mhurhangee/ep-ind-claims huggingface dataset:
A method of assessing potency of a meningococcal capsular saccharide vaccine comprising: (a) contacting the meningococcal capsular saccharide vaccine with a bactericidal antibody and a control saccharide, wherein the meningococcal capsular saccharide vaccine competes with the control saccharide for binding to the bactericidal antibody; (b) assessing the potency of the meningococcal capsular saccharide vaccine by measuring the binding of the bactericidal antibody to the control saccharide; wherein the meningococcal capsular saccharide vaccine comprises at least two saccharides selected from (i) an N. meningitidis serogroup A capsular saccharide which is a homopolymer of (α1→6)-linked N-acetyl-D-mannosamine-1-phosphate, with partial O-acetylation in the C3 and C4 positions, (ii) an N. meningitidis serogroup C capsular saccharide which is a homopolymer of (α2→9)-linked sialic acid (N-acetyl neuraminic acid ("NeuNAc"), (iii) an N. meningitidis serogroup W135 capsular saccharide which is a polymer of sialic acid-galactose disaccharide units written as: →4)-D-Neu p 5Ac(7/9OAc)-α-(2→6)-D-Gal-α-(1→, and (iv) an N. meningitidis serogroup Y capsular saccharide which is similar to the serogroup W135 saccharide, except that the disaccharide repeating unit includes glucose instead of galactose and the serogroup Y structure is written as: →4)-D-Neu p 5Ac(7/9OAc)-α-(2→6)-D-Glc-α-(1→, and wherein the bactericidal antibody binds to one of the at least two saccharides and to the control saccharide, and wherein the potency is assessed by comparing the inhibition curve with a reference inhibition curve for a reference capsular saccharide of the same serogroup of known potency. (a) contacting the meningococcal capsular saccharide vaccine with a bactericidal antibody and a control saccharide, wherein the meningococcal capsular saccharide vaccine competes with the control saccharide for binding to the bactericidal antibody; (b) assessing the potency of the meningococcal capsular saccharide vaccine by measuring the binding of the bactericidal antibody to the control saccharide;
A display apparatus comprising: a display module configured to display an image; a back cover disposed at a rear surface of the display module, the back cover including a front surface and a rear surface parallelly facing each other to form a uniform thickness of the back cover; a rear depression (S2, Sc) formed in the back cover from the rear surface of the back cover with a first width and a first depth; a front depression (Sa) formed in the back cover from the front surface of the back cover with a third width and a third depth, a through hole (S1, Sb) penetrating the back cover from the front depression (Sa) to the rear depression (S2, Sc) with a second width and a second depth, the second width being smaller than the first width and the third width; a first piezo vibration unit (PZ, PZ2) disposed at a first stepped portion (AH, TH, TH2) formed between the through hole (S1, Sb) and the rear depression (S2, Sc); and a second piezo vibration unit disposed at a second stepped portion formed between the front depression (Sa) and the through hole (S1, Sb). a display module configured to display an image; a back cover disposed at a rear surface of the display module, the back cover including a front surface and a rear surface parallelly facing each other to form a uniform thickness of the back cover; a rear depression (S2, Sc) formed in the back cover from the rear surface of the back cover with a first width and a first depth; a front depression (Sa) formed in the back cover from the front surface of the back cover with a third width and a third depth, a through hole (S1, Sb) penetrating the back cover from the front depression (Sa) to the rear depression (S2, Sc) with a second width and a second depth, the second width being smaller than the first width and the third width; a first piezo vibration unit (PZ, PZ2) disposed at a first stepped portion (AH, TH, TH2) formed between the through hole (S1, Sb) and the rear depression (S2, Sc); and a second piezo vibration unit disposed at a second stepped portion formed between the front depression (Sa) and the through hole (S1, Sb).
A method for transferring power between a power grid and an electric vehicle, the method comprising: maintaining, by an electric vehicle station equipment EVSE separate from the electric vehicle and electrically coupled to the power grid, EVSE attributes, the EVSE attributes defining information relating to the EVSE; characterised by digitally signing, by an authorised party, the EVSE attributes using a digital signature; establishing, by the EVSE, communication with an electric vehicle equipment EVE inside the electric vehicle; transmitting, by the EVSE, the EVSE attributes and the digital signature to the EVE; and in response to the transmitting, receiving, by the EVSE, an instruction from the EVE to energize an electrical connector of the EVSE to electrically couple the EVE to or decouple the EVE from the power grid to supply power between the electric vehicle and the power grid. maintaining, by an electric vehicle station equipment EVSE separate from the electric vehicle and electrically coupled to the power grid, EVSE attributes, the EVSE attributes defining information relating to the EVSE; characterised by digitally signing, by an authorised party, the EVSE attributes using a digital signature; establishing, by the EVSE, communication with an electric vehicle equipment EVE inside the electric vehicle; transmitting, by the EVSE, the EVSE attributes and the digital signature to the EVE; and in response to the transmitting, receiving, by the EVSE, an instruction from the EVE to energize an electrical connector of the EVSE to electrically couple the EVE to or decouple the EVE from the power grid to supply power between the electric vehicle and the power grid.
A method performed by a computing device for generating synthesized pictures that include foreground elements, the method comprising: determining, based on a random selection from a background picture set, a background image for a synthesized picture from the synthesized pictures, wherein the synthesized picture includes the foreground elements, and wherein the background image is used in less than a pre-determined number of the synthesized pictures; dividing sub-regions dynamically for the foreground elements on the background image, each sub-region being used for displaying at least one of the foreground elements, wherein a configuration file includes limitation conditions for dividing the sub-regions on the background image, wherein the configuration file comprises a number of the sub-regions and a position relationship of at least some of the sub-regions, automatically generating a first sub-region layout for positioning the sub-regions on the background image, wherein a specific position of each of the sub-regions is generated by a first execution of a layout algorithm using the configuration file, wherein a second execution of the layout algorithm generates a different sub-region layout for positioning the sub-regions; determining dynamically, within each of the sub-regions, a respective display shape of a foreground element of the sub-region; and drawing, according to the respective display shape, each corresponding foreground element within each respective display shape within each respective sub-region. determining, based on a random selection from a background picture set, a background image for a synthesized picture from the synthesized pictures, wherein the synthesized picture includes the foreground elements, and wherein the background image is used in less than a pre-determined number of the synthesized pictures; dividing sub-regions dynamically for the foreground elements on the background image, each sub-region being used for displaying at least one of the foreground elements, wherein a configuration file includes limitation conditions for dividing the sub-regions on the background image, wherein the configuration file comprises a number of the sub-regions and a position relationship of at least some of the sub-regions, automatically generating a first sub-region layout for positioning the sub-regions on the background image, wherein a specific position of each of the sub-regions is generated by a first execution of a layout algorithm using the configuration file, wherein a second execution of the layout algorithm generates a different sub-region layout for positioning the sub-regions; determining dynamically, within each of the sub-regions, a respective display shape of a foreground element of the sub-region; and drawing, according to the respective display shape, each corresponding foreground element within each respective display shape within each respective sub-region.
A double balanced mixer (300A, 300B, 300D) for mixing an input signal with a local oscillator signal, the mixer comprising: at least four diodes (302A, 302B, 302C, 302D, 372, 374, 376, 378) arranged in a ring and configured to switch based at least partly on the local oscillator signal; and capacitors (304A, 304B, 304C, 304D), each of which is arranged in parallel with a respective diode of the diodes, wherein for each capacitor a first terminal of the capacitor is connected to an anode of the respective diode and a second terminal of the capacitor is connected to a cathode of the respective diode; wherein the mixer is configured to mix the input signal with the local oscillator signal to thereby frequency shift the input signal. at least four diodes (302A, 302B, 302C, 302D, 372, 374, 376, 378) arranged in a ring and configured to switch based at least partly on the local oscillator signal; and capacitors (304A, 304B, 304C, 304D), each of which is arranged in parallel with a respective diode of the diodes, wherein for each capacitor a first terminal of the capacitor is connected to an anode of the respective diode and a second terminal of the capacitor is connected to a cathode of the respective diode; wherein the mixer is configured to mix the input signal with the local oscillator signal to thereby frequency shift the input signal.
A method for customizing a shape of a fan assembly housed within an enclosure, the method comprising: characterizing an efficiency of an air transport through an air inlet opening of the fan assembly positioned within the enclosure, the fan assembly comprising a combination of a fan assembly housing and cover, and a plurality of blades coupled to an impeller, wherein the combination of the fan assembly housing and the cover includes a wall proximate the air inlet; modifying the shape of the fan assembly in accordance with the characterization by enlarging a pinch point area between the wall and the enclosure, wherein modifying the shape includes contouring the wall proximate the air inlet opening so as to increase the efficiency of the air transport through the air inlet; the method being characterised by: reducing the height of at least one of the plurality of blades to conform to the contoured shape of the combination of the fan assembly housing and cover. characterizing an efficiency of an air transport through an air inlet opening of the fan assembly positioned within the enclosure, the fan assembly comprising a combination of a fan assembly housing and cover, and a plurality of blades coupled to an impeller, wherein the combination of the fan assembly housing and the cover includes a wall proximate the air inlet; modifying the shape of the fan assembly in accordance with the characterization by enlarging a pinch point area between the wall and the enclosure, wherein modifying the shape includes contouring the wall proximate the air inlet opening so as to increase the efficiency of the air transport through the air inlet; the method being characterised by: reducing the height of at least one of the plurality of blades to conform to the contoured shape of the combination of the fan assembly housing and cover.
Cooling system for a vehicle having a gearbox cooling circuit which conducts away the thermal energy generated in the gearbox to a cooling water circuit of an internal combustion engine via a heat exchanger, characterized in that the gearbox cooling circuit comprises a bypass line for bypassing the heat exchanger and a control element, wherein the division of the volume flow by the bypass line and the heat exchanger can be controlled by means of the control element, and in that the control element can be actuated as a function of the temperature in the cooling water circuit.
A fibrous construct comprising: a) an ester substrate; b) a first web comprising a plurality of first water soluble fibers and a perhydrolase, wherein the perhydrolase is encapsulated in the first water soluble fibers and is present in an amount from 0.1 to 40 wt% based on the total weight of the first web; c) a second web comprising a plurality of second water soluble fibers and an oxidizing agent, wherein the oxidizing agent is encapsulated in the second water soluble fibers; and wherein the first water soluble fibers and the second water soluble fibers are solution spun water soluble fibers. a) an ester substrate; b) a first web comprising a plurality of first water soluble fibers and a perhydrolase, wherein the perhydrolase is encapsulated in the first water soluble fibers and is present in an amount from 0.1 to 40 wt% based on the total weight of the first web; c) a second web comprising a plurality of second water soluble fibers and an oxidizing agent, wherein the oxidizing agent is encapsulated in the second water soluble fibers; and
Polypeptide comprising a first and a second amino acid sequence, wherein the first amino acid sequence is an endolysin, and wherein the second amino acid sequence is an antimicrobial peptide, cationic peptide, hydrophobic peptide, amphiphatic peptide or sushi peptide, and wherein the polypeptide comprises at least one sequence selected from the following group of sequences: i) an amino acid sequence according to SEQ ID NO:1; ii) a derivative of SEQ ID NO:1 exhibiting at least 80 % sequence identity with SEQ ID NO:1, with the proviso that the polypeptide may not comprise the sequence of SEQ ID NO:5, if the polypeptide comprises ii), but none of: a) an amino acid sequence according to SEQ ID NO:3; b) a derivative of SEQ ID NO:3 exhibiting at least 77 % sequence identity with SEQ ID NO:3; c) an amino acid sequence according to SEQ ID NO:4; with the proviso that the polypeptide may in this case not comprise the sequence of SEQ ID NO:6 in parallel; and d) a derivative of SEQ ID NO:4 exhibiting at least 80 % sequence identity with SEQ ID NO:4, and wherein the polypeptide degrades the peptidoglycan of Salmonella bacteria. i) an amino acid sequence according to SEQ ID NO:1; ii) a derivative of SEQ ID NO:1 exhibiting at least 80 % sequence identity with SEQ ID NO:1, with the proviso that the polypeptide may not comprise the sequence of SEQ ID NO:5, if the polypeptide comprises ii), but none of: a) an amino acid sequence according to SEQ ID NO:3; b) a derivative of SEQ ID NO:3 exhibiting at least 77 % sequence identity with SEQ ID NO:3; c) an amino acid sequence according to SEQ ID NO:4; with the proviso that the polypeptide may in this case not comprise the sequence of SEQ ID NO:6 in parallel; and d) a derivative of SEQ ID NO:4 exhibiting at least 80 % sequence identity with SEQ ID NO:4, and wherein the polypeptide degrades the peptidoglycan of Salmonella bacteria. a) an amino acid sequence according to SEQ ID NO:3; b) a derivative of SEQ ID NO:3 exhibiting at least 77 % sequence identity with SEQ ID NO:3; c) an amino acid sequence according to SEQ ID NO:4; with the proviso that the polypeptide may in this case not comprise the sequence of SEQ ID NO:6 in parallel; and d) a derivative of SEQ ID NO:4 exhibiting at least 80 % sequence identity with SEQ ID NO:4, and wherein the polypeptide degrades the peptidoglycan of Salmonella bacteria.
Process for the production of a polymer comprising the steps of: a) polymerisation of an emulsion or suspension comprising a reaction mixture to obtain a polymeric latex; and b) coagulating the polymeric latex by exposing the polymeric latex to one or more coagulant, and isolating the coagulated product to obtain a polymer; wherein the polymeric latex obtained under a) is stored prior to coagulation step b) for at most such a time that the polymeric latex contains ≤ 500 CFU/ml of pigment-producing organisms as determined in accordance with ASTM D 5465-93 when subjecting the polymeric latex to coagulation step b); wherein the latex is subjected to the storage for a period of ≤ 20h. a) polymerisation of an emulsion or suspension comprising a reaction mixture to obtain a polymeric latex; and b) coagulating the polymeric latex by exposing the polymeric latex to one or more coagulant, and isolating the coagulated product to obtain a polymer;
A method for updating a first secret data in a credential container including a subscriber identity module, said first secret data being used by the credential container to authenticate to a communication network, said credential container comprising a set of secret parameters customized for a network operator and being configured to execute a symmetric mutual authentication algorithm using said first secret data and said set for performing a symmetric mutual authentication with a remote server, wherein the network operator manages a subscription installed in the credential container, and wherein the symmetric mutual authentication is used to authenticate the credential container when the credential container requests to access the communication network, characterized in that the credential container receives from the remote server a second secret data enciphered by using a second algorithm different from said symmetric mutual authentication algorithm and a subset of said secret parameters and in that the credential container deciphers the enciphered second secret data by using both the subset and a third algorithm and replaces the first secret data with the second secret data, wherein the second secret data is then used by the credential container to authenticate to the communication network.
A compound of formula I, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof: Wherein: V is N; W is N or O; R 1 is selected from the following groups: X 1 is a bond, CO, or -(CH 2) n -; Y is -(CH 2) n -, -(CR 2 R 3)-, C 6-14 aryl or C 1-10 heteroaryl, optionally R 2 and R 3 together with the carbon atom to which they are attached, form a C 3 -C 10 carbocyclic ring or a 3- to 10-membered heterocyclic ring, wherein each of said -(CH 2) n -, -(CR 2 R 3)-, C 6-14 aryl, C 1-10 heteroaryl, C 3 -C 10 carbocyclic ring and 3- to 10-membered heterocyclic ring is independently and optionally substituted with one or more substituents chosen from C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, and C 1-6 haloalkyl; Z is a bond, NR 2, -(CH 2) n - or -(CR 2 R 3)-, wherein each of said NR 2, -(CH 2) n - and -(CR 2 R 3)- is independently and optionally substituted with one or more substituents chosen from F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, C 1-6 alkyl, and C 1-6 haloalkyl; n is 0, 1, 2, 3,4 or 5; R 2 and R 3 are independently selected from -H, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-14 aryl or C 1-10 heteroaryl, wherein each of said C 1-6 alkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-14 aryl and C 1-10 heteroaryl is optionally and independently substituted with one or more substituents chosen from F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, and -CO 2 H. V is N; W is N or O; R 1 is selected from the following groups: X 1 is a bond, CO, or -(CH 2) n -; Y is -(CH 2) n -, -(CR 2 R 3)-, C 6-14 aryl or C 1-10 heteroaryl, optionally R 2 and R 3 together with the carbon atom to which they are attached, form a C 3 -C 10 carbocyclic ring or a 3- to 10-membered heterocyclic ring, wherein each of said -(CH 2) n -, -(CR 2 R 3)-, C 6-14 aryl, C 1-10 heteroaryl, C 3 -C 10 carbocyclic ring and 3- to 10-membered heterocyclic ring is independently and optionally substituted with one or more substituents chosen from C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, and C 1-6 haloalkyl; Z is a bond, NR 2, -(CH 2) n - or -(CR 2 R 3)-, wherein each of said NR 2, -(CH 2) n - and -(CR 2 R 3)- is independently and optionally substituted with one or more substituents chosen from F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, C 1-6 alkyl, and C 1-6 haloalkyl; n is 0, 1, 2, 3,4 or 5; R 2 and R 3 are independently selected from -H, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-14 aryl or C 1-10 heteroaryl, wherein each of said C 1-6 alkyl, C 3-7 cycloalkyl, C 2-7 heterocycloalkyl, C 6-14 aryl and C 1-10 heteroaryl is optionally and independently substituted with one or more substituents chosen from F, Cl, Br, I, -NO 2, -CN, -N 3, -NH 2, -OH, and -CO 2 H.
A spinal implant system including a bone anchoring device, a spinal implant, locking means and retention means (32, 25), the bone anchoring device laid out so as to be inserted through a passage crossing through at least one portion of the implant, from an outer surface to a vertebral contact surface, the bone anchoring device including a body comprising at least one stiff plate and elongated along a longitudinal axis extending between an anterior end and a posterior end, the plate being configured so that its anterior end penetrates in at least one vertebral surface while its posterior end remains in the passage of the implant, while retaining said implant against said vertebral surface, the body including at least one abutment adapted to receive at least one locking means to lock said anchoring device relative to the implant, said at least one abutment being oriented not parallel to the longitudinal axis and complementary to at least one abutment of said at least one locking means, said locking means, being provided with at least one flexible portion allowing said abutment of the locking means to be pushed back for inserting the anchoring device into the passage, on the one hand, and mutual engagement of both abutments (14, 31) when they are found facing each other, by the elastic return of the flexible portion, on the other hand, said locking means retained in the implant by retention means (32, 25), the retention means formed by a recess in the locking means and a pin inserted through the spinal implant in a direction perpendicular to an antero-posterior axis in order to cooperate with the recess, the retention means (32,25) preventing the movement of the locking means in the direction of the antero-posterior axis, the antero-posterior axis being the direction of insertion and/or withdrawal of the anchoring device.