A needle-free connector (100, 100A, 100B) adapted to be connected to a syringe, the needle-free connector (100, 100A, 100B) comprising: a guiding base comprising a conduit, the conduit extending downward along an axial direction; a connecting base disposed on the guiding base and comprising a screw portion and a passage running through the screw portion, a chamber being formed between the guiding base and the connecting base, and the conduit and the passage respectively communicating with the chamber along the axial direction; a valve member disposed between the guiding base and the connecting base and movably located in the chamber; and a seal member disposed at an end of the valve member away from the conduit, wherein the seal member and the valve member are connected with each other, wherein the seal member has a water breaking portion disposed on a top surface, facing the passage, of the seal member, wherein the water breaking portion is higher than the top surface T of the seal member, wherein the seal member is used for sealing the passage of the connecting base, when the syringe penetrates from the passage, the seal member is pushed to drive the valve member to move downward, so that the seal member is displaced into the chamber to unseal the passage, a liquid medicine is adapted to flow into the chamber through the syringe, and when the syringe is separated from the passage, the valve member is adapted to drive the seal member to upward move to an initial position, the needle-free connector (100, 100A, 100B) being characterized in that the valve member comprises a support portion, a flow-through portion, and an elastic portion, the support portion is disposed in the connecting base and is connected to the seal member, the flow-through portion is disposed in the guiding base and is aligned with the conduit, the elastic portion is disposed between the support portion and the flow-through portion, and the elastic portion is adapted to outward push the support portion and the flow-through portion, and that the support portion has a locking block, the seal member has a groove, and the locking block is disposed in the groove to connect the support portion and the seal member into a whole. a guiding base comprising a conduit, the conduit extending downward along an axial direction; a connecting base disposed on the guiding base and comprising a screw portion and a passage running through the screw portion, a chamber being formed between the guiding base and the connecting base, and the conduit and the passage respectively communicating with the chamber along the axial direction; a valve member disposed between the guiding base and the connecting base and movably located in the chamber; and a seal member disposed at an end of the valve member away from the conduit, wherein the seal member and the valve member are connected with each other, wherein the seal member has a water breaking portion disposed on a top surface, facing the passage, of the seal member, wherein the water breaking portion is higher than the top surface T of the seal member, wherein the seal member is used for sealing the passage of the connecting base, when the syringe penetrates from the passage, the seal member is pushed to drive the valve member to move downward, so that the seal member is displaced into the chamber to unseal the passage, a liquid medicine is adapted to flow into the chamber through the syringe, and when the syringe is separated from the passage, the valve member is adapted to drive the seal member to upward move to an initial position, the needle-free connector (100, 100A, 100B) being characterized in that the valve member comprises a support portion, a flow-through portion, and an elastic portion, the support portion is disposed in the connecting base and is connected to the seal member, the flow-through portion is disposed in the guiding base and is aligned with the conduit, the elastic portion is disposed between the support portion and the flow-through portion, and the elastic portion is adapted to outward push the support portion and the flow-through portion, and that the support portion has a locking block, the seal member has a groove, and the locking block is disposed in the groove to connect the support portion and the seal member into a whole.