mhurhangee/ep-ind-claims huggingface dataset:
A neuromodulation system, comprising: a shaft including a proximal portion and a distal portion, wherein the shaft is configured to intravascularly locate the distal portion at a treatment site within a blood vessel of a human patient; a neuromodulation assembly at the distal portion of the shaft; and a nerve monitoring assembly at the distal portion of the shaft and transformable between a delivery state and a deployed state, wherein the nerve monitoring assembly comprises a stimulation electrode array and a recording electrode array, and wherein, in the deployed state, the stimulation electrode array and the recording electrode array are spaced laterally apart from one another and at least a portion of the neuromodulation assembly is between the stimulation and recording electrode arrays, wherein at least one of the stimulation and recording electrode arrays includes a multi-electrode loop having at least four electrodes spaced circumferentially around the loop. a shaft including a proximal portion and a distal portion, wherein the shaft is configured to intravascularly locate the distal portion at a treatment site within a blood vessel of a human patient; a neuromodulation assembly at the distal portion of the shaft; and a nerve monitoring assembly at the distal portion of the shaft and transformable between a delivery state and a deployed state, wherein the nerve monitoring assembly comprises a stimulation electrode array and a recording electrode array, and wherein, in the deployed state, the stimulation electrode array and the recording electrode array are spaced laterally apart from one another and at least a portion of the neuromodulation assembly is between the stimulation and recording electrode arrays, wherein at least one of the stimulation and recording electrode arrays includes a multi-electrode loop having at least four electrodes spaced circumferentially around the loop.
An expandable, removable and reusable modular high-rise building, made up of prefabricated elements comprising: - a modular structure, comprising pillars, beams, and quick coupling nodes for joining between the pillars and the beams, and - self-supporting modules with dimensions greater than the span between beams of the modular structure, wherein each module comprises: - a base slab comprising lower longitudinal beams joined by lower transversal beams and the corresponding compression layer, - upper longitudinal beams joined by upper transversal beams, - pillars that are joined to the lower longitudinal beams and the upper longitudinal beams, and - smaller and larger perimeter envelopes (67a, 67b) and upper envelopes; - in the perimeter envelopes (67a, 67b) of which there are holes (69a, 69b) made for passage, illumination and ventilation, characterized in that each module further comprises, at least, an intermediate narrowing in the larger envelopes for the passage of the vertical elements of the structure and utility ducts for installations. - a modular structure, comprising pillars, beams, and quick coupling nodes for joining between the pillars and the beams, and - self-supporting modules with dimensions greater than the span between beams of the modular structure, - a base slab comprising lower longitudinal beams joined by lower transversal beams and the corresponding compression layer, - upper longitudinal beams joined by upper transversal beams, - pillars that are joined to the lower longitudinal beams and the upper longitudinal beams, and - smaller and larger perimeter envelopes (67a, 67b) and upper envelopes; - in the perimeter envelopes (67a, 67b) of which there are holes (69a, 69b) made for passage, illumination and ventilation,
Packaging for a generally block shaped product, the packaging comprising a wrapper of flexible material encasing the product, the wrapper having a foldable flap portion adjacent or in-board of an end of the packaging, the free edges of the flap overlapping a further portion of the wrapper and being bonded thereto by means of a peelable and re-sealable adhesive, the flap extending at least partially across a face of the packaging to form a sealed and re-sealable closure for the packaging and wherein the free edges of the flap can be peeled away from the further portion of the wrapper and the flap folded back to expose an opening at one end of the packaging through which the product can be removed; characterised in that the packaging further comprises at least one peelable panel portion (684, 686) formed in a face of the packaging and configured such that, in use, the at least one peelable panel portion (684, 686) can be peeled away from the remainder of its respective face to increase the depth of the opening in the packaging produced when the flap is opened.
Method for assisting in remote diagnosis, by a piece of administrative equipment, of an access gateway, said gateway allowing access to a wide area communication network via an access network, said method comprising the steps of: - detection of a fault affecting access by the gateway to the wide area communication network via said access network; - obtainment, by a device (31, 50), of an identifier for the access gateway and of a datum for assisting in a diagnosis of the fault by means of a radio communication channel, said device being separate from said access gateway and from the administrative equipment; - sending, by said device, of said identifier and of said datum, which have been obtained via an access means in working order, to the administrative equipment, the access to the wide area communication network by the device being effected without the intervention of the gateway. - detection of a fault affecting access by the gateway to the wide area communication network via said access network; - obtainment, by a device (31, 50), of an identifier for the access gateway and of a datum for assisting in a diagnosis of the fault by means of a radio communication channel, said device being separate from said access gateway and from the administrative equipment; - sending, by said device, of said identifier and of said datum, which have been obtained via an access means in working order, to the administrative equipment, the access to the wide area communication network by the device being effected without the intervention of the gateway.
CHIR99021, or a pharmaceutically acceptable salt thereof, for use in the treatment of a disorder of the inner ear in a subject in need thereof, wherein the CHIR99021, or a pharmaceutically acceptable salt thereof, is administered in combination with valproic acid, or a pharmaceutically acceptable salt thereof, and wherein the treatment comprises generating epithelial tissue in the subject by administering the CHIR99021, or a pharmaceutically acceptable salt thereof, and the VPA, or a pharmaceutically acceptable salt thereof, to the subject in an amount sufficient to increase LGR5 positive epithelial stem cells present within the inner ear through administration of the CHIR99021, or a pharmaceutically acceptable salt thereof, and the VPA, or a pharmaceutically acceptable salt thereof, to the subject. wherein the CHIR99021, or a pharmaceutically acceptable salt thereof, is administered in combination with valproic acid, or a pharmaceutically acceptable salt thereof, and wherein the treatment comprises generating epithelial tissue in the subject by administering the CHIR99021, or a pharmaceutically acceptable salt thereof, and the VPA, or a pharmaceutically acceptable salt thereof, to the subject in an amount sufficient to increase LGR5 positive epithelial stem cells present within the inner ear through administration of the CHIR99021, or a pharmaceutically acceptable salt thereof, and the VPA, or a pharmaceutically acceptable salt thereof, to the subject.
An apparatus for cooking food with superheated steam comprising an outer casing, which comprises inside it a cooking chamber, adapted to contain one or more foods; a steam generating device associated with said casing, adapted to vaporize a liquid, said steam generating device comprising at least one heating element and at least one thermally conductive element, said at least one heating element being adapted to heat said inserted liquid, in use, inside said steam generating device, said heating element also being adapted to heat said thermally conductive element so as to store a predetermined amount of energy to be used to generate steam in said thermally conductive element, said at least one heating element comprising an electric resistance, each said electric resistance having a substantially flat spiral shape; a superheating device of said steam associated to said steam generating device, said superheating device being configured to heat said steam up to an operating temperature higher than the boiling temperature of said liquid and to allow said superheated steam to come out towards said cooking chamber; characterized in that said steam generating device comprises a body comprising a plurality of electrical resistances, arranged alternating with respective said thermally conductive elements. a steam generating device associated with said casing, adapted to vaporize a liquid, said steam generating device comprising at least one heating element and at least one thermally conductive element, said at least one heating element being adapted to heat said inserted liquid, in use, inside said steam generating device, said heating element also being adapted to heat said thermally conductive element so as to store a predetermined amount of energy to be used to generate steam in said thermally conductive element, said at least one heating element comprising an electric resistance, each said electric resistance having a substantially flat spiral shape; a superheating device of said steam associated to said steam generating device, said superheating device being configured to heat said steam up to an operating temperature higher than the boiling temperature of said liquid and to allow said superheated steam to come out towards said cooking chamber; characterized in that said steam generating device comprises a body comprising a plurality of electrical resistances, arranged alternating with respective said thermally conductive elements.
A roller press for grinding of particulate material such as cement raw materials, cement clinker and similar materials, which roller press comprises two oppositely rotating rollers (2, 3) forming between them a roller gap and a co-rotating annular disc, which in concentric manner is attached to an end surface (6, 7) of one of the rollers by means of a number of resilient attachment elements and being movable in the direction of the roller axis, where the outer diameter of said annular disc is greater than the diameter of said one of the rollers, hence the annular disc in the area of the roller gap extends toward the other roller, thus covering at least part of the roller gap, characterized in that the inner diameter of the annular disc is smaller than the diameter of the roller, to which it is attached, thus overlapping the end surface (6, 7) of said roller, and that the resilient attachment elements are evenly distributed over the circumference of the annular disc and provided with spaces or openings there between.
Device for guiding cell migration comprising a support surface provided with cells and a substrate, said substrate having a textured surface (6; 6'; 6") disposed facing the support surface and placed in contact with the cells disposed on the support surface so that the cells are confined between the support surface and the textured surface (6; 6'; 6"), said textured surface (6; 6'; 6") having an anisotropic three-dimensional structure (8; 8'; 8") having a repeating pattern along a repeat axis, said repeating pattern having a succession of adjacent guide spaces (15; 25; 35) along the repeat axis, each of said guide spaces (15; 25; 35) being configured to receive at least a part of one of the cells and being oriented in a direction of anisotropy (A1; A2; A3a, A3b) in order to guide a movement of the cells in the direction of anisotropy (A1; A2; A3a, A3b).
A deaerator including a tank with an outlet fitting and a steam source, a deaerator column with a cover mounted on the tank with fittings for water inlet (4, 5) and vapor blowdown located on it, containing lower and upper deaeration sections each having pressure (8, 13) and distribution (10, 15) trays installed so as to form a jet chamber (9, 14) in the area between them, and random element packing (12, 17), wherein the deaeration sections are separated by a hydraulic seal formed by an edge and a projection connected to the column cover, with water inlet (4, 5) and vapor blowdown fittings located inside the hydraulic seal projection, characterized in that the hydraulic seal projection has openings the lower edges of which are located higher than the upper side of the hydraulic seal edge by the value exceeding the sum of overflow height of the coolant over the hydraulic seal edge and hydraulic resistance of the hydraulic seal channel, while the total cross section of the openings is determined by the equality of steam pressure in the blowdown fitting and in the area inside the hydraulic seal projection.
A multilayer component in solid wood with at least three layers assembled together in a cross, each one consisting of several strips, where the strips are facing one another and are characterised by plane surfaces (2, 3) and longitudinal slots (4, 5), so that there is a winding cross section on the front part, given that all the layers are inextricably bound without glue.
A method for safety monitoring of a joint of a serial kinematics, which carries out tasks under the control of a control unit, wherein for safety monitoring a current state variable of the joint, such as the absolute position or the time derivatives thereof, being determined cyclically from the current axis position of the joint and being compared to a configurable limit value (SA, TA, SL), wherein a function module (3, 4, 5) being used to monitor the state variable and the current axis position of the joint of the serial kinematics being detected in the safety monitoring unit independently of the control unit, and based thereon a current state variable of the joint being calculated in the safety monitoring unit, the current state variable of the joint being compared to the limit value (SA, TA, SL) thereof and the result of the comparison (SLO, SLP, SLS) being output by the safety monitoring unit, characterized in that the function module (3, 4, 5) is activated or deactivated independently of the control unit during a sequence of motions of the serial kinematics.
A device for monitoring athletic performance of a user, the device comprising: a wristband (14; 114; 514) configured to be worn by the user; and an electronic module (12; 112; 412; 512) removably attached to the wristband, the electronic module having a controller (18; 118; 418), the electronic module further having a plurality of user inputs operably associated with the controller, the plurality of user inputs including a first user input (50; 150) operable along an x- axis direction, and a second user input (52; 152) operable along a y-axis direction, and a third user input (54; 154) comprising an accelerometer operably connected to the controller and operable along a z-axis direction, wherein the electronic module has a screen (39; 139); characterized in that the third input is arranged to be activated by tapping the screen to mark a lap; and wherein, upon marking a lap, the controller is configured to prevent any further laps from being marked in response to tapping of the screen for a set period of time. a wristband (14; 114; 514) configured to be worn by the user; and an electronic module (12; 112; 412; 512) removably attached to the wristband, the electronic module having a controller (18; 118; 418), the electronic module further having a plurality of user inputs operably associated with the controller, the plurality of user inputs including a first user input (50; 150) operable along an x- axis direction, and a second user input (52; 152) operable along a y-axis direction, and a third user input (54; 154) comprising an accelerometer operably connected to the controller and operable along a z-axis direction, wherein the electronic module has a screen (39; 139); characterized in that the third input is arranged to be activated by tapping the screen to mark a lap; and wherein, upon marking a lap, the controller is configured to prevent any further laps from being marked in response to tapping of the screen for a set period of time.
A method of making a seal ring (111, 112) for a seal assembly (30, 36), the method of making comprising: producing the seal ring (111, 112), the seal ring (111, 112) including a load end, a seal end, a loading surface, and a sealing face, the load end and the seal end in spaced relationship to each other along a longitudinal axis, the loading surface extending along the longitudinal axis between the load end and the seal end, the sealing face being disposed at the seal end and being annular, the sealing face extending radially with respect to the longitudinal axis; applying a layer of coating composition to at least a portion of an exterior surface of the seal ring (111, 112); machining the sealing face of the seal ring (111, 112) to define a sealing band; after the layer of coating composition is applied, placing a mask (300, 400) over at least an area of the layer of coating composition applied to the exterior surface of the seal ring (111, 112), the mask (300, 400) being positioned with respect to the sealing band such that the mask (300, 400) is offset from the sealing band to leave the sealing band exposed; after the mask (300, 400) is placed, polishing the sealing band by subjecting the sealing band to an isotropic finishing process. producing the seal ring (111, 112), the seal ring (111, 112) including a load end, a seal end, a loading surface, and a sealing face, the load end and the seal end in spaced relationship to each other along a longitudinal axis, the loading surface extending along the longitudinal axis between the load end and the seal end, the sealing face being disposed at the seal end and being annular, the sealing face extending radially with respect to the longitudinal axis; applying a layer of coating composition to at least a portion of an exterior surface of the seal ring (111, 112); machining the sealing face of the seal ring (111, 112) to define a sealing band; after the layer of coating composition is applied, placing a mask (300, 400) over at least an area of the layer of coating composition applied to the exterior surface of the seal ring (111, 112), the mask (300, 400) being positioned with respect to the sealing band such that the mask (300, 400) is offset from the sealing band to leave the sealing band exposed; after the mask (300, 400) is placed, polishing the sealing band by subjecting the sealing band to an isotropic finishing process.
A jumper (30, 40) for a timepiece movement, of the type comprising a base intended to be attached to a frame element of said timepiece movement and from which extends an arm which can be elastically deformed, said arm bearing an abutment surface intended to cooperate with at least one notch of a mobile (222, 242) which can be set in motion relative to said frame element in order to temporarily immobilize said mobile (222, 242) in a determined position, characterized in that said base comprises a support element which bears said arm, and two link elements (54, 56) which link the support element to a fixed element of the base, in that the support element, the two link elements (54, 56) and the fixed element form sides of a frame, and in that said frame is arranged to be elastically deformed so as to provoke a displacement of the support element and of the arm that it bears, such that the position of said abutment surface can be adjusted relative to said mobile (222, 242).
Method for the intermittent coating of a moving surface with a paste which contains electrochemically active particles, by using a nozzle having a slot-shaped delivery opening, the paste being supplied to the delivery opening from a paste reservoir via a transport channel and the paste supply to the delivery opening being regulated by a control means which enables the paste supply to the delivery opening in a first switching position and, in a second switching position, blocks the transport channel and disconnects a section of the transport channel extending as far as the delivery opening from the paste supply, wherein a reduced pressure is applied to the section of the transport channel disconnected from the paste supply when the control means is in the second switching position, characterized in that the control means is formed in such a way that it connects the disconnected part of the transport channel to a reduced pressure source in the second switching position.
A device for removing a blocking material in a quenched ash extractor drain pipe of an incineration system allowing hot water to drain from a quenched ash extractor, comprising: a pipe; a connecting part configured to connect the pipe to a gate valve of the quenched ash extractor drain pipe; a ram with a first end configured to break the blocking material and to be slidably guided through the pipe into the quenched ash extractor drain pipe, the ram comprising a spike at the first end; and evacuation means configured to allow the evacuation of said broken blocking material from said quenched ash extractor drain pipe, characterized in that the spike is surrounded by a cutting means. a pipe; a connecting part configured to connect the pipe to a gate valve of the quenched ash extractor drain pipe; a ram with a first end configured to break the blocking material and to be slidably guided through the pipe into the quenched ash extractor drain pipe, the ram comprising a spike at the first end; and evacuation means configured to allow the evacuation of said broken blocking material from said quenched ash extractor drain pipe, characterized in that the spike is surrounded by a cutting means.
A method for predicting the response of a patient diagnosed with melanoma cancer, to an immunotherapeutic antibody directed against CTLA-4, comprising the steps of: (a) measuring the phosphatase activity of a sample, obtained from said patient diagnosed with melanoma, by contacting said sample with at least one protein phosphatase substrate, thereby providing a phosphorylation profile of said sample, said phosphorylation profile comprising the phosphorylation levels of phosphorylation sites present in at least the peptide markers as defined by SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145, SEQ ID NO: 146, SEQ ID NO: 147 and SEQ ID NO: 148; wherein said sample is obtained from a blood sample of said patient diagnosed with melanoma; and, (b) determining from said phosphorylation profile the response of said patient to said immunotherapeutic antibody directed against CTLA-4. (a) measuring the phosphatase activity of a sample, obtained from said patient diagnosed with melanoma, by contacting said sample with at least one protein phosphatase substrate, thereby providing a phosphorylation profile of said sample, said phosphorylation profile comprising the phosphorylation levels of phosphorylation sites present in at least the peptide markers as defined by SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145, SEQ ID NO: 146, SEQ ID NO: 147 and SEQ ID NO: 148; wherein said sample is obtained from a blood sample of said patient diagnosed with melanoma; and, (b) determining from said phosphorylation profile the response of said patient to said immunotherapeutic antibody directed against CTLA-4.