A cleaning composition comprising: (a) one or more surface active proteins selected from the group consisting of ranaspumins, latherins, and mixtures thereof, preferably ranaspumins; (i) wherein the ranaspumins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of at least one reference sequence selected from the group consisting of: Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1), Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2), Leptodactylus fuscus Lf-Rsn1 (SEQ ID NO: 3), and Bufo gargarizans Bg-Rsn (SEQ ID NO: 4), preferably Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1) and Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2); and (ii) wherein the latherins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of Equus caballus latherin (SEQ ID NO: 10); and (b) a surfactant system, wherein the surfactant system comprises one or more anionic surfactants and one or more co-surfactants, wherein the co-surfactants are selected from the group consisting of amphoteric surfactant, zwitterionic surfactant, and mixtures thereof, and wherein the weight ratio of the anionic surfactants to the co-surfactants is less than 9:1, more preferably from 5:1 to 1:1, more preferably from 4:1 to 2:1. (a) one or more surface active proteins selected from the group consisting of ranaspumins, latherins, and mixtures thereof, preferably ranaspumins; (i) wherein the ranaspumins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of at least one reference sequence selected from the group consisting of: Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1), Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2), Leptodactylus fuscus Lf-Rsn1 (SEQ ID NO: 3), and Bufo gargarizans Bg-Rsn (SEQ ID NO: 4), preferably Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1) and Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2); and (ii) wherein the latherins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of Equus caballus latherin (SEQ ID NO: 10); and (i) wherein the ranaspumins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of at least one reference sequence selected from the group consisting of: Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1), Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2), Leptodactylus fuscus Lf-Rsn1 (SEQ ID NO: 3), and Bufo gargarizans Bg-Rsn (SEQ ID NO: 4), preferably Engystomops pustulosus Ep-Rsn2 (SEQ ID NO: 1) and Leptodactylus vastus Lv-Rsnl (SEQ ID NO: 2); and (ii) wherein the latherins have at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 98%, or even 100% amino acid identity as calculated over the entire length of the sequence aligned against the entire length of Equus caballus latherin (SEQ ID NO: 10); and (b) a surfactant system, wherein the surfactant system comprises one or more anionic surfactants and one or more co-surfactants, wherein the co-surfactants are selected from the group consisting of amphoteric surfactant, zwitterionic surfactant, and mixtures thereof, and wherein the weight ratio of the anionic surfactants to the co-surfactants is less than 9:1, more preferably from 5:1 to 1:1, more preferably from 4:1 to 2:1.