A catheter system comprising: a processing device comprising a first optical source configured to generate a source beam of exposure radiation, a second optical source configured to generate the laser ablation energy, and a multiplexer; and a catheter comprising: a proximal section, a distal section and a sheath coupled between the proximal section and the distal section; the distal section comprising: a plurality of optical ports configured to: transmit one or more beams of exposure radiation to a sample, receive one more or beams of scattered radiation that have been reflected or scattered from the sample, and transmit laser ablation energy such that at least a portion of the sample is ablated, and a holder configured to maintain the plurality of optical ports in a fixed spatial relationship, wherein the multiplexer is configured to: direct the one or more beams of exposure radiation from the source beam of radiation to the plurality of optical ports, combine the one or more beams of scattered radiation; and direct the laser ablation energy to at least one optical port of the plurality of optical ports, wherein the plurality of optical ports are formed on a substrate having rigid sections and flexible sections. a processing device comprising a first optical source configured to generate a source beam of exposure radiation, a second optical source configured to generate the laser ablation energy, and a multiplexer; and a catheter comprising: a proximal section, a distal section and a sheath coupled between the proximal section and the distal section; the distal section comprising: a plurality of optical ports configured to: transmit one or more beams of exposure radiation to a sample, receive one more or beams of scattered radiation that have been reflected or scattered from the sample, and transmit laser ablation energy such that at least a portion of the sample is ablated, and a holder configured to maintain the plurality of optical ports in a fixed spatial relationship, wherein the multiplexer is configured to: direct the one or more beams of exposure radiation from the source beam of radiation to the plurality of optical ports, combine the one or more beams of scattered radiation; and direct the laser ablation energy to at least one optical port of the plurality of optical ports, wherein the plurality of optical ports are formed on a substrate having rigid sections and flexible sections. a proximal section, a distal section and a sheath coupled between the proximal section and the distal section; the distal section comprising: a plurality of optical ports configured to: transmit one or more beams of exposure radiation to a sample, receive one more or beams of scattered radiation that have been reflected or scattered from the sample, and transmit laser ablation energy such that at least a portion of the sample is ablated, and a holder configured to maintain the plurality of optical ports in a fixed spatial relationship, transmit one or more beams of exposure radiation to a sample, receive one more or beams of scattered radiation that have been reflected or scattered from the sample, and transmit laser ablation energy such that at least a portion of the sample is ablated, and a holder configured to maintain the plurality of optical ports in a fixed spatial relationship, wherein the multiplexer is configured to: direct the one or more beams of exposure radiation from the source beam of radiation to the plurality of optical ports, combine the one or more beams of scattered radiation; and direct the laser ablation energy to at least one optical port of the plurality of optical ports, wherein the plurality of optical ports are formed on a substrate having rigid sections and flexible sections. direct the one or more beams of exposure radiation from the source beam of radiation to the plurality of optical ports, combine the one or more beams of scattered radiation; and direct the laser ablation energy to at least one optical port of the plurality of optical ports, wherein the plurality of optical ports are formed on a substrate having rigid sections and flexible sections.