A network for handling an uplink, UL, transmission, comprising: a storage device, for storing instructions of: configuring a discontinuous reception, DRX, operation to a communication device; transmitting a semi-persistent scheduling, SPS, UL grant on a control channel to the communication device, wherein the SPS UL grant indicates a UL frequency resource periodically allocated to the communication device for a plurality of UL transmissions; receiving at least one first repetition of a UL transmission from the communication device, wherein the at least one first repetition is transmitted by the communication device using a hybrid automatic repeat request, HARQ, process according to the SPS UL grant and a UL HARQ round trip time, RTT, timer is started by the communication device for the HARQ process in response to the UL transmission; and transmitting a dynamic scheduling UL grant to the communication device, when the UL HARQ RTT timer expires and the UL transmission is not successfully received, wherein the dynamic scheduling UL grant indicates the communication device to retransmit the first UL transmission; and a processing circuit, coupled to the storage device, configured to execute the instructions stored in the storage device. a storage device, for storing instructions of: configuring a discontinuous reception, DRX, operation to a communication device; transmitting a semi-persistent scheduling, SPS, UL grant on a control channel to the communication device, wherein the SPS UL grant indicates a UL frequency resource periodically allocated to the communication device for a plurality of UL transmissions; receiving at least one first repetition of a UL transmission from the communication device, wherein the at least one first repetition is transmitted by the communication device using a hybrid automatic repeat request, HARQ, process according to the SPS UL grant and a UL HARQ round trip time, RTT, timer is started by the communication device for the HARQ process in response to the UL transmission; and transmitting a dynamic scheduling UL grant to the communication device, when the UL HARQ RTT timer expires and the UL transmission is not successfully received, wherein the dynamic scheduling UL grant indicates the communication device to retransmit the first UL transmission; and configuring a discontinuous reception, DRX, operation to a communication device; transmitting a semi-persistent scheduling, SPS, UL grant on a control channel to the communication device, wherein the SPS UL grant indicates a UL frequency resource periodically allocated to the communication device for a plurality of UL transmissions; receiving at least one first repetition of a UL transmission from the communication device, wherein the at least one first repetition is transmitted by the communication device using a hybrid automatic repeat request, HARQ, process according to the SPS UL grant and a UL HARQ round trip time, RTT, timer is started by the communication device for the HARQ process in response to the UL transmission; and transmitting a dynamic scheduling UL grant to the communication device, when the UL HARQ RTT timer expires and the UL transmission is not successfully received, wherein the dynamic scheduling UL grant indicates the communication device to retransmit the first UL transmission; and a processing circuit, coupled to the storage device, configured to execute the instructions stored in the storage device.