A process for producing a compound of formula, wherein R1 and R2 may be the same or different and represent each a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino, metallocenyl group; R3, R4, R5, R6 may be the same or different and represent each a hydrogen atom or a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino; E represents a substituted or unsubstituted group selected from PR7R8; wherein R7, R8 may be the same or different and represent each an hydrogen, a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino, metallocenyl group; comprising: (i) reacting chlorophosphine borane wherein R1 and R2 are as defined above, with a reagent RM, in which M is a metal, preferably Li and R is an alkyl or an aryl group; and further reacting the product of this halogen-metal exchange with an aromatic compound of general formula wherein X and Y may be the same or different and each represent F, Cl, Br, I, and R3, R4, R5 and R6 are as defines above, resulting in the corresponding P-chirogenic phosphine borane of formula wherein X, R1, R2, R3, R4, R5 and R6 are as defined above; and (ii) performing two chemical transformations on compound leading to compound: a step (ii-a) of removing of the borane group and a step (ii-b) of coupling of an electrophilic reagent on the ortho position or oxidative coupling with an oxidative reagent on the ortho position, optionally followed by an electrophilic coupling on the ortho position; steps (ii-a) and (ii-b) being carried out in any order. R1 and R2 may be the same or different and represent each a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino, metallocenyl group; R3, R4, R5, R6 may be the same or different and represent each a hydrogen atom or a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino; E represents a substituted or unsubstituted group selected from PR7R8; wherein R7, R8 may be the same or different and represent each an hydrogen, a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino, metallocenyl group; comprising: (i) reacting chlorophosphine borane wherein R1 and R2 are as defined above, with a reagent RM, in which M is a metal, preferably Li and R is an alkyl or an aryl group; and further reacting the product of this halogen-metal exchange with an aromatic compound of general formula wherein X and Y may be the same or different and each represent F, Cl, Br, I, and R3, R4, R5 and R6 are as defines above, resulting in the corresponding P-chirogenic phosphine borane of formula wherein X, R1, R2, R3, R4, R5 and R6 are as defined above; and (ii) performing two chemical transformations on compound leading to compound: a step (ii-a) of removing of the borane group and a step (ii-b) of coupling of an electrophilic reagent on the ortho position or oxidative coupling with an oxidative reagent on the ortho position, optionally followed by an electrophilic coupling on the ortho position; steps (ii-a) and (ii-b) being carried out in any order. R7, R8 may be the same or different and represent each an hydrogen, a substituted or unsubstituted group selected from alkyl, cycloalkyl, aryl, alkyloxy, cycloalkyloxy, aryloxy, alkylamino, cycloalkylamino, arylamino, metallocenyl group; (i) reacting chlorophosphine borane wherein R1 and R2 are as defined above, with a reagent RM, in which M is a metal, preferably Li and R is an alkyl or an aryl group; and further reacting the product of this halogen-metal exchange with an aromatic compound of general formula wherein X and Y may be the same or different and each represent F, Cl, Br, I, and R3, R4, R5 and R6 are as defines above, resulting in the corresponding P-chirogenic phosphine borane of formula wherein X, R1, R2, R3, R4, R5 and R6 are as defined above; and (ii) performing two chemical transformations on compound leading to compound: a step (ii-a) of removing of the borane group and a step (ii-b) of coupling of an electrophilic reagent on the ortho position or oxidative coupling with an oxidative reagent on the ortho position, optionally followed by an electrophilic coupling on the ortho position; steps (ii-a) and (ii-b) being carried out in any order.