mhurhangee/ep-ind-claims huggingface dataset:
An oligosaccharide-lysosomal enzyme conjugate for use in treating a lysosomal storage disorder in a subject in need thereof, comprising: a lysosomal enzyme, an oligosaccharide, and an oxime group connecting the lysosomal enzyme and the oligosaccharide, wherein the oligosaccharide is an oligosaccharide of Formula VI: or an oligosaccharide of Formula IV: wherein m and p are independently chosen from integers ranging from 1 to 10, wherein: (i) the lysosomal enzyme is acid alpha-glucosidase, and the lysosomal storage disorder is Pompe disease; (ii) the lysosomal enzyme is alpha-galactosidase A, and the lysosomal storage disorder is Fabry disease; (iii) the lysosomal enzyme is acid sphingomyelinase, and the lysosomal storage disorder is Niemann-Pick disease; (iv) the lysosomal enzyme is alpha-L-iduronidase, and the lysosomal storage disorder is mucopolysaccharidosis I. or an oligosaccharide of Formula IV: wherein m and p are independently chosen from integers ranging from 1 to 10, wherein: (i) the lysosomal enzyme is acid alpha-glucosidase, and the lysosomal storage disorder is Pompe disease; (ii) the lysosomal enzyme is alpha-galactosidase A, and the lysosomal storage disorder is Fabry disease; (iii) the lysosomal enzyme is acid sphingomyelinase, and the lysosomal storage disorder is Niemann-Pick disease; (iv) the lysosomal enzyme is alpha-L-iduronidase, and the lysosomal storage disorder is mucopolysaccharidosis I. (i) the lysosomal enzyme is acid alpha-glucosidase, and the lysosomal storage disorder is Pompe disease; (ii) the lysosomal enzyme is alpha-galactosidase A, and the lysosomal storage disorder is Fabry disease; (iii) the lysosomal enzyme is acid sphingomyelinase, and the lysosomal storage disorder is Niemann-Pick disease; (iv) the lysosomal enzyme is alpha-L-iduronidase, and the lysosomal storage disorder is mucopolysaccharidosis I.
A system (200, 300), comprising; a plurality of first sources (240, 340); a front float (232,332,432,532) coupled to the plurality of first sources (240,340), the front float (232, 332, 432, 532) comprising: a plurality of winches configured to adjust positions of the plurality of first sources (240, 340); and a control unit configured to control functions associated with the front float (232, 332, 432, 532); a streamer (206, 306) connected to a lead-in (226, 326) at a first connection point (294, 394) on a spreader line (120, 220); a first cable (253, 353) coupled between the front float (232, 332, 432, 532) and the connection point (294, 394); a second source (250, 350); a second cable coupled between the first connection point (294, 394) and the second source (250, 350); and a plurality of third cables (255, 355) each coupled to the front float (232, 332, 432, 532) and to a respective source of the plurality of first sources (240, 340) and configured to accommodate transfer of electrical energy between the front float (232, 332, 432, 532) and the respective source (240, 340). a plurality of first sources (240, 340); a front float (232,332,432,532) coupled to the plurality of first sources (240,340), the front float (232, 332, 432, 532) comprising: a plurality of winches configured to adjust positions of the plurality of first sources (240, 340); and a control unit configured to control functions associated with the front float (232, 332, 432, 532); a plurality of winches configured to adjust positions of the plurality of first sources (240, 340); and a control unit configured to control functions associated with the front float (232, 332, 432, 532); a streamer (206, 306) connected to a lead-in (226, 326) at a first connection point (294, 394) on a spreader line (120, 220); a first cable (253, 353) coupled between the front float (232, 332, 432, 532) and the connection point (294, 394); a second source (250, 350); a second cable coupled between the first connection point (294, 394) and the second source (250, 350); and a plurality of third cables (255, 355) each coupled to the front float (232, 332, 432, 532) and to a respective source of the plurality of first sources (240, 340) and configured to accommodate transfer of electrical energy between the front float (232, 332, 432, 532) and the respective source (240, 340).
A discharge tube for a lamp comprising: a body portion including a first end, a second end, and a tubular member defining an interior area, wherein the tubular member extends along an elongated axis between the first end and the second end; and a first end portion provided at the first end of the body portion, the first end portion including a first tubular extension having a first through passage in communication with the interior area, the first end portion further including a first transition section connected between the first tubular extension and the body portion, wherein the first transition section comprises a tapered portion that is tapered in a direction extending substantially perpendicular from the elongated axis wherein the tapered portion includes an interior surface facing the interior area and the tapered portion spans between a maximum extent in the direction of the elongated axis and a minimum extent in the direction of the elongated axis, the minimum extent having a first dimension D 1 with respect to the interior surface and the maximum extent having a second dimension D 2 with respect to the interior surface, characterized in that the ratio D 1 /D 2 is from 0.07 to 0.43, wherein the first end portion is configured such that the temperature differential within the transition section does not exceed 20 Kelvin when cooling the discharge tube from a temperature of from 1100 Kelvin in air at a temperature of 300 Kelvin. a body portion including a first end, a second end, and a tubular member defining an interior area, wherein the tubular member extends along an elongated axis between the first end and the second end; and a first end portion provided at the first end of the body portion, the first end portion including a first tubular extension having a first through passage in communication with the interior area, the first end portion further including a first transition section connected between the first tubular extension and the body portion, wherein the first transition section comprises a tapered portion that is tapered in a direction extending substantially perpendicular from the elongated axis wherein the tapered portion includes an interior surface facing the interior area and the tapered portion spans between a maximum extent in the direction of the elongated axis and a minimum extent in the direction of the elongated axis, the minimum extent having a first dimension D 1 with respect to the interior surface and the maximum extent having a second dimension D 2 with respect to the interior surface, characterized in that the ratio D 1 /D 2 is from 0.07 to 0.43, wherein the first end portion is configured such that the temperature differential within the transition section does not exceed 20 Kelvin when cooling the discharge tube from a temperature of from 1100 Kelvin in air at a temperature of 300 Kelvin.
Decoration and control line for products, in particular ceramic tiles and the like, comprising: a conveyor of the products to be decorated; at least one decorating machine of the jet type actuated by piezoelectrically controlled nozzles, suitable for applying at least one layer of enamel onto the products passing on said conveyor; at least one control and diagnostics module of the decorated products, equipped with means for identifying decorative and/or structural defects of the products themselves, wherein said control and diagnostics module comprises lighting means (12, 13, 14) for illuminating the decorated products, said means being suitable for emitting according to various frequencies, said means for identifying defects comprise at least one viewing device, characterised in that said viewing device is configured to capture an image of the decorated product suitably lighted by one or more of said light means, wherein said means for identifying defects comprise means for detecting at least one chromatic peak in the image of a product captured by said viewing device. a conveyor of the products to be decorated; at least one decorating machine of the jet type actuated by piezoelectrically controlled nozzles, suitable for applying at least one layer of enamel onto the products passing on said conveyor; at least one control and diagnostics module of the decorated products, equipped with means for identifying decorative and/or structural defects of the products themselves, wherein said control and diagnostics module comprises lighting means (12, 13, 14) for illuminating the decorated products, said means being suitable for emitting according to various frequencies, said means for identifying defects comprise at least one viewing device, characterised in that said viewing device is configured to capture an image of the decorated product suitably lighted by one or more of said light means, wherein said means for identifying defects comprise means for detecting at least one chromatic peak in the image of a product captured by said viewing device.
A physical resource block, PRB, grid indication method, performed by a terminal device or a chip for the terminal device, comprising: receiving location information from a network device, wherein the location information is used to indicate a relative location relationship between a first predetermined location in a synchronization signal block PRB grid and a PRB in a system common PRB grid with a first subcarrier spacing, wherein the PRB in the system common PRB grid is a PRB where the first predetermined location in the synchronization signal block PRB grid is located; and determining a location of a PRB comprised in the system common PRB grid based on the first predetermined location and the location information; wherein that the location information is used to indicate a relative location relationship between a first predetermined location in a synchronization signal block PRB grid and a PRB in a system common PRB grid with a first subcarrier spacing is specifically: the location information is used to indicate that the first predetermined location and a second predetermined location of the PRB have an offset of M subcarrier spacings, wherein M is a natural number greater than or equal to 0. receiving location information from a network device, wherein the location information is used to indicate a relative location relationship between a first predetermined location in a synchronization signal block PRB grid and a PRB in a system common PRB grid with a first subcarrier spacing, wherein the PRB in the system common PRB grid is a PRB where the first predetermined location in the synchronization signal block PRB grid is located; and determining a location of a PRB comprised in the system common PRB grid based on the first predetermined location and the location information; wherein that the location information is used to indicate a relative location relationship between a first predetermined location in a synchronization signal block PRB grid and a PRB in a system common PRB grid with a first subcarrier spacing is specifically: the location information is used to indicate that the first predetermined location and a second predetermined location of the PRB have an offset of M subcarrier spacings, wherein M is a natural number greater than or equal to 0.
A keyboard switch comprising: a key top movable vertically on receiving a depressing force; a plunger engaged with a lower portion of the key top and movable vertically with the key top; a cup rubber disposed under the plunger and supporting the plunger from below; a housing arranged on an outer peripheral side of the plunger and the cup rubber; a plate supported on the housing and extending laterally; and a spacer (15, 115, 225) interposed between the plate and the key top, wherein the spacer (15, 115, 225) is removably mounted such that an operator can freely mount or remove it. a key top movable vertically on receiving a depressing force; a plunger engaged with a lower portion of the key top and movable vertically with the key top; a cup rubber disposed under the plunger and supporting the plunger from below; a housing arranged on an outer peripheral side of the plunger and the cup rubber; a plate supported on the housing and extending laterally; and a spacer (15, 115, 225) interposed between the plate and the key top, wherein the spacer (15, 115, 225) is removably mounted such that an operator can freely mount or remove it.
An electrostatic rotary sprayer for coating product, this sprayer comprising: - a spraying cup; - a body; - a drive turbine assembled in the body and configured to rotate the spraying cup about an axis of rotation defined by the body; - electrodes for charging the coating product sprayed by the spraying cup, these electrodes being assembled on a ring attached on the body; - a skirt for discharging air around the cup; and wherein an annular slit, supplied by a pressurized air flow circuit with pressurized air, is defined radially between the ring and the skirt, with its outlet oriented toward the front of the sprayer and the pressurized air flow circuit toward the annular slit comprises at least one chamber (V102, 224, 226) defined between the body and the skirt or between the ring and the skirt, and characterized in that the chamber forms a baffle around a rear rim of the skirt. - a spraying cup; - a body; - a drive turbine assembled in the body and configured to rotate the spraying cup about an axis of rotation defined by the body; - electrodes for charging the coating product sprayed by the spraying cup, these electrodes being assembled on a ring attached on the body; - a skirt for discharging air around the cup; and wherein an annular slit, supplied by a pressurized air flow circuit with pressurized air, is defined radially between the ring and the skirt, with its outlet oriented toward the front of the sprayer and the pressurized air flow circuit toward the annular slit comprises at least one chamber (V102, 224, 226) defined between the body and the skirt or between the ring and the skirt, and characterized in that the chamber forms a baffle around a rear rim of the skirt.
An agent which comprises an antibody that recognizes an IL-6 receptor as an active ingredient for use in (i) treating myocardial infarction or (ii) suppressing left ventricular remodeling after myocardial infarction. (i) treating myocardial infarction or (ii) suppressing left ventricular remodeling after myocardial infarction.
A screw load testing device comprising a housing configured to arrange a screw and a mating element that interacts with a threaded portion of the screw and is in particular formed as a threaded nut, said housing comprising a first housing member configured to interact at least indirectly with a portion that is in monolithic connection to the screw, further comprising a second housing member configured to interact with the mating element, wherein the two housing members (14, 62) are arranged movably with respect to one another at least in the direction of a longitudinal axis, said screw load testing device further comprising a measuring device for detecting an axial force F acting on the screw and/or for detecting a torque M acting on the screw, wherein the two housing members (14, 62) are movable from a first position at least into a second position by means of a clamping device, in that in the first position a first distance in the direction of the longitudinal axis between two contact surfaces (19, 61) configured to interact with the screw and the mating element, respectively, is smaller than a second distance between the two contact surfaces (19, 61) in the second position, characterized in that a size change member comprises a plurality of through-holes having different diameters is provided as mating element for the portion in monolithic connection to the screw, and in that the size change member can be arranged in a rotationally fixed manner in axial contact with the first housing member. wherein the two housing members (14, 62) are movable from a first position at least into a second position by means of a clamping device, in that in the first position a first distance in the direction of the longitudinal axis between two contact surfaces (19, 61) configured to interact with the screw and the mating element, respectively, is smaller than a second distance between the two contact surfaces (19, 61) in the second position, characterized in that a size change member comprises a plurality of through-holes having different diameters is provided as mating element for the portion in monolithic connection to the screw, and in that the size change member can be arranged in a rotationally fixed manner in axial contact with the first housing member.
A system comprising: a threshold detector circuit; a first switching circuit for enabling access to a back-up power source, the first switching circuit comprising at least a first transistor; wherein the threshold detector circuit is configured to cause the first switching circuit to enable access to the back-up power source responsive to a voltage provided by a primary power source dropping below a predetermined threshold; characterized in that it further comprises an inverting switch coupled between the first switching circuit and the threshold detector circuit wherein the inverting switch comprises a first and a second transistor connected in series and wherein the base of the second transistor is coupled to a capacitor to delay turning on of the second transistor when the input of the inverting switch transitions from a low to a high state. a threshold detector circuit; a first switching circuit for enabling access to a back-up power source, the first switching circuit comprising at least a first transistor; wherein the threshold detector circuit is configured to cause the first switching circuit to enable access to the back-up power source responsive to a voltage provided by a primary power source dropping below a predetermined threshold; characterized in that it further comprises an inverting switch coupled between the first switching circuit and the threshold detector circuit wherein the inverting switch comprises a first and a second transistor connected in series and wherein the base of the second transistor is coupled to a capacitor to delay turning on of the second transistor when the input of the inverting switch transitions from a low to a high state.
An intravascular device, comprising: an elongated shaft extending in an axial direction and being formed of a plurality of filaments, wherein the filaments of the elongated shaft are arranged in a single file continuum around an axis of the elongated shaft in a loop, and extend in a direction parallel to the axis of the elongated shaft; an expandable braided arrangement of the plurality of filaments, the braided arrangement having a proximal end, a distal end, and an intermediate region therebetween; an endpiece located proximate to an intersection of the elongated shaft and the braided arrangement, the endpiece being configured to orient the plurality of filaments in the single file continuum, and wherein at a junction of the expandable braided arrangement and the endpiece, the plurality of filaments initially extend in a parallel, non-crossing manner, and as the plurality of filaments extend towards the intermediate region of the braided arrangement the plurality of filaments cross each other. an elongated shaft extending in an axial direction and being formed of a plurality of filaments, wherein the filaments of the elongated shaft are arranged in a single file continuum around an axis of the elongated shaft in a loop, and extend in a direction parallel to the axis of the elongated shaft; an expandable braided arrangement of the plurality of filaments, the braided arrangement having a proximal end, a distal end, and an intermediate region therebetween; an endpiece located proximate to an intersection of the elongated shaft and the braided arrangement, the endpiece being configured to orient the plurality of filaments in the single file continuum, and wherein at a junction of the expandable braided arrangement and the endpiece, the plurality of filaments initially extend in a parallel, non-crossing manner, and as the plurality of filaments extend towards the intermediate region of the braided arrangement the plurality of filaments cross each other.
An apparatus for fabricating foamed and sintered implant material, the apparatus for forming a newly processed layer on implant material made of molded dense substrate by applying a heat source on the implant material, the apparatus comprising: a heat-source applying unit configured to burn a bone arranged adjacent to the implant material by the heat source, melt a surface-modification area to be subjected to a surface modification on the implant material by applying the heat source to the surface-modification area, and foam and sinter the implant material in the surface-modification area in a gas atmosphere generated by burning the bone; a processing-condition setting unit configured to set a processing condition for the implant material when performing the above-mentioned surface modification process on the implant material; and a control unit configured to control an application of the heat source when performing said surface modification process on the implant material based on the processing condition set by the processing-condition setting unit. a heat-source applying unit configured to burn a bone arranged adjacent to the implant material by the heat source, melt a surface-modification area to be subjected to a surface modification on the implant material by applying the heat source to the surface-modification area, and foam and sinter the implant material in the surface-modification area in a gas atmosphere generated by burning the bone; a processing-condition setting unit configured to set a processing condition for the implant material when performing the above-mentioned surface modification process on the implant material; and a control unit configured to control an application of the heat source when performing said surface modification process on the implant material based on the processing condition set by the processing-condition setting unit.
A lawn mower for mowing lawns on a ground having a drive shaft adapted to transmit a rotational driving force of a prime mover, a blade (16; 116), a connecting member adapted to connect the blade with the drive shaft such that the drive shaft rotates the connecting member and the blade (16; 116) in a rotating direction, and a fan which includes a fan blade (82d1) integrally formed at the connecting member and an opening (82d2) defined in the connecting member, characterized in that the fan blade (82d1) is formed so that the base thereof is connected to three sides out of four sides of the opening (82d2), wherein the three sides of the opening (82d2) include a first side (82d21) positioned on a rear side in the rotating direction of the blade and two second sides (82d22, 82d23) continued from the first side (82d21).
Dynamic orthosis of the drop foot, comprising a flat, vertical bar anchored to a collar adapted to be attached to a patient's leg and whose lower end is integral to a rolling bearing extended in a vertical plane in front of a malleolus of said leg when being used, with its horizontal axis passing through the malleolus and forming at the same time an articulation with an arm extended in a plane parallel to that of the bar and oscillating in both directions, said arm being connected to a bracket able to lift the drop foot from below, characterized in that the device intended to operate the drop foot's lifting mechanism during walking comprises a magnetic spring whose lifting force Fs is obtained by a plurality of pairs of magnets being equal to each other and having the same juxtaposed polarity.