A radiation detection system, comprising: a radiation detector, comprising: a semiconductor layer having a first surface and a second surface opposite the first surface; a monolithic cathode disposed on the first surface; and a plurality of pixelated anode strip-electrodes disposed on the second surface in a coplanar arrangement, wherein the plurality of pixelated anode strip-electrodes comprise a first set of pixelated anode strip-electrodes disposed along a first direction and a second set of pixelated anode strip-electrodes disposed along a second direction orthogonal to the first direction, and at least one of the first set of pixelated anode strip-electrodes or the second set of pixelated anode strip-electrodes has each pixelated anode strip-electrode comprising a respective plurality of segments (68, 112) disposed along its respective direction; an electrical connection and distribution plate (84, 118, 148) coupled to the radiation detector and configured to electrically connect the plurality of pixelated anode strip-electrodes to electronic channels, wherein the electrical connection and distribution plate (84, 118, 148) comprises a first plurality of pads (94, 128) having interconnections (96, 98, 130, 132, 134) disposed on a first plate surface (86, 120) and configured to electrically interconnect the respective plurality of segments (68, 112) for each respective pixelated anode-strip-electrode (64, 66) having the respective plurality of segments in at least one of the first set or second set of pixelated anode strip-electrodes; and processing circuitry configured to execute instructions stored on a memory to group a plurality of adjacent anode strip-electrodes from at least one of the first and second sets of pixelated anode strip-electrodes into a virtual pixel and to count a number of events corresponding to absorption of radiation photons by the semiconductor layer within the virtual pixel to the virtual pixel. a radiation detector, comprising: a semiconductor layer having a first surface and a second surface opposite the first surface; a monolithic cathode disposed on the first surface; and a plurality of pixelated anode strip-electrodes disposed on the second surface in a coplanar arrangement, wherein the plurality of pixelated anode strip-electrodes comprise a first set of pixelated anode strip-electrodes disposed along a first direction and a second set of pixelated anode strip-electrodes disposed along a second direction orthogonal to the first direction, and at least one of the first set of pixelated anode strip-electrodes or the second set of pixelated anode strip-electrodes has each pixelated anode strip-electrode comprising a respective plurality of segments (68, 112) disposed along its respective direction; a semiconductor layer having a first surface and a second surface opposite the first surface; a monolithic cathode disposed on the first surface; and a plurality of pixelated anode strip-electrodes disposed on the second surface in a coplanar arrangement, wherein the plurality of pixelated anode strip-electrodes comprise a first set of pixelated anode strip-electrodes disposed along a first direction and a second set of pixelated anode strip-electrodes disposed along a second direction orthogonal to the first direction, and at least one of the first set of pixelated anode strip-electrodes or the second set of pixelated anode strip-electrodes has each pixelated anode strip-electrode comprising a respective plurality of segments (68, 112) disposed along its respective direction; an electrical connection and distribution plate (84, 118, 148) coupled to the radiation detector and configured to electrically connect the plurality of pixelated anode strip-electrodes to electronic channels, wherein the electrical connection and distribution plate (84, 118, 148) comprises a first plurality of pads (94, 128) having interconnections (96, 98, 130, 132, 134) disposed on a first plate surface (86, 120) and configured to electrically interconnect the respective plurality of segments (68, 112) for each respective pixelated anode-strip-electrode (64, 66) having the respective plurality of segments in at least one of the first set or second set of pixelated anode strip-electrodes; and processing circuitry configured to execute instructions stored on a memory to group a plurality of adjacent anode strip-electrodes from at least one of the first and second sets of pixelated anode strip-electrodes into a virtual pixel and to count a number of events corresponding to absorption of radiation photons by the semiconductor layer within the virtual pixel to the virtual pixel.