A compound of formula I wherein R 1 is a substituted or unsubstituted bicyclic heterocyclyl, wherein the bicyclic heterocyclyl is two connected rings containing at least one heteroatom and which is a non-aromatic bicyclic ring; R 2 is selected from H, halogen, substituted or unsubstituted C 1-4 alkyl, CF 3 substituted or unsubstituted C 1-4 alkoxy, CON 2, CN and CO 2 R; and R is selected from H and substituted or unsubstituted C 1-4 alkyl; wherein "substituted" refers to a group that is substituted with one or more groups selected from C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, halo, halOC 1-6 alkyl, haloC 3-6 cycloalkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, haloaryl, hydroxy, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, aryloxy, carboxy, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, haloaryloxy, oxo, nitro, nitroC 1-6 alkyl, nitroC 2-6 alkenyl, nitroaryl, azido, amino, C 1-6 alkylamino, C 2-6 alkenylamino, C 2-6 alkynylamino, arylamino, C 1-6 alkylacyl, C 2-6 alkenylacyl, C 2-6 alkynylacyl, arylacyl, acylamino, acyloxy, aldehydo, C 1-6 alkylsulphonyl, arylsulphonyl, C 1-6 alkylsulphonylamino, arylsulphonylamino, C 1-6 alkylsulphonyloxy, arylsulphonyloxy, C 1-6 alkylsulphenyl, arylsulphenyl, carboalkoxy, carboaryloxy, mercapto, C 1-6 alkylthio, arylthio, acylthio, and cyano, or an enantiomer thereof or a pharmaceutically acceptable salt thereof. R 1 is a substituted or unsubstituted bicyclic heterocyclyl, wherein the bicyclic heterocyclyl is two connected rings containing at least one heteroatom and which is a non-aromatic bicyclic ring; R 2 is selected from H, halogen, substituted or unsubstituted C 1-4 alkyl, CF 3 substituted or unsubstituted C 1-4 alkoxy, CON 2, CN and CO 2 R; and R is selected from H and substituted or unsubstituted C 1-4 alkyl; wherein "substituted" refers to a group that is substituted with one or more groups selected from C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, halo, halOC 1-6 alkyl, haloC 3-6 cycloalkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, haloaryl, hydroxy, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, aryloxy, carboxy, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, haloaryloxy, oxo, nitro, nitroC 1-6 alkyl, nitroC 2-6 alkenyl, nitroaryl, azido, amino, C 1-6 alkylamino, C 2-6 alkenylamino, C 2-6 alkynylamino, arylamino, C 1-6 alkylacyl, C 2-6 alkenylacyl, C 2-6 alkynylacyl, arylacyl, acylamino, acyloxy, aldehydo, C 1-6 alkylsulphonyl, arylsulphonyl, C 1-6 alkylsulphonylamino, arylsulphonylamino, C 1-6 alkylsulphonyloxy, arylsulphonyloxy, C 1-6 alkylsulphenyl, arylsulphenyl, carboalkoxy, carboaryloxy, mercapto, C 1-6 alkylthio, arylthio, acylthio, and cyano, or an enantiomer thereof or a pharmaceutically acceptable salt thereof. wherein "substituted" refers to a group that is substituted with one or more groups selected from C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, halo, halOC 1-6 alkyl, haloC 3-6 cycloalkyl, haloC 2-6 alkenyl, haloC 2-6 alkynyl, haloaryl, hydroxy, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, aryloxy, carboxy, haloC 1-6 alkoxy, haloC 2-6 alkenyloxy, haloC 2-6 alkynyloxy, haloaryloxy, oxo, nitro, nitroC 1-6 alkyl, nitroC 2-6 alkenyl, nitroaryl, azido, amino, C 1-6 alkylamino, C 2-6 alkenylamino, C 2-6 alkynylamino, arylamino, C 1-6 alkylacyl, C 2-6 alkenylacyl, C 2-6 alkynylacyl, arylacyl, acylamino, acyloxy, aldehydo, C 1-6 alkylsulphonyl, arylsulphonyl, C 1-6 alkylsulphonylamino, arylsulphonylamino, C 1-6 alkylsulphonyloxy, arylsulphonyloxy, C 1-6 alkylsulphenyl, arylsulphenyl, carboalkoxy, carboaryloxy, mercapto, C 1-6 alkylthio, arylthio, acylthio, and cyano,