A computer-implemented method for determining one or more candidate transducer array layout maps, comprising: determining a region-of-interest within a three-dimensional model of a portion of a subject's body generated from imaging data captured from the subject; determining, based on a center of the region-of-interest, a plane that transverses the portion of the subject's body, wherein the plane comprises a plurality of pairs of simulated positions along a boundary of the plane at which transducer arrays (120A, B) may be affixed to the subject, wherein each of the pairs of simulated positions are located at opposing positions with respect to the region of interest along a centerline connecting the opposing positions and intersecting with the region of interest; adjusting, based on an anatomical restriction defining one or more areas of the subject to be avoided for placement of the transducer arrays (120A, B), one or more positions of the plurality of pairs of simulated positions to generate only anatomically-valid positions for the pairs of transducer arrays (120A, B); determining, for each pair of transducer arrays (120A, B) at each of the plurality of pairs of simulated positions as adjusted based on the anatomical restriction, based on dielectric properties for relative conductivity and permittivity assigned to different tissue types of the three-dimensional model, a simulated electric field distribution; determining, based on the simulated electric field distributions, a metric of electric field intensity in the region-of-interest for each of the plurality of pairs of simulated positions; determining one or more sets of pairs of positions of the plurality of pairs of simulated positions that satisfy an angular restriction between the pairs of transducer arrays (120A, B), with the angular restriction being assessed based on the centerlines of the respective pairs of simulated positions; and determining, based on the metric of simulated electric field intensity for the one or more sets of pairs of positions of the plurality of pairs of simulated positions that satisfy the angular restriction, one or more candidate transducer array layout maps. determining a region-of-interest within a three-dimensional model of a portion of a subject's body generated from imaging data captured from the subject; determining, based on a center of the region-of-interest, a plane that transverses the portion of the subject's body, wherein the plane comprises a plurality of pairs of simulated positions along a boundary of the plane at which transducer arrays (120A, B) may be affixed to the subject, wherein each of the pairs of simulated positions are located at opposing positions with respect to the region of interest along a centerline connecting the opposing positions and intersecting with the region of interest; adjusting, based on an anatomical restriction defining one or more areas of the subject to be avoided for placement of the transducer arrays (120A, B), one or more positions of the plurality of pairs of simulated positions to generate only anatomically-valid positions for the pairs of transducer arrays (120A, B); determining, for each pair of transducer arrays (120A, B) at each of the plurality of pairs of simulated positions as adjusted based on the anatomical restriction, based on dielectric properties for relative conductivity and permittivity assigned to different tissue types of the three-dimensional model, a simulated electric field distribution; determining, based on the simulated electric field distributions, a metric of electric field intensity in the region-of-interest for each of the plurality of pairs of simulated positions; determining one or more sets of pairs of positions of the plurality of pairs of simulated positions that satisfy an angular restriction between the pairs of transducer arrays (120A, B), with the angular restriction being assessed based on the centerlines of the respective pairs of simulated positions; and determining, based on the metric of simulated electric field intensity for the one or more sets of pairs of positions of the plurality of pairs of simulated positions that satisfy the angular restriction, one or more candidate transducer array layout maps.