A reduced-pressure treatment system for treating a tissue site on a patient, the system comprising: a manifold member for placing proximate the tissue site; an over-drape for providing a fluid seal over the manifold member and the patient; a reduced-pressure subsystem (126, 200) for delivering reduced pressure to the over-drape; and wherein the reduced-pressure subsystem (126, 200) comprises: a reservoir having an interior space operable to contain fluids; a reduced-pressure delivery conduit in fluid communication with the interior space for delivering reduced pressure to the over-drape; a source conduit in fluid communication with the interior space; a pressure sensor conduit in fluid communication with the interior space; a pressure sensor in fluid communication with the pressure sensor conduit; a reduced-pressure source in fluid communication with the source conduit and operable to deliver reduced pressure to the source conduit; a power sensor that produces supply data indicative of reduced pressure made available to the source conduit; and a reduced-pressure control unit associated with the pressure sensor and reduced-pressure source, the reduced-pressure control unit operable to receive pressure data from the pressure sensor and operable to receive the supply data from the power sensor and to determine when a reservoir-full/blockage condition exists. a manifold member for placing proximate the tissue site; an over-drape for providing a fluid seal over the manifold member and the patient; a reduced-pressure subsystem (126, 200) for delivering reduced pressure to the over-drape; and wherein the reduced-pressure subsystem (126, 200) comprises: a reservoir having an interior space operable to contain fluids; a reduced-pressure delivery conduit in fluid communication with the interior space for delivering reduced pressure to the over-drape; a source conduit in fluid communication with the interior space; a pressure sensor conduit in fluid communication with the interior space; a pressure sensor in fluid communication with the pressure sensor conduit; a reduced-pressure source in fluid communication with the source conduit and operable to deliver reduced pressure to the source conduit; a power sensor that produces supply data indicative of reduced pressure made available to the source conduit; and a reduced-pressure control unit associated with the pressure sensor and reduced-pressure source, the reduced-pressure control unit operable to receive pressure data from the pressure sensor and operable to receive the supply data from the power sensor and to determine when a reservoir-full/blockage condition exists. a reservoir having an interior space operable to contain fluids; a reduced-pressure delivery conduit in fluid communication with the interior space for delivering reduced pressure to the over-drape; a source conduit in fluid communication with the interior space; a pressure sensor conduit in fluid communication with the interior space; a pressure sensor in fluid communication with the pressure sensor conduit; a reduced-pressure source in fluid communication with the source conduit and operable to deliver reduced pressure to the source conduit; a power sensor that produces supply data indicative of reduced pressure made available to the source conduit; and a reduced-pressure control unit associated with the pressure sensor and reduced-pressure source, the reduced-pressure control unit operable to receive pressure data from the pressure sensor and operable to receive the supply data from the power sensor and to determine when a reservoir-full/blockage condition exists.