A surgical system for providing transabdominal access for surgical instruments through a surgically constructed opening between an external body surface, the abdominal wall, and the stomach of a patient, the system comprising: a cannula including an inner end, an opposed outer end, and a sidewall extending between the ends, the sidewall circumscribing a lumen; an internal anchor assembly connected with the cannula adjacent the inner end, the internal anchor assembly being actuable between a non-deployed position to a deployed position disposed to contact the inner wall of the stomach; at least one external anchor for securing an outer portion of the cannula in place in the surgical opening adjacent the external surface, the external anchor selected from an array of anchor discs,,, each disc including an aperture sized for receiving the cannula there through; a cap including a plurality of access ports for introduction of surgical instruments through the cannula lumen and into the stomach of the patient; wherein the access ports have various angular orientations for simultaneous access to a plurality of surgical instruments at different angular orientations; a gas insufflation port connected to the cap for insufflation of a gas to the stomach to provide gastric distension; the access ports each including a double-seal disposed to reduce contamination of the cannula lumen and maintain intragastric insufflation by preventing escape of insufflated gas; and, the access ports configured to provide instrument access to the interior of the stomach of the patient at a plurality of different angles, further comprising an insertion tool connected to the cannula, wherein the cannula has an external anchor removed configuration, for retrograde introduction of the system for transabdominal gastric access. a cannula including an inner end, an opposed outer end, and a sidewall extending between the ends, the sidewall circumscribing a lumen; an internal anchor assembly connected with the cannula adjacent the inner end, the internal anchor assembly being actuable between a non-deployed position to a deployed position disposed to contact the inner wall of the stomach; at least one external anchor for securing an outer portion of the cannula in place in the surgical opening adjacent the external surface, the external anchor selected from an array of anchor discs,,, each disc including an aperture sized for receiving the cannula there through; a cap including a plurality of access ports for introduction of surgical instruments through the cannula lumen and into the stomach of the patient; wherein the access ports have various angular orientations for simultaneous access to a plurality of surgical instruments at different angular orientations; a gas insufflation port connected to the cap for insufflation of a gas to the stomach to provide gastric distension; the access ports each including a double-seal disposed to reduce contamination of the cannula lumen and maintain intragastric insufflation by preventing escape of insufflated gas; and, the access ports configured to provide instrument access to the interior of the stomach of the patient at a plurality of different angles, further comprising an insertion tool connected to the cannula, wherein the cannula has an external anchor removed configuration, for retrograde introduction of the system for transabdominal gastric access.