A compound of Formula, or a pharmaceutically acceptable salt thereof, having the structure: wherein: R 1 is selected from the group consisting of hydrogen, halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl, a substituted or unsubstituted C 3 -C 6 cycloalkyl, a substituted or unsubstituted C 1 -C 6 alkoxy, an unsubstituted mono-C 1 -C 6 alkylamine and an unsubstituted di-C 1 -C 6 alkylamine; each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl; or when m is 2 or 3, each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl, or two R 2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C 3 -C 6 cycloalkyl or a substituted or unsubstituted 3 to 6 membered heterocyclyl; R 3 is selected from the group consisting of X-R 3A, R 3A is a substituted or unsubstituted 5 to 10 membered heteroaryl; R 4 is selected from the group consisting of NO 2, S R 6, SO 2 R 6, halogen, cyano and an unsubstituted C 1 -C 6 haloalkyl; R 5 is-X 1 -(Alk 1) n -R 7; Alk 1 is selected from an unsubstituted C 1 -C 4 alkylene and a C 1 -C 4 alkylene substituted with 1, 2 or 3 substituents independently selected from fluoro, chloro, an unsubstituted C 1 -C 3 alkyl and an unsubstituted C 1 -C 3 haloalkyl; R 6 is selected from the group consisting of a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl; R 7 is selected from a substituted or unsubstituted C 3 -C 10 cycloalkyl and a substituted or unsubstituted 3 to 10 membered heterocyclyl; m is 0, 1, 2 or 3; n is selected from 0 and 1; X 1 is -NH-; and X is selected from the group consisting of -O-, -S- and -NH-; wherein cycloalkyl refers to a completely saturated mono- or multi-cyclic hydrocarbon ring system which, when composed of two or more rings, the rings may be joined together in a fused, bridged or spiro fashion; and wherein heterocyclyl refers to three- to 18-membered monocyclic, bicyclic or tricyclic ring systems wherein carbon atoms together with from 1 to 5 heteroatoms constitute said ring system which, when composed of two or more rings, the rings may be joined together in a fused, bridged or spiro fashion. R 1 is selected from the group consisting of hydrogen, halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl, a substituted or unsubstituted C 3 -C 6 cycloalkyl, a substituted or unsubstituted C 1 -C 6 alkoxy, an unsubstituted mono-C 1 -C 6 alkylamine and an unsubstituted di-C 1 -C 6 alkylamine; each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl; or when m is 2 or 3, each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl, or two R 2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C 3 -C 6 cycloalkyl or a substituted or unsubstituted 3 to 6 membered heterocyclyl; R 3 is selected from the group consisting of X-R 3A, R 3A is a substituted or unsubstituted 5 to 10 membered heteroaryl; R 4 is selected from the group consisting of NO 2, S R 6, SO 2 R 6, halogen, cyano and an unsubstituted C 1 -C 6 haloalkyl; R 5 is-X 1 -(Alk 1) n -R 7; Alk 1 is selected from an unsubstituted C 1 -C 4 alkylene and a C 1 -C 4 alkylene substituted with 1, 2 or 3 substituents independently selected from fluoro, chloro, an unsubstituted C 1 -C 3 alkyl and an unsubstituted C 1 -C 3 haloalkyl; R 6 is selected from the group consisting of a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl; R 7 is selected from a substituted or unsubstituted C 3 -C 10 cycloalkyl and a substituted or unsubstituted 3 to 10 membered heterocyclyl; m is 0, 1, 2 or 3; n is selected from 0 and 1; X 1 is -NH-; and X is selected from the group consisting of -O-, -S- and -NH-; wherein cycloalkyl refers to a completely saturated mono- or multi-cyclic hydrocarbon ring system which, when composed of two or more rings, the rings may be joined together in a fused, bridged or spiro fashion; and wherein heterocyclyl refers to three- to 18-membered monocyclic, bicyclic or tricyclic ring systems wherein carbon atoms together with from 1 to 5 heteroatoms constitute said ring system which, when composed of two or more rings, the rings may be joined together in a fused, bridged or spiro fashion.