A compound of formula II wherein X is R 1 is optionally substituted aryl-C 1 -C 10 -alkyl, or optionally substituted aryl; R 2 is -CO 2 H, optionally substituted heterocyclyl, optionally substituted -CONHSO 2 R 14, optionally substituted -CONHCOR 13, optionally substituted -SO 2 NHCOR 13 or optionally substituted -NHSO 2 R 14; R 13 is optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; R 14 is CF 3 or optionally substituted C 1 -C 10 alkyl; R 3 is H, halo, CN, optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; R 4 is H or optionally substituted C 1 -C 10 alkyl; R 5 and R 6 are independently H, optionally substituted C 1 -C 10 alkyl or OH, or R 5 and R 6 are taken together with the carbon to which they are attached to form R 7 and R 8 are independently H, optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl, optionally substituted C 1 -C 10 alkoxy, optionally substituted aryl, optionally substituted aryl-C 1 -C 10 -alkyl, optionally substituted 5- to 8-membered heteroaryl, or optionally substituted C 3 -C 8 cycloalkyl; R 9 is optionally substituted aryl, optionally substituted C 1 -C 10 alkylaryl, optionally substituted C 1 -C 10 alkoxyaryl, optionally substituted heteroaryl, optionally substituted C 1 -C 10 -alkyl heteroaryl, optionally substituted aryl-C 1 -C 10 -alkylaryl, optionally substituted aryloxyaryl, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl, optionally substituted C 2 -C 10 alkynyl, optionally substituted C 3 -C 8 cycloalkyl, or optionally substituted C 4 -C 8 cycloalkenyl; wherein, when a substituent is noted as "optionally substituted", the substituents are selected from alkyl, cycloalkyl, aryl, heterocyclo, halo, hydroxy, alkoxy, oxo, alkanoyl, aryloxy, alkanoyloxy, amino, alkylamino, arylamino, arylalkylamino, disubstituted amines in which the 2 amino substituents are selected from alkyl, aryl or arylalkyl; alkanoylamino, aroylamino, aralkanoylamino, substituted alkanoylamino, substituted arylamino, substituted aralkanoylamino, thiol, alkylthio, arylthio, arylalkylthio, alkylthiono, arylthiono, arylalkylthiono, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, sulfonamide, substituted sulfonamido, nitro, cyano, carboxy, carbamyl, substituted carbamyl, alkoxycarbonyl, aryl, substituted aryl, guanidino, heterocyclyl, and substituted heterocyclyl; wherein the term "aryl", either alone or as part of a larger moiety such as "aralkyl", "aralkoxy", or "aryloxyalkyl", refers to monocyclic, bicyclic and tricyclic ring systems having a total of five to 15 ring members, wherein at least one ring in the system is aromatic and wherein each ring in the system contains three to seven ring members; and/or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. X is R 1 is optionally substituted aryl-C 1 -C 10 -alkyl, or optionally substituted aryl; R 2 is -CO 2 H, optionally substituted heterocyclyl, optionally substituted -CONHSO 2 R 14, optionally substituted -CONHCOR 13, optionally substituted -SO 2 NHCOR 13 or optionally substituted -NHSO 2 R 14; R 13 is optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; R 14 is CF 3 or optionally substituted C 1 -C 10 alkyl; R 3 is H, halo, CN, optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; R 4 is H or optionally substituted C 1 -C 10 alkyl; R 5 and R 6 are independently H, optionally substituted C 1 -C 10 alkyl or OH, or R 5 and R 6 are taken together with the carbon to which they are attached to form R 7 and R 8 are independently H, optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 -alkoxy-C 1 -C 10 -alkyl, optionally substituted C 1 -C 10 alkoxy, optionally substituted aryl, optionally substituted aryl-C 1 -C 10 -alkyl, optionally substituted 5- to 8-membered heteroaryl, or optionally substituted C 3 -C 8 cycloalkyl; R 9 is optionally substituted aryl, optionally substituted C 1 -C 10 alkylaryl, optionally substituted C 1 -C 10 alkoxyaryl, optionally substituted heteroaryl, optionally substituted C 1 -C 10 -alkyl heteroaryl, optionally substituted aryl-C 1 -C 10 -alkylaryl, optionally substituted aryloxyaryl, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl, optionally substituted C 2 -C 10 alkynyl, optionally substituted C 3 -C 8 cycloalkyl, or optionally substituted C 4 -C 8 cycloalkenyl;