A system for constructing fluoroscopic-based three dimensional volumetric data from two dimensional fluoroscopic images, comprising: a computing device configured to facilitate the navigation of a medical device to a target area; wherein the computing device is further configured to: receive a fluoroscopic video of the target area captured by a fluoroscopic imaging device; determine a pose of the fluoroscopic imaging device for each frame of the fluoroscopic video; and characterized in that the computing device is further configured to: construct, from the fluoroscopic video and the pose determined for each frame of the fluoroscopic video, fluoroscopic-based three dimensional volumetric data of the target area; and utilize the fluoroscopic-based three dimensional volumetric data for at least one of: locally registering between the fluoroscopic-based three dimensional volumetric data and previously acquired CT volumetric data in the proximity of the target area; correcting three dimensional relation of the medical device to the target area; or transforming three dimensional positions of features in the fluoroscopic video from fluoroscope coordinates into a navigation system coordinates for the target area. a computing device configured to facilitate the navigation of a medical device to a target area; wherein the computing device is further configured to: receive a fluoroscopic video of the target area captured by a fluoroscopic imaging device; determine a pose of the fluoroscopic imaging device for each frame of the fluoroscopic video; and characterized in that the computing device is further configured to: construct, from the fluoroscopic video and the pose determined for each frame of the fluoroscopic video, fluoroscopic-based three dimensional volumetric data of the target area; and utilize the fluoroscopic-based three dimensional volumetric data for at least one of: locally registering between the fluoroscopic-based three dimensional volumetric data and previously acquired CT volumetric data in the proximity of the target area; correcting three dimensional relation of the medical device to the target area; or transforming three dimensional positions of features in the fluoroscopic video from fluoroscope coordinates into a navigation system coordinates for the target area. receive a fluoroscopic video of the target area captured by a fluoroscopic imaging device; determine a pose of the fluoroscopic imaging device for each frame of the fluoroscopic video; and characterized in that the computing device is further configured to: construct, from the fluoroscopic video and the pose determined for each frame of the fluoroscopic video, fluoroscopic-based three dimensional volumetric data of the target area; and utilize the fluoroscopic-based three dimensional volumetric data for at least one of: locally registering between the fluoroscopic-based three dimensional volumetric data and previously acquired CT volumetric data in the proximity of the target area; correcting three dimensional relation of the medical device to the target area; or transforming three dimensional positions of features in the fluoroscopic video from fluoroscope coordinates into a navigation system coordinates for the target area. construct, from the fluoroscopic video and the pose determined for each frame of the fluoroscopic video, fluoroscopic-based three dimensional volumetric data of the target area; and utilize the fluoroscopic-based three dimensional volumetric data for at least one of: locally registering between the fluoroscopic-based three dimensional volumetric data and previously acquired CT volumetric data in the proximity of the target area; correcting three dimensional relation of the medical device to the target area; or transforming three dimensional positions of features in the fluoroscopic video from fluoroscope coordinates into a navigation system coordinates for the target area. locally registering between the fluoroscopic-based three dimensional volumetric data and previously acquired CT volumetric data in the proximity of the target area; correcting three dimensional relation of the medical device to the target area; or transforming three dimensional positions of features in the fluoroscopic video from fluoroscope coordinates into a navigation system coordinates for the target area.