A method for processing an initial image formed by a set of points defining a n -hyperpatch in a n -dimensional space, n being an integer greater than or equal to two, each point being associated with a numerical value, the initial image being a microscopy image comprising a set of drops detaching from the noise, the method comprising: - a step of constructing a thresholded image, in which the value of each point of the thresholded image takes on the zero value if the value of the corresponding point in the initial image is less than a predetermined threshold, and takes on the value of the corresponding point in the initial image otherwise, and - a step of enriching the thresholded image resulting in an enriched image, said step comprising: ∘ a sub-step of decomposing the thresholded image into one or more elementary sub-image(s), each elementary sub-image comprising all of the drops of the thresholded image corresponding to a class of drops defined by a predetermined sorting criterion, ∘ a sub-step of determining the centers of the drops, in which, in each of the elementary sub-images, the center of each drop is determined, ∘ a sub-step of constructing so-called "idealized" sub-images, in which one idealized sub-image is constructed for each elementary sub-image, each idealized sub-image comprising an idealized drop of the considered class of drops generated at the center of each drop of the corresponding elementary sub-image, each idealized drop integrating information relating to the physics of an imaged sample, the idealized drops being obtained by simulating a perfect image or based on one or more averaged reference experimental drop(s), ∘ a sub-step of merging the idealized sub-images, in which the different idealized sub-images are merged to form an idealized image, and ∘ a sub-step of constructing the enriched image, in which the idealized image is merged with the thresholded image to form the enriched image. - a step of constructing a thresholded image, in which the value of each point of the thresholded image takes on the zero value if the value of the corresponding point in the initial image is less than a predetermined threshold, and takes on the value of the corresponding point in the initial image otherwise, and - a step of enriching the thresholded image resulting in an enriched image, said step comprising: ∘ a sub-step of decomposing the thresholded image into one or more elementary sub-image(s), each elementary sub-image comprising all of the drops of the thresholded image corresponding to a class of drops defined by a predetermined sorting criterion, ∘ a sub-step of determining the centers of the drops, in which, in each of the elementary sub-images, the center of each drop is determined, ∘ a sub-step of constructing so-called "idealized" sub-images, in which one idealized sub-image is constructed for each elementary sub-image, each idealized sub-image comprising an idealized drop of the considered class of drops generated at the center of each drop of the corresponding elementary sub-image, each idealized drop integrating information relating to the physics of an imaged sample, the idealized drops being obtained by simulating a perfect image or based on one or more averaged reference experimental drop(s), ∘ a sub-step of merging the idealized sub-images, in which the different idealized sub-images are merged to form an idealized image, and ∘ a sub-step of constructing the enriched image, in which the idealized image is merged with the thresholded image to form the enriched image. ∘ a sub-step of decomposing the thresholded image into one or more elementary sub-image(s), each elementary sub-image comprising all of the drops of the thresholded image corresponding to a class of drops defined by a predetermined sorting criterion, ∘ a sub-step of determining the centers of the drops, in which, in each of the elementary sub-images, the center of each drop is determined, ∘ a sub-step of constructing so-called "idealized" sub-images, in which one idealized sub-image is constructed for each elementary sub-image, each idealized sub-image comprising an idealized drop of the considered class of drops generated at the center of each drop of the corresponding elementary sub-image, each idealized drop integrating information relating to the physics of an imaged sample, the idealized drops being obtained by simulating a perfect image or based on one or more averaged reference experimental drop(s), ∘ a sub-step of merging the idealized sub-images, in which the different idealized sub-images are merged to form an idealized image, and ∘ a sub-step of constructing the enriched image, in which the idealized image is merged with the thresholded image to form the enriched image.