Lipid nanostructured system which comprises nanoparticles which in turn comprise: a. A gelled core comprising an aqueous dissolution, solution or dispersion comprising a temperature responsive polymer that becomes gel in function of the temperature, and which further comprises one or more enzymes, preferably lysosomal enzymes, or other proteins with activity on cellular metabolism, immobilized in the core; b. A lipid layer coating the inner core comprising a mixture of: i. a solid lipid, solid or waxy at room temperature, i.e. 25°C at 101.3 kPa, comprising fatty acids, preferably long chain, with a fusion process that begins (onset temperature) at temperatures above 35°C, as determined by differential scanning calorimetry, with an HLB value lower than 10 and densities between 0.8 and 1 g/cm 3, or a mixture of such solid lipids, and ii. a lipid which behaves as a liquid at room temperature, constituted by fatty acids, preferably short chain, with a fusion process that begins (onset temperature) at temperatures below 30°C, as determined by differential scanning calorimetry, and densities ranging from 0.88 to 0.97 g/cm 3, where the mixture of liquid lipid and solid lipid presents a fusion process that begins (onset temperature) at temperatures between 20°C and below 50°C determined by differential scanning calorimetry, wherein the mixture of solid and liquid lipids are mixed in a ratio (liquid lipid: solid lipid) 98: 2 to 1: 99%, where such ratios are expressed as a percentage by weight of solid and liquid lipids with respect to the total lipid composition of the lipid layer coating the inner core; wherein such lipid layer also comprises lipid soluble or dispersible surfactants; wherein such lipid soluble or lipid dispersible surfactants, are selected from among surface-active molecules with HLB values lower than 10; and c. A pegylated coating of the lipid layer that also comprises water soluble or water dispersible surfactants, wherein said pegylated coating comprises polyethylene glycol, or PEG esters and the water soluble or water dispersible surfactants have a HLB greater than 10. a. A gelled core comprising an aqueous dissolution, solution or dispersion comprising a temperature responsive polymer that becomes gel in function of the temperature, and which further comprises one or more enzymes, preferably lysosomal enzymes, or other proteins with activity on cellular metabolism, immobilized in the core; b. A lipid layer coating the inner core comprising a mixture of: i. a solid lipid, solid or waxy at room temperature, i.e. 25°C at 101.3 kPa, comprising fatty acids, preferably long chain, with a fusion process that begins (onset temperature) at temperatures above 35°C, as determined by differential scanning calorimetry, with an HLB value lower than 10 and densities between 0.8 and 1 g/cm 3, or a mixture of such solid lipids, and ii. a lipid which behaves as a liquid at room temperature, constituted by fatty acids, preferably short chain, with a fusion process that begins (onset temperature) at temperatures below 30°C, as determined by differential scanning calorimetry, and densities ranging from 0.88 to 0.97 g/cm 3, where the mixture of liquid lipid and solid lipid presents a fusion process that begins (onset temperature) at temperatures between 20°C and below 50°C determined by differential scanning calorimetry, wherein the mixture of solid and liquid lipids are mixed in a ratio (liquid lipid: solid lipid) 98: 2 to 1: 99%, where such ratios are expressed as a percentage by weight of solid and liquid lipids with respect to the total lipid composition of the lipid layer coating the inner core; wherein such lipid layer also comprises lipid soluble or dispersible surfactants; wherein such lipid soluble or lipid dispersible surfactants, are selected from among surface-active molecules with HLB values lower than 10; and i. a solid lipid, solid or waxy at room temperature, i.e. 25°C at 101.3 kPa, comprising fatty acids, preferably long chain, with a fusion process that begins (onset temperature) at temperatures above 35°C, as determined by differential scanning calorimetry, with an HLB value lower than 10 and densities between 0.8 and 1 g/cm 3, or a mixture of such solid lipids, and ii. a lipid which behaves as a liquid at room temperature, constituted by fatty acids, preferably short chain, with a fusion process that begins (onset temperature) at temperatures below 30°C, as determined by differential scanning calorimetry, and densities ranging from 0.88 to 0.97 g/cm 3, where the mixture of liquid lipid and solid lipid presents a fusion process that begins (onset temperature) at temperatures between 20°C and below 50°C determined by differential scanning calorimetry, wherein the mixture of solid and liquid lipids are mixed in a ratio (liquid lipid: solid lipid) 98: 2 to 1: 99%, where such ratios are expressed as a percentage by weight of solid and liquid lipids with respect to the total lipid composition of the lipid layer coating the inner core; wherein such lipid layer also comprises lipid soluble or dispersible surfactants; wherein such lipid soluble or lipid dispersible surfactants, are selected from among surface-active molecules with HLB values lower than 10; and c. A pegylated coating of the lipid layer that also comprises water soluble or water dispersible surfactants, wherein said pegylated coating comprises polyethylene glycol, or PEG esters and the water soluble or water dispersible surfactants have a HLB greater than 10.