mhurhangee/ep-ind-claims huggingface dataset:
A method for selecting an antibody on the basis of its ability to be internalized into a cell, said method comprising the steps of a) providing a plurality of antibodies to be tested for internalization, wherein each of said antibodies is provided as a separate sample, and wherein said antibodies bind the same antigen, b) providing eukaryotic cells expressing the antigen to which said antibodies bind, c) providing a Fab fragment capable of binding said antibodies, wherein said Fab fragment i) does not mediate internalization, and ii) comprises a fluorescent label, d) incubating said samples, cells and Fab fragment in a test vial under conditions that allow formation and internalization of a complex comprising said antigen, antibody and Fab fragment, e) detecting fluorescence of at least a cell-containing subvolume of said test vial, and f) selecting an antibody on the basis of the outcome of the detection. a) providing a plurality of antibodies to be tested for internalization, wherein each of said antibodies is provided as a separate sample, and wherein said antibodies bind the same antigen, b) providing eukaryotic cells expressing the antigen to which said antibodies bind, c) providing a Fab fragment capable of binding said antibodies, wherein said Fab fragment i) does not mediate internalization, and ii) comprises a fluorescent label, d) incubating said samples, cells and Fab fragment in a test vial under conditions that allow formation and internalization of a complex comprising said antigen, antibody and Fab fragment, e) detecting fluorescence of at least a cell-containing subvolume of said test vial, and f) selecting an antibody on the basis of the outcome of the detection.
A rechargeable battery, comprising: at least one electrode assembly that performs charging and discharging; a case receiving the electrode assembly including a positive electrode, a negative electrode and a separator interposed between; a cap assembly coupled to the case and including at least one terminal electrically connected to the electrode assembly; a lead tab electrically connecting the terminal and the electrode assembly, the lead tab including a connection unit, a side plate bent to the connection unit, and at least one coupling bar, wherein the coupling bar includes a welding portion bent to the side plate and coupled to an uncoated region of the electrode through welding, a hook portion protruding away from portions of the uncoated region to which the welding portion is attached, and an insertion tip bent at an end portion of the hook portion and formed parallel to the welding portion; and a supporting member between the lead tab and the case, wherein the supporting member includes a base supported by an inner surface of the case, side end supporting plates protruding from side ends of the base, an upper supporting protrusion and a lower supporting protrusion vertically separated from the upper supporting protrusion and protruding from the base toward the electrode assembly, wherein the hook portion is positioned between the upper supporting protrusion and the lower supporting protrusion. at least one electrode assembly that performs charging and discharging; a case receiving the electrode assembly including a positive electrode, a negative electrode and a separator interposed between; a cap assembly coupled to the case and including at least one terminal electrically connected to the electrode assembly; a lead tab electrically connecting the terminal and the electrode assembly, the lead tab including a connection unit, a side plate bent to the connection unit, and at least one coupling bar, wherein the coupling bar includes a welding portion bent to the side plate and coupled to an uncoated region of the electrode through welding, a hook portion protruding away from portions of the uncoated region to which the welding portion is attached, and an insertion tip bent at an end portion of the hook portion and formed parallel to the welding portion; and a supporting member between the lead tab and the case, wherein the supporting member includes a base supported by an inner surface of the case, side end supporting plates protruding from side ends of the base, an upper supporting protrusion and a lower supporting protrusion vertically separated from the upper supporting protrusion and protruding from the base toward the electrode assembly, wherein the hook portion is positioned between the upper supporting protrusion and the lower supporting protrusion.
A scintillator screen manufacturing method, comprising the following steps: making a crystal column scintillator layer on a predetermined surface of a substrate; making a moisture proof layer with a predetermined thickness on the periphery of the substrate and the crystal column scintillator layer by using a CVD device, wherein the moisture proof layer is a first dichlorodi-p-xylylene film, the substrate is a highly reflective PET substrate, and the crystal column scintillator layer is a crystal column cesium iodide layer; making an X-ray absorption layer on the surface of the moisture-proof layer excluding a surface for receiving X-rays; and making a protective layer on an outer surface of the X-ray absorption layer and on the surface of the moisture-proof layer for receiving X-rays. making a crystal column scintillator layer on a predetermined surface of a substrate; making a moisture proof layer with a predetermined thickness on the periphery of the substrate and the crystal column scintillator layer by using a CVD device, wherein the moisture proof layer is a first dichlorodi-p-xylylene film, the substrate is a highly reflective PET substrate, and the crystal column scintillator layer is a crystal column cesium iodide layer; making an X-ray absorption layer on the surface of the moisture-proof layer excluding a surface for receiving X-rays; and making a protective layer on an outer surface of the X-ray absorption layer and on the surface of the moisture-proof layer for receiving X-rays.
A composition comprising desmopressin for use in the treatment of nocturia or nocturnal polyuria by reducing the number of nocturnal voids and/or by reducing nocturnal urine volume and/or by increasing an initial period of sleep undisturbed by nocturnal voids in a female patient in need thereof, the composition comprising an orodispersible dose of 25 microgram of desmopressin, wherein the dose is measured as the free base of desmopressin, wherein the dose is taken 0.8 to 3 hours prior to the patient's bedtime.
A trimming apparatus for producing a uniform sheared edge on a tubular work piece, the trimming apparatus comprising a collar with a bore adapted to slip over the work piece, the bore having a sharp peripheral edge, a tool with an end sized to fit in the work piece, the tool end having a sharp edge, and a mechanism to develop radial and angular motion of the tool relative to the collar, the tool and collar edges during such radial and angular motion being arranged to shear the tubular work piece to sever a ring therefrom and produce said uniform edge, wherein the mechanism comprises a holder on which the tool is mounted, the holder being arranged to be displaced relative to the axis of the tubular work piece axially and orbitally, characterized in that the mechanism further includes a cam surface for converting axial movement of the holder relative to a support of the holder into radial movement of the holder.
An inhaler suitable for delivery of a medicament in dry powder form from a blister package composed of a plurality of blister pockets each of which comprises medicament in dry powder form and which are spaced at equal intervals, the inhaler comprising: - a mouthpiece enabling the patient to inhale a medicament in dry powder form from an opened blister pocket, - a gear mechanism enabling a blister package to be indexed and the medicament in dry powder form to become ready for inhalation, - a rotatable mouthpiece cover covering the mouthpiece and triggering the gear mechanism, and - a housing situated between an upper housing member and a lower housing member in which the blister package and the gear mechanism are enclosed characterized in that said inhaler comprises stabilizing resilient covers (32, 33) that are connected with the upper and the lower housing members respectively (4a, 4b), and the movement of the mouthpiece cover is hindered by pawls (32a, 33a) under the stabilizing resilient covers (32, 33) on connection points (29, 30) that enable the mouthpiece cover to communicate with the gear mechanism interlock with the mouthpiece cover when the mouthpiece is completely covered by the mouthpiece cover. - a mouthpiece enabling the patient to inhale a medicament in dry powder form from an opened blister pocket, - a gear mechanism enabling a blister package to be indexed and the medicament in dry powder form to become ready for inhalation, - a rotatable mouthpiece cover covering the mouthpiece and triggering the gear mechanism, and - a housing situated between an upper housing member and a lower housing member in which the blister package and the gear mechanism are enclosed
Method of anchoring a transverse force element for connecting building parts to a building part to be constructed from concrete, wherein, during the construction of the building part, a substantially horizontal recess, which recess is provided with undercut regions and is enclosed on all sides perpendicularly to the direction of its extent, is provided in the building part by arranging a corresponding recess former (3, 3') in a formwork for the building part, wherein the recess is provided with at least two substantially vertical filling and venting openings (4, 5) arranged spaced apart from one another and wherein, after the construction of the building part, the transverse force element is introduced into the recess and the recess is filled with a casting compound by way of at least one of the filling and venting openings (4, 5), characterised in that a first of the at least two filling and venting openings is arranged in a terminal region of the recess and a second of the at least two filling and venting openings is arranged in a front region of the recess, and the cavity of the recess that remains around the transverse force element is completely filled with the casting compound.
A method of detecting and evaluating indoor climate data, comprising the following steps: - determining a time independent partial U value for a critical point on a wall inner surface, - determining a dew point, - determining a wall inner temperature at the critical point, and - comparing the wall inner temperature at the critical point with the dew point, the temporal profile of the wall inner temperature at the critical point and the temporal profile of the dew point being defined by the repetitive determination of the wall inner temperature at the critical point or of the dew point at regular or irregular time intervals and being compared with each other, characterized in that the wall inner temperature is determined from an ambient temperature and an outside temperature using the partial U value, wherein for the repetitive determination of the wall inner temperature at the critical point by means of the partial U value, the outside temperatures necessary for the calculation are determined by means of a climatic model which provides geographically associated climate data using a plurality of weather stations and taking at least the orographic altitudes and/or the population densities into account. - determining a time independent partial U value for a critical point on a wall inner surface, - determining a dew point, - determining a wall inner temperature at the critical point, and - comparing the wall inner temperature at the critical point with the dew point,
A turbomachine defining a radial direction and an axial direction, the turbomachine comprising: a turbine section comprising a turbine, the turbine comprising a first plurality of turbine rotor blades and a second plurality of turbine rotor blades, the first plurality of turbine rotor blades and second plurality of turbine rotor blades alternatingly spaced along the axial direction; a gearbox comprising a ring gear, a planet gear, and a sun gear, wherein the first plurality of turbine rotor blades and the second plurality of turbine rotor blades are each coupled to one of the ring gear, the planet gear, or the sun gear such that the first plurality of turbine rotor blades is rotatable with the second plurality of turbine rotor blades through the gearbox; and an electric machine assembly comprising a rotor and a stator, the rotor coupled to one of the ring gear, the planet gear, or the sun gear of the gearbox such that the rotor rotates relative to the stator during operation of the turbomachine; wherein the gearbox further comprises a planet gear carrier, wherein the planet gear defines a local axis and is rotatably coupled to the planet gear carrier such that it is rotatable about its local axis, characterized in that the rotor of the electric machine assembly is coupled to the planet gear such that the rotor is rotatable about the local axis of the planet gear with the planet gear. a turbine section comprising a turbine, the turbine comprising a first plurality of turbine rotor blades and a second plurality of turbine rotor blades, the first plurality of turbine rotor blades and second plurality of turbine rotor blades alternatingly spaced along the axial direction; a gearbox comprising a ring gear, a planet gear, and a sun gear, wherein the first plurality of turbine rotor blades and the second plurality of turbine rotor blades are each coupled to one of the ring gear, the planet gear, or the sun gear such that the first plurality of turbine rotor blades is rotatable with the second plurality of turbine rotor blades through the gearbox; and an electric machine assembly comprising a rotor and a stator, the rotor coupled to one of the ring gear, the planet gear, or the sun gear of the gearbox such that the rotor rotates relative to the stator during operation of the turbomachine; wherein the gearbox further comprises a planet gear carrier, wherein the planet gear defines a local axis and is rotatably coupled to the planet gear carrier such that it is rotatable about its local axis, characterized in that the rotor of the electric machine assembly is coupled to the planet gear such that the rotor is rotatable about the local axis of the planet gear with the planet gear.
A toy assembly, comprising: a housing; and an inner object inside the housing, wherein the inner object includes a breakout mechanism that is operable to break the housing to expose the inner object, wherein the breakout mechanism includes a hammer, characterized in that the hammer is actuated by an actuation lever, and the breakout mechanism further includes a hammer biasing structure, wherein the hammer biasing structure includes a pivot arm pivotally connected to the actuation lever and a pivot arm biasing member that acts between the pivot arm and the actuation lever to urge the pivot arm into the hammer to urge the hammer towards an extended position, wherein the hammer is not locked in the extended position, so as to reduce a risk of a poking injury to a user of the toy assembly. a housing; and an inner object inside the housing, wherein the inner object includes a breakout mechanism that is operable to break the housing to expose the inner object, wherein the breakout mechanism includes a hammer,
Use of a trace element solution to supplement a mono substrate of vegetable biomass from the agricultural production or mixtures of different vegetable substrates with nutriments for an anaerobic fermentation of biogas, comprising at least one trace element other than Fe 3+ from the group consisting of iron, nickel, cobalt, selenium, tungsten, lead, copper, cadmium, molybdenum, vanadium, manganese, boron and zinc and at least two complexing agents with different affinities for metal ions, wherein - the complexing agents are present in an amount at least equimolar to the trace elements; - the first complexing agent is a tertiary a mine and has a constant of complex formation (pK) for Fe 3+ of at least pK = 10, - a second complexing agent has a constant of complex formation of at least pK = 5 for at least one metal ion of the trace element solution other than Fe 3+ and the constant of complex formation for Fe 3+ of the second complexing agent is inferior to the constant of complex formation for Fe 3+ of the first complexing agent. - the complexing agents are present in an amount at least equimolar to the trace elements; - the first complexing agent is a tertiary a mine and has a constant of complex formation (pK) for Fe 3+ of at least pK = 10, - a second complexing agent has a constant of complex formation of at least pK = 5 for at least one metal ion of the trace element solution other than Fe 3+ and the constant of complex formation for Fe 3+ of the second complexing agent is inferior to the constant of complex formation for Fe 3+ of the first complexing agent.
A device for irradiating tissue with light pulses, comprising a housing, at least one light source for emitting the light pulses, a modulator and a power stage for generating the light pulses, and with an activating element, wherein the power stage for generating the light pulses has a peak power density (p̂) of ≥ 50 mW/cm 2, based on a pulse duty factor (ΔT/T), and wherein the at least one light source is formed by at least one light-emitting diode, characterised in that the device is adapted to emit light pulses of a single peak wavelength (λ) of from 600 nm to 660 nm, in that the modulator for generating the light pulses has a pulse frequency (f) of from 1 to 10 Hz, such as to allow for a removal of destroyed cells or cell parts via the blood, and in that the energy of the light pulses causes frequency doubling of the light pulses in the irradiated tissue.
A gasket for arrangement and sealing between adjacent first and second heat transfer plates in a plate heat exchanger, which gasket comprises an annular gasket portion arranged to enclose a port hole of the first heat transfer plate, an inner edge of the annular gasket portion defining an area including a reference point coinciding with a center point of a biggest imaginary circle that can be fitted within the area, cha racterized in that the area has a form defined by a number of corner points of an imaginary plane geometric figure of which at least one is displaced from an arc of the circle, and the same number of curved lines (74, 76, 78) having no straight parts and connecting the corner points, wherein a first corner point of the corner points is arranged on a first distance from the reference point, a second one of the corner points is arranged closest to the first corner point in a clockwise direction and on a second distance from the reference point and a third one of the corner points is arranged closest to the first corner point in a counter clockwise direction and on a third distance from the reference point, the area having one symmetry axis (s) only which extends through the first corner point and the reference point.
A heat-ray shielding particle dispersion which contains indium tin oxide particles having a heat-ray shielding capability, a solvent containing 60% by mass or more of water and a dispersant, the ITO particles have a BET specific surface area of 20 m 2 /g or more and 75 m 2 /g or less, have a blue or dark blue tone represented by an L value of 50 or less, a<0 and b<0 in an Lab color system, and are contained in an amount of 1-90% by mass with respect to 100% by mass of the dispersion, the solvent is a component obtained by removing the heating residue from the heat-ray shielding particle dispersion, and is contained in an amount of 6.1-99.0% by mass with respect to 100% by mass of the dispersion, the dispersant is one kind or two or more kinds of dispersants selected from the group consisting of a phosphate ester-based dispersant, a polyglycerin-based dispersant, a polyvinylpyrrolidone-based dispersant, and a polyacrylate-based dispersant, wherein the dispersant is a water-soluble dispersant and a content of an active ingredient(s) of the dispersant is 0.05-80 parts by mass with respect to 100 parts by mass of the ITO particles. the ITO particles have a BET specific surface area of 20 m 2 /g or more and 75 m 2 /g or less, have a blue or dark blue tone represented by an L value of 50 or less, a<0 and b<0 in an Lab color system, and are contained in an amount of 1-90% by mass with respect to 100% by mass of the dispersion, the solvent is a component obtained by removing the heating residue from the heat-ray shielding particle dispersion, and is contained in an amount of 6.1-99.0% by mass with respect to 100% by mass of the dispersion, the dispersant is one kind or two or more kinds of dispersants selected from the group consisting of a phosphate ester-based dispersant, a polyglycerin-based dispersant, a polyvinylpyrrolidone-based dispersant, and a polyacrylate-based dispersant, wherein the dispersant is a water-soluble dispersant and a content of an active ingredient(s) of the dispersant is 0.05-80 parts by mass with respect to 100 parts by mass of the ITO particles.
A polyurethane coating composition which is a two component composition comprising: a) an isocyanate component comprising an aliphatic isocyanate and an aromatic isocyanate, and b) a polyol component comprising an acrylic polyol and a polyester polyol wherein the coating composition cures at room temperature. a) an isocyanate component comprising an aliphatic isocyanate and an aromatic isocyanate, and b) a polyol component comprising an acrylic polyol and a polyester polyol wherein the coating composition cures at room temperature.
A flue gas recirculation combustor comprising: a combustor chamber configured to receive fuel and combustion gas to cause combustion, the combustor chamber including a nozzle-side end and a combustor outlet; a nozzle can connected to the nozzle-side end of the combustor chamber; a plurality of nozzles disposed in the nozzle can and arranged such that an injection direction thereof is directed to a side of the combustor chamber; and a sleeve disposed in a premixing space defined between the nozzle can and the nozzle-side end of the combustor chamber, the sleeve including a recirculation pathway to recirculate combustion air from the combustor chamber to the premixing space, characterized in that the recirculation pathway includes an ejector nozzle, wherein the ejector nozzle includes a nozzle casing, an injection control needle assembly disposed in the nozzle casing, a combustor flow path connecting at least one point of the nozzle casing and the nozzle-side end of the combustor chamber, and a premix flow path connecting a side of the nozzle casing and the premixing space. a combustor chamber configured to receive fuel and combustion gas to cause combustion, the combustor chamber including a nozzle-side end and a combustor outlet; a nozzle can connected to the nozzle-side end of the combustor chamber; a plurality of nozzles disposed in the nozzle can and arranged such that an injection direction thereof is directed to a side of the combustor chamber; and a sleeve disposed in a premixing space defined between the nozzle can and the nozzle-side end of the combustor chamber, the sleeve including a recirculation pathway to recirculate combustion air from the combustor chamber to the premixing space, characterized in that the recirculation pathway includes an ejector nozzle, wherein the ejector nozzle includes a nozzle casing, an injection control needle assembly disposed in the nozzle casing, a combustor flow path connecting at least one point of the nozzle casing and the nozzle-side end of the combustor chamber, and a premix flow path connecting a side of the nozzle casing and the premixing space.