A compound of Formula: or a pharmaceutically acceptable salt thereof; wherein: R 1 is substituted or unsubstituted aliphatic; R 2 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted cyclopropyl, or -OR A2, wherein R A2 is hydrogen or substituted or unsubstituted alkyl; R 3a is hydrogen or -OR A3, wherein R A3 is hydrogen or substituted or unsubstituted alkyl, and R 3b is hydrogen; or R 3a and R 3b are joined to form an oxo (=O) group; R 4 is hydrogen, substituted or unsubstituted alkyl, or halogen; X is -C(R X) 2 - or -O-, wherein R X is hydrogen or fluorine, or one R X group and R 5b are joined to form a double bond; each instance of R 5a and R 5b is independently hydrogen or fluorine; R 6a is a non-hydrogen group selected from the group consisting of substituted and unsubstituted alkyl, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted carbocyclyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl group, wherein the non-hydrogen group is optionally substituted with fluorine; and R 6b is hydrogen or a substituted or unsubstituted alkyl group optionally substituted with fluorine; ----- represents a single or double bond, provided if a single bond is present, then the hydrogen at C5 is in the alpha configuration; provided that: at least one of R X, R 5a, and R 5b is fluorine; or at least one of R 6a and R 6b is a non-hydrogen group substituted with a fluorine; or R 6a is a non-hydrogen group comprising between two and ten carbon atoms; and further provided that the compound is not: R 1 is substituted or unsubstituted aliphatic; R 2 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted cyclopropyl, or -OR A2, wherein R A2 is hydrogen or substituted or unsubstituted alkyl; R 3a is hydrogen or -OR A3, wherein R A3 is hydrogen or substituted or unsubstituted alkyl, and R 3b is hydrogen; or R 3a and R 3b are joined to form an oxo (=O) group; R 4 is hydrogen, substituted or unsubstituted alkyl, or halogen; X is -C(R X) 2 - or -O-, wherein R X is hydrogen or fluorine, or one R X group and R 5b are joined to form a double bond; each instance of R 5a and R 5b is independently hydrogen or fluorine; R 6a is a non-hydrogen group selected from the group consisting of substituted and unsubstituted alkyl, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted carbocyclyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl group, wherein the non-hydrogen group is optionally substituted with fluorine; and R 6b is hydrogen or a substituted or unsubstituted alkyl group optionally substituted with fluorine; ----- represents a single or double bond, provided if a single bond is present, then the hydrogen at C5 is in the alpha configuration; at least one of R X, R 5a, and R 5b is fluorine; or at least one of R 6a and R 6b is a non-hydrogen group substituted with a fluorine; or R 6a is a non-hydrogen group comprising between two and ten carbon atoms; and further provided that the compound is not: