A method of determining, by electrical impedance myography, at least one first characteristic of a region of tissue, the method comprising: measuring the electrode contact quality of a first and second plurality of electrodes; automatically reconfiguring the first and second plurality of electrodes based on the measured electrode contact quality to exclude one or more electrodes from the first and second plurality of electrodes; selecting at least one first pair of the first plurality of electrodes to apply a first electrical signal comprising a plurality of frequencies to the region of tissue, the electrodes of the at least one first pair being in a first orientation with respect to the muscle fibers; detecting at least one value of at least one second characteristic of the region of tissue during a time when the first electrical signal is applied to the region of tissue; selecting at least one second pair of the second plurality of electrodes to detect a second electrical signal at the region of tissue resulting from the application of the first electrical signal by the at least one first pair, the electrodes of the at least one second pair being in the first orientation, wherein the first plurality of electrodes is reconfigurable to select at least one third pair of the first plurality of electrodes to apply the first electrical signal to the region of tissue, the electrodes of the at least one third pair being in a second orientation with respect to the muscle fibers; and the second plurality of electrodes is reconfigurable to select at least one fourth pair of the second plurality of electrodes to detect the second electrical signal at the region of tissue resulting from the application of the first electrical signal by the at least one third pair, the electrodes of the at least one fourth pair being in the second orientation; and adjusting the second electrical signal based on the at least one value of the at least one second characteristic. measuring the electrode contact quality of a first and second plurality of electrodes; automatically reconfiguring the first and second plurality of electrodes based on the measured electrode contact quality to exclude one or more electrodes from the first and second plurality of electrodes; selecting at least one first pair of the first plurality of electrodes to apply a first electrical signal comprising a plurality of frequencies to the region of tissue, the electrodes of the at least one first pair being in a first orientation with respect to the muscle fibers; detecting at least one value of at least one second characteristic of the region of tissue during a time when the first electrical signal is applied to the region of tissue; selecting at least one second pair of the second plurality of electrodes to detect a second electrical signal at the region of tissue resulting from the application of the first electrical signal by the at least one first pair, the electrodes of the at least one second pair being in the first orientation, wherein the first plurality of electrodes is reconfigurable to select at least one third pair of the first plurality of electrodes to apply the first electrical signal to the region of tissue, the electrodes of the at least one third pair being in a second orientation with respect to the muscle fibers; and the second plurality of electrodes is reconfigurable to select at least one fourth pair of the second plurality of electrodes to detect the second electrical signal at the region of tissue resulting from the application of the first electrical signal by the at least one third pair, the electrodes of the at least one fourth pair being in the second orientation; and adjusting the second electrical signal based on the at least one value of the at least one second characteristic.