mhurhangee/ep-ind-claims huggingface dataset:
A microchip comprising: a channel permitting a sheath liquid to flow there through: and a microtube disposed such that its center is located coaxially with a center of the channel and configured to introduce a laminar flow of a sample liquid via an opening of the microtube into a laminar flow of said sheath liquid flowing through said channel, whereby the laminar flow of said sample liquid introduced through said microtube is surrounded by said laminar flow of said sheath liquid, said channel having a narrow-down section in which its area in a section orthogonal to the liquid feed direction decreases gradually along the liquid feed direction; said sheath liquid laminar flow and said sample liquid laminar flow are made to pass while the laminar flow widths of said laminar flows are narrowed down in said narrow-down section after the opening of the microtube, characterized in that said narrow-down section has a configuration in which one of a channel bottom surface and a channel upper surface is formed as a surface having a stairway-like shape with a plurality of steps, whereby said sheath liquid laminar flow and said sample liquid laminar flow are made to pass while being deflected toward the upper side or the lower side of the microchip, and channel side walls of the narrow-down section are formed as surfaces having a stairway-like shape with a plurality of steps, whereby said sheath liquid laminar flow and said sample liquid laminar flow are isotropically reduced and narrowed down. a channel permitting a sheath liquid to flow there through: and a microtube disposed such that its center is located coaxially with a center of the channel and configured to introduce a laminar flow of a sample liquid via an opening of the microtube into a laminar flow of said sheath liquid flowing through said channel, whereby the laminar flow of said sample liquid introduced through said microtube is surrounded by said laminar flow of said sheath liquid, said channel having a narrow-down section in which its area in a section orthogonal to the liquid feed direction decreases gradually along the liquid feed direction; said sheath liquid laminar flow and said sample liquid laminar flow are made to pass while the laminar flow widths of said laminar flows are narrowed down in said narrow-down section after the opening of the microtube, characterized in that said narrow-down section has a configuration in which one of a channel bottom surface and a channel upper surface is formed as a surface having a stairway-like shape with a plurality of steps, whereby said sheath liquid laminar flow and said sample liquid laminar flow are made to pass while being deflected toward the upper side or the lower side of the microchip, and channel side walls of the narrow-down section are formed as surfaces having a stairway-like shape with a plurality of steps, whereby said sheath liquid laminar flow and said sample liquid laminar flow are isotropically reduced and narrowed down.
A passive crush prevention profile for closing edges, with an asymmetrical internal functional geometry, wherein the internal functional geometry is formed by a holding crosspiece and a folding crosspiece between a base and a front, wherein the folding crosspiece is arranged asymmetrically to the holding crosspiece between the base and the front, wherein the folding crosspiece has a functional articulation (8, 9) in each case at its end, wherein the holding crosspiece and the folding crosspiece together with the side wall, the further side wall, the base and the front form chambers formed asymmetrically to each other, namely a side chamber, a further side chamber and a middle chamber, characterised in that the side walls (12, 13) of the crush prevention profile in each case have a side articulation (6, 7).
A vehicle comprising: a coolant header tank defining a storage volume for storing a fluid coolant and having a minimum fluid level within the storage volume, the coolant header tank comprising a first port connected to the portion of the storage volume that contains fluid when filled to the minimum fluid level and a third port connected to the portion of the storage volume that contains fluid when filled to the minimum fluid level; and a temperature regulating system configured to carry the fluid coolant, the temperature regulating circuit comprising: a cooling circuit configured to carry the fluid coolant; a branch connected between an air collecting region (18,19) of the temperature regulating system and the first port of the coolant header tank to permit air to flow from the temperature regulating system to the coolant header tank, the temperature regulating system being configured so that the air collecting region is higher than a horizontal plane that is defined by the minimum fluid level; and a coolant feed branch connected between the third port and the cooling circuit to permit fluid to flow between the coolant header tank and the cooling circuit. a coolant header tank defining a storage volume for storing a fluid coolant and having a minimum fluid level within the storage volume, the coolant header tank comprising a first port connected to the portion of the storage volume that contains fluid when filled to the minimum fluid level and a third port connected to the portion of the storage volume that contains fluid when filled to the minimum fluid level; and a temperature regulating system configured to carry the fluid coolant, the temperature regulating circuit comprising: a cooling circuit configured to carry the fluid coolant; a branch connected between an air collecting region (18,19) of the temperature regulating system and the first port of the coolant header tank to permit air to flow from the temperature regulating system to the coolant header tank, the temperature regulating system being configured so that the air collecting region is higher than a horizontal plane that is defined by the minimum fluid level; and a coolant feed branch connected between the third port and the cooling circuit to permit fluid to flow between the coolant header tank and the cooling circuit. a cooling circuit configured to carry the fluid coolant; a branch connected between an air collecting region (18,19) of the temperature regulating system and the first port of the coolant header tank to permit air to flow from the temperature regulating system to the coolant header tank, the temperature regulating system being configured so that the air collecting region is higher than a horizontal plane that is defined by the minimum fluid level; and a coolant feed branch connected between the third port and the cooling circuit to permit fluid to flow between the coolant header tank and the cooling circuit.
A process for the production of composite materials comprising nano-fibrillar cellulose gels, characterized by the steps of: a) providing cellulose fibres; b) providing at least one filler and/or pigment; c) combining the cellulose fibres of step a) and the at least one filler and/or pigment of step b); d) fibrillating the cellulose fibres in an aqueous environment in the presence of the at least one filler and/or pigment until a nano-fibrillar cellulose gel is formed, wherein the formation of the gel is verified by monitoring the viscosity of the mixture in dependence of the shearing rate, wherein the viscosity decrease of the mixture upon step-wise increase of the shearing rate is stronger than the corresponding viscosity increase upon subsequent step-wise reduction of the shearing rate over at least part of the shear rate range as shearing approaches zero; e) providing at least one further filler and/or pigment; f) combining the gel of step d) with the at least one further filler and/or pigment of step e). a) providing cellulose fibres; b) providing at least one filler and/or pigment; c) combining the cellulose fibres of step a) and the at least one filler and/or pigment of step b); d) fibrillating the cellulose fibres in an aqueous environment in the presence of the at least one filler and/or pigment until a nano-fibrillar cellulose gel is formed, wherein the formation of the gel is verified by monitoring the viscosity of the mixture in dependence of the shearing rate, wherein the viscosity decrease of the mixture upon step-wise increase of the shearing rate is stronger than the corresponding viscosity increase upon subsequent step-wise reduction of the shearing rate over at least part of the shear rate range as shearing approaches zero; e) providing at least one further filler and/or pigment; f) combining the gel of step d) with the at least one further filler and/or pigment of step e).
An aqueous liquid pharmaceutical formulation of an antibody-drug conjugate, wherein the formulation comprises the antibody-drug conjugate, a non-reducing sugar, an amino acid, and a solubilizer, the non-reducing sugar is selected from mannitol, sucrose, and a combination thereof, the amino acid is selected from histidine, histidine hydrochloride, and a combination thereof, and the solubilizer is polysorbate 80; wherein the antibody-drug conjugate is an anti-HER2 monoclonal antibody and the drug is MMAE, and wherein the antibody of the antibody-drug conjugate comprises a heavy chain and a light chain, the heavy chain comprises CDRs 1-3 having amino acid sequences as shown in SEQ ID NO: 1, 2 and 3, respectively, and wherein the light chain comprises CDRs 1-3 having amino acid sequences as shown in SEQ ID NO: 4, 5 and 6, respectively. the formulation comprises the antibody-drug conjugate, a non-reducing sugar, an amino acid, and a solubilizer, the non-reducing sugar is selected from mannitol, sucrose, and a combination thereof, the amino acid is selected from histidine, histidine hydrochloride, and a combination thereof, and the solubilizer is polysorbate 80; wherein the antibody-drug conjugate is an anti-HER2 monoclonal antibody and the drug is MMAE, and wherein the antibody of the antibody-drug conjugate comprises a heavy chain and a light chain, the heavy chain comprises CDRs 1-3 having amino acid sequences as shown in SEQ ID NO: 1, 2 and 3, respectively, and wherein the light chain comprises CDRs 1-3 having amino acid sequences as shown in SEQ ID NO: 4, 5 and 6, respectively.
Inspection vehicle for under water inspection of coating, marine growth, structural integrity and corrosion on ferromagnetic ship hulls and other ferromagnetic structures wherein the inspection vehicle comprises: a non-magnetic element, at least one magnetic wheel or magnetic device operatively arranged to the element, and a watertight camera for visual inspection attached to the element or other structure of the inspection vehicle, one coupling side where the at least one magnetic wheel or device is operatively arranged for the inspection vehicle to couple magnetically through coating, any marine growth and corrosion products and allow rolling the inspection vehicle on said structure, in horizontal to vertical to upside down-orientation while holding the inspection vehicle attached to the structure, and one non-coupling side oriented in substance in opposite direction to the coupling side, where the at least one magnetic wheel or device is not operatively arranged and the non-coupling side will not couple magnetically to said structure, wherein the inspection vehicle further comprises a combination of an induction-based sensor and an ultrasound-based sensor, characterised in that the combination of an induction-based sensor and an ultrasound-based sensor is adapted to measure lift-off from the ferromagnetic structure being inspected, coating thickness and quality, thickness and type of marine growth and thickness of ferromagnetic wall or hull. a non-magnetic element, at least one magnetic wheel or magnetic device operatively arranged to the element, and a watertight camera for visual inspection attached to the element or other structure of the inspection vehicle, one coupling side where the at least one magnetic wheel or device is operatively arranged for the inspection vehicle to couple magnetically through coating, any marine growth and corrosion products and allow rolling the inspection vehicle on said structure, in horizontal to vertical to upside down-orientation while holding the inspection vehicle attached to the structure, and one non-coupling side oriented in substance in opposite direction to the coupling side, where the at least one magnetic wheel or device is not operatively arranged and the non-coupling side will not couple magnetically to said structure, wherein the inspection vehicle further comprises a combination of an induction-based sensor and an ultrasound-based sensor, characterised in that the combination of an induction-based sensor and an ultrasound-based sensor is adapted to measure lift-off from the ferromagnetic structure being inspected, coating thickness and quality, thickness and type of marine growth and thickness of ferromagnetic wall or hull.
An induction heating system for part manufacturing, the induction heating system comprising: an induction coil capable of generating an oscillating electromagnetic field; characterised in that the induction heating system further comprises: a susceptor positioned to be in the oscillating electromagnetic field when said induction coil is energized, the susceptor comprising: a sheet metal component formed to a desired shape by incremental sheet forming; and a ferromagnetic material cold sprayed onto the sheet metal component. characterised in that the induction heating system further comprises: a susceptor positioned to be in the oscillating electromagnetic field when said induction coil is energized, the susceptor comprising: a sheet metal component formed to a desired shape by incremental sheet forming; and a ferromagnetic material cold sprayed onto the sheet metal component. a sheet metal component formed to a desired shape by incremental sheet forming; and a ferromagnetic material cold sprayed onto the sheet metal component.
Engine for a flying body, having an annular vortex guide element which, seen in section, has an air inlet opening arranged centrally with respect to a longitudinal central axis of the engine and, at a distance from the air inlet opening, an air outlet opening arranged centrally with respect to the longitudinal central axis, which are connected to one another in terms of flow via an intake duct which is bounded by the vortex guide element and accommodates an air conveying device, wherein the air outlet opening is overlapped by an air deflecting element which is arranged geodetically above the vortex guide element when the engine is operating as intended, which extends radially outwards from the air outlet opening so that, together with the vortex guide element, it delimits an air exit gap which is in flow communication with the air outlet opening, wherein the vortex guide element is in the form of a body of rotation which is formed by rotation about an axis of rotation of a closed curve continuously comprising a continuous course at least on its radially outer side, characterised in that the air inlet opening opens directly into an outer environment of the engine, so that a free air space is present in an imaginary extension of the intake duct on the side of the air inlet opening and, when the engine is operating as intended, air is conveyed from the side of the engine facing away from the air deflecting element through the air inlet opening directly from the outer environment into the intake duct.
A composition comprising Dikkopf 2 or an active fragment thereof for use in treating injury in a kidney or pancreas, comprising administering a therapeutically effective amount of said composition; wherein the active fragment of Dkk2 comprises the C-terminal cysteine-rich domain that binds to and activates LRP5/6 and/or comprises amino acids Met172-Ile259 of mouse Dkk2 or a human homolog thereof.
A method for purification of insulin from pro-insulin comprising the following steps: loading a sample of cleaved pro-insulin on a chromatography medium comprising porous shell beads having an inner core and an outer funtionalized layer provided with ion exchange ligands; adsorbing insulin on the ligands; and eluting insulin from the chromatography medium at a flow rate of 100-1000 cm/h, preferably 300-600 cm/h, wherein the eluted insulin has a purity of more than 85%, preferably more than 90%. loading a sample of cleaved pro-insulin on a chromatography medium comprising porous shell beads having an inner core and an outer funtionalized layer provided with ion exchange ligands; adsorbing insulin on the ligands; and eluting insulin from the chromatography medium at a flow rate of 100-1000 cm/h, preferably 300-600 cm/h, wherein the eluted insulin has a purity of more than 85%, preferably more than 90%.
A drive control equipment for a vehicle comprising: a plurality of power conversion devices respectively connected to a plurality of motors provided in a vehicle, configured to convert a DC power that is supplied from a DC power source to AC power and output the AC power to the motors; a control device configured to control said power conversion devices; characterized by a frame, having a ceiling wall facing a floor of the vehicle, a bottom wall facing a ground, and a sidewall connecting the ceiling wall and the bottom wall, configured to accommodate the power conversion devices and the control device; and a power unit having a cooler in which are mounted a plurality of semiconductor elements constituting the power conversion devices, a first control board having a first connector connected with the semiconductor elements, arranged facing the cooler, and a second control board having a second connector directly connected with the first connector of the first control board, arranged a direction orthogonal to the first control board. a plurality of power conversion devices respectively connected to a plurality of motors provided in a vehicle, configured to convert a DC power that is supplied from a DC power source to AC power and output the AC power to the motors; a control device configured to control said power conversion devices; characterized by a frame, having a ceiling wall facing a floor of the vehicle, a bottom wall facing a ground, and a sidewall connecting the ceiling wall and the bottom wall, configured to accommodate the power conversion devices and the control device; and a power unit having a cooler in which are mounted a plurality of semiconductor elements constituting the power conversion devices, a first control board having a first connector connected with the semiconductor elements, arranged facing the cooler, and a second control board having a second connector directly connected with the first connector of the first control board, arranged a direction orthogonal to the first control board.
Recombinant strain of Mycobacterium bovis Bacillus Calmette Guerin characterized in that it expresses a mutant Escherichia coli heat-labile toxin LT mutated at position 63, or a mutant A subunit thereof, and the mutation is a substitution of serine by lysine, for use as a medicament for preventing or treating disease and/or infections caused by bacteria of the genus Mycobacterium in animals.
A device for vibration stimulation in at least one nasal cavity of a human subject, comprising a first stimulation member arranged to be introducible into a first nasal cavity, to be expanded within the first nasal cavity and to abut against tissue in the first nasal cavity; a first expansion member arranged to expand the first stimulation member; the first expansion member comprising a first tubular structure arranged at least partly within the first stimulation member, wherein the first tubular structure is provided with a plurality of openings arranged for fluid communication with the stimulation member; a second stimulation member arranged to be introducible into a second nasal cavity, to be expanded within the second nasal cavity and to abut against tissue in the second nasal cavity, and a second expansion member arranged to expand the second stimulation member; the second expansion member comprising a second tubular structure arranged at least partly within the second stimulation member, wherein the second tubular structure is provided with a plurality of openings 20 arranged for fluid communication with the second stimulation member; wherein the device comprises at least one anchoring member; wherein the first and second expansion members are partly provided within an outer tubing, a cuff is attached to the outer tubing, wherein the cuff comprises a ball adapted to snuggly fit into a corresponding interface on a support arm, the support arm is connected to the anchoring member, wherein the anchoring member is arranged to secure the first and second stimulation members in fixed positions in the first and second nasal cavities during vibration stimulation in at least one nasal cavity; wherein at least one of the first and second stimulation members is arranged to impart vibrations to tissue in at least one nasal cavity.
A heating device comprising a burner (1, 10), wherein the burner (1, 10) comprises: a main burner part having a fuel gas nozzle configured to discharge fuel gas and an air nozzle configured to discharge air for combustion; and a sub burner part positioned further outward than the main burner part and configured to combust the fuel gas discharged from the main burner part, wherein the burner (1, 10) further comprises at its end a recessed part having a bottom part and a tapered part, characterized in that the tapered part is gradually widening from the bottom part to the end of the burner (1, 10), wherein the main burner part is disposed on the bottom part, and wherein the sub burner part is disposed on the tapered part and in that an intersection point of a gas discharge direction of the main burner part and the gas discharge direction of the sub burner part is disposed in an outer side of the recessed part of the burner (1, 10). a main burner part having a fuel gas nozzle configured to discharge fuel gas and an air nozzle configured to discharge air for combustion; and a sub burner part positioned further outward than the main burner part and configured to combust the fuel gas discharged from the main burner part, wherein the burner (1, 10) further comprises at its end a recessed part having a bottom part and a tapered part, characterized in that the tapered part is gradually widening from the bottom part to the end of the burner (1, 10), wherein the main burner part is disposed on the bottom part, and wherein the sub burner part is disposed on the tapered part and in that an intersection point of a gas discharge direction of the main burner part and the gas discharge direction of the sub burner part is disposed in an outer side of the recessed part of the burner (1, 10).
A system for non-invasive data acquisition from a human or animal body, comprising an antenna (3,4) for irradiating the skin of said body, said antenna (3, 4) being connected to a source and a processor, the processor being configured for collecting said data from reflections of said irradiation, wherein the antenna (3, 4) is a leaky wave antenna operable using a dielectric layer, the system being configured so that the skin of the body is used for at least partially forming said dielectric layer.