A tissue-removing catheter comprising: an elongate catheter body configured for insertion into a body lumen of a subject, the catheter body having a proximal end portion, an opposite distal end portion, and a longitudinal axis extending between the distal and proximal end portions; a tissue-removing element located adjacent the distal end portion of the catheter body configured to remove tissue from the body lumen; first and second adjustment lines (82, 84) extending along the catheter body at circumferentially spaced apart locations about the longitudinal axis, the first and second adjustment lines (82, 84) having distal end portions attached to the catheter body at respective first and second connection points adjacent the distal end portion of the catheter body, and an opposite proximal end portion; and an adjustment mechanism operatively connected to the proximal end portions of the first and second adjustment lines (82, 84), wherein the adjustment mechanism is selectively operable to decrease an effective length of the first adjustment line extending between the first connection point and the adjustment mechanism to bend the distal end portion of the catheter body in a first direction and urge the tissue-removing element in the first direction, wherein the adjustment mechanism is selectively operable to decrease an effective length of the second adjustment line extending between the second connection point and the adjustment mechanism to bend the distal end portion of the catheter body in a second direction different than the first direction and urge the tissue-removing element in the second direction, wherein the distal end portion includes a bending longitudinal portion, wherein the bending longitudinal portion has a bending stiffness that is less than a bending stiffness of a longitudinal portion of the catheter body that is immediately proximal the bending longitudinal portion, wherein the catheter body includes a drive shaft extending along the longitudinal axis and a jacket extending circumferentially around the drive shaft, and wherein the catheter body further includes a support coil received in the jacket and extending circumferentially around the drive shaft. an elongate catheter body configured for insertion into a body lumen of a subject, the catheter body having a proximal end portion, an opposite distal end portion, and a longitudinal axis extending between the distal and proximal end portions; a tissue-removing element located adjacent the distal end portion of the catheter body configured to remove tissue from the body lumen; first and second adjustment lines (82, 84) extending along the catheter body at circumferentially spaced apart locations about the longitudinal axis, the first and second adjustment lines (82, 84) having distal end portions attached to the catheter body at respective first and second connection points adjacent the distal end portion of the catheter body, and an opposite proximal end portion; and an adjustment mechanism operatively connected to the proximal end portions of the first and second adjustment lines (82, 84), wherein the adjustment mechanism is selectively operable to decrease an effective length of the first adjustment line extending between the first connection point and the adjustment mechanism to bend the distal end portion of the catheter body in a first direction and urge the tissue-removing element in the first direction, wherein the adjustment mechanism is selectively operable to decrease an effective length of the second adjustment line extending between the second connection point and the adjustment mechanism to bend the distal end portion of the catheter body in a second direction different than the first direction and urge the tissue-removing element in the second direction, wherein the distal end portion includes a bending longitudinal portion, wherein the bending longitudinal portion has a bending stiffness that is less than a bending stiffness of a longitudinal portion of the catheter body that is immediately proximal the bending longitudinal portion, wherein the catheter body includes a drive shaft extending along the longitudinal axis and a jacket extending circumferentially around the drive shaft, and wherein the catheter body further includes a support coil received in the jacket and extending circumferentially around the drive shaft.