A reloadable system (100, 200, 300, 400) for treating tissue, comprising: a clip assembly (102, 202, 302) including a pair of clip arms (118, 418), each of the clip arms (118, 418) extending from a proximal end to a distal end, the proximal end of each of the clip arms (118, 418) being slidably received within a channel of a capsule (124, 224, 324) to be moved between a tissue receiving configuration, in which distal ends of the clip arms (118, 418) are biased so as to be separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms (118, 418) are moved toward one another and constrained by the capsule (124, 224, 324); a cartridge including a groove therein, the groove sized and shaped for housing the clip assembly (102, 202, 302), the cartridge including a proximal opening open to an exterior of the cartridge in communication with the groove; and an applicator (104, 204, 304, 404) having a distal portion insertable through the opening of the cartridge to be releasably coupled to the clip assembly (102, 202, 302) to move the clip assembly (102, 202, 302) between the tissue receiving configuration and the tissue clipping configuration, the applicator (104, 204, 304, 404) including a control member (150, 250, 350) connectable to the proximal end of each of the clip arms (118, 418) and a locking sleeve (108, 208, 308) coupleable to a proximal end of the capsule (124, 224, 324) via a deflectable tab (184, 284, 384) defined along a length of the locking sleeve (108, 208, 308) from a free distal end to a proximal end connected to the remaining portion of the locking sleeve (108, 208, 308) so that the deflectable tab (184, 284, 384) is deflectable relative to the remaining portion, the deflectable tab (184, 284, 384) including an engaging structure (110, 210, 310) configured to engage a corresponding engaging structure (160, 260, 360) at the proximal end of the capsule (124, 224, 324); characterized in that the deflectable tab (184, 284; 324) includes a releasing structure (114, 214) proximal of the engaging structure (110, 210, 310), the releasing structure being engageable with a portion of the control member (150, 250, 350) to deflect the deflectable tab and disengage the engaging structure (110, 210, 310) of the locking sleeve (108, 208, 308) from the corresponding engaging structure (160, 260, 360) of the capsule (124, 224, 324). a clip assembly (102, 202, 302) including a pair of clip arms (118, 418), each of the clip arms (118, 418) extending from a proximal end to a distal end, the proximal end of each of the clip arms (118, 418) being slidably received within a channel of a capsule (124, 224, 324) to be moved between a tissue receiving configuration, in which distal ends of the clip arms (118, 418) are biased so as to be separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms (118, 418) are moved toward one another and constrained by the capsule (124, 224, 324); a cartridge including a groove therein, the groove sized and shaped for housing the clip assembly (102, 202, 302), the cartridge including a proximal opening open to an exterior of the cartridge in communication with the groove; and an applicator (104, 204, 304, 404) having a distal portion insertable through the opening of the cartridge to be releasably coupled to the clip assembly (102, 202, 302) to move the clip assembly (102, 202, 302) between the tissue receiving configuration and the tissue clipping configuration, the applicator (104, 204, 304, 404) including a control member (150, 250, 350) connectable to the proximal end of each of the clip arms (118, 418) and a locking sleeve (108, 208, 308) coupleable to a proximal end of the capsule (124, 224, 324) via a deflectable tab (184, 284, 384) defined along a length of the locking sleeve (108, 208, 308) from a free distal end to a proximal end connected to the remaining portion of the locking sleeve (108, 208, 308) so that the deflectable tab (184, 284, 384) is deflectable relative to the remaining portion, the deflectable tab (184, 284, 384) including an engaging structure (110, 210, 310) configured to engage a corresponding engaging structure (160, 260, 360) at the proximal end of the capsule (124, 224, 324); characterized in that the deflectable tab (184, 284; 324) includes a releasing structure (114, 214) proximal of the engaging structure (110, 210, 310), the releasing structure being engageable with a portion of the control member (150, 250, 350) to deflect the deflectable tab and disengage the engaging structure (110, 210, 310) of the locking sleeve (108, 208, 308) from the corresponding engaging structure (160, 260, 360) of the capsule (124, 224, 324).