mhurhangee/ep-ind-claims huggingface dataset:
A guidance device for use during subretinal administration of a therapeutic agent, the guidance device comprising: an annular base, wherein a bottom surface of the annular base is configured to mirror the contour of a patient's eye, wherein the annular base is configured to be secured to a patient's eye; a lens coupling feature, wherein the lens coupling feature is configured to removably secure a viewing lens, which is operable to provide for viewing of the interior of a patient's eye through the pupil of the eye, relative to the annular base; and a guidance anchor, wherein the guidance anchor extends from the annular base, wherein a bottom surface of the guidance anchor is configured to mirror the contour of a patient's eye, wherein the guidance anchor comprises at least one guidance bore (740A, 740B, 740C, 740D) extending through the guidance anchor, wherein the at least one guidance bore (740A, 740B, 740C, 740D) is configured to receive a needle (420, 520, 620) so as to direct the needle (420, 520, 620) along a unique guidance pathway relative to a patient's eye, wherein the pathway is configured to direct the needle (420, 520, 620) into contact with a patient's eye at a predetermined angle via contact between interior surfaces of the guidance bore (740A, 740B, 740C, 740D) and an exterior surface of the needle (420, 520, 620) such that a distal end of the needle (420, 520, 620) can be advanced into the interior of a patient's eye through the sclera and the choroid to the subretinal space of the patient's eye. an annular base, wherein a bottom surface of the annular base is configured to mirror the contour of a patient's eye, wherein the annular base is configured to be secured to a patient's eye; a lens coupling feature, wherein the lens coupling feature is configured to removably secure a viewing lens, which is operable to provide for viewing of the interior of a patient's eye through the pupil of the eye, relative to the annular base; and a guidance anchor, wherein the guidance anchor extends from the annular base, wherein a bottom surface of the guidance anchor is configured to mirror the contour of a patient's eye, wherein the guidance anchor comprises at least one guidance bore (740A, 740B, 740C, 740D) extending through the guidance anchor, wherein the at least one guidance bore (740A, 740B, 740C, 740D) is configured to receive a needle (420, 520, 620) so as to direct the needle (420, 520, 620) along a unique guidance pathway relative to a patient's eye, wherein the pathway is configured to direct the needle (420, 520, 620) into contact with a patient's eye at a predetermined angle via contact between interior surfaces of the guidance bore (740A, 740B, 740C, 740D) and an exterior surface of the needle (420, 520, 620) such that a distal end of the needle (420, 520, 620) can be advanced into the interior of a patient's eye through the sclera and the choroid to the subretinal space of the patient's eye.
A tannin polymer, the polymer comprising a reaction product of a tannin, a triazine, and an acid, wherein said triazine has the formula: wherein R1, R2, and R3 are independently chosen from H, C 1 -C 5 alkyl and C 1 -C 5 hydroxylated alkyl, and wherein said polymer is dissolved or dispersed in an aqueous medium. wherein R1, R2, and R3 are independently chosen from H, C 1 -C 5 alkyl and C 1 -C 5 hydroxylated alkyl, and wherein said polymer is dissolved or dispersed in an aqueous medium.
A method of providing fiber web making furnish with filler comprising the steps of a) Providing a pipeline leading to a headbox of a fiber web machine with furnish, b) Making the furnish comprising fiber web making fibres flow towards the headbox, c) Mixing at least one retention/strength enhancing chemical with milk of lime together in an injection mixer for allowing strength enhancing/retention chemical molecules adhere to milk of lime particles, d) Introducing the at least one retention/strength enhancing chemical simultaneously together with milk of lime to the furnish, e) Providing the furnish with CO 2 before, during or after step d), and f)Allowing carbonation reaction between milk of lime and carbon dioxide to proceed in the presence of both fiber web making fibres and the at least one retention/strength enhancing chemical. a) Providing a pipeline leading to a headbox of a fiber web machine with furnish, b) Making the furnish comprising fiber web making fibres flow towards the headbox, c) Mixing at least one retention/strength enhancing chemical with milk of lime together in an injection mixer for allowing strength enhancing/retention chemical molecules adhere to milk of lime particles, d) Introducing the at least one retention/strength enhancing chemical simultaneously together with milk of lime to the furnish, e) Providing the furnish with CO 2 before, during or after step d), and f)Allowing carbonation reaction between milk of lime and carbon dioxide to proceed in the presence of both fiber web making fibres and the at least one retention/strength enhancing chemical.
A header for an agricultural vehicle, comprising: a header frame; a flexible cutter supported by said header frame and including a plurality of cutting edges; and a reel including a plurality of reel sections (121A, 121B, 121C, 121D) movably supported by said header frame, each of said reel sections (121A, 121B, 121C, 121D) including a plurality of tines (122A, 122B, 122C, 122D) and being independently movable from the other reel sections (121A, 121B, 121C, 121D); characterized in that said header further comprises: at least one rigid link (200A, 200B, 200C, 200D) connected to both said flexible cutter and one of said reel sections (121A, 121B, 121C, 121D), said at least one rigid link (200A, 200B, 200C, 200D) being configured to transmit flexing forces acting on said flexible cutter to said connected one reel section (121A, 121B, 121C, 121D) such that a substantially constant separation is maintained between said flexible cutter and said connected one reel section (121A, 121B, 121C, 121D). a header frame; a flexible cutter supported by said header frame and including a plurality of cutting edges; and a reel including a plurality of reel sections (121A, 121B, 121C, 121D) movably supported by said header frame, each of said reel sections (121A, 121B, 121C, 121D) including a plurality of tines (122A, 122B, 122C, 122D) and being independently movable from the other reel sections (121A, 121B, 121C, 121D); characterized in that said header further comprises: at least one rigid link (200A, 200B, 200C, 200D) connected to both said flexible cutter and one of said reel sections (121A, 121B, 121C, 121D), said at least one rigid link (200A, 200B, 200C, 200D) being configured to transmit flexing forces acting on said flexible cutter to said connected one reel section (121A, 121B, 121C, 121D) such that a substantially constant separation is maintained between said flexible cutter and said connected one reel section (121A, 121B, 121C, 121D).
A method for measuring the cornea of the eye with an optical coherence tomography system, said method comprising: collecting a first set of OCT data over a series of transverse locations on the cornea of the eye within a time short enough to avoid any significant motion of the cornea; processing the data collected in the first data set to generate a surface model of the cornea; collecting a second set of OCT data over a series of transverse locations on the cornea of the eye; determining one or both of the axial and transverse motion in the second data set by fitting the data in the second set to the surface model of the cornea created from the first set; creating a motion-corrected data set from the second data set using the determination of axial and transverse motion; and storing or displaying of the motion-corrected data set or information derived from the motion-corrected data set. collecting a first set of OCT data over a series of transverse locations on the cornea of the eye within a time short enough to avoid any significant motion of the cornea; processing the data collected in the first data set to generate a surface model of the cornea; collecting a second set of OCT data over a series of transverse locations on the cornea of the eye; determining one or both of the axial and transverse motion in the second data set by fitting the data in the second set to the surface model of the cornea created from the first set; creating a motion-corrected data set from the second data set using the determination of axial and transverse motion; and storing or displaying of the motion-corrected data set or information derived from the motion-corrected data set.
A method of making a hinge assembly, the method comprising the following steps of: selecting a defined motion path of a hinge assembly comprising a first hinge arm including a first gear having a first plurality of teeth, and a second hinge arm including a second gear having a second plurality of teeth arranged to mesh with the first teeth, the defined motion path during use including a translation of the second hinge arm relative to the first hinge arm; determining a first profile of the first gear along the first teeth and a second profile of the second gear along the second teeth based on the defined motion path; and connecting the first hinge arm to the second hinge arm such that as the second hinge arm during use rotates relative to the first hinge arm the interaction between the first and second teeth (21, 25) along the first and second profiles translates the second hinge arm along the defined motion path, characterized in that the first profile is different from the second profile such that the translation during use is a variable translation which occurs in that second hinge arm has a different motion relative to the first hinge arm, and the defined motion path comprises an instantaneous center of rotation path of the second hinge arm located at or near the first teeth of the first gear. selecting a defined motion path of a hinge assembly comprising a first hinge arm including a first gear having a first plurality of teeth, and a second hinge arm including a second gear having a second plurality of teeth arranged to mesh with the first teeth, the defined motion path during use including a translation of the second hinge arm relative to the first hinge arm; determining a first profile of the first gear along the first teeth and a second profile of the second gear along the second teeth based on the defined motion path; and connecting the first hinge arm to the second hinge arm such that as the second hinge arm during use rotates relative to the first hinge arm the interaction between the first and second teeth (21, 25) along the first and second profiles translates the second hinge arm along the defined motion path, characterized in that the first profile is different from the second profile such that the translation during use is a variable translation which occurs in that second hinge arm has a different motion relative to the first hinge arm, and the defined motion path comprises an instantaneous center of rotation path of the second hinge arm located at or near the first teeth of the first gear.
An apparatus for the decomposition of ammonium carbamate in a urea synthesis section of a urea stripping plant comprising a number of heat exchanger tubes between a top chamber and a bottom chamber, wherein the top chamber comprises a gas/liquid separator for receiving a mixture of gas and urea solution from a urea reactor, and wherein every heat exchanger tube is provided with a liquid distributor, the apparatus further comprising a perforated liquid distribution basket at the centre of the top chamber of the apparatus for receiving a liquid fraction discharged from said gas/liquid separator and for distributing said fraction over the cross-sectional diameter of the top chamber, thus creating a liquid level above the liquid distributors, wherein the liquid distributors are arranged for loading every heat exchanger tube with urea solution equally.
A method for grouping cam devices, each of the cam devices comprising a cam holder having a cam holder sliding contact surface; a cam slider having a cam slider sliding contact surface provided to come into sliding contact with the cam holder sliding contact surface, a cam slider cam surface; a cam driver having a cam driver cam surface provided to drive the cam slider to a predetermined process direction; wherein an abrasion loss between the cam holder sliding contact surface and the cam sliding contact surface is greater than the abrasion loss between the cam driver surface and the cam slider cam surface; the method, comprising: making a group of the cam devices, wherein the cam devices are grouped depending on the basis of width dimensions, and the design structures of the respective groups are determined; characterized in that the maximum process ability in a certain group among the groups i) is larger than the minimum process ability of an adjacent group having a larger width dimension, and ii) smaller than the maximum process ability in an adjacent group having a larger width dimension, thereby reducing the necessity of changing the cam device for the change of the process ability. a cam slider sliding contact surface provided to come into sliding contact with the cam holder sliding contact surface, a cam slider cam surface; a cam driver having a cam driver cam surface provided to drive the cam slider to a predetermined process direction; wherein an abrasion loss between the cam holder sliding contact surface and the cam sliding contact surface is greater than the abrasion loss between the cam driver surface and the cam slider cam surface; i) is larger than the minimum process ability of an adjacent group having a larger width dimension, and ii) smaller than the maximum process ability in an adjacent group having a larger width dimension,
A method of synchronizing asynchronously distributed downlink data for transmission by an item of radio equipment, said method implemented in an asynchronous-to-synchronous adaptor associated with the item of radio equipment and characterized by: generating a local Common Public Radio Interface (CPRI) clock responsive to CPRI synchronization data exchanged over an asynchronous communication link having a variable link delay; receiving the downlink data as CPRI basic frames sent asynchronously over the asynchronous communication link; buffering the CPRI basic frames in transmit order within a synchronization buffer that is clocked as a function of the local CPRI clock, including placing the received CPRI basic frames into buffer positions that impose buffer residency times on the buffered CPRI basic frames that add to their variable link delays to yield a defined static link delay common to all CPRI basic frames at a sequential output of the synchronization buffer; and clocking the CPRI basic frames sequentially out from the synchronization buffer as a function of the local CPRI clock, for synchronous transfer to said item of radio equipment, for downlink transmission. generating a local Common Public Radio Interface (CPRI) clock responsive to CPRI synchronization data exchanged over an asynchronous communication link having a variable link delay; receiving the downlink data as CPRI basic frames sent asynchronously over the asynchronous communication link; buffering the CPRI basic frames in transmit order within a synchronization buffer that is clocked as a function of the local CPRI clock, including placing the received CPRI basic frames into buffer positions that impose buffer residency times on the buffered CPRI basic frames that add to their variable link delays to yield a defined static link delay common to all CPRI basic frames at a sequential output of the synchronization buffer; and clocking the CPRI basic frames sequentially out from the synchronization buffer as a function of the local CPRI clock, for synchronous transfer to said item of radio equipment, for downlink transmission.
A device for quick splicing of a display screen comprising a left assembly and a right assembly, the left assembly and the right assembly being lockable with each other, the left assembly comprising a rotation fixing seat, a rotation angle seat, and a rotation locking mechanism, the rotation angle seat being lockable with the right assembly and being rotatably connected to the rotation fixing seat; the rotation locking mechanism being disposed between the rotation fixing seat and the rotation angle seat; when the rotation locking mechanism is unlocked, the rotation angle seat rotates relative to the rotation fixing seat; and when the rotation locking mechanism is locked, the rotation angle seat is fixedly connected to the rotation fixing seat; wherein the device for quick splicing of a display screen further comprises a step angle-adjusting and clamping mechanism, the step angle-adjusting and clamping mechanism is disposed between the rotation angle seat and the rotation fixing seat.
A fishing rope which is provided on at least part of its outer surface with a luminescent material, which fishing rope is a twined or laid rope comprising conventional yarns and one or more luminescent yarns intertwined with said conventional yarns, wherein at least part of the surface of said luminescent yarns comprise said luminescent material, and wherein said luminescent yarns comprise polyester having an improved transparency obtainable by extrusion using lower stretch ratios and/or faster cooling after extrusion than conventional yarns comprising polyester.
A system for disconnectable fastening of products on to a supporting structure comprising Velcro components to fix the products on said structure, the system comprising at least a first and a second bearing elements (1,2) where - the first bearing element comprising first fastening elements (3.1) of the Velcro components, is adapted to be fitted on the supporting structure and is shaped as flat strips, - and the second bearing element comprising second fastening elements (3.2) of the Velcro components, is adapted to be fitted on the surface of the product to be fastened and has the form of rectangular and/or square plates, characterised in that said plates are provided in the middle thereof and on their side-edges with fastening projections (6,6.1) for extending into the product to be fastened. - the first bearing element comprising first fastening elements (3.1) of the Velcro components, is adapted to be fitted on the supporting structure and is shaped as flat strips, - and the second bearing element comprising second fastening elements (3.2) of the Velcro components, is adapted to be fitted on the surface of the product to be fastened and has the form of rectangular and/or square plates,
A method for switching a millimeter wave directional link between a primary link and a backup link with a destination device, wherein one of said links is a direct link and the other is a relay link, the method comprising the following steps carried out in a source device: assessing quality of the backup link according to a feedback data packet received from the destination device via the backup link; and determining, on the basis of said quality assessment result of the backup link and on the basis of a quality assessment result of the primary link packed into said feedback data packet, whether to switch between the primary link and the backup link. assessing quality of the backup link according to a feedback data packet received from the destination device via the backup link; and determining, on the basis of said quality assessment result of the backup link and on the basis of a quality assessment result of the primary link packed into said feedback data packet, whether to switch between the primary link and the backup link.
A multispecific antibody comprising a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain specifically binds a target molecule, which is a cell surface-expressed tumor-associated antigen, and wherein the second antigen-binding domain specifically binds an internalizing effector protein, wherein E is CD63, and wherein the second antigen-binding domain has a dissociation constant K D value with E of between 2.0×10 -9 and 7.3×10 -9 M, the K D being determined by biolayer interferometry.
A method for providing an array comprising first and second regions on a substrate, comprising: (a) attaching first oligonucleotide molecules to first nucleic acid molecules immobilized in the first region via hybridization and/or ligation to generate first extended nucleic acid molecules; (b) attaching second oligonucleotide molecules to second nucleic acid molecules immobilized in the second region via hybridization and/or ligation to generate second extended nucleic acid molecules; and (c) irradiating the substrate through a mask comprising an opening corresponding to a boundary region between the first and second regions, thereby removing, blocking, or inactivating nucleic acid molecules immobilized in the boundary region, optionally wherein the boundary region comprises part of the first region and/or part of the second region, optionally wherein the attaching step of (a) and/or (b) comprises photolithography using a photoresist, a 3' or 5' photo-cleavable protective group, and/or a photo-cleavable polymer that blocks hybridization and/or ligation. (a) attaching first oligonucleotide molecules to first nucleic acid molecules immobilized in the first region via hybridization and/or ligation to generate first extended nucleic acid molecules; (b) attaching second oligonucleotide molecules to second nucleic acid molecules immobilized in the second region via hybridization and/or ligation to generate second extended nucleic acid molecules; and (c) irradiating the substrate through a mask comprising an opening corresponding to a boundary region between the first and second regions, thereby removing, blocking, or inactivating nucleic acid molecules immobilized in the boundary region, optionally wherein the boundary region comprises part of the first region and/or part of the second region, optionally wherein the attaching step of (a) and/or (b) comprises photolithography using a photoresist, a 3' or 5' photo-cleavable protective group, and/or a photo-cleavable polymer that blocks hybridization and/or ligation.
A method for controlling a gas turbine assembly comprising: a compressor in which compression of the outside air occurs for producing a flow of compressed air; a sequential combustor including a first combustor, in which combustion of a mixture of fuel and compressed air arriving from said compressor occurs for producing a flow of hot gasses, and a second combustor which is located downstream of said first combustor and in which combustion of a mixture of fuel and hot gasses arriving from said first combustor occurs; the method being characterized by comprising, on a start-up transient operating phase of the gas turbine assembly, the step of controlling the fuel mass flow-rate supplied to said first combustor on the basis of and according to a predetermined TFL1 schedule of the flame temperature inside said first combustor; said TFL1 schedule being adapted to maintain the flame temperature inside the first combustor substantially constant during the start-up transient operating phase.