mhurhangee/ep-ind-claims huggingface dataset:
A modified effector cell expressing a chimeric receptor comprising a disialoganglioside class-II recognizing immunoglobulin and an intracytoplasmic portion comprising human co-stimulatory 4-1BB, characterized in that said immunoglobulin comprises an IgM derived portion including a single chain variable fragment scFv and said co-stimulatory 4-1BB, and in that, said chimeric receptor comprises said intracytoplasmic portion and an extra-cytoplasmic portion wherein said extra-cytoplasmic portion is the anti-GD2 MoAb IGM clone 126.
A fiber comprising a bioactive agent and a biodegradable poly(esteramide) copolymer according to structural formula, wherein - m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; - m+p+q=1, whereby m or p could be 0; - n is from 5 to 300; wherein units of m (if present), units of p (if present), units of a, and units of b are all randomly distributed throughout the copolymer; - R 1 is (C 2 -C 20) alkylene; - R 3 and R 4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, -CH 3, -CH 2 OH, -CH CH 3, -CH 2 -CO-NH 2, -(CH 2) 2 -CO-NH 2, -CH 2 COOH, -CH 2 CH 2 COOH, -CH(CH 3) 2, CH 3 -CH 2 -CH(CH 3)-, -CH 2 -C 6 H 5, -(CH 2) 4 -NH 2, -(CH 2) 4 -NH 3 +, -(CH 2) 3 NHC(=NH 2 +)NH 2, (CH 3) 2 CH-CH 2 -, -(CH 2)SH, -(CH 2) 2 S(CH 3), - R 5 is (C 2 -C 20)alkylene; - R 6 is according to structural formula; - R 7 is (C 6 -C 10)aryl(C 1 -C 6)alkylene; - R 8 is -(CH 2) 4 -; whereby a is at least 0.05, b is at least 0.05 and a+b=1. - m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; - m+p+q=1, whereby m or p could be 0; - n is from 5 to 300; wherein units of m (if present), units of p (if present), units of a, and units of b are all randomly distributed throughout the copolymer; - R 1 is (C 2 -C 20) alkylene; - R 3 and R 4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, -CH 3, -CH 2 OH, -CH CH 3, -CH 2 -CO-NH 2, -(CH 2) 2 -CO-NH 2, -CH 2 COOH, -CH 2 CH 2 COOH, -CH(CH 3) 2, CH 3 -CH 2 -CH(CH 3)-, -CH 2 -C 6 H 5, -(CH 2) 4 -NH 2, -(CH 2) 4 -NH 3 +, -(CH 2) 3 NHC(=NH 2 +)NH 2, (CH 3) 2 CH-CH 2 -, -(CH 2)SH, -(CH 2) 2 S(CH 3), - R 5 is (C 2 -C 20)alkylene; - R 6 is according to structural formula; - R 7 is (C 6 -C 10)aryl(C 1 -C 6)alkylene; - R 8 is -(CH 2) 4 -; - R 1 is (C 2 -C 20) alkylene; - R 3 and R 4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, -CH 3, -CH 2 OH, -CH CH 3, -CH 2 -CO-NH 2, -(CH 2) 2 -CO-NH 2, -CH 2 COOH, -CH 2 CH 2 COOH, -CH(CH 3) 2, CH 3 -CH 2 -CH(CH 3)-, -CH 2 -C 6 H 5, -(CH 2) 4 -NH 2, -(CH 2) 4 -NH 3 +, -(CH 2) 3 NHC(=NH 2 +)NH 2, (CH 3) 2 CH-CH 2 -, -(CH 2)SH, -(CH 2) 2 S(CH 3), - R 5 is (C 2 -C 20)alkylene; - R 6 is according to structural formula; - R 7 is (C 6 -C 10)aryl(C 1 -C 6)alkylene; - R 8 is -(CH 2) 4 -; whereby a is at least 0.05, b is at least 0.05 and a+b=1.
An apparatus comprising: (a) a body; (b) a cannula extending distally from the body, wherein the cannula defines a longitudinal axis; (c) a hollow needle, wherein the needle is pre-bent such that needle is resiliently biased to a desired angle, wherein the needle is slidable relative to the cannula and constrained to follow a substantially straight path within the cannula; and (d) an actuation assembly, wherein the actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula such that the needle is advanced distally relative to the cannula in a position that is angled relative to the cannula; characterized in that: the apparatus is for delivering therapeutic agent to an eye; and the cannula is sized and configured to be insertable between a choroid and a sclera of a patient's eye, and the cannula has a generally rectangular cross-section. (a) a body; (b) a cannula extending distally from the body, wherein the cannula defines a longitudinal axis; (c) a hollow needle, wherein the needle is pre-bent such that needle is resiliently biased to a desired angle, wherein the needle is slidable relative to the cannula and constrained to follow a substantially straight path within the cannula; and (d) an actuation assembly, wherein the actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula such that the needle is advanced distally relative to the cannula in a position that is angled relative to the cannula; the apparatus is for delivering therapeutic agent to an eye; and the cannula is sized and configured to be insertable between a choroid and a sclera of a patient's eye, and the cannula has a generally rectangular cross-section.
A system for providing visual indication of temperature change during a surgical process, comprising: a surgical element comprising at least one tip; and a reversible thermochromic element partially covering the surgical element, wherein the reversible thermochromic element is capable of changing in color based on a determined temperature of the at least one tip, wherein the surgical element is a phacoemulsification handpiece, characterized in that the reversible thermochromic element is a paint or ink layer applied to the surface of the tip. a surgical element comprising at least one tip; and a reversible thermochromic element partially covering the surgical element, wherein the reversible thermochromic element is capable of changing in color based on a determined temperature of the at least one tip, wherein the surgical element is a phacoemulsification handpiece, characterized in that the reversible thermochromic element is a paint or ink layer applied to the surface of the tip.
Apparatus for ultrasonic testing of a component with a surface, which comprises an underside that can be placed onto the surface, at least one ultrasonic test head, a guide slide to which the test head is fastened, and a guide unit, wherein: - the guide unit comprises an opening which is bounded by an upper guide rail having a first guide element and a lower guide rail having a second guide element; - the guide slide is arranged inside the opening and is configured such that it can be moved continuously in a translation direction along the guide rails (13, 14); - the guide rails (13, 14) are arched with respect to the underside and the guide elements (15, 16) are curved, wherein the first guide element trails the second guide element in the translation direction of the guide slide; - the guide elements (15, 16) engage in corresponding recesses on the guide slide and achieve the respective squint angle of the test head with respect to the underside and the surface by virtue of the guide slide rotating about an axis perpendicular to the translation direction over the course of the translational movement; and - one guide rail is recessed to a greater extent than the other and defines the squint angle of the test head by virtue of a position difference with respect to the other guide rail, wherein the squint angle of the test head is varied continuously at the same time as the translational movement of the test head. - the guide unit comprises an opening which is bounded by an upper guide rail having a first guide element and a lower guide rail having a second guide element; - the guide slide is arranged inside the opening and is configured such that it can be moved continuously in a translation direction along the guide rails (13, 14); - the guide rails (13, 14) are arched with respect to the underside and the guide elements (15, 16) are curved, wherein the first guide element trails the second guide element in the translation direction of the guide slide; - the guide elements (15, 16) engage in corresponding recesses on the guide slide and achieve the respective squint angle of the test head with respect to the underside and the surface by virtue of the guide slide rotating about an axis perpendicular to the translation direction over the course of the translational movement; and - one guide rail is recessed to a greater extent than the other and defines the squint angle of the test head by virtue of a position difference with respect to the other guide rail, wherein the squint angle of the test head is varied continuously at the same time as the translational movement of the test head.
An endoscopic device, comprising: a clip assembly, comprising a first jaw, a second jaw, a housing having an internal channel, wherein at least a portion of the first and second jaws is disposed within the internal channel, the first and second jaws selectively move along with the internal channel between a fully closed position and a fully opened position, and a release portion, connecting to the first and second jaws, wherein at least a portion of the release portion is proximal from the first and second jaws; and a driving assembly, comprising an outer sheath, an inner tube, movably disposed within the outer sheath, and characterized in that it comprises a driver, movably disposed within the inner tube, and removably received within the release portion, wherein the driver is unbrokenly released from the release portion by a predetermined pull force, wherein the housing and the outer sheath forms a releasable handshake engagement, and the inner tube extending into the housing prevents the handshake engagement from disengaging. a clip assembly, comprising a first jaw, a second jaw, a housing having an internal channel, wherein at least a portion of the first and second jaws is disposed within the internal channel, the first and second jaws selectively move along with the internal channel between a fully closed position and a fully opened position, and a release portion, connecting to the first and second jaws, wherein at least a first jaw, a second jaw, a housing having an internal channel, wherein at least a portion of the first and second jaws is disposed within the internal channel, the first and second jaws selectively move along with the internal channel between a fully closed position and a fully opened position, and a release portion, connecting to the first and second jaws, wherein at least a portion of the release portion is proximal from the first and second jaws; and a driving assembly, comprising an outer sheath, an inner tube, movably disposed within the outer sheath, and characterized in that it comprises a driver, movably disposed within the inner tube, and removably received within the release portion, wherein the driver is unbrokenly released from the release portion by a predetermined pull force, an outer sheath, an inner tube, movably disposed within the outer sheath, and characterized in that it comprises a driver, movably disposed within the inner tube, and removably received within the release portion, wherein the driver is unbrokenly released from the release portion by a predetermined pull force,
A network communication device comprising: a processing unit; memory; at least a first instance of a first virtual meter and a second instance of a second virtual meter stored in the memory and running on the processing unit; and a communication interface through which the first instance of the first virtual meter and the second instance of the second virtual meter respectively receive data from a first remote metrology sensor and a second remote metrology sensor; a first memory space storing data related to the first instance of the first virtual meter; and a second memory space storing data related to the second instance of the second virtual meter; wherein the network communication device is configured such that each instance of a virtual meter includes a plurality of applications; and such that the data in the first memory space is inaccessible by the second virtual meter and the data in the second memory space is inaccessible by the first virtual meter, thereby isolating the first and second virtual meters from each other and enforcing this isolation by establishing a mapping relationship between each virtual meter and respective one or more applications and/or data such that each instance of a virtual meter is prevented from accessing and/or manipulating the data associated with the other virtual meter. a processing unit; memory; at least a first instance of a first virtual meter and a second instance of a second virtual meter stored in the memory and running on the processing unit; and a communication interface through which the first instance of the first virtual meter and the second instance of the second virtual meter respectively receive data from a first remote metrology sensor and a second remote metrology sensor; a first memory space storing data related to the first instance of the first virtual meter; and a second memory space storing data related to the second instance of the second virtual meter; wherein the network communication device is configured such that each instance of a virtual meter includes a plurality of applications; and such that the data in the first memory space is inaccessible by the second virtual meter and the data in the second memory space is inaccessible by the first virtual meter, thereby isolating the first and second virtual meters from each other and enforcing this isolation by establishing a mapping relationship between each virtual meter and respective one or more applications and/or data such that each instance of a virtual meter is prevented from accessing and/or manipulating the data associated with the other virtual meter.
A sensor device for identifying a leak location in an ostomy system, the sensor device comprising: a stoma opening; and an electrically conductive circuitry arranged in pattern around the stoma opening, the electrically conductive circuitry comprising a first electrode and a second electrode spaced from the first electrode, characterized in that the first electrode is subdivided by a plurality of resistors (R1, R2... Ri) spaced along a length of the first electrode, wherein the second electrode extends as a continuous strip of conductive material, and wherein the sensor device is configured to detect electrical resistance in the electrically conductive circuit and identify a location of a leak based on the detected electrical resistance. a stoma opening; and an electrically conductive circuitry arranged in pattern around the stoma opening, the electrically conductive circuitry comprising a first electrode and a second electrode spaced from the first electrode, characterized in that the first electrode is subdivided by a plurality of resistors (R1, R2... Ri) spaced along a length of the first electrode, wherein the second electrode extends as a continuous strip of conductive material, and wherein the sensor device is configured to detect electrical resistance in the electrically conductive circuit and identify a location of a leak based on the detected electrical resistance.
A tire mold comprising an outer mold for forming a tire outside face and an inner mold for forming a tire inside face, a cavity that molds a tire frame member when molten thermoplastic resin material is poured in, formed between the outer mold and the inner mold, and a bead core retaining jig that moves into and retracts from the cavity, wherein the bead core retaining jig includes a plurality of main jigs for fixing a covered bead, the main jigs being provided at the inner mold, wherein a shaped recess portion is provided at each main jig, so that the covered bead is in a state in which movement towards the tire inside direction is restricted, and movement in the tire radial direction is also restricted, and wherein the tire mold is configured so that molten resin can continue to be poured in as the main jigs are retracted.
A method of manufacturing a shim, comprising: inserting a mechanical tool into a shim space defined between two or more components (12,14) with the mechanical tool in a first configuration; the mechanical tool being free of measurement electronics; modifying the mechanical tool, while the mechanical tool is in the shim space, such that the mechanical tool assumes a second configuration to establish a plurality of model points corresponding to a boundary surface of the shim space; removing the mechanical tool from the shim space while maintaining the mechanical tool in the second configuration; thereafter, electronically measuring, with a measurement station distinct from the mechanical tool, positions of the model points relative to a reference plane while the mechanical tool is both disposed outside of the shim space and in the second configuration; generating machining instructions based on the measured positions; and fabricating the shim based on the generated machining instructions. inserting a mechanical tool into a shim space defined between two or more components (12,14) with the mechanical tool in a first configuration; the mechanical tool being free of measurement electronics; modifying the mechanical tool, while the mechanical tool is in the shim space, such that the mechanical tool assumes a second configuration to establish a plurality of model points corresponding to a boundary surface of the shim space; removing the mechanical tool from the shim space while maintaining the mechanical tool in the second configuration; thereafter, electronically measuring, with a measurement station distinct from the mechanical tool, positions of the model points relative to a reference plane while the mechanical tool is both disposed outside of the shim space and in the second configuration; generating machining instructions based on the measured positions; and fabricating the shim based on the generated machining instructions.
A cuff (10, 20, 30) for use with an inflation-based non-invasive blood pressure, NIBP, measurement apparatus, the cuff (10, 20, 30) comprising: an inlet (12, 22, 32) configured to be coupled to an outlet of the inflation-based NIBP measurement apparatus to receive a flow of fluid; a bladder (14, 24, 34) coupled to the inlet (12, 22, 32) and inflatable to pressurize a measurement site of a subject by receiving the flow of fluid; and a valve (16, 26, 36) disposed along a flow path between the inlet (12, 22, 32) and the bladder (14, 24, 34) or disposed on the bladder (14, 24, 34), characterized in that the valve (16, 26, 36) is configured to pass part of the flow of fluid received in the bladder (14, 24, 34) to the atmosphere during inflation of the bladder (14, 24, 34) and the valve (16, 26, 36) is sized to have a flow resistance that causes the bladder (14, 24, 34) to inflate at a required flow rate for inflating the cuff (10, 20, 30). an inlet (12, 22, 32) configured to be coupled to an outlet of the inflation-based NIBP measurement apparatus to receive a flow of fluid; a bladder (14, 24, 34) coupled to the inlet (12, 22, 32) and inflatable to pressurize a measurement site of a subject by receiving the flow of fluid; and a valve (16, 26, 36) disposed along a flow path between the inlet (12, 22, 32) and the bladder (14, 24, 34) or disposed on the bladder (14, 24, 34), characterized in that the valve (16, 26, 36) is configured to pass part of the flow of fluid received in the bladder (14, 24, 34) to the atmosphere during inflation of the bladder (14, 24, 34) and the valve (16, 26, 36) is sized to have a flow resistance that causes the bladder (14, 24, 34) to inflate at a required flow rate for inflating the cuff (10, 20, 30).
A communications system comprising two light sources (4,5) one of the light sources being for illumination and the other of the light sources being for generating a communication data carrying signal, a side-emitting fibre light rope into which light emitted from the light sources is coupled, a processor for controlling the other of the light sources, the processor being configured to process communication data from a remote data centre for transmitting along the light rope and means for sending at least one communication data carrying optical signal along the light rope, wherein the light sources (4, 5) and light rope are arranged to provide communication and a source of illumination along the length of the fibre light rope, such that the imposed communication data carrying optical signal is broadcast into regions surrounding the light rope throughout the length of the light rope, and further comprising: a detector for detecting the data carrying signal; wherein the means for sending at least one data carrying optical signal along the light rope are operable to modulate the light from the light source for generating the communication data carrying signal, the modulation representing the communication data carrying signal; and the detector is operable to decode or demodulate the detected signal thereby to determine the communication data. a detector for detecting the data carrying signal; wherein the means for sending at least one data carrying optical signal along the light rope are operable to modulate the light from the light source for generating the communication data carrying signal, the modulation representing the communication data carrying signal; and the detector is operable to decode or demodulate the detected signal thereby to determine the communication data.
A control system for controlling manipulation of a surgical instrument in response to manipulation of a remote surgeon input device at a remote surgeon's console, the surgical instrument being supported by a surgical robot arm, the surgical robot arm comprising a series of links between a base and an attachment for the surgical instrument, the links being interspersed by joints (305a, 305b, 305c, 305d, 305e, 305f, 305g, 305h), the surgical instrument comprising an end effector connected to a distal end of a shaft by an articulated coupling, the articulated coupling comprising one or more joints (204, 207, 211) enabling the end effector to adopt a range of attitudes relative to the distal end of the shaft, the control system configured to: receive a command from an input actuated by a user to straighten the surgical instrument; and in response to the received command, to command driving forces to be applied to joint(s) (204, 207, 211) of the articulated coupling to drive the instrument to adopt a predetermined configuration in which the profile of the end effector is most closely aligned with the profile of the distal end of the shaft, and in response to the received command, command driving forces to be applied to one or more joints (305a, 305b, 305c, 305d, 305e, 305f, 305g, 305h) of the surgical robot arm to drive the surgical robot arm to adopt a predetermined arm configuration. receive a command from an input actuated by a user to straighten the surgical instrument; and in response to the received command, to command driving forces to be applied to joint(s) (204, 207, 211) of the articulated coupling to drive the instrument to adopt a predetermined configuration in which the profile of the end effector is most closely aligned with the profile of the distal end of the shaft, and in response to the received command, command driving forces to be applied to one or more joints (305a, 305b, 305c, 305d, 305e, 305f, 305g, 305h) of the surgical robot arm to drive the surgical robot arm to adopt a predetermined arm configuration.