Use of a compound of formula or any pharmaceutically acceptable salt or solvate thereof, wherein: R B is a group selected from R 3, R 4, R' 2, R' 3, R' 4, R' 5 and R' 6 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, -C(=O)R 7, -C(=O)OR 8, -C(=O)NR 9 R 10, -C=NR 11, -CN, -OR 12, - OC(=O)R 13, -S t -R 14,-NR 15 R 16, -NR 17 C(=O)R 18, -NO 2, -N=CR 19 R 20 or halogen, wherein R 3 and R 4 together may form a =O group, and wherein any pair of R 3 R' 2, R 3 R' 6, R 4 R' 2, R 4 R' 6, R' 2 R' 3, R' 3 R' 4, R' 4 R' 5, R' 5 R' 6, R 15 R 16, R 17 R 18 or R 19 R 20 may form together a cyclic substituent; t is 0, 1, 2, 3 R 7, R 8, R 9, R 10, R 11, R 13, R 14, R 15, R 16, R 17, R 18, R 19 and R 20 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted alkoxy, substituted or unsubstituted ariloxy, halogen, R 12 is selected from hydrogen, unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, halogen, in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition wherein the disease or condition is selected from the group of diabetes, conditions associated with diabetes, chronic neurodegenerative conditions including dementias such as Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, subacute sclerosing panencephalitic parkinsonism, postencephalitic parkinsonism, pugilistic encephalitis, guam parkinsonism-dementia complex, Pick's disease, corticobasal degeneration, frontotemporal dementia, Huntington's Disease, AIDS associated dementia, amyotrophic lateral sclerosis, multiple sclerosis and neurotraumatic diseases such as acute stroke, epilepsy, mood disorders such as depression, schizophrenia and bipolar disorders, promotion of functional recovery post stroke, cerebral bleeding such as due to solitary cerebral amyloid angiopathy, hair loss, obesity, hypertension, polycystic ovary syndrome, syndrome X, ischaemia, brain injury, traumatic brain injury, cancer, leukopenia, Down's syndrome, Lewy body disease, inflammation, chronic inflammatory diseases, cancer and hyperproliferative diseases as hyperplasias and immunodeficiency. R B is a group selected from R 3, R 4, R' 2, R' 3, R' 4, R' 5 and R' 6 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, -C(=O)R 7, -C(=O)OR 8, -C(=O)NR 9 R 10, -C=NR 11, -CN, -OR 12, - OC(=O)R 13, -S t -R 14,-NR 15 R 16, -NR 17 C(=O)R 18, -NO 2, -N=CR 19 R 20 or halogen, wherein R 3 and R 4 together may form a =O group, and wherein any pair of R 3 R' 2, R 3 R' 6, R 4 R' 2, R 4 R' 6, R' 2 R' 3, R' 3 R' 4, R' 4 R' 5, R' 5 R' 6, R 15 R 16, R 17 R 18 or R 19 R 20 may form together a cyclic substituent; t is 0, 1, 2, 3 R 7, R 8, R 9, R 10, R 11, R 13, R 14, R 15, R 16, R 17, R 18, R 19 and R 20 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted alkoxy, substituted or unsubstituted ariloxy, halogen, R 12 is selected from hydrogen, unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, halogen, in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition wherein the disease or condition is selected from the group of diabetes, conditions associated with diabetes, chronic neurodegenerative conditions including dementias such as Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, subacute sclerosing panencephalitic parkinsonism, postencephalitic parkinsonism, pugilistic encephalitis, guam parkinsonism-dementia complex, Pick's disease, corticobasal degeneration, frontotemporal dementia, Huntington's Disease, AIDS associated dementia, amyotrophic lateral sclerosis, multiple sclerosis and neurotraumatic diseases such as acute stroke, epilepsy, mood disorders such as depression, schizophrenia and bipolar disorders, promotion of functional recovery post stroke, cerebral bleeding such as due to solitary cerebral amyloid angiopathy, hair loss, obesity, hypertension, polycystic ovary syndrome, syndrome X, ischaemia, brain injury, traumatic brain injury, cancer, leukopenia, Down's syndrome, Lewy body disease, inflammation, chronic inflammatory diseases, cancer and hyperproliferative diseases as hyperplasias and immunodeficiency.