mhurhangee/ep-ind-claims huggingface dataset:
A computer-assisted method of identifying, designing or screening for a compound that can potentially interact with insulin receptor and/or insulin-like growth factor-1 receptor (IGF-1R), comprising performing structure-based identification, design or screening of a compound based on the compound's interactions with a structure defined by the atomic coordinates of one or more of Appendixes I to VI, or a subset of atomic coordinates of one or more thereof at least representing the C-terminal region of the α-chain of IR, the C-terminal region of the α-chain of IGF-1R, or a mimetic of the C-terminal region of the α-chain of IR and/or IGF-1R, wherein the atomic coordinates define one or more regions of the low affinity binding site of IR for insulin, and/or the low affinity binding site of IGF-1R for IGF, comprising the C-terminal region of the α-chain of IR, the C-terminal region of the α-chain of IGF-1R, or a mimetic of the C-terminal region of the α-chain of IR and/or IGF-1R, wherein the C-terminal region of the α-chain of IR comprises amino acids 693 to 710 of IR α-chain (SEQ ID NO: 13), wherein the C-terminal region of the α-chain of IGF-1R comprises amino acids 681 to 697 of IGF-1R α-chain (SEQ ID NO: 15), and wherein the mimetic of the C-terminal region of the α-chain of IR and/or IGF-1R is S519C16 (SEQ ID NO: 18).
A header for an agricultural harvester comprising: a frame having a floor, a first side wall and a second side wall; a conveyor assembly (20,220) mounted to the frame, the conveyor assembly (20,220) having a rotatable auger (30a,30b,230) configured to rotate at a first rotational speed, at least one conveyor drive mechanism (32a,32b), mounted to one or both of the first side wall and the second side wall and operatively connected to the conveyor assembly (20,220) to drive rotation of the rotatable auger (30a,30b,230); and a feeder assembly (28,228) mounted to the frame, the feeder assembly (28,228) having a rotary device (38,238) rotatably connected to the conveyor assembly (20,220) and configured to rotate; characterized in that the rotary device (38,238) is configured to rotate at a second rotational speed different from the first rotational speed of the rotatable auger (30a,30b,230) and further including a transmission connecting the rotatable auger (30a,30b,230) to the rotary device (38,238) to rotate the rotary device (38,238) at the second rotational speed, the transmission being a planetary gear system or a continuously variable transmission. a frame having a floor, a first side wall and a second side wall; a conveyor assembly (20,220) mounted to the frame, the conveyor assembly (20,220) having a rotatable auger (30a,30b,230) configured to rotate at a first rotational speed, at least one conveyor drive mechanism (32a,32b), mounted to one or both of the first side wall and the second side wall and operatively connected to the conveyor assembly (20,220) to drive rotation of the rotatable auger (30a,30b,230); and a feeder assembly (28,228) mounted to the frame, the feeder assembly (28,228) having a rotary device (38,238) rotatably connected to the conveyor assembly (20,220) and configured to rotate; characterized in that the rotary device (38,238) is configured to rotate at a second rotational speed different from the first rotational speed of the rotatable auger (30a,30b,230) and further including a transmission connecting the rotatable auger (30a,30b,230) to the rotary device (38,238) to rotate the rotary device (38,238) at the second rotational speed, the transmission being a planetary gear system or a continuously variable transmission.
A greenhouse (10, 50), comprising: a growing section (16, 56); an air or gas distribution system within said growing section (16, 56), said distribution system comprising one or more conduits (18, 58) for distributing air or gas within said greenhouse (10, 50), said conduits (18, 58) comprising an inner conduit (104, 204) within an outer conduit (102, 202), said conduits (18, 58) carrying air or gas having different pressures along their length, said inner conduit (104, 204) comprising inner conduit holes (108, 208) to allow a main airflow within said conduits (18, 58) to pass from within said inner conduit (104, 204), and said outer conduit (102, 202) comprising outer conduit holes (106, 206) that allow air passing from said inner conduit (104, 204) to pass into said growing section (16, 56), wherein said inner (108, 208) and outer (106, 206) conduit holes are offset such that each inner conduit hole (108, 208) is offset from each outer conduit hole (106, 206), such that said inner (108, 208) and outer (106, 206) conduit holes are configured to compensate for turbulence or pressure differences within said conduits (18, 58) to provide substantially equal distribution of air or gas throughout said growing section (16, 56). a growing section (16, 56); an air or gas distribution system within said growing section (16, 56), said distribution system comprising one or more conduits (18, 58) for distributing air or gas within said greenhouse (10, 50), said conduits (18, 58) comprising an inner conduit (104, 204) within an outer conduit (102, 202), said conduits (18, 58) carrying air or gas having different pressures along their length, said inner conduit (104, 204) comprising inner conduit holes (108, 208) to allow a main airflow within said conduits (18, 58) to pass from within said inner conduit (104, 204), and said outer conduit (102, 202) comprising outer conduit holes (106, 206) that allow air passing from said inner conduit (104, 204) to pass into said growing section (16, 56), wherein said inner (108, 208) and outer (106, 206) conduit holes are offset such that each inner conduit hole (108, 208) is offset from each outer conduit hole (106, 206), such that said inner (108, 208) and outer (106, 206) conduit holes are configured to compensate for turbulence or pressure differences within said conduits (18, 58) to provide substantially equal distribution of air or gas throughout said growing section (16, 56).
Prosthesis for complete ossicular replacement which, being envisaged to replace all the damaged ossicles of the middle ear, for the purpose of mitigating hypoacusia or hearing loss to a certain extent, having a member which extends at one of its ends, considered proximal, into a fork for anchorage thereof and, at the opposite end, into a base having progressively increasing width, characterised in that the member is a continuously arched member for anchorage thereof to the corresponding medial zone of the hammer handle underneath it without lifting the tympanic membrane, while the base establishes a larger surface area which is disposed in contact with the corresponding oval window on applying the prosthesis to the middle ear due to the continuously arched member.
Crystalline form of agomelatine, its X-ray diffraction diagram having the following values for interplanar crystal spacing d, Bragg angle 2θ and relative intensity: 2θ° d(Å) Relative intensity (I%) 10.557 8.3725 32.35 13.301 6.6509 11.45 16.145 5.4855 10.60 17.286 5.1258 6.19 17.841 4.9675 100.00 19.359 4.5813 10.83 20.089 4.4164 11.77 23.366 3.8040 29.82 24.944 3.5667 21.60 26.128 3.4078 12.47 including crystals whose peak diffraction angles are within 2θ±0.2° of the above.
A rotating machine, especially a decanter centrifuge, comprising: a bowl rotatable about an axis to generate a cylindrical pool of a feed slurry, said bowl having a heavy phase discharge port; and a base plate provided at one longitudinal end of said bowl; at least one outlet opening provided in said base plate; a liquid phase discharge port member (14, 22) placed over the at least one outlet opening; whereby said liquid phase discharge port member (14, 22) includes at least one open straight channel with a longitudinal axis; wherein the longitudinal axis of said channel extends at an acute angle (α) relative to said base plate and said channel has an extension in the direction of said longitudinal axis, characterised by an additional closed channel arranged radially outwardly with respect to said at least one channel having a longitudinal axis arranged parallel to said longitudinal axis of said at least one channel. a bowl rotatable about an axis to generate a cylindrical pool of a feed slurry, said bowl having a heavy phase discharge port; and a base plate provided at one longitudinal end of said bowl; at least one outlet opening provided in said base plate; a liquid phase discharge port member (14, 22) placed over the at least one outlet opening;
A top hung roof window, said window comprising: a frame comprising two side members, interconnected by a bottom member (2") and a top member (2"'), a sash comprising two side members, interconnected by a bottom member (3") and a top member (3"'), the sash being pivotally connected to the frame along said top members (2"', 3"') by a hinge for pivotal movement of the sash between a closed position and open positions, an elongated member provided at or in one of said side members of the frame and extending substantially parallel therewith, and a link mechanism operably connecting said sash to said elongated member so that said elongated member is longitudinally displaced when the sash pivots relative to the frame, said elongated member being resiliently biased for balancing the sash in any open position, characterized in that said window is provided with a linear actuator that comprises a static part and a linearly movable part, said static part is secured to said frame with said linearly movable part aligned with said elongated member and with an extremity of said linearly movable part permanently connected or releasably engaged with an opposing extremity of said elongated member, and in that said extremity of said linearly movable part is permanently connected with said opposing extremity of said elongated member, and wherein said linear actuator is not self-locking and thus movement of the sash forces movement of said linear actuator. a frame comprising two side members, interconnected by a bottom member (2") and a top member (2"'), a sash comprising two side members, interconnected by a bottom member (3") and a top member (3"'), the sash being pivotally connected to the frame along said top members (2"', 3"') by a hinge for pivotal movement of the sash between a closed position and open positions, an elongated member provided at or in one of said side members of the frame and extending substantially parallel therewith, and a link mechanism operably connecting said sash to said elongated member so that said elongated member is longitudinally displaced when the sash pivots relative to the frame, said elongated member being resiliently biased for balancing the sash in any open position, characterized in that said window is provided with a linear actuator that comprises a static part and a linearly movable part, said static part is secured to said frame with said linearly movable part aligned with said elongated member and with an extremity of said linearly movable part permanently connected or releasably engaged with an opposing extremity of said elongated member, and in that said extremity of said linearly movable part is permanently connected with said opposing extremity of said elongated member, and wherein said linear actuator is not self-locking and thus movement of the sash forces movement of said linear actuator.
A method of detecting an analyte of interest in a sample comprising: a. binding the analyte to: (i) a capture reagent on a surface, said surface comprising the capture reagent for the analyte, wherein the capture reagent is an antibody; (ii) a first detection reagent for the analyte that is linked to a first nucleic acid probe; and (iii) a second detection reagent for the analyte that is linked to a second nucleic acid probe, wherein the first detection reagent and the second detection reagent are antibodies; thereby forming a complex on the surface comprising the capture reagent, the analyte and the first and second detection reagents, wherein the surface also comprises an anchoring reagent comprising an anchoring oligonucleotide sequence; b. using an extension process that requires the first and second nucleic acid probes to be in proximity to one or two connector sequences that hybridize to the first and second nucleic acid probes, ligating the one or two connector sequences to form a circular template, and extending the second nucleic acid probe, by rolling circle amplification of the circular template, to form an extended sequence comprising an anchoring sequence complement that is complementary to the anchoring oligonucleotide sequence; c. hybridizing the anchoring oligonucleotide sequence to the anchoring sequence complement of the extended sequence; and d. measuring the amount of extended sequence bound to the surface. a. binding the analyte to: (i) a capture reagent on a surface, said surface comprising the capture reagent for the analyte, wherein the capture reagent is an antibody; (ii) a first detection reagent for the analyte that is linked to a first nucleic acid probe; and (iii) a second detection reagent for the analyte that is linked to a second nucleic acid probe, wherein the first detection reagent and the second detection reagent are antibodies; thereby forming a complex on the surface comprising the capture reagent, the analyte and the first and second detection reagents, wherein the surface also comprises an anchoring reagent comprising an anchoring oligonucleotide sequence; b. using an extension process that requires the first and second nucleic acid probes to be in proximity to one or two connector sequences that hybridize to the first and second nucleic acid probes, ligating the one or two connector sequences to form a circular template, and extending the second nucleic acid probe, by rolling circle amplification of the circular template, to form an extended sequence comprising an anchoring sequence complement that is complementary to the anchoring oligonucleotide sequence; c. hybridizing the anchoring oligonucleotide sequence to the anchoring sequence complement of the extended sequence; and d. measuring the amount of extended sequence bound to the surface.
A power distribution network comprising: a primary charging circuit; a first charge storage component having a first terminal connected to said primary charging circuit and a second terminal connected to a power supply common voltage; a second charge storage component having a first terminal, said second charge storage component having a second terminal connected to said power supply common voltage; a converter having an input terminal and an output terminal, said input terminal receiving an input voltage from said first terminal of said first charge storage component, and said output terminal supplying an output voltage, wherein a magnitude of said output voltage is altered relative to a magnitude of said input voltage; an electromagnetic interference filter having an input terminal and an output terminal, said input terminal of said electromagnetic interference filter receiving, from said output terminal of said converter, said output voltage and said output terminal of said electromagnetic interference filter supplying a filtered output voltage to said first terminal of said second charge storage component; and a power amplifier circuit connected to said first terminal of said second charge storage component, said power amplifier circuit designed according to a range of variation of said filtered output voltage. a primary charging circuit; a first charge storage component having a first terminal connected to said primary charging circuit and a second terminal connected to a power supply common voltage; a second charge storage component having a first terminal, said second charge storage component having a second terminal connected to said power supply common voltage; a converter having an input terminal and an output terminal, said input terminal receiving an input voltage from said first terminal of said first charge storage component, and said output terminal supplying an output voltage, wherein a magnitude of said output voltage is altered relative to a magnitude of said input voltage; an electromagnetic interference filter having an input terminal and an output terminal, said input terminal of said electromagnetic interference filter receiving, from said output terminal of said converter, said output voltage and said output terminal of said electromagnetic interference filter supplying a filtered output voltage to said first terminal of said second charge storage component; and a power amplifier circuit connected to said first terminal of said second charge storage component, said power amplifier circuit designed according to a range of variation of said filtered output voltage.
A fastening construction for fastening an adjustment instrument to a carrying frame of an exterior vision unit of a motor vehicle, the carrying frame being arranged for connection with a base shaft of a base of the exterior vision unit, and the adjustment instrument including a fixing part arranged for coupling with the carrying frame, and an adjusting part arranged for coupling with an exterior vision element of the exterior vision unit, the fastening construction is arranged between the carrying frame and the adjustment instrument and comprising first mounting parts on a fixing part of the adjustment instrument and second mounting parts on the carrying frame, wherein the first and second mounting parts (10, 12) comprise blocking parts (13A, 13B) on the fixing part and the carrying frame respectively, which in a first position can pass each other upon insertion of the parts (13A, 13B) into each other in an insert direction, and which by movement in a plane transverse to the insert direction are brought to a second position in which the blocking parts (13A, 13B) cooperate and cannot pass each other upon movement opposite to the insert direction, characterized in that there is provided a spring part which in mounted condition biases the first and second mounting parts (10, 12) against each other.
A support device, comprising: a support bracket for supporting a formwork element and/or a working platform of a formwork, the support bracket comprising: a horizontal beam having a first longitudinal end for fastening to a supporting element, in particular to a vertical beam, for the formwork and having a second longitudinal end, a first adjusting device for vertical adjustment of the horizontal beam relative to the supporting element, the support device further comprising the supporting element, preferably the vertical beam, the first longitudinal end of the horizontal beam of the support bracket being fastened to the supporting element of the formwork, characterized in that the first adjusting device comprises a slotted guide system having a guide slot extending obliquely to the horizontal beam, in which guide slot a guide pin of the support device is guided, the first adjusting device comprising a first force transmission element, by means of which a force can be applied substantially in the longitudinal direction of the horizontal beam to the slotted guide system, the guide slot being formed on a sliding part which, when the first force transmission element is adjusted, is displaced substantially in the longitudinal direction, of the horizontal beam within a mounting case at the first longitudinal end of the horizontal beam. a horizontal beam having a first longitudinal end for fastening to a supporting element, in particular to a vertical beam, for the formwork and having a second longitudinal end, a first adjusting device for vertical adjustment of the horizontal beam relative to the supporting element, the support device further comprising the supporting element, preferably the vertical beam, the first longitudinal end of the horizontal beam of the support bracket being fastened to the supporting element of the formwork, characterized in that the first adjusting device comprises a slotted guide system having a guide slot extending obliquely to the horizontal beam, in which guide slot a guide pin of the support device is guided, the first adjusting device comprising a first force transmission element, by means of which a force can be applied substantially in the longitudinal direction of the horizontal beam to the slotted guide system, the guide slot being formed on a sliding part which, when the first force transmission element is adjusted, is displaced substantially in the longitudinal direction, of the horizontal beam within a mounting case at the first longitudinal end of the horizontal beam.
A compound represented by formula wherein R E1 and R E2 are independently selected from C 1-6 alkoxy and hydroxy and are attached meta and para compared to the carbon atom which binds the phenyl ring to ring D; X, Y, M, Z and L are defined, so that the ring D is directionally selected from the following structures: wherein R 8 and R 9 are selected from hydrogen; C 1-4 alkyl; -C 1-4 alkylene-halogen; and C 6-10 aryl, wherein the aryl ring can be optionally substituted by C 1-4 alkyl or halogen; Hal is selected from F, Cl, Br, and I; R E3 is a C 1-6 alkyl group or a C 5-10 aryl group; m is 0 to 2; R E4 is a halogen atom, a C 1-6 alkyl group or a C 5-10 aryl group; p is 0 or 1; as well as an ester, solvate or salt of the compound represented by formula. R E1 and R E2 are independently selected from C 1-6 alkoxy and hydroxy and are attached meta and para compared to the carbon atom which binds the phenyl ring to ring D; X, Y, M, Z and L are defined, so that the ring D is directionally selected from the following structures: wherein R 8 and R 9 are selected from hydrogen; C 1-4 alkyl; -C 1-4 alkylene-halogen; and C 6-10 aryl, wherein the aryl ring can be optionally substituted by C 1-4 alkyl or halogen; Hal is selected from F, Cl, Br, and I; R E3 is a C 1-6 alkyl group or a C 5-10 aryl group; m is 0 to 2; R E4 is a halogen atom, a C 1-6 alkyl group or a C 5-10 aryl group; p is 0 or 1; R 8 and R 9 are selected from hydrogen; C 1-4 alkyl; -C 1-4 alkylene-halogen; and C 6-10 aryl, wherein the aryl ring can be optionally substituted by C 1-4 alkyl or halogen; Hal is selected from F, Cl, Br, and I; R E3 is a C 1-6 alkyl group or a C 5-10 aryl group; m is 0 to 2; R E4 is a halogen atom, a C 1-6 alkyl group or a C 5-10 aryl group; p is 0 or 1;