A device for delivering a predetermined amount V sub of at least one substance, within at least one body cavity of a subject, said device comprising: at least one capsule (1, 6, 21, 24, 10, 100) sized and shaped for containing said predetermined amount V sub [ml] of said at least one substance; a delivery end (9, 4A, 28, 42, 1100) for placement in proximity to said at least one body cavity, said delivery end being in fluid communication with said at least one capsule; said delivery end comprises at least one orifice of diameter D [mm]; at least one valve mechanically connectable to said at least one capsule, wherein the valve comprises at least two configurations: (i) an active configuration in which said at least one valve enables delivery of predetermined amount V sub of said at least one substance from said at least one capsule to said at least one body cavity via said delivery end; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined amount V sub of said at least one substance from said at least one capsule to said at least one body cavity; said at least one valve is reconfigurable from said inactive configuration to said active configuration, and vice versa, within a predetermined period of time, dT, in response to activation of said at least one valve; and a fluid tight chamber (2, 4) configured to contain a predetermined volume V gas [ml] of pressurized gas at a predetermined pressure, P gas [barg]; said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, entrains said at least one substance and delivers said at least one substance via said at least one orifice in said delivery end within said at least one body cavity; wherein said device is configured to deliver said predetermined amount V sub of said at least one substance and said predetermined volume V gas of said pressurized gas through said at least one orifice of diameter D [mm] in (a) pressure rate of dP gas /dT; (b) volume rate of dV gas /dT; and (c) volume rate of dV sub /dT; and wherein further (a) the predetermined pressure P gas is in a range of 1 - 10 barg; (b) the predetermined volume V gas is in a range of 1 - 21 ml; (c) the predetermined amount V sub is in at least one range selected from a group consisting of: 0.01-7 ml and 1-1000 mg; and (d) the diameter D is in a range of 0.2 - 6 mm, characterized in that said at least one capsule comprises at least one mixing ball configured to provide a mixing function of said at least one substance during activation. at least one capsule (1, 6, 21, 24, 10, 100) sized and shaped for containing said predetermined amount V sub [ml] of said at least one substance; a delivery end (9, 4A, 28, 42, 1100) for placement in proximity to said at least one body cavity, said delivery end being in fluid communication with said at least one capsule; said delivery end comprises at least one orifice of diameter D [mm]; at least one valve mechanically connectable to said at least one capsule, wherein the valve comprises at least two configurations: (i) an active configuration in which said at least one valve enables delivery of predetermined amount V sub of said at least one substance from said at least one capsule to said at least one body cavity via said delivery end; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined amount V sub of said at least one substance from said at least one capsule to said at least one body cavity; said at least one valve is reconfigurable from said inactive configuration to said active configuration, and vice versa, within a predetermined period of time, dT, in response to activation of said at least one valve; and a fluid tight chamber (2, 4) configured to contain a predetermined volume V gas [ml] of pressurized gas at a predetermined pressure, P gas [barg]; said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, entrains said at least one substance and delivers said at least one substance via said at least one orifice in said delivery end within said at least one body cavity; wherein said device is configured to deliver said predetermined amount V sub of said at least one substance and said predetermined volume V gas of said pressurized gas through said at least one orifice of diameter D [mm] in (a) pressure rate of dP gas /dT; (b) volume rate of dV gas /dT; and (c) volume rate of dV sub /dT; and wherein further (a) the predetermined pressure P gas is in a range of 1 - 10 barg; (b) the predetermined volume V gas is in a range of 1 - 21 ml; (c) the predetermined amount V sub is in at least one range selected from a group consisting of: 0.01-7 ml and 1-1000 mg; and (d) the diameter D is in a range of 0.2 - 6 mm, characterized in that said at least one capsule comprises at least one mixing ball configured to provide a mixing function of said at least one substance during activation. (a) the predetermined pressure P gas is in a range of 1 - 10 barg; (b) the predetermined volume V gas is in a range of 1 - 21 ml; (c) the predetermined amount V sub is in at least one range selected from a group consisting of: 0.01-7 ml and 1-1000 mg; and (d) the diameter D is in a range of 0.2 - 6 mm,