A polynucleotide encoding: (i) a humanized monoclonal antibody that binds to STEAP-1, wherein the antibody comprises a heavy chain comprising: an HVR-H1 comprising the amino acid sequence of SEQ ID NO:14; an HVR-H2 comprising the amino acid sequence of SEQ ID NO:15; an HVR-H3 comprising the amino acid sequence of SEQ ID NO:16; and an HC-FR1 comprising the amino acid sequence of SEQ ID NO:25; and a light chain comprising: an HVR-L1 comprising the amino acid sequence of SEQ ID NO:11; an HVR-L2 comprising the amino acid sequence of SEQ ID NO:12; and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:13, wherein optionally the light chain comprises: a light chain region comprising the amino acid sequence of SEQ ID NO:90; a light chain region comprising the amino acid sequence of SEQ ID NO:91; a light chain region comprising the amino acid sequence of SEQ ID NO:92; a light chain region comprising the amino acid sequence of SEQ ID NO:93; a light chain region comprising the amino acid sequence of SEQ ID NO:94; a light chain region comprising the amino acid sequence of SEQ ID NO:95; a light chain region comprising the amino acid sequence of SEQ ID NO:96; a light chain region comprising the amino acid sequence of SEQ ID NO:97; a light chain region comprising the amino acid sequence of SEQ ID NO:98; a light chain region comprising the amino acid sequence of SEQ ID NO:99; a light chain region comprising the amino acid sequence of SEQ ID NO:100; or a light chain region comprising the amino acid sequence of SEQ ID NO:101. (i) a humanized monoclonal antibody that binds to STEAP-1, wherein the antibody comprises a heavy chain comprising: an HVR-H1 comprising the amino acid sequence of SEQ ID NO:14; an HVR-H2 comprising the amino acid sequence of SEQ ID NO:15; an HVR-H3 comprising the amino acid sequence of SEQ ID NO:16; and an HC-FR1 comprising the amino acid sequence of SEQ ID NO:25; and a light chain comprising: an HVR-L1 comprising the amino acid sequence of SEQ ID NO:11; an HVR-L2 comprising the amino acid sequence of SEQ ID NO:12; and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:13, wherein optionally the light chain comprises: a light chain region comprising the amino acid sequence of SEQ ID NO:90; a light chain region comprising the amino acid sequence of SEQ ID NO:91; a light chain region comprising the amino acid sequence of SEQ ID NO:92; a light chain region comprising the amino acid sequence of SEQ ID NO:93; a light chain region comprising the amino acid sequence of SEQ ID NO:94; a light chain region comprising the amino acid sequence of SEQ ID NO:95; a light chain region comprising the amino acid sequence of SEQ ID NO:96; a light chain region comprising the amino acid sequence of SEQ ID NO:97; a light chain region comprising the amino acid sequence of SEQ ID NO:98; a light chain region comprising the amino acid sequence of SEQ ID NO:99; a light chain region comprising the amino acid sequence of SEQ ID NO:100; or a light chain region comprising the amino acid sequence of SEQ ID NO:101. an HVR-H1 comprising the amino acid sequence of SEQ ID NO:14; an HVR-H2 comprising the amino acid sequence of SEQ ID NO:15; an HVR-H3 comprising the amino acid sequence of SEQ ID NO:16; and an HC-FR1 comprising the amino acid sequence of SEQ ID NO:25; and a light chain comprising: an HVR-L1 comprising the amino acid sequence of SEQ ID NO:11; an HVR-L2 comprising the amino acid sequence of SEQ ID NO:12; and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:13, an HVR-L1 comprising the amino acid sequence of SEQ ID NO:11; an HVR-L2 comprising the amino acid sequence of SEQ ID NO:12; and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:13, a light chain region comprising the amino acid sequence of SEQ ID NO:90; a light chain region comprising the amino acid sequence of SEQ ID NO:91; a light chain region comprising the amino acid sequence of SEQ ID NO:92; a light chain region comprising the amino acid sequence of SEQ ID NO:93; a light chain region comprising the amino acid sequence of SEQ ID NO:94; a light chain region comprising the amino acid sequence of SEQ ID NO:95; a light chain region comprising the amino acid sequence of SEQ ID NO:96; a light chain region comprising the amino acid sequence of SEQ ID NO:97; a light chain region comprising the amino acid sequence of SEQ ID NO:98; a light chain region comprising the amino acid sequence of SEQ ID NO:99; a light chain region comprising the amino acid sequence of SEQ ID NO:100; or a light chain region comprising the amino acid sequence of SEQ ID NO:101.