mhurhangee/ep-ind-claims huggingface dataset:
Chitosan-coated nanoliposomes or chitosan-coated lipid nanostructures for the administration of active molecules for use as pharmaceutical, nutraceutical or cosmetic agents, obtainable from a process comprising the following operations: a) providing, as a starting material, a suspension of nanoliposomes encapsulating one or more active ingredients to be administered, said nanoliposomes being made of phospholipids and cholesterol, preferably phosphatidylcholine and cholesterol, at a total lipid concentration of from 0.1 to 10 mg/mL; b) producing an aqueous solution containing chitosan at a chitosan concentration of from 0.005% to 0.015% w/v; c) pumping said nanoliposomes suspension and said aqueous solution containing chitosan through two volumetric pumps in a volume flow rate ratio of from 0.8:1 to 1,2:1; d) contacting the flows consisting of said nanoliposomes suspension and said aqueous solution containing chitosan by making them pass through a simil-microfluidic device, which effects an inter-diffusion of said nanoliposomes suspension into the stream of said aqueous solution by passage through a duct, for instance a hollow needle, of internal diameter below 1 mm, the duct of said aqueous solution having an internal diameter of 2-5 mm and a length after the injection point of 150-200 mm, thereby obtaining chitosan-coated nanostructures; e) collecting the nanostructures obtained in the previous production step. a) providing, as a starting material, a suspension of nanoliposomes encapsulating one or more active ingredients to be administered, said nanoliposomes being made of phospholipids and cholesterol, preferably phosphatidylcholine and cholesterol, at a total lipid concentration of from 0.1 to 10 mg/mL; b) producing an aqueous solution containing chitosan at a chitosan concentration of from 0.005% to 0.015% w/v; c) pumping said nanoliposomes suspension and said aqueous solution containing chitosan through two volumetric pumps in a volume flow rate ratio of from 0.8:1 to 1,2:1; d) contacting the flows consisting of said nanoliposomes suspension and said aqueous solution containing chitosan by making them pass through a simil-microfluidic device, which effects an inter-diffusion of said nanoliposomes suspension into the stream of said aqueous solution by passage through a duct, for instance a hollow needle, of internal diameter below 1 mm, the duct of said aqueous solution having an internal diameter of 2-5 mm and a length after the injection point of 150-200 mm, thereby obtaining chitosan-coated nanostructures; e) collecting the nanostructures obtained in the previous production step.
A S1R agonist compound for use in the treatment of progressive fibrosis in a tissue of a subject by reversing or inhibiting fibrotic remodeling of the extracellular matrix.
A method for alarming abnormality in tire air-pressure informing decrease in tire air-pressure mounted on a vehicle, characterized by comprising a step of judging (S 11-S 13) whether loads applied on respective tires are changed by the influence of air suspensions based on the difference of the heights of strokes between left wheel and right wheel in the vehicle equipped with the air suspensions and affect the rotational wheel speeds of tires or not, and not carrying out (S 14) the judgment of decrease in tire air-pressure when the air suspensions provide influence.
Implantable device for use in the human and/or animal body for closure or partial closure of defect openings, cavities, organ passages, etc. comprising carrier structure that is reproducible convertible from a primary form into a memorized secondary form, wherein the carrier structure has a proximal and a distal portion (10, 11) and is formed in the manner of a weft and/or mesh and/or layered cloth and/or gauze and wherein one portion has a form that opens towards the outside and the other portion has a form that is bulgy and closed, particularly closed by a sheath element, characterized in that the at least one portion comprises two sub-parts, of whom one unfolds first from the primary form into the secondary form and folds away from the other portion onto the second sub-part directed to that other portion, wherein the at least one double-layered portion is disc-shaped and the other portion is projecting balloon-like and/or anchor-like, wherein the balloon-like or anchor-like projecting portion has a sub-part folded inwardly into the implantable device.
A sole structure for an article of footwear comprising: a midsole system having: a bladder comprising four stacked polymeric sheets (432, 434, 436, 437) bonded to one another and defining a first cushioning layer, a second cushioning layer, and a third cushioning layer, each cushioning layer comprising a sealed chamber (438, 440, 441) retaining gas in isolation from each other sealed chamber (438, 440, 441); a sole layer overlying the bladder and configured with a bottom surface having an outer peripheral portion and a central portion surrounded by the outer peripheral portion; wherein the outer peripheral portion is mated with an upper surface of bladder in an unloaded state of the sole structure, and the central portion is at least partially spaced apart from the upper surface of the bladder in the unloaded state of the sole structure; wherein the outer peripheral portion of the sole layer extends around a front, a rear, a medial side, and a lateral side of the sole layer; wherein the outer peripheral portion of the sole layer completely surrounds the central portion of the sole layer; and wherein the central portion is recessed in the bottom surface of the sole layer further than the outer peripheral portion such that a ridge defines a boundary between the central portion and the outer peripheral portion. a bladder comprising four stacked polymeric sheets (432, 434, 436, 437) bonded to one another and defining a first cushioning layer, a second cushioning layer, and a third cushioning layer, each cushioning layer comprising a sealed chamber (438, 440, 441) retaining gas in isolation from each other sealed chamber (438, 440, 441); a sole layer overlying the bladder and configured with a bottom surface having an outer peripheral portion and a central portion surrounded by the outer peripheral portion; wherein the outer peripheral portion is mated with an upper surface of bladder in an unloaded state of the sole structure, and the central portion is at least partially spaced apart from the upper surface of the bladder in the unloaded state of the sole structure; wherein the outer peripheral portion of the sole layer extends around a front, a rear, a medial side, and a lateral side of the sole layer; wherein the outer peripheral portion of the sole layer completely surrounds the central portion of the sole layer; and wherein the central portion is recessed in the bottom surface of the sole layer further than the outer peripheral portion such that a ridge defines a boundary between the central portion and the outer peripheral portion.
Tool device comprising a first module and a second module which is removable from the first module, wherein the first and the second module are able to be plugged into one another along a plug-in axis that defines a plug-in direction; wherein the first module has a contact pressure blocking element, which is moved conjointly with the second module, and a contact pressure blockage element, wherein the contact pressure blocking element is rotatable relative to the contact pressure blockage element, between a normal position and a disassembly position, about the plug-in axis, wherein the second module in the normal position is held on the first module and in the disassembly position is removable from the first module; wherein the contact pressure blockage element permits a transfer of the contact pressure blocking element along the plug-in axis, towards the remainder of the first module, to a contact pressure position when the contact pressure blocking element is situated in the normal position, whereas the contact pressure blockage element blocks a transfer of the plug receptacle to the contact pressure position when the contact pressure blocking element is situated in the disassembly position, characterized in that the first module has a latching mechanism which effects latching of the contact pressure blocking element in the disassembly position when the second module is being removed from the first module.
A linen sour treatment/prespot composition with iron control comprising a hydroxycarboxylic acid, an acid source, and one or more polymers or copolymers of acrylic acid or maleic acid, wherein said acid source is a combination of sulfuric acid and urea to form urea sulfate.
A machine for making and dispensing semiliquid and/or semisolid food products comprising a working unit equipped with a cylinder for processing a mixture of a basic product and air, a heat exchange fluid flow chamber located around the cylinder, a dispensing tap and means for treating and feeding the heat exchange fluid to the flow chamber; a flexible container for containing the basic product; a duct for supplying the mixture of basic product and air to the processing cylinder, a peristaltic pump connected to the supply duct and designed to transfer the basic product from the container to the processing cylinder, at least one first pressure sensor located along the supply duct downstream of the peristaltic pump and designed to send to a control and drive unit a signal indicating the pressure at which the mixture is fed into the processing cylinder; the unit sending as output at least one signal for adjusting the peristaltic pump, characterized in that it comprises means for generating a flow of air under pressure connected to the infeed end of the peristaltic pump.
A sample encapsulation system comprising: - a base; - a chamber, the chamber having an inlet; - a chamber housing, wherein the chamber housing is movably mounted to the fixture and the base, and wherein the chamber and housing are affixed relative to one another; - a cap; - a first ram operably mounted to the cap for engaging the chamber inlet; - a second ram positioned in the chamber opposite the inlet, the second ram movable toward and away from the first ram; - a heating assembly; and - a cooling assembly, the cooling assembly including a manifold, wherein the chamber, chamber housing and base are movable toward the cap for engaging the first ram with the chamber inlet during an encapsulation cycle and away from the cap, disengaging the first ram from the chamber inlet following an encapsulation cycle, characterized in that the chamber housing has an inner housing and an outer housing, the chamber being fixedly mounted at least in part within the inner housing, the heating assembly is positioned at least in part in the inner housing; the cooling assembly includes a cooling jacket defined in part by the inner housing and the outer housing, wherein the manifold is mounted to the outer housing and wherein the manifold includes two openings in fluid communication with the cooling jacket, one of the openings being a coolant drainage opening, the other opening being a vacuum relief opening, wherein a vacuum relief check valve is mounted to the vacuum relief opening. - a base; - a chamber, the chamber having an inlet; - a chamber housing, wherein the chamber housing is movably mounted to the fixture and the base, and wherein the chamber and housing are affixed relative to one another; - a cap; - a first ram operably mounted to the cap for engaging the chamber inlet; - a second ram positioned in the chamber opposite the inlet, the second ram movable toward and away from the first ram; - a heating assembly; and - a cooling assembly, the cooling assembly including a manifold, wherein the chamber, chamber housing and base are movable toward the cap for engaging the first ram with the chamber inlet during an encapsulation cycle and away from the cap, disengaging the first ram from the chamber inlet following an encapsulation cycle, the chamber housing has an inner housing and an outer housing, the chamber being fixedly mounted at least in part within the inner housing, the heating assembly is positioned at least in part in the inner housing; the cooling assembly includes a cooling jacket defined in part by the inner housing and the outer housing, wherein the manifold is mounted to the outer housing and wherein the manifold includes two openings in fluid communication with the cooling jacket, one of the openings being a coolant drainage opening, the other opening being a vacuum relief opening, wherein a vacuum relief check valve is mounted to the vacuum relief opening.
A method for congestion monitoring in a data network, the method comprising: determining, at a server in the data network, that a user device has initiated a data session with the data network; monitoring, at the server, a plurality of data flows (202, 204, 212, 214, 222, 224, 232, 234) associated with the data session to determine an average bandwidth of the plurality of data flows (202, 204, 212, 214, 222, 224, 232, 234); and determining a first congestion status of the data session based on the average bandwidth and one or more first criteria; whereby: the one or more first criteria comprise a first threshold level and a first time period; and the determining the first congestion status comprises: determining the data session as a congested data session candidate when the average bandwidth is below the first threshold; and determining the first congestion status as indicating that the data session is congested when the average bandwidth of the congested data session candidate remains below the first threshold level for longer than the first time period. determining, at a server in the data network, that a user device has initiated a data session with the data network; monitoring, at the server, a plurality of data flows (202, 204, 212, 214, 222, 224, 232, 234) associated with the data session to determine an average bandwidth of the plurality of data flows (202, 204, 212, 214, 222, 224, 232, 234); and determining a first congestion status of the data session based on the average bandwidth and one or more first criteria; whereby: the one or more first criteria comprise a first threshold level and a first time period; and the determining the first congestion status comprises: determining the data session as a congested data session candidate when the average bandwidth is below the first threshold; and determining the first congestion status as indicating that the data session is congested when the average bandwidth of the congested data session candidate remains below the first threshold level for longer than the first time period. the one or more first criteria comprise a first threshold level and a first time period; and the determining the first congestion status comprises: determining the data session as a congested data session candidate when the average bandwidth is below the first threshold; and determining the first congestion status as indicating that the data session is congested when the average bandwidth of the congested data session candidate remains below the first threshold level for longer than the first time period. determining the data session as a congested data session candidate when the average bandwidth is below the first threshold; and determining the first congestion status as indicating that the data session is congested when the average bandwidth of the congested data session candidate remains below the first threshold level for longer than the first time period.
Multi conductor cable having a flat shape for connecting a portable electric power tool to a power supply and operation control unit, comprising a connector plug attached to one end of the cable for connecting the cable to the power tool, and a twisted section close to the connector plug for facilitating universal bending of the cable, characterized in that adjacent its connector plug end the cable is provided with an external flexible transition sleeve, said transition sleeve extends over at least a part of the twisted section, said transition sleeve comprises a cylindrical section at the connector plug end of the cable and two parallel tongues (20,21) which taper along the cable over at least a part of the twisted section, said tongues providing a successively increasing strengthening effect towards bending of the cable the closer they get to the connector plug.
A wideband sonar transmitter, comprising: a power supply (160, 155, 140); a pair of switches (125, 135); and a wideband transformer having a secondary coil for driving a transducer and a primary coil having a center tap driven by the power supply (160, 155, 140), wherein a first end of the primary coil couples to ground through a first one of the switches, and a second end of the primary coil couples to ground through a second one of the switches, characterised by: the secondary coil including a plurality of windings (1105, 1120, 1125, 1130) arranged into a first section, a middle section, and a final section; and a primary coil winding (1110, 1115) wound only with the secondary coil windings forming the middle section. a power supply (160, 155, 140); a pair of switches (125, 135); and a wideband transformer having a secondary coil for driving a transducer and a primary coil having a center tap driven by the power supply (160, 155, 140), wherein a first end of the primary coil couples to ground through a first one of the switches, and a second end of the primary coil couples to ground through a second one of the switches, characterised by: the secondary coil including a plurality of windings (1105, 1120, 1125, 1130) arranged into a first section, a middle section, and a final section; and a primary coil winding (1110, 1115) wound only with the secondary coil windings forming the middle section. the secondary coil including a plurality of windings (1105, 1120, 1125, 1130) arranged into a first section, a middle section, and a final section; and a primary coil winding (1110, 1115) wound only with the secondary coil windings forming the middle section.
A PK fertilizer comprising, as constituents, conditioned sewage sludge and papermaking sludge, the fertilizer being in the form of dried granules having a moisture content of 5 to 10 percent by mass, the mass fraction of the papermaking sludge in the PK fertilizer being higher than the fraction of sewage sludge in the PK fertilizer and the fraction of papermaking sludge in the PK fertilizer being 50 to 60 percent by mass and having a moisture content of 5 to 10 percent by mass.
A mounting assembly for a hair cutting appliance, the mounting assembly comprising: a head configured to receive a cutting unit; a base, wherein the head is mounted to the base via a pair of arms to form a linkage, each arm being coupled at a joint to a head coupling on the head, and coupled at a joint to a respective base coupling on the base, the base couplings spaced apart along a movement line, and each joint configured to permit pivoting movement about parallel pivot axes; a stroke limiter configured to obstruct pivoting movement of the head relative to the base beyond a limit; characterised in that at least one of the base couplings is a flexible base coupling which is elastically mounted to a body of the base such that the respective flexible base coupling is moveable relative to the body in a direction having a component which is parallel to the movement line and away from the other base coupling, to permit pivoting movement of the head relative to the base beyond the limit imposed by the stroke limiter. a head configured to receive a cutting unit; a base, wherein the head is mounted to the base via a pair of arms to form a linkage, each arm being coupled at a joint to a head coupling on the head, and coupled at a joint to a respective base coupling on the base, the base couplings spaced apart along a movement line, and each joint configured to permit pivoting movement about parallel pivot axes; a stroke limiter configured to obstruct pivoting movement of the head relative to the base beyond a limit; characterised in that at least one of the base couplings is a flexible base coupling which is elastically mounted to a body of the base such that the respective flexible base coupling is moveable relative to the body in a direction having a component which is parallel to the movement line and away from the other base coupling, to permit pivoting movement of the head relative to the base beyond the limit imposed by the stroke limiter.
Semiconductor optical amplifier possessing an active zone, said active zone having an initial gain curve dependent on the wavelength and possessing a first bandwidth, characterized in that said amplifier includes, in the vicinity of said active zone, an electrically tuneable photonic-crystal waveguide, said waveguide being dimensioned and tunable so that the final gain curve of the optical amplifier has a second bandwidth greater than the first bandwidth.
A pack comprising powder or granules of a polymeric material having a melt viscosity in the range 0.05 to less than 0.11 kNsm -2, when measured using capillary rheometry operating at 400°C at a shear rate of 1000s -1 using a tungsten carbide die, 0.5 x 3.175mm, wherein said polymeric material is of a type which includes: (a) phenyl moieties; (b) carbonyl moieties; and (c) ether moieties; wherein said polymeric material is selected from the group comprising polyetheretherketone, polyetherketone, polyetherketoneketone, polyetherketoneetherketoneketone, polyetheretherketoneketone, polyether-diphenyl-ether-phenyl-ketone-phenyl. (a) phenyl moieties; (b) carbonyl moieties; and (c) ether moieties;
Stent with a tubular support frame made of axially sequential ring segments (3, 4, 5) which are formed by segmented braces (6, 7) interconnected continuously via transfer sections (8, 9) and adjacent ring segments (3, 4, 5) are coupled by connecting braces, characterised in that the segmented braces (6, 7) are curved in a wavelike manner and that each front end transfer section has an axially projecting widened head end (22, 23) on at least one back end ring segment viewed in the longitudinal axis of the stent wherein adjacent head ends (22, 23) are arranged offset in the circumferential direction in the longitudinal axis of the stent and are connected to the adjacent ring segment via connecting braces, wherein each connecting brace has an axial section curved in a wavelike manner and a compensation segment configured in a V-shape pointing in the circumferential direction of the support frame.