mhurhangee/ep-ind-claims huggingface dataset:
A method of detecting a disease associated with a mutation in a gene, comprising: dividing a test sample of alleles of the gene isolated from a patient, to form a plurality of aliquots of alleles of the gene wherein said aliquots comprise on average between 0 and 20 alleles prior to amplification; amplifying said alleles in said plurality of aliquots to form amplified alleles; transcribing and translating protein in vitro using said amplified alleles as transcription templates; determining size or composition of said proteins, wherein proteins which differ in size or composition from the protein produced by a wild-type allele of the gene indicate a mutation in an amplified allele of the gene which indicates the disease in the patient, where: (a) the gene is CF, and the disease is cystic fibrosis; (b) the gene is Merlin, and the disease is neurofibromatosis type 2; (c) the gene is VHL, and the disease is von Hippel-Landau disease; (d) the gene is hMSH2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); (e) the gene is hMLH1, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); or (f) the gene is hPMS2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC). dividing a test sample of alleles of the gene isolated from a patient, to form a plurality of aliquots of alleles of the gene wherein said aliquots comprise on average between 0 and 20 alleles prior to amplification; amplifying said alleles in said plurality of aliquots to form amplified alleles; transcribing and translating protein in vitro using said amplified alleles as transcription templates; determining size or composition of said proteins, wherein proteins which differ in size or composition from the protein produced by a wild-type allele of the gene indicate a mutation in an amplified allele of the gene which indicates the disease in the patient, where: (a) the gene is CF, and the disease is cystic fibrosis; (b) the gene is Merlin, and the disease is neurofibromatosis type 2; (c) the gene is VHL, and the disease is von Hippel-Landau disease; (d) the gene is hMSH2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); (e) the gene is hMLH1, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); or (f) the gene is hPMS2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC). (a) the gene is CF, and the disease is cystic fibrosis; (b) the gene is Merlin, and the disease is neurofibromatosis type 2; (c) the gene is VHL, and the disease is von Hippel-Landau disease; (d) the gene is hMSH2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); (e) the gene is hMLH1, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC); or (f) the gene is hPMS2, and the disease is Hereditary non-Polyposis Colon Cancer (HNPCC).
A molecular trap suitable for reducing free-hapten interference in an assay, the molecular trap being soluble in an aqueous assay solution, said molecular trap comprising: a molecular cage that comprises a shell that surrounds a cavity having characteristics to selectively capture and retain a hapten that is unconjugated or free in an assay solution, the shell of the molecular cage being selected from the group consisting of a cyclodextrin shell and a molecular-imprint-specific binding partner shell for the hapten, wherein the free-hapten is selected from the group consisting of free-biotin and free-fluorescein; and wherein the molecular cage further comprises a coating on the shell, the coating being selectively permeable to the free-hapten and impermeable to relatively larger assay components present in the assay solution, the relatively larger assay components comprising an assay-conjugate of the hapten, an assay specific binding partner (sbp) for the hapten, an assay-conjugate of the sbp, and other assay molecules of greater than about 1000 Daltons molecular weight, wherein the coating comprises one or more of bovine serum albumin, dextran aldehyde, amino dextran, and an ionically charged moiety. a molecular cage that comprises a shell that surrounds a cavity having characteristics to selectively capture and retain a hapten that is unconjugated or free in an assay solution, the shell of the molecular cage being selected from the group consisting of a cyclodextrin shell and a molecular-imprint-specific binding partner shell for the hapten, wherein the free-hapten is selected from the group consisting of free-biotin and free-fluorescein; and wherein the molecular cage further comprises a coating on the shell, the coating being selectively permeable to the free-hapten and impermeable to relatively larger assay components present in the assay solution, the relatively larger assay components comprising an assay-conjugate of the hapten, an assay specific binding partner (sbp) for the hapten, an assay-conjugate of the sbp, and other assay molecules of greater than about 1000 Daltons molecular weight, wherein the coating comprises one or more of bovine serum albumin, dextran aldehyde, amino dextran, and an ionically charged moiety.
A color wheel for use in an automated luminaire, the color wheel comprising: a transparent substrate; and a patterned dichroic filter coating on the transparent substrate, the pattern including: a first region, comprising unconnected coated dots, most of the coated dots having a substantially equal first size, a density of the coated dots varying from a lower density at a first end of the first region to a higher density at a second end of the first region; and a second region, comprising a contiguous dichroic filter coating that includes unconnected uncoated holes, most of the uncoated holes having a substantially equal second size, a density of the uncoated holes varying from a higher density at a first end of the second region to a lower density at a second end of the second region, the first end of the second region abutting the second end of the first region. a transparent substrate; and a patterned dichroic filter coating on the transparent substrate, the pattern including: a first region, comprising unconnected coated dots, most of the coated dots having a substantially equal first size, a density of the coated dots varying from a lower density at a first end of the first region to a higher density at a second end of the first region; and a second region, comprising a contiguous dichroic filter coating that includes unconnected uncoated holes, most of the uncoated holes having a substantially equal second size, a density of the uncoated holes varying from a higher density at a first end of the second region to a lower density at a second end of the second region, the first end of the second region abutting the second end of the first region. a first region, comprising unconnected coated dots, most of the coated dots having a substantially equal first size, a density of the coated dots varying from a lower density at a first end of the first region to a higher density at a second end of the first region; and a second region, comprising a contiguous dichroic filter coating that includes unconnected uncoated holes, most of the uncoated holes having a substantially equal second size, a density of the uncoated holes varying from a higher density at a first end of the second region to a lower density at a second end of the second region, the first end of the second region abutting the second end of the first region.
A suspension device interposed between a vehicle body and a wheel, provided with a vehicle-body side connecting member connected to a vehicle body side and a pair of front and rear telescopic tube members (2, 3) connected by the vehicle-body side connecting member, the wheel being supported from one side by the pair of tube members (2, 3), wherein the vehicle-body side connecting member comprises: - a body portion, a steering pipe being fixed to the body portion in a standing state, - an arc-shaped support groove (5, 6) formed respectively on front and rear side surfaces of the body portion in a longitudinal direction of the vehicle body, and - a pressing mechanism (7, 8) provided at each of the support grooves (5, 6) and configured to press the corresponding tube member (2, 3) inserted into the corresponding support groove (5, 6) toward a deepest portion (5a, 6a) of the corresponding support groove (5, 6) where the support grooves (5, 6) are the closest to each other, wherein each of the pressing mechanisms (7, 8) includes - an arc-shaped holding portion (70, 80) extending from the body portion and sandwiching the corresponding tube member (2, 3) between the corresponding support groove (5, 6) and itself, - a slit (71, 81) formed between a distal end portion (70a, 80a) of said holding portion (70, 80) and the body portion, and - a bolt (72, 82) configured to narrow a width of said slit (71, 81), respectively, and wherein the slits (71, 81) are arranged on a steering pipe side, characterized in that the bolt of the pressing mechanism on a front side and the bolt of the pressing mechanism on a rear side are arranged symmetrically in the longitudinal direction of the vehicle body, and an angle of intersection (α3, α4) between each of shaft core lines (X4, X5) of the bolt of the pressing mechanism on the front side and the bolt of the pressing mechanism on the rear side and a straight line connecting curvature centers (50, 60) of the support groove on the front side and the support groove on the rear side is within 45 degrees. - a body portion, a steering pipe being fixed to the body portion in a standing state, - an arc-shaped support groove (5, 6) formed respectively on front and rear side surfaces of the body portion in a longitudinal direction of the vehicle body, and - a pressing mechanism (7, 8) provided at each of the support grooves (5, 6) and configured to press the corresponding tube member (2, 3) inserted into the corresponding support groove (5, 6) toward a deepest portion (5a, 6a) of the corresponding support groove (5, 6) where the support grooves (5, 6) are the closest to each other, - an arc-shaped holding portion (70, 80) extending from the body portion and sandwiching the corresponding tube member (2, 3) between the corresponding support groove (5, 6) and itself, - a slit (71, 81) formed between a distal end portion (70a, 80a) of said holding portion (70, 80) and the body portion, and - a bolt (72, 82) configured to narrow a width of said slit (71, 81), respectively, and
A propeller system comprising: a rotatable housing having at least one propeller blade mounted thereon; an electric pitch control motor within the rotatable housing; and a pitch control member coupled to the propeller blade and extending through a wall of the rotatable housing; wherein the pitch control motor is configured to move the pitch control member and to thereby vary the pitch of the propeller blade; wherein the pitch control member extends from the propeller blade, through an elongated slot in the rotatable housing, and to an inner portion; and wherein the propeller system is characterised in that: one or more magnets are arranged on the inner portion of the pitch control member. a rotatable housing having at least one propeller blade mounted thereon; an electric pitch control motor within the rotatable housing; and a pitch control member coupled to the propeller blade and extending through a wall of the rotatable housing; wherein the pitch control motor is configured to move the pitch control member and to thereby vary the pitch of the propeller blade; wherein the pitch control member extends from the propeller blade, through an elongated slot in the rotatable housing, and to an inner portion; and wherein the propeller system is characterised in that: one or more magnets are arranged on the inner portion of the pitch control member.
A radio frequency, RF, signal splitter (38, 180, 260), comprising: a transformer having: a primary winding, for receiving a differential input signal; a first secondary winding (266, 184) having a first port and a second port and configured to generate a first differential output signal; a second secondary winding (264, 186) having a third port and a fourth port and configured to generate a second differential output signal; and a cross-connection (188, 268, 270) electrically connecting said first port of said first secondary winding to said fourth port of said second secondary winding as well as electrically connecting said second port of said first secondary winding to said third port of said second secondary winding. a transformer having: a primary winding, for receiving a differential input signal; a first secondary winding (266, 184) having a first port and a second port and configured to generate a first differential output signal; a second secondary winding (264, 186) having a third port and a fourth port and configured to generate a second differential output signal; and a primary winding, for receiving a differential input signal; a first secondary winding (266, 184) having a first port and a second port and configured to generate a first differential output signal; a second secondary winding (264, 186) having a third port and a fourth port and configured to generate a second differential output signal; and a cross-connection (188, 268, 270) electrically connecting said first port of said first secondary winding to said fourth port of said second secondary winding as well as electrically connecting said second port of said first secondary winding to said third port of said second secondary winding.
An organic light-emitting device containing a host material, a delayed fluorescent material and a light-emitting material satisfying the following expression: E S 1 H > E S 1 F > E S 1 D wherein E S1 represents a lowest excited singlet energy level of the host material, E S1 represents a lowest excited singlet energy level of the delayed fluorescent material, and E S1 represents a lowest excited singlet energy level of the light-emitting material, wherein the organic light-emitting device is an organic semiconductor laser, characterized in that the delayed fluorescent material has an energy difference ΔE st between a lowest excited singlet state and a lowest excited triplet state at 77 K of 0.3 eV or less, energy from an excited singlet state of the host material transfers to the delayed fluorescent material and the light-emitting material, a triplet excited state of the delayed fluorescent material transfers to a singlet excited state of the delayed fluorescent material through reverse intersystem crossing, and the excited singlet energy of the delayed fluorescent material transfers to the light-emitting material. wherein E S1 represents a lowest excited singlet energy level of the host material, E S1 represents a lowest excited singlet energy level of the delayed fluorescent material, and E S1 represents a lowest excited singlet energy level of the light-emitting material, wherein the organic light-emitting device is an organic semiconductor laser, characterized in that the delayed fluorescent material has an energy difference ΔE st between a lowest excited singlet state and a lowest excited triplet state at 77 K of 0.3 eV or less, energy from an excited singlet state of the host material transfers to the delayed fluorescent material and the light-emitting material, a triplet excited state of the delayed fluorescent material transfers to a singlet excited state of the delayed fluorescent material through reverse intersystem crossing, and the excited singlet energy of the delayed fluorescent material transfers to the light-emitting material.
A method for assessing the presence and/or the severity of fibrotic non-alcoholic steatohepatitis (fibrotic NASH) in a subject, wherein said method comprises: - measuring cytokeratin 18 (CK-18), aspartate aminotransferase and Homeostasis model assessment of insulin resistance (HOMA) in a sample of said subject; - combining the three obtained measures in a binary logistic regression to obtain a score value ranging from 0 to 1; and - comparing the score value to at least one predetermined reference value, wherein said predetermined reference value is derived from the determination of the score in one or more subjects who are identified as suffering from non-alcoholic fatty liver disease (NAFLD), NASH, or fibrotic NASH, thereby assessing the presence and/or the severity of fibrotic NASH in the subject. - measuring cytokeratin 18 (CK-18), aspartate aminotransferase and Homeostasis model assessment of insulin resistance (HOMA) in a sample of said subject; - combining the three obtained measures in a binary logistic regression to obtain a score value ranging from 0 to 1; and - comparing the score value to at least one predetermined reference value, wherein said predetermined reference value is derived from the determination of the score in one or more subjects who are identified as suffering from non-alcoholic fatty liver disease (NAFLD), NASH, or fibrotic NASH,
A front body structure in a body which has a front compartment which is arranged at a front side of a passenger compartment, comprising: a pair of front side members which are positioned at the inside of said front compartment and extend in a front-rear direction of said body; a pair of strut towers which are arranged inside said front compartment at the both sides of a width direction of said front compartment and at the inside of which suspensions for front wheel are arranged; and a reinforcing member which is connected to the top part of said strut tower and a front side member which faces said strut tower, and which extends between these top part and front side member, wherein said reinforcing member characterised in further comprising a first reinforcing member which is connected to a top part of a strut tower of one side in the width direction and a front side member of the other side in the width direction and extends between these top part and front side member and a second reinforcing member which is connected to a top part of a strut tower of the other side in the width direction and a front side member of the one side in the width direction and extends between these top part and front side member. a pair of front side members which are positioned at the inside of said front compartment and extend in a front-rear direction of said body; a pair of strut towers which are arranged inside said front compartment at the both sides of a width direction of said front compartment and at the inside of which suspensions for front wheel are arranged; and a reinforcing member which is connected to the top part of said strut tower and a front side member which faces said strut tower, and which extends between these top part and front side member, wherein said reinforcing member characterised in further comprising a first reinforcing member which is connected to a top part of a strut tower of one side in the width direction and a front side member of the other side in the width direction and extends between these top part and front side member and a second reinforcing member which is connected to a top part of a strut tower of the other side in the width direction and a front side member of the one side in the width direction and extends between these top part and front side member.
A hose test system, comprising: a control system operatively coupled to a test system, said test system comprising: a hose test assembly configured to connect to a hose to be tested, and between an inlet high pressure valve and an outlet high pressure valve; an intensifier coupled to said inlet high pressure valve, capable of increasing the pressure within said hose test assembly when said inlet high pressure valve and said outlet high pressure valve are unactuated; wherein said control system is capable of controlling the operation of said intensifier of said test system, characterized in that said inlet high pressure valve and said outlet high pressure valve are seal-less and comprise: a body capable of housing a piston, wherein said piston is capable of being moved to actuated and unactuated positions, wherein said valves (160, 170) are capable of operating with oil at 700 bar, 150 degree Celsius, for a cycle of 1 second, for one million cycles without failing. a hose test assembly configured to connect to a hose to be tested, and between an inlet high pressure valve and an outlet high pressure valve; an intensifier coupled to said inlet high pressure valve, capable of increasing the pressure within said hose test assembly when said inlet high pressure valve and said outlet high pressure valve are unactuated; wherein said control system is capable of controlling the operation of said intensifier of said test system, a body capable of housing a piston, wherein said piston is capable of being moved to actuated and unactuated positions, wherein said valves (160, 170) are capable of operating with oil at 700 bar, 150 degree Celsius, for a cycle of 1 second, for one million cycles without failing.
A lens assembly for a vision system camera having variable focus comprising: a lens body having a variable lens assembly and a fixed optics assembly; and a controller that is located within the lens body, the controller being constructed and arranged to receive a target focal distance from the vision system camera, the controller generating, by translating the target focal distance, a target bobbin position of an actuator that controls curvature of the variable lens assembly and based upon an actual measured position of the actuator, correcting the measured position of the actuator to the target bobbin position; wherein the variable lens assembly comprises a membrane-based liquid lens assembly and further comprising a position sensor located to measure movement of the actuator, wherein the actuator is associated with movement of a membrane of the membrane-based liquid lens assembly, and wherein the actuator comprises a current-driven annular bobbin assembly with a magnetic coil that compresses the lens variable under different current settings and the controller is operatively connected with a current controller that provides current to the annular bobbin assembly; wherein the annular bobbin assembly includes a magnet and the position sensor comprises at least one Hall sensor. a lens body having a variable lens assembly and a fixed optics assembly; and a controller that is located within the lens body, the controller being constructed and arranged to receive a target focal distance from the vision system camera, the controller generating, by translating the target focal distance, a target bobbin position of an actuator that controls curvature of the variable lens assembly and based upon an actual measured position of the actuator, correcting the measured position of the actuator to the target bobbin position; wherein the variable lens assembly comprises a membrane-based liquid lens assembly and further comprising a position sensor located to measure movement of the actuator, wherein the actuator is associated with movement of a membrane of the membrane-based liquid lens assembly, and wherein the actuator comprises a current-driven annular bobbin assembly with a magnetic coil that compresses the lens variable under different current settings and the controller is operatively connected with a current controller that provides current to the annular bobbin assembly; wherein the annular bobbin assembly includes a magnet and the position sensor comprises at least one Hall sensor.