mhurhangee/ep-ind-claims huggingface dataset:
A therapeutic drug, comprising a CBP/catenin inhibitor and an immune checkpoint inhibitor in combination for use in treating cancer, wherein the CBP/catenin inhibitor is one or more kinds selected from the following compounds: (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide (ICG-001), 4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate, (6S,9S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide, and (6S,9aS)-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-((2-fluoro-4-hydroxyphenyl)methyl)-4,7-dioxo-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide and the immune checkpoint inhibitor is one or more kinds selected from anti-PD-1 antibody, anti-PD-L1 antibody and anti CTLA-4 antibody.
A gas turbine engine sealing system, comprising: a case including forward and aft hooks (62, 64), the aft hook arranged radially outward of the forward hook; and a blade outer air seal having a J-hook receiving the aft hook and an end received by the forward hook, characterised in that: the system further comprises first and second stator vanes, each stator vane having a forward and aft rail (94, 92), wherein the blade outer air seal includes forward and aft seals (74, 76) respectively secured to the end and the J-hook, the aft seal engaging the forward rail of the second stator vane, the aft seal including a radially inwardly extending flange that engages the forward rail of the second stator vane; and the blade outer air seal includes an outer diameter side, and a spring is supported on the outer diameter side and engages the aft hook to bias the blade outer air seal radially inward. a case including forward and aft hooks (62, 64), the aft hook arranged radially outward of the forward hook; and a blade outer air seal having a J-hook receiving the aft hook and an end received by the forward hook, the system further comprises first and second stator vanes, each stator vane having a forward and aft rail (94, 92), wherein the blade outer air seal includes forward and aft seals (74, 76) respectively secured to the end and the J-hook, the aft seal engaging the forward rail of the second stator vane, the aft seal including a radially inwardly extending flange that engages the forward rail of the second stator vane; and the blade outer air seal includes an outer diameter side, and a spring is supported on the outer diameter side and engages the aft hook to bias the blade outer air seal radially inward.
A clip comprising: a pair of opposed gripping portions (18, 20) each having a gripping surface (22, 24), each gripping portion being located on a clip half (12, 14), wherein the clip halves (12, 14) are biased by a biasing component; characterised in that one clip half further includes a stop spaced apart from the gripping portion which is engageable with a point spaced apart from the gripping portion on the other clip half, wherein the clip halves (12, 14) are biased by the biasing component to urge the stop against the point on the other clip half so as to prevent the gripping surfaces (22, 24) from being urged together by the force exerted by the biasing component. a pair of opposed gripping portions (18, 20) each having a gripping surface (22, 24), each gripping portion being located on a clip half (12, 14), wherein the clip halves (12, 14) are biased by a biasing component; characterised in that one clip half further includes a stop spaced apart from the gripping portion which is engageable with a point spaced apart from the gripping portion on the other clip half, wherein the clip halves (12, 14) are biased by the biasing component to urge the stop against the point on the other clip half so as to prevent the gripping surfaces (22, 24) from being urged together by the force exerted by the biasing component.
Metal gantry for supporting a lifting device for transporting materials, comprising: a telescopic structure comprising an outer tube and an inner tube; an arm (8, 14, 16, 17) connected to the outer tube for the displacement of the lifting device transverse to the telescopic structure; wherein the arm comprises a rail and a trolley to slide in the rail and support the lifting device; and a nut for threading at an end of the outer tube; characterised in that the metal gantry further comprises a shaft to hold the inner tube within the outer tube in said nut; wherein the arm is rotatably connected to the outer tube; wherein the outer tube comprises a base at the lower end for resting on a floor and a thread at the upper end for said nut; wherein the inner tube comprises a bearing for securing to the ceiling of a slab and a plurality of holes for fitting said shaft and holding the inner tube within the outer tube. a telescopic structure comprising an outer tube and an inner tube; an arm (8, 14, 16, 17) connected to the outer tube for the displacement of the lifting device transverse to the telescopic structure; wherein the arm comprises a rail and a trolley to slide in the rail and support the lifting device; and a nut for threading at an end of the outer tube; characterised in that the metal gantry further comprises a shaft to hold the inner tube within the outer tube in said nut; wherein the arm is rotatably connected to the outer tube; wherein the outer tube comprises a base at the lower end for resting on a floor and a thread at the upper end for said nut; wherein the inner tube comprises a bearing for securing to the ceiling of a slab and a plurality of holes for fitting said shaft and holding the inner tube within the outer tube.
A fixing for attaching an object to a panel, the fixing comprising: a head member configured to be located on a first side of the panel; a back member configured to be located on a second side of the panel and to receive at least part of an attachment element; and a neck member connecting the head member and the back member, wherein the head member, neck member, and back member are rigidly coupled together and a part of the back member extends radially outwardly with respect to the head member, such that the back member is locatable on the second side of the panel by manipulation of the rigidly coupled head member, neck member and back member, characterised in that the back member defines a plurality of apertures. a head member configured to be located on a first side of the panel; a back member configured to be located on a second side of the panel and to receive at least part of an attachment element; and a neck member connecting the head member and the back member, wherein the head member, neck member, and back member are rigidly coupled together and a part of the back member extends radially outwardly with respect to the head member, such that the back member is locatable on the second side of the panel by manipulation of the rigidly coupled head member, neck member and back member, characterised in that the back member defines a plurality of apertures.
A windscreen wiper arm, particularly for automobiles, comprising a mounting head mountable on a drive shaft and an arm member pivotally connected to the mounting head by means of a pivot pin, wherein the arm member has a substantially U-shaped cross-section near said pivot pin comprising two side walls (16,17), wherein a part of the mounting head extends between the side walls (16, 17) and beyond said pivot pin, wherein said part is provided with opposite abutting surfaces (20,21) for abutting against the side walls (16,17) of the arm member, wherein means are provided on said mounting head and said arm member for limiting a pivot angle of the arm member, characterized in that said means comprise at least one guiding groove on one of said abutting surfaces (20,21) of said part of said mounting head, as well as at least one outwardly extending finger on said arm member cooperating with said guiding groove, wherein said finger is movable in said guiding groove between a first position corresponding with a wiping position of the arm member and a second position corresponding with a mounting position of the arm member, and wherein said finger extends outwardly from a base of the U-shaped cross-section of said arm member in a direction towards said drive shaft.
A method of controlling connection of a supply of AC power to a load and to a power supply grid, the supply of AC power being generated by an AC power generating system of the kind that comprises a source of power (1,2) arranged to provide an electrical output, converter means for generating an AC power output to supply the load from the electrical output, and control means which are operable to control the operation of the converter means and thereby to supply the power required to the load both when the AC power output of the AC power generating system is connected to the power supply grid as well as to the load and during independent operation of the AC power generating system to supply the load including in the event of disconnection of the AC power output from the power supply grid, the control means being operable in response to signals (I ina, V aca) derived from sensed current and/or voltage of an electrical output (V acc) which is generated by the converter means from the electrical output (V g) of the source of power, wherein the current and voltage of the AC power output and the voltage (V acg) of the power supply grid are monitored, wherein one reference which is used as a reference in the operation of the converter means to control the generation of the AC power output during independent operation of the AC power generating system to supply the load is replaced by another reference which is derived from the monitored grid voltage when the AC power output is to be connected to the power supply grid such that generation of the AC power output by the converter means is controlled in accordance with said another reference when the AC power output of the AC power generating system is connected to the power supply grid as well as supplying the power required by the load, characterized in that said one reference is derived from the monitored AC power output voltage.
A system (1,21) for assigning a light device to an entertainment group in a lighting system (10,20), said lighting system (10,20) comprising a plurality of commissioned light devices and said entertainment group comprising one or more of said plurality of commissioned light devices, currently available light devices in said entertainment group being controlled to render light effects synchronized to media content in an entertainment mode, said system comprising: - at least one input interface (3,23); - at least one output interface (4,24); and - at least one processor (5,25) configured to: - use said at least one input interface (3,23) to detect that a light device has been added to said lighting system (10,20), said light device not being commissioned into said lighting system (10,20), - determine whether said entertainment mode is active, the system (1, 21) being characterized in that the at least one processor (5, 25) is further configured to: - add said light device to said entertainment group upon detecting that said light device has been added to said lighting system (10,20) in dependence on said entertainment mode being active, - use said at least one output interface (4,24) to control said light device to render one or more light effects synchronized to said media content in said entertainment mode after said light device has been added to said entertainment group, - use said at least one input interface (3,23) to detect that said light device is unavailable, and - remove said light device from said entertainment group upon detecting that said light device is unavailable. - at least one input interface (3,23); - at least one output interface (4,24); and - at least one processor (5,25) configured to: - use said at least one input interface (3,23) to detect that a light device has been added to said lighting system (10,20), said light device not being commissioned into said lighting system (10,20), - determine whether said entertainment mode is active, - add said light device to said entertainment group upon detecting that said light device has been added to said lighting system (10,20) in dependence on said entertainment mode being active, - use said at least one output interface (4,24) to control said light device to render one or more light effects synchronized to said media content in said entertainment mode after said light device has been added to said entertainment group, - use said at least one input interface (3,23) to detect that said light device is unavailable, and - remove said light device from said entertainment group upon detecting that said light device is unavailable.
A method of operating a base station for communicating data between the base station and a plurality of terminal devices in a wireless telecommunications system using a plurality of Orthogonal Frequency Division Multiplex, OFDM, sub-carriers spanning a first frequency bandwidth, the method comprising: communicating user-plane data using a first group of the OFDM sub-carriers distributed across the first frequency bandwidth; communicating no user-plane data using a second group of the OFDM sub-carriers distributed across a second frequency bandwidth, wherein the second frequency bandwidth is smaller than and within the first frequency bandwidth; and communicating control-plane data with the plurality of terminal devices using a combination of the first and second groups of the OFDM sub-carriers, wherein a lower amount of user-plane data is communicated using OFDM sub-carriers arranged in frequency at a boundary between OFDM sub-carriers in the first group and OFDM sub-carriers in the second group as compared to an amount of user-plane data communicated using OFDM sub-carriers away from this boundary. communicating user-plane data using a first group of the OFDM sub-carriers distributed across the first frequency bandwidth; communicating no user-plane data using a second group of the OFDM sub-carriers distributed across a second frequency bandwidth, wherein the second frequency bandwidth is smaller than and within the first frequency bandwidth; and communicating control-plane data with the plurality of terminal devices using a combination of the first and second groups of the OFDM sub-carriers, wherein a lower amount of user-plane data is communicated using OFDM sub-carriers arranged in frequency at a boundary between OFDM sub-carriers in the first group and OFDM sub-carriers in the second group as compared to an amount of user-plane data communicated using OFDM sub-carriers away from this boundary.
Combined machine, such as compressor-pump or similar, comprising motor means and a plurality of operating machines (H, C, V) that can be powered in an independent manner by said motor means, wherein: - the combined machine comprises a transmission box, placed between the motor means and said operating machines (H, C, V), that comprises an inlet shaft connected to said motor means and a plurality of outlet shafts (4a-4c) connected respectively to said operating machines (H, C, V); - said transmission box comprises at least a freewheel bearing (5a-5c) arranged to drive a respective outlet shaft (4a-4c); - the combined machine furthermore comprises means (S, D) for reversing the rotation direction given by said motor means to said inlet shaft of the transmission box, characterised in that: - said inlet shaft and said outlet shafts are aligned in the same direction; - the transmission box is geared, comprising a plurality of gear wheels (8a-8c), each of which is mounted directly on a respective freewheel bearing (5a-5c). - the combined machine comprises a transmission box, placed between the motor means and said operating machines (H, C, V), that comprises an inlet shaft connected to said motor means and a plurality of outlet shafts (4a-4c) connected respectively to said operating machines (H, C, V); - said transmission box comprises at least a freewheel bearing (5a-5c) arranged to drive a respective outlet shaft (4a-4c); - the combined machine furthermore comprises means (S, D) for reversing the rotation direction given by said motor means to said inlet shaft of the transmission box, - said inlet shaft and said outlet shafts are aligned in the same direction; - the transmission box is geared, comprising a plurality of gear wheels (8a-8c), each of which is mounted directly on a respective freewheel bearing (5a-5c).
Method for producing a sealing strand that is extruded in the manner of a tube with a cavity and is reinforced in some locations, wherein a material that reinforces the sealing strand, is flowable and solidifies in the cavity to form an elastically deformable material (13, 14) is introduced into the cavity at at least one predetermined longitudinal position of the sealing strand and the solidified material is fixed in the cavity in the longitudinal direction of the strand by form closure with the cavity wall, characterized in that, for fixing the solidified material by form closure with the cavity wall, periodically recurring projections that project into the cavity are formed by variable extrusion of the sealing strand.
A sheet membrane for repairing a damaged tissue, comprising an isotropic layer of cross-linked collagen-based fibers having a laminated multi-layered structure with a density of 0.1 to 1.2 g/cm 3, wherein the fibers are 10 to 1,000 cm in length.
A gas turbine engine system comprising: an aircraft fuel system; a fuel conditioner; and a gas turbine engine assembly comprising a gas turbine engine and a fuel module; wherein the fuel conditioner comprises: an ice debris separator configured to receive a fuel flow from the aircraft fuel system; characterised in that it further comprises a fuel pump in fluid communication with the ice debris separator, wherein the fuel pump is downstream of the ice debris separator and configured to receive filtered fuel and output pressurized fuel; a heat exchanger in fluid communication with the fuel pump, wherein the heat exchanger is downstream from the fuel pump and upstream of the fuel module of the gas turbine engine assembly, and wherein the heat exchanger is configured to receive a pressurized fuel flow output from the fuel pump and output a heated fuel flow; and wherein the fuel pump is a motive flow pump configured to combine the fuel flow from the ice debris separator and a motive fuel flow from the fuel module. an aircraft fuel system; a fuel conditioner; and a gas turbine engine assembly comprising a gas turbine engine and a fuel module; wherein the fuel conditioner comprises: an ice debris separator configured to receive a fuel flow from the aircraft fuel system; characterised in that it further comprises a fuel pump in fluid communication with the ice debris separator, wherein the fuel pump is downstream of the ice debris separator and configured to receive filtered fuel and output pressurized fuel; a heat exchanger in fluid communication with the fuel pump, wherein the heat exchanger is downstream from the fuel pump and upstream of the fuel module of the gas turbine engine assembly, and wherein the heat exchanger is configured to receive a pressurized fuel flow output from the fuel pump and output a heated fuel flow; and wherein the fuel pump is a motive flow pump configured to combine the fuel flow from the ice debris separator and a motive fuel flow from the fuel module. an ice debris separator configured to receive a fuel flow from the aircraft fuel system; characterised in that it further comprises a fuel pump in fluid communication with the ice debris separator, wherein the fuel pump is downstream of the ice debris separator and configured to receive filtered fuel and output pressurized fuel; a heat exchanger in fluid communication with the fuel pump, wherein the heat exchanger is downstream from the fuel pump and upstream of the fuel module of the gas turbine engine assembly, and wherein the heat exchanger is configured to receive a pressurized fuel flow output from the fuel pump and output a heated fuel flow; and wherein the fuel pump is a motive flow pump configured to combine the fuel flow from the ice debris separator and a motive fuel flow from the fuel module.
A head-up display device that is to be mounted in a moving vehicle and enables an occupant in the moving vehicle to view a virtual image based on a reflected image of S-polarized light in a projection section, the head-up display device comprising: an image projector configured to apply projection light including S-polarized light; and the projection section on which the projection light is to be projected, the projection section comprising laminated glass including a first glass plate defining a surface of the laminated glass on which the projection light is to be incident, a second glass plate defining a surface of the laminated glass from which the projection light is to be emitted, and a half-wave plate disposed between the first glass plate and the second glass plate, the first glass plate and the second glass plate each being formed from a glass composition containing silicon oxide, iron oxide, and an alkali metal oxide, at least one of the first glass plate or the second glass plate having a thickness of 0.3 mm to 3 mm, a total iron oxide content in terms of Fe 2 O 3 in the glass composition of 0.2% by mass to 2.0% by mass, and a FeO content of 0.1% by mass to 0.5% by mass, the half-wave plate having visible light transmissivity and being configured to transmit light with an a* value of -2.5 to 4.5 and a b* value of -1.0 to 7.0 in a CIE color system, the reflected image being formed on a surface of the first glass plate which is to face an inside of the vehicle, the second glass plate being configured to emit from a surface thereof which is to face an outside of the vehicle the projection light converted to P-polarized light. an image projector configured to apply projection light including S-polarized light; and the projection section on which the projection light is to be projected, the projection section comprising laminated glass including a first glass plate defining a surface of the laminated glass on which the projection light is to be incident, a second glass plate defining a surface of the laminated glass from which the projection light is to be emitted, and a half-wave plate disposed between the first glass plate and the second glass plate, the first glass plate and the second glass plate each being formed from a glass composition containing silicon oxide, iron oxide, and an alkali metal oxide, at least one of the first glass plate or the second glass plate having a thickness of 0.3 mm to 3 mm, a total iron oxide content in terms of Fe 2 O 3 in the glass composition of 0.2% by mass to 2.0% by mass, and a FeO content of 0.1% by mass to 0.5% by mass, the half-wave plate having visible light transmissivity and being configured to transmit light with an a* value of -2.5 to 4.5 and a b* value of -1.0 to 7.0 in a CIE color system, the reflected image being formed on a surface of the first glass plate which is to face an inside of the vehicle, the second glass plate being configured to emit from a surface thereof which is to face an outside of the vehicle the projection light converted to P-polarized light.