A drug delivery device for administering a dose of a medicament, comprising: a housing (111, 303, 415, 501, 621, 703) having a needle hub with a fluid channel; characterized in that the drug delivery device further comprising: a drug reservoir (101, 311, 421, 511, 611, 723) disposed in said housing and containing a medicament, said drug reservoir having a seal formed from a layer that is ruptured by applying a dispensing pressure to said drug reservoir, said drug reservoir having an outlet passage that merges with said fluid channel in said needle hub; a needle (135, 325, 521, 727) connected to said needle hub, said needle-having a first end in said fluid channel of said needle hub and in communication with said outlet passage of said drug reservoir, said needle having a second end extending outwardly from said needle hub, said fluid channel of said needle hub communicating with said drug reservoir, and said first end of said needle received in said outlet passage of said drug reservoir and spaced from said seal; and a pressure applying member movably connected to said housing and movable between first and second positions with respect to said drug reservoir, said pressure applying member not applying pressure to said drug reservoir in said first position and contacting and applying the dispensing pressure to said drug reservoir in said second position rupturing said seal and dispensing said medicament stored in said drug reservoir through said outlet passage of said drug reservoir to said needle, said first end of said needle being spaced from said seal of said drug reservoir defining a gap between said needle and said seal of said drug reservoir and said needle being spaced from said seal of said drug reservoir defining the gap between said needle and seal of said drug reservoir when said pressure applying member is in said second position. a housing (111, 303, 415, 501, 621, 703) having a needle hub with a fluid channel; characterized in that the drug delivery device further comprising: a drug reservoir (101, 311, 421, 511, 611, 723) disposed in said housing and containing a medicament, said drug reservoir having a seal formed from a layer that is ruptured by applying a dispensing pressure to said drug reservoir, said drug reservoir having an outlet passage that merges with said fluid channel in said needle hub; a drug reservoir (101, 311, 421, 511, 611, 723) disposed in said housing and containing a medicament, said drug reservoir having a seal formed from a layer that is ruptured by applying a dispensing pressure to said drug reservoir, said drug reservoir having an outlet passage that merges with said fluid channel in said needle hub; a needle (135, 325, 521, 727) connected to said needle hub, said needle-having a first end in said fluid channel of said needle hub and in communication with said outlet passage of said drug reservoir, said needle having a second end extending outwardly from said needle hub, said fluid channel of said needle hub communicating with said drug reservoir, and said first end of said needle received in said outlet passage of said drug reservoir and spaced from said seal; and a pressure applying member movably connected to said housing and movable between first and second positions with respect to said drug reservoir, said pressure applying member not applying pressure to said drug reservoir in said first position and contacting and applying the dispensing pressure to said drug reservoir in said second position rupturing said seal and dispensing said medicament stored in said drug reservoir through said outlet passage of said drug reservoir to said needle, said first end of said needle being spaced from said seal of said drug reservoir defining a gap between said needle and said seal of said drug reservoir and said needle being spaced from said seal of said drug reservoir defining the gap between said needle and seal of said drug reservoir when said pressure applying member is in said second position.