mhurhangee/ep-ind-claims huggingface dataset:
A modified immune cell engineered to express: (a) a fusion protein comprising an extracellular domain, a transmembrane domain, and an intracellular domain, wherein the extracellular domain is at least a portion of the extracellular domain of an inhibitory polypeptide that is associated with a negative signal that prevents activation of an immune response and/or induces apoptosis in an immune cell that expresses the inhibitory polypeptide, and wherein the intracellular domain is at least a portion of the intracellular domain of a stimulatory polypeptide that is associated with a positive signal that activates an immune cell that expresses the inhibitory polypeptide; and (b) a chimeric antigen receptor comprising: an antigen recognition domain of a specific antibody that binds a tumor antigen and an intracellular domain of the CD3-zeta chain, wherein the fusion protein when displayed on the modified immune cell is able to switch the negative signal to the positive signal in the modified immune cell for enhancement of an immune response. (a) a fusion protein comprising an extracellular domain, a transmembrane domain, and an intracellular domain, wherein the extracellular domain is at least a portion of the extracellular domain of an inhibitory polypeptide that is associated with a negative signal that prevents activation of an immune response and/or induces apoptosis in an immune cell that expresses the inhibitory polypeptide, and wherein the intracellular domain is at least a portion of the intracellular domain of a stimulatory polypeptide that is associated with a positive signal that activates an immune cell that expresses the inhibitory polypeptide; and (b) a chimeric antigen receptor comprising: an antigen recognition domain of a specific antibody that binds a tumor antigen and an intracellular domain of the CD3-zeta chain, wherein the fusion protein when displayed on the modified immune cell is able to switch the negative signal to the positive signal in the modified immune cell for enhancement of an immune response. an antigen recognition domain of a specific antibody that binds a tumor antigen and an intracellular domain of the CD3-zeta chain,
Constant velocity joint, consisting of an input shaft, an output shaft and a stabilising mechanism, which is inserted into the space between the input shaft and the output shaft, where the input shaft is provided with several rotation hubs (1.1 to 1.n), the output shaft is provided with several rotation hubs (2.1 to 2.n), the stabilization mechanism consisting of identical or similar stabilising segments (3.1 to 3.n), bound together into a single unit with a possibility of mutual rotation of stabilising segments (3.1 to 3.n) around the axis of the stabilising mechanism, while in the space between the input and the output shaft pairs of spherical arms are placed in a way that each spherical arm is rotationally fixed by one its end to one of rotation hubs (1.1 to 1.n) of the input shaft and its other end is rotationally attached to one of stabilising segment (3.1 to 3.n) of the stabilising mechanism, each spherical arm is rotationally fixed by one its end to one of rotation hubs (2.1 to 2.n) of the output shaft and its other end is rotationally attached to one of stabilising segments (3.1 to 3.n) of the stabilising mechanism, each stabilising segment (3.1 to 3.n) bears two separate rotational axes, the axes of rotation hubs (a3.1, a3.2), which are carried by each of stabilising segments (3.1 to 3.n) and around which the spherical arms (4L, 4R) rotate, intersect each other on the axis of the stabilising mechanism or intersect each other above the axis of the stabilising mechanism or intersect under the axis of the stabilising mechanism, and the number of pairs of spherical arms equals to the number two characterized by the fact that the spherical arm and the spherical arm in each of both pairs of spherical arms are connected by a mechanical bond, in a way that both arms are mutually bounded and may perform a motion, which is mirror-like toward a homokinetic plane.
A method of setting at least one microwave source of a cooking device, in the cooking chamber of which at least microwaves can be applied to a cooking product as a function of output data from at least one temperature probe which can be inserted at least partially into the cooking product, by means of which temperature probe at least one temperature within a barrier layer of the cooking product can be detected, wherein the method comprises at least two phases, wherein the barrier layer of the cooking product is heated up at least by microwave application at most to a specified first temperature threshold value in the first phase, and the microwave application is changed in the second phase in comparison to the first phase by reducing the microwave power emitted by the at least one microwave source at least once, wherein a check is carried out as to whether the event occurs that i) at least one barrier layer temperature is increased to the temperature threshold value, characterized in that a simultaneous check is carried out as to whether the event occurs that ii) after a particular period of time has elapsed since the start of the first phase at least one barrier layer temperature has still not increased to the first temperature threshold value and does not fall when the microwave power of the at least one microwave source is reduced, in particular by switching off the at least one microwave source, wherein a change is made from the first phase to the second phase as soon as one of the events occurs and the phase change is triggered by the event which occurs first in terms of timing. i) at least one barrier layer temperature is increased to the temperature threshold value, characterized in that a simultaneous check is carried out as to whether the event occurs that ii) after a particular period of time has elapsed since the start of the first phase at least one barrier layer temperature has still not increased to the first temperature threshold value and does not fall when the microwave power of the at least one microwave source is reduced, in particular by switching off the at least one microwave source, wherein
A variable density lattice metal having vibration damping characteristics, characterized in that each of the cells of the lattice metal has a tetradecahedron structure, a combination structure of a dodecahedron and a tetradecahedron, or a truncated octahedron structure, and the cells are expanded to form the lattice metal; wherein the lattice metal is based on a modal strain energy method to drive the design of pore strut diameters, and the overall structural density shows a non-homogeneous continuous gradient change, wherein the modal strain energy method is used to calculate a modal shape of the structure through a finite element software, a modal strain is extracted and a modal strain energy point cloud diagram is constructed, a continuous gradient change of the pore strut diameters of the lattice metal is driven through a strain energy field function, and the value of the pore strut diameters of the lattice metal in an area with large modal strain energy is larger than in an area of small strain energy, wherein the gradient change of the pore strut diameters of the variable-density lattice metal is not in a single direction; wherein the variable density lattice metal is prepared by a selective laser melting additive manufacturing process; wherein the porosity of the lattice metal is 40% to 90%, the pore strut diameters change continuously in the range of 0.5mm to 5mm, the step size of the continuous gradient change of the pore strut diameters of the lattice metal is 0.08-0.2 mm, and the cell size of the lattice metal is 5 to 10mm. wherein the lattice metal is based on a modal strain energy method to drive the design of pore strut diameters, and the overall structural density shows a non-homogeneous continuous gradient change, wherein the modal strain energy method is used to calculate a modal shape of the structure through a finite element software, a modal strain is extracted and a modal strain energy point cloud diagram is constructed, a continuous gradient change of the pore strut diameters of the lattice metal is driven through a strain energy field function, and the value of the pore strut diameters of the lattice metal in an area with large modal strain energy is larger than in an area of small strain energy, wherein the gradient change of the pore strut diameters of the variable-density lattice metal is not in a single direction; wherein the variable density lattice metal is prepared by a selective laser melting additive manufacturing process; wherein the porosity of the lattice metal is 40% to 90%, the pore strut diameters change continuously in the range of 0.5mm to 5mm, the step size of the continuous gradient change of the pore strut diameters of the lattice metal is 0.08-0.2 mm, and the cell size of the lattice metal is 5 to 10mm.
A treatment composition comprising: (a) microcapsules, the microcapsules comprising a microcapsule core and a microcapsule wall which encapsulates the microcapsule core, wherein (i) the microcapsule wall is formed by cross-linking formaldehyde with at least one other monomer; and (ii) the microcapsule core comprises a perfume, the perfume comprising a perfume raw material selected from the group consisting of aldehydes, ketones, and mixtures thereof; (b) a primary or secondary amine; and (c) a formaldehyde scavenger wherein the formaldehyde scavenger is urea. (a) microcapsules, the microcapsules comprising a microcapsule core and a microcapsule wall which encapsulates the microcapsule core, wherein (i) the microcapsule wall is formed by cross-linking formaldehyde with at least one other monomer; and (ii) the microcapsule core comprises a perfume, the perfume comprising a perfume raw material selected from the group consisting of aldehydes, ketones, and mixtures thereof; (i) the microcapsule wall is formed by cross-linking formaldehyde with at least one other monomer; and (ii) the microcapsule core comprises a perfume, the perfume comprising a perfume raw material selected from the group consisting of aldehydes, ketones, and mixtures thereof; (b) a primary or secondary amine; and (c) a formaldehyde scavenger wherein the formaldehyde scavenger is urea.
An auxiliary lock for a lock, wherein the auxiliary lock comprises: - at least one latching element (22, 22') which is adjustable between a latched position and an unlatched position, with the latching element (22, 22') located in the unlatched position being automatically adjustable into the latched position; and - at least one latch bolt (20, 20') which is displaceably supported between an extended position and a retracted position, wherein a respective frame-side recess, into which the latching element (22, 22') located in the latched position and the latch bolt (20, 20') located in the extended position engage in the closed position of the lock, is associated with the latch bolt (20, 20') and with the latching element (22, 22'); wherein the latch bolt (20, 20') of the auxiliary lock and the latching element (22, 22') of the auxiliary lock are mutually arranged such that the latch bolt (20, 20') which has at least partly moved into the recess of the frame associated with the latch bolt (20, 20') holds the lock in a position in which the latching element (22, 22') of the auxiliary lock can be moved into the recess of the frame associated with the latching element (22, 22') in a substantially friction-free manner, in particular with clearance; wherein the latching element (22, 22') is coupled to a transmission element of the auxiliary lock via a coupling element which is in particular pin-shaped, with the coupling element being respectively displaceably supported at the latching element (22, 22'), at the transmission element and at a part of the auxiliary lock fixed to the housing; and wherein the part fixed to the housing forms an abutment for the coupling element in the latched position of the latching element (22, 22'), said abutment blocking a pushing back of the latching element (22, 22') in the direction of the unlatched position. - at least one latching element (22, 22') which is adjustable between a latched position and an unlatched position, with the latching element (22, 22') located in the unlatched position being automatically adjustable into the latched position; and - at least one latch bolt (20, 20') which is displaceably supported between an extended position and a retracted position,
An isolated phycobilin for use in a method for prophylaxis or treatment of glomerulosclerosis associated with or linked to an NADPH oxidase activity, the method comprising the step of administering the isolated phycobilin to a subject in a prophylactically or therapeutically effective amount for prophylaxis or treatment of the glomerulosclerosis associated with or linked to an NADPH oxidase activity.
The use of a polymer dispersion for producing sound deadener compositions, the polymer dispersion comprising at least one polymer obtainable by emulsion polymerization of radically polymerizable monomers, and the polymer having alkyleneimine side chains, the alkyleneimine side chains having one or more alkyleneimine units.
A body motion detection device (100A, 100B) comprising: a count unit adapted to count a number of steps in a walking mode by detecting a body motion; a calculation unit adapted to calculate an amount of exercise based on said counted number of steps; said walking mode including a first walking mode and a second walking mode, wherein said first walking mode corresponds to a normal walking mode and said second walking mode corresponds to a walking mode in Nordic walking, a receiving unit adapted to receive from an information transmission device attached to a Nordic walking pole a signal indicating start or end of said walking mode in Nordic walking, said signal containing information identifying said information transmission device, and a setting unit adapted to set, as a parameter used in said calculation unit, a parameter for said first walking mode or a parameter for said second walking mode based on said signal, wherein said setting unit is adapted, when the parameter for the first walking mode is set, to set a parameter corresponding to said information transmission device, identified based on said signal, as the parameter for said second walking mode based on said information contained in said signal. a count unit adapted to count a number of steps in a walking mode by detecting a body motion; a calculation unit adapted to calculate an amount of exercise based on said counted number of steps; said walking mode including a first walking mode and a second walking mode,
Pressure pulsation damper for a fuel injection system, in particular a common-rail injection system, comprising a tubular line section in which there is formed a fuel channel which is connected to a pressure damping chamber, the pressure damping chamber being annular and arranged around the tubular line section, characterized in that multiple shell-side openings connect the fuel channel formed in the interior of the tubular line section to the annular pressure damping chamber, wherein multiple spherical gas-filled elements are accommodated in an annular arrangement in the pressure damping chamber.
Method for improving the quality of MR images, comprising: - capturing k-space measurement data of a plurality of k-space portions comprising an examination object by means of a magnetic resonance system, - distributing the k-space measurement data into at least two k-space bins (42, 43), each comprising at least one k-space portion, - reconstructing a bin MR image (44, 45) from each of the k-space bins (42, 43) in each case, - determining at least one motion correction parameter using the reconstructed bin MR images (44, 45), - carrying out a correction of at least one k-space bin (42, 43) by means of the at least one motion correction parameter, characterised in that the method comprises the following steps: - reconstructing a corrected bin MR image (51, 52) from each of the corrected k-space bins (46, 47) in each case, - generating an MR image by means of the at least one motion correction parameter, wherein the MR image is generated from the corrected bin MR images (51, 52) and the remaining bin MR images. - capturing k-space measurement data of a plurality of k-space portions comprising an examination object by means of a magnetic resonance system, - distributing the k-space measurement data into at least two k-space bins (42, 43), each comprising at least one k-space portion, - reconstructing a bin MR image (44, 45) from each of the k-space bins (42, 43) in each case, - determining at least one motion correction parameter using the reconstructed bin MR images (44, 45), - carrying out a correction of at least one k-space bin (42, 43) by means of the at least one motion correction parameter, characterised in that the method comprises the following steps: - reconstructing a corrected bin MR image (51, 52) from each of the corrected k-space bins (46, 47) in each case, - generating an MR image by means of the at least one motion correction parameter, wherein the MR image is generated from the corrected bin MR images (51, 52) and the remaining bin MR images. - reconstructing a corrected bin MR image (51, 52) from each of the corrected k-space bins (46, 47) in each case, - generating an MR image by means of the at least one motion correction parameter, wherein the MR image is generated from the corrected bin MR images (51, 52) and the remaining bin MR images.
A cryoprotection medium for the cryopreservation of adipose tissue, characterized therein that said cryoprotection medium is a solution of physiological water comprising glycerol present in an amount from 1.6 M to 2.7 M and sucrose present in an amount from 0.1 M to 0.3 M.
Geared positive-displacement machine, comprising: - a housing provided with a suction port and with a discharge port, - a pair of gearwheels (14, 15) which are housed and supported by respective shafts (16, 18) for the rotation in a space inside said housing and in fluid communication with said suction port and said discharge port, wherein said gearwheels (14, 15) mesh with each other and are provided with parallel axes and a first wheel thereof is driving and a second wheel is driven, and - a pair of containment bodies (19, 20) for axially containing said wheels (14, 15), said containment bodies (19, 20) being associated with said housing and each comprising a first face (19a, 20a) which faces said pair of gearwheels (14, 15) and a second face (19b, 20b) which is axially opposite said first face (19a, 20a), - for each of said wheels (14, 15), a plurality of rolling bodies which form a crown and which are freely housed in an annular seat that is coaxial to the respective shaft (16, 18) and that is defined at the interface between said first face (19a, 20a) of at least one of said containment bodies (19, 20) and the surface (14a, 15a; 14b, 15b) of said wheels (14, 15) facing it, respectively in said first face (19a, 20a) of at least one of said containment bodies or in said surface (14a, 15a; 14b, 15b) of said gearwheels facing said first face (19a, 20a) characterized in that said rolling bodies rest on rolling tracks (23, 24) respectively integral with said wheels (14, 15) and with said at least one containment body (19, 20), when between said first face (19a, 20a) of said at least one containment body (19, 20) and the surface (14a, 15a; 14b, 15b) of said wheels (14, 15) facing said first face a distance greater than zero exists. - a housing provided with a suction port and with a discharge port, - a pair of gearwheels (14, 15) which are housed and supported by respective shafts (16, 18) for the rotation in a space inside said housing and in fluid communication with said suction port and said discharge port, wherein said gearwheels (14, 15) mesh with each other and are provided with parallel axes and a first wheel thereof is driving and a second wheel is driven, and - a pair of containment bodies (19, 20) for axially containing said wheels (14, 15), said containment bodies (19, 20) being associated with said housing and each comprising a first face (19a, 20a) which faces said pair of gearwheels (14, 15) and a second face (19b, 20b) which is axially opposite said first face (19a, 20a), - for each of said wheels (14, 15), a plurality of rolling bodies which form a crown and which are freely housed in an annular seat that is coaxial to the respective shaft (16, 18) and that is defined at the interface between said first face (19a, 20a) of at least one of said containment bodies (19, 20) and the surface (14a, 15a; 14b, 15b) of said wheels (14, 15) facing it, respectively in said first face (19a, 20a) of at least one of said containment bodies or in said surface (14a, 15a; 14b, 15b) of said gearwheels facing said first face (19a, 20a)
A curable composition, comprising: a crosslinked polysiloxane that has an average composition formula of Formula 1; a crosslinked polysiloxane that has an average composition formula of Formula 2; and a polysiloxane that has at least one hydrogen atom bound to the silicon atom, wherein the polysiloxane is comprised in an amount of 20 to 700 parts by weight, relative to 100 parts by weight of the polysiloxane: [Formula 1] (R 1 R 2 R 3 SiO 1/2) a (R 4 R 5 SiO 2/2) b (R 6 SiO 3/2) c (SiO 4/2) d [Formula 2] (R 7 R 8 R 9 SiO 1/2) e (R 1 R 11 SiO 2/2) f (R 12 SiO 3/2) g (SiO 4/2) h wherein R 1 to R 12 are independently an alkoxy group, a hydroxyl group, an epoxy group, or a monovalent hydrocarbon group, provided that at least one of R 1 to R 6 and at least one of R 7 to R 12 are the alkenyl groups, (a+b)/(a+b+c+d) is in the range from 0.7 to 0.97, c/(c+d) is in the range of 0.8 or more, (e+f)/(e+f+g+h) is in the range from 0.2 to 0.5, g/(g+h) is in the range of 0.7 or more, c and d are not 0 simultaneously, and g and h are not 0 simultaneously. a crosslinked polysiloxane that has an average composition formula of Formula 1; a crosslinked polysiloxane that has an average composition formula of Formula 2; and a polysiloxane that has at least one hydrogen atom bound to the silicon atom,
Thermally insulating curtain for windows of buildings and other rooms which are provided with glass or another transparent material, whereby the curtain has an outer dark, for instance black, solar energy absorbing surface towards the outside of a thermally insulating layer, and whereby a space (51, 11) is formed between said dark surface and a transparent layer situated towards the outside of the dark solar energy absorbing surface and/or between said dark solar energy absorbing surface and the thermally insulating layer of said curtain situated inward toward the room, and whereby the curtain having fastening members to allow arrangement of the curtain on the inside of a window, so that absorbed solar energy is supplied to the room behind the curtain, characterized in that there is a fan which is driven by electricity, solar cells and/or battery that allows transportation of air (14, 15, 16) through said space (51, 11) of the curtain, and in that the thermally insulating layer is formed of a plurality of textiles, sheets, or the like air partitions held at a mutual distance from each other and extending parallel to said dark solar energy absorbing surface, and in that the space (51, 11) between the dark solar energy absorbing surface and the transparent layer and/or an externally situated surface of the insulating layer facing said space (51, 11) is open all the way through, preferably from bottom to top or from top to bottom or from the side, and in that a thermostat is connected to control the fan, which thermostat detects the air temperature in said space (51, 11) and in the room, respectively, and in that a non-return valve is arranged, which prevents cold air from being conveyed into the room because of cold downdraught.