A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: L 1 is -CH 2 - or -CH 2 CH 2 -, and R 20 is substituted or unsubstituted phenyl; R 1 is hydrogen, halogen, -CN, -NO 2, -NR 1B R 1C, NR 1B C R 1D, -C OR 1D or substituted or unsubstituted alkyl; R 2 is hydrogen, F, Br, I, -CN, -NO 2, -NR 2B R 2C, NR 2B C R 2D, -C OR 2D or substituted or unsubstituted alkyl; R 3 is hydrogen, halogen, -CN, -NO 2, -NR 3B R 3C, NR 3B C R 3D, -C OR 3D or substituted or unsubstituted alkyl; R 4 is hydrogen, halogen, -CN, -NO 2, -NR 4B R 4C, NR 4B C R 4D, -C OR 4D or substituted or unsubstituted alkyl; R 5 is hydrogen, halogen, -CN, -NO 2, -NR 5B R 5C, NR 5B C R 5D, -C OR 5D or substituted or unsubstituted alkyl; wherein at least two of R 1, R 2, R 3, R 4, R 5 are hydrogen; or wherein R 1 and R 2, R 2 and R 3, R 3 and R 4, or R 1 and R 5 are optionally joined to form, together with the atoms to which they are attached, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen; R 1A, R 1B, R 1C, R 1D, R 2A, R 2B, R 2C, R 2D, R 3A, R 3B,R 3C, R 3D, R 4A, R 4B, R 4C, R 4D, R 5A, R 5B, R 5C, and R 5D, are independently hydrogen, halogen, -CF 3, -CCl 3, -CBr 3, -CI 3, -OH, -NH 2, - COOH, -CONH 2, -NO 2, -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3, -OCCl 3, -OCBr 3, -OCI 3, -OCHF 2, -OCHCl 2, -OCHBr 2, -OCHI 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1B, R 1C, R 2B, R 2C, R 3B, R 3C R 4B, R 4C, R 5B, R 5C, substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and X 1.1, X 2.1, X 3.1, X 4.1, X 5.1, are independently -Cl, -Br, -I or -F, with proviso that when L 1 is -CH 2 -, and R 3 is -NO 2, then R 5 is not -NH 2, or when L 1 is - CH 2 -, and R 1 is -NO 2, then R 4 is not NH 2, with proviso that when L 1 is a -CH 2 - and R 20 is unsubstituted phenyl, then at least one of R 1, R 2, R 3, R 4 and R 5 is halogen, NO 2, NH 2, COOCH 3, COOH, CN or substituted C 1 -C 3 alkyl or R 2 and R 3 is joined to form, together with the atoms to which they are attached, substituted or unsubstituted heteroaryl. L 1 is -CH 2 - or -CH 2 CH 2 -, and R 20 is substituted or unsubstituted phenyl; R 1 is hydrogen, halogen, -CN, -NO 2, -NR 1B R 1C, NR 1B C R 1D, -C OR 1D or substituted or unsubstituted alkyl; R 2 is hydrogen, F, Br, I, -CN, -NO 2, -NR 2B R 2C, NR 2B C R 2D, -C OR 2D or substituted or unsubstituted alkyl; R 3 is hydrogen, halogen, -CN, -NO 2, -NR 3B R 3C, NR 3B C R 3D, -C OR 3D or substituted or unsubstituted alkyl; R 4 is hydrogen, halogen, -CN, -NO 2, -NR 4B R 4C, NR 4B C R 4D, -C OR 4D or substituted or unsubstituted alkyl; R 5 is hydrogen, halogen, -CN, -NO 2, -NR 5B R 5C, NR 5B C R 5D, -C OR 5D or substituted or unsubstituted alkyl; wherein at least two of R 1, R 2, R 3, R 4, R 5 are hydrogen; or wherein R 1 and R 2, R 2 and R 3, R 3 and R 4, or R 1 and R 5 are optionally joined to form, together with the atoms to which they are attached, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 6 is hydrogen; R 7 is hydrogen; R 8 is hydrogen; R 9 is hydrogen; R 1A, R 1B, R 1C, R 1D, R 2A, R 2B, R 2C, R 2D, R 3A, R 3B,R 3C, R 3D, R 4A, R 4B, R 4C, R 4D, R 5A, R 5B, R 5C, and R 5D, are independently hydrogen, halogen, -CF 3, -CCl 3, -CBr 3, -CI 3, -OH, -NH 2, - COOH, -CONH 2, -NO 2, -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2, -NHNH 2, -ONH 2, -NHC NHNH 2, -NHC NH 2, -NHSO 2 H, -NHC H, -NHC -OH, -NHOH, -OCF 3, -OCCl 3, -OCBr 3, -OCI 3, -OCHF 2, -OCHCl 2, -OCHBr 2, -OCHI 2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1B, R 1C, R 2B, R 2C, R 3B, R 3C R 4B, R 4C, R 5B, R 5C, substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and X 1.1, X 2.1, X 3.1, X 4.1, X 5.1, are independently -Cl, -Br, -I or -F, with proviso that when L 1 is -CH 2 -, and R 3 is -NO 2, then R 5 is not -NH 2, or when L 1 is - CH 2 -, and R 1 is -NO 2, then R 4 is not NH 2, with proviso that when L 1 is a -CH 2 - and R 20 is unsubstituted phenyl, then at least one of R 1, R 2, R 3, R 4 and R 5 is halogen, NO 2, NH 2, COOCH 3, COOH, CN or substituted C 1 -C 3 alkyl or R 2 and R 3 is joined to form, together with the atoms to which they are attached, substituted or unsubstituted heteroaryl.