A topical aqueous-free UBIQUINOL supplement composition, containing ACPF mixtures, useful in reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces, including: a saliva soluble, aqueous-free emulsion carrier being comprised of polydimethylsiloxane emulsified in a nonionic surfactant that is capable of forming a mucoadhesive gel in the presence of saliva; an effective level of UBIQUINOL supplement; a stabilizing composition for UBIQUINOL supplement; spilanthes extract; a trans-oral mucosal absorption facilitator; and an ACPF (Amorphous Calcium Phosphate Fluoride) mixture, wherein: upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said UBIQUINOL supplement, stabilizer composition for UBIQUINOL supplement, trans-oral mucosal absorption facilitator, spilanthes extract and ACPF mixtures onto said oral mucosa; and upon contacting said oral mucosa, said UBIQUINOL supplement, spilanthes extract and trans-oral mucosal absorption facilitator passively diffuse through said oral mucosa, while said ACPF mixture remineralizes tooth surfaces: (a) reducing oxidative stress; (b) restoring and maintaining adequate "local" levels of UBIQUINOL; (c) relieving oral discomfort; (d) relieving dry mouth; and (e) remineralizing tooth surfaces. a saliva soluble, aqueous-free emulsion carrier being comprised of polydimethylsiloxane emulsified in a nonionic surfactant that is capable of forming a mucoadhesive gel in the presence of saliva; an effective level of UBIQUINOL supplement; a stabilizing composition for UBIQUINOL supplement; spilanthes extract; a trans-oral mucosal absorption facilitator; and an ACPF (Amorphous Calcium Phosphate Fluoride) mixture, wherein: upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said UBIQUINOL supplement, stabilizer composition for UBIQUINOL supplement, trans-oral mucosal absorption facilitator, spilanthes extract and ACPF mixtures onto said oral mucosa; and upon contacting said oral mucosa, said UBIQUINOL supplement, spilanthes extract and trans-oral mucosal absorption facilitator passively diffuse through said oral mucosa, while said ACPF mixture remineralizes tooth surfaces: (a) reducing oxidative stress; (b) restoring and maintaining adequate "local" levels of UBIQUINOL; (c) relieving oral discomfort; (d) relieving dry mouth; and (e) remineralizing tooth surfaces. upon application to the oral mucosa, said composition forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa; upon continuous exposure of said saliva soluble, mucoadhesive gel to saliva flow, said mucoadhesive gel gradually dissolves effecting controlled release of said UBIQUINOL supplement, stabilizer composition for UBIQUINOL supplement, trans-oral mucosal absorption facilitator, spilanthes extract and ACPF mixtures onto said oral mucosa; and upon contacting said oral mucosa, said UBIQUINOL supplement, spilanthes extract and trans-oral mucosal absorption facilitator passively diffuse through said oral mucosa, while said ACPF mixture remineralizes tooth surfaces: (a) reducing oxidative stress; (b) restoring and maintaining adequate "local" levels of UBIQUINOL; (c) relieving oral discomfort; (d) relieving dry mouth; and (e) remineralizing tooth surfaces. (a) reducing oxidative stress; (b) restoring and maintaining adequate "local" levels of UBIQUINOL; (c) relieving oral discomfort; (d) relieving dry mouth; and (e) remineralizing tooth surfaces.