mhurhangee/ep-ind-claims huggingface dataset:
A recombinant anti-oxMIF antibody or an antigen binding fragment thereof having reduced aggregation potential and reduced hydrophobicity, comprising the following variable domains: a light chain variable domain comprising SEQ ID NO:9 with 1, 2, 3, 4, or 5 amino acid substitutions selected from M30L, F49Y, A51G, P80S and W93F, or a light chain variable domain comprising SEQ ID NO:9 with 1, 2, 3, 4, or 5 amino acid substitutions selected from M30L, F49Y, A51G, P80S and W93F, and with 1, 2, 3, 4, or 5 further amino acid substitutions, with the proviso that the tyrosine at position 36 is preserved, and one of a heavy chain variable domain comprising SEQ ID NO:6; or a heavy chain variable domain comprising SEQ ID NO:6 with 1 or 2 amino acid substitutions selected from L5Q and W97Y, or a heavy chain variable domain comprising SEQ ID NO:6 with 1 or 2 amino acid substitutions selected from L5Q and W97Y, and with 1, 2, 3, 4 or 5 further amino acid substitutions, wherein amino acid positions are numbered according to Kabat, and wherein aggregation potential and hydrophobicity are reduced compared to an antibody or an antigen binding fragment thereof comprising SEQ ID NO:6 and SEQ ID NO:9 lacking the amino acid substitutions. a light chain variable domain comprising SEQ ID NO:9 with 1, 2, 3, 4, or 5 amino acid substitutions selected from M30L, F49Y, A51G, P80S and W93F, or a light chain variable domain comprising SEQ ID NO:9 with 1, 2, 3, 4, or 5 amino acid substitutions selected from M30L, F49Y, A51G, P80S and W93F, and with 1, 2, 3, 4, or 5 further amino acid substitutions, with the proviso that the tyrosine at position 36 is preserved, and one of a heavy chain variable domain comprising SEQ ID NO:6; or a heavy chain variable domain comprising SEQ ID NO:6 with 1 or 2 amino acid substitutions selected from L5Q and W97Y, or a heavy chain variable domain comprising SEQ ID NO:6 with 1 or 2 amino acid substitutions selected from L5Q and W97Y, and with 1, 2, 3, 4 or 5 further amino acid substitutions, wherein amino acid positions are numbered according to Kabat, and wherein aggregation potential and hydrophobicity are reduced compared to an antibody or an antigen binding fragment thereof comprising SEQ ID NO:6 and SEQ ID NO:9 lacking the amino acid substitutions.
A method for establishing a communication session having more than one media type, the method performed at a second device, comprising: receiving, by the second device, from a network apparatus, a communication session invitation associated with establishing a communication session between a first device and the second device via the network apparatus, the communication session invitation offering more than one media type for the communication session; characterised by sending a response message to the network apparatus responsive to communication session invitation, the response message including one or more addresses of devices (24-2, 24-N) and corresponding media types for each of said devices (24-2, 24-N), including at least an address, to be used for the communication session, for a third device and identifying at least one corresponding media type to be used between the first device and the third device, wherein the response message is a SIP 300 Multiple Choices response message. receiving, by the second device, from a network apparatus, a communication session invitation associated with establishing a communication session between a first device and the second device via the network apparatus, the communication session invitation offering more than one media type for the communication session; characterised by sending a response message to the network apparatus responsive to communication session invitation, the response message including one or more addresses of devices (24-2, 24-N) and corresponding media types for each of said devices (24-2, 24-N), including at least an address, to be used for the communication session, for a third device and identifying at least one corresponding media type to be used between the first device and the third device, wherein the response message is a SIP 300 Multiple Choices response message.
Hip joint endoprosthesis system with a medical instrumentarium for implanting a hip joint endoprosthesis comprising at least one medical instrument for inserting a joint insert into a joint socket of the hip joint endoprosthesis, wherein the instrument defines a longitudinal axis and comprises a holding element for temporarily coupling to the joint insert and a centering body for centering the joint insert relative to the holding element, wherein the holding element has at least one retaining member which has a retaining face, characterized in that the retaining face is inclined with respect to the longitudinal axis, in that the retaining face is configured in the form of an annular face facing in the direction toward the longitudinal axis, and in that the retaining face is configured in the form of an inner conical face tapering in distal direction.
A washing machine comprising a drawer, comprising a housing accommodating the drawer, wherein the drawer comprises a panel and a tray connected to the panel, a linearly movable lock body is provided on the tray, the lock body comprises a tongue portion, the housing comprises a lock slot capable of accommodating the tongue portion to restrict movement of the drawer, and a first spring acts on the lock body and applies a force to the lock body in a direction that causes the tongue portion to be inserted into the lock slot, the lock body further comprises a first slope inclined relative to a movement direction of the lock body, the panel comprises a fixed portion and a moving portion movable relative to the fixed portion, the moving portion comprises a push rod, a head portion of the push rod faces the first slope when the lock body is in a locked position, that is, when the tongue portion is located in the lock slot, the tongue portion has a second slope facing a push-in direction of the drawer, and wherein the drawer moves back and forth along a first direction, the lock body moves along a second direction, and the first direction is approximately perpendicular to the second direction characterized in that the head portion of the push rod is located in a recess at the bottom of the first slope when the lock body is in an unlocked position, that is, when the tongue portion is detached from the lock slot and the first spring releases a thrust to push the lock body to move to a pre-mounting position.
A method for the installation and repair of insulated piping, wherein the insulated piping comprises an outer pipe (1, 1.1, 1.2) made of a weldable polymer material that encases an inner pipe (2, 2.1, 2.2) embedded in an insulating layer, and wherein the inner pipe (2, 2.1, 2.2) has been substantially exposed over a section between the ends (1 a, 1 b) of the two outer pipes; wherein the method comprises the fact that a sleeve coupling, made of a weldable polymer material incorporating a slit that runs lengthwise along the piping, and whose length exceeds the distance between the outer pipes' ends (1 a, 1 b), is placed over the exposed section of the inner pipe (2, 2.1, 2.2) and overlaps the ends (1 a, 1 b) of the outer pipes; the fact that the sleeve coupling is welded to the outer pipe (1, 1.1, 1.2), the ends (1 a, 1 b) of the outer pipes, by placing an electrically conductive band that is pervious to molten plastic between the outer pipe (1, 1.1, 1.2) and the sleeve coupling, ensuring that the free ends of the band project upward through the slit; and that electric current is connected to the band, to the ends brought up through the slit, for a determined period of time, to heat the band and the surrounding polymer material so that they fuse together around the band in order to form a weld joint; and characterized in that two series-connected power converters that are connected to two different power sources of different phase are employed and the output voltage is summed via the synchronous operation of two quasi-resonant converters in order to produce the electric current that is to be connected to the band.
A binding machine comprising: a feeding unit capable of feeding a wire and winding the wire around a to-be-bound object during a binding operation; a function unit movable between a first position located on a feeding locus of the wire and a second position deviating from a position on the feeding locus of the wire, and a control unit configured to move the function unit between the first position and the second position, wherein the function unit is a regulation part (4A, 4B) configured to guide the wire in contact with the wire, wherein the control unit is configured to locate the regulation part in the first position when the wire is fed and configured to locate the regulation part in the second position when the wire is wound around the to-be-bound object, wherein the control unit is configured to locate and stop the regulation part in the second position in a predetermined state, and characterized in that the predetermined state is after the binding operation is over or a case where poor feeding of the wire occurs. a feeding unit capable of feeding a wire and winding the wire around a to-be-bound object during a binding operation; a function unit movable between a first position located on a feeding locus of the wire and a second position deviating from a position on the feeding locus of the wire, and a control unit configured to move the function unit between the first position and the second position, wherein the function unit is a regulation part (4A, 4B) configured to guide the wire in contact with the wire, wherein the control unit is configured to locate the regulation part in the first position when the wire is fed and configured to locate the regulation part in the second position when the wire is wound around the to-be-bound object, wherein the control unit is configured to locate and stop the regulation part in the second position in a predetermined state, and characterized in that the predetermined state is after the binding operation is over or a case where poor feeding of the wire occurs.
A mounting system for selectively positioning a hinged seat (22, 118, 150) having hinge means (30, 122, 160) to rotatably support said seat (22, 118, 150) relative to an apertured toilet bowl flange (20, 110) comprising: post receptacle means (38, 39, 95, 114, 132) securable in each of a plurality of apertures in said bowl flange (20, 110); elongate post means (36, 37, 102, 112, 138) for extending downwardly from said hinge means (30, 122, 160) and extending through each of said receptacle means (38, 39, 95, 114, 132), said post means (36, 37, 102, 112, 138) being longitudinally movable in said receptacle means (38, 39, 95, 114, 132); and interference means between said receptacle means (38, 39, 95, 114, 132) and said post means (36, 37, 102, 112, 138) to control longitudinal motion of said post means (36, 37, 102, 112, 138) relative to said receptacle means (38, 39, 95, 114, 132), whereby said post means (36, 37, 102, 112, 138) can rest on said receptacle means (38, 39, 95, 114, 132) and can be raised so that said interference means reacts to releasably support said post means (36, 37, 102, 112, 138) and provide clearance above said receptacle means (38, 39, 95, 114, 132) for seat and toilet bowl cleaning and maintenance, wherein the interference means is a flared end portion of said post means (36, 37, 102, 112, 138). post receptacle means (38, 39, 95, 114, 132) securable in each of a plurality of apertures in said bowl flange (20, 110); elongate post means (36, 37, 102, 112, 138) for extending downwardly from said hinge means (30, 122, 160) and extending through each of said receptacle means (38, 39, 95, 114, 132), said post means (36, 37, 102, 112, 138) being longitudinally movable in said receptacle means (38, 39, 95, 114, 132); and interference means between said receptacle means (38, 39, 95, 114, 132) and said post means (36, 37, 102, 112, 138) to control longitudinal motion of said post means (36, 37, 102, 112, 138) relative to said receptacle means (38, 39, 95, 114, 132), whereby said post means (36, 37, 102, 112, 138) can rest on said receptacle means (38, 39, 95, 114, 132) and can be raised so that said interference means reacts to releasably support said post means (36, 37, 102, 112, 138) and provide clearance above said receptacle means (38, 39, 95, 114, 132) for seat and toilet bowl cleaning and maintenance,
Composite material comprising a metal matrix in aluminium, copper, aluminium alloy or copper alloy, and tin oxide functionalized carbon nanotubes dispersed in said metal matrix.
A stabilized formulation for sustained release of a vitamin D compound, the formulation comprising a mixture of: one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3; and a stabilizing agent comprising a material selected from the group consisting of: cellulose compounds, poloxamers, poly(ethylene oxide) polymers, povidones, fumed silicas, and combinations thereof, wherein the stabilizing agent is present in an amount of at least about 5% of the formulation, based on the total weight of the formulation excluding any additional coatings or shells (wt%), which is effective to maintain a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25°C and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions. one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3; and a stabilizing agent comprising a material selected from the group consisting of: cellulose compounds, poloxamers, poly(ethylene oxide) polymers, povidones, fumed silicas, and combinations thereof, wherein the stabilizing agent is present in an amount of at least about 5% of the formulation, based on the total weight of the formulation excluding any additional coatings or shells (wt%), which is effective to maintain a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25°C and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions.
Gap seal device, comprising a housing having a fluid-filled guiding chamber, a multi-part piston which can be moved translationally and/or rotationally in the guiding chamber, wherein the piston separates a high-pressure region from a low-pressure region of the guiding chamber, the piston forming an annular gap having a nominal gap width (S 0) with an inner wall delimiting the guiding chamber, characterized in that the piston comprises a stepped rod, a sleeve which is slipped over a stepped-down region of the rod and which has a blind hole, and a coupling, wherein at least one stiffness change (43, 56) is provided in the stepped-down region of the rod or a tube portion of the sleeve, wherein a gap width (Sv) of the annular gap which is reduced compared to the nominal gap width (S 0) can be set in a region radial to the stiffness change (43, 56) by means of stress-induced expansion of an outer diameter of the tube portion of the sleeve as a function of the set stressing force. a housing having a fluid-filled guiding chamber, a multi-part piston which can be moved translationally and/or rotationally in the guiding chamber, wherein the piston separates a high-pressure region from a low-pressure region of the guiding chamber, the piston forming an annular gap having a nominal gap width (S 0) with an inner wall delimiting the guiding chamber, characterized in that the piston comprises a stepped rod, a sleeve which is slipped over a stepped-down region of the rod and which has a blind hole, and a coupling, wherein at least one stiffness change (43, 56) is provided in the stepped-down region of the rod or a tube portion of the sleeve, wherein a gap width (Sv) of the annular gap which is reduced compared to the nominal gap width (S 0) can be set in a region radial to the stiffness change (43, 56) by means of stress-induced expansion of an outer diameter of the tube portion of the sleeve as a function of the set stressing force.
A closure device for connecting two assemblies to one another, comprising - a first closure part to be arranged on one of the assemblies and comprising a locking piece (41A, 41B) with a first locking section and a first magnetic element (43A, 43B), and - a second closure part to be fastened to the other of the assemblies and having a locking receptacle (51A, 51B) with a second locking section and a second magnetic element (43A, 43B), wherein the first closure part and the second closure part are attachable to one another in a closing direction and are connected to one another in a closed position by positive locking counter to the closing direction, by the locking piece (41A, 41B) of the first closure part being received in the locking receptacle (51A, 51B) of the second closure part and the first locking section of the locking piece (41A, 41B) being in a positively locked engagement with the second locking section of the locking receptacle (51A, 51B), wherein the first magnetic element (43A, 43B) and the second magnetic element (53A, 53B) are configured to assist magnetically the attachment of the first closure part and the second closure part to one another, characterized by an arresting mechanism arranged on the second closure part and having an arresting element (524, 527) and an actuating mechanism operatively connected to the arresting element (524, 527), wherein the arresting element (524, 527) can be brought into operative connection with the locking piece (41A, 41B) in the closed position, in order to lock the positively locked engagement between the first locking section and the second locking section, wherein the actuating mechanism may be actuated in order to adjust the arresting element (524, 527) relative to the locking receptacle (51A, 51B) so that the first locking section and the second locking section are releasable from one another. - a first closure part to be arranged on one of the assemblies and comprising a locking piece (41A, 41B) with a first locking section and a first magnetic element (43A, 43B), and - a second closure part to be fastened to the other of the assemblies and having a locking receptacle (51A, 51B) with a second locking section and a second magnetic element (43A, 43B), wherein the first closure part and the second closure part are attachable to one another in a closing direction and are connected to one another in a closed position by positive locking counter to the closing direction, by the locking piece (41A, 41B) of the first closure part being received in the locking receptacle (51A, 51B) of the second closure part and the first locking section of the locking piece (41A, 41B) being in a positively locked engagement with the second locking section of the locking receptacle (51A, 51B), wherein the first magnetic element (43A, 43B) and the second magnetic element (53A, 53B) are configured to assist magnetically the attachment of the first closure part and the second closure part to one another,
Pneumatic braking system for a railway vehicle, including first and second braking actuator means associated with the wheels of a respective axle (A1, A2) or a respective bogie (B1, B2) of the vehicle and to which there are connected a first electro-pneumatic control assembly and a second electro-pneumatic control assembly (1, 2) respectively, which first and second electro-pneumatic control assemblies (1, 2) are independent of each other and comprise each a charging solenoid valve and a discharging solenoid valve adapted to cause an increase and a reduction, respectively, of a pneumatic pressure supplied to the corresponding first or second braking actuator means, and a control unit arranged to control said first and second electro-pneumatic control assemblies (1, 2) as a function of a target braking pressure (P t), such that said first and second electro-pneumatic control assemblies (1, 2) cause the application of respective pressures (P1, P2) to the corresponding first or second braking actuator means; said control unit being arranged to control said first and second electro-pneumatic control assemblies (1, 2) so that respective braking pressure values (P1, P2), the sum of which substantially equals the value of the target braking pressure (P t), are applied to the first and second braking actuator means; the system being characterized in that the control unit is arranged to control, at least for a predetermined time interval, said first and second electro-pneumatic control assemblies (1, 2) in an alternate manner, so as to cause, in subsequent time instants separated by a predetermined interval, alternately a variation of the pressure value applied to the first braking actuator means and the value of the pressure applied to the second braking actuator means.
A partition skirt device for a cyclone separation unit of a cleaning apparatus, the partition skirt device having an annular structure, wherein the partition skirt device comprises: an annular inner ring; and an annular skirt body comprising: a root connected to the inner ring; an edge part arranged at an end of the skirt body away from the inner ring, a diameter of the edge part being larger than a diameter of the root; and a plurality of collapsing parts arranged at intervals between the root and the edge part along a circumferential direction of the skirt body, and the collapsing part being configured as a long strip structure extending along a radial direction of the skirt body, characterized in that along a thickness direction of the skirt body, the collapsing part protrudes relative to the skirt body on a first side surface of the skirt body, and is recessed relative to the skirt body on a second side surface of the skirt body and in that on the first side surface of the skirt body, a size of a portion of the collapsing part protruding from the skirt body gradually decreases from the root to the edge part. an annular inner ring; and an annular skirt body comprising: a root connected to the inner ring; an edge part arranged at an end of the skirt body away from the inner ring, a diameter of the edge part being larger than a diameter of the root; and a plurality of collapsing parts arranged at intervals between the root and the edge part along a circumferential direction of the skirt body, and the collapsing part being configured as a long strip structure extending along a radial direction of the skirt body, characterized in that along a thickness direction of the skirt body, the collapsing part protrudes relative to the skirt body on a first side surface of the skirt body, and is recessed relative to the skirt body on a second side surface of the skirt body and in that on the first side surface of the skirt body, a size of a portion of the collapsing part protruding from the skirt body gradually decreases from the root to the edge part. a root connected to the inner ring; an edge part arranged at an end of the skirt body away from the inner ring, a diameter of the edge part being larger than a diameter of the root; and a plurality of collapsing parts arranged at intervals between the root and the edge part along a circumferential direction of the skirt body, and the collapsing part being configured as a long strip structure extending along a radial direction of the skirt body, characterized in that along a thickness direction of the skirt body, the collapsing part protrudes relative to the skirt body on a first side surface of the skirt body, and is recessed relative to the skirt body on a second side surface of the skirt body and in that on the first side surface of the skirt body, a size of a portion of the collapsing part protruding from the skirt body gradually decreases from the root to the edge part.