A medical imaging system (100, 300) comprising: - a memory storing machine executable instructions: - a processor configured for controlling the medical imaging system, wherein execution of the machine executable instructions by the processor causes the processor to: - receive multiple diffusion weighted images of a subject, wherein the multiple diffusion weighted images each have an assigned b-value representing the diffusion weighting strength, wherein the multiple diffusion weighted images each have an assigned diffusion weighting direction, wherein for a region of interest there is at least one corresponding voxel in each of the multiple diffusion weighted images; - construct a set of equations for each of the at least one corresponding voxel, wherein the set of equations is constructed from an apparent diffusion equation for the assigned diffusion weighting direction of each of the multiple diffusion weighted images; characterized in that the execution of the machine executable instructions further causes the processor to - solve the set of equations for each voxel for a bo-value representing zero diffusion weighting as an optimization; and - construct a bo image using the bo value for each voxel, where the bo-value corresponds to image intensity at no diffusion weighting. - a memory storing machine executable instructions: - a processor configured for controlling the medical imaging system, wherein execution of the machine executable instructions by the processor causes the processor to: - receive multiple diffusion weighted images of a subject, wherein the multiple diffusion weighted images each have an assigned b-value representing the diffusion weighting strength, wherein the multiple diffusion weighted images each have an assigned diffusion weighting direction, wherein for a region of interest there is at least one corresponding voxel in each of the multiple diffusion weighted images; - construct a set of equations for each of the at least one corresponding voxel, wherein the set of equations is constructed from an apparent diffusion equation for the assigned diffusion weighting direction of each of the multiple diffusion weighted images; characterized in that the execution of the machine executable instructions further causes the processor to - solve the set of equations for each voxel for a bo-value representing zero diffusion weighting as an optimization; and - construct a bo image using the bo value for each voxel, where the bo-value corresponds to image intensity at no diffusion weighting. - receive multiple diffusion weighted images of a subject, wherein the multiple diffusion weighted images each have an assigned b-value representing the diffusion weighting strength, wherein the multiple diffusion weighted images each have an assigned diffusion weighting direction, wherein for a region of interest there is at least one corresponding voxel in each of the multiple diffusion weighted images; - construct a set of equations for each of the at least one corresponding voxel, wherein the set of equations is constructed from an apparent diffusion equation for the assigned diffusion weighting direction of each of the multiple diffusion weighted images; characterized in that the execution of the machine executable instructions further causes the processor to - solve the set of equations for each voxel for a bo-value representing zero diffusion weighting as an optimization; and - construct a bo image using the bo value for each voxel, where the bo-value corresponds to image intensity at no diffusion weighting.