mhurhangee/ep-ind-claims huggingface dataset:
A peptide conjugate comprising: a) a peptide which is Factor IX and which is covalently attached to a moiety which is a member selected from: wherein the indices m and n are integers independently selected from 100 to 4000, wherein R 2 is a member selected from H, CH 2 OR 7, COOR 7, and OR 7, wherein R 7 is a member selected from H, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl, or wherein said moiety is: wherein m, n and R 2 are as defined above, and wherein R 3 and R 4 are members independently selected from H, substituted or unsubstituted alkyl, OR 8 and NHC R 9, and wherein R 8 and R 9 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, sialic acid and polysialic acid. a) a peptide which is Factor IX and which is covalently attached to a moiety which is a member selected from: wherein the indices m and n are integers independently selected from 100 to 4000, wherein R 2 is a member selected from H, CH 2 OR 7, COOR 7, and OR 7, wherein R 7 is a member selected from H, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl, or wherein said moiety is: wherein m, n and R 2 are as defined above, and wherein R 3 and R 4 are members independently selected from H, substituted or unsubstituted alkyl, OR 8 and NHC R 9, and wherein R 8 and R 9 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, sialic acid and polysialic acid.
A pharmaceutical composition comprising Compound 8: 8 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the pharmaceutical composition has a pH of 4 to 5, wherein the pharmaceutical composition further comprises a citrate buffer and wherein the pharmaceutically acceptable excipient comprises mannitol.
Method for controlling an induction heating system of a cooking appliance provided with an induction coil, particularly for controlling it in connection with a predetermined working condition, characterized in that it comprises measuring the value of at least one electrical parameter of the induction heating system, feeding a computing model with actual switching frequency signals in order to estimate a temperature indicative of the thermal status of the heating system and to provide an estimated value of said electrical parameter, comparing the measured electrical parameter with the estimated one and tuning the computing model on the basis of such comparison.
A bottle assembly comprising: a container having an open end, a closed end, a base portion, and a neck, the neck having a rim defining the open end of the container; a vent assembly positionable on the rim of the container to enable venting of the container during use; and a collar assembly generally defining a closure for the container, the collar assembly configured for releasable engagement with the neck of the container over the open end thereof, the collar assembly comprising a nipple and a collar for selectively holding the nipple on the container, wherein the collar assembly and the container are configured relative to each other to enable selective configuration of the bottle assembly between a first configuration and a second configuration, wherein in the first configuration, the nipple sealingly engages the vent assembly and the collar assembly urges the vent assembly into sealing engagement with the rim of the container, wherein in the second configuration, in which the vent assembly is omitted from the bottle assembly, the nipple sealingly engages the rim of the container, and wherein the nipple comprises a flange having a bottom face, the bottom face of the flange comprising a plurality of vent features which extend radially inward from an outer edge of the flange in an equal, circumferentially-spaced relationship with each other, so that air can enter the container via the vent features in the second configuration. a container having an open end, a closed end, a base portion, and a neck, the neck having a rim defining the open end of the container; a vent assembly positionable on the rim of the container to enable venting of the container during use; and a collar assembly generally defining a closure for the container, the collar assembly configured for releasable engagement with the neck of the container over the open end thereof, the collar assembly comprising a nipple and a collar for selectively holding the nipple on the container, wherein the collar assembly and the container are configured relative to each other to enable selective configuration of the bottle assembly between a first configuration and a second configuration, wherein in the first configuration, the nipple sealingly engages the vent assembly and the collar assembly urges the vent assembly into sealing engagement with the rim of the container, wherein in the second configuration, in which the vent assembly is omitted from the bottle assembly, the nipple sealingly engages the rim of the container, and wherein the nipple comprises a flange having a bottom face, the bottom face of the flange comprising a plurality of vent features which extend radially inward from an outer edge of the flange in an equal, circumferentially-spaced relationship with each other, so that air can enter the container via the vent features in the second configuration.
Water jet surgical device, comprising a liquid conveying device which is actuatable by means of actuation signals from a control device so as to dispense a liquid into an attachment line of a surgical instrument with an outlet nozzle, characterized in that at least one measuring device (41 - 43) is provided and is designed such that, after the surgical instrument has been attached to the liquid conveying device, the measuring device (41 - 43) generates measuring signals in order to show, on a display or registering unit, a quantity of liquid actually dispensed from the outlet nozzle.
A method of controlling channel assessment at a coordinator of a wireless network, the method comprising: transmitting a first information element to request assessment of a channel which is currently used in the wireless network wherein the first information element is broadcasted by the coordinator to request the channel assessment to all devices of the wireless network, and wherein each device of the wireless network decides whether to perform the channel assessment; receiving a response to the request of the channel assessment from at least one device of the wireless network, the response confirming that the channel assessment will be performed by the at least one device which has decided to perform the channel assessment; broadcasting a beacon comprising information for allocating a channel time block during which the channel assessment is to be performed by the at least one device, wherein data transmission by all devices in the wireless network is not allowed during the channel time block and receiving a result of the channel assessment from the at least one device. transmitting a first information element to request assessment of a channel which is currently used in the wireless network wherein the first information element is broadcasted by the coordinator to request the channel assessment to all devices of the wireless network, and wherein each device of the wireless network decides whether to perform the channel assessment; receiving a response to the request of the channel assessment from at least one device of the wireless network, the response confirming that the channel assessment will be performed by the at least one device which has decided to perform the channel assessment; broadcasting a beacon comprising information for allocating a channel time block during which the channel assessment is to be performed by the at least one device, wherein data transmission by all devices in the wireless network is not allowed during the channel time block and receiving a result of the channel assessment from the at least one device.
An isolated recombinant antibody or an antigen-binding fragment thereof that is a single chain antibody, a F(ab) fragment, or a F(ab)2 fragment, for use in the treatment of or in vivo diagnosis of pancreas cancer in a subject, wherein the isolated recombinant antibody or an antigen-binding fragment thereof comprises a light chain variable region that comprises the amino acid sequence of SEQ ID NO:3; and a heavy chain variable region that comprises the amino acid sequence of SEQ ID NO: 6 or a humanized variant of said recombinant antibody or antigen-binding fragment thereof.
A device for vacuuming away drilled material when drilling, with a drill in masonry and similar, having at least one vacuum chamber, at least one suction site spaced apart from the vacuum chamber, a connection fitting for a vacuum unit, which sucks away the drilled material produced at the suction site, and having at least one opening, via which the vacuum chamber is connected in a fluidically manner to the connection fitting, characterized in that at least one relief opening is provided for generating a forced flow in the vacuum chamber to the connection fitting through the opening in a wall of the vacuum chamber, which relief opening connects the vacuum chamber to the environment.
A control device for an internal combustion engine applied to an internal combustion engine of in-cylinder injection type equipped with a fuel injection valve that injects fuel into a combustion chamber, an intake valve provided for the combustion chamber, and a valve system capable of changing an opening timing of the intake valve, a swirl flow being formed in the combustion chamber, characterized in that the control device includes an injection pressure setting part that sets, in a case where the valve system advances the opening timing of the intake vale to thereby strengthen the swirl flow, injection pressure of fuel injected by the fuel injection valve lower than that for a case where the opening time of the intake valve is not advanced. characterized in that the control device includes an injection pressure setting part that sets, in a case where the valve system advances the opening timing of the intake vale to thereby strengthen the swirl flow, injection pressure of fuel injected by the fuel injection valve lower than that for a case where the opening time of the intake valve is not advanced.
A container for receiving and processing fluids, the container comprising: a container housing having a container frame and a plurality of baffles forming a plurality of waffle pockets, the container housing defining an interior space for receiving fluids; a fluid inlet through the container housing for receiving fluids into the interior space; and a liquid-impermeable, vapor-permeable material formed from hydrophilic polymer covering the waffle pockets to form a portion of the container housing that allows egress of evaporated water from the fluids. a container housing having a container frame and a plurality of baffles forming a plurality of waffle pockets, the container housing defining an interior space for receiving fluids; a fluid inlet through the container housing for receiving fluids into the interior space; and a liquid-impermeable, vapor-permeable material formed from hydrophilic polymer covering the waffle pockets to form a portion of the container housing that allows egress of evaporated water from the fluids.
Door leaf in a box-and-cover design, especially a fire protection door leaf, comprising a first and a second metal sheet element (12, 14) each formed of a metal sheet plate which together surround a door leaf cavity, and comprising a filling inserted into said door leaf cavity, wherein rim portions (88, 90; 128, 133) of said metal sheet elements (12, 14) on at least one narrow end face (26, 28, 30, 32) of the door leaf form a lateral cavity (66, 68) extending in the longitudinal direction of the at least one narrow end face (26, 28, 30, 32) and surrounded by said rim portions (88, 90; 128, 133), which lateral cavity is filled by a filling material which is a poorer thermal conductor than said metal sheet, wherein the rim portions of the metal sheet elements (12, 14) surrounding said lateral cavity (66, 68) are indirectly interconnected via said filling material, without directly touching each other, characterized in that the rim portions (88, 90) of the metal sheet elements (12, 14) have mutually complementarily shaped successions of projections (120a, 120b, 121 a, 121 b) and recesses (122a, 122b, 123a, 123b), wherein the projections (120a, 120b) of one metal sheet element engage with the recesses (123a, 123b) of the other metal sheet element in a contact-free and particularly in a spaced-apart manner.
An autonomous cleaner, comprising: a body having a first housing formed at a front of the body and a second housing formed at a rear of the first housing; a brush unit installed at the first housing and configured to sweep and collect dust from a floor; a driving unit, to drive the body, comprising first and second driving wheels (341, 342) provided at lateral side surfaces of the second housing; a dust collecting unit installed at the second housing between the first and second driving wheels, and configured to store the dust collected by the brush unit, the dust collecting device and the driving unit being disposed in a lateral direction of the body; and a power unit installed at the second housing at a rear of the dust collecting unit. a body having a first housing formed at a front of the body and a second housing formed at a rear of the first housing; a brush unit installed at the first housing and configured to sweep and collect dust from a floor; a driving unit, to drive the body, comprising first and second driving wheels (341, 342) provided at lateral side surfaces of the second housing; a dust collecting unit installed at the second housing between the first and second driving wheels, and configured to store the dust collected by the brush unit, the dust collecting device and the driving unit being disposed in a lateral direction of the body; and a power unit installed at the second housing at a rear of the dust collecting unit.
Plant for manufacturing containers from thermoplastic preforms, comprising a protective enclosure intended to isolate an interior volume of the plant from the ambient air contained in an industrial premises in which the plant is installed, the plant comprising, arranged in said interior volume, at least: - a unit for thermally conditioning the preforms which consists of an oven comprising heating means and an air-cooling device which comprises means of filtering the ambient air drawn from the industrial premises by ventilation means in order to cool at least part of the preforms in transit inside the oven using said filtered air; - a unit for converting the preforms into containers, and - a unit for filling the containers obtained from said preforms, characterized in that the plant comprises a cooling-air recycling circuit comprising: - extraction means which are able to extract from the oven the filtered air introduced into the oven by the air-cooling device, and - at least one pipe (62, 74) able to convey at least some of said filtered air extracted from the oven to at least one unit (38, 48) of the plant into which said air is introduced, by means of which all or some of said air filtered initially to perform air-cooling in the oven is recycled at least directly to the conversion unit and/or the filling unit. - a unit for thermally conditioning the preforms which consists of an oven comprising heating means and an air-cooling device which comprises means of filtering the ambient air drawn from the industrial premises by ventilation means in order to cool at least part of the preforms in transit inside the oven using said filtered air; - a unit for converting the preforms into containers, and - a unit for filling the containers obtained from said preforms, - extraction means which are able to extract from the oven the filtered air introduced into the oven by the air-cooling device, and - at least one pipe (62, 74) able to convey at least some of said filtered air extracted from the oven to at least one unit (38, 48) of the plant into which said air is introduced, by means of which all or some of said air filtered initially to perform air-cooling in the oven is recycled at least directly to the conversion unit and/or the filling unit.
A surface working method of a cosmetic make-up product comprising the step of setting the cosmetic make-up product in rotation about an axis of symmetry thereof and, simultaneously, moving a cutting tool above the surface of the cosmetic make-up product on a trajectory lying in a plane containing the axis of symmetry so as to remove at least a part of said surface, thus giving the surface a predetermined shape, characterized in that the make-up product is worked through a turning whereby the make-up product is set in rotation on a first rotating base and the trajectory of the cutting tool is radial with respect to the cosmetic make-up product and with respect to the first rotating base.
A valve actuator comprising: a valve stem; a cartridge with a guide channel; wherein the guide channel has a first end portion and a second end portion, wherein the second end portion of the guide channel is situated opposite the first end portion of the guide channel; a resilient member situated in the guide channel, the valve actuator comprising a seat slidably situated in the guide channel and joined to the resilient member and joined to the valve stem; wherein the resilient member is configured to displace the seat along said guide channel from a first position to a second position; wherein the seat is configured to displace the valve stem along said guide channel from the first position to the second position; the cartridge comprising a first end plate disposed at the first end portion of the guide channel and at least a second end plate (9; 9a) disposed at the second end portion of the guide channel; wherein the cartridge also comprises at least an arcuate arm (8; 8a); wherein the at least a second end plate (9; 9a) is anchored to the guide channel via the at least an arcuate arm (8; 8a); wherein the guide channel is integral with the at least a second end plate (9; 9a) and with the at least an arcuate arm (8; 8a); characterized in that the at least a second end plate (9; 9a) comprises an aperture; and in that the valve stem extends through the aperture of the at least a second end plate (9; 9a); and in that wherein the valve stem comprises a second portion disposed outside the cartridge. a valve stem; a cartridge with a guide channel; wherein the guide channel has a first end portion and a second end portion, wherein the second end portion of the guide channel is situated opposite the first end portion of the guide channel; a resilient member situated in the guide channel, the valve actuator comprising a seat slidably situated in the guide channel and joined to the resilient member and joined to the valve stem; wherein the resilient member is configured to displace the seat along said guide channel from a first position to a second position; wherein the seat is configured to displace the valve stem along said guide channel from the first position to the second position; the cartridge comprising a first end plate disposed at the first end portion of the guide channel and at least a second end plate (9; 9a) disposed at the second end portion of the guide channel; wherein the cartridge also comprises at least an arcuate arm (8; 8a); wherein the at least a second end plate (9; 9a) is anchored to the guide channel via the at least an arcuate arm (8; 8a); wherein the guide channel is integral with the at least a second end plate (9; 9a) and with the at least an arcuate arm (8; 8a); characterized in that the at least a second end plate (9; 9a) comprises an aperture; and in that the valve stem extends through the aperture of the at least a second end plate (9; 9a); and in that wherein the valve stem comprises a second portion disposed outside the cartridge.
A process for making a hot stamped coated steel sheet product, comprising: hot dip pre-coating a steel strip having a first side and a second side with aluminum or aluminum alloy to obtain a pre-coated steel strip, the pre-coating on at least one of said first side and said second side of said strip having a thickness of from 20 to 33 μm at every location on said side of said strip; cutting said pre-coated steel strip to obtain a sheet; heating the sheet in a pre-heated furnace to obtain a heated blank in which the steel is austenitic; transferring said heated blank to a die while maintaining said steel in the austenitic phase; and stamping said heated blank in a die to obtain a hot stamped steel sheet product in which the steel microstructure is martensitic, wherein the steel strip is made of a base steel comprising the following components by weight based on total weight: 0.15%<carbon<0.5% 0.5%<manganese<3% 0.1%<silicon<0.5% 0.01%<chromium<1% titanium<0.2% aluminum<0.1% phosphorus<0.1% 0.0005%<boron<0.08%, 20 ppm or less of sulfur and further comprises iron and impurities inherent in processing. hot dip pre-coating a steel strip having a first side and a second side with aluminum or aluminum alloy to obtain a pre-coated steel strip, the pre-coating on at least one of said first side and said second side of said strip having a thickness of from 20 to 33 μm at every location on said side of said strip; cutting said pre-coated steel strip to obtain a sheet; heating the sheet in a pre-heated furnace to obtain a heated blank in which the steel is austenitic; transferring said heated blank to a die while maintaining said steel in the austenitic phase; and stamping said heated blank in a die to obtain a hot stamped steel sheet product in which the steel microstructure is martensitic, wherein the steel strip is made of a base steel comprising the following components by weight based on total weight: 0.15%<carbon<0.5% 0.5%<manganese<3% 0.1%<silicon<0.5% 0.01%<chromium<1% titanium<0.2% aluminum<0.1% phosphorus<0.1% 0.0005%<boron<0.08%, 20 ppm or less of sulfur 0.15%<carbon<0.5% 0.5%<manganese<3% 0.1%<silicon<0.5% 0.01%<chromium<1% titanium<0.2% aluminum<0.1% phosphorus<0.1% 0.0005%<boron<0.08%, 20 ppm or less of sulfur