mhurhangee/ep-ind-claims huggingface dataset:
A compound of Formula (I'): or a pharmaceutically acceptable salt or a stereoisomer thereof, for use in a method of treating a disease or disorder associated with inhibition of PD-1/PD-L1 interaction, wherein: ring A is azetidinyl, pyrrolidinyl or piperidinyl; X 1 is N; R 1 is methyl or halo; R 2 is C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-2 alkyl-, OH, NH 2, -NH-C 1-4 alkyl, -N(C 1-4 alkyl) 2, 4- to 6-membered heterocycloalkyl or 4- to 6-membered heterocycloalkyl-C 1-2 alkyl-, wherein the 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- each has one or two heteroatoms as ring members selected from O and N, and wherein the C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-2 alkyl-, - NH-C 1-4 alkyl, -N(C 1-4 alkyl) 2, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- of R 2 are each optionally substituted with 1 or 2 substituents independently selected from halo, CN and OH; R 3 is selected from -3-hydroxy-3-methylpyrrolidin-1-yl, -3-hydroxy-3-methylpyrrolidin-1-yl, -3-hydroxypyrrolidin-1-yl, -3-hydroxypyrrolidin-1-yl, -2-hydroxy-2-methyl-ethylamino, -2-hydroxy-2-methyl-ethylamino, -2-hydroxy-1-methyl-ethylamino and -2-hydroxy-1-methyl-ethylamino; R 4 is H or C 1-3 alkyl; and R 5 is C OH, C N(CH 3) 2, C NH(CH 3), or C NH(CH 2) 2 C OH. ring A is azetidinyl, pyrrolidinyl or piperidinyl; X 1 is N; R 1 is methyl or halo; R 2 is C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-2 alkyl-, OH, NH 2, -NH-C 1-4 alkyl, -N(C 1-4 alkyl) 2, 4- to 6-membered heterocycloalkyl or 4- to 6-membered heterocycloalkyl-C 1-2 alkyl-, wherein the 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- each has one or two heteroatoms as ring members selected from O and N, and wherein the C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-2 alkyl-, - NH-C 1-4 alkyl, -N(C 1-4 alkyl) 2, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C 1-2 alkyl- of R 2 are each optionally substituted with 1 or 2 substituents independently selected from halo, CN and OH; R 3 is selected from -3-hydroxy-3-methylpyrrolidin-1-yl, -3-hydroxy-3-methylpyrrolidin-1-yl, -3-hydroxypyrrolidin-1-yl, -3-hydroxypyrrolidin-1-yl, -2-hydroxy-2-methyl-ethylamino, -2-hydroxy-2-methyl-ethylamino, -2-hydroxy-1-methyl-ethylamino and -2-hydroxy-1-methyl-ethylamino; R 4 is H or C 1-3 alkyl; and R 5 is C OH, C N(CH 3) 2, C NH(CH 3), or C NH(CH 2) 2 C OH.
A fixation bracket adapted to mount a circuit board thereon, comprising: a pair of longitudinal beams and a pair of end plates, the pair of longitudinal beams extending in a length direction of the fixation bracket, the pair of end plates being connected to ends of the pair of longitudinal beams, respectively; an elastic snapping structure formed on a bottom of each end plate and engageable with a guide rail, the elastic snapping structure comprising: a pair of snapping slots (121, 122) adapted to be engaged with edges (321, 322) in both sides of the guide rail and an elastic arm, in which one of the pair of snapping slots (121, 122) is formed; and a connection arm (124,125,126) connected to the elastic snapping structure, a part of the connection arm being located above the longitudinal beams and end plates, wherein the elastic snapping structure is constructed to move away from the guide rail such that the elastic snapping structure is detachable from the guide rail when the connection arm is pulled by the part of the connection arm located above the longitudinal beams and end plates, and wherein the elastic snapping structure, the connection arm and the end plates are integrally formed. a pair of longitudinal beams and a pair of end plates, the pair of longitudinal beams extending in a length direction of the fixation bracket, the pair of end plates being connected to ends of the pair of longitudinal beams, respectively; an elastic snapping structure formed on a bottom of each end plate and engageable with a guide rail, the elastic snapping structure comprising: a pair of snapping slots (121, 122) adapted to be engaged with edges (321, 322) in both sides of the guide rail and an elastic arm, in which one of the pair of snapping slots (121, 122) is formed; and a connection arm (124,125,126) connected to the elastic snapping structure, a part of the connection arm being located above the longitudinal beams and end plates, wherein the elastic snapping structure is constructed to move away from the guide rail such that the elastic snapping structure is detachable from the guide rail when the connection arm is pulled by the part of the connection arm located above the longitudinal beams and end plates, and wherein the elastic snapping structure, the connection arm and the end plates are integrally formed. a pair of snapping slots (121, 122) adapted to be engaged with edges (321, 322) in both sides of the guide rail and an elastic arm, in which one of the pair of snapping slots (121, 122) is formed; and a connection arm (124,125,126) connected to the elastic snapping structure, a part of the connection arm being located above the longitudinal beams and end plates, wherein the elastic snapping structure is constructed to move away from the guide rail such that the elastic snapping structure is detachable from the guide rail when the connection arm is pulled by the part of the connection arm located above the longitudinal beams and end plates, and wherein the elastic snapping structure, the connection arm and the end plates are integrally formed.
A recombinant PtIP-50 polypeptide, wherein the amino acid sequence of the PtIP-50 polypeptide has: a) at least 80% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Aa as shown in Figures 10a-10o; b) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Aa, PtIP-50Ba, PtIP-50Bb, PtIP-50Bc, or PtIP-50Bd as shown in Figures 10a-100; c) at least 70% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fb, PtIP-50Fs, PtIP-50Fo, PtIP-50Fk, PtIP-50Fe, PtIP-50FI, PtIP-50Fn, or PtIP-50Ft as shown in Figures 10a-10o; d) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fd, PtIP-50Fm, PtIP-50Fr, PtIP-50Fg, or PtIP-50Fh as shown in Figures 10a-10o; e) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Ga, PtIP-50Gb, PtIP-50Gc, or PtIP-50Gd as shown in Figures 10a-10o; or f) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fa, PtIP-50Ff, PtIP-50Fq, PtIP-50Fi, or PtIP-50Fj as shown in Figures 10a-10o; wherein the PtIP-50 polypeptide has insecticidal activity in combination with a PtIP-65 polypeptide as defined in claim 3. a) at least 80% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Aa as shown in Figures 10a-10o; b) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Aa, PtIP-50Ba, PtIP-50Bb, PtIP-50Bc, or PtIP-50Bd as shown in Figures 10a-100; c) at least 70% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fb, PtIP-50Fs, PtIP-50Fo, PtIP-50Fk, PtIP-50Fe, PtIP-50FI, PtIP-50Fn, or PtIP-50Ft as shown in Figures 10a-10o; d) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fd, PtIP-50Fm, PtIP-50Fr, PtIP-50Fg, or PtIP-50Fh as shown in Figures 10a-10o; e) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Ga, PtIP-50Gb, PtIP-50Gc, or PtIP-50Gd as shown in Figures 10a-10o; or f) at least 75% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence PtIP-50Fa, PtIP-50Ff, PtIP-50Fq, PtIP-50Fi, or PtIP-50Fj as shown in Figures 10a-10o;
A white light lighting system (1, 25) comprising: at least one LED operable to generate and radiate blue excitation light of wavelength in a range 420nm to 470nm; an optical enclosure located remotely to the at least one LED and configured to at least in part enclose the at least one LED, wherein the optical enclosure in conjunction with at least one light reflective surface defines a closed volume housing the at least one LED and wherein the optical enclosure is configured such that blue excitation light travels in free-space a distance of at least one centimeter from the at least one LED to the optical enclosure; and at least one phosphor which is incorporated in a light translucent flexible sheet and the sheet inserted inside the optical enclosure, or is incorporated within and dispersed throughout the optical enclosure; wherein the phosphor emits light of a different wavelength in response to incident blue excitation light, wherein the emission product of the lighting system appears white in color to the eye and comprises the combined light from the at least one LED and the phosphor, wherein to ensure the emission product is only emitted from the optical enclosure.
A method for detecting, recording, analyzing, classifying and storing data of cranial vasculature of a patient, including the steps of: (a) using an array of accelerometers (S 1 - S 4) engaged at a plurality of different positions against a patient's head, recording pressure wave/motion stimulation acceleration signal data from displacements of the skull at said plurality of positions on the head, such displacements occurring from heartbeat-induced repeated pulsing of blood flow into the vasculature of the brain and resultant expansion and subsequent contraction of the blood vessels which moves the brain tissue due to such pulsing, the brain tissue movement causing resultant displacement of the skull at said plurality of positions on the head, and (b) associating signal signatures of said signal data to known signals for type classification using a neural network, or correlations, with information from a data store, wherein said known signals comprise signatures of a restricted vessel or aneurism. (a) using an array of accelerometers (S 1 - S 4) engaged at a plurality of different positions against a patient's head, recording pressure wave/motion stimulation acceleration signal data from displacements of the skull at said plurality of positions on the head, such displacements occurring from heartbeat-induced repeated pulsing of blood flow into the vasculature of the brain and resultant expansion and subsequent contraction of the blood vessels which moves the brain tissue due to such pulsing, the brain tissue movement causing resultant displacement of the skull at said plurality of positions on the head, and (b) associating signal signatures of said signal data to known signals for type classification using a neural network, or correlations, with information from a data store, wherein said known signals comprise signatures of a restricted vessel or aneurism.
A cell comprising a heterologous ω-3 desaturase capable of converting ω-6 docosapentaenoic acid into docosahexaenoic acid and having at least 75% identity to any of the amino acid sequences according to SEQ ID NO: 2 or 24.
A method of reproducing data from an optical disc comprising a lead-in area, which comprises a read only area and a write/read data area, the optical disc further comprising a user data area in which user data is recorded, characterised by the method comprising: reproducing first data from a first wobble formed in the read only area of the lead-in area; reproducing second data from a second wobble formed in the write/read data area, of the lead-in area; wherein the first wobble is modulated by a first modulation method and the second wobble is modulated by a second modulation method different to the first modulation method and the first wobble has a relatively high frequency compared to the second wobble. reproducing first data from a first wobble formed in the read only area of the lead-in area; reproducing second data from a second wobble formed in the write/read data area, of the lead-in area; wherein the first wobble is modulated by a first modulation method and the second wobble is modulated by a second modulation method different to the first modulation method and the first wobble has a relatively high frequency compared to the second wobble.
A modular tool comprising a tool holder, said tool holder being provided with an entry aperture, and adapted to receive a proximal extremity of a tool element in said entry aperture, said modular tool further comprising a securing pin assembly comprising a securing pin, said tool holder further comprising a securing pin channel extending though said tool holder and terminating in said entry aperture, said securing pin being situated in said securing channel so as to slidingly move between a first, retracted position and a second, extended position in which said securing pin protrudes into said entry aperture, whereby in said second position said securing pin traps said proximal extremity of said tool element in said entry aperture, said proximal extremity being unconstrained by said securing pin in said first position, said modular tool further comprising a rocker element (230, 430) having a fulcrum pivotally coupled to said tool holder, a first arm on one side of said fulcrum pivotally coupled to said securing pin, and a second arm on the opposite side of said fulcrum to said first arm, such that either a. pressure brought to bear by a user's thumb on said first arm biases said securing pin towards said first position, and pressure brought to bear by a user's thumb on said second arm biases said securing pin towards said second position, or b. pressure brought to bear by a user's thumb on said first arm biases said securing pin towards said second position, and pressure brought to bear by a user's thumb on said second arm biases said securing pin towards said first position. a. pressure brought to bear by a user's thumb on said first arm biases said securing pin towards said first position, and pressure brought to bear by a user's thumb on said second arm biases said securing pin towards said second position, or b. pressure brought to bear by a user's thumb on said first arm biases said securing pin towards said second position, and pressure brought to bear by a user's thumb on said second arm biases said securing pin towards said first position.
A system for digitizing components of a vehicle, the system comprising: a 3-dimensional sensing system operatively arranged to monitor a human-machine interface component including an operator engageable component of the vehicle, the operator engageable component for controlling a controlled device of the vehicle, the 3-dimensional sensing system including at least one remote sensing device capable of detecting a position or status of the human-machine interface component; and a controller arranged to receive sensed data from the 3-dimensional sensing system; wherein the controller processes the sensed data to assign a digital value that is used to recognize the position or status of the human-machine interface component and corresponds to a directed condition of the controlled device and outputs a signal indicative of a condition of the human-machine interface component, the controlled device controlled by the condition of the human-machine interface component. a 3-dimensional sensing system operatively arranged to monitor a human-machine interface component including an operator engageable component of the vehicle, the operator engageable component for controlling a controlled device of the vehicle, the 3-dimensional sensing system including at least one remote sensing device capable of detecting a position or status of the human-machine interface component; and a controller arranged to receive sensed data from the 3-dimensional sensing system; wherein the controller processes the sensed data to assign a digital value that is used to recognize the position or status of the human-machine interface component and corresponds to a directed condition of the controlled device and outputs a signal indicative of a condition of the human-machine interface component, the controlled device controlled by the condition of the human-machine interface component.
A two-stage prosthetic heart valve, comprising: an expandable anchoring member sized to contact a heart valve annulus in an expanded state, wherein the anchoring member comprises a stent, and wherein the stent is provided with a bottom portion and an upper flared portion wherein the two-stage prosthetic heart valve further comprises a non-expandable valve member configured for connection to the anchoring member, wherein the valve member comprises a base ring surrounding an inflow end thereof, the base ring being sized to fit with the upper flared portion and wherein a plurality of tines is disposed along a top end of the flared portion made of a shape memory material that change shape and engage the base ring by curling inwardly upon reaching a certain temperature. an expandable anchoring member sized to contact a heart valve annulus in an expanded state, wherein the anchoring member comprises a stent, and wherein the stent is provided with a bottom portion and an upper flared portion wherein the two-stage prosthetic heart valve further comprises a non-expandable valve member configured for connection to the anchoring member, wherein the valve member comprises a base ring surrounding an inflow end thereof, the base ring being sized to fit with the upper flared portion and wherein a plurality of tines is disposed along a top end of the flared portion made of a shape memory material that change shape and engage the base ring by curling inwardly upon reaching a certain temperature.
Method for controlling the volume generated by a loudspeaker in a cabin containing passengers, characterized in that it comprises: - a first step of acquiring sound (Sb) in the cabin, - a second step of filtering by cancellation from the sound (Sb) acquired in the first step the sound (Sg) generated by the loudspeaker, - a third step of classifying a cabin sound situation (Css) based on the sound (Sn) filtered in the second step, - a fourth step of determining a visual communication intensity (Icv) in the cabin, said visual communication intensity (Icv) being representative of a frequency with which the passengers of the cabin look at one another, - a fifth step of controlling the volume generated by the loudspeaker depending on the sound situation (Css) classified in the third step and on the visual communication intensity (Icv) determined in the fourth step. - a first step of acquiring sound (Sb) in the cabin, - a second step of filtering by cancellation from the sound (Sb) acquired in the first step the sound (Sg) generated by the loudspeaker, - a third step of classifying a cabin sound situation (Css) based on the sound (Sn) filtered in the second step, - a fourth step of determining a visual communication intensity (Icv) in the cabin, said visual communication intensity (Icv) being representative of a frequency with which the passengers of the cabin look at one another, - a fifth step of controlling the volume generated by the loudspeaker depending on the sound situation (Css) classified in the third step and on the visual communication intensity (Icv) determined in the fourth step.
A water-dispersed pressure-sensitive adhesive composition, which comprises: a (meth)acrylic polymer obtained by polymerizing monomer ingredient(s) including as a main component a (meth)acrylic acid alkyl ester in which the alkyl group has 1-18 carbon atoms, the content of said (meth)acrylic acid alkyl ester being 60% by weight or more of all monomers of the monomer ingredients, a rubber ingredient which is incompatible with the (meth)acrylic polymer as determined by observing whether the loss modulus curve or the loss tangent curve obtained by a dynamic viscoelasticity examination has two peaks assigned to the rubber ingredient and to the (meth)acrylic polymer, respectively, and which has a degree of swelling of 130% or higher upon immersion for 2 hours in a mineral-oil-based rust preventive oil having a kinetic viscosity at 40°C of 5 mm 2 /s, and a tackifier, wherein a blending ratio by weight of the (meth)acrylic polymer to the rubber ingredient is from 95/5 to 5/95, and wherein the tackifier contains at least a tackifier having a softening point of 120°C or higher. a (meth)acrylic polymer obtained by polymerizing monomer ingredient(s) including as a main component a (meth)acrylic acid alkyl ester in which the alkyl group has 1-18 carbon atoms, the content of said (meth)acrylic acid alkyl ester being 60% by weight or more of all monomers of the monomer ingredients, a rubber ingredient which is incompatible with the (meth)acrylic polymer as determined by observing whether the loss modulus curve or the loss tangent curve obtained by a dynamic viscoelasticity examination has two peaks assigned to the rubber ingredient and to the (meth)acrylic polymer, respectively, and which has a degree of swelling of 130% or higher upon immersion for 2 hours in a mineral-oil-based rust preventive oil having a kinetic viscosity at 40°C of 5 mm 2 /s, and a tackifier,
Method for the stereoselective preparation of the compound of formula, optionally in the form of the tautomers thereof, wherein SG 1 denotes a protective group selected from among trifluoroacetyl, acetyl, benzoyl and pivaloyl, SG 2 denotes a protective group selected from among tert.-butoxycarbonyl, ethoxycarbonyl and methoxycarbonyl, characterised in that the method comprises reaction steps and, where denotes the reaction of the compound of formula to form a compound of formula and denotes the reduction of the compound of formula to form a compound of formula, wherein process steps and are carried out successively in the order stated. denotes the reaction of the compound of formula to form a compound of formula and denotes the reduction of the compound of formula to form a compound of formula, wherein process steps and are carried out successively in the order stated.