A compound of Formula I or Formula II where: R 1 is -CON(R 7)(R 8); or R 1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, indolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, or phenyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkenyl, alkoxy, alkenoxy, Ar 1, (Ar 1)alkyl, and (Ar 1)O; R 2 is hydrogen or alkyl; R 3 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy, and phenyl; or R 3 is cycloalkyl, cycloalkenyl, chromanyl, oxazinyl, or dihydropyranoquinolinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy, and phenyl; R 4 is alkyl or haloalkyl; R 5 is alkyl; R 6 is hydrogen or alkyl; R 7 is Ar 1 or (Ar 1)alkyl; R 8 is hydrogen or alkyl; Ar 1 is phenyl or pyridinyl and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, and alkenyloxy; x 1 is -CONH-; or X 1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, benzimidazolyl, or phenyl; X 2 is phenyl or benzyl and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; X 3 is O or absent; X 4 is alkylene or alkenylene; X 5 is O or absent; and X 6 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 halo or alkyl substituents; or a pharmaceutically acceptable salt thereof. R 1 is -CON(R 7)(R 8); or R 1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, indolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, or phenyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkenyl, alkoxy, alkenoxy, Ar 1, (Ar 1)alkyl, and (Ar 1)O; R 2 is hydrogen or alkyl; R 3 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy, and phenyl; or R 3 is cycloalkyl, cycloalkenyl, chromanyl, oxazinyl, or dihydropyranoquinolinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, alkenyloxy, and phenyl; R 4 is alkyl or haloalkyl; R 5 is alkyl; R 6 is hydrogen or alkyl; R 7 is Ar 1 or (Ar 1)alkyl; R 8 is hydrogen or alkyl; Ar 1 is phenyl or pyridinyl and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, and alkenyloxy; x 1 is -CONH-; or X 1 is pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, benzimidazolyl, or phenyl; X 2 is phenyl or benzyl and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; X 3 is O or absent; X 4 is alkylene or alkenylene; X 5 is O or absent; and X 6 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 halo or alkyl substituents;