A high-intensity focused ultrasound operation device, comprising: a handle part for manipulation by an operator, wherein the handle part comprises a fixed part and a cartridge-rotating part rotatably coupled with the fixed part; a plurality of cartridges configured to be selectively coupled to and detached from the cartridge-rotating part of the handle part, wherein each of the plurality of cartridges has a cylinder or bar shape arranged to be inserted into a vagina during operation; an ultrasound treatment transducer provided inside each of the plurality of cartridges and configured to generate high-intensity focused ultrasound (HIFU), where a cartridge selected from the plurality of cartridges is mounted at a front end of the cartridge-rotating part of the handle part, and the cartridge-rotating part is configured to rotate the selected cartridge; a driver which is arranged inside the cartridge-rotating part of the handle part and which comprises a stepper motor for driving the ultrasound treatment transducer of the selected cartridge such that the ultrasound treatment transducer of the selected cartridge moves from front to back in a longitudinal direction of the cartridge; and a controller for controlling the driver, wherein the ultrasound treatment transducer of each of the plurality of cartridges comprises at least one independent transducer arranged to form a single or multiple thermal lesion with the high-intensity focused ultrasound at a location spaced apart from a vaginal inner-wall surface by a predetermined distance, and wherein the cartridge-rotating part of the handle part comprises a guider for fastening with the cartridge. a handle part for manipulation by an operator, wherein the handle part comprises a fixed part and a cartridge-rotating part rotatably coupled with the fixed part; a plurality of cartridges configured to be selectively coupled to and detached from the cartridge-rotating part of the handle part, wherein each of the plurality of cartridges has a cylinder or bar shape arranged to be inserted into a vagina during operation; an ultrasound treatment transducer provided inside each of the plurality of cartridges and configured to generate high-intensity focused ultrasound (HIFU), where a cartridge selected from the plurality of cartridges is mounted at a front end of the cartridge-rotating part of the handle part, and the cartridge-rotating part is configured to rotate the selected cartridge; a driver which is arranged inside the cartridge-rotating part of the handle part and which comprises a stepper motor for driving the ultrasound treatment transducer of the selected cartridge such that the ultrasound treatment transducer of the selected cartridge moves from front to back in a longitudinal direction of the cartridge; and a controller for controlling the driver, wherein the ultrasound treatment transducer of each of the plurality of cartridges comprises at least one independent transducer arranged to form a single or multiple thermal lesion with the high-intensity focused ultrasound at a location spaced apart from a vaginal inner-wall surface by a predetermined distance, and wherein the cartridge-rotating part of the handle part comprises a guider for fastening with the cartridge.