mhurhangee/ep-ind-claims huggingface dataset:
A method of monitoring the efficacy of an immunotherapy in a mammalian subject having a cancer that expresses the 5T4 antigen, wherein the subject has been administered an immunotherapy, wherein the immunotherapy comprises a modified vaccinia Ankara viral vector containing a polynucleotide encoding 5T4, wherein the viral vector is capable of transducing cells in the mammalian subject to cause the cells to express 5T4; the method comprising: (a) measuring, from a biological sample isolated from the subject, an immune response of the subject to 5T4 and comparing the immune response of the subject to 5T4 to an average or median measurement of immune response to 5T4 calculated from a plurality of mammalian subjects to whom the immunotherapy has been administered; (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to an average or median measurement of immune response to the viral vector calculated from a plurality of mammalian subjects to whom the immunotherapy has been administered; (c) determining efficacy based on the comparisons of (a) and (b), wherein an elevated immune response to 5T4 and a reduced immune response to the viral vector are indicative of an effective immunotherapy wherein a measurement for the mammalian subject above the reference measurement is scored as elevated, and a measurement below the reference measurement is scored as reduced. (a) measuring, from a biological sample isolated from the subject, an immune response of the subject to 5T4 and comparing the immune response of the subject to 5T4 to an average or median measurement of immune response to 5T4 calculated from a plurality of mammalian subjects to whom the immunotherapy has been administered; (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to an average or median measurement of immune response to the viral vector calculated from a plurality of mammalian subjects to whom the immunotherapy has been administered; (c) determining efficacy based on the comparisons of (a) and (b), wherein an elevated immune response to 5T4 and a reduced immune response to the viral vector are indicative of an effective immunotherapy wherein a measurement for the mammalian subject above the reference measurement is scored as elevated, and a measurement below the reference measurement is scored as reduced.
A method for determining a robust synthetic signal indicative of a bioelectric activity of an individual wherein: - at least two measurement signals, which are respectively representative of two physiological electrical signals of an individual, are continuously acquired, by means of at least two electrodes placed in contact, or in proximity, with an individual, - at least two time series of confidence indices, which are respectively associated with said measurement signals, are continuously built, from the measurement signals and by means of a processing unit, - a synthetic signal is continuously determined, from said measurement signals and said time series of confidence indices, by means of said processing unit, characterised in that, 1) in order to continuously determine the synthetic signal, each of said measurement signals is continuously analysed to identify predefined patterns of bioelectric activity and a list of patterns, which are identified by analysing said measurement signal, is associated with each of said measurement signals, each identified pattern being associated with a time instant or a time window of recording in the associated measurement signal, and 2) for each time instant or time window of recording in the associated measurement signal, and for each pattern of the list of identified patterns, a probability that an event, which is associated with the pattern, takes place is determined. - at least two measurement signals, which are respectively representative of two physiological electrical signals of an individual, are continuously acquired, by means of at least two electrodes placed in contact, or in proximity, with an individual, - at least two time series of confidence indices, which are respectively associated with said measurement signals, are continuously built, from the measurement signals and by means of a processing unit, - a synthetic signal is continuously determined, from said measurement signals and said time series of confidence indices, by means of said processing unit, 1) in order to continuously determine the synthetic signal, each of said measurement signals is continuously analysed to identify predefined patterns of bioelectric activity and a list of patterns, which are identified by analysing said measurement signal, is associated with each of said measurement signals, each identified pattern being associated with a time instant or a time window of recording in the associated measurement signal, and 2) for each time instant or time window of recording in the associated measurement signal, and for each pattern of the list of identified patterns, a probability that an event, which is associated with the pattern, takes place is determined.
A razor cartridge comprising a housing having a base which is connectable to a handle, two or more blades, whose tips are aligned in a cutting plane to cut in a cutting direction, and a moisturizing block disposed before and/or after the blades in the cutting direction, the moisturizing block having a skin-contacting surface, wherein: (a) the moisturizing block comprises at least 50% lipophilic materials by weight of the moisturizing block; (b) the skin-contacting surface slopes away from the blades towards the base. (a) the moisturizing block comprises at least 50% lipophilic materials by weight of the moisturizing block; (b) the skin-contacting surface slopes away from the blades towards the base.
A heating unit with a resistive element formed as a conducting pattern, which resistive element is bound to a substrate, such as a base plate, on which the resistive element is extended, and which resistive element is arranged to be placed under the influence of an electrical voltage, c h a r a c t e r i s e d i n that the resistive element is placed on a free surface of the substrate and is directly exposed to the surroundings and where the resistive element and the substrate have the same or essentially the same coefficients of thermal expansion, in that the resistive element has been bound to the substrate by sintering and in that the coefficients of thermal expansion of the resistive element and of the base plate differ from each other by less than 10% and wherein the resistive element consists of a Ti-Al-C material or of this material in alloy with Nb, and in that the base plate consists of Al 2 O 3.
A method of storing and managing measurements taken in an oilfield or wellbore, the method comprising: receiving the measurements as raw data (210; 215), wherein the raw data is acquired by an oilfield measurement or wellbore monitoring device, the raw data including traces at multiple X and Y coordinate values, converting the raw data to image rasters, wherein the converting does not comprise down-sampling the raw data, and wherein the converting includes: for each X coordinate and each Y coordinate, stacking multiple planar trace image rasters along the given X or Y coordinate to produce an image raster corresponding to the X or Y coordinate; assigning first unique identifiers, UIDs, to the raw data, wherein the first UIDs are stored separately from the raw data in a relational database, and wherein the raw data is queried using the first UIDs without reading the raw data; assigning second UIDs to at least each of the X and the Y coordinate image rasters; and storing at least the X and the Y coordinate image rasters along with the assigned second UIDs. receiving the measurements as raw data (210; 215), wherein the raw data is acquired by an oilfield measurement or wellbore monitoring device, the raw data including traces at multiple X and Y coordinate values, converting the raw data to image rasters, wherein the converting does not comprise down-sampling the raw data, and wherein the converting includes: for each X coordinate and each Y coordinate, stacking multiple planar trace image rasters along the given X or Y coordinate to produce an image raster corresponding to the X or Y coordinate; assigning first unique identifiers, UIDs, to the raw data, wherein the first UIDs are stored separately from the raw data in a relational database, and wherein the raw data is queried using the first UIDs without reading the raw data; assigning second UIDs to at least each of the X and the Y coordinate image rasters; and storing at least the X and the Y coordinate image rasters along with the assigned second UIDs.
Fastening device for furniture shelves or wall shelves comprising: - an L-shaped body member for supporting a furniture shelf or wall shelf, said body member being connectable to an inner surface of a piece of furniture or to a wall; - a fixing element associable with said body member, said fixing element being movable between a raised position, wherein placing the shelf on said body member or removing the shelf from said body member is allowed, and a lowered position, wherein said fixing element is arranged on the upper surface of said shelf, wherein said fixing element is rotatably associated with said body member to move between said raised position and said lowered position, a locking element comprising locking means being slidably associated with said fixing element and movable between an unlocking position, wherein said locking means allow the rotation of said fixing element, and a locking position, wherein said locking means prevent the rotation of the fixing element when said fixing element is in the lowered position. - an L-shaped body member for supporting a furniture shelf or wall shelf, said body member being connectable to an inner surface of a piece of furniture or to a wall; - a fixing element associable with said body member, said fixing element being movable between a raised position, wherein placing the shelf on said body member or removing the shelf from said body member is allowed, and a lowered position, wherein said fixing element is arranged on the upper surface of said shelf, wherein
A hand-held vapour generating device (100/200) for producing a vapour for inhalation by a user, this device comprising: an oven arranged to receive a vapour generating substrate; an inlet; an outlet; an airflow passageway for providing a fluid connection between the inlet and the outlet via the oven and through which generated vapour can flow to the outlet; a device controller; a humidity sensor for generating a measurement of a vapor produced by said substrate, wherein the device controller is arranged to control the operation of the device based on measurement data from the humidity sensor; and a gas sensor for measuring adverse/undesirable components in the produced vapor, such that when the device controller determines that a substrate is genuine, based on the measurement data from the humidity sensor, said gas sensor takes measurement of the generated vapour. an oven arranged to receive a vapour generating substrate; an inlet; an outlet; an airflow passageway for providing a fluid connection between the inlet and the outlet via the oven and through which generated vapour can flow to the outlet; a device controller; a humidity sensor for generating a measurement of a vapor produced by said substrate, wherein the device controller is arranged to control the operation of the device based on measurement data from the humidity sensor; and a gas sensor for measuring adverse/undesirable components in the produced vapor, such that when the device controller determines that a substrate is genuine, based on the measurement data from the humidity sensor, said gas sensor takes measurement of the generated vapour.
An electromagnetic actuator device comprising armature means which, as a reaction to an energization of stationary coil means, are movable in an actuator housing along an axial direction relative to stationary core means, and which are gripped by axially elongated plunger means guided in a core passage of the core means in such a manner that a movement of the armature means in the direction to the core means can entrain the plunger means, an end section of the plunger means, axially opposite the armature means, being configured to interact with or to realize a control partner, in particular a valve slide, wherein the plunger means comprise an elongated rod section and a disk-shaped end section which has a widened diameter and which sits on the rod section in one piece on the end side in the direction to the armature means, wherein the axial extension of the end section determines a minimum distance between the armature means and the core means, in particular in the form of a magnetic anti-adhesive disk, in an abutment state of the armature means on an end surface and/or front surface of the core means facing the armature means. armature means which, as a reaction to an energization of stationary coil means, are movable in an actuator housing along an axial direction relative to stationary core means, and which are gripped by axially elongated plunger means guided in a core passage of the core means in such a manner that a movement of the armature means in the direction to the core means can entrain the plunger means, an end section of the plunger means, axially opposite the armature means, being configured to interact with or to realize a control partner, in particular a valve slide, wherein the plunger means comprise an elongated rod section and a disk-shaped end section which has a widened diameter and which sits on the rod section in one piece on the end side in the direction to the armature means, wherein the axial extension of the end section determines a minimum distance between the armature means and the core means, in particular in the form of a magnetic anti-adhesive disk, in an abutment state of the armature means on an end surface and/or front surface of the core means facing the armature means.
A method of injection molding an article, the method comprising: using an injection molding machine (100, 300) that includes a melt source of molten material, a mold defining a mold cavity, a gate (106, 206, 306) in fluid communication with the melt source and the mold cavity, wherein the gate (106, 206, 306) defines an orifice area, and a mold core (110, 310) movable relative to the gate (106, 206, 306); directing a first shot of molten material into the mold cavity through a first portion of the orifice area of the gate (106, 206, 306) while simultaneously occluding a second portion of the orifice area of the gate (106, 206, 306) with the mold core (110, 310); solidifying the first shot of molten material to form a first part (108, 320) of the article; directing the mold core (110, 310) away from the gate (106, 206, 306) after the first part (108, 320) has been formed; directing a second shot of molten material into the mold cavity through the second portion of the orifice area of the gate (106, 206, 306) while simultaneously occluding the first portion of the orifice area of the gate (106, 206, 306) with the first part (108, 320) of the article; and solidifying the second shot of molten material to form a second part of the article; preferably wherein the molten material is a thermoplastic polymer, a thermosetting polymer, or an elastomer. using an injection molding machine (100, 300) that includes a melt source of molten material, a mold defining a mold cavity, a gate (106, 206, 306) in fluid communication with the melt source and the mold cavity, wherein the gate (106, 206, 306) defines an orifice area, and a mold core (110, 310) movable relative to the gate (106, 206, 306); a melt source of molten material, a mold defining a mold cavity, a gate (106, 206, 306) in fluid communication with the melt source and the mold cavity, wherein the gate (106, 206, 306) defines an orifice area, and a mold core (110, 310) movable relative to the gate (106, 206, 306); directing a first shot of molten material into the mold cavity through a first portion of the orifice area of the gate (106, 206, 306) while simultaneously occluding a second portion of the orifice area of the gate (106, 206, 306) with the mold core (110, 310); solidifying the first shot of molten material to form a first part (108, 320) of the article; directing the mold core (110, 310) away from the gate (106, 206, 306) after the first part (108, 320) has been formed; directing a second shot of molten material into the mold cavity through the second portion of the orifice area of the gate (106, 206, 306) while simultaneously occluding the first portion of the orifice area of the gate (106, 206, 306) with the first part (108, 320) of the article; and solidifying the second shot of molten material to form a second part of the article; preferably wherein the molten material is a thermoplastic polymer, a thermosetting polymer, or an elastomer.
A power toothbrush, comprising: a driving assembly, including a battery and a DC motor, the DC motor having a rotating drive shaft extending therefrom, the drive shaft having a free end rotationally mounted in a support member, the drive shaft having an eccentric portion located proximally from the free end thereof; a spring assembly extending from the eccentric portion, the spring assembly including a spring member comprising two spring member portions (60, 62) having a pre-load such that the two spring member portions are always in compression; a brushhead shaft member, wherein the brushhead shaft member has a yoke member secured thereto and extending away therefrom, the yoke member also being secured to the spring member, wherein in operation, an oscillating action of the brushhead shaft is produced as the eccentric portion of the drive shaft rotates; and a brushhead assembly with bristles mounted on the brushhead shaft for cleaning a user's teeth. a driving assembly, including a battery and a DC motor, the DC motor having a rotating drive shaft extending therefrom, the drive shaft having a free end rotationally mounted in a support member, the drive shaft having an eccentric portion located proximally from the free end thereof; a spring assembly extending from the eccentric portion, the spring assembly including a spring member comprising two spring member portions (60, 62) having a pre-load such that the two spring member portions are always in compression; a brushhead shaft member, wherein the brushhead shaft member has a yoke member secured thereto and extending away therefrom, the yoke member also being secured to the spring member, wherein in operation, an oscillating action of the brushhead shaft is produced as the eccentric portion of the drive shaft rotates; and a brushhead assembly with bristles mounted on the brushhead shaft for cleaning a user's teeth.
Method for managing by a remote server an implementation on a vehicle of a first and a second service, the method being implemented by the remote server and comprising the steps of: - receiving a summary message comprising information on a state of a first functional parameter of the vehicle and information on a state of a second functional parameter of the vehicle, a summary message being received at a predetermined frequency; the process being characterized in that: - for each reception of a summary message, identification of a possibility of implementation on the vehicle of the first service and the second service, from the summary message and a predetermined reference of correspondence between services and vehicle states; - upon identification of the possibility of implementing the first service, transmission to the vehicle of a request to execute the first service over a first implementation window, the first implementation window corresponding to a first multiple of the period corresponding to the predetermined frequency; - upon identification of the possibility of implementing the second service, transmission to the vehicle of a request for execution of the second service over a second implementation window, the second implementation window corresponding to a second multiple of the period corresponding to the predetermined frequency. - receiving a summary message comprising information on a state of a first functional parameter of the vehicle and information on a state of a second functional parameter of the vehicle, a summary message being received at a predetermined frequency; the process being characterized in that: - for each reception of a summary message, identification of a possibility of implementation on the vehicle of the first service and the second service, from the summary message and a predetermined reference of correspondence between services and vehicle states; - upon identification of the possibility of implementing the first service, transmission to the vehicle of a request to execute the first service over a first implementation window, the first implementation window corresponding to a first multiple of the period corresponding to the predetermined frequency; - upon identification of the possibility of implementing the second service, transmission to the vehicle of a request for execution of the second service over a second implementation window, the second implementation window corresponding to a second multiple of the period corresponding to the predetermined frequency.
A decorated thermoplastic film comprising: (i) a substrate having a first surface and a second surface located opposite the first surface, the substrate having a graphic saturated into the first surface and the first surface comprising a film layer comprising poly vinyl fluoride or poly vinylidine fluoride (PVDF); and (ii) a thermoplastic composition in contact with the second surface of the substrate, wherein the thermoplastic composition does not contact the first surface of the substrate. (i) a substrate having a first surface and a second surface located opposite the first surface, the substrate having a graphic saturated into the first surface and the first surface comprising a film layer comprising poly vinyl fluoride or poly vinylidine fluoride (PVDF); and (ii) a thermoplastic composition in contact with the second surface of the substrate, wherein the thermoplastic composition does not contact the first surface of the substrate.
A liquid crystalline polyester fiber exhibiting a running tension fluctuation range of 5 cN or less and an oil adhesion rate of 3.0 wt% or less, which is obtainable by a method which comprises subjecting a yarn prepared by melt spinning a liquid crystalline polyester to a solid-phase polymerization after applying inorganic particles and a phosphate-based compound to said yarn, wherein the running tension fluctuation range is determined by method A as described herein and the oil adhesion rate is determined by method D using sodium dodecyl benzene sulfonate as described herein.
Network switch, comprising: plural communication ports (103, 105), each port having a first electrical output terminal and a second electrical output terminal for providing an electrical output signal between the first electrical output terminal and the second electrical output terminal, wherein the network switch is adapted to electrically switch off the electrical output signal of at least one communication port of the plural communication ports, characterized in that the network switch is adapted such that the first electrical output terminal of the at least one communication port has a same electrical potential as the second electrical output terminal of the at least one communication port, when the electrical output signal of the at least one communication port is switched off. plural communication ports (103, 105), each port having a first electrical output terminal and a second electrical output terminal for providing an electrical output signal between the first electrical output terminal and the second electrical output terminal,