A tube holder comprising a support surface for securement to a patient's skin including a hydrocolloid adhesive layer bonded to an elastomeric film to provide skin compatible features including an elasticity similar to human skin; a base mounted on said support surface, said base having a length and a width; and wherein said base has a flat bottom surface extending widthwise entirely across said width of said base and a raised platform having an upper surface spaced from said bottom surface and extending widthwise not entirely across a portion of said base such that said platform has a width less than said width of said base, a first female strap extending substantially transversely from said base, said first female strap having a length extending from a fixed end carried on a side of said base to a free end and a plurality of apertures (58, 60) therein spaced along said length; a second female strap extending substantially transversely from said base at a position longitudinally spaced from said first female strap, said second female strap having a length extending from a fixed end carried on a side of said base to a free end and a plurality of apertures (62, 64) therein spaced along said length of said second female strap; and wherein each of said fixed ends of said first and second female straps is carried on a side of said platform upper surface; and a first male strap extending substantially transversely from said base, said first male strap having a length extending from a fixed end carried on a side of said base to a free end and carrying a plurality of flexible locking members along said length of said first male strap, said locking members being of a size to pass through said plurality of apertures in said first female strap in a flexed condition; and a second male strap extending substantially transversely from said base at a position longitudinally spaced from said first male strap, said second male strap having a length extending from a fixed end carried on a side of said base to a free end and carrying a plurality of flexible locking members along said length of said second male strap, said locking members being of a size to pass through said plurality of apertures in said second female strap in a flexed condition; and wherein the first and second male strap fixed ends are coupled with the base along a lateral side of said platform upper surface, said first female and male straps being flexible to move toward each other and said second female and male straps being flexible to move toward each other whereby said locking members carried on said first and second male straps can be inserted in selected ones of said apertures in said first and second female straps, respectively, and pulled to grip a tube and hold the tube along said length of said base, said base, said first and second female straps and said first and second male straps being unitarily, integrally formed together of a one-piece soft, low durometer elastomer having a hardness less than or equal to 30 Shore A; and wherein said first and second female straps and said first and second male straps join each other at their fixed ends providing a trough with a bottom for receiving and gripping tubes; and wherein each of said fixed ends of said first and second male straps is carried on a side of said platform upper surface at a position laterally opposite one of said first or second female straps and each of said first and second male straps has a free end spaced from said platform upper surface and an arcuate body between said fixed end and said free end to form a tube gripping curvature when said free ends of said first and second male straps are each received in one of said apertures in the opposing one of said first or second female straps.