A medical imaging device for providing an image representation supporting accurate positioning of an intervention device in a target anatomy in a vessel intervention procedure, the medical imaging device being adapted for: (i) acquiring an anatomy representation of a vessel region of interest comprising the target anatomy from an anatomy representation providing device; (ii) acquiring at least one angiogram X-ray image of the vessel region of interest with contrast agent injected into the vessel and acquiring at least one live fluoroscopy X-ray image of the vessel region of interest without contrast agent injected into the vessel from at least one X-ray image acquiring device; (iii) performing the following process steps: - registering the anatomy representation to the at least one angiogram X-ray image in order to provide an anatomy-angiogram-registration; - processing the at least one angiogram X-ray image and the at least one live fluoroscopy X-ray image in order to identify in each of the angiogram X-ray image and the live fluoroscopy X-ray image a radio-opaque device being arranged such as to be spatially correlated with the vessel region of interest; - registering the at least one angiogram X-ray image to the at least one live fluoroscopy X-ray image based on the identified radio-opaque device in order to provide an angiogram-fluoroscopy-registration; and - combining (GTC, RALC) the anatomy-angiogram-registration and the angiogram-fluoroscopy-registration in order to provide an anatomy-fluoroscopy-registration; (iv) outputting an image representation resulting from the anatomy-fluoroscopy-registration; wherein the radio-opaque device is at the same position within the vessel region of interest for both the angiogram X-ray image acquisition and the live fluoroscopy X-ray image acquisition; and wherein a locking of a radio-opaque device is provided, wherein the locking is provided in a location of the vessel region of interest that is spatially tightly connected to the target anatomy such that this locked radio-opaque device is moving in coherence with the target anatomy; and wherein the radio-opaque device is processed and identified in both the angiogram X-ray image and the live fluoroscopy images of the vessel region of interest in order to act as a mediator in the spatial registration of the anatomy representation and the live views. (i) acquiring an anatomy representation of a vessel region of interest comprising the target anatomy from an anatomy representation providing device; (ii) acquiring at least one angiogram X-ray image of the vessel region of interest with contrast agent injected into the vessel and acquiring at least one live fluoroscopy X-ray image of the vessel region of interest without contrast agent injected into the vessel from at least one X-ray image acquiring device; (iii) performing the following process steps: - registering the anatomy representation to the at least one angiogram X-ray image in order to provide an anatomy-angiogram-registration; - processing the at least one angiogram X-ray image and the at least one live fluoroscopy X-ray image in order to identify in each of the angiogram X-ray image and the live fluoroscopy X-ray image a radio-opaque device being arranged such as to be spatially correlated with the vessel region of interest; - registering the at least one angiogram X-ray image to the at least one live fluoroscopy X-ray image based on the identified radio-opaque device in order to provide an angiogram-fluoroscopy-registration; and - combining (GTC, RALC) the anatomy-angiogram-registration and the angiogram-fluoroscopy-registration in order to provide an anatomy-fluoroscopy-registration; - registering the anatomy representation to the at least one angiogram X-ray image in order to provide an anatomy-angiogram-registration; - processing the at least one angiogram X-ray image and the at least one live fluoroscopy X-ray image in order to identify in each of the angiogram X-ray image and the live fluoroscopy X-ray image a radio-opaque device being arranged such as to be spatially correlated with the vessel region of interest; - registering the at least one angiogram X-ray image to the at least one live fluoroscopy X-ray image based on the identified radio-opaque device in order to provide an angiogram-fluoroscopy-registration; and - combining (GTC, RALC) the anatomy-angiogram-registration and the angiogram-fluoroscopy-registration in order to provide an anatomy-fluoroscopy-registration; (iv) outputting an image representation resulting from the anatomy-fluoroscopy-registration;