A system for use in configuring cardiac therapy comprising: electrode apparatus comprising a plurality of external electrodes to monitor electrical activity from tissue of a patient; and a computing apparatus comprising processing circuitry and operably coupled to the electrode apparatus, the computing apparatus configured to: monitor electrical activity using the plurality of external electrodes during the delivery of cardiac pacing therapy at a plurality of different paced settings, generate paced electrical heterogeneity information based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, determine a first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the paced EHI, generate one or more single-electrode cardiac metrics and vectorcardiographic metrics based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, and determine a second subset of the first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the one or more single-electrode cardiac metrics and vectorcardiographic metrics if the first subset of paced settings comprises more than one paced setting. electrode apparatus comprising a plurality of external electrodes to monitor electrical activity from tissue of a patient; and a computing apparatus comprising processing circuitry and operably coupled to the electrode apparatus, the computing apparatus configured to: monitor electrical activity using the plurality of external electrodes during the delivery of cardiac pacing therapy at a plurality of different paced settings, generate paced electrical heterogeneity information based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, determine a first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the paced EHI, generate one or more single-electrode cardiac metrics and vectorcardiographic metrics based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, and determine a second subset of the first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the one or more single-electrode cardiac metrics and vectorcardiographic metrics if the first subset of paced settings comprises more than one paced setting. monitor electrical activity using the plurality of external electrodes during the delivery of cardiac pacing therapy at a plurality of different paced settings, generate paced electrical heterogeneity information based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, determine a first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the paced EHI, generate one or more single-electrode cardiac metrics and vectorcardiographic metrics based on the monitored electrical activity during delivery of cardiac pacing therapy at the plurality of different paced settings, and determine a second subset of the first subset of the plurality of different paced settings for the cardiac pacing therapy that are acceptable based on the one or more single-electrode cardiac metrics and vectorcardiographic metrics if the first subset of paced settings comprises more than one paced setting.