A pipetting assistance system (1; 50; 100; 100'; 200; 300; 400) for assisting manual pipetting or dispensing of a plurality of samples in an operating position of a sample receiving assembly (20; 120; 120'; 120"; 220) by a user-guided pipetting or dispensing device, said pipetting assistance system comprising: a base device (10; 110; 110'; 210) comprising positioning means (12a, 12b; 112a, 112b; 212a, 212b) arranged for positioning the sample receiving assembly in the processing position within a positioning space (11; 111, 211) of the base device which is open at least along a plane for pipetting, the sample receiving assembly (20; 120; 120'; 120"; 220) comprising a plurality of sample receptacles (21; 121; 121'; 121"; 221), a measuring assembly (28; 48; 119; 119'; 228) with a plurality of measuring elements (22, 23; 22'; 23'; 22"; 23"; 116; 117; 116'; 117'; 116"; 117"; 116′′′; 117′′′; 222, 223; 42) which are arranged below this plane at least in the processing position and by means of which the occupancy state of at least one sample receptacle can be detected in the processing position, an output device (18; 38; 118; 229) for outputting information about the occupancy state of at least one sample receptacle to the user, and an electronic control device (13; 33; 113; 213) which is set up to determine the occupancy state of at least one sample receptacle (21; 121; 121'; 121"; 221) in the processing position by controlling the measuring assembly (28; 48; 119; 119'; 228), and to output the information about the occupancy state of the at least one sample receptacle to the user by controlling the output device (18; 38; 118; 229) depending on the occupancy state of the latter, characterized in that the measuring assembly (28; 48; 119; 119'; 228) is arranged in the processing position partially or completely in the positioning space (11; 111, 211) and the plurality of measuring elements (22, 23; 22'; 23'; 22"; 23"; 116; 117; 116'; 117'; 116"; 117"; 116′′′; 117′′′; 222, 223; 42) is an integral part of the sample receptacle assembly (20; 120; 120'; 120"; 220) and the dispensing means (18; 38; 118; 229) is an integral part of the base device (10; 110; 110'; 210). a base device (10; 110; 110'; 210) comprising positioning means (12a, 12b; 112a, 112b; 212a, 212b) arranged for positioning the sample receiving assembly in the processing position within a positioning space (11; 111, 211) of the base device which is open at least along a plane for pipetting, the sample receiving assembly (20; 120; 120'; 120"; 220) comprising a plurality of sample receptacles (21; 121; 121'; 121"; 221), a measuring assembly (28; 48; 119; 119'; 228) with a plurality of measuring elements (22, 23; 22'; 23'; 22"; 23"; 116; 117; 116'; 117'; 116"; 117"; 116′′′; 117′′′; 222, 223; 42) which are arranged below this plane at least in the processing position and by means of which the occupancy state of at least one sample receptacle can be detected in the processing position, an output device (18; 38; 118; 229) for outputting information about the occupancy state of at least one sample receptacle to the user, and an electronic control device (13; 33; 113; 213) which is set up to determine the occupancy state of at least one sample receptacle (21; 121; 121'; 121"; 221) in the processing position by controlling the measuring assembly (28; 48; 119; 119'; 228), and to output the information about the occupancy state of the at least one sample receptacle to the user by controlling the output device (18; 38; 118; 229) depending on the occupancy state of the latter, characterized in that the measuring assembly (28; 48; 119; 119'; 228) is arranged in the processing position partially or completely in the positioning space (11; 111, 211) and the plurality of measuring elements (22, 23; 22'; 23'; 22"; 23"; 116; 117; 116'; 117'; 116"; 117"; 116′′′; 117′′′; 222, 223; 42) is an integral part of the sample receptacle assembly (20; 120; 120'; 120"; 220) and the dispensing means (18; 38; 118; 229) is an integral part of the base device (10; 110; 110'; 210).