A surgical instrument (10; 410) for treating a tissue of a patient, comprising: (a) a shaft assembly; (b) an end effector (40; 412) extending from the shaft assembly along a jaw centerline, the end effector comprising: (i) a first jaw having an anvil (60; 424) configured to form a plurality of staples (77, 444) pressed against the anvil, and (ii) a second jaw (50; 420), wherein the first and second jaws are configured to transition between an open configuration and a closed configuration; and (c) a staple cartridge (70; 418) received within the second jaw, the staple cartridge comprising: (i) a deck (73; 438) facing the anvil, wherein the deck defines a plurality of staple openings (74; 442), the plurality of staple openings comprising a first row of staple openings and a second row of staple openings, the first and second rows of staple openings defining a first row centerline therebetween, (ii) a plurality of staples positioned respectively within the plurality of staple openings, (iii) a first driver assembly (75; 492) positioned on the first row centerline, wherein the first driver assembly is asymmetric about the first row centerline and is configured to drive a first portion of the plurality of staples, and (iv) a second driver assembly (75; 492) positioned on the first row centerline, wherein the second driver assembly is asymmetric about the first row centerline and is configured to drive a second portion of the plurality of staples; wherein the first and second driver assemblies alternate such that the first and second driver assemblies overlap in a direction transverse to the first row centerline for forming offset and overlapping staple rows in tissue. (a) a shaft assembly; (b) an end effector (40; 412) extending from the shaft assembly along a jaw centerline, the end effector comprising: (i) a first jaw having an anvil (60; 424) configured to form a plurality of staples (77, 444) pressed against the anvil, and (ii) a second jaw (50; 420), wherein the first and second jaws are configured to transition between an open configuration and a closed configuration; and (i) a first jaw having an anvil (60; 424) configured to form a plurality of staples (77, 444) pressed against the anvil, and (ii) a second jaw (50; 420), wherein the first and second jaws are configured to transition between an open configuration and a closed configuration; and (c) a staple cartridge (70; 418) received within the second jaw, the staple cartridge comprising: (i) a deck (73; 438) facing the anvil, wherein the deck defines a plurality of staple openings (74; 442), the plurality of staple openings comprising a first row of staple openings and a second row of staple openings, the first and second rows of staple openings defining a first row centerline therebetween, (ii) a plurality of staples positioned respectively within the plurality of staple openings, (iii) a first driver assembly (75; 492) positioned on the first row centerline, wherein the first driver assembly is asymmetric about the first row centerline and is configured to drive a first portion of the plurality of staples, and (iv) a second driver assembly (75; 492) positioned on the first row centerline, wherein the second driver assembly is asymmetric about the first row centerline and is configured to drive a second portion of the plurality of staples; (i) a deck (73; 438) facing the anvil, wherein the deck defines a plurality of staple openings (74; 442), the plurality of staple openings comprising a first row of staple openings and a second row of staple openings, the first and second rows of staple openings defining a first row centerline therebetween, (ii) a plurality of staples positioned respectively within the plurality of staple openings, (iii) a first driver assembly (75; 492) positioned on the first row centerline, wherein the first driver assembly is asymmetric about the first row centerline and is configured to drive a first portion of the plurality of staples, and (iv) a second driver assembly (75; 492) positioned on the first row centerline, wherein the second driver assembly is asymmetric about the first row centerline and is configured to drive a second portion of the plurality of staples;