Compound of formula in which A is oxygen or sulfur, R 1 is hydrogen or a group of the formula or in which # is the attachment to the oxygen-atom, L 1 is linear (C 2 -C 4)-alkanediyl, L 2 is linear (C 1 -C 3)-alkanediyl, R 5 and R 8 are identical or different and independently selected from the group consisting of hydrogen, methyl, propan-2-yl, propan-1-yl, 2-methylpropan-l-yl, 1-methylpropan-1-yl, butan-1-yl, tert-butyl, phenyl, benzyl, p-hydroxybenzyl, indol-3-ylmethyl, imidazol-4-ylmethyl, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, mercaptomethyl, methylthiomethyl, 2-mercaptoethyl, 2-methylthioethyl, carbamoylmethyl, 2-carbamoylethyl, carboxymethyl, 2-carboxyethyl, 4-aminobutan-1-yl, 4-amino-3-hydroxybutan-1-yl, 3-aminopropan-1-yl, 2-aminomethyl, aminomethyl, 3-guanidinopropan-1-yl, 3-ureidopropan-1-yl, R 6 and R 9 are independently selected from hydrogen or methyl, R 7 is hydrogen or (C 1 -C 4)-alkyl, or R 7 and R 5 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, R 10 and R 11 are identical or different and are indenpentdently selected from hydrogen or (C 1 -C 4)-alkyl, wherein (C 1 -C 4)-alkyl may be substituted with one group selected from hydroxy, (C 1 -C 4)-alkoxy, amino, mono-(C 1 -C 4)-alkylamino or di-(C 1 -C 4)-alkylamino, or R 10 and R 8 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, and R 12 is hydrogen or hydroxycarbonyl, R 2 is hydrogen or a group of the formula -CH 2 OR 1, wherein R 1 is defined as above, R 3 is hydrogen, methyl or ethyl, R 4 is hydrogen, methyl or ethyl, or R 3 and R 4 form together with the nitrogen-atom, which they are bound to, a azetidine-, pyrrolidine- or piperidine-ring, wherein the azetidine-, pyrrolidine- or piperidine-ring may be substituted with one or 2 substituents independently selected from the group fluoro, trifluoromethyl, methyl, ethyl, methoxy and ethoxy, or their salts, solvates and solvates of the salts for the use in a method for the treatment and/or prophylaxis of glaucoma, normotensive glaucoma, ocular hypertension and/or combinations thereof. A is oxygen or sulfur, R 1 is hydrogen or a group of the formula or in which # is the attachment to the oxygen-atom, L 1 is linear (C 2 -C 4)-alkanediyl, L 2 is linear (C 1 -C 3)-alkanediyl, R 5 and R 8 are identical or different and independently selected from the group consisting of hydrogen, methyl, propan-2-yl, propan-1-yl, 2-methylpropan-l-yl, 1-methylpropan-1-yl, butan-1-yl, tert-butyl, phenyl, benzyl, p-hydroxybenzyl, indol-3-ylmethyl, imidazol-4-ylmethyl, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, mercaptomethyl, methylthiomethyl, 2-mercaptoethyl, 2-methylthioethyl, carbamoylmethyl, 2-carbamoylethyl, carboxymethyl, 2-carboxyethyl, 4-aminobutan-1-yl, 4-amino-3-hydroxybutan-1-yl, 3-aminopropan-1-yl, 2-aminomethyl, aminomethyl, 3-guanidinopropan-1-yl, 3-ureidopropan-1-yl, R 6 and R 9 are independently selected from hydrogen or methyl, R 7 is hydrogen or (C 1 -C 4)-alkyl, or R 7 and R 5 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, R 10 and R 11 are identical or different and are indenpentdently selected from hydrogen or (C 1 -C 4)-alkyl, wherein (C 1 -C 4)-alkyl may be substituted with one group selected from hydroxy, (C 1 -C 4)-alkoxy, amino, mono-(C 1 -C 4)-alkylamino or di-(C 1 -C 4)-alkylamino, or R 10 and R 8 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, and R 12 is hydrogen or hydroxycarbonyl, # is the attachment to the oxygen-atom, L 1 is linear (C 2 -C 4)-alkanediyl, L 2 is linear (C 1 -C 3)-alkanediyl, R 5 and R 8 are identical or different and independently selected from the group consisting of hydrogen, methyl, propan-2-yl, propan-1-yl, 2-methylpropan-l-yl, 1-methylpropan-1-yl, butan-1-yl, tert-butyl, phenyl, benzyl, p-hydroxybenzyl, indol-3-ylmethyl, imidazol-4-ylmethyl, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, mercaptomethyl, methylthiomethyl, 2-mercaptoethyl, 2-methylthioethyl, carbamoylmethyl, 2-carbamoylethyl, carboxymethyl, 2-carboxyethyl, 4-aminobutan-1-yl, 4-amino-3-hydroxybutan-1-yl, 3-aminopropan-1-yl, 2-aminomethyl, aminomethyl, 3-guanidinopropan-1-yl, 3-ureidopropan-1-yl, R 6 and R 9 are independently selected from hydrogen or methyl, R 7 is hydrogen or (C 1 -C 4)-alkyl, or R 7 and R 5 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, R 10 and R 11 are identical or different and are indenpentdently selected from hydrogen or (C 1 -C 4)-alkyl, wherein (C 1 -C 4)-alkyl may be substituted with one group selected from hydroxy, (C 1 -C 4)-alkoxy, amino, mono-(C 1 -C 4)-alkylamino or di-(C 1 -C 4)-alkylamino, or R 10 and R 8 form together with the atoms which they are attached to a pyrrolidine- or piperidine-ring, and R 12 is hydrogen or hydroxycarbonyl, R 2 is hydrogen or a group of the formula -CH 2 OR 1, wherein R 1 is defined as above, R 3 is hydrogen, methyl or ethyl, R 4 is hydrogen, methyl or ethyl, R 3 and R 4 form together with the nitrogen-atom, which they are bound to, a azetidine-, pyrrolidine- or piperidine-ring, wherein the azetidine-, pyrrolidine- or piperidine-ring may be substituted with one or 2 substituents independently selected from the group fluoro, trifluoromethyl, methyl, ethyl, methoxy and ethoxy,