A system for calculating the area of a peak profile using information from one or more correlated peak profiles, the system comprising: a separation device that is configured to separate one or more compounds from a mixture over time; a tandem mass spectrometer that is configured to monitor traces of the one or more compounds during the separation, producing a plurality of intensity measurements for the one or more compounds over time; and characterized in that the system further comprises a processor that is configured to: receive the plurality of intensity measurements; detect a first peak profile for a compound of interest from the plurality of intensity measurements for a first trace and detect one or more correlated peak profiles for the compound of interest from the plurality of intensity measurements for one or more other traces, and calculate an area of the first peak profile based on the one or more correlated peak profiles by selecting an initial width and an initial intensity for the first peak profile based on a peak model for the compound of interest, selecting an initial width and an initial intensity for each of the one or more correlated peak profiles based on the peak model, iteratively changing values for position, width, and intensity for the first peak profile and each of the one or more correlated peak profiles until a mathematical optimization criterion is met, and calculating the area of the first peak profile from the last position, width, and intensity of the first peak profile using the peak model. a separation device that is configured to separate one or more compounds from a mixture over time; a tandem mass spectrometer that is configured to monitor traces of the one or more compounds during the separation, producing a plurality of intensity measurements for the one or more compounds over time; and characterized in that the system further comprises a processor that is configured to: receive the plurality of intensity measurements; detect a first peak profile for a compound of interest from the plurality of intensity measurements for a first trace and detect one or more correlated peak profiles for the compound of interest from the plurality of intensity measurements for one or more other traces, and calculate an area of the first peak profile based on the one or more correlated peak profiles by selecting an initial width and an initial intensity for the first peak profile based on a peak model for the compound of interest, selecting an initial width and an initial intensity for each of the one or more correlated peak profiles based on the peak model, iteratively changing values for position, width, and intensity for the first peak profile and each of the one or more correlated peak profiles until a mathematical optimization criterion is met, and calculating the area of the first peak profile from the last position, width, and intensity of the first peak profile using the peak model. receive the plurality of intensity measurements; detect a first peak profile for a compound of interest from the plurality of intensity measurements for a first trace and detect one or more correlated peak profiles for the compound of interest from the plurality of intensity measurements for one or more other traces, and calculate an area of the first peak profile based on the one or more correlated peak profiles by selecting an initial width and an initial intensity for the first peak profile based on a peak model for the compound of interest, selecting an initial width and an initial intensity for each of the one or more correlated peak profiles based on the peak model, iteratively changing values for position, width, and intensity for the first peak profile and each of the one or more correlated peak profiles until a mathematical optimization criterion is met, and calculating the area of the first peak profile from the last position, width, and intensity of the first peak profile using the peak model.