A method for detecting charged biopolymer molecules, comprising: providing a nanopore device defining a nanochannel, the device comprising a first gating nanoelectrode addressing a first end of the nanochannel, a second gating nanoelectrode addressing a second end of the nanochannel opposite the first end, a first sensing nanoelectrode addressing a first location in the nanochannel between the first and second ends, and a first biopolymer probe coupled to an interior surface of the device defining the nanochannel; the first and second gating nanoelectrodes (522, 524) generating a first potential across the nanochannel to direct flow of the charged biopolymer molecules through the nanochannel from the first gating electrode to the second gating nanoelectrode; characterized in that: the first and second gating nanoelectrodes (522, 524) generating a second potential across the nanochannel to direct flow of the charged biopolymer molecules through the nanochannel from the second gating electrode to the first gating nanoelectrode; and the first and second gating nanoelectrodes (522, 524) alternatively generating the first potential and the second potential across the nanochannel to direct alternating flow of the charged biopolymer molecules through the nanochannel between the first and second gating nanoelectrodes (522, 524) to increase hybridization of the charged biopolymer molecules to the first sensing biopolymer probe. providing a nanopore device defining a nanochannel, the device comprising a first gating nanoelectrode addressing a first end of the nanochannel, a second gating nanoelectrode addressing a second end of the nanochannel opposite the first end, a first sensing nanoelectrode addressing a first location in the nanochannel between the first and second ends, and a first biopolymer probe coupled to an interior surface of the device defining the nanochannel; the first and second gating nanoelectrodes (522, 524) generating a first potential across the nanochannel to direct flow of the charged biopolymer molecules through the nanochannel from the first gating electrode to the second gating nanoelectrode; characterized in that: the first and second gating nanoelectrodes (522, 524) generating a second potential across the nanochannel to direct flow of the charged biopolymer molecules through the nanochannel from the second gating electrode to the first gating nanoelectrode; and the first and second gating nanoelectrodes (522, 524) alternatively generating the first potential and the second potential across the nanochannel to direct alternating flow of the charged biopolymer molecules through the nanochannel between the first and second gating nanoelectrodes (522, 524) to increase hybridization of the charged biopolymer molecules to the first sensing biopolymer probe. the first and second gating nanoelectrodes (522, 524) generating a second potential across the nanochannel to direct flow of the charged biopolymer molecules through the nanochannel from the second gating electrode to the first gating nanoelectrode; and the first and second gating nanoelectrodes (522, 524) alternatively generating the first potential and the second potential across the nanochannel to direct alternating flow of the charged biopolymer molecules through the nanochannel between the first and second gating nanoelectrodes (522, 524) to increase hybridization of the charged biopolymer molecules to the first sensing biopolymer probe.