An atherectomy device, comprising: a handle configured to be manipulated by a user; a catheter comprising: an outer sheath comprising: a proximal portion coupled to and extending distally relative to the handle, the proximal portion defining a longitudinal axis of the catheter; a distal portion coupled to and extending distally relative to the proximal portion, the distal portion normally having a curved configuration and being offset from the longitudinal axis, and the distal portion comprising a pattern of slits and non-slit portions or a pattern of kerfs and non-kerf portions; a drive shaft carried within and rotatable relative to the outer sheath; and a cutter assembly coupled to and extending distally relative to the distal portion of the outer sheath, the cutter assembly including a cutter being translatably fixed relative to the outer sheath, the cutter coupled to the drive shaft and rotated about a cutter rotation axis upon rotation of the drive shaft relative to the outer sheath, the cutter rotation axis normally being disposed at an acute angle relative to the longitudinal axis; wherein the curved configuration comprises a proximal curve and distal curve; and wherein the proximal curve bends away from the longitudinal axis and the distal curve bends toward the longitudinal axis. a handle configured to be manipulated by a user; a catheter comprising: an outer sheath comprising: a proximal portion coupled to and extending distally relative to the handle, the proximal portion defining a longitudinal axis of the catheter; a distal portion coupled to and extending distally relative to the proximal portion, the distal portion normally having a curved configuration and being offset from the longitudinal axis, and the distal portion comprising a pattern of slits and non-slit portions or a pattern of kerfs and non-kerf portions; a drive shaft carried within and rotatable relative to the outer sheath; and a cutter assembly coupled to and extending distally relative to the distal portion of the outer sheath, the cutter assembly including a cutter being translatably fixed relative to the outer sheath, the cutter coupled to the drive shaft and rotated about a cutter rotation axis upon rotation of the drive shaft relative to the outer sheath, the cutter rotation axis normally being disposed at an acute angle relative to the longitudinal axis; wherein the curved configuration comprises a proximal curve and distal curve; and wherein the proximal curve bends away from the longitudinal axis and the distal curve bends toward the longitudinal axis. an outer sheath comprising: a proximal portion coupled to and extending distally relative to the handle, the proximal portion defining a longitudinal axis of the catheter; a distal portion coupled to and extending distally relative to the proximal portion, the distal portion normally having a curved configuration and being offset from the longitudinal axis, and the distal portion comprising a pattern of slits and non-slit portions or a pattern of kerfs and non-kerf portions; a proximal portion coupled to and extending distally relative to the handle, the proximal portion defining a longitudinal axis of the catheter; a distal portion coupled to and extending distally relative to the proximal portion, the distal portion normally having a curved configuration and being offset from the longitudinal axis, and the distal portion comprising a pattern of slits and non-slit portions or a pattern of kerfs and non-kerf portions; a drive shaft carried within and rotatable relative to the outer sheath; and a cutter assembly coupled to and extending distally relative to the distal portion of the outer sheath, the cutter assembly including a cutter being translatably fixed relative to the outer sheath, the cutter coupled to the drive shaft and rotated about a cutter rotation axis upon rotation of the drive shaft relative to the outer sheath, the cutter rotation axis normally being disposed at an acute angle relative to the longitudinal axis; wherein the curved configuration comprises a proximal curve and distal curve; and wherein the proximal curve bends away from the longitudinal axis and the distal curve bends toward the longitudinal axis.