mhurhangee/ep-ind-claims huggingface dataset:
An aqueous pharmaceutical formulation comprising: - an anti-RANKL antibody, or antigen-binding portion thereof, at a concentration in a range of 100 to 140 mg/mL; - 1.0 (w/w)% to 5.0 (w/w)% sorbitol; - at least 0.004 (w/v) % and less than 0.15 (w/v)% polysorbate 20 or polysorbate 80; - 5 mM to 60 mM acetate or glutamate buffer; and - 5 mM to 180 mM L-phenylalanine or L-tryptophan; wherein the aqueous pharmaceutical formulation has a pH in a range of 5.0 to 5.4; and wherein the anti-RANKL antibody, or antigen-binding portion thereof, comprises a light chain variable domain comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 5, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 6, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:7; and a heavy chain variable domain comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 8, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 9, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 10. - an anti-RANKL antibody, or antigen-binding portion thereof, at a concentration in a range of 100 to 140 mg/mL; - 1.0 (w/w)% to 5.0 (w/w)% sorbitol; - at least 0.004 (w/v) % and less than 0.15 (w/v)% polysorbate 20 or polysorbate 80; - 5 mM to 60 mM acetate or glutamate buffer; and - 5 mM to 180 mM L-phenylalanine or L-tryptophan; wherein the aqueous pharmaceutical formulation has a pH in a range of 5.0 to 5.4; and wherein the anti-RANKL antibody, or antigen-binding portion thereof, comprises a light chain variable domain comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 5, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 6, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:7; and a heavy chain variable domain comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 8, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 9, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 10.
An anti-skid device for a vehicle wheel comprising: - a first and a second portion (21, 22) of chain, flanked to one another and destined to extend along a development of a tread of the wheel; - a first support of the first and the second portion (21, 22) of chain, said first support being destined to at least partly superpose on a tread of the wheel; - at least a first connecting element for connecting the first and the second portion (21, 22) of chain, located at the first support, said first connecting element being a flexible bar; characterised in that said first connecting element crosses a link of the first portion of chain and a link of the second portion of chain; the first portion is part of a first chain; the first chain surrounding the rotation axis of the wheel without interruption; the second portion is part of a second chain; the second chain is closed on itself. - a first and a second portion (21, 22) of chain, flanked to one another and destined to extend along a development of a tread of the wheel; - a first support of the first and the second portion (21, 22) of chain, said first support being destined to at least partly superpose on a tread of the wheel; - at least a first connecting element for connecting the first and the second portion (21, 22) of chain, located at the first support, said first connecting element being a flexible bar; characterised in that said first connecting element crosses a link of the first portion of chain and a link of the second portion of chain; the first portion is part of a first chain; the first chain surrounding the rotation axis of the wheel without interruption; the second portion is part of a second chain; the second chain is closed on itself.
A method for generating navigation routes, the method comprising: obtaining, by processing hardware, route data indicative of a plurality of routes between respective starting locations and destinations, previously traversed by a user; identifying, by the processing hardware using map data, route segments of a first type and at least one other type within the plurality of routes, to generate route segment data; determining, by the processing hardware using the route data and the route segment data, a quantitative metric to measure a trade-off between a first property of the route segments of the first type route and a second property of route segments of the at least one other type in selection of navigation routes by the user; receiving, by the processing hardware, an indication of a starting location and a destination from the user; and generating, by the processing hardware a navigation route between the starting location and the destination for the user, including applying the quantitative metric to constrain selections of route segments; characterized in that the method further comprises determining the quantitative metric includes determining an amount of time by which a first route the user travelled between a pair of locations differs from a second route the user travelled between the pair of locations, wherein the first route includes route segments of the first type and the second route includes route segments of the at least one other type. obtaining, by processing hardware, route data indicative of a plurality of routes between respective starting locations and destinations, previously traversed by a user; identifying, by the processing hardware using map data, route segments of a first type and at least one other type within the plurality of routes, to generate route segment data; determining, by the processing hardware using the route data and the route segment data, a quantitative metric to measure a trade-off between a first property of the route segments of the first type route and a second property of route segments of the at least one other type in selection of navigation routes by the user; receiving, by the processing hardware, an indication of a starting location and a destination from the user; and generating, by the processing hardware a navigation route between the starting location and the destination for the user, including applying the quantitative metric to constrain selections of route segments; characterized in that the method further comprises determining the quantitative metric includes determining an amount of time by which a first route the user travelled between a pair of locations differs from a second route the user travelled between the pair of locations, wherein the first route includes route segments of the first type and the second route includes route segments of the at least one other type.
A soft and velvet touch barrier laminate comprising: (a) a printable layer comprising of polypropylene elastomer; (b) a core layer adjacent to the printable layer; (c) a laminating layer adjacent to the core layer; (d) a barrier layer between first and second bond layers, wherein the first bond layer is between the laminating layer and the barrier layer; and (e) an inner polyethylene layer adjacent to the second bond layer which is in contact with the barrier layer; wherein said polypropylene elastomer has Vicat softening temperature, measured according to the method in the description, in the range of 60°C to 90°C; and wherein the printable layer further comprises high density polyethylene (HDPE) an anti-block additive; and a colorant, wherein the printable layer optionally comprises polypropylene elastomer, high density polyethylene (HDPE), anti-block additive and the colorant in a blend ratio in the range of 26:70:2:2 to 60:25:5:10; and/or wherein the anti- block additive is optionally selected from the group consisting of ground silica, silicas, aluminosilicates, and metal aluminosilicates, preferably ground silica; and/or wherein the colorant is optionally selected from the group consisting of titanium dioxide (TiO 2), zinc sulfide (ZnS), zinc oxide (ZnO), barium sulfate (BaSO 4), carbon black and calcium carbonate (CaCO 3). (a) a printable layer comprising of polypropylene elastomer; (b) a core layer adjacent to the printable layer; (c) a laminating layer adjacent to the core layer; (d) a barrier layer between first and second bond layers, wherein the first bond layer is between the laminating layer and the barrier layer; and (e) an inner polyethylene layer adjacent to the second bond layer which is in contact with the barrier layer;
An optical frequency reference comprising: a first micro-resonator (306, 408) and a second micro-resonator (302, 402); and at least one pump laser configured to: pump the first micro-resonator (306, 408) to generate a fine optical frequency comb having a first tooth and a frequency spacing between teeth that is locked to a fractional or integer multiple of a radio frequency reference; and pump the second micro-resonator (302, 402) to generate a coarse optical frequency comb having a second tooth that is locked to the first tooth and a frequency spacing between teeth that is locked to an integer multiple of the FCS, wherein an absolute optical frequency of at least one tooth of the coarse optical frequency comb is set. a first micro-resonator (306, 408) and a second micro-resonator (302, 402); and at least one pump laser configured to: pump the first micro-resonator (306, 408) to generate a fine optical frequency comb having a first tooth and a frequency spacing between teeth that is locked to a fractional or integer multiple of a radio frequency reference; and pump the second micro-resonator (302, 402) to generate a coarse optical frequency comb having a second tooth that is locked to the first tooth and a frequency spacing between teeth that is locked to an integer multiple of the FCS, wherein an absolute optical frequency of at least one tooth of the coarse optical frequency comb is set. pump the first micro-resonator (306, 408) to generate a fine optical frequency comb having a first tooth and a frequency spacing between teeth that is locked to a fractional or integer multiple of a radio frequency reference; and pump the second micro-resonator (302, 402) to generate a coarse optical frequency comb having a second tooth that is locked to the first tooth and a frequency spacing between teeth that is locked to an integer multiple of the FCS, wherein an absolute optical frequency of at least one tooth of the coarse optical frequency comb is set.
Domestic appliance, in particular a floor treatment appliance, having an appliance housing, a fan arranged in the appliance housing, an outlet opening formed in the appliance housing behind the fan in the direction of flow, and a flow duct which connects the outlet opening to the fan in a flow-guiding manner, characterised in that in that a sound reduction wall is positioned in the flow duct, the wall plane of which is orientated parallel to a main flow direction (s) of the air flow guided in the flow duct, the sound reduction wall being arranged in the flow duct so as to be actively displaceable relative to a direction orthogonal to the main flow direction (s).
A system, comprising: a processor configured to: receive a test result, wherein the test result reflects a condition of a brain in a subject or a vagus nerve activity; and determine a stimulation parameter based on the test result; and a stimulator configured to: stimulate a first nerve based on the stimulation parameter, wherein stimulation of the first nerve assists or causes contraction of a respiratory muscle in the subject, and stimulate a second nerve, wherein stimulation of the second nerve establishes a nerve block or reduces inflammation. a processor configured to: receive a test result, wherein the test result reflects a condition of a brain in a subject or a vagus nerve activity; and determine a stimulation parameter based on the test result; and receive a test result, wherein the test result reflects a condition of a brain in a subject or a vagus nerve activity; and determine a stimulation parameter based on the test result; and a stimulator configured to: stimulate a first nerve based on the stimulation parameter, wherein stimulation of the first nerve assists or causes contraction of a respiratory muscle in the subject, and stimulate a second nerve, wherein stimulation of the second nerve establishes a nerve block or reduces inflammation. stimulate a first nerve based on the stimulation parameter, wherein stimulation of the first nerve assists or causes contraction of a respiratory muscle in the subject, and stimulate a second nerve, wherein stimulation of the second nerve establishes a nerve block or reduces inflammation.
A backlight device, wherein light emitted from a light source is output toward a rear face of a display panel, comprising: a prism film (13; 13a, 13b) including a first face on the display panel side and a second face opposing the first face, wherein a prism-like pattern is formed on the first face, and a reflector plate including a reflection face opposing the second face, wherein a scattering pattern is formed on the reflection face wherein, when a first normal line axis (41a, 41b) normal to a slope forming the prism-like pattern and a second normal line axis normal to one slope forming the scattering pattern are projected on an imaginary plane parallel to the reflection face of the reflector plate, the projected first and second normal line axes form an acute angle, wherein the scattering pattern comprises a plurality of pyramidal protrusions or recesses. a prism film (13; 13a, 13b) including a first face on the display panel side and a second face opposing the first face, wherein a prism-like pattern is formed on the first face, and a reflector plate including a reflection face opposing the second face, wherein a scattering pattern is formed on the reflection face wherein, when a first normal line axis (41a, 41b) normal to a slope forming the prism-like pattern and a second normal line axis normal to one slope forming the scattering pattern are projected on an imaginary plane parallel to the reflection face of the reflector plate, the projected first and second normal line axes form an acute angle, wherein the scattering pattern comprises a plurality of pyramidal protrusions or recesses.
A pharmaceutical composition for use in preventing or treating a granulosa cell tumor of the ovary, comprising: one selected from the group consisting of a compound represented by Formula 2, a pharmaceutically acceptable salt of the compound represented by Formula 2, a compound represented by Formula 1, and a pharmaceutically acceptable salt of the compound represented by Formula 1, as an active ingredient.
System for introducing a radially compressible part (1.1) of a catheter device into a sleeve, comprising a sleeve, a catheter device comprising a radially compressible part (1.1), the radially compressible part (1.1) being configured to be transferred at least in part into the sleeve; a compression pipe which comprises movable fins (2.2) for receiving the radially compressible part (1.1), the movable fins (2.2) having an open state and a closed state a reducer for radially compressing the movable fins (2.2) of the compression pipe and the radially compressible part (1.1) received between the movable fins (2.2). a sleeve, a catheter device comprising a radially compressible part (1.1), the radially compressible part (1.1) being configured to be transferred at least in part into the sleeve; a compression pipe which comprises movable fins (2.2) for receiving the radially compressible part (1.1), the movable fins (2.2) having an open state and a closed state a reducer for radially compressing the movable fins (2.2) of the compression pipe and the radially compressible part (1.1) received between the movable fins (2.2).
A method for typographically composing Arabic texts using detached letters and employing the independent form of the traditional Arabic letters, after the standardization of its form into a typographic structure, where the same sign comes in any position it takes in the word composition.
A method for air-to-ground data streaming, comprising: receiving avionics data, by a processor aboard an aircraft, from a line replaceable unit aboard the aircraft, the processor being configured to operate in a monitor mode and an event mode; encoding the avionics data according to a data map, wherein the data map is one of multiple data maps received from a ground station in the monitor mode or the event mode, wherein in the monitor mode the data map identifies a first minimal data set of the avionics data, and in the event mode the data map identifies a second expanded data set of the avionics data; processing, by the processor, substantially simultaneously, more than one data set via more than one data map of the multiple data maps to substantially simultaneously prepare multiple streaming messages of encoded avionics data according to each data map; and transmitting the encoded avionics data in real time to the ground station via a transmission link selected by a dynamic link manager aboard the aircraft, configured to identify and select at least one data path for the transmission link. receiving avionics data, by a processor aboard an aircraft, from a line replaceable unit aboard the aircraft, the processor being configured to operate in a monitor mode and an event mode; encoding the avionics data according to a data map, wherein the data map is one of multiple data maps received from a ground station in the monitor mode or the event mode, wherein in the monitor mode the data map identifies a first minimal data set of the avionics data, and in the event mode the data map identifies a second expanded data set of the avionics data; processing, by the processor, substantially simultaneously, more than one data set via more than one data map of the multiple data maps to substantially simultaneously prepare multiple streaming messages of encoded avionics data according to each data map; and transmitting the encoded avionics data in real time to the ground station via a transmission link selected by a dynamic link manager aboard the aircraft, configured to identify and select at least one data path for the transmission link.
Woven fabric device having a plurality of warp threads which by a plurality of weft threads are held together to form a tape-type structure having two peripheries (130, 140), wherein the mutual spacing of two weft threads in a first portion of a first periphery is dimensioned so as to be different from the mutual spacing of two weft threads in a first portion of the other periphery that lies opposite the first periphery, so as to cause a curved arrangement of the warp threads in that region of the tape-type structure that are disposed between the mutually opposite first portions (131, 141) of the respective external peripheries (130, 140), characterized in that the weft threads in different portions of the tape-type structure are disposed at dissimilar densities, so as to promote a first direction-dependent draping capability of the tape-type structure by way of reducing the density, and the warp threads in different portions of the tape-type structure are disposed at dissimilar densities, so as to promote a second direction-dependent draping capability of the tape-type structure by way of reducing the density, and wherein on account of dissimilar coatings of the warp threads and weft threads dissimilar frictional resistance values are caused in the region of the surface of the warp threads and weft threads, so as to promote a draping capability of the tape-type structure by way of reducing the frictional resistance values, or so as to reduce said draping capability by promoting the frictional resistance values.
A method for simulating interaction between a surgical tool and biological tissue, the method comprising: receiving tool input device information representative of movement of a physical representation of a portion of a simulated surgical tool; simulating, based on the tool input device information, an interaction between the simulated surgical tool and a simulated biological tissue, the simulating comprising using a plurality of simultaneously running computational threads for calculating the mechanics of the simulated biological tissue, at least some of the threads providing their calculations to one or more associated threads for use in such associated threads' calculations, wherein the plurality of threads comprise at least two threads that have different spatial resolutions, including a first spatial resolution and a second spatial resolution lower than the first resolution, wherein the first higher spatial resolution is utilised in respect of an area where a user is interacting; and displaying on a display a visual representation of the simulated interaction between the simulated surgical tool and the simulated biological tissue, the visual representation being based on the calculations of the plurality of threads. receiving tool input device information representative of movement of a physical representation of a portion of a simulated surgical tool; simulating, based on the tool input device information, an interaction between the simulated surgical tool and a simulated biological tissue, the simulating comprising using a plurality of simultaneously running computational threads for calculating the mechanics of the simulated biological tissue, at least some of the threads providing their calculations to one or more associated threads for use in such associated threads' calculations, wherein the plurality of threads comprise at least two threads that have different spatial resolutions, including a first spatial resolution and a second spatial resolution lower than the first resolution, wherein the first higher spatial resolution is utilised in respect of an area where a user is interacting; and displaying on a display a visual representation of the simulated interaction between the simulated surgical tool and the simulated biological tissue, the visual representation being based on the calculations of the plurality of threads.
A wind turbine facility adapted to deliver electrical energy to an associated power supply grid, the wind turbine facility comprising - generator means for converting mechanical energy to electrical energy, the generator means being mechanically coupled to a set of rotor blades optionally via a gearing arrangement (GEAR), - an electric power converter electrically coupled to the generator means and the associated power supply grid optionally via a grid transformer, - power dissipation/storage means being adapted to dissipate or store an amount of electrical energy from the generator means, and - control means (WTG / Conv CTRL) for determining an allowed amount of electrical energy that can be dissipated or stored in the power dissipation/storage means wherein the control means is adapted to operate the wind turbine facility in such a manner that a total amount of electrical energy generated by the wind turbine facility, in the event of a grid fault, does not exceed a sum of the allowed amount and an amount to be delivered to the power supply grid. - generator means for converting mechanical energy to electrical energy, the generator means being mechanically coupled to a set of rotor blades optionally via a gearing arrangement (GEAR), - an electric power converter electrically coupled to the generator means and the associated power supply grid optionally via a grid transformer, - power dissipation/storage means being adapted to dissipate or store an amount of electrical energy from the generator means, and - control means (WTG / Conv CTRL) for determining an allowed amount of electrical energy that can be dissipated or stored in the power dissipation/storage means