A compound of Formula: or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate thereof, wherein: ring A is selected from aryl and a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), S p, and O, wherein said aryl and heterocycle are optionally substituted with R 1; ring B is a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, S p, and O, wherein said heterocycle is optionally substituted with R 10; ring C is a 4- to 5-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NR 9, S p, and O, wherein said heterocycle is optionally substituted with R 2; X 1 is selected from C 1-4 alkylene, and C 2-4 alkenylene; optionally one or more of the carbon atoms of said alkylene and alkenylene may be replaced by O, S p, NH, and N(C 1-4 alkyl); R 1 is, independently at each occurrence, selected from H, halogen, NO 2, C 1-6 alkyl, OH, OMe, and CN; R 2 is selected from H, =O, OH, NH 2, CF 3, halogen, and C 1-4 alkyl optionally substituted with OH; R 3 is selected from H and C 1-4 alkyl; alternatively, R 2 and R 3, together with the atoms to which they are directly or indirectly attached, form a ring wherein said ring is optionally substituted with =O; R 4 is selected from H, C 1-4 alkyl, hydroxyl, and C 3-6 cycloalkyl; R 5 is selected from H and C 1-4 alkyl; R 6 is selected from H, halogen, C OH, and C O(C 1-4 alkyl); R 7 is selected from H, C 1-4 alkyl, and CF 3; alternatively, R 6 and R 7 together are =O; R 8 is, independently at each occurrence, selected from H, halogen, NHC O-C 1-4 alkyl, CN, OH, O-C 1-4 alkyl; CF 3, CO 2 H, CO 2 (C 1-4 alkyl), -CH 2 CO 2 H, -(CH 2) 2 CO 2 H, -CH 2 CO 2 (C 1-4 alkyl), -(CH 2) 2 CO 2 (C 1-4 alkyl), NH 2, -CH 2 NH 2, -NHCO(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-3 0(C 1-4 alkyl), NHCO 2 CH 2 CH(C 1-4 alkyl)O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 OH, -NHCO 2 CH 2 CO 2 H, -CH 2 NHCO 2 (C 1-4 alkyl), -NHC NH(C 1-4 alkyl), -NHC N(C 1-4 alkyl) 2, NHC NH(C 1-4 alkyl)N[5- to 6-membered heterocycle)], -NHSO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, and -CH 2 CONH 2; R 9 is selected from H and C 1-4 alkyl; R 10 is, independently at each occurrence, selected from H, halogen, CN, =O, OH, NH 2, C 3-6 cycloalkyl, C 1-4 alkoxy, CF 3, CH 2 OH, CO 2 H, CO 2 (C 1-4 alkyl), and CONH; and p is, independently at each occurrence, selected from 0, 1, and 2; provided the following compounds are excluded and ring A is selected from aryl and a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4 alkyl), S p, and O, wherein said aryl and heterocycle are optionally substituted with R 1; ring B is a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NH, S p, and O, wherein said heterocycle is optionally substituted with R 10; ring C is a 4- to 5-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NR 9, S p, and O, wherein said heterocycle is optionally substituted with R 2; X 1 is selected from C 1-4 alkylene, and C 2-4 alkenylene; optionally one or more of the carbon atoms of said alkylene and alkenylene may be replaced by O, S p, NH, and N(C 1-4 alkyl); R 1 is, independently at each occurrence, selected from H, halogen, NO 2, C 1-6 alkyl, OH, OMe, and CN; R 2 is selected from H, =O, OH, NH 2, CF 3, halogen, and C 1-4 alkyl optionally substituted with OH; R 3 is selected from H and C 1-4 alkyl; alternatively, R 2 and R 3, together with the atoms to which they are directly or indirectly attached, form a ring wherein said ring is optionally substituted with =O; R 4 is selected from H, C 1-4 alkyl, hydroxyl, and C 3-6 cycloalkyl; R 5 is selected from H and C 1-4 alkyl; R 6 is selected from H, halogen, C OH, and C O(C 1-4 alkyl); R 7 is selected from H, C 1-4 alkyl, and CF 3; alternatively, R 6 and R 7 together are =O; R 8 is, independently at each occurrence, selected from H, halogen, NHC O-C 1-4 alkyl, CN, OH, O-C 1-4 alkyl; CF 3, CO 2 H, CO 2 (C 1-4 alkyl), -CH 2 CO 2 H, -(CH 2) 2 CO 2 H, -CH 2 CO 2 (C 1-4 alkyl), -(CH 2) 2 CO 2 (C 1-4 alkyl), NH 2, -CH 2 NH 2, -NHCO(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-3 0(C 1-4 alkyl), NHCO 2 CH 2 CH(C 1-4 alkyl)O(C 1-4 alkyl), -NHCO 2 (CH 2) 1-2 OH, -NHCO 2 CH 2 CO 2 H, -CH 2 NHCO 2 (C 1-4 alkyl), -NHC NH(C 1-4 alkyl), -NHC N(C 1-4 alkyl) 2, NHC NH(C 1-4 alkyl)N[5- to 6-membered heterocycle)], -NHSO 2 (C 1-4 alkyl), -CONH 2, -CONH(C 1-4 alkyl), -CON(C 1-4 alkyl) 2, and -CH 2 CONH 2; R 9 is selected from H and C 1-4 alkyl; R 10 is, independently at each occurrence, selected from H, halogen, CN, =O, OH, NH 2, C 3-6 cycloalkyl, C 1-4 alkoxy, CF 3, CH 2 OH, CO 2 H, CO 2 (C 1-4 alkyl), and CONH; and p is, independently at each occurrence, selected from 0, 1, and 2;