An amide derivative of formula I-a, I-b or I-c wherein independently from each other R 1 denotes Ar A or Hetar A; R 2 denotes Ar B or Hetar B; R 3 denotes C 1-6 -aliphatic or -O-C 1-6 -aliphatic; R 4 denotes H, D, C 1-6 -aliphatic or -O-C 1-6 -aliphatic; R 6 denotes H, D, C 1-6 -aliphatic, -O-C 1-6 -aliphatic or halogen; R 6 denotes Hetar C or -CH 2 -Hetar C; Ar A is a mono- or biaryl with 5, 6, 7, 8, 9, 10, 11 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R A1, R A2, R A3, R A4 and/or R A5 which may be the same or different; Ar B is a mono- or biaryl with 5, 6, 7, 8, 9, 10, 11 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R B1, R B2, R B3, R B4 and/or R B5 which may be the same or different; Hetar A is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R A1, R A2, R A3, R A4 and/or R A5 which may be the same or different; Hetar B is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R B1, R B2, R B3, R B4 and/or R B5 which may be the same or different; Hetar C is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R C1, R C2, R C3, R C4 and/or R C5 which may be the same or different; R A1, R A2, R A3, R A4, R A5, R B1, R B2, R B3, R B4, R B5, R C1, R C2, R C3, R C4, R C5 are independently from each other H, D, halogen, C 1-6 -aliphatic, -O-C 1-6 -aliphatic; halogen denotes F, Cl, Br or I; or any N-oxide, solvate, tautomer or stereoisomer thereof and/or any pharmaceutically acceptable salt of each of the foregoing, including mixtures thereof in all ratios. wherein independently from each other R 1 denotes Ar A or Hetar A; R 2 denotes Ar B or Hetar B; R 3 denotes C 1-6 -aliphatic or -O-C 1-6 -aliphatic; R 4 denotes H, D, C 1-6 -aliphatic or -O-C 1-6 -aliphatic; R 6 denotes H, D, C 1-6 -aliphatic, -O-C 1-6 -aliphatic or halogen; R 6 denotes Hetar C or -CH 2 -Hetar C; Ar A is a mono- or biaryl with 5, 6, 7, 8, 9, 10, 11 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R A1, R A2, R A3, R A4 and/or R A5 which may be the same or different; Ar B is a mono- or biaryl with 5, 6, 7, 8, 9, 10, 11 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R B1, R B2, R B3, R B4 and/or R B5 which may be the same or different; Hetar A is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R A1, R A2, R A3, R A4 and/or R A5 which may be the same or different; Hetar B is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R B1, R B2, R B3, R B4 and/or R B5 which may be the same or different; Hetar C is a mono- or bicyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R C1, R C2, R C3, R C4 and/or R C5 which may be the same or different; R A1, R A2, R A3, R A4, R A5, R B1, R B2, R B3, R B4, R B5, R C1, R C2, R C3, R C4, R C5 are independently from each other H, D, halogen, C 1-6 -aliphatic, -O-C 1-6 -aliphatic; halogen denotes F, Cl, Br or I; or any N-oxide, solvate, tautomer or stereoisomer thereof and/or any pharmaceutically acceptable salt of each of the foregoing, including mixtures thereof in all ratios.