A derivative of allopregnanolone or 1-((3R,5S,10S,13S,17S)-3-hydroxy-10,1 3-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone or epiallopregnanolone or 1-((3S,5S,10S,13S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H cyclopenta[a]phenanthren-17-yl)ethanone according to the following formula: wherein • R 1 is a group selected from the 3-alpha or 3-beta hydroxy groups, 3-alpha or 3-beta O-allyl groups, 3-alpha or 3-beta O-propargyl groups, 3-alpha or 3-beta O-glycol groups, 3-alpha or 3-beta O-PEG groups, 3-alpha or 3-beta O-glycol-allyl groups and 3-alpha or 3-beta O-PEG-allyl groups, • A is a carbon atom substituted by an atom selected from 5-H alpha and 5-H beta and B is a methylene group; or A and B are carbon atoms forming a 5,6-double bond; • C is a carbon atom substituted by an atom selected from 14-H alpha, 14-H beta, 14-alpha OH group and 14-beta OH and D is a methylene group; or C and D are carbon atoms forming a 14,15-double bond; • F is a carbon atom substituted by an atom selected from 17-H alpha and 17-H beta and E is a methylene group or a carbon atom substituted by a group selected from 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or F is a carbon atom substituted by a group selected from 17-alkyl-alpha, 17-alkyl-beta, 17-OR 2 -alpha and 17-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, and E is a methylene group or a carbon atom substituted by group selected from 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or E and F are involved in an epoxy cycle or a cyclopropyl and are selected from 16,17-epoxy-alpha, 16,17-epoxy-beta, 16,17-methylene-alpha and 16,17-methylene-beta; or E and F are carbon atoms forming a 16,17-double bond; • G is a carbonyl, a methylene or a carbon atom substituted by a 12-OR 3 -alpha or 12-OR 3 -beta group wherein R 3 is a H atom or a group selected from the acetyl, alkyl and aryl groups, R 3 may be selected from C 1 -C 6 alkyl, benzyl, p -methoxybenzyl, benzoyl, tigloyl, angeloyl, 2,2,2-trichloroethoxycarbonyl, o-aminobenzoyl, nicotinoyl, 2-methylbutyryl, isovaleryl, cinnamoyl, coumaroyl, o-hydroxybenzoyl and anthraniloyl, excluding (i) the molecule of formula below: and (ii) the molecule of formula below: • R 1 is a group selected from the 3-alpha or 3-beta hydroxy groups, 3-alpha or 3-beta O-allyl groups, 3-alpha or 3-beta O-propargyl groups, 3-alpha or 3-beta O-glycol groups, 3-alpha or 3-beta O-PEG groups, 3-alpha or 3-beta O-glycol-allyl groups and 3-alpha or 3-beta O-PEG-allyl groups, • A is a carbon atom substituted by an atom selected from 5-H alpha and 5-H beta and B is a methylene group; or A and B are carbon atoms forming a 5,6-double bond; • C is a carbon atom substituted by an atom selected from 14-H alpha, 14-H beta, 14-alpha OH group and 14-beta OH and D is a methylene group; or C and D are carbon atoms forming a 14,15-double bond; • F is a carbon atom substituted by an atom selected from 17-H alpha and 17-H beta and E is a methylene group or a carbon atom substituted by a group selected from 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or F is a carbon atom substituted by a group selected from 17-alkyl-alpha, 17-alkyl-beta, 17-OR 2 -alpha and 17-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, and E is a methylene group or a carbon atom substituted by group selected from 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, wherein R 2 is a group selected from allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or E and F are involved in an epoxy cycle or a cyclopropyl and are selected from 16,17-epoxy-alpha, 16,17-epoxy-beta, 16,17-methylene-alpha and 16,17-methylene-beta; or E and F are carbon atoms forming a 16,17-double bond; • G is a carbonyl, a methylene or a carbon atom substituted by a 12-OR 3 -alpha or 12-OR 3 -beta group wherein R 3 is a H atom or a group selected from the acetyl, alkyl and aryl groups, excluding (i) the molecule of formula below: and (ii) the molecule of formula below: