A system for acquiring image data of a subject with an imaging system, comprising: a gantry configured to completely annularly encompass at least a portion of the subject, the subject positioned along at an isocenter of the imaging system; a source positioned within and movable relative to the gantry, the source responsive to a signal to output at least one pulse; a detector positioned within and movable relative to the gantry and the source to detect the at least one pulse emitted by the source; a detector control module configured to set detector data based on the detected at least one pulse; a rotor positioned within the gantry and movable within the gantry, the source and the detector coupled to the rotor so as to be substantially opposed from each other, the source and the detector movable relative to the rotor; at least one input device to allow a user to input a region to be imaged based on a selection of at least a location in a first image data acquired with the imaging system, wherein the region to be imaged relates to a portion of the subject off the isocenter of the imaging system; an image control module configured to receive the user input from the at least one user input device and to set the signal for the source and to receive the detector data, the image control module operable to reconstruct image data based on the detector data; and a move control module configured to set move data based on a signal from the image control module for each of the source, detector, and rotor that causes the source, detector, and rotor to move independently in a desired motion profile to acquire the image data of said portion of the subject off the isocenter of the imaging system. a gantry configured to completely annularly encompass at least a portion of the subject, the subject positioned along at an isocenter of the imaging system; a source positioned within and movable relative to the gantry, the source responsive to a signal to output at least one pulse; a detector positioned within and movable relative to the gantry and the source to detect the at least one pulse emitted by the source; a detector control module configured to set detector data based on the detected at least one pulse; a rotor positioned within the gantry and movable within the gantry, the source and the detector coupled to the rotor so as to be substantially opposed from each other, the source and the detector movable relative to the rotor; at least one input device to allow a user to input a region to be imaged based on a selection of at least a location in a first image data acquired with the imaging system, wherein the region to be imaged relates to a portion of the subject off the isocenter of the imaging system; an image control module configured to receive the user input from the at least one user input device and to set the signal for the source and to receive the detector data, the image control module operable to reconstruct image data based on the detector data; and a move control module configured to set move data based on a signal from the image control module for each of the source, detector, and rotor that causes the source, detector, and rotor to move independently in a desired motion profile to acquire the image data of said portion of the subject off the isocenter of the imaging system.