A process for isolating and simultaneously amplifying at least a first and a second target nucleic acid that may be present in one or more fluid samples, said process comprising the automated steps of: a. adding a scrambled internal control nucleic acid selected from the group of SEQ ID NOs 45 to 49 to each of said fluid samples, wherein the sequence of said internal control nucleic acid is identical for said at least first and second target nucleic acids b. combining together a solid support material and said one or more fluid samples in one or more vessels for a period of time and under conditions sufficient to permit nucleic acids comprising the target nucleic acids and the internal control nucleic acid to be immobilized on the solid support material c. isolating the solid support material from the other material present in the fluid samples in a separation station d. purifying the nucleic acids in said separation station and washing the solid support material one or more times with a wash buffer e. contacting the purified target nucleic acids and the purified internal control nucleic acid with amplification reagents comprising a polymerase with reverse transcriptase activity and at least one distinct set of primers for each of said target nucleic acids and for said internal control nucleic acid in at least two reaction vessels, wherein at least a first reaction vessel comprises primers for at least said first target nucleic acid and at least a second reaction vessel comprises primers for at least said second target nucleic acid and wherein the primers for the second target nucleic acid are absent from the first reaction vessel e2. incubating in said reaction vessels said purified nucleic acids with said amplification reagents for a period of time and under conditions suitable for transcription of RNA by said polymerase with reverse transcriptase activity to occur, wherein the period of time is up to 10 minutes f. incubating in said reaction vessels said purified target nucleic acids and said purified internal control nucleic acid with said amplification reagents for a period of time and under conditions sufficient for an amplification reaction indicative of the presence or absence of said target nucleic acids to occur g. detecting and measuring signals generated by the amplification products of said target nucleic acids and being proportional to the concentration of said target nucleic acids, and detecting and measuring a signal generated by said internal control nucleic acid, wherein the conditions for amplification and detection in steps e. to g. are identical for said at least first and second purified target nucleic acids and said internal control nucleic acid, and wherein the first and/or the second target nucleic acid is a bacterial nucleic acid, and wherein the at least two target nucleic acids comprise RNA and DNA. a. adding a scrambled internal control nucleic acid selected from the group of SEQ ID NOs 45 to 49 to each of said fluid samples, wherein the sequence of said internal control nucleic acid is identical for said at least first and second target nucleic acids b. combining together a solid support material and said one or more fluid samples in one or more vessels for a period of time and under conditions sufficient to permit nucleic acids comprising the target nucleic acids and the internal control nucleic acid to be immobilized on the solid support material c. isolating the solid support material from the other material present in the fluid samples in a separation station d. purifying the nucleic acids in said separation station and washing the solid support material one or more times with a wash buffer e. contacting the purified target nucleic acids and the purified internal control nucleic acid with amplification reagents comprising a polymerase with reverse transcriptase activity and at least one distinct set of primers for each of said target nucleic acids and for said internal control nucleic acid in at least two reaction vessels, wherein at least a first reaction vessel comprises primers for at least said first target nucleic acid and at least a second reaction vessel comprises primers for at least said second target nucleic acid and wherein the primers for the second target nucleic acid are absent from the first reaction vessel e2. incubating in said reaction vessels said purified nucleic acids with said amplification reagents for a period of time and under conditions suitable for transcription of RNA by said polymerase with reverse transcriptase activity to occur, wherein the period of time is up to 10 minutes f. incubating in said reaction vessels said purified target nucleic acids and said purified internal control nucleic acid with said amplification reagents for a period of time and under conditions sufficient for an amplification reaction indicative of the presence or absence of said target nucleic acids to occur g. detecting and measuring signals generated by the amplification products of said target nucleic acids and being proportional to the concentration of said target nucleic acids, and detecting and measuring a signal generated by said internal control nucleic acid,