mhurhangee/ep-ind-claims huggingface dataset:
A method for forming a conjugate of two or more molecules, comprising: reacting a hydrazide thiol linker, wherein the hydrazide thiol linker compound has the formula: wherein m = 2 to 50, R 2 is H, -CONHNH 2, or -CO-A-CONHNH 2, where A is a divalent group having between 1 and 100 carbon atoms, and X and Y are independently a bond or a divalent group having 1 to 20 carbons, with a first molecule having a hydrazide-reactive group to form a thiolated first molecule, wherein reacting the hydrazide thiol linker with the first molecule comprises reacting under conditions where a thiol group of the hydrazide thiol linker is substantially present in its neutral acid form; and reacting the thiolated first molecule with a second molecule, the second molecule having a thiol-reactive group, to form the conjugate, wherein the hydrazide-reactive group of the first molecule comprises an aldehyde group, and wherein the first molecule comprises a glycosylated molecule and the aldehyde group is introduced to the first molecule by oxidation of a glycosylated portion of the first molecule. reacting a hydrazide thiol linker, wherein the hydrazide thiol linker compound has the formula: wherein m = 2 to 50, R 2 is H, -CONHNH 2, or -CO-A-CONHNH 2, where A is a divalent group having between 1 and 100 carbon atoms, and X and Y are independently a bond or a divalent group having 1 to 20 carbons, with a first molecule having a hydrazide-reactive group to form a thiolated first molecule, wherein reacting the hydrazide thiol linker with the first molecule comprises reacting under conditions where a thiol group of the hydrazide thiol linker is substantially present in its neutral acid form; and reacting the thiolated first molecule with a second molecule, the second molecule having a thiol-reactive group, to form the conjugate, wherein the hydrazide-reactive group of the first molecule comprises an aldehyde group, and wherein the first molecule comprises a glycosylated molecule and the aldehyde group is introduced to the first molecule by oxidation of a glycosylated portion of the first molecule.
A mobile device (102; 200; 302) having a processor (220; 312), comprising: an accelerometer (110; 260; 308) configured to generate acceleration data, the acceleration data comprising a plurality of acceleration measurements taken using a plurality of sampling rates that are dynamically determined based on movements of the mobile device; a memory (230; 316) having embodied thereon computer-executable instructions that are configured to, when executed by the processor (220; 312), cause the processor (220; 312) to: obtain the acceleration data from the accelerometer (110; 260; 308); perform a data interpolation process on the acceleration data to generate standardized acceleration data having a fixed sampling rate; and generate, based on the standardized acceleration data, heart sound data comprising data associated with one or more heart sounds. an accelerometer (110; 260; 308) configured to generate acceleration data, the acceleration data comprising a plurality of acceleration measurements taken using a plurality of sampling rates that are dynamically determined based on movements of the mobile device; a memory (230; 316) having embodied thereon computer-executable instructions that are configured to, when executed by the processor (220; 312), cause the processor (220; 312) to: obtain the acceleration data from the accelerometer (110; 260; 308); perform a data interpolation process on the acceleration data to generate standardized acceleration data having a fixed sampling rate; and generate, based on the standardized acceleration data, heart sound data comprising data associated with one or more heart sounds. obtain the acceleration data from the accelerometer (110; 260; 308); perform a data interpolation process on the acceleration data to generate standardized acceleration data having a fixed sampling rate; and generate, based on the standardized acceleration data, heart sound data comprising data associated with one or more heart sounds.
A security system to restrict unauthorized removal of an article from an area, said security system comprising: a security tag assembly comprising a tag component structured for attachment to the article and including a housing; an RFID component comprising an RFID label secured in overlying, substantially conforming relation to an interior surface of said housing; said tag component including a cover member disposed in overlying relation to said RFID label and in at least partially covering relation to said interior surface of said housing; characterized in that said cover member comprises one or more slots configured to provide snap-fit or like attachment to said RFID label, and in that said security tag assembly further comprises a base removably connectable to said housing, each of said base and said housing cooperatively structured for removable attachment to the article when connected to one another. a security tag assembly comprising a tag component structured for attachment to the article and including a housing; an RFID component comprising an RFID label secured in overlying, substantially conforming relation to an interior surface of said housing; said tag component including a cover member disposed in overlying relation to said RFID label and in at least partially covering relation to said interior surface of said housing; characterized in that said cover member comprises one or more slots configured to provide snap-fit or like attachment to said RFID label, and in that said security tag assembly further comprises a base removably connectable to said housing, each of said base and said housing cooperatively structured for removable attachment to the article when connected to one another.
Balloon catheter for delivery of medication comprising a balloon, characterized in that that the balloon consists of a material selected from polyamides, polyamide-blends and copolymers, polyethylene terephthalate, polyethylene and copolymers, polyurethane, and natural rubber, and in that the surface of the balloon has a coating, obtainable by applying a solution consisting of a drug and a solvent onto the surface of the balloon, and vaporizing the solvent.
A pulley assembly for use in an automobile accessory drive system, the pulley assembly comprising: a shaft engaging hub including an axis of rotation, an outer threaded surface, and a bore for receiving an accessory input shaft for engagement therewith; a pulley member including a bore that receives the shaft engaging hub, the pulley member including an inner coupling surface and an outer peripheral belt-engaging surface; a nut including an inner threaded surface that is engaged with the outer threaded surface of the shaft engaging hub, the nut having a frustoconical outer surface opposite the inner threaded surface; an annular bushing having the nut seated therein for rotation therewith; and one or more brake shoes positioned around an outside of the annular bushing, the brake shoes having an outer coupling surface in frictional contact with the inner coupling surface of the pulley member; wherein the nut is capable of axial translation relative to the annular bushing and the annular bushing is capable of expanding radially outward in response to the axial translation of the nut in a first direction. a shaft engaging hub including an axis of rotation, an outer threaded surface, and a bore for receiving an accessory input shaft for engagement therewith; a pulley member including a bore that receives the shaft engaging hub, the pulley member including an inner coupling surface and an outer peripheral belt-engaging surface; a nut including an inner threaded surface that is engaged with the outer threaded surface of the shaft engaging hub, the nut having a frustoconical outer surface opposite the inner threaded surface; an annular bushing having the nut seated therein for rotation therewith; and one or more brake shoes positioned around an outside of the annular bushing, the brake shoes having an outer coupling surface in frictional contact with the inner coupling surface of the pulley member; wherein the nut is capable of axial translation relative to the annular bushing and the annular bushing is capable of expanding radially outward in response to the axial translation of the nut in a first direction.
Handling device for holding objects, in particular a gripping device or clamping device, comprising a base portion and a contact portion, the contact portion bearing against the object when the object is held, and comprising a sensor apparatus having a first sensor component and a second sensor component, the two sensor components (28, 30) interacting to determine operating parameters of the handling device, the sensor apparatus being designed to determine a change in the position of the first sensor component relative to the second sensor component, the first sensor component being designed and arranged such that, when an object bears against and is held on the contact portion, a displacement of the object relative to the base portion is connected to a displacement of the first sensor component relative to the base portion, and the second sensor component being arranged in a fixed position relative to the base portion, the sensor apparatus being designed to determine the distance between the first sensor component and the second sensor component, characterized in that the handling device is designed to hold the object by means of negative pressure, comprising an elastically deformable suction body, the contact portion being formed on a region of the suction body that faces the held object. and comprising a sensor apparatus having a first sensor component and a second sensor component, the two sensor components (28, 30) interacting to determine operating parameters of the handling device, the sensor apparatus being designed to determine a change in the position of the first sensor component relative to the second sensor component, the first sensor component being designed and arranged such that, when an object bears against and is held on the contact portion, a displacement of the object relative to the base portion is connected to a displacement of the first sensor component relative to the base portion, and the second sensor component being arranged in a fixed position relative to the base portion, the sensor apparatus being designed to determine the distance between the first sensor component and the second sensor component, characterized in that the handling device is designed to hold the object by means of negative pressure, comprising an elastically deformable suction body, the contact portion being formed on a region of the suction body that faces the held object.
A process for producing potassium formate, whereby formaldehyde, potassium hydroxide, and isobutyraldehyde are reacted in water, at a molar ratio of 1.0:1.0:1.0 to 3.0:2.0:1.0, and at a temperature of 0-100 °C, characterized in that the reaction solution obtained is neutralized to pH 4-6 and evaporated in a first step, whereby two phases are obtained, one organic phase and one aqueous phase, the latter comprising the main part of the potassium formate, that the organic phase is subsequently separated from the aqueous phase, after which a final evaporation of the aqueous phase takes place at a pressure of 0.0-1.0 bar, and a temperature of 160-250 °C, to obtain a melt of potassium formate, to which water is added followed by filtration of the potassium formate solution obtained, resulting in a solution having a content of >99% by weight of potassium formate, calculated on a water free basis.
A system for use in monitoring parameters of an object, the system comprising an illumination unit configured for providing coherent illumination of a predetermined wavelength range and for directing said coherent illumination onto an inspection region of the object, and a collection unit comprising a lens arrangement and a detector array and configured for collecting light returning from the inspection region and for generating one or more image data pieces associated with speckle patterns generated at an intermediate plane between the inspection region and said detector array; wherein: said detector array is configured as a rolling shutter type detector unit and said collection unit comprises at least one light splitting element configured for splitting collected light to thereby form a plurality of image replications corresponding to said speckle patterns on said detector array on different regions of the detector array, readout of said plurality of image replications providing time shift in collection between different replications
A lamp including a heatsink, a lighting element disposed within a seat and a support structure configured to support said heatsink, said heatsink and said support structure being mutually constrained by means of solvable magnetic means, said heatsink being realized with a method comprising the steps of: - obtaining at least one tubular element extending along a main axis and defining a section having a convex shape corresponding to a ring defining a minimum thickness of 5 mm, an internal partition and an external partition, - cutting said tubular element along said main axis in such a way as to make at least one shell defining a section having a convex shape corresponding to a portion of said ring, - drilling one of said partitions (22,21) in such a way as to define said seat configured to house the lighting element in such a way as to realize said heatsink. - obtaining at least one tubular element extending along a main axis and defining a section having a convex shape corresponding to a ring defining a minimum thickness of 5 mm, an internal partition and an external partition, - cutting said tubular element along said main axis in such a way as to make at least one shell defining a section having a convex shape corresponding to a portion of said ring, - drilling one of said partitions (22,21) in such a way as to define said seat configured to house the lighting element in such a way as to realize said heatsink.
Apparatus for making a panel comprising at least one external layer on which structural elements with an oblong development are disposed, distanced from each other at pre-established distances, wherein said apparatus comprises: - a preparation unit provided to divide said structural elements, distancing them from each other; - an assembly unit on which to dispose said external layer during use; - a gripping and delivery unit, mobile between said preparation unit and said assembly unit and comprising a plurality of gripping units each of which is configured to pick up at least one of said structural elements from said preparation unit and to deliver said structural elements to said assembly unit, disposing them on said external layer distanced from each other at said pre-established distances, characterized in that said gripping and delivery unit also comprises positioning members provided to move said gripping units reciprocally nearer/away from each other in order to define said pre-established distances of said structural elements. - a preparation unit provided to divide said structural elements, distancing them from each other; - an assembly unit on which to dispose said external layer during use; - a gripping and delivery unit, mobile between said preparation unit and said assembly unit and comprising a plurality of gripping units each of which is configured to pick up at least one of said structural elements from said preparation unit and to deliver said structural elements to said assembly unit, disposing them on said external layer distanced from each other at said pre-established distances, characterized in that said gripping and delivery unit also comprises positioning members provided to move said gripping units reciprocally nearer/away from each other in order to define said pre-established distances of said structural elements.
Method for operating an access system that comprises an access device, in particular for a refuse container, said method comprising the following steps: a. registering the user using a communication apparatus of a data management system by means of a first communication channel; b. sending a data record to the communication apparatus by means of the data management system via the first communication channel, wherein the data record comprises authentication data and validation data; c. initiating the exchange of data between the communication apparatus and the access device via a second communication channel, wherein at least the authentication data are transferred to the access device, wherein the second communication channel is a wireless connection; d. checking the authentication data for the authorisation of the user using a control means of the access device; wherein the registration is carried out only once and the authentication data authorise access to the access device in a predetermined validity range, wherein, when data are exchanged via the second communication channel, the communication apparatus does not have to be connected to the data management system by means of the first communication channel, characterised in that the communication apparatus automatically queries the authorisation of the user from the data management system within a predetermined period, the authentication data on the communication apparatus being deleted and no longer transferred to the access device if the user does not have authorisation. a. registering the user using a communication apparatus of a data management system by means of a first communication channel; b. sending a data record to the communication apparatus by means of the data management system via the first communication channel, wherein the data record comprises authentication data and validation data; c. initiating the exchange of data between the communication apparatus and the access device via a second communication channel, wherein at least the authentication data are transferred to the access device, wherein the second communication channel is a wireless connection; d. checking the authentication data for the authorisation of the user using a control means of the access device;
A pet chew toy comprising a blend containing a polyamide terpolymer and a diene elastomer, wherein said diene elastomer is crosslinked and said polyamide terpolymer is formed of three different polyamide segments and has a Tm in the range of 120 °C to 250 °C, characterized in that the pet chew toy further comprises two end portions formed from a first material composition; and a central shaft portion between the two end portions, wherein the central shaft portion comprises a second material composition, wherein the first material composition comprises a first blend of said polyamide terpolymer and said diene elastomer and the second material composition comprises a second blend of said polyamide terpolymer and said diene elastomer and wherein the Shore durometer hardness of said second material composition is less than the Shore durometer hardness of said first material composition.
Skip loader apparatus with a demountable and replaceable container, said skip loader apparatus comprising: - a load platform for positioning the container, - a lifting apparatus of the container which comprises two arms hinged at one end with one end of the skip loader apparatus and forming at least one connection point for suspension means of the container at the other end, - hydraulic means connected to the skip loader apparatus and suitable for orienting the two lifting arms of the container for the lifting, deposition and tipping operations of the container, - blocking means for blocking the container relative to the lifting arms, said blocking means being connected to said two lifting arms at a position comprised between the two ends of said lifting arms and being suitable for acting on both the side walls of the container for the tipping operation of the container, said blocking means comprising two elements suitable for engaging with the side walls of the container for the tipping operation of the container, - two recess elements each one connectible to one side wall of the container, said two elements of blocking means being suitable for engaging with said two recess elements, characterized in that said two recess elements are separated from the container and are suitable for engaging with two pins of the container. - a load platform for positioning the container, - a lifting apparatus of the container which comprises two arms hinged at one end with one end of the skip loader apparatus and forming at least one connection point for suspension means of the container at the other end, - hydraulic means connected to the skip loader apparatus and suitable for orienting the two lifting arms of the container for the lifting, deposition and tipping operations of the container, - blocking means for blocking the container relative to the lifting arms, said blocking means being connected to said two lifting arms at a position comprised between the two ends of said lifting arms and being suitable for acting on both the side walls of the container for the tipping operation of the container, said blocking means comprising two elements suitable for engaging with the side walls of the container for the tipping operation of the container, - two recess elements each one connectible to one side wall of the container, said two elements of blocking means being suitable for engaging with said two recess elements, characterized in that said two recess elements are separated from the container and are suitable for engaging with two pins of the container.