A profile section (10, 10', 10", 110, 210, 310, 410) molded by multi-shot injection molding of thermoplastic materials of different hardnesses forming a seal or trim molding for automotive vehicle bodywork (1a, 2a), the profile section comprising at least: - an antifriction covering (13, 13', 13", 113, 213, 313a, 313b, 413a, 413b) intimately bonded to a longitudinal sealing face (12a, 12a', 12a") of the profile section and intended to provide sealed contact with a mobile element (1b, 2b) of the vehicle, this sealing face terminating substantially at right angles at its respective longitudinal ends in two sealing transverse edge faces of the profile section, and/or - an embellishing film (14, 14', 14", 114, 314, 414) intimately bonded to a visible longitudinal face (11c, 11c', 11c") of the profile section mounted on the vehicle and intended to heighten the appearance of this visible face, which face is distinct from said sealing face and terminates substantially at right angles at its respective longitudinal ends in two visible transverse edge faces of the profile section, characterized in that said materials are overmolded: (i) either on said at least one covering or on said at least one film, which covering/s or which film/s is/are also intimately bonded continuously by this overmolding to at least one of said sealing edge faces or to at least one of said visible edge faces, respectively, (ii) or both to said at least one covering and to said at least one film, which covering/s and which film/s are optionally also intimately bonded continuously by this overmolding to at least one of said sealing edge faces and to at least one of said visible edge faces, respectively. - an antifriction covering (13, 13', 13", 113, 213, 313a, 313b, 413a, 413b) intimately bonded to a longitudinal sealing face (12a, 12a', 12a") of the profile section and intended to provide sealed contact with a mobile element (1b, 2b) of the vehicle, this sealing face terminating substantially at right angles at its respective longitudinal ends in two sealing transverse edge faces of the profile section, and/or - an embellishing film (14, 14', 14", 114, 314, 414) intimately bonded to a visible longitudinal face (11c, 11c', 11c") of the profile section mounted on the vehicle and intended to heighten the appearance of this visible face, which face is distinct from said sealing face and terminates substantially at right angles at its respective longitudinal ends in two visible transverse edge faces of the profile section, characterized in that said materials are overmolded: (i) either on said at least one covering or on said at least one film, which covering/s or which film/s is/are also intimately bonded continuously by this overmolding to at least one of said sealing edge faces or to at least one of said visible edge faces, respectively, (ii) or both to said at least one covering and to said at least one film, which covering/s and which film/s are optionally also intimately bonded continuously by this overmolding to at least one of said sealing edge faces and to at least one of said visible edge faces, respectively. (i) either on said at least one covering or on said at least one film, which covering/s or which film/s is/are also intimately bonded continuously by this overmolding to at least one of said sealing edge faces or to at least one of said visible edge faces, respectively, (ii) or both to said at least one covering and to said at least one film, which covering/s and which film/s are optionally also intimately bonded continuously by this overmolding to at least one of said sealing edge faces and to at least one of said visible edge faces, respectively.