A spray device comprising: a tubular body including an internal surface and first and second open ends (128, 129), first, second, and third spaced stoppers (132,134,170) in said tubular body sealingly engaging said internal surface of said tubular body and moveable within said body, said third stopper including a body portion and a projecting portion having a diameter less than said body portion; a fluid between said first and second stoppers (132,134) and a substance between said second stopper and said third stopper, said tubular body having a bypass between said second stopper and said second open end, wherein the first and second stoppers (132, 134) are initially located between the first open end and the bypass; and a spray nozzle on said second open end having a spray port, said body portion initially located within said tubular body between said second stopper and said spray nozzle and being spaced from said spray nozzle; whereby movement of said first stopper toward said second open end of said tubular body moves said second stopper to be adjacent said bypass causing said fluid to flow between said second stopper and said third stopper mixing said fluid with said substance, continued movement of said first stopper drives said second stopper against said third stopper, characterized in that continued movement of said first stopper drives said projecting portion of said third stopper against an opposed internal surface of a recess defined in said spray nozzle wherein continued movement of said third stopper compresses and deforms said projecting portion into said recess, said spray nozzle permitting the fluid under pressure in said tubular body to flow from said tubular body to said spray port through an internal passage such that said mixture of fluid and substance is forced through said spray nozzle, creating a spray suitable for inhalation by a patient. a tubular body including an internal surface and first and second open ends (128, 129), first, second, and third spaced stoppers (132,134,170) in said tubular body sealingly engaging said internal surface of said tubular body and moveable within said body, said third stopper including a body portion and a projecting portion having a diameter less than said body portion; a fluid between said first and second stoppers (132,134) and a substance between said second stopper and said third stopper, said tubular body having a bypass between said second stopper and said second open end, wherein the first and second stoppers (132, 134) are initially located between the first open end and the bypass; and a spray nozzle on said second open end having a spray port, said body portion initially located within said tubular body between said second stopper and said spray nozzle and being spaced from said spray nozzle; movement of said first stopper toward said second open end of said tubular body moves said second stopper to be adjacent said bypass causing said fluid to flow between said second stopper and said third stopper mixing said fluid with said substance, continued movement of said first stopper drives said second stopper against said third stopper, characterized in that continued movement of said first stopper drives said projecting portion of said third stopper against an opposed internal surface of a recess defined in said spray nozzle wherein continued movement of said third stopper compresses and deforms said projecting portion into said recess, said spray nozzle permitting the fluid under pressure in said tubular body to flow from said tubular body to said spray port through an internal passage such that said mixture of fluid and substance is forced through said spray nozzle, creating a spray suitable for inhalation by a patient.