A compound of the Formula 1: wherein m is an integer from 0 to 1; n is an integer for 0 to 2; R 1 is selected from alkyl, heteroalkyl, carbocyclyl, or heterocyclyl; R 1 is also selected from aryl or heteroaryl, wherein the aryl and heteroaryl may be further substituted by the groups selected from: 1) Halogen, 2) Alkoxy, 3) Amino, 4) -N C O-alkyl 5) -N SO 2 -aryl, 6) -N SO 2 -heteroaryl, 7) -N CON -aryl, 8) and -N CON -heteroaryl; R 2a, R 2b, R 2c, R 2d, R 2e, R 2f are independently selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl. R 2a and R 2b, R 2c and R 2d or R 2e and R 2f can be fused to form a 3 to 8 membered cycloalkyl or heterocyclyl ring system; X is selected from CH 2, O, S n, NR 3; R 3 is selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, -C R 4, -C OR 4, -S 2 R 4, -C NR 4 R 5, -S 2 NR 4 R 5, -C NR 4 R 5; R 4 and R 5 are independently selected from alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl or R 4 and R 5 can be fused to form a 3 to 8 membered heterocyclyl ring system; wherein alkyl represents C 1-6 alkyl; alkenyl represents C 2-6 alkenyl; alkynyl represents C 2-6 alkynyl; aryl includes 5-, 6-, and 7-membered substituted or unsubstituted single-ring aromatic groups in which each atom of the ring is carbon or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is aromatic; carbocyclyl includes a non-aromatic substituted or unsubstituted ring in which each atom of the ring is carbon or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is carbocyclic; heteroaryl includes substituted or unsubstituted aromatic 5- to 7membered ring structures whose ring structures include one to four heteroatoms or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is heteroaromatic; heterocyclyl includes substituted or unsubstituted non-aromatic 3- to 10-membered ring structures whose ring structures include one to four heteroatoms or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is heterocyclic. n is an integer for 0 to 2; R 1 is selected from alkyl, heteroalkyl, carbocyclyl, or heterocyclyl; R 1 is also selected from aryl or heteroaryl, wherein the aryl and heteroaryl may be further substituted by the groups selected from: 1) Halogen, 2) Alkoxy, 3) Amino, 4) -N C O-alkyl 5) -N SO 2 -aryl, 6) -N SO 2 -heteroaryl, 7) -N CON -aryl, 8) and -N CON -heteroaryl; 1) Halogen, 2) Alkoxy, 3) Amino, 4) -N C O-alkyl 5) -N SO 2 -aryl, 6) -N SO 2 -heteroaryl, 7) -N CON -aryl, 8) and -N CON -heteroaryl; R 2a, R 2b, R 2c, R 2d, R 2e, R 2f are independently selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl. R 2a and R 2b, R 2c and R 2d or R 2e and R 2f can be fused to form a 3 to 8 membered cycloalkyl or heterocyclyl ring system; X is selected from CH 2, O, S n, NR 3; R 3 is selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, -C R 4, -C OR 4, -S 2 R 4, -C NR 4 R 5, -S 2 NR 4 R 5, -C NR 4 R 5; R 4 and R 5 are independently selected from alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl or R 4 and R 5 can be fused to form a 3 to 8 membered heterocyclyl ring system; wherein alkyl represents C 1-6 alkyl; alkenyl represents C 2-6 alkenyl; alkynyl represents C 2-6 alkynyl; aryl includes 5-, 6-, and 7-membered substituted or unsubstituted single-ring aromatic groups in which each atom of the ring is carbon or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is aromatic; carbocyclyl includes a non-aromatic substituted or unsubstituted ring in which each atom of the ring is carbon or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is carbocyclic; heteroaryl includes substituted or unsubstituted aromatic 5- to 7membered ring structures whose ring structures include one to four heteroatoms or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is heteroaromatic; heterocyclyl includes substituted or unsubstituted non-aromatic 3- to 10-membered ring structures whose ring structures include one to four heteroatoms or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings wherein at least one of the rings is heterocyclic.