A holding device for holding a plurality of primary packaging containers for pharmaceutical, medical or cosmetic compositions, the holding device comprising the plurality of primary packaging containers and a secondary packaging container which is designed and arranged for accommodating the plurality of primary packaging containers; wherein a. a plurality of holding elements of a first kind, and b. a plurality of holding elements of a further kind are arranged in the secondary packaging container; wherein the secondary packaging container, preferably, comprises A. a container opening, and B. a container base which is opposite to the container opening; wherein each holding element of the first kind is designed and arranged to detachably hold a primary packaging container of the plurality of primary packaging containers by contacting the primary packaging container at a first longitudinal position of the primary packaging container; wherein, for each holding element of the first kind, a holding element of the further kind is designed and arranged to restrict a movement of the primary packaging container, which is held by the holding element of the first kind, in a lateral direction of the primary packaging container, preferably in all lateral directions of the primary packaging container, at a further longitudinal position of the primary packaging container; wherein a distance between the first longitudinal position and the further longitudinal position of the primary packaging container is D; wherein the primary packaging container with the distance D has a length L; wherein 0.5. L < D < L; wherein each of the primary packaging containers comprises, in the following sequence along its length a) a first end part, comprising a discharge orifice, b) a body part, and c) a further end part, wherein the body part is of cylindrical shape; wherein each holding element of the first kind is designed and arranged to form a first positive fit with a primary packaging container of the plurality of primary packaging containers, which is being held by the respective holding element of the first kind, against a movement of this primary packaging container in a longitudinal direction; characterized in that for each holding element of the first kind, a holding element of the further kind is designed and arranged to form a further positive fit with the primary packaging container of the plurality of primary packaging containers, which is being held by the respective holding element of the first kind, against the movement of this primary packaging container in the longitudinal direction; and in that the first and further positive fits together prevent D from decreasing by more than 3 %. a. a plurality of holding elements of a first kind, and b. a plurality of holding elements of a further kind are arranged in the secondary packaging container; wherein the secondary packaging container, preferably, comprises A. a container opening, and B. a container base which is opposite to the container opening; A. a container opening, and B. a container base which is opposite to the container opening; wherein each holding element of the first kind is designed and arranged to detachably hold a primary packaging container of the plurality of primary packaging containers by contacting the primary packaging container at a first longitudinal position of the primary packaging container; wherein, for each holding element of the first kind, a holding element of the further kind is designed and arranged to restrict a movement of the primary packaging container, which is held by the holding element of the first kind, in a lateral direction of the primary packaging container, preferably in all lateral directions of the primary packaging container, at a further longitudinal position of the primary packaging container; wherein a distance between the first longitudinal position and the further longitudinal position of the primary packaging container is D; wherein the primary packaging container with the distance D has a length L; wherein 0.5. L < D < L; wherein each of the primary packaging containers comprises, in the following sequence along its length a) a first end part, comprising a discharge orifice, b) a body part, and c) a further end part, a) a first end part, comprising a discharge orifice, b) a body part, and c) a further end part, wherein the body part is of cylindrical shape; wherein each holding element of the first kind is designed and arranged to form a first positive fit with a primary packaging container of the plurality of primary packaging containers, which is being held by the respective holding element of the first kind, against a movement of this primary packaging container in a longitudinal direction; characterized in that for each holding element of the first kind, a holding element of the further kind is designed and arranged to form a further positive fit with the primary packaging container of the plurality of primary packaging containers, which is being held by the respective holding element of the first kind, against the movement of this primary packaging container in the longitudinal direction; and in that the first and further positive fits together prevent D from decreasing by more than 3 %.