mhurhangee/ep-ind-claims huggingface dataset:
Factor XII inhibitor for use in the prevention and/or the treatment and/or the amelioration of a neurological inflammatory disease, wherein the FXII inhibitor comprises (i) the wild type infestin-4 polypeptide sequence (SEQ ID NO: 2), or a variant thereof, wherein the variant comprises (a) the N-terminal amino acids 2-13 of SEQ ID NO: 2; and at least one and up to five amino acid mutations outside said N-terminal amino acids that result in differences from the wild type infestin-4 sequence; and/or (b) six conserved cysteine residues; and homology of at least 70% to the wild type Infestin-4 sequence; or (ii) an anti-FXII antibody or antigen binding fragment thereof, wherein the antibody binds to FXII and inhibits its activity and/or activation. (i) the wild type infestin-4 polypeptide sequence (SEQ ID NO: 2), or a variant thereof, wherein the variant comprises (a) the N-terminal amino acids 2-13 of SEQ ID NO: 2; and at least one and up to five amino acid mutations outside said N-terminal amino acids that result in differences from the wild type infestin-4 sequence; and/or (b) six conserved cysteine residues; and homology of at least 70% to the wild type Infestin-4 sequence; or (a) the N-terminal amino acids 2-13 of SEQ ID NO: 2; and at least one and up to five amino acid mutations outside said N-terminal amino acids that result in differences from the wild type infestin-4 sequence; and/or (b) six conserved cysteine residues; and homology of at least 70% to the wild type Infestin-4 sequence; (ii) an anti-FXII antibody or antigen binding fragment thereof, wherein the antibody binds to FXII and inhibits its activity and/or activation.
Multi-stage timing drive of a combustion engine with a crankshaft and at least one camshaft, wherein the timing drive comprises a primary drive, by means of which a first rotor connected to a crankshaft drives a second rotor via a first endless flexible member, wherein the second rotor is connected firmly so that it can rotate to a third rotor and wherein the third rotor is a drive element of a secondary drive, by means of which a fourth rotor connected to the at least one camshaft is driven via a second endless flexible member, wherein the second rotor and/or the third rotor exhibits a non-circular contour, and wherein the second rotor and/or the third rotor exhibits a contour with an at least simple ovality, characterised in that the amplitude of the ovality is in the region of 0.1 to 5 percent of the pitch circle diameter.
Escapement holder on which are pivotably mounted a balance and an escapement (26, 28), characterized in that it comprises a base having a right-angled cross section and a plane forming a reference surface to which the axes of rotation of the balance and of the escapement (26, 28) are perpendicular, the said plane forming, with the right-angled cross section, a right-angled triangle the hypotenuse of which is formed by the said plane, the angle between the said plane and the longer of the sides of the triangle adjacent to the right angle being nonzero.
A device comprising: a substrate, a conductive layer disposed on the substrate, the conductive layer comprising a plurality of silver nanowires, and at least one hole injection layer, hole transport layer, overcoat layer, or hole collection layer disposed on the conductive layer and comprising a water soluble or water dispersible regioregular polythiophene comprising (i) at least one organic side group substituent, and (ii) at least one sulfonate substituent comprising sulfonate sulfur bonded directly to the polythiophene backbone. a substrate, a conductive layer disposed on the substrate, the conductive layer comprising a plurality of silver nanowires, and at least one hole injection layer, hole transport layer, overcoat layer, or hole collection layer disposed on the conductive layer and comprising a water soluble or water dispersible regioregular polythiophene comprising (i) at least one organic side group substituent, and (ii) at least one sulfonate substituent comprising sulfonate sulfur bonded directly to the polythiophene backbone.
A heat generation rate waveform calculation device of an internal combustion engine, the device being configured to calculate a heat generation rate waveform of a spark-ignition internal combustion engine, wherein a period (τ) from spark generated by an ignition plug to ignition of an air-fuel mixture is defined as an ignition delay period that is one of characteristic values of the heat generation rate waveform, wherein, when the ignition time of the air-fuel mixture is on an advance side of a compression top dead center (BTDC) of a piston, the ignition delay period is estimated based on an in-cylinder fuel density at the spark time (ρ fuel@SA), the in-cylinder fuel density being obtained from an in-cylinder volume and a fuel injection amount, and when the ignition time of the air-fuel mixture is on a delay side of the compression top dead center (ATDC) of the piston, the ignition delay period is estimated based on an in-cylinder fuel density at the ignition time (ρ fuel@FA), and wherein the heat generation rate waveform is calculated using the estimated ignition delay period, wherein a virtual ignition time is set, wherein, when the virtual ignition time is on the advance side of the compression top dead center of the piston, the ignition delay period is estimated based on the in-cylinder fuel density at the spark time, and when the virtual ignition time is on the delay side of the compression top dead center of the piston, the ignition delay period is estimated based on the in-cylinder fuel density at the ignition time, wherein the estimated ignition delay period is compared with a virtual ignition delay period between an actual spark time and the virtual ignition time, wherein the proceeding is repeatedly performed so as to obtain the virtual ignition time in a case that a virtual spark time coincides with the actual spark time as a true ignition time, and wherein the heat generation rate waveform is calculated using the true ignition delay period.
Automatic welding machine for lap welding edges of plastic webs, with a movable supporting frame, a heating device for partially melting the plastic webs, at least two opposing, counter-rotating pressing rollers and advancing rollers, characterized in that the pressing rollers and advancing rollers are driven by a driving device by way of a respective flexible shaft (15, 15'), whereby the driving device comprises a drive motor and at least one gearbox for driving the pressing and advancing rollers (18 and 18' respectively) and the at least one gearbox is designed as a worm gear mechanism, preferably as a gear-reducing worm gear mechanism, whereby the worm gear mechanism comprises a worm and at least two counter-rotating worm gears (14, 14') driven by the worm.
A mid-turbine frame (57; 80) comprising: a plurality of vanes, each vane comprising: an airfoil extending between a radially outer platform and a radially inner platform; and characterised by said radially outer platform having nominally radially thinner portions (102, 103), and a pad defining a radially thicker portion, with said pad having a radial thickness that is greater than a thickness of said nominal radially thinner portions (102, 103) and said pad surrounding an outer periphery of said airfoil on a radially outer side of said radially outer platform, and said pad having a varying radial thickness; wherein said nominally radially thinner portions (102, 103) are circumferentially intermediate to adjacent airfoils of the plurality of vanes. a plurality of vanes, each vane comprising: an airfoil extending between a radially outer platform and a radially inner platform; and characterised by said radially outer platform having nominally radially thinner portions (102, 103), and a pad defining a radially thicker portion, with said pad having a radial thickness that is greater than a thickness of said nominal radially thinner portions (102, 103) and said pad surrounding an outer periphery of said airfoil on a radially outer side of said radially outer platform, and said pad having a varying radial thickness; an airfoil extending between a radially outer platform and a radially inner platform; and characterised by said radially outer platform having nominally radially thinner portions (102, 103), and a pad defining a radially thicker portion, with said pad having a radial thickness that is greater than a thickness of said nominal radially thinner portions (102, 103) and said pad surrounding an outer periphery of said airfoil on a radially outer side of said radially outer platform, and said pad having a varying radial thickness; wherein said nominally radially thinner portions (102, 103) are circumferentially intermediate to adjacent airfoils of the plurality of vanes.
A method of preparing a cathode active material, the method comprising coating a surface of a lithium transition metal oxide with a lithium boron oxide by dry mixing the lithium transition metal oxide and a boron-containing compound comprising H 3 BO 3 and performing a heat treatment in a temperature range of 130°C to 160°C.
A bleach-activating compound of the general formula (l), in which A stands for O, S, Se; Z represents an optionally substituted C 1-30 alkylene, C 3-30 cycloalkylene, arylene, alkylene arylene or arylene alkylene radical; X - stands for an anion, in particular chloride, bromide, iodide, tosylate, mesylate, triflate, sulphate, carbonate and/or phosphate; Y stands for NR 6, O, S, Se; R, R 1, R 2, R 3, R 4, R 5 and R 6 are independently H, a C 1-30 alkyl, C 3-30 cycloalkyl, aryl, alkylaryl or arylalkyl radical; and n stands for a number in the range from 1 to12, wherein 1 or more non-adjacent carbon atoms not bonded to a heteroatom in the hydrocarbon radicals may be replaced by a heteroatom, in particular N, O, S and/or Se. A stands for O, S, Se; Z represents an optionally substituted C 1-30 alkylene, C 3-30 cycloalkylene, arylene, alkylene arylene or arylene alkylene radical; X - stands for an anion, in particular chloride, bromide, iodide, tosylate, mesylate, triflate, sulphate, carbonate and/or phosphate; Y stands for NR 6, O, S, Se; R, R 1, R 2, R 3, R 4, R 5 and R 6 are independently H, a C 1-30 alkyl, C 3-30 cycloalkyl, aryl, alkylaryl or arylalkyl radical; and n stands for a number in the range from 1 to12, wherein 1 or more non-adjacent carbon atoms not bonded to a heteroatom in the hydrocarbon radicals may be replaced by a heteroatom, in particular N, O, S and/or Se.
A covered heat metering device comprising a heat metering device having at least one resting face (F A) and an opposite face (Fo) opposite the resting face (F A), said heat metering device comprising a container enclosing internal components, said container consisting of several separable and joinable parts, one of the said parts comprising or constituting the resting face (F A), the other part, or the set of the other parts, comprising or constituting an exposed part of the container that is arranged around the internal components of the heat metering device, characterized by the fact that it comprises a removable cover that covers at least a part of said heat metering device except at least the resting face (F A) thereof, said removable cover can be coupled with the container of the device by connection means present on the cover and/or by means of the shape of the cover, so that said cover can be applied to said heat metering device even when the latter is in use, i.e. when the latter is applied to a radiant terminal unit.
A spatial sensor synchronization system using a Time-Division Multiple Access (TDMA) communication system, intended for a plurality of entities evolving inside the TDMA communication system, whereby each one of the plurality of entities comprises a spatial sensor and a tag enabled to communicate in the TDMA communication system, further whereby each spatial sensor is enabled to make a spatial measurement during a determined active time period, further whereby the tags from the plurality of entities are addressed in sequence by the TDMA communication system with a determined sequence period separating two subsequent addresses in the TDMA communication system, characterised in that each of the tags comprising electrical trigger output means configured to output an electrical trigger to the sensor of the corresponding entity at the time of being addressed by the TDMA communication system, each of the sensors comprising electrical trigger input means connected to the electrical trigger output means, and configured to initiate a spatial sensor measurement for each received electrical trigger, whereby a duration of the sequence period is equal or greater than a duration of the determined active time period. each of the tags comprising electrical trigger output means configured to output an electrical trigger to the sensor of the corresponding entity at the time of being addressed by the TDMA communication system, each of the sensors comprising electrical trigger input means connected to the electrical trigger output means, and configured to initiate a spatial sensor measurement for each received electrical trigger, whereby a duration of the sequence period is equal or greater than a duration of the determined active time period.
A piston for a compressor compressing and discharging a refrigerant sucked into a cylinder, the piston comprising: a sliding portion configured to be disposed in the cylinder and having a suction space able to receive the sucked refrigerant; and a head portion coupled to the sliding portion, a compression space being formed at a front of the head portion and the suction space being formed at a rear of the head portion, the head portion comprising a suction port communicating the suction space with the compression space; characterized by a press-fit cap coupled to the front of the head portion, the press-fit cap comprising a suction hole connected to the suction port; and a first elastic member disposed between the press-fit cap and the head portion, wherein a gas layer is formed between the head portion, the press-fit cap, and the first elastic member. a sliding portion configured to be disposed in the cylinder and having a suction space able to receive the sucked refrigerant; and a head portion coupled to the sliding portion, a compression space being formed at a front of the head portion and the suction space being formed at a rear of the head portion, the head portion comprising a suction port communicating the suction space with the compression space; characterized by a press-fit cap coupled to the front of the head portion, the press-fit cap comprising a suction hole connected to the suction port; and a first elastic member disposed between the press-fit cap and the head portion, wherein a gas layer is formed between the head portion, the press-fit cap, and the first elastic member.
A method for providing access to sponsored data comprising: receiving, at a proxy server (242A, 242B, 242C), a request for first sponsored data from a first mobile subscriber of a first mobile network operator and a request for second sponsored data from a second mobile subscriber of a second mobile network operator, wherein a first sponsor is associated with the first sponsored data provided by a first Internet service provider and a second sponsor is associated with the second sponsored data provided by a second Internet service provider; serving, from the proxy server (242A, 242B, 242C), the first sponsored data to the first mobile subscriber and the second sponsored data to the second mobile subscriber; monitoring, in the proxy server (242A, 242B, 242C), a first amount of the first sponsored data being served and a second amount of the second sponsored data being served, wherein associated with the first and second sponsored data are a common top level domain, which is the same for both the first and the second sponsored data and for both the first and the second mobile network operators (102A, 102B); and unique pre-pends, which are different for the first and the second sponsored data and that identify the first sponsor and the second sponsor, wherein each unique pre-pend is concatenated, as a pre-pend, to the common top level domain, thereby generating a fully qualified domain name, and wherein the unique pre-pends are used for monitoring the first amount and the second amount. receiving, at a proxy server (242A, 242B, 242C), a request for first sponsored data from a first mobile subscriber of a first mobile network operator and a request for second sponsored data from a second mobile subscriber of a second mobile network operator, wherein a first sponsor is associated with the first sponsored data provided by a first Internet service provider and a second sponsor is associated with the second sponsored data provided by a second Internet service provider; serving, from the proxy server (242A, 242B, 242C), the first sponsored data to the first mobile subscriber and the second sponsored data to the second mobile subscriber; monitoring, in the proxy server (242A, 242B, 242C), a first amount of the first sponsored data being served and a second amount of the second sponsored data being served, wherein associated with the first and second sponsored data are a common top level domain, which is the same for both the first and the second sponsored data and for both the first and the second mobile network operators (102A, 102B); and unique pre-pends, which are different for the first and the second sponsored data and that identify the first sponsor and the second sponsor, wherein each unique pre-pend is concatenated, as a pre-pend, to the common top level domain, thereby generating a fully qualified domain name, and wherein the unique pre-pends are used for monitoring the first amount and the second amount.
A pharmaceutical composition for use in the prevention and treatment of atopy comprising a compound represented by the following formula 1: wherein, R is -C 6 H 5 or -CH=CHCH=CH(CH 2) 4 CH 3.
A transmission assembly for velocipedes without any bottom bracket comprising a ring gear rotating around an axis parallel to the axes of the wheels of the velocipede, motion transmission means suitable for engaging said ring gear and suitable for transferring the rotation of said ring gear to the driving wheel or to the driving wheels of the velocipede, two sets of bearings fixed on each side of the frame respectively along the perimeter of a disc-shaped cavity inside which said ring gear is coaxially accommodated, the outer circumferential edge of the latter featuring on every side at least one sliding annular surface (21, 22) slidingly resting on said bearings thus enabling said ring gear to rotate freely with respect to said disc-shaped cavity, characterized in that said ring gear is joined via two or more spokes to the median section of a rod with the opposite ends (51, 52) of which the pedals (71, 72) are rotationally coupled, said rod having an axis of symmetry oblique with respect to said axis which it intersects in correspondence with the center of gravity of said ring gear.
Method for monitoring the driveability of the ground by a self-propelled agricultural work machine which is equipped with at least one optical sensor, characterized in that at least one track left behind by a tyre of the work machine as well as the ground next to the track is optically captured at least in sections by the at least one sensor and in that conclusions about the ground conditions are drawn through image analysis.
An isolated heteromultimer Fc construct comprising a modified heterodimeric CH3 domain, the modified heterodimeric CH3 domain comprising: a first modified CH3 domain polypeptide and a second modified CH3 domain polypeptide; wherein the first modified CH3 domain polypeptide comprises amino acid substitutions at positions L351, F405 and Y407, and the second modified CH3 domain polypeptide comprises amino acid substitutions at positions T366, K392 and T394 as compared to the CH3 domain of the heavy chain IgG1 sequence as set forth in Table B, wherein the amino acid substitution at position L351 is L351Y, the amino acid substitution at position F405 is F405A, the amino acid substitution at position Y407 is Y407V, the amino acid substitution at position T366 is T366I or T366L, the amino acid substitution at position K392 is K392L or K392M, and the amino acid substitution at position T394 is T394W; further wherein at least one of the first and second modified CH3 domain polypeptides comprises a T350V substitution; further wherein the heterodimeric CH3 domain has a melting temperature (Tm) of at least 74°C and a purity of at least 95%; further wherein the heteromultimer Fc construct is based on a human type G immunoglobulin 1; and further wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat. a first modified CH3 domain polypeptide and a second modified CH3 domain polypeptide; wherein the first modified CH3 domain polypeptide comprises amino acid substitutions at positions L351, F405 and Y407, and the second modified CH3 domain polypeptide comprises amino acid substitutions at positions T366, K392 and T394 as compared to the CH3 domain of the heavy chain IgG1 sequence as set forth in Table B, wherein the amino acid substitution at position L351 is L351Y, the amino acid substitution at position F405 is F405A, the amino acid substitution at position Y407 is Y407V, the amino acid substitution at position T366 is T366I or T366L, the amino acid substitution at position K392 is K392L or K392M, and the amino acid substitution at position T394 is T394W; further wherein at least one of the first and second modified CH3 domain polypeptides comprises a T350V substitution; further wherein the heterodimeric CH3 domain has a melting temperature (Tm) of at least 74°C and a purity of at least 95%; further wherein the heteromultimer Fc construct is based on a human type G immunoglobulin 1; and further wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat.
A steering damper apparatus for a saddle-ride type vehicle, comprising a pump unit disposed between a vehicle body frame and a steering element that configures part of a steering, the pump unit including: a pump case that has a cylinder hole having opposite ends thereof closed; a piston that is slidably fitted in the cylinder hole to thereby form an oil chamber between the piston and the pump case, the oil chamber being to be filled with damper oil; and a piston rod that is coaxially continuous to the piston and passes through one end portion of the pump case, characterized in that said pump unit, comprises a pair of pump units that are respectively disposed on left and right sides of an imaginary plane that passes through a center of rotation of the steering so as to extend in a vehicle fore-aft direction, and a flexible pipe line connects between the pump units.
A topical glycopyrrolate formulation comprising: 0.25 to 6% w/w of a glycopyrrolate compound which is glycopyrronium bromide, ethanol and water in a weight ratio of 50:50 to 70:30, and a buffering agent at an amount sufficient to maintain a pH of 3.5 to 6. 0.25 to 6% w/w of a glycopyrrolate compound which is glycopyrronium bromide, ethanol and water in a weight ratio of 50:50 to 70:30, and a buffering agent at an amount sufficient to maintain a pH of 3.5 to 6.
System comprising a stand part of a food processor and a stand part of a mixing device and at least one vessel with a mixing tool located therein, wherein the vessel can be both part of the food processor and as part of the stirring device, wherein the maximum possible rotational speed at which the stand part of the food processor can rotate the mixing tool is at least five times greater than the maximum possible rotational speed at which the stand part of the mixing device can rotate the mixing tool.