mhurhangee/ep-ind-claims huggingface dataset:
A method for identifying a biomarker indicative of a reduced response to a drug in a patient comprising the steps of: a) heating either i) a sample from a patient having a reduced response to the drug or ii) a sample from a patient responsive to the drug; b) separating soluble from insoluble protein of i) or ii); and c) analysing either or both the soluble and insoluble fractions of step b) and either comparing with the corresponding fraction obtained from heating and separating a sample from a patient responsive to the drug when i) is heated and separated in steps a) and b), or comparing with the corresponding fraction obtained from heating and separating a sample from a patient having a reduced response to the drug when ii) is heated and separated in steps a) and b), to identify at least one protein which has a different melting temperature in the sample from the reduced drug response sample, compared to the sample from drug responsive patient, wherein the target protein for the drug is excluded from identification. a) heating either i) a sample from a patient having a reduced response to the drug or ii) a sample from a patient responsive to the drug; b) separating soluble from insoluble protein of i) or ii); and c) analysing either or both the soluble and insoluble fractions of step b) and either comparing with the corresponding fraction obtained from heating and separating a sample from a patient responsive to the drug when i) is heated and separated in steps a) and b), or comparing with the corresponding fraction obtained from heating and separating a sample from a patient having a reduced response to the drug when ii) is heated and separated in steps a) and b),
A thermosetting binder composition containing water and a water-soluble oligomeric ester - of at least one saccharide selected from reducing sugars, non-reducing sugars and hydrogenated sugars, the hydrogenated sugars being selected from the group consisting of erythritol, arabitol, xylitol, sorbitol, mannitol, iditol, maltitol, isomaltitol, lactitol, cellobitol, palatinitol, maltotritol and hydrogenation products of hydrolyzates of starch or of lignocellulose materials, and - of at least one polycarboxylic acid, the binder composition having a dry matter content of between 40% and 80% by weight, the water-soluble oligomeric ester representing at least 80% by weight, preferably at least 90% by weight, of the dry matter content of the thermosetting binder composition, and the thermosetting binder composition containing less than 10% by weight, preferably less than 5% by weight, with respect to its dry matter content, of free sorbitol. - of at least one saccharide selected from reducing sugars, non-reducing sugars and hydrogenated sugars, the hydrogenated sugars being selected from the group consisting of erythritol, arabitol, xylitol, sorbitol, mannitol, iditol, maltitol, isomaltitol, lactitol, cellobitol, palatinitol, maltotritol and hydrogenation products of hydrolyzates of starch or of lignocellulose materials, and - of at least one polycarboxylic acid,
A fluid dispenser comprising: a cover shroud comprising a shroud frame and a flexible cover sheet; the shroud frame comprising a rectangular peripheral rear frame member including a top frame member, a left side frame member, a bottom frame member and a right side frame member, the shroud frame further including a) at least a left side wire frame and a right side wire frame wherein the left side wire frame and the right side wire frame are connected to the peripheral rear frame member, and a front window is formed in between forwardmost portions of the left side wire frame and the right side wire frame, or b) a left side wire frame, a right side wire frame, a top wire frame and a bottom wire frame, and a front window is formed in between forward most portions of the left side wire frame, the right side wire frame, the top wire frame and the bottom wire frame; the cover sheet stretched over the shroud frame to span the front window and to define an internal cavity within the cover sheet, the dispenser carries a reservoir containing a fluid to be dispensed, the reservoir received within the internal cavity. a cover shroud comprising a shroud frame and a flexible cover sheet; the shroud frame comprising a rectangular peripheral rear frame member including a top frame member, a left side frame member, a bottom frame member and a right side frame member, the shroud frame further including a) at least a left side wire frame and a right side wire frame wherein the left side wire frame and the right side wire frame are connected to the peripheral rear frame member, and a front window is formed in between forwardmost portions of the left side wire frame and the right side wire frame, or b) a left side wire frame, a right side wire frame, a top wire frame and a bottom wire frame, and a front window is formed in between forward most portions of the left side wire frame, the right side wire frame, the top wire frame and the bottom wire frame; a) at least a left side wire frame and a right side wire frame wherein the left side wire frame and the right side wire frame are connected to the peripheral rear frame member, and a front window is formed in between forwardmost portions of the left side wire frame and the right side wire frame, or b) a left side wire frame, a right side wire frame, a top wire frame and a bottom wire frame, and a front window is formed in between forward most portions of the left side wire frame, the right side wire frame, the top wire frame and the bottom wire frame; the cover sheet stretched over the shroud frame to span the front window and to define an internal cavity within the cover sheet, the dispenser carries a reservoir containing a fluid to be dispensed, the reservoir received within the internal cavity.
A system comprising: a flexible cannula configured to deliver a medical device to a target site within a patient; and an implant tool configured to position the cannula within the patient, the implant tool comprising: a housing configured to be held by a user; a needle coupled to the housing and configured to be inserted into tissue of a patient, wherein the needle is configured to fit within the cannula, wherein a piercing tip of the needle extends past the cannula when the needle is fit within the cannula and the cannula is in a first position relative to the needle; and characterized by a release mechanism (54, 74, 89) configured to be moved by a finger or thumb of the user to apply a force against the cannula to move the cannula toward a distal end of the needle when the needle is fit within the cannula and the cannula is in the first position, wherein the release mechanism is configured to apply the force against the cannula in a direction away from the housing, such that the force moves the cannula away from the housing, and the needle may then be removed from the cannula by holding onto the housing. a flexible cannula configured to deliver a medical device to a target site within a patient; and an implant tool configured to position the cannula within the patient, the implant tool comprising: a housing configured to be held by a user; a needle coupled to the housing and configured to be inserted into tissue of a patient, wherein the needle is configured to fit within the cannula, wherein a piercing tip of the needle extends past the cannula when the needle is fit within the cannula and the cannula is in a first position relative to the needle; and characterized by a release mechanism (54, 74, 89) configured to be moved by a finger or thumb of the user to apply a force against the cannula to move the cannula toward a distal end of the needle when the needle is fit within the cannula and the cannula is in the first position, wherein the release mechanism is configured to apply the force against the cannula in a direction away from the housing, such that the force moves the cannula away from the housing, and the needle may then be removed from the cannula by holding onto the housing. a housing configured to be held by a user; a needle coupled to the housing and configured to be inserted into tissue of a patient, wherein the needle is configured to fit within the cannula, wherein a piercing tip of the needle extends past the cannula when the needle is fit within the cannula and the cannula is in a first position relative to the needle; and characterized by a release mechanism (54, 74, 89) configured to be moved by a finger or thumb of the user to apply a force against the cannula to move the cannula toward a distal end of the needle when the needle is fit within the cannula and the cannula is in the first position, wherein the release mechanism is configured to apply the force against the cannula in a direction away from the housing, such that the force moves the cannula away from the housing, and the needle may then be removed from the cannula by holding onto the housing.
A RISC processor, comprising a physical register stack, an operating component connected to the physical register stack and a decoder connected to the operating component, the physical register stack comprises an emulation flag register for emulating and realizing flag bits of a flag register in a CISC processor, the operating component comprises a flag read-write module for reading and writing the values of the flag bits of the emulation flag register, characterized in that: the decoder identifies that the operation is in the working mode of emulating EFLAGS when the decoder decodes a newly added legal instruction, the operating component executes an operation process and obtains an execution result according to a RISC instruction of the newly added legal instruction, wherein the execution result obtained from the operation process includes data values and flag bits; and after the operation process, the emulation flag register further modifies the value of the flag bit of the corresponding emulation flag register according to flag bits of the execution result, but data values of the execution result are not stored. the decoder identifies that the operation is in the working mode of emulating EFLAGS when the decoder decodes a newly added legal instruction, the operating component executes an operation process and obtains an execution result according to a RISC instruction of the newly added legal instruction, wherein the execution result obtained from the operation process includes data values and flag bits; and after the operation process, the emulation flag register further modifies the value of the flag bit of the corresponding emulation flag register according to flag bits of the execution result, but data values of the execution result are not stored.
Railway traction vehicle with eight traction wheels (24,13), provided with two bogies (11a, 11b) each with a rubber wheel axle with two rubber wheels and a rail wheel axle with two steel rail wheels each bogie pivoting around a swing axle fixed to a supporting framework, whereby the swing axle is positioned asymmetrically on the connecting line between the rail wheel axle and the rubber wheel axle and whereby the ratio between the downward force on the rail wheel axle and the rubber wheel axle is actively controlled by increasing the downward force on the rubber wheel axle and by decreasing the downward force on the rail wheel axle or vice versa, whereby each bogie (11a, 11b) can be tilted around its swing axle by exerting an upward hydraulic, pneumatic or electric force on the bogie (11a, 11b) on the side of the rail wheel axle, or by exerting an upward hydraulic, pneumatic or electric force on the bogie (11a, 11b) on the side of the rubber wheel axle or on the rubber wheel axle itself, characterised in that the ratio of the downward force on the rubber wheel axle and on the rail wheel axle is dynamically controlled by an electronic control unit depending on the expected traction force needed while hauling a train or during a hauling start or stop phase and in that the traction for each of the eight wheels (24, 13) is separately controlled by an electronic control unit that independently determines the traction force of each wheel and matches it with the dynamic control of the ratio of the downward force on the rubber wheel axle and on the rail wheel axle of each bogie.
A vehicle service system comprising: - a calibration apparatus, which is designed to calibrate at least one ADAS sensor comprised in an advanced driver assistance system of a vehicle arranged in a vehicle service area, said calibration apparatus is designed to move on a resting plane adjacent to said vehicle service area and comprises at least one calibration device, which is designed to be detected by said ADAS sensor during the calibration of the ADAS sensor itself, said vehicle service system is characterised in that it comprises a position detection system comprising: - at least two optical apparatuses, which are arranged in the vehicle service area on opposite sides of said vehicle one with respect to the other, and are configured to capture first images containing images of the vehicle, said optical apparatuses have respective positioning targets which are orientated in order to be facing said calibration apparatus, - two cameras which are mounted on said calibration apparatus so as to be arranged in lateral positions, on opposite sides with respect to said calibration device; the two cameras are optically orientated towards said optical apparatuses to capture second images which contain said positioning targets of said optical apparatuses, - electronic processing means which are configured so as to determine a first position indicative of the position of said calibration apparatus and/or of the position of said calibration device with respect to said vehicle, based on said first images and said second images. - a calibration apparatus, which is designed to calibrate at least one ADAS sensor comprised in an advanced driver assistance system of a vehicle arranged in a vehicle service area, said calibration apparatus is designed to move on a resting plane adjacent to said vehicle service area and comprises at least one calibration device, which is designed to be detected by said ADAS sensor during the calibration of the ADAS sensor itself, - at least two optical apparatuses, which are arranged in the vehicle service area on opposite sides of said vehicle one with respect to the other, and are configured to capture first images containing images of the vehicle, said optical apparatuses have respective positioning targets which are orientated in order to be facing said calibration apparatus, - two cameras which are mounted on said calibration apparatus so as to be arranged in lateral positions, on opposite sides with respect to said calibration device; the two cameras are optically orientated towards said optical apparatuses to capture second images which contain said positioning targets of said optical apparatuses, - electronic processing means which are configured so as to determine a first position indicative of the position of said calibration apparatus and/or of the position of said calibration device with respect to said vehicle, based on said first images and said second images.
A computer implemented method for processing of microscopic images obtained by spatially modulated illumination microscopy to detect objects of interest with size smaller than the optical resolution limit of the microscopic system with which the microscopic images are obtained, said method comprising: - subjecting the microscopic image to a bandpass filtering to obtain a filtered image, wherein the bandpass filtering is such as to suppress the noise and any objects, including non-uniform background, which are larger than a few pixels; said method characterized in further comprising - processing the filtered image at a plurality of progressively decreasing threshold levels of image intensity, said processing comprising: - at each threshold level detecting the objects of interest using an object labelling algorithm; and - removing the objects detected at a given threshold level from the working image before proceeding to the next threshold level. - subjecting the microscopic image to a bandpass filtering to obtain a filtered image, wherein the bandpass filtering is such as to suppress the noise and any objects, including non-uniform background, which are larger than a few pixels; - processing the filtered image at a plurality of progressively decreasing threshold levels of image intensity, said processing comprising: - at each threshold level detecting the objects of interest using an object labelling algorithm; and - removing the objects detected at a given threshold level from the working image before proceeding to the next threshold level.
In a server system, a computer-implemented method of initiating a communication protocol involving a first and a second client device, the method comprising: 1) receiving from the first client device a request to initiate the protocol, the request comprising a geographical location of the first client device but lacking any identification of the second client device, a particular application in the first client device currently being active and on a foreground of a display screen of the first client device, 2) determining from plural client devices in communication with the server system their respective geographical locations and selecting one or more client devices (a) whose geographical location is within a predetermined distance to the first client, (b) who have indicated in a communication to the server system an availability for participation in the communication protocol, and (c) in each of which a particular application is currently active and on a foreground of a respective display screen of each of the plural client devices, 3) transmitting to the first client device indications of the one or more selected client devices, 4) receiving from the first client device a selection of one client device from the one or more selected client devices if the particular application in the first client device is still currently active and on the foreground, and 5) causing the communication protocol to be started involving the first and the second client devices. 1) receiving from the first client device a request to initiate the protocol, the request comprising a geographical location of the first client device but lacking any identification of the second client device, a particular application in the first client device currently being active and on a foreground of a display screen of the first client device, 2) determining from plural client devices in communication with the server system their respective geographical locations and selecting one or more client devices (a) whose geographical location is within a predetermined distance to the first client, (b) who have indicated in a communication to the server system an availability for participation in the communication protocol, and (c) in each of which a particular application is currently active and on a foreground of a respective display screen of each of the plural client devices, 3) transmitting to the first client device indications of the one or more selected client devices, 4) receiving from the first client device a selection of one client device from the one or more selected client devices if the particular application in the first client device is still currently active and on the foreground, and 5) causing the communication protocol to be started involving the first and the second client devices.
A system for optimizing a patient's Kegel exercises comprising: a user interface device comprising a display, the user interface configured to run an application comprising visual feedback features; and an intravaginal device comprising a plurality of MEMS accelerometers positioned along a length of the intravaginal device and configured to generate a signal in response to movement of the MEMS accelerometers; wherein the user interface device is wirelessly connected to the intravaginal device and is configured to analyze signals from the MEMS accelerometers using the application; wherein the application is configured to display a line on the display corresponding to a position of the MEMS accelerometers during performance of the pelvic floor exercise, wherein the line corresponds to a lift maneuver when the line rotates from right to left, and wherein the line corresponds to a bearing down movement and/or relaxation of pelvic floor muscles when the line rotates from left to right; wherein the application is configured to record and display on the display a history of scores resulting from pelvic floor exercise sessions performed by the patient using the intravaginal device, wherein the history of scores comprises highest score information and maximum lift duration, each of which is generated from data produced by the MEMS accelerometers; and wherein the system provides physiological feedback information to the patient using the visual feedback features to optimize the Kegel exercise. a user interface device comprising a display, the user interface configured to run an application comprising visual feedback features; and an intravaginal device comprising a plurality of MEMS accelerometers positioned along a length of the intravaginal device and configured to generate a signal in response to movement of the MEMS accelerometers; wherein the user interface device is wirelessly connected to the intravaginal device and is configured to analyze signals from the MEMS accelerometers using the application; wherein the application is configured to display a line on the display corresponding to a position of the MEMS accelerometers during performance of the pelvic floor exercise, wherein the line corresponds to a lift maneuver when the line rotates from right to left, and wherein the line corresponds to a bearing down movement and/or relaxation of pelvic floor muscles when the line rotates from left to right; wherein the application is configured to record and display on the display a history of scores resulting from pelvic floor exercise sessions performed by the patient using the intravaginal device, wherein the history of scores comprises highest score information and maximum lift duration, each of which is generated from data produced by the MEMS accelerometers; and wherein the system provides physiological feedback information to the patient using the visual feedback features to optimize the Kegel exercise.