A compound having the structure shown in the following formula, formula VI or a pharmaceutically acceptable salt thereof: wherein R 1 is amino C1-C4 alkyl wherein the amino is substituted by R 8 and/or R 9, R 8 and R 9 are H or C1-C4 alkyl, or, form a six-membered ring together with the nitrogen atom to which they are bonded, the said six-membered ring is selected from piperazine or piperidine, R 2 is H or C1-C4 alkyl; or R 1 and R 2 form a six-membered ring together with the nitrogen atom to which they are bonded, the said six-membered ring is selected from substituted or unsubstituted piperazine or piperidine, wherein the piperazine or piperidine is substituted by C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, phenyl, amino or halogen; R 3 is H or C1-C4 alkyl; R 4 is H or one or more substituents selected from a group consisting of C1-C4 alkyl, C5-C6 cycloalkyl, C1-C4 alkoxy, phenoxy, phenylthio and halogen at any available position(s) on the phenyl ring; X is N or C; wherein R 11 is amino C1-C4 alkyl wherein the amino is substituted by substituted by R 18 and/or R 19, R 18 and R 19 are H or C1-C4 alkyl, or, form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring is selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, R 12 is H or C1-C4 alkyl; or R 11 is R 23 is H or C1-C4 alkyl, R 22 and R 21 are H or C1-C4 alkyl, or R 22 and R 21 form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring is selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, R 20 is H or C1-C4 alkyl, R 12 is H or C1-C4 alkyl; or R 11 and R 12 form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, wherein the saturated five- or six-membered ring is substituted by C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, phenyl, amino, methylamino, dimethylamino or halogen; R 13 is H or C1-C4 alkyl; R 14 is H or one or more substituents selected from a group consisting of C1-C4 alkyl, C5-C6 cycloalkyl, C1-C4 alkoxy, phenoxy, methylthio, phenylthio, amino, methylamino, dimethylamino, hydroxy, trifluoromethyl, trifluoromethoxy, cyano or halogen at any available position(s) of the phenyl ring, preferably the above substituents which is para-monosubstituted or are disubstituted at any positions of the phenyl ring; Z is N or C. wherein R 1 is amino C1-C4 alkyl wherein the amino is substituted by R 8 and/or R 9, R 8 and R 9 are H or C1-C4 alkyl, or, form a six-membered ring together with the nitrogen atom to which they are bonded, the said six-membered ring is selected from piperazine or piperidine, R 2 is H or C1-C4 alkyl; or R 1 and R 2 form a six-membered ring together with the nitrogen atom to which they are bonded, the said six-membered ring is selected from substituted or unsubstituted piperazine or piperidine, wherein the piperazine or piperidine is substituted by C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, phenyl, amino or halogen; R 3 is H or C1-C4 alkyl; R 4 is H or one or more substituents selected from a group consisting of C1-C4 alkyl, C5-C6 cycloalkyl, C1-C4 alkoxy, phenoxy, phenylthio and halogen at any available position(s) on the phenyl ring; X is N or C; wherein R 11 is amino C1-C4 alkyl wherein the amino is substituted by substituted by R 18 and/or R 19, R 18 and R 19 are H or C1-C4 alkyl, or, form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring is selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, R 12 is H or C1-C4 alkyl; or R 11 is R 23 is H or C1-C4 alkyl, R 22 and R 21 are H or C1-C4 alkyl, or R 22 and R 21 form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring is selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, R 20 is H or C1-C4 alkyl, R 12 is H or C1-C4 alkyl; or R 11 and R 12 form a saturated five- or six-membered ring together with the nitrogen atom to which they are bonded, the said saturated five- or six-membered ring selected from a group consisting of pyrrolidine, morpholine, piperazine and piperidine, wherein the saturated five- or six-membered ring is substituted by C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, phenyl, amino, methylamino, dimethylamino or halogen; R 13 is H or C1-C4 alkyl; R 14 is H or one or more substituents selected from a group consisting of C1-C4 alkyl, C5-C6 cycloalkyl, C1-C4 alkoxy, phenoxy, methylthio, phenylthio, amino, methylamino, dimethylamino, hydroxy, trifluoromethyl, trifluoromethoxy, cyano or halogen at any available position(s) of the phenyl ring, preferably the above substituents which is para-monosubstituted or are disubstituted at any positions of the phenyl ring; Z is N or C.