A mechanical thrombectomy apparatus, comprising: a thrombus removal head, connected to a sheath connector through a sheath; a thrombus fragmentation system, comprising a rotation actuator, a transmission tube, and a thrombus fragmentation cutter, wherein a proximal end of the transmission tube is connected to the rotation actuator, a distal end of the transmission tube is connected to the thrombus fragmentation cutter, and the transmission tube extends into the thrombus removal head along lumens of the sheath connector and the sheath; when driven by the rotation actuator, the transmission tube is able to rotate and drive the thrombus fragmentation cutter to rotate, so as to fragment a thrombus aspirated into the thrombus removal head; a thrombus aspiration system, comprising an aspiration device and a thrombus aspiration tube, wherein a proximal end of the thrombus aspiration tube is connected to the aspiration device, and a distal end of the thrombus aspiration tube is connected to the sheath connector; a cavity formed between the transmission tube and the sheath is communicated with the thrombus aspiration tube to form a thrombus aspiration lumen; and a drug perfusion system, comprising an injector and an infusion tube, a proximal end of the infusion tube is connected to the injector, a distal end of the infusion tube is communicated with the transmission tube to allow a drug to pass through the transmission tube and the thrombus removal head to reach a site of a thrombus; wherein the aspiration device is a peristaltic pump, and the thrombus aspiration tube is a flexible tube; and wherein the thrombus removal head has a distal end that has a tapered structure and has at least one inclined hole and a top hole, and the inclined hole and the top hole are configured so that the drug is allowed be perfused therethrough; and wherein the top hole is formed at a tip of the tapered structure. a thrombus removal head, connected to a sheath connector through a sheath; a thrombus fragmentation system, comprising a rotation actuator, a transmission tube, and a thrombus fragmentation cutter, wherein a proximal end of the transmission tube is connected to the rotation actuator, a distal end of the transmission tube is connected to the thrombus fragmentation cutter, and the transmission tube extends into the thrombus removal head along lumens of the sheath connector and the sheath; when driven by the rotation actuator, the transmission tube is able to rotate and drive the thrombus fragmentation cutter to rotate, so as to fragment a thrombus aspirated into the thrombus removal head; a thrombus aspiration system, comprising an aspiration device and a thrombus aspiration tube, wherein a proximal end of the thrombus aspiration tube is connected to the aspiration device, and a distal end of the thrombus aspiration tube is connected to the sheath connector; a cavity formed between the transmission tube and the sheath is communicated with the thrombus aspiration tube to form a thrombus aspiration lumen; and a drug perfusion system, comprising an injector and an infusion tube, a proximal end of the infusion tube is connected to the injector, a distal end of the infusion tube is communicated with the transmission tube to allow a drug to pass through the transmission tube and the thrombus removal head to reach a site of a thrombus; wherein the aspiration device is a peristaltic pump, and the thrombus aspiration tube is a flexible tube; and wherein the thrombus removal head has a distal end that has a tapered structure and has at least one inclined hole and a top hole, and the inclined hole and the top hole are configured so that the drug is allowed be perfused therethrough; and wherein the top hole is formed at a tip of the tapered structure.