A compound of formula wherein R1 is selected from the group consisting of: H, C1-3alkyl, -SC1-6alkyl, -OC1-6alkyl, NRaRb, hydroxy, - SH, NH-NH 2, C3-6cycloalkyl, C4-6heterocycloalkyl, -SO 2 Ph, -OPh, -SPh, -SO 2 (C1-3alkyl), -O(-C1-3alkyl(aryl)), and phenyl; wherein C3-6cycloalkyl, C4-6heterocycloalkyl, O(-C1-3alkyl(aryl)), and phenyl groups may be substituted with one to five substituents selected from the group consisting of: hydrogen, halogen, C1-C6alkyl, amino, trifluoromethyl, carboxylic acid, C3-C7cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl are optionally substituted with one to three groups independently selected from halogen and C1-3alkyl; R2 is H or C1-3alkyl; R3 is selected from the group consisting of: C1-6alkyl, C3-7cycloalkyl, C4-6heterocycloalkyl, alkylcarboxy, aryl, -C1-3alkyl(aryl), and heteroaryl; wherein C3-7cycloalkyl, C4-6heterocycloalkyl, aryl, -C1-3alkyl(aryl), and heteroaryl groups may be substituted with one to five substituents selected from the group consisting of: hydrogen, halogen, C1-C6alkyl, amino, trifluoromethyl, carboxylic acid, C3-C7cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl are optionally substituted with one to three groups independently selected from halogen and C1-3alkyl; each R4 is independently selected from the group consisting of: C1-3alkyl, alkoxy, amide, and ester; n is 0-2; m is 0-3; and Ra and Rb are each independently H, or C1-3alkyl; wherein any alkyl as used herein including alkyl chains defined by the term "-(CH 2) n ", "-(CH 2) m " maybe linear or branched, saturated or unsaturated, unsubstituted or substituted with one to four substituents selected from the group consisting of: halogen, trifluoromethyl, alkylcarboxy, amino, substituted amino, cyano, hydroxy, alkoxy, alkylthio, aryloxy, acyloxy, acyl, acylamino, phosphonate, phosphonic acid, ester, carboxylic acid and nitro; or a pharmaceutically acceptable salt thereof. R1 is selected from the group consisting of: H, C1-3alkyl, -SC1-6alkyl, -OC1-6alkyl, NRaRb, hydroxy, - SH, NH-NH 2, C3-6cycloalkyl, C4-6heterocycloalkyl, -SO 2 Ph, -OPh, -SPh, -SO 2 (C1-3alkyl), -O(-C1-3alkyl(aryl)), and phenyl; wherein C3-6cycloalkyl, C4-6heterocycloalkyl, O(-C1-3alkyl(aryl)), and phenyl groups may be substituted with one to five substituents selected from the group consisting of: hydrogen, halogen, C1-C6alkyl, amino, trifluoromethyl, carboxylic acid, C3-C7cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl are optionally substituted with one to three groups independently selected from halogen and C1-3alkyl; R2 is H or C1-3alkyl; R3 is selected from the group consisting of: C1-6alkyl, C3-7cycloalkyl, C4-6heterocycloalkyl, alkylcarboxy, aryl, -C1-3alkyl(aryl), and heteroaryl; wherein C3-7cycloalkyl, C4-6heterocycloalkyl, aryl, -C1-3alkyl(aryl), and heteroaryl groups may be substituted with one to five substituents selected from the group consisting of: hydrogen, halogen, C1-C6alkyl, amino, trifluoromethyl, carboxylic acid, C3-C7cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl are optionally substituted with one to three groups independently selected from halogen and C1-3alkyl; each R4 is independently selected from the group consisting of: C1-3alkyl, alkoxy, amide, and ester; n is 0-2; m is 0-3; and Ra and Rb are each independently H, or C1-3alkyl;