A method of operating a readout system, the method comprising: providing a sensor array (202, 302) comprising a plurality of sensors (104, 304), each sensor of the plurality of sensors including a resonator with frequency characteristics different from the resonator of each other sensor of the plurality of sensors (104, 304), wherein at least one of the plurality of sensors (104, 304) acquires a negative charge or a positive charge so as to create an attractive electrostatic force or a repulsive force with positively charged analytes; collecting a single readout signal at a single conductive path, wherein the single readout signal is indicative of a plurality of output signals from the sensor array (202, 302), each output signal of the plurality of output signals corresponding to one of the plurality of sensors (202, 302); based on the single readout signal, performing an analysis of the plurality of output signals to determine the frequency characteristics associated with the resonator of each sensor of the plurality of sensors (104, 304); and based on the analysis of the plurality of output signals: identifying a plurality of resonant frequencies including a first resonant frequency and a second resonant frequency, each resonant frequency of the plurality of resonant frequencies corresponding to one of the plurality of output signals and one of the plurality of sensors (104, 304), wherein each resonant frequency of the plurality of resonant frequencies is operable to change upon adsorption of an analyte on each resonator; and detecting a first frequency shift associated with the first resonant frequency caused by a first analyte being adsorbed on a first resonator and a second frequency shift associated with the second resonant frequency caused by a second analyte being adsorbed on a second resonator, wherein the first frequency shift and the second frequency shift are both detected from collection of the single readout signal. providing a sensor array (202, 302) comprising a plurality of sensors (104, 304), each sensor of the plurality of sensors including a resonator with frequency characteristics different from the resonator of each other sensor of the plurality of sensors (104, 304), wherein at least one of the plurality of sensors (104, 304) acquires a negative charge or a positive charge so as to create an attractive electrostatic force or a repulsive force with positively charged analytes; collecting a single readout signal at a single conductive path, wherein the single readout signal is indicative of a plurality of output signals from the sensor array (202, 302), each output signal of the plurality of output signals corresponding to one of the plurality of sensors (202, 302); based on the single readout signal, performing an analysis of the plurality of output signals to determine the frequency characteristics associated with the resonator of each sensor of the plurality of sensors (104, 304); and based on the analysis of the plurality of output signals: identifying a plurality of resonant frequencies including a first resonant frequency and a second resonant frequency, each resonant frequency of the plurality of resonant frequencies corresponding to one of the plurality of output signals and one of the plurality of sensors (104, 304), wherein each resonant frequency of the plurality of resonant frequencies is operable to change upon adsorption of an analyte on each resonator; and detecting a first frequency shift associated with the first resonant frequency caused by a first analyte being adsorbed on a first resonator and a second frequency shift associated with the second resonant frequency caused by a second analyte being adsorbed on a second resonator, wherein the first frequency shift and the second frequency shift are both detected from collection of the single readout signal. identifying a plurality of resonant frequencies including a first resonant frequency and a second resonant frequency, each resonant frequency of the plurality of resonant frequencies corresponding to one of the plurality of output signals and one of the plurality of sensors (104, 304), wherein each resonant frequency of the plurality of resonant frequencies is operable to change upon adsorption of an analyte on each resonator; and detecting a first frequency shift associated with the first resonant frequency caused by a first analyte being adsorbed on a first resonator and a second frequency shift associated with the second resonant frequency caused by a second analyte being adsorbed on a second resonator, wherein the first frequency shift and the second frequency shift are both detected from collection of the single readout signal.