A weight-loss device for treatment of obesity in a patient comprising: a gastric balloon configured for positioning in a stomach lumen, said gastric balloon comprising: a gastric balloon surface having a proximal end and a distal end; a passage spanning between said proximal end and said distal end, wherein during use said passage substantially aligns in a direction from an esophageal sphincter toward a pyloric sphincter with said gastric balloon proximal end facing the esophageal sphincter and said gastric balloon distal end facing the pyloric sphincter; and a gastric balloon anchor connected to or extending from said gastric balloon surface configured to reliably position said gastric balloon in a stomach lumen during use; an elongated sleeve connected to said gastric balloon and configured for insertion into at least a portion of a patient's small intestine during use, said elongated sleeve comprising: a sleeve wall having an inner-facing surface that forms a sleeve lumen, wherein said sleeve lumen extends from a sleeve proximal end to a sleeve distal end; and said sleeve distal end is configured to be positioned during use at a distal region of the small intestine characterized in that said sleeve proximal end is connected to said gastric balloon distal end to provide a continuous pathway extension of said gastric balloon passage and wherein said elongated sleeve has a stored configuration adjacent to said gastric balloon surface distal end and a deployed configuration; and said stored configuration corresponds to said elongated sleeve that is within 5 mm of said gastric balloon distal end and said deployed configuration corresponds to a sleeve length between said sleeve distal and proximal ends that is between 50 cm and 500 cm. a gastric balloon configured for positioning in a stomach lumen, said gastric balloon comprising: a gastric balloon surface having a proximal end and a distal end; a passage spanning between said proximal end and said distal end, wherein during use said passage substantially aligns in a direction from an esophageal sphincter toward a pyloric sphincter with said gastric balloon proximal end facing the esophageal sphincter and said gastric balloon distal end facing the pyloric sphincter; and a gastric balloon anchor connected to or extending from said gastric balloon surface configured to reliably position said gastric balloon in a stomach lumen during use; a gastric balloon surface having a proximal end and a distal end; a passage spanning between said proximal end and said distal end, wherein during use said passage substantially aligns in a direction from an esophageal sphincter toward a pyloric sphincter with said gastric balloon proximal end facing the esophageal sphincter and said gastric balloon distal end facing the pyloric sphincter; and a gastric balloon anchor connected to or extending from said gastric balloon surface configured to reliably position said gastric balloon in a stomach lumen during use; an elongated sleeve connected to said gastric balloon and configured for insertion into at least a portion of a patient's small intestine during use, said elongated sleeve comprising: a sleeve wall having an inner-facing surface that forms a sleeve lumen, wherein said sleeve lumen extends from a sleeve proximal end to a sleeve distal end; and said sleeve distal end is configured to be positioned during use at a distal region of the small intestine characterized in that said sleeve proximal end is connected to said gastric balloon distal end to provide a continuous pathway extension of said gastric balloon passage and wherein said elongated sleeve has a stored configuration adjacent to said gastric balloon surface distal end and a deployed configuration; and said stored configuration corresponds to said elongated sleeve that is within 5 mm of said gastric balloon distal end and said deployed configuration corresponds to a sleeve length between said sleeve distal and proximal ends that is between 50 cm and 500 cm. a sleeve wall having an inner-facing surface that forms a sleeve lumen, wherein said sleeve lumen extends from a sleeve proximal end to a sleeve distal end; and said sleeve distal end is configured to be positioned during use at a distal region of the small intestine characterized in that said sleeve proximal end is connected to said gastric balloon distal end to provide a continuous pathway extension of said gastric balloon passage and wherein said elongated sleeve has a stored configuration adjacent to said gastric balloon surface distal end and a deployed configuration; and said stored configuration corresponds to said elongated sleeve that is within 5 mm of said gastric balloon distal end and said deployed configuration corresponds to a sleeve length between said sleeve distal and proximal ends that is between 50 cm and 500 cm.