mhurhangee/ep-ind-claims huggingface dataset:
A method of identifying cancer which may be susceptible to treatment by the inhibition of PRMT5 which comprises the steps of: (i) contacting a biological sample from a patient with an antibody which specifically binds to arginine-methylated E2F-1 protein, or an epitope-binding fragment of said antibody, (ii) measuring the binding of said antibody or epitope-binding fragment to cells in the biological sample, and (iii) comparing the binding in part (ii) with that of a normal reference subject or standard, wherein an increase in binding compared to that of the normal reference subject or standard indicates susceptibility to treatment by the inhibition of PRMT5. (i) contacting a biological sample from a patient with an antibody which specifically binds to arginine-methylated E2F-1 protein, or an epitope-binding fragment of said antibody, (ii) measuring the binding of said antibody or epitope-binding fragment to cells in the biological sample, and (iii) comparing the binding in part (ii) with that of a normal reference subject or standard, wherein an increase in binding compared to that of the normal reference subject or standard indicates susceptibility to treatment by the inhibition of PRMT5.
A fill up tool (100;200) for insertion into casing, comprising: a mandrel (105;205); a primary sealing member (150;255) disposed on the mandrel for forming a seal with the casing, the primary sealing member being operable by an increase in internal pressure in the fill up tool; characterised by: a selectively operable secondary sealing member for forming a secondary seal with the casing, the secondary sealing member being (160;260) activatable by rotation of the mandrel; and an anti-rotation assembly (120;220) to inhibit rotation of the secondary sealing member relative to the casing. a mandrel (105;205); a primary sealing member (150;255) disposed on the mandrel for forming a seal with the casing, the primary sealing member being operable by an increase in internal pressure in the fill up tool; characterised by: a selectively operable secondary sealing member for forming a secondary seal with the casing, the secondary sealing member being (160;260) activatable by rotation of the mandrel; and an anti-rotation assembly (120;220) to inhibit rotation of the secondary sealing member relative to the casing. a selectively operable secondary sealing member for forming a secondary seal with the casing, the secondary sealing member being (160;260) activatable by rotation of the mandrel; and an anti-rotation assembly (120;220) to inhibit rotation of the secondary sealing member relative to the casing.
A method, performed by a display apparatus, of performing a split-screen display in a terminal, the method comprising: when an event notification message is received while an application is being executed, determining whether the arrevent notification message is set by the user to be displayed on a notification bar; when the event notification is displayed on the notification bar: obtaining a view instruction for viewing the received event notification message, splitting a screen of the terminal into an original application area and a new application area based on the received view instruction, displaying an interface of the application that is being executed in the terminal on the original application area by reducing a size of content of the interface of the application that is being executed, and displaying an interface of an application related to the received event notification message on the new application area. when an event notification message is received while an application is being executed, determining whether the arrevent notification message is set by the user to be displayed on a notification bar; when the event notification is displayed on the notification bar: obtaining a view instruction for viewing the received event notification message, splitting a screen of the terminal into an original application area and a new application area based on the received view instruction, displaying an interface of the application that is being executed in the terminal on the original application area by reducing a size of content of the interface of the application that is being executed, and displaying an interface of an application related to the received event notification message on the new application area.
A polishing composition for polishing silicon wafer, the polishing composition comprising an abrasive, a water-soluble polymer and water, wherein the abrasive consists of silica grains, the average secondary particle diameter D P2 of the silica grains being 20 nm to 100 nm, measured on an aqueous dispersion of the silica grains by dynamic light scattering, and wherein the water-soluble polymer satisfies the following conditions: the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic. wherein the abrasive consists of silica grains, the average secondary particle diameter D P2 of the silica grains being 20 nm to 100 nm, measured on an aqueous dispersion of the silica grains by dynamic light scattering, and wherein the water-soluble polymer satisfies the following conditions: the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic. the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic.
A clamping device for an external fixation system, comprising: a clamping system, and a post component extending into the clamping system; the clamping system comprising an outer jaw (110, 110a); an inner jaw (108, 108a) having an inner surface facing the outer jaw (110, 110a), the outer and inner jaws together forming an opening for receiving a fixation element of the external fixation system; characterized in that the clamping device further comprises a trigger system that releases the outer jaw (110, 110a) and the inner jaw (108, 108a) from a cocked, open bar-receiving condition to a provisionally locked condition that prevents removal of a fixation element out from between the jaws, but allows a fixation element to slide and rotate relative to the jaws, wherein the trigger system comprises a release component pivotably attached to the inner jaw, and a biasing element that biases the release component toward the provisionally locked condition, wherein the release component slidingly engages the outer jaw to bias the outer jaw to the provisionally locked condition. a clamping system, and a post component extending into the clamping system; the clamping system comprising an outer jaw (110, 110a); an inner jaw (108, 108a) having an inner surface facing the outer jaw (110, 110a), the outer and inner jaws together forming an opening for receiving a fixation element of the external fixation system; characterized in that the clamping device further comprises a trigger system that releases the outer jaw (110, 110a) and the inner jaw (108, 108a) from a cocked, open bar-receiving condition to a provisionally locked condition that prevents removal of a fixation element out from between the jaws, but allows a fixation element to slide and rotate relative to the jaws, wherein the trigger system comprises a release component pivotably attached to the inner jaw, and a biasing element that biases the release component toward the provisionally locked condition, wherein the release component slidingly engages the outer jaw to bias the outer jaw to the provisionally locked condition.
Metering device for a coating system for the serial coating of workpieces with different colour shades, wherein by means of the metering device the current amount of applied coating material can be changed in a controlled manner during application, comprising a plurality of paint valves which are mounted or installed on or in the metering device (10, 20) or a storage container of the metering device and can be controlled by signals for the selection of the coating materials from paint lines (13, 13'), wherein the metering device (10, 20, 50) a) is or comprises a gear metering pump (50, 100), or b) is a piston-type metering means or comprises a piston-type metering means, the metering drive of which can be controlled in order to change the piston speed during application, wherein the piston-type metering means or a container arranged upstream thereof has an inlet (E1-E5) for each paint line, characterised in that the plurality of paint valves mounted on or installed in the metering device (10, 20, 50) or a storage container of the metering device are formed by automatically controlled needle valve units (FV63, FV83, FV103). a) is or comprises a gear metering pump (50, 100), or b) is a piston-type metering means or comprises a piston-type metering means, the metering drive of which can be controlled in order to change the piston speed during application, wherein the piston-type metering means or a container arranged upstream thereof has an inlet (E1-E5) for each paint line,
A guidance tool for intraoperative use during tissue, bone or joint manipulation, comprising: a body portion, including; a patient-specific mating surface that is preoperatively designed to mate with one or more first landmarks of a corresponding registration surface of the patient's anatomy, said mating surface for positioning said guidance tool on said registration surface of the patient's anatomy; and at least one guide mechanism adapted to guide at least one medical instrument at one or more position and trajectory relative to the one or more first landmarks of the patient's anatomy; characterised in that the guidance tool further comprises a verification tool that includes: a protruding part that removably engages the body portion; and a pointer extending from the protruding part; wherein the pointer is adapted to locate one or more preoperatively selected second landmarks on the patient's anatomy, to verify at least one of (i) the position of the guidance tool on the patient's anatomy and (ii) the position and trajectory of the at least one medical instrument when the at least one medical instrument is inserted into the at least one guide mechanism. a body portion, including; a patient-specific mating surface that is preoperatively designed to mate with one or more first landmarks of a corresponding registration surface of the patient's anatomy, said mating surface for positioning said guidance tool on said registration surface of the patient's anatomy; and at least one guide mechanism adapted to guide at least one medical instrument at one or more position and trajectory relative to the one or more first landmarks of the patient's anatomy; characterised in that the guidance tool further comprises a verification tool that includes: a protruding part that removably engages the body portion; and a pointer extending from the protruding part; a protruding part that removably engages the body portion; and a pointer extending from the protruding part; wherein the pointer is adapted to locate one or more preoperatively selected second landmarks on the patient's anatomy, to verify at least one of (i) the position of the guidance tool on the patient's anatomy and (ii) the position and trajectory of the at least one medical instrument when the at least one medical instrument is inserted into the at least one guide mechanism.
A pouch-shaped secondary battery comprising a laminate sheet for receiving an electrode assembly and an electrolytic solution, wherein the laminate sheet is configured to have a structure comprising an outer coating layer, a metal layer, and an inner adhesive layer, and a heat transfer member is provided in order to connect the electrode assembly to the metal layer of the laminate sheet, wherein the heat transfer member comprises a flat type main body and a protrusion extending perpendicularly from one surface of the flat type main body, the flat type main body is located between the inner adhesive layer of the laminate sheet and the outermost electrode of the electrode assembly, and the protrusion is configured to have a structure extending through the inner adhesive layer of the laminate sheet, the heat transfer member is configured to have a protruding structure extending perpendicularly from an outer surface of an outermost electrode of the electrode assembly, characterized in that: the protruding structure comprises a plurality of protrusions arranged at uniform intervals, a height of the protruding structure is 100% to 120% of a thickness of the inner adhesive layer of the laminate sheet, and the protruding structure has a height ranging from 20 μ m to 140 μ m. the protruding structure comprises a plurality of protrusions arranged at uniform intervals, a height of the protruding structure is 100% to 120% of a thickness of the inner adhesive layer of the laminate sheet, and the protruding structure has a height ranging from 20 μ m to 140 μ m.
A delivery device for a sheet-processing machine comprising at least one deposition station and a conveyor system, by means of which upstream processed sheets of printed material can be picked up in a transfer location, can be conveyed to a first deposition station via a first conveying section, where they can be deposited optionally to a first stack to be formed there or can be conveyed by the conveyor system beyond said stack and further conveyed downstream to a second deposition station comprising a second stacking space via a second conveying section, where they can be deposited by the conveyor system to a second stack (11, 12) to be formed, characterized in that a holding device which holds down the uppermost sheet of the stack during the transfer of a sheet to be conveyed against an entrainment and/or lifting, is provided with one or a plurality of holding means which are spaced apart from each other transversely to the transport direction and in holding position brought into contact with the uppermost stacking position and/or a sheet-guiding element is provided, which adjoins the deposition station and is variable in its vertical position with at least its upstream end by means of an actuating device (283, 284), via which a further sheet of printed material downstream of the first deposition station can be transported in a guided manner via the conveyor system.
A method for preparing anhydrous -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide as a maleate salt comprising the steps of: i) heating -N- {4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and maleic acid to 50-60°C in a water:n-propanol solution and maintaining the mixture at 50-60°C for a minimum of 15 min; ii) cooling said solution over at least one hour to 40°C and maintaining the cooled solution at 40°C for 12 hours; iii) further cooling the cooled solution to room temperature, 25°C, over a minimum of 4 hours and maintaining the further cooled solution at room temperature, 25°C, for at least 2 hours; iv) filtering the mixture obtained in step iii) to obtain crystalline -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate salt, wherein the crystalline -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate salt is -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate monohydrate; and v) drying the -N-{4-[3-chloro-4-(2-pyridinylmcthoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate monohydrate from step iv) under vacuum at a temperature greater than 30°C for 12 to 48 hours to obtain crystalline, anhydrous -N- {4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide maleate. i) heating -N- {4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and maleic acid to 50-60°C in a water:n-propanol solution and maintaining the mixture at 50-60°C for a minimum of 15 min; ii) cooling said solution over at least one hour to 40°C and maintaining the cooled solution at 40°C for 12 hours; iii) further cooling the cooled solution to room temperature, 25°C, over a minimum of 4 hours and maintaining the further cooled solution at room temperature, 25°C, for at least 2 hours; iv) filtering the mixture obtained in step iii) to obtain crystalline -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate salt, wherein the crystalline -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate salt is -N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate monohydrate; and v) drying the -N-{4-[3-chloro-4-(2-pyridinylmcthoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate monohydrate from step iv) under vacuum at a temperature greater than 30°C for 12 to 48 hours to obtain crystalline, anhydrous -N- {4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide maleate.
A pedestal/stand for raised floors, which can be applied on a plurality of heads of supports for raised floors, comprising at least one beam and, said beam being of the contoured type and comprising at least one zone for interlocking mechanical association with said heads of supports, said beam being constituted by two tubular bodies (15a, 15b) which are substantially quadrangular in cross-section, said tubular bodies (15a, 15b) being symmetrical with respect to said zone for interlocking mechanical association with said heads of supports, said tubular bodies (15a, 15b) being joined by a bridge which is adjacent to said zone for interlocking mechanical association with said heads of supports, characterized in that each one of said tubular bodies (15a, 15b) has two longitudinal secondary slits (18a', 18a", 18b', 18b"), each one of said secondary slits (18a', 18a", 18b', 18b") being arranged on the outer surface of one of the walls of the respective one of said tubular bodies (15a, 15b) which are parallel to said bridge.
Method for producing an electrical connection by means of plastic deformation between at least one contact face of a first contact element, for example, a wire or a strand, and the contact face of a second contact element, wherein the first contact element and the second contact element comprise materials with the same redox potential, characterised in that a chemically reducing substance is applied to at least one of the contact faces (3, 4).
A Measuring device, for determining a pressure map during application of pressure to at least one measurement layer between a first pressure body and a second pressure body, with: - at least one transmitter located on one peripheral edge of the measurement layer for emission of signals in the form of electromagnetic waves along a first signal route which runs through the measurement layer and at least one other signal route which runs through the measurement layer, - at least one receiver (8, 8') located on the peripheral edge for the reception of the signals of the first signal route and other signal route(s), which signals are sent by the transmitter through the measurement layer, - an evaluation unit for determining localized pressure values of the pressure map along the signal routes of the signals received by the receiver (8, 8'), wherein for determining the pressure map a reconstruction of the video signals of a volume is conducted. - at least one transmitter located on one peripheral edge of the measurement layer for emission of signals in the form of electromagnetic waves along a first signal route which runs through the measurement layer and at least one other signal route which runs through the measurement layer, - at least one receiver (8, 8') located on the peripheral edge for the reception of the signals of the first signal route and other signal route(s), which signals are sent by the transmitter through the measurement layer, - an evaluation unit for determining localized pressure values of the pressure map along the signal routes of the signals received by the receiver (8, 8'), wherein for determining the pressure map a reconstruction of the video signals of a volume is conducted.
Diversion device for a transport device for transporting products, where said diversion device comprises a first element mounted to be rotatable about a first axis of rotation and a second element mounted to be rotatable about a second axis of rotation, where said axes of rotation form an angle with one another and said first and said second element overlap in a region so that said first and said second element enclose a diversion region, where a product supplied to said diversion region can be diverted in said diversion region by rotating said first and said second element and can exit said diversion device after having passed said diversion region due to mass inertia.
A processor for controlling for a planned radiographic exposure the spatial position of a portable digital direct x-ray detector in a medical imaging system comprising multiple radiographic exposure stands comprising the following means: ° means for creating a threedimensional spatial model of the medical imaging system; ° means for determining within said model the spatial position of said detector based on input received from three gravity sensors installed within said detector; ° means for determining within said model a three-dimensional volume space for each radiographic exposure stand comprised in said medical imaging system; ° means for checking whether for the planned radiographic exposure the spatial position of said detector to be used in said exposure fits within the three-dimensional volume space of the radiographic exposure stand to be used in said exposure. ° means for creating a threedimensional spatial model of the medical imaging system; ° means for determining within said model the spatial position of said detector based on input received from three gravity sensors installed within said detector; ° means for determining within said model a three-dimensional volume space for each radiographic exposure stand comprised in said medical imaging system; ° means for checking whether for the planned radiographic exposure the spatial position of said detector to be used in said exposure fits within the three-dimensional volume space of the radiographic exposure stand to be used in said exposure.