Air conditioning system (100, 200, 300, 500) for controlling conditions in an enclosed space (102, 202, 302, 502, 802, 902, 1002), the conditioning system comprising: a first cooling system (101, 201, 301, 501) to be disposed outside of the enclosed space (102, 202, 302, 502, 802, 902, 1002), the first cooling system comprising: a scavenger air plenum (104, 204, 304, 504) having an air inlet (106, 206, 306, 506) and an air outlet (108, 208, 308, 508), the plenum configured to direct scavenger air in an air flow path from the air inlet to the air outlet; a liquid to air membrane energy exchanger, LAMEE (110, 210, 310, 510), arranged inside the plenum (104, 204, 304, 504), the LAMEE comprising a water flow path separated from the air flow path by a membrane, the LAMEE configured to use the scavenger air to reduce a temperature of water in the water flow path; a cooling unit (112, 212, 312, 512) arranged inside the plenum (104, 204, 304, 504) downstream of the LAMEE (110, 210, 310, 510) and configured to use the scavenger air to cool the water; and a second cooling system (800, 900, 1000) to be disposed inside the enclosed space (102, 202, 302, 502, 802, 902, 1002); and a cooling fluid circuit connected to the water flow path of the LAMEE (110, 210, 310, 510) and to the second cooling system (800, 900, 1000), the cooling fluid circuit providing cooling to the enclosed space (102, 202, 302, 502, 802, 902, 1002) without moving air from the enclosed space through the first cooling system (101, 201, 301, 501). a first cooling system (101, 201, 301, 501) to be disposed outside of the enclosed space (102, 202, 302, 502, 802, 902, 1002), the first cooling system comprising: a scavenger air plenum (104, 204, 304, 504) having an air inlet (106, 206, 306, 506) and an air outlet (108, 208, 308, 508), the plenum configured to direct scavenger air in an air flow path from the air inlet to the air outlet; a liquid to air membrane energy exchanger, LAMEE (110, 210, 310, 510), arranged inside the plenum (104, 204, 304, 504), the LAMEE comprising a water flow path separated from the air flow path by a membrane, the LAMEE configured to use the scavenger air to reduce a temperature of water in the water flow path; a cooling unit (112, 212, 312, 512) arranged inside the plenum (104, 204, 304, 504) downstream of the LAMEE (110, 210, 310, 510) and configured to use the scavenger air to cool the water; and a scavenger air plenum (104, 204, 304, 504) having an air inlet (106, 206, 306, 506) and an air outlet (108, 208, 308, 508), the plenum configured to direct scavenger air in an air flow path from the air inlet to the air outlet; a liquid to air membrane energy exchanger, LAMEE (110, 210, 310, 510), arranged inside the plenum (104, 204, 304, 504), the LAMEE comprising a water flow path separated from the air flow path by a membrane, the LAMEE configured to use the scavenger air to reduce a temperature of water in the water flow path; a cooling unit (112, 212, 312, 512) arranged inside the plenum (104, 204, 304, 504) downstream of the LAMEE (110, 210, 310, 510) and configured to use the scavenger air to cool the water; and a second cooling system (800, 900, 1000) to be disposed inside the enclosed space (102, 202, 302, 502, 802, 902, 1002); and a cooling fluid circuit connected to the water flow path of the LAMEE (110, 210, 310, 510) and to the second cooling system (800, 900, 1000), the cooling fluid circuit providing cooling to the enclosed space (102, 202, 302, 502, 802, 902, 1002) without moving air from the enclosed space through the first cooling system (101, 201, 301, 501).