A system, comprising: a first set of electrodes disposable near cardiac tissue of a heart; a second set of electrodes (232, 234) disposed in contact with patient anatomy; a signal generator configured to generate a pulse waveform, the signal generator coupled to the first set of electrodes and configured to repeatedly deliver the pulse waveform to the first set of electrodes, the first set of electrodes configured to generate a pulsed electric field in response to the delivery of the pulse waveform to ablate the cardiac tissue; a protection device (250, 300) configured to selectively couple and decouple an electronic device to the second set of the electrodes, the protection device (250, 300) including: a switch component to switch between a conducting state in which the electronic device is coupled to the second set of electrodes (232, 234) and a non-conducting state in which the electronic device is decoupled from the second set of electrodes (232, 234), wherein the switch component is a pair of metal oxide semiconductor field effect transistors (MOSFETs) (310, 320) having a common source terminal and gate terminals coupled to one or more isolated gate drive circuits (330, 340), the one or more isolated gate drive circuits (330, 340) configured to deliver a control signal to the gate terminals to switch the pair of MOSFETs (310, 320) between the conducting state and the non-conducting state; and a control element coupled to the protection device (250, 300) and configured to control the protection device (250, 300) to decouple the electronic device from the second set of electrodes (232, 234) during intervals of time beginning before and ending after each delivery of the pulse waveform to the first set of electrodes. a first set of electrodes disposable near cardiac tissue of a heart; a second set of electrodes (232, 234) disposed in contact with patient anatomy; a signal generator configured to generate a pulse waveform, the signal generator coupled to the first set of electrodes and configured to repeatedly deliver the pulse waveform to the first set of electrodes, the first set of electrodes configured to generate a pulsed electric field in response to the delivery of the pulse waveform to ablate the cardiac tissue; a protection device (250, 300) configured to selectively couple and decouple an electronic device to the second set of the electrodes, the protection device (250, 300) including: a switch component to switch between a conducting state in which the electronic device is coupled to the second set of electrodes (232, 234) and a non-conducting state in which the electronic device is decoupled from the second set of electrodes (232, 234), wherein the switch component is a pair of metal oxide semiconductor field effect transistors (MOSFETs) (310, 320) having a common source terminal and gate terminals coupled to one or more isolated gate drive circuits (330, 340), the one or more isolated gate drive circuits (330, 340) configured to deliver a control signal to the gate terminals to switch the pair of MOSFETs (310, 320) between the conducting state and the non-conducting state; and a switch component to switch between a conducting state in which the electronic device is coupled to the second set of electrodes (232, 234) and a non-conducting state in which the electronic device is decoupled from the second set of electrodes (232, 234), wherein the switch component is a pair of metal oxide semiconductor field effect transistors (MOSFETs) (310, 320) having a common source terminal and gate terminals coupled to one or more isolated gate drive circuits (330, 340), the one or more isolated gate drive circuits (330, 340) configured to deliver a control signal to the gate terminals to switch the pair of MOSFETs (310, 320) between the conducting state and the non-conducting state; and a control element coupled to the protection device (250, 300) and configured to control the protection device (250, 300) to decouple the electronic device from the second set of electrodes (232, 234) during intervals of time beginning before and ending after each delivery of the pulse waveform to the first set of electrodes.