A compound having the formula or a stereochemically isomeric form thereof, wherein R 1 is C 1-6 alkyl; C 3-6 cycloalkyl; trifluoromethyl; C 1-3 alkyl substituted with trifluoromethyl, 2,2,2-trifluoroethoxy, C 3-7 cycloalkyl, phenyl, or phenyl substituted with C 1-3 alkyl, C 1-3 alkyloxy, cyano, halo, trifluoromethyl, or trifluoromethoxy; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of C 1-3 alkyl, C 1-3 alkyloxy, cyano, halo, trifluoromethyl, and trifluoromethoxy; or 4-tetrahydropyranyl; R 2 is cyano, halo, trifluoromethyl, C 1-3 alkyl or cyclopropyl; R 3 is a radical of formula (a) or (b) or (c) or (d) R 4 is hydrogen; hydroxyC 3-6 cycloalkyl; pyridinyl; pyridinyl substituted with one or two C 1-3 alkyl groups; pyrimidinyl; pyrimidinyl substituted with one or two C 1-3 alkyl groups; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of halo, C 1-3 alkyl, hydroxyC 1-3 alkyl, mono- or polyhaloC 1-3 alkyl, cyano, hydroxyl, amino, carboxyl, C 1-3 alkyloxyC 1-3 alkyl, C 1-3 alkyloxy, mono- or polyhalo-C 1-3 alkyloxy, C 1-3 alkylcarbonyl, mono- and di(C 1-3 alkyl)amino, and morpholinyl; or phenyl with two vicinal substituents which taken together form a bivalent radical of formula -N=CH-NH- (e), -CH=CH-NH- (f), or -O-CH 2 -CH 2 -NH- (g); R 5 is hydrogen, fluoro, hydroxyl, hydroxyC 1-3 alkyl, hydroxyC 1-3 alkyloxy, fluoroC 1-3 alkyl, fluoroC 1-3 alkyloxy, morpholinyl or cyano; X is C or N in which case R 5 represent the electron pair on N; or R 4 -X-R 5 represents a radical of formula (h) or (i) or (j) n is 0 or 1; q is 1 or 2; R 6 is C 1-3 alkyl; C 3-6 cycloalkyl; hydroxyC 2-4 alkyl; (C 3-6 cycloalkyl)C 1-3 alkyl; phenyl; pyridinyl; or phenyl or pyridinyl substituted with one or two substituents selected from the group consisting of halo, C 1-3 alkyl, C 1-3 alkoxy, hydroxyC 1-3 alkyl, trifluoromethyl and (CH 2) m -CO 2 H, wherein m = 0, 1, or 2; or R 6 is a cyclic radical of formula (k) wherein R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkyloxy, hydroxyC 1-3 alkyl; p is 1 or 2; Z is O, CH 2 or CR 9 wherein R 9 is hydrogen or C 1-3 alkyl; or R 8 and R 9 form a radical -CH 2 -CH 2 -; R 7 is hydrogen, halo or trifluoromethyl; Y is a covalent bond, O, NH, S, SO, SO 2, C (CH 3), -CH 2 -O-, -O-CH 2 -, CHF or CF 2; or R 6 -Y is morpholinyl, pyrrolidinyl, or piperidinyl optionally substituted with hydroxyl or hydroxyC 1-3 alkyl; and A is O or NH; or a pharmaceutically acceptable salt or a solvate thereof. R 1 is C 1-6 alkyl; C 3-6 cycloalkyl; trifluoromethyl; C 1-3 alkyl substituted with trifluoromethyl, 2,2,2-trifluoroethoxy, C 3-7 cycloalkyl, phenyl, or phenyl substituted with C 1-3 alkyl, C 1-3 alkyloxy, cyano, halo, trifluoromethyl, or trifluoromethoxy; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of C 1-3 alkyl, C 1-3 alkyloxy, cyano, halo, trifluoromethyl, and trifluoromethoxy; or 4-tetrahydropyranyl; R 2 is cyano, halo, trifluoromethyl, C 1-3 alkyl or cyclopropyl; R 3 is a radical of formula (a) or (b) or (c) or (d) R 4 is hydrogen; hydroxyC 3-6 cycloalkyl; pyridinyl; pyridinyl substituted with one or two C 1-3 alkyl groups; pyrimidinyl; pyrimidinyl substituted with one or two C 1-3 alkyl groups; phenyl; phenyl substituted with 1 or 2 substituents selected from the group consisting of halo, C 1-3 alkyl, hydroxyC 1-3 alkyl, mono- or polyhaloC 1-3 alkyl, cyano, hydroxyl, amino, carboxyl, C 1-3 alkyloxyC 1-3 alkyl, C 1-3 alkyloxy, mono- or polyhalo-C 1-3 alkyloxy, C 1-3 alkylcarbonyl, mono- and di(C 1-3 alkyl)amino, and morpholinyl; or phenyl with two vicinal substituents which taken together form a bivalent radical of formula -N=CH-NH- (e), -CH=CH-NH- (f), or -O-CH 2 -CH 2 -NH- (g); R 5 is hydrogen, fluoro, hydroxyl, hydroxyC 1-3 alkyl, hydroxyC 1-3 alkyloxy, fluoroC 1-3 alkyl, fluoroC 1-3 alkyloxy, morpholinyl or cyano; X is C or N in which case R 5 represent the electron pair on N; or R 4 -X-R 5 represents a radical of formula (h) or (i) or (j) n is 0 or 1; q is 1 or 2; n is 0 or 1; q is 1 or 2; R 6 is C 1-3 alkyl; C 3-6 cycloalkyl; hydroxyC 2-4 alkyl; (C 3-6 cycloalkyl)C 1-3 alkyl; phenyl; pyridinyl; or phenyl or pyridinyl substituted with one or two substituents selected from the group consisting of halo, C 1-3 alkyl, C 1-3 alkoxy, hydroxyC 1-3 alkyl, trifluoromethyl and (CH 2) m -CO 2 H, wherein m = 0, 1, or 2; or R 6 is a cyclic radical of formula (k) wherein R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkyloxy, hydroxyC 1-3 alkyl; p is 1 or 2; Z is O, CH 2 or CR 9 wherein R 9 is hydrogen or C 1-3 alkyl; or R 8 and R 9 form a radical -CH 2 -CH 2 -; wherein R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkyloxy, hydroxyC 1-3 alkyl; p is 1 or 2; Z is O, CH 2 or CR 9 wherein R 9 is hydrogen or C 1-3 alkyl; or R 8 and R 9 form a radical -CH 2 -CH 2 -; R 7 is hydrogen, halo or trifluoromethyl; Y is a covalent bond, O, NH, S, SO, SO 2, C (CH 3), -CH 2 -O-, -O-CH 2 -, CHF or CF 2; or R 6 -Y is morpholinyl, pyrrolidinyl, or piperidinyl optionally substituted with hydroxyl or hydroxyC 1-3 alkyl; and A is O or NH;