A Compound of formula their pharmaceutically acceptable salts and their stereoisomers, atropisomers, conformers, tautomers, polymorphs, hydrates, solvates and N-oxide; wherein, X is selected from O, S n, NH and N(C 1 -C 3)alkyl; R 1 and R 2 is independently selected from hydrogen, A, CHO, C=N-OH, C=N-O-(C 1 -C 6)alkyl, CH 2 OH, CH 2 R 3, N(R 5)CO 2 R 4, CH 2 -halogen, NR 5 R 6, N(R 5)C -A, N(R 5)S m -A, N(R 5)C N(R 5)-A, N(R 5)C N(R 5)-A, C NR 5 R 6, CO 2 R 7, C -A, CH -A C(CH 3)=N-OH, C(CH 3)=N-O-(C 1 -C 6)alkyl, C CH 2 -halogen and C CH 2 R 3; R is independently selected from hydrogen, (C 1 -C 6)alkyl, (C 3 -C 10)carbocycle, CN, CHO, C -A, C(CH 3)=N-OH, C(CH 3)=N-O-(C 1 -C 6)alkyl, C CH 2 -halogen, C CH 2 R 3, NR 5 R 6, N(R 5)C -A, N(R 5)S m -A, N(R 5)C O-A, N(R 5)C N(R 5)-A, N(R 5)C N(R 5)-A, CO 2 R 7, C N(R 5)-A, (C 1 -C 6)alkyl-OR 7, (C 1 -C 6)alkyl-halogen, (C 1 -C 6)alkyl-N 3, (C 1 -C 6)alkyl-NR 5 R 6, (C 1 -C 6)alkyl-N(R 5)C -A, (C 1 -C 6)alkyl-N(R 5)S m -A, (C 1 -C 6)alkyl-N(R 5)C O-A, (C 1 -C 6)alkyl-N(R 5)C N(R 5)-A, (C 1 -C 6)alkyl-N(R 5)C N(R 5)-A and (C 1 -C 6)alkyl-OC N(R 5)-A; A is independently selected from (C 1 -C 6)alkyl, (C 3 -C 10)carbocycle, aryl, heteroaryl and heterocyclic, the said (C 1 -C 6)alkyl, (C 3 -C 10)carbocycle, aryl, heteroaryl or heterocyclic may be optionally substituted with 1-3 substituents independently selected from halogen, (C 1 -C 6)alkyl, (C 3 -C 10)carbocycle, aryl, heteroaryl, heterocyclic, hydroxyl, CF 3, OCF 3, O(C 1 -C 6)alkyl, O-(C 3 -C 10)carbocycle, NO 2, C -(C 1 -C 6)alkyl, C CH 2 -halogen, C CH 2 R 3, NR 5 R 6, CO 2 R 7, C N(R 5)-A, N(R 5)S m -A, SH, S n (C 1 -C 6)alkyl, S m N(R 5)-A, CN, CHO, (C 1 -C 6)alkyl-OR 7, (C 1 -C 6)alkyl-halogen and (C 1 -C 6)alkyl-NR 5 R6 wherein each aryl or heteroaryl may be further optionally substituted with 1-3 substituents independently selected from halogen, (C 1 -C 6)alkyl, (C 3 -C 10)carbocycle, aryl, heteroaryl, heterocyclic, hydroxyl, CF 3, OCF 3, O(C 1 -C 6)alkyl, O-(C 3 -C 10)carbocycle, NO 2, C -(C 1 -C 6)alkyl, C CH 2 -halogen, C CH 2 R 3, NR 5 R 6, CO 2 R 7, C N(R 5)-A, N(R 5)S m -A, SH, S n (C 1 -C 6)alkyl, S m N(R 5)-A, CN, OSO 3 H, CHO, (C 1 -C 6)alkyl-OR 7, (C 1 -C 6)alkyl-halogen, (C 1 -C 6)alkyl-NR 5 R 6 and R 3 is independently selected from O-A, NR 5 R 6, S n -A, S n -(C 1 -C 6)alkyl-CO 2 (C 1 -C 6)alkyl, S n -(C 1 -C 6)alkyl-OH, S n -(C 1 -C 6)alkyl-CO 2 H, N(R 5)C -A, N(R 5)C O-A, N(R 5)C N(R 5)-A, N(R 5)S m -A, N(R 5)C -heterocyclic and N(R 5)C N(R 5)-A; R 4 is hydrogen or A; R 5 and R 5 ' is independently selected from hydrogen, (C 1 -C 6)alkyl, (C 1 -C 6)alkyl-(C 3 -C 10)carbocycle and (C 3 -C 10)carbocycle; R 6 and R 6 ' is independently selected from hydrogen, A, (C 1 -C 6)alkyl-OH, (C 1 -C 6)alkyl-NR 5 'R 6 ', CH(CH 2 OH)-aryl, CH(CH 2 OH) 2, (C 1 -C 6)alkyl-aryl, (C 1 -C 6)alkyl-heterocyclic and (C 1 -C 6)alkyl-heteroaryl; R 5 and R 6 or R 5 ' and R 6 ' together with the nitrogen to which they are attached may form a 3 to 8 membered monocyclic or 8 to 12 membered bicyclic heterocycle ring, which ring optionally contains an additional heteroatom selected from O, S or N and the said ring is optionally substituted by one or more Rg or R 10 substituent; the nitrogen of said ring may also form N-oxide; in bicyclic heterocyclic system, the rings can be attached to each other in a spiro or fused manner; R 7 is hydrogen or A; Each R 8 is independently 1-2 substituents and each selected from hydrogen, halogen, A, CN, CHO, C -A, C CH 2 -halogen, C CH 2 R 3, hydroxyl, CF 3, OCF 3, NR 5 R 6, N(R 5)C -A, N(R 5)S m -A, C N(R 5)-A, O-(C 1 -C 6)alkyl, O-(C 3 -C 10)carbocycle, S n -A and S m N(R 5)-A, wherein R and R 8 are simultaneously not hydrogen; Rg is independently selected from hydrogen, halogen, A, hydroxyl, CF 3, OCF 3, O(C 1 -C 6)alkyl, O-(C 3 -C 10)carbocycle, NO 2, C -A, C CH 2 -halogen, C CH 2 R 3, NR 5 R 6, N(R 5)C O-A, N(R 5)C N(R 5)-A, N(R 5)C N(R 5)-A, CO 2 R 7, C N(R 5)-A, CN, CHO, (C 1 -C 6)alkyl-OR 7, (C 1 -C 6)alkyl-halogen, (C 1 -C 6)alkyl-aryl, (C 1 -C 6)alkyl-NR 5 R 6, (C 1 -C 6)alkyl-N(R 5)C O-A, (C 1 -C 6)alkyl-N(R 5)C N(R 5)-A, (C 1 -C 6)alkyl-N(R 5)C N(R 5)-A, (C 1 -C 6)alkyl-OC N(R 5)-A and N(R 5)S m -A; R 10 is selected from hydrogen, halogen, A, hydroxyl, (C 1 -C 6)alkyl-(C 3 -C 10)carbocycle, (C 1 -C 6)alkyl-aryl, C -A, CO 2 R 7, C N(R 5)-A, C (C 1 -C 6)alkyl-A, oxo, thio, =N-OH, =N-O-(C 1 -C 6)alkyl, O-(C 1 -C 6)alkyl, O-(C 3 -C 10)carbocycle, O-aryl, O-heteroaryl, S n -A, NR 5 R 6, N(R 5)C -A, N(R 5)C O-A, N(R 5)C N(R 5)-A, N(R 5)S m -A, N(R 5)C -heterocyclic and N(R 5)C N(R 5)-A; m is 1 or 2; n is 0, 1 or 2.