Method for determining the amount of the specific analyte of a sample which may show interferences by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents, comprising the steps: a) generating multiple calibration curves for multiple wavelengths for the specific analyte of a sample to be determined, wherein - calibration curve 1 is recorded at wavelength land reaction time 1 optimized for samples showing no interferences, - calibration curve 2 is recorded at wavelength 2 and reaction time 2 optimized for samples showing hemolytic interferences, - calibration curve 3 is recorded at wavelength 3 and reaction time 3 optimized for samples showing icteric interferences, - calibration curve 4 is recorded at wavelength 4 and reaction time 4 for samples showing lipemic interferences, and depositing these predetermined measurement results in a data management system of the instrument platform, b) performing an interference test, simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample to be determined and comparing the amount of each interfering substances to predetermined cut-off values, c) measuring the optical signal for the specific analyte of a sample to be determined in the reaction mixture at multiple wavelengths and time points, d) selecting the corresponding calibration curve of step a) depending on the interfering substances, e) quantifying the amount of the specific analyte of a sample to be determined by comparison with the selected calibration curve of step d) for the chosen wavelengths. a) generating multiple calibration curves for multiple wavelengths for the specific analyte of a sample to be determined, wherein - calibration curve 1 is recorded at wavelength land reaction time 1 optimized for samples showing no interferences, - calibration curve 2 is recorded at wavelength 2 and reaction time 2 optimized for samples showing hemolytic interferences, - calibration curve 3 is recorded at wavelength 3 and reaction time 3 optimized for samples showing icteric interferences, - calibration curve 4 is recorded at wavelength 4 and reaction time 4 for samples showing lipemic interferences, and depositing these predetermined measurement results in a data management system of the instrument platform, - calibration curve 1 is recorded at wavelength land reaction time 1 optimized for samples showing no interferences, - calibration curve 2 is recorded at wavelength 2 and reaction time 2 optimized for samples showing hemolytic interferences, - calibration curve 3 is recorded at wavelength 3 and reaction time 3 optimized for samples showing icteric interferences, - calibration curve 4 is recorded at wavelength 4 and reaction time 4 for samples showing lipemic interferences, b) performing an interference test, simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample to be determined and comparing the amount of each interfering substances to predetermined cut-off values, c) measuring the optical signal for the specific analyte of a sample to be determined in the reaction mixture at multiple wavelengths and time points, d) selecting the corresponding calibration curve of step a) depending on the interfering substances, e) quantifying the amount of the specific analyte of a sample to be determined by comparison with the selected calibration curve of step d) for the chosen wavelengths.