mhurhangee/ep-ind-claims huggingface dataset:
An ULK1 inhibitor for use in the treatment of a disease or condition in a subject in need thereof, wherein the ULK1 inhibitor is co-administered with a therapeutically effective amount of an mTOR inhibitor; wherein: (a) the ULK1 inhibitor is a compound having the structure: wherein: R 1 is H; R 2 is selected from: R 4 is -NR 7 R 8, wherein R 7 is H and R 8 is selected from: N-alkylbenzamide, phenyl, cyclobutyl, alkoxyalkyl, and haloalkyl; R 5 is selected from: H, hydroxy, haloalkyl, halo, optionally substituted alkoxy, and optionally substituted aryl; and R 6 is H; or a pharmaceutically acceptable salt thereof; or (b) the ULK1 inhibitor is a compound having the structure: wherein: R 1 is H; R 2 is: R 4 is selected from: optionally substituted aryloxy, optionally substituted heteroaryloxy, and optionally substituted alkoxy; R 5 is selected from: H, hydroxyl, optionally substituted alkyl, halo, optionally substituted alkoxy, and optionally substituted aryl, wherein optionally substituted alkyl is CF 3 and halo is Br or Cl; and R 6 is H; or a pharmaceutically acceptable salt thereof. (a) the ULK1 inhibitor is a compound having the structure: wherein: R 1 is H; R 2 is selected from: R 4 is -NR 7 R 8, wherein R 7 is H and R 8 is selected from: N-alkylbenzamide, phenyl, cyclobutyl, alkoxyalkyl, and haloalkyl; R 5 is selected from: H, hydroxy, haloalkyl, halo, optionally substituted alkoxy, and optionally substituted aryl; and R 6 is H; or a pharmaceutically acceptable salt thereof; or R 1 is H; R 2 is selected from: R 4 is -NR 7 R 8, wherein R 7 is H and R 8 is selected from: N-alkylbenzamide, phenyl, cyclobutyl, alkoxyalkyl, and haloalkyl; R 5 is selected from: H, hydroxy, haloalkyl, halo, optionally substituted alkoxy, and optionally substituted aryl; and R 6 is H; (b) the ULK1 inhibitor is a compound having the structure: wherein: R 1 is H; R 2 is: R 4 is selected from: optionally substituted aryloxy, optionally substituted heteroaryloxy, and optionally substituted alkoxy; R 5 is selected from: H, hydroxyl, optionally substituted alkyl, halo, optionally substituted alkoxy, and optionally substituted aryl, wherein optionally substituted alkyl is CF 3 and halo is Br or Cl; and R 6 is H; or a pharmaceutically acceptable salt thereof. R 1 is H; R 2 is: R 4 is selected from: optionally substituted aryloxy, optionally substituted heteroaryloxy, and optionally substituted alkoxy; R 5 is selected from: H, hydroxyl, optionally substituted alkyl, halo, optionally substituted alkoxy, and optionally substituted aryl, wherein optionally substituted alkyl is CF 3 and halo is Br or Cl; and R 6 is H;
Mechanical device comprising a support and an elastic system, the elastic system comprising first and second elements (4, 5) to be guided relative to the support, a fixing part fixed to the support, a control part movable in translation with respect to the fixing part along a straight line, a first elastic member connecting the fixing part to the first element, a second elastic member connecting the fixing part to the second element, a third elastic member connecting the first element to the control part and a fourth elastic member connecting the second element to the control part, the assembly formed by the first elastic member, the first element and the third elastic member being symmetrical to the assembly formed by the second elastic member, the second element and the fourth elastic member with respect to said straight line in top plan view of the mechanical device, so that a translation of the control part along said straight line causes by deformation of the elastic members displacements of the first and second elements (4, 5) which are simultaneous and symmetrical with respect to said straight line in top plan view of the mechanical device.
A device for delivering ablative medical treatments to biological tissue to improve biomechanics of an eye comprising: a laser for generating a beam of laser radiation, operable for use in ablative medical treatments to a target eye tissue to create a matrix of pores that improves biomechanics of the eye; a controller in communication with the laser and operable to control dosimetry of the beam of laser radiation; a lens operable to focus the beam of laser radiation onto the target eye tissue; an eye tracking subsystem for tracking landmarks and movements of the eye; a depth control subsystem for controlling a depth of ablation on the target eye tissue; a scanning system communicatively coupled to the eye tracking subsystem and the depth control subsystem for scanning a focus spot over an area of the target eye tissue; an avoidance subsystem for identifying critical biological obstacles or locations of the eye; a power source operable to provide power to the device; and wherein the scanning system includes a biofeedback control loop configured to provide real-time feedback about the characteristics of the irradiated target eye tissue, including thickness, topography, focus, hydration during the ablative medical treatments; and wherein, the scanning system is configured to deliver the medical treatments comprising a complete circumferential treatment using a golden spiral pattern, the pattern having one of clockwise direction, counterclockwise direction, or combination thereof, the golden spiral being a logarithmic spiral that grows by a factor of φ = 1.618 for each quarter turn of the spiral. a laser for generating a beam of laser radiation, operable for use in ablative medical treatments to a target eye tissue to create a matrix of pores that improves biomechanics of the eye; a controller in communication with the laser and operable to control dosimetry of the beam of laser radiation; a lens operable to focus the beam of laser radiation onto the target eye tissue; an eye tracking subsystem for tracking landmarks and movements of the eye; a depth control subsystem for controlling a depth of ablation on the target eye tissue; a scanning system communicatively coupled to the eye tracking subsystem and the depth control subsystem for scanning a focus spot over an area of the target eye tissue; an avoidance subsystem for identifying critical biological obstacles or locations of the eye; a power source operable to provide power to the device; and wherein the scanning system includes a biofeedback control loop configured to provide real-time feedback about the characteristics of the irradiated target eye tissue, including thickness, topography, focus, hydration during the ablative medical treatments; and wherein, the scanning system is configured to deliver the medical treatments comprising a complete circumferential treatment using a golden spiral pattern, the pattern having one of clockwise direction, counterclockwise direction, or combination thereof, the golden spiral being a logarithmic spiral that grows by a factor of φ = 1.618 for each quarter turn of the spiral.
A secondary cell activation apparatus of a user equipment, UE, comprising: a configuration receiving unit, configured to receive configuration information of each secondary cell of all of one or more secondary cells sent by a base station of a primary cell of the user equipment, wherein the configuration information of each secondary cell comprises configuration information of an uplink control channel of said secondary cell; an information sending unit, configured to, in order to activate the secondary cell in which the user equipment is currently located, directly send a Media Access Control control element MAC CE on the uplink control channel of the secondary cell according to the configuration information that is of the uplink control channel of the secondary cell and which is received by the configuration receiving unit; and a data receiving unit, configured to receive downlink data sent by the base station of the primary cell by using a base station of the activated secondary cell; wherein the information sending unit is further configured to: determine a secondary cell with best signal quality as an activated secondary cell, and send the MAC CE on an uplink control channel of the determined activated secondary cell; or the information sending unit is further configured to: when a secondary cell list sent by the base station of the primary cell is received, determine a secondary cell that appears first in the secondary cell list as an activated secondary cell, and send the MAC CE on an uplink control channel of the determined activated secondary cell. a configuration receiving unit, configured to receive configuration information of each secondary cell of all of one or more secondary cells sent by a base station of a primary cell of the user equipment, wherein the configuration information of each secondary cell comprises configuration information of an uplink control channel of said secondary cell; an information sending unit, configured to, in order to activate the secondary cell in which the user equipment is currently located, directly send a Media Access Control control element MAC CE on the uplink control channel of the secondary cell according to the configuration information that is of the uplink control channel of the secondary cell and which is received by the configuration receiving unit; and a data receiving unit, configured to receive downlink data sent by the base station of the primary cell by using a base station of the activated secondary cell; wherein the information sending unit is further configured to: determine a secondary cell with best signal quality as an activated secondary cell, and send the MAC CE on an uplink control channel of the determined activated secondary cell; or the information sending unit is further configured to: when a secondary cell list sent by the base station of the primary cell is received, determine a secondary cell that appears first in the secondary cell list as an activated secondary cell, and send the MAC CE on an uplink control channel of the determined activated secondary cell.
A memory cell, comprising: a static random-access memory, SRAM, bit cell; a first resistive memory element having a first terminal connected to a first storage node of the SRAM bit cell and a second terminal connected to a first intermediate node; and a second resistive memory element having a first terminal connected to a second storage node of the SRAM bit cell and a second terminal connected to a second intermediate node; wherein the first storage node is further connected to a first access transistor and the second storage node is further connected to a second access transistor, said first and second access transistors (PG1, PG2) being controllable by a SRAM bit cell word line, wherein the first access transistor is coupled between the first storage node and a first bit line and the second access transistor is coupled between the second storage node and a second bit line, wherein each one of the first intermediate node and the second intermediate node is configured to be supplied with a first supply voltage (V DD) via a first transistor (131, 141) and a second supply voltage (Vss) via a second transistor (132, 142); and wherein the first transistor (131, 141) and the second transistor (132, 142) are complementary transistors; the first transistor is controllable by a first word line and the second transistor (132, 142) is controllable by a second word line, and wherein the first word line, the second word line and the SRAM bit cell word line are configured to be supplied with the same or different voltages. a static random-access memory, SRAM, bit cell; a first resistive memory element having a first terminal connected to a first storage node of the SRAM bit cell and a second terminal connected to a first intermediate node; and a second resistive memory element having a first terminal connected to a second storage node of the SRAM bit cell and a second terminal connected to a second intermediate node; wherein the first storage node is further connected to a first access transistor and the second storage node is further connected to a second access transistor, said first and second access transistors (PG1, PG2) being controllable by a SRAM bit cell word line, wherein the first access transistor is coupled between the first storage node and a first bit line and the second access transistor is coupled between the second storage node and a second bit line, wherein each one of the first intermediate node and the second intermediate node is configured to be supplied with a first supply voltage (V DD) via a first transistor (131, 141) and a second supply voltage (Vss) via a second transistor (132, 142); and wherein the first transistor (131, 141) and the second transistor (132, 142) are complementary transistors; the first transistor is controllable by a first word line and the second transistor (132, 142) is controllable by a second word line, and wherein the first word line, the second word line and the SRAM bit cell word line are configured to be supplied with the same or different voltages.
An electrospinning device comprising: - a container for holding a liquid comprising a polymer melt or a polymer solution; - a nozzle arranged to outlet a stream of the liquid from the container; - a collector for collecting electro spun material coming from the nozzle during an electrospinning process so as to form a fibrous structure on a surface of the collector; - a voltage supply system arranged to create a voltage difference between the nozzle and the collector, - an optical measurement system (8,12;108) arranged to measure a baseline distance between the surface of the collector and the optical measurement system at at least one predefined location, and to repeatedly measure a momentary distance between a momentary top layer of the fibrous structure and the optical measurement system at the at least one predefined location during the electrospinning process - a processor arranged to receive the measured baseline distance and the momentary distance from the optical measurement system and to calculate a momentary thickness of the fibrous structure for the at least one location. - a container for holding a liquid comprising a polymer melt or a polymer solution; - a nozzle arranged to outlet a stream of the liquid from the container; - a collector for collecting electro spun material coming from the nozzle during an electrospinning process so as to form a fibrous structure on a surface of the collector; - a voltage supply system arranged to create a voltage difference between the nozzle and the collector, - an optical measurement system (8,12;108) arranged to measure a baseline distance between the surface of the collector and the optical measurement system at at least one predefined location, and to repeatedly measure a momentary distance between a momentary top layer of the fibrous structure and the optical measurement system at the at least one predefined location during the electrospinning process - a processor arranged to receive the measured baseline distance and the momentary distance from the optical measurement system and to calculate a momentary thickness of the fibrous structure for the at least one location.
An dispersant composition comprising: a) at least one oligomeric acid A, which has - at least one acidic group selected from COOH and PO 3 H 2 and - at least one polyoxyalkylene-ether radical of the formula R-(O-A) x O-G- where A is an C 2 -C 4 -alkan-1,2-diyl radical; X is an integer having a number average value in the range from 2 to 20; R is hydrocarbon radical having from 1 to 30 carbon atoms; G is a chemical bond or a carbonyl group; and b) at least one polyamine B, which is selected from the group consisting of polyvinylamines, poly-C 2 -C 3 -alkyleneimines, modified poly-C 2 -C 3 -alkyleneimines, melamines, modified melamines, poly-(C 2 -C 4 -alkyleneether) amines, polyetheramine polyols, and modified polyetheramine polyols. a) at least one oligomeric acid A, which has - at least one acidic group selected from COOH and PO 3 H 2 and - at least one polyoxyalkylene-ether radical of the formula R-(O-A) x O-G- where A is an C 2 -C 4 -alkan-1,2-diyl radical; X is an integer having a number average value in the range from 2 to 20; R is hydrocarbon radical having from 1 to 30 carbon atoms; G is a chemical bond or a carbonyl group; and - at least one acidic group selected from COOH and PO 3 H 2 and - at least one polyoxyalkylene-ether radical of the formula R-(O-A) x O-G- where A is an C 2 -C 4 -alkan-1,2-diyl radical; X is an integer having a number average value in the range from 2 to 20; R is hydrocarbon radical having from 1 to 30 carbon atoms; G is a chemical bond or a carbonyl group; A is an C 2 -C 4 -alkan-1,2-diyl radical; X is an integer having a number average value in the range from 2 to 20; R is hydrocarbon radical having from 1 to 30 carbon atoms; G is a chemical bond or a carbonyl group; b) at least one polyamine B, which is selected from the group consisting of polyvinylamines, poly-C 2 -C 3 -alkyleneimines, modified poly-C 2 -C 3 -alkyleneimines, melamines, modified melamines, poly-(C 2 -C 4 -alkyleneether) amines, polyetheramine polyols, and modified polyetheramine polyols.
A communication device for providing access to a service via an access point in a cellular communication system, the communication device comprising: an application for accessing said service via said access point; means for receiving, from the application, a service identifier for said service; means for obtaining an identifier of an access point via which said service can be accessed by said application by mapping said service identifier to said identifier of an access point; means for associating, with said application, said identifier of an access point via which said service can be accessed by said application obtained by said obtaining means; and means for directing communication traffic from said application to the access point identified by said identifier of an access point associated with said application by said associating means, wherein said obtaining means is further operable to obtain for the each obtained identifier of an access point, information identifying a restriction associated with use of the access point represented by that obtained identifier, the information identifying a restriction indicates that said use of the access point represented by the obtained identifier is restricted to certain applications, and the information identifying a restriction comprises a key that must be provided by the application in order to be able to use the access point represented by that obtained identifier. an application for accessing said service via said access point; means for receiving, from the application, a service identifier for said service; means for obtaining an identifier of an access point via which said service can be accessed by said application by mapping said service identifier to said identifier of an access point; means for associating, with said application, said identifier of an access point via which said service can be accessed by said application obtained by said obtaining means; and means for directing communication traffic from said application to the access point identified by said identifier of an access point associated with said application by said associating means, wherein said obtaining means is further operable to obtain for the each obtained identifier of an access point, information identifying a restriction associated with use of the access point represented by that obtained identifier, the information identifying a restriction indicates that said use of the access point represented by the obtained identifier is restricted to certain applications, and the information identifying a restriction comprises a key that must be provided by the application in order to be able to use the access point represented by that obtained identifier.
Method for distributed multi-hop packet forwarding based on geographic coordinates for vehicular communications between nodes, each node having its own geographical coordinates and the geographical coordinates of the destination node of one said vehicular communication being known, said method comprising each node obtaining its one-hop neighbor nodes' coordinates from periodically broadcast beacons from said neighbor nodes and said method being characterized by comprising the steps for each node, at each hop, upon receiving a packet: - based on the current node's position and the packet header information, verifying if the current node (fig. 2 - d) is closer to the destination (fig. 2 - destination) than the previous hop (fig. 2 - source); if not, dropping the packet; - ranking the utility of the current node (fig. 2 - d) as a forwarder against the utility of the potential forwarder nodes (fig. 2 - a, b, c, d) which are the said one-hop neighbor nodes that are closer to the destination than the previous hop; - if the current node (fig. 2 - d) is one of a predetermined number of best utility ranked forwarder nodes (fig. 2 - c, d), then considering the current node as being in the forwarding zone; if not, dropping the packet; - if the current node (fig. 2 - d) is in the forwarding zone, waiting a period of time inversely proportional to the current node utility rank before forwarding the packet; - if, while waiting, the current node (fig. 2 - d) overhears another node (fig. 2 - c) forwarding the same packet, cancelling the forwarding of the packet; wherein the packet header comprises three node addresses: original packet source (fig. 2 - source), packet destination (fig. 2 - destination), and packet previous hop (fig. 2 - source), wherein each address includes both the respective node identifier and geographic coordinates, and wherein said nodes are vehicle nodes or a mix of vehicle nodes and fixed nodes. - based on the current node's position and the packet header information, verifying if the current node (fig. 2 - d) is closer to the destination (fig. 2 - destination) than the previous hop (fig. 2 - source); if not, dropping the packet; - ranking the utility of the current node (fig. 2 - d) as a forwarder against the utility of the potential forwarder nodes (fig. 2 - a, b, c, d) which are the said one-hop neighbor nodes that are closer to the destination than the previous hop; - if the current node (fig. 2 - d) is one of a predetermined number of best utility ranked forwarder nodes (fig. 2 - c, d), then considering the current node as being in the forwarding zone; if not, dropping the packet; - if the current node (fig. 2 - d) is in the forwarding zone, waiting a period of time inversely proportional to the current node utility rank before forwarding the packet; - if, while waiting, the current node (fig. 2 - d) overhears another node (fig. 2 - c) forwarding the same packet, cancelling the forwarding of the packet;