A system for the monitoring and the control of a subject's organ perfusion comprising: - optionally at least one therapeutic agent, - at least one first retrievable medical device, for the simultaneous or the separate perfusion and occlusion of the vessel of the organ inflow, comprising a body having a distal end, a proximal end, at least one lumen extending between the proximal end and the distal end, at least one opening which is in fluid communication with the lumen for delivering a fluid to said vessel and at least one expandable balloon coupled with the body of the device, - at least one second retrievable medical device for isolating and collecting the organ outflow, said device is provided with a distal end and a proximal end; said second medical device comprises a catheter suitable for deploying an expanding member; the proximal end of the expanding member is attached to the distal end of the catheter, - a fluid storage reservoir having at least one inlet and at least one outlet, said inlet is suitable to be connected to the proximal end of the second retrievable medical device and said outlet is suitable to be connected to the proximal end of the first retrievable medical device medical, - at least one pump (104,105) for withdrawing fluid from the organ and directing said fluid to the fluid storage reservoir through the inlet of said fluid storage reservoir, - at least one pump for withdrawing fluid from the fluid storage reservoir at a determined flow rate and directing said fluid to the organ inflow, - optionally, at least one marker for real time monitoring of the leak rate from the organ to the systemic blood circulation, - at least one marker detector positioned upstream of the inlet of the fluid storage reservoir, - at least one marker detector positioned in at least one vessel of the systemic blood circulation, - at least one volume sensor positionned in the fluid storage reservoir, - at least one pressure detector for measuring the fluid pressure inside the organ to be perfused, and - at least one interface for receiving and presenting output system data and for controlling and/or adjusting input system data, wherein the output system data comprises the data collected by the pressure detector and the marker detectors (104, 105); and the input system data comprises the fluid flow rate to be withdrawn from the fluid storage reservoir which is directed to the organ inflow. - optionally at least one therapeutic agent, - at least one first retrievable medical device, for the simultaneous or the separate perfusion and occlusion of the vessel of the organ inflow, comprising a body having a distal end, a proximal end, at least one lumen extending between the proximal end and the distal end, at least one opening which is in fluid communication with the lumen for delivering a fluid to said vessel and at least one expandable balloon coupled with the body of the device, - at least one second retrievable medical device for isolating and collecting the organ outflow, said device is provided with a distal end and a proximal end; said second medical device comprises a catheter suitable for deploying an expanding member; the proximal end of the expanding member is attached to the distal end of the catheter, - a fluid storage reservoir having at least one inlet and at least one outlet, said inlet is suitable to be connected to the proximal end of the second retrievable medical device and said outlet is suitable to be connected to the proximal end of the first retrievable medical device medical, - at least one pump (104,105) for withdrawing fluid from the organ and directing said fluid to the fluid storage reservoir through the inlet of said fluid storage reservoir, - at least one pump for withdrawing fluid from the fluid storage reservoir at a determined flow rate and directing said fluid to the organ inflow, - optionally, at least one marker for real time monitoring of the leak rate from the organ to the systemic blood circulation, - at least one marker detector positioned upstream of the inlet of the fluid storage reservoir, - at least one marker detector positioned in at least one vessel of the systemic blood circulation, - at least one volume sensor positionned in the fluid storage reservoir, - at least one pressure detector for measuring the fluid pressure inside the organ to be perfused, and - at least one interface for receiving and presenting output system data and for controlling and/or adjusting input system data, wherein the output system data comprises the data collected by the pressure detector and the marker detectors (104, 105); and the input system data comprises the fluid flow rate to be withdrawn from the fluid storage reservoir which is directed to the organ inflow.