mhurhangee/ep-ind-claims huggingface dataset:
Substituted 1,4-dioxa-8-azaspiro[4,5]decane compounds represented by: 2-(4-bromo-2-chlorophenoxy)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(morpholin-4-yl)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(2-chloro-5-thiazolyl)methoxymethyl-8-phenethyl-1,4-dioxa-8 azaspiro[4,5]decane; 2-benzyloxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 8-phenethyl-2-pheny]sulphanylmethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(benzotriazol-1-yl)methy]-8-(4,6-dimethoxy-pyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4,5]decane and N-(5-chloro-2-fluorophenyl)-N-[8-[(2-chloro-5-thiazolyl)methyl]-1,4-dioxa-8-azaspiro[4,5]dec-2-yl] methanamine 2-(4-bromo-2-chlorophenoxy)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(morpholin-4-yl)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(2-chloro-5-thiazolyl)methoxymethyl-8-phenethyl-1,4-dioxa-8 azaspiro[4,5]decane; 2-benzyloxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane; 8-phenethyl-2-pheny]sulphanylmethyl-1,4-dioxa-8-azaspiro[4,5]decane; 2-(benzotriazol-1-yl)methy]-8-(4,6-dimethoxy-pyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4,5]decane and N-(5-chloro-2-fluorophenyl)-N-[8-[(2-chloro-5-thiazolyl)methyl]-1,4-dioxa-8-azaspiro[4,5]dec-2-yl] methanamine
A covering device for covering the lips and labial angles and for holding the lips, cheeks and labial angles away from the rows of teeth in the mouth of a patient, comprising an elastic lip clamping element (110, 210, 310), at least one elastic vestibular clamping element (120, 220, 320) and a film (130, 230, 330) connecting the clamping elements, wherein the clamping elements are arranged along two opposite end regions of the film, wherein the clamping elements (110, 210, 310; 120, 220, 320) are elastically deformable and span the film (130, 230, 330) in a relaxed state, wherein the vestibular clamping element (120, 220, 320) comprises at least one section (121, 221, 321) curved toward the lip clamping element, which extends anterior to the vestibular fold when the covering device is inserted, characterized in that the film (130, 230, 330) is shortened in the center of the curved section (121, 221, 321) to 30 to 70 percent compared to the remaining regions.
A method of transfecting a primary hematopoietic cell with nucleic acids, at least one which encodes for a rare-cutting endonuclease, to be expressed into said cell or to be introduced into its genome, said method comprising the steps of: a) isolating hematopoietic cells; b) culturing the hematopoietic cells in a condition where they can expand; c) loading nanoparticle-biomolecule conjugates with nucleic acids, at least one which encodes a rare-cutting endonuclease, to be expressed into said cell or to be introduced into its genome; d) incubating said hematopoietic cells with said nanoparticle-biomolecule conjugates to have them penetrate the cells; wherein said nanoparticle-biomolecule conjugates are silica-based nanoparticles which are coated with cell penetrating peptides (CPPs) and/or ligand targeting molecule. a) isolating hematopoietic cells; b) culturing the hematopoietic cells in a condition where they can expand; c) loading nanoparticle-biomolecule conjugates with nucleic acids, at least one which encodes a rare-cutting endonuclease, to be expressed into said cell or to be introduced into its genome; d) incubating said hematopoietic cells with said nanoparticle-biomolecule conjugates to have them penetrate the cells;
A method of performing a random access procedure over a radio interface served by a radio base station (104, 140), the method comprising the steps of: - selecting an access time slot for transmission of an access burst over the radio interface; and - setting an access bandwidth (BW RACH) for transmission of the access burst; wherein an available transmission bandwidth supported by the radio base station for uplink transmissions conforms to a predefined maximum transmission bandwidth conforming to a communication standard or a portion thereof, wherein the access bandwidth is set smaller than said available transmission bandwidth characterised in that the access bandwidth is selected according to an access frequency band having the access bandwidth within the available transmission bandwidth and that the access frequency band is selected according to a frequency hopping pattern associated with the radio interface. - selecting an access time slot for transmission of an access burst over the radio interface; and - setting an access bandwidth (BW RACH) for transmission of the access burst;
Microfluidic droplet-based assay process for analyzing biological cell activity by detection of at least one target analyte contained in one or several droplets, wherein the process comprises the step of creating several assay droplets of a liquid culture medium where an assay droplet contains: - paramagnetic particles ( 22, 22 '); - detectable markers; - and, at least one biological cell potentially capable of releasing at least one target analyte; wherein the paramagnetic particles ( 22, 22 ') and the detectable markers are able to bind with a target analyte to form a marked and magnetized combination with a target analyte, wherein the process includes storing several assay droplets along a single layer along a horizontal storage plane, wherein the process includes the generation of a magnetic field through the stored assay droplets for spatially arranging the paramagnetic particles inside the stored assay droplets, and wherein the process includes detecting, within a given stored assay droplet, a physical characteristic of the detectable markers contained in the given assay droplet, by optical imaging of the detectable markers, characterized in that the generation of a magnetic field generates a magnetic field such that the paramagnetic particles are attracted towards a lateral and inferior portion of the given stored assay droplet in which they are contained. - paramagnetic particles ( 22, 22 '); - detectable markers; - and, at least one biological cell potentially capable of releasing at least one target analyte; wherein the paramagnetic particles ( 22, 22 ') and the detectable markers are able to bind with a target analyte to form a marked and magnetized combination with a target analyte,
A method of controlling a load wrapping apparatus of the type configured to wrap a load on a load support with packaging material dispensed from a packaging material dispenser through relative rotation between the packaging material dispenser and the load support, the method comprising: determining a containment force parameter associated with a desired containment force to be applied to the load during at least a portion of a wrap cycle; initiating the wrap cycle to wrap the load with packaging material dispensed from the packaging material dispenser during relative rotation between the packaging material dispenser and the load support; and during the initiated wrap cycle: monitoring a wrap force applied to the load by the packaging material during the relative rotation; performing a comparison between the monitored wrap force and the containment force parameter after a conversion between wrap force and containment force is performed for the monitored wrap force or the containment force parameter; characterized in that the method further comprises: dynamically controlling a dispense rate of the packaging material dispenser during the wrap cycle based on the comparison between the monitored wrap force and the containment force parameter. determining a containment force parameter associated with a desired containment force to be applied to the load during at least a portion of a wrap cycle; initiating the wrap cycle to wrap the load with packaging material dispensed from the packaging material dispenser during relative rotation between the packaging material dispenser and the load support; and during the initiated wrap cycle: monitoring a wrap force applied to the load by the packaging material during the relative rotation; performing a comparison between the monitored wrap force and the containment force parameter after a conversion between wrap force and containment force is performed for the monitored wrap force or the containment force parameter; characterized in that the method further comprises: dynamically controlling a dispense rate of the packaging material dispenser during the wrap cycle based on the comparison between the monitored wrap force and the containment force parameter. monitoring a wrap force applied to the load by the packaging material during the relative rotation; performing a comparison between the monitored wrap force and the containment force parameter after a conversion between wrap force and containment force is performed for the monitored wrap force or the containment force parameter; characterized in that the method further comprises: dynamically controlling a dispense rate of the packaging material dispenser during the wrap cycle based on the comparison between the monitored wrap force and the containment force parameter.
A method of determining a geographic position of a sending device using a communications channel between a receiving device and the sending device, the sending device being nearby the receiving device, the method comprising: receiving, at the receiving device from the sending device over the communications channel, a message containing delta position data for the sending device from which a delta position can be determined and a hashed message authentication code; determining a coordinate position of the receiving device and quantizing the coordinate position of the receiving device to obtain a receiving device quantized coordinate position; determining a set of candidate quantized coordinate positions based on the receiving device quantized coordinate position; disambiguating between the candidate quantized coordinate positions for the sending device to identify a sending device quantized coordinate position used by the sending device to determine the delta position data by hashing strings, each string including a respective candidate quantized coordinate position and determining which of the hashed strings corresponds to the hashed message authentication code, wherein the corresponding hashed string includes the sending device quantized coordinate position; determining a coordinate position of the sending device by adding the delta position to the identified sending device quantized coordinate position; and causing an action based on the determined coordinate position of the sending device. receiving, at the receiving device from the sending device over the communications channel, a message containing delta position data for the sending device from which a delta position can be determined and a hashed message authentication code; determining a coordinate position of the receiving device and quantizing the coordinate position of the receiving device to obtain a receiving device quantized coordinate position; determining a set of candidate quantized coordinate positions based on the receiving device quantized coordinate position; disambiguating between the candidate quantized coordinate positions for the sending device to identify a sending device quantized coordinate position used by the sending device to determine the delta position data by hashing strings, each string including a respective candidate quantized coordinate position and determining which of the hashed strings corresponds to the hashed message authentication code, wherein the corresponding hashed string includes the sending device quantized coordinate position; determining a coordinate position of the sending device by adding the delta position to the identified sending device quantized coordinate position; and causing an action based on the determined coordinate position of the sending device.
A stable aqueous pharmaceutical formulation, comprising: (a) a monoclonal antibody in an amount of 25 mg/mL to 100 mg/mL, 35 mg/mL to 85 mg/mL, 45 mg/mL to 55 mg/mL, or 50 mg/mL; (b) trehalose in an amount of 45 mM to 634 mM, 45 mM to 135 mM, 180 mM to 634 mM, or 60 mM; and (c) sodium phosphate in an amount of 35 mM to 100 mM, 45 mM to 90 mM, 50 mM to 75 mM, or 51 mM; wherein said formulation has a pH of 5.5 to 7.0, 5.9 to 6.5, 6.2, or 6.0; wherein the weight ratio of said monoclonal antibody to said trehalose in the formulation is 0.49 to 1.47, 0.49 to 0.73, or 0.73 to 1.47, wherein the weight ratio of said monoclonal antibody to said trehalose in the formulation is not 0.83, wherein said formulation is stable when stored at -20°C or -40°C for at least 6 months, wherein the monoclonal antibody is bevacizumab, and wherein the weight of trehalose in the formulation for calculating the weight ratio of the antibody to the trehalose is based on the MW of trehalose dihydrate, wherein the MW is 378.33. (a) a monoclonal antibody in an amount of 25 mg/mL to 100 mg/mL, 35 mg/mL to 85 mg/mL, 45 mg/mL to 55 mg/mL, or 50 mg/mL; (b) trehalose in an amount of 45 mM to 634 mM, 45 mM to 135 mM, 180 mM to 634 mM, or 60 mM; and (c) sodium phosphate in an amount of 35 mM to 100 mM, 45 mM to 90 mM, 50 mM to 75 mM, or 51 mM; wherein said formulation has a pH of 5.5 to 7.0, 5.9 to 6.5, 6.2, or 6.0; wherein the weight ratio of said monoclonal antibody to said trehalose in the formulation is 0.49 to 1.47, 0.49 to 0.73, or 0.73 to 1.47, wherein the weight ratio of said monoclonal antibody to said trehalose in the formulation is not 0.83, wherein said formulation is stable when stored at -20°C or -40°C for at least 6 months, wherein the monoclonal antibody is bevacizumab, and wherein the weight of trehalose in the formulation for calculating the weight ratio of the antibody to the trehalose is based on the MW of trehalose dihydrate, wherein the MW is 378.33.
A product for producing a tissue adhesive, said product having an adhesive component and a curative component, wherein said adhesive component comprises an aqueous solution of a hydrophobically modified fish-derived gelatin having a hydrophobic group on a side chain thereof, and wherein said curative component comprises an aqueous solution of a water-soluble crosslinking reagent, said water-soluble crosslinking reagent being pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate (known as 4S-PEG), wherein a tissue adhesive to be applied to a tissue is formable by mixing said components; and wherein each of the aqueous solution of a hydrophobically modified fish-derived gelatin and the aqueous solution of 4S-PEG are phosphate buffer solutions having a pH of from 6.0 to 8.0.
A method for forming a cell array comprising a plurality of discrete cell samples on a single substrate, the method comprising the steps of: (a) mixing a cell suspension in a source to obtain a substantially uniform distribution of the cells within the suspension; (b) aspirating the cell suspension from the source; (c) movably transporting the cell suspension relative to the substrate; (d) metering a predetermined amount of the cell suspension using a positive displacement pump; (e) dispensing the metered amount of the cell suspension in the form of droplets onto the substrate so as to form a plurality of discrete cell samples, wherein cell density in the cell suspension is adjusted by diluting the cells prior to dispensing onto the substrate such that the average distance between the cells of each discrete cell sample is about 50 to 100 μm to provide a monolayer distribution of cells on the substrate; and (f) relatively uniformly dispersing the cells on the substrate with sufficiently low minimal overlap between the cells of each discrete cell sample, wherein the distance between the discrete cell samples and drop volume are selected such that the outer perimeter of each discrete cell sample is spaced from or contiguous with the perimeter of an adjoining discrete sample. (a) mixing a cell suspension in a source to obtain a substantially uniform distribution of the cells within the suspension; (b) aspirating the cell suspension from the source; (c) movably transporting the cell suspension relative to the substrate; (d) metering a predetermined amount of the cell suspension using a positive displacement pump; (e) dispensing the metered amount of the cell suspension in the form of droplets onto the substrate so as to form a plurality of discrete cell samples, wherein cell density in the cell suspension is adjusted by diluting the cells prior to dispensing onto the substrate such that the average distance between the cells of each discrete cell sample is about 50 to 100 μm to provide a monolayer distribution of cells on the substrate; and (f) relatively uniformly dispersing the cells on the substrate with sufficiently low minimal overlap between the cells of each discrete cell sample, wherein the distance between the discrete cell samples and drop volume are selected such that the outer perimeter of each discrete cell sample is spaced from or contiguous with the perimeter of an adjoining discrete sample.
A vacuum pump, in particular a Roots pump or a screw pump, comprising pump-active elements which can be driven to make a working movement and which transport a gas to be pumped from an inlet to an outlet of the vacuum pump, a vibration sensor which acquires vibration data of the vacuum pump on the basis of the working movement of the pump-active elements, and an evaluation unit which is configured to evaluate the vibration data, characterized in that the vibration sensor is integrated into a circuit board of the vacuum pump, with the circuit board being arranged in an inner space of the vacuum pump. pump-active elements which can be driven to make a working movement and which transport a gas to be pumped from an inlet to an outlet of the vacuum pump, a vibration sensor which acquires vibration data of the vacuum pump on the basis of the working movement of the pump-active elements, and an evaluation unit which is configured to evaluate the vibration data, characterized in that the vibration sensor is integrated into a circuit board of the vacuum pump, with the circuit board being arranged in an inner space of the vacuum pump.
A method for providing prompts in speech recognition results in real time, comprising: obtaining a current speech input in an audio stream for a target event; identifying a current utterance text corresponding to the current speech input; generating a prompt based at least on the current utterance text, the prompt comprising at least one predicted subsequent utterance text sequence; and providing a speech recognition result for the current speech input, the speech recognition result comprising the current utterance text and the prompt; wherein the generating the prompt comprises: predicting, through a previously-established prompt generator, the at least one predicted subsequent utterance text sequence based at least on the current utterance text; and the method further comprises: obtaining at least one document associated with the target event; and establishing the prompt generator based at least on the at least one document. obtaining a current speech input in an audio stream for a target event; identifying a current utterance text corresponding to the current speech input; generating a prompt based at least on the current utterance text, the prompt comprising at least one predicted subsequent utterance text sequence; and providing a speech recognition result for the current speech input, the speech recognition result comprising the current utterance text and the prompt; wherein the generating the prompt comprises: predicting, through a previously-established prompt generator, the at least one predicted subsequent utterance text sequence based at least on the current utterance text; and the method further comprises: obtaining at least one document associated with the target event; and establishing the prompt generator based at least on the at least one document. predicting, through a previously-established prompt generator, the at least one predicted subsequent utterance text sequence based at least on the current utterance text; and the method further comprises: obtaining at least one document associated with the target event; and establishing the prompt generator based at least on the at least one document.
A subsea pressure regulation system (200, 300) for barrier fluid configured to lubricate and protect a subsea fluid processing machine configured to process a process fluid in a subsea location, the pressure regulation system comprising: a housing (208, 308) configured for deployment at the subsea location; a moveable member (220, 320) disposed within the housing and configured to longitudinally translate within the housing, the member having at least first and second surfaces, the first surface and an inner portion of the housing defining a first volume (212, 312) and the second surface and an inner portion of the housing defining a second volume (214, 314), the first and second volumes being variable in size depending on the longitudinal position of the moveable member, the subsea pressure regulation system (200, 300) being characterised in that the first volume is configured to be filled with barrier fluid supplied directly from a barrier fluid supply and be in fluid communication with barrier fluid circulating in the fluid processing machine and the second volume configured to be pressure matched with the process fluid in the fluid processing machine; a biasing mechanism configured to maintain the fluid pressure of the barrier fluid circulating in the machine at a predetermined differential above the fluid pressure of the process fluid in the fluid processing machine at least in part by translation of the moveable member (220, 320); and a valve arranged to control fluid communication between the first volume and the barrier fluid circulating in the fluid processing machine. a housing (208, 308) configured for deployment at the subsea location; a moveable member (220, 320) disposed within the housing and configured to longitudinally translate within the housing, the member having at least first and second surfaces, the first surface and an inner portion of the housing defining a first volume (212, 312) and the second surface and an inner portion of the housing defining a second volume (214, 314), the first and second volumes being variable in size depending on the longitudinal position of the moveable member, the subsea pressure regulation system (200, 300) being characterised in that the first volume is configured to be filled with barrier fluid supplied directly from a barrier fluid supply and be in fluid communication with barrier fluid circulating in the fluid processing machine and the second volume configured to be pressure matched with the process fluid in the fluid processing machine; a biasing mechanism configured to maintain the fluid pressure of the barrier fluid circulating in the machine at a predetermined differential above the fluid pressure of the process fluid in the fluid processing machine at least in part by translation of the moveable member (220, 320); and a valve arranged to control fluid communication between the first volume and the barrier fluid circulating in the fluid processing machine.