mhurhangee/ep-ind-claims huggingface dataset:
A method of screening for a colorectal neoplasm in a subject, consisting of: assaying a biological sample from the subject by detecting the methylation state of: (a) the Septin 9 gene; and (b) at least one additional marker gene selected from the Ikaros family zinc-finger 1 (IKZF1) gene and the branched-chain aminotransferase 1 (BCAT1) gene, wherein methylation of Septin 9 and the one additional marker gene is indicative of a colorectal neoplasm in the subject. assaying a biological sample from the subject by detecting the methylation state of: (a) the Septin 9 gene; and (b) at least one additional marker gene selected from the Ikaros family zinc-finger 1 (IKZF1) gene and the branched-chain aminotransferase 1 (BCAT1) gene, (a) the Septin 9 gene; and (b) at least one additional marker gene selected from the Ikaros family zinc-finger 1 (IKZF1) gene and the branched-chain aminotransferase 1 (BCAT1) gene, wherein methylation of Septin 9 and the one additional marker gene is indicative of a colorectal neoplasm in the subject.
A method of producing a composite block intended for the production of a dental prosthesis, said method comprising the following steps: a) infiltrating a support made in a ceramic material, with a liquid resin; b) curing the liquid resin impregnating the support; characterized in that in step b), the liquid resin is subjected to a pressure of more than 300 bar, and in that a volume of liquid resin that is greater than the volume of the open pores of the support by at least 2% is caused to penetrate into the support and to cure therein, said volumes being measured at a temperature of 20°C and at a pressure of 1 bar. a) infiltrating a support made in a ceramic material, with a liquid resin; b) curing the liquid resin impregnating the support;
Cover for waste collection bin adapted to be pivotally mounted on a tank of the bin about a pivoting axis, comprising at least a first pivoting arm extending beyond a surface of the cover closing the tank, this arm comprising: - a first side forming an angle greater than 65° with said pivoting axis, and comprising a first through hole formed in this first side, this first hole being shaped to receive a member for pivotally mounting the cover on the tank, - a second side forming an angle greater than 65° and preferably equal to 90° with said pivoting axis, comprising a second through hole formed in this second side, arranged opposite the first hole in the direction of the pivoting axis and shaped to receive said mounting member, - a reinforcement wall of the cover arm, radially integral with the first side with respect to the pivoting axis, over at least a first angular sector having an opening angle α of at least 60°, this reinforcement wall extending towards the second side parallel to the pivoting axis by winding partially around this axis, this reinforcement wall having an axial dimension of at least 10 mm over the largest part at least of this first angular sector, and preferably over its entirety, characterised in that the second side is radially disengaged from said reinforcement wall as well as from the first side over a second angular sector with respect to the pivoting axis having an opening angle β of at least 200°, this second angular sector comprising the first angular sector. - a first side forming an angle greater than 65° with said pivoting axis, and comprising a first through hole formed in this first side, this first hole being shaped to receive a member for pivotally mounting the cover on the tank, - a second side forming an angle greater than 65° and preferably equal to 90° with said pivoting axis, comprising a second through hole formed in this second side, arranged opposite the first hole in the direction of the pivoting axis and shaped to receive said mounting member, - a reinforcement wall of the cover arm, radially integral with the first side with respect to the pivoting axis, over at least a first angular sector having an opening angle α of at least 60°, this reinforcement wall extending towards the second side parallel to the pivoting axis by winding partially around this axis, this reinforcement wall having an axial dimension of at least 10 mm over the largest part at least of this first angular sector, and preferably over its entirety,
A framework-chamber arrangement for a sole structure of an article of footwear, the framework-chamber arrangement comprising: a heel fluid-filled chamber forming a plurality of arms extending laterally between upper and lower regions of the heel fluid-filled chamber; a forefoot fluid-filled chamber forming a plurality of arms extending laterally between the upper and lower regions of the forefoot fluid-filled chamber and at least one conduit (160, 162) interconnecting two or more of the arms of the forefoot fluid-filled chamber and configured to direct fluid flow between the interconnected arms; and a framework receiving and retaining the lower regions of the heel and forefoot fluid-filled chambers within a plurality of recesses (170, 180) formed in an upper portion of the framework, the plurality of recesses including a plurality of channels receiving and retaining lower regions of the arms of the forefoot and heel fluid-filled chambers, the plurality of channels including at least one forefoot channel corresponding with the at least one chamber conduit and interconnecting two or more of the plurality of forefoot channels. a heel fluid-filled chamber forming a plurality of arms extending laterally between upper and lower regions of the heel fluid-filled chamber; a forefoot fluid-filled chamber forming a plurality of arms extending laterally between the upper and lower regions of the forefoot fluid-filled chamber and at least one conduit (160, 162) interconnecting two or more of the arms of the forefoot fluid-filled chamber and configured to direct fluid flow between the interconnected arms; and a framework receiving and retaining the lower regions of the heel and forefoot fluid-filled chambers within a plurality of recesses (170, 180) formed in an upper portion of the framework, the plurality of recesses including a plurality of channels receiving and retaining lower regions of the arms of the forefoot and heel fluid-filled chambers, the plurality of channels including at least one forefoot channel corresponding with the at least one chamber conduit and interconnecting two or more of the plurality of forefoot channels.
An ultra-low consumption wireless communication receiver module for an implantable medical device, the medical device comprising: at least one electrode for collecting a pulse modulated input communication signal transmitted by human body communication, wherein the receiver module comprises at least one low-noise amplifier, LNA, stage (72; 72-1, 72-2, 72-3) receiving the modulated input communication signal, characterized in that the LNA stage (72; 72-1, 72-2, 72-3) is a non-linear stage comprising a pair of complementary transistors (74, 76) arranged as a voltage inverter circuit having an input coupled to the electrode collecting the modulated input communication signal, wherein the input and an output of the voltage inverter circuit are coupled to each other, and in that the input of the LNA stage (72; 72-1, 72-2, 72-3) is polarized to an intermediate operating point voltage (V DD /2) between a supply voltage (V DD) of the complementary transistor pair (74, 76) and a ground voltage.
A closure comprising: - a first part able to be attached to a liquid container, said first part having a pouring orifice for pouring the contents of the container, - a second part removably coupled to the first part to close and open said pouring orifice, said second part being moveable relative to said first part between a first configuration and a second configuration, wherein: - the second part comprises a storage chamber for storing a product to be dispensed into the container and a dispensing opening for allowing the product to flow out of the storage chamber toward the interior of the container, - the first part comprises a closing member and at least one passage opening, - said at least one passage opening is able to put the dispensing opening of the storage chamber in communication with the interior of the container, - in said first configuration, said closing member engages said dispensing opening to close said dispensing opening, - upon first opening, said second part moves relative to said first part from the first configuration to the second configuration to cause said dispensing opening to disengage from said closing member and allow the product in the storage chamber to flow out into the container through the dispensing opening and said at least one passage opening, characterized in that: - in said first configuration, said first part engages said second part to form a first sealing portion, a second sealing portion and a safety chamber is arranged between the first sealing portion and the second sealing portion. - a first part able to be attached to a liquid container, said first part having a pouring orifice for pouring the contents of the container, - a second part removably coupled to the first part to close and open said pouring orifice, said second part being moveable relative to said first part between a first configuration and a second configuration, - the second part comprises a storage chamber for storing a product to be dispensed into the container and a dispensing opening for allowing the product to flow out of the storage chamber toward the interior of the container, - the first part comprises a closing member and at least one passage opening, - said at least one passage opening is able to put the dispensing opening of the storage chamber in communication with the interior of the container, - in said first configuration, said closing member engages said dispensing opening to close said dispensing opening, - upon first opening, said second part moves relative to said first part from the first configuration to the second configuration to cause said dispensing opening to disengage from said closing member and allow the product in the storage chamber to flow out into the container through the dispensing opening and said at least one passage opening, - in said first configuration, said first part engages said second part to form a first sealing portion, a second sealing portion and a safety chamber is arranged between the first sealing portion and the second sealing portion.
A process for purifying recombinant P. falciparum circumsporozoite protein (rCSP), said process comprising: (a) obtaining a bacterial cell lysate preparation comprising recombinant P. falciparum circumsporozoite protein dimer; (b) separating the bacterial cell lysate preparation of step (a) into a soluble fraction comprising the recombinant P. falciparum circumsporozoite protein dimer, and an insoluble fraction; (c) separating the recombinant P. falciparum circumsporozoite protein dimer in the soluble fraction of step (b) from host cell proteins in the soluble fraction; and (d) subjecting the recombinant P. falciparum circumsporozoite protein dimer obtained in step (c) to preferential reducing conditions, wherein the preferential reducing conditions comprise a mild reducing agent selected from DTT, cysteine, acetylcysteine, glutathione, monothioglycerol, thioglycolate, dithiothreitol, dithioerythritol, 2-Mercaptoethanol (β-mercaptoethanol), TCEP-HCl (pure, crystalline Tris(2-carboxyethyl)phosphine hydrochloride), and 2-Mercaptoethylamine-HCI (2-MEA), and a disaggregating agent selected from urea, arginine, guanidine HCl, and a detergent, wherein the preferential reducing conditions reduce intermolecular disulfide bonds while preserving each monomer's intramolecular disulfide bonds; thereby obtaining purified recombinant P. falciparum circumsporozoite protein without the need for denaturing and refolding the protein, wherein the purified recombinant P. falciparum circumsporozoite protein obtained is N-terminally intact from residue 25 of SEQ ID NO: 1, and wherein not more than 10% of the purified recombinant P. falciparum circumsporozoite protein obtained is dimerized, and not more than 5% of the purified recombinant P. falciparum circumsporozoite protein obtained is present as high molecular weight aggregates. (a) obtaining a bacterial cell lysate preparation comprising recombinant P. falciparum circumsporozoite protein dimer; (b) separating the bacterial cell lysate preparation of step (a) into a soluble fraction comprising the recombinant P. falciparum circumsporozoite protein dimer, and an insoluble fraction; (c) separating the recombinant P. falciparum circumsporozoite protein dimer in the soluble fraction of step (b) from host cell proteins in the soluble fraction; and (d) subjecting the recombinant P. falciparum circumsporozoite protein dimer obtained in step (c) to preferential reducing conditions, wherein the preferential reducing conditions comprise a mild reducing agent selected from DTT, cysteine, acetylcysteine, glutathione, monothioglycerol, thioglycolate, dithiothreitol, dithioerythritol, 2-Mercaptoethanol (β-mercaptoethanol), TCEP-HCl (pure, crystalline Tris(2-carboxyethyl)phosphine hydrochloride), and 2-Mercaptoethylamine-HCI (2-MEA), and a disaggregating agent selected from urea, arginine, guanidine HCl, and a detergent, wherein the preferential reducing conditions reduce intermolecular disulfide bonds while preserving each monomer's intramolecular disulfide bonds;
A food holder for a food slicer, the food holder comprising a tubular section and a plate extending across the tubular section, the plate defining a top face and a bottom face, the bottom face comprising a food-engaging surface moveable in a cutting direction relative to a cutting surface of the food slicer to cut a food product held between the food-engaging surface and the cutting surface, characterized in that the food-engaging surface is inclined or sloped with respect to the cutting surface substantially from an uppermost point at the front of the tubular section of the food holder to a lowermost point at the rear of the tubular section of the food holder, said front and rear of the tubular section being defined with reference to said cutting direction, so that at least a portion of the food-engaging surface is arranged to be positioned behind the food product with respect to the cutting direction during use to exert a pushing force on the back of the food product to push it along the cutting surface of the food slicer.
A cartridge to be used in an apparatus main body of an image forming apparatus, the cartridge comprising: a process unit (20, 32) to be used to form an image; a first member including a first resin material; a second member including a second resin material having higher flame retardant capability than the first resin material; and an electrode member including a contact section configured to be supplied with power from the apparatus main body of the image forming apparatus, the electrode member being configured to electrically connect with the process unit (20, 32), wherein the first member is a part of a frame of the cartridge, wherein the second resin material of the second member has a greater density than the first resin material of the first member, and at least a part of the second member is located at a position closer to the contact section than a part of the first member closest to the contact section and between the contact section and the part of the first member closest to the contact section. a process unit (20, 32) to be used to form an image; a first member including a first resin material; a second member including a second resin material having higher flame retardant capability than the first resin material; and an electrode member including a contact section configured to be supplied with power from the apparatus main body of the image forming apparatus, the electrode member being configured to electrically connect with the process unit (20, 32), wherein the first member is a part of a frame of the cartridge, wherein the second resin material of the second member has a greater density than the first resin material of the first member, and at least a part of the second member is located at a position closer to the contact section than a part of the first member closest to the contact section and between the contact section and the part of the first member closest to the contact section.
An image display device comprising: a light source; a wavelength conversion layer containing quantum dots; a polarizing plate disposed on the observer side with respect to the wavelength conversion layer; and a light reflecting layer provided on an observer side with respect to the wavelength conversion layer and disposed on the polarizing plate, and including, in a reflection wavelength region, a peak wavelength of the light source that emits excitation light to be used for emission of the quantum dots, wherein the light source is arranged opposite to the observer side and the wavelength conversion layer, the polarizing plate, and the light reflecting layer are arranged in this order from the light source, wherein the light reflecting layer is a polarizing reflective layer, the polarizing reflective layer is a cholesteric liquid crystal layer, and a quarter-wave plate is disposed between the cholesteric liquid crystal layer and the polarizing plate. a light source; a wavelength conversion layer containing quantum dots; a polarizing plate disposed on the observer side with respect to the wavelength conversion layer; and a light reflecting layer provided on an observer side with respect to the wavelength conversion layer and disposed on the polarizing plate, and including, in a reflection wavelength region, a peak wavelength of the light source that emits excitation light to be used for emission of the quantum dots, wherein the light source is arranged opposite to the observer side and the wavelength conversion layer, the polarizing plate, and the light reflecting layer are arranged in this order from the light source, wherein the light reflecting layer is a polarizing reflective layer, the polarizing reflective layer is a cholesteric liquid crystal layer, and a quarter-wave plate is disposed between the cholesteric liquid crystal layer and the polarizing plate.
An in vitro method for measuring the in vivo turnover of Aβ in the blood of a subject, the method comprising: (a) determining by mass spectrometry the amount of labelled Aβ, or the amount of both labelled Aβ and unlabelled Aβ in a blood sample obtained from the subject; and (b) calculating the turnover of Aβ using the amount of labelled Aβ, or the amount of both labelled Aβ and unlabelled Aβ, determined in step (a), wherein (i) Aβ turnover is calculated from the amount of labelled Aβ, or the amount of labelled Aβ and unlabelled Aβ, in a sample obtained between 15 minutes and 4 hours after oral or intravenous administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject; or (ii) Aβ turnover is determined from the peak of labelled Aβ production occurring at between about 1 and 5 hours after oral bolus administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject, or between about 5 and 10 hours after intravenous administration by a 9 hour infusion has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject. (a) determining by mass spectrometry the amount of labelled Aβ, or the amount of both labelled Aβ and unlabelled Aβ in a blood sample obtained from the subject; and (b) calculating the turnover of Aβ using the amount of labelled Aβ, or the amount of both labelled Aβ and unlabelled Aβ, determined in step (a), wherein (i) Aβ turnover is calculated from the amount of labelled Aβ, or the amount of labelled Aβ and unlabelled Aβ, in a sample obtained between 15 minutes and 4 hours after oral or intravenous administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject; or (ii) Aβ turnover is determined from the peak of labelled Aβ production occurring at between about 1 and 5 hours after oral bolus administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject, or between about 5 and 10 hours after intravenous administration by a 9 hour infusion has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject. (i) Aβ turnover is calculated from the amount of labelled Aβ, or the amount of labelled Aβ and unlabelled Aβ, in a sample obtained between 15 minutes and 4 hours after oral or intravenous administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject; or (ii) Aβ turnover is determined from the peak of labelled Aβ production occurring at between about 1 and 5 hours after oral bolus administration has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject, or between about 5 and 10 hours after intravenous administration by a 9 hour infusion has begun of at least one amino acid labelled with a stable non-radioactive isotope to the subject.
A window system comprising: a window (1; 101) including a frame (2; 102) and a sash (3; 103), each having a plurality of members defining a frame and a sash plane, respectively, said sash (3; 103) being connected to the frame (2; 102) by means of at least one hinge connection, so that the sash (3; 103) can be moved from a closed position to an open position, and into an intermediate ventilating position, in which ventilating position the sash plane forms an angle within a limited angle range with the frame plane to provide at least one ventilating aperture (20; 120) in the circumferential of the frame (2; 102) and/or sash (3; 103), and said window system further comprising a screening arrangement arranged to cover the said ventilating aperture (20; 120) in the ventilating position, wherein said screening arrangement comprises at least one screening element (21; 121) incorporated in at least one member of said frame (2; 102) and/or sash (3; 103), characterized in that said at least one screening element (21; 121) includes a ventilating passage (22; 122) with a first set of openings (22a; 122a) in a first face (23; 123) of the at least one frame or sash member and a second set of openings (22b; 122b) in a second face (24; 124) of the at least one frame or sash member to provide connection to the at least one ventilating aperture (20; 120) in the ventilating position of the window (1; 101). a window (1; 101) including a frame (2; 102) and a sash (3; 103), each having a plurality of members defining a frame and a sash plane, respectively, said sash (3; 103) being connected to the frame (2; 102) by means of at least one hinge connection, so that the sash (3; 103) can be moved from a closed position to an open position, and into an intermediate ventilating position, in which ventilating position the sash plane forms an angle within a limited angle range with the frame plane to provide at least one ventilating aperture (20; 120) in the circumferential of the frame (2; 102) and/or sash (3; 103), and said window system further comprising a screening arrangement arranged to cover the said ventilating aperture (20; 120) in the ventilating position, wherein said screening arrangement comprises at least one screening element (21; 121) incorporated in at least one member of said frame (2; 102) and/or sash (3; 103), characterized in that said at least one screening element (21; 121) includes a ventilating passage (22; 122) with a first set of openings (22a; 122a) in a first face (23; 123) of the at least one frame or sash member and a second set of openings (22b; 122b) in a second face (24; 124) of the at least one frame or sash member to provide connection to the at least one ventilating aperture (20; 120) in the ventilating position of the window (1; 101).