A compound of formula 1 wherein R 1 is selected from among -O-R 3 or -NR 3 R 4 wherein R 3 is C 1-6 -alkyl which is substituted by R 5 and R 6 wherein R 5 is selected from hydrogen, branched or linear C 1-6 -alkyl, C 2-6 -alkenyl, -C 1- 6-alkylen-O-C 1-3 -alkyl, C 1-3 -haloalkyl, wherein R 6 is ring X wherein n is either 0 or 1, wherein is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH 2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C 1-3 -alkyl, -C 1-3 -haloalkyl, - O-C 1-3 -alkyl, -C 1-3 -alkanol and halogen, R 4 is selected from the group consisting of hydrogen and C 1-6 -Alkyl, R 2 is selected from the group consisting of hydrogen; 5- to 10-membered aryl; 5- to 10-membered heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from among N, O and S; 5- to membered, saturated or partially unsaturated heterocyclus comprising 1, 2 or 3 heteroatoms each individually selected from among N, O and S; 3- to 10-membered saturated or partially unsaturated cycloalkyl, wherein - in case that R 2 is not hydrogen - said R 2 may optionally be substituted by 1, 2, 3 or 4 residues each individually selected from the group consisting of hydrogen, -oxo, halogen, -C 1-6 -alkyl, -C 2-6 -alkenyl, -C 1-6 -alkylene-COOH, -COOH, -CO-NR 9 R 10, -C 1-6 -alkylene-CO-NR 9 R 10, -C 1-6 -alkylene-NR 9 R 10, -C 1-6 -alkylene-CO-Q, -CO-Q, -C 1-6 -alkylene-CO-NR 9 Q, -CO-NR 9 Q, -C 1-6 -alkylene-NR 11 -CO-NR 9 R 10, -C 1-6 -alkylene-NR 11 -CO-Q, -C 1-6 -alkylene-NR 11 -SO 2 R 9 -C 1-6 -alkylene-O-CO-R 9, -C 1-6 -alkylene-O-CO-NR 9 R 10, -C 1-6 -alkylene-O-R 9, -C 1-6 -alkylene-SO-NR 9 R 10, -C 1-6 -alkylene-SO 2 R 9, -C 1-6 -alkylene-SOR 9, -C 1-6 -alkinylene-O-R 9, -C 1-6 -alkinylene-Q, -C 1-6 -alkinylene-NR 9 R 10, C 5-10 -aryl, -Q, -C 3-8 -cycloalkyl, -O-R 7, -O-C 1-6 -alkylene-R 7, -O-C 1-6 -alkylene-O-R 7, -C 1-3 -haloalkyl, cyanide,, -NR 11 (C 1-6 -alkylene-R 7), -S -C 1-6 -alkyl, -SO 2 -C 1-6 -alkyl, -S-C 1-6 -alkyl, -SO 2 -NR 9 R 10, -SO 2 -NR 11 Q, 5- to 10-membered heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from among N, O and S, -NR 11 -CO-R 7 and -O-CO-R 7, wherein R 7 is selected from the group consisting of hydrogen; branched or linear -C 1-6 -alkyl; -C 1-6 -haloalkyl; -C 1-6 -alkylene-COOH; -C 1-6 -alkylen-CO-NR 9 R 10; -C 1-6 -alkylene-CO-Q; -C 2-6 -alkylene-NR 11 -CO-NR 9 R 10; -C 2-6 -alkylene-NR 11 -CO-Q; -C 2-6 -alkylene-NR 11 -SO 2 R 9; -C 2-6 -alkylene-NR 9 R 10; -C 2-6 -alkylene-Q; -C 2-6 -alkylene-O-CO-R 9, -C 2-6 -alkylene-O-CO-NR 9 R 10, -C 2-6 -alkylene-SO-NR 9 R 10, -C 2-6 -alkylene-SO 2 -R 9, -C 2-6 -alkylene-SO-R 9, -SO 2 -R 9, -SO-R 9, -SO 2 -NR 9 R 10, -SO 2 -NR 11 Q, -SO 2 -Q -C 1-6 -alkylene-O-R 9; -CO-NR 9 R 10, -CO-NR 9 Q, -CO-R 9, -CO-Q, -C 1-6 -alkylene-Q, -C 5-10 -aryl, -Q, 3- to 8-membered saturated or partially unsaturated cycloalkyl; 5- to 10-membered heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from among N, O and S; -C 1-6 -alkylene-heteroaryl wherein this heteroaryl is 5- to 10-membered and comprises 1, 2 or 3 heteroatoms each individually selected from among N, O and S; whereby - in case that R 7 is not hydrogen - R 7 may optionally be substituted by 1, 2 or 3 residues R 8 that are individually selected from the group consisting of hydrogen; -oxo; hydroxy; -C 1-6 -alkyl; -C 1-6 -haloalkyl; -NR 9 R 10, -Q, -NR 9 Q, 3- to 6-membered saturated or partially unsaturated cycloalkyl; whereby - in case that R 8 is not hydrogen - R 3 may optionally be substituted by 1, 2 or 3 residues selected from hydrogen, -oxo, hydroxy, -C 1-6 -alkyl, halogen, -C 1-6 -haloalkyl, -O-C 1-6 -alkyl, -C 1-3 -alkylene-O-C 1-3 -alkyl, wherein each of R 9, R 10 and R 11 is individually from one another selected from the group consisting of hydrogen, -C 1-6 -alkyl, -C 3-8 -cycloalkyl, -C 1-6 -alkyl-C 3-8 -Cycloalkyl and phenyl, and wherein each Q is individually selected either from a 5- to 10-membered saturated or partially unsaturated heterocyclus comprising 1, 2 or 3 heteroatoms each individually selected from among N, O or S or from a 5- to 10-membered heteroaryl comprising 1, 2 or 3 heteroatoms each individually selected from among N, O and S; whereby Q is attached to the rest of the molecule either via a carbon atom or via an nitrogen atom, the N-oxides of the aforementioned compounds and the pharmaceutically acceptable salts of the aforementioned compounds.