An apparatus for sample processing comprising: a transducer that generates sonic or ultrasonic energy of a selected frequency, the transducer further comprising an interface having an at least partially tapered conical surface through which the sonic or ultrasonic energy is propagated; and a sample collector having a sidewall at least partially complementary to the interface of the transducer that couples with the interface and receives at least a portion of the sonic or ultrasonic energy generated by the transducer and propagates the sonic or ultrasonic energy into an interior compartment of the sample collector inducing sample cavitation that disrupts or lyses materials disposed within the sample collector; wherein the transducer further comprises a recessed portion in which the interface is disposed, the recessed portion of the transducer dimensioned to receive at least a portion of the sample collector positioning the interface and sidewall in close proximity to thereby propagate the energy generated by the transducer into the interior compartment of the sample collector; wherein the sample collector comprises an inlet portion and an outlet portion, the inlet portion dimensioned to receive a sample to bo positioned in the interior compartment of the sample collector, the outlet portion dimensioned to dispense at least a portion of the disrupted or lysed material generated by the propagated energy while the interface and sidewall remain in close proximity; and wherein the sample collector further comprises one or more filters that separate the sample from at least a portion of the disrupted or lysed materials allowing selective passage of the materials through the outlet portion of the sample collector. a transducer that generates sonic or ultrasonic energy of a selected frequency, the transducer further comprising an interface having an at least partially tapered conical surface through which the sonic or ultrasonic energy is propagated; and a sample collector having a sidewall at least partially complementary to the interface of the transducer that couples with the interface and receives at least a portion of the sonic or ultrasonic energy generated by the transducer and propagates the sonic or ultrasonic energy into an interior compartment of the sample collector inducing sample cavitation that disrupts or lyses materials disposed within the sample collector; wherein the transducer further comprises a recessed portion in which the interface is disposed, the recessed portion of the transducer dimensioned to receive at least a portion of the sample collector positioning the interface and sidewall in close proximity to thereby propagate the energy generated by the transducer into the interior compartment of the sample collector; wherein the sample collector comprises an inlet portion and an outlet portion, the inlet portion dimensioned to receive a sample to bo positioned in the interior compartment of the sample collector, the outlet portion dimensioned to dispense at least a portion of the disrupted or lysed material generated by the propagated energy while the interface and sidewall remain in close proximity; and wherein the sample collector further comprises one or more filters that separate the sample from at least a portion of the disrupted or lysed materials allowing selective passage of the materials through the outlet portion of the sample collector.