A drug delivery device (100, 400, 500, 600, 650), comprising: a housing (102, 402, 504, 602), wherein said housing defines an opening and a chamber for a drug cartridge (524, 614); a door (404, 424, 434, 502, 522, 604) connected to said housing (102, 402, 504, 602), said door (404, 424, 434, 502, 522, 604) having a range of movement between a fully open position and a closed position, wherein said door (404, 424, 434, 502, 522, 604) blocks access to said opening when said door (404, 424, 434, 502, 522, 604) is in said closed position; characterized in that: said door (404, 424, 434, 502, 522, 604) further comprises a transmission to couple between a motor of said drug delivery device (100, 400, 500, 600, 650) and said drug cartridge (524, 614) when said door (404, 424, 434, 502, 522, 604) is in said closed position; said drug delivery device (100, 400, 500, 600, 650) further comprises: a biasing element (406, 506, 612) connected to said housing (102, 402, 504, 602) or said door (404, 424, 434, 502, 522, 604), wherein said biasing element (406, 506, 612) is positioned to interfere with the movement of said door (404, 424, 434, 502, 522, 604) by applying an opening force to open said door when said range of movement of said door is near said closed position, thus defining an exclusion zone; wherein said biasing element (406, 506, 612) applies said opening force in the last 30 degrees of rotation of said door (404, 424, 434, 502, 522, 604) toward closure or when during the rotation of said door (404, 424, 434, 502, 522, 604) said door reaches the last 30% of said range of movement; and a locking mechanism (616, 618) between said door (404, 424, 434, 502, 522, 604) and said housing (102, 402, 504, 602), said locking mechanism (616, 618) applies a locking force on said door (404, 424, 434, 502, 522, 604) greater and in an opposite direction to the opening force applied by said biasing element (406, 506, 612). a housing (102, 402, 504, 602), wherein said housing defines an opening and a chamber for a drug cartridge (524, 614); a door (404, 424, 434, 502, 522, 604) connected to said housing (102, 402, 504, 602), said door (404, 424, 434, 502, 522, 604) having a range of movement between a fully open position and a closed position, wherein said door (404, 424, 434, 502, 522, 604) blocks access to said opening when said door (404, 424, 434, 502, 522, 604) is in said closed position; characterized in that: said door (404, 424, 434, 502, 522, 604) further comprises a transmission to couple between a motor of said drug delivery device (100, 400, 500, 600, 650) and said drug cartridge (524, 614) when said door (404, 424, 434, 502, 522, 604) is in said closed position; said drug delivery device (100, 400, 500, 600, 650) further comprises: a biasing element (406, 506, 612) connected to said housing (102, 402, 504, 602) or said door (404, 424, 434, 502, 522, 604), wherein said biasing element (406, 506, 612) is positioned to interfere with the movement of said door (404, 424, 434, 502, 522, 604) by applying an opening force to open said door when said range of movement of said door is near said closed position, thus defining an exclusion zone; wherein said biasing element (406, 506, 612) applies said opening force in the last 30 degrees of rotation of said door (404, 424, 434, 502, 522, 604) toward closure or when during the rotation of said door (404, 424, 434, 502, 522, 604) said door reaches the last 30% of said range of movement; and a locking mechanism (616, 618) between said door (404, 424, 434, 502, 522, 604) and said housing (102, 402, 504, 602), said locking mechanism (616, 618) applies a locking force on said door (404, 424, 434, 502, 522, 604) greater and in an opposite direction to the opening force applied by said biasing element (406, 506, 612). said door (404, 424, 434, 502, 522, 604) further comprises a transmission to couple between a motor of said drug delivery device (100, 400, 500, 600, 650) and said drug cartridge (524, 614) when said door (404, 424, 434, 502, 522, 604) is in said closed position; said drug delivery device (100, 400, 500, 600, 650) further comprises: a biasing element (406, 506, 612) connected to said housing (102, 402, 504, 602) or said door (404, 424, 434, 502, 522, 604), wherein said biasing element (406, 506, 612) is positioned to interfere with the movement of said door (404, 424, 434, 502, 522, 604) by applying an opening force to open said door when said range of movement of said door is near said closed position, thus defining an exclusion zone; wherein said biasing element (406, 506, 612) applies said opening force in the last 30 degrees of rotation of said door (404, 424, 434, 502, 522, 604) toward closure or when during the rotation of said door (404, 424, 434, 502, 522, 604) said door reaches the last 30% of said range of movement; and a locking mechanism (616, 618) between said door (404, 424, 434, 502, 522, 604) and said housing (102, 402, 504, 602), said locking mechanism (616, 618) applies a locking force on said door (404, 424, 434, 502, 522, 604) greater and in an opposite direction to the opening force applied by said biasing element (406, 506, 612).