A method comprising: determining, at one or more small cell radios (114a-114b): user equipment, UE, (112a-112d) path loss information between one or more UE (112a-112d) served by one or more small cell radios (114a-114b) and the one or more small radio cells (114a-114b); and macro path loss information from a macro cell radio to each of the one or more small cell radios (114a-114b); the method further comprising: determining, at a central management entity, one or more sets of optimized power control parameters for uplink UE transmissions for the one or more UE (112a-112d) served by the one or more small cell radios (114a-114b), wherein the one or more sets of optimized power control parameters satisfy a first interference constraint associated with limiting interference between the one or more small cell radios and satisfy a second interference constraint associated with limiting interference toward the macro cell radio, wherein determining the one or more sets of optimized power control parameters further comprises: calculating, at the central management entity, one or more sets of candidate power control parameters that meet the first interference constraint for one or more Signal to Interference plus Noise Ratio, SINR, threshold values associated with cell edge UE (112b,112d) served by a particular small cell radio and one or more SINR threshold values associated with cell interior UE (112a,112c) served by the particular small cell radio (114a-114b); and generating one or more messages for each of the one or more small cell radios (114a-114b) identifying the one or more sets of optimized power control parameters. determining, at one or more small cell radios (114a-114b): user equipment, UE, (112a-112d) path loss information between one or more UE (112a-112d) served by one or more small cell radios (114a-114b) and the one or more small radio cells (114a-114b); and macro path loss information from a macro cell radio to each of the one or more small cell radios (114a-114b); the method further comprising: determining, at a central management entity, one or more sets of optimized power control parameters for uplink UE transmissions for the one or more UE (112a-112d) served by the one or more small cell radios (114a-114b), wherein the one or more sets of optimized power control parameters satisfy a first interference constraint associated with limiting interference between the one or more small cell radios and satisfy a second interference constraint associated with limiting interference toward the macro cell radio, wherein determining the one or more sets of optimized power control parameters further comprises: calculating, at the central management entity, one or more sets of candidate power control parameters that meet the first interference constraint for one or more Signal to Interference plus Noise Ratio, SINR, threshold values associated with cell edge UE (112b,112d) served by a particular small cell radio and one or more SINR threshold values associated with cell interior UE (112a,112c) served by the particular small cell radio (114a-114b); and generating one or more messages for each of the one or more small cell radios (114a-114b) identifying the one or more sets of optimized power control parameters. user equipment, UE, (112a-112d) path loss information between one or more UE (112a-112d) served by one or more small cell radios (114a-114b) and the one or more small radio cells (114a-114b); and macro path loss information from a macro cell radio to each of the one or more small cell radios (114a-114b); the method further comprising: determining, at a central management entity, one or more sets of optimized power control parameters for uplink UE transmissions for the one or more UE (112a-112d) served by the one or more small cell radios (114a-114b), wherein the one or more sets of optimized power control parameters satisfy a first interference constraint associated with limiting interference between the one or more small cell radios and satisfy a second interference constraint associated with limiting interference toward the macro cell radio, wherein determining the one or more sets of optimized power control parameters further comprises: calculating, at the central management entity, one or more sets of candidate power control parameters that meet the first interference constraint for one or more Signal to Interference plus Noise Ratio, SINR, threshold values associated with cell edge UE (112b,112d) served by a particular small cell radio and one or more SINR threshold values associated with cell interior UE (112a,112c) served by the particular small cell radio (114a-114b); and generating one or more messages for each of the one or more small cell radios (114a-114b) identifying the one or more sets of optimized power control parameters. calculating, at the central management entity, one or more sets of candidate power control parameters that meet the first interference constraint for one or more Signal to Interference plus Noise Ratio, SINR, threshold values associated with cell edge UE (112b,112d) served by a particular small cell radio and one or more SINR threshold values associated with cell interior UE (112a,112c) served by the particular small cell radio (114a-114b); and generating one or more messages for each of the one or more small cell radios (114a-114b) identifying the one or more sets of optimized power control parameters.