cultured in said amino acid deprived differentiation culture medium which does not contain one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine for at least 5 hours and at most 4 days or less. (a) culturing mammal-derived pluripotent stem cells which are ES cells or iPS cells in a differentiation culture medium; and then (b) in an amino acid deprived differentiation culture medium which does not contain one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine, wherein said ES cells or iPS cells are cultured in said amino acid deprived differentiation culture medium which does not contain one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine for at least 5 hours and at most 4 days or less.
An apparatus with a magnetorheological brake device for braking relative motions, comprising at least two brake components (2, 3), wherein between the brake components (2, 3), a receiving space with a braking gap is formed, containing a magnetorheological medium with magnetically polarizable particles that can be influenced by a magnetic field, wherein at least one core and at least one electric coil unit is comprised to generate a controllable magnetic field in the braking gap, wherein at least part of the magnetically polarizable particles is configured to form and to interlock an interlocking structure under the influence of the magnetic field, characterized in that at least 25% of the magnetically polarizable particles, which are non-round particles, have a ratio of maximum diameter to maximum transverse extent perpendicular thereto of greater than 1.25.
An apparatus for performing positioning operations, comprising: a transceiver of a user equipment, UE, configured to: receive a downlink physical channel from a base station, the downlink physical channel received on one or more slots of one or more subframes of one or more radio frames, the downlink physical channel carrying user data and/or control information from the base station to the UE, the downlink physical channel comprising a physical downlink control channel, PDCCH, or a physical downlink shared channel, PDSCH; receive, from the base station, an indication in a downlink control information, DCI, scheduling message that the base station will transmit reference signals for positioning on the downlink physical channel; and in response to receiving the indication, perform a positioning measurement of a reference signal received from the base station on the downlink physical channel. receive a downlink physical channel from a base station, the downlink physical channel received on one or more slots of one or more subframes of one or more radio frames, the downlink physical channel carrying user data and/or control information from the base station to the UE, the downlink physical channel comprising a physical downlink control channel, PDCCH, or a physical downlink shared channel, PDSCH; receive, from the base station, an indication in a downlink control information, DCI, scheduling message that the base station will transmit reference signals for positioning on the downlink physical channel; and in response to receiving the indication, perform a positioning measurement of a reference signal received from the base station on the downlink physical channel.
A method to compensate for blooming of a shape of a spherical object in an image of that object generated by a digital video camera, blooming causing the true size of the object to appear in the image as an elliptical shape smaller or larger than it actually is, in dependence upon a brightness difference between the shape and the image background, the method comprising; sampling a plurality of pixels outside of the shape; determining a brightness of each of the sampled pixels; averaging the brightness of the sampled pixels outside of the shape; determining the semi-major axis of the ellipse; and compensating for blooming of the shape in the captured image by expanding or contracting the size of the shape in the captured image based on the difference between a brightness of the shape in the captured image and the average brightness of the sampled pixels, wherein compensating for blooming includes applying an empirical data mapping to adjust the semi-major axis based on the difference between the brightness of the shape and the average brightness of the sampled pixels.
A rodent whose genome comprises a replacement of a fragment of an endogenous rodent Dpp4 gene at an endogenous rodent Dpp4 locus with a fragment of a human DPP4 gene to form a modified DPP4 gene, wherein: said fragment of a human DPP4 gene comprises at least one exon of the human DPP4 gene; the modified DPP4 gene encodes a human DPP4 protein; expression of the modified DPP4 gene is under control of rodent regulatory elements at the endogenous rodent Dpp4 locus; the rodent is a mouse or a rat; and the rodent exhibits lung inflammation when infected with Middle East respiratory syndrome coronavirus (MERS-CoV). said fragment of a human DPP4 gene comprises at least one exon of the human DPP4 gene; the modified DPP4 gene encodes a human DPP4 protein; expression of the modified DPP4 gene is under control of rodent regulatory elements at the endogenous rodent Dpp4 locus; the rodent is a mouse or a rat; and the rodent exhibits lung inflammation when infected with Middle East respiratory syndrome coronavirus (MERS-CoV).
An oil gel capsule comprising: an oil gel comprising an oil and a gelator; and a surfactant bonded to the oil gel, wherein the oil is an engine oil, the gelator is 12-hydroxyoctadecanoic acid, and a content of the 12-hydroxyoctadecanoic acid is 1 to 10 wt% based on a total weight of the engine oil, wherein the oil gel has a phase transition temperature at which the oil gel in a gel state is liquefied in a liquid state or the oil gel in a liquid state gels into the oil gel in a gel state of 60°C or more and 70°C or less, and wherein the oil gel capsules have a size of 0.1 μm or more and 1 μm or less. an oil gel comprising an oil and a gelator; and a surfactant bonded to the oil gel, wherein the oil is an engine oil, the gelator is 12-hydroxyoctadecanoic acid, and a content of the 12-hydroxyoctadecanoic acid is 1 to 10 wt% based on a total weight of the engine oil, wherein the oil gel has a phase transition temperature at which the oil gel in a gel state is liquefied in a liquid state or the oil gel in a liquid state gels into the oil gel in a gel state of 60°C or more and 70°C or less, and wherein the oil gel capsules have a size of 0.1 μm or more and 1 μm or less.
Hydroxypropylcellulose microparticles, having a volume-average particle size of at least 0.1 μm but less than 15 μm, preferably of at least 0.1 μm but less than 10 μm, characterized in that the hydroxypropyl group content is within a range from 53 to 78% by weight.
A flexible tubular pipe intended for transporting hydrocarbons produced by a superposition of successive independent layers comprising at least, from the inside outward, an internal sealing sheath, a short-pitch helical winding of a metallic element, at least one tensile armor ply (6, 7) wound with a long pitch characterized in that the flexible tubular pipe comprises a protective external sealing sheath consisting of an extruded layer made of polymer material comprising two, respectively inner and outer, faces opposite one another (81, 82), the sheath comprising at least one reinforcing band consisting of a nonwoven material based on fibers that are at least partially embedded inside said polymer of said protective external sealing sheath, in order to mechanically bond together said reinforcing band and said protective external sealing sheath.
The use of orally administered probiotic Bifidobacteria having the accession number NCIMB 41003 for the cosmetic regulation of the signs of aging resulting from large pores; and/or for the cosmetic reduction of flaking of skin and/or scalp.
An exercise system, comprising: a movable element that is movable in the performance of an exercise, the movable element having at least one selectively adjustable operating parameter; and a controller that is configured to adjust the at least one selectively adjustable operating parameter of the movable element in order to increase or decrease the intensity of the exercise and thereby increase or decrease an exerciser's heart rate into one of a plurality of target heart rate zones, characterized in that each of the plurality of target heart rate zones is calculated using both an average work heart rate and a recovery heart rate of the exerciser, wherein the exerciser's average work heart rate comprises the exerciser's average heart rate during a work portion of a fitness evaluation, and wherein the exerciser's recovery heart rate is the difference between the exerciser's heart rate at the beginning and end of a recovery portion of the fitness evaluation. a movable element that is movable in the performance of an exercise, the movable element having at least one selectively adjustable operating parameter; and a controller that is configured to adjust the at least one selectively adjustable operating parameter of the movable element in order to increase or decrease the intensity of the exercise and thereby increase or decrease an exerciser's heart rate into one of a plurality of target heart rate zones, characterized in that each of the plurality of target heart rate zones is calculated using both an average work heart rate and a recovery heart rate of the exerciser, wherein the exerciser's average work heart rate comprises the exerciser's average heart rate during a work portion of a fitness evaluation, and wherein the exerciser's recovery heart rate is the difference between the exerciser's heart rate at the beginning and end of a recovery portion of the fitness evaluation.