A therapeutic treatment system, comprising: a first laser oscillator configured to emit optical radiation in a first wavelength range of 850 nm to 900 nm; a second laser oscillator configured to emit optical radiation in a second wavelength range of 905 nm to 945 nm; a laser light delivery assembly, comprising: a diffuser tip; and an elongated flexible optical fiber adapted to deliver dual wavelength radiation from the first and second laser oscillators to the diffuser tip, wherein the diffuser tip is configured to illuminate an application region of a subject a controller connected to the first and second laser oscillators for controlling the dosage of the dual wavelength radiation transmitted through the application region, a receptacle arranged to receive the delivery assembly and position the delivery assembly at a predetermined distance from the application region, wherein the delivery assembly is configured to deliver a therapeutic treatment to a target site in the application region, wherein the receptacle comprises: a connecting mechanism for interlocking the receptacle and delivery assembly to position the delivery assembly at the predetermined distance; a treatment delivery surface comprising a positioning region for positioning the receptacle relative to the target site in the application region, wherein the positioning region is transparent to the dual wavelength radiation and the remainder of the treatment delivery surface is opaque to the dual wavelength radiation; and a fixing mechanism arranged to secure the receptacle to the application region; wherein the therapeutic treatment comprises administering the dual wavelength radiation for a treatment duration (seconds) that is calculated as energy density (J/cm 2) divided by output power density (W/cm 2), wherein the treatment duration is 100-700 seconds, wherein the energy density is 200-700 J/cm 2, and wherein the output power density is 0.25-5W/cm 2 and is calculated as laser output power divided by beam area. a first laser oscillator configured to emit optical radiation in a first wavelength range of 850 nm to 900 nm; a second laser oscillator configured to emit optical radiation in a second wavelength range of 905 nm to 945 nm; a laser light delivery assembly, comprising: a diffuser tip; and an elongated flexible optical fiber adapted to deliver dual wavelength radiation from the first and second laser oscillators to the diffuser tip, wherein the diffuser tip is configured to illuminate an application region of a subject a diffuser tip; and an elongated flexible optical fiber adapted to deliver dual wavelength radiation from the first and second laser oscillators to the diffuser tip, wherein the diffuser tip is configured to illuminate an application region of a subject a controller connected to the first and second laser oscillators for controlling the dosage of the dual wavelength radiation transmitted through the application region, a receptacle arranged to receive the delivery assembly and position the delivery assembly at a predetermined distance from the application region, wherein the delivery assembly is configured to deliver a therapeutic treatment to a target site in the application region, wherein the receptacle comprises: a connecting mechanism for interlocking the receptacle and delivery assembly to position the delivery assembly at the predetermined distance; a treatment delivery surface comprising a positioning region for positioning the receptacle relative to the target site in the application region, wherein the positioning region is transparent to the dual wavelength radiation and the remainder of the treatment delivery surface is opaque to the dual wavelength radiation; and a fixing mechanism arranged to secure the receptacle to the application region; a connecting mechanism for interlocking the receptacle and delivery assembly to position the delivery assembly at the predetermined distance; a treatment delivery surface comprising a positioning region for positioning the receptacle relative to the target site in the application region, wherein the positioning region is transparent to the dual wavelength radiation and the remainder of the treatment delivery surface is opaque to the dual wavelength radiation; and a fixing mechanism arranged to secure the receptacle to the application region; wherein the therapeutic treatment comprises administering the dual wavelength radiation for a treatment duration (seconds) that is calculated as energy density (J/cm 2) divided by output power density (W/cm 2), wherein the treatment duration is 100-700 seconds, wherein the energy density is 200-700 J/cm 2, and wherein the output power density is 0.25-5W/cm 2 and is calculated as laser output power divided by beam area.