Cryptophycin compound of formula: wherein: ▪ R 1 represents a (C 1 -C 6)alkyl group; ▪ R 2 and R 3 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group; or alternatively R 2 and R 3 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl or a (C 3 -C 6)heterocycloalkyl group; ▪ R 4 and R 5 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkyl-NH(R 12) group or a (C 1 -C 6)alkyl-OH group or a (C 1 -C 6)alkyl-SH group or a (C 1 -C 6)alkyl-CO 2 H group; or alternatively R 4 and R 5 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl or a (C 3 -C 6)heterocycloalkyl group; ▪ R 6 represents a hydrogen atom or a (C 1 -C 6)alkyl group; ▪ R 7 and R 8 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkyl-CO 2 H group or a (C 1 -C 6)alkyl-N(C 1 -C 6)alkyl 2 group; or alternatively R 7 and R 8 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl group or a (C 3 -C 6)heterocycloalkyl group; ▪ R 9 represents one or more substituents of the phenyl nucleus chosen, independently of each other, from: a hydrogen atom, -OH, (C 1 -C 4)alkoxy, a halogen atom, -NH 2, -NH(C 1 -C 6)alkyl or - N(C 1 -C 6)alkyl 2 or -NH(C 1 -C 6)cycloalkyl or (C 3 -C 6)heterocycloalkyl; ▪ R 10 represents at least one substituent of the phenyl nucleus chosen from a hydrogen atom and (C 1 -C 4)alkyl; ▪ W represents • (C 1 -C 6)alkyl-NH(R 11), • (C 1 -C 6)alkyl-OH, • (C 1 -C 6)alkyl-SH, • CO 2 H or C(=O)NH 2; • (C 1 -C 6)alkyl-CO 2 H or (C 1 -C 6)alkyl-C(=O)NH 2; or • (C 1 -C 6)alkyl-N 3. ▪ R 11 and R 12 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group. ▪ R 1 represents a (C 1 -C 6)alkyl group; ▪ R 2 and R 3 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group; or alternatively R 2 and R 3 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl or a (C 3 -C 6)heterocycloalkyl group; ▪ R 4 and R 5 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkyl-NH(R 12) group or a (C 1 -C 6)alkyl-OH group or a (C 1 -C 6)alkyl-SH group or a (C 1 -C 6)alkyl-CO 2 H group; or alternatively R 4 and R 5 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl or a (C 3 -C 6)heterocycloalkyl group; ▪ R 6 represents a hydrogen atom or a (C 1 -C 6)alkyl group; ▪ R 7 and R 8 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group or a (C 1 -C 6)alkyl-CO 2 H group or a (C 1 -C 6)alkyl-N(C 1 -C 6)alkyl 2 group; or alternatively R 7 and R 8 form together with the carbon atom to which they are attached a (C 3 -C 6)cycloalkyl group or a (C 3 -C 6)heterocycloalkyl group; ▪ R 9 represents one or more substituents of the phenyl nucleus chosen, independently of each other, from: a hydrogen atom, -OH, (C 1 -C 4)alkoxy, a halogen atom, -NH 2, -NH(C 1 -C 6)alkyl or - N(C 1 -C 6)alkyl 2 or -NH(C 1 -C 6)cycloalkyl or (C 3 -C 6)heterocycloalkyl; ▪ R 10 represents at least one substituent of the phenyl nucleus chosen from a hydrogen atom and (C 1 -C 4)alkyl; ▪ W represents • (C 1 -C 6)alkyl-NH(R 11), • (C 1 -C 6)alkyl-OH, • (C 1 -C 6)alkyl-SH, • CO 2 H or C(=O)NH 2; • (C 1 -C 6)alkyl-CO 2 H or (C 1 -C 6)alkyl-C(=O)NH 2; or • (C 1 -C 6)alkyl-N 3. • (C 1 -C 6)alkyl-NH(R 11), • (C 1 -C 6)alkyl-OH, • (C 1 -C 6)alkyl-SH, • CO 2 H or C(=O)NH 2; • (C 1 -C 6)alkyl-CO 2 H or (C 1 -C 6)alkyl-C(=O)NH 2; or • (C 1 -C 6)alkyl-N 3. ▪ R 11 and R 12 represent, independently of each other, a hydrogen atom or a (C 1 -C 6)alkyl group.