A method for transferring the administration of a therapy from a first medical system to a second medical system, the method comprising: a first electronic drug delivery system that is connected to a patient receiving a patient identifier that corresponds to the patient; the first electronic drug delivery system estimating underlying patient-specific control variables based on (i) a therapy provided for a patient and (ii) an observed patient-specific response to the therapy, wherein the underlying patient-specific control variables enable determination of a dosage based on a model; based on (i) the estimated underlying patient-specific control variables, (ii) the observed patient-specific response to the therapy, and (iii) a therapy objective, the first electronic drug delivery system providing an updated therapy for the patient so as to adapt the therapy to the patient; the first electronic drug delivery system transferring to a remote system a record of the updated therapy provided for the patient and the estimated underlying patient-specific control variables; upon connecting a second electronic drug delivery system to the patient, the second electronic drug delivery system receiving the patient identifier; the second electronic drug delivery system communicating with the remote system to access the record of the updated therapy and the estimated underlying patient-specific control variables associated with the patient identifier; determining a time that the therapy was discontinued by the first electronic drug delivery system and determining based on the time an amount at which to reduce the therapy that was provided; and adjusting the record of the updated therapy to take into account the amount at which to adjust therapy that will be provided by the second electronic drug delivery system, a first electronic drug delivery system that is connected to a patient receiving a patient identifier that corresponds to the patient; the first electronic drug delivery system estimating underlying patient-specific control variables based on (i) a therapy provided for a patient and (ii) an observed patient-specific response to the therapy, wherein the underlying patient-specific control variables enable determination of a dosage based on a model; based on (i) the estimated underlying patient-specific control variables, (ii) the observed patient-specific response to the therapy, and (iii) a therapy objective, the first electronic drug delivery system providing an updated therapy for the patient so as to adapt the therapy to the patient; the first electronic drug delivery system transferring to a remote system a record of the updated therapy provided for the patient and the estimated underlying patient-specific control variables; upon connecting a second electronic drug delivery system to the patient, the second electronic drug delivery system receiving the patient identifier; the second electronic drug delivery system communicating with the remote system to access the record of the updated therapy and the estimated underlying patient-specific control variables associated with the patient identifier; determining a time that the therapy was discontinued by the first electronic drug delivery system and determining based on the time an amount at which to reduce the therapy that was provided; and adjusting the record of the updated therapy to take into account the amount at which to adjust therapy that will be provided by the second electronic drug delivery system,