A compound of Formula I where: R 1 is N(R 6)(R 7); R 2 is hydrogen, halo, or alkyl; R 3 is alkyl, cycloalkyl, or Ar 1; R 4 is alkyl or haloalkyl; R 5 is alkyl; R 6 is hydrogen, alkyl, haloalkyl, (cycloalkyl)alkyl, (Ar 2)alkyl, cycloalkyl, (alkyl)cycloalkyl, (Ar 2)cycloalkyl, (alkyl)CO, (haloalkyl)CO, ((cycloalkyl)alkyl)CO, (Ar 2)CO, ((Ar 2)alkyl)CO, ((Ar 2)alkyl)OCO, ((Ar 2)alkyl)NHCO, or ((Ar 2)alkyl)COCO; or R 6 is ((trialkylsilyl)alkyl)OCO, (benzyloxy)alkylCO, (phenoxyalkyl)CO, (isoindolinedionyl)alkyl)CO, (((dialkyl)cycloalkoxy)alkyl)CO, (phenoxyalkyl)CO, or (dihalobenzodioxolyl)CO; R 7 is hydrogen or alkyl; or N(R 6)(R 7) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, or haloalkoxy; and Ar 1 is phenyl, pyridinyl, indanyl, naphthyl, tetrahydronaphthalenyl, benzofuranyl, dihydrobenzofuranyl, benzodioxyl, chromanyl, isochromanyl, benzodioxanyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, dihydrobenzoxazinyl, indolyl, dihydroindolyl, benzthiazolyl, or benzothiazolyl, and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, hydroxy, alkoxy, haloalkoxy, phenoxy, benzyloxy, thioalkyl, and acetamido; or Ar 1 is or Ar 2 is phenyl, biphenyl, pyrazolyl, indolyl, or fluorenonyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, benzyloxy, and haloalkoxy; or a pharmaceutically acceptable salt thereof. R 1 is N(R 6)(R 7); R 2 is hydrogen, halo, or alkyl; R 3 is alkyl, cycloalkyl, or Ar 1; R 4 is alkyl or haloalkyl; R 5 is alkyl; R 6 is hydrogen, alkyl, haloalkyl, (cycloalkyl)alkyl, (Ar 2)alkyl, cycloalkyl, (alkyl)cycloalkyl, (Ar 2)cycloalkyl, (alkyl)CO, (haloalkyl)CO, ((cycloalkyl)alkyl)CO, (Ar 2)CO, ((Ar 2)alkyl)CO, ((Ar 2)alkyl)OCO, ((Ar 2)alkyl)NHCO, or ((Ar 2)alkyl)COCO; or R 6 is ((trialkylsilyl)alkyl)OCO, (benzyloxy)alkylCO, (phenoxyalkyl)CO, (isoindolinedionyl)alkyl)CO, (((dialkyl)cycloalkoxy)alkyl)CO, (phenoxyalkyl)CO, or (dihalobenzodioxolyl)CO; R 7 is hydrogen or alkyl; or N(R 6)(R 7) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, or haloalkoxy; and Ar 1 is phenyl, pyridinyl, indanyl, naphthyl, tetrahydronaphthalenyl, benzofuranyl, dihydrobenzofuranyl, benzodioxyl, chromanyl, isochromanyl, benzodioxanyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, dihydrobenzoxazinyl, indolyl, dihydroindolyl, benzthiazolyl, or benzothiazolyl, and is substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, hydroxy, alkoxy, haloalkoxy, phenoxy, benzyloxy, thioalkyl, and acetamido; or Ar 1 is or Ar 2 is phenyl, biphenyl, pyrazolyl, indolyl, or fluorenonyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, benzyloxy, and haloalkoxy;