A microscope arrangement comprising: a microscope; a switching arrangement; a beam splitter; optical elements (28, 30) for generating partial beam paths, the partial beam paths including a first partial beam path and a second partial beam path; and at least two optical detectors, the at least two optical detectors including a first optical detector and a second optical detector; characterized in that: the microscope has at least one optical output port for outputting a fluorescence signal; the switching arrangement is configured to switch the fluorescence signal between the partial beam paths; the optical elements are arranged such that the ends of the first and second partial beam paths are superimposed at the beam splitter; and the first detector and the second detector are arranged with respect to the beam splitter such that: when the fluorescence signal is transmitted along the first partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the first optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the second optical detector, and when the fluorescence signal is transmitted along the second partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the second optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the first optical detector. a microscope; a switching arrangement; a beam splitter; optical elements (28, 30) for generating partial beam paths, the partial beam paths including a first partial beam path and a second partial beam path; and at least two optical detectors, the at least two optical detectors including a first optical detector and a second optical detector; characterized in that: the microscope has at least one optical output port for outputting a fluorescence signal; the switching arrangement is configured to switch the fluorescence signal between the partial beam paths; the optical elements are arranged such that the ends of the first and second partial beam paths are superimposed at the beam splitter; and the first detector and the second detector are arranged with respect to the beam splitter such that: when the fluorescence signal is transmitted along the first partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the first optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the second optical detector, and when the fluorescence signal is transmitted along the second partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the second optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the first optical detector. the microscope has at least one optical output port for outputting a fluorescence signal; the switching arrangement is configured to switch the fluorescence signal between the partial beam paths; the optical elements are arranged such that the ends of the first and second partial beam paths are superimposed at the beam splitter; and the first detector and the second detector are arranged with respect to the beam splitter such that: when the fluorescence signal is transmitted along the first partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the first optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the second optical detector, and when the fluorescence signal is transmitted along the second partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the second optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the first optical detector. when the fluorescence signal is transmitted along the first partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the first optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the second optical detector, and when the fluorescence signal is transmitted along the second partial beam path, the portion of the fluorescence signal passing through the beam splitter is received by the second optical detector and the portion of the fluorescence signal reflected by the beam splitter is received by the first optical detector.