A device for needle biopsy comprising: an adjustable delivery handle system comprising: a delivery handle, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable needle subassemblies; and a sheath coupled to a distal end of the handle and having a lumen in fluid communication with the inner lumen of the delivery handle; and a needle subassembly removably disposed within the inner lumen of the delivery handle and lumen of the sheath, the needle subassembly comprising an exchangeable biopsy needle having an elongate tubular body having a longitudinal axis and comprising a proximal portion having a proximal end, a distal portion having a distal end, an outer surface, and an inner surface defining a lumen extending along the longitudinal axis between the proximal and distal portions, wherein at least one of the distal portion and distal end is configured to capture a sample material within the lumen of the needle wherein the exchangeable biopsy needle further comprises a cutting slot defined on one side of the distal portion of the needle body and extending through the outer and inner surfaces and into the lumen of the needle body, the cutting slot comprising: a proximal cutting end and an opposing distal cutting end; and opposing sidewalls (114a, 114b) defined between the proximal and distal cutting ends and extending along a length of the needle body and parallel to the longitudinal axis, wherein at least one of the proximal and distal cutting ends defines a concave shape (212, 310, 312) having a cutting edge configured to excise a sample material upon contact therewith so as to capture the sample material within the lumen of the needle body, characterized in that the distal end of the needle body is formed from a set of distinct angular bevel grinds (118, 120, 122) oblique to the longitudinal axis of the needle body and defining a pointed tip configured for penetrating material to be sampled. an adjustable delivery handle system comprising: a delivery handle, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable needle subassemblies; and a sheath coupled to a distal end of the handle and having a lumen in fluid communication with the inner lumen of the delivery handle; and a delivery handle, at least a portion of which comprises an inner lumen configured to receive one of a plurality of exchangeable needle subassemblies; and a sheath coupled to a distal end of the handle and having a lumen in fluid communication with the inner lumen of the delivery handle; and a needle subassembly removably disposed within the inner lumen of the delivery handle and lumen of the sheath, the needle subassembly comprising an exchangeable biopsy needle having an elongate tubular body having a longitudinal axis and comprising a proximal portion having a proximal end, a distal portion having a distal end, an outer surface, and an inner surface defining a lumen extending along the longitudinal axis between the proximal and distal portions, wherein at least one of the distal portion and distal end is configured to capture a sample material within the lumen of the needle wherein the exchangeable biopsy needle further comprises a cutting slot defined on one side of the distal portion of the needle body and extending through the outer and inner surfaces and into the lumen of the needle body, the cutting slot comprising: a proximal cutting end and an opposing distal cutting end; and opposing sidewalls (114a, 114b) defined between the proximal and distal cutting ends and extending along a length of the needle body and parallel to the longitudinal axis, a proximal cutting end and an opposing distal cutting end; and opposing sidewalls (114a, 114b) defined between the proximal and distal cutting ends and extending along a length of the needle body and parallel to the longitudinal axis, wherein at least one of the proximal and distal cutting ends defines a concave shape (212, 310, 312) having a cutting edge configured to excise a sample material upon contact therewith so as to capture the sample material within the lumen of the needle body, characterized in that the distal end of the needle body is formed from a set of distinct angular bevel grinds (118, 120, 122) oblique to the longitudinal axis of the needle body and defining a pointed tip configured for penetrating material to be sampled.