A system for delivering an aerosolized medicament to a ventilated patient, comprising: a ventilator structured to produce a flow of breathing gas; a nebulizer structured to aerosolize a medicament; a monitoring device structured to generate an output signal; and a controller operatively coupled with the ventilator, nebulizer, and monitoring device, wherein the controller is adapted to: coordinate operation of the ventilator and the nebulizer to produce a respiratory maneuver; characterized in that: the system further comprises a number of sensors arranged to be in communication with the monitoring device, the sensors being arranged to be applied to the patient to track the patient's physiological state; wherein the output signal is associated with a response of such a patient to receipt of the aerosolized medicament; and wherein the controller is further adapted to, responsive to the output signal from the monitoring device, automatically establish ventilator settings and nebulizer settings to optimize delivery of the aerosolized medicament to such patient. a ventilator structured to produce a flow of breathing gas; a nebulizer structured to aerosolize a medicament; a monitoring device structured to generate an output signal; and a controller operatively coupled with the ventilator, nebulizer, and monitoring device, wherein the controller is adapted to: coordinate operation of the ventilator and the nebulizer to produce a respiratory maneuver; characterized in that: the system further comprises a number of sensors arranged to be in communication with the monitoring device, the sensors being arranged to be applied to the patient to track the patient's physiological state; wherein the output signal is associated with a response of such a patient to receipt of the aerosolized medicament; and wherein the controller is further adapted to, responsive to the output signal from the monitoring device, automatically establish ventilator settings and nebulizer settings to optimize delivery of the aerosolized medicament to such patient. coordinate operation of the ventilator and the nebulizer to produce a respiratory maneuver; characterized in that: the system further comprises a number of sensors arranged to be in communication with the monitoring device, the sensors being arranged to be applied to the patient to track the patient's physiological state; wherein the output signal is associated with a response of such a patient to receipt of the aerosolized medicament; and wherein the controller is further adapted to, responsive to the output signal from the monitoring device, automatically establish ventilator settings and nebulizer settings to optimize delivery of the aerosolized medicament to such patient. the system further comprises a number of sensors arranged to be in communication with the monitoring device, the sensors being arranged to be applied to the patient to track the patient's physiological state; wherein the output signal is associated with a response of such a patient to receipt of the aerosolized medicament; and wherein the controller is further adapted to, responsive to the output signal from the monitoring device, automatically establish ventilator settings and nebulizer settings to optimize delivery of the aerosolized medicament to such patient.