mhurhangee/ep-ind-claims huggingface dataset:
A method for computing a stable binding structure between a target molecule and a drug candidate molecule having a heterocycle using a computer, the method comprising: arranging, when constructing a three-dimensional structure of the target molecule and a three-dimensional structure of the drug candidate molecule in a three-dimensional coordinate space by using three-dimensional structure data of the target molecule and three-dimensional structure data of the drug candidate molecule, the target molecule and the drug candidate molecule at a binding site of the target molecule; determining, as a point A1, a point using an area which is a depression in the binding site of the target molecule and where the heterocycle of the drug candidate molecule exists on a surface of the binding site of the target molecule, wherein the point A1 is a center of gravity of the area; determining, as a point A2, a center of gravity of the heterocycle; determining, as a point A3, a point which is a center of gravity of the binding site of the target molecule and is different from A1; determining, as a point A4, a point which is a coordinate of an arbitrary heavy atom of the drug candidate molecule and is different from the A2; determining, as a collective variable, a dihedral angle formed by a plane X formed by the points A1, A2, and A3 and a plane Y formed by the points A1, A2, and A4; and searching for the stable binding structure between the target molecule and the drug candidate molecule by using the collective variable using metadynamics, wherein vectors A1A2 and A2A3 are linearly independent of vector A2A4. arranging, when constructing a three-dimensional structure of the target molecule and a three-dimensional structure of the drug candidate molecule in a three-dimensional coordinate space by using three-dimensional structure data of the target molecule and three-dimensional structure data of the drug candidate molecule, the target molecule and the drug candidate molecule at a binding site of the target molecule; determining, as a point A1, a point using an area which is a depression in the binding site of the target molecule and where the heterocycle of the drug candidate molecule exists on a surface of the binding site of the target molecule, wherein the point A1 is a center of gravity of the area; determining, as a point A2, a center of gravity of the heterocycle; determining, as a point A3, a point which is a center of gravity of the binding site of the target molecule and is different from A1; determining, as a point A4, a point which is a coordinate of an arbitrary heavy atom of the drug candidate molecule and is different from the A2; determining, as a collective variable, a dihedral angle formed by a plane X formed by the points A1, A2, and A3 and a plane Y formed by the points A1, A2, and A4; and searching for the stable binding structure between the target molecule and the drug candidate molecule by using the collective variable using metadynamics, wherein vectors A1A2 and A2A3 are linearly independent of vector A2A4.
A canister and filter assembly for a vacuum cleaner, the assembly comprising: a canister having an inlet port, an outlet port, a flow path between the inlet port and the outlet port, and a peripheral side wall, the peripheral side wall at least partially defining an interior space of the canister; and a filter disposed in the flow path in the interior space of the canister and adjacent the outlet port, the filter including a filter media having a non-pleated portion, a pleated portion, an exterior surface, and an interior surface; wherein the peripheral side wall forms a corner and the filter media defines a corner that is shaped to fit adjacent to the corner of the peripheral side wall; and wherein the non-pleated portion of the exterior surface of the filter media faces the side wall, and the pleated portion of the exterior surface of the filter media faces the interior space of the canister. a canister having an inlet port, an outlet port, a flow path between the inlet port and the outlet port, and a peripheral side wall, the peripheral side wall at least partially defining an interior space of the canister; and a filter disposed in the flow path in the interior space of the canister and adjacent the outlet port, the filter including a filter media having a non-pleated portion, a pleated portion, an exterior surface, and an interior surface; wherein the peripheral side wall forms a corner and the filter media defines a corner that is shaped to fit adjacent to the corner of the peripheral side wall; and wherein the non-pleated portion of the exterior surface of the filter media faces the side wall, and the pleated portion of the exterior surface of the filter media faces the interior space of the canister.
A three-dimensional, 3D, memory device, comprising: a substrate; a peripheral circuit above the substrate; a memory stack comprising interleaved conductive layers and dielectric layers above the peripheral circuit; a P-type doped semiconductor layer above the memory stack; an N-well in the P-type doped semiconductor layer; a plurality of channel structures each extending vertically through the memory stack into the P-type doped semiconductor layer; each channel structure comprising a semiconductor channel; a conductive layer in contact with upper ends of the plurality of channel structures, wherein at least part of the conductive layer is on the P-type doped semiconductor layer; a first source contact above the memory stack and in contact with the P-type doped semiconductor layer; and a second source contact above the memory stack and in contact with the N-well; while semiconductor channel extends above the bottom surface of P-type doped semiconductor layer. a substrate; a peripheral circuit above the substrate; a memory stack comprising interleaved conductive layers and dielectric layers above the peripheral circuit; a P-type doped semiconductor layer above the memory stack; an N-well in the P-type doped semiconductor layer; a plurality of channel structures each extending vertically through the memory stack into the P-type doped semiconductor layer; each channel structure comprising a semiconductor channel; a conductive layer in contact with upper ends of the plurality of channel structures, wherein at least part of the conductive layer is on the P-type doped semiconductor layer; a first source contact above the memory stack and in contact with the P-type doped semiconductor layer; and a second source contact above the memory stack and in contact with the N-well; while semiconductor channel extends above the bottom surface of P-type doped semiconductor layer.
A method for distributing file requests of multimedia content to be delivered in adaptive streaming, comprising: - receiving file requests from at least a client and performing a distribution of the received file requests to deliver the requested file of multimedia content to the client by a delivery application according to the distribution, characterised in that the step of distribution of the received file requests is performed before the file requests are received by the delivery application and comprises: - filtering a group of requests from the received file requests in a determined time interval based on at least one smoothing parameter which is selected from: an estimated size of the requested file, a maximum burst tolerated in a period of time, a maximum available network interface bandwidth to deliver the requested file, a maximum delay tolerated for smoothing the requested file and a range of IP addresses of the client; - applying a delay, which is constant or bitrate-dependent, to the filtered group of requests, to distribute said filtered group of requests over time; and the method further comprising repeating the step of distribution every determined time interval. - receiving file requests from at least a client and performing a distribution of the received file requests to deliver the requested file of multimedia content to the client by a delivery application according to the distribution, characterised in that the step of distribution of the received file requests is performed before the file requests are received by the delivery application and comprises: - filtering a group of requests from the received file requests in a determined time interval based on at least one smoothing parameter which is selected from: an estimated size of the requested file, a maximum burst tolerated in a period of time, a maximum available network interface bandwidth to deliver the requested file, a maximum delay tolerated for smoothing the requested file and a range of IP addresses of the client; - applying a delay, which is constant or bitrate-dependent, to the filtered group of requests, to distribute said filtered group of requests over time; - filtering a group of requests from the received file requests in a determined time interval based on at least one smoothing parameter which is selected from: an estimated size of the requested file, a maximum burst tolerated in a period of time, a maximum available network interface bandwidth to deliver the requested file, a maximum delay tolerated for smoothing the requested file and a range of IP addresses of the client; - applying a delay, which is constant or bitrate-dependent, to the filtered group of requests, to distribute said filtered group of requests over time;
A wound treatment system for treating a tissue site, the system comprising: a distribution manifold including a plurality of flow channels to facilitate the distribution of reduced pressure or fluids to or from the tissue site; a reduced pressure source fluidly connected to the distribution manifold to deliver reduced pressure to the tissue site; an ultrasonic energy transducer positioned adjacent to the distribution manifold; and a drape placed adjacent to the distribution manifold to cover the distribution manifold and the ultrasonic energy transducer. a distribution manifold including a plurality of flow channels to facilitate the distribution of reduced pressure or fluids to or from the tissue site; a reduced pressure source fluidly connected to the distribution manifold to deliver reduced pressure to the tissue site; an ultrasonic energy transducer positioned adjacent to the distribution manifold; and a drape placed adjacent to the distribution manifold to cover the distribution manifold and the ultrasonic energy transducer.
A wireless communications system comprising: a near field communication reference device configured to store object reference data for at least one object associated with a geographic location of said reference NFC device; and a mobile wireless communications device comprising an NFC transceiver configured to communicate with said NFC reference device based upon proximity thereto, an image sensor, a display, and a controller cooperating with said NFC transceiver, said image sensor, and said display and configured to determine a sensed image from said image sensor, select object reference data for the sensed image based upon communication with said NFC reference device, and display the object reference data and said sensed image on said display. a near field communication reference device configured to store object reference data for at least one object associated with a geographic location of said reference NFC device; and a mobile wireless communications device comprising an NFC transceiver configured to communicate with said NFC reference device based upon proximity thereto, an image sensor, a display, and a controller cooperating with said NFC transceiver, said image sensor, and said display and configured to determine a sensed image from said image sensor, select object reference data for the sensed image based upon communication with said NFC reference device, and display the object reference data and said sensed image on said display. an NFC transceiver configured to communicate with said NFC reference device based upon proximity thereto, an image sensor, a display, and a controller cooperating with said NFC transceiver, said image sensor, and said display and configured to determine a sensed image from said image sensor, select object reference data for the sensed image based upon communication with said NFC reference device, and display the object reference data and said sensed image on said display. determine a sensed image from said image sensor, select object reference data for the sensed image based upon communication with said NFC reference device, and display the object reference data and said sensed image on said display.
Homogenizing valve comprising two or more pressurized, movable valve cones, two or more valve seats, and a valve housing surrounding the valve cones and the valve seats, wherein the said valve cones and the said valve seats are arranged such that between them is formed a constriction, constituting two or more homogenization gaps, and wherein the valve cones are screwed on a threaded rod arranged centrally in the valve housing, and wherein the valve cones are arranged such that they are adjusted together with the threaded rod, characterized in that between each and every valve seat and valve cone is formed a radially arranged homogenization gap and an axially arranged homogenization gap.
A method of fabricating a free-standing cathode electrode film for use in an energy storage device, comprising: combining a first portion of an activated carbon material, and at least one component of a composite binder material to form a first mixture, wherein the at least one component comprises at least one of polyvinylidene fluoride (PVDF), a PVDF co-polymer, and poly(ethylene oxide); subjecting the first mixture comprising the first portion of the activated carbon material and the at least one component of the composite binder material to a high shear process; combining a first portion of an active material selected from a lithium metal oxide, a lithium sulfide or a combination thereof, with a second portion of an activated carbon material and a conductive carbon additive to form a second mixture; combining the second mixture with the first mixture after the subjecting step; adding polytetrafluoroethylene (PTFE) to the second mixture to form a third mixture; and calendering the third electrode film mixture to form the free-standing cathode electrode film; wherein the method is a dry fabrication process in which no solvents are used. combining a first portion of an activated carbon material, and at least one component of a composite binder material to form a first mixture, wherein the at least one component comprises at least one of polyvinylidene fluoride (PVDF), a PVDF co-polymer, and poly(ethylene oxide); subjecting the first mixture comprising the first portion of the activated carbon material and the at least one component of the composite binder material to a high shear process; combining a first portion of an active material selected from a lithium metal oxide, a lithium sulfide or a combination thereof, with a second portion of an activated carbon material and a conductive carbon additive to form a second mixture; combining the second mixture with the first mixture after the subjecting step; adding polytetrafluoroethylene (PTFE) to the second mixture to form a third mixture; and calendering the third electrode film mixture to form the free-standing cathode electrode film; wherein the method is a dry fabrication process in which no solvents are used.
A method for aligning film sheets and rectangular panels in a continuous manufacturing system of display panels, the manufacturing system being configured for providing film sheets each formed in a strip shaped film laminate between two longitudinally adjacent, transversely extending slit lines, one being at an upstream side and the other at a downstream side as seen in a feed direction of the film laminate, and conveying the film sheets as an integral unit with the strip shaped film laminate, with respect to a plurality of sequentially conveyed rectangular panels, to a lamination position for lamination with the rectangular panels, peeling the film sheets from the strip shaped film laminate, and laminating the peeled sheets with the rectangular panels conveyed to the lamination position in synchronization with the film sheets to thereby produce display panels in a continuous manner; the method comprising steps of; angularly adjusting the rectangular panel conveyed to the lamination position such that the center line extending in the feeding direction of the rectangular panels is in parallel with the center line extending in the feeding direction of the film sheets conveyed to the lamination position; and positionally adjusting the angularly adjusted rectangular panels by shifting each of the panels by a distance corresponding to a displacement of each panel from the position of the corresponding film sheet conveyed to the lamination position.
An article of footwear comprising: an upper having a forefoot region with a foremost extent; a sole structure having a forefoot portion underlying the forefoot region of the upper, and an extension portion extending forward from the forefoot portion; wherein: the sole structure includes a bladder having a fluid-filled chamber disposed at least partially in the extension portion; the extension portion extends forward of the foremost extent of the upper from a forward edge of the forefoot portion to a distal end, and a top side of the extension portion is spaced apart from the upper between the forward edge of the forefoot portion and the distal end; and the extension portion establishes a propulsion surface beyond the foremost extent of the upper during a forward stride. an upper having a forefoot region with a foremost extent; a sole structure having a forefoot portion underlying the forefoot region of the upper, and an extension portion extending forward from the forefoot portion; wherein: the sole structure includes a bladder having a fluid-filled chamber disposed at least partially in the extension portion; the extension portion extends forward of the foremost extent of the upper from a forward edge of the forefoot portion to a distal end, and a top side of the extension portion is spaced apart from the upper between the forward edge of the forefoot portion and the distal end; and the extension portion establishes a propulsion surface beyond the foremost extent of the upper during a forward stride. the sole structure includes a bladder having a fluid-filled chamber disposed at least partially in the extension portion; the extension portion extends forward of the foremost extent of the upper from a forward edge of the forefoot portion to a distal end, and a top side of the extension portion is spaced apart from the upper between the forward edge of the forefoot portion and the distal end; and the extension portion establishes a propulsion surface beyond the foremost extent of the upper during a forward stride.
An assembly comprising: a rivet defining a rivet head attached to a rivet shank; a washer defining a washer hole; and an insert defining an insert ear configured to cover a surface of a brake disc when the insert positions over a torque face of a slot on a perimeter of the brake disc; wherein the insert ear defines a rivet slot extending through the insert ear, wherein the rivet slot is configured to allow passage of the rivet shank through the rivet slot and into the brake disc to secure the insert to the brake disc, wherein the washer is configured to be positioned between the rivet head and the insert ear when the rivet shank passes through the rivet slot and the washer hole and into the brake disc, and wherein the rivet slot is configured to allow motion of the insert relative to the rivet in a tangential direction (T1, T2) of the brake disc when the rivet shank passes through the rivet slot and the washer hole and into the brake disc. a rivet defining a rivet head attached to a rivet shank; a washer defining a washer hole; and an insert defining an insert ear configured to cover a surface of a brake disc when the insert positions over a torque face of a slot on a perimeter of the brake disc; wherein the insert ear defines a rivet slot extending through the insert ear, wherein the rivet slot is configured to allow passage of the rivet shank through the rivet slot and into the brake disc to secure the insert to the brake disc, wherein the washer is configured to be positioned between the rivet head and the insert ear when the rivet shank passes through the rivet slot and the washer hole and into the brake disc, and wherein the rivet slot is configured to allow motion of the insert relative to the rivet in a tangential direction (T1, T2) of the brake disc when the rivet shank passes through the rivet slot and the washer hole and into the brake disc.
A light emitting device comprising: - a first light emitting portion for emitting daylight with a high color temperature of 6000K or more; and - a second light emitting portion for emitting warm white light at a color temperature of 3000K or less, - a controller for controlling voltage applied to at least any one of the first light emitting portion and the second light emitting portion, wherein each of the first and second light emitting portions comprises a light emitting diode chip and a plurality of phosphors, and the first and second light emitting portions are driven independently, and wherein the phosphors have the following general formula a(M 1 O)·e(M 3 O)·g(M O 5 O P)·h(M X 6 O Y), wherein 0<a≤2, 0<e≤4, 0≤g≤8, 1≤o≤2, 1≤p≤5, 0<h≤2, 1≤x≤2, 1≤y≤5 and M 1 = Cu; M 3 = Mg, Ca, Sr, Ba, Mn; M 5 = Si, Ge, Zr, Mn; M 6 = Eu, and wherein the controller controls the voltage input from the outside with respect to time and applies the voltage to at least any one of the first light emitting portion and the second light emitting portion, and wherein the controller increases and decreases voltage with a 24 hour cycle and applies the voltage to at least any one of the first light emitting portion and the second light emitting portion. - a first light emitting portion for emitting daylight with a high color temperature of 6000K or more; and - a second light emitting portion for emitting warm white light at a color temperature of 3000K or less, - a controller for controlling voltage applied to at least any one of the first light emitting portion and the second light emitting portion,
An iridescent pigment wherein multilayer coats having at least two or more layers of metal oxides comprising one or more metals selected from the group consisting of Ce, Sn, Ti, Fe, Zn and Zr is coated onto the surface of thin platelet-like substrates, wherein the lowest layer of the multilayer coats is a metal oxide layer comprising metals selected from the group consisting of Ce, Sn and Fe and wherein said multilayer coats comprises one or more multilayer units made from a metal oxide layer comprising Sn and attached to the upper face thereof a metal oxide layer comprising Ti, wherein the two layers are coated in the order of SnO 2 as the lowest layer followed by TiO 2, and wherein the multilayer unit made from these two layers (SnO 2 -TiO 2) is repeated one or more times.