mhurhangee/ep-ind-claims huggingface dataset:
A semiconductor package, comprising: a substrate; a semiconductor die mounted on the substrate; and a heatsink over the semiconductor die, wherein the heatsink comprises a roof portion and at least one connecting portion extending between the roof portion and the substrate, wherein the at least one connecting portion comprises a connection lead mounted on a connection pad of the substrate, wherein the connection pad is disposed on a chip side of the substrate and comprises a first portion and a second portion spaced apart from each other, which are configured to electrically couple to different voltage signals, respectively; the connection lead is attached to the first portion through a first conductive adhesion layer, characterized in that the connection lead is attached to the second portion through a second conductive adhesion layer that is not in direct contact with the first conductive adhesion layer. a substrate; a semiconductor die mounted on the substrate; and a heatsink over the semiconductor die, wherein the heatsink comprises a roof portion and at least one connecting portion extending between the roof portion and the substrate, wherein the at least one connecting portion comprises a connection lead mounted on a connection pad of the substrate, wherein the connection pad is disposed on a chip side of the substrate and comprises a first portion and a second portion spaced apart from each other, which are configured to electrically couple to different voltage signals, respectively; the connection lead is attached to the first portion through a first conductive adhesion layer, characterized in that the connection lead is attached to the second portion through a second conductive adhesion layer that is not in direct contact with the first conductive adhesion layer.
Method for evaluating the reliability of a route in a cooperative network for the transmission of data packets between a source node and a destination node of the network, comprising a step of updating a database that is administered by the destination node and comprises records relating to nodes of the network, each record comprising an identification of one said node of the network and at least one item of information relating to this node comprising a confidence index associated with this node, said confidence index being updated during the updating step on the basis of data packets correctly forwarded to the destination node via at least one route comprising said node, said method comprising, upon reception by the destination node of each route request message indicating a route between said source node and the destination node: - a step of the destination node evaluating at least one parameter indicative of reliability on the basis of said items of information that are contained in the database administered by the destination node and relate to the network nodes through which the indicated route passes, - a step of the destination node associating said at least one parameter indicative of reliability with the indicated route, and - a step of the destination node sending the source node a response comprising said at least one parameter indicative of reliability that is associated with the indicated route. - a step of the destination node evaluating at least one parameter indicative of reliability on the basis of said items of information that are contained in the database administered by the destination node and relate to the network nodes through which the indicated route passes, - a step of the destination node associating said at least one parameter indicative of reliability with the indicated route, and - a step of the destination node sending the source node a response comprising said at least one parameter indicative of reliability that is associated with the indicated route.
A gas turbine engine with a seal arrangement comprising: a first outer skin and a second outer skin disposed about an axial centerline of the gas turbine engine and forming portions of a nacelle of the gas turbine engine, the second outer skin adjacent the first outer skin and comprising at least one cowl door; a bulkhead extending substantially radially at least a portion of a distance between the axial centerline and one of the first outer skin and the second outer skin; a first outer frame comprising a first portion, a second portion, and a third portion, the first portion of the first outer frame mounted to the bulkhead; and a seal mounted to one of the at least one cowl door and the second portion, wherein the at least one cowl door is rotatable between a first position and a second position and wherein in the second position the seal is in contact with the at least one cowl door and the second portion, characterised in that the third portion is configured to limit a compression of the seal between the at least one cowl door and the second portion. a first outer skin and a second outer skin disposed about an axial centerline of the gas turbine engine and forming portions of a nacelle of the gas turbine engine, the second outer skin adjacent the first outer skin and comprising at least one cowl door; a bulkhead extending substantially radially at least a portion of a distance between the axial centerline and one of the first outer skin and the second outer skin; a first outer frame comprising a first portion, a second portion, and a third portion, the first portion of the first outer frame mounted to the bulkhead; and a seal mounted to one of the at least one cowl door and the second portion, wherein the at least one cowl door is rotatable between a first position and a second position and wherein in the second position the seal is in contact with the at least one cowl door and the second portion, characterised in that the third portion is configured to limit a compression of the seal between the at least one cowl door and the second portion.
A single composition comprising: (a) a monoclonal antibody, or an antigen-binding portion thereof, that binds human lymphocyte activation gene-3 (LAG-3), (b) an anti-PD-1 antibody, or an antigen-binding portion thereof, and (c) a pharmaceutically acceptable carrier; wherein the monoclonal antibody or antigen-binding portion thereof that binds human LAG-3 comprises heavy chain CDR1, CDR2, and CDR3 regions comprising the amino acid sequences of SEQ ID NOs: 15, 16, and 17, respectively, and light chain CDR1, CDR2, and CDR3 regions comprising the amino acid sequences of SEQ ID NOs: 18, 19, and 20, respectively. (a) a monoclonal antibody, or an antigen-binding portion thereof, that binds human lymphocyte activation gene-3 (LAG-3), (b) an anti-PD-1 antibody, or an antigen-binding portion thereof, and (c) a pharmaceutically acceptable carrier;
An oil filter, comprising: a housing including: an inlet; an outlet; and a filter element located downstream of the inlet and upstream of the outlet, the filter element including: a filtering material; and a tracer material comprising at least one of chromophores or organometallics of zirconium, cerium, yttrium, scandium, lanthanum, or other heavy elements; wherein the filtering material is formed by an additive manufacturing process, and wherein the tracer material is added to the filter element by the additive manufacturing process. an inlet; an outlet; and a filter element located downstream of the inlet and upstream of the outlet, the filter element including: a filtering material; and a tracer material comprising at least one of chromophores or organometallics of zirconium, cerium, yttrium, scandium, lanthanum, or other heavy elements; wherein the filtering material is formed by an additive manufacturing process, and wherein the tracer material is added to the filter element by the additive manufacturing process. a filtering material; and a tracer material comprising at least one of chromophores or organometallics of zirconium, cerium, yttrium, scandium, lanthanum, or other heavy elements; wherein the filtering material is formed by an additive manufacturing process, and wherein the tracer material is added to the filter element by the additive manufacturing process.
A method of ex-vivo culturing natural killer cells, the method comprising culturing a population of T-cell depleted cells comprising NK cells with IL-15 and exposing said NK cells to 1 to 10 mM nicotinamide for a duration of exposure of 12-23 hours, wherein culturing said NK cells with IL-15 and said exposing to said nicotinamide results in: (a) elevated expression of CD62L as compared to T-cell depleted NK cells cultured under otherwise identical culturing conditions with less than 0.1 mM of said nicotinamide, and (b) greater cytotoxicity as compared to T-cell depleted NK cells cultured under otherwise identical culturing conditions with less than 0.1 mM of said nicotinamide. (b) greater cytotoxicity as compared to T-cell depleted NK cells cultured under otherwise identical culturing conditions with less than 0.1 mM of said nicotinamide.
A system for thermoformable film packaging of portioned products, the system including a mold assembly comprising at least one mold the shape of which corresponds to the shape of the portioned products, at least one thermoforming tool and at least one sealing tool, the system being adapted to package the portioned products in a lower thermoformable film which is shaped in the mold by means of the thermoforming tool and sealed with an upperfilm by means of the sealing tool, wherein each of the tools (18, 19) is translated back and forth between its position of pressure against the mold assembly and its position spaced from the mold assembly, characterized in that each form is made of a material having thermal conductivity of at most 0,5 W/(m·K), and in that each sealing tool is provided with an elastic heat conductive layer contacting the sealed film, the layer being made of a material having thermal conductivity of at least 3 W/(m·K).
An injection molding system comprising; a hot runner manifold formed from two complementary plates fastened together along complementary contacting surfaces (B L), the manifold includes at least one melt channel (303,305,306) for conducting a melt stream of moldable material therethrough and further contains a heater for heating the melt stream in the melt channel (303,305,306), the melt channel (303,305,306) is formed within the complementary contacting surfaces (B L), wherein the melt channel (303,305,306) has a noncircular cross-section characterized in that the melt channel (303, 305, 306) is offset towards one of the two complementary plates.
A reader for electro-optically reading a target by image capture, comprising: a housing having a window; a solid-state imager supported by the housing, and having an array of sensors with a field of view in which the target is located during reading; and an imaging lens assembly having an optical axis, and operative for capturing return light through the window from the target located in a range of working distances along the optical axis away from the window, and for projecting the captured return light onto the array; characterized by: the imaging lens assembly being optically modified for non-uniform magnification within, and increasing resolution at an outer peripheral region of, the field of view in an imaging plane generally perpendicular to the optical axis, the magnification at least partly increasing in the imaging plane with increasing radial distance away from the optical axis, to enable reading of the target when tilted relative to the optical axis and located at the outer peripheral region of the field of view, wherein the optically modified imaging lens assembly gradually increases the magnification in the imaging plane with increasing radial distance away from the optical axis until the outer peripheral region of the field of view is reached, and then gradually decreases the magnification in the imaging plane with increasing radial distance away from the optical axis as the outer peripheral region of the field of view is traversed. a housing having a window; a solid-state imager supported by the housing, and having an array of sensors with a field of view in which the target is located during reading; and an imaging lens assembly having an optical axis, and operative for capturing return light through the window from the target located in a range of working distances along the optical axis away from the window, and for projecting the captured return light onto the array; the imaging lens assembly being optically modified for non-uniform magnification within, and increasing resolution at an outer peripheral region of, the field of view in an imaging plane generally perpendicular to the optical axis, the magnification at least partly increasing in the imaging plane with increasing radial distance away from the optical axis, to enable reading of the target when tilted relative to the optical axis and located at the outer peripheral region of the field of view, wherein the optically modified imaging lens assembly gradually increases the magnification in the imaging plane with increasing radial distance away from the optical axis until the outer peripheral region of the field of view is reached, and then gradually decreases the magnification in the imaging plane with increasing radial distance away from the optical axis as the outer peripheral region of the field of view is traversed.
A method for establishing an APOE gene knock-out canine model demonstrating an atherosclerotic phenotype, comprising the following steps: determining a targeting site sequence directed to an exon sequence of canine APOE gene sequence; synthesizing sgRNA sequence and the complementary sequence thereof according to the targeting site sequence determined in step, then linking the synthesized sequence with a skeleton vector to construct a sgRNA targeting vector; in vitro transcripting the sgRNA targeting vector to obtain mRNA thereof, and in vitro transcripting CRISPR/Cas9 to obtain mRNA thereof; mixing the mRNA of sgRNA and mRNA of CRISPR/Cas9 obtained in step, and then intracytoplasmic injecting thereof into the fertilized ovum; and transplanting the fertilized ovum into less bleeding fallopian tubes of a female canine of which both fallopian tubes have been embryo flushed; the exon in step is exon 3 whose sequence is as shown in SEQ ID NO: 2; and the targeting site sequence is the sequence determined directed to exon 3 as follows: 5'-CCGGGTGGCAGACTGGCCAGCCC-3' (SEQ ID NO: 4); and the synthesized sgRNA sequence and the complementary sequence thereof in step are as follows: sgRNA sequence: ataGGGCTGGCCAGTCTGCCACCgt (SEQ ID NO: 5); and the complementary sequence of sgRNA sequence: taaaacGGTGG CAGACTGGCCAGCC (SEQ ID NO: 6). determining a targeting site sequence directed to an exon sequence of canine APOE gene sequence; synthesizing sgRNA sequence and the complementary sequence thereof according to the targeting site sequence determined in step, then linking the synthesized sequence with a skeleton vector to construct a sgRNA targeting vector; in vitro transcripting the sgRNA targeting vector to obtain mRNA thereof, and in vitro transcripting CRISPR/Cas9 to obtain mRNA thereof; mixing the mRNA of sgRNA and mRNA of CRISPR/Cas9 obtained in step, and then intracytoplasmic injecting thereof into the fertilized ovum; and transplanting the fertilized ovum into less bleeding fallopian tubes of a female canine of which both fallopian tubes have been embryo flushed; the exon in step is exon 3 whose sequence is as shown in SEQ ID NO: 2; and the targeting site sequence is the sequence determined directed to exon 3 as follows: 5'-CCGGGTGGCAGACTGGCCAGCCC-3' (SEQ ID NO: 4); and the synthesized sgRNA sequence and the complementary sequence thereof in step are as follows: sgRNA sequence: ataGGGCTGGCCAGTCTGCCACCgt (SEQ ID NO: 5); and the complementary sequence of sgRNA sequence: taaaacGGTGG CAGACTGGCCAGCC (SEQ ID NO: 6). the exon in step is exon 3 whose sequence is as shown in SEQ ID NO: 2; and the targeting site sequence is the sequence determined directed to exon 3 as follows: 5'-CCGGGTGGCAGACTGGCCAGCCC-3' (SEQ ID NO: 4); and the synthesized sgRNA sequence and the complementary sequence thereof in step are as follows: sgRNA sequence: ataGGGCTGGCCAGTCTGCCACCgt (SEQ ID NO: 5); and the complementary sequence of sgRNA sequence: taaaacGGTGG CAGACTGGCCAGCC (SEQ ID NO: 6). sgRNA sequence: ataGGGCTGGCCAGTCTGCCACCgt (SEQ ID NO: 5); and the complementary sequence of sgRNA sequence: taaaacGGTGG CAGACTGGCCAGCC (SEQ ID NO: 6).
A connection system for fluid-flowing components for medical and/or medical technology, having an actuator having a cylindrical portion with an outer surface, - wherein a handle is arranged at a first end of the cylindrical portion, - wherein the cylindrical portion has a hollow space in the region of a second end, which is open towards the second end, and - wherein at least two gate-shaped passage openings (110, 120, 130) for a fluid connection are arranged in the region of the second end, and a base housing, having a base body and at least two fluid passages (210, 220, 230) arranged laterally on the base body, - wherein the base body has a cavity with an open first end, a base in the region of a second end and at least two laterally arranged openings (214, 224, 234), which each establish a fluid connection to the corresponding fluid passages (210, 220, 230), - wherein the cavity receives the cylindrical portion of the actuator in a rotatable manner through the open first end and the inner diameter of the cavity corresponds to the outer diameter of the cylindrical portion of the actuator, and - wherein the laterally arranged openings (214, 224, 234) correspond to the passage openings (110, 120, 130) of the actuator, characterised in that a substantially cylindrical pin for supporting the second end of the actuator is arranged on the base of the base body, and a circumferential groove is formed in the region of the second end of the actuator, which groove at least partially embraces the pin and thus forms a counter-bearing for the second end of the actuator, wherein the groove contacts the pin, and the upper edge of the pin is not higher than the lower edge of one of the fluid passages (210, 220, 230). - wherein a handle is arranged at a first end of the cylindrical portion, - wherein the cylindrical portion has a hollow space in the region of a second end, which is open towards the second end, and - wherein at least two gate-shaped passage openings (110, 120, 130) for a fluid connection are arranged in the region of the second end, and - wherein the base body has a cavity with an open first end, a base in the region of a second end and at least two laterally arranged openings (214, 224, 234), which each establish a fluid connection to the corresponding fluid passages (210, 220, 230), - wherein the cavity receives the cylindrical portion of the actuator in a rotatable manner through the open first end and the inner diameter of the cavity corresponds to the outer diameter of the cylindrical portion of the actuator, and - wherein the laterally arranged openings (214, 224, 234) correspond to the passage openings (110, 120, 130) of the actuator, a substantially cylindrical pin for supporting the second end of the actuator is arranged on the base of the base body, and a circumferential groove is formed in the region of the second end of the actuator, which groove at least partially embraces the pin and thus forms a counter-bearing for the second end of the actuator, wherein the groove contacts the pin, and the upper edge of the pin is not higher than the lower edge of one of the fluid passages (210, 220, 230).
A semi-finished product for semi-finished components for manufacturing a heat exchanger, in particular according to a CAB soldering process, from a core material and at least on one side with a solder layer and a corrosion-reducing intermediate layer, disposed between the solder layer and the core material, wherein the core material consists of an Al3000 alloy or an Al6000 alloy, which has 0.1% to 1.5% Mg, wherein the solder layer consists of an Al4000 alloy, which has a maximum of 0.2% Mg, wherein the corrosion-reducing intermediate layer consists of an Al1000 alloy or an Al7000 alloy, which has 0.1% to 1.5% Mg. wherein the core material consists of an Al3000 alloy or an Al6000 alloy, which has 0.1% to 1.5% Mg, wherein the solder layer consists of an Al4000 alloy, which has a maximum of 0.2% Mg, wherein the corrosion-reducing intermediate layer consists of an Al1000 alloy or an Al7000 alloy, which has 0.1% to 1.5% Mg.
An electric power tool including a motor accommodated in a housing and serving as a drive power source; a speed reduction mechanism adapted to transfer a rotational driving force to a tool part provided at a front side of the housing; and a cylindrical reducer case, accommodated in the housing and accommodating therein the speed reduction mechanism, wherein the speed reduction mechanism includes a planetary gear train and a movable member which is slidable in an axial direction of the planetary gear train to be engaged with or disengaged from the planetary gear train, and a reduction ratio thereof is changeable at a plurality of stages by controlling the movement of the movable member, the electric power tool comprising: the reducer case including a slide hole formed through a sidewall of the reducer case and extended along the axial direction and a rotary plate which is rotatable around a periphery of the reducer case about the axis, the rotary plate including an operation slot formed obliquely with respect to the axial direction and overlapped with the slide hole; a supporting member radially outwardly protruded from the movable member and extended through the slide hole and the operation slot; a driving unit adapted to drive the rotary plate along the periphery of the reducer case; and a biasing unit adapted to apply a pressing force to the supporting member in a moving direction of the supporting member when the rotary plate is rotated to a position by the driving unit. the reducer case including a slide hole formed through a sidewall of the reducer case and extended along the axial direction and a rotary plate which is rotatable around a periphery of the reducer case about the axis, the rotary plate including an operation slot formed obliquely with respect to the axial direction and overlapped with the slide hole; a supporting member radially outwardly protruded from the movable member and extended through the slide hole and the operation slot; a driving unit adapted to drive the rotary plate along the periphery of the reducer case; and a biasing unit adapted to apply a pressing force to the supporting member in a moving direction of the supporting member when the rotary plate is rotated to a position by the driving unit.
An intracorporeal device for supporting heart function of a patient, wherein said device is adapted and configured to be secured across at least two anatomical walls of the heart, comprising a proximal portion intended to be positioned in a first anatomical compartment, an intermediate portion intended to be positioned in a second anatomical compartment, a distal portion intended to be positioned in a third anatomical compartment, characterised in that the device comprises a motor M located in the proximal portion, one or more fluid inlet ports in the intermediate portion, a pump P in the intermediate portion, and one or more fluid outlet ports in the distal portion.