mhurhangee/ep-ind-claims huggingface dataset:
A bispecific tetravalent antibody, said bispecific tetravalent antibody comprising: a first IgG1 heavy chain, connector, and single chain Fv (scFv) domain polypeptide comprising SEQ ID NO: 136; a second IgG1 heavy chain, connector, and scFv domain polypeptide comprising SEQ ID NO: 136; a first kappa light chain polypeptide comprising SEQ ID NO: 131; and a second kappa light chain polypeptide comprising SEQ ID NO: 131; wherein the first and second IgG1 heavy chains and the first and second kappa light chains form an IgG moiety with a binding specificity for EGFR; and wherein the first and second scFv domains each have a binding specificity for HER3. a first IgG1 heavy chain, connector, and single chain Fv (scFv) domain polypeptide comprising SEQ ID NO: 136; a second IgG1 heavy chain, connector, and scFv domain polypeptide comprising SEQ ID NO: 136; a first kappa light chain polypeptide comprising SEQ ID NO: 131; and a second kappa light chain polypeptide comprising SEQ ID NO: 131; wherein the first and second IgG1 heavy chains and the first and second kappa light chains form an IgG moiety with a binding specificity for EGFR; and wherein the first and second scFv domains each have a binding specificity for HER3.
An adhesive tape comprising an adhesive layer containing an adhesive composition, wherein: the adhesive composition contains a styrene-butadiene-based block copolymer, a first tackifier, a second tackifier, and a third tackifier; a butadiene portion of the styrene-butadiene-based block copolymer is partially hydrogenated; the first tackifier is at least one of a rosin ester which is liquid at 23°C and a terpene-based resin which is liquid at 23°C; the second tackifier has a softening point of 70 to 120°C, measured in accordance with the softening point test method (ring and ball method) stipulated in JIS K5902 and JIS K2207; the third tackifier has a softening point of 140°C or higher; holding force of the adhesive tape at 70°C based on JIS Z0237 is 100 minutes or more; and a melt viscosity of the adhesive composition at 200°C is 100000 mPa.s (cp) or lower, measured using a rheometer at 200°C and at a shear rate of 10 (1/s); a content of the styrene-butadiene-based block copolymer is 45 to 55 parts by mass; a content of the first tackifier is 5 to 15 parts by mass; a content of the second tackifier is 10 or more parts by mass; and a total content of the second tackifier and the third tackifier is 30 to 50 parts by mass, per 100 parts by mass of the adhesive composition. the adhesive composition contains a styrene-butadiene-based block copolymer, a first tackifier, a second tackifier, and a third tackifier; a butadiene portion of the styrene-butadiene-based block copolymer is partially hydrogenated; the first tackifier is at least one of a rosin ester which is liquid at 23°C and a terpene-based resin which is liquid at 23°C; the second tackifier has a softening point of 70 to 120°C, measured in accordance with the softening point test method (ring and ball method) stipulated in JIS K5902 and JIS K2207; the third tackifier has a softening point of 140°C or higher; holding force of the adhesive tape at 70°C based on JIS Z0237 is 100 minutes or more; and a melt viscosity of the adhesive composition at 200°C is 100000 mPa.s (cp) or lower, measured using a rheometer at 200°C and at a shear rate of 10 (1/s); a content of the styrene-butadiene-based block copolymer is 45 to 55 parts by mass; a content of the first tackifier is 5 to 15 parts by mass; a content of the second tackifier is 10 or more parts by mass; and a total content of the second tackifier and the third tackifier is 30 to 50 parts by mass, per 100 parts by mass of the adhesive composition.
A device for packaging medication portions, having a frame structure, on which at least one guide unit is fastened, wherein the guide unit has a plurality of receptacle openings and at least one dispensing opening, a plurality of storage and dispensing stations for dispensing individual medication portions, wherein the storage and dispensing stations have a supply store for medication portions and a dispensing station having a medication dispensing channel for dispensing individual medication portions, at least one holding unit for storage and dispensing stations, wherein the holding unit has a plurality of mounts, in each of which a medication slide having a receptacle opening and a dispensing opening and a storage and dispensing station are arranged such that the receptacle openings of the medication slides are associated with the medication dispensing channels of the dispensing stations and the dispensing openings of the medication slides are associated with the receptacle openings of the at least one guide unit, at least one collecting device for receiving medication portions from the at least one guide unit and relaying them to a packaging device, which packages the provided medication portions, characterized in that the at least one guide unit is removably arranged on the frame structure and the at least one holding unit and the frame structure are fastened on or in the device such that the holding unit and the frame structure are movable relative to one another such that the at least one guide unit can be accessed from outside the device in an access position.
Moulded article comprising or consisting of A) a rigid foam granulate; and B) a flexible foam matrix, characterized in that the moulded article has a thermal conductivity of 0.020 to 0.035 W/(m*K) determined according to DIN EN 13165:2016-09 and the rigid foam granulate A) consists of one or more polymer foam granulates selected from rigid polyurethane foam granulate, polyisocyanurate foam granulate, phenolic foam granulate or mixtures thereof, wherein the rigid foam granulate A) comprises less than 200 open cells measured as specified in the description. A) a rigid foam granulate; and B) a flexible foam matrix, the moulded article has a thermal conductivity of 0.020 to 0.035 W/(m*K) determined according to DIN EN 13165:2016-09 and the rigid foam granulate A) consists of one or more polymer foam granulates selected from rigid polyurethane foam granulate, polyisocyanurate foam granulate, phenolic foam granulate or mixtures thereof, wherein the rigid foam granulate A) comprises less than 200 open cells measured as specified in the description.
A sealing assembly for prevention of ingress of particulates and water into an electrical switch having two or more positions moveable between a first extremity and a second extremity in a linear direction of movement by an actuator, whereby said actuator is operable through an aperture extending through the outer surface of a housing of the electrical switch, said sealing assembly comprising: an engagement element including a rigid first abutment portion for circumscribing the aperture extending through the outer surface of the housing of the switch and a rigid first retention portion; a sealing element being slidingly engageable with the engagement element in a direction of said linear direction of movement of the actuator and being retained by the retention portion of the engagement element, said sealing element including a first complementary abutment portion for sliding engagement with the first abutment portion of the engagement element; wherein the sealing element is formed from an elastically resilient polymeric material such that when retained by the engagement element, sealing engagement between the first complementary abutment portion of the sealing element and the first abutment portion is effected as the first complementary abutment portion is urged against the first abutment surface of the engagement element so as to occlude passage and ingress of particulates and water from external of the first abutment portion to the aperture extending through the outer surface of a housing of the electrical switch; wherein upon movement of the sealing element in conjunction with movement of the actuator of the electrical switch between the first extremity and the second extremity, said sealing engagement between the first complementary abutment portion of the sealing element and the first abutment surface of the engagement element is maintained; and wherein the sealing assembly is characterised in that the retention portion of the engagement element is provided as a rail assembly which protrudes from and extends in a direction of outwardly away from the outer surface of the housing. an engagement element including a rigid first abutment portion for circumscribing the aperture extending through the outer surface of the housing of the switch and a rigid first retention portion; a sealing element being slidingly engageable with the engagement element in a direction of said linear direction of movement of the actuator and being retained by the retention portion of the engagement element, said sealing element including a first complementary abutment portion for sliding engagement with the first abutment portion of the engagement element;
A method for enhancing the operation and improving the effectiveness of an air filtration system in a building air circulation system having motorized blower motor and a contamination filter, the method characterized by comprising: predicting a cost of operation of the circulation system over an operational duration based on at least an electricity consumption associated with operation of the blower motor and an operational cost to operate the contamination filter; predicting a cost of maintenance of the circulation system over the operational duration based on at least one of, an operational condition of the contamination filter, a cost of a replacement contamination filter, a cost of labor to clean or replace the contamination filter, and an effectiveness of the contamination filter over the operational duration; and balancing the cost of operation of the circulation system versus the cost of maintenance of the circulation system over the selected operational duration to recommend at least one of a contamination filter use/bypass schedule, a contamination filter maintenance schedule, and a fresh air input schedule satisfying an operation objective and an operational constraint set by an operator. predicting a cost of operation of the circulation system over an operational duration based on at least an electricity consumption associated with operation of the blower motor and an operational cost to operate the contamination filter; predicting a cost of maintenance of the circulation system over the operational duration based on at least one of, an operational condition of the contamination filter, a cost of a replacement contamination filter, a cost of labor to clean or replace the contamination filter, and an effectiveness of the contamination filter over the operational duration; and balancing the cost of operation of the circulation system versus the cost of maintenance of the circulation system over the selected operational duration to recommend at least one of a contamination filter use/bypass schedule, a contamination filter maintenance schedule, and a fresh air input schedule satisfying an operation objective and an operational constraint set by an operator.
Device for homogenising a product, wherein the device has a hydraulic drive cylinder with at least one piston rod and a homogenisation means, wherein in each case a product tube (111, 113) is arranged on either side of the hydraulic drive cylinder and in each case a product piston (107, 109) which is movable in the respective product tube is arranged at both ends of the at least one piston rod, each product tube comprises an inlet and an outlet for the product and the homogenisation means is arranged behind the two outlets, wherein the hydraulic drive cylinder is formed as a double-acting through-rod cylinder, so that the at least one piston rod is movable in the same manner in two opposite directions, wherein expulsion of the product out of the one product tube via the outlet thereof and receiving of the product in the other product tube via the inlet thereof takes place by a movement of the respective product piston by means of the at least one piston rod, and upon expulsion via the outlet the product is forced against a counter-pressure of the homogenisation means such that homogenisation of the product takes place, characterised in that the homogenisation means has a cavitation means and the cavitation means has a vacuum means, so that at the exit from a pressure-relief chamber of the cavitation means a vacuum can be applied by means of the vacuum means when pumping out the homogenised product.
A temperature sensor comprising: ▪ a capacitive circuit comprising an input terminal for the application of an input voltage, an output terminal for the reading of an output voltage of the circuit, and a reference potential terminal (16, 18); ▪ a voltage circuit for applying a predetermined voltage to the input terminal of the circuit; and ▪ a circuit for reading the voltage at the output terminal of the capacitive circuit and converting the read voltage into a temperature measurement, characterized in that the capacitive circuit comprises: ▪ a first capacitor, connected between the input and output terminals, and having a capacitance decreasing according to temperature; and ▪ a second capacitor, connected between the input terminal and the terminal at the reference potential, and having a capacitance increasing along with temperature. ▪ a capacitive circuit comprising an input terminal for the application of an input voltage, an output terminal for the reading of an output voltage of the circuit, and a reference potential terminal (16, 18); ▪ a voltage circuit for applying a predetermined voltage to the input terminal of the circuit; and ▪ a circuit for reading the voltage at the output terminal of the capacitive circuit and converting the read voltage into a temperature measurement, ▪ a first capacitor, connected between the input and output terminals, and having a capacitance decreasing according to temperature; and ▪ a second capacitor, connected between the input terminal and the terminal at the reference potential, and having a capacitance increasing along with temperature.
A computer-implemented method of acquiring a fingerprint image from a fingerprint sensor with an array of sensor elements spanning a sensing area, comprising: - monitoring groups (110; 111; 114) of sensor elements located at group-wise spaced apart positions in the array of sensor elements, to determine the location of a touch occurring on the array of sensor elements; - from the array of sensor elements, acquiring, at respective points in time, fingerprint sub-images which are confined in size to a subarea of the sensing area; wherein one or more of the sub-images is/are selected from a location about the location of the touch; - as the fingerprint sub-images are acquired, computing values of a statistical indicator from the fingerprint sub-images, the statistical indicator being selected from the group of: a percentile or quantile of a distribution of intensity values in the sub-images; a median value, a mean value, a total variation distance, and a divergence measure, such as an asymmetrical or symmetrical divergence measure of the distribution relative to a predefined distribution; - evaluating the slope of the values of the statistical indicator over time as the values are computed; and - acquiring a full fingerprint image when the slope is below a predefined slope threshold. - monitoring groups (110; 111; 114) of sensor elements located at group-wise spaced apart positions in the array of sensor elements, to determine the location of a touch occurring on the array of sensor elements; - from the array of sensor elements, acquiring, at respective points in time, fingerprint sub-images which are confined in size to a subarea of the sensing area; wherein one or more of the sub-images is/are selected from a location about the location of the touch; - as the fingerprint sub-images are acquired, computing values of a statistical indicator from the fingerprint sub-images, the statistical indicator being selected from the group of: a percentile or quantile of a distribution of intensity values in the sub-images; a median value, a mean value, a total variation distance, and a divergence measure, such as an asymmetrical or symmetrical divergence measure of the distribution relative to a predefined distribution; - evaluating the slope of the values of the statistical indicator over time as the values are computed; and - acquiring a full fingerprint image when the slope is below a predefined slope threshold.
A computer-implemented method of creating a route set for an aircraft to travel through an airspace, the method comprising: generating the route set comprising routes that each extend through the airspace and each comprises a different flight path through the airspace; ranking the routes based on one or more objectives and constraints; deleting from the route set one or more of the routes that rank below a predetermined threshold; determining that the route set is incomplete after deleting the one or more routes and generating additional routes based on the one or more objectives and constraints; supplementing the route set with the additional routes that rank above the predetermined threshold; and selecting one of the routes from the route set for the aircraft to travel while flying through the airspace, wherein generating the route set comprises: creating parent routes that each extend through the airspace; assigning one or more waypoints to each of the parent routes; varying the parent routes at one or more of the waypoints to create new child routes that extend through the airspace and that are different than the parent routes; and populating the route set with both the parent routes and the child routes as routes of the route set. generating the route set comprising routes that each extend through the airspace and each comprises a different flight path through the airspace; ranking the routes based on one or more objectives and constraints; deleting from the route set one or more of the routes that rank below a predetermined threshold; determining that the route set is incomplete after deleting the one or more routes and generating additional routes based on the one or more objectives and constraints; supplementing the route set with the additional routes that rank above the predetermined threshold; and selecting one of the routes from the route set for the aircraft to travel while flying through the airspace, wherein generating the route set comprises: creating parent routes that each extend through the airspace; assigning one or more waypoints to each of the parent routes; varying the parent routes at one or more of the waypoints to create new child routes that extend through the airspace and that are different than the parent routes; and populating the route set with both the parent routes and the child routes as routes of the route set. creating parent routes that each extend through the airspace; assigning one or more waypoints to each of the parent routes; varying the parent routes at one or more of the waypoints to create new child routes that extend through the airspace and that are different than the parent routes; and populating the route set with both the parent routes and the child routes as routes of the route set.
Method of determining a subset of diagnostic markers for potentially methylated genes from the genes of gene marker IDs 1-359 of table 1, suitable for the diagnosis or prognosis of a disease or tumor type in a sample, comprising a) obtaining data of the methylation status of at least 50 random genes selected from the 359 genes of gene marker IDs 1-359 in at least 1 sample, preferably 2, 3, 4 or at least 5 samples, of a confirmed disease or tumor type positive state and at least one sample of a disease or tumor type negative state, b) correlating the results of the obtained methylation status with the disease or tumor type, c) optionally repeating the obtaining a) and correlating b) steps for a different combination of at least 50 random genes selected from the 359 genes of gene marker IDs 1-359 and d) selecting as many marker genes which in a classification analysis have a p-value of less than 0.1 in a random-variance t-test, or selecting as many marker genes which in a classification analysis together have a correct disease or tumor type prediction of at least 70% in a cross-validation test; with the proviso that no more than 20 marker genes are selected in step d), wherein the selected markers form the subset of diagnostic markers. a) obtaining data of the methylation status of at least 50 random genes selected from the 359 genes of gene marker IDs 1-359 in at least 1 sample, preferably 2, 3, 4 or at least 5 samples, of a confirmed disease or tumor type positive state and at least one sample of a disease or tumor type negative state, b) correlating the results of the obtained methylation status with the disease or tumor type, c) optionally repeating the obtaining a) and correlating b) steps for a different combination of at least 50 random genes selected from the 359 genes of gene marker IDs 1-359 and d) selecting as many marker genes which in a classification analysis have a p-value of less than 0.1 in a random-variance t-test, or selecting as many marker genes which in a classification analysis together have a correct disease or tumor type prediction of at least 70% in a cross-validation test; with the proviso that no more than 20 marker genes are selected in step d),
A composition comprising, by weight percent: Cobalt (Co) between about 4.5 and about 7.0; Chromium (Cr) between about 10.2 and about 11.5; Molybdenum (Mo) between about 0.5 and about 2.5; Tungsten between about 4.0 and about 5.5; Rhenium (Re) between about 0 and about 1.2; Aluminum (Al) between about 6.2 and about 6.8; Tantalum (Ta) between about 4.5 and about 6.0; Titanium (Ti) between about 0 and about 0.5; Hafnium (Hf) between about 0 and about 0.5; Carbon between about 0 and about 0.2; Boron between about 0 and about 0.02; and optionally at least one of: up to about 20 ppm by weight rare earth or lanthanide elements and about less than 1 ppm by weight Sulphur, wherein the balance is Nickel (Ni), and other incidental impurities. Cobalt (Co) between about 4.5 and about 7.0; Chromium (Cr) between about 10.2 and about 11.5; Molybdenum (Mo) between about 0.5 and about 2.5; Tungsten between about 4.0 and about 5.5; Rhenium (Re) between about 0 and about 1.2; Aluminum (Al) between about 6.2 and about 6.8; Tantalum (Ta) between about 4.5 and about 6.0; Titanium (Ti) between about 0 and about 0.5; Hafnium (Hf) between about 0 and about 0.5; Carbon between about 0 and about 0.2; Boron between about 0 and about 0.02; and optionally at least one of: up to about 20 ppm by weight rare earth or lanthanide elements and about less than 1 ppm by weight Sulphur, wherein the balance is Nickel (Ni), and other incidental impurities.