A device for producing droplets comprising a flow path comprising: a) one or more sample inlets (0103, 0203, 0303, 0403, 0503, 0603, 0703); b) one or more reagent inlets (0105, 0205, 0305, 0405, 0505, 0605, 0705); c) one or more oil inlets (0101, 0201, 0301, 0401, 0501, 0601, 0701); d) one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); e) a first and a second sample channel (0104, 0204, 0304, 0404, 0504, 0604, 0704), each in fluid communication with the one or more sample inlets (0103, 0203, 0303, 0403, 0503, 0603, 0703); f) a first and a second reagent channel (0106, 0206, 0306, 0406, 0506, 0606, 0706), each in fluid communication with the one or more reagent inlets (0105, 0205, 0305, 0405, 0505, 0605, 0705); g) a first, second, third, and fourth oil channel (0102, 0202, 0302, 0402, 0502, 0602, 0702) in fluid communication with the one or more oil inlets (0101, 0201, 0301, 0401, 0501, 0601, 0701); h) a first intersection at which the first reagent channel and the first sample channel intersect; i) a second intersection at which the second reagent channel and the second sample channel intersect; j) a first and a second droplet channel (0107, 0207, 0307, 0407, 0507, 0607, 0707), wherein the first droplet channel is in fluid communication with the first intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708) and the second droplet channel is in fluid communication with the second intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); k) a third intersection at which the first and second oil channels and the first droplet channel intersect, wherein the third intersection is fluidically disposed between the first intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); and l) a fourth intersection at which the third and fourth oil channels and the second droplet channel intersect, wherein the fourth intersection is fluidically disposed between the second intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708). a) one or more sample inlets (0103, 0203, 0303, 0403, 0503, 0603, 0703); b) one or more reagent inlets (0105, 0205, 0305, 0405, 0505, 0605, 0705); c) one or more oil inlets (0101, 0201, 0301, 0401, 0501, 0601, 0701); d) one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); e) a first and a second sample channel (0104, 0204, 0304, 0404, 0504, 0604, 0704), each in fluid communication with the one or more sample inlets (0103, 0203, 0303, 0403, 0503, 0603, 0703); f) a first and a second reagent channel (0106, 0206, 0306, 0406, 0506, 0606, 0706), each in fluid communication with the one or more reagent inlets (0105, 0205, 0305, 0405, 0505, 0605, 0705); g) a first, second, third, and fourth oil channel (0102, 0202, 0302, 0402, 0502, 0602, 0702) in fluid communication with the one or more oil inlets (0101, 0201, 0301, 0401, 0501, 0601, 0701); h) a first intersection at which the first reagent channel and the first sample channel intersect; i) a second intersection at which the second reagent channel and the second sample channel intersect; j) a first and a second droplet channel (0107, 0207, 0307, 0407, 0507, 0607, 0707), wherein the first droplet channel is in fluid communication with the first intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708) and the second droplet channel is in fluid communication with the second intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); k) a third intersection at which the first and second oil channels and the first droplet channel intersect, wherein the third intersection is fluidically disposed between the first intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708); and l) a fourth intersection at which the third and fourth oil channels and the second droplet channel intersect, wherein the fourth intersection is fluidically disposed between the second intersection and the one or more collection reservoirs (0108, 0208, 0308, 0408, 0508, 0608, 0708).