An analyte detection system for the detection and measurement of various analytes which are present in a patient's liquid test sample, comprising: a base, the base comprising at least one side, a top surface, and a bottom surface, the base further comprising: a liquid test sample inlet for receiving a patient's liquid test sample, the liquid test sample inlet being located on the top portion of the base; a plurality of microchannels located within the base and in fluid communication with the liquid test sample inlet, the plurality of microchannels being located between the top surface and bottom surface of the base; an electrochemical assay portion; and a CO-oximetry assay portion, the CO-oximetry assay portion comprising: a CO-oximetry sensor module, the CO-oximetry sensor module comprising a sample holder configured to hold a volume of the patient's liquid test sample, the sample holder further comprising an optical measurement surface; the CO-oximetry assay portion further comprising a shunt configured to slice the patient's liquid test sample to a predetermined thickness and transfer the thinned sample to the optical measurement surface, wherein the predetermined thickness is in a range of from about 80 microns to about 160 microns; and wherein the electrochemical assay portion and the CO-oximetry assay portion are in fluid communication with and connected via the plurality of microchannels. a base, the base comprising at least one side, a top surface, and a bottom surface, the base further comprising: a liquid test sample inlet for receiving a patient's liquid test sample, the liquid test sample inlet being located on the top portion of the base; a plurality of microchannels located within the base and in fluid communication with the liquid test sample inlet, the plurality of microchannels being located between the top surface and bottom surface of the base; an electrochemical assay portion; and a CO-oximetry assay portion, the CO-oximetry assay portion comprising: a CO-oximetry sensor module, the CO-oximetry sensor module comprising a sample holder configured to hold a volume of the patient's liquid test sample, the sample holder further comprising an optical measurement surface; the CO-oximetry assay portion further comprising a shunt configured to slice the patient's liquid test sample to a predetermined thickness and transfer the thinned sample to the optical measurement surface, wherein the predetermined thickness is in a range of from about 80 microns to about 160 microns; and wherein the electrochemical assay portion and the CO-oximetry assay portion are in fluid communication with and connected via the plurality of microchannels. a liquid test sample inlet for receiving a patient's liquid test sample, the liquid test sample inlet being located on the top portion of the base; a plurality of microchannels located within the base and in fluid communication with the liquid test sample inlet, the plurality of microchannels being located between the top surface and bottom surface of the base; an electrochemical assay portion; and a CO-oximetry assay portion, the CO-oximetry assay portion comprising: a CO-oximetry sensor module, the CO-oximetry sensor module comprising a sample holder configured to hold a volume of the patient's liquid test sample, the sample holder further comprising an optical measurement surface; the CO-oximetry assay portion further comprising a shunt configured to slice the patient's liquid test sample to a predetermined thickness and transfer the thinned sample to the optical measurement surface, wherein the predetermined thickness is in a range of from about 80 microns to about 160 microns; and wherein the electrochemical assay portion and the CO-oximetry assay portion are in fluid communication with and connected via the plurality of microchannels. a CO-oximetry sensor module, the CO-oximetry sensor module comprising a sample holder configured to hold a volume of the patient's liquid test sample, the sample holder further comprising an optical measurement surface; the CO-oximetry assay portion further comprising a shunt configured to slice the patient's liquid test sample to a predetermined thickness and transfer the thinned sample to the optical measurement surface, wherein the predetermined thickness is in a range of from about 80 microns to about 160 microns; and wherein the electrochemical assay portion and the CO-oximetry assay portion are in fluid communication with and connected via the plurality of microchannels.