A method for operating a system for air-conditioning an interior, in particular of a vehicle, - the system having a room air-conditioning device for conditioning air located in the interior or in ducted therein, at least one seat device comprising a seat air-conditioning device for conditioning a side of the seat device facing a passenger, and a control unit for controlling the room air-conditioning device and the seat air-conditioning device, - wherein said method according to an offset control mode comprises the steps of a) setting of a target temperature for the interior, b) measurement of an actual temperature in the interior, and c) if seat air-conditioning device is active, controlling the actual temperature to the target temperature with an offset value taken into account by using the control unit and the room air-conditioning device controlled accordingly therefrom, the offset value being used to increase a control tolerance (variant 1) and/or a control hysteresis (variant 3) and/or to reduce a power input or a climatic power output of the room air-conditioning device (variant 2), - wherein a standard control mode is additionally provided, in which a target value of the temperature serves as the reference variable without using the offset value, and - wherein a condition for the operation of the system is provided for switching between standard control mode and offset control mode. - the system having a room air-conditioning device for conditioning air located in the interior or in ducted therein, at least one seat device comprising a seat air-conditioning device for conditioning a side of the seat device facing a passenger, and a control unit for controlling the room air-conditioning device and the seat air-conditioning device, - wherein said method according to an offset control mode comprises the steps of a) setting of a target temperature for the interior, b) measurement of an actual temperature in the interior, and c) if seat air-conditioning device is active, controlling the actual temperature to the target temperature with an offset value taken into account by using the control unit and the room air-conditioning device controlled accordingly therefrom, the offset value being used to increase a control tolerance (variant 1) and/or a control hysteresis (variant 3) and/or to reduce a power input or a climatic power output of the room air-conditioning device (variant 2), a) setting of a target temperature for the interior, b) measurement of an actual temperature in the interior, and c) if seat air-conditioning device is active, controlling the actual temperature to the target temperature with an offset value taken into account by using the control unit and the room air-conditioning device controlled accordingly therefrom, the offset value being used to increase a control tolerance (variant 1) and/or a control hysteresis (variant 3) and/or to reduce a power input or a climatic power output of the room air-conditioning device (variant 2), - wherein a standard control mode is additionally provided, in which a target value of the temperature serves as the reference variable without using the offset value, and - wherein a condition for the operation of the system is provided for switching between standard control mode and offset control mode.