A compound having structural Formula I or a pharmaceutically acceptable salt thereof wherein: Z is X 1 X 2, X 3 and X 4 are each independently selected from C(R 4) and N, provided that at least one and at most two of X 1, X 2, X 3 and X 4 are N; R 1 is -H, halo, -OH, or -OC 1-3 alkyl; R 2 is -H, =O, -OH, -C 1-3 alkyl or -OC 1-3 alkyl; R 3a is -H,-C 3-4 cycloalkyl or -C 1-3 alkyl optionally substituted with -OCH 3 or 1 to 3 of -F; R 3b is -H or -C 1-3 alkyl, or R 3b is absent when the dashed bond is a double bond; or R 3a and R 3b are joined together with the carbon to which they are both attached to form cyclopropyl or cyclobutyl; each R 4 is independently -H, halo, -CN, -C 3-6 cycloalkyl, -C OC 1-4 alkyl, -OC 1-4 alkyl, or -C 1-4 alkyl optionally substituted with OH or 1-3 of -F; R 5 is -H, halo, or -C 1-3 alkyl optionally substituted with -O-C 1-3 alkyl; R 6 is -H or -C 1-3 alkyl; R 7 is -H or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F, or R 7 is absent when n is zero; R 8 is -H or -C 1-3 alkyl, or R 8 is absent when n is zero; or R 7 and R 8 are joined together with the carbon to which they are both attached to form cyclopropyl or cyclobutyl; R 9 is -H, halo, -OH, -C 1-3 alkyl, -OC 1-3 alkyl or -CH 2 OH; R 10 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3, or 1 to 3 of -F; R 11 is -H, or - C 1-3 alkyl optionally substituted with -OH, -OCH 3, or 1 to 3 of -F; or R 10 and R 11 are joined together to represent -CH 2 -CH 2 -, -CH 2 -N(CH 3)-CH 2 - or -CH 2 OCH 2 -; R 12, R 13 and R 14 are each independently -H, halo, -CN, -C 3-6 cycloalkyl, -C OC 1-4 alkyl, -OC 1-4 alkyl, or - C 1-4 alkyl optionally substituted with -OH or 1-3 of -F; m is zero where R 3b is absent, or one where R 3b is present; the partially dashed double bond (" - - - ") represents a single or double bond wherein: (i) when m is one, then the dashed bond is a single bond; and (ii) when m is zero and R 2 is not =O, then the dashed bond is a double bond; and n is zero or one. Z is X 1 X 2, X 3 and X 4 are each independently selected from C(R 4) and N, provided that at least one and at most two of X 1, X 2, X 3 and X 4 are N; R 1 is -H, halo, -OH, or -OC 1-3 alkyl; R 2 is -H, =O, -OH, -C 1-3 alkyl or -OC 1-3 alkyl; R 3a is -H,-C 3-4 cycloalkyl or -C 1-3 alkyl optionally substituted with -OCH 3 or 1 to 3 of -F; R 3b is -H or -C 1-3 alkyl, or R 3b is absent when the dashed bond is a double bond; or R 3a and R 3b are joined together with the carbon to which they are both attached to form cyclopropyl or cyclobutyl; each R 4 is independently -H, halo, -CN, -C 3-6 cycloalkyl, -C OC 1-4 alkyl, -OC 1-4 alkyl, or -C 1-4 alkyl optionally substituted with OH or 1-3 of -F; R 5 is -H, halo, or -C 1-3 alkyl optionally substituted with -O-C 1-3 alkyl; R 6 is -H or -C 1-3 alkyl; R 7 is -H or -C 1-3 alkyl optionally substituted with -OH, -OCH 3 or 1 to 3 of -F, or R 7 is absent when n is zero; R 8 is -H or -C 1-3 alkyl, or R 8 is absent when n is zero; or R 7 and R 8 are joined together with the carbon to which they are both attached to form cyclopropyl or cyclobutyl; R 9 is -H, halo, -OH, -C 1-3 alkyl, -OC 1-3 alkyl or -CH 2 OH; R 10 is -H, or -C 1-3 alkyl optionally substituted with -OH, -OCH 3, or 1 to 3 of -F; R 11 is -H, or - C 1-3 alkyl optionally substituted with -OH, -OCH 3, or 1 to 3 of -F; or R 10 and R 11 are joined together to represent -CH 2 -CH 2 -, -CH 2 -N(CH 3)-CH 2 - or -CH 2 OCH 2 -; R 12, R 13 and R 14 are each independently -H, halo, -CN, -C 3-6 cycloalkyl, -C OC 1-4 alkyl, -OC 1-4 alkyl, or - C 1-4 alkyl optionally substituted with -OH or 1-3 of -F; m is zero where R 3b is absent, or one where R 3b is present; the partially dashed double bond (" - - - ") represents a single or double bond wherein: (i) when m is one, then the dashed bond is a single bond; and (ii) when m is zero and R 2 is not =O, then the dashed bond is a double bond; and (i) when m is one, then the dashed bond is a single bond; and (ii) when m is zero and R 2 is not =O, then the dashed bond is a double bond; and n is zero or one.