mhurhangee/ep-ind-claims huggingface dataset:
Process for the preparation of a compound of Formula wherein X and Y independently are optionally substituted heteroatoms; each R 2 independently is H, alkyl, alkenyl or aryl; R 3 and R 4 independently are H or -CN, provided that at least one of R 3 and R 4 is -CN; a.) which comprises dehydration/aromatization of a compound of the Formula X and Y independently are optionally substituted heteroatoms; R is a C 1-4 alkylene group which may optionally be substituted with one or more R 1; R 1 is a linear, branched and/or cyclic, saturated or unsaturated hydrocarbon group which optionally bears one or more functional groups; R 2 independently is H, alkyl, alkenyl or aryl; and R 3 and R 4 independently are H or -CN, provided that at least one of R 3 and R 4 is -CN; and to obtain a compound of the Formula wherein X, Y, R, R 2, R 3 and R 4 are defined as above; followed by deprotection of the compound of Formula; or b.) which comprises carrying out the dehydration/aromatization and the deprotection of the compound of Formula in a single step. X and Y independently are optionally substituted heteroatoms; each R 2 independently is H, alkyl, alkenyl or aryl; R 3 and R 4 independently are H or -CN, provided that at least one of R 3 and R 4 is -CN; a.) which comprises dehydration/aromatization of a compound of the Formula X and Y independently are optionally substituted heteroatoms; R is a C 1-4 alkylene group which may optionally be substituted with one or more R 1; R 1 is a linear, branched and/or cyclic, saturated or unsaturated hydrocarbon group which optionally bears one or more functional groups; R 2 independently is H, alkyl, alkenyl or aryl; and R 3 and R 4 independently are H or -CN, provided that at least one of R 3 and R 4 is -CN; and to obtain a compound of the Formula wherein X, Y, R, R 2, R 3 and R 4 are defined as above; followed by deprotection of the compound of Formula; or X and Y independently are optionally substituted heteroatoms; R is a C 1-4 alkylene group which may optionally be substituted with one or more R 1; R 1 is a linear, branched and/or cyclic, saturated or unsaturated hydrocarbon group which optionally bears one or more functional groups; R 2 independently is H, alkyl, alkenyl or aryl; and R 3 and R 4 independently are H or -CN, provided that at least one of R 3 and R 4 is -CN; and to obtain a compound of the Formula wherein X, Y, R, R 2, R 3 and R 4 are defined as above; followed by deprotection of the compound of Formula; or b.) which comprises carrying out the dehydration/aromatization and the deprotection of the compound of Formula in a single step.
Clamping device for clamping a cylindrical tool shaft, in particular of a dental tool, comprising a spring element for holding the tool shaft, a hollow shaft for transmitting a rotational movement, and a plunger, wherein the spring element is configured as a sleeve having a cylindrical wall, a first opening and a second opening and the wall comprises recesses, wherein the spring element, the shaft and the plunger have coaxially disposed rotational axes, the shaft projects at least partially into the first opening of the spring element in order to expand the spring element and the plunger projects at least partially into the second opening of the springloaded element in order to expand the spring element, and the spring element is connected to the shaft in a form-fitting or force-fitting manner.
A method for purifying a recombinant tumor necrosis factor receptor Fc (TNFR-Fc) fusion protein, preferably etanercept, from a sample containing the recombinant protein and a second protein that binds to the protein, comprising subjecting the sample to a tentacle anion exchange matrix chromatography medium under conditions whereby the recombinant protein binds to the tentacle anion exchange matrix chromatography medium, followed by eluting the recombinant protein bound to the chromatography medium in an eluant, whereby at least 85% of the recombinant protein is recovered in the eluant and at least 75% of the second protein is removed from the eluant; wherein a) the second protein is Protein A or Protein G; and b) the tentacle anion exchange matrix chromatography medium contains trimethylammoniumethyl (TMAE). a) the second protein is Protein A or Protein G; and b) the tentacle anion exchange matrix chromatography medium contains trimethylammoniumethyl (TMAE).
A radical-polymerizable resin composition comprising one or more metal-containing compounds selected from a metal soap and a β-diketone skeleton-containing metal complex, wherein the metal element constituting the one or more metal-containing compounds is at least one of selected from zirconium, manganese, cobalt, bismuth, and calcium; one or more thiol compounds selected from a secondary thiol compound and a tertiary thiol compound, wherein the molar ratio of the thiol compound to the metal component of the metal-containing compound each in terms of the total amount [ /] is from 0.1 to 150); a radical-polymerizable compound selected from a vinyl ester resin (epoxy (meth)acrylate resin), an unsaturated polyester resin, a polyester (meth)acrylate resin, a urethane (meth)acrylate resin, a (meth)acrylate resin, a radical-polymerizable unsaturated monomer having a vinyl group or a (meth)acryloyl group, and a mixture of the resin and the radical-polymerizable unsaturated monomer; and an elastomer. one or more metal-containing compounds selected from a metal soap and a β-diketone skeleton-containing metal complex, wherein the metal element constituting the one or more metal-containing compounds is at least one of selected from zirconium, manganese, cobalt, bismuth, and calcium; one or more thiol compounds selected from a secondary thiol compound and a tertiary thiol compound, wherein the molar ratio of the thiol compound to the metal component of the metal-containing compound each in terms of the total amount [ /] is from 0.1 to 150); a radical-polymerizable compound selected from a vinyl ester resin (epoxy (meth)acrylate resin), an unsaturated polyester resin, a polyester (meth)acrylate resin, a urethane (meth)acrylate resin, a (meth)acrylate resin, a radical-polymerizable unsaturated monomer having a vinyl group or a (meth)acryloyl group, and a mixture of the resin and the radical-polymerizable unsaturated monomer; and an elastomer.
A blood line for extracorporeal blood or plasma treatment comprising: - a first line portion intended to be connected to the outlet of a filter, - a second line portion intended to be connected to a patient's vascular access, - an infusion site acting between the first line portion and the second line portion, and intended to inject into the blood line a solution reestablishing blood or plasma ion balance, comprising: - a first main channel in fluid communication with the first line portion and having a first passage section, - a second main channel in fluid communication with the second line portion and having a second passage section, - means for the formation of a turbulence area located downstream from and in fluid communication with the first main channel, located upstream from and in fluid communication with the second main channel, these formation means comprising a first fluid passage means defining a reduction in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, - a secondary channel comprising an inlet for letting in a solution reestablishing ion balance and an outlet in fluid communication with at least one of the three elements chosen among the first main channel, the means for the formation of a turbulence area and the second main channel; characterized in that the turbulence area formation means include a second fluid passage means downstream from the first fluid passage means defining an increase in fluid passage section in the sense of fluid passage and the largest fluid passage section of the second fluid passage means is smaller than said first passage section and smaller than said second passage section. - a first line portion intended to be connected to the outlet of a filter, - a second line portion intended to be connected to a patient's vascular access, - an infusion site acting between the first line portion and the second line portion, and intended to inject into the blood line a solution reestablishing blood or plasma ion balance, comprising: - a first main channel in fluid communication with the first line portion and having a first passage section, - a second main channel in fluid communication with the second line portion and having a second passage section, - means for the formation of a turbulence area located downstream from and in fluid communication with the first main channel, located upstream from and in fluid communication with the second main channel, these formation means comprising a first fluid passage means defining a reduction in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, - a secondary channel comprising an inlet for letting in a solution reestablishing ion balance and an outlet in fluid communication with at least one of the three elements chosen among the first main channel, the means for the formation of a turbulence area and the second main channel;
A method (400, 500) for autonomous control of electric power consumption by an apparatus, comprising: monitoring (402, 502) electric power measurement data of electric power being generated by a solar array (206a, 206b) of the apparatus, the solar array (206a, 206b) being configured for at least charging a battery and providing electrical power to components of the apparatus; monitoring (404, 504) a state of charge of the battery; autonomously controlling (408, 520) electric power consumption of an integrated payload array of the apparatus (226, 700) in response to at least the state of charge of the battery, the state of charge of the battery being maintained above a preset threshold; and the method (400, 500) characterized in monitoring temperature measurement data of temperature of the integrated payload array; and autonomously controlling electric power consumption of selected components of the integrated payload array in response to the temperature measurement data exceeding a preset temperature operating limit. monitoring (402, 502) electric power measurement data of electric power being generated by a solar array (206a, 206b) of the apparatus, the solar array (206a, 206b) being configured for at least charging a battery and providing electrical power to components of the apparatus; monitoring (404, 504) a state of charge of the battery; autonomously controlling (408, 520) electric power consumption of an integrated payload array of the apparatus (226, 700) in response to at least the state of charge of the battery, the state of charge of the battery being maintained above a preset threshold; and the method (400, 500) characterized in monitoring temperature measurement data of temperature of the integrated payload array; and autonomously controlling electric power consumption of selected components of the integrated payload array in response to the temperature measurement data exceeding a preset temperature operating limit.
An external-injury waterproof protector (1, 2) comprising: a flexible pouch body (10, 30) composed of a waterproofing material and having a mouth at either one end or both ends; and an extensible/contractible annular constriction component (20, 40, 50) hermetically and adhesively attached to either the one end or to both ends of the pouch body (10, 30), the annular constriction component (20, 40, 50) being furnished with a tube portion (21, 41, 51) formed at a narrower diameter than that of the mouth or mouths of the pouch body (10, 30), and constituted so as to enable covering a portion of the four human limbs in a watertight state, characterized in that: the annular constriction component (20, 40, 50) is further furnished with a brim portion (22, 42, 52) formed projecting radially outward from a mouth edge of the tube portion (21, 41, 51); and the brim portion (22, 42, 52) arcuately slopes gently in a flaring form, whereby the mouth (24, 44, 54, 64) of the annular constriction component (20, 40, 50) is furnished with an arcuate sloping surface. a flexible pouch body (10, 30) composed of a waterproofing material and having a mouth at either one end or both ends; and an extensible/contractible annular constriction component (20, 40, 50) hermetically and adhesively attached to either the one end or to both ends of the pouch body (10, 30), the annular constriction component (20, 40, 50) being furnished with a tube portion (21, 41, 51) formed at a narrower diameter than that of the mouth or mouths of the pouch body (10, 30), and constituted so as to enable covering a portion of the four human limbs in a watertight state, characterized in that: the annular constriction component (20, 40, 50) is further furnished with a brim portion (22, 42, 52) formed projecting radially outward from a mouth edge of the tube portion (21, 41, 51); and the brim portion (22, 42, 52) arcuately slopes gently in a flaring form, whereby the mouth (24, 44, 54, 64) of the annular constriction component (20, 40, 50) is furnished with an arcuate sloping surface. the annular constriction component (20, 40, 50) is further furnished with a brim portion (22, 42, 52) formed projecting radially outward from a mouth edge of the tube portion (21, 41, 51); and the brim portion (22, 42, 52) arcuately slopes gently in a flaring form, whereby the mouth (24, 44, 54, 64) of the annular constriction component (20, 40, 50) is furnished with an arcuate sloping surface.
A safened herbicidal composition for use in rice comprising a herbicidally effective amount of (a) a benzyl ester of a compound of the formula and (b) a safener or a compatible herbicide capable of safening.
A patient movement correction method for cone-beam computed tomography comprising: acquiring a set of X-ray projection images of the imaged patient using an X-ray imaging means containing an X-ray source and X-ray detector; defining an initial projection geometry estimate describing the spatial positions and orientation of the X-ray source and the X-ray detector during the acquisition of the X-ray projection images; computing an intermediate CBCT reconstruction using the X-ray projection images and the initial projection geometry estimate; determining projection-image-specific corrective geometric transformations for the initial projection geometry estimate based on the X-ray projection images, the initial projection geometry estimate, and the intermediate CBCT reconstruction; and computing a final CBCT reconstruction using the X-ray projection images and a corrected estimate of the projection geometry corresponding to the determined corrective geometric transformations characterized in that the corrective geometric transformations for the initial projection geometry estimate are determined in a projection-image-specific rotating coordinate system corresponding to the spatial positions and orientations of the X-ray source and X-ray detector during the acquisition of the X-ray projection images. acquiring a set of X-ray projection images of the imaged patient using an X-ray imaging means containing an X-ray source and X-ray detector; defining an initial projection geometry estimate describing the spatial positions and orientation of the X-ray source and the X-ray detector during the acquisition of the X-ray projection images; computing an intermediate CBCT reconstruction using the X-ray projection images and the initial projection geometry estimate; determining projection-image-specific corrective geometric transformations for the initial projection geometry estimate based on the X-ray projection images, the initial projection geometry estimate, and the intermediate CBCT reconstruction; and computing a final CBCT reconstruction using the X-ray projection images and a corrected estimate of the projection geometry corresponding to the determined corrective geometric transformations characterized in that the corrective geometric transformations for the initial projection geometry estimate are determined in a projection-image-specific rotating coordinate system corresponding to the spatial positions and orientations of the X-ray source and X-ray detector during the acquisition of the X-ray projection images.
Method for producing a value and/or security document, wherein the method comprises the following method steps of: a) providing at least one first sheet, at least one second sheet, at least one third sheet, and at least one fourth sheet in roll form, wherein, as the at least one first sheet, the at least one second sheet, and the at least one third sheet, transparent sheets are selected, and as the at least one fourth sheet an opaque sheet is selected, wherein the at least one second sheet is printed with at least one print layer, b) bringing together the at least one first sheet, the at least one second sheet, the at least one third sheet, and the at least one fourth sheet to form a sheet stack, wherein the at least one third sheet is arranged between the at least one second and the at least one fourth sheet, c) laminating the sheet stack by means of pressure and/or heat to form a laminate and d) separating the value and/or security document from the laminate, characterised in that, before the bringing together in method step b), at least one security thread is introduced by means of an adhesive onto the at least one third sheet. a) providing at least one first sheet, at least one second sheet, at least one third sheet, and at least one fourth sheet in roll form, wherein, as the at least one first sheet, the at least one second sheet, and the at least one third sheet, transparent sheets are selected, and as the at least one fourth sheet an opaque sheet is selected, wherein the at least one second sheet is printed with at least one print layer, b) bringing together the at least one first sheet, the at least one second sheet, the at least one third sheet, and the at least one fourth sheet to form a sheet stack, wherein the at least one third sheet is arranged between the at least one second and the at least one fourth sheet, c) laminating the sheet stack by means of pressure and/or heat to form a laminate and d) separating the value and/or security document from the laminate, characterised in that, before the bringing together in method step b), at least one security thread is introduced by means of an adhesive onto the at least one third sheet.
Foldable insert with foldable water reservoir for a flower vase for accommodating flowers and water made of at least one waterproof material, wherein a compressible water reservoir, wherein the insert is supported by the flower vase, wherein the insert comprises two planar surfaces (1a, 1b), the insert is folded along the height of its truncated cone-shape, wherein the folding is such that the insert is folded vertical along the vase's height after introduction into the vase and thus can adapt automatically to the form of the vase by unfolding, and wherein the folding of the insert comprises multiple longitudinal foldings as known from pleated material, wherein a compressible water reservoir is provided on the lower planar surfaces of the insert and connected thereto, wherein the compressible water reservoir comprises a compressible tube, which is in a compressed form if the vase insert filled with water in the flower vase during use and which is decompressed when the insert is taken out from the flower vase due to the water flowing into the tube from the insert.
Medical instruments kit comprising a bistoury, two surgical scissors, six Pean clamps, three Kocher clamps, a metalic bladder probe, two Farabeuf spacing devices, a clamp for anchoring the uterine isthmus and some isthmic and suburethral strips ( B and C), respectively, the clamp consisting of two long rigid arms ( 1 and 2) provided with some posterior portions ( a and b) spaced apart from each other, joined at the lower side by means of a bridge, in front of which the distance between the arms ( 1 and 2) has the maximum value, the latter being non-removably joined together to form an anterior portion ( c), tapered towards an anterior smooth blunt tip ( d), in the immediate proximity thereof, in a proximal curved zone ( g) of the anterior portion ( c) there being cut some upper and lower orifices (e and f), respectively, in front of the bridge the long arms ( 1 and 2) being distally provided with two left side and right side rings ( 4 and 5), respectively, an additional ring being integrally attached to a lower portion ( i) of the right side ring, to the outer side of the long arms ( 1 and 2), in the proximity of the bridge and before the beginning of the anterior portion ( c) there being located two short left side and right side arms ( 7 and 8), respectively, said arms ending with some smooth blunt tips ( g and h).
A wear pad for a telescoping boom assembly comprising: a wear pad body having a first surface and a second surface oppositely positioned from the first surface and spaced from the first surface by a height of the wear pad body; wherein the wear pad is configured to be installed between an inner telescoping boom section and an immediately adjacent outer telescoping boom section, characterised in that the wear pad further comprises: a groove formed in one of the first surface and the second surface, the groove extending along a length of the wear pad body; and an insert positioned in the groove such that a portion of the insert projects outwardly from the groove, wherein the insert is a low friction material or dry or solid lubricant, and wherein the groove and the insert at least partially correspond in shape such that the insert is retained in the groove by way of an interlocking fit. a wear pad body having a first surface and a second surface oppositely positioned from the first surface and spaced from the first surface by a height of the wear pad body; wherein the wear pad is configured to be installed between an inner telescoping boom section and an immediately adjacent outer telescoping boom section, characterised in that the wear pad further comprises: a groove formed in one of the first surface and the second surface, the groove extending along a length of the wear pad body; and an insert positioned in the groove such that a portion of the insert projects outwardly from the groove, wherein the insert is a low friction material or dry or solid lubricant, and wherein the groove and the insert at least partially correspond in shape such that the insert is retained in the groove by way of an interlocking fit. a groove formed in one of the first surface and the second surface, the groove extending along a length of the wear pad body; and an insert positioned in the groove such that a portion of the insert projects outwardly from the groove, wherein the insert is a low friction material or dry or solid lubricant, and wherein the groove and the insert at least partially correspond in shape such that the insert is retained in the groove by way of an interlocking fit.
Human lymphoid precursors cell population isolated from peripheral human blood of a subject affected by a chronical inflammation or autoimmunity state or from the bone marrow of an healthy subject, characterized by the expression on the cell membrane of the surface markers CD34, DNAM-1 expressed in bright mode, and CXCR4.