Method for desorption of a blood sample from a medical test sheet comprising at least one dried blood spot thereon, for the purpose of biomedical analysis of the blood sample, comprising the steps of: - interposing the test sheet, having first and second opposite faces, inbetween first and second clamping heads, the first clamping head having a first outer surface and the second clamping head having a second outer surface, the first and second outer surfaces facing towards one another, in such manner that the first face of the test sheet is facing towards the first outer surface, while the second face of the test sheet is facing towards the second outer surface; - clamping the first and the second clamping heads in such manner that the first and the second clamping heads in clamped condition are defining a desorption area of the test sheet, which desorption area contains at least part of the at least one dried blood spot and which desorption area of the test sheet is contained in a space enveloped by the first and the second outer surfaces; and - flushing the desorption area of the clamped test sheet with a sample elution fluid in such manner that the blood sample is desorbed and eluted from the desorption area, said flushing taking place via a first fluid conduit extending through the first clamping head and a second fluid conduit extending through the second clamping head, each of the first and second fluid conduits ending in said enveloped space containing the desorption area of the test sheet; characterized in that said clamping of the first and the second clamping heads is onto the thus interposed test sheet and at least one of the first and second outer surfaces has a non-flat shape in such manner that in said clamped condition: - the first and the second clamping are transmitting compressive forces to parts of the test sheet, which compressive forces create an imprinted sealing area of the test sheet, which imprinted sealing area has a closed loop shape surrounding said desorption area of the test sheet; and - said enveloped space is sealed by the imprinted sealing area; wherein the method is performed using an automatic test sheet handling system comprising at least one magazine for storing a plurality of such test sheets, and a pick and place mechanism, which: - prior to the step of said interposing, picks up the test sheet from the at least one magazine; - in-between the step of said interposing and the step of said clamping, precisely positions the test sheet relative to the clamping heads; - after the step of said flushing, moves the test sheet away from the clamping heads, and stores or discards the test sheet. - interposing the test sheet, having first and second opposite faces, inbetween first and second clamping heads, the first clamping head having a first outer surface and the second clamping head having a second outer surface, the first and second outer surfaces facing towards one another, in such manner that the first face of the test sheet is facing towards the first outer surface, while the second face of the test sheet is facing towards the second outer surface; - clamping the first and the second clamping heads in such manner that the first and the second clamping heads in clamped condition are defining a desorption area of the test sheet, which desorption area contains at least part of the at least one dried blood spot and which desorption area of the test sheet is contained in a space enveloped by the first and the second outer surfaces; and - flushing the desorption area of the clamped test sheet with a sample elution fluid in such manner that the blood sample is desorbed and eluted from the desorption area, said flushing taking place via a first fluid conduit extending through the first clamping head and a second fluid conduit extending through the second clamping head, each of the first and second fluid conduits ending in said enveloped space containing the desorption area of the test sheet; - the first and the second clamping are transmitting compressive forces to parts of the test sheet, which compressive forces create an imprinted sealing area of the test sheet, which imprinted sealing area has a closed loop shape surrounding said desorption area of the test sheet; and - said enveloped space is sealed by the imprinted sealing area; - prior to the step of said interposing, picks up the test sheet from the at least one magazine; - in-between the step of said interposing and the step of said clamping, precisely positions the test sheet relative to the clamping heads; - after the step of said flushing, moves the test sheet away from the clamping heads, and stores or discards the test sheet.