Nucleic acid sequence comprising or coding for a) a coding region, encoding at least one peptide or protein; b) at least one histone stem-loop derived from histone genes, comprising an intramolecular base pairing of two neighbored entirely or partially reverse complementary sequences; and c) a poly sequence or a polyadenylation signal; wherein said protein or peptide antigen is an autoimmune self-antigen or a fragment, variant or derivative of said autoimmune self-antigen, having the specific antigenic property of the full-length native peptide or protein, asscociated with an autoimmune disease selected from alopecia areata, Addison's anemia (Morbus Biermer), autoimmune hemolytic anemia (AIHA) of the cold type (cold hemagglutinine disease, cold autoimmune hemolytic anemia (AIHA) (including cold agglutinin disease), autoimmune hemolytic anemia (AIHA) of the warm type (warm AIHA, warm autoimmune haemolytic anemia (AIHA)), autoimmune hemolytic Donath-Landsteiner anemia (paroxysmal cold hemoglobinuria), antiphospholipid syndrome, atherosclerosis, autoimmune arthritis, arteriitis temporalis, Takayasu arteriitis (Takayasu's disease, aortic arch disease), temporal arteriitis/giant cell arteriitis, autoimmune chronic gastritis, autoimmune infertility, autoimmune inner ear disease (AIED), Behcet's syndrome (Morbus Behcet), cardiomyopathy, particularly autoimmune cardiomyopathy, idiopathic dilated cardiomyopathy, celiac sprue dermatitis (gluten mediated enteropathia), chronic fatigue immune dysfunction syndrome (CFIDS), chronic inflammatory demyelinating polyneuropathy (CIDP), chronic polyarthritis, Churg-Strauss syndrome, cicatricial pemphigoid, Cogan syndrome, CREST syndrome (syndrom with Calcinosis cutis), Raynaud phenomenon, motility disorders of the esophagus, sklerodaktylia and teleangiectasia, dermatitis herpetiformis Duhring, dermatomyositis, essential mixed cryoglobulinemia, fibromyositis, Goodpasture syndrome (anti-GBM mediated glomerulonephritis), graft versus host disease, Guillain-Barré syndrome (GBM, Polyradikuloneuritis), haematologic autoimmune diseases, hemophilia, acquired hemophilia, idiopathic pulmonary fibrosis, idiopathic thrombocytopenic purpura, Immuno-thrombocytopenic purpura (Morbus Werlhof; ITP), IgA nephropathy, infertility, autoimmune infertility, juvenile rheumatoid arthritis (Morbus Still, Still syndrome), Lambert-Eaton syndrome, lichen planus, lichen sclerosus, lupus erythematosus (discoid form), Lyme arthritis (Lyme disease, borrelia arthritis), Ménierè's disease (Morbus Ménierè); mixed connective tissue disease (MCTD), encephalomyelitis disseminate, Charcot's disease, myositis, bullous pemphigoid, scar forming pemphigoid; polyarteriitis nodosa (periarteriitis nodosa), polychondritis (panchondritis), polyglandular (autoimmune) syndrome (PGA syndrome, Schmidt's syndrome), primary agammaglobulinemia, primary biliary cirrhosis PBC, primary autoimmune cholangitis, Psoriasis vulgaris, Raynaud's phenomena, rheumatic fever, sarcoidosis (Morbus Boeck, Besnier-Boeck-Schaumann disease), stiff-man syndrome, sympathetic ophtalmia, Transient gluten intolerance, transplanted organ rejection, uveitis, autoimmune uveiitis, Vitiligo (leucoderma, piebald skin), and Wegner's disease (Morbus Wegner, Wegner's granulomatosis). a) a coding region, encoding at least one peptide or protein; b) at least one histone stem-loop derived from histone genes, comprising an intramolecular base pairing of two neighbored entirely or partially reverse complementary sequences; and c) a poly sequence or a polyadenylation signal;