A targeting system (10, 310, 410, 910, 1010, 1210) for providing visualization of a trajectory for a medical instrument, the targeting system (10, 310, 410, 1210) comprising: a fixture (28, 128, 413, 1230) comprising a first attachment feature that secures the fixture at a predetermined location relative to a patient; a first laser (12, 312, 412, 1212), wherein the first laser projects first light along a first plane; and a second laser (14, 314, 414, 1214), wherein the second laser projects second light along a second plane nonparallel to the first plane such that, at an intersection of the first plane with the second plane, the first light and the second light cooperate to produce a first targeting line that indicates the trajectory; wherein the first light comprises a first wavelength corresponding to a first color within the visible portion of the electromagnetic spectrum; wherein the second light comprises a second wavelength corresponding to a second color within the visible portion of the electromagnetic spectrum; wherein the second wavelength is different from the first wavelength and the second color is different from the first color; characterized in that the first laser (12, 312, 412, 1212) and second laser (14, 314, 414, 1214) are both attached to the fixture; wherein the first laser (12, 312, 412, 1212) is adjustably attached to the fixture (28, 128, 413, 1230) such that adjustment of at least one of a first roll setting, a first pitch setting, and a first yaw setting of the first laser (12, 312, 412, 1212) is adjustable to adjust a first orientation of the first plane, relative to the fixture (28, 128, 413, 1230); wherein the second laser (14, 314, 414, 1214) is adjustably attached to the fixture (28, 128, 413, 1230) such that adjustment of at least one of a second roll setting, a second pitch setting, and a second yaw setting of the second laser (14, 314, 414, 1214) is adjustable to adjust a second orientation of the second plane, relative to the fixture (28, 128, 413, 1230). a fixture (28, 128, 413, 1230) comprising a first attachment feature that secures the fixture at a predetermined location relative to a patient; a first laser (12, 312, 412, 1212), wherein the first laser projects first light along a first plane; and a second laser (14, 314, 414, 1214), wherein the second laser projects second light along a second plane nonparallel to the first plane such that, at an intersection of the first plane with the second plane, the first light and the second light cooperate to produce a first targeting line that indicates the trajectory; wherein the first light comprises a first wavelength corresponding to a first color within the visible portion of the electromagnetic spectrum; wherein the second light comprises a second wavelength corresponding to a second color within the visible portion of the electromagnetic spectrum; wherein the second wavelength is different from the first wavelength and the second color is different from the first color; characterized in that the first laser (12, 312, 412, 1212) and second laser (14, 314, 414, 1214) are both attached to the fixture; wherein the first laser (12, 312, 412, 1212) is adjustably attached to the fixture (28, 128, 413, 1230) such that adjustment of at least one of a first roll setting, a first pitch setting, and a first yaw setting of the first laser (12, 312, 412, 1212) is adjustable to adjust a first orientation of the first plane, relative to the fixture (28, 128, 413, 1230); wherein the second laser (14, 314, 414, 1214) is adjustably attached to the fixture (28, 128, 413, 1230) such that adjustment of at least one of a second roll setting, a second pitch setting, and a second yaw setting of the second laser (14, 314, 414, 1214) is adjustable to adjust a second orientation of the second plane, relative to the fixture (28, 128, 413, 1230).