Device for shutting off a pipe, said pipe allowing fluidic circulation of at least one fluid, said shut-off device comprising: • an in-line shut-off means for shutting off said pipe in a sealed manner and, conversely, for opening said pipe, said in-line shut-off means comprising a plate and tightening means allowing said plate to be tightened and, conversely, released, in order to allow said plate to be moved relative to said pipe, said plate being able to be moved depending on the positioning of a tightening control member; • an upstream valve arranged upstream of said in-line shut-off means, said upstream valve being able to be actuated between an open position allowing said fluidic circulation and a closed position preventing said fluidic circulation, said upstream valve being actuated manually by an operator by means of an upstream control member, • a downstream valve arranged downstream of said in-line shut-off means, said downstream valve being able to be actuated between an open position allowing the fluidic circulation and a closed position preventing the fluidic circulation, said downstream valve being actuated manually by an operator by means of a downstream control member, said shut-off device comprising an interlocking system for interlocking said tightening control member with said upstream control member and said downstream control member, said interlocking system being movable in translation in a direction OX between a first end position and a second end position, said interlocking system comprising different portions (p1-p6) such that: ∘ in said first end position, a first portion allows the manual actuation of said upstream control member, a second portion allows the manual actuation of said downstream control member and a third portion prevents the manual actuation of said tightening control member; ∘ in said second end position, a fourth portion prevents the manual actuation of said upstream control member, a fifth portion prevents the manual actuation of said downstream control member and a sixth portion allows the manual actuation of said tightening control member, characterised in that said interlocking system comprises at least three separate parts (31, 32, 33) assembled together, said at least three parts (31, 32, 33) comprising a first part comprising said first portion and said fourth portion, a second part comprising said third portion and said sixth portion, and a third part comprising said second portion and said fifth portion. • an in-line shut-off means for shutting off said pipe in a sealed manner and, conversely, for opening said pipe, said in-line shut-off means comprising a plate and tightening means allowing said plate to be tightened and, conversely, released, in order to allow said plate to be moved relative to said pipe, said plate being able to be moved depending on the positioning of a tightening control member; • an upstream valve arranged upstream of said in-line shut-off means, said upstream valve being able to be actuated between an open position allowing said fluidic circulation and a closed position preventing said fluidic circulation, said upstream valve being actuated manually by an operator by means of an upstream control member, • a downstream valve arranged downstream of said in-line shut-off means, said downstream valve being able to be actuated between an open position allowing the fluidic circulation and a closed position preventing the fluidic circulation, said downstream valve being actuated manually by an operator by means of a downstream control member, said shut-off device comprising an interlocking system for interlocking said tightening control member with said upstream control member and said downstream control member, said interlocking system being movable in translation in a direction OX between a first end position and a second end position, said interlocking system comprising different portions (p1-p6) such that: ∘ in said first end position, a first portion allows the manual actuation of said upstream control member, a second portion allows the manual actuation of said downstream control member and a third portion prevents the manual actuation of said tightening control member; ∘ in said second end position, a fourth portion prevents the manual actuation of said upstream control member, a fifth portion prevents the manual actuation of said downstream control member and a sixth portion allows the manual actuation of said tightening control member, ∘ in said first end position, a first portion allows the manual actuation of said upstream control member, a second portion allows the manual actuation of said downstream control member and a third portion prevents the manual actuation of said tightening control member; ∘ in said second end position, a fourth portion prevents the manual actuation of said upstream control member, a fifth portion prevents the manual actuation of said downstream control member and a sixth portion allows the manual actuation of said tightening control member, characterised in that said interlocking system comprises at least three separate parts (31, 32, 33) assembled together, said at least three parts (31, 32, 33) comprising a first part comprising said first portion and said fourth portion, a second part comprising said third portion and said sixth portion, and a third part comprising said second portion and said fifth portion.