A syringe (111,211,311, 1011), comprising: a body (121, 221, 321, 421, 521, 621, 721, 821, 1021) for receiving a medicament; a collar (141,241,441,541,641,741,921, 941, 981, 1041) rotatably disposed in said body (121, 221,321,421, 521, 621, 721, 821, 1021); a plunger (161, 261, 961, 1061) disposed in and movable with respect to said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041); said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) being rotatable to set a desired dose of the medicament by axially moving said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) with respect to said body (121, 221, 321,421,521,621, 721, 821, 1021) by rotational movement of said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) with respect to said body (121,221,321,421,521,621,721,821, 1021); said plunger (161, 261, 961, 1061) being axially movable with respect to said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) to selectively draw in the medicament according to said set desired dose, and dispense the medicament; a second mechanical stop (149, 245, 1049) being an end of the collar disposed in said body to stop axial movement of said plunger with respect to said body according to a position of said collar with respect to said body when drawing in the medicament, to limit the medicament drawn in to said set desired dose defined by axial movement of said plunger from a first mechanical stop (128, 228, 1028) to said second mechanical stop, characterized in that the first mechanical stop (128, 228, 1028) being a reduced diameter portion of the syringe body disposed in said body to define a position of said plunger with respect to said body before drawing in the medicament. a body (121, 221, 321, 421, 521, 621, 721, 821, 1021) for receiving a medicament; a collar (141,241,441,541,641,741,921, 941, 981, 1041) rotatably disposed in said body (121, 221,321,421, 521, 621, 721, 821, 1021); a plunger (161, 261, 961, 1061) disposed in and movable with respect to said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041); said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) being rotatable to set a desired dose of the medicament by axially moving said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) with respect to said body (121, 221, 321,421,521,621, 721, 821, 1021) by rotational movement of said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) with respect to said body (121,221,321,421,521,621,721,821, 1021); said plunger (161, 261, 961, 1061) being axially movable with respect to said collar (141, 241, 441, 541, 641, 741, 921, 941, 981, 1041) to selectively draw in the medicament according to said set desired dose, and dispense the medicament; a second mechanical stop (149, 245, 1049) being an end of the collar disposed in said body to stop axial movement of said plunger with respect to said body according to a position of said collar with respect to said body when drawing in the medicament, to limit the medicament drawn in to said set desired dose defined by axial movement of said plunger from a first mechanical stop (128, 228, 1028) to said second mechanical stop, characterized in that the first mechanical stop (128, 228, 1028) being a reduced diameter portion of the syringe body disposed in said body to define a position of said plunger with respect to said body before drawing in the medicament.