An image sensing apparatus (100, 100i, 100j, 100k, 100n, 100p, 100q, 100h) comprising: a pixel array including a plurality of columns, wherein each column of the pixel array includes a plurality of pixels each including a photoelectric conversion unit; a plurality of signal lines, wherein each signal line is connected to the plurality of pixels of a column of the pixel array; a plurality of transfer blocks, wherein each transfer block is connected to the signal line of a column of the pixel array; and an output unit, which is commonly provided for the plurality of columns of the pixel array, wherein each transfer block is adapted to receive and temporarily hold a first signal, which is an optical signal, and a second signal, which is a noise signal, that are output from a readout pixel of the respective column of the pixel array to the signal line of the respective column of the pixel array at different timings of a period in which the readout pixel is being selected among the plurality of pixels of the respective column of the pixel array, characterized in that each transfer block is further adapted to output, to the output unit, a third signal on the basis of the first signal and a fourth signal on the basis of the second signal, wherein the transfer block is adapted to perform an operation of holding the first signal and the second signal and an operation of outputting the third signal and the fourth signal in parallel, each transfer block includes a first transfer unit (103S, 103Si, 103Sj, 103Sn, 103Sp, 103Sh) and a second transfer unit (103N, 103Ni, 103Nj, 103Nn, 103Np, 103Nh), the first transfer unit includes a first impedance converter (201, 401i, 801j, 1701) which has a first offset and is adapted to receive the first signal, and the first transfer unit is adapted to output, as the third signal, a difference signal between a signal, which includes the first offset, and a signal, which is obtained by superimposing the first offset on the first signal, to the output unit, the second transfer unit includes a second impedance converter (202, 402i, 802j, 1702) which has a second offset and is adapted to receive the second signal, and the second transfer unit is adapted to output, as the fourth signal, a difference signal between a signal, which includes the second offset, and a signal, which is obtained by superimposing the second offset on the second signal, to the output unit, and the output unit is adapted to generate and output an image signal indicative of a difference between the third signal and the fourth signal from a transfer block of a respective column of the pixel array for each of the plurality of columns of the pixel array. a pixel array including a plurality of columns, wherein each column of the pixel array includes a plurality of pixels each including a photoelectric conversion unit; a plurality of signal lines, wherein each signal line is connected to the plurality of pixels of a column of the pixel array; a plurality of transfer blocks, wherein each transfer block is connected to the signal line of a column of the pixel array; and an output unit, which is commonly provided for the plurality of columns of the pixel array, wherein each transfer block is adapted to receive and temporarily hold a first signal, which is an optical signal, and a second signal, which is a noise signal, that are output from a readout pixel of the respective column of the pixel array to the signal line of the respective column of the pixel array at different timings of a period in which the readout pixel is being selected among the plurality of pixels of the respective column of the pixel array, characterized in that each transfer block is further adapted to output, to the output unit, a third signal on the basis of the first signal and a fourth signal on the basis of the second signal, wherein the transfer block is adapted to perform an operation of holding the first signal and the second signal and an operation of outputting the third signal and the fourth signal in parallel, each transfer block includes a first transfer unit (103S, 103Si, 103Sj, 103Sn, 103Sp, 103Sh) and a second transfer unit (103N, 103Ni, 103Nj, 103Nn, 103Np, 103Nh), the first transfer unit includes a first impedance converter (201, 401i, 801j, 1701) which has a first offset and is adapted to receive the first signal, and the first transfer unit is adapted to output, as the third signal, a difference signal between a signal, which includes the first offset, and a signal, which is obtained by superimposing the first offset on the first signal, to the output unit, the second transfer unit includes a second impedance converter (202, 402i, 802j, 1702) which has a second offset and is adapted to receive the second signal, and the second transfer unit is adapted to output, as the fourth signal, a difference signal between a signal, which includes the second offset, and a signal, which is obtained by superimposing the second offset on the second signal, to the output unit, and the output unit is adapted to generate and output an image signal indicative of a difference between the third signal and the fourth signal from a transfer block of a respective column of the pixel array for each of the plurality of columns of the pixel array.