A physiological monitoring system (100, 100') for determining a physiological parameter of a human subject engaging in a first low level of activity and engaging in a second high level of activity, wherein the system comprises: a. a low energy sensor for transcutaneous sampling of the physiological parameter from the human subject and for producing a first physiological sensor signal; b. a high energy sensor for transcutaneous sampling of the physiological parameter from the human subject and for producing a second physiological sensor signal; c. a motion sensor for sampling a motion parameter from the human subject and for producing a motion reference signal; d. a microprocessor, wherein the microprocessor is configured to selectively activate sampling activity of the high energy sensor and the low energy sensor via a switch mechanism and wherein the switch mechanism is configured, based on the motion reference signal, to select the low energy sensor to determine the physiological parameter during a period of the first low level of activity and to select the high energy sensor to determine the physiological parameter during a period of the second high level of activity, and wherein the microprocessor is configured to select both the high energy sensor and the low energy sensor for short periods of time to ensure stable activation transition during a transition between activation of the low energy sensor and activation of the high energy sensor induced by a change in the activity level of the human subject from a low activity level threshold to a high activity level threshold and a transition between activation of the high energy sensor and activation of the low energy sensor induced by a change in the activity level of the human subject from a high activity level threshold to a low activity level threshold. a. a low energy sensor for transcutaneous sampling of the physiological parameter from the human subject and for producing a first physiological sensor signal; b. a high energy sensor for transcutaneous sampling of the physiological parameter from the human subject and for producing a second physiological sensor signal; c. a motion sensor for sampling a motion parameter from the human subject and for producing a motion reference signal; d. a microprocessor, wherein the microprocessor is configured to selectively activate sampling activity of the high energy sensor and the low energy sensor via a switch mechanism and wherein the switch mechanism is configured, based on the motion reference signal, to select the low energy sensor to determine the physiological parameter during a period of the first low level of activity and to select the high energy sensor to determine the physiological parameter during a period of the second high level of activity, and wherein the microprocessor is configured to select both the high energy sensor and the low energy sensor for short periods of time to ensure stable activation transition during a transition between activation of the low energy sensor and activation of the high energy sensor induced by a change in the activity level of the human subject from a low activity level threshold to a high activity level threshold and a transition between activation of the high energy sensor and activation of the low energy sensor induced by a change in the activity level of the human subject from a high activity level threshold to a low activity level threshold.