An acceptable pharmaceutical composition containing a therapeutically effective amount of one or more D-serine transporter inhibitor compounds for use in a method for the treatment of central nervous system disorders caused by a deficit in N-methyl -D-aspartate receptor function where said one or more D-serine transporter inhibitor compound is selected from L-gamma-glutamyl-4-nitroanilide, L-4-fluorophenylglycine, trans-4-hydroxy-L-proline and R-gamma-2,4-dichlorobenzyl-L-proline and wherein the nervous system disorder is schizophrenia, schizophreniform disorder, and schizoaffective disorder and specifically conditions selected from the following: conduct disorder, solitary aggressive type, conduct disorder, undifferentiated type, tourette's disorder, chronic motor or vocal tic disorder, transient tic disorder, tic disorder, alcohol withdrawal, delirium, alcohol hallucinosis, alcohol dementia associated with alcoholism, amphetamine or similarly acting sympathomimetic intoxication, amphetamine or similarly acting sympathomimetic delirium, amphetamine or similarly acting sympathomimetic delusional disorder, cannabis delusional disorder, cocaine intoxication, cocaine delirium, cocaine delusional disorder, hallucinogen hallucinosis, hallucinogen delusional disorder, hallucinogen mood disorder, hallucinogen post-hallucinogen perception disorder, phencyclidine or similarly acting arylcyclohexylamine intoxication, phencyclidine or similarly acting arylcyclohexylamine delirium, phencyclidine or similarly acting arylcyclohexylamine delusional disorder, phencyclidine or similarly acting arylcyclohexylamine mood disorder, phencyclidine or similarly acting arylcyclohexyilamine organic mental disorder, other or unspecified psychoactive substance intoxication, other or unspecified psychoactive substance delirium, other or unspecified psychoactive substance dementia, other or unspecified psychoactive substance delusional disorder, other or unspecified psychoactive substance hallucinosis, other or unspecified psychoactive substance mood disorder, other or unspecified psychoactive substance anxiety disorder, other or unspecified psychoactive substance personality disorder, other or unspecified psychoactive substance organic mental disorder, delirium, dementia, organic delusional disorder, organic hallucinosis, organic mood disorder, organic anxiety disorder, organic personality disorder, organic mental disorder, obsessive compulsive disorder, post-traumatic stress disorder, generalized anxiety disorder, anxiety disorder, body dysmorphic disorder, hypo-chondriasis (or hypochondriacal neurosis), somatization disorder, undifferentiated somatoform disorder, somatoform disorder, intermittent explosive disorder, kleptomania, pathological gambling, pyromania, trichotillomania, and impulse control disorder, schizophrenia, catatonic, subchronic, schizophrenia, catatonic, chronic, schizophrenia, catatonic, sub chronic with acute exacerbation, schizophrenia, catatonic, chronic with acute exacerbation, schizophrenia, catatonic, in remission, schizophrenia, catatonic, unspecified, schizophrenia, disorganized, subchronic, schizophrenia, disorganized, chronic, schizophrenia, disorganized, subchronic with acute exacerbation, schizophrenia, disorganized, chronic with acute exacerbation, schizophrenia, disorganized, in remission, schizophrenia, disorganized, unspecified, schizophrenia, paranoid, subchronic, schizophrenia, paranoid, chronic, schizophrenia, paranoid, subchronic with acute exacerbation, schizophrenia, paranoid, chronic with acute exacerbation, schizophrenia, paranoid, in remission, schizophrenia, paranoid, unspecified, schizophrenia, undifferentiated, subchronic, schizophrenia, undifferentiated, chronic, schizophrenia, undifferentiated, subchronic with acute exacerbation, schizophrenia, undifferentiated, chronic with acute exacerbation, schizophrenia, undifferentiated, in remission, schizophrenia, undifferentiated, unspecified, schizophrenia, residual, subchronic, schizophrenia, residual, chronic, schizophrenia, residual, subchronic with acute exacerbation, schizophrenia, residual, chronic with acute exacerbation, schizophrenia, residual, in remission, schizophrenia, residual, subchronic, schizophrenia, residual, chronic, schizophrenia, residual, subchronic with acute exacerbation, schizophrenia, residual, chronic with acute exacerbation, schizophrenia, residual, in remission, schizophrenia, residual, unspecified, delusional (paranoid) disorder, brief reactive psychosis schizophrenia form disorder, induced psychotic disorder, psychotic disorder (atypical psychosis), personality disorders, paranoid, personality disorders, schizoid personality disorders, schizotypal personality disorders, antisocial and personality disorders borderline.