Use of a compound comprising, preferably consisting of, two hydrophobic domains attached to a hydrophilic domain, wherein the two hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the two hydrophobic domains each comprise cholesterol, and wherein the hydrophilic domain comprises a polyethylene glycol moiety, for stabilization of a cell, wherein stabilization of a cell is a higher viability of a cell compared to the viability of a control cell without application of said compound under shear stress conditions, and wherein the hydrophilic domain comprises a compound of Formula: X1-[A1- n] k1 -Z-[A2- n] k2 -X2, wherein Z is linear polyethylene glycol moiety containing 1 to 50, preferably 4-30 -O-CH 2 -CH 2 - moieties, wherein the polyethylene glycol moiety optionally comprises 1 or more spacer moieties SP connecting two -O-CH 2 -CH 2 - moieties, and wherein the linear PEG moiety optionally comprises a linker moiety L3 at one or both ends, each L1 is a linker moiety selected independently from each other from the group consisting of a phosphate, amide, carbamate, and ester group, each n is either 0 or 1, selected independently from each other, A1 and A2 are bifunctional or trifunctional moieties selected independently from each other, with the proviso that at least one A1 or A2 is trifunctional, wherein the trifunctional moiety is selected from lysine, serine, serinol, -O-CH 2 -CH((CH 2) 4 -NH 2)-CH 2 -, a glycerol, and a 1,3 diaminoglycerol moiety, wherein the bifunctional moiety is selected from the group consisting of a phosphate group, carbamate group, amide group, a moiety comprising a nucleobase, even more preferably dT, and a linear alkyl group having 1 to 10 C atoms and which alkyl chain contains functional groups at the terminal C-atoms, in particular independently selected from amine, carbonyl, hydroxyl, thiol, carbonic acid groups, k1 and k2 are integers between 0 and 10, selected independently from each other, with the proviso that at least one of k1 and k2 is not 0, X1 and X2 are independently selected from hydrogen or a protecting group, L3 is independently selected from a linear alkyl or alkenyl chain with 1 to 10 C atoms, which is optionally (i) interrupted by 1 to 3 N, O or S atoms, and/or (ii) substituted by 1 to 4 hydroxyl, carbonyl, amino or thiol groups, the 1 or more spacer moieties SP are phosphate, and wherein the two or more hydrophobic domains are covalently bound to said hydrophilic domain via the trifunctional domains, or a salt thereof. Z is linear polyethylene glycol moiety containing 1 to 50, preferably 4-30 -O-CH 2 -CH 2 - moieties, wherein the polyethylene glycol moiety optionally comprises 1 or more spacer moieties SP connecting two -O-CH 2 -CH 2 - moieties, and wherein the linear PEG moiety optionally comprises a linker moiety L3 at one or both ends, each L1 is a linker moiety selected independently from each other from the group consisting of a phosphate, amide, carbamate, and ester group, each n is either 0 or 1, selected independently from each other, A1 and A2 are bifunctional or trifunctional moieties selected independently from each other, with the proviso that at least one A1 or A2 is trifunctional, wherein the trifunctional moiety is selected from lysine, serine, serinol, -O-CH 2 -CH((CH 2) 4 -NH 2)-CH 2 -, a glycerol, and a 1,3 diaminoglycerol moiety, wherein the bifunctional moiety is selected from the group consisting of a phosphate group, carbamate group, amide group, a moiety comprising a nucleobase, even more preferably dT, and a linear alkyl group having 1 to 10 C atoms and which alkyl chain contains functional groups at the terminal C-atoms, in particular independently selected from amine, carbonyl, hydroxyl, thiol, carbonic acid groups, k1 and k2 are integers between 0 and 10, selected independently from each other, with the proviso that at least one of k1 and k2 is not 0, X1 and X2 are independently selected from hydrogen or a protecting group, L3 is independently selected from a linear alkyl or alkenyl chain with 1 to 10 C atoms, which is optionally (i) interrupted by 1 to 3 N, O or S atoms, and/or (ii) substituted by 1 to 4 hydroxyl, carbonyl, amino or thiol groups, the 1 or more spacer moieties SP are phosphate, and wherein the two or more hydrophobic domains are covalently bound to said hydrophilic domain via the trifunctional domains, or a salt thereof.