Vaccine composition, comprising or consisting of: a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a cationic or polycationic peptide or protein as a complexing agent; b) a nucleic acid sequence encoding an antigen, wherein the nucleic acid is an RNA; and c) a polymeric carrier molecule for combined packaging the adjuvant component and the RNA encoding the antigen, wherein the carrier molecule for combined packaging of the adjuvant component and the RNA encoding the antigen is a polymeric carrier molecule according to generic formula: L-P 1 -S-[S-P 2 -S] n -S-P 3 -L wherein P 1 and P 3 are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P 1 and P 3 exhibiting at least one -SH-moiety, capable to form a disulfide linkage upon condensation with component P 2, the linear or branched hydrophilic polymer chain being selected from polyethylene glycol, wherein the hydrophilic polymer chain exhibits a molecular weight of 1 kDa to 100 kDa, P 2 is a cationic or polycationic peptide or protein, having a length of 3 to 100 amino acids, or is a cationic or polycationic polymer, having a molecular weight of 0.5 kDa to 30 kDa, each P 2 exhibiting at least two -SH-moieties, capable to form a disulfide linkage upon condensation with further components P 2 or component(s) P 1 and/or P 3; -S-S- is a (reversible) disulfide bond; L is an optional ligand, which may be present or not, and may be selected independently from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence, an antibody, a cell penetrating peptide, TAT, KALA, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of 1 to 50. a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a cationic or polycationic peptide or protein as a complexing agent; b) a nucleic acid sequence encoding an antigen, wherein the nucleic acid is an RNA; and c) a polymeric carrier molecule for combined packaging the adjuvant component and the RNA encoding the antigen, wherein the carrier molecule for combined packaging of the adjuvant component and the RNA encoding the antigen is a polymeric carrier molecule according to generic formula: L-P 1 -S-[S-P 2 -S] n -S-P 3 -L wherein P 1 and P 3 are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P 1 and P 3 exhibiting at least one -SH-moiety, capable to form a disulfide linkage upon condensation with component P 2, the linear or branched hydrophilic polymer chain being selected from polyethylene glycol, wherein the hydrophilic polymer chain exhibits a molecular weight of 1 kDa to 100 kDa, P 2 is a cationic or polycationic peptide or protein, having a length of 3 to 100 amino acids, or is a cationic or polycationic polymer, having a molecular weight of 0.5 kDa to 30 kDa, each P 2 exhibiting at least two -SH-moieties, capable to form a disulfide linkage upon condensation with further components P 2 or component(s) P 1 and/or P 3; -S-S- is a (reversible) disulfide bond; L is an optional ligand, which may be present or not, and may be selected independently from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence, an antibody, a cell penetrating peptide, TAT, KALA, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of 1 to 50. P 1 and P 3 are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P 1 and P 3 exhibiting at least one -SH-moiety, capable to form a disulfide linkage upon condensation with component P 2, the linear or branched hydrophilic polymer chain being selected from polyethylene glycol, wherein the hydrophilic polymer chain exhibits a molecular weight of 1 kDa to 100 kDa, P 2 is a cationic or polycationic peptide or protein, having a length of 3 to 100 amino acids, or is a cationic or polycationic polymer, having a molecular weight of 0.5 kDa to 30 kDa, each P 2 exhibiting at least two -SH-moieties, capable to form a disulfide linkage upon condensation with further components P 2 or component(s) P 1 and/or P 3; -S-S- is a (reversible) disulfide bond; L is an optional ligand, which may be present or not, and may be selected independently from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence, an antibody, a cell penetrating peptide, TAT, KALA, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of 1 to 50.