A hypotension prediction software code including a predictive weighting module, which when executed by a hardware processor (104, 304), cause the hardware processor to instantiate a method comprising: obtaining a digital hemodynamic data (144, 244) converted, by an analog-to-digital converter (ADC, 122, 222), from a signal (142, 242) received from the hemodynamic sensor (140, 240a, 240b); obtaining one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data (144, 244), the one or more vital sign parameters including a mean arterial pressure, MAP, of the living subject; deriving differential parameters based on the one or more vital sign parameters characterizing vital sign data; generating, by the hypotension prediction software code (110, 210, 310) executed by the hardware processor (104, 304), combinatorial parameters using the one or more vital sign parameters characterizing vital sign data and the differential parameters; determining, using the predictive weighting module, a risk score corresponding to the probability of a future hypotension event for a living subject (130, 230) based on a weighted combination of a plurality of hypotension profiling parameters (112, 212) including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters; and invoking a sensory alarm if the risk score satisfies a predetermined risk criterion, wherein the weighted combination of the plurality of hypotension profiling parameters (112, 212) results in the MAP being substantially disregarded in determination of the risk score, or wherein the weighted combination of the plurality of hypotension profiling parameters (112, 212) results in the MAP substantially dominating determination of the risk score. obtaining a digital hemodynamic data (144, 244) converted, by an analog-to-digital converter (ADC, 122, 222), from a signal (142, 242) received from the hemodynamic sensor (140, 240a, 240b); obtaining one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data (144, 244), the one or more vital sign parameters including a mean arterial pressure, MAP, of the living subject; deriving differential parameters based on the one or more vital sign parameters characterizing vital sign data; generating, by the hypotension prediction software code (110, 210, 310) executed by the hardware processor (104, 304), combinatorial parameters using the one or more vital sign parameters characterizing vital sign data and the differential parameters; determining, using the predictive weighting module, a risk score corresponding to the probability of a future hypotension event for a living subject (130, 230) based on a weighted combination of a plurality of hypotension profiling parameters (112, 212) including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters; and invoking a sensory alarm if the risk score satisfies a predetermined risk criterion, wherein the weighted combination of the plurality of hypotension profiling parameters (112, 212) results in the MAP being substantially disregarded in determination of the risk score, or wherein the weighted combination of the plurality of hypotension profiling parameters (112, 212) results in the MAP substantially dominating determination of the risk score.