A system for controlled manufacturing of microbubbles, comprising: a microbubble generation unit having a first inlet (2, 2') for receiving a continuous phase fluid, a second inlet for receiving a dispersed phase fluid, and a bubble formation channel in which microbubbles are generated using the received dispersed phase fluid and the received continuous phase fluid; characterized in that the system further comprises: a liquid pressurization unit having an inlet for receiving a first pressure regulated gaseous medium from a source of said first pressure regulated gaseous medium and being configured for outputting a flow of a pressurized liquid to the first inlet (2, 2') of the microbubble generation unit in dependence of a flow and/or pressure of the received first pressure regulated gaseous medium, wherein the second inlet the microbubble generation unit is connected to a source of a second pressure regulated gaseous medium; a first release valve unit arranged in between the source of the first pressure regulated gaseous medium and the inlet of the liquid pressurization unit and being configured for releasing the first pressure regulated gaseous medium; a second release valve unit arranged in between the source of the the second pressure regulated gaseous medium and the second inlet of the microbubble generation unit and being configured for releasing the second pressure regulated gaseous medium; and a control unit for controlling the first and second release valves in dependence of a comparison between a pressure of the first pressure regulated gaseous medium and a first pressure setting and between a pressure of the second pressure regulated gaseous medium and a second pressure setting, respectively. a microbubble generation unit having a first inlet (2, 2') for receiving a continuous phase fluid, a second inlet for receiving a dispersed phase fluid, and a bubble formation channel in which microbubbles are generated using the received dispersed phase fluid and the received continuous phase fluid; characterized in that the system further comprises: a liquid pressurization unit having an inlet for receiving a first pressure regulated gaseous medium from a source of said first pressure regulated gaseous medium and being configured for outputting a flow of a pressurized liquid to the first inlet (2, 2') of the microbubble generation unit in dependence of a flow and/or pressure of the received first pressure regulated gaseous medium, wherein the second inlet the microbubble generation unit is connected to a source of a second pressure regulated gaseous medium; a first release valve unit arranged in between the source of the first pressure regulated gaseous medium and the inlet of the liquid pressurization unit and being configured for releasing the first pressure regulated gaseous medium; a second release valve unit arranged in between the source of the the second pressure regulated gaseous medium and the second inlet of the microbubble generation unit and being configured for releasing the second pressure regulated gaseous medium; and a control unit for controlling the first and second release valves in dependence of a comparison between a pressure of the first pressure regulated gaseous medium and a first pressure setting and between a pressure of the second pressure regulated gaseous medium and a second pressure setting, respectively. a liquid pressurization unit having an inlet for receiving a first pressure regulated gaseous medium from a source of said first pressure regulated gaseous medium and being configured for outputting a flow of a pressurized liquid to the first inlet (2, 2') of the microbubble generation unit in dependence of a flow and/or pressure of the received first pressure regulated gaseous medium, wherein the second inlet the microbubble generation unit is connected to a source of a second pressure regulated gaseous medium; a first release valve unit arranged in between the source of the first pressure regulated gaseous medium and the inlet of the liquid pressurization unit and being configured for releasing the first pressure regulated gaseous medium; a second release valve unit arranged in between the source of the the second pressure regulated gaseous medium and the second inlet of the microbubble generation unit and being configured for releasing the second pressure regulated gaseous medium; and a control unit for controlling the first and second release valves in dependence of a comparison between a pressure of the first pressure regulated gaseous medium and a first pressure setting and between a pressure of the second pressure regulated gaseous medium and a second pressure setting, respectively.