A low waste syringe, comprising: a hollow body having an inner diameter, an inner wall and an end wall that closes the body at a forward end of the body, wherein the hollow body has an open rear end; a piston means having a piston cap for reciprocal sealing engagement with the inner wall of the body to define a chamber in the hollow body that is configured for selectively containing a fluid; a syringe tip mounted and extending longitudinally therefrom the end wall so that the syringe tip extends longitudinally away from the hollow body of the syringe, wherein an interior void is defined in the syringe tip and an aperture is defined in the end wall to place the interior void of the syringe tip in sealed fluid communication with the chamber of the hollow body, and a needle assembly, characterized in that two flanges extend radially away from a second end of the syringe tip, and characterized in that the interior void defines a substantially frusto-conical void, and characterized in that the needle assembly comprises an elongate needle and a needle hub, wherein the needle hub comprises a substantially cylindrical hollow needle base having internal threads defined thereon and a frusto-conical member formed in the needle base of the needle hub that extends longitudinally outwardly beyond the needle base to a proximal end and is configured to be selectively matingly received therein the frusto-conical void defined in the syringe tip, wherein the needle base of the needle hub defines a central bore that extends through an end wall of the needle base and the frusto-conical member, wherein the needle is positioned in the central bore such that a proximal end of the needle is mounted substantially aligned with the proximal end of the frusto-conical member, wherein at least a portion of the syringe tip can be substantially frusto-conical in shape, wherein a first end of the syringe tip has a first diameter configured to be coupled to the end wall of the body and a second end of the syringe tip is positioned a predetermined distance from the end wall and has a second diameter that is greater than the first diameter, wherein the interior void defined in the syringe tip defines a substantially frusto-conical shaped void, and wherein, upon the frictional engagement of the internal threads of the needle hub to the plurality of flanges of the syringe tip, the frusto-conical member of the needle base is configured to substantially fill the interior void of the syringe tip and the aperture of the hollow body to form a fluid tight seal and to minimize any dead space in the interior void of the syringe tip. a hollow body having an inner diameter, an inner wall and an end wall that closes the body at a forward end of the body, wherein the hollow body has an open rear end; a piston means having a piston cap for reciprocal sealing engagement with the inner wall of the body to define a chamber in the hollow body that is configured for selectively containing a fluid; a syringe tip mounted and extending longitudinally therefrom the end wall so that the syringe tip extends longitudinally away from the hollow body of the syringe, wherein an interior void is defined in the syringe tip and an aperture is defined in the end wall to place the interior void of the syringe tip in sealed fluid communication with the chamber of the hollow body, and a needle assembly, characterized in that two flanges extend radially away from a second end of the syringe tip, and characterized in that the interior void defines a substantially frusto-conical void, and characterized in that the needle assembly comprises an elongate needle and a needle hub, wherein the needle hub comprises a substantially cylindrical hollow needle base having internal threads defined thereon and a frusto-conical member formed in the needle base of the needle hub that extends longitudinally outwardly beyond the needle base to a proximal end and is configured to be selectively matingly received therein the frusto-conical void defined in the syringe tip, wherein the needle base of the needle hub defines a central bore that extends through an end wall of the needle base and the frusto-conical member, wherein the needle is positioned in the central bore such that a proximal end of the needle is mounted substantially aligned with the proximal end of the frusto-conical member, wherein at least a portion of the syringe tip can be substantially frusto-conical in shape, wherein a first end of the syringe tip has a first diameter configured to be coupled to the end wall of the body and a second end of the syringe tip is positioned a predetermined distance from the end wall and has a second diameter that is greater than the first diameter, wherein the interior void defined in the syringe tip defines a substantially frusto-conical shaped void, and wherein, upon the frictional engagement of the internal threads of the needle hub to the plurality of flanges of the syringe tip, the frusto-conical member of the needle base is configured to substantially fill the interior void of the syringe tip and the aperture of the hollow body to form a fluid tight seal and to minimize any dead space in the interior void of the syringe tip.