mhurhangee/ep-ind-claims huggingface dataset:
A polynucleotide encoding a polyepitope and comprising at least two consecutive polynucleotidic units encoding a HLA-B7-restricted hTERT epitope chosen from the group consisting of: a. MPRAPRCRA, b. APRCRAVRSL, c. APSFRQVSCL, d. RPAEEATSL, e. RPSFLLSSL, f. RPSLTGARRL, g. DPRRLVQLL, h. FVRACLRRL, i. AGRNMRRKL, j. LPGTTLTAL, and k. LPSPKFTIL, wherein said polynucleotide is not the coding sequence of the full length hTERT, for use in the prevention and/or treatment of cancer, by induction of a HLA-B7-restricted immune response. a. MPRAPRCRA, b. APRCRAVRSL, c. APSFRQVSCL, d. RPAEEATSL, e. RPSFLLSSL, f. RPSLTGARRL, g. DPRRLVQLL, h. FVRACLRRL, i. AGRNMRRKL, j. LPGTTLTAL, and k. LPSPKFTIL,
A compound for use in a method of inhibiting a coronavirus infection in an individual in need thereof, wherein the compound is a nAChR agonist, or a pharmaceutically acceptable salt thereof, wherein the nAChR agonist is varenicline, wherein the method comprises locally administering the nAChR agonist, or a pharmaceutically acceptable salt thereof, into the respiratory tract of the individual in need thereof, and wherein the method further comprises locally administering a pharmaceutically acceptable salt of copper into the respiratory tract of the individual in need thereof.
An antibody or a functional fragment thereof binding to 3'-sialyl lactose and comprising: (i) a heavy chain variable region which comprises a CDR1 sequence consisting of an amino acid sequence GIDFSIYW (SEQ ID NO: 1), a CDR2 sequence consisting of an amino acid sequence INSDSSTI (SEQ ID NO: 2), and a CDR3 sequence consisting of an amino acid sequence ARKNGGLDYAMDY (SEQ ID NO: 3), and (ii) a light chain variable region which comprises a CDR1 sequence consisting of an amino acid sequence KSISKY (SEQ ID NO: 4), a CDR2 sequence consisting of an amino acid sequence SGS, and a CDR3 sequence consisting of an amino acid sequence QQHNEYPWT (SEQ ID NO: 5). (i) a heavy chain variable region which comprises a CDR1 sequence consisting of an amino acid sequence GIDFSIYW (SEQ ID NO: 1), a CDR2 sequence consisting of an amino acid sequence INSDSSTI (SEQ ID NO: 2), and a CDR3 sequence consisting of an amino acid sequence ARKNGGLDYAMDY (SEQ ID NO: 3), and (ii) a light chain variable region which comprises a CDR1 sequence consisting of an amino acid sequence KSISKY (SEQ ID NO: 4), a CDR2 sequence consisting of an amino acid sequence SGS, and a CDR3 sequence consisting of an amino acid sequence QQHNEYPWT (SEQ ID NO: 5).
A turbofan gas turbine engine system comprising: a variable pitch fan assembly coupled to a first rotatable shaft; a low pressure compressor LPC coupled to a second rotatable shaft, said LPC including a plurality of variable pitch stator vanes interdigitated with rows of blades of a rotor of the LPC; a core engine configured in series flow arrangement with said VPF and said LPC; a speed reduction device coupled to said first rotatable shaft and said second rotatable shaft, said speed reduction device configured to drive said first rotatable shaft at a rotational speed that is lower than the rotational speed of the second rotatable shaft; a modulating pressure relief valve positioned between an outlet of said LPC and a bypass duct; and a controller configured to schedule a position of said plurality of variable pitch stator vanes and said modulating pressure relief valve in response to an operational state of said turbofan gas turbine engine system and a temperature associated with said LPC. a variable pitch fan assembly coupled to a first rotatable shaft; a low pressure compressor LPC coupled to a second rotatable shaft, said LPC including a plurality of variable pitch stator vanes interdigitated with rows of blades of a rotor of the LPC; a core engine configured in series flow arrangement with said VPF and said LPC; a speed reduction device coupled to said first rotatable shaft and said second rotatable shaft, said speed reduction device configured to drive said first rotatable shaft at a rotational speed that is lower than the rotational speed of the second rotatable shaft; a modulating pressure relief valve positioned between an outlet of said LPC and a bypass duct; and a controller configured to schedule a position of said plurality of variable pitch stator vanes and said modulating pressure relief valve in response to an operational state of said turbofan gas turbine engine system and a temperature associated with said LPC.
Earphones for connection to a multimedia device that is suitable for telephone operation and audio recording/playback operation, wherein the earphones comprise: - two ear units (271,272), wherein each ear unit comprises at least a sound generator (271S,272S) and a microphone (271M,272M) for recording ambient sound at an ear of a user; - at least one further microphone for acquiring speech of the user; - a connection unit (75, 22, 225, 225') that is suitable for connecting the earphones with the multimedia device; wherein the connection unit may output to the multimedia device, in a selectable and user adjustable manner, either audio signals from the two microphones (271M,272M) for binaurally recording ambient sound or audio signals of the further microphone for acquiring speech, and wherein when the multimedia device switches to the telephone mode, the earphones switch automatically to a mode in which the connection unit outputs audio signals of only the further microphone. - two ear units (271,272), wherein each ear unit comprises at least a sound generator (271S,272S) and a microphone (271M,272M) for recording ambient sound at an ear of a user; - at least one further microphone for acquiring speech of the user; - a connection unit (75, 22, 225, 225') that is suitable for connecting the earphones with the multimedia device;
A device comprising: circuitry configured to determine, based on an input from one or more motion sensors, a tilt angle of the device; select, based on the tilt angle, an application interface, of one or more application interfaces; and control a display panel to display the selected application interface, wherein the circuitry is configured to determine, based on the input from one or more motion sensors, the orientation of the device, and the circuitry is configured to select the layout of icons of the selected application interface based on the tilt angle and the display orientation as a prediction of an intended operation of the device based on a manner in which the device is typically operated by a user. circuitry configured to determine, based on an input from one or more motion sensors, a tilt angle of the device; select, based on the tilt angle, an application interface, of one or more application interfaces; and control a display panel to display the selected application interface, wherein the circuitry is configured to determine, based on the input from one or more motion sensors, the orientation of the device, and determine, based on an input from one or more motion sensors, a tilt angle of the device; select, based on the tilt angle, an application interface, of one or more application interfaces; and control a display panel to display the selected application interface, wherein the circuitry is configured to determine, based on the input from one or more motion sensors, the orientation of the device, and the circuitry is configured to select the layout of icons of the selected application interface based on the tilt angle and the display orientation as a prediction of an intended operation of the device based on a manner in which the device is typically operated by a user.
Three-dimensionally shaped vehicle armouring component, comprising a steel sheet made of armoured steel which is at least partially hot formed and press hardened, characterised in that the steel sheet has, at least on one side, a coating connected to the steel sheet, wherein the coating consists of a metal material that is softer than the armoured steel and the coating is a thermally sprayed-on layer, wherein the coating has a thickness of 0.05 mm to 0.2 mm and the steel sheet has a hardness of 520 to 620 Vickers and the coating has a hardness of 20 to 100 Vickers.
Electrical circuit for testing primary internal signals of an ASIC, wherein only one test pin (TEST) is provided, via which it is possible to select digital signals (D 1, D 2,..., D n) to be observed or an analogue signal (A 1, A 2,..., A m), characterized in that - a Schmitt trigger (SMT 1) is arranged between the test pin (TEST) and an output connection of the electrical circuit, wherein provision is made to activate a test mode if a switching threshold of the Schmitt trigger (SMT 1) is exceeded, and - at least one sub-circuit with a resistor (R 1, R 2,..., R n), an NMOS transistor (M 1, M 2,..., M n) and an AND gate (X 1, X 2,..., X n), the first input of which has the digital signal (D 1, D 2,..., D n) applied to it, is provided for observing a digital signal (D 1, D 2,..., D n), wherein the resistor (R 1, R 2,..., R n) is arranged between the test pin (TEST) and the drain connection of the NMOS transistor (M 1, M 2,..., M n), the source connection of the NMOS transistor (M 1, M 2,..., M n) is connected to earth, the gate connection of the NMOS transistor (M 1, M 2,..., M n) is connected to the output of the AND gate (X 1, X 2,..., X n) and the second input of the AND gate (X 1, X 2,..., X n) is connected to the output connection of the electrical circuit. - a Schmitt trigger (SMT 1) is arranged between the test pin (TEST) and an output connection of the electrical circuit, wherein provision is made to activate a test mode if a switching threshold of the Schmitt trigger (SMT 1) is exceeded, and - at least one sub-circuit with a resistor (R 1, R 2,..., R n), an NMOS transistor (M 1, M 2,..., M n) and an AND gate (X 1, X 2,..., X n), the first input of which has the digital signal (D 1, D 2,..., D n) applied to it, is provided for observing a digital signal (D 1, D 2,..., D n), wherein the resistor (R 1, R 2,..., R n) is arranged between the test pin (TEST) and the drain connection of the NMOS transistor (M 1, M 2,..., M n), the source connection of the NMOS transistor (M 1, M 2,..., M n) is connected to earth, the gate connection of the NMOS transistor (M 1, M 2,..., M n) is connected to the output of the AND gate (X 1, X 2,..., X n) and the second input of the AND gate (X 1, X 2,..., X n) is connected to the output connection of the electrical circuit.
A method of monitoring enzymatic activity in a live animal to which a composition has been administered, the composition comprising a chemiluminescent probe and a near-infrared nanoparticle, wherein: (i) the chemiluminescent probe consists of a chemiluminescent probe that detects the presence of a product of endogenous enzyme activity in a live animal by emitting chemiluminescence; (ii) the NIR nanoparticle emits light upon exposure to the chemiluminescence emitted from the chemiluminescent probe; and (iii) the composition does not include an exogenous enzyme; the method comprising: detecting the light emitted from the NIR nanoparticle, thereby monitoring enzymatic activity in the live animal, wherein the NIR nanoparticle emits light upon exposure to the chemiluminescence emitted from the chemiluminescent probe. (i) the chemiluminescent probe consists of a chemiluminescent probe that detects the presence of a product of endogenous enzyme activity in a live animal by emitting chemiluminescence; (ii) the NIR nanoparticle emits light upon exposure to the chemiluminescence emitted from the chemiluminescent probe; and (iii) the composition does not include an exogenous enzyme;
A method of analyzing an electrical current over a target surface (18, 24), comprising: providing a plurality of magnetic field sensors at known locations in an array, wherein the array is sufficiently larger than the target surface that when the array is positioned proximate the target surface, a subset of said plurality of magnetic field sensors is positioned beyond the outer edges of the target surface, each sensor being operatively connected to an integrator; positioning the plurality of magnetic field sensors proximate the target surface; applying an electrical current to the target surface; sensing a change in magnetic field strength at one or more sensor locations; integrating the changes in magnetic field strength to derive a magnetic field strength value at each of the one or more sensor locations; inferring a current density over the target surface from the plurality of magnetic field strength values and corresponding sensor locations; interpolating magnetic field strength values between sensor locations; calculating virtual sensor locations corresponding to the interpolated magnetic field strength values; inferring a local virtual current value from each interpolated magnetic field strength value; and mapping the local virtual current values to the target surface using the corresponding virtual sensor locations. providing a plurality of magnetic field sensors at known locations in an array, wherein the array is sufficiently larger than the target surface that when the array is positioned proximate the target surface, a subset of said plurality of magnetic field sensors is positioned beyond the outer edges of the target surface, each sensor being operatively connected to an integrator; positioning the plurality of magnetic field sensors proximate the target surface; applying an electrical current to the target surface; sensing a change in magnetic field strength at one or more sensor locations; integrating the changes in magnetic field strength to derive a magnetic field strength value at each of the one or more sensor locations; inferring a current density over the target surface from the plurality of magnetic field strength values and corresponding sensor locations; interpolating magnetic field strength values between sensor locations; calculating virtual sensor locations corresponding to the interpolated magnetic field strength values; inferring a local virtual current value from each interpolated magnetic field strength value; and mapping the local virtual current values to the target surface using the corresponding virtual sensor locations.
A sports shoe, in particular a soccer shoe, comprising: a. a shoe upper with a closure region and a sole region; and b. at least one reinforcing element attached to the inside of the shoe upper and arranged in a midfoot part and comprising a plurality of flexible bands extending between the closure region and the sole region, wherein the plurality of bands comprises bands at the medial inside and at the lateral inside of the shoe upper, and characterised in that the bands at the medial inside of the shoe upper are formed more elastic than the bands at the lateral inside of the shoe upper. a. a shoe upper with a closure region and a sole region; and b. at least one reinforcing element attached to the inside of the shoe upper and arranged in a midfoot part and comprising a plurality of flexible bands extending between the closure region and the sole region, wherein the plurality of bands comprises bands at the medial inside and at the lateral inside of the shoe upper, and characterised in that the bands at the medial inside of the shoe upper are formed more elastic than the bands at the lateral inside of the shoe upper.
A cooling arrangement for cooling an electronic device, the electronic device including a heat-generating component, the cooling arrangement comprising: an immersion casing that contains a dielectric cooling liquid, the electronic device being, at least in part, adapted to be immersed in the dielectric cooling liquid such that the dielectric cooling liquid is adapted to collect, in use, at least a first portion of a thermal energy generated by the heat-generating component; and characterized by a photovoltaic device proximate to the immersion casing and configured to convert at least in part a second portion of the thermal energy generated by the heat-generating component into electric energy, the second portion having radiated from the dielectric cooling liquid and through the immersion casing. an immersion casing that contains a dielectric cooling liquid, the electronic device being, at least in part, adapted to be immersed in the dielectric cooling liquid such that the dielectric cooling liquid is adapted to collect, in use, at least a first portion of a thermal energy generated by the heat-generating component; and characterized by a photovoltaic device proximate to the immersion casing and configured to convert at least in part a second portion of the thermal energy generated by the heat-generating component into electric energy, the second portion having radiated from the dielectric cooling liquid and through the immersion casing.
An operation input device comprising: an operation unit including an operation plate for receiving an operation of an operator and a support unit for supporting the operation plate in such a way as to allow the operation plate to be tilted; a detection unit for detecting an operation of tilting the operation plate; an identification unit for identifying a tilt position of the operation plate for which tilting operation has been detected; and a setting unit for setting an orientation of an operation target included in a target apparatus to an orientation corresponding to the tilt position of the operation plate identified by the identification unit, whereby when the operation plate is tilted at a tilted position selected by the operator from among a plurality of tilted positions, the identification unit identifies the tilted position selected by the operator, characterized in that the operation unit holds the operation plate in the tilted position selected by the operator. an operation unit including an operation plate for receiving an operation of an operator and a support unit for supporting the operation plate in such a way as to allow the operation plate to be tilted; a detection unit for detecting an operation of tilting the operation plate; an identification unit for identifying a tilt position of the operation plate for which tilting operation has been detected; and a setting unit for setting an orientation of an operation target included in a target apparatus to an orientation corresponding to the tilt position of the operation plate identified by the identification unit, whereby when the operation plate is tilted at a tilted position selected by the operator from among a plurality of tilted positions, the identification unit identifies the tilted position selected by the operator, characterized in that the operation unit holds the operation plate in the tilted position selected by the operator.
A method, comprising: repeatedly updating a discrete time model of a process to be controlled using a continuous time model of the process, wherein the discrete time model is updated at multiple sampling times, and wherein different sampling times are associated with different types of events; predicting measurements or states to be used by a controller to control the process, the predicted measurements or states generated using the repeatedly updated discrete time model of the process; providing the predicted measurements or states to the controller such that the controller uses the predicted measurements or states at a sampling rate of the controller; and updating at least some of the predicted measurements or states using measurements associated with a characteristic of an item from a sensor. repeatedly updating a discrete time model of a process to be controlled using a continuous time model of the process, wherein the discrete time model is updated at multiple sampling times, and wherein different sampling times are associated with different types of events; predicting measurements or states to be used by a controller to control the process, the predicted measurements or states generated using the repeatedly updated discrete time model of the process; providing the predicted measurements or states to the controller such that the controller uses the predicted measurements or states at a sampling rate of the controller; and updating at least some of the predicted measurements or states using measurements associated with a characteristic of an item from a sensor.
A marine pipeline installation vessel for laying a pipeline on the seabed, said vessel at least being adapted to carry out the reel lay method, wherein the vessel comprises: • at least a first and a second storage reel (SR1 SR2) for storage of the pipeline to be laid, which storage reels are positioned in or onto the vessel; • a pipeline launch tower mounted to the vessel, which pipeline launch tower is adapted to launch the pipeline in a firing line along said tower; • a pipeline guide which is mounted at an elevated position to the pipeline launch tower, which pipeline guide has a pipeline guide surface member (PGSM) providing an essentially circular or semi-circular pipeline guide surface, which pipeline guide is adapted to - in a primary pipelaying position thereof relative to the tower - guide a pipeline from a first storage reel over the pipeline guide into the firing line, wherein said pipeline contacts the pipeline guide surface at a first contact point fore of the firing line and departs said surface at a first departure point into the firing line, characterized in that a pipeline guide displacement drive is provided which is adapted to displace the pipeline guide with respect to the tower between the primary pipelaying position and a secondary pipelaying position thereof, which pipeline guide is adapted to - in the secondary pipelaying position - guide a pipeline from a second storage reel over the pipeline guide into the firing line, wherein said pipeline contacts the pipeline guide surface at a second contact point aft of the firing line and departs said surface at a second departure point into the firing line, wherein the first and second departure points are both in the firing line, and wherein the first and second contact points are positioned fore and aft of the firing line, respectively. • at least a first and a second storage reel (SR1 SR2) for storage of the pipeline to be laid, which storage reels are positioned in or onto the vessel; • a pipeline launch tower mounted to the vessel, which pipeline launch tower is adapted to launch the pipeline in a firing line along said tower; • a pipeline guide which is mounted at an elevated position to the pipeline launch tower, which pipeline guide has a pipeline guide surface member (PGSM) providing an essentially circular or semi-circular pipeline guide surface, which pipeline guide is adapted to - in a primary pipelaying position thereof relative to the tower - guide a pipeline from a first storage reel over the pipeline guide into the firing line, wherein said pipeline contacts the pipeline guide surface at a first contact point fore of the firing line and departs said surface at a first departure point into the firing line,