A system (10; 100; 800) for aspirating thrombus and delivering an agent comprising: an aspiration catheter (915; 934; 950; 1050; 1200; 1216; 1236; 1256; 1656) having an aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) and a supply tube (923; 937; 953; 1053; 1204; 1222; 1242; 1262; 1662) having a proximal end, a distal end, and a supply lumen (924; 938; 954; 1054; 1206; 1224; 1244; 1264; 1664), the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) having a proximal end, an open distal end, and an interior wall surface adjacent the open distal end; and at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) at or adjacent the distal end of the supply lumen (924; 938; 954; 1053; 1204; 1222; 1242; 1262; 1662), in fluid communication with the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660), the at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) located proximally of the open distal end of the aspiration lumen (922; 936; 952; 1054; 1206; 1224; 1244; 1264; 1664), wherein the at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) is configured to create a spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) when pressurized fluid is pumped through the supply lumen (924; 938; 954; 1054; 1206; 1224; 1244; 1264; 1664) such that at least some of the spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) is caused to impinge on a deflecting element (929; 940; 956; 1072; 1214; 1232; 1252; 1272; 1672) carried within the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) when a distal end of the aspiration catheter (915; 934; 950; 1050; 1200; 1216; 1236; 1256; 1656) is immersed within an aqueous environment, and such that the at least some of the spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) upon impinging on the deflecting element (929; 940; 956; 1072; 1214; 1232; 1252; 1272; 1672) is caused to deflect, transforming into at least a substantially distally-oriented flow capable of exiting the open distal end of the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660). an aspiration catheter (915; 934; 950; 1050; 1200; 1216; 1236; 1256; 1656) having an aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) and a supply tube (923; 937; 953; 1053; 1204; 1222; 1242; 1262; 1662) having a proximal end, a distal end, and a supply lumen (924; 938; 954; 1054; 1206; 1224; 1244; 1264; 1664), the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) having a proximal end, an open distal end, and an interior wall surface adjacent the open distal end; and at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) at or adjacent the distal end of the supply lumen (924; 938; 954; 1053; 1204; 1222; 1242; 1262; 1662), in fluid communication with the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660), the at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) located proximally of the open distal end of the aspiration lumen (922; 936; 952; 1054; 1206; 1224; 1244; 1264; 1664), wherein the at least one orifice (928; 949; 962; 1058; 1210; 1228; 1248; 1268; 1668) is configured to create a spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) when pressurized fluid is pumped through the supply lumen (924; 938; 954; 1054; 1206; 1224; 1244; 1264; 1664) such that at least some of the spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) is caused to impinge on a deflecting element (929; 940; 956; 1072; 1214; 1232; 1252; 1272; 1672) carried within the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660) when a distal end of the aspiration catheter (915; 934; 950; 1050; 1200; 1216; 1236; 1256; 1656) is immersed within an aqueous environment, and such that the at least some of the spray pattern (919; 947; 960; 1060; 1212; 1230; 1250; 1270; 1670) upon impinging on the deflecting element (929; 940; 956; 1072; 1214; 1232; 1252; 1272; 1672) is caused to deflect, transforming into at least a substantially distally-oriented flow capable of exiting the open distal end of the aspiration lumen (922; 936; 952; 1052; 1203; 1220; 1240; 1260; 1660).