A system for enhanced surgical navigation comprising: a computing device including a processor, the processor of the computing device configured to: import a navigation path generated from a first data set of computed tomography images of a branched luminal network previously acquired, the navigation path defining a path to be followed through the branched luminal network to a target; display the path of the navigation path on a graphical user interface for a first navigation to the target by following the path and for placement of a plurality of markers in tissue proximate the target; and acquire a second data set of computed tomography images of the branched luminal network including the plurality of markers; generate a three-dimensional model of the branched luminal network from the second data set of computed tomography images; plan a second navigation path through the branched luminal network using the three-dimensional model generated, the second navigation path defining a second path to be followed through the branched luminal network to the target for a second navigation to the target; and an imaging device configured to capture fluoroscopic data of tissue proximate the plurality of markers, wherein the fluoroscopic data comprises at least one fluoroscopic image, wherein the processor of the computing device is further configured to: register the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the fluoroscopic data and the marker position and orientation within the second data set of computed tomography images; identify a two-dimensional slice, of the three-dimensional model, having a marker position and orientation corresponding to a marker position and orientation within the fluoroscopic data; create a composite fluoroscopic image including: the fluoroscopic data; the second data set of computed tomography images, including an object viewable in the second data set of computed tomography images that is not viewable in the fluoroscopic data; and the branched luminal network from the second data set of computed tomography images; display the composite fluoroscopic image on the graphical user interface. import a navigation path generated from a first data set of computed tomography images of a branched luminal network previously acquired, the navigation path defining a path to be followed through the branched luminal network to a target; display the path of the navigation path on a graphical user interface for a first navigation to the target by following the path and for placement of a plurality of markers in tissue proximate the target; and acquire a second data set of computed tomography images of the branched luminal network including the plurality of markers; generate a three-dimensional model of the branched luminal network from the second data set of computed tomography images; plan a second navigation path through the branched luminal network using the three-dimensional model generated, the second navigation path defining a second path to be followed through the branched luminal network to the target for a second navigation to the target; and an imaging device configured to capture fluoroscopic data of tissue proximate the plurality of markers, wherein the fluoroscopic data comprises at least one fluoroscopic image, wherein the processor of the computing device is further configured to: register the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the fluoroscopic data and the marker position and orientation within the second data set of computed tomography images; identify a two-dimensional slice, of the three-dimensional model, having a marker position and orientation corresponding to a marker position and orientation within the fluoroscopic data; create a composite fluoroscopic image including: the fluoroscopic data; the second data set of computed tomography images, including an object viewable in the second data set of computed tomography images that is not viewable in the fluoroscopic data; and the branched luminal network from the second data set of computed tomography images; display the composite fluoroscopic image on the graphical user interface. register the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the fluoroscopic data and the marker position and orientation within the second data set of computed tomography images; identify a two-dimensional slice, of the three-dimensional model, having a marker position and orientation corresponding to a marker position and orientation within the fluoroscopic data; create a composite fluoroscopic image including: the fluoroscopic data; the second data set of computed tomography images, including an object viewable in the second data set of computed tomography images that is not viewable in the fluoroscopic data; and the branched luminal network from the second data set of computed tomography images; the fluoroscopic data; the second data set of computed tomography images, including an object viewable in the second data set of computed tomography images that is not viewable in the fluoroscopic data; and the branched luminal network from the second data set of computed tomography images; display the composite fluoroscopic image on the graphical user interface.