A time-temperature indication device (100, 200, 300, 400, 500), comprising: a first element (102, 202, 302, 402, 502) comprising a substrate film (108, 208, 208', 408, 508) carrying a first reactant layer (112, 212, 212', 312, 412, 512); a second element (104, 204, 304, 404) comprising a carrier film (122, 122', 222, 422) having at least one pressable section (124, 124', 224, 324), said pressable section (124, 124', 224, 324) carrying a second reactant layer (126, 126', 226, 326, 426, 526) on at least a portion thereof, the second reactant layer (126, 126', 226, 326, 426, 526) configured to adhere to the first reactant layer (112, 212, 212', 312, 412, 512); a spacer (106, 206, 306, 406, 506) configured to separate between the first element (102, 202, 302, 402, 502) and the second element (104, 204, 304, 404), and having a hollow activation zone (130, 230, 330, 430, 530) substantially aligned with said at least one pressable section (124, 124', 224, 324); the device (100, 200, 300, 400, 500) having a non-activated state, in which the first reactant layer (112, 212, 212', 312, 412, 512) and the second reactant layer (126, 126', 226, 326, 426, 526) are non-contacted, and an activated state, in which said second reactant layer (126, 126', 226, 326, 426, 526) is adhered to at least a portion of said first reactant layer (112, 212, 212', 312, 412, 512) to enable a reaction therebetween that causes at least one substantially irreversible change in physical property of the device (100, 200, 300, 400, 500), said reaction being indicative to time-temperature history of the device, the device (100, 200, 300, 400, 500) being switchable from the non-activated state to the activated state by displacing the pressable section (124, 124', 224, 324) into the hollow activation zone (130, 230, 330, 430, 530) towards said first element (102, 202, 302, 402, 502) to cause adhering of the second reactant layer (126, 126', 226, 326, 426, 526) to the first reactant layer (112, 212, 212', 312, 412, 512). a first element (102, 202, 302, 402, 502) comprising a substrate film (108, 208, 208', 408, 508) carrying a first reactant layer (112, 212, 212', 312, 412, 512); a second element (104, 204, 304, 404) comprising a carrier film (122, 122', 222, 422) having at least one pressable section (124, 124', 224, 324), said pressable section (124, 124', 224, 324) carrying a second reactant layer (126, 126', 226, 326, 426, 526) on at least a portion thereof, the second reactant layer (126, 126', 226, 326, 426, 526) configured to adhere to the first reactant layer (112, 212, 212', 312, 412, 512); a spacer (106, 206, 306, 406, 506) configured to separate between the first element (102, 202, 302, 402, 502) and the second element (104, 204, 304, 404), and having a hollow activation zone (130, 230, 330, 430, 530) substantially aligned with said at least one pressable section (124, 124', 224, 324); the device (100, 200, 300, 400, 500) having a non-activated state, in which the first reactant layer (112, 212, 212', 312, 412, 512) and the second reactant layer (126, 126', 226, 326, 426, 526) are non-contacted, and an activated state, in which said second reactant layer (126, 126', 226, 326, 426, 526) is adhered to at least a portion of said first reactant layer (112, 212, 212', 312, 412, 512) to enable a reaction therebetween that causes at least one substantially irreversible change in physical property of the device (100, 200, 300, 400, 500), said reaction being indicative to time-temperature history of the device, the device (100, 200, 300, 400, 500) being switchable from the non-activated state to the activated state by displacing the pressable section (124, 124', 224, 324) into the hollow activation zone (130, 230, 330, 430, 530) towards said first element (102, 202, 302, 402, 502) to cause adhering of the second reactant layer (126, 126', 226, 326, 426, 526) to the first reactant layer (112, 212, 212', 312, 412, 512).