A tissue suturing apparatus for use with an endoscope (114; 514; 1214; 1314; 1514), comprising - a tissue suturing device (110; 510) coupleable to a distal end of the endoscope (114; 514; 1214; 1314; 1514), the tissue suturing device (110; 510) comprising: a plurality of tissue supports (240; 340; 440; 540; 1440), wherein each of the plurality of tissue supports (240; 340; 440; 540; 1440) is deployable towards a target tissue (122; 422; 522; 822; 922; 1222; 1322; 1422; 1522), and wherein one or more tissue supports (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) is configured to receive a suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521) during deployment, and a needle (120; 420; 520; 1220; 1320; 1520), wherein the needle (120; 420; 520; 1220; 1320; 1520) engages a tissue support (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) to deploy the tissue support (240; 340; 440; 540; 1440); and - a deployment device (135; 235; 335; 435; 535), wherein the plurality of tissue supports (240; 340; 440; 540; 1440) is contained within the deployment device (135; 235; 335; 435; 535) prior to deployment, the deployment device (135; 235; 335; 435; 535) comprising: a housing (238; 338; 438) containing the plurality of tissue supports (240; 340; 440; 540; 1440); and a cover extending across the housing (238; 338; 438), the cover including an opening to permit access to the plurality of tissue supports (240; 340; 440; 540; 1440) by the needle (120; 420; 520; 1220; 1320; 1520) when attached to the suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521). - a tissue suturing device (110; 510) coupleable to a distal end of the endoscope (114; 514; 1214; 1314; 1514), the tissue suturing device (110; 510) comprising: a plurality of tissue supports (240; 340; 440; 540; 1440), wherein each of the plurality of tissue supports (240; 340; 440; 540; 1440) is deployable towards a target tissue (122; 422; 522; 822; 922; 1222; 1322; 1422; 1522), and wherein one or more tissue supports (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) is configured to receive a suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521) during deployment, and a needle (120; 420; 520; 1220; 1320; 1520), wherein the needle (120; 420; 520; 1220; 1320; 1520) engages a tissue support (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) to deploy the tissue support (240; 340; 440; 540; 1440); and a plurality of tissue supports (240; 340; 440; 540; 1440), wherein each of the plurality of tissue supports (240; 340; 440; 540; 1440) is deployable towards a target tissue (122; 422; 522; 822; 922; 1222; 1322; 1422; 1522), and wherein one or more tissue supports (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) is configured to receive a suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521) during deployment, and a needle (120; 420; 520; 1220; 1320; 1520), wherein the needle (120; 420; 520; 1220; 1320; 1520) engages a tissue support (240; 340; 440; 540; 1440) of the plurality of tissue supports (240; 340; 440; 540; 1440) to deploy the tissue support (240; 340; 440; 540; 1440); and - a deployment device (135; 235; 335; 435; 535), wherein the plurality of tissue supports (240; 340; 440; 540; 1440) is contained within the deployment device (135; 235; 335; 435; 535) prior to deployment, the deployment device (135; 235; 335; 435; 535) comprising: a housing (238; 338; 438) containing the plurality of tissue supports (240; 340; 440; 540; 1440); and a cover extending across the housing (238; 338; 438), the cover including an opening to permit access to the plurality of tissue supports (240; 340; 440; 540; 1440) by the needle (120; 420; 520; 1220; 1320; 1520) when attached to the suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521). a housing (238; 338; 438) containing the plurality of tissue supports (240; 340; 440; 540; 1440); and a cover extending across the housing (238; 338; 438), the cover including an opening to permit access to the plurality of tissue supports (240; 340; 440; 540; 1440) by the needle (120; 420; 520; 1220; 1320; 1520) when attached to the suture (421; 521; 821; 921; 1021; 1121; 1221; 1321; 1421; 1521).