A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, R 3, R 4 and R 5 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl; R 6 is hydrogen, alkyl group having one to six carbon atoms, or halo; R 7 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R 8 is hydroxyl, formyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, -COR 9, -CO 2 R 9, -CONR 9 R 10, -C(NR 11)NR 9 R 10, -C NR 9 R 10, -SO 2 R 9, or -SO 2 NR 9 R 10, where R 9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; and R 10 and R 11 are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 9 and R 10 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; or R 7 and R 8 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; wherein an aryl is a six membered carbocyclic aromatic ring, a bicyclic ring system wherein at least one ring is carbocyclic and aromatic, or a tricyclic ring system wherein at least one ring is carbocyclic and aromatic; and a heteroaryl refers to a 5 to 7 membered aromatic monocyclic ring containing one or more heteroatoms chosen from N, O and S, a bicyclic heterocycloalkyl containing one or more heteroatoms chosen from N, O and S wherein at least one heteroatom is present in the aromatic ring or a tricyclic heterocycloalkyl containing one or more heteroatoms chosen from N, O and S wherein at least one heteroatom is present in the aromatic ring. R 1, R 2, R 3, R 4 and R 5 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl; R 6 is hydrogen, alkyl group having one to six carbon atoms, or halo; R 7 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R 8 is hydroxyl, formyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, -COR 9, -CO 2 R 9, -CONR 9 R 10, -C(NR 11)NR 9 R 10, -C NR 9 R 10, -SO 2 R 9, or -SO 2 NR 9 R 10, where R 9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; and R 10 and R 11 are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 9 and R 10 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; or R 7 and R 8 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring; wherein