A compound of Formula I-A or a pharmaceutically acceptable salt thereof: wherein: T is CR 6 or N; U is CR 5 or N; V is CR 4 or N; W is CR 3 or N; X is CR 2 or N; and provided that includes no more than 3 nitrogen atoms in the ring; E is selected from the group consisting of NR a R b, C 1 -C 3 alkylene-NR a R b, C 1 -C 3 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkylene-(C 3 -C 8 cycloalkyl), 4- to 10-membered heterocyclyl, and C 1 -C 3 alkylene-(4- to 10-membered heterocyclyl) wherein the C 1 -C 3 alkylene-NR a R b, C 1 -C 3 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkylene-(C 3 -C 8 cycloalkyl), 4- to 10-membered heterocyclyl, or C 1 -C 3 alkylene-(4- to 10-membered heterocyclyl) is unsubstituted or substituted with one or more halogen, hydroxyl, C 1 -C 3 alkyl, or C 1 -C 3 alkoxyl; R a and R b are each, independently, H or unsubstituted C 1 -C 3 alkyl; R 1 is (CR c R d) n -(C 6 -C 10 aryl) or (CR c R d) n -(5- to 10-membered heteroaryl) wherein the aryl or heteroaryl is unsubstituted or substituted with one or more halogen, hydroxyl, unsubstituted C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; R c and R d are each, independently, H, unsubstituted C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; n is 0 or 1; each of R 2, R 3, R 4, Rs, and R 6, when present, is, independently, selected from the group consisting of H, halogen, deuterium, hydroxyl, cyano, unsubstituted C 1 -C 3 alkyl, and C 1 -C 3 alkyl substituted with one or more halogen or deuterium; each of R 7, Rs, R 9, R 10, R 11, R 12, and R 13 is, independently, H, halogen, unsubstituted Ci-C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; or, alternatively, R 8 and R 11, together form an unsubstituted C 1 -C 3 alkylene or a C 1 -C 3 alkylene substituted with one or more halogen; or, alternatively, R 9 and R 10, together form an unsubstituted C 1 -C 3 alkylene or a C 1 -C 3 alkylene substituted with one or more halogen; p is 0, 1, 2, 3, or 4; and each R 14 is, independently, selected from the group consisting of deuterium, halogen, hydroxyl, and cyano. T is CR 6 or N; U is CR 5 or N; V is CR 4 or N; W is CR 3 or N; X is CR 2 or N; and provided that includes no more than 3 nitrogen atoms in the ring; E is selected from the group consisting of NR a R b, C 1 -C 3 alkylene-NR a R b, C 1 -C 3 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkylene-(C 3 -C 8 cycloalkyl), 4- to 10-membered heterocyclyl, and C 1 -C 3 alkylene-(4- to 10-membered heterocyclyl) wherein the C 1 -C 3 alkylene-NR a R b, C 1 -C 3 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 8 cycloalkyl, C 1 -C 3 alkylene-(C 3 -C 8 cycloalkyl), 4- to 10-membered heterocyclyl, or C 1 -C 3 alkylene-(4- to 10-membered heterocyclyl) is unsubstituted or substituted with one or more halogen, hydroxyl, C 1 -C 3 alkyl, or C 1 -C 3 alkoxyl; R a and R b are each, independently, H or unsubstituted C 1 -C 3 alkyl; R 1 is (CR c R d) n -(C 6 -C 10 aryl) or (CR c R d) n -(5- to 10-membered heteroaryl) wherein the aryl or heteroaryl is unsubstituted or substituted with one or more halogen, hydroxyl, unsubstituted C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; R c and R d are each, independently, H, unsubstituted C 1 -C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; n is 0 or 1; each of R 2, R 3, R 4, Rs, and R 6, when present, is, independently, selected from the group consisting of H, halogen, deuterium, hydroxyl, cyano, unsubstituted C 1 -C 3 alkyl, and C 1 -C 3 alkyl substituted with one or more halogen or deuterium; each of R 7, Rs, R 9, R 10, R 11, R 12, and R 13 is, independently, H, halogen, unsubstituted Ci-C 3 alkyl, or C 1 -C 3 alkyl substituted with one or more halogen or deuterium; or, alternatively, R 8 and R 11, together form an unsubstituted C 1 -C 3 alkylene or a C 1 -C 3 alkylene substituted with one or more halogen; or, alternatively, R 9 and R 10, together form an unsubstituted C 1 -C 3 alkylene or a C 1 -C 3 alkylene substituted with one or more halogen; p is 0, 1, 2, 3, or 4; and each R 14 is, independently, selected from the group consisting of deuterium, halogen, hydroxyl, and cyano.