mhurhangee/ep-ind-claims huggingface dataset:
An antibody-drug conjugate wherein an antitumor compound represented by the following formula is conjugated to an anti-HER3 antibody by a thioether bond which is formed at a disulfide bond moiety present in a hinge part of the anti-HER3 antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH- (CH 2)n 1 -L a -(CH 2)n 2 -C(=O)- or -L 1 -L 2 -L P - wherein, the anti-HER3 antibody is connected to the terminal of L 1, the antitumor compound is connected to the carbonyl group of -(CH 2)n 2 -C(=O)- moiety or the C terminal of L P, with the nitrogen atom of the amino group at position 1 as a connecting position, wherein, n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, L 1 represents -(Succinimid-3-yl-N)-(CH 2)n 3 -C(=O)-, wherein n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents a tetrapeptide residue -GGFG- or pentapeptide residue -DGGFG-, L a represents -O- or a single bond, -(Succinimid-3-yl-N)- has a structure represented by the following formula: which is connected to the anti-HER3 antibody at position 3 thereof and is connected to a methylene group in the linker structure containing this structure on the nitrogen atom at position 1. wherein, the anti-HER3 antibody is connected to the terminal of L 1, the antitumor compound is connected to the carbonyl group of -(CH 2)n 2 -C(=O)- moiety or the C terminal of L P, with the nitrogen atom of the amino group at position 1 as a connecting position, wherein, n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, L 1 represents -(Succinimid-3-yl-N)-(CH 2)n 3 -C(=O)-, wherein n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents a tetrapeptide residue -GGFG- or pentapeptide residue -DGGFG-, L a represents -O- or a single bond,
Container handling device, in particular a closing machine for closing cans or similar containers with a closure lid along a container handling section running in a handling direction, comprising at least one first transporter, a rotor located downstream of the first transporter in the handling direction along the container handling section, at the circumference of which are formed several container closing stations for closing the containers with a closure lid provided in each case from a closure lid delivery conveyor, wherein the rotor is arranged such as to circulate about a central column which extends along a vertical machine axis and is fixed in position, wherein the container closing stations rotating about the central column comprise in each case at least one punch device, arranged such as to move downwards and upwards at the rotor, as well as a container carrier provided beneath the punch device, which is provided such as to move in rotation and rising upwards on a carrier rim, said rim being driven by means of a motor such as to circulate about the central column beneath the rotor, characterised in that the first transporter is configured as a linear conveyor, by means of which the containers, not yet closed and standing upright with their container bases (2.1) on a transport plane, can be conveyed in the handling direction, and are transferred to a corresponding container closing station of the rotor being driven by a motor such as to circulate about the central column, and that arranged between at least two adjacent container closing stations is a transfer thrust element, which encloses the respective container carrier around at least part of its circumference and is provided such as to rotate together with the container closing station, and wherein the transfer thrust element forms on its upper side a transfer thrust plane (ÜE), for the planar thrust transfer of the upright container from the transport plane onto the transfer thrust plane (ÜE) spanned by the transfer thrust element, inasmuch as the transfer thrust plane (ÜE) together with the transport plane spans a common plane.
A management device that is configured to manage a predetermined work to be performed by an operator using a predetermined work unit for multiple board processing machines which perform a predetermined process on a circuit board, comprising: a work information acquisition means configured to acquire at least a work target from the multiple board processing machines and a work timing by which time the predetermined work is required for the work target, as work information, the work information acquisition means being configured to acquire multiple pieces of the work information; a position acquisition means configured to acquire a current position of the work unit; a work sequence determination means configured to determine a work sequence for multiple work targets based on the current position of the work unit acquired by the position acquisition means, within a range where the predetermined work can be performed before elapse of the work timings respectively corresponding to the multiple work targets relating to the multiple acquired pieces of the work information; and a work instruction means comprising a display or a portable information terminal and being configured to instruct the operator to perform the predetermined work based on the determined work sequence by notifying the operator on the display or the portable information terminal. a work information acquisition means configured to acquire at least a work target from the multiple board processing machines and a work timing by which time the predetermined work is required for the work target, as work information, the work information acquisition means being configured to acquire multiple pieces of the work information; a position acquisition means configured to acquire a current position of the work unit; a work sequence determination means configured to determine a work sequence for multiple work targets based on the current position of the work unit acquired by the position acquisition means, within a range where the predetermined work can be performed before elapse of the work timings respectively corresponding to the multiple work targets relating to the multiple acquired pieces of the work information; and a work instruction means comprising a display or a portable information terminal and being configured to instruct the operator to perform the predetermined work based on the determined work sequence by notifying the operator on the display or the portable information terminal.
A method of simulating a design circuitry comprising: receiving descriptions of a design circuitry including design registers to receive register input signals; and generating additional descriptions through at least one computer program including descriptions of additional registers configured to receive snapshots of the content from the design registers, wherein the additional registers provide initial condition signals for use in a simulation of at least a portion of the design circuitry; the method being characterized in that the design circuitry further includes a design memory configured to receive memory input signals, and the additional descriptions include descriptions of a replicated memory configured to receive at least some of the memory input signals after they are delayed by a delay circuitry, and wherein the replicated memory provides memory initial condition signals for use in the simulation; wherein the additional descriptions include descriptions of a counter configured to count clock cycles of a clock signal that clocks at least one of the additional registers and the additional description further comprises an enabling circuitry configured to enable writing to at least some of the additional registers after a particular number of clock cycles; wherein the additional descriptions include descriptions of a counter read circuitry configured to read contents of the counter responsive to reception of a trigger signal, and a control circuitry configured to cause the contents of the replicated memory to change in response to the reception of the trigger signal and a value of the count. receiving descriptions of a design circuitry including design registers to receive register input signals; and generating additional descriptions through at least one computer program including descriptions of additional registers configured to receive snapshots of the content from the design registers, wherein the additional registers provide initial condition signals for use in a simulation of at least a portion of the design circuitry; the method being characterized in that the design circuitry further includes a design memory configured to receive memory input signals, and the additional descriptions include descriptions of a replicated memory configured to receive at least some of the memory input signals after they are delayed by a delay circuitry, and wherein the replicated memory provides memory initial condition signals for use in the simulation; wherein the additional descriptions include descriptions of a counter configured to count clock cycles of a clock signal that clocks at least one of the additional registers and the additional description further comprises an enabling circuitry configured to enable writing to at least some of the additional registers after a particular number of clock cycles; wherein the additional descriptions include descriptions of a counter read circuitry configured to read contents of the counter responsive to reception of a trigger signal, and a control circuitry configured to cause the contents of the replicated memory to change in response to the reception of the trigger signal and a value of the count.
Active induction thermography method, wherein a multiplicity of images of an object to be inspected are respectively acquired by means of a camera for a multiplicity of acquisition directions, wherein the following steps are carried out for each individual acquisition direction: derivation of a complex-value Fourier-transformed image from the images; determination of an average phase value from the Fourier-transformed image; wherein a phase-corrected Fourier-transformed image is derived from the average phase value and the Fourier-transformed image for each acquisition direction, so that the phase-corrected Fourier-transformed images then have an essentially equal average phase value, and wherein a combined Fourier-transformed image is derived from the phase-corrected Fourier-transformed images. derivation of a complex-value Fourier-transformed image from the images; determination of an average phase value from the Fourier-transformed image; wherein a phase-corrected Fourier-transformed image is derived from the average phase value and the Fourier-transformed image for each acquisition direction, so that the phase-corrected Fourier-transformed images then have an essentially equal average phase value, and wherein a combined Fourier-transformed image is derived from the phase-corrected Fourier-transformed images.
System for correcting torque oscillations generated in a transmission of a hybrid-propulsion motor vehicle comprising a combustion engine, at least one electric machine and a mechanical transmission connected to said combustion engine, to said electric machine and to the wheels (28a, 28b) of the vehicle, said system comprising: - a supervision module able to select, out of the combustion engine and the electric machine (12, 14), the actuator capable of providing the torque correction, and - a torque oscillation correction module able to deliver a corrected torque setpoint (C corr) as a function of the rotational speed (ω) observed at the output of the selected actuator, characterized in that the torque oscillation correction module is integrated directly into each of the actuators (12, 14), and comprises an oscillation detection module comprising two low-pass filters (F1, F2) in series in order to isolate frequencies due to an oscillation generated by a jerk and to invert the phase of the signal. - a supervision module able to select, out of the combustion engine and the electric machine (12, 14), the actuator capable of providing the torque correction, and - a torque oscillation correction module able to deliver a corrected torque setpoint (C corr) as a function of the rotational speed (ω) observed at the output of the selected actuator,
Passenger conveyor comprising a plurality of treads interconnected to form an endless tread band, the passenger conveyor comprising a chain and sprocket drive system including at least two drive sprockets (24a, 24b), each drive sprocket (24a, 24b) drivingly coupled to a respective drive chain (20a, 20b), each drive sprocket (24a, 24b) having a predetermined number of drive sprocket teeth (38a, 38b) positioned at a predetermined drive sprocket teeth pitch (αa, αb) with respect to each other, characterized in that the drive sprockets (24a, 24b) are configured to rotate with the same angular velocity, but at a predetermined phase difference (β) with respect to each other.
A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains potassium hydrogen carbonate and at least one selected from the group consisting of a ropinirole free form obtainable as a reaction product between the pharmaceutically acceptable acid addition salt of ropinirol and potassium hydrogen carbonate and the pharmaceutically acceptable acid addition salt of ropinirol, which remained unreacted. a backing layer; and an adhesive layer, wherein the adhesive layer contains potassium hydrogen carbonate and at least one selected from the group consisting of a ropinirole free form obtainable as a reaction product between the pharmaceutically acceptable acid addition salt of ropinirol and potassium hydrogen carbonate and the pharmaceutically acceptable acid addition salt of ropinirol, which remained unreacted.
A method for open-loop frequency tracking of the carrier component of a reference positioning signal received at a positioning-unit device, said reference positioning signal being transmitted by at least one reference transmitter, said positioning-unit device comprising a receiver, a common oscillator and a frequency steerable clock connected to a transmitter, said common oscillator being common to said receiver and said frequency steerable clock, said method comprising the steps of: receiving said reference positioning signal at said receiver; measuring a frequency offset of the carrier component of the received reference positioning signal relative to said common oscillator; referencing said frequency steerable clock to said common oscillator; continuously adjusting said frequency steerable clock by an amount derived from the measured frequency offset; and generating a unique positioning signal at said transmitter, wherein the frequency of the carrier component of said unique positioning signal is aligned with said frequency steerable clock; such that said frequency steerable clock can be adjusted by applying an additional frequency offset for a predetermined time period to time slew said unique positioning signal. receiving said reference positioning signal at said receiver; measuring a frequency offset of the carrier component of the received reference positioning signal relative to said common oscillator; referencing said frequency steerable clock to said common oscillator; continuously adjusting said frequency steerable clock by an amount derived from the measured frequency offset; and generating a unique positioning signal at said transmitter, wherein the frequency of the carrier component of said unique positioning signal is aligned with said frequency steerable clock; such that said frequency steerable clock can be adjusted by applying an additional frequency offset for a predetermined time period to time slew said unique positioning signal.
A delivery device comprising a container containing a dose of powder, a chamber adapted to receive the container, at least one gas inlet by which gas may enter the chamber, and at least one gas outlet by which gas and entrained powder may exit the chamber for inhalation, the delivery device having a pre-use configuration in which the container is accommodated, at least partially, within a storage enclosure in a wall of the chamber, the delivery device having a deployment member adapted to put the delivery device in an operative configuration by displacing the container from the storage enclosure into the chamber, such that the container is movable within the chamber, in use, the deployment member being adapted to at least partially occupy the storage enclosure in the operative configuration; characterised in that the deployment member is retained in a pre-use position by retaining formations (36,74), which are adapted to maintain the deployment member in the pre-use position during normal handling, wherein the retaining formations (36,74) have the form of a cooperating projection and recess.
An epoxy resin composition, comprising: a first aromatic epoxy resin represented by formula: wherein a-h are independently hydrogen or methyl; a second aromatic epoxy resin represented by the following formula: an alicyclic epoxy resin selected from the group consisting of and and an amino compound selected from the group consisting of 4,4'-methylenedianiline, 4,4'-ethylenedianiline, 4,4'-bis(4-aminophenoxy)biphenyl (BAPB) and 1,4-bis(4-aminophenoxy)benzene, wherein the ratio between the epoxy groups of the first aromatic epoxy resin, the second aromatic epoxy resin and the alicyclic epoxy resin and the amino groups of the amino compound ranges from 1:1 to 2:1. a first aromatic epoxy resin represented by formula: wherein a-h are independently hydrogen or methyl; a second aromatic epoxy resin represented by the following formula: an alicyclic epoxy resin selected from the group consisting of and and an amino compound selected from the group consisting of 4,4'-methylenedianiline, 4,4'-ethylenedianiline, 4,4'-bis(4-aminophenoxy)biphenyl (BAPB) and 1,4-bis(4-aminophenoxy)benzene, wherein the ratio between the epoxy groups of the first aromatic epoxy resin, the second aromatic epoxy resin and the alicyclic epoxy resin and the amino groups of the amino compound ranges from 1:1 to 2:1.
A method for treating tobacco material, the method comprising: o fermenting the tobacco material to obtain treated tobacco material, including: ▪ incubating the tobacco material under anaerobic conditions; ▪ applying a pressure to the tobacco material comprised between 1000 kilograms per square meter and 4000 kilograms per square meter; ▪ keeping the moisture content of the tobacco material comprised between 25 percent in weight and 40 percent in weight of the total weight of the tobacco material; o wherein the fermenting lasts at least two months. o fermenting the tobacco material to obtain treated tobacco material, including: ▪ incubating the tobacco material under anaerobic conditions; ▪ applying a pressure to the tobacco material comprised between 1000 kilograms per square meter and 4000 kilograms per square meter; ▪ keeping the moisture content of the tobacco material comprised between 25 percent in weight and 40 percent in weight of the total weight of the tobacco material; ▪ incubating the tobacco material under anaerobic conditions; ▪ applying a pressure to the tobacco material comprised between 1000 kilograms per square meter and 4000 kilograms per square meter; ▪ keeping the moisture content of the tobacco material comprised between 25 percent in weight and 40 percent in weight of the total weight of the tobacco material; o wherein the fermenting lasts at least two months.
A dilution hole assembly comprising: a first wall extending continuously about a centerline and defining a radially inward hole; at least one outer vane projecting radially inward from the first wall for swirling at least a portion of air flowing through the hole; and a second wall extending continuously about the centerline and spaced radially inward from the first wall, wherein a first portion of the hole contains the at least one outer vane with each outer vane extending radially between and engaged to the first and second walls (118, 122); characterised in that the dilution hole assembly further comprises: at least one inner vane projecting radially inward from the second wall, and spaced circumferentially about the centerline. a first wall extending continuously about a centerline and defining a radially inward hole; at least one outer vane projecting radially inward from the first wall for swirling at least a portion of air flowing through the hole; and a second wall extending continuously about the centerline and spaced radially inward from the first wall, wherein a first portion of the hole contains the at least one outer vane with each outer vane extending radially between and engaged to the first and second walls (118, 122); characterised in that the dilution hole assembly further comprises: at least one inner vane projecting radially inward from the second wall, and spaced circumferentially about the centerline. at least one inner vane projecting radially inward from the second wall, and spaced circumferentially about the centerline.
A process for the generation of electricity, which comprises extracting a warm saline stream from a geothermal formation, and: (a) converting thermal energy present in said stream into electricity; and (b) converting latent osmotic energy present in said stream into electricity by passage through an osmotic power unit in which said stream is passed over one side of a semi-permeable membrane which permits the passage of water but not the passage of salts, an aqueous stream of lower salinity than said stream being passed over the other side of said membrane (a) converting thermal energy present in said stream into electricity; and (b) converting latent osmotic energy present in said stream into electricity by passage through an osmotic power unit in which said stream is passed over one side of a semi-permeable membrane which permits the passage of water but not the passage of salts, an aqueous stream of lower salinity than said stream being passed over the other side of said membrane
A microwave heating device mountable to an electric device, comprising: a commercial power supply; an AC/DC converter which outputs a plurality of DC voltages according to power supplied from the commercial power supply; a controller which receives power from the AC/DC converter and totally controls the electric device; a microwave processing device; and a plurality of loads, wherein the loads form a group of electric components (14, 15, 16) in the electric device; the microwave heating device being characterized in that: the microwave processing device uses a compound semiconductor which receives a plurality of outputs of the AC/DC converter and outputs a microwave; and the plurality of loads are connected between, of the DC voltages output from the AC/DC converter, a predetermined Vd voltage and ground through a plurality of contact portions; wherein the controller controls power supply to the loads, and controls on/off of the contact portions to drive the loads by the Vd voltage regardless of the voltage of the commercial power supply. a commercial power supply; an AC/DC converter which outputs a plurality of DC voltages according to power supplied from the commercial power supply; a controller which receives power from the AC/DC converter and totally controls the electric device; a microwave processing device; and a plurality of loads, the microwave processing device uses a compound semiconductor which receives a plurality of outputs of the AC/DC converter and outputs a microwave; and the plurality of loads are connected between, of the DC voltages output from the AC/DC converter, a predetermined Vd voltage and ground through a plurality of contact portions;