mhurhangee/ep-ind-claims huggingface dataset:
A pharmaceutical combination for use in the treatment of squamous cell carcinoma of head and neck, wherein said pharmaceutical combination comprises a CDK inhibitor selected from the compounds of formula I; wherein Ar is a phenyl group, which is unsubstituted or substituted by 1, 2, or 3 identical or different substituents selected from halogen; nitro, cyano, C 1 -C 4 -alkyl, trifluoromethyl, hydroxyl and C 1 -C 4 -alkoxy; or a pharmaceutically acceptable salt or solvate thereof; and 1) one or more antineoplastic agents selected from sorafenib, lapatinib, erlotinib, and cetuximab, 2) cisplatin and 5-fluorouracil, or 3) cisplatin, 5-fluorouracil and docetaxel.
An apparatus for manufacturing a three-dimensional shaped object wherein a solidified layer is formed by irradiation of a predetermined portion of a material layer with a light beam, thereby allowing a sintering of the material in the predetermined portion or a melting and subsequent solidification of the material, the material layer being within a chamber, the apparatus comprising: the chamber; a transmission window through which the light beam is allowed to be transmitted, the window being provided in a ceiling of the chamber; a blow-out port for blowing out an inert gas toward an interior of the chamber, the port being located around the transmission window; and an annular cover member for surrounding the blow-out port, the cover member being positioned below the blow-out port and around the transmission window, wherein a gap through which the inert gas is allowed to pass is provided between the cover member and the transmission window, wherein the cover member comprises: an inner circumference wall located to provide the gap with respect to the transmission window, the wall being in a cylindrical form; and an inner flange extending inwardly from the inner circumference wall, the flange being located below the gap; characterized in that the gap is positioned immediately below an outer periphery of the transmission window. the chamber; a transmission window through which the light beam is allowed to be transmitted, the window being provided in a ceiling of the chamber; a blow-out port for blowing out an inert gas toward an interior of the chamber, the port being located around the transmission window; and an annular cover member for surrounding the blow-out port, the cover member being positioned below the blow-out port and around the transmission window, wherein a gap through which the inert gas is allowed to pass is provided between the cover member and the transmission window, wherein the cover member comprises: an inner circumference wall located to provide the gap with respect to the transmission window, the wall being in a cylindrical form; and an inner flange extending inwardly from the inner circumference wall, the flange being located below the gap; an inner circumference wall located to provide the gap with respect to the transmission window, the wall being in a cylindrical form; and an inner flange extending inwardly from the inner circumference wall, the flange being located below the gap; characterized in that the gap is positioned immediately below an outer periphery of the transmission window.
A method of detecting binding between a nucleic acid and a nucleic acid binding protein, comprising determining the degree of structural change in a nucleic acid complex having at least two nucleic acid duplex moieties, wherein the nucleic acid complex having at least two nucleic acid duplex moieties is a complex comprising the two nucleic acid duplexes bound to each other at their terminal sequences (nucleic acid duplex complex), wherein the structural change is nucleotide strand exchange between the two nucleic acid duplexes, wherein the nucleotide strand exchange between the nucleic acid duplexes is a replacement of a strand complementary to each nucleotide strand forming one nucleic acid duplex with a nucleotide strand forming the other nucleic acid duplex, and wherein the method comprises (i) contacting the nucleic acid binding protein with a nucleic acid duplex A and a nucleic acid duplex B, wherein the nucleic acid duplex A consists of two single-stranded nucleic acids (hereinafter, referred to as a "nucleic acid A1" and a "nucleic acid A2", respectively) and the nucleic acid duplex B consists of two single-stranded nucleic acids (hereinafter, referred to as a "nucleic acid B1" and a "nucleic acid B2", respectively); and (ii) determining the degree of structural change in the nucleic acid duplex complex wherein the nucleic acid A1 consists of a single-stranded nucleic acid having a first nucleotide sequence and a second nucleotide sequence; the nucleic acid A2 consists of a single-stranded nucleic acid having a sequence corresponding to the first nucleotide sequence and a third nucleotide sequence; the nucleic acid B1 consists of a single-stranded nucleic acid having a sequence corresponding to the second nucleotide sequence and a fourth nucleotide sequence; and the nucleic acid B2 consists of a single-stranded nucleic acid having a sequence corresponding to the third nucleotide sequence and a sequence corresponding to the fourth nucleotide sequence and wherein the contacting in (i) may be performed by simultaneously mixing all the nucleic acid duplex A, the nucleic acid binding protein and the nucleic acid duplex B or by mixing the nucleic acid duplex A and the nucleic acid binding protein and then adding the nucleic acid duplex B to the mixture. (i) contacting the nucleic acid binding protein with a nucleic acid duplex A and a nucleic acid duplex B, wherein the nucleic acid duplex A consists of two single-stranded nucleic acids (hereinafter, referred to as a "nucleic acid A1" and a "nucleic acid A2", respectively) and the nucleic acid duplex B consists of two single-stranded nucleic acids (hereinafter, referred to as a "nucleic acid B1" and a "nucleic acid B2", respectively); and (ii) determining the degree of structural change in the nucleic acid duplex complex
System comprising at least one cleaning machine and a product device for the product logistics of screen baskets in the preparation process of medical products, wherein the product device is a storage system for screen baskets or products that is constructed as a storage frame with spaced storage levels and can receive at least the screen baskets with products or the products on the spaced storage levels (5, 15), wherein the cleaning machine comprises a cleaning carriage having at least rotating arms as media-conveying parts or a cleaning chamber having at least rotating arms as media-conveying parts, wherein the product device included within or in conjunction with machines forms a process-connecting storage system in such a way that the process-connecting storage system can introduce externally supplied screen baskets or stored products stored in the spaced storage levels into at least one cleaning machine and receives such via the rotating arms as media-conveying parts (3, 11, 8) of the cleaning carriage (2, 20, 80, 90) or the cleaning chamber between the storage levels (5, 15) in order to move the rotating arms as media-conveying parts during the cleaning over the stored screen baskets or the stored products and to clean the products in the screen baskets or the products.
High pressure pipe of high density polyethylene material, comprising an internal lining, an intermediate reinforcement layer and an outer cover layer, wherein the high density polyethylene material of the internal lining is filled with a filling material which results in the pipe being able to transport fluids at elevated temperatures, wherein the filling material comprises a mineral, wherein the filling material comprises nanoparticles, wherein the filling material nanoparticles are platelets or are plate-shaped or are fiber-shaped or rod-shaped, and wherein the aspect ratio of the nanoparticles is at least an order of magnitude more than 1.
An apparatus for charging and housing of an unmanned vertical take-off and landing (VTOL) aircraft, the apparatus comprising: an accommodator to accommodate an aircraft; a landing platform (10, 20, 73) to be provided at a side of the apparatus, and on which an aircraft lands; a housing portion to monitor state data by housing or charging the aircraft; and a sensor (40, 55, 57, 53, 41) to assist in landing of the aircraft by allowing the aircraft to communicate with the apparatus, characterized in that the sensor includes LED/IR array lamps provided at a side of the landing platform, the LED/IR array lamps enabling an automatic landing of the aircraft, and generating a pattern during daytime and nighttime, as necessary. an accommodator to accommodate an aircraft; a landing platform (10, 20, 73) to be provided at a side of the apparatus, and on which an aircraft lands; a housing portion to monitor state data by housing or charging the aircraft; and a sensor (40, 55, 57, 53, 41) to assist in landing of the aircraft by allowing the aircraft to communicate with the apparatus, characterized in that the sensor includes LED/IR array lamps provided at a side of the landing platform, the LED/IR array lamps enabling an automatic landing of the aircraft, and generating a pattern during daytime and nighttime, as necessary.
A light-activated polypeptide comprising a) an amino acid sequence that is at least 58% identical to SEQ ID NO: 1, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of C1C2 (SEQ ID NO:78); or b) an amino acid sequence that is at least 58% identical to SEQ ID NO: 23, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of ClC2 (SEQ ID NO:78); or c) an amino acid sequence that is at least 58% identical to SEQ ID NO: 34, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of C1C2 (SEQ ID NO:80); or d) an amino acid sequence that is at least 58% identical to SEQ ID NO: 56, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of ClC2 (SEQ ID NO:81); and wherein the polypeptide functions as a light-activated anion channel. a) an amino acid sequence that is at least 58% identical to SEQ ID NO: 1, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of C1C2 (SEQ ID NO:78); or b) an amino acid sequence that is at least 58% identical to SEQ ID NO: 23, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of ClC2 (SEQ ID NO:78); or c) an amino acid sequence that is at least 58% identical to SEQ ID NO: 34, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of C1C2 (SEQ ID NO:80); or d) an amino acid sequence that is at least 58% identical to SEQ ID NO: 56, wherein the polypeptide comprises 1, 2, 3, 4, 5, 6, 7, 8, or 9 amino acid substitutions selected from T98S, E129S, E140S, E162S, V156K, H173R, T285N, V281K and N297Q, relative to the amino acid sequence of ClC2 (SEQ ID NO:81); and
Drilling-rig bearing arrangement having a main body with a suspension and having a receptacle for a drill pipe, wherein, between the main body and the receptacle for the drill pipe, there is arranged a mount for radial and axial mounting of the receptacle relative to the main body and for rotation of the drilling rig about an axis relative to main body by way of a driving means, wherein the mount has a bearing inner ring (7, 7', 7"), which consists of one part or is assembled from two parts, and a bearing outer ring (8, 8', 8"), which consists of one part or is assembled from two parts, wherein at least two raceways (9', 9", 9′′′, 10', 10", 10′′′) are formed both in the bearing inner ring (7, 7', 7'') and in the bearing outer ring (8, 8', 8''), wherein at least two rows of rolling bodies (11, 12, 13) are arranged between the raceways (9', 9", 9′′′, 10', 10'', 10′′′), wherein one of the rows of rolling bodies is tapered rollers or pendulum rollers, characterized in that the bearing inner ring or the bearing outer ring is of one-part form, and the rolling bodies (11, 12, 13) free of raceway rings (16, 17) run directly on the bearing inner ring (7, 7', 7'') and bearing outer ring (8, 8', 8"). wherein the mount has a bearing inner ring (7, 7', 7"), which consists of one part or is assembled from two parts, and a bearing outer ring (8, 8', 8"), which consists of one part or is assembled from two parts, wherein at least two raceways (9', 9", 9′′′, 10', 10", 10′′′) are formed both in the bearing inner ring (7, 7', 7'') and in the bearing outer ring (8, 8', 8''), wherein at least two rows of rolling bodies (11, 12, 13) are arranged between the raceways (9', 9", 9′′′, 10', 10'', 10′′′), wherein one of the rows of rolling bodies is tapered rollers or pendulum rollers, characterized in that the bearing inner ring or the bearing outer ring is of one-part form, and the rolling bodies (11, 12, 13) free of raceway rings (16, 17) run directly on the bearing inner ring (7, 7', 7'') and bearing outer ring (8, 8', 8").
A method for preventing collision of tags in a radio frequency identification (RFID) system, comprising: a reader beginning to inventory tags and waiting for replies of the tags; if replies of the tags collide, splitting the tags into two subsets, the tags in one of the subsets replying to the reader, and when inventory of the tags in the subset is completed, the tags in the other subset beginning to reply; if collision occurs during the replying by the tags in the subset, the subset splitting again, and so forth, till inventory of all the tags is completed; and characterized by that, during splitting of the tags in the subsets, performing simultaneous splitting of a plurality of branches of tags at least once. a reader beginning to inventory tags and waiting for replies of the tags; if replies of the tags collide, splitting the tags into two subsets, the tags in one of the subsets replying to the reader, and when inventory of the tags in the subset is completed, the tags in the other subset beginning to reply; if collision occurs during the replying by the tags in the subset, the subset splitting again, and so forth, till inventory of all the tags is completed; and
A test pattern creation method employing a printing apparatus including a transparent ink print head that ejects a transparent ink, a first print head that ejects a first colored ink, and a second print head that ejects a second colored ink, the creation method comprising: forming a base-coat on a print medium using the first colored ink; and creating, as a plurality of ruled lines to measure impact displacement of the transparent ink, a first ruled line set formed by layering the transparent ink over the base-coat, and a second ruled line set formed outside a region corresponding to the base-coat using the second colored ink; characterized in that the method further comprises: forming a crossmark indicating a boundary between the first ruled line set and the second ruled line set. forming a base-coat on a print medium using the first colored ink; and creating, as a plurality of ruled lines to measure impact displacement of the transparent ink, a first ruled line set formed by layering the transparent ink over the base-coat, and a second ruled line set formed outside a region corresponding to the base-coat using the second colored ink; characterized in that the method further comprises: forming a crossmark indicating a boundary between the first ruled line set and the second ruled line set.
Aircraft air conditioning system with: - a mixer, - a recirculation air line connected to the mixer, and adapted to be flown through with recirculation air taken from an aircraft cabin, in order to supply recirculation air to the mixer, - an ambient air line adapted to be flown through with ambient air and being connected to the mixer, in order to supply ambient air to the mixer, - at least one ambient air compressor (42, 58) arranged in the ambient air line for compressing the ambient air flowing through the ambient air line and - a refrigerating apparatus, which comprises a refrigerant circuit adapted to be flown through with a refrigerant as well as a refrigerant compressor arranged in the refrigerant circuit, wherein the refrigerant circuit is coupled thermally to the ambient air line, in order to transfer heat from the ambient air flowing through the ambient air line to the refrigerant circulating in the refrigerant circuit before the ambient air is supplied to the mixer, characterised by - a cabin exhaust air line, and - a cabin exhaust air turbine, which is connected to the cabin exhaust air line and is coupled to the at least one ambient air compressor (42, 58) arranged in the ambient air line and is configured to expand the cabin exhaust air flowing through the cabin exhaust air line and to drive the at least one ambient air compressor (42, 58) arranged in the ambient air line, wherein the refrigerating apparatus further comprises an evaporator, which thermally couples the refrigerant circuit and the recirculation air line, in order to transfer heat from the recirculation air flowing through the recirculation air line to the refrigerant flowing through the refrigerant circuit. - a mixer, - a recirculation air line connected to the mixer, and adapted to be flown through with recirculation air taken from an aircraft cabin, in order to supply recirculation air to the mixer, - an ambient air line adapted to be flown through with ambient air and being connected to the mixer, in order to supply ambient air to the mixer, - at least one ambient air compressor (42, 58) arranged in the ambient air line for compressing the ambient air flowing through the ambient air line and - a refrigerating apparatus, which comprises a refrigerant circuit adapted to be flown through with a refrigerant as well as a refrigerant compressor arranged in the refrigerant circuit, wherein the refrigerant circuit is coupled thermally to the ambient air line, in order to transfer heat from the ambient air flowing through the ambient air line to the refrigerant circulating in the refrigerant circuit before the ambient air is supplied to the mixer, characterised by - a cabin exhaust air line, and - a cabin exhaust air turbine, which is connected to the cabin exhaust air line and is coupled to the at least one ambient air compressor (42, 58) arranged in the ambient air line and is configured to expand the cabin exhaust air flowing through the cabin exhaust air line and to drive the at least one ambient air compressor (42, 58) arranged in the ambient air line,
Device for cleaning and sterilizing in a treatment container, comprising a product discharge connection and a beta port arranged on the discharge connection, and a process line for discharging process media, comprising a process attachment which has a port opening system and is connected to the discharge connection and to the process line during treatment, such that the process media flow through the open port and clean and sterilize said port, characterized in that the treatment container is rigidly connected to a carriage and is rotatably arranged on the carriage.
An engine mount for securing an engine in a motor vehicle, having a base body, wherein the base body includes an attachment region for supporting a bearing portion on the side toward the vehicle and includes a flanging region for locating the engine on the engine mount, wherein the flanging region is formed by a rubber element located on the base body and by an inlaid element provided in the rubber element, and that the inlaid element is cast or vulcanized into the rubber element, wherein the inlaid element has an abutment portion for contact with the engine, wherein the inlaid element has a securing portion for securing the engine, characterized in that the abutment portion is embodied in flangelike fashion, extends transversely to the longitudinal extent of the inlaid element, and protrudes from the inlaid element in the transverse direction.
System for aligning a medical device with respect to a location on a patient with an insertion axis extending through said location and a predetermined target location in said patient, wherein the system comprises: - a base arranged for connecting the system to the surroundings, for instance a patient support of a scanner; - an alignment device comprising a stationary part and an axial guide, wherein the axial guide is arranged for guiding the medical device along a guiding axis, wherein the alignment device is arranged for rotating the axial guide about a remote centre of rotation while the guiding axis extends through said remote centre of rotation; - an arm connecting the base and the stationary part of the alignment device, wherein the arm comprises locking means which are moveable between a locked position wherein the position of the alignment device with respect to the base is fixed and a moveable position wherein the alignment device is moveable with respect to the base for positioning the remote centre of rotation on the location on the patient, wherein the system comprises at least one fiducial marker for determining the position and orientation of the stationary part of the alignment device by an imaging technique, characterised in that the alignment device is arranged such that the position of the remote centre of rotation with respect to the stationary part is fixed and further comprising a controller to control the the alignment device to rotate the axial guide about the remote centre of rotation with respect to the stationary part for aligning the guiding axis with the insertion axis using the determined position and orientation of said stationary part as a reference. - a base arranged for connecting the system to the surroundings, for instance a patient support of a scanner; - an alignment device comprising a stationary part and an axial guide, wherein the axial guide is arranged for guiding the medical device along a guiding axis, wherein the alignment device is arranged for rotating the axial guide about a remote centre of rotation while the guiding axis extends through said remote centre of rotation; - an arm connecting the base and the stationary part of the alignment device,