mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula I or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is: or;each R 2 and R 3 is independently selected from optionally substituted aryl or optionally substituted heteroaryl; R 4 is a fully saturated heterocyclyl, -CH(R 5)N(R 5)-aryl, -CH(R 5)N(R 5)-heterocyclyl, -CH(R 5)N(R 5)-carbocyclyl, -CH 2 -heterocyclyl, 1H-indol-2-yl, indolin-2-yl, 1,2,3,4-tetrahydroquinolin-2-yl, imidazo[1,2- a]pyridine-5-yl, 5,6,7,8-tetrahydroimidazo[1,2- a]pyridine-5-yl, -(CR 5 R 6) 1-4 N(R 5)C O(C 1 -C 6 alkyl), or -(CR 5 R 6) 1-4 N(R 5)SO 2 (C 1 -C 6 alkyl), wherein each saturated heterocyclyl, heteroaryl, aryl, heterocyclyl, or carbocyclyl is independently optionally substituted; each R 5 is independently selected from hydrogen and methyl; and each R 6 is independently selected from hydrogen, methyl, CH 2 OH, CH(CH 3)OH, CH 2 NH 2, or CH(CH 3)NH 2; wherein: "heterocyclyl" refers to a monocyclic, bicyclic or tricyclic, ring structure that is not fully aromatic and includes one to four heteroatoms independently selected from N, O, or S in one or more of the rings; and "carbocyclyl" refers to a monocyclic, bicyclic or tricyclic, hydrocarbon ring system that is not fully aromatic, wherein any ring atom capable of substitution can be substituted by one or more substituents.;each R 2 and R 3 is independently selected from optionally substituted aryl or optionally substituted heteroaryl; R 4 is a fully saturated heterocyclyl, -CH(R 5)N(R 5)-aryl, -CH(R 5)N(R 5)-heterocyclyl, -CH(R 5)N(R 5)-carbocyclyl, -CH 2 -heterocyclyl, 1H-indol-2-yl, indolin-2-yl, 1,2,3,4-tetrahydroquinolin-2-yl, imidazo[1,2- a]pyridine-5-yl, 5,6,7,8-tetrahydroimidazo[1,2- a]pyridine-5-yl, -(CR 5 R 6) 1-4 N(R 5)C O(C 1 -C 6 alkyl), or -(CR 5 R 6) 1-4 N(R 5)SO 2 (C 1 -C 6 alkyl), wherein each saturated heterocyclyl, heteroaryl, aryl, heterocyclyl, or carbocyclyl is independently optionally substituted; each R 5 is independently selected from hydrogen and methyl; and each R 6 is independently selected from hydrogen, methyl, CH 2 OH, CH(CH 3)OH, CH 2 NH 2, or CH(CH 3)NH 2; wherein: "heterocyclyl" refers to a monocyclic, bicyclic or tricyclic, ring structure that is not fully aromatic and includes one to four heteroatoms independently selected from N, O, or S in one or more of the rings; and "carbocyclyl" refers to a monocyclic, bicyclic or tricyclic, hydrocarbon ring system that is not fully aromatic, wherein any ring atom capable of substitution can be substituted by one or more substituents. "heterocyclyl" refers to a monocyclic, bicyclic or tricyclic, ring structure that is not fully aromatic and includes one to four heteroatoms independently selected from N, O, or S in one or more of the rings; and "carbocyclyl" refers to a monocyclic, bicyclic or tricyclic, hydrocarbon ring system that is not fully aromatic, wherein any ring atom capable of substitution can be substituted by one or more substituents.
A method of manufacturing a patch preparation comprising: pouring a composition for forming an adhesive layer into a container having a concave part with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer and an organic solvent, wherein the depth of the concave part is not less than 110% of the thickness of the drug-containing adhesive layer of the patch preparation to be manufactured, and the difference between the depth of the concave part and thickness of the drug-containing adhesive layer (depth of concave part minus thickness of drug-containing adhesive layer) is not more than 20mm; removing the organic solvent from the composition through drying to form the drug-containing adhesive layer in the concave part; and laminating a support on the drug-containing adhesive layer to give the patch preparation comprising the support and the drug-containing adhesive layer formed on one surface of the support. pouring a composition for forming an adhesive layer into a container having a concave part with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer and an organic solvent, wherein the depth of the concave part is not less than 110% of the thickness of the drug-containing adhesive layer of the patch preparation to be manufactured, and the difference between the depth of the concave part and thickness of the drug-containing adhesive layer (depth of concave part minus thickness of drug-containing adhesive layer) is not more than 20mm; removing the organic solvent from the composition through drying to form the drug-containing adhesive layer in the concave part; and laminating a support on the drug-containing adhesive layer to give the patch preparation comprising the support and the drug-containing adhesive layer formed on one surface of the support.
A reference signal allocation method comprising: allocating first reference signals to all resource blocks in one frame, the first reference signals being cell-specific and being used in LTE terminals supporting a radio communication base station apparatus having N antennas and also used in LTE-advanced terminals supporting a radio communication base station apparatus having more antennas than the N antennas, a resource block being composed of a number of subcarriers in a frequency domain and a number of OFDM symbols in one of subframes in a time domain, and the one frame being divided into the subframes; allocating second reference signals to part of the resource blocks in the one frame, the second reference signals being cell-specific and being used only in the LTE-advanced terminals; and allocating data signals directed to the LTE terminals only to resource blocks, to which the second reference signals are not allocated. allocating first reference signals to all resource blocks in one frame, the first reference signals being cell-specific and being used in LTE terminals supporting a radio communication base station apparatus having N antennas and also used in LTE-advanced terminals supporting a radio communication base station apparatus having more antennas than the N antennas, a resource block being composed of a number of subcarriers in a frequency domain and a number of OFDM symbols in one of subframes in a time domain, and the one frame being divided into the subframes; allocating second reference signals to part of the resource blocks in the one frame, the second reference signals being cell-specific and being used only in the LTE-advanced terminals; and allocating data signals directed to the LTE terminals only to resource blocks, to which the second reference signals are not allocated.
Tracheal ventilation device having a cannula, having a filling tube and an inflatable cuff disposed around the cannula, the cuff being in fluid contact with the filling tube, characterized in that the internal surface of the filling tube is formed by a solid hydrophilic layer.
A shaped product comprising: a fiber-reinforced composite material including reinforcing fibers with an average length of 5 mm or more and 100 mm or less and a thermoplastic resin, wherein the reinforcing fibers are at least one selected from the group consisting of carbon fibers, glass fibers, and aramid fibers, a volume fraction of the reinforcing fibers (Vf = 100 × volume of the reinforcing fibers/(volume of the reinforcing fibers + volume of the thermoplastic resin)) is 5 to 80%, grains, which are patterns formed on the surface of the shaped product, are formed on a surface of the shaped product, and a ratio of a reinforcing fiber bundle including the reinforcing fibers of a critical number of single fiber or more, the critical number being defined by Formula, to a total amount of the reinforcing fibers is 20 Vol% or more and 99 Vol% or less: Critical number of single fiber = 600 / D wherein D is an average fiber diameter (μm) of single reinforcing fiber. a fiber-reinforced composite material including reinforcing fibers with an average length of 5 mm or more and 100 mm or less and a thermoplastic resin, wherein the reinforcing fibers are at least one selected from the group consisting of carbon fibers, glass fibers, and aramid fibers, a volume fraction of the reinforcing fibers (Vf = 100 × volume of the reinforcing fibers/(volume of the reinforcing fibers + volume of the thermoplastic resin)) is 5 to 80%, grains, which are patterns formed on the surface of the shaped product, are formed on a surface of the shaped product, and a ratio of a reinforcing fiber bundle including the reinforcing fibers of a critical number of single fiber or more, the critical number being defined by Formula, to a total amount of the reinforcing fibers is 20 Vol% or more and 99 Vol% or less: Critical number of single fiber = 600 / D wherein D is an average fiber diameter (μm) of single reinforcing fiber.
Laser scanning microscope having - focusing means having a focal plane and comprising at least one optical element for focusing a laser beam, - drive means for displacing the at least one optical element of the focusing means for changing the position of the focal plane, and - deflecting means for deflecting the laser beam, characterised by a control system allowing for scanning at a frequency in the range of 50-200 Hz, the control system being configured to carry out the steps of - providing a periodical drive signal for the drive means having a frequency at which the shape of a resulting displacement response function (z(t)) of the drive means deviates from the shape of the drive signal, - obtaining time dependant displacement data of the at least one optical element of the focusing means in response to the periodical drive signal of the drive means, - calculating a response function (z(t)) from the time dependant displacement data, - waiting for sufficient periods of the periodical drive signal for the response function (z(t)) to become stable, - using the stable response function (z(t)) for calculating an XY drive signal for the deflecting means which takes into account the shape distortion of the stable response function (z(t)) with respect to the periodical drive signal, - generating the original drive signal for the drive means of the optical element and generating the corresponding XY drive signal for the deflecting means in order to move the focal volume of the laser beam along a given 3D trajectory within a sample to be examined. - focusing means having a focal plane and comprising at least one optical element for focusing a laser beam, - drive means for displacing the at least one optical element of the focusing means for changing the position of the focal plane, and - deflecting means for deflecting the laser beam, - providing a periodical drive signal for the drive means having a frequency at which the shape of a resulting displacement response function (z(t)) of the drive means deviates from the shape of the drive signal, - obtaining time dependant displacement data of the at least one optical element of the focusing means in response to the periodical drive signal of the drive means, - calculating a response function (z(t)) from the time dependant displacement data, - waiting for sufficient periods of the periodical drive signal for the response function (z(t)) to become stable, - using the stable response function (z(t)) for calculating an XY drive signal for the deflecting means which takes into account the shape distortion of the stable response function (z(t)) with respect to the periodical drive signal, - generating the original drive signal for the drive means of the optical element and generating the corresponding XY drive signal for the deflecting means in order to move the focal volume of the laser beam along a given 3D trajectory within a sample to be examined.
An apparatus comprising: a light source configured to output unpixelated light; an array of reflective pixel control elements configured to selectively reflect incident unpixelated light to produce first pixelated light defining first display content; a pixelated display configured to produce second pixelated light defining second display content; and an optical arrangement configured to direct unpixelated light from the light source to the array of reflective pixel control elements and to combine the pixelated light defining the first display content and the second pixelated light defining the second display content to provide, as an output, third pixelated light defining third display content. a light source configured to output unpixelated light; an array of reflective pixel control elements configured to selectively reflect incident unpixelated light to produce first pixelated light defining first display content; a pixelated display configured to produce second pixelated light defining second display content; and an optical arrangement configured to direct unpixelated light from the light source to the array of reflective pixel control elements and to combine the pixelated light defining the first display content and the second pixelated light defining the second display content to provide, as an output, third pixelated light defining third display content.
A coating system comprising (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents and a polymer comprising hydrophilic and hydrophobic portions; and (b) an elution-controlling topcoat layer that comprises 99% wt or greater of a poly(ethylene-co-vinyl acetate) copolymer wherein the vinyl acetate is present in an amount in the range of 10 % to 25% in the copolymer.
A fitting for a building door, with a carrier, and an antenna, characterized in that the antenna is disposed within the carrier, and the carrier in the area of the antenna is configured to be open to a front side of the carrier and to a rear side of the carrier, wherein the fitting includes a faceplate element, which covers the front side of the carrier at least in the area of the antenna, and a covering element, which covers the rear side of the carrier at least in the area of the antenna.
A rotatable apparatus comprising: a casing (30, 130) including a first casing face (31, 131) provided with an opening (33, 133) and a second casing face (32, 132) abutting the first casing face (31, 131), the second casing face (32, 132) intersecting the first casing face (31, 131) at angle θ1; and a protector (50, 150) for closing the opening (33, 133), the protector (50, 150) including a first protector face (51, 151) and a second protector face (52, 152) abutting the first protector face (51, 151), the second protector face (52, 152) intersecting the first protector face (51, 151) at angle θ2, wherein the protector (50, 150) is configured to be fixed to only the second casing face (32, 132), the angle θ2 is larger than the angle θ1 when the protector (50, 150) is removed from the casing (30, 130), and the protector (50, 150) is configured to be attached to the casing (30, 130) in such a manner that the second protector face (52, 152) is fixed to the second casing face (32, 132), and that the first protector face (51, 151) is elastically deformed so that an edge part of the first protector face (51, 151), which is located on the side opposite to the second protector face (52, 152), closely contacts the first casing face (31, 131). a casing (30, 130) including a first casing face (31, 131) provided with an opening (33, 133) and a second casing face (32, 132) abutting the first casing face (31, 131), the second casing face (32, 132) intersecting the first casing face (31, 131) at angle θ1; and a protector (50, 150) for closing the opening (33, 133), the protector (50, 150) including a first protector face (51, 151) and a second protector face (52, 152) abutting the first protector face (51, 151), the second protector face (52, 152) intersecting the first protector face (51, 151) at angle θ2, wherein the protector (50, 150) is configured to be fixed to only the second casing face (32, 132), the angle θ2 is larger than the angle θ1 when the protector (50, 150) is removed from the casing (30, 130), and the protector (50, 150) is configured to be attached to the casing (30, 130) in such a manner that the second protector face (52, 152) is fixed to the second casing face (32, 132), and that the first protector face (51, 151) is elastically deformed so that an edge part of the first protector face (51, 151), which is located on the side opposite to the second protector face (52, 152), closely contacts the first casing face (31, 131).
A noise reducing system comprising: a first microphone that picks up noise signal at a first location and that is electrically coupled to a first microphone output path; a loudspeaker that is electrically coupled to a loudspeaker input path and that radiates noise reducing sound at a second location; a second microphone that picks up residual noise from the noise and the noise reducing sound at a third location and that is electrically coupled to a second microphone output path; a first active noise reducing filter that is connected between the first microphone output path and the loudspeaker input path; and a second active noise reducing filter that is connected between the second microphone output path and the loudspeaker input path; in which the first active noise reduction filter is a shelving or equalization filter or comprises at least one shelving or equalization filter or both. a first microphone that picks up noise signal at a first location and that is electrically coupled to a first microphone output path; a loudspeaker that is electrically coupled to a loudspeaker input path and that radiates noise reducing sound at a second location; a second microphone that picks up residual noise from the noise and the noise reducing sound at a third location and that is electrically coupled to a second microphone output path; a first active noise reducing filter that is connected between the first microphone output path and the loudspeaker input path; and a second active noise reducing filter that is connected between the second microphone output path and the loudspeaker input path; in which the first active noise reduction filter is a shelving or equalization filter or comprises at least one shelving or equalization filter or both.
Light module (16; 160) for a motor vehicle headlamp, comprising a printed circuit board which has a front side and a rear side and which has a DMD chip on its front side, the chip having a front side carrying a micromirror and a rear side opposite its front side, and comprising a central support element which has a front side and a rear side, the light module having a cooling element assembly and the central support element having a central support element window, and the printed circuit board being arranged with its front side facing the rear side of the central support element such that the front side of the DMD chip covers an opening of the support element window, the micromirrors being arranged so as to be visible through the opening of the support element window, and the printed circuit board having a printed circuit board window, the opening of which is completely or partially covered by the rear side of the DMD chip, and the cooling element assembly having a cooling plunger which is supported on the rear side of the DMD chip through the printed circuit board window, and the cooling element assembly being otherwise arranged facing the rear side of the printed circuit board, and the light module (16;160) having an elastically deformed resilient connecting element, characterized in that the resilient connecting element is a leaf spring and the leaf spring has at least one end on the cooling element assembly side and at least one end on the support element side, and is rigidly connected, at its end on the cooling element assembly side, to an end of the cooling element assembly arranged on the rear side of the printed circuit board and is rigidly connected, at its end on the support element side, to the support element, and the printed circuit board being rigidly connected to the support element, the leaf spring being connected, at its end on the cooling element assembly side, in a frictional and/or interlocking manner to a remaining part of the cooling element assembly arranged on the rear side of the printed circuit board, the central support element having screw bosses which protrude from the rear side of the central support element and which have, on their ends facing away from the rear side, receptacles for the ends on the support element side of the leaf spring, the connection being made by interlocking elements of the remaining part of the cooling element assembly, which prevent the end on the cooling element assembly side of the leaf spring from moving toward the printed circuit board.
A method for controlling mode switching of a hybrid electric vehicle, comprising: acquiring a current drive state information of the hybrid electric vehicle; characterized in that performing, if the drive state information indicates that a current drive mode of the hybrid electric vehicle is a forward mode of a non-hybrid drive and in a case that a current speed reaches a speed limit, a pre-gear operation when a transmission gear of the hybrid electric vehicle is a neutral gear, to switch the transmission gear from the neutral gear to a second gear; and switching, if the drive state information meets preset switching conditions of drive modes, the hybrid electric vehicle from the non-hybrid drive mode to a hybrid drive mode when the transmission gear of the hybrid electric vehicle is the second gear, wherein performing, if the drive state information indicates that the current drive mode of the hybrid electric vehicle is the hybrid drive mode and a current speed of the hybrid electric vehicle is less than the speed limit, a reverse gear operation when the transmission gear of the hybrid electric vehicle is the second gear, to switch the transmission gear from the second gear to the neutral gear. acquiring a current drive state information of the hybrid electric vehicle; characterized in that performing, if the drive state information indicates that a current drive mode of the hybrid electric vehicle is a forward mode of a non-hybrid drive and in a case that a current speed reaches a speed limit, a pre-gear operation when a transmission gear of the hybrid electric vehicle is a neutral gear, to switch the transmission gear from the neutral gear to a second gear; and switching, if the drive state information meets preset switching conditions of drive modes, the hybrid electric vehicle from the non-hybrid drive mode to a hybrid drive mode when the transmission gear of the hybrid electric vehicle is the second gear, wherein performing, if the drive state information indicates that the current drive mode of the hybrid electric vehicle is the hybrid drive mode and a current speed of the hybrid electric vehicle is less than the speed limit, a reverse gear operation when the transmission gear of the hybrid electric vehicle is the second gear, to switch the transmission gear from the second gear to the neutral gear.