A compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein: each n is independently 1 or 2; each R 1 is independently selected from hydrogen, cycloalkyl and -(C 1 -C 4 alkylene)-R 4, wherein each R 4 is independently selected from hydrogen, aryl, and cycloalkyl, wherein at least one R 1 is other than hydrogen; and each R 2 is hydrogen; or R 1 and R 2 are taken together to the carbon atom to which they are commonly bound to form a cycloalkyl; each R 6 is independently -(C 1 -C 4 alkylene)-R 9, wherein each R 9 is independently selected from hydrogen, aryl, heteroaryl and cycloalkyl; wherein any aryl, heteroaryl or cycloalkyl portion of R 6 is optionally substituted with up to two substituents independently selected from halo, CF 3, OH, C 1 -C 4 alkoxy, C 1 -C 4 alkenyloxy, phenyl, phenyloxy, and phenylmethyloxy; and wherein one -CH 2 - in the -(C 1 -C 4 alkylene)- portion of R 6 is optionally replaced with -O-; each R 7 is independently selected from hydrogen and methyl; each R 8 is independently selected from methyl and ethyl; each X is independently selected from: each Z is wherein each represents a point of attachment to the compound; and each Y is selected from: and wherein: represents a point of attachment to a -C=O portion of the compound; represents a point of attachment to a -NH portion of the compound; represents a first point of attachment to Z; represents a second point of attachment to Z; and A is selected from -C R 3 or or a tautomeric form of any of the foregoing, wherein: R 3 is OH, -O-(C1-C4 alkyl), NHCN, NHSO 2 R 10, NHOR 11 or N(R 12)(R 13); R 10 and R 11 are selected from -C 1 -C 4 alkyl, cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, any of which are optionally substituted, and hydrogen; each of R 12 and R 13 are independently selected from hydrogen, -C 1 -C 4 alkyl, -(C 1 -C 4 alkylene)-NH-(C 1 -C 4 alkyl), -(C 1 -C 4 alkylene)-O-(C 1 -C 4 alkyl) and -(C 1 -C 4 alkylene)-O-(C 1 -C 4 hydroxyalkyl), or R 12 and R 13 are taken together with the nitrogen atom to which they are commonly bound to form a saturated heterocyclyl optionally comprising one additional heteroatom selected from N, O and S, and wherein the saturated heterocycle is optionally substituted with methyl. each n is independently 1 or 2; each R 1 is independently selected from hydrogen, cycloalkyl and -(C 1 -C 4 alkylene)-R 4, wherein each R 4 is independently selected from hydrogen, aryl, and cycloalkyl, wherein at least one R 1 is other than hydrogen; and each R 2 is hydrogen; or R 1 and R 2 are taken together to the carbon atom to which they are commonly bound to form a cycloalkyl; each R 6 is independently -(C 1 -C 4 alkylene)-R 9, wherein each R 9 is independently selected from hydrogen, aryl, heteroaryl and cycloalkyl; wherein any aryl, heteroaryl or cycloalkyl portion of R 6 is optionally substituted with up to two substituents independently selected from halo, CF 3, OH, C 1 -C 4 alkoxy, C 1 -C 4 alkenyloxy, phenyl, phenyloxy, and phenylmethyloxy; and wherein one -CH 2 - in the -(C 1 -C 4 alkylene)- portion of R 6 is optionally replaced with -O-; each R 7 is independently selected from hydrogen and methyl; each R 8 is independently selected from methyl and ethyl; each X is independently selected from: each Z is wherein each represents a point of attachment to the compound; and each Y is selected from: and wherein: represents a point of attachment to a -C=O portion of the compound; represents a point of attachment to a -NH portion of the compound; represents a first point of attachment to Z; represents a second point of attachment to Z; and represents a point of attachment to a -C=O portion of the compound; represents a point of attachment to a -NH portion of the compound; represents a first point of attachment to Z; represents a second point of attachment to Z; and R 3 is OH, -O-(C1-C4 alkyl), NHCN, NHSO 2 R 10, NHOR 11 or N(R 12)(R 13); R 10 and R 11 are selected from -C 1 -C 4 alkyl, cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, any of which are optionally substituted, and hydrogen; each of R 12 and R 13 are independently selected from hydrogen, -C 1 -C 4 alkyl, -(C 1 -C 4 alkylene)-NH-(C 1 -C 4 alkyl), -(C 1 -C 4 alkylene)-O-(C 1 -C 4 alkyl) and -(C 1 -C 4 alkylene)-O-(C 1 -C 4 hydroxyalkyl), or R 12 and R 13 are taken together with the nitrogen atom to which they are commonly bound to form a saturated heterocyclyl optionally comprising one additional heteroatom selected from N, O and S, and wherein the saturated heterocycle is optionally substituted with methyl.