A method of applying a buttress to a wet surgical stapler end effector with a humidity tolerant adhesive, the method comprising the steps of: (a) positioning a buttress assembly (100, 110) between an anvil and a staple cartridge of the end effector, wherein the buttress assembly comprises: (i) a buttress body (102, 112), and (ii) a humidity tolerant adhesive material (104, 114) applied to at least one side of the buttress body, wherein the humidity tolerant adhesive material faces either an underside of the anvil or a deck of the staple cartridge, wherein the anvil is in an open position relative to the staple cartridge during the act of positioning the buttress assembly between the anvil and the staple cartridge; (b) moving the anvil toward the staple cartridge; and (c) moving the anvil back to the open position, wherein the buttress assembly is adhered to the underside of the anvil or the deck of the staple cartridge via the humidity tolerant adhesive material with the anvil moved back to the open position, wherein the humidity tolerant adhesive material comprises polymers that are combined with a hydrocolloid of one or more sorbents to hold the buttress body to the underside of the anvil or the deck of the staple cartridge for at least five minutes in an environment of 100% relative humidity, wherein the polymers comprise copolymers selected from the group consisting of: polyethylene-polyethylene glycol copolymers; poly(caprolactone)-glycolide copolymers; and combinations thereof, and wherein the one or more sorbents are selected from a group consisting of: polysaccharides; cellulose derivatives; starch; starch derivates; natural gums; chitosan; pectin; gelatin; and combinations thereof. (a) positioning a buttress assembly (100, 110) between an anvil and a staple cartridge of the end effector, wherein the buttress assembly comprises: (i) a buttress body (102, 112), and (ii) a humidity tolerant adhesive material (104, 114) applied to at least one side of the buttress body, wherein the humidity tolerant adhesive material faces either an underside of the anvil or a deck of the staple cartridge, wherein the anvil is in an open position relative to the staple cartridge during the act of positioning the buttress assembly between the anvil and the staple cartridge; (i) a buttress body (102, 112), and (ii) a humidity tolerant adhesive material (104, 114) applied to at least one side of the buttress body, wherein the humidity tolerant adhesive material faces either an underside of the anvil or a deck of the staple cartridge, wherein the anvil is in an open position relative to the staple cartridge during the act of positioning the buttress assembly between the anvil and the staple cartridge; (b) moving the anvil toward the staple cartridge; and (c) moving the anvil back to the open position, wherein the buttress assembly is adhered to the underside of the anvil or the deck of the staple cartridge via the humidity tolerant adhesive material with the anvil moved back to the open position, wherein the humidity tolerant adhesive material comprises polymers that are combined with a hydrocolloid of one or more sorbents to hold the buttress body to the underside of the anvil or the deck of the staple cartridge for at least five minutes in an environment of 100% relative humidity, wherein the polymers comprise copolymers selected from the group consisting of: polyethylene-polyethylene glycol copolymers; poly(caprolactone)-glycolide copolymers; and combinations thereof, and wherein the one or more sorbents are selected from a group consisting of: polysaccharides; cellulose derivatives; starch; starch derivates; natural gums; chitosan; pectin; gelatin; and combinations thereof.