A catheter device (20, 50, 70, 90, 100, 120, 200, 300, 320) for treating a lesion of a patient comprising: a pulse generator adapted for propagating at least one short duration pulsed mechanical wave; an internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) extending between a proximal end and a distal end along a longitudinal axis, the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) defining a longitudinal aperture that extends between the proximal and distal ends (24, 26) thereof, the longitudinal aperture being shaped and sized for receiving a guide wire therein to be inserted through the distal end of the longitudinal aperture up to the proximal end for positioning the catheter device relative to the lesion to be treated; and at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) secured to the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) and extending longitudinally along at least a portion of the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324), a distal end (98,212) of the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being in direct contact with the lesion, the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being operatively connectable at a proximal end to the pulse generator, the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being adapted for propagating the at least one short duration pulsed mechanical wave from the proximal end therealong up to the distal end (98, 212) for treating the lesion. a pulse generator adapted for propagating at least one short duration pulsed mechanical wave; an internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) extending between a proximal end and a distal end along a longitudinal axis, the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) defining a longitudinal aperture that extends between the proximal and distal ends (24, 26) thereof, the longitudinal aperture being shaped and sized for receiving a guide wire therein to be inserted through the distal end of the longitudinal aperture up to the proximal end for positioning the catheter device relative to the lesion to be treated; and at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) secured to the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324) and extending longitudinally along at least a portion of the internal elongated and hollow body (28, 54, 74, 94, 104, 124, 204, 304, 324), a distal end (98,212) of the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being in direct contact with the lesion, the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being operatively connectable at a proximal end to the pulse generator, the at least one mechanical waveguide (32, 34, 36, 38, 56, 76, 78, 96, 106, 126, 206, 306, 326) being adapted for propagating the at least one short duration pulsed mechanical wave from the proximal end therealong up to the distal end (98, 212) for treating the lesion.