An engine system comprising: a cylinder block defining at least two cylinders (51, 52, 53, 54, 55, 56) including a first cylinder and a second cylinder arranged in a row with an end; a fuel system configured to intermittently supply a first fuel stream to the first cylinder and to intermittently supply a second fuel stream to the second cylinder; an intake system supplying combustion air to the cylinders; an exhaust manifold connected to the cylinder block to receive, via respective inlets (61, 62, 63, 64, 65, 66), the exhaust gas from the cylinders, the exhaust manifold having one interior chamber through which the exhaust gas from the cylinders passes; an exhaust system configured to receive exhaust gas from the exhaust manifold; and an exhaust gas recirculation circuit connected between the exhaust manifold and the intake system; wherein, the interior chamber is configured to: intermittently open to the cylinders; continuously open to the exhaust system; and continuously open to the EGR circuit, and wherein, the exhaust manifold includes an EGR takeoff, connected to the EGR circuit, and disposed at the end such that all of the inlets to the interior chamber from the at least two cylinders are on one side of the EGR takeoff in a longitudinal direction of the exhaust manifold, the EGR takeoff located at the end adjacent the second cylinder; the engine system further comprising, an EGR valve disposed in the EGR circuit; and a controller configured to: operate the fuel system to supply the first fuel stream to deliver fuel to the exhaust system while operating the fuel system to stop the second fuel stream from delivering fuel to the exhaust system; and open, concurrently with operating the fuel system to supply the first fuel stream, the EGR valve to supply a portion of the exhaust gas from the second cylinder to the intake system. a cylinder block defining at least two cylinders (51, 52, 53, 54, 55, 56) including a first cylinder and a second cylinder arranged in a row with an end; a fuel system configured to intermittently supply a first fuel stream to the first cylinder and to intermittently supply a second fuel stream to the second cylinder; an intake system supplying combustion air to the cylinders; an exhaust manifold connected to the cylinder block to receive, via respective inlets (61, 62, 63, 64, 65, 66), the exhaust gas from the cylinders, the exhaust manifold having one interior chamber through which the exhaust gas from the cylinders passes; an exhaust system configured to receive exhaust gas from the exhaust manifold; and an exhaust gas recirculation circuit connected between the exhaust manifold and the intake system; wherein, the interior chamber is configured to: intermittently open to the cylinders; continuously open to the exhaust system; and continuously open to the EGR circuit, and wherein, the exhaust manifold includes an EGR takeoff, connected to the EGR circuit, and disposed at the end such that all of the inlets to the interior chamber from the at least two cylinders are on one side of the EGR takeoff in a longitudinal direction of the exhaust manifold, the EGR takeoff located at the end adjacent the second cylinder; the engine system further comprising, an EGR valve disposed in the EGR circuit; and a controller configured to: operate the fuel system to supply the first fuel stream to deliver fuel to the exhaust system while operating the fuel system to stop the second fuel stream from delivering fuel to the exhaust system; and open, concurrently with operating the fuel system to supply the first fuel stream, the EGR valve to supply a portion of the exhaust gas from the second cylinder to the intake system. operate the fuel system to supply the first fuel stream to deliver fuel to the exhaust system while operating the fuel system to stop the second fuel stream from delivering fuel to the exhaust system; and open, concurrently with operating the fuel system to supply the first fuel stream, the EGR valve to supply a portion of the exhaust gas from the second cylinder to the intake system.