mhurhangee/ep-ind-claims huggingface dataset:
A liquid-phase process for the production of Linaclotide, preferably in the form of the acetate salt, which comprises the following steps: a1) coupling a dipeptide Fragment B of formula Fmoc-Asn(Trt)-Pro-OH with a hexapeptide Fragment C of formula Fmoc-Ala-Cys[Ψ(Dmp,H)pro]-Thr(tBu)-Gly-Cys[Ψ(Dmp,H)pro]-Tyr(tBu)-OtBu to obtain the peptide; a2) coupling the peptide with an amino acid derivative of formula Fmoc-Cys(Trt)-OH in position 6 to obtain the peptide; a3) coupling the peptide with an amino acid derivative of formula Fmoc-Cys(SO 3 Na)-ONa in position 5 to obtain the peptide; a4) coupling the peptide with a tetrapeptide Fragment A of formula Fmoc-Cys(SO 3 Na)-Cys(SO 3 Na)-Glu(tBu)-Tyr(tBu)-OH to obtain the protected peptide of formula Fmoc-Cys(SO 3 Na)-Cys(SO 3 Na)-Glu(tBu)-Tyr(tBu)-Cys(SO 3 Na)-Cys(Trt)-Asn(Trt)-Pro-Ala-Cys[Ψ(Dmp,H)pro]-Thr(tBu)-Gly-Cys[Ψ(Dmp,H)pro]-Tyr(tBu)-OtBu; b) deprotecting compound by reaction with a secondary base and trifluoro acetic acid to obtain the intermediate of formula (VIII) H-Cys(SO 3 H)-Cys(SO 3 H)-Glu-Tyr-Cys(SO 3 H)-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH TFA salt; c) carrying out a non-oxidative cyclization on intermediate (VIII) to obtain crude Linaclotide; d) optionally, purifying the crude Linaclotide to obtain purified Linaclotide; e) optionally, salifying the purified Linaclotide with acetic acid to form the corresponding acetate salt. a1) coupling a dipeptide Fragment B of formula Fmoc-Asn(Trt)-Pro-OH with a hexapeptide Fragment C of formula Fmoc-Ala-Cys[Ψ(Dmp,H)pro]-Thr(tBu)-Gly-Cys[Ψ(Dmp,H)pro]-Tyr(tBu)-OtBu to obtain the peptide; a2) coupling the peptide with an amino acid derivative of formula Fmoc-Cys(Trt)-OH in position 6 to obtain the peptide; a3) coupling the peptide with an amino acid derivative of formula Fmoc-Cys(SO 3 Na)-ONa in position 5 to obtain the peptide; a4) coupling the peptide with a tetrapeptide Fragment A of formula Fmoc-Cys(SO 3 Na)-Cys(SO 3 Na)-Glu(tBu)-Tyr(tBu)-OH to obtain the protected peptide of formula Fmoc-Cys(SO 3 Na)-Cys(SO 3 Na)-Glu(tBu)-Tyr(tBu)-Cys(SO 3 Na)-Cys(Trt)-Asn(Trt)-Pro-Ala-Cys[Ψ(Dmp,H)pro]-Thr(tBu)-Gly-Cys[Ψ(Dmp,H)pro]-Tyr(tBu)-OtBu; b) deprotecting compound by reaction with a secondary base and trifluoro acetic acid to obtain the intermediate of formula (VIII) H-Cys(SO 3 H)-Cys(SO 3 H)-Glu-Tyr-Cys(SO 3 H)-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH TFA salt; c) carrying out a non-oxidative cyclization on intermediate (VIII) to obtain crude Linaclotide; d) optionally, purifying the crude Linaclotide to obtain purified Linaclotide; e) optionally, salifying the purified Linaclotide with acetic acid to form the corresponding acetate salt.
A plug connection for pipe or hose assemblies with a threaded body exhibiting a borehole for conducting a medium flowing through the pipe or hose assembly, and with a union nut screwed onto the threaded body for the locked retention of a pipe section inserted into the threaded body by means of a circlip that is supported against a locking surface arranged on the pipe section, and is located in a chamber of the union nut, wherein a floor surface of the chamber allocated to the circlip incorporates a stepped recess for holding the circlip, comprised of a first stage situated adjacent to the chamber and set up to accommodate the circlip during insertion of the pipe section, and a second stage adjoining the latter that secures the circlip so that it abuts in a locking manner against the locking surface of the inserted pipe section, characterized in that the union nut screwed onto the threaded body is retained on the threaded body secured against loss by means of a resiliently expandable snap ring arranged between the threaded body and union nut, and the union nut is arranged so that it can be twisted between an insertion position and locking position for the circlip due to the respective snap ring that engages into grooves (26, 27, 28) formed on the threaded body and union nut, and further that a stop for the union nut twisted into the locking position is situated on the threaded body, wherein the circlip lies in the first stage of the recess formed in the union nut in the insertion position of the union nut, while in the locking position of the union nut, the second stage of the recess overlaps the circlip and fixes the circlip in place so that it abuts the locking surface of the inserted pipe section in a locking manner.
A method of manufacturing a rechargeable power cell, said method comprising the steps of: applying a zinc negative electrode material to a first carrier sheet having first and second opposing and substantially planar surfaces such that a first electrode is formed; applying a nickel positive electrode material to a second carrier sheet having first and second opposing and substantially planar surfaces such that a second electrode is formed; disposing a plurality of separator sheets along the first planar surface of the first electrode, along the second planar surface of the first electrode, along the first planar surface of the second electrode, and along the second planar surface of the second electrode such that the first electrode and the second electrode are layered between the plurality of separator sheets to form a cell assembly; and winding the electrodes and sheets such that a cell assembly having a first end and a second end is formed and such that the first electrode, the second electrode, and the separator sheets are substantially co-parallel. applying a zinc negative electrode material to a first carrier sheet having first and second opposing and substantially planar surfaces such that a first electrode is formed; applying a nickel positive electrode material to a second carrier sheet having first and second opposing and substantially planar surfaces such that a second electrode is formed; disposing a plurality of separator sheets along the first planar surface of the first electrode, along the second planar surface of the first electrode, along the first planar surface of the second electrode, and along the second planar surface of the second electrode such that the first electrode and the second electrode are layered between the plurality of separator sheets to form a cell assembly; and winding the electrodes and sheets such that a cell assembly having a first end and a second end is formed and such that the first electrode, the second electrode, and the separator sheets are substantially co-parallel.
An anti-reflection coating comprising first to ninth layers laminated in this order on a substrate for having reflectance of 0.2% or less to light in a visible wavelength range of 390-720 nm, said second, fourth, sixth and eighth layers (22, 24, 26, 28) being high-refractive-index layers each formed by a high-refractive-index material having a refractive index of 2.21-2.70 to a helium d-line having a wavelength of 587.56 nm; said first, third, fifth and seventh layers (21, 23, 25, 27) being intermediate-refractive-index layers each formed by an intermediate-refractive-index material having a refractive index of 1.40 or more and less than 1.55 to said d-line; and said ninth layer being a low-refractive-index layer formed by a low-refractive-index material having a refractive index of 1.35 or more and less than 1.40 to said d-line.
A conveyor belt module comprising: a rigid link substrate molded of a low-friction plastic material and having hinge elements (20, 21) at opposite ends (16, 17) of the rigid link substrate for connecting hingedly with hinge elements of adjacent rigid link substrates, a load-bearing surface between the opposite ends (16, 17) of the rigid link substrate, and an array of thin teeth upstanding from the load-bearing surface, wherein each tooth has a base proximate the load-bearing surface and a distal tip end; characterised in that in comprises: a high-friction layer made of a resilient material molded atop the load-bearing surface of the rigid link substrate at a temperature sufficiently high and applied long enough to melt the distal tip ends of the teeth in contact with the resilient material without melting the bases of the teeth during the molding of the high-friction layer onto the rigid link substrate and to cause the melted distal tip ends to mix with the resilient material to retain the high-friction layer atop the load-bearing surface. a rigid link substrate molded of a low-friction plastic material and having hinge elements (20, 21) at opposite ends (16, 17) of the rigid link substrate for connecting hingedly with hinge elements of adjacent rigid link substrates, a load-bearing surface between the opposite ends (16, 17) of the rigid link substrate, and an array of thin teeth upstanding from the load-bearing surface, wherein each tooth has a base proximate the load-bearing surface and a distal tip end; characterised in that in comprises: a high-friction layer made of a resilient material molded atop the load-bearing surface of the rigid link substrate at a temperature sufficiently high and applied long enough to melt the distal tip ends of the teeth in contact with the resilient material without melting the bases of the teeth during the molding of the high-friction layer onto the rigid link substrate and to cause the melted distal tip ends to mix with the resilient material to retain the high-friction layer atop the load-bearing surface. a high-friction layer made of a resilient material molded atop the load-bearing surface of the rigid link substrate at a temperature sufficiently high and applied long enough to melt the distal tip ends of the teeth in contact with the resilient material without melting the bases of the teeth during the molding of the high-friction layer onto the rigid link substrate and to cause the melted distal tip ends to mix with the resilient material to retain the high-friction layer atop the load-bearing surface.
A low-melting point glass for a conductive paste for a solar battery having a silicon semiconductor substrate provided therein, which is characterized in that the low-melting-point glass has substantially no lead therein and is a SiO 2 -B 2 O 3 -ZnO-RO-R 2 O type lead-free low-melting-point glass that contains, by wt%, 2 to 10% of SiO 2, 19 to 29% of B 2 O 3, 0 to 10% of Al 2 O 3, 0 to 25% of ZnO, 20-50% of RO (total of at least one or more selected from MgO, CaO, SrO and BaO), and 10 to 17% of R 2 O (total of at least one or more selected from Li 2 O, Na 2 O, and K 2 O).
Shiftable twin gear for a twin-clutch gearbox, comprising a first gear body (102; 202) to be supported with respect to a shaft and a second gear body (104; 204), which gear bodies can be non-rotatably coupled to one another, wherein a bearing sleeve (106; 206) non-rotatably connected to the first gear body (102; 202) and having a first bearing region for the support of the second gear body (104; 204) is provided, characterised in that the bearing sleeve is produced as a separate component and press-fitted to the first gear body.
Box for electrical installations of recess-mounted type, installed by means of an attaching system of metallic clamping claws and metallic screws of the box in hollow walls or raised flooring, characterized in that the metallic screws of the metallic clamping claws have, in at least one section of their length, a coating (21, 22); and in that the box further comprises both longitudinal passages and corresponding lateral cavities that allow to turn a respective claw.
A method by a user equipment, UE, (11-15; 11-35) in a wireless communication system, the method comprising: receiving a first physical downlink shared channel, PDSCH, transmission and a second PDSCH transmission that are associated with a first transmission configuration indicator, TCI, state and a second TCl state, respectively, the first and second PDSCH transmissions carrying a same transport block, TB; characterised by: determining a first transport block size, TBS, of the first PDSCH transmission, wherein the determined first TBS is applied to a second TBS of the second PDSCH transmission; and identifying, corresponding to the same transport block, a first low-density parity-check, LDPC, base graph for the first PDSCH transmission based on the determined first TBS and a second LDPC base graph for the second PDSCH transmission based on the second TBS, wherein the first PDSCH transmission includes a lowest resource block among resource blocks allocated to a plurality of PDSCH transmissions including the first PDSCH transmission and the second PDSCH transmission. receiving a first physical downlink shared channel, PDSCH, transmission and a second PDSCH transmission that are associated with a first transmission configuration indicator, TCI, state and a second TCl state, respectively, the first and second PDSCH transmissions carrying a same transport block, TB; characterised by: determining a first transport block size, TBS, of the first PDSCH transmission, wherein the determined first TBS is applied to a second TBS of the second PDSCH transmission; and identifying, corresponding to the same transport block, a first low-density parity-check, LDPC, base graph for the first PDSCH transmission based on the determined first TBS and a second LDPC base graph for the second PDSCH transmission based on the second TBS, wherein the first PDSCH transmission includes a lowest resource block among resource blocks allocated to a plurality of PDSCH transmissions including the first PDSCH transmission and the second PDSCH transmission.
An isolated antibody or antigen-binding fragment thereof comprising a binding domain comprising a heavy chain variable region and a light chain variable region; wherein the VH comprises the amino acid sequence SEQ ID NO: 1, and wherein the VL comprises the amino acid sequence SEQ ID NO: 2.
A method for forming a coating (9, 11; 39, 41) on a limited site of a subject body (1, 21), comprising: applying one selected from the group of a compressed body of a powder of a metal and a sintered compressed body of a powder of a metal to a working electrode (7, 35); executing electric discharge deposition in a processing bath (5, 33) to deposit a coating (9, 39) from the working electrode (7, 35) on the subject body (1, 21) by applying the subject body as a workpiece of the electric discharge deposition and continuing the electric discharge deposition to make the coating (9,39) grow to form a buildup coating (11,41) under a discharge condition in that a peak current is 30A or less and a pulse width is 200μs or less so as to generate a fusion layer (13,43) of 3μm or more and 20μm or less in thickness at a boundary between the buildup coating (11,41) and the subject body (1,21); heating the subject body (1, 21) in one selected from the group of a vacuum, an air and an oxidizing atmosphere so as to densify the buildup coating (11, 41) or oxidizing the buildup coating (11, 41) at least in part to generate a solid lubricant substance (17, 47); and filling a solid lubricant material consisting essentially of one selected from the group of hBN, MoS 2, BaZrO 3 and Cr 2 O 3 in pores (15, 45) included in the buildup coating (11, 41) before the step of heating. applying one selected from the group of a compressed body of a powder of a metal and a sintered compressed body of a powder of a metal to a working electrode (7, 35); executing electric discharge deposition in a processing bath (5, 33) to deposit a coating (9, 39) from the working electrode (7, 35) on the subject body (1, 21) by applying the subject body as a workpiece of the electric discharge deposition and continuing the electric discharge deposition to make the coating (9,39) grow to form a buildup coating (11,41) under a discharge condition in that a peak current is 30A or less and a pulse width is 200μs or less so as to generate a fusion layer (13,43) of 3μm or more and 20μm or less in thickness at a boundary between the buildup coating (11,41) and the subject body (1,21); heating the subject body (1, 21) in one selected from the group of a vacuum, an air and an oxidizing atmosphere so as to densify the buildup coating (11, 41) or oxidizing the buildup coating (11, 41) at least in part to generate a solid lubricant substance (17, 47); and heating the subject body (1, 21) in one selected from the group of a vacuum, an air and an oxidizing atmosphere so as to densify the buildup coating (11, 41) or oxidizing the buildup coating (11, 41) at least in part to generate a solid lubricant substance (17, 47); and filling a solid lubricant material consisting essentially of one selected from the group of hBN, MoS 2, BaZrO 3 and Cr 2 O 3 in pores (15, 45) included in the buildup coating (11, 41) before the step of heating.
A marine lubricating oil comprising from 15 to 95 wt% of a Group III base stock having a KV100 of 4 to 12 cSt, 0.5 to 55 wt% of cobase stock having a KV100 of 29 to 1000 cSt, 0.1 to 2.0 wt% of a molydithiocarbamate friction modifier, 0.1 to 2.0 wt% of a zinc dithiocarbamate anti-wear additive, and 2 to 30 wt% of other lubricating oil additives, and wherein the Group III base stock is a GTL base stock, wherein the cobase stock is selected from the group consisting of a Group I, a Group IV, a Group V and combinations thereof, wherein the Group I cobase stock is bright stock; the Group IV cobase stock is a Friedel-Crafts catalyzed PAO base stock or a metallocene catalyzed PAO base stock; and/or the Group V cobase stock is selected from the group consisting of polyisobutylene, polymethacrylate and combinations thereof, wherein KV100 is as measured by ASTM D445.
Device for generating a pulsating hydraulic fluid pressure in a working chamber filled with hydraulic fluid with a drivable working piston movably guided in a hollow working cylinder, wherein a working chamber that is in fluid communication with the working piston is provided such that, by means of a movement of the working piston within the hollow working cylinder, a pulsating hydraulic fluid pressure can be generated in the working chamber, characterized in that an auxiliary piston is movably guided in a hollow auxiliary cylinder and is in fluid communication with an additional chamber, wherein a closeable auxiliary channel is provided, which connects the additional chamber and the working chamber, wherein the auxiliary piston and hollow auxiliary cylinder are formed and arranged in such a way that, by moving the auxiliary piston within the hollow auxiliary cylinder, a hydraulic fluid arranged in the additional chamber can at least partly be forced out of the additional chamber into the auxiliary channel and from the auxiliary channel into the working chamber, wherein the auxiliary piston divides the additional chamber into a front and a rear additional chamber section (21, 18), wherein the auxiliary piston can be moved in such a way that hydraulic fluid can be forced from the front additional chamber section into the auxiliary channel and from the auxiliary channel into the working chamber, and the auxiliary piston and the hollow auxiliary cylinder are formed in such a way that, during the movement, the auxiliary piston passes through a first and a second stroke section, wherein hydraulic fluid can only be transferred from the additional chamber into the auxiliary channel and from the auxiliary channel into the working chamber in the first stroke section, with the result that additional hydraulic fluid is brought from the additional chamber into the working chamber at the start of a pressure stroke.
An airbrush comprising: an air-supply module comprising a battery, an air-supply unit for discharging a compressed air when electric power is supplied, and a switch for supplying or blocking the electric power of the battery to the air-supply unit; and a spray head having a spray hole at one side of the spray head and detachably coupled to the air-supply module, wherein the spray head comprises: a storage tank for storing a spray liquid; a needle valve for discharging or blocking the spray liquid stored in the storage tank to a discharging hole formed at the spray hole; a valve frame for supporting the needle valve, wherein the valve frame comprises: an air-supplying passage where the compressed air flows; and an orifice member adjacent to the discharging hole and for spraying or spurting the compressed air that flows through the air-supplying passage to the spray hole; and a trigger for operating the needle valve and the switch at the same time. an air-supply module comprising a battery, an air-supply unit for discharging a compressed air when electric power is supplied, and a switch for supplying or blocking the electric power of the battery to the air-supply unit; and a spray head having a spray hole at one side of the spray head and detachably coupled to the air-supply module, wherein the spray head comprises: a storage tank for storing a spray liquid; a needle valve for discharging or blocking the spray liquid stored in the storage tank to a discharging hole formed at the spray hole; a valve frame for supporting the needle valve, wherein the valve frame comprises: an air-supplying passage where the compressed air flows; and an orifice member adjacent to the discharging hole and for spraying or spurting the compressed air that flows through the air-supplying passage to the spray hole; and a trigger for operating the needle valve and the switch at the same time. a storage tank for storing a spray liquid; a needle valve for discharging or blocking the spray liquid stored in the storage tank to a discharging hole formed at the spray hole; a valve frame for supporting the needle valve, wherein the valve frame comprises: an air-supplying passage where the compressed air flows; and an orifice member adjacent to the discharging hole and for spraying or spurting the compressed air that flows through the air-supplying passage to the spray hole; and a trigger for operating the needle valve and the switch at the same time.
An apparatus for making a three-dimensional object from a photohardenable resin, comprising: a source of the photohardenable resin; an ultraviolet laser diode moveable in a first direction, wherein the ultraviolet laser diode is configured to selectively project solidification energy in a second direction as it moves in the first direction; a rotating polygonal mirror having one or more facets (94a - 94f) defined around its perimeter, said rotating polygonal mirror being moveable in the first direction and rotatable in a rotation plane that is substantially perpendicular to the first direction, wherein the rotating polygonal mirror is in optical communication with the ultraviolet laser diode, and when the ultraviolet laser diode projects solidification energy in the second direction, the rotating polygonal mirror is configured to deflect the solidification energy toward the photohardenable resin, and the deflected solidification energy solidifies the photohardenable resin. a source of the photohardenable resin; an ultraviolet laser diode moveable in a first direction, wherein the ultraviolet laser diode is configured to selectively project solidification energy in a second direction as it moves in the first direction; a rotating polygonal mirror having one or more facets (94a - 94f) defined around its perimeter, said rotating polygonal mirror being moveable in the first direction and rotatable in a rotation plane that is substantially perpendicular to the first direction, wherein the rotating polygonal mirror is in optical communication with the ultraviolet laser diode, and when the ultraviolet laser diode projects solidification energy in the second direction, the rotating polygonal mirror is configured to deflect the solidification energy toward the photohardenable resin, and the deflected solidification energy solidifies the photohardenable resin.
A composition for use in the treatment of biofilm-based infections in direct application to a site of infectious biofilm of humans, the composition comprising trehalase.