A compound having the structure of Formula: or a stereoisomer, enantiomer, enantiomeric mixture or pharmaceutically acceptable salt thereof; wherein: Y is N or CR a; R a, R 1, R 3, R 5, R 6, R 7, R 8 and R 9 are independently H, halogen or -C 1 -C 4 alkyl; R 2 is -CN, -C 1 -C 6 alkyl, -hydroxyC 1 -C 4 alkylene, -C 1 -C 4 alkoxy, -C 2 -C 4 alkoxy substituted with 1-2 hydroxyl; -(CR 13 R 14) n C(=O)NR 11 R 12, -(CR 13 R 14) n C(=O)NR 11 R 15; -(CR 13 R 14) n C(=O)R 15; -(CR 2) n NR 11 C(=O)R 15, -(CR 2) n NR 11 (CR 2) 2 C(=O)R 15; -(CR 2) n NR-C(=O)OR 11,-(CR 2) n NR-C(=O)O-(CR 2)-R 15; -NR-C(=O)(CR 2) 2 C(=O)R 15, -NR-C(=O)R 11; -(CR 2) n NR 11 R 12, -(CR 2) n NR 11 (CR 2) n R 15; -(CR 2) n OR 15, -(CR 2) n R 15; or a 5- to 6- membered heteroaryl having 1 to 4 heteroatoms independently selected from O, S and N; R 4a, R 4b, R 4c and R 4d are independently H or -C 1 -C 4 alkyl; R 10 is H, halogen, -C 1 -C 4 alkyl, -C 1 -C 4 alkoxy, -C 1 -C 4 haloalkoxy or -NH(C 1 -C 4 alkyl); R 11 is H, -C 1 -C 4 alkyl, -hydroxyC 1 -C 4 alkylene, -cyanoC 1 -C 4 alkylene or -C 1 -C 4 alkyl substituted with -C 1 -C 4 alkoxy; R 12 is H or -C 1 -C 4 alkyl; R 13 is H, halogen, -CN, -OH, -C 1 -C 4 alkyl or -hydroxyC 1 -C 4 alkylene; R 14 is H, halogen or -C 1 -C 4 alkyl; R15 is -C 3 -C 6 cycloalkyl, or a 4- to 6-membered heterocycoalkyl having 1-2 heteroatoms independently selected from O, S, S(=O) 2, and N; wherein said -C 3 -C 6 cycloalkyl or 4- to 6-membered heterocycloalkyl of R 15 is unsubstituted or substituted with 1-2 substituents selected from -OH, -C 1 -C 4 alkyl, -hydroxyC 1 -C 4 alkylene, -C 1 -C 4 alkoxy, -SO 2 (C 1 -C 4 alkyl) and -N(C 1 -C 4 alkyl) 2; R 16, if present, is a substituent selected from halogen, -CN, -OH, -C 1 -C 4 alkyl and -hydroxyC 1 -C 4 alkylene; each R is independently H or -C 1 -C 4 alkyl; m is 0, 1 or 2; and each n is independently selected from 0, 1 and 2. Y is N or CR a; R a, R 1, R 3, R 5, R 6, R 7, R 8 and R 9 are independently H, halogen or -C 1 -C 4 alkyl; R 2 is -CN, -C 1 -C 6 alkyl, -hydroxyC 1 -C 4 alkylene, -C 1 -C 4 alkoxy, -C 2 -C 4 alkoxy substituted with 1-2 hydroxyl; -(CR 13 R 14) n C(=O)NR 11 R 12, -(CR 13 R 14) n C(=O)NR 11 R 15; -(CR 13 R 14) n C(=O)R 15; -(CR 2) n NR 11 C(=O)R 15, -(CR 2) n NR 11 (CR 2) 2 C(=O)R 15; -(CR 2) n NR-C(=O)OR 11,-(CR 2) n NR-C(=O)O-(CR 2)-R 15; -NR-C(=O)(CR 2) 2 C(=O)R 15, -NR-C(=O)R 11; -(CR 2) n NR 11 R 12, -(CR 2) n NR 11 (CR 2) n R 15; -(CR 2) n OR 15, -(CR 2) n R 15; or a 5- to 6- membered heteroaryl having 1 to 4 heteroatoms independently selected from O, S and N; R 4a, R 4b, R 4c and R 4d are independently H or -C 1 -C 4 alkyl; R 10 is H, halogen, -C 1 -C 4 alkyl, -C 1 -C 4 alkoxy, -C 1 -C 4 haloalkoxy or -NH(C 1 -C 4 alkyl); R 11 is H, -C 1 -C 4 alkyl, -hydroxyC 1 -C 4 alkylene, -cyanoC 1 -C 4 alkylene or -C 1 -C 4 alkyl substituted with -C 1 -C 4 alkoxy; R 12 is H or -C 1 -C 4 alkyl; R 13 is H, halogen, -CN, -OH, -C 1 -C 4 alkyl or -hydroxyC 1 -C 4 alkylene; R 14 is H, halogen or -C 1 -C 4 alkyl; R15 is -C 3 -C 6 cycloalkyl, or a 4- to 6-membered heterocycoalkyl having 1-2 heteroatoms independently selected from O, S, S(=O) 2, and N; wherein said -C 3 -C 6 cycloalkyl or 4- to 6-membered heterocycloalkyl of R 15 is unsubstituted or substituted with 1-2 substituents selected from -OH, -C 1 -C 4 alkyl, -hydroxyC 1 -C 4 alkylene, -C 1 -C 4 alkoxy, -SO 2 (C 1 -C 4 alkyl) and -N(C 1 -C 4 alkyl) 2; R 16, if present, is a substituent selected from halogen, -CN, -OH, -C 1 -C 4 alkyl and -hydroxyC 1 -C 4 alkylene; each R is independently H or -C 1 -C 4 alkyl; m is 0, 1 or 2; and each n is independently selected from 0, 1 and 2.