A compound of Formula, or a pharmaceutically acceptable salt thereof, having the structure: wherein: R 1 is selected from the group consisting of hydrogen, halogen and a substituted or unsubstituted C 1 -C 6 alkyl; Ring A is selected from the group consisting of a substituted or unsubstituted phenyl and a substituted or unsubstituted 5-6 membered monocyclic heteroaryl; Ring B is selected from the group consisting of a substituted or unsubstituted monocyclic 5-7 membered carbocyclyl and a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl; R 2 is selected from the group consisting of m is 0, 1, 2 or 3; R 3 is selected from the group consisting of halogen and a substituted or unsubstituted C 1 -C 6 alkyl; X is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, a substituted or unsubstituted 4-6 membered monocyclic heterocyclyl, a substituted or unsubstituted amine(C 1 -C 6 alkyl), a substituted or unsubstituted -NH-(CH 2) 1-6 -amine, a mono-substituted amine, a di-substituted amine, an amino, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 alkoxy, a substituted or unsubstituted C 3 -C 6 cycloalkoxy, a substituted or unsubstituted (C 1 -C 6 alkyl)acyl, a substituted or unsubstituted C-amido, a substituted or unsubstituted N-amido, a substituted or unsubstituted C-carboxy, a substituted or unsubstituted O-carboxy, a substituted or unsubstituted O-carbamyl and a substituted or unsubstituted N-carbamyl; Y is CH or N; Y 1 is CR 4A or N; Y 2 is CR 4B or N; Ring C is selected from the group consisting of a substituted or unsubstituted C 6 -C 10 aryl, a substituted or unsubstituted monocyclic 5-10 membered heteroaryl, a substituted or unsubstituted monocyclic 5-7 membered carbocyclyl, a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl and a substituted or unsubstituted 7-10 membered bicyclic heterocyclyl; R 4A and R 4B are independently selected from the group consisting of hydrogen, halogen and an unsubstituted C 1-4 alkyl; and R 5 is a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl. R 1 is selected from the group consisting of hydrogen, halogen and a substituted or unsubstituted C 1 -C 6 alkyl; Ring A is selected from the group consisting of a substituted or unsubstituted phenyl and a substituted or unsubstituted 5-6 membered monocyclic heteroaryl; Ring B is selected from the group consisting of a substituted or unsubstituted monocyclic 5-7 membered carbocyclyl and a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl; R 2 is selected from the group consisting of m is 0, 1, 2 or 3; R 3 is selected from the group consisting of halogen and a substituted or unsubstituted C 1 -C 6 alkyl; X is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, a substituted or unsubstituted 4-6 membered monocyclic heterocyclyl, a substituted or unsubstituted amine(C 1 -C 6 alkyl), a substituted or unsubstituted -NH-(CH 2) 1-6 -amine, a mono-substituted amine, a di-substituted amine, an amino, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 alkoxy, a substituted or unsubstituted C 3 -C 6 cycloalkoxy, a substituted or unsubstituted (C 1 -C 6 alkyl)acyl, a substituted or unsubstituted C-amido, a substituted or unsubstituted N-amido, a substituted or unsubstituted C-carboxy, a substituted or unsubstituted O-carboxy, a substituted or unsubstituted O-carbamyl and a substituted or unsubstituted N-carbamyl; Y is CH or N; Y 1 is CR 4A or N; Y 2 is CR 4B or N; Ring C is selected from the group consisting of a substituted or unsubstituted C 6 -C 10 aryl, a substituted or unsubstituted monocyclic 5-10 membered heteroaryl, a substituted or unsubstituted monocyclic 5-7 membered carbocyclyl, a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl and a substituted or unsubstituted 7-10 membered bicyclic heterocyclyl; R 4A and R 4B are independently selected from the group consisting of hydrogen, halogen and an unsubstituted C 1-4 alkyl; and R 5 is a substituted or unsubstituted 5-7 membered monocyclic heterocyclyl.