A prosthesis for placement within a body cavity, the prosthesis configured to inhibit or reduce paravalvular leakage, the prosthesis comprising: an expandable frame comprising a proximal end and a distal end and a longitudinal axis extending therethrough, the frame configured to radially expand and contract for deployment within the body cavity; an annular flap positioned around and secured to an exterior of the expandable frame, the annular flap having a distal edge secured at or near the distal end of the frame and extending to a proximal edge secured at an intermediate location on the frame between the proximal and distal ends (22, 24); a valve body positioned within an interior of the expandable frame, wherein the valve body comprises: an inner skirt secured to the interior of the expandable frame, and a plurality of leaflets configured to allow flow in a first direction and prevent flow in a second opposite direction; wherein an opening is defined at or near the distal end of the frame between the annular flap and the valve body to provide access for fluid to flow into a space between the annular flap and the valve body, and wherein fluid flow into the space causes the annular flap to move from a first configuration wherein the flap is closer to the frame to a second configuration wherein the flap is spaced further away from the frame to increase the surface area of the prosthesis and create a barrier to fluid flow exterior to the frame when deployed within the body cavity; and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein all of the plurality of the distal anchors comprise a cushion (38, 39), characterized in that one or more of the distal anchors of the plurality comprise thicker cushions and the rest of the distal anchors of the plurality comprise thinner cushions covering the distal anchors, wherein the thicker cushions are thicker than the thinner cushions. an expandable frame comprising a proximal end and a distal end and a longitudinal axis extending therethrough, the frame configured to radially expand and contract for deployment within the body cavity; an annular flap positioned around and secured to an exterior of the expandable frame, the annular flap having a distal edge secured at or near the distal end of the frame and extending to a proximal edge secured at an intermediate location on the frame between the proximal and distal ends (22, 24); a valve body positioned within an interior of the expandable frame, wherein the valve body comprises: an inner skirt secured to the interior of the expandable frame, and a plurality of leaflets configured to allow flow in a first direction and prevent flow in a second opposite direction; an inner skirt secured to the interior of the expandable frame, and a plurality of leaflets configured to allow flow in a first direction and prevent flow in a second opposite direction; wherein an opening is defined at or near the distal end of the frame between the annular flap and the valve body to provide access for fluid to flow into a space between the annular flap and the valve body, and wherein fluid flow into the space causes the annular flap to move from a first configuration wherein the flap is closer to the frame to a second configuration wherein the flap is spaced further away from the frame to increase the surface area of the prosthesis and create a barrier to fluid flow exterior to the frame when deployed within the body cavity; and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein all of the plurality of the distal anchors comprise a cushion (38, 39), characterized in that one or more of the distal anchors of the plurality comprise thicker cushions and the rest of the distal anchors of the plurality comprise thinner cushions covering the distal anchors, wherein the thicker cushions are thicker than the thinner cushions.