The compound of formula Ia or IIa: wherein: R 4 is chloro R 3 is: halo; C 1-6 alkyl; halo-C 1-6 alkyl;C 1-6 alkenyl; C 1-6 alkoxy; halo-C 1-6 alkoxy; hydroxy-C 1-6 alkyl; hydroxy-C 1-6 alkylamino; C 1-6 alkyl-amino; hydroxy; amino; amino-C 1-6 alkyl; aminocarbonyl; hydroxy-C 1-6 alkoxy; hydroxy-C 1-6 alkenyl; C 1-6 alkoxy- C 1-6 alkoxy;C 1-6 alkylsulfonyl;C 1-6 alkylsulfanyl; piperidinyl wherein the piperidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; phenylaminocarbonyl; hydroxy-C 1-6 alkylamino; cyclohexyloxy wherein the cyclohexyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl or hydroxy-C 1-6 alkyl; cyclopentyloxy wherein the cyclopentyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl or hydroxy-C 1-6 alkyl; piperidinyloxy wherein the piperidinyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; phenyl wherein the phenyl moiety is optionally substituted with amino, hydroxy, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; pyrrolidinyl wherein the pyrrolidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; pyrrolidinyloxy wherein the pyrrolidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; piperazinyl wherein the piperazinyl moiety is optionally substituted with C 1-6 alkyl; oxazol-C 1-6 alkoxy wherein the oxazol moiety thereof is optionally substituted with C 1-6 alkyl; morpholinyl; hydroxy-C 1-6 alkylaminocarbonyl; C 3-6 cycloalkyl; azepanyl wherein the azepanyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; benzyl wherein the phenyl moiety thereof is optionally substituted with amino, hydroxy, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; C 1-6 alkoxycarbonyl-C 1-6 alkoxy; or C 1-6 alkylcarbonylamino; and R 1 is:hydrogen; C 1-6 alkyl; C 1-6 alkoxy; hydroxy; hydroxy-C 1-6 alkyl; C 1-6 alkyl-amino; amino-C 1-6 alkyl; amino-C 1-6 alkyl-amino; hydroxy- C 1-6 alkylamino, C 3-6 cycloalkylamino; aminocarbonyl; halo; hydroxy-C 1-6 alkyl; or hydroxy-C 1-6 alkoxy. R 4 is chloro R 3 is: halo; C 1-6 alkyl; halo-C 1-6 alkyl;C 1-6 alkenyl; C 1-6 alkoxy; halo-C 1-6 alkoxy; hydroxy-C 1-6 alkyl; hydroxy-C 1-6 alkylamino; C 1-6 alkyl-amino; hydroxy; amino; amino-C 1-6 alkyl; aminocarbonyl; hydroxy-C 1-6 alkoxy; hydroxy-C 1-6 alkenyl; C 1-6 alkoxy- C 1-6 alkoxy;C 1-6 alkylsulfonyl;C 1-6 alkylsulfanyl; piperidinyl wherein the piperidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; phenylaminocarbonyl; hydroxy-C 1-6 alkylamino; cyclohexyloxy wherein the cyclohexyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl or hydroxy-C 1-6 alkyl; cyclopentyloxy wherein the cyclopentyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl or hydroxy-C 1-6 alkyl; piperidinyloxy wherein the piperidinyl moiety thereof is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; phenyl wherein the phenyl moiety is optionally substituted with amino, hydroxy, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; pyrrolidinyl wherein the pyrrolidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; pyrrolidinyloxy wherein the pyrrolidinyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; piperazinyl wherein the piperazinyl moiety is optionally substituted with C 1-6 alkyl; oxazol-C 1-6 alkoxy wherein the oxazol moiety thereof is optionally substituted with C 1-6 alkyl; morpholinyl; hydroxy-C 1-6 alkylaminocarbonyl; C 3-6 cycloalkyl; azepanyl wherein the azepanyl moiety is optionally substituted with hydroxy, amino, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; benzyl wherein the phenyl moiety thereof is optionally substituted with amino, hydroxy, amino-C 1-6 alkyl, hydroxy-C 1-6 alkyl or aminocarbonyl; C 1-6 alkoxycarbonyl-C 1-6 alkoxy; or C 1-6 alkylcarbonylamino; and R 1 is:hydrogen; C 1-6 alkyl; C 1-6 alkoxy; hydroxy; hydroxy-C 1-6 alkyl; C 1-6 alkyl-amino; amino-C 1-6 alkyl; amino-C 1-6 alkyl-amino; hydroxy- C 1-6 alkylamino, C 3-6 cycloalkylamino; aminocarbonyl; halo; hydroxy-C 1-6 alkyl; or hydroxy-C 1-6 alkoxy.