A cold plasma delivery system, comprising: a cold plasma hand piece device, a high voltage power supply, and a gas cartridge; the gas cartridge having an outlet with a connector for connecting to said cold plasma hand piece device, said connector for having a seal across the outlet configured to be broken upon connection with the cold plasma hand piece device, the gas cartridge having a storage compartment configured to store a quantity of gas sufficient for a specific medical process; the cold plasma hand piece device having a mating connector, and further comprising: a nozzle (20; 68); a housing having a high voltage electrical inlet port and a gas compartment, the gas compartment having a gas inlet port and a gas outlet port connected to the nozzle; an electrode disposed within the gas compartment, wherein the electrode is coupled to the high voltage electrical inlet port; wherein the high voltage power supply is coupled to the high voltage electrical inlet port, wherein the cold plasma hand piece device is configured to connect with the connector of the gas cartridge through the mating connector, said mating connector having a pin for breaking said seal; and characterised in that the cartridge has a coding, wherein the connection between the cold plasma hand piece device with the gas cartridge triggers the high voltage power supply to apply a predetermined voltage, frequency and other related parameters thereof in response to the sensed coding of gas cartridge by said high voltage power supply. a cold plasma hand piece device, a high voltage power supply, and a gas cartridge; the gas cartridge having an outlet with a connector for connecting to said cold plasma hand piece device, said connector for having a seal across the outlet configured to be broken upon connection with the cold plasma hand piece device, the gas cartridge having a storage compartment configured to store a quantity of gas sufficient for a specific medical process; the cold plasma hand piece device having a mating connector, and further comprising: a nozzle (20; 68); a housing having a high voltage electrical inlet port and a gas compartment, the gas compartment having a gas inlet port and a gas outlet port connected to the nozzle; an electrode disposed within the gas compartment, wherein the electrode is coupled to the high voltage electrical inlet port; wherein the high voltage power supply is coupled to the high voltage electrical inlet port, wherein the cold plasma hand piece device is configured to connect with the connector of the gas cartridge through the mating connector, said mating connector having a pin for breaking said seal; and characterised in that the cartridge has a coding, wherein the connection between the cold plasma hand piece device with the gas cartridge triggers the high voltage power supply to apply a predetermined voltage, frequency and other related parameters thereof in response to the sensed coding of gas cartridge by said high voltage power supply. a nozzle (20; 68); a housing having a high voltage electrical inlet port and a gas compartment, the gas compartment having a gas inlet port and a gas outlet port connected to the nozzle; an electrode disposed within the gas compartment, wherein the electrode is coupled to the high voltage electrical inlet port; wherein the high voltage power supply is coupled to the high voltage electrical inlet port, wherein the cold plasma hand piece device is configured to connect with the connector of the gas cartridge through the mating connector, said mating connector having a pin for breaking said seal; and characterised in that the cartridge has a coding, wherein the connection between the cold plasma hand piece device with the gas cartridge triggers the high voltage power supply to apply a predetermined voltage, frequency and other related parameters thereof in response to the sensed coding of gas cartridge by said high voltage power supply.