mhurhangee/ep-ind-claims huggingface dataset:
A CTLA4 mutant molecule comprising an extracellular domain of CTLA4 as shown in SEQ ID NO:8 beginning with alanine at position 26 or methionine at position 27 and ending with aspartic acid at position 150, wherein in the extracellular domain an alanine at position 55 is substituted with a tyrosine, and a leucine at position 130 is substituted with a glutamic acid, for use in treating an immune disorder associated with graft transplantation, wherein the treatment comprises an early phase regimen and an maintenance phase regimen and wherein (i) the early phase regimen ranges from the first 3 to 6 months post-transplantation and comprises administration of the CTLA4 mutant molecule to a subject on day 1, week 2 visit, week 4 visit and then monthly through month 3 visit at a dosage of 10 mg/kg weight of the subject, and (ii) the maintenance phase regimen begins after the early phase regimen ends and involves administration that is not more frequent than monthly of an effective dose of the CTLA4 mutant molecule to a subject so as to provide for serum trough concentration of the CTLA4 mutant molecule between about 0.2μg/mL and about 3μg/mL during the maintenance phase regimen.
Mechanism for adjusting an average speed in a timepiece movement, comprising an escapement wheel and a mechanical oscillator, this mechanical oscillator comprising a balance and a plurality of resiliently flexible blades (23a, 23b), which are resiliently flexible in an oscillation plane (P 4), and which support and return the balance in such a way that this balance oscillates at an angle in the oscillation plane (P 4), characterized in that it includes a pallet fork comprising two rigid pallets (13, 14) which are rigidly connected to the balance and are arranged to co-operate alternately with a toothing of the escapement wheel when the balance oscillates at an angle.
A valve for sealing and selectively opening a flow path from a water-filled inlet to a dry outlet, the valve comprising: (a) a valve body having a valve opening surrounded by a first annular valve seat region, and having a second annular valve seat region surrounding said first annular valve seat region, said valve body including at least one drainage channel in fluid connection with a space between said first and second annular valve seat regions (110, 120), said drainage channel providing a fluid drainage path to outside said valve body; and (b) a plug displaceable between an open state and a closed state for closing said valve opening, said plug having a first annular seal deployed for sealing against said first annular valve seat region and a second annular seal deployed for sealing against said second annular valve seat region, characterized in that said plug is integrated with a flexible diaphragm, the valve further comprising a cover cooperating with said diaphragm to define a control chamber between said diaphragm and said cover, and wherein said plug includes a continuous peripheral section of elastomeric material extending around the plug and forming a continuous bridge between an upper peripheral portion of said plug and said second annular seal such that a pressure difference between said control chamber and said drainage channel effects a shear deformation of said peripheral section, thereby varying a closing force of said second annular seal against said second annular valve seat region, and wherein said second annular flexible seal and said peripheral section of said plug are configured such that, during displacement of said plug from said open state towards said closed state, said second annular seal closes against said second annular valve seat region prior to contact between said first annular seal and said first annular valve seat region, said second annular seal being elastically deformed so as to be pressed into contact with said second annular valve seat region when said plug reaches said closed state. (a) a valve body having a valve opening surrounded by a first annular valve seat region, and having a second annular valve seat region surrounding said first annular valve seat region, said valve body including at least one drainage channel in fluid connection with a space between said first and second annular valve seat regions (110, 120), said drainage channel providing a fluid drainage path to outside said valve body; and (b) a plug displaceable between an open state and a closed state for closing said valve opening, said plug having a first annular seal deployed for sealing against said first annular valve seat region and a second annular seal deployed for sealing against said second annular valve seat region,
A solid dosage form comprising: a matrix core which comprises a hydrophobic material and a water-soluble pharmaceutical agent; and a modified release coating surrounding the matrix core, wherein the modified release coating comprises a hydrophobic polymer and a hydrophilic pore-forming agent; an overcoating surrounding the modified release coating, wherein the overcoating comprises a pharmaceutical agent and a water-soluble polymer and wherein the overcoating is present at a weight gain from 2 to 25 wt.% based on total weight of the solid dosage form; wherein the solid dosage form is capable of releasing the pharmaceutical agent at a zero order release rate for a period of at least four hours after administration to a subject. a matrix core which comprises a hydrophobic material and a water-soluble pharmaceutical agent; and a modified release coating surrounding the matrix core, wherein the modified release coating comprises a hydrophobic polymer and a hydrophilic pore-forming agent; an overcoating surrounding the modified release coating, wherein the overcoating comprises a pharmaceutical agent and a water-soluble polymer and wherein the overcoating is present at a weight gain from 2 to 25 wt.% based on total weight of the solid dosage form; wherein the solid dosage form is capable of releasing the pharmaceutical agent at a zero order release rate for a period of at least four hours after administration to a subject.
A phosphorus-containing compound represented by following general formula: wherein m represents a number of 1 to 10; R 1 is an alkyl group having 1 to 5 carbon atoms, R 2 is an alkyl group having 1 to 5 carbon atoms; R 3 represents an aromatic group represented by any one of formulae: X represents an oxygen atom; and Y represents an oxygen atom.
Pressure vessel consisting of an inner container made of plastic with front sides (3, 4) and on the end faces (3, 4) arranged collars and from an outer jacket made from a fiber-reinforced reinforcement, wherein between the inner container and the outer jacket on the front sides (3, 4) Connection pieces (6.7) and deepening for connecting pieces (6.7) are arranged, which are adapted to the curvature of the front side (3, 4) and arched flanges are provided and with the front side (3, 4) of the inner container has an inner thread with an inside into the Inner container-directed collar with an inner bore and one, the external thread of a central part of the arched flange receiving internal threads are arranged, characterized in that that the inner container with an in the melted outer skin of the Inner container incorporated fabric is provided and in the arched flanges of the connecting pieces (6,7) bores are, via which a form-fitting connection by welding the Inner container with the arched flanges by means of drop-forming Burning plastic made and sealed with silicone and glue is.
A method for preparing a polycarbonate comprising the steps of: 1) adding an antioxidant, and a hydrolysis-resistant agent having an epoxy-fused aliphatic ring to a polycarbonate polymerization solution; and 2) removing a solvent in the polycarbonate polymerization solution by using steam, wherein the antioxidant comprises a phosphite-based antioxidant, and a hindered phenol-based antioxidant. 1) adding an antioxidant, and a hydrolysis-resistant agent having an epoxy-fused aliphatic ring to a polycarbonate polymerization solution; and 2) removing a solvent in the polycarbonate polymerization solution by using steam,
A method of wireless communication in a simultaneous voice and data communication, comprising: detecting, in a wireless terminal, a power limited mode based on a condition of the wireless terminal, wherein the wireless terminal enters the power limited mode once current transmission power exceeds a threshold; and suspending, based on the detecting, transmission of at least a portion of information of at least one uplink channel at the wireless terminal, for a duration of the detected power limited mode. detecting, in a wireless terminal, a power limited mode based on a condition of the wireless terminal, wherein the wireless terminal enters the power limited mode once current transmission power exceeds a threshold; and suspending, based on the detecting, transmission of at least a portion of information of at least one uplink channel at the wireless terminal, for a duration of the detected power limited mode.
A composition comprising: (a) carbohydrate; (b) lipid, comprising from about 0.25% to about 2.5 % lecithin by weight of total lipid; (c) from about 0.5% to about 10% of hydrolyzed casein protein by weight of total protein, wherein the hydrolyzed casein protein has a degree of hydrolysis of between about 8% and about 90%; and (d) from about 90% to about 99.5% intact protein by weight of total protein; wherein the composition is a nutritional powder. (a) carbohydrate; (b) lipid, comprising from about 0.25% to about 2.5 % lecithin by weight of total lipid; (c) from about 0.5% to about 10% of hydrolyzed casein protein by weight of total protein, wherein the hydrolyzed casein protein has a degree of hydrolysis of between about 8% and about 90%; and (d) from about 90% to about 99.5% intact protein by weight of total protein;
A negative electrode for a nonaqueous electrolyte secondary battery comprising: a current collector; and a mixture layer formed on the current collector and having an active material and a binder, wherein the binder comprises an intermolecular chain network formed therein, in which crosslinking by irreversible bonding and crosslinking by reversible bonding are mixed, characterized in that: the binder includes a main binder and an auxiliary binder, the main binder includes sodium polyacrylate and the auxiliary binder includes acrylic acid-maleic acid copolymer, wherein the irreversible bonding given to the main binder is such that an aziridine compound is used as a crosslinking agent and the reversible bonding given to the main binder and the auxiliary binder is a metal ion bond by calcium ions. a current collector; and a mixture layer formed on the current collector and having an active material and a binder, wherein the binder comprises an intermolecular chain network formed therein, in which crosslinking by irreversible bonding and crosslinking by reversible bonding are mixed, characterized in that: the binder includes a main binder and an auxiliary binder, the main binder includes sodium polyacrylate and the auxiliary binder includes acrylic acid-maleic acid copolymer, wherein the irreversible bonding given to the main binder is such that an aziridine compound is used as a crosslinking agent and the reversible bonding given to the main binder and the auxiliary binder is a metal ion bond by calcium ions.
A channel monitoring indication method, applied to a terminal and comprising: monitoring a first physical downlink control channel PDCCH; and if downlink control information DCI not used for scheduling is received on the first PDCCH, wherein the DCI not used for scheduling is used to indicate whether the terminal is to monitor a second PDCCH, determining, based on the DCI not used for scheduling, whether to monitor a second PDCCH; characterized in that after the step of monitoring a first physical downlink control channel PDCCH, the method further comprises: if the DCI not used for scheduling is received on the first PDCCH, feeding back acknowledgement ACK information. monitoring a first physical downlink control channel PDCCH; and if downlink control information DCI not used for scheduling is received on the first PDCCH, wherein the DCI not used for scheduling is used to indicate whether the terminal is to monitor a second PDCCH, determining, based on the DCI not used for scheduling, whether to monitor a second PDCCH; characterized in that after the step of monitoring a first physical downlink control channel PDCCH, the method further comprises: if the DCI not used for scheduling is received on the first PDCCH, feeding back acknowledgement ACK information.
An outdoor unit (2, 202) for a refrigeration cycle apparatus comprising: a fan; a bellmouth that covers a periphery of the fan; a casing that internally houses the fan and the bellmouth, so that airflow faces upward, and that has a top end edge having a flat shape (84, 89, 94, 99); and a diffuser surface (91, 91a, 96, 291) located below the top end edge of the casing but above a top end of the bellmouth and on the outer side relative to the top end of the bellmouth in plan view, and the diffuser surface (91, 91a, 96, 291) being inclined so as to separate outward away from a rotation axis of the fan, with respect to a direction of the rotation axis heading upward, characterized in that the casing has a plurality of side surfaces (93, 98, 80, 85, 293) that cover the sides of the bellmouth; and at least one of the side surfaces (80, 85) has a recessed shape (81, 86) toward the bellmouth, so that a gap with the top end edge of the bellmouth is reduced. a fan; a bellmouth that covers a periphery of the fan; a casing that internally houses the fan and the bellmouth, so that airflow faces upward, and that has a top end edge having a flat shape (84, 89, 94, 99); and a diffuser surface (91, 91a, 96, 291) located below the top end edge of the casing but above a top end of the bellmouth and on the outer side relative to the top end of the bellmouth in plan view, and the diffuser surface (91, 91a, 96, 291) being inclined so as to separate outward away from a rotation axis of the fan, with respect to a direction of the rotation axis heading upward, characterized in that the casing has a plurality of side surfaces (93, 98, 80, 85, 293) that cover the sides of the bellmouth; and at least one of the side surfaces (80, 85) has a recessed shape (81, 86) toward the bellmouth, so that a gap with the top end edge of the bellmouth is reduced.
A reducing fibre optic cable tube connector, the connector comprising a connector body made of a plastic, the body defining a through bore and having a connector at either end for connection to a respective tube; the body having a wide portion terminating at a wide end and a narrow portion terminating at a narrow end, the wide end being dimensioned to receive a first tube of a first diameter and the narrow end being dimensioned to receive a second tube of a second diameter smaller than the first diameter, the two portions meeting at a central region of the body; the wide portion of the body comprising a wide outer body and an annular wide inner sleeve extending from the central region towards the wide end, the outer wall of the wide inner sleeve being generally spaced from an inner wall of the wide outer body to define a first air gap, the distal end of the first tube being receivable within the wide inner sleeve; the narrow portion of the body comprising a narrow outer body and an annular narrow inner sleeve extending from the central region towards the narrow end, the outer wall of the narrow inner sleeve being generally spaced from an inner wall of the narrow outer body to define a second air gap, the distal end of the second tube being receivable within the narrow inner sleeve; characterized in that at the central region the annular narrow inner sleeve extends towards the annular wide inner sleeve such that the first and second air gaps are spaced in an axial sense by less than 1mm. the body having a wide portion terminating at a wide end and a narrow portion terminating at a narrow end, the wide end being dimensioned to receive a first tube of a first diameter and the narrow end being dimensioned to receive a second tube of a second diameter smaller than the first diameter, the two portions meeting at a central region of the body; the wide portion of the body comprising a wide outer body and an annular wide inner sleeve extending from the central region towards the wide end, the outer wall of the wide inner sleeve being generally spaced from an inner wall of the wide outer body to define a first air gap, the distal end of the first tube being receivable within the wide inner sleeve; the narrow portion of the body comprising a narrow outer body and an annular narrow inner sleeve extending from the central region towards the narrow end, the outer wall of the narrow inner sleeve being generally spaced from an inner wall of the narrow outer body to define a second air gap, the distal end of the second tube being receivable within the narrow inner sleeve; characterized in that at the central region the annular narrow inner sleeve extends towards the annular wide inner sleeve such that the first and second air gaps are spaced in an axial sense by less than 1mm.
Use of a composition comprising, as an active ingredient, an N-2-(pyridyl)ethylcarboxamide derivative represented by the formula: wherein, Ar is a substituted phenyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo (C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; a substituted pyridyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; or a substituted pyrazolyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; X may be the same or different, and is a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkoxy group or a halo(C 1 -C 6) alkoxy group, and n is the integer 0 to 4, or a salt thereof, as a nematocide. Ar is a substituted phenyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo (C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; a substituted pyridyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; or a substituted pyrazolyl group having one or more, the same or different substituents selected from a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkylthio group, a halo(C 1 -C 6) alkylthio group, a (C 1 -C 6) alkoxy group and a halo(C 1 -C 6) alkoxy group; X may be the same or different, and is a halogen atom, a (C 1 -C 6) alkyl group, a halo(C 1 -C 6) alkyl group, a (C 1 -C 6) alkoxy group or a halo(C 1 -C 6) alkoxy group, and n is the integer 0 to 4, or a salt thereof, as a nematocide.
A flexible mat-like substrate having a length of optical fiber mounted thereon or therein for use in an optical fiber sensor system, the length of the optical fiber being arranged in a deployment pattern on or in said substrate so as to provide a sensing area comprising said deployment pattern of increased spatial sensing resolution than the native sensing resolution otherwise provided by the fiber to the optical fiber sensing system, characterised in that the mat is provided with one or more areas of increased hardness with respect to the remainder of the substrate, the arrangement being such that the fiber lays over the areas of increased hardness.
A shock-absorbing member comprising: a tubular main body portion; a bent portion that is formed continuous with the main body portion; and a flange provided at a proximal end of the main body portion via the bent portion, wherein the main body portion is caused to undergo eversion deformation by a shock power acting on a distal end of the main body portion so that a shock energy is absorbed, and wherein the main body portion has a regular polygonal cross-section orthogonal to an axial direction, and has a tapered shape that an area of the cross-section orthogonal to the axial direction decreases toward the distal end, characterized in that, the bent portion has a U-shape, and completely extends around the whole perimeter of a proximal end of the main body portion. a tubular main body portion; a bent portion that is formed continuous with the main body portion; and a flange provided at a proximal end of the main body portion via the bent portion, wherein the main body portion is caused to undergo eversion deformation by a shock power acting on a distal end of the main body portion so that a shock energy is absorbed, and wherein the main body portion has a regular polygonal cross-section orthogonal to an axial direction, and has a tapered shape that an area of the cross-section orthogonal to the axial direction decreases toward the distal end, characterized in that, the bent portion has a U-shape, and completely extends around the whole perimeter of a proximal end of the main body portion.
A method of determining an amount of glycated hemoglobin comprising: hemolyzing whole blood using a non-ionic surfactant; degrading glycated hemoglobin in the hemolyzed whole blood selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining the redox reaction to determine an amount of the glycated hemoglobin; wherein the protease is a metalloproteinase capable of selectively degrading the glycated hemoglobin. hemolyzing whole blood using a non-ionic surfactant; degrading glycated hemoglobin in the hemolyzed whole blood selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining the redox reaction to determine an amount of the glycated hemoglobin; wherein the protease is a metalloproteinase capable of selectively degrading the glycated hemoglobin.
Composition, especially a cosmetic composition, comprising: - (i) one or more alkoxysilanes, and - (ii) one or more starches modified with an acid or an acid derivative. - (i) one or more alkoxysilanes, and - (ii) one or more starches modified with an acid or an acid derivative.