A system for removal of bacterial biofilm from a target site of a human patient, the system comprising: a biofilm removal endoscope including: a handle; an insertion portion adapted for bodily insertion, the insertion portion forming: an imaging channel formed in a working end of the insertion portion and terminating at a viewing window that facilitates imaging of the target site, and an irrigation channel terminating at a nozzle wherein the endoscope is configured such that pressurized fluid delivered through the irrigation channel is directed by the nozzle away from the viewing window to impinge upon a layer of bacterial biofilm at the target characterized in that the endoscope further includes a controller maintained by the handle; the nozzle is projecting distally beyond the viewing window and coupled with the controller to rotate the nozzle relative to the working end about an axis of the nozzle; the nozzle includes a nozzle body having a V-cut opening; and the nozzle effectuates a fan spray pattern that produces mechanical disruption on a line of tissue at a target site. a biofilm removal endoscope including: a handle; an insertion portion adapted for bodily insertion, the insertion portion forming: an imaging channel formed in a working end of the insertion portion and terminating at a viewing window that facilitates imaging of the target site, and an irrigation channel terminating at a nozzle wherein the endoscope is configured such that pressurized fluid delivered through the irrigation channel is directed by the nozzle away from the viewing window to impinge upon a layer of bacterial biofilm at the target characterized in that the endoscope further includes a controller maintained by the handle; the nozzle is projecting distally beyond the viewing window and coupled with the controller to rotate the nozzle relative to the working end about an axis of the nozzle; the nozzle includes a nozzle body having a V-cut opening; and the nozzle effectuates a fan spray pattern that produces mechanical disruption on a line of tissue at a target site. a handle; an insertion portion adapted for bodily insertion, the insertion portion forming: an imaging channel formed in a working end of the insertion portion and terminating at a viewing window that facilitates imaging of the target site, and an irrigation channel terminating at a nozzle wherein the endoscope is configured such that pressurized fluid delivered through the irrigation channel is directed by the nozzle away from the viewing window to impinge upon a layer of bacterial biofilm at the target characterized in that the endoscope further includes a controller maintained by the handle; the nozzle is projecting distally beyond the viewing window and coupled with the controller to rotate the nozzle relative to the working end about an axis of the nozzle; the nozzle includes a nozzle body having a V-cut opening; and the nozzle effectuates a fan spray pattern that produces mechanical disruption on a line of tissue at a target site. an imaging channel formed in a working end of the insertion portion and terminating at a viewing window that facilitates imaging of the target site, and an irrigation channel terminating at a nozzle wherein the endoscope is configured such that pressurized fluid delivered through the irrigation channel is directed by the nozzle away from the viewing window to impinge upon a layer of bacterial biofilm at the target characterized in that the endoscope further includes a controller maintained by the handle; the nozzle is projecting distally beyond the viewing window and coupled with the controller to rotate the nozzle relative to the working end about an axis of the nozzle; the nozzle includes a nozzle body having a V-cut opening; and the nozzle effectuates a fan spray pattern that produces mechanical disruption on a line of tissue at a target site.