An infusion control device for monitoring and setting the flow of an infusion fluid in an infusion system comprising: a) a housing defining a channel there through, an upper portion of the channel thereof being configured for accommodating at least a part of a drip chamber and a lower portion of the channel thereof being configured for accommodating at least a part of an infusion tubing; b) a clamping mechanism comprising at least one of a torsion spring, the clamping mechanism thereof being configured for engaging and holding the drip chamber within the upper portion and to be adjusted according to the diameter of the drip chamber; c) a drop sensor for detecting the drops falling through the drip chamber, the sensor thereof being disposed in the upper portion adjacent to the drip chamber; d) circuits disposed substantially within the housing, the circuit thereof being configured for processing the information received from the sensor for detecting real time drop rate of the infusion fluid; e) a flow regulation mechanism; and f) a power source disposed within the housing and configured for powering the drop sensor and the circuits; characterized in that: - the circuits are coupled with the drop sensor; and - the flow regulation mechanism is a manual flow regulation mechanism disposed substantially within the housing and comprising a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing. a) a housing defining a channel there through, an upper portion of the channel thereof being configured for accommodating at least a part of a drip chamber and a lower portion of the channel thereof being configured for accommodating at least a part of an infusion tubing; b) a clamping mechanism comprising at least one of a torsion spring, the clamping mechanism thereof being configured for engaging and holding the drip chamber within the upper portion and to be adjusted according to the diameter of the drip chamber; c) a drop sensor for detecting the drops falling through the drip chamber, the sensor thereof being disposed in the upper portion adjacent to the drip chamber; d) circuits disposed substantially within the housing, the circuit thereof being configured for processing the information received from the sensor for detecting real time drop rate of the infusion fluid; e) a flow regulation mechanism; and f) a power source disposed within the housing and configured for powering the drop sensor and the circuits; characterized in that: - the circuits are coupled with the drop sensor; and - the flow regulation mechanism is a manual flow regulation mechanism disposed substantially within the housing and comprising a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing. - the circuits are coupled with the drop sensor; and - the flow regulation mechanism is a manual flow regulation mechanism disposed substantially within the housing and comprising a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing.