A process for the preparation of a compound comprising Formula, the process comprising: B. contacting a compound comprising Formula with a phosphorylating agent comprising Z in the presence of a proton acceptor to form a compound comprising Formula; C. contacting the compound comprising Formula with water to form a compound comprising Formula and HZ wherein Step C further comprises (i) a first partitioning step wherein the addition of the water leads to formation of an organic phase and an aqueous phase, the organic phase comprising the compound comprising Formula and the aqueous phase comprising impurities such as HZ, and the aqueous layer of the mixture is removed from the mixture, removing impurities; and (ii) a second partitioning step of the reaction mixture into two immiscible organic phases by adding a non-polar hydrocarbon solvent selected from the group consisting of heptane, pentane, hexane, octane, and cyclopentane and a water-miscible polar hydrocarbon solvent selected from the group consisting of methanol, ethanol, and propanol, the polar hydrocarbon solvent further comprising a concentration of water from 1% to 25%, separating the reaction mixture into a polar hydrocarbon solvent phase comprising the compound comprising Formula and a non-polar hydrocarbon solvent phase comprising at least one organic side product of the reaction process; D. contacting the compound comprising Formula with a proton acceptor comprising at least one metal ion to form a compound comprising Formula, the proton acceptor being selected from the group consisting of a metal hydroxide, metal bicarbonate, and metal carbonate; and E. deprotecting the compound comprising Formula to form the compound comprising Formula according to the following reaction scheme: wherein: R p is a protecting group; Z is halogen; and M is selected from the group consisting of Group IA, Group IIA, and transition metal ions. B. contacting a compound comprising Formula with a phosphorylating agent comprising Z in the presence of a proton acceptor to form a compound comprising Formula; C. contacting the compound comprising Formula with water to form a compound comprising Formula and HZ wherein Step C further comprises (i) a first partitioning step wherein the addition of the water leads to formation of an organic phase and an aqueous phase, the organic phase comprising the compound comprising Formula and the aqueous phase comprising impurities such as HZ, and the aqueous layer of the mixture is removed from the mixture, removing impurities; and (ii) a second partitioning step of the reaction mixture into two immiscible organic phases by adding a non-polar hydrocarbon solvent selected from the group consisting of heptane, pentane, hexane, octane, and cyclopentane and a water-miscible polar hydrocarbon solvent selected from the group consisting of methanol, ethanol, and propanol, the polar hydrocarbon solvent further comprising a concentration of water from 1% to 25%, separating the reaction mixture into a polar hydrocarbon solvent phase comprising the compound comprising Formula and a non-polar hydrocarbon solvent phase comprising at least one organic side product of the reaction process; (i) a first partitioning step wherein the addition of the water leads to formation of an organic phase and an aqueous phase, the organic phase comprising the compound comprising Formula and the aqueous phase comprising impurities such as HZ, and the aqueous layer of the mixture is removed from the mixture, removing impurities; and (ii) a second partitioning step of the reaction mixture into two immiscible organic phases by adding a non-polar hydrocarbon solvent selected from the group consisting of heptane, pentane, hexane, octane, and cyclopentane and a water-miscible polar hydrocarbon solvent selected from the group consisting of methanol, ethanol, and propanol, the polar hydrocarbon solvent further comprising a concentration of water from 1% to 25%, separating the reaction mixture into a polar hydrocarbon solvent phase comprising the compound comprising Formula and a non-polar hydrocarbon solvent phase comprising at least one organic side product of the reaction process; D. contacting the compound comprising Formula with a proton acceptor comprising at least one metal ion to form a compound comprising Formula, the proton acceptor being selected from the group consisting of a metal hydroxide, metal bicarbonate, and metal carbonate; and E. deprotecting the compound comprising Formula to form the compound comprising Formula according to the following reaction scheme: wherein: R p is a protecting group; Z is halogen; and M is selected from the group consisting of Group IA, Group IIA, and transition metal ions. R p is a protecting group; Z is halogen; and M is selected from the group consisting of Group IA, Group IIA, and transition metal ions.