A machine for pharmaceutical or biotechnological processes, comprising: - a structure which has an upper part, a lower part and, between the upper part and lower part, walls (13, 14, 15, 16) comprising a first wall and a second wall opposite the first wall and the upper part, the lower part and the walls (13, 14, 15, 16) delimiting a chamber; - movement means for moving materials and/or instruments, which are configured to move the materials and/or the instruments in an operating space internally of the chamber; - ventilation means which comprise at least a fluid injection mouth (21a, 21b) internally of the chamber superiorly of the operating space, at least a fluid extraction mouth (25a, 25b) of fluid from the chamber inferiorly of the operating space and at least a fluid treatment unit suitable for pharmaceutical or biotechnological processes upstream of the at least an injection mouth (21a, 21b), with the ventilation means moving a fluid from the at least an injection mouth (21a, 21b) to the at least an extraction mouth (25a, 25b); wherein the first wall comprises a first part, a second part and an inclined part which extends between the first part and the second part, inferiorly of the second part and superiorly of the first part, and which is contiguous with the first part and with the second part so as to confine the chamber; - the operating space extends, at least in part, above the inclined part and/or in a volume arranged superiorly of the first part and in front of the inclined part; - the inclined part is inclined with respect to a horizontal plane so that the horizontal section of the chamber crossed by the fluid reduces while descending towards the first part, the machine being characterised in that the structure is configured so that the horizontal section of the chamber is constant, or substantially constant, or diminishes descending from the at least an injection mouth (21a, 21b) to the at least an extraction mouth (25a, 25b); and in that the second part is distanced from the first part according to a horizontal direction. - a structure which has an upper part, a lower part and, between the upper part and lower part, walls (13, 14, 15, 16) comprising a first wall and a second wall opposite the first wall and the upper part, the lower part and the walls (13, 14, 15, 16) delimiting a chamber; - movement means for moving materials and/or instruments, which are configured to move the materials and/or the instruments in an operating space internally of the chamber; - ventilation means which comprise at least a fluid injection mouth (21a, 21b) internally of the chamber superiorly of the operating space, at least a fluid extraction mouth (25a, 25b) of fluid from the chamber inferiorly of the operating space and at least a fluid treatment unit suitable for pharmaceutical or biotechnological processes upstream of the at least an injection mouth (21a, 21b), with the ventilation means moving a fluid from the at least an injection mouth (21a, 21b) to the at least an extraction mouth (25a, 25b); the first wall comprises a first part, a second part and an inclined part which extends between the first part and the second part, inferiorly of the second part and superiorly of the first part, and which is contiguous with the first part and with the second part so as to confine the chamber; - the operating space extends, at least in part, above the inclined part and/or in a volume arranged superiorly of the first part and in front of the inclined part; - the inclined part is inclined with respect to a horizontal plane so that the horizontal section of the chamber crossed by the fluid reduces while descending towards the first part, - the operating space extends, at least in part, above the inclined part and/or in a volume arranged superiorly of the first part and in front of the inclined part; - the inclined part is inclined with respect to a horizontal plane so that the horizontal section of the chamber crossed by the fluid reduces while descending towards the first part, the machine being characterised in that the structure is configured so that the horizontal section of the chamber is constant, or substantially constant, or diminishes descending from the at least an injection mouth (21a, 21b) to the at least an extraction mouth (25a, 25b); and in that the second part is distanced from the first part according to a horizontal direction.