A system for facilitating resuscitation, comprising: a resuscitation assembly comprising: a first electrode assembly comprising a therapy side and a first motion sensor, and a second electrode assembly comprising a therapy side and a second motion sensor; processing circuitry operatively connected to the resuscitation assembly and configured to: receive and process signals from at least one of the first and second motion sensors to estimate a compression depth during administration of chest compressions; and an output device for providing guidance to a user to administer chest compressions based on the estimated chest compression depth; characterized in that the processing circuitry is configured to: determine whether the first electrode assembly is positioned on a first portion of the patient's anatomy and whether the second electrode assembly is positioned on a second portion of the patient's anatomy in an anterior-posterior orientation or an anterior-anterior orientation, and calculate the chest compression depth by processing signals received from the first motion sensor and from the second motion sensor when the first electrode assembly and the second electrode assembly are positioned in the anterior-posterior orientation, and processing signals received from only one of the second motion sensor and the first motion sensor positioned on a front of the patient when the first electrode assembly and the second electrode assembly are positioned in the anterior-anterior orientation. a resuscitation assembly comprising: a first electrode assembly comprising a therapy side and a first motion sensor, and a second electrode assembly comprising a therapy side and a second motion sensor; a first electrode assembly comprising a therapy side and a first motion sensor, and a second electrode assembly comprising a therapy side and a second motion sensor; processing circuitry operatively connected to the resuscitation assembly and configured to: receive and process signals from at least one of the first and second motion sensors to estimate a compression depth during administration of chest compressions; and an output device for providing guidance to a user to administer chest compressions based on the estimated chest compression depth; characterized in that the processing circuitry is configured to: determine whether the first electrode assembly is positioned on a first portion of the patient's anatomy and whether the second electrode assembly is positioned on a second portion of the patient's anatomy in an anterior-posterior orientation or an anterior-anterior orientation, and calculate the chest compression depth by processing signals received from the first motion sensor and from the second motion sensor when the first electrode assembly and the second electrode assembly are positioned in the anterior-posterior orientation, and processing signals received from only one of the second motion sensor and the first motion sensor positioned on a front of the patient when the first electrode assembly and the second electrode assembly are positioned in the anterior-anterior orientation. determine whether the first electrode assembly is positioned on a first portion of the patient's anatomy and whether the second electrode assembly is positioned on a second portion of the patient's anatomy in an anterior-posterior orientation or an anterior-anterior orientation, and calculate the chest compression depth by processing signals received from the first motion sensor and from the second motion sensor when the first electrode assembly and the second electrode assembly are positioned in the anterior-posterior orientation, and processing signals received from only one of the second motion sensor and the first motion sensor positioned on a front of the patient when the first electrode assembly and the second electrode assembly are positioned in the anterior-anterior orientation. processing signals received from the first motion sensor and from the second motion sensor when the first electrode assembly and the second electrode assembly are positioned in the anterior-posterior orientation, and processing signals received from only one of the second motion sensor and the first motion sensor positioned on a front of the patient when the first electrode assembly and the second electrode assembly are positioned in the anterior-anterior orientation.