Benzopyran derivatives of the general formula wherein: D represents S or O; R 1, R 2, R 3 and R 4 are independently hydrogen, halogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, hydroxy, C 1-6 -alkoxy, C 1-6 -alkoxy-C 1-6 -alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C 1-6 -monoalkyl- or dialkylamino, sulfamoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkylsulfinyl, formyl, C 1-6 -alkylcarbonylamino, R 8 arylthio, R 8 arylsulfinyl, R 8 arylsulfonyl, C 1-6 -alkoxycarbonyl, C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, carbamoyl, carbamoylmethyl, C 1-6 -monoalkyl- or dialkylaminocarbonyl, C 1-6 -monoalkyl- or dialkylaminothiocarbonyl, ureido, C 1 - 6 -monoalkyl- or dialkylaminocarbonylamino, thioureido, C 1-6 -monoalkyl- or dialkylaminothiocarbonylamino, C 1-6 -monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C 1-6 -alkyl, acyl, R 8 aryl, R 8 aryl-C 1-6 -alkyl, R 8 aryloxy; R 5 and R 6 are each independently hydrogen, C 1-6 -alkyl or, R 5 and R 6 taken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring; R 7 is 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R 1 or R 7 is 2- or 3-thienyl optionally mono- or polysubstituted substituted by R 1 or R 7 is phenyl mono- or polysubstituted by R 1 with the exception of R 7 representing C 6 H 5; R 8 is hydrogen, halogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, hydroxy, C 1-6 -alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form. D represents S or O; R 1, R 2, R 3 and R 4 are independently hydrogen, halogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, hydroxy, C 1-6 -alkoxy, C 1-6 -alkoxy-C 1-6 -alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C 1-6 -monoalkyl- or dialkylamino, sulfamoyl, C 1-6 -alkylthio, C 1-6 -alkylsulfonyl, C 1-6 -alkylsulfinyl, formyl, C 1-6 -alkylcarbonylamino, R 8 arylthio, R 8 arylsulfinyl, R 8 arylsulfonyl, C 1-6 -alkoxycarbonyl, C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, carbamoyl, carbamoylmethyl, C 1-6 -monoalkyl- or dialkylaminocarbonyl, C 1-6 -monoalkyl- or dialkylaminothiocarbonyl, ureido, C 1 - 6 -monoalkyl- or dialkylaminocarbonylamino, thioureido, C 1-6 -monoalkyl- or dialkylaminothiocarbonylamino, C 1-6 -monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C 1-6 -alkyl, acyl, R 8 aryl, R 8 aryl-C 1-6 -alkyl, R 8 aryloxy; R 5 and R 6 are each independently hydrogen, C 1-6 -alkyl or, R 5 and R 6 taken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring; R 7 is 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R 1 or R 7 is 2- or 3-thienyl optionally mono- or polysubstituted substituted by R 1 or R 7 is phenyl mono- or polysubstituted by R 1 with the exception of R 7 representing C 6 H 5; R 8 is hydrogen, halogen, C 1-6 -alkyl, C 3-8 -cycloalkyl, hydroxy, C 1-6 -alkoxy, nitro, amino, cyano, cyanomethyl, perhalomethyl; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture or any polymorphic and tautomeric form.