Method for operating a drivetrain of a motor vehicle, comprising an engine, a multi-group transmission and a clutch connected between the engine and the multi-group transmission, wherein the multi-group transmission comprises a claw-shifted main transmission as well as at least one synchronized group, specifically a synchronized upstream group and/or a synchronized downstream group, wherein a switch from a natural gearspeed into a target gearspeed is carried out without activating the closed clutch, by activating the claw-shifted main transmission and by activating a synchronized group, in such a way that: a) firstly an engine torque is decreased, wherein when a limiting value of the engine torque is reached or undershot, the claw-shifted main transmission and/or the synchronized group is activated in the direction of switching off or disengaging the actual gearspeed which is to be disengaged; b) subsequently when the engine torque is approximately zero, the claw-shifted main transmission and the synchronized group are switched off, wherein the synchronized group is moved into the neutral position or held therein; c) the engine is subsequently adjusted to a target rotational speed which is dependent on the target gear to be engaged; d) subsequently when the engine reaches the target rotational speed with a defined tolerance, the synchronized group is activated in the direction of switching on or engaging the target gear which is to be engaged, wherein synchronization of the synchronized group takes place in the process; e) subsequently when the synchronization of the synchronized group has taken place with a defined tolerance, the claw-shifted main transmission is activated in the direction of switching on or engaging the target gear which is to be engaged; f) subsequent to the switching on of the claw-shifted main transmission and of the synchronized group, the engine torque is increased again. a) firstly an engine torque is decreased, wherein when a limiting value of the engine torque is reached or undershot, the claw-shifted main transmission and/or the synchronized group is activated in the direction of switching off or disengaging the actual gearspeed which is to be disengaged; b) subsequently when the engine torque is approximately zero, the claw-shifted main transmission and the synchronized group are switched off, wherein the synchronized group is moved into the neutral position or held therein; c) the engine is subsequently adjusted to a target rotational speed which is dependent on the target gear to be engaged; d) subsequently when the engine reaches the target rotational speed with a defined tolerance, the synchronized group is activated in the direction of switching on or engaging the target gear which is to be engaged, wherein synchronization of the synchronized group takes place in the process; e) subsequently when the synchronization of the synchronized group has taken place with a defined tolerance, the claw-shifted main transmission is activated in the direction of switching on or engaging the target gear which is to be engaged; f) subsequent to the switching on of the claw-shifted main transmission and of the synchronized group, the engine torque is increased again.