A system for facilitating the detection of an immobilized contrast agent in medical imaging applications, the system including: means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image, wherein the means for reducing includes means for creating a filtered image corresponding to the acquisition instant of each selected input image, wherein the means for creating a filtered image are adapted to create the filtered image by by: defining a set of multiple input images corresponding to the selected input image, the set of multiple input images including the selected input image and consisting of a number of input images lower than the total number, and replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in the set of multiple input images. means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image, wherein the means for reducing includes means for creating a filtered image corresponding to the acquisition instant of each selected input image, wherein the means for creating a filtered image are adapted to create the filtered image by by: defining a set of multiple input images corresponding to the selected input image, the set of multiple input images including the selected input image and consisting of a number of input images lower than the total number, and replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in the set of multiple input images. defining a set of multiple input images corresponding to the selected input image, the set of multiple input images including the selected input image and consisting of a number of input images lower than the total number, and replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in the set of multiple input images.