A device for binding a target entity onto a bait entity that is immobilized on said device, comprising: a) a lipid layer which comprises one or more lipids, said lipid layer having a negative net charge in an aqueous solution at a neutral pH; b) a two-dimensional matrix of anchoring complexes that are bound to said lipid layer, wherein each of said anchoring complexes comprises: (i) a fusion complex comprising an Annexin protein selected from the group consisting of Annexin A4, Annexin A5 and Annexin A12, fused to a partner molecule, wherein: - said Annexin protein is bound through specific and non-covalent binding to said lipid layer, and - said partner molecule consists of an organic compound; (ii) a bait entity selected from the group consisting of: - said partner molecule that is fused to said Annexin protein; - a molecule that is covalently or non-covalently bound to said partner molecule; - a molecule that is indirectly bound to said partner molecule through one or more intermediate molecules that are covalently or non-covalently bound to said partner molecule. a) a lipid layer which comprises one or more lipids, said lipid layer having a negative net charge in an aqueous solution at a neutral pH; b) a two-dimensional matrix of anchoring complexes that are bound to said lipid layer, wherein each of said anchoring complexes comprises: (i) a fusion complex comprising an Annexin protein selected from the group consisting of Annexin A4, Annexin A5 and Annexin A12, fused to a partner molecule, wherein: - said Annexin protein is bound through specific and non-covalent binding to said lipid layer, and - said partner molecule consists of an organic compound; (ii) a bait entity selected from the group consisting of: - said partner molecule that is fused to said Annexin protein; - a molecule that is covalently or non-covalently bound to said partner molecule; - a molecule that is indirectly bound to said partner molecule through one or more intermediate molecules that are covalently or non-covalently bound to said partner molecule. (i) a fusion complex comprising an Annexin protein selected from the group consisting of Annexin A4, Annexin A5 and Annexin A12, fused to a partner molecule, wherein: - said Annexin protein is bound through specific and non-covalent binding to said lipid layer, and - said partner molecule consists of an organic compound; - said Annexin protein is bound through specific and non-covalent binding to said lipid layer, and - said partner molecule consists of an organic compound; (ii) a bait entity selected from the group consisting of: - said partner molecule that is fused to said Annexin protein; - a molecule that is covalently or non-covalently bound to said partner molecule; - a molecule that is indirectly bound to said partner molecule through one or more intermediate molecules that are covalently or non-covalently bound to said partner molecule. - said partner molecule that is fused to said Annexin protein; - a molecule that is covalently or non-covalently bound to said partner molecule; - a molecule that is indirectly bound to said partner molecule through one or more intermediate molecules that are covalently or non-covalently bound to said partner molecule.