A microdermabrasion device for treating a skin surface, comprising: a handpiece assembly having a distal end and a proximal end, said handpiece assembly comprising at least one delivery conduit and at least one waste conduit; a tip configured to be positioned along the distal end of the handpiece assembly, said tip being configured to contact the skin surface; a flow control device or feature included within the handpiece assembly to regulate the flow of fluids through the at least one delivery conduit; wherein the tip comprises a lip, a first opening in fluid communication with the at least one fluid delivery conduit and a second opening in fluid communication with the at least one waste conduit; at least one abrasive element (574, 576, 578) positioned along a distal end of the tip, said abrasive element (574, 576, 578) being configured to selectively remove skin as the tip is moved relative to a skin surface; and at least one time-release material disposed along at least a portion of the tip, wherein the at least one time-release material is configured to be released to a skin surface when fluids are delivered to the tip via the at least one fluid delivery conduit, wherein the at least one time-release material is configured to become available to the skin surface after a particular time period after initiation of a treatment procedure using the device; wherein the first opening, the second opening and the at least one abrasive element (574, 576, 578) of the tip are positioned within an interior of an outer periphery formed by the lip; wherein the at least one waste conduit is in fluid communication with a vacuum source to selectively remove debris away from the tip; and wherein the at least one delivery conduit is in fluid communication with the at least one waste conduit and the vacuum source when the lip contacts a skin surface. a handpiece assembly having a distal end and a proximal end, said handpiece assembly comprising at least one delivery conduit and at least one waste conduit; a tip configured to be positioned along the distal end of the handpiece assembly, said tip being configured to contact the skin surface; a flow control device or feature included within the handpiece assembly to regulate the flow of fluids through the at least one delivery conduit; wherein the tip comprises a lip, a first opening in fluid communication with the at least one fluid delivery conduit and a second opening in fluid communication with the at least one waste conduit; at least one abrasive element (574, 576, 578) positioned along a distal end of the tip, said abrasive element (574, 576, 578) being configured to selectively remove skin as the tip is moved relative to a skin surface; and at least one time-release material disposed along at least a portion of the tip, wherein the at least one time-release material is configured to be released to a skin surface when fluids are delivered to the tip via the at least one fluid delivery conduit, wherein the at least one time-release material is configured to become available to the skin surface after a particular time period after initiation of a treatment procedure using the device; wherein the first opening, the second opening and the at least one abrasive element (574, 576, 578) of the tip are positioned within an interior of an outer periphery formed by the lip; wherein the at least one waste conduit is in fluid communication with a vacuum source to selectively remove debris away from the tip; and wherein the at least one delivery conduit is in fluid communication with the at least one waste conduit and the vacuum source when the lip contacts a skin surface.