A compound satisfying formula I, a prodrug, N -oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; wherein each X independently is C or N with at least one X being N; R 1 is present where X = C and R 1 selected from the group of H, OH, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, N(R 6) 2, CO(R 7), CH 2 NH 2, CH 2 OH, CN, C(=NOH)NH 2, C(=NOCH 3)NH 2, C(=NH)NH 2, CF 3, OCF 3, and B 2; B(O-C 1 -C 6 alkyl); R 2 is selected from the group consisting of H, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, and CO(R 7); R 3 is -(CR 8 R 9) n -R 10; R 4 is selected from the group consisting of H, C 1 -C 10 alkyl, CH 2 CF 3, C 3 -C 7 cycloalkyl, C 2 -C 10 alkenyl, SO 2 -R 8, or a 4 to 6 membered saturated ring containing an oxygen atom; R 5 is present where Y is C, and is selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, CO(R 7), CF 3 and halogen; R 5 is absent where X is N; R 6 is selected from the group consisting of H, C 1 -C 6 alkyl, COOCH 3, and CONHSO 2 CH 3; R 7 is selected from the group consisting of OH, O(C 1 -C 6 alkyl), NH 2, NHSO 2 N(C 1 -C 6 alkyl) 2, NHSO 2 NHCH 3, NHSO 2 (C 1 -C 6 alkyl), NHSO 2 (C 3 -C 7 cycloalkyl), and N(C 1 -C 6 -alkyl) 2; n is an integer from 2 to 6; R 8 and R 9 are each independently chosen from H, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl or R 8 and R 9 taken together form a 4 to 6 membered aliphatic ring that optionally contains a heteroatom selected from the group N, S, O; R 10 is selected from the group consisting of H, C 1 -C 6 alkyl, OH, CN, F, CF 2 H, CF 3, CONR 8 R 9, COOR 8, CONR 8 SO 2 R 9, CON(R 8)SO 2 N(R 8 R 9), NR 8 R 9, NR 8 COOR 9, OCOR 8, NR 8 SO 2 R 9, SO 2 NR 8 R 9, SO 2 R 8 or a 4 to 6 membered saturated ring containing an oxygen atom. wherein each X independently is C or N with at least one X being N; R 1 is present where X = C and R 1 selected from the group of H, OH, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, N(R 6) 2, CO(R 7), CH 2 NH 2, CH 2 OH, CN, C(=NOH)NH 2, C(=NOCH 3)NH 2, C(=NH)NH 2, CF 3, OCF 3, and B 2; B(O-C 1 -C 6 alkyl); R 2 is selected from the group consisting of H, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, and CO(R 7); R 3 is -(CR 8 R 9) n -R 10; R 4 is selected from the group consisting of H, C 1 -C 10 alkyl, CH 2 CF 3, C 3 -C 7 cycloalkyl, C 2 -C 10 alkenyl, SO 2 -R 8, or a 4 to 6 membered saturated ring containing an oxygen atom; R 5 is present where Y is C, and is selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, CO(R 7), CF 3 and halogen; R 5 is absent where X is N; R 6 is selected from the group consisting of H, C 1 -C 6 alkyl, COOCH 3, and CONHSO 2 CH 3; R 7 is selected from the group consisting of OH, O(C 1 -C 6 alkyl), NH 2, NHSO 2 N(C 1 -C 6 alkyl) 2, NHSO 2 NHCH 3, NHSO 2 (C 1 -C 6 alkyl), NHSO 2 (C 3 -C 7 cycloalkyl), and N(C 1 -C 6 -alkyl) 2; n is an integer from 2 to 6; R 8 and R 9 are each independently chosen from H, C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl or R 8 and R 9 taken together form a 4 to 6 membered aliphatic ring that optionally contains a heteroatom selected from the group N, S, O; R 10 is selected from the group consisting of H, C 1 -C 6 alkyl, OH, CN, F, CF 2 H, CF 3, CONR 8 R 9, COOR 8, CONR 8 SO 2 R 9, CON(R 8)SO 2 N(R 8 R 9), NR 8 R 9, NR 8 COOR 9, OCOR 8, NR 8 SO 2 R 9, SO 2 NR 8 R 9, SO 2 R 8 or a 4 to 6 membered saturated ring containing an oxygen atom.