A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: L 1 is -O-; R 1 is H, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocylyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclylalkyl, or substituted heterocycylalkyl; X 1 is alkylene; D 1 is aryl or heteroaryl; D 2 is aryl or heteroaryl; n is 0, 1, or 2; each R 3 and R 4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, haloalkyl, haloalkoxy, heteroalkyl, substituted heteroalkyl, =O, -OR 8, -SR 8, -NR 9 R 10, =NR 8, =NOR 8, =NNR 8 R 9, -CN, -OCN, -SCN, -N=C=O, -NCS, -NO, -NO 2, =N 2, -N 3, -NR 8 C(=O)R 9, -NR 8 C(=O)OR 9, - NR 8 C(=O)NR 9 R 10, -C(=O)NR 9 R 10, -C(=O)OR 8, -OC(=O)NR 9 R 10, -OC(=O)OR 8, -C(=O)R 8, -S(=O) 2 OR 8, -S(=O) 2 R 8, -OS(=O) 2 OR 8, -S(=O) 2 NR 9 R 10, -S(=O)R 8, -NR 8 S(=O) 2 R 9, - NR 8 S(=O) 2 NR 9 R 10, -NR 8 S(=O) 2 OR 9, -OS 2 NR 9 R 10, -OP(=O)(OR 8) 2, -P(=O)(OR 8) 2, -P (OR 8)(R 9), -P R 9 R 10, -OP(=))R 9 R 10, -C(=S)R 8, -C(=S)OR 8, -C(=O)SR 8, -C(=S)SR 8, -C(=S)NR 9 R 10, -C(=NR 8)NR 9 R 10, or -NR 8 C(=NR 8)NR 9 R 10; m is 1 or 2; L 2 is alkylene; X 2 is N or C-R 5; R 5 is H, halogen, alkyl, substituted alkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, cyano, azido, -C H, -C R 8, -S R 8, -S 2 R 8, -S 2 NR 8 R 9, -C OR 8, or -C NR 9 R 10; R 2 is -NR 6 R 7; R 6 and R 7 together with the nitrogen to which they are attached form a substituted or unsubstituted 3 to 8 membered heterocyclyl, which may contain one or more additional heteroatoms selected from N, O, S, or P; and R 8, R 9, and R 10 are each independently H, alkyl, substituted alkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocyclylalkynyl, substituted heterocyclylalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocyclylheteroalkyl, substituted carbocyclylheteroalkyl, heterocyclylheteroalkyl, substituted heterocyclylheteroalkyl, arylheteroalkyl, substituted arylheteroalkyl, heteroarylheteroalkyl, or substituted heteroarylheteroalkyl. L 1 is -O-; R 1 is H, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocylyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclylalkyl, or substituted heterocycylalkyl; X 1 is alkylene; D 1 is aryl or heteroaryl; D 2 is aryl or heteroaryl; n is 0, 1, or 2; each R 3 and R 4 is independently alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, halogen, haloalkyl, haloalkoxy, heteroalkyl, substituted heteroalkyl, =O, -OR 8, -SR 8, -NR 9 R 10, =NR 8, =NOR 8, =NNR 8 R 9, -CN, -OCN, -SCN, -N=C=O, -NCS, -NO, -NO 2, =N 2, -N 3, -NR 8 C(=O)R 9, -NR 8 C(=O)OR 9, - NR 8 C(=O)NR 9 R 10, -C(=O)NR 9 R 10, -C(=O)OR 8, -OC(=O)NR 9 R 10, -OC(=O)OR 8, -C(=O)R 8, -S(=O) 2 OR 8, -S(=O) 2 R 8, -OS(=O) 2 OR 8, -S(=O) 2 NR 9 R 10, -S(=O)R 8, -NR 8 S(=O) 2 R 9, - NR 8 S(=O) 2 NR 9 R 10, -NR 8 S(=O) 2 OR 9, -OS 2 NR 9 R 10, -OP(=O)(OR 8) 2, -P(=O)(OR 8) 2, -P (OR 8)(R 9), -P R 9 R 10, -OP(=))R 9 R 10, -C(=S)R 8, -C(=S)OR 8, -C(=O)SR 8, -C(=S)SR 8, -C(=S)NR 9 R 10, -C(=NR 8)NR 9 R 10, or -NR 8 C(=NR 8)NR 9 R 10; m is 1 or 2; L 2 is alkylene; X 2 is N or C-R 5; R 5 is H, halogen, alkyl, substituted alkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, cyano, azido, -C H, -C R 8, -S R 8, -S 2 R 8, -S 2 NR 8 R 9, -C OR 8, or -C NR 9 R 10; R 2 is -NR 6 R 7; R 6 and R 7 together with the nitrogen to which they are attached form a substituted or unsubstituted 3 to 8 membered heterocyclyl, which may contain one or more additional heteroatoms selected from N, O, S, or P; and R 8, R 9, and R 10 are each independently H, alkyl, substituted alkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylalkenyl, substituted carbocyclylalkenyl, carbocyclylalkynyl, substituted carbocyclylalkynyl, heterocyclylalkenyl, substituted heterocyclylalkenyl, heterocyclylalkynyl, substituted heterocyclylalkynyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroarylalkenyl, substituted heteroarylalkenyl, heteroarylalkynyl, substituted heteroarylalkynyl, carbocyclylheteroalkyl, substituted carbocyclylheteroalkyl, heterocyclylheteroalkyl, substituted heterocyclylheteroalkyl, arylheteroalkyl, substituted arylheteroalkyl, heteroarylheteroalkyl, or substituted heteroarylheteroalkyl.