mhurhangee/ep-ind-claims huggingface dataset:
A method of detecting a disease state in a subject, comprising: (a) providing a biological sample obtained from the subject; (b) contacting the sample with a sensor array, wherein the sensor array comprises a plurality of sensor elements that differ from each other in at least one physicochemical property; and wherein each sensor element binds a plurality of biomolecules in the sample to produce a plurality of biomolecule corona signatures forming distinct biomolecule corona signatures from each other based on the physicochemical property of each sensor element; and (c) determining a combined composition of a first biomolecule corona signature of the plurality of biomolecule corona signatures and a second biomolecule corona signature of the plurality of biomolecule corona signatures to produce a biomolecule fingerprint associated with the sample, wherein the biomolecule fingerprint differentiates the disease state of the subject. (a) providing a biological sample obtained from the subject; (b) contacting the sample with a sensor array, wherein the sensor array comprises a plurality of sensor elements that differ from each other in at least one physicochemical property; and wherein each sensor element binds a plurality of biomolecules in the sample to produce a plurality of biomolecule corona signatures forming distinct biomolecule corona signatures from each other based on the physicochemical property of each sensor element; and (c) determining a combined composition of a first biomolecule corona signature of the plurality of biomolecule corona signatures and a second biomolecule corona signature of the plurality of biomolecule corona signatures to produce a biomolecule fingerprint associated with the sample, wherein the biomolecule fingerprint differentiates the disease state of the subject.
A system for assessing decongestive therapy delivered to a heart failure patient, comprising: an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status responsive to delivery of the decongestive therapy; and a processor coupled to the implantable sensor, the processor configured to: determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient; determine (108, 208) if the patient is being subject to overtherapeuting by detection of over-diuresis of the patient; produce a first output (208, 302) in response to determining that the target level of patient diuresis has been achieved; and produce a second output in response to determining that the patient is being subject to over-therapeuting, wherein the second output comprises an alert indicating detection of over-diuresis of the patient. an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status responsive to delivery of the decongestive therapy; and a processor coupled to the implantable sensor, the processor configured to: determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient; determine (108, 208) if the patient is being subject to overtherapeuting by detection of over-diuresis of the patient; produce a first output (208, 302) in response to determining that the target level of patient diuresis has been achieved; and produce a second output in response to determining that the patient is being subject to over-therapeuting, wherein the second output comprises an alert indicating detection of over-diuresis of the patient. determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient; determine (108, 208) if the patient is being subject to overtherapeuting by detection of over-diuresis of the patient; produce a first output (208, 302) in response to determining that the target level of patient diuresis has been achieved; and produce a second output in response to determining that the patient is being subject to over-therapeuting, wherein the second output comprises an alert indicating detection of over-diuresis of the patient.
A blood processing filter for removing undesirable components from liquid containing a blood component or blood, the filter comprising: a sheet-shaped filter element; and a container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a pair of filtering surfaces disposed on the inlet space side and the outlet space side, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses outer edge portions of the pair of filtering surfaces and adheres to the end surface with melt resin, and a part of the container is provided with a steam-permeable portion having steam permeability, wherein said steam-permeable portion is a thin-walled portion that is thinner than other portions. a sheet-shaped filter element; and a container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a pair of filtering surfaces disposed on the inlet space side and the outlet space side, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses outer edge portions of the pair of filtering surfaces and adheres to the end surface with melt resin, and a part of the container is provided with a steam-permeable portion having steam permeability, wherein said steam-permeable portion is a thin-walled portion that is thinner than other portions.
An absorbent structure for an absorbent article, comprising a supporting sheet and an absorbent layer supported thereon; said absorbent layer comprising an absorbent material that contains at least a superabsorbent polymer material and optionally a cellulosic material; said absorbent structure and absorbent layer having a longitudinal dimension and average length, and transverse dimension and average width, and a height; said absorbent layer having a longitudinal axis and perpendicular thereto a transverse axis; and said absorbent layer having a first longitudinally extending side portion on one side of said longitudinal axis, and a second longitudinally extending side portion on the other side of said longitudinal axis; and said absorbent structure and said absorbent layer thereof having a front region, back region and therein between a crotch region, each arranged sequentially in said longitudinal dimension; whereby said absorbent layer has at least a first substantially longitudinally extending channel present in said first side portion, and a second substantially longitudinally extending channel present in said second side portion, said channels being substantially free of said superabsorbent polymer material and extending through said height of said absorbent layer; wherein the channels do not extend up to any of the longitudinal side edges, or a transverse front edge or back edge of said absorbent layer, the channels are present at least in the crotch region, and the first and second substantially longitudinally extending channels are curved and are mirror images of one another in the longitudinal axis, and whereby said absorbent structure comprises one or more adhesive materials (40; 60) to at least partially immobilize said absorbent layer onto said supporting sheet, whereby said one or more adhesive material includes a first adhesive material applied to said absorbent layer or part thereof, once said layer is present on said supporting sheet, and/or whereby said one or more adhesive materials includes a second adhesive material present between said supporting sheet and said absorbent layer.
A radiation detector, comprising: a plurality of detector units (12a, 12b) each comprising a plurality of photosensitive pixels and each comprising at least one scintillation device optically coupled to the plurality of photosensitive pixels; and a substrate foil forming a common substrate for carrying each of the detector units (12a, 12b), wherein the detector units (12a, 12b) are arranged in juxtaposition on the substrate foil; wherein at least two directly adjoining scintillation devices of at least two directly adjoining detector units (12a, 12b) are spaced apart from each other, such that the radiation detector is bendable along at least a part of a bending region of the substrate foil, wherein the bending region is arranged between said at least two directly adjoining scintillation devices; characterized in that each detector unit (12a, 12b) comprises a separate addressing circuit for addressing the respective detector unit (12a, 12b) and/or a separate signal read-out circuit for reading-out signals from the respective detector unit (12a, 12b); and a switch element is arranged between two detector units (12a, 12b); and wherein the switch element is configured for electronically interconnecting and/or decoupling the two detector units (12a, 12b) from each other. a plurality of detector units (12a, 12b) each comprising a plurality of photosensitive pixels and each comprising at least one scintillation device optically coupled to the plurality of photosensitive pixels; and a substrate foil forming a common substrate for carrying each of the detector units (12a, 12b), wherein the detector units (12a, 12b) are arranged in juxtaposition on the substrate foil; wherein at least two directly adjoining scintillation devices of at least two directly adjoining detector units (12a, 12b) are spaced apart from each other, such that the radiation detector is bendable along at least a part of a bending region of the substrate foil, wherein the bending region is arranged between said at least two directly adjoining scintillation devices; characterized in that each detector unit (12a, 12b) comprises a separate addressing circuit for addressing the respective detector unit (12a, 12b) and/or a separate signal read-out circuit for reading-out signals from the respective detector unit (12a, 12b); and a switch element is arranged between two detector units (12a, 12b); and wherein the switch element is configured for electronically interconnecting and/or decoupling the two detector units (12a, 12b) from each other.
Collar of a knitted garment, in particular a polo shirt, comprising: - a first flexible knit portion comprising a rectilinear-shaped inner longitudinal end and a substantially curved-shaped outer longitudinal end; - a second structured knitted stiff knit portion, distinct from said first portion and constituting the collar stand, said second portion comprising an inner longitudinal end of rectilinear shape corresponding to said inner longitudinal end of said first portion and an outer longitudinal end of substantially curved shape, said second portion being integral with said first portion at said inner longitudinal end; the collar being characterised by, - a substantially curved-shaped longitudinal fold axis of said first portion, said longitudinal fold axis being located in said first portion, parallel to said outer longitudinal end, so that said first portion folds along said longitudinal fold axis to cover a part of said first portion and the whole of said second portion; said collar comprising two rectilinear-shaped lateral ends; and said collar defining a height H1 between said outer longitudinal end and said outer longitudinal end at its central portion, and a height H2 at each of its two lateral ends, with H1 equal to or greater than H2. - a first flexible knit portion comprising a rectilinear-shaped inner longitudinal end and a substantially curved-shaped outer longitudinal end; - a second structured knitted stiff knit portion, distinct from said first portion and constituting the collar stand, said second portion comprising an inner longitudinal end of rectilinear shape corresponding to said inner longitudinal end of said first portion and an outer longitudinal end of substantially curved shape, said second portion being integral with said first portion at said inner longitudinal end; the collar being characterised by, - a substantially curved-shaped longitudinal fold axis of said first portion, said longitudinal fold axis being located in said first portion, parallel to said outer longitudinal end, so that said first portion folds along said longitudinal fold axis to cover a part of said first portion and the whole of said second portion; said collar comprising two rectilinear-shaped lateral ends; and said collar defining a height H1 between said outer longitudinal end and said outer longitudinal end at its central portion, and a height H2 at each of its two lateral ends, with H1 equal to or greater than H2.
Solid wheel for a rail vehicle, comprising a wheel rim which is arranged on the circumference of the solid wheel, which comprises a tread, which wheel rim is connected to a hub for a wheel set shaft via an end wall and a rear wall, said hub being arranged in the centre of the solid wheel and having a longitudinal axis, characterised in that the solid wheel forms a cavity which is delimited by the end wall and the rear wall, wherein the end wall and the rear wall transition into each other below the wheel rim in an arched manner and wherein the end wall has first openings and the rear wall has second openings in order to open the cavity outward in a spoked manner.
A suspension system for a silencing device pertaining to a vehicle, which system comprises - at least two fitting elements closely associated with the underside of the silencing device, - at least two sliderails which each have a first end and a second end and are intended to be closely associated with the underside of the silencing device, - at least two support rails which each have a first end and a second end and are intended to be firmly attached to the vehicle, - the sliderails being intended to be closely associated with, and be movable relative to, the support rails, thereby making it possible for the silencing device to be drawn out, characterised in that the silencing device is firmly attached to the sliderails via at least two damping units which are intended to be fitted in said fitting elements, and that each sliderail has at least two rollers which are situated at its first end and abut against the longitudinal sides of the support rail when the sliderail is movable relative to the support rail, and are accommodated in recesses in the support rail when the silencing device is fitted in the vehicle, i.e. when the sliderail is fully inserted in the support rail. - at least two fitting elements closely associated with the underside of the silencing device, - at least two sliderails which each have a first end and a second end and are intended to be closely associated with the underside of the silencing device, - at least two support rails which each have a first end and a second end and are intended to be firmly attached to the vehicle, - the sliderails being intended to be closely associated with, and be movable relative to, the support rails, thereby making it possible for the silencing device to be drawn out, characterised in that the silencing device is firmly attached to the sliderails via at least two damping units which are intended to be fitted in said fitting elements, and that each sliderail has at least two rollers which are situated at its first end and abut against the longitudinal sides of the support rail when the sliderail is movable relative to the support rail, and are accommodated in recesses in the support rail when the silencing device is fitted in the vehicle, i.e. when the sliderail is fully inserted in the support rail.
Isolated nucleic acid which has a sequence selected from the groups A1) to D1 and G1) A1) a sequence according to Seq ID No. 1, wherein this sequence codes for a protein which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, B1) an intron-free sequence which is derived from a sequence according to A1) and which encodes the same protein or peptide as the sequence according to Seq ID No. 1, C1) a sequence which encodes a protein or peptide which includes the amino acid sequence according to Seq ID No. 2 and which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, D1) a sequence which is at least 70% identical with a sequence according to one of the groups A1) to C1), wherein this sequence codes for a protein or peptide which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, G1) a complementary sequence to a sequence according to one of the groups A1) to D1). A1) a sequence according to Seq ID No. 1, wherein this sequence codes for a protein which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, B1) an intron-free sequence which is derived from a sequence according to A1) and which encodes the same protein or peptide as the sequence according to Seq ID No. 1, C1) a sequence which encodes a protein or peptide which includes the amino acid sequence according to Seq ID No. 2 and which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, D1) a sequence which is at least 70% identical with a sequence according to one of the groups A1) to C1), wherein this sequence codes for a protein or peptide which is capable of converting phytosphingosine to triacetylphytosphingosine by transfer of the acetyl residues from three molecules of acetyl coenzyme A, G1) a complementary sequence to a sequence according to one of the groups A1) to D1).
A machine for the treatment of liquid and semi-liquid food mixtures, comprising at least one container or tank for the mixture, at least one circuit for cooling and/or heating basic products of which the mixture consists, a mixer rotating inside the tank to mix the basic products contained in the tank; the cooling and/or heating circuit comprising a compressor driven by an electric motor and further comprising a condenser connected to the least one container or tank, an expansion valve, and an evaporator; the machine being characterised in that it comprises a unit designed to control the speed of rotation of the compressor electric motor, for regulating compressor operation and varying the thermal power supplied by the compressor at least according to the quantity of mixture treated loaded in the tank, said machine comprising a plurality of level sensors designed to detect the quantity of mixture treated and/or a plurality of temperature sensors designed to detect the temperature of the mixture treated and/or a module designed to identify the type of mixture treated present in the tank the control unit comprises an electronic board with a microprocessor designed to detect electric signals indicating at least the quantity of the mixture and/or the temperature of the mixture, allowing selection of the correct power with which the actuator device supplies the compressor electric motor and the machine further comprising temperature and pressure sensor placed along the cooling and/or heating circuit to constantly monitor the temperature and pressure value of the entire system and to send the temperature and pressure value to the electronic board.
A wearable neuromodulator device, the device comprising: a flexible substrate; a first electrode on the flexible substrate; a second electrode on the flexible substrate; a battery; a control circuitry; wherein the control circuity has a first mode of operation in which the battery is disengaged from the control circuity and a second mode of operation in which the battery is engaged with the control circuitry, further wherein the control circuitry is configured to deliver a pre-defined waveform between the first and second electrodes when the battery is engaged with the control circuitry and an impedance between the first and second electrodes is within a predefined range, wherein the waveform has a frequency of between 100 Hz and 15 KHz and delivers a charge per phase of between 0.1-10 microCoulombs; a cover covering the flexible substrate so that the battery and control circuitry are enclosed between the cover and the flexible substrate; wherein a thickness of the device between the cover and the flexible substrate is less than 5 mm; and a pull tab removably coupled with the control circuitry and configured to switch the control circuitry from the first mode to the second mode when the pull tab is pulled, wherein the device has a principle diameter that is between 2 cm and 10 cm. a flexible substrate; a first electrode on the flexible substrate; a second electrode on the flexible substrate; a battery; a control circuitry; wherein the control circuity has a first mode of operation in which the battery is disengaged from the control circuity and a second mode of operation in which the battery is engaged with the control circuitry, further wherein the control circuitry is configured to deliver a pre-defined waveform between the first and second electrodes when the battery is engaged with the control circuitry and an impedance between the first and second electrodes is within a predefined range, wherein the waveform has a frequency of between 100 Hz and 15 KHz and delivers a charge per phase of between 0.1-10 microCoulombs; a cover covering the flexible substrate so that the battery and control circuitry are enclosed between the cover and the flexible substrate; wherein a thickness of the device between the cover and the flexible substrate is less than 5 mm; and a pull tab removably coupled with the control circuitry and configured to switch the control circuitry from the first mode to the second mode when the pull tab is pulled, wherein the device has a principle diameter that is between 2 cm and 10 cm.