A gusseted stand-up flexible pouch (210; 510) comprising: a pouch-forming structure including first and second opposing body panels (212, 214; 512, 514), first and second opposing side gussets (216, 218; 516, 518), a bottom gusset (220; 520) and a plurality of interior gussets (222, 224; 522, 524, 532, 534), the bottom gusset extending between the first body panel (212; 512) and the second body panel (214; 514), the bottom gusset extending between the first and second side gussets (216, 218; 516, 518), each of the first and second side gussets (216, 218; 516, 518) being joined to the first body panel (212; 512) and the second body panel (214; 514), the plurality of interior gussets (222, 224; 522, 524, 532, 534) being joined to the first body panel (212; 512) and the second body panel (214; 514), the plurality of interior gussets (222, 224; 522, 524, 532, 534) being located between the first (216; 516) and the second side gusset (216; 516), wherein the plurality of interior gussets (222, 224; 522, 524, 532, 534) divide an interior of the stand-up flexible pouch (210; 510) into a plurality of compartments (226a, 226b; 526a, 526b, 526c), wherein the stand-up flexible pouch (210; 510) is configured to have the bottom gusset form a flat bottom in an upright configuration, the flat bottom extending between the first and second body panels (212, 214; 512, 514), the flat bottom further extending between the first and second side gussets (216, 218; 516, 518), the flat bottom having an interior surface and an exterior surface, the entire exterior surface of the flat bottom is configured to contact a flat surface when in an upright configuration, the stand-up flexible pouch (210; 510) further includes a top portion (240; 540) opposite of the bottom gusset, the top portion (240; 540) including a resealable fastener (246a, 246b; 546a, 546b, 546c), characterized in that the pouch-forming structure includes at least one pouch-forming structure separating line of weakness (260; 560a, 560b), the at least one pouch-forming structure line of weakness extending (260; 560a, 560b) from the first body panel (212; 512) around the bottom gusset and to the second body panel (214; 514), the at least one pouch-forming structure line of weakness (260; 560a, 560b) assisting in separating the pouch-forming structure into at least two separated pouches. a pouch-forming structure including first and second opposing body panels (212, 214; 512, 514), first and second opposing side gussets (216, 218; 516, 518), a bottom gusset (220; 520) and a plurality of interior gussets (222, 224; 522, 524, 532, 534), the bottom gusset extending between the first body panel (212; 512) and the second body panel (214; 514), the bottom gusset extending between the first and second side gussets (216, 218; 516, 518), each of the first and second side gussets (216, 218; 516, 518) being joined to the first body panel (212; 512) and the second body panel (214; 514), the plurality of interior gussets (222, 224; 522, 524, 532, 534) being joined to the first body panel (212; 512) and the second body panel (214; 514), the plurality of interior gussets (222, 224; 522, 524, 532, 534) being located between the first (216; 516) and the second side gusset (216; 516), wherein the plurality of interior gussets (222, 224; 522, 524, 532, 534) divide an interior of the stand-up flexible pouch (210; 510) into a plurality of compartments (226a, 226b; 526a, 526b, 526c), wherein the stand-up flexible pouch (210; 510) is configured to have the bottom gusset form a flat bottom in an upright configuration, the flat bottom extending between the first and second body panels (212, 214; 512, 514), the flat bottom further extending between the first and second side gussets (216, 218; 516, 518), the flat bottom having an interior surface and an exterior surface, the entire exterior surface of the flat bottom is configured to contact a flat surface when in an upright configuration, the stand-up flexible pouch (210; 510) further includes a top portion (240; 540) opposite of the bottom gusset, the top portion (240; 540) including a resealable fastener (246a, 246b; 546a, 546b, 546c), characterized in that the pouch-forming structure includes at least one pouch-forming structure separating line of weakness (260; 560a, 560b), the at least one pouch-forming structure line of weakness extending (260; 560a, 560b) from the first body panel (212; 512) around the bottom gusset and to the second body panel (214; 514), the at least one pouch-forming structure line of weakness (260; 560a, 560b) assisting in separating the pouch-forming structure into at least two separated pouches.