A compound of Formula: or a tautomer thereof, or pharmaceutically acceptable salt of each thereof, wherein R 3 is C 6 -C 10 aryl or a 5-10 membered heteroaryl, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S, wherein the aryl or heteroaryl is optionally substituted with 1-4 C 1 -C 6 alkyl; L 1 is a bond; L 2 is C=O or SO 2; ring B is an optionally substituted 4-10 membered heterocycle containing up to 5 ring heteroatoms, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S; Z is O; wherein the -CH 2 Z- group is α or β substituted relative to the -L 1 L 2 R 3; wherein, unless stated otherwise, "optionally substituted" refers to a substituted or unsubstituted group, wherein the group may be substituted with one or more substituents selected from the group consisting of oxo, halo, -CN, NO 2, -N 2 +, -CO 2 R 100, -OR 100, -SR 100, -SOR 100, - SO 2 R 100, -NR 101 R 102, -CONR 101 R 102, -SO 2 NR 101 R 102, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -CR 100 =C(R 100) 2, -CCR 100, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl and C 2 -C 12 heteroaryl, wherein each R 100 independently is hydrogen, C 1 -C 8 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl; wherein each alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 halo, 1-3 C 1 -C 6 alkyl, 1-3 C 1 -C 6 haloalkyl, or 1-3 C 1 -C 6 alkoxy; and R 101 and R 102 independently is hydrogen, C 1 -C 8 alkyl optionally substituted with - CO 2 H or an ester thereof, C 1 -C 6 alkoxy, oxo, -CR 103 =C(R 103) 2, -CCR, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl, wherein each R 103 independently is hydrogen, C 1 -C 8 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl; wherein each cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 alkyl groups or 1-3 halo groups, or R 101 and R 102 together with the nitrogen atom they are attached to form a 5-7 membered heterocycle. R 3 is C 6 -C 10 aryl or a 5-10 membered heteroaryl, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S, wherein the aryl or heteroaryl is optionally substituted with 1-4 C 1 -C 6 alkyl; L 1 is a bond; L 2 is C=O or SO 2; ring B is an optionally substituted 4-10 membered heterocycle containing up to 5 ring heteroatoms, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S; Z is O; wherein the -CH 2 Z- group is α or β substituted relative to the -L 1 L 2 R 3; wherein, unless stated otherwise, "optionally substituted" refers to a substituted or unsubstituted group, wherein the group may be substituted with one or more substituents selected from the group consisting of oxo, halo, -CN, NO 2, -N 2 +, -CO 2 R 100, -OR 100, -SR 100, -SOR 100, - SO 2 R 100, -NR 101 R 102, -CONR 101 R 102, -SO 2 NR 101 R 102, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -CR 100 =C(R 100) 2, -CCR 100, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl and C 2 -C 12 heteroaryl, wherein each R 100 independently is hydrogen, C 1 -C 8 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl; wherein each alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 halo, 1-3 C 1 -C 6 alkyl, 1-3 C 1 -C 6 haloalkyl, or 1-3 C 1 -C 6 alkoxy; and R 101 and R 102 independently is hydrogen, C 1 -C 8 alkyl optionally substituted with - CO 2 H or an ester thereof, C 1 -C 6 alkoxy, oxo, -CR 103 =C(R 103) 2, -CCR, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl, wherein each R 103 independently is hydrogen, C 1 -C 8 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 10 heterocyclyl, C 6 -C 12 aryl, or C 2 -C 12 heteroaryl; wherein each cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 alkyl groups or 1-3 halo groups, or R 101 and R 102 together with the nitrogen atom they are attached to form a 5-7 membered heterocycle.