A method for detecting an analyte in a sample, comprising: contacting an analyte and optionally a tag-linked analyte, a first recognition component, and a second recognition component linked with an amplification element to generate a complex comprising the first recognition component and the second recognition component linked with the amplification element, wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component, wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component; and wherein the second recognition component is conjugated to a first binding partner, the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner, and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); contacting the amplification element linked with an amplification precursor under conditions to convert the amplification precursor into a molecule that adds mass at a surface of the TFBAR; and measuring mass added at the surface of the TFBAR. contacting an analyte and optionally a tag-linked analyte, a first recognition component, and a second recognition component linked with an amplification element to generate a complex comprising the first recognition component and the second recognition component linked with the amplification element, wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component, wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component; and wherein the second recognition component is conjugated to a first binding partner, the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner, and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component, wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component; and wherein the second recognition component is conjugated to a first binding partner, the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner, and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); contacting the amplification element linked with an amplification precursor under conditions to convert the amplification precursor into a molecule that adds mass at a surface of the TFBAR; and measuring mass added at the surface of the TFBAR.