A method for analysing a sample comprising nucleic acids, comprising the following steps: A a) lysing the sample to release nucleic acids from cells to provide a lysed sample and clearing the lysed sample, wherein clearing of the lysed sample involves contacting the sample prior, during or after lysis with at least one solid support which binds to contaminants originating from the lysed sample, wherein the solid support is magnetic particles and comprises carboxyl groups on its surface; b) contacting at least a portion of the cleared lysed sample with a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the cleared lysed sample; c) performing an analytical method using the reconstituted composition; wherein lysis of the sample comprises the addition of a lysis solution comprising (i) at least one non-ionic surfactant or mixture of non-ionic detergents and (ii) at least one polymer selected from polyvinylpyrrolidone, polyoxazoline, polyethylene glycol and polyvinyl alcohol; or B a) contacting the sample with a lysis solution to release nucleic acids from cells thereby providing a lysis mixture, wherein the lysis solution comprises (i) at least one non-ionic surfactant or mixture of non-ionic detergents and (ii) at least one polymer selected from polyvinylpyrrolidone, polyoxazoline, polyethylene glycol and polyvinyl alcohol; b) using the lysis mixture to reconstitute a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the lysis mixture; c) performing an analytical method using the reconstituted composition, wherein the reconstituted composition is cleared and wherein subsequent to step b) at least one step is performed which supports the lysis of the sample, wherein clearing of the reconstituted composition involves contacting the sample prior, during or after lysis with at least one solid support which binds to contaminants originating from the lysed sample, wherein the solid support is magnetic particles and comprises carboxyl groups on its surface. A a) lysing the sample to release nucleic acids from cells to provide a lysed sample and clearing the lysed sample, wherein clearing of the lysed sample involves contacting the sample prior, during or after lysis with at least one solid support which binds to contaminants originating from the lysed sample, wherein the solid support is magnetic particles and comprises carboxyl groups on its surface; b) contacting at least a portion of the cleared lysed sample with a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the cleared lysed sample; c) performing an analytical method using the reconstituted composition; wherein lysis of the sample comprises the addition of a lysis solution comprising (i) at least one non-ionic surfactant or mixture of non-ionic detergents and (ii) at least one polymer selected from polyvinylpyrrolidone, polyoxazoline, polyethylene glycol and polyvinyl alcohol; or a) lysing the sample to release nucleic acids from cells to provide a lysed sample and clearing the lysed sample, wherein clearing of the lysed sample involves contacting the sample prior, during or after lysis with at least one solid support which binds to contaminants originating from the lysed sample, wherein the solid support is magnetic particles and comprises carboxyl groups on its surface; b) contacting at least a portion of the cleared lysed sample with a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the cleared lysed sample; c) performing an analytical method using the reconstituted composition; B a) contacting the sample with a lysis solution to release nucleic acids from cells thereby providing a lysis mixture, wherein the lysis solution comprises (i) at least one non-ionic surfactant or mixture of non-ionic detergents and (ii) at least one polymer selected from polyvinylpyrrolidone, polyoxazoline, polyethylene glycol and polyvinyl alcohol; b) using the lysis mixture to reconstitute a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the lysis mixture; c) performing an analytical method using the reconstituted composition, a) contacting the sample with a lysis solution to release nucleic acids from cells thereby providing a lysis mixture, wherein the lysis solution comprises (i) at least one non-ionic surfactant or mixture of non-ionic detergents and (ii) at least one polymer selected from polyvinylpyrrolidone, polyoxazoline, polyethylene glycol and polyvinyl alcohol; b) using the lysis mixture to reconstitute a dry composition, which is a freeze-dried composition, comprising reagents for performing the analytical method, thereby providing a reconstituted composition, wherein reconstitution is exclusively achieved by addition of the lysis mixture; c) performing an analytical method using the reconstituted composition,