A device for separating compounds in a solution from each other or undesired components of the solution, said device comprising: a body having an interior surface, an exterior surface, a first opening at a first body end and a second opening at a second body end, said first opening and said second opening defining a boundary between said interior surface and said exterior surface, said interior surface having at least one wall creating a passage in said body, wherein proximal to said first body end, said passage has a frit section for holding a frit, and a media chamber holding a separation media effecting separations of compounds in solutions flowing therethrough and proximal to said second body end, a manifold section for receiving a fluid from, or discharging a fluid to, said frit section, and a frit element (17a, 17b) comprising a first frit and a second frit for retaining the separation media, the first frit received in said frit section, and the second frit held in an opening of a frit sealing ring received at said first body end, said exterior surface has a first attachment means positioned radially about said media chamber and said frit section, and at least one of the exterior surface and interior surface has a second attachment means at the second body end, end, said body, via its first and second attachment means (51, 141), receiving a first union means (55, 57) and a second union means for placing said passage in fluid communication with a solution containing at least one compound to effect separation of the compound from at least one of the group selected from other compounds in the solution or undesired components of the solution, wherein said first union means (55, 57) is positioned towards said first body end for placing said media chamber in fluid communication with at least one of a source of fluid, fluid discharge conduit, column and detector, and said second union means is positioned towards said second body end for placing said manifold section in fluid communication with at least one of the group consisting of a source of fluid, discharge conduit, column and detector, wherein said second frit has a frit thickness and said second frit sealing ring has a sealing ring thickness and said frit thickness exceeds said sealing ring thickness to project outside the frit seal ring opening to form a second frit projection. a body having an interior surface, an exterior surface, a first opening at a first body end and a second opening at a second body end, said first opening and said second opening defining a boundary between said interior surface and said exterior surface, said interior surface having at least one wall creating a passage in said body, wherein proximal to said first body end, said passage has a frit section for holding a frit, and a media chamber holding a separation media effecting separations of compounds in solutions flowing therethrough and proximal to said second body end, a manifold section for receiving a fluid from, or discharging a fluid to, said frit section, and a frit element (17a, 17b) comprising a first frit and a second frit for retaining the separation media, the first frit received in said frit section, and the second frit held in an opening of a frit sealing ring received at said first body end, said exterior surface has a first attachment means positioned radially about said media chamber and said frit section, and at least one of the exterior surface and interior surface has a second attachment means at the second body end, end, said body, via its first and second attachment means (51, 141), receiving a first union means (55, 57) and a second union means for placing said passage in fluid communication with a solution containing at least one compound to effect separation of the compound from at least one of the group selected from other compounds in the solution or undesired components of the solution, wherein said first union means (55, 57) is positioned towards said first body end for placing said media chamber in fluid communication with at least one of a source of fluid, fluid discharge conduit, column and detector, and said second union means is positioned towards said second body end for placing said manifold section in fluid communication with at least one of the group consisting of a source of fluid, discharge conduit, column and detector, wherein said second frit has a frit thickness and said second frit sealing ring has a sealing ring thickness and said frit thickness exceeds said sealing ring thickness to project outside the frit seal ring opening to form a second frit projection.