mhurhangee/ep-ind-claims huggingface dataset:
A recombinant botulinum neurotoxin serotype A comprising at least two domains wherein each domain comprises an amino acid sequence consisting of between 70 and 260 amino acid residues, particularly 100 amino acid residues, 150 amino acid residues, or 200 amino acid residues, wherein said amino acid sequence consists of proline, alanine and serine residues and wherein the neurotoxin further comprises six amino acid modifications at the alpha-exosite of the light chain of the neurotoxin at positions D102, T109, K340, I348, N353, K356, wherein these amino acids are substituted as follows D102F, T109R, K340M, I348L, N353M, K356R and four amino acid modifications at the beta-exosite of the light chain of the neurotoxin at positions G169, T220, P239, S254, wherein these amino acids are substituted as follows G169I, T220R, P239M, S254T, wherein the recombinant botulinum neurotoxin serotype A has a sequence identity of at least about 95% to the corresponding part in the parental botulinum neurotoxin serotype A and wherein the recombinant neurotoxin causes both (i) an increased duration of effect relative to a wildtype botulinum neurotoxin serotype A and (ii) an increased specific biological activity relative to a botulinum neurotoxin serotype A comprising two domains consisting of proline, alanine and serine residues without said modifications in the alpha-exosite and / or at the beta-exosite of the light chain of the neurotoxin.
A composition comprising: - from 5% to 65%, by weight with respect to the total weight of the composition, of calcium silicate crystals; - from 1% to 20%, by weight with respect to the total weight of the composition, of calcium carbonate crystals; - from more than 0% to 50% by weight with respect to the total weight of the composition, of a compound of general formula mCaO.nSiO 2.pH 2 O in which m and n each independently vary from 1 to 3 and p varies from 3 to 6; wherein the d50 granulometry of the calcium silicate crystals ranges from 1 to 5,5 μm; the d50 granulometry of the calcium carbonate crystals ranges from 1 to 5,5 μm; and the ratio between d50 granulometry of the calcium silicate crystals and d50 granulometry of the calcium carbonate crystals is less than 10. - from 5% to 65%, by weight with respect to the total weight of the composition, of calcium silicate crystals; - from 1% to 20%, by weight with respect to the total weight of the composition, of calcium carbonate crystals; - from more than 0% to 50% by weight with respect to the total weight of the composition, of a compound of general formula mCaO.nSiO 2.pH 2 O in which m and n each independently vary from 1 to 3 and p varies from 3 to 6; wherein the d50 granulometry of the calcium silicate crystals ranges from 1 to 5,5 μm; the d50 granulometry of the calcium carbonate crystals ranges from 1 to 5,5 μm; and the ratio between d50 granulometry of the calcium silicate crystals and d50 granulometry of the calcium carbonate crystals is less than 10.
A method for pulse detection of a person by a heart rate monitor including a plurality of multi-axis accelerometers (41R, 41L) adjoined to a platform at different angular orientations, wherein the accelerometers (41R, 41L) are arranged to be mounted, via the platform, on respective body surfaces of the person at the different angular orientations, and wherein the relative angular orientation of the accelerometers (41R, 41L) is rigidly maintained by the body surfaces, the method comprising: each of the accelerometers (41R, 41L) having a vertical axis generating a respective differential mode signal (A ZR, A ZL) indicative of a sensing by the accelerometer of physiological motion normal to a body surface of the person; each of the accelerometers having longitudinal and lateral axes parallel to the body surface for generating common mode signals (A XR, A XL, A YR, A YL) indicative of a sensing by the accelerometers (41R, 41L) of extraneous motion by the person relative to the acceleration sensing axes (42R, 42L); and the heart rate monitor generating a pulse signal as a function of an alignment of the vertical acceleration sensing axes (42R, 42L) combining the differential mode signals (A ZR, A ZL) and cancelling the common mode signals (A XR, A XL, A YR, A YL). each of the accelerometers (41R, 41L) having a vertical axis generating a respective differential mode signal (A ZR, A ZL) indicative of a sensing by the accelerometer of physiological motion normal to a body surface of the person; each of the accelerometers having longitudinal and lateral axes parallel to the body surface for generating common mode signals (A XR, A XL, A YR, A YL) indicative of a sensing by the accelerometers (41R, 41L) of extraneous motion by the person relative to the acceleration sensing axes (42R, 42L); and the heart rate monitor generating a pulse signal as a function of an alignment of the vertical acceleration sensing axes (42R, 42L) combining the differential mode signals (A ZR, A ZL) and cancelling the common mode signals (A XR, A XL, A YR, A YL).
A hair removal device, wherein said device comprises a shell and a hair removal component connected to at least one side of the shell, wherein a hair removal surface is arranged on the side of the hair removal component facing away from the shell, a plurality of pattern groups are arranged on the hair removal surface, the pattern groups comprise at least one main annular convex pattern, and the main annular convex pattern is used to remove hair and dead skin from the surface of skin by rubbing against the skin when the hair removal surface is in contact with the skin, characterised in that: an edge of the end of the main annular convex pattern away from the hair removal surface is provided with a cambered surface structure, and wherein a cross section of the said edge is in arc shape.
A method performed by a terminal in a wireless communication system, the method comprising: identifying whether an active uplink bandwidth part, BWP, is configured with a physical random access channel, PRACH, occasion, upon triggering of a random access procedure on a serving cell; in case that the active uplink BWP is configured with the PRACH occasion: identifying (520, 525) whether a 2-step random access channel, RACH, configuration was received for the active uplink BWP, in case that the terminal supports a 2-step random access procedure; in case that the 2-step RACH configuration was not received for the active uplink BWP, switching the active uplink BWP to an initial uplink BWP and performing the 2-step random access procedure in the initial uplink BWP; and in case that the 2-step RACH configuration was received for the active uplink BWP, performing the 2-step random access procedure in the active uplink BWP without switching the active uplink BWP; and in case that the active uplink BWP is not configured with the PRACH occasion: switching the active uplink BWP to the initial uplink BWP and performing the triggered random access procedure in the initial uplink BWP. identifying whether an active uplink bandwidth part, BWP, is configured with a physical random access channel, PRACH, occasion, upon triggering of a random access procedure on a serving cell; in case that the active uplink BWP is configured with the PRACH occasion: identifying (520, 525) whether a 2-step random access channel, RACH, configuration was received for the active uplink BWP, in case that the terminal supports a 2-step random access procedure; in case that the 2-step RACH configuration was not received for the active uplink BWP, switching the active uplink BWP to an initial uplink BWP and performing the 2-step random access procedure in the initial uplink BWP; and in case that the 2-step RACH configuration was received for the active uplink BWP, performing the 2-step random access procedure in the active uplink BWP without switching the active uplink BWP; and identifying (520, 525) whether a 2-step random access channel, RACH, configuration was received for the active uplink BWP, in case that the terminal supports a 2-step random access procedure; in case that the 2-step RACH configuration was not received for the active uplink BWP, switching the active uplink BWP to an initial uplink BWP and performing the 2-step random access procedure in the initial uplink BWP; and in case that the 2-step RACH configuration was received for the active uplink BWP, performing the 2-step random access procedure in the active uplink BWP without switching the active uplink BWP; and in case that the active uplink BWP is not configured with the PRACH occasion: switching the active uplink BWP to the initial uplink BWP and performing the triggered random access procedure in the initial uplink BWP.
A method for communicating data between a vehicle and a ground system, the method comprising: disposing a pin (210a, 510a) of a connector of a multi-use power interface, which is connected to the ground system, into a socket (320, 520) of a connector (140, 540) of the vehicle such that a lens (350, 550) located on an end of the pin (210a, 510a) mates with an interior surface of a bottom (390, 590) of the socket (320, 520), wherein said lens is concave shaped and the interior surface of the bottom of the socket is convex shaped or said lens is convex shaped and the interior surface of the bottom of the socket is concave shaped, wherein the pin (210a, 510a) and the socket (320, 520) each comprise an optical portion (240a, 540a) and a power portion (280a, 580a); providing, by the ground system, power to an onboard system on the vehicle via the power portions (280a, 580a, 370) of the pin (210a, 510a) and the socket (320, 520); and communicating at least a portion of the data (1110a, 1110b, 1110c) between the onboard system and the ground system via the optical portions (240a, 540a, 380) of the pin (210a, 510a) and the socket (320, 520). disposing a pin (210a, 510a) of a connector of a multi-use power interface, which is connected to the ground system, into a socket (320, 520) of a connector (140, 540) of the vehicle such that a lens (350, 550) located on an end of the pin (210a, 510a) mates with an interior surface of a bottom (390, 590) of the socket (320, 520), wherein said lens is concave shaped and the interior surface of the bottom of the socket is convex shaped or said lens is convex shaped and the interior surface of the bottom of the socket is concave shaped, wherein the pin (210a, 510a) and the socket (320, 520) each comprise an optical portion (240a, 540a) and a power portion (280a, 580a); providing, by the ground system, power to an onboard system on the vehicle via the power portions (280a, 580a, 370) of the pin (210a, 510a) and the socket (320, 520); and communicating at least a portion of the data (1110a, 1110b, 1110c) between the onboard system and the ground system via the optical portions (240a, 540a, 380) of the pin (210a, 510a) and the socket (320, 520).
A magnetoresistance effect element comprising: a first ferromagnetic metal layer; a second ferromagnetic metal layer; and a tunnel barrier layer that is sandwiched between the first and second ferromagnetic metal layers, wherein the tunnel barrier layer has a spinel structure in which cations are arranged in a disordered manner, and the tunnel barrier layer is expressed by a composition formula of (M 1-x Zn x)( 2-y y)O 4, wherein M represents a non-magnetic divalent cation other than Zn, each of T1 and T2 represents a non-magnetic trivalent cation, and x and y represent a composition ratio in a region where composition ratios combined as follows ( to) are vertexes, and the vertexes are connected by straight lines: x=0.2, y=0.1, x=0.8, y=0.1, x=0.8, y=1.7, x=0.6, y=1.7, and x=0.2, y=0.7. a first ferromagnetic metal layer; a second ferromagnetic metal layer; and a tunnel barrier layer that is sandwiched between the first and second ferromagnetic metal layers, wherein the tunnel barrier layer has a spinel structure in which cations are arranged in a disordered manner, and the tunnel barrier layer is expressed by a composition formula of (M 1-x Zn x)( 2-y y)O 4, wherein M represents a non-magnetic divalent cation other than Zn, each of T1 and T2 represents a non-magnetic trivalent cation, and x and y represent a composition ratio in a region where composition ratios combined as follows ( to) are vertexes, and the vertexes are connected by straight lines: x=0.2, y=0.1, x=0.8, y=0.1, x=0.8, y=1.7, x=0.6, y=1.7, and x=0.2, y=0.7. x=0.2, y=0.1, x=0.8, y=0.1, x=0.8, y=1.7, x=0.6, y=1.7, and x=0.2, y=0.7.
An interchangeable barrel system for a pistol comprising: an elongated barrel insert including a rear chamber block defining a chamber configured for holding a cartridge, a front muzzle end, and a forward muzzle portion extending between the muzzle end and the chamber block, the muzzle portion having a bore defining a longitudinal axis and a bullet pathway; an elongated receiver fixedly mounted to a grip frame, the receiver remaining stationary during firing of the pistol, the receiver defining an internal cavity aligned with the longitudinal axis and extending from a rear end to a forward end of the receiver, the muzzle portion of the barrel insert being insertable into and substantially disposed in the cavity; an anti-rotation device configured for preventing rotation of the barrel insert with respect to the receiver; and a locking member threadably engaging the barrel insert and securing the barrel insert in the receiver; the interchangeable barrel system being characterized in that the locking member is a barrel cap that threadably engages the forward muzzle portion of the barrel insert through an open front end of the receiver, and rotating the barrel cap axially draws the barrel insert forward; and rotating the barrel cap tightens the engagement between a forward facing surface of the barrel insert and rear facing surface of the receiver. an elongated barrel insert including a rear chamber block defining a chamber configured for holding a cartridge, a front muzzle end, and a forward muzzle portion extending between the muzzle end and the chamber block, the muzzle portion having a bore defining a longitudinal axis and a bullet pathway; an elongated receiver fixedly mounted to a grip frame, the receiver remaining stationary during firing of the pistol, the receiver defining an internal cavity aligned with the longitudinal axis and extending from a rear end to a forward end of the receiver, the muzzle portion of the barrel insert being insertable into and substantially disposed in the cavity; an anti-rotation device configured for preventing rotation of the barrel insert with respect to the receiver; and a locking member threadably engaging the barrel insert and securing the barrel insert in the receiver;
System for characterising a beam of charged particles, the system comprising a stack, said stack comprising: - an ultra-thin pattern formed from an electrically conductive material; - a thin substrate carrying said pattern; the stack forming an emitting electrode, said emitting electrode being capable of emitting secondary electrons ( e s -) in the proximity of a surface of said pattern when said emitting electrode is passed through by the beam of charged particles. - an ultra-thin pattern formed from an electrically conductive material; - a thin substrate carrying said pattern;
Driver cab of a commercial vehicle with a bodyshell module which has a front wall, two side walls, a rear wall, a driver cab floor and a roof structure which are connected to one another, wherein the roof structure at least partially closes the bodyshell module upwards, wherein the roof structure has a roof frame with two side roof parts in each case at least partially upwardly bounding the side walls, and with a rear roof part which upwardly bounds the rear wall and connects the side roof parts, and wherein a central roof module is provided which is insertable into the roof frame in such a manner that the central roof module in its fitted position adjoins the rear roof part and the side roof parts and extends from the rear roof part into a region above a windscreen of the commercial vehicle, characterized in that the windscreen of the commercial vehicle is at least partially connected directly to the central roof module which is in the fitted position.
An aqueous composition for pretreating a metallic construction material selected from the group consisting of hot-dip-galvanized or rolled steel, electrolytically galvanized steel, steel provided with zinc/aluminum deposition, aluminum/zinc deposition, or zinc/magnesium deposition, aluminum or aluminum alloys, prehardened corrosion-resistant steel, or pure zinc before further coating or for treating said construction material, obtained by adding a) at least sodium, potassium, and/or ammonium water glass, b) at least one silane, and c) at least one organic corrosion inhibitor selected from heterocyclic compounds, carbonamides, and/or acetylacetonates in a quantity of 0.01 to 3% by weight, wherein the quantity ratio of a) to b), in each case including the reaction products arising therefrom, is in the range from 0.1:1 to 2:1 and wherein the concentration in the composition used for the pretreatment corresponds to a) 0.5 to 10% by weight water glass and b) 0.05 to 2% by weight silane. a) at least sodium, potassium, and/or ammonium water glass, b) at least one silane, and c) at least one organic corrosion inhibitor selected from heterocyclic compounds, carbonamides, and/or acetylacetonates in a quantity of 0.01 to 3% by weight, heterocyclic compounds, carbonamides, and/or acetylacetonates a) 0.5 to 10% by weight water glass and b) 0.05 to 2% by weight silane.
A compound of formula, or a pharmaceutically, veterinary or cosmetically acceptable salt thereof, or any stereoisomer or mixtures thereof, either of the compound of formula or of any of its pharmaceutically, veterinary or cosmetically acceptable salts wherein m is an integer selected from 1 to 3; R 1, R 6 and R 6' are independently selected from the group consisting of H, (C 1 -C 8)alkyl, and unsaturated (C 2 -C 8)hydrocarbon; wherein (C 1 -C 8)alkyl, and unsaturated (C 2 -C 8)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6; R 2 is H; R 3 is hydrogen or halogen; R 4 is selected from the group consisting of H, (C 1 -C 8)alkyl and unsaturated (C 2 -C 8)hydrocarbon; wherein (C 1 -C 8)alkyl and unsaturated (C 2 -C 8)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6; R 5 is selected from the group consisting of (C 3 -C 28)alkyl, unsaturated (C 3 -C 28)hydrocarbon, and wherein (C 3 -C 8)alkyl and unsaturated (C 3 -C 28)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6. m is an integer selected from 1 to 3; R 1, R 6 and R 6' are independently selected from the group consisting of H, (C 1 -C 8)alkyl, and unsaturated (C 2 -C 8)hydrocarbon; wherein (C 1 -C 8)alkyl, and unsaturated (C 2 -C 8)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6; R 2 is H; R 3 is hydrogen or halogen; R 4 is selected from the group consisting of H, (C 1 -C 8)alkyl and unsaturated (C 2 -C 8)hydrocarbon; wherein (C 1 -C 8)alkyl and unsaturated (C 2 -C 8)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6; R 5 is selected from the group consisting of (C 3 -C 28)alkyl, unsaturated (C 3 -C 28)hydrocarbon, and wherein (C 3 -C 8)alkyl and unsaturated (C 3 -C 28)hydrocarbon are optionally substituted with one or more substituents selected from the group consisting of halogen, -COOH, -OH, -NH 2, -COOR 6, -NO 2, -CF 3, -OCF 3, -CN, -OR 6, -CONH 2, -CONHR 6, -NHR 6, -NHCOR 6, -NHSO 2 R 6, and -SO 2 NHR 6.
A method, performed in a User Equipment, UE, associated with a Radio Access Network, RAN, using Internet transport, of mitigating the impact on a RAN service level due to Internet attacks, the method comprising: - receiving from at least a network node (11, 12, 21, 22, 23) in the RAN, information associated with an Internet attack, - obtaining, based on the information, a mitigation action, the mitigation action mitigating the impact, of the Internet attack, on the RAN service level; and - performing the obtained mitigation action to mitigate the impact on the RAN service level, wherein the mitigation action comprises moving the UE to another network node (11, 12, 21, 22, 23). - receiving from at least a network node (11, 12, 21, 22, 23) in the RAN, information associated with an Internet attack, - obtaining, based on the information, a mitigation action, the mitigation action mitigating the impact, of the Internet attack, on the RAN service level; and - performing the obtained mitigation action to mitigate the impact on the RAN service level, wherein the mitigation action comprises moving the UE to another network node (11, 12, 21, 22, 23).
A multivalent antigenic composition for use in the prevention or treatment of breast cancer in a patient, wherein the composition is for administration to the patient in an effective amount, and wherein the composition comprises an adjuvant and two or more polypeptides, wherein the two or more polypeptides comprise: I. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising an αS1 casein sequence of SEQ ID NO: 2; II. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising a β-casein sequence of SEQ ID NO: 3; or III. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising a κ-casein sequence of SEQ ID NO: 4. I. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising an αS1 casein sequence of SEQ ID NO: 2; II. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising a β-casein sequence of SEQ ID NO: 3; or III. a polypeptide comprising an α-lactalbumin sequence of SEQ ID NO: 1, and a polypeptide comprising a κ-casein sequence of SEQ ID NO: 4.