An earth-boring tool, comprising: a body with a rotational axis, the body having a crown; blades (130, 132) extending outward from the body between the rotational axis and a periphery of the earth-boring tool including a cone region located immediately around the rotational axis, a nose region located adjacent to the cone region on a side of the cone region opposite the rotational axis, a shoulder region located adjacent to the nose region on a side of the nose region opposite the cone region and a gage region located adjacent to the shoulder region on a side of the shoulder region opposite the nose region; and cutting elements secured to the blades (130, 132); wherein the blades (130, 132) include a set of first blades and a set of rotationally adjacent second blades, wherein each first blade exhibits a first substantially constant radius of curvature over an entirety of a radial extent of the first blade, and each first blade extends from the cone region radially outward over the crown to the gage region, wherein each second blade exhibits a second substantially constant radius of curvature over an entirety of a radial extent of the second blade, and each second blade extends from the nose region or the shoulder region radially outward over the crown to the gage region, wherein the first radius of curvature is different from the second radius of curvature over the entirety of the radial extend of the second blade, and wherein a variance index of the earth-boring tool measured between rotationally leading surfaces of the first and second blades (130, 132) is between 5% and 30%, wherein the variance index is a unitless number representing an average percent change in angular distance measured by determining an included angle between a rotationally leading surface of rotationally leading first blade and an adjacent, rotationally trailing second blade within a radial range of the rotationally overlapping portions of the blades, wherein a value of the first radius of curvature is between 200% and 7,500% of a value of the second radius of curvature, wherein the value of the first radius of curvature is greater than 15 inches (38 cm) and the value of the second radius of curvature is between 1 inch (2.5 cm) and 12 inches (30 cm). a body with a rotational axis, the body having a crown; blades (130, 132) extending outward from the body between the rotational axis and a periphery of the earth-boring tool including a cone region located immediately around the rotational axis, a nose region located adjacent to the cone region on a side of the cone region opposite the rotational axis, a shoulder region located adjacent to the nose region on a side of the nose region opposite the cone region and a gage region located adjacent to the shoulder region on a side of the shoulder region opposite the nose region; and cutting elements secured to the blades (130, 132); wherein the blades (130, 132) include a set of first blades and a set of rotationally adjacent second blades, wherein each first blade exhibits a first substantially constant radius of curvature over an entirety of a radial extent of the first blade, and each first blade extends from the cone region radially outward over the crown to the gage region, wherein each second blade exhibits a second substantially constant radius of curvature over an entirety of a radial extent of the second blade, and each second blade extends from the nose region or the shoulder region radially outward over the crown to the gage region, wherein the first radius of curvature is different from the second radius of curvature over the entirety of the radial extend of the second blade, and wherein a variance index of the earth-boring tool measured between rotationally leading surfaces of the first and second blades (130, 132) is between 5% and 30%, wherein the variance index is a unitless number representing an average percent change in angular distance measured by determining an included angle between a rotationally leading surface of rotationally leading first blade and an adjacent, rotationally trailing second blade within a radial range of the rotationally overlapping portions of the blades, wherein a value of the first radius of curvature is between 200% and 7,500% of a value of the second radius of curvature, wherein the value of the first radius of curvature is greater than 15 inches (38 cm) and the value of the second radius of curvature is between 1 inch (2.5 cm) and 12 inches (30 cm).