A system for recommending a second dosage of a pharmaceutical composition for administration to a subject who has previously received a first dosage of said pharmaceutical composition, comprising means for carrying out the steps of: (a) obtaining, with the aid of a point of care system comprising a POC module and a drug-monitoring module, said POC module for monitoring, with the aid of a computer processor, a concentration of an active ingredient of a pharmaceutical composition or a metabolite thereof, or a biological marker indicative of the concentration of said pharmaceutical composition, and the hemoglobin concentration in said subject, and said drug monitoring module for providing one or more set point concentrations of an active ingredient of a pharmaceutical composition or a metabolite thereof and a predicted hemoglobin concentration in the subject who has received a first dose of a pharmaceutical composition at a first time (b) measuring, with the aid of the point of care system and the biological sample, the concentration of an active ingredient of said pharmaceutical composition or a metabolite thereof, or a biological marker indicative of the concentration of said pharmaceutical composition, and the hemoglobin concentration present in said sample obtained from the subject; and (c) calculating, with the aid of a computer processor, a recommended second dosage or time interval between dosages based on the pharmaceutical composition concentration measured in step (b) wherein if the measured pharmaceutical composition concentration is below the set point concentration, the system increases dose or decrease time between drug administrations or, if the measured pharmaceutical composition concentration is not below the set point, the system determines whether the measured concentration is above the set point, the system decreases the dose or increases the time between drug administration, or if the measured pharmaceutical composition concentration is not above the set point, the system does not change the dose and (d) increasing sampling frequency of the sample measurement in step (b) if the measured hemoglobin concentration is different from the predicted hemoglobin concentration, wherein the biological sample is blood and, wherein the set point concentration and the predicted hemoglobin concentration is calculated or updated with the aid of subject-specific pharmacokinetic data and subject-specific pharmacodynamic data. (a) obtaining, with the aid of a point of care system comprising a POC module and a drug-monitoring module, said POC module for monitoring, with the aid of a computer processor, a concentration of an active ingredient of a pharmaceutical composition or a metabolite thereof, or a biological marker indicative of the concentration of said pharmaceutical composition, and the hemoglobin concentration in said subject, and said drug monitoring module for providing one or more set point concentrations of an active ingredient of a pharmaceutical composition or a metabolite thereof and a predicted hemoglobin concentration in the subject who has received a first dose of a pharmaceutical composition at a first time (b) measuring, with the aid of the point of care system and the biological sample, the concentration of an active ingredient of said pharmaceutical composition or a metabolite thereof, or a biological marker indicative of the concentration of said pharmaceutical composition, and the hemoglobin concentration present in said sample obtained from the subject; and (c) calculating, with the aid of a computer processor, a recommended second dosage or time interval between dosages based on the pharmaceutical composition concentration measured in step (b) wherein if the measured pharmaceutical composition concentration is below the set point concentration, the system increases dose or decrease time between drug administrations or, if the measured pharmaceutical composition concentration is not below the set point, the system determines whether the measured concentration is above the set point, the system decreases the dose or increases the time between drug administration, or if the measured pharmaceutical composition concentration is not above the set point, the system does not change the dose and (d) increasing sampling frequency of the sample measurement in step (b) if the measured hemoglobin concentration is different from the predicted hemoglobin concentration, wherein the biological sample is blood and, wherein the set point concentration and the predicted hemoglobin concentration is calculated or updated with the aid of subject-specific pharmacokinetic data and subject-specific pharmacodynamic data. wherein the biological sample is blood and, wherein the set point concentration and the predicted hemoglobin concentration is calculated or updated with the aid of subject-specific pharmacokinetic data and subject-specific pharmacodynamic data.