mhurhangee/ep-ind-claims huggingface dataset:
A compound, or pharmaceutically acceptable salt, hydrate or solvate thereof, wherein the compound has the structural formula Id shown below: wherein: R 1 is selected from alkyl, cycloalkyl and heterocyclyl; wherein each of said substituents is optionally substituted by one or more substituent groups independently selected from alkyl, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, cyano, carboxy, carbamoyl, sulphamoyl, mercapto, ureido, NR c R d, C R c, C OR c, OC R c, N(R d)C R c, S y R c where y is 0, 1 or 2, SO 2 N(R d)R c, N(R d)SO 2 R c, Si(R d)(R c)R e and (CH 2) z NR d R c where z is 1, 2 or 3; wherein R c, R d and R e are each independently selected from alkyl and cycloalkyl; R 2 is hydrogen; X 4 is CR n, and wherein R n is selected from hydrogen, halo, alkyl and amino; Q 3 is hydrogen, alkyl, alkoxy, aryl, aryl alkyl, cycloalkyl, heteroaryl or heterocyclyl; wherein Q 3 is optionally substituted by one or more substituent groups independently selected from alkyl, halo, amino, cyano, hydroxy, NR t R u, and OR t, wherein R t and R u are each independently selected from hydrogen and alkyl; or Q 3 is optionally substituted by a group of the formula: -L 4 -L Q4 -Z 4 wherein: L 4 is absent or is alkylene; L Q4 is absent or is O; and Z 4 is hydrogen, alkyl, or cycloalkyl; wherein Z 4 is optionally substituted by one or more substituents selected from alkyl, alkoxy, amino, hydroxy, cycloalkyl, NR x R y, and OR x; wherein R x and R y are each independently selected from hydrogen and alkyl. R 1 is selected from alkyl, cycloalkyl and heterocyclyl; wherein each of said substituents is optionally substituted by one or more substituent groups independently selected from alkyl, halo, haloalkyl, haloalkoxy, amino, aminoalkyl, cyano, carboxy, carbamoyl, sulphamoyl, mercapto, ureido, NR c R d, C R c, C OR c, OC R c, N(R d)C R c, S y R c where y is 0, 1 or 2, SO 2 N(R d)R c, N(R d)SO 2 R c, Si(R d)(R c)R e and (CH 2) z NR d R c where z is 1, 2 or 3; wherein R c, R d and R e are each independently selected from alkyl and cycloalkyl; R 2 is hydrogen; X 4 is CR n, and wherein R n is selected from hydrogen, halo, alkyl and amino; Q 3 is hydrogen, alkyl, alkoxy, aryl, aryl alkyl, cycloalkyl, heteroaryl or heterocyclyl; wherein Q 3 is optionally substituted by one or more substituent groups independently selected from alkyl, halo, amino, cyano, hydroxy, NR t R u, and OR t, wherein R t and R u are each independently selected from hydrogen and alkyl; or Q 3 is optionally substituted by a group of the formula: -L 4 -L Q4 -Z 4 wherein: L 4 is absent or is alkylene; L Q4 is absent or is O; and Z 4 is hydrogen, alkyl, or cycloalkyl; wherein Z 4 is optionally substituted by one or more substituents selected from alkyl, alkoxy, amino, hydroxy, cycloalkyl, NR x R y, and OR x; wherein R x and R y are each independently selected from hydrogen and alkyl. L 4 is absent or is alkylene; L Q4 is absent or is O; and Z 4 is hydrogen, alkyl, or cycloalkyl; wherein Z 4 is optionally substituted by one or more substituents selected from alkyl, alkoxy, amino, hydroxy, cycloalkyl, NR x R y, and OR x; wherein R x and R y are each independently selected from hydrogen and alkyl.
A method for manufacturing a packaging, in particular a heat-sealed plastic packaging, which comprises at least one product cavity of a formed part closed by means of a covering film, wherein the method comprises the following steps: a) defining a seam to be produced, along which the covering film is to be sealed to the formed part around the product cavity; b) dividing the seam to be produced into a plurality of sections (A1, A2, A3), which comprise at least a first section and a second section; c) determining a pulling-off force for pulling the covering film from the formed part, at least for the first section of the plurality of sections (A1, A2, A3) and preferably a pulling-off force respectively for each section of the plurality of sections (A1, A2, A3); d) sealing the covering film to the formed part along the seam by means of a sealing device with a first sealing temperature in the first section and a second sealing temperature in the second section, wherein the first and the second sealing temperatures are different, and wherein at least the first sealing temperature for the first section is chosen on the basis of the pulling-off force determined according to step c); characterized in that the sealing device has a sealing contour, which is divided into a plurality of segments, wherein at least a first segment of the plurality of segments is assigned to the first section of the seam and at least a second segment of the plurality of segments is assigned to the second section of the seam, and step d) comprises heating the plurality of segments in accordance with the sealing temperatures. a) defining a seam to be produced, along which the covering film is to be sealed to the formed part around the product cavity; b) dividing the seam to be produced into a plurality of sections (A1, A2, A3), which comprise at least a first section and a second section; c) determining a pulling-off force for pulling the covering film from the formed part, at least for the first section of the plurality of sections (A1, A2, A3) and preferably a pulling-off force respectively for each section of the plurality of sections (A1, A2, A3); d) sealing the covering film to the formed part along the seam by means of a sealing device with a first sealing temperature in the first section and a second sealing temperature in the second section, wherein the first and the second sealing temperatures are different, and wherein at least the first sealing temperature for the first section is chosen on the basis of the pulling-off force determined according to step c);
A method of reprofiling a wheel set of a railway vehicle on a station comprising: disposing the wheel set on rollers; determining a center of rotation of a wheel on the wheel set; determining a desired constant distance between a cutting tool and the center of rotation of the wheel; and rotating the wheel; the method characterized in that when the cutting tool is used to mill a profile on the wheel, (i) the center of rotation of the wheel is allowed to move relative to the rollers while the rollers are maintained in a fixed location on the station, (ii) radial horizontal and vertical changes in position of the center of rotation of the wheel are tracked while the wheel is being rotated and after the cutting tool has been activated, and (iii) the cutting tool is moved to facilitate its location at the desired constant distance between the cutting tool and the center of rotation of the wheel. disposing the wheel set on rollers; determining a center of rotation of a wheel on the wheel set; determining a desired constant distance between a cutting tool and the center of rotation of the wheel; and rotating the wheel; the method characterized in that when the cutting tool is used to mill a profile on the wheel, (i) the center of rotation of the wheel is allowed to move relative to the rollers while the rollers are maintained in a fixed location on the station, (ii) radial horizontal and vertical changes in position of the center of rotation of the wheel are tracked while the wheel is being rotated and after the cutting tool has been activated, and (iii) the cutting tool is moved to facilitate its location at the desired constant distance between the cutting tool and the center of rotation of the wheel.
Multi-layered component comprising an inert ceramic substrate, which comprises an LTCC ceramic, at least one functional ceramic, which is completely enclosed by the ceramic substrate and comprises an HTCC ceramic, and internal electrodes in the ceramic substrate for electrically contacting the functional ceramic.
A vehicle seat device comprising: a seat body including a seat cushion and a seatback; at least a pair of airbag modules provided as a left-right pair at left and right side portions of the seat body; and at least two moveable sections each supporting one of the airbag modules and wherein each movable section is movable with respect to the seat body, characterized in that the airbag modules are moved, by movement of the moveable sections, between first positions along side portions of the seat body, and second positions in front of a front face of the seatback, and airbags deployed from the airbag modules in the second positions sandwich an occupant seated in the seat body between the airbags and the seatback. a seat body including a seat cushion and a seatback; at least a pair of airbag modules provided as a left-right pair at left and right side portions of the seat body; and at least two moveable sections each supporting one of the airbag modules and wherein each movable section is movable with respect to the seat body, characterized in that the airbag modules are moved, by movement of the moveable sections, between first positions along side portions of the seat body, and second positions in front of a front face of the seatback, and airbags deployed from the airbag modules in the second positions sandwich an occupant seated in the seat body between the airbags and the seatback.
Pneumatic vehicle tyre having a tread with a directional tread profile and having at least one profile band which is delimited by two circumferential channels (1, 1') and in which a multiplicity of oblique channels extend, wherein each oblique channel is delimited by two mutually opposite channel flanks (8, 8') and by a channel base which connects the channel flanks (8, 8'), wherein the oblique channel has a first channel portion, a central channel portion and a channel end portion, wherein at least two of these portions (4, 5) have mutually different cross-sectional areas, wherein the first channel portion tapers off within the profile band, and at least the first and the central channel portion (4, 5) run at an at least substantially equal angle (α) of 10° to 20° with respect to the circumferential direction, wherein, as the tyre rolls, the oblique channel enters the ground contact patch with the first channel portion first, characterized in that the depth of the oblique channel, at least in the first channel portion, and proceeding from the channel end which tapers off within the profile band, increases in particular continuously to a first depth (T 2), wherein, in the central channel portion, proceeding from the first depth (T 2), there is formed a channel base sipe which runs at least over the major part of the extent of the central channel portion and which extends into a second depth (T 1), and wherein, at least in the central channel portion, the channel flanks (8, 8') are adjoined by oblique flanks (7c, 7'c) belonging to the channel base, which oblique flanks run at an angle (ε) of 40° to 50° with respect to the radial direction.
A negative modulator of a GABA A receptor, for use in a method of treating or preventing or ameliorating at least one symptom of a medical condition in an individual, the method comprising the step of providing to the individual a therapeutically effective amount of the negative modulator of a GABA A receptor, wherein the medical condition is selected from the group consisting of a depression-related disorder; suicidality; and a combination thereof, wherein the negative modulator of GABA A receptor is a partial inverse agonist of a GABA A receptor comprising an α5 subunit.
A method for combining a first reconstructed tomographic volume data set with a second reconstructed tomographic volume data set, which were taken under different conditions with an x-ray imaging microscopy system, comprising Displaying slices of first tomographic volume data set and of a second tomographic volume data set; Selecting a common slice among slices of the reconstructed tomographic volume data sets; Creating a two-dimensional histogram of pixel intensity values for the selected slice in both tomographic volume data sets; Selecting one or more regions of interest within the two-dimensional histogram; Creating a synthetic slice by combining of both corresponding slices of the first and second tomographic volume data sets taking into account the selected regions of interest; Creating a combined reconstructed volume data set from the synthetic slices; characterized in that the Creating of the two-dimensional histogram further comprises: Creating a sum histogram, where values of the points are the resulting sum of the corresponding pixels across the selected slices and/or Creating an average histogram, where values of the points are the resulting sum divided by the number of slices selected of the corresponding pixels across the selected slices. Displaying slices of first tomographic volume data set and of a second tomographic volume data set; Selecting a common slice among slices of the reconstructed tomographic volume data sets; Creating a two-dimensional histogram of pixel intensity values for the selected slice in both tomographic volume data sets; Selecting one or more regions of interest within the two-dimensional histogram; Creating a synthetic slice by combining of both corresponding slices of the first and second tomographic volume data sets taking into account the selected regions of interest; Creating a combined reconstructed volume data set from the synthetic slices; characterized in that the Creating of the two-dimensional histogram further comprises: Creating a sum histogram, where values of the points are the resulting sum of the corresponding pixels across the selected slices and/or Creating an average histogram, where values of the points are the resulting sum divided by the number of slices selected of the corresponding pixels across the selected slices.
Device for connection to a circuit for supplying heat-conveying fluid for an air-conditioning circuit of a motor vehicle, the device comprising an inlet pipe and an outlet pipe for the fluid, and at least one clamp for connection to at least one of said pipes, said clamp being brazed on one side and crimped on the other, characterised in that the device also comprises an air-conditioning circuit tube and a double-skinned sleeve for exchanging heat with the tube, defining an annular passage between the tube and the sleeve, in that the clamp is fixed on the tube by brazing and comprises a lateral bore for passage of the fluid to the annular space, in that said bore is connected to the inlet and/or outlet pipe (4, 5) of the supply circuit by a connecting union formed by a male end piece of said pipe having a protruding lip defining one end of the end piece comprising at least one groove provided with an O-ring seal, and on the clamp side by a tapping integral with the clamp comprising a first proximal portion defining the lateral bore, cooperating by mild friction with the end of the end piece, and a second distal portion which is deformable and defines a cavity cooperating by friction with the lip over which it is crimped.
Method for forming a chemical guiding structure (200, 200') intended for self-assembly of a block copolymer by chemoepitaxy, the method comprising the following steps: - forming on a substrate a functionalisation layer made of a first polymer material having a first chemical affinity with respect to the block copolymer; - forming on the substrate guiding patterns made of a second polymer material having a second chemical affinity with respect to the block copolymer, different from the first chemical affinity; characterised in that the guiding patterns have a critical dimension of less than 12.5 nm and are formed by means of a mask comprising spacers (130, 311). - forming on a substrate a functionalisation layer made of a first polymer material having a first chemical affinity with respect to the block copolymer; - forming on the substrate guiding patterns made of a second polymer material having a second chemical affinity with respect to the block copolymer, different from the first chemical affinity;
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is CD 3; and R 2 is CH 3; for use in a method of treatment or diagnosis of the human or animal body. R 1 is CD 3; and R 2 is CH 3;
A recombinant Listeria monocytogenes strain expressing a recombinant polypeptide, said recombinant polypeptide comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA) protein encoded by a nucleotide sequence selected from SEQ ID NOs: 21-23, wherein said recombinant polypeptide comprises a PEST sequence from Listeria.
A method for recording multiple instances of content, comprising: receiving, at a content receiver, an instruction to initiate recording; in response to the instruction, setting at the content receiver a first tuner (107/220) to a first carrier frequency; further in response to the instruction, setting at the content receiver a second tuner (107/220) to a second carrier frequency; receiving a first set of content at the first tuner, the first set of content scrambled with a control word, wherein the first set of content comprises a first television program; receiving a second set of content at the second tuner, the second set of content scrambled with the control word, wherein the second set of content comprises a different, second television program; decrypting, by the content receiver, an entitlement control message to obtain the control word; descrambling, using a single descrambler (110/220) of the content receiver and using the decrypted control word, the first and second sets of content received at the first and second tuner; recording the descrambled first and second sets of content on a storage medium. receiving, at a content receiver, an instruction to initiate recording; in response to the instruction, setting at the content receiver a first tuner (107/220) to a first carrier frequency; further in response to the instruction, setting at the content receiver a second tuner (107/220) to a second carrier frequency; receiving a first set of content at the first tuner, the first set of content scrambled with a control word, wherein the first set of content comprises a first television program; receiving a second set of content at the second tuner, the second set of content scrambled with the control word, wherein the second set of content comprises a different, second television program; decrypting, by the content receiver, an entitlement control message to obtain the control word; descrambling, using a single descrambler (110/220) of the content receiver and using the decrypted control word, the first and second sets of content received at the first and second tuner; recording the descrambled first and second sets of content on a storage medium.
A fluidized bed combustion system comprising a furnace, a solids separator in fluid communication with the furnace; the separator comprising a vortex finder; and an outlet duct in fluid communication with the vortex finder; the outlet duct having a NOx reducing system located downstream of the vortex finder, the NOx reducing system comprising: a first inner conduit in fluid communication with a reactant source; and a first outer conduit comprising an open end for receiving the first inner conduit and a closed end; the first outer conduit comprising a plurality of ports (44, 46, 48, 50) for discharging reactant from the reactant source into an exhaust gas stream, wherein the ports are located on a downstream side of the first outer conduit; the downstream side being defined by a flow direction of the exhaust gas stream in the duct. a first inner conduit in fluid communication with a reactant source; and a first outer conduit comprising an open end for receiving the first inner conduit and a closed end; the first outer conduit comprising a plurality of ports (44, 46, 48, 50) for discharging reactant from the reactant source into an exhaust gas stream, wherein the ports are located on a downstream side of the first outer conduit; the downstream side being defined by a flow direction of the exhaust gas stream in the duct.
Dispenser machine for paste-like food products comprising a framework, and a group for dispensing said substances associated to said framework, said dispenser group comprising a removable hollow cylindrical element for containing said substances, closed at a first end by a closure bottom, a piston element accommodated inside said container element moveable from said first end up to an opposite end of said container element for filling said substances, provided for being a compressor accommodated inside said framework and connected to said first end of said container element for moving said piston element through compressed air, said machine further comprising an outlet group for said substances coupled to said opposite end of said container element, provided for being means for controlling the internal pressure of said container element as well as automatic means for reducing the internal pressure of said container element, characterised in that it comprises a seat for accommodating said container element and means for blocking said container element into said accommodation seat, said means for blocking said container element into said accommodation seat comprising a closure door integral with said bottom, said closure door being moveable in rotation around a pin and being provided with a threaded rotating knob constrained at an end against said closure door and associable in a threaded manner at the other end with a support integral with said framework, said automatic means for releasing the internal pressure of said container element comprising an electromechanical sensor with a sensing device arranged at a position at the threaded end of said knob and connected to a vent valve.
A damping device for dampening a movement of a movably-mounted furniture part or a movably-mounted furniture fitting component of a furniture fitting, comprising: - a housing, - a slider configured to be moved, in particular displaced, relative to the housing, - a fluid chamber either arranged in the housing or in the slider, - a piston arranged in the fluid chamber, wherein a damping action is produced by a relative movement between the fluid chamber and the piston, and wherein the piston adopts a pressed-in end position relative to the fluid chamber at an end of a damping stroke, - a locking device having an arresting element configured to be actuated manually or with the aid of a tool for deactivating the damping action, wherein the relative position between the fluid chamber and the piston can be releasably locked by the arresting element in the pressed-in end position, - wherein the housing is provided with a recess in which the arresting element is movably supported, characterized in that the arresting element is passed through the recess, wherein the arresting element is configured as a linearly displaceable switch having at least two switching positions, wherein in a first switching position, the damping action of the damping device is activated, and, in a second switching position, the damping action of the damping device is deactivated. - a housing, - a slider configured to be moved, in particular displaced, relative to the housing, - a fluid chamber either arranged in the housing or in the slider, - a piston arranged in the fluid chamber, wherein a damping action is produced by a relative movement between the fluid chamber and the piston, and wherein the piston adopts a pressed-in end position relative to the fluid chamber at an end of a damping stroke, - a locking device having an arresting element configured to be actuated manually or with the aid of a tool for deactivating the damping action, wherein the relative position between the fluid chamber and the piston can be releasably locked by the arresting element in the pressed-in end position, - wherein the housing is provided with a recess in which the arresting element is movably supported,