Method for selecting a compound for the prevention or the treatment of cancer, said cancer to be prevented or treated being selected from the group consisting of breast cancer, lung cancer, neuroblastoma, glioma, leukemia, sarcoma, melanoma and adenocarcinoma, wherein said cancer to be prevented or treated is a cancer wherein tumoral cells express or overexpress netrin-1, wherein said method comprises the following steps of: a) having a medium containing netrin-1, or a fragment thereof, and a netrin-1 receptor, or a fragment thereof, wherein: - said netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, is able to specifically interact together to form a binding pair, and/or - said netrin-1, or a fragment thereof, is able to induce the dimerization or multimerization of the intracellular domain of said netrin-1 receptor; b) contacting said medium with the compound to be tested; c) - measuring the inhibition of the interaction between netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, and/or - determining whether said compound inhibits the dimerization or multimerization of said netrin-1 receptor, or a fragment thereof, particularly the dimerization of the intracellular domain of said netrin-1 receptor; and d) selecting said compound if: - the measuring in step c) demonstrates a significant inhibition of the interaction between netrin-1, or a fragment thereof, and netrin-1 receptor, or a fragment thereof, in presence of said compound, and/or - the determination in step c) demonstrates a significant inhibition of the dimerization or multimerization, in presence of said compound, of the intracellular domain of said netrin-1 receptor. a) having a medium containing netrin-1, or a fragment thereof, and a netrin-1 receptor, or a fragment thereof, wherein: - said netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, is able to specifically interact together to form a binding pair, and/or - said netrin-1, or a fragment thereof, is able to induce the dimerization or multimerization of the intracellular domain of said netrin-1 receptor; - said netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, is able to specifically interact together to form a binding pair, and/or - said netrin-1, or a fragment thereof, is able to induce the dimerization or multimerization of the intracellular domain of said netrin-1 receptor; b) contacting said medium with the compound to be tested; c) - measuring the inhibition of the interaction between netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, and/or - determining whether said compound inhibits the dimerization or multimerization of said netrin-1 receptor, or a fragment thereof, particularly the dimerization of the intracellular domain of said netrin-1 receptor; and - measuring the inhibition of the interaction between netrin-1, or a fragment thereof, and said netrin-1 receptor, or a fragment thereof, and/or - determining whether said compound inhibits the dimerization or multimerization of said netrin-1 receptor, or a fragment thereof, particularly the dimerization of the intracellular domain of said netrin-1 receptor; and d) selecting said compound if: - the measuring in step c) demonstrates a significant inhibition of the interaction between netrin-1, or a fragment thereof, and netrin-1 receptor, or a fragment thereof, in presence of said compound, and/or - the determination in step c) demonstrates a significant inhibition of the dimerization or multimerization, in presence of said compound, of the intracellular domain of said netrin-1 receptor. - the measuring in step c) demonstrates a significant inhibition of the interaction between netrin-1, or a fragment thereof, and netrin-1 receptor, or a fragment thereof, in presence of said compound, and/or - the determination in step c) demonstrates a significant inhibition of the dimerization or multimerization, in presence of said compound, of the intracellular domain of said netrin-1 receptor.