A compound having Formula, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein, each of Q 1 and Q 2 is independently N or CH; X is N or CH; J is -O-, -C(=S)-, -(CH 2) m -O-, -C(=O)-, -C(=O)O-, -S(=O) 1 -, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) 1 N(R 6)-, -CH=CH-, -N(R 6)C(=O)- or -(CH 2) m -; each R 1 is independently -Y-R 5, wherein each Y is independently -O-, -C(=S)-, -(CH 2) m -O-, -C(=O)-, -C(=O)O-, -S(=O) 1 -, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) t N(R 6)-, -CH=CH-, -N(R 6)C(=O)- or -(CH 2) m -; each R 1a is independently H, F, Cl, Br, I, cyano, hydroxy, amino, carboxy, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, alkenyl, alkynyl, nitro, mercapto, hydraxyalkoxy, hydroxyalkyl, aminoalkoxy, alky(-O-C(=O)-, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, aryloxy, heteroaryloxy, haloalkoxy or cycloalkylalkyl; each of R 2 and R 3 is independently H, F, Cl, Br, I, cyano, hydroxy, carboxy, alkyl, haloalkyl, alkoxy, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 4 is independently H, hydroxy, carboxy, amino, F, Cl, Br, I, cyano, nitro, mercapto, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 5 is independently bridged heterobicyclyl, bridged bicyclyl, fused bicyclyl, fused heterobicyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 6 is H; each t is independently 0, 1 or 2; each m is independently 1, 2, 3 or 4; each of n and p is independently 0, 1, 2, 3 or 4; and k is 1, 2, 3 or 4; wherein each of -(CH 2) m -O-, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) t N(R 6)-, -CH=CH-, -N(R 6)C(=O)-, -(CH 2) m -, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, alkyl-O-C(=O)-, aryl, aryloxy, heteroaryloxy, haloalkoxy, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, bridged heterobicyclyl, bridged bicyclyl, fused bicyclyl, fused heterobicyclyl, alkylamino and alkylthio is independently and optionally substituted with one or more substituents independently selected from H, oxo (=O), F, Cl, Br, I, alkyl -O-C(=O)-, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, cyano, nitro, amino, alkylamino, mercapto, alkylthio, aryl, aryloxy, heteroaryl, heteroaryloxy and haloalkoxy. wherein, each of Q 1 and Q 2 is independently N or CH; X is N or CH; J is -O-, -C(=S)-, -(CH 2) m -O-, -C(=O)-, -C(=O)O-, -S(=O) 1 -, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) 1 N(R 6)-, -CH=CH-, -N(R 6)C(=O)- or -(CH 2) m -; each R 1 is independently -Y-R 5, wherein each Y is independently -O-, -C(=S)-, -(CH 2) m -O-, -C(=O)-, -C(=O)O-, -S(=O) 1 -, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) t N(R 6)-, -CH=CH-, -N(R 6)C(=O)- or -(CH 2) m -; each R 1a is independently H, F, Cl, Br, I, cyano, hydroxy, amino, carboxy, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, alkenyl, alkynyl, nitro, mercapto, hydraxyalkoxy, hydroxyalkyl, aminoalkoxy, alky(-O-C(=O)-, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, aryloxy, heteroaryloxy, haloalkoxy or cycloalkylalkyl; each of R 2 and R 3 is independently H, F, Cl, Br, I, cyano, hydroxy, carboxy, alkyl, haloalkyl, alkoxy, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 4 is independently H, hydroxy, carboxy, amino, F, Cl, Br, I, cyano, nitro, mercapto, alkyl, haloalkyl, alkoxy, alkylamino, alkylthio, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 5 is independently bridged heterobicyclyl, bridged bicyclyl, fused bicyclyl, fused heterobicyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl; each R 6 is H; each t is independently 0, 1 or 2; each m is independently 1, 2, 3 or 4; each of n and p is independently 0, 1, 2, 3 or 4; and k is 1, 2, 3 or 4; wherein each of -(CH 2) m -O-, -(CH 2) m -N(R 6)-, -N(R 6)-, -S(=O) t N(R 6)-, -CH=CH-, -N(R 6)C(=O)-, -(CH 2) m -, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, hydroxyalkoxy, hydroxyalkyl, aminoalkoxy, alkyl-O-C(=O)-, aryl, aryloxy, heteroaryloxy, haloalkoxy, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, bridged heterobicyclyl, bridged bicyclyl, fused bicyclyl, fused heterobicyclyl, alkylamino and alkylthio is independently and optionally substituted with one or more substituents independently selected from H, oxo (=O), F, Cl, Br, I, alkyl -O-C(=O)-, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, cyano, nitro, amino, alkylamino, mercapto, alkylthio, aryl, aryloxy, heteroaryl, heteroaryloxy and haloalkoxy.