mhurhangee/ep-ind-claims huggingface dataset:
Automatic injection training device comprising: - an elongated housing having a distal end and an opposite proximal end and extending along a longitudinally axis; - a tubular demo container axially and rotationally fixed relative to the elongated housing and having a tubular wall extending along the longitudinally axis; - a reloadable plunger assembly comprising a plunger rod which is movable in the demo container between a first and a second position and a first energy accumulating element configured to move the plunger rod from the first to the second position; - an actuation assembly configured to hold the plunger rod in the first position and to release the plunger rod from the first position; characterized in that the device further comprises a first signal generating element causing a first audible feedback signal and releasably connected to the plunger rod and a second signal generating element causing a second audible feedback signal and fixedly connected to the plunger rod, and wherein each signal generating element (96; 126) is configured to interact independently from each other for generating audible feedback signals. - an elongated housing having a distal end and an opposite proximal end and extending along a longitudinally axis; - a tubular demo container axially and rotationally fixed relative to the elongated housing and having a tubular wall extending along the longitudinally axis; - a reloadable plunger assembly comprising a plunger rod which is movable in the demo container between a first and a second position and a first energy accumulating element configured to move the plunger rod from the first to the second position; - an actuation assembly configured to hold the plunger rod in the first position and to release the plunger rod from the first position; characterized in that the device further comprises a first signal generating element causing a first audible feedback signal and releasably connected to the plunger rod and a second signal generating element causing a second audible feedback signal and fixedly connected to the plunger rod, and wherein each signal generating element (96; 126) is configured to interact independently from each other for generating audible feedback signals.
A distribution machine, in particular a pneumatic fertiliser spreader, for spreading granular agricultural spreading material, with a frame structure carrying the components of the distribution machine, a storage hopper for carrying along and/or supplying the spreading material, as well as with a distribution boom extending transverse to a driving direction, which distribution boom has a carrier, a central part, and side booms swivelably arranged on the central part, wherein distribution tubes with distribution elements are arranged on the distribution boom, and wherein the distribution tubes are suppliable with an air volume flow for conveying the spreading material to the distribution elements, wherein spreading material is meterable into the distribution tubes by means of at least one metering device, which forms a constructional unit with the distribution boom and is operatively connected to the storage hopper, characterised in that the supply of the distribution tubes with an air volume flow is carried out by means of a flow generation device that is operable at variable rotational speeds, wherein the flow generation device is assigned an air flow divider by means of which the air volume flow generated by the flow generation device is divided into a plurality of air volume flows. with a frame structure carrying the components of the distribution machine, a storage hopper for carrying along and/or supplying the spreading material, as well as with a distribution boom extending transverse to a driving direction, which distribution boom has a carrier, a central part, and side booms swivelably arranged on the central part, wherein distribution tubes with distribution elements are arranged on the distribution boom, and wherein the distribution tubes are suppliable with an air volume flow for conveying the spreading material to the distribution elements, wherein spreading material is meterable into the distribution tubes by means of at least one metering device, which forms a constructional unit with the distribution boom and is operatively connected to the storage hopper, characterised in that the supply of the distribution tubes with an air volume flow is carried out by means of a flow generation device that is operable at variable rotational speeds, wherein the flow generation device is assigned an air flow divider by means of which the air volume flow generated by the flow generation device is divided into a plurality of air volume flows.
A method of selecting a human subject, diagnosed with cancer whose cancer cells have non-overexpressed, non-amplified ErbB2 receptor, for treatment with a targeted therapeutic agent that affects an ErbB signaling pathway the method comprising: - preparing a sample of viable primary cancer cells obtained from the subject and culturing the sample in base media; - contacting a first portion of the sample of viable primary cancer cells obtained from the subject with a perturbing agent, and a second portion of the sample with a perturbing agent and a confirming agent, wherein the perturbing agent selectively affects the ErbB signaling pathway and the confirming agent selectively inhibits the effect of the perturbing agent on the same ErbB signaling pathway; - continuously measuring cell adhesion or attachment of the viable primary cancer cells in each portion of the sample; - determining by mathematical analysis of the continuous measurements of cell adhesion or attachment the reduction in cell adhesion or attachment between the first portion of the sample and the second portion of the sample; and - selecting the subject for treatment with the targeted therapeutic agent when the reduction is greater than 50%. - preparing a sample of viable primary cancer cells obtained from the subject and culturing the sample in base media; - contacting a first portion of the sample of viable primary cancer cells obtained from the subject with a perturbing agent, and a second portion of the sample with a perturbing agent and a confirming agent, wherein the perturbing agent selectively affects the ErbB signaling pathway and the confirming agent selectively inhibits the effect of the perturbing agent on the same ErbB signaling pathway; - continuously measuring cell adhesion or attachment of the viable primary cancer cells in each portion of the sample; - determining by mathematical analysis of the continuous measurements of cell adhesion or attachment the reduction in cell adhesion or attachment between the first portion of the sample and the second portion of the sample; and - selecting the subject for treatment with the targeted therapeutic agent when the reduction is greater than 50%.
A grate comprising a first frame and an assembly of first and second bars (14, 15) coupled to the first frame in a freely sliding fashion along a certain direction and positioned alternately to each other; each first bar being connected to at least one consecutive second bar by a plurality of first connecting levers in such a way as to form a grid which can be freely switched between a first open position, in which the first and second bars (14, 15) are spaced apart, and the grid presents its maximum extension in the direction, and a second position of minimum longitudinal extension, in which the first and second bars (14, 15) are arranged close together in the direction; the first connecting levers being coupled to the respective first and second bars (14, 15) exclusively by means of turning pairs; the turning pairs of each first and second bar (14, 15) being respectively aligned with each other along a respective single axis, characterised in that the grate comprises first elongated box bodies which externally delimit the first bars, to completely contain the turning pairs; second elongated box bodies which externally delimit the second bars, being designed to contain the turning pairs; the first and second box bodies (32, 33) being designed to increase the resistance to cutting of the respective first and second bars (14, 15) and to protect the turning pairs, inside the respective first box body the first bars comprising at least one first rod; inside the respective second box body each of the second bars comprising at least one second rod; each turning pair associated with a first bar and a second bar comprising a pin equipped with a transverse housing respectively accommodating each first rod of the corresponding first bar in a rigidly axial fashion or each second rod of the corresponding second bar in a rigidly axial fashion, and in that each second box body presents a closed cross-section so as to bilaterally accommodate the coupling means of each corresponding second rod; and presents at least one longitudinal slit engaged by at least one of the first levers.
A bispecific antibody capable of neutralizing HIV, wherein the antibody comprises a light chain and heavy chain of a first antibody 10E8, that binds to the HIV envelope protein gp41, and a light chain and heavy chain of a second antibody ibalizumab, that binds to the cell membrane receptor protein CD4, wherein the light chain of the first antibody 10E8 comprises the amino acid sequence of SEQ ID NO: 33, and the heavy chain of the first antibody 10E8 comprises the amino acid sequence of SEQ ID NO: 34; and the light chain of the second antibody ibalizumab comprises the amino acid sequence of SEQ ID NO: 1, and the heavy chain of the second antibody ibalizumab comprises the amino acid sequence of SEQ ID NO: 2. the light chain of the first antibody 10E8 comprises the amino acid sequence of SEQ ID NO: 33, and the heavy chain of the first antibody 10E8 comprises the amino acid sequence of SEQ ID NO: 34; and the light chain of the second antibody ibalizumab comprises the amino acid sequence of SEQ ID NO: 1, and the heavy chain of the second antibody ibalizumab comprises the amino acid sequence of SEQ ID NO: 2.
Shearable screw for a wire connection assembly, such as a spliced connector or a lug, comprising, along an axial direction of the screw, a driving section, a threaded section with an outer screw thread for being engaged with a corresponding thread of a connector body of the wire connection assembly, and with a contact section for establishing electrical contact with a stranded wire, the screw having a predefined shear torque, wherein at least in the threaded section, the predefined shear torque of the screw varies in the axial direction of the screw, and wherein the screw further comprises at least one breaking line which extends in the material of the screw at least in the threaded section, the course of the at least one breaking line differing from the course of at least one outer screw thread, characterized in that the at least one breaking line is formed as helical groove in the outer surface of the screw spiraling around a central axis of the screw.
A crystalline free base of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8 H -pyrido[2,3- d]pyrimidin-7-one, having a specific surface area of ≤ 2 m 2 /g, and wherein the crystalline free base is a polymorph Form A of the free base having a powder X-ray diffraction pattern comprising a peak at diffraction angle (2θ) of 10.1 ± 0.2.
An air conditioning system comprising: a condenser having a header plate and conduits supported by the header plate, the conduits being configured to contain a flow of refrigerant for heat transfer within the condenser, and wherein the conduits extend through the header plate; a temperature sensor; a fan configured to direct air flow across the conduits within the condenser, along an interior side of the header plate, the temperature sensor mounted to an exterior side of the header plate and outside of an interior volume of the condenser so as to shield the temperature sensor from the air flow; and a controller in communication with the temperature sensor and the fan, the controller being configured to: receive from the temperature sensor an indicator of a temperature of the exterior side of the header plate; and control the fan to direct air flow across the conduits within the condenser, based on the indicator of the temperature. a condenser having a header plate and conduits supported by the header plate, the conduits being configured to contain a flow of refrigerant for heat transfer within the condenser, and wherein the conduits extend through the header plate; a temperature sensor; a fan configured to direct air flow across the conduits within the condenser, along an interior side of the header plate, the temperature sensor mounted to an exterior side of the header plate and outside of an interior volume of the condenser so as to shield the temperature sensor from the air flow; and a controller in communication with the temperature sensor and the fan, the controller being configured to: receive from the temperature sensor an indicator of a temperature of the exterior side of the header plate; and control the fan to direct air flow across the conduits within the condenser, based on the indicator of the temperature. receive from the temperature sensor an indicator of a temperature of the exterior side of the header plate; and control the fan to direct air flow across the conduits within the condenser, based on the indicator of the temperature.
A bending machine for material in wire, bar or strip form, in particular for producing bows for reinforced concrete construction, comprising a carrier frame (11, 12), at least one bending head, at least one feed device with which the material to be bent can be fed to the at least one bending head, and a cutting device arranged between the at least one bending head and the at least one feed device, formed from at least one blade and at least one counterpart blade, wherein the at least one blade and the at least one counterpart blade are moveable relative to each other, wherein the at least one counterpart blade of the cutting device is arranged at a first spacing relative to the bending head and is immovably connected to the carrier frame (11, 12), and the at least one blade of the cutting device is arranged at a device moveable relative to the carrier frame (11, 12), wherein the moveable device is at a second spacing relative to the bending head, that is greater than the first spacing of the at least one counterpart blade relative to the bending head, wherein the moveable device at which the at least one blade of the cutting device is arranged is the at least one feed device, wherein the at least one feed device has a first end towards the at least one bending head and a second opposite end, wherein the at least one blade of the cutting device is arranged at the first end and the at least one feed device is mounted at the second end to the carrier frame (11, 12) pivotably about a pivot point so that a relative movement between the at least one blade and the at least one counterpart blade of the cutting device can be caused by a pivotal movement of the at least one feed device about the pivot point to carry out a cut, characterised in that there is provided a lever arm which is connected at an end to the first end of the at least one feed device and is mounted at an opposite end pivotably about a pivot point to the carrier frame (11, 12) of the bending machine, wherein the lever arm and the at least one feed device include an angle of substantially 90°.
A process for producing a microporous graphite foam comprising a matrix of graphite fibers having a diameter in the range from 50 to 250 nanometers and a length in the range from 25 micrometres to 250 micrometres, said process comprising the steps of: providing a plurality of graphite fibers, wherein the graphite fibers are randomly curled; mixing the graphite fibers with a graphite-forming precursor; compressing the mixture; forming a precursor matrix comprising the graphite fiber and the graphite-forming precursor; first heating the matrix to a temperature at which the graphite-forming precursor is carbonized, forming a carbonized matrix; and second heating the carbonized matrix to a temperature at which the carbonized graphite-forming precursor is graphitized, forming the microporous graphite foam. providing a plurality of graphite fibers, wherein the graphite fibers are randomly curled; mixing the graphite fibers with a graphite-forming precursor; compressing the mixture; forming a precursor matrix comprising the graphite fiber and the graphite-forming precursor; first heating the matrix to a temperature at which the graphite-forming precursor is carbonized, forming a carbonized matrix; and second heating the carbonized matrix to a temperature at which the carbonized graphite-forming precursor is graphitized, forming the microporous graphite foam.
Portable electric machine, in particular hand-operated power tool or suction apparatus, comprising a circuit board module having a printed circuit board, on which conductors and electric components electrically connected to one another via the conductors are arranged on at least one flat side, wherein a conducting body assembly with at least one conducting body (238 - 242) separate from the printed circuit board is arranged on the flat side having the electric components or on an opposite flat side, and wherein at least one circuit board contact projection (247, 248) of the at least one conducting body (238 - 242), which projects in front of a conducting body connecting section extending along the flat side, penetrates the printed circuit board at a contact opening (245, 246) or penetrates into the printed circuit board, characterised in that an in particular plate-shaped intermediate body is arranged between the at least one conducting body (238 - 242) and the printed circuit board and/or an in particular plate-shaped or trough-like base body is arranged on a side of the at least one conducting body (238 - 242) which is remote from the printed circuit board, and in that the base body and/or the intermediate body has/have a conducting body receptacle (265, 271) for the accommodation of the at least one conducting body (238 - 242), wherein the flat sides of the at least one conducting body (238, 239, 241) are substantially in surface contact with internal walls of the conducting body receptacle.
A sintered electroconductive oxide characterized in that the oxide has a first crystal phase having a composition represented by RE1 4 Al 2 O 9 and a second crystal phase having a perovskite structure represented by (RE2 1-a SL a)MO 3, and that the factor a of the second crystal phase satisfies the following condition: 0.18<a<0.50, wherein RE1 represents a first element group consisting of at least one of Yb and Lu and at least one species selected from among group 3A elements (group 3 elements) excluding Yb, Lu, and La; RE2 represents a second element group which contains at least one species selected from among group 3A elements excluding La and which contains at least one species selected from the first element group RE1; M1 represents an element group consisting of at least one species selected from group 4A, 5A, 6A, 7A, and 8 elements (group 4 to group 10 elements); and M represents an element group consisting of the element group M1 and Al; and SL represents an element group consisting of Sr, Ca, and Mg, with at least Sr being included at a predominant proportion by mole.
A display package comprising: a) a primary inner pack, which is a double-barrelled syringe (2,3) that contains: a. a bulk composition b. two distinct physical parts and c. temporary sealing means, b) a plunger, and c) optionally one or more mixing elements, wherein • the two distinct physical parts contact the bulk composition or its constituents, • the first physical part located at one end of the primary pack is a removable cap which closes an orifice or orifices from where bulk composition is dispensed, • the second physical part at intermediate position within the primary pack is a group of two movable pistons (6,8) which contact and confine the bulk composition between itself and the end of the pack where the orifice or orifices are located, and, • temporary sealing means, which forms a barrier between volatile constituents emitted by the bulk composition and the outer secondary pack, and which means is located between the second physical part (6,8) and the distal end of the syringe, characterized in that the display package is for 2K cyanoacrylate compositions and comprises a secondary outer pack, wherein the bulk composition comprises i.Part A: a cyanoacrylate based adhesive composition, and ii.Part B: a composition comprising a mixture of plasticizer and catalyst or for a mixture of non-CA monomer and catalyst, and wherein the temporary sealing means are either: - partially confined within the primary inner pack and separated from the second physical part (6,8) by a gap and is a bung or cap, or, - confined within the primary inner pack but in initial intimate contact with the second physical part (6,8), it is not in intimate contact with the bulk composition, and is a grease, wax, or cured sealant. a) a primary inner pack, which is a double-barrelled syringe (2,3) that contains: a. a bulk composition b. two distinct physical parts and c. temporary sealing means, a. a bulk composition b. two distinct physical parts and c. temporary sealing means, b) a plunger, and c) optionally one or more mixing elements, • the two distinct physical parts contact the bulk composition or its constituents, • the first physical part located at one end of the primary pack is a removable cap which closes an orifice or orifices from where bulk composition is dispensed, • the second physical part at intermediate position within the primary pack is a group of two movable pistons (6,8) which contact and confine the bulk composition between itself and the end of the pack where the orifice or orifices are located, and, • temporary sealing means, which forms a barrier between volatile constituents emitted by the bulk composition and the outer secondary pack, and which means is located between the second physical part (6,8) and the distal end of the syringe, - partially confined within the primary inner pack and separated from the second physical part (6,8) by a gap and is a bung or cap, or, - confined within the primary inner pack but in initial intimate contact with the second physical part (6,8), it is not in intimate contact with the bulk composition, and is a grease, wax, or cured sealant.
A reactive composition for making a PIR comprising foam at an isocyanate index of at least 120, said composition comprising at least: a) An isocyanate composition comprising one or more isocyanate compounds, and b) An isocyanate-reactive composition comprising one or more isocyanate-reactive compounds, and c) At least one PIR promoting catalyst, and d) At least one physical blowing agent with a lambda gas ≤ 12 mW/m.K at 10 °C, and e) At least one CO 2 scavenging compound selected from at least one epoxy compound having an equivalent weight lower than 300g/mol, and f) Optionally a catalyst promoting epoxy reaction with CO 2 Characterized in that the amount of isocyanate-reactive compounds b) in the reactive composition is at least 10 wt% calculated on the total weight of the reactive composition or at least more than the amount of epoxy compounds, and the molar amount of epoxy compounds in the reactive composition is at least 7.8 times higher than the molar amount of CO 2 formed by the water present in the reactive composition after reaction with isocyanates. a) An isocyanate composition comprising one or more isocyanate compounds, and b) An isocyanate-reactive composition comprising one or more isocyanate-reactive compounds, and c) At least one PIR promoting catalyst, and d) At least one physical blowing agent with a lambda gas ≤ 12 mW/m.K at 10 °C, and e) At least one CO 2 scavenging compound selected from at least one epoxy compound having an equivalent weight lower than 300g/mol, and f) Optionally a catalyst promoting epoxy reaction with CO 2