mhurhangee/ep-ind-claims huggingface dataset:
A compound of formula: R 1 -Lys-Ala-Gln-Lys-Arg-Phe-R 2 wherein R 1 is selected from the group consisting of H, C 1 -C 24 alkyloyl, C 2 -C 24 alkenyloyl, and C 6 -C 10 aryl; R 2 is selected from the group consisting of -OR 3, -SR 3, -NR 3 R 4, and a rest of formula -NH-(CH 2) 3 -(OCH 2 CH 2) n -CH 2 -NH 2 wherein n is an integer from 1 to 6; R 3 and R 4 are independently selected from the group consisting of H; C 1 -C 6 alkyl; C 3 -C 8 cycloalkyl; C 6 -C 10 aryl; C 6 -C 10 aryl-C 1 -C 6 alkyl; 5, 6 or 7 membered heterocycle containing 1, 2 or 3 heteroatoms in the ring independently selected from the group consisting of N, O and S; 5 or 6 membered monocyclic heteroaryl containing 1, 2, 3 or 4 heteroatoms in the ring independently selected from the group consisting of N, O and S; 8, 9 or 10 membered bicyclic heteroaryl containing 1, 2, 3 or 4 heteroatoms independently selected from the group consisting ofN, O and S; heteroaryl-C 1 -C 3 alkyl, wherein the heteroaryl is monocyclic or bicyclic as previously defined; its stereoisomers, its cosmetically acceptable salts, or mixtures thereof R 1 is selected from the group consisting of H, C 1 -C 24 alkyloyl, C 2 -C 24 alkenyloyl, and C 6 -C 10 aryl; R 2 is selected from the group consisting of -OR 3, -SR 3, -NR 3 R 4, and a rest of formula -NH-(CH 2) 3 -(OCH 2 CH 2) n -CH 2 -NH 2 wherein n is an integer from 1 to 6; R 3 and R 4 are independently selected from the group consisting of H; C 1 -C 6 alkyl; C 3 -C 8 cycloalkyl; C 6 -C 10 aryl; C 6 -C 10 aryl-C 1 -C 6 alkyl; 5, 6 or 7 membered heterocycle containing 1, 2 or 3 heteroatoms in the ring independently selected from the group consisting of N, O and S; 5 or 6 membered monocyclic heteroaryl containing 1, 2, 3 or 4 heteroatoms in the ring independently selected from the group consisting of N, O and S; 8, 9 or 10 membered bicyclic heteroaryl containing 1, 2, 3 or 4 heteroatoms independently selected from the group consisting ofN, O and S; heteroaryl-C 1 -C 3 alkyl, wherein the heteroaryl is monocyclic or bicyclic as previously defined;
A composition for use in treating Pompe disease, wherein the composition comprises a rAAV2/9 vector, wherein the rAAV2/9 vector comprises a heterologous nucleic acid molecule encoding acid α-glucosidase, wherein the heterologous nucleic acid is operably linked to a desmin promoter, a myocyte specific enhancer factor 2 enhancer element, and a MyoD enhancer element, wherein the composition is administered to a subject in need thereof via intramuscular, intrathoracic, intraspinal, intrathecal, intracisternal, or intravenous injection.
Thermoplastic elastomer composition comprising a mixture of acrylate rubber and polyurethane, wherein the weight ratio of acrylate rubber to polyurethane is 8:2 to 5:5, and wherein the acrylate rubber comprises ethyl acrylate, butyl acrylate and/or methoxyethyl acrylate.
Clutch arrangement, for example for a drive train of a vehicle, having the following features: a first component which is disc-shaped at least in sections and has a first friction face on the disc-shaped section; a second component which is disc-shaped at least in sections and has a second friction face on the disc-shaped section, the first and the second friction face (230, 240) being configured and arranged so as to be capable of being brought into a frictional engagement with one another and of being in contact with a liquid medium during operation; and a delivery component which comprises a delivery face for the liquid medium, and which is coupled substantially fixedly to a drive component so as to rotate with it in such a way that the delivery face brings about a flow of the liquid medium in the case of a rotation relative to the liquid medium; the delivery component being in engagement with the first component via the delivery face in such a way that, in the case of a rotation of the delivery component, the first component is set in rotation; and the first component being an internal fin. a first component which is disc-shaped at least in sections and has a first friction face on the disc-shaped section; a second component which is disc-shaped at least in sections and has a second friction face on the disc-shaped section, the first and the second friction face (230, 240) being configured and arranged so as to be capable of being brought into a frictional engagement with one another and of being in contact with a liquid medium during operation; and a delivery component which comprises a delivery face for the liquid medium, and which is coupled substantially fixedly to a drive component so as to rotate with it in such a way that the delivery face brings about a flow of the liquid medium in the case of a rotation relative to the liquid medium; the delivery component being in engagement with the first component via the delivery face in such a way that, in the case of a rotation of the delivery component, the first component is set in rotation; and the first component being an internal fin.
A chip package, comprising: semiconductor dies (110-1, 110-2, 110-3) arranged in a stack in a vertical direction, which is substantially perpendicular to a plane of a first semiconductor die in the stack, wherein each semiconductor die, after the first semiconductor die, is offset in a horizontal direction in the plane by an offset value from an immediately preceding semiconductor die in the stack, thereby defining a stepped terrace at one side of the stack, and wherein a surface of each of the semiconductor dies in the stepped terrace includes two rows of first pads approximately parallel to edges of the semiconductor dies; connectors electrically and mechanically coupled to the first pads; and a ramp component positioned on the one side of the stack, wherein the ramp component is approximately parallel to a direction along the stepped terrace, which is between the horizontal direction and the vertical direction; wherein the ramp component has a surface that includes second pads arranged in at least two rows of second pads for each of the semiconductor dies; wherein the connectors are electrically and mechanically coupled to the second pads; wherein the ramp component includes negative features disposed on the surface and arranged in rows; and wherein at least one of said two rows of second pads for each of the semiconductor dies is disposed in one of the rows of negative features. semiconductor dies (110-1, 110-2, 110-3) arranged in a stack in a vertical direction, which is substantially perpendicular to a plane of a first semiconductor die in the stack, wherein each semiconductor die, after the first semiconductor die, is offset in a horizontal direction in the plane by an offset value from an immediately preceding semiconductor die in the stack, thereby defining a stepped terrace at one side of the stack, and wherein a surface of each of the semiconductor dies in the stepped terrace includes two rows of first pads approximately parallel to edges of the semiconductor dies; connectors electrically and mechanically coupled to the first pads; and a ramp component positioned on the one side of the stack, wherein the ramp component is approximately parallel to a direction along the stepped terrace, which is between the horizontal direction and the vertical direction; wherein the ramp component has a surface that includes second pads arranged in at least two rows of second pads for each of the semiconductor dies; wherein the connectors are electrically and mechanically coupled to the second pads; wherein the ramp component includes negative features disposed on the surface and arranged in rows; and wherein at least one of said two rows of second pads for each of the semiconductor dies is disposed in one of the rows of negative features.
A processor comprising: configuration storage to store an indicator to enable a restricted speculative execution mode of operation of the processor, wherein the processor is to restrict speculative execution when operating in restricted speculative execution mode; an execution circuit to perform speculative execution; and a controller to restrict speculative execution by the execution circuit when the restricted speculative execution mode is enabled; wherein the controller is to determine that a speculation frontier, which is a frontier in an order of operations, is reached and to restrict the speculative execution until the speculation frontier is reached and to allow the speculative execution after the speculation frontier is reached. configuration storage to store an indicator to enable a restricted speculative execution mode of operation of the processor, wherein the processor is to restrict speculative execution when operating in restricted speculative execution mode; an execution circuit to perform speculative execution; and a controller to restrict speculative execution by the execution circuit when the restricted speculative execution mode is enabled; wherein the controller is to determine that a speculation frontier, which is a frontier in an order of operations, is reached and to restrict the speculative execution until the speculation frontier is reached and to allow the speculative execution after the speculation frontier is reached.
Method for controlling a headlight arrangement for a vehicle, the headlight arrangement having a right headlight and a left headlight, the right headlight emitting a right light beam and the left headlight emitting a left light beam, by means of which light beams a first total light distribution can be generated, in which a central region is formed and side regions (S 1, S 2) are formed on either side of this central region, the side regions (S 1, S 2) having a greater illuminating range than the central region, in which method an initial light distribution is generated by means of the left light beam and the right light beam, at least one object is detected in front of the vehicle in the direction of travel, the position of the object being determined and the size and/or width of the object being detected, and a second total light distribution, which is a marker light, is generated when the position of the object has been determined, characterized in that in the second total light distribution, the side regions (S 1, S 2) of the first total light distribution are at least partially superimposed at the position of the object so that a superimposed region is formed in which the light intensity is made up of the light intensity of the left light beam and of the right light beam, the superimposed region being generated by tilting the light emission directions of the headlights (1, 2) about a vertical axis to the determined position, a left tilt angle for the left headlight about the vertical axis and a right tilt angle for the right headlight about the vertical axis being determined depending on the size and/or width of the object, and the left headlight being tilted by the determined left tilt angle and the right headlight being tilted by the determined right tilt angle, so that the width and/or size of the superimposed region is dependent on the width and/or size of the object. at least one object is detected in front of the vehicle in the direction of travel, the position of the object being determined and the size and/or width of the object being detected, and a second total light distribution, which is a marker light, is generated when the position of the object has been determined, characterized in that in the second total light distribution, the side regions (S 1, S 2) of the first total light distribution are at least partially superimposed at the position of the object so that a superimposed region is formed in which the light intensity is made up of the light intensity of the left light beam and of the right light beam, the superimposed region being generated by tilting the light emission directions of the headlights (1, 2) about a vertical axis to the determined position, a left tilt angle for the left headlight about the vertical axis and a right tilt angle for the right headlight about the vertical axis being determined depending on the size and/or width of the object, and the left headlight being tilted by the determined left tilt angle and the right headlight being tilted by the determined right tilt angle, so that the width and/or size of the superimposed region is dependent on the width and/or size of the object.
A device for producing substantially seamless, circumferentially closed flexible embossing or printing tape, the device comprising: a multi-part housing comprising a side wall delimiting the radially external extent of an annular mould space, a bottom wall and a lid wall delimiting the respective face-ends of the annular space; a core, delimiting the radially internal extent of the annular space; an inlet for introducing a free-flow material; and a vent for ventilating the annular space; characterized in that the side wall comprises multiple parts with a plurality of outwardly rotatable side elements arranged so as to be outwardly radially displaceable to enable the annular space to be opened in use. a multi-part housing comprising a side wall delimiting the radially external extent of an annular mould space, a bottom wall and a lid wall delimiting the respective face-ends of the annular space; a core, delimiting the radially internal extent of the annular space; an inlet for introducing a free-flow material; and a vent for ventilating the annular space; characterized in that the side wall comprises multiple parts with a plurality of outwardly rotatable side elements arranged so as to be outwardly radially displaceable to enable the annular space to be opened in use.
Electric safety braking device which is intended for an electric traction vehicle, in particular a rail vehicle comprising: a rotating electromechanical machine having permanent magnets with electric terminals (13, 14, 15), a resistive braking torque production device, an electromechanical commutator which is capable of reliably connecting the electric terminals (13, 14, 15) of the machine to the braking torque production device, characterised in that the resistive braking torque production device comprises, on the one hand, a bipolar assembly of at least one dissipative resistor, the assembly having two single connection terminals and forming a common terminal bipolar electric output load for all the terminals (13, 14, 15) of the machine and, on the other hand, means for converting the currents from all the terminals (13, 14, 15) into a single current which is supplied to the two single terminals of the bipolar assembly, the conversion means having no active power switches, the conversion means being constituted by a diode bridge rectifier which is interposed between the electromechanical commutator and the bipolar assembly of at least one dissipative resistor (122, 146, 156, 158), the dissipative resistor (122, 146, 156, 158) being connected between two single outputs (124, 126) of the diode bridge rectifier. a rotating electromechanical machine having permanent magnets with electric terminals (13, 14, 15), a resistive braking torque production device, an electromechanical commutator which is capable of reliably connecting the electric terminals (13, 14, 15) of the machine to the braking torque production device, characterised in that the resistive braking torque production device comprises, on the one hand, a bipolar assembly of at least one dissipative resistor, the assembly having two single connection terminals and forming a common terminal bipolar electric output load for all the terminals (13, 14, 15) of the machine and, on the other hand, means for converting the currents from all the terminals (13, 14, 15) into a single current which is supplied to the two single terminals of the bipolar assembly, the conversion means having no active power switches, the conversion means being constituted by a diode bridge rectifier which is interposed between the electromechanical commutator and the bipolar assembly of at least one dissipative resistor (122, 146, 156, 158), the dissipative resistor (122, 146, 156, 158) being connected between two single outputs (124, 126) of the diode bridge rectifier.
A combination of medicaments for use in treating cancer or neoplastic disease, comprising a therapeutically effective amount of at least one bromodomain and extra-terminal protein inhibitor, and a therapeutically effective amount of at least one chemotherapeutic agent that does not directly inhibit BET, wherein the at least one bromodomain and extra-terminal protein inhibitor is 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-l-one or the pharmaceutically acceptable salt thereof, and the chemotherapeutic agent is temozolomide.
A device for dosing coffee comprising a main body provided with a support base, an upper cover and a compact unit comprising at least three internally hollow substantially cylindrical integral chambers able to contain at their inside coffee doses and extending between said support base and said cover, wherein said main body is provided with a first opening formed in said cover and a second opening formed in said support base and wherein said compact unit is able to rotate around an axis so that said chambers are able to sequentially assume various configurations for which, in each of said configurations, the upper part of only one of said three chambers is located in correspondence of said first opening to be subjected to a coffee dose charging action and only another one of the remaining chambers is located in correspondence of said second opening to be subjected to a coffee dose discharging action, wherein the device for dosing coffee further comprises a motor designed to activate said rotation of said compact unit with said chambers, characterized in that said motor is fixed on said support base of said main body, substantially around the center thereof, and housed in said hollow area radially surrounded by said chambers.
A biomass gasification gas purification system (10B;10C) comprising: a dust removal apparatus arranged to filter soot and dust from biomass gasification gas obtained through the gasification of biomass using a biomass gasification furnace; a desulfurization apparatus arranged to remove a sulfur oxide component in the filtered biomass gasification gas; at least two pre-reformation reactors (16A-C;16a-c) serially arranged to reform the tar component in the biomass gasification gas after desulfurization; a cooler interposed in a diverging line, a portion of which is diverged from a supply line of the biomass gasification gas that has undergone dust removal and desulfurization for cooling the diverged portion of the biomass gasification gas; and a supply line (L3,L4) arranged to supply the cooled biomass gasification gas between the pre-reformation reactors (16A-C;16a-c), respectively. a dust removal apparatus arranged to filter soot and dust from biomass gasification gas obtained through the gasification of biomass using a biomass gasification furnace; a desulfurization apparatus arranged to remove a sulfur oxide component in the filtered biomass gasification gas; at least two pre-reformation reactors (16A-C;16a-c) serially arranged to reform the tar component in the biomass gasification gas after desulfurization; a cooler interposed in a diverging line, a portion of which is diverged from a supply line of the biomass gasification gas that has undergone dust removal and desulfurization for cooling the diverged portion of the biomass gasification gas; and a supply line (L3,L4) arranged to supply the cooled biomass gasification gas between the pre-reformation reactors (16A-C;16a-c), respectively.
Autoantigens for in vitro diagnosis of NMO (neuromyelitis optica) consisting of an amino acid sequence (polypeptide), which contain the following partial sequences of groups i.) SDRPTARRWGKCGP, ii.) GGTEKPLPVD, iii.) CDSKRTD, iv.) NPARSFG, and v.) DVDRGEEKKGKDQSGE, and a partial sequence of group vi.) specifically EFKRRFKEAFSKAA or EFKRRFKEAFSKAAQQ or EFKRRFKEAFSKAAQQTKG and comprise at least one spacer which contains 2 to 30 amino acids, preferably 2 to 20 amino acids, particularly preferably 2 to 10 amino acids, and the polypeptide that is obtained consists of at most 250 amino acids, wherein the spacer does not contain any amino acid sequence of SEQ ID No. 1.
A turbine shroud comprising a plurality of carrier segments (24, 224) comprising metallic material and arranged circumferentially adjacent to one another around an axis, a plurality of blade track segments (26, 226) comprising ceramic-matrix composite material and arranged circumferentially adjacent to one another around the axis, each blade track segment (26, 226) coupled to one of the carrier segments (24, 224), characterized by a plurality of impingement tubes (28, 228), each impingement tube (28, 228) extending axially into one of the carrier segments (24, 224) through tube receivers and configured to direct a flow of cooling air toward a radially-outward facing side (53, 253) of the blade track segment (26, 226), wherein each carrier segment (24, 224) is formed to include a tube receiver configured to receive one of the impingement tubes (28, 228) to hold the impingement tubes (28, 228) in place relative to the carrier segment (24, 224).
An angle adjustment device, comprising: an unlocking cam, a ratchet wheel provided with internal teeth, a plurality of sliding blocks distributed along the circumferential direction and provided with external teeth, a plurality of expansion and contraction blocks corresponding to the plurality of sliding blocks, and a first elastic piece and a sliding groove plate that is rotatable relative to the ratchet wheel; wherein the plurality of expansion and contraction blocks is configured to respectively drive the plurality of sliding blocks to move outwards in radial directions so as to allow the internal teeth to be meshed with the external teeth; and a second elastic piece is arranged between adjacent expansion and contraction blocks, and two ends of the second elastic piece along a deformation direction are respectively connected with the unlocking cam and the plurality of expansion and contraction blocks, and wherein one end of the first elastic piece is connected to the sliding groove plate, and the other end of the first elastic piece is directly or indirectly connected to the unlocking cam so as to allow the torque of the unlocking cam to be transmitted. an unlocking cam, a ratchet wheel provided with internal teeth, a plurality of sliding blocks distributed along the circumferential direction and provided with external teeth, a plurality of expansion and contraction blocks corresponding to the plurality of sliding blocks, and a first elastic piece and a sliding groove plate that is rotatable relative to the ratchet wheel; wherein the plurality of expansion and contraction blocks is configured to respectively drive the plurality of sliding blocks to move outwards in radial directions so as to allow the internal teeth to be meshed with the external teeth; and a second elastic piece is arranged between adjacent expansion and contraction blocks, and two ends of the second elastic piece along a deformation direction are respectively connected with the unlocking cam and the plurality of expansion and contraction blocks, and wherein one end of the first elastic piece is connected to the sliding groove plate, and the other end of the first elastic piece is directly or indirectly connected to the unlocking cam so as to allow the torque of the unlocking cam to be transmitted.
A quinary alloy consisting of [Cu + Mn + Ni] 50 to 95 at.% with the balance being Al and Zn, wherein the Cu, Mn and Ni are present in equal atomic percentages.