A compound of Formula or its stereoisomers or tautomers, or pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, wherein R 1 is H, LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, R 2', R 2" are independently H, Hal, OH, CN, LA, O, R 3 is H, LA, Hal, OH, SH, S, CN, NO 2, NH 2, O, OCO, COO,NH, NHCOO, N 2, NH 2, NH, SO 2 NH 2, SO 2, or L-Cyc 2, R 4 is H, LA, OH, NH(R 2), O, Cyc 3, R 5 is H, LA, R 4, R 5 together with the atoms they are attached to, can form a 4, 5, 6 or 7 membered heterocycle, having 1 or 2 heteroatoms, which is optionally substituted by R 6, R 6 is H, LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, W is -NR 5 COR 4 or -CON(R 4)(R 5), X is N or CH, Y is O or CH 2, Z is NH, N, S, CH 2, CH, C 2, Cyc 1 is a mono- or binuclear, aliphatic or aromatic, 4, 5, 6, 7, 8, 9 or 10 membered homo- or heterocycle, having 0, 1, 2, 3 or 4 N, O and/or S atoms, which may be substituted by one or two oxo groups, and in which one N atom may be replaced by a N + -O - group, Cyc 2 is a mono- or binuclear, aliphatic or aromatic, 4, 5, 6, 7, 8, 9 or 10 membered homo- or heterocycle, having 0, 1, 2, 3 or 4 N, O and/or S atoms, which may be mono-substituted by an oxo group, S, SO 2 N 3, NHCOH, NHCO, NHCOO, NHSO 2, COO, CONH 2, CONH 2, CONH, L-Cyc 3 or A, or independently mono-, di-, tri- or tetra-substituted by LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, CO, and in which one N atom may be replaced by a N + -O - group, Cyc 3 is a monocyclic, aliphatic or aromatic homo- or heterocycle having 0, 1, 2 or 3 N, N + -O -, O and/or S atoms and 5 or 6 skeleton atoms, which may be mono- or di-substituted by LA, Hal, OH, CN, NO 2, NH 2, O, S, NH, N 2, and in which one N atom may be replaced by a N + -O-group, L is a bond, or a unbranched alkyl or alkenyl linker, having 1, 2 or 3 carbon atoms, in which one CH 2 group may be replaced by a carbonyl group, LA is unbranched or branched alkyl, alkenyl or alkynyl, having 1, 2, 3, 4 or 5 carbon atoms, wherein one, two or three H atoms may be replaced by Hal, A is a unbranched or branched alkyl or alkenyl chain having up to 25 non-hydrogen atoms, wherein 1, 2, 3, 4, 5 or 6 CH 2 groups may be replaced by O, S, NH, CO, N, SO 2, and 1-7 H atoms may be replaced by Hal, and one CH 3 group may be replaced by OH, NH 2 or Cyc 1, Hal is F, Cl, Br or I. R 1 is H, LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, R 2', R 2" are independently H, Hal, OH, CN, LA, O, R 3 is H, LA, Hal, OH, SH, S, CN, NO 2, NH 2, O, OCO, COO,NH, NHCOO, N 2, NH 2, NH, SO 2 NH 2, SO 2, or L-Cyc 2, R 4 is H, LA, OH, NH(R 2), O, Cyc 3, R 5 is H, LA, R 4, R 5 together with the atoms they are attached to, can form a 4, 5, 6 or 7 membered heterocycle, having 1 or 2 heteroatoms, which is optionally substituted by R 6, R 6 is H, LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, W is -NR 5 COR 4 or -CON(R 4)(R 5), X is N or CH, Y is O or CH 2, Z is NH, N, S, CH 2, CH, C 2, Cyc 1 is a mono- or binuclear, aliphatic or aromatic, 4, 5, 6, 7, 8, 9 or 10 membered homo- or heterocycle, having 0, 1, 2, 3 or 4 N, O and/or S atoms, which may be substituted by one or two oxo groups, and in which one N atom may be replaced by a N + -O - group, Cyc 2 is a mono- or binuclear, aliphatic or aromatic, 4, 5, 6, 7, 8, 9 or 10 membered homo- or heterocycle, having 0, 1, 2, 3 or 4 N, O and/or S atoms, which may be mono-substituted by an oxo group, S, SO 2 N 3, NHCOH, NHCO, NHCOO, NHSO 2, COO, CONH 2, CONH 2, CONH, L-Cyc 3 or A, or independently mono-, di-, tri- or tetra-substituted by LA, Hal, OH, CN, NO 2, NH 2, O, NH, N 2, CO, and in which one N atom may be replaced by a N + -O - group, Cyc 3 is a monocyclic, aliphatic or aromatic homo- or heterocycle having 0, 1, 2 or 3 N, N + -O -, O and/or S atoms and 5 or 6 skeleton atoms, which may be mono- or di-substituted by LA, Hal, OH, CN, NO 2, NH 2, O, S, NH, N 2, and in which one N atom may be replaced by a N + -O-group, L is a bond, or a unbranched alkyl or alkenyl linker, having 1, 2 or 3 carbon atoms, in which one CH 2 group may be replaced by a carbonyl group, LA is unbranched or branched alkyl, alkenyl or alkynyl, having 1, 2, 3, 4 or 5 carbon atoms, wherein one, two or three H atoms may be replaced by Hal, A is a unbranched or branched alkyl or alkenyl chain having up to 25 non-hydrogen atoms, wherein 1, 2, 3, 4, 5 or 6 CH 2 groups may be replaced by O, S, NH, CO, N, SO 2, and 1-7 H atoms may be replaced by Hal, and one CH 3 group may be replaced by OH, NH 2 or Cyc 1, Hal is F, Cl, Br or I.