A mobile device, comprising: a memory; a wireless transceiver; and at least one processor operably coupled to the memory and the transceiver and configured to: receive assistance data for a plurality of directional positioning reference signals, PRSs, transmitted by a first base station, wherein, directing the mobile device to measure at least one first directional PRS and to not measure at least one second directional PRS of the plurality of directional PRSs because the at least one second directional PRS is not expected to be transmitted in a direction of a line of sight between the first base station and the mobile device, each of the plurality of directional PRSs includes an identification associated with a direction of transmission, wherein the at least one first directional PRS and the at least one second directional PRS from the plurality of directional PRSs are from the first base station and have different directions with each direction corresponding to a different muting sequence; identify the at least one first directional PRS to measure based at least in part on the respective identifications; and determine at least one location measurement based on the assistance data corresponding to the identified at least one first directional PRS and the corresponding muting sequence. a memory; a wireless transceiver; and at least one processor operably coupled to the memory and the transceiver and configured to: receive assistance data for a plurality of directional positioning reference signals, PRSs, transmitted by a first base station, wherein, directing the mobile device to measure at least one first directional PRS and to not measure at least one second directional PRS of the plurality of directional PRSs because the at least one second directional PRS is not expected to be transmitted in a direction of a line of sight between the first base station and the mobile device, each of the plurality of directional PRSs includes an identification associated with a direction of transmission, wherein the at least one first directional PRS and the at least one second directional PRS from the plurality of directional PRSs are from the first base station and have different directions with each direction corresponding to a different muting sequence; identify the at least one first directional PRS to measure based at least in part on the respective identifications; and determine at least one location measurement based on the assistance data corresponding to the identified at least one first directional PRS and the corresponding muting sequence. receive assistance data for a plurality of directional positioning reference signals, PRSs, transmitted by a first base station, wherein, directing the mobile device to measure at least one first directional PRS and to not measure at least one second directional PRS of the plurality of directional PRSs because the at least one second directional PRS is not expected to be transmitted in a direction of a line of sight between the first base station and the mobile device, each of the plurality of directional PRSs includes an identification associated with a direction of transmission, wherein the at least one first directional PRS and the at least one second directional PRS from the plurality of directional PRSs are from the first base station and have different directions with each direction corresponding to a different muting sequence; identify the at least one first directional PRS to measure based at least in part on the respective identifications; and determine at least one location measurement based on the assistance data corresponding to the identified at least one first directional PRS and the corresponding muting sequence.