A hinge of a door or a window, comprising: - a pair of bodies, each formed by a tubular portion comprising a through hole for housing a hinge pin, and a wing for fixing to a respective profile of a fixed or mobile frame of a door or a window, the fixing wing comprising at least one hole which is at a right angle to the through hole; - a hinge pin inserted coaxially in the through holes, thus allowing the bodies to rotate relative to each other; - means for fixing each body to the profile, the hinge comprising, in combination: - a fixing screw for fixing the wing of the body to the profile, comprising a head and a shank, the shank further comprising proceeding longitudinally away from the head: - a first portion having a first diameter and proximal to the head; - a second, intermediate portion having a second diameter configured to centre in a hole made in the profile having an equal diameter (D2'); - a third threaded portion having a third diameter and distal from the head, wherein the diameters (D1, D2, D3) of the first, second and third portions (9, 10, 11) are decreasing proceeding away from the head; - the hole made in the wing of the body being configured to house the first portion of the shank of the screw and having a portion with a diameter (D1') equal to the diameter of the first portion of the shank, the hinge further having: - longitudinal contact means for the screw, which are insertable in the profile for coupling with the third portion of the screw, comprising a plate, insertable in the profile and provided with a threaded hole configured for engaging with the third portion of the screw and to lock the wing relative to the profile. - a pair of bodies, each formed by a tubular portion comprising a through hole for housing a hinge pin, and a wing for fixing to a respective profile of a fixed or mobile frame of a door or a window, the fixing wing comprising at least one hole which is at a right angle to the through hole; - a hinge pin inserted coaxially in the through holes, thus allowing the bodies to rotate relative to each other; - means for fixing each body to the profile, the hinge comprising, in combination: - a fixing screw for fixing the wing of the body to the profile, comprising a head and a shank, the shank further comprising proceeding longitudinally away from the head: - a first portion having a first diameter and proximal to the head; - a second, intermediate portion having a second diameter configured to centre in a hole made in the profile having an equal diameter (D2'); - a third threaded portion having a third diameter and distal from the head, wherein the diameters (D1, D2, D3) of the first, second and third portions (9, 10, 11) are decreasing proceeding away from the head; - a fixing screw for fixing the wing of the body to the profile, comprising a head and a shank, the shank further comprising proceeding longitudinally away from the head: - a first portion having a first diameter and proximal to the head; - a second, intermediate portion having a second diameter configured to centre in a hole made in the profile having an equal diameter (D2'); - a third threaded portion having a third diameter and distal from the head, wherein the diameters (D1, D2, D3) of the first, second and third portions (9, 10, 11) are decreasing proceeding away from the head; - the hole made in the wing of the body being configured to house the first portion of the shank of the screw and having a portion with a diameter (D1') equal to the diameter of the first portion of the shank, the hinge further having: - longitudinal contact means for the screw, which are insertable in the profile for coupling with the third portion of the screw, comprising a plate, insertable in the profile and provided with a threaded hole configured for engaging with the third portion of the screw and to lock the wing relative to the profile. - longitudinal contact means for the screw, which are insertable in the profile for coupling with the third portion of the screw, comprising a plate, insertable in the profile and provided with a threaded hole configured for engaging with the third portion of the screw and to lock the wing relative to the profile.