An indexed drug containment device for an indexed drug actuation device for use in an indexed drug delivery and regulation device, the indexed drug containment device comprising: a valve assembly comprising a housing and a valve, the valve disposed within the housing, a gas canister in fluid communication with the valve, the canister containing an active pharmaceutical ingredient and an inactive gas carrier, the canister being aligned along a longitudinal axis, the valve being axially actuatable along the longitudinal axis, a first indexed member integral to the housing and a third indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member integral to a collar of the indexed drug actuation device, the second indexed member being a first key, the third indexed member adapted to be complementary to a fourth indexed member integral to the collar of the indexed drug actuation device, the fourth indexed member being a second key, wherein the first indexed member is non-complementary to the fourth indexed member, and wherein the third indexed member is non-complementary to the second indexed member, wherein the first indexed member is a first opening disposed on one side of the housing and the third indexed member is a second opening disposed on an opposite side of the housing with respect to the longitudinal axis of the gas canister, wherein the housing is engageable by the collar of the indexed drug actuation device in a direction perpendicular to the longitudinal axis, wherein one or more of the first and third indexed members are predeterminately adapted to indicate the identity of the active pharmaceutical ingredient, wherein indexing features that correspond to the identity of the active pharmaceutical ingredient are provided by one or more of different axial widths, axial juxtaposition, or different cross-sectional shapes of interfaces such that the indexed collar engages only the indexed drug containment device, whereby the indexing provides fully complementary members identified for the predetermined active pharmaceutical ingredient and/or dosing concentration. a valve assembly comprising a housing and a valve, the valve disposed within the housing, a gas canister in fluid communication with the valve, the canister containing an active pharmaceutical ingredient and an inactive gas carrier, the canister being aligned along a longitudinal axis, the valve being axially actuatable along the longitudinal axis, a first indexed member integral to the housing and a third indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member integral to a collar of the indexed drug actuation device, the second indexed member being a first key, the third indexed member adapted to be complementary to a fourth indexed member integral to the collar of the indexed drug actuation device, the fourth indexed member being a second key, wherein the first indexed member is non-complementary to the fourth indexed member, and wherein the third indexed member is non-complementary to the second indexed member, wherein the first indexed member is a first opening disposed on one side of the housing and the third indexed member is a second opening disposed on an opposite side of the housing with respect to the longitudinal axis of the gas canister, wherein the housing is engageable by the collar of the indexed drug actuation device in a direction perpendicular to the longitudinal axis, wherein one or more of the first and third indexed members are predeterminately adapted to indicate the identity of the active pharmaceutical ingredient, wherein indexing features that correspond to the identity of the active pharmaceutical ingredient are provided by one or more of different axial widths, axial juxtaposition, or different cross-sectional shapes of interfaces such that the indexed collar engages only the indexed drug containment device, whereby the indexing provides fully complementary members identified for the predetermined active pharmaceutical ingredient and/or dosing concentration.