A single-use endoscope with a handle to which an insertion tube is rigidly connected, the handle having a proximal end, a distal end, a front and a back, and the handle comprising a gripping section separated by a transition section from an operation section of the handle, where the operating section comprises at least one protruding operating member adapted for operation by the thumb of the hand of the operator, the gripping section is adapted for being gripped by three or four fingers of a hand of an operator, the gripping section has an outer gripping section surface surrounding a longitudinal axis of the handle, where said outer gripping section surface defines a periphery with a predetermined curvature of cross-sectional gripping section shapes in a plane perpendicular to the longitudinal axis at points along the longitudinal axis, where said cross-sectional gripping section shapes vary along the longitudinal axis, and where the cross-sectional gripping section shapes are generally mirror symmetrical about a major axis defined by the intersection of the cross-sectional gripping section shape with a longitudinal plane coincident with the longitudinal axis, where the operating section has an outer operating section surface surrounding a longitudinal axis of the handle, said outer operating section surface defines the periphery of cross-sectional operating section shapes in a plane perpendicular to the longitudinal axis at points along the longitudinal axis, where the length of the periphery of a cross-sectional gripping section shape adjacent the transition section is smaller than the length of the periphery of a cross-sectional operating section shape adjacent the transition section, characterized in that the gripping section comprises indentations provided in the outer gripping section surface. the operating section comprises at least one protruding operating member adapted for operation by the thumb of the hand of the operator, the gripping section is adapted for being gripped by three or four fingers of a hand of an operator, the gripping section has an outer gripping section surface surrounding a longitudinal axis of the handle, where said outer gripping section surface defines a periphery with a predetermined curvature of cross-sectional gripping section shapes in a plane perpendicular to the longitudinal axis at points along the longitudinal axis, where said cross-sectional gripping section shapes vary along the longitudinal axis, and where the cross-sectional gripping section shapes are generally mirror symmetrical about a major axis defined by the intersection of the cross-sectional gripping section shape with a longitudinal plane coincident with the longitudinal axis, where the operating section has an outer operating section surface surrounding a longitudinal axis of the handle, said outer operating section surface defines the periphery of cross-sectional operating section shapes in a plane perpendicular to the longitudinal axis at points along the longitudinal axis, where the length of the periphery of a cross-sectional gripping section shape adjacent the transition section is smaller than the length of the periphery of a cross-sectional operating section shape adjacent the transition section, characterized in that the gripping section comprises indentations provided in the outer gripping section surface.