A communication system comprising: a power amplifier configured to amplify an input signal to generate an amplified output signal and provide the amplified output signal to an antenna; a power supply coupled to the power amplifier and configured to provide power to the power amplifier based on a power supply control signal; and a controller coupled to the power supply and configured to: identify a target transmit power level for transmission of a wireless signal; identify at least one characteristic of a baseband signal to be transmitted by the communication system, the wireless signal being based on the baseband signal; generate the power supply control signal based on the target transmit power level and the identified at least one characteristic of the baseband signal using a first relationship between the target transmit power level and at least one setting of the power supply and a second relationship between the identified at least one characteristic of the baseband signal and the at least one setting of the power supply; generate performance information indicative of at least one characteristic of the communication system when the wireless signal is transmitted, wherein the performance information includes at least one of: a voltage headroom of the power amplifier when the wireless signal is transmitted and an output power of the power amplifier when the wireless signal is transmitted; and update the first relationship using the performance information. a power amplifier configured to amplify an input signal to generate an amplified output signal and provide the amplified output signal to an antenna; a power supply coupled to the power amplifier and configured to provide power to the power amplifier based on a power supply control signal; and a controller coupled to the power supply and configured to: identify a target transmit power level for transmission of a wireless signal; identify at least one characteristic of a baseband signal to be transmitted by the communication system, the wireless signal being based on the baseband signal; generate the power supply control signal based on the target transmit power level and the identified at least one characteristic of the baseband signal using a first relationship between the target transmit power level and at least one setting of the power supply and a second relationship between the identified at least one characteristic of the baseband signal and the at least one setting of the power supply; generate performance information indicative of at least one characteristic of the communication system when the wireless signal is transmitted, wherein the performance information includes at least one of: a voltage headroom of the power amplifier when the wireless signal is transmitted and an output power of the power amplifier when the wireless signal is transmitted; and update the first relationship using the performance information. identify a target transmit power level for transmission of a wireless signal; identify at least one characteristic of a baseband signal to be transmitted by the communication system, the wireless signal being based on the baseband signal; generate the power supply control signal based on the target transmit power level and the identified at least one characteristic of the baseband signal using a first relationship between the target transmit power level and at least one setting of the power supply and a second relationship between the identified at least one characteristic of the baseband signal and the at least one setting of the power supply; generate performance information indicative of at least one characteristic of the communication system when the wireless signal is transmitted, wherein the performance information includes at least one of: a voltage headroom of the power amplifier when the wireless signal is transmitted and an output power of the power amplifier when the wireless signal is transmitted; and update the first relationship using the performance information.