A registration system for registering a group of images captured by an imaging system in a coordinate system of a medical device navigation system, comprising: an object within a field of view of the imaging system and comprising one or more fiducial markers, wherein the location of the object within the coordinate system is known and the object remains in the same known position within the coordinate system over time or moves between different known positions in the coordinate system, wherein the location of the object is known due to being in the field of view or the object is a fixed distance from a component of the navigation system or the object is connected to a sensor that is locatable in the navigation system, and wherein the object is configured to assume a first state in which the object comprising the one or more fiducial markers is visible in at least one image in the group of images and a second state in which the object comprising one or more fiducial markers is invisible in at least one image in the group of images; and an electronic control unit configured to: process at least one of the images to identify image locations of the object comprising the one or more fiducial markers in the at least one image; create a transformation model responsive to the image locations of the object comprising the plurality of fiducial markers in the at least one image and the known position in the coordinate system; and register the group of images in the coordinate system using the transformation model; wherein the object comprising one or more fiducial markers changes between the radiopaque and radiolucent state in response to exposure to at least one of electromagnetic radiation, an electrical signal, and the presence of a radiopaque dye in the anatomical region of a patient. an object within a field of view of the imaging system and comprising one or more fiducial markers, wherein the location of the object within the coordinate system is known and the object remains in the same known position within the coordinate system over time or moves between different known positions in the coordinate system, wherein the location of the object is known due to being in the field of view or the object is a fixed distance from a component of the navigation system or the object is connected to a sensor that is locatable in the navigation system, and wherein the object is configured to assume a first state in which the object comprising the one or more fiducial markers is visible in at least one image in the group of images and a second state in which the object comprising one or more fiducial markers is invisible in at least one image in the group of images; and an electronic control unit configured to: process at least one of the images to identify image locations of the object comprising the one or more fiducial markers in the at least one image; create a transformation model responsive to the image locations of the object comprising the plurality of fiducial markers in the at least one image and the known position in the coordinate system; and register the group of images in the coordinate system using the transformation model; wherein the object comprising one or more fiducial markers changes between the radiopaque and radiolucent state in response to exposure to at least one of electromagnetic radiation, an electrical signal, and the presence of a radiopaque dye in the anatomical region of a patient. process at least one of the images to identify image locations of the object comprising the one or more fiducial markers in the at least one image; create a transformation model responsive to the image locations of the object comprising the plurality of fiducial markers in the at least one image and the known position in the coordinate system; and register the group of images in the coordinate system using the transformation model; wherein the object comprising one or more fiducial markers changes between the radiopaque and radiolucent state in response to exposure to at least one of electromagnetic radiation, an electrical signal, and the presence of a radiopaque dye in the anatomical region of a patient.