mhurhangee/ep-ind-claims huggingface dataset:
A method for the determination of the binding affinity of a drug to its target comprising the following step: - determining the fraction of free drug or free target in a sample comprising drug, target and non-covalent drug-target-complexes in the drug concentration range at a constant target concentration where the free drug fraction stays constant, by determining based on the result of an immunoassay the fraction of free drug in a sample comprising drug, target and drug-target-complexes for at least two different drug:target ratios in the sample, and if the determined fraction of free drug is not comparable for all used drug:target ratios then the drug:target ratio in the sample is lowered and the sample is re-analyzed by the same immunoassay, or determining based on the result of an immunoassay the fraction of free target in a sample comprising drug, target and drug-target-complexes for at least two different drug:target ratios in the sample, and if the determined fraction of free target is not comparable for all used drug:target ratios then the drug:target ratio in the sample is increased and the sample is re-analyzed by the same immunoassay, and - calculating based on the fraction of free drug or calculating based on the fraction of free target determined in the previous step the binding affinity for the drug to its target, wherein comparable denotes a relative difference (%Diff) of two determined values of less than 100 % calculated with the following formula: % Diff = highest value − lowest value / arithmetic mean of the values, wherein for the calculation of the K D value the following equation is used: K D = free drug fraction * target concentration nM / 1 − free drug fraction. - determining the fraction of free drug or free target in a sample comprising drug, target and non-covalent drug-target-complexes in the drug concentration range at a constant target concentration where the free drug fraction stays constant, by determining based on the result of an immunoassay the fraction of free drug in a sample comprising drug, target and drug-target-complexes for at least two different drug:target ratios in the sample, and if the determined fraction of free drug is not comparable for all used drug:target ratios then the drug:target ratio in the sample is lowered and the sample is re-analyzed by the same immunoassay, or determining based on the result of an immunoassay the fraction of free target in a sample comprising drug, target and drug-target-complexes for at least two different drug:target ratios in the sample, and if the determined fraction of free target is not comparable for all used drug:target ratios then the drug:target ratio in the sample is increased and the sample is re-analyzed by the same immunoassay, and - calculating based on the fraction of free drug or calculating based on the fraction of free target determined in the previous step the binding affinity for the drug to its target,
A person couch for carrying out radiological medical imaging examinations by means of x-rays, tomography, magnetic resonance imaging and other imaging procedures in which a person is photographed in a lying position in layers and other images are being made, equipped with foot rests for positioning the soles of the feet as when standing, on vertical bearing surfaces in the same plane, which are adjustable in such a way that they always have the same distance from the longitudinal central axis of the couch and which enable the feet to stand obliquely in the foot rest in accordance with the individual foot position of the patient, and with a detection device for optical, laser-optical mechanical or electromechanical measurement of the patient's body or specific points on the patient's body, for detecting the positions of at least the knee joints, the hip joint, the pelvic bone, the shoulders and the head, wherein the couch is furthermore equipped with pressure sensors, for measuring the local support weights of the various resting body points, for reproducible detection of the position of the skeleton with respect to its central axis and for possible rotations of the shoulder and/or hip, and for reproducible detection of the position of the skeleton with respect to its central axis and of any rotations of the shoulder and/or hip.
A method of manufacturing a carbon dioxide adsorbent, comprising: providing ironmaking sludge; mixing the ironmaking sludge and a binder; manufacturing a pellet by injecting ammonia into the ironmaking sludge mixed with the binder; and drying the pellet. providing ironmaking sludge; mixing the ironmaking sludge and a binder; manufacturing a pellet by injecting ammonia into the ironmaking sludge mixed with the binder; and drying the pellet.
A dosing device for cleaning agents comprising a vessel for cleaning liquid and a dosing volume detachably arranged thereon, characterized in that for engagement the dosing volume exhibits engagement means dimensioned so as to be engaged by a mop holder and it is pivotable about a pivot axis spaced apart from the engagement means from a horizontal starting position into the vessel.
Exhaust-gas turbocharger having an exhaust-gas turbine with a turbine wheel, having a fresh-air compressor with a compressor wheel, and having a bearing receptacle, - wherein the turbine wheel and the compressor wheel are arranged on a common rotor shaft and thus form a turbo rotor, and the rotor shaft 8 is rotatably mounted in the bearing housing by means of at least one radial bearing (105/106) in the form of a floating-bushing bearing, and - wherein the at least one radial bearing (105/106) has a floating bushing body which is formed in the manner of a hollow cylinder with an internal diameter (D I) which receives the rotor shaft and with an external diameter (D A) by which the floating bushing body is received in a bearing receptacle, wherein an inner lubrication gap is formed between the rotor shaft and the internal diameter (D I) of the floating bushing body and an outer lubrication gap is formed between the bearing receptacle and the outer diameter (D A), and wherein the floating bushing body is provided with a defined imbalance (3, 4, 5, 6, 7, E) with respect to its axis of rotation, which imbalance counteracts, in stabilizing fashion, an imbalance of the turbo rotor during operation, characterized in that the defined imbalance of the floating bushing body, expressed as an eccentricity, lies in a range between 20% to 30% of a bearing play formed by the inner lubrication gap. - wherein the turbine wheel and the compressor wheel are arranged on a common rotor shaft and thus form a turbo rotor, and the rotor shaft 8 is rotatably mounted in the bearing housing by means of at least one radial bearing (105/106) in the form of a floating-bushing bearing, and - wherein the at least one radial bearing (105/106) has a floating bushing body which is formed in the manner of a hollow cylinder with an internal diameter (D I) which receives the rotor shaft and with an external diameter (D A) by which the floating bushing body is received in a bearing receptacle, wherein an inner lubrication gap is formed between the rotor shaft and the internal diameter (D I) of the floating bushing body and an outer lubrication gap is formed between the bearing receptacle and the outer diameter (D A), and
An acoustic panel for a turbomachine, in particular for an aircraft, comprising vibrating masses and walls forming cavities, said walls comprising two skins (12, 14) that are substantially parallel and between which are located and extend the cavities forming Helmholtz resonator, one of said skins being perforated by orifices opening into said cavities and forming necks of said resonators, the vibrating masses being provided in at least some of said cavities and connected to the cavities walls, characterized in that said vibrating masses are connected to said cavity walls by elastic means housed in said cavities.
A dental implant extending along a first longitudinal axis (l-I) between a proximal end and a distal end, comprising: - a proximal endosseous portion intended to be embedded in the jawbone of the patient, - a distal implant portion continuing the proximal endosseous portion away from the proximal end and intended to protrude from the jawbone of the patient, said distal implant portion comprising an outer surface having a roughness Ra of less than or equal to 0.2 μm, - an inner connection recess extending from the distal end and in the direction of the proximal end, in which: - the distal implant portion extends by a height along the first longitudinal axis (l-I) in the direction of the distal end from a base to a top, widening from the base to the top in the direction away from the first longitudinal axis (l-I), - the height by which the distal implant portion extends from its base to its top is between 1.2 mm and 1.5 mm, characterized in that: - the base has a diameter smaller than a diameter of the adjacent proximal endosseous portion, so as to form a first annular groove, - the endosseous portion is provided with an external thread which extends in the direction of the distal end of the dental implant and is interrupted before the first annular groove, so that the proximal endosseous portion starts, away from the distal implant portion by a cylindrical portion. - a proximal endosseous portion intended to be embedded in the jawbone of the patient, - a distal implant portion continuing the proximal endosseous portion away from the proximal end and intended to protrude from the jawbone of the patient, said distal implant portion comprising an outer surface having a roughness Ra of less than or equal to 0.2 μm, - an inner connection recess extending from the distal end and in the direction of the proximal end, - the distal implant portion extends by a height along the first longitudinal axis (l-I) in the direction of the distal end from a base to a top, widening from the base to the top in the direction away from the first longitudinal axis (l-I), - the height by which the distal implant portion extends from its base to its top is between 1.2 mm and 1.5 mm, - the base has a diameter smaller than a diameter of the adjacent proximal endosseous portion, so as to form a first annular groove, - the endosseous portion is provided with an external thread which extends in the direction of the distal end of the dental implant and is interrupted before the first annular groove, so that the proximal endosseous portion starts, away from the distal implant portion by a cylindrical portion.
An aerosol delivery device comprising: a cartridge that is equipped with a heating element and an authentication device, and contains an aerosol precursor composition; and a control body coupled with the cartridge and configured to exchange authentication signals with the authentication device to authenticate the cartridge for use with the control body, and only in instances in which the cartridge is authenticated, direct power to the heating element to activate and vaporize components of the aerosol precursor composition, wherein the control body and the cartridge include respectively a two-wire electrical connector and a corresponding two-wire electrical connector coupled with one another, and across which the authentication signals are exchanged and the power is directed, and wherein the control body and the cartridge further include respectively a first switching circuit and a second switching circuit, the first switching circuit being coupled with the second switching circuit to form switching circuitry configured to manage the authentication signals and the power across the two-wire electrical connector. a cartridge that is equipped with a heating element and an authentication device, and contains an aerosol precursor composition; and a control body coupled with the cartridge and configured to exchange authentication signals with the authentication device to authenticate the cartridge for use with the control body, and only in instances in which the cartridge is authenticated, direct power to the heating element to activate and vaporize components of the aerosol precursor composition, wherein the control body and the cartridge include respectively a two-wire electrical connector and a corresponding two-wire electrical connector coupled with one another, and across which the authentication signals are exchanged and the power is directed, and wherein the control body and the cartridge further include respectively a first switching circuit and a second switching circuit, the first switching circuit being coupled with the second switching circuit to form switching circuitry configured to manage the authentication signals and the power across the two-wire electrical connector.
A field rotor of a superconducting rotating machine comprising: a rotation shaft; a supply shaft that supplies a refrigerant to the rotation shaft at one end of the rotation shaft; an input/output shaft provided at the other end of the rotation shaft so as to integrally rotate with the rotation shaft; and a superconducting coil held on a circumferential surface of the rotation shaft to be cooled by the refrigerant, wherein the supply shaft and the input/output shaft are fixed to each other so as to rotate integrally with each other, characterised in that the rotation shaft and the supply shaft are at least partly brought in contact with each other in order to allow the rotation shaft to be supported by the supply shaft and in order to be slidably fitted to each other in a circumferential direction of the rotation shaft and in an axial direction of the rotation shaft, and in that the supply shaft and the rotation shaft are disposed such that one of them having relatively a large thermal contraction amount in a diameter direction upon a change from a room-temperature state to a cool-temperature state is located at the outer circumference of the other one having a relatively small thermal contraction amount. a rotation shaft; a supply shaft that supplies a refrigerant to the rotation shaft at one end of the rotation shaft; an input/output shaft provided at the other end of the rotation shaft so as to integrally rotate with the rotation shaft; and a superconducting coil held on a circumferential surface of the rotation shaft to be cooled by the refrigerant, wherein the supply shaft and the input/output shaft are fixed to each other so as to rotate integrally with each other,
Use of a recombinant Ganoderma Lucidum Immunoregulatory Protein (rLZ-8) encoded by a nucleotide sequence SEQ ID NO 1 in preparation of medicaments for treating a cancer selected from the group consisting of leukemia, ascites tumor and liver cancer.
A coated detergent particle having perpendicular dimensions x, y and z, wherein x is from 0.5 to 2 mm, y is from 2 to 8mm, and z is from 2 to 8 mm, wherein the particle comprises: (i) from 20 to 39 wt % of a surfactant selected from: anionic and non-ionic surfactants; (ii) from 10 to 40 wt % of inorganic salts selected from: sodium carbonate and/or sodium sulphate of which at least 5 wt % of the inorganic salt is sodium carbonate; and, (iii) from 0.0001 to 0.5 wt % pigment, wherein the pigment is selected: from organic and inorganic pigments, and wherein the inorganic salts and the pigment are present on the detergent particle as a coating and the surfactant is present as a core. (i) from 20 to 39 wt % of a surfactant selected from: anionic and non-ionic surfactants; (ii) from 10 to 40 wt % of inorganic salts selected from: sodium carbonate and/or sodium sulphate of which at least 5 wt % of the inorganic salt is sodium carbonate; and, (iii) from 0.0001 to 0.5 wt % pigment, wherein the pigment is selected: from organic and inorganic pigments, and
Refrigerating circuit for circulating a refrigerant in a predetermined flow direction through at least one removable compressor (2, 2', 2"), wherein an upstream-side shut-off valve (3, 3', 3") is provided upstream of the compressor (2, 2', 2") and a downstream-side non-return valve (4, 4', 4") which is configured to open automatically as soon as the compressor (2, 2', 2") reaches a pressure that is identical to the pressure within the pressure line of the refrigeration circuit is provided in a pressure line downstream of the compressor (2, 2', 2"), characterized in that the downstream-side valve (4, 4', 4") is lockable in its open state.
A method for managing an embedded universal integrated circuit card, eUICC, wherein the eUICC is installed in a terminal, a profile is installed in the eUICC, the profile is locked according to a policy rule, and the method comprises: determining, by the terminal, identifier information and verification information of the profile that needs to be unlocked, wherein the identifier information of the profile is used to identify the profile installed in the terminal; sending, by the terminal, a first unlock message to the eUICC, wherein the first unlock message carries the identifier information and the verification information of the profile, and the first unlock message is used to instruct the eUICC to determine the profile, and unlock the profile according to the policy rule after verification performed according to the verification information succeeds; characterized by unlocking, by the eUICC installed in the terminal, the profile by disabling the policy rule. determining, by the terminal, identifier information and verification information of the profile that needs to be unlocked, wherein the identifier information of the profile is used to identify the profile installed in the terminal; sending, by the terminal, a first unlock message to the eUICC, wherein the first unlock message carries the identifier information and the verification information of the profile, and the first unlock message is used to instruct the eUICC to determine the profile, and unlock the profile according to the policy rule after verification performed according to the verification information succeeds; characterized by unlocking, by the eUICC installed in the terminal, the profile by disabling the policy rule.
A method of quantifying an effect of an agent on myelination of neuronal cells, the method comprising: (a) ex-vivo differentiating embryonic stem cells into oligodendrocyte precursor cells (OPCs) expressing Hes5, oligl and olig2; (b) freezing and thawing said OPCs, wherein thawing is performed in a medium comprising growth factors; (c) after thawing, culturing said OPCs for at least one day in the absence of growth factors; (d) contacting said OPCs with the agent; and (e) quantifying at least one marker of myelination in said OPCs, thereby quantifying the effect of the agent on myelination of neuronal cells. (a) ex-vivo differentiating embryonic stem cells into oligodendrocyte precursor cells (OPCs) expressing Hes5, oligl and olig2; (b) freezing and thawing said OPCs, wherein thawing is performed in a medium comprising growth factors; (c) after thawing, culturing said OPCs for at least one day in the absence of growth factors; (d) contacting said OPCs with the agent; and (e) quantifying at least one marker of myelination in said OPCs, thereby quantifying the effect of the agent on myelination of neuronal cells.
A suturing device for use with a suturing needle, the device comprising: a body having a proximal end and a distal end; a first clamp near the distal end of the body; a second clamp near the distal end of the body; a handle; and a linkage coupling the handle to the first and second clamps to effect movement of the first and second clamps, the handle being moveable from a first configuration to a second configuration and back to the first configuration so as to define an actuation cycle, wherein the handle is coupled to the first and second clamps by the linkage such that when the handle undergoes an actuation cycle the linkage effects movement of one of the first and second clamps between a grasping configuration and a displaced configuration and the other of the first and second clamps between a displaced configuration and a grasping configuration, each clamp grasping the needle at an associated grasping location in the grasping configuration and being laterally displaced from the long axis of the needle in the displaced configuration, the grasping locations being substantially fixed relative to the body. a body having a proximal end and a distal end; a first clamp near the distal end of the body; a second clamp near the distal end of the body; a handle; and a linkage coupling the handle to the first and second clamps to effect movement of the first and second clamps, the handle being moveable from a first configuration to a second configuration and back to the first configuration so as to define an actuation cycle, wherein the handle is coupled to the first and second clamps by the linkage such that when the handle undergoes an actuation cycle the linkage effects movement of one of the first and second clamps between a grasping configuration and a displaced configuration and the other of the first and second clamps between a displaced configuration and a grasping configuration, each clamp grasping the needle at an associated grasping location in the grasping configuration and being laterally displaced from the long axis of the needle in the displaced configuration, the grasping locations being substantially fixed relative to the body.
Apparatus for computing plural-network coverage data for connecting a mobile communication device to a communication network from among a plurality of communication networks serving an area, characterized in that the plurality of communication networks (330A-C) include communication networks of the same standard operated by a plurality of network operators, and the apparatus comprises: at least one input interface configured for acquiring current network-specific coverage data respectively from the plurality of communication networks (330A-C); and circuitry configured for combining the acquired current network-specific coverage data from the plurality of communication networks and for determining, based on the combination, plural-network coverage data indicating a local density of communication terminals. at least one input interface configured for acquiring current network-specific coverage data respectively from the plurality of communication networks (330A-C); and circuitry configured for combining the acquired current network-specific coverage data from the plurality of communication networks and for determining, based on the combination, plural-network coverage data indicating a local density of communication terminals.