A ventilator system comprising: an outlet line; a pump configured to increase pressure in the outlet line of the ventilator during periodic inspiration pulses of an inspiration cycle of the ventilator; and a ventilator diagnostic Volatile Organic Compounds, VOC, sample collection system comprising: a sample collection device, the sample collection device including a cavity containing one or more sorbents; and a valve system coupled to an opening of the cavity of the sample collection system, the valve system comprising a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system, wherein: the valve system is configured to be coupled to the ventilator outlet line, the sample collection system is configured to allow the flow of gas into the sample collection system via the first one-way valve to occur during periodic inspiration pulses of an inspiration cycle of a ventilator, the sample collection system is configured to allow the flow of gas out of the sample collection system and into the ventilator outlet line via the second one-way valve to occur between the periodic inspiration pulses of the inspiration cycle of the ventilator, a pump of the ventilator increases pressure in the ventilator outlet line during the periodic inspiration pulses of the ventilator, the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line, and the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator. an outlet line; a pump configured to increase pressure in the outlet line of the ventilator during periodic inspiration pulses of an inspiration cycle of the ventilator; and a ventilator diagnostic Volatile Organic Compounds, VOC, sample collection system comprising: a sample collection device, the sample collection device including a cavity containing one or more sorbents; and a valve system coupled to an opening of the cavity of the sample collection system, the valve system comprising a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system, wherein: the valve system is configured to be coupled to the ventilator outlet line, the sample collection system is configured to allow the flow of gas into the sample collection system via the first one-way valve to occur during periodic inspiration pulses of an inspiration cycle of a ventilator, the sample collection system is configured to allow the flow of gas out of the sample collection system and into the ventilator outlet line via the second one-way valve to occur between the periodic inspiration pulses of the inspiration cycle of the ventilator, a pump of the ventilator increases pressure in the ventilator outlet line during the periodic inspiration pulses of the ventilator, the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line, and the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator. a sample collection device, the sample collection device including a cavity containing one or more sorbents; and a valve system coupled to an opening of the cavity of the sample collection system, the valve system comprising a first one-way valve that allows flow of gas into the sample collection system and a second one-way valve that allows flow of gas out of the sample collection system, wherein: the valve system is configured to be coupled to the ventilator outlet line, the sample collection system is configured to allow the flow of gas into the sample collection system via the first one-way valve to occur during periodic inspiration pulses of an inspiration cycle of a ventilator, the sample collection system is configured to allow the flow of gas out of the sample collection system and into the ventilator outlet line via the second one-way valve to occur between the periodic inspiration pulses of the inspiration cycle of the ventilator, a pump of the ventilator increases pressure in the ventilator outlet line during the periodic inspiration pulses of the ventilator, the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line, and the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator. the valve system is configured to be coupled to the ventilator outlet line, the sample collection system is configured to allow the flow of gas into the sample collection system via the first one-way valve to occur during periodic inspiration pulses of an inspiration cycle of a ventilator, the sample collection system is configured to allow the flow of gas out of the sample collection system and into the ventilator outlet line via the second one-way valve to occur between the periodic inspiration pulses of the inspiration cycle of the ventilator, a pump of the ventilator increases pressure in the ventilator outlet line during the periodic inspiration pulses of the ventilator, the flow of gas into the sample collection system is actuated by the pump of the ventilator that is coupled to the sample collection system by way of the ventilator outlet line, and the flow of gas out of the sample collection system is facilitated by an outlet valve of the ventilator.