mhurhangee/ep-ind-claims huggingface dataset:
A cell preparation for use in amelioration and/or treatment of a brain disorder associated with fetal growth retardation due to hypoxemia caused by placental or umbilical cord factors, or due to complex and chronic factors such as circulatory failure and malnutrition, comprising an effective amount of pluripotent stem cells positive for SSEA-3 isolated from mesenchymal tissue or cultured mesenchymal cells of a living organism, wherein the brain disorder associated with fetal growth retardation is selected from the group consisting of abnormal quality of movement, abnormal neurological development, cerebral palsy, cognitive impairment, and behavior disorder.
A spraying device comprising: a sprayer body coupled to an interchangeable cartridge containing a first fluid; the sprayer body comprising: a conduit for receiving a second fluid; a valve coupled to the conduit, the valve allowing passage of the second fluid through the valve to create a vacuum that draws the first fluid out of the interchangeable cartridge and into the valve without the need for a dip tube, the valve enabling the first and second fluids (36, 37) to mix and form an outlet stream; and an orifice for metering a predetermined amount of the first fluid into the valve to achieve a predetermined ratio of the first fluid to the second fluid in the outlet stream, wherein the metering orifice is disposed in the interchangeable cartridge for customizing the ratio based on the particular first fluid contained within the interchangeable cartridge. a sprayer body coupled to an interchangeable cartridge containing a first fluid; the sprayer body comprising: a conduit for receiving a second fluid; a valve coupled to the conduit, the valve allowing passage of the second fluid through the valve to create a vacuum that draws the first fluid out of the interchangeable cartridge and into the valve without the need for a dip tube, the valve enabling the first and second fluids (36, 37) to mix and form an outlet stream; and an orifice for metering a predetermined amount of the first fluid into the valve to achieve a predetermined ratio of the first fluid to the second fluid in the outlet stream, wherein the metering orifice is disposed in the interchangeable cartridge for customizing the ratio based on the particular first fluid contained within the interchangeable cartridge. a conduit for receiving a second fluid; a valve coupled to the conduit, the valve allowing passage of the second fluid through the valve to create a vacuum that draws the first fluid out of the interchangeable cartridge and into the valve without the need for a dip tube, the valve enabling the first and second fluids (36, 37) to mix and form an outlet stream; and an orifice for metering a predetermined amount of the first fluid into the valve to achieve a predetermined ratio of the first fluid to the second fluid in the outlet stream, wherein the metering orifice is disposed in the interchangeable cartridge for customizing the ratio based on the particular first fluid contained within the interchangeable cartridge.
An accessory for a syringe having a plunger and a barrel, the accessory comprising: a housing configured to removably attach to the finger flange of the barrel; the housing including a holder and a base wherein the holder mates with the base and wherein the holder is generally u-shaped and the base is generally u-shaped such that when the holder and base are mated they form an opening through which the plunger and rack can pass; and a rack configured to removably attach to the plunger such that the rack and the plunger are moveably disposed to pass through the opening, the rack being configured to intermittently contact the housing as the plunger is pressed into the barrel, wherein a number of intermittent contacts between the housing and the rack provides a feedback indicative of a distance the plunger has traveled relative to the barrel. a housing configured to removably attach to the finger flange of the barrel; the housing including a holder and a base wherein the holder mates with the base and wherein the holder is generally u-shaped and the base is generally u-shaped such that when the holder and base are mated they form an opening through which the plunger and rack can pass; and a rack configured to removably attach to the plunger such that the rack and the plunger are moveably disposed to pass through the opening, the rack being configured to intermittently contact the housing as the plunger is pressed into the barrel, wherein a number of intermittent contacts between the housing and the rack provides a feedback indicative of a distance the plunger has traveled relative to the barrel.
A method for preparing a three-dimensionally cultured skin model comprising dermis and epidermis, comprising: (a) inoculating a composition, which comprises murine fibroblasts or human fibroblasts; and a combination of native collagen and atelocollagen, into a culture dish and solidifying the same to prepare the dermis, wherein atelocollagen and native collagen are combined in a ratio of 1:0.1 to 1:20; (b) inoculating keratinocytes on the dermis prepared in step (a) and culturing until a cell sheet is formed thereon; and (c) raising the cell sheet in step (b) to the air/liquid interface to form the upper layers of epidermis. (a) inoculating a composition, which comprises murine fibroblasts or human fibroblasts; and a combination of native collagen and atelocollagen, into a culture dish and solidifying the same to prepare the dermis, wherein atelocollagen and native collagen are combined in a ratio of 1:0.1 to 1:20; (b) inoculating keratinocytes on the dermis prepared in step (a) and culturing until a cell sheet is formed thereon; and (c) raising the cell sheet in step (b) to the air/liquid interface to form the upper layers of epidermis.
An instrument comprising:- a first jaw and second jaw, the first jaw being pivotally movable relative to the second jaw, at least the first jaw having a pointed or sharp feature such as a tissue engaging feature at or adjacent to a distal end thereof; and a first protective element extending from or extendable from the distal end of the first jaw to provide a protective distal tip which extends distally of the pointed or sharp feature, characterised in that the protector element comprises a loop which extends around the engagement tip of the pointed or sharp feature. a first jaw and second jaw, the first jaw being pivotally movable relative to the second jaw, at least the first jaw having a pointed or sharp feature such as a tissue engaging feature at or adjacent to a distal end thereof; and a first protective element extending from or extendable from the distal end of the first jaw to provide a protective distal tip which extends distally of the pointed or sharp feature, characterised in that the protector element comprises a loop which extends around the engagement tip of the pointed or sharp feature.
An illumination lamp adapted to be connected to an inverter ballast for a fluorescent lamp, the illumination lamp comprising: a light emitting diode; a rectifier circuit (24, 25) configured to rectify an AC voltage supplied by the inverter ballast for a fluorescent lamp and supply the rectified voltage to the light emitting diode; and a voltage detection circuit configured to cause a current not to flow from the inverter ballast for a fluorescent lamp to the rectifier circuit (24, 25) when a voltage applied by the inverter ballast for a fluorescent lamp is less than a predetermined voltage, and cause the current to flow from the inverter ballast for a fluorescent lamp to the rectifier circuit (24, 25) when the voltage becomes equal to or greater than the predetermined voltage; wherein the voltage detection circuit includes a DC impedance element and a Zener diode connected in series to the DC impedance element; and wherein the rectifier circuit (24, 25) outputs the rectified voltage to a plus side wire connection and a minus side wire connection, characterised in that the Zener diode, a cathode of which is facing the rectifier circuit (24, 25), is inserted into the plus side wire connection, and the DC impedance element is connected between an anode of the Zener diode and the minus side wire connection. a light emitting diode; a rectifier circuit (24, 25) configured to rectify an AC voltage supplied by the inverter ballast for a fluorescent lamp and supply the rectified voltage to the light emitting diode; and a voltage detection circuit configured to cause a current not to flow from the inverter ballast for a fluorescent lamp to the rectifier circuit (24, 25) when a voltage applied by the inverter ballast for a fluorescent lamp is less than a predetermined voltage, and cause the current to flow from the inverter ballast for a fluorescent lamp to the rectifier circuit (24, 25) when the voltage becomes equal to or greater than the predetermined voltage; wherein the voltage detection circuit includes a DC impedance element and a Zener diode connected in series to the DC impedance element; and wherein the rectifier circuit (24, 25) outputs the rectified voltage to a plus side wire connection and a minus side wire connection, characterised in that the Zener diode, a cathode of which is facing the rectifier circuit (24, 25), is inserted into the plus side wire connection, and the DC impedance element is connected between an anode of the Zener diode and the minus side wire connection.
A device for compensating for pressure changes in a vial comprising: (a) a first conduit for fluidly connecting the vial to an external port; (b) a second conduit for enabling outflow of gasses from the vial, said second conduit having a valve for preventing outflow of liquid from the vial through said second conduit; (c) a third conduit for enabling one-way outflow of gasses from a pliable reservoir; and (d) a substantially inelastic pliable reservoir being fluidly and separately connected to said second conduit and said third conduit and having an expanded volume larger than a fluid volume of the vial, said pliable reservoir being configured as a bag. (a) a first conduit for fluidly connecting the vial to an external port; (b) a second conduit for enabling outflow of gasses from the vial, said second conduit having a valve for preventing outflow of liquid from the vial through said second conduit; (c) a third conduit for enabling one-way outflow of gasses from a pliable reservoir; and (d) a substantially inelastic pliable reservoir being fluidly and separately connected to said second conduit and said third conduit and having an expanded volume larger than a fluid volume of the vial, said pliable reservoir being configured as a bag.
A single-pole switching unit having a housing comprising: - a moving contact bridge, - a pair of fixed contacts (34, 36) cooperating with said moving contact bridge and respectively connected to a current intake conductor, - two arc cutoff chambers respectively opening onto an opening volume of the moving contact bridge, each cutoff chamber being connected to at least one exhaust channel, - at least one exhaust channel comprising a rotating gate designed to be rotated around an axis substantially perpendicular to the exhaust channel by the passage of cutoff gases, the rotation of the rotating gate from a first obstruction position to a second triggering position being designed to actuate triggering means to cause the opening of the contacts, the rotation of the rotating gate being defined by an angle of rotation, comprised between an initial angle value in the obstruction position and a final angle value, characterized in that the rotating gate comprises one edge positioned across from an inner wall of the exhaust channel, in the first obstruction position, said edge being positioned at a first distance from said inner wall of the exhaust channel in the first obstruction position, said edge being able to move away from the wall of the exhaust channel during the rotation of the rotating gate, the position of the rotating gate defining at least one gas passage section (62, 64), the arrangement of the rotating gate and the inner wall being such that the distance between said edge and said inner wall remains constant and equal to said first distance up to a first rotation angle threshold value of the rotating gate, then increases linearly up to a second rotation angle threshold value corresponding to complete opening of the discharge channel. - a moving contact bridge, - a pair of fixed contacts (34, 36) cooperating with said moving contact bridge and respectively connected to a current intake conductor, - two arc cutoff chambers respectively opening onto an opening volume of the moving contact bridge, each cutoff chamber being connected to at least one exhaust channel, - at least one exhaust channel comprising a rotating gate designed to be rotated around an axis substantially perpendicular to the exhaust channel by the passage of cutoff gases, the rotation of the rotating gate from a first obstruction position to a second triggering position being designed to actuate triggering means to cause the opening of the contacts, the rotation of the rotating gate being defined by an angle of rotation, comprised between an initial angle value in the obstruction position and a final angle value,
Device for opening a door, in particular a revolving door or a sliding door, comprising: a handheld transmitter for being actuated by a person; a drive for driving the door; a radio receiver for receiving radio signals in the form of opening signals; an energy store; a pressure switch for electrically connecting the energy store and the radio receiver in response to the driven door; a control unit with a transmitter for transmitting the opening signal to the radio receiver, characterized in that the control unit receives a position signal and a holding relay is provided for maintaining the energy supply between the energy store and the radio receiver during the opening operation. a handheld transmitter for being actuated by a person; a drive for driving the door; a radio receiver for receiving radio signals in the form of opening signals; an energy store; a pressure switch for electrically connecting the energy store and the radio receiver in response to the driven door; a control unit with a transmitter for transmitting the opening signal to the radio receiver, characterized in that the control unit receives a position signal and a holding relay is provided for maintaining the energy supply between the energy store and the radio receiver during the opening operation.
A GUCY2C agonist for use in the treatment of Parkinson's disease in an individual, further comprising administering a PDE inhibitor to the individual.
A proton battery apparatus, comprising: a first graphene oxide-based material having a first concentration of functional groups; a second material having a second concentration of functional groups; a junction defined by an interface of the first graphene oxide-based material positioned adjacent and in contact with the second material; and charge collectors formed on each of the first graphene oxide-based material and the second material; wherein the apparatus is configured to allow exposure of the junction to water to cause dissociation of protons from the functional groups of the first graphene oxide-based material and the second material, the different concentrations of functional groups giving rise to different concentrations of protons being dissociated from the first graphene oxide-based material and the second material, and a corresponding migration of protons across the junction to generate a voltage. a first graphene oxide-based material having a first concentration of functional groups; a second material having a second concentration of functional groups; a junction defined by an interface of the first graphene oxide-based material positioned adjacent and in contact with the second material; and charge collectors formed on each of the first graphene oxide-based material and the second material; wherein the apparatus is configured to allow exposure of the junction to water to cause dissociation of protons from the functional groups of the first graphene oxide-based material and the second material, the different concentrations of functional groups giving rise to different concentrations of protons being dissociated from the first graphene oxide-based material and the second material, and a corresponding migration of protons across the junction to generate a voltage.
A broach for a broaching machine, which comprises a toothed sheet formed by one or more segments arranged in longitudinal correlation and a sheet-holding support in which the toothed sheet is placed; wherein the sheet-holding support has a recess (3.1) into which a base (4.1) of the toothed sheet with matching configuration fits, in order to establish mechanical coupling between the two, and in that the sheet-holding support includes tightening means for securing the toothed sheet in position in the sheet-holder; characterized in that the toothed sheet comprises hard-metal teeth. wherein the sheet-holding support has a recess (3.1) into which a base (4.1) of the toothed sheet with matching configuration fits, in order to establish mechanical coupling between the two, and in that the sheet-holding support includes tightening means for securing the toothed sheet in position in the sheet-holder; characterized in that the toothed sheet comprises hard-metal teeth.
An assembly for rotational equipment, comprising: a plurality of seal shoes arranged around an axis in an annular array, the seal shoes comprising a first seal shoe; a seal base circumscribing the annular array of the seal shoes; and a plurality of spring elements, each of the spring elements radially between and connecting a respective one of the seal shoes and the seal base, the spring elements comprising a first spring element that includes: a first mount connected to the first seal shoe; a second mount connected to the seal base and disposed a circumferential distance away from the first mount; and a spring beam extending longitudinally along a non-straight centerline between and connected to the first mount and the second mount, characterised in that the non-straight centerline has a variable radius to the axis as the spring beam extends longitudinally between the first mount and the second mount, and the spring beam includes a curved center portion with a substantially constant radius (R c) and opposing end portions (84, 86) with radii (R v) that are different from the constant radius (R c) of the curved center portion. a plurality of seal shoes arranged around an axis in an annular array, the seal shoes comprising a first seal shoe; a seal base circumscribing the annular array of the seal shoes; and a plurality of spring elements, each of the spring elements radially between and connecting a respective one of the seal shoes and the seal base, the spring elements comprising a first spring element that includes: a first mount connected to the first seal shoe; a second mount connected to the seal base and disposed a circumferential distance away from the first mount; and a spring beam extending longitudinally along a non-straight centerline between and connected to the first mount and the second mount, characterised in that the non-straight centerline has a variable radius to the axis as the spring beam extends longitudinally between the first mount and the second mount, and a first mount connected to the first seal shoe; a second mount connected to the seal base and disposed a circumferential distance away from the first mount; and a spring beam extending longitudinally along a non-straight centerline between and connected to the first mount and the second mount, characterised in that the non-straight centerline has a variable radius to the axis as the spring beam extends longitudinally between the first mount and the second mount, and the spring beam includes a curved center portion with a substantially constant radius (R c) and opposing end portions (84, 86) with radii (R v) that are different from the constant radius (R c) of the curved center portion.
An optically variable security element for securing valuable articles, whose areal expanse defines a z-axis perpendicular thereto, having a reflective areal region that displays at least two appearances that are perceptible from different viewing directions, - the reflective areal region including two relief structures that are arranged at different height levels in the z-direction and form a lower-lying and a higher-lying relief structure, each of which is furnished with a reflection-increasing coating that follows the relief profile, - the higher-lying relief structure displaying a first optically variable effect in a first color, - the lower-lying relief structure being visible through the higher-lying reflection-increasing coating itself, or through grid spaces or gaps in the higher-lying reflection-increasing coating, and displaying a second optically variable effect in a second, different color, and - the security element being furnished, in an interior layer that is provided contiguously or in some regions, with at least one machine-readable feature substance, characterized in that - the security element includes an authenticating feature having two different machine-readable feature substances that are present in separate planar layers of the security element, - a first layer having a first of the two machine-readable feature substances being arranged below the two relief structures and a second layer having a second of the two machine-readable feature substances being arranged above the two relief structures. - the reflective areal region including two relief structures that are arranged at different height levels in the z-direction and form a lower-lying and a higher-lying relief structure, each of which is furnished with a reflection-increasing coating that follows the relief profile, - the higher-lying relief structure displaying a first optically variable effect in a first color, - the lower-lying relief structure being visible through the higher-lying reflection-increasing coating itself, or through grid spaces or gaps in the higher-lying reflection-increasing coating, and displaying a second optically variable effect in a second, different color, and - the security element being furnished, in an interior layer that is provided contiguously or in some regions, with at least one machine-readable feature substance, - the security element includes an authenticating feature having two different machine-readable feature substances that are present in separate planar layers of the security element, - a first layer having a first of the two machine-readable feature substances being arranged below the two relief structures and a second layer having a second of the two machine-readable feature substances being arranged above the two relief structures.