mhurhangee/ep-ind-claims huggingface dataset:
A method for producing an antibody-drug conjugate comprising reacting a compound represented by the following formula: (maleimid-N-yl)-(CH 2)n 3 -C(=O)-L 2 -L P -NH-(CH 2)n 1 -L a -(CH 2)n 2 -C(=O)-(NH-DX) with an anti-HER2 antibody or a reactive derivative thereof and conjugating a drug-linker moiety to the antibody by a method for forming a thioether bond at a disulfide bond site present in the hinge part of the antibody, wherein n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents the tetrapeptide residue -GGFG- wherein G represents glycine and F represents phenylalanine, L a represents -O- or a single bond, and (maleimid-N-yl)- is a group represented by the following formula: wherein the nitrogen atom is the connecting position, and -(NH-DX) is a group represented by the following formula: wherein the nitrogen atom of the amino group at position 1 is the connecting position. n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents the tetrapeptide residue -GGFG- wherein G represents glycine and F represents phenylalanine, L a represents -O- or a single bond, and (maleimid-N-yl)- is a group represented by the following formula: wherein the nitrogen atom is the connecting position, and -(NH-DX) is a group represented by the following formula:
A commercial vehicle structure having a sliding cover which is guided along longitudinal roof supports and has at least one end carriage with a springloaded locking bolt, the locking bolt interacting with a closure projection, which is fastened to a longitudinal roof support and has at least two oblique guide faces for the locking bolt, in order to lock the end carriage when the sliding cover is in an open position and/or in a closed position, characterised in that the closure projection forms a V-shaped peak which points towards the vehicle longitudinal axis and is formed by the oblique guide faces, wherein the oblique guide faces join at the peak.
An automatic swimming pool cleaner comprising: a. a body having (i) a water inlet and (ii) a rear area; and b. a debris canister (i) having a shape, (ii) being connected to the body at the rear area, and (iii) having at least a portion external to the body configured so that water having entered the body through the water inlet returns to a swimming pool therethrough when the automatic swimming pool cleaner is in use, characterized in that the debris canister comprises mesh panels and a rigid support frame therefor, at least one of the mesh panels being external to the body and the support frame maintaining the shape of the debris canister regardless of whether water is flowing therethrough. a. a body having (i) a water inlet and (ii) a rear area; and b. a debris canister (i) having a shape, (ii) being connected to the body at the rear area, and (iii) having at least a portion external to the body configured so that water having entered the body through the water inlet returns to a swimming pool therethrough when the automatic swimming pool cleaner is in use,
A composition comprising: an activated pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities; and n represents an integer greater than 1; wherein the activated pre-polymer is an acrylated pre-polymer or a vinylated pre-polymer, and wherein the composition comprises an anhydride compound. an activated pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities; and n represents an integer greater than 1; wherein the activated pre-polymer is an acrylated pre-polymer or a vinylated pre-polymer, and wherein the composition comprises an anhydride compound.
An unmanned underwater vehicle (700, 800) comprising a charge deployment system for ordnance neutralisation, characterised in that the charge deployment system comprises: at least one deployment unit (102, 104, 106), the or each unit comprising: a housing for stowing a charge in a stowed position; mounting means for mounting a charge within the deployment unit (102, 104, 106); moving means for controllably moving a charge and said mounting means from the stowed position to a deployment position; and means for controllably releasing a charge from said mounting means; and, a controller for controlling said or each of said moving means. at least one deployment unit (102, 104, 106), the or each unit comprising: a housing for stowing a charge in a stowed position; mounting means for mounting a charge within the deployment unit (102, 104, 106); moving means for controllably moving a charge and said mounting means from the stowed position to a deployment position; and means for controllably releasing a charge from said mounting means; and, a housing for stowing a charge in a stowed position; mounting means for mounting a charge within the deployment unit (102, 104, 106); moving means for controllably moving a charge and said mounting means from the stowed position to a deployment position; and means for controllably releasing a charge from said mounting means; and, a controller for controlling said or each of said moving means.
A method performed by a target gNB configured to operate in a wireless communication system, the method comprising: receiving, from a source gNB, a handover request message including i) a quality of service, QoS, flow-to-data radio bearer, DRB, mapping rule of the source gNB which is used for mapping a DRB to one or more QoS flows at the source gNB, and ii) other parameters; deciding to use the QoS flow-to-DRB mapping rule of the source gNB at the target gNB; preparing for a L1/L2 handover and transmitting, to the source gNB, a handover request acknowledge message in response to the handover request message, wherein the handover request acknowledge message includes information informing that the QoS flow-to-DRB mapping rule of the source gNB is used at the target gNB; and receiving a data packet, which is forwarded from the source gNB to the target gNB based on the information included in the handover request acknowledge message. receiving, from a source gNB, a handover request message including i) a quality of service, QoS, flow-to-data radio bearer, DRB, mapping rule of the source gNB which is used for mapping a DRB to one or more QoS flows at the source gNB, and ii) other parameters; deciding to use the QoS flow-to-DRB mapping rule of the source gNB at the target gNB; preparing for a L1/L2 handover and transmitting, to the source gNB, a handover request acknowledge message in response to the handover request message, wherein the handover request acknowledge message includes information informing that the QoS flow-to-DRB mapping rule of the source gNB is used at the target gNB; and receiving a data packet, which is forwarded from the source gNB to the target gNB based on the information included in the handover request acknowledge message.
An ice rink inlay, comprising an illuminants arrangement, wherein the illuminants arrangement comprises a multitude of LED-based light sources which are encased in a water-tight manner by way of one or more encasings, wherein the light sources are, at least in a group-wise manner, operationally interconnected by way of electrical connection leads, wherein the connection leads comprise voltage supply leads, characterized in that the ice rink inlay comprises a layer body for forming a cover layer of an ice rink.
Sports footwear comprising: - an upper with a toe portion; - a sole fixed to said upper; - a protection element mounted on a side surface of said toe portion; said protection element being fixed permanently to the side surface and having an outer surface provided with first coupling means (33, 36) for coupling a covering component on the protection element; the covering component having an inner surface provided with first coupling means suitable for cooperating with the first coupling means (33, 36) of the protection element; the first coupling means (33, 36) of the protection element defining a seat suitable for receiving a fastening element for allowing fastening of the covering component onto the protection element; said footwear being characterized in that said seat has a direction of insertion which is substantially parallel to the side surface of the toe portion. - an upper with a toe portion; - a sole fixed to said upper; - a protection element mounted on a side surface of said toe portion; said protection element being fixed permanently to the side surface and having an outer surface provided with first coupling means (33, 36) for coupling a covering component on the protection element; the covering component having an inner surface provided with first coupling means suitable for cooperating with the first coupling means (33, 36) of the protection element; the first coupling means (33, 36) of the protection element defining a seat suitable for receiving a fastening element for allowing fastening of the covering component onto the protection element;
A method for manufacturing a microelectronic device comprising a plurality of resistive memories (100, 100A, 100B, 100C, 200, 200A, 200B, 200C) a first part of these resistive memories (100, 100A, 100B, 100C, 200, 200A, 200B, 200C)being configured to form an unclonable physical function, better known as the acronym PUF, the resistive memories (200, 200A, 200B, 200C) of said first part of resistive memories being said PUF memories, a second part of resistive memories being to provide a memory function to the microelectronic device, the resistive memories (100, 100A, 100B, 100C) of the second part being called storage memories, the manufacturing method comprising the following successive steps of: - providing a support comprising a plurality of first metal electrodes, - for each first electrode (110, 210), forming a dielectric layer portion comprising a first contact surface facing the corresponding first electrode (110, 210) and a second surface opposite to the first contact surface, the dielectric layer portions for forming the PUF memories having, on at least one of the first contact surface and the second surface, a surface roughness greater than that of the same surface of the dielectric layer portions for forming the storage memories, - for each dielectric layer portion (130, 230), forming a second electrode (120, 220) facing the second surface, said second surface then being a second contact surface facing the second electrode (120, 220) and the dielectric layer portion (130, 230) being interposed between the first and second electrodes (120, 230), the resistive memories (100, 100A, 100B, 100C, 200, 200A, 200B, 200C) being thus formed. - providing a support comprising a plurality of first metal electrodes, - for each first electrode (110, 210), forming a dielectric layer portion comprising a first contact surface facing the corresponding first electrode (110, 210) and a second surface opposite to the first contact surface, the dielectric layer portions for forming the PUF memories having, on at least one of the first contact surface and the second surface, a surface roughness greater than that of the same surface of the dielectric layer portions for forming the storage memories, - for each dielectric layer portion (130, 230), forming a second electrode (120, 220) facing the second surface, said second surface then being a second contact surface facing the second electrode (120, 220) and the dielectric layer portion (130, 230) being interposed between the first and second electrodes (120, 230), the resistive memories (100, 100A, 100B, 100C, 200, 200A, 200B, 200C) being thus formed.
A remote control unit for remotely operating an air conditioning apparatus, comprising: a display unit for displaying a menu and a cursor for indicating an arbitrary item inside the menu; cursor-moving means for moving the cursor; confirmation means for deciding that an item indicated by the cursor is to be executed; and a controller for controlling object including the display unit to be controlled in response to the cursor-moving means or the confirmation means; wherein upon receiving a predetermined input, the controller positions an item corresponding to the predetermined input at the top of the menu, characterized in that the controller positions at the top of the menu a fault response item showing the locations of a plurality of relevant information needed by the user when the predetermined input is either a fault notification signal input notifying of a fault from the air conditioning apparatus or a filter maintenance request signal input requesting that the filter of the air conditioning apparatus be cleaned. a display unit for displaying a menu and a cursor for indicating an arbitrary item inside the menu; cursor-moving means for moving the cursor; confirmation means for deciding that an item indicated by the cursor is to be executed; and a controller for controlling object including the display unit to be controlled in response to the cursor-moving means or the confirmation means; wherein upon receiving a predetermined input, the controller positions an item corresponding to the predetermined input at the top of the menu, characterized in that the controller positions at the top of the menu a fault response item showing the locations of a plurality of relevant information needed by the user when the predetermined input is either a fault notification signal input notifying of a fault from the air conditioning apparatus or a filter maintenance request signal input requesting that the filter of the air conditioning apparatus be cleaned.
An abnormality diagnosis system of an air-fuel ratio sensor for use with an exhaust purification catalyst provided in an exhaust passage (19, 22) of an internal combustion engine, the system comprising: an upstream side air-fuel ratio sensor to be provided in the exhaust passage at an upstream side of the exhaust purification catalyst in the direction of flow of exhaust; a downstream air-fuel ratio sensor to be provided in the exhaust passage at a downstream side of the exhaust purification catalyst in the direction of flow of exhaust; and a diagnosis device configured to diagnose the downstream air-fuel ratio sensor for abnormality based on outputs of the upstream and downstream air-fuel ratio sensors (40, 41), characterised in that the diagnosis device is configured to judge that the downstream air-fuel ratio sensor suffers from an abnormality if both: the output air-fuel ratio of the upstream side air-fuel ratio sensor becomes a rich air-fuel ratio, richer than a stoichiometric air-fuel ratio; and the output air-fuel ratio of the downstream air-fuel ratio sensor changes from i) an air-fuel ratio richer than a lean judged reference air-fuel ratio, leaner than the stoichiometric air-fuel ratio, to ii) an air-fuel ratio leaner than the lean judged reference air-fuel ratio. an upstream side air-fuel ratio sensor to be provided in the exhaust passage at an upstream side of the exhaust purification catalyst in the direction of flow of exhaust; a downstream air-fuel ratio sensor to be provided in the exhaust passage at a downstream side of the exhaust purification catalyst in the direction of flow of exhaust; and a diagnosis device configured to diagnose the downstream air-fuel ratio sensor for abnormality based on outputs of the upstream and downstream air-fuel ratio sensors (40, 41), characterised in that the diagnosis device is configured to judge that the downstream air-fuel ratio sensor suffers from an abnormality if both: the output air-fuel ratio of the upstream side air-fuel ratio sensor becomes a rich air-fuel ratio, richer than a stoichiometric air-fuel ratio; and the output air-fuel ratio of the downstream air-fuel ratio sensor changes from i) an air-fuel ratio richer than a lean judged reference air-fuel ratio, leaner than the stoichiometric air-fuel ratio, to ii) an air-fuel ratio leaner than the lean judged reference air-fuel ratio. the output air-fuel ratio of the upstream side air-fuel ratio sensor becomes a rich air-fuel ratio, richer than a stoichiometric air-fuel ratio; and the output air-fuel ratio of the downstream air-fuel ratio sensor changes from i) an air-fuel ratio richer than a lean judged reference air-fuel ratio, leaner than the stoichiometric air-fuel ratio, to ii) an air-fuel ratio leaner than the lean judged reference air-fuel ratio.
A back-drilling ancillary, for forming a recess in a bone, the back-drilling ancillary comprising at least: - one cutting tool comprising: i) a cutting portion configured to cut bone so as to form the recess, and ii) a rod secured in translation to the cutting portion, and - one reamer having a channel configured to house, at least partially, and to guide the rod in translation in a longitudinal direction, said reamer has two opposite ends comprising a proximal end (4.1) and a distal end (4.2) shaped so as to drill the bone, the reamer having a longitudinal groove, the longitudinal groove opening onto the channel, the longitudinal groove opening at the proximal end of the reamer, the cutting tool being introduced into the reamer by said proximal end, and the cutting portion being configured to project out of the longitudinal groove when the rod is guided in the channel along the longitudinal direction; the back-drilling ancillary being characterized in that the cutting portion is fixed relative to the rod. - one cutting tool comprising: i) a cutting portion configured to cut bone so as to form the recess, and ii) a rod secured in translation to the cutting portion, and - one reamer having a channel configured to house, at least partially, and to guide the rod in translation in a longitudinal direction, said reamer has two opposite ends comprising a proximal end (4.1) and a distal end (4.2) shaped so as to drill the bone,
Method for interim sterilisation of at least one surface in an insulator of a plant for treating containers during an interruption in operation, preferably in a beverage bottling plant, wherein the method has the steps of: applying a tempering fluid to at least one surface of the insulator in order to temper said surface, at least partially removing the tempering fluid from the insulator, treating the surface with a sterilising agent, and removing the sterilising agent after a specified exposure time, characterised in that the at least one surface of the insulator is brought by means of the tempering fluid to a temperature which is above the condensation point of the sterilising agent. applying a tempering fluid to at least one surface of the insulator in order to temper said surface, at least partially removing the tempering fluid from the insulator, treating the surface with a sterilising agent, and removing the sterilising agent after a specified exposure time, characterised in that the at least one surface of the insulator is brought by means of the tempering fluid to a temperature which is above the condensation point of the sterilising agent.
An isolated polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence having at least 90% identity thereto; or (iii) an immunogenic fragment of an Rv2386c protein sequence; wherein the Rv2386c protein sequence is selected from SEQ ID NO: 1 and 6; for use in: (a) the treatment of tuberculosis; (b) the treatment of latent tuberculosis; (c) the prevention of latent tuberculosis; (d) the prevention of reactivation of tuberculosis; or (e) the delay of reactivation of tuberculosis. (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence having at least 90% identity thereto; or (iii) an immunogenic fragment of an Rv2386c protein sequence; (a) the treatment of tuberculosis; (b) the treatment of latent tuberculosis; (c) the prevention of latent tuberculosis; (d) the prevention of reactivation of tuberculosis; or (e) the delay of reactivation of tuberculosis.
A dishwasher comprising: a housing having a bottom, a rear, and side covers; a door rotatably installed on a front surface of the housing; a door hinge installed onto each lower end of the door, while being rotatably coupled to the housing; a spring configured to adjust a rotation of the -door; and an apparatus to adjust the spring configured to adjust a load of the spring, wherein the apparatus comprises: a movable bracket connected to the spring; an adjustment member which enables the movable bracket to move up and down; an adjustment hole formed in the housing wherein the adjustment hole is configured to allow a tool for rotating the adjustment member to be inserted therethrough; and a support bracket (51, 52, 54) configured to support the adjustment member; wherein at least one position verification hole is perforated through the housing, the position verification hole adapted to check a vertical position of movement of the movable bracket from outside the housing wherein the apparatus is installed inside of the housing. a housing having a bottom, a rear, and side covers; a door rotatably installed on a front surface of the housing; a door hinge installed onto each lower end of the door, while being rotatably coupled to the housing; a spring configured to adjust a rotation of the -door; and an apparatus to adjust the spring configured to adjust a load of the spring, wherein the apparatus comprises: a movable bracket connected to the spring; an adjustment member which enables the movable bracket to move up and down; an adjustment hole formed in the housing wherein the adjustment hole is configured to allow a tool for rotating the adjustment member to be inserted therethrough; and a support bracket (51, 52, 54) configured to support the adjustment member; wherein a movable bracket connected to the spring; an adjustment member which enables the movable bracket to move up and down; an adjustment hole formed in the housing wherein the adjustment hole is configured to allow a tool for rotating the adjustment member to be inserted therethrough; and a support bracket (51, 52, 54) configured to support the adjustment member; wherein at least one position verification hole is perforated through the housing, the position verification hole adapted to check a vertical position of movement of the movable bracket from outside the housing wherein the apparatus is installed inside of the housing.