mhurhangee/ep-ind-claims huggingface dataset:
A hydrogel formulation for topical administration comprising an oxidative reductive potential water solution and 0.1 weight-percent to 10 weight-percent of sodium magnesium fluorosilicate, wherein the solution comprises 10 ppm to 400 ppm of free chlorine species, wherein the free chlorine species is selected from the group consisting of hypochlorous acid, hypochlorite ion, sodium hypochlorite, and dissolved chlorine gas, wherein the formulation has a pH of from 6.2 to 7.8, and wherein the formulation further comprises from 0.01 weight-percent to 5.0 weight-percent of sodium phosphate.
A method of operating an internal combustion engine having at least two cylinders and at least one exhaust valve providing selective communication between each cylinder and an exhaust manifold, the method of operating the engine comprising actuating the exhaust valves in each cylinder and further comprising the steps of: providing one or more first cams (200, 220, 230, 240) having a compression-release lobe (202, 232) and a main exhaust lobe (204, 222) adapted to transfer valve actuation motion to a first exhaust valve associated with a first cylinder; providing one or more second cams (210, 220, 230, 240) having an early exhaust valve opening lobe (212, 232) and a main exhaust lobe (214, 222) adapted to transfer valve actuation motion to a second exhaust valve associated with a second cylinder, wherein timing of valve actuation motion provided by the early exhaust valve opening lobe differs from timing of valve actuation motion provided by the compression-release lobe in that the compression-release lobe provides for the first exhaust valve being opened prior to a top dead center engine piston position and the early exhaust valve opening lobe provides for the second exhaust valve being opened as early as immediately after the top dead center engine piston position; and operating the engine in a first positive power mode of operation in which the first exhaust valve in the first cylinder is actuated for a main exhaust event (712, 512) without being actuated for a compression-release event (710, 510), and the second exhaust valve in the second cylinder is actuated for a main exhaust event (812, 612) without being actuated for an early exhaust valve opening event (810, 818, 814, 610). providing one or more first cams (200, 220, 230, 240) having a compression-release lobe (202, 232) and a main exhaust lobe (204, 222) adapted to transfer valve actuation motion to a first exhaust valve associated with a first cylinder; providing one or more second cams (210, 220, 230, 240) having an early exhaust valve opening lobe (212, 232) and a main exhaust lobe (214, 222) adapted to transfer valve actuation motion to a second exhaust valve associated with a second cylinder, wherein timing of valve actuation motion provided by the early exhaust valve opening lobe differs from timing of valve actuation motion provided by the compression-release lobe in that the compression-release lobe provides for the first exhaust valve being opened prior to a top dead center engine piston position and the early exhaust valve opening lobe provides for the second exhaust valve being opened as early as immediately after the top dead center engine piston position; and operating the engine in a first positive power mode of operation in which the first exhaust valve in the first cylinder is actuated for a main exhaust event (712, 512) without being actuated for a compression-release event (710, 510), and the second exhaust valve in the second cylinder is actuated for a main exhaust event (812, 612) without being actuated for an early exhaust valve opening event (810, 818, 814, 610).
Transmitter having a transmitter housing, an electronics unit and a display unit, wherein the electronics unit is designed for connection to a measured value sensor, wherein the electronics unit is connected to the display unit, and wherein the transmitter housing has at least one cable gland, characterized in that at least one connection module is arranged in the at least one cable gland, and that the at least one connection module comprises at least one operating element for communication with the display unit and/or the electronics unit.
A method for processing a structured surface of an embossing tool, in which the surface is provided with a first metallic coating over the entire area, and has at least one further metallic coating having a different degree of gloss in selected areas (7, 8, 9, 10, 11), characterized in that, on the first coating different degrees of gloss are produced in multiple selected areas (7, 8, 9, 10, 11), wherein a protective layer (mask) is partially applied on the first coating by means of a digital printing technique to define the selected areas (7, 8, 9, 10, 11) and the degrees of gloss are produced by a combination of metallic coatings, mechanical, or chemical subsequent treatments.
A roll cap that is mountable at an end (20, 22) of a spool of a roll of a ribbon supply (10, 11), comprising: a cap body having a first end, a second end opposite the first end, and a central axis (A-A) extending from the first end to the second end; a neck that extends from the first end toward the second end and that is sized to fit into the end of the spool; a first flange formed on the cap body at an end of the neck, the first flange is positioned between the neck and the second end; a second flange formed on the cap body at a position so that the first flange is between the neck and the second flange; the first flange and the second flange define a channel therebetween; and a protrusion projecting from the second end of the cap body in a direction away from the first end, and the protrusion is centrally located on the second end with the central axis extending through the center of the protrusion. a cap body having a first end, a second end opposite the first end, and a central axis (A-A) extending from the first end to the second end; a neck that extends from the first end toward the second end and that is sized to fit into the end of the spool; a first flange formed on the cap body at an end of the neck, the first flange is positioned between the neck and the second end; a second flange formed on the cap body at a position so that the first flange is between the neck and the second flange; the first flange and the second flange define a channel therebetween; and a protrusion projecting from the second end of the cap body in a direction away from the first end, and the protrusion is centrally located on the second end with the central axis extending through the center of the protrusion.
A sorption cycle - with a gaseous refrigerant and a liquid one-phase solution (12, 36, 46, 60) of the refrigerant in a solvent; - wherein the solution (12, 36, 46, 60) absorbs a medium-pressure partial flow (17, 34, 64) of the refrigerant at a medium-pressure level, and wherein the solution (12, 36, 46, 60) absorbs a high-pressure partial flow (26, 43, 73) of the refrigerant at a high-pressure level and wherein the solution (12, 36, 46, 60) emits heat generated from absorbing the medium-pressure partial flow and generated from absorbing the high-pressure partial flow to a heat sink (13, 31, 58) outside of the sorption cycle; and - wherein the solution (12, 36, 46, 60) after absorbing the refrigerant absorbs heat from a heat source (16, 53) outside of the sorption cycle and thus expels the refrigerant, characterized in that the solution (12, 36, 46, 60) emits heat generated by absorbing the medium-pressure partial flow (17, 34, 62) to the solution (12, 36, 46, 60) at the high-pressure level, so that the latter expels the high-pressure partial flow (26, 43, 73) of the refrigerant. - with a gaseous refrigerant and a liquid one-phase solution (12, 36, 46, 60) of the refrigerant in a solvent; - wherein the solution (12, 36, 46, 60) absorbs a medium-pressure partial flow (17, 34, 64) of the refrigerant at a medium-pressure level, and wherein the solution (12, 36, 46, 60) absorbs a high-pressure partial flow (26, 43, 73) of the refrigerant at a high-pressure level and wherein the solution (12, 36, 46, 60) emits heat generated from absorbing the medium-pressure partial flow and generated from absorbing the high-pressure partial flow to a heat sink (13, 31, 58) outside of the sorption cycle; and - wherein the solution (12, 36, 46, 60) after absorbing the refrigerant absorbs heat from a heat source (16, 53) outside of the sorption cycle and thus expels the refrigerant,
Cutting means for a lawnmower machine, configured for cutting grass and mulching, comprising a first cutting portion and a second cutting portion that extend on opposite sides with respect to an intermediate zone for connecting to a rotating shaft of said lawnmower machine, that is suitable for rotating said cutting means around a rotation axis (X R), wherein said first cutting portion and said second cutting portion are configured as a bar having a circular shaped cross-section or having a prismatic shape with a regular polygon shaped cross-section, and comprise respectively protrusions or more edge zones, for cutting and chopping up crop residue and subsequent release onto the land, said cross-section being so configured as to be inscribed in a circumference with a diameter that is at most equal to 20 mm CHARACTERISED IN THAT said first cutting portion and said second cutting portion extend along a longitudinal axis (A L), toothed coupling means being further included configured for transmitting to said first cutting portion and/or to said second cutting portion also a rotation around said longitudinal axis (A L).
A turbine engine component comprising a morphing aerodynamic control surface geometry comprising: a control surface having an articulated portion comprising a flexible skin coupled at an exterior of said articulated portion, said flexible skin comprising opposed interlocking elements sandwiched within a flexible polymer coupled to said interlocking elements, wherein said flexible skin is configured compliant responsive to an articulation of said articulated portion, wherein said articulated portion is part of the gas turbine engine component selected from the group consisting of a variable geometry splitter, gas flow path, a static engine component, a variable inlet guide vane and an adaptive flap, wherein said interlocking elements comprise at least one upper element and at least one lower element opposite said at least one upper element, and wherein said at least one upper element comprises an upper element exterior surface and an upper element interior surface having a feature opposite said upper element exterior surface, said at least one lower element comprises a lower element exterior surface and a lower element interior surface with a feature opposite said lower element exterior surface, and said upper element interior feature is configured to interlock with the lower element interior feature, characterised in that: said upper element interior feature comprises a peg extending out of a portion of said upper element interior surface and said lower element interior feature comprises a receiver formed in said lower element interior surface. a control surface having an articulated portion comprising a flexible skin coupled at an exterior of said articulated portion, said flexible skin comprising opposed interlocking elements sandwiched within a flexible polymer coupled to said interlocking elements, wherein said flexible skin is configured compliant responsive to an articulation of said articulated portion, wherein said articulated portion is part of the gas turbine engine component selected from the group consisting of a variable geometry splitter, gas flow path, a static engine component, a variable inlet guide vane and an adaptive flap, wherein said interlocking elements comprise at least one upper element and at least one lower element opposite said at least one upper element, and wherein said at least one upper element comprises an upper element exterior surface and an upper element interior surface having a feature opposite said upper element exterior surface, said at least one lower element comprises a lower element exterior surface and a lower element interior surface with a feature opposite said lower element exterior surface, and said upper element interior feature is configured to interlock with the lower element interior feature, characterised in that: said upper element interior feature comprises a peg extending out of a portion of said upper element interior surface and said lower element interior feature comprises a receiver formed in said lower element interior surface.
Kit for the preparation of a self-levelling screed or overlayment, characterized in that it comprises: - an inorganic component which is a self-levelling mortar in the powder form comprising one or more additives, at least one of which is a rheological additive of plasticizer and/or superplasticizer type, the amount of additives being between 0.01 and 20% by weight, with respect to the weight of mortar, and - from 0.1 to 15% by weight, with respect to the inorganic component, preferably from 0.1 to 10% by weight, of an organic component which is a liquid photocurable composition. - an inorganic component which is a self-levelling mortar in the powder form comprising one or more additives, at least one of which is a rheological additive of plasticizer and/or superplasticizer type, the amount of additives being between 0.01 and 20% by weight, with respect to the weight of mortar, and - from 0.1 to 15% by weight, with respect to the inorganic component, preferably from 0.1 to 10% by weight, of an organic component which is a liquid photocurable composition.
Bearing comprising a lubrication seal for providing a lubrication barrier to confine lubrication in the bearing, the bearing further comprising an inner bearing ring (17;25) and an outer bearing ring (16;23), one bearing ring being rotatable relative to the other, the lubrication seal comprising a support ring, a first seal ring and a second seal ring mounted in the support ring, which seal rings are suitable for forming the lubrication barrier with a sealing surface (28,29) and which support ring is displaceable from a first sealing position in which the first seal ring forms the lubrication barrier with a first sealing area and the second seal ring does not engage the sealing surface to a second sealing position in which the second seal ring forms the lubrication barrier, characterised in that the sealing surface comprises a second sealing area that only cooperates with the second seal ring after the support ring is displaced into the second sealing position, in that the support ring is coupled to one of the bearing rings, the sealing surfaces (28, 29) being on the other bearing ring, and in that the second sealing area is at the side of the lubrication barrier nearest to a bearing roller or bearing ball of the bearing when the support ring is in the first sealing position.
An adhesive composition comprising a) at least one isocyanate-terminated urethane prepolymer, b) at least one mercaptosilane, c) at least one polyisocyanate compound with functionality more than 2, d) one or more catalysts for the reaction of isocyanate moieties and hydroxyl groups, and e) carbon black filler.
A shim (1, 2), comprising at least: - a first sheet (3, 4) made up of a polymer material and having a first predetermined thickness that adheres to a first planar face of the shim so as to be able to be peeled without tearing; - a second sheet (5, 6) made up of a polymer material and having a second predetermined thickness that adheres to a second planar face of the shim opposite the first planar face so as to be able to be peeled without tearing; wherein the second sheet (5, 6) includes at least one physical characteristic other than the thickness that is different from that of the first sheet (3, 4), characterized in that said physical characteristic, uniformly different from the first sheet (3, 4), comprises a metallization of the polymer material so as to reflect the light. - a first sheet (3, 4) made up of a polymer material and having a first predetermined thickness that adheres to a first planar face of the shim so as to be able to be peeled without tearing; - a second sheet (5, 6) made up of a polymer material and having a second predetermined thickness that adheres to a second planar face of the shim opposite the first planar face so as to be able to be peeled without tearing; wherein the second sheet (5, 6) includes at least one physical characteristic other than the thickness that is different from that of the first sheet (3, 4), characterized in that said physical characteristic, uniformly different from the first sheet (3, 4), comprises a metallization of the polymer material so as to reflect the light.
A lighting unit comprising a source of blue light, a source of green light, a first source of red light comprising a first red luminescent material, configured to provide red light with a broad band spectral light distribution, and a second source of red light comprising a second red luminescent material, configured to provide red light with a spectral light distribution comprising one or more red emission lines.
A combination comprising a first immune checkpoint inhibitor and an IRM compound for use in the treatment of a tumor; wherein the IRM compound is N-(4-{[4-amino-2-butyl-1 H -imidazo[4,5- c]quinolin-1-yl]oxy}butyl)octadecanamide, or a pharmaceutically acceptable salt thereof, and wherein the immune checkpoint inhibitor compound is (i) a CTLA-4 receptor antibody or a fragment thereof or (ii) an anti-PD-L1 antibody or a fragment thereof.
A data acquisition means to be used with a drug delivery device for continuously acquiring information about operation of the device during the lifetime of the device and for indicating the information about the operation of the device to a user, comprising - a detector unit having a sensor element, said sensor element is configured to detect an actuation action to be performed on an actuator member of the drug delivery device in order to dispense at least a portion of a drug contained within the drug delivery device, and a push-button configured to exert said actuation action on said sensor element by pressing said push-button, wherein said sensor element is configured to detect said actuation action as pressing the push-button as part of said actuation action; and - an electronic subassembly having a power source, said electronic subassembly being connected to the sensor element and to the power source, wherein the electronic subassembly is configured to store at least a piece of information related to the detected actuation action, characterized in that the electronic subassembly is further configured to transmit signal(s) related to said piece(s) of information to the user, the at least one signal being in compliance with an actual charge level of the power source and changing as the charge level of said power source changes. - a detector unit having a sensor element, said sensor element is configured to detect an actuation action to be performed on an actuator member of the drug delivery device in order to dispense at least a portion of a drug contained within the drug delivery device, and a push-button configured to exert said actuation action on said sensor element by pressing said push-button, wherein said sensor element is configured to detect said actuation action as pressing the push-button as part of said actuation action; and - an electronic subassembly having a power source, said electronic subassembly being connected to the sensor element and to the power source, wherein the electronic subassembly is configured to store at least a piece of information related to the detected actuation action,
A method of detecting a fusion gene comprising a ROS1 kinase region, or a fusion protein encoded by the fusion gene, characterized by comprising the step of: detecting the presence of a polynucleotide encoding a polypeptide which is a fusion protein of SDC4 with ROS1, or the presence of the polypeptide, in a specimen obtained from a subject, wherein said polynucleotide is selected from the group consisting of: (i) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 2 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, (ii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, and (iii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 34 to the stop codon of exon 43 of the ROS1 gene. detecting the presence of a polynucleotide encoding a polypeptide which is a fusion protein of SDC4 with ROS1, or the presence of the polypeptide, in a specimen obtained from a subject, wherein said polynucleotide is selected from the group consisting of: (i) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 2 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, (ii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, and (iii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 34 to the stop codon of exon 43 of the ROS1 gene. (i) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 2 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, (ii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 32 to the stop codon of exon 43 of the ROS1 gene, and (iii) a polynucleotide consisting of a nucleotide sequence from the initiation codon ATG to exon 4 of the SDC4 gene and a nucleotide sequence from exon 34 to the stop codon of exon 43 of the ROS1 gene.
Method for producing a coffee beverage in a brewing apparatus of a coffee machine, wherein the brewing apparatus comprises a brewing chamber for receiving ground coffee and the brewing chamber has a brewing water inlet and a chamber outlet, wherein the coffee machine has a cream valve which is pre-tensioned in the closure direction by means of an automatic mechanical restoring device and which closes the chamber outlet in its closed position, wherein the method comprises the following process steps: a) supplying brewing water to the brewing water inlet of the brewing chamber at a first volume flow rate different from zero during a first period of time of a first brewing phase (a); and b) at least intermittently supplying brewing water to the brewing water inlet at a second and/or third volume flow rate different from zero during a period of time immediately after the first period of time, wherein the second and/or the third volume flow rate is or are different from the first volume flow rate and wherein the second and/or the third volume flow rate is or are selected in such a manner that the cream valve opens during the period of time immediately after the first period of time, characterised in that the second volume flow rate and/or the third volume flow rate is or are lower than the first volume flow rate. a) supplying brewing water to the brewing water inlet of the brewing chamber at a first volume flow rate different from zero during a first period of time of a first brewing phase (a); and b) at least intermittently supplying brewing water to the brewing water inlet at a second and/or third volume flow rate different from zero during a period of time immediately after the first period of time, wherein the second and/or the third volume flow rate is or are different from the first volume flow rate and wherein the second and/or the third volume flow rate is or are selected in such a manner that the cream valve opens during the period of time immediately after the first period of time,