mhurhangee/ep-ind-claims huggingface dataset:
A method for plasmid-free producing a recombinant protein of interest, comprising the steps of a) cultivating a population of bacterial expression host cells which are Escherichia coli (Ecoli) cells, b) harvesting the protein of interest, and c) isolating and purifying it, wherein in step a), cultivation is in a mode that employs the addition of a feeding medium, said mode being selected from the fed-batch, semi-continuous or continuous mode, wherein a DNA construct comprising one or two copies of a gene of interest is integrated at a preselected locus in the bacterial genome of the expression host cells or wherein two DNA constructs comprising a gene of interest are integrated at a preselected locus in the bacterial genome of the expression host cell, said gene of interest encoding the protein of interest being under the control of a promoter that enables expression of said protein, and wherein said bacterial expression host cells contain a T7 RNA polymerase gene in their genome and wherein said promoter is the T7 promoter. a) cultivating a population of bacterial expression host cells which are Escherichia coli (Ecoli) cells, b) harvesting the protein of interest, and c) isolating and purifying it,
A method for dynamic access network selection by a user equipment based on application orchestration information in an edge cloud system, the method comprising: transmitting, by a network discovery function, an application orchestration information request to an interface of a central data center of the edge cloud system, wherein the application orchestration information request includes an identifier of an application such that the application orchestration information includes identifiers of each data center in the edge cloud system in which an instance of the application is placed; receiving the application orchestration information transmitted to the network discovery function in response to the application orchestration information request; determining, by the network discovery function, application orchestration information describing placement of instances of one or more applications in the edge cloud system; generating, by the network discovery function, one or more access network policies for the user equipment based on the application orchestration information; and transmitting, by the network discovery function, the one or more access network policies to the user equipment such that, based on the one or more access network policies, the user equipment is to select one or more of an access network from a plurality of access networks available to the user equipment for the user equipment to connect to and which access network from the plurality of access networks to route particular data flows. transmitting, by a network discovery function, an application orchestration information request to an interface of a central data center of the edge cloud system, wherein the application orchestration information request includes an identifier of an application such that the application orchestration information includes identifiers of each data center in the edge cloud system in which an instance of the application is placed; receiving the application orchestration information transmitted to the network discovery function in response to the application orchestration information request; determining, by the network discovery function, application orchestration information describing placement of instances of one or more applications in the edge cloud system; generating, by the network discovery function, one or more access network policies for the user equipment based on the application orchestration information; and transmitting, by the network discovery function, the one or more access network policies to the user equipment such that, based on the one or more access network policies, the user equipment is to select one or more of an access network from a plurality of access networks available to the user equipment for the user equipment to connect to and which access network from the plurality of access networks to route particular data flows.
A method for braking a translator (110, 120) of a linear multiphase electromagnetic machine for reciprocating operation, the method comprising: detecting, using circuitry, a fault event and causing the translator to brake by causing the translator to achieve a reduced position-velocity trajectory, wherein the translator translates according to a first trajectory comprising a first apex position, and wherein the reduced position-velocity trajectory comprises a second apex position, and wherein the second apex is closer to a mid-stroke position than the first apex position; and in response to detecting the fault event, causing, using an electromagnetic technique associated with one or more phases of a stator (152, 157) of the linear multiphase electromagnetic machine, the translator of the linear multiphase electromagnetic machine to brake. detecting, using circuitry, a fault event and causing the translator to brake by causing the translator to achieve a reduced position-velocity trajectory, wherein the translator translates according to a first trajectory comprising a first apex position, and wherein the reduced position-velocity trajectory comprises a second apex position, and wherein the second apex is closer to a mid-stroke position than the first apex position; and in response to detecting the fault event, causing, using an electromagnetic technique associated with one or more phases of a stator (152, 157) of the linear multiphase electromagnetic machine, the translator of the linear multiphase electromagnetic machine to brake.
An apparatus comprising: a first earpiece configured to receive audio signals from an external source device; a first near field magnetic induction, NFMI, radio at the first earpiece configured to convert the received audio signals to NFMI signals; and a first electro-acoustic transducer comprising a first coil at the first earpiece and a second electro-acoustic transducer at a second earpiece comprising a second coil of the apparatus, wherein the first electro-acoustic transducer is configured to transmit the NFMI signals to the second earpiece of the apparatus via magnetic coupling of the first electro-acoustic transducer and the second electro-acoustic transducer and wherein the first earpiece processes the audio signals and the second earpiece processes the NFMI signals by a second NFMI radio at the second earpiece so that first and second electro-acoustic transducers output representations of the audio signals via mechanical vibrations. a first earpiece configured to receive audio signals from an external source device; a first near field magnetic induction, NFMI, radio at the first earpiece configured to convert the received audio signals to NFMI signals; and a first electro-acoustic transducer comprising a first coil at the first earpiece and a second electro-acoustic transducer at a second earpiece comprising a second coil of the apparatus, wherein the first electro-acoustic transducer is configured to transmit the NFMI signals to the second earpiece of the apparatus via magnetic coupling of the first electro-acoustic transducer and the second electro-acoustic transducer and wherein the first earpiece processes the audio signals and the second earpiece processes the NFMI signals by a second NFMI radio at the second earpiece so that first and second electro-acoustic transducers output representations of the audio signals via mechanical vibrations.
A computer implemented method of radiotherapy treatment plan optimization using a scenario-based optimization function to perform optimization based on at least a first and a second scenario, each scenario representing the realization of at least one uncertainty related to the position of at least one region of interest, the method comprising the steps of: - providing input data for the optimization; - defining at least a first and a second scenario, the first and second scenario representing a first and a second realization, respectively, of the at least one uncertainty, including a first and a second possible location (3", 5') of the region of interest (3, 5); - identifying the extent of the region of interest in the first scenario and in the second scenario; - defining the extended region of interest volume based on the union of the extent of the region of interest in the first and the second scenario; - optimizing a radiotherapy treatment plan using the extended region of interest volume. - providing input data for the optimization; - defining at least a first and a second scenario, the first and second scenario representing a first and a second realization, respectively, of the at least one uncertainty, including a first and a second possible location (3", 5') of the region of interest (3, 5); - identifying the extent of the region of interest in the first scenario and in the second scenario; - defining the extended region of interest volume based on the union of the extent of the region of interest in the first and the second scenario; - optimizing a radiotherapy treatment plan using the extended region of interest volume.
A linker unit comprising, a center core and a plurality of linking arms, wherein the center core comprises a first polypeptide comprising a plurality of lysine residues, wherein each K residue and its next K residue are separated by a filler sequence comprising glycine and serine residues, and the number of K residues ranges from 2 to 15; each of the plurality of linking arms has an N-hydroxysuccinimidyl group at one end and a functional group at the other end and is linked to one of the K residues of the center core by forming an amide bond between the amine group of the K residue and the NHS group, wherein each of the linking arms is a PEG chain having 2-20 repeats of EG units and the functional group is a NHS; and the amino acid residue at the N- or C-terminus of the center core has the azide or the alkyne group. the center core comprises a first polypeptide comprising a plurality of lysine residues, wherein each K residue and its next K residue are separated by a filler sequence comprising glycine and serine residues, and the number of K residues ranges from 2 to 15; each of the plurality of linking arms has an N-hydroxysuccinimidyl group at one end and a functional group at the other end and is linked to one of the K residues of the center core by forming an amide bond between the amine group of the K residue and the NHS group, wherein each of the linking arms is a PEG chain having 2-20 repeats of EG units and the functional group is a NHS; and the amino acid residue at the N- or C-terminus of the center core has the azide or the alkyne group.
Method for classifying the status of the winding clamping of a power transformer which is immersed in an oil filled transformer tank, wherein the power transformer comprises at least one transformer coil (16, 18, 20) with at least one clamped (102 ⇔ 104) electrical winding arranged on a transformer core, the method comprising the following steps: • applying a mechanical force impulse on an impact area (28, 30, 32, 34) of the transformer tank, so that the at least winding is mechanically excited to vibration and a voltage is induced (40, 42, 44, 52) within the at least one winding therewith, • measuring the induced voltage (40, 42, 44, 52) of the at least one winding for a period of time during vibration, transferring those measurement data from the time domain into the frequency domain and providing a respective dataset comprising the measurement data in the frequency domain, • searching for local maxima (88, 90, 92) within the measurement data in the frequency domain of the dataset, characterized by the following steps: • classifying the status of the winding clamping of the at least one winding as defective in case that there is no distinct maximum within the local maxima, • classifying the status of the winding clamping of the at least one winding as at least possibly sufficient in case that there is exactly one distinct maximum within the local maxima. • applying a mechanical force impulse on an impact area (28, 30, 32, 34) of the transformer tank, so that the at least winding is mechanically excited to vibration and a voltage is induced (40, 42, 44, 52) within the at least one winding therewith, • measuring the induced voltage (40, 42, 44, 52) of the at least one winding for a period of time during vibration, transferring those measurement data from the time domain into the frequency domain and providing a respective dataset comprising the measurement data in the frequency domain, • searching for local maxima (88, 90, 92) within the measurement data in the frequency domain of the dataset, • classifying the status of the winding clamping of the at least one winding as defective in case that there is no distinct maximum within the local maxima, • classifying the status of the winding clamping of the at least one winding as at least possibly sufficient in case that there is exactly one distinct maximum within the local maxima.
A method for inspecting a heating member (9, 10) being part of a cartridge of a device for generating inhalable vapours (2, 3) from a vaporizable liquid product, the method including the following steps: - processing an acquired image, being obtained by framing the heating member (9, 10); - identifying in the processed image a first closed region being associable to a first group of contact coils of a heating element being wound in coils about a wick, the first group of contact coils representing a first contact terminal configured to contact a respective first power electrode of the cartridge; - identifying in the processed image a second closed region being associable to a second group of contact coils of the heating element, the second group of contact coils representing a second contact terminal configured to contact a respective second power electrode of the cartridge; - calculating for the first closed region a respective first reference centre of the coils and calculating for the second closed region a respective second reference centre of the coils; - calculating a reference centre of the heating member (9, 10) being arranged between the first group of contact coils and the second group of contact coils, starting from the first reference centre of the coils and from the second reference centre of the coils, in order to use the reference centre of the heating member to be able to precisely couple the first and second terminal of the heating member (9, 10), during a production step of the cartridge, respectively to the first power electrode of the cartridge and the second power electrode of the cartridge. - processing an acquired image, being obtained by framing the heating member (9, 10); - identifying in the processed image a first closed region being associable to a first group of contact coils of a heating element being wound in coils about a wick, the first group of contact coils representing a first contact terminal configured to contact a respective first power electrode of the cartridge; - identifying in the processed image a second closed region being associable to a second group of contact coils of the heating element, the second group of contact coils representing a second contact terminal configured to contact a respective second power electrode of the cartridge; - calculating for the first closed region a respective first reference centre of the coils and calculating for the second closed region a respective second reference centre of the coils; - calculating a reference centre of the heating member (9, 10) being arranged between the first group of contact coils and the second group of contact coils, starting from the first reference centre of the coils and from the second reference centre of the coils, in order to use the reference centre of the heating member to be able to precisely couple the first and second terminal of the heating member (9, 10), during a production step of the cartridge, respectively to the first power electrode of the cartridge and the second power electrode of the cartridge.
A propionyl-CoA transferase supplying lactyl-CoA, which has a gene sequence of SEQ ID NO: 3, in which A1200G is mutated, wherein the propionyl-CoA transferase has a) a gene sequence of SEQ ID NO: 3, in which A1200G is mutated; b) a gene sequence of SEQ ID NO: 3, in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Gly335Asp; c) a gene sequence of SEQ ID NO: 3 in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Ala243Thr; or d) a gene sequence of SEQ ID NO: 3 in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Asp257Asn. a) a gene sequence of SEQ ID NO: 3, in which A1200G is mutated; b) a gene sequence of SEQ ID NO: 3, in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Gly335Asp; c) a gene sequence of SEQ ID NO: 3 in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Ala243Thr; or d) a gene sequence of SEQ ID NO: 3 in which A1200G is mutated and at least one mutation of the nucleic acid is further introduced to cause mutation of Asp257Asn.
An eye surgical lighting unit for lighting internal ocular tissue, comprising a fiber having a proximal end and a distal end, for guiding a light beam to the distal end, wherein the lighting unit furthermore comprises a manual unit, provided with a cannula and a handle designed, through manual operation thereof, to bring the distal end of the fiber in a desired position and/or orientation within the eye, the handle having an internal passage positioned in line with the cannula, wherein the fiber is adjustable between an intraocular operational position in which the fiber extends through the internal passage of the handle and through the cannula, and a chandelier operational position in which the fiber is uncoupled from the manual unit.
A wound guard comprising a disc portion having a contact surface for contacting the surface of the skin of a patient and a second surface disposed away from the contact surface, and a projection which projects away from the second surface, wherein said projection has a bore passing through the projection to said first surface, said projection being adapted to hold a transdermal device, in use, in said bore, wherein the wound guard is impregnated with a first antimicrobial agent and wherein the first antimicrobial agent is triclosan, wherein the wound guard is impregnated with a second antimicrobial agent, such that a microbe that mutates to be resistant to one of the first and second antimicrobial agents will not be resistant to the other of the first and second antimicrobial agents, wherein the second antimicrobial agent is rifamycin, rifampin, lincomycin or clindamycin.
A computer-implemented method for autonomously testing a logical model for inconsistencies, the method comprising: retrieving metadata descriptive of a logical model, wherein the logical model comprises an abstraction for a database schema, the database schema is implemented at a database, and the database schema comprises a fact table and one or more dimension tables; automatically generating a plurality of logical queries comprising at least a first logical query and a second logical query based on the retrieved metadata, wherein the first logical query and second logical query target a logical object of the logical model; issuing at least the first logical query and the second logical query to a server that hosts the logical model, wherein, at the server, the first logical query is translated to a first database query and the second logical query is translated to a second database query, and the first database query and second database query target at least a fact table and a dimension table from the database schema; comparing query results received from execution of the first database query and second database query; and identifying one or more inconsistencies when the comparison of the query results for the first database query and second database query does not meet a criterion, wherein the one or more inconsistencies comprise an inconsistency with the logical model as defined by the metadata or an inconsistency at the database. retrieving metadata descriptive of a logical model, wherein the logical model comprises an abstraction for a database schema, the database schema is implemented at a database, and the database schema comprises a fact table and one or more dimension tables; automatically generating a plurality of logical queries comprising at least a first logical query and a second logical query based on the retrieved metadata, wherein the first logical query and second logical query target a logical object of the logical model; issuing at least the first logical query and the second logical query to a server that hosts the logical model, wherein, at the server, the first logical query is translated to a first database query and the second logical query is translated to a second database query, and the first database query and second database query target at least a fact table and a dimension table from the database schema; comparing query results received from execution of the first database query and second database query; and identifying one or more inconsistencies when the comparison of the query results for the first database query and second database query does not meet a criterion, wherein the one or more inconsistencies comprise an inconsistency with the logical model as defined by the metadata or an inconsistency at the database.
A method of transmitting channel reservation signals for a radio access technology, RAT, that supports different numerologies, the method comprising: using a gating interval to gain access to a channel of a shared spectrum; performing a clear channel assessment to determine if the channel is available; selecting a channel reservation signal from amongst a plurality of predetermined channel reservation signals if the channel is clear, wherein each of the plurality of predetermined channel reservation signals comprises: a channel reservation preamble, wherein the channel reservation preamble for each of the plurality of predetermined channel reservation signals is the same irrespective of numerology used by the RAT; and multiple copies of a channel reservation message, each copy corresponding to a different numerology supported by the RAT; and transmitting the channel reservation signal if the channel is clear. using a gating interval to gain access to a channel of a shared spectrum; performing a clear channel assessment to determine if the channel is available; selecting a channel reservation signal from amongst a plurality of predetermined channel reservation signals if the channel is clear, wherein each of the plurality of predetermined channel reservation signals comprises: a channel reservation preamble, wherein the channel reservation preamble for each of the plurality of predetermined channel reservation signals is the same irrespective of numerology used by the RAT; and multiple copies of a channel reservation message, each copy corresponding to a different numerology supported by the RAT; and a channel reservation preamble, wherein the channel reservation preamble for each of the plurality of predetermined channel reservation signals is the same irrespective of numerology used by the RAT; and multiple copies of a channel reservation message, each copy corresponding to a different numerology supported by the RAT; and transmitting the channel reservation signal if the channel is clear.