mhurhangee/ep-ind-claims huggingface dataset:
A detector tile, comprising: - a flat primary substrate; - a surface layer with a circuitry arrangement; wherein the surface layer is arranged on a front side of the primary substrate covering the primary substrate; and wherein the circuitry arrangement comprises a number of detector pixels providing a pixel array; wherein at least one connection opening is provided in the surface layer and the flat primary substrate at least at one edge of the detector tile, which connection opening is leading from the surface layer to the rear of the substrate for guiding electrical connection elements between the front side and the rear of the detector tiles; wherein at all circumferential edges of the detector tile, the surface layer comprises at least portions with pixels, which portions extend to the edge; and characterized in that at least a first number of first connection openings is provided on one edge of the substrate and at least a second number of second connection openings is provided on an opponent edge of the substrate; wherein the first number is provided with a first offset and the second number is provided with a second offset; wherein the first and the second offset are arranged such that, when projected onto each other, first and second connection openings are alternating. - a flat primary substrate; - a surface layer with a circuitry arrangement;
Ready to use catheter assembly comprising: a catheter package with an opening means; a catheter with a catheter shaft which is arranged in the catheter package so that a distal end of the catheter lies in the region of the opening means; and a protective sleeve which at least partly covers the catheter shaft, a first end of the protective sleeve is fixed to the distal end of the catheter, characterized in that the opening means has a defined maximum opening length, a second end of the protective sleeve is releasably connected with the catheter package near the maximum opening length of the opening means and the protective sleeve is in a retracted state. a catheter package with an opening means; a catheter with a catheter shaft which is arranged in the catheter package so that a distal end of the catheter lies in the region of the opening means; and a protective sleeve which at least partly covers the catheter shaft, a first end of the protective sleeve is fixed to the distal end of the catheter, characterized in that the opening means has a defined maximum opening length, a second end of the protective sleeve is releasably connected with the catheter package near the maximum opening length of the opening means and the protective sleeve is in a retracted state.
Motor vehicle headlight comprising a housing and a light module pivotably arranged in the housing, the light module and the housing being parts of a closed kinematic chain which determines the pivot position, an adjusting element which changes its shape depending on the temperature being arranged in the kinematic chain in such a way that it performs a temperature-dependent adjustment movement in the kinematic chain that compensates for a temperature-dependent change in length of the rest of the kinematic chain at least in part, characterized in that the adjusting element which changes its shape depending on the temperature is a metal composite strip consisting of two or more layers of metal having different thermal expansion coefficients, the metal composite strip being arranged such that its length is transverse to the adjustment movement, and the metal composite strip having at least two regions (26.1, 26.3; 26.2, 26.3) which are spaced apart from one another transversely to the adjustment movement, of which a first region (26.3) is fixedly held in a housing-side portion of the kinematic chain and of which at least one second region (26.1, 26.2) is held in a light-module-side portion of the kinematic chain.
A circuit comprising: a power amplifier comprising a main amplifier stage and a peaking amplifier stage, wherein an output of the peaking amplifier stage is coupled to an output of the main amplifier stage through an impedance inverter circuit, wherein the output of the peaking amplifier stage is coupled to an output terminal of the power amplifier, the power amplifier producing an output voltage on the output terminal, wherein the main amplifier stage comprises a first power supply terminal and the peaking amplifier stage comprises a second power supply terminal; a power supply circuit coupled to the first power supply terminal and the second power supply terminal to provide one or more dynamic supply voltages to the main amplifier stage and to the peaking amplifier stage; and a bias circuit to bias the peaking amplifier stage, wherein a bias voltage produced by the bias circuit to the peaking amplifier increases as a voltage on the second power supply terminal decreases, wherein the bias circuit comprises an input coupled to the second power supply terminal and an output coupled to an input of the peaking amplifier stage. a power amplifier comprising a main amplifier stage and a peaking amplifier stage, wherein an output of the peaking amplifier stage is coupled to an output of the main amplifier stage through an impedance inverter circuit, wherein the output of the peaking amplifier stage is coupled to an output terminal of the power amplifier, the power amplifier producing an output voltage on the output terminal, wherein the main amplifier stage comprises a first power supply terminal and the peaking amplifier stage comprises a second power supply terminal; a power supply circuit coupled to the first power supply terminal and the second power supply terminal to provide one or more dynamic supply voltages to the main amplifier stage and to the peaking amplifier stage; and a bias circuit to bias the peaking amplifier stage, wherein a bias voltage produced by the bias circuit to the peaking amplifier increases as a voltage on the second power supply terminal decreases, wherein the bias circuit comprises an input coupled to the second power supply terminal and an output coupled to an input of the peaking amplifier stage.
An anti-cancer agent for use in a method of treating a subject having a colorectal cancer having a Kinesin Family Member 5B - RET proto-oncogene (KIF5B-RET) fusion, wherein the method comprises: administering to the subject an effective amount of the anti-cancer agent, thereby treating colorectal cancer in the subject, wherein the anti-cancer agent is selected from: (i) a multi-kinase inhibitor or a RET-specific inhibitor; or (ii) a nucleic acid molecule selected from the group consisting of antisense molecules, ribozymes, siRNA, and triple helix molecules, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule encoding the KIF5B-RET fusion, thereby blocking or reducing mRNA expression of the nucleic acid molecule encoding the KIF5B-RET fusion. administering to the subject an effective amount of the anti-cancer agent, thereby treating colorectal cancer in the subject, wherein the anti-cancer agent is selected from: (i) a multi-kinase inhibitor or a RET-specific inhibitor; or (ii) a nucleic acid molecule selected from the group consisting of antisense molecules, ribozymes, siRNA, and triple helix molecules, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule encoding the KIF5B-RET fusion, thereby blocking or reducing mRNA expression of the nucleic acid molecule encoding the KIF5B-RET fusion. (i) a multi-kinase inhibitor or a RET-specific inhibitor; or (ii) a nucleic acid molecule selected from the group consisting of antisense molecules, ribozymes, siRNA, and triple helix molecules, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule encoding the KIF5B-RET fusion, thereby blocking or reducing mRNA expression of the nucleic acid molecule encoding the KIF5B-RET fusion.
A mobile station configured to establish uplink synchronization, wherein the mobile station is configured not to return transmission acknowledgment information for downlink data until receiving a command for adjusting uplink transmission timing (S3, S5), when a radio base station (eNB) allocates a radio resource for transmission of the downlink data to the mobile station, wherein the radio resource is allocated by use of an identifier, whereby the identifier identifies a dedicated preamble and the preamble individually identifies the mobile station within a cell, characterized in that the mobile station is further configured to transmit the preamble using the random access channel in response to downlink data included in the downlink data channel received from the radio base station (eNB), when downlink data from the radio base station (eNB) is received before the command for adjusting uplink transmission timing. the mobile station is configured not to return transmission acknowledgment information for downlink data until receiving a command for adjusting uplink transmission timing (S3, S5), when a radio base station (eNB) allocates a radio resource for transmission of the downlink data to the mobile station, wherein the radio resource is allocated by use of an identifier, whereby the identifier identifies a dedicated preamble and the preamble individually identifies the mobile station within a cell, characterized in that the mobile station is further configured to transmit the preamble using the random access channel in response to downlink data included in the downlink data channel received from the radio base station (eNB), when downlink data from the radio base station (eNB) is received before the command for adjusting uplink transmission timing.
An electrical supply line, comprising: - two conductors (12a, 12b), - an insulating coating, protecting the conductors (12a, 12b), - the conductors (12a, 12b) are each formed by a flat aluminium strip, - the insulating coating is formed by a first flat band and a second flat band, the first flat band and the second flat band sandwiching the conductors (12a, 12b), - the first flat band further comprises an adhesive layer in order to enable the supply line to be affixed to a support, characterised in that it comprises at least one protective tape (16a, 16b), disposed between each conductor (12a, 12b) and the second flat band of said insulating coating. - two conductors (12a, 12b), - an insulating coating, protecting the conductors (12a, 12b), - the conductors (12a, 12b) are each formed by a flat aluminium strip, - the insulating coating is formed by a first flat band and a second flat band, the first flat band and the second flat band sandwiching the conductors (12a, 12b), - the first flat band further comprises an adhesive layer in order to enable the supply line to be affixed to a support,
: Pharmaceutical composition comprising - a soluble matrix precursor, wherein the soluble matrix precursor is an alginate, collagen, hyaluronic acid, fibrinogen, gelatin, chondroitin sulfate or combinations thereof, - an ultrasound transfection agent, - a pharmaceutically active nucleic acid, and - target cells for the pharmaceutically active nucleic acid, wherein the target cells are primary cells, expanded cells or a stromal cell fraction, especially fibroblasts, bone progenitor cells or adult mesenchymal stem cells. - a soluble matrix precursor, wherein the soluble matrix precursor is an alginate, collagen, hyaluronic acid, fibrinogen, gelatin, chondroitin sulfate or combinations thereof, - an ultrasound transfection agent, - a pharmaceutically active nucleic acid, and - target cells for the pharmaceutically active nucleic acid, wherein the target cells are primary cells, expanded cells or a stromal cell fraction, especially fibroblasts, bone progenitor cells or adult mesenchymal stem cells.
Machine tool with a spindle assembly and a workpiece carrier, wherein the spindle assembly has at least one tool spindle for holding a machining tool, wherein the workpiece carrier has at least two workpiece holding areas (65A, 65B), each having at least one workpiece holder for holding a workpiece, wherein the workpiece carrier and the tool spindle or spindles is or are adjustable relative to one another along a machining axis, in particular horizontal, for machining at least one workpiece held on the workpiece carrier with the aid of the machining tool, wherein the machine tool has a workpiece changeover unit for loading the workpiece carrier with workpieces and for unloading the workpiece carrier, and wherein the machine tool has an adjusting device for adjusting the workpiece holding areas (65A, 65B) of the workpiece carrier between a machining position facing the spindle assembly, for machining at least one workpiece held in the respective workpiece holding area (65A, 65B), and a workpiece changeover position facing the workpiece changeover unit, for changeover of workpieces by the workpiece changeover unit, characterised in that it has a control unit for driving the machine tool in such a way that the workpiece changeover unit, during machining of workpieces held in a workpiece holding area (65A, 65B) of the workpiece carrier by the spindle assembly in a first machining mode, simultaneously changes workpieces held in the other workpiece holding area (65A, 65B) of the workpiece carrier and, during machining of workpieces held in a workpiece holding area (65A, 65B) in a second machining mode, in which the spindle assembly machines a respective workpiece with a higher requirement for a rest position of the workpiece carrier as compared with the first machining mode, fits no workpieces to the workpiece carrier nor removes them from the workpiece carrier.
A transfer device for transferring a medical fluid from a vial to a medical fluid injection device comprising: a) a vial elevator configured to receive a vial containing a medical fluid b) a vial elevator shaft within which the vial elevator moves between an extended position and a retracted position, wherein the vial elevator shaft includes shaft cam ramps and the vial elevator includes a plurality of locking arms that are moved radially inwards by the shaft cam ramps as the vial elevator is moved towards the retracted position, each of said locking arms including a locking shoulder configured to engage a vial inserted in the vial elevator when the vial elevator is in the retracted position; c) a vial spike positioned within the vial elevator shaft so that the vial spike is positioned within the vial when the vial elevator is in the retracted position; d) an expansion chamber having an interior cavity; e) a pressurized gas cartridge positioned with the interior cavity of the expansion chamber; f) a puncture tip configured to puncture the pressurized gas cartridge when actuated by a user; and g) said vial spike in fluid communication with the interior cavity of the expansion chamber and configured to be in fluid communication with an injection device attached to the transfer device and a vial positioned within the vial elevator when the vial elevator is in the retracted position and the vial spike is positioned in the vial. a) a vial elevator configured to receive a vial containing a medical fluid b) a vial elevator shaft within which the vial elevator moves between an extended position and a retracted position, wherein the vial elevator shaft includes shaft cam ramps and the vial elevator includes a plurality of locking arms that are moved radially inwards by the shaft cam ramps as the vial elevator is moved towards the retracted position, each of said locking arms including a locking shoulder configured to engage a vial inserted in the vial elevator when the vial elevator is in the retracted position; c) a vial spike positioned within the vial elevator shaft so that the vial spike is positioned within the vial when the vial elevator is in the retracted position; d) an expansion chamber having an interior cavity; e) a pressurized gas cartridge positioned with the interior cavity of the expansion chamber; f) a puncture tip configured to puncture the pressurized gas cartridge when actuated by a user; and g) said vial spike in fluid communication with the interior cavity of the expansion chamber and configured to be in fluid communication with an injection device attached to the transfer device and a vial positioned within the vial elevator when the vial elevator is in the retracted position and the vial spike is positioned in the vial.
A system comprising a plurality of outdoor power tools and an activity monitoring device comprising processing circuitry, said activity monitoring device being connected to the plurality of outdoor power tools and the first outdoor power tool being selected from a group consisting of trimmers and chainsaws, wherein each of said plurality of outdoor power tools comprises movement sensor circuitry, and wherein said processing circuitry being configured to: define a predefined work pattern based on indications of device activity of the plurality of outdoor power tools; receive indications of device activity of the plurality of outdoor power tools, the indications of device activity comprising parametric changes and movements; determine whether the device activity correlates to the predefined work pattern, the work pattern including a series of activities; in response to the device activity correlating to the predefined work pattern, determine a set of instructions associated with the predefined work pattern; and initiate provision of the set of instructions to define a programmed response to the predefined work pattern, wherein the each of the plurality of outdoor power tools comprises onboard circuitry capable of communication with a network and wherein receiving the indications of device activity comprises receiving the indications remotely through the network at a computing device comprising the activity monitoring device, the computing device being an application server and wherein the processing circuitry is configured to enable automated pattern learning define a predefined work pattern based on indications of device activity of the plurality of outdoor power tools; receive indications of device activity of the plurality of outdoor power tools, the indications of device activity comprising parametric changes and movements; determine whether the device activity correlates to the predefined work pattern, the work pattern including a series of activities; in response to the device activity correlating to the predefined work pattern, determine a set of instructions associated with the predefined work pattern; and initiate provision of the set of instructions to define a programmed response to the predefined work pattern, wherein the each of the plurality of outdoor power tools comprises onboard circuitry capable of communication with a network and wherein receiving the indications of device activity comprises receiving the indications remotely through the network at a computing device comprising the activity monitoring device, the computing device being an application server and wherein the processing circuitry is configured to enable automated pattern learning
Process for preparing a poly(meth)acrylic acid, characterized in that a process stream from (meth)acrolein synthesis containing between 8 and 50% by weight of (meth)acrylic acid, based on the weight of the process stream, is subjected to free-radical polymerization in the presence of water formed in the oxidation reaction of the meth(acrolein) synthesis.
A stage comprising: a first supporting plate; a second supporting plate under the first supporting plate a shaft located under the second supporting plate and overlapping with the first supporting plate and the second supporting plate; and at least one sheath heater passing through the second supporting plate and arranged so as to extend on a first plane and a second plane which are parallel to an upper surface of the second supporting plate and which are different in distance from the first supporting plate wherein an upper section of the sheath heater extending on the first plane is exposed from the upper surface of the second supporting plate, and a lower section of the sheath heater extending on the second plane is exposed from a lower surface of the second supporting plate a first supporting plate; a second supporting plate under the first supporting plate a shaft located under the second supporting plate and overlapping with the first supporting plate and the second supporting plate; and at least one sheath heater passing through the second supporting plate and arranged so as to extend on a first plane and a second plane which are parallel to an upper surface of the second supporting plate and which are different in distance from the first supporting plate wherein an upper section of the sheath heater extending on the first plane is exposed from the upper surface of the second supporting plate, and a lower section of the sheath heater extending on the second plane is exposed from a lower surface of the second supporting plate
Method of producing a pharmaceutical preparation that contains a PPI (proton pump inhibitor) in the form of spherical granules (pellets), comprising the following steps: (a) granulating the PPI, at least one basic component, at least one pharmaceutically acceptable excipient, and at least one alcohol, preferably ethanol and/or isopropanol, in particular isopropanol, using a high-speed mixer, to obtain PPI-containing cores, (b) drying the cores, (c) coating the dried cores with an inert intermediate layer, (d) film-coating the coated cores with an enteric layer, and (e) drying the enteric film-coated cores to a residual moisture of less than or equal to 1.5 wt.-%, preferably less than or equal to 1 wt.%, to obtain PPI pellets, wherein the impeller blade speed of the high-speed mixer is greater than or equal to 50 rev/min, is preferably greater than or equal to 65 rev/min, more preferably is in the range from 70 to 140 rev/min, the granulation time is preferably less than 20 minutes, more preferably less than or equal to 10 minutes, particularly preferably less than or equal to 8 minutes and most preferably 5 to 8 minutes, and the granulating (a) takes place in the absence of water. (a) granulating the PPI, at least one basic component, at least one pharmaceutically acceptable excipient, and at least one alcohol, preferably ethanol and/or isopropanol, in particular isopropanol, using a high-speed mixer, to obtain PPI-containing cores, (b) drying the cores, (c) coating the dried cores with an inert intermediate layer, (d) film-coating the coated cores with an enteric layer, and (e) drying the enteric film-coated cores to a residual moisture of less than or equal to 1.5 wt.-%, preferably less than or equal to 1 wt.%, to obtain PPI pellets,