A compound or physiologically acceptable salt thereof, having the formula: wherein: R 1 = where n=0-2, and when n = 2, each occurrence of R 8 is independently selected; R 2 = -[ C(=O)NH(CH 2) n NHC(=O)] m m Z, where n = 0-30, m = 0-1, L is a linker, and Z is a benzyl amino sulfonic acid, a benzyl amino carboxylic acid, or a polyethylene glycol; R 3 = OH, -O-C(=O)-X, -NH 2, -NH-C(=O)-NHX, or -NH-C(=O)-X where n = 0-2 and X is independently selected from C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, and wherein n = 0-10, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl, and OY where Y is independently selected from H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and C 6 -C 14 aryl; R 4 = 6'sulfated GlcNAc, 6'carboxylated GlcNAc, 6'sulfated GalNAc, 6'sulfated galactose, 6'carboxylated galactose or where R 9 is aryl, heteroaryl, cyclohexane, t-butane, adamantane, or triazole, and any of R 9 may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 6 -C 14 aryl; R 5 = H, or R 4 and R 5 are taken together to form where R 10 is aryl, heteroaryl, where n = 0-10, and any one of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl; R 6 = H, fucose, mannose, arabinose, galactose or polyol; R 7 = H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl or and R 8 = H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, where n=0-3 and X is independently selected from H, OH, Cl, F, N 3, NH 2, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl, OC 1 -C 8 alkanyl, OC 2 -C 8 alkenyl, OC 2 -C 8 alkynyl, and OC 6 -C 14 aryl, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 6 -C 14 aryl. R 1 = where n=0-2, and when n = 2, each occurrence of R 8 is independently selected; R 2 = -[ C(=O)NH(CH 2) n NHC(=O)] m m Z, where n = 0-30, m = 0-1, L is a linker, and Z is a benzyl amino sulfonic acid, a benzyl amino carboxylic acid, or a polyethylene glycol; R 3 = OH, -O-C(=O)-X, -NH 2, -NH-C(=O)-NHX, or -NH-C(=O)-X where n = 0-2 and X is independently selected from C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, and wherein n = 0-10, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl, and OY where Y is independently selected from H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and C 6 -C 14 aryl; R 4 = 6'sulfated GlcNAc, 6'carboxylated GlcNAc, 6'sulfated GalNAc, 6'sulfated galactose, 6'carboxylated galactose or where R 9 is aryl, heteroaryl, cyclohexane, t-butane, adamantane, or triazole, and any of R 9 may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 6 -C 14 aryl; R 5 = H, or R 4 and R 5 are taken together to form where R 10 is aryl, heteroaryl, where n = 0-10, and any one of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl; R 6 = H, fucose, mannose, arabinose, galactose or polyol; R 7 = H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl or and R 8 = H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, where n=0-3 and X is independently selected from H, OH, Cl, F, N 3, NH 2, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl, OC 1 -C 8 alkanyl, OC 2 -C 8 alkenyl, OC 2 -C 8 alkynyl, and OC 6 -C 14 aryl, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 6 -C 14 aryl and OY where Y is H, C 1 -C 8 alkanyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or C 6 -C 14 aryl.