A surgical clip applying apparatus, comprising: a housing; a drive mechanism including a support structure and a movable portion movably disposed in the housing, the movable portion including a shuttle, a first actuating tube, a second actuating tube, a first coupling member and a second coupling member; the shuttle defining an opening, wherein the first actuating tube is movably disposed within the opening; the first actuating tube including a proximal end portion and a distal end portion and defining a lumen, the second actuating tube being movably disposed within the lumen; the proximal end portion of the first actuating tube being movably disposed in an opening defined by the support structure; the distal end portion being configured to selectively engage the first coupling member and the second coupling member; an actuator coupled to the shuttle of the drive mechanism, the actuator configured to be moved between a first position relative to the housing and a second position relative to the housing to move the shuttle -between a proximal position and a distal position, the shuttle selectively moving at least one of the first actuating tube or the second actuating tube as the shuttle is moved between the proximal position and the distal position; and a cartridge assembly removably coupled to the housing, the cartridge assembly including a first member, a second member, and a clamp mechanism, the first member of the cartridge assembly removably coupled to the first coupling member of the drive mechanism such that movement of the first actuating tube moves-the first member of the cartridge assembly relative to the clamp mechanism to advance a surgical clip included in the cartridge assembly in a distal direction, the second member of the cartridge assembly removably coupled to the second coupling member such that movement of the second actuating tube moves-the second member of the cartridge assembly relative to the clamp mechanism, the clamp mechanism configured to be transitioned from a first configuration to a second configuration when the second member of the cartridge assembly is moved relative to the clamp mechanism, the clamp mechanism configured to clamp the surgical clip when in the second configuration. a housing; a drive mechanism including a support structure and a movable portion movably disposed in the housing, the movable portion including a shuttle, a first actuating tube, a second actuating tube, a first coupling member and a second coupling member; the shuttle defining an opening, wherein the first actuating tube is movably disposed within the opening; the first actuating tube including a proximal end portion and a distal end portion and defining a lumen, the second actuating tube being movably disposed within the lumen; the proximal end portion of the first actuating tube being movably disposed in an opening defined by the support structure; the distal end portion being configured to selectively engage the first coupling member and the second coupling member; an actuator coupled to the shuttle of the drive mechanism, the actuator configured to be moved between a first position relative to the housing and a second position relative to the housing to move the shuttle -between a proximal position and a distal position, the shuttle selectively moving at least one of the first actuating tube or the second actuating tube as the shuttle is moved between the proximal position and the distal position; and a cartridge assembly removably coupled to the housing, the cartridge assembly including a first member, a second member, and a clamp mechanism, the first member of the cartridge assembly removably coupled to the first coupling member of the drive mechanism such that movement of the first actuating tube moves-the first member of the cartridge assembly relative to the clamp mechanism to advance a surgical clip included in the cartridge assembly in a distal direction, the second member of the cartridge assembly removably coupled to the second coupling member such that movement of the second actuating tube moves-the second member of the cartridge assembly relative to the clamp mechanism, the clamp mechanism configured to be transitioned from a first configuration to a second configuration when the second member of the cartridge assembly is moved relative to the clamp mechanism, the clamp mechanism configured to clamp the surgical clip when in the second configuration.