A compound of Formula: or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: ---- is an optional bond; ring A is independently selected from a C 3-10 carbocycle and a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), NC(=NH)NH 2, O, and S; ring B is independently selected from a aryl and a 5- to 10-membered heterocycle; L 1 is independently selected from a bond, -CR 5 R 5 -, -CHR 5 CHR 5 -, -CR 5 =CR 5 -, -C≡C-, -OCH 2 -, -CHR 5 NH-, -CH 2 O-, -SCH 2 -, -SO 2 CH 2 -, and -CH 2 NH-; R 1 is, independently at each occurrence, selected from halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, OH, =O, OCH 2 F, OCHF 2, OCF 3, CF3, CN, NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 (C 1-4 alkyl), CO(C 1-4 alkyl), -CH 2 NH 2, -CONH 2, -CONH(C 1-4 alkyl), -OCH 2 CO 2 H, -NHCO(C 1-4 alkyl), -NHCO 2 (C 1-4 alkyl), -NHSO 2 (C 1-4 alkyl), -SO 2 NH 2, and -C(=NH)NH 2; R 2 is a 5- to 7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), O, and S 2, wherein said heterocycle is substituted with 0-2 R 2a; R 2a is, independently at each occurrence, selected from halogen, C 1-4 alkyl, -CH 2 OH, C 1-4 alkoxy, OH, CF 3, OCF 3, OCH 2 F, OCHF 2, CN, NH 2, CO 2 H, CO 2 (C 1-4 alkyl), COC 1-4 alkyl, -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, -SO 2 (C 1-4 alkyl), -SO 2 NH 2, -SO 2 NH(C 1-4 alkyl), and -SO 2 N(C 1-4 alkyl) 2; R 3 is independently selected from H and C 1-4 alkyl; alternatively, L 1 and R 3, together with the nitrogen atom to which they are attached, form a ring; R 4 is selected from H, C 1-4 alkyl, hydroxyl, F, CF 3, and C 3-6 cycloalkyl; R 5 is selected from H and C 1-4 alkyl; R 6 is selected from H, halogen, C OH, and C O(C 1-4 alkyl); R 7 is selected from H, C 1-4 alkyl, and CF 3; alternatively, R 6 and R 7 together are =O; and R 8 is, independently at each occurrence, selected from H, halogen, NHCO 2 C 1-4 alkyl, CN, OH, O-C 1-4 alkyl, CF 3, -OCF 3, -OCHF 2, -CHF 2, -CH 2 F, CO 2 H, CO 2 (C 1-4 alkyl), -CH 2 CO 2 H, -(CH 2) 2 CO 2 H, -CH 2 CO 2 (C 1-4 alkyl), -(CH 2) 2 CO 2 (C 1-4 alkyl), NH 2, -CH 2 NH 2, -NHCO(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-3 O(C 1-4 alkyl), NHCO 2 CH 2 CH(C 1-4 alkyl)O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 OH, -NHCO 2 CH 2 CO 2 H, -CH 2 NHCO 2 (C 1-4 alkyl), -NHC NH(C 1-4 alkyl), -NHC N(C 1-4 alkyl) 2, NHC NH(C 1-4 alkyl)N(5- to 6-membered heterocycle), -NHSO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, and -CH 2 CONH 2. ---- is an optional bond; ring A is independently selected from a C 3-10 carbocycle and a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), NC(=NH)NH 2, O, and S; ring B is independently selected from a aryl and a 5- to 10-membered heterocycle; L 1 is independently selected from a bond, -CR 5 R 5 -, -CHR 5 CHR 5 -, -CR 5 =CR 5 -, -C≡C-, -OCH 2 -, -CHR 5 NH-, -CH 2 O-, -SCH 2 -, -SO 2 CH 2 -, and -CH 2 NH-; R 1 is, independently at each occurrence, selected from halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, OH, =O, OCH 2 F, OCHF 2, OCF 3, CF3, CN, NH 2, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2, CO 2 (C 1-4 alkyl), CO(C 1-4 alkyl), -CH 2 NH 2, -CONH 2, -CONH(C 1-4 alkyl), -OCH 2 CO 2 H, -NHCO(C 1-4 alkyl), -NHCO 2 (C 1-4 alkyl), -NHSO 2 (C 1-4 alkyl), -SO 2 NH 2, and -C(=NH)NH 2; R 2 is a 5- to 7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), O, and S 2, wherein said heterocycle is substituted with 0-2 R 2a; R 2a is, independently at each occurrence, selected from halogen, C 1-4 alkyl, -CH 2 OH, C 1-4 alkoxy, OH, CF 3, OCF 3, OCH 2 F, OCHF 2, CN, NH 2, CO 2 H, CO 2 (C 1-4 alkyl), COC 1-4 alkyl, -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, -SO 2 (C 1-4 alkyl), -SO 2 NH 2, -SO 2 NH(C 1-4 alkyl), and -SO 2 N(C 1-4 alkyl) 2; R 3 is independently selected from H and C 1-4 alkyl; alternatively, L 1 and R 3, together with the nitrogen atom to which they are attached, form a ring; R 4 is selected from H, C 1-4 alkyl, hydroxyl, F, CF 3, and C 3-6 cycloalkyl; R 5 is selected from H and C 1-4 alkyl; R 6 is selected from H, halogen, C OH, and C O(C 1-4 alkyl); R 7 is selected from H, C 1-4 alkyl, and CF 3; alternatively, R 6 and R 7 together are =O; and R 8 is, independently at each occurrence, selected from H, halogen, NHCO 2 C 1-4 alkyl, CN, OH, O-C 1-4 alkyl, CF 3, -OCF 3, -OCHF 2, -CHF 2, -CH 2 F, CO 2 H, CO 2 (C 1-4 alkyl), -CH 2 CO 2 H, -(CH 2) 2 CO 2 H, -CH 2 CO 2 (C 1-4 alkyl), -(CH 2) 2 CO 2 (C 1-4 alkyl), NH 2, -CH 2 NH 2, -NHCO(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-3 O(C 1-4 alkyl), NHCO 2 CH 2 CH(C 1-4 alkyl)O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 OH, -NHCO 2 CH 2 CO 2 H, -CH 2 NHCO 2 (C 1-4 alkyl), -NHC NH(C 1-4 alkyl), -NHC N(C 1-4 alkyl) 2, NHC NH(C 1-4 alkyl)N(5- to 6-membered heterocycle), -NHSO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, and -CH 2 CONH 2.