A method for purifying a ribonucleic acid transcript comprising a polyA tail, the method comprising: a) contacting: (i) a first obtained sample comprising the RNA transcript, wherein the first sample comprises at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% RNA transcript and at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% impurities, and wherein the percentage of RNA transcript and the percentage of impurities are the inverse of each other, with (ii) a surface linked to a polythymidine that is twenty thymidines in length under conditions such that the RNA transcript binds to the surface, wherein the polythymidine is linked to the surface via a secondary amine linker obtainable by contacting a surface attached to an epoxide with a polythymidine attached to an amino group, wherein the amino group is located at the 5' end of the polythymidine; b) eluting the RNA transcript from the surface; and c) collecting the RNA transcript in a second sample, wherein the second sample comprises at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% RNA transcript and no more than less than 1%, 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% impurities, and wherein the percentage of RNA transcript and the percentage of impurities are the inverse of each other. a) contacting: (i) a first obtained sample comprising the RNA transcript, wherein the first sample comprises at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% RNA transcript and at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% impurities, and wherein the percentage of RNA transcript and the percentage of impurities are the inverse of each other, with (ii) a surface linked to a polythymidine that is twenty thymidines in length under conditions such that the RNA transcript binds to the surface, wherein the polythymidine is linked to the surface via a secondary amine linker obtainable by contacting a surface attached to an epoxide with a polythymidine attached to an amino group, wherein the amino group is located at the 5' end of the polythymidine; (i) a first obtained sample comprising the RNA transcript, wherein the first sample comprises at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% RNA transcript and at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% impurities, and wherein the percentage of RNA transcript and the percentage of impurities are the inverse of each other, with (ii) a surface linked to a polythymidine that is twenty thymidines in length under conditions such that the RNA transcript binds to the surface, wherein the polythymidine is linked to the surface via a secondary amine linker obtainable by contacting a surface attached to an epoxide with a polythymidine attached to an amino group, wherein the amino group is located at the 5' end of the polythymidine; b) eluting the RNA transcript from the surface; and c) collecting the RNA transcript in a second sample, wherein the second sample comprises at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% RNA transcript and no more than less than 1%, 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% impurities, and wherein the percentage of RNA transcript and the percentage of impurities are the inverse of each other.