A compound of the Formula: wherein: R 3 and R 4 are taken together to form a fused benzene ring, a fused pyridine ring, a fused cyclohexene ring, or a fused tetrahydropyridine ring; wherein the fused benzene ring, fused pyridine ring, fused cyclohexene ring, or fused tetrahydropyridine ring is either unsubstituted or substituted by one or more R groups; R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, haloalkyl, -C -O-alkyl, -C -OCH 2 Ph, -C -O-aryl, amino, alkylamino, dialkylamino, aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl heteroarylalkyleneoxy, and heteroaryloxy, wherein the alkyl, aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl heteroarylalkyleneoxy, and heteroaryloxy groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxyl, hydroxyalkylenyl, alkoxyalkylenyl, arylalkyleneoxy, nitrile, amino, alkylamino, and dialkylamino; R 1 is -W-X-N -C(=NH)-NH 2; W is selected from the group consisting of a covalent bond, -O-, and -NH-; X is selected from the group consisting of alkylene, alkenylene, and alkynylene, wherein any of the alkylene, alkenylene, and alkynylene groups can be optionally interrupted by one or more -O- groups; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, -O-alkyl, hydroxyalkylenyl, alkoxyalkylenyl, alkylaminoalkylenyl, hydroxyl, -CH 2 -NH-O-alkyl, and -CH 2 NHC -alkyl; wherein alkyl groups contain from 1 to 14 carbon atoms, haloalkyl groups are alkyl groups that are substituted by one or more halogen atoms, aryl groups are selected from phenyl, naphthyl, and biphenyl, heteroaryl groups are a ring or ring system that contains 2 to 12 carbon atoms, 1 to 3 rings, 1 to 4 heteroatoms with O, S, and N as the heteroatoms, alkenyl groups contain from 2 to 14 carbon atoms, alkynyl groups contain from 2 to 14 carbon atoms, cycloalkyl groups contain from 3 to 10 ring carbon atoms, and alkylene, alkenylene, and alkynylene are the diradical equivalents of alkyl, alkenyl, and alkynyl, or a pharmaceutically acceptable salt thereof. R 3 and R 4 are taken together to form a fused benzene ring, a fused pyridine ring, a fused cyclohexene ring, or a fused tetrahydropyridine ring; wherein the fused benzene ring, fused pyridine ring, fused cyclohexene ring, or fused tetrahydropyridine ring is either unsubstituted or substituted by one or more R groups; R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, haloalkyl, -C -O-alkyl, -C -OCH 2 Ph, -C -O-aryl, amino, alkylamino, dialkylamino, aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl heteroarylalkyleneoxy, and heteroaryloxy, wherein the alkyl, aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl heteroarylalkyleneoxy, and heteroaryloxy groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxyl, hydroxyalkylenyl, alkoxyalkylenyl, arylalkyleneoxy, nitrile, amino, alkylamino, and dialkylamino; R 1 is -W-X-N -C(=NH)-NH 2; W is selected from the group consisting of a covalent bond, -O-, and -NH-; X is selected from the group consisting of alkylene, alkenylene, and alkynylene, wherein any of the alkylene, alkenylene, and alkynylene groups can be optionally interrupted by one or more -O- groups; R 2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, -O-alkyl, hydroxyalkylenyl, alkoxyalkylenyl, alkylaminoalkylenyl, hydroxyl, -CH 2 -NH-O-alkyl, and -CH 2 NHC -alkyl; wherein alkyl groups contain from 1 to 14 carbon atoms, haloalkyl groups are alkyl groups that are substituted by one or more halogen atoms, aryl groups are selected from phenyl, naphthyl, and biphenyl, heteroaryl groups are a ring or ring system that contains 2 to 12 carbon atoms, 1 to 3 rings, 1 to 4 heteroatoms with O, S, and N as the heteroatoms, alkenyl groups contain from 2 to 14 carbon atoms, alkynyl groups contain from 2 to 14 carbon atoms, cycloalkyl groups contain from 3 to 10 ring carbon atoms, and alkylene, alkenylene, and alkynylene are the diradical equivalents of alkyl, alkenyl, and alkynyl, or a pharmaceutically acceptable salt thereof.