A compound of formula IA having the structure: or a pharmaceutically acceptable salt thereof, wherein Y is -A-R 5, where A is a bond, --(CH 2) k -- or --(CD 2) k -- and R 5 is C 1 -C 6 linear or branched chain alkyl, C 3 -C 6 cycloalkyl, aryl, or --NR a' R b', or is an unsaturated, saturated or partially saturated monocyclic or bicyclic ring structure containing a total of five to eleven atoms having one to three heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur, wherein said alkyl, C 3 -C 6 cycloalkyl, aryl, or monocyclic or bicyclic ring structure is further optionally substituted with one or more substituents selected from the group consisting of deuterium, halo, C 1 -C 6 linear or branched chain alkyl, CN, hydroxyl, CF 3, --OR e, --NR e R f, --S p R e and C 3 -C 6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CONH 2, and SO 2 CH 3, where (a) R a, and R b, are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, C 3 -C 6 cycloalkyl, aryl, (C 1 -C 6 linear or branched chain alkyl)aryl, heteroaryl, or (C 1 -C 6 linear or branched chain alkyl)heteroaryl, where said alkyl and cycloalkyl may be optionally substituted with one or more R c', or (b) R a' and R b' together form a chain comprising --(CR c' R d') j --, where R c' and R d' are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, aryl, (C 1 -C 6 linear or branched chain alkyl)aryl, heteroaryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, halo, CN, hydroxyl, CF 3, CONH 2, --OR e, --NR e R f, or --S p R e; where R e and R f are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, or C 3 -C 6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CF 3, and CONH 2; j is 2, 3, 4 or 5; k is 1, 2; 3, or 4; and, p is 0, 1 or 2; in a pharmaceutically acceptable form in combination with one or more additional agents which modulate a mammalian immune system or which are anti-inflammatory. Y is -A-R 5, where A is a bond, --(CH 2) k -- or --(CD 2) k -- and R 5 is C 1 -C 6 linear or branched chain alkyl, C 3 -C 6 cycloalkyl, aryl, or --NR a' R b', or is an unsaturated, saturated or partially saturated monocyclic or bicyclic ring structure containing a total of five to eleven atoms having one to three heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur, wherein said alkyl, C 3 -C 6 cycloalkyl, aryl, or monocyclic or bicyclic ring structure is further optionally substituted with one or more substituents selected from the group consisting of deuterium, halo, C 1 -C 6 linear or branched chain alkyl, CN, hydroxyl, CF 3, --OR e, --NR e R f, --S p R e and C 3 -C 6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CONH 2, and SO 2 CH 3, where (a) R a, and R b, are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, C 3 -C 6 cycloalkyl, aryl, (C 1 -C 6 linear or branched chain alkyl)aryl, heteroaryl, or (C 1 -C 6 linear or branched chain alkyl)heteroaryl, where said alkyl and cycloalkyl may be optionally substituted with one or more R c', or (b) R a' and R b' together form a chain comprising --(CR c' R d') j --, where R c' and R d' are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, aryl, (C 1 -C 6 linear or branched chain alkyl)aryl, heteroaryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, halo, CN, hydroxyl, CF 3, CONH 2, --OR e, --NR e R f, or --S p R e; where R e and R f are independently hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, or C 3 -C 6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CF 3, and CONH 2; j is 2, 3, 4 or 5; k is 1, 2; 3, or 4; and, p is 0, 1 or 2;