A hand-held dermaplaning device comprising; a main housing (304, 306) including first and second rails extending in a longitudinal direction; a subsonic vibration generator carried by the main housing for generating vibrations in the main housing; a power supply carried by the main housing (304, 306) for powering d e vibration generator; a switch (406, 407) carried by the main housing (304, 306) for selectively connecting the power supply to the vibration generator; and a blade assembly including an elongated blade holder configured to be slidably attached to the main housing (304, 306) in the longitudinal direction, an elongated blade supported by the blade holder having a cutting edge extending in the longitudinal direction and a safety cage juxtaposed over the blade, preferably disposed over the cutting edge and/or including teeth, and configured to limit the depth that the blade can penetrate the skin, the blade holder including first and second slots, preferably parallel aligned slots, extending in the longitudinal direction along first and second sides of the blade holder and configured to slidably receive the first and second rails of the main housing (304, 306) to detachably couple the blade assembly to the main housing (304, 306), the blade holder including one or more first notches (333, 335) located on the first side of the blade holder and one or more second notches (333, 335) located on the second side of the blade holder, the first and second notches (333, 335) located between the first and second slots and the cutting edge, each of the first and second notches (333, 335) configured to cooperate with a blade retainer to hold the blade holder in position on the blade retainer for slidably attaching the blade assembly to the main housing (304, 306) when the blade assembly is held by the blade retainer.. a main housing (304, 306) including first and second rails extending in a longitudinal direction; a subsonic vibration generator carried by the main housing for generating vibrations in the main housing; a power supply carried by the main housing (304, 306) for powering d e vibration generator; a switch (406, 407) carried by the main housing (304, 306) for selectively connecting the power supply to the vibration generator; and a blade assembly including an elongated blade holder configured to be slidably attached to the main housing (304, 306) in the longitudinal direction, an elongated blade supported by the blade holder having a cutting edge extending in the longitudinal direction and a safety cage juxtaposed over the blade, preferably disposed over the cutting edge and/or including teeth, and configured to limit the depth that the blade can penetrate the skin, the blade holder including first and second slots, preferably parallel aligned slots, extending in the longitudinal direction along first and second sides of the blade holder and configured to slidably receive the first and second rails of the main housing (304, 306) to detachably couple the blade assembly to the main housing (304, 306), the blade holder including one or more first notches (333, 335) located on the first side of the blade holder and one or more second notches (333, 335) located on the second side of the blade holder, the first and second notches (333, 335) located between the first and second slots and the cutting edge, each of the first and second notches (333, 335) configured to cooperate with a blade retainer to hold the blade holder in position on the blade retainer for slidably attaching the blade assembly to the main housing (304, 306) when the blade assembly is held by the blade retainer..