mhurhangee/ep-ind-claims huggingface dataset:
An in vitro method for selecting human mesenchymal precursor cells (MPCs) for use in treatment comprising: (i) culturing an obtained population of human MPCs enriched for STRO-1 + or TNAP + MPCs; (ii) determining the amount of TGFβ1 released by the human MPCs into the culture medium; and (iii) selecting for use in treatment the human MPCs that release TGFβ1 into the culture medium in an amount of at least 2800 pg/10 6 cells. (i) culturing an obtained population of human MPCs enriched for STRO-1 + or TNAP + MPCs; (ii) determining the amount of TGFβ1 released by the human MPCs into the culture medium; and (iii) selecting for use in treatment the human MPCs that release TGFβ1 into the culture medium in an amount of at least 2800 pg/10 6 cells.
A method for the preparation of deuterated imidazole diketone compounds, characterized in that it includes the following steps: wherein R 1 and R 2 are independently selected from C 1 -C 4 alkyls; R 3, R 4, and R 5 are selected from hydrogen and deuterium, in which at least one of them is deuterium; using a compound of formula and compounds of formula as starting material, wherein compounds of formula are obtained by a substitution reaction; Compounds of formula are prepared by esterification of the carboxyl group in compounds of formula, wherein R is selected from C 1 -C 6 alkyls; Cyclization of compounds of formula and compound of formula provides compounds of formula; Compounds of formula are deesterified to produce compounds of formula; compounds of formula and compounds of formula (VIII) are reacted, wherein the deuterated imidazole diketone compounds of formula are obtained by a condensation reaction forming an amide bond. wherein R 1 and R 2 are independently selected from C 1 -C 4 alkyls; R 3, R 4, and R 5 are selected from hydrogen and deuterium, in which at least one of them is deuterium; using a compound of formula and compounds of formula as starting material, wherein compounds of formula are obtained by a substitution reaction; Compounds of formula are prepared by esterification of the carboxyl group in compounds of formula, wherein R is selected from C 1 -C 6 alkyls; Cyclization of compounds of formula and compound of formula provides compounds of formula; Compounds of formula are deesterified to produce compounds of formula; compounds of formula and compounds of formula (VIII) are reacted, wherein the deuterated imidazole diketone compounds of formula are obtained by a condensation reaction forming an amide bond. using a compound of formula and compounds of formula as starting material, wherein compounds of formula are obtained by a substitution reaction; Compounds of formula are prepared by esterification of the carboxyl group in compounds of formula, wherein R is selected from C 1 -C 6 alkyls; Cyclization of compounds of formula and compound of formula provides compounds of formula; Compounds of formula are deesterified to produce compounds of formula; compounds of formula and compounds of formula (VIII) are reacted, wherein the deuterated imidazole diketone compounds of formula are obtained by a condensation reaction forming an amide bond.
A gripper device (10, 100, 210, 250) having a base body (12, 212) with at least one jaw (16, 216) movable in the base body (12, 212) along a travel direction (14, 214), in which the base body (12, 212) has a top side (20, 220) above which a fastening portion (18, 218) of the jaw (16, 216) rises, and the gripper device has a gripper finger (26, 54) which can be located detachably on the fastening portion, and the gripper finger (26, 54) has a recess for receiving the fastening portion, which recess is bounded in some portions by at least two faces (32, 34) extending perpendicular to the travel direction, characterized in that a clamping screw that can be located detachably on the fastening portion is provided, and the fastening portion, when the gripper finger (26, 54) is located on it, can be clamped and/or braced in the recess on the face facing toward the free end of the clamping screw against the face facing away from the free end by a free end of the clamping screw.
A terminal apparatus comprising: a reception unit configured to receive from a base station apparatus first information and second information; and a measuring unit configured to perform measurements, wherein the first information includes information on the measurements, the information on the measurements indicates objects on which the measurements shall be performed, the second information is included in the objects on which the measurements shall be performed, the second information includes information on time positions of one or more synchronization signal blocks for the measurements, each of the one or more of synchronization signal blocks comprises a first synchronization signal, a second synchronization signal, and a physical broadcast channel, PBCH, the measurement unit is configured to perform the measurements based on information indicating whether the time positions of the one or more synchronization signal blocks included in an object are the same as or different from time positions in a serving cell, wherein in a case that the time positions of the one or more synchronization signal blocks included in the object are the same as the time positions of the serving cell, the time positions configured for the serving cell are used and measurements are performed on the synchronization signal blocks of a neighbor cell. a reception unit configured to receive from a base station apparatus first information and second information; and a measuring unit configured to perform measurements, wherein the first information includes information on the measurements, the information on the measurements indicates objects on which the measurements shall be performed, the second information is included in the objects on which the measurements shall be performed, the second information includes information on time positions of one or more synchronization signal blocks for the measurements, each of the one or more of synchronization signal blocks comprises a first synchronization signal, a second synchronization signal, and a physical broadcast channel, PBCH, the measurement unit is configured to perform the measurements based on information indicating whether the time positions of the one or more synchronization signal blocks included in an object are the same as or different from time positions in a serving cell, wherein in a case that the time positions of the one or more synchronization signal blocks included in the object are the same as the time positions of the serving cell, the time positions configured for the serving cell are used and measurements are performed on the synchronization signal blocks of a neighbor cell.
Cable tie having a band (201, 202) and having a tensioning device which is integrated in the band and which divides the band into a first and a second region, each of which regions has a toothed portion, wherein the tensioning device is designed to be pivotable and comprises a latching head and two tensioning hooks, characterized in that the latching head comprises two resilient tabs (301a, 301b), one of which is provided with a latching projection.
A planographic printing plate precursor comprising: a support; and an image recording layer provided on the support, wherein the image recording layer contains an infrared absorbing agent, a polymerization initiator, a polymerizable compound containing a hydrogen bonding group, and hard polymer particles formed by grafting of a monomer having at least one group selected from the group consisting of a urethane group, a urea group, an imide group, an amide group, and a sulfonamide group to the surface of the polymer particles by polymerizing a monomer containing these groups in the presence of the polymer constituting the hard polymer particles, a number average primary particle diameter of the hard polymer particle is in a range of 0.01 to 1 μm and wherein the hard polymer particles have a Rockwell hardness, as determined according to ASTM D785, of 30 or greater. a support; and an image recording layer provided on the support, wherein the image recording layer contains an infrared absorbing agent, a polymerization initiator, a polymerizable compound containing a hydrogen bonding group, and hard polymer particles formed by grafting of a monomer having at least one group selected from the group consisting of a urethane group, a urea group, an imide group, an amide group, and a sulfonamide group to the surface of the polymer particles by polymerizing a monomer containing these groups in the presence of the polymer constituting the hard polymer particles, a number average primary particle diameter of the hard polymer particle is in a range of 0.01 to 1 μm and wherein the hard polymer particles have a Rockwell hardness, as determined according to ASTM D785, of 30 or greater.
A method of manufacturing a part in a series of layers based on a three-dimensional model of the part, the three-dimensional model of the part oriented according to an x-y build plane corresponding to an orientation of a layer of the part and a z-axis orthogonal to the x-y build plane that defines an order of each layer of the part between a bottom and a top of the part, the method comprising: determining a build layer thickness of an additive manufacturing apparatus; scaling the build layer thickness based on a scaling factor between the three-dimensional model of the part and the part; identifying a reference feature of the part within the three-dimensional model; identifying a first feature of the part within the three-dimensional model; determining that the first feature is not aligned along the z-axis based on the build layer thickness by determining a difference between a value of a position of a bottom-most point of the first feature along the z-axis and a value of a position of a bottom-most point of the reference feature along the z-axis, scaling the build layer thickness based on the scaling factor, and determining that the difference is not a multiple of the scaled build layer thickness; moving the first feature within the three-dimensional model along the z-axis by a feature offset such that the difference is zero or one or more increments of the build layer thickness; further comprising: manufacturing the part using the additive manufacturing apparatus on a layer by layer basis according to the three-dimensional model, including layers having the build layer thickness. determining a build layer thickness of an additive manufacturing apparatus; scaling the build layer thickness based on a scaling factor between the three-dimensional model of the part and the part; identifying a reference feature of the part within the three-dimensional model; identifying a first feature of the part within the three-dimensional model; determining that the first feature is not aligned along the z-axis based on the build layer thickness by determining a difference between a value of a position of a bottom-most point of the first feature along the z-axis and a value of a position of a bottom-most point of the reference feature along the z-axis, scaling the build layer thickness based on the scaling factor, and determining that the difference is not a multiple of the scaled build layer thickness; moving the first feature within the three-dimensional model along the z-axis by a feature offset such that the difference is zero or one or more increments of the build layer thickness; further comprising: manufacturing the part using the additive manufacturing apparatus on a layer by layer basis according to the three-dimensional model, including layers having the build layer thickness.
Method for determining the temperature on a resistive particle sensor, subjected to an exhaust gas, for soot particles, wherein the resistive particle sensor comprises a heating device, comprising the steps: a) measuring the electrical resistance of a heating element R H, wherein the heating element is a platinum PCT element with a positive temperature coefficient of the electrical resistance, b) determining a model-based temperature T M which is obtained from a temperature model of an engine and of an exhaust train, by means of which model the temperature at the actual particle sensor can be inferred indirectly from the knowledge of an engine rotational speed, engine load, heat capacity and irradiation behaviour of these assemblies on the temperature at the particle sensor itself, c) correlating the resistance R H with the temperature T M determined at the time of the measurement of R H, by means of linear regression, with the result that as the measuring time progresses a point cloud of correlated measured values is produced, d) calculating an equalizing function by means of a quantity of data points acquired in step c) at different temperatures T M, wherein the equalizing function is a linear equation between the temperature T M and the resistance R H which can be determined with improving accuracy in the course of the operation of the particle sensor for soot particles, and e) calculating a sensor temperature T from the values obtained in the equalizing function in step d). a) measuring the electrical resistance of a heating element R H, wherein the heating element is a platinum PCT element with a positive temperature coefficient of the electrical resistance, b) determining a model-based temperature T M which is obtained from a temperature model of an engine and of an exhaust train, by means of which model the temperature at the actual particle sensor can be inferred indirectly from the knowledge of an engine rotational speed, engine load, heat capacity and irradiation behaviour of these assemblies on the temperature at the particle sensor itself, c) correlating the resistance R H with the temperature T M determined at the time of the measurement of R H, by means of linear regression, with the result that as the measuring time progresses a point cloud of correlated measured values is produced, d) calculating an equalizing function by means of a quantity of data points acquired in step c) at different temperatures T M, wherein the equalizing function is a linear equation between the temperature T M and the resistance R H which can be determined with improving accuracy in the course of the operation of the particle sensor for soot particles, and e) calculating a sensor temperature T from the values obtained in the equalizing function in step d).
A water soluble extract composition consisting of components with molecular weights below 41,000 Daltons, obtained from vegetation liquor of a palm oil milling process for use in the treatment and/or prophylaxis of cardio vascular diseases.
Brake for an axially and/or rotationally moved guide rod, comprising a brake housing surrounding the guide rod, a clamping jaw centrally disposed in said brake housing and fixedly connected therewith, said clamping jaw concentrically engaging around the guide rod and exerting radial pressure thereonto when the brake is actuated, and an inner clamping cone axially moved in housing by fluid-actuated and axially movable annular pistons (6, 6.1, 6.2, 6.n), with the axial movement of said cone in a direction radial to guide rod being deflected by inner clamping cone cooperating with clamping jaw cone (3.2), with the piston being limited in size externally by cylindrical brake housing and internally by the cylindrical geometry of guide rod, characterized by brake having therein a plurality of movable and axially slidable annular pistons (6, 6.1, 6.2, 6.n) disposed one behind the other and in parallel with central axis, said annular pistons operatively connected so that the forces add which the pressure fluid causes to act on the individual pistons (6, 6.1, 6.2, 6.n), and by clamping jaw being provided on the inner diameter thereof in the region of the friction couples with a friction material (3.1), with the braking force or the braking torque generated by said friction material being frictionally locked to brake rod.
A process of producing a thermoplastic starch/polymer blend comprising: (a) introducing starch in a dry form into a twin-screw extruder at a first location along the extruder; (b) introducing a plasticizer into the twin-screw extruder at a second location along the extruder downstream of the first location to form a starch paste and then gelatinizing the starch paste in the extruder to form thermoplastic starch; (c) removing water from the thermoplastic starch before introducing dry solid polymer; and (d) introducing dry solid polymer at room temperature into the twin-screw extruder at a third location along the extruder downstream of the second location to form a blend with the thermoplastic starch in the extruder. (a) introducing starch in a dry form into a twin-screw extruder at a first location along the extruder; (b) introducing a plasticizer into the twin-screw extruder at a second location along the extruder downstream of the first location to form a starch paste and then gelatinizing the starch paste in the extruder to form thermoplastic starch; (c) removing water from the thermoplastic starch before introducing dry solid polymer; and (d) introducing dry solid polymer at room temperature into the twin-screw extruder at a third location along the extruder downstream of the second location to form a blend with the thermoplastic starch in the extruder.
A surgical kit for use in a craniectomy procedure, the surgical kit comprising: - a medical device to be implanted in a cranial bone of a patient, the medical device including a support structure and several transducers mounted on the support structure for emitting ultrasound waves of treatment of brain tissue, characterized in that the surgical kit comprises: - a surgical accessory intended to be positioned on the cranial bone of the patient, the surgical accessory including a body dimensioned to approximate the dimensions of the support structure of the medical device, the outer perimeter of the body defining the dimensions of an opening to be made in the cranial bone of the patient in order to receive the medical device, the surgical accessory comprising a plurality of holes in the body, the position of each hole on the body coinciding with the position of the axis of symmetry of a respective transducer on the support structure, each hole defining a mark for the end of a neuronavigation system in order to facilitate the optimal positioning of the opening to be made in the cranial bone. - a medical device to be implanted in a cranial bone of a patient, the medical device including a support structure and several transducers mounted on the support structure for emitting ultrasound waves of treatment of brain tissue, - a surgical accessory intended to be positioned on the cranial bone of the patient, the surgical accessory including a body dimensioned to approximate the dimensions of the support structure of the medical device, the outer perimeter of the body defining the dimensions of an opening to be made in the cranial bone of the patient in order to receive the medical device, the surgical accessory comprising a plurality of holes in the body, the position of each hole on the body coinciding with the position of the axis of symmetry of a respective transducer on the support structure, each hole defining a mark for the end of a neuronavigation system in order to facilitate the optimal positioning of the opening to be made in the cranial bone.
Climbing system for a crane, comprising: a climbing apparatus for inserting a mast section or for removing a mast section from a tower structure of a crane, and a control unit for controlling the climbing apparatus, characterized by a first sensor for monitoring a state of a connection means of the climbing apparatus and/or the tower structure, wherein the first sensor is connected to the control unit. a climbing apparatus for inserting a mast section or for removing a mast section from a tower structure of a crane, and a control unit for controlling the climbing apparatus, characterized by a first sensor for monitoring a state of a connection means of the climbing apparatus and/or the tower structure, wherein the first sensor is connected to the control unit.
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is selected from -C(R 8)= or -N=, wherein R 8 is hydrogen, F or CN; R 1 is selected from the group consisting of: C 1-4 alkyl, cyclopropylmethyl, cyclobutylmethyl and [1-(trifluoromethyl)cyclopropyl]methyl, each of which is optionally substituted with one or more substituents as allowed by valence independently selected from the group consisting of: F and hydroxy; R2 is selected from hydrogen and methyl; when R 2 is hydrogen then R3 is selected from hydrogen, F or Cl; R4 is selected from hydrogen, F or Cl; R 5 is hydrogen; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, F or Cl; except that at least two of R 3, R 4, R 6 and R 7 must be F or Cl unless R 3 is F in which case R 4, R 6 and R 7 may all be hydrogen; and if R 4 is Cl then R 7 cannot be Cl; when R 2 is methyl then R3 is selected from hydrogen, methyl, F, Cl, or Br; R4 is selected from hydrogen, methyl, F or Cl; R5 is selected from hydrogen or F; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, methyl, F or Cl; except that if R 5 is F then at least three of R 3, R 4, R 6 and R 7 must be F; and if R 4 is methyl or Cl then R 7 cannot be methyl or Cl. X is selected from -C(R 8)= or -N=, wherein R 8 is hydrogen, F or CN; R 1 is selected from the group consisting of: C 1-4 alkyl, cyclopropylmethyl, cyclobutylmethyl and [1-(trifluoromethyl)cyclopropyl]methyl, each of which is optionally substituted with one or more substituents as allowed by valence independently selected from the group consisting of: F and hydroxy; R2 is selected from hydrogen and methyl; when R 2 is hydrogen then R3 is selected from hydrogen, F or Cl; R4 is selected from hydrogen, F or Cl; R 5 is hydrogen; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, F or Cl; except that at least two of R 3, R 4, R 6 and R 7 must be F or Cl unless R 3 is F in which case R 4, R 6 and R 7 may all be hydrogen; and if R 4 is Cl then R 7 cannot be Cl; R3 is selected from hydrogen, F or Cl; R4 is selected from hydrogen, F or Cl; R 5 is hydrogen; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, F or Cl; when R 2 is methyl then R3 is selected from hydrogen, methyl, F, Cl, or Br; R4 is selected from hydrogen, methyl, F or Cl; R5 is selected from hydrogen or F; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, methyl, F or Cl; except that if R 5 is F then at least three of R 3, R 4, R 6 and R 7 must be F; and if R 4 is methyl or Cl then R 7 cannot be methyl or Cl. R3 is selected from hydrogen, methyl, F, Cl, or Br; R4 is selected from hydrogen, methyl, F or Cl; R5 is selected from hydrogen or F; R6 is selected from hydrogen or F; and R 7 is selected from hydrogen, methyl, F or Cl;