A system for planning and executing focused-ultrasound treatment of a target tissue within a tissue region comprising a plurality of subregions, the system comprising: a processor; and memory storing (i) data descriptive of a model of the tissue region and at least one treatment constraint, (ii) a treatment plan for treating a first subregion of the target tissue, the treatment plan specifying (i) a focus pattern and (ii) temporally variable ultrasound stimuli to be applied sequentially along the focus pattern, and (iii) instructions which, when executed by the processor, cause the processor to (a) simulate treatment on the first subregion in accordance with the stored treatment plan at least in part by computationally traversing the focus pattern associated with the first subregion and computationally applying the temporally variable ultrasound stimuli thereto; (b) computationally predict an effect of the simulated treatment on the first subregion based on the data descriptive of the model of the tissue region and a physical model modeling propagation of the effect through the tissue; (c) compare the predicted effect against the at least one stored treatment constraint; (d) if the at least one treatment constraint is violated, (i) alter the treatment plan by altering the focus pattern and/or at least one of the ultrasound stimuli, and (ii) repeat steps (a) through (d) for the altered treatment plan; (e) electronically store a treatment plan for treating a subsequent subregion of the target tissue, and (f) successively carry out steps (a) through (e) for a plurality of subsequent subregions of the target tissue taking into account the propagation of the effect on the simulated treatment on other subregions, wherein the system further comprises: a treatment apparatus comprising an ultrasound transducer comprising a one- or two-dimensional arrangement of transducer elements configured to carry out focused-ultrasound treatment in accordance with the treatment plan for the first and subsequent subregions. a processor; and memory storing (i) data descriptive of a model of the tissue region and at least one treatment constraint, (ii) a treatment plan for treating a first subregion of the target tissue, the treatment plan specifying (i) a focus pattern and (ii) temporally variable ultrasound stimuli to be applied sequentially along the focus pattern, and (iii) instructions which, when executed by the processor, cause the processor to (a) simulate treatment on the first subregion in accordance with the stored treatment plan at least in part by computationally traversing the focus pattern associated with the first subregion and computationally applying the temporally variable ultrasound stimuli thereto; (b) computationally predict an effect of the simulated treatment on the first subregion based on the data descriptive of the model of the tissue region and a physical model modeling propagation of the effect through the tissue; (c) compare the predicted effect against the at least one stored treatment constraint; (d) if the at least one treatment constraint is violated, (i) alter the treatment plan by altering the focus pattern and/or at least one of the ultrasound stimuli, and (ii) repeat steps (a) through (d) for the altered treatment plan; (e) electronically store a treatment plan for treating a subsequent subregion of the target tissue, and (f) successively carry out steps (a) through (e) for a plurality of subsequent subregions of the target tissue taking into account the propagation of the effect on the simulated treatment on other subregions, (a) simulate treatment on the first subregion in accordance with the stored treatment plan at least in part by computationally traversing the focus pattern associated with the first subregion and computationally applying the temporally variable ultrasound stimuli thereto; (b) computationally predict an effect of the simulated treatment on the first subregion based on the data descriptive of the model of the tissue region and a physical model modeling propagation of the effect through the tissue; (c) compare the predicted effect against the at least one stored treatment constraint; (d) if the at least one treatment constraint is violated, (i) alter the treatment plan by altering the focus pattern and/or at least one of the ultrasound stimuli, and (ii) repeat steps (a) through (d) for the altered treatment plan; (e) electronically store a treatment plan for treating a subsequent subregion of the target tissue, and (f) successively carry out steps (a) through (e) for a plurality of subsequent subregions of the target tissue taking into account the propagation of the effect on the simulated treatment on other subregions, wherein the system further comprises: a treatment apparatus comprising an ultrasound transducer comprising a one- or two-dimensional arrangement of transducer elements configured to carry out focused-ultrasound treatment in accordance with the treatment plan for the first and subsequent subregions.