A composition for parenteral or enteral administration comprising a galactoarabino-rhamnogalacturonate in a pharmaceutical acceptable carrier, wherein the galacto-rhamnogalacturonate is a galactoarabino-rhamnogalacturonate, comprising a 1,4-linked galacturonic acid (GalA) and methyl galacturonate (MeGalA) residues backbone linked to branched heteropolymers of alternating oligomers of α-1,2 linked rhamnose and α-1,4-linked GalA residues, the rhamnose residues carrying a primary branching of oligomers of 1,4-β-D-galactose residues, 1,5-α-L-arabinose residues, or combinations thereof, wherein the molar percent of the 1,4-β-D-Gal, 1,5-α-L-Ara residues and combination thereof is at least 8 % of the total molar carbohydrates, wherein the 1,4-β-D-Gal and 1,5-α-L-Ara residues are present at a ratio ranging from 1:1 to 3:1, wherein the galactoarabino-rhamnogalacturonate has a degree of methoxylation ranging from 40% to 70%, for use in a method comprising administering to a subject in need thereof an effective dose of the composition that results in at least one of the following: at least a 10% reduction in proteinuria or at least a 10% reduction in the rate of increase of proteinuria; at least a 10% increase in glomerular filtration rate or at least a 10% reduction in the rate of decline of glomerular filtration rate; at least a 10% reduction of mesangial extracellular matrix or at least a 10% reduction in the rate of increase of mesangial extracellular matrix; at least a 5% reduction in the glomerular capillary basement membrane thickness; at least a 10% reduction in the fractional volume of the mesangium or at least a 10% reduction in the rate of increase of the fractional volume of the mesangium; at least a 10% reduction in the interstitial tubular volume or at least a 10% reduction in the rate of increase in the interstitial volume; at least a 10% reduction in the amount of collagen in the interstitial tubular space or at least a 10% reduction in the rate of increase of the collagen in the interstitial tubular space; at least 10% change in the level of the serum biomarkers of diabetic nephropathy; wherein the subject in need thereof has at least one of the following: a primary glomerulopathic disease, a secondary glomerulopathic disease, and renal tubule-interstitial disorder. at least a 10% reduction in proteinuria or at least a 10% reduction in the rate of increase of proteinuria; at least a 10% increase in glomerular filtration rate or at least a 10% reduction in the rate of decline of glomerular filtration rate; at least a 10% reduction of mesangial extracellular matrix or at least a 10% reduction in the rate of increase of mesangial extracellular matrix; at least a 5% reduction in the glomerular capillary basement membrane thickness; at least a 10% reduction in the fractional volume of the mesangium or at least a 10% reduction in the rate of increase of the fractional volume of the mesangium; at least a 10% reduction in the interstitial tubular volume or at least a 10% reduction in the rate of increase in the interstitial volume; at least a 10% reduction in the amount of collagen in the interstitial tubular space or at least a 10% reduction in the rate of increase of the collagen in the interstitial tubular space; at least 10% change in the level of the serum biomarkers of diabetic nephropathy; wherein the subject in need thereof has at least one of the following: a primary glomerulopathic disease, a secondary glomerulopathic disease, and renal tubule-interstitial disorder.