An anti-transthyretin human antibody or fragment thereof, said antibody and fragment having the activity to inhibit fibrillization of TTR, wherein said human antibody: comprises the complementarity determining regions (CDRs) of an H chain consisting of the polypeptide of (a) below and the complementarity determining regions of an L chain consisting of the polypeptide of (b) below: (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or comprises the complementarity determining regions of an H chain consisting of the polypeptide of (c) below and the complementarity determining regions of an L chain consisting of the polypeptide of (d) below: (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12, and wherein said fragment thereof is a single-chain variable region of an antibody to TTR comprising a H chain variable region fragment comprising the complementarity determining regions of an H chain consisting of the polypeptide of (a) below and a L chain variable region fragment comprising the complementarity determining regions of an L chain consisting of the polypeptide of (b) below: (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or comprising a H chain variable region fragment comprising the complementarity determining regions of an H chain consisting of the polypeptide of (c) below and a L chain variable region fragment comprising the complementarity determining regions of an L chain consisting of the polypeptide of (d) below: (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7 (CDR 1), SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12. comprises the complementarity determining regions (CDRs) of an H chain consisting of the polypeptide of (a) below and the complementarity determining regions of an L chain consisting of the polypeptide of (b) below: (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or comprises the complementarity determining regions of an H chain consisting of the polypeptide of (c) below and the complementarity determining regions of an L chain consisting of the polypeptide of (d) below: (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12, and (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12, and wherein said fragment thereof is a single-chain variable region of an antibody to TTR comprising a H chain variable region fragment comprising the complementarity determining regions of an H chain consisting of the polypeptide of (a) below and a L chain variable region fragment comprising the complementarity determining regions of an L chain consisting of the polypeptide of (b) below: (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or (a) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:1; SEQ ID NO:2 and SEQ ID NO:3; (b) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6; or comprising a H chain variable region fragment comprising the complementarity determining regions of an H chain consisting of the polypeptide of (c) below and a L chain variable region fragment comprising the complementarity determining regions of an L chain consisting of the polypeptide of (d) below: (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7 (CDR 1), SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12. (c) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:7 (CDR 1), SEQ ID NO:8 and SEQ ID NO:9; (d) a polypeptide comprising the amino acid sequences as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12.