A compound of general Formula I and stereoisomers, pharmaceutically acceptable salts and solvates thereof, wherein: R 1 is H, halogen, CN, OH, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy alkyl, cyano alkyl, (1-3C alkoxy) alkyl (optionally substituted with hydroxy), di(1-3C alkoxy) alkyl, alkoxy, fluoro alkoxy, difluoro alkoxy, trifluoro alkoxy, hydroxy alkoxy, cyano alkoxy, (1-3C alkoxy) alkoxy, di(1-3C alkoxy) alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (optionally substituted with methyl), (1-6C alkyl)sulfanyl, -C(=O)NR a R b, -CH 2 C(=O)NR c R d, or cycloalkyl optionally substituted with -CH 2 OH or -CH 2 O(1-4C alkyl); R a, R b, R c and R d are independently selected from H and alkyl; R 2 is H, halogen, CN, OH, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy alkyl, (1-3C alkoxy) alkyl, alkoxy (optionally substituted with (1-6C alkyl)C(=O)O-, amino(1-6C alkyl)C(=O)O-, or phenyl(C=O)O-), fluoro alkoxy, difluoro alkoxy, trifluoro alkoxy, hydroxy alkoxy, (1-3C alkoxy) alkoxy, (3-6C cycloalkyl)methoxy, cycloalkoxy (optionally substituted with OH), oxetanylmethoxy (optionally substituted with methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanyl, hydroxy(2-6C alkyl)sulfanyl, (1-3C alkylsulfanyl) alkoxy,-COOH, hetAr 1, - C(=O)NR e R f, -NR e C(=O)R f, oxetanyl, or cyclopropyl optionally substituted with -CH 2 OH or - CH 2 O(1-6C alkyl); or R 1 and R 2 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having 1 - 2 ring heteroatoms independently selected from O and N, wherein said ring is optionally substituted with alkyl; hetAr 1 is a 5-6 membered heteroaryl ring having one or two ring nitrogen atoms and optionally substituted with one or more groups selected from alkyl; R e and R f are independently H, alkyl or cyclopropyl optionally substituted with alkyl; R 3 is H, halogen or alkyl; R 4 is R 5 is CF 3, CH 2 F, CHF 2, methyl or ethyl; R 5a is H or methyl; or R 5 and R 5a together with the atom to which they are attached form a cyclopropyl ring; R 6 is H, NH 2, OH, (1-6C alkyl)NH-, fluoro(1-6C alkyl)NH-, hydroxy(1-6C alkyl)NH-, (3-6C cycloalkyl)CH 2 NH-, (1-6C alkyl)C(=O)NH-, (1-6C alkyl)OC(=O)NH- (optionally substituted with 5-methyl-2-oxo-1,3-dioxol-4-yl) or amino alkyl-; R 7 is H, alkyl, fluoro alkyl or hydroxy alkyl; or R 6 and R 7 together with the atom to which they are attached form a 5-6 membered spirocyclic heterocycle having a ring nitrogen atom; R 8 is H, halogen, OH, or alkoxy, or R 6 and R 8 together with the carbon atoms to which they are attached form a cyclopropyl ring optionally substituted with NH 2; R 9 is H, or R 6 and R 9 together form a linking group having the formula -CH 2 NH- which links the carbon atoms to which they are attached; and R 10 is H or halogen. R 1 is H, halogen, CN, OH, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy alkyl, cyano alkyl, (1-3C alkoxy) alkyl (optionally substituted with hydroxy), di(1-3C alkoxy) alkyl, alkoxy, fluoro alkoxy, difluoro alkoxy, trifluoro alkoxy, hydroxy alkoxy, cyano alkoxy, (1-3C alkoxy) alkoxy, di(1-3C alkoxy) alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (optionally substituted with methyl), (1-6C alkyl)sulfanyl, -C(=O)NR a R b, -CH 2 C(=O)NR c R d, or cycloalkyl optionally substituted with -CH 2 OH or -CH 2 O(1-4C alkyl); R a, R b, R c and R d are independently selected from H and alkyl; R 2 is H, halogen, CN, OH, alkyl, fluoro alkyl, difluoro alkyl, trifluoro alkyl, hydroxy alkyl, (1-3C alkoxy) alkyl, alkoxy (optionally substituted with (1-6C alkyl)C(=O)O-, amino(1-6C alkyl)C(=O)O-, or phenyl(C=O)O-), fluoro alkoxy, difluoro alkoxy, trifluoro alkoxy, hydroxy alkoxy, (1-3C alkoxy) alkoxy, (3-6C cycloalkyl)methoxy, cycloalkoxy (optionally substituted with OH), oxetanylmethoxy (optionally substituted with methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanyl, hydroxy(2-6C alkyl)sulfanyl, (1-3C alkylsulfanyl) alkoxy,-COOH, hetAr 1, - C(=O)NR e R f, -NR e C(=O)R f, oxetanyl, or cyclopropyl optionally substituted with -CH 2 OH or - CH 2 O(1-6C alkyl); or R 1 and R 2 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having 1 - 2 ring heteroatoms independently selected from O and N, wherein said ring is optionally substituted with alkyl; hetAr 1 is a 5-6 membered heteroaryl ring having one or two ring nitrogen atoms and optionally substituted with one or more groups selected from alkyl; R e and R f are independently H, alkyl or cyclopropyl optionally substituted with alkyl; R 3 is H, halogen or alkyl; R 4 is R 5 is CF 3, CH 2 F, CHF 2, methyl or ethyl; R 5a is H or methyl; or R 5 and R 5a together with the atom to which they are attached form a cyclopropyl ring; R 6 is H, NH 2, OH, (1-6C alkyl)NH-, fluoro(1-6C alkyl)NH-, hydroxy(1-6C alkyl)NH-, (3-6C cycloalkyl)CH 2 NH-, (1-6C alkyl)C(=O)NH-, (1-6C alkyl)OC(=O)NH- (optionally substituted with 5-methyl-2-oxo-1,3-dioxol-4-yl) or amino alkyl-; R 7 is H, alkyl, fluoro alkyl or hydroxy alkyl; or R 6 and R 7 together with the atom to which they are attached form a 5-6 membered spirocyclic heterocycle having a ring nitrogen atom; R 8 is H, halogen, OH, or alkoxy, or R 6 and R 8 together with the carbon atoms to which they are attached form a cyclopropyl ring optionally substituted with NH 2; R 9 is H, or R 6 and R 9 together form a linking group having the formula -CH 2 NH- which links the carbon atoms to which they are attached; and R 10 is H or halogen.