A method for filling a container with a medicinal liquid and for closing the container, said method comprising the following method steps: providing a container with a closure, placement of the unfilled container with the closure in a first clean room having a predetermined clean room classification, transferring the container to a second clean room having a clean room classification that is higher than the clean room classification of the first clean room, filling of the container with a medicinal liquid, and removing of the filled and closed container from the second clean room, characterized in that a sterilized container with a closure is provided having a fastening piece with a passage, which is mounted onto the container and has a connecting piece with a passage, which can be connected to a connecting part of a filling device; between the fastening piece and the connecting piece, a closure element is provided, which has an opening that connects the passage of the fastening piece and the connecting piece; in the opening of the closure element, a closure piece moveable between a position that opens the passage of the fastening piece or connecting piece and a position that closes the passage of the fastening piece or connecting piece; and a removable protective cap is placed onto the closure and seals the opening of the connecting piece in a germ-sealed fashion, only the closure of the container is transferred into the second clean room, with the protective cap being removed in the lock zone between the first and second clean rooms, in order to fill the container with a medicinal liquid in the second clean room, the connecting part of a filling device is connected to the connecting piece of the closure, and before the removal of the filled and closed container from the second clean room, the closure piece of the closure element is slid into the position that closes the passage of the connecting piece or fastening piece. providing a container with a closure, placement of the unfilled container with the closure in a first clean room having a predetermined clean room classification, transferring the container to a second clean room having a clean room classification that is higher than the clean room classification of the first clean room, filling of the container with a medicinal liquid, and removing of the filled and closed container from the second clean room, characterized in that a sterilized container with a closure is provided having a fastening piece with a passage, which is mounted onto the container and has a connecting piece with a passage, which can be connected to a connecting part of a filling device; between the fastening piece and the connecting piece, a closure element is provided, which has an opening that connects the passage of the fastening piece and the connecting piece; in the opening of the closure element, a closure piece moveable between a position that opens the passage of the fastening piece or connecting piece and a position that closes the passage of the fastening piece or connecting piece; and a removable protective cap is placed onto the closure and seals the opening of the connecting piece in a germ-sealed fashion, only the closure of the container is transferred into the second clean room, with the protective cap being removed in the lock zone between the first and second clean rooms, in order to fill the container with a medicinal liquid in the second clean room, the connecting part of a filling device is connected to the connecting piece of the closure, and before the removal of the filled and closed container from the second clean room, the closure piece of the closure element is slid into the position that closes the passage of the connecting piece or fastening piece.