A method for making Rebaudioside M (RebM), comprising: providing a host cell producing RebM from steviol, the host cell expressing uridine diphosphate-dependent glycosyltransferase enzymes that catalyze C13- O glycosylation of steviol, C19- O glycosylation of steviol, 1-2' glycosylation at C13 and C19 of steviol, and 1-3' glycosylation at C13 and C19 of steviol, the UGT enzymes comprising one or more of: (a) a UGT enzyme having 1-2' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 45 and has an increase in 1-2' glycosylating activity at C19 of Rebaudioside A (RebA) as compared to the UGT enzyme of SEQ ID NO: 7, without substantial loss of 1-2' glycosylating activity at C13 of steviolmonoside; (b) a UGT enzyme having 1-3' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 3, has a mutation selected from L200A or L200G with respect to SEQ ID NO: 3, and has an increase in 1-3' glycosylating activity at C19 of Rebaudioside D (RebD) as compared to the UGT enzyme of SEQ ID NO: 3, without substantial loss of 1-3' glycosylating activity at C13 of stevioside; and (c) a UGT enzyme having C13- O glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 1, comprises a P215T substitution with respect to SEQ ID NO: 1, and has an increased activity for converting steviol to steviolmonoside as compared to the UGT enzyme of SEQ ID NO: 1; and culturing the host cell under conditions for producing the RebM; and recovering RebM from the culture. providing a host cell producing RebM from steviol, the host cell expressing uridine diphosphate-dependent glycosyltransferase enzymes that catalyze C13- O glycosylation of steviol, C19- O glycosylation of steviol, 1-2' glycosylation at C13 and C19 of steviol, and 1-3' glycosylation at C13 and C19 of steviol, the UGT enzymes comprising one or more of: (a) a UGT enzyme having 1-2' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 45 and has an increase in 1-2' glycosylating activity at C19 of Rebaudioside A (RebA) as compared to the UGT enzyme of SEQ ID NO: 7, without substantial loss of 1-2' glycosylating activity at C13 of steviolmonoside; (b) a UGT enzyme having 1-3' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 3, has a mutation selected from L200A or L200G with respect to SEQ ID NO: 3, and has an increase in 1-3' glycosylating activity at C19 of Rebaudioside D (RebD) as compared to the UGT enzyme of SEQ ID NO: 3, without substantial loss of 1-3' glycosylating activity at C13 of stevioside; and (c) a UGT enzyme having C13- O glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 1, comprises a P215T substitution with respect to SEQ ID NO: 1, and has an increased activity for converting steviol to steviolmonoside as compared to the UGT enzyme of SEQ ID NO: 1; and (a) a UGT enzyme having 1-2' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 45 and has an increase in 1-2' glycosylating activity at C19 of Rebaudioside A (RebA) as compared to the UGT enzyme of SEQ ID NO: 7, without substantial loss of 1-2' glycosylating activity at C13 of steviolmonoside; (b) a UGT enzyme having 1-3' glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 3, has a mutation selected from L200A or L200G with respect to SEQ ID NO: 3, and has an increase in 1-3' glycosylating activity at C19 of Rebaudioside D (RebD) as compared to the UGT enzyme of SEQ ID NO: 3, without substantial loss of 1-3' glycosylating activity at C13 of stevioside; and (c) a UGT enzyme having C13- O glycosylating activity, which comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 1, comprises a P215T substitution with respect to SEQ ID NO: 1, and has an increased activity for converting steviol to steviolmonoside as compared to the UGT enzyme of SEQ ID NO: 1; and culturing the host cell under conditions for producing the RebM; and recovering RebM from the culture.