mhurhangee/ep-ind-claims huggingface dataset:
A system, comprising: a disinfection environment tracking engine configured to: access patient room data indicative of a state of a patient room of a patient; access medical data of the patient, the medical data of the patient specifying a medical condition of the patient; and access real-time location data of the patient; and an ultra-violet light control engine configured to control operation of a UV light to disinfect the patient room based on the patient room data, the medical data of the patient, and the real-time location data of the patient, wherein the UV light control engine is further configured to control the operation of the UV light by: activating the UV light during the unoccupied time period responsive to a determination from the real-time location data that the patient is more than a threshold distance from the patient room; and deactivating the UV light during the unoccupied time period responsive to a determination from the real-time location data that the patient is less than a threshold distance from the patient room. a disinfection environment tracking engine configured to: access patient room data indicative of a state of a patient room of a patient; access medical data of the patient, the medical data of the patient specifying a medical condition of the patient; and access real-time location data of the patient; and access patient room data indicative of a state of a patient room of a patient; access medical data of the patient, the medical data of the patient specifying a medical condition of the patient; and access real-time location data of the patient; and an ultra-violet light control engine configured to control operation of a UV light to disinfect the patient room based on the patient room data, the medical data of the patient, and the real-time location data of the patient, activating the UV light during the unoccupied time period responsive to a determination from the real-time location data that the patient is more than a threshold distance from the patient room; and deactivating the UV light during the unoccupied time period responsive to a determination from the real-time location data that the patient is less than a threshold distance from the patient room.
An epidermal growth factor receptor (EGFR)-homing vector comprising a double-stranded RNA (dsRNA) molecule with an EGFR-binding peptide or polypeptide, for use in treatment of cancer characterized by EGFR overexpressing cells, wherein said treatment comprises concomitant or sequential administration of immune cells and wherein said immune cells are selected from tumor-infiltrating T-cells (T-TILs), tumor specific engineered T-cells, and peripheral blood mononuclear cells (PBMCs).
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R N is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; A is a 3 membered monocyclic ring; B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl; R 1 is halo, alkyl, OH, alkoxy, thioalkyl, trifluoromethoxy; or two R 1 on adjacent atoms, taken together, form wherein J is selected from the group consisting of CH 2, CF 2, or C(CH 3) 2; W is independently a bond or a (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by, -O-, -S-, -SO 2 -, or-NR'-; R' is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocyclic; R W is independently H, CN, NO 2, N 2, CF 3, OCF 3, OH, OR, CO 2 R, C N 2, -O(C1-C6)alkylidene-OR, -O(C1-C6)alkylidene-N 2, -O(C1-C6)alkylidene-heterocyclic, or an aliphatic, cycloaliphatic, aryl, aryloxy, heterocyclic, or heteroaryl, wherein, when substituted, R w is substituted with up to two R 2; R 2 is halo, CN, NO 2, CF 3, OCF 3, OR, OC R, OC N 2, SR, S R, SO 2 R, SO 2 N 2, SO 3 R, C R, CO 2 R, C N 2, N 2, NRC R, NRCO 2 R, NRC N 2, NRSO 2 R, B 2, or NRSO 2 N 2; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; n is 1 or 2; w is an integer from 0 to 4 inclusive; and x is an integer from 0 to 5 inclusive; provided that when W is a bond and R w is cycloaliphatic, heterocycloaliphatic, aryl, or heteroaryl, -W-R w is attached to the 3- or 4- position of the pyridyl ring. R N is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl; A is a 3 membered monocyclic ring; B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl; R 1 is halo, alkyl, OH, alkoxy, thioalkyl, trifluoromethoxy; or two R 1 on adjacent atoms, taken together, form wherein J is selected from the group consisting of CH 2, CF 2, or C(CH 3) 2; W is independently a bond or a (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by, -O-, -S-, -SO 2 -, or-NR'-; R' is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocyclic; R W is independently H, CN, NO 2, N 2, CF 3, OCF 3, OH, OR, CO 2 R, C N 2, -O(C1-C6)alkylidene-OR, -O(C1-C6)alkylidene-N 2, -O(C1-C6)alkylidene-heterocyclic, or an aliphatic, cycloaliphatic, aryl, aryloxy, heterocyclic, or heteroaryl, wherein, when substituted, R w is substituted with up to two R 2; R 2 is halo, CN, NO 2, CF 3, OCF 3, OR, OC R, OC N 2, SR, S R, SO 2 R, SO 2 N 2, SO 3 R, C R, CO 2 R, C N 2, N 2, NRC R, NRCO 2 R, NRC N 2, NRSO 2 R, B 2, or NRSO 2 N 2; R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl; n is 1 or 2; w is an integer from 0 to 4 inclusive; and x is an integer from 0 to 5 inclusive; provided that when W is a bond and R w is cycloaliphatic, heterocycloaliphatic, aryl, or heteroaryl, -W-R w is attached to the 3- or 4- position of the pyridyl ring.
A dental light-curing apparatus for dental material to be cured, comprising a handpiece and a base station, the handpiece comprising a light source, In particular a plurality of LED chips (42, 44, 46 and 48) which are arranged adjacent to each other with respect to the optical axis, a control device for the light source and at least one sensor, which is arranged adjacent to the light source, wherein - again with respect to the optical axis - a light guide device, in particular a light guide rod, extends in front of the light source, the light guide rod comprising a passband for wavelengths, which passband comprises at least blue visible light, and especially also comprises green visible light and UV light, and having a selection device for control programs of the control device, especially a button on the hand piece, wherein the control device also comprises a control program "pre-curing", which is selectable by the selector device, and in which the curing apparatus can be turned on with a sub-wavelength range different from a main wavelength range of light curing and the light radiation of which is outside the sensitivity range of the dental material to be cured, characterized in that the control device automatically turns on the light source in the main wavelength range for pre-curing excess adhesive in dental restorations, especially in adhesive crowns or adhesive bridges, if at least one sensor detects the light reflected from a tooth surface In the sub-wavelength range.
A method for enhancing fire-suppression for a class E cargo aircraft, comprising: receiving a fire-warning signal indicating presence of fire in a cargo compartment onboard a class E cargo aircraft at a first altitude (task 602); distributing an initial fire-suppression agent in the cargo compartment at the first altitude sufficient to suppress fire for an initial fire-suppression time interval during a depressurization phase during which the class E cargo aircraft flies to a second altitude below the first altitude (task 604) and during which airflow to the cargo compartment is shut off; distributing a re-enforcing fire-suppression agent in the cargo compartment (task 618) during a re-pressurization phase when a cabin altitude is below a predetermined cabin pressure level during which the class E cargo aircraft flies from the second altitude to a landing (task 616), after the initial fire-suppression time interval elapses; and maintaining distribution of the re-enforcing fire-suppression agent during a re-enforcing fire-suppression time interval. receiving a fire-warning signal indicating presence of fire in a cargo compartment onboard a class E cargo aircraft at a first altitude (task 602); distributing an initial fire-suppression agent in the cargo compartment at the first altitude sufficient to suppress fire for an initial fire-suppression time interval during a depressurization phase during which the class E cargo aircraft flies to a second altitude below the first altitude (task 604) and during which airflow to the cargo compartment is shut off; distributing a re-enforcing fire-suppression agent in the cargo compartment (task 618) during a re-pressurization phase when a cabin altitude is below a predetermined cabin pressure level during which the class E cargo aircraft flies from the second altitude to a landing (task 616), after the initial fire-suppression time interval elapses; and maintaining distribution of the re-enforcing fire-suppression agent during a re-enforcing fire-suppression time interval.
Method for monitoring the integrity of reference stations (1.1, 1.2, 1.3,..., 1.n), having known and fixed coordinates, of a correction service system for a satellite-assisted navigation system in a coordinate system, wherein at least one first group of the reference stations (1.1, 1.2, 1.3, 1,..., 1.n) is operated in order to receive satellite signals from a plurality of satellites of the signal-assisted navigation system, wherein a) a first reference station (1.2, 3) is selected from the first group, b) at least one first correction value is determined in accordance with the satellite signals respectively received by the other reference stations (1.1, 1.3,..., 1.n) of the first group and the known coordinates of the respective other reference station (1.1, 1.3,..., 1.n) of the first group, and wherein c) the monitoring of the integrity is carried out by comparing first coordinates of the first reference station (1.2, 3), which are determined by means of satellite signals received by the first reference station (1.2, 3) and the at least one first correction value, with the known coordinates of the first reference station (1.2, 3), and checking them for at least one first deviation, characterized in that in a step f) a second reference station (1.3, 3'), which is different from the first reference station (1.2, 3) is selected from the first group, and in that if a critical first deviation is not determined, the steps b) and c) are carried out for the second reference station (1.3, 3'), or in that in a step f') the second reference station (1.3, 3') is selected from the first group, and in that when a critical first deviation is determined the steps b) and c) are carried out for the second reference station (1.3, 3') instead of the first reference station (1.2, 3), without taking into account the first reference station (1.2, 3). a) a first reference station (1.2, 3) is selected from the first group, b) at least one first correction value is determined in accordance with the satellite signals respectively received by the other reference stations (1.1, 1.3,..., 1.n) of the first group and the known coordinates of the respective other reference station (1.1, 1.3,..., 1.n) of the first group, and wherein c) the monitoring of the integrity is carried out by comparing first coordinates of the first reference station (1.2, 3), which are determined by means of satellite signals received by the first reference station (1.2, 3) and the at least one first correction value, with the known coordinates of the first reference station (1.2, 3), and checking them for at least one first deviation,
Apparatus for manufacturing tyres, having a tyre building drum with a device for realizing a ply turn-up for manufacturing unvulcanized green tyres, in which the ply turn-up can be realized by a plurality of turn-up fingers, which are coupled to a drive unit which is arranged outside the tyre building drum, characterized in that the external drive of the turn-up fingers is realized by a number of separately driven spindles, which are mounted in a fixed tyre building ring and can be driven synchronously in opposite directions.
A polymer particle, formed from reacting a solution including: at least one monomer; at least one crosslinker selected from or and at least one polymerizable pharmaceutical agent, wherein the at least one pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage. at least one monomer; at least one crosslinker selected from or and at least one polymerizable pharmaceutical agent, wherein the at least one pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage.
A coaxial network communication node to receive multimedia content from one or more other communication nodes in a coaxial network, the communication node characterized by being configured to: determine a delay-spread of a coaxial channel based on receipt of a probe from a transmitting node; configure a channel-shortening time-domain equalizer, TEQ, filter to effectively shorten the channel based on the delay spread; and instruct the transmitting node to shorten a length of a cyclic prefix based on the delay spread for subsequent packet-based transmissions to be received from the transmitting node over the coaxial channel; wherein prior to configuring the channel-shortening TEQ filter to effectively shorten the channel, the communication node is configured to store the probe and configure the channel-shortening TEQ filter to reuse the stored probe until the channel-shortening TEQ filter converges to obtain filter coefficients for configuring the channel-shortening TEQ filter to effectively shorten the channel. determine a delay-spread of a coaxial channel based on receipt of a probe from a transmitting node; configure a channel-shortening time-domain equalizer, TEQ, filter to effectively shorten the channel based on the delay spread; and instruct the transmitting node to shorten a length of a cyclic prefix based on the delay spread for subsequent packet-based transmissions to be received from the transmitting node over the coaxial channel; wherein prior to configuring the channel-shortening TEQ filter to effectively shorten the channel, the communication node is configured to store the probe and configure the channel-shortening TEQ filter to reuse the stored probe until the channel-shortening TEQ filter converges to obtain filter coefficients for configuring the channel-shortening TEQ filter to effectively shorten the channel.
An axle assembly (14, 110) for a vehicle, comprising: an axle (16, 116) having opposite axle ends (18, 118); and a pair of axle hubs (20, 120); characterized by: a pair of double kingpin hinge arrangements (22, 114), each said double kingpin hinge arrangement (22, 114) including a first pivot pin (32, 122) connected with a respective one of said axle ends (18, 118), a second pivot pin (34, 124) operatively associated with a respective said axle hub (20, 120), and a knuckle (28, 126) interconnecting said first pivot pin (32, 122) and said second pivot pin (34, 124); and at least one steering cylinder (64, 66, 72, 82, 84, 92, 94, 102, 104) associated with each said double kingpin hinge arrangement (22, 114), each said steering cylinder (64, 66, 72, 82, 84, 92, 94, 102, 104) being interconnected between said axle (16, 116) and said knuckle (28, 126) or said axle hub (20, 120). an axle (16, 116) having opposite axle ends (18, 118); and a pair of axle hubs (20, 120); a pair of double kingpin hinge arrangements (22, 114), each said double kingpin hinge arrangement (22, 114) including a first pivot pin (32, 122) connected with a respective one of said axle ends (18, 118), a second pivot pin (34, 124) operatively associated with a respective said axle hub (20, 120), and a knuckle (28, 126) interconnecting said first pivot pin (32, 122) and said second pivot pin (34, 124); and at least one steering cylinder (64, 66, 72, 82, 84, 92, 94, 102, 104) associated with each said double kingpin hinge arrangement (22, 114), each said steering cylinder (64, 66, 72, 82, 84, 92, 94, 102, 104) being interconnected between said axle (16, 116) and said knuckle (28, 126) or said axle hub (20, 120).
A pharmaceutical composition comprising a therapeutically effective amount of a polypeptide selected from the group of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12 and SEQ ID NO:14, and a pharmaceutically acceptable carrier.
A method of safe flushing of pipes of water supply network, whereby water is drained from at least one selected pipe section to flush out unwanted contents in the pipework wherein the method comprises the following process steps: a) for the selected pipe section of the water supply network, the permissible limits of water pressure in the pipe are read according to the actual or assumed technical specification, and the flushing plan is read with a curve of the planned flow of discharged water from the moment of the start of flushing to the moment of the end of flushing, b) the instantaneous pressure in the pipe of the selected pipe section is measured before the water discharge begins, c) the flushing plan is updated according to the measured instantaneous value of the water pressure in the pipe and the permissible water pressure limits, d) the discharge of water is initiated, with the discharge flow measured and regulated for compliance with the flushing plan, and the continuous measurement of water pressure in the pipeline shall be initiated simultaneously, e) during flushing, the instantaneous water pressure in the pipeline is continuously compared with the permissible pressure limits until the end of the flushing, and if a trend of change in instantaneous pressure values outside the set limits is detected, the flow of discharged water outside the flushing plan is regulated to protect the pipeline from damage by exceeding the set limits. a) for the selected pipe section of the water supply network, the permissible limits of water pressure in the pipe are read according to the actual or assumed technical specification, and the flushing plan is read with a curve of the planned flow of discharged water from the moment of the start of flushing to the moment of the end of flushing, b) the instantaneous pressure in the pipe of the selected pipe section is measured before the water discharge begins, c) the flushing plan is updated according to the measured instantaneous value of the water pressure in the pipe and the permissible water pressure limits, d) the discharge of water is initiated, with the discharge flow measured and regulated for compliance with the flushing plan, and the continuous measurement of water pressure in the pipeline shall be initiated simultaneously, e) during flushing, the instantaneous water pressure in the pipeline is continuously compared with the permissible pressure limits until the end of the flushing, and if a trend of change in instantaneous pressure values outside the set limits is detected, the flow of discharged water outside the flushing plan is regulated to protect the pipeline from damage by exceeding the set limits.
A method, implemented at a computer system that includes one or more processors and system memory, of quantifying a nucleic acid sample comprising nucleic acid of two or more contributors, the method comprising: (a) extracting nucleic acid molecules from the nucleic acid sample; (b) amplifying the extracted nucleic acid molecules; (c) sequencing the amplified nucleic acid molecules using a nucleic acid sequencer to produce nucleic acid sequence reads; (d) mapping, by the one or more processors, the nucleic acid sequence reads to one or more polymorphism loci on a reference sequence; (e) determining, using the mapped nucleic acid sequence reads and by the one or more processors, allele counts of nucleic acid sequence reads for one or more alleles at the one or more polymorphism loci; and (f) quantifying, using a probabilistic mixture model and by the one or more processors, one or more fractions of nucleic acid of the two or more contributors in the nucleic acid sample, wherein using the probabilistic mixture model comprises applying a probabilistic mixture model to the allele counts of nucleic acid sequence reads, and wherein the probabilistic mixture model uses probability distributions to model the allele counts of nucleic acid sequence reads at the one or more polymorphism loci, the probability distributions accounting for errors in the nucleic acid sequence reads, wherein the two or more contributors comprise one or more donors of a transplant and a donee of the transplant, and wherein the nucleic acid sample comprises a sample obtained from the donee. (a) extracting nucleic acid molecules from the nucleic acid sample; (b) amplifying the extracted nucleic acid molecules; (c) sequencing the amplified nucleic acid molecules using a nucleic acid sequencer to produce nucleic acid sequence reads; (d) mapping, by the one or more processors, the nucleic acid sequence reads to one or more polymorphism loci on a reference sequence; (e) determining, using the mapped nucleic acid sequence reads and by the one or more processors, allele counts of nucleic acid sequence reads for one or more alleles at the one or more polymorphism loci; and (f) quantifying, using a probabilistic mixture model and by the one or more processors, one or more fractions of nucleic acid of the two or more contributors in the nucleic acid sample, wherein using the probabilistic mixture model comprises applying a probabilistic mixture model to the allele counts of nucleic acid sequence reads, and wherein the probabilistic mixture model uses probability distributions to model the allele counts of nucleic acid sequence reads at the one or more polymorphism loci, the probability distributions accounting for errors in the nucleic acid sequence reads,
Method for the thermal regeneration of a catalyst for the denitrification of fumes, in which • a regeneration fluid for the catalyst is provided, which has a temperature that is both higher than that of the fumes to be denitrified and ranges between 220°C and 450°C, • upstream of the catalyst the region for supplying the catalyst with fumes to be denitrified is divided into several parts, each of which in cross-section to the flux of the fumes has a section other than zero amounting to between 0.3 and 5 m 2 at the level of the catalyst, and • while the catalyst is being supplied with fumes to be denitrified via all the parts of the supply region, the different parts are successively supplied one by one with the regeneration fluid so that at least 80% of the quantity of regeneration fluid reaches the portion of the catalyst associated with the part being supplied with regeneration fluid, bringing the temperature at the level of the entry surface of this portion of the catalyst to at least 220°C, preferably at least 250°C. • a regeneration fluid for the catalyst is provided, which has a temperature that is both higher than that of the fumes to be denitrified and ranges between 220°C and 450°C, • upstream of the catalyst the region for supplying the catalyst with fumes to be denitrified is divided into several parts, each of which in cross-section to the flux of the fumes has a section other than zero amounting to between 0.3 and 5 m 2 at the level of the catalyst, and • while the catalyst is being supplied with fumes to be denitrified via all the parts of the supply region, the different parts are successively supplied one by one with the regeneration fluid so that at least 80% of the quantity of regeneration fluid reaches the portion of the catalyst associated with the part being supplied with regeneration fluid, bringing the temperature at the level of the entry surface of this portion of the catalyst to at least 220°C, preferably at least 250°C.