A system for irradiation of a vascular space and its contents, comprising: an adapter device comprising: a central section having a first end and second end, the central section comprising: a central lumen extending from the first end to the second end; an engaging protrusion at the second end; and a fluid port configured to introduce an exogenous fluid into the central lumen; a vascular access portion extending from the first end of the central section, comprising an access lumen in fluid communication with the central lumen; a tapered end extending from the second end of the central section, the tapered end including a waveguide lumen aligned with the central lumen and the access lumen and wherein the waveguide lumen is fluidly isolated from the central lumen; and a waveguide housed within the waveguide lumen, wherein the waveguide includes a first end having a first face that is approximately flush with the tapered end and extends through the central lumen and the access lumen; and an optical connector adapter having an adapter end and an interface end comprising: a tapered cavity extending inwardly from the adapter end, the tapered cavity configured to receive the tapered end of the adapter device, an interface cavity extending inwardly from the interface end, the interface cavity configured to receive a source interface including a source waveguide having an engagement end comprising a second face, wherein the interface cavity is aligned with the tapered cavity, and wherein the tapered end is configured to provide alignment of the first end of the waveguide relative to the tapered cavity such that the first end of the waveguide of an inserted tapered end is optically aligned with the engagement end of the source waveguide of an inserted source interface such that the first face of the waveguide is within 0.0762 mm of the second face of the engagement end of the source waveguide and the first face of the waveguide and the second face of the engagement end of the source waveguide are within 10° of parallel to one another when the tapered cavity is engaged with the tapered end of the adapter device; and a slip lock ring rotatably coupled to the adapter end, the slip lock ring including internal threading configured to engage with the engaging protrusion of the second end of the central section. an adapter device comprising: a central section having a first end and second end, the central section comprising: a central lumen extending from the first end to the second end; an engaging protrusion at the second end; and a fluid port configured to introduce an exogenous fluid into the central lumen; a vascular access portion extending from the first end of the central section, comprising an access lumen in fluid communication with the central lumen; a tapered end extending from the second end of the central section, the tapered end including a waveguide lumen aligned with the central lumen and the access lumen and wherein the waveguide lumen is fluidly isolated from the central lumen; and a waveguide housed within the waveguide lumen, wherein the waveguide includes a first end having a first face that is approximately flush with the tapered end and extends through the central lumen and the access lumen; and a central section having a first end and second end, the central section comprising: a central lumen extending from the first end to the second end; an engaging protrusion at the second end; and a fluid port configured to introduce an exogenous fluid into the central lumen; a vascular access portion extending from the first end of the central section, comprising an access lumen in fluid communication with the central lumen; a tapered end extending from the second end of the central section, the tapered end including a waveguide lumen aligned with the central lumen and the access lumen and wherein the waveguide lumen is fluidly isolated from the central lumen; and a waveguide housed within the waveguide lumen, wherein the waveguide includes a first end having a first face that is approximately flush with the tapered end and extends through the central lumen and the access lumen; and an optical connector adapter having an adapter end and an interface end comprising: a tapered cavity extending inwardly from the adapter end, the tapered cavity configured to receive the tapered end of the adapter device, an interface cavity extending inwardly from the interface end, the interface cavity configured to receive a source interface including a source waveguide having an engagement end comprising a second face, wherein the interface cavity is aligned with the tapered cavity, and wherein the tapered end is configured to provide alignment of the first end of the waveguide relative to the tapered cavity such that the first end of the waveguide of an inserted tapered end is optically aligned with the engagement end of the source waveguide of an inserted source interface such that the first face of the waveguide is within 0.0762 mm of the second face of the engagement end of the source waveguide and the first face of the waveguide and the second face of the engagement end of the source waveguide are within 10° of parallel to one another when the tapered cavity is engaged with the tapered end of the adapter device; and a slip lock ring rotatably coupled to the adapter end, the slip lock ring including internal threading configured to engage with the engaging protrusion of the second end of the central section.