A compound of formula; wherein - the moiety is selected from wherein the wavy line () indicates the point of attachment to the carbonyl of the main formula; wherein said moiety is substituted with one or two Z 1; - cycle B is selected from and wherein the wavy line () indicates the point of attachment to the carbon atom of the main formula, and wherein the depicted cycles are substituted with one, two, or three Z 1a; - R 1 is selected from C 3-7 cycloalkyl, aryl, and heterocycle; and wherein said C 3-7 cycloalkyl, aryl, and heterocycle, are substituted with one, two, or three Z 1b; - R 2 is hydrogen; - each Z 1, Z 1a, and Z 1b, is independently selected from the group consisting of halogen, hydroxyl, -OZ 2, -O-C(=O)Z 3, =O, -S(=O) 2 Z 3, -S(=O) 2 NZ 4 Z 5, trifluoromethyl, trifluoromethoxy, -NZ 4 Z 5, - NZ 4 C(=O)Z 2, -NZ 4 C(=O)-OZ 2, cyano, -C(=O)Z 3, -C(=O)OZ 2, -C(=O)NZ 4 Z 5, C 1-6 alkyl, heteroC 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl; and wherein said C 1-6 alkyl, heteroC 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl, are optionally substituted with one, two, or three substituents selected from hydroxyl, =O, halogen, trifluoromethyl, -OCF 3, -O-C Me, cyano, nitro, -C OH, -C OC 1-6 alkyl, - NH 2, -NHCH 3, -N(CH 3) 2, -NH-C(=O)O-C 1-4 alkyl, -S 2 C 1-4 alkyl, and -O-C 1-6 alkyl; - each Z 2 is independently selected from C 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl; wherein said C 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl, are optionally substituted with one, two, or three substituents selected from hydroxyl, =O, halogen, trifluoromethyl, difluoromethyl, -O-C 1-6 alkyl, -OCF 3, -S(=O) 2 C 1-4 alkyl, cyano, -C(=O)OH, - C(=O)O-C 1-4 alkyl, -NH 2, -N(CH 3) 2, pyrrolidinyl, piperidinyl, and piperazinyl; - each Z 3 is independently selected from hydroxyl, C 1-6 alkyl, aryl, and heterocycle; wherein said C 1-6 alkyl, aryl, and heterocycle are optionally substituted with one, two, or three substituents selected from C 1-6 alkyl and -N(CH 3) 2; - each Z 4 and Z 5 is independently selected from hydrogen, C 1-6 alkyl, aryl, C 3-7 cycloalkyl, and heterocycle; and stereo-isomers or tautomers, solvates, salts in particular pharmaceutically acceptable salts thereof; wherein the term "heterocycle" means a saturated, unsaturated, or aromatic ring system of 3 to 18 atoms including at least one N, O, S or P. - the moiety is selected from wherein the wavy line () indicates the point of attachment to the carbonyl of the main formula; wherein said moiety is substituted with one or two Z 1; - cycle B is selected from and - R 1 is selected from C 3-7 cycloalkyl, aryl, and heterocycle; and wherein said C 3-7 cycloalkyl, aryl, and heterocycle, are substituted with one, two, or three Z 1b; - R 2 is hydrogen; - each Z 1, Z 1a, and Z 1b, is independently selected from the group consisting of halogen, hydroxyl, -OZ 2, -O-C(=O)Z 3, =O, -S(=O) 2 Z 3, -S(=O) 2 NZ 4 Z 5, trifluoromethyl, trifluoromethoxy, -NZ 4 Z 5, - NZ 4 C(=O)Z 2, -NZ 4 C(=O)-OZ 2, cyano, -C(=O)Z 3, -C(=O)OZ 2, -C(=O)NZ 4 Z 5, C 1-6 alkyl, heteroC 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl; and wherein said C 1-6 alkyl, heteroC 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl, are optionally substituted with one, two, or three substituents selected from hydroxyl, =O, halogen, trifluoromethyl, -OCF 3, -O-C Me, cyano, nitro, -C OH, -C OC 1-6 alkyl, - NH 2, -NHCH 3, -N(CH 3) 2, -NH-C(=O)O-C 1-4 alkyl, -S 2 C 1-4 alkyl, and -O-C 1-6 alkyl; - each Z 2 is independently selected from C 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl; wherein said C 1-6 alkyl, aryl, heterocycle, and heterocycle-C 1-6 alkyl, are optionally substituted with one, two, or three substituents selected from hydroxyl, =O, halogen, trifluoromethyl, difluoromethyl, -O-C 1-6 alkyl, -OCF 3, -S(=O) 2 C 1-4 alkyl, cyano, -C(=O)OH, - C(=O)O-C 1-4 alkyl, -NH 2, -N(CH 3) 2, pyrrolidinyl, piperidinyl, and piperazinyl; - each Z 3 is independently selected from hydroxyl, C 1-6 alkyl, aryl, and heterocycle; wherein said C 1-6 alkyl, aryl, and heterocycle are optionally substituted with one, two, or three substituents selected from C 1-6 alkyl and -N(CH 3) 2; - each Z 4 and Z 5 is independently selected from hydrogen, C 1-6 alkyl, aryl, C 3-7 cycloalkyl, and heterocycle;