A D-proline of the Formula: wherein R is and the group R 1 is hydrogen or halogen; X-Y-X' is an optionally substituted linker having from 4-20 linear or straight-chain carbon atoms, wherein X is -(CH 2) n -; -CH(R 2)(CH 2) n -; CH 2 O(CH 2) n -; CH 2 NH-; benzyl, -C(R 2)=CH-; -CH 2 CH -; or thiazol-2,5-diyl; Y is -S-S-; -(CH 2) n -; -O-; -NH-; -N(R 2)-; -CH=CH-; -NHC NH-;-N(R 2)C N(R 2)-;-N[CH 2 C 6 H 3 (OCH 3) 2]-; -N(CH 2 C 6 H 5)-; -N(CH 2 C 6 H 5)C N(CH 2 C 6 H 5)-; -N(alkoxyalkyl)-; N(cycloalkyl-methyl)-; 2,6-pyridyl; 2,5-furanyl; 2,5-thienyl; 1,2-cyclohexyl; 1,3-cyclohexyl; 1,4-cyclohexyl; 1,2-naphthyl; 1,4-naphthyl; 1,5-naphthyl; 1,6-naphthyl; biphenylen; or 1,2-phenylen, 1,3-phenylen and 1,4-phenylen, wherein the phenylen groups are optionally substituted by 1-4 substituents, selected from halogen, lower alkyl, lower alkoxy, hydroxyl, carboxy, -COO-lower alkyl, nitrilo, 5-tetrazol, (2-carboxylic acid pyrrolidin-1-yl)-2-oxo-ethoxy, N-hydroxycarbamimiodyl, 5-oxo[1,2,4oxadiazolyl, 2-oxo [1,2,3,5] oxathiadiazolyl, 5-thioxo[1,2,4]oxadiazolyl and 5-tert-butylsulfanyl-[1,2,4]oxadiazolyl; and, X' is -(CH 2) n -; -(CH 2) n CH(R 2)-; -(CH 2) n OCH 2 -; -NHCH 2 -; benzyl, -CH=C(R 2)-; CH CH 2; or thiazol-2,5-diyl; R 2 is lower alkyl, lower alkoxy or benzyl and n is 0-3, or a pharmaceutically acceptable salt or mono- or diester thereof, which depletes serum amyloid P component from the circulation and an antibody specific for serum amyloid P component, for simultaneous, simultaneous separate or sequential use in the treatment or prophylaxis of amyloid disease. R 1 is hydrogen or halogen; X-Y-X' is an optionally substituted linker having from 4-20 linear or straight-chain carbon atoms, wherein X is -(CH 2) n -; -CH(R 2)(CH 2) n -; CH 2 O(CH 2) n -; CH 2 NH-; benzyl, -C(R 2)=CH-; -CH 2 CH -; or thiazol-2,5-diyl; Y is -S-S-; -(CH 2) n -; -O-; -NH-; -N(R 2)-; -CH=CH-; -NHC NH-;-N(R 2)C N(R 2)-;-N[CH 2 C 6 H 3 (OCH 3) 2]-; -N(CH 2 C 6 H 5)-; -N(CH 2 C 6 H 5)C N(CH 2 C 6 H 5)-; -N(alkoxyalkyl)-; N(cycloalkyl-methyl)-; 2,6-pyridyl; 2,5-furanyl; 2,5-thienyl; 1,2-cyclohexyl; 1,3-cyclohexyl; 1,4-cyclohexyl; 1,2-naphthyl; 1,4-naphthyl; 1,5-naphthyl; 1,6-naphthyl; biphenylen; or 1,2-phenylen, 1,3-phenylen and 1,4-phenylen, wherein the phenylen groups are optionally substituted by 1-4 substituents, selected from halogen, lower alkyl, lower alkoxy, hydroxyl, carboxy, -COO-lower alkyl, nitrilo, 5-tetrazol, (2-carboxylic acid pyrrolidin-1-yl)-2-oxo-ethoxy, N-hydroxycarbamimiodyl, 5-oxo[1,2,4oxadiazolyl, 2-oxo [1,2,3,5] oxathiadiazolyl, 5-thioxo[1,2,4]oxadiazolyl and 5-tert-butylsulfanyl-[1,2,4]oxadiazolyl; and, X' is -(CH 2) n -; -(CH 2) n CH(R 2)-; -(CH 2) n OCH 2 -; -NHCH 2 -; benzyl, -CH=C(R 2)-; CH CH 2; or thiazol-2,5-diyl; X is -(CH 2) n -; -CH(R 2)(CH 2) n -; CH 2 O(CH 2) n -; CH 2 NH-; benzyl, -C(R 2)=CH-; -CH 2 CH -; or thiazol-2,5-diyl; Y is -S-S-; -(CH 2) n -; -O-; -NH-; -N(R 2)-; -CH=CH-; -NHC NH-;-N(R 2)C N(R 2)-;-N[CH 2 C 6 H 3 (OCH 3) 2]-; -N(CH 2 C 6 H 5)-; -N(CH 2 C 6 H 5)C N(CH 2 C 6 H 5)-; -N(alkoxyalkyl)-; N(cycloalkyl-methyl)-; 2,6-pyridyl; 2,5-furanyl; 2,5-thienyl; 1,2-cyclohexyl; 1,3-cyclohexyl; 1,4-cyclohexyl; 1,2-naphthyl; 1,4-naphthyl; 1,5-naphthyl; 1,6-naphthyl; biphenylen; or 1,2-phenylen, 1,3-phenylen and 1,4-phenylen, wherein the phenylen groups are optionally substituted by 1-4 substituents, selected from halogen, lower alkyl, lower alkoxy, hydroxyl, carboxy, -COO-lower alkyl, nitrilo, 5-tetrazol, (2-carboxylic acid pyrrolidin-1-yl)-2-oxo-ethoxy, N-hydroxycarbamimiodyl, 5-oxo[1,2,4oxadiazolyl, 2-oxo [1,2,3,5] oxathiadiazolyl, 5-thioxo[1,2,4]oxadiazolyl and 5-tert-butylsulfanyl-[1,2,4]oxadiazolyl; and, X' is -(CH 2) n -; -(CH 2) n CH(R 2)-; -(CH 2) n OCH 2 -; -NHCH 2 -; benzyl, -CH=C(R 2)-; CH CH 2; or thiazol-2,5-diyl; R 2 is lower alkyl, lower alkoxy or benzyl and n is 0-3, or a pharmaceutically acceptable salt or mono- or diester thereof, which depletes serum amyloid P component from the circulation and an antibody specific for serum amyloid P component, for simultaneous, simultaneous separate or sequential use in the treatment or prophylaxis of amyloid disease.