mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing a pharmaceutically active compound containing a "CH 2 F" moiety on a sulphur atom, which method comprises the use of a monofluoromethylating reagent characterized by one of the following formulas I, II and III: wherein: R 1, R 2, R 3 is independently selected from the group consisting of hydrogen, alkyl or aryl; and R 4 is an anion suitable to form a salt of the reagents presented above, selected from the group consisting of tetrafluoroborate, triflate and halogen, wherein the pharmaceutically active is a compound of Formula IV: wherein: R is selected from the group consisting of hydroxyl, furoate and propionate. R 1, R 2, R 3 is independently selected from the group consisting of hydrogen, alkyl or aryl; and R 4 is an anion suitable to form a salt of the reagents presented above, selected from the group consisting of tetrafluoroborate, triflate and halogen, wherein the pharmaceutically active is a compound of Formula IV: wherein: R is selected from the group consisting of hydroxyl, furoate and propionate. R is selected from the group consisting of hydroxyl, furoate and propionate.
A composition for use in promoting tissue healing, and forming new hair and skin appendages, comprising: a porous scaffold comprising a pullulan-collagen hydrogel; and focal adhesion kinase inhibitor disposed in pores of the scaffold, wherein the composition is configured for sustained release of the FAK inhibitor disposed in pores of the scaffold to deliver a dose of the FAK inhibitor to the tissue effective to promote tissue healing at a controlled rate during a treatment time. a porous scaffold comprising a pullulan-collagen hydrogel; and focal adhesion kinase inhibitor disposed in pores of the scaffold, wherein the composition is configured for sustained release of the FAK inhibitor disposed in pores of the scaffold to deliver a dose of the FAK inhibitor to the tissue effective to promote tissue healing at a controlled rate during a treatment time.
Disc-shaped Particle comprising - a lipid binding polypeptide, - lipids and - a hydrophobic agent, wherein the particle does not comprise a hydrophilic or aqueous core, wherein the hydrophobic agent is neither a lipid nor a detergent, and wherein the lipid binding polypeptide is (a) a saposin-like protein (SAPLIP) belonging to the SAPLIP family of lipid interacting proteins or (b) a derivative form thereof, wherein the derivate is (i) a protein having at least 80 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6; (ii) a protein having at least 40 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6, wherein said protein is amphipathic, forms at least one alpha helix, and is capable of self-assembling together with solubilized lipids into lipoprotein particles when employed in the method of claim 10; or (iii) a protein comprising the sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6 in which 1 to 40 amino acids have been deleted, added, inserted and/or substituted. - a lipid binding polypeptide, - lipids and - a hydrophobic agent, (a) a saposin-like protein (SAPLIP) belonging to the SAPLIP family of lipid interacting proteins or (b) a derivative form thereof, wherein the derivate is (i) a protein having at least 80 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6; (ii) a protein having at least 40 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6, wherein said protein is amphipathic, forms at least one alpha helix, and is capable of self-assembling together with solubilized lipids into lipoprotein particles when employed in the method of claim 10; or (iii) a protein comprising the sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6 in which 1 to 40 amino acids have been deleted, added, inserted and/or substituted. (i) a protein having at least 80 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6; (ii) a protein having at least 40 % sequence identity to the full length sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6, wherein said protein is amphipathic, forms at least one alpha helix, and is capable of self-assembling together with solubilized lipids into lipoprotein particles when employed in the method of claim 10; or (iii) a protein comprising the sequence of SEQ ID NO. 1, 2, 3, 4, 5 or 6 in which 1 to 40 amino acids have been deleted, added, inserted and/or substituted.
An acoustic panel system, comprising: a perforated first skin; a second skin; and a core connected to the perforated first skin and the second skin, the core including a plurality of chambers and a first constriction; and an actuator configured to remotely actuate deformation of the first constriction, each of the plurality of chambers extending vertically through the core between the perforated first skin and the second skin, and the plurality of chambers comprising a first chamber; the first constriction configured to divide the first chamber into a plurality of fluidly coupled sub-chambers (46A, 46B), and the first constriction comprising a shape memory material; wherein the first constriction includes and extends vertically between a first end and a second end; wherein the first end is attached to a sidewall of the first chamber, and characterised in that an intermediate portion of the first constriction, vertically between the first end and the second end, is not attached to the sidewall of the first chamber such that the intermediate portion of the first constriction is configured to move laterally away from the sidewall of the first chamber when actuated by the actuator. a perforated first skin; a second skin; and a core connected to the perforated first skin and the second skin, the core including a plurality of chambers and a first constriction; and an actuator configured to remotely actuate deformation of the first constriction, each of the plurality of chambers extending vertically through the core between the perforated first skin and the second skin, and the plurality of chambers comprising a first chamber; the first constriction configured to divide the first chamber into a plurality of fluidly coupled sub-chambers (46A, 46B), and the first constriction comprising a shape memory material; wherein the first constriction includes and extends vertically between a first end and a second end; wherein the first end is attached to a sidewall of the first chamber, and characterised in that an intermediate portion of the first constriction, vertically between the first end and the second end, is not attached to the sidewall of the first chamber such that the intermediate portion of the first constriction is configured to move laterally away from the sidewall of the first chamber when actuated by the actuator.
A pocket spring string, comprising springs; cloth, folded and provided with welds to form multiple adjacent pockets, a top and/or bottom of each said pocket being provided with an opening, and the springs being received in the pockets respectively; and thread, provided at the top and/or the bottom of each said pocket in a length direction of the pocket spring string, to stitch the openings so that the springs are packaged in the pockets in a compressed state; wherein the thread is detachably stitched and the thread is of a continuous structure; wherein when the thread is removed, the springs extend out of the openings under their own elastic force. springs; cloth, folded and provided with welds to form multiple adjacent pockets, a top and/or bottom of each said pocket being provided with an opening, and the springs being received in the pockets respectively; and thread, provided at the top and/or the bottom of each said pocket in a length direction of the pocket spring string, to stitch the openings so that the springs are packaged in the pockets in a compressed state; wherein the thread is detachably stitched and the thread is of a continuous structure; wherein when the thread is removed, the springs extend out of the openings under their own elastic force.
A method for augmented interaction between a first user and a second user, the method comprising: capturing information with a first human interface module; processing the information captured by the first human interface module; retrieving a set of shared information based upon the processing of the information captured by the first human interface module; presenting the shared set of information overlaid upon a field of view of the first user using the first human interface module; and presenting the shared set of information overlaid upon a field of view of the second user using a second human interface module; characterized by determining whether the shared set of information relates to a new process, wherein if it is determined that the shared set of information relates to a new process on which the first user is to be trained, the step of capturing information with the first human interface module includes recording the first user performing an action of the new process; and processing the captured information for consistency with the new process; and generating a first notification and sending the first notification to the first human interface module if the information captured by the first human interface module is inconsistent with the new process beyond a first tolerance level; and generating a second notification and sending the second notification to the second human interface module if the information captured by the first human interface module is inconsistent with the new process beyond a second tolerance level. capturing information with a first human interface module; processing the information captured by the first human interface module; retrieving a set of shared information based upon the processing of the information captured by the first human interface module; presenting the shared set of information overlaid upon a field of view of the first user using the first human interface module; and presenting the shared set of information overlaid upon a field of view of the second user using a second human interface module; characterized by determining whether the shared set of information relates to a new process, wherein if it is determined that the shared set of information relates to a new process on which the first user is to be trained, the step of capturing information with the first human interface module includes recording the first user performing an action of the new process; and processing the captured information for consistency with the new process; and generating a first notification and sending the first notification to the first human interface module if the information captured by the first human interface module is inconsistent with the new process beyond a first tolerance level; and generating a second notification and sending the second notification to the second human interface module if the information captured by the first human interface module is inconsistent with the new process beyond a second tolerance level.
A composition to be used for the manufacture of mono- or multilayer films for personal hygiene and food wrap applications, comprising from 5 to 40 wt% of a styrenic block copolymer, having a molecular structure according to the general formulae S - EB - S or (S - EB) n X, wherein each S independently is a polymer block of at least 95 wt% of styrene and minor amounts of other comonomers and EB is a hydrogenated polymer block of at least 95 wt% of butadiene and minor amounts of other comonomers, n is an integer equal to or greater than 2, and X is the residue of a coupling agent, having a poly(styrene) content of from 10 to 29 wt% and preferably from 17 to 24 wt%, having poly(styrene) blocks of an apparent molecular weight M w in the range of from 6,000 to 9,000, having an apparent molecular weight M w of the complete block copolymer in the range of from 80,000 to 150,000, wherein the apparent molecular weight is determined by Gel Permeation Chromatography according to the description, having an 1,2-addition degree (vinyl content) in the precursor of the poly(butadiene) block in the range of from 60 to 80% (mole/mole), wherein the block EB has a hydrogenation degree of at least 80% and preferably at least 90% and wherein diblock S-EB optionally occurs in a content of at most 20 mole% and preferably at most 10 mole%, a random propylene copolymer with a flexural modulus smaller than 300 MPa according to ASTM D-790, in an amount of at least 40 wt% and optionally a resin which is compatible with the hydrogenated poly(butadiene) blocks in an amount of from 0 to 25 %wt, wherein all weight percentages are relative to the weight of the complete composition. wherein each S independently is a polymer block of at least 95 wt% of styrene and minor amounts of other comonomers and EB is a hydrogenated polymer block of at least 95 wt% of butadiene and minor amounts of other comonomers, n is an integer equal to or greater than 2, and X is the residue of a coupling agent, having a poly(styrene) content of from 10 to 29 wt% and preferably from 17 to 24 wt%, having poly(styrene) blocks of an apparent molecular weight M w in the range of from 6,000 to 9,000, having an apparent molecular weight M w of the complete block copolymer in the range of from 80,000 to 150,000, wherein the apparent molecular weight is determined by Gel Permeation Chromatography according to the description, having an 1,2-addition degree (vinyl content) in the precursor of the poly(butadiene) block in the range of from 60 to 80% (mole/mole), wherein the block EB has a hydrogenation degree of at least 80% and preferably at least 90% and wherein diblock S-EB optionally occurs in a content of at most 20 mole% and preferably at most 10 mole%, a random propylene copolymer with a flexural modulus smaller than 300 MPa according to ASTM D-790, in an amount of at least 40 wt% and optionally a resin which is compatible with the hydrogenated poly(butadiene) blocks in an amount of from 0 to 25 %wt, wherein all weight percentages are relative to the weight of the complete composition.
Connection piece for an enteral transfer system having a distal attachment piece for attaching a connection piece of a probe tube of an enteral feed probe and a proximal attachment piece for attaching the connection tube of a transfer system, the distal attachment piece being designed stepped, having a plurality of sections (11A, 11B, 11C, 11D) with different diameters, so that a detachable connection can be effected using funnel-shaped connection pieces having different diameters from the probe tubes of different feed probes, characterized in that a foremost section of the distal attachment piece having the smallest diameter has a distal connection cone which is designed as an outer cone and is adjoined proximally by a section designed as a locking element, wherein the locking element of the distal attachment piece is designed as a screw connection element or as a bayonet connection element or as a bayonet connection element, so that the distal attachment piece is designed in such a fashion that, firstly, an interlocking detachable connection can be effected to a connection piece of a probe tube of an enteral feed probe having a complementary locking element to the locking element of the distal attachment piece, and that, secondly, a detachable connection can be effected using funnel-shaped connection pieces having different diameters from the probe tubes of different feed probes.
Low energy method for preparing a non-derivatised nanocellulose material comprising (a) treating a cellulosic material with a swelling agent to obtain swollen cellulosic material, (b) subjecting said swollen cellulosic material to effective mechanical comminution processing, such as high shear forces, high pressure homogenization, microfluidization, high friction forces, and combinations thereof, and (c) isolating the nanocellulose material, wherein the swelling agent is a swelling agent disrupting intercrystalline regions only and wherein the cellulosic material is characterized by a swelling index of between 1.5 to 3 in said swelling agent And further wherein the swelling agent is an aqueous solution of morpholine, piperidine or mixtures thereof comprising of from 70 to 99% (by volume) of morpholine, piperidine or mixtures thereof, respectively.
A headrest removal assembly, the headrest removal assembly comprising: a plunger including a plunger shaft, the plunger shaft including a first end and a second end, the plunger including a lever portion positioned between the first end and the second end of the plunger shaft, a cavity within a base configured to house at least a portion of the plunger shaft; a compressible spring coupled to the second end of the plunger shaft and configured to surround at least a portion of the plunger shaft, the cavity configured to house at least a portion of the compressible spring; and a stopper configured to couple to the first end of the plunger shaft, the stopper configured to engage with a cavity within a headrest support plate, the plunger configured to translate the stopper between at least a first stopper position and a second stopper position when a force is applied to the lever portion of the plunger to cause the plunger to compress a portion of the compressible spring within the cavity of the base to cause the stopper to disengage from the cavity within the headrest support plate to cause the headrest removal assembly to disengage from the headrest support plate. a plunger including a plunger shaft, the plunger shaft including a first end and a second end, the plunger including a lever portion positioned between the first end and the second end of the plunger shaft, a cavity within a base configured to house at least a portion of the plunger shaft; a compressible spring coupled to the second end of the plunger shaft and configured to surround at least a portion of the plunger shaft, the cavity configured to house at least a portion of the compressible spring; and a stopper configured to couple to the first end of the plunger shaft, the stopper configured to engage with a cavity within a headrest support plate, the plunger configured to translate the stopper between at least a first stopper position and a second stopper position when a force is applied to the lever portion of the plunger to cause the plunger to compress a portion of the compressible spring within the cavity of the base to cause the stopper to disengage from the cavity within the headrest support plate to cause the headrest removal assembly to disengage from the headrest support plate.
A laser welding system comprising: a laser welding unit comprising a nozzle for emitting a laser beam and configured to perform welding along a junction (63, 67, 69) of objects to be welded, said junction (36, 37, 69) forming a corner, by relatively moving the objects to be welded and the nozzle; and a holding unit configured to movably hold the nozzle while applying a biasing force to the nozzle in a direction toward the junction (63, 67, 69) such that the nozzle comes into contact with the objects to be welded to irradiate the junction (63, 67, 69) with the laser beam, characterized in that the holding unit rotatably holds a rear end portion of the laser welding unit, and a leading end portion of the laser welding unit is connected to the holding unit via an elastic member that provides the biasing force to the nozzle. a laser welding unit comprising a nozzle for emitting a laser beam and configured to perform welding along a junction (63, 67, 69) of objects to be welded, said junction (36, 37, 69) forming a corner, by relatively moving the objects to be welded and the nozzle; and a holding unit configured to movably hold the nozzle while applying a biasing force to the nozzle in a direction toward the junction (63, 67, 69) such that the nozzle comes into contact with the objects to be welded to irradiate the junction (63, 67, 69) with the laser beam, characterized in that the holding unit rotatably holds a rear end portion of the laser welding unit, and a leading end portion of the laser welding unit is connected to the holding unit via an elastic member that provides the biasing force to the nozzle.
Lifting apparatus, with a lifting part which is movable in a lifting direction between a working position and a rest position, and on which a supporting unit for supporting a workpiece and/or a clamping unit for clamping a workpiece is arranged, with at least one drive device arranged on a base part and having a toggle lever mechanism and a drive coupled to the toggle lever mechanism, wherein the toggle lever mechanism comprises a first toggle lever connected pivotably to the lifting part and a second toggle lever connected pivotably to the base part, the toggle levers (22a, 22b) being connected together at a toggle joint, characterized in that it has a positioning device which defines the working position of the lifting part such that the toggle levers (22a, 22b) are outside their extended position and enclose a toggle lever angle (α) of less than 180°, wherein the positioning device has a stop face which faces the lifting part and in the working position lies against a stop face of the lifting part, and wherein the positioning device has a pillar which, starting from the base part, extends through a recess in the lifting part and has a stop part with the stop face at its end facing away from the base part.
A monitoring device positioned to monitor a cargo hold of a transport vehicle, comprising: an RF transceiver implementing a first wireless communication protocol; a processor; and memory storing machine-readable instructions that, when executed by the processor, cause the processor to: transmit a location of the monitoring device to a server of a tracking system including the monitoring device; receive, in response, an identifier of the transport vehicle nearest to the wireless monitoring device; receive a wireless signal containing a tracking identifier from a wireless tracking tag attached to a logistic container being conveyed into the cargo hold of the transport vehicle; determine a signal strength of the wireless signal; and transmit an alert to a network service when the signal strength indicates that the wireless tracking tag was not successfully loaded into the cargo hold of the transport vehicle. an RF transceiver implementing a first wireless communication protocol; a processor; and memory storing machine-readable instructions that, when executed by the processor, cause the processor to: transmit a location of the monitoring device to a server of a tracking system including the monitoring device; receive, in response, an identifier of the transport vehicle nearest to the wireless monitoring device; receive a wireless signal containing a tracking identifier from a wireless tracking tag attached to a logistic container being conveyed into the cargo hold of the transport vehicle; determine a signal strength of the wireless signal; and transmit an alert to a network service when the signal strength indicates that the wireless tracking tag was not successfully loaded into the cargo hold of the transport vehicle. transmit a location of the monitoring device to a server of a tracking system including the monitoring device; receive, in response, an identifier of the transport vehicle nearest to the wireless monitoring device; receive a wireless signal containing a tracking identifier from a wireless tracking tag attached to a logistic container being conveyed into the cargo hold of the transport vehicle; determine a signal strength of the wireless signal; and transmit an alert to a network service when the signal strength indicates that the wireless tracking tag was not successfully loaded into the cargo hold of the transport vehicle.