A method of identifying a potentially surgically operable target zone in an epileptic patient's brain comprising the following steps: providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone, the model of the epileptogenic zone being a mathematical model describing the onset, the time-course and the offset of the epileptic discharge, and loading said models in the computerized platform to obtain a computerized platform modelling an epileptic primate brain; identifying an estimated epileptogenic zone in the patient's brain; personalizing the computerized platform modelling the epileptic primate brain according to the patient's brain structural connectivity and parametrizing the estimated epileptogenic zone, in said computerized platform, as an epileptogenic zone, to obtain a patient's personalized computerized platform; carrying out a modularity analysis with the patient's brain structural connectivity to derive potential target zones acting as hubs in the interaction between modules, said potential target zones being outside the potential epileptogenic zone and such as, if they are surgically operated or removed, are minimizing epileptic seizure propagation, and evaluating the potential target zones' effectiveness to minimize propagation of epileptic seizures by network simulation simulating propagation characteristics of said epileptic seizures in the personalized patient's computerized platform and identifying one or more effective target zones, said effective target zones being outside the epileptogenic zone and such as, if they are surgically operated, are minimizing seizure propagation; evaluating the potential target zones' safety to maintain normal brain functions by network simulation wherein simulated spatiotemporal brain activation patterns in a defined state condition are obtained from the personalized computerized platform before and after removal of said zone and these simulated spatiotemporal brain activation patterns obtained before removal of the zone are compared with the simulated spatiotemporal brain activation patterns obtained after removal of the zone and, if the spatiotemporal brain activation patterns obtained before removal of the zone are substantially the same as the spatiotemporal brain activation patterns obtained after removal of the zone, then identifying said potential target zone as a safe target zone; and identifying the potential target zones which satisfy both effectiveness and safety evaluation criteria as potentially surgically operable target zones. providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone, the model of the epileptogenic zone being a mathematical model describing the onset, the time-course and the offset of the epileptic discharge, and loading said models in the computerized platform to obtain a computerized platform modelling an epileptic primate brain; identifying an estimated epileptogenic zone in the patient's brain; personalizing the computerized platform modelling the epileptic primate brain according to the patient's brain structural connectivity and parametrizing the estimated epileptogenic zone, in said computerized platform, as an epileptogenic zone, to obtain a patient's personalized computerized platform; carrying out a modularity analysis with the patient's brain structural connectivity to derive potential target zones acting as hubs in the interaction between modules, said potential target zones being outside the potential epileptogenic zone and such as, if they are surgically operated or removed, are minimizing epileptic seizure propagation, and evaluating the potential target zones' effectiveness to minimize propagation of epileptic seizures by network simulation simulating propagation characteristics of said epileptic seizures in the personalized patient's computerized platform and identifying one or more effective target zones, said effective target zones being outside the epileptogenic zone and such as, if they are surgically operated, are minimizing seizure propagation; evaluating the potential target zones' safety to maintain normal brain functions by network simulation wherein simulated spatiotemporal brain activation patterns in a defined state condition are obtained from the personalized computerized platform before and after removal of said zone and these simulated spatiotemporal brain activation patterns obtained before removal of the zone are compared with the simulated spatiotemporal brain activation patterns obtained after removal of the zone and, if the spatiotemporal brain activation patterns obtained before removal of the zone are substantially the same as the spatiotemporal brain activation patterns obtained after removal of the zone, then identifying said potential target zone as a safe target zone; and identifying the potential target zones which satisfy both effectiveness and safety evaluation criteria as potentially surgically operable target zones.