A chromatography cartridge comprising: a barrel arranged to be at least at one end sealed with a cap and a seal member, wherein: - the barrel comprises a thread arranged on the outer cylindrical surface of the barrel, a barrel seal surface extending radially on the end surface of the barrel and a circumferential barrel lip provided on the barrel seal surface and extending in the longitudinal direction; - the cap comprises an outer cylindrical part which on its inner surface comprises a thread arranged to mate with the thread of the barrel, a radially extending top, an intermediate part joining the outer cylindrical part with the radially extending top and an inner cylindrical part, a seal holder provided between the outer surface of the inner cylindrical part and an inner surface of the intermediate part, a cap seal surface arranged between the seal holder and the inner surface of the intermediate part; and - the seal member is provided in a space formed by the seal holder, the inner surface of the intermediate part and the cap seal surface; and wherein: the intermediate part of the cap on its inner surface comprises a contact surface, and the cap being mounted on the barrel, the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member, the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder, the cap seal surface and the inside of the barrel lip, forming a second cartridge seal. - the barrel comprises a thread arranged on the outer cylindrical surface of the barrel, a barrel seal surface extending radially on the end surface of the barrel and a circumferential barrel lip provided on the barrel seal surface and extending in the longitudinal direction; - the cap comprises an outer cylindrical part which on its inner surface comprises a thread arranged to mate with the thread of the barrel, a radially extending top, an intermediate part joining the outer cylindrical part with the radially extending top and an inner cylindrical part, a seal holder provided between the outer surface of the inner cylindrical part and an inner surface of the intermediate part, a cap seal surface arranged between the seal holder and the inner surface of the intermediate part; and - the seal member is provided in a space formed by the seal holder, the inner surface of the intermediate part and the cap seal surface; and wherein: the intermediate part of the cap on its inner surface comprises a contact surface, and the cap being mounted on the barrel, the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member, the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder, the cap seal surface and the inside of the barrel lip, forming a second cartridge seal. the intermediate part of the cap on its inner surface comprises a contact surface, and the cap being mounted on the barrel, the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member, the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder, the cap seal surface and the inside of the barrel lip, forming a second cartridge seal.