A compound having one of the following structures (VIa'), (VIb'), (VIc'), (VId'), (VIe'), (VIf') or (VIg'): or or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein the prodrug is selected from the group consisting of acetate, formate and benzoate derivatives of a hydroxy functional group, or acetamide, formamide and benzamide derivatives of an amine functional group in the compound; wherein: i) G 3 is N and G 4 is CR; or ii) G 3 is CR and G 4 is N; or iii) G 3 is N and G 4 is N, wherein R is H, cyano, halo or C 1 -C 6 alkyl; L 1a is a bond, -NH-, alkylene or heteroalkylene; L 2 is a bond or alkylene; R 32a and R 32b are, at each occurrence, independently H, -OH, -NH 2, -CO 2 H, cyano, cyanoalkyl, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl; or R 32a and R 32b join to form a carbocyclic or heterocyclic ring; or R 32a is H, -OH, -NH 2, -CO 2 H, cyano, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl and R 32b joins with R 33b to form a carbocyclic or heterocyclic ring; R 33a and R 33b are, at each occurrence, independently H, -OH, -NH 2, -CO 2 H, cyano, cyanoalkyl, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl; or R 33a and R 33b join to form a carbocyclic or heterocyclic ring; or R 33a is H, -OH, -NH 2, -CO 2 H, cyano, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl and R 33b joins with R 32b to form a carbocyclic or heterocyclic ring; R 37a, R 37b, R 37c, R 37d and R 37e are each independently H, halo, oxo, hydroxyl, cyano, aminocarbonyl, formyl, C 1 -C 6 alkyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 hydroxylalkyl, C 1 -C 6 alkoxyalkyl, C 1 -C 6 aminoalkyl, heterocyclyl or aryl, wherein: i) R 37a or R 37e is aryl, or ii) R 37a or R 37e, or both, are chloro, bromo or iodo; R 38a, R 38b and R 38c are each independently H, C 1 -C 6 alkyl or aryl; n 3 and n 4 are each independently 1, 2 or 3; Q is -C(=O)-, -NR 34 C(=O)-, -S(=O) 2 - or - NR 34 S(=O) 2 -; R 34 is H, C 1 -C 6 alkyl or hydroxylalkyl; is a carbon-carbon double bond or a carbon-carbon triple bond; and R 35 and R 36 are each independently H, cyano, C 1 -C 6 alkyl, aminoalkyl, alkylaminoalkyl, or hydroxylalkyl, wherein at least one of R 35 or R 36 is H, wherein each occurrence of alkyl, alkylene, heteroalkylene, cyanoalkyl, cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl, aminocarbonyl, alkylsulfonyl, carbocyclic ring, heterocyclic ring, haloalkyl, alkoxy, alkoxyalkyl, heterocyclyl, aryl or alkylaminoalkyl is optionally substituted unless otherwise specified. i) G 3 is N and G 4 is CR; or ii) G 3 is CR and G 4 is N; or iii) G 3 is N and G 4 is N, wherein R is H, cyano, halo or C 1 -C 6 alkyl; L 1a is a bond, -NH-, alkylene or heteroalkylene; L 2 is a bond or alkylene; R 32a and R 32b are, at each occurrence, independently H, -OH, -NH 2, -CO 2 H, cyano, cyanoalkyl, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl; or R 32a and R 32b join to form a carbocyclic or heterocyclic ring; or R 32a is H, -OH, -NH 2, -CO 2 H, cyano, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl and R 32b joins with R 33b to form a carbocyclic or heterocyclic ring; R 33a and R 33b are, at each occurrence, independently H, -OH, -NH 2, -CO 2 H, cyano, cyanoalkyl, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl; or R 33a and R 33b join to form a carbocyclic or heterocyclic ring; or R 33a is H, -OH, -NH 2, -CO 2 H, cyano, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl or aminocarbonyl and R 33b joins with R 32b to form a carbocyclic or heterocyclic ring; R 37a, R 37b, R 37c, R 37d and R 37e are each independently H, halo, oxo, hydroxyl, cyano, aminocarbonyl, formyl, C 1 -C 6 alkyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 hydroxylalkyl, C 1 -C 6 alkoxyalkyl, C 1 -C 6 aminoalkyl, heterocyclyl or aryl, wherein: i) R 37a or R 37e is aryl, or ii) R 37a or R 37e, or both, are chloro, bromo or iodo; R 38a, R 38b and R 38c are each independently H, C 1 -C 6 alkyl or aryl; n 3 and n 4 are each independently 1, 2 or 3; Q is -C(=O)-, -NR 34 C(=O)-, -S(=O) 2 - or - NR 34 S(=O) 2 -; R 34 is H, C 1 -C 6 alkyl or hydroxylalkyl; is a carbon-carbon double bond or a carbon-carbon triple bond; and R 35 and R 36 are each independently H, cyano, C 1 -C 6 alkyl, aminoalkyl, alkylaminoalkyl, or hydroxylalkyl, wherein at least one of R 35 or R 36 is H, wherein each occurrence of alkyl, alkylene, heteroalkylene, cyanoalkyl, cycloalkyl, hydroxylalkyl, aminoalkyl, carboxylalkyl, aminocarbonyl, alkylsulfonyl, carbocyclic ring, heterocyclic ring, haloalkyl, alkoxy, alkoxyalkyl, heterocyclyl, aryl or alkylaminoalkyl is optionally substituted unless otherwise specified.