A clamping device for an external fixation system, comprising: a clamp body and a locking assembly (404, 406), the clamp body including a first jaw and a second jaw, the first jaw and second jaw defining a slot extending between a first surface of the first jaw and a second surface of the second jaw and in communication with a first channel, the first channel configured to accommodate a first fixation element along a first longitudinal axis of the first channel, the first jaw defining a first opening and the second jaw defining a second opening that are sized to receive a portion of the locking assembly (404, 406), the first opening and the second opening defining a second longitudinal axis passing through the first opening and the second opening; the locking assembly including a first fastening element configured to pass through the first opening and the second opening when a third longitudinal axis of the first fastening element is aligned with the second longitudinal axis, the first fastening element defining a second channel configured to accommodate a bone pin for insertion into a bone of a subject, the locking assembly including a second fastening element configured to engage with the first fastening element, wherein the locking assembly is configured to restrict movement of the first fixation element relative to the clamp body and restrict movement of the bone pin relative to the clamp body in response to tightening of the locking assembly (404, 406); wherein the second jaw further defines at least one recess of the second opening and the first fastening element includes at least one protrusion, the at least one recess configured to: receive the at least one protrusion to prevent rotation of the first fastening element relative to the second jaw; and prevent the at least one protrusion from being received by the at least one recess when the at least one protrusion is not aligned with the at least one recess. a clamp body and a locking assembly (404, 406), the clamp body including a first jaw and a second jaw, the first jaw and second jaw defining a slot extending between a first surface of the first jaw and a second surface of the second jaw and in communication with a first channel, the first channel configured to accommodate a first fixation element along a first longitudinal axis of the first channel, the first jaw defining a first opening and the second jaw defining a second opening that are sized to receive a portion of the locking assembly (404, 406), the first opening and the second opening defining a second longitudinal axis passing through the first opening and the second opening; the locking assembly including a first fastening element configured to pass through the first opening and the second opening when a third longitudinal axis of the first fastening element is aligned with the second longitudinal axis, the first fastening element defining a second channel configured to accommodate a bone pin for insertion into a bone of a subject, the locking assembly including a second fastening element configured to engage with the first fastening element, wherein the locking assembly is configured to restrict movement of the first fixation element relative to the clamp body and restrict movement of the bone pin relative to the clamp body in response to tightening of the locking assembly (404, 406); wherein the second jaw further defines at least one recess of the second opening and the first fastening element includes at least one protrusion, the at least one recess configured to: receive the at least one protrusion to prevent rotation of the first fastening element relative to the second jaw; and prevent the at least one protrusion from being received by the at least one recess when the at least one protrusion is not aligned with the at least one recess. receive the at least one protrusion to prevent rotation of the first fastening element relative to the second jaw; and prevent the at least one protrusion from being received by the at least one recess when the at least one protrusion is not aligned with the at least one recess.