A compound of the formula: R1 and R2 are independently hydrogen, Cl, Br, F, I, trihaloalkyl, trihaloalkoxy cyano, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, -CORd, -COORd, -CON(Rc)Rd, -N(Rc)Rd, -N(Rc)CORd wherein each Rd is independently a hydrogen, C 1-6 linear or branched alkyl or cycloalkyl, C 1-6 linear or branched alkenyl or heterocyclyl chosen from pyrrole, pyrrolidinyl, pyrazole, imidazole, furan, tetrahydrofuran, oxazole, thiophene, tetrahydrothiophene and thiazole wherein for each ring possessing a sulfur heteroatom the sulfur is -S-, -S - or -S 2 -, or where R1 and R2 together represent -O-CH 2 -O, -O-CH 2 -CH 2 -O- or -CH 2 -CH 2 -CH 2 -, wherein each group is optionally independently substituted with one to three substituents chosen from C 1-4 acyl, C 1-4 alkyl, C 1-4 alkoxy, amino, dialkylamino, cyano, carboxy, carboxamido, Cl, Br, F, I, hydroxyl and phenyl optionally substituted with one to three Cl, Br, F, I,; A is C1-C 7 linear, branched optionally independently substituted with one to three substituents chosen from amino, cyano, carboxy, carboxamido, halogen, hydroxyl, nitro, phenyl, C 1-6 linear or branched alkyl and C 1-6 linear or branched alkoxy; E is -COORe, -SO 3 Re, -CONHRe, -CONHSO 2 Re, -SO 2 NH-CO(Rf), tetrazol-5-yl, 5-oxo-1,2,4-oxadiazol-3-yl, 5-oxo-1,2,4-thiadiazol-3-yl, 5-thioxo-1,2,4-oxadiazol-3-yl, 5-thioxo-1,2,4-thiadiazol-3-yl, 3-oxo-1,2,4-oxadiazol-5-yl, N3,5-dioxo-5-oxadiazolidino, 2-oxo1,3,4-oxadiazol-2-yl, 3-oxol,2,4-triazol-5-yl or 2,dioxo-benzothiadiazin-6-yl, wherein each Re is independently hydrogen, C 1-4 alkyl or phenyl, and Rf is C 1-4 alkyl or aryl; G is C 1-4 linear or branched alkyl optionally substituted with a substituent chosen from hydroxyl, a cyano, C 1-6 linear or branched alkyl and C 1-6 linear or branched alkoxy; M is a methylene group, oxygen, -N(Rb)-, or -S m -, where m is an integer of 0-2; J is an optionally mono- or di-substituted phenyl, naphthyl, benzothienyl, benzopyrrolyl, benzimidazolyl, indolyl; each substituent on said aromatic or heteroaromatic groups is chosen from halogen, hydroxyl, cyano, C 1-4 linear or branched alkyl, C 1-4 linear or branched alkoxy, C 1-6 linear or branched alkylthio, C 1-6 linear or branched alkylsulfonyl, phenylsulfonyl, C 1-6 linear or branched acyl, C 1-6 linear or branched acylamino, trihalomethyl, trihalomethyxy, phenyl, oxo, -COORa, -CON(Rc)Ra, -SO 2 N(Rc)Ra, N(Rc)Ra and phenoxy optionally substituted by one or more halogens; Ra,Rb and Rc are each independently C1-3 alkyl or hydrogen; or the pharmaceutically acceptable salts thereof. R1 and R2 are independently hydrogen, Cl, Br, F, I, trihaloalkyl, trihaloalkoxy cyano, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, -CORd, -COORd, -CON(Rc)Rd, -N(Rc)Rd, -N(Rc)CORd wherein each Rd is independently a hydrogen, C 1-6 linear or branched alkyl or cycloalkyl, C 1-6 linear or branched alkenyl or heterocyclyl chosen from pyrrole, pyrrolidinyl, pyrazole, imidazole, furan, tetrahydrofuran, oxazole, thiophene, tetrahydrothiophene and thiazole wherein for each ring possessing a sulfur heteroatom the sulfur is -S-, -S - or -S 2 -, or where R1 and R2 together represent -O-CH 2 -O, -O-CH 2 -CH 2 -O- or -CH 2 -CH 2 -CH 2 -, wherein each group is optionally independently substituted with one to three substituents chosen from C 1-4 acyl, C 1-4 alkyl, C 1-4 alkoxy, amino, dialkylamino, cyano, carboxy, carboxamido, Cl, Br, F, I, hydroxyl and phenyl optionally substituted with one to three Cl, Br, F, I,; A is C1-C 7 linear, branched optionally independently substituted with one to three substituents chosen from amino, cyano, carboxy, carboxamido, halogen, hydroxyl, nitro, phenyl, C 1-6 linear or branched alkyl and C 1-6 linear or branched alkoxy; E is -COORe, -SO 3 Re, -CONHRe, -CONHSO 2 Re, -SO 2 NH-CO(Rf), tetrazol-5-yl, 5-oxo-1,2,4-oxadiazol-3-yl, 5-oxo-1,2,4-thiadiazol-3-yl, 5-thioxo-1,2,4-oxadiazol-3-yl, 5-thioxo-1,2,4-thiadiazol-3-yl, 3-oxo-1,2,4-oxadiazol-5-yl, N3,5-dioxo-5-oxadiazolidino, 2-oxo1,3,4-oxadiazol-2-yl, 3-oxol,2,4-triazol-5-yl or 2,dioxo-benzothiadiazin-6-yl, wherein each Re is independently hydrogen, C 1-4 alkyl or phenyl, and Rf is C 1-4 alkyl or aryl; G is C 1-4 linear or branched alkyl optionally substituted with a substituent chosen from hydroxyl, a cyano, C 1-6 linear or branched alkyl and C 1-6 linear or branched alkoxy; M is a methylene group, oxygen, -N(Rb)-, or -S m -, where m is an integer of 0-2; J is an optionally mono- or di-substituted phenyl, naphthyl, benzothienyl, benzopyrrolyl, benzimidazolyl, indolyl; each substituent on said aromatic or heteroaromatic groups is chosen from halogen, hydroxyl, cyano, C 1-4 linear or branched alkyl, C 1-4 linear or branched alkoxy, C 1-6 linear or branched alkylthio, C 1-6 linear or branched alkylsulfonyl, phenylsulfonyl, C 1-6 linear or branched acyl, C 1-6 linear or branched acylamino, trihalomethyl, trihalomethyxy, phenyl, oxo, -COORa, -CON(Rc)Ra, -SO 2 N(Rc)Ra, N(Rc)Ra and phenoxy optionally substituted by one or more halogens; Ra,Rb and Rc are each independently C1-3 alkyl or hydrogen;