A method of immunoassay to measure neo-epitope containing protein fragments naturally present in a body fluid sample, wherein said immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with an N-terminal neo-epitope formed by cleavage of a protein by a proteinase or a C-terminal neo-epitope formed by cleavage of a protein by a proteinase, which immunological binding partner is non-reactive with the intact protein from which the epitope derives and is not reactive with a prolongated version of the neo-epitope sequence in which the neo-epitope sequence is prolonged past the cleavage site, and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, wherein said immunological binding partner specifically binds a neo-epitope constituted by an N-terminal amino acid sequence present in peptides produced by cleavage of collagen type I, said peptides comprising an N-terminal sequence selected from the group consisting of: Collagen I, alpha1 ISVPGP... SEQ ID NO23 VPGPMG... SEQ ID NO24 PGPMGP... SEQ ID NO25 FQGPPG... SEQ ID NO27 KNGDDG... SEQ ID NO28 ARGLPG... SEQ ID NO29 LDGAKG... SEQ ID NO31 LPGERG... SEQ ID NO32 ATGAAG... SEQ ID NO67 VRGEPG... SEQ ID NO33 PGAKGA... SEQ ID NO34 GIAGAP... SEQ ID NO69 GGPPGP... SEQ ID NO35 NSGEPG... SEQ ID NO36 VQGPPG... SEQ ID NO71 DGVAGP... SEQ ID NO37 ERGSPG... SEQ ID NO38 RGSPGP... SEQ ID NO74 LTGSPG... SEQ ID NO39 QDGRPG... SEQ ID NO40 ARGQAG... SEQ ID NO77 RGVPGP... SEQ ID NO41 VGPAGK... SEQ ID NO42 KDGEAG... SEQ ID NO80 ERGEQG... SEQ ID NO43 RGEQGP... SEQ ID NO44 QGLPGP... SEQ ID NO83 PGERGV... SEQ ID NO45 ANGAPG... SEQ ID NO46 AGLPGP... SEQ ID NO86 ARGAPG... SEQ ID NO47 PGDRGE... SEQ ID NO48 FAGPPG... SEQ ID NO75 AKGDAG... SEQ ID NO49 PIGNVG... SEQ ID NO50 NVGAPG... SEQ ID NO78 AAGRVG... SEQ ID NO51 PPGPAG... SEQ ID NO52 GEVGPP... SEQ ID NO81 GADGPA... SEQ ID NO53 GPQGIA... SEQ ID NO54 IAGQRG... SEQ ID NO84 GQRGVV... SEQ ID NO55 QRGVVG... SEQ ID NO56 RGVVGL... SEQ ID NO87 GLPGQR... SEQ ID NO57 PGLPGP... SEQ ID NO58 EPGKQG... SEQ ID NO90 PMGPPG... SEQ ID NO59 MGPPGL... SEQ ID NO60 LAGPPG... SEQ ID NO89 DKGETG... SEQ ID NO61 LQGPPG... SEQ ID NO62 PSGASG... SEQ ID NO92 SAGAPG... SEQ ID NO63 RTGDAG... SEQ ID NO64 VGPPGP... SEQ ID NO99 FDFSF... SEQ ID NO65 DFSF... SEQ ID NO66 AGQRGV... SEQ ID NO95 LPGPGG... SEQ ID NO26 QAGVMG... SEQ ID NO76 VVGLPG... SEQ ID NO98 SGLDGA... SEQ ID NO30 PAGERG... SEQ ID NO79 GKQGPS... SEQ ID NO93 AKGEAG... SEQ ID NO68 ARGERG... SEQ ID NO82 ARGPAG... SEQ ID NO96 IAGAPG... SEQ ID NO70 LTGPIG... SEQ ID NO85 ASGPAG... SEQ ID NO97 LPGPPG... SEQ ID NO72 AGPPGA... SEQ ID NO88 GPPGPP... SEQ ID NO100 AGPKGS... SEQ ID NO73 ATGFPG... SEQ ID NO91 GPPGPA... SEQ ID NO94 or wherein said immunological binding partner specifically binds a neo-epitope constituted by a C-terminal amino acid sequence present in peptides produced by cleavage of collagen type I, said peptides comprising an C-terminal sequence selected from the group consisting of: Collagen I, alpha1...QLSYGY SEQ ID N0101...EKSTGG SEQ ID NO102...PPGPQG SEQ ID NO103...KGHRGF SEQ ID NO104...PSGPRG SEQ ID NO105...APGPQG SEQ ID NO106...APGPAG SEQ ID NO107...FPGAVG SEQ ID NO108...SEGPQG SEQ ID NO109...GANGAP SEQ ID NO110...ANGAPG SEQ ID NO46...SGPQGP SEQ ID NO112...EPGPVG SEQ ID NO113...EPGPTG SEQ ID NO114...RGFPGA SEQ ID NO115...KGPAGE SEQ ID NO116...RGSPGP SEQ ID NO74...LPGAKG SEQ ID NO118...AVGPAG SEQ ID NO122...PPGARG SEQ ID NO120...PGKAGE SEQ ID NO121...APGPDG SEQ ID NO125...PAGPAG SEQ ID NO123...AGPAGE SEQ ID NO124...KDGVRG SEQ ID NO128...RGERGF SEQ ID NO126...PAGPRG SEQ ID NO127...PGPAGF SEQ ID NO131...PAGPTG SEQ ID NO129...TGARGA SEQ ID NO130...SAGPPG SEQ ID NO134...EPGDAG SEQ ID NO132...PAGPPG SEQ ID NO133...GEVGPP SEQ ID NO81...ATGFPG SEQ ID NO91...NAGPPG SEQ ID NO136...PGPQGI SEQ ID NO140...GEKGSP SEQ ID 138...GAPGTP SEQ ID NO139...IAGQRG SEQ ID NO84...GPQGIA SEQ ID NO54...PQGIAG SEQ ID NO142...GPSGEP SEQ ID NO146...GQRGVV SEQ ID NO55...RGERGF SEQ ID NO126...PVGPVG SEQ ID NO149...ERGPPG SEQ ID NO147...RGPPGP SEQ ID NO148...EQGPSG SEQ ID NO152...PQGPRG SEQ ID 150...HRGFSG SEQ ID NO151...GPPGPP SEQ ID NO100...PRGPPG SEQ ID NO153...PPGPRG SEQ ID NO154...PPGPPG SEQ ID NO119...GPPSAG SEQ ID NO156...PPSAGF SEQ ID NO157...QMGPRG SEQ ID NO161...PPGPAG SEQ ID NO52...TPGPQG SEQ ID NO160...PGADGQ SEQ ID NO164...PGPPGA SEQ ID 162...QGIAGQ SEQ ID 163...PPGPKG SEQ ID NO167...AGSPGF SEQ ID NO165...LPGPSG SEQ ID NO166...PKGPAG SEQ ID NO170...PGERGA SEQ ID NO168...PMGPPG SEQ ID NO59...GPAGRP SEQ ID NO173...PPGPIG SEQ ID NO174...SPGEQG SEQ ID NO172...TGDAGP SEQ ID NO175