A body support system for support of a person's body in a supine position, the body having a torso, the body support system, comprising: at least one uppermost comfort layer having a support surface and disposed above a central core of the body support system, the at least one uppermost comfort layer comprising a temperature and pressure sensitive cellular polymer material, the central core being an area positioned between the at least one uppermost comfort layer and a bottommost layer of the body support system; an air flow guide disposed within the central core of the body support system, the air flow guide comprising a central body portion, a lower body portion, and an upper body portion, said central body portion, lower body portion and upper body portion being positioned within the body support system at a location corresponding to the location intended to support a person's central body, lower body and upper body, respectively, wherein the upper body portion of the air flow guide is positioned vertically higher relative to the lower body portion of the air flow guide, wherein the air flow guide is manufactured from a low air loss material, and wherein the air flow guide forms a discrete air flow path to direct air and/or moisture vapor flow through the central core of the body support system; a plurality of support layers positioned under the air flow guide, the plurality of support layers including an upper support layer, a central support layer, a lower support layer, and a foundation support layer, wherein the foundation support layer is the bottommost layer of the body support system, and wherein the central support layer has a density range from about 22,43 kg/m 3 to about 32,04 kg/m 3, and the lower support layer has a density range from about 16,02 kg/m 3 to about 20,82 kg/m 3; and at least one air flow unit, disposed within an internal portion of the body support system, wherein during operation, the at least one air flow unit facilitates withdrawal from and removal of moisture and heat at the foam support surface such that the at least one air flow unit operates to reduce and/or increase pressure within the body support system to facilitate air flow along the air flow path from an air inlet to an air outlet disposed within the body support system in a central core positioned below, and adjacent to, the at least one uppermost comfort layer. at least one uppermost comfort layer having a support surface and disposed above a central core of the body support system, the at least one uppermost comfort layer comprising a temperature and pressure sensitive cellular polymer material, the central core being an area positioned between the at least one uppermost comfort layer and a bottommost layer of the body support system; an air flow guide disposed within the central core of the body support system, the air flow guide comprising a central body portion, a lower body portion, and an upper body portion, said central body portion, lower body portion and upper body portion being positioned within the body support system at a location corresponding to the location intended to support a person's central body, lower body and upper body, respectively, wherein the upper body portion of the air flow guide is positioned vertically higher relative to the lower body portion of the air flow guide, wherein the air flow guide is manufactured from a low air loss material, and wherein the air flow guide forms a discrete air flow path to direct air and/or moisture vapor flow through the central core of the body support system; a plurality of support layers positioned under the air flow guide, the plurality of support layers including an upper support layer, a central support layer, a lower support layer, and a foundation support layer, wherein the foundation support layer is the bottommost layer of the body support system, and wherein the central support layer has a density range from about 22,43 kg/m 3 to about 32,04 kg/m 3, and the lower support layer has a density range from about 16,02 kg/m 3 to about 20,82 kg/m 3; and at least one air flow unit, disposed within an internal portion of the body support system, wherein during operation, the at least one air flow unit facilitates withdrawal from and removal of moisture and heat at the foam support surface such that the at least one air flow unit operates to reduce and/or increase pressure within the body support system to facilitate air flow along the air flow path from an air inlet to an air outlet disposed within the body support system in a central core positioned below, and adjacent to, the at least one uppermost comfort layer.