A system comprising: an oscillatory ventilator configured for oscillating a ventilation gas for delivery to a lung region of a patient; a ventilator control system, in communication with the oscillatory ventilator, to control a waveform input for the oscillatory ventilator; at least one sensor for measuring the ventilation gas being delivered to the lung region of the patient and providing the measurement to the ventilator control system for use in producing the waveform input; and wherein the ventilator control system further comprises an input device for receiving a measurement from the at least one sensor, and further comprises an output device for providing the waveform input to the oscillatory ventilator, and further a computer in communication with the input device for processing information from the input device, and in communication with the output device for controlling the oscillatory ventilator; wherein the input device is configured for receiving at least one measurement corresponding to physiological characteristics of the patient, wherein the physiological characteristics include at least one chosen from, V̇/Q̇ airway pressure, airway flow, mechanical impedance, delivered concentration of gas species, ventilation-to-perfusion ratio, ventilation distribution, pH, arterial tension of carbon dioxide, or arterial tension of oxygen; and wherein the computer is configured for executing stored software/firmware for controlling the operating parameters of the oscillatory ventilator; characterized in that the oscillatory ventilator is a multi-frequency oscillatory ventilator (MFOV) that is configured for oscillating the ventilation gas corresponding to the waveform input from the output device of the ventilator control system at a plurality of specifically tuned frequencies; in that the software/firmware is configured for controlling the operating parameters of the oscillatory ventilator including the frequencies, and including the amplitude, and including the phase characteristics of the applied waveform input; and in that the waveform input comprises a plurality (up to N) of sinusoidal waveforms each characterized by an amplitude, a frequency, and a phase, and wherein the frequencies, amplitudes, and phases of each of the plurality of sinusoidal waveforms are independently controlled in dependence of the measurements received by the input device from the at least one sensor. an oscillatory ventilator configured for oscillating a ventilation gas for delivery to a lung region of a patient; a ventilator control system, in communication with the oscillatory ventilator, to control a waveform input for the oscillatory ventilator; at least one sensor for measuring the ventilation gas being delivered to the lung region of the patient and providing the measurement to the ventilator control system for use in producing the waveform input; and wherein the ventilator control system further comprises an input device for receiving a measurement from the at least one sensor, and further comprises an output device for providing the waveform input to the oscillatory ventilator, and further a computer in communication with the input device for processing information from the input device, and in communication with the output device for controlling the oscillatory ventilator; wherein the input device is configured for receiving at least one measurement corresponding to physiological characteristics of the patient, wherein the physiological characteristics include at least one chosen from, V̇/Q̇ airway pressure, airway flow, mechanical impedance, delivered concentration of gas species, ventilation-to-perfusion ratio, ventilation distribution, pH, arterial tension of carbon dioxide, or arterial tension of oxygen; and wherein the computer is configured for executing stored software/firmware for controlling the operating parameters of the oscillatory ventilator; characterized in that the oscillatory ventilator is a multi-frequency oscillatory ventilator (MFOV) that is configured for oscillating the ventilation gas corresponding to the waveform input from the output device of the ventilator control system at a plurality of specifically tuned frequencies; in that the software/firmware is configured for controlling the operating parameters of the oscillatory ventilator including the frequencies, and including the amplitude, and including the phase characteristics of the applied waveform input; and in that the waveform input comprises a plurality (up to N) of sinusoidal waveforms each characterized by an amplitude, a frequency, and a phase, and wherein the frequencies, amplitudes, and phases of each of the plurality of sinusoidal waveforms are independently controlled in dependence of the measurements received by the input device from the at least one sensor.