mhurhangee/ep-ind-claims huggingface dataset:
An acellular pro-tolerogenic conditioned preparation comprising miRNA species and lacking components having an average molecular weight of more than about 10 kDa for use in preventing or limiting the rejection of transplanted cells or tissue or graft-versus-host disease in a subject by increasing a ratio of the level of regulatory T (Treg) cells to the level of pro-inflammatory T cells in a subject, wherein the pro-tolerogenic preparation has been obtained by a process comprising: (i) associating a low-immunogenic biocompatible polymer to a cytoplasmic membrane of a first leukocyte to obtain a first modified leukocyte, wherein the low-immunogenic biocompatible polymer is polyethylene glycol, 2-alkyloxazoline or hyperbranched polyglycerol; (ii) contacting the first modified leukocyte with a second leukocyte under conditions to allow a pro-tolerogenic allo-recognition to provide a conditioned preparation, wherein the first leukocyte is allogeneic to the second leukocyte; (iii) removing the first modified leukocyte, the second leukocyte and components having an average molecular weight of more than about 10 kDa from the conditioned preparation under conditions to inhibit RNA degradation to enrich the miRNA species in the conditioned preparation and to maintain the relative abundance of each of the miRNA species so as to obtain a composition comprising miRNAs species; and (iv) formulating the composition of step (iii), under conditions to inhibit RNA degradation and to maintain the relative abundance of each of the miRNA species, in the acellular pro-tolerogenic conditioned preparation for administration to a subject, wherein the administration of the pro-tolerogenic preparation increases the ratio in the subject. (i) associating a low-immunogenic biocompatible polymer to a cytoplasmic membrane of a first leukocyte to obtain a first modified leukocyte, wherein the low-immunogenic biocompatible polymer is polyethylene glycol, 2-alkyloxazoline or hyperbranched polyglycerol; (ii) contacting the first modified leukocyte with a second leukocyte under conditions to allow a pro-tolerogenic allo-recognition to provide a conditioned preparation, wherein the first leukocyte is allogeneic to the second leukocyte; (iii) removing the first modified leukocyte, the second leukocyte and components having an average molecular weight of more than about 10 kDa from the conditioned preparation under conditions to inhibit RNA degradation to enrich the miRNA species in the conditioned preparation and to maintain the relative abundance of each of the miRNA species so as to obtain a composition comprising miRNAs species; and (iv) formulating the composition of step (iii), under conditions to inhibit RNA degradation and to maintain the relative abundance of each of the miRNA species, in the acellular pro-tolerogenic conditioned preparation for administration to a subject,
Concrete comprising a binder consisting of cement and mineral addition(s), aggregates of agro-sourced origin, a hardening accelerator, and water, the components of the concrete being present in the following proportions: - a proportion by weight of mineral addition(s), relative to cement, in the range from 100% to 800%, preferably in the range from 200% to 700%; - a proportion by volume of aggregates of agro-sourced origin, relative to the binder, in the range from 200% to 350%, preferably in the range from 230% to 330%; - a proportion by weight of hardening accelerator, relative to the binder, in the range from 3.5% to 7.5%, preferably in the range from 4% to 6%; - a proportion by weight of water, relative to the binder, in the range from 30% to 100%, preferably in the range from 40% to 100%; wherein the cement is a Portland cement as defined in standard EN 197-1, and wherein the mineral addition(s) is (are) selected from: limestone additions as defined in standard NF P 18-508; silica additions as defined in standard NF P 18-509; blast furnace slags as defined in standard EN 15167-1; fly ash as defined in standard EN 450-1; silica fume as defined in standard EN 13263-1; metakaolin as defined in standard NF P 18-513; or a mixture of these compounds. - a proportion by weight of mineral addition(s), relative to cement, in the range from 100% to 800%, preferably in the range from 200% to 700%; - a proportion by volume of aggregates of agro-sourced origin, relative to the binder, in the range from 200% to 350%, preferably in the range from 230% to 330%; - a proportion by weight of hardening accelerator, relative to the binder, in the range from 3.5% to 7.5%, preferably in the range from 4% to 6%; - a proportion by weight of water, relative to the binder, in the range from 30% to 100%, preferably in the range from 40% to 100%; wherein the cement is a Portland cement as defined in standard EN 197-1, and wherein the mineral addition(s) is (are) selected from: limestone additions as defined in standard NF P 18-508; silica additions as defined in standard NF P 18-509; blast furnace slags as defined in standard EN 15167-1; fly ash as defined in standard EN 450-1; silica fume as defined in standard EN 13263-1; metakaolin as defined in standard NF P 18-513; or a mixture of these compounds.
Electric compressor comprising a compression mechanism rotated by a drive device that extends through a main casing delimiting an internal volume inside which an electric motor is installed, the electric motor including a stator and a rotor, which extends at least partially on the outer periphery of the stator, said drive device including the rotor, solidly connected to a shaft, which extends through a plate solidly connected to the main casing, and a first rotation means between the shaft and the plate characterized in that it includes a second rotation means between the drive device and the plate, the first rotation means has an axis of rotation and the second rotation means extends in a plane, said plane and said axis extending angularly one in relation to the other, and the rotor includes a support to which a multiplicity of permanent magnets is solidly connected, said multiplicity of permanent magnets and the stator being offset, said stator being offset toward the compression mechanism.
A method for producing or repairing a turbomachine part by means of a laser beam, wherein a nozzle sprays a metal powder towards a substrate, so as to produce the part by successive depositions of layers on top of each other, in one direction, therefore making the nozzle follow a trajectory, characterized in that a programmed deposition machine is operated, so that the following steps are performed: - the trajectory of the nozzle is initially defined in a pre-determined manner, which includes a definition of said trajectory along a Z axis corresponding to said direction of deposition of the layers and a height of the part, and then - during the production of the part: -- referring to an orientation parallel to the direction of deposition of the layers (11 i), a theoretical reference distance that has been previously recorded and a real distance (Di) which is then measured are compared, and -- the trajectory of the nozzle is modified along said Z axis on the basis of a non null deviation threshold between the theoretical reference distance and the measured real distance. - the trajectory of the nozzle is initially defined in a pre-determined manner, which includes a definition of said trajectory along a Z axis corresponding to said direction of deposition of the layers and a height of the part, and then - during the production of the part: -- referring to an orientation parallel to the direction of deposition of the layers (11 i), a theoretical reference distance that has been previously recorded and a real distance (Di) which is then measured are compared, and -- the trajectory of the nozzle is modified along said Z axis on the basis of a non null deviation threshold between the theoretical reference distance and the measured real distance. -- referring to an orientation parallel to the direction of deposition of the layers (11 i), a theoretical reference distance that has been previously recorded and a real distance (Di) which is then measured are compared, and -- the trajectory of the nozzle is modified along said Z axis on the basis of a non null deviation threshold between the theoretical reference distance and the measured real distance.
A changing device having a changing head, which is mounted so it is rotatable about an axis of rotation, having at least two tool receptacles (3, 4, 17, 18), which are provided at different positions, having at least one tool arranged thereon in each case, and a rotating device to rotate one of the tools into an operating position, characterized in that the tools are formed by clamping and/or centering devices (5, 6, 15, 16), which are embodied differently to accommodate and/or center various tools, and that the rotating device comprises a Geneva drive.
Suspending arm for an electrical appliance in particular for the equipment in an operating room, said suspending arm comprising a multifunction head provided with main mechanical and electrical connectors (33, 34, 4) intended to cooperate respectively with secondary mechanical and electrical connectors (133, 134, 104) of said electrical appliance in order to ensure removable mechanical and electrical connections between said electrical appliance and said multifunction head, characterized in that said main mechanical connector (33, 34) comprises a main fixed case arranged so as to define a main slide transversal to the longitudinal axis of said suspending arm and defining a main housing provided with a main frontal opening, in that said main electrical connector comprises at least one main electrical plug coupled with actuation means (41, 37, 50, 5, 51) arranged so as to move said plug longitudinally between a retracted position in which it is retracted into said main housing and allows the engagement of said main (33, 34) and secondary (133, 134) mechanical connectors and an advanced position in which it protrudes at least partly through said main frontal opening so as to be engaged with said secondary electrical connector and to electrically connect said main and secondary electrical connectors (4, 104) to one another, in that said main electrical plug is prolonged by at least one guiding finger extending perpendicularly to said longitudinal axis, said guiding finger being arranged so as to extend through a longitudinal groove in the wall of said main case and to move in a cam groove in a cam able to swivel with respect to said main case so that the swiveling of said cam groove with respect to said main case causes said main electrical plug to move between its retracted and advanced positions.
Microprocessor system, implementable or implemented in a mobile terminal, and having: - a normal operating system (HLOS) set up to produce and maintain an unsecured runtime environment, - a security operating system (MobiCore) set up to produce and maintain a secure runtime environment, wherein the unsecured runtime environment and the secure runtime environment each have an operating system level, a hardware level and an application level, and - an operating system interface (MobiCore driver) between the normal operating system (HLOS) and the security operating system (MobiCore), which is set up to control communication between the unsecured runtime environment and the secure runtime environment in secure fashion at operating system level by virtue of access operations between the unsecured runtime environment and the secure runtime environment at operating system level being effected via a security driver, characterized by at least one filter interface (virtual I2C drive; TLC) that has a first, unsecured filter interface section, set up for execution in the unsecured runtime environment, and a second, secure filter interface section, set up for execution in the secure runtime environment, and that is set up to control communication between the unsecured runtime environment and the secure runtime environment in secure fashion at a level different from the operating system level. - a normal operating system (HLOS) set up to produce and maintain an unsecured runtime environment, - a security operating system (MobiCore) set up to produce and maintain a secure runtime environment, wherein the unsecured runtime environment and the secure runtime environment each have an operating system level, a hardware level and an application level, and - an operating system interface (MobiCore driver) between the normal operating system (HLOS) and the security operating system (MobiCore), which is set up to control communication between the unsecured runtime environment and the secure runtime environment in secure fashion at operating system level by virtue of access operations between the unsecured runtime environment and the secure runtime environment at operating system level being effected via a security driver,
A computer implemented method of monitoring a condition of a pump, comprising: receiving, at a computing device, one or more signals indicative of one or more of a characteristic of a fluid flow at a first point on a flow path, the characteristic of the fluid flow at a second point on the flow path, and a difference in the characteristic of the fluid flow at the first point and at the second point, wherein the flow path is a path through which a fluid leakage flows from a case drain of the pump; determining, by the computing device based on the one or more signals, a fluid leakage flow rate through the flow path; determining, by the computing device, a pump efficiency based on the fluid leakage flow rate and a nominal fluid flow rate for the pump, wherein the nominal fluid flow rate is an optimal fluid flow rate for the pump when operating with a minimal amount of the fluid leakage; determining, by the computing device, whether the pump efficiency has dropped below a designated efficiency threshold; if the pump efficiency has dropped below the designated efficiency threshold, predicting, by the computing device, an impending pump failure; and in response to predicting the impending pump failure, generating, by the computing device, a first alert indicative of the impending pump failure. receiving, at a computing device, one or more signals indicative of one or more of a characteristic of a fluid flow at a first point on a flow path, the characteristic of the fluid flow at a second point on the flow path, and a difference in the characteristic of the fluid flow at the first point and at the second point, wherein the flow path is a path through which a fluid leakage flows from a case drain of the pump; determining, by the computing device based on the one or more signals, a fluid leakage flow rate through the flow path; determining, by the computing device, a pump efficiency based on the fluid leakage flow rate and a nominal fluid flow rate for the pump, wherein the nominal fluid flow rate is an optimal fluid flow rate for the pump when operating with a minimal amount of the fluid leakage; determining, by the computing device, whether the pump efficiency has dropped below a designated efficiency threshold; if the pump efficiency has dropped below the designated efficiency threshold, predicting, by the computing device, an impending pump failure; and in response to predicting the impending pump failure, generating, by the computing device, a first alert indicative of the impending pump failure.
A circuit suitable for capacitive sensing, comprising: carrier generation circuitry to generate a carrier signal at a carrier frequency; reference circuitry to generate a reference signal; carrier/drive signal path circuitry to drive a carrier/drive signal out through an output node, the carrier/drive signal useable for capacitive sensing, including: modulation circuitry to modulate the reference signal with the carrier signal to generate the carrier/drive signal at the carrier frequency; and drive circuitry to drive the carrier/drive signal out through the output node; and sense signal path circuitry to receive at an input node an up-modulated sense capacitance signal corresponding to measured capacitance from capacitive sensing, wherein the sense capacitance signal is up-modulated to the carrier frequency based on the carrier/drive signal, including: amplifier circuitry to generate an amplified up-modulated sense capacitance signal; and demodulation circuitry to demodulate the amplified up-modulated sense capacitance signal based on the carrier signal, generating a demodulated sense capacitance signal; characterised in that the amplifier circuitry is a transimpedance amplifier including a feedback resistor coupled to the amplifier inverting input, which is coupled to receive the up-modulated sense capacitance signal, with the carrier/drive signal path circuitry further including an integrator to integrate the carrier/drive signal. carrier generation circuitry to generate a carrier signal at a carrier frequency; reference circuitry to generate a reference signal; carrier/drive signal path circuitry to drive a carrier/drive signal out through an output node, the carrier/drive signal useable for capacitive sensing, including: modulation circuitry to modulate the reference signal with the carrier signal to generate the carrier/drive signal at the carrier frequency; and drive circuitry to drive the carrier/drive signal out through the output node; and sense signal path circuitry to receive at an input node an up-modulated sense capacitance signal corresponding to measured capacitance from capacitive sensing, wherein the sense capacitance signal is up-modulated to the carrier frequency based on the carrier/drive signal, including: amplifier circuitry to generate an amplified up-modulated sense capacitance signal; and demodulation circuitry to demodulate the amplified up-modulated sense capacitance signal based on the carrier signal, generating a demodulated sense capacitance signal; characterised in that the amplifier circuitry is a transimpedance amplifier including a feedback resistor coupled to the amplifier inverting input, which is coupled to receive the up-modulated sense capacitance signal, with the carrier/drive signal path circuitry further including an integrator to integrate the carrier/drive signal.
An implantable medical device, IMD, configured for use as part of a cardiac therapy system comprising a leadless cardiac pacemaker, LCP (14, 40), for delivering pacing therapy and the IMD, the IMD comprising: a plurality of electrodes (22, 24, 26) for sensing cardiac activity; communication circuitry configured to communicate with a LCP (14, 40); and operational circuitry configured to receive sensed cardiac signals from the plurality of electrodes and analyze cardiac activity, characterized in that the operational circuitry comprises: pace timing means configured to determine when pace therapy is delivered by a LCP; P-wave to Pace means configured to determine a P-wave to Pace interval by analysis of a segment of the sensed cardiac signals from the plurality of electrodes including a time period prior to pace therapy delivery from a LCP; comparing means configured to determine whether the P-wave to Pace interval is in a desired range or requires adjustment; and adjustment means configured to adjust a parameter of the pacing therapy delivered by a LCP based on the determination of the comparing means. a plurality of electrodes (22, 24, 26) for sensing cardiac activity; communication circuitry configured to communicate with a LCP (14, 40); and operational circuitry configured to receive sensed cardiac signals from the plurality of electrodes and analyze cardiac activity, characterized in that the operational circuitry comprises: pace timing means configured to determine when pace therapy is delivered by a LCP; P-wave to Pace means configured to determine a P-wave to Pace interval by analysis of a segment of the sensed cardiac signals from the plurality of electrodes including a time period prior to pace therapy delivery from a LCP; comparing means configured to determine whether the P-wave to Pace interval is in a desired range or requires adjustment; and adjustment means configured to adjust a parameter of the pacing therapy delivered by a LCP based on the determination of the comparing means. pace timing means configured to determine when pace therapy is delivered by a LCP; P-wave to Pace means configured to determine a P-wave to Pace interval by analysis of a segment of the sensed cardiac signals from the plurality of electrodes including a time period prior to pace therapy delivery from a LCP; comparing means configured to determine whether the P-wave to Pace interval is in a desired range or requires adjustment; and adjustment means configured to adjust a parameter of the pacing therapy delivered by a LCP based on the determination of the comparing means.
Device for collecting vegetables such as melons including a chassis, a collection unit, and securing means capable of linking said chassis to an agricultural vehicle, said collection unit including means for guiding the vegetables, means for transferring the vegetables onto a conveyor and at least one conveyor, characterised in that said chassis comprises means for supporting said collection unit, including a bearing structure on which said collection unit rests, said structure including upper and lower arms connected by at least one jack allowing for damping and adjustment according to the load of said collection unit, allowing said supporting means to place said collection unit in a cantilevered fashion so as to limit the force exerted on the ground by said collection unit.
A floating construction comprising a container filled fully or partially with water, the lower portion of the container being located within a surrounding body of water and the water surface level of the surrounding body of water being substantially lower that the water surface level inside the container, the container comprising transparent walls or walls with transparent sections and at least one open opening for entering the container, which at least one open opening is located below the surface level of the surrounding body of water, and which floating construction comprises space for spectators for observing activities taking place inside the container, characterized in that the floating construction comprises at least one ballast tank (3, 3'), which ballast tank is connected to the container with a controllable pressure connection (4, 5, 4', 5'), and which ballast tank has controllable water connection (6, 7, 6'; 7') to the surrounding body of water.
Vehicle pane module for installation in a car body opening of a vehicle, the vehicle pane module being prefabricated and equipped with at least one vehicle pane and at least one functional component of the vehicle, which functional component, together with the vehicle pane, can be inserted as a constituent part of the vehicle pane module into the car body opening of the vehicle, characterized in that the vehicle pane module has a frame which supports the vehicle pane and the at least one functional component indirectly or directly, and the interior region of which frame is filled in sections by the vehicle pane and in sections by the functional component.
A method for automatic verification of the RF signal quality in telematics devices, characterized in that the quality parameters of the RF signals are compared with a predeterminable reference characteristic curve stored in the telematics device, wherein when complying with a predetermined tolerance, a correct installation is automatically reported and / or wrong installation is automatically reported when non-complying with a predetermined tolerance.