A nucleoside phosphoramidate compound of the following general formula I, or a stereoisomer, salt, hydrate, solvate or crystal thereof, wherein R 1 is selected from C 1-6 alkyl; R 2 is selected from halogen; R 3 is selected from OH, H and C 1-4 alkoxy; R 4 is selected from H, C 1-6 alkyl and halogenated C 1-6 alkyl; R 5 is selected from C 1-6 alkyl and halogenated C 1-6 alkyl; R 6 is selected from the following moieties: a) phenyl-Y-, wherein Y is absent or selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 alkenyl- -, C 2-6 alkynyl- -, O, S, amino and -N(C 1-6 alkyl), and wherein the phenyl is optionally substituted by one or more groups selected from C 1-6 alkyl, halogen, nitro, C 1-6 alkoxy, cyano, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 acylamino, halogenated C 1-6 alkyl, halogenated C 1-6 alkoxy, amino, N(C 1-6 alkyl) 2 and C 1-6 alkyl NHCO, or the phenyl and a five- or six-membered ring taken together form a benzo five-membered ring or benzo six-membered ring; and R 7 is selected from H, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, NO 2, CN, C 1-6 alkyl-NH-CO-, hydroxy, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, C 1-6 alkyl-S-, C 2-6 alkenyl-S-, C 2-6 alkynyl-S-, C 1-6 alkyl-SO-, C 2-6 alkenyl-SO-, C 2-6 alkynyl-SO-, C 1-6 alkyl-SO 2 -, C 2-6 alkenyl-SO 2 -, C 2-6 alkynyl-SO 2 -, C 1-6 alkyl-OSO 2 -, C 2-6 alkenyl-OSO 2 -, C 2-6 alkenyl-OSO 2 -. R 1 is selected from C 1-6 alkyl; R 2 is selected from halogen; R 3 is selected from OH, H and C 1-4 alkoxy; R 4 is selected from H, C 1-6 alkyl and halogenated C 1-6 alkyl; R 5 is selected from C 1-6 alkyl and halogenated C 1-6 alkyl; R 6 is selected from the following moieties: a) phenyl-Y-, wherein Y is absent or selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 alkenyl- -, C 2-6 alkynyl- -, O, S, amino and -N(C 1-6 alkyl), and wherein the phenyl is optionally substituted by one or more groups selected from C 1-6 alkyl, halogen, nitro, C 1-6 alkoxy, cyano, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 acylamino, halogenated C 1-6 alkyl, halogenated C 1-6 alkoxy, amino, N(C 1-6 alkyl) 2 and C 1-6 alkyl NHCO, or the phenyl and a five- or six-membered ring taken together form a benzo five-membered ring or benzo six-membered ring; and a) phenyl-Y-, wherein Y is absent or selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2-6 alkenyl- -, C 2-6 alkynyl- -, O, S, amino and -N(C 1-6 alkyl), and wherein the phenyl is optionally substituted by one or more groups selected from C 1-6 alkyl, halogen, nitro, C 1-6 alkoxy, cyano, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 acylamino, halogenated C 1-6 alkyl, halogenated C 1-6 alkoxy, amino, N(C 1-6 alkyl) 2 and C 1-6 alkyl NHCO, or the phenyl and a five- or six-membered ring taken together form a benzo five-membered ring or benzo six-membered ring; and R 7 is selected from H, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, NO 2, CN, C 1-6 alkyl-NH-CO-, hydroxy, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, C 1-6 alkyl-S-, C 2-6 alkenyl-S-, C 2-6 alkynyl-S-, C 1-6 alkyl-SO-, C 2-6 alkenyl-SO-, C 2-6 alkynyl-SO-, C 1-6 alkyl-SO 2 -, C 2-6 alkenyl-SO 2 -, C 2-6 alkynyl-SO 2 -, C 1-6 alkyl-OSO 2 -, C 2-6 alkenyl-OSO 2 -, C 2-6 alkenyl-OSO 2 -.