An inflatable package structure, formed by a plurality of air columns, wherein each of the air columns comprises heat sealing lines on two sides of an extending direction, the inflatable package structure is suitable for packaging, fixing and protecting a bottle, and the inflatable package structure further comprises: a bottom wall; a first fixing structure, comprising a first connecting portion and a first bending portion, wherein one end of the first connecting portion is connected to a top end of the bottom wall, a first heat sealing pitch line (a) is disposed at a joint between the first connecting portion and the bottom wall, the other end of the first connecting portion is connected to a first connecting end of the first bending portion, and a first extending end opposite to the first connecting end in the first bending portion is adhered to an upper surface of the bottom wall, a plurality of first heat sealing contacts is disposed on the heat sealing lines on the first extending end, and is adhered to the heat sealing lines of the bottom wall relatively adjacent to the top end, and the first bending portion comprises a first inner side surface wall and a first opening, and the first opening is disposed on the first inner side surface wall; and a second fixing structure, comprising a second connecting portion and a second bending portion, one end of the second connecting portion is connected to a bottom end of the bottom wall, and a second heat sealing pitch line (b) is disposed at a joint between the second connecting portion and the bottom wall, the other end of the second connecting portion is connected to a second connecting end of the second bending portion, and a second extending end opposite to the second connecting end in the second bending portion is adhered to the upper surface of the bottom wall, a plurality of second heat sealing contacts is disposed on the heat sealing lines on the second extending end, and is adhered to the heat sealing lines of the bottom wall relatively adjacent to the bottom end, and the second bending portion comprises a second inner side surface wall and a second opening, and the second opening is disposed on the second inner side surface wall; wherein, a diameter of the first opening is smaller than a diameter of the second opening, the first opening is configured for covering and fixing the upper part of the bottle, and the second opening is configured for covering and fixing the lower part of the bottle. a bottom wall; a first fixing structure, comprising a first connecting portion and a first bending portion, wherein one end of the first connecting portion is connected to a top end of the bottom wall, a first heat sealing pitch line (a) is disposed at a joint between the first connecting portion and the bottom wall, the other end of the first connecting portion is connected to a first connecting end of the first bending portion, and a first extending end opposite to the first connecting end in the first bending portion is adhered to an upper surface of the bottom wall, a plurality of first heat sealing contacts is disposed on the heat sealing lines on the first extending end, and is adhered to the heat sealing lines of the bottom wall relatively adjacent to the top end, and the first bending portion comprises a first inner side surface wall and a first opening, and the first opening is disposed on the first inner side surface wall; and a second fixing structure, comprising a second connecting portion and a second bending portion, one end of the second connecting portion is connected to a bottom end of the bottom wall, and a second heat sealing pitch line (b) is disposed at a joint between the second connecting portion and the bottom wall, the other end of the second connecting portion is connected to a second connecting end of the second bending portion, and a second extending end opposite to the second connecting end in the second bending portion is adhered to the upper surface of the bottom wall, a plurality of second heat sealing contacts is disposed on the heat sealing lines on the second extending end, and is adhered to the heat sealing lines of the bottom wall relatively adjacent to the bottom end, and the second bending portion comprises a second inner side surface wall and a second opening, and the second opening is disposed on the second inner side surface wall; wherein, a diameter of the first opening is smaller than a diameter of the second opening, the first opening is configured for covering and fixing the upper part of the bottle, and the second opening is configured for covering and fixing the lower part of the bottle.