A compound of Formula (I") or Formula (A"), or a pharmaceutically acceptable form thereof, for use in combination with an immune checkpoint therapy, in a method of treating or preventing a cancer in a subject: wherein: R 1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -COR 2, -COOR 3, or -CONR 4 R 5; z is 0, 1, 2, or 3; each instance of R 3a is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxyl, halogen, cyano, amino, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; B is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -COR 2, -COOR 3, -CONR 4 R 5, or -Si(R 6) 3; wherein R 2, R 3, R 4, R 5, and R 6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 1c is hydrogen, alkyl, alkenyl, or alkynyl; R 2c is hydrogen, alkyl, alkenyl, or alkynyl; W d is heteroaryl, cycloalkyl, heterocycloalkyl, or aryl; and X is CR 1a or N; wherein R 1a is hydrogen, halo, alkyl, alkenyl, alkynyl, or CN; wherein each alkyl, alkenyl, or alkynyl is optionally substituted with one or more halo, OH, alkoxy, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), S 2 (alkyl), cycloalkyl, heterocycloalkyl, aryl or heteroaryl; wherein each cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more halo, alkyl, alkenyl, alkynyl, OH, alkoxy, oxo, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), or S 2 (alkyl); wherein in Formula (I"), when X is CH, B is unsubstituted phenyl, and W d is, then R 1 is not hydrogen, Si(CH 3) 3, CH 2 Si(CH 3) 3, methyl, (CH 2)NH 2, (CH 2) 2 NH 2, (CH 2)NHSO 2 CH 3, or (CH 2) n NHC R 1x; n is 1 or 2; R 1x is methyl, C 2 alkene, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl, where the alkene, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl is optionally substituted with one or two groups independently selected from oxo and cyano; wherein in Formula (A"), when X is CH, B is unsubstituted phenyl, and W d is then R 1 is not phenyl. R 1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -COR 2, -COOR 3, or -CONR 4 R 5; z is 0, 1, 2, or 3; each instance of R 3a is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxyl, halogen, cyano, amino, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; B is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -COR 2, -COOR 3, -CONR 4 R 5, or -Si(R 6) 3; wherein R 2, R 3, R 4, R 5, and R 6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 1c is hydrogen, alkyl, alkenyl, or alkynyl; R 2c is hydrogen, alkyl, alkenyl, or alkynyl; W d is heteroaryl, cycloalkyl, heterocycloalkyl, or aryl; and X is CR 1a or N; wherein R 1a is hydrogen, halo, alkyl, alkenyl, alkynyl, or CN; wherein each alkyl, alkenyl, or alkynyl is optionally substituted with one or more halo, OH, alkoxy, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), S 2 (alkyl), cycloalkyl, heterocycloalkyl, aryl or heteroaryl; wherein each cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more halo, alkyl, alkenyl, alkynyl, OH, alkoxy, oxo, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), or S 2 (alkyl); wherein R 1a is hydrogen, halo, alkyl, alkenyl, alkynyl, or CN; wherein each alkyl, alkenyl, or alkynyl is optionally substituted with one or more halo, OH, alkoxy, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), S 2 (alkyl), cycloalkyl, heterocycloalkyl, aryl or heteroaryl; wherein each cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more halo, alkyl, alkenyl, alkynyl, OH, alkoxy, oxo, NH 2, NH(alkyl), N(alkyl) 2, COH, CO(alkyl), COOH, COO(alkyl), CONH 2, CONH(alkyl), CON(alkyl) 2, S (alkyl), or S 2 (alkyl); wherein in Formula (I"), when X is CH, B is unsubstituted phenyl, and W d is, then R 1 is not hydrogen, Si(CH 3) 3, CH 2 Si(CH 3) 3, methyl, (CH 2)NH 2, (CH 2) 2 NH 2, (CH 2)NHSO 2 CH 3, or (CH 2) n NHC R 1x; n is 1 or 2; R 1x is methyl, C 2 alkene, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl, where the alkene, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl is optionally substituted with one or two groups independently selected from oxo and cyano; wherein in Formula (A"), when X is CH, B is unsubstituted phenyl, and W d is then R 1 is not phenyl.