A patient support system for reducing the formation of bedsores on a patient positioned on an operating room table, the system comprising: a plurality of no-air-loss air cells, wherein at least a portion of the plurality of no-air-loss air cells are configured to engage the operating room table, and wherein at least a portion of the plurality of no-air-loss air cells form a no-air-loss patient support surface, at least one fluid pump in fluid communication with the plurality of air cells, at least one pressure release valve in fluid communication with the plurality of air cells, at least one pressure sensor configured to measure the pressure of a fluid, a computer operatively coupled to the at least one fluid pump, the at least one pressure release valve and the at least one pressure sensor, said computer comprising a system processor, the at least one pressure sensor is configured to measure the fluid pressure within the system and send a signal to the system processor representing the fluid pressure within at least a portion of the air cells, wherein the computer is configured to compare the signal representing the fluid pressure within at least a portion of the patient support system to a desired patient support system air pressure set point and determine whether to activate the at least one fluid pump for supplying air to and the at least one pressure release valve for removing air from the plurality of air cells in order to adjust the fluid pressure within at least a portion of the air cells to within a predetermined tolerance of the desired patient support system air pressure set point, characterised in that once the desired air pressure set point has been achieved with the patient support system in a loaded condition, within a predetermined tolerance, the computer is configured so as to not send a signal to the at least one fluid pump or the at least one pressure release valve or to turn off automatically such that no more adjustments to the air pressure within the patient support system are made. a plurality of no-air-loss air cells, wherein at least a portion of the plurality of no-air-loss air cells are configured to engage the operating room table, and wherein at least a portion of the plurality of no-air-loss air cells form a no-air-loss patient support surface, at least one fluid pump in fluid communication with the plurality of air cells, at least one pressure release valve in fluid communication with the plurality of air cells, at least one pressure sensor configured to measure the pressure of a fluid, a computer operatively coupled to the at least one fluid pump, the at least one pressure release valve and the at least one pressure sensor, said computer comprising a system processor, the at least one pressure sensor is configured to measure the fluid pressure within the system and send a signal to the system processor representing the fluid pressure within at least a portion of the air cells, wherein the computer is configured to compare the signal representing the fluid pressure within at least a portion of the patient support system to a desired patient support system air pressure set point and determine whether to activate the at least one fluid pump for supplying air to and the at least one pressure release valve for removing air from the plurality of air cells in order to adjust the fluid pressure within at least a portion of the air cells to within a predetermined tolerance of the desired patient support system air pressure set point, characterised in that once the desired air pressure set point has been achieved with the patient support system in a loaded condition, within a predetermined tolerance, the computer is configured so as to not send a signal to the at least one fluid pump or the at least one pressure release valve or to turn off automatically such that no more adjustments to the air pressure within the patient support system are made.