A centrifugal blood pump system configured to pump blood into a peripheral vein at a blood flow rate between 50 mL/min and 1500 mL/min for at least 7 days, the centrifugal blood pump system comprising: a centrifugal blood pump comprising; a housing (135, 165) defining an inlet and an outlet, the inlet comprising an inflow diffuser to receive the blood and direct blood onto an impeller, the housing having a top bezel and a top bearing pin extending from a top portion of the housing into the inlet, and a bottom bezel and a bottom bearing pin extending from a bottom portion of the housing into an impeller chamber of the housing; the impeller suspended within the housing and configured to contact the top bearing pin and the bottom bearing pin, the impeller including a plurality of blades extending radially from a center of the impeller on a top surface of the impeller; at least one lumen extending parallel to a central axis of the impeller from a bottom surface of the impeller through the impeller to the top surface of the impeller; at least one magnet mechanically engaged to the impeller; and an electric motor to magnetically engage the at least one magnet, wherein the electric motor rotates the at least one magnet and the impeller; an inflow conduit having a first end and a second end, where the first end is configured to make a fluid connection to the inlet of the blood pump and the second end is configured for insertion and advancement in a lumen of a vein; an outflow conduit having a first end and a second end, where the first end is configured to make a fluid connection to the outlet of the blood pump and the second end is configured for making a fluid connection to the peripheral vein; a control system in communication with and configured to monitor the blood pump and one or more sensors, wherein the control system is configured to control a rotational speed of the impeller to adjust the blood flow rate through the blood pump to maintain a mean wall shear stress within the peripheral vein fluidly connected to the outflow conduit of the blood pump in a range of 2.5 to 10.0 Pa, the control system comprising a processor for controlling the rotational speed of the impeller, memory, and a cable for electrically connecting the control system to the blood pump; and a power source comprising a battery. a centrifugal blood pump comprising; a housing (135, 165) defining an inlet and an outlet, the inlet comprising an inflow diffuser to receive the blood and direct blood onto an impeller, the housing having a top bezel and a top bearing pin extending from a top portion of the housing into the inlet, and a bottom bezel and a bottom bearing pin extending from a bottom portion of the housing into an impeller chamber of the housing; the impeller suspended within the housing and configured to contact the top bearing pin and the bottom bearing pin, the impeller including a plurality of blades extending radially from a center of the impeller on a top surface of the impeller; at least one lumen extending parallel to a central axis of the impeller from a bottom surface of the impeller through the impeller to the top surface of the impeller; at least one magnet mechanically engaged to the impeller; and an electric motor to magnetically engage the at least one magnet, wherein the electric motor rotates the at least one magnet and the impeller; a housing (135, 165) defining an inlet and an outlet, the inlet comprising an inflow diffuser to receive the blood and direct blood onto an impeller, the housing having a top bezel and a top bearing pin extending from a top portion of the housing into the inlet, and a bottom bezel and a bottom bearing pin extending from a bottom portion of the housing into an impeller chamber of the housing; the impeller suspended within the housing and configured to contact the top bearing pin and the bottom bearing pin, the impeller including a plurality of blades extending radially from a center of the impeller on a top surface of the impeller; at least one lumen extending parallel to a central axis of the impeller from a bottom surface of the impeller through the impeller to the top surface of the impeller; at least one magnet mechanically engaged to the impeller; and an electric motor to magnetically engage the at least one magnet, wherein the electric motor rotates the at least one magnet and the impeller; an inflow conduit having a first end and a second end, where the first end is configured to make a fluid connection to the inlet of the blood pump and the second end is configured for insertion and advancement in a lumen of a vein; an outflow conduit having a first end and a second end, where the first end is configured to make a fluid connection to the outlet of the blood pump and the second end is configured for making a fluid connection to the peripheral vein; a control system in communication with and configured to monitor the blood pump and one or more sensors, wherein the control system is configured to control a rotational speed of the impeller to adjust the blood flow rate through the blood pump to maintain a mean wall shear stress within the peripheral vein fluidly connected to the outflow conduit of the blood pump in a range of 2.5 to 10.0 Pa, the control system comprising a processor for controlling the rotational speed of the impeller, memory, and a cable for electrically connecting the control system to the blood pump; and a power source comprising a battery.