Micelle comprising a triblock copolymer, wherein said triblock copolymer is of formula VII: x 1 is 1-20; x 2 is 0-20; M is a metal ion; n is 20 to 500; m is 0, 1, or 2; y is 5 to 100; R y is selected from one or more natural or unnatural amino acid side chain groups such that the overall block is hydrophobic; and each R T is independently selected from either -J-T or -Z(CH 2 CH 2 Y) p (CH 2) t R 3, wherein: Z is -O-, -S-, -C≡C-, or -CH 2 -; each Y is independently -O- or -S-; p is 0-10; t is 0-10; and R 3 is -N 3, -CN, a mono-protected amine, a di-protected amine, a protected aldehyde, a protected hydroxyl, a protected carboxylic acid, a protected thiol, a 9-30 membered crown ether, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety; J is independently a valence bond or a bivalent, saturated or unsaturated, straight or branched C 1-12 hydrocarbon chain; each T is independently a targeting group. wherein at least one therapeutic agent is situated within the core of said micelle, wherein said therapeutic agent is selected from the group comprising: taxane, paclitaxel, docetaxel, cabazitaxel, epothilone, in particular Epothilone B, Epothilone D, Epothilone A, Epothilone C, a vinca alkaloid, vinorelbine, berberine, berberrubine, acamptothecin, SN-38, S39625, anthracycline, daunorubicin, doxorubicin, aminopterin, picoplatin, or a platinum therapeutic, or combinations thereof. x 1 is 1-20; x 2 is 0-20; M is a metal ion; n is 20 to 500; m is 0, 1, or 2; y is 5 to 100; R y is selected from one or more natural or unnatural amino acid side chain groups such that the overall block is hydrophobic; and each R T is independently selected from either -J-T or -Z(CH 2 CH 2 Y) p (CH 2) t R 3, wherein: Z is -O-, -S-, -C≡C-, or -CH 2 -; each Y is independently -O- or -S-; p is 0-10; t is 0-10; and R 3 is -N 3, -CN, a mono-protected amine, a di-protected amine, a protected aldehyde, a protected hydroxyl, a protected carboxylic acid, a protected thiol, a 9-30 membered crown ether, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety; J is independently a valence bond or a bivalent, saturated or unsaturated, straight or branched C 1-12 hydrocarbon chain; each T is independently a targeting group. Z is -O-, -S-, -C≡C-, or -CH 2 -; each Y is independently -O- or -S-; p is 0-10; t is 0-10; and R 3 is -N 3, -CN, a mono-protected amine, a di-protected amine, a protected aldehyde, a protected hydroxyl, a protected carboxylic acid, a protected thiol, a 9-30 membered crown ether, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a detectable moiety; J is independently a valence bond or a bivalent, saturated or unsaturated, straight or branched C 1-12 hydrocarbon chain; each T is independently a targeting group.