mhurhangee/ep-ind-claims huggingface dataset:
A variant carboxylic acid reductase polypeptide comprising an amino acid sequence having at least 90% sequence identity to the wild-type CAR polypeptide of SEQ ID NO: 7, wherein said variant CAR polypeptide is genetically engineered to have at least one mutation at an amino acid position selected from the group consisting of S3R, D18R, D18L, D18T, D18P, E20V, E20S, E20R, S22R, S22N, S22G, L80R, R87G, R87E, V191 S, F288R, F288S, F288G, Q473L, Q473W, Q473Y, Q473I, Q473H, A535S, D750A, R827C, R827A, I870L, R873S, V926A, V926E, S927K, S927G, M930K, M930R and L1128W, wherein expression of said variant CAR polypeptide in a recombinant host cell results in a higher titer of fatty alcohol compositions compared to a recombinant host cell expressing the wild type CAR polypeptide of SEQ ID NO:7.
A method of manufacturing a protective coating suitable for an e-paper structure and further suitable for receiving airborne charges from a non-contact, external image-writing module and for facilitating the passage of those charges to a charge-responsive layer of the e-paper structure that is imageable by the charges, the method characterised by comprising: forming a first layer in which conductive particles are dispersed within a substantially conductive-resistant matrix medium, on a first side of a substrate; applying a field to cause the conductive particles to align in generally parallel, spaced apart elongate patterns that are generally perpendicular to a plane in which the first layer extends; and curing, at ambient temperatures and without applied pressure, the first layer via radiation energy while maintaining the applied field to produce the protective coating with at least a non-adhesive outer surface. forming a first layer in which conductive particles are dispersed within a substantially conductive-resistant matrix medium, on a first side of a substrate; applying a field to cause the conductive particles to align in generally parallel, spaced apart elongate patterns that are generally perpendicular to a plane in which the first layer extends; and curing, at ambient temperatures and without applied pressure, the first layer via radiation energy while maintaining the applied field to produce the protective coating with at least a non-adhesive outer surface.
A method for identifying PD1+ immune cells in a sample, comprising analyzing the methylation status of at least one CpG position in the mammalian gene region for Programmed cell death 1 (PDCD1), wherein said at least one CpG position is selected from a CpG selected from the CpG positions 27, 47, 82, 136, 194, 197, 249, 285, 290, 303, 336, 354, and 369 in the amplicon 1876 according to SEQ ID No. 2, CpG positions 31, 60, 75, 86, 114, 138, 142, 171, 184, 210, 217, and 241 in the amplicon 1877 according to SEQ ID No. 3, CpG positions 35, 56, 74, 104, 118, 130, 150, 182, 196, and 212 in the amplicon 1878 according to SEQ ID No. 4, and is preferably selected from CpG positions 60, 75, 86, 114, 138, 142, 171, 184, 210, 217, and 241 in a fragment of the amplicon 1877 according to SEQ ID No. 3, and wherein a demethylation or lack of methylation of the CpG positions in said gene region to at least 70% is indicative for a PD1+ immune cell, when compared to a non-PD1+ cell.
A knob retention system, comprising: a nut which includes a base having a cylindrical shape including two opposing nut end faces (23a, 23b), a threaded bore aligned with a base central axis, a wall extending transversely from a first one of said nut end faces, said wall defining an inner surface which comprises a circular arc coaxial with said central axis, said wall extending at least partially around a circumference of said base to define a capture space; and an insert rotatably retained within said capture space by said wall includes a body having a cylindrical shape, a retention barb disposed on an outer cylindrical surface of said insert which is configured for engaging an interlocking formed on an interior bore of a user control knob, and a D-shaped bore extending along an insert central axis. a nut which includes a base having a cylindrical shape including two opposing nut end faces (23a, 23b), a threaded bore aligned with a base central axis, a wall extending transversely from a first one of said nut end faces, said wall defining an inner surface which comprises a circular arc coaxial with said central axis, said wall extending at least partially around a circumference of said base to define a capture space; and an insert rotatably retained within said capture space by said wall includes a body having a cylindrical shape, a retention barb disposed on an outer cylindrical surface of said insert which is configured for engaging an interlocking formed on an interior bore of a user control knob, and a D-shaped bore extending along an insert central axis.
A bogie for a low floor articulated rail vehicle, comprising: a frame; and a suspension traction device comprising a swing bolster mechanism, a traction rod mechanism, a primary spring mechanism and a secondary spring mechanism; wherein the secondary spring mechanism is arranged between the swing bolster mechanism and the frame of the bogie, wherein two groups of the swing bolster mechanisms and two sets of the traction rod mechanisms are provided, wherein two groups of swing bolster mechanisms are provided respectively in the middle of two groups of wheel-sets, and wherein each group of the swing bolster mechanism is connected to the frame via one set of traction rod mechanism, and each group of the swing bolster mechanism is connectable to a vehicle body by a rotary mechanism; characterized in that, a lifting device is provided between each group of the swing bolster mechanism and an end beam of the frame, said lifting device having at least one lifting rod, a top end of the lifting rod is connected to the swing bolster mechanism, a lifting opening is provided for the lifting rod on the frame, a bayonet having a diameter greater than the diameter of the lifting opening is provided at a bottom of the lifting rod and extends below the lifting opening, the frame has an upward-concaving portion at the lifting opening, the lifting opening is provided on a top wall of an upward-concaving portion, and the bayonet is provided inside the upward-concaving portion. a frame; and a suspension traction device comprising a swing bolster mechanism, a traction rod mechanism, a primary spring mechanism and a secondary spring mechanism; wherein the secondary spring mechanism is arranged between the swing bolster mechanism and the frame of the bogie, wherein two groups of the swing bolster mechanisms and two sets of the traction rod mechanisms are provided, wherein two groups of swing bolster mechanisms are provided respectively in the middle of two groups of wheel-sets, and wherein each group of the swing bolster mechanism is connected to the frame via one set of traction rod mechanism, and each group of the swing bolster mechanism is connectable to a vehicle body by a rotary mechanism; characterized in that, a lifting device is provided between each group of the swing bolster mechanism and an end beam of the frame, said lifting device having at least one lifting rod, a top end of the lifting rod is connected to the swing bolster mechanism, a lifting opening is provided for the lifting rod on the frame, a bayonet having a diameter greater than the diameter of the lifting opening is provided at a bottom of the lifting rod and extends below the lifting opening, the frame has an upward-concaving portion at the lifting opening, the lifting opening is provided on a top wall of an upward-concaving portion, and the bayonet is provided inside the upward-concaving portion.
A heterodimeric protein comprising a first IgG CH3-containing polypeptide and a second IgG CH3-containing polypeptide that meet together to form an interface engineered to promote heterodimer formation, wherein said first IgG CH3-containing polypeptide comprises a replacement of the amino acid at position 392 with a negative-charged amino acid and said second IgG CH3-containing polypeptide comprises a replacement of Asp399, Glu356, Asp356, or Glu357 with a positive-charged amino acid.
A system for renal replacement therapy comprising a blood treatment unit arranged to be connected to a blood circuit for extracorporeal circulation of blood comprising an arterial line and a venous line, wherein the blood treatment unit comprises a blood compartment and a fluid compartment separated by a semipermeable membrane, the system further comprises: - a blood pump arranged to create a blood flow rate Q B in the arterial line; - a pre-dilution line arranged for infusion of substitution fluid upstream the treatment unit; - a post-dilution line arranged for infusion of substitution fluid downstream the treatment unit; - flow control means arranged to regulate a pre-dilution flow rate Q pre of substitution fluid in the pre-dilution line and a post-dilution flow rate Q post of substitution fluid in the post-dilution line; - a control unit configured to control the system according to control instructions characterized in that the control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane based on a predetermined criterion for the determined system parameter value, and activate an automatic anti-fouling measure comprising a temporary increase of the pre-dilution flow rate Q pre and a temporary decrease of the post-dilution flow rate Q post from their present flow rates, respectively, during at least one time period Δt1, in order to create a flushing of the blood treatment unit, wherein the temporary increase comprises an increase of the pre-dilution flow rate Q pre to more than 100% of a value the post-dilution flow rate Q post had before the anti-fouling measure was activated. - a blood pump arranged to create a blood flow rate Q B in the arterial line; - a pre-dilution line arranged for infusion of substitution fluid upstream the treatment unit; - a post-dilution line arranged for infusion of substitution fluid downstream the treatment unit; - flow control means arranged to regulate a pre-dilution flow rate Q pre of substitution fluid in the pre-dilution line and a post-dilution flow rate Q post of substitution fluid in the post-dilution line; - a control unit configured to control the system according to control instructions characterized in that the control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane based on a predetermined criterion for the determined system parameter value, and activate an automatic anti-fouling measure comprising a temporary increase of the pre-dilution flow rate Q pre and a temporary decrease of the post-dilution flow rate Q post from their present flow rates, respectively, during at least one time period Δt1, in order to create a flushing of the blood treatment unit, wherein the temporary increase comprises an increase of the pre-dilution flow rate Q pre to more than 100% of a value the post-dilution flow rate Q post had before the anti-fouling measure was activated.
Method for forming a seal or cover on an opening of a vehicle body, in which an extruded strand made of an elastomer material is adhesively bonded to a support surface of the body receiving the strand, and, before the adhesive bonding, the support surface or/and a surface to be adhesively bonded of the strand is automatically supplied with adhesive material, characterized in that the supply of adhesive material is controlled in accordance with a requirement for the amount of adhesive material that changes in the longitudinal direction of the support surface and is related to the strand length, or/and in accordance with an arrangement of the surface to be adhesively bonded of the strand on the strand that changes in the longitudinal direction of the support surface, the control of the amount supplied taking place on the basis of signals of a sensor sensing the support surface or/and a stored relationship between the requirement for the amount supplied and the position on the path along the support surface.
A Chinese hamster ovary cell stably transfected with a vector, wherein the vector comprises: (i) an expression cassette, where the expression cassette comprises a first polynucleotide sequence encoding a first polypeptide of interest operably linked to a first expression promoter capable of effecting expression of the first polypeptide in a mammalian cell; and (ii) a polynucleotide sequence encoding a selectable marker operably linked to a dESV40 promoter, in which the dESV40 promoter consists of SEQ ID NO:1. (i) an expression cassette, where the expression cassette comprises a first polynucleotide sequence encoding a first polypeptide of interest operably linked to a first expression promoter capable of effecting expression of the first polypeptide in a mammalian cell; and (ii) a polynucleotide sequence encoding a selectable marker operably linked to a dESV40 promoter, in which the dESV40 promoter consists of SEQ ID NO:1.
A method of making an article of footwear with a printed structure, the method comprising: providing an upper of the article of footwear; providing a printer, the printer comprising a print head and a printable material; printing the printable material onto the upper to form an extended portion of the printed structure that is attached to the upper; and printing the printable material to form a fastener receiving portion of the printed structure that extends from the extended portion, wherein the fastener receiving portion includes an aperture for receiving a fastener, wherein the print head is moved in a distal direction with respect to the upper to form the fastener receiving portion so that at least a portion of the fastener receiving portion is spaced apart from the upper. providing an upper of the article of footwear; providing a printer, the printer comprising a print head and a printable material; printing the printable material onto the upper to form an extended portion of the printed structure that is attached to the upper; and printing the printable material to form a fastener receiving portion of the printed structure that extends from the extended portion, wherein the fastener receiving portion includes an aperture for receiving a fastener, wherein the print head is moved in a distal direction with respect to the upper to form the fastener receiving portion so that at least a portion of the fastener receiving portion is spaced apart from the upper.
A composition comprising medium chain triglycerides for use in a method of preventing and/or treating degenerative mitral valve disease (DMVD) in a companion animal, wherein the medium chain triglyceride is a lipid in which three fatty acids are bound by ester linkages to a glycerol backbone, and at least two of the fatty acids are each between six and twelve carbons in length.
A method of processing a multi-view video stream, comprising the steps of: receiving the multi-view video stream including a random access picture of a base view and at least one random access picture of a non-base view, each random access picture including a random access slice, the random access slice indicating a slice referring only to slices existing at a same time in a different view; receiving identification information indicating that the received multi-view video stream is a stereo video bitstream; obtaining flag information based on the identification information, the flag information indicating whether the random access picture of a base view is used for inter-view prediction of the random access picture of a non-base view; determining initialization information of a reference picture list of the random access picture of the non-base view based on the flag information; initializing the reference picture list of the random access picture of the non-base view using the initialization information; determining a prediction value of a macroblock in the random access picture of the non-base view based on the initialized reference picture list; and decoding the macroblock using the prediction value of the macroblock, wherein the base view indicates an independently decoded view without referring to a different view, and the non-base view indicates a view except the base view. receiving the multi-view video stream including a random access picture of a base view and at least one random access picture of a non-base view, each random access picture including a random access slice, the random access slice indicating a slice referring only to slices existing at a same time in a different view; receiving identification information indicating that the received multi-view video stream is a stereo video bitstream; obtaining flag information based on the identification information, the flag information indicating whether the random access picture of a base view is used for inter-view prediction of the random access picture of a non-base view; determining initialization information of a reference picture list of the random access picture of the non-base view based on the flag information; initializing the reference picture list of the random access picture of the non-base view using the initialization information; determining a prediction value of a macroblock in the random access picture of the non-base view based on the initialized reference picture list; and decoding the macroblock using the prediction value of the macroblock, wherein the base view indicates an independently decoded view without referring to a different view, and the non-base view indicates a view except the base view.
An annular-shaped disk half (50; 150; 250; 350) of a split friction disk assembly for a disk brake system comprising: a friction surface at an axial end of the disk half (50; 150; 250; 350); a non-friction surface (58; 158; 258; 358) at an axial end of the disk half (50; 150; 250; 350) on a side opposite of the friction surface, the non-friction surface (58; 158; 258; 358) including: a contact surface (60A; 60B; 260A; 260B); and a non-contact surface (62; 162; 262; 362) recessed from the contact surface (60A; 60B; 260A; 260B); an inner diameter surface at a radially inward facing edge of the disk half (50; 150; 250; 350); and an outer diameter surface at a radially outward facing edge of the disk half (50; 150; 250; 350); wherein the friction surface and non-friction surface (58; 158; 258; 358) extend radially between the inner diameter surface and the outer diameter surface; the friction surface for operationally engaging a corresponding friction surface of another disk brake system component; and the contact surface (60A; 60B; 260A; 260B) for contacting a non-friction surface (58; 158; 258; 358) of another disk brake system component, characterised by at least one attachment structure projecting radially outward from the outer diameter surface for contacting a wheel or projecting radially inward from the inner diameter surface for contacting a torque tube. a friction surface at an axial end of the disk half (50; 150; 250; 350); a non-friction surface (58; 158; 258; 358) at an axial end of the disk half (50; 150; 250; 350) on a side opposite of the friction surface, the non-friction surface (58; 158; 258; 358) including: a contact surface (60A; 60B; 260A; 260B); and a non-contact surface (62; 162; 262; 362) recessed from the contact surface (60A; 60B; 260A; 260B); a contact surface (60A; 60B; 260A; 260B); and a non-contact surface (62; 162; 262; 362) recessed from the contact surface (60A; 60B; 260A; 260B); an inner diameter surface at a radially inward facing edge of the disk half (50; 150; 250; 350); and an outer diameter surface at a radially outward facing edge of the disk half (50; 150; 250; 350); wherein the friction surface and non-friction surface (58; 158; 258; 358) extend radially between the inner diameter surface and the outer diameter surface; the friction surface for operationally engaging a corresponding friction surface of another disk brake system component; and the contact surface (60A; 60B; 260A; 260B) for contacting a non-friction surface (58; 158; 258; 358) of another disk brake system component, characterised by at least one attachment structure projecting radially outward from the outer diameter surface for contacting a wheel or projecting radially inward from the inner diameter surface for contacting a torque tube.
Method for identifying a telecommunications subscriber with the following steps: - Signalling (Step 0) a call from a second telecommunications device of a second telecommunications subscriber to a first telecommunications device of a first telecommunications subscriber; - Sending (Step II) first device information from the first telecommunications device to the second that indicates the components of subscriber data of the second telecommunications subscriber that the first telecommunications device wants to receive from the second telecommunications device. - Transmitting (Step III) subscriber data from the second telecommunications device to the first in accordance with the first device information. - Signalling (Step 0) a call from a second telecommunications device of a second telecommunications subscriber to a first telecommunications device of a first telecommunications subscriber; - Sending (Step II) first device information from the first telecommunications device to the second that indicates the components of subscriber data of the second telecommunications subscriber that the first telecommunications device wants to receive from the second telecommunications device. - Transmitting (Step III) subscriber data from the second telecommunications device to the first in accordance with the first device information.
A blower comprising: a main body extending in a longitudinal direction, a battery pack supporting member (2,2') arranged on the main body, and a battery pack arranged on the battery pack supporting member (2,2'), wherein the battery pack supporting member (2,2') is separable with respect to the main body, and comprises a seat for matching with the battery pack, a body forming a battery pack receiving portion to detachably arrange the battery pack thereon and a mounting portion being coupled with the main body, wherein the seat is disposed in the battery pack receiving portion and, the mounting portion comprising a clip portion, and the main body comprising a matching portion being coupled to the clip portion, and the clip portion is engaged with the matching portion to releasably attach the mounting portion to the main body, wherein the battery pack receiving portion comprises two sub-cavities, the two sub-cavities are symmetrically disposed on both two sides of a longitudinal axis of the main body, and each sub-cavity is assembled with the battery pack, characterized in that the battery pack supporting member (2,2') comprises a first portion, a second portion, and a third portion that are engaged with each other, the first portion and the second portion are jointly mounted to the main body, the first portion and the third portion constitute one sub-cavity, the second portion and the third portion constitute another sub-cavity. a main body extending in a longitudinal direction, a battery pack supporting member (2,2') arranged on the main body, and a battery pack arranged on the battery pack supporting member (2,2'), wherein the battery pack supporting member (2,2') is separable with respect to the main body, and comprises a seat for matching with the battery pack, a body forming a battery pack receiving portion to detachably arrange the battery pack thereon and a mounting portion being coupled with the main body, wherein the seat is disposed in the battery pack receiving portion and,