A blood sampling device for alternate site blood testing, the device comprising: a thermo-conductive member (104a; 104b) configured to cool and heat a skin area; a piercing system, comprising: a piercing element configured to pierce the skin area; and a piercing mechanism for extending and retracting said skin piercing element; and an operating control unit configured to control the temperature of said thermo-conductive member (104a; 104b) and to trigger the extension of said piercing element; wherein controlling the temperature of said thermo-conductive member (104a; 104b) comprises cooling said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of -10°C -+10°C for a predetermined time, capable of blocking blood flow in capillary vessels at the skin area and of accumulating a pressure within the blocked capillary vessels, trigger the extension of said piercing element upon receiving an indication that said predetermined temperature has been reached, and heating said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of +20°C-+50°C for a predetermined time, capable of removing said blockage and of releasing the accumulated pressure in the capillary vessels and causing a boost of blood flow therein. a thermo-conductive member (104a; 104b) configured to cool and heat a skin area; a piercing system, comprising: a piercing element configured to pierce the skin area; and a piercing mechanism for extending and retracting said skin piercing element; and an operating control unit configured to control the temperature of said thermo-conductive member (104a; 104b) and to trigger the extension of said piercing element; wherein controlling the temperature of said thermo-conductive member (104a; 104b) comprises cooling said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of -10°C -+10°C for a predetermined time, capable of blocking blood flow in capillary vessels at the skin area and of accumulating a pressure within the blocked capillary vessels, trigger the extension of said piercing element upon receiving an indication that said predetermined temperature has been reached, and heating said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of +20°C-+50°C for a predetermined time, capable of removing said blockage and of releasing the accumulated pressure in the capillary vessels and causing a boost of blood flow therein. a piercing element configured to pierce the skin area; and a piercing mechanism for extending and retracting said skin piercing element; and an operating control unit configured to control the temperature of said thermo-conductive member (104a; 104b) and to trigger the extension of said piercing element; wherein controlling the temperature of said thermo-conductive member (104a; 104b) comprises cooling said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of -10°C -+10°C for a predetermined time, capable of blocking blood flow in capillary vessels at the skin area and of accumulating a pressure within the blocked capillary vessels, trigger the extension of said piercing element upon receiving an indication that said predetermined temperature has been reached, and heating said thermo-conductive member (104a; 104b) to a predetermined temperature within the range of +20°C-+50°C for a predetermined time, capable of removing said blockage and of releasing the accumulated pressure in the capillary vessels and causing a boost of blood flow therein.