A prosthetic mitral valve coaptation enhancement device for implanting at the native mitral valve region of a heart, the native mitral valve having a native annulus and native valve leaflets (72, 73), the prosthetic mitral valve coaptation enhancement device comprising: a main body consisting of a tubular stentframe and a valve element attached thereto, the main body comprising a length and a lumen being defined by a proximal end and a distal end, and configured for placement within the native valve region of the heart, the tubular stentframe being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state, wherein the main body has a sealing section and a valve-bearing section, the valve- bearing section carrying the valve element; characterized in that the shape of the sealing section of the main body, in the compressed state, has a form that is adapted to the coaptation zone of the native mitral valve during systole, and that in the sealing section of the main body, the radial rigidity of the tubular stentframe is lower than the radial rigidity of the valve-bearing section; and that the prosthetic mitral valve coaptation enhancement device further comprises at least one anchoring element, which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart, and that the tubular stentframe in the sealing section consists of a flexible structure such, that, in the compressed state, it conforms to the coaptation zone of the native mitral valve during systole, wherein the tubular stentframe, in the sealing section, has a flexibility and rigidity that is lower than the flexibility and rigidity of the valve-bearing section, and in that the prosthetic mitral valve coaptation enhancement device has a size enabling the sealing section being positionable at the level of the native mitral valve leaflets (72, 73) and the valve-bearing section being positionable distally in the left ventricle or proximally in the left atrium. a main body consisting of a tubular stentframe and a valve element attached thereto, the main body comprising a length and a lumen being defined by a proximal end and a distal end, and configured for placement within the native valve region of the heart, the tubular stentframe being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state, wherein the main body has a sealing section and a valve-bearing section, the valve- bearing section carrying the valve element; characterized in that the shape of the sealing section of the main body, in the compressed state, has a form that is adapted to the coaptation zone of the native mitral valve during systole, and that in the sealing section of the main body, the radial rigidity of the tubular stentframe is lower than the radial rigidity of the valve-bearing section; and that the prosthetic mitral valve coaptation enhancement device further comprises at least one anchoring element, which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart, and that the tubular stentframe in the sealing section consists of a flexible structure such, that, in the compressed state, it conforms to the coaptation zone of the native mitral valve during systole, wherein the tubular stentframe, in the sealing section, has a flexibility and rigidity that is lower than the flexibility and rigidity of the valve-bearing section, and in that the prosthetic mitral valve coaptation enhancement device has a size enabling the sealing section being positionable at the level of the native mitral valve leaflets (72, 73) and the valve-bearing section being positionable distally in the left ventricle or proximally in the left atrium.