A flow cell, comprising: a plurality of inlet ports (120, 122, 124, 126, 128, 130), each inlet port of the plurality of inlet ports sized to receive a flow of reagent from a corresponding reagent of a plurality of reagents into the flow cell; characterized in that an outlet port sized to pass a flow of reagent out of the flow cell; and a flow channel positioned between, and in fluid communication with, each inlet port of the plurality of inlet ports and the outlet port, the flow channel comprising: a manifold section having a plurality of manifold branches in fluid communication with a common line, each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports, and a detection section in fluid communication with the common line and the outlet port, the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times smaller than a swept volume of the detection section, wherein the swept volume is defined as the total internal volume of the flow channel of the flow cell. a plurality of inlet ports (120, 122, 124, 126, 128, 130), each inlet port of the plurality of inlet ports sized to receive a flow of reagent from a corresponding reagent of a plurality of reagents into the flow cell; characterized in that an outlet port sized to pass a flow of reagent out of the flow cell; and a flow channel positioned between, and in fluid communication with, each inlet port of the plurality of inlet ports and the outlet port, the flow channel comprising: a manifold section having a plurality of manifold branches in fluid communication with a common line, each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports, and a detection section in fluid communication with the common line and the outlet port, the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times a manifold section having a plurality of manifold branches in fluid communication with a common line, each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports, and a detection section in fluid communication with the common line and the outlet port, the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times smaller than a swept volume of the detection section, wherein the swept volume is defined as the total internal volume of the flow channel of the flow cell.