A composition comprising a compound having a structure of: (a) Formula IV, or a salt thereof, wherein Formula IV is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, or methoxyethoxy; wherein R3 is selected from: -CH3, and -CH2CH2-O-CH3; wherein X1 is selected from: N, and CH; and wherein X2 is selected from: NH, O, S, and CH2; or (b) Formula V, or a salt thereof, wherein Formula V is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein R3 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2; or (c) Formula VI, or a salt thereof, wherein Formula VI is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2. (a) Formula IV, or a salt thereof, wherein Formula IV is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, or methoxyethoxy; wherein R3 is selected from: -CH3, and -CH2CH2-O-CH3; wherein X1 is selected from: N, and CH; and wherein X2 is selected from: NH, O, S, and CH2; or wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, or methoxyethoxy; wherein R3 is selected from: -CH3, and -CH2CH2-O-CH3; wherein X1 is selected from: N, and CH; and wherein X2 is selected from: NH, O, S, and CH2; or (b) Formula V, or a salt thereof, wherein Formula V is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein R3 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2; or wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein R2 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein R3 is selected from: hydrogen, methoxy, and methoxyethoxy; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2; or (c) Formula VI, or a salt thereof, wherein Formula VI is: wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2. wherein R1 is selected from: 2-methoxyethoxy, 2-ethoxyethoxy, 2-morpholinoethoxy, ethynyl, 2-(2-hydroxyethoxy)ethoxy, -O-CH2CH2CH2OH, -O-CH2CH2-NO2, -O-CH2CH2COOH, -O-CH2CH2-CONH2, -O-CH2CH2-O-CH2OH, -O-CH2CH2-O-CH2CN, - O-CH2CH2-O-CH2NH2, -O-CH2CH2-O-CH2NO2, -O-CH2CH2-O-CH2COOH, -O-CH2CH2-O-CH2CF3, and -O-CH2CH2-O-CH2CONH2; wherein X1 is N or CH; and wherein X2 is selected from: NH, O, S, and CH2.