A driving circuit for a piezoelectrically actuated pump, wherein the piezoelectrically actuated pump is driven by a piezoelectric actuator load, the driving circuit comprising: the piezoelectric actuator load; a boost converter receiving an input voltage (V in) and converting the input voltage (V in) into a constant voltage (V cc); a control circuit comprising a voltage-division circuit electrically connected with the piezoelectric actuator load for receiving a minor voltage (V C) outputted from the piezoelectric actuator load, a comparator and a frequency adjustment circuit, wherein the constant voltage (V cc) is divided into a first voltage (V 1) and a second voltage (V 2) by the voltage-division circuit, and the comparator compares the first voltage (V 1) with the second voltage (V 2) and outputs a positive voltage (V+) or a negative voltage (V-) according to a comparing result; and a voltage switch circuit electrically connected with the control circuit, receiving the positive voltage (V+) or the negative voltage (V-) outputted from the comparator, and comprising a half-bridge circuit comprising a first switch element and a second switch element, wherein the voltage switch circuit receives the positive voltage (V+) or the negative voltage (V-) outputted from the comparator and feedbacks the positive voltage (V+) or the negative voltage (V-) to the piezoelectric actuator load so as to form a required positive voltage or a required negative voltage; wherein the control circuit and the voltage switch circuit form a resonant circuit to control the operation of the piezoelectric actuator load according to the variety of the minor voltage (V c) outputted from the piezoelectric actuator load, and the frequency adjustment circuit of the control circuit detects and adjusts the variety of the minor voltage (V c) outputted from the piezoelectric actuator load automatically so as to adjust an operating frequency of the piezoelectric actuator load to a required operating frequency, wherein the frequency adjustment circuit comprises a first resistor and a first capacitor connected in parallel with each other, one terminal of the frequency adjustment circuit receives the constant voltage (V cc) outputted from the boost converter while the other terminal of the frequency adjustment circuit is electrically connected with the voltage-division circuit. the piezoelectric actuator load; a boost converter receiving an input voltage (V in) and converting the input voltage (V in) into a constant voltage (V cc); a control circuit comprising a voltage-division circuit electrically connected with the piezoelectric actuator load for receiving a minor voltage (V C) outputted from the piezoelectric actuator load, a comparator and a frequency adjustment circuit, wherein the constant voltage (V cc) is divided into a first voltage (V 1) and a second voltage (V 2) by the voltage-division circuit, and the comparator compares the first voltage (V 1) with the second voltage (V 2) and outputs a positive voltage (V+) or a negative voltage (V-) according to a comparing result; and a voltage switch circuit electrically connected with the control circuit, receiving the positive voltage (V+) or the negative voltage (V-) outputted from the comparator, and comprising a half-bridge circuit comprising a first switch element and a second switch element, wherein the voltage switch circuit receives the positive voltage (V+) or the negative voltage (V-) outputted from the comparator and feedbacks the positive voltage (V+) or the negative voltage (V-) to the piezoelectric actuator load so as to form a required positive voltage or a required negative voltage; wherein the control circuit and the voltage switch circuit form a resonant circuit to control the operation of the piezoelectric actuator load according to the variety of the minor voltage (V c) outputted from the piezoelectric actuator load, and the frequency adjustment circuit of the control circuit detects and adjusts the variety of the minor voltage (V c) outputted from the piezoelectric actuator load automatically so as to adjust an operating frequency of the piezoelectric actuator load to a required operating frequency, wherein the frequency adjustment circuit comprises a first resistor and a first capacitor connected in parallel with each other, one terminal of the frequency adjustment circuit receives the constant voltage (V cc) outputted from the boost converter while the other terminal of the frequency adjustment circuit is electrically connected with the voltage-division circuit.