A flow control clamp 30 comprising: a flexible body comprising a central portion 35 and first and second legs 36, 38 extending from said central portion 35, said legs disposed relative to each other in a general facing relationship, leg 38 including first and second lateral arms 104 extending from respective sides thereof; said body including a pair of apertures 40, 44 for receiving flexible tubing therethrough wherein one of said apertures 40, 44 is disposed in said central portion 35 and the other of said apertures 40, 44 is disposed in at least one of said legs 36, 38; wherein said legs 36, 38 are movable from a first open spaced apart position to a second closed irreversibly locked position; at least one tube contacting member 48. 50 carried by one of said legs 36, 38 for compressing a tube 43 when said legs 36, 38 are in the closed position; first and second locking mechanisms comprising interengaging locking structures associated with said legs 36, 38, wherein said interengaging locking structures are irreversibly engaged when said legs 36, 38 are in the closed position, said interengaging locking structures of said first locking mechanism comprising first and second interengaging arms (62, 66), and each interengaging arm (62, 66) comprising an engaging member to irreversibly lock the first locking mechanism when in the closed position; said interengaging locking structures of said second locking mechanism comprises a first engaging member 100 on said arms 104 associated with leg 38 and a second engaging member 102 associated with leg 36; wherein said first locking mechanism is positioned farther from said central portion than said second locking mechanism. a flexible body comprising a central portion 35 and first and second legs 36, 38 extending from said central portion 35, said legs disposed relative to each other in a general facing relationship, leg 38 including first and second lateral arms 104 extending from respective sides thereof; said body including a pair of apertures 40, 44 for receiving flexible tubing therethrough wherein one of said apertures 40, 44 is disposed in said central portion 35 and the other of said apertures 40, 44 is disposed in at least one of said legs 36, 38; wherein said legs 36, 38 are movable from a first open spaced apart position to a second closed irreversibly locked position; at least one tube contacting member 48. 50 carried by one of said legs 36, 38 for compressing a tube 43 when said legs 36, 38 are in the closed position; first and second locking mechanisms comprising interengaging locking structures associated with said legs 36, 38, wherein said interengaging locking structures are irreversibly engaged when said legs 36, 38 are in the closed position, said interengaging locking structures of said first locking mechanism comprising first and second interengaging arms (62, 66), and each interengaging arm (62, 66) comprising an engaging member to irreversibly lock the first locking mechanism when in the closed position; said interengaging locking structures of said second locking mechanism comprises a first engaging member 100 on said arms 104 associated with leg 38 and a second engaging member 102 associated with leg 36; wherein said first locking mechanism is positioned farther from said central portion than said second locking mechanism.