mhurhangee/ep-ind-claims huggingface dataset:
A combined coaxial and bimanual irrigation/aspiration assembly for use in a surgical procedure, comprising: an irrigation hand piece including an irrigation needle extending from a distal end of the irrigation hand piece, the irrigation needle configured to release an irrigation fluid from the assembly; an aspiration hand piece including an aspiration needle extending from a distal end of the aspiration hand piece, the aspiration needle having an axis and being configured to aspirate a fluid into the assembly, characterised in that the assembly further comprises a sleeve member, the sleeve member coupling the irrigation hand piece and the aspiration hand piece together when the assembly is in a first configuration wherein the sleeve member has an internal bore and the distal ends (112,126) of the aspiration and irrigation hand pieces are configured to extend into the bore to couple the distal ends of the aspiration and irrigation hand pieces to the sleeve member; wherein the assembly has a first configuration in which the irrigation hand piece and aspiration hand piece are coupled together such that the aspiration needle extends along a central axis of the sleeve member in the first configuration within the internal bore, whereby irrigation fluid emitted from the irrigation needle is delivered through an annular space between the aspiration needle and the sleeve member along the distal end of the sleeve member and a second disassembled configuration which provides physically separable and independently operable irrigation hand piece and aspiration hand piece that act as a bimanual instrument. an irrigation hand piece including an irrigation needle extending from a distal end of the irrigation hand piece, the irrigation needle configured to release an irrigation fluid from the assembly; an aspiration hand piece including an aspiration needle extending from a distal end of the aspiration hand piece, the aspiration needle having an axis and being configured to aspirate a fluid into the assembly, characterised in that the assembly further comprises a sleeve member, the sleeve member coupling the irrigation hand piece and the aspiration hand piece together when the assembly is in a first configuration wherein the sleeve member has an internal bore and the distal ends (112,126) of the aspiration and irrigation hand pieces are configured to extend into the bore to couple the distal ends of the aspiration and irrigation hand pieces to the sleeve member; wherein the assembly has a first configuration in which the irrigation hand piece and aspiration hand piece are coupled together such that the aspiration needle extends along a central axis of the sleeve member in the first configuration within the internal bore, whereby irrigation fluid emitted from the irrigation needle is delivered through an annular space between the aspiration needle and the sleeve member along the distal end of the sleeve member and a second disassembled configuration which provides physically separable and independently operable irrigation hand piece and aspiration hand piece that act as a bimanual instrument.
A disabling system for a syringe, said disabling system comprising a plunger having ratchets (23A, 23B) and a collar mountable to a barrel of said syringe, wherein each ratchet (23A, 23B) comprises a plurality of steps (24A, 24B), said steps comprising deep shoulders (26A, 26B) and shallow shoulders (27A, 27B), said collar comprising an inner member and an outer member having resiliently deformable pawls (42A, 42B) capable of engaging said corresponding ratchets (23A, 23B) when in a non-deformed position, said inner member comprising an inner member body having a first projection and a second projection, which projections (52A, 52B) are resiliently deformable, whereby in a deformed position said resiliently deformable pawls (42A, 42B) exert an inward pressure on projections (52A, 52B) thereby clamping said projections (52A, 52B) in a deformed position to prevent engagement of said ratchets (23A, 23B) by said pawls (42A, 42B) until said plunger is depressed so that it pushes the shallow shoulders (27A, 27B) of the steps (24A, 24B) against said projections (52A, 52B), thereby forcing the inner member out of its initial position engaged with the outer member to thereby expose the pawls (42A, 42B) such that said projections (52A, 52B) return to a non-deformed position which allows said pawls (42A, 42B) to adopt the non-deformed position and can engage said corresponding ratchets (23A, 23B) to prevent withdrawal of said plunger and syringe re-use.
A teeth aligner system providing orthodontic tooth movement for use in assisting corrective realignment of a patient's teeth, the aligner system including: a. a removable thermoplastic aligner having a teeth-receiving cavity with a teeth-aligning surface formed as an inner surface of the teeth-receiving cavity; b. a substantially transparent force transfer layer formed on the teeth aligning surface comprising a curable gel engaging between the teeth aligning surface and the patient's teeth, enabling substantially a separation and spacing of the aligner from the teeth while providing a force transfer mechanism from the removable thermoplastic aligner to the teeth when located in a required OTM fitting position on the teeth of the patient to provide an effective OTM force on the teeth; c. wherein the curable gel and the thermoplastic of the aligner are selected to provide a comparative differential of adhesion bond between the cured gel and thermoplastic aligner and the cured gel and the patient's teeth allowing ready removal of the aligner without damage to the teeth and ready repositioning to the OTM fitting position; d. wherein the inner surface of the teeth-receiving cavity is textured, and wherein the inner surface of the gel layer and the textured surface portion of the aligner forms a mechanical and/or adhesive bond upon cross linking of the gel by curing of the gel and interconnecting with the textured surface. a. a removable thermoplastic aligner having a teeth-receiving cavity with a teeth-aligning surface formed as an inner surface of the teeth-receiving cavity; b. a substantially transparent force transfer layer formed on the teeth aligning surface comprising a curable gel engaging between the teeth aligning surface and the patient's teeth, enabling substantially a separation and spacing of the aligner from the teeth while providing a force transfer mechanism from the removable thermoplastic aligner to the teeth when located in a required OTM fitting position on the teeth of the patient to provide an effective OTM force on the teeth; c. wherein the curable gel and the thermoplastic of the aligner are selected to provide a comparative differential of adhesion bond between the cured gel and thermoplastic aligner and the cured gel and the patient's teeth allowing ready removal of the aligner without damage to the teeth and ready repositioning to the OTM fitting position; d. wherein the inner surface of the teeth-receiving cavity is textured, and wherein the inner surface of the gel layer and the textured surface portion of the aligner forms a mechanical and/or adhesive bond upon cross linking of the gel by curing of the gel and interconnecting with the textured surface.
A compound of formula wherein 'A' is selected from unsubstituted or substituted aryl, or heterocyclyl groups having one or more than one heteroatoms; 'B-(R 2) m ' is wherein X, Y, Z at each occurrence is independently selected from C, N, S, SOz, and O, which may be optionally substituted; R 1 represents one or more substituents selected from hydrogen, halogen, cyano, optionally substituted groups selected from (C 1 -C 6)alkyl preferably haloalkyl, (C 2 -Cs)alkenyl, (C 1 -C 6)alkoxy, (C 3 -C 6)cycloalkyl, aryl, heterocyclyl preferably heteroaryl, benzyl, thiol, mercapto alkyl, C 1 -C 6 (thio-alkoxy), bridged or spiro ring system having optionally one or more than one heteroatoms; R 3 represents cyano; 'n' is 0-3; R 4 is selected from hydrogen, and optionally substituted groups selected from (C 1 -Cs)alkyl; wherein the substituents on any of the optionally substituted groups above are independently selected from hydrogen, hydroxy, cyano, halo, haloalkyl, haloalkyloxy, alkylthio (C 1 -C 6)alkyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 3 -C 10)cycloalkyl, (C 1 -C 6)alkoxy, -COR 10, -CSR 10, C OR 10, C -R 10, -C -NR 11 R 12, -C -NR 11 R 12, -SO 2 R 10 group, wherein R 10 is independently selected from hydrogen, optionally substituted group selected from (C 1 -C 6)alkyl, (C 2 -Cs)alkenyl, (C 2 -C 6)alkynyl, (C 3 -C 7)cycloalkyl, aryl, and heterocyclyl group, preferably heteroaryl; R 11 and R 12 are independently selected from hydrogen, optionally substituted group selected from (C 1 -C 6)alkyl, (C 1 - Cs)alkoxy, aryl or benzyl group. 'A' is selected from unsubstituted or substituted aryl, or heterocyclyl groups having one or more than one heteroatoms; 'B-(R 2) m ' is wherein X, Y, Z at each occurrence is independently selected from C, N, S, SOz, and O, which may be optionally substituted; R 1 represents one or more substituents selected from hydrogen, halogen, cyano, optionally substituted groups selected from (C 1 -C 6)alkyl preferably haloalkyl, (C 2 -Cs)alkenyl, (C 1 -C 6)alkoxy, (C 3 -C 6)cycloalkyl, aryl, heterocyclyl preferably heteroaryl, benzyl, thiol, mercapto alkyl, C 1 -C 6 (thio-alkoxy), bridged or spiro ring system having optionally one or more than one heteroatoms; R 3 represents cyano; 'n' is 0-3; R 4 is selected from hydrogen, and optionally substituted groups selected from (C 1 -Cs)alkyl; wherein the substituents on any of the optionally substituted groups above are independently selected from hydrogen, hydroxy, cyano, halo, haloalkyl, haloalkyloxy, alkylthio (C 1 -C 6)alkyl, (C 2 -C 6)alkenyl, (C 2 -C 6)alkynyl, (C 3 -C 10)cycloalkyl, (C 1 -C 6)alkoxy, -COR 10, -CSR 10, C OR 10, C -R 10, -C -NR 11 R 12, -C -NR 11 R 12, -SO 2 R 10 group, wherein R 10 is independently selected from hydrogen, optionally substituted group selected from (C 1 -C 6)alkyl, (C 2 -Cs)alkenyl, (C 2 -C 6)alkynyl, (C 3 -C 7)cycloalkyl, aryl, and heterocyclyl group, preferably heteroaryl; R 11 and R 12 are independently selected from hydrogen, optionally substituted group selected from (C 1 -C 6)alkyl, (C 1 - Cs)alkoxy, aryl or benzyl group.
Catheter for the transfer of human embryos, wherein the catheter comprises an outer, harder catheter (α) and an inner, soft catheter (β), characterized in that outer catheter (α) has element of transverse folds in the shape of an "accordion". such as w hen being compact, the element of transverse folds is 1 cm long while the distance of its center from the tip of the catheter is 5.5 cm but can vary +/- 1 cm in variations of the same design.
Handle arrangement for a window, door or the like which has at least one frame profile having a front face and side face and which is provided with glazing, the side face bordering on the glazing at an angle, comprising a handle which can be handled manually and which passes through a handle movement when handled, and comprising a cover, characterised in that the cover is formed as a corner cap comprising an upper face, which is parallel to, in particular flush with, the front face, and an end face, which is parallel to, in particular flush with, the side face, and in that a clearance which permits the handle movement is provided on the end face of the corner cap.
Microorganism of the species Corynebacterium glutamicum that produces and/or secretes an organochemical compound, characterized in that the microorganism an increased expression, compared to the particular starting strain, of a polynucleotide coding for a polypeptide having an amino acid sequence which has an identity of 70% or more in relation to the amino acid sequence shown in SEQ ID NO: 8 or 20, wherein the increased expression of the polynucleotide is increased by one or more measures selected from the following group: a) the expression of the gene is under the control of a promoter which is stronger in the microorganism used for the method than the original promoter of the gene; b) increasing the copy number of the gene coding for a polypeptide having the activity of a trehalose importer; preferably by insertion of the gene in plasmids with increased copy number and/or by integration of the gene into the chromosome of the microorganism in at least one copy; c) the expression of the gene is achieved with use of a ribosome binding site which is stronger in the microorganism used for the method than the original ribosome binding site of the gene; d) the expression of the gene is achieved with optimization of the codon usage of the microorganism used for the method; e) the expression of the gene is achieved with reduction of mRNA secondary structures in the mRNA transcribed from the gene; f) the expression of the gene is achieved with elimination of RNA polymerase terminators in the mRNA transcribed from the gene; g) the expression of the gene is achieved with use of mRNA-stabilizing sequences in the mRNA transcribed from the gene; and wherein said polypeptide, which is a subunit of a protein complex having the activity of a trehalose importer, has the activity of a permease and wherein the microorganism is capable of taking up trehalose from the medium. a) the expression of the gene is under the control of a promoter which is stronger in the microorganism used for the method than the original promoter of the gene; b) increasing the copy number of the gene coding for a polypeptide having the activity of a trehalose importer; preferably by insertion of the gene in plasmids with increased copy number and/or by integration of the gene into the chromosome of the microorganism in at least one copy; c) the expression of the gene is achieved with use of a ribosome binding site which is stronger in the microorganism used for the method than the original ribosome binding site of the gene; d) the expression of the gene is achieved with optimization of the codon usage of the microorganism used for the method; e) the expression of the gene is achieved with reduction of mRNA secondary structures in the mRNA transcribed from the gene; f) the expression of the gene is achieved with elimination of RNA polymerase terminators in the mRNA transcribed from the gene; g) the expression of the gene is achieved with use of mRNA-stabilizing sequences in the mRNA transcribed from the gene;
Method for the production of a three-dimensional porous structure made of fragments which consist of a web made of nanofibres, comprising a) cutting a dry or wet web made of nanofibres into fragments with a laser and suspending the web fragments in a liquid medium; or b) cutting a web made of nanofibres which is present in a liquid medium into fragments with a laser, as a result of which a suspension of web fragments in the liquid medium is produced; and c) at least partial removal of the liquid medium, a three-dimensional, porous structure being formed from web fragments by means of self-organisation. a) cutting a dry or wet web made of nanofibres into fragments with a laser and suspending the web fragments in a liquid medium; or b) cutting a web made of nanofibres which is present in a liquid medium into fragments with a laser, as a result of which a suspension of web fragments in the liquid medium is produced; and c) at least partial removal of the liquid medium, a three-dimensional, porous structure being formed from web fragments by means of self-organisation.
Musical watch case including at least one cover assembly, which includes on the one hand a bezel, and on the other at least one crystal or one case back, a casing ring, a case middle which has a first surface for receiving and supporting said cover assembly and a median surface for receiving and supporting said casing ring, said case including at least one gong integral with said case middle and including a resonant part distinct from the walls of said case middle, wherein said case middle supports said cover assembly via at least one lug comprised in said bezel and which is arranged to allow said cover assembly to vibrate and radiate at frequencies comprised between 4 kHz and 6 kHz, each said lug being distinct from every other said lug and having no contact with any other said lug, characterized in that said case middle includes, around a substantially annular, peripheral wall defining an inner chamber extending around said casing ring, and around all of said lugs comprised in said case, a resonator ring placed on said case middle or forming a lip of said case middle, said resonator ring being distant at all points from said bezel and from said lugs, and forming with said peripheral wall an outer radiating cavity.
Battlefield illumination module to be arranged in the area of a barrel of a handgun, wherein the battlefield illumination module has a light source, characterized in that the light source comprises a primary light source which is designed to be extendable from a rest position to a working position.
A washing machine, comprising: a casing forming an exterior; a tub disposed within the casing; a drum rotatably provided in the tub, for accommodating a laundry; and a water supply distributor disposed within the casing and comprising a temporary space in which externally introduced water gathers, a plurality of discharge ports for distributing the water of the temporary space toward a plurality of points, and a pressure limit unit for limiting an increase of water pressure within the temporary space, characterized in that the water supply distributor comprises: a flow channel switching plate of a disk shape in which an open hole is formed; and a housing into which the flow channel switching plate is rotatably inserted and in which a flow channel for communicating the open hole with the discharge ports is formed when the flow channel switching plate is rotated, and further comprises a flow channel forming plate in which a plurality of discharge holes is formed so that the flow channel communicates with the open hole, wherein the pressure limit unit is formed to discharge the water gathered in the temporary space when the flow channel switching plate is disposed so that the open hole and the discharge holes do not communicate with each other. a casing forming an exterior; a tub disposed within the casing; a drum rotatably provided in the tub, for accommodating a laundry; and a water supply distributor disposed within the casing and comprising a temporary space in which externally introduced water gathers, a plurality of discharge ports for distributing the water of the temporary space toward a plurality of points, and a pressure limit unit for limiting an increase of water pressure within the temporary space, characterized in that the water supply distributor comprises: a flow channel switching plate of a disk shape in which an open hole is formed; and a housing into which the flow channel switching plate is rotatably inserted and in which a flow channel for communicating the open hole with the discharge ports is formed when the flow channel switching plate is rotated, and further comprises a flow channel forming plate in which a plurality of discharge holes is formed so that the flow channel communicates with the open hole, wherein the pressure limit unit is formed to discharge the water gathered in the temporary space when the flow channel switching plate is disposed so that the open hole and the discharge holes do not communicate with each other. a flow channel switching plate of a disk shape in which an open hole is formed; and a housing into which the flow channel switching plate is rotatably inserted and in which a flow channel for communicating the open hole with the discharge ports is formed when the flow channel switching plate is rotated, and further comprises a flow channel forming plate in which a plurality of discharge holes is formed so that the flow channel communicates with the open hole, wherein the pressure limit unit is formed to discharge the water gathered in the temporary space when the flow channel switching plate is disposed so that the open hole and the discharge holes do not communicate with each other.
A composition comprising a fenamate or a prodrug thereof, said composition for use in therapeutically treating or preventing one or more indicators or symptoms associated with autism or an autism spectrum disorder in a human subject, wherein the fenamate is selected from the group consisting of fenamic acid, mefenamic acid, niflumic acid, tolfenamic acid, and meclofenamic acid, and wherein the prodrug comprises the fenamate: (a) covalently bound to polyethylene glycol; (b) directly bound or bound by a linker to the same fenamate molecule; (c) directly bound or bound by a linker to a different fenamate molecule; or (d) directly bound or bound by a linker to a calcium channel modulator selected from gabapentin, pregabalin, or atagabalin. (a) covalently bound to polyethylene glycol; (b) directly bound or bound by a linker to the same fenamate molecule; (c) directly bound or bound by a linker to a different fenamate molecule; or (d) directly bound or bound by a linker to a calcium channel modulator selected from gabapentin, pregabalin, or atagabalin.
A medical elongated body comprising: a catheter main body comprising a lumen, a tubular body, and a distal member at a distal end of the tubular body, the distal member being more flexible than the tubular body, the tubular body extending in an axial direction, the distal member being formed from a distal member material; the distal end of the tubular body being joined to the distal member at a joint portion; the tubular body comprising an outer layer and an inner layer disposed radially inside the outer layer, the outer layer being formed from an outer layer material and the inner layer being formed from an inner layer material; and the inner layer being interposed between the distal member and the outer layer by extending radially outwardly between the distal member and the outer layer at the joint portion, characterized in that the inner layer material possesses better fusing properties with respect to the distal member material than the fusing properties of the outer layer material with respect to the distal member material. a catheter main body comprising a lumen, a tubular body, and a distal member at a distal end of the tubular body, the distal member being more flexible than the tubular body, the tubular body extending in an axial direction, the distal member being formed from a distal member material; the distal end of the tubular body being joined to the distal member at a joint portion; the tubular body comprising an outer layer and an inner layer disposed radially inside the outer layer, the outer layer being formed from an outer layer material and the inner layer being formed from an inner layer material; and the inner layer being interposed between the distal member and the outer layer by extending radially outwardly between the distal member and the outer layer at the joint portion, characterized in that the inner layer material possesses better fusing properties with respect to the distal member material than the fusing properties of the outer layer material with respect to the distal member material.