A compound having Formula, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein: R 1 and R 2 are each independently selected from H; and straight and branched C 1 ―C 8 alkyl, straight and branched C 1 ―C 5 alkoxy, straight and branched C 1 ―C 5 acyl, C 5 ―C 15 aryl, and C 3 ―C 7 heteroaryl, each optionally substituted by at least one of halide, hydroxyl, an ester, an ether, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, and an amide; or R 1 and R 2 together with the nitrogen atom they are connected to form a 4-7 membered saturated, unsaturated, or aromatic ring that optionally includes at least one of N, O, NH, C=N, C=O, and SO 2, and is optionally substituted with at least one of straight or branched C 1 ―C 5 alkyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, hydroxyl, halide, and cyano; R 3 and R 4 are each independently selected from H, and straight and branched C 1 ―C 8 alkyl optionally substituted by at least one of halide, hydroxyl, alkoxy, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, an ester, and an amide; or R 1 or R 2 together with R 3 and the carbon and nitrogen atoms they are each connected to form a 4-7 membered saturated, unsaturated, or aromatic ring that optionally includes at least one of N, NH, O, C=N, C=O, and SO 2, and is optionally substituted with at least one of straight or branched C 1 ―C 5 alkyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, hydroxyl, carbonyl, and halide; W, X, Y, and Z are each selected from CH, CRs, CRsc, NH, N, and S; provided that at least one of W, X, Y and Z is selected from NH, N, and S; and provided that, when W is N and Z is N, then X is CRsc or R 8 is other than H; n is an integer selected from 0 and 1; R 5 is selected from OH, NH 2, and halide; Rsc is selected from OH and NH 2; R 8 is selected from H and halide; and straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, and straight and branched C 2 ―C 8 alkynyl, each optionally substituted by at least one halide; R 6 is selected from straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, straight and branched C 2 ―C 8 alkynyl, C 5 ―C 10 cycloalkyl, and saturated and unsaturated 4-6 membered heterocyclyl, each optionally substituted by at least one of straight or branched C 1 ―C 8 alkyl, C 3 ―C 7 cycloalkyl, 4-6 membered heterocyclyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, halide, hydroxyl, and C 1 ―C 5 haloalkyl; and R 7 is selected from straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, and straight and branched C 2 ―C 8 alkynyl, each independently substituted by at least one of C 3 ―C 7 cycloalkyl, 4-6 membered heterocyclyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, halide, hydroxyl, and C 1 ―C 5 haloalkyl. R 1 and R 2 are each independently selected from H; and straight and branched C 1 ―C 8 alkyl, straight and branched C 1 ―C 5 alkoxy, straight and branched C 1 ―C 5 acyl, C 5 ―C 15 aryl, and C 3 ―C 7 heteroaryl, each optionally substituted by at least one of halide, hydroxyl, an ester, an ether, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, and an amide; or R 1 and R 2 together with the nitrogen atom they are connected to form a 4-7 membered saturated, unsaturated, or aromatic ring that optionally includes at least one of N, O, NH, C=N, C=O, and SO 2, and is optionally substituted with at least one of straight or branched C 1 ―C 5 alkyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, hydroxyl, halide, and cyano; R 3 and R 4 are each independently selected from H, and straight and branched C 1 ―C 8 alkyl optionally substituted by at least one of halide, hydroxyl, alkoxy, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, an ester, and an amide; or R 1 or R 2 together with R 3 and the carbon and nitrogen atoms they are each connected to form a 4-7 membered saturated, unsaturated, or aromatic ring that optionally includes at least one of N, NH, O, C=N, C=O, and SO 2, and is optionally substituted with at least one of straight or branched C 1 ―C 5 alkyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, hydroxyl, carbonyl, and halide; W, X, Y, and Z are each selected from CH, CRs, CRsc, NH, N, and S; provided that at least one of W, X, Y and Z is selected from NH, N, and S; and provided that, when W is N and Z is N, then X is CRsc or R 8 is other than H; n is an integer selected from 0 and 1; R 5 is selected from OH, NH 2, and halide; Rsc is selected from OH and NH 2; R 8 is selected from H and halide; and straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, and straight and branched C 2 ―C 8 alkynyl, each optionally substituted by at least one halide; R 6 is selected from straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, straight and branched C 2 ―C 8 alkynyl, C 5 ―C 10 cycloalkyl, and saturated and unsaturated 4-6 membered heterocyclyl, each optionally substituted by at least one of straight or branched C 1 ―C 8 alkyl, C 3 ―C 7 cycloalkyl, 4-6 membered heterocyclyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, halide, hydroxyl, and C 1 ―C 5 haloalkyl; and R 7 is selected from straight and branched C 1 ―C 8 alkyl, straight and branched C 2 ―C 8 alkenyl, and straight and branched C 2 ―C 8 alkynyl, each independently substituted by at least one of C 3 ―C 7 cycloalkyl, 4-6 membered heterocyclyl, C 5 ―C 15 aryl, C 3 ―C 7 heteroaryl, halide, hydroxyl, and C 1 ―C 5 haloalkyl.