Method for detecting a target moiety in a sample of biological specimens by providing a conjugate with the general formula With Ar, MU and L1 as repeating units of a polymer Ar is a aryl or heteroaryl group, MU is a polymer modifying unit or band gap modifying unit that is evenly or randomly distributed along the polymer main chain, L1 is an aryl or a heteroaryl group evenly or randomly distributed along the polymer, L2 is an aryl or a heteroaryl group located on the ends of the polymer, FL is a fluorescent moiety, G1 and G2 stand for hydrogen, halogen or an antigen recognizing moiety, with the provision than at least one of G1 or G2 is an antigen recognizing moiety, and a is 10 to 100 mol %, b is 0,1 to 50 mol % c is 0 to 90 mol % d is 1 to 10,000 with the provisio that a + b + c = 100 mol% characterized in a) contacting the sample of biological specimens with at least one conjugate, thereby labeling the target moiety recognized by an antigen recognizing moiety with the conjugate; b) exciting the labelled target moieties with light having a wavelength within the absorbance spectrum of the fluorescent moiety FL; c) detecting the labelled target moieties by detecting the fluorescence radiation emitted by the fluorescent moiety FL and d) degrading the fluorescent moiety FL of the labelled target moieties by irradiating the conjugate with light having a wavelength within the absorbance spectrum of fluorescent moiety FL for a time sufficient to deliver enough energy to reduce the fluorescence radiation emitted by the fluorescent moiety FL at least by 75 % of the initial fluorescence radiation. With Ar, MU and L1 as repeating units of a polymer Ar is a aryl or heteroaryl group, MU is a polymer modifying unit or band gap modifying unit that is evenly or randomly distributed along the polymer main chain, L1 is an aryl or a heteroaryl group evenly or randomly distributed along the polymer, L2 is an aryl or a heteroaryl group located on the ends of the polymer, FL is a fluorescent moiety, G1 and G2 stand for hydrogen, halogen or an antigen recognizing moiety, with the provision than at least one of G1 or G2 is an antigen recognizing moiety, and a is 10 to 100 mol %, b is 0,1 to 50 mol % c is 0 to 90 mol % d is 1 to 10,000 a is 10 to 100 mol %, b is 0,1 to 50 mol % c is 0 to 90 mol % d is 1 to 10,000 with the provisio that a + b + c = 100 mol% characterized in a) contacting the sample of biological specimens with at least one conjugate, thereby labeling the target moiety recognized by an antigen recognizing moiety with the conjugate; b) exciting the labelled target moieties with light having a wavelength within the absorbance spectrum of the fluorescent moiety FL; c) detecting the labelled target moieties by detecting the fluorescence radiation emitted by the fluorescent moiety FL and d) degrading the fluorescent moiety FL of the labelled target moieties by irradiating the conjugate with light having a wavelength within the absorbance spectrum of fluorescent moiety FL for a time sufficient to deliver enough energy to reduce the fluorescence radiation emitted by the fluorescent moiety FL at least by 75 % of the initial fluorescence radiation. a) contacting the sample of biological specimens with at least one conjugate, thereby labeling the target moiety recognized by an antigen recognizing moiety with the conjugate; b) exciting the labelled target moieties with light having a wavelength within the absorbance spectrum of the fluorescent moiety FL; c) detecting the labelled target moieties by detecting the fluorescence radiation emitted by the fluorescent moiety FL and d) degrading the fluorescent moiety FL of the labelled target moieties by irradiating the conjugate with light having a wavelength within the absorbance spectrum of fluorescent moiety FL for a time sufficient to deliver enough energy to reduce the fluorescence radiation emitted by the fluorescent moiety FL at least by 75 % of the initial fluorescence radiation.