mhurhangee/ep-ind-claims huggingface dataset:
An anti-CD47 agent for use in a method of treating cancer in a human subject, the method comprising: (a) administering a priming dose of the anti-CD47 agent to the subject, where the priming dose is from 0.5 to 5 mg/kg, wherein the priming dose is administered to the human subject in an infusate with a concentration of from 0.05 mg/ml to 0.5 mg/ml anti-CD47 agent, wherein the infusate is delivered over a period of at least 3 hours, and wherein the priming dose leads to hemagglutination immediately following infusion, and (b) administering a therapeutically effective dose of the anti-CD47 agent to the subject, wherein the therapeutically effective dose is 10-40 mg/kg, wherein step (b) is 3-10 days after beginning step (a), wherein the priming dose primes the subject for administration of the therapeutically effective dose of anti-CD47 antibody such that the therapeutically effective dose does not result in a severe loss of red blood cells, wherein the anti-CD47 agent is an anti-CD47 IgG4 antibody that blocks the interaction between CD47 and SIRPα, and wherein: (i) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (ii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (iii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: (a) administering a priming dose of the anti-CD47 agent to the subject, where the priming dose is from 0.5 to 5 mg/kg, wherein the priming dose is administered to the human subject in an infusate with a concentration of from 0.05 mg/ml to 0.5 mg/ml anti-CD47 agent, wherein the infusate is delivered over a period of at least 3 hours, and wherein the priming dose leads to hemagglutination immediately following infusion, and (b) administering a therapeutically effective dose of the anti-CD47 agent to the subject, wherein the therapeutically effective dose is 10-40 mg/kg, wherein step (b) is 3-10 days after beginning step (a), wherein the priming dose primes the subject for administration of the therapeutically effective dose of anti-CD47 antibody such that the therapeutically effective dose does not result in a severe loss of red blood cells, wherein the anti-CD47 agent is an anti-CD47 IgG4 antibody that blocks the interaction between CD47 and SIRPα, and wherein: (i) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (ii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (iii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: (i) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (ii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence: or (iii) the VL domain of the antibody has the sequence: and the VH domain of the antibody has the sequence:
High pressure cleaning appliance with an axial piston pump, which comprises at least one linearly moveable piston (36, 38), and with an electric motor, which comprises a motor shaft and is coupled to the axial piston pump by way of a transmission, a drive shaft and a swash plate, wherein the axial piston pump is arranged offset from the motor shaft in the radial direction in relation to a longitudinal axis of the motor shaft, wherein the linear movement of the at least one piston (36, 38) is oriented in parallel to the longitudinal axis of the motor shaft and the motor shaft in combination with the transmission and the drive shaft forms a U-shaped drive train, characterized in that the electric motor comprises a bearing shield on which the motor shaft is rotatably mounted, wherein the bearing shield is held on a support part on which the drive shaft is rotatably mounted.
A compound of Formula III: wherein R 8 is NH 2, OMe, OCH 2 CH 3 or =O; and R 9 is NH 2, H, or F; or a pharmaceutically acceptable salt, solvate, or ester thereof. R 8 is NH 2, OMe, OCH 2 CH 3 or =O; and R 9 is NH 2, H, or F;
An arthrodesis plate for joint fusion, wherein the arthrodesis plate comprises: a proximal-distal direction, a longitudinal direction in the proximal-distal direction, and a medio-lateral direction, a proximal anchoring region and a distal anchoring region which are mechanically and rigidly connected to each other, wherein a transversal cross-section of the anchoring regions has a height (h) relative to the longitudinal direction and has a width (b) in the medio-lateral direction, wherein the width is greater than the height, characterized in that the proximal anchoring region and the distal anchoring region have an outer contour (10, 12) with an undulating cross-section in a plane parallel to the sagittal plane and/or in a transversal plane, and in that the anchoring regions (4, 6) can be introduced in a medio-lateral direction into a planar slot, wherein the undulating cross-section is arranged to press with its crests into the boundary surfaces of the planar slot. a proximal-distal direction, a longitudinal direction in the proximal-distal direction, and a medio-lateral direction, a proximal anchoring region and a distal anchoring region which are mechanically and rigidly connected to each other, wherein a transversal cross-section of the anchoring regions has a height (h) relative to the longitudinal direction and has a width (b) in the medio-lateral direction, wherein the width is greater than the height, characterized in that the proximal anchoring region and the distal anchoring region have an outer contour (10, 12) with an undulating cross-section in a plane parallel to the sagittal plane and/or in a transversal plane, and in that the anchoring regions (4, 6) can be introduced in a medio-lateral direction into a planar slot, wherein the undulating cross-section is arranged to press with its crests into the boundary surfaces of the planar slot.
An in vitro prostate carcinoma determination method, comprising: determining a ratio of an amount of free prostate specific antigen (hereinafter, the prostate specific antigen is referred to as "PSA") having a glycan of which a terminal sialic acid residue is α(2,3)-linked to a second galactose residue from a terminal of the glycan (hereinafter, referred to as "α(2,3) free PSA") to an amount of free PSA in a biological sample; and determining that prostate carcinoma is developed or the probability of developing prostate carcinoma is high in the case where the ratio is 40% or higher. determining a ratio of an amount of free prostate specific antigen (hereinafter, the prostate specific antigen is referred to as "PSA") having a glycan of which a terminal sialic acid residue is α(2,3)-linked to a second galactose residue from a terminal of the glycan (hereinafter, referred to as "α(2,3) free PSA") to an amount of free PSA in a biological sample; and determining that prostate carcinoma is developed or the probability of developing prostate carcinoma is high in the case where the ratio is 40% or higher.
A dosage form dispenser, comprising: • a casing comprising a first portion adapted for insertion within an oral cavity of a subject and a second portion adapted to encase a dosage form dispensing mechanism located therewithin; • at least one camera (30, 50, 70, 90) contained on or within the dosage form dispenser and positioned on said second portion of said casing, and further positioned to capture a field of view (40, 60) of a portion of a face of a subject, wherein said field of view (40, 60) comprises at least a portion of a base view of the nose of said subject, the at least one camera (30, 50, 70, 90) configured to capture the field of view (40, 60) while the first portion is located within the oral cavity of the subject; and • a dosage form dispensing mechanism; characterized by • a microprocessor and associated memory for processing and storing user authentication information, comparing images relayed from said at least one camera to at least one stored user standard and providing authentication when a match is established; and • an interface connected to said dispensing mechanism, which promotes dispensing said dosage form when said authentication has been obtained. • a casing comprising a first portion adapted for insertion within an oral cavity of a subject and a second portion adapted to encase a dosage form dispensing mechanism located therewithin; • at least one camera (30, 50, 70, 90) contained on or within the dosage form dispenser and positioned on said second portion of said casing, and further positioned to capture a field of view (40, 60) of a portion of a face of a subject, wherein said field of view (40, 60) comprises at least a portion of a base view of the nose of said subject, the at least one camera (30, 50, 70, 90) configured to capture the field of view (40, 60) while the first portion is located within the oral cavity of the subject; and • a dosage form dispensing mechanism; • a microprocessor and associated memory for processing and storing user authentication information, comparing images relayed from said at least one camera to at least one stored user standard and providing authentication when a match is established; and • an interface connected to said dispensing mechanism, which promotes dispensing said dosage form when said authentication has been obtained.
A rotating electrical machine comprising: a three-phase coil including a U-phase coil, a V-phase coil, and a W-phase coil each formed of a flat wire; a neutral point bus bar forming a neutral point of the three-phase coil and formed of a conductive plate; and a temperature detector configured to detect a temperature of the three-phase coil, wherein the neutral point bus bar is formed in an arc shape along an outer periphery of the three-phase coil, one end of one coil in the three-phase coil is connected to a vicinity of a center of the neutral point bus bar in a circumferential direction thereof, one end of each of remaining two coils in the three-phase coil is connected to a vicinity of an end of the neutral point bus bar in the circumferential direction, the temperature detector is attached to a position facing the one end of the one coil in the vicinity of the center of the neutral point bus bar, characterized in that the neutral point bus bar includes a recess recessed radially inward, and the temperature detector is provided in the recess at a position facing the one end of the one coil with the neutral point bus bar sandwitched. a neutral point bus bar forming a neutral point of the three-phase coil and formed of a conductive plate; and a temperature detector configured to detect a temperature of the three-phase coil, wherein the neutral point bus bar is formed in an arc shape along an outer periphery of the three-phase coil, one end of one coil in the three-phase coil is connected to a vicinity of a center of the neutral point bus bar in a circumferential direction thereof, one end of each of remaining two coils in the three-phase coil is connected to a vicinity of an end of the neutral point bus bar in the circumferential direction, the temperature detector is attached to a position facing the one end of the one coil in the vicinity of the center of the neutral point bus bar, characterized in that the neutral point bus bar includes a recess recessed radially inward, and the temperature detector is provided in the recess at a position facing the one end of the one coil with the neutral point bus bar sandwitched.
A process for removing acid decomposable salts from a processing liquid used to prevent gas hydrate formation in oil and gas well operations, said process comprising: introducing the processing liquid containing acid decomposable salts into a heat exchanger to heat said processing liquid; passing the heated processing liquid into a first degassing vessel operated under reduced pressure to remove entrained gases from said processing liquid; and further introducing a sweep gas into said first degassing vessel to remove entrained gases, wherein the entrained gases released from the processing liquid comprise entrained acid gases, as well as volatile hydrocarbons and other volatile gases; wherein the gases released from the degassing vessel are maintained in an oxygen free state; introducing an acid into the processing liquid removed from the first degassing vessel containing acid decomposable salts to produce an acid/processing liquid mixture; introducing said mixture into a second degassing vessel wherein decomposition gases formed by the reaction of said acids and said acid decomposable salts are removed; and removing said decomposition gases from said second degassing vessel; and removing processing liquid from said second degassing vessel substantially free of said acid decomposable salts. introducing the processing liquid containing acid decomposable salts into a heat exchanger to heat said processing liquid; passing the heated processing liquid into a first degassing vessel operated under reduced pressure to remove entrained gases from said processing liquid; and further introducing a sweep gas into said first degassing vessel to remove entrained gases, wherein the entrained gases released from the processing liquid comprise entrained acid gases, as well as volatile hydrocarbons and other volatile gases; wherein the gases released from the degassing vessel are maintained in an oxygen free state; introducing an acid into the processing liquid removed from the first degassing vessel containing acid decomposable salts to produce an acid/processing liquid mixture; introducing said mixture into a second degassing vessel wherein decomposition gases formed by the reaction of said acids and said acid decomposable salts are removed; and removing said decomposition gases from said second degassing vessel; and removing processing liquid from said second degassing vessel substantially free of said acid decomposable salts.
A method for transmitting information data by using a Reed-Muller, RM, coding scheme in a wireless communication system, the method comprising: configuring a number of resource elements for transmitting the information data; generating coded information data having a specific bit size by applying RM coding to the information data; performing rate matching to the coded information data so that the rate matched information data fits into the calculated number of resource elements; and transmitting the rate-matched information data by using the calculated number of resource elements, wherein: - a minimum value for the number of resource elements is decided by Q ′ min = ⌈ 2 × O Q m ⌉; - O is a bit size of the information data and Q m is a modulation order, wherein the information data consists of Acknowledgment/Negative Acknowledgment, ACK/NACK, or Rank information, RI. configuring a number of resource elements for transmitting the information data; generating coded information data having a specific bit size by applying RM coding to the information data; performing rate matching to the coded information data so that the rate matched information data fits into the calculated number of resource elements; and transmitting the rate-matched information data by using the calculated number of resource elements, wherein: - a minimum value for the number of resource elements is decided by Q ′ min = ⌈ 2 × O Q m ⌉; - O is a bit size of the information data and Q m is a modulation order, - a minimum value for the number of resource elements is decided by Q ′ min = ⌈ 2 × O Q m ⌉; - O is a bit size of the information data and Q m is a modulation order, wherein the information data consists of Acknowledgment/Negative Acknowledgment, ACK/NACK, or Rank information, RI.
A cell suspension comprising expanded autologous or allogeneic mesenchymal stromal cells (MSCs) derived from the bone marrow of a human subject, wherein said MSCs are suspended in plasma obtained from the peripheral blood from a patient or subject to be treated with the cell suspension, for use in the treatment or amelioration of a disease with cerebral impaired glucose metabolism, wherein said cell suspension is administered to the patient via intrathecal (through an intrathecal administration in the cerebrospinal fluid of the subarachnoid space), in particular by lumbar puncture, and wherein the disease with cerebral impaired glucose metabolism is Alzheimer's disease.
A method in a wireless device of performing at least one intra-frequency radio measurement on at least one carrier frequency f1 in a first set of time resources and at least one inter-frequency radio measurement on at least one carrier frequency f2 in a second set of time resources, wherein at least one of f1 and f2 is operating under a flexible frame structure, the method comprising: obtaining the first set of time resources associated with the intra-frequency radio measurement; obtaining the second set of time resources associated with the inter-frequency radio measurement; determining a priority of the inter-frequency measurement with respect to the intra-frequency measurement based on an amount of overlap between the first and the second sets of time resources; and performing the intra-frequency and the inter-frequency measurements using the determined priority. obtaining the first set of time resources associated with the intra-frequency radio measurement; obtaining the second set of time resources associated with the inter-frequency radio measurement; determining a priority of the inter-frequency measurement with respect to the intra-frequency measurement based on an amount of overlap between the first and the second sets of time resources; and performing the intra-frequency and the inter-frequency measurements using the determined priority.
A female component for a tubular hydrocarbon working string subjected to dynamic bending strength, comprising a tapered female threading for cooperation with a male threading in order to form a rigid mutual connection of tubular elements, a free end and a female sealing surface being disposed between the free end and the female threading, the female sealing surface being intended to come into contact in the made up condition with a male sealing surface in order to form a metal-metal seal, characterized in that it comprises an annular groove provided between the free end and the female sealing surface, leaving an axial distance greater than zero between the free end and a transition region outwardly of the female sealing surface, and a radial distance greater than zero between the female sealing surface and a chamfer of the free end, the groove comprising a border formed by the chamfer and a border formed by a portion of the transition region, in order to protect the female sealing surface prior to makeup.
Method for additive manufacture of a three-dimensional object wherein a digital model of the three-dimensional object is provided, wherein at least one starting area (SF1, SF2) is defined on a surface of the digital model and, beginning on said at least one starting area (SF1, SF2), a layered subdivision of the model takes place, wherein the layers (SI to Sn) are successively built up additively to produce the three-dimensional object, characterised in that, in order to determine the positioning and arrangement of the layers (SI to Sn), at least one distance field is calculated, which assigns to each point of the digital model volume, according to a defining distance function, the shortest distance to a nearest starting area (SF1, SF2), wherein the layers (SI to Sn) are each determined from at least one isosurface, wherein the points of an isosurface have the same distance value and thus have the same distance to the nearest starting area (SF1, SF2), wherein, for each discrete point of a layer (S1 to Sn) defined by the isosurfaces of the distance field, an orientation of the processing head is determined, wherein either the surface normal of the layer (S1 to Sn) is calculated or the gradient vectors of the distance field are calculated, which show the direction of the steepest rise in the distances for the discrete point, wherein the shape and distribution of the isosurfaces and layers (S1 to Sn) are adapted to the shape of the digital model and wherein the distance values of the isosurfaces predetermine the sequence of the layers for additive construction.
A film suitable for applications requiring enhanced water vapor transmission rates, said film comprising a formulated compound comprising: a) a polyolefin polymer; wherein the polyolefin polymer is a polyethylene or polypropylene homopolymer or random copolymer or block copolymer; b) from 1 to 50 percent by weight of the film of a hydrophilic polymer; and c) from 30 to 85 percent by weight of a filler with a hydrophilic surface functionality and having a water contact angle of 20° or less, and wherein the film has a thickness of 150 μm (microns) or less. a) a polyolefin polymer; wherein the polyolefin polymer is a polyethylene or polypropylene homopolymer or random copolymer or block copolymer; b) from 1 to 50 percent by weight of the film of a hydrophilic polymer; and c) from 30 to 85 percent by weight of a filler with a hydrophilic surface functionality and having a water contact angle of 20° or less, and wherein the film has a thickness of 150 μm (microns) or less.
A system for optically powering a network component that processes an input signal, comprising: a circuit including a VCSEL (6; 33); an optical power source located remotely with respect to said circuit; an optical fiber coupled to said power source that conducts optical power to said circuit, and an optical-electro converter (8; 31) for converting optical power from said power source via said fiber into a biasing current, wherein said VCSEL (6; 33) is biased by an electrical current generated by light from said optical power source and includes an input that receives said input signal and an output that provides an optical output signal, and wherein said circuit includes a bias tee connected to said biasing current, said input signal and said VCSEL input such that said output is a beam of modulated laser light generated by said VCSEL (6; 33). a circuit including a VCSEL (6; 33); an optical power source located remotely with respect to said circuit; an optical fiber coupled to said power source that conducts optical power to said circuit, and an optical-electro converter (8; 31) for converting optical power from said power source via said fiber into a biasing current, wherein said VCSEL (6; 33) is biased by an electrical current generated by light from said optical power source and includes an input that receives said input signal and an output that provides an optical output signal, and wherein said circuit includes a bias tee connected to said biasing current, said input signal and said VCSEL input such that said output is a beam of modulated laser light generated by said VCSEL (6; 33).
A transfer material, comprising: a coloring material-receiving layer; a releasing layer; and a base material sheet, wherein the transfer material has a laminated structure in which the base material sheet, the releasing layer and the coloring material-receiving layer are sequentially laminated, wherein the coloring material-receiving layer contains at least inorganic fine particles, a water-soluble resin, and a cationic resin, and wherein the coloring material-receiving layer is capable of being thermally pressure-bonded onto an image support and is separable from the releasing layer, characterized in that a weight-average molecular weight of the cationic resin is 1,000 to 15,000. a coloring material-receiving layer; a releasing layer; and a base material sheet, wherein the transfer material has a laminated structure in which the base material sheet, the releasing layer and the coloring material-receiving layer are sequentially laminated, wherein the coloring material-receiving layer contains at least inorganic fine particles, a water-soluble resin, and a cationic resin, and wherein the coloring material-receiving layer is capable of being thermally pressure-bonded onto an image support and is separable from the releasing layer, characterized in that a weight-average molecular weight of the cationic resin is 1,000 to 15,000.