Power supply system comprising: - a power supply circuit having a terminal (HV+) having a voltage level (ΔHV); - a current sensor adapted to generate a current measurement signal (S1_ms) representative of the measurement of the current (I_HV+) flowing through the terminal of the power supply circuit; - a protection circuit comprising: • an input terminal (l1_IN) adapted to receive the current measurement signal (S1_ms) representative of the measurement of the current flowing through said terminal of the power supply circuit; characterized in that the protection circuit further comprises: • a differentiator (2-1; 2-2, 2-3) adapted to measure the slope of the current measurement signal; • a driving stage (2-10, 2-12, 2-11, 2-20, 2-21, 2-22, 2-23, 2-30, 2-24, 2-25, 2-26, 2-31, 2-32, 2-35) interposed between the differentiator and the output terminal of the protection circuit, the driving stage being adapted to generate a disconnection signal (S1_dsn) carrying: ▪ a first value representative of the electrical connection of the internal components of the power supply circuit to its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is less than or equal to a threshold value; or ▪ a second value representative of the electrical disconnection of the internal components of the power supply circuit from its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is greater than the threshold value; • an output terminal (I1_O) adapted to generate the disconnection signal (S1_dsn); wherein the power supply circuit is configured to receive the disconnection signal (S1_dsn) and, alternatively, to electrically connect the internal components thereof to its terminal or electrically disconnect the internal components thereof from its terminal, as a function of the value of the disconnection signal (S1_dsn). - a power supply circuit having a terminal (HV+) having a voltage level (ΔHV); - a current sensor adapted to generate a current measurement signal (S1_ms) representative of the measurement of the current (I_HV+) flowing through the terminal of the power supply circuit; - a protection circuit comprising: • an input terminal (l1_IN) adapted to receive the current measurement signal (S1_ms) representative of the measurement of the current flowing through said terminal of the power supply circuit; characterized in that the protection circuit further comprises: • a differentiator (2-1; 2-2, 2-3) adapted to measure the slope of the current measurement signal; • a driving stage (2-10, 2-12, 2-11, 2-20, 2-21, 2-22, 2-23, 2-30, 2-24, 2-25, 2-26, 2-31, 2-32, 2-35) interposed between the differentiator and the output terminal of the protection circuit, the driving stage being adapted to generate a disconnection signal (S1_dsn) carrying: ▪ a first value representative of the electrical connection of the internal components of the power supply circuit to its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is less than or equal to a threshold value; or ▪ a second value representative of the electrical disconnection of the internal components of the power supply circuit from its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is greater than the threshold value; • an output terminal (I1_O) adapted to generate the disconnection signal (S1_dsn); • an input terminal (l1_IN) adapted to receive the current measurement signal (S1_ms) representative of the measurement of the current flowing through said terminal of the power supply circuit; characterized in that the protection circuit further comprises: • a differentiator (2-1; 2-2, 2-3) adapted to measure the slope of the current measurement signal; • a driving stage (2-10, 2-12, 2-11, 2-20, 2-21, 2-22, 2-23, 2-30, 2-24, 2-25, 2-26, 2-31, 2-32, 2-35) interposed between the differentiator and the output terminal of the protection circuit, the driving stage being adapted to generate a disconnection signal (S1_dsn) carrying: ▪ a first value representative of the electrical connection of the internal components of the power supply circuit to its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is less than or equal to a threshold value; or ▪ a second value representative of the electrical disconnection of the internal components of the power supply circuit from its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is greater than the threshold value; ▪ a first value representative of the electrical connection of the internal components of the power supply circuit to its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is less than or equal to a threshold value; or ▪ a second value representative of the electrical disconnection of the internal components of the power supply circuit from its terminal (HV+), in case the measured value of the slope of the current signal flowing through said terminal of the power supply circuit is greater than the threshold value; • an output terminal (I1_O) adapted to generate the disconnection signal (S1_dsn);