A compound of Formula I-C: or a pharmaceutically acceptable salt thereof, wherein: X is CR 5 or N; Y is CR 6 or N, wherein at least one of X and Y is N; Z is -O-, -S-, -C(HR 7)-, -N(R 8)- or absent; R 1 is optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 heteroalkyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 3 -C 10 heterocycloalkyl, optionally substituted C 6 -C 10 aryl or optionally substituted C 5 -C 18 heteroaryl; R 4 is nitro, halo, cyano, optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 5 -C 18 heteroaryl, carboxyl, sulfinyl, sulfonamidyl, sulfonyl, sulfoximinyl or C 1 -C 4 fluoroalkylsulfonyl; R 5, R 6, R 7 and R 8 are independently hydrogen, halo, hydroxy, cyano, optionally substituted C 1 -C 10 alkyl or optionally substituted C 1 -C 4 alkoxy; R 11 is hydroxy or optionally substituted amino; R 12 is hydrogen, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; or R 11 and R 12 in combination form oxo or oxime; each of R 13 is independently selected from the group consisting of hydrogen, fluoro, chloro, hydroxy, optionally substituted C 1 -C 10 alkyl and optionally substituted C 1 -C 10 heteroalkyl; or two R 13 s and the carbon atom(s) to which they are attached form an optionally substituted 3- to 8-membered cycloalkyl or optionally substituted C 3 -C 10 heterocycloalkyl moiety; and n is 0, 1, 2, 3 or 4; wherein the optional substituents where present on each optionally substituted group are independently selected from C 1 -C 4 alkyl, C 1 -C 4 heteroalkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocycloalkyl, C 6 -C 10 aryl, C 5 -C 18 heteroaryl, hydroxy, C 1 -C 4 alkoxy, cyano, halo, -C(=O)OR a, C 1 -C 4 fluoroalkyl and -N(R a) 2, wherein each R a is independently hydrogen, C 1 -C 10 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 10 heteroalkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocycloalkyl, C 3 -C 10 heterocycloalkylC 1 -C 4 alkyl, C 6 -C 10 aryl, C 6 -C 10 arylC 1 -C 4 alkyl, C 5 -C 18 heteroaryl, or C 5 -C 18 heteroarylC 1 -C 4 alkyl. X is CR 5 or N; Y is CR 6 or N, wherein at least one of X and Y is N; Z is -O-, -S-, -C(HR 7)-, -N(R 8)- or absent; R 1 is optionally substituted C 1 -C 10 alkyl, optionally substituted C 1 -C 10 heteroalkyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 3 -C 10 heterocycloalkyl, optionally substituted C 6 -C 10 aryl or optionally substituted C 5 -C 18 heteroaryl; R 4 is nitro, halo, cyano, optionally substituted C 1 -C 10 alkyl, optionally substituted C 3 -C 10 cycloalkyl, optionally substituted C 5 -C 18 heteroaryl, carboxyl, sulfinyl, sulfonamidyl, sulfonyl, sulfoximinyl or C 1 -C 4 fluoroalkylsulfonyl; R 5, R 6, R 7 and R 8 are independently hydrogen, halo, hydroxy, cyano, optionally substituted C 1 -C 10 alkyl or optionally substituted C 1 -C 4 alkoxy; R 11 is hydroxy or optionally substituted amino; R 12 is hydrogen, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl or optionally substituted C 2 -C 10 alkynyl; or R 11 and R 12 in combination form oxo or oxime; each of R 13 is independently selected from the group consisting of hydrogen, fluoro, chloro, hydroxy, optionally substituted C 1 -C 10 alkyl and optionally substituted C 1 -C 10 heteroalkyl; or two R 13 s and the carbon atom(s) to which they are attached form an optionally substituted 3- to 8-membered cycloalkyl or optionally substituted C 3 -C 10 heterocycloalkyl moiety; and n is 0, 1, 2, 3 or 4; wherein the optional substituents where present on each optionally substituted group are independently selected from C 1 -C 4 alkyl, C 1 -C 4 heteroalkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocycloalkyl, C 6 -C 10 aryl, C 5 -C 18 heteroaryl, hydroxy, C 1 -C 4 alkoxy, cyano, halo, -C(=O)OR a, C 1 -C 4 fluoroalkyl and -N(R a) 2, wherein each R a is independently hydrogen, C 1 -C 10 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 10 heteroalkyl, C 3 -C 10 cycloalkyl, C 3 -C 10 heterocycloalkyl, C 3 -C 10 heterocycloalkylC 1 -C 4 alkyl, C 6 -C 10 aryl, C 6 -C 10 arylC 1 -C 4 alkyl, C 5 -C 18 heteroaryl, or C 5 -C 18 heteroarylC 1 -C 4 alkyl.