A compound, a pharmaceutically acceptable salt, or a solvate thereof, wherein the compound is selected from: -N- [3-methyl-1-(3-phenyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3-methyl-1-(3-pyridinyl-3-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-phenyl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-pyridinyl-3-yl thioureido) propyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3- phenyl thioureido)-methyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-3-yl thioureido)-methyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-2-yl thioureido)-methyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[3-methyl-1-(3-pyridinyl-2-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-phenyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-pyridinyl-3-yl thioureido) butyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-pyridinyl-2-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2-methyl-1-(3-pyridinyl-2-yl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2-methyl-1-(3-phenyl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-2-yl thioureido)-methyl] cinnamamide; -N-[3-methyl-1-(3-phenyl thioureido) butyl]cinnamamide; -N-[3,3-dimethyl-1-(3-phenyl thioureido) butyl]cinnamamide; -N-[2,2-dimethyl-1-(3-phenyl thioureido) propyl] cinnamamide; -N-[cyclopropyl-(3-phenyl thioureido)-methyl]cinnamamide; -N-[2-methyl-1-(3-phenyl thioureido) propyl]cinnamamide; -N-[3-methyl-1-(3-methyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-o-methyl phenyl thioureido) propyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-o-methyl phenyl thioureido)-methyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; N-[3,3-dimethyl-1-(3-o-methyl phenyl thioureido) butyl] cinnamamide; N-[3-methyl-1-(3-o-methyl phenyl thioureido) butyl] cinnamamide; N-[2,2-dimethyl-1-(3-o-methyl phenyl thioureido) propyl] cinnamamide; N-[cyclopropyl-(3-o-methyl phenyl thioureido)-methyl] cinnamamide; -N-{1- [3-(4- methoxyphenyl) thioureido]-2-methylpropyl}-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-3-methylbutyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-2,2-dimethylpropyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-2-methylpropyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; N-[1-(3-cyclohexyl thioureido)-3-methylbutyl]cinnamamide; N-[1-(3-cyclohexyl thioureido)-2-methylpropyl]cinnamamide; and N-[1-(3-cyclohexyl thioureido)-2,2-dimethylpropyl]cinnamamide. -N- [3-methyl-1-(3-phenyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3-methyl-1-(3-pyridinyl-3-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-phenyl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-pyridinyl-3-yl thioureido) propyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3- phenyl thioureido)-methyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-3-yl thioureido)-methyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-2-yl thioureido)-methyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[3-methyl-1-(3-pyridinyl-2-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-phenyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-pyridinyl-3-yl thioureido) butyl]-3- (3,4,5-trimethoxyphenyl) acrylamide; -N-[3,3-dimethyl-1-(3-pyridinyl-2-yl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2-methyl-1-(3-pyridinyl-2-yl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2-methyl-1-(3-phenyl thioureido) propyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-pyridinyl-2-yl thioureido)-methyl] cinnamamide; -N-[3-methyl-1-(3-phenyl thioureido) butyl]cinnamamide; -N-[3,3-dimethyl-1-(3-phenyl thioureido) butyl]cinnamamide; -N-[2,2-dimethyl-1-(3-phenyl thioureido) propyl] cinnamamide; -N-[cyclopropyl-(3-phenyl thioureido)-methyl]cinnamamide; -N-[2-methyl-1-(3-phenyl thioureido) propyl]cinnamamide; -N-[3-methyl-1-(3-methyl thioureido) butyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[2,2-dimethyl-1-(3-o-methyl phenyl thioureido) propyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[cyclopropyl-(3-o-methyl phenyl thioureido)-methyl]-3-(3,4,5- trimethoxyphenyl) acrylamide; N-[3,3-dimethyl-1-(3-o-methyl phenyl thioureido) butyl] cinnamamide; N-[3-methyl-1-(3-o-methyl phenyl thioureido) butyl] cinnamamide; N-[2,2-dimethyl-1-(3-o-methyl phenyl thioureido) propyl] cinnamamide; N-[cyclopropyl-(3-o-methyl phenyl thioureido)-methyl] cinnamamide; -N-{1- [3-(4- methoxyphenyl) thioureido]-2-methylpropyl}-3-(3,4,5- trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-3-methylbutyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-2,2-dimethylpropyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; -N-[1-(3-cyclohexyl thioureido)-2-methylpropyl]-3-(3,4,5-trimethoxyphenyl) acrylamide; N-[1-(3-cyclohexyl thioureido)-3-methylbutyl]cinnamamide; N-[1-(3-cyclohexyl thioureido)-2-methylpropyl]cinnamamide; and N-[1-(3-cyclohexyl thioureido)-2,2-dimethylpropyl]cinnamamide.