A process for preparing a compound of Formula Ia-1 and salts and solvates thereof, wherein: Z is -C(=O)OR 1; R 1 is hydrogen or C 1 -C 10 alkyl; R 2 is hydrogen; X 1 and X 2 are independently selected from hydrogen, F, Cl, Br, and I; X 5 is F, Cl, Br, or I; and R 10 is C 1 -C 10 alkyl; said method comprising: nitrating a compound having the Formula wherein X 3 and X 4 are independently F, Cl, Br, I, or a sulfonate ester, to provide a compound of Formula II treating said compound of Formula II optionally at elevated temperatures and/or pressure with two or more equivalents of (i) a reagent that contains or generates ammonia, or (ii) a primary amine other than an aromatic amine or (iii) a reagent selected from protected ammonia or amide equivalents, nitrogen nucleophiles having the Formula MNR 2 R 2a wherein M is a metal and metal silylamides, to provide a compound of Formula VI-11 wherein A is -NR 2 R 2a wherein R 2a is hydrogen; reducing said compound of Formula VI-11 to provide a compound of Formula VIIa-1 cyclizing said compound of Formula VII-1 to provide a compound of Formula VIIIa-1 coupling said compound of Formula VIIIa-1 with a reagent having the Formula wherein X 6 is F, Cl, Br, I, -OSO 2 CF 3, alkyl sulfonate, aryl sulfonate, alkylaryl sulfonate, -B(OR 8) 2, -BF 3 or -Bi(R 1) 2, optionally either (i) at elevated temperature and optionally in the presence of a base, or (ii) in the presence of an organometallic catalyst and a base, to provide said compound of Formula Ia-1. Z is -C(=O)OR 1; R 1 is hydrogen or C 1 -C 10 alkyl; R 2 is hydrogen; X 1 and X 2 are independently selected from hydrogen, F, Cl, Br, and I; X 5 is F, Cl, Br, or I; and R 10 is C 1 -C 10 alkyl; said method comprising: nitrating a compound having the Formula wherein X 3 and X 4 are independently F, Cl, Br, I, or a sulfonate ester, to provide a compound of Formula II treating said compound of Formula II optionally at elevated temperatures and/or pressure with two or more equivalents of (i) a reagent that contains or generates ammonia, or (ii) a primary amine other than an aromatic amine or (iii) a reagent selected from protected ammonia or amide equivalents, nitrogen nucleophiles having the Formula MNR 2 R 2a wherein M is a metal and metal silylamides, to provide a compound of Formula VI-11 wherein A is -NR 2 R 2a nitrating a compound having the Formula wherein X 3 and X 4 are independently F, Cl, Br, I, or a sulfonate ester, to provide a compound of Formula II treating said compound of Formula II optionally at elevated temperatures and/or pressure with two or more equivalents of (i) a reagent that contains or generates ammonia, or (ii) a primary amine other than an aromatic amine or (iii) a reagent selected from protected ammonia or amide equivalents, nitrogen nucleophiles having the Formula MNR 2 R 2a wherein M is a metal and metal silylamides, to provide a compound of Formula VI-11 wherein A is -NR 2 R 2a wherein R 2a is hydrogen; reducing said compound of Formula VI-11 to provide a compound of Formula VIIa-1 cyclizing said compound of Formula VII-1 to provide a compound of Formula VIIIa-1 coupling said compound of Formula VIIIa-1 with a reagent having the Formula wherein X 6 is F, Cl, Br, I, -OSO 2 CF 3, alkyl sulfonate, aryl sulfonate, alkylaryl sulfonate, -B(OR 8) 2, -BF 3 or -Bi(R 1) 2, optionally either (i) at elevated temperature and optionally in the presence of a base, or (ii) in the presence of an organometallic catalyst and a base, to provide said compound of Formula Ia-1.