A system configured to deliver a lead to a target site, wherein the target site is the bundle of His, below the tricuspid valve, within the right ventricle, the system comprising: an outer guide catheter having a proximal end, a distal end having a distal tip, a lumen having an opening at the distal tip, and a preformed curve in the distal end of the outer guide catheter; an inner guide catheter having a proximal end, a distal end having a distal tip, a curve along the distal end of the inner guide catheter, a lumen having an opening at the distal tip, at least one electrode, for locating the target site, and at least one conductor in electrical connection with the electrode and extending to the proximal end, the inner guide catheter being moveable within the lumen of the outer guide catheter and extendable from the opening of the lumen at the distal tip of the outer guide catheter; an anchor wire having a proximal end, a distal end, and a fixation element on the distal end of the anchor wire, the anchor wire being moveable within the lumen of the inner guide catheter and extendable from the opening of the lumen at the distal tip of the inner guide catheter, the anchor wire being flexible, the fixation being configured to penetrate tissue of the target site to anchor the anchor wire to the tissue of the target site; and an implantable lead having a proximal end configured to interface with an implantable pulse generator, a distal end, at least one electrode on the distal end of the implantable lead, at least one conductor electrically connected to the at least one electrode and extending to the proximal end of the implantable lead, and a lumen sized to accommodate the anchor wire, the implantable lead being flexible and configured to be advanced over the anchor wire to bring the at least one electrode of the implantable lead in contact with the target site while the anchor wire is anchored to the tissue of the target site and the anchor wire extends within the lumen of the implantable lead. an outer guide catheter having a proximal end, a distal end having a distal tip, a lumen having an opening at the distal tip, and a preformed curve in the distal end of the outer guide catheter; an inner guide catheter having a proximal end, a distal end having a distal tip, a curve along the distal end of the inner guide catheter, a lumen having an opening at the distal tip, at least one electrode, for locating the target site, and at least one conductor in electrical connection with the electrode and extending to the proximal end, the inner guide catheter being moveable within the lumen of the outer guide catheter and extendable from the opening of the lumen at the distal tip of the outer guide catheter; an anchor wire having a proximal end, a distal end, and a fixation element on the distal end of the anchor wire, the anchor wire being moveable within the lumen of the inner guide catheter and extendable from the opening of the lumen at the distal tip of the inner guide catheter, the anchor wire being flexible, the fixation being configured to penetrate tissue of the target site to anchor the anchor wire to the tissue of the target site; and an implantable lead having a proximal end configured to interface with an implantable pulse generator, a distal end, at least one electrode on the distal end of the implantable lead, at least one conductor electrically connected to the at least one electrode and extending to the proximal end of the implantable lead, and a lumen sized to accommodate the anchor wire, the implantable lead being flexible and configured to be advanced over the anchor wire to bring the at least one electrode of the implantable lead in contact with the target site while the anchor wire is anchored to the tissue of the target site and the anchor wire extends within the lumen of the implantable lead.