mhurhangee/ep-ind-claims huggingface dataset:
A system for modifying tissue to provide a therapeutic benefit to a patient, the system comprising: a tissue treatment device for treating target tissue comprising: a tissue treatment element constructed and arranged to apply a tissue modifying agent to the target tissue, wherein the tissue treatment element is configured to expand prior to the delivery of the tissue modifying agent; and a shaft with a proximal end and a distal portion and a lumen, wherein the tissue treatment element is positioned on the distal portion of the shaft; a tissue modifying agent delivery unit configured to deliver the tissue modifying agent to the tissue treatment element through the lumen; and one or more deployable occluding elements for preventing migration of the tissue modifying agent to non-target tissue; wherein the one or more deployable occluding elements are positioned within the lumen; a translatable push rod configured to be advanced to deploy the one or more deployable occluding elements from a distal end of the lumen; wherein the target tissue comprises duodenal mucosal tissue, and wherein the system is configured to modify the target tissue to provide the therapeutic benefit. a tissue treatment device for treating target tissue comprising: a tissue treatment element constructed and arranged to apply a tissue modifying agent to the target tissue, wherein the tissue treatment element is configured to expand prior to the delivery of the tissue modifying agent; and a shaft with a proximal end and a distal portion and a lumen, wherein the tissue treatment element is positioned on the distal portion of the shaft; a tissue treatment element constructed and arranged to apply a tissue modifying agent to the target tissue, wherein the tissue treatment element is configured to expand prior to the delivery of the tissue modifying agent; and a shaft with a proximal end and a distal portion and a lumen, wherein the tissue treatment element is positioned on the distal portion of the shaft; a tissue modifying agent delivery unit configured to deliver the tissue modifying agent to the tissue treatment element through the lumen; and one or more deployable occluding elements for preventing migration of the tissue modifying agent to non-target tissue; wherein the one or more deployable occluding elements are positioned within the lumen; a translatable push rod configured to be advanced to deploy the one or more deployable occluding elements from a distal end of the lumen; wherein the target tissue comprises duodenal mucosal tissue, and wherein the system is configured to modify the target tissue to provide the therapeutic benefit.
A compound for use in a method of treatment of a disease selected from the group consisting of Crohn's disease, colitis, inflammatory bowel disease, and multiple sclerosis, wherein said compound has the structural formula:
A catheter (128,204, 48,271,281) comprising: a multi-layer construction shaft for delivering cryogen to a treatment area, a proximal end configured to connect to a cryogen spray apparatus; more than one inner diameter dimension along a length of the catheter (128, 204, 48, 271, 281); a nozzling transition from a larger inner diameter shaft at the proximal end of the catheter (128,204, 48,271,281) to a smaller inner diameter shaft; an open- ended distal end configured for the output of cryogen spray, said distal end comprising blunt tip (206, 13, 10) geometry; a first patterned cut along at least a portion of the larger inner diameter shaft of the catheter; and a second patterned cut along at least a portion of the smaller inner diameter shaft of the catheter; wherein the larger inner diameter shaft has a flexibility that is less than a flexibility of the smaller inner diameter shaft. a multi-layer construction shaft for delivering cryogen to a treatment area, a proximal end configured to connect to a cryogen spray apparatus; more than one inner diameter dimension along a length of the catheter (128, 204, 48, 271, 281); a nozzling transition from a larger inner diameter shaft at the proximal end of the catheter (128,204, 48,271,281) to a smaller inner diameter shaft; an open- ended distal end configured for the output of cryogen spray, said distal end comprising blunt tip (206, 13, 10) geometry; a first patterned cut along at least a portion of the larger inner diameter shaft of the catheter; and a second patterned cut along at least a portion of the smaller inner diameter shaft of the catheter; wherein the larger inner diameter shaft has a flexibility that is less than a flexibility of the smaller inner diameter shaft.
Coolant distributor for a machine tool, having a connection unit which is configured for attachment to the machine frame, said connection unit having a connection surface, onto which at least one supply channel for the coolant opens out, characterised by a guiding device which is arranged on the connection unit, said guiding device having at least one contact surface which runs at an inclination to the connection surface at an angle of inclination (α), a distribution unit which has a distribution surface, onto which at least one distribution channel opens out and which has at least one counter contact surface allocated to the contact surface, said counter contact surface running at an inclination with respect to the distribution surface at the angle of inclination (α), wherein the distribution unit is able to be moved in a connection direction extending in parallel to the contact surface relative to the connection unit in order to establish or disconnect a connection between the distribution unit and the connection unit, and wherein, in the event of a connection being established between the distribution unit and the connection unit, the counter contact surface abutting on the contact surface presses the distribution surface against the connection surface.
Pressure vessel for receiving and storing cryogenic fluids, in particular cryogenic liquids, said pressure vessel being composed of a metal vessel that forms a liner and a reinforcement made of fiber-reinforced plastic applied to the liner, characterized in that the liner is made of a non-magnetic metal alloy having a fully austenitic face-centered cubic lattice structure and, in order to increase the yield strength Rp 0,2 of at least 800 MPa or more, prior to applying the reinforcement made of fiber-reinforced plastic, said liner is subjected to a nitriding treatment at a temperature of more than 1,000°C, in particular at a temperature range between 1,000 and 1,200°C, by means of nitrogen or ammonia.
Expansion anchor having a bolt that has a neck region and an expansion region adjoining the neck region, in which expansion region the bolt tapers towards the neck region, wherein the bolt has a groove, in the neck region, extending along the bolt, and having an expansion sleeve that at least in part surrounds the bolt and that has a web on its inner side, wherein the web engages at least in certain regions in the groove in the neck region, and wherein the wall thickness of the expansion sleeve is locally increased by the web, wherein the groove provided in the neck region of the bolt extends up to the expansion region of the bolt, wherein the expansion sleeve is displaceable from the neck region into the expansion region with radial expansion of the expansion sleeve along the bolt, wherein the web, when the expansion sleeve is moved from the neck region into the expansion region, enters the expansion region at least in certain regions and is pushed radially outwards by the expansion region, characterized in that the web is arranged such that, when the expansion anchor is used as intended, it runs onto an inclined surface in the expansion region and is pushed radially outwards. having a bolt that has a neck region and an expansion region adjoining the neck region, in which expansion region the bolt tapers towards the neck region, wherein the bolt has a groove, in the neck region, extending along the bolt, and having an expansion sleeve that at least in part surrounds the bolt and that has a web on its inner side, wherein the web engages at least in certain regions in the groove in the neck region, and wherein the wall thickness of the expansion sleeve is locally increased by the web, wherein the groove provided in the neck region of the bolt extends up to the expansion region of the bolt, wherein the expansion sleeve is displaceable from the neck region into the expansion region with radial expansion of the expansion sleeve along the bolt, wherein the web, when the expansion sleeve is moved from the neck region into the expansion region, enters the expansion region at least in certain regions and is pushed radially outwards by the expansion region, characterized in that the web is arranged such that, when the expansion anchor is used as intended, it runs onto an inclined surface in the expansion region and is pushed radially outwards.
A surgical accessory comprising: A tubular cutting element including a drive shaft with a distal end; and a cutting head mounted on the distal end, the cutting head comprising: a pair of first tissue-treating areas each including an abrading region with a plurality of cutting surfaces with respective abraded region cutting edges and a plurality of flutes oriented in an alternating manner with one another along a circumference of the cutting head; and a pair of second tissue-treating areas each including a window formed as an elongated opening in the cutting head and having opposite longitudinal sides defining first and second cutting edges (923, 924) located in substantially opposed and facing relation with one another, the window being in operative communication with an interior of the cutting head, wherein the first tissue-treating areas and the second tissue-treating areas are arranged in an alternating manner with one another along the periphery of the cutting head. A tubular cutting element including a drive shaft with a distal end; and a cutting head mounted on the distal end, the cutting head comprising: a pair of first tissue-treating areas each including an abrading region with a plurality of cutting surfaces with respective abraded region cutting edges and a plurality of flutes oriented in an alternating manner with one another along a circumference of the cutting head; and a pair of second tissue-treating areas each including a window formed as an elongated opening in the cutting head and having opposite longitudinal sides defining first and second cutting edges (923, 924) located in substantially opposed and facing relation with one another, the window being in operative communication with an interior of the cutting head, wherein the first tissue-treating areas and the second tissue-treating areas are arranged in an alternating manner with one another along the periphery of the cutting head. a pair of first tissue-treating areas each including an abrading region with a plurality of cutting surfaces with respective abraded region cutting edges and a plurality of flutes oriented in an alternating manner with one another along a circumference of the cutting head; and a pair of second tissue-treating areas each including a window formed as an elongated opening in the cutting head and having opposite longitudinal sides defining first and second cutting edges (923, 924) located in substantially opposed and facing relation with one another, the window being in operative communication with an interior of the cutting head, wherein the first tissue-treating areas and the second tissue-treating areas are arranged in an alternating manner with one another along the periphery of the cutting head.
Motor relay, in particular for track circuits, having a housing comprising a base plug plate and a cap having a window, in particular made of transparent plastic, for a display device (18, 18') and a rotatable flap for covering a test strip, c h a r a c t e r i s e d in that a carrier for receiving at least one circuit board having a circuit for electronically implementing the motor relay is provided, wherein the carrier has fastening elements (23, 24, 26) and mouldings which interact with the housing conceived for electromechanically implementing the motor relay.
Coupling arrangement, comprising a housing, a drive shaft and an output shaft, which are mounted rotatably in the housing, a gearwheel which is arranged such that it can be rotated about a rotational axis of the output shaft, and which is in toothing engagement with the drive shaft, two conical friction discs (20, 20') which are arranged concentrically within the gearwheel and on the output shaft such that they can be displaced axially and are fixed on the said output shaft so as to rotate with it, an axial adjustment apparatus for actuating a transmission arrangement, by means of which the two friction discs (20, 20') can be loaded into a frictionally locking connection with the gearwheel, in order to drive-connect the gearwheel to the output shaft via the two friction discs (20, 20'), it being possible for the transmission arrangement and the gearwheel to be transferred into positively locking engagement with respect to one another, in order to drive-connect the gearwheel to the output shaft via the transmission arrangement.
A user interface for a machine for preparing beverages, with the user interface comprising: - a support so configured as to be made integral with the machine, - at least one control button (17a to 17d) mounted on the support and comprising at least one bearing zone so configured as to be pressed by a user, - at least one light source, characterized in that it comprises at least one flexible part, a first portion of which supports the bearing zone of said button (17a to 17d) and a second portion is secured to the support, with said at least one part forming a light guide comprising a light inlet zone inside thereof, with said at least one light source being positioned in contact with or opposite said inlet zone of said at least one flexible part forming the light guide, with said inlet zone being provided close to said second portion so as to remain in the same position relative to said at least one light source whether the bearing zone is pressed or not. - a support so configured as to be made integral with the machine, - at least one control button (17a to 17d) mounted on the support and comprising at least one bearing zone so configured as to be pressed by a user, - at least one light source,
A gate valve for controlling the flow of material, said valve comprising a. a housing defining an opening through which material passes; b. a slideable blade moving relative to said housing between an open position and a closed position to control material flow through said opening; c. at least one lifting lug coupled with said housing and presenting an inclined surface for engagement with said blade; d. a cylinder having a shaft coupled with said blade to move said blade between open and closed positions; e. a bonnet (26, 34, 36) enclosing at least the shaft of said cylinder; characterised by f. a bonnet seal support through which said blade extends; g. a blade scraper which removes material from said blade as said blade retracts; and h. an elastomeric material received by said seal support and extending around said support on all sides while in contact with said housing; said elastomeric material including a continuous closed air passage and a ridge on its outer surface overlying said passage, whereby when said perpendicular force is applied to said blade said elastomeric material is compressed and said ridge engages said housing thereby displacing air from said passage in the area of application of said force moving the displaced air to other areas of said passage to thereby increase the pressure against said elastomeric material in said other areas. a. a housing defining an opening through which material passes; b. a slideable blade moving relative to said housing between an open position and a closed position to control material flow through said opening; c. at least one lifting lug coupled with said housing and presenting an inclined surface for engagement with said blade; d. a cylinder having a shaft coupled with said blade to move said blade between open and closed positions; e. a bonnet (26, 34, 36) enclosing at least the shaft of said cylinder; f. a bonnet seal support through which said blade extends; g. a blade scraper which removes material from said blade as said blade retracts; and h. an elastomeric material received by said seal support and extending around said support on all sides while in contact with said housing;
A catheter having a distal region and a proximal region, comprising: an elongate shaft extending from the distal region to the proximal region and defining a lumen therebetween; distal occlusion means disposed over a portion of the distal region of the elongate shaft; and occlusion activating means disposed over the elongate shaft, wherein the elongate shaft has an outer surface and the occlusion activating means comprises an outer member slidably disposed over the outer surface of the elongate shaft, the outer member having a distal end and a proximal region, and wherein the distal occlusion means comprises an expandable member having a distal region including a distal end and a proximal region including a proximal end, characterized in that the expandable member is disposed over the outer surface of the elongate shaft such that the distal end of the outer member is proximate the proximal end of the expandable member, and wherein the catheter further comprises a stop disposed on the elongate shaft positioned to limit distal travel of the expandable member, where the distal end of the expandable member contacts the stop. an elongate shaft extending from the distal region to the proximal region and defining a lumen therebetween; distal occlusion means disposed over a portion of the distal region of the elongate shaft; and occlusion activating means disposed over the elongate shaft, wherein the elongate shaft has an outer surface and the occlusion activating means comprises an outer member slidably disposed over the outer surface of the elongate shaft, the outer member having a distal end and a proximal region, and wherein the distal occlusion means comprises an expandable member having a distal region including a distal end and a proximal region including a proximal end, characterized in that the expandable member is disposed over the outer surface of the elongate shaft such that the distal end of the outer member is proximate the proximal end of the expandable member, and wherein the catheter further comprises a stop disposed on the elongate shaft positioned to limit distal travel of the expandable member, where the distal end of the expandable member contacts the stop.
A method of producing a 1,2,4-oxadiazole derivative represented by the following formula, which comprises reacting a compound represented by the following formula and a compound represented by the following formula in the presence of a basic compound; wherein Ar is an aromatic group or an aromatic group having substituent(s), W, X, Y and Z are each independently -S-, -N=, -CH= or -CR=, and one selected from W, X, Y and Z is -S-, and R is an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, a haloalkoxy group having 1 to 3 carbon atoms or a halogen atom, and the compound represented by the formula is reacted in an amount of 1.8 mol or more, per 1 mol of the compound represented by the formula. Ar is an aromatic group or an aromatic group having substituent(s), W, X, Y and Z are each independently -S-, -N=, -CH= or -CR=, and one selected from W, X, Y and Z is -S-, and R is an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, a haloalkoxy group having 1 to 3 carbon atoms or a halogen atom, and the compound represented by the formula is reacted in an amount of 1.8 mol or more, per 1 mol of the compound represented by the formula.
A stable, synthetic triligand capture agent that specifically binds Akt, wherein the capture agent comprises an anchor ligand, a secondary ligand, and a tertiary ligand, and the capture agent binds to a non-ATP and non-peptide substrate binding site of Akt and wherein binding of said capture agent to the binding site allosterically inhibits Akt activity wherein the anchor ligand consists of the peptide sequence Az8-VFYRLGY-CONH 2.
A modular lag screw comprising a distal part comprising a first leading end and a first trailing end, wherein the first trailing end includes a first tool engagement portion, and a proximal part comprising a second leading end and a second trailing end, wherein the second leading end includes a distal part engagement portion configured for an engagement with the first tool engagement portion of the first trailing end of the distal part and for transmitting rotational forces from the proximal part to the distal part, and wherein the second trailing end includes a second tool engagement portion, and an assembly element for firmly coupling the distal part and the proximal part when the first tool engagement portion of the distal part engages the distal part engagement portion of the proximal part, characterized in that the first tool engagement portion corresponds to the second tool engagement portion.
Cladding part for cladding a heat pump, comprising: • a casing element; • a soft foam layer disposed on an inner side of the casing member; and • a heavy foam layer arranged on the soft foam layer; wherein the cladding part is designed to be attached to the heat pump under pretension in such a way that, in the attached state, the heavy foam layer rests against an outer surface of the heat pump and the soft foam layer is compressed, wherein the density of the soft foam layer is 50 kg/m 3 or less and, wherein the density of the heavy foam layer is 100 kg/m 3 or more. • a casing element; • a soft foam layer disposed on an inner side of the casing member; and • a heavy foam layer arranged on the soft foam layer; wherein the cladding part is designed to be attached to the heat pump under pretension in such a way that, in the attached state, the heavy foam layer rests against an outer surface of the heat pump and the soft foam layer is compressed, wherein the density of the soft foam layer is 50 kg/m 3 or less and, wherein the density of the heavy foam layer is 100 kg/m 3 or more.