mhurhangee/ep-ind-claims huggingface dataset:
A method of attaching a target molecule to a substrate, the method comprising: a) providing a reagent composition comprising a hydrophilic polymer backbone having a random distribution of thermochemically reactive groups formed by polymerization of monomers having a polymerizable group separated by a spacer group from a thermochemically reactive group, and optionally monomers having a polymerizable group separated by a spacer group from a photo reactive group, and monomers which are neither photo reactive nor thermochemically reactive, wherein the thermo chemically reactive groups on the hydrophilic polymer backbone are configured and arranged to form covalent bonds with functional groups on the target molecule; b) coating and immobilizing the reagent composition on the substrate to form a bound composition; c) providing a solution comprising target molecule having one or more functional groups reactive with the thermochemically reactive groups provided by the bound composition; d) applying one or more spots of the solution with a volume of between 0.01 nanoliter and 100 nanoliters to the substrate; and e) allowing the thermo chemically reactive groups provided by the bound composition to form covalent bonds with the functional groups provided by the target molecule in order to attach the target molecule to the substrate, without use of attracting groups to attract the target molecule to the bound reagent. a) providing a reagent composition comprising a hydrophilic polymer backbone having a random distribution of thermochemically reactive groups formed by polymerization of monomers having a polymerizable group separated by a spacer group from a thermochemically reactive group, and optionally monomers having a polymerizable group separated by a spacer group from a photo reactive group, and monomers which are neither photo reactive nor thermochemically reactive, wherein the thermo chemically reactive groups on the hydrophilic polymer backbone are configured and arranged to form covalent bonds with functional groups on the target molecule; b) coating and immobilizing the reagent composition on the substrate to form a bound composition; c) providing a solution comprising target molecule having one or more functional groups reactive with the thermochemically reactive groups provided by the bound composition; d) applying one or more spots of the solution with a volume of between 0.01 nanoliter and 100 nanoliters to the substrate; and e) allowing the thermo chemically reactive groups provided by the bound composition to form covalent bonds with the functional groups provided by the target molecule in order to attach the target molecule to the substrate, without use of attracting groups to attract the target molecule to the bound reagent.
A method of establishing valve clearance using a valve-clearance and adjustment system to set a valve clearance gap at a valve stem using a valve adjustment screw disposed in a rocker arm, the valve clearance and adjustment system including a shim (200, 712) sized and configured to create a desired valve clearance gap when the shim is secured between a locking mechanism (300, 500, 716, 720, 800, 900, 1000) and the rocker arm, the method comprising: adjusting the adjustment screw to substantially eliminate the valve clearance gap; positioning the locking mechanism on the adjustment screw such that the locking mechanism abuts the rocker arm; adjusting the adjustment screw such that the shim can be placed between the locking mechanism and the rocker arm; positioning the shim between the locking mechanism and the rocker arm; adjusting the adjustment screw such that the shim contacts the rocker arm and the locking mechanism; and arranging the locking mechanism such that the shim is locked in place between the locking mechanism and the rocker arm. adjusting the adjustment screw to substantially eliminate the valve clearance gap; positioning the locking mechanism on the adjustment screw such that the locking mechanism abuts the rocker arm; adjusting the adjustment screw such that the shim can be placed between the locking mechanism and the rocker arm; positioning the shim between the locking mechanism and the rocker arm; adjusting the adjustment screw such that the shim contacts the rocker arm and the locking mechanism; and arranging the locking mechanism such that the shim is locked in place between the locking mechanism and the rocker arm.
Grafted heterophasic propylene copolymer composition, which comprises 30.0 to 95.0 wt% of a heterophasic polypropylene copolymer having a melt flow rate (MFR 230°C/2.16kg, ISO1133) of from 0.1 to 100 g/10min and comprising a matrix being a crystalline polypropylene homo- or copolymer and and elastomeric copolymer dispersed in said matrix and 5.0 to 70.0 wt% of a styrene-based elastomer being a unsaturated styrene block copolymer containing at least one diene comonomer and having a styrene content of from 5.0 to 50.0 wt% measured by Fourier transform infrared spectroscopy (FTIR), and wherein the styrene-based elastomer is grafted onto the base heterophasic polypropylene copolymer, wherein the grafted heterophasic propylene copolymer composition has an impact strength measured according to the Charpy notched impact test according to ISO 179 at -20°C of at least 15.0 kJ/m 2, impact strength measured according to the Charpy notched impact test according to ISO 179 at -30°C of at least 7.0 kJ/m 2 and F30 melt strength of at least 3.0 cN measured with the Rheotens test at 200°C according to ISO 16790:2005. 30.0 to 95.0 wt% of a heterophasic polypropylene copolymer having a melt flow rate (MFR 230°C/2.16kg, ISO1133) of from 0.1 to 100 g/10min and comprising a matrix being a crystalline polypropylene homo- or copolymer and and elastomeric copolymer dispersed in said matrix and a matrix being a crystalline polypropylene homo- or copolymer and and elastomeric copolymer dispersed in said matrix and 5.0 to 70.0 wt% of a styrene-based elastomer being a unsaturated styrene block copolymer containing at least one diene comonomer and having a styrene content of from 5.0 to 50.0 wt% measured by Fourier transform infrared spectroscopy (FTIR), and wherein the styrene-based elastomer is grafted onto the base heterophasic polypropylene copolymer, wherein the grafted heterophasic propylene copolymer composition has an impact strength measured according to the Charpy notched impact test according to ISO 179 at -20°C of at least 15.0 kJ/m 2, impact strength measured according to the Charpy notched impact test according to ISO 179 at -30°C of at least 7.0 kJ/m 2 and F30 melt strength of at least 3.0 cN measured with the Rheotens test at 200°C according to ISO 16790:2005.
A grid plate assembly for use in a reactor for the hydroconversion of hydrocarbon feedstock with a hydrogen gas at elevated temperature and pressure with the use of a catalyst, comprising: a grid plate dividing the reactor into two zones, a zone above the grid plate and a zone below the grid plate; a bubble cap assembly comprising a plurality of tubular risers extending through the grid plate to transmit the hydrogen gas and hydrocarbon feedstock from the zone below the grid plate to the zone above the grid plate; each tubular riser having an upper section above the grid plate and a lower section below the grid plate, the lower section terminated with an open bottom end for ingress of the hydrogen gas and hydrocarbon feedstock, the upper section having a closed top terminated with a housing cap; the lower section of the tubular riser having at least a vertical slot extending from the open bottom end; the lower section of the tubular riser having at least a side hole opening sufficiently sized and located such that in operation, liquid level in the zone below the grid plate is above the vertical slot and below the side hole opening. a grid plate dividing the reactor into two zones, a zone above the grid plate and a zone below the grid plate; a bubble cap assembly comprising a plurality of tubular risers extending through the grid plate to transmit the hydrogen gas and hydrocarbon feedstock from the zone below the grid plate to the zone above the grid plate; each tubular riser having an upper section above the grid plate and a lower section below the grid plate, the lower section terminated with an open bottom end for ingress of the hydrogen gas and hydrocarbon feedstock, the upper section having a closed top terminated with a housing cap; the lower section of the tubular riser having at least a vertical slot extending from the open bottom end; the lower section of the tubular riser having at least a side hole opening sufficiently sized and located such that in operation, liquid level in the zone below the grid plate is above the vertical slot and below the side hole opening.
A Compound of Formula I: wherein: X is -N -, or -N(CH 3)-; L is O; Z is -O-; optionally in deuterated form, in free or pharmaceutically acceptable salt form for use in a method for the acute treatment of depression and/or anxiety; the method comprising administering to a patient in need thereof, a therapeutically effective amount of a compound of Formula I. X is -N -, or -N(CH 3)-; L is O; Z is -O-; optionally in deuterated form,
Digital microscope, having - an optics unit and a digital image processing unit, which are arranged at a pivotable microscope stand, and having - a microscope image sensor for capturing a microscopic image of a sample to be arranged on a sample stage, - at least one first monitoring sensor embodied in the form of an image sensor or a camera for capturing a two-dimensional overview image of the sample; - a monitoring unit, wherein data of the first monitoring sensor are evaluated automatically in the monitoring unit, - a second monitoring sensor, which is an image sensor (06, 07, 08) or a camera for capturing an overview image, wherein the first monitoring sensor and the second monitoring sensor are arranged at the digital microscope at spatially different locations, characterized in that - the data of both monitoring sensors are processed in the monitoring unit to produce three-dimensional overview information that is used to automatically control a workflow of the digital microscope, wherein the workflow comprises at least controlling the sample stage and/or controlling the optics unit. - an optics unit and a digital image processing unit, which are arranged at a pivotable microscope stand, and having - a microscope image sensor for capturing a microscopic image of a sample to be arranged on a sample stage, - at least one first monitoring sensor embodied in the form of an image sensor or a camera for capturing a two-dimensional overview image of the sample; - a monitoring unit, wherein data of the first monitoring sensor are evaluated automatically in the monitoring unit, - a second monitoring sensor, which is an image sensor (06, 07, 08) or a camera for capturing an overview image, wherein the first monitoring sensor and the second monitoring sensor are arranged at the digital microscope at spatially different locations, characterized in that - the data of both monitoring sensors are processed in the monitoring unit to produce three-dimensional overview information that is used to automatically control a workflow of the digital microscope, wherein the workflow comprises at least controlling the sample stage and/or controlling the optics unit.
A gas stove, comprising a top sheet, a gas valve, which has an actuation stem for actuating the gas valve, an actuation knob for actuating the actuation stem, and a gasket, which is at least partly arranged between the actuation knob and the top sheet, wherein the gasket has a cone-shaped outer circumferential wall that is at least partly received inside the actuation knob, wherein the outer circumferential wall axially and radially seals against the actuation knob, wherein the outer circumferential wall diverges from an axis of symmetry of the gasket when seen along a longitudinal direction of the gasket, wherein the gasket comprises a cone-shaped basic section, wherein the outer circumferential wall protrudes from the basic section along the longitudinal direction, characterized in that the gasket comprises an inner circumferential wall that protrudes from the basic section along the longitudinal direction.
Method for producing spectacle lenses having multifocal power, characterized in that the spectacle lenses are produced from semifinished products with spherical or aspherical rotationally symmetrical convex front surfaces with a small number of different radii such that the total dioptric power adaptation which is individually necessary is performed by means of the back surface, embodied as a progressive surface, of the spectacle lens, wherein a requirement profile in respect of the spectacle lens is formulated, consisting of dioptric desired powers, namely spherical, astigmatic, prismatic, at different points distributed over the spectacle lens or over the whole area, wherein this includes the desired power at the near and far reference points.
Precipitated silica, characterized in that it has: - a BET specific surface of between 45 and 550 m 2 /g, in particular between 70 and 370 m 2 /g, especially between 80 and 300 m 2 /g, - a content of polycarboxylic acid + corresponding carboxylate, expressed as total carbon, of at least 0.15% by weight, in particular of at least 0.20% by weight, - an aluminum (Al) content of at least 0.20% by weight, in particular of at least 0.25% by weight, and in that it exhibits, at its surface, molecules of a mixture of polycarboxylic acids and said polycarboxylic acids are chosen from adipic acid, succinic acid, ethylsuccinic acid, glutaric acid, methylglutaric acid, oxalic acid or citric acid. - a BET specific surface of between 45 and 550 m 2 /g, in particular between 70 and 370 m 2 /g, especially between 80 and 300 m 2 /g, - a content of polycarboxylic acid + corresponding carboxylate, expressed as total carbon, of at least 0.15% by weight, in particular of at least 0.20% by weight, - an aluminum (Al) content of at least 0.20% by weight, in particular of at least 0.25% by weight, and
A method of segmenting biological cells in a picture, so that the biological cells represent a foreground of the picture, the method comprising: applying (110; 405) a first fast marching algorithm to the picture or to a pre-processed version of same so as to achieve a first fast marching image, the first fast marching algorithm starting from a background of the picture, and a velocity function of the first fast marching algorithm being based on a first edge-strength image of the picture; segmenting (120; 603) the first fast marching image or a further-processed version of same into a plurality of homogeneous regions; mapping (130; 605) each of the homogeneous regions to one node, respectively, of a graph so that nodes of adjacent homogeneous regions are connected to one another and so that the graph comprises roots which correspond to homogeneous regions located at cell centers; classifying (140; 607), on the basis of the graph, each homogeneous region either as background or as foreground; and applying (150; 208) a second fast marching algorithm within the homogeneous regions classified as foreground to a second edge-strength image so as to segment the foreground into individual biological cells, the second fast marching algorithm starting from those homogeneous regions which correspond to the roots of the graph. applying (110; 405) a first fast marching algorithm to the picture or to a pre-processed version of same so as to achieve a first fast marching image, the first fast marching algorithm starting from a background of the picture, and a velocity function of the first fast marching algorithm being based on a first edge-strength image of the picture; segmenting (120; 603) the first fast marching image or a further-processed version of same into a plurality of homogeneous regions; mapping (130; 605) each of the homogeneous regions to one node, respectively, of a graph so that nodes of adjacent homogeneous regions are connected to one another and so that the graph comprises roots which correspond to homogeneous regions located at cell centers; classifying (140; 607), on the basis of the graph, each homogeneous region either as background or as foreground; and applying (150; 208) a second fast marching algorithm within the homogeneous regions classified as foreground to a second edge-strength image so as to segment the foreground into individual biological cells, the second fast marching algorithm starting from those homogeneous regions which correspond to the roots of the graph.
A hair treatment composition comprising: i) a Polyacrylate crosspolymer which is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate, and ii) an acrylic pressure sensitive adhesive which is 98% ButylAcrylate, 2% MethylAcrylic Acid. i) a Polyacrylate crosspolymer which is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate, and ii) an acrylic pressure sensitive adhesive which is 98% ButylAcrylate, 2% MethylAcrylic Acid.
A head for an oral care implement, the head having a mounting surface comprising at least one tuft of a first length and at least one tuft of a second length, the first length being longer than the second length measured from the mounting surface of the head along a longitudinal axis of the tufts (16, 18), the at least one tuft of the first length comprising filaments having a substantially circular cross-sectional area extending in a plane perpendicular to the longitudinal axis and an end-rounded free end, characterized in that the at least one tuft of the second length comprises flagged filaments having split free ends. the at least one tuft of the first length comprising filaments having a substantially circular cross-sectional area extending in a plane perpendicular to the longitudinal axis and an end-rounded free end, characterized in that the at least one tuft of the second length comprises flagged filaments having split free ends.
A resource allocation method that comprises: determining one physical channel area among multiple physical channel areas; and notifying the determined physical channel area to a User Equipment, UE, through signaling so as to enable the UE to determine a confirmation information channel in the determined physical channel area according to a mapping rule, wherein each of the multiple physical channel areas comprises at least one confirmation information channel, and the mapping rule is a principle of selecting a confirmation information channel in the determined physical channel area for sending or receiving ACK/NACK information, and the method is characterised in that the multiple physical channel areas comprises: a Coordinated Multi-Point, CoMP, area and a non-CoMP area, the CoMP area is used by CoMP users exclusively for sending ACK/NACK information, and the ACK/NACK information sent in the CoMP area is modulated through sequences specific to CoMP users. determining one physical channel area among multiple physical channel areas; and notifying the determined physical channel area to a User Equipment, UE, through signaling so as to enable the UE to determine a confirmation information channel in the determined physical channel area according to a mapping rule, wherein each of the multiple physical channel areas comprises at least one confirmation information channel, and the mapping rule is a principle of selecting a confirmation information channel in the determined physical channel area for sending or receiving ACK/NACK information, and the method is characterised in that the multiple physical channel areas comprises: a Coordinated Multi-Point, CoMP, area and a non-CoMP area, the CoMP area is used by CoMP users exclusively for sending ACK/NACK information, and the ACK/NACK information sent in the CoMP area is modulated through sequences specific to CoMP users.
A method for processing culinary nuts, comprising the steps of: a) adding water to non-shelled culinary nuts to form a suspension; b) wet grinding said suspension in one or more steps to an average particle size of less than 100 μm; and c) separating the suspension into at least a solid phase comprising culinary nut solids and a liquid phase comprising culinary nut milk, wherein the culinary nuts subjected to wet grinding include nuts selected from hazelnuts, almonds, walnuts, cashews, pistachios, pecans, macadamia nuts, peanuts, kola nuts, palm nuts, Brazil nuts, chestnuts, and combinations thereof. a) adding water to non-shelled culinary nuts to form a suspension; b) wet grinding said suspension in one or more steps to an average particle size of less than 100 μm; and c) separating the suspension into at least a solid phase comprising culinary nut solids and a liquid phase comprising culinary nut milk,
A laminated lithographic printing plate comprising: an aluminum layer having a first side and a second side, a first aluminum oxide layer coating the first side of the aluminum layer, a second aluminum oxide layer coating the second side of the aluminum layer, an image forming layer coating the first aluminum oxide layer, an adhesive layer adhering to said second aluminum oxide layer, and a base layer coating the adhesive layer, the adhesive layer being accessible to and insoluble in oleophilic inks and alkaline or acidic aqueous fountain solutions used during printing with the printing plate, and alkaline or acidic aqueous developers used during development of the printing plate, and the adhesive layer being a dry adhesive compliant layer having a hardness of 60 Shore-A or less, thereby allowing delamination of the printing plate. an aluminum layer having a first side and a second side, a first aluminum oxide layer coating the first side of the aluminum layer, a second aluminum oxide layer coating the second side of the aluminum layer, an image forming layer coating the first aluminum oxide layer, an adhesive layer adhering to said second aluminum oxide layer, and a base layer coating the adhesive layer, a dry adhesive compliant layer having a hardness of 60 Shore-A or less, thereby allowing delamination of the printing plate.
A computer-implemented method of determining an antimicrobial drug, e.g. antibiotic, resistance profile for a microorganism, particularly a bacterial microorganism, comprising: obtaining or providing a first data set of gene sequences of a plurality of clinical isolates of the microorganism; wherein at least a part of the gene sequences of the first data set are assembled; analyzing the gene sequences of the first data set for genetic variants to obtain a third data set of genetic variants, wherein the genetic variants in the gene sequences of the first data set are detected alignment-free; providing a second data set of antimicrobial drug, e.g. antibiotic, resistance and/or susceptibility of the plurality of clinical isolates of the microorganism; correlating the third data set with the second data set and statistically analyzing the correlation; and determining the genetic sites in the genome of the microorganism with antimicrobial drug, e.g. antibiotic, resistance. obtaining or providing a first data set of gene sequences of a plurality of clinical isolates of the microorganism; wherein at least a part of the gene sequences of the first data set are assembled; analyzing the gene sequences of the first data set for genetic variants to obtain a third data set of genetic variants, wherein the genetic variants in the gene sequences of the first data set are detected alignment-free; providing a second data set of antimicrobial drug, e.g. antibiotic, resistance and/or susceptibility of the plurality of clinical isolates of the microorganism; correlating the third data set with the second data set and statistically analyzing the correlation; and determining the genetic sites in the genome of the microorganism with antimicrobial drug, e.g. antibiotic, resistance.