A compound satisfying formula I, N -oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; wherein each X independently is C or N; at least one X = N; each Y independently is C or N; R 1 is present when X = C and R 1 is selected from the group of H, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, N(R 5) 2, CO(R 6), CH 2 NH 2, CH 2 OH, CN, C(=NOH)NH 2, C(=NOCH 3)NH 2, C(=NH)NH 2, CF 3, OCF 3, and B 2; B(O-C 1 -C 6 alkyl) 2; R 1 is absent when X = N R 2 -(CR 7 R 8) n -R 9; R 3 is selected from the group consisting of H, C 1 -C 10 alkyl optionally including a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C 3 -C 7 cycloalkyl, C 2 -C 10 alkenyl, SO 2 -R 7, CH 2 CF 3 or a 4 to 6 membered saturated ring containing an oxygen atom; R 4 is present where Y is C and is selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 alkoxy, CO(R 7), COO(R 7), CF 3 and halogen, R 5 is selected from the group consisting of H, C 1 -C 6 alkyl, COOCH 3, and CONHSO 2 CH 3; R 6 is selected from the group consisting of OH, O(C 1 -C 6 alkyl), NH 2, NHSO 2 N(C 1 -C 6 alkyl) 2, NHSO 2 NHCH 3, NHSO 2 (C 1 -C 6 alkyl), NHSO 2 (C 3 -C 7 cycloalkyl), and N(C 1 -C 6 -alkyl) 2; R 7 and R 8 are each independently chosen from H, C 1 -C 10 alkyl optionally including a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C 3 -C 7 cycloalkyl or R 7 and R 8 taken together form a 4 to 6 membered aliphatic ring that optionally contains a heteroatom selected from the group N, S, O; R 9 is selected from the group consisting of H, R 10, C 1 -C 6 alkyl, OH, CN, F, CF 2 H, CF 3, CONR 7 R 8, COOR 7, CON(R 7)SO 2 R 8, CON(R 7)SO 2 N(R 7 R 8), NR 7 R 8, NR 7 COOR 8, OCOR 7, O-Benzyl, NR 7 SO 2 R 8, SO 2 NR 7 R 8, SO 2 R 7, OCONR 7 R 8, OCONR 7 R 10, N(R 7)CON(R 7 R 8), N(R 7)COOR 10; phtalimido, 2-methyl-benzothiophene(1,1)dioxide, or a 4 to 6 membered saturated ring containing an oxygen atom; n is an integer from 2 to 6; R 10 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, phenyl, pyridine or pyrazole, optionally substituted with one or more substituents selected from the group comprising CF 3, CH 3, OCH 3, OCF 3 or halogen. wherein each X independently is C or N; at least one X = N; each Y independently is C or N; R 1 is present when X = C and R 1 is selected from the group of H, halogen, C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, N(R 5) 2, CO(R 6), CH 2 NH 2, CH 2 OH, CN, C(=NOH)NH 2, C(=NOCH 3)NH 2, C(=NH)NH 2, CF 3, OCF 3, and B 2; B(O-C 1 -C 6 alkyl) 2; R 1 is absent when X = N R 2 -(CR 7 R 8) n -R 9; R 3 is selected from the group consisting of H, C 1 -C 10 alkyl optionally including a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C 3 -C 7 cycloalkyl, C 2 -C 10 alkenyl, SO 2 -R 7, CH 2 CF 3 or a 4 to 6 membered saturated ring containing an oxygen atom; R 4 is present where Y is C and is selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, C 1 -C 6 alkoxy, CO(R 7), COO(R 7), CF 3 and halogen, R 5 is selected from the group consisting of H, C 1 -C 6 alkyl, COOCH 3, and CONHSO 2 CH 3; R 6 is selected from the group consisting of OH, O(C 1 -C 6 alkyl), NH 2, NHSO 2 N(C 1 -C 6 alkyl) 2, NHSO 2 NHCH 3, NHSO 2 (C 1 -C 6 alkyl), NHSO 2 (C 3 -C 7 cycloalkyl), and N(C 1 -C 6 -alkyl) 2; R 7 and R 8 are each independently chosen from H, C 1 -C 10 alkyl optionally including a cycloalkyl moiety selected from methylcyclopropyl or ethylcyclopropyl, C 3 -C 7 cycloalkyl or R 7 and R 8 taken together form a 4 to 6 membered aliphatic ring that optionally contains a heteroatom selected from the group N, S, O; R 9 is selected from the group consisting of H, R 10, C 1 -C 6 alkyl, OH, CN, F, CF 2 H, CF 3, CONR 7 R 8, COOR 7, CON(R 7)SO 2 R 8, CON(R 7)SO 2 N(R 7 R 8), NR 7 R 8, NR 7 COOR 8, OCOR 7, O-Benzyl, NR 7 SO 2 R 8, SO 2 NR 7 R 8, SO 2 R 7, OCONR 7 R 8, OCONR 7 R 10, N(R 7)CON(R 7 R 8), N(R 7)COOR 10; phtalimido, 2-methyl-benzothiophene(1,1)dioxide, or a 4 to 6 membered saturated ring containing an oxygen atom; n is an integer from 2 to 6; R 10 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, phenyl, pyridine or pyrazole, optionally substituted with one or more substituents selected from the group comprising CF 3, CH 3, OCH 3, OCF 3 or halogen.