A liquid chromatography-mass spectrometry, LC-MS, apparatus comprising: an ionization source coupled to a mass spectrometer; a liquid chromatographic, LC, system coupled to the ionization source, wherein the LC system comprises multiple fluidic streams (11, 12, 13) alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream (11, 12, 13) from the multiple fluidic streams (11, 12, 13) when connected to the ionization source, wherein the LC system is configured to provide alternate connecting to the ionization source by switching between the multiple fluidic streams (11, 12, 13) at a constant pace, thereby assigning a detection time window of a fixed duration to each fluidic stream from the multiple fluidic streams (11, 12, 13) when connected to the ionization source, or such that the assigned detection time window for at least one fluidic stream of the multiple fluidic streams differs from the detection time window assigned to others fluidic streams of the multiple fluidic streams, wherein the apparatus further comprises a controller that is configured to carry out steps of: monitoring an ionization current of the ionization source for the multiple fluidic streams (11, 12, 13); identifying differences in flow conditions between the multiple fluidic streams (11, 12, 13) based on the monitored ionization current; adjusting detection conditions of one or more of the multiple fluidic streams (11, 12, 13) responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream (11, 12, 13) to be detected by the mass spectrometer in the respective detection time window. an ionization source coupled to a mass spectrometer; a liquid chromatographic, LC, system coupled to the ionization source, wherein the LC system comprises multiple fluidic streams (11, 12, 13) alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream (11, 12, 13) from the multiple fluidic streams (11, 12, 13) when connected to the ionization source, wherein the LC system is configured to provide alternate connecting to the ionization source by switching between the multiple fluidic streams (11, 12, 13) at a constant pace, thereby assigning a detection time window of a fixed duration to each fluidic stream from the multiple fluidic streams (11, 12, 13) when connected to the ionization source, or such that the assigned detection time window for at least one fluidic stream of the multiple fluidic streams differs from the detection time window assigned to others fluidic streams of the multiple fluidic streams, wherein the apparatus further comprises a controller that is configured to carry out steps of: monitoring an ionization current of the ionization source for the multiple fluidic streams (11, 12, 13); identifying differences in flow conditions between the multiple fluidic streams (11, 12, 13) based on the monitored ionization current; adjusting detection conditions of one or more of the multiple fluidic streams (11, 12, 13) responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream (11, 12, 13) to be detected by the mass spectrometer in the respective detection time window. monitoring an ionization current of the ionization source for the multiple fluidic streams (11, 12, 13); identifying differences in flow conditions between the multiple fluidic streams (11, 12, 13) based on the monitored ionization current; adjusting detection conditions of one or more of the multiple fluidic streams (11, 12, 13) responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream (11, 12, 13) to be detected by the mass spectrometer in the respective detection time window.