mhurhangee/ep-ind-claims huggingface dataset:
A diode comprising: a first layer of a first conductivity type having an upper surface and a lower surface, the first layer having a resistivity between 0.01 to 0.05 ohm-cm; a second layer of a second conductivity type being provided over the upper surface of the first layer, the second layer having an upper surface and a lower surface, the lower surface of the second layer facing the upper surface of the first layer; an anode being provided proximate to the lower surface of the first layer; a cathode being provided proximate to the upper surface of the second layer; a passivation layer being provided proximate to the upper surface of the second layer; a doped region of a second conductivity type being formed at an upper portion of the second layer and contacting the cathode; and an isolation region being formed at an edge of the substrate, the isolation region extending vertically from the upper surface of the second layer to the lower surface of the second layer; characterized in that the isolation region being formed at an edge of the first layer by diffusing dopants into the second layer from the upper surface only, so that the concentration of the isolation region near the lower surface region of the second layer is less than the surface concentration of the isolation region, and the surface concentration of the isolation region is provided to be greater than 1E19 per cm 3. a first layer of a first conductivity type having an upper surface and a lower surface, the first layer having a resistivity between 0.01 to 0.05 ohm-cm; a second layer of a second conductivity type being provided over the upper surface of the first layer, the second layer having an upper surface and a lower surface, the lower surface of the second layer facing the upper surface of the first layer; an anode being provided proximate to the lower surface of the first layer; a cathode being provided proximate to the upper surface of the second layer; a passivation layer being provided proximate to the upper surface of the second layer; a doped region of a second conductivity type being formed at an upper portion of the second layer and contacting the cathode; and an isolation region being formed at an edge of the substrate, the isolation region extending vertically from the upper surface of the second layer to the lower surface of the second layer; characterized in that the isolation region being formed at an edge of the first layer by diffusing dopants into the second layer from the upper surface only, so that the concentration of the isolation region near the lower surface region of the second layer is less than the surface concentration of the isolation region, and the surface concentration of the isolation region is provided to be greater than 1E19 per cm 3.
A chemokine/chemokine receptor inhibitor for use in a method of treating an inflammatory bowel disease in a subject, the method comprising administering to the subject the chemokine/chemokine receptor inhibitor in an ingestible device, wherein the ingestible device comprises: an ingestible housing comprising a reservoir having a therapeutically effective amount of the chemokine/chemokine receptor inhibitor stored therein; a release mechanism having a closed state which retains the chemokine/chemokine receptor inhibitor in the reservoir and an open state which allows for the release of the chemokine/chemokine receptor inhibitor from the reservoir to the exterior of the device; an actuator which controls the transition of the release mechanism from the closed to the open state; a detector for detecting the location of the ingestible device in the subject's gastrointestinal tract; and a processor which is coupled to the detector and to the actuator and which triggers the actuator to cause the release mechanism to transition from its closed state to its open state to release the chemokine/chemokine receptor inhibitor in the cecum when it is determined that the ingestible device is in the cecum of the subject, wherein the site of disease is in the colon, wherein determining the location of the ingestible device in the gastrointestinal tract comprises detecting a transition of the ingestible device from the ileum to the cecum. an ingestible housing comprising a reservoir having a therapeutically effective amount of the chemokine/chemokine receptor inhibitor stored therein; a release mechanism having a closed state which retains the chemokine/chemokine receptor inhibitor in the reservoir and an open state which allows for the release of the chemokine/chemokine receptor inhibitor from the reservoir to the exterior of the device; an actuator which controls the transition of the release mechanism from the closed to the open state; a detector for detecting the location of the ingestible device in the subject's gastrointestinal tract; and a processor which is coupled to the detector and to the actuator and which triggers the actuator to cause the release mechanism to transition from its closed state to its open state to release the chemokine/chemokine receptor inhibitor in the cecum when it is determined that the ingestible device is in the cecum of the subject, wherein the site of disease is in the colon, wherein determining the location of the ingestible device in the gastrointestinal tract comprises detecting a transition of the ingestible device from the ileum to the cecum.
A mouse that has undergone immunoglobulin gene sequence rearrangement so that it expresses a B cell that comprises a rearranged immunoglobulin sequence operably linked to a mouse heavy chain constant region sequence at the endogenous immunoglobulin heavy chain locus, the rearranged immunoglobulin sequence comprising a human heavy chain V, D, and/or J sequence, the B cell and said mouse comprising in its genome an integrated Adam6 sequence that encodes a mouse ADAM6a protein or ortholog or homolog thereof that is functional in a male mouse and a mouse ADAM6b protein or ortholog or homolog thereof that is functional in a male mouse, wherein the integrated Adam6 sequence is present in the B cell on a first allele but not a second allele of the immunoglobulin heavy chain locus, wherein the B cell and said mouse lack a functional endogenous Adam6 gene.
Cooling device configured to extend circumferentially around a casing of a turbomachine, such as for example a casing of a turbine, comprising: - an axially extending support for attachment to the casing, - at least one circumferentially extending cooling tube, - at least one fixing device, comprising a radially inner portion at least partly surrounding the pipe, and a radially outer portion fixed to the support, characterised in that the radially outer portion of the fixing device is fixed to the support via a connecting member comprising a central portion having a first circumferential end portion and a second circumferential end portion which are circumferentially opposite, the first end portion and the second end portion each extending in an opposite axial direction, the first and second end portions (32, 32) each being fixed to the support, the radially outer portion of the fixing member being fixed to the central portion of the connecting member. - an axially extending support for attachment to the casing, - at least one circumferentially extending cooling tube, - at least one fixing device, comprising a radially inner portion at least partly surrounding the pipe, and a radially outer portion fixed to the support, characterised in that the radially outer portion of the fixing device is fixed to the support via a connecting member comprising a central portion having a first circumferential end portion and a second circumferential end portion which are circumferentially opposite, the first end portion and the second end portion each extending in an opposite axial direction, the first and second end portions (32, 32) each being fixed to the support, the radially outer portion of the fixing member being fixed to the central portion of the connecting member.
A refrigeration door having an outer surface and adapted for use in a refrigerating compartment (8, 9), said door comprising: a first sheet of glass; a second sheet of glass; a first sealant assembly (90 or 95) disposed around the periphery of said first sheet of glass and said second sheet of glass for maintaining said first sheet and said second sheet in spaced-apart relationship from each other; a titania/silver based low emissivity coating adjacent a surface of said first sheet and said second sheet of glass; said first sheet and second sheets of glass, said first sealant assembly (90 or 95), and said first low emissivity coating forming an insulating glass unit having a U value substantially equal to 0.2 BTU/hr-sq ft-F (1,136 W/m 2 K) when having an emissivity equal to 0,0025, a spacing between the sheets of 5/16 inches (7,94 mm), each sheet having a thickness of 1/8 inch (3,18 mm) and an emissivity of 0.05, and having krypton as gas in the spacing between the sheets, to prevent the formation of condensation on the outer surface of the refrigeration door; an anti-frost or anti-fog coating on a surface of one of the sheets of glass; and a frame secured around the periphery of said insulating glass unit. a first sheet of glass; a second sheet of glass; a first sealant assembly (90 or 95) disposed around the periphery of said first sheet of glass and said second sheet of glass for maintaining said first sheet and said second sheet in spaced-apart relationship from each other; a titania/silver based low emissivity coating adjacent a surface of said first sheet and said second sheet of glass; said first sheet and second sheets of glass, said first sealant assembly (90 or 95), and said first low emissivity coating forming an insulating glass unit having a U value substantially equal to 0.2 BTU/hr-sq ft-F (1,136 W/m 2 K) when having an emissivity equal to 0,0025, a spacing between the sheets of 5/16 inches (7,94 mm), each sheet having a thickness of 1/8 inch (3,18 mm) and an emissivity of 0.05, and having krypton as gas in the spacing between the sheets, to prevent the formation of condensation on the outer surface of the refrigeration door; an anti-frost or anti-fog coating on a surface of one of the sheets of glass; and a frame secured around the periphery of said insulating glass unit.
Method for a mobile management control entity, MBC, being adapted for communicating with an access node, AN, such as an eNodeB, the MBC being adapted for, - issuing a message comprising an indication of a type of traffic to be reduced to the AN, wherein the traffic reduction comprises one of blocking, rejecting, ignoring or selectively restricting traffic, wherein the message comprising the indication of a type of traffic to be reduced is an overload message that indicates a started overload situation, or overload situation that is risking to start, the message being transmitted to the AN, characterized in that the overload message comprises an erroneous traffic indication. - issuing a message comprising an indication of a type of traffic to be reduced to the AN, wherein the traffic reduction comprises one of blocking, rejecting, ignoring or selectively restricting traffic, wherein the message comprising the indication of a type of traffic to be reduced is an overload message that indicates a started overload situation, or overload situation that is risking to start, the message being transmitted to the AN, characterized in that the overload message comprises an erroneous traffic indication.
An electrode for an electricity-storing device, the electrode comprising: a current collector foil; an active material layer formed on at least one surface of the current collector foil; and a high electrical resistance layer formed on the at least one surface of the current collector foil so as to be adjacent to and in direct contact with the active material layer; wherein at at least a portion of an interface between the active material layer and the high electrical resistance layer, a mixed phase is formed where constituents from the two layers intermingle, and characterized in that the active material layer has a bulk zone at which thickness is constant, and a tapered zone at which thickness tapers off; and the high electrical resistance layer overlaps a portion of the tapered zone of the active material layer, but does not overlap the bulk zone of the active material layer. a current collector foil; an active material layer formed on at least one surface of the current collector foil; and a high electrical resistance layer formed on the at least one surface of the current collector foil so as to be adjacent to and in direct contact with the active material layer; wherein at at least a portion of an interface between the active material layer and the high electrical resistance layer, a mixed phase is formed where constituents from the two layers intermingle, and characterized in that the active material layer has a bulk zone at which thickness is constant, and a tapered zone at which thickness tapers off; and the high electrical resistance layer overlaps a portion of the tapered zone of the active material layer, but does not overlap the bulk zone of the active material layer.
A computer-implemented method of identifying treatment relevant neoepitopes for use in guided immunotherapy of a patient diagnosed with a tumour, comprising: receiving omics data for tumour cells in a first and second location in the patient, wherein the first and second locations are different anatomical locations, and wherein the omics data is obtained using nucleic acid sequencing, RNA sequencing, protein sequencing or mass spectroscopy based sequencing; using the omics data to determine respective neoepitopes in the tumour cells of the first and second locations; filtering the respective neoepitopes against matched normal omics data; further filtering the respective neoepitopes against an HLA-type of the patient comprising: determining the HLA-type of the patient; calculating binding affinities of the respective neoepitopes to the determined HLA-type of the patient; selecting high-affinity neoepitopes for the first and second locations that have a binding affinity to the determined HLA-type of the patient of less than 500 nM; and identifying, from the high-affinity neoepitopes in the tumour cells of the first and second locations, treatment relevant neoepitopes sharing at least one of a group attribute, a location attribute, a function attribute, a metabolic attribute, and/or a pathway attribute. receiving omics data for tumour cells in a first and second location in the patient, wherein the first and second locations are different anatomical locations, and wherein the omics data is obtained using nucleic acid sequencing, RNA sequencing, protein sequencing or mass spectroscopy based sequencing; using the omics data to determine respective neoepitopes in the tumour cells of the first and second locations; filtering the respective neoepitopes against matched normal omics data; further filtering the respective neoepitopes against an HLA-type of the patient comprising: determining the HLA-type of the patient; calculating binding affinities of the respective neoepitopes to the determined HLA-type of the patient; selecting high-affinity neoepitopes for the first and second locations that have a binding affinity to the determined HLA-type of the patient of less than 500 nM; and identifying, from the high-affinity neoepitopes in the tumour cells of the first and second locations, treatment relevant neoepitopes sharing at least one of a group attribute, a location attribute, a function attribute, a metabolic attribute, and/or a pathway attribute. determining the HLA-type of the patient; calculating binding affinities of the respective neoepitopes to the determined HLA-type of the patient; selecting high-affinity neoepitopes for the first and second locations that have a binding affinity to the determined HLA-type of the patient of less than 500 nM; and identifying, from the high-affinity neoepitopes in the tumour cells of the first and second locations, treatment relevant neoepitopes sharing at least one of a group attribute, a location attribute, a function attribute, a metabolic attribute, and/or a pathway attribute.
An electrode comprising: a current collector; and an electrode layer formed on the current collector, and comprising an electronic conductive agent and particles of an active material containing niobium-titanium composite oxide, wherein the particles of the active material comprise secondary particles in which primary particles of the active material are aggregated, an average particle size of the secondary particles measured by a Scanning Electron Microscope is within a range of 1 μm to 30 μm, and a mode diameter in a pore diameter distribution of the electrode layer obtained by mercury porosimetry is within a range of 0.1 μm to 0.2 μm. a current collector; and an electrode layer formed on the current collector, and comprising an electronic conductive agent and particles of an active material containing niobium-titanium composite oxide, wherein the particles of the active material comprise secondary particles in which primary particles of the active material are aggregated, an average particle size of the secondary particles measured by a Scanning Electron Microscope is within a range of 1 μm to 30 μm, and a mode diameter in a pore diameter distribution of the electrode layer obtained by mercury porosimetry is within a range of 0.1 μm to 0.2 μm.
A method in a first radio network node for measuring interference between the first radio network node and a second radio network node, the method comprising: obtaining (201, 901) configuration information for indicating a designated subframe in which a reference signal for measurement of the interference is to be transmitted by the second radio network node, the designated subframe being designated for enabling measurement of the interference, wherein the designated < remove carriage return here > subframe is a special subframe and comprises an uplink timeslot, a downlink timeslot and a guard period between the uplink and downlink timeslots, wherein a first downlink timeslot of the first radio network node is shorter than a second downlink timeslot of the second radio node; dynamically configuring the designated subframe in the first radio network node according to the obtained configuration information when the interference is to be measured; receiving (205, 903), from the second radio network node in the designated subframe indicated by the configuration information, the reference signal; and determining (206, 904) a value of the interference based on the reference signal. obtaining (201, 901) configuration information for indicating a designated subframe in which a reference signal for measurement of the interference is to be transmitted by the second radio network node, the designated subframe being designated for enabling measurement of the interference, wherein the designated < remove carriage return here > subframe is a special subframe and comprises an uplink timeslot, a downlink timeslot and a guard period between the uplink and downlink timeslots, wherein a first downlink timeslot of the first radio network node is shorter than a second downlink timeslot of the second radio node; dynamically configuring the designated subframe in the first radio network node according to the obtained configuration information when the interference is to be measured; receiving (205, 903), from the second radio network node in the designated subframe indicated by the configuration information, the reference signal; and determining (206, 904) a value of the interference based on the reference signal.
A method, comprising: assigning a port profile to a first port group on a virtual switch executing on a computer server hosting a plurality of virtual machine instances, wherein the port profile includes network policies; connecting a virtual network interface on each of the virtual machine instances to a respective port in the first port group; and forwarding, based on one of the network policies, network traffic addressed to one of the virtual network interfaces in the first port group to a second port group, wherein the one of the network policies comprises one or more of: a span rule specifying to copy network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group; and a redirect rule specifying to redirect network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group. assigning a port profile to a first port group on a virtual switch executing on a computer server hosting a plurality of virtual machine instances, wherein the port profile includes network policies; connecting a virtual network interface on each of the virtual machine instances to a respective port in the first port group; and forwarding, based on one of the network policies, network traffic addressed to one of the virtual network interfaces in the first port group to a second port group, wherein the one of the network policies comprises one or more of: a span rule specifying to copy network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group; and a redirect rule specifying to redirect network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group. a span rule specifying to copy network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group; and a redirect rule specifying to redirect network traffic addressed to one of the virtual network interfaces in the first port group to an active port in the second port group.