mhurhangee/ep-ind-claims huggingface dataset:
A method of making a mutant Cas9 protein comprising identifying one or more amino acid sequences that are not highly conserved or have low conservation within a family of Cas9 proteins, wherein the one or more amino acid sequences that are not highly conserved or have low conservation are identified by obtaining a sequence alignment of multiple Cas9 amino acid sequences, and by identifying stretches of low conservation or stretches between conservation edges, wherein the conservation of said amino acid sequences is calculated as the relative entropy of amino acid frequencies per position, identifying a nucleic acid sequence encoding the one or more identified amino acid sequences, generating a nucleic acid sequence encoding a target Cas9 protein which lacks the nucleic acid sequence encoding the one or more identified amino acid sequences, and generating a mutant Cas9 protein from the generated nucleic acid sequence, wherein the mutant Cas9 protein retains DNA binding activity.
A façade cladding fastening system comprising, - at least two first profiles arranged to be fastened to the wall of a building, - at least two second profiles fastened to the first profiles, wherein one of the second profiles is fastened to one of the first profiles with an adjusting member, wherein the adjusting member, having a central axis perpendicular to the first and second profiles, is configured to - slide along the first profile and/or the second profile for adjusting the position of the second profile in relation to the first profile, and - move along its central axis relative to one of the first profiles or second profiles for adjusting the distance between the first and the second profile, wherein the first profile comprises a C-rail portions extending towards the second profile, characterized in that, the adjusting member comprises an adjusting portion having threads engaged with first profile flanges of the C-rail portions of the first profile, and it is configured to move along its central axis when adjusting member is rotated around the central axis. - at least two first profiles arranged to be fastened to the wall of a building, - at least two second profiles fastened to the first profiles, wherein one of the second profiles is fastened to one of the first profiles with an adjusting member, wherein the adjusting member, having a central axis perpendicular to the first and second profiles, is configured to - slide along the first profile and/or the second profile for adjusting the position of the second profile in relation to the first profile, and - move along its central axis relative to one of the first profiles or second profiles for adjusting the distance between the first and the second profile, wherein the first profile comprises a C-rail portions extending towards the second profile, characterized in that, the adjusting member comprises an adjusting portion having threads engaged with first profile flanges of the C-rail portions of the first profile, and it is configured to move along its central axis when adjusting member is rotated around the central axis.
A thermal spraying material for the coating of a surface of a workpiece by means of a thermal spraying method, wherein the spraying material contains zinc, and Sn is contained in the spray powder as an alloy element with a proportion of up to 10% by weight, in particular up to 5% by weight, especially between 1% and 4% by weight, characterised in that the spraying material is a zinc alloy and/or an intermetallic compound and/or a metallic compound and/or a non metallic compound of the kind Zn-X, wherein X is at least a metallic or a non-metallic component, Zn is contained in the range of 70% by weight to 100% by weight, preferably with more than 80% by weight, and wherein X is at least one element from the group consisting of the elements Sn, Mg, Ca, Al, Fe, Ni, Co, Cu, Mo, Ti, Cr, Zr, Y, La, Ce, Sc, Pr, Dy, Dg, C, O, N in particular a MCrAlY alloy, wherein M=Ni, Co, CoNi or Fe.
A method for one-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero, and wherein the solution introduced into the liquid chromatography stationary phase is subjected to a temperature gradient, or the solution is subjected to a solvent gradient and a temperature gradient.
A stable pharmaceutical or dermo-cosmetic aqueous solution comprising: - 13- 107 mg/ml of epigallocatechin gallate, - At least one disaccharide, - 0.1-1.0 mmol/l of at least one chelating agent, - A pharmaceutically acceptable or dermo-cosmetically acceptable pH-modifying agent, wherein said solution is at a pH in a range of 3.0 to 4.0 and the molar ratio of epigallocatechin gallate/disaccharide is from 0.1 to 0.8, particularly 0.25. - 13- 107 mg/ml of epigallocatechin gallate, - At least one disaccharide, - 0.1-1.0 mmol/l of at least one chelating agent, - A pharmaceutically acceptable or dermo-cosmetically acceptable pH-modifying agent,
A resin composition comprising: an olefin-based polymer; cellulose fibers; an amide compound having at least one hydrocarbon group, wherein the number of carbon atoms in the amide compound is 3 to 30; and an acrylic-based polymer that contains a first structural unit based on an alkyl (meth)acrylate and a second structural unit based on an acrylic monomer having an amido group and has a weight average molecular weight of 5,000 to 100,000. an olefin-based polymer; cellulose fibers; an amide compound having at least one hydrocarbon group, wherein the number of carbon atoms in the amide compound is 3 to 30; and an acrylic-based polymer that contains a first structural unit based on an alkyl (meth)acrylate and a second structural unit based on an acrylic monomer having an amido group and has a weight average molecular weight of 5,000 to 100,000.
A non-dairy drink comprising a protein component consisting of a mixture of pea proteins and hydrolysed rice proteins and optionally free amino acids wherein the pea proteins are present in an amount of 10 to 90 wt%, based on the total weight of the protein component; wherein the protein component consists of pea proteins and hydrolysed rice proteins.
A medical system for determining prospective heart failure hospitalization risk, the system comprising: (a) means for counting detected data observations acquired from a device memory in the current evaluation period for a current evaluation total amount and counting detected data observations in the preceding evaluation period for a preceding evaluation period total amount; (c) means for associating the current evaluation and preceding evaluation total amounts with a lookup table to acquire prospective risk of heart failure hospitalization, HFH, for the preceding evaluation period and the current evaluation period; (d) means for employing weighted sums of the prospective risk of HFH for the preceding evaluation period and the current evaluation period to calculate a weighted prospective risk of HFH for a patient; and (e) means for displaying on a graphical user interface the weighted prospective risk of HFH for the patient, wherein the lookup table comprises a set of data observations categories and for each said category a prospective risk of HFH, wherein each said data observations category defines a total number of group data evaluation periods each having a defined same number or falling within a same range of numbers of data observations from a population of patients therein, and wherein the prospective risk of HFH for each said data observations category is estimated as a ratio of the number of data evaluation periods of the said data observations category in which at least one HFH had occurred to the total number of group evaluation periods within the said data observation category. (a) means for counting detected data observations acquired from a device memory in the current evaluation period for a current evaluation total amount and counting detected data observations in the preceding evaluation period for a preceding evaluation period total amount; (c) means for associating the current evaluation and preceding evaluation total amounts with a lookup table to acquire prospective risk of heart failure hospitalization, HFH, for the preceding evaluation period and the current evaluation period; (d) means for employing weighted sums of the prospective risk of HFH for the preceding evaluation period and the current evaluation period to calculate a weighted prospective risk of HFH for a patient; and (e) means for displaying on a graphical user interface the weighted prospective risk of HFH for the patient, wherein the lookup table comprises a set of data observations categories and for each said category a prospective risk of HFH, wherein each said data observations category defines a total number of group data evaluation periods each having a defined same number or falling within a same range of numbers of data observations from a population of patients therein, and wherein the prospective risk of HFH for each said data observations category is estimated as a ratio of the number of data evaluation periods of the said data observations category in which at least one HFH had occurred to the total number of group evaluation periods within the said data observation category.
A system for detecting gunshots, the system comprising: gunshot sensor units for detecting gunshots, each of the gunshot sensor units comprising one or more microphones for generating audio data depicting ambient noise; and ambient noise models for the gunshot sensor units that represent ambient noise captured by the gunshot sensor units during normal conditions, wherein each gunshot sensor unit has a respective ambient noise model representing the typical ambient noise at the location of the gunshot unit, and wherein the system is configured to detect acoustic anomalies by processing current audio data against the ambient noise models. gunshot sensor units for detecting gunshots, each of the gunshot sensor units comprising one or more microphones for generating audio data depicting ambient noise; and ambient noise models for the gunshot sensor units that represent ambient noise captured by the gunshot sensor units during normal conditions, wherein each gunshot sensor unit has a respective ambient noise model representing the typical ambient noise at the location of the gunshot unit, and wherein the system is configured to detect acoustic anomalies by processing current audio data against the ambient noise models.
Dual image system, suitable for use in oncological diagnoses and real time guided biopsies, that comprises: - an ultrasound imaging device for obtaining associated signals with one or more anatomical images; - a gamma ray detector for obtaining associated signals with one or more functional images; - an electronic module for processing signals obtained by the ultrasound imaging device and by the gamma ray detector; - a casing housing an ultrasound imaging device and a gamma ray detector; and characterized in that: - the gamma ray detector is a gamma ray Compton scattering detector, comprising at least two gamma ray detection regions, substantially aligned in the same detection direction; - the ultrasound imaging device and the gamma ray detector comprise detection surfaces forming an angle between 0 and 90 degrees; - the gamma ray detection regions of the Compton scattering detector comprise at least two individual gamma ray detectors (2a, 2b) equipped with a plurality of scintillation crystals for the detection of gamma radiation, and a plurality of semiconductor photomultipliers to amplify the signal detected by said scintillation crystals. - an ultrasound imaging device for obtaining associated signals with one or more anatomical images; - a gamma ray detector for obtaining associated signals with one or more functional images; - an electronic module for processing signals obtained by the ultrasound imaging device and by the gamma ray detector; - a casing housing an ultrasound imaging device and a gamma ray detector; - the gamma ray detector is a gamma ray Compton scattering detector, comprising at least two gamma ray detection regions, substantially aligned in the same detection direction; - the ultrasound imaging device and the gamma ray detector comprise detection surfaces forming an angle between 0 and 90 degrees; - the gamma ray detection regions of the Compton scattering detector comprise at least two individual gamma ray detectors (2a, 2b) equipped with a plurality of scintillation crystals for the detection of gamma radiation, and a plurality of semiconductor photomultipliers to amplify the signal detected by said scintillation crystals.
A method of manufacturing an optical apparatus, the method comprising: depositing an optical functional layer material on a semiconductor layer in a first temperature range; forming a micro-heater on the optical functional layer material; locally heat-treating the optical functional layer material in a second temperature range, which is higher than the first temperature range, by applying current to the micro-heater; and removing the micro-heater, wherein the optical functional layer material comprises a phase change material that has a first refractive index during heat treatment in the first temperature range and has a second refractive index, which is higher than the first refractive index, during heat treatment in the second temperature range that is higher than the first temperature range, characterized in that the forming of the micro-heater comprises: forming an insulating layer on the optical functional layer material; forming a conductive metal layer material on the insulating layer; and forming a conductive metal layer by patterning the conductive metal layer material by using wet etching, wherein a portion of the insulating layer that is disposed under the conductive metal layer is removed during the patterning of the conductive metal layer material to expose the optical functional layer material to to-the patterned conductive metal layer. depositing an optical functional layer material on a semiconductor layer in a first temperature range; forming a micro-heater on the optical functional layer material; locally heat-treating the optical functional layer material in a second temperature range, which is higher than the first temperature range, by applying current to the micro-heater; and removing the micro-heater, wherein the optical functional layer material comprises a phase change material that has a first refractive index during heat treatment in the first temperature range and has a second refractive index, which is higher than the first refractive index, during heat treatment in the second temperature range that is higher than the first temperature range, characterized in that the forming of the micro-heater comprises: forming an insulating layer on the optical functional layer material; forming a conductive metal layer material on the insulating layer; and forming a conductive metal layer by patterning the conductive metal layer material by using wet etching, forming an insulating layer on the optical functional layer material; forming a conductive metal layer material on the insulating layer; and forming a conductive metal layer by patterning the conductive metal layer material by using wet etching, wherein a portion of the insulating layer that is disposed under the conductive metal layer is removed during the patterning of the conductive metal layer material to expose the optical functional layer material to to-the patterned conductive metal layer.
A method of determining a fault type in a multi-phase power grid, the method comprising: receiving phase and magnitude data for each phase in the multi-phase power grid, wherein the phase and magnitude data is indicative of a fault on the multi-phase power grid, the method characterized by: comparing the phase and magnitude data for each phase in the multi-phase power grid to a first set of predetermined criteria, wherein the first set of criteria includes predetermined inter-phasor angle criteria and predetermined relative inter-phasor angle change criteria; and determining a fault type based on the comparison of the phase and magnitude data for each phase in the multi-phase power grid to the first set of predetermined criteria. receiving phase and magnitude data for each phase in the multi-phase power grid, wherein the phase and magnitude data is indicative of a fault on the multi-phase power grid, comparing the phase and magnitude data for each phase in the multi-phase power grid to a first set of predetermined criteria, wherein the first set of criteria includes predetermined inter-phasor angle criteria and predetermined relative inter-phasor angle change criteria; and determining a fault type based on the comparison of the phase and magnitude data for each phase in the multi-phase power grid to the first set of predetermined criteria.
A calibration system for calibrating a pressure output of a drive member of a fluid injector, the calibration system comprising: a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a sensor connected to the compressible member, characterised in that the calibration system further comprises a compressible member connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; wherein the sensor is configured for measuring a force imparted by the drive member when the compressible member is in the second, at least partially compressed position. a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a sensor connected to the compressible member, characterised in that the calibration system further comprises a compressible member connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; wherein the sensor is configured for measuring a force imparted by the drive member when the compressible member is in the second, at least partially compressed position.
A data processing apparatus comprising: a cache to store a plurality of translation entries, each translation entry corresponding to one of a plurality of page table entries and defining a translation between a first address and a second address, and to encode control information indicative of an attribute of each page table entry; and translation circuitry to, in response to a lookup querying a first lookup address, return a corresponding second address when the first lookup address corresponds to one of the plurality of translation entries stored in the cache, characterised in that the translation circuitry is responsive to notification of a modification of the attribute in a page table entry corresponding to at least one translation entry already present in the cache to: modify at least some of the control information associated with the at least one translation entry; and retain the at least one translation entry corresponding to the page table entry in the cache for use in a subsequent address lookup querying the first lookup address. a cache to store a plurality of translation entries, each translation entry corresponding to one of a plurality of page table entries and defining a translation between a first address and a second address, and to encode control information indicative of an attribute of each page table entry; and translation circuitry to, in response to a lookup querying a first lookup address, return a corresponding second address when the first lookup address corresponds to one of the plurality of translation entries stored in the cache, characterised in that the translation circuitry is responsive to notification of a modification of the attribute in a page table entry corresponding to at least one translation entry already present in the cache to: modify at least some of the control information associated with the at least one translation entry; and retain the at least one translation entry corresponding to the page table entry in the cache for use in a subsequent address lookup querying the first lookup address. modify at least some of the control information associated with the at least one translation entry; and retain the at least one translation entry corresponding to the page table entry in the cache for use in a subsequent address lookup querying the first lookup address.
Glow plug having a ceramic cartridge with a heating filament linked to the ground by the body of the plug, - a central electrode passing through the tubular body to be linked to the connection of the heating filament, the rear end of the electrode being linked to a connection end-fitting for the electrical power supply and the electrode passing in an insulated manner through the metal body, - a connection member consisting of a conductive helical winding, being fitted onto the front end of the central electrode and onto the rear end of the cartridge, glow plug characterized in that - the rear end of the cartridge has a reduction with metallized surface to which is linked the connection of the heating filament, and - the connection member consisting of a helically wound metal tape having, at rest, an internal diameter (Do) less than the diameter (Dr) of the reduction is fitted onto the metallized surface of the reduction. - a central electrode passing through the tubular body to be linked to the connection of the heating filament, the rear end of the electrode being linked to a connection end-fitting for the electrical power supply and the electrode passing in an insulated manner through the metal body, - a connection member consisting of a conductive helical winding, being fitted onto the front end of the central electrode and onto the rear end of the cartridge, glow plug characterized in that - the rear end of the cartridge has a reduction with metallized surface to which is linked the connection of the heating filament, and - the connection member consisting of a helically wound metal tape having, at rest, an internal diameter (Do) less than the diameter (Dr) of the reduction is fitted onto the metallized surface of the reduction.