A design device for selecting one of a plurality of fastening points for fastening a substrate from a plurality of fastening point candidate positions and setting a combination of the fastening points, the design device comprising: an input unit that accepts a specifying of an evaluation method of a physical quantity acting on a substrate; a physical quantity calculation unit that obtains the physical quantity acting on the substrate according to a combination of fastening points, wherein the physical quantity is a natural frequency of the substrate; a regression model generation unit that generates a regression model which approximates a relation between the physical quantity acting on the substrate and the combination of fastening points based on data of the physical quantity corresponding to the combination of the fastening points and has a binary variable representing one of a plurality of fastening point candidates; an Ising model conversion unit that converts the regression model into an Ising model based on the evaluation method specified in the input unit; a fastening point selection unit that determine the combination of fastening points by selecting the one of the plurality of fastening points from the plurality of fastening point candidate positions using an Ising machine so as to minimize an evaluation value of the Ising model; and an output unit that outputs data of the combination of the fastening points, wherein: following processes are repeatedly performed until a predetermined termination condition is satisfied: the physical quantity calculation unit calculates the physical quantity acting on the substrate according to the fastening points selected by the fastening point selection unit; the regression model generation unit generates another regression model based on a data set of the physical quantity calculated by the physical quantity calculation unit and a corresponding combination of the fastening points; the Ising model conversion unit converts the regression model into the Ising model; and the fastening point selection unit selects the combination of fastening points based on the Ising model. an input unit that accepts a specifying of an evaluation method of a physical quantity acting on a substrate; a physical quantity calculation unit that obtains the physical quantity acting on the substrate according to a combination of fastening points, wherein the physical quantity is a natural frequency of the substrate; a regression model generation unit that generates a regression model which approximates a relation between the physical quantity acting on the substrate and the combination of fastening points based on data of the physical quantity corresponding to the combination of the fastening points and has a binary variable representing one of a plurality of fastening point candidates; an Ising model conversion unit that converts the regression model into an Ising model based on the evaluation method specified in the input unit; a fastening point selection unit that determine the combination of fastening points by selecting the one of the plurality of fastening points from the plurality of fastening point candidate positions using an Ising machine so as to minimize an evaluation value of the Ising model; and an output unit that outputs data of the combination of the fastening points, wherein: following processes are repeatedly performed until a predetermined termination condition is satisfied: the physical quantity calculation unit calculates the physical quantity acting on the substrate according to the fastening points selected by the fastening point selection unit; the regression model generation unit generates another regression model based on a data set of the physical quantity calculated by the physical quantity calculation unit and a corresponding combination of the fastening points; the Ising model conversion unit converts the regression model into the Ising model; and the fastening point selection unit selects the combination of fastening points based on the Ising model. the physical quantity calculation unit calculates the physical quantity acting on the substrate according to the fastening points selected by the fastening point selection unit; the regression model generation unit generates another regression model based on a data set of the physical quantity calculated by the physical quantity calculation unit and a corresponding combination of the fastening points; the Ising model conversion unit converts the regression model into the Ising model; and the fastening point selection unit selects the combination of fastening points based on the Ising model.