A compound of Formula or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR 2 orN: Q is: (i) or (ii) 9- to 10-membered bicyclic heteroaryl selected from wherein Ring A is a 5- to 6-membered aryl or heteroaryl fused ring; R 1 is: (i) H, halo, C 1-4 fluoroalkyl, C 1-6 alkoxy, C 1-4 fluoroalkoxy, -S(C 1-4 fluoroalkyl), -O(C 1-4 alkylenyl)O(C 1-3 alkyl), -O(CH 2) 1-4 N( C 1-3 alkyl) 2, -O(C 3-6 alkynyl), or -O(methylpiperidinyl); (ii) phenyl substituted with zero to 2 substituents independently selected from F, Cl, -CF 3, and/or -OCH 3; (iii) C 3-6 cycloalkyl, morpholinyl, thiazolyl, pyridinyl, pyridazinyl, or pyrazinyl; or (iv) -O(CH 2) 1-4 R x wherein R x is imidazolyl, thiazolyl, phenyl, fluorophenyl, chlorophenyl, methoxyphenyl, naphthalenyl, or pyrazinyl; R 2 is H or -NHS 2 (C 1-4 alkyl); and R 3 is: (i) F, Cl, C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 fluoroalkoxy; (ii) C 3-6 cyclopropyl, morpholinyl, pyrazolyl, imidazolyl, or triazolyl; (iii) -O(CH 2) 1-4 R y wherein R y is phenyl, morpholinyl, or pyridazinyl; (iv) pyrrolidinyl substituted with zero to 2 substituents independently selected from -CH 3 and/or -OH; or (v) -NH 2, -NH(C 1-4 alkyl), -NH(C 2-3 fluoroalkyl), or -NH(C 3-6 cycloalkyl); with the provisio that the compound of Formula is not 4-(benzo[b]thiophen-7-yl)isoquinoline. X is O and Y is N; or X is S and Y is CH; Z is CR 2 orN: Q is: (i) or (ii) 9- to 10-membered bicyclic heteroaryl selected from wherein Ring A is a 5- to 6-membered aryl or heteroaryl fused ring; (i) or (ii) 9- to 10-membered bicyclic heteroaryl selected from R 1 is: (i) H, halo, C 1-4 fluoroalkyl, C 1-6 alkoxy, C 1-4 fluoroalkoxy, -S(C 1-4 fluoroalkyl), -O(C 1-4 alkylenyl)O(C 1-3 alkyl), -O(CH 2) 1-4 N( C 1-3 alkyl) 2, -O(C 3-6 alkynyl), or -O(methylpiperidinyl); (ii) phenyl substituted with zero to 2 substituents independently selected from F, Cl, -CF 3, and/or -OCH 3; (iii) C 3-6 cycloalkyl, morpholinyl, thiazolyl, pyridinyl, pyridazinyl, or pyrazinyl; or (iv) -O(CH 2) 1-4 R x wherein R x is imidazolyl, thiazolyl, phenyl, fluorophenyl, chlorophenyl, methoxyphenyl, naphthalenyl, or pyrazinyl; (i) H, halo, C 1-4 fluoroalkyl, C 1-6 alkoxy, C 1-4 fluoroalkoxy, -S(C 1-4 fluoroalkyl), -O(C 1-4 alkylenyl)O(C 1-3 alkyl), -O(CH 2) 1-4 N( C 1-3 alkyl) 2, -O(C 3-6 alkynyl), or -O(methylpiperidinyl); (ii) phenyl substituted with zero to 2 substituents independently selected from F, Cl, -CF 3, and/or -OCH 3; (iii) C 3-6 cycloalkyl, morpholinyl, thiazolyl, pyridinyl, pyridazinyl, or pyrazinyl; or (iv) -O(CH 2) 1-4 R x wherein R x is imidazolyl, thiazolyl, phenyl, fluorophenyl, chlorophenyl, methoxyphenyl, naphthalenyl, or pyrazinyl; R 2 is H or -NHS 2 (C 1-4 alkyl); and R 3 is: (i) F, Cl, C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 fluoroalkoxy; (ii) C 3-6 cyclopropyl, morpholinyl, pyrazolyl, imidazolyl, or triazolyl; (iii) -O(CH 2) 1-4 R y wherein R y is phenyl, morpholinyl, or pyridazinyl; (iv) pyrrolidinyl substituted with zero to 2 substituents independently selected from -CH 3 and/or -OH; or (v) -NH 2, -NH(C 1-4 alkyl), -NH(C 2-3 fluoroalkyl), or -NH(C 3-6 cycloalkyl); with the provisio that the compound of Formula is not 4-(benzo[b]thiophen-7-yl)isoquinoline. (i) F, Cl, C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 fluoroalkoxy; (ii) C 3-6 cyclopropyl, morpholinyl, pyrazolyl, imidazolyl, or triazolyl; (iii) -O(CH 2) 1-4 R y wherein R y is phenyl, morpholinyl, or pyridazinyl; (iv) pyrrolidinyl substituted with zero to 2 substituents independently selected from -CH 3 and/or -OH; or (v) -NH 2, -NH(C 1-4 alkyl), -NH(C 2-3 fluoroalkyl), or -NH(C 3-6 cycloalkyl); with the provisio that the compound of Formula is not 4-(benzo[b]thiophen-7-yl)isoquinoline.