A pixel driving method, comprising steps of: obtaining a brightness sum of a frame of picture according to a brightness of each of pixels in the frame of picture; inquiring a data voltage compensation value corresponding to the obtained brightness sum from a first correspondence relationship, the first correspondence relationship comprising a one-to-one correspondence relationship between the brightness sum and the data voltage compensation value for one frame of picture; compensating a data voltage of the pixels in a sensing row of the frame of picture or a data voltage of all the pixels in the frame of picture according to the data voltage compensation value to generate a compensated data voltage; and outputting the compensated data voltage to a display panel, wherein the method is characterized in that: before the step of obtaining a brightness sum of a frame of picture according to a brightness of each of pixels in the frame of picture, the method further comprises steps of: establishing a second correspondence relationship, the second correspondence relationship comprising a one-to-one correspondence relationship between the brightness sum and a voltage difference average value of pixels for one frame of picture, and the voltage difference average value being an average value of sensing voltages of all or a part of the pixels in the one frame of picture; establishing a third correspondence relationship, the third correspondence relationship comprising a one-to-one correspondence relationship between the voltage difference average value of pixels and the data voltage compensation value for one frame of picture; and generating the first correspondence relationship according to the second correspondence relationship and the third correspondence relationship. obtaining a brightness sum of a frame of picture according to a brightness of each of pixels in the frame of picture; inquiring a data voltage compensation value corresponding to the obtained brightness sum from a first correspondence relationship, the first correspondence relationship comprising a one-to-one correspondence relationship between the brightness sum and the data voltage compensation value for one frame of picture; compensating a data voltage of the pixels in a sensing row of the frame of picture or a data voltage of all the pixels in the frame of picture according to the data voltage compensation value to generate a compensated data voltage; and outputting the compensated data voltage to a display panel, wherein the method is characterized in that: before the step of obtaining a brightness sum of a frame of picture according to a brightness of each of pixels in the frame of picture, the method further comprises steps of: establishing a second correspondence relationship, the second correspondence relationship comprising a one-to-one correspondence relationship between the brightness sum and a voltage difference average value of pixels for one frame of picture, and the voltage difference average value being an average value of sensing voltages of all or a part of the pixels in the one frame of picture; establishing a third correspondence relationship, the third correspondence relationship comprising a one-to-one correspondence relationship between the voltage difference average value of pixels and the data voltage compensation value for one frame of picture; and generating the first correspondence relationship according to the second correspondence relationship and the third correspondence relationship. establishing a second correspondence relationship, the second correspondence relationship comprising a one-to-one correspondence relationship between the brightness sum and a voltage difference average value of pixels for one frame of picture, and the voltage difference average value being an average value of sensing voltages of all or a part of the pixels in the one frame of picture; establishing a third correspondence relationship, the third correspondence relationship comprising a one-to-one correspondence relationship between the voltage difference average value of pixels and the data voltage compensation value for one frame of picture; and generating the first correspondence relationship according to the second correspondence relationship and the third correspondence relationship.