A system, comprising: an ablation device (1310, 1310') including a set of electrodes configured to be positioned within patient anatomy; a signal generator including: an energy source coupled to the set of electrodes; and sensing circuitry (720, 725) coupled to the set of electrodes; and a processor operatively coupled to the energy source and the sensing circuitry (720, 725), the processor configured to: generate, using the energy source, a set of pre-ablation signals; deliver the set of pre-ablation signals to a first set of subsets of electrodes of the set of electrodes; measure, using the sensing circuitry (720, 725), a set of one or more currents passing through a current sense resistor of the sensing circuitry (720, 725) in response to the delivery of the set of pre-ablation signals; determine whether the set of currents meet a predetermined criterion by: calculating a metric based on at least one of: an average value of the set of currents, a variance of the set of currents, or a ratio of a maximum current to a minimum current of the set of currents; and determining whether the metric is less than or greater than a threshold value; and in response to determining that the set of currents meet the predetermined criterion, generate and deliver a pulse waveform to a second set of subsets of electrodes of the set of electrodes such that the second set of subsets of electrodes generates a pulsed electric field for ablating tissue. an ablation device (1310, 1310') including a set of electrodes configured to be positioned within patient anatomy; a signal generator including: an energy source coupled to the set of electrodes; and sensing circuitry (720, 725) coupled to the set of electrodes; and an energy source coupled to the set of electrodes; and sensing circuitry (720, 725) coupled to the set of electrodes; and a processor operatively coupled to the energy source and the sensing circuitry (720, 725), the processor configured to: generate, using the energy source, a set of pre-ablation signals; deliver the set of pre-ablation signals to a first set of subsets of electrodes of the set of electrodes; measure, using the sensing circuitry (720, 725), a set of one or more currents passing through a current sense resistor of the sensing circuitry (720, 725) in response to the delivery of the set of pre-ablation signals; determine whether the set of currents meet a predetermined criterion by: calculating a metric based on at least one of: an average value of the set of currents, a variance of the set of currents, or a ratio of a maximum current to a minimum current of the set of currents; and determining whether the metric is less than or greater than a threshold value; and in response to determining that the set of currents meet the predetermined criterion, generate and deliver a pulse waveform to a second set of subsets of electrodes of the set of electrodes such that the second set of subsets of electrodes generates a pulsed electric field for ablating tissue. generate, using the energy source, a set of pre-ablation signals; deliver the set of pre-ablation signals to a first set of subsets of electrodes of the set of electrodes; measure, using the sensing circuitry (720, 725), a set of one or more currents passing through a current sense resistor of the sensing circuitry (720, 725) in response to the delivery of the set of pre-ablation signals; determine whether the set of currents meet a predetermined criterion by: calculating a metric based on at least one of: an average value of the set of currents, a variance of the set of currents, or a ratio of a maximum current to a minimum current of the set of currents; and determining whether the metric is less than or greater than a threshold value; and calculating a metric based on at least one of: an average value of the set of currents, a variance of the set of currents, or a ratio of a maximum current to a minimum current of the set of currents; and determining whether the metric is less than or greater than a threshold value; and in response to determining that the set of currents meet the predetermined criterion, generate and deliver a pulse waveform to a second set of subsets of electrodes of the set of electrodes such that the second set of subsets of electrodes generates a pulsed electric field for ablating tissue.