An atomic-to-nanoscale matter emission/flow regulation device comprising at least a first nanodroplet generation/control device having a front side, a back side and a first reservoir disposed in between the front side and the back side for holding matter to be extracted, the first nanodroplet generation/control device comprising at least a first nanodroplet column system comprising: an upper portion of the first reservoir; a first electrostatic lens (e-lens) disposed in between the upper portion of the first reservoir and the front side of the first nanodroplet generation/control device, the first e-lens including at least a first set of at least first and second electrodes that are laterally separated from one another by a first lateral gap having a gap width; and a first nozzle disposed in between the first e-lens and the upper portion of the first reservoir and being separated from the first e-lens by a first e-lens-to-filament gap, the first nozzle having an inlet disposed in a surface of the upper portion of the first reservoir and an exit side disposed in the first e-lens-to-filament gap, the exit side of the first nozzle having a first nanodroplet orifice through which nanodroplets generated from matter held in the first reservoir are extracted out of the first reservoir through the first nanodroplet orifice when a first set of preselected voltage signals are applied to the first set of at least first and second electrodes, the first nozzle being precisely aligned with the first lateral gap and the inlet having a first nozzle width equal to a distance between innermost edges of side walls of the first nozzle, the first nozzle and the first lateral gap having a common central axis that ensures that the nanodroplets extracted through the first nanodroplet orifice self-align with the first lateral gap, the side walls of the first nozzle extending away from the common central axis of the first nozzle and the first e-lens at the exit side, wherein the side walls of the first nozzle are sloped or stepped, the first nozzle width being less than or equal to 300 nanometers. an upper portion of the first reservoir; a first electrostatic lens (e-lens) disposed in between the upper portion of the first reservoir and the front side of the first nanodroplet generation/control device, the first e-lens including at least a first set of at least first and second electrodes that are laterally separated from one another by a first lateral gap having a gap width; and a first nozzle disposed in between the first e-lens and the upper portion of the first reservoir and being separated from the first e-lens by a first e-lens-to-filament gap, the first nozzle having an inlet disposed in a surface of the upper portion of the first reservoir and an exit side disposed in the first e-lens-to-filament gap, the exit side of the first nozzle having a first nanodroplet orifice through which nanodroplets generated from matter held in the first reservoir are extracted out of the first reservoir through the first nanodroplet orifice when a first set of preselected voltage signals are applied to the first set of at least first and second electrodes, the first nozzle being precisely aligned with the first lateral gap and the inlet having a first nozzle width equal to a distance between innermost edges of side walls of the first nozzle, the first nozzle and the first lateral gap having a common central axis that ensures that the nanodroplets extracted through the first nanodroplet orifice self-align with the first lateral gap, the side walls of the first nozzle extending away from the common central axis of the first nozzle and the first e-lens at the exit side, wherein the side walls of the first nozzle are sloped or stepped, the first nozzle width being less than or equal to 300 nanometers.