A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar 1 is Ar 1 is optionally substituted with w occurrences of -W-R W; wherein W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by -CO-, -O-, -S-, -SO 2 -, or -NR'-; R' is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; and R W is independently H, halo, CN, NO 2, NH 2, CF 3, OCF 3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, aryl, or heteroaryl, wherein, when substituted, R W is substituted with up to two R 2; R 2 is halo, CN, NO 2, CF 3, OCF 3, OR, -(C1-C6)alkylidene-OH, -(C1-C6)alkylidene-N 2, OC R, OC N 2, SR, S R, SO 2 R, SO 2 N 2, SO 3 R, C R, CO 2 R, C N 2, N 2, NRC R, NRCO 2 R, NRC N 2, NRSO 2 R, B 2, or NRSO 2 N 2; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; R N is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; A is an optionally substuted 3-7 membered monocyclic ring; B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl; J is selected from the group consisting of CH 2, CF 2, C(CH 3) 2, C, C(Phenyl) 2, B, and CH(OEt); and w is independently an integer from 0 to 5 inclusive. Ar 1 is Ar 1 is optionally substituted with w occurrences of -W-R W; wherein W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by -CO-, -O-, -S-, -SO 2 -, or -NR'-; R' is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; and R W is independently H, halo, CN, NO 2, NH 2, CF 3, OCF 3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, aryl, or heteroaryl, wherein, when substituted, R W is substituted with up to two R 2; R 2 is halo, CN, NO 2, CF 3, OCF 3, OR, -(C1-C6)alkylidene-OH, -(C1-C6)alkylidene-N 2, OC R, OC N 2, SR, S R, SO 2 R, SO 2 N 2, SO 3 R, C R, CO 2 R, C N 2, N 2, NRC R, NRCO 2 R, NRC N 2, NRSO 2 R, B 2, or NRSO 2 N 2; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by -CO-, -O-, -S-, -SO 2 -, or -NR'-; R' is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; and R W is independently H, halo, CN, NO 2, NH 2, CF 3, OCF 3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, aryl, or heteroaryl, wherein, when substituted, R W is substituted with up to two R 2; R 2 is halo, CN, NO 2, CF 3, OCF 3, OR, -(C1-C6)alkylidene-OH, -(C1-C6)alkylidene-N 2, OC R, OC N 2, SR, S R, SO 2 R, SO 2 N 2, SO 3 R, C R, CO 2 R, C N 2, N 2, NRC R, NRCO 2 R, NRC N 2, NRSO 2 R, B 2, or NRSO 2 N 2; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; R N is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; A is an optionally substuted 3-7 membered monocyclic ring; B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl; J is selected from the group consisting of CH 2, CF 2, C(CH 3) 2, C, C(Phenyl) 2, B, and CH(OEt); and w is independently an integer from 0 to 5 inclusive.