A compound having the following structure: wherein L 1 is selected from O and NR 5, wherein n is 0 or 1; wherein R 5 is selected from hydrogen and C1-C6 alkyl; wherein L 2 is selected from CH 2 and NCH 3, provided that L 2 is CH 2 when Y is N; wherein Y is selected from CH or N; wherein Z is selected from NR 6 and CH 2; wherein R 6 is selected from hydrogen and CH 3; wherein each of R 1a and R 1b is independently selected from hydrogen, halogen, OH, CN, SO 2 CH 3, C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 polyhaloalkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, and NH(C=O)R 7; wherein R 7 is selected from hydrogen and C1-C6 alkyl; wherein R 2 is SO 2 R 8; wherein R 8 is selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, and NR 10 R 11; wherein R 10 is selected from hydrogen, C1-C6 alkyl, and C3-C6 cycloalkyl; and wherein R 11, when present, is selected from hydrogen and C1-C6 alkyl; or R 10 and R 11 are covalently bonded and, together with the intermediate nitrogen, comprise an optionally substituted 3-7 membered heterocycloalkyl ring; wherein R 3 is a halogen; and wherein R 4 is selected from hydrogen, halogen, Ar 1, C1-C6 alkyl, C3-C6 cycloalkyl, and C3-C6 heterocycloalkyl; wherein Ar 1 is either phenyl substituted with 0-3 substituents independently selected from cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 12, C1-C3 alkyl, C1-C3 alkylamine, and C1-C3 dialkylamino or is monocyclic heteroaryl substituted with 0-3 substituents independently selected from halo, cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 12, C1-C3 alkyl, C1-C3 alkylamine, and C1-C3 dialkylamino; wherein R 12 is selected from C1-C6 alkyl and C3-C6 cycloalkyl; or a pharmaceutically acceptable salt, hydrate, solvate, or polymorph thereof. wherein L 1 is selected from O and NR 5, wherein n is 0 or 1; wherein R 5 is selected from hydrogen and C1-C6 alkyl; wherein L 2 is selected from CH 2 and NCH 3, provided that L 2 is CH 2 when Y is N; wherein Y is selected from CH or N; wherein Z is selected from NR 6 and CH 2; wherein R 6 is selected from hydrogen and CH 3; wherein each of R 1a and R 1b is independently selected from hydrogen, halogen, OH, CN, SO 2 CH 3, C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 polyhaloalkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, and NH(C=O)R 7; wherein R 7 is selected from hydrogen and C1-C6 alkyl; wherein R 2 is SO 2 R 8; wherein R 8 is selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, and NR 10 R 11; wherein R 10 is selected from hydrogen, C1-C6 alkyl, and C3-C6 cycloalkyl; and wherein R 11, when present, is selected from hydrogen and C1-C6 alkyl; or R 10 and R 11 are covalently bonded and, together with the intermediate nitrogen, comprise an optionally substituted 3-7 membered heterocycloalkyl ring; wherein R 3 is a halogen; and wherein R 4 is selected from hydrogen, halogen, Ar 1, C1-C6 alkyl, C3-C6 cycloalkyl, and C3-C6 heterocycloalkyl; wherein Ar 1 is either phenyl substituted with 0-3 substituents independently selected from cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 12, C1-C3 alkyl, C1-C3 alkylamine, and C1-C3 dialkylamino or is monocyclic heteroaryl substituted with 0-3 substituents independently selected from halo, cyano, C1-C6 alkyl, C1-C6 haloalkyoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 cyanoalkyl, SO 2 R 12, C1-C3 alkyl, C1-C3 alkylamine, and C1-C3 dialkylamino; wherein R 12 is selected from C1-C6 alkyl and C3-C6 cycloalkyl;