A surgical instrument system, comprising: a shaft; a handle assembly releasably couplable to the shaft, wherein the handle assembly comprises: a disposable outer housing defining a sterile barrier, the disposable outer housing comprising: a first housing-portion; and a second housing-portion movable relative to the first housing-portion between an open configuration and a closed configuration; and a control inner core receivable inside the disposable outer housing in the open configuration, wherein the disposable outer housing is configured to isolate the control inner core within the sterile barrier in the closed configuration; an end effector releasably couplable to the shaft; and an electrical interface assembly configured to transmit at least one of data signal and power between the control inner core and the end effector, the electrical interface assembly comprising: a first interface portion on a first side of the sterile barrier; a second interface portion on a second side of the sterile barrier opposite the first side, wherein the first interface portion is configured to form a wireless electrical interface with the second interface portion to facilitate a wireless transmission of the at least one of data signal and power between the control inner core and second interface portion; and an exteriorly-mounted wiring connection, wherein the exteriorly-mounted wiring connection is separately-attachable to the second interface portion to facilitate a wired transmission of the at least one of data signal and power between the second interface portion and the end effector. a shaft; a handle assembly releasably couplable to the shaft, wherein the handle assembly comprises: a disposable outer housing defining a sterile barrier, the disposable outer housing comprising: a first housing-portion; and a second housing-portion movable relative to the first housing-portion between an open configuration and a closed configuration; and a control inner core receivable inside the disposable outer housing in the open configuration, wherein the disposable outer housing is configured to isolate the control inner core within the sterile barrier in the closed configuration; a disposable outer housing defining a sterile barrier, the disposable outer housing comprising: a first housing-portion; and a second housing-portion movable relative to the first housing-portion between an open configuration and a closed configuration; and a first housing-portion; and a second housing-portion movable relative to the first housing-portion between an open configuration and a closed configuration; and a control inner core receivable inside the disposable outer housing in the open configuration, wherein the disposable outer housing is configured to isolate the control inner core within the sterile barrier in the closed configuration; an end effector releasably couplable to the shaft; and an electrical interface assembly configured to transmit at least one of data signal and power between the control inner core and the end effector, the electrical interface assembly comprising: a first interface portion on a first side of the sterile barrier; a second interface portion on a second side of the sterile barrier opposite the first side, wherein the first interface portion is configured to form a wireless electrical interface with the second interface portion to facilitate a wireless transmission of the at least one of data signal and power between the control inner core and second interface portion; and an exteriorly-mounted wiring connection, wherein the exteriorly-mounted wiring connection is separately-attachable to the second interface portion to facilitate a wired transmission of the at least one of data signal and power between the second interface portion and the end effector. a first interface portion on a first side of the sterile barrier; a second interface portion on a second side of the sterile barrier opposite the first side, wherein the first interface portion is configured to form a wireless electrical interface with the second interface portion to facilitate a wireless transmission of the at least one of data signal and power between the control inner core and second interface portion; and an exteriorly-mounted wiring connection, wherein the exteriorly-mounted wiring connection is separately-attachable to the second interface portion to facilitate a wired transmission of the at least one of data signal and power between the second interface portion and the end effector.