A computer-implemented method for processing angiography image data, the method comprising: importing angiography data including a plurality of angiography image frames, the angiography data being synchronized with cardiac phase signals such that each angiography image frame includes an associated cardiac phase signal; detecting an imaging catheter path for angiography image frames not including contrast media in a targeted area and saving the imaging catheter path with the associated cardiac phase signal for the angiography image frames not including contrast media in the targeted area; detecting a vessel contour and a marker for angiography image frames including contrast media in the targeted area and saving the vessel contour, the marker and the associated cardiac phase signal for the angiography image frames including contrast media in the targeted area; selecting an angiography image frame from the angiography image frames including contrast media and selecting an angiography image frame from the angiography image frames not including contrast media having identical cardiac phase signals; overlaying the angiography image frame from the angiography image frames including contrast media with the angiography image frame from the angiography image frames not including contrast media to determine whether the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media is located within the vessel contour of the angiography image frame from the angiography image frames including contrast media; and determining whether the marker associated with the angiography image frame from the angiography image frames including contrast media is located on the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media in response to a determination that the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media is located within the vessel contour of the angiography image frame from the angiography image frames including contrast media. importing angiography data including a plurality of angiography image frames, the angiography data being synchronized with cardiac phase signals such that each angiography image frame includes an associated cardiac phase signal; detecting an imaging catheter path for angiography image frames not including contrast media in a targeted area and saving the imaging catheter path with the associated cardiac phase signal for the angiography image frames not including contrast media in the targeted area; detecting a vessel contour and a marker for angiography image frames including contrast media in the targeted area and saving the vessel contour, the marker and the associated cardiac phase signal for the angiography image frames including contrast media in the targeted area; selecting an angiography image frame from the angiography image frames including contrast media and selecting an angiography image frame from the angiography image frames not including contrast media having identical cardiac phase signals; overlaying the angiography image frame from the angiography image frames including contrast media with the angiography image frame from the angiography image frames not including contrast media to determine whether the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media is located within the vessel contour of the angiography image frame from the angiography image frames including contrast media; and determining whether the marker associated with the angiography image frame from the angiography image frames including contrast media is located on the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media in response to a determination that the imaging catheter path of the angiography image frame from the angiography image frames not including contrast media is located within the vessel contour of the angiography image frame from the angiography image frames including contrast media.