A method of forming an ophthalmic aqueous pharmaceutical submicron suspension, the method comprising: providing a hydrophobic therapeutic agent in the form of particles wherein the particles have an average or mean hydrodynamic radius of at least 1 micron and wherein the therapeutic agent has a log D greater than 0.1; combining the particles of therapeutic agent with a low molecular weight charged polymer to form an admixture wherein the low molecular weight polymer includes one or more cellulose polymers that by itself or cooperatively have an average molecular weight that is less than 200,000 kilodaltons (kDa); processing the admixture to transform the particles of therapeutic agent into submicron particles of the therapeutic agent, the submicron particles of therapeutic agent having an average or mean hydrodynamic radius of less than 900 nanometers wherein the step of processing the admixture includes wet milling of the admixture; and combining the admixture with one or more excipients thereby forming the pharmaceutical submicron suspension wherein the low molecular weight charged polymer inhibits the aggregation of the particles and submicron particles during the processing or upon formation of the suspension; wherein log D is the logarithm of the ratio of the sum of the concentrations of all forms of the therapeutic agent (ionized plus un-ionized) in each of two phases, an octanol phase and a water phase; for measurements of distribution coefficient, the pH of the aqueous phase is buffered to 7.4 such that the pH is not significantly perturbed by the introduction of the compound; the logarithm of the ratio of the sum of concentrations of the solute's various forms in one solvent, to the sum of the concentrations of its forms in the other solvent is called log D. providing a hydrophobic therapeutic agent in the form of particles wherein the particles have an average or mean hydrodynamic radius of at least 1 micron and wherein the therapeutic agent has a log D greater than 0.1; combining the particles of therapeutic agent with a low molecular weight charged polymer to form an admixture wherein the low molecular weight polymer includes one or more cellulose polymers that by itself or cooperatively have an average molecular weight that is less than 200,000 kilodaltons (kDa); processing the admixture to transform the particles of therapeutic agent into submicron particles of the therapeutic agent, the submicron particles of therapeutic agent having an average or mean hydrodynamic radius of less than 900 nanometers wherein the step of processing the admixture includes wet milling of the admixture; and combining the admixture with one or more excipients thereby forming the pharmaceutical submicron suspension wherein the low molecular weight charged polymer inhibits the aggregation of the particles and submicron particles during the processing or upon formation of the suspension; wherein log D is the logarithm of the ratio of the sum of the concentrations of all forms of the therapeutic agent (ionized plus un-ionized) in each of two phases, an octanol phase and a water phase; for measurements of distribution coefficient, the pH of the aqueous phase is buffered to 7.4 such that the pH is not significantly perturbed by the introduction of the compound; the logarithm of the ratio of the sum of concentrations of the solute's various forms in one solvent, to the sum of the concentrations of its forms in the other solvent is called log D.