A compound of Formula I: wherein A is: wherein e is 1 or 2; R A is methyl; each R B is fluoro, -CH 2 OH, -CH(CH 3)OH, -C(CH 3) 2 OH, -CH 2 NH(C=O)CH 3, -CH 2 CH 2 OH,-CH 2 (C=O)OH, -(C=O)OCH 3 or -(C=O)H; L is -O- or absent; a is 2, 3, 4, 5, 6, 7, or 8; b is 0 or 1; c is 0; d is 1; each R 1 and R 2 are independently hydrogen or C 1 -C 6 alkyl; R 3 is phenyl or 4-fluorophenyl; R 4 is hydrogen, methyl or fluorine; R 5 is hydrogen, fluorine, phenyl, cyclohexyl, or methyl; each R 6 and R 7 is hydrogen; each R 8 and R 9 is hydrogen; and B is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of: C 1-7 acyl (e.g., carboxyaldehyde); C 1-20 alkyl (e.g., C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkylsulfinyl-C 1-6 alkyl, amino-C 1-6 alkyl, azido-C 1-6 alkyl, (carboxyaldehyde)-C 1-6 alkyl, halo-C 1-6 alkyl (e.g., perfluoroalkyl), hydroxy-C 1-6 alkyl, nitro-C 1-6 alkyl, or C 1-6 thioalkoxy-C 1-6 alkyl); C 1-20 alkoxy (e.g., C 1-6 alkoxy, such as perfluoroalkoxy); C 1-6 alkylsulfinyl; C 6-10 aryl; amino; C 1-6 alk-C 6-10 aryl; azido; C 3-8 cycloalkyl; C 1-6 alk-C 3-8 cycloalkyl; halo; C 1-12 heterocyclyl (e.g., C 1-12 heteroaryl); (C 1-12 heterocyclyl)oxy; hydroxy; nitro; C 1-20 thioalkoxy (e.g., C 1-6 thioalkoxy); - (CH 2) q CO 2 R A', where q is an integer from zero to four, and R A' is selected from the group consisting of (a) C 1-6 alkyl, (b) C 6-10 aryl, (c) hydrogen, and (d) C 1-6 alk-C 6-10 aryl; - (CH 2) q CONR B' R C', where q is an integer from zero to four and where R B' and R C' are independently selected from the group consisting of (a) hydrogen, (b) C 1-6 alkyl, (c) C 6-10 aryl, and (d) C 1-6 alk-C 6-10 aryl; -(CH 2) q SO 2 R D', where q is an integer from zero to four and where R D' is selected from the group consisting of (a) alkyl, (b) C 6-10 aryl, and (c) alk-C 6-10 aryl; - (CH 2) q SO 2 NR E' R F', where q is an integer from zero to four and where each of R E' and R F' is, independently, selected from the group consisting of (a) hydrogen, (b) C 1-6 alkyl, (c) C 6-10 aryl, and (d) C 1-6 alk-C 6-10 aryl; thiol; C 6-10 aryloxy; C 3-8 cycloalkoxy; C 6-10 aryl-C 1-6 alkoxy; C 1-6 alk-C 1-12 heterocyclyl (e.g., C 1-6 alk-C 1-12 heteroaryl); C 2-20 alkenyl; and C 2-20 alkynyl, wherein the alkylene group of a C 1 -alkaryl or a C 1 -alkheterocyclyl can be further substituted with an oxo group to afford the respective aryloyl and (heterocyclyl)oyl substituent group; or a pharmaceutically acceptable salt thereof. wherein e is 1 or 2; R A is methyl; each R B is fluoro, -CH 2 OH, -CH(CH 3)OH, -C(CH 3) 2 OH, -CH 2 NH(C=O)CH 3, -CH 2 CH 2 OH,-CH 2 (C=O)OH, -(C=O)OCH 3 or -(C=O)H; L is -O- or absent; a is 2, 3, 4, 5, 6, 7, or 8; b is 0 or 1; c is 0; d is 1; each R 1 and R 2 are independently hydrogen or C 1 -C 6 alkyl; R 3 is phenyl or 4-fluorophenyl; R 4 is hydrogen, methyl or fluorine; R 5 is hydrogen, fluorine, phenyl, cyclohexyl, or methyl; each R 6 and R 7 is hydrogen; each R 8 and R 9 is hydrogen; and B is C 6 -C 10 aryl optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of: C 1-7 acyl (e.g., carboxyaldehyde); C 1-20 alkyl (e.g., C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkylsulfinyl-C 1-6 alkyl, amino-C 1-6 alkyl, azido-C 1-6 alkyl, (carboxyaldehyde)-C 1-6 alkyl, halo-C 1-6 alkyl (e.g., perfluoroalkyl), hydroxy-C 1-6 alkyl, nitro-C 1-6 alkyl, or C 1-6 thioalkoxy-C 1-6 alkyl); C 1-20 alkoxy (e.g., C 1-6 alkoxy, such as perfluoroalkoxy); C 1-6 alkylsulfinyl; C 6-10 aryl; amino; C 1-6 alk-C 6-10 aryl; azido; C 3-8 cycloalkyl; C 1-6 alk-C 3-8 cycloalkyl; halo; C 1-12 heterocyclyl (e.g., C 1-12 heteroaryl); (C 1-12 heterocyclyl)oxy; hydroxy; nitro; C 1-20 thioalkoxy (e.g., C 1-6 thioalkoxy); - (CH 2) q CO 2 R A', where q is an integer from zero to four, and R A' is selected from the group consisting of (a) C 1-6 alkyl, (b) C 6-10 aryl, (c) hydrogen, and (d) C 1-6 alk-C 6-10 aryl; - (CH 2) q CONR B' R C', where q is an integer from zero to four and where R B' and R C' are independently selected from the group consisting of (a) hydrogen, (b) C 1-6 alkyl, (c) C 6-10 aryl, and (d) C 1-6 alk-C 6-10 aryl; -(CH 2) q SO 2 R D', where q is an integer from zero to four and where R D' is selected from the group consisting of (a) alkyl, (b) C 6-10 aryl, and (c) alk-C 6-10 aryl; - (CH 2) q SO 2 NR E' R F', where q is an integer from zero to four and where each of R E' and R F' is, independently, selected from the group consisting of (a) hydrogen, (b) C 1-6 alkyl, (c) C 6-10 aryl, and (d) C 1-6 alk-C 6-10 aryl; thiol; C 6-10 aryloxy; C 3-8 cycloalkoxy; C 6-10 aryl-C 1-6 alkoxy; C 1-6 alk-C 1-12 heterocyclyl (e.g., C 1-6 alk-C 1-12 heteroaryl); C 2-20 alkenyl; and C 2-20 alkynyl, wherein the alkylene group of a C 1 -alkaryl or a C 1 -alkheterocyclyl can be further substituted with an oxo group to afford the respective aryloyl and (heterocyclyl)oyl substituent group; or a pharmaceutically acceptable salt thereof.