A compound of Formula: or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: X is independently CH 2 O or OCH 2; L 1 is independently a hydrocarbon linker substituted with 0-2 R c, a hydrocarbon-heteroatom linker substituted with 0-2 R c, or - 0-1 -(CH 2) 1-3 -(C 3-4 cycloalkyl substituted with 0-2 R c)-(CH 2) 0-2 -; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, CO, S p, NH, N(C 1-4 alkyl), CONH, NHCO and NHCO 2; R 1 is independently selected from: C 6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein said carbocycle and heterocycle are substituted with 0-4 R 3 and 0-1 R 4; R 2 independently selected from: OH, CO 2 H, -CONH(C 1-4 alkyl), -CONHOH, -CONHSO 2 R e, and -CONH-(CH 2) 0-3 -(5-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p); R 3, at each occurrence, is independently selected from: halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, C 1-6 haloalkoxy, C 1-4 haloalkylthio, and NO 2; R 4 is independently -L 2 -R 5; L 2 is independently selected from: a bond, O, S, CH 2, C(=O), and -OSO 2; R 5 is independently selected from: C 1-6 alkyl, C 2-6 alkenyl, C 1-6 haloalkyl, -(CH 2) n -C 3-6 carbocycle and a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein each ring moiety is substituted with 0-4 R a; R a, at each occurrence, is independently selected from: OH, CN, halogen, C 1-4 alkyl substituted with 0-1 OH, C 1-4 alkoxy, and C 1-4 haloalkyl; R b, at each occurrence, is independently selected from: H, alkyl, and -(CH 2) 0-2 -(phenyl substituted with 0-3 R d); R c, at each occurrence, is independently selected from: halogen, OH, Alkyl, C 1-4 haloalkyl, and C 1-4 alkoxy; R d, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R e is independently selected from: C 1-4 alkyl and phenyl; p is, independently at each occurrence, selected from 0, 1, and 2; and n is, independently at each occurrence, selected from 0, 1, and 2. X is independently CH 2 O or OCH 2; L 1 is independently a hydrocarbon linker substituted with 0-2 R c, a hydrocarbon-heteroatom linker substituted with 0-2 R c, or - 0-1 -(CH 2) 1-3 -(C 3-4 cycloalkyl substituted with 0-2 R c)-(CH 2) 0-2 -; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched, saturated or unsaturated; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, CO, S p, NH, N(C 1-4 alkyl), CONH, NHCO and NHCO 2; R 1 is independently selected from: C 6-10 carbocycle and a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein said carbocycle and heterocycle are substituted with 0-4 R 3 and 0-1 R 4; R 2 independently selected from: OH, CO 2 H, -CONH(C 1-4 alkyl), -CONHOH, -CONHSO 2 R e, and -CONH-(CH 2) 0-3 -(5-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p); R 3, at each occurrence, is independently selected from: halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, C 1-6 haloalkoxy, C 1-4 haloalkylthio, and NO 2; R 4 is independently -L 2 -R 5; L 2 is independently selected from: a bond, O, S, CH 2, C(=O), and -OSO 2; R 5 is independently selected from: C 1-6 alkyl, C 2-6 alkenyl, C 1-6 haloalkyl, -(CH 2) n -C 3-6 carbocycle and a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR b, O, and S p; wherein each ring moiety is substituted with 0-4 R a; R a, at each occurrence, is independently selected from: OH, CN, halogen, C 1-4 alkyl substituted with 0-1 OH, C 1-4 alkoxy, and C 1-4 haloalkyl; R b, at each occurrence, is independently selected from: H, alkyl, and -(CH 2) 0-2 -(phenyl substituted with 0-3 R d); R c, at each occurrence, is independently selected from: halogen, OH, Alkyl, C 1-4 haloalkyl, and C 1-4 alkoxy; R d, at each occurrence, is independently selected from: halogen, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkyl; R e is independently selected from: C 1-4 alkyl and phenyl; p is, independently at each occurrence, selected from 0, 1, and 2; and n is, independently at each occurrence, selected from 0, 1, and 2.