mhurhangee/ep-ind-claims huggingface dataset:
A vacuum pump, in particular a turbomolecular pump, having at least one pump stage which comprises at least one rotor which is rotatably supported by means of at least one bearing device; having a first sensor device which is arranged adjacent to the bearing device and by which a temperature of the bearing device can be determined; and having a second sensor device which is arranged spaced apart from the bearing device and by which a temperature of the vacuum pump, in particular a temperature of a housing of the vacuum pump, can be determined, wherein a control device is provided which is configured and adapted to compare the temperature of the bearing device and the temperature of the vacuum pump with one another and to determine an operating state of the bearing device on the basis of the comparison, characterized in that the vacuum pump comprises an active cooling device which is at least provided for a cooling of a component of the vacuum pump whose temperature can be determined by the second sensor device.
A pull-out guide for drawers and the like comprising a fixed guide part fastenable to the body of a piece of furniture, a movable guide part fixable to a drawer or the like, an intermediate guide part between said fixed guide part and said movable guide part, at least one first sliding carriage interposed between the fixed guide part and the intermediate guide part, at least one second carriage interposed between the movable guide part and the intermediate guide part, and means of synchronizing the pull-out guide, said synchronization means comprising at least one synchronization element arranged on said intermediate guide part and contoured to functionally connect said fixed guide part and said movable guide part to each other during the pull-out or retraction movement of the pull-out guide, said at least one synchronization element interacting with respective engagement sections (17, 18) on said fixed guide part and said movable guide part, said engagement sections (17, 18) extending opposite to each other at least along a longitudinal portion of said fixed and movable guide parts (11, 12), wherein the movable guide part extends according to a longitudinal axis, characterized in that the engagement section provided on said movable guide part extends according to an axis that is inclined with respect to the longitudinal axis of the movable guide part in a vertical plane.
Pressure swing adsorption method for producing a gaseous stream enriched with a compound X from a gaseous input stream, using at least two adsorbers, each adsorber being subjected to a pressure cycle having a high pressure and a low pressure and comprising the following consecutive steps: a) adsorption at the high pressure of the cycle with production of the gaseous stream enriched with the compound X b) depressurisation down to the low pressure of the cycle c) elution at the low pressure by means of an elution gas d) repressurisation up to the high pressure characterised in that: - the elution gas comprises a fraction of a gaseous stream from the depressurisation of an adsorber and a fraction of the gaseous stream enriched with the compound X, - said fraction of the gaseous stream enriched with the compound X can be adjusted using adjustment means, and - the pressure cycle has a phase time corresponding to the duration of a pressure cycle divided by the number of adsorbers and the fraction of the gaseous stream enriched with the compound X is determined in accordance with the phase. a) adsorption at the high pressure of the cycle with production of the gaseous stream enriched with the compound X b) depressurisation down to the low pressure of the cycle c) elution at the low pressure by means of an elution gas d) repressurisation up to the high pressure - the elution gas comprises a fraction of a gaseous stream from the depressurisation of an adsorber and a fraction of the gaseous stream enriched with the compound X, - said fraction of the gaseous stream enriched with the compound X can be adjusted using adjustment means, and - the pressure cycle has a phase time corresponding to the duration of a pressure cycle divided by the number of adsorbers and the fraction of the gaseous stream enriched with the compound X is determined in accordance with the phase.
A heat-resistant molybdenum alloy characterized by comprising: a first phase containing Mo as a main component; and a second phase comprising a Mo-Si-B-based intermetallic compound particle phase, wherein the Si content is 0.10 mass% or more and 0.50 mass% or less, the B content is 0.08 mass% or more and 0.41 mass% or less, and the balance is the Mo and an inevitable impurity. a first phase containing Mo as a main component; and a second phase comprising a Mo-Si-B-based intermetallic compound particle phase, wherein the Si content is 0.10 mass% or more and 0.50 mass% or less, the B content is 0.08 mass% or more and 0.41 mass% or less, and the balance is the Mo and an inevitable impurity.
A motor control device configured to drive-control a motor based on PWM signals and having input ports for receiving at least two emergency stop signals, and the motor control device comprising: a large scale integrated circuit, LSI, for generating the PWM signals; a PWM signal transmission circuit for transmitting the PWM signals generated by the LSI; a drive circuit for generating inverter drive signals based on the PWM signals transmitted from the PWM signal transmission circuit; and an inverter circuit having a P-side power switching device and an N-side power switching device, the inverter circuit arranged to generate motor drive signals based on the inverter drive signals, the motor drive signals to be applied to individual phase windings of the motor, wherein the drive circuit includes a P-side drive circuit (43p, 47p) for driving the P-side power switching device and an N-side drive circuit (43n, 47n) for driving the N-side power switching device; one of the emergency stop signals is an input signal of the P-side drive circuit (43p, 47p) and the PWM signal transmission circuit; another of the emergency stop signals is an input signal of the N-side drive circuit (43n, 47n) and the PWM signal transmission circuit; the PWM signal transmission circuit is arranged to stop transmitting the PWM signals in response to receipt of any of the emergency stop signals; and the drive circuit is arranged to stop outputting the inverter drive signals in response to the receipt of any of the emergency stop signals. a large scale integrated circuit, LSI, for generating the PWM signals; a PWM signal transmission circuit for transmitting the PWM signals generated by the LSI; a drive circuit for generating inverter drive signals based on the PWM signals transmitted from the PWM signal transmission circuit; and an inverter circuit having a P-side power switching device and an N-side power switching device, the inverter circuit arranged to generate motor drive signals based on the inverter drive signals, the motor drive signals to be applied to individual phase windings of the motor, wherein the drive circuit includes a P-side drive circuit (43p, 47p) for driving the P-side power switching device and an N-side drive circuit (43n, 47n) for driving the N-side power switching device; one of the emergency stop signals is an input signal of the P-side drive circuit (43p, 47p) and the PWM signal transmission circuit; another of the emergency stop signals is an input signal of the N-side drive circuit (43n, 47n) and the PWM signal transmission circuit; the PWM signal transmission circuit is arranged to stop transmitting the PWM signals in response to receipt of any of the emergency stop signals; and the drive circuit is arranged to stop outputting the inverter drive signals in response to the receipt of any of the emergency stop signals.
A method for preparing Cangrelor tetrasodium salt, comprising the following steps: step, reacting a compound C with phosphorus oxychloride in an organic solvent to obtain a reaction solution containing a compound B; step, reacting the reaction solution containing the compound B obtained in step with clodronic acid or a monosalt thereof in the presence of an acid-binding agent, and then with sodium bicarbonate to obtain a reaction solution containing Cangrelor tetrasodium salt; and step, obtaining Cangrelor tetrasodium salt from the reaction solution containing Cangrelor tetrasodium salt obtained in step; preferably, separating and purifying the reaction solution containing Cangrelor tetrasodium salt obtained in step by column chromatography, eluting with an eluent, collecting the eluate of Cangrelor tetrasodium salt with a HPLC purity ≥99.5% and lyophilizing to obtain Cangrelor tetrasodium salt; more preferably, the column chromatography is C18 silica gel column chromatography; most preferably, separating and purifying the reaction solution containing Cangrelor tetrasodium salt obtained in step by column chromatography once, eluting with an eluent to obtain an eluate of Cangrelor tetrasodium salt with a HPLC purity ≥99.5%, and lyophilizing to obtain Cangrelor tetrasodium salt. step, reacting a compound C with phosphorus oxychloride in an organic solvent to obtain a reaction solution containing a compound B; step, reacting the reaction solution containing the compound B obtained in step with clodronic acid or a monosalt thereof in the presence of an acid-binding agent, and then with sodium bicarbonate to obtain a reaction solution containing Cangrelor tetrasodium salt; and step, obtaining Cangrelor tetrasodium salt from the reaction solution containing Cangrelor tetrasodium salt obtained in step; preferably, separating and purifying the reaction solution containing Cangrelor tetrasodium salt obtained in step by column chromatography, eluting with an eluent, collecting the eluate of Cangrelor tetrasodium salt with a HPLC purity ≥99.5% and lyophilizing to obtain Cangrelor tetrasodium salt; more preferably, the column chromatography is C18 silica gel column chromatography; most preferably, separating and purifying the reaction solution containing Cangrelor tetrasodium salt obtained in step by column chromatography once, eluting with an eluent to obtain an eluate of Cangrelor tetrasodium salt with a HPLC purity ≥99.5%, and lyophilizing to obtain Cangrelor tetrasodium salt.
An image reading apparatus, comprising: - an illuminating optical system (4, 5) having a plurality of light sources arranged in a line along a scanning direction of a document, and a light guide member for causing rays of light from the plurality of light sources to pass therethrough; - a document conveying control system (2, 3, 9) for conveying the document in a subscanning direction perpendicular to the scanning direction, and for causing the document to pass through a document reading position which is set up near a light emergence surface of the light guide member from which the rays of light from the plurality of light sources are emitted; - an image reading optical system (6, 7, 8) comprising a plurality of image formation optical systems and a plurality of light receiving elements which are aligned in the scanning direction, for reading light passing through the document at the document reading position; characterized by either a convex or concave cylindrical lens array having a plurality of ridge lines or trough lines, respectively, each running along the subscanning direction, the plurality of ridge lines or trough lines being aligned in the scanning direction, being formed in the light emitting surface of the light guide member from which the rays of light from the plurality of light sources are emitted, wherein the indents of the convex cylindrical lens array are defined between the ridge lines, or the protrusions of the concave cylindrical lens array are defined between the trough lines, and extend along the subscanning direction. - an illuminating optical system (4, 5) having a plurality of light sources arranged in a line along a scanning direction of a document, and a light guide member for causing rays of light from the plurality of light sources to pass therethrough; - a document conveying control system (2, 3, 9) for conveying the document in a subscanning direction perpendicular to the scanning direction, and for causing the document to pass through a document reading position which is set up near a light emergence surface of the light guide member from which the rays of light from the plurality of light sources are emitted; - an image reading optical system (6, 7, 8) comprising a plurality of image formation optical systems and a plurality of light receiving elements which are aligned in the scanning direction, for reading light passing through the document at the document reading position;
A gas turbine engine comprising: a turbine driving a gear reduction, and said gear reduction driving a fan drive shaft assembly to, in turn, drive a fan rotor at a reduced speed relative to said turbine; a generator to generate current upon rotation of said fan drive assembly; and said generator supplying electric current to an electric motor driven pump (130;208), said electric motor driven pump (130;208) delivering lubricant to components within said gear reduction, wherein said fan drive assembly includes a shell which is driven to rotate with a ring gear in said gear reduction, and said shell having an inner surface, and a chamber being defined between said shell inner surface and said gear reduction, characterised in that: said generator is positioned within said chamber. a turbine driving a gear reduction, and said gear reduction driving a fan drive shaft assembly to, in turn, drive a fan rotor at a reduced speed relative to said turbine; a generator to generate current upon rotation of said fan drive assembly; and said generator supplying electric current to an electric motor driven pump (130;208), said electric motor driven pump (130;208) delivering lubricant to components within said gear reduction, wherein said fan drive assembly includes a shell which is driven to rotate with a ring gear in said gear reduction, and said shell having an inner surface, and a chamber being defined between said shell inner surface and said gear reduction, characterised in that: said generator is positioned within said chamber.
A laundry drying machine comprising a laundry chamber suitable for receiving the laundry to be dried, an air stream circuit for circulating an air stream through said laundry chamber and a heat pump system (20; 120; 220; 320; 420) comprising: - a first heat exchanger for heating up said air stream conveyable into said laundry chamber; - a second heat exchanger for dehumidifying the moist air of said air stream coming from said laundry chamber; - a compressor comprising an outlet connectable to said first heat exchanger and an inlet connectable to said second heat exchanger; - an expansion device comprising an outlet connectable to said second heat exchanger and an inlet connectable to said first heat exchanger; an auxiliary heat exchanger comprising a portion (31; 41; 51; 61; 150) of said heat pump system (20; 120; 220; 320; 420) arranged downstream said expansion device outlet and upstream said compressor inlet and characterised in that it further comprises a cooling member (57; 77) associated to an electric and/or an electronic device which generates heat of said machine, so that said portion (31; 41; 51; 61; 150) of said heat pump system (20; 120; 220; 320; 420) is subjected to a heat exchange with heat generated by said electric and/or electronic device of said machine. - a first heat exchanger for heating up said air stream conveyable into said laundry chamber; - a second heat exchanger for dehumidifying the moist air of said air stream coming from said laundry chamber; - a compressor comprising an outlet connectable to said first heat exchanger and an inlet connectable to said second heat exchanger; - an expansion device comprising an outlet connectable to said second heat exchanger and an inlet connectable to said first heat exchanger; an auxiliary heat exchanger comprising a portion (31; 41; 51; 61; 150) of said heat pump system (20; 120; 220; 320; 420) arranged downstream said expansion device outlet and upstream said compressor inlet and characterised in that it further comprises a cooling member (57; 77) associated to an electric and/or an electronic device which generates heat of said machine, so that said portion (31; 41; 51; 61; 150) of said heat pump system (20; 120; 220; 320; 420) is subjected to a heat exchange with heat generated by said electric and/or electronic device of said machine.
A support apparatus (2, 18, 20, 22) comprising: a body adapted to support a body part of a user; and at least one stiffness adjusting member (6, 24, 26, 28) adapted to be removably mounted to said body to adjust the stiffness of the apparatus (2, 18, 20, 22); wherein said body comprises a plurality of first engaging members and at least one said stiffness adjusting member (6, 24, 26, 28) comprises a plurality of second engaging members for removably engaging at least two of said first engaging members to mount the stiffness adjusting member (6, 24, 26, 28) to the body; characterised in that said first engaging members are arranged to allow re-engagement of said stiffness adjusting member (6, 24, 26, 28) to another location on said body and/or engagement of a plurality of said stiffness adjusting members (6, 24, 26, 28) at different respective locations on said body, wherein a number of said first engaging members provided on said body is greater than a number of said second engaging members provided on said stiffness adjusting member (6, 24, 26, 28). a body adapted to support a body part of a user; and at least one stiffness adjusting member (6, 24, 26, 28) adapted to be removably mounted to said body to adjust the stiffness of the apparatus (2, 18, 20, 22); wherein said body comprises a plurality of first engaging members and at least one said stiffness adjusting member (6, 24, 26, 28) comprises a plurality of second engaging members for removably engaging at least two of said first engaging members to mount the stiffness adjusting member (6, 24, 26, 28) to the body; characterised in that said first engaging members are arranged to allow re-engagement of said stiffness adjusting member (6, 24, 26, 28) to another location on said body and/or engagement of a plurality of said stiffness adjusting members (6, 24, 26, 28) at different respective locations on said body, wherein a number of said first engaging members provided on said body is greater than a number of said second engaging members provided on said stiffness adjusting member (6, 24, 26, 28).
A secure USB signal extension apparatus comprising: a first format converter and booster device disposed within a secure facility, the first format converter and booster device being configured to bi-directionally convert and multiplex/de-multiplex between USB signals and a second signaling protocol; and a second format converter and booster device disposed outside the secure facility, the second format converter and booster device being configured to bi-directionally convert and multiplex/de-multiplex between USB signals and the second signaling protocol; each of the format converter and booster devices comprising: a plurality of USB ports; a network port; a multiplexer/de-multiplexer circuit for encoding signals from the plurality of USB ports to the network port, and for decoding signals from the network port to the plurality of USB ports, and a network cable connecting through a boundary of the secure facility the respective network ports of the first and second format converter and booster devices; wherein the first format converter and booster device and the second format converter and booster device are configured to boost signals sent to the second format converter and booster device and first format converter and booster device, respectively. a first format converter and booster device disposed within a secure facility, the first format converter and booster device being configured to bi-directionally convert and multiplex/de-multiplex between USB signals and a second signaling protocol; and a second format converter and booster device disposed outside the secure facility, the second format converter and booster device being configured to bi-directionally convert and multiplex/de-multiplex between USB signals and the second signaling protocol; each of the format converter and booster devices comprising: a plurality of USB ports; a network port; a multiplexer/de-multiplexer circuit for encoding signals from the plurality of USB ports to the network port, and for decoding signals from the network port to the plurality of USB ports, and a network cable connecting through a boundary of the secure facility the respective network ports of the first and second format converter and booster devices; wherein the first format converter and booster device and the second format converter and booster device are configured to boost signals sent to the second format converter and booster device and first format converter and booster device, respectively. a plurality of USB ports; a network port; a multiplexer/de-multiplexer circuit for encoding signals from the plurality of USB ports to the network port, and for decoding signals from the network port to the plurality of USB ports, and a network cable connecting through a boundary of the secure facility the respective network ports of the first and second format converter and booster devices; wherein the first format converter and booster device and the second format converter and booster device are configured to boost signals sent to the second format converter and booster device and first format converter and booster device, respectively.
A method comprising (a) contacting a fusion protein comprising a polypeptide and a split intein N-fragment comprising a sequence selected from the group consisting of SEQ ID NO: 1-19, or a variant thereof, wherein the variant consists of a sequence selected from the group consisting of SEQ ID NO: 21-38 and 761 and a split intein C-fragment comprising a sequence selected from the group consisting of SEQ ID NO: 57-74 and 708 or a variant thereof, wherein the variant consists of a sequence selected from the group consisting of SEQ ID NO: 75-128, 707 and 709-711, wherein contacting is performed under conditions that permit binding of the split intein N-fragment to the split intein C-fragment to form an intein intermediate; and (b) contacting the intein intermediate with a nucleophile to form a conjugate of the protein and the nucleophile. (a) contacting a fusion protein comprising a polypeptide and a split intein N-fragment comprising a sequence selected from the group consisting of SEQ ID NO: 1-19, or a variant thereof, wherein the variant consists of a sequence selected from the group consisting of SEQ ID NO: 21-38 and 761 and a split intein C-fragment comprising a sequence selected from the group consisting of SEQ ID NO: 57-74 and 708 or a variant thereof, wherein the variant consists of a sequence selected from the group consisting of SEQ ID NO: 75-128, 707 and 709-711, wherein contacting is performed under conditions that permit binding of the split intein N-fragment to the split intein C-fragment to form an intein intermediate; and (b) contacting the intein intermediate with a nucleophile to form a conjugate of the protein and the nucleophile.
Compound having the following formula: which may be in base form or in the form of a hydrate or a solvate, for its use as a medicament in the treatment of cancer in patients with hepatic impairment where the administered standard dose of 25 mg/m 2 of the compound is reduced, wherein the hepatic impairment is moderate, wherein the compound is administered at a reduced dose of 15 mg/m 2, wherein the cancer to be treated is a castration resistant or hormone-refractory metastatic prostate cancer.