A compound of Formula II: a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, and/or combination thereof; wherein: X is S; R is selected from H, halo, hydroxyl, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkoxy, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, carboxyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, amino, aminoalkyl, alkylaminoalkyl, heterocyclylalkyl, aralkyl, arylalkenyl, arylalkynyl, alkylthio, alkylamino, arylamino, heteroarylamino, aralkylamino, alkylaminoalkylamino, arylthio, aralkylthio, aryloxy, aralkoxy, heterocyclylalkoxy, heterocyclyloxyalkyl, cycloalkyl, and cycloalkenyl; R 3 is H or substituted or unsubstituted alkyl; R 4 is selected from a substituted or unsubstituted pyridinyl group or a substituted or unsubstituted phenyl group, wherein the pyridinyl group is selected from a 3-pyridinyl group, or a 4-pyridinyl group; and R 6 to R 8 are each independently selected from H, halo, hydroxyl, amino, nitro, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heteroaromatic group, wherein the hydrocarbon group is a chain of 1 to 25 carbon atoms and the heterogeneous group is a saturated or unsaturated chain of non-hydrogen member atoms comprising carbon atoms and at least one heteroatom. X is S; R is selected from H, halo, hydroxyl, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkoxy, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, carboxyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, amino, aminoalkyl, alkylaminoalkyl, heterocyclylalkyl, aralkyl, arylalkenyl, arylalkynyl, alkylthio, alkylamino, arylamino, heteroarylamino, aralkylamino, alkylaminoalkylamino, arylthio, aralkylthio, aryloxy, aralkoxy, heterocyclylalkoxy, heterocyclyloxyalkyl, cycloalkyl, and cycloalkenyl; R 3 is H or substituted or unsubstituted alkyl; R 4 is selected from a substituted or unsubstituted pyridinyl group or a substituted or unsubstituted phenyl group, wherein the pyridinyl group is selected from a 3-pyridinyl group, or a 4-pyridinyl group; and R 6 to R 8 are each independently selected from H, halo, hydroxyl, amino, nitro, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heteroaromatic group, wherein the hydrocarbon group is a chain of 1 to 25 carbon atoms and the heterogeneous group is a saturated or unsaturated chain of non-hydrogen member atoms comprising carbon atoms and at least one heteroatom.