A compound of Formula: or a pharmaceutically acceptable salt thereof; wherein: ----- represents a single or double bond; R 1 is C 1-6 alkyl optionally substituted with alkoxy or one to two halo groups (e.g., fluoro); R is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, or -OR A2, wherein R A2 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl; R 3a is hydrogen or -OR A3, wherein R A3 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, and R 3b is hydrogen; or R 3a and R 3b are joined to form an oxo (=O) group; each instance of R 4a and R 4b is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, or halogen, provided if the ----- between C5 and C6 is a single bond, then the hydrogen at C5 and R 4a are each independently provided in the alpha or beta configuration, and R 4b is absent; each instance of R 5, R 6, and R 7 is, independently, hydrogen, halogen, -NO 2, -CN, -OR GA,-N(R GA) 2, -C(=O)R GA, -C(=O)OR GA, -OC(=O)R GA, -OC(=O)OR GA, -C(=O)N(R GA) 2,-N(R GA)C(=O)R GA, -OC(=O)N(R GA) 2, -N(R GA)C(=O)OR GA, -N(R GA)C(=O)N(R GA) 2, -SR GA, -S(=O) R GA, -S(=O) 2 R GA, -S(=O) 2 OR GA, -OS(=O) 2 R GA, -S(=O) 2 N(R GA) 2, -N(R GA)S(=O) 2 R GA, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocylyl, or substituted or unsubstituted 3- to 6-membered heterocylyl; and at least one of R 5, R 6, and R 7 is halogen (e.g., -F, -Cl, -Br), -NO 2, -CN, -OR GA,-N(R GA) 2, -C(=O)R GA, -C(=O)OR GA, -SR GA, -S R GA, -S(=O) 2 R GA,-S(=O) 2 OR GA, -OS(=O) 2 R GA, -S(=O) 2 N(R GA) 2, substituted or unsubstituted C 1-6 alkyl (e.g., -CH 3,-CH 2 CH 3, haloalkyl, e.g., -CF 3), wherein R GA is substituted or unsubstituted C 1-2 alkyl; and each instance of R GA is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocylyl, substituted or unsubstituted 3- to 6- membered heterocylyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, nitrogen protecting group when attached to nitrogen, or two R GA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocylyl or heteroaryl ring. ----- represents a single or double bond; R 1 is C 1-6 alkyl optionally substituted with alkoxy or one to two halo groups (e.g., fluoro); R is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocyclyl, or -OR A2, wherein R A2 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl; R 3a is hydrogen or -OR A3, wherein R A3 is hydrogen or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, or substituted or unsubstituted C 3-6 carbocyclyl, and R 3b is hydrogen; or R 3a and R 3b are joined to form an oxo (=O) group; each instance of R 4a and R 4b is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, or halogen, provided if the ----- between C5 and C6 is a single bond, then the hydrogen at C5 and R 4a are each independently provided in the alpha or beta configuration, and R 4b is absent; each instance of R 5, R 6, and R 7 is, independently, hydrogen, halogen, -NO 2, -CN, -OR GA,-N(R GA) 2, -C(=O)R GA, -C(=O)OR GA, -OC(=O)R GA, -OC(=O)OR GA, -C(=O)N(R GA) 2,-N(R GA)C(=O)R GA, -OC(=O)N(R GA) 2, -N(R GA)C(=O)OR GA, -N(R GA)C(=O)N(R GA) 2, -SR GA, -S(=O) R GA, -S(=O) 2 R GA, -S(=O) 2 OR GA, -OS(=O) 2 R GA, -S(=O) 2 N(R GA) 2, -N(R GA)S(=O) 2 R GA, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocylyl, or substituted or unsubstituted 3- to 6-membered heterocylyl; and at least one of R 5, R 6, and R 7 is halogen (e.g., -F, -Cl, -Br), -NO 2, -CN, -OR GA,-N(R GA) 2, -C(=O)R GA, -C(=O)OR GA, -SR GA, -S R GA, -S(=O) 2 R GA,-S(=O) 2 OR GA, -OS(=O) 2 R GA, -S(=O) 2 N(R GA) 2, substituted or unsubstituted C 1-6 alkyl (e.g., -CH 3,-CH 2 CH 3, haloalkyl, e.g., -CF 3), wherein R GA is substituted or unsubstituted C 1-2 alkyl; and each instance of R GA is independently hydrogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted C 3-6 carbocylyl, substituted or unsubstituted 3- to 6- membered heterocylyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to oxygen, nitrogen protecting group when attached to nitrogen, or two R GA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocylyl or heteroaryl ring.