mhurhangee/ep-ind-claims huggingface dataset:
Circuit arrangement for controlling a power semiconductor switch, the switch comprising a gate terminal, a source terminal and a drain terminal with a conduction channel being formed between the source and drain terminals (S, D), the circuit arrangement comprising: - means for generating a control signal by which the semiconductor switch is alternated between a turned-on state and a turned-off state; - a current source for injecting a current into the gate terminal; - an evaluation unit arranged to: -- measure the voltage between the gate terminal and one of the source terminal and drain terminal (S, D) while the semiconductor switch is in the turned-on state, -- determine from the measured voltage and the current from the current source the absolute temperature of the semiconductor switch. - means for generating a control signal by which the semiconductor switch is alternated between a turned-on state and a turned-off state; - a current source for injecting a current into the gate terminal; - an evaluation unit arranged to: -- measure the voltage between the gate terminal and one of the source terminal and drain terminal (S, D) while the semiconductor switch is in the turned-on state, -- determine from the measured voltage and the current from the current source the absolute temperature of the semiconductor switch. -- measure the voltage between the gate terminal and one of the source terminal and drain terminal (S, D) while the semiconductor switch is in the turned-on state, -- determine from the measured voltage and the current from the current source the absolute temperature of the semiconductor switch.
Method for controlling a fuel/air ratio in a heating system, which method comprises the following steps: • generating a temporary, new fluid supply change in a fluid supply characteristic variable with respect to time depending on a last signal maximum, • ascertaining a new signal maximum of a change in at least one combustion characteristic variable with respect to time which is correlated with the new fluid supply change with respect to time, • increasing a fault variable if the new signal maximum undershoots a signal lower limit, • executing a response to a fault, in particular calibrating and/or shutting down the heating system, depending on the fault variable. • generating a temporary, new fluid supply change in a fluid supply characteristic variable with respect to time depending on a last signal maximum, • ascertaining a new signal maximum of a change in at least one combustion characteristic variable with respect to time which is correlated with the new fluid supply change with respect to time, • increasing a fault variable if the new signal maximum undershoots a signal lower limit, • executing a response to a fault, in particular calibrating and/or shutting down the heating system, depending on the fault variable.
A prosthesis fixation system comprising: a delivery device having a distal end and a proximal end, the delivery device comprising an inner cannula extending between the distal end and the proximal end of the delivery device, a positioner disposed coaxially over a first portion of the inner cannula, and a tip assembly attached to a proximal end of the inner cannula; a prosthesis releasably coupled to the delivery device at the proximal end of the delivery device; at least one trigger wire extending longitudinally within a lumen of the positioner; and at least one suture loop attached to the proximal end of the positioner, wherein a proximal end of the at least one trigger wire extends proximally beyond the proximal end of the positioner such that the at least one trigger wire passes through the at least one suture loop and is removably attached to an end of the prosthesis for releasably coupling the end of the prosthesis to the delivery device. a delivery device having a distal end and a proximal end, the delivery device comprising an inner cannula extending between the distal end and the proximal end of the delivery device, a positioner disposed coaxially over a first portion of the inner cannula, and a tip assembly attached to a proximal end of the inner cannula; a prosthesis releasably coupled to the delivery device at the proximal end of the delivery device; at least one trigger wire extending longitudinally within a lumen of the positioner; and at least one suture loop attached to the proximal end of the positioner, wherein a proximal end of the at least one trigger wire extends proximally beyond the proximal end of the positioner such that the at least one trigger wire passes through the at least one suture loop and is removably attached to an end of the prosthesis for releasably coupling the end of the prosthesis to the delivery device.
A computer-implemented method of analyzing a biological sample of an organism for deletions or amplifications in one or more chromosomal regions associated with cancer, the biological sample including cell-free DNA molecules originating from non-malignant cells and potentially from tumor cells associated with cancer, the method comprising: receiving sequenced tags obtained from a random sequencing of DNA molecules contained in the biological sample, the biological sample being plasma, serum, saliva, or urine; aligning a plurality of the sequenced tags to a reference human genome; determining a first amount from sequenced tags identified as aligning to a first chromosomal region that is part of a first chromosome; determining a second amount from sequenced tags identified as aligning to one or more second chromosomal regions; determining a first parameter from the first amount and the second amount, wherein the parameter includes a ratio between the first amount and the second amount, wherein an aberration in the first parameter for the first chromosomal region is associated with cancer; and comparing the first parameter to one or more cutoff values to determine a classification of whether the first chromosomal region exhibits a deletion and/or an amplification associated with cancer. receiving sequenced tags obtained from a random sequencing of DNA molecules contained in the biological sample, the biological sample being plasma, serum, saliva, or urine; aligning a plurality of the sequenced tags to a reference human genome; determining a first amount from sequenced tags identified as aligning to a first chromosomal region that is part of a first chromosome; determining a second amount from sequenced tags identified as aligning to one or more second chromosomal regions; determining a first parameter from the first amount and the second amount, wherein the parameter includes a ratio between the first amount and the second amount, wherein an aberration in the first parameter for the first chromosomal region is associated with cancer; and comparing the first parameter to one or more cutoff values to determine a classification of whether the first chromosomal region exhibits a deletion and/or an amplification associated with cancer.
Use of one or more compounds of the formula in which R is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atoms as fungicide. R is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atoms
Amusement device comprising a base structure, an arm constrained at least rotationally to said base structure, a rotating structure provided with at least one vehicle and rotatably constrained with respect to one end of said arm, around a rotation axis, movement means constrained between said base structure and said arm for moving said arm between at least a first load position in which passengers are loaded, and a second rotation position of said rotating structure, said arm comprising at least two portions (31, 32) mutually movable, said first portion of said arm being rotationally constrained to said base structure, said second portion of said arm being constrained to said rotating structure, wherein, in said load position, said arm portions are completely comprised in a cylinder having an axis that is said rotation axis, and having a radius that is the distance from said at least one vehicle to said rotation axis, characterised in that said movement means is constrained to the said second portion of said arm constrained in turn to said rotating structure.
A polypeptide consisting of no more than 100 amino acids, which polypeptide comprises one or more sequences of SEQ ID NO: 3 and/or one or more sequences having at least 85% homology with the 21 amino acid sequence of SEQ ID NO: 3: SEQ ID NO: 3 DLIFLARSALILRGSVAHKSC wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex allele, and wherein the polypeptide is immunogenic to a plurality of influenza virus strains. SEQ ID NO: 3 DLIFLARSALILRGSVAHKSC
Automotive security system for performing dynamic actions in response to a manipulation and/or intrusion detection in a vehicle, comprising: at least one secure electronic control unit, ECU,, - wherein software components running on the secure ECU are isolated using a virtualization technique, and - wherein the secure ECU comprises at least one security-critical software component, wherein the at least one security-critical software component is a software component related to one or more functions of the secure ECU that are relevant for a safety of a driver and/or other passengers in the vehicle; and a manipulation detection component operable to detect a software manipulation on the software components during a boot process of the secure ECU and/or during a runtime of the secure ECU, wherein upon detection of a software manipulation on at least one software component of the software components, the manipulation detection component is operable to actively de-activate at least the manipulated software component while the security-critical software component remains active. at least one secure electronic control unit, ECU,, - wherein software components running on the secure ECU are isolated using a virtualization technique, and - wherein the secure ECU comprises at least one security-critical software component, wherein the at least one security-critical software component is a software component related to one or more functions of the secure ECU that are relevant for a safety of a driver and/or other passengers in the vehicle; and - wherein software components running on the secure ECU are isolated using a virtualization technique, and - wherein the secure ECU comprises at least one security-critical software component, wherein the at least one security-critical software component is a software component related to one or more functions of the secure ECU that are relevant for a safety of a driver and/or other passengers in the vehicle; and a manipulation detection component operable to detect a software manipulation on the software components during a boot process of the secure ECU and/or during a runtime of the secure ECU, wherein upon detection of a software manipulation on at least one software component of the software components, the manipulation detection component is operable to actively de-activate at least the manipulated software component while the security-critical software component remains active.
A motion assistance apparatus comprising: a waist frame configured to support a waist of a user wearing the motion assistance apparatus; and a proximal support configured to simultaneously perform a rotation and a translation with respect to the waist frame, characterized in that the proximal support includes a head plate with a first guide slot having the shape of an arc extending downward and backwards when the user is in a standing state, and a second guide slot that extends towards a curved portion of the first guide slot, the second guide slot being on a side further to a rear side of the user than the first guide slot, and the waist frame includes a first projection and a second projection, the second projection spaced apart from the first projection by a projection distance, the first projection and the second projection configured to penetrate the first guide slot and the second guide slot, respectively. a waist frame configured to support a waist of a user wearing the motion assistance apparatus; and a proximal support configured to simultaneously perform a rotation and a translation with respect to the waist frame, characterized in that the proximal support includes a head plate with a first guide slot having the shape of an arc extending downward and backwards when the user is in a standing state, and a second guide slot that extends towards a curved portion of the first guide slot, the second guide slot being on a side further to a rear side of the user than the first guide slot, and the waist frame includes a first projection and a second projection, the second projection spaced apart from the first projection by a projection distance, the first projection and the second projection configured to penetrate the first guide slot and the second guide slot, respectively.
An external rotor electric machine comprising: an internal stator; and an external rotor coaxial to the internal stator; the external rotor including an inner surface facing the internal stator; the external rotor including permanent magnets arranged in a circumferential direction on the internal surface of the rotor, and magnetically susceptible protrusions (23, 32, 34, 36) respectively arranged between adjacent permanent magnets; the magnetically susceptible protrusions being so configured and sized as to position the magnets with a non equal angular spacing between consecutive adjacent magnets so as to reduce cogging torque and torque ripple, wherein the protrusions (23, 32, 34, 36) consist of individual ring segments including a central protrusion, two lateral protrusions (34, 36) and two permanent magnet receiving portions (38, 40), one lateral protrusion (34, 36) and one permanent magnet receiving portion (38, 40) located on each side of the central protrusion, wherein each permanent magnet receiving portion (38, 40) is located between the central protrusion and one of the lateral protrusions (34, 36), and rounded notches between the central and lateral protrusions (32, 34, 36) and the respective permanent magnet receiving portions (38, 40). an internal stator; and an external rotor coaxial to the internal stator; the external rotor including an inner surface facing the internal stator; the external rotor including permanent magnets arranged in a circumferential direction on the internal surface of the rotor, and magnetically susceptible protrusions (23, 32, 34, 36) respectively arranged between adjacent permanent magnets; the magnetically susceptible protrusions being so configured and sized as to position the magnets with a non equal angular spacing between consecutive adjacent magnets so as to reduce cogging torque and torque ripple, wherein the protrusions (23, 32, 34, 36) consist of individual ring segments including a central protrusion, two lateral protrusions (34, 36) and two permanent magnet receiving portions (38, 40), one lateral protrusion (34, 36) and one permanent magnet receiving portion (38, 40) located on each side of the central protrusion, wherein each permanent magnet receiving portion (38, 40) is located between the central protrusion and one of the lateral protrusions (34, 36), and rounded notches between the central and lateral protrusions (32, 34, 36) and the respective permanent magnet receiving portions (38, 40).
A method for managing data packets (IP PDU tx, PDCP PDU tx, RLC PDU tx, MAC PDU tx) transmitted by a first user equipment to be received by a second user equipment, wherein the first user equipment is arranged for communicating with the second user equipment in a direct mode by directly connecting to the second user equipment or in an infrastructure mode by connecting to the second user equipment through a radio transceiver station of a radio network, the first user equipment being configured for: generating data packets (IP PDU tx) at an Internet Protocol layer of the protocol stack to be transmitted; forwarding each data packet (IP PDU tx) to a lower protocol layer of the protocol stack in order to be sent to the second user equipment in direct mode or in infrastructure mode, characterized by comprising: providing at least one buffer protocol entity below the Internet Protocol layer, wherein the at least one buffer protocol entity is provided at a sublayer provided between the Internet Protocol layer and the Packet Data Convergence Protocol layer of the protocol stack, wherein the at least one buffer protocol entity is arranged for: storing a copy of each data packet (IP PDU tx) forwarded from the Internet Protocol layer to the lower protocol layer; removing the copy of a data packet (IP PDU tx) stored in the buffer protocol entity upon acknowledge of the receipt of the corresponding data packet at the second user equipment, and in case the first user equipment switches from communicating with the second user equipment in the direct mode to the infrastructure mode or, vice versa, from the infrastructure mode to the direct mode: forwarding the copy of each data packet (IP PDU tx) comprised in the buffer protocol entity to the lower protocol layer of the protocol stack in order to be sent to the second user equipment in infrastructure mode or in direct mode, respectively. generating data packets (IP PDU tx) at an Internet Protocol layer of the protocol stack to be transmitted; forwarding each data packet (IP PDU tx) to a lower protocol layer of the protocol stack in order to be sent to the second user equipment in direct mode or in infrastructure mode, storing a copy of each data packet (IP PDU tx) forwarded from the Internet Protocol layer to the lower protocol layer; removing the copy of a data packet (IP PDU tx) stored in the buffer protocol entity upon acknowledge of the receipt of the corresponding data packet at the second user equipment, and in case the first user equipment switches from communicating with the second user equipment in the direct mode to the infrastructure mode or, vice versa, from the infrastructure mode to the direct mode: forwarding the copy of each data packet (IP PDU tx) comprised in the buffer protocol entity to the lower protocol layer of the protocol stack in order to be sent to the second user equipment in infrastructure mode or in direct mode, respectively.
An article of footwear, comprising: an upper; a sole system having associated a first axis parallel with a lower surface thereof and extending in a longitudinal direction of the article of footwear; an arch wrap configured to be disposed adjacent to a midfoot of a foot, the arch wrap including a forward portion disposed adjacent to a toe portion of the sole system; the arch wrap further including a first extended portion and a second extended portion, each of the extended portions (151, 152) having associated a second axis extending through the length thereof and being angled with respect to the first axis, such that the extended portions (151, 152) extend at an angle with respect to the lower surface of the sole system from the forward portion along the second axis thereof between the toe portion and an entry hole of the upper, wherein the arch wrap is attached to an outer surface of the upper, characterized in that the forward portion includes a first lower protrusion and a second lower protrusion, wherein the first lower protrusion and the second lower protrusion extend through a portion of the toe portion of the sole system overlapping with the sole system. an upper; a sole system having associated a first axis parallel with a lower surface thereof and extending in a longitudinal direction of the article of footwear; an arch wrap configured to be disposed adjacent to a midfoot of a foot, the arch wrap including a forward portion disposed adjacent to a toe portion of the sole system; the arch wrap further including a first extended portion and a second extended portion, each of the extended portions (151, 152) having associated a second axis extending through the length thereof and being angled with respect to the first axis, such that the extended portions (151, 152) extend at an angle with respect to the lower surface of the sole system from the forward portion along the second axis thereof between the toe portion and an entry hole of the upper, wherein the arch wrap is attached to an outer surface of the upper, characterized in that the forward portion includes a first lower protrusion and a second lower protrusion, wherein the first lower protrusion and the second lower protrusion extend through a portion of the toe portion of the sole system overlapping with the sole system.
Drive train assembly for driving a working unit with fluctuating power consumption from a drive source, comprising a flywheel accumulator for mitigating load impacts and/or power consumption fluctuations, and a starting aid for easier starting up of the flywheel accumulator into a desired speed range, wherein the starting aid comprises a planetary transmission which comprises at least one planetary transmission stage, which is connected in terms of drive to the flywheel accumulator, characterized in that the planetary transmission comprises a fixed drive, which, bypassing the planetary transmission stage, leads from the planetary transmission input side to an output shaft, which leads from the planetary transmission to the working unit, wherein said flywheel accumulator is branched with respect to said fix drive via the planetary transmission stage, and is variable in speed with respect to the drive speed of the output shaft, which leads to the working unit, wherein the planetary transmission comprises a drive and/or brake actuator for braking and/or accelerating a planetary transmission element in order to adjust the step-up/step-down ratio of the at least one planetary transmission stage when starting up the flywheel accumulator into its desired speed range.
A pharmaceutical formulation in solid oral dosage form comprising: (a) N-(4-(4-amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (Compound I), or a pharmaceutically acceptable salt, solvate or hydrate thereof; (b) an organic acid; and (c) a surfactant, wherein the surfactant is a poloxamer. (a) N-(4-(4-amino-7-(1-isobutyrylpiperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (Compound I), or a pharmaceutically acceptable salt, solvate or hydrate thereof; (b) an organic acid; and (c) a surfactant, wherein the surfactant is a poloxamer.
Compound 1, or pharmaceutically acceptable salt thereof: for use in the treatment of lung cancer, wherein the treatment comprises administering Compound 1 or pharmaceutically acceptable salt thereof with both etoposide and cisplatin.