A device for the local application of and/or for flushing with pharmaceutical fluids, said device having at least one bone screw, said at least one bone screw having a screw body, an outer thread and a proximal screw head, wherein at least one conduit is disposed in the screw body, wherein the at least one conduit is fluid-permeable, begins at the screw head and opens out into at least one fluid outlet opening in the screw body, wherein the at least one fluid outlet opening is spaced apart from the screw head in the distal direction, at least one axial groove that penetrates the outer thread of the bone screw, which extends from the at least one fluid outlet opening in the screw body through to the screw head, wherein a base of the groove of the at least one axial groove is deeper in the screw body as a base of the outer thread, at least one cap (5, 6, 7, 8, 9) with a connecting element for the detachable connection of the at least one cap (5, 6, 7, 8, 9) with the proximal screw head of the at least one bone screw, wherein a fluid-permeable conduit is arranged in the at least one cap (5, 6, 7, 8, 9), wherein said conduit in the at least one cap (5, 6, 7, 8, 9) opens out into the at least one conduit of the at least one bone screw, when the at least one cap (5, 6, 7, 8, 9) is detachably connected via the connecting element to the at least one bone screw, and wherein the conduit begins at an inlet opening in the at least one cap (5, 6, 7, 8, 9), characterized in that the device comprises at least one hose (10, 14, 46, 54) for feeding fluid, which is connected or connectable in a fluid-permeable manner with the inlet opening on one of the at least one cap (5, 6, 7, 8, 9), so that a pharmaceutical fluid is pressable from the at least one fluid outlet opening with a pressure through the at least one hose (10, 14, 46, 54) for feeding fluid, through the conduit of the at least one cap (5, 6, 7, 8, 9) and through the at least one conduit of the at least one bone screw, when the at least one hose (10, 14, 46, 54) for feeding fluid is connected to the at least one cap (5, 6, 7, 8, 9) and the at least one cap (5, 6, 7, 8, 9) is connected via the connecting element with the at least one bone screw. at least one bone screw, said at least one bone screw having a screw body, an outer thread and a proximal screw head, wherein at least one conduit is disposed in the screw body, wherein the at least one conduit is fluid-permeable, begins at the screw head and opens out into at least one fluid outlet opening in the screw body, wherein the at least one fluid outlet opening is spaced apart from the screw head in the distal direction, at least one axial groove that penetrates the outer thread of the bone screw, which extends from the at least one fluid outlet opening in the screw body through to the screw head, wherein a base of the groove of the at least one axial groove is deeper in the screw body as a base of the outer thread, at least one cap (5, 6, 7, 8, 9) with a connecting element for the detachable connection of the at least one cap (5, 6, 7, 8, 9) with the proximal screw head of the at least one bone screw, wherein a fluid-permeable conduit is arranged in the at least one cap (5, 6, 7, 8, 9), wherein said conduit in the at least one cap (5, 6, 7, 8, 9) opens out into the at least one conduit of the at least one bone screw, when the at least one cap (5, 6, 7, 8, 9) is detachably connected via the connecting element to the at least one bone screw, and wherein the conduit begins at an inlet opening in the at least one cap (5, 6, 7, 8, 9), characterized in that the device comprises at least one hose (10, 14, 46, 54) for feeding fluid, which is connected or connectable in a fluid-permeable manner with the inlet opening on one of the at least one cap (5, 6, 7, 8, 9), so that a pharmaceutical fluid is pressable from the at least one fluid outlet opening with a pressure through the at least one hose (10, 14, 46, 54) for feeding fluid, through the conduit of the at least one cap (5, 6, 7, 8, 9) and through the at least one conduit of the at least one bone screw, when the at least one hose (10, 14, 46, 54) for feeding fluid is connected to the at least one cap (5, 6, 7, 8, 9) and the at least one cap (5, 6, 7, 8, 9) is connected via the connecting element with the at least one bone screw.