A process for identifying an antagonist of hTAS2R14 bitter taste receptor activity, wherein the hTAS2R14 bitter taste receptor is encoded by a polynucleotide selected from the group consisting of: (a) polynucleotide encoding at least the mature form of the polypeptide having the deduced amino acid sequence as shown in SEQ ID NO: 1 (b) polynucleotide having the coding sequence, as shown in SEQ ID NO: 2 encoding at least the mature form of the polypeptide; (c) polynucleotides encoding a fragment or derivative of a polypeptide encoded by a polynucleotide of any one of (a) to (b), wherein in said derivative one to 50 amino acid residues are conservatively substituted compared to said polypeptide, and said fragment or derivative has hTAS2R14 bitter taste receptor activity; (d) polynucleotides which are at least 50% identical to a polynucleotide as defined in any one of (a) to (c) and which code for a polypeptide having hTAS2R14 bitter taste receptor activity; and (e) polynucleotides the complementary strand of which hybridizes, preferably under stringent conditions to a polynucleotide as defined in any one of (a) to (d) and which code for a polypeptide having hTAS2R14 bitter taste receptor activity; comprising: contacting a host cell genetically engineered with said polynucleotide with a potential antagonist; and determining whether the potential antagonist antagonizes the bitter taste receptor activity of said polypeptide wherein prior, concomitantly and/or after step said host cell is contacted with an agonist selected from the group consisting of 1,8-naphthaldehydic acid, 1-naphthoic acid, 1-nitronaphthalene, picrotin, picrotoxinin, piperonylic acid, sodium benzoate, (-)-α-thujone, parthenolide, herbolide A, herbolide D acetate, hydroxy-8α-parthenolide, pseudo-artabsine, and functional derivates thereof and wherein an antagonist lowers the hTAS2R14 bitter taste receptor activity elicited by one of said agonists by at least 10%. (a) polynucleotide encoding at least the mature form of the polypeptide having the deduced amino acid sequence as shown in SEQ ID NO: 1 (b) polynucleotide having the coding sequence, as shown in SEQ ID NO: 2 encoding at least the mature form of the polypeptide; (c) polynucleotides encoding a fragment or derivative of a polypeptide encoded by a polynucleotide of any one of (a) to (b), wherein in said derivative one to 50 amino acid residues are conservatively substituted compared to said polypeptide, and said fragment or derivative has hTAS2R14 bitter taste receptor activity; (d) polynucleotides which are at least 50% identical to a polynucleotide as defined in any one of (a) to (c) and which code for a polypeptide having hTAS2R14 bitter taste receptor activity; and (e) polynucleotides the complementary strand of which hybridizes, preferably under stringent conditions to a polynucleotide as defined in any one of (a) to (d) and which code for a polypeptide having hTAS2R14 bitter taste receptor activity; comprising: contacting a host cell genetically engineered with said polynucleotide with a potential antagonist; and determining whether the potential antagonist antagonizes the bitter taste receptor activity of said polypeptide wherein prior, concomitantly and/or after step said host cell is contacted with an agonist selected from the group consisting of 1,8-naphthaldehydic acid, 1-naphthoic acid, 1-nitronaphthalene, picrotin, picrotoxinin, piperonylic acid, sodium benzoate, (-)-α-thujone, parthenolide, herbolide A, herbolide D acetate, hydroxy-8α-parthenolide, pseudo-artabsine, and functional derivates thereof and wherein an antagonist lowers the hTAS2R14 bitter taste receptor activity elicited by one of said agonists by at least 10%. contacting a host cell genetically engineered with said polynucleotide with a potential antagonist; and determining whether the potential antagonist antagonizes the bitter taste receptor activity of said polypeptide