A computer-implemented method for computing an assessment of a medical issue of a patient, comprising: receiving a user input, the user input comprising medical image data of the patient and at least one variable value, the variable value being indicative of a variable parameter of the medical image data related to a medical issue of the patient; associating each of the at least one variable values with a corresponding variable parameter to generate at least one variable-value pair; determining whether at least one further variable-value pair related to a medical issue of the patient is required to determine a computed output value indicative of an assessment of a medical issue of the patient as a function of select ones of the at least one variable-value pair, wherein the determination for at least one further variable-value pair is a function of at least one of predetermined settings and predetermined rules; when at least one further variable-value pair is required, - determining the at least one further variable-value pair necessary to determine the computed output value, - requesting for the at least one further variable-value pair, and - receiving the at least one further variable-value pair prior to determining the computed output value; and determining the computed output value as a function of the at least one further variable-value pair and select ones of the at least one generated variable-value pair. receiving a user input, the user input comprising medical image data of the patient and at least one variable value, the variable value being indicative of a variable parameter of the medical image data related to a medical issue of the patient; associating each of the at least one variable values with a corresponding variable parameter to generate at least one variable-value pair; determining whether at least one further variable-value pair related to a medical issue of the patient is required to determine a computed output value indicative of an assessment of a medical issue of the patient as a function of select ones of the at least one variable-value pair, wherein the determination for at least one further variable-value pair is a function of at least one of predetermined settings and predetermined rules; when at least one further variable-value pair is required, - determining the at least one further variable-value pair necessary to determine the computed output value, - requesting for the at least one further variable-value pair, and - receiving the at least one further variable-value pair prior to determining the computed output value; and determining the computed output value as a function of the at least one further variable-value pair and select ones of the at least one generated variable-value pair. - determining the at least one further variable-value pair necessary to determine the computed output value, - requesting for the at least one further variable-value pair, and - receiving the at least one further variable-value pair prior to determining the computed output value; and determining the computed output value as a function of the at least one further variable-value pair and select ones of the at least one generated variable-value pair.