An endosurgical operating device 100 comprising: an operation tube 111 configured to be installed in an insertion part 5 of an endoscope 1 to be inserted in a body; an operation plate 122 which is installed in the operation tube 111 and includes, at least one needle 121 provided with a pointed tip or at least one protrusion 800 provided with a pointed tip; a driving unit 165 configured to drive the operation plate 122 so that, at least one of the needles or the pointed tip of at least one protrusion 800, passes through an end portion of the operation tube 111, and is inserted into an internal tissue surface or an epithelium surface in the body; and a power supply unit 140 which is electrically connected to, the at least one needle 121 or the at least one protrusion 800; and an adsorption means 170 which is provided in the end portion of the operation tube 111, wherein the adsorption means 170 has an adsorption means body 171 in which an air flow space 172 is formed; an air flow means creating an air flow from an inlet to an outlet of the air flow space, at least one adsorption hole 174, which communicates with the air flow space 172, is formed in the adsorption means body 171, a diameter of the adsorption hole 174 is bigger than a cross-section of the needle 121 perpendicular to a longitudinal direction of the needle 121, and wherein the flow of air generated in the air flow space 172 by operation of the air flow means decreases the pressure in the air flow space 172 to adhere the tissue surface or epithelium surface to the adsorption means and to absorb substances discharged from the tissue surface or the epithelium surface into the endosurgical operating device through the adsorption hole, when the at least one needle 121 is inserted into the at least one adsorption hole 174 and the internal tissue surface or the epithelium surface in the body, the endosurgical operating device further comprises a filtration means which filters the absorbed substances. an operation tube 111 configured to be installed in an insertion part 5 of an endoscope 1 to be inserted in a body; an operation plate 122 which is installed in the operation tube 111 and includes, at least one needle 121 provided with a pointed tip or at least one protrusion 800 provided with a pointed tip; a driving unit 165 configured to drive the operation plate 122 so that, at least one of the needles or the pointed tip of at least one protrusion 800, passes through an end portion of the operation tube 111, and is inserted into an internal tissue surface or an epithelium surface in the body; and a power supply unit 140 which is electrically connected to, the at least one needle 121 or the at least one protrusion 800; and an adsorption means 170 which is provided in the end portion of the operation tube 111, wherein the adsorption means 170 has an adsorption means body 171 in which an air flow space 172 is formed; an air flow means creating an air flow from an inlet to an outlet of the air flow space, at least one adsorption hole 174, which communicates with the air flow space 172, is formed in the adsorption means body 171, a diameter of the adsorption hole 174 is bigger than a cross-section of the needle 121 perpendicular to a longitudinal direction of the needle 121, and wherein the flow of air generated in the air flow space 172 by operation of the air flow means decreases the pressure in the air flow space 172 to adhere the tissue surface or epithelium surface to the adsorption means and to absorb substances discharged from the tissue surface or the epithelium surface into the endosurgical operating device through the adsorption hole, when the at least one needle 121 is inserted into the at least one adsorption hole 174 and the internal tissue surface or the epithelium surface in the body, the endosurgical operating device further comprises a filtration means which filters the absorbed substances.