mhurhangee/ep-ind-claims huggingface dataset:
A process for creating a C-N bond by reacting a compound carrying a leaving group of general formula with a nucleophilic compound chosen among compound of formula (Ib) wherein: R 0 represents a monocyclic or polycyclic, aromatic or carbocyclic group; Y represents a leaving group chosen among halogen or a group of formula- OSO 2 - R e in which R e is a hydrocarbon or trifluoromethyl group; R 3 and R 4, which may be identical or different, represent a hydrogen atom or a C 1 -C 20 hydrocarbon group, which may be a saturated or unsaturated acyclic linear or branched aliphatic group, and the hydrocarbon chain can optionally carry one or more substituents; a saturated, unsaturated or aromatic, monocyclic or polycyclic carbocyclic group; and at most one of the groups R 3 and R 4 represents hydrogen wherein the reaction takes place in the presence of an effective quantity of a catalytic system comprising a ligand that is chosen among the compound of formula n=0-3 X, X' = O, S wherein R' and R", which may be identical or different, represent a hydrogen atom or a C 1 -C 20 hydrocarbon group chosen among saturated or unsaturated acyclic linear or branched aliphatic group; a saturated, unsaturated or aromatic, monocyclic or polycyclic carbocyclic group; and at most one of the groups R' and R" represents hydrogen; and at least a single metal-based catalyst compound, the metal being iron being said that only a single metal is present. R 0 represents a monocyclic or polycyclic, aromatic or carbocyclic group; Y represents a leaving group chosen among halogen or a group of formula- OSO 2 - R e in which R e is a hydrocarbon or trifluoromethyl group; R 3 and R 4, which may be identical or different, represent a hydrogen atom or a C 1 -C 20 hydrocarbon group, which may be a saturated or unsaturated acyclic linear or branched aliphatic group, and the hydrocarbon chain can optionally carry one or more substituents; a saturated, unsaturated or aromatic, monocyclic or polycyclic carbocyclic group; and at most one of the groups R 3 and R 4 represents hydrogen wherein the reaction takes place in the presence of an effective quantity of a catalytic system comprising a ligand that is chosen among the compound of formula n=0-3 X, X' = O, S wherein R' and R", which may be identical or different, represent a hydrogen atom or a C 1 -C 20 hydrocarbon group chosen among saturated or unsaturated acyclic linear or branched aliphatic group; a saturated, unsaturated or aromatic, monocyclic or polycyclic carbocyclic group; and at most one of the groups R' and R" represents hydrogen; and at least a single metal-based catalyst compound, the metal being iron being said that only a single metal is present.
An optical article comprising a substrate having at least one main face successively coated with: - one or more functional coatings such as a hard coat, - a monolayer sub-layer having a thickness higher than or equal to 250 nm, - a multilayer interferential coating comprising a stack of at least one high refractive index layer having a refractive index higher than 1.55 and at least one low refractive index layer having a refractive index of 1.55 or less, the refractive indexes being expressed for a wavelength of 550 nm, wherein: the optical article has a Bayer value determined in accordance with the ASTM F735-81 standard higher than or equal to 7, characterised in that a) the ratio: R D = thickness of the outermost low refractive index layer s of the int erferential coating thickness of the outermost high refractive index layer s of the int erferential coating is higher than or equal to 2.7 - one or more functional coatings such as a hard coat, - a monolayer sub-layer having a thickness higher than or equal to 250 nm, - a multilayer interferential coating comprising a stack of at least one high refractive index layer having a refractive index higher than 1.55 and at least one low refractive index layer having a refractive index of 1.55 or less, the refractive indexes being expressed for a wavelength of 550 nm, wherein: the optical article has a Bayer value determined in accordance with the ASTM F735-81 standard higher than or equal to 7, characterised in that a) the ratio: R D = thickness of the outermost low refractive index layer s of the int erferential coating thickness of the outermost high refractive index layer s of the int erferential coating is higher than or equal to 2.7 the optical article has a Bayer value determined in accordance with the ASTM F735-81 standard higher than or equal to 7, characterised in that a) the ratio: R D = thickness of the outermost low refractive index layer s of the int erferential coating thickness of the outermost high refractive index layer s of the int erferential coating a) the ratio: R D = thickness of the outermost low refractive index layer s of the int erferential coating thickness of the outermost high refractive index layer s of the int erferential coating is higher than or equal to 2.7
A method for cellular analysis on a cell or a cellular particle employing an elemental analyzer, wherein said cell or cellular particle (i) has been incubated in a hybridization solution with a probe specific for a target nucleic acid, the probe labeled with a unique element tag such that one type of said probe labeled with one type of said tag is distinguishable from any other type of said probe labeled with a different type of said tag by elemental analysis; and (ii) has been separated from unhybridized probe; (iii) has been reacted with affinity reagents specific for surface or/and intracellular molecules, said affinity reagents being labeled with element tags, such that one type of said affinity reagent labeled with one type of said tag is distinguishable from any other type of said tag by elemental analysis; and (iv) has been separated from unbound affinity reagents; wherein the method comprises analyzing the cell or cellular particle by elemental analysis employing the elemental analyzer to identify the probe and quantify the probe bound to the target nucleic acid; and simultaneously analyzing surface and/or intracellular molecules by elemental analysis of the affinity reagents; wherein the cell or the cellular particle is a fixed and permeabilized cell or cellular particle. (i) has been incubated in a hybridization solution with a probe specific for a target nucleic acid, the probe labeled with a unique element tag such that one type of said probe labeled with one type of said tag is distinguishable from any other type of said probe labeled with a different type of said tag by elemental analysis; and (ii) has been separated from unhybridized probe; (iii) has been reacted with affinity reagents specific for surface or/and intracellular molecules, said affinity reagents being labeled with element tags, such that one type of said affinity reagent labeled with one type of said tag is distinguishable from any other type of said tag by elemental analysis; and (iv) has been separated from unbound affinity reagents; wherein the method comprises analyzing the cell or cellular particle by elemental analysis employing the elemental analyzer to identify the probe and quantify the probe bound to the target nucleic acid; and simultaneously analyzing surface and/or intracellular molecules by elemental analysis of the affinity reagents; wherein the cell or the cellular particle is a fixed and permeabilized cell or cellular particle.
Extrusion device comprising an extrusion head for establishing a connection to at least two extruders and at least one tool for shaping a product from at least two extruded materials, the extrusion head having a first pivotable head part and a second pivotable head part, and at least one extension element is disposed in a region of the tool facing the extrusion head, and the extension element has at least one flow path (21, 22, 23, 24) for the extruded material in the region of a first surface and is of a substantially smooth design in the region of its second surface facing away from the first surface, characterised in that the extension element is pivotably connected in a flap-like manner to the first head part via a pivot joint and when the extrusion head is in an open position, the extension element is oriented in a direction towards the second head part of the extrusion head and when the extrusion head is in a closed position, the extension element is disposed between the first head part and the second head part of the extrusion head.
A method of manufacturing a flexible electronic device, the method comprising: arranging an electronic component on a temporary carrier; providing a flexible laminate comprising an adhesive layer; pressing the temporary carrier and the flexible laminate together with the adhesive layer facing the temporary carrier such that the electronic component is pushed into the adhesive layer; and removing the temporary carrier, wherein the flexible laminate further comprises a flexible layer and an electrically conductive layer, the flexible layer being arranged between the electrically conductive layer and the adhesive layer. arranging an electronic component on a temporary carrier; providing a flexible laminate comprising an adhesive layer; pressing the temporary carrier and the flexible laminate together with the adhesive layer facing the temporary carrier such that the electronic component is pushed into the adhesive layer; and removing the temporary carrier, wherein the flexible laminate further comprises a flexible layer and an electrically conductive layer, the flexible layer being arranged between the electrically conductive layer and the adhesive layer.
Composition, notably cosmetic composition, in particular for making up and/or caring for keratin materials, comprising: - at least one aqueous phase containing: (i) at least a first hydrophilic gelling agent chosen from non-starchy polysaccharides; and (ii) at least a second hydrophilic gelling agent chosen from 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers; - at least one oily phase containing: (a) at least a first lipophilic gelling agent chosen from amino acid-based gelling agents; and (b) at least a second lipophilic gelling agent chosen from dextrin esters; and - said composition also comprising at least one UV-screening agent. - at least one aqueous phase containing: (i) at least a first hydrophilic gelling agent chosen from non-starchy polysaccharides; and (ii) at least a second hydrophilic gelling agent chosen from 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers; (i) at least a first hydrophilic gelling agent chosen from non-starchy polysaccharides; and (ii) at least a second hydrophilic gelling agent chosen from 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers; - at least one oily phase containing: (a) at least a first lipophilic gelling agent chosen from amino acid-based gelling agents; and (b) at least a second lipophilic gelling agent chosen from dextrin esters; and (a) at least a first lipophilic gelling agent chosen from amino acid-based gelling agents; and (b) at least a second lipophilic gelling agent chosen from dextrin esters; and - said composition also comprising at least one UV-screening agent.
A method of deriving motion vector predictor or motion vector predictor candidate for encoding a motion vector of a current prediction unit, PU, in a picture, the method comprising: receiving motion vectors associated with at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) of the current PU and one block within a co-located PU of the current PU; determining a motion vector predictor, MVP, or a MVP candidate based on a MVP set, wherein the MVP set comprises motion vector candidates derived from the motion vectors associated with said at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) and said block within the co-located PU, wherein the motion vectors associated with said at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) and said block within the co-located PU are obtained from a previously coded frame or picture; and applying predictive encoding to the current PU based on the MVP or the MVP candidate; characterized in that the co-located PU comprises blocks T 0,0 to T m,n, where (m+1) is the number of rows of the co-located PU and (n+1) is the number of columns of the co-located PU, and m and n are integers ≥ 3, and said block within the co-located PU is the upper-left block of a central point of the co-located PU, T i,j, where i=(m-1)/2 and j=(n-1)/2. receiving motion vectors associated with at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) of the current PU and one block within a co-located PU of the current PU; determining a motion vector predictor, MVP, or a MVP candidate based on a MVP set, wherein the MVP set comprises motion vector candidates derived from the motion vectors associated with said at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) and said block within the co-located PU, wherein the motion vectors associated with said at least one spatially neighboring block (a 0,..., a n, b 0,..., b m, c, d, e) and said block within the co-located PU are obtained from a previously coded frame or picture; and applying predictive encoding to the current PU based on the MVP or the MVP candidate; characterized in that the co-located PU comprises blocks T 0,0 to T m,n, where (m+1) is the number of rows of the co-located PU and (n+1) is the number of columns of the co-located PU, and m and n are integers ≥ 3, and said block within the co-located PU is the upper-left block of a central point of the co-located PU, T i,j, where i=(m-1)/2 and j=(n-1)/2.
A CD19-antibody drug conjugate (CD19-ADC) for use in treating acute lymphoblastic leukemia, wherein the CD19-ADC is a humanized BU12 antibody conjugated to an mcMMAF molecule wherein the humanized BU12 antibody has a light chain variable region of SEQ ID NO:1 and a heavy chain variable region of SEQ ID NO:2, the method comprising the steps of a) administering a loading dose of the CD19-ADC, followed by b) administering a maintenance dose of the CD19-ADC, wherein the maintenance dose of the CD19-ADC is 2.0 mg/kg body weight and is administered every three weeks. a) administering a loading dose of the CD19-ADC, followed by b) administering a maintenance dose of the CD19-ADC, wherein the maintenance dose of the CD19-ADC is 2.0 mg/kg body weight and is administered every three weeks.
Optical component suitable for use as a coupler between input and output waveguides or in a sensor for temperature or in a sensor for mechanical stress, comprising a substrate having a first refractive index in which spatial regions having a second refractive index are formed, wherein the optical component contains at least one optical metamaterial which contains a plurality of individual pixels (21, 22) each comprising a spatial region having the first or the second refractive index, wherein the substrate contains or consists of at least a first polymer having a first refractive index and the spatial regions with the second refractive index are formed by doping or material modification by laser radiation and/or UV radiation or partial removal of the first polymer by masking and etching and filling with a second polymer, wherein the first refractive index is between 1.0 and 1.6 and the second refractive index is between 1.4 and 1.9 and the second refractive index is greater than the first refractive index.
Barrier device for providing clearance to a free inner space, comprising an at least partially hollow edge body which extends in a height direction and which is intended and configured to be received on a surface while bounding said inner space, wherein said edge body comprises an at least partially hollow chamber that is bounded laterally by side walls (41, 42) and on an upper side by a roof, wherein said side walls narrow in said height direction such that, in a first orientation, the edge body is nestable in said at least partially hollow chamber of a corresponding further barrier device up to a first combined height, characterized in that in a second orientation the edge body is stackable with the edge body of said corresponding further barrier device to form a stable stack with a second combined height which is greater than the first combined height, in that the edge body comprises at a base at least one bridge which maintains, when received on said surface, a distance to the surface, in that said at least partially hollow chamber comprises locally, in particular adjacently of a bridge, a lateral widened portion which is bounded by said side walls (41; 42) and said roof, and in that, in the second, stacked orientation, said bridge can drop along at least a part of said distance over the roof of the widened portion of the hollow chamber of said corresponding further barrier device, such that in said second, stacked orientation said bridge is installed on top of a part of said roof.
A process for the manufacture of semiconductor devices comprising the chemical mechanical polishing of a substrate comprising borophosphosilicate glass (BPSG) material and silicon dioxide in the presence of a chemical mechanical polishing composition comprising: ceria particles, at least one type of anionic phosphate or phosphonate as dispersing agent or charge reversal agent, at least one type of surfactant, and an aqueous medium, wherein the selectivity of borophosphosilicate glass (BPSG) to silicon dioxide is 1:1 or less ceria particles, at least one type of anionic phosphate or phosphonate as dispersing agent or charge reversal agent, at least one type of surfactant, and an aqueous medium,
A photoresist composition comprising a resin that comprises one or more polymerized units of the following structure: wherein R 4 represents hydrogen, straight, branched or cyclic monovalent hydrocarbon group of 1 to 6 carbon atoms, and n is an integer of 0 to 7.
A method of carrying out a demand response, DR, event by a control system (130, 202, 264), for shifting energy consumption for operating the HVAC system to time periods outside of the DR event period, the method comprising: identifying, by the system (130, 202, 264), a DR event period for the DR event; accessing a plurality of parameter sets (810, 812 816, 820); generating a candidate setpoint schedule including the DR event period for each of the plurality of parameter sets (810, 812 816, 820); simulating each of the candidate setpoint schedules using a thermodynamic model of how one or more structures respond to one or more heating, ventilation, and air conditioning, HVAC, systems; generating a predicted indoor temperature profile or a predicted HVAC duty cycle schedule for each of the simulated candidate setpoint schedules; evaluating a cost function for each of the predicted indoor temperature profiles or HVAC duty cycle schedules; selecting an optimal one of the predicted indoor temperature profiles or HVAC duty cycle schedules that minimizes the cost function; and controlling the one or more HVAC systems during the DR event period in accordance with the optimal predicted indoor temperature profile or HVAC duty cycle schedule. identifying, by the system (130, 202, 264), a DR event period for the DR event; accessing a plurality of parameter sets (810, 812 816, 820); generating a candidate setpoint schedule including the DR event period for each of the plurality of parameter sets (810, 812 816, 820); simulating each of the candidate setpoint schedules using a thermodynamic model of how one or more structures respond to one or more heating, ventilation, and air conditioning, HVAC, systems; generating a predicted indoor temperature profile or a predicted HVAC duty cycle schedule for each of the simulated candidate setpoint schedules; evaluating a cost function for each of the predicted indoor temperature profiles or HVAC duty cycle schedules; selecting an optimal one of the predicted indoor temperature profiles or HVAC duty cycle schedules that minimizes the cost function; and controlling the one or more HVAC systems during the DR event period in accordance with the optimal predicted indoor temperature profile or HVAC duty cycle schedule.
A spray assembly mountable on a wall, the spray assembly being configured to receive supply water from a source and emit supply water as a directed spray, the spray assembly comprising: a rearward housing mountable adjacent the wall and defining an internal cavity; a waterway assembly housed by the rearward housing and having a waterway housing having an inlet coupleable to the source; a spray face assembly removably coupled to the waterway assembly; characterised by a tool configured to engage the waterway housing through a gap provided between an exterior surface of the spray face assembly and the rearward housing when the spray face assembly is coupled to the waterway assembly while the tool is at least partially positioned in front of the spray face assembly, whereby the waterway assembly can be rotated to effect tightness of a threaded connection between the waterway assembly and the source if the waterway assembly is coupled to the source. a rearward housing mountable adjacent the wall and defining an internal cavity; a waterway assembly housed by the rearward housing and having a waterway housing having an inlet coupleable to the source; a spray face assembly removably coupled to the waterway assembly; characterised by a tool configured to engage the waterway housing through a gap provided between an exterior surface of the spray face assembly and the rearward housing when the spray face assembly is coupled to the waterway assembly while the tool is at least partially positioned in front of the spray face assembly, whereby the waterway assembly can be rotated to effect tightness of a threaded connection between the waterway assembly and the source if the waterway assembly is coupled to the source.
A candle comprising: a container containing a volume of compressed wax beads inserted in an opening of the container; a solid wax topping layer deposited over the top of said volume of compressed wax beads so that said solid wax topping layer provides a continuous barrier between said volume of compressed wax beads and the opening in said container; a wick centrally positioned in said container and of sufficient length to protrude from the bottom of said candle through the top surface of said solid wax topping layer, wherein the solid wax topping layer has a cone-shaped geometry extending into a conical void of said volume of compressed wax beads. a container containing a volume of compressed wax beads inserted in an opening of the container; a solid wax topping layer deposited over the top of said volume of compressed wax beads so that said solid wax topping layer provides a continuous barrier between said volume of compressed wax beads and the opening in said container; a wick centrally positioned in said container and of sufficient length to protrude from the bottom of said candle through the top surface of said solid wax topping layer, wherein the solid wax topping layer has a cone-shaped geometry extending into a conical void of said volume of compressed wax beads.
Massage apparatus comprising a body having drive means (3, 4) and a massage head, assembly means being arranged between the body and the massage head, said massage head comprising an application surface and at least three massaging tips which extend towards the outside of the application surface, wherein the massaging tips are defined on the application surface according to concentric virtual circles of centre C and wherein the massage head comprises a transmission mechanism configured to be driven by the drive means and to bring closer the massaging tips and/or, conversely, to move away the massaging tips, by translating said massaging tips in one direction and/or in the other direction according to the trajectories (T 1, T 2) which meet at the centre C.