mhurhangee/ep-ind-claims huggingface dataset:
A compound having the formula: or a stereoisomer, or pharmaceutically acceptable salt, wherein each R 1, R 2, R 3, and R 4 is, independently, N or CR 5, wherein each R 5 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo-C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo-C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, C 1-7 acyl, C 1-7 acylamino, C 1-7 acyloxy, C 6-10 aryl, C 1-6 alk-C 6-10 aryl, amino, halo, cyano, nitro, hydroxy, or carboxyl; A is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-7 acyl, C 1-12 heterocyclyl, carboxyl, -C -NR A1 R A2, or -NR A1 -C -R A2, wherein each R A1 and R A2 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 alkoxy-C 1-6 alkyl, or wherein the combination of R A1 and R A2 can together form C 1-12 heterocyclyl; X is and wherein each of X a, X b, and X c is, independently, selected from O, S, NR X1, N, or CR X2; R X1 is H or C 1-6 alkyl; and R X2 is H, halo, or C 1-6 alkyl; L is -CH 2 -NZ N1 - or -CH 2 -O-, wherein each Z N1 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or an N -protecting group; each Z 3a, Z 3b, Z 4, Z 5a and Z 5b is, independently, H, or C 1-6 alkyl; and Y is bicyclic C 1-12 heterocyclyl. each R 1, R 2, R 3, and R 4 is, independently, N or CR 5, wherein each R 5 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo-C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo-C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, C 1-7 acyl, C 1-7 acylamino, C 1-7 acyloxy, C 6-10 aryl, C 1-6 alk-C 6-10 aryl, amino, halo, cyano, nitro, hydroxy, or carboxyl; A is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-7 acyl, C 1-12 heterocyclyl, carboxyl, -C -NR A1 R A2, or -NR A1 -C -R A2, wherein each R A1 and R A2 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 alkoxy-C 1-6 alkyl, or wherein the combination of R A1 and R A2 can together form C 1-12 heterocyclyl; X is and wherein each of X a, X b, and X c is, independently, selected from O, S, NR X1, N, or CR X2; R X1 is H or C 1-6 alkyl; and R X2 is H, halo, or C 1-6 alkyl; L is -CH 2 -NZ N1 - or -CH 2 -O-, wherein each Z N1 is, independently, H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or an N -protecting group; each Z 3a, Z 3b, Z 4, Z 5a and Z 5b is, independently, H, or C 1-6 alkyl; and Y is bicyclic C 1-12 heterocyclyl. each Z 3a, Z 3b, Z 4, Z 5a and Z 5b is, independently, H, or C 1-6 alkyl; and Y is bicyclic C 1-12 heterocyclyl.
A method for polishing a semiconductor wafer on both sides, polishing pads of a Shore A hardness at room temperature of at least 80 and having a compressibility at room temperature of less than 3% being attached to upper and lower polishing plates, a semiconductor wafer being polished on both sides between upper and lower polishing pads, wherein the polishing pads are attached to the upper and lower polishing plate by bonding the polishing pads to the upper and lower polishing plate, by positioning a pad having a compressibility at room temperature of at least 3% between the two bonded polishing pads as intermediate layer and by then pressing together the two polishing pads with the pad situated therebetween for a certain period of time.
A method of three-dimensionally detecting a fiber material surface of a fiber material of a fiber composite material deposited on a tool by means of a detection device, the method comprising the steps of: - detecting radiation reflected from at least a portion of the fiber material surface by means of a first polarization-sensitive detection sensor from a first detection direction and generating first polarization-dependent measurement data as a function of the detected reflected radiation, - detecting the radiation reflected from at least said portion of the fiber material surface by means of at least a second polarization-sensitive detection sensor from a second detection direction different from the first detection direction and generating at least second polarization-dependent measurement data as a function of the detected reflected radiation, and - creating three-dimensional surface data of the fiber material surface as a three-dimensional digital image of the real fiber material surface as a function of the first polarization-dependent measurement data and the at least second polarization-dependent measurement data by means of a data processing unit. - detecting radiation reflected from at least a portion of the fiber material surface by means of a first polarization-sensitive detection sensor from a first detection direction and generating first polarization-dependent measurement data as a function of the detected reflected radiation, - detecting the radiation reflected from at least said portion of the fiber material surface by means of at least a second polarization-sensitive detection sensor from a second detection direction different from the first detection direction and generating at least second polarization-dependent measurement data as a function of the detected reflected radiation, and - creating three-dimensional surface data of the fiber material surface as a three-dimensional digital image of the real fiber material surface as a function of the first polarization-dependent measurement data and the at least second polarization-dependent measurement data by means of a data processing unit.
An isolated, fully human antibody of an IgG class that binds to a CD38 epitope, wherein said antibody has a heavy chain/light chain variable domain sequence of SEQ ID NO. 3/SEQ ID NO. 4.
A method of determining status of multiple sclerosis, the method comprises: (a) detecting a level of a biomarker selected from the group consisting of Tau, a fragment of Tau of SEQ ID NO:2 to SEQ ID NO: 80, phosphorylated Tau, and hippocalcin-1, in a first blood sample, wherein the first blood sample is a peripheral phagocyte sample comprising a first circulating phagocyte; (b) comparing the level of the biomarker in the first blood sample with a level of the biomarker in a second fluid sample, the second fluid sample being either a control sample or a second peripheral phagocyte sample, the second peripheral phagocyte sample comprising a second circulating phagocyte, the second fluid sample being collected prior to the first blood sample; wherein if the biomarker level in the first blood sample is the same as the level of the biomarker in the second fluid sample or in the control sample, then disease activity has not increased or decreased; wherein if the biomarker level in the first blood sample is higher than the level of the biomarker in the second fluid sample or in the control sample, then disease activity has increased; wherein if the biomarker level in the first blood sample is lower than the level of the biomarker in the second fluid sample or in the control sample, then disease activity has decreased. (a) detecting a level of a biomarker selected from the group consisting of Tau, a fragment of Tau of SEQ ID NO:2 to SEQ ID NO: 80, phosphorylated Tau, and hippocalcin-1, in a first blood sample, wherein the first blood sample is a peripheral phagocyte sample comprising a first circulating phagocyte; (b) comparing the level of the biomarker in the first blood sample with a level of the biomarker in a second fluid sample, the second fluid sample being either a control sample or a second peripheral phagocyte sample, the second peripheral phagocyte sample comprising a second circulating phagocyte, the second fluid sample being collected prior to the first blood sample;
A process for the preparation of Levothyroxine of formula comprising iodination of compound of formula with sodium iodide and sodium hypochlorite in the presence of an aliphatic amine.
A method for controlling a communication apparatus operating as an access point, the method comprises: transmitting via a Physical, PHY, layer, a trigger frame to trigger a multi-user, MU, transmission, wherein the trigger frame allocates one or more resource units of the MU transmission for data transmission towards one or more stations, and characterised by configuring the PHY layer in a receive state to receive one or more data frames over a frequency band excluding the one or more resource units allocated for the data transmission towards the one or more stations. transmitting via a Physical, PHY, layer, a trigger frame to trigger a multi-user, MU, transmission, wherein the trigger frame allocates one or more resource units of the MU transmission for data transmission towards one or more stations, and characterised by configuring the PHY layer in a receive state to receive one or more data frames over a frequency band excluding the one or more resource units allocated for the data transmission towards the one or more stations.
Screen covering comprising: - several cross-beams arranged so as to be slidable away from each other and towards each other; - a screen supported by the cross-beams and designed to fold between the cross-beams during sliding of the cross-beams; - a lateral gutter, which extends essentially perpendicular to the cross-beams and is arranged below a lateral side of the screen; characterised in that said lateral side of the screen is provided with a downwardly extending drip guard, which is designed to fold during sliding of the cross-beams. - several cross-beams arranged so as to be slidable away from each other and towards each other; - a screen supported by the cross-beams and designed to fold between the cross-beams during sliding of the cross-beams; - a lateral gutter, which extends essentially perpendicular to the cross-beams and is arranged below a lateral side of the screen;
Center plate for a rotor in a pulp refiner, said center plate having a surface provided with a plurality of first wings for directing pulp flowing onto the center of the center plate towards the periphery of said plate, where - each of said first wings are an arc-shaped protrusion extending between a corresponding first point and a corresponding second point on said surface, said first point (11 a) being displaced from the center point of the plate and said second point being arranged further from the center point than said first point, characterized in that said surface is a flat surface or a surface with a central protuberance, and said first wings, extending between corresponding first and second points (11a, 11b), are given an arc-shape that yields a larger pulp feeding angle than a circular arc intersecting the center point of the center plate and ending in the same corresponding second point and that said second point of each of said first wings lies on the periphery of the center plate. - each of said first wings are an arc-shaped protrusion extending between a corresponding first point and a corresponding second point on said surface, said first point (11 a) being displaced from the center point of the plate and said second point being arranged further from the center point than said first point, characterized in that said surface is a flat surface or a surface with a central protuberance, and said first wings, extending between corresponding first and second points (11a, 11b), are given an arc-shape that yields a larger pulp feeding angle than a circular arc intersecting the center point of the center plate and ending in the same corresponding second point and that said second point of each of said first wings lies on the periphery of the center plate.
A force-measurement system for a minimally invasive medical device, the force measurement system comprising: a central axis; and three or more pressure-sensor chambers (110, 410, 710, 810, 910, 1010, 1110, 1210, 1510, 1610) placed radially around the central axis, each pressure-sensor chamber comprising a fluid (1116, 1216) housed in the chamber and a pressure sensor (712, 812, 1012, 1112, 1212, 1312, 1512, 1612) located in each pressure-sensor chamber and positioned to sense a pressure on the fluid (1116, 1216) housed in each pressure-sensor chamber. a central axis; and three or more pressure-sensor chambers (110, 410, 710, 810, 910, 1010, 1110, 1210, 1510, 1610) placed radially around the central axis, each pressure-sensor chamber comprising a fluid (1116, 1216) housed in the chamber and a pressure sensor (712, 812, 1012, 1112, 1212, 1312, 1512, 1612) located in each pressure-sensor chamber and positioned to sense a pressure on the fluid (1116, 1216) housed in each pressure-sensor chamber.
Method for determining a sensor coil inductance of an eddy current sensor by means of an LC oscillator circuit which has the inductance of the eddy current sensor, an internal resistance (R C) of the eddy current sensor and a resonance capacitor (C R), wherein the sensor coil inductance is determined as a function of an oscillation frequency (f LC) and a resonance capacitance of the LC oscillator circuit, wherein the determination of the coil inductance is carried out by counting the periods within an integration period, characterized in that during the integration period, the oscillation frequency (f LC) is detuned at least once.
A skin engaging member for use on a hair removal device, said skin engaging member comprising: a. a carrier having a skin contacting surface, said skin contacting surface forming at least one orifice; and b. a lubricating material releasably engaged with said carrier; said at least one orifice exposing at least a portion of said lubricating material; wherein the lubricating material comprises a copolymer of polyethylene oxide and polypropylene oxide, wherein said copolymer of polyethylene oxide and polypropylene oxide has an average molecular weight of from 12,000 to 13,000. a. a carrier having a skin contacting surface, said skin contacting surface forming at least one orifice; and b. a lubricating material releasably engaged with said carrier; said at least one orifice exposing at least a portion of said lubricating material;
A power cable (300; 400; 500; 600) for an aircraft power distribution system, the power cable comprising: an elongated thermal conductor manufactured from pyrolytic graphite or carbon nanotubes; and an electrical conductor layer surrounding at least a portion of the elongated thermal conductor, the electrical conductor layer manufactured from a copper alloy, an aluminum alloy or a combination of copper, iron and silver alloys; wherein heat generated in the power cable (300; 400; 500; 600) is transferred via the elongated thermal conductor to at least one end of the power cable (300; 400; 500; 600); wherein the power cable further comprises a second thermal conductor layer surrounding at least a portion of the electrical conductor layer; wherein the power cable further comprises an electric insulation layer surrounding at least a portion of the second thermal conductor layer; and wherein the power cable further comprises a thermal insulation layer surrounding at least a portion of the electric insulation layer. an elongated thermal conductor manufactured from pyrolytic graphite or carbon nanotubes; and an electrical conductor layer surrounding at least a portion of the elongated thermal conductor, the electrical conductor layer manufactured from a copper alloy, an aluminum alloy or a combination of copper, iron and silver alloys; wherein heat generated in the power cable (300; 400; 500; 600) is transferred via the elongated thermal conductor to at least one end of the power cable (300; 400; 500; 600); wherein the power cable further comprises a second thermal conductor layer surrounding at least a portion of the electrical conductor layer; wherein the power cable further comprises an electric insulation layer surrounding at least a portion of the second thermal conductor layer; and wherein the power cable further comprises a thermal insulation layer surrounding at least a portion of the electric insulation layer.
An acetabular cup and sheath assembly, comprising: a. a sheath; and b. an acetabular cup; wherein the sheath is configured to receive the acetabular cup within the sheath, the sheath and acetabular cup together configured to pass through a surgical wound toward an implantation site; and wherein the sheath further comprises a penetration structure for passing the acetabular cup through the sheath when the acetabular cup is proximately close to an implantation site, characterised in that the sheath is cup-shaped and the penetration structure is sized such that the cup is retained within the sheath as the sheath and the cup are passed through a surgical wound. a. a sheath; and b. an acetabular cup; wherein the sheath is configured to receive the acetabular cup within the sheath, the sheath and acetabular cup together configured to pass through a surgical wound toward an implantation site; and wherein the sheath further comprises a penetration structure for passing the acetabular cup through the sheath when the acetabular cup is proximately close to an implantation site, characterised in that the sheath is cup-shaped and the penetration structure is sized such that the cup is retained within the sheath as the sheath and the cup are passed through a surgical wound.
A method for winding up a web of mineral wool nonwovens into a wound roll by means of an apparatus comprising stationary and mobile devices including at least: - one winding-up space for accommodating an at least partially wound roll having a winding center; - means for conveying and/or manipulating the web of mineral wool nonwovens prior to and/or during winding-up; characterized by including the following steps: a) operating the apparatus; b) monitoring the web of mineral wool nonwovens and/or the resulting wound roll by means of at least one image-capturing device for obtaining at least one actual state of the web of mineral wool nonwovens and/or of the wound roll; c) comparing the at least one actual state to at least one target state and corresponding to the actual state, and determining at least one deviation of the actual state from the corresponding target state; d) if the deviation exceeds/falls below at least one predetermined limit value, performing a correction of at least one operating parameter of the apparatus, the operating parameter being at least a contribution factor for the deviation. - one winding-up space for accommodating an at least partially wound roll having a winding center; - means for conveying and/or manipulating the web of mineral wool nonwovens prior to and/or during winding-up; a) operating the apparatus; b) monitoring the web of mineral wool nonwovens and/or the resulting wound roll by means of at least one image-capturing device for obtaining at least one actual state of the web of mineral wool nonwovens and/or of the wound roll; c) comparing the at least one actual state to at least one target state and corresponding to the actual state, and determining at least one deviation of the actual state from the corresponding target state; d) if the deviation exceeds/falls below at least one predetermined limit value, performing a correction of at least one operating parameter of the apparatus, the operating parameter being at least a contribution factor for the deviation.
A method for preparing heat-killed Lactobacillus rhamnosus conjugated to a polymeric polysaccharide binder, the method comprising: (a) separating a fermentation culture medium prepared by culturing Lactobacillus rhamnosus into bacteria and a fermentation filtrate; (b) mixing the fermentation filtrate of step (a) and a polymeric polysaccharide to prepare a polymeric polysaccharide binder; (c) heat-killing the bacteria separated in step (a); and (d) conjugating the heat-killed bacteria of step (c) to the binder prepared in step (b). (a) separating a fermentation culture medium prepared by culturing Lactobacillus rhamnosus into bacteria and a fermentation filtrate; (b) mixing the fermentation filtrate of step (a) and a polymeric polysaccharide to prepare a polymeric polysaccharide binder; (c) heat-killing the bacteria separated in step (a); and (d) conjugating the heat-killed bacteria of step (c) to the binder prepared in step (b).
A method of detecting the state of a cutting device for agricultural crop material, wherein the cutting device includes a cutting tool which can be caused to rotate with respect to a counterpart cutting member and wherein the spacing position of the counterpart cutting member with respect to the cutting tool is variable, characterised in that associated with the counterpart cutting member are at least two mutually spaced sensors (11, 12) for detecting vibrations which the cutting tool causes upon contact with the counterpart cutting member, wherein signals produced by the sensors (11, 12) are transmitted to a common signal analysis device which by comparison of the signals ascertains a state of the cutting device.
An assembly comprising: a reservoir for holding a fluid; a supply passage connected to the reservoir for supplying the fluid to the delivery location; a scavenge passage connected to the reservoir at a reservoir inlet for returning the fluid from a delivery location to the reservoir; and a bleed passage connected in fluid communication between the reservoir and the scavenge passage; characterised in that the assembly further comprises: a bleed passage valve operably connected to the bleed passage, wherein the bleed passage valve limits or reduces fluid flow from the scavenge passage to the reservoir through the bleed passage; and wherein the bleed passage is connected to the scavenge passage upstream from the reservoir inlet and is configured to allow fluid transfer from the reservoir to the scavenge passage. a reservoir for holding a fluid; a supply passage connected to the reservoir for supplying the fluid to the delivery location; a scavenge passage connected to the reservoir at a reservoir inlet for returning the fluid from a delivery location to the reservoir; and a bleed passage connected in fluid communication between the reservoir and the scavenge passage; characterised in that the assembly further comprises: a bleed passage valve operably connected to the bleed passage, wherein the bleed passage valve limits or reduces fluid flow from the scavenge passage to the reservoir through the bleed passage; and wherein the bleed passage is connected to the scavenge passage upstream from the reservoir inlet and is configured to allow fluid transfer from the reservoir to the scavenge passage. a bleed passage valve operably connected to the bleed passage, wherein the bleed passage valve limits or reduces fluid flow from the scavenge passage to the reservoir through the bleed passage; and wherein the bleed passage is connected to the scavenge passage upstream from the reservoir inlet and is configured to allow fluid transfer from the reservoir to the scavenge passage.
Method for regulating the gas/air admixture by means of a mixing device in fully pre-mixing gas burners with a fan which is arranged upstream of the burner, wherein the mixing device contains a measuring device which is suitable for detecting the pressure difference between the air and gas supply (5, 6), wherein the mixing device has an adjustable gas valve and wherein the mixing device has a regulator which is connected to the measuring device and to the gas valve and the fan, wherein the steps are carried out cyclically: - measuring the pressure difference with a high sampling rate, - establishing the scattering of the measurement values, - low-pass filtering of the measurement values, - regulating the gas valve in such a manner that the pressure difference which is represented by the low-pass-filtered measurement values are adjusted to zero, - comparing the scattering with a stored reference value, - intervention in the regulating variables of the gas valve and/or the fan when the reference value is exceeded by a threshold value. - measuring the pressure difference with a high sampling rate, - establishing the scattering of the measurement values, - low-pass filtering of the measurement values, - regulating the gas valve in such a manner that the pressure difference which is represented by the low-pass-filtered measurement values are adjusted to zero, - comparing the scattering with a stored reference value, - intervention in the regulating variables of the gas valve and/or the fan when the reference value is exceeded by a threshold value.