A computer-implemented method of controlling image segmentation, using at least one computer system, the method comprising using a processor for: receiving, at the at least one computer system, a digital representation of image data; and generating, by the at least one computer system, a set of image segmentation candidates; the method using the processor for: generating, by the at least one computer system, a set of alternative segmentation candidates by perturbing the input image by rigid transformation and the addition of Gaussian noise to voxels of the image; determining, by the at least one computer system, one or more associations between members of said set of alternative image segmentation candidates; generating one or more groups of members, each group comprising one or more image segmentation candidates among the generated alternative image segmentation candidates, based on the one or more associations, determined in said determining, between the alternative image segmentation candidates of the group; determining, by the at least one computer system, a representative segmentation for each group; presenting, by the at least one computer system, the representative segmentation of each group of the one or more groups for selection by a user; and recording the selection and saving the one or more selected representative segmentations in memory. receiving, at the at least one computer system, a digital representation of image data; and generating, by the at least one computer system, a set of image segmentation candidates; the method using the processor for: generating, by the at least one computer system, a set of alternative segmentation candidates by perturbing the input image by rigid transformation and the addition of Gaussian noise to voxels of the image; determining, by the at least one computer system, one or more associations between members of said set of alternative image segmentation candidates; generating one or more groups of members, each group comprising one or more image segmentation candidates among the generated alternative image segmentation candidates, based on the one or more associations, determined in said determining, between the alternative image segmentation candidates of the group; determining, by the at least one computer system, a representative segmentation for each group; presenting, by the at least one computer system, the representative segmentation of each group of the one or more groups for selection by a user; and recording the selection and saving the one or more selected representative segmentations in memory. generating, by the at least one computer system, a set of alternative segmentation candidates by perturbing the input image by rigid transformation and the addition of Gaussian noise to voxels of the image; determining, by the at least one computer system, one or more associations between members of said set of alternative image segmentation candidates; generating one or more groups of members, each group comprising one or more image segmentation candidates among the generated alternative image segmentation candidates, based on the one or more associations, determined in said determining, between the alternative image segmentation candidates of the group; determining, by the at least one computer system, a representative segmentation for each group; presenting, by the at least one computer system, the representative segmentation of each group of the one or more groups for selection by a user; and recording the selection and saving the one or more selected representative segmentations in memory.