An encapsulated valve system (2, 80, 120, 150) for hygienic fluid processes comprising: a first housing portion (4, 84, 122, 152) having a first facing surface (30, 85, 178), the first facing surface (30, 85, 178) comprising a plurality of branch pathways (32, 104, 106, 108, 110, 138, 140, 142, 180) formed as a recess within the first facing surface, wherein the recess is hemicylindrical in shape; a second housing portion (6, 86, 124, 154) having a second facing surface (36, 87, 182), the second facing surface (36, 87, 182) comprising a plurality of branch pathways (38, 104, 106, 108, 110, 138, 140, 142, 184) formed as a recess within the second facing surface, wherein the recess is hemicylindrical in shape; a unitary piece of disposable conduit (8, 88) made from un-reinforced polymer tubing configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface, the unitary piece of disposable conduit having a plurality of branches corresponding to the branch pathways of the first housing portion and the second housing portion and wherein the respective recesses of the first housing portion and the second housing portion concentrically surround the unitary piece of disposable conduit in an exoskeleton; and a plurality of automatically-controlled pinch valve actuators (10, 12, 14, 16, 18, 20, 22, 24, 88, 90, 92, 128, 130, 132, 160, 162, 164, 166, 168, 170, 172, 174) mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators having respective pinching elements configured to directly contact and pinch the disposable conduit at selective branch pathways; one or more fasteners (54, 94, 134, 200) configured to hold the first housing portion against the second housing portion to form the exoskeleton that prevents the formation of aneurysms in the un-reinforced polymer tubing when exposed to high pressure fluid. a first housing portion (4, 84, 122, 152) having a first facing surface (30, 85, 178), the first facing surface (30, 85, 178) comprising a plurality of branch pathways (32, 104, 106, 108, 110, 138, 140, 142, 180) formed as a recess within the first facing surface, wherein the recess is hemicylindrical in shape; a second housing portion (6, 86, 124, 154) having a second facing surface (36, 87, 182), the second facing surface (36, 87, 182) comprising a plurality of branch pathways (38, 104, 106, 108, 110, 138, 140, 142, 184) formed as a recess within the second facing surface, wherein the recess is hemicylindrical in shape; a unitary piece of disposable conduit (8, 88) made from un-reinforced polymer tubing configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface, the unitary piece of disposable conduit having a plurality of branches corresponding to the branch pathways of the first housing portion and the second housing portion and wherein the respective recesses of the first housing portion and the second housing portion concentrically surround the unitary piece of disposable conduit in an exoskeleton; and a plurality of automatically-controlled pinch valve actuators (10, 12, 14, 16, 18, 20, 22, 24, 88, 90, 92, 128, 130, 132, 160, 162, 164, 166, 168, 170, 172, 174) mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators having respective pinching elements configured to directly contact and pinch the disposable conduit at selective branch pathways; one or more fasteners (54, 94, 134, 200) configured to hold the first housing portion against the second housing portion to form the exoskeleton that prevents the formation of aneurysms in the un-reinforced polymer tubing when exposed to high pressure fluid.