A compound selected from Formula I: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein R 1 is selected from where the wavy line indicates the site of attachment; R 2 is selected from H, C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, -(C 1 -C 12 alkylene)-(C 3 -C 12 carbocyclyl), -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -(C 1 -C 12 alkylene)-C(=O)-(heterocyclyl with 3 to 20 ring atoms), -(C 1 -C 12 alkylene)-(C 6 -C 20 aryl), and -(C 1 -C 12 alkylene)-(heteroaryl with 5 to 20 ring atoms), where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CH 3, -CH 2 CH 3, -C(CH 3) 3, -CH 2 OH, - CH 2 CH 2 OH, -C(CH 3) 2 OH, -CH 2 OCH 3, -CN, -CF 3, -CO 2 H, -COCH 3, -COC(CH 3) 3,-CO 2 CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NO 2, -NH 2, -NHCH 3,-N(CH 3) 2, -NHCOCH 3, -NHS 2 CH 3, -N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, =O, -OH, -OCH 3, -S 2 N(CH 3) 2, -SCH 3, -S 2 CH 3, cyclopropyl, cyclobutyl, oxetanyl, morpholino, and 1,1-dioxo-thiopyran-4-yl; R 3 is a bicyclic heteroaryl group: where the wavy line indicates the site of attachment, and wherein R 8 is hydrogen, C 1 -C 12 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 3 -C 12 carbocyclyl, heterocyclyl with 3 to 20 ring atoms, C 6 -C 20 aryl, heteroaryl with 5 to 20 ring atoms, -(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -NH-(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), -N(C 1 -C 12 alkyl)-(C 1 -C 12 alkylene)-(heterocyclyl with 3 to 20 ring atoms), - NH-(heterocyclyl with 3 to 20 ring atoms), -O-(heterocyclyl with 3 to 20 ring atoms), -NH-(C 3 -C 12 carbocyclyl), -O-(C 3 -C 12 carbocyclyl), F, Cl, Br, I, -CN, -CO 2 H, -CONH 2,-CONH(C 1 -C 12 alkyl), -CON(C 1 -C 12 alkyl) 2, -CO(C 1 -C 12 alkyl), -NO 2, -NH 2, -NH(C 1 -C 12 alkyl), -N(C 1 -C 12 alkyl) 2, -NHCO(C 1 -C 12 alkyl), -NHS 2 (C 1 -C 12 alkyl), -N(C 1 -C 12 alkyl)S 2 (C 1 -C 12 alkyl), -OH, -O(C 1 -C 12 alkyl), -NHC(=O)NH(C 1 -C 12 alkyl), -SH, -S(C 1 -C 12 alkyl), -S (C 1 -C 12 alkyl), -S 2 (C 1 -C 12 alkyl), -S 2 NH 2, -S 2 NH(C 1 -C 12 alkyl), and -S 2 N(C 1 -C 12 alkyl) 2, where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CF 3, -CO 2 H, -COCH 3, -CO 2 CH 3, -CONH 2, -CONHCH 3,-CON(CH 3) 2, -NO 2, -NH 2, -NHCH 3, -NHCOCH 3, -NHS 2 CH 3, =O, -OH, -OCH 3,-S 2 N(CH 3) 2, -SH, -SCH 3, -CH 2 OCH 3, and -S 2 CH 3; R 9 is independently selected from F, Cl, Br, I, -CH 3, -CH 2 CH 3, -CH 2 CH 2 CH 3, -CH(CH 3) 2, -CH 2 CH(CH 3) 2, -CH 2 OH, -CH 2 CH 2 OH, -CN, -CF 3, -CO 2 H, -COCH 3,-CO 2 CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -NO 2, -NH 2, -NHCH 3, -NHCOCH 3,-NHS 2 CH 3, -OH, -OCH 3, -S 2 N(CH 3) 2, -SCH 3, -CH 2 OCH 3, and -S 2 CH 3; and n is 0, 1, 2, 3, or 4; R 4 is selected from H, F, Cl, Br, I, -CH 3, -CH 2 CH 3, -C(CH 3) 3, -CH 2 OH, -CH 2 CH 2 OH, -C(CH 3) 2 OH, -CN, -CF 3, -CO 2 H, -COCH 3, -CO 2 CH 3, -CONH 2, -CONHCH 3, -CON(CH 3) 2, -C(CH 3) 2 CONH 2, -NO 2, -NH 2, -NHCH 3, -N(CH 3) 2, -NHCOCH 3, -NHS 2 CH 3,-N(CH 3)C(CH 3) 2 CONH 2, -N(CH 3)CH 2 CH 2 S 2 CH 3, =O, -OH, -OCH 3, -S 2 N(CH 3) 2,-SCH 3, -CH 2 OCH 3, -S 2 CH 3; and n* is 0, 1, 2, 3, or 4.