A compound of Formula: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydroxypropyl, hydroxyethyl, ketopentyl, hydroxymethyl, pyridinylmethyl, oxazolylmethyl, methylisoxazolylmethyl, oxetanylmethyl, oxadiazolylmethyl, methyloxadiazolylmethyl, methoxyethyl, hydroxymethoxypropyl, methoxyketopropyl, ketomethylbutyl, ketopropyl, ketobutyl, acetamido, cyanomethyl, methylacetamido, trifluoroethyl, trifluoropropyl, or butynyl; R 2 is H or C 1 -C 6 alkyl; R 3 is phenyl, pyridyl, pyrimidinyl, pyrazinyl, or thiazolyl, each of which is substituted with (R 4) 1-2; R 4 is independently H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C l -C 3 haloalkyl, -N(R 8) 2, 3 to 8-membered cycloalkyl, aryl, heterocyclyl, heteroaryl, cyano, or halo, or two R 4 together with the atoms to which they are attached may form an optionally substituted 3 to 7-membered ring each of which is optionally substituted with (R 5) 1-3; R 5 is independently H, C 3 -C 10 heterocyclyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, -C 1 -C 6 alkyl-O-C 0 -C 6 alkyl, -C 0 -C 6 alkyl-O-C 1 -C 6 alkyl, -N(C 1 -C 3 alkyl) 2, C 1 -C 6 haloalkyl, -C 1 -C 3 alkyl-N(R 8) 2, heterocyclylalkyl, halo, cyano, or keto, each of which is optionally substituted with (R 7) 1-3; R 6 is H or C 1 -C 6 alkyl; R 7 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, hydroxy, aryl, heteroaryl, heterocyclyl, arylalkyl, aryloxy, heteroaryloxy, arylalkoxy, heteroarylalkoxy, heterarylalkyl, haloalkyl, keto, cyano, or halo, or two R 7 together with the atoms to which they are attached may form an optionally substituted 3 to 7-membered ring; and R 8 is H, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl. R 1 is hydroxypropyl, hydroxyethyl, ketopentyl, hydroxymethyl, pyridinylmethyl, oxazolylmethyl, methylisoxazolylmethyl, oxetanylmethyl, oxadiazolylmethyl, methyloxadiazolylmethyl, methoxyethyl, hydroxymethoxypropyl, methoxyketopropyl, ketomethylbutyl, ketopropyl, ketobutyl, acetamido, cyanomethyl, methylacetamido, trifluoroethyl, trifluoropropyl, or butynyl; R 2 is H or C 1 -C 6 alkyl; R 3 is phenyl, pyridyl, pyrimidinyl, pyrazinyl, or thiazolyl, each of which is substituted with (R 4) 1-2; R 4 is independently H, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C l -C 3 haloalkyl, -N(R 8) 2, 3 to 8-membered cycloalkyl, aryl, heterocyclyl, heteroaryl, cyano, or halo, or two R 4 together with the atoms to which they are attached may form an optionally substituted 3 to 7-membered ring each of which is optionally substituted with (R 5) 1-3; R 5 is independently H, C 3 -C 10 heterocyclyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, -C 1 -C 6 alkyl-O-C 0 -C 6 alkyl, -C 0 -C 6 alkyl-O-C 1 -C 6 alkyl, -N(C 1 -C 3 alkyl) 2, C 1 -C 6 haloalkyl, -C 1 -C 3 alkyl-N(R 8) 2, heterocyclylalkyl, halo, cyano, or keto, each of which is optionally substituted with (R 7) 1-3; R 6 is H or C 1 -C 6 alkyl; R 7 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, hydroxy, aryl, heteroaryl, heterocyclyl, arylalkyl, aryloxy, heteroaryloxy, arylalkoxy, heteroarylalkoxy, heterarylalkyl, haloalkyl, keto, cyano, or halo, or two R 7 together with the atoms to which they are attached may form an optionally substituted 3 to 7-membered ring; and R 8 is H, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl.