A suture clip deployment device (2; 200) for successively deploying a plurality of preloaded suture clips (18; 272) onto sutures (70; 216), comprising: a proximal handle portion (4; 202) comprising an actuation mechanism; a mandrel (16; 264) having an inner lumen (44; 274) for receiving sutures (70; 216), a proximal end portion coupled to the actuation mechanism, and a distal end portion having a distal opening (46; 276) in communication with the inner lumen (44; 274), wherein the mandrel (16; 264) defines an axial dimension extending between the distal end portion and the proximal end portion, and a radial dimension perpendicular to the axial dimension, and wherein the mandrel (16; 264) is configured to receive at least one suture (70; 216) extending through the distal opening (46; 276) and into the inner lumen (44; 274); wherein a plurality of annular suture clips (18; 272) is mountable around the distal end portion of the mandrel (16; 264), the annular suture clips (18; 272) being generally disk shaped and, when mounted around the mandrel (16; 264), having a diameter oriented in the radial dimension and a thickness oriented in the axial dimension, wherein the thickness is smaller than the diameter; characterized by a retainer (14; 262) positioned at least partially around the mandrel (16; 264) and coupled to the actuation mechanism independently of the mandrel (16; 264), the retainer (14; 262) configured to restrict the suture clips (18; 272) from moving proximally relative to the handle portion (4; 202) when the mandrel (16; 264) moves proximally relative to the handle portion (4; 202); wherein the actuation mechanism is configured to cause the mandrel (16; 264) to move proximally relative to the suture clips (18; 272), such that a distal-most one of the suture clips (18; 272) slides off of a distal end of the mandrel (16; 264) and onto one or more sutures (70; 216) extending into the distal opening (46; 276) of the mandrel (16; 264); and wherein, after the distal-most one of the suture clips (18; 272) is deployed onto one or more sutures (70; 216), the actuation mechanism is configured to cause the mandrel (16; 264) and a remaining portion of the suture clips (18; 272) to move distally relative to the handle portion (4; 202) such that a distal-most one of the remaining portion of the suture clips (18; 272) is ready to be successively deployed. a proximal handle portion (4; 202) comprising an actuation mechanism; a mandrel (16; 264) having an inner lumen (44; 274) for receiving sutures (70; 216), a proximal end portion coupled to the actuation mechanism, and a distal end portion having a distal opening (46; 276) in communication with the inner lumen (44; 274), wherein the mandrel (16; 264) defines an axial dimension extending between the distal end portion and the proximal end portion, and a radial dimension perpendicular to the axial dimension, and wherein the mandrel (16; 264) is configured to receive at least one suture (70; 216) extending through the distal opening (46; 276) and into the inner lumen (44; 274); wherein a plurality of annular suture clips (18; 272) is mountable around the distal end portion of the mandrel (16; 264), the annular suture clips (18; 272) being generally disk shaped and, when mounted around the mandrel (16; 264), having a diameter oriented in the radial dimension and a thickness oriented in the axial dimension, wherein the thickness is smaller than the diameter; characterized by a retainer (14; 262) positioned at least partially around the mandrel (16; 264) and coupled to the actuation mechanism independently of the mandrel (16; 264), the retainer (14; 262) configured to restrict the suture clips (18; 272) from moving proximally relative to the handle portion (4; 202) when the mandrel (16; 264) moves proximally relative to the handle portion (4; 202); wherein the actuation mechanism is configured to cause the mandrel (16; 264) to move proximally relative to the suture clips (18; 272), such that a distal-most one of the suture clips (18; 272) slides off of a distal end of the mandrel (16; 264) and onto one or more sutures (70; 216) extending into the distal opening (46; 276) of the mandrel (16; 264); and wherein, after the distal-most one of the suture clips (18; 272) is deployed onto one or more sutures (70; 216), the actuation mechanism is configured to cause the mandrel (16; 264) and a remaining portion of the suture clips (18; 272) to move distally relative to the handle portion (4; 202) such that a distal-most one of the remaining portion of the suture clips (18; 272) is ready to be successively deployed.