A compound, or salt or tautomer thereof, according to Formula: Wherein n is 0, 1 or 2; R is hydrogen, C 1 -C 4 alkyl, or hydroxyC 1 -C 4 alkyl; R 1 is halogen, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, aminoC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, C 3 -C 6 cycloalkyC 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, -S p C 1 -C 6 alkyl, -CH 2 NHC C 1 -C 4 alkyl or -OCH 2 C R 7, p is 0, 1, or 2; R 2 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyC 1 -C 6 alkyl or halogen; R 3 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, -CH 2 C R 7, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups, and wherein alkyl and haloalkyl optionally substituted with 0 or 1 hydroxy; R 4 is phenyl, naphthyl or heteroaryl, where the heteroaryl is a five or six member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, and where the phenyl or heteroaryl is optionally substituted by R 5 and further substituted by 0 or 1 substituents selected from halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy C 1 -C 4 alkyl, hydroxy, and cyanomethyl; R 5 is -C R 8, -CH 2 C R 8, R 9, -C NHSO 2 C 1 -C 4 alkyl, -SO 2 NHC C 1 -C 4 alkyl,-SO 2 N m (C 1 -C 4 alkyl) 2-m, -SO 2 C 1 -C 4 alkyl, cyano, halogen, hydroxyC 1 -C 4 alkyl and 5 member heteroaryl having 1-4 ring nitrogen atoms and 0 or 1 ring sulfur or oxygen atoms; m is 0, 1, or 2; W is O or C(R 6) 2; R 6 is independently selected at each occurrence from the group consisting of hydrogen, hydroxy, amino, mono- and di- C 1 -C 4 alkylamino, C 1 -C 4 alkyl, hydroxyC 1 -C 4 alkyl, cyanoC 1 -C 4 alkyl or C 1 -C 4 alkoxy; or C(R 6) 2, taken in combination, form a spirocyclic carbocycle having 3 to 6 ring atoms; R 7 is hydroxy, C 1 -C 4 alkoxy, amino or mono- and di-C 1 -C 4 alkylamino; R 8 is hydroxy, C 1 -C 4 alkoxy, amino or a 5 to 7 member saturated heterocycle having 1, 2, or 3 ring heteroatoms independently selected from N, O or S; or R 8 is mono- and di-C 1 -C 4 alkylamino which is unsubstituted or substituted with halogen, hydroxy or C 1 -C 4 alkyl; and R 9 is a 5 membered heteroaryl having 1 to 4 ring nitrogen atoms and 0 or 1 ring oxygen or sulfur atoms, which heterocycle is optionally substituted by 0 to 2 C 1 -C 4 alkyl groups. n is 0, 1 or 2; R is hydrogen, C 1 -C 4 alkyl, or hydroxyC 1 -C 4 alkyl; R 1 is halogen, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, haloC 1 -C 6 alkyl, hydroxyC 1 -C 6 alkyl, aminoC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkoxy, C 3 -C 6 cycloalkyC 1 -C 6 alkoxy, haloC 1 -C 6 alkoxy, -S p C 1 -C 6 alkyl, -CH 2 NHC C 1 -C 4 alkyl or -OCH 2 C R 7, p is 0, 1, or 2; R 2 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxyC 1 -C 6 alkyl or halogen; R 3 is hydrogen, halogen, cyano, C 1 -C 4 alkyl, haloC 1 -C 4 alkyl, -CH 2 C R 7, phenyl or 5 or 6 member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1, or 2 C 1 -C 4 alkyl groups, and wherein alkyl and haloalkyl optionally substituted with 0 or 1 hydroxy; R 4 is phenyl, naphthyl or heteroaryl, where the heteroaryl is a five or six member heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, and where the phenyl or heteroaryl is optionally substituted by R 5 and further substituted by 0 or 1 substituents selected from halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy C 1 -C 4 alkyl, hydroxy, and cyanomethyl; R 5 is -C R 8, -CH 2 C R 8, R 9, -C NHSO 2 C 1 -C 4 alkyl, -SO 2 NHC C 1 -C 4 alkyl,-SO 2 N m (C 1 -C 4 alkyl) 2-m, -SO 2 C 1 -C 4 alkyl, cyano, halogen, hydroxyC 1 -C 4 alkyl and 5 member heteroaryl having 1-4 ring nitrogen atoms and 0 or 1 ring sulfur or oxygen atoms; m is 0, 1, or 2; W is O or C(R 6) 2; R 6 is independently selected at each occurrence from the group consisting of hydrogen, hydroxy, amino, mono- and di- C 1 -C 4 alkylamino, C 1 -C 4 alkyl, hydroxyC 1 -C 4 alkyl, cyanoC 1 -C 4 alkyl or C 1 -C 4 alkoxy; or C(R 6) 2, taken in combination, form a spirocyclic carbocycle having 3 to 6 ring atoms; R 7 is hydroxy, C 1 -C 4 alkoxy, amino or mono- and di-C 1 -C 4 alkylamino; R 8 is hydroxy, C 1 -C 4 alkoxy, amino or a 5 to 7 member saturated heterocycle having 1, 2, or 3 ring heteroatoms independently selected from N, O or S; or R 8 is mono- and di-C 1 -C 4 alkylamino which is unsubstituted or substituted with halogen, hydroxy or C 1 -C 4 alkyl; and R 9 is a 5 membered heteroaryl having 1 to 4 ring nitrogen atoms and 0 or 1 ring oxygen or sulfur atoms, which heterocycle is optionally substituted by 0 to 2 C 1 -C 4 alkyl groups.