mhurhangee/ep-ind-claims huggingface dataset:
A Transient Receptor Potential Melastatin 8 (TRPM8) antagonist for use in a method for treating or preventing vasomotor symptoms in a subject in need thereof, comprising: administering to the subject an effective amount of the TRPM8 antagonist; wherein the TRPM8 antagonist is represented by the following formula: wherein: the partial structure of formula: is a group of formula: Ring B is benzene or pyridine, and a partial structure of formula: is a group of formula: wherein R 1 is (a) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (b) C 3 -C 7 cycloalkyl; (c) C 1 -C 6 alkoxy; or (d) halogen, R 2d is (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (c) C 3 -C 7 cycloalkyl; or (d) C 1 -C 6 alkoxy, R 3a and R 3b are each independently (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl (in which the cycloalkyl may be optionally substituted by 1 to 3 groups selected from C 1 -C 6 alkyl and C 1 -C 6 halogenoalkyl), C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; (c) C 3 -C 7 cycloalkyl which may be optionally substituted by 1 to 7 groups selected from C 1 -C 6 alkyl, C 1 -C 6 halogenoalkyl, and halogen; (d) Ci-Ce alkoxy which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; or (e) halogen, R 3c and R 3d are hydrogen, R 5 and R 6 are hydrogen, n is 1; or a pharmaceutically acceptable salt thereof; wherein the subject is a human subject. the partial structure of formula: is a group of formula: Ring B is benzene or pyridine, and a partial structure of formula: is a group of formula: wherein R 1 is (a) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (b) C 3 -C 7 cycloalkyl; (c) C 1 -C 6 alkoxy; or (d) halogen, R 2d is (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (c) C 3 -C 7 cycloalkyl; or (d) C 1 -C 6 alkoxy, R 3a and R 3b are each independently (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl (in which the cycloalkyl may be optionally substituted by 1 to 3 groups selected from C 1 -C 6 alkyl and C 1 -C 6 halogenoalkyl), C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; (c) C 3 -C 7 cycloalkyl which may be optionally substituted by 1 to 7 groups selected from C 1 -C 6 alkyl, C 1 -C 6 halogenoalkyl, and halogen; (d) Ci-Ce alkoxy which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; or (e) halogen, R 3c and R 3d are hydrogen, R 5 and R 6 are hydrogen, n is 1; or a pharmaceutically acceptable salt thereof; wherein the subject is a human subject.
Current tap element for an energy storage module, comprising: - a contact element made of a first metal for being directly connected to a pole of the energy storage module, - a conducting element that is directly connected to the contact element and made of a second metal that differs from the first metal, characterized in that - the contact element and the conducting element overlap in an overlapping area, - an injection-molded plastic sleeve encases the conducting element, wherein the overlapping area is located completely inside the plastic sleeve, and in that - the conducting element is guided up to the edge of the plastic sleeve, so that it can be contacted, and a connector is positioned in the plastic sleeve for contacting the conducting element, - wherein the first metal consists mostly of aluminum and the second metal consist mostly of copper. - a contact element made of a first metal for being directly connected to a pole of the energy storage module, - a conducting element that is directly connected to the contact element and made of a second metal that differs from the first metal, - the contact element and the conducting element overlap in an overlapping area, - an injection-molded plastic sleeve encases the conducting element, wherein the overlapping area is located completely inside the plastic sleeve, - the conducting element is guided up to the edge of the plastic sleeve, so that it can be contacted, and a connector is positioned in the plastic sleeve for contacting the conducting element, - wherein the first metal consists mostly of aluminum and the second metal consist mostly of copper.
A polymer nanoparticle composite comprising: a block copolymer comprising a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment; and MnCaP that is producible by the reaction of HPO 4 2- with Ca 2+ and Mn 2+.
A method, comprising: sending, by an application, a query to a modem; receiving, by the application, from the modem, information indicative of a radio coverage condition, wherein a user equipment,UE, includes the application and the modem; based on the received information, determining that the UE is in an enhanced coverage state; and in response to the determining, controlling, by the application, uplink data transmission by the modem to reduce power consumption of the UE, wherein controlling uplink data transmission includes refraining from sending uplink data when at least one of the following occurs: the UE is in one of a set of predefined coverage enhancement levels, coverage classes, or coverage enhancement modes, the data repetition indicator is above a predefined repetition threshold, a signal strength at the UE is below a predefined signal strength threshold, or a signal quality at the UE is below a predefined signal quality threshold; a predefined timer associated with the transmission controlling has not expired; a battery level of the UE is lower than a second threshold; or the UE is not plugged into a power outlet. sending, by an application, a query to a modem; receiving, by the application, from the modem, information indicative of a radio coverage condition, wherein a user equipment,UE, includes the application and the modem; based on the received information, determining that the UE is in an enhanced coverage state; and in response to the determining, controlling, by the application, uplink data transmission by the modem to reduce power consumption of the UE, wherein controlling uplink data transmission includes refraining from sending uplink data when at least one of the following occurs: the UE is in one of a set of predefined coverage enhancement levels, coverage classes, or coverage enhancement modes, the data repetition indicator is above a predefined repetition threshold, a signal strength at the UE is below a predefined signal strength threshold, or a signal quality at the UE is below a predefined signal quality threshold; a predefined timer associated with the transmission controlling has not expired; a battery level of the UE is lower than a second threshold; or the UE is not plugged into a power outlet. the UE is in one of a set of predefined coverage enhancement levels, coverage classes, or coverage enhancement modes, the data repetition indicator is above a predefined repetition threshold, a signal strength at the UE is below a predefined signal strength threshold, or a signal quality at the UE is below a predefined signal quality threshold; a predefined timer associated with the transmission controlling has not expired; a battery level of the UE is lower than a second threshold; or the UE is not plugged into a power outlet.
A method of measuring the pH of a solution, wherein the method comprises the steps of: - providing a solution comprising a quinone, a quinone derivative, and/or a pH indicator, wherein the quinone, quinone derivative, and/or pH indicator is dissolved in the solution; - applying the solution to a three-electrode electrochemical cell; - measuring an electrochemical response of the electrochemical cell; and - quantifying the pH of the solution as a function of the electrochemical response of the electrochemical cell, wherein the response correlates with the electrochemical state of the quinone, quinone derivative and/or pH indicator. - providing a solution comprising a quinone, a quinone derivative, and/or a pH indicator, wherein the quinone, quinone derivative, and/or pH indicator is dissolved in the solution; - applying the solution to a three-electrode electrochemical cell; - measuring an electrochemical response of the electrochemical cell; and - quantifying the pH of the solution as a function of the electrochemical response of the electrochemical cell, wherein the response correlates with the electrochemical state of the quinone, quinone derivative and/or pH indicator.
A container cap configured to couple to an access opening of a container, the access opening having a seal configured to cover the access opening, the container cap comprising: a cap body comprising: a cylindrical-shaped side wall having a bottom edge that defines an opening to an interior of said cap body; and a top wall portion integrated with said cylindrical-shaped side wall and at least partially enclosing the interior of said cap body; and a seal opening assembly integrated with said cap body, wherein said seal opening assembly comprises÷ a seal piercing member configured to pierce the seal covering the access opening, characterized in that the seal opening assembly further comprises a slot defined in said top wall portion of said cap body and in that the seal piercing member is formed on a first side of said slot. a cap body comprising: a cylindrical-shaped side wall having a bottom edge that defines an opening to an interior of said cap body; and a top wall portion integrated with said cylindrical-shaped side wall and at least partially enclosing the interior of said cap body; and a cylindrical-shaped side wall having a bottom edge that defines an opening to an interior of said cap body; and a top wall portion integrated with said cylindrical-shaped side wall and at least partially enclosing the interior of said cap body; and a seal opening assembly integrated with said cap body, wherein said seal opening assembly comprises÷ a seal piercing member configured to pierce the seal covering the access opening, characterized in that the seal opening assembly further comprises a slot defined in said top wall portion of said cap body and in that the seal piercing member is formed on a first side of said slot. a seal piercing member configured to pierce the seal covering the access opening, characterized in that the seal opening assembly further comprises a slot defined in said top wall portion of said cap body and in that the seal piercing member is formed on a first side of said slot.
Laser sparkplug for an internal combustion engine comprising at least one means for guiding, shaping and/or generating laser radiation, also comprising a combustion chamber window and a housing, wherein the housing, on the side of the combustion chamber window lying opposite the means, in particular at a combustion-chamber-side end of the housing, has a diaphragm for the laser radiation which is guided, shaped and/or generated by the means to pass through into a combustion chamber, wherein the diaphragm has an end facing the combustion chamber and an end facing away from the combustion chamber, wherein the inner contour of the diaphragm has an extremal cross section (Qs) in a region which is spaced apart both from the end of the diaphragm facing the combustion chamber and from the end of the diaphragm facing away from the combustion chamber, characterized in that the diaphragm has, on a side facing the combustion chamber, at least one outer edge whose contour deviates inwardly with respect to a sharp-edged outer edge.
A system for delivering a pressurized flow of breathable gas to a patient, the system comprising: a patient interface configured to contact a wearer's head, the patient interface comprising a frame, a cushion supported by the frame and configured to sealingly connect the patient interface to the patient's face and form a chamber between the frame and the wearer's face, and an inlet port in the frame to receive the pressurized flow of breathable gas; a flow generator configured to generate the pressurized flow, capable of creating a pressure of about 2-40 cm H 2 O in the chamber; and a flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) to house the flow generator, wherein at least a portion of the flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) is mounted on the frame of the patient interface and an outlet (6n, 30e) of the flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) and the inlet port of the frame are connected by a soft joint to reduce the transmission of vibration and/or noise generated by the flow generator to the patient interface. a patient interface configured to contact a wearer's head, the patient interface comprising a frame, a cushion supported by the frame and configured to sealingly connect the patient interface to the patient's face and form a chamber between the frame and the wearer's face, and an inlet port in the frame to receive the pressurized flow of breathable gas; a flow generator configured to generate the pressurized flow, capable of creating a pressure of about 2-40 cm H 2 O in the chamber; and a flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) to house the flow generator, wherein at least a portion of the flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) is mounted on the frame of the patient interface and an outlet (6n, 30e) of the flow generator housing (6a, 6b, 6f, 6g, 6h, 30, 30a, 30b) and the inlet port of the frame are connected by a soft joint to reduce the transmission of vibration and/or noise generated by the flow generator to the patient interface.
A method for a wireless device operable in a wireless communication system, comprising: downloading a location database into the wireless device, wherein the location database comprises a plurality of transponder identifications, location information and control information, the control information providing commands to control various operating functions of the wireless device based on the location of the wireless device; transmitting a first signal to a transponder, said transponder operating independently of said wireless communication system; receiving a second signal from the transponder, said second signal including identifying data associated with the transponder; and determining a location of the wireless device within an environment or classifying the environment based, at least in part, upon the received identifying data of the second signal, wherein determining the location of the wireless device is accomplished at the wireless device by using the location database, determining an action to perform based on the location of the wireless device by using the location database on the wireless device to access the control information for the transponder; and performing the action at the wireless device in response to the determined location of the wireless device, whereby the action comprises controlling an operating function or switching or changing a profile of the wireless device. downloading a location database into the wireless device, wherein the location database comprises a plurality of transponder identifications, location information and control information, the control information providing commands to control various operating functions of the wireless device based on the location of the wireless device; transmitting a first signal to a transponder, said transponder operating independently of said wireless communication system; receiving a second signal from the transponder, said second signal including identifying data associated with the transponder; and determining a location of the wireless device within an environment or classifying the environment based, at least in part, upon the received identifying data of the second signal, wherein determining the location of the wireless device is accomplished at the wireless device by using the location database, determining an action to perform based on the location of the wireless device by using the location database on the wireless device to access the control information for the transponder; and performing the action at the wireless device in response to the determined location of the wireless device, whereby the action comprises controlling an operating function or switching or changing a profile of the wireless device.
A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomer to form a reactive polymer, and (ii) reacting the reactive polymer with an imine compound containing a heterocyclic group and a hydrocarbyloxy-substituted or silyloxy-substituted aryl group. (i) polymerizing monomer to form a reactive polymer, and (ii) reacting the reactive polymer with an imine compound containing a heterocyclic group and a hydrocarbyloxy-substituted or silyloxy-substituted aryl group.
A process for the dehydrogenation of alkanes, alkenes or alkyl benzenes to the corresponding unsaturated chemical products and hydrogen (H 2), comprising contacting the alkane, alkene or alkyl benzene with a metallic sulfide (MeS) catalyst, wherein - the dehydrogenation is conducted in one or more dehydrogenation reactors in the presence of hydrogen sulfide (H 2 S) without formation of H 2 S as a reaction product, - steam (H 2 O) represents below 10% (vol. flow) of the gas used as carrier gas for the alkanes, alkenes or alkyl benzenes, - the molar ratio of hydrogen sulfide to alkanes, alkenes or alkyl benzene is between 0.01 and 0.2, - the molar ratio of hydrogen sulfide (H 2 S) to hydrogen (H 2) is between 0.01 and 0.2, and - either benzene, toluene or combinations thereof or methane, ethane or combinations thereof are used as carrier gas. - the dehydrogenation is conducted in one or more dehydrogenation reactors in the presence of hydrogen sulfide (H 2 S) without formation of H 2 S as a reaction product, - steam (H 2 O) represents below 10% (vol. flow) of the gas used as carrier gas for the alkanes, alkenes or alkyl benzenes, - the molar ratio of hydrogen sulfide to alkanes, alkenes or alkyl benzene is between 0.01 and 0.2, - the molar ratio of hydrogen sulfide (H 2 S) to hydrogen (H 2) is between 0.01 and 0.2, and - either benzene, toluene or combinations thereof or methane, ethane or combinations thereof are used as carrier gas.
Method of bleaching a pulp, comprising the step of providing a composition for use in bleaching of pulps, the composition comprising (a) one or more particulate alkaline earth metal oxides or alkaline earth metal hydroxides or mixtures thereof; and (b) one or more pitch control additives wherein the content of the said particulate alkaline earth metal oxide or alkaline earth metal hydroxide ranges from 10 wt.-% to 90 wt.-%, and the content of the said pitch control additive ranges from 90 wt.-% to10 wt.-%, each on the basis of the total solids content of the composition; and the step of mixing said composition with the said pulp in such an amount that the said particulate alkaline earth metal oxide or alkaline earth metal hydroxide is present in the said pulp in an amount ranging from 0.1 to 8 wt.-%, and that said pitch control additive is present in the said pulp in an amount ranging from 0.1 to 8 wt.-%, each on the basis of the total solids content of the said pulp during bleaching. (a) one or more particulate alkaline earth metal oxides or alkaline earth metal hydroxides or mixtures thereof; and (b) one or more pitch control additives
Self-cooling high-voltage cable with a low level of field emission, comprising a metallic inner conductor for carrying current and also a metallic outer conductor for carrying current, the said conductors both extending in a running direction, and also comprising at least one electrically insulating spacer which is designed and arranged in such a way that the metallic inner conductor and the metallic outer conductor are spaced apart from one another by the spacer and are held such that they run substantially coaxially in relation to one another, wherein the metallic outer conductor encloses an interior space within which the inner conductor and the spacer are arranged, wherein the spacer comprises an inner bearing part for bearing against the inner conductor, and wherein the spacer comprises an outer bearing part for bearing against the metallic outer conductor, wherein the inner bearing part is designed in such a way that it covers at most 15% of the surface of the inner conductor in the running direction, and wherein the outer bearing part is designed in such a way that it covers at most 50% of the inner surface of the outer conductor, wherein the inner conductor and the outer conductor delimit an intermediate space within which the spacer is arranged, wherein the intermediate space is additionally filled with an insulation medium, wherein the insulation medium is either liquid or is liquefied by the operating temperature which is produced during operation of the high-voltage cable, in order to create natural convection of the insulation medium between the inner conductor and the outer conductor in the intermediate space at operating temperature.
An apparatus for gas cleaning, comprising: - a passage for gas flow; - a hydrophilic carrier permeable for gas flow, at least part of which is positioned within said passage for gas flow and configured for containing a reagent that contacts the gas in said passage for gas flow; - a unit for disposing liquid to said carrier; and - a controller, associated with said unit for disposing, the apparatus being characterized in that the controller is configured for: controlling the unit for disposing to dispose an aqueous solution of dissolved reagent to the carrier; and after that controlling the unit for disposing to dispose liquid in case the humidity of the gas entering said carrier is below a first humidity threshold, or to stop disposing liquid in case the humidity of the gas entering said carrier is above a second humidity threshold. - a passage for gas flow; - a hydrophilic carrier permeable for gas flow, at least part of which is positioned within said passage for gas flow and configured for containing a reagent that contacts the gas in said passage for gas flow; - a unit for disposing liquid to said carrier; and - a controller, associated with said unit for disposing, the apparatus being characterized in that the controller is configured for: controlling the unit for disposing to dispose an aqueous solution of dissolved reagent to the carrier; and after that controlling the unit for disposing to dispose liquid in case the humidity of the gas entering said carrier is below a first humidity threshold, or to stop disposing liquid in case the humidity of the gas entering said carrier is above a second humidity threshold. controlling the unit for disposing to dispose an aqueous solution of dissolved reagent to the carrier; and after that controlling the unit for disposing to dispose liquid in case the humidity of the gas entering said carrier is below a first humidity threshold, or to stop disposing liquid in case the humidity of the gas entering said carrier is above a second humidity threshold.
A method for preparing methyl -3-[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino] phenyl]amino]phenylmethylene)-oxindole-6-carboxylate of formula 1, comprising: reacting methyl -1-acetyl-3-(methoxyphenylmethylene)-oxindole-6-carboxylate of formula 2 with N -(4-aminophenyl)- N,4-dimethyl-1-piperazine acetamide and subsequently reacting with a suitable base in a suitable solvent, characterized in that the reaction is carried out without isolation of the intermediate and the base is selected from an alkali hydroxide, potassium tert-butoxide and sodium ethoxide, and in that the solvent is selected from C1 to C4 aliphatic alcohols, and their mixtures.