mhurhangee/ep-ind-claims huggingface dataset:
A method of optimization of a nucleotide coding sequence coding for a predetermined amino acid sequence, whereby the coding sequence is optimized for expression in a predetermined host cell, the method comprising: a) generating at least one original coding sequence that codes for the predetermined amino acid sequence; b) generating at least one newly generated coding sequence from this at least one original coding sequence by replacing in this at least one original coding sequence one or more codons by a synonymous codon; c) determining a fitness value of said at least one original coding sequence and a fitness value of said at least one newly generated coding sequence while using a fitness function that determines at least one of single codon fitness and codon pair fitness for the predetermined host cell; d) choosing one or more selected coding sequence amongst said at least one original coding sequence and said at least one newly generated coding sequence in accordance with a predetermined selection criterion such that the higher is said fitness value, the higher is a chance of being chosen; e) repeating actions b) through d) while treating said one or more selected coding sequence as one or more original coding sequence in actions b) through d) until a predetermined iteration stop criterion is fulfilled wherein said fitness function is defined by means of: fit combi g = fit cp g cpi + fit sc g where fit cp g = 1 g - 1 ⋅ ∑ k = 1 g - 1 w ( c k, c ⁢ k + 1 fit sc g = 1 g ⋅ ∑ k = 1 g r sc target c k - r sc g c k cpi is a real value greater than zero, fit cp ( g) is codon pair fitness function, fit sc ( g) is a single codon fitness function, w (( c ( k), c(k + 1)) is a weight of a codon pair in a coding sequence g, | g | is length of said coding sequence, c ( k) is k-th codon in said sequence of codons, r sc target c k is a desired ratio of codon c ( k) and r sc g c k an actual ratio in the coding sequence g. a) generating at least one original coding sequence that codes for the predetermined amino acid sequence; b) generating at least one newly generated coding sequence from this at least one original coding sequence by replacing in this at least one original coding sequence one or more codons by a synonymous codon; c) determining a fitness value of said at least one original coding sequence and a fitness value of said at least one newly generated coding sequence while using a fitness function that determines at least one of single codon fitness and codon pair fitness for the predetermined host cell; d) choosing one or more selected coding sequence amongst said at least one original coding sequence and said at least one newly generated coding sequence in accordance with a predetermined selection criterion such that the higher is said fitness value, the higher is a chance of being chosen; e) repeating actions b) through d) while treating said one or more selected coding sequence as one or more original coding sequence in actions b) through d) until a predetermined iteration stop criterion is fulfilled
A sensor inserter assembly for applying an on-skin component (134, 134n, 134w,...) to a skin of a host, the sensor inserter assembly comprising: an on-skin component (134, 134n, 134w,...) being movable in at least a distal direction from a proximal position to a distal position, a first securing feature (800, 800y,...) configured to releasably secure the on-skin component (134, 134n, 134w,...) in the proximal position, a second securing feature configured to secure the on-skin component (134, 134n, 134w,...) in the distal position, a pusher configured to move the on-skin component (134, 134n, 134w,...) from the proximal position to the distal position, and a first resistance feature (804, 804y,...) configured to prevent movement of the on-skin component (134, 134n, 134w,...) in a proximal direction at least when the on-skin component (134, 134n, 134w,...) is in the distal position, wherein the first resistance feature (804, 804y,...) comprises a distally-facing surface of the pusher. an on-skin component (134, 134n, 134w,...) being movable in at least a distal direction from a proximal position to a distal position, a first securing feature (800, 800y,...) configured to releasably secure the on-skin component (134, 134n, 134w,...) in the proximal position, a second securing feature configured to secure the on-skin component (134, 134n, 134w,...) in the distal position, a pusher configured to move the on-skin component (134, 134n, 134w,...) from the proximal position to the distal position, and a first resistance feature (804, 804y,...) configured to prevent movement of the on-skin component (134, 134n, 134w,...) in a proximal direction at least when the on-skin component (134, 134n, 134w,...) is in the distal position, wherein the first resistance feature (804, 804y,...) comprises a distally-facing surface of the pusher.
A detent assembly for a mobility aid, in particular for a holm of a mobility aid, which holm is adjustable in height, comprising two parts that can be moved with respect to each other, wherein the first part comprises a detent rail and the second part comprises a detent means for establishing a contact with the detent rail, and wherein an operating element is provided for locking the detent means in contact with the detent rail, wherein the detent assembly includes a rocker mounted in a pivoting manner, characterized in that the detent means is driven by the rocker mounted in a pivoting manner, wherein the rocker can be fixed by means of the operating element in a configuration which locks the detent means in contact with the detent rail, wherein a second detent means for establishing an additional contact with the detent rail is arranged on the rocker, wherein the second detent means is out of contact with the detent rail in an adjustment configuration and is in contact with the detent rail in the locking configuration.
A combustor, comprising: a. an end cap that extends radially across at least a portion of the combustor, wherein the end cap comprises an upstream surface axially separated from a downstream surface; b. a combustion chamber downstream of the end cap; c. a plurality of premixer tubes that extend from a premixer tube inlet proximate to the upstream surface through the downstream surface of the end cap, wherein each premixer tube provides fluid communication through the end cap to the combustion chamber; d. means for conditioning flow through the plurality of premixer tubes characterized in that the means comprises one or more slots in one or more premixer tube inlets. a. an end cap that extends radially across at least a portion of the combustor, wherein the end cap comprises an upstream surface axially separated from a downstream surface; b. a combustion chamber downstream of the end cap; c. a plurality of premixer tubes that extend from a premixer tube inlet proximate to the upstream surface through the downstream surface of the end cap, wherein each premixer tube provides fluid communication through the end cap to the combustion chamber; d. means for conditioning flow through the plurality of premixer tubes characterized in that the means comprises one or more slots in one or more premixer tube inlets.
A peptide consisting of the following amino acid sequence of Seq Id No 21 IVRYTKKVPQVS and its amidated, acetylated, sulfated, phosphorylated and/or glycosylated derivatives.
Use of a white-smoke reduction component selected from among manganese oxide and silver oxide for preventing white smoke from being emitted from a diesel engine, wherein said white-smoke reduction component is included in a diesel particulate filter composition which is applied to a diesel particulate filter of a smoke reduction apparatus, and wherein said smoke reduction apparatus includes a diesel oxidation catalyst and said DPF mounted at a rear end of the diesel engine, wherein a composition applied to the diesel oxidation catalyst includes Pt-Pd/Al 2 O 3 and zeolite.
An electrically heated catalytic converter for purifying exhaust gas, the electrically heated catalytic converter comprising: a catalyst carrier supporting a catalyst and configured to generate heat by energization; a case for accommodating the catalyst carrier; and an electrical insulation mat interposed between the catalyst carrier and the case, wherein the case comprises an outer tube disposed at the outermost side and an inner tube disposed inside the outer tube; in a cross section upstream of the catalyst carrier taken along a plane including the central axis of the case, the inner tube is curved at least once so as to outwardly project and then obliquely extends toward the central axis of the case, characterized in that an insulation layer having a thickness of 100 to 200 μm is formed in the range from an end portion of the inner tube to 10% of the length of the inner tube from the end portion of the inner tube to an end of the catalyst carrier, an insulation layer having a thickness of 100 to 400 μm is formed in the range from a point immediately after 10% of the length away from the end portion of the inner tube to 50% of the length of the inner tube from the end portion of the inner tube to the end of the catalyst carrier, and the insulation layer formed in the range from the end portion of the inner tube to 10% of the length is thinner than the insulation layer formed in the range from a point immediately after 10% of the length away from the end portion of the inner tube to 50% of the length. a catalyst carrier supporting a catalyst and configured to generate heat by energization; a case for accommodating the catalyst carrier; and an electrical insulation mat interposed between the catalyst carrier and the case, wherein the case comprises an outer tube disposed at the outermost side and an inner tube disposed inside the outer tube; in a cross section upstream of the catalyst carrier taken along a plane including the central axis of the case, the inner tube is curved at least once so as to outwardly project and then obliquely extends toward the central axis of the case, characterized in that
Dry-running protection device for a slide ring seal of a pump system, comprising an electric drive motor and a common shaft for both the motor and the pump, which shaft is enclosed by the slide ring seal, to which are connected a fluid detector and a solenoid valve, which comprises a separating diaphragm and a ventilation apparatus arranged above said separating diaphragm, the fluid detector being arranged at a predeterminable distance (a) above the minimum level of the pump on or in a pipe fitting which is attached to the pump housing at the same height as the slide ring seal and is connected to the solenoid valve in terms of flow, characterised in that an electronics unit which is spatially separate from the pipe fitting comprises a control and evaluation apparatus which is supplied by the fluid detector, the response time or switching status time of the electronics unit being preselectable by means of an actuator.
A refrigerator comprising: a refrigerating chamber and a freezing chamber; a partition wall provided between the refrigerating chamber and the freezing chamber; an evaporator case (210, 270) arranged in the freezing chamber and located at the partition wall; an evaporator arranged in the evaporator case (210, 270) and having a first heat exchanger and a second heat exchanger inclined towards each other and with respect to the partition wall, wherein the refrigerator further comprises a defrosting water tray provided below the evaporator to collect defrosting water, the defrosting water tray including a first inclined surface inclined corresponding to the first heat exchanger, a second inclined surface inclined corresponding to the second heat exchanger, and a recess defining a central portion of the defrosting water tray and formed between the first inclined surface and the second inclined surface, the first heat exchanger is arranged on the first inclined surface of the defrosting water tray and the second heat exchanger is arranged on the second inclined surface of the defrosting water tray, a central portion of the evaporator includes a fan suction passage, the first heat exchanger and the second heat exchanger are inclined upward toward lateral sides thereof with respect to the fan suction passage, and the fan suction passage is formed between the first and second heat exchangers (220a, 220b) and above the recess. a refrigerating chamber and a freezing chamber; a partition wall provided between the refrigerating chamber and the freezing chamber; an evaporator case (210, 270) arranged in the freezing chamber and located at the partition wall; an evaporator arranged in the evaporator case (210, 270) and having a first heat exchanger and a second heat exchanger inclined towards each other and with respect to the partition wall, wherein the refrigerator further comprises a defrosting water tray provided below the evaporator to collect defrosting water, the defrosting water tray including a first inclined surface inclined corresponding to the first heat exchanger, a second inclined surface inclined corresponding to the second heat exchanger, and a recess defining a central portion of the defrosting water tray and formed between the first inclined surface and the second inclined surface, the first heat exchanger is arranged on the first inclined surface of the defrosting water tray and the second heat exchanger is arranged on the second inclined surface of the defrosting water tray, a central portion of the evaporator includes a fan suction passage, the first heat exchanger and the second heat exchanger are inclined upward toward lateral sides thereof with respect to the fan suction passage, and the fan suction passage is formed between the first and second heat exchangers (220a, 220b) and above the recess.
A tethered optical imaging probe, comprising: a motor; a reflective surface rotatably coupled to the motor; a capsule enclosing the motor and the reflective surface, wherein the capsule is dimensioned to be swallowable by a patient; and a tether coupled to a first end of the capsule, the tether including an optical waveguide arranged therein, wherein the optical waveguide is configured to receive source light at a distal end of the optical waveguide and configured to project the source light from a proximal end of the optical waveguide onto the reflective surface and configured to receive reflected light from the reflective surface at the proximal end of the optical waveguide and configured to transmit the reflected light to the distal end of the optical waveguide, wherein the motor, the reflective surface, and the optical waveguide are positioned to define a circumferential optical path for the reflected source light that encompasses a portion of the capsule, characterized in that a detection object in the form of a light emitting material is arranged on the portion of the capsule in the circumferential optical path. a motor; a reflective surface rotatably coupled to the motor; a capsule enclosing the motor and the reflective surface, wherein the capsule is dimensioned to be swallowable by a patient; and a tether coupled to a first end of the capsule, the tether including an optical waveguide arranged therein, wherein the optical waveguide is configured to receive source light at a distal end of the optical waveguide and configured to project the source light from a proximal end of the optical waveguide onto the reflective surface and configured to receive reflected light from the reflective surface at the proximal end of the optical waveguide and configured to transmit the reflected light to the distal end of the optical waveguide, wherein the motor, the reflective surface, and the optical waveguide are positioned to define a circumferential optical path for the reflected source light that encompasses a portion of the capsule, characterized in that a detection object in the form of a light emitting material is arranged on the portion of the capsule in the circumferential optical path.
A pyrotechnic initiator for initiating an ignition tube by means of electrical triggering, comprising a sleeve that is open on one side and has an ignition pill that is located therein and is made of a glow wire and at least one pyrotechnic set surrounding the glow wire for generating a shock pulse initiating the end of the ignition tube, wherein the ignition tube can be coupled to the sleeve, which is open at one end, and an explosive present in the ignition tube can be initiated by the shock pulse, characterized in that a splinter guard is provided for the sleeve, which is open on one side, for surrounding the sleeve, wherein a tearing open of the sleeve during the generation of the shock pulse can be contained by the splinter guard and the release of splinters into the environment can be prevented, wherein an adapter is provided for the centered insertion of the ignition tube into the sleeve, wherein the end of the ignition tube can be positioned directly in contact with the ignition pill, wherein the adapter, the ignition tube and the sleeve form an assembly which can be firmly fixed and/or sealed with respect to each other by means of a pliers tool. a sleeve that is open on one side and has an ignition pill that is located therein and is made of a glow wire and at least one pyrotechnic set surrounding the glow wire for generating a shock pulse initiating the end of the ignition tube, wherein the ignition tube can be coupled to the sleeve, which is open at one end, and an explosive present in the ignition tube can be initiated by the shock pulse, characterized in that a splinter guard is provided for the sleeve, which is open on one side, for surrounding the sleeve, wherein a tearing open of the sleeve during the generation of the shock pulse can be contained by the splinter guard and the release of splinters into the environment can be prevented, wherein an adapter is provided for the centered insertion of the ignition tube into the sleeve, wherein the end of the ignition tube can be positioned directly in contact with the ignition pill, wherein the adapter, the ignition tube and the sleeve form an assembly which can be firmly fixed and/or sealed with respect to each other by means of a pliers tool.
A method for providing video telephony using a television apparatus, the method comprising: receiving by the television apparatus a command from a user of the television apparatus to perform video telephony with an external television apparatus; determining by the television apparatus a state of the external television apparatus; characterized by transmitting, by the television apparatus, without further command from the user of the television apparatus, a short message service message to a mobile phone of a user of the external television apparatus, if the external television apparatus is switched off, wherein the SMS message indicates there is a call request to the external TV apparatus. receiving by the television apparatus a command from a user of the television apparatus to perform video telephony with an external television apparatus; determining by the television apparatus a state of the external television apparatus; characterized by transmitting, by the television apparatus, without further command from the user of the television apparatus, a short message service message to a mobile phone of a user of the external television apparatus, if the external television apparatus is switched off, wherein the SMS message indicates there is a call request to the external TV apparatus.
A preparation comprising a liquid, gel, or semisolid, and a pharmaceutical agent for use in modulating local tissue physiology of tissue surrounding the nerves that are the target of denervation, wherein the preparation is delivered into said tissue and the preparation modulates local tonicity or osmolarity of the tissue to achieve enhanced cellular uptake of the pharmaceutical agent by said tissue, wherein the liquid, gel, or semisolid comprises ethanol and the pharmaceutical agent comprises guanethidine monosulfate.
Apparatus for gliding over a body of flowing water, in particular for surfing, water skiing, kiteboarding and/or wakeboarding, comprising a first buoyancy body, characterized by a second buoyancy body which is designed to be connected to the first buoyancy body by means of a cable, and a pulley mechanism which is designed such that the cable passes therethrough and which is designed to be connected to a first stationary object, such that the first buoyancy body and the second buoyancy body can move over the body of flowing water in substantially opposing directions with respect to one another by means of the pulley mechanism through which the cable passes.
A method comprising: determining that an adjacent cell is a private cell; and sending, from a user equipment to a serving network node of the user equipment, a measurement report of the private cell that includes an identifier for the private cell, characterized in that the measurement report comprises a one-bit indicator indicating whether the user equipment is a member of a closed subscriber group that has access rights to the private cell. determining that an adjacent cell is a private cell; and sending, from a user equipment to a serving network node of the user equipment, a measurement report of the private cell that includes an identifier for the private cell, characterized in that the measurement report comprises a one-bit indicator indicating whether the user equipment is a member of a closed subscriber group that has access rights to the private cell.
A method of loading a plant picornavirus, comprising contacting a plant picornavirus including a nucleic acid in solution with a molar excess of at least 500 fold of a cargo molecule that has a molecular weight from 100 to 5000 daltons and has an affinity for nucleic acid to non-covalently load the icosahedral capsule of the plant picornavirus with the cargo molecule, wherein the cargo molecule having an affinity for nucleic acid is loaded using diffusion, and purifying the loaded plant picornavirus.
A device for analyzing biological cells, the device comprising: a first platter for positioning a first group of biological cells; a first head positioned adjacently to the first platter for providing first electromagnetic radiation to at least a first subset of the first group of biological cells; and a first electrode positioned adjacently to the first platter for detecting the first electromagnetic radiation having interacted with the first subset of the first group of biological cells for determining impedance values for the first subset of the first group of biological cells, characterized in that the first head is located above the first platter and the first electrode is located under the first platter, or vice versa, with the lateral locations of the first head and the first electrode corresponding to each other. a first platter for positioning a first group of biological cells; a first head positioned adjacently to the first platter for providing first electromagnetic radiation to at least a first subset of the first group of biological cells; and a first electrode positioned adjacently to the first platter for detecting the first electromagnetic radiation having interacted with the first subset of the first group of biological cells for determining impedance values for the first subset of the first group of biological cells, characterized in that the first head is located above the first platter and the first electrode is located under the first platter, or vice versa, with the lateral locations of the first head and the first electrode corresponding to each other.