A Controller Area Network, CAN, circuit structure, comprising: a pair of data buses on which differential signals are transmitted; a CAN transceiver operating in a first voltage domain, wherein the CAN transceiver is connected to the data buses for receiving and transmitting the differential signals; a clamp circuit disposed between the CAN transceiver and the data buses for clamping a high level or a low level of the differential signals, so that a difference between voltages of the differential signals is adapted to the CAN transceiver, wherein the clamp circuit is configured to restrict the low level of the differential signals to a ground terminal of the first voltage domain and the high level of the differential signals to an operating voltage of the first voltage domain; a CAN controller operating in a second voltage domain, wherein the CAN controller is connected to the CAN transceiver for communicating with the CAN transceiver; and a signal isolation circuit disposed between the CAN transceiver and the CAN controller for isolating the first voltage domain from the second voltage domain, wherein a first connection terminal of the signal isolation circuit is connected to the CAN transceiver and a second connection terminal of the signal isolation circuit is connected to the CAN controller for isolating and converting a signal transmitted between the first voltage domain and the second voltage domain; further comprising: a power supply circuit configured to provide the first voltage domain and the second voltage domain for the CAN transceiver and the CAN controller; wherein the power supply circuit forms a first ground terminal and a second ground terminal that are isolated from each other and outputs a first supply voltage and a second supply voltage, wherein the CAN transceiver is connected to the first supply voltage and the first ground terminal and the CAN controller is connected to the second supply voltage and the second ground terminal; characterised in that the power supply circuit comprises an input power supply and an isolated power supply, wherein an input terminal of the isolated power supply is connected to the input power supply, and an output terminal of the isolated power supply forms the first supply voltage and the first ground terminal and the isolated power supply is connected to the CAN transceiver for providing the first supply voltage and the first ground terminal for the CAN transceiver. a pair of data buses on which differential signals are transmitted; a CAN transceiver operating in a first voltage domain, wherein the CAN transceiver is connected to the data buses for receiving and transmitting the differential signals; a clamp circuit disposed between the CAN transceiver and the data buses for clamping a high level or a low level of the differential signals, so that a difference between voltages of the differential signals is adapted to the CAN transceiver, wherein the clamp circuit is configured to restrict the low level of the differential signals to a ground terminal of the first voltage domain and the high level of the differential signals to an operating voltage of the first voltage domain; a CAN controller operating in a second voltage domain, wherein the CAN controller is connected to the CAN transceiver for communicating with the CAN transceiver; and a signal isolation circuit disposed between the CAN transceiver and the CAN controller for isolating the first voltage domain from the second voltage domain, wherein a first connection terminal of the signal isolation circuit is connected to the CAN transceiver and a second connection terminal of the signal isolation circuit is connected to the CAN controller for isolating and converting a signal transmitted between the first voltage domain and the second voltage domain; further comprising: a power supply circuit configured to provide the first voltage domain and the second voltage domain for the CAN transceiver and the CAN controller; wherein the power supply circuit forms a first ground terminal and a second ground terminal that are isolated from each other and outputs a first supply voltage and a second supply voltage, wherein the CAN transceiver is connected to the first supply voltage and the first ground terminal and the CAN controller is connected to the second supply voltage and the second ground terminal; characterised in that the power supply circuit comprises an input power supply and an isolated power supply, wherein an input terminal of the isolated power supply is connected to the input power supply, and an output terminal of the isolated power supply forms the first supply voltage and the first ground terminal and the isolated power supply is connected to the CAN transceiver for providing the first supply voltage and the first ground terminal for the CAN transceiver.