mhurhangee/ep-ind-claims huggingface dataset:
A composition comprising a combination of a TNFα immunoconjugate and an IL2 immunoconjugate for use in a method of treating a skin tumour in a patient by injecting a single dose of the composition, wherein the TNFα immunoconjugate comprises TNFα linked to an antibody molecule that binds to extra domain ED-B of fibronectin splice isoform B-FN, and the IL2 immunoconjugate comprises IL2 linked to an antibody molecule that binds to extra domain ED-B of fibronectin splice isoform B-FN, wherein the method comprises intratumoural injection of the composition.
A method of detecting asymmetric icing on a wind turbine, the method comprising: providing a lateral tower acceleration monitoring system; determining from the lateral tower acceleration monitoring system whether a lateral tower acceleration is above an acceleration limit; receiving a rotor position; determining whether a rotor-mass imbalance condition exists (220,230) by determining whether a maximum tower acceleration periodically occurs near the rotor position where a previous maximum tower acceleration occurred; and determining whether the lateral tower acceleration coincides with icing on a rotor of the wind turbine. providing a lateral tower acceleration monitoring system; determining from the lateral tower acceleration monitoring system whether a lateral tower acceleration is above an acceleration limit; receiving a rotor position; determining whether a rotor-mass imbalance condition exists (220,230) by determining whether a maximum tower acceleration periodically occurs near the rotor position where a previous maximum tower acceleration occurred; and determining whether the lateral tower acceleration coincides with icing on a rotor of the wind turbine.
System for containing a biopharmaceutical fluid comprising: - a protecting body for a flexible pouch specially designed to contain a biopharmaceutical fluid, wherein the protecting body comprises two plates (12A, 12B) which respectively form a lower surface and an upper surface and which are fixed to each other, the two plates being substantially planar and being able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and comprises, on a peripheral side, at least one opening able to receive at least one port of the flexible pouch, and - a protecting package comprising two frames (112A, 112B) that respectively form a lower frame and an upper frame of the system and which have a peripheral area, respectively to a main plane of the frames, each of the two frames (112A, 112B) having an opening on a central area, wherein the two frames (112A, 112B) are fixed to each other such that they are able to respectively surround the two plates (12A, 12B) which sandwich the flexible pouch. - a protecting body for a flexible pouch specially designed to contain a biopharmaceutical fluid, wherein the protecting body comprises two plates (12A, 12B) which respectively form a lower surface and an upper surface and which are fixed to each other, the two plates being substantially planar and being able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and comprises, on a peripheral side, at least one opening able to receive at least one port of the flexible pouch, and - a protecting package comprising two frames (112A, 112B) that respectively form a lower frame and an upper frame of the system and which have a peripheral area, respectively to a main plane of the frames, each of the two frames (112A, 112B) having an opening on a central area,
Method for treating the surface of a panel in order to reduce its conductivity, said surface being located in an area, called a cold area, said area being located near an area in which an electric arc may occur in an electric protection apparatus, said cold area forming an area of recondensation of the switching residues, characterized in that it consists in forming micro-texturing on this surface so as to promote inhomogeneity of the recondensation of the switching residues, as a result of the growth of the deposits of these residues on the surface in such a way as to create islands of residues and thus limit the conductivity of the resulting deposit.
A device for measuring a level of a fluid in a container, based on an acoustic measurement principle, comprising - an acoustically active component for transmitting a sound pulse into the fluid and for receiving an echo of the sound pulse, - an electronic circuit arrangement for controlling the transmission of the sound pulse by providing a control signal to the acoustically active component and for processing a reception signal provided by the acoustically active component due to the receipt of the echo, wherein the acoustically active component and the electronic circuit arrangement are combined in a packaged module provided with a plurality of electrical contact elements protruding from an enclosure of the packaged module, wherein the device further comprises a housing provided with electrical conductors embedded in or attached to the housing, wherein the electrical contact elements of the packaged module are electrically connected to the electrical conductors of the housing, characterized in that the acoustically active component is acoustically coupled to the housing so that the sound pulse is only transmitted through the housing to the fluid beyond the housing and the echo is received through the housing. - an acoustically active component for transmitting a sound pulse into the fluid and for receiving an echo of the sound pulse, - an electronic circuit arrangement for controlling the transmission of the sound pulse by providing a control signal to the acoustically active component and for processing a reception signal provided by the acoustically active component due to the receipt of the echo, wherein the acoustically active component and the electronic circuit arrangement are combined in a packaged module provided with a plurality of electrical contact elements protruding from an enclosure of the packaged module,
Method for ejecting a piece good from a load-receiving means, comprising the following method steps: - implementing a transport travel of the piece good on the load-receiving means by moving the load-receiving means; - ejecting the piece good by means of an ejection device which is arranged or included on the load-receiving means and which accelerates the piece good during the transport travel in an ejection direction (a) with a vectorial component counter to the instantaneous direction of travel (v) of the load-receiving means; wherein the piece good is ejected from the load-receiving means into a further load-receiving means which, at the time of ejection, is situated below the load-receiving means, characterized in that the load-receiving means is a driverless transport vehicle. - implementing a transport travel of the piece good on the load-receiving means by moving the load-receiving means; - ejecting the piece good by means of an ejection device which is arranged or included on the load-receiving means and which accelerates the piece good during the transport travel in an ejection direction (a) with a vectorial component counter to the instantaneous direction of travel (v) of the load-receiving means; wherein the piece good is ejected from the load-receiving means into a further load-receiving means which, at the time of ejection, is situated below the load-receiving means, characterized in that the load-receiving means is a driverless transport vehicle.
Turbine vane for a rotary turbomachine, the turbine vane comprising a turbine blade which is delimited by a concave pressure-side wall and a convex suction-side wall which are connected in the region of a vane leading edge assigned to the turbine blade, and enclose a cavity which extends in the longitudinal extent of the vane leading edge and is delimited on the inner wall by the pressure-side wall and the suction-side wall in the region of the vane leading edge and by an intermediate wall which extends in the longitudinal direction to the vane leading edge and connects the suction-side wall and the pressure-side wall on their inner walls, wherein the turbine vane has a rounding or hollow groove at the transition from the intermediate wall to the suction-side wall and/or pressure-side wall, characterised in that the intermediate wall has a perforation at least in portions in a connecting region to the suction-side wall and/or pressure-side wall in order to increase the elasticity of the intermediate wall in the connecting region, wherein the connecting region is restricted to a region from the suction-side wall and/or pressure-side wall which corresponds to twice the radius of the rounding or hollow groove.
A system for generating hydrogen by dissociation of water, comprising: a hydrogen generation chamber for generating hydrogen from water, said water containing electrolytes; wherein said hydrogen generation chamber comprises: (a) a fluid-tight inner chamber including a fluid-tight wall; and (b) a fluid-tight outer chamber at least partially surrounding said inner chamber, said outer chamber adapted to contain a liquid comprising the water; said outer chamber comprising (i) a fluid inlet adapted to allow ingress of said liquid comprising water and (ii) a fluid outlet adapted to allow egress of gas; an energy source for providing energy to drive dissociation of the water; and a control unit for controlling said energy source and liquid and gas flow; wherein said energy source is a source of radiofrequency electromagnetic energy, and wherein said source of RF energy comprises an antenna located within the inner chamber; the wall of said inner chamber adapted to allow passage therethrough of said RF energy, said inner chamber being adapted to prevent contact between said antenna and said water in an outer chamber. a hydrogen generation chamber for generating hydrogen from water, said water containing electrolytes; wherein said hydrogen generation chamber comprises: (a) a fluid-tight inner chamber including a fluid-tight wall; and (b) a fluid-tight outer chamber at least partially surrounding said inner chamber, said outer chamber adapted to contain a liquid comprising the water; said outer chamber comprising (i) a fluid inlet adapted to allow ingress of said liquid comprising water and (ii) a fluid outlet adapted to allow egress of gas; (a) a fluid-tight inner chamber including a fluid-tight wall; and (b) a fluid-tight outer chamber at least partially surrounding said inner chamber, said outer chamber adapted to contain a liquid comprising the water; said outer chamber comprising (i) a fluid inlet adapted to allow ingress of said liquid comprising water and (ii) a fluid outlet adapted to allow egress of gas; an energy source for providing energy to drive dissociation of the water; and a control unit for controlling said energy source and liquid and gas flow; wherein said energy source is a source of radiofrequency electromagnetic energy, and wherein said source of RF energy comprises an antenna located within the inner chamber; the wall of said inner chamber adapted to allow passage therethrough of said RF energy, said inner chamber being adapted to prevent contact between said antenna and said water in an outer chamber.
A method of making a genetically engineered cell, the method comprising a) providing a cell, wherein the cell comprises a first nucleotide sequence, wherein the first nucleotide sequence comprises a coding strand, the coding strand comprising one or more regulatory elements and a FOXP3 gene or portion thereof; and b) providing a second nucleotide sequence encoding a nuclease or providing a protein nuclease, and c) introducing the second nucleotide sequence or protein nuclease into the cell for a gene editing process, wherein the gene editing process is a gene knock-in process for insertion of a heterologous promoter into the first nucleotide sequence, wherein the heterologous promoter is upstream from the first coding exon of the FOXP3 gene and downstream from the one or more regulatory elements on the coding strand; and/or the genetic modification results in a synthetic first coding exon of the FOXP3 gene that is created through completion of the gene editing process, wherein the heterologous promoter is upstream from the synthetic first coding exon and downstream from the one or more regulatory elements on the coding strand. a) providing a cell, wherein the cell comprises a first nucleotide sequence, wherein the first nucleotide sequence comprises a coding strand, the coding strand comprising one or more regulatory elements and a FOXP3 gene or portion thereof; and b) providing a second nucleotide sequence encoding a nuclease or providing a protein nuclease, and c) introducing the second nucleotide sequence or protein nuclease into the cell for a gene editing process, wherein the gene editing process is a gene knock-in process for insertion of a heterologous promoter into the first nucleotide sequence, wherein the heterologous promoter is upstream from the first coding exon of the FOXP3 gene and downstream from the one or more regulatory elements on the coding strand; and/or the genetic modification results in a synthetic first coding exon of the FOXP3 gene that is created through completion of the gene editing process, wherein the heterologous promoter is upstream from the synthetic first coding exon and downstream from the one or more regulatory elements on the coding strand.
A microstructure apparatus, comprising: an approximately planar substrate having a first surface and a second surface opposed thereto; and a microstructure array comprising a plurality of microstructures contacting the first surface of the substrate and fixedly attached thereto, the microstructures being formed of a polymer matrix comprising: (a) at least one water-insoluble, biodegradeable polymer; (b) 20% of a hydrophilic component, wherein the hydrophilic component is PEG-PLGA; and (c) at least one therapeutic agent; wherein release of the therapeutic agent from the polymer matrix is sustained for a period of at least 1-144 hours; wherein the polymer matrix is composed to release the therapeutic agent from the polymer matrix at an initial release rate of about 0.05-10% / minute; wherein the microstructures comprise the therapeutic agent dispersed in the polymer matrix; and wherein the sustained release and the initial release are measured in accordance with the method defined in the description. an approximately planar substrate having a first surface and a second surface opposed thereto; and a microstructure array comprising a plurality of microstructures contacting the first surface of the substrate and fixedly attached thereto, the microstructures being formed of a polymer matrix comprising: (a) at least one water-insoluble, biodegradeable polymer; (b) 20% of a hydrophilic component, wherein the hydrophilic component is PEG-PLGA; and (c) at least one therapeutic agent; (a) at least one water-insoluble, biodegradeable polymer; (b) 20% of a hydrophilic component, wherein the hydrophilic component is PEG-PLGA; and (c) at least one therapeutic agent; wherein release of the therapeutic agent from the polymer matrix is sustained for a period of at least 1-144 hours; wherein the polymer matrix is composed to release the therapeutic agent from the polymer matrix at an initial release rate of about 0.05-10% / minute; wherein the microstructures comprise the therapeutic agent dispersed in the polymer matrix; and wherein the sustained release and the initial release are measured in accordance with the method defined in the description.
An automatic analyzer for conducting component analysis by performing measurement on a reaction liquid that was caused to react chemically in a reaction vessel, the analyzer comprising: a probe (111b, 120) for suctioning a sample or a reagent and discharging the sample or the reagent into a reaction vessel; a cleaning bath (108, 113) in which to clean the probe; a cleaning water supply unit for supplying cleaning water to the cleaning bath to clean the probe; a compressed air supply unit for supplying compressed air to the cleaning bath; and a controller for controlling the probe, the cleaning water supply unit, and the compressed air supply unit, wherein the cleaning bath comprises a cleaning water outlet for discharging into the cleaning bath the cleaning water supplied from the cleaning water supply unit, and a compressed air outlet for discharging the compressed air supplied from the compressed air supply unit toward the probe inserted in the cleaning bath, characterized by the automatic analyzer being configured such that the compressed air outlet is disposed on the trajectory of the cleaning water having been discharged from the cleaning water outlet. a probe (111b, 120) for suctioning a sample or a reagent and discharging the sample or the reagent into a reaction vessel; a cleaning bath (108, 113) in which to clean the probe; a cleaning water supply unit for supplying cleaning water to the cleaning bath to clean the probe; a compressed air supply unit for supplying compressed air to the cleaning bath; and a controller for controlling the probe, the cleaning water supply unit, and the compressed air supply unit, wherein the cleaning bath comprises a cleaning water outlet for discharging into the cleaning bath the cleaning water supplied from the cleaning water supply unit, and a compressed air outlet for discharging the compressed air supplied from the compressed air supply unit toward the probe inserted in the cleaning bath, characterized by the automatic analyzer being configured such that the compressed air outlet is disposed on the trajectory of the cleaning water having been discharged from the cleaning water outlet. a cleaning water outlet for discharging into the cleaning bath the cleaning water supplied from the cleaning water supply unit, and a compressed air outlet for discharging the compressed air supplied from the compressed air supply unit toward the probe inserted in the cleaning bath, characterized by the automatic analyzer being configured such that the compressed air outlet is disposed on the trajectory of the cleaning water having been discharged from the cleaning water outlet.
A composition comprising baclofen, sorbitol and naltrexone, or salts, enantiomers or racemates thereof, for use in promoting or improving nerve regeneration in a subject suffering from a traumatic neuropathy or a mechanical neuronal insult.
A sensor comprising: a magnetic field signal generating circuit comprising at least one sensing element (24a, 24b), for generating a magnetic field signal indicative of features of a rotational ferromagnetic object as the features pass in front of the at least one sensing element; a threshold detector, responsive to the magnetic field signal, for generating a threshold detector output signal having transitions associated with cycles of the magnetic field signal; a peak detector, responsive to the magnetic field signal, for generating a peak detector output signal having transitions associated with the cycles of the magnetic field signal; and a circuit, coupled to the threshold detector and peak detector, and arranged to detect the transitions of the threshold detector output signal and peak detector output signal, and to use the detected transitions to detect an error if a sequence in which the transitions occur deviates from an expected sequence. a magnetic field signal generating circuit comprising at least one sensing element (24a, 24b), for generating a magnetic field signal indicative of features of a rotational ferromagnetic object as the features pass in front of the at least one sensing element; a threshold detector, responsive to the magnetic field signal, for generating a threshold detector output signal having transitions associated with cycles of the magnetic field signal; a peak detector, responsive to the magnetic field signal, for generating a peak detector output signal having transitions associated with the cycles of the magnetic field signal; and a circuit, coupled to the threshold detector and peak detector, and arranged to detect the transitions of the threshold detector output signal and peak detector output signal, and to use the detected transitions to detect an error if a sequence in which the transitions occur deviates from an expected sequence.
A shutdown controller for a wind turbine, the controller comprising at least two sensors being adapted to provide sensor data significant for different mechanical states (x 1, x 8) in the wind turbine, the controller being adapted to provide an estimated state ( X̂) of the wind turbine based on the sensor data from the at least two sensors, wherein the controller is adapted to compare the state of the wind turbine with a predefined detection limit (X A), and to provide a shutdown signal if the estimated state is outside the detection limit, said controller being further adapted to select between different control schemes, each specifying at least one of the detection limit and a shutdown pitching strategy; characterized in that said controller is adapted to determine a fatigue load history and to select the control scheme there from.
A connecting terminal for connecting at least two electrical conductors to one another, wherein the connecting terminal has at least two separate housing parts (1, 2), which are connected mechanically to one another and, on opposite housing sides, each have a conductor insertion opening (10, 20) for at least one electrical conductor which is to be connected, wherein there is a first spring-force clamping connection (31, 120) for making electrical contact with a first electrical conductor in a first housing part of the at least two separate housing parts (1, 2), and there is a second spring-force clamping connection (32, 220) for making electrical contact with the second electrical conductor in the second housing part of the at least two separate housing parts (1, 2), wherein the first housing part is coupled mechanically to the second housing part via coupling means (16, 17, 18, 26, 27, 28) formed on the respective housing part (1, 2), characterized in that the first housing part is additionally coupled mechanically to the second housing part via a connecting part arranged in the region of transition from the first to the second housing part and formed as a separate component, wherein the connecting part is situated in the interior of the housing parts (1, 2), in the region of transition from one housing part to the other housing part.