An isolated compound having the structure: or tautomer thereof; wherein m is 1; A represents (i) phenyl or naphthyl; or (ii) and X is O, S or NR N, wherein R N is hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, -(alkyl)aryl, -(alkyl)heteroaryl, acyl or a nitrogen protecting group; R is one or more substituents selected from the group consisting of hydrogen; halogen; hydroxy; nitro; -CN; aryl; heteroaryl; -C(=O)R a; -NR b R c; -S n R d where n = 0-2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen and C 1-6 alkyl; an optionally substituted fused bicyclic 8-12-membered aromatic or alicyclic ring optionally containing 1-3 heteroatoms selected from the group consisting of N, O, and S; and C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 3-6 cycloalkyl, each independently optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; wherein each occurrence of R a is independently selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, and NR b R c, wherein C 1-6 alkyl and C 1-6 alkoxy are optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; each occurrence of R b and R c is independently selected from the group consisting of hydrogen; hydroxy; SO 2 R d; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro and N(R e) 2; aryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e) 2; and heteroaryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e) 2; each occurrence of R d is independently selected from the group consisting of hydrogen; N(R e) 2; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; aryl and heteroaryl; and each occurrence of R e is independently hydrogen or C 1-6 alkyl; with the proviso that -A-R together is not unsubstituted phenyl, 2,6-dichlorophenyl, 4-methoxyphenyl, 4-diethoxymethylphenyl, or unsubstituted 2-thienyl. wherein m is 1; A represents (i) phenyl or naphthyl; or (ii) and X is O, S or NR N, wherein R N is hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, -(alkyl)aryl, -(alkyl)heteroaryl, acyl or a nitrogen protecting group; R is one or more substituents selected from the group consisting of hydrogen; halogen; hydroxy; nitro; -CN; aryl; heteroaryl; -C(=O)R a; -NR b R c; -S n R d where n = 0-2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen and C 1-6 alkyl; an optionally substituted fused bicyclic 8-12-membered aromatic or alicyclic ring optionally containing 1-3 heteroatoms selected from the group consisting of N, O, and S; and C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 3-6 cycloalkyl, each independently optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; wherein each occurrence of R a is independently selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, aryl, heteroaryl, and NR b R c, wherein C 1-6 alkyl and C 1-6 alkoxy are optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; each occurrence of R b and R c is independently selected from the group consisting of hydrogen; hydroxy; SO 2 R d; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; C 1-6 alkoxy optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro and N(R e) 2; aryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e) 2; and heteroaryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-4 alkyl, C 1-5 alkoxy, nitro, and N(R e) 2; each occurrence of R d is independently selected from the group consisting of hydrogen; N(R e) 2; C 1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, hydroxy, C 1-5 alkoxy, nitro, and N(R e) 2; aryl and heteroaryl; and each occurrence of R e is independently hydrogen or C 1-6 alkyl;