mhurhangee/ep-ind-claims huggingface dataset:
An isolated BKV serotype I (BKV-I) capsid polypeptide or a nucleic acid encoding the BKV-I capsid polypeptide; and an isolated BKV serotype IV (BKV-IV) capsid polypeptide or a nucleic acid encoding the BKV-IV capsid polypeptide for use in a method of eliciting an immune response against a BK polyomavirus in a subject, the method comprising administering to a subject in need of enhanced immunity to BKV: a therapeutically effective amount of at least one of the isolated BKV serotype I (BKV-I) capsid polypeptide or a nucleic acid encoding the at least one BKV-I capsid polypeptide; and a therapeutically effective amount of at least one of the isolated BKV serotype IV (BKV-IV) capsid polypeptide or a nucleic acid encoding the at least one BKV-IV capsid polypeptide, thereby eliciting an immune response against the BKV, wherein the at least one BKV-I capsid polypeptide and the at least one BKV-IV capsid polypeptide are administered concurrently or sequentially. a therapeutically effective amount of at least one of the isolated BKV serotype I (BKV-I) capsid polypeptide or a nucleic acid encoding the at least one BKV-I capsid polypeptide; and a therapeutically effective amount of at least one of the isolated BKV serotype IV (BKV-IV) capsid polypeptide or a nucleic acid encoding the at least one BKV-IV capsid polypeptide, thereby eliciting an immune response against the BKV, wherein the at least one BKV-I capsid polypeptide and the at least one BKV-IV capsid polypeptide are administered concurrently or sequentially.
A sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, wherein the cyclosporine is in the form of particles and wherein the cyclosporine particles are dispersed within the hydrogel wherein the hydrogel comprises a polymer network comprising one or more crosslinked multi-arm polymer units, the multi-arm polymer units comprising one or more 2- to 10-arm polyethylene glycol units, and the cyclosporine particles have a d50 value of less than about 50 μm as measured by laser diffraction in accordance with USP <429>. the hydrogel comprises a polymer network comprising one or more crosslinked multi-arm polymer units, the multi-arm polymer units comprising one or more 2- to 10-arm polyethylene glycol units, and the cyclosporine particles have a d50 value of less than about 50 μm as measured by laser diffraction in accordance with USP <429>.
Apparatus for QRS waveform quantifying, comprising: an input unit (310, 410. 510, 610, 710), for receiving a plurality of high frequency range QRS complexes from at least one ECG lead; a primary analyzer (320, 420, 630, 720), associated with said input unit, for calculating a plurality of primary indices, each of said primary indices calculated from at least one of said plurality of high frequency range QRS complexes, wherein a first primary index is calculated from a first HF range QRS complex in a first time period and a second primary index is calculated from a second HF range QRS complex in a second time period, said first and second time periods being different and not coinciding; and a secondary analyzer, connected after said primary analyzer, for deriving a secondary index from said plurality of primary indices, thereby to provide a quantification of QRS complexes wherein said secondary index is a function of said first primary index and said second primary index, characterized by said secondary index being a running average of said plurality of primary indices. an input unit (310, 410. 510, 610, 710), for receiving a plurality of high frequency range QRS complexes from at least one ECG lead; a primary analyzer (320, 420, 630, 720), associated with said input unit, for calculating a plurality of primary indices, each of said primary indices calculated from at least one of said plurality of high frequency range QRS complexes, wherein a first primary index is calculated from a first HF range QRS complex in a first time period and a second primary index is calculated from a second HF range QRS complex in a second time period, said first and second time periods being different and not coinciding; and a secondary analyzer, connected after said primary analyzer, for deriving a secondary index from said plurality of primary indices, thereby to provide a quantification of QRS complexes wherein said secondary index is a function of said first primary index and said second primary index, characterized by said secondary index being a running average of said plurality of primary indices.
A photonic crystal fiber, PCF, assembly comprising a PCF and at least one ferrule structure, said PCF has a center axis and comprises a core region and a cladding region and a first fiber end section with a first fiber end, said ferrule structure has a center axis and is mounted to said first fiber end section, the PCF center axis at the first fiber end section and the ferrule structure center axis being parallel or coincident, said ferrule structure comprises an inner ferrule arrangement and an outer ferrule arrangement surrounding the first fiber end section, said inner ferrule arrangement comprises an inner ferrule front section proximally to said first fiber end and an inner ferrule rear section distally to said first fiber end, said inner ferrule front section and said inner ferrule rear section are not directly fixed to each other and the outer ferrule arrangement is configured to hold the inner ferrule front section and the inner ferrule rear section in position relative to each other, each of said inner ferrule sections (22, 23) have an inner diameter and in at least a length thereof fully surrounds the PCF, said inner ferrule rear section is anchored in an anchor length section to said first fiber end section and said inner ferrule front section supports said first fiber end section proximally to said first fiber end, characterized in that said first fiber end section has at least one mode stripper length section (27, 37) configured to remove cladding modes, and wherein said at least one mode stripper length section (27, 37) comprises a mode stripping high index material and/or a scattering layer applied in contact with the first fiber end section at said at least one mode stripper length section (27, 37) and/or said first fiber end section in said at least one mode stripper length section (27, 37) has a roughness Ra value of at least about 0.1 μm. characterized in that said first fiber end section has at least one mode stripper length section (27, 37) configured to remove cladding modes, and wherein said at least one mode stripper length section (27, 37) comprises a mode stripping high index material and/or a scattering layer applied in contact with the first fiber end section at said at least one mode stripper length section (27, 37) and/or said first fiber end section in said at least one mode stripper length section (27, 37) has a roughness Ra value of at least about 0.1 μm.
A drug delivery molecule for use in treating triple-negative breast cancer in a patient, the drug delivery molecule comprising: (a) a polypeptide adapted to target and penetrate a type of cell, the polypeptide comprising a Her segment obtained from the receptor binding domain of heregulin-a and that binds HER3; and (b) (i) a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemotherapeutic agent non-covalently linked to the nucleic acid molecule; or (ii) a corrole molecule bound to the polypeptide molecule. (a) a polypeptide adapted to target and penetrate a type of cell, the polypeptide comprising a Her segment obtained from the receptor binding domain of heregulin-a and that binds HER3; and (b) (i) a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemotherapeutic agent non-covalently linked to the nucleic acid molecule; or (ii) a corrole molecule bound to the polypeptide molecule. (i) a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemotherapeutic agent non-covalently linked to the nucleic acid molecule; or (ii) a corrole molecule bound to the polypeptide molecule.
A surgical instrument, comprising: a housing; an outer shaft extending from the housing along a longitudinal axis; an inner shaft extending within the outer shaft along the longitudinal axis; a rotator knob positioned about the outer shaft; a tube stop coupling the rotator knob to the outer shaft for collective rotation about the longitudinal axis and fixed within the housing against movement along the longitudinal axis; and a pair of tracks, characterized in that the pair of tracks extends longitudinally in the outer shaft, the tube stop comprises a pair of bearing surfaces extending into the pair of tracks, respectively, and the rotator knob includes a pair of rails, which extend into the pair of tracks of the outer shaft, respectively. a housing; an outer shaft extending from the housing along a longitudinal axis; an inner shaft extending within the outer shaft along the longitudinal axis; a rotator knob positioned about the outer shaft; a tube stop coupling the rotator knob to the outer shaft for collective rotation about the longitudinal axis and fixed within the housing against movement along the longitudinal axis; and a pair of tracks, characterized in that the pair of tracks extends longitudinally in the outer shaft, the tube stop comprises a pair of bearing surfaces extending into the pair of tracks, respectively, and the rotator knob includes a pair of rails, which extend into the pair of tracks of the outer shaft, respectively.
High frequency power transistor, comprising: - a transistor (2, 18), - at least one capacitor (3, 18), - a housing at least partially surrounding the transistor (2, 18) and the capacitor (3, 18), wherein a first terminal for a high frequency input and a gate direct voltage supply is connected to a gate contact of the transistor (2, 18), wherein a second terminal is connected to a drain contact of the transistor (2, 18) for a high frequency output and drain direct voltage supply, and wherein a third terminal and a fourth terminal are connected to a source contact of the transistor (2, 18), and wherein the first, second, third and fourth terminals (4, 6, 9, 10) all lead out of the housing, and wherein the third terminal is connected to the source contact via the capacitor (3, 18) and the fourth terminal is connected to the source contact via at least one inductive element (36, 11), such that the third terminal provides a high frequency ground and the fourth terminal provides a potential-free low frequency ground and source direct voltage supply, wherein the inductive element (36, 11) comprises one bonding wire or more bonding wires connected in parallel, wherein the one or more bonding wires connected in parallel form a low pass network (3.2), and wherein a length and number of the bonding wires is designed to set an LF bandwidth of the low-pass network (3.2). - a transistor (2, 18), - at least one capacitor (3, 18), - a housing at least partially surrounding the transistor (2, 18) and the capacitor (3, 18), wherein a first terminal for a high frequency input and a gate direct voltage supply is connected to a gate contact of the transistor (2, 18), wherein a second terminal is connected to a drain contact of the transistor (2, 18) for a high frequency output and drain direct voltage supply, and wherein a third terminal and a fourth terminal are connected to a source contact of the transistor (2, 18), and wherein the first, second, third and fourth terminals (4, 6, 9, 10) all lead out of the housing, and wherein the third terminal is connected to the source contact via the capacitor (3, 18) and the fourth terminal is connected to the source contact via at least one inductive element (36, 11), such that the third terminal provides a high frequency ground and the fourth terminal provides a potential-free low frequency ground and source direct voltage supply, wherein the inductive element (36, 11) comprises one bonding wire or more bonding wires connected in parallel, wherein the one or more bonding wires connected in parallel form a low pass network (3.2), and wherein a length and number of the bonding wires is designed to set an LF bandwidth of the low-pass network (3.2).
A passive electronic fuse for protecting a DC application in the event of a fault, the electronic fuse comprises: - a first leg comprising a first winding of a mutual inductor and a switch device connected in series, - a second leg comprising a second winding of the mutual inductor, wherein the first leg and the second leg are connected in parallel and a self-inductance of the second winding is lower than a self-inductance of the first winding, characterized in that the second leg further comprises a capacitor connected in series with the second winding of the mutual inductor, wherein the switch device is a thyristor or a switch device with switching properties of a thyristor. - a first leg comprising a first winding of a mutual inductor and a switch device connected in series, - a second leg comprising a second winding of the mutual inductor,
A supervision method (200, 300, 600, 700, 1000, 1100) for a flight state of an unmanned aerial vehicle, wherein the supervision method (200, 300, 600, 700, 1000, 1100) is applied in an unmanned aerial vehicle and comprises the steps of: establishing a communication connection with a control terminal of the unmanned aerial vehicle; receiving and storing an off-line flight certificate sent by the control terminal, wherein the off-line flight certificate was generated according to identity information about a user of the unmanned aerial vehicle and off-line flight parameters reported by the user of the unmanned aerial vehicle, and wherein the off-line flight certificate comprises the off-line flight parameters; and monitoring and restricting, when the unmanned aerial vehicle is in an off-line flight mode, flight behaviour of the unmanned aerial vehicle in the off-line flight mode according to the off-line flight parameters in the off-line flight certificate, wherein restricting, when the unmanned aerial vehicle is in the off-line flight mode, the flight behaviour of the unmanned aerial vehicle is based on monitoring, when the unmanned aerial vehicle is in the off-line flight mode, whether flight information about the unmanned aerial vehicle conforms to the reported flight information. establishing a communication connection with a control terminal of the unmanned aerial vehicle; receiving and storing an off-line flight certificate sent by the control terminal, wherein the off-line flight certificate was generated according to identity information about a user of the unmanned aerial vehicle and off-line flight parameters reported by the user of the unmanned aerial vehicle, and wherein the off-line flight certificate comprises the off-line flight parameters; and monitoring and restricting, when the unmanned aerial vehicle is in an off-line flight mode, flight behaviour of the unmanned aerial vehicle in the off-line flight mode according to the off-line flight parameters in the off-line flight certificate, wherein restricting, when the unmanned aerial vehicle is in the off-line flight mode, the flight behaviour of the unmanned aerial vehicle is based on monitoring, when the unmanned aerial vehicle is in the off-line flight mode, whether flight information about the unmanned aerial vehicle conforms to the reported flight information.
The compound 1-(4,6-dipentyl-5,6-dihydro-2H-1,2,3-oxadiazin-2-yl)-3-hydroxypropan-1-one or a pharmaceutical composition comprising said compound and a pharmaceutically acceptable excipient wherein the compound or the pharmaceutical composition are for use in preventing and/or treating an infection caused by a bacterium, fungus or virus or for use in preventing and/or treating cancer, wherein the cancer is selected from the group consisting of breast cancer; biliary tract cancer; bladder cancer; brain cancer; glioblastomas, glioblastoma multiforme, medulloblastomas; head and neck cancer; choriocarcinoma; colon cancer, colorectal cancer; endometrial cancer; esophageal cancer; gastric cancer; hematological neoplasms, acute lymphocytic and myelogenous leukemia; T-cell acute lymphoblastic leukemia/lymphoma; hairy cell leukemia; chronic myelogenous leukemia, multiple myeloma; AIDS-associated leukemias, adult T-cell leukemia/lymphoma; intraepithelial neoplasms, Bowen's disease, Paget's disease; lung cancer, pleural mesothelioma; lymphomas, Hodgkin's disease, lymphocytic lymphomas; neuroblastomas; oral cancer, squamous cell carcinoma; parotid gland cancer; ovarian cancer, ovarian cancer arising from epithelial cells, stromal cells, germ cells and mesenchymal cells; prostate cancer; kidney cancer, suprarenal cancer; rectal cancer; sarcomas, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, fibrosarcoma, osteosarcoma; skin cancer, melanoma, Merkel cell carcinoma, Kaposi's sarcoma, basal cell carcinoma, squamous cell cancer; endometrial cancer; testicular cancer, germinal tumors, seminoma, non-seminoma, teratomas, choriocarcinomas, stromal tumors, germ cell tumors; thyroid cancer, thyroid adenocarcinoma, medullar carcinoma;, renal cancer, adenocarcinoma, and Wilms tumor.
A canvas hanger profile (6a, 6b, 24, 32, 34) for making a stretched ceiling in a room to be conditioned, the hanger profile comprising at least two wings (61, 63) connected together by a connecting lining, one of the wings being arranged to allow the fastening of the hanger profile on a wall of the room to be conditioned, a second wing, which constitutes a canvas hanger wing, being provided with a blocking end of a canvas hook, the connecting lining and the canvas hanger wing being arranged to define together an unclosed air passage slot through the profile and delimited by the blocking end of the canvas hanger wing hook, the profile having at least one through opening arranged to allow air to pass through said profile from or towards the slot, characterized in that the through opening is provided on the connecting lining.
A method for producing a computer representation of a three-dimensional surface (220,227) of an appliance for a living body, the method comprising identifying a plurality of spaced apart planes (222,224,226) intersecting the three-dimensional surface, the method characterized by: for each plane in said plurality of spaced apart planes: identifying a plurality of basis points (230,346,380) on said plane, said basis points lying generally along a curve (232,334,352,358,382) on said plane; determining surface coordinate locations of a plurality of points on said plane that lie on said three-dimensional surface, each surface coordinate location being defined as an offset (238,384) from one of said plurality of basis points; and storing said surface coordinate locations in a computer memory. for each plane in said plurality of spaced apart planes: identifying a plurality of basis points (230,346,380) on said plane, said basis points lying generally along a curve (232,334,352,358,382) on said plane; determining surface coordinate locations of a plurality of points on said plane that lie on said three-dimensional surface, each surface coordinate location being defined as an offset (238,384) from one of said plurality of basis points; and storing said surface coordinate locations in a computer memory. identifying a plurality of basis points (230,346,380) on said plane, said basis points lying generally along a curve (232,334,352,358,382) on said plane; determining surface coordinate locations of a plurality of points on said plane that lie on said three-dimensional surface, each surface coordinate location being defined as an offset (238,384) from one of said plurality of basis points; and storing said surface coordinate locations in a computer memory.
An in situ pipe spray liner device comprising: at least one remotely adjustable rotatable spray nozzle; a rotational shaft to which the at least one spray nozzle is affixed; a remotely adjustable scissor lift table and one or more proximity sensors or gyroscopes arranged and adapted to center one or more of the spray nozzles in a vertical direction; a remotely operable rotational table for centering one or more of the spray nozzles in a horizontal direction; and a pendulum roller bracket arranged and adapted to cause the rotational shaft and the at least one spray nozzle to move from side to side in a pendulum pattern. at least one remotely adjustable rotatable spray nozzle; a rotational shaft to which the at least one spray nozzle is affixed; a remotely adjustable scissor lift table and one or more proximity sensors or gyroscopes arranged and adapted to center one or more of the spray nozzles in a vertical direction; a remotely operable rotational table for centering one or more of the spray nozzles in a horizontal direction; and a pendulum roller bracket arranged and adapted to cause the rotational shaft and the at least one spray nozzle to move from side to side in a pendulum pattern.
A method of establishing secure communication between a server and a device in a distributed control system, wherein a first public-private key pair comprising a server public key and a server private key is associated with the server, and wherein a second public-private key pair comprising a device public key and a device private key is associated with the device, the method comprising: with the server, generating a server nonce; transmitting the server public key, a server key signature, and the server nonce from the server to the device; with the device, verifying the server public key, signing the server nonce with the device private key, resulting in a server nonce signature, and generating a device nonce; transmitting the server nonce, the server nonce signature, the device public key, a device key signature, and the device nonce from the device to the server; with the server, verifying the server nonce, verifying the device public key, generating a session key, encrypting the session key with the device public key, resulting in an encrypted session key, and signing a combination of the device nonce and the session key with the server private key, resulting in a combined signature; transmitting the device nonce, the combined signature, and the encrypted session key from the server to the device; and with the device, verifying the device nonce, decrypting the encrypted session key with the device private key, resulting in a decrypted session key, and verifying the decrypted session key. with the server, generating a server nonce; transmitting the server public key, a server key signature, and the server nonce from the server to the device; with the device, verifying the server public key, signing the server nonce with the device private key, resulting in a server nonce signature, and generating a device nonce; transmitting the server nonce, the server nonce signature, the device public key, a device key signature, and the device nonce from the device to the server; with the server, verifying the server nonce, verifying the device public key, generating a session key, encrypting the session key with the device public key, resulting in an encrypted session key, and signing a combination of the device nonce and the session key with the server private key, resulting in a combined signature; transmitting the device nonce, the combined signature, and the encrypted session key from the server to the device; and with the device, verifying the device nonce, decrypting the encrypted session key with the device private key, resulting in a decrypted session key, and verifying the decrypted session key.