Method of designing and manufacturing a reverse shoe last and a straight shoe last used for manufacturing an article of footwear by means of a process that provides for fixing an upper disposed in reverse position on the reverse shoe last to a midsole; said method comprising the following steps: - designing a shape and/or size of a foot suitable for wearing the article of footwear to be manufactured; - designing and making a reverse shoe last whereon the upper is suitable for being disposed in reverse position during the fixing of the upper to the midsole; - designing and making a straight shoe last suitable for being inserted inside the upper when the upper has been turned and disposed in straight position; wherein said straight shoe last is designed and made in such a way to substantially have the same shape as the foot; wherein said reverse shoe last is designed and made with a higher length than the length of the straight shoe last; characterized in that said reverse shoe last and said straight shoe last are designed and made with instep-toe profiles (cp1, cp2) that extend along two different trajectories. wherein said instep-toe profile (cp1, cp2) of the reverse shoe last and of the straight shoe last comprises an end section (10, 20) in correspondence of the toe (p1, p2) of the shoe last (1, 2); wherein said reverse shoe last and said straight shoe last comprise a sole with a final section (11, 21) in correspondence of the toe (p1, p2); said final section (11, 21) being joined with said end section (10, 20) of the shoe last (1, 2); wherein said end section and said final section of the reverse shoe last define an angle (α) comprised between 52° and 62°; wherein said end section and said final section of the straight shoe last define an angle (β) comprised between 80° and 89°. - designing a shape and/or size of a foot suitable for wearing the article of footwear to be manufactured; - designing and making a reverse shoe last whereon the upper is suitable for being disposed in reverse position during the fixing of the upper to the midsole; - designing and making a straight shoe last suitable for being inserted inside the upper when the upper has been turned and disposed in straight position; wherein said straight shoe last is designed and made in such a way to substantially have the same shape as the foot; wherein said reverse shoe last is designed and made with a higher length than the length of the straight shoe last; characterized in that said reverse shoe last and said straight shoe last are designed and made with instep-toe profiles (cp1, cp2) that extend along two different trajectories. wherein said instep-toe profile (cp1, cp2) of the reverse shoe last and of the straight shoe last comprises an end section (10, 20) in correspondence of the toe (p1, p2) of the shoe last (1, 2); wherein said reverse shoe last and said straight shoe last comprise a sole with a final section (11, 21) in correspondence of the toe (p1, p2); said final section (11, 21) being joined with said end section (10, 20) of the shoe last (1, 2); wherein said end section and said final section of the reverse shoe last define an angle (α) comprised between 52° and 62°; wherein said end section and said final section of the straight shoe last define an angle (β) comprised between 80° and 89°.