A compound of Formula 2: and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs selected from acetate, formate and benzoate derivatives of alcohol or amine groups, and mixtures thereof, wherein R is chosen from optionally substituted aryl and optionally substituted heteroaryl; M is a covalent bond Q is chosen from wherein R 10 and R 11 are independently chosen from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 12, R 13, R 14, and R 15 are each independently chosen from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, phenyl, substituted phenyl chosen from mono-, di-, and tri-substituted phenyl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl), heteroaryl, and substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroallcyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl); and Z is chosen from meta-phenylene and meta-phenylene substituted with a group chosen from optionally substituted alkyl having one to four carbons, optionally substituted alkoxy having one to four carbons, halo, and hydroxy; and is wherein Y is chosen from N and CR 21; and R 16, R 21, and R 22 are independently chosen from hydrogen and optionally substituted alkyl having one to four carbons; and D is NHR 9 wherein R 9 is chosen from optionally substituted aryl and optionally substituted heteroaryl. R is chosen from optionally substituted aryl and optionally substituted heteroaryl; M is a covalent bond Q is chosen from wherein R 10 and R 11 are independently chosen from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 12, R 13, R 14, and R 15 are each independently chosen from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, phenyl, substituted phenyl chosen from mono-, di-, and tri-substituted phenyl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl), heteroaryl, and substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroallcyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl); and R 10 and R 11 are independently chosen from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl; and R 12, R 13, R 14, and R 15 are each independently chosen from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, phenyl, substituted phenyl chosen from mono-, di-, and tri-substituted phenyl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroalkyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl), heteroaryl, and substituted heteroaryl chosen from mono-, di-, and tri-substituted heteroaryl wherein the substituents are independently chosen from hydroxy, nitro, cyano, amino, halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 1 -C 6 alkyloxy)C 1 -C 6 alkoxy, C 1 -C 6 perfluoroallcyl, C 1 -C 6 perfluoroalkoxy, mono-(C 1 -C 6 alkyl)amino, di(C 1 -C 6 alkyl)amino, and amino(C 1 -C 6 alkyl); and Z is chosen from meta-phenylene and meta-phenylene substituted with a group chosen from optionally substituted alkyl having one to four carbons, optionally substituted alkoxy having one to four carbons, halo, and hydroxy; and is wherein Y is chosen from N and CR 21; and R 16, R 21, and R 22 are independently chosen from hydrogen and optionally substituted alkyl having one to four carbons; and D is NHR 9 wherein R 9 is chosen from optionally substituted aryl and optionally substituted heteroaryl.