A fluid transfer device (140; 180; 190) for use with a cartridge and a drug vial for filling the cartridge with a liquid drug dosage, the cartridge including an open ended tube having a leading cartridge end and a trailing cartridge end, the leading cartridge end sealed by a cartridge septum and the trailing cartridge end sealed by a slidable seal, the leading cartridge end having a forwardmost cartridge surface, the drug vial including a drug vial bottle containing a drug component and having a drug vial opening sealed by a drug vial stopper, the fluid transfer device (140; 180; 190) comprising: a double ended main body having a longitudinal axis and including a vial port for telescopically receiving the drug vial and having a puncturing cannula for puncturing the drug vial stopper for flow communication with the drug vial bottle and a cartridge port (144; 181; 191) having i) a puncturing needle for puncturing the cartridge septum for flow communication with the open ended tube on manual sliding insertion of the cartridge thereinto towards said vial port, said puncturing cannula being in flow communication with said puncturing needle for enabling a manual cartridge filling procedure for filling the cartridge with the liquid drug dosage, and ii) a cartridge securing arrangement (160; 183, 184; 196) for releasably securing the cartridge in said cartridge port (144; 181; 191) on said manual sliding insertion thereinto, characterised by the cartridge port further comprising iii) a cartridge ejection arrangement (160; 183, 184; 201) for at least partially ejecting the filled cartridge from said cartridge port for assisting complete sliding ejection of the filled cartridge therefrom. a double ended main body having a longitudinal axis and including a vial port for telescopically receiving the drug vial and having a puncturing cannula for puncturing the drug vial stopper for flow communication with the drug vial bottle and a cartridge port (144; 181; 191) having i) a puncturing needle for puncturing the cartridge septum for flow communication with the open ended tube on manual sliding insertion of the cartridge thereinto towards said vial port, said puncturing cannula being in flow communication with said puncturing needle for enabling a manual cartridge filling procedure for filling the cartridge with the liquid drug dosage, and ii) a cartridge securing arrangement (160; 183, 184; 196) for releasably securing the cartridge in said cartridge port (144; 181; 191) on said manual sliding insertion thereinto, characterised by the cartridge port further comprising iii) a cartridge ejection arrangement (160; 183, 184; 201) for at least partially ejecting the filled cartridge from said cartridge port for assisting complete sliding ejection of the filled cartridge therefrom. i) a puncturing needle for puncturing the cartridge septum for flow communication with the open ended tube on manual sliding insertion of the cartridge thereinto towards said vial port, said puncturing cannula being in flow communication with said puncturing needle for enabling a manual cartridge filling procedure for filling the cartridge with the liquid drug dosage, and ii) a cartridge securing arrangement (160; 183, 184; 196) for releasably securing the cartridge in said cartridge port (144; 181; 191) on said manual sliding insertion thereinto, characterised by the cartridge port further comprising iii) a cartridge ejection arrangement (160; 183, 184; 201) for at least partially ejecting the filled cartridge from said cartridge port for assisting complete sliding ejection of the filled cartridge therefrom.