mhurhangee/ep-ind-claims huggingface dataset:
An IL-17 binding antibody or fragment thereof comprising both heavy (V H) and light chain (V L) variable domains for use in the treatment of an inflammatory arthritis, wherein said IL-17 binding antibody or fragment thereof comprises at least one antigen binding site comprising: (a) a V H which comprises in sequence hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence SEQ ID NO:1, said CDR2 having the amino acid sequence SEQ ID NO:2, and said CDR3 having the amino acid sequence SEQ ID NO:3, wherein the hypervariable regions are according to the Kabat definition; or (b) a V H which comprises in sequence hypervariable regions CDR1-x, CDR2-x and CDR3-x, said CDR1-x having the amino acid sequence SEQ ID NO:11, said CDR2-x having the amino acid sequence SEQ ID NO:12, and said CDR3-x having the amino acid sequence SEQ ID NO:13, wherein the hypervariable regions are according to the Chothia definition; and (c) a V L which comprises in sequence hypervariable regions CDR1', CDR2' and CDR3', said CDR1' having the amino acid sequence SEQ ID NO:4, said CDR2' having the amino acid sequence SEQ ID NO:5, and said CDR3' having the amino acid sequence SEQ ID NO:6 wherein the hypervariable regions are according to the Kabat definition. (a) a V H which comprises in sequence hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence SEQ ID NO:1, said CDR2 having the amino acid sequence SEQ ID NO:2, and said CDR3 having the amino acid sequence SEQ ID NO:3, wherein the hypervariable regions are according to the Kabat definition; or (b) a V H which comprises in sequence hypervariable regions CDR1-x, CDR2-x and CDR3-x, said CDR1-x having the amino acid sequence SEQ ID NO:11, said CDR2-x having the amino acid sequence SEQ ID NO:12, and said CDR3-x having the amino acid sequence SEQ ID NO:13, wherein the hypervariable regions are according to the Chothia definition; and (c) a V L which comprises in sequence hypervariable regions CDR1', CDR2' and CDR3', said CDR1' having the amino acid sequence SEQ ID NO:4, said CDR2' having the amino acid sequence SEQ ID NO:5, and said CDR3' having the amino acid sequence SEQ ID NO:6 wherein the hypervariable regions are according to the Kabat definition.
A humanized chimeric monoclonal antibody specific for carcinoembryonic antigen, wherein the monoclonal antibody comprises a heavy chain comprising CDR regions as set forth in SEQ ID NOs: 7-9, and a light chain comprising CDR regions as set forth in SEQ ID NOs: 10-12.
An automatic calibration method for a robot system, comprising steps of: S100: calibrating intrinsic parameters of a sensor and calibrating a sensor coordinate system (O c) of the calibrated sensor with respect to a world coordinate system by means of a calibration target; and S200: defining a first target point in the world coordinate system, and recognizing the first target point by using the calibrated sensor, and controlling a robot under the guidance of the calibrated sensor to move an original point of a tool coordinate system (O t) of a tool mounted on the robot to reach the same first target point with a first group of different poses, and calculating a first transfer matrix tcp T t of the tool coordinate system (O t) with respect to a tool center point coordinate system (O tcp) of the robot based on pose data of the robot at the same first target point. S100: calibrating intrinsic parameters of a sensor and calibrating a sensor coordinate system (O c) of the calibrated sensor with respect to a world coordinate system by means of a calibration target; and S200: defining a first target point in the world coordinate system, and recognizing the first target point by using the calibrated sensor, and controlling a robot under the guidance of the calibrated sensor to move an original point of a tool coordinate system (O t) of a tool mounted on the robot to reach the same first target point with a first group of different poses, and calculating a first transfer matrix tcp T t of the tool coordinate system (O t) with respect to a tool center point coordinate system (O tcp) of the robot based on pose data of the robot at the same first target point.
A travelling pipe cutter adapted to perform cutting-through or beveling of a hollow vessel while travelling around the hollow vessel, comprising: - a carriage; - a cutting tool (270, 270') attached to the carriage, the cutting tool (270, 270') adapted to perform cutting-through or beveling of the hollow vessel while travelling around the hollow vessel, characterized in that the cutting tool (270, 270') comprises - a conical member; - a plurality of grooves disposed in a semi-helix around an outer conical surface of the conical member; and - a plurality of cutting members, wherein each of the cutting members is disposed in fixed position within one of the plurality of grooves at a non-zero angle relative to a vertical axis of the cutting tool, wherein the cutting tool (270, 270') further comprising a hollow shaft passing from a top surface of the conical member through a bottom surface of the conical member, and a drive shaft which is attached to and within the hollow shaft with the drive shaft adapted to rotate the conical member. - a carriage; - a cutting tool (270, 270') attached to the carriage, the cutting tool (270, 270') adapted to perform cutting-through or beveling of the hollow vessel while travelling around the hollow vessel, - a conical member; - a plurality of grooves disposed in a semi-helix around an outer conical surface of the conical member; and - a plurality of cutting members, wherein each of the cutting members is disposed in fixed position within one of the plurality of grooves at a non-zero angle relative to a vertical axis of the cutting tool, wherein the cutting tool (270, 270') further comprising a hollow shaft passing from a top surface of the conical member through a bottom surface of the conical member, and a drive shaft which is attached to and within the hollow shaft with the drive shaft adapted to rotate the conical member.
A magnetic attachment unit for magnetically attaching together at least individual first electronic and second electronic devices (302, 304) each having an associated magnetic attachment feature (1200, 1300), the magnetically attached electronic devices operable to communicate with each other when magnetically attached, comprising: a body having a first side and a second side opposite the first side and comprising communication resources to assist in the communication between the first and second electronic devices, and a data storage device arranged to store data; a first magnetic attachment system at a first side of the body comprising at least a first magnet arranged to provide a first activation force for activating the corresponding magnetic attachment feature (1200, 1300) in the first electronic device; and a second magnetic attachment system at a second side of the body comprising at least a second magnet arranged to provide a second activation force for activating the corresponding magnetic attachment feature (1200, 1300) in the second electronic device, wherein a magnetic attachment force generated between the activated first and second magnetic attachment features and the corresponding magnets in the magnetic attachment unit results in the first and second individual electronic devices being operable together as a cooperating electronic device. a body having a first side and a second side opposite the first side and comprising communication resources to assist in the communication between the first and second electronic devices, and a data storage device arranged to store data; a first magnetic attachment system at a first side of the body comprising at least a first magnet arranged to provide a first activation force for activating the corresponding magnetic attachment feature (1200, 1300) in the first electronic device; and a second magnetic attachment system at a second side of the body comprising at least a second magnet arranged to provide a second activation force for activating the corresponding magnetic attachment feature (1200, 1300) in the second electronic device, wherein a magnetic attachment force generated between the activated first and second magnetic attachment features and the corresponding magnets in the magnetic attachment unit results in the first and second individual electronic devices being operable together as a cooperating electronic device.
A method for navigating through notifications on a wireless device having a primary user interface shown on a primary display and a secondary user interface shown on a secondary display, the method comprising: generating a notification associated with an event at the wireless device, the event including an incoming electronic message; detecting whether the secondary user interface is shown; indicating the notification on the secondary user interface when the secondary user interface is shown on the secondary display which displays identifiers of a plurality of users, wherein the notification on the secondary display includes indicating an identifier of one of the plurality of users on the secondary display as the user associated with the electronic message; indicating the notification on the primary user interface when the secondary user interface is not shown on the secondary display; displaying a preview of the event on the secondary user interface in a preview mode in response to a selection of the notification, the preview including at least a portion of message contents; and closing the preview of the event on the secondary user interface in response to a deselection of the notification. generating a notification associated with an event at the wireless device, the event including an incoming electronic message; detecting whether the secondary user interface is shown; indicating the notification on the secondary user interface when the secondary user interface is shown on the secondary display which displays identifiers of a plurality of users, wherein the notification on the secondary display includes indicating an identifier of one of the plurality of users on the secondary display as the user associated with the electronic message; indicating the notification on the primary user interface when the secondary user interface is not shown on the secondary display; displaying a preview of the event on the secondary user interface in a preview mode in response to a selection of the notification, the preview including at least a portion of message contents; and closing the preview of the event on the secondary user interface in response to a deselection of the notification.
An acrylic elastomer copolymer that is a copolymer of an alkyl (meth)acrylate and/or alkoxyalkyl (meth)acrylate monomer, an α,β-unsaturated carboxylic acid monomer, and a (meth)acrylate monomer having a carbamic acid ester group represented by the general formula: wherein R 1 is a hydrogen atom or a methyl group, and R 2 is a divalent aliphatic hydrocarbon group having 1 to 10 carbon atoms.
A pigment epithelium-derived factor (PEDF) for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject, wherein said agent is a chemotherapy which induces oxidative stress.
Method for calibrating a fully hydraulic steering system of a vehicle having steered wheels and a hydraulic steering motor, in which method the steered wheels are moved by the steering motor in one direction until they reach a first end position and are then moved in the opposite direction until they reach a second end position, characterized in that the steering motor is supplied with a constant flow of hydraulic fluid and the time of movement between the one end position of the steered wheels and the other end position of the steered wheels is determined, wherein a neutral position of the steering motor is adjusted by supplying the constant flow to the steering motor over half of the determined time.
Fixing and/or locking system for containers on a fastening device, in particular on a carrier such as a luggage carrier in which at least one fastening element is applied on the carrier and in which one receiving element, which is applied a container and/or is connected thereto, engages and can be detachable locked to, wherein the receiving element comprises a base plate with a spring-loaded pusher extending between said plate and a cover plate, characterised in that the cover plate has an upper elevation and a lower elevation and the upper elevation has an undercut, and wherein the cover plate has an aperture from one side of the cover plate to the other, wherein disposed behind the lower elevation is the area for the spring-loaded pusher, and disposed behind the upper elevation the space with its undercut for engagement of the projection or collar of a fastening element, wherein the spring-loaded fastening element which can be pushed into the aperture presses into and fixes in a recess in the upper elevation of the cover plate.
An electrode stacking device configured to stack a packaged electrode made by providing a first electrode in a bag-shaped separator on a second electrode having different polar characteristics from that of the first electrode on a stacking stage, comprising: a detector configured to detect position of the first electrode supplied onto an XY stage by use of light-permeability of the separator and light-impermeability of the first electrode; a position adjustment unit that is provided at the supply unit, and includes the XY stage from which the packaged electrode is picked up, the position adjustment unit being configured to adjust position of the packaged electrode, by moving the XY stage in a planar direction, on the basis of the position of the first electrode detected by the detector so that the first electrode is positioned in a predetermined position to be picked up; and a stacking unit that includes a suction hand, the stacking unit being configured to pick up, from the XY stage by the suction hand, the packaged electrode whose position had been adjusted by the position adjustment unit, move the packaged electrode above the second electrode being mounted on the stacking stage, and then release the packaged electrode from the suction hand to stack the packaged electrode on the second electrode. a detector configured to detect position of the first electrode supplied onto an XY stage by use of light-permeability of the separator and light-impermeability of the first electrode; a position adjustment unit that is provided at the supply unit, and includes the XY stage from which the packaged electrode is picked up, the position adjustment unit being configured to adjust position of the packaged electrode, by moving the XY stage in a planar direction, on the basis of the position of the first electrode detected by the detector so that the first electrode is positioned in a predetermined position to be picked up; and a stacking unit that includes a suction hand, the stacking unit being configured to pick up, from the XY stage by the suction hand, the packaged electrode whose position had been adjusted by the position adjustment unit, move the packaged electrode above the second electrode being mounted on the stacking stage, and then release the packaged electrode from the suction hand to stack the packaged electrode on the second electrode.
An adjustable supporting structure with at least one raising and lowering mechanism for a medical and/or therapeutic device, in particular for a podology chair, the device having at least two lifting segments (10a, 10b), wherein the lifting segments (10a, 10b) are arranged above and below at least one intermediate member, which has at least one elongate hole, and the segments are each assembled from the at least one intermediate member, at least one bracket (40, 50) and at least two pivot arms (12, 16, 22, 26) which are hingedly connected to intermediate member and bracket and are coupled to each other and form a parallelogram structure, wherein there is provided a synchronising mechanism hingedly connected to the lifting segments (10a, 10b) for coupling between the lifting segments, wherein the synchronising mechanism comprises at least two elements connected to each other and positively guided in the elongate hole of the intermediate member, characterised in that the synchronising mechanism is formed by at least one synchronising lever, which comprises as the positively-guided elements at least two stabilising levers (14, 24) hingedly linked to each other, and in that the supporting structure has a driver element which engages with a lifting segment (10a, 10b) and is driven by a motor. wherein there is provided a synchronising mechanism hingedly connected to the lifting segments (10a, 10b) for coupling between the lifting segments, wherein the synchronising mechanism comprises at least two elements connected to each other and positively guided in the elongate hole of the intermediate member, characterised in that the synchronising mechanism is formed by at least one synchronising lever, which comprises as the positively-guided elements at least two stabilising levers (14, 24) hingedly linked to each other, and in that the supporting structure has a driver element which engages with a lifting segment (10a, 10b) and is driven by a motor.
A method of detecting rainout in a respiratory therapy system, the method comprising: generating, via at least one microphone, first acoustic data representative of noise associated with the respiratory therapy system; analyzing the first acoustic data to detect a presence of liquid in the respiratory therapy system; transmitting, to a user of the respiratory therapy system, (i) a notification of the presence of the liquid in the respiratory therapy system characterized in that the method further comprises the steps of transmitting (ii) a recommendation for action to reduce or remove the liquid in the respiratory therapy system; generating, via the at least one microphone, second acoustic data representative of noise associated with the respiratory therapy system; analyzing the second acoustic data to determine an amount of the liquid remaining in the respiratory therapy system following the action; and in response to determining that the amount of the liquid remaining in the respiratory therapy system is less than a threshold amount, transmitting to the user a notification that the amount of liquid remaining in the respiratory therapy system is less than the threshold amount. generating, via at least one microphone, first acoustic data representative of noise associated with the respiratory therapy system; analyzing the first acoustic data to detect a presence of liquid in the respiratory therapy system; transmitting, to a user of the respiratory therapy system, (i) a notification of the presence of the liquid in the respiratory therapy system characterized in that the method further comprises the steps of transmitting (ii) a recommendation for action to reduce or remove the liquid in the respiratory therapy system; generating, via the at least one microphone, second acoustic data representative of noise associated with the respiratory therapy system; analyzing the second acoustic data to determine an amount of the liquid remaining in the respiratory therapy system following the action; and in response to determining that the amount of the liquid remaining in the respiratory therapy system is less than a threshold amount, transmitting to the user a notification that the amount of liquid remaining in the respiratory therapy system is less than the threshold amount.
A light emitting device comprising: a substrate having a wiring pattern on an upper face thereof; a light emitting element mounted on the wiring pattern of the substrate in a flip-chip manner, the light emitting element including a semiconductor stack successively having a first semiconductor layer, an emission layer, and a second semiconductor layer, with the first semiconductor layer having a plurality of exposed portions exposed from the second semiconductor layer on an upper face side of the second semiconductor layer, an insulation film covering the semiconductor stack and having a plurality of openings respectively above the exposed portions of the first semiconductor layer, a first electrode connected to the exposed portions of the first semiconductor layer at the openings of the insulation film and partially disposed over the second semiconductor layer via the insulation film, and a second electrode connected to the second semiconductor layer; a plurality of bumps (15, 16) disposed between the substrate and the light emitting element to mount the light emitting element on the substrate, the bumps including a plurality of first bumps bonded to the first electrode, and a plurality of second bumps bonded to the second electrode, the first bumps being spaced apart from the exposed portions of the first semiconductor layer, and a cover member covering the light emitting element, the bumps, and the substrate characterized in that the first bumps include a plurality of large bumps and a plurality of small bumps each having a smaller surface area than each of the large bumps in a plan view. a substrate having a wiring pattern on an upper face thereof; a light emitting element mounted on the wiring pattern of the substrate in a flip-chip manner, the light emitting element including a semiconductor stack successively having a first semiconductor layer, an emission layer, and a second semiconductor layer, with the first semiconductor layer having a plurality of exposed portions exposed from the second semiconductor layer on an upper face side of the second semiconductor layer, an insulation film covering the semiconductor stack and having a plurality of openings respectively above the exposed portions of the first semiconductor layer, a first electrode connected to the exposed portions of the first semiconductor layer at the openings of the insulation film and partially disposed over the second semiconductor layer via the insulation film, and a second electrode connected to the second semiconductor layer; a plurality of bumps (15, 16) disposed between the substrate and the light emitting element to mount the light emitting element on the substrate, the bumps including a plurality of first bumps bonded to the first electrode, and a plurality of second bumps bonded to the second electrode, the first bumps being spaced apart from the exposed portions of the first semiconductor layer, and a cover member covering the light emitting element, the bumps, and the substrate characterized in that the first bumps include a plurality of large bumps and a plurality of small bumps each having a smaller surface area than each of the large bumps in a plan view.
A bioabsorbable macromer composition of the formula selected from the group consisting of R 1 - v -R 2 -R 3 and R 3 -R 2 - v -R 1 - v -R 2 -R 3 wherein R 1 comprises a hydroxamate segment, R 2 comprises a polymer selected from the group consisting of polysaccharides and polyols, R 3 comprises a functional group selected from the group consisting of isocyanates, succinimides, aldehydes, and combinations thereof, A is a bioabsorbable group, and v is a number from 1 to 20.