A compound of formula: or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein D 1 is an isoxazole or pyrazole, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, halogen, amide, CF 3, CN, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), -COOH, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), - SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with one or more hydrogen, F, Cl, Br, -OH, -NH 2, -NHMe, -OMe, -SMe, oxo, and/or thio-oxo; X is present and is selected from - -, -O-, -NHCR x R y -, -NHSO 2 -, -CR x R y NH-; and R x and R y are each independently selected from hydrogen, alkyl(C 1-5), halogen, -OH, -CF 3, deuterium, amino, alkoxy(C 1-5), or two substituents selected from R x, R y, and R 1 may be connected in a 5- or 6-membered ring to form a bicyclic carbocycle or bicyclic heterocycle; Z 1 is -NRa; R a is selected from hydrogen, deuterium, and alkyl (C 1-3); and R 1 and R 2 are independently selected from hydrogen, deuterium, alkyl, -OH, -NH 2, -thioalkyl, and alkoxy; R 3 is an isoxazole, pyrazole, pyridyl, thiazole, isothiazole, pyrimidine, phenyl, cyclohexene, benzo[d]oxazolyl, napthyl, or quinolyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, - CF 3, CN, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), - SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with one or more hydrogen, F, Cl, Br, -OH, -NH 2, -NHMe, -OMe, -SMe, oxo, and/or thio-oxo. D 1 is an isoxazole or pyrazole, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, halogen, amide, CF 3, CN, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), -COOH, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), - SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with one or more hydrogen, F, Cl, Br, -OH, -NH 2, -NHMe, -OMe, -SMe, oxo, and/or thio-oxo; X is present and is selected from - -, -O-, -NHCR x R y -, -NHSO 2 -, -CR x R y NH-; and R x and R y are each independently selected from hydrogen, alkyl(C 1-5), halogen, -OH, -CF 3, deuterium, amino, alkoxy(C 1-5), or two substituents selected from R x, R y, and R 1 may be connected in a 5- or 6-membered ring to form a bicyclic carbocycle or bicyclic heterocycle; Z 1 is -NRa; R a is selected from hydrogen, deuterium, and alkyl (C 1-3); and R 1 and R 2 are independently selected from hydrogen, deuterium, alkyl, -OH, -NH 2, -thioalkyl, and alkoxy; R 3 is an isoxazole, pyrazole, pyridyl, thiazole, isothiazole, pyrimidine, phenyl, cyclohexene, benzo[d]oxazolyl, napthyl, or quinolyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C 1 -C 4), -OH, alkoxy(C 1 -C 4), amino, halogen, amide, - CF 3, CN, -N 3, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), -SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), carboxyl, and/or ester, wherein said alkyl(C 1 -C 4), alkoxy(C 1 -C 4), amino, amide, ketone (C 1 -C 4), -S Alkyl(C 1 -C 4), - SO 2 alkyl(C 1 -C 4), -thioalkyl(C 1 -C 4), and ester may be optionally substituted with one or more hydrogen, F, Cl, Br, -OH, -NH 2, -NHMe, -OMe, -SMe, oxo, and/or thio-oxo.