An apparatus configured to measure luminescence from a multi-well plate, the multi-well plate having a plurality of wells comprising a plate top and a plate bottom, the plate bottom defining the bottom of said plurality of wells and comprising a substrate having: (x) a top surface including at least four electrodes (1052, 1054), at least a portion of each one of said at least four electrodes (1052, 1054) being exposed within a well of said plurality of wells, wherein said at least four electrodes (1052, 1054) comprises at least two working electrodes and at least two counter electrodes, wherein each counter electrode is associated with a corresponding working electrode, and wherein at least a portion of one working electrode and a corresponding counter electrode is exposed within each well of said plurality of wells; (y) a bottom surface comprising two or more electrical contact surfaces (1072, 1074), wherein said bottom surface comprises a first electrical contact surface associated with said at least two working electrodes and a second electrical contact surface associated with said at least two counter electrodes; and (z) four or more conductive through-holes (1062, 1064) electrically connecting said two or more electrical contact surfaces (1072, 1074) with said at least four electrodes (1052, 1054); and (zz) a plurality of independent electrode sectors, a sector comprising (i) at least one pair of working and associated counter electrodes (1052, 1054) on said top surface, and (ii) at least two electrical contact surfaces (1072, 1074) on said bottom surface; said apparatus comprising a photodetector for measuring emitted luminescence from at least a portion of the plurality of wells, an optical system, a plate transport mechanism, a plate electrical connector mechanism adapted to make and break contact with said two or more contact surfaces (1072, 1074) in one of said plurality of independent electrode sectors of said multi-well plate, and a plate alignment mechanism configured to align one or more of said plurality of independent electrode sectors with said optical system and said plate electrical connector mechanism. (x) a top surface including at least four electrodes (1052, 1054), at least a portion of each one of said at least four electrodes (1052, 1054) being exposed within a well of said plurality of wells, wherein said at least four electrodes (1052, 1054) comprises at least two working electrodes and at least two counter electrodes, wherein each counter electrode is associated with a corresponding working electrode, and wherein at least a portion of one working electrode and a corresponding counter electrode is exposed within each well of said plurality of wells; (y) a bottom surface comprising two or more electrical contact surfaces (1072, 1074), wherein said bottom surface comprises a first electrical contact surface associated with said at least two working electrodes and a second electrical contact surface associated with said at least two counter electrodes; and (z) four or more conductive through-holes (1062, 1064) electrically connecting said two or more electrical contact surfaces (1072, 1074) with said at least four electrodes (1052, 1054); and (zz) a plurality of independent electrode sectors, a sector comprising (i) at least one pair of working and associated counter electrodes (1052, 1054) on said top surface, and (ii) at least two electrical contact surfaces (1072, 1074) on said bottom surface; said apparatus comprising a photodetector for measuring emitted luminescence from at least a portion of the plurality of wells, an optical system, a plate transport mechanism, a plate electrical connector mechanism adapted to make and break contact with said two or more contact surfaces (1072, 1074) in one of said plurality of independent electrode sectors of said multi-well plate, and a plate alignment mechanism configured to align one or more of said plurality of independent electrode sectors with said optical system and said plate electrical connector mechanism.