A compound having the chemical structure of Formula I, or a salt, a solvate, a tautomer or a stereoisomer thereof, wherein: X 1 is -N=; Y 1 is -N= and R 3 is H; or Y 1 is -C = and R 3 is fluoro or chloro; L 1 is -CH 2 - or -C -; Cy 1 is cycloalkyl optionally substituted with one or more R 4, phenyl optionally substituted with one or more R 5, or 5 or 6 membered heteroaryl optionally substituted on an available carbon atom with one or more R 6 and optionally substituted on an available nitrogen atom with R 7; R 2 is -N(R 9a)(R 9b); each R 4 is independently selected from the group consisting of fluoro, -OH, C 1 -C 6 alkyl optionally substituted with one or more fluoro, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro; each R 5 is independently selected from the group consisting of fluoro, chloro, -O-R 10, -S-R 11, -S(O 2)-R 12, and C 1 -C 6 alkyl optionally substituted with one or more R 13; each R 6 is independently selected from the group consisting of fluoro, chloro, bromo, cycloalkyl, C 1 -C 6 alkyl optionally substituted with one or more fluoro, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro; or two R 6 bound to adjacent carbon atoms of the heteroaryl ring form a fused cycloalkyl ring; R 7 is cycloalkyl, C 1 -C 6 alkoxy or C 1 -C 6 alkyl optionally substituted with one or more fluoro; R 9a is H and R 9b is selected from the group consisting of (i) H, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or more fluoro, C 1 -C 6 alkyl substituted with C 1 -C 6 alkoxy or C 1 -C 6 alkyl substituted with hydroxyl and (ii) cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, each of which is optionally substituted with one to three members selected from C 1 -C 6 alkyl, haloalkyl, C 1 -C 6 alkoxy or fluoro; or R 9a and R 9b together with the nitrogen to which they are attached form a 5- or 6-membered ring having from 0 to 1 additional heteroatom selected from O, N or S, each of which is optionally substituted with one to three members selected from C 1 -C 6 alkyl, haloalkyl, C 1 -C 6 alkoxy or fluoro; each R 10, R 11 and R 12 are independently C 1 -C 6 alkyl optionally substituted with one or more fluoro; and each R 13 is independently selected from the group consisting of fluoro, -OH, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro. X 1 is -N=; Y 1 is -N= and R 3 is H; or Y 1 is -C = and R 3 is fluoro or chloro; L 1 is -CH 2 - or -C -; Cy 1 is cycloalkyl optionally substituted with one or more R 4, phenyl optionally substituted with one or more R 5, or 5 or 6 membered heteroaryl optionally substituted on an available carbon atom with one or more R 6 and optionally substituted on an available nitrogen atom with R 7; R 2 is -N(R 9a)(R 9b); each R 4 is independently selected from the group consisting of fluoro, -OH, C 1 -C 6 alkyl optionally substituted with one or more fluoro, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro; each R 5 is independently selected from the group consisting of fluoro, chloro, -O-R 10, -S-R 11, -S(O 2)-R 12, and C 1 -C 6 alkyl optionally substituted with one or more R 13; each R 6 is independently selected from the group consisting of fluoro, chloro, bromo, cycloalkyl, C 1 -C 6 alkyl optionally substituted with one or more fluoro, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro; or two R 6 bound to adjacent carbon atoms of the heteroaryl ring form a fused cycloalkyl ring; R 7 is cycloalkyl, C 1 -C 6 alkoxy or C 1 -C 6 alkyl optionally substituted with one or more fluoro; R 9a is H and R 9b is selected from the group consisting of (i) H, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or more fluoro, C 1 -C 6 alkyl substituted with C 1 -C 6 alkoxy or C 1 -C 6 alkyl substituted with hydroxyl and (ii) cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, each of which is optionally substituted with one to three members selected from C 1 -C 6 alkyl, haloalkyl, C 1 -C 6 alkoxy or fluoro; or R 9a and R 9b together with the nitrogen to which they are attached form a 5- or 6-membered ring having from 0 to 1 additional heteroatom selected from O, N or S, each of which is optionally substituted with one to three members selected from C 1 -C 6 alkyl, haloalkyl, C 1 -C 6 alkoxy or fluoro; each R 10, R 11 and R 12 are independently C 1 -C 6 alkyl optionally substituted with one or more fluoro; and each R 13 is independently selected from the group consisting of fluoro, -OH, and C 1 -C 6 alkoxy optionally substituted with one or more fluoro.