An isolated anti IL-6 antibody with fully human frameworks and constant regions, which comprises: (i) a light chain variable region, comprising a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:3, a CDRL2 amino acid sequence of SEQ ID NO:21, a CDRL3 amino acid sequence of SEQ ID NO:29, and a heavy chain variable region, comprising a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:39, a CDRH2 amino acid sequence of SEQ ID NO:59, and a CDRH3 amino acid sequence of SEQ ID NO:89; or (ii) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:3, the CDRL2 comprises the amino acid sequence of SEQ ID NO:21, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:41, the CDRH2 comprises the amino acid sequence of SEQ ID NO:75, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:89; or (iii) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:15, the CDRL2 comprises the amino acid sequence of SEQ ID NO:27, the CDRL3 comprises the amino acid sequence of SEQ ID NO:35, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:47, the CDRH2 comprises the amino acid sequence of SEQ ID NO:57, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:91; or (iv) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:15, the CDRL2 comprises the amino acid sequence of SEQ ID NO:17, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:45, the CDRH2 comprises the amino acid sequence of SEQ ID NO:59, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:89; or (v) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:7, the CDRL2 comprises the amino acid sequence of SEQ ID NO:21, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:41, the CDRH2 comprises the amino acid sequence of SEQ ID NO:75, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:87, wherein said antibody binds to human IL-6 or a fragment thereof with an affinity of 0.1-9.9 x 10 -14 M as determined by the Kinexa® method. (i) a light chain variable region, comprising a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:3, a CDRL2 amino acid sequence of SEQ ID NO:21, a CDRL3 amino acid sequence of SEQ ID NO:29, and a heavy chain variable region, comprising a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:39, a CDRH2 amino acid sequence of SEQ ID NO:59, and a CDRH3 amino acid sequence of SEQ ID NO:89; or (ii) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:3, the CDRL2 comprises the amino acid sequence of SEQ ID NO:21, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:41, the CDRH2 comprises the amino acid sequence of SEQ ID NO:75, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:89; or (iii) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:15, the CDRL2 comprises the amino acid sequence of SEQ ID NO:27, the CDRL3 comprises the amino acid sequence of SEQ ID NO:35, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:47, the CDRH2 comprises the amino acid sequence of SEQ ID NO:57, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:91; or (iv) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:15, the CDRL2 comprises the amino acid sequence of SEQ ID NO:17, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:45, the CDRH2 comprises the amino acid sequence of SEQ ID NO:59, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:89; or (v) a light chain variable region, wherein the CDRL1 comprises the amino acid sequence of SEQ ID NO:7, the CDRL2 comprises the amino acid sequence of SEQ ID NO:21, the CDRL3 comprises the amino acid sequence of SEQ ID NO:29, and a heavy chain variable region wherein the CDRH1 comprises the amino acid sequence of SEQ ID NO:41, the CDRH2 comprises the amino acid sequence of SEQ ID NO:75, and the CDRH3 comprises the amino acid sequence of SEQ ID NO:87,