A filter cartridge assembly comprising: a filter cartridge body defining a filter securing frame; at least one filter or filter media received and held in the filter securing frame; at least one tri-clamp flange adapter formed on, or attached to, an end of the filter cartridge body, wherein the at least one tri-clamp flange adapter defines a lumen in fluid communication with the filter securing frame, wherein the at least one tri-clamp flange adapter has one tri-clamp flange adapter port and wherein an end of the tri-clamp flange adapter port distal from the filter cartridge body is formed with a radially extending flange end; and, a metallic or polymer based flange insert secured in or about the radially extending flange end, wherein flange insert comprises a substantially circular body being generally planar or frustoconical in cross-section, wherein the circular body has a substantially annular, axially extended perimeter shoulder, i.e., a substantially annular, axially extended perimeter rim, wherein a portion of the circular body defines a central insert bore, wherein the flange insert has a top annular planar surface exposed to form an annular flange registration surface, wherein the material used to form the filter cartridge body and the at least one tri-clamp flange adapter port and the radially extended flange end forms a top portion of the radially extended flanged end which top portion defines an annular, substantially planar gasket body support and registration surface that partially defines the lumen, wherein the radially extended flanged end has a segment between insert rim and gasket registration surface that defines an annular flange channel to receive a gasket shoulder, wherein the radially outer annular edge of the channel is defined by a radially inner annular surface of the rim, wherein a transition from gasket registration surface to flange channel is defined as an annular slope that presents a smooth transition, and wherein a transition from rim to flange channel is defined as a radially distal annular radiused slope to provide support for a gasket in a manner that does not create any angular edges. a filter cartridge body defining a filter securing frame; at least one filter or filter media received and held in the filter securing frame; at least one tri-clamp flange adapter formed on, or attached to, an end of the filter cartridge body, wherein the at least one tri-clamp flange adapter defines a lumen in fluid communication with the filter securing frame, wherein the at least one tri-clamp flange adapter has one tri-clamp flange adapter port and wherein an end of the tri-clamp flange adapter port distal from the filter cartridge body is formed with a radially extending flange end; and, a metallic or polymer based flange insert secured in or about the radially extending flange end, wherein flange insert comprises a substantially circular body being generally planar or frustoconical in cross-section, wherein the circular body has a substantially annular, axially extended perimeter shoulder, i.e., a substantially annular, axially extended perimeter rim, wherein a portion of the circular body defines a central insert bore, wherein the flange insert has a top annular planar surface exposed to form an annular flange registration surface, wherein the material used to form the filter cartridge body and the at least one tri-clamp flange adapter port and the radially extended flange end forms a top portion of the radially extended flanged end which top portion defines an annular, substantially planar gasket body support and registration surface that partially defines the lumen, wherein the radially extended flanged end has a segment between insert rim and gasket registration surface that defines an annular flange channel to receive a gasket shoulder, wherein the radially outer annular edge of the channel is defined by a radially inner annular surface of the rim, wherein a transition from gasket registration surface to flange channel is defined as an annular slope that presents a smooth transition, and wherein a transition from rim to flange channel is defined as a radially distal annular radiused slope to provide support for a gasket in a manner that does not create any angular edges.