A compound of formula I: wherein Y = O, or S, R 1 = selected from following groups: wherein X = CH 2, NH, S, or O, R 8 = -H, -NH 2, -OH, -N(R 4, R 5), -C(R 4 R 5) 1-7 NR 6 R 7, -C(R 4 R 5) 1-7 OR 6, or -N(R 4)NR 5 R 6, wherein R 4, R 5, R 6, R 7 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, and N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 9,R 10,R 11,R 12, and R 13 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S or N; aryls (either unsubstituted and substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 2, is selected from a group consisting of H, OH, NH 2, OR 14, NR 14 R 15, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, wherein R 14,R 15 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), and R 3 is selected from a group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl. Y = O, or S, R 1 = selected from following groups: wherein X = CH 2, NH, S, or O, R 8 = -H, -NH 2, -OH, -N(R 4, R 5), -C(R 4 R 5) 1-7 NR 6 R 7, -C(R 4 R 5) 1-7 OR 6, or -N(R 4)NR 5 R 6, wherein R 4, R 5, R 6, R 7 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, and N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 9,R 10,R 11,R 12, and R 13 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S or N; aryls (either unsubstituted and substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 2, is selected from a group consisting of H, OH, NH 2, OR 14, NR 14 R 15, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, wherein R 14,R 15 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), and R 3 is selected from a group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl. wherein X = CH 2, NH, S, or O, R 8 = -H, -NH 2, -OH, -N(R 4, R 5), -C(R 4 R 5) 1-7 NR 6 R 7, -C(R 4 R 5) 1-7 OR 6, or -N(R 4)NR 5 R 6, wherein R 4, R 5, R 6, R 7 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, and N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 9,R 10,R 11,R 12, and R 13 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S or N; aryls (either unsubstituted and substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), R 2, is selected from a group consisting of H, OH, NH 2, OR 14, NR 14 R 15, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, wherein R 14,R 15 = H, alkyls (C 1 -C 6), cycloalkyls (C 3 -C 8) with or without nuclear heteroatoms such as O, S, N, aryls (either unsubstituted or substituted aromatics), or heteroaromatics (either unsubstituted or substituted heteroaromatics), and R 3 is selected from a group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl.